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{"X":26,"KEGG":"R00039","RHEA_ID":14128,"DIRECTION":"BI","MASTER_ID":14125,"compounds":"2 raffinose <=> 1(F)-alpha-D-galactosylraffinose + sucrose","pmd":162.053}
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{"X":73,"KEGG":"R00105","RHEA_ID":12263,"DIRECTION":"BI","MASTER_ID":12260,"compounds":"ATP + NADH <=> ADP + H(+) + NADPH","pmd":79.966}
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{"X":100,"KEGG":"R00132","RHEA_ID":10751,"DIRECTION":"BI","MASTER_ID":10748,"ecocyc":"RXN0-5224","metacyc":"CARBODEHYDRAT-RXN","compounds":"H(+) + hydrogencarbonate <=> CO2 + H2O"}
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{"X":106,"KEGG":"R00141","RHEA_ID":11027,"DIRECTION":"BI","MASTER_ID":11024,"compounds":"ATP + NH4(+) <=> ADP + 2 H(+) + phosphoramidate","pmd":79.966}
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{"X":108,"KEGG":"R00149","RHEA_ID":10627,"DIRECTION":"BI","MASTER_ID":10624,"compounds":"2 ATP + CO2 + H2O + NH4(+) <=> 2 ADP + carbamoyl phosphate + 3 H(+) + phosphate","pmd":79.966}
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{"X":415,"KEGG":"R00497","RHEA_ID":13560,"DIRECTION":"BI","MASTER_ID":13557,"compounds":"ATP + glycine + L-gamma-glutamyl-L-cysteine <=> ADP + glutathione + H(+) + phosphate","pmd":57.022}
{"X":416,"KEGG":"R00499","RHEA_ID":16716,"DIRECTION":"BI","MASTER_ID":16713,"compounds":"H2O + S-succinylglutathione <=> glutathione + H(+) + succinate","pmd":100.016}
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{"X":418,"KEGG":"R00502","RHEA_ID":14212,"DIRECTION":"BI","MASTER_ID":14209,"metacyc":"UTPHEXPURIDYLYLTRANS-RXN","compounds":"alpha-D-galactose 1-phosphate + H(+) + UTP <=> diphosphate + UDP-alpha-D-galactose","pmd":82.086}
{"X":419,"KEGG":"R00503","RHEA_ID":12407,"DIRECTION":"BI","MASTER_ID":12404,"metacyc":"LACTOSE-SYNTHASE-RXN","compounds":"D-glucose + UDP-alpha-D-galactose <=> H(+) + lactose + UDP","pmd":162.053}
{"X":420,"KEGG":"R00504","RHEA_ID":22443,"DIRECTION":"BI","MASTER_ID":22440,"compounds":"UDP-alpha-D-galactose + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + UDP-N-acetyl-6-(alpha-D-galactose-1-phospho)-alpha-D-glucosamine + UMP","pmd":242.019}
{"X":421,"KEGG":"R00505","RHEA_ID":24135,"DIRECTION":"BI","MASTER_ID":24132,"ecocyc":"GALPMUT-RXN","metacyc":"GALPMUT-RXN","compounds":"UDP-alpha-D-galactose <=> UDP-alpha-D-galactofuranose","pmd":0}
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{"X":423,"KEGG":"R00509","RHEA_ID":24155,"DIRECTION":"BI","MASTER_ID":24152,"ecocyc":"ADENYLYLSULFKIN-RXN","metacyc":"ADENYLYLSULFKIN-RXN","compounds":"adenosine 5'-phosphosulfate + ATP <=> 3'-phosphoadenylyl sulfate + ADP + H(+)","pmd":0.01}
{"X":424,"KEGG":"R00510","RHEA_ID":30078,"DIRECTION":"BI","MASTER_ID":30075,"compounds":"CMP + H2O <=> cytosine + D-ribose 5-phosphate","pmd":93.033}
{"X":425,"KEGG":"R00511","RHEA_ID":29370,"DIRECTION":"BI","MASTER_ID":29367,"compounds":"CMP + H2O <=> cytidine + phosphate","pmd":79.966}
{"X":426,"KEGG":"R00512","RHEA_ID":11603,"DIRECTION":"BI","MASTER_ID":11600,"compounds":"ATP + CMP <=> ADP + CDP","pmd":79.966}
{"X":427,"KEGG":"R00513","RHEA_ID":24677,"DIRECTION":"BI","MASTER_ID":24674,"compounds":"ATP + cytidine <=> ADP + CMP + H(+)","pmd":79.966}
{"X":428,"KEGG":"R00515","RHEA_ID":27765,"DIRECTION":"BI","MASTER_ID":27762,"compounds":"CTP + H2O <=> CMP + diphosphate + H(+)","pmd":159.933}
{"X":429,"KEGG":"R00517","RHEA_ID":28165,"DIRECTION":"BI","MASTER_ID":28162,"ecocyc":"CYTIDINEKIN-RXN","metacyc":"CYTIDINEKIN-RXN","compounds":"cytidine + GTP <=> CMP + GDP + H(+)","pmd":79.966}
{"X":430,"KEGG":"R00518","RHEA_ID":16012,"DIRECTION":"BI","MASTER_ID":16009,"compounds":"ATP + formate <=> ADP + formyl phosphate","pmd":79.966}
{"X":431,"KEGG":"R00519","RHEA_ID":15988,"DIRECTION":"BI","MASTER_ID":15985,"metacyc":"1.2.1.2-RXN","compounds":"formate + NAD(+) <=> CO2 + NADH"}
{"X":432,"KEGG":"R00521","RHEA_ID":19744,"DIRECTION":"BI","MASTER_ID":19741,"compounds":"formyl-CoA + H2O <=> CoA + formate + H(+)","pmd":27.995}
{"X":433,"KEGG":"R00522","RHEA_ID":16512,"DIRECTION":"BI","MASTER_ID":16509,"metacyc":"OXALATE-DECARBOXYLASE-RXN","compounds":"H(+) + oxalate <=> CO2 + formate"}
{"X":434,"KEGG":"R00524","RHEA_ID":21951,"DIRECTION":"BI","MASTER_ID":21948,"metacyc":"FORMAMIDASE-RXN","compounds":"formamide + H2O <=> formate + NH4(+)"}
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{"X":436,"KEGG":"R00526","RHEA_ID":22043,"DIRECTION":"BI","MASTER_ID":22040,"compounds":"H2O + N-formyl-L-aspartate <=> formate + L-aspartate","pmd":27.995}
{"X":437,"KEGG":"R00527","RHEA_ID":14964,"DIRECTION":"BI","MASTER_ID":14961,"compounds":"H2O + S-formylglutathione <=> formate + glutathione + H(+)","pmd":27.995}
{"X":438,"KEGG":"R00528","RHEA_ID":14284,"DIRECTION":"BI","MASTER_ID":14281,"compounds":"2 [Fe(III)cytochrome c] + H2O + sulfite <=> 2 [Fe(II)cytochrome c] + 2 H(+) + sulfate"}
{"X":439,"KEGG":"R00529","RHEA_ID":18136,"DIRECTION":"BI","MASTER_ID":18133,"ecocyc":"SULFATE-ADENYLYLTRANS-RXN","metacyc":"SULFATE-ADENYLYLTRANS-RXN","compounds":"ATP + H(+) + sulfate <=> adenosine 5'-phosphosulfate + diphosphate","pmd":79.976}
{"X":440,"KEGG":"R00530","RHEA_ID":16532,"DIRECTION":"BI","MASTER_ID":16529,"compounds":"ADP + H(+) + sulfate <=> adenosine 5'-phosphosulfate + phosphate","pmd":0.01}
{"X":441,"KEGG":"R00531","RHEA_ID":17044,"DIRECTION":"BI","MASTER_ID":17041,"compounds":"adenosine 5'-phosphosulfate + H2O <=> AMP + 2 H(+) + sulfate","pmd":79.957}
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{"X":443,"KEGG":"R00533","RHEA_ID":24603,"DIRECTION":"BI","MASTER_ID":24600,"compounds":"H2O + O2 + sulfite <=> H2O2 + sulfate"}
{"X":444,"KEGG":"R00534","RHEA_ID":19148,"DIRECTION":"BI","MASTER_ID":19145,"compounds":"D-glucose 6-sulfate + H2O <=> D-glucose + H(+) + sulfate","pmd":79.957}
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{"X":446,"KEGG":"R00539","RHEA_ID":14968,"DIRECTION":"BI","MASTER_ID":14965,"compounds":"an acyl phosphate + H2O <=> a carboxylate + H(+) + phosphate"}
{"X":447,"KEGG":"R00540","RHEA_ID":21727,"DIRECTION":"BI","MASTER_ID":21724,"compounds":"a nitrile + 2 H2O <=> a carboxylate + NH4(+)"}
{"X":448,"KEGG":"R00542","RHEA_ID":16840,"DIRECTION":"BI","MASTER_ID":16837,"compounds":"5'-acylphosphoadenosine + H2O <=> a carboxylate + AMP + 2 H(+)"}
{"X":449,"KEGG":"R00543","RHEA_ID":19012,"DIRECTION":"BI","MASTER_ID":19009,"compounds":"a 3-acylpyruvate + H2O <=> a carboxylate + H(+) + pyruvate"}
{"X":450,"KEGG":"R00544","RHEA_ID":56859,"DIRECTION":"BI","MASTER_ID":56856,"ecocyc":"CARBOXYLATE-REDUCTASE-RXN","metacyc":"CARBOXYLATE-REDUCTASE-RXN","compounds":"A + an aldehyde + H2O <=> a carboxylate + AH2 + H(+)"}
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{"X":454,"KEGG":"R00548","RHEA_ID":35590,"DIRECTION":"BI","MASTER_ID":35587,"compounds":"FMN + H2O <=> phosphate + riboflavin","pmd":79.966}
{"X":455,"KEGG":"R00549","RHEA_ID":14360,"DIRECTION":"BI","MASTER_ID":14357,"compounds":"ATP + riboflavin <=> ADP + FMN + H(+)","pmd":50.891}
{"X":456,"KEGG":"R00550","RHEA_ID":20412,"DIRECTION":"BI","MASTER_ID":20409,"compounds":"alpha-D-glucose 1-phosphate + riboflavin <=> D-glucose + FMN","pmd":79.966}
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{"X":459,"KEGG":"R00554","RHEA_ID":22943,"DIRECTION":"BI","MASTER_ID":22940,"metacyc":"ARGININE-KINASE-RXN","compounds":"ATP + L-arginine <=> ADP + H(+) + N(omega)-phospho-L-arginine","pmd":79.966}
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{"X":461,"KEGG":"R00557","RHEA_ID":19900,"DIRECTION":"BI","MASTER_ID":19897,"compounds":"H(+) + 2 L-arginine + 3 NADPH + 4 O2 <=> 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide","pmd":0.984}
{"X":462,"KEGG":"R00557","RHEA_ID":19900,"DIRECTION":"BI","MASTER_ID":19897,"compounds":"H(+) + 2 L-arginine + 3 NADPH + 4 O2 <=> 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide","pmd":569.995}
{"X":463,"KEGG":"R00558","RHEA_ID":24663,"DIRECTION":"BI","MASTER_ID":24660,"compounds":"H(+) + L-arginine + NADPH + O2 <=> H2O + N(omega)-hydroxy-L-arginine + NADP(+)","pmd":15.995}
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{"X":465,"KEGG":"R00559","RHEA_ID":10551,"DIRECTION":"BI","MASTER_ID":10548,"compounds":"L-arginine + O2 <=> 4-guanidinobutanamide + CO2 + H2O","pmd":30.011}
{"X":466,"KEGG":"R00562","RHEA_ID":16288,"DIRECTION":"BI","MASTER_ID":16285,"compounds":"D-octopine + H2O + NAD(+) <=> H(+) + L-arginine + NADH + pyruvate","pmd":72.021}
{"X":467,"KEGG":"R00562","RHEA_ID":16288,"DIRECTION":"BI","MASTER_ID":16285,"compounds":"D-octopine + H2O + NAD(+) <=> H(+) + L-arginine + NADH + pyruvate","pmd":490.005}
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{"X":471,"KEGG":"R00566","RHEA_ID":17644,"DIRECTION":"BI","MASTER_ID":17641,"metacyc":"ARGDECARBOX-RXN","compounds":"H(+) + L-arginine <=> agmatine + CO2","pmd":43.99}
{"X":472,"KEGG":"R00567","RHEA_ID":18072,"DIRECTION":"BI","MASTER_ID":18069,"metacyc":"ARGININE-RACEMASE-RXN","compounds":"L-arginine <=> D-arginine","pmd":0}
{"X":473,"KEGG":"R00568","RHEA_ID":30338,"DIRECTION":"BI","MASTER_ID":30335,"compounds":"CTP + H(+) + H2O <=> NH4(+) + UTP","pmd":0.984}
{"X":474,"KEGG":"R00570","RHEA_ID":25240,"DIRECTION":"BI","MASTER_ID":25237,"compounds":"ATP + CDP <=> ADP + CTP","pmd":24.011}
{"X":475,"KEGG":"R00571","RHEA_ID":16600,"DIRECTION":"BI","MASTER_ID":16597,"compounds":"ATP + NH4(+) + UTP <=> ADP + CTP + 2 H(+) + phosphate","pmd":0.984}
{"X":476,"KEGG":"R00571","RHEA_ID":16600,"DIRECTION":"BI","MASTER_ID":16597,"compounds":"ATP + NH4(+) + UTP <=> ADP + CTP + 2 H(+) + phosphate","pmd":24.011}
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{"X":478,"KEGG":"R00573","RHEA_ID":26429,"DIRECTION":"BI","MASTER_ID":26426,"compounds":"ATP + H2O + L-glutamine + UTP <=> ADP + CTP + 2 H(+) + L-glutamate + phosphate","pmd":24.011}
{"X":479,"KEGG":"R00573","RHEA_ID":26429,"DIRECTION":"BI","MASTER_ID":26426,"compounds":"ATP + H2O + L-glutamine + UTP <=> ADP + CTP + 2 H(+) + L-glutamate + phosphate","pmd":0.984}
{"X":480,"KEGG":"R00574","RHEA_ID":14740,"DIRECTION":"BI","MASTER_ID":14737,"compounds":"CTP <=> 3',5'-cyclic CMP + diphosphate","pmd":177.943}
{"X":481,"KEGG":"R00575","RHEA_ID":18636,"DIRECTION":"BI","MASTER_ID":18633,"compounds":"2 ATP + H2O + hydrogencarbonate + L-glutamine <=> 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate","pmd":0.984}
{"X":482,"KEGG":"R00575","RHEA_ID":18636,"DIRECTION":"BI","MASTER_ID":18633,"compounds":"2 ATP + H2O + hydrogencarbonate + L-glutamine <=> 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate","pmd":79.966}
{"X":483,"KEGG":"R00576","RHEA_ID":10403,"DIRECTION":"BI","MASTER_ID":10400,"metacyc":"GLUTAMINE--PYRUVATE-AMINOTRANSFERASE-RXN","compounds":"L-glutamine + pyruvate <=> 2-oxoglutaramate + L-alanine","pmd":1.032}
{"X":484,"KEGG":"R00577","RHEA_ID":18472,"DIRECTION":"BI","MASTER_ID":18469,"metacyc":"GLUTAMINE-N-ACYLTRANSFERASE-RXN","compounds":"an acyl-CoA + L-glutamine <=> an N(2)-acyl-L-glutamine + CoA + H(+)","pmd":621.046}
{"X":485,"KEGG":"R00578","RHEA_ID":12231,"DIRECTION":"BI","MASTER_ID":12228,"compounds":"ATP + H2O + L-aspartate + L-glutamine <=> AMP + diphosphate + H(+) + L-asparagine + L-glutamate","pmd":0.984}
{"X":486,"KEGG":"R00578","RHEA_ID":12231,"DIRECTION":"BI","MASTER_ID":12228,"compounds":"ATP + H2O + L-aspartate + L-glutamine <=> AMP + diphosphate + H(+) + L-asparagine + L-glutamate","pmd":159.933}
{"X":487,"KEGG":"R00579","RHEA_ID":59279,"DIRECTION":"BI","MASTER_ID":59276,"compounds":"L-glutamine <=> D-glutamine","pmd":0}
{"X":488,"KEGG":"R00581","RHEA_ID":20887,"DIRECTION":"BI","MASTER_ID":20884,"compounds":"H2O + L-serine + NAD(+) <=> 3-hydroxypyruvate + H(+) + NADH + NH4(+)","pmd":1.032}
{"X":489,"KEGG":"R00581","RHEA_ID":20887,"DIRECTION":"BI","MASTER_ID":20884,"compounds":"H2O + L-serine + NAD(+) <=> 3-hydroxypyruvate + H(+) + NADH + NH4(+)","pmd":560.106}
{"X":490,"KEGG":"R00582","RHEA_ID":21211,"DIRECTION":"BI","MASTER_ID":21208,"compounds":"H2O + O-phospho-L-serine <=> L-serine + phosphate","pmd":79.966}
{"X":491,"KEGG":"R00584","RHEA_ID":23767,"DIRECTION":"BI","MASTER_ID":23764,"compounds":"diphosphate + L-serine <=> H(+) + O-phospho-L-serine + phosphate","pmd":79.966}
{"X":492,"KEGG":"R00585","RHEA_ID":22855,"DIRECTION":"BI","MASTER_ID":22852,"metacyc":"SERINE--PYRUVATE-AMINOTRANSFERASE-RXN","compounds":"L-serine + pyruvate <=> 3-hydroxypyruvate + L-alanine","pmd":1.032}
{"X":493,"KEGG":"R00586","RHEA_ID":24563,"DIRECTION":"BI","MASTER_ID":24560,"ecocyc":"SERINE-O-ACETTRAN-RXN","metacyc":"SERINE-O-ACETTRAN-RXN","compounds":"acetyl-CoA + L-serine <=> CoA + O-acetyl-L-serine","pmd":42.011}
{"X":494,"KEGG":"R00588","RHEA_ID":19128,"DIRECTION":"BI","MASTER_ID":19125,"metacyc":"SERINE--GLYOXYLATE-AMINOTRANSFERASE-RXN","compounds":"glyoxylate + L-serine <=> 3-hydroxypyruvate + glycine","pmd":1.032}
{"X":495,"KEGG":"R00589","RHEA_ID":10983,"DIRECTION":"BI","MASTER_ID":10980,"compounds":"L-serine <=> D-serine","pmd":0}
{"X":496,"KEGG":"R00590","RHEA_ID":40666,"DIRECTION":"BI","MASTER_ID":40663,"compounds":"L-serine <=> 2-aminoprop-2-enoate + H2O"}
{"X":497,"KEGG":"R00594","RHEA_ID":42715,"DIRECTION":"BI","MASTER_ID":42712,"compounds":"S-adenosyl-L-methionine + uridine(54) in tRNA <=> 5-methyluridine(54) in tRNA + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":498,"KEGG":"R00595","RHEA_ID":42955,"DIRECTION":"BI","MASTER_ID":42952,"compounds":"cytidine(49) in tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(49) in tRNA + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":499,"KEGG":"R00595","RHEA_ID":42943,"DIRECTION":"BI","MASTER_ID":42940,"compounds":"cytidine(34) in tRNA precursor + S-adenosyl-L-methionine <=> 5-methylcytidine(34) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":500,"KEGG":"R00595","RHEA_ID":42959,"DIRECTION":"BI","MASTER_ID":42956,"compounds":"cytidine(38) in tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(38) in tRNA + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":501,"KEGG":"R00595","RHEA_ID":42951,"DIRECTION":"BI","MASTER_ID":42948,"compounds":"cytidine(48) in tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(48) in tRNA + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":502,"KEGG":"R00595","RHEA_ID":42947,"DIRECTION":"BI","MASTER_ID":42944,"compounds":"cytidine(40) in tRNA precursor + S-adenosyl-L-methionine <=> 5-methylcytidine(40) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":503,"KEGG":"R00597","RHEA_ID":36902,"DIRECTION":"BI","MASTER_ID":36899,"compounds":"guanosine(37) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":504,"KEGG":"R00599","RHEA_ID":16788,"DIRECTION":"BI","MASTER_ID":16785,"compounds":"an adenosine in tRNA + S-adenosyl-L-methionine <=> an N(6)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":505,"KEGG":"R00600","RHEA_ID":42711,"DIRECTION":"BI","MASTER_ID":42708,"compounds":"guanosine(46) in tRNA + S-adenosyl-L-methionine <=> N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":506,"KEGG":"R00601","RHEA_ID":19572,"DIRECTION":"BI","MASTER_ID":19569,"compounds":"5-aminomethyl-2-thiouridine(34) in tRNA + S-adenosyl-L-methionine <=> 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":507,"KEGG":"R00602","RHEA_ID":30694,"DIRECTION":"BI","MASTER_ID":30691,"compounds":"H2O2 + methanol <=> formaldehyde + 2 H2O"}
{"X":508,"KEGG":"R00603","RHEA_ID":15400,"DIRECTION":"BI","MASTER_ID":15397,"metacyc":"DICHLOROMETHANE-DEHALOGENASE-RXN","compounds":"dichloromethane + H2O <=> 2 chloride + formaldehyde + 2 H(+)"}
{"X":509,"KEGG":"R00604","RHEA_ID":16428,"DIRECTION":"BI","MASTER_ID":16425,"compounds":"formaldehyde + H2O + NAD(+) <=> formate + 2 H(+) + NADH"}
{"X":510,"KEGG":"R00605","RHEA_ID":19404,"DIRECTION":"BI","MASTER_ID":19401,"compounds":"methanol + NAD(+) <=> formaldehyde + H(+) + NADH"}
{"X":511,"KEGG":"R00606","RHEA_ID":30210,"DIRECTION":"BI","MASTER_ID":30207,"compounds":"H2O + methylamine + 2 oxidized [amicyanin] <=> formaldehyde + 2 H(+) + NH4(+) + 2 reduced [amicyanin]"}
{"X":512,"KEGG":"R00609","RHEA_ID":22575,"DIRECTION":"BI","MASTER_ID":22572,"compounds":"A + H2O + N-methyl-L-glutamate <=> AH2 + formaldehyde + L-glutamate","pmd":14.016}
{"X":513,"KEGG":"R00610","RHEA_ID":13316,"DIRECTION":"BI","MASTER_ID":13313,"compounds":"H2O + O2 + sarcosine <=> formaldehyde + glycine + H2O2"}
{"X":514,"KEGG":"R00611","RHEA_ID":19796,"DIRECTION":"BI","MASTER_ID":19793,"compounds":"H(+) + H2O + oxidized [electron-transfer flavoprotein] + sarcosine <=> formaldehyde + glycine + reduced [electron-transfer flavoprotein]"}
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{"X":726,"KEGG":"R00842","RHEA_ID":11095,"DIRECTION":"BI","MASTER_ID":11092,"compounds":"NAD(+) + sn-glycerol 3-phosphate <=> dihydroxyacetone phosphate + H(+) + NADH","pmd":2.016}
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{"X":734,"KEGG":"R00849","RHEA_ID":18980,"DIRECTION":"BI","MASTER_ID":18977,"compounds":"a quinone + sn-glycerol 3-phosphate <=> a quinol + dihydroxyacetone phosphate","pmd":2.016}
{"X":735,"KEGG":"R00850","RHEA_ID":21291,"DIRECTION":"BI","MASTER_ID":21288,"compounds":"D-glucose + sn-glycerol 3-phosphate <=> D-glucose 6-phosphate + glycerol","pmd":88.016}
{"X":736,"KEGG":"R00850","RHEA_ID":21291,"DIRECTION":"BI","MASTER_ID":21288,"compounds":"D-glucose + sn-glycerol 3-phosphate <=> D-glucose 6-phosphate + glycerol","pmd":79.966}
{"X":737,"KEGG":"R00851","RHEA_ID":15328,"DIRECTION":"BI","MASTER_ID":15325,"compounds":"an acyl-CoA + sn-glycerol 3-phosphate <=> a 1-acyl-sn-glycero-3-phosphate + CoA","pmd":595.101}
{"X":738,"KEGG":"R00853","RHEA_ID":14288,"DIRECTION":"BI","MASTER_ID":14285,"compounds":"sn-glycerol 3-phosphate + UDP-alpha-D-galactose <=> 2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate + H(+) + UDP","pmd":162.053}
{"X":739,"KEGG":"R00854","RHEA_ID":20344,"DIRECTION":"BI","MASTER_ID":20341,"compounds":"sn-glycerol 3-phosphate + UDP-alpha-D-galactose <=> 1-O-alpha-D-galactosyl-sn-glycerol 3-phosphate + H(+) + UDP","pmd":162.053}
{"X":740,"KEGG":"R00855","RHEA_ID":21695,"DIRECTION":"BI","MASTER_ID":21692,"metacyc":"CDP-GLYCEROL-PYROPHOSPHATASE-RXN","compounds":"CDP-glycerol + H2O <=> CMP + 2 H(+) + sn-glycerol 3-phosphate","pmd":154.003}
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{"X":742,"KEGG":"R00856","RHEA_ID":13364,"DIRECTION":"BI","MASTER_ID":13361,"compounds":"CTP + H(+) + sn-glycerol 3-phosphate <=> CDP-glycerol + diphosphate","pmd":5.93}
{"X":743,"KEGG":"R00857","RHEA_ID":12972,"DIRECTION":"BI","MASTER_ID":12969,"compounds":"a sn-glycero-3-phosphoester + H2O <=> an alcohol + H(+) + sn-glycerol 3-phosphate"}
{"X":744,"KEGG":"R00858","RHEA_ID":13804,"DIRECTION":"BI","MASTER_ID":13801,"compounds":"3 H2O + hydrogen sulfide + 3 NADP(+) <=> 4 H(+) + 3 NADPH + sulfite"}
{"X":745,"KEGG":"R00859","RHEA_ID":23135,"DIRECTION":"BI","MASTER_ID":23132,"compounds":"3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] <=> 7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite"}
{"X":746,"KEGG":"R00860","RHEA_ID":24243,"DIRECTION":"BI","MASTER_ID":24240,"metacyc":"ADENYLYLSULFATE-REDUCTASE-RXN","compounds":"A + AMP + 2 H(+) + sulfite <=> adenosine 5'-phosphosulfate + AH2","pmd":79.957}
{"X":747,"KEGG":"R00863","RHEA_ID":28281,"DIRECTION":"BI","MASTER_ID":28278,"ecocyc":"RXN0-279","metacyc":"RXN0-279","compounds":"3-sulfino-L-alanine + H2O <=> H(+) + L-alanine + sulfite"}
{"X":748,"KEGG":"R00865","RHEA_ID":17600,"DIRECTION":"BI","MASTER_ID":17597,"compounds":"2 [Fe(III)cytochrome c] + D-mannitol <=> 2 [Fe(II)cytochrome c] + D-fructose + 2 H(+)","pmd":2.016}
{"X":749,"KEGG":"R00866","RHEA_ID":18148,"DIRECTION":"BI","MASTER_ID":18145,"compounds":"ATP + beta-D-fructose <=> ADP + beta-D-fructose 1-phosphate + H(+)","pmd":79.966}
{"X":750,"KEGG":"R00868","RHEA_ID":12087,"DIRECTION":"BI","MASTER_ID":12084,"metacyc":"MANNITOL-2-DEHYDROGENASE-RXN","compounds":"D-mannitol + NAD(+) <=> D-fructose + H(+) + NADH","pmd":2.016}
{"X":751,"KEGG":"R00868","RHEA_ID":12087,"DIRECTION":"BI","MASTER_ID":12084,"metacyc":"MANNITOL-2-DEHYDROGENASE-RXN","compounds":"D-mannitol + NAD(+) <=> D-fructose + H(+) + NADH","pmd":484.053}
{"X":752,"KEGG":"R00870","RHEA_ID":16768,"DIRECTION":"BI","MASTER_ID":16765,"metacyc":"MANNITOL-2-DEHYDROGENASE-NADP%2b-RXN","compounds":"D-mannitol + NADP(+) <=> D-fructose + H(+) + NADPH","pmd":2.016}
{"X":753,"KEGG":"R00870","RHEA_ID":16768,"DIRECTION":"BI","MASTER_ID":16765,"metacyc":"MANNITOL-2-DEHYDROGENASE-NADP%2b-RXN","compounds":"D-mannitol + NADP(+) <=> D-fructose + H(+) + NADPH","pmd":564.02}
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{"X":755,"KEGG":"R00871","RHEA_ID":14072,"DIRECTION":"BI","MASTER_ID":14069,"metacyc":"FRUCTOSE-5-DEHYDROGENASE-NADP%2b-RXN","compounds":"D-fructose + NADP(+) <=> 5-dehydro-D-fructose + H(+) + NADPH","pmd":566.036}
{"X":756,"KEGG":"R00873","RHEA_ID":22307,"DIRECTION":"BI","MASTER_ID":22304,"metacyc":"FRUCTOSE-5-DEHYDROGENASE-RXN","compounds":"A + D-fructose <=> 5-dehydro-D-fructose + AH2","pmd":2.016}
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{"X":758,"KEGG":"R00875","RHEA_ID":33034,"DIRECTION":"BI","MASTER_ID":33031,"metacyc":"RXN-7644","compounds":"D-fructose + H(+) + NADH <=> D-sorbitol + NAD(+)","pmd":484.053}
{"X":759,"KEGG":"R00875","RHEA_ID":33034,"DIRECTION":"BI","MASTER_ID":33031,"metacyc":"RXN-7644","compounds":"D-fructose + H(+) + NADH <=> D-sorbitol + NAD(+)","pmd":2.016}
{"X":760,"KEGG":"R00877","RHEA_ID":22607,"DIRECTION":"BI","MASTER_ID":22604,"metacyc":"MANNOSE-ISOMERASE-RXN","compounds":"D-mannose <=> D-fructose","pmd":0}
{"X":761,"KEGG":"R00878","RHEA_ID":28549,"DIRECTION":"BI","MASTER_ID":28546,"metacyc":"GLUCISOM-RXN","compounds":"D-glucose <=> D-fructose","pmd":0}
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{"X":763,"KEGG":"R00880","RHEA_ID":21731,"DIRECTION":"BI","MASTER_ID":21728,"compounds":"GDP-alpha-D-mannose + H2O + 2 NAD(+) <=> GDP-alpha-D-mannuronate + 3 H(+) + 2 NADH","pmd":13.979}
{"X":764,"KEGG":"R00881","RHEA_ID":27981,"DIRECTION":"BI","MASTER_ID":27978,"ecocyc":"RXN0-5108","metacyc":"RXN0-5108","compounds":"GDP-alpha-D-mannose + H2O <=> alpha-D-mannose 1-phosphate + GMP + 2 H(+)","pmd":242.019}
{"X":765,"KEGG":"R00883","RHEA_ID":12908,"DIRECTION":"BI","MASTER_ID":12905,"compounds":"alpha-D-mannose 1-phosphate + GDP + H(+) <=> GDP-alpha-D-mannose + phosphate","pmd":345.047}
{"X":766,"KEGG":"R00883","RHEA_ID":12908,"DIRECTION":"BI","MASTER_ID":12905,"compounds":"alpha-D-mannose 1-phosphate + GDP + H(+) <=> GDP-alpha-D-mannose + phosphate","pmd":162.053}
{"X":767,"KEGG":"R00885","RHEA_ID":15232,"DIRECTION":"BI","MASTER_ID":15229,"compounds":"alpha-D-mannose 1-phosphate + GTP + H(+) <=> diphosphate + GDP-alpha-D-mannose","pmd":82.087}
{"X":768,"KEGG":"R00885","RHEA_ID":15232,"DIRECTION":"BI","MASTER_ID":15229,"compounds":"alpha-D-mannose 1-phosphate + GTP + H(+) <=> diphosphate + GDP-alpha-D-mannose","pmd":345.047}
{"X":769,"KEGG":"R00888","RHEA_ID":23823,"DIRECTION":"BI","MASTER_ID":23820,"compounds":"GDP-alpha-D-mannose <=> GDP-4-dehydro-alpha-D-rhamnose + H2O","pmd":18.011}
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{"X":772,"KEGG":"R00892","RHEA_ID":20600,"DIRECTION":"BI","MASTER_ID":20597,"compounds":"2 L-cysteine + NAD(+) <=> H(+) + L-cystine + NADH","pmd":119.004}
{"X":773,"KEGG":"R00893","RHEA_ID":20444,"DIRECTION":"BI","MASTER_ID":20441,"compounds":"L-cysteine + O2 <=> 3-sulfino-L-alanine + H(+)","pmd":31.99}
{"X":774,"KEGG":"R00894","RHEA_ID":13288,"DIRECTION":"BI","MASTER_ID":13285,"compounds":"ATP + L-cysteine + L-glutamate <=> ADP + H(+) + L-gamma-glutamyl-L-cysteine + phosphate","pmd":79.966}
{"X":775,"KEGG":"R00894","RHEA_ID":13288,"DIRECTION":"BI","MASTER_ID":13285,"compounds":"ATP + L-cysteine + L-glutamate <=> ADP + H(+) + L-gamma-glutamyl-L-cysteine + phosphate","pmd":129.043}
{"X":776,"KEGG":"R00894","RHEA_ID":13288,"DIRECTION":"BI","MASTER_ID":13285,"compounds":"ATP + L-cysteine + L-glutamate <=> ADP + H(+) + L-gamma-glutamyl-L-cysteine + phosphate","pmd":103.009}
{"X":777,"KEGG":"R00895","RHEA_ID":17444,"DIRECTION":"BI","MASTER_ID":17441,"metacyc":"CYSTEINE-AMINOTRANSFERASE-RXN","compounds":"2-oxoglutarate + L-cysteine <=> 3-mercaptopyruvate + L-glutamate","pmd":1.032}
{"X":778,"KEGG":"R00897","RHEA_ID":14832,"DIRECTION":"BI","MASTER_ID":14829,"ecocyc":"ACSERLY-RXN","metacyc":"ACSERLY-RXN","compounds":"hydrogen sulfide + O-acetyl-L-serine <=> acetate + L-cysteine","pmd":26.034}
{"X":779,"KEGG":"R00899","RHEA_ID":28786,"DIRECTION":"BI","MASTER_ID":28783,"compounds":"H2O + L-cysteinylglycine <=> glycine + L-cysteine","pmd":57.022}
{"X":780,"KEGG":"R00901","RHEA_ID":20919,"DIRECTION":"BI","MASTER_ID":20916,"compounds":"L-cysteine + sulfite <=> hydrogen sulfide + L-cysteate","pmd":47.985}
{"X":781,"KEGG":"R00903","RHEA_ID":59275,"DIRECTION":"BI","MASTER_ID":59272,"compounds":"L-cysteine <=> D-cysteine","pmd":0}
{"X":782,"KEGG":"R00904","RHEA_ID":30698,"DIRECTION":"BI","MASTER_ID":30695,"compounds":"3-aminopropanal + H2O + NAD(+) <=> beta-alanine + 2 H(+) + NADH"}
{"X":783,"KEGG":"R00905","RHEA_ID":11187,"DIRECTION":"BI","MASTER_ID":11184,"compounds":"3-(carbamoylamino)propanoate + 2 H(+) + H2O <=> beta-alanine + CO2 + NH4(+)"}
{"X":784,"KEGG":"R00906","RHEA_ID":21687,"DIRECTION":"BI","MASTER_ID":21684,"compounds":"(R)-beta-alanopine + H2O + NAD(+) <=> beta-alanine + H(+) + NADH + pyruvate","pmd":504.056}
{"X":785,"KEGG":"R00907","RHEA_ID":14080,"DIRECTION":"BI","MASTER_ID":14077,"metacyc":"2.6.1.18-RXN","compounds":"3-oxopropanoate + L-alanine <=> beta-alanine + pyruvate"}
{"X":786,"KEGG":"R00908","RHEA_ID":30702,"DIRECTION":"BI","MASTER_ID":30699,"compounds":"2-oxoglutarate + beta-alanine <=> 3-oxopropanoate + L-glutamate","pmd":1.032}
{"X":787,"KEGG":"R00909","RHEA_ID":23215,"DIRECTION":"BI","MASTER_ID":23212,"compounds":"H2O + N-acetyl-beta-alanine <=> acetate + beta-alanine"}
{"X":788,"KEGG":"R00910","RHEA_ID":59587,"DIRECTION":"BI","MASTER_ID":59584,"compounds":"ATP + beta-alanine + L-lysine <=> ADP + beta-alanyl-L-lysine + H(+) + phosphate","pmd":71.037}
{"X":789,"KEGG":"R00910","RHEA_ID":59587,"DIRECTION":"BI","MASTER_ID":59584,"compounds":"ATP + beta-alanine + L-lysine <=> ADP + beta-alanyl-L-lysine + H(+) + phosphate","pmd":79.966}
{"X":790,"KEGG":"R00911","RHEA_ID":59611,"DIRECTION":"BI","MASTER_ID":59608,"compounds":"beta-alanyl-L-lysine + H2O <=> beta-alanine + L-lysine","pmd":71.037}
{"X":791,"KEGG":"R00912","RHEA_ID":59595,"DIRECTION":"BI","MASTER_ID":59592,"compounds":"ATP + beta-alanine + L-arginine <=> ADP + beta-alanyl-L-arginine + H(+) + phosphate","pmd":71.037}
{"X":792,"KEGG":"R00912","RHEA_ID":59595,"DIRECTION":"BI","MASTER_ID":59592,"compounds":"ATP + beta-alanine + L-arginine <=> ADP + beta-alanyl-L-arginine + H(+) + phosphate","pmd":79.966}
{"X":793,"KEGG":"R00913","RHEA_ID":16032,"DIRECTION":"BI","MASTER_ID":16029,"metacyc":"GUANIDINOPROPIONASE-RXN","compounds":"3-guanidinopropanoate + H2O <=> beta-alanine + urea"}
{"X":794,"KEGG":"R00918","RHEA_ID":23071,"DIRECTION":"BI","MASTER_ID":23068,"compounds":"6 (S)-methylmalonyl-CoA + 12 H(+) + 6 NADPH + propanoyl-CoA <=> 6-deoxyerythronolide B + 6 CO2 + 7 CoA + H2O + 6 NADP(+)","pmd":22.024}
{"X":795,"KEGG":"R00918","RHEA_ID":23071,"DIRECTION":"BI","MASTER_ID":23068,"compounds":"6 (S)-methylmalonyl-CoA + 12 H(+) + 6 NADPH + propanoyl-CoA <=> 6-deoxyerythronolide B + 6 CO2 + 7 CoA + H2O + 6 NADP(+)","pmd":56.026}
{"X":796,"KEGG":"R00918","RHEA_ID":23071,"DIRECTION":"BI","MASTER_ID":23068,"compounds":"6 (S)-methylmalonyl-CoA + 12 H(+) + 6 NADPH + propanoyl-CoA <=> 6-deoxyerythronolide B + 6 CO2 + 7 CoA + H2O + 6 NADP(+)","pmd":100.016}
{"X":797,"KEGG":"R00920","RHEA_ID":29846,"DIRECTION":"BI","MASTER_ID":29843,"metacyc":"PROPANOATECOA-LIGASE-RXN","compounds":"ATP + CoA + propanoate <=> ADP + phosphate + propanoyl-CoA","pmd":56.026}
{"X":798,"KEGG":"R00920","RHEA_ID":29846,"DIRECTION":"BI","MASTER_ID":29843,"metacyc":"PROPANOATECOA-LIGASE-RXN","compounds":"ATP + CoA + propanoate <=> ADP + phosphate + propanoyl-CoA","pmd":79.966}
{"X":799,"KEGG":"R00921","RHEA_ID":28049,"DIRECTION":"BI","MASTER_ID":28046,"compounds":"phosphate + propanoyl-CoA <=> CoA + propanoyl phosphate","pmd":56.026}
{"X":800,"KEGG":"R00922","RHEA_ID":20807,"DIRECTION":"BI","MASTER_ID":20804,"compounds":"2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) <=> H(+) + hydrogencarbonate + NADH + propanoyl-CoA","pmd":159.024}
{"X":801,"KEGG":"R00922","RHEA_ID":20807,"DIRECTION":"BI","MASTER_ID":20804,"compounds":"2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) <=> H(+) + hydrogencarbonate + NADH + propanoyl-CoA","pmd":56.026}
{"X":802,"KEGG":"R00922","RHEA_ID":20807,"DIRECTION":"BI","MASTER_ID":20804,"compounds":"2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) <=> H(+) + hydrogencarbonate + NADH + propanoyl-CoA","pmd":563.093}
{"X":803,"KEGG":"R00923","RHEA_ID":21399,"DIRECTION":"BI","MASTER_ID":21396,"metacyc":"RXN-19738","compounds":"(S)-methylmalonyl-CoA + H(+)(out) + Na(+)(in) <=> CO2 + Na(+)(out) + propanoyl-CoA","pmd":43.99}
{"X":804,"KEGG":"R00923","RHEA_ID":61343,"DIRECTION":"BI","MASTER_ID":61340,"compounds":"(S)-methylmalonyl-CoA + H(+) <=> CO2 + propanoyl-CoA","pmd":43.99}
{"X":805,"KEGG":"R00925","RHEA_ID":20376,"DIRECTION":"BI","MASTER_ID":20373,"metacyc":"PROPIONATE--COA-LIGASE-RXN","compounds":"ATP + CoA + propanoate <=> AMP + diphosphate + propanoyl-CoA","pmd":159.933}
{"X":806,"KEGG":"R00925","RHEA_ID":20376,"DIRECTION":"BI","MASTER_ID":20373,"metacyc":"PROPIONATE--COA-LIGASE-RXN","compounds":"ATP + CoA + propanoate <=> AMP + diphosphate + propanoyl-CoA","pmd":56.026}
{"X":807,"KEGG":"R00927","RHEA_ID":30722,"DIRECTION":"BI","MASTER_ID":30719,"compounds":"acetyl-CoA + propanoyl-CoA <=> 2-methyl-3-oxobutanoyl-CoA + CoA","pmd":42.011}
{"X":808,"KEGG":"R00928","RHEA_ID":23523,"DIRECTION":"BI","MASTER_ID":23520,"metacyc":"PROPIONATE-COA-TRANSFERASE-RXN","compounds":"acetyl-CoA + propanoate <=> acetate + propanoyl-CoA","pmd":14.016}
{"X":809,"KEGG":"R00930","RHEA_ID":20767,"DIRECTION":"BI","MASTER_ID":20764,"metacyc":"2.1.3.1-RXN","compounds":"(S)-methylmalonyl-CoA + pyruvate <=> oxaloacetate + propanoyl-CoA","pmd":43.99}
{"X":810,"KEGG":"R00931","RHEA_ID":23783,"DIRECTION":"BI","MASTER_ID":23780,"metacyc":"2-METHYLCITRATE-SYNTHASE-RXN","compounds":"H2O + oxaloacetate + propanoyl-CoA <=> (2S,3S)-2-methylcitrate + CoA + H(+)","pmd":74.037}
{"X":811,"KEGG":"R00931","RHEA_ID":23783,"DIRECTION":"BI","MASTER_ID":23780,"metacyc":"2-METHYLCITRATE-SYNTHASE-RXN","compounds":"H2O + oxaloacetate + propanoyl-CoA <=> (2S,3S)-2-methylcitrate + CoA + H(+)","pmd":56.026}
{"X":812,"KEGG":"R00932","RHEA_ID":19188,"DIRECTION":"BI","MASTER_ID":19185,"compounds":"glyoxylate + H2O + propanoyl-CoA <=> 2-hydroxyglutarate + CoA + H(+)","pmd":56.026}
{"X":813,"KEGG":"R00932","RHEA_ID":19188,"DIRECTION":"BI","MASTER_ID":19185,"compounds":"glyoxylate + H2O + propanoyl-CoA <=> 2-hydroxyglutarate + CoA + H(+)","pmd":675.104}
{"X":814,"KEGG":"R00934","RHEA_ID":38262,"DIRECTION":"BI","MASTER_ID":38259,"metacyc":"RXN-8961","compounds":"(2R,3S)-beta-methylmalyl-CoA <=> glyoxylate + propanoyl-CoA","pmd":74}
{"X":815,"KEGG":"R00935","RHEA_ID":31050,"DIRECTION":"BI","MASTER_ID":31047,"compounds":"(S)-methylmalonate semialdehyde + CoA + NAD(+) <=> CO2 + NADH + propanoyl-CoA","pmd":159.024}
{"X":816,"KEGG":"R00935","RHEA_ID":31050,"DIRECTION":"BI","MASTER_ID":31047,"compounds":"(S)-methylmalonate semialdehyde + CoA + NAD(+) <=> CO2 + NADH + propanoyl-CoA","pmd":56.026}
{"X":817,"KEGG":"R00935","RHEA_ID":31050,"DIRECTION":"BI","MASTER_ID":31047,"compounds":"(S)-methylmalonate semialdehyde + CoA + NAD(+) <=> CO2 + NADH + propanoyl-CoA","pmd":563.093}
{"X":818,"KEGG":"R00939","RHEA_ID":15012,"DIRECTION":"BI","MASTER_ID":15009,"compounds":"(6S)-5,6,7,8-tetrahydrofolate + NADP(+) <=> 7,8-dihydrofolate + H(+) + NADPH","pmd":2.016}
{"X":819,"KEGG":"R00939","RHEA_ID":15012,"DIRECTION":"BI","MASTER_ID":15009,"compounds":"(6S)-5,6,7,8-tetrahydrofolate + NADP(+) <=> 7,8-dihydrofolate + H(+) + NADPH","pmd":300.928}
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{"X":841,"KEGG":"R00963","RHEA_ID":29362,"DIRECTION":"BI","MASTER_ID":29359,"compounds":"H2O + UMP <=> phosphate + uridine","pmd":79.966}
{"X":842,"KEGG":"R00964","RHEA_ID":16828,"DIRECTION":"BI","MASTER_ID":16825,"compounds":"ATP + uridine <=> ADP + H(+) + UMP","pmd":79.966}
{"X":843,"KEGG":"R00965","RHEA_ID":11599,"DIRECTION":"BI","MASTER_ID":11596,"compounds":"H(+) + orotidine 5'-phosphate <=> CO2 + UMP","pmd":43.99}
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{"X":846,"KEGG":"R00973","RHEA_ID":17688,"DIRECTION":"BI","MASTER_ID":17685,"compounds":"H(+) + uracil 5-carboxylate <=> CO2 + uracil","pmd":43.99}
{"X":847,"KEGG":"R00974","RHEA_ID":20608,"DIRECTION":"BI","MASTER_ID":20605,"compounds":"cytosine + H(+) + H2O <=> NH4(+) + uracil","pmd":0.984}
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{"X":851,"KEGG":"R00977","RHEA_ID":20192,"DIRECTION":"BI","MASTER_ID":20189,"ecocyc":"DIHYDROURACIL-DEHYDROGENASE-NAD%2b-RXN","metacyc":"DIHYDROURACIL-DEHYDROGENASE-NAD%2b-RXN","compounds":"5,6-dihydrouracil + NAD(+) <=> H(+) + NADH + uracil","pmd":2.016}
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{"X":856,"KEGG":"R00980","RHEA_ID":21239,"DIRECTION":"BI","MASTER_ID":21236,"compounds":"anthranilate + 2 H(+) + NADPH + O2 <=> 2,3-dihydroxybenzoate + NADP(+) + NH4(+)","pmd":16.979}
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{"X":858,"KEGG":"R00982","RHEA_ID":10831,"DIRECTION":"BI","MASTER_ID":10828,"compounds":"anthranilate + ATP + CoA <=> AMP + anthraniloyl-CoA + diphosphate","pmd":159.933}
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{"X":863,"KEGG":"R00986","RHEA_ID":21735,"DIRECTION":"BI","MASTER_ID":21732,"metacyc":"ANTHRANSYN-RXN","compounds":"chorismate + L-glutamine <=> anthranilate + H(+) + L-glutamate + pyruvate","pmd":0.984}
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{"X":874,"KEGG":"R01000","RHEA_ID":36374,"DIRECTION":"BI","MASTER_ID":36371,"compounds":"(2S)-hydroxybutanoate + NAD(+) <=> 2-oxobutanoate + H(+) + NADH","pmd":2.016}
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{"X":877,"KEGG":"R01004","RHEA_ID":14388,"DIRECTION":"BI","MASTER_ID":14385,"metacyc":"DOLICHYLDIPHOSPHATASE-RXN","compounds":"dolichyl diphosphate + H2O <=> dolichyl phosphate + H(+) + phosphate"}
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{"X":879,"KEGG":"R01006","RHEA_ID":13860,"DIRECTION":"BI","MASTER_ID":13857,"compounds":"dolichyl beta-D-glucosyl phosphate + H2O <=> D-glucose + dolichyl phosphate + H(+)"}
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{"X":881,"KEGG":"R01008","RHEA_ID":14696,"DIRECTION":"BI","MASTER_ID":14693,"metacyc":"2.4.1.153-RXN","compounds":"dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine <=> dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP","pmd":203.079}
{"X":882,"KEGG":"R01009","RHEA_ID":21187,"DIRECTION":"BI","MASTER_ID":21184,"compounds":"dolichyl phosphate + GDP-alpha-D-mannose <=> dolichyl beta-D-mannosyl phosphate + GDP","pmd":162.053}
{"X":883,"KEGG":"R01010","RHEA_ID":51731,"DIRECTION":"BI","MASTER_ID":51728,"compounds":"dihydroxyacetone phosphate + H2O <=> dihydroxyacetone + phosphate"}
{"X":884,"KEGG":"R01011","RHEA_ID":15776,"DIRECTION":"BI","MASTER_ID":15773,"compounds":"ATP + dihydroxyacetone <=> ADP + dihydroxyacetone phosphate + H(+)","pmd":79.966}
{"X":885,"KEGG":"R01012","RHEA_ID":18384,"DIRECTION":"BI","MASTER_ID":18381,"compounds":"dihydroxyacetone + phosphoenolpyruvate <=> dihydroxyacetone phosphate + pyruvate","pmd":2.016}
{"X":886,"KEGG":"R01013","RHEA_ID":17660,"DIRECTION":"BI","MASTER_ID":17657,"metacyc":"2.3.1.42-RXN","compounds":"an acyl-CoA + dihydroxyacetone phosphate <=> a 1-acylglycerone 3-phosphate + CoA","pmd":597.117}
{"X":887,"KEGG":"R01014","RHEA_ID":20935,"DIRECTION":"BI","MASTER_ID":20932,"compounds":"L-erythrulose 1-phosphate <=> dihydroxyacetone phosphate + formaldehyde","pmd":30.011}
{"X":888,"KEGG":"R01015","RHEA_ID":18588,"DIRECTION":"BI","MASTER_ID":18585,"ecocyc":"TRIOSEPISOMERIZATION-RXN","metacyc":"TRIOSEPISOMERIZATION-RXN","compounds":"D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate","pmd":0}
{"X":889,"KEGG":"R01016","RHEA_ID":17940,"DIRECTION":"BI","MASTER_ID":17937,"compounds":"dihydroxyacetone phosphate <=> methylglyoxal + phosphate"}
{"X":890,"KEGG":"R01018","RHEA_ID":13136,"DIRECTION":"BI","MASTER_ID":13133,"compounds":"CTP + di-trans,poly-cis-dolichol <=> CDP + dolichyl phosphate + H(+)","pmd":79.966}
{"X":891,"KEGG":"R01021","RHEA_ID":12840,"DIRECTION":"BI","MASTER_ID":12837,"compounds":"ATP + choline <=> ADP + H(+) + phosphocholine","pmd":79.966}
{"X":892,"KEGG":"R01022","RHEA_ID":13508,"DIRECTION":"BI","MASTER_ID":13505,"compounds":"choline + O2 <=> betaine aldehyde + H2O2","pmd":2.016}
{"X":893,"KEGG":"R01023","RHEA_ID":18824,"DIRECTION":"BI","MASTER_ID":18821,"metacyc":"CHOLINE-O-ACETYLTRANSFERASE-RXN","compounds":"acetyl-CoA + choline <=> acetylcholine + CoA","pmd":42.011}
{"X":894,"KEGG":"R01025","RHEA_ID":17436,"DIRECTION":"BI","MASTER_ID":17433,"metacyc":"CHD-RXN","compounds":"A + choline <=> AH2 + betaine aldehyde","pmd":2.016}
{"X":895,"KEGG":"R01026","RHEA_ID":17564,"DIRECTION":"BI","MASTER_ID":17561,"metacyc":"ACETYLCHOLINESTERASE-RXN","compounds":"acetylcholine + H2O <=> acetate + choline + H(+)","pmd":42.011}
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{"X":897,"KEGG":"R01027","RHEA_ID":21987,"DIRECTION":"BI","MASTER_ID":21984,"compounds":"3'-phosphoadenylyl sulfate + choline <=> adenosine 3',5'-bisphosphate + choline sulfate + H(+)","pmd":78.949}
{"X":898,"KEGG":"R01028","RHEA_ID":20823,"DIRECTION":"BI","MASTER_ID":20820,"compounds":"choline sulfate + H2O <=> choline + H(+) + sulfate","pmd":78.949}
{"X":899,"KEGG":"R01029","RHEA_ID":21967,"DIRECTION":"BI","MASTER_ID":21964,"compounds":"an acylcholine + H2O <=> a carboxylate + choline + H(+)"}
{"X":900,"KEGG":"R01030","RHEA_ID":16064,"DIRECTION":"BI","MASTER_ID":16061,"compounds":"H2O + sn-glycerol 3-phosphocholine <=> choline + H(+) + sn-glycerol 3-phosphate","pmd":86.097}
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{"X":902,"KEGG":"R01033","RHEA_ID":21655,"DIRECTION":"BI","MASTER_ID":21652,"compounds":"2-chlorobenzoate + H(+) + NADH + O2 <=> catechol + chloride + CO2 + NAD(+)","pmd":45.961}
{"X":903,"KEGG":"R01033","RHEA_ID":21655,"DIRECTION":"BI","MASTER_ID":21652,"compounds":"2-chlorobenzoate + H(+) + NADH + O2 <=> catechol + chloride + CO2 + NAD(+)","pmd":555.088}
{"X":904,"KEGG":"R01034","RHEA_ID":13772,"DIRECTION":"BI","MASTER_ID":13769,"ecocyc":"GLYCDEH-RXN","metacyc":"GLYCDEH-RXN","compounds":"glycerol + NAD(+) <=> dihydroxyacetone + H(+) + NADH"}
{"X":905,"KEGG":"R01036","RHEA_ID":30030,"DIRECTION":"BI","MASTER_ID":30027,"compounds":"D-glyceraldehyde + H(+) + NADH <=> glycerol + NAD(+)"}
{"X":906,"KEGG":"R01039","RHEA_ID":12756,"DIRECTION":"BI","MASTER_ID":12753,"metacyc":"GLYCEROL-2-DEHYDROGENASE-NADP%2b-RXN","compounds":"glycerol + NADP(+) <=> dihydroxyacetone + H(+) + NADPH"}
{"X":907,"KEGG":"R01041","RHEA_ID":23595,"DIRECTION":"BI","MASTER_ID":23592,"metacyc":"GLYCEROL-DEHYDROGENASE-NADP%2b-RXN","compounds":"glycerol + NADP(+) <=> D-glyceraldehyde + H(+) + NADPH"}
{"X":908,"KEGG":"R01043","RHEA_ID":13108,"DIRECTION":"BI","MASTER_ID":13105,"compounds":"glycerol 2-phosphate + H2O <=> glycerol + phosphate"}
{"X":909,"KEGG":"R01044","RHEA_ID":13692,"DIRECTION":"BI","MASTER_ID":13689,"compounds":"diphosphate + glycerol <=> glycerol 1-phosphate + H(+) + phosphate"}
{"X":910,"KEGG":"R01045","RHEA_ID":17496,"DIRECTION":"BI","MASTER_ID":17493,"metacyc":"GLYCEROL-DEHYDROGENASE-ACCEPTOR-RXN","compounds":"A + glycerol <=> AH2 + dihydroxyacetone"}
{"X":911,"KEGG":"R01047","RHEA_ID":19768,"DIRECTION":"BI","MASTER_ID":19765,"compounds":"glycerol <=> 3-hydroxypropanal + H2O"}
{"X":912,"KEGG":"R01049","RHEA_ID":15612,"DIRECTION":"BI","MASTER_ID":15609,"ecocyc":"PRPPSYN-RXN","metacyc":"PRPPSYN-RXN","compounds":"ATP + D-ribose 5-phosphate <=> 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)","pmd":117.044}
{"X":913,"KEGG":"R01050","RHEA_ID":21219,"DIRECTION":"BI","MASTER_ID":21216,"compounds":"ATP + D-ribose 5-phosphate <=> ADP + alpha-D-ribose 1,5-bisphosphate + H(+)","pmd":79.966}
{"X":914,"KEGG":"R01051","RHEA_ID":13700,"DIRECTION":"BI","MASTER_ID":13697,"compounds":"ATP + D-ribose <=> ADP + D-ribose 5-phosphate + H(+)","pmd":79.966}
{"X":915,"KEGG":"R01052","RHEA_ID":14532,"DIRECTION":"BI","MASTER_ID":14529,"compounds":"ADP + D-ribose 5-phosphate + H(+) <=> ADP-D-ribose + phosphate","pmd":329.052}
{"X":916,"KEGG":"R01052","RHEA_ID":14532,"DIRECTION":"BI","MASTER_ID":14529,"compounds":"ADP + D-ribose 5-phosphate + H(+) <=> ADP-D-ribose + phosphate","pmd":132.042}
{"X":917,"KEGG":"R01053","RHEA_ID":13780,"DIRECTION":"BI","MASTER_ID":13777,"compounds":"ATP + D-ribose 5-phosphate + NH4(+) <=> 5-phospho-D-ribosylamine + ADP + H(+) + phosphate","pmd":0.984}
{"X":918,"KEGG":"R01053","RHEA_ID":13780,"DIRECTION":"BI","MASTER_ID":13777,"compounds":"ATP + D-ribose 5-phosphate + NH4(+) <=> 5-phospho-D-ribosylamine + ADP + H(+) + phosphate","pmd":79.966}
{"X":919,"KEGG":"R01054","RHEA_ID":10415,"DIRECTION":"BI","MASTER_ID":10412,"compounds":"ADP-D-ribose + H2O <=> AMP + D-ribose 5-phosphate + 2 H(+)","pmd":212.009}
{"X":920,"KEGG":"R01055","RHEA_ID":18340,"DIRECTION":"BI","MASTER_ID":18337,"ecocyc":"RXN0-5398","metacyc":"RXN0-5398","compounds":"D-ribose 5-phosphate + uracil <=> H2O + psi-UMP","pmd":212.009}
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{"X":936,"KEGG":"R01069","RHEA_ID":22951,"DIRECTION":"BI","MASTER_ID":22948,"compounds":"D-tagatofuranose 1,6-bisphosphate <=> D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate","pmd":169.998}
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{"X":939,"KEGG":"R01072","RHEA_ID":14908,"DIRECTION":"BI","MASTER_ID":14905,"metacyc":"PRPPAMIDOTRANS-RXN","compounds":"5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate <=> 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine","pmd":82.966}
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{"X":941,"KEGG":"R01074","RHEA_ID":31118,"DIRECTION":"BI","MASTER_ID":31115,"compounds":"ATP + biotin + H(+) <=> biotinyl-5'-AMP + diphosphate","pmd":329.053}
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{"X":944,"KEGG":"R01075","RHEA_ID":19684,"DIRECTION":"BI","MASTER_ID":19681,"compounds":"ATP + biotin + CoA <=> AMP + biotinyl-CoA + diphosphate","pmd":159.933}
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{"X":948,"KEGG":"R01078","RHEA_ID":22063,"DIRECTION":"BI","MASTER_ID":22060,"compounds":"[sulfur carrier]-SH + dethiobiotin + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]","pmd":147.035}
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{"X":950,"KEGG":"R01079","RHEA_ID":11679,"DIRECTION":"BI","MASTER_ID":11676,"compounds":"D-ribose + H2O + NADP(+) <=> D-ribonate + 2 H(+) + NADPH","pmd":15.995}
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{"X":952,"KEGG":"R01081","RHEA_ID":20799,"DIRECTION":"BI","MASTER_ID":20796,"compounds":"aldehydo-D-ribose <=> D-ribulose","pmd":0}
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{"X":956,"KEGG":"R01086","RHEA_ID":24023,"DIRECTION":"BI","MASTER_ID":24020,"ecocyc":"ARGSUCCINLYA-RXN","metacyc":"ARGSUCCINLYA-RXN","compounds":"2-(N(omega)-L-arginino)succinate <=> fumarate + L-arginine","pmd":116.011}
{"X":957,"KEGG":"R01087","RHEA_ID":13172,"DIRECTION":"BI","MASTER_ID":13169,"compounds":"maleate <=> fumarate","pmd":0}
{"X":958,"KEGG":"R01088","RHEA_ID":12223,"DIRECTION":"BI","MASTER_ID":12220,"metacyc":"LEUCINE-DEHYDROGENASE-RXN","compounds":"H2O + L-leucine + NAD(+) <=> 4-methyl-2-oxopentanoate + H(+) + NADH + NH4(+)","pmd":534.054}
{"X":959,"KEGG":"R01088","RHEA_ID":12223,"DIRECTION":"BI","MASTER_ID":12220,"metacyc":"LEUCINE-DEHYDROGENASE-RXN","compounds":"H2O + L-leucine + NAD(+) <=> 4-methyl-2-oxopentanoate + H(+) + NADH + NH4(+)","pmd":1.032}
{"X":960,"KEGG":"R01089","RHEA_ID":20092,"DIRECTION":"BI","MASTER_ID":20089,"compounds":"acetyl-CoA + L-leucine <=> CoA + H(+) + N-acetyl-L-leucine","pmd":42.011}
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{"X":962,"KEGG":"R01091","RHEA_ID":10287,"DIRECTION":"BI","MASTER_ID":10284,"metacyc":"LEUCINE-23-AMINOMUTASE-RXN","compounds":"L-leucine <=> (3R)-beta-leucine","pmd":0}
{"X":963,"KEGG":"R01092","RHEA_ID":13556,"DIRECTION":"BI","MASTER_ID":13553,"metacyc":"GALACTOKIN-RXN","compounds":"alpha-D-galactose + ATP <=> ADP + alpha-D-galactose 1-phosphate + H(+)","pmd":79.966}
{"X":964,"KEGG":"R01093","RHEA_ID":37966,"DIRECTION":"BI","MASTER_ID":37963,"metacyc":"RXN-12078","compounds":"galactitol + NAD(+) <=> D-galactose + H(+) + NADH","pmd":2.016}
{"X":965,"KEGG":"R01093","RHEA_ID":37966,"DIRECTION":"BI","MASTER_ID":37963,"metacyc":"RXN-12078","compounds":"galactitol + NAD(+) <=> D-galactose + H(+) + NADH","pmd":483.046}
{"X":966,"KEGG":"R01094","RHEA_ID":21299,"DIRECTION":"BI","MASTER_ID":21296,"compounds":"D-galactose + NAD(+) <=> D-galactono-1,4-lactone + H(+) + NADH","pmd":486.069}
{"X":967,"KEGG":"R01094","RHEA_ID":21299,"DIRECTION":"BI","MASTER_ID":21296,"compounds":"D-galactose + NAD(+) <=> D-galactono-1,4-lactone + H(+) + NADH","pmd":2.016}
{"X":968,"KEGG":"R01095","RHEA_ID":37970,"DIRECTION":"BI","MASTER_ID":37967,"metacyc":"RXN-12078","compounds":"galactitol + NADP(+) <=> D-galactose + H(+) + NADPH","pmd":2.016}
{"X":969,"KEGG":"R01095","RHEA_ID":37970,"DIRECTION":"BI","MASTER_ID":37967,"metacyc":"RXN-12078","compounds":"galactitol + NADP(+) <=> D-galactose + H(+) + NADPH","pmd":563.012}
{"X":970,"KEGG":"R01099","RHEA_ID":24163,"DIRECTION":"BI","MASTER_ID":24160,"compounds":"D-galactose + O2 <=> D-galacto-hexodialdose + H2O2","pmd":2.016}
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{"X":973,"KEGG":"R01101","RHEA_ID":28666,"DIRECTION":"BI","MASTER_ID":28663,"ecocyc":"ALPHAGALACTOSID-RXN","metacyc":"ALPHAGALACTOSID-RXN","compounds":"H2O + melibiose <=> alpha-D-galactose + beta-D-glucose","pmd":162.053}
{"X":974,"KEGG":"R01108","RHEA_ID":24427,"DIRECTION":"BI","MASTER_ID":24424,"compounds":"2 glutathione + L-dehydroascorbate <=> glutathione disulfide + L-ascorbate","pmd":131.052}
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{"X":978,"KEGG":"R01110","RHEA_ID":11467,"DIRECTION":"BI","MASTER_ID":11464,"compounds":"2 glutathione + L,L-homocystine <=> glutathione disulfide + 2 L-homocysteine","pmd":172.048}
{"X":979,"KEGG":"R01110","RHEA_ID":11467,"DIRECTION":"BI","MASTER_ID":11464,"compounds":"2 glutathione + L,L-homocystine <=> glutathione disulfide + 2 L-homocysteine","pmd":133.02}
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{"X":981,"KEGG":"R01111","RHEA_ID":13128,"DIRECTION":"BI","MASTER_ID":13125,"compounds":"CoA + glutathione disulfide <=> CoA-glutathione + glutathione","pmd":460.031}
{"X":982,"KEGG":"R01115","RHEA_ID":16148,"DIRECTION":"BI","MASTER_ID":16145,"compounds":"2 [Fe(II)-cytochrome b5] + CMP-N-acetyl-beta-neuraminate + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + CMP-N-glycoloyl-beta-neuraminate + H2O","pmd":15.995}
{"X":983,"KEGG":"R01121","RHEA_ID":23735,"DIRECTION":"BI","MASTER_ID":23732,"compounds":"(R)-5-diphosphomevalonate + ATP <=> ADP + CO2 + isopentenyl diphosphate + phosphate","pmd":62}
{"X":984,"KEGG":"R01121","RHEA_ID":23735,"DIRECTION":"BI","MASTER_ID":23732,"compounds":"(R)-5-diphosphomevalonate + ATP <=> ADP + CO2 + isopentenyl diphosphate + phosphate","pmd":79.966}
{"X":985,"KEGG":"R01122","RHEA_ID":26485,"DIRECTION":"BI","MASTER_ID":26482,"ecocyc":"RXN0-6274","metacyc":"RXN0-6274","compounds":"adenosine(37) in tRNA + dimethylallyl diphosphate <=> diphosphate + N(6)-dimethylallyladenosine(37) in tRNA"}
{"X":986,"KEGG":"R01123","RHEA_ID":23287,"DIRECTION":"BI","MASTER_ID":23284,"ecocyc":"IPPISOM-RXN","metacyc":"IPPISOM-RXN","compounds":"isopentenyl diphosphate <=> dimethylallyl diphosphate","pmd":0}
{"X":987,"KEGG":"R01126","RHEA_ID":27721,"DIRECTION":"BI","MASTER_ID":27718,"compounds":"H2O + IMP <=> inosine + phosphate","pmd":79.966}
{"X":988,"KEGG":"R01127","RHEA_ID":18448,"DIRECTION":"BI","MASTER_ID":18445,"ecocyc":"IMPCYCLOHYDROLASE-RXN","metacyc":"IMPCYCLOHYDROLASE-RXN","compounds":"H2O + IMP <=> 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide","pmd":18.011}
{"X":989,"KEGG":"R01128","RHEA_ID":20472,"DIRECTION":"BI","MASTER_ID":20469,"compounds":"H2O + IMP <=> D-ribose 5-phosphate + hypoxanthine","pmd":118.028}
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{"X":992,"KEGG":"R01131","RHEA_ID":21143,"DIRECTION":"BI","MASTER_ID":21140,"compounds":"ATP + inosine <=> ADP + H(+) + IMP","pmd":79.966}
{"X":993,"KEGG":"R01132","RHEA_ID":17976,"DIRECTION":"BI","MASTER_ID":17973,"compounds":"diphosphate + IMP <=> 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine","pmd":41.905}
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{"X":995,"KEGG":"R01134","RHEA_ID":17188,"DIRECTION":"BI","MASTER_ID":17185,"compounds":"IMP + NADP(+) + NH4(+) <=> GMP + 2 H(+) + NADPH","pmd":15.011}
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{"X":997,"KEGG":"R01135","RHEA_ID":15756,"DIRECTION":"BI","MASTER_ID":15753,"compounds":"GTP + IMP + L-aspartate <=> GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate","pmd":94.977}
{"X":998,"KEGG":"R01135","RHEA_ID":15756,"DIRECTION":"BI","MASTER_ID":15753,"compounds":"GTP + IMP + L-aspartate <=> GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate","pmd":59.917}
{"X":999,"KEGG":"R01137","RHEA_ID":27677,"DIRECTION":"BI","MASTER_ID":27674,"compounds":"ATP + dADP <=> ADP + dATP","pmd":15.995}
{"X":1000,"KEGG":"R01138","RHEA_ID":30730,"DIRECTION":"BI","MASTER_ID":30727,"compounds":"dATP + pyruvate <=> dADP + H(+) + phosphoenolpyruvate","pmd":79.966}
{"X":1001,"KEGG":"R01142","RHEA_ID":13640,"DIRECTION":"BI","MASTER_ID":13637,"compounds":"H(+) + methane + NADH + O2 <=> H2O + methanol + NAD(+)"}
{"X":1002,"KEGG":"R01143","RHEA_ID":13644,"DIRECTION":"BI","MASTER_ID":13641,"compounds":"H(+) + methane + NADPH + O2 <=> H2O + methanol + NADP(+)"}
{"X":1003,"KEGG":"R01144","RHEA_ID":10567,"DIRECTION":"BI","MASTER_ID":10564,"compounds":"H2O + oxaloacetate 4-methyl ester <=> H(+) + methanol + oxaloacetate","pmd":14.016}
{"X":1004,"KEGG":"R01145","RHEA_ID":14224,"DIRECTION":"BI","MASTER_ID":14221,"compounds":"H2O + monomethyl sulfate <=> H(+) + methanol + sulfate"}
{"X":1005,"KEGG":"R01146","RHEA_ID":51011,"DIRECTION":"BI","MASTER_ID":51008,"compounds":"2 [Fe(III)cytochrome cL] + methanol <=> 2 [Fe(II)cytochrome cL] + formaldehyde + 2 H(+)"}
{"X":1006,"KEGG":"R01147","RHEA_ID":28565,"DIRECTION":"BI","MASTER_ID":28562,"ecocyc":"RXN0-5240","metacyc":"RXN0-5240","compounds":"D-alanine + pyridoxal 5'-phosphate <=> pyridoxamine 5'-phosphate + pyruvate","pmd":1.032}
{"X":1007,"KEGG":"R01148","RHEA_ID":15872,"DIRECTION":"BI","MASTER_ID":15869,"metacyc":"D-ALANINE-AMINOTRANSFERASE-RXN","compounds":"2-oxoglutarate + D-alanine <=> D-glutamate + pyruvate","pmd":1.032}
{"X":1008,"KEGG":"R01149","RHEA_ID":23559,"DIRECTION":"BI","MASTER_ID":23556,"compounds":"D-alanine + L-glutamine <=> gamma-L-glutamyl-D-alanine + NH4(+)","pmd":72.021}
{"X":1009,"KEGG":"R01150","RHEA_ID":11227,"DIRECTION":"BI","MASTER_ID":11224,"ecocyc":"DALADALALIG-RXN","metacyc":"DALADALALIG-RXN","compounds":"ATP + 2 D-alanine <=> ADP + D-alanyl-D-alanine + H(+) + phosphate","pmd":79.966}
{"X":1010,"KEGG":"R01151","RHEA_ID":18276,"DIRECTION":"BI","MASTER_ID":18273,"compounds":"H2O + O2 + putrescine <=> 4-aminobutanal + H2O2 + NH4(+)"}
{"X":1011,"KEGG":"R01152","RHEA_ID":22287,"DIRECTION":"BI","MASTER_ID":22284,"compounds":"2 H(+) + H2O + N-carbamoylputrescine <=> CO2 + NH4(+) + putrescine"}
{"X":1012,"KEGG":"R01153","RHEA_ID":15040,"DIRECTION":"BI","MASTER_ID":15037,"compounds":"putrescine + S-adenosyl-L-methionine <=> H(+) + N-methylputrescine + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":1013,"KEGG":"R01154","RHEA_ID":25184,"DIRECTION":"BI","MASTER_ID":25181,"compounds":"acetyl-CoA + putrescine <=> CoA + H(+) + N-acetylputrescine","pmd":42.011}
{"X":1014,"KEGG":"R01155","RHEA_ID":23819,"DIRECTION":"BI","MASTER_ID":23816,"compounds":"2-oxoglutarate + putrescine <=> 4-aminobutanal + L-glutamate","pmd":1.032}
{"X":1015,"KEGG":"R01156","RHEA_ID":23415,"DIRECTION":"BI","MASTER_ID":23412,"metacyc":"ACETYLPUTRESCINE-DEACETYLASE-RXN","compounds":"H2O + N-acetylputrescine <=> acetate + putrescine"}
{"X":1016,"KEGG":"R01157","RHEA_ID":13932,"DIRECTION":"BI","MASTER_ID":13929,"metacyc":"AGMATIN-RXN","compounds":"agmatine + H2O <=> putrescine + urea"}
{"X":1017,"KEGG":"R01158","RHEA_ID":20644,"DIRECTION":"BI","MASTER_ID":20641,"metacyc":"RXN-8001","compounds":"H2O + L-histidinol + 2 NAD(+) <=> 3 H(+) + L-histidine + 2 NADH","pmd":509.047}
{"X":1018,"KEGG":"R01158","RHEA_ID":20644,"DIRECTION":"BI","MASTER_ID":20641,"metacyc":"RXN-8001","compounds":"H2O + L-histidinol + 2 NAD(+) <=> 3 H(+) + L-histidine + 2 NADH","pmd":13.979}
{"X":1019,"KEGG":"R01160","RHEA_ID":24599,"DIRECTION":"BI","MASTER_ID":24596,"metacyc":"HISTIDINE-N-ACETYLTRANSFERASE-RXN","compounds":"acetyl-CoA + L-histidine <=> CoA + H(+) + N(alpha)-acetyl-L-histidine","pmd":42.011}
{"X":1020,"KEGG":"R01161","RHEA_ID":16568,"DIRECTION":"BI","MASTER_ID":16565,"metacyc":"HISTTRANSAM-RXN","compounds":"2-oxoglutarate + L-histidine <=> 3-(imidazol-5-yl)pyruvate + L-glutamate","pmd":1.032}
{"X":1021,"KEGG":"R01163","RHEA_ID":33806,"DIRECTION":"BI","MASTER_ID":33803,"compounds":"H2O + L-histidinal + NAD(+) <=> 2 H(+) + L-histidine + NADH","pmd":509.047}
{"X":1022,"KEGG":"R01163","RHEA_ID":33806,"DIRECTION":"BI","MASTER_ID":33803,"compounds":"H2O + L-histidinal + NAD(+) <=> 2 H(+) + L-histidine + NADH","pmd":15.995}
{"X":1023,"KEGG":"R01164","RHEA_ID":19300,"DIRECTION":"BI","MASTER_ID":19297,"compounds":"ATP + beta-alanine + L-histidine <=> ADP + carnosine + H(+) + phosphate","pmd":79.966}
{"X":1024,"KEGG":"R01164","RHEA_ID":19300,"DIRECTION":"BI","MASTER_ID":19297,"compounds":"ATP + beta-alanine + L-histidine <=> ADP + carnosine + H(+) + phosphate","pmd":71.037}
{"X":1025,"KEGG":"R01166","RHEA_ID":59363,"DIRECTION":"BI","MASTER_ID":59360,"compounds":"carnosine + H2O <=> beta-alanine + L-histidine","pmd":71.037}
{"X":1026,"KEGG":"R01167","RHEA_ID":20843,"DIRECTION":"BI","MASTER_ID":20840,"compounds":"H(+) + L-histidine <=> CO2 + histamine","pmd":43.99}
{"X":1027,"KEGG":"R01168","RHEA_ID":21235,"DIRECTION":"BI","MASTER_ID":21232,"compounds":"L-histidine <=> NH4(+) + trans-urocanate","pmd":17.027}
{"X":1028,"KEGG":"R01169","RHEA_ID":38474,"DIRECTION":"BI","MASTER_ID":38471,"compounds":"L-histidine + 3 S-adenosyl-L-methionine <=> 3 H(+) + hercynine + 3 S-adenosyl-L-homocysteine","pmd":14.016}
{"X":1029,"KEGG":"R01169","RHEA_ID":38474,"DIRECTION":"BI","MASTER_ID":38471,"compounds":"L-histidine + 3 S-adenosyl-L-methionine <=> 3 H(+) + hercynine + 3 S-adenosyl-L-homocysteine","pmd":43.055}
{"X":1030,"KEGG":"R01171","RHEA_ID":52575,"DIRECTION":"BI","MASTER_ID":52572,"compounds":"butanoyl-CoA + NAD(+) <=> (2E)-butenoyl-CoA + H(+) + NADH","pmd":2.016}
{"X":1031,"KEGG":"R01171","RHEA_ID":52575,"DIRECTION":"BI","MASTER_ID":52572,"compounds":"butanoyl-CoA + NAD(+) <=> (2E)-butenoyl-CoA + H(+) + NADH","pmd":171.024}
{"X":1032,"KEGG":"R01172","RHEA_ID":22971,"DIRECTION":"BI","MASTER_ID":22968,"metacyc":"BUTANAL-DEHYDROGENASE-RXN","compounds":"butanal + CoA + NAD(+) <=> butanoyl-CoA + H(+) + NADH","pmd":173.04}
{"X":1033,"KEGG":"R01172","RHEA_ID":22971,"DIRECTION":"BI","MASTER_ID":22968,"metacyc":"BUTANAL-DEHYDROGENASE-RXN","compounds":"butanal + CoA + NAD(+) <=> butanoyl-CoA + H(+) + NADH","pmd":70.042}
{"X":1034,"KEGG":"R01173","RHEA_ID":22975,"DIRECTION":"BI","MASTER_ID":22972,"metacyc":"BUTANAL-DEHYDROGENASE-RXN","compounds":"butanal + CoA + NADP(+) <=> butanoyl-CoA + H(+) + NADPH","pmd":93.074}
{"X":1035,"KEGG":"R01173","RHEA_ID":22975,"DIRECTION":"BI","MASTER_ID":22972,"metacyc":"BUTANAL-DEHYDROGENASE-RXN","compounds":"butanal + CoA + NADP(+) <=> butanoyl-CoA + H(+) + NADPH","pmd":22.024}
{"X":1036,"KEGG":"R01174","RHEA_ID":20895,"DIRECTION":"BI","MASTER_ID":20892,"metacyc":"PHOSPHATE-BUTYRYLTRANSFERASE-RXN","compounds":"butanoyl-CoA + phosphate <=> butanoyl phosphate + CoA","pmd":70.042}
{"X":1037,"KEGG":"R01175","RHEA_ID":30734,"DIRECTION":"BI","MASTER_ID":30731,"compounds":"butanoyl-CoA + FAD + H(+) <=> (2E)-butenoyl-CoA + FADH2","pmd":2.016}
{"X":1038,"KEGG":"R01175","RHEA_ID":24007,"DIRECTION":"BI","MASTER_ID":24004,"compounds":"butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]","pmd":2.016}
{"X":1039,"KEGG":"R01177","RHEA_ID":31114,"DIRECTION":"BI","MASTER_ID":31111,"compounds":"acetyl-CoA + butanoyl-CoA <=> 3-oxohexanoyl-CoA + CoA","pmd":42.011}
{"X":1040,"KEGG":"R01177","RHEA_ID":31114,"DIRECTION":"BI","MASTER_ID":31111,"compounds":"acetyl-CoA + butanoyl-CoA <=> 3-oxohexanoyl-CoA + CoA","pmd":42.01}
{"X":1041,"KEGG":"R01178","RHEA_ID":25167,"DIRECTION":"BI","MASTER_ID":25164,"compounds":"A + butanoyl-CoA <=> (2E)-butenoyl-CoA + AH2"}
{"X":1042,"KEGG":"R01178","RHEA_ID":47199,"DIRECTION":"BI","MASTER_ID":47196,"compounds":"a short-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":1043,"KEGG":"R01179","RHEA_ID":30074,"DIRECTION":"BI","MASTER_ID":30071,"metacyc":"R11-RXN","compounds":"acetyl-CoA + butanoate <=> acetate + butanoyl-CoA","pmd":28.031}
{"X":1044,"KEGG":"R01180","RHEA_ID":10503,"DIRECTION":"BI","MASTER_ID":10500,"metacyc":"3-ETHYLMALATE-SYNTHASE-RXN","compounds":"butanoyl-CoA + glyoxylate + H2O <=> 3-ethylmalate + CoA + H(+)","pmd":675.104}
{"X":1045,"KEGG":"R01180","RHEA_ID":10503,"DIRECTION":"BI","MASTER_ID":10500,"metacyc":"3-ETHYLMALATE-SYNTHASE-RXN","compounds":"butanoyl-CoA + glyoxylate + H2O <=> 3-ethylmalate + CoA + H(+)","pmd":70.042}
{"X":1046,"KEGG":"R01181","RHEA_ID":13144,"DIRECTION":"BI","MASTER_ID":13141,"metacyc":"ISOBUTYRYL-COA-MUTASE-RXN","compounds":"2-methylpropanoyl-CoA <=> butanoyl-CoA","pmd":0}
{"X":1047,"KEGG":"R01183","RHEA_ID":16952,"DIRECTION":"BI","MASTER_ID":16949,"metacyc":"MYO-INOSITOL-2-DEHYDROGENASE-RXN","compounds":"myo-inositol + NAD(+) <=> H(+) + NADH + scyllo-inosose","pmd":486.069}
{"X":1048,"KEGG":"R01183","RHEA_ID":16952,"DIRECTION":"BI","MASTER_ID":16949,"metacyc":"MYO-INOSITOL-2-DEHYDROGENASE-RXN","compounds":"myo-inositol + NAD(+) <=> H(+) + NADH + scyllo-inosose","pmd":2.016}
{"X":1049,"KEGG":"R01184","RHEA_ID":23699,"DIRECTION":"BI","MASTER_ID":23696,"compounds":"myo-inositol + O2 <=> D-glucuronate + H(+) + H2O","pmd":13.979}
{"X":1050,"KEGG":"R01185","RHEA_ID":27673,"DIRECTION":"BI","MASTER_ID":27670,"compounds":"1D-myo-inositol 1-phosphate + H2O <=> myo-inositol + phosphate","pmd":79.966}
{"X":1051,"KEGG":"R01186","RHEA_ID":30738,"DIRECTION":"BI","MASTER_ID":30735,"compounds":"1D-myo-inositol 4-phosphate + H2O <=> myo-inositol + phosphate","pmd":79.966}
{"X":1052,"KEGG":"R01187","RHEA_ID":30742,"DIRECTION":"BI","MASTER_ID":30739,"compounds":"1D-myo-inositol 3-phosphate + H2O <=> myo-inositol + phosphate","pmd":79.966}
{"X":1053,"KEGG":"R01188","RHEA_ID":17568,"DIRECTION":"BI","MASTER_ID":17565,"compounds":"myo-inositol + S-adenosyl-L-methionine <=> 1D-1-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":1054,"KEGG":"R01189","RHEA_ID":18880,"DIRECTION":"BI","MASTER_ID":18877,"compounds":"myo-inositol + S-adenosyl-L-methionine <=> 1D-3-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":1055,"KEGG":"R01190","RHEA_ID":23251,"DIRECTION":"BI","MASTER_ID":23248,"compounds":"myo-inositol + S-adenosyl-L-methionine <=> 1D-4-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":1056,"KEGG":"R01192","RHEA_ID":12467,"DIRECTION":"BI","MASTER_ID":12464,"compounds":"myo-inositol + UDP-alpha-D-galactose <=> alpha-D-galactosyl-(1->3)-1D-myo-inositol + H(+) + UDP","pmd":162.053}
{"X":1057,"KEGG":"R01193","RHEA_ID":16504,"DIRECTION":"BI","MASTER_ID":16501,"compounds":"H2O + sn-glycero-3-phospho-1D-myo-inositol <=> H(+) + myo-inositol + sn-glycerol 3-phosphate","pmd":154.003}
{"X":1058,"KEGG":"R01195","RHEA_ID":20128,"DIRECTION":"BI","MASTER_ID":20125,"metacyc":"RXN-14040","compounds":"H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":1059,"KEGG":"R01196","RHEA_ID":12768,"DIRECTION":"BI","MASTER_ID":12765,"ecocyc":"PYRUFLAVREDUCT-RXN","metacyc":"PYRUFLAVREDUCT-RXN","compounds":"CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate <=> acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]","pmd":42.011}
{"X":1060,"KEGG":"R01196","RHEA_ID":44143,"DIRECTION":"BI","MASTER_ID":44140,"ecocyc":"PYFLAVOXRE-RXN","metacyc":"PYFLAVOXRE-RXN","compounds":"CoA + 2 H(+) + oxidized [flavodoxin] + pyruvate <=> acetyl-CoA + CO2 + reduced [flavodoxin]","pmd":42.011}
{"X":1061,"KEGG":"R01197","RHEA_ID":17300,"DIRECTION":"BI","MASTER_ID":17297,"metacyc":"2-OXOGLUTARATE-SYNTHASE-RXN","compounds":"2-oxoglutarate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] <=> CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] + succinyl-CoA","pmd":100.016}
{"X":1062,"KEGG":"R01199","RHEA_ID":32138,"DIRECTION":"BI","MASTER_ID":32135,"metacyc":"2-OXOBUTYRATE-SYNTHASE-RXN","compounds":"2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] <=> CO2 + H(+) + propanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin]","pmd":56.026}
{"X":1063,"KEGG":"R01199","RHEA_ID":32138,"DIRECTION":"BI","MASTER_ID":32135,"metacyc":"2-OXOBUTYRATE-SYNTHASE-RXN","compounds":"2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] <=> CO2 + H(+) + propanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin]","pmd":721.11}
{"X":1064,"KEGG":"R01200","RHEA_ID":20596,"DIRECTION":"BI","MASTER_ID":20593,"metacyc":"N-ACETYLGLUCOSAMINE-DEACETYLASE-RXN","compounds":"H2O + N-acetyl-D-glucosamine <=> acetate + D-glucosamine","pmd":42.011}
{"X":1065,"KEGG":"R01201","RHEA_ID":17420,"DIRECTION":"BI","MASTER_ID":17417,"compounds":"ATP + N-acetyl-D-glucosamine <=> ADP + H(+) + N-acetyl-D-glucosamine 6-phosphate","pmd":79.966}
{"X":1066,"KEGG":"R01202","RHEA_ID":23147,"DIRECTION":"BI","MASTER_ID":23144,"compounds":"H2O + N-acetyl-alpha-D-glucosamine + NAD(+) <=> 2 H(+) + N-acetyl-D-glucosaminate + NADH","pmd":427.032}
{"X":1067,"KEGG":"R01202","RHEA_ID":23147,"DIRECTION":"BI","MASTER_ID":23144,"compounds":"H2O + N-acetyl-alpha-D-glucosamine + NAD(+) <=> 2 H(+) + N-acetyl-D-glucosaminate + NADH","pmd":15.995}
{"X":1068,"KEGG":"R01203","RHEA_ID":13032,"DIRECTION":"BI","MASTER_ID":13029,"compounds":"H2O + N-acetyl-D-glucosamine + O2 <=> H(+) + H2O2 + N-acetyl-D-glucosaminate","pmd":15.995}
{"X":1069,"KEGG":"R01204","RHEA_ID":21335,"DIRECTION":"BI","MASTER_ID":21332,"compounds":"acetyl-CoA + D-glucosamine <=> CoA + H(+) + N-acetyl-D-glucosamine","pmd":42.011}
{"X":1070,"KEGG":"R01205","RHEA_ID":17748,"DIRECTION":"BI","MASTER_ID":17745,"metacyc":"N-ACETYLLACTOSAMINE-SYNTHASE-RXN","compounds":"N-acetyl-D-glucosamine + UDP-alpha-D-galactose <=> beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + H(+) + UDP","pmd":162.053}
{"X":1071,"KEGG":"R01209","RHEA_ID":20939,"DIRECTION":"BI","MASTER_ID":20936,"compounds":"2,3-dihydroxy-3-methylbutanoate <=> 3-methyl-2-oxobutanoate + H2O","pmd":18.011}
{"X":1072,"KEGG":"R01210","RHEA_ID":14000,"DIRECTION":"BI","MASTER_ID":13997,"compounds":"3-methyl-2-oxobutanoate + CoA + NAD(+) <=> 2-methylpropanoyl-CoA + CO2 + NADH","pmd":70.042}
{"X":1073,"KEGG":"R01210","RHEA_ID":14000,"DIRECTION":"BI","MASTER_ID":13997,"compounds":"3-methyl-2-oxobutanoate + CoA + NAD(+) <=> 2-methylpropanoyl-CoA + CO2 + NADH","pmd":173.04}
{"X":1074,"KEGG":"R01210","RHEA_ID":14000,"DIRECTION":"BI","MASTER_ID":13997,"compounds":"3-methyl-2-oxobutanoate + CoA + NAD(+) <=> 2-methylpropanoyl-CoA + CO2 + NADH","pmd":549.078}
{"X":1075,"KEGG":"R01211","RHEA_ID":13324,"DIRECTION":"BI","MASTER_ID":13321,"compounds":"(R)-3,3-dimethylmalate + NAD(+) <=> 3-methyl-2-oxobutanoate + CO2 + NADH","pmd":46.005}
{"X":1076,"KEGG":"R01211","RHEA_ID":13324,"DIRECTION":"BI","MASTER_ID":13321,"compounds":"(R)-3,3-dimethylmalate + NAD(+) <=> 3-methyl-2-oxobutanoate + CO2 + NADH","pmd":548.07}
{"X":1077,"KEGG":"R01212","RHEA_ID":11159,"DIRECTION":"BI","MASTER_ID":11156,"compounds":"H2O + L-valine + NADP(+) <=> 3-methyl-2-oxobutanoate + H(+) + NADPH + NH4(+)","pmd":628.036}
{"X":1078,"KEGG":"R01212","RHEA_ID":11159,"DIRECTION":"BI","MASTER_ID":11156,"compounds":"H2O + L-valine + NADP(+) <=> 3-methyl-2-oxobutanoate + H(+) + NADPH + NH4(+)","pmd":1.032}
{"X":1079,"KEGG":"R01213","RHEA_ID":21527,"DIRECTION":"BI","MASTER_ID":21524,"compounds":"3-methyl-2-oxobutanoate + acetyl-CoA + H2O <=> (2S)-2-isopropylmalate + CoA + H(+)","pmd":60.021}
{"X":1080,"KEGG":"R01213","RHEA_ID":21527,"DIRECTION":"BI","MASTER_ID":21524,"compounds":"3-methyl-2-oxobutanoate + acetyl-CoA + H2O <=> (2S)-2-isopropylmalate + CoA + H(+)","pmd":42.011}
{"X":1081,"KEGG":"R01214","RHEA_ID":24816,"DIRECTION":"BI","MASTER_ID":24813,"ecocyc":"BRANCHED-CHAINAMINOTRANSFERVAL-RXN","metacyc":"BRANCHED-CHAINAMINOTRANSFERVAL-RXN","compounds":"2-oxoglutarate + L-valine <=> 3-methyl-2-oxobutanoate + L-glutamate","pmd":1.032}
{"X":1082,"KEGG":"R01215","RHEA_ID":22915,"DIRECTION":"BI","MASTER_ID":22912,"ecocyc":"VALINE-PYRUVATE-AMINOTRANSFER-RXN","metacyc":"VALINE-PYRUVATE-AMINOTRANSFER-RXN","compounds":"L-valine + pyruvate <=> 3-methyl-2-oxobutanoate + L-alanine","pmd":1.032}
{"X":1083,"KEGG":"R01216","RHEA_ID":23279,"DIRECTION":"BI","MASTER_ID":23276,"compounds":"2-dehydropantoate <=> 3-methyl-2-oxobutanoate + formaldehyde","pmd":30.011}
{"X":1084,"KEGG":"R01217","RHEA_ID":14232,"DIRECTION":"BI","MASTER_ID":14229,"compounds":"(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 2 oxidized [2Fe-2S]-[ferredoxin] <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]","pmd":2.016}
{"X":1085,"KEGG":"R01218","RHEA_ID":22895,"DIRECTION":"BI","MASTER_ID":22892,"compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NAD(+) <=> 5,10-methenyltetrahydrofolate + NADH","pmd":207.954}
{"X":1086,"KEGG":"R01220","RHEA_ID":22815,"DIRECTION":"BI","MASTER_ID":22812,"ecocyc":"METHYLENETHFDEHYDROG-NADP-RXN","metacyc":"METHYLENETHFDEHYDROG-NADP-RXN","compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) <=> 5,10-methenyltetrahydrofolate + NADPH","pmd":287.92}
{"X":1087,"KEGG":"R01221","RHEA_ID":27761,"DIRECTION":"BI","MASTER_ID":27758,"metacyc":"GCVMULTI-RXN","compounds":"(6S)-5,6,7,8-tetrahydrofolate + glycine + NAD(+) <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + CO2 + NADH + NH4(+)","pmd":206.946}
{"X":1088,"KEGG":"R01221","RHEA_ID":27761,"DIRECTION":"BI","MASTER_ID":27758,"metacyc":"GCVMULTI-RXN","compounds":"(6S)-5,6,7,8-tetrahydrofolate + glycine + NAD(+) <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + CO2 + NADH + NH4(+)","pmd":12}
{"X":1089,"KEGG":"R01224","RHEA_ID":19820,"DIRECTION":"BI","MASTER_ID":19817,"compounds":"(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH","pmd":2.016}
{"X":1090,"KEGG":"R01224","RHEA_ID":19820,"DIRECTION":"BI","MASTER_ID":19817,"compounds":"(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH","pmd":286.912}
{"X":1091,"KEGG":"R01225","RHEA_ID":10067,"DIRECTION":"BI","MASTER_ID":10064,"compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + D-alanine + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + 2-methylserine","pmd":12}
{"X":1092,"KEGG":"R01226","RHEA_ID":11827,"DIRECTION":"BI","MASTER_ID":11824,"ecocyc":"3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-RXN","metacyc":"3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-RXN","compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate","pmd":30.011}
{"X":1093,"KEGG":"R01226","RHEA_ID":11827,"DIRECTION":"BI","MASTER_ID":11824,"ecocyc":"3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-RXN","metacyc":"3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-RXN","compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate","pmd":12}
{"X":1094,"KEGG":"R01227","RHEA_ID":27717,"DIRECTION":"BI","MASTER_ID":27714,"compounds":"GMP + H2O <=> guanosine + phosphate","pmd":79.966}
{"X":1095,"KEGG":"R01228","RHEA_ID":27713,"DIRECTION":"BI","MASTER_ID":27710,"compounds":"ATP + guanosine <=> ADP + GMP + H(+)","pmd":79.966}
{"X":1096,"KEGG":"R01229","RHEA_ID":25427,"DIRECTION":"BI","MASTER_ID":25424,"metacyc":"GUANPRIBOSYLTRAN-RXN","compounds":"diphosphate + GMP <=> 5-phospho-alpha-D-ribose 1-diphosphate + guanine","pmd":26.894}
{"X":1097,"KEGG":"R01230","RHEA_ID":18304,"DIRECTION":"BI","MASTER_ID":18301,"compounds":"ATP + NH4(+) + XMP <=> AMP + diphosphate + GMP + 2 H(+)","pmd":143.938}
{"X":1098,"KEGG":"R01230","RHEA_ID":18304,"DIRECTION":"BI","MASTER_ID":18301,"compounds":"ATP + NH4(+) + XMP <=> AMP + diphosphate + GMP + 2 H(+)","pmd":0.984}
{"X":1099,"KEGG":"R01231","RHEA_ID":11683,"DIRECTION":"BI","MASTER_ID":11680,"compounds":"ATP + H2O + L-glutamine + XMP <=> AMP + diphosphate + GMP + 2 H(+) + L-glutamate","pmd":143.938}
{"X":1100,"KEGG":"R01231","RHEA_ID":11683,"DIRECTION":"BI","MASTER_ID":11680,"compounds":"ATP + H2O + L-glutamine + XMP <=> AMP + diphosphate + GMP + 2 H(+) + L-glutamate","pmd":0.984}
{"X":1101,"KEGG":"R01232","RHEA_ID":22487,"DIRECTION":"BI","MASTER_ID":22484,"metacyc":"3.6.1.17-RXN","compounds":"H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate <=> GMP + GTP + 2 H(+)","pmd":345.047}
{"X":1102,"KEGG":"R01233","RHEA_ID":62179,"DIRECTION":"BI","MASTER_ID":62176,"compounds":"GDP-alpha-D-glucose + H2O <=> alpha-D-glucose 1-phosphate + GMP + 2 H(+)","pmd":242.019}
{"X":1103,"KEGG":"R01234","RHEA_ID":16960,"DIRECTION":"BI","MASTER_ID":16957,"compounds":"3',5'-cyclic GMP + H2O <=> GMP + H(+)","pmd":18.011}
{"X":1104,"KEGG":"R01235","RHEA_ID":18280,"DIRECTION":"BI","MASTER_ID":18277,"compounds":"a thiol + S-adenosyl-L-methionine <=> a methyl thioether + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":1105,"KEGG":"R01236","RHEA_ID":14640,"DIRECTION":"BI","MASTER_ID":14637,"compounds":"3'-phosphoadenylyl sulfate + a thiol <=> adenosine 3',5'-bisphosphate + H(+) + S-alkyl thiosulfate","pmd":79.957}
{"X":1106,"KEGG":"R01238","RHEA_ID":10879,"DIRECTION":"BI","MASTER_ID":10876,"metacyc":"4-HYDROXYBENZOATE-DECARBOXYLASE-RXN","compounds":"4-hydroxybenzoate + H(+) <=> CO2 + phenol"}
{"X":1107,"KEGG":"R01242","RHEA_ID":12167,"DIRECTION":"BI","MASTER_ID":12164,"compounds":"3'-phosphoadenylyl sulfate + a phenol <=> a phenyl sulfate + adenosine 3',5'-bisphosphate + H(+)","pmd":79.957}
{"X":1108,"KEGG":"R01243","RHEA_ID":17264,"DIRECTION":"BI","MASTER_ID":17261,"compounds":"a phenyl sulfate + H2O <=> a phenol + H(+) + sulfate"}
{"X":1109,"KEGG":"R01244","RHEA_ID":23691,"DIRECTION":"BI","MASTER_ID":23688,"compounds":"adenine + H(+) + H2O <=> hypoxanthine + NH4(+)","pmd":0.984}
{"X":1110,"KEGG":"R01245","RHEA_ID":18672,"DIRECTION":"BI","MASTER_ID":18669,"compounds":"adenosine + H2O <=> adenine + D-ribose","pmd":117.044}
{"X":1111,"KEGG":"R01246","RHEA_ID":20324,"DIRECTION":"BI","MASTER_ID":20321,"compounds":"L-proline + NAD(+) <=> 1-pyrroline-2-carboxylate + H(+) + NADH","pmd":2.016}
{"X":1112,"KEGG":"R01246","RHEA_ID":20324,"DIRECTION":"BI","MASTER_ID":20321,"compounds":"L-proline + NAD(+) <=> 1-pyrroline-2-carboxylate + H(+) + NADH","pmd":551.069}
{"X":1113,"KEGG":"R01248","RHEA_ID":14108,"DIRECTION":"BI","MASTER_ID":14105,"compounds":"L-proline + NAD(+) <=> 1-pyrroline-5-carboxylate + 2 H(+) + NADH","pmd":551.069}
{"X":1114,"KEGG":"R01248","RHEA_ID":14108,"DIRECTION":"BI","MASTER_ID":14105,"compounds":"L-proline + NAD(+) <=> 1-pyrroline-5-carboxylate + 2 H(+) + NADH","pmd":2.016}
{"X":1115,"KEGG":"R01249","RHEA_ID":20320,"DIRECTION":"BI","MASTER_ID":20317,"metacyc":"RXN-16268","compounds":"L-proline + NADP(+) <=> 1-pyrroline-2-carboxylate + H(+) + NADPH","pmd":631.036}
{"X":1116,"KEGG":"R01249","RHEA_ID":20320,"DIRECTION":"BI","MASTER_ID":20317,"metacyc":"RXN-16268","compounds":"L-proline + NADP(+) <=> 1-pyrroline-2-carboxylate + H(+) + NADPH","pmd":2.016}
{"X":1117,"KEGG":"R01251","RHEA_ID":14112,"DIRECTION":"BI","MASTER_ID":14109,"compounds":"L-proline + NADP(+) <=> 1-pyrroline-5-carboxylate + 2 H(+) + NADPH","pmd":631.036}
{"X":1118,"KEGG":"R01251","RHEA_ID":14112,"DIRECTION":"BI","MASTER_ID":14109,"compounds":"L-proline + NADP(+) <=> 1-pyrroline-5-carboxylate + 2 H(+) + NADPH","pmd":2.016}
{"X":1119,"KEGG":"R01252","RHEA_ID":51511,"DIRECTION":"BI","MASTER_ID":51508,"compounds":"2-oxoglutarate + L-proline + O2 <=> CO2 + succinate + trans-4-hydroxy-L-proline","pmd":2.963}
{"X":1120,"KEGG":"R01252","RHEA_ID":51511,"DIRECTION":"BI","MASTER_ID":51508,"compounds":"2-oxoglutarate + L-proline + O2 <=> CO2 + succinate + trans-4-hydroxy-L-proline","pmd":14.963}
{"X":1121,"KEGG":"R01253","RHEA_ID":23787,"DIRECTION":"BI","MASTER_ID":23784,"compounds":"a quinone + L-proline <=> (S)-1-pyrroline-5-carboxylate + a quinol + H(+)","pmd":2.016}
{"X":1122,"KEGG":"R01255","RHEA_ID":10683,"DIRECTION":"BI","MASTER_ID":10680,"metacyc":"PROLINE-RACEMASE-RXN","compounds":"L-proline <=> D-proline","pmd":0}
{"X":1123,"KEGG":"R01256","RHEA_ID":26196,"DIRECTION":"BI","MASTER_ID":26193,"metacyc":"MALATE--COA-LIGASE-RXN","compounds":"(S)-malate + ATP + CoA <=> (S)-malyl-CoA + ADP + phosphate","pmd":293.008}
{"X":1124,"KEGG":"R01256","RHEA_ID":26196,"DIRECTION":"BI","MASTER_ID":26193,"metacyc":"MALATE--COA-LIGASE-RXN","compounds":"(S)-malate + ATP + CoA <=> (S)-malyl-CoA + ADP + phosphate","pmd":79.966}
{"X":1125,"KEGG":"R01256","RHEA_ID":26196,"DIRECTION":"BI","MASTER_ID":26193,"metacyc":"MALATE--COA-LIGASE-RXN","compounds":"(S)-malate + ATP + CoA <=> (S)-malyl-CoA + ADP + phosphate","pmd":116.011}
{"X":1126,"KEGG":"R01257","RHEA_ID":31294,"DIRECTION":"BI","MASTER_ID":31291,"compounds":"(S)-malate + FAD + H(+) <=> FADH2 + oxaloacetate","pmd":2.016}
{"X":1127,"KEGG":"R01258","RHEA_ID":10399,"DIRECTION":"BI","MASTER_ID":10396,"compounds":"an L-alpha-amino acid + H2O + NAD(+) <=> a 2-oxocarboxylate + H(+) + NADH + NH4(+)"}
{"X":1128,"KEGG":"R01259","RHEA_ID":13784,"DIRECTION":"BI","MASTER_ID":13781,"compounds":"an L-alpha-amino acid + H2O + O2 <=> a 2-oxocarboxylate + H2O2 + NH4(+)"}
{"X":1129,"KEGG":"R01261","RHEA_ID":19956,"DIRECTION":"BI","MASTER_ID":19953,"metacyc":"ALANINE--OXO-ACID-AMINOTRANSFERASE-RXN","compounds":"a 2-oxocarboxylate + L-alanine <=> an L-alpha-amino acid + pyruvate"}
{"X":1130,"KEGG":"R01263","RHEA_ID":15568,"DIRECTION":"BI","MASTER_ID":15565,"compounds":"an N-acyl-L-amino acid + H2O <=> a carboxylate + an L-alpha-amino acid"}
{"X":1131,"KEGG":"R01264","RHEA_ID":11475,"DIRECTION":"BI","MASTER_ID":11472,"compounds":"an N-methyl-L-amino acid + H2O + O2 <=> an L-alpha-amino acid + formaldehyde + H2O2"}
{"X":1132,"KEGG":"R01265","RHEA_ID":18320,"DIRECTION":"BI","MASTER_ID":18317,"compounds":"an L-alpha-amino acid <=> a D-alpha-amino acid"}
{"X":1133,"KEGG":"R01266","RHEA_ID":12327,"DIRECTION":"BI","MASTER_ID":12324,"compounds":"H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine <=> L-asparagine + N-acetyl-D-glucosamine","pmd":114.043}
{"X":1134,"KEGG":"R01267","RHEA_ID":15388,"DIRECTION":"BI","MASTER_ID":15385,"metacyc":"3-CYANOALANINE-HYDRATASE-RXN","compounds":"L-asparagine <=> 3-cyano-L-alanine + H2O","pmd":18.011}
{"X":1135,"KEGG":"R01268","RHEA_ID":14548,"DIRECTION":"BI","MASTER_ID":14545,"compounds":"H2O + nicotinamide <=> NH4(+) + nicotinate","pmd":0.984}
{"X":1136,"KEGG":"R01269","RHEA_ID":23887,"DIRECTION":"BI","MASTER_ID":23884,"compounds":"nicotinamide + S-adenosyl-L-methionine <=> 1-methylnicotinamide + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":1137,"KEGG":"R01269","RHEA_ID":23887,"DIRECTION":"BI","MASTER_ID":23884,"compounds":"nicotinamide + S-adenosyl-L-methionine <=> 1-methylnicotinamide + S-adenosyl-L-homocysteine","pmd":15.023}
{"X":1138,"KEGG":"R01270","RHEA_ID":23143,"DIRECTION":"BI","MASTER_ID":23140,"compounds":"beta-nicotinamide D-ribonucleotide + H2O <=> D-ribose 5-phosphate + H(+) + nicotinamide","pmd":104.037}
{"X":1139,"KEGG":"R01271","RHEA_ID":16152,"DIRECTION":"BI","MASTER_ID":16149,"compounds":"beta-nicotinamide D-ribonucleotide + diphosphate <=> 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide","pmd":55.895}
{"X":1140,"KEGG":"R01273","RHEA_ID":30746,"DIRECTION":"BI","MASTER_ID":30743,"compounds":"beta-nicotinamide D-riboside + H2O <=> D-ribose + H(+) + nicotinamide","pmd":105.045}
{"X":1141,"KEGG":"R01274","RHEA_ID":16648,"DIRECTION":"BI","MASTER_ID":16645,"compounds":"H2O + hexadecanoyl-CoA <=> CoA + H(+) + hexadecanoate"}
{"X":1142,"KEGG":"R01277","RHEA_ID":19708,"DIRECTION":"BI","MASTER_ID":19705,"compounds":"CoA + hexadecanal + NAD(+) <=> H(+) + hexadecanoyl-CoA + NADH","pmd":101.99}
{"X":1143,"KEGG":"R01277","RHEA_ID":19708,"DIRECTION":"BI","MASTER_ID":19705,"compounds":"CoA + hexadecanal + NAD(+) <=> H(+) + hexadecanoyl-CoA + NADH","pmd":424.88}
{"X":1144,"KEGG":"R01279","RHEA_ID":30750,"DIRECTION":"BI","MASTER_ID":30747,"compounds":"FAD + H(+) + hexadecanoyl-CoA <=> (2E)-hexadecenoyl-CoA + FADH2","pmd":2.016}
{"X":1145,"KEGG":"R01280","RHEA_ID":30754,"DIRECTION":"BI","MASTER_ID":30751,"compounds":"ATP + CoA + hexadecanoate <=> AMP + diphosphate + hexadecanoyl-CoA","pmd":420.052}
{"X":1146,"KEGG":"R01280","RHEA_ID":30754,"DIRECTION":"BI","MASTER_ID":30751,"compounds":"ATP + CoA + hexadecanoate <=> AMP + diphosphate + hexadecanoyl-CoA","pmd":90.823}
{"X":1147,"KEGG":"R01280","RHEA_ID":30754,"DIRECTION":"BI","MASTER_ID":30751,"compounds":"ATP + CoA + hexadecanoate <=> AMP + diphosphate + hexadecanoyl-CoA","pmd":159.933}
{"X":1148,"KEGG":"R01281","RHEA_ID":14764,"DIRECTION":"BI","MASTER_ID":14761,"compounds":"H(+) + hexadecanoyl-CoA + L-serine <=> 3-oxosphinganine + CO2 + CoA","pmd":194.24}
{"X":1149,"KEGG":"R01283","RHEA_ID":14504,"DIRECTION":"BI","MASTER_ID":14501,"compounds":"H2O + L-homocysteine <=> 2-oxobutanoate + H(+) + hydrogen sulfide + NH4(+)","pmd":33.004}
{"X":1150,"KEGG":"R01286","RHEA_ID":13968,"DIRECTION":"BI","MASTER_ID":13965,"compounds":"H2O + L,L-cystathionine <=> L-homocysteine + NH4(+) + pyruvate","pmd":87.032}
{"X":1151,"KEGG":"R01287","RHEA_ID":27825,"DIRECTION":"BI","MASTER_ID":27822,"metacyc":"ACETYLHOMOSER-CYS-RXN","compounds":"hydrogen sulfide + O-acetyl-L-homoserine <=> acetate + L-homocysteine","pmd":26.033}
{"X":1152,"KEGG":"R01288","RHEA_ID":27829,"DIRECTION":"BI","MASTER_ID":27826,"metacyc":"RXN-9384","compounds":"hydrogen sulfide + O-succinyl-L-homoserine <=> L-homocysteine + succinate","pmd":84.039}
{"X":1153,"KEGG":"R01290","RHEA_ID":10115,"DIRECTION":"BI","MASTER_ID":10112,"metacyc":"CYSTATHIONINE-BETA-SYNTHASE-RXN","compounds":"L-homocysteine + L-serine <=> H2O + L,L-cystathionine","pmd":117.025}
{"X":1154,"KEGG":"R01290","RHEA_ID":10115,"DIRECTION":"BI","MASTER_ID":10112,"metacyc":"CYSTATHIONINE-BETA-SYNTHASE-RXN","compounds":"L-homocysteine + L-serine <=> H2O + L,L-cystathionine","pmd":87.032}
{"X":1155,"KEGG":"R01291","RHEA_ID":17756,"DIRECTION":"BI","MASTER_ID":17753,"compounds":"S-(5-deoxy-D-ribos-5-yl)-L-homocysteine <=> (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine","pmd":132.042}
{"X":1156,"KEGG":"R01293","RHEA_ID":20308,"DIRECTION":"BI","MASTER_ID":20305,"compounds":"4-hydroxybenzaldehyde + H2O + NAD(+) <=> 4-hydroxybenzoate + 2 H(+) + NADH","pmd":526.085}
{"X":1157,"KEGG":"R01293","RHEA_ID":20308,"DIRECTION":"BI","MASTER_ID":20305,"compounds":"4-hydroxybenzaldehyde + H2O + NAD(+) <=> 4-hydroxybenzoate + 2 H(+) + NADH","pmd":15.995}
{"X":1158,"KEGG":"R01294","RHEA_ID":47939,"DIRECTION":"BI","MASTER_ID":47936,"compounds":"4-hydroxybenzaldehyde + H2O + NADP(+) <=> 4-hydroxybenzoate + 2 H(+) + NADPH","pmd":15.995}
{"X":1159,"KEGG":"R01294","RHEA_ID":47939,"DIRECTION":"BI","MASTER_ID":47936,"compounds":"4-hydroxybenzaldehyde + H2O + NADP(+) <=> 4-hydroxybenzoate + 2 H(+) + NADPH","pmd":606.052}
{"X":1160,"KEGG":"R01295","RHEA_ID":18036,"DIRECTION":"BI","MASTER_ID":18033,"compounds":"benzoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 4-hydroxybenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":1161,"KEGG":"R01296","RHEA_ID":19476,"DIRECTION":"BI","MASTER_ID":19473,"compounds":"4-hydroxybenzoate + H(+) + NADH + O2 <=> 3,4-dihydroxybenzoate + H2O + NAD(+)","pmd":511.098}
{"X":1162,"KEGG":"R01296","RHEA_ID":19476,"DIRECTION":"BI","MASTER_ID":19473,"compounds":"4-hydroxybenzoate + H(+) + NADH + O2 <=> 3,4-dihydroxybenzoate + H2O + NAD(+)","pmd":15.995}
{"X":1163,"KEGG":"R01297","RHEA_ID":16392,"DIRECTION":"BI","MASTER_ID":16389,"compounds":"4-hydroxybenzoate + 2 H(+) + NADH + O2 <=> CO2 + H2O + hydroquinone + NAD(+)","pmd":27.995}
{"X":1164,"KEGG":"R01297","RHEA_ID":16392,"DIRECTION":"BI","MASTER_ID":16389,"compounds":"4-hydroxybenzoate + 2 H(+) + NADH + O2 <=> CO2 + H2O + hydroquinone + NAD(+)","pmd":555.088}
{"X":1165,"KEGG":"R01298","RHEA_ID":19480,"DIRECTION":"BI","MASTER_ID":19477,"compounds":"4-hydroxybenzoate + H(+) + NADPH + O2 <=> 3,4-dihydroxybenzoate + H2O + NADP(+)","pmd":15.995}
{"X":1166,"KEGG":"R01298","RHEA_ID":19480,"DIRECTION":"BI","MASTER_ID":19477,"compounds":"4-hydroxybenzoate + H(+) + NADPH + O2 <=> 3,4-dihydroxybenzoate + H2O + NADP(+)","pmd":591.064}
{"X":1167,"KEGG":"R01299","RHEA_ID":16388,"DIRECTION":"BI","MASTER_ID":16385,"compounds":"4-hydroxybenzoate + 2 H(+) + NADPH + O2 <=> CO2 + H2O + hydroquinone + NADP(+)","pmd":635.054}
{"X":1168,"KEGG":"R01299","RHEA_ID":16388,"DIRECTION":"BI","MASTER_ID":16385,"compounds":"4-hydroxybenzoate + 2 H(+) + NADPH + O2 <=> CO2 + H2O + hydroquinone + NADP(+)","pmd":27.995}
{"X":1169,"KEGG":"R01300","RHEA_ID":23119,"DIRECTION":"BI","MASTER_ID":23116,"metacyc":"4-HYDROXYBENZOATE--COA-LIGASE-RXN","compounds":"4-hydroxybenzoate + ATP + CoA <=> 4-hydroxybenzoyl-CoA + AMP + diphosphate","pmd":159.933}
{"X":1170,"KEGG":"R01300","RHEA_ID":23119,"DIRECTION":"BI","MASTER_ID":23116,"metacyc":"4-HYDROXYBENZOATE--COA-LIGASE-RXN","compounds":"4-hydroxybenzoate + ATP + CoA <=> 4-hydroxybenzoyl-CoA + AMP + diphosphate","pmd":209.031}
{"X":1171,"KEGG":"R01300","RHEA_ID":23119,"DIRECTION":"BI","MASTER_ID":23116,"metacyc":"4-HYDROXYBENZOATE--COA-LIGASE-RXN","compounds":"4-hydroxybenzoate + ATP + CoA <=> 4-hydroxybenzoyl-CoA + AMP + diphosphate","pmd":120.021}
{"X":1172,"KEGG":"R01301","RHEA_ID":11951,"DIRECTION":"BI","MASTER_ID":11948,"compounds":"4-hydroxybenzoyl-CoA + H2O <=> 4-hydroxybenzoate + CoA + H(+)","pmd":120.021}
{"X":1173,"KEGG":"R01302","RHEA_ID":16508,"DIRECTION":"BI","MASTER_ID":16505,"compounds":"chorismate <=> 4-hydroxybenzoate + pyruvate","pmd":88.016}
{"X":1174,"KEGG":"R01304","RHEA_ID":15156,"DIRECTION":"BI","MASTER_ID":15153,"compounds":"4-hydroxybenzoate + UDP-alpha-D-glucose <=> 4-(beta-D-glucosyloxy)benzoate + H(+) + UDP","pmd":162.053}
{"X":1175,"KEGG":"R01305","RHEA_ID":24419,"DIRECTION":"BI","MASTER_ID":24416,"metacyc":"1.13.11.41-RXN","compounds":"2,4'-dihydroxyacetophenone + O2 <=> 4-hydroxybenzoate + formate + 2 H(+)","pmd":14.016}
{"X":1176,"KEGG":"R01306","RHEA_ID":18616,"DIRECTION":"BI","MASTER_ID":18613,"compounds":"4-methoxybenzoate + AH2 + O2 <=> 4-hydroxybenzoate + A + formaldehyde + H2O","pmd":14.016}
{"X":1177,"KEGG":"R01307","RHEA_ID":23443,"DIRECTION":"BI","MASTER_ID":23440,"compounds":"4-chlorobenzoate + H2O <=> 4-hydroxybenzoate + chloride + H(+)","pmd":17.966}
{"X":1178,"KEGG":"R01310","RHEA_ID":14448,"DIRECTION":"BI","MASTER_ID":14445,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)"}
{"X":1179,"KEGG":"R01312","RHEA_ID":10607,"DIRECTION":"BI","MASTER_ID":10604,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O <=> a 1,2-diacyl-sn-glycerol + H(+) + phosphocholine"}
{"X":1180,"KEGG":"R01313","RHEA_ID":15804,"DIRECTION":"BI","MASTER_ID":15801,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O <=> a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)"}
{"X":1181,"KEGG":"R01314","RHEA_ID":18692,"DIRECTION":"BI","MASTER_ID":18689,"metacyc":"RXN-10728","compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O <=> a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)"}
{"X":1182,"KEGG":"R01318","RHEA_ID":12940,"DIRECTION":"BI","MASTER_ID":12937,"metacyc":"2.3.1.23-RXN","compounds":"a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA"}
{"X":1183,"KEGG":"R01319","RHEA_ID":10335,"DIRECTION":"BI","MASTER_ID":10332,"compounds":"a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA"}
{"X":1184,"KEGG":"R01320","RHEA_ID":32742,"DIRECTION":"BI","MASTER_ID":32739,"compounds":"1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":1185,"KEGG":"R01321","RHEA_ID":32942,"DIRECTION":"BI","MASTER_ID":32939,"metacyc":"RXN-5781","compounds":"a 1,2-diacyl-sn-glycerol + CDP-choline <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)","pmd":165.055}
{"X":1186,"KEGG":"R01322","RHEA_ID":21475,"DIRECTION":"BI","MASTER_ID":21472,"compounds":"ATP + citrate + CoA <=> (3S)-citryl-CoA + ADP + phosphate","pmd":235.002}
{"X":1187,"KEGG":"R01322","RHEA_ID":21475,"DIRECTION":"BI","MASTER_ID":21472,"compounds":"ATP + citrate + CoA <=> (3S)-citryl-CoA + ADP + phosphate","pmd":174.016}
{"X":1188,"KEGG":"R01322","RHEA_ID":21475,"DIRECTION":"BI","MASTER_ID":21472,"compounds":"ATP + citrate + CoA <=> (3S)-citryl-CoA + ADP + phosphate","pmd":79.966}
{"X":1189,"KEGG":"R01323","RHEA_ID":19408,"DIRECTION":"BI","MASTER_ID":19405,"metacyc":"2.8.3.10-RXN","compounds":"acetyl-CoA + citrate <=> (3S)-citryl-CoA + acetate","pmd":132.006}
{"X":1190,"KEGG":"R01323","RHEA_ID":19408,"DIRECTION":"BI","MASTER_ID":19405,"metacyc":"2.8.3.10-RXN","compounds":"acetyl-CoA + citrate <=> (3S)-citryl-CoA + acetate","pmd":749.105}
{"X":1191,"KEGG":"R01324","RHEA_ID":10339,"DIRECTION":"BI","MASTER_ID":10336,"ecocyc":"RXN-14047","metacyc":"RXN-14047","compounds":"citrate <=> isocitrate","pmd":0}
{"X":1192,"KEGG":"R01325","RHEA_ID":10231,"DIRECTION":"BI","MASTER_ID":10228,"ecocyc":"ACONITATEDEHYDR-RXN","metacyc":"ACONITATEDEHYDR-RXN","compounds":"citrate <=> cis-aconitate + H2O","pmd":18.011}
{"X":1193,"KEGG":"R01326","RHEA_ID":11031,"DIRECTION":"BI","MASTER_ID":11028,"compounds":"ATP + D-mannose <=> ADP + D-mannose 6-phosphate + H(+)","pmd":79.966}
{"X":1194,"KEGG":"R01328","RHEA_ID":12992,"DIRECTION":"BI","MASTER_ID":12989,"compounds":"dolichyl beta-D-mannosyl phosphate + H2O <=> D-mannose + dolichyl phosphate + H(+)"}
{"X":1195,"KEGG":"R01333","RHEA_ID":20004,"DIRECTION":"BI","MASTER_ID":20001,"compounds":"glycolaldehyde + H2O + NAD(+) <=> glycolate + 2 H(+) + NADH"}
{"X":1196,"KEGG":"R01334","RHEA_ID":14372,"DIRECTION":"BI","MASTER_ID":14369,"compounds":"2-phosphoglycolate + H2O <=> glycolate + phosphate"}
{"X":1197,"KEGG":"R01336","RHEA_ID":12339,"DIRECTION":"BI","MASTER_ID":12336,"compounds":"carboxymethoxysuccinate <=> fumarate + glycolate","pmd":76.016}
{"X":1198,"KEGG":"R01337","RHEA_ID":22279,"DIRECTION":"BI","MASTER_ID":22276,"compounds":"2-oxoaldehyde + H2O + NAD(+) <=> a 2-oxocarboxylate + 2 H(+) + NADH"}
{"X":1199,"KEGG":"R01338","RHEA_ID":18132,"DIRECTION":"BI","MASTER_ID":18129,"compounds":"2-oxoaldehyde + H2O + NADP(+) <=> a 2-oxocarboxylate + 2 H(+) + NADPH"}
{"X":1200,"KEGG":"R01340","RHEA_ID":21819,"DIRECTION":"BI","MASTER_ID":21816,"compounds":"a D-alpha-amino acid + H2O + O2 <=> a 2-oxocarboxylate + H2O2 + NH4(+)"}
{"X":1201,"KEGG":"R01341","RHEA_ID":16792,"DIRECTION":"BI","MASTER_ID":16789,"compounds":"a (2S)-2-hydroxycarboxylate + O2 <=> a 2-oxocarboxylate + H2O2"}
{"X":1202,"KEGG":"R01343","RHEA_ID":13880,"DIRECTION":"BI","MASTER_ID":13877,"metacyc":"ORNITHINE--OXO-ACID-AMINOTRANSFERASE-RXN","compounds":"a 2-oxocarboxylate + L-ornithine <=> an L-alpha-amino acid + L-glutamate 5-semialdehyde","pmd":1.032}
{"X":1203,"KEGG":"R01346","RHEA_ID":19816,"DIRECTION":"BI","MASTER_ID":19813,"metacyc":"2.6.1.14-RXN","compounds":"a 2-oxocarboxylate + L-asparagine <=> 2-oxosuccinamate + an L-alpha-amino acid","pmd":1.032}
{"X":1204,"KEGG":"R01349","RHEA_ID":23015,"DIRECTION":"BI","MASTER_ID":23012,"compounds":"a fatty acid + S-adenosyl-L-methionine <=> a fatty acid methyl ester + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":1205,"KEGG":"R01351","RHEA_ID":34022,"DIRECTION":"BI","MASTER_ID":34019,"compounds":"a 1-acylglycerol + H2O <=> a fatty acid + glycerol + H(+)"}
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{"X":1306,"KEGG":"R01463","RHEA_ID":21815,"DIRECTION":"BI","MASTER_ID":21812,"compounds":"cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":1307,"KEGG":"R01465","RHEA_ID":13164,"DIRECTION":"BI","MASTER_ID":13161,"compounds":"L-threonine + NAD(+) <=> (2S)-2-amino-3-oxobutanoate + H(+) + NADH","pmd":547.074}
{"X":1308,"KEGG":"R01465","RHEA_ID":13164,"DIRECTION":"BI","MASTER_ID":13161,"compounds":"L-threonine + NAD(+) <=> (2S)-2-amino-3-oxobutanoate + H(+) + NADH","pmd":2.016}
{"X":1309,"KEGG":"R01466","RHEA_ID":10843,"DIRECTION":"BI","MASTER_ID":10840,"compounds":"H2O + O-phospho-L-homoserine <=> L-threonine + phosphate","pmd":79.966}
{"X":1310,"KEGG":"R01467","RHEA_ID":13916,"DIRECTION":"BI","MASTER_ID":13913,"compounds":"L-threonine <=> D-threonine","pmd":0}
{"X":1311,"KEGG":"R01468","RHEA_ID":13072,"DIRECTION":"BI","MASTER_ID":13069,"compounds":"ATP + ethanolamine <=> ADP + H(+) + phosphoethanolamine","pmd":79.966}
{"X":1312,"KEGG":"R01469","RHEA_ID":18584,"DIRECTION":"BI","MASTER_ID":18581,"compounds":"ethanolamine + H2O + O2 <=> glycolaldehyde + H2O2 + NH4(+)"}
{"X":1313,"KEGG":"R01470","RHEA_ID":29322,"DIRECTION":"BI","MASTER_ID":29319,"compounds":"H2O + sn-glycero-3-phosphoethanolamine <=> ethanolamine + H(+) + sn-glycerol 3-phosphate","pmd":43.042}
{"X":1314,"KEGG":"R01471","RHEA_ID":18392,"DIRECTION":"BI","MASTER_ID":18389,"metacyc":"2.7.7.11-RXN","compounds":"alpha-D-xylose 1-phosphate + H(+) + UTP <=> diphosphate + UDP-alpha-D-xylose","pmd":52.076}
{"X":1315,"KEGG":"R01471","RHEA_ID":18392,"DIRECTION":"BI","MASTER_ID":18389,"metacyc":"2.7.7.11-RXN","compounds":"alpha-D-xylose 1-phosphate + H(+) + UTP <=> diphosphate + UDP-alpha-D-xylose","pmd":306.025}
{"X":1316,"KEGG":"R01472","RHEA_ID":15364,"DIRECTION":"BI","MASTER_ID":15361,"compounds":"dolichyl phosphate + UDP-alpha-D-xylose <=> dolichyl D-xylosyl phosphate + UDP","pmd":132.042}
{"X":1317,"KEGG":"R01473","RHEA_ID":11323,"DIRECTION":"BI","MASTER_ID":11320,"metacyc":"UDP-ARABINOSE-4-EPIMERASE-RXN","compounds":"UDP-beta-L-arabinopyranose <=> UDP-alpha-D-xylose","pmd":0}
{"X":1318,"KEGG":"R01476","RHEA_ID":17008,"DIRECTION":"BI","MASTER_ID":17005,"compounds":"ATP + D-glucuronate <=> 1-phospho-alpha-D-glucuronate + ADP + H(+)","pmd":79.966}
{"X":1319,"KEGG":"R01478","RHEA_ID":17636,"DIRECTION":"BI","MASTER_ID":17633,"compounds":"a beta-D-glucuronoside + H2O <=> an alcohol + D-glucuronate"}
{"X":1320,"KEGG":"R01480","RHEA_ID":20008,"DIRECTION":"BI","MASTER_ID":20005,"compounds":"an alpha-D-glucuronoside + H2O <=> an alcohol + D-glucuronate"}
{"X":1321,"KEGG":"R01481","RHEA_ID":14912,"DIRECTION":"BI","MASTER_ID":14909,"compounds":"L-gulonate + NADP(+) <=> aldehydo-D-glucuronate + H(+) + NADPH","pmd":2.016}
{"X":1322,"KEGG":"R01481","RHEA_ID":14912,"DIRECTION":"BI","MASTER_ID":14909,"compounds":"L-gulonate + NADP(+) <=> aldehydo-D-glucuronate + H(+) + NADPH","pmd":550.041}
{"X":1323,"KEGG":"R01482","RHEA_ID":13052,"DIRECTION":"BI","MASTER_ID":13049,"ecocyc":"GLUCUROISOM-RXN","metacyc":"GLUCUROISOM-RXN","compounds":"D-glucuronate <=> D-fructuronate","pmd":0}
{"X":1324,"KEGG":"R01483","RHEA_ID":30770,"DIRECTION":"BI","MASTER_ID":30767,"compounds":"D-glucurono-3,6-lactone + H2O <=> D-glucuronate + H(+)","pmd":18.011}
{"X":1325,"KEGG":"R01484","RHEA_ID":13340,"DIRECTION":"BI","MASTER_ID":13337,"compounds":"D-glucurono-6,2-lactone + H2O <=> D-glucuronate + H(+)","pmd":18.011}
{"X":1326,"KEGG":"R01485","RHEA_ID":11255,"DIRECTION":"BI","MASTER_ID":11252,"compounds":"H(+) + hydroxylamine + L-asparagine <=> beta-L-aspartylhydroxamate + NH4(+)","pmd":15.995}
{"X":1327,"KEGG":"R01486","RHEA_ID":11807,"DIRECTION":"BI","MASTER_ID":11804,"compounds":"an aromatic aldehyde + H2O + NAD(+) <=> an aromatic carboxylate + 2 H(+) + NADH","pmd":542.08}
{"X":1328,"KEGG":"R01486","RHEA_ID":11807,"DIRECTION":"BI","MASTER_ID":11804,"compounds":"an aromatic aldehyde + H2O + NAD(+) <=> an aromatic carboxylate + 2 H(+) + NADH","pmd":15.995}
{"X":1329,"KEGG":"R01487","RHEA_ID":12079,"DIRECTION":"BI","MASTER_ID":12076,"compounds":"an aromatic primary alcohol + NAD(+) <=> an aromatic aldehyde + H(+) + NADH","pmd":2.016}
{"X":1330,"KEGG":"R01487","RHEA_ID":12079,"DIRECTION":"BI","MASTER_ID":12076,"compounds":"an aromatic primary alcohol + NAD(+) <=> an aromatic aldehyde + H(+) + NADH","pmd":558.075}
{"X":1331,"KEGG":"R01488","RHEA_ID":17764,"DIRECTION":"BI","MASTER_ID":17761,"metacyc":"ARYL-ALCOHOL-DEHYDROGENASE-NADP%2b-RXN","compounds":"an aromatic primary alcohol + NADP(+) <=> an aromatic aldehyde + H(+) + NADPH","pmd":638.041}
{"X":1332,"KEGG":"R01488","RHEA_ID":17764,"DIRECTION":"BI","MASTER_ID":17761,"metacyc":"ARYL-ALCOHOL-DEHYDROGENASE-NADP%2b-RXN","compounds":"an aromatic primary alcohol + NADP(+) <=> an aromatic aldehyde + H(+) + NADPH","pmd":2.016}
{"X":1333,"KEGG":"R01489","RHEA_ID":18572,"DIRECTION":"BI","MASTER_ID":18569,"compounds":"an aromatic aldehyde + H2O + O2 <=> an aromatic carboxylate + H(+) + H2O2","pmd":15.995}
{"X":1334,"KEGG":"R01490","RHEA_ID":19232,"DIRECTION":"BI","MASTER_ID":19229,"compounds":"AMP + an aromatic aldehyde + diphosphate + NADP(+) <=> an aromatic carboxylate + ATP + H(+) + NADPH","pmd":15.995}
{"X":1335,"KEGG":"R01490","RHEA_ID":19232,"DIRECTION":"BI","MASTER_ID":19229,"compounds":"AMP + an aromatic aldehyde + diphosphate + NADP(+) <=> an aromatic carboxylate + ATP + H(+) + NADPH","pmd":159.933}
{"X":1336,"KEGG":"R01490","RHEA_ID":19232,"DIRECTION":"BI","MASTER_ID":19229,"compounds":"AMP + an aromatic aldehyde + diphosphate + NADP(+) <=> an aromatic carboxylate + ATP + H(+) + NADPH","pmd":237.088}
{"X":1337,"KEGG":"R01491","RHEA_ID":17544,"DIRECTION":"BI","MASTER_ID":17541,"compounds":"an aromatic primary alcohol + O2 <=> an aromatic aldehyde + H2O2","pmd":2.016}
{"X":1338,"KEGG":"R01492","RHEA_ID":28674,"DIRECTION":"BI","MASTER_ID":28671,"compounds":"2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] <=> 2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate"}
{"X":1339,"KEGG":"R01493","RHEA_ID":20859,"DIRECTION":"BI","MASTER_ID":20856,"compounds":"an N-acylsphing-4-enine + H2O <=> a fatty acid + sphing-4-enine"}
{"X":1340,"KEGG":"R01495","RHEA_ID":17932,"DIRECTION":"BI","MASTER_ID":17929,"metacyc":"CERAMIDE-KINASE-RXN","compounds":"an N-acylsphing-4-enine + ATP <=> ADP + H(+) + N-acylsphing-4-enine 1-phosphate","pmd":79.966}
{"X":1341,"KEGG":"R01496","RHEA_ID":23771,"DIRECTION":"BI","MASTER_ID":23768,"metacyc":"SPHINGOSINE-N-ACYLTRANSFERASE-RXN","compounds":"an acyl-CoA + sphing-4-enine <=> an N-acylsphing-4-enine + CoA + H(+)","pmd":467.833}
{"X":1342,"KEGG":"R01497","RHEA_ID":12091,"DIRECTION":"BI","MASTER_ID":12088,"metacyc":"CERAMIDE-GLUCOSYLTRANSFERASE-RXN","compounds":"an N-acylsphing-4-enine + UDP-alpha-D-glucose <=> a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP","pmd":162.053}
{"X":1343,"KEGG":"R01498","RHEA_ID":13272,"DIRECTION":"BI","MASTER_ID":13269,"compounds":"a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O <=> an N-acylsphing-4-enine + D-glucose"}
{"X":1344,"KEGG":"R01500","RHEA_ID":13096,"DIRECTION":"BI","MASTER_ID":13093,"compounds":"an N-acylsphing-4-enine + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP","pmd":162.053}
{"X":1345,"KEGG":"R01504","RHEA_ID":20232,"DIRECTION":"BI","MASTER_ID":20229,"compounds":"2,3-dihydroxybenzoate + ATP + H(+) <=> 2,3-dihydroxybenzoyl-5'-AMP + diphosphate","pmd":329.053}
{"X":1346,"KEGG":"R01504","RHEA_ID":20232,"DIRECTION":"BI","MASTER_ID":20229,"compounds":"2,3-dihydroxybenzoate + ATP + H(+) <=> 2,3-dihydroxybenzoyl-5'-AMP + diphosphate","pmd":23.917}
{"X":1347,"KEGG":"R01505","RHEA_ID":23827,"DIRECTION":"BI","MASTER_ID":23824,"compounds":"(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD(+) <=> 2,3-dihydroxybenzoate + H(+) + NADH","pmd":2.016}
{"X":1348,"KEGG":"R01505","RHEA_ID":23827,"DIRECTION":"BI","MASTER_ID":23824,"compounds":"(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD(+) <=> 2,3-dihydroxybenzoate + H(+) + NADH","pmd":510.09}
{"X":1349,"KEGG":"R01506","RHEA_ID":15372,"DIRECTION":"BI","MASTER_ID":15369,"compounds":"2,3-dihydroxybenzoate + O2 <=> 2-carboxy-cis,cis-muconate + 2 H(+)","pmd":31.99}
{"X":1350,"KEGG":"R01507","RHEA_ID":18480,"DIRECTION":"BI","MASTER_ID":18477,"compounds":"2,3-dihydroxybenzoate + O2 <=> 2-hydroxy-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+)","pmd":31.99}
{"X":1351,"KEGG":"R01508","RHEA_ID":14196,"DIRECTION":"BI","MASTER_ID":14193,"compounds":"3-hydroxybenzoate + AH2 + O2 <=> 2,3-dihydroxybenzoate + A + H2O","pmd":15.995}
{"X":1352,"KEGG":"R01511","RHEA_ID":12415,"DIRECTION":"BI","MASTER_ID":12412,"compounds":"(2R)-3-phosphoglycerate + H2O <=> (R)-glycerate + phosphate","pmd":79.966}
{"X":1353,"KEGG":"R01512","RHEA_ID":14804,"DIRECTION":"BI","MASTER_ID":14801,"ecocyc":"PHOSGLYPHOS-RXN","metacyc":"PHOSGLYPHOS-RXN","compounds":"(2R)-3-phosphoglycerate + ATP <=> (2R)-3-phospho-glyceroyl phosphate + ADP","pmd":79.966}
{"X":1354,"KEGG":"R01513","RHEA_ID":12644,"DIRECTION":"BI","MASTER_ID":12641,"ecocyc":"PGLYCDEHYDROG-RXN","metacyc":"PGLYCDEHYDROG-RXN","compounds":"(2R)-3-phosphoglycerate + NAD(+) <=> 3-phosphooxypyruvate + H(+) + NADH","pmd":2.016}
{"X":1355,"KEGG":"R01513","RHEA_ID":12644,"DIRECTION":"BI","MASTER_ID":12641,"ecocyc":"PGLYCDEHYDROG-RXN","metacyc":"PGLYCDEHYDROG-RXN","compounds":"(2R)-3-phosphoglycerate + NAD(+) <=> 3-phosphooxypyruvate + H(+) + NADH","pmd":480.14}
{"X":1356,"KEGG":"R01514","RHEA_ID":23519,"DIRECTION":"BI","MASTER_ID":23516,"compounds":"(R)-glycerate + ATP <=> (2R)-3-phosphoglycerate + ADP + H(+)","pmd":79.966}
{"X":1357,"KEGG":"R01516","RHEA_ID":21907,"DIRECTION":"BI","MASTER_ID":21904,"compounds":"(2R)-2,3-bisphosphoglycerate + H2O <=> (2R)-3-phosphoglycerate + phosphate","pmd":79.966}
{"X":1358,"KEGG":"R01517","RHEA_ID":23335,"DIRECTION":"BI","MASTER_ID":23332,"compounds":"(2R)-3-phosphoglycerate + GTP <=> (2R)-3-phospho-glyceroyl phosphate + GDP","pmd":79.966}
{"X":1359,"KEGG":"R01518","RHEA_ID":15904,"DIRECTION":"BI","MASTER_ID":15901,"ecocyc":"3PGAREARR-RXN","metacyc":"3PGAREARR-RXN","compounds":"(2R)-2-phosphoglycerate <=> (2R)-3-phosphoglycerate","pmd":0}
{"X":1360,"KEGG":"R01519","RHEA_ID":10443,"DIRECTION":"BI","MASTER_ID":10440,"compounds":"D-glucono-1,5-lactone + H2O <=> D-gluconate + H(+)","pmd":18.011}
{"X":1361,"KEGG":"R01520","RHEA_ID":13652,"DIRECTION":"BI","MASTER_ID":13649,"metacyc":"GLUCOSE-1-DEHYDROGENASE-RXN","compounds":"beta-D-glucose + NAD(+) <=> D-glucono-1,5-lactone + H(+) + NADH","pmd":486.069}
{"X":1362,"KEGG":"R01520","RHEA_ID":13652,"DIRECTION":"BI","MASTER_ID":13649,"metacyc":"GLUCOSE-1-DEHYDROGENASE-RXN","compounds":"beta-D-glucose + NAD(+) <=> D-glucono-1,5-lactone + H(+) + NADH","pmd":2.016}
{"X":1363,"KEGG":"R01521","RHEA_ID":13648,"DIRECTION":"BI","MASTER_ID":13645,"metacyc":"GLUCOSE-1-DEHYDROGENASE-RXN","compounds":"beta-D-glucose + NADP(+) <=> D-glucono-1,5-lactone + H(+) + NADPH","pmd":2.016}
{"X":1364,"KEGG":"R01521","RHEA_ID":13648,"DIRECTION":"BI","MASTER_ID":13645,"metacyc":"GLUCOSE-1-DEHYDROGENASE-RXN","compounds":"beta-D-glucose + NADP(+) <=> D-glucono-1,5-lactone + H(+) + NADPH","pmd":566.036}
{"X":1365,"KEGG":"R01522","RHEA_ID":11431,"DIRECTION":"BI","MASTER_ID":11428,"compounds":"beta-D-glucose + O2 <=> D-glucono-1,5-lactone + H2O2","pmd":2.016}
{"X":1366,"KEGG":"R01523","RHEA_ID":19368,"DIRECTION":"BI","MASTER_ID":19365,"metacyc":"PHOSPHORIBULOKINASE-RXN","compounds":"ATP + D-ribulose 5-phosphate <=> ADP + D-ribulose 1,5-bisphosphate + H(+)","pmd":79.966}
{"X":1367,"KEGG":"R01524","RHEA_ID":19928,"DIRECTION":"BI","MASTER_ID":19925,"compounds":"D-ribitol 5-phosphate + NAD(+) <=> D-ribulose 5-phosphate + H(+) + NADH","pmd":434.098}
{"X":1368,"KEGG":"R01524","RHEA_ID":19928,"DIRECTION":"BI","MASTER_ID":19925,"compounds":"D-ribitol 5-phosphate + NAD(+) <=> D-ribulose 5-phosphate + H(+) + NADH","pmd":2.016}
{"X":1369,"KEGG":"R01525","RHEA_ID":19924,"DIRECTION":"BI","MASTER_ID":19921,"compounds":"D-ribitol 5-phosphate + NADP(+) <=> D-ribulose 5-phosphate + H(+) + NADPH","pmd":2.016}
{"X":1370,"KEGG":"R01525","RHEA_ID":19924,"DIRECTION":"BI","MASTER_ID":19921,"compounds":"D-ribitol 5-phosphate + NADP(+) <=> D-ribulose 5-phosphate + H(+) + NADPH","pmd":514.064}
{"X":1371,"KEGG":"R01526","RHEA_ID":17604,"DIRECTION":"BI","MASTER_ID":17601,"metacyc":"D-RIBULOKIN-RXN","compounds":"ATP + D-ribulose <=> ADP + D-ribulose 5-phosphate + H(+)","pmd":79.966}
{"X":1372,"KEGG":"R01528","RHEA_ID":10119,"DIRECTION":"BI","MASTER_ID":10116,"compounds":"6-phospho-D-gluconate + NADP(+) <=> CO2 + D-ribulose 5-phosphate + NADPH","pmd":46.005}
{"X":1373,"KEGG":"R01528","RHEA_ID":10119,"DIRECTION":"BI","MASTER_ID":10116,"compounds":"6-phospho-D-gluconate + NADP(+) <=> CO2 + D-ribulose 5-phosphate + NADPH","pmd":514.064}
{"X":1374,"KEGG":"R01529","RHEA_ID":13680,"DIRECTION":"BI","MASTER_ID":13677,"ecocyc":"RIBULP3EPIM-RXN","metacyc":"RIBULP3EPIM-RXN","compounds":"D-ribulose 5-phosphate <=> D-xylulose 5-phosphate","pmd":0}
{"X":1375,"KEGG":"R01530","RHEA_ID":23107,"DIRECTION":"BI","MASTER_ID":23104,"ecocyc":"DARAB5PISOM-RXN","metacyc":"DARAB5PISOM-RXN","compounds":"D-arabinose 5-phosphate <=> D-ribulose 5-phosphate","pmd":0}
{"X":1376,"KEGG":"R01532","RHEA_ID":23999,"DIRECTION":"BI","MASTER_ID":23996,"compounds":"a ribonucleoside 5'-triphosphate + H2O <=> a ribonucleoside 5'-phosphate + diphosphate + H(+)"}
{"X":1377,"KEGG":"R01533","RHEA_ID":24103,"DIRECTION":"BI","MASTER_ID":24100,"metacyc":"DIISOPROPYL-FLUOROPHOSPHATASE-RXN","compounds":"diisopropyl fluorophosphate + H2O <=> diisopropyl phosphate + fluoride + 2 H(+)","pmd":1.996}
{"X":1378,"KEGG":"R01535","RHEA_ID":28117,"DIRECTION":"BI","MASTER_ID":28114,"metacyc":"2.7.8.6-RXN","compounds":"di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-glucose <=> alpha-D-galactosyl-diphosphoundecaprenol + UMP","pmd":522.63}
{"X":1379,"KEGG":"R01535","RHEA_ID":28117,"DIRECTION":"BI","MASTER_ID":28114,"metacyc":"2.7.8.6-RXN","compounds":"di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-glucose <=> alpha-D-galactosyl-diphosphoundecaprenol + UMP","pmd":242.019}
{"X":1380,"KEGG":"R01535","RHEA_ID":11655,"DIRECTION":"BI","MASTER_ID":11652,"metacyc":"2.7.8.6-RXN","compounds":"di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-galactose <=> alpha-D-galactosyl di-trans,octa-cis-undecaprenyl diphosphate + UMP","pmd":522.63}
{"X":1381,"KEGG":"R01535","RHEA_ID":11655,"DIRECTION":"BI","MASTER_ID":11652,"metacyc":"2.7.8.6-RXN","compounds":"di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-galactose <=> alpha-D-galactosyl di-trans,octa-cis-undecaprenyl diphosphate + UMP","pmd":242.019}
{"X":1382,"KEGG":"R01538","RHEA_ID":21615,"DIRECTION":"BI","MASTER_ID":21612,"compounds":"D-gluconate <=> 2-dehydro-3-deoxy-D-gluconate + H2O","pmd":18.011}
{"X":1383,"KEGG":"R01540","RHEA_ID":15960,"DIRECTION":"BI","MASTER_ID":15957,"compounds":"D-altronate <=> 2-dehydro-3-deoxy-D-gluconate + H2O","pmd":18.011}
{"X":1384,"KEGG":"R01541","RHEA_ID":14800,"DIRECTION":"BI","MASTER_ID":14797,"compounds":"2-dehydro-3-deoxy-D-gluconate + ATP <=> 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + H(+)","pmd":79.966}
{"X":1385,"KEGG":"R01542","RHEA_ID":24235,"DIRECTION":"BI","MASTER_ID":24232,"ecocyc":"1.1.1.127-RXN","metacyc":"1.1.1.127-RXN","compounds":"2-dehydro-3-deoxy-D-gluconate + NAD(+) <=> 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH","pmd":2.016}
{"X":1386,"KEGG":"R01542","RHEA_ID":24235,"DIRECTION":"BI","MASTER_ID":24232,"ecocyc":"1.1.1.127-RXN","metacyc":"1.1.1.127-RXN","compounds":"2-dehydro-3-deoxy-D-gluconate + NAD(+) <=> 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH","pmd":488.085}
{"X":1387,"KEGG":"R01543","RHEA_ID":15112,"DIRECTION":"BI","MASTER_ID":15109,"compounds":"2-dehydro-3-deoxy-D-gluconate + NADP(+) <=> (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + H(+) + NADPH","pmd":568.051}
{"X":1388,"KEGG":"R01543","RHEA_ID":15112,"DIRECTION":"BI","MASTER_ID":15109,"compounds":"2-dehydro-3-deoxy-D-gluconate + NADP(+) <=> (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + H(+) + NADPH","pmd":2.016}
{"X":1389,"KEGG":"R01544","RHEA_ID":12491,"DIRECTION":"BI","MASTER_ID":12488,"metacyc":"4.3.1.21-RXN","compounds":"2-amino-2-deoxy-D-gluconate <=> 2-dehydro-3-deoxy-D-gluconate + NH4(+)","pmd":17.027}
{"X":1390,"KEGG":"R01547","RHEA_ID":23103,"DIRECTION":"BI","MASTER_ID":23100,"compounds":"ATP + dAMP <=> ADP + dADP","pmd":79.966}
{"X":1391,"KEGG":"R01550","RHEA_ID":21795,"DIRECTION":"BI","MASTER_ID":21792,"metacyc":"ISOPROPANOL-DEHYDROGENASE-NADP%2b-RXN","compounds":"NADP(+) + propan-2-ol <=> acetone + H(+) + NADPH"}
{"X":1392,"KEGG":"R01553","RHEA_ID":11935,"DIRECTION":"BI","MASTER_ID":11932,"compounds":"2-hydroxy-2-methylpropanenitrile <=> acetone + hydrogen cyanide"}
{"X":1393,"KEGG":"R01555","RHEA_ID":21119,"DIRECTION":"BI","MASTER_ID":21116,"metacyc":"MALTOSE-PHOSPHORYLASE-RXN","compounds":"D-maltose + phosphate <=> beta-D-glucose 1-phosphate + D-glucose","pmd":82.087}
{"X":1394,"KEGG":"R01556","RHEA_ID":10459,"DIRECTION":"BI","MASTER_ID":10456,"ecocyc":"MALTACETYLTRAN-RXN","metacyc":"MALTACETYLTRAN-RXN","compounds":"acetyl-CoA + D-maltose <=> 1-O-acetylmaltose + CoA","pmd":42.011}
{"X":1395,"KEGG":"R01557","RHEA_ID":15148,"DIRECTION":"BI","MASTER_ID":15145,"metacyc":"5.4.99.16-RXN","compounds":"D-maltose <=> alpha,alpha-trehalose","pmd":0}
{"X":1396,"KEGG":"R01558","RHEA_ID":18296,"DIRECTION":"BI","MASTER_ID":18293,"compounds":"ATP + CoA + oxalate <=> AMP + diphosphate + oxalyl-CoA","pmd":159.933}
{"X":1397,"KEGG":"R01558","RHEA_ID":18296,"DIRECTION":"BI","MASTER_ID":18293,"compounds":"ATP + CoA + oxalate <=> AMP + diphosphate + oxalyl-CoA","pmd":71.985}
{"X":1398,"KEGG":"R01559","RHEA_ID":23591,"DIRECTION":"BI","MASTER_ID":23588,"metacyc":"OXALATE-COA-TRANSFERASE-RXN","compounds":"oxalate + succinyl-CoA <=> oxalyl-CoA + succinate","pmd":28.031}
{"X":1399,"KEGG":"R01560","RHEA_ID":24411,"DIRECTION":"BI","MASTER_ID":24408,"ecocyc":"ADENODEAMIN-RXN","metacyc":"ADENODEAMIN-RXN","compounds":"adenosine + H(+) + H2O <=> inosine + NH4(+)","pmd":0.984}
{"X":1400,"KEGG":"R01561","RHEA_ID":27645,"DIRECTION":"BI","MASTER_ID":27642,"ecocyc":"ADENPHOSPHOR-RXN","metacyc":"ADENPHOSPHOR-RXN","compounds":"adenosine + phosphate <=> adenine + alpha-D-ribose 1-phosphate","pmd":37.078}
{"X":1401,"KEGG":"R01562","RHEA_ID":27901,"DIRECTION":"BI","MASTER_ID":27898,"compounds":"3'-AMP + H2O <=> adenosine + phosphate","pmd":79.966}
{"X":1402,"KEGG":"R01563","RHEA_ID":20060,"DIRECTION":"BI","MASTER_ID":20057,"compounds":"2 H(+) + H2O + N-carbamoylsarcosine <=> CO2 + NH4(+) + sarcosine"}
{"X":1403,"KEGG":"R01564","RHEA_ID":17080,"DIRECTION":"BI","MASTER_ID":17077,"metacyc":"DIMETHYLGLYCINE-OXIDASE-RXN","compounds":"H2O + N,N-dimethylglycine + O2 <=> formaldehyde + H2O2 + sarcosine"}
{"X":1404,"KEGG":"R01565","RHEA_ID":52859,"DIRECTION":"BI","MASTER_ID":52856,"compounds":"(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n + H(+) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] <=> (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + reduced [electron-transfer flavoprotein] + sarcosine","pmd":354.108}
{"X":1405,"KEGG":"R01565","RHEA_ID":52859,"DIRECTION":"BI","MASTER_ID":52856,"compounds":"(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n + H(+) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] <=> (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + reduced [electron-transfer flavoprotein] + sarcosine","pmd":12}
{"X":1406,"KEGG":"R01566","RHEA_ID":22459,"DIRECTION":"BI","MASTER_ID":22456,"compounds":"creatine + H2O <=> sarcosine + urea"}
{"X":1407,"KEGG":"R01567","RHEA_ID":19132,"DIRECTION":"BI","MASTER_ID":19129,"compounds":"ATP + thymidine <=> ADP + dTMP + H(+)","pmd":79.966}
{"X":1408,"KEGG":"R01568","RHEA_ID":13416,"DIRECTION":"BI","MASTER_ID":13413,"compounds":"ADP + thymidine <=> AMP + dTMP + H(+)","pmd":79.966}
{"X":1409,"KEGG":"R01569","RHEA_ID":11083,"DIRECTION":"BI","MASTER_ID":11080,"compounds":"dTMP + H2O <=> phosphate + thymidine","pmd":79.966}
{"X":1410,"KEGG":"R01570","RHEA_ID":16040,"DIRECTION":"BI","MASTER_ID":16037,"ecocyc":"THYM-PHOSPH-RXN","metacyc":"THYM-PHOSPH-RXN","compounds":"phosphate + thymidine <=> 2-deoxy-alpha-D-ribose 1-phosphate + thymine","pmd":28.066}
{"X":1411,"KEGG":"R01571","RHEA_ID":14916,"DIRECTION":"BI","MASTER_ID":14913,"compounds":"AMP + thymidine <=> adenosine + dTMP","pmd":25.006}
{"X":1412,"KEGG":"R01571","RHEA_ID":14916,"DIRECTION":"BI","MASTER_ID":14913,"compounds":"AMP + thymidine <=> adenosine + dTMP","pmd":25.007}
{"X":1413,"KEGG":"R01572","RHEA_ID":22143,"DIRECTION":"BI","MASTER_ID":22140,"compounds":"a nucleoside 5'-phosphate + H2O <=> a nucleoside + phosphate"}
{"X":1414,"KEGG":"R01573","RHEA_ID":24591,"DIRECTION":"BI","MASTER_ID":24588,"compounds":"ATP + D-arabinose <=> ADP + D-arabinose 5-phosphate + H(+)","pmd":79.966}
{"X":1415,"KEGG":"R01574","RHEA_ID":20460,"DIRECTION":"BI","MASTER_ID":20457,"compounds":"D-arabinose + NAD(+) <=> D-arabinono-1,4-lactone + H(+) + NADH","pmd":2.016}
{"X":1416,"KEGG":"R01574","RHEA_ID":20460,"DIRECTION":"BI","MASTER_ID":20457,"compounds":"D-arabinose + NAD(+) <=> D-arabinono-1,4-lactone + H(+) + NADH","pmd":516.08}
{"X":1417,"KEGG":"R01575","RHEA_ID":21895,"DIRECTION":"BI","MASTER_ID":21892,"compounds":"D-arabinose + NADP(+) <=> D-arabinono-1,4-lactone + H(+) + NADPH","pmd":2.016}
{"X":1418,"KEGG":"R01575","RHEA_ID":21895,"DIRECTION":"BI","MASTER_ID":21892,"compounds":"D-arabinose + NADP(+) <=> D-arabinono-1,4-lactone + H(+) + NADPH","pmd":596.046}
{"X":1419,"KEGG":"R01576","RHEA_ID":23343,"DIRECTION":"BI","MASTER_ID":23340,"compounds":"3-deoxy-alpha-D-manno-oct-2-ulosonate <=> D-arabinose + pyruvate","pmd":88.016}
{"X":1420,"KEGG":"R01577","RHEA_ID":13852,"DIRECTION":"BI","MASTER_ID":13849,"ecocyc":"DARABISOM-RXN","metacyc":"DARABISOM-RXN","compounds":"D-arabinose <=> D-ribulose","pmd":0}
{"X":1421,"KEGG":"R01579","RHEA_ID":22843,"DIRECTION":"BI","MASTER_ID":22840,"metacyc":"D-GLUTAMINASE-RXN","compounds":"D-glutamine + H2O <=> D-glutamate + NH4(+)","pmd":0.984}
{"X":1422,"KEGG":"R01580","RHEA_ID":15880,"DIRECTION":"BI","MASTER_ID":15877,"ecocyc":"PYRDAMPTRANS-RXN","metacyc":"PYRDAMPTRANS-RXN","compounds":"2-oxoglutarate + pyridoxamine 5'-phosphate <=> D-glutamate + pyridoxal 5'-phosphate","pmd":1.032}
{"X":1423,"KEGG":"R01581","RHEA_ID":12836,"DIRECTION":"BI","MASTER_ID":12833,"compounds":"an N-acyl-D-glutamate + H2O <=> a carboxylate + D-glutamate"}
{"X":1424,"KEGG":"R01583","RHEA_ID":22363,"DIRECTION":"BI","MASTER_ID":22360,"metacyc":"D-GLUTAMATE-CYCLASE-RXN","compounds":"D-glutamate <=> 5-oxo-D-proline + H2O","pmd":18.011}
{"X":1425,"KEGG":"R01584","RHEA_ID":21771,"DIRECTION":"BI","MASTER_ID":21768,"metacyc":"N-METHYLALANINE-DEHYDROGENASE-RXN","compounds":"H2O + N-methyl-L-alanine + NADP(+) <=> H(+) + methylamine + NADPH + pyruvate","pmd":642.028}
{"X":1426,"KEGG":"R01585","RHEA_ID":17120,"DIRECTION":"BI","MASTER_ID":17117,"compounds":"ATP + L-glutamate + methylamine <=> ADP + H(+) + N(5)-methyl-L-glutamine + phosphate","pmd":13.032}
{"X":1427,"KEGG":"R01585","RHEA_ID":17120,"DIRECTION":"BI","MASTER_ID":17117,"compounds":"ATP + L-glutamate + methylamine <=> ADP + H(+) + N(5)-methyl-L-glutamine + phosphate","pmd":79.966}
{"X":1428,"KEGG":"R01586","RHEA_ID":15840,"DIRECTION":"BI","MASTER_ID":15837,"compounds":"L-glutamate + methylamine <=> N-methyl-L-glutamate + NH4(+)","pmd":14.016}
{"X":1429,"KEGG":"R01587","RHEA_ID":24111,"DIRECTION":"BI","MASTER_ID":24108,"compounds":"H2O + N-methyl-2-oxoglutaramate <=> 2-oxoglutarate + methylamine","pmd":13.032}
{"X":1430,"KEGG":"R01588","RHEA_ID":10207,"DIRECTION":"BI","MASTER_ID":10204,"metacyc":"1.5.8.1-RXN","compounds":"dimethylamine + H(+) + H2O + oxidized [electron-transfer flavoprotein] <=> formaldehyde + methylamine + reduced [electron-transfer flavoprotein]"}
{"X":1431,"KEGG":"R01589","RHEA_ID":11767,"DIRECTION":"BI","MASTER_ID":11764,"compounds":"H2O + methylguanidine <=> methylamine + urea"}
{"X":1432,"KEGG":"R01593","RHEA_ID":16872,"DIRECTION":"BI","MASTER_ID":16869,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate","pmd":31.99}
{"X":1433,"KEGG":"R01594","RHEA_ID":14988,"DIRECTION":"BI","MASTER_ID":14985,"metacyc":"ARACHIDONATE-8-LIPOXYGENASE-RXN","compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate","pmd":31.99}
{"X":1434,"KEGG":"R01595","RHEA_ID":17488,"DIRECTION":"BI","MASTER_ID":17485,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate","pmd":31.99}
{"X":1435,"KEGG":"R01596","RHEA_ID":10431,"DIRECTION":"BI","MASTER_ID":10428,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate","pmd":31.99}
{"X":1436,"KEGG":"R01598","RHEA_ID":19716,"DIRECTION":"BI","MASTER_ID":19713,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA <=> (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate","pmd":42.823}
{"X":1437,"KEGG":"R01598","RHEA_ID":19716,"DIRECTION":"BI","MASTER_ID":19713,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA <=> (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate","pmd":420.052}
{"X":1438,"KEGG":"R01598","RHEA_ID":19716,"DIRECTION":"BI","MASTER_ID":19713,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA <=> (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate","pmd":159.933}
{"X":1439,"KEGG":"R01599","RHEA_ID":23731,"DIRECTION":"BI","MASTER_ID":23728,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 <=> A + H2O + prostaglandin H2","pmd":47.985}
{"X":1440,"KEGG":"R01602","RHEA_ID":10267,"DIRECTION":"BI","MASTER_ID":10264,"ecocyc":"ALDOSE-1-EPIMERASE-RXN","metacyc":"ALDOSE-1-EPIMERASE-RXN","compounds":"alpha-D-glucose <=> beta-D-glucose","pmd":0}
{"X":1441,"KEGG":"R01604","RHEA_ID":20048,"DIRECTION":"BI","MASTER_ID":20045,"compounds":"3-oxopropanoate + H2O + NAD(+) <=> 2 H(+) + malonate + NADH","pmd":560.106}
{"X":1442,"KEGG":"R01607","RHEA_ID":20044,"DIRECTION":"BI","MASTER_ID":20041,"compounds":"3-oxopropanoate + H2O + NADP(+) <=> 2 H(+) + malonate + NADPH","pmd":640.072}
{"X":1443,"KEGG":"R01608","RHEA_ID":13360,"DIRECTION":"BI","MASTER_ID":13357,"compounds":"3-hydroxypropanoate + NAD(+) <=> 3-oxopropanoate + H(+) + NADH"}
{"X":1444,"KEGG":"R01609","RHEA_ID":22375,"DIRECTION":"BI","MASTER_ID":22372,"compounds":"H2O + O2 + propionate 3-nitronate <=> 3-oxopropanoate + H(+) + H2O2 + nitrite"}
{"X":1445,"KEGG":"R01611","RHEA_ID":17960,"DIRECTION":"BI","MASTER_ID":17957,"compounds":"3-oxopropanoate <=> H2O + propynoate"}
{"X":1446,"KEGG":"R01613","RHEA_ID":11131,"DIRECTION":"BI","MASTER_ID":11128,"compounds":"4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA <=> 2',4,4',6'-tetrahydroxychalcone + 3 CO2 + 4 CoA","pmd":146.037}
{"X":1447,"KEGG":"R01613","RHEA_ID":11131,"DIRECTION":"BI","MASTER_ID":11128,"compounds":"4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA <=> 2',4,4',6'-tetrahydroxychalcone + 3 CO2 + 4 CoA","pmd":86}
{"X":1448,"KEGG":"R01614","RHEA_ID":11939,"DIRECTION":"BI","MASTER_ID":11936,"compounds":"4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4 CO2 + 4 CoA + trans-resveratrol","pmd":146.037}
{"X":1449,"KEGG":"R01614","RHEA_ID":11939,"DIRECTION":"BI","MASTER_ID":11936,"compounds":"4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4 CO2 + 4 CoA + trans-resveratrol","pmd":86}
{"X":1450,"KEGG":"R01616","RHEA_ID":19644,"DIRECTION":"BI","MASTER_ID":19641,"compounds":"4-coumarate + ATP + CoA <=> 4-coumaroyl-CoA + AMP + diphosphate","pmd":159.933}
{"X":1451,"KEGG":"R01616","RHEA_ID":19644,"DIRECTION":"BI","MASTER_ID":19641,"compounds":"4-coumarate + ATP + CoA <=> 4-coumaroyl-CoA + AMP + diphosphate","pmd":183.016}
{"X":1452,"KEGG":"R01616","RHEA_ID":19644,"DIRECTION":"BI","MASTER_ID":19641,"compounds":"4-coumarate + ATP + CoA <=> 4-coumaroyl-CoA + AMP + diphosphate","pmd":146.037}
{"X":1453,"KEGG":"R01617","RHEA_ID":13408,"DIRECTION":"BI","MASTER_ID":13405,"compounds":"4-coumaroyl-CoA + agmatine <=> CoA + H(+) + N-(4-guanidinobutyl)-4-hydroxycinnamamide","pmd":146.037}
{"X":1454,"KEGG":"R01619","RHEA_ID":19200,"DIRECTION":"BI","MASTER_ID":19197,"compounds":"adenosine 5'-phosphosulfate + NH4(+) <=> adenosine 5'-phosphoramidate + 2 H(+) + sulfate","pmd":80.941}
{"X":1455,"KEGG":"R01620","RHEA_ID":14420,"DIRECTION":"BI","MASTER_ID":14417,"metacyc":"LYSINE-N-ACETYLTRANSFERASE-RXN","compounds":"acetyl phosphate + L-lysine <=> H(+) + N(6)-acetyl-L-lysine + phosphate","pmd":48.129}
{"X":1456,"KEGG":"R01620","RHEA_ID":14420,"DIRECTION":"BI","MASTER_ID":14417,"metacyc":"LYSINE-N-ACETYLTRANSFERASE-RXN","compounds":"acetyl phosphate + L-lysine <=> H(+) + N(6)-acetyl-L-lysine + phosphate","pmd":42.011}
{"X":1457,"KEGG":"R01621","RHEA_ID":10471,"DIRECTION":"BI","MASTER_ID":10468,"compounds":"D-xylulose 5-phosphate + phosphate <=> acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O","pmd":60.021}
{"X":1458,"KEGG":"R01623","RHEA_ID":20540,"DIRECTION":"BI","MASTER_ID":20537,"compounds":"H2O + holo-[ACP] <=> apo-[ACP] + D-pantetheine 4'-phosphate + H(+)"}
{"X":1459,"KEGG":"R01624","RHEA_ID":41791,"DIRECTION":"BI","MASTER_ID":41788,"ecocyc":"ACP-S-ACETYLTRANSFER-RXN","metacyc":"ACP-S-ACETYLTRANSFER-RXN","compounds":"acetyl-CoA + holo-[ACP] <=> acetyl-[ACP] + CoA","pmd":42.011}
{"X":1460,"KEGG":"R01625","RHEA_ID":12071,"DIRECTION":"BI","MASTER_ID":12068,"compounds":"apo-[ACP] + CoA <=> adenosine 3',5'-bisphosphate + H(+) + holo-[ACP]","pmd":340.086}
{"X":1461,"KEGG":"R01626","RHEA_ID":41795,"DIRECTION":"BI","MASTER_ID":41792,"ecocyc":"MALONYL-COA-ACP-TRANSACYL-RXN","metacyc":"MALONYL-COA-ACP-TRANSACYL-RXN","compounds":"holo-[ACP] + malonyl-CoA <=> CoA + malonyl-[ACP]","pmd":86}
{"X":1462,"KEGG":"R01627","RHEA_ID":24851,"DIRECTION":"BI","MASTER_ID":24848,"compounds":"3-dehydroshikimate <=> 3,4-dihydroxybenzoate + H2O","pmd":18.011}
{"X":1463,"KEGG":"R01628","RHEA_ID":11483,"DIRECTION":"BI","MASTER_ID":11480,"compounds":"3-hydroxybenzoate + H(+) + NADPH + O2 <=> 3,4-dihydroxybenzoate + H2O + NADP(+)","pmd":15.995}
{"X":1464,"KEGG":"R01628","RHEA_ID":11483,"DIRECTION":"BI","MASTER_ID":11480,"compounds":"3-hydroxybenzoate + H(+) + NADPH + O2 <=> 3,4-dihydroxybenzoate + H2O + NADP(+)","pmd":591.064}
{"X":1465,"KEGG":"R01629","RHEA_ID":30038,"DIRECTION":"BI","MASTER_ID":30035,"compounds":"3,4-dihydroxybenzoate + 2 H(+) + NADH + O2 <=> benzene-1,2,4-triol + CO2 + H2O + NAD(+)","pmd":539.093}
{"X":1466,"KEGG":"R01629","RHEA_ID":30038,"DIRECTION":"BI","MASTER_ID":30035,"compounds":"3,4-dihydroxybenzoate + 2 H(+) + NADH + O2 <=> benzene-1,2,4-triol + CO2 + H2O + NAD(+)","pmd":27.995}
{"X":1467,"KEGG":"R01630","RHEA_ID":30042,"DIRECTION":"BI","MASTER_ID":30039,"compounds":"3,4-dihydroxybenzoate + 2 H(+) + NADPH + O2 <=> benzene-1,2,4-triol + CO2 + H2O + NADP(+)","pmd":27.995}
{"X":1468,"KEGG":"R01630","RHEA_ID":30042,"DIRECTION":"BI","MASTER_ID":30039,"compounds":"3,4-dihydroxybenzoate + 2 H(+) + NADPH + O2 <=> benzene-1,2,4-triol + CO2 + H2O + NADP(+)","pmd":619.059}
{"X":1469,"KEGG":"R01631","RHEA_ID":10087,"DIRECTION":"BI","MASTER_ID":10084,"compounds":"3,4-dihydroxybenzoate + O2 <=> 3-carboxy-cis,cis-muconate + 2 H(+)","pmd":31.99}
{"X":1470,"KEGG":"R01632","RHEA_ID":24047,"DIRECTION":"BI","MASTER_ID":24044,"compounds":"3,4-dihydroxybenzoate + O2 <=> 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)","pmd":31.99}
{"X":1471,"KEGG":"R01633","RHEA_ID":10747,"DIRECTION":"BI","MASTER_ID":10744,"metacyc":"1.3.1.53-RXN","compounds":"(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+) <=> 3,4-dihydroxybenzoate + CO2 + NADH","pmd":46.006}
{"X":1472,"KEGG":"R01633","RHEA_ID":10747,"DIRECTION":"BI","MASTER_ID":10744,"metacyc":"1.3.1.53-RXN","compounds":"(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+) <=> 3,4-dihydroxybenzoate + CO2 + NADH","pmd":510.09}
{"X":1473,"KEGG":"R01634","RHEA_ID":18604,"DIRECTION":"BI","MASTER_ID":18601,"compounds":"3,4-dihydroxyphthalate + H(+) <=> 3,4-dihydroxybenzoate + CO2","pmd":43.99}
{"X":1474,"KEGG":"R01635","RHEA_ID":24187,"DIRECTION":"BI","MASTER_ID":24184,"metacyc":"45-DIHYDROXYPHTHALATE-DECARBOXYLASE-RXN","compounds":"4,5-dihydroxyphthalate + H(+) <=> 3,4-dihydroxybenzoate + CO2","pmd":43.99}
{"X":1475,"KEGG":"R01636","RHEA_ID":13940,"DIRECTION":"BI","MASTER_ID":13937,"compounds":"4-sulfobenzoate + NADH + O2 <=> 3,4-dihydroxybenzoate + NAD(+) + sulfite","pmd":47.967}
{"X":1476,"KEGG":"R01636","RHEA_ID":13940,"DIRECTION":"BI","MASTER_ID":13937,"compounds":"4-sulfobenzoate + NADH + O2 <=> 3,4-dihydroxybenzoate + NAD(+) + sulfite","pmd":511.098}
{"X":1477,"KEGG":"R01639","RHEA_ID":10967,"DIRECTION":"BI","MASTER_ID":10964,"compounds":"ATP + D-xylulose <=> ADP + D-xylulose 5-phosphate + H(+)","pmd":79.966}
{"X":1478,"KEGG":"R01641","RHEA_ID":10511,"DIRECTION":"BI","MASTER_ID":10508,"ecocyc":"1TRANSKETO-RXN","metacyc":"1TRANSKETO-RXN","compounds":"D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate <=> aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate","pmd":60.021}
{"X":1479,"KEGG":"R01644","RHEA_ID":23951,"DIRECTION":"BI","MASTER_ID":23948,"compounds":"4-hydroxybutanoate + NAD(+) <=> H(+) + NADH + succinate semialdehyde","pmd":562.085}
{"X":1480,"KEGG":"R01644","RHEA_ID":23951,"DIRECTION":"BI","MASTER_ID":23948,"compounds":"4-hydroxybutanoate + NAD(+) <=> H(+) + NADH + succinate semialdehyde","pmd":2.016}
{"X":1481,"KEGG":"R01647","RHEA_ID":25791,"DIRECTION":"BI","MASTER_ID":25788,"compounds":"4-hydroxy-2-oxoheptanedioate <=> pyruvate + succinate semialdehyde","pmd":88.016}
{"X":1482,"KEGG":"R01648","RHEA_ID":23355,"DIRECTION":"BI","MASTER_ID":23352,"ecocyc":"GABATRANSAM-RXN","metacyc":"GABATRANSAM-RXN","compounds":"2-oxoglutarate + 4-aminobutanoate <=> L-glutamate + succinate semialdehyde","pmd":1.032}
{"X":1483,"KEGG":"R01649","RHEA_ID":10435,"DIRECTION":"BI","MASTER_ID":10432,"compounds":"2-(acetamidomethylene)succinate + H(+) + 2 H2O <=> acetate + CO2 + NH4(+) + succinate semialdehyde","pmd":85.016}
{"X":1484,"KEGG":"R01651","RHEA_ID":25180,"DIRECTION":"BI","MASTER_ID":25177,"compounds":"4-methyl-2-oxopentanoate + CoA + NAD(+) <=> 3-methylbutanoyl-CoA + CO2 + NADH","pmd":84.058}
{"X":1485,"KEGG":"R01651","RHEA_ID":25180,"DIRECTION":"BI","MASTER_ID":25177,"compounds":"4-methyl-2-oxopentanoate + CoA + NAD(+) <=> 3-methylbutanoyl-CoA + CO2 + NADH","pmd":187.056}
{"X":1486,"KEGG":"R01651","RHEA_ID":25180,"DIRECTION":"BI","MASTER_ID":25177,"compounds":"4-methyl-2-oxopentanoate + CoA + NAD(+) <=> 3-methylbutanoyl-CoA + CO2 + NADH","pmd":535.062}
{"X":1487,"KEGG":"R01652","RHEA_ID":25081,"DIRECTION":"BI","MASTER_ID":25078,"compounds":"(2S)-2-isopropyl-3-oxosuccinate + H(+) <=> 4-methyl-2-oxopentanoate + CO2","pmd":43.99}
{"X":1488,"KEGG":"R01655","RHEA_ID":23703,"DIRECTION":"BI","MASTER_ID":23700,"ecocyc":"METHENYLTHFCYCLOHYDRO-RXN","metacyc":"METHENYLTHFCYCLOHYDRO-RXN","compounds":"5,10-methenyltetrahydrofolate + H2O <=> (6S)-10-formyltetrahydrofolate + H(+)","pmd":17.003}
{"X":1489,"KEGG":"R01657","RHEA_ID":14176,"DIRECTION":"BI","MASTER_ID":14173,"compounds":"dimethylallyl diphosphate + L-tryptophan <=> 4-(3-methylbut-2-enyl)-L-tryptophan + diphosphate","pmd":26.147}
{"X":1490,"KEGG":"R01657","RHEA_ID":14176,"DIRECTION":"BI","MASTER_ID":14173,"compounds":"dimethylallyl diphosphate + L-tryptophan <=> 4-(3-methylbut-2-enyl)-L-tryptophan + diphosphate","pmd":68.063}
{"X":1491,"KEGG":"R01658","RHEA_ID":22411,"DIRECTION":"BI","MASTER_ID":22408,"compounds":"dimethylallyl diphosphate + isopentenyl diphosphate <=> (2E)-geranyl diphosphate + diphosphate","pmd":68.063}
{"X":1492,"KEGG":"R01659","RHEA_ID":11331,"DIRECTION":"BI","MASTER_ID":11328,"compounds":"dimethylallyl diphosphate + isopentenyl diphosphate <=> diphosphate + neryl diphosphate","pmd":68.063}
{"X":1493,"KEGG":"R01660","RHEA_ID":16772,"DIRECTION":"BI","MASTER_ID":16769,"metacyc":"GLUCOSE-16-BISPHOSPHATE-SYNTHASE-RXN","compounds":"(2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 1-phosphate <=> (2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+)","pmd":74.037}
{"X":1494,"KEGG":"R01662","RHEA_ID":17768,"DIRECTION":"BI","MASTER_ID":17765,"compounds":"(2R)-3-phospho-glyceroyl phosphate <=> (2R)-2,3-bisphosphoglycerate + H(+)","pmd":0}
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{"X":1496,"KEGG":"R01664","RHEA_ID":29366,"DIRECTION":"BI","MASTER_ID":29363,"compounds":"dCMP + H2O <=> 2'-deoxycytidine + phosphate","pmd":79.966}
{"X":1497,"KEGG":"R01665","RHEA_ID":25097,"DIRECTION":"BI","MASTER_ID":25094,"compounds":"ATP + dCMP <=> ADP + dCDP","pmd":79.966}
{"X":1498,"KEGG":"R01666","RHEA_ID":46043,"DIRECTION":"BI","MASTER_ID":46040,"metacyc":"RXN-14093","compounds":"2'-deoxycytidine + ATP <=> ADP + dCMP + H(+)","pmd":79.966}
{"X":1499,"KEGG":"R01668","RHEA_ID":22639,"DIRECTION":"BI","MASTER_ID":22636,"compounds":"dCTP + H2O <=> dCMP + diphosphate + H(+)","pmd":159.933}
{"X":1500,"KEGG":"R01669","RHEA_ID":11283,"DIRECTION":"BI","MASTER_ID":11280,"metacyc":"2.1.2.8-RXN","compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dCMP","pmd":12}
{"X":1501,"KEGG":"R01669","RHEA_ID":11283,"DIRECTION":"BI","MASTER_ID":11280,"metacyc":"2.1.2.8-RXN","compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dCMP","pmd":30.011}
{"X":1502,"KEGG":"R01670","RHEA_ID":11571,"DIRECTION":"BI","MASTER_ID":11568,"compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP <=> 5-methyldeoxycytidine 5'-phosphate + 7,8-dihydrofolate","pmd":14.016}
{"X":1503,"KEGG":"R01676","RHEA_ID":14668,"DIRECTION":"BI","MASTER_ID":14665,"compounds":"guanine + H(+) + H2O <=> NH4(+) + xanthine","pmd":0.984}
{"X":1504,"KEGG":"R01677","RHEA_ID":30774,"DIRECTION":"BI","MASTER_ID":30771,"compounds":"guanosine + H2O <=> D-ribose + guanine","pmd":132.042}
{"X":1505,"KEGG":"R01681","RHEA_ID":17388,"DIRECTION":"BI","MASTER_ID":17385,"compounds":"H2O + hypotaurine + NAD(+) <=> H(+) + NADH + taurine","pmd":539.102}
{"X":1506,"KEGG":"R01681","RHEA_ID":17388,"DIRECTION":"BI","MASTER_ID":17385,"compounds":"H2O + hypotaurine + NAD(+) <=> H(+) + NADH + taurine","pmd":15.995}
{"X":1507,"KEGG":"R01682","RHEA_ID":25224,"DIRECTION":"BI","MASTER_ID":25221,"compounds":"H(+) + L-cysteate <=> CO2 + taurine","pmd":43.99}
{"X":1508,"KEGG":"R01683","RHEA_ID":12583,"DIRECTION":"BI","MASTER_ID":12580,"compounds":"H2O + NAD(+) + tauropine <=> H(+) + NADH + pyruvate + taurine","pmd":72.021}
{"X":1509,"KEGG":"R01683","RHEA_ID":12583,"DIRECTION":"BI","MASTER_ID":12580,"compounds":"H2O + NAD(+) + tauropine <=> H(+) + NADH + pyruvate + taurine","pmd":539.102}
{"X":1510,"KEGG":"R01684","RHEA_ID":16356,"DIRECTION":"BI","MASTER_ID":16353,"metacyc":"RXN-2301","compounds":"2-oxoglutarate + taurine <=> L-glutamate + sulfoacetaldehyde","pmd":1.032}
{"X":1511,"KEGG":"R01688","RHEA_ID":13588,"DIRECTION":"BI","MASTER_ID":13585,"metacyc":"BUTYRATE-KINASE-RXN","compounds":"ATP + butanoate <=> ADP + butanoyl phosphate","pmd":79.966}
{"X":1512,"KEGG":"R01689","RHEA_ID":10203,"DIRECTION":"BI","MASTER_ID":10200,"metacyc":"2-ENOATE-REDUCTASE-RXN","compounds":"butanoate + NAD(+) <=> (2E)-2-butenoate + H(+) + NADH"}
{"X":1513,"KEGG":"R01694","RHEA_ID":15004,"DIRECTION":"BI","MASTER_ID":15001,"compounds":"keto-L-sorbose + NADP(+) <=> 5-dehydro-D-fructose + H(+) + NADPH","pmd":566.036}
{"X":1514,"KEGG":"R01694","RHEA_ID":15004,"DIRECTION":"BI","MASTER_ID":15001,"compounds":"keto-L-sorbose + NADP(+) <=> 5-dehydro-D-fructose + H(+) + NADPH","pmd":2.016}
{"X":1515,"KEGG":"R01695","RHEA_ID":17856,"DIRECTION":"BI","MASTER_ID":17853,"compounds":"keto-L-sorbose + O2 <=> 5-dehydro-D-fructose + H2O2","pmd":2.016}
{"X":1516,"KEGG":"R01696","RHEA_ID":14716,"DIRECTION":"BI","MASTER_ID":14713,"compounds":"A + keto-L-sorbose <=> 5-dehydro-D-fructose + AH2","pmd":2.016}
{"X":1517,"KEGG":"R01697","RHEA_ID":21323,"DIRECTION":"BI","MASTER_ID":21320,"compounds":"A + D-sorbitol <=> AH2 + keto-L-sorbose","pmd":2.016}
{"X":1518,"KEGG":"R01698","RHEA_ID":33062,"DIRECTION":"BI","MASTER_ID":33059,"metacyc":"DIHYDLIPOXN-RXN","compounds":"(R)-dihydrolipoamide + NAD(+) <=> (R)-lipoamide + H(+) + NADH","pmd":459.057}
{"X":1519,"KEGG":"R01698","RHEA_ID":33062,"DIRECTION":"BI","MASTER_ID":33059,"metacyc":"DIHYDLIPOXN-RXN","compounds":"(R)-dihydrolipoamide + NAD(+) <=> (R)-lipoamide + H(+) + NADH","pmd":2.016}
{"X":1520,"KEGG":"R01699","RHEA_ID":19192,"DIRECTION":"BI","MASTER_ID":19189,"metacyc":"RXN0-1134","compounds":"[dihydrolipoyllysine-residue acetyltransferase]-(R)-N(6)-lipoyl-L-lysine + H(+) + pyruvate <=> [dihydrolipoyllysine-residue acetyltransferase]-(R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysine + CO2"}
{"X":1521,"KEGG":"R01701","RHEA_ID":13460,"DIRECTION":"BI","MASTER_ID":13457,"metacyc":"1.2.4.4-RXN","compounds":"3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]-(R)-N(6)-lipoyl-L-lysine + H(+) <=> [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]-(R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysine + CO2"}
{"X":1522,"KEGG":"R01703","RHEA_ID":23963,"DIRECTION":"BI","MASTER_ID":23960,"compounds":"H(+) + 2 H2O2 + hexadecanoate <=> CO2 + 3 H2O + pentadecanal","pmd":30.011}
{"X":1523,"KEGG":"R01705","RHEA_ID":19236,"DIRECTION":"BI","MASTER_ID":19233,"compounds":"H2O + S-hexadecanoyl-L-cysteinyl-[protein] <=> H(+) + hexadecanoate + L-cysteinyl-[protein]"}
{"X":1524,"KEGG":"R01706","RHEA_ID":41935,"DIRECTION":"BI","MASTER_ID":41932,"compounds":"H2O + hexadecanoyl-[ACP] <=> H(+) + hexadecanoate + holo-[ACP]"}
{"X":1525,"KEGG":"R01707","RHEA_ID":21339,"DIRECTION":"BI","MASTER_ID":21336,"compounds":"NAD(+) + pyridoxal <=> 4-pyridoxolactone + H(+) + NADH","pmd":499.074}
{"X":1526,"KEGG":"R01707","RHEA_ID":21339,"DIRECTION":"BI","MASTER_ID":21336,"compounds":"NAD(+) + pyridoxal <=> 4-pyridoxolactone + H(+) + NADH","pmd":2.016}
{"X":1527,"KEGG":"R01708","RHEA_ID":16132,"DIRECTION":"BI","MASTER_ID":16129,"metacyc":"PYRIDOXINE-4-DEHYDROGENASE-RXN","compounds":"NADP(+) + pyridoxine <=> H(+) + NADPH + pyridoxal","pmd":577.025}
{"X":1528,"KEGG":"R01708","RHEA_ID":16132,"DIRECTION":"BI","MASTER_ID":16129,"metacyc":"PYRIDOXINE-4-DEHYDROGENASE-RXN","compounds":"NADP(+) + pyridoxine <=> H(+) + NADPH + pyridoxal","pmd":2.016}
{"X":1529,"KEGG":"R01709","RHEA_ID":23727,"DIRECTION":"BI","MASTER_ID":23724,"compounds":"H2O + O2 + pyridoxal <=> 4-pyridoxate + H(+) + H2O2","pmd":15.995}
{"X":1530,"KEGG":"R01710","RHEA_ID":30778,"DIRECTION":"BI","MASTER_ID":30775,"compounds":"H2O + O2 + pyridoxamine <=> H2O2 + NH4(+) + pyridoxal","pmd":1.032}
{"X":1531,"KEGG":"R01711","RHEA_ID":15036,"DIRECTION":"BI","MASTER_ID":15033,"compounds":"O2 + pyridoxine <=> H2O2 + pyridoxal","pmd":2.016}
{"X":1532,"KEGG":"R01712","RHEA_ID":12844,"DIRECTION":"BI","MASTER_ID":12841,"metacyc":"2.6.1.30-RXN","compounds":"pyridoxamine + pyruvate <=> L-alanine + pyridoxal","pmd":1.032}
{"X":1533,"KEGG":"R01713","RHEA_ID":10847,"DIRECTION":"BI","MASTER_ID":10844,"ecocyc":"PYROXALTRANSAM-RXN","metacyc":"PYROXALTRANSAM-RXN","compounds":"oxaloacetate + pyridoxamine <=> L-aspartate + pyridoxal","pmd":1.032}
{"X":1534,"KEGG":"R01714","RHEA_ID":21023,"DIRECTION":"BI","MASTER_ID":21020,"compounds":"5-O-(1-carboxyvinyl)-3-phosphoshikimate <=> chorismate + phosphate","pmd":97.977}
{"X":1535,"KEGG":"R01715","RHEA_ID":13900,"DIRECTION":"BI","MASTER_ID":13897,"metacyc":"CHORISMATEMUT-RXN","compounds":"chorismate <=> prephenate","pmd":0}
{"X":1536,"KEGG":"R01716","RHEA_ID":11675,"DIRECTION":"BI","MASTER_ID":11672,"ecocyc":"PABASYN-RXN","metacyc":"PABASYN-RXN","compounds":"chorismate + L-glutamine <=> 4-amino-4-deoxychorismate + L-glutamate","pmd":0.984}
{"X":1537,"KEGG":"R01717","RHEA_ID":18988,"DIRECTION":"BI","MASTER_ID":18985,"ecocyc":"ISOCHORSYN-RXN","metacyc":"ISOCHORSYN-RXN","compounds":"chorismate <=> isochorismate","pmd":0}
{"X":1538,"KEGG":"R01720","RHEA_ID":12239,"DIRECTION":"BI","MASTER_ID":12236,"compounds":"H2O + NADP(+) + nicotinate <=> 6-hydroxynicotinate + H(+) + NADPH","pmd":605.056}
{"X":1539,"KEGG":"R01720","RHEA_ID":12239,"DIRECTION":"BI","MASTER_ID":12236,"compounds":"H2O + NADP(+) + nicotinate <=> 6-hydroxynicotinate + H(+) + NADPH","pmd":15.995}
{"X":1540,"KEGG":"R01721","RHEA_ID":20244,"DIRECTION":"BI","MASTER_ID":20241,"compounds":"nicotinate + S-adenosyl-L-methionine <=> N-methylnicotinate + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":1541,"KEGG":"R01722","RHEA_ID":19440,"DIRECTION":"BI","MASTER_ID":19437,"metacyc":"NICOTINATE-GLUCOSYLTRANSFERASE-RXN","compounds":"nicotinate + UDP-alpha-D-glucose <=> N-(beta-D-glucosyl)nicotinate + UDP","pmd":163.061}
{"X":1542,"KEGG":"R01722","RHEA_ID":19440,"DIRECTION":"BI","MASTER_ID":19437,"metacyc":"NICOTINATE-GLUCOSYLTRANSFERASE-RXN","compounds":"nicotinate + UDP-alpha-D-glucose <=> N-(beta-D-glucosyl)nicotinate + UDP","pmd":162.053}
{"X":1543,"KEGG":"R01724","RHEA_ID":13396,"DIRECTION":"BI","MASTER_ID":13393,"compounds":"diphosphate + nicotinate beta-D-ribonucleotide <=> 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinate","pmd":53.903}
{"X":1544,"KEGG":"R01724","RHEA_ID":13396,"DIRECTION":"BI","MASTER_ID":13393,"compounds":"diphosphate + nicotinate beta-D-ribonucleotide <=> 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinate","pmd":37.078}
{"X":1545,"KEGG":"R01724","RHEA_ID":36166,"DIRECTION":"BI","MASTER_ID":36163,"compounds":"5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate <=> ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate","pmd":53.903}
{"X":1546,"KEGG":"R01724","RHEA_ID":36166,"DIRECTION":"BI","MASTER_ID":36163,"compounds":"5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate <=> ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate","pmd":37.078}
{"X":1547,"KEGG":"R01728","RHEA_ID":13872,"DIRECTION":"BI","MASTER_ID":13869,"compounds":"NAD(+) + prephenate <=> 3-(4-hydroxyphenyl)pyruvate + CO2 + NADH","pmd":484.075}
{"X":1548,"KEGG":"R01728","RHEA_ID":13872,"DIRECTION":"BI","MASTER_ID":13869,"compounds":"NAD(+) + prephenate <=> 3-(4-hydroxyphenyl)pyruvate + CO2 + NADH","pmd":46.005}
{"X":1549,"KEGG":"R01730","RHEA_ID":21643,"DIRECTION":"BI","MASTER_ID":21640,"metacyc":"PREPHENATE-DEHYDROGENASE-NADP%2b-RXN","compounds":"NADP(+) + prephenate <=> 3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH","pmd":46.005}
{"X":1550,"KEGG":"R01730","RHEA_ID":21643,"DIRECTION":"BI","MASTER_ID":21640,"metacyc":"PREPHENATE-DEHYDROGENASE-NADP%2b-RXN","compounds":"NADP(+) + prephenate <=> 3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH","pmd":564.041}
{"X":1551,"KEGG":"R01731","RHEA_ID":20448,"DIRECTION":"BI","MASTER_ID":20445,"metacyc":"PREPHENATE-ASP-TRANSAMINE-RXN","compounds":"L-arogenate + oxaloacetate <=> L-aspartate + prephenate","pmd":1.032}
{"X":1552,"KEGG":"R01732","RHEA_ID":11411,"DIRECTION":"BI","MASTER_ID":11408,"compounds":"H(+) + H2O + riboflavin <=> lumichrome + ribitol","pmd":134.058}
{"X":1553,"KEGG":"R01736","RHEA_ID":25248,"DIRECTION":"BI","MASTER_ID":25245,"compounds":"(R)-S-lactoylglutathione + H2O <=> (R)-lactate + glutathione + H(+)","pmd":72.021}
{"X":1554,"KEGG":"R01737","RHEA_ID":19436,"DIRECTION":"BI","MASTER_ID":19433,"compounds":"ATP + D-gluconate <=> 6-phospho-D-gluconate + ADP + H(+)","pmd":79.966}
{"X":1555,"KEGG":"R01738","RHEA_ID":23943,"DIRECTION":"BI","MASTER_ID":23940,"compounds":"D-gluconate + NAD(+) <=> 5-dehydro-D-gluconate + H(+) + NADH","pmd":470.074}
{"X":1556,"KEGG":"R01738","RHEA_ID":23943,"DIRECTION":"BI","MASTER_ID":23940,"compounds":"D-gluconate + NAD(+) <=> 5-dehydro-D-gluconate + H(+) + NADH","pmd":2.016}
{"X":1557,"KEGG":"R01739","RHEA_ID":16656,"DIRECTION":"BI","MASTER_ID":16653,"ecocyc":"1.1.1.215-RXN","metacyc":"1.1.1.215-RXN","compounds":"D-gluconate + NADP(+) <=> 2-dehydro-D-gluconate + H(+) + NADPH","pmd":2.016}
{"X":1558,"KEGG":"R01739","RHEA_ID":16656,"DIRECTION":"BI","MASTER_ID":16653,"ecocyc":"1.1.1.215-RXN","metacyc":"1.1.1.215-RXN","compounds":"D-gluconate + NADP(+) <=> 2-dehydro-D-gluconate + H(+) + NADPH","pmd":550.041}
{"X":1559,"KEGG":"R01740","RHEA_ID":23939,"DIRECTION":"BI","MASTER_ID":23936,"compounds":"D-gluconate + NADP(+) <=> 5-dehydro-D-gluconate + H(+) + NADPH","pmd":550.041}
{"X":1560,"KEGG":"R01740","RHEA_ID":23939,"DIRECTION":"BI","MASTER_ID":23936,"compounds":"D-gluconate + NADP(+) <=> 5-dehydro-D-gluconate + H(+) + NADPH","pmd":2.016}
{"X":1561,"KEGG":"R01741","RHEA_ID":30782,"DIRECTION":"BI","MASTER_ID":30779,"compounds":"D-gluconate + FAD + H(+) <=> 2-dehydro-D-gluconate + FADH2","pmd":2.016}
{"X":1562,"KEGG":"R01742","RHEA_ID":12772,"DIRECTION":"BI","MASTER_ID":12769,"compounds":"A + D-gluconate <=> 2-dehydro-D-gluconate + AH2","pmd":2.016}
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{"X":1564,"KEGG":"R01745","RHEA_ID":18848,"DIRECTION":"BI","MASTER_ID":18845,"ecocyc":"RXN0-5289","metacyc":"RXN0-5289","compounds":"(R)-glycerate + NAD(+) <=> 2-hydroxy-3-oxopropanoate + H(+) + NADH","pmd":560.106}
{"X":1565,"KEGG":"R01747","RHEA_ID":18844,"DIRECTION":"BI","MASTER_ID":18841,"compounds":"(R)-glycerate + NADP(+) <=> 2-hydroxy-3-oxopropanoate + H(+) + NADPH","pmd":2.016}
{"X":1566,"KEGG":"R01747","RHEA_ID":18844,"DIRECTION":"BI","MASTER_ID":18841,"compounds":"(R)-glycerate + NADP(+) <=> 2-hydroxy-3-oxopropanoate + H(+) + NADPH","pmd":640.072}
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{"X":1568,"KEGG":"R01749","RHEA_ID":13156,"DIRECTION":"BI","MASTER_ID":13153,"compounds":"(R)-glycerate + CO2 + NAD(+) <=> 2-hydroxy-3-oxosuccinate + 2 H(+) + NADH","pmd":516.116}
{"X":1569,"KEGG":"R01749","RHEA_ID":13156,"DIRECTION":"BI","MASTER_ID":13153,"compounds":"(R)-glycerate + CO2 + NAD(+) <=> 2-hydroxy-3-oxosuccinate + 2 H(+) + NADH","pmd":41.974}
{"X":1570,"KEGG":"R01750","RHEA_ID":13160,"DIRECTION":"BI","MASTER_ID":13157,"compounds":"(R)-glycerate + CO2 + NADP(+) <=> 2-hydroxy-3-oxosuccinate + 2 H(+) + NADPH","pmd":596.082}
{"X":1571,"KEGG":"R01750","RHEA_ID":13160,"DIRECTION":"BI","MASTER_ID":13157,"compounds":"(R)-glycerate + CO2 + NADP(+) <=> 2-hydroxy-3-oxosuccinate + 2 H(+) + NADPH","pmd":41.974}
{"X":1572,"KEGG":"R01751","RHEA_ID":13320,"DIRECTION":"BI","MASTER_ID":13317,"metacyc":"TARTRATE-DECARBOXYLASE-RXN","compounds":"(2R,3R)-tartrate + H(+) <=> (R)-glycerate + CO2","pmd":43.99}
{"X":1573,"KEGG":"R01752","RHEA_ID":30786,"DIRECTION":"BI","MASTER_ID":30783,"compounds":"D-glyceraldehyde + H2O + NAD(+) <=> (R)-glycerate + 2 H(+) + NADH","pmd":558.09}
{"X":1574,"KEGG":"R01754","RHEA_ID":20156,"DIRECTION":"BI","MASTER_ID":20153,"compounds":"ATP + L-arabinose <=> ADP + beta-L-arabinose 1-phosphate + H(+)","pmd":79.966}
{"X":1575,"KEGG":"R01757","RHEA_ID":17928,"DIRECTION":"BI","MASTER_ID":17925,"compounds":"L-arabinofuranose + NAD(+) <=> H(+) + L-arabinono-1,4-lactone + NADH","pmd":516.08}
{"X":1576,"KEGG":"R01757","RHEA_ID":17928,"DIRECTION":"BI","MASTER_ID":17925,"compounds":"L-arabinofuranose + NAD(+) <=> H(+) + L-arabinono-1,4-lactone + NADH","pmd":2.016}
{"X":1577,"KEGG":"R01758","RHEA_ID":25228,"DIRECTION":"BI","MASTER_ID":25225,"metacyc":"RXN-14102","compounds":"L-arabinitol + NAD(+) <=> H(+) + L-arabinose + NADH","pmd":2.016}
{"X":1578,"KEGG":"R01758","RHEA_ID":25228,"DIRECTION":"BI","MASTER_ID":25225,"metacyc":"RXN-14102","compounds":"L-arabinitol + NAD(+) <=> H(+) + L-arabinose + NADH","pmd":514.064}
{"X":1579,"KEGG":"R01758","RHEA_ID":25228,"DIRECTION":"BI","MASTER_ID":25225,"metacyc":"RXN-8772","compounds":"L-arabinitol + NAD(+) <=> H(+) + L-arabinose + NADH","pmd":2.016}
{"X":1580,"KEGG":"R01758","RHEA_ID":25228,"DIRECTION":"BI","MASTER_ID":25225,"metacyc":"RXN-8772","compounds":"L-arabinitol + NAD(+) <=> H(+) + L-arabinose + NADH","pmd":514.064}
{"X":1581,"KEGG":"R01759","RHEA_ID":25232,"DIRECTION":"BI","MASTER_ID":25229,"metacyc":"RXN-8772","compounds":"L-arabinitol + NADP(+) <=> H(+) + L-arabinose + NADPH","pmd":594.031}
{"X":1582,"KEGG":"R01759","RHEA_ID":25232,"DIRECTION":"BI","MASTER_ID":25229,"metacyc":"RXN-8772","compounds":"L-arabinitol + NADP(+) <=> H(+) + L-arabinose + NADPH","pmd":2.016}
{"X":1583,"KEGG":"R01761","RHEA_ID":14824,"DIRECTION":"BI","MASTER_ID":14821,"ecocyc":"ARABISOM-RXN","metacyc":"ARABISOM-RXN","compounds":"L-arabinose <=> L-ribulose","pmd":0}
{"X":1584,"KEGG":"R01764","RHEA_ID":23371,"DIRECTION":"BI","MASTER_ID":23368,"compounds":"H(+) + phenylglyoxylate <=> benzaldehyde + CO2","pmd":43.99}
{"X":1585,"KEGG":"R01766","RHEA_ID":21715,"DIRECTION":"BI","MASTER_ID":21712,"ecocyc":"PHENYLSERINE-ALDOLASE-RXN","metacyc":"PHENYLSERINE-ALDOLASE-RXN","compounds":"L-threo-3-phenylserine <=> benzaldehyde + glycine","pmd":75.032}
{"X":1586,"KEGG":"R01767","RHEA_ID":18316,"DIRECTION":"BI","MASTER_ID":18313,"compounds":"(R)-mandelonitrile <=> benzaldehyde + hydrogen cyanide","pmd":27.011}
{"X":1587,"KEGG":"R01768","RHEA_ID":24673,"DIRECTION":"BI","MASTER_ID":24670,"compounds":"H2O + hypoxanthine + NAD(+) <=> H(+) + NADH + xanthine","pmd":15.995}
{"X":1588,"KEGG":"R01768","RHEA_ID":24673,"DIRECTION":"BI","MASTER_ID":24670,"compounds":"H2O + hypoxanthine + NAD(+) <=> H(+) + NADH + xanthine","pmd":512.083}
{"X":1589,"KEGG":"R01770","RHEA_ID":16660,"DIRECTION":"BI","MASTER_ID":16657,"compounds":"H2O + inosine <=> D-ribose + hypoxanthine","pmd":118.028}
{"X":1590,"KEGG":"R01771","RHEA_ID":13988,"DIRECTION":"BI","MASTER_ID":13985,"ecocyc":"HOMOSERKIN-RXN","metacyc":"HOMOSERKIN-RXN","compounds":"ATP + L-homoserine <=> ADP + H(+) + O-phospho-L-homoserine","pmd":79.966}
{"X":1591,"KEGG":"R01773","RHEA_ID":15760,"DIRECTION":"BI","MASTER_ID":15757,"compounds":"L-homoserine + NAD(+) <=> H(+) + L-aspartate 4-semialdehyde + NADH","pmd":547.074}
{"X":1592,"KEGG":"R01773","RHEA_ID":15760,"DIRECTION":"BI","MASTER_ID":15757,"compounds":"L-homoserine + NAD(+) <=> H(+) + L-aspartate 4-semialdehyde + NADH","pmd":2.016}
{"X":1593,"KEGG":"R01775","RHEA_ID":15764,"DIRECTION":"BI","MASTER_ID":15761,"compounds":"L-homoserine + NADP(+) <=> H(+) + L-aspartate 4-semialdehyde + NADPH","pmd":2.016}
{"X":1594,"KEGG":"R01775","RHEA_ID":15764,"DIRECTION":"BI","MASTER_ID":15761,"compounds":"L-homoserine + NADP(+) <=> H(+) + L-aspartate 4-semialdehyde + NADPH","pmd":627.041}
{"X":1595,"KEGG":"R01776","RHEA_ID":13704,"DIRECTION":"BI","MASTER_ID":13701,"metacyc":"HOMOSERINE-O-ACETYLTRANSFERASE-RXN","compounds":"acetyl-CoA + L-homoserine <=> CoA + O-acetyl-L-homoserine","pmd":42.011}
{"X":1596,"KEGG":"R01777","RHEA_ID":22011,"DIRECTION":"BI","MASTER_ID":22008,"compounds":"L-homoserine + succinyl-CoA <=> CoA + O-succinyl-L-homoserine","pmd":100.016}
{"X":1597,"KEGG":"R01778","RHEA_ID":22435,"DIRECTION":"BI","MASTER_ID":22432,"compounds":"a (3S)-hydroxyacyl-CoA + NAD(+) <=> a 3-oxoacyl-CoA + H(+) + NADH"}
{"X":1598,"KEGG":"R01779","RHEA_ID":22259,"DIRECTION":"BI","MASTER_ID":22256,"metacyc":"RXN-13279","compounds":"a (3R)-hydroxyacyl-CoA + NADP(+) <=> a 3-oxoacyl-CoA + H(+) + NADPH"}
{"X":1599,"KEGG":"R01780","RHEA_ID":24567,"DIRECTION":"BI","MASTER_ID":24564,"metacyc":"3-OXOACID-COA-TRANSFERASE-RXN","compounds":"a 3-oxo acid + succinyl-CoA <=> a 3-oxoacyl-CoA + succinate","pmd":749.105}
{"X":1600,"KEGG":"R01781","RHEA_ID":27633,"DIRECTION":"BI","MASTER_ID":27630,"ecocyc":"GLYCOLALDREDUCT-RXN","metacyc":"GLYCOLALDREDUCT-RXN","compounds":"ethylene glycol + NAD(+) <=> glycolaldehyde + H(+) + NADH"}
{"X":1601,"KEGG":"R01782","RHEA_ID":20612,"DIRECTION":"BI","MASTER_ID":20609,"compounds":"2-dehydro-3-deoxy-D-arabinonate <=> glycolaldehyde + pyruvate"}
{"X":1602,"KEGG":"R01784","RHEA_ID":18548,"DIRECTION":"BI","MASTER_ID":18545,"metacyc":"4.1.2.18-RXN","compounds":"2-dehydro-3-deoxy-L-arabinonate <=> glycolaldehyde + pyruvate"}
{"X":1603,"KEGG":"R01788","RHEA_ID":44907,"DIRECTION":"BI","MASTER_ID":44904,"compounds":"alpha-D-glucose 6-phosphate + H2O <=> alpha-D-glucose + phosphate","pmd":79.966}
{"X":1604,"KEGG":"R01793","RHEA_ID":32254,"DIRECTION":"BI","MASTER_ID":32251,"compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD(+) <=> (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADH","pmd":2.016}
{"X":1605,"KEGG":"R01793","RHEA_ID":32254,"DIRECTION":"BI","MASTER_ID":32251,"compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD(+) <=> (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADH","pmd":424.007}
{"X":1606,"KEGG":"R01794","RHEA_ID":32250,"DIRECTION":"BI","MASTER_ID":32247,"compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) <=> (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADPH","pmd":2.016}
{"X":1607,"KEGG":"R01794","RHEA_ID":32250,"DIRECTION":"BI","MASTER_ID":32247,"compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) <=> (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADPH","pmd":503.974}
{"X":1608,"KEGG":"R01795","RHEA_ID":30790,"DIRECTION":"BI","MASTER_ID":30787,"compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 <=> (6R)-L-erythro-6,7-dihydrobiopterin + H2O + L-tyrosine","pmd":15.995}
{"X":1609,"KEGG":"R01795","RHEA_ID":30790,"DIRECTION":"BI","MASTER_ID":30787,"compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 <=> (6R)-L-erythro-6,7-dihydrobiopterin + H2O + L-tyrosine","pmd":2.016}
{"X":1610,"KEGG":"R01797","RHEA_ID":15224,"DIRECTION":"BI","MASTER_ID":15221,"ecocyc":"CDPDIGLYPYPHOSPHA-RXN","metacyc":"CDPDIGLYPYPHOSPHA-RXN","compounds":"a CDP-1,2-diacyl-sn-glycerol + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphate + CMP + 2 H(+)"}
{"X":1611,"KEGG":"R01799","RHEA_ID":16232,"DIRECTION":"BI","MASTER_ID":16229,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) <=> a CDP-1,2-diacyl-sn-glycerol + diphosphate"}
{"X":1612,"KEGG":"R01800","RHEA_ID":16916,"DIRECTION":"BI","MASTER_ID":16913,"ecocyc":"PHOSPHASERSYN-RXN","metacyc":"PHOSPHASERSYN-RXN","compounds":"a CDP-1,2-diacyl-sn-glycerol + L-serine <=> 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)","pmd":218.009}
{"X":1613,"KEGG":"R01801","RHEA_ID":12596,"DIRECTION":"BI","MASTER_ID":12593,"ecocyc":"PHOSPHAGLYPSYN-RXN","metacyc":"PHOSPHAGLYPSYN-RXN","compounds":"a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)","pmd":151.038}
{"X":1614,"KEGG":"R01802","RHEA_ID":11583,"DIRECTION":"BI","MASTER_ID":11580,"compounds":"a CDP-1,2-diacyl-sn-glycerol + myo-inositol <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)","pmd":142.988}
{"X":1615,"KEGG":"R01804","RHEA_ID":19276,"DIRECTION":"BI","MASTER_ID":19273,"compounds":"H2O + N-acetyl-D-mannosamine + phosphoenolpyruvate <=> N-acetylneuraminate + phosphate","pmd":88.016}
{"X":1616,"KEGG":"R01806","RHEA_ID":18308,"DIRECTION":"BI","MASTER_ID":18305,"compounds":"acetyl-CoA + N-acetylneuraminate <=> CoA + N-acetyl-4-O-acetylneuraminate","pmd":42.011}
{"X":1617,"KEGG":"R01806","RHEA_ID":18308,"DIRECTION":"BI","MASTER_ID":18305,"compounds":"acetyl-CoA + N-acetylneuraminate <=> CoA + N-acetyl-4-O-acetylneuraminate","pmd":42.01}
{"X":1618,"KEGG":"R01807","RHEA_ID":20811,"DIRECTION":"BI","MASTER_ID":20808,"metacyc":"2.3.1.45-RXN","compounds":"acetyl-CoA + N-acetylneuraminate <=> CoA + N-acetyl-7-O-acetylneuraminate","pmd":42.01}
{"X":1619,"KEGG":"R01807","RHEA_ID":20811,"DIRECTION":"BI","MASTER_ID":20808,"metacyc":"2.3.1.45-RXN","compounds":"acetyl-CoA + N-acetylneuraminate <=> CoA + N-acetyl-7-O-acetylneuraminate","pmd":42.011}
{"X":1620,"KEGG":"R01808","RHEA_ID":26046,"DIRECTION":"BI","MASTER_ID":26043,"metacyc":"RXN-7864","compounds":"acetyl-CoA + N-acetylneuraminate <=> CoA + N-acetyl-9-O-acetylneuraminate","pmd":42.011}
{"X":1621,"KEGG":"R01808","RHEA_ID":26046,"DIRECTION":"BI","MASTER_ID":26043,"metacyc":"RXN-7864","compounds":"acetyl-CoA + N-acetylneuraminate <=> CoA + N-acetyl-9-O-acetylneuraminate","pmd":42.01}
{"X":1622,"KEGG":"R01811","RHEA_ID":23299,"DIRECTION":"BI","MASTER_ID":23296,"ecocyc":"ACNEULY-RXN","metacyc":"ACNEULY-RXN","compounds":"N-acetylneuraminate <=> N-acetyl-D-mannosamine + pyruvate","pmd":88.016}
{"X":1623,"KEGG":"R01812","RHEA_ID":19512,"DIRECTION":"BI","MASTER_ID":19509,"metacyc":"1.1.1.253-RXN","compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) <=> 2 H(+) + L-erythro-biopterin + 2 NADPH","pmd":506.997}
{"X":1624,"KEGG":"R01812","RHEA_ID":19512,"DIRECTION":"BI","MASTER_ID":19509,"metacyc":"1.1.1.253-RXN","compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) <=> 2 H(+) + L-erythro-biopterin + 2 NADPH","pmd":4.031}
{"X":1625,"KEGG":"R01813","RHEA_ID":42503,"DIRECTION":"BI","MASTER_ID":42500,"compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) <=> 6-lactoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH","pmd":2.016}
{"X":1626,"KEGG":"R01813","RHEA_ID":42503,"DIRECTION":"BI","MASTER_ID":42500,"compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) <=> 6-lactoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH","pmd":504.981}
{"X":1627,"KEGG":"R01816","RHEA_ID":21171,"DIRECTION":"BI","MASTER_ID":21168,"compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + anthranilate + O2 <=> (6R)-L-erythro-6,7-dihydrobiopterin + 3-hydroxyanthranilate + H2O","pmd":15.995}
{"X":1628,"KEGG":"R01816","RHEA_ID":21171,"DIRECTION":"BI","MASTER_ID":21168,"compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + anthranilate + O2 <=> (6R)-L-erythro-6,7-dihydrobiopterin + 3-hydroxyanthranilate + H2O","pmd":2.016}
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{"X":1630,"KEGG":"R01817","RHEA_ID":14928,"DIRECTION":"BI","MASTER_ID":14925,"compounds":"D-mannitol 1-phosphate + NADP(+) <=> D-mannose 6-phosphate + H(+) + NADPH","pmd":484.054}
{"X":1631,"KEGG":"R01818","RHEA_ID":11143,"DIRECTION":"BI","MASTER_ID":11140,"ecocyc":"PHOSMANMUT-RXN","metacyc":"PHOSMANMUT-RXN","compounds":"alpha-D-mannose 1-phosphate <=> D-mannose 6-phosphate","pmd":0}
{"X":1632,"KEGG":"R01821","RHEA_ID":41735,"DIRECTION":"BI","MASTER_ID":41732,"ecocyc":"RXN0-5184","metacyc":"RXN0-5184","compounds":"[(1->4)-alpha-D-glucosyl](n) + phosphate <=> [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate"}
{"X":1633,"KEGG":"R01823","RHEA_ID":24575,"DIRECTION":"BI","MASTER_ID":24572,"compounds":"[(1->4)-alpha-D-glucosyl](n) + sucrose <=> [(1->4)-alpha-D-glucosyl](n+1) + D-fructose","pmd":162.053}
{"X":1634,"KEGG":"R01824","RHEA_ID":13624,"DIRECTION":"BI","MASTER_ID":13621,"compounds":"4-[(1->4)-alpha-D-glucosyl](n-1)-D-glucose <=> 1-[(1->4)-alpha-D-glucosyl](n-1)-alpha-D-glucose"}
{"X":1635,"KEGG":"R01825","RHEA_ID":12059,"DIRECTION":"BI","MASTER_ID":12056,"compounds":"D-erythrose 4-phosphate + H2O + NAD(+) <=> 4-phospho-D-erythronate + 2 H(+) + NADH","pmd":448.113}
{"X":1636,"KEGG":"R01825","RHEA_ID":12059,"DIRECTION":"BI","MASTER_ID":12056,"compounds":"D-erythrose 4-phosphate + H2O + NAD(+) <=> 4-phospho-D-erythronate + 2 H(+) + NADH","pmd":15.995}
{"X":1637,"KEGG":"R01826","RHEA_ID":14720,"DIRECTION":"BI","MASTER_ID":14717,"ecocyc":"DAHPSYN-RXN","metacyc":"DAHPSYN-RXN","compounds":"D-erythrose 4-phosphate + H2O + phosphoenolpyruvate <=> 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate","pmd":120.042}
{"X":1638,"KEGG":"R01826","RHEA_ID":14720,"DIRECTION":"BI","MASTER_ID":14717,"ecocyc":"DAHPSYN-RXN","metacyc":"DAHPSYN-RXN","compounds":"D-erythrose 4-phosphate + H2O + phosphoenolpyruvate <=> 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate","pmd":88.016}
{"X":1639,"KEGG":"R01827","RHEA_ID":17056,"DIRECTION":"BI","MASTER_ID":17053,"ecocyc":"TRANSALDOL-RXN","metacyc":"TRANSALDOL-RXN","compounds":"D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate <=> beta-D-fructose 6-phosphate + D-erythrose 4-phosphate","pmd":30.011}
{"X":1640,"KEGG":"R01829","RHEA_ID":30170,"DIRECTION":"BI","MASTER_ID":30167,"metacyc":"SEDOBISALDOL-RXN","compounds":"D-erythrose 4-phosphate + dihydroxyacetone phosphate <=> sedoheptulose 1,7-bisphosphate","pmd":169.998}
{"X":1641,"KEGG":"R01830","RHEA_ID":27629,"DIRECTION":"BI","MASTER_ID":27626,"ecocyc":"2TRANSKETO-RXN","metacyc":"2TRANSKETO-RXN","compounds":"D-erythrose 4-phosphate + D-xylulose 5-phosphate <=> beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate","pmd":30.01}
{"X":1642,"KEGG":"R01830","RHEA_ID":27629,"DIRECTION":"BI","MASTER_ID":27626,"ecocyc":"2TRANSKETO-RXN","metacyc":"2TRANSKETO-RXN","compounds":"D-erythrose 4-phosphate + D-xylulose 5-phosphate <=> beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate","pmd":30.011}
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{"X":1644,"KEGG":"R01834","RHEA_ID":51051,"DIRECTION":"BI","MASTER_ID":51048,"compounds":"5alpha-androstan-3,17-dione + A <=> AH2 + androst-4-ene-3,17-dione","pmd":2.016}
{"X":1645,"KEGG":"R01836","RHEA_ID":14932,"DIRECTION":"BI","MASTER_ID":14929,"metacyc":"TESTOSTERONE-17-BETA-DEHYDROGENASE-RXN","compounds":"NAD(+) + testosterone <=> androst-4-ene-3,17-dione + H(+) + NADH","pmd":377.924}
{"X":1646,"KEGG":"R01836","RHEA_ID":14932,"DIRECTION":"BI","MASTER_ID":14929,"metacyc":"TESTOSTERONE-17-BETA-DEHYDROGENASE-RXN","compounds":"NAD(+) + testosterone <=> androst-4-ene-3,17-dione + H(+) + NADH","pmd":2.016}
{"X":1647,"KEGG":"R01837","RHEA_ID":43935,"DIRECTION":"BI","MASTER_ID":43932,"metacyc":"RXN66-342","compounds":"3beta-hydroxyandrost-5-en-17-one + NAD(+) <=> androst-5-ene-3,17-dione + H(+) + NADH","pmd":2.016}
{"X":1648,"KEGG":"R01837","RHEA_ID":43935,"DIRECTION":"BI","MASTER_ID":43932,"metacyc":"RXN66-342","compounds":"3beta-hydroxyandrost-5-en-17-one + NAD(+) <=> androst-5-ene-3,17-dione + H(+) + NADH","pmd":377.924}
{"X":1649,"KEGG":"R01838","RHEA_ID":14984,"DIRECTION":"BI","MASTER_ID":14981,"compounds":"NADP(+) + testosterone <=> androst-4-ene-3,17-dione + H(+) + NADPH","pmd":457.89}
{"X":1650,"KEGG":"R01838","RHEA_ID":14984,"DIRECTION":"BI","MASTER_ID":14981,"compounds":"NADP(+) + testosterone <=> androst-4-ene-3,17-dione + H(+) + NADPH","pmd":2.016}
{"X":1651,"KEGG":"R01840","RHEA_ID":38202,"DIRECTION":"BI","MASTER_ID":38199,"compounds":"androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":1652,"KEGG":"R01841","RHEA_ID":14756,"DIRECTION":"BI","MASTER_ID":14753,"compounds":"17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] <=> acetate + androst-4-ene-3,17-dione + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
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{"X":1654,"KEGG":"R01844","RHEA_ID":23847,"DIRECTION":"BI","MASTER_ID":23844,"metacyc":"SEDOHEPTULOKINASE-RXN","compounds":"ATP + sedoheptulose <=> ADP + D-sedoheptulose 7-phosphate + H(+)","pmd":79.966}
{"X":1655,"KEGG":"R01845","RHEA_ID":17464,"DIRECTION":"BI","MASTER_ID":17461,"compounds":"H2O + sedoheptulose 1,7-bisphosphate <=> D-sedoheptulose 7-phosphate + phosphate","pmd":79.966}
{"X":1656,"KEGG":"R01850","RHEA_ID":16628,"DIRECTION":"BI","MASTER_ID":16625,"compounds":"acetyl-CoA + hydrogen sulfide <=> CoA + thioacetate","pmd":42.011}
{"X":1657,"KEGG":"R01851","RHEA_ID":11815,"DIRECTION":"BI","MASTER_ID":11812,"compounds":"H2O + methanethiol + O2 <=> formaldehyde + H(+) + H2O2 + hydrogen sulfide"}
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{"X":1659,"KEGG":"R01853","RHEA_ID":26417,"DIRECTION":"BI","MASTER_ID":26414,"compounds":"a secondary aliphatic amine + H2O + O2 <=> a primary amine + an aldehyde + H2O2"}
{"X":1660,"KEGG":"R01855","RHEA_ID":28365,"DIRECTION":"BI","MASTER_ID":28362,"ecocyc":"RXN0-385","metacyc":"RXN0-385","compounds":"dGTP + H2O <=> dGMP + diphosphate + H(+)","pmd":159.933}
{"X":1661,"KEGG":"R01856","RHEA_ID":15196,"DIRECTION":"BI","MASTER_ID":15193,"compounds":"dGTP + H2O <=> 2'-deoxyguanosine + H(+) + triphosphate","pmd":239.899}
{"X":1662,"KEGG":"R01857","RHEA_ID":27693,"DIRECTION":"BI","MASTER_ID":27690,"compounds":"ATP + dGDP <=> ADP + dGTP","pmd":0}
{"X":1663,"KEGG":"R01858","RHEA_ID":30794,"DIRECTION":"BI","MASTER_ID":30791,"compounds":"dGTP + pyruvate <=> dGDP + H(+) + phosphoenolpyruvate","pmd":79.966}
{"X":1664,"KEGG":"R01859","RHEA_ID":23723,"DIRECTION":"BI","MASTER_ID":23720,"metacyc":"PROPIONYL-COA-CARBOXY-RXN","compounds":"ATP + hydrogencarbonate + propanoyl-CoA <=> (S)-methylmalonyl-CoA + ADP + H(+) + phosphate","pmd":79.966}
{"X":1665,"KEGG":"R01859","RHEA_ID":23723,"DIRECTION":"BI","MASTER_ID":23720,"metacyc":"PROPIONYL-COA-CARBOXY-RXN","compounds":"ATP + hydrogencarbonate + propanoyl-CoA <=> (S)-methylmalonyl-CoA + ADP + H(+) + phosphate","pmd":43.99}
{"X":1666,"KEGG":"R01860","RHEA_ID":24203,"DIRECTION":"BI","MASTER_ID":24200,"metacyc":"AMINOBENZOATE-DECARBOXYLASE-RXN","compounds":"4-aminobenzoate + H(+) <=> aniline + CO2"}
{"X":1667,"KEGG":"R01862","RHEA_ID":20300,"DIRECTION":"BI","MASTER_ID":20297,"compounds":"an anilide + H2O <=> a carboxylate + aniline + H(+)"}
{"X":1668,"KEGG":"R01863","RHEA_ID":27649,"DIRECTION":"BI","MASTER_ID":27646,"ecocyc":"INOPHOSPHOR-RXN","metacyc":"INOPHOSPHOR-RXN","compounds":"inosine + phosphate <=> alpha-D-ribose 1-phosphate + hypoxanthine","pmd":38.062}
{"X":1669,"KEGG":"R01866","RHEA_ID":14864,"DIRECTION":"BI","MASTER_ID":14861,"compounds":"(S)-dihydroorotate + NADP(+) <=> H(+) + NADPH + orotate","pmd":2.016}
{"X":1670,"KEGG":"R01866","RHEA_ID":14864,"DIRECTION":"BI","MASTER_ID":14861,"compounds":"(S)-dihydroorotate + NADP(+) <=> H(+) + NADPH + orotate","pmd":588.066}
{"X":1671,"KEGG":"R01867","RHEA_ID":30062,"DIRECTION":"BI","MASTER_ID":30059,"compounds":"(S)-dihydroorotate + fumarate <=> orotate + succinate","pmd":2.016}
{"X":1672,"KEGG":"R01868","RHEA_ID":18076,"DIRECTION":"BI","MASTER_ID":18073,"compounds":"(S)-dihydroorotate + A <=> AH2 + orotate","pmd":2.016}
{"X":1673,"KEGG":"R01868","RHEA_ID":30190,"DIRECTION":"BI","MASTER_ID":30187,"compounds":"(S)-dihydroorotate + a quinone <=> a quinol + orotate","pmd":2.016}
{"X":1674,"KEGG":"R01869","RHEA_ID":13516,"DIRECTION":"BI","MASTER_ID":13513,"metacyc":"OROTATE-REDUCTASE-NADH-RXN","compounds":"(S)-dihydroorotate + NAD(+) <=> H(+) + NADH + orotate","pmd":508.1}
{"X":1675,"KEGG":"R01869","RHEA_ID":13516,"DIRECTION":"BI","MASTER_ID":13513,"metacyc":"OROTATE-REDUCTASE-NADH-RXN","compounds":"(S)-dihydroorotate + NAD(+) <=> H(+) + NADH + orotate","pmd":2.016}
{"X":1676,"KEGG":"R01870","RHEA_ID":10383,"DIRECTION":"BI","MASTER_ID":10380,"ecocyc":"OROPRIBTRANS-RXN","metacyc":"OROPRIBTRANS-RXN","compounds":"diphosphate + orotidine 5'-phosphate <=> 5-phospho-alpha-D-ribose 1-diphosphate + orotate","pmd":21.926}
{"X":1677,"KEGG":"R01872","RHEA_ID":22367,"DIRECTION":"BI","MASTER_ID":22364,"compounds":"L-quinate + NAD(+) <=> 3-dehydroquinate + H(+) + NADH","pmd":2.016}
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{"X":1680,"KEGG":"R01874","RHEA_ID":11271,"DIRECTION":"BI","MASTER_ID":11268,"ecocyc":"DCYSDESULF-RXN","metacyc":"DCYSDESULF-RXN","compounds":"D-cysteine + H2O <=> H(+) + hydrogen sulfide + NH4(+) + pyruvate"}
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{"X":1684,"KEGG":"R01878","RHEA_ID":16072,"DIRECTION":"BI","MASTER_ID":16069,"compounds":"cytidine + H(+) + H2O <=> NH4(+) + uridine","pmd":0.984}
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{"X":1686,"KEGG":"R01879","RHEA_ID":21079,"DIRECTION":"BI","MASTER_ID":21076,"compounds":"2'-deoxyuridine + 2-oxoglutarate + O2 <=> CO2 + succinate + uridine","pmd":27.995}
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{"X":1689,"KEGG":"R01883","RHEA_ID":10659,"DIRECTION":"BI","MASTER_ID":10656,"compounds":"guanidinoacetate + S-adenosyl-L-methionine <=> creatine + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":1690,"KEGG":"R01884","RHEA_ID":14536,"DIRECTION":"BI","MASTER_ID":14533,"metacyc":"CREATININASE-RXN","compounds":"creatinine + H2O <=> creatine","pmd":18.011}
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{"X":1693,"KEGG":"R01889","RHEA_ID":16452,"DIRECTION":"BI","MASTER_ID":16449,"metacyc":"AMINOGLYCOSIDE-N6-ACETYLTRANSFERASE-RXN","compounds":"acetyl-CoA + kanamycin B <=> CoA + H(+) + N(6')-acetylkanamycin B","pmd":42.011}
{"X":1694,"KEGG":"R01890","RHEA_ID":19000,"DIRECTION":"BI","MASTER_ID":18997,"compounds":"CTP + H(+) + phosphocholine <=> CDP-choline + diphosphate","pmd":5.123}
{"X":1695,"KEGG":"R01890","RHEA_ID":19000,"DIRECTION":"BI","MASTER_ID":18997,"compounds":"CTP + H(+) + phosphocholine <=> CDP-choline + diphosphate","pmd":304.033}
{"X":1696,"KEGG":"R01891","RHEA_ID":16276,"DIRECTION":"BI","MASTER_ID":16273,"compounds":"an N-acylsphing-4-enine + CDP-choline <=> CMP + H(+) + sphingomyelin","pmd":165.055}
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{"X":1698,"KEGG":"R01895","RHEA_ID":20056,"DIRECTION":"BI","MASTER_ID":20053,"compounds":"NAD(+) + ribitol <=> D-ribulose + H(+) + NADH","pmd":514.064}
{"X":1699,"KEGG":"R01896","RHEA_ID":20436,"DIRECTION":"BI","MASTER_ID":20433,"metacyc":"D-XYLULOSE-REDUCTASE-RXN","compounds":"NAD(+) + xylitol <=> D-xylulose + H(+) + NADH","pmd":2.016}
{"X":1700,"KEGG":"R01896","RHEA_ID":20436,"DIRECTION":"BI","MASTER_ID":20433,"metacyc":"D-XYLULOSE-REDUCTASE-RXN","compounds":"NAD(+) + xylitol <=> D-xylulose + H(+) + NADH","pmd":514.064}
{"X":1701,"KEGG":"R01898","RHEA_ID":14204,"DIRECTION":"BI","MASTER_ID":14201,"metacyc":"D-LYXOSE-KETOL-ISOMERASE-RXN","compounds":"D-lyxose <=> D-xylulose","pmd":0}
{"X":1702,"KEGG":"R01899","RHEA_ID":25591,"DIRECTION":"BI","MASTER_ID":25588,"ecocyc":"RXN-9951","metacyc":"RXN-9951","compounds":"isocitrate + NADP(+) <=> H(+) + NADPH + oxalosuccinate","pmd":2.016}
{"X":1703,"KEGG":"R01899","RHEA_ID":25591,"DIRECTION":"BI","MASTER_ID":25588,"ecocyc":"RXN-9951","metacyc":"RXN-9951","compounds":"isocitrate + NADP(+) <=> H(+) + NADPH + oxalosuccinate","pmd":554.072}
{"X":1704,"KEGG":"R01900","RHEA_ID":22147,"DIRECTION":"BI","MASTER_ID":22144,"ecocyc":"ACONITATEHYDR-RXN","metacyc":"ACONITATEHYDR-RXN","compounds":"cis-aconitate + H2O <=> isocitrate","pmd":18.011}
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{"X":1706,"KEGG":"R01903","RHEA_ID":16384,"DIRECTION":"BI","MASTER_ID":16381,"metacyc":"L-ARABINITOL-4-DEHYDROGENASE-RXN","compounds":"L-arabinitol + NAD(+) <=> H(+) + L-xylulose + NADH","pmd":514.064}
{"X":1707,"KEGG":"R01903","RHEA_ID":16384,"DIRECTION":"BI","MASTER_ID":16381,"metacyc":"L-ARABINITOL-4-DEHYDROGENASE-RXN","compounds":"L-arabinitol + NAD(+) <=> H(+) + L-xylulose + NADH","pmd":2.016}
{"X":1708,"KEGG":"R01904","RHEA_ID":17028,"DIRECTION":"BI","MASTER_ID":17025,"metacyc":"L-XYLULOSE-REDUCTASE-RXN","compounds":"NADP(+) + xylitol <=> H(+) + L-xylulose + NADPH","pmd":2.016}
{"X":1709,"KEGG":"R01904","RHEA_ID":17028,"DIRECTION":"BI","MASTER_ID":17025,"metacyc":"L-XYLULOSE-REDUCTASE-RXN","compounds":"NADP(+) + xylitol <=> H(+) + L-xylulose + NADPH","pmd":594.031}
{"X":1710,"KEGG":"R01905","RHEA_ID":11087,"DIRECTION":"BI","MASTER_ID":11084,"compounds":"3-dehydro-L-gulonate + H(+) <=> CO2 + L-xylulose","pmd":43.99}
{"X":1711,"KEGG":"R01906","RHEA_ID":28061,"DIRECTION":"BI","MASTER_ID":28058,"ecocyc":"LYXISOM-RXN","metacyc":"LYXISOM-RXN","compounds":"L-lyxose <=> L-xylulose","pmd":0}
{"X":1712,"KEGG":"R01908","RHEA_ID":19336,"DIRECTION":"BI","MASTER_ID":19333,"compounds":"H(+) + oxalyl-CoA <=> CO2 + formyl-CoA","pmd":43.99}
{"X":1713,"KEGG":"R01909","RHEA_ID":25111,"DIRECTION":"BI","MASTER_ID":25108,"compounds":"ATP + pyridoxine <=> ADP + H(+) + pyridoxine 5'-phosphate","pmd":79.966}
{"X":1714,"KEGG":"R01911","RHEA_ID":25115,"DIRECTION":"BI","MASTER_ID":25112,"compounds":"H2O + pyridoxine 5'-phosphate <=> phosphate + pyridoxine","pmd":79.966}
{"X":1715,"KEGG":"R01912","RHEA_ID":20180,"DIRECTION":"BI","MASTER_ID":20177,"compounds":"pyridoxine + UDP-alpha-D-glucose <=> 5'-O-beta-D-glucosylpyridoxine + H(+) + UDP","pmd":162.053}
{"X":1716,"KEGG":"R01914","RHEA_ID":25823,"DIRECTION":"BI","MASTER_ID":25820,"compounds":"H2O + O2 + spermidine <=> 4-aminobutanal + H2O2 + propane-1,3-diamine"}
{"X":1717,"KEGG":"R01915","RHEA_ID":14276,"DIRECTION":"BI","MASTER_ID":14273,"compounds":"A + H2O + spermidine <=> 4-aminobutanal + AH2 + propane-1,3-diamine"}
{"X":1718,"KEGG":"R01917","RHEA_ID":21275,"DIRECTION":"BI","MASTER_ID":21272,"metacyc":"GSPSYN-RXN","compounds":"ATP + glutathione + spermidine <=> ADP + glutathionylspermidine + H(+) + phosphate","pmd":72.765}
{"X":1719,"KEGG":"R01917","RHEA_ID":21275,"DIRECTION":"BI","MASTER_ID":21272,"metacyc":"GSPSYN-RXN","compounds":"ATP + glutathione + spermidine <=> ADP + glutathionylspermidine + H(+) + phosphate","pmd":281.871}
{"X":1720,"KEGG":"R01917","RHEA_ID":21275,"DIRECTION":"BI","MASTER_ID":21272,"metacyc":"GSPSYN-RXN","compounds":"ATP + glutathione + spermidine <=> ADP + glutathionylspermidine + H(+) + phosphate","pmd":119.946}
{"X":1721,"KEGG":"R01918","RHEA_ID":17176,"DIRECTION":"BI","MASTER_ID":17173,"metacyc":"GSPAMID-RXN","compounds":"glutathionylspermidine + H2O <=> glutathione + spermidine","pmd":127.147}
{"X":1722,"KEGG":"R01919","RHEA_ID":11239,"DIRECTION":"BI","MASTER_ID":11236,"compounds":"putrescine + spermidine <=> propane-1,3-diamine + sym-homospermidine","pmd":14.016}
{"X":1723,"KEGG":"R01920","RHEA_ID":12724,"DIRECTION":"BI","MASTER_ID":12721,"metacyc":"SPERMIDINESYN-RXN","compounds":"putrescine + S-adenosyl 3-(methylsulfanyl)propylamine <=> H(+) + S-methyl-5'-thioadenosine + spermidine","pmd":58.066}
{"X":1724,"KEGG":"R01921","RHEA_ID":11559,"DIRECTION":"BI","MASTER_ID":11556,"metacyc":"1.1.1.254-RXN","compounds":"(S)-carnitine + NAD(+) <=> 3-dehydrocarnitine + H(+) + NADH","pmd":504.02}
{"X":1725,"KEGG":"R01921","RHEA_ID":11559,"DIRECTION":"BI","MASTER_ID":11556,"metacyc":"1.1.1.254-RXN","compounds":"(S)-carnitine + NAD(+) <=> 3-dehydrocarnitine + H(+) + NADH","pmd":504.019}
{"X":1726,"KEGG":"R01922","RHEA_ID":17540,"DIRECTION":"BI","MASTER_ID":17537,"compounds":"(R)-carnitinamide + H2O <=> (R)-carnitine + NH4(+)","pmd":0.024}
{"X":1727,"KEGG":"R01923","RHEA_ID":12664,"DIRECTION":"BI","MASTER_ID":12661,"metacyc":"CARNITINE-O-PALMITOYLTRANSFERASE-RXN","compounds":"(R)-carnitine + hexadecanoyl-CoA <=> CoA + O-hexadecanoyl-(R)-carnitine","pmd":238.23}
{"X":1728,"KEGG":"R01924","RHEA_ID":17104,"DIRECTION":"BI","MASTER_ID":17101,"compounds":"H2O + O-acyl-(R)-carnitine <=> (R)-carnitine + a fatty acid + H(+)"}
{"X":1729,"KEGG":"R01925","RHEA_ID":14580,"DIRECTION":"BI","MASTER_ID":14577,"metacyc":"CARNDEHYDRA-RXN","compounds":"(R)-carnitine <=> crotonobetaine + H2O"}
{"X":1730,"KEGG":"R01926","RHEA_ID":35850,"DIRECTION":"BI","MASTER_ID":35847,"compounds":"ATP + sphing-4-enine <=> ADP + H(+) + sphing-4-enine 1-phosphate","pmd":79.966}
{"X":1731,"KEGG":"R01928","RHEA_ID":19488,"DIRECTION":"BI","MASTER_ID":19485,"compounds":"sphing-4-enine + UDP-alpha-D-galactose <=> beta-D-galactosyl-(1<->1)-sphing-4-enine + H(+) + UDP","pmd":104.72}
{"X":1732,"KEGG":"R01929","RHEA_ID":21227,"DIRECTION":"BI","MASTER_ID":21224,"compounds":"CDP-choline + sphing-4-enine <=> CMP + H(+) + sphing-4-enine-phosphocholine","pmd":22.762}
{"X":1733,"KEGG":"R01929","RHEA_ID":21227,"DIRECTION":"BI","MASTER_ID":21224,"compounds":"CDP-choline + sphing-4-enine <=> CMP + H(+) + sphing-4-enine-phosphocholine","pmd":23.769}
{"X":1734,"KEGG":"R01930","RHEA_ID":21887,"DIRECTION":"BI","MASTER_ID":21884,"metacyc":"3.12.1.1-RXN","compounds":"H2O + trithionate <=> H(+) + sulfate + thiosulfate"}
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{"X":1736,"KEGG":"R01932","RHEA_ID":14796,"DIRECTION":"BI","MASTER_ID":14793,"compounds":"2-hydroxyadipate + NAD(+) <=> 2-oxoadipate + H(+) + NADH","pmd":503.072}
{"X":1737,"KEGG":"R01932","RHEA_ID":14796,"DIRECTION":"BI","MASTER_ID":14793,"compounds":"2-hydroxyadipate + NAD(+) <=> 2-oxoadipate + H(+) + NADH","pmd":2.016}
{"X":1738,"KEGG":"R01933","RHEA_ID":30798,"DIRECTION":"BI","MASTER_ID":30795,"compounds":"2-oxoadipate + CoA + NAD(+) <=> CO2 + glutaryl-CoA + NADH","pmd":101.99}
{"X":1739,"KEGG":"R01933","RHEA_ID":30798,"DIRECTION":"BI","MASTER_ID":30795,"compounds":"2-oxoadipate + CoA + NAD(+) <=> CO2 + glutaryl-CoA + NADH","pmd":217.03}
{"X":1740,"KEGG":"R01933","RHEA_ID":30798,"DIRECTION":"BI","MASTER_ID":30795,"compounds":"2-oxoadipate + CoA + NAD(+) <=> CO2 + glutaryl-CoA + NADH","pmd":505.088}
{"X":1741,"KEGG":"R01934","RHEA_ID":11903,"DIRECTION":"BI","MASTER_ID":11900,"compounds":"(1R,2S)-homoisocitrate + NAD(+) <=> 2-oxoadipate + CO2 + NADH","pmd":504.08}
{"X":1742,"KEGG":"R01934","RHEA_ID":11903,"DIRECTION":"BI","MASTER_ID":11900,"compounds":"(1R,2S)-homoisocitrate + NAD(+) <=> 2-oxoadipate + CO2 + NADH","pmd":46.005}
{"X":1743,"KEGG":"R01939","RHEA_ID":12604,"DIRECTION":"BI","MASTER_ID":12601,"metacyc":"2-AMINOADIPATE-AMINOTRANSFERASE-RXN","compounds":"2-oxoglutarate + L-2-aminoadipate <=> 2-oxoadipate + L-glutamate","pmd":1.032}
{"X":1744,"KEGG":"R01940","RHEA_ID":12191,"DIRECTION":"BI","MASTER_ID":12188,"compounds":"2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase]-(R)-N(6)-lipoyl-L-lysine + H(+) <=> [dihydrolipoyllysine-residue succinyltransferase]-(R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysine + CO2"}
{"X":1745,"KEGG":"R01942","RHEA_ID":16928,"DIRECTION":"BI","MASTER_ID":16925,"compounds":"(E)-caffeoyl-CoA + S-adenosyl-L-methionine <=> (E)-feruloyl-CoA + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":1746,"KEGG":"R01943","RHEA_ID":36302,"DIRECTION":"BI","MASTER_ID":36299,"compounds":"(E)-caffeate + ATP + CoA <=> AMP + caffeoyl-CoA + diphosphate","pmd":159.933}
{"X":1747,"KEGG":"R01943","RHEA_ID":36302,"DIRECTION":"BI","MASTER_ID":36299,"compounds":"(E)-caffeate + ATP + CoA <=> AMP + caffeoyl-CoA + diphosphate","pmd":162.032}
{"X":1748,"KEGG":"R01943","RHEA_ID":36302,"DIRECTION":"BI","MASTER_ID":36299,"compounds":"(E)-caffeate + ATP + CoA <=> AMP + caffeoyl-CoA + diphosphate","pmd":167.021}
{"X":1749,"KEGG":"R01944","RHEA_ID":12439,"DIRECTION":"BI","MASTER_ID":12436,"compounds":"caffeoyl-CoA + putrescine <=> CoA + H(+) + N-caffeoylputrescine","pmd":162.032}
{"X":1750,"KEGG":"R01946","RHEA_ID":20759,"DIRECTION":"BI","MASTER_ID":20756,"compounds":"caffeoyl-CoA + isocitrate <=> 2-caffeoylisocitrate + CoA","pmd":162.032}
{"X":1751,"KEGG":"R01951","RHEA_ID":13552,"DIRECTION":"BI","MASTER_ID":13549,"compounds":"beta-L-fucose 1-phosphate + GTP + H(+) <=> diphosphate + GDP-beta-L-fucose","pmd":345.047}
{"X":1752,"KEGG":"R01951","RHEA_ID":13552,"DIRECTION":"BI","MASTER_ID":13549,"compounds":"beta-L-fucose 1-phosphate + GTP + H(+) <=> diphosphate + GDP-beta-L-fucose","pmd":66.091}
{"X":1753,"KEGG":"R01954","RHEA_ID":10935,"DIRECTION":"BI","MASTER_ID":10932,"compounds":"ATP + L-aspartate + L-citrulline <=> 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)","pmd":159.933}
{"X":1754,"KEGG":"R01954","RHEA_ID":10935,"DIRECTION":"BI","MASTER_ID":10932,"compounds":"ATP + L-aspartate + L-citrulline <=> 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)","pmd":157.085}
{"X":1755,"KEGG":"R01954","RHEA_ID":10935,"DIRECTION":"BI","MASTER_ID":10932,"compounds":"ATP + L-aspartate + L-citrulline <=> 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)","pmd":115.027}
{"X":1756,"KEGG":"R01956","RHEA_ID":20967,"DIRECTION":"BI","MASTER_ID":20964,"compounds":"2-oxoglutarate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate","pmd":1.032}
{"X":1757,"KEGG":"R01957","RHEA_ID":19252,"DIRECTION":"BI","MASTER_ID":19249,"metacyc":"2.6.1.63-RXN","compounds":"glyoxylate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine","pmd":1.032}
{"X":1758,"KEGG":"R01959","RHEA_ID":13012,"DIRECTION":"BI","MASTER_ID":13009,"compounds":"H2O + N-formyl-L-kynurenine <=> formate + H(+) + L-kynurenine","pmd":27.995}
{"X":1759,"KEGG":"R01960","RHEA_ID":20548,"DIRECTION":"BI","MASTER_ID":20545,"compounds":"H(+) + L-kynurenine + NADPH + O2 <=> 3-hydroxy-L-kynurenine + H2O + NADP(+)","pmd":521.011}
{"X":1760,"KEGG":"R01960","RHEA_ID":20548,"DIRECTION":"BI","MASTER_ID":20545,"compounds":"H(+) + L-kynurenine + NADPH + O2 <=> 3-hydroxy-L-kynurenine + H2O + NADP(+)","pmd":15.995}
{"X":1761,"KEGG":"R01961","RHEA_ID":10951,"DIRECTION":"BI","MASTER_ID":10948,"metacyc":"GLUCOSAMINE-KINASE-RXN","compounds":"ATP + D-glucosamine <=> ADP + D-glucosamine 6-phosphate + H(+)","pmd":79.966}
{"X":1762,"KEGG":"R01963","RHEA_ID":17884,"DIRECTION":"BI","MASTER_ID":17881,"compounds":"H2O + N-sulfo-D-glucosamine <=> D-glucosamine + sulfate","pmd":79.957}
{"X":1763,"KEGG":"R01967","RHEA_ID":19204,"DIRECTION":"BI","MASTER_ID":19201,"compounds":"2'-deoxyguanosine + ATP <=> ADP + dGMP + H(+)","pmd":79.966}
{"X":1764,"KEGG":"R01968","RHEA_ID":29382,"DIRECTION":"BI","MASTER_ID":29379,"compounds":"dGMP + H2O <=> 2'-deoxyguanosine + phosphate","pmd":79.966}
{"X":1765,"KEGG":"R01969","RHEA_ID":27741,"DIRECTION":"BI","MASTER_ID":27738,"ecocyc":"DEOXYGUANPHOSPHOR-RXN","metacyc":"DEOXYGUANPHOSPHOR-RXN","compounds":"2'-deoxyguanosine + phosphate <=> 2-deoxy-alpha-D-ribose 1-phosphate + guanine","pmd":53.073}
{"X":1766,"KEGG":"R01971","RHEA_ID":20136,"DIRECTION":"BI","MASTER_ID":20133,"metacyc":"INDOLELACTATE-DEHYDROGENASE-RXN","compounds":"3-(indol-3-yl)lactate + NAD(+) <=> H(+) + indole-3-pyruvate + NADH"}
{"X":1767,"KEGG":"R01972","RHEA_ID":12115,"DIRECTION":"BI","MASTER_ID":12112,"compounds":"indole-3-pyruvate + S-adenosyl-L-methionine <=> (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":1768,"KEGG":"R01974","RHEA_ID":18020,"DIRECTION":"BI","MASTER_ID":18017,"compounds":"H(+) + indole-3-pyruvate <=> CO2 + indole-3-acetaldehyde","pmd":43.99}
{"X":1769,"KEGG":"R01975","RHEA_ID":30802,"DIRECTION":"BI","MASTER_ID":30799,"metacyc":"RXN-11662","compounds":"(3S)-hydroxybutanoyl-CoA + NAD(+) <=> acetoacetyl-CoA + H(+) + NADH","pmd":187.019}
{"X":1770,"KEGG":"R01975","RHEA_ID":30802,"DIRECTION":"BI","MASTER_ID":30799,"metacyc":"RXN-11662","compounds":"(3S)-hydroxybutanoyl-CoA + NAD(+) <=> acetoacetyl-CoA + H(+) + NADH","pmd":2.016}
{"X":1771,"KEGG":"R01976","RHEA_ID":16200,"DIRECTION":"BI","MASTER_ID":16197,"compounds":"(3S)-hydroxybutanoyl-CoA + NADP(+) <=> acetoacetyl-CoA + H(+) + NADPH","pmd":2.016}
{"X":1772,"KEGG":"R01976","RHEA_ID":16200,"DIRECTION":"BI","MASTER_ID":16197,"compounds":"(3S)-hydroxybutanoyl-CoA + NADP(+) <=> acetoacetyl-CoA + H(+) + NADPH","pmd":107.053}
{"X":1773,"KEGG":"R01977","RHEA_ID":45799,"DIRECTION":"BI","MASTER_ID":45796,"compounds":"(3R)-hydroxybutanoyl-CoA + NADP(+) <=> acetoacetyl-CoA + H(+) + NADPH","pmd":107.053}
{"X":1774,"KEGG":"R01977","RHEA_ID":45799,"DIRECTION":"BI","MASTER_ID":45796,"compounds":"(3R)-hydroxybutanoyl-CoA + NADP(+) <=> acetoacetyl-CoA + H(+) + NADPH","pmd":2.016}
{"X":1775,"KEGG":"R01978","RHEA_ID":10191,"DIRECTION":"BI","MASTER_ID":10188,"metacyc":"HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN","compounds":"acetoacetyl-CoA + acetyl-CoA + H2O <=> (3S)-hydroxy-3-methylglutaryl-CoA + CoA + H(+)","pmd":42.011}
{"X":1776,"KEGG":"R01978","RHEA_ID":10191,"DIRECTION":"BI","MASTER_ID":10188,"metacyc":"HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN","compounds":"acetoacetyl-CoA + acetyl-CoA + H2O <=> (3S)-hydroxy-3-methylglutaryl-CoA + CoA + H(+)","pmd":60.021}
{"X":1777,"KEGG":"R01980","RHEA_ID":12968,"DIRECTION":"BI","MASTER_ID":12965,"compounds":"ATP + D-galactupyranuronate <=> 1-phospho-alpha-D-galacturonate + ADP + H(+)","pmd":79.966}
{"X":1778,"KEGG":"R01983","RHEA_ID":27705,"DIRECTION":"BI","MASTER_ID":27702,"ecocyc":"GALACTUROISOM-RXN","metacyc":"GALACTUROISOM-RXN","compounds":"aldehydo-D-galacturonate <=> keto-D-tagaturonate","pmd":0}
{"X":1779,"KEGG":"R01986","RHEA_ID":30806,"DIRECTION":"BI","MASTER_ID":30803,"compounds":"4-aminobutanal + H2O + NADP(+) <=> 4-aminobutanoate + 2 H(+) + NADPH","pmd":641.02}
{"X":1780,"KEGG":"R01987","RHEA_ID":18904,"DIRECTION":"BI","MASTER_ID":18901,"compounds":"H(+) + H2O + N-benzyloxycarbonyl-L-leucine <=> benzyl alcohol + CO2 + L-leucine","pmd":42.011}
{"X":1781,"KEGG":"R01987","RHEA_ID":15900,"DIRECTION":"BI","MASTER_ID":15897,"compounds":"4-acetamidobutanoate + H2O <=> 4-aminobutanoate + acetate","pmd":42.011}
{"X":1782,"KEGG":"R01990","RHEA_ID":19504,"DIRECTION":"BI","MASTER_ID":19501,"compounds":"4-guanidinobutanoate + H2O <=> 4-aminobutanoate + urea","pmd":42.022}
{"X":1783,"KEGG":"R01991","RHEA_ID":59571,"DIRECTION":"BI","MASTER_ID":59568,"compounds":"4-aminobutanoate + ATP + L-histidine <=> ADP + H(+) + L-homocarnosine + phosphate","pmd":137.059}
{"X":1784,"KEGG":"R01991","RHEA_ID":59571,"DIRECTION":"BI","MASTER_ID":59568,"compounds":"4-aminobutanoate + ATP + L-histidine <=> ADP + H(+) + L-homocarnosine + phosphate","pmd":85.053}
{"X":1785,"KEGG":"R01991","RHEA_ID":59571,"DIRECTION":"BI","MASTER_ID":59568,"compounds":"4-aminobutanoate + ATP + L-histidine <=> ADP + H(+) + L-homocarnosine + phosphate","pmd":79.966}
{"X":1786,"KEGG":"R01992","RHEA_ID":59575,"DIRECTION":"BI","MASTER_ID":59572,"compounds":"H2O + L-homocarnosine <=> 4-aminobutanoate + L-histidine","pmd":85.053}
{"X":1787,"KEGG":"R01993","RHEA_ID":24299,"DIRECTION":"BI","MASTER_ID":24296,"ecocyc":"DIHYDROOROT-RXN","metacyc":"DIHYDROOROT-RXN","compounds":"(S)-dihydroorotate + H2O <=> H(+) + N-carbamoyl-L-aspartate","pmd":18.01}
{"X":1788,"KEGG":"R01998","RHEA_ID":17980,"DIRECTION":"BI","MASTER_ID":17977,"metacyc":"LONG-CHAIN-ALCOHOL-DEHYDROGENASE-RXN","compounds":"a long-chain primary fatty alcohol + H2O + 2 NAD(+) <=> a long-chain fatty acid + 3 H(+) + 2 NADH"}
{"X":1789,"KEGG":"R01999","RHEA_ID":38446,"DIRECTION":"BI","MASTER_ID":38443,"compounds":"a long chain fatty alcohol + an acyl-CoA <=> a wax ester + CoA"}
{"X":1790,"KEGG":"R02000","RHEA_ID":18600,"DIRECTION":"BI","MASTER_ID":18597,"metacyc":"RUBREDOXIN--NAD%2b-REDUCTASE-RXN","compounds":"H(+) + NAD(+) + 2 reduced [rubredoxin] <=> NADH + 2 oxidized [rubredoxin]"}
{"X":1791,"KEGG":"R02000","RHEA_ID":18600,"DIRECTION":"BI","MASTER_ID":18597,"metacyc":"RUBREDOXIN--NADP%2b-REDUCTASE-RXN","compounds":"H(+) + NAD(+) + 2 reduced [rubredoxin] <=> NADH + 2 oxidized [rubredoxin]"}
{"X":1792,"KEGG":"R02002","RHEA_ID":13952,"DIRECTION":"BI","MASTER_ID":13949,"metacyc":"RUBREDOXIN--NADP%2b-REDUCTASE-RXN","compounds":"H(+) + NADP(+) + 2 reduced [rubredoxin] <=> NADPH + 2 oxidized [rubredoxin]"}
{"X":1793,"KEGG":"R02003","RHEA_ID":19364,"DIRECTION":"BI","MASTER_ID":19361,"metacyc":"FPPSYN-RXN","compounds":"(2E)-geranyl diphosphate + isopentenyl diphosphate <=> (2E,6E)-farnesyl diphosphate + diphosphate","pmd":136.125}
{"X":1794,"KEGG":"R02003","RHEA_ID":19364,"DIRECTION":"BI","MASTER_ID":19361,"metacyc":"FPPSYN-RXN","compounds":"(2E)-geranyl diphosphate + isopentenyl diphosphate <=> (2E,6E)-farnesyl diphosphate + diphosphate","pmd":68.063}
{"X":1795,"KEGG":"R02004","RHEA_ID":20568,"DIRECTION":"BI","MASTER_ID":20565,"compounds":"(2E)-geranyl diphosphate + H2O <=> (1S,2S,4R)-endo-fenchol + diphosphate","pmd":159.933}
{"X":1796,"KEGG":"R02006","RHEA_ID":19568,"DIRECTION":"BI","MASTER_ID":19565,"compounds":"(2E)-geranyl diphosphate + H2O <=> diphosphate + sabinene hydrate","pmd":159.933}
{"X":1797,"KEGG":"R02007","RHEA_ID":18212,"DIRECTION":"BI","MASTER_ID":18209,"compounds":"(2E)-geranyl diphosphate <=> (2S,4R)-bornyl diphosphate","pmd":0}
{"X":1798,"KEGG":"R02009","RHEA_ID":16968,"DIRECTION":"BI","MASTER_ID":16965,"compounds":"(2E)-geranyl diphosphate <=> beta-myrcene + diphosphate","pmd":177.943}
{"X":1799,"KEGG":"R02010","RHEA_ID":25503,"DIRECTION":"BI","MASTER_ID":25500,"compounds":"(2E)-geranyl diphosphate <=> diphosphate + terpinolene","pmd":177.943}
{"X":1800,"KEGG":"R02013","RHEA_ID":12872,"DIRECTION":"BI","MASTER_ID":12869,"compounds":"(2E)-geranyl diphosphate <=> (4S)-limonene + diphosphate","pmd":177.943}
{"X":1801,"KEGG":"R02016","RHEA_ID":20348,"DIRECTION":"BI","MASTER_ID":20345,"metacyc":"THIOREDOXIN-REDUCT-NADPH-RXN","compounds":"[thioredoxin]-dithiol + NADP(+) <=> [thioredoxin]-disulfide + H(+) + NADPH"}
{"X":1802,"KEGG":"R02017","RHEA_ID":28037,"DIRECTION":"BI","MASTER_ID":28034,"ecocyc":"ADPREDUCT-RXN","compounds":"[thioredoxin]-disulfide + dADP + H2O <=> [thioredoxin]-dithiol + ADP","pmd":15.995}
{"X":1803,"KEGG":"R02018","RHEA_ID":28029,"DIRECTION":"BI","MASTER_ID":28026,"compounds":"[thioredoxin]-disulfide + dUDP + H2O <=> [thioredoxin]-dithiol + UDP","pmd":15.995}
{"X":1804,"KEGG":"R02019","RHEA_ID":28033,"DIRECTION":"BI","MASTER_ID":28030,"compounds":"[thioredoxin]-disulfide + dGDP + H2O <=> [thioredoxin]-dithiol + GDP","pmd":15.995}
{"X":1805,"KEGG":"R02021","RHEA_ID":11727,"DIRECTION":"BI","MASTER_ID":11724,"metacyc":"1.8.4.8-RXN","compounds":"[thioredoxin]-disulfide + adenosine 3',5'-bisphosphate + 2 H(+) + sulfite <=> 3'-phosphoadenylyl sulfate + [thioredoxin]-dithiol","pmd":79.957}
{"X":1806,"KEGG":"R02024","RHEA_ID":28041,"DIRECTION":"BI","MASTER_ID":28038,"compounds":"[thioredoxin]-disulfide + dCDP + H2O <=> [thioredoxin]-dithiol + CDP","pmd":15.995}
{"X":1807,"KEGG":"R02029","RHEA_ID":33754,"DIRECTION":"BI","MASTER_ID":33751,"compounds":"1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate"}
{"X":1808,"KEGG":"R02030","RHEA_ID":32934,"DIRECTION":"BI","MASTER_ID":32931,"compounds":"1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a CDP-1,2-diacyl-sn-glycerol <=> a cardiolipin + CMP + H(+)"}
{"X":1809,"KEGG":"R02032","RHEA_ID":16824,"DIRECTION":"BI","MASTER_ID":16821,"compounds":"6-phospho-D-gluconate + NAD(+) <=> 6-phospho-2-dehydro-D-gluconate + H(+) + NADH","pmd":390.108}
{"X":1810,"KEGG":"R02032","RHEA_ID":16824,"DIRECTION":"BI","MASTER_ID":16821,"compounds":"6-phospho-D-gluconate + NAD(+) <=> 6-phospho-2-dehydro-D-gluconate + H(+) + NADH","pmd":2.016}
{"X":1811,"KEGG":"R02034","RHEA_ID":16820,"DIRECTION":"BI","MASTER_ID":16817,"compounds":"6-phospho-D-gluconate + NADP(+) <=> 6-phospho-2-dehydro-D-gluconate + H(+) + NADPH","pmd":2.016}
{"X":1812,"KEGG":"R02034","RHEA_ID":16820,"DIRECTION":"BI","MASTER_ID":16817,"compounds":"6-phospho-D-gluconate + NADP(+) <=> 6-phospho-2-dehydro-D-gluconate + H(+) + NADPH","pmd":470.074}
{"X":1813,"KEGG":"R02035","RHEA_ID":12559,"DIRECTION":"BI","MASTER_ID":12556,"compounds":"6-phospho-D-glucono-1,5-lactone + H2O <=> 6-phospho-D-gluconate + H(+)","pmd":18.011}
{"X":1814,"KEGG":"R02036","RHEA_ID":17280,"DIRECTION":"BI","MASTER_ID":17277,"compounds":"6-phospho-D-gluconate <=> 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O","pmd":18.011}
{"X":1815,"KEGG":"R02037","RHEA_ID":20368,"DIRECTION":"BI","MASTER_ID":20365,"compounds":"phosphoethanolamine + S-adenosyl-L-methionine <=> H(+) + N-methylethanolamine phosphate + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":1816,"KEGG":"R02038","RHEA_ID":24595,"DIRECTION":"BI","MASTER_ID":24592,"compounds":"CTP + H(+) + phosphoethanolamine <=> CDP-ethanolamine + diphosphate","pmd":36.924}
{"X":1817,"KEGG":"R02038","RHEA_ID":24595,"DIRECTION":"BI","MASTER_ID":24592,"compounds":"CTP + H(+) + phosphoethanolamine <=> CDP-ethanolamine + diphosphate","pmd":305.041}
{"X":1818,"KEGG":"R02039","RHEA_ID":10655,"DIRECTION":"BI","MASTER_ID":10652,"metacyc":"LONG-CHAIN-ALDEHYDE-DEHYDROGENASE-RXN","compounds":"a long-chain fatty aldehyde + H2O + NAD(+) <=> a long-chain fatty acid + 2 H(+) + NADH"}
{"X":1819,"KEGG":"R02040","RHEA_ID":17520,"DIRECTION":"BI","MASTER_ID":17517,"compounds":"H2O + N-(long-chain-fatty-acyl)-L-glutamate <=> a long-chain fatty acid + L-glutamate"}
{"X":1820,"KEGG":"R02041","RHEA_ID":17508,"DIRECTION":"BI","MASTER_ID":17505,"compounds":"H2O + N-(long-chain fatty acyl)ethanolamine <=> a long-chain fatty acid + ethanolamine"}
{"X":1821,"KEGG":"R02042","RHEA_ID":13580,"DIRECTION":"BI","MASTER_ID":13577,"compounds":"a wax ester + H2O <=> a long chain fatty alcohol + a long-chain fatty acid + H(+)"}
{"X":1822,"KEGG":"R02047","RHEA_ID":17684,"DIRECTION":"BI","MASTER_ID":17681,"compounds":"3-hydroxy-2-methylpropanoate + NAD(+) <=> 2-methyl-3-oxopropanoate + H(+) + NADH","pmd":2.016}
{"X":1823,"KEGG":"R02047","RHEA_ID":17684,"DIRECTION":"BI","MASTER_ID":17681,"compounds":"3-hydroxy-2-methylpropanoate + NAD(+) <=> 2-methyl-3-oxopropanoate + H(+) + NADH","pmd":562.085}
{"X":1824,"KEGG":"R02050","RHEA_ID":18396,"DIRECTION":"BI","MASTER_ID":18393,"metacyc":"2.6.1.40-RXN","compounds":"(R)-3-amino-2-methylpropanoate + pyruvate <=> 2-methyl-3-oxopropanoate + L-alanine","pmd":1.032}
{"X":1825,"KEGG":"R02055","RHEA_ID":20831,"DIRECTION":"BI","MASTER_ID":20828,"compounds":"1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2"}
{"X":1826,"KEGG":"R02056","RHEA_ID":11167,"DIRECTION":"BI","MASTER_ID":11164,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine <=> 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":1827,"KEGG":"R02057","RHEA_ID":32946,"DIRECTION":"BI","MASTER_ID":32943,"compounds":"a 1,2-diacyl-sn-glycerol + CDP-ethanolamine <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)","pmd":123.009}
{"X":1828,"KEGG":"R02058","RHEA_ID":10295,"DIRECTION":"BI","MASTER_ID":10292,"compounds":"acetyl-CoA + D-glucosamine 6-phosphate <=> CoA + H(+) + N-acetyl-D-glucosamine 6-phosphate","pmd":42.011}
{"X":1829,"KEGG":"R02059","RHEA_ID":22939,"DIRECTION":"BI","MASTER_ID":22936,"compounds":"H2O + N-acetyl-D-glucosamine 6-phosphate <=> acetate + D-glucosamine 6-phosphate","pmd":42.011}
{"X":1830,"KEGG":"R02060","RHEA_ID":23427,"DIRECTION":"BI","MASTER_ID":23424,"ecocyc":"5.4.2.10-RXN","metacyc":"5.4.2.10-RXN","compounds":"alpha-D-glucosamine 1-phosphate <=> D-glucosamine 6-phosphate","pmd":0}
{"X":1831,"KEGG":"R02061","RHEA_ID":17656,"DIRECTION":"BI","MASTER_ID":17653,"compounds":"(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate <=> all-trans-geranylgeranyl diphosphate + diphosphate","pmd":68.063}
{"X":1832,"KEGG":"R02061","RHEA_ID":17656,"DIRECTION":"BI","MASTER_ID":17653,"compounds":"(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate <=> all-trans-geranylgeranyl diphosphate + diphosphate","pmd":204.188}
{"X":1833,"KEGG":"R02064","RHEA_ID":14904,"DIRECTION":"BI","MASTER_ID":14901,"compounds":"all-trans-geranylgeranyl diphosphate <=> casbene + diphosphate","pmd":177.943}
{"X":1834,"KEGG":"R02065","RHEA_ID":22299,"DIRECTION":"BI","MASTER_ID":22296,"compounds":"2 all-trans-geranylgeranyl diphosphate <=> (1R,2R,3R)-prephytoene diphosphate + diphosphate","pmd":272.25}
{"X":1835,"KEGG":"R02068","RHEA_ID":14844,"DIRECTION":"BI","MASTER_ID":14841,"compounds":"all-trans-geranylgeranyl diphosphate <=> ent-copalyl diphosphate","pmd":0}
{"X":1836,"KEGG":"R02071","RHEA_ID":14216,"DIRECTION":"BI","MASTER_ID":14213,"compounds":"ATP + beta-D-fructose 1-phosphate <=> ADP + beta-D-fructose 1,6-bisphosphate + H(+)","pmd":79.966}
{"X":1837,"KEGG":"R02075","RHEA_ID":21223,"DIRECTION":"BI","MASTER_ID":21220,"metacyc":"STIZOLOBATE-SYNTHASE-RXN","compounds":"L-dopa + O2 <=> 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)","pmd":31.99}
{"X":1838,"KEGG":"R02076","RHEA_ID":18468,"DIRECTION":"BI","MASTER_ID":18465,"compounds":"L-dopa + O2 <=> 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)","pmd":31.99}
{"X":1839,"KEGG":"R02077","RHEA_ID":15276,"DIRECTION":"BI","MASTER_ID":15273,"metacyc":"2.6.1.49-RXN","compounds":"2-oxoglutarate + L-dopa <=> 3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate","pmd":1.032}
{"X":1840,"KEGG":"R02080","RHEA_ID":12275,"DIRECTION":"BI","MASTER_ID":12272,"compounds":"H(+) + L-dopa <=> CO2 + dopamine","pmd":43.99}
{"X":1841,"KEGG":"R02081","RHEA_ID":14836,"DIRECTION":"BI","MASTER_ID":14833,"compounds":"(R)-mevalonate + CoA + 2 NAD(+) <=> (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH","pmd":247.041}
{"X":1842,"KEGG":"R02081","RHEA_ID":14836,"DIRECTION":"BI","MASTER_ID":14833,"compounds":"(R)-mevalonate + CoA + 2 NAD(+) <=> (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH","pmd":517.051}
{"X":1843,"KEGG":"R02081","RHEA_ID":14836,"DIRECTION":"BI","MASTER_ID":14833,"compounds":"(R)-mevalonate + CoA + 2 NAD(+) <=> (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH","pmd":101.99}
{"X":1844,"KEGG":"R02082","RHEA_ID":15992,"DIRECTION":"BI","MASTER_ID":15989,"metacyc":"1.1.1.34-RXN","compounds":"(R)-mevalonate + CoA + 2 NADP(+) <=> (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH","pmd":22.024}
{"X":1845,"KEGG":"R02082","RHEA_ID":15992,"DIRECTION":"BI","MASTER_ID":15989,"metacyc":"1.1.1.34-RXN","compounds":"(R)-mevalonate + CoA + 2 NADP(+) <=> (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH","pmd":167.074}
{"X":1846,"KEGG":"R02082","RHEA_ID":15992,"DIRECTION":"BI","MASTER_ID":15989,"metacyc":"1.1.1.34-RXN","compounds":"(R)-mevalonate + CoA + 2 NADP(+) <=> (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH","pmd":597.017}
{"X":1847,"KEGG":"R02083","RHEA_ID":16308,"DIRECTION":"BI","MASTER_ID":16305,"compounds":"(3S)-hydroxy-3-methylglutaryl-CoA + H2O <=> 3-hydroxy-3-methylglutarate + CoA + H(+)","pmd":144.042}
{"X":1848,"KEGG":"R02084","RHEA_ID":12287,"DIRECTION":"BI","MASTER_ID":12284,"metacyc":"2.8.3.13-RXN","compounds":"3-hydroxy-3-methylglutarate + succinyl-CoA <=> (3S)-hydroxy-3-methylglutaryl-CoA + succinate","pmd":44.026}
{"X":1849,"KEGG":"R02085","RHEA_ID":21539,"DIRECTION":"BI","MASTER_ID":21536,"metacyc":"METHYLGLUTACONYL-COA-HYDRATASE-RXN","compounds":"(3S)-hydroxy-3-methylglutaryl-CoA <=> H2O + trans-3-methylglutaconyl-CoA","pmd":18.011}
{"X":1850,"KEGG":"R02087","RHEA_ID":25260,"DIRECTION":"BI","MASTER_ID":25257,"ecocyc":"NANE-RXN","compounds":"N-acetyl-D-glucosamine 6-phosphate <=> N-acetyl-D-mannosamine 6-phosphate","pmd":0}
{"X":1851,"KEGG":"R02088","RHEA_ID":29374,"DIRECTION":"BI","MASTER_ID":29371,"compounds":"dAMP + H2O <=> 2'-deoxyadenosine + phosphate","pmd":79.966}
{"X":1852,"KEGG":"R02089","RHEA_ID":23455,"DIRECTION":"BI","MASTER_ID":23452,"compounds":"2'-deoxyadenosine + ATP <=> ADP + dAMP + H(+)","pmd":79.966}
{"X":1853,"KEGG":"R02090","RHEA_ID":12700,"DIRECTION":"BI","MASTER_ID":12697,"compounds":"ATP + dGMP <=> ADP + dGDP","pmd":79.966}
{"X":1854,"KEGG":"R02093","RHEA_ID":27685,"DIRECTION":"BI","MASTER_ID":27682,"compounds":"ATP + dTDP <=> ADP + dTTP","pmd":25.007}
{"X":1855,"KEGG":"R02093","RHEA_ID":27685,"DIRECTION":"BI","MASTER_ID":27682,"compounds":"ATP + dTDP <=> ADP + dTTP","pmd":25.006}
{"X":1856,"KEGG":"R02094","RHEA_ID":13520,"DIRECTION":"BI","MASTER_ID":13517,"compounds":"ATP + dTMP <=> ADP + dTDP","pmd":79.966}
{"X":1857,"KEGG":"R02095","RHEA_ID":19016,"DIRECTION":"BI","MASTER_ID":19013,"compounds":"dTTP + H2O <=> dTDP + H(+) + phosphate","pmd":79.966}
{"X":1858,"KEGG":"R02098","RHEA_ID":30658,"DIRECTION":"BI","MASTER_ID":30655,"compounds":"ATP + dUMP <=> ADP + dUDP","pmd":79.966}
{"X":1859,"KEGG":"R02099","RHEA_ID":28209,"DIRECTION":"BI","MASTER_ID":28206,"compounds":"2'-deoxyuridine + ATP <=> ADP + dUMP + H(+)","pmd":79.966}
{"X":1860,"KEGG":"R02100","RHEA_ID":10251,"DIRECTION":"BI","MASTER_ID":10248,"compounds":"dUTP + H2O <=> diphosphate + dUMP + H(+)","pmd":159.933}
{"X":1861,"KEGG":"R02101","RHEA_ID":12107,"DIRECTION":"BI","MASTER_ID":12104,"compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP <=> 7,8-dihydrofolate + dTMP","pmd":14.016}
{"X":1862,"KEGG":"R02102","RHEA_ID":29358,"DIRECTION":"BI","MASTER_ID":29355,"compounds":"dUMP + H2O <=> 2'-deoxyuridine + phosphate","pmd":79.966}
{"X":1863,"KEGG":"R02103","RHEA_ID":16672,"DIRECTION":"BI","MASTER_ID":16669,"metacyc":"RXN0-901","compounds":"H2O + NAD(+) + xanthine <=> H(+) + NADH + urate","pmd":15.995}
{"X":1864,"KEGG":"R02103","RHEA_ID":16672,"DIRECTION":"BI","MASTER_ID":16669,"metacyc":"RXN0-901","compounds":"H2O + NAD(+) + xanthine <=> H(+) + NADH + urate","pmd":496.089}
{"X":1865,"KEGG":"R02106","RHEA_ID":21371,"DIRECTION":"BI","MASTER_ID":21368,"compounds":"H2O + O2 + urate <=> 5-hydroxyisourate + H2O2","pmd":15.995}
{"X":1866,"KEGG":"R02107","RHEA_ID":21135,"DIRECTION":"BI","MASTER_ID":21132,"compounds":"H2O + O2 + xanthine <=> H2O2 + urate","pmd":15.995}
{"X":1867,"KEGG":"R02113","RHEA_ID":22727,"DIRECTION":"BI","MASTER_ID":22724,"compounds":"a sterol + UDP-alpha-D-glucose <=> a sterol 3-beta-D-glucoside + H(+) + UDP","pmd":155.788}
{"X":1868,"KEGG":"R02114","RHEA_ID":21207,"DIRECTION":"BI","MASTER_ID":21204,"metacyc":"2.3.1.43-RXN","compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + a sterol <=> a 1-acyl-sn-glycero-3-phosphocholine + a sterol ester"}
{"X":1869,"KEGG":"R02115","RHEA_ID":10103,"DIRECTION":"BI","MASTER_ID":10100,"compounds":"a sterol ester + H2O <=> a fatty acid + a sterol + H(+)"}
{"X":1870,"KEGG":"R02118","RHEA_ID":23227,"DIRECTION":"BI","MASTER_ID":23224,"compounds":"trans-zeatin + UDP-alpha-D-glucose <=> H(+) + O-beta-D-glucosyl-trans-zeatin + UDP","pmd":162.053}
{"X":1871,"KEGG":"R02119","RHEA_ID":14724,"DIRECTION":"BI","MASTER_ID":14721,"metacyc":"ZEATIN-O-BETA-D-XYLOSYLTRANSFERASE-RXN","compounds":"UDP-alpha-D-xylose + zeatin <=> H(+) + O-beta-D-xylosylzeatin + UDP","pmd":132.042}
{"X":1872,"KEGG":"R02120","RHEA_ID":18828,"DIRECTION":"BI","MASTER_ID":18825,"metacyc":"2.4.1.125-RXN","compounds":"[(1->6)-alpha-D-glucosyl](n) + sucrose <=> [(1->6)-alpha-D-glucosyl](n+1) + D-fructose","pmd":162.053}
{"X":1873,"KEGG":"R02121","RHEA_ID":14628,"DIRECTION":"BI","MASTER_ID":14625,"compounds":"[(1->4)-alpha-D-glucosyl](n) + [(1->6)-alpha-D-glucosyl](n+1) <=> [(1->4)-alpha-D-glucosyl](n+1) + [(1->6)-alpha-D-glucosyl](n)"}
{"X":1874,"KEGG":"R02123","RHEA_ID":42083,"DIRECTION":"BI","MASTER_ID":42080,"metacyc":"RETINAL-DEHYDROGENASE-RXN","compounds":"all-trans-retinal + H2O + NAD(+) <=> all-trans-retinoate + 2 H(+) + NADH","pmd":15.995}
{"X":1875,"KEGG":"R02123","RHEA_ID":42083,"DIRECTION":"BI","MASTER_ID":42080,"metacyc":"RETINAL-DEHYDROGENASE-RXN","compounds":"all-trans-retinal + H2O + NAD(+) <=> all-trans-retinoate + 2 H(+) + NADH","pmd":363.908}
{"X":1876,"KEGG":"R02124","RHEA_ID":21287,"DIRECTION":"BI","MASTER_ID":21284,"metacyc":"RETINOL-DEHYDROGENASE-RXN","compounds":"all-trans-retinol + NAD(+) <=> all-trans-retinal + H(+) + NADH","pmd":379.903}
{"X":1877,"KEGG":"R02124","RHEA_ID":21287,"DIRECTION":"BI","MASTER_ID":21284,"metacyc":"RETINOL-DEHYDROGENASE-RXN","compounds":"all-trans-retinol + NAD(+) <=> all-trans-retinal + H(+) + NADH","pmd":2.016}
{"X":1878,"KEGG":"R02125","RHEA_ID":22523,"DIRECTION":"BI","MASTER_ID":22520,"compounds":"all-trans-retinal + H2O + O2 <=> all-trans-retinoate + H(+) + H2O2","pmd":15.995}
{"X":1879,"KEGG":"R02126","RHEA_ID":24127,"DIRECTION":"BI","MASTER_ID":24124,"metacyc":"RETINAL-ISOMERASE-RXN","compounds":"all-trans-retinal <=> 11-cis-retinal","pmd":0}
{"X":1880,"KEGG":"R02132","RHEA_ID":21283,"DIRECTION":"BI","MASTER_ID":21280,"compounds":"H2O + 2 O2 + thiamine <=> H(+) + 2 H2O2 + thiamine acetate","pmd":13.979}
{"X":1881,"KEGG":"R02133","RHEA_ID":17512,"DIRECTION":"BI","MASTER_ID":17509,"compounds":"H2O + thiamine <=> 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+)","pmd":122.072}
{"X":1882,"KEGG":"R02134","RHEA_ID":12015,"DIRECTION":"BI","MASTER_ID":12012,"compounds":"ATP + thiamine <=> ADP + H(+) + thiamine phosphate","pmd":79.966}
{"X":1883,"KEGG":"R02135","RHEA_ID":47951,"DIRECTION":"BI","MASTER_ID":47948,"compounds":"H2O + thiamine phosphate <=> phosphate + thiamine","pmd":79.966}
{"X":1884,"KEGG":"R02136","RHEA_ID":20212,"DIRECTION":"BI","MASTER_ID":20209,"compounds":"ATP + xylitol <=> ADP + H(+) + xylitol 5-phosphate","pmd":79.966}
{"X":1885,"KEGG":"R02137","RHEA_ID":27961,"DIRECTION":"BI","MASTER_ID":27958,"compounds":"cytidine + H2O <=> cytosine + D-ribose","pmd":93.033}
{"X":1886,"KEGG":"R02138","RHEA_ID":16688,"DIRECTION":"BI","MASTER_ID":16685,"compounds":"di-trans,poly-cis-dolichol + hexadecanoyl-CoA <=> CoA + dolichyl hexadecanoate"}
{"X":1887,"KEGG":"R02139","RHEA_ID":18656,"DIRECTION":"BI","MASTER_ID":18653,"compounds":"barbiturate + H2O <=> 3-oxo-3-ureidopropanoate","pmd":18.011}
{"X":1888,"KEGG":"R02142","RHEA_ID":10803,"DIRECTION":"BI","MASTER_ID":10800,"compounds":"diphosphate + XMP <=> 5-phospho-alpha-D-ribose 1-diphosphate + xanthine","pmd":25.91}
{"X":1889,"KEGG":"R02143","RHEA_ID":27997,"DIRECTION":"BI","MASTER_ID":27994,"compounds":"H2O + xanthosine <=> D-ribose + xanthine","pmd":132.042}
{"X":1890,"KEGG":"R02144","RHEA_ID":14208,"DIRECTION":"BI","MASTER_ID":14205,"compounds":"carnosine + S-adenosyl-L-methionine <=> anserine + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":1891,"KEGG":"R02145","RHEA_ID":12864,"DIRECTION":"BI","MASTER_ID":12861,"compounds":"guanosine + H(+) + H2O <=> NH4(+) + xanthosine","pmd":0.984}
{"X":1892,"KEGG":"R02147","RHEA_ID":13236,"DIRECTION":"BI","MASTER_ID":13233,"ecocyc":"RXN0-5199","metacyc":"RXN0-5199","compounds":"guanosine + phosphate <=> alpha-D-ribose 1-phosphate + guanine","pmd":53.072}
{"X":1893,"KEGG":"R02148","RHEA_ID":27865,"DIRECTION":"BI","MASTER_ID":27862,"metacyc":"RXN-14124","compounds":"3'-GMP + H2O <=> guanosine + phosphate","pmd":79.966}
{"X":1894,"KEGG":"R02150","RHEA_ID":25628,"DIRECTION":"BI","MASTER_ID":25625,"compounds":"H2O + histamine + O2 <=> H2O2 + imidazole-4-acetaldehyde + NH4(+)","pmd":1.032}
{"X":1895,"KEGG":"R02155","RHEA_ID":19304,"DIRECTION":"BI","MASTER_ID":19301,"compounds":"histamine + S-adenosyl-L-methionine <=> H(+) + N(tau)-methylhistamine + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":1896,"KEGG":"R02156","RHEA_ID":15384,"DIRECTION":"BI","MASTER_ID":15381,"ecocyc":"QUERCETIN-23-DIOXYGENASE-RXN","metacyc":"QUERCETIN-23-DIOXYGENASE-RXN","compounds":"O2 + quercetin <=> 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO","pmd":3.995}
{"X":1897,"KEGG":"R02157","RHEA_ID":17676,"DIRECTION":"BI","MASTER_ID":17673,"compounds":"quercetin + S-adenosyl-L-methionine <=> 3',4',5,7-tetrahydroxy-3-methoxyflavone + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":1898,"KEGG":"R02158","RHEA_ID":61183,"DIRECTION":"BI","MASTER_ID":61180,"compounds":"quercetin + UDP-alpha-D-glucose <=> H(+) + quercetin 3-O-beta-D-glucoside + UDP","pmd":101.959}
{"X":1899,"KEGG":"R02159","RHEA_ID":13456,"DIRECTION":"BI","MASTER_ID":13453,"compounds":"3'-phosphoadenylyl sulfate + quercetin <=> adenosine 3',5'-bisphosphate + H(+) + quercetin 3-sulfate","pmd":79.957}
{"X":1900,"KEGG":"R02160","RHEA_ID":61139,"DIRECTION":"BI","MASTER_ID":61136,"compounds":"(2R,3R)-dihydroquercetin + 2-oxoglutarate + O2 <=> CO2 + H(+) + H2O + quercetin + succinate","pmd":27.995}
{"X":1901,"KEGG":"R02160","RHEA_ID":61139,"DIRECTION":"BI","MASTER_ID":61136,"compounds":"(2R,3R)-dihydroquercetin + 2-oxoglutarate + O2 <=> CO2 + H(+) + H2O + quercetin + succinate","pmd":2.016}
{"X":1902,"KEGG":"R02161","RHEA_ID":11487,"DIRECTION":"BI","MASTER_ID":11484,"compounds":"2 [Fe(III)cytochrome c](out) + a quinol <=> 2 [Fe(II)cytochrome c](out) + a quinone + 2 H(+)(out)"}
{"X":1903,"KEGG":"R02163","RHEA_ID":23155,"DIRECTION":"BI","MASTER_ID":23152,"compounds":"a ubiquinone + H(+) + NADH <=> a ubiquinol + NAD(+)"}
{"X":1904,"KEGG":"R02164","RHEA_ID":40526,"DIRECTION":"BI","MASTER_ID":40523,"compounds":"a quinone + succinate <=> a quinol + fumarate","pmd":2.016}
{"X":1905,"KEGG":"R02164","RHEA_ID":13716,"DIRECTION":"BI","MASTER_ID":13713,"compounds":"a ubiquinone + succinate <=> a ubiquinol + fumarate","pmd":2.016}
{"X":1906,"KEGG":"R02165","RHEA_ID":29122,"DIRECTION":"BI","MASTER_ID":29119,"compounds":"a ubiquinol + nitrate <=> a ubiquinone + H2O + nitrite"}
{"X":1907,"KEGG":"R02167","RHEA_ID":19540,"DIRECTION":"BI","MASTER_ID":19537,"compounds":"D-mannitol 1-phosphate + H2O <=> D-mannitol + phosphate","pmd":79.966}
{"X":1908,"KEGG":"R02168","RHEA_ID":14608,"DIRECTION":"BI","MASTER_ID":14605,"compounds":"D-glucose 6-phosphate + GDP-alpha-D-glucose <=> alpha,alpha-trehalose 6-phosphate + GDP + H(+)","pmd":162.053}
{"X":1909,"KEGG":"R02170","RHEA_ID":18696,"DIRECTION":"BI","MASTER_ID":18693,"compounds":"H2O + penicillin <=> 6-aminopenicillanate + a carboxylate"}
{"X":1910,"KEGG":"R02171","RHEA_ID":13428,"DIRECTION":"BI","MASTER_ID":13425,"compounds":"a pyrimidine ribonucleoside 5'-phosphate + H2O <=> a pyrimidine nucleobase + D-ribose 5-phosphate","pmd":63.035}
{"X":1911,"KEGG":"R02172","RHEA_ID":56819,"DIRECTION":"BI","MASTER_ID":56816,"compounds":"a pyrimidine ribonucleoside + H2O <=> a pyrimidine nucleobase + D-ribose","pmd":63.035}
{"X":1912,"KEGG":"R02173","RHEA_ID":59419,"DIRECTION":"BI","MASTER_ID":59416,"compounds":"H2O + O2 + tryptamine <=> H2O2 + indole-3-acetaldehyde + NH4(+)","pmd":1.032}
{"X":1913,"KEGG":"R02175","RHEA_ID":44403,"DIRECTION":"BI","MASTER_ID":44400,"compounds":"3-demethylubiquinol-6 + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + ubiquinol-6","pmd":14.016}
{"X":1914,"KEGG":"R02177","RHEA_ID":13920,"DIRECTION":"BI","MASTER_ID":13917,"compounds":"(-)-menthol + NADP(+) <=> (1R,4S)-menthone + H(+) + NADPH","pmd":589.947}
{"X":1915,"KEGG":"R02177","RHEA_ID":13920,"DIRECTION":"BI","MASTER_ID":13917,"compounds":"(-)-menthol + NADP(+) <=> (1R,4S)-menthone + H(+) + NADPH","pmd":2.016}
{"X":1916,"KEGG":"R02178","RHEA_ID":11651,"DIRECTION":"BI","MASTER_ID":11648,"compounds":"(-)-menthol + H(+) + NADPH + O2 <=> 1,4-menthane-3,8-diol + H2O + NADP(+)","pmd":15.995}
{"X":1917,"KEGG":"R02178","RHEA_ID":11651,"DIRECTION":"BI","MASTER_ID":11648,"compounds":"(-)-menthol + H(+) + NADPH + O2 <=> 1,4-menthane-3,8-diol + H2O + NADP(+)","pmd":572.945}
{"X":1918,"KEGG":"R02179","RHEA_ID":11523,"DIRECTION":"BI","MASTER_ID":11520,"compounds":"(-)-menthol + UDP-alpha-D-glucose <=> (-)-menthyl beta-D-glucoside + H(+) + UDP","pmd":162.053}
{"X":1919,"KEGG":"R02180","RHEA_ID":16104,"DIRECTION":"BI","MASTER_ID":16101,"compounds":"n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate <=> n adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate + n H(+)","pmd":79.957}
{"X":1920,"KEGG":"R02181","RHEA_ID":11111,"DIRECTION":"BI","MASTER_ID":11108,"compounds":"n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate <=> n adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate + 2 H(+)","pmd":79.957}
{"X":1921,"KEGG":"R02182","RHEA_ID":18288,"DIRECTION":"BI","MASTER_ID":18285,"compounds":"an N-acyl-D-aspartate + H2O <=> a carboxylate + D-aspartate"}
{"X":1922,"KEGG":"R02183","RHEA_ID":23959,"DIRECTION":"BI","MASTER_ID":23956,"compounds":"L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP","pmd":203.079}
{"X":1923,"KEGG":"R02184","RHEA_ID":19576,"DIRECTION":"BI","MASTER_ID":19573,"ecocyc":"POLYPHOSPHATE-KINASE-RXN","metacyc":"POLYPHOSPHATE-KINASE-RXN","compounds":"[phosphate](n) + ATP <=> [phosphate](n+1) + ADP","pmd":79.966}
{"X":1924,"KEGG":"R02185","RHEA_ID":22039,"DIRECTION":"BI","MASTER_ID":22036,"compounds":"[phosphate](n) + D-glucose <=> [phosphate](n-1) + D-glucose 6-phosphate + H(+)","pmd":79.966}
{"X":1925,"KEGG":"R02186","RHEA_ID":19420,"DIRECTION":"BI","MASTER_ID":19417,"compounds":"[phosphate](n) + dolichyl diphosphate <=> [phosphate](n+1) + dolichyl phosphate"}
{"X":1926,"KEGG":"R02188","RHEA_ID":18668,"DIRECTION":"BI","MASTER_ID":18665,"compounds":"(2R)-3-phospho-glyceroyl phosphate + [phosphate](n) <=> (2R)-3-phosphoglycerate + [phosphate](n+1)","pmd":79.966}
{"X":1927,"KEGG":"R02190","RHEA_ID":11003,"DIRECTION":"BI","MASTER_ID":11000,"metacyc":"3.5.1.77-RXN","compounds":"an N-carbamoyl-D-amino acid + 2 H(+) + H2O <=> a D-alpha-amino acid + CO2 + NH4(+)"}
{"X":1928,"KEGG":"R02191","RHEA_ID":20707,"DIRECTION":"BI","MASTER_ID":20704,"metacyc":"D-AMINO-ACID-N-ACETYLTRANSFERASE-RXN","compounds":"a D-alpha-amino acid + acetyl-CoA <=> an N-acetyl-D-amino acid + CoA + H(+)","pmd":42.011}
{"X":1929,"KEGG":"R02192","RHEA_ID":18312,"DIRECTION":"BI","MASTER_ID":18309,"compounds":"an N-acyl-D-amino acid + H2O <=> a carboxylate + a D-alpha-amino acid"}
{"X":1930,"KEGG":"R02194","RHEA_ID":36254,"DIRECTION":"BI","MASTER_ID":36251,"compounds":"ATP + CoA + trans-ferulate <=> (E)-feruloyl-CoA + AMP + diphosphate","pmd":159.933}
{"X":1931,"KEGG":"R02194","RHEA_ID":36254,"DIRECTION":"BI","MASTER_ID":36251,"compounds":"ATP + CoA + trans-ferulate <=> (E)-feruloyl-CoA + AMP + diphosphate","pmd":153.005}
{"X":1932,"KEGG":"R02194","RHEA_ID":36254,"DIRECTION":"BI","MASTER_ID":36251,"compounds":"ATP + CoA + trans-ferulate <=> (E)-feruloyl-CoA + AMP + diphosphate","pmd":176.047}
{"X":1933,"KEGG":"R02195","RHEA_ID":15024,"DIRECTION":"BI","MASTER_ID":15021,"compounds":"(E)-feruloyl-CoA + L-quinate <=> 4-O-feruloyl-D-quinate + CoA","pmd":176.047}
{"X":1934,"KEGG":"R02196","RHEA_ID":32962,"DIRECTION":"BI","MASTER_ID":32959,"compounds":"H2O + L-isoleucine + NAD(+) <=> (S)-3-methyl-2-oxopentanoate + H(+) + NADH + NH4(+)","pmd":534.054}
{"X":1935,"KEGG":"R02196","RHEA_ID":32962,"DIRECTION":"BI","MASTER_ID":32959,"compounds":"H2O + L-isoleucine + NAD(+) <=> (S)-3-methyl-2-oxopentanoate + H(+) + NADH + NH4(+)","pmd":1.032}
{"X":1936,"KEGG":"R02197","RHEA_ID":61235,"DIRECTION":"BI","MASTER_ID":61232,"compounds":"H2O + L-isoleucine + O2 <=> (S)-3-methyl-2-oxopentanoate + H2O2 + NH4(+)","pmd":1.032}
{"X":1937,"KEGG":"R02199","RHEA_ID":24804,"DIRECTION":"BI","MASTER_ID":24801,"ecocyc":"BRANCHED-CHAINAMINOTRANSFERILEU-RXN","metacyc":"BRANCHED-CHAINAMINOTRANSFERILEU-RXN","compounds":"2-oxoglutarate + L-isoleucine <=> (S)-3-methyl-2-oxopentanoate + L-glutamate","pmd":1.032}
{"X":1938,"KEGG":"R02200","RHEA_ID":11471,"DIRECTION":"BI","MASTER_ID":11468,"metacyc":"2.6.1.32-RXN","compounds":"(S)-3-methyl-2-oxopentanoate + L-valine <=> 3-methyl-2-oxobutanoate + L-isoleucine","pmd":1.032}
{"X":1939,"KEGG":"R02201","RHEA_ID":30810,"DIRECTION":"BI","MASTER_ID":30807,"compounds":"L-pipecolate + NAD(+) <=> Delta(1)-piperideine-2-carboxylate + H(+) + NADH","pmd":2.016}
{"X":1940,"KEGG":"R02201","RHEA_ID":30810,"DIRECTION":"BI","MASTER_ID":30807,"compounds":"L-pipecolate + NAD(+) <=> Delta(1)-piperideine-2-carboxylate + H(+) + NADH","pmd":537.054}
{"X":1941,"KEGG":"R02203","RHEA_ID":12527,"DIRECTION":"BI","MASTER_ID":12524,"compounds":"L-pipecolate + NADP(+) <=> Delta(1)-piperideine-2-carboxylate + H(+) + NADPH","pmd":617.02}
{"X":1942,"KEGG":"R02203","RHEA_ID":12527,"DIRECTION":"BI","MASTER_ID":12524,"compounds":"L-pipecolate + NADP(+) <=> Delta(1)-piperideine-2-carboxylate + H(+) + NADPH","pmd":2.016}
{"X":1943,"KEGG":"R02204","RHEA_ID":11995,"DIRECTION":"BI","MASTER_ID":11992,"compounds":"L-pipecolate + O2 <=> H(+) + H2O2 + L-1-piperideine-6-carboxylate","pmd":2.016}
{"X":1944,"KEGG":"R02206","RHEA_ID":19780,"DIRECTION":"BI","MASTER_ID":19777,"compounds":"A + L-pipecolate <=> AH2 + H(+) + L-1-piperideine-6-carboxylate","pmd":2.016}
{"X":1945,"KEGG":"R02208","RHEA_ID":21955,"DIRECTION":"BI","MASTER_ID":21952,"compounds":"5alpha-pregnane-3,20-dione + NADP(+) <=> H(+) + NADPH + progesterone","pmd":2.016}
{"X":1946,"KEGG":"R02208","RHEA_ID":21955,"DIRECTION":"BI","MASTER_ID":21952,"compounds":"5alpha-pregnane-3,20-dione + NADP(+) <=> H(+) + NADPH + progesterone","pmd":429.859}
{"X":1947,"KEGG":"R02210","RHEA_ID":11703,"DIRECTION":"BI","MASTER_ID":11700,"compounds":"H(+) + NADPH + O2 + progesterone <=> H2O + NADP(+) + testosterone acetate","pmd":15.995}
{"X":1948,"KEGG":"R02210","RHEA_ID":11703,"DIRECTION":"BI","MASTER_ID":11700,"compounds":"H(+) + NADPH + O2 + progesterone <=> H2O + NADP(+) + testosterone acetate","pmd":414.872}
{"X":1949,"KEGG":"R02212","RHEA_ID":11987,"DIRECTION":"BI","MASTER_ID":11984,"compounds":"AH2 + O2 + progesterone <=> A + H2O + testosterone acetate","pmd":15.995}
{"X":1950,"KEGG":"R02214","RHEA_ID":18208,"DIRECTION":"BI","MASTER_ID":18205,"compounds":"AH2 + O2 + progesterone <=> 11alpha-hydroxyprogesterone + A + H2O","pmd":15.995}
{"X":1951,"KEGG":"R02222","RHEA_ID":19724,"DIRECTION":"BI","MASTER_ID":19721,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + octadecanoyl-CoA <=> (9Z)-octadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":1952,"KEGG":"R02223","RHEA_ID":13300,"DIRECTION":"BI","MASTER_ID":13297,"compounds":"3 H(+) + malonyl-CoA + 2 NADH + octadecanoyl-CoA <=> CO2 + CoA + eicosanoyl-CoA + H2O + 2 NAD(+)"}
{"X":1953,"KEGG":"R02224","RHEA_ID":13296,"DIRECTION":"BI","MASTER_ID":13293,"compounds":"3 H(+) + malonyl-CoA + 2 NADPH + octadecanoyl-CoA <=> CO2 + CoA + eicosanoyl-CoA + H2O + 2 NADP(+)","pmd":86}
{"X":1954,"KEGG":"R02224","RHEA_ID":13296,"DIRECTION":"BI","MASTER_ID":13293,"compounds":"3 H(+) + malonyl-CoA + 2 NADPH + octadecanoyl-CoA <=> CO2 + CoA + eicosanoyl-CoA + H2O + 2 NADP(+)","pmd":22.024}
{"X":1955,"KEGG":"R02225","RHEA_ID":22271,"DIRECTION":"BI","MASTER_ID":22268,"compounds":"ATP + streptomycin <=> ADP + H(+) + streptomycin 6-phosphate","pmd":79.966}
{"X":1956,"KEGG":"R02226","RHEA_ID":20248,"DIRECTION":"BI","MASTER_ID":20245,"metacyc":"STREPTOMYCIN-3-ADENYLYLTRANSFERASE-RXN","compounds":"ATP + streptomycin <=> 3''-adenylylstreptomycin + diphosphate","pmd":403.323}
{"X":1957,"KEGG":"R02226","RHEA_ID":20248,"DIRECTION":"BI","MASTER_ID":20245,"metacyc":"STREPTOMYCIN-3-ADENYLYLTRANSFERASE-RXN","compounds":"ATP + streptomycin <=> 3''-adenylylstreptomycin + diphosphate","pmd":329.053}
{"X":1958,"KEGG":"R02227","RHEA_ID":18380,"DIRECTION":"BI","MASTER_ID":18377,"metacyc":"STREPTOMYCIN-3-KINASE-RXN","compounds":"ATP + streptomycin <=> ADP + H(+) + streptomycin 3''-phosphate","pmd":79.966}
{"X":1959,"KEGG":"R02228","RHEA_ID":10691,"DIRECTION":"BI","MASTER_ID":10688,"compounds":"H2O + streptomycin 6-phosphate <=> phosphate + streptomycin","pmd":79.966}
{"X":1960,"KEGG":"R02229","RHEA_ID":10047,"DIRECTION":"BI","MASTER_ID":10044,"compounds":"cyclohexanol + NAD(+) <=> cyclohexanone + H(+) + NADH","pmd":565.036}
{"X":1961,"KEGG":"R02231","RHEA_ID":24071,"DIRECTION":"BI","MASTER_ID":24068,"compounds":"cyclohexanone + H(+) + NADPH + O2 <=> H2O + hexano-6-lactone + NADP(+)","pmd":631.023}
{"X":1962,"KEGG":"R02232","RHEA_ID":23871,"DIRECTION":"BI","MASTER_ID":23868,"compounds":"(1-hydroxycyclohexan-1-yl)acetyl-CoA <=> acetyl-CoA + cyclohexanone","pmd":98.073}
{"X":1963,"KEGG":"R02233","RHEA_ID":18436,"DIRECTION":"BI","MASTER_ID":18433,"compounds":"cyclohexylamine + H2O + O2 <=> cyclohexanone + H2O2 + NH4(+)"}
{"X":1964,"KEGG":"R02236","RHEA_ID":31106,"DIRECTION":"BI","MASTER_ID":31103,"compounds":"7,8-dihydrofolate + NADP(+) <=> folate + H(+) + NADPH","pmd":302.944}
{"X":1965,"KEGG":"R02236","RHEA_ID":31106,"DIRECTION":"BI","MASTER_ID":31103,"compounds":"7,8-dihydrofolate + NADP(+) <=> folate + H(+) + NADPH","pmd":2.016}
{"X":1966,"KEGG":"R02237","RHEA_ID":23587,"DIRECTION":"BI","MASTER_ID":23584,"compounds":"7,8-dihydropteroate + ATP + L-glutamate <=> 7,8-dihydrofolate + ADP + H(+) + phosphate","pmd":279.976}
{"X":1967,"KEGG":"R02237","RHEA_ID":23587,"DIRECTION":"BI","MASTER_ID":23584,"compounds":"7,8-dihydropteroate + ATP + L-glutamate <=> 7,8-dihydrofolate + ADP + H(+) + phosphate","pmd":63.84}
{"X":1968,"KEGG":"R02237","RHEA_ID":23587,"DIRECTION":"BI","MASTER_ID":23584,"compounds":"7,8-dihydropteroate + ATP + L-glutamate <=> 7,8-dihydrofolate + ADP + H(+) + phosphate","pmd":112.917}
{"X":1969,"KEGG":"R02238","RHEA_ID":24331,"DIRECTION":"BI","MASTER_ID":24328,"compounds":"7,8-dihydrofolate + ATP + formate <=> 10-formyldihydrofolate + ADP + phosphate","pmd":35.846}
{"X":1970,"KEGG":"R02238","RHEA_ID":24331,"DIRECTION":"BI","MASTER_ID":24328,"compounds":"7,8-dihydrofolate + ATP + formate <=> 10-formyldihydrofolate + ADP + phosphate","pmd":16.126}
{"X":1971,"KEGG":"R02239","RHEA_ID":27432,"DIRECTION":"BI","MASTER_ID":27429,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphate + H2O <=> a 1,2-diacyl-sn-glycerol + phosphate"}
{"X":1972,"KEGG":"R02240","RHEA_ID":10275,"DIRECTION":"BI","MASTER_ID":10272,"ecocyc":"DIACYLGLYKIN-RXN","metacyc":"DIACYLGLYKIN-RXN","compounds":"a 1,2-diacyl-sn-glycerol + ATP <=> a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)","pmd":79.966}
{"X":1973,"KEGG":"R02241","RHEA_ID":19712,"DIRECTION":"BI","MASTER_ID":19709,"compounds":"a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phosphate + CoA"}
{"X":1974,"KEGG":"R02242","RHEA_ID":14236,"DIRECTION":"BI","MASTER_ID":14233,"compounds":"a 2-acyl-sn-glycerol 3-phosphate + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phosphate + CoA"}
{"X":1975,"KEGG":"R02243","RHEA_ID":15256,"DIRECTION":"BI","MASTER_ID":15253,"compounds":"cis-aconitate + H(+) <=> CO2 + itaconate","pmd":43.99}
{"X":1976,"KEGG":"R02244","RHEA_ID":17268,"DIRECTION":"BI","MASTER_ID":17265,"ecocyc":"ACONITATE-DELTA-ISOMERASE-RXN","metacyc":"ACONITATE-DELTA-ISOMERASE-RXN","compounds":"trans-aconitate <=> cis-aconitate","pmd":0}
{"X":1977,"KEGG":"R02245","RHEA_ID":17068,"DIRECTION":"BI","MASTER_ID":17065,"metacyc":"MEVALONATE-KINASE-RXN","compounds":"(R)-mevalonate + ATP <=> (R)-5-phosphomevalonate + ADP + H(+)","pmd":79.966}
{"X":1978,"KEGG":"R02246","RHEA_ID":13224,"DIRECTION":"BI","MASTER_ID":13221,"compounds":"(R)-mevalonate + NAD(+) <=> H(+) + mevaldate + NADH","pmd":518.059}
{"X":1979,"KEGG":"R02246","RHEA_ID":13224,"DIRECTION":"BI","MASTER_ID":13221,"compounds":"(R)-mevalonate + NAD(+) <=> H(+) + mevaldate + NADH","pmd":2.016}
{"X":1980,"KEGG":"R02247","RHEA_ID":20196,"DIRECTION":"BI","MASTER_ID":20193,"compounds":"(R)-mevalonate + NADP(+) <=> H(+) + mevaldate + NADPH","pmd":2.016}
{"X":1981,"KEGG":"R02247","RHEA_ID":20196,"DIRECTION":"BI","MASTER_ID":20193,"compounds":"(R)-mevalonate + NADP(+) <=> H(+) + mevaldate + NADPH","pmd":598.025}
{"X":1982,"KEGG":"R02248","RHEA_ID":14116,"DIRECTION":"BI","MASTER_ID":14113,"compounds":"(DNA)-3'-(deoxyribonucleoside 3',5'-bisphosphate) + H2O <=> (DNA)-3'-(deoxyribonucleoside 5'-phosphate) + phosphate"}
{"X":1983,"KEGG":"R02251","RHEA_ID":10871,"DIRECTION":"BI","MASTER_ID":10868,"compounds":"a 1,2-diacyl-sn-glycerol + an acyl-CoA <=> a triacyl-sn-glycerol + CoA"}
{"X":1984,"KEGG":"R02252","RHEA_ID":50947,"DIRECTION":"BI","MASTER_ID":50944,"compounds":"3-phenylpropanoate + NAD(+) <=> H(+) + NADH + trans-cinnamate","pmd":516.064}
{"X":1985,"KEGG":"R02252","RHEA_ID":50947,"DIRECTION":"BI","MASTER_ID":50944,"compounds":"3-phenylpropanoate + NAD(+) <=> H(+) + NADH + trans-cinnamate","pmd":2.016}
{"X":1986,"KEGG":"R02253","RHEA_ID":10611,"DIRECTION":"BI","MASTER_ID":10608,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + trans-cinnamate <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + trans-4-coumarate","pmd":15.995}
{"X":1987,"KEGG":"R02254","RHEA_ID":10959,"DIRECTION":"BI","MASTER_ID":10956,"compounds":"H(+) + NADPH + O2 + trans-cinnamate <=> H2O + NADP(+) + trans-2-coumarate","pmd":15.995}
{"X":1988,"KEGG":"R02254","RHEA_ID":10959,"DIRECTION":"BI","MASTER_ID":10956,"compounds":"H(+) + NADPH + O2 + trans-cinnamate <=> H2O + NADP(+) + trans-2-coumarate","pmd":581.044}
{"X":1989,"KEGG":"R02256","RHEA_ID":13440,"DIRECTION":"BI","MASTER_ID":13437,"compounds":"trans-cinnamate + UDP-alpha-D-glucose <=> 1-O-(trans-cinnamoyl)-beta-D-glucose + UDP","pmd":162.053}
{"X":1990,"KEGG":"R02258","RHEA_ID":15936,"DIRECTION":"BI","MASTER_ID":15933,"ecocyc":"LACTALDREDUCT-RXN","metacyc":"LACTALDREDUCT-RXN","compounds":"(S)-propane-1,2-diol + NAD(+) <=> (S)-lactaldehyde + H(+) + NADH"}
{"X":1991,"KEGG":"R02259","RHEA_ID":15888,"DIRECTION":"BI","MASTER_ID":15885,"compounds":"NADP(+) + propane-1,2-diol <=> (S)-lactaldehyde + H(+) + NADPH"}
{"X":1992,"KEGG":"R02261","RHEA_ID":25787,"DIRECTION":"BI","MASTER_ID":25784,"metacyc":"RXN0-5433","compounds":"2-dehydro-3-deoxy-L-rhamnonate <=> (S)-lactaldehyde + pyruvate"}
{"X":1993,"KEGG":"R02262","RHEA_ID":12936,"DIRECTION":"BI","MASTER_ID":12933,"ecocyc":"FUCPALDOL-RXN","metacyc":"FUCPALDOL-RXN","compounds":"L-fuculose 1-phosphate <=> (S)-lactaldehyde + dihydroxyacetone phosphate","pmd":74.037}
{"X":1994,"KEGG":"R02263","RHEA_ID":19692,"DIRECTION":"BI","MASTER_ID":19689,"ecocyc":"RHAMNULPALDOL-RXN","metacyc":"RHAMNULPALDOL-RXN","compounds":"L-rhamnulose 1-phosphate <=> (S)-lactaldehyde + dihydroxyacetone phosphate","pmd":74.037}
{"X":1995,"KEGG":"R02265","RHEA_ID":12896,"DIRECTION":"BI","MASTER_ID":12893,"compounds":"prostaglandin H2 <=> prostaglandin E2","pmd":0}
{"X":1996,"KEGG":"R02266","RHEA_ID":10603,"DIRECTION":"BI","MASTER_ID":10600,"compounds":"prostaglandin H2 <=> prostaglandin D2","pmd":0}
{"X":1997,"KEGG":"R02267","RHEA_ID":23583,"DIRECTION":"BI","MASTER_ID":23580,"compounds":"prostaglandin H2 <=> prostaglandin I2","pmd":0}
{"X":1998,"KEGG":"R02268","RHEA_ID":17140,"DIRECTION":"BI","MASTER_ID":17137,"compounds":"prostaglandin H2 <=> thromboxane A2","pmd":0}
{"X":1999,"KEGG":"R02269","RHEA_ID":16124,"DIRECTION":"BI","MASTER_ID":16121,"metacyc":"DIHYDROPYRIMIDINASE-RXN","compounds":"5,6-dihydrouracil + H2O <=> 3-(carbamoylamino)propanoate + H(+)","pmd":18.011}
{"X":2000,"KEGG":"R02271","RHEA_ID":12483,"DIRECTION":"BI","MASTER_ID":12480,"metacyc":"AMINOLEVULINATE-AMINOTRANSFERASE-RXN","compounds":"5-aminolevulinate + pyruvate <=> 4,5-dioxopentanoate + L-alanine","pmd":1.032}
{"X":2001,"KEGG":"R02272","RHEA_ID":14268,"DIRECTION":"BI","MASTER_ID":14265,"compounds":"(S)-4-amino-5-oxopentanoate <=> 5-aminolevulinate","pmd":0}
{"X":2002,"KEGG":"R02273","RHEA_ID":15680,"DIRECTION":"BI","MASTER_ID":15677,"compounds":"5-aminopentanamide + H2O <=> 5-aminopentanoate + NH4(+)","pmd":0.984}
{"X":2003,"KEGG":"R02274","RHEA_ID":10215,"DIRECTION":"BI","MASTER_ID":10212,"metacyc":"VAGL-RXN","compounds":"2-oxoglutarate + 5-aminopentanoate <=> 5-oxopentanoate + L-glutamate","pmd":1.032}
{"X":2004,"KEGG":"R02276","RHEA_ID":42515,"DIRECTION":"BI","MASTER_ID":42512,"compounds":"5-acetamidopentanoate + H2O <=> 5-aminopentanoate + acetate","pmd":42.01}
{"X":2005,"KEGG":"R02277","RHEA_ID":23183,"DIRECTION":"BI","MASTER_ID":23180,"compounds":"a secondary alcohol + O2 <=> a ketone + H2O2"}
{"X":2006,"KEGG":"R02278","RHEA_ID":17204,"DIRECTION":"BI","MASTER_ID":17201,"compounds":"2-dehydro-3-deoxy-L-arabinonate <=> 2,5-dioxopentanoate + H2O","pmd":18.011}
{"X":2007,"KEGG":"R02279","RHEA_ID":24611,"DIRECTION":"BI","MASTER_ID":24608,"compounds":"5-dehydro-4-deoxy-D-glucarate + H(+) <=> 2,5-dioxopentanoate + CO2 + H2O","pmd":62}
{"X":2008,"KEGG":"R02280","RHEA_ID":10563,"DIRECTION":"BI","MASTER_ID":10560,"compounds":"4-hydroxy-1-pyrroline-2-carboxylate + H(+) + H2O <=> 2,5-dioxopentanoate + NH4(+)","pmd":0.984}
{"X":2009,"KEGG":"R02282","RHEA_ID":15352,"DIRECTION":"BI","MASTER_ID":15349,"compounds":"L-glutamate + N(2)-acetyl-L-ornithine <=> L-ornithine + N-acetyl-L-glutamate","pmd":14.963}
{"X":2010,"KEGG":"R02283","RHEA_ID":18052,"DIRECTION":"BI","MASTER_ID":18049,"ecocyc":"ACETYLORNTRANSAM-RXN","metacyc":"ACETYLORNTRANSAM-RXN","compounds":"2-oxoglutarate + N(2)-acetyl-L-ornithine <=> L-glutamate + N-acetyl-L-glutamate 5-semialdehyde","pmd":1.032}
{"X":2011,"KEGG":"R02284","RHEA_ID":12031,"DIRECTION":"BI","MASTER_ID":12028,"compounds":"H2O + L-5-carboxymethylhydantoin <=> H(+) + N-carbamoyl-L-aspartate","pmd":18.01}
{"X":2012,"KEGG":"R02285","RHEA_ID":22495,"DIRECTION":"BI","MASTER_ID":22492,"compounds":"H2O + N-formimidoyl-L-glutamate <=> formamide + L-glutamate","pmd":27.011}
{"X":2013,"KEGG":"R02286","RHEA_ID":22835,"DIRECTION":"BI","MASTER_ID":22832,"compounds":"H2O + N-formimidoyl-L-glutamate <=> N-formyl-L-glutamate + NH4(+)","pmd":0.984}
{"X":2014,"KEGG":"R02287","RHEA_ID":15100,"DIRECTION":"BI","MASTER_ID":15097,"compounds":"5-formimidoyltetrahydrofolate + L-glutamate <=> (6S)-5,6,7,8-tetrahydrofolate + N-formimidoyl-L-glutamate","pmd":27.011}
{"X":2015,"KEGG":"R02288","RHEA_ID":23663,"DIRECTION":"BI","MASTER_ID":23660,"compounds":"4-imidazolone-5-propanoate + H2O <=> N-formimidoyl-L-glutamate","pmd":18.011}
{"X":2016,"KEGG":"R02289","RHEA_ID":45203,"DIRECTION":"BI","MASTER_ID":45200,"metacyc":"METHCOCLTH-RXN","compounds":"(6S)-5,6,7,8-tetrahydrofolate + [methyl-Co(III) corrinoid Fe-S protein] <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + [Co(I) corrinoid Fe-S protein] + H(+)","pmd":14.016}
{"X":2017,"KEGG":"R02291","RHEA_ID":24287,"DIRECTION":"BI","MASTER_ID":24284,"ecocyc":"ASPARTATE-SEMIALDEHYDE-DEHYDROGENASE-RXN","metacyc":"ASPARTATE-SEMIALDEHYDE-DEHYDROGENASE-RXN","compounds":"L-aspartate 4-semialdehyde + NADP(+) + phosphate <=> 4-phospho-L-aspartate + H(+) + NADPH","pmd":95.961}
{"X":2018,"KEGG":"R02291","RHEA_ID":24287,"DIRECTION":"BI","MASTER_ID":24284,"ecocyc":"ASPARTATE-SEMIALDEHYDE-DEHYDROGENASE-RXN","metacyc":"ASPARTATE-SEMIALDEHYDE-DEHYDROGENASE-RXN","compounds":"L-aspartate 4-semialdehyde + NADP(+) + phosphate <=> 4-phospho-L-aspartate + H(+) + NADPH","pmd":531.08}
{"X":2019,"KEGG":"R02293","RHEA_ID":12383,"DIRECTION":"BI","MASTER_ID":12380,"metacyc":"2.6.1.46-RXN","compounds":"L-2,4-diaminobutanoate + pyruvate <=> L-alanine + L-aspartate 4-semialdehyde","pmd":1.032}
{"X":2020,"KEGG":"R02297","RHEA_ID":27641,"DIRECTION":"BI","MASTER_ID":27638,"compounds":"phosphate + xanthosine <=> alpha-D-ribose 1-phosphate + xanthine","pmd":54.056}
{"X":2021,"KEGG":"R02301","RHEA_ID":10491,"DIRECTION":"BI","MASTER_ID":10488,"compounds":"5-formyltetrahydrofolate + ATP <=> 5,10-methenyltetrahydrofolate + ADP + phosphate","pmd":50.832}
{"X":2022,"KEGG":"R02301","RHEA_ID":10491,"DIRECTION":"BI","MASTER_ID":10488,"compounds":"5-formyltetrahydrofolate + ATP <=> 5,10-methenyltetrahydrofolate + ADP + phosphate","pmd":17.003}
{"X":2023,"KEGG":"R02302","RHEA_ID":22739,"DIRECTION":"BI","MASTER_ID":22736,"compounds":"5-formimidoyltetrahydrofolate + 2 H(+) <=> 5,10-methenyltetrahydrofolate + NH4(+)","pmd":16.019}
{"X":2024,"KEGG":"R02303","RHEA_ID":21547,"DIRECTION":"BI","MASTER_ID":21544,"compounds":"(2E,6E)-farnesyl diphosphate + ATP <=> (2E,6E)-farnesyl triphosphate + ADP","pmd":44.898}
{"X":2025,"KEGG":"R02305","RHEA_ID":18084,"DIRECTION":"BI","MASTER_ID":18081,"compounds":"(2E,6E)-farnesyl diphosphate <=> diphosphate + pentalenene","pmd":177.943}
{"X":2026,"KEGG":"R02306","RHEA_ID":12055,"DIRECTION":"BI","MASTER_ID":12052,"compounds":"(2E,6E)-farnesyl diphosphate <=> diphosphate + trichodiene","pmd":177.943}
{"X":2027,"KEGG":"R02307","RHEA_ID":19828,"DIRECTION":"BI","MASTER_ID":19825,"compounds":"(2E,6E)-farnesyl diphosphate <=> (+)-aristolochene + diphosphate","pmd":177.943}
{"X":2028,"KEGG":"R02313","RHEA_ID":24523,"DIRECTION":"BI","MASTER_ID":24520,"compounds":"H2O + L-saccharopine + NAD(+) <=> (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADH","pmd":517.064}
{"X":2029,"KEGG":"R02313","RHEA_ID":24523,"DIRECTION":"BI","MASTER_ID":24520,"compounds":"H2O + L-saccharopine + NAD(+) <=> (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADH","pmd":129.079}
{"X":2030,"KEGG":"R02315","RHEA_ID":10023,"DIRECTION":"BI","MASTER_ID":10020,"compounds":"H2O + L-saccharopine + NADP(+) <=> (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADPH","pmd":129.079}
{"X":2031,"KEGG":"R02315","RHEA_ID":10023,"DIRECTION":"BI","MASTER_ID":10020,"compounds":"H2O + L-saccharopine + NADP(+) <=> (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADPH","pmd":597.03}
{"X":2032,"KEGG":"R02317","RHEA_ID":25124,"DIRECTION":"BI","MASTER_ID":25121,"metacyc":"RXN-8173","compounds":"(S)-2-amino-6-oxohexanoate <=> H(+) + H2O + L-1-piperideine-6-carboxylate","pmd":18.011}
{"X":2033,"KEGG":"R02318","RHEA_ID":10823,"DIRECTION":"BI","MASTER_ID":10820,"compounds":"D-threo-isocitrate <=> D-erythro-isocitrate","pmd":0}
{"X":2034,"KEGG":"R02319","RHEA_ID":23683,"DIRECTION":"BI","MASTER_ID":23680,"compounds":"a ribonucleoside 5'-triphosphate + H2O <=> a ribonucleoside 5'-diphosphate + H(+) + phosphate"}
{"X":2035,"KEGG":"R02320","RHEA_ID":56963,"DIRECTION":"BI","MASTER_ID":56960,"compounds":"a ribonucleoside 5'-triphosphate + pyruvate <=> a ribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate"}
{"X":2036,"KEGG":"R02321","RHEA_ID":20064,"DIRECTION":"BI","MASTER_ID":20061,"compounds":"2'-deoxycytidine + a ribonucleoside 5'-triphosphate <=> a ribonucleoside 5'-diphosphate + dCMP + H(+)","pmd":79.966}
{"X":2037,"KEGG":"R02322","RHEA_ID":12403,"DIRECTION":"BI","MASTER_ID":12400,"compounds":"beta-nicotinamide D-ribonucleotide + H2O <=> NH4(+) + nicotinate beta-D-ribonucleotide","pmd":1.992}
{"X":2038,"KEGG":"R02323","RHEA_ID":30818,"DIRECTION":"BI","MASTER_ID":30815,"compounds":"beta-nicotinamide D-ribonucleotide + H2O <=> beta-nicotinamide D-riboside + phosphate","pmd":78.959}
{"X":2039,"KEGG":"R02324","RHEA_ID":14020,"DIRECTION":"BI","MASTER_ID":14017,"compounds":"ATP + beta-nicotinamide D-riboside <=> ADP + beta-nicotinamide D-ribonucleotide + H(+)","pmd":79.966}
{"X":2040,"KEGG":"R02324","RHEA_ID":14020,"DIRECTION":"BI","MASTER_ID":14017,"compounds":"ATP + beta-nicotinamide D-riboside <=> ADP + beta-nicotinamide D-ribonucleotide + H(+)","pmd":78.959}
{"X":2041,"KEGG":"R02325","RHEA_ID":22683,"DIRECTION":"BI","MASTER_ID":22680,"compounds":"dCTP + H(+) + H2O <=> dUTP + NH4(+)","pmd":0.984}
{"X":2042,"KEGG":"R02326","RHEA_ID":27681,"DIRECTION":"BI","MASTER_ID":27678,"compounds":"ATP + dCDP <=> ADP + dCTP","pmd":40.006}
{"X":2043,"KEGG":"R02328","RHEA_ID":15228,"DIRECTION":"BI","MASTER_ID":15225,"ecocyc":"DTDPGLUCOSEPP-RXN","metacyc":"DTDPGLUCOSEPP-RXN","compounds":"alpha-D-glucose 1-phosphate + dTTP + H(+) <=> diphosphate + dTDP-alpha-D-glucose","pmd":82.086}
{"X":2044,"KEGG":"R02328","RHEA_ID":15228,"DIRECTION":"BI","MASTER_ID":15225,"ecocyc":"DTDPGLUCOSEPP-RXN","metacyc":"DTDPGLUCOSEPP-RXN","compounds":"alpha-D-glucose 1-phosphate + dTTP + H(+) <=> diphosphate + dTDP-alpha-D-glucose","pmd":304.046}
{"X":2045,"KEGG":"R02329","RHEA_ID":17168,"DIRECTION":"BI","MASTER_ID":17165,"compounds":"alpha-D-galactose 1-phosphate + dTTP + H(+) <=> diphosphate + dTDP-D-galactose","pmd":82.086}
{"X":2046,"KEGG":"R02329","RHEA_ID":17168,"DIRECTION":"BI","MASTER_ID":17165,"compounds":"alpha-D-galactose 1-phosphate + dTTP + H(+) <=> diphosphate + dTDP-D-galactose","pmd":304.046}
{"X":2047,"KEGG":"R02331","RHEA_ID":28585,"DIRECTION":"BI","MASTER_ID":28582,"compounds":"ATP + dUDP <=> ADP + dUTP","pmd":39.022}
{"X":2048,"KEGG":"R02333","RHEA_ID":10467,"DIRECTION":"BI","MASTER_ID":10464,"compounds":"[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O <=> n acetate + chitosan"}
{"X":2049,"KEGG":"R02335","RHEA_ID":16640,"DIRECTION":"BI","MASTER_ID":16637,"compounds":"[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine <=> [(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + H(+) + UDP","pmd":203.079}
{"X":2050,"KEGG":"R02336","RHEA_ID":11047,"DIRECTION":"BI","MASTER_ID":11044,"metacyc":"HALOACETATE-DEHALOGENASE-RXN","compounds":"a haloacetate + H2O <=> a halide anion + glycolate + H(+)"}
{"X":2051,"KEGG":"R02337","RHEA_ID":19084,"DIRECTION":"BI","MASTER_ID":19081,"compounds":"1-haloalkane + H2O <=> a halide anion + a primary alcohol + H(+)"}
{"X":2052,"KEGG":"R02338","RHEA_ID":11215,"DIRECTION":"BI","MASTER_ID":11212,"compounds":"indole + O2 <=> 2-formamidobenzaldehyde","pmd":31.99}
{"X":2053,"KEGG":"R02340","RHEA_ID":14084,"DIRECTION":"BI","MASTER_ID":14081,"ecocyc":"RXN0-2381","metacyc":"RXN0-2381","compounds":"(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate <=> D-glyceraldehyde 3-phosphate + indole","pmd":117.058}
{"X":2054,"KEGG":"R02341","RHEA_ID":23347,"DIRECTION":"BI","MASTER_ID":23344,"compounds":"a purine D-ribonucleoside + H2O <=> a purine nucleobase + D-ribose","pmd":102.033}
{"X":2055,"KEGG":"R02343","RHEA_ID":22903,"DIRECTION":"BI","MASTER_ID":22900,"compounds":"(R)-acetoin + NAD(+) <=> diacetyl + H(+) + NADH"}
{"X":2056,"KEGG":"R02345","RHEA_ID":21507,"DIRECTION":"BI","MASTER_ID":21504,"compounds":"acetoin + aldehydo-D-ribose 5-phosphate <=> 1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde","pmd":44.026}
{"X":2057,"KEGG":"R02347","RHEA_ID":16704,"DIRECTION":"BI","MASTER_ID":16701,"compounds":"17alpha-estradiol + NAD(+) <=> estrone + H(+) + NADH","pmd":393.955}
{"X":2058,"KEGG":"R02347","RHEA_ID":16704,"DIRECTION":"BI","MASTER_ID":16701,"compounds":"17alpha-estradiol + NAD(+) <=> estrone + H(+) + NADH","pmd":2.016}
{"X":2059,"KEGG":"R02349","RHEA_ID":16708,"DIRECTION":"BI","MASTER_ID":16705,"compounds":"17alpha-estradiol + NADP(+) <=> estrone + H(+) + NADPH","pmd":473.921}
{"X":2060,"KEGG":"R02349","RHEA_ID":16708,"DIRECTION":"BI","MASTER_ID":16705,"compounds":"17alpha-estradiol + NADP(+) <=> estrone + H(+) + NADPH","pmd":2.016}
{"X":2061,"KEGG":"R02350","RHEA_ID":15976,"DIRECTION":"BI","MASTER_ID":15973,"metacyc":"ESTRONE-SULFOTRANSFERASE-RXN","compounds":"3'-phosphoadenylyl sulfate + estrone <=> adenosine 3',5'-bisphosphate + estrone 3-sulfate + H(+)","pmd":79.957}
{"X":2062,"KEGG":"R02351","RHEA_ID":38210,"DIRECTION":"BI","MASTER_ID":38207,"compounds":"19-oxo-androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] <=> estrone + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":30.011}
{"X":2063,"KEGG":"R02352","RHEA_ID":24615,"DIRECTION":"BI","MASTER_ID":24612,"compounds":"17beta-estradiol + NAD(+) <=> estrone + H(+) + NADH","pmd":393.955}
{"X":2064,"KEGG":"R02352","RHEA_ID":24615,"DIRECTION":"BI","MASTER_ID":24612,"compounds":"17beta-estradiol + NAD(+) <=> estrone + H(+) + NADH","pmd":2.016}
{"X":2065,"KEGG":"R02353","RHEA_ID":24619,"DIRECTION":"BI","MASTER_ID":24616,"compounds":"17beta-estradiol + NADP(+) <=> estrone + H(+) + NADPH","pmd":2.016}
{"X":2066,"KEGG":"R02353","RHEA_ID":24619,"DIRECTION":"BI","MASTER_ID":24616,"compounds":"17beta-estradiol + NADP(+) <=> estrone + H(+) + NADPH","pmd":473.921}
{"X":2067,"KEGG":"R02359","RHEA_ID":21375,"DIRECTION":"BI","MASTER_ID":21372,"compounds":"H(+) + H2O + urethane <=> CO2 + ethanol + NH4(+)"}
{"X":2068,"KEGG":"R02361","RHEA_ID":57107,"DIRECTION":"BI","MASTER_ID":57104,"compounds":"[(1->4)-alpha-D-galacturonosyl](n) <=> 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate + [(1->4)-alpha-D-galacturonosyl](n-2)"}
{"X":2069,"KEGG":"R02362","RHEA_ID":22383,"DIRECTION":"BI","MASTER_ID":22380,"compounds":"[(1->4)-alpha-D-galacturonosyl methyl ester](n) + n H2O <=> [(1->4)-alpha-D-galacturonosyl](n) + n H(+) + n methanol"}
{"X":2070,"KEGG":"R02363","RHEA_ID":55379,"DIRECTION":"BI","MASTER_ID":55376,"compounds":"2 a quinol + O2 <=> 2 a quinone + 2 H2O","pmd":2.016}
{"X":2071,"KEGG":"R02364","RHEA_ID":14272,"DIRECTION":"BI","MASTER_ID":14269,"ecocyc":"QOR-RXN","metacyc":"QOR-RXN","compounds":"2 a quinone + H(+) + NADPH <=> 2 a 1,4-benzosemiquinone + NADP(+)"}
{"X":2072,"KEGG":"R02366","RHEA_ID":11491,"DIRECTION":"BI","MASTER_ID":11488,"metacyc":"RETINOL-O-FATTY-ACYLTRANSFERASE-RXN","compounds":"all-trans-retinol + an acyl-CoA <=> an all-trans-retinyl ester + CoA","pmd":480.885}
{"X":2073,"KEGG":"R02368","RHEA_ID":21511,"DIRECTION":"BI","MASTER_ID":21508,"compounds":"all-trans-retinyl hexadecanoate + H2O <=> H(+) + hexadecanoate + retinol","pmd":238.23}
{"X":2074,"KEGG":"R02368","RHEA_ID":13936,"DIRECTION":"BI","MASTER_ID":13933,"compounds":"all-trans-retinyl hexadecanoate + H2O <=> all-trans-retinol + H(+) + hexadecanoate","pmd":238.23}
{"X":2075,"KEGG":"R02369","RHEA_ID":19144,"DIRECTION":"BI","MASTER_ID":19141,"metacyc":"RETINOL-ISOMERASE-RXN","compounds":"all-trans-retinol <=> 11-cis-retinol","pmd":0}
{"X":2076,"KEGG":"R02370","RHEA_ID":27897,"DIRECTION":"BI","MASTER_ID":27894,"compounds":"3'-CMP + H2O <=> cytidine + phosphate","pmd":79.966}
{"X":2077,"KEGG":"R02373","RHEA_ID":11799,"DIRECTION":"BI","MASTER_ID":11796,"compounds":"ecdysone + O2 <=> 3-dehydroecdysone + H2O2","pmd":2.016}
{"X":2078,"KEGG":"R02374","RHEA_ID":14024,"DIRECTION":"BI","MASTER_ID":14021,"compounds":"AH2 + ecdysone + O2 <=> 20-hydroxyecdysone + A + H2O","pmd":15.995}
{"X":2079,"KEGG":"R02375","RHEA_ID":15220,"DIRECTION":"BI","MASTER_ID":15217,"compounds":"ecdysone + hexadecanoyl-CoA <=> CoA + ecdysone hexadecanoate","pmd":238.23}
{"X":2080,"KEGG":"R02376","RHEA_ID":14572,"DIRECTION":"BI","MASTER_ID":14569,"compounds":"propane-1,2-diol <=> H2O + propanal"}
{"X":2081,"KEGG":"R02377","RHEA_ID":50707,"DIRECTION":"BI","MASTER_ID":50704,"metacyc":"RXN-13198","compounds":"1-propanol + NAD(+) <=> H(+) + NADH + propanal"}
{"X":2082,"KEGG":"R02378","RHEA_ID":24515,"DIRECTION":"BI","MASTER_ID":24512,"metacyc":"PYRAZOLYLALANINE-SYNTHASE-RXN","compounds":"L-serine + pyrazole <=> 3-(pyrazol-1-yl)-L-alanine + H2O","pmd":50.027}
{"X":2083,"KEGG":"R02379","RHEA_ID":60955,"DIRECTION":"BI","MASTER_ID":60952,"compounds":"(E)-5-hydroxyferulate + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + trans-sinapate","pmd":14.016}
{"X":2084,"KEGG":"R02380","RHEA_ID":13308,"DIRECTION":"BI","MASTER_ID":13305,"compounds":"trans-sinapate + UDP-alpha-D-glucose <=> 1-O-(trans-sinapoyl)-beta-D-glucose + UDP","pmd":162.053}
{"X":2085,"KEGG":"R02381","RHEA_ID":10019,"DIRECTION":"BI","MASTER_ID":10016,"compounds":"H2O + O-sinapoylcholine <=> choline + H(+) + trans-sinapate","pmd":86.097}
{"X":2086,"KEGG":"R02382","RHEA_ID":30594,"DIRECTION":"BI","MASTER_ID":30591,"compounds":"H2O + O2 + tyramine <=> (4-hydroxyphenyl)acetaldehyde + H2O2 + NH4(+)","pmd":1.032}
{"X":2087,"KEGG":"R02384","RHEA_ID":14868,"DIRECTION":"BI","MASTER_ID":14865,"compounds":"S-adenosyl-L-methionine + tyramine <=> H(+) + N-methyltyramine + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":2088,"KEGG":"R02385","RHEA_ID":19688,"DIRECTION":"BI","MASTER_ID":19685,"metacyc":"TYRAMINE-N-FERULOYLTRANSFERASE-RXN","compounds":"(E)-feruloyl-CoA + tyramine <=> CoA + H(+) + N-[(E)-feruloyl]tyramine","pmd":176.047}
{"X":2089,"KEGG":"R02391","RHEA_ID":15800,"DIRECTION":"BI","MASTER_ID":15797,"compounds":"bilirubin IXalpha + NAD(+) <=> biliverdin IXalpha + H(+) + NADH","pmd":2.016}
{"X":2090,"KEGG":"R02391","RHEA_ID":15800,"DIRECTION":"BI","MASTER_ID":15797,"compounds":"bilirubin IXalpha + NAD(+) <=> biliverdin IXalpha + H(+) + NADH","pmd":81.869}
{"X":2091,"KEGG":"R02393","RHEA_ID":15796,"DIRECTION":"BI","MASTER_ID":15793,"compounds":"bilirubin IXalpha + NADP(+) <=> biliverdin IXalpha + H(+) + NADPH","pmd":2.016}
{"X":2092,"KEGG":"R02393","RHEA_ID":15796,"DIRECTION":"BI","MASTER_ID":15793,"compounds":"bilirubin IXalpha + NADP(+) <=> biliverdin IXalpha + H(+) + NADPH","pmd":161.836}
{"X":2093,"KEGG":"R02394","RHEA_ID":20983,"DIRECTION":"BI","MASTER_ID":20980,"compounds":"2 bilirubin IXalpha + O2 <=> 2 biliverdin IXalpha + 2 H2O","pmd":2.016}
{"X":2094,"KEGG":"R02395","RHEA_ID":19268,"DIRECTION":"BI","MASTER_ID":19265,"metacyc":"CARNITINE-3-DEHYDROGENASE-RXN","compounds":"carnitine + NAD(+) <=> 3-dehydrocarnitine + H(+) + NADH","pmd":2.016}
{"X":2095,"KEGG":"R02395","RHEA_ID":19268,"DIRECTION":"BI","MASTER_ID":19265,"metacyc":"CARNITINE-3-DEHYDROGENASE-RXN","compounds":"carnitine + NAD(+) <=> 3-dehydrocarnitine + H(+) + NADH","pmd":504.019}
{"X":2096,"KEGG":"R02396","RHEA_ID":21139,"DIRECTION":"BI","MASTER_ID":21136,"metacyc":"CARNITINE-O-ACETYLTRANSFERASE-RXN","compounds":"(R)-carnitine + acetyl-CoA <=> CoA + O-acetyl-(R)-carnitine","pmd":42.011}
{"X":2097,"KEGG":"R02397","RHEA_ID":24031,"DIRECTION":"BI","MASTER_ID":24028,"compounds":"2-oxoglutarate + 4-(trimethylamino)butanoate + O2 <=> carnitine + CO2 + succinate","pmd":15.995}
{"X":2098,"KEGG":"R02397","RHEA_ID":24031,"DIRECTION":"BI","MASTER_ID":24028,"compounds":"2-oxoglutarate + 4-(trimethylamino)butanoate + O2 <=> carnitine + CO2 + succinate","pmd":16.091}
{"X":2099,"KEGG":"R02398","RHEA_ID":21579,"DIRECTION":"BI","MASTER_ID":21576,"compounds":"carnitine + H(+) <=> 2-methylcholine + CO2","pmd":43.99}
{"X":2100,"KEGG":"R02401","RHEA_ID":12067,"DIRECTION":"BI","MASTER_ID":12064,"compounds":"5-oxopentanoate + H2O + NAD(+) <=> glutarate + 2 H(+) + NADH","pmd":532.075}
{"X":2101,"KEGG":"R02401","RHEA_ID":12067,"DIRECTION":"BI","MASTER_ID":12064,"compounds":"5-oxopentanoate + H2O + NAD(+) <=> glutarate + 2 H(+) + NADH","pmd":15.995}
{"X":2102,"KEGG":"R02402","RHEA_ID":14172,"DIRECTION":"BI","MASTER_ID":14169,"compounds":"ATP + CoA + glutarate <=> ADP + glutaryl-CoA + phosphate","pmd":294.987}
{"X":2103,"KEGG":"R02402","RHEA_ID":14172,"DIRECTION":"BI","MASTER_ID":14169,"compounds":"ATP + CoA + glutarate <=> ADP + glutaryl-CoA + phosphate","pmd":79.966}
{"X":2104,"KEGG":"R02402","RHEA_ID":14172,"DIRECTION":"BI","MASTER_ID":14169,"compounds":"ATP + CoA + glutarate <=> ADP + glutaryl-CoA + phosphate","pmd":114.032}
{"X":2105,"KEGG":"R02407","RHEA_ID":38286,"DIRECTION":"BI","MASTER_ID":38283,"compounds":"itaconate + succinyl-CoA <=> itaconyl-CoA + succinate","pmd":12}
{"X":2106,"KEGG":"R02408","RHEA_ID":24930,"DIRECTION":"BI","MASTER_ID":24927,"compounds":"H2O + L-cystine <=> NH4(+) + pyruvate + S-sulfanyl-L-cysteine","pmd":87.032}
{"X":2107,"KEGG":"R02411","RHEA_ID":20164,"DIRECTION":"BI","MASTER_ID":20161,"compounds":"alpha-D-galactosyl-(1->3)-1D-myo-inositol + sucrose <=> myo-inositol + raffinose","pmd":162.053}
{"X":2108,"KEGG":"R02412","RHEA_ID":13124,"DIRECTION":"BI","MASTER_ID":13121,"metacyc":"SHIKIMATE-KINASE-RXN","compounds":"ATP + shikimate <=> 3-phosphoshikimate + ADP + H(+)","pmd":79.966}
{"X":2109,"KEGG":"R02413","RHEA_ID":17740,"DIRECTION":"BI","MASTER_ID":17737,"compounds":"NADP(+) + shikimate <=> 3-dehydroshikimate + H(+) + NADPH","pmd":2.016}
{"X":2110,"KEGG":"R02413","RHEA_ID":17740,"DIRECTION":"BI","MASTER_ID":17737,"compounds":"NADP(+) + shikimate <=> 3-dehydroshikimate + H(+) + NADPH","pmd":572.046}
{"X":2111,"KEGG":"R02416","RHEA_ID":12127,"DIRECTION":"BI","MASTER_ID":12124,"compounds":"4-coumaroyl-CoA + shikimate <=> CoA + trans-4-coumaroylshikimate","pmd":146.037}
{"X":2112,"KEGG":"R02417","RHEA_ID":10839,"DIRECTION":"BI","MASTER_ID":10836,"compounds":"NADPH + O2 + questin <=> demethylsulochrin + NADP(+)","pmd":34.006}
{"X":2113,"KEGG":"R02417","RHEA_ID":10839,"DIRECTION":"BI","MASTER_ID":10836,"compounds":"NADPH + O2 + questin <=> demethylsulochrin + NADP(+)","pmd":427.017}
{"X":2114,"KEGG":"R02419","RHEA_ID":23695,"DIRECTION":"BI","MASTER_ID":23692,"metacyc":"MALEATE-HYDRATASE-RXN","compounds":"(R)-malate <=> H2O + maleate","pmd":18.011}
{"X":2115,"KEGG":"R02421","RHEA_ID":18192,"DIRECTION":"BI","MASTER_ID":18189,"ecocyc":"GLYCOGENSYN-RXN","metacyc":"GLYCOGENSYN-RXN","compounds":"[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose <=> [(1->4)-alpha-D-glucosyl](n+1) + ADP + H(+)","pmd":162.053}
{"X":2116,"KEGG":"R02422","RHEA_ID":11019,"DIRECTION":"BI","MASTER_ID":11016,"compounds":"allantoate + H2O <=> (S)-ureidoglycolate + urea","pmd":42.022}
{"X":2117,"KEGG":"R02423","RHEA_ID":13596,"DIRECTION":"BI","MASTER_ID":13593,"compounds":"allantoate + 2 H(+) + H2O <=> CO2 + NH4(+) + ureidoglycine","pmd":43.006}
{"X":2118,"KEGG":"R02423","RHEA_ID":27488,"DIRECTION":"BI","MASTER_ID":27485,"compounds":"allantoate + 2 H(+) + H2O <=> (S)-2-ureidoglycine + CO2 + NH4(+)","pmd":43.006}
{"X":2119,"KEGG":"R02424","RHEA_ID":30822,"DIRECTION":"BI","MASTER_ID":30819,"compounds":"allantoin + H2O <=> allantoate + H(+)"}
{"X":2120,"KEGG":"R02425","RHEA_ID":17032,"DIRECTION":"BI","MASTER_ID":17029,"compounds":"(S)-allantoin + H2O <=> allantoate + H(+)","pmd":18.011}
{"X":2121,"KEGG":"R02426","RHEA_ID":17156,"DIRECTION":"BI","MASTER_ID":17153,"compounds":"CDP-D-glucose <=> CDP-4-dehydro-6-deoxy-D-glucose + H2O","pmd":18.011}
{"X":2122,"KEGG":"R02427","RHEA_ID":59331,"DIRECTION":"BI","MASTER_ID":59328,"compounds":"D-xylono-1,5-lactone + H2O <=> D-xylonate + H(+)","pmd":18.01}
{"X":2123,"KEGG":"R02428","RHEA_ID":18344,"DIRECTION":"BI","MASTER_ID":18341,"compounds":"D-xylono-1,4-lactone + H2O <=> D-xylonate + H(+)","pmd":18.01}
{"X":2124,"KEGG":"R02429","RHEA_ID":19160,"DIRECTION":"BI","MASTER_ID":19157,"ecocyc":"XYLONATE-DEHYDRATASE-RXN","compounds":"D-xylonate <=> 2-dehydro-3-deoxy-D-arabinonate + H2O","pmd":18.01}
{"X":2125,"KEGG":"R02430","RHEA_ID":20711,"DIRECTION":"BI","MASTER_ID":20708,"compounds":"ATP + erythritol <=> ADP + D-erythritol 4-phosphate + H(+)","pmd":79.966}
{"X":2126,"KEGG":"R02436","RHEA_ID":17468,"DIRECTION":"BI","MASTER_ID":17465,"compounds":"H2O + quercitrin <=> L-rhamnopyranose + quercetin","pmd":146.058}
{"X":2127,"KEGG":"R02437","RHEA_ID":23163,"DIRECTION":"BI","MASTER_ID":23160,"ecocyc":"RHAMNISOM-RXN","metacyc":"RHAMNISOM-RXN","compounds":"L-rhamnopyranose <=> L-rhamnulose","pmd":0}
{"X":2128,"KEGG":"R02439","RHEA_ID":22075,"DIRECTION":"BI","MASTER_ID":22072,"compounds":"ATP + L-ribulose <=> ADP + H(+) + L-ribulose 5-phosphate","pmd":79.966}
{"X":2129,"KEGG":"R02441","RHEA_ID":21359,"DIRECTION":"BI","MASTER_ID":21356,"compounds":"L-arabinitol + NAD(+) <=> H(+) + L-ribulose + NADH","pmd":2.016}
{"X":2130,"KEGG":"R02441","RHEA_ID":21359,"DIRECTION":"BI","MASTER_ID":21356,"compounds":"L-arabinitol + NAD(+) <=> H(+) + L-ribulose + NADH","pmd":514.064}
{"X":2131,"KEGG":"R02442","RHEA_ID":61099,"DIRECTION":"BI","MASTER_ID":61096,"compounds":"(S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-eriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":2132,"KEGG":"R02444","RHEA_ID":61087,"DIRECTION":"BI","MASTER_ID":61084,"compounds":"(S)-naringenin + 2-oxoglutarate + O2 <=> (2R,3R)-dihydrokaempferol + CO2 + succinate","pmd":27.995}
{"X":2133,"KEGG":"R02444","RHEA_ID":61087,"DIRECTION":"BI","MASTER_ID":61084,"compounds":"(S)-naringenin + 2-oxoglutarate + O2 <=> (2R,3R)-dihydrokaempferol + CO2 + succinate","pmd":15.995}
{"X":2134,"KEGG":"R02445","RHEA_ID":32758,"DIRECTION":"BI","MASTER_ID":32755,"compounds":"(S)-naringenin + 2-oxoglutarate + O2 <=> apigenin + CO2 + H(+) + H2O + succinate","pmd":2.016}
{"X":2135,"KEGG":"R02445","RHEA_ID":32758,"DIRECTION":"BI","MASTER_ID":32755,"compounds":"(S)-naringenin + 2-oxoglutarate + O2 <=> apigenin + CO2 + H(+) + H2O + succinate","pmd":27.995}
{"X":2136,"KEGG":"R02447","RHEA_ID":35146,"DIRECTION":"BI","MASTER_ID":35143,"compounds":"benzoyl-CoA + 2 H(+) + 3 malonyl-CoA <=> 2,4,6-trihydroxybenzophenone + 3 CO2 + 4 CoA","pmd":86}
{"X":2137,"KEGG":"R02447","RHEA_ID":35146,"DIRECTION":"BI","MASTER_ID":35143,"compounds":"benzoyl-CoA + 2 H(+) + 3 malonyl-CoA <=> 2,4,6-trihydroxybenzophenone + 3 CO2 + 4 CoA","pmd":104.026}
{"X":2138,"KEGG":"R02449","RHEA_ID":23219,"DIRECTION":"BI","MASTER_ID":23216,"compounds":"benzoyl-CoA + H(+) + NADPH + O2 <=> 3-hydroxybenzoyl-CoA + H2O + NADP(+)","pmd":142.045}
{"X":2139,"KEGG":"R02449","RHEA_ID":23219,"DIRECTION":"BI","MASTER_ID":23216,"compounds":"benzoyl-CoA + H(+) + NADPH + O2 <=> 3-hydroxybenzoyl-CoA + H2O + NADP(+)","pmd":15.995}
{"X":2140,"KEGG":"R02450","RHEA_ID":10375,"DIRECTION":"BI","MASTER_ID":10372,"metacyc":"1.2.1.58-RXN","compounds":"CoA + NAD(+) + phenylglyoxylate <=> benzoyl-CoA + CO2 + NADH","pmd":207.024}
{"X":2141,"KEGG":"R02450","RHEA_ID":10375,"DIRECTION":"BI","MASTER_ID":10372,"metacyc":"1.2.1.58-RXN","compounds":"CoA + NAD(+) + phenylglyoxylate <=> benzoyl-CoA + CO2 + NADH","pmd":101.99}
{"X":2142,"KEGG":"R02450","RHEA_ID":10375,"DIRECTION":"BI","MASTER_ID":10372,"metacyc":"1.2.1.58-RXN","compounds":"CoA + NAD(+) + phenylglyoxylate <=> benzoyl-CoA + CO2 + NADH","pmd":515.093}
{"X":2143,"KEGG":"R02451","RHEA_ID":30202,"DIRECTION":"BI","MASTER_ID":30199,"metacyc":"1.3.99.15-RXN","compounds":"2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate <=> 2 ATP + benzoyl-CoA + 2 H2O + reduced 2[4Fe-4S]-[ferredoxin]","pmd":79.966}
{"X":2144,"KEGG":"R02451","RHEA_ID":30202,"DIRECTION":"BI","MASTER_ID":30199,"metacyc":"1.3.99.15-RXN","compounds":"2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate <=> 2 ATP + benzoyl-CoA + 2 H2O + reduced 2[4Fe-4S]-[ferredoxin]","pmd":2.016}
{"X":2145,"KEGG":"R02451","RHEA_ID":19100,"DIRECTION":"BI","MASTER_ID":19097,"metacyc":"1.3.99.15-RXN","compounds":"AH2 + 2 ATP + benzoyl-CoA + 2 H2O <=> A + 2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + 2 H(+) + 2 phosphate","pmd":79.966}
{"X":2146,"KEGG":"R02451","RHEA_ID":19100,"DIRECTION":"BI","MASTER_ID":19097,"metacyc":"1.3.99.15-RXN","compounds":"AH2 + 2 ATP + benzoyl-CoA + 2 H2O <=> A + 2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + 2 H(+) + 2 phosphate","pmd":2.016}
{"X":2147,"KEGG":"R02452","RHEA_ID":18496,"DIRECTION":"BI","MASTER_ID":18493,"compounds":"benzoyl-CoA + glycine <=> CoA + H(+) + N-benzoylglycine","pmd":104.026}
{"X":2148,"KEGG":"R02453","RHEA_ID":21603,"DIRECTION":"BI","MASTER_ID":21600,"compounds":"anthranilate + benzoyl-CoA <=> CoA + N-benzoylanthranilate","pmd":104.026}
{"X":2149,"KEGG":"R02454","RHEA_ID":15732,"DIRECTION":"BI","MASTER_ID":15729,"ecocyc":"MANNONOXIDOREDUCT-RXN","metacyc":"MANNONOXIDOREDUCT-RXN","compounds":"D-mannonate + NAD(+) <=> H(+) + keto-D-fructuronate + NADH","pmd":2.016}
{"X":2150,"KEGG":"R02454","RHEA_ID":15732,"DIRECTION":"BI","MASTER_ID":15729,"ecocyc":"MANNONOXIDOREDUCT-RXN","metacyc":"MANNONOXIDOREDUCT-RXN","compounds":"D-mannonate + NAD(+) <=> H(+) + keto-D-fructuronate + NADH","pmd":470.074}
{"X":2151,"KEGG":"R02455","RHEA_ID":10635,"DIRECTION":"BI","MASTER_ID":10632,"metacyc":"MANNURONATE-REDUCTASE-RXN","compounds":"D-mannonate + NAD(+) <=> D-mannuronate + H(+) + NADH","pmd":470.074}
{"X":2152,"KEGG":"R02455","RHEA_ID":10635,"DIRECTION":"BI","MASTER_ID":10632,"metacyc":"MANNURONATE-REDUCTASE-RXN","compounds":"D-mannonate + NAD(+) <=> D-mannuronate + H(+) + NADH","pmd":2.016}
{"X":2153,"KEGG":"R02456","RHEA_ID":10639,"DIRECTION":"BI","MASTER_ID":10636,"metacyc":"MANNURONATE-REDUCTASE-RXN","compounds":"D-mannonate + NADP(+) <=> D-mannuronate + H(+) + NADPH","pmd":2.016}
{"X":2154,"KEGG":"R02456","RHEA_ID":10639,"DIRECTION":"BI","MASTER_ID":10636,"metacyc":"MANNURONATE-REDUCTASE-RXN","compounds":"D-mannonate + NADP(+) <=> D-mannuronate + H(+) + NADPH","pmd":550.041}
{"X":2155,"KEGG":"R02458","RHEA_ID":12904,"DIRECTION":"BI","MASTER_ID":12901,"metacyc":"D-ARGINASE-RXN","compounds":"D-arginine + H2O <=> D-ornithine + urea","pmd":42.022}
{"X":2156,"KEGG":"R02461","RHEA_ID":14896,"DIRECTION":"BI","MASTER_ID":14893,"metacyc":"ORNMUTST-RXN","compounds":"D-ornithine <=> (2R,4S)-2,4-diaminopentanoate","pmd":0}
{"X":2157,"KEGG":"R02462","RHEA_ID":22059,"DIRECTION":"BI","MASTER_ID":22056,"compounds":"hexadecan-1-ol + NAD(+) <=> H(+) + hexadecanal + NADH","pmd":2.016}
{"X":2158,"KEGG":"R02462","RHEA_ID":22059,"DIRECTION":"BI","MASTER_ID":22056,"compounds":"hexadecan-1-ol + NAD(+) <=> H(+) + hexadecanal + NADH","pmd":423.872}
{"X":2159,"KEGG":"R02463","RHEA_ID":12447,"DIRECTION":"BI","MASTER_ID":12444,"compounds":"hexadecanal + NADP(+) <=> (2E)-hexadecenal + H(+) + NADPH","pmd":505.854}
{"X":2160,"KEGG":"R02463","RHEA_ID":12447,"DIRECTION":"BI","MASTER_ID":12444,"compounds":"hexadecanal + NADP(+) <=> (2E)-hexadecenal + H(+) + NADPH","pmd":2.016}
{"X":2161,"KEGG":"R02464","RHEA_ID":18596,"DIRECTION":"BI","MASTER_ID":18593,"compounds":"sphinganine 1-phosphate <=> hexadecanal + phosphoethanolamine","pmd":141.019}
{"X":2162,"KEGG":"R02465","RHEA_ID":50243,"DIRECTION":"BI","MASTER_ID":50240,"compounds":"[hyaluronan](n) <=> n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine + H2O"}
{"X":2163,"KEGG":"R02466","RHEA_ID":16880,"DIRECTION":"BI","MASTER_ID":16877,"compounds":"3-sulfino-L-alanine + H(+) <=> CO2 + hypotaurine","pmd":43.99}
{"X":2164,"KEGG":"R02467","RHEA_ID":14412,"DIRECTION":"BI","MASTER_ID":14409,"compounds":"cysteamine + O2 <=> H(+) + hypotaurine"}
{"X":2165,"KEGG":"R02468","RHEA_ID":17948,"DIRECTION":"BI","MASTER_ID":17945,"compounds":"(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] <=> (1S,5R)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":2166,"KEGG":"R02469","RHEA_ID":15132,"DIRECTION":"BI","MASTER_ID":15129,"compounds":"(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] <=> (1S,6R)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":2167,"KEGG":"R02470","RHEA_ID":23435,"DIRECTION":"BI","MASTER_ID":23432,"compounds":"(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] <=> (4S)-perillyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":2168,"KEGG":"R02471","RHEA_ID":23003,"DIRECTION":"BI","MASTER_ID":23000,"compounds":"(R)-pantoate + NAD(+) <=> (R)-4-dehydropantoate + H(+) + NADH","pmd":2.016}
{"X":2169,"KEGG":"R02471","RHEA_ID":23003,"DIRECTION":"BI","MASTER_ID":23000,"compounds":"(R)-pantoate + NAD(+) <=> (R)-4-dehydropantoate + H(+) + NADH","pmd":518.059}
{"X":2170,"KEGG":"R02472","RHEA_ID":16236,"DIRECTION":"BI","MASTER_ID":16233,"compounds":"(R)-pantoate + NADP(+) <=> 2-dehydropantoate + H(+) + NADPH","pmd":2.016}
{"X":2171,"KEGG":"R02472","RHEA_ID":16236,"DIRECTION":"BI","MASTER_ID":16233,"compounds":"(R)-pantoate + NADP(+) <=> 2-dehydropantoate + H(+) + NADPH","pmd":598.025}
{"X":2172,"KEGG":"R02473","RHEA_ID":10915,"DIRECTION":"BI","MASTER_ID":10912,"compounds":"(R)-pantoate + ATP + beta-alanine <=> (R)-pantothenate + AMP + diphosphate + H(+)","pmd":159.933}
{"X":2173,"KEGG":"R02473","RHEA_ID":10915,"DIRECTION":"BI","MASTER_ID":10912,"compounds":"(R)-pantoate + ATP + beta-alanine <=> (R)-pantothenate + AMP + diphosphate + H(+)","pmd":71.037}
{"X":2174,"KEGG":"R02474","RHEA_ID":12451,"DIRECTION":"BI","MASTER_ID":12448,"compounds":"(R)-pantothenate + H2O <=> (R)-pantoate + beta-alanine","pmd":71.037}
{"X":2175,"KEGG":"R02476","RHEA_ID":20384,"DIRECTION":"BI","MASTER_ID":20381,"compounds":"3alpha-hydroxy-5alpha-androstan-17-one + NAD(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADH","pmd":375.908}
{"X":2176,"KEGG":"R02476","RHEA_ID":20384,"DIRECTION":"BI","MASTER_ID":20381,"compounds":"3alpha-hydroxy-5alpha-androstan-17-one + NAD(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADH","pmd":2.016}
{"X":2177,"KEGG":"R02477","RHEA_ID":20380,"DIRECTION":"BI","MASTER_ID":20377,"compounds":"3alpha-hydroxy-5alpha-androstan-17-one + NADP(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADPH","pmd":2.016}
{"X":2178,"KEGG":"R02477","RHEA_ID":20380,"DIRECTION":"BI","MASTER_ID":20377,"compounds":"3alpha-hydroxy-5alpha-androstan-17-one + NADP(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADPH","pmd":455.874}
{"X":2179,"KEGG":"R02480","RHEA_ID":22651,"DIRECTION":"BI","MASTER_ID":22648,"metacyc":"HOLOCYTOCHROME-C-SYNTHASE-RXN","compounds":"holo-[cytochrome c] <=> apo-[cytochrome c] + heme b"}
{"X":2180,"KEGG":"R02481","RHEA_ID":10063,"DIRECTION":"BI","MASTER_ID":10060,"compounds":"acetyl-CoA + D-tryptophan <=> CoA + H(+) + N-acetyl-D-tryptophan","pmd":42.011}
{"X":2181,"KEGG":"R02482","RHEA_ID":23323,"DIRECTION":"BI","MASTER_ID":23320,"compounds":"D-tryptophan + malonyl-CoA <=> CoA + H(+) + N(2)-malonyl-D-tryptophan","pmd":86}
{"X":2182,"KEGG":"R02484","RHEA_ID":22827,"DIRECTION":"BI","MASTER_ID":22824,"ecocyc":"URA-PHOSPH-RXN","metacyc":"URA-PHOSPH-RXN","compounds":"2'-deoxyuridine + phosphate <=> 2-deoxy-alpha-D-ribose 1-phosphate + uracil","pmd":14.05}
{"X":2183,"KEGG":"R02485","RHEA_ID":13436,"DIRECTION":"BI","MASTER_ID":13433,"compounds":"2'-deoxycytidine + H(+) + H2O <=> 2'-deoxyuridine + NH4(+)","pmd":0.984}
{"X":2184,"KEGG":"R02486","RHEA_ID":23319,"DIRECTION":"BI","MASTER_ID":23316,"compounds":"2'-deoxyuridine + 2-oxoglutarate + O2 <=> 2-deoxy-D-ribono-1,4-lactone + CO2 + succinate + uracil","pmd":96.032}
{"X":2185,"KEGG":"R02486","RHEA_ID":23319,"DIRECTION":"BI","MASTER_ID":23316,"compounds":"2'-deoxyuridine + 2-oxoglutarate + O2 <=> 2-deoxy-D-ribono-1,4-lactone + CO2 + succinate + uracil","pmd":13.979}
{"X":2186,"KEGG":"R02487","RHEA_ID":30850,"DIRECTION":"BI","MASTER_ID":30847,"compounds":"FAD + glutaryl-CoA + 2 H(+) <=> (2E)-butenoyl-CoA + CO2 + FADH2","pmd":2.016}
{"X":2187,"KEGG":"R02487","RHEA_ID":30850,"DIRECTION":"BI","MASTER_ID":30847,"compounds":"FAD + glutaryl-CoA + 2 H(+) <=> (2E)-butenoyl-CoA + CO2 + FADH2","pmd":46.005}
{"X":2188,"KEGG":"R02488","RHEA_ID":13392,"DIRECTION":"BI","MASTER_ID":13389,"metacyc":"GLUTARYL-COA-DEHYDROGENASE-RXN","compounds":"glutaryl-CoA + 2 H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-butenoyl-CoA + CO2 + reduced [electron-transfer flavoprotein]","pmd":46.005}
{"X":2189,"KEGG":"R02489","RHEA_ID":21315,"DIRECTION":"BI","MASTER_ID":21312,"compounds":"2,5-dihydroxybenzoate + H(+) <=> CO2 + hydroquinone","pmd":43.99}
{"X":2190,"KEGG":"R02490","RHEA_ID":13788,"DIRECTION":"BI","MASTER_ID":13785,"compounds":"citramalyl-CoA <=> H2O + itaconyl-CoA","pmd":18.01}
{"X":2191,"KEGG":"R02492","RHEA_ID":29610,"DIRECTION":"BI","MASTER_ID":29607,"metacyc":"RXN-12112","compounds":"H2O + NAD(+) + nitrous oxide <=> H(+) + NADH + 2 nitric oxide"}
{"X":2192,"KEGG":"R02493","RHEA_ID":25107,"DIRECTION":"BI","MASTER_ID":25104,"compounds":"ATP + pyridoxamine <=> ADP + H(+) + pyridoxamine 5'-phosphate","pmd":79.966}
{"X":2193,"KEGG":"R02494","RHEA_ID":25138,"DIRECTION":"BI","MASTER_ID":25135,"compounds":"phosphate + pyridoxamine <=> H2O + pyridoxamine 5'-phosphate","pmd":79.966}
{"X":2194,"KEGG":"R02497","RHEA_ID":50823,"DIRECTION":"BI","MASTER_ID":50820,"compounds":"17beta-hydroxy-5alpha-androstan-3-one + NADP(+) <=> H(+) + NADPH + testosterone","pmd":2.016}
{"X":2195,"KEGG":"R02497","RHEA_ID":50823,"DIRECTION":"BI","MASTER_ID":50820,"compounds":"17beta-hydroxy-5alpha-androstan-3-one + NADP(+) <=> H(+) + NADPH + testosterone","pmd":455.874}
{"X":2196,"KEGG":"R02498","RHEA_ID":46639,"DIRECTION":"BI","MASTER_ID":46636,"compounds":"5beta-dihydrotestosterone + NADP(+) <=> H(+) + NADPH + testosterone","pmd":2.016}
{"X":2197,"KEGG":"R02498","RHEA_ID":46639,"DIRECTION":"BI","MASTER_ID":46636,"compounds":"5beta-dihydrotestosterone + NADP(+) <=> H(+) + NADPH + testosterone","pmd":455.874}
{"X":2198,"KEGG":"R02501","RHEA_ID":38182,"DIRECTION":"BI","MASTER_ID":38179,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 19-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":2199,"KEGG":"R02504","RHEA_ID":11091,"DIRECTION":"BI","MASTER_ID":11088,"compounds":"H2O + trimetaphosphate <=> 2 H(+) + triphosphate"}
{"X":2200,"KEGG":"R02505","RHEA_ID":12555,"DIRECTION":"BI","MASTER_ID":12552,"compounds":"(E)-cinnamoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> (E)-pinosylvin + 4 CO2 + 4 CoA","pmd":130.042}
{"X":2201,"KEGG":"R02505","RHEA_ID":12555,"DIRECTION":"BI","MASTER_ID":12552,"compounds":"(E)-cinnamoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> (E)-pinosylvin + 4 CO2 + 4 CoA","pmd":86}
{"X":2202,"KEGG":"R02506","RHEA_ID":10623,"DIRECTION":"BI","MASTER_ID":10620,"metacyc":"CINNAMOYL-COA-REDUCTASE-RXN","compounds":"(E)-cinnamaldehyde + CoA + NADP(+) <=> (E)-cinnamoyl-CoA + H(+) + NADPH","pmd":22.024}
{"X":2203,"KEGG":"R02506","RHEA_ID":10623,"DIRECTION":"BI","MASTER_ID":10620,"metacyc":"CINNAMOYL-COA-REDUCTASE-RXN","compounds":"(E)-cinnamaldehyde + CoA + NADP(+) <=> (E)-cinnamoyl-CoA + H(+) + NADPH","pmd":613.034}
{"X":2204,"KEGG":"R02506","RHEA_ID":10623,"DIRECTION":"BI","MASTER_ID":10620,"metacyc":"CINNAMOYL-COA-REDUCTASE-RXN","compounds":"(E)-cinnamaldehyde + CoA + NADP(+) <=> (E)-cinnamoyl-CoA + H(+) + NADPH","pmd":153.074}
{"X":2205,"KEGG":"R02509","RHEA_ID":19520,"DIRECTION":"BI","MASTER_ID":19517,"metacyc":"NN-DIMETHYLFORMAMIDASE-RXN","compounds":"H2O + N,N-dimethylformamide <=> dimethylamine + formate"}
{"X":2206,"KEGG":"R02511","RHEA_ID":11867,"DIRECTION":"BI","MASTER_ID":11864,"ecocyc":"1.5.8.2-RXN","metacyc":"1.5.8.2-RXN","compounds":"H(+) + H2O + oxidized [electron-transfer flavoprotein] + trimethylamine <=> dimethylamine + formaldehyde + reduced [electron-transfer flavoprotein]"}
{"X":2207,"KEGG":"R02512","RHEA_ID":20220,"DIRECTION":"BI","MASTER_ID":20217,"compounds":"H(+) + trimethylamine N-oxide <=> dimethylamine + formaldehyde"}
{"X":2208,"KEGG":"R02513","RHEA_ID":17308,"DIRECTION":"BI","MASTER_ID":17305,"metacyc":"DIMETHYLARGININASE-RXN","compounds":"H2O + N(omega),N(omega)-dimethyl-L-arginine <=> dimethylamine + L-citrulline","pmd":27.047}
{"X":2209,"KEGG":"R02514","RHEA_ID":15164,"DIRECTION":"BI","MASTER_ID":15161,"compounds":"4-hydroxyphenylacetate + H(+) + NADH + O2 <=> H2O + homogentisate + NAD(+)","pmd":497.083}
{"X":2210,"KEGG":"R02514","RHEA_ID":15164,"DIRECTION":"BI","MASTER_ID":15161,"compounds":"4-hydroxyphenylacetate + H(+) + NADH + O2 <=> H2O + homogentisate + NAD(+)","pmd":15.995}
{"X":2211,"KEGG":"R02515","RHEA_ID":22211,"DIRECTION":"BI","MASTER_ID":22208,"compounds":"3-hydroxyphenylacetate + H(+) + NADH + O2 <=> H2O + homogentisate + NAD(+)","pmd":15.995}
{"X":2212,"KEGG":"R02515","RHEA_ID":22211,"DIRECTION":"BI","MASTER_ID":22208,"compounds":"3-hydroxyphenylacetate + H(+) + NADH + O2 <=> H2O + homogentisate + NAD(+)","pmd":497.083}
{"X":2213,"KEGG":"R02516","RHEA_ID":15160,"DIRECTION":"BI","MASTER_ID":15157,"compounds":"4-hydroxyphenylacetate + H(+) + NADPH + O2 <=> H2O + homogentisate + NADP(+)","pmd":15.995}
{"X":2214,"KEGG":"R02516","RHEA_ID":15160,"DIRECTION":"BI","MASTER_ID":15157,"compounds":"4-hydroxyphenylacetate + H(+) + NADPH + O2 <=> H2O + homogentisate + NADP(+)","pmd":577.049}
{"X":2215,"KEGG":"R02517","RHEA_ID":22207,"DIRECTION":"BI","MASTER_ID":22204,"compounds":"3-hydroxyphenylacetate + H(+) + NADPH + O2 <=> H2O + homogentisate + NADP(+)","pmd":15.995}
{"X":2216,"KEGG":"R02517","RHEA_ID":22207,"DIRECTION":"BI","MASTER_ID":22204,"compounds":"3-hydroxyphenylacetate + H(+) + NADPH + O2 <=> H2O + homogentisate + NADP(+)","pmd":577.049}
{"X":2217,"KEGG":"R02519","RHEA_ID":15452,"DIRECTION":"BI","MASTER_ID":15449,"compounds":"homogentisate + O2 <=> 4-maleylacetoacetate + H(+)","pmd":31.99}
{"X":2218,"KEGG":"R02521","RHEA_ID":16192,"DIRECTION":"BI","MASTER_ID":16189,"compounds":"3-(4-hydroxyphenyl)pyruvate + O2 <=> CO2 + homogentisate","pmd":12}
{"X":2219,"KEGG":"R02522","RHEA_ID":20971,"DIRECTION":"BI","MASTER_ID":20968,"compounds":"L-arabinonate <=> 2-dehydro-3-deoxy-L-arabinonate + H2O","pmd":18.01}
{"X":2220,"KEGG":"R02526","RHEA_ID":16220,"DIRECTION":"BI","MASTER_ID":16217,"compounds":"H2O + L-arabinono-1,4-lactone <=> H(+) + L-arabinonate","pmd":18.01}
{"X":2221,"KEGG":"R02527","RHEA_ID":24531,"DIRECTION":"BI","MASTER_ID":24528,"metacyc":"D-LACTALDEHYDE-DEHYDROGENASE-RXN","compounds":"(R)-lactaldehyde + NAD(+) <=> H(+) + methylglyoxal + NADH"}
{"X":2222,"KEGG":"R02528","RHEA_ID":27989,"DIRECTION":"BI","MASTER_ID":27986,"compounds":"hydroxyacetone + NADP(+) <=> H(+) + methylglyoxal + NADPH"}
{"X":2223,"KEGG":"R02529","RHEA_ID":28189,"DIRECTION":"BI","MASTER_ID":28186,"compounds":"aminoacetone + H2O + O2 <=> H2O2 + methylglyoxal + NH4(+)"}
{"X":2224,"KEGG":"R02530","RHEA_ID":19072,"DIRECTION":"BI","MASTER_ID":19069,"metacyc":"GLYOXI-RXN","compounds":"(R)-S-lactoylglutathione <=> glutathione + methylglyoxal","pmd":72.021}
{"X":2225,"KEGG":"R02533","RHEA_ID":25272,"DIRECTION":"BI","MASTER_ID":25269,"compounds":"(R)-noradrenaline + S-adenosyl-L-methionine <=> (R)-adrenaline + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":2226,"KEGG":"R02535","RHEA_ID":19120,"DIRECTION":"BI","MASTER_ID":19117,"compounds":"dopamine + 2 L-ascorbate + O2 <=> (R)-noradrenaline + H2O + 2 monodehydro-L-ascorbate radical","pmd":6.958}
{"X":2227,"KEGG":"R02535","RHEA_ID":19120,"DIRECTION":"BI","MASTER_ID":19117,"compounds":"dopamine + 2 L-ascorbate + O2 <=> (R)-noradrenaline + H2O + 2 monodehydro-L-ascorbate radical","pmd":15.995}
{"X":2228,"KEGG":"R02536","RHEA_ID":21395,"DIRECTION":"BI","MASTER_ID":21392,"ecocyc":"PHENDEHYD-RXN","metacyc":"PHENDEHYD-RXN","compounds":"2-phenylacetaldehyde + H2O + NAD(+) <=> 2-phenylacetate + 2 H(+) + NADH","pmd":528.064}
{"X":2229,"KEGG":"R02536","RHEA_ID":21395,"DIRECTION":"BI","MASTER_ID":21392,"ecocyc":"PHENDEHYD-RXN","metacyc":"PHENDEHYD-RXN","compounds":"2-phenylacetaldehyde + H2O + NAD(+) <=> 2-phenylacetate + 2 H(+) + NADH","pmd":15.995}
{"X":2230,"KEGG":"R02539","RHEA_ID":20959,"DIRECTION":"BI","MASTER_ID":20956,"metacyc":"PHENYLACETATE--COA-LIGASE-RXN","compounds":"2-phenylacetate + ATP + CoA <=> AMP + diphosphate + phenylacetyl-CoA","pmd":159.933}
{"X":2231,"KEGG":"R02539","RHEA_ID":20959,"DIRECTION":"BI","MASTER_ID":20956,"metacyc":"PHENYLACETATE--COA-LIGASE-RXN","compounds":"2-phenylacetate + ATP + CoA <=> AMP + diphosphate + phenylacetyl-CoA","pmd":118.042}
{"X":2232,"KEGG":"R02539","RHEA_ID":20959,"DIRECTION":"BI","MASTER_ID":20956,"metacyc":"PHENYLACETATE--COA-LIGASE-RXN","compounds":"2-phenylacetate + ATP + CoA <=> AMP + diphosphate + phenylacetyl-CoA","pmd":211.011}
{"X":2233,"KEGG":"R02541","RHEA_ID":19256,"DIRECTION":"BI","MASTER_ID":19253,"compounds":"H2O + sphingomyelin <=> an N-acylsphing-4-enine + H(+) + phosphocholine"}
{"X":2234,"KEGG":"R02541","RHEA_ID":34742,"DIRECTION":"BI","MASTER_ID":34739,"compounds":"H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine <=> H(+) + N-acyl-15-methylhexadecasphing-4-enine + phosphocholine"}
{"X":2235,"KEGG":"R02542","RHEA_ID":20987,"DIRECTION":"BI","MASTER_ID":20984,"metacyc":"SPHINGOMYELIN-PHOSPHODIESTERASE-D-RXN","compounds":"H2O + sphingomyelin <=> choline + H(+) + N-acylsphing-4-enine 1-phosphate"}
{"X":2236,"KEGG":"R02544","RHEA_ID":18556,"DIRECTION":"BI","MASTER_ID":18553,"compounds":"(2R,3S)-tartrate + NAD(+) <=> dihydroxyfumarate + H(+) + NADH","pmd":516.116}
{"X":2237,"KEGG":"R02544","RHEA_ID":18556,"DIRECTION":"BI","MASTER_ID":18553,"compounds":"(2R,3S)-tartrate + NAD(+) <=> dihydroxyfumarate + H(+) + NADH","pmd":2.016}
{"X":2238,"KEGG":"R02545","RHEA_ID":16460,"DIRECTION":"BI","MASTER_ID":16457,"metacyc":"RXN-8643","compounds":"(2R,3S)-tartrate + NAD(+) <=> 2-hydroxy-3-oxosuccinate + H(+) + NADH","pmd":516.116}
{"X":2239,"KEGG":"R02545","RHEA_ID":16460,"DIRECTION":"BI","MASTER_ID":16457,"metacyc":"RXN-8643","compounds":"(2R,3S)-tartrate + NAD(+) <=> 2-hydroxy-3-oxosuccinate + H(+) + NADH","pmd":2.016}
{"X":2240,"KEGG":"R02546","RHEA_ID":22215,"DIRECTION":"BI","MASTER_ID":22212,"compounds":"(2R,3R)-tartrate <=> (2R,3S)-tartrate","pmd":0}
{"X":2241,"KEGG":"R02547","RHEA_ID":20743,"DIRECTION":"BI","MASTER_ID":20740,"compounds":"H2O + trans-2,3-epoxysuccinate <=> (2R,3S)-tartrate","pmd":18.011}
{"X":2242,"KEGG":"R02548","RHEA_ID":23815,"DIRECTION":"BI","MASTER_ID":23812,"compounds":"(+)-neomenthol + NADP(+) <=> (1R,4S)-menthone + H(+) + NADPH","pmd":589.947}
{"X":2243,"KEGG":"R02548","RHEA_ID":23815,"DIRECTION":"BI","MASTER_ID":23812,"compounds":"(+)-neomenthol + NADP(+) <=> (1R,4S)-menthone + H(+) + NADPH","pmd":2.016}
{"X":2244,"KEGG":"R02549","RHEA_ID":19108,"DIRECTION":"BI","MASTER_ID":19105,"compounds":"4-aminobutanal + H2O + NAD(+) <=> 4-aminobutanoate + 2 H(+) + NADH","pmd":561.054}
{"X":2245,"KEGG":"R02550","RHEA_ID":51595,"DIRECTION":"BI","MASTER_ID":51592,"compounds":"2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + toluene <=> benzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":2246,"KEGG":"R02551","RHEA_ID":20903,"DIRECTION":"BI","MASTER_ID":20900,"compounds":"H(+) + H2O + N-benzyloxycarbonylglycine <=> benzyl alcohol + CO2 + glycine","pmd":101.011}
{"X":2247,"KEGG":"R02553","RHEA_ID":11731,"DIRECTION":"BI","MASTER_ID":11728,"metacyc":"CYCLOPENTANOL-DEHYDROGENASE-RXN","compounds":"cyclopentanol + NAD(+) <=> cyclopentanone + H(+) + NADH"}
{"X":2248,"KEGG":"R02554","RHEA_ID":15740,"DIRECTION":"BI","MASTER_ID":15737,"compounds":"cyclopentanone + H(+) + NADPH + O2 <=> 5-valerolactone + H2O + NADP(+)","pmd":645.039}
{"X":2249,"KEGG":"R02555","RHEA_ID":17816,"DIRECTION":"BI","MASTER_ID":17813,"ecocyc":"ALTRO-OXIDOREDUCT-RXN","metacyc":"ALTRO-OXIDOREDUCT-RXN","compounds":"D-altronate + NAD(+) <=> H(+) + keto-D-tagaturonate + NADH","pmd":2.016}
{"X":2250,"KEGG":"R02555","RHEA_ID":17816,"DIRECTION":"BI","MASTER_ID":17813,"ecocyc":"ALTRO-OXIDOREDUCT-RXN","metacyc":"ALTRO-OXIDOREDUCT-RXN","compounds":"D-altronate + NAD(+) <=> H(+) + keto-D-tagaturonate + NADH","pmd":470.074}
{"X":2251,"KEGG":"R02556","RHEA_ID":28193,"DIRECTION":"BI","MASTER_ID":28190,"ecocyc":"ADDALT-RXN","metacyc":"ADDALT-RXN","compounds":"2'-deoxyadenosine + H(+) + H2O <=> 2'-deoxyinosine + NH4(+)","pmd":0.984}
{"X":2252,"KEGG":"R02557","RHEA_ID":27745,"DIRECTION":"BI","MASTER_ID":27742,"ecocyc":"DEOXYADENPHOSPHOR-RXN","metacyc":"DEOXYADENPHOSPHOR-RXN","compounds":"2'-deoxyadenosine + phosphate <=> 2-deoxy-alpha-D-ribose 1-phosphate + adenine","pmd":37.078}
{"X":2253,"KEGG":"R02558","RHEA_ID":16492,"DIRECTION":"BI","MASTER_ID":16489,"compounds":"(R)-prunasin + H2O <=> D-glucose + mandelonitrile","pmd":115.042}
{"X":2254,"KEGG":"R02559","RHEA_ID":22027,"DIRECTION":"BI","MASTER_ID":22024,"compounds":"H2O + NAD(+) + trimethylamine <=> 2 H(+) + NADH + trimethylamine N-oxide"}
{"X":2255,"KEGG":"R02561","RHEA_ID":11055,"DIRECTION":"BI","MASTER_ID":11052,"compounds":"4-aminobenzoate + 2 H(+) + NADH + O2 <=> 4-aminophenol + CO2 + H2O + NAD(+)","pmd":556.072}
{"X":2256,"KEGG":"R02561","RHEA_ID":11055,"DIRECTION":"BI","MASTER_ID":11052,"compounds":"4-aminobenzoate + 2 H(+) + NADH + O2 <=> 4-aminophenol + CO2 + H2O + NAD(+)","pmd":27.995}
{"X":2257,"KEGG":"R02562","RHEA_ID":11059,"DIRECTION":"BI","MASTER_ID":11056,"compounds":"4-aminobenzoate + 2 H(+) + NADPH + O2 <=> 4-aminophenol + CO2 + H2O + NADP(+)","pmd":27.995}
{"X":2258,"KEGG":"R02562","RHEA_ID":11059,"DIRECTION":"BI","MASTER_ID":11056,"compounds":"4-aminobenzoate + 2 H(+) + NADPH + O2 <=> 4-aminophenol + CO2 + H2O + NADP(+)","pmd":636.038}
{"X":2259,"KEGG":"R02563","RHEA_ID":22659,"DIRECTION":"BI","MASTER_ID":22656,"compounds":"CDP-ethanolamine + L-serine <=> CMP + H(+) + L-serine-phosphoethanolamine","pmd":123.008}
{"X":2260,"KEGG":"R02563","RHEA_ID":22659,"DIRECTION":"BI","MASTER_ID":22656,"compounds":"CDP-ethanolamine + L-serine <=> CMP + H(+) + L-serine-phosphoethanolamine","pmd":123.009}
{"X":2261,"KEGG":"R02564","RHEA_ID":18484,"DIRECTION":"BI","MASTER_ID":18481,"compounds":"cyclohexylsulfamate + H2O <=> cyclohexylamine + sulfate"}
{"X":2262,"KEGG":"R02565","RHEA_ID":15308,"DIRECTION":"BI","MASTER_ID":15305,"metacyc":"BADH-RXN","compounds":"betaine aldehyde + H2O + NAD(+) <=> betaine + 2 H(+) + NADH","pmd":547.038}
{"X":2263,"KEGG":"R02565","RHEA_ID":15308,"DIRECTION":"BI","MASTER_ID":15305,"metacyc":"BADH-RXN","compounds":"betaine aldehyde + H2O + NAD(+) <=> betaine + 2 H(+) + NADH","pmd":14.987}
{"X":2264,"KEGG":"R02566","RHEA_ID":30070,"DIRECTION":"BI","MASTER_ID":30067,"compounds":"betaine aldehyde + H2O + NADP(+) <=> betaine + 2 H(+) + NADPH","pmd":14.987}
{"X":2265,"KEGG":"R02566","RHEA_ID":30070,"DIRECTION":"BI","MASTER_ID":30067,"compounds":"betaine aldehyde + H2O + NADP(+) <=> betaine + 2 H(+) + NADPH","pmd":627.004}
{"X":2266,"KEGG":"R02568","RHEA_ID":30854,"DIRECTION":"BI","MASTER_ID":30851,"compounds":"beta-D-fructose 1-phosphate <=> D-glyceraldehyde + dihydroxyacetone phosphate","pmd":90.032}
{"X":2267,"KEGG":"R02569","RHEA_ID":17020,"DIRECTION":"BI","MASTER_ID":17017,"metacyc":"RXN0-1133","compounds":"(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA <=> (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA","pmd":42.011}
{"X":2268,"KEGG":"R02570","RHEA_ID":15216,"DIRECTION":"BI","MASTER_ID":15213,"compounds":"(R)-N(6)-dihydrolipoyl-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA <=> (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoA","pmd":100.016}
{"X":2269,"KEGG":"R02572","RHEA_ID":19616,"DIRECTION":"BI","MASTER_ID":19613,"compounds":"dimethyl sulfide + S-adenosyl-L-methionine <=> S-adenosyl-L-homocysteine + trimethylsulfonium","pmd":14.016}
{"X":2270,"KEGG":"R02573","RHEA_ID":13696,"DIRECTION":"BI","MASTER_ID":13693,"compounds":"(6S)-5,6,7,8-tetrahydrofolate + trimethylsulfonium <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + dimethyl sulfide + H(+)","pmd":14.016}
{"X":2271,"KEGG":"R02574","RHEA_ID":19968,"DIRECTION":"BI","MASTER_ID":19965,"compounds":"S,S-dimethyl-beta-propiothetin <=> acrylate + dimethyl sulfide + H(+)"}
{"X":2272,"KEGG":"R02575","RHEA_ID":14148,"DIRECTION":"BI","MASTER_ID":14145,"metacyc":"GUANIDOACETATE-KINASE-RXN","compounds":"ATP + guanidinoacetate <=> ADP + H(+) + phosphoguanidinoacetate","pmd":79.966}
{"X":2273,"KEGG":"R02576","RHEA_ID":21847,"DIRECTION":"BI","MASTER_ID":21844,"metacyc":"GLUTAMINE-N-PHENYLACETYLTRANSFERASE-RXN","compounds":"L-glutamine + phenylacetyl-CoA <=> CoA + H(+) + N(2)-phenylacetyl-L-glutamine","pmd":118.042}
{"X":2274,"KEGG":"R02580","RHEA_ID":11879,"DIRECTION":"BI","MASTER_ID":11876,"metacyc":"1.1.1.141-RXN","compounds":"NAD(+) + prostaglandin E2 <=> 15-oxo-prostaglandin E2 + H(+) + NADH","pmd":313.908}
{"X":2275,"KEGG":"R02580","RHEA_ID":11879,"DIRECTION":"BI","MASTER_ID":11876,"metacyc":"1.1.1.141-RXN","compounds":"NAD(+) + prostaglandin E2 <=> 15-oxo-prostaglandin E2 + H(+) + NADH","pmd":2.016}
{"X":2276,"KEGG":"R02581","RHEA_ID":24511,"DIRECTION":"BI","MASTER_ID":24508,"metacyc":"PROSTAGLANDIN-E2-9-REDUCTASE-RXN","compounds":"NADP(+) + prostaglandin F2alpha <=> H(+) + NADPH + prostaglandin E2","pmd":391.858}
{"X":2277,"KEGG":"R02581","RHEA_ID":24511,"DIRECTION":"BI","MASTER_ID":24508,"metacyc":"PROSTAGLANDIN-E2-9-REDUCTASE-RXN","compounds":"NADP(+) + prostaglandin F2alpha <=> H(+) + NADPH + prostaglandin E2","pmd":2.016}
{"X":2278,"KEGG":"R02584","RHEA_ID":10599,"DIRECTION":"BI","MASTER_ID":10596,"compounds":"ATP + L-tyrosyl-[protein] <=> ADP + H(+) + O-phospho-L-tyrosyl-[protein]","pmd":79.966}
{"X":2279,"KEGG":"R02585","RHEA_ID":10687,"DIRECTION":"BI","MASTER_ID":10684,"compounds":"H2O + O-phospho-L-tyrosyl-[protein] <=> L-tyrosyl-[protein] + phosphate"}
{"X":2280,"KEGG":"R02586","RHEA_ID":16804,"DIRECTION":"BI","MASTER_ID":16801,"metacyc":"PROTEIN-TYROSINE-SULFOTRANSFERASE-RXN","compounds":"3'-phosphoadenylyl sulfate + L-tyrosyl-[protein] <=> adenosine 3',5'-bisphosphate + H(+) + O-sulfo-L-tyrosine-[protein]","pmd":79.957}
{"X":2281,"KEGG":"R02587","RHEA_ID":22239,"DIRECTION":"BI","MASTER_ID":22236,"compounds":"2-deoxy-D-glucose 6-phosphate + H2O <=> 2-deoxy-D-glucose + phosphate","pmd":79.966}
{"X":2282,"KEGG":"R02588","RHEA_ID":15320,"DIRECTION":"BI","MASTER_ID":15317,"compounds":"a 2-deoxy-alpha-D-glucoside + H2O <=> 2-deoxy-D-glucose + an alcohol"}
{"X":2283,"KEGG":"R02589","RHEA_ID":22695,"DIRECTION":"BI","MASTER_ID":22692,"compounds":"3-hydroxybenzoate + H(+) + NADH + O2 <=> 2,5-dihydroxybenzoate + H2O + NAD(+)","pmd":15.995}
{"X":2284,"KEGG":"R02589","RHEA_ID":22695,"DIRECTION":"BI","MASTER_ID":22692,"compounds":"3-hydroxybenzoate + H(+) + NADH + O2 <=> 2,5-dihydroxybenzoate + H2O + NAD(+)","pmd":511.098}
{"X":2285,"KEGG":"R02591","RHEA_ID":19548,"DIRECTION":"BI","MASTER_ID":19545,"compounds":"H2O + sn-glycerol 3-phosphocholine <=> glycerol + H(+) + phosphocholine","pmd":74.037}
{"X":2286,"KEGG":"R02593","RHEA_ID":22447,"DIRECTION":"BI","MASTER_ID":22444,"compounds":"(E)-coniferol + NADP(+) <=> (E)-coniferaldehyde + H(+) + NADPH","pmd":2.016}
{"X":2287,"KEGG":"R02593","RHEA_ID":22447,"DIRECTION":"BI","MASTER_ID":22444,"compounds":"(E)-coniferol + NADP(+) <=> (E)-coniferaldehyde + H(+) + NADPH","pmd":566.02}
{"X":2288,"KEGG":"R02594","RHEA_ID":23947,"DIRECTION":"BI","MASTER_ID":23944,"compounds":"(E)-coniferol + UDP-alpha-D-glucose <=> 4-O-(beta-D-glucosyl)-trans-coniferol + H(+) + UDP","pmd":162.053}
{"X":2289,"KEGG":"R02595","RHEA_ID":12255,"DIRECTION":"BI","MASTER_ID":12252,"compounds":"4-O-(beta-D-glucosyl)-trans-coniferol + H2O <=> (E)-coniferol + D-glucose","pmd":162.053}
{"X":2290,"KEGG":"R02597","RHEA_ID":13060,"DIRECTION":"BI","MASTER_ID":13057,"compounds":"an N-acylneuraminate 9-phosphate + H2O <=> an N-acylneuraminate + phosphate"}
{"X":2291,"KEGG":"R02598","RHEA_ID":20188,"DIRECTION":"BI","MASTER_ID":20185,"compounds":"a CMP-N-acyl-beta-neuraminate + H2O <=> an N-acylneuraminate + CMP + H(+)"}
{"X":2292,"KEGG":"R02599","RHEA_ID":11347,"DIRECTION":"BI","MASTER_ID":11344,"metacyc":"ACYLNEURAMINATE-CYTIDYLYLTRANSFERASE-RXN","compounds":"an N-acylneuraminate + CTP <=> a CMP-N-acyl-beta-neuraminate + diphosphate"}
{"X":2293,"KEGG":"R02600","RHEA_ID":29594,"DIRECTION":"BI","MASTER_ID":29591,"compounds":"2-hydroxyethane-1-sulfonate + NADP(+) <=> H(+) + NADPH + sulfoacetaldehyde","pmd":2.016}
{"X":2294,"KEGG":"R02600","RHEA_ID":29594,"DIRECTION":"BI","MASTER_ID":29591,"compounds":"2-hydroxyethane-1-sulfonate + NADP(+) <=> H(+) + NADPH + sulfoacetaldehyde","pmd":619.092}
{"X":2295,"KEGG":"R02601","RHEA_ID":22583,"DIRECTION":"BI","MASTER_ID":22580,"metacyc":"2-OXOPENT-4-ENOATE-HYDRATASE-RXN","compounds":"(S)-4-hydroxy-2-oxopentanoate <=> (2Z)-2-hydroxypenta-2,4-dienoate + H2O","pmd":18.011}
{"X":2296,"KEGG":"R02602","RHEA_ID":24263,"DIRECTION":"BI","MASTER_ID":24260,"compounds":"(3E)-2-oxohex-3-enedioate + H(+) <=> 2-oxopent-4-enoate + CO2","pmd":43.99}
{"X":2297,"KEGG":"R02603","RHEA_ID":34190,"DIRECTION":"BI","MASTER_ID":34187,"compounds":"(2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O <=> (2Z)-2-hydroxypenta-2,4-dienoate + H(+) + succinate","pmd":96.021}
{"X":2298,"KEGG":"R02603","RHEA_ID":34190,"DIRECTION":"BI","MASTER_ID":34187,"compounds":"(2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O <=> (2Z)-2-hydroxypenta-2,4-dienoate + H(+) + succinate","pmd":100.016}
{"X":2299,"KEGG":"R02603","RHEA_ID":24792,"DIRECTION":"BI","MASTER_ID":24789,"ecocyc":"MHPCHYDROL-RXN","metacyc":"MHPCHYDROL-RXN","compounds":"(2E,4Z)-2-hydroxy-6-oxononadienedioate + H2O <=> (2E)-2-hydroxypenta-2,4-dienoate + H(+) + succinate","pmd":96.021}
{"X":2300,"KEGG":"R02603","RHEA_ID":24792,"DIRECTION":"BI","MASTER_ID":24789,"ecocyc":"MHPCHYDROL-RXN","metacyc":"MHPCHYDROL-RXN","compounds":"(2E,4Z)-2-hydroxy-6-oxononadienedioate + H2O <=> (2E)-2-hydroxypenta-2,4-dienoate + H(+) + succinate","pmd":100.016}
{"X":2301,"KEGG":"R02604","RHEA_ID":14552,"DIRECTION":"BI","MASTER_ID":14549,"compounds":"(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O <=> 2-oxopent-4-enoate + formate + H(+)","pmd":27.995}
{"X":2302,"KEGG":"R02605","RHEA_ID":11623,"DIRECTION":"BI","MASTER_ID":11620,"compounds":"H2O + L-2-amino-4-chloropent-4-enoate <=> 2-oxopent-4-enoate + chloride + H(+) + NH4(+)","pmd":34.993}
{"X":2303,"KEGG":"R02606","RHEA_ID":17164,"DIRECTION":"BI","MASTER_ID":17161,"compounds":"2,6-dioxo-6-phenylhexa-3-enoate + H2O <=> 2-oxopent-4-enoate + benzoate + H(+)","pmd":96.021}
{"X":2304,"KEGG":"R02609","RHEA_ID":11527,"DIRECTION":"BI","MASTER_ID":11524,"metacyc":"CHOLESTENONE-5-BETA-REDUCTASE-RXN","compounds":"5beta-cholestan-3-one + NADP(+) <=> cholest-4-en-3-one + H(+) + NADPH","pmd":2.016}
{"X":2305,"KEGG":"R02609","RHEA_ID":11527,"DIRECTION":"BI","MASTER_ID":11524,"metacyc":"CHOLESTENONE-5-BETA-REDUCTASE-RXN","compounds":"5beta-cholestan-3-one + NADP(+) <=> cholest-4-en-3-one + H(+) + NADPH","pmd":359.744}
{"X":2306,"KEGG":"R02610","RHEA_ID":24555,"DIRECTION":"BI","MASTER_ID":24552,"compounds":"5alpha-cholestan-3-one + NADP(+) <=> cholest-4-en-3-one + H(+) + NADPH","pmd":359.744}
{"X":2307,"KEGG":"R02610","RHEA_ID":24555,"DIRECTION":"BI","MASTER_ID":24552,"compounds":"5alpha-cholestan-3-one + NADP(+) <=> cholest-4-en-3-one + H(+) + NADPH","pmd":2.016}
{"X":2308,"KEGG":"R02612","RHEA_ID":36726,"DIRECTION":"BI","MASTER_ID":36723,"compounds":"2-phenylethylamine + A + H2O <=> 2-phenylacetaldehyde + AH2 + NH4(+)","pmd":1.032}
{"X":2309,"KEGG":"R02613","RHEA_ID":25268,"DIRECTION":"BI","MASTER_ID":25265,"compounds":"2-phenylethylamine + H2O + O2 <=> 2-phenylacetaldehyde + H2O2 + NH4(+)","pmd":1.032}
{"X":2310,"KEGG":"R02615","RHEA_ID":21607,"DIRECTION":"BI","MASTER_ID":21604,"metacyc":"STYRENE-OXIDE-ISOMERASE-RXN","compounds":"styrene oxide <=> 2-phenylacetaldehyde","pmd":0}
{"X":2311,"KEGG":"R02616","RHEA_ID":15716,"DIRECTION":"BI","MASTER_ID":15713,"ecocyc":"GALACTOACETYLTRAN-RXN","metacyc":"GALACTOACETYLTRAN-RXN","compounds":"a beta-D-galactoside + acetyl-CoA <=> a 6-acetyl-beta-D-galactoside + CoA","pmd":42.011}
{"X":2312,"KEGG":"R02620","RHEA_ID":15440,"DIRECTION":"BI","MASTER_ID":15437,"metacyc":"LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN","compounds":"a long-chain fatty aldehyde + CoA + NADP(+) <=> a long-chain fatty acyl-CoA + H(+) + NADPH","pmd":22.024}
{"X":2313,"KEGG":"R02621","RHEA_ID":18092,"DIRECTION":"BI","MASTER_ID":18089,"compounds":"H2O + L-arginyl-[protein] <=> L-citrullyl-[protein] + NH4(+)"}
{"X":2314,"KEGG":"R02622","RHEA_ID":16444,"DIRECTION":"BI","MASTER_ID":16441,"compounds":"H2O + L-glutaminyl-[protein] <=> L-glutamyl-[protein] + NH4(+)"}
{"X":2315,"KEGG":"R02623","RHEA_ID":24455,"DIRECTION":"BI","MASTER_ID":24452,"compounds":"L-glutamyl-[protein] + S-adenosyl-L-methionine <=> [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":2316,"KEGG":"R02624","RHEA_ID":23239,"DIRECTION":"BI","MASTER_ID":23236,"compounds":"[protein]-L-glutamate 5-O-methyl ester + H2O <=> H(+) + L-glutamyl-[protein] + methanol"}
{"X":2317,"KEGG":"R02625","RHEA_ID":22723,"DIRECTION":"BI","MASTER_ID":22720,"compounds":"ATP + L-histidyl-[protein] <=> ADP + H(+) + N(pros)-phospho-L-histidyl-[protein]","pmd":79.966}
{"X":2318,"KEGG":"R02626","RHEA_ID":11863,"DIRECTION":"BI","MASTER_ID":11860,"compounds":"ATP + L-histidyl-[protein] <=> ADP + H(+) + N(tele)-phospho-L-histidyl-[protein]","pmd":79.966}
{"X":2319,"KEGG":"R02627","RHEA_ID":19372,"DIRECTION":"BI","MASTER_ID":19369,"compounds":"L-histidyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":2320,"KEGG":"R02628","RHEA_ID":23883,"DIRECTION":"BI","MASTER_ID":23880,"ecocyc":"2.7.3.9-RXN","metacyc":"2.7.3.9-RXN","compounds":"L-histidyl-[protein] + phosphoenolpyruvate <=> N(pros)-phospho-L-histidyl-[protein] + pyruvate"}
{"X":2321,"KEGG":"R02630","RHEA_ID":49235,"DIRECTION":"BI","MASTER_ID":49232,"compounds":"D-mannose(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-mannose 6-phosphate(in) + L-histidyl-[protein]","pmd":79.966}
{"X":2322,"KEGG":"R02631","RHEA_ID":37362,"DIRECTION":"BI","MASTER_ID":37359,"compounds":"D-glucosamine(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-glucosamine 6-phosphate(in) + L-histidyl-[protein]","pmd":79.966}
{"X":2323,"KEGG":"R02632","RHEA_ID":22507,"DIRECTION":"BI","MASTER_ID":22504,"compounds":"3'-phosphoadenylyl sulfate + quercetin 3-sulfate <=> adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3'-bissulfate","pmd":45.03}
{"X":2324,"KEGG":"R02633","RHEA_ID":17208,"DIRECTION":"BI","MASTER_ID":17205,"compounds":"3'-phosphoadenylyl sulfate + quercetin 3-sulfate <=> adenosine 3',5'-bisphosphate + H(+) + quercetin 3,4'-bissulfate","pmd":45.03}
{"X":2325,"KEGG":"R02636","RHEA_ID":19728,"DIRECTION":"BI","MASTER_ID":19725,"compounds":"H(+) + UDP-alpha-D-galacturonate <=> CO2 + UDP-beta-L-arabinopyranose","pmd":43.99}
{"X":2326,"KEGG":"R02637","RHEA_ID":21927,"DIRECTION":"BI","MASTER_ID":21924,"metacyc":"3-DEHYDRO-L-GULONATE-2-DEHYDROGENASE-RXN","compounds":"3-dehydro-L-gulonate + NAD(+) <=> 2,3-dioxo-L-gulonate + H(+) + NADH","pmd":472.09}
{"X":2327,"KEGG":"R02637","RHEA_ID":21927,"DIRECTION":"BI","MASTER_ID":21924,"metacyc":"3-DEHYDRO-L-GULONATE-2-DEHYDROGENASE-RXN","compounds":"3-dehydro-L-gulonate + NAD(+) <=> 2,3-dioxo-L-gulonate + H(+) + NADH","pmd":2.016}
{"X":2328,"KEGG":"R02639","RHEA_ID":21931,"DIRECTION":"BI","MASTER_ID":21928,"metacyc":"3-DEHYDRO-L-GULONATE-2-DEHYDROGENASE-RXN","compounds":"3-dehydro-L-gulonate + NADP(+) <=> 2,3-dioxo-L-gulonate + H(+) + NADPH","pmd":2.016}
{"X":2329,"KEGG":"R02639","RHEA_ID":21931,"DIRECTION":"BI","MASTER_ID":21928,"metacyc":"3-DEHYDRO-L-GULONATE-2-DEHYDROGENASE-RXN","compounds":"3-dehydro-L-gulonate + NADP(+) <=> 2,3-dioxo-L-gulonate + H(+) + NADPH","pmd":552.056}
{"X":2330,"KEGG":"R02640","RHEA_ID":12892,"DIRECTION":"BI","MASTER_ID":12889,"metacyc":"L-GULONATE-3-DEHYDROGENASE-RXN","compounds":"L-gulonate + NAD(+) <=> 3-dehydro-L-gulonate + H(+) + NADH","pmd":2.016}
{"X":2331,"KEGG":"R02640","RHEA_ID":12892,"DIRECTION":"BI","MASTER_ID":12889,"metacyc":"L-GULONATE-3-DEHYDROGENASE-RXN","compounds":"L-gulonate + NAD(+) <=> 3-dehydro-L-gulonate + H(+) + NADH","pmd":470.074}
{"X":2332,"KEGG":"R02642","RHEA_ID":24175,"DIRECTION":"BI","MASTER_ID":24172,"metacyc":"3-OXO-5-BETA-STEROID-4-DEHYDROGENASE-RXN","compounds":"A + a 3-oxo-5beta-steroid <=> a 3-oxo-Delta(4)-steroid + AH2","pmd":2.016}
{"X":2333,"KEGG":"R02643","RHEA_ID":13808,"DIRECTION":"BI","MASTER_ID":13805,"metacyc":"RXN-13682","compounds":"A + a 3-oxo-5alpha-steroid <=> a 3-oxo-Delta(4)-steroid + AH2","pmd":2.016}
{"X":2334,"KEGG":"R02644","RHEA_ID":14712,"DIRECTION":"BI","MASTER_ID":14709,"metacyc":"STEROID-DELTA-ISOMERASE-RXN","compounds":"a 3-oxo-Delta(5)-steroid <=> a 3-oxo-Delta(4)-steroid","pmd":0}
{"X":2335,"KEGG":"R02646","RHEA_ID":13912,"DIRECTION":"BI","MASTER_ID":13909,"compounds":"phosphate + urate D-ribonucleoside <=> alpha-D-ribose 1-phosphate + urate","pmd":70.051}
{"X":2336,"KEGG":"R02648","RHEA_ID":16496,"DIRECTION":"BI","MASTER_ID":16493,"compounds":"glycerol 1,2-cyclic phosphate + H2O <=> glycerol 1-phosphate + H(+)","pmd":18.011}
{"X":2337,"KEGG":"R02649","RHEA_ID":14632,"DIRECTION":"BI","MASTER_ID":14629,"metacyc":"ACETYLGLUTKIN-RXN","compounds":"ATP + N-acetyl-L-glutamate <=> ADP + N-acetyl-L-glutamyl 5-phosphate","pmd":79.966}
{"X":2338,"KEGG":"R02650","RHEA_ID":23835,"DIRECTION":"BI","MASTER_ID":23832,"metacyc":"N-ACYLMANNOSAMINE-KINASE-RXN","compounds":"an N-acyl-D-mannosamine + ATP <=> ADP + an N-acyl-D-mannosamine 6-phosphate + H(+)","pmd":79.966}
{"X":2339,"KEGG":"R02651","RHEA_ID":11543,"DIRECTION":"BI","MASTER_ID":11540,"metacyc":"N-ACYLMANNOSAMINE-1-DEHYDROGENASE-RXN","compounds":"an N-acyl-D-mannosamine + NAD(+) <=> an N-acyl-D-mannosaminolactone + H(+) + NADH"}
{"X":2340,"KEGG":"R02652","RHEA_ID":19036,"DIRECTION":"BI","MASTER_ID":19033,"metacyc":"N-ACYLGLUCOSAMINE-2-EPIMERASE-RXN","compounds":"an N-acyl-D-glucosamine <=> an N-acyl-D-mannosamine"}
{"X":2341,"KEGG":"R02654","RHEA_ID":14792,"DIRECTION":"BI","MASTER_ID":14789,"metacyc":"2.4.1.198-RXN","compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine <=> a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP","pmd":203.079}
{"X":2342,"KEGG":"R02656","RHEA_ID":18240,"DIRECTION":"BI","MASTER_ID":18237,"compounds":"2,5-dihydroxybenzoate + O2 <=> 3-maleylpyruvate + H(+)","pmd":31.99}
{"X":2343,"KEGG":"R02658","RHEA_ID":10791,"DIRECTION":"BI","MASTER_ID":10788,"compounds":"2-dehydro-D-gluconate + ATP <=> 6-phospho-2-dehydro-D-gluconate + ADP + H(+)","pmd":79.966}
{"X":2344,"KEGG":"R02661","RHEA_ID":31098,"DIRECTION":"BI","MASTER_ID":31095,"compounds":"2-methylpropanoyl-CoA + A <=> (2E)-2-methylpropenoyl-CoA + AH2","pmd":2.016}
{"X":2345,"KEGG":"R02662","RHEA_ID":18868,"DIRECTION":"BI","MASTER_ID":18865,"compounds":"(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2-methylpropanoyl-CoA <=> (R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysyl-[protein] + CoA","pmd":70.042}
{"X":2346,"KEGG":"R02664","RHEA_ID":42411,"DIRECTION":"BI","MASTER_ID":42408,"compounds":"(2R)-2-phosphoglycerate + ATP <=> (2R)-2,3-bisphosphoglycerate + ADP + H(+)","pmd":79.966}
{"X":2347,"KEGG":"R02665","RHEA_ID":17956,"DIRECTION":"BI","MASTER_ID":17953,"compounds":"3-hydroxyanthranilate + O2 <=> (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde","pmd":31.99}
{"X":2348,"KEGG":"R02666","RHEA_ID":17248,"DIRECTION":"BI","MASTER_ID":17245,"compounds":"3-hydroxyanthranilate + O2 <=> 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2","pmd":2.016}
{"X":2349,"KEGG":"R02667","RHEA_ID":17836,"DIRECTION":"BI","MASTER_ID":17833,"compounds":"3-hydroxyanthranilate + S-adenosyl-L-methionine <=> 3-hydroxy-4-methylanthranilate + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":2350,"KEGG":"R02668","RHEA_ID":25146,"DIRECTION":"BI","MASTER_ID":25143,"compounds":"3-hydroxy-L-kynurenine + H2O <=> 3-hydroxyanthranilate + H(+) + L-alanine","pmd":71.037}
{"X":2351,"KEGG":"R02673","RHEA_ID":15836,"DIRECTION":"BI","MASTER_ID":15833,"compounds":"(S)-4-hydroxymandelate + H(+) + O2 <=> 4-hydroxybenzaldehyde + CO2 + H2O2","pmd":46.006}
{"X":2352,"KEGG":"R02676","RHEA_ID":15980,"DIRECTION":"BI","MASTER_ID":15977,"compounds":"(S)-4-hydroxymandelonitrile <=> 4-hydroxybenzaldehyde + hydrogen cyanide","pmd":27.011}
{"X":2353,"KEGG":"R02678","RHEA_ID":30870,"DIRECTION":"BI","MASTER_ID":30867,"compounds":"H2O + indole-3-acetaldehyde + NAD(+) <=> (indol-3-yl)acetate + 2 H(+) + NADH","pmd":489.054}
{"X":2354,"KEGG":"R02678","RHEA_ID":30870,"DIRECTION":"BI","MASTER_ID":30867,"compounds":"H2O + indole-3-acetaldehyde + NAD(+) <=> (indol-3-yl)acetate + 2 H(+) + NADH","pmd":15.995}
{"X":2355,"KEGG":"R02679","RHEA_ID":14876,"DIRECTION":"BI","MASTER_ID":14873,"compounds":"indole-3-ethanol + NAD(+) <=> H(+) + indole-3-acetaldehyde + NADH","pmd":2.016}
{"X":2356,"KEGG":"R02679","RHEA_ID":14876,"DIRECTION":"BI","MASTER_ID":14873,"compounds":"indole-3-ethanol + NAD(+) <=> H(+) + indole-3-acetaldehyde + NADH","pmd":505.048}
{"X":2357,"KEGG":"R02680","RHEA_ID":17040,"DIRECTION":"BI","MASTER_ID":17037,"metacyc":"1.1.1.191-RXN","compounds":"indole-3-ethanol + NADP(+) <=> H(+) + indole-3-acetaldehyde + NADPH","pmd":585.015}
{"X":2358,"KEGG":"R02680","RHEA_ID":17040,"DIRECTION":"BI","MASTER_ID":17037,"metacyc":"1.1.1.191-RXN","compounds":"indole-3-ethanol + NADP(+) <=> H(+) + indole-3-acetaldehyde + NADPH","pmd":2.016}
{"X":2359,"KEGG":"R02681","RHEA_ID":16280,"DIRECTION":"BI","MASTER_ID":16277,"compounds":"H2O + indole-3-acetaldehyde + O2 <=> (indol-3-yl)acetate + H(+) + H2O2","pmd":15.995}
{"X":2360,"KEGG":"R02682","RHEA_ID":16644,"DIRECTION":"BI","MASTER_ID":16641,"compounds":"a long-chain fatty acyl ethyl ester + H2O <=> a long-chain fatty acid + ethanol + H(+)"}
{"X":2361,"KEGG":"R02684","RHEA_ID":10143,"DIRECTION":"BI","MASTER_ID":10140,"metacyc":"1.1.1.188-RXN","compounds":"NADP(+) + prostaglandin F2alpha <=> H(+) + NADPH + prostaglandin D2","pmd":391.858}
{"X":2362,"KEGG":"R02684","RHEA_ID":10143,"DIRECTION":"BI","MASTER_ID":10140,"metacyc":"1.1.1.188-RXN","compounds":"NADP(+) + prostaglandin F2alpha <=> H(+) + NADPH + prostaglandin D2","pmd":2.016}
{"X":2363,"KEGG":"R02685","RHEA_ID":16108,"DIRECTION":"BI","MASTER_ID":16105,"compounds":"a (3S)-hydroxyacyl-CoA <=> a (2E)-enoyl-CoA + H2O"}
{"X":2364,"KEGG":"R02689","RHEA_ID":17288,"DIRECTION":"BI","MASTER_ID":17285,"compounds":"a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose <=> a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + H(+) + UDP","pmd":162.053}
{"X":2365,"KEGG":"R02691","RHEA_ID":14948,"DIRECTION":"BI","MASTER_ID":14945,"compounds":"a 1,2-diacyl-sn-glycerol + UDP-alpha-D-galactose <=> a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) + UDP","pmd":162.053}
{"X":2366,"KEGG":"R02692","RHEA_ID":34090,"DIRECTION":"BI","MASTER_ID":34087,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + cholesterol <=> a 1-acyl-sn-glycero-3-phosphocholine + a cholesterol ester"}
{"X":2367,"KEGG":"R02693","RHEA_ID":13304,"DIRECTION":"BI","MASTER_ID":13301,"metacyc":"2.3.1.73-RXN","compounds":"a 1,2-diacyl-sn-glycerol + a sterol <=> a 1-acyl-sn-glycerol + a sterol ester"}
{"X":2368,"KEGG":"R02695","RHEA_ID":17276,"DIRECTION":"BI","MASTER_ID":17273,"compounds":"(4-hydroxyphenyl)acetaldehyde + H2O + NAD(+) <=> 4-hydroxyphenylacetate + 2 H(+) + NADH","pmd":512.07}
{"X":2369,"KEGG":"R02695","RHEA_ID":17276,"DIRECTION":"BI","MASTER_ID":17273,"compounds":"(4-hydroxyphenyl)acetaldehyde + H2O + NAD(+) <=> 4-hydroxyphenylacetate + 2 H(+) + NADH","pmd":15.995}
{"X":2370,"KEGG":"R02698","RHEA_ID":16684,"DIRECTION":"BI","MASTER_ID":16681,"compounds":"4-hydroxyphenylacetate + H(+) + NADH + O2 <=> 3,4-dihydroxyphenylacetate + H2O + NAD(+)","pmd":497.083}
{"X":2371,"KEGG":"R02698","RHEA_ID":16684,"DIRECTION":"BI","MASTER_ID":16681,"compounds":"4-hydroxyphenylacetate + H(+) + NADH + O2 <=> 3,4-dihydroxyphenylacetate + H2O + NAD(+)","pmd":15.995}
{"X":2372,"KEGG":"R02701","RHEA_ID":18536,"DIRECTION":"BI","MASTER_ID":18533,"compounds":"5-hydroxy-L-tryptophan + H(+) <=> CO2 + serotonin","pmd":43.99}
{"X":2373,"KEGG":"R02704","RHEA_ID":33366,"DIRECTION":"BI","MASTER_ID":33363,"compounds":"D-mannitol(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-mannitol 1-phosphate(in) + L-histidyl-[protein]","pmd":79.966}
{"X":2374,"KEGG":"R02705","RHEA_ID":25256,"DIRECTION":"BI","MASTER_ID":25253,"compounds":"ATP + N-acetyl-D-mannosamine <=> ADP + H(+) + N-acetyl-D-mannosamine 6-phosphate","pmd":79.966}
{"X":2375,"KEGG":"R02708","RHEA_ID":50735,"DIRECTION":"BI","MASTER_ID":50732,"compounds":"4-hydroxyphenylacetonitrile + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-4-hydroxymandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":2376,"KEGG":"R02708","RHEA_ID":23743,"DIRECTION":"BI","MASTER_ID":23740,"metacyc":"1.14.13.42-RXN","compounds":"4-hydroxyphenylacetonitrile + H(+) + NADPH + O2 <=> 4-hydroxymandelonitrile + H2O + NADP(+)","pmd":15.995}
{"X":2377,"KEGG":"R02709","RHEA_ID":15964,"DIRECTION":"BI","MASTER_ID":15961,"compounds":"4-hydroxymandelonitrile + UDP-alpha-D-glucose <=> H(+) + taxiphyllin + UDP","pmd":162.053}
{"X":2378,"KEGG":"R02711","RHEA_ID":13856,"DIRECTION":"BI","MASTER_ID":13853,"compounds":"4-methylene-L-glutamate + ATP + NH4(+) <=> 4-methylene-L-glutamine + AMP + diphosphate + H(+)","pmd":0.984}
{"X":2379,"KEGG":"R02711","RHEA_ID":13856,"DIRECTION":"BI","MASTER_ID":13853,"compounds":"4-methylene-L-glutamate + ATP + NH4(+) <=> 4-methylene-L-glutamine + AMP + diphosphate + H(+)","pmd":159.933}
{"X":2380,"KEGG":"R02712","RHEA_ID":14744,"DIRECTION":"BI","MASTER_ID":14741,"compounds":"4-methylene-L-glutamine + H2O <=> 4-methylene-L-glutamate + NH4(+)","pmd":0.984}
{"X":2381,"KEGG":"R02714","RHEA_ID":23111,"DIRECTION":"BI","MASTER_ID":23108,"compounds":"D-arabinono-1,4-lactone + H2O <=> D-arabinonate + H(+)","pmd":18.01}
{"X":2382,"KEGG":"R02715","RHEA_ID":23759,"DIRECTION":"BI","MASTER_ID":23756,"metacyc":"1.1.3.37-RXN","compounds":"D-arabinono-1,4-lactone + O2 <=> dehydro-D-arabinono-1,4-lactone + H(+) + H2O2","pmd":2.016}
{"X":2383,"KEGG":"R02717","RHEA_ID":21015,"DIRECTION":"BI","MASTER_ID":21012,"compounds":"4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine <=> 4-O-([2-N-acetyl-alpha-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP","pmd":203.079}
{"X":2384,"KEGG":"R02719","RHEA_ID":28533,"DIRECTION":"BI","MASTER_ID":28530,"compounds":"H2O + XMP <=> phosphate + xanthosine","pmd":79.966}
{"X":2385,"KEGG":"R02720","RHEA_ID":28613,"DIRECTION":"BI","MASTER_ID":28610,"compounds":"H2O + XTP <=> diphosphate + H(+) + XMP","pmd":159.933}
{"X":2386,"KEGG":"R02722","RHEA_ID":10535,"DIRECTION":"BI","MASTER_ID":10532,"compounds":"(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine <=> D-glyceraldehyde 3-phosphate + H2O + L-tryptophan","pmd":64.955}
{"X":2387,"KEGG":"R02722","RHEA_ID":10535,"DIRECTION":"BI","MASTER_ID":10532,"compounds":"(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine <=> D-glyceraldehyde 3-phosphate + H2O + L-tryptophan","pmd":82.966}
{"X":2388,"KEGG":"R02723","RHEA_ID":34338,"DIRECTION":"BI","MASTER_ID":34335,"compounds":"cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 22R-hydroxycholesterol + H2O + 2 oxidized [adrenodoxin]","pmd":15.995}
{"X":2389,"KEGG":"R02724","RHEA_ID":35742,"DIRECTION":"BI","MASTER_ID":35739,"compounds":"cholesterol + 6 H(+) + 3 O2 + 6 reduced [adrenodoxin] <=> 4-methylpentanal + 4 H2O + 6 oxidized [adrenodoxin] + pregnenolone","pmd":70.115}
{"X":2390,"KEGG":"R02726","RHEA_ID":15632,"DIRECTION":"BI","MASTER_ID":15629,"compounds":"a steroid + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> an 11beta-hydroxysteroid + H2O + 2 oxidized [adrenodoxin]"}
{"X":2391,"KEGG":"R02727","RHEA_ID":23515,"DIRECTION":"BI","MASTER_ID":23512,"metacyc":"ALPHAALPHA-TREHALOSE-PHOSPHORYLASE-RXN","compounds":"alpha,alpha-trehalose + phosphate <=> beta-D-glucose 1-phosphate + D-glucose","pmd":82.087}
{"X":2392,"KEGG":"R02728","RHEA_ID":20116,"DIRECTION":"BI","MASTER_ID":20113,"ecocyc":"BETA-PHOSPHOGLUCOMUTASE-RXN","metacyc":"BETA-PHOSPHOGLUCOMUTASE-RXN","compounds":"beta-D-glucose 1-phosphate <=> beta-D-glucose 6-phosphate","pmd":0}
{"X":2393,"KEGG":"R02729","RHEA_ID":24291,"DIRECTION":"BI","MASTER_ID":24288,"metacyc":"GLYCINE-FORMIMINOTRANSFERASE-RXN","compounds":"5-formimidoyltetrahydrofolate + glycine <=> (6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine","pmd":27.011}
{"X":2394,"KEGG":"R02730","RHEA_ID":13336,"DIRECTION":"BI","MASTER_ID":13333,"compounds":"beta-D-fructose 2,6-bisphosphate + H2O <=> beta-D-fructose 2-phosphate + phosphate","pmd":79.966}
{"X":2395,"KEGG":"R02732","RHEA_ID":15656,"DIRECTION":"BI","MASTER_ID":15653,"metacyc":"6-PHOSPHOFRUCTO-2-KINASE-RXN","compounds":"ATP + beta-D-fructose 6-phosphate <=> ADP + beta-D-fructose 2,6-bisphosphate + H(+)","pmd":79.966}
{"X":2396,"KEGG":"R02733","RHEA_ID":20408,"DIRECTION":"BI","MASTER_ID":20405,"compounds":"H2O + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate <=> (2S,6S)-2,6-diaminoheptanedioate + acetate","pmd":42.01}
{"X":2397,"KEGG":"R02734","RHEA_ID":22611,"DIRECTION":"BI","MASTER_ID":22608,"ecocyc":"SUCCDIAMINOPIMDESUCC-RXN","metacyc":"SUCCDIAMINOPIMDESUCC-RXN","compounds":"H2O + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate <=> (2S,6S)-2,6-diaminoheptanedioate + succinate","pmd":100.016}
{"X":2398,"KEGG":"R02735","RHEA_ID":15396,"DIRECTION":"BI","MASTER_ID":15393,"ecocyc":"DIAMINOPIMEPIM-RXN","metacyc":"DIAMINOPIMEPIM-RXN","compounds":"(2S,6S)-2,6-diaminoheptanedioate <=> meso-2,6-diaminoheptanedioate","pmd":0}
{"X":2399,"KEGG":"R02738","RHEA_ID":33370,"DIRECTION":"BI","MASTER_ID":33367,"compounds":"D-glucose(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-glucose 6-phosphate(in) + L-histidyl-[protein]","pmd":79.966}
{"X":2400,"KEGG":"R02739","RHEA_ID":16252,"DIRECTION":"BI","MASTER_ID":16249,"ecocyc":"GLUCOSE-6-PHOSPHATE-1-EPIMERASE-RXN","metacyc":"GLUCOSE-6-PHOSPHATE-1-EPIMERASE-RXN","compounds":"alpha-D-glucose 6-phosphate <=> beta-D-glucose 6-phosphate","pmd":0}
{"X":2401,"KEGG":"R02741","RHEA_ID":17996,"DIRECTION":"BI","MASTER_ID":17993,"metacyc":"HOMOGLUTATHIONE-SYNTHASE-RXN","compounds":"ATP + beta-alanine + L-gamma-glutamyl-L-cysteine <=> ADP + gamma-L-glutamyl-L-cysteinyl-beta-alanine + H(+) + phosphate","pmd":71.037}
{"X":2402,"KEGG":"R02741","RHEA_ID":17996,"DIRECTION":"BI","MASTER_ID":17993,"metacyc":"HOMOGLUTATHIONE-SYNTHASE-RXN","compounds":"ATP + beta-alanine + L-gamma-glutamyl-L-cysteine <=> ADP + gamma-L-glutamyl-L-cysteinyl-beta-alanine + H(+) + phosphate","pmd":79.966}
{"X":2403,"KEGG":"R02742","RHEA_ID":11983,"DIRECTION":"BI","MASTER_ID":11980,"compounds":"2 L-gamma-glutamyl-L-cysteine + NADP(+) <=> bis-gamma-glutamylcystine + H(+) + NADPH","pmd":245.974}
{"X":2404,"KEGG":"R02742","RHEA_ID":11983,"DIRECTION":"BI","MASTER_ID":11980,"compounds":"2 L-gamma-glutamyl-L-cysteine + NADP(+) <=> bis-gamma-glutamylcystine + H(+) + NADPH","pmd":248.047}
{"X":2405,"KEGG":"R02745","RHEA_ID":22547,"DIRECTION":"BI","MASTER_ID":22544,"metacyc":"3.3.2.2-RXN","compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O <=> a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine"}
{"X":2406,"KEGG":"R02746","RHEA_ID":15180,"DIRECTION":"BI","MASTER_ID":15177,"compounds":"a 1-acyl-sn-glycero-3-phosphocholine + H2O <=> a fatty acid + H(+) + sn-glycerol 3-phosphocholine"}
{"X":2407,"KEGG":"R02748","RHEA_ID":27753,"DIRECTION":"BI","MASTER_ID":27750,"ecocyc":"DEOXYINOPHOSPHOR-RXN","metacyc":"RXN-11742","compounds":"2'-deoxyinosine + phosphate <=> 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine","pmd":38.062}
{"X":2408,"KEGG":"R02748","RHEA_ID":27753,"DIRECTION":"BI","MASTER_ID":27750,"ecocyc":"DEOXYINOPHOSPHOR-RXN","metacyc":"DEOXYINOPHOSPHOR-RXN","compounds":"2'-deoxyinosine + phosphate <=> 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine","pmd":38.062}
{"X":2409,"KEGG":"R02749","RHEA_ID":27661,"DIRECTION":"BI","MASTER_ID":27658,"ecocyc":"D-PPENTOMUT-RXN","metacyc":"D-PPENTOMUT-RXN","compounds":"2-deoxy-alpha-D-ribose 1-phosphate <=> 2-deoxy-D-ribose 5-phosphate","pmd":0}
{"X":2410,"KEGG":"R02750","RHEA_ID":30874,"DIRECTION":"BI","MASTER_ID":30871,"compounds":"2-deoxy-D-ribose + ATP <=> 2-deoxy-D-ribose 5-phosphate + ADP + H(+)","pmd":79.966}
{"X":2411,"KEGG":"R02751","RHEA_ID":10095,"DIRECTION":"BI","MASTER_ID":10092,"compounds":"a 2'-deoxyribonucleoside 3'-phosphate + H2O <=> a 2'-deoxyribonucleoside + phosphate"}
{"X":2412,"KEGG":"R02752","RHEA_ID":14576,"DIRECTION":"BI","MASTER_ID":14573,"compounds":"D-glucarate <=> 5-dehydro-4-deoxy-D-glucarate + H2O","pmd":18.011}
{"X":2413,"KEGG":"R02754","RHEA_ID":27729,"DIRECTION":"BI","MASTER_ID":27726,"ecocyc":"KDGALDOL-RXN","metacyc":"KDGALDOL-RXN","compounds":"5-dehydro-4-deoxy-D-glucarate <=> 2-hydroxy-3-oxopropanoate + pyruvate","pmd":88.016}
{"X":2414,"KEGG":"R02755","RHEA_ID":13564,"DIRECTION":"BI","MASTER_ID":13561,"metacyc":"DIAMINOPIMELATE-DEHYDROGENASE-RXN","compounds":"H2O + meso-2,6-diaminoheptanedioate + NADP(+) <=> (S)-2-amino-6-oxoheptanedioate + H(+) + NADPH + NH4(+)","pmd":555.02}
{"X":2415,"KEGG":"R02755","RHEA_ID":13564,"DIRECTION":"BI","MASTER_ID":13561,"metacyc":"DIAMINOPIMELATE-DEHYDROGENASE-RXN","compounds":"H2O + meso-2,6-diaminoheptanedioate + NADP(+) <=> (S)-2-amino-6-oxoheptanedioate + H(+) + NADPH + NH4(+)","pmd":1.032}
{"X":2416,"KEGG":"R02762","RHEA_ID":34222,"DIRECTION":"BI","MASTER_ID":34219,"compounds":"(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O + NAD(+) <=> (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+) + NADH","pmd":15.995}
{"X":2417,"KEGG":"R02762","RHEA_ID":34222,"DIRECTION":"BI","MASTER_ID":34219,"compounds":"(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O + NAD(+) <=> (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+) + NADH","pmd":506.095}
{"X":2418,"KEGG":"R02764","RHEA_ID":17348,"DIRECTION":"BI","MASTER_ID":17345,"compounds":"(S)-methylmalonyl-CoA + H2O <=> CoA + H(+) + methylmalonate","pmd":100.016}
{"X":2419,"KEGG":"R02765","RHEA_ID":20556,"DIRECTION":"BI","MASTER_ID":20553,"ecocyc":"METHYLMALONYL-COA-EPIM-RXN","metacyc":"METHYLMALONYL-COA-EPIM-RXN","compounds":"(R)-methylmalonyl-CoA <=> (S)-methylmalonyl-CoA","pmd":0}
{"X":2420,"KEGG":"R02766","RHEA_ID":19916,"DIRECTION":"BI","MASTER_ID":19913,"metacyc":"1.1.1.212-RXN","compounds":"a (3R)-hydroxyacyl-[ACP] + NAD(+) <=> a 3-oxoacyl-[ACP] + H(+) + NADH"}
{"X":2421,"KEGG":"R02767","RHEA_ID":17400,"DIRECTION":"BI","MASTER_ID":17397,"compounds":"a (3R)-hydroxyacyl-[ACP] + NADP(+) <=> a 3-oxoacyl-[ACP] + H(+) + NADPH"}
{"X":2422,"KEGG":"R02768","RHEA_ID":22839,"DIRECTION":"BI","MASTER_ID":22836,"compounds":"a fatty acyl-[ACP] + H(+) + malonyl-[ACP] <=> a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]"}
{"X":2423,"KEGG":"R02769","RHEA_ID":13424,"DIRECTION":"BI","MASTER_ID":13421,"compounds":"an N-acyl-D-mannosamine 6-phosphate + H2O + phosphoenolpyruvate <=> an N-acylneuraminate 9-phosphate + phosphate"}
{"X":2424,"KEGG":"R02770","RHEA_ID":23935,"DIRECTION":"BI","MASTER_ID":23932,"metacyc":"5.1.3.9-RXN","compounds":"an N-acyl-D-glucosamine 6-phosphate <=> an N-acyl-D-mannosamine 6-phosphate"}
{"X":2425,"KEGG":"R02773","RHEA_ID":19088,"DIRECTION":"BI","MASTER_ID":19085,"metacyc":"2.6.1.33-RXN","compounds":"2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-glucose <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate","pmd":1.032}
{"X":2426,"KEGG":"R02776","RHEA_ID":23651,"DIRECTION":"BI","MASTER_ID":23648,"compounds":"dTDP-6-deoxy-beta-L-talose + NADP(+) <=> dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH","pmd":2.016}
{"X":2427,"KEGG":"R02776","RHEA_ID":23651,"DIRECTION":"BI","MASTER_ID":23648,"compounds":"dTDP-6-deoxy-beta-L-talose + NADP(+) <=> dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH","pmd":198.018}
{"X":2428,"KEGG":"R02777","RHEA_ID":21799,"DIRECTION":"BI","MASTER_ID":21796,"ecocyc":"DTDPDEHYRHAMREDUCT-RXN","metacyc":"DTDPDEHYRHAMREDUCT-RXN","compounds":"dTDP-beta-L-rhamnose + NADP(+) <=> dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH","pmd":2.016}
{"X":2429,"KEGG":"R02777","RHEA_ID":21799,"DIRECTION":"BI","MASTER_ID":21796,"ecocyc":"DTDPDEHYRHAMREDUCT-RXN","metacyc":"DTDPDEHYRHAMREDUCT-RXN","compounds":"dTDP-beta-L-rhamnose + NADP(+) <=> dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH","pmd":198.018}
{"X":2430,"KEGG":"R02778","RHEA_ID":23423,"DIRECTION":"BI","MASTER_ID":23420,"metacyc":"TREHALOSEPHOSPHA-RXN","compounds":"alpha,alpha-trehalose 6-phosphate + H2O <=> alpha,alpha-trehalose + phosphate","pmd":79.966}
{"X":2431,"KEGG":"R02780","RHEA_ID":33374,"DIRECTION":"BI","MASTER_ID":33371,"compounds":"alpha,alpha-trehalose(out) + N(pros)-phospho-L-histidyl-[protein] <=> alpha,alpha-trehalose 6-phosphate(in) + L-histidyl-[protein]","pmd":79.966}
{"X":2432,"KEGG":"R02781","RHEA_ID":22923,"DIRECTION":"BI","MASTER_ID":22920,"metacyc":"2.6.1.50-RXN","compounds":"L-glutamine + scyllo-inosose <=> 1-amino-1-deoxy-scyllo-inositol + 2-oxoglutaramate","pmd":1.032}
{"X":2433,"KEGG":"R02782","RHEA_ID":14068,"DIRECTION":"BI","MASTER_ID":14065,"compounds":"scyllo-inosose <=> 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O","pmd":18.01}
{"X":2434,"KEGG":"R02783","RHEA_ID":16432,"DIRECTION":"BI","MASTER_ID":16429,"compounds":"ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate","pmd":279.976}
{"X":2435,"KEGG":"R02783","RHEA_ID":16432,"DIRECTION":"BI","MASTER_ID":16429,"compounds":"ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate","pmd":79.966}
{"X":2436,"KEGG":"R02783","RHEA_ID":16432,"DIRECTION":"BI","MASTER_ID":16429,"compounds":"ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate","pmd":129.043}
{"X":2437,"KEGG":"R02786","RHEA_ID":17972,"DIRECTION":"BI","MASTER_ID":17969,"compounds":"ATP + L-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine","pmd":452.153}
{"X":2438,"KEGG":"R02786","RHEA_ID":17972,"DIRECTION":"BI","MASTER_ID":17969,"compounds":"ATP + L-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine","pmd":280.924}
{"X":2439,"KEGG":"R02786","RHEA_ID":17972,"DIRECTION":"BI","MASTER_ID":17969,"compounds":"ATP + L-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine","pmd":79.966}
{"X":2440,"KEGG":"R02788","RHEA_ID":23679,"DIRECTION":"BI","MASTER_ID":23676,"compounds":"ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate","pmd":79.966}
{"X":2441,"KEGG":"R02788","RHEA_ID":23679,"DIRECTION":"BI","MASTER_ID":23676,"compounds":"ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate","pmd":452.153}
{"X":2442,"KEGG":"R02788","RHEA_ID":23679,"DIRECTION":"BI","MASTER_ID":23676,"compounds":"ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate","pmd":236.934}
{"X":2443,"KEGG":"R02789","RHEA_ID":14392,"DIRECTION":"BI","MASTER_ID":14389,"compounds":"a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine <=> an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP","pmd":203.079}
{"X":2444,"KEGG":"R02790","RHEA_ID":17416,"DIRECTION":"BI","MASTER_ID":17413,"compounds":"a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine <=> an N-acetyl-beta-D-glucosaminyl-(1->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP","pmd":203.079}
{"X":2445,"KEGG":"R02791","RHEA_ID":13016,"DIRECTION":"BI","MASTER_ID":13013,"compounds":"a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose <=> an alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP","pmd":162.053}
{"X":2446,"KEGG":"R02792","RHEA_ID":19412,"DIRECTION":"BI","MASTER_ID":19409,"compounds":"cholate + NAD(+) <=> 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH","pmd":257.845}
{"X":2447,"KEGG":"R02792","RHEA_ID":19412,"DIRECTION":"BI","MASTER_ID":19409,"compounds":"cholate + NAD(+) <=> 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH","pmd":2.016}
{"X":2448,"KEGG":"R02793","RHEA_ID":14132,"DIRECTION":"BI","MASTER_ID":14129,"metacyc":"1.1.1.176-RXN","compounds":"cholate + NADP(+) <=> 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH","pmd":337.811}
{"X":2449,"KEGG":"R02793","RHEA_ID":14132,"DIRECTION":"BI","MASTER_ID":14129,"metacyc":"1.1.1.176-RXN","compounds":"cholate + NADP(+) <=> 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH","pmd":2.016}
{"X":2450,"KEGG":"R02794","RHEA_ID":23535,"DIRECTION":"BI","MASTER_ID":23532,"compounds":"ATP + cholate + CoA <=> AMP + choloyl-CoA + diphosphate","pmd":159.933}
{"X":2451,"KEGG":"R02794","RHEA_ID":23535,"DIRECTION":"BI","MASTER_ID":23532,"compounds":"ATP + cholate + CoA <=> AMP + choloyl-CoA + diphosphate","pmd":420.052}
{"X":2452,"KEGG":"R02794","RHEA_ID":23535,"DIRECTION":"BI","MASTER_ID":23532,"compounds":"ATP + cholate + CoA <=> AMP + choloyl-CoA + diphosphate","pmd":61.224}
{"X":2453,"KEGG":"R02800","RHEA_ID":20747,"DIRECTION":"BI","MASTER_ID":20744,"compounds":"NADP(+) + prostaglandin D2 <=> 15-dehydro-prostaglandin D2 + H(+) + NADPH","pmd":2.016}
{"X":2454,"KEGG":"R02800","RHEA_ID":20747,"DIRECTION":"BI","MASTER_ID":20744,"compounds":"NADP(+) + prostaglandin D2 <=> 15-dehydro-prostaglandin D2 + H(+) + NADPH","pmd":393.874}
{"X":2455,"KEGG":"R02804","RHEA_ID":15496,"DIRECTION":"BI","MASTER_ID":15493,"metacyc":"NITROUS-OXIDE-REDUCTASE-RXN","compounds":"A + H2O + N2 <=> AH2 + nitrous oxide"}
{"X":2456,"KEGG":"R02804","RHEA_ID":43111,"DIRECTION":"BI","MASTER_ID":43108,"compounds":"2 [Fe(III)cytochrome c] + H2O + N2 <=> 2 [Fe(II)cytochrome c] + 2 H(+) + nitrous oxide"}
{"X":2457,"KEGG":"R02807","RHEA_ID":23859,"DIRECTION":"BI","MASTER_ID":23856,"compounds":"H(+) + Hg + NADP(+) <=> Hg(2+) + NADPH"}
{"X":2458,"KEGG":"R02808","RHEA_ID":23139,"DIRECTION":"BI","MASTER_ID":23136,"compounds":"a primary amine + S-adenosyl-L-methionine <=> a methylated primary amine + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":2459,"KEGG":"R02809","RHEA_ID":24139,"DIRECTION":"BI","MASTER_ID":24136,"metacyc":"ARYLAMINE-SULFOTRANSFERASE-RXN","compounds":"3'-phosphoadenylyl sulfate + a primary amine <=> a sulfamate + adenosine 3',5'-bisphosphate + 2 H(+)","pmd":79.957}
{"X":2460,"KEGG":"R02810","RHEA_ID":23339,"DIRECTION":"BI","MASTER_ID":23336,"compounds":"2 H(+) + H2O2 + 2 iodide <=> diiodine + 2 H2O"}
{"X":2461,"KEGG":"R02811","RHEA_ID":56595,"DIRECTION":"BI","MASTER_ID":56592,"metacyc":"RXN-11731","compounds":"a disubstituted aliphatic (S)-hydroxynitrile <=> a ketone + hydrogen cyanide"}
{"X":2462,"KEGG":"R02813","RHEA_ID":21855,"DIRECTION":"BI","MASTER_ID":21852,"metacyc":"OLEATE-HYDRATASE-RXN","compounds":"(R)-10-hydroxyoctadecanoate <=> (9Z)-octadecenoate + H2O","pmd":18.01}
{"X":2463,"KEGG":"R02814","RHEA_ID":15060,"DIRECTION":"BI","MASTER_ID":15057,"compounds":"(9Z)-octadecenoyl-[ACP] + H2O <=> (9Z)-octadecenoate + H(+) + holo-[ACP]"}
{"X":2464,"KEGG":"R02815","RHEA_ID":11907,"DIRECTION":"BI","MASTER_ID":11904,"compounds":"2-amino-4-hydroxypteridine + H(+) + H2O <=> 2,4-dihydroxypteridine + NH4(+)","pmd":0.984}
{"X":2465,"KEGG":"R02816","RHEA_ID":12780,"DIRECTION":"BI","MASTER_ID":12777,"compounds":"2-amino-4-hydroxypteridine + O2 <=> 2-amino-4,7-dihydroxypteridine + chemical entity","pmd":15.995}
{"X":2466,"KEGG":"R02817","RHEA_ID":17116,"DIRECTION":"BI","MASTER_ID":17113,"compounds":"H2O + L-serine-phosphoethanolamine <=> H(+) + L-serine + phosphoethanolamine","pmd":87.032}
{"X":2467,"KEGG":"R02819","RHEA_ID":12788,"DIRECTION":"BI","MASTER_ID":12785,"metacyc":"ALDEHYDE-REDUCTASE-RXN","compounds":"an alditol + NAD(+) <=> an aldose + H(+) + NADH"}
{"X":2468,"KEGG":"R02820","RHEA_ID":12792,"DIRECTION":"BI","MASTER_ID":12789,"metacyc":"ALDEHYDE-REDUCTASE-RXN","compounds":"an alditol + NADP(+) <=> an aldose + H(+) + NADPH"}
{"X":2469,"KEGG":"R02821","RHEA_ID":22339,"DIRECTION":"BI","MASTER_ID":22336,"compounds":"betaine + L-homocysteine <=> L-methionine + N,N-dimethylglycine","pmd":14.016}
{"X":2470,"KEGG":"R02822","RHEA_ID":19040,"DIRECTION":"BI","MASTER_ID":19037,"metacyc":"3.3.2.10-RXN","compounds":"an epoxide + H2O <=> an ethanediol"}
{"X":2471,"KEGG":"R02825","RHEA_ID":12740,"DIRECTION":"BI","MASTER_ID":12737,"compounds":"5-aminopentanoate + [PrdC protein]-Se-L-selenocysteinyl-S-L-cysteine <=> [PrdC protein]-L-selenocysteine/L-cysteine + D-proline","pmd":2.016}
{"X":2472,"KEGG":"R02826","RHEA_ID":12676,"DIRECTION":"BI","MASTER_ID":12673,"metacyc":"NITRILE-HYDRATASE-RXN","compounds":"an aliphatic amide <=> a nitrile + H2O"}
{"X":2473,"KEGG":"R02827","RHEA_ID":11319,"DIRECTION":"BI","MASTER_ID":11316,"compounds":"an aliphatic aldoxime <=> a nitrile + H2O"}
{"X":2474,"KEGG":"R02830","RHEA_ID":19604,"DIRECTION":"BI","MASTER_ID":19601,"compounds":"H(+) + NADH + O2 + orcinol <=> 2,3,5-trihydroxytoluene + H2O + NAD(+)","pmd":15.995}
{"X":2475,"KEGG":"R02830","RHEA_ID":19604,"DIRECTION":"BI","MASTER_ID":19601,"compounds":"H(+) + NADH + O2 + orcinol <=> 2,3,5-trihydroxytoluene + H2O + NAD(+)","pmd":525.078}
{"X":2476,"KEGG":"R02831","RHEA_ID":16736,"DIRECTION":"BI","MASTER_ID":16733,"compounds":"H(+) + orsellinate <=> CO2 + orcinol","pmd":43.99}
{"X":2477,"KEGG":"R02832","RHEA_ID":18360,"DIRECTION":"BI","MASTER_ID":18357,"metacyc":"TROPINE-DEHYDROGENASE-RXN","compounds":"NADP(+) + tropine <=> H(+) + NADPH + tropinone","pmd":2.016}
{"X":2478,"KEGG":"R02832","RHEA_ID":18360,"DIRECTION":"BI","MASTER_ID":18357,"metacyc":"TROPINE-DEHYDROGENASE-RXN","compounds":"NADP(+) + tropine <=> H(+) + NADPH + tropinone","pmd":604.984}
{"X":2479,"KEGG":"R02837","RHEA_ID":17076,"DIRECTION":"BI","MASTER_ID":17073,"compounds":"acetyl-CoA + cortisol <=> CoA + cortisol 21-acetate","pmd":42.011}
{"X":2480,"KEGG":"R02839","RHEA_ID":11887,"DIRECTION":"BI","MASTER_ID":11884,"metacyc":"CORTISOL-SULFOTRANSFERASE-RXN","compounds":"3'-phosphoadenylyl sulfate + cortisol <=> adenosine 3',5'-bisphosphate + cortisol 21-sulfate + H(+)","pmd":64.82}
{"X":2481,"KEGG":"R02847","RHEA_ID":15920,"DIRECTION":"BI","MASTER_ID":15917,"compounds":"an aldopyranose + NAD(+) <=> aldono-1,5-lactone + H(+) + NADH","pmd":485.061}
{"X":2482,"KEGG":"R02848","RHEA_ID":22743,"DIRECTION":"BI","MASTER_ID":22740,"metacyc":"HEXOKINASE-RXN","compounds":"ATP + D-hexose <=> ADP + D-hexose 6-phosphate + H(+)","pmd":79.966}
{"X":2483,"KEGG":"R02852","RHEA_ID":18244,"DIRECTION":"BI","MASTER_ID":18241,"metacyc":"D-LYSINE-56-AMINOMUTASE-RXN","compounds":"D-lysine <=> (2R,5S)-2,5-diaminohexanoate","pmd":0}
{"X":2484,"KEGG":"R02853","RHEA_ID":24876,"DIRECTION":"BI","MASTER_ID":24873,"compounds":"H2O + O-phospho-D-serine <=> D-serine + phosphate","pmd":79.966}
{"X":2485,"KEGG":"R02857","RHEA_ID":30054,"DIRECTION":"BI","MASTER_ID":30051,"compounds":"fluoroacetate + H2O <=> fluoride + glycolate + H(+)"}
{"X":2486,"KEGG":"R02858","RHEA_ID":17272,"DIRECTION":"BI","MASTER_ID":17269,"compounds":"macrocin + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + tylosin","pmd":14.016}
{"X":2487,"KEGG":"R02859","RHEA_ID":17576,"DIRECTION":"BI","MASTER_ID":17573,"compounds":"demethylmacrocin + S-adenosyl-L-methionine <=> H(+) + macrocin + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":2488,"KEGG":"R02860","RHEA_ID":14772,"DIRECTION":"BI","MASTER_ID":14769,"compounds":"(S)-nicotine + A + H2O <=> (S)-6-hydroxynicotine + AH2","pmd":15.995}
{"X":2489,"KEGG":"R02862","RHEA_ID":16896,"DIRECTION":"BI","MASTER_ID":16893,"metacyc":"PYRIDINE-N-METHYLTRANSFERASE-RXN","compounds":"pyridine + S-adenosyl-L-methionine <=> N-methylpyridinium + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":2490,"KEGG":"R02863","RHEA_ID":17700,"DIRECTION":"BI","MASTER_ID":17697,"metacyc":"THIAMIN-PYRIDINYLASE-RXN","compounds":"pyridine + thiamine <=> 5-(2-hydroxyethyl)-4-methylthiazole + heteropyrithiamine","pmd":63.998}
{"X":2491,"KEGG":"R02864","RHEA_ID":24363,"DIRECTION":"BI","MASTER_ID":24360,"compounds":"2 H(+) + siroheme <=> Fe(2+) + sirohydrochlorin","pmd":53.919}
{"X":2492,"KEGG":"R02866","RHEA_ID":24583,"DIRECTION":"BI","MASTER_ID":24580,"compounds":"D-sorbitol 6-phosphate + H2O <=> D-sorbitol + phosphate","pmd":79.966}
{"X":2493,"KEGG":"R02869","RHEA_ID":19976,"DIRECTION":"BI","MASTER_ID":19973,"compounds":"S-adenosyl 3-(methylsulfanyl)propylamine + spermidine <=> H(+) + S-methyl-5'-thioadenosine + spermine","pmd":57.058}
{"X":2494,"KEGG":"R02869","RHEA_ID":19976,"DIRECTION":"BI","MASTER_ID":19973,"compounds":"S-adenosyl 3-(methylsulfanyl)propylamine + spermidine <=> H(+) + S-methyl-5'-thioadenosine + spermine","pmd":58.066}
{"X":2495,"KEGG":"R02872","RHEA_ID":22235,"DIRECTION":"BI","MASTER_ID":22232,"compounds":"H(+) + NADPH + presqualene diphosphate <=> diphosphate + NADP(+) + squalene","pmd":157.764}
{"X":2496,"KEGG":"R02872","RHEA_ID":22235,"DIRECTION":"BI","MASTER_ID":22232,"compounds":"H(+) + NADPH + presqualene diphosphate <=> diphosphate + NADP(+) + squalene","pmd":334.7}
{"X":2497,"KEGG":"R02872","RHEA_ID":22231,"DIRECTION":"BI","MASTER_ID":22228,"compounds":"H(+) + NADH + presqualene diphosphate <=> diphosphate + NAD(+) + squalene","pmd":157.764}
{"X":2498,"KEGG":"R02872","RHEA_ID":22231,"DIRECTION":"BI","MASTER_ID":22228,"compounds":"H(+) + NADH + presqualene diphosphate <=> diphosphate + NAD(+) + squalene","pmd":334.7}
{"X":2499,"KEGG":"R02873","RHEA_ID":21943,"DIRECTION":"BI","MASTER_ID":21940,"compounds":"AH2 + O2 + squalene <=> (S)-2,3-epoxysqualene + A + H2O"}
{"X":2500,"KEGG":"R02874","RHEA_ID":25285,"DIRECTION":"BI","MASTER_ID":25282,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + squalene <=> (S)-2,3-epoxysqualene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":2501,"KEGG":"R02875","RHEA_ID":30678,"DIRECTION":"BI","MASTER_ID":30675,"compounds":"tetrahymanol <=> H2O + squalene","pmd":18.01}
{"X":2502,"KEGG":"R02877","RHEA_ID":10039,"DIRECTION":"BI","MASTER_ID":10036,"compounds":"4-hydroxy-3-methoxy-benzenemethanol + O2 <=> H2O2 + vanillin","pmd":2.016}
{"X":2503,"KEGG":"R02878","RHEA_ID":24623,"DIRECTION":"BI","MASTER_ID":24620,"metacyc":"OCTANOL-DEHYDROGENASE-RXN","compounds":"NAD(+) + octan-1-ol <=> H(+) + NADH + octanal","pmd":2.016}
{"X":2504,"KEGG":"R02878","RHEA_ID":24623,"DIRECTION":"BI","MASTER_ID":24620,"metacyc":"OCTANOL-DEHYDROGENASE-RXN","compounds":"NAD(+) + octan-1-ol <=> H(+) + NADH + octanal","pmd":535.997}
{"X":2505,"KEGG":"R02879","RHEA_ID":19344,"DIRECTION":"BI","MASTER_ID":19341,"compounds":"2 H(+) + O2 + octane + 2 reduced [rubredoxin] <=> H2O + octan-1-ol + 2 oxidized [rubredoxin]","pmd":15.995}
{"X":2506,"KEGG":"R02880","RHEA_ID":13492,"DIRECTION":"BI","MASTER_ID":13489,"compounds":"(S)-canadine + H(+) + 2 O2 <=> berberine + 2 H2O2","pmd":3.024}
{"X":2507,"KEGG":"R02882","RHEA_ID":11811,"DIRECTION":"BI","MASTER_ID":11808,"compounds":"bergaptol + S-adenosyl-L-methionine <=> bergapten + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":2508,"KEGG":"R02888","RHEA_ID":23027,"DIRECTION":"BI","MASTER_ID":23024,"compounds":"[(1->4)-beta-D-glucosyl](n) + phosphate <=> [(1->4)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate"}
{"X":2509,"KEGG":"R02889","RHEA_ID":19932,"DIRECTION":"BI","MASTER_ID":19929,"metacyc":"CELLULOSE-SYNTHASE-UDP-FORMING-RXN","compounds":"[(1->4)-beta-D-glucosyl](n) + UDP-alpha-D-glucose <=> [(1->4)-beta-D-glucosyl](n+1) + H(+) + UDP","pmd":162.053}
{"X":2510,"KEGG":"R02890","RHEA_ID":17800,"DIRECTION":"BI","MASTER_ID":17797,"compounds":"[(1->4)-beta-D-glucosyl](n) + GDP-alpha-D-glucose <=> [(1->4)-beta-D-glucosyl](n+1) + GDP + H(+)","pmd":162.053}
{"X":2511,"KEGG":"R02892","RHEA_ID":17984,"DIRECTION":"BI","MASTER_ID":17981,"compounds":"4,5alpha-dihydrocortisone + NADP(+) <=> cortisone + H(+) + NADPH","pmd":383.89}
{"X":2512,"KEGG":"R02892","RHEA_ID":17984,"DIRECTION":"BI","MASTER_ID":17981,"compounds":"4,5alpha-dihydrocortisone + NADP(+) <=> cortisone + H(+) + NADPH","pmd":2.016}
{"X":2513,"KEGG":"R02893","RHEA_ID":14040,"DIRECTION":"BI","MASTER_ID":14037,"metacyc":"CORTISONE-BETA-REDUCTASE-RXN","compounds":"4,5beta-dihydrocortisone + NADP(+) <=> cortisone + H(+) + NADPH","pmd":2.016}
{"X":2514,"KEGG":"R02893","RHEA_ID":14040,"DIRECTION":"BI","MASTER_ID":14037,"metacyc":"CORTISONE-BETA-REDUCTASE-RXN","compounds":"4,5beta-dihydrocortisone + NADP(+) <=> cortisone + H(+) + NADPH","pmd":383.89}
{"X":2515,"KEGG":"R02896","RHEA_ID":12728,"DIRECTION":"BI","MASTER_ID":12725,"compounds":"D-iditol + NAD(+) <=> H(+) + keto-D-sorbose + NADH","pmd":2.016}
{"X":2516,"KEGG":"R02896","RHEA_ID":12728,"DIRECTION":"BI","MASTER_ID":12725,"compounds":"D-iditol + NAD(+) <=> H(+) + keto-D-sorbose + NADH","pmd":484.053}
{"X":2517,"KEGG":"R02899","RHEA_ID":23311,"DIRECTION":"BI","MASTER_ID":23308,"compounds":"D-glucarate + sinapoyl-CoA <=> 2-O-sinapoyl-D-glucarate + CoA","pmd":206.058}
{"X":2518,"KEGG":"R02899","RHEA_ID":23311,"DIRECTION":"BI","MASTER_ID":23308,"compounds":"D-glucarate + sinapoyl-CoA <=> 2-O-sinapoyl-D-glucarate + CoA","pmd":557.078}
{"X":2519,"KEGG":"R02901","RHEA_ID":23399,"DIRECTION":"BI","MASTER_ID":23396,"metacyc":"PHLORETIN-HYDROLASE-RXN","compounds":"H2O + phloretin <=> 1,3,5-trihydroxybenzene + H(+) + phloretate","pmd":108.021}
{"X":2520,"KEGG":"R02903","RHEA_ID":23359,"DIRECTION":"BI","MASTER_ID":23356,"metacyc":"2.7.11.14-RXN","compounds":"[rhodopsin]-L-serine + ATP <=> [rhodopsin]-O-phospho-L-serine + ADP + H(+)","pmd":79.966}
{"X":2521,"KEGG":"R02906","RHEA_ID":21911,"DIRECTION":"BI","MASTER_ID":21908,"metacyc":"1.1.1.252-RXN","compounds":"NADP(+) + scytalone <=> H(+) + NADPH + naphthalene-1,3,6,8-tetrol","pmd":2.016}
{"X":2522,"KEGG":"R02906","RHEA_ID":21911,"DIRECTION":"BI","MASTER_ID":21908,"metacyc":"1.1.1.252-RXN","compounds":"NADP(+) + scytalone <=> H(+) + NADPH + naphthalene-1,3,6,8-tetrol","pmd":552.041}
{"X":2523,"KEGG":"R02907","RHEA_ID":24399,"DIRECTION":"BI","MASTER_ID":24396,"metacyc":"SCYTALONE-DEHYDRATASE-RXN","compounds":"scytalone <=> 1,3,8-trihydroxynaphthalene + H2O","pmd":18.011}
{"X":2524,"KEGG":"R02911","RHEA_ID":25220,"DIRECTION":"BI","MASTER_ID":25217,"compounds":"acetyl-CoA + serotonin <=> CoA + H(+) + N-acetylserotonin","pmd":42.011}
{"X":2525,"KEGG":"R02914","RHEA_ID":13104,"DIRECTION":"BI","MASTER_ID":13101,"compounds":"4-imidazolone-5-propanoate <=> H2O + trans-urocanate","pmd":18.011}
{"X":2526,"KEGG":"R02915","RHEA_ID":13536,"DIRECTION":"BI","MASTER_ID":13533,"compounds":"H2O + medicarpin + NADP(+) <=> (3R)-vestitone + H(+) + NADPH","pmd":457.999}
{"X":2527,"KEGG":"R02915","RHEA_ID":13536,"DIRECTION":"BI","MASTER_ID":13533,"compounds":"H2O + medicarpin + NADP(+) <=> (3R)-vestitone + H(+) + NADPH","pmd":15.995}
{"X":2528,"KEGG":"R02917","RHEA_ID":20080,"DIRECTION":"BI","MASTER_ID":20077,"compounds":"guanosine(18) in tRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(18) in tRNA + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":2529,"KEGG":"R02918","RHEA_ID":10223,"DIRECTION":"BI","MASTER_ID":10220,"compounds":"ATP + L-tyrosine + tRNA(Tyr) <=> AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)","pmd":159.933}
{"X":2530,"KEGG":"R02918","RHEA_ID":10223,"DIRECTION":"BI","MASTER_ID":10220,"compounds":"ATP + L-tyrosine + tRNA(Tyr) <=> AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)","pmd":165.989}
{"X":2531,"KEGG":"R02919","RHEA_ID":51171,"DIRECTION":"BI","MASTER_ID":51168,"compounds":"(R)-adrenaline + H2O + O2 <=> 3,4-dihydroxymandelaldehyde + H2O2 + methylamine","pmd":15.047}
{"X":2532,"KEGG":"R02921","RHEA_ID":12459,"DIRECTION":"BI","MASTER_ID":12456,"metacyc":"2.7.7.40-RXN","compounds":"CTP + D-ribitol 5-phosphate + H(+) <=> CDP-L-ribitol + diphosphate","pmd":305.041}
{"X":2533,"KEGG":"R02921","RHEA_ID":12459,"DIRECTION":"BI","MASTER_ID":12456,"metacyc":"2.7.7.40-RXN","compounds":"CTP + D-ribitol 5-phosphate + H(+) <=> CDP-L-ribitol + diphosphate","pmd":54.092}
{"X":2534,"KEGG":"R02922","RHEA_ID":12684,"DIRECTION":"BI","MASTER_ID":12681,"compounds":"creatinine + H(+) + H2O <=> N-methylhydantoin + NH4(+)","pmd":0.984}
{"X":2535,"KEGG":"R02927","RHEA_ID":15516,"DIRECTION":"BI","MASTER_ID":15513,"compounds":"ATP + keto-D-tagatose <=> ADP + H(+) + keto-D-tagatose 6-phosphate","pmd":79.966}
{"X":2536,"KEGG":"R02928","RHEA_ID":20688,"DIRECTION":"BI","MASTER_ID":20685,"compounds":"galactitol + NAD(+) <=> H(+) + keto-D-tagatose + NADH","pmd":484.053}
{"X":2537,"KEGG":"R02928","RHEA_ID":20688,"DIRECTION":"BI","MASTER_ID":20685,"compounds":"galactitol + NAD(+) <=> H(+) + keto-D-tagatose + NADH","pmd":2.016}
{"X":2538,"KEGG":"R02929","RHEA_ID":20528,"DIRECTION":"BI","MASTER_ID":20525,"compounds":"ATP + ethylamine + L-glutamate <=> ADP + H(+) + N(5)-ethyl-L-glutamine + phosphate","pmd":27.047}
{"X":2539,"KEGG":"R02929","RHEA_ID":20528,"DIRECTION":"BI","MASTER_ID":20525,"compounds":"ATP + ethylamine + L-glutamate <=> ADP + H(+) + N(5)-ethyl-L-glutamine + phosphate","pmd":79.966}
{"X":2540,"KEGG":"R02930","RHEA_ID":18016,"DIRECTION":"BI","MASTER_ID":18013,"compounds":"H2O + N(5)-ethyl-L-glutamine <=> ethylamine + L-glutamate","pmd":27.047}
{"X":2541,"KEGG":"R02932","RHEA_ID":56059,"DIRECTION":"BI","MASTER_ID":56056,"compounds":"genistein + UDP-alpha-D-glucose <=> genistein 7-O-beta-D-glucoside + H(+) + UDP","pmd":133.949}
{"X":2542,"KEGG":"R02933","RHEA_ID":42519,"DIRECTION":"BI","MASTER_ID":42516,"compounds":"H2O + L-gulono-1,4-lactone <=> H(+) + L-gulonate","pmd":18.011}
{"X":2543,"KEGG":"R02935","RHEA_ID":15332,"DIRECTION":"BI","MASTER_ID":15329,"compounds":"(S)-ureidoglycolate + NAD(+) <=> H(+) + N-carbamoyl-2-oxoglycine + NADH","pmd":2.016}
{"X":2544,"KEGG":"R02935","RHEA_ID":15332,"DIRECTION":"BI","MASTER_ID":15329,"compounds":"(S)-ureidoglycolate + NAD(+) <=> H(+) + N-carbamoyl-2-oxoglycine + NADH","pmd":532.1}
{"X":2545,"KEGG":"R02936","RHEA_ID":15336,"DIRECTION":"BI","MASTER_ID":15333,"compounds":"(S)-ureidoglycolate + NADP(+) <=> H(+) + N-carbamoyl-2-oxoglycine + NADPH","pmd":612.066}
{"X":2546,"KEGG":"R02936","RHEA_ID":15336,"DIRECTION":"BI","MASTER_ID":15333,"compounds":"(S)-ureidoglycolate + NADP(+) <=> H(+) + N-carbamoyl-2-oxoglycine + NADPH","pmd":2.016}
{"X":2547,"KEGG":"R02937","RHEA_ID":22987,"DIRECTION":"BI","MASTER_ID":22984,"compounds":"carbamoyl phosphate + oxamate <=> N-carbamoyl-2-oxoglycine + phosphate","pmd":8.966}
{"X":2548,"KEGG":"R02938","RHEA_ID":10003,"DIRECTION":"BI","MASTER_ID":10000,"compounds":"H2O + pentanamide <=> NH4(+) + pentanoate","pmd":0.984}
{"X":2549,"KEGG":"R02940","RHEA_ID":30882,"DIRECTION":"BI","MASTER_ID":30879,"compounds":"H2O + NAD(+) + prop-2-ynal <=> 2 H(+) + NADH + propynoate"}
{"X":2550,"KEGG":"R02941","RHEA_ID":18540,"DIRECTION":"BI","MASTER_ID":18537,"compounds":"H2O + NAD(+) + salicylaldehyde <=> 2 H(+) + NADH + salicylate","pmd":15.995}
{"X":2551,"KEGG":"R02941","RHEA_ID":18540,"DIRECTION":"BI","MASTER_ID":18537,"compounds":"H2O + NAD(+) + salicylaldehyde <=> 2 H(+) + NADH + salicylate","pmd":526.085}
{"X":2552,"KEGG":"R02942","RHEA_ID":11755,"DIRECTION":"BI","MASTER_ID":11752,"metacyc":"ACETYLSALICYLATE-DEACETYLASE-RXN","compounds":"acetylsalicylate + H2O <=> acetate + H(+) + salicylate","pmd":42.011}
{"X":2553,"KEGG":"R02944","RHEA_ID":17332,"DIRECTION":"BI","MASTER_ID":17329,"metacyc":"%2b-BORNEOL-DEHYDROGENASE-RXN","compounds":"(1R,2S,4R)-borneol + NAD(+) <=> (1R,4R)-camphor + H(+) + NADH","pmd":511.997}
{"X":2554,"KEGG":"R02944","RHEA_ID":17332,"DIRECTION":"BI","MASTER_ID":17329,"metacyc":"%2b-BORNEOL-DEHYDROGENASE-RXN","compounds":"(1R,2S,4R)-borneol + NAD(+) <=> (1R,4R)-camphor + H(+) + NADH","pmd":2.016}
{"X":2555,"KEGG":"R02945","RHEA_ID":22131,"DIRECTION":"BI","MASTER_ID":22128,"compounds":"(1S,2R,4S)-borneol + NAD(+) <=> (1S,4S)-camphor + H(+) + NADH","pmd":2.016}
{"X":2556,"KEGG":"R02945","RHEA_ID":22131,"DIRECTION":"BI","MASTER_ID":22128,"compounds":"(1S,2R,4S)-borneol + NAD(+) <=> (1S,4S)-camphor + H(+) + NADH","pmd":511.997}
{"X":2557,"KEGG":"R02946","RHEA_ID":24343,"DIRECTION":"BI","MASTER_ID":24340,"metacyc":"RR-BUTANEDIOL-DEHYDROGENASE-RXN","compounds":"(R,R)-butane-2,3-diol + NAD(+) <=> (R)-acetoin + H(+) + NADH"}
{"X":2558,"KEGG":"R02948","RHEA_ID":21583,"DIRECTION":"BI","MASTER_ID":21580,"compounds":"(2S)-2-acetolactate + H(+) <=> (R)-acetoin + CO2"}
{"X":2559,"KEGG":"R02949","RHEA_ID":12095,"DIRECTION":"BI","MASTER_ID":12092,"compounds":"(S)-acetoin <=> (R)-acetoin"}
{"X":2560,"KEGG":"R02951","RHEA_ID":21639,"DIRECTION":"BI","MASTER_ID":21636,"compounds":"trans-4-coumarate + UDP-alpha-D-glucose <=> 4-O-(beta-D-glucosyl)-trans-4-coumarate + H(+) + UDP","pmd":162.053}
{"X":2561,"KEGG":"R02952","RHEA_ID":33230,"DIRECTION":"BI","MASTER_ID":33227,"metacyc":"RXN-802","compounds":"H(+) + trans-4-coumarate <=> 4-hydroxystyrene + CO2","pmd":43.99}
{"X":2562,"KEGG":"R02953","RHEA_ID":22427,"DIRECTION":"BI","MASTER_ID":22424,"metacyc":"S-ALKYLCYSTEINE-LYASE-RXN","compounds":"an S-alkyl-L-cysteine + H2O <=> an alkyl thiol + NH4(+) + pyruvate"}
{"X":2563,"KEGG":"R02954","RHEA_ID":12820,"DIRECTION":"BI","MASTER_ID":12817,"compounds":"2,3-dihydrobiochanin A + NADP(+) <=> biochanin A + 2 H(+) + NADPH","pmd":460.015}
{"X":2564,"KEGG":"R02954","RHEA_ID":12820,"DIRECTION":"BI","MASTER_ID":12817,"compounds":"2,3-dihydrobiochanin A + NADP(+) <=> biochanin A + 2 H(+) + NADPH","pmd":2.016}
{"X":2565,"KEGG":"R02955","RHEA_ID":17624,"DIRECTION":"BI","MASTER_ID":17621,"compounds":"acetyl-CoA + citramalate <=> (3S)-citramalyl-CoA + acetate","pmd":749.105}
{"X":2566,"KEGG":"R02955","RHEA_ID":17624,"DIRECTION":"BI","MASTER_ID":17621,"compounds":"acetyl-CoA + citramalate <=> (3S)-citramalyl-CoA + acetate","pmd":88.016}
{"X":2567,"KEGG":"R02956","RHEA_ID":23531,"DIRECTION":"BI","MASTER_ID":23528,"metacyc":"2.8.3.7-RXN","compounds":"citramalate + succinyl-CoA <=> citramalyl-CoA + succinate"}
{"X":2568,"KEGG":"R02957","RHEA_ID":30886,"DIRECTION":"BI","MASTER_ID":30883,"compounds":"D-glucurono-3,6-lactone + 2 H2O + NAD(+) <=> D-glucarate + 3 H(+) + NADH","pmd":34.005}
{"X":2569,"KEGG":"R02957","RHEA_ID":30886,"DIRECTION":"BI","MASTER_ID":30883,"compounds":"D-glucurono-3,6-lactone + 2 H2O + NAD(+) <=> D-glucarate + 3 H(+) + NADH","pmd":454.079}
{"X":2570,"KEGG":"R02961","RHEA_ID":15200,"DIRECTION":"BI","MASTER_ID":15197,"compounds":"a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine <=> an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":2571,"KEGG":"R02963","RHEA_ID":21059,"DIRECTION":"BI","MASTER_ID":21056,"compounds":"lactoyl-CoA <=> acryloyl-CoA + H2O","pmd":18.01}
{"X":2572,"KEGG":"R02965","RHEA_ID":18644,"DIRECTION":"BI","MASTER_ID":18641,"metacyc":"1.12.5.1-RXN","compounds":"a menaquinone + H2 <=> a menaquinol"}
{"X":2573,"KEGG":"R02965","RHEA_ID":29050,"DIRECTION":"BI","MASTER_ID":29047,"compounds":"a menaquinone + 2 H(+)(in) + H2 <=> a menaquinol + 2 H(+)(out)"}
{"X":2574,"KEGG":"R02968","RHEA_ID":19176,"DIRECTION":"BI","MASTER_ID":19173,"compounds":"H(+) + NADH + naphthalene + O2 <=> (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+)","pmd":503.057}
{"X":2575,"KEGG":"R02968","RHEA_ID":19176,"DIRECTION":"BI","MASTER_ID":19173,"compounds":"H(+) + NADH + naphthalene + O2 <=> (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+)","pmd":34.005}
{"X":2576,"KEGG":"R02969","RHEA_ID":11287,"DIRECTION":"BI","MASTER_ID":11284,"compounds":"hydroxymalonate + NAD(+) <=> H(+) + NADH + oxomalonate","pmd":546.127}
{"X":2577,"KEGG":"R02969","RHEA_ID":11287,"DIRECTION":"BI","MASTER_ID":11284,"compounds":"hydroxymalonate + NAD(+) <=> H(+) + NADH + oxomalonate","pmd":2.016}
{"X":2578,"KEGG":"R02970","RHEA_ID":18812,"DIRECTION":"BI","MASTER_ID":18809,"metacyc":"2.6.1.47-RXN","compounds":"L-alanine + oxomalonate <=> aminomalonate + pyruvate","pmd":1.032}
{"X":2579,"KEGG":"R02971","RHEA_ID":22475,"DIRECTION":"BI","MASTER_ID":22472,"compounds":"(R)-pantetheine + ATP <=> ADP + D-pantetheine 4'-phosphate + H(+)","pmd":79.966}
{"X":2580,"KEGG":"R02972","RHEA_ID":15080,"DIRECTION":"BI","MASTER_ID":15077,"compounds":"H(+) + N-[(R)-pantothenoyl]-L-cysteine <=> (R)-pantetheine + CO2","pmd":43.99}
{"X":2581,"KEGG":"R02973","RHEA_ID":13448,"DIRECTION":"BI","MASTER_ID":13445,"metacyc":"3.5.1.92-RXN","compounds":"(R)-pantetheine + H2O <=> (R)-pantothenate + cysteamine","pmd":59.019}
{"X":2582,"KEGG":"R02974","RHEA_ID":14028,"DIRECTION":"BI","MASTER_ID":14025,"compounds":"H(+) + H2O + sepiapterin <=> NH4(+) + xanthopterin-B2","pmd":0.984}
{"X":2583,"KEGG":"R02975","RHEA_ID":18956,"DIRECTION":"BI","MASTER_ID":18953,"metacyc":"SEPIAPTERIN-REDUCTASE-RXN","compounds":"L-erythro-7,8-dihydrobiopterin + NADP(+) <=> H(+) + NADPH + sepiapterin","pmd":2.016}
{"X":2584,"KEGG":"R02975","RHEA_ID":18956,"DIRECTION":"BI","MASTER_ID":18953,"metacyc":"SEPIAPTERIN-REDUCTASE-RXN","compounds":"L-erythro-7,8-dihydrobiopterin + NADP(+) <=> H(+) + NADPH + sepiapterin","pmd":506.997}
{"X":2585,"KEGG":"R02976","RHEA_ID":15468,"DIRECTION":"BI","MASTER_ID":15465,"compounds":"ATP + sphinganine <=> ADP + H(+) + sphinganine 1-phosphate","pmd":79.966}
{"X":2586,"KEGG":"R02978","RHEA_ID":22643,"DIRECTION":"BI","MASTER_ID":22640,"metacyc":"RXN-12642","compounds":"NADP(+) + sphinganine <=> 3-oxosphinganine + H(+) + NADPH","pmd":2.016}
{"X":2587,"KEGG":"R02978","RHEA_ID":22643,"DIRECTION":"BI","MASTER_ID":22640,"metacyc":"RXN-12642","compounds":"NADP(+) + sphinganine <=> 3-oxosphinganine + H(+) + NADPH","pmd":444.801}
{"X":2588,"KEGG":"R02982","RHEA_ID":21247,"DIRECTION":"BI","MASTER_ID":21244,"compounds":"an 8-hydroxyfurocoumarin + S-adenosyl-L-methionine <=> an 8-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":2589,"KEGG":"R02982","RHEA_ID":17904,"DIRECTION":"BI","MASTER_ID":17901,"compounds":"S-adenosyl-L-methionine + xanthotoxol <=> H(+) + S-adenosyl-L-homocysteine + xanthotoxin","pmd":14.016}
{"X":2590,"KEGG":"R02985","RHEA_ID":14180,"DIRECTION":"BI","MASTER_ID":14177,"compounds":"(R)-amygdalin + H2O <=> (R)-prunasin + D-glucose","pmd":162.053}
{"X":2591,"KEGG":"R02985","RHEA_ID":14180,"DIRECTION":"BI","MASTER_ID":14177,"compounds":"(R)-amygdalin + H2O <=> (R)-prunasin + D-glucose","pmd":277.095}
{"X":2592,"KEGG":"R02986","RHEA_ID":19272,"DIRECTION":"BI","MASTER_ID":19269,"compounds":"2-furoate + ATP + CoA <=> 2-furoyl-CoA + AMP + diphosphate","pmd":235.047}
{"X":2593,"KEGG":"R02986","RHEA_ID":19272,"DIRECTION":"BI","MASTER_ID":19269,"compounds":"2-furoate + ATP + CoA <=> 2-furoyl-CoA + AMP + diphosphate","pmd":159.933}
{"X":2594,"KEGG":"R02986","RHEA_ID":19272,"DIRECTION":"BI","MASTER_ID":19269,"compounds":"2-furoate + ATP + CoA <=> 2-furoyl-CoA + AMP + diphosphate","pmd":94.006}
{"X":2595,"KEGG":"R02987","RHEA_ID":21483,"DIRECTION":"BI","MASTER_ID":21480,"compounds":"2-furoyl-CoA + A + H2O <=> 5-hydroxy-2-furoyl-CoA + AH2 + H(+)","pmd":15.995}
{"X":2596,"KEGG":"R02988","RHEA_ID":16984,"DIRECTION":"BI","MASTER_ID":16981,"compounds":"3-oxoadipate + NAD(+) <=> H(+) + maleylacetate + NADH","pmd":2.016}
{"X":2597,"KEGG":"R02988","RHEA_ID":16984,"DIRECTION":"BI","MASTER_ID":16981,"compounds":"3-oxoadipate + NAD(+) <=> H(+) + maleylacetate + NADH","pmd":506.095}
{"X":2598,"KEGG":"R02989","RHEA_ID":16988,"DIRECTION":"BI","MASTER_ID":16985,"compounds":"3-oxoadipate + NADP(+) <=> H(+) + maleylacetate + NADPH","pmd":586.062}
{"X":2599,"KEGG":"R02989","RHEA_ID":16988,"DIRECTION":"BI","MASTER_ID":16985,"compounds":"3-oxoadipate + NADP(+) <=> H(+) + maleylacetate + NADPH","pmd":2.016}
{"X":2600,"KEGG":"R02990","RHEA_ID":12051,"DIRECTION":"BI","MASTER_ID":12048,"compounds":"3-oxoadipate + succinyl-CoA <=> 3-oxoadipyl-CoA + succinate","pmd":42.011}
{"X":2601,"KEGG":"R02990","RHEA_ID":12051,"DIRECTION":"BI","MASTER_ID":12048,"compounds":"3-oxoadipate + succinyl-CoA <=> 3-oxoadipyl-CoA + succinate","pmd":42.01}
{"X":2602,"KEGG":"R02991","RHEA_ID":10187,"DIRECTION":"BI","MASTER_ID":10184,"compounds":"(4,5-dihydro-5-oxofuran-2-yl)-acetate + H2O <=> 3-oxoadipate + H(+)","pmd":18.011}
{"X":2603,"KEGG":"R02992","RHEA_ID":14304,"DIRECTION":"BI","MASTER_ID":14301,"compounds":"4-pyridoxolactone + H2O <=> 4-pyridoxate + H(+)","pmd":18.011}
{"X":2604,"KEGG":"R02994","RHEA_ID":11739,"DIRECTION":"BI","MASTER_ID":11736,"compounds":"2-exo-hydroxy-1,8-cineole + NAD(+) <=> 6-oxocineole + H(+) + NADH","pmd":496.002}
{"X":2605,"KEGG":"R02994","RHEA_ID":11739,"DIRECTION":"BI","MASTER_ID":11736,"compounds":"2-exo-hydroxy-1,8-cineole + NAD(+) <=> 6-oxocineole + H(+) + NADH","pmd":2.016}
{"X":2606,"KEGG":"R02995","RHEA_ID":24327,"DIRECTION":"BI","MASTER_ID":24324,"compounds":"6-oxocineole + H(+) + NADPH + O2 <=> 1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + H2O + NADP(+)","pmd":560.981}
{"X":2607,"KEGG":"R02995","RHEA_ID":24327,"DIRECTION":"BI","MASTER_ID":24324,"compounds":"6-oxocineole + H(+) + NADPH + O2 <=> 1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + H2O + NADP(+)","pmd":15.995}
{"X":2608,"KEGG":"R02996","RHEA_ID":51075,"DIRECTION":"BI","MASTER_ID":51072,"metacyc":"ARYLSULFATE-SULFOTRANSFERASE-RXN","compounds":"a phenol + a phenyl sulfate <=> a phenol + a phenyl sulfate","pmd":0}
{"X":2609,"KEGG":"R02997","RHEA_ID":20692,"DIRECTION":"BI","MASTER_ID":20689,"compounds":"chlorogenate + H2O <=> (E)-caffeate + H(+) + L-quinate","pmd":162.032}
{"X":2610,"KEGG":"R02998","RHEA_ID":23207,"DIRECTION":"BI","MASTER_ID":23204,"compounds":"chlorogenate + D-glucarate <=> 2-O-caffeoylglucarate + L-quinate","pmd":17.974}
{"X":2611,"KEGG":"R02999","RHEA_ID":16116,"DIRECTION":"BI","MASTER_ID":16113,"compounds":"2 [cyanocobalamin reductase]-cob(II)alamin + 2 hydrogen cyanide + NADP(+) <=> 2 apo--[cyanocobalamin reductase] + 2 cyanocob(III)alamin + H(+) + NADPH"}
{"X":2612,"KEGG":"R03001","RHEA_ID":23839,"DIRECTION":"BI","MASTER_ID":23836,"metacyc":"2.6.1.41-RXN","compounds":"D-methionine + pyruvate <=> 4-methylsulfanyl-2-oxobutanoate + L-alanine","pmd":1.032}
{"X":2613,"KEGG":"R03003","RHEA_ID":16860,"DIRECTION":"BI","MASTER_ID":16857,"compounds":"a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine <=> an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":2614,"KEGG":"R03005","RHEA_ID":22863,"DIRECTION":"BI","MASTER_ID":22860,"compounds":"ATP + H(+) + nicotinate beta-D-ribonucleotide <=> deamido-NAD(+) + diphosphate","pmd":329.053}
{"X":2615,"KEGG":"R03005","RHEA_ID":22863,"DIRECTION":"BI","MASTER_ID":22860,"compounds":"ATP + H(+) + nicotinate beta-D-ribonucleotide <=> deamido-NAD(+) + diphosphate","pmd":158.105}
{"X":2616,"KEGG":"R03006","RHEA_ID":22963,"DIRECTION":"BI","MASTER_ID":22960,"compounds":"formononetin + O2 + reduced [NADPH--hemoprotein reductase] <=> calycosin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":2617,"KEGG":"R03008","RHEA_ID":15008,"DIRECTION":"BI","MASTER_ID":15005,"compounds":"2-oxoglutarate + gibberellin A1 + O2 <=> CO2 + gibberellin A8 + succinate","pmd":27.995}
{"X":2618,"KEGG":"R03008","RHEA_ID":15008,"DIRECTION":"BI","MASTER_ID":15005,"compounds":"2-oxoglutarate + gibberellin A1 + O2 <=> CO2 + gibberellin A8 + succinate","pmd":15.995}
{"X":2619,"KEGG":"R03009","RHEA_ID":10107,"DIRECTION":"BI","MASTER_ID":10104,"compounds":"2-oxoglutarate + gibberellin A20 + O2 <=> CO2 + gibberellin A1 + succinate","pmd":15.995}
{"X":2620,"KEGG":"R03009","RHEA_ID":10107,"DIRECTION":"BI","MASTER_ID":10104,"compounds":"2-oxoglutarate + gibberellin A20 + O2 <=> CO2 + gibberellin A1 + succinate","pmd":27.995}
{"X":2621,"KEGG":"R03012","RHEA_ID":33802,"DIRECTION":"BI","MASTER_ID":33799,"compounds":"L-histidinol + NAD(+) <=> H(+) + L-histidinal + NADH","pmd":2.016}
{"X":2622,"KEGG":"R03012","RHEA_ID":33802,"DIRECTION":"BI","MASTER_ID":33799,"compounds":"L-histidinol + NAD(+) <=> H(+) + L-histidinal + NADH","pmd":525.042}
{"X":2623,"KEGG":"R03013","RHEA_ID":14468,"DIRECTION":"BI","MASTER_ID":14465,"compounds":"H2O + L-histidinol phosphate <=> L-histidinol + phosphate","pmd":79.966}
{"X":2624,"KEGG":"R03014","RHEA_ID":20120,"DIRECTION":"BI","MASTER_ID":20117,"compounds":"ATP + L-rhamnulose <=> ADP + H(+) + L-rhamnulose 1-phosphate","pmd":79.966}
{"X":2625,"KEGG":"R03015","RHEA_ID":19844,"DIRECTION":"BI","MASTER_ID":19841,"metacyc":"FORMYLMETHANOFURAN-DEHYDROGENASE-RXN","compounds":"H2O + N-formylmethanofuran + 2 oxidized [2Fe-2S]-[ferredoxin] <=> CO2 + H(+) + methanofuran + 2 reduced [2Fe-2S]-[ferredoxin]","pmd":27.995}
{"X":2626,"KEGG":"R03018","RHEA_ID":16376,"DIRECTION":"BI","MASTER_ID":16373,"compounds":"(R)-pantothenate + ATP <=> (R)-4'-phosphopantothenate + ADP + H(+)","pmd":79.966}
{"X":2627,"KEGG":"R03019","RHEA_ID":62435,"DIRECTION":"BI","MASTER_ID":62432,"compounds":"a uridine in tRNA + S-adenosyl-L-methionine <=> a 3-[(3S)-3-amino-3-carboxypropyl]-uridine in tRNA + H(+) + S-methyl-5'-thioadenosine","pmd":101.048}
{"X":2628,"KEGG":"R03020","RHEA_ID":54575,"DIRECTION":"BI","MASTER_ID":54572,"compounds":"a uridine in tRNA <=> a pseudouridine in tRNA"}
{"X":2629,"KEGG":"R03021","RHEA_ID":15952,"DIRECTION":"BI","MASTER_ID":15949,"compounds":"(R)-2-hydroxyoctadecanoate + NAD(+) <=> 2-oxodecanoate + H(+) + NADH","pmd":365.866}
{"X":2630,"KEGG":"R03021","RHEA_ID":15952,"DIRECTION":"BI","MASTER_ID":15949,"compounds":"(R)-2-hydroxyoctadecanoate + NAD(+) <=> 2-oxodecanoate + H(+) + NADH","pmd":2.016}
{"X":2631,"KEGG":"R03022","RHEA_ID":11387,"DIRECTION":"BI","MASTER_ID":11384,"compounds":"(S)-2-hydroxydecanoate + NAD(+) <=> 2-oxodecanoate + H(+) + NADH","pmd":2.016}
{"X":2632,"KEGG":"R03022","RHEA_ID":11387,"DIRECTION":"BI","MASTER_ID":11384,"compounds":"(S)-2-hydroxydecanoate + NAD(+) <=> 2-oxodecanoate + H(+) + NADH","pmd":365.866}
{"X":2633,"KEGG":"R03023","RHEA_ID":12571,"DIRECTION":"BI","MASTER_ID":12568,"compounds":"4-nitrophenol + H(+) + NADH + O2 <=> 4-nitrocatechol + H2O + NAD(+)","pmd":510.103}
{"X":2634,"KEGG":"R03023","RHEA_ID":12571,"DIRECTION":"BI","MASTER_ID":12568,"compounds":"4-nitrophenol + H(+) + NADH + O2 <=> 4-nitrocatechol + H2O + NAD(+)","pmd":15.995}
{"X":2635,"KEGG":"R03024","RHEA_ID":21667,"DIRECTION":"BI","MASTER_ID":21664,"compounds":"4-nitrophenyl phosphate + H2O <=> 4-nitrophenol + H(+) + phosphate","pmd":79.966}
{"X":2636,"KEGG":"R03025","RHEA_ID":23763,"DIRECTION":"BI","MASTER_ID":23760,"compounds":"H(+) + H2 + oxidized coenzyme F420-(gamma-Glu)(n) <=> reduced coenzyme F420-(gamma-Glu)(n)","pmd":2.016}
{"X":2637,"KEGG":"R03026","RHEA_ID":26561,"DIRECTION":"BI","MASTER_ID":26558,"metacyc":"RXN-11667","compounds":"(3S)-hydroxybutanoyl-CoA <=> (2E)-butenoyl-CoA + H2O","pmd":18.011}
{"X":2638,"KEGG":"R03027","RHEA_ID":17852,"DIRECTION":"BI","MASTER_ID":17849,"ecocyc":"3-HYDROXBUTYRYL-COA-DEHYDRATASE-RXN","metacyc":"3-HYDROXBUTYRYL-COA-DEHYDRATASE-RXN","compounds":"(3R)-hydroxybutanoyl-CoA <=> (2E)-butenoyl-CoA + H2O","pmd":18.011}
{"X":2639,"KEGG":"R03028","RHEA_ID":23975,"DIRECTION":"BI","MASTER_ID":23972,"compounds":"(2E)-glutaconyl-CoA + H(+) + Na(+)(in) <=> (2E)-butenoyl-CoA + CO2 + Na(+)(out)","pmd":43.99}
{"X":2640,"KEGG":"R03030","RHEA_ID":10059,"DIRECTION":"BI","MASTER_ID":10056,"metacyc":"4.3.1.14-RXN","compounds":"(3S)-3-aminobutanoyl-CoA <=> (2E)-butenoyl-CoA + NH4(+)","pmd":17.027}
{"X":2641,"KEGG":"R03031","RHEA_ID":10575,"DIRECTION":"BI","MASTER_ID":10572,"metacyc":"VINYLACETYL-COA-DELTA-ISOMERASE-RXN","compounds":"vinylacetyl-CoA <=> (2E)-butenoyl-CoA","pmd":0}
{"X":2642,"KEGG":"R03032","RHEA_ID":21839,"DIRECTION":"BI","MASTER_ID":21836,"compounds":"D-arabinonate <=> 2-dehydro-3-deoxy-D-arabinonate + H2O","pmd":18.01}
{"X":2643,"KEGG":"R03033","RHEA_ID":18652,"DIRECTION":"BI","MASTER_ID":18649,"compounds":"D-galactonate <=> 2-dehydro-3-deoxy-D-galactonate + H2O","pmd":18.011}
{"X":2644,"KEGG":"R03034","RHEA_ID":44903,"DIRECTION":"BI","MASTER_ID":44900,"compounds":"D-galactono-1,4-lactone + H2O <=> D-galactonate + H(+)","pmd":18.011}
{"X":2645,"KEGG":"R03035","RHEA_ID":19804,"DIRECTION":"BI","MASTER_ID":19801,"compounds":"ATP + D-pantetheine 4'-phosphate + H(+) <=> 3'-dephospho-CoA + diphosphate","pmd":180.153}
{"X":2646,"KEGG":"R03035","RHEA_ID":19804,"DIRECTION":"BI","MASTER_ID":19801,"compounds":"ATP + D-pantetheine 4'-phosphate + H(+) <=> 3'-dephospho-CoA + diphosphate","pmd":329.053}
{"X":2647,"KEGG":"R03037","RHEA_ID":11115,"DIRECTION":"BI","MASTER_ID":11112,"ecocyc":"ISOCHORMAT-RXN","metacyc":"ISOCHORMAT-RXN","compounds":"H2O + isochorismate <=> (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate","pmd":70.005}
{"X":2648,"KEGG":"R03038","RHEA_ID":12543,"DIRECTION":"BI","MASTER_ID":12540,"compounds":"ATP + L-alanine + tRNA(Ala) <=> AMP + diphosphate + L-alanyl-tRNA(Ala)","pmd":159.933}
{"X":2649,"KEGG":"R03039","RHEA_ID":20492,"DIRECTION":"BI","MASTER_ID":20489,"compounds":"1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-alanyl-tRNA(Ala) <=> 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-alanyl)-sn-glycerol + tRNA(Ala)"}
{"X":2650,"KEGG":"R03040","RHEA_ID":14460,"DIRECTION":"BI","MASTER_ID":14457,"compounds":"glyoxylate + H2O + pentanoyl-CoA <=> 3-propylmalate + CoA + H(+)","pmd":675.104}
{"X":2651,"KEGG":"R03040","RHEA_ID":14460,"DIRECTION":"BI","MASTER_ID":14457,"compounds":"glyoxylate + H2O + pentanoyl-CoA <=> 3-propylmalate + CoA + H(+)","pmd":84.058}
{"X":2652,"KEGG":"R03042","RHEA_ID":21531,"DIRECTION":"BI","MASTER_ID":21528,"compounds":"[phosphate](n) + H2O <=> [phosphate](n-1) + H(+) + phosphate"}
{"X":2653,"KEGG":"R03043","RHEA_ID":11451,"DIRECTION":"BI","MASTER_ID":11448,"compounds":"NAD(+) + pregnan-21-ol <=> H(+) + NADH + pregnan-21-al","pmd":2.016}
{"X":2654,"KEGG":"R03043","RHEA_ID":11451,"DIRECTION":"BI","MASTER_ID":11448,"compounds":"NAD(+) + pregnan-21-ol <=> H(+) + NADH + pregnan-21-al","pmd":361.856}
{"X":2655,"KEGG":"R03044","RHEA_ID":23715,"DIRECTION":"BI","MASTER_ID":23712,"compounds":"NADP(+) + pregnan-21-ol <=> H(+) + NADPH + pregnan-21-al","pmd":440.815}
{"X":2656,"KEGG":"R03044","RHEA_ID":23715,"DIRECTION":"BI","MASTER_ID":23712,"compounds":"NADP(+) + pregnan-21-ol <=> H(+) + NADPH + pregnan-21-al","pmd":2.016}
{"X":2657,"KEGG":"R03045","RHEA_ID":26521,"DIRECTION":"BI","MASTER_ID":26518,"compounds":"3-hydroxypropanoyl-CoA <=> acryloyl-CoA + H2O","pmd":18.01}
{"X":2658,"KEGG":"R03046","RHEA_ID":12419,"DIRECTION":"BI","MASTER_ID":12416,"metacyc":"BETA-ALANYL-COA-AMMONIA-LYASE-RXN","compounds":"beta-alanyl-CoA <=> acryloyl-CoA + NH4(+)","pmd":17.026}
{"X":2659,"KEGG":"R03048","RHEA_ID":42063,"DIRECTION":"BI","MASTER_ID":42060,"compounds":"11-cis-retinol + NAD(+) <=> 11-cis-retinal + H(+) + NADH","pmd":2.016}
{"X":2660,"KEGG":"R03048","RHEA_ID":42063,"DIRECTION":"BI","MASTER_ID":42060,"compounds":"11-cis-retinol + NAD(+) <=> 11-cis-retinal + H(+) + NADH","pmd":379.903}
{"X":2661,"KEGG":"R03049","RHEA_ID":19700,"DIRECTION":"BI","MASTER_ID":19697,"compounds":"11-cis-retinyl hexadecanoate + H2O <=> 11-cis-retinol + H(+) + hexadecanoate","pmd":238.23}
{"X":2662,"KEGG":"R03052","RHEA_ID":16364,"DIRECTION":"BI","MASTER_ID":16361,"metacyc":"2-ACETOLACTATE-MUTASE-RXN","compounds":"2-acetolactate <=> 3-hydroxy-3-methyl-2-oxobutanoate","pmd":0}
{"X":2663,"KEGG":"R03053","RHEA_ID":23603,"DIRECTION":"BI","MASTER_ID":23600,"metacyc":"2-AMINOHEXANOATE-AMINOTRANSFERASE-RXN","compounds":"2-oxoglutarate + L-2-aminohexanoate <=> 2-oxohexanoate + L-glutamate","pmd":1.032}
{"X":2664,"KEGG":"R03054","RHEA_ID":10395,"DIRECTION":"BI","MASTER_ID":10392,"metacyc":"CINNAMYL-ALCOHOL-DEHYDROGENASE-RXN","compounds":"(E)-cinnamyl alcohol + NADP(+) <=> (E)-cinnamaldehyde + H(+) + NADPH","pmd":611.018}
{"X":2665,"KEGG":"R03054","RHEA_ID":10395,"DIRECTION":"BI","MASTER_ID":10392,"metacyc":"CINNAMYL-ALCOHOL-DEHYDROGENASE-RXN","compounds":"(E)-cinnamyl alcohol + NADP(+) <=> (E)-cinnamaldehyde + H(+) + NADPH","pmd":2.016}
{"X":2666,"KEGG":"R03056","RHEA_ID":24519,"DIRECTION":"BI","MASTER_ID":24516,"metacyc":"GENTAMICIN-2-N-ACETYLTRANSFERASE-RXN","compounds":"acetyl-CoA + gentamicin C1a <=> CoA + H(+) + N(2')-acetylgentamicin C1a","pmd":42.011}
{"X":2667,"KEGG":"R03058","RHEA_ID":17964,"DIRECTION":"BI","MASTER_ID":17961,"compounds":"(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate <=> H2O + leukotriene A4","pmd":18.011}
{"X":2668,"KEGG":"R03059","RHEA_ID":17620,"DIRECTION":"BI","MASTER_ID":17617,"compounds":"leukotriene C4 <=> glutathione + leukotriene A4","pmd":307.084}
{"X":2669,"KEGG":"R03059","RHEA_ID":17620,"DIRECTION":"BI","MASTER_ID":17617,"compounds":"leukotriene C4 <=> glutathione + leukotriene A4","pmd":318.22}
{"X":2670,"KEGG":"R03060","RHEA_ID":10147,"DIRECTION":"BI","MASTER_ID":10144,"compounds":"a ribonucleoside 3'-phosphate + H2O <=> a ribonucleoside + phosphate"}
{"X":2671,"KEGG":"R03062","RHEA_ID":22599,"DIRECTION":"BI","MASTER_ID":22596,"compounds":"cephalosporin C + H2O <=> acetate + deacetylcephalosporin C + H(+)","pmd":42.01}
{"X":2672,"KEGG":"R03063","RHEA_ID":14556,"DIRECTION":"BI","MASTER_ID":14553,"metacyc":"CEPHALOSPORIN-C-TRANSAMINASE-RXN","compounds":"(7R)-7-(5-carboxy-5-oxopentanamido)deacetylcephalosporanate + D-glutamate <=> 2-oxoglutarate + cephalosporin C","pmd":1.032}
{"X":2673,"KEGG":"R03064","RHEA_ID":23863,"DIRECTION":"BI","MASTER_ID":23860,"compounds":"acetyl-CoA + deacetylcephalosporin C <=> cephalosporin C + CoA","pmd":42.011}
{"X":2674,"KEGG":"R03064","RHEA_ID":23863,"DIRECTION":"BI","MASTER_ID":23860,"compounds":"acetyl-CoA + deacetylcephalosporin C <=> cephalosporin C + CoA","pmd":42.01}
{"X":2675,"KEGG":"R03065","RHEA_ID":18424,"DIRECTION":"BI","MASTER_ID":18421,"metacyc":"CHLORAMPHENICOL-O-ACETYLTRANSFERASE-RXN","compounds":"acetyl-CoA + chloramphenicol <=> chloramphenicol 3-acetate + CoA","pmd":42.011}
{"X":2676,"KEGG":"R03066","RHEA_ID":30890,"DIRECTION":"BI","MASTER_ID":30887,"compounds":"4-aminobenzoate + 6-hydroxymethyl-7,8-dihydropterin <=> 7,8-dihydropteroate + H2O","pmd":119.037}
{"X":2677,"KEGG":"R03066","RHEA_ID":30890,"DIRECTION":"BI","MASTER_ID":30887,"compounds":"4-aminobenzoate + 6-hydroxymethyl-7,8-dihydropterin <=> 7,8-dihydropteroate + H2O","pmd":177.065}
{"X":2678,"KEGG":"R03067","RHEA_ID":19952,"DIRECTION":"BI","MASTER_ID":19949,"compounds":"(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate <=> 7,8-dihydropteroate + diphosphate","pmd":40.896}
{"X":2679,"KEGG":"R03067","RHEA_ID":19952,"DIRECTION":"BI","MASTER_ID":19949,"compounds":"(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate <=> 7,8-dihydropteroate + diphosphate","pmd":177.065}
{"X":2680,"KEGG":"R03069","RHEA_ID":20256,"DIRECTION":"BI","MASTER_ID":20253,"metacyc":"DIMETHYLMALEATE-HYDRATASE-RXN","compounds":"(2R,3S)-2,3-dimethylmalate <=> dimethylmaleate + H2O","pmd":18.01}
{"X":2681,"KEGG":"R03070","RHEA_ID":23483,"DIRECTION":"BI","MASTER_ID":23480,"compounds":"2-methylene-3-methylsuccinate <=> dimethylmaleate","pmd":0}
{"X":2682,"KEGG":"R03071","RHEA_ID":12912,"DIRECTION":"BI","MASTER_ID":12909,"compounds":"2 [Fe(II)cytochrome] + 2 H(+) + nitrate <=> 2 [Fe(III)cytochrome] + H2O + nitrite"}
{"X":2683,"KEGG":"R03072","RHEA_ID":19848,"DIRECTION":"BI","MASTER_ID":19845,"metacyc":"ISONOCARDICIN-SYNTHASE-RXN","compounds":"nocardicin E + S-adenosyl-L-methionine <=> H(+) + isonocardicin A + S-methyl-5'-thioadenosine","pmd":101.048}
{"X":2684,"KEGG":"R03073","RHEA_ID":22795,"DIRECTION":"BI","MASTER_ID":22792,"metacyc":"NOCARDICIN-A-EPIMERASE-RXN","compounds":"isonocardicin A <=> nocardicin A","pmd":0}
{"X":2685,"KEGG":"R03075","RHEA_ID":12027,"DIRECTION":"BI","MASTER_ID":12024,"compounds":"1-O-(trans-sinapoyl)-beta-D-glucose + choline <=> D-glucose + O-sinapoylcholine","pmd":75.956}
{"X":2686,"KEGG":"R03080","RHEA_ID":23875,"DIRECTION":"BI","MASTER_ID":23872,"compounds":"(R)-propane-1,2-diol + NAD(+) <=> (R)-lactaldehyde + H(+) + NADH"}
{"X":2687,"KEGG":"R03083","RHEA_ID":21971,"DIRECTION":"BI","MASTER_ID":21968,"compounds":"7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate <=> 3-dehydroquinate + phosphate","pmd":97.977}
{"X":2688,"KEGG":"R03084","RHEA_ID":21099,"DIRECTION":"BI","MASTER_ID":21096,"ecocyc":"3-DEHYDROQUINATE-DEHYDRATASE-RXN","metacyc":"3-DEHYDROQUINATE-DEHYDRATASE-RXN","compounds":"3-dehydroquinate <=> 3-dehydroshikimate + H2O","pmd":18.01}
{"X":2689,"KEGG":"R03086","RHEA_ID":19140,"DIRECTION":"BI","MASTER_ID":19137,"compounds":"17beta-estradiol + AH2 + O2 <=> 6beta-hydroxyestradiol-17beta + A + H2O","pmd":15.995}
{"X":2690,"KEGG":"R03087","RHEA_ID":38190,"DIRECTION":"BI","MASTER_ID":38187,"compounds":"19-oxotestosterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 17beta-estradiol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":30.011}
{"X":2691,"KEGG":"R03093","RHEA_ID":45779,"DIRECTION":"BI","MASTER_ID":45776,"compounds":"(indol-3-yl)acetonitrile + 2 H2O <=> (indol-3-yl)acetate + NH4(+)","pmd":18.995}
{"X":2692,"KEGG":"R03094","RHEA_ID":14924,"DIRECTION":"BI","MASTER_ID":14921,"compounds":"(indol-3-yl)acetate + UDP-alpha-D-glucose <=> 1-O-(indol-3-ylacetyl)-beta-D-glucose + UDP","pmd":162.053}
{"X":2693,"KEGG":"R03095","RHEA_ID":14860,"DIRECTION":"BI","MASTER_ID":14857,"compounds":"(indol-3-yl)acetate + ATP + L-lysine <=> ADP + H(+) + N(6)-[(indole-3-yl)acetyl]-L-lysine + phosphate","pmd":157.053}
{"X":2694,"KEGG":"R03095","RHEA_ID":14860,"DIRECTION":"BI","MASTER_ID":14857,"compounds":"(indol-3-yl)acetate + ATP + L-lysine <=> ADP + H(+) + N(6)-[(indole-3-yl)acetyl]-L-lysine + phosphate","pmd":79.966}
{"X":2695,"KEGG":"R03095","RHEA_ID":14860,"DIRECTION":"BI","MASTER_ID":14857,"compounds":"(indol-3-yl)acetate + ATP + L-lysine <=> ADP + H(+) + N(6)-[(indole-3-yl)acetyl]-L-lysine + phosphate","pmd":128.095}
{"X":2696,"KEGG":"R03096","RHEA_ID":34374,"DIRECTION":"BI","MASTER_ID":34371,"compounds":"H2O + indole-3-acetamide <=> (indol-3-yl)acetate + NH4(+)","pmd":0.984}
{"X":2697,"KEGG":"R03102","RHEA_ID":12311,"DIRECTION":"BI","MASTER_ID":12308,"metacyc":"ALLYSINE-DEHYDROG-RXN","compounds":"(S)-2-amino-6-oxohexanoate + H2O + NAD(+) <=> 2 H(+) + L-2-aminoadipate + NADH","pmd":15.995}
{"X":2698,"KEGG":"R03102","RHEA_ID":12311,"DIRECTION":"BI","MASTER_ID":12308,"metacyc":"ALLYSINE-DEHYDROG-RXN","compounds":"(S)-2-amino-6-oxohexanoate + H2O + NAD(+) <=> 2 H(+) + L-2-aminoadipate + NADH","pmd":503.048}
{"X":2699,"KEGG":"R03103","RHEA_ID":12307,"DIRECTION":"BI","MASTER_ID":12304,"compounds":"(S)-2-amino-6-oxohexanoate + H2O + NADP(+) <=> 2 H(+) + L-2-aminoadipate + NADPH","pmd":583.014}
{"X":2700,"KEGG":"R03103","RHEA_ID":12307,"DIRECTION":"BI","MASTER_ID":12304,"compounds":"(S)-2-amino-6-oxohexanoate + H2O + NADP(+) <=> 2 H(+) + L-2-aminoadipate + NADPH","pmd":15.995}
{"X":2701,"KEGG":"R03105","RHEA_ID":21743,"DIRECTION":"BI","MASTER_ID":21740,"compounds":"3-mercaptopyruvate + [thioredoxin]-dithiol <=> [thioredoxin]-disulfide + H(+) + hydrogen sulfide + pyruvate"}
{"X":2702,"KEGG":"R03109","RHEA_ID":10347,"DIRECTION":"BI","MASTER_ID":10344,"metacyc":"PLASMALOGEN-SYNTHASE-RXN","compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA"}
{"X":2703,"KEGG":"R03109","RHEA_ID":10347,"DIRECTION":"BI","MASTER_ID":10344,"metacyc":"2.3.1.104-RXN","compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA"}
{"X":2704,"KEGG":"R03110","RHEA_ID":21075,"DIRECTION":"BI","MASTER_ID":21072,"compounds":"1-O-(1Z)-alkenyl-2-acylglycerol + CDP-choline <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)","pmd":165.055}
{"X":2705,"KEGG":"R03110","RHEA_ID":36230,"DIRECTION":"BI","MASTER_ID":36227,"compounds":"1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-choline <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)","pmd":165.055}
{"X":2706,"KEGG":"R03111","RHEA_ID":15564,"DIRECTION":"BI","MASTER_ID":15561,"compounds":"S-adenosyl-L-methionine + sterigmatocystin <=> 8-O-methylsterigmatocystin + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":2707,"KEGG":"R03112","RHEA_ID":11507,"DIRECTION":"BI","MASTER_ID":11504,"compounds":"6-demethylsterigmatocystin + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + sterigmatocystin","pmd":14.016}
{"X":2708,"KEGG":"R03114","RHEA_ID":13632,"DIRECTION":"BI","MASTER_ID":13629,"compounds":"(1S,5R)-carveol + NADP(+) <=> (R)-carvone + H(+) + NADPH","pmd":2.016}
{"X":2709,"KEGG":"R03114","RHEA_ID":13632,"DIRECTION":"BI","MASTER_ID":13629,"compounds":"(1S,5R)-carveol + NADP(+) <=> (R)-carvone + H(+) + NADPH","pmd":593.979}
{"X":2710,"KEGG":"R03116","RHEA_ID":16044,"DIRECTION":"BI","MASTER_ID":16041,"metacyc":"13-BETA-OLIGOGLUCAN-PHOSPHORYLASE-RXN","compounds":"[(1->3)-beta-D-glucosyl](n) + phosphate <=> [(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate"}
{"X":2711,"KEGG":"R03118","RHEA_ID":21479,"DIRECTION":"BI","MASTER_ID":21476,"metacyc":"13-BETA-GLUCAN-SYNTHASE-RXN","compounds":"[(1->3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose <=> [(1->3)-beta-D-glucosyl](n+1) + H(+) + UDP","pmd":162.053}
{"X":2712,"KEGG":"R03119","RHEA_ID":23191,"DIRECTION":"BI","MASTER_ID":23188,"metacyc":"13-PROPANEDIOL-DEHYDROGENASE-RXN","compounds":"NAD(+) + propane-1,3-diol <=> 3-hydroxypropanal + H(+) + NADH"}
{"X":2713,"KEGG":"R03120","RHEA_ID":17536,"DIRECTION":"BI","MASTER_ID":17533,"ecocyc":"2.6.1.57-RXN","metacyc":"2.6.1.57-RXN","compounds":"2-oxoglutarate + an aromatic L-alpha-amino acid <=> an aromatic oxo-acid + L-glutamate","pmd":1.032}
{"X":2714,"KEGG":"R03121","RHEA_ID":10903,"DIRECTION":"BI","MASTER_ID":10900,"metacyc":"2.6.1.60-RXN","compounds":"an aromatic L-alpha-amino acid + glyoxylate <=> an aromatic oxo-acid + glycine"}
{"X":2715,"KEGG":"R03122","RHEA_ID":23983,"DIRECTION":"BI","MASTER_ID":23980,"compounds":"cyclomaltodextrin + H2O <=> linear maltodextrin"}
{"X":2716,"KEGG":"R03123","RHEA_ID":23019,"DIRECTION":"BI","MASTER_ID":23016,"compounds":"(2R,3S,4S)-3,4-leucopelargonidin + NADP(+) <=> (2R,3R)-dihydrokaempferol + H(+) + NADPH","pmd":456.02}
{"X":2717,"KEGG":"R03123","RHEA_ID":23019,"DIRECTION":"BI","MASTER_ID":23016,"compounds":"(2R,3S,4S)-3,4-leucopelargonidin + NADP(+) <=> (2R,3R)-dihydrokaempferol + H(+) + NADPH","pmd":2.016}
{"X":2718,"KEGG":"R03124","RHEA_ID":61115,"DIRECTION":"BI","MASTER_ID":61112,"compounds":"(2R,3R)-dihydrokaempferol + O2 + reduced [NADPH--hemoprotein reductase] <=> (2R,3R)-dihydroquercetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":2719,"KEGG":"R03125","RHEA_ID":61111,"DIRECTION":"BI","MASTER_ID":61108,"compounds":"(2R,3R)-dihydrokaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (2R,3R)-dihydromyricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]","pmd":31.99}
{"X":2720,"KEGG":"R03126","RHEA_ID":61135,"DIRECTION":"BI","MASTER_ID":61132,"compounds":"(2R,3R)-dihydrokaempferol + 2-oxoglutarate + O2 <=> CO2 + H(+) + H2O + kaempferol + succinate","pmd":2.016}
{"X":2721,"KEGG":"R03126","RHEA_ID":61135,"DIRECTION":"BI","MASTER_ID":61132,"compounds":"(2R,3R)-dihydrokaempferol + 2-oxoglutarate + O2 <=> CO2 + H(+) + H2O + kaempferol + succinate","pmd":27.995}
{"X":2722,"KEGG":"R03127","RHEA_ID":13848,"DIRECTION":"BI","MASTER_ID":13845,"compounds":"dihydroxyfumarate + H(+) <=> 2-hydroxy-3-oxopropanoate + CO2","pmd":43.99}
{"X":2723,"KEGG":"R03129","RHEA_ID":15640,"DIRECTION":"BI","MASTER_ID":15637,"compounds":"[alginate](n) + GDP-alpha-D-mannuronate <=> [alginate](n+1) + GDP + H(+)","pmd":176.032}
{"X":2724,"KEGG":"R03130","RHEA_ID":15576,"DIRECTION":"BI","MASTER_ID":15573,"compounds":"N-acetylserotonin + S-adenosyl-L-methionine <=> H(+) + melatonin + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":2725,"KEGG":"R03131","RHEA_ID":11499,"DIRECTION":"BI","MASTER_ID":11496,"compounds":"O-acetyl-L-serine + uracil <=> 3-(uracil-1-yl)-L-alanine + acetate + H(+)","pmd":87.032}
{"X":2726,"KEGG":"R03131","RHEA_ID":11499,"DIRECTION":"BI","MASTER_ID":11496,"compounds":"O-acetyl-L-serine + uracil <=> 3-(uracil-1-yl)-L-alanine + acetate + H(+)","pmd":52.006}
{"X":2727,"KEGG":"R03132","RHEA_ID":30894,"DIRECTION":"BI","MASTER_ID":30891,"metacyc":"SULFOCYS-RXN","compounds":"O-acetyl-L-serine + thiosulfate <=> acetate + H(+) + S-sulfo-L-cysteine","pmd":53.923}
{"X":2728,"KEGG":"R03133","RHEA_ID":17336,"DIRECTION":"BI","MASTER_ID":17333,"compounds":"O-acetyl-L-serine + zeatin <=> acetate + H(+) + L-lupinate","pmd":87.032}
{"X":2729,"KEGG":"R03133","RHEA_ID":17336,"DIRECTION":"BI","MASTER_ID":17333,"compounds":"O-acetyl-L-serine + zeatin <=> acetate + H(+) + L-lupinate","pmd":159.091}
{"X":2730,"KEGG":"R03134","RHEA_ID":13120,"DIRECTION":"BI","MASTER_ID":13117,"compounds":"O-acetyl-L-serine + pyrazole <=> 3-(pyrazol-1-yl)-L-alanine + acetate + H(+)","pmd":8.016}
{"X":2731,"KEGG":"R03135","RHEA_ID":21691,"DIRECTION":"BI","MASTER_ID":21688,"compounds":"a polyvinyl alcohol + n O2 <=> an oxidized polyvinyl alcohol + n H2O2"}
{"X":2732,"KEGG":"R03136","RHEA_ID":20160,"DIRECTION":"BI","MASTER_ID":20157,"compounds":"2n [Fe(III)cytochrome c] + a polyvinyl alcohol <=> 2n [Fe(II)cytochrome c] + an oxidized polyvinyl alcohol + 2n H(+)"}
{"X":2733,"KEGG":"R03137","RHEA_ID":14768,"DIRECTION":"BI","MASTER_ID":14765,"compounds":"coelenterazine h + O2 <=> CO2 + excited coelenteramide h monoanion + H(+) + hnu","pmd":12}
{"X":2734,"KEGG":"R03138","RHEA_ID":20484,"DIRECTION":"BI","MASTER_ID":20481,"compounds":"3'-phosphoadenylyl sulfate + coelenterazine h <=> adenosine 3',5'-bisphosphate + H(+) + luciferyl sulfate","pmd":19.866}
{"X":2735,"KEGG":"R03139","RHEA_ID":30898,"DIRECTION":"BI","MASTER_ID":30895,"compounds":"H2O + O2 + propane-1,3-diamine <=> 3-aminopropanal + H2O2 + NH4(+)"}
{"X":2736,"KEGG":"R03140","RHEA_ID":36634,"DIRECTION":"BI","MASTER_ID":36631,"compounds":"D-ribulose 1,5-bisphosphate + O2 <=> (2R)-3-phosphoglycerate + 2-phosphoglycolate + 2 H(+)","pmd":123.993}
{"X":2737,"KEGG":"R03145","RHEA_ID":29170,"DIRECTION":"BI","MASTER_ID":29167,"ecocyc":"PYRUVOXID-RXN","compounds":"H2O + pyruvate + ubiquinone-8 <=> acetate + CO2 + ubiquinol-8"}
{"X":2738,"KEGG":"R03146","RHEA_ID":21523,"DIRECTION":"BI","MASTER_ID":21520,"compounds":"2 [Fe(III)-cytochrome b1] + formate <=> 2 [Fe(II)-cytochrome b1] + CO2 + H(+)"}
{"X":2739,"KEGG":"R03147","RHEA_ID":18680,"DIRECTION":"BI","MASTER_ID":18677,"compounds":"[Fe(III)-cytochrome b5] + L-ascorbate <=> [Fe(II)-cytochrome b5] + H(+) + monodehydro-L-ascorbate radical"}
{"X":2740,"KEGG":"R03148","RHEA_ID":10975,"DIRECTION":"BI","MASTER_ID":10972,"compounds":"D-hexose + H(+) + phosphoramidate <=> alpha-D-hexose 1-phosphate + NH4(+)","pmd":79.966}
{"X":2741,"KEGG":"R03149","RHEA_ID":20931,"DIRECTION":"BI","MASTER_ID":20928,"metacyc":"2.7.7.28-RXN","compounds":"[DsbA protein]-dithiol + a quinone <=> [DsbA protein]-disulfide + a quinol"}
{"X":2742,"KEGG":"R03150","RHEA_ID":22007,"DIRECTION":"BI","MASTER_ID":22004,"metacyc":"2.7.11.18-RXN","compounds":"[myosin light chain]-L-serine + ATP <=> [myosin light chain]-O-phospho-L-serine + ADP + H(+)","pmd":79.966}
{"X":2743,"KEGG":"R03151","RHEA_ID":12852,"DIRECTION":"BI","MASTER_ID":12849,"compounds":"[myosin light chain]-O-phospho-L-serine + H2O <=> [myosin light chain]-L-serine + phosphate"}
{"X":2744,"KEGG":"R03154","RHEA_ID":38290,"DIRECTION":"BI","MASTER_ID":38287,"metacyc":"2.8.3.7-RXN","compounds":"(3S)-citramalate + succinyl-CoA <=> (3S)-citramalyl-CoA + succinate","pmd":30.01}
{"X":2745,"KEGG":"R03154","RHEA_ID":38290,"DIRECTION":"BI","MASTER_ID":38287,"metacyc":"2.8.3.7-RXN","compounds":"(3S)-citramalate + succinyl-CoA <=> (3S)-citramalyl-CoA + succinate","pmd":30.011}
{"X":2746,"KEGG":"R03155","RHEA_ID":18984,"DIRECTION":"BI","MASTER_ID":18981,"ecocyc":"1.1.1.168-RXN","compounds":"(R)-pantolactone + NADP(+) <=> 2-dehydropantolactone + H(+) + NADPH","pmd":2.016}
{"X":2747,"KEGG":"R03155","RHEA_ID":18984,"DIRECTION":"BI","MASTER_ID":18981,"ecocyc":"1.1.1.168-RXN","compounds":"(R)-pantolactone + NADP(+) <=> 2-dehydropantolactone + H(+) + NADPH","pmd":616.036}
{"X":2748,"KEGG":"R03155","RHEA_ID":18984,"DIRECTION":"BI","MASTER_ID":18981,"ecocyc":"DEHYDROPANTLACRED-RXN","compounds":"(R)-pantolactone + NADP(+) <=> 2-dehydropantolactone + H(+) + NADPH","pmd":2.016}
{"X":2749,"KEGG":"R03155","RHEA_ID":18984,"DIRECTION":"BI","MASTER_ID":18981,"ecocyc":"DEHYDROPANTLACRED-RXN","compounds":"(R)-pantolactone + NADP(+) <=> 2-dehydropantolactone + H(+) + NADPH","pmd":616.036}
{"X":2750,"KEGG":"R03156","RHEA_ID":21007,"DIRECTION":"BI","MASTER_ID":21004,"compounds":"(R)-pantolactone + A <=> 2-dehydropantolactone + AH2","pmd":2.016}
{"X":2751,"KEGG":"R03161","RHEA_ID":13244,"DIRECTION":"BI","MASTER_ID":13241,"compounds":"ATP + L-fucose <=> ADP + beta-L-fucose 1-phosphate + H(+)","pmd":79.966}
{"X":2752,"KEGG":"R03162","RHEA_ID":12291,"DIRECTION":"BI","MASTER_ID":12288,"compounds":"an alpha-L-fucoside + H2O <=> an alcohol + L-fucose"}
{"X":2753,"KEGG":"R03163","RHEA_ID":17236,"DIRECTION":"BI","MASTER_ID":17233,"ecocyc":"FUCISOM-RXN","metacyc":"FUCISOM-RXN","compounds":"L-fucose <=> L-fuculose","pmd":0}
{"X":2754,"KEGG":"R03164","RHEA_ID":17228,"DIRECTION":"BI","MASTER_ID":17225,"compounds":"1,4,5,6-tetrahydro-6-oxonicotinate + oxidized 2[4Fe-4S]-[ferredoxin] <=> 6-hydroxynicotinate + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]","pmd":2.016}
{"X":2755,"KEGG":"R03165","RHEA_ID":18968,"DIRECTION":"BI","MASTER_ID":18965,"ecocyc":"UROGENIIISYN-RXN","metacyc":"UROGENIIISYN-RXN","compounds":"hydroxymethylbilane <=> H2O + uroporphyrinogen III","pmd":18.011}
{"X":2756,"KEGG":"R03167","RHEA_ID":19060,"DIRECTION":"BI","MASTER_ID":19057,"compounds":"a hydroperoxy polyunsaturated fatty acid + 2 glutathione <=> a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O","pmd":305.068}
{"X":2757,"KEGG":"R03168","RHEA_ID":22391,"DIRECTION":"BI","MASTER_ID":22388,"compounds":"acetyl-CoA + N(6)-hydroxy-L-lysine <=> CoA + N(6)-acetyl-N(6)-hydroxy-L-lysine","pmd":42.011}
{"X":2758,"KEGG":"R03169","RHEA_ID":24535,"DIRECTION":"BI","MASTER_ID":24532,"metacyc":"1.3.1.52-RXN","compounds":"2-methylbutanoyl-CoA + NAD(+) <=> 2-methylbut-2-enoyl-CoA + H(+) + NADH","pmd":2.016}
{"X":2759,"KEGG":"R03169","RHEA_ID":43783,"DIRECTION":"BI","MASTER_ID":43780,"metacyc":"2-METHYLACYL-COA-DEHYDROGENASE-RXN","compounds":"2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-2-methylbutenoyl-CoA + reduced [electron-transfer flavoprotein]","pmd":2.016}
{"X":2760,"KEGG":"R03171","RHEA_ID":30910,"DIRECTION":"BI","MASTER_ID":30907,"metacyc":"2KETO-3METHYLVALERATE-RXN","compounds":"(S)-3-methyl-2-oxopentanoate + CoA + NAD(+) <=> 2-methylbutanoyl-CoA + CO2 + NADH","pmd":535.062}
{"X":2761,"KEGG":"R03171","RHEA_ID":30910,"DIRECTION":"BI","MASTER_ID":30907,"metacyc":"2KETO-3METHYLVALERATE-RXN","compounds":"(S)-3-methyl-2-oxopentanoate + CoA + NAD(+) <=> 2-methylbutanoyl-CoA + CO2 + NADH","pmd":84.058}
{"X":2762,"KEGG":"R03171","RHEA_ID":30910,"DIRECTION":"BI","MASTER_ID":30907,"metacyc":"2KETO-3METHYLVALERATE-RXN","compounds":"(S)-3-methyl-2-oxopentanoate + CoA + NAD(+) <=> 2-methylbutanoyl-CoA + CO2 + NADH","pmd":187.056}
{"X":2763,"KEGG":"R03173","RHEA_ID":13264,"DIRECTION":"BI","MASTER_ID":13261,"metacyc":"2-MEBUCOA-FAD-RXN","compounds":"2-methylbutanoyl-CoA + A <=> 2-methylbut-2-enoyl-CoA + AH2","pmd":2.016}
{"X":2764,"KEGG":"R03176","RHEA_ID":24079,"DIRECTION":"BI","MASTER_ID":24076,"metacyc":"1.1.1.145-RXN","compounds":"a 3beta-hydroxy-Delta(5)-steroid + NAD(+) <=> a 3-oxo-Delta(5)-steroid + H(+) + NADH","pmd":391.903}
{"X":2765,"KEGG":"R03176","RHEA_ID":24079,"DIRECTION":"BI","MASTER_ID":24076,"metacyc":"1.1.1.145-RXN","compounds":"a 3beta-hydroxy-Delta(5)-steroid + NAD(+) <=> a 3-oxo-Delta(5)-steroid + H(+) + NADH","pmd":2.016}
{"X":2766,"KEGG":"R03177","RHEA_ID":14384,"DIRECTION":"BI","MASTER_ID":14381,"compounds":"4-guanidinobutanal + H2O + NAD(+) <=> 4-guanidinobutanoate + 2 H(+) + NADH","pmd":15.995}
{"X":2767,"KEGG":"R03177","RHEA_ID":14384,"DIRECTION":"BI","MASTER_ID":14381,"compounds":"4-guanidinobutanal + H2O + NAD(+) <=> 4-guanidinobutanoate + 2 H(+) + NADH","pmd":519.032}
{"X":2768,"KEGG":"R03178","RHEA_ID":11343,"DIRECTION":"BI","MASTER_ID":11340,"compounds":"5-guanidino-2-oxopentanoate + H(+) <=> 4-guanidinobutanal + CO2","pmd":43.99}
{"X":2769,"KEGG":"R03180","RHEA_ID":34378,"DIRECTION":"BI","MASTER_ID":34375,"compounds":"4-guanidinobutanamide + H2O <=> 4-guanidinobutanoate + NH4(+)","pmd":0.984}
{"X":2770,"KEGG":"R03181","RHEA_ID":14820,"DIRECTION":"BI","MASTER_ID":14817,"compounds":"4-maleylacetoacetate <=> 4-fumarylacetoacetate","pmd":0}
{"X":2771,"KEGG":"R03182","RHEA_ID":15808,"DIRECTION":"BI","MASTER_ID":15805,"compounds":"7,8-diaminononanoate + ATP + CO2 <=> ADP + dethiobiotin + 3 H(+) + phosphate","pmd":25.979}
{"X":2772,"KEGG":"R03182","RHEA_ID":15808,"DIRECTION":"BI","MASTER_ID":15805,"compounds":"7,8-diaminononanoate + ATP + CO2 <=> ADP + dethiobiotin + 3 H(+) + phosphate","pmd":79.966}
{"X":2773,"KEGG":"R03183","RHEA_ID":18928,"DIRECTION":"BI","MASTER_ID":18925,"compounds":"L-gulono-1,4-lactone + NADP(+) <=> D-glucurono-3,6-lactone + H(+) + NADPH","pmd":568.051}
{"X":2774,"KEGG":"R03183","RHEA_ID":18928,"DIRECTION":"BI","MASTER_ID":18925,"compounds":"L-gulono-1,4-lactone + NADP(+) <=> D-glucurono-3,6-lactone + H(+) + NADPH","pmd":2.016}
{"X":2775,"KEGG":"R03184","RHEA_ID":12355,"DIRECTION":"BI","MASTER_ID":12352,"compounds":"L-gulono-1,4-lactone + O2 <=> H2O2 + L-xylo-hex-3-ulonolactone","pmd":2.016}
{"X":2776,"KEGG":"R03186","RHEA_ID":30270,"DIRECTION":"BI","MASTER_ID":30267,"compounds":"2 monodehydro-L-ascorbate radical <=> L-ascorbate + L-dehydroascorbate"}
{"X":2777,"KEGG":"R03187","RHEA_ID":11723,"DIRECTION":"BI","MASTER_ID":11720,"compounds":"ATP + 2 H2O + N-methylhydantoin <=> ADP + 2 H(+) + N-carbamoylsarcosine + phosphate","pmd":79.966}
{"X":2778,"KEGG":"R03187","RHEA_ID":11723,"DIRECTION":"BI","MASTER_ID":11720,"compounds":"ATP + 2 H2O + N-methylhydantoin <=> ADP + 2 H(+) + N-carbamoylsarcosine + phosphate","pmd":18.011}
{"X":2779,"KEGG":"R03188","RHEA_ID":13664,"DIRECTION":"BI","MASTER_ID":13661,"compounds":"H2O + N-formimidoyl-L-aspartate <=> N-formyl-L-aspartate + NH4(+)","pmd":0.984}
{"X":2780,"KEGG":"R03189","RHEA_ID":23243,"DIRECTION":"BI","MASTER_ID":23240,"compounds":"5-formyltetrahydrofolate + L-glutamate <=> (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-glutamate","pmd":27.995}
{"X":2781,"KEGG":"R03192","RHEA_ID":12251,"DIRECTION":"BI","MASTER_ID":12248,"compounds":"NADP(+) + UDP-N-acetyl-alpha-D-muramate <=> H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine","pmd":2.016}
{"X":2782,"KEGG":"R03192","RHEA_ID":12251,"DIRECTION":"BI","MASTER_ID":12248,"compounds":"NADP(+) + UDP-N-acetyl-alpha-D-muramate <=> H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine","pmd":66.996}
{"X":2783,"KEGG":"R03193","RHEA_ID":23375,"DIRECTION":"BI","MASTER_ID":23372,"compounds":"ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine","pmd":71.037}
{"X":2784,"KEGG":"R03193","RHEA_ID":23375,"DIRECTION":"BI","MASTER_ID":23372,"compounds":"ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine","pmd":79.966}
{"X":2785,"KEGG":"R03194","RHEA_ID":32462,"DIRECTION":"BI","MASTER_ID":32459,"compounds":"2 S-adenosyl-L-methionine + uroporphyrinogen III <=> H(+) + precorrin-2 + 2 S-adenosyl-L-homocysteine","pmd":28.031}
{"X":2786,"KEGG":"R03194","RHEA_ID":32462,"DIRECTION":"BI","MASTER_ID":32459,"compounds":"2 S-adenosyl-L-methionine + uroporphyrinogen III <=> H(+) + precorrin-2 + 2 S-adenosyl-L-homocysteine","pmd":14.016}
{"X":2787,"KEGG":"R03197","RHEA_ID":19868,"DIRECTION":"BI","MASTER_ID":19865,"compounds":"4 H(+) + uroporphyrinogen III <=> 4 CO2 + coproporphyrinogen III","pmd":175.959}
{"X":2788,"KEGG":"R03198","RHEA_ID":19352,"DIRECTION":"BI","MASTER_ID":19349,"compounds":"(R)-4-dehydropantoate + H2O + NAD(+) <=> (R)-3,3-dimethylmalate + 2 H(+) + NADH","pmd":15.995}
{"X":2789,"KEGG":"R03198","RHEA_ID":19352,"DIRECTION":"BI","MASTER_ID":19349,"compounds":"(R)-4-dehydropantoate + H2O + NAD(+) <=> (R)-3,3-dimethylmalate + 2 H(+) + NADH","pmd":502.064}
{"X":2790,"KEGG":"R03199","RHEA_ID":14624,"DIRECTION":"BI","MASTER_ID":14621,"compounds":"(S)-2,3-epoxysqualene <=> lanosterol","pmd":0}
{"X":2791,"KEGG":"R03200","RHEA_ID":21311,"DIRECTION":"BI","MASTER_ID":21308,"compounds":"(S)-2,3-epoxysqualene <=> cycloartenol","pmd":0}
{"X":2792,"KEGG":"R03202","RHEA_ID":11883,"DIRECTION":"BI","MASTER_ID":11880,"compounds":"(S)-6-hydroxynicotine + H2O + O2 <=> 6-hydroxypseudooxynicotine + H2O2","pmd":15.995}
{"X":2793,"KEGG":"R03203","RHEA_ID":11391,"DIRECTION":"BI","MASTER_ID":11388,"metacyc":"11-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN","compounds":"an 11beta-hydroxysteroid + NADP(+) <=> an 11-oxosteroid + H(+) + NADPH"}
{"X":2794,"KEGG":"R03206","RHEA_ID":16976,"DIRECTION":"BI","MASTER_ID":16973,"compounds":"2-hydroxypyridine + AH2 + O2 <=> 2,5-dihydroxypyridine + A + H2O"}
{"X":2795,"KEGG":"R03207","RHEA_ID":19784,"DIRECTION":"BI","MASTER_ID":19781,"metacyc":"DIIODOTYROSINE-AMINOTRANSFERASE-RXN","compounds":"2-oxoglutarate + 3,5-diiodo-L-tyrosine <=> 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + L-glutamate","pmd":1.032}
{"X":2796,"KEGG":"R03209","RHEA_ID":14784,"DIRECTION":"BI","MASTER_ID":14781,"metacyc":"6-CARBOXYHEXANOATE--COA-LIGASE-RXN","compounds":"ATP + CoA + heptanedioate <=> 6-carboxyhexanoyl-CoA + AMP + diphosphate","pmd":142.063}
{"X":2797,"KEGG":"R03209","RHEA_ID":14784,"DIRECTION":"BI","MASTER_ID":14781,"metacyc":"6-CARBOXYHEXANOATE--COA-LIGASE-RXN","compounds":"ATP + CoA + heptanedioate <=> 6-carboxyhexanoyl-CoA + AMP + diphosphate","pmd":159.933}
{"X":2798,"KEGG":"R03209","RHEA_ID":14784,"DIRECTION":"BI","MASTER_ID":14781,"metacyc":"6-CARBOXYHEXANOATE--COA-LIGASE-RXN","compounds":"ATP + CoA + heptanedioate <=> 6-carboxyhexanoyl-CoA + AMP + diphosphate","pmd":186.99}
{"X":2799,"KEGG":"R03210","RHEA_ID":42291,"DIRECTION":"BI","MASTER_ID":42288,"compounds":"6-carboxyhexanoyl-[ACP] + H(+) + L-alanine <=> 8-amino-7-oxononanoate + CO2 + holo-[ACP]","pmd":142.063}
{"X":2800,"KEGG":"R03210","RHEA_ID":20715,"DIRECTION":"BI","MASTER_ID":20712,"metacyc":"7KAPSYN-RXN","compounds":"6-carboxyhexanoyl-CoA + H(+) + L-alanine <=> 8-amino-7-oxononanoate + CO2 + CoA","pmd":142.063}
{"X":2801,"KEGG":"R03211","RHEA_ID":16476,"DIRECTION":"BI","MASTER_ID":16473,"compounds":"cyclohexane-1,3-dione + H2O <=> 5-oxohexanoate + H(+)","pmd":18.011}
{"X":2802,"KEGG":"R03212","RHEA_ID":15908,"DIRECTION":"BI","MASTER_ID":15905,"compounds":"3-hydroxycyclohexanone + A <=> AH2 + cyclohexane-1,3-dione","pmd":2.016}
{"X":2803,"KEGG":"R03213","RHEA_ID":13760,"DIRECTION":"BI","MASTER_ID":13757,"compounds":"(Z)-2-phenyl-1-thioacetohydroximate + UDP-alpha-D-glucose <=> (Z)-desulfoglucotropeolin + UDP","pmd":162.053}
{"X":2804,"KEGG":"R03214","RHEA_ID":20284,"DIRECTION":"BI","MASTER_ID":20281,"compounds":"3'-phosphoadenylyl sulfate + desulfoglucotropeolin <=> adenosine 3',5'-bisphosphate + glucotropeolin + H(+)","pmd":79.957}
{"X":2805,"KEGG":"R03215","RHEA_ID":15192,"DIRECTION":"BI","MASTER_ID":15189,"metacyc":"1.2.2.3-RXN","compounds":"2 [Fe(III)cytochrome c553] + formate <=> 2 [Fe(II)cytochrome c553] + CO2 + H(+)"}
{"X":2806,"KEGG":"R03216","RHEA_ID":15520,"DIRECTION":"BI","MASTER_ID":15517,"compounds":"H2O + N(2),6-disulfo-D-glucosamine <=> H(+) + N-sulfo-D-glucosamine + sulfate","pmd":79.957}
{"X":2807,"KEGG":"R03217","RHEA_ID":30934,"DIRECTION":"BI","MASTER_ID":30931,"metacyc":"RXN-721","compounds":"L-cysteine + O-acetyl-L-homoserine <=> acetate + H(+) + L,L-cystathionine","pmd":60.999}
{"X":2808,"KEGG":"R03217","RHEA_ID":30934,"DIRECTION":"BI","MASTER_ID":30931,"metacyc":"RXN-721","compounds":"L-cysteine + O-acetyl-L-homoserine <=> acetate + H(+) + L,L-cystathionine","pmd":101.048}
{"X":2809,"KEGG":"R03218","RHEA_ID":22875,"DIRECTION":"BI","MASTER_ID":22872,"compounds":"2-oxoglutarate + L-prolyl-[procollagen] + O2 <=> CO2 + succinate + trans-3-hydroxy-L-prolyl-[procollagen]","pmd":27.995}
{"X":2810,"KEGG":"R03219","RHEA_ID":18948,"DIRECTION":"BI","MASTER_ID":18945,"compounds":"2-oxoglutarate + L-prolyl-[procollagen] + O2 <=> CO2 + succinate + trans-4-hydroxy-L-prolyl-[procollagen]","pmd":27.995}
{"X":2811,"KEGG":"R03220","RHEA_ID":18260,"DIRECTION":"BI","MASTER_ID":18257,"compounds":"coproporphyrinogen III + 2 H(+) + O2 <=> 2 CO2 + 2 H2O + protoporphyrinogen IX","pmd":92.011}
{"X":2812,"KEGG":"R03222","RHEA_ID":25579,"DIRECTION":"BI","MASTER_ID":25576,"compounds":"3 O2 + protoporphyrinogen IX <=> 3 H2O2 + protoporphyrin IX","pmd":6.047}
{"X":2813,"KEGG":"R03223","RHEA_ID":22331,"DIRECTION":"BI","MASTER_ID":22328,"compounds":"4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) <=> diphosphate + thiamine phosphate","pmd":46.071}
{"X":2814,"KEGG":"R03223","RHEA_ID":22331,"DIRECTION":"BI","MASTER_ID":22328,"compounds":"4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) <=> diphosphate + thiamine phosphate","pmd":122.072}
{"X":2815,"KEGG":"R03225","RHEA_ID":23051,"DIRECTION":"BI","MASTER_ID":23048,"metacyc":"HYDROXYACID-OXOACID-TRANSHYDROGENASE-RXN","compounds":"(S)-3-hydroxybutanoate + 2-oxoglutarate <=> (R)-2-hydroxyglutarate + acetoacetate","pmd":2.016}
{"X":2816,"KEGG":"R03226","RHEA_ID":19864,"DIRECTION":"BI","MASTER_ID":19861,"compounds":"a 16alpha-hydroxysteroid + NAD(+) <=> a 16-oxosteroid + H(+) + NADH","pmd":2.016}
{"X":2817,"KEGG":"R03226","RHEA_ID":19864,"DIRECTION":"BI","MASTER_ID":19861,"compounds":"a 16alpha-hydroxysteroid + NAD(+) <=> a 16-oxosteroid + H(+) + NADH","pmd":373.892}
{"X":2818,"KEGG":"R03227","RHEA_ID":19860,"DIRECTION":"BI","MASTER_ID":19857,"compounds":"a 16alpha-hydroxysteroid + NADP(+) <=> a 16-oxosteroid + H(+) + NADPH","pmd":2.016}
{"X":2819,"KEGG":"R03227","RHEA_ID":19860,"DIRECTION":"BI","MASTER_ID":19857,"compounds":"a 16alpha-hydroxysteroid + NADP(+) <=> a 16-oxosteroid + H(+) + NADPH","pmd":453.859}
{"X":2820,"KEGG":"R03228","RHEA_ID":15832,"DIRECTION":"BI","MASTER_ID":15829,"compounds":"a 16alpha-hydroxysteroid <=> a 16beta-hydroxysteroid","pmd":0}
{"X":2821,"KEGG":"R03230","RHEA_ID":24499,"DIRECTION":"BI","MASTER_ID":24496,"compounds":"4-O-deacetylvindoline + acetyl-CoA <=> CoA + vindoline","pmd":42.011}
{"X":2822,"KEGG":"R03230","RHEA_ID":24499,"DIRECTION":"BI","MASTER_ID":24496,"compounds":"4-O-deacetylvindoline + acetyl-CoA <=> CoA + vindoline","pmd":42.01}
{"X":2823,"KEGG":"R03231","RHEA_ID":16864,"DIRECTION":"BI","MASTER_ID":16861,"ecocyc":"DAPASYN-RXN","metacyc":"DAPASYN-RXN","compounds":"8-amino-7-oxononanoate + S-adenosyl-L-methionine <=> 7,8-diaminononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate","pmd":0.024}
{"X":2824,"KEGG":"R03231","RHEA_ID":16864,"DIRECTION":"BI","MASTER_ID":16861,"ecocyc":"DAPASYN-RXN","metacyc":"DAPASYN-RXN","compounds":"8-amino-7-oxononanoate + S-adenosyl-L-methionine <=> 7,8-diaminononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate","pmd":1.032}
{"X":2825,"KEGG":"R03232","RHEA_ID":49255,"DIRECTION":"BI","MASTER_ID":49252,"compounds":"D-fructose(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-fructose 1-phosphate(in) + L-histidyl-[protein]","pmd":79.966}
{"X":2826,"KEGG":"R03236","RHEA_ID":12423,"DIRECTION":"BI","MASTER_ID":12420,"compounds":"ATP + D-tagatofuranose 6-phosphate <=> ADP + D-tagatofuranose 1,6-bisphosphate + H(+)","pmd":79.966}
{"X":2827,"KEGG":"R03240","RHEA_ID":13036,"DIRECTION":"BI","MASTER_ID":13033,"metacyc":"LACTOSE-6-PHOSPHATE-ISOMERASE-RXN","compounds":"aldehydo-D-galactose 6-phosphate <=> keto-D-tagatose 6-phosphate","pmd":0}
{"X":2828,"KEGG":"R03241","RHEA_ID":12379,"DIRECTION":"BI","MASTER_ID":12376,"compounds":"ATP + L-fuculose <=> ADP + H(+) + L-fuculose 1-phosphate","pmd":79.966}
{"X":2829,"KEGG":"R03243","RHEA_ID":23747,"DIRECTION":"BI","MASTER_ID":23744,"ecocyc":"HISTAMINOTRANS-RXN","metacyc":"HISTAMINOTRANS-RXN","compounds":"2-oxoglutarate + L-histidinol phosphate <=> 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate","pmd":1.032}
{"X":2830,"KEGG":"R03244","RHEA_ID":18500,"DIRECTION":"BI","MASTER_ID":18497,"compounds":"L-ribulose 5-phosphate <=> L-xylulose 5-phosphate","pmd":0}
{"X":2831,"KEGG":"R03245","RHEA_ID":16344,"DIRECTION":"BI","MASTER_ID":16341,"metacyc":"PHOSPHOMEVALONATE-KINASE-RXN","compounds":"(R)-5-phosphomevalonate + ATP <=> (R)-5-diphosphomevalonate + ADP","pmd":79.966}
{"X":2832,"KEGG":"R03246","RHEA_ID":19676,"DIRECTION":"BI","MASTER_ID":19673,"compounds":"1,2,3-trihydroxybenzene + O2 <=> (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+)","pmd":31.99}
{"X":2833,"KEGG":"R03247","RHEA_ID":12752,"DIRECTION":"BI","MASTER_ID":12749,"metacyc":"GALLATE-DECARBOXYLASE-RXN","compounds":"3,4,5-trihydroxybenzoate + H(+) <=> 1,2,3-trihydroxybenzene + CO2","pmd":43.99}
{"X":2834,"KEGG":"R03248","RHEA_ID":16020,"DIRECTION":"BI","MASTER_ID":16017,"metacyc":"25-DIAMINOVALERATE-AMINOTRANSFERASE-RXN","compounds":"2-oxoglutarate + L-ornithine <=> 5-amino-2-oxopentanoate + L-glutamate","pmd":1.032}
{"X":2835,"KEGG":"R03251","RHEA_ID":22251,"DIRECTION":"BI","MASTER_ID":22248,"compounds":"7,8-dihydro-7,8-dihydroxykynurenate + NAD(+) <=> 7,8-dihydroxykynurenate + H(+) + NADH","pmd":443.084}
{"X":2836,"KEGG":"R03251","RHEA_ID":22251,"DIRECTION":"BI","MASTER_ID":22248,"compounds":"7,8-dihydro-7,8-dihydroxykynurenate + NAD(+) <=> 7,8-dihydroxykynurenate + H(+) + NADH","pmd":2.016}
{"X":2837,"KEGG":"R03253","RHEA_ID":23403,"DIRECTION":"BI","MASTER_ID":23400,"compounds":"7,8-dihydroxykynurenate + O2 <=> 5-(3-carboxy-3-oxoprop-1-en-1-yl)-4,6-dihydroxypyridine-2-carboxylate + H(+)","pmd":31.99}
{"X":2838,"KEGG":"R03254","RHEA_ID":14056,"DIRECTION":"BI","MASTER_ID":14053,"compounds":"D-arabinose 5-phosphate + H2O + phosphoenolpyruvate <=> 3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + phosphate","pmd":88.016}
{"X":2839,"KEGG":"R03255","RHEA_ID":24571,"DIRECTION":"BI","MASTER_ID":24568,"compounds":"a 6-phospho-beta-D-galactoside + H2O <=> an alcohol + D-galactose 6-phosphate"}
{"X":2840,"KEGG":"R03256","RHEA_ID":42407,"DIRECTION":"BI","MASTER_ID":42404,"compounds":"H2O + lactose 6-phosphate <=> beta-D-glucose + D-galactose 6-phosphate","pmd":162.053}
{"X":2841,"KEGG":"R03258","RHEA_ID":12716,"DIRECTION":"BI","MASTER_ID":12713,"compounds":"a nucleoside 5'-phosphate + ATP <=> a 5'-phosphonucleoside 3'-diphosphate + AMP + H(+)","pmd":159.933}
{"X":2842,"KEGG":"R03259","RHEA_ID":14656,"DIRECTION":"BI","MASTER_ID":14653,"compounds":"a nucleoside 3',5'-cyclic phosphate + H2O <=> a nucleoside 5'-phosphate + H(+)"}
{"X":2843,"KEGG":"R03260","RHEA_ID":20400,"DIRECTION":"BI","MASTER_ID":20397,"compounds":"L-cysteine + O-succinyl-L-homoserine <=> H(+) + L,L-cystathionine + succinate","pmd":2.993}
{"X":2844,"KEGG":"R03261","RHEA_ID":20863,"DIRECTION":"BI","MASTER_ID":20860,"compounds":"(1S,6R)-isopiperitenol + NAD(+) <=> (6R)-isopiperitenone + H(+) + NADH","pmd":2.016}
{"X":2845,"KEGG":"R03261","RHEA_ID":20863,"DIRECTION":"BI","MASTER_ID":20860,"compounds":"(1S,6R)-isopiperitenol + NAD(+) <=> (6R)-isopiperitenone + H(+) + NADH","pmd":514.012}
{"X":2846,"KEGG":"R03262","RHEA_ID":11875,"DIRECTION":"BI","MASTER_ID":11872,"compounds":"corticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 18-hydroxycorticosterone + H2O + 2 oxidized [adrenodoxin]","pmd":15.995}
{"X":2847,"KEGG":"R03263","RHEA_ID":50795,"DIRECTION":"BI","MASTER_ID":50792,"metacyc":"RXN66-361","compounds":"18-hydroxycorticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> aldosterone + 2 H2O + 2 oxidized [adrenodoxin]","pmd":2.016}
{"X":2848,"KEGG":"R03264","RHEA_ID":14700,"DIRECTION":"BI","MASTER_ID":14697,"metacyc":"FARNESOL-DEHYDROGENASE-RXN","compounds":"(2E,6E)-farnesol + NADP(+) <=> (2E,6E)-farnesal + H(+) + NADPH","pmd":523.901}
{"X":2849,"KEGG":"R03264","RHEA_ID":14700,"DIRECTION":"BI","MASTER_ID":14697,"metacyc":"FARNESOL-DEHYDROGENASE-RXN","compounds":"(2E,6E)-farnesol + NADP(+) <=> (2E,6E)-farnesal + H(+) + NADPH","pmd":2.016}
{"X":2850,"KEGG":"R03265","RHEA_ID":13404,"DIRECTION":"BI","MASTER_ID":13401,"compounds":"(2E,6E)-farnesol <=> (2Z,6E)-farnesol","pmd":0}
{"X":2851,"KEGG":"R03266","RHEA_ID":10483,"DIRECTION":"BI","MASTER_ID":10480,"metacyc":"4-HYDROXYGLUTAMATE-AMINOTRANSFERASE-RXN","compounds":"2-oxoglutarate + 4-hydroxy-L-glutamate <=> 4-hydroxy-2-oxoglutarate + L-glutamate","pmd":1.032}
{"X":2852,"KEGG":"R03267","RHEA_ID":22303,"DIRECTION":"BI","MASTER_ID":22300,"compounds":"a flavonol + UDP-alpha-D-glucose <=> a flavonol 3-O-beta-D-glucoside + H(+) + UDP","pmd":162.053}
{"X":2853,"KEGG":"R03268","RHEA_ID":19704,"DIRECTION":"BI","MASTER_ID":19701,"compounds":"a flavonol 3-O-glycoside + UDP-alpha-D-xylose <=> a flavonol 3-O-[beta-D-xylosyl-(1->2)-beta-D-glycoside] + H(+) + UDP","pmd":3.886}
{"X":2854,"KEGG":"R03269","RHEA_ID":16796,"DIRECTION":"BI","MASTER_ID":16793,"compounds":"H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine <=> CO2 + D-pantetheine 4'-phosphate","pmd":43.99}
{"X":2855,"KEGG":"R03271","RHEA_ID":23247,"DIRECTION":"BI","MASTER_ID":23244,"metacyc":"SYM-NORSPERMIDINE-SYNTHASE-RXN","compounds":"propane-1,3-diamine + S-adenosyl 3-(methylsulfanyl)propylamine <=> H(+) + norspermidine + S-methyl-5'-thioadenosine","pmd":58.066}
{"X":2856,"KEGG":"R03272","RHEA_ID":20336,"DIRECTION":"BI","MASTER_ID":20333,"metacyc":"2.7.11.27-RXN","compounds":"[acetyl-CoA carboxylase]-L-serine + ATP <=> [acetyl-CoA carboxylase]-O-phospho-L-serine + ADP + H(+)","pmd":79.966}
{"X":2857,"KEGG":"R03273","RHEA_ID":17128,"DIRECTION":"BI","MASTER_ID":17125,"metacyc":"ACETYL-COA-CARBOXYLASE-PHOSPHATASE-RXN","compounds":"H2O + N-(4-carboxy-4-oxobutanoyl)-L-ethylglycylglycine <=> 2-oxoglutarate + N-(2-aminobutanoyl)glycine"}
{"X":2858,"KEGG":"R03274","RHEA_ID":19432,"DIRECTION":"BI","MASTER_ID":19429,"metacyc":"2.7.11.15-RXN","compounds":"[beta-adrenergic receptor] + ATP <=> [beta-adrenergic receptor]-phosphate + ADP + H(+)","pmd":79.966}
{"X":2859,"KEGG":"R03275","RHEA_ID":21739,"DIRECTION":"BI","MASTER_ID":21736,"compounds":"(3S)-3,6-diaminohexanoate <=> (3S,5S)-3,5-diaminohexanoate","pmd":0}
{"X":2860,"KEGG":"R03276","RHEA_ID":21763,"DIRECTION":"BI","MASTER_ID":21760,"metacyc":"5.1.2.3-RXN","compounds":"(3S)-hydroxybutanoyl-CoA <=> (3R)-hydroxybutanoyl-CoA","pmd":0}
{"X":2861,"KEGG":"R03277","RHEA_ID":10271,"DIRECTION":"BI","MASTER_ID":10268,"metacyc":"4.1.2.20-RXN","compounds":"2-dehydro-3-deoxy-D-glucarate <=> 2-hydroxy-3-oxopropanoate + pyruvate","pmd":88.016}
{"X":2862,"KEGG":"R03279","RHEA_ID":18144,"DIRECTION":"BI","MASTER_ID":18141,"compounds":"NAD(+) + trans-cyclohexane-1,2-diol <=> 2-hydroxycyclohexan-1-one + H(+) + NADH","pmd":550.049}
{"X":2863,"KEGG":"R03279","RHEA_ID":18144,"DIRECTION":"BI","MASTER_ID":18141,"compounds":"NAD(+) + trans-cyclohexane-1,2-diol <=> 2-hydroxycyclohexan-1-one + H(+) + NADH","pmd":2.016}
{"X":2864,"KEGG":"R03281","RHEA_ID":10651,"DIRECTION":"BI","MASTER_ID":10648,"compounds":"2-hydroxycyclohexan-1-one + H(+) + NADPH + O2 <=> 6-hydroxyhexan-6-olide + H2O + NADP(+)","pmd":15.995}
{"X":2865,"KEGG":"R03281","RHEA_ID":10651,"DIRECTION":"BI","MASTER_ID":10648,"compounds":"2-hydroxycyclohexan-1-one + H(+) + NADPH + O2 <=> 6-hydroxyhexan-6-olide + H2O + NADP(+)","pmd":615.028}
{"X":2866,"KEGG":"R03283","RHEA_ID":17988,"DIRECTION":"BI","MASTER_ID":17985,"compounds":"4-(trimethylamino)butanal + H2O + NAD(+) <=> 4-(trimethylamino)butanoate + 2 H(+) + NADH","pmd":15.995}
{"X":2867,"KEGG":"R03283","RHEA_ID":17988,"DIRECTION":"BI","MASTER_ID":17985,"compounds":"4-(trimethylamino)butanal + H2O + NAD(+) <=> 4-(trimethylamino)butanoate + 2 H(+) + NADH","pmd":517.999}
{"X":2868,"KEGG":"R03288","RHEA_ID":59579,"DIRECTION":"BI","MASTER_ID":59576,"compounds":"anserine + H2O <=> beta-alanine + N(pros)-methyl-L-histidine","pmd":71.037}
{"X":2869,"KEGG":"R03289","RHEA_ID":21863,"DIRECTION":"BI","MASTER_ID":21860,"compounds":"3'-phosphoadenylyl sulfate + quercetin 3,3'-bissulfate <=> adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3',7-trissulfate","pmd":34.927}
{"X":2870,"KEGG":"R03295","RHEA_ID":52515,"DIRECTION":"BI","MASTER_ID":52512,"compounds":"a quinone + trans-4-hydroxy-L-proline <=> (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)","pmd":2.016}
{"X":2871,"KEGG":"R03296","RHEA_ID":21155,"DIRECTION":"BI","MASTER_ID":21152,"compounds":"trans-4-hydroxy-L-proline <=> cis-4-hydroxy-D-proline","pmd":0}
{"X":2872,"KEGG":"R03297","RHEA_ID":15252,"DIRECTION":"BI","MASTER_ID":15249,"compounds":"3,4,5-trihydroxybenzoate + UDP-alpha-D-glucose <=> 1-O-galloyl-beta-D-glucose + UDP","pmd":162.053}
{"X":2873,"KEGG":"R03298","RHEA_ID":42415,"DIRECTION":"BI","MASTER_ID":42412,"compounds":"(2R)-2,3-bisphosphoglycerate + ATP + H(+) <=> ADP + cyclic (2R)-2,3-bisphosphoglycerate + phosphate","pmd":79.966}
{"X":2874,"KEGG":"R03298","RHEA_ID":42415,"DIRECTION":"BI","MASTER_ID":42412,"compounds":"(2R)-2,3-bisphosphoglycerate + ATP + H(+) <=> ADP + cyclic (2R)-2,3-bisphosphoglycerate + phosphate","pmd":18.011}
{"X":2875,"KEGG":"R03303","RHEA_ID":15636,"DIRECTION":"BI","MASTER_ID":15633,"compounds":"3,4-dihydroxyphenylacetate + O2 <=> 2-hydroxy-5-carboxymethylmuconate semialdehyde + H(+)","pmd":31.99}
{"X":2876,"KEGG":"R03306","RHEA_ID":14692,"DIRECTION":"BI","MASTER_ID":14689,"compounds":"4-chlorophenylacetate + NADH + O2 <=> 3,4-dihydroxyphenylacetate + chloride + NAD(+)","pmd":1.971}
{"X":2877,"KEGG":"R03306","RHEA_ID":14692,"DIRECTION":"BI","MASTER_ID":14689,"compounds":"4-chlorophenylacetate + NADH + O2 <=> 3,4-dihydroxyphenylacetate + chloride + NAD(+)","pmd":497.083}
{"X":2878,"KEGG":"R03307","RHEA_ID":23659,"DIRECTION":"BI","MASTER_ID":23656,"compounds":"2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate <=> 3-carboxy-cis,cis-muconate + H(+)","pmd":0}
{"X":2879,"KEGG":"R03308","RHEA_ID":14980,"DIRECTION":"BI","MASTER_ID":14977,"metacyc":"CARBOXY-CISCIS-MUCONATE-CYCLASE-RXN","compounds":"3-carboxy-2,5-dihydro-5-oxofuran-2-acetate <=> 3-carboxy-cis,cis-muconate","pmd":0}
{"X":2880,"KEGG":"R03310","RHEA_ID":18924,"DIRECTION":"BI","MASTER_ID":18921,"compounds":"5alpha-cholest-7-en-3beta-ol + H(+) + NADH + O2 <=> cholesta-5,7-dien-3beta-ol + 2 H2O + NAD(+)"}
{"X":2881,"KEGG":"R03311","RHEA_ID":36414,"DIRECTION":"BI","MASTER_ID":36411,"compounds":"cholesta-5,7-dien-3beta-ol + hnu <=> calciol","pmd":0}
{"X":2882,"KEGG":"R03313","RHEA_ID":19544,"DIRECTION":"BI","MASTER_ID":19541,"compounds":"L-glutamate 5-semialdehyde + NADP(+) + phosphate <=> H(+) + L-glutamyl 5-phosphate + NADPH","pmd":517.064}
{"X":2883,"KEGG":"R03313","RHEA_ID":19544,"DIRECTION":"BI","MASTER_ID":19541,"compounds":"L-glutamate 5-semialdehyde + NADP(+) + phosphate <=> H(+) + L-glutamyl 5-phosphate + NADPH","pmd":95.961}
{"X":2884,"KEGG":"R03314","RHEA_ID":28237,"DIRECTION":"BI","MASTER_ID":28234,"ecocyc":"SPONTPRO-RXN","metacyc":"SPONTPRO-RXN","compounds":"L-glutamate 5-semialdehyde <=> (S)-1-pyrroline-5-carboxylate + H(+) + H2O","pmd":18.01}
{"X":2885,"KEGG":"R03315","RHEA_ID":22451,"DIRECTION":"BI","MASTER_ID":22448,"compounds":"ATP + pseudouridine <=> ADP + H(+) + psi-UMP","pmd":79.966}
{"X":2886,"KEGG":"R03317","RHEA_ID":25783,"DIRECTION":"BI","MASTER_ID":25780,"ecocyc":"UDPMANNACADEHYDROG-RXN","metacyc":"UDPMANNACADEHYDROG-RXN","compounds":"H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-mannosamine <=> 3 H(+) + 2 NADH + UDP-N-acetyl-alpha-D-mannosaminouronate","pmd":43.056}
{"X":2887,"KEGG":"R03317","RHEA_ID":25783,"DIRECTION":"BI","MASTER_ID":25780,"ecocyc":"UDPMANNACADEHYDROG-RXN","metacyc":"UDPMANNACADEHYDROG-RXN","compounds":"H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-mannosamine <=> 3 H(+) + 2 NADH + UDP-N-acetyl-alpha-D-mannosaminouronate","pmd":13.979}
{"X":2888,"KEGG":"R03323","RHEA_ID":12628,"DIRECTION":"BI","MASTER_ID":12625,"compounds":"(S)-malate + 1-O-(trans-sinapoyl)-beta-D-glucose <=> D-glucose + sinapoyl (S)-malate","pmd":46.042}
{"X":2889,"KEGG":"R03325","RHEA_ID":15860,"DIRECTION":"BI","MASTER_ID":15857,"metacyc":"1.1.1.149-RXN","compounds":"17alpha,20alpha-dihydroxypregn-4-en-3-one + NADP(+) <=> 17alpha-hydroxyprogesterone + H(+) + NADPH","pmd":2.016}
{"X":2890,"KEGG":"R03325","RHEA_ID":15860,"DIRECTION":"BI","MASTER_ID":15857,"metacyc":"1.1.1.149-RXN","compounds":"17alpha,20alpha-dihydroxypregn-4-en-3-one + NADP(+) <=> 17alpha-hydroxyprogesterone + H(+) + NADPH","pmd":413.864}
{"X":2891,"KEGG":"R03331","RHEA_ID":14036,"DIRECTION":"BI","MASTER_ID":14033,"compounds":"H2O + sn-glycero-3-phospho-1D-myo-inositol <=> 1D-myo-inositol 1-phosphate + glycerol + H(+)","pmd":74.037}
{"X":2892,"KEGG":"R03334","RHEA_ID":24359,"DIRECTION":"BI","MASTER_ID":24356,"compounds":"a 1-acyl-sn-glycero-3-phosphocholine <=> a 2-acyl-sn-glycero-3-phosphocholine"}
{"X":2893,"KEGG":"R03337","RHEA_ID":10783,"DIRECTION":"BI","MASTER_ID":10780,"compounds":"(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+) <=> 3-(4-hydroxyphenyl)pyruvate + H(+) + NADH","pmd":2.016}
{"X":2894,"KEGG":"R03337","RHEA_ID":10783,"DIRECTION":"BI","MASTER_ID":10780,"compounds":"(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+) <=> 3-(4-hydroxyphenyl)pyruvate + H(+) + NADH","pmd":484.075}
{"X":2895,"KEGG":"R03339","RHEA_ID":10779,"DIRECTION":"BI","MASTER_ID":10776,"compounds":"(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NADP(+) <=> 3-(4-hydroxyphenyl)pyruvate + H(+) + NADPH","pmd":564.041}
{"X":2896,"KEGG":"R03339","RHEA_ID":10779,"DIRECTION":"BI","MASTER_ID":10776,"compounds":"(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NADP(+) <=> 3-(4-hydroxyphenyl)pyruvate + H(+) + NADPH","pmd":2.016}
{"X":2897,"KEGG":"R03341","RHEA_ID":18700,"DIRECTION":"BI","MASTER_ID":18697,"compounds":"3-(4-hydroxyphenyl)pyruvate + H(+) <=> (4-hydroxyphenyl)acetaldehyde + CO2","pmd":43.99}
{"X":2898,"KEGG":"R03344","RHEA_ID":24471,"DIRECTION":"BI","MASTER_ID":24468,"compounds":"H(+) + N,N-dimethylaniline + NADPH + O2 <=> H2O + N,N-dimethylaniline N-oxide + NADP(+)","pmd":608.007}
{"X":2899,"KEGG":"R03344","RHEA_ID":24471,"DIRECTION":"BI","MASTER_ID":24468,"compounds":"H(+) + N,N-dimethylaniline + NADPH + O2 <=> H2O + N,N-dimethylaniline N-oxide + NADP(+)","pmd":15.995}
{"X":2900,"KEGG":"R03345","RHEA_ID":19324,"DIRECTION":"BI","MASTER_ID":19321,"compounds":"N,N-dimethylaniline N-oxide <=> formaldehyde + N-methylaniline","pmd":30.011}
{"X":2901,"KEGG":"R03346","RHEA_ID":30938,"DIRECTION":"BI","MASTER_ID":30935,"compounds":"H2O + nicotinate beta-D-ribonucleotide <=> beta-D-ribosylnicotinate + phosphate","pmd":79.966}
{"X":2902,"KEGG":"R03347","RHEA_ID":25571,"DIRECTION":"BI","MASTER_ID":25568,"compounds":"ATP + beta-D-ribosylnicotinate <=> ADP + H(+) + nicotinate beta-D-ribonucleotide","pmd":79.966}
{"X":2903,"KEGG":"R03348","RHEA_ID":12736,"DIRECTION":"BI","MASTER_ID":12733,"compounds":"CO2 + diphosphate + nicotinate beta-D-ribonucleotide <=> 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate","pmd":53.903}
{"X":2904,"KEGG":"R03349","RHEA_ID":19636,"DIRECTION":"BI","MASTER_ID":19633,"compounds":"(3S,5S)-3,5-diaminohexanoate + H2O + NAD(+) <=> (5S)-5-amino-3-oxo-hexanoate + H(+) + NADH + NH4(+)","pmd":1.032}
{"X":2905,"KEGG":"R03349","RHEA_ID":19636,"DIRECTION":"BI","MASTER_ID":19633,"compounds":"(3S,5S)-3,5-diaminohexanoate + H2O + NAD(+) <=> (5S)-5-amino-3-oxo-hexanoate + H(+) + NADH + NH4(+)","pmd":519.043}
{"X":2906,"KEGG":"R03350","RHEA_ID":11503,"DIRECTION":"BI","MASTER_ID":11500,"compounds":"3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + H2O <=> 3-deoxy-alpha-D-manno-oct-2-ulosonate + phosphate","pmd":79.966}
{"X":2907,"KEGG":"R03351","RHEA_ID":23451,"DIRECTION":"BI","MASTER_ID":23448,"compounds":"3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP <=> CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate","pmd":305.041}
{"X":2908,"KEGG":"R03351","RHEA_ID":23451,"DIRECTION":"BI","MASTER_ID":23448,"compounds":"3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP <=> CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate","pmd":60.126}
{"X":2909,"KEGG":"R03352","RHEA_ID":20891,"DIRECTION":"BI","MASTER_ID":20888,"compounds":"3-hydroxy-2-methylpropanoyl-CoA + H2O <=> 3-hydroxy-2-methylpropanoate + CoA + H(+)","pmd":86.037}
{"X":2910,"KEGG":"R03353","RHEA_ID":15284,"DIRECTION":"BI","MASTER_ID":15281,"compounds":"5alpha-cholest-7-en-3beta-ol <=> 5alpha-cholest-8-en-3beta-ol","pmd":0}
{"X":2911,"KEGG":"R03354","RHEA_ID":31498,"DIRECTION":"BI","MASTER_ID":31495,"metacyc":"RXN-12119","compounds":"a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose <=> a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP","pmd":162.053}
{"X":2912,"KEGG":"R03356","RHEA_ID":18364,"DIRECTION":"BI","MASTER_ID":18361,"metacyc":"2.4.2.33-RXN","compounds":"dolichyl D-xylosyl phosphate + L-seryl-[protein] <=> 3-O-(beta-D-xylosyl)-L-seryl-[protein] + dolichyl phosphate + H(+)"}
{"X":2913,"KEGG":"R03357","RHEA_ID":17344,"DIRECTION":"BI","MASTER_ID":17341,"metacyc":"ACYLGLYCERONE-PHOSPHATE-REDUCTASE-RXN","compounds":"1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) <=> 1-hexadecanoylglycerone 3-phosphate + H(+) + NADPH","pmd":2.016}
{"X":2914,"KEGG":"R03357","RHEA_ID":17344,"DIRECTION":"BI","MASTER_ID":17341,"metacyc":"ACYLGLYCERONE-PHOSPHATE-REDUCTASE-RXN","compounds":"1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) <=> 1-hexadecanoylglycerone 3-phosphate + H(+) + NADPH","pmd":335.856}
{"X":2915,"KEGG":"R03358","RHEA_ID":18176,"DIRECTION":"BI","MASTER_ID":18173,"compounds":"(2R)-1-(4-hydroxyphenyl)-2-aminoethanol <=> (4-hydroxyphenyl)acetaldehyde + NH4(+)","pmd":17.027}
{"X":2916,"KEGG":"R03359","RHEA_ID":32206,"DIRECTION":"BI","MASTER_ID":32203,"compounds":"(R)-synephrine <=> (4-hydroxyphenyl)acetaldehyde + methylamine","pmd":31.042}
{"X":2917,"KEGG":"R03360","RHEA_ID":18004,"DIRECTION":"BI","MASTER_ID":18001,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a carboxylate + H(+)"}
{"X":2918,"KEGG":"R03361","RHEA_ID":19880,"DIRECTION":"BI","MASTER_ID":19877,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP <=> 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)","pmd":79.966}
{"X":2919,"KEGG":"R03362","RHEA_ID":12712,"DIRECTION":"BI","MASTER_ID":12709,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)","pmd":79.966}
{"X":2920,"KEGG":"R03363","RHEA_ID":12319,"DIRECTION":"BI","MASTER_ID":12316,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}
{"X":2921,"KEGG":"R03364","RHEA_ID":17096,"DIRECTION":"BI","MASTER_ID":17093,"metacyc":"3.1.4.10-RXN","compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol"}
{"X":2922,"KEGG":"R03365","RHEA_ID":22219,"DIRECTION":"BI","MASTER_ID":22216,"compounds":"(E)-caffeate + O2 <=> 3-(2-carboxyethenyl)-cis,cis-muconate + 2 H(+)","pmd":31.99}
{"X":2923,"KEGG":"R03366","RHEA_ID":20228,"DIRECTION":"BI","MASTER_ID":20225,"compounds":"(E)-caffeate + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + trans-ferulate","pmd":14.016}
{"X":2924,"KEGG":"R03369","RHEA_ID":17672,"DIRECTION":"BI","MASTER_ID":17669,"compounds":"3-(2-hydroxyphenyl)propanoate + H(+) + NADH + O2 <=> 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+)","pmd":15.995}
{"X":2925,"KEGG":"R03369","RHEA_ID":17672,"DIRECTION":"BI","MASTER_ID":17669,"compounds":"3-(2-hydroxyphenyl)propanoate + H(+) + NADH + O2 <=> 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+)","pmd":483.067}
{"X":2926,"KEGG":"R03370","RHEA_ID":11779,"DIRECTION":"BI","MASTER_ID":11776,"compounds":"2 H(+) + O2 + octadecanoyl-[ACP] + 2 reduced [2Fe-2S]-[ferredoxin] <=> (9Z)-octadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":2927,"KEGG":"R03371","RHEA_ID":16992,"DIRECTION":"BI","MASTER_ID":16989,"compounds":"1D-myo-inositol hexakisphosphate + H2O <=> 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate","pmd":79.966}
{"X":2928,"KEGG":"R03372","RHEA_ID":20963,"DIRECTION":"BI","MASTER_ID":20960,"metacyc":"RXN-10942","compounds":"1D-myo-inositol hexakisphosphate + H2O <=> 1D-myo-inositol 1,2,3,5,6-pentakisphosphate + phosphate","pmd":79.966}
{"X":2929,"KEGG":"R03373","RHEA_ID":57411,"DIRECTION":"BI","MASTER_ID":57408,"compounds":"(2R)-3-(3,4-dihydroxyphenyl)lactate + NAD(+) <=> 3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADH","pmd":468.08}
{"X":2930,"KEGG":"R03373","RHEA_ID":57411,"DIRECTION":"BI","MASTER_ID":57408,"compounds":"(2R)-3-(3,4-dihydroxyphenyl)lactate + NAD(+) <=> 3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADH","pmd":2.016}
{"X":2931,"KEGG":"R03374","RHEA_ID":22347,"DIRECTION":"BI","MASTER_ID":22344,"compounds":"(2R)-3-(3,4-dihydroxyphenyl)lactate + caffeoyl-CoA <=> (R)-rosmarinate + CoA","pmd":162.032}
{"X":2932,"KEGG":"R03375","RHEA_ID":10579,"DIRECTION":"BI","MASTER_ID":10576,"compounds":"CTP + H(+) + N-methylethanolamine phosphate <=> CDP-N-methylethanolamine + diphosphate","pmd":305.041}
{"X":2933,"KEGG":"R03375","RHEA_ID":10579,"DIRECTION":"BI","MASTER_ID":10576,"compounds":"CTP + H(+) + N-methylethanolamine phosphate <=> CDP-N-methylethanolamine + diphosphate","pmd":22.909}
{"X":2934,"KEGG":"R03376","RHEA_ID":16572,"DIRECTION":"BI","MASTER_ID":16569,"compounds":"2-oxoglutarate + L-lysyl-[procollagen] + O2 <=> (5R)-5-hydroxy-L-lysyl-[procollagen] + CO2 + succinate","pmd":27.995}
{"X":2935,"KEGG":"R03378","RHEA_ID":19052,"DIRECTION":"BI","MASTER_ID":19049,"metacyc":"HYDROXYLYSINE-KINASE-RXN","compounds":"(5R)-5-hydroxy-L-lysine + GTP <=> (5R)-5-phosphooxy-L-lysine + GDP + H(+)","pmd":79.966}
{"X":2936,"KEGG":"R03380","RHEA_ID":12640,"DIRECTION":"BI","MASTER_ID":12637,"metacyc":"PROCOLLAGEN-GALACTOSYLTRANSFERASE-RXN","compounds":"(5R)-5-hydroxy-L-lysyl-[procollagen] + UDP-alpha-D-galactose <=> (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[procollagen] + H(+) + UDP","pmd":162.053}
{"X":2937,"KEGG":"R03384","RHEA_ID":18608,"DIRECTION":"BI","MASTER_ID":18605,"compounds":"1-amino-1-deoxy-scyllo-inositol + ATP <=> 1-amino-1-deoxy-scyllo-inositol 4-phosphate + ADP + H(+)","pmd":79.966}
{"X":2938,"KEGG":"R03385","RHEA_ID":10863,"DIRECTION":"BI","MASTER_ID":10860,"compounds":"3-hydroxy-2-methylpyridine-5-carboxylate + NADH + O2 <=> 2-(acetamidomethylene)succinate + NAD(+)","pmd":478.077}
{"X":2939,"KEGG":"R03385","RHEA_ID":10863,"DIRECTION":"BI","MASTER_ID":10860,"compounds":"3-hydroxy-2-methylpyridine-5-carboxylate + NADH + O2 <=> 2-(acetamidomethylene)succinate + NAD(+)","pmd":34.006}
{"X":2940,"KEGG":"R03386","RHEA_ID":10867,"DIRECTION":"BI","MASTER_ID":10864,"compounds":"3-hydroxy-2-methylpyridine-5-carboxylate + NADPH + O2 <=> 2-(acetamidomethylene)succinate + NADP(+)","pmd":558.043}
{"X":2941,"KEGG":"R03386","RHEA_ID":10867,"DIRECTION":"BI","MASTER_ID":10864,"compounds":"3-hydroxy-2-methylpyridine-5-carboxylate + NADPH + O2 <=> 2-(acetamidomethylene)succinate + NADP(+)","pmd":34.006}
{"X":2942,"KEGG":"R03387","RHEA_ID":16528,"DIRECTION":"BI","MASTER_ID":16525,"compounds":"2-dehydro-3-deoxy-D-galactonate + ATP <=> 2-dehydro-3-deoxy-6-phospho-D-galactonate + ADP + H(+)","pmd":79.966}
{"X":2943,"KEGG":"R03388","RHEA_ID":35822,"DIRECTION":"BI","MASTER_ID":35819,"metacyc":"RXN-10029","compounds":"5,6,7,8-tetrahydromethanopterin + NADP(+) <=> 7,8-dihydromethanopterin + H(+) + NADPH","pmd":30.164}
{"X":2944,"KEGG":"R03388","RHEA_ID":35822,"DIRECTION":"BI","MASTER_ID":35819,"metacyc":"RXN-10029","compounds":"5,6,7,8-tetrahydromethanopterin + NADP(+) <=> 7,8-dihydromethanopterin + H(+) + NADPH","pmd":2.016}
{"X":2945,"KEGG":"R03390","RHEA_ID":18064,"DIRECTION":"BI","MASTER_ID":18061,"compounds":"5,6,7,8-tetrahydromethanopterin + H(+) + N-formylmethanofuran <=> methanofuran + N(5)-formyl-5,6,7,8-tetrahydromethanopterin","pmd":27.983}
{"X":2946,"KEGG":"R03391","RHEA_ID":19656,"DIRECTION":"BI","MASTER_ID":19653,"compounds":"CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NAD(+) <=> CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH","pmd":15.995}
{"X":2947,"KEGG":"R03391","RHEA_ID":19656,"DIRECTION":"BI","MASTER_ID":19653,"compounds":"CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NAD(+) <=> CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH","pmd":117.057}
{"X":2948,"KEGG":"R03392","RHEA_ID":19660,"DIRECTION":"BI","MASTER_ID":19657,"compounds":"CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NADP(+) <=> CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH","pmd":15.995}
{"X":2949,"KEGG":"R03392","RHEA_ID":19660,"DIRECTION":"BI","MASTER_ID":19657,"compounds":"CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NADP(+) <=> CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH","pmd":197.023}
{"X":2950,"KEGG":"R03393","RHEA_ID":15556,"DIRECTION":"BI","MASTER_ID":15553,"compounds":"1D-myo-inositol 1,4-bisphosphate + H2O <=> 1D-myo-inositol 4-phosphate + phosphate","pmd":79.966}
{"X":2951,"KEGG":"R03394","RHEA_ID":19800,"DIRECTION":"BI","MASTER_ID":19797,"compounds":"1D-myo-inositol 1,4,5-trisphosphate + H2O <=> 1D-myo-inositol 1,4-bisphosphate + phosphate","pmd":79.966}
{"X":2952,"KEGG":"R03395","RHEA_ID":16284,"DIRECTION":"BI","MASTER_ID":16281,"compounds":"ATP + dihydrostreptomycin 6-phosphate <=> ADP + dihydrostreptomycin 3'alpha,6-bisphosphate + H(+)","pmd":79.966}
{"X":2953,"KEGG":"R03396","RHEA_ID":10731,"DIRECTION":"BI","MASTER_ID":10728,"compounds":"GDP-6-deoxy-alpha-D-talose + NAD(+) <=> GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH","pmd":2.016}
{"X":2954,"KEGG":"R03396","RHEA_ID":10731,"DIRECTION":"BI","MASTER_ID":10728,"compounds":"GDP-6-deoxy-alpha-D-talose + NAD(+) <=> GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH","pmd":77.05}
{"X":2955,"KEGG":"R03397","RHEA_ID":13828,"DIRECTION":"BI","MASTER_ID":13825,"compounds":"GDP-alpha-D-rhamnose + NAD(+) <=> GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH","pmd":77.05}
{"X":2956,"KEGG":"R03397","RHEA_ID":13828,"DIRECTION":"BI","MASTER_ID":13825,"compounds":"GDP-alpha-D-rhamnose + NAD(+) <=> GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH","pmd":2.016}
{"X":2957,"KEGG":"R03398","RHEA_ID":10727,"DIRECTION":"BI","MASTER_ID":10724,"compounds":"GDP-6-deoxy-alpha-D-talose + NADP(+) <=> GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH","pmd":2.016}
{"X":2958,"KEGG":"R03398","RHEA_ID":10727,"DIRECTION":"BI","MASTER_ID":10724,"compounds":"GDP-6-deoxy-alpha-D-talose + NADP(+) <=> GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH","pmd":157.017}
{"X":2959,"KEGG":"R03399","RHEA_ID":13832,"DIRECTION":"BI","MASTER_ID":13829,"compounds":"GDP-alpha-D-rhamnose + NADP(+) <=> GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH","pmd":157.017}
{"X":2960,"KEGG":"R03399","RHEA_ID":13832,"DIRECTION":"BI","MASTER_ID":13829,"compounds":"GDP-alpha-D-rhamnose + NADP(+) <=> GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH","pmd":2.016}
{"X":2961,"KEGG":"R03401","RHEA_ID":21891,"DIRECTION":"BI","MASTER_ID":21888,"compounds":"NADP(+) + OPC-8 <=> (10Z,15Z)-12-oxophytodienoate + H(+) + NADPH","pmd":2.016}
{"X":2962,"KEGG":"R03401","RHEA_ID":21891,"DIRECTION":"BI","MASTER_ID":21888,"compounds":"NADP(+) + OPC-8 <=> (10Z,15Z)-12-oxophytodienoate + H(+) + NADPH","pmd":451.88}
{"X":2963,"KEGG":"R03402","RHEA_ID":22595,"DIRECTION":"BI","MASTER_ID":22592,"compounds":"(9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate <=> (10Z,15Z)-12-oxophytodienoate","pmd":0}
{"X":2964,"KEGG":"R03404","RHEA_ID":19876,"DIRECTION":"BI","MASTER_ID":19873,"compounds":"3beta-sulfooxy-androst-5-en-17-one + H2O <=> 3beta-hydroxyandrost-5-en-17-one + H(+) + sulfate","pmd":79.957}
{"X":2965,"KEGG":"R03409","RHEA_ID":13076,"DIRECTION":"BI","MASTER_ID":13073,"compounds":"guanosine 3'-diphosphate 5'-triphosphate + H2O <=> guanosine 3',5'-bis(diphosphate) + H(+) + phosphate","pmd":79.966}
{"X":2966,"KEGG":"R03410","RHEA_ID":14812,"DIRECTION":"BI","MASTER_ID":14809,"compounds":"phenol + S-adenosyl-L-methionine <=> anisole + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":2967,"KEGG":"R03410","RHEA_ID":17552,"DIRECTION":"BI","MASTER_ID":17549,"compounds":"1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine <=> 1-acyl-2-(10-methylene)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":2968,"KEGG":"R03411","RHEA_ID":11991,"DIRECTION":"BI","MASTER_ID":11988,"compounds":"1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine <=> 1-acyl-2-(9-cyclopronane)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":2969,"KEGG":"R03415","RHEA_ID":16908,"DIRECTION":"BI","MASTER_ID":16905,"metacyc":"3.3.2.5-RXN","compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O <=> a 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine"}
{"X":2970,"KEGG":"R03415","RHEA_ID":22327,"DIRECTION":"BI","MASTER_ID":22324,"compounds":"H2O + leukotriene A4 <=> leukotriene B4"}
{"X":2971,"KEGG":"R03418","RHEA_ID":20779,"DIRECTION":"BI","MASTER_ID":20776,"metacyc":"2.4.1.67-RXN","compounds":"alpha-D-galactosyl-(1->3)-1D-myo-inositol + raffinose <=> myo-inositol + stachyose","pmd":162.053}
{"X":2972,"KEGG":"R03421","RHEA_ID":11547,"DIRECTION":"BI","MASTER_ID":11544,"compounds":"H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine <=> H(+) + L-aspartate + N-acetyl-beta-D-glucosaminylamine","pmd":115.027}
{"X":2973,"KEGG":"R03422","RHEA_ID":14492,"DIRECTION":"BI","MASTER_ID":14489,"compounds":"a nucleoside 2',3'-cyclic phosphate + H2O <=> a nucleoside 2'-phosphate + H(+)"}
{"X":2974,"KEGG":"R03423","RHEA_ID":19624,"DIRECTION":"BI","MASTER_ID":19621,"compounds":"a nucleoside 2',3'-cyclic phosphate + H2O <=> a nucleoside 3'-phosphate + H(+)"}
{"X":2975,"KEGG":"R03424","RHEA_ID":32738,"DIRECTION":"BI","MASTER_ID":32735,"compounds":"1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine <=> 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":2976,"KEGG":"R03425","RHEA_ID":24307,"DIRECTION":"BI","MASTER_ID":24304,"ecocyc":"GCVP-RXN","metacyc":"GCVP-RXN","compounds":"glycine + H(+) + N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] <=> (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2"}
{"X":2977,"KEGG":"R03428","RHEA_ID":13256,"DIRECTION":"BI","MASTER_ID":13253,"compounds":"1D-myo-inositol 1,3,4-trisphosphate + ATP <=> 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)","pmd":7.067}
{"X":2978,"KEGG":"R03429","RHEA_ID":20943,"DIRECTION":"BI","MASTER_ID":20940,"compounds":"1D-myo-inositol 1,3,4-trisphosphate + ATP <=> 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)","pmd":7.067}
{"X":2979,"KEGG":"R03430","RHEA_ID":11395,"DIRECTION":"BI","MASTER_ID":11392,"compounds":"1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O <=> 1D-myo-inositol 1,3,4-trisphosphate + phosphate","pmd":79.966}
{"X":2980,"KEGG":"R03431","RHEA_ID":20296,"DIRECTION":"BI","MASTER_ID":20293,"metacyc":"DIIODOPHENYLPYRUVATE-REDUCTASE-RXN","compounds":"3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD(+) <=> 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H(+) + NADH","pmd":232.281}
{"X":2981,"KEGG":"R03431","RHEA_ID":20296,"DIRECTION":"BI","MASTER_ID":20293,"metacyc":"DIIODOPHENYLPYRUVATE-REDUCTASE-RXN","compounds":"3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD(+) <=> 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H(+) + NADH","pmd":2.016}
{"X":2982,"KEGG":"R03433","RHEA_ID":11023,"DIRECTION":"BI","MASTER_ID":11020,"compounds":"1D-myo-inositol 1,4,5-trisphosphate + ATP <=> 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)","pmd":7.067}
{"X":2983,"KEGG":"R03435","RHEA_ID":33182,"DIRECTION":"BI","MASTER_ID":33179,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O <=> 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)"}
{"X":2984,"KEGG":"R03437","RHEA_ID":18464,"DIRECTION":"BI","MASTER_ID":18461,"metacyc":"2.3.1.67-RXN","compounds":"1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA <=> 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA","pmd":42.011}
{"X":2985,"KEGG":"R03438","RHEA_ID":23995,"DIRECTION":"BI","MASTER_ID":23992,"compounds":"1-O-alkyl-sn-glycero-3-phosphocholine + an acyl-CoA <=> 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA"}
{"X":2986,"KEGG":"R03441","RHEA_ID":11971,"DIRECTION":"BI","MASTER_ID":11968,"compounds":"AH2 + kynurenate + O2 <=> 7,8-dihydro-7,8-dihydroxykynurenate + A","pmd":34.006}
{"X":2987,"KEGG":"R03443","RHEA_ID":21591,"DIRECTION":"BI","MASTER_ID":21588,"ecocyc":"N-ACETYLGLUTPREDUCT-RXN","metacyc":"N-ACETYLGLUTPREDUCT-RXN","compounds":"N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate <=> H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH","pmd":95.961}
{"X":2988,"KEGG":"R03443","RHEA_ID":21591,"DIRECTION":"BI","MASTER_ID":21588,"ecocyc":"N-ACETYLGLUTPREDUCT-RXN","metacyc":"N-ACETYLGLUTPREDUCT-RXN","compounds":"N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate <=> H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH","pmd":475.053}
{"X":2989,"KEGG":"R03444","RHEA_ID":26104,"DIRECTION":"BI","MASTER_ID":26101,"compounds":"(2R)-homocitrate <=> cis-homoaconitate + H2O","pmd":18.011}
{"X":2990,"KEGG":"R03445","RHEA_ID":42455,"DIRECTION":"BI","MASTER_ID":42452,"compounds":"4-(2-aminophenyl)-2,4-dioxobutanoate <=> H2O + kynurenate","pmd":18.011}
{"X":2991,"KEGG":"R03446","RHEA_ID":14496,"DIRECTION":"BI","MASTER_ID":14493,"metacyc":"3.2.2.24-RXN","compounds":"H2O + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] <=> ADP-D-ribose + L-arginyl-[dinitrogen reductase]"}
{"X":2992,"KEGG":"R03447","RHEA_ID":18080,"DIRECTION":"BI","MASTER_ID":18077,"metacyc":"2.4.2.37-RXN","compounds":"L-arginyl-[dinitrogen reductase] + NAD(+) <=> H(+) + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] + nicotinamide","pmd":542.069}
{"X":2993,"KEGG":"R03448","RHEA_ID":16228,"DIRECTION":"BI","MASTER_ID":16225,"compounds":"1,8-diazacyclotetradecane-2,9-dione + H2O <=> N-(6-aminohexanoyl)-6-aminohexanoate","pmd":18.011}
{"X":2994,"KEGG":"R03449","RHEA_ID":23055,"DIRECTION":"BI","MASTER_ID":23052,"compounds":"[pyruvate dehydrogenase E1 alpha subunit]-L-serine + ATP <=> [pyruvate dehydrogenase E1 alpha subunit]-O-phospho-L-serine + ADP + H(+)","pmd":79.966}
{"X":2995,"KEGG":"R03450","RHEA_ID":12672,"DIRECTION":"BI","MASTER_ID":12669,"compounds":"[pyruvate dehydrogenase E1 alpha subunit]-O-phospho-L-serine + H2O <=> [pyruvate dehydrogenase E1 alpha subunit]-L-serine + phosphate"}
{"X":2996,"KEGG":"R03451","RHEA_ID":14184,"DIRECTION":"BI","MASTER_ID":14181,"compounds":"2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O2 <=> (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO2 + succinate","pmd":27.995}
{"X":2997,"KEGG":"R03451","RHEA_ID":14184,"DIRECTION":"BI","MASTER_ID":14181,"compounds":"2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O2 <=> (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO2 + succinate","pmd":17.003}
{"X":2998,"KEGG":"R03452","RHEA_ID":15324,"DIRECTION":"BI","MASTER_ID":15321,"compounds":"(6aR,11aR)-3,9-dihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] <=> (6aS,11aS)-3,6a,9-trihydroxypterocarpan + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":2999,"KEGG":"R03454","RHEA_ID":18224,"DIRECTION":"BI","MASTER_ID":18221,"compounds":"1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + H2O <=> a 1-O-alkyl-2-acetyl-sn-glycerol + phosphate"}
{"X":3000,"KEGG":"R03455","RHEA_ID":18560,"DIRECTION":"BI","MASTER_ID":18557,"compounds":"1-O-alkyl-sn-glycero-3-phosphate + acetyl-CoA <=> 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA","pmd":42.011}
{"X":3001,"KEGG":"R03456","RHEA_ID":21835,"DIRECTION":"BI","MASTER_ID":21832,"compounds":"3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine <=> 3',5-dihydroxy-3,4',7-trimethoxyflavone + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":3002,"KEGG":"R03457","RHEA_ID":11043,"DIRECTION":"BI","MASTER_ID":11040,"compounds":"D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate <=> 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O","pmd":18.011}
{"X":3003,"KEGG":"R03458","RHEA_ID":17848,"DIRECTION":"BI","MASTER_ID":17845,"compounds":"5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) <=> 5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH","pmd":390.026}
{"X":3004,"KEGG":"R03458","RHEA_ID":17848,"DIRECTION":"BI","MASTER_ID":17845,"compounds":"5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) <=> 5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH","pmd":2.016}
{"X":3005,"KEGG":"R03459","RHEA_ID":21871,"DIRECTION":"BI","MASTER_ID":21868,"compounds":"2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O <=> 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)","pmd":0.984}
{"X":3006,"KEGG":"R03460","RHEA_ID":21259,"DIRECTION":"BI","MASTER_ID":21256,"ecocyc":"2.5.1.19-RXN","metacyc":"2.5.1.19-RXN","compounds":"3-phosphoshikimate + phosphoenolpyruvate <=> 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate","pmd":70.005}
{"X":3007,"KEGG":"R03460","RHEA_ID":21259,"DIRECTION":"BI","MASTER_ID":21256,"ecocyc":"2.5.1.19-RXN","metacyc":"2.5.1.19-RXN","compounds":"3-phosphoshikimate + phosphoenolpyruvate <=> 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate","pmd":156.042}
{"X":3008,"KEGG":"R03461","RHEA_ID":13672,"DIRECTION":"BI","MASTER_ID":13669,"compounds":"5-hydroxy-6-methylpyridine-3,4-dicarboxylate + H(+) <=> 3-hydroxy-2-methylpyridine-5-carboxylate + CO2","pmd":43.99}
{"X":3009,"KEGG":"R03462","RHEA_ID":14416,"DIRECTION":"BI","MASTER_ID":14413,"compounds":"biphenyl-2,3-diol + O2 <=> 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+)","pmd":31.99}
{"X":3010,"KEGG":"R03463","RHEA_ID":24271,"DIRECTION":"BI","MASTER_ID":24268,"compounds":"2,6-dioxo-6-phenylhexanoate + NADP(+) <=> 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+) + NADPH","pmd":2.016}
{"X":3011,"KEGG":"R03463","RHEA_ID":24271,"DIRECTION":"BI","MASTER_ID":24268,"compounds":"2,6-dioxo-6-phenylhexanoate + NADP(+) <=> 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+) + NADPH","pmd":526.025}
{"X":3012,"KEGG":"R03464","RHEA_ID":19056,"DIRECTION":"BI","MASTER_ID":19053,"metacyc":"3.5.4.27-RXN","compounds":"5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O <=> H(+) + N(5)-formyl-5,6,7,8-tetrahydromethanopterin","pmd":17.003}
{"X":3013,"KEGG":"R03467","RHEA_ID":13192,"DIRECTION":"BI","MASTER_ID":13189,"compounds":"a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O <=> 3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+)"}
{"X":3014,"KEGG":"R03468","RHEA_ID":11667,"DIRECTION":"BI","MASTER_ID":11664,"compounds":"a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + CMP-N-acetyl-beta-neuraminate <=> 1,2-diacyl-3-[3-(N-acetyl-alpha-D-neuraminyl)-beta-D-galactosyl]-sn-glycerol + CMP + H(+)","pmd":291.095}
{"X":3015,"KEGG":"R03469","RHEA_ID":14428,"DIRECTION":"BI","MASTER_ID":14425,"compounds":"1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)","pmd":79.966}
{"X":3016,"KEGG":"R03470","RHEA_ID":23351,"DIRECTION":"BI","MASTER_ID":23348,"compounds":"(R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H(+) <=> (4,5-dihydro-5-oxofuran-2-yl)-acetate + CO2","pmd":43.99}
{"X":3017,"KEGG":"R03471","RHEA_ID":23099,"DIRECTION":"BI","MASTER_ID":23096,"compounds":"4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP <=> 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+)","pmd":79.966}
{"X":3018,"KEGG":"R03472","RHEA_ID":24843,"DIRECTION":"BI","MASTER_ID":24840,"compounds":"5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine <=> 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine","pmd":147.035}
{"X":3019,"KEGG":"R03472","RHEA_ID":24843,"DIRECTION":"BI","MASTER_ID":24840,"compounds":"5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine <=> 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine","pmd":43.955}
{"X":3020,"KEGG":"R03473","RHEA_ID":18592,"DIRECTION":"BI","MASTER_ID":18589,"compounds":"[glutamine synthetase]-L-tyrosine + ATP <=> [glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + diphosphate"}
{"X":3021,"KEGG":"R03474","RHEA_ID":43719,"DIRECTION":"BI","MASTER_ID":43716,"compounds":"[glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + phosphate <=> [glutamine synthetase]-L-tyrosine + ADP"}
{"X":3022,"KEGG":"R03475","RHEA_ID":12567,"DIRECTION":"BI","MASTER_ID":12564,"compounds":"1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + NAD(+) <=> 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H(+) + NADH"}
{"X":3023,"KEGG":"R03476","RHEA_ID":11371,"DIRECTION":"BI","MASTER_ID":11368,"compounds":"1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H(+) + NADH + O2 <=> 1-acyl-2-[(S)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + H2O + NAD(+)"}
{"X":3024,"KEGG":"R03477","RHEA_ID":13268,"DIRECTION":"BI","MASTER_ID":13265,"compounds":"1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine <=> 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithine","pmd":42.022}
{"X":3025,"KEGG":"R03478","RHEA_ID":12720,"DIRECTION":"BI","MASTER_ID":12717,"compounds":"1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP <=> 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)","pmd":72.899}
{"X":3026,"KEGG":"R03479","RHEA_ID":12455,"DIRECTION":"BI","MASTER_ID":12452,"compounds":"1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP <=> 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)","pmd":72.899}
{"X":3027,"KEGG":"R03482","RHEA_ID":11663,"DIRECTION":"BI","MASTER_ID":11660,"metacyc":"3.1.1.69-RXN","compounds":"a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O <=> a 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + acetate"}
{"X":3028,"KEGG":"R03486","RHEA_ID":11927,"DIRECTION":"BI","MASTER_ID":11924,"metacyc":"2.4.1.228-RXN","compounds":"a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose <=> globoside Gb3Cer (d18:1(4E)) + H(+) + UDP","pmd":162.053}
{"X":3029,"KEGG":"R03488","RHEA_ID":18420,"DIRECTION":"BI","MASTER_ID":18417,"metacyc":"2.4.99.9-RXN","compounds":"a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> CMP + ganglioside GM3 (d18:1(4E)) + H(+)","pmd":291.095}
{"X":3030,"KEGG":"R03489","RHEA_ID":21555,"DIRECTION":"BI","MASTER_ID":21552,"metacyc":"2.4.99.11-RXN","compounds":"a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide","pmd":291.095}
{"X":3031,"KEGG":"R03493","RHEA_ID":24147,"DIRECTION":"BI","MASTER_ID":24144,"compounds":"3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA <=> 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O","pmd":18.011}
{"X":3032,"KEGG":"R03494","RHEA_ID":17704,"DIRECTION":"BI","MASTER_ID":17701,"compounds":"ATP + geranoyl-CoA + hydrogencarbonate <=> 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + H(+) + phosphate","pmd":79.966}
{"X":3033,"KEGG":"R03494","RHEA_ID":17704,"DIRECTION":"BI","MASTER_ID":17701,"compounds":"ATP + geranoyl-CoA + hydrogencarbonate <=> 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + H(+) + phosphate","pmd":43.99}
{"X":3034,"KEGG":"R03495","RHEA_ID":21427,"DIRECTION":"BI","MASTER_ID":21424,"metacyc":"12-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN","compounds":"3alpha,7alpha,12beta-trihydroxy-5beta-cholanate + NADP(+) <=> 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH","pmd":337.811}
{"X":3035,"KEGG":"R03495","RHEA_ID":21427,"DIRECTION":"BI","MASTER_ID":21424,"metacyc":"12-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN","compounds":"3alpha,7alpha,12beta-trihydroxy-5beta-cholanate + NADP(+) <=> 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH","pmd":2.016}
{"X":3036,"KEGG":"R03496","RHEA_ID":15780,"DIRECTION":"BI","MASTER_ID":15777,"compounds":"1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O <=> 1-guanidino-1-deoxy-scyllo-inositol + phosphate","pmd":79.966}
{"X":3037,"KEGG":"R03497","RHEA_ID":11303,"DIRECTION":"BI","MASTER_ID":11300,"metacyc":"SEQUOYITOL-DEHYDROGENASE-RXN","compounds":"1D-5-O-methyl-myo-inositol + NAD(+) <=> 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADH","pmd":2.016}
{"X":3038,"KEGG":"R03497","RHEA_ID":11303,"DIRECTION":"BI","MASTER_ID":11300,"metacyc":"SEQUOYITOL-DEHYDROGENASE-RXN","compounds":"1D-5-O-methyl-myo-inositol + NAD(+) <=> 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADH","pmd":472.053}
{"X":3039,"KEGG":"R03498","RHEA_ID":20440,"DIRECTION":"BI","MASTER_ID":20437,"metacyc":"D-PINITOL-DEHYDROGENASE-RXN","compounds":"5D-5-O-methyl-chiro-inositol + NADP(+) <=> 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADPH","pmd":2.016}
{"X":3040,"KEGG":"R03498","RHEA_ID":20440,"DIRECTION":"BI","MASTER_ID":20437,"metacyc":"D-PINITOL-DEHYDROGENASE-RXN","compounds":"5D-5-O-methyl-chiro-inositol + NADP(+) <=> 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADPH","pmd":552.02}
{"X":3041,"KEGG":"R03502","RHEA_ID":15500,"DIRECTION":"BI","MASTER_ID":15497,"metacyc":"2.6.1.56-RXN","compounds":"1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate <=> 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine","pmd":1.032}
{"X":3042,"KEGG":"R03503","RHEA_ID":11415,"DIRECTION":"BI","MASTER_ID":11412,"compounds":"6-hydroxymethyl-7,8-dihydropterin + ATP <=> (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)","pmd":151.988}
{"X":3043,"KEGG":"R03503","RHEA_ID":11415,"DIRECTION":"BI","MASTER_ID":11412,"compounds":"6-hydroxymethyl-7,8-dihydropterin + ATP <=> (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)","pmd":151.987}
{"X":3044,"KEGG":"R03504","RHEA_ID":10543,"DIRECTION":"BI","MASTER_ID":10540,"compounds":"7,8-dihydroneopterin <=> 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde","pmd":60.021}
{"X":3045,"KEGG":"R03506","RHEA_ID":24587,"DIRECTION":"BI","MASTER_ID":24584,"compounds":"(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + H2O + NAD(+) <=> (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + 2 H(+) + NADH","pmd":15.995}
{"X":3046,"KEGG":"R03506","RHEA_ID":24587,"DIRECTION":"BI","MASTER_ID":24584,"compounds":"(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + H2O + NAD(+) <=> (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + 2 H(+) + NADH","pmd":213.782}
{"X":3047,"KEGG":"R03507","RHEA_ID":40234,"DIRECTION":"BI","MASTER_ID":40231,"compounds":"(25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + 2 H2O + 2 oxidized [adrenodoxin]","pmd":2.016}
{"X":3048,"KEGG":"R03508","RHEA_ID":23479,"DIRECTION":"BI","MASTER_ID":23476,"compounds":"1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) <=> (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O","pmd":62}
{"X":3049,"KEGG":"R03509","RHEA_ID":21543,"DIRECTION":"BI","MASTER_ID":21540,"compounds":"N-(5-phospho-beta-D-ribosyl)anthranilate <=> 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate","pmd":0}
{"X":3050,"KEGG":"R03510","RHEA_ID":16748,"DIRECTION":"BI","MASTER_ID":16745,"compounds":"AH2 + O2 + phylloquinone <=> 2,3-epoxyphylloquinone + A + H2O","pmd":15.995}
{"X":3051,"KEGG":"R03511","RHEA_ID":13820,"DIRECTION":"BI","MASTER_ID":13817,"compounds":"[protein]-disulfide + H2O + phylloquinone <=> 2,3-epoxyphylloquinone + [protein]-dithiol","pmd":15.995}
{"X":3052,"KEGG":"R03511","RHEA_ID":13820,"DIRECTION":"BI","MASTER_ID":13817,"compounds":"[protein]-disulfide + H2O + phylloquinone <=> 2,3-epoxyphylloquinone + [protein]-dithiol","pmd":2.016}
{"X":3053,"KEGG":"R03512","RHEA_ID":21563,"DIRECTION":"BI","MASTER_ID":21560,"compounds":"3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + oxidized dithiothreitol <=> 1,4-dithiothreitol + 2,3-epoxyphylloquinone","pmd":2.016}
{"X":3054,"KEGG":"R03516","RHEA_ID":17304,"DIRECTION":"BI","MASTER_ID":17301,"metacyc":"2.7.11.4-RXN","compounds":"[3-methyl-2-oxobutanoate dehydrogenase]-L-serine + ATP <=> [3-methyl-2-oxobutanoate dehydrogenase]-O-phospho-L-serine + ADP + H(+)","pmd":79.966}
{"X":3055,"KEGG":"R03517","RHEA_ID":11447,"DIRECTION":"BI","MASTER_ID":11444,"compounds":"4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 4-sulfate + H2O <=> 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate","pmd":79.957}
{"X":3056,"KEGG":"R03518","RHEA_ID":10539,"DIRECTION":"BI","MASTER_ID":10536,"compounds":"4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 6-sulfate + H2O <=> 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate","pmd":79.957}
{"X":3057,"KEGG":"R03519","RHEA_ID":14260,"DIRECTION":"BI","MASTER_ID":14257,"compounds":"a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose <=> a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)","pmd":146.058}
{"X":3058,"KEGG":"R03520","RHEA_ID":21423,"DIRECTION":"BI","MASTER_ID":21420,"compounds":"NADP(+) + prostaglandin I2 <=> 15-dehydro-prostaglandin I2 + H(+) + NADPH","pmd":393.874}
{"X":3059,"KEGG":"R03520","RHEA_ID":21423,"DIRECTION":"BI","MASTER_ID":21420,"compounds":"NADP(+) + prostaglandin I2 <=> 15-dehydro-prostaglandin I2 + H(+) + NADPH","pmd":2.016}
{"X":3060,"KEGG":"R03522","RHEA_ID":16440,"DIRECTION":"BI","MASTER_ID":16437,"compounds":"glutathione + RX <=> a halide anion + an S-substituted glutathione + H(+)"}
{"X":3061,"KEGG":"R03523","RHEA_ID":13768,"DIRECTION":"BI","MASTER_ID":13765,"compounds":"bromochloromethane + H2O <=> bromide + chloride + formaldehyde + 2 H(+)"}
{"X":3062,"KEGG":"R03524","RHEA_ID":17824,"DIRECTION":"BI","MASTER_ID":17821,"metacyc":"L-3-CYANOALANINE-SYNTHASE-RXN","compounds":"hydrogen cyanide + L-cysteine <=> 3-cyano-L-alanine + H(+) + hydrogen sulfide","pmd":6.977}
{"X":3063,"KEGG":"R03528","RHEA_ID":18124,"DIRECTION":"BI","MASTER_ID":18121,"compounds":"an S-substituted L-cysteine + H2O <=> a thiol + NH4(+) + pyruvate"}
{"X":3064,"KEGG":"R03529","RHEA_ID":18780,"DIRECTION":"BI","MASTER_ID":18777,"metacyc":"ALKYLMERCURY-LYASE-RXN","compounds":"an alkylmercury + H(+) <=> an alkane + Hg(2+)"}
{"X":3065,"KEGG":"R03530","RHEA_ID":30942,"DIRECTION":"BI","MASTER_ID":30939,"metacyc":"RXN-14228","compounds":"ATP + dIDP <=> ADP + dITP","pmd":15.011}
{"X":3066,"KEGG":"R03531","RHEA_ID":28345,"DIRECTION":"BI","MASTER_ID":28342,"compounds":"dITP + H2O <=> dIMP + diphosphate + H(+)","pmd":159.933}
{"X":3067,"KEGG":"R03532","RHEA_ID":30278,"DIRECTION":"BI","MASTER_ID":30275,"compounds":"AH2 + H2O2 <=> A + 2 H2O"}
{"X":3068,"KEGG":"R03534","RHEA_ID":25264,"DIRECTION":"BI","MASTER_ID":25261,"compounds":"2-hydroxyglutarate + FAD + H(+) <=> 2-oxoglutarate + FADH2","pmd":2.016}
{"X":3069,"KEGG":"R03536","RHEA_ID":17184,"DIRECTION":"BI","MASTER_ID":17181,"compounds":"a long-chain fatty aldehyde + FMNH2 + O2 <=> a long-chain fatty acid + FMN + 2 H(+) + H2O + hnu"}
{"X":3070,"KEGG":"R03537","RHEA_ID":27889,"DIRECTION":"BI","MASTER_ID":27886,"compounds":"2',3'-cyclic AMP + H2O <=> 3'-AMP + H(+)","pmd":18.011}
{"X":3071,"KEGG":"R03538","RHEA_ID":27881,"DIRECTION":"BI","MASTER_ID":27878,"compounds":"2',3'-cyclic UMP + H2O <=> 3'-UMP + H(+)","pmd":18.011}
{"X":3072,"KEGG":"R03540","RHEA_ID":27388,"DIRECTION":"BI","MASTER_ID":27385,"compounds":"H2O + maleamate <=> maleate + NH4(+)","pmd":0.984}
{"X":3073,"KEGG":"R03541","RHEA_ID":21499,"DIRECTION":"BI","MASTER_ID":21496,"compounds":"dimethylallyl diphosphate + H2O <=> diphosphate + prenol"}
{"X":3074,"KEGG":"R03543","RHEA_ID":13816,"DIRECTION":"BI","MASTER_ID":13813,"compounds":"benzene + H(+) + NADH + O2 <=> cis-1,2-dihydrobenzene-1,2-diol + NAD(+)","pmd":553.072}
{"X":3075,"KEGG":"R03544","RHEA_ID":33202,"DIRECTION":"BI","MASTER_ID":33199,"metacyc":"ENZRXN-161-RXN","compounds":"butan-1-ol + NAD(+) <=> butanal + H(+) + NADH"}
{"X":3076,"KEGG":"R03546","RHEA_ID":17404,"DIRECTION":"BI","MASTER_ID":17401,"metacyc":"RXN-2463","compounds":"2-hydroxy-4-oxobutane-1,2,4-tricarboxylate <=> 4-carboxy-2-hydroxy-cis,cis-muconate + H2O"}
{"X":3077,"KEGG":"R03546","RHEA_ID":18492,"DIRECTION":"BI","MASTER_ID":18489,"compounds":"cyanate + H(+) + hydrogencarbonate <=> carbamate + CO2"}
{"X":3078,"KEGG":"R03547","RHEA_ID":20208,"DIRECTION":"BI","MASTER_ID":20205,"compounds":"methylazoxymethanol + UDP-alpha-D-glucose <=> cycasin + H(+) + UDP","pmd":162.053}
{"X":3079,"KEGG":"R03548","RHEA_ID":14328,"DIRECTION":"BI","MASTER_ID":14325,"compounds":"7,8-dihydroxycoumarin + UDP-alpha-D-glucose <=> daphnin + H(+) + UDP","pmd":162.053}
{"X":3080,"KEGG":"R03550","RHEA_ID":28930,"DIRECTION":"BI","MASTER_ID":28927,"compounds":"3,4,5-trihydroxybenzoate + O2 <=> (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + 2 H(+)","pmd":31.99}
{"X":3081,"KEGG":"R03552","RHEA_ID":21995,"DIRECTION":"BI","MASTER_ID":21992,"compounds":"acetyl-CoA + L-lysyl-[histone] <=> CoA + H(+) + N(6)-acetyl-L-lysyl-[histone]","pmd":42.011}
{"X":3082,"KEGG":"R03554","RHEA_ID":12511,"DIRECTION":"BI","MASTER_ID":12508,"compounds":"loganate + S-adenosyl-L-methionine <=> loganin + S-adenosyl-L-homocysteine","pmd":7.985}
{"X":3083,"KEGG":"R03555","RHEA_ID":20588,"DIRECTION":"BI","MASTER_ID":20585,"compounds":"loganin + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + secologanin","pmd":2.016}
{"X":3084,"KEGG":"R03556","RHEA_ID":11455,"DIRECTION":"BI","MASTER_ID":11452,"compounds":"7-deoxyloganin + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + loganin + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":3085,"KEGG":"R03557","RHEA_ID":19260,"DIRECTION":"BI","MASTER_ID":19257,"compounds":"a secondary alcohol + NADP(+) <=> a ketone + H(+) + NADPH"}
{"X":3086,"KEGG":"R03558","RHEA_ID":11515,"DIRECTION":"BI","MASTER_ID":11512,"compounds":"salicyl alcohol + UDP-alpha-D-glucose <=> H(+) + salicin + UDP","pmd":162.053}
{"X":3087,"KEGG":"R03559","RHEA_ID":16740,"DIRECTION":"BI","MASTER_ID":16737,"compounds":"H(+) + NADH + O2 + toluene <=> (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+)","pmd":539.057}
{"X":3088,"KEGG":"R03563","RHEA_ID":23307,"DIRECTION":"BI","MASTER_ID":23304,"compounds":"atropine + H2O <=> H(+) + tropate + tropine","pmd":123.105}
{"X":3089,"KEGG":"R03565","RHEA_ID":21959,"DIRECTION":"BI","MASTER_ID":21956,"compounds":"UDP-alpha-D-glucose + vitexin <=> H(+) + UDP + vitexin 2''-O-beta-D-glucoside","pmd":28.103}
{"X":3090,"KEGG":"R03565","RHEA_ID":21959,"DIRECTION":"BI","MASTER_ID":21956,"compounds":"UDP-alpha-D-glucose + vitexin <=> H(+) + UDP + vitexin 2''-O-beta-D-glucoside","pmd":28.104}
{"X":3091,"KEGG":"R03567","RHEA_ID":23115,"DIRECTION":"BI","MASTER_ID":23112,"compounds":"6-methylsalicylate + H(+) <=> 3-methylphenol + CO2","pmd":43.99}
{"X":3092,"KEGG":"R03571","RHEA_ID":20432,"DIRECTION":"BI","MASTER_ID":20429,"compounds":"apigenin + S-adenosyl-L-methionine <=> acacetin + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":3093,"KEGG":"R03572","RHEA_ID":12171,"DIRECTION":"BI","MASTER_ID":12168,"compounds":"allyl alcohol + NADP(+) <=> acrolein + H(+) + NADPH"}
{"X":3094,"KEGG":"R03573","RHEA_ID":20680,"DIRECTION":"BI","MASTER_ID":20677,"compounds":"alizarin + UDP-alpha-D-glucose <=> 1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone + H(+) + UDP","pmd":162.053}
{"X":3095,"KEGG":"R03575","RHEA_ID":16352,"DIRECTION":"BI","MASTER_ID":16349,"compounds":"AH2 + chlorate <=> A + chlorite + H2O"}
{"X":3096,"KEGG":"R03576","RHEA_ID":14808,"DIRECTION":"BI","MASTER_ID":14805,"compounds":"ATP + D-allose <=> ADP + D-allose 6-phosphate + H(+)","pmd":79.966}
{"X":3097,"KEGG":"R03577","RHEA_ID":15304,"DIRECTION":"BI","MASTER_ID":15301,"compounds":"D-apiitol + NAD(+) <=> aldehydo-D-apiose + H(+) + NADH","pmd":514.064}
{"X":3098,"KEGG":"R03577","RHEA_ID":15304,"DIRECTION":"BI","MASTER_ID":15301,"compounds":"D-apiitol + NAD(+) <=> aldehydo-D-apiose + H(+) + NADH","pmd":2.016}
{"X":3099,"KEGG":"R03579","RHEA_ID":10487,"DIRECTION":"BI","MASTER_ID":10484,"compounds":"H2O + N-feruloylglycine <=> glycine + trans-ferulate","pmd":57.022}
{"X":3100,"KEGG":"R03581","RHEA_ID":14524,"DIRECTION":"BI","MASTER_ID":14521,"compounds":"geraniol + NADP(+) <=> geranial + H(+) + NADPH","pmd":591.963}
{"X":3101,"KEGG":"R03581","RHEA_ID":14524,"DIRECTION":"BI","MASTER_ID":14521,"compounds":"geraniol + NADP(+) <=> geranial + H(+) + NADPH","pmd":2.016}
{"X":3102,"KEGG":"R03582","RHEA_ID":16320,"DIRECTION":"BI","MASTER_ID":16317,"metacyc":"INDANOL-DEHYDROGENASE-RXN","compounds":"indan-1-ol + NAD(+) <=> H(+) + indan-1-one + NADH","pmd":532.059}
{"X":3103,"KEGG":"R03582","RHEA_ID":16320,"DIRECTION":"BI","MASTER_ID":16317,"metacyc":"INDANOL-DEHYDROGENASE-RXN","compounds":"indan-1-ol + NAD(+) <=> H(+) + indan-1-one + NADH","pmd":2.016}
{"X":3104,"KEGG":"R03583","RHEA_ID":16324,"DIRECTION":"BI","MASTER_ID":16321,"metacyc":"INDANOL-DEHYDROGENASE-RXN","compounds":"indan-1-ol + NADP(+) <=> H(+) + indan-1-one + NADPH","pmd":612.026}
{"X":3105,"KEGG":"R03583","RHEA_ID":16324,"DIRECTION":"BI","MASTER_ID":16321,"metacyc":"INDANOL-DEHYDROGENASE-RXN","compounds":"indan-1-ol + NADP(+) <=> H(+) + indan-1-one + NADPH","pmd":2.016}
{"X":3106,"KEGG":"R03584","RHEA_ID":10331,"DIRECTION":"BI","MASTER_ID":10328,"compounds":"an L-glycol + NAD(+) <=> a 2-hydroxycarbonyl + H(+) + NADH"}
{"X":3107,"KEGG":"R03585","RHEA_ID":10327,"DIRECTION":"BI","MASTER_ID":10324,"compounds":"an L-glycol + NADP(+) <=> a 2-hydroxycarbonyl + H(+) + NADPH"}
{"X":3108,"KEGG":"R03586","RHEA_ID":15792,"DIRECTION":"BI","MASTER_ID":15789,"compounds":"L-xylose + NADP(+) <=> H(+) + L-xylono-1,4-lactone + NADPH","pmd":596.046}
{"X":3109,"KEGG":"R03586","RHEA_ID":15792,"DIRECTION":"BI","MASTER_ID":15789,"compounds":"L-xylose + NADP(+) <=> H(+) + L-xylono-1,4-lactone + NADPH","pmd":2.016}
{"X":3110,"KEGG":"R03587","RHEA_ID":14592,"DIRECTION":"BI","MASTER_ID":14589,"compounds":"luteolin + S-adenosyl-L-methionine <=> 4',5,7-trihydroxy-3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":3111,"KEGG":"R03588","RHEA_ID":19580,"DIRECTION":"BI","MASTER_ID":19577,"compounds":"luteolin + UDP-alpha-D-glucose <=> H(+) + luteolin 7-O-beta-D-glucoside + UDP","pmd":117.954}
{"X":3112,"KEGG":"R03589","RHEA_ID":10571,"DIRECTION":"BI","MASTER_ID":10568,"compounds":"luteolin + UDP-alpha-D-glucuronate <=> H(+) + luteolin 7-O-beta-D-glucuronide + UDP","pmd":117.954}
{"X":3113,"KEGG":"R03589","RHEA_ID":10571,"DIRECTION":"BI","MASTER_ID":10568,"compounds":"luteolin + UDP-alpha-D-glucuronate <=> H(+) + luteolin 7-O-beta-D-glucuronide + UDP","pmd":117.955}
{"X":3114,"KEGG":"R03591","RHEA_ID":14320,"DIRECTION":"BI","MASTER_ID":14317,"metacyc":"MORPHINE-6-DEHYDROGENASE-RXN","compounds":"morphine + NAD(+) <=> H(+) + morphinone + NADH","pmd":380.996}
{"X":3115,"KEGG":"R03591","RHEA_ID":14320,"DIRECTION":"BI","MASTER_ID":14317,"metacyc":"MORPHINE-6-DEHYDROGENASE-RXN","compounds":"morphine + NAD(+) <=> H(+) + morphinone + NADH","pmd":2.016}
{"X":3116,"KEGG":"R03592","RHEA_ID":14324,"DIRECTION":"BI","MASTER_ID":14321,"metacyc":"MORPHINE-6-DEHYDROGENASE-RXN","compounds":"morphine + NADP(+) <=> H(+) + morphinone + NADPH","pmd":460.963}
{"X":3117,"KEGG":"R03592","RHEA_ID":14324,"DIRECTION":"BI","MASTER_ID":14321,"metacyc":"MORPHINE-6-DEHYDROGENASE-RXN","compounds":"morphine + NADP(+) <=> H(+) + morphinone + NADPH","pmd":2.016}
{"X":3118,"KEGG":"R03593","RHEA_ID":22707,"DIRECTION":"BI","MASTER_ID":22704,"compounds":"2 H2O + ricinine <=> 4-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate + NH4(+)","pmd":18.995}
{"X":3119,"KEGG":"R03594","RHEA_ID":20456,"DIRECTION":"BI","MASTER_ID":20453,"compounds":"scopoletin + UDP-alpha-D-glucose <=> H(+) + scopolin + UDP","pmd":162.053}
{"X":3120,"KEGG":"R03595","RHEA_ID":18740,"DIRECTION":"BI","MASTER_ID":18737,"compounds":"ATP + H2O + hydrogenselenide <=> AMP + 2 H(+) + phosphate + selenophosphate","pmd":159.933}
{"X":3121,"KEGG":"R03599","RHEA_ID":11635,"DIRECTION":"BI","MASTER_ID":11632,"ecocyc":"SELENOCYSTEINE-LYASE-RXN","metacyc":"SELENOCYSTEINE-LYASE-RXN","compounds":"AH2 + L-selenocysteine <=> A + H(+) + hydrogenselenide + L-alanine"}
{"X":3122,"KEGG":"R03607","RHEA_ID":20512,"DIRECTION":"BI","MASTER_ID":20509,"metacyc":"VIOMYCIN-KINASE-RXN","compounds":"ATP + viomycin <=> ADP + H(+) + O-phosphoviomycin","pmd":79.966}
{"X":3123,"KEGG":"R03610","RHEA_ID":20576,"DIRECTION":"BI","MASTER_ID":20573,"compounds":"calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> calcitriol + H2O + 2 oxidized [adrenodoxin]","pmd":15.995}
{"X":3124,"KEGG":"R03611","RHEA_ID":32906,"DIRECTION":"BI","MASTER_ID":32903,"compounds":"calciol + O2 + reduced [NADPH--hemoprotein reductase] <=> calcidiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":3125,"KEGG":"R03612","RHEA_ID":23463,"DIRECTION":"BI","MASTER_ID":23460,"compounds":"benzyl cetraxate + H2O <=> benzyl alcohol + cetraxate + H(+)","pmd":90.047}
{"X":3126,"KEGG":"R03613","RHEA_ID":19756,"DIRECTION":"BI","MASTER_ID":19753,"compounds":"ATP + diphthine-[translation elongation factor 2] + NH4(+) <=> AMP + diphosphate + diphthamide-[translation elongation factor 2] + H(+)","pmd":159.933}
{"X":3127,"KEGG":"R03614","RHEA_ID":16292,"DIRECTION":"BI","MASTER_ID":16289,"compounds":"(1R,2S)-ephedrine + NAD(+) <=> (R)-2-methylimino-1-phenylpropan-1-ol + 2 H(+) + NADH","pmd":501.017}
{"X":3128,"KEGG":"R03614","RHEA_ID":16292,"DIRECTION":"BI","MASTER_ID":16289,"compounds":"(1R,2S)-ephedrine + NAD(+) <=> (R)-2-methylimino-1-phenylpropan-1-ol + 2 H(+) + NADH","pmd":2.016}
{"X":3129,"KEGG":"R03615","RHEA_ID":16340,"DIRECTION":"BI","MASTER_ID":16337,"compounds":"a 3'-unsubstituted flavone + O2 + reduced [NADPH--hemoprotein reductase] <=> a 3'-hydroxyflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":3130,"KEGG":"R03617","RHEA_ID":14300,"DIRECTION":"BI","MASTER_ID":14297,"compounds":"a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O <=> an N-acylsphing-4-enine + D-galactose"}
{"X":3131,"KEGG":"R03618","RHEA_ID":21115,"DIRECTION":"BI","MASTER_ID":21112,"compounds":"globoside Gb3Cer (d18:1(4E)) + H2O <=> a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + D-galactose"}
{"X":3132,"KEGG":"R03620","RHEA_ID":20084,"DIRECTION":"BI","MASTER_ID":20081,"compounds":"H2O + N-methylhexanamide <=> hexanoate + methylamine","pmd":13.032}
{"X":3133,"KEGG":"R03621","RHEA_ID":15816,"DIRECTION":"BI","MASTER_ID":15813,"compounds":"1H-imidazole + acetyl-CoA <=> CoA + N-acetylimidazole","pmd":42.011}
{"X":3134,"KEGG":"R03622","RHEA_ID":23607,"DIRECTION":"BI","MASTER_ID":23604,"compounds":"kievitone hydrate <=> H2O + kievitone","pmd":18.011}
{"X":3135,"KEGG":"R03623","RHEA_ID":18524,"DIRECTION":"BI","MASTER_ID":18521,"compounds":"licodione + S-adenosyl-L-methionine <=> 2'-O-methyllicodione + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":3136,"KEGG":"R03624","RHEA_ID":10899,"DIRECTION":"BI","MASTER_ID":10896,"compounds":"2 H2O + limonin <=> 2 H(+) + limonoate","pmd":18.011}
{"X":3137,"KEGG":"R03625","RHEA_ID":20012,"DIRECTION":"BI","MASTER_ID":20009,"compounds":"2-hydroxy-2-methylpropanenitrile + UDP-alpha-D-glucose <=> H(+) + linamarin + UDP","pmd":162.053}
{"X":3138,"KEGG":"R03626","RHEA_ID":22783,"DIRECTION":"BI","MASTER_ID":22780,"compounds":"(9Z,12Z)-octadecadienoate + O2 <=> (13S)-hydroperoxy-(9Z,11E)-octadecadienoate","pmd":31.99}
{"X":3139,"KEGG":"R03627","RHEA_ID":17384,"DIRECTION":"BI","MASTER_ID":17381,"compounds":"(9Z,12Z)-octadecadienoate <=> (9Z,11E)-octadecadienoate","pmd":0}
{"X":3140,"KEGG":"R03630","RHEA_ID":17492,"DIRECTION":"BI","MASTER_ID":17489,"compounds":"H(+) + NADH + O2 + phthalate <=> cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+)","pmd":34.006}
{"X":3141,"KEGG":"R03630","RHEA_ID":17492,"DIRECTION":"BI","MASTER_ID":17489,"compounds":"H(+) + NADH + O2 + phthalate <=> cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+)","pmd":465.093}
{"X":3142,"KEGG":"R03631","RHEA_ID":21383,"DIRECTION":"BI","MASTER_ID":21380,"compounds":"3,7,11,15-tetramethylhexadecanoate + ATP + CoA <=> AMP + diphosphate + phytanoyl-CoA","pmd":420.052}
{"X":3143,"KEGG":"R03631","RHEA_ID":21383,"DIRECTION":"BI","MASTER_ID":21380,"compounds":"3,7,11,15-tetramethylhexadecanoate + ATP + CoA <=> AMP + diphosphate + phytanoyl-CoA","pmd":159.933}
{"X":3144,"KEGG":"R03631","RHEA_ID":21383,"DIRECTION":"BI","MASTER_ID":21380,"compounds":"3,7,11,15-tetramethylhexadecanoate + ATP + CoA <=> AMP + diphosphate + phytanoyl-CoA","pmd":34.76}
{"X":3145,"KEGG":"R03633","RHEA_ID":22283,"DIRECTION":"BI","MASTER_ID":22280,"compounds":"O-demethylpuromycin + S-adenosyl-L-methionine <=> H(+) + puromycin + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":3146,"KEGG":"R03637","RHEA_ID":20392,"DIRECTION":"BI","MASTER_ID":20389,"compounds":"(2R,3R)-dihydroquercetin + H(+) + NADPH + O2 <=> (2R,3R)-2,3-dihydrogossypetin + H2O + NADP(+)","pmd":15.995}
{"X":3147,"KEGG":"R03637","RHEA_ID":20392,"DIRECTION":"BI","MASTER_ID":20389,"compounds":"(2R,3R)-dihydroquercetin + H(+) + NADPH + O2 <=> (2R,3R)-2,3-dihydrogossypetin + H2O + NADP(+)","pmd":345.072}
{"X":3148,"KEGG":"R03638","RHEA_ID":20388,"DIRECTION":"BI","MASTER_ID":20385,"compounds":"(2R,3R)-dihydroquercetin + H(+) + NADH + O2 <=> (2R,3R)-2,3-dihydrogossypetin + H2O + NAD(+)","pmd":425.038}
{"X":3149,"KEGG":"R03638","RHEA_ID":20388,"DIRECTION":"BI","MASTER_ID":20385,"compounds":"(2R,3R)-dihydroquercetin + H(+) + NADH + O2 <=> (2R,3R)-2,3-dihydrogossypetin + H2O + NAD(+)","pmd":15.995}
{"X":3150,"KEGG":"R03639","RHEA_ID":61119,"DIRECTION":"BI","MASTER_ID":61116,"compounds":"(2R,3R)-dihydroquercetin + O2 + reduced [NADPH--hemoprotein reductase] <=> (2R,3R)-dihydromyricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":3151,"KEGG":"R03640","RHEA_ID":61091,"DIRECTION":"BI","MASTER_ID":61088,"compounds":"(S)-eriodictyol + 2-oxoglutarate + O2 <=> (2R,3R)-dihydroquercetin + CO2 + succinate","pmd":15.995}
{"X":3152,"KEGG":"R03640","RHEA_ID":61091,"DIRECTION":"BI","MASTER_ID":61088,"compounds":"(S)-eriodictyol + 2-oxoglutarate + O2 <=> (2R,3R)-dihydroquercetin + CO2 + succinate","pmd":27.995}
{"X":3153,"KEGG":"R03641","RHEA_ID":13724,"DIRECTION":"BI","MASTER_ID":13721,"compounds":"H2O + testololactone <=> H(+) + testolate","pmd":18.011}
{"X":3154,"KEGG":"R03642","RHEA_ID":14044,"DIRECTION":"BI","MASTER_ID":14041,"compounds":"(R)-vicianin + H2O <=> mandelonitrile + vicianose","pmd":115.042}
{"X":3155,"KEGG":"R03642","RHEA_ID":14044,"DIRECTION":"BI","MASTER_ID":14041,"compounds":"(R)-vicianin + H2O <=> mandelonitrile + vicianose","pmd":294.095}
{"X":3156,"KEGG":"R03646","RHEA_ID":20304,"DIRECTION":"BI","MASTER_ID":20301,"compounds":"ATP + L-arginine + tRNA(Arg) <=> AMP + diphosphate + L-arginyl-tRNA(Arg)","pmd":172.951}
{"X":3157,"KEGG":"R03646","RHEA_ID":20304,"DIRECTION":"BI","MASTER_ID":20301,"compounds":"ATP + L-arginine + tRNA(Arg) <=> AMP + diphosphate + L-arginyl-tRNA(Arg)","pmd":159.933}
{"X":3158,"KEGG":"R03647","RHEA_ID":18352,"DIRECTION":"BI","MASTER_ID":18349,"compounds":"ATP + L-aspartate + tRNA(Asx) <=> AMP + diphosphate + L-aspartyl-tRNA(Asx)","pmd":214.026}
{"X":3159,"KEGG":"R03647","RHEA_ID":18352,"DIRECTION":"BI","MASTER_ID":18349,"compounds":"ATP + L-aspartate + tRNA(Asx) <=> AMP + diphosphate + L-aspartyl-tRNA(Asx)","pmd":159.933}
{"X":3160,"KEGG":"R03648","RHEA_ID":11183,"DIRECTION":"BI","MASTER_ID":11180,"compounds":"ATP + L-asparagine + tRNA(Asn) <=> AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)","pmd":215.01}
{"X":3161,"KEGG":"R03648","RHEA_ID":11183,"DIRECTION":"BI","MASTER_ID":11180,"compounds":"ATP + L-asparagine + tRNA(Asn) <=> AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)","pmd":159.933}
{"X":3162,"KEGG":"R03650","RHEA_ID":17776,"DIRECTION":"BI","MASTER_ID":17773,"compounds":"ATP + L-cysteine + tRNA(Cys) <=> AMP + diphosphate + L-cysteinyl-tRNA(Cys)","pmd":226.043}
{"X":3163,"KEGG":"R03650","RHEA_ID":17776,"DIRECTION":"BI","MASTER_ID":17773,"compounds":"ATP + L-cysteine + tRNA(Cys) <=> AMP + diphosphate + L-cysteinyl-tRNA(Cys)","pmd":159.933}
{"X":3164,"KEGG":"R03651","RHEA_ID":18400,"DIRECTION":"BI","MASTER_ID":18397,"compounds":"ATP + L-glutamate + tRNA(Glx) <=> AMP + diphosphate + L-glutamyl-tRNA(Glx)","pmd":159.933}
{"X":3165,"KEGG":"R03651","RHEA_ID":18400,"DIRECTION":"BI","MASTER_ID":18397,"compounds":"ATP + L-glutamate + tRNA(Glx) <=> AMP + diphosphate + L-glutamyl-tRNA(Glx)","pmd":200.01}
{"X":3166,"KEGG":"R03652","RHEA_ID":20124,"DIRECTION":"BI","MASTER_ID":20121,"compounds":"ATP + L-glutamine + tRNA(Gln) <=> AMP + diphosphate + L-glutaminyl-tRNA(Gln)","pmd":159.933}
{"X":3167,"KEGG":"R03652","RHEA_ID":20124,"DIRECTION":"BI","MASTER_ID":20121,"compounds":"ATP + L-glutamine + tRNA(Gln) <=> AMP + diphosphate + L-glutaminyl-tRNA(Gln)","pmd":200.994}
{"X":3168,"KEGG":"R03654","RHEA_ID":16016,"DIRECTION":"BI","MASTER_ID":16013,"compounds":"ATP + glycine + tRNA(Gly) <=> AMP + diphosphate + glycyl-tRNA(Gly)","pmd":159.933}
{"X":3169,"KEGG":"R03655","RHEA_ID":17316,"DIRECTION":"BI","MASTER_ID":17313,"compounds":"ATP + L-histidine + tRNA(His) <=> AMP + diphosphate + H(+) + L-histidyl-tRNA(His)","pmd":191.994}
{"X":3170,"KEGG":"R03655","RHEA_ID":17316,"DIRECTION":"BI","MASTER_ID":17313,"compounds":"ATP + L-histidine + tRNA(His) <=> AMP + diphosphate + H(+) + L-histidyl-tRNA(His)","pmd":159.933}
{"X":3171,"KEGG":"R03656","RHEA_ID":11063,"DIRECTION":"BI","MASTER_ID":11060,"compounds":"ATP + L-isoleucine + tRNA(Ile) <=> AMP + diphosphate + L-isoleucyl-tRNA(Ile)","pmd":159.933}
{"X":3172,"KEGG":"R03656","RHEA_ID":11063,"DIRECTION":"BI","MASTER_ID":11060,"compounds":"ATP + L-isoleucine + tRNA(Ile) <=> AMP + diphosphate + L-isoleucyl-tRNA(Ile)","pmd":215.969}
{"X":3173,"KEGG":"R03657","RHEA_ID":11691,"DIRECTION":"BI","MASTER_ID":11688,"compounds":"ATP + L-leucine + tRNA(Leu) <=> AMP + diphosphate + L-leucyl-tRNA(Leu)","pmd":215.969}
{"X":3174,"KEGG":"R03657","RHEA_ID":11691,"DIRECTION":"BI","MASTER_ID":11688,"compounds":"ATP + L-leucine + tRNA(Leu) <=> AMP + diphosphate + L-leucyl-tRNA(Leu)","pmd":159.933}
{"X":3175,"KEGG":"R03658","RHEA_ID":20795,"DIRECTION":"BI","MASTER_ID":20792,"compounds":"ATP + L-lysine + tRNA(Lys) <=> AMP + diphosphate + L-lysyl-tRNA(Lys)","pmd":159.933}
{"X":3176,"KEGG":"R03658","RHEA_ID":20795,"DIRECTION":"BI","MASTER_ID":20792,"compounds":"ATP + L-lysine + tRNA(Lys) <=> AMP + diphosphate + L-lysyl-tRNA(Lys)","pmd":200.958}
{"X":3177,"KEGG":"R03659","RHEA_ID":13484,"DIRECTION":"BI","MASTER_ID":13481,"compounds":"ATP + L-methionine + tRNA(Met) <=> AMP + diphosphate + L-methionyl-tRNA(Met)","pmd":159.933}
{"X":3178,"KEGG":"R03659","RHEA_ID":13484,"DIRECTION":"BI","MASTER_ID":13481,"compounds":"ATP + L-methionine + tRNA(Met) <=> AMP + diphosphate + L-methionyl-tRNA(Met)","pmd":198.012}
{"X":3179,"KEGG":"R03660","RHEA_ID":19416,"DIRECTION":"BI","MASTER_ID":19413,"compounds":"ATP + L-phenylalanine + tRNA(Phe) <=> AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)","pmd":159.933}
{"X":3180,"KEGG":"R03660","RHEA_ID":19416,"DIRECTION":"BI","MASTER_ID":19413,"compounds":"ATP + L-phenylalanine + tRNA(Phe) <=> AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)","pmd":181.984}
{"X":3181,"KEGG":"R03661","RHEA_ID":14308,"DIRECTION":"BI","MASTER_ID":14305,"compounds":"ATP + L-proline + tRNA(Pro) <=> AMP + diphosphate + L-prolyl-tRNA(Pro)","pmd":159.933}
{"X":3182,"KEGG":"R03661","RHEA_ID":14308,"DIRECTION":"BI","MASTER_ID":14305,"compounds":"ATP + L-proline + tRNA(Pro) <=> AMP + diphosphate + L-prolyl-tRNA(Pro)","pmd":232}
{"X":3183,"KEGG":"R03662","RHEA_ID":12295,"DIRECTION":"BI","MASTER_ID":12292,"compounds":"ATP + L-serine + tRNA(Ser) <=> AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)","pmd":242.021}
{"X":3184,"KEGG":"R03662","RHEA_ID":12295,"DIRECTION":"BI","MASTER_ID":12292,"compounds":"ATP + L-serine + tRNA(Ser) <=> AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)","pmd":159.933}
{"X":3185,"KEGG":"R03663","RHEA_ID":24627,"DIRECTION":"BI","MASTER_ID":24624,"compounds":"ATP + L-threonine + tRNA(Thr) <=> AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)","pmd":228.005}
{"X":3186,"KEGG":"R03663","RHEA_ID":24627,"DIRECTION":"BI","MASTER_ID":24624,"compounds":"ATP + L-threonine + tRNA(Thr) <=> AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)","pmd":159.933}
{"X":3187,"KEGG":"R03664","RHEA_ID":24083,"DIRECTION":"BI","MASTER_ID":24080,"compounds":"ATP + L-tryptophan + tRNA(Trp) <=> AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)","pmd":142.973}
{"X":3188,"KEGG":"R03664","RHEA_ID":24083,"DIRECTION":"BI","MASTER_ID":24080,"compounds":"ATP + L-tryptophan + tRNA(Trp) <=> AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)","pmd":159.933}
{"X":3189,"KEGG":"R03665","RHEA_ID":10707,"DIRECTION":"BI","MASTER_ID":10704,"compounds":"ATP + L-valine + tRNA(Val) <=> AMP + diphosphate + L-valyl-tRNA(Val)","pmd":159.933}
{"X":3190,"KEGG":"R03665","RHEA_ID":10707,"DIRECTION":"BI","MASTER_ID":10704,"compounds":"ATP + L-valine + tRNA(Val) <=> AMP + diphosphate + L-valyl-tRNA(Val)","pmd":229.984}
{"X":3191,"KEGG":"R03667","RHEA_ID":23171,"DIRECTION":"BI","MASTER_ID":23168,"compounds":"coformycin + NADP(+) <=> 8-oxocoformycin + H(+) + NADPH","pmd":2.016}
{"X":3192,"KEGG":"R03667","RHEA_ID":23171,"DIRECTION":"BI","MASTER_ID":23168,"compounds":"coformycin + NADP(+) <=> 8-oxocoformycin + H(+) + NADPH","pmd":461.987}
{"X":3193,"KEGG":"R03668","RHEA_ID":23283,"DIRECTION":"BI","MASTER_ID":23280,"compounds":"acetyl-CoA + cysteamine <=> CoA + S-acetylcysteamine","pmd":42.011}
{"X":3194,"KEGG":"R03671","RHEA_ID":12952,"DIRECTION":"BI","MASTER_ID":12949,"compounds":"D-fuconate <=> 2-dehydro-3-deoxy-D-fuconate + H2O","pmd":18.011}
{"X":3195,"KEGG":"R03673","RHEA_ID":13044,"DIRECTION":"BI","MASTER_ID":13041,"compounds":"L-dopachrome <=> 5,6-dihydroxyindole-2-carboxylate","pmd":0}
{"X":3196,"KEGG":"R03675","RHEA_ID":22067,"DIRECTION":"BI","MASTER_ID":22064,"metacyc":"5-ALPHA-HYDROXYSTEROID-DEHYDRATASE-RXN","compounds":"5alpha-ergosta-7,22-diene-3beta,5-diol <=> ergosterol + H2O","pmd":18.011}
{"X":3197,"KEGG":"R03677","RHEA_ID":33830,"DIRECTION":"BI","MASTER_ID":33827,"compounds":"ergosterol <=> vitamin D2","pmd":0}
{"X":3198,"KEGG":"R03678","RHEA_ID":16380,"DIRECTION":"BI","MASTER_ID":16377,"compounds":"(3Z)-phytochromobilin + 2 oxidized [2Fe-2S]-[ferredoxin] <=> biliverdin IXalpha + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]","pmd":2.016}
{"X":3199,"KEGG":"R03680","RHEA_ID":20028,"DIRECTION":"BI","MASTER_ID":20025,"compounds":"gibberellin A3 + UDP-alpha-D-glucose <=> gibberellin A3 O-beta-D-glucoside + H(+) + UDP","pmd":57.86}
{"X":3200,"KEGG":"R03680","RHEA_ID":20028,"DIRECTION":"BI","MASTER_ID":20025,"compounds":"gibberellin A3 + UDP-alpha-D-glucose <=> gibberellin A3 O-beta-D-glucoside + H(+) + UDP","pmd":57.861}
{"X":3201,"KEGG":"R03681","RHEA_ID":23363,"DIRECTION":"BI","MASTER_ID":23360,"compounds":"L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose <=> alpha-D-glucosyl-L-tyrosyl-[glycogenin] + H(+) + UDP","pmd":162.053}
{"X":3202,"KEGG":"R03685","RHEA_ID":15044,"DIRECTION":"BI","MASTER_ID":15041,"compounds":"bis-D-fructose 2',1:2,1'-dianhydride + H2O <=> inulobiose","pmd":18.011}
{"X":3203,"KEGG":"R03686","RHEA_ID":19532,"DIRECTION":"BI","MASTER_ID":19529,"compounds":"isovitexin + UDP-alpha-D-glucose <=> H(+) + isovitexin 2''-O-beta-D-glucoside + UDP","pmd":28.104}
{"X":3204,"KEGG":"R03686","RHEA_ID":19532,"DIRECTION":"BI","MASTER_ID":19529,"compounds":"isovitexin + UDP-alpha-D-glucose <=> H(+) + isovitexin 2''-O-beta-D-glucoside + UDP","pmd":28.103}
{"X":3205,"KEGG":"R03687","RHEA_ID":16700,"DIRECTION":"BI","MASTER_ID":16697,"compounds":"A + H2O + quinaldate <=> AH2 + kynurenate","pmd":15.995}
{"X":3206,"KEGG":"R03688","RHEA_ID":22775,"DIRECTION":"BI","MASTER_ID":22772,"metacyc":"L-FUCONATE-HYDRATASE-RXN","compounds":"L-fuconate <=> 2-dehydro-3-deoxy-L-fuconate + H2O","pmd":18.011}
{"X":3207,"KEGG":"R03689","RHEA_ID":33922,"DIRECTION":"BI","MASTER_ID":33919,"compounds":"H(+) + lanosterol + NADPH <=> 24,25-dihydrolanosterol + NADP(+)","pmd":2.016}
{"X":3208,"KEGG":"R03689","RHEA_ID":33922,"DIRECTION":"BI","MASTER_ID":33919,"compounds":"H(+) + lanosterol + NADPH <=> 24,25-dihydrolanosterol + NADP(+)","pmd":316.689}
{"X":3209,"KEGG":"R03692","RHEA_ID":10363,"DIRECTION":"BI","MASTER_ID":10360,"compounds":"3,4-dihydrocoumarin + H2O <=> 3-(2-hydroxyphenyl)propanoate + H(+)","pmd":18.011}
{"X":3210,"KEGG":"R03693","RHEA_ID":13532,"DIRECTION":"BI","MASTER_ID":13529,"metacyc":"S-2-METHYLMALATE-DEHYDRATASE-RXN","compounds":"(3S)-citramalate <=> H2O + mesaconate","pmd":18.011}
{"X":3211,"KEGG":"R03696","RHEA_ID":12832,"DIRECTION":"BI","MASTER_ID":12829,"metacyc":"METHYLASPARTATE-AMMONIA-LYASE-RXN","compounds":"(2S,3S)-3-methyl-L-aspartate <=> mesaconate + NH4(+)","pmd":17.027}
{"X":3212,"KEGG":"R03700","RHEA_ID":14140,"DIRECTION":"BI","MASTER_ID":14137,"compounds":"3'-phosphoadenylyl sulfate + beta-D-galactosyl-(1<->1)-sphing-4-enine <=> 6-O-sulfo-beta-D-galactosyl-(1<->1)-sphing-4-enine + adenosine 3',5'-bisphosphate + H(+)","pmd":34.306}
{"X":3213,"KEGG":"R03702","RHEA_ID":22263,"DIRECTION":"BI","MASTER_ID":22260,"compounds":"H2O + triacetate lactone <=> H(+) + triacetate","pmd":18.011}
{"X":3214,"KEGG":"R03703","RHEA_ID":14560,"DIRECTION":"BI","MASTER_ID":14557,"compounds":"H2O + raucaffricine <=> D-glucose + vomilenine","pmd":162.053}
{"X":3215,"KEGG":"R03704","RHEA_ID":16876,"DIRECTION":"BI","MASTER_ID":16873,"compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + FADH2 + uridine(54) in tRNA <=> (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + FAD + H(+)","pmd":12}
{"X":3216,"KEGG":"R03704","RHEA_ID":16876,"DIRECTION":"BI","MASTER_ID":16873,"compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + FADH2 + uridine(54) in tRNA <=> (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + FAD + H(+)","pmd":2.016}
{"X":3217,"KEGG":"R03707","RHEA_ID":12187,"DIRECTION":"BI","MASTER_ID":12184,"metacyc":"SS-BUTANEDIOL-DEHYDROGENASE-RXN","compounds":"(S,S)-butane-2,3-diol + NAD(+) <=> (S)-acetoin + H(+) + NADH"}
{"X":3218,"KEGG":"R03708","RHEA_ID":12748,"DIRECTION":"BI","MASTER_ID":12745,"compounds":"a 1,4-lactone + H2O <=> a 4-hydroxyacid + H(+)"}
{"X":3219,"KEGG":"R03709","RHEA_ID":21447,"DIRECTION":"BI","MASTER_ID":21444,"compounds":"3-(2-hydroxyphenyl)propanoate + NAD(+) <=> H(+) + NADH + trans-2-coumarate","pmd":2.016}
{"X":3220,"KEGG":"R03709","RHEA_ID":21447,"DIRECTION":"BI","MASTER_ID":21444,"compounds":"3-(2-hydroxyphenyl)propanoate + NAD(+) <=> H(+) + NADH + trans-2-coumarate","pmd":500.07}
{"X":3221,"KEGG":"R03710","RHEA_ID":10239,"DIRECTION":"BI","MASTER_ID":10236,"compounds":"trans-2-coumarate + UDP-alpha-D-glucose <=> H(+) + trans-beta-D-glucosyl-2-hydroxycinnamate + UDP","pmd":162.053}
{"X":3222,"KEGG":"R03712","RHEA_ID":10799,"DIRECTION":"BI","MASTER_ID":10796,"compounds":"albendazole + H(+) + NADPH + O2 <=> albendazole S-oxide + H2O + NADP(+)","pmd":15.995}
{"X":3223,"KEGG":"R03712","RHEA_ID":10799,"DIRECTION":"BI","MASTER_ID":10796,"compounds":"albendazole + H(+) + NADPH + O2 <=> albendazole S-oxide + H2O + NADP(+)","pmd":464.008}
{"X":3224,"KEGG":"R03716","RHEA_ID":14404,"DIRECTION":"BI","MASTER_ID":14401,"metacyc":"CHLORDECONE-REDUCTASE-RXN","compounds":"chlordecone alcohol + NADP(+) <=> chlordecone + H(+) + NADPH","pmd":2.016}
{"X":3225,"KEGG":"R03716","RHEA_ID":14404,"DIRECTION":"BI","MASTER_ID":14401,"metacyc":"CHLORDECONE-REDUCTASE-RXN","compounds":"chlordecone alcohol + NADP(+) <=> chlordecone + H(+) + NADPH","pmd":258.4}
{"X":3226,"KEGG":"R03718","RHEA_ID":14004,"DIRECTION":"BI","MASTER_ID":14001,"compounds":"choloyl-CoA + glycine <=> CoA + glycocholate + H(+)"}
{"X":3227,"KEGG":"R03719","RHEA_ID":16868,"DIRECTION":"BI","MASTER_ID":16865,"compounds":"choloyl-CoA + propanoyl-CoA <=> 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + CoA","pmd":56.026}
{"X":3228,"KEGG":"R03721","RHEA_ID":15376,"DIRECTION":"BI","MASTER_ID":15373,"compounds":"columbamine + S-adenosyl-L-methionine <=> H(+) + palmatine + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":3229,"KEGG":"R03723","RHEA_ID":10887,"DIRECTION":"BI","MASTER_ID":10884,"compounds":"(24R,24(1)R)-fucosterol epoxide <=> acetaldehyde + cholesta-5,24-dien-3beta-ol","pmd":44.026}
{"X":3230,"KEGG":"R03726","RHEA_ID":19584,"DIRECTION":"BI","MASTER_ID":19581,"compounds":"N(6)-dimethylallyladenine + S-adenosyl-L-methionine <=> discadenine + H(+) + S-methyl-5'-thioadenosine","pmd":93.973}
{"X":3231,"KEGG":"R03726","RHEA_ID":19584,"DIRECTION":"BI","MASTER_ID":19581,"compounds":"N(6)-dimethylallyladenine + S-adenosyl-L-methionine <=> discadenine + H(+) + S-methyl-5'-thioadenosine","pmd":93.972}
{"X":3232,"KEGG":"R03727","RHEA_ID":13000,"DIRECTION":"BI","MASTER_ID":12997,"compounds":"(E)-feruloyl-CoA + galactarate <=> 2-O-[(E)-feruloyl]-D-galactarate + CoA","pmd":176.047}
{"X":3233,"KEGG":"R03728","RHEA_ID":14664,"DIRECTION":"BI","MASTER_ID":14661,"compounds":"octadecanal <=> CO + heptadecane","pmd":504.809}
{"X":3234,"KEGG":"R03728","RHEA_ID":14664,"DIRECTION":"BI","MASTER_ID":14661,"compounds":"octadecanal <=> CO + heptadecane","pmd":27.995}
{"X":3235,"KEGG":"R03728","RHEA_ID":21443,"DIRECTION":"BI","MASTER_ID":21440,"compounds":"a long-chain fatty aldehyde + H(+) + 2 NADPH + O2 <=> a long-chain alkane + formate + H2O + 2 NADP(+)","pmd":504.809}
{"X":3236,"KEGG":"R03728","RHEA_ID":21443,"DIRECTION":"BI","MASTER_ID":21440,"compounds":"a long-chain fatty aldehyde + H(+) + 2 NADPH + O2 <=> a long-chain alkane + formate + H2O + 2 NADP(+)","pmd":27.995}
{"X":3237,"KEGG":"R03731","RHEA_ID":24099,"DIRECTION":"BI","MASTER_ID":24096,"compounds":"isoorientin + S-adenosyl-L-methionine <=> H(+) + isoscoparin + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":3238,"KEGG":"R03732","RHEA_ID":21595,"DIRECTION":"BI","MASTER_ID":21592,"metacyc":"1.5.1.28-RXN","compounds":"(2S)-2-[(R)-1-carboxyethylamino]pentanoate + H2O + NAD(+) <=> H(+) + L-2-aminopentanoate + NADH + pyruvate","pmd":72.021}
{"X":3239,"KEGG":"R03732","RHEA_ID":21595,"DIRECTION":"BI","MASTER_ID":21592,"metacyc":"1.5.1.28-RXN","compounds":"(2S)-2-[(R)-1-carboxyethylamino]pentanoate + H2O + NAD(+) <=> H(+) + L-2-aminopentanoate + NADH + pyruvate","pmd":547.038}
{"X":3240,"KEGG":"R03733","RHEA_ID":23379,"DIRECTION":"BI","MASTER_ID":23376,"compounds":"L-threonate + NAD(+) <=> 3-dehydro-D-erythronate + H(+) + NADH","pmd":2.016}
{"X":3241,"KEGG":"R03733","RHEA_ID":23379,"DIRECTION":"BI","MASTER_ID":23376,"compounds":"L-threonate + NAD(+) <=> 3-dehydro-D-erythronate + H(+) + NADH","pmd":530.095}
{"X":3242,"KEGG":"R03734","RHEA_ID":19748,"DIRECTION":"BI","MASTER_ID":19745,"compounds":"3,3',5-triiodo-L-thyronine + A + H(+) + iodide <=> AH2 + L-thyroxine","pmd":125.897}
{"X":3243,"KEGG":"R03735","RHEA_ID":16608,"DIRECTION":"BI","MASTER_ID":16605,"compounds":"dodecanoyl-CoA + H2O + oxaloacetate <=> (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA + H(+)","pmd":182.167}
{"X":3244,"KEGG":"R03735","RHEA_ID":16608,"DIRECTION":"BI","MASTER_ID":16605,"compounds":"dodecanoyl-CoA + H2O + oxaloacetate <=> (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA + H(+)","pmd":200.178}
{"X":3245,"KEGG":"R03736","RHEA_ID":11295,"DIRECTION":"BI","MASTER_ID":11292,"compounds":"2 H(+) + O2 + rifamycin B <=> H2O2 + rifamycin O","pmd":2.016}
{"X":3246,"KEGG":"R03737","RHEA_ID":12800,"DIRECTION":"BI","MASTER_ID":12797,"compounds":"(6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2 <=> CO2 + H(+) + H2O + scopolamine + succinate","pmd":27.995}
{"X":3247,"KEGG":"R03737","RHEA_ID":12800,"DIRECTION":"BI","MASTER_ID":12797,"compounds":"(6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2 <=> CO2 + H(+) + H2O + scopolamine + succinate","pmd":2.016}
{"X":3248,"KEGG":"R03738","RHEA_ID":15016,"DIRECTION":"BI","MASTER_ID":15013,"compounds":"3alpha(S)-strictosidine + H2O <=> secologanin + tryptamine","pmd":142.089}
{"X":3249,"KEGG":"R03739","RHEA_ID":13888,"DIRECTION":"BI","MASTER_ID":13885,"compounds":"H2O + stipitatonate <=> CO2 + stipitatate","pmd":25.979}
{"X":3250,"KEGG":"R03742","RHEA_ID":23879,"DIRECTION":"BI","MASTER_ID":23876,"compounds":"protoaphin aglucone <=> H2O + xanthoaphin","pmd":18.011}
{"X":3251,"KEGG":"R03743","RHEA_ID":20404,"DIRECTION":"BI","MASTER_ID":20401,"compounds":"a beta-lactam + H2O <=> a substituted beta-amino acid"}
{"X":3252,"KEGG":"R03744","RHEA_ID":53907,"DIRECTION":"BI","MASTER_ID":53904,"metacyc":"TAU-PROTEIN-KINASE-RXN","compounds":"[tau protein]-L-threonine + ATP <=> [tau protein]-O-phospho-L-threonine + ADP + H(+)","pmd":79.966}
{"X":3253,"KEGG":"R03744","RHEA_ID":12804,"DIRECTION":"BI","MASTER_ID":12801,"metacyc":"TAU-PROTEIN-KINASE-RXN","compounds":"[tau protein]-L-serine + ATP <=> [tau protein]-O-phospho-L-serine + ADP + H(+)","pmd":79.966}
{"X":3254,"KEGG":"R03745","RHEA_ID":18332,"DIRECTION":"BI","MASTER_ID":18329,"compounds":"(1S,3R,5S)-sabinol + NAD(+) <=> (1S,5S)-sabinone + H(+) + NADH","pmd":2.016}
{"X":3255,"KEGG":"R03745","RHEA_ID":18332,"DIRECTION":"BI","MASTER_ID":18329,"compounds":"(1S,3R,5S)-sabinol + NAD(+) <=> (1S,5S)-sabinone + H(+) + NADH","pmd":514.012}
{"X":3256,"KEGG":"R03746","RHEA_ID":14316,"DIRECTION":"BI","MASTER_ID":14313,"compounds":"2-iodophenol + S-adenosyl-L-methionine <=> 1-iodo-2-methoxybenzene + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":3257,"KEGG":"R03747","RHEA_ID":13388,"DIRECTION":"BI","MASTER_ID":13385,"compounds":"3-oxododecanoate + H(+) <=> 2-undecanone + CO2","pmd":43.99}
{"X":3258,"KEGG":"R03748","RHEA_ID":21783,"DIRECTION":"BI","MASTER_ID":21780,"compounds":"A + cyclohexanone <=> AH2 + cyclohex-2-enone","pmd":2.016}
{"X":3259,"KEGG":"R03748","RHEA_ID":13332,"DIRECTION":"BI","MASTER_ID":13329,"compounds":"A + a 3-oxosteroid <=> a 3-oxo-Delta(1)-steroid + AH2","pmd":2.016}
{"X":3260,"KEGG":"R03749","RHEA_ID":20508,"DIRECTION":"BI","MASTER_ID":20505,"compounds":"an alpha-(gamma-L-glutamyl)-L-amino acid <=> 5-oxo-L-proline + an L-alpha-amino acid"}
{"X":3261,"KEGG":"R03753","RHEA_ID":20236,"DIRECTION":"BI","MASTER_ID":20233,"metacyc":"1.1.1.201-RXN","compounds":"a 7beta-hydroxysteroid + NADP(+) <=> a 7-oxosteroid + H(+) + NADPH","pmd":2.016}
{"X":3262,"KEGG":"R03753","RHEA_ID":20236,"DIRECTION":"BI","MASTER_ID":20233,"metacyc":"1.1.1.201-RXN","compounds":"a 7beta-hydroxysteroid + NADP(+) <=> a 7-oxosteroid + H(+) + NADPH","pmd":469.854}
{"X":3263,"KEGG":"R03758","RHEA_ID":25656,"DIRECTION":"BI","MASTER_ID":25653,"compounds":"(2S)-2-amino-3-oxobutanoate + H(+) <=> aminoacetone + CO2"}
{"X":3264,"KEGG":"R03759","RHEA_ID":16520,"DIRECTION":"BI","MASTER_ID":16517,"compounds":"(R)-1-aminopropan-2-ol + NAD(+) <=> aminoacetone + H(+) + NADH"}
{"X":3265,"KEGG":"R03760","RHEA_ID":20500,"DIRECTION":"BI","MASTER_ID":20497,"metacyc":"ARALKYLAMINE-N-ACETYLTRANSFERASE-RXN","compounds":"2-arylethylamine + acetyl-CoA <=> CoA + H(+) + N-acetyl-2-arylethylamine","pmd":42.011}
{"X":3266,"KEGG":"R03761","RHEA_ID":14884,"DIRECTION":"BI","MASTER_ID":14881,"compounds":"3-mercapto-2-mercaptomethylpropanoate + NAD(+) <=> asparagusate + H(+) + NADH","pmd":2.016}
{"X":3267,"KEGG":"R03761","RHEA_ID":14884,"DIRECTION":"BI","MASTER_ID":14881,"compounds":"3-mercapto-2-mercaptomethylpropanoate + NAD(+) <=> asparagusate + H(+) + NADH","pmd":513.128}
{"X":3268,"KEGG":"R03763","RHEA_ID":20656,"DIRECTION":"BI","MASTER_ID":20653,"compounds":"23,24-dihydrocucurbitacin B + NAD(+) <=> cucurbitacin B + H(+) + NADH","pmd":105.798}
{"X":3269,"KEGG":"R03763","RHEA_ID":20656,"DIRECTION":"BI","MASTER_ID":20653,"compounds":"23,24-dihydrocucurbitacin B + NAD(+) <=> cucurbitacin B + H(+) + NADH","pmd":2.016}
{"X":3270,"KEGG":"R03764","RHEA_ID":20652,"DIRECTION":"BI","MASTER_ID":20649,"compounds":"23,24-dihydrocucurbitacin B + NADP(+) <=> cucurbitacin B + H(+) + NADPH","pmd":185.764}
{"X":3271,"KEGG":"R03764","RHEA_ID":20652,"DIRECTION":"BI","MASTER_ID":20649,"compounds":"23,24-dihydrocucurbitacin B + NADP(+) <=> cucurbitacin B + H(+) + NADPH","pmd":2.016}
{"X":3272,"KEGG":"R03766","RHEA_ID":22799,"DIRECTION":"BI","MASTER_ID":22796,"compounds":"ATP + D-hamamelose <=> ADP + D-hamamelose 2'-phosphate + H(+)","pmd":79.966}
{"X":3273,"KEGG":"R03767","RHEA_ID":14444,"DIRECTION":"BI","MASTER_ID":14441,"metacyc":"GENTAMICIN-3-N-ACETYLTRANSFERASE-RXN","compounds":"acetyl-CoA + gentamicin C <=> CoA + H(+) + N(3)-acetylgentamycin C","pmd":42.011}
{"X":3274,"KEGG":"R03770","RHEA_ID":23391,"DIRECTION":"BI","MASTER_ID":23388,"metacyc":"HYGROMYCIN-B-KINASE-RXN","compounds":"ATP + hygromycin B <=> 7''-O-phosphohygromycin B + ADP + H(+)","pmd":79.966}
{"X":3275,"KEGG":"R03771","RHEA_ID":10671,"DIRECTION":"BI","MASTER_ID":10668,"compounds":"1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) <=> 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys)"}
{"X":3276,"KEGG":"R03772","RHEA_ID":10291,"DIRECTION":"BI","MASTER_ID":10288,"compounds":"H2O + L-rhamnono-1,4-lactone <=> H(+) + L-rhamnonate","pmd":18.011}
{"X":3277,"KEGG":"R03774","RHEA_ID":23083,"DIRECTION":"BI","MASTER_ID":23080,"ecocyc":"L-RHAMNONATE-DEHYDRATASE-RXN","metacyc":"L-RHAMNONATE-DEHYDRATASE-RXN","compounds":"L-rhamnonate <=> 2-dehydro-3-deoxy-L-rhamnonate + H2O","pmd":18.011}
{"X":3278,"KEGG":"R03775","RHEA_ID":22803,"DIRECTION":"BI","MASTER_ID":22800,"compounds":"cycloeucalenol <=> obtusifoliol","pmd":0}
{"X":3279,"KEGG":"R03777","RHEA_ID":30946,"DIRECTION":"BI","MASTER_ID":30943,"compounds":"FAD + H(+) + octanoyl-CoA <=> (2E)-octenoyl-CoA + FADH2","pmd":2.016}
{"X":3280,"KEGG":"R03778","RHEA_ID":31090,"DIRECTION":"BI","MASTER_ID":31087,"compounds":"acetyl-CoA + octanoyl-CoA <=> 3-oxodecanoyl-CoA + CoA","pmd":42.011}
{"X":3281,"KEGG":"R03778","RHEA_ID":31090,"DIRECTION":"BI","MASTER_ID":31087,"compounds":"acetyl-CoA + octanoyl-CoA <=> 3-oxodecanoyl-CoA + CoA","pmd":42.01}
{"X":3282,"KEGG":"R03779","RHEA_ID":17180,"DIRECTION":"BI","MASTER_ID":17177,"metacyc":"CARNITINE-O-OCTANOYLTRANSFERASE-RXN","compounds":"(R)-carnitine + octanoyl-CoA <=> CoA + O-octanoyl-(R)-carnitine","pmd":126.105}
{"X":3283,"KEGG":"R03780","RHEA_ID":18336,"DIRECTION":"BI","MASTER_ID":18333,"compounds":"ATP + oleandomycin <=> ADP + H(+) + oleandomycin 2'-O-phosphate","pmd":79.966}
{"X":3284,"KEGG":"R03781","RHEA_ID":11911,"DIRECTION":"BI","MASTER_ID":11908,"metacyc":"BETA-DIKETONE-HYDROLASE-RXN","compounds":"H2O + nonane-4,6-dione <=> butanoate + H(+) + pentan-2-one"}
{"X":3285,"KEGG":"R03782","RHEA_ID":21519,"DIRECTION":"BI","MASTER_ID":21516,"compounds":"isopiperitenone <=> piperitenone","pmd":0}
{"X":3286,"KEGG":"R03785","RHEA_ID":22519,"DIRECTION":"BI","MASTER_ID":22516,"metacyc":"TAUROCYAMINE-KINASE-RXN","compounds":"ATP + taurocyamine <=> ADP + H(+) + N-phosphotaurocyamine","pmd":79.966}
{"X":3287,"KEGG":"R03787","RHEA_ID":13420,"DIRECTION":"BI","MASTER_ID":13417,"compounds":"5,12-dihydroxanthommatin + NAD(+) <=> H(+) + NADH + xanthommatin","pmd":241.047}
{"X":3288,"KEGG":"R03787","RHEA_ID":13420,"DIRECTION":"BI","MASTER_ID":13417,"compounds":"5,12-dihydroxanthommatin + NAD(+) <=> H(+) + NADH + xanthommatin","pmd":2.016}
{"X":3289,"KEGG":"R03788","RHEA_ID":22747,"DIRECTION":"BI","MASTER_ID":22744,"compounds":"a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":3290,"KEGG":"R03789","RHEA_ID":16636,"DIRECTION":"BI","MASTER_ID":16633,"compounds":"guanosine(34) in tRNA + queuine <=> guanine + queuosine(34) in tRNA","pmd":126.068}
{"X":3291,"KEGG":"R03790","RHEA_ID":43115,"DIRECTION":"BI","MASTER_ID":43112,"metacyc":"RXN-15840","compounds":"(R)-mandelate + NAD(+) <=> H(+) + NADH + phenylglyoxylate","pmd":514.085}
{"X":3292,"KEGG":"R03790","RHEA_ID":43115,"DIRECTION":"BI","MASTER_ID":43112,"metacyc":"RXN-15840","compounds":"(R)-mandelate + NAD(+) <=> H(+) + NADH + phenylglyoxylate","pmd":2.016}
{"X":3293,"KEGG":"R03791","RHEA_ID":13948,"DIRECTION":"BI","MASTER_ID":13945,"compounds":"(S)-mandelate <=> (R)-mandelate","pmd":0}
{"X":3294,"KEGG":"R03793","RHEA_ID":15752,"DIRECTION":"BI","MASTER_ID":15749,"compounds":"(S)-mandelate + A <=> AH2 + phenylglyoxylate","pmd":2.016}
{"X":3295,"KEGG":"R03794","RHEA_ID":21719,"DIRECTION":"BI","MASTER_ID":21716,"compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + (S)-mandelate + O2 <=> (6R)-L-erythro-6,7-dihydrobiopterin + (S)-4-hydroxymandelate + H2O","pmd":2.038}
{"X":3296,"KEGG":"R03794","RHEA_ID":21719,"DIRECTION":"BI","MASTER_ID":21716,"compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + (S)-mandelate + O2 <=> (6R)-L-erythro-6,7-dihydrobiopterin + (S)-4-hydroxymandelate + H2O","pmd":18.011}
{"X":3297,"KEGG":"R03796","RHEA_ID":11627,"DIRECTION":"BI","MASTER_ID":11624,"compounds":"2-(hydroxyimino)propanoate + acetone <=> acetone oxime + pyruvate"}
{"X":3298,"KEGG":"R03797","RHEA_ID":20096,"DIRECTION":"BI","MASTER_ID":20093,"compounds":"an anthocyanidin + H(+) + UDP-alpha-D-glucose <=> an anthocyanidin 3-O-beta-D-glucoside + UDP","pmd":162.053}
{"X":3299,"KEGG":"R03799","RHEA_ID":13812,"DIRECTION":"BI","MASTER_ID":13809,"metacyc":"ASPULVINONE-DIMETHYLALLYLTRANSFERASE-RXN","compounds":"aspulvinone E + 2 dimethylallyl diphosphate <=> aspulvinone H + 2 diphosphate","pmd":136.125}
{"X":3300,"KEGG":"R03799","RHEA_ID":13812,"DIRECTION":"BI","MASTER_ID":13809,"metacyc":"ASPULVINONE-DIMETHYLALLYLTRANSFERASE-RXN","compounds":"aspulvinone E + 2 dimethylallyl diphosphate <=> aspulvinone H + 2 diphosphate","pmd":186.188}
{"X":3301,"KEGG":"R03800","RHEA_ID":10151,"DIRECTION":"BI","MASTER_ID":10148,"metacyc":"BLASTICIDIN-S-DEAMINASE-RXN","compounds":"blasticidin S + H(+) + H2O <=> deaminohydroxyblasticidin S + NH4(+)","pmd":0.984}
{"X":3302,"KEGG":"R03803","RHEA_ID":15000,"DIRECTION":"BI","MASTER_ID":14997,"compounds":"deoxylimonoate + H2O <=> deoxylimononate D-ring-lactone + H(+)","pmd":18.011}
{"X":3303,"KEGG":"R03804","RHEA_ID":11719,"DIRECTION":"BI","MASTER_ID":11716,"metacyc":"OMEGA-AMIDASE-RXN","compounds":"a monoamide of a dicarboxylate + H2O <=> a dicarboxylate + NH4(+)"}
{"X":3304,"KEGG":"R03805","RHEA_ID":11223,"DIRECTION":"BI","MASTER_ID":11220,"compounds":"a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":3305,"KEGG":"R03810","RHEA_ID":21811,"DIRECTION":"BI","MASTER_ID":21808,"compounds":"2,5-dioxopiperazine + H2O <=> glycylglycine","pmd":18.011}
{"X":3306,"KEGG":"R03812","RHEA_ID":12632,"DIRECTION":"BI","MASTER_ID":12629,"compounds":"2-oxoglutarate + L-hyoscyamine + O2 <=> (6S)-6-hydroxyhyoscyamine + CO2 + succinate","pmd":15.995}
{"X":3307,"KEGG":"R03812","RHEA_ID":12632,"DIRECTION":"BI","MASTER_ID":12629,"compounds":"2-oxoglutarate + L-hyoscyamine + O2 <=> (6S)-6-hydroxyhyoscyamine + CO2 + succinate","pmd":27.995}
{"X":3308,"KEGG":"R03814","RHEA_ID":22199,"DIRECTION":"BI","MASTER_ID":22196,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + AH2 + O2 <=> (6Z,9Z,12Z)-octadecatrienoyl-CoA + A + 2 H2O"}
{"X":3309,"KEGG":"R03814","RHEA_ID":47143,"DIRECTION":"BI","MASTER_ID":47140,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":3310,"KEGG":"R03815","RHEA_ID":15048,"DIRECTION":"BI","MASTER_ID":15045,"compounds":"(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) <=> (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH"}
{"X":3311,"KEGG":"R03817","RHEA_ID":22151,"DIRECTION":"BI","MASTER_ID":22148,"compounds":"a plastoquinol + 2 H(+)(in) + 2 oxidized [plastocyanin] <=> a plastoquinone + 4 H(+)(out) + 2 reduced [plastocyanin]"}
{"X":3312,"KEGG":"R03818","RHEA_ID":13528,"DIRECTION":"BI","MASTER_ID":13525,"compounds":"(1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin] <=> (1R,4R,5R)-5-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin]","pmd":15.995}
{"X":3313,"KEGG":"R03820","RHEA_ID":12920,"DIRECTION":"BI","MASTER_ID":12917,"compounds":"3alpha(S)-strictosidine + H2O <=> D-glucose + strictosidine aglycone","pmd":162.053}
{"X":3314,"KEGG":"R03821","RHEA_ID":16760,"DIRECTION":"BI","MASTER_ID":16757,"metacyc":"1.8.1.12-RXN","compounds":"NADP(+) + trypanothione <=> H(+) + NADPH + trypanothione disulfide","pmd":2.016}
{"X":3315,"KEGG":"R03821","RHEA_ID":16760,"DIRECTION":"BI","MASTER_ID":16757,"metacyc":"1.8.1.12-RXN","compounds":"NADP(+) + trypanothione <=> H(+) + NADPH + trypanothione disulfide","pmd":22.795}
{"X":3316,"KEGG":"R03822","RHEA_ID":21535,"DIRECTION":"BI","MASTER_ID":21532,"metacyc":"6.3.1.9-RXN","compounds":"ATP + glutathione + glutathionylspermidine <=> ADP + H(+) + phosphate + trypanothione","pmd":79.966}
{"X":3317,"KEGG":"R03822","RHEA_ID":21535,"DIRECTION":"BI","MASTER_ID":21532,"metacyc":"6.3.1.9-RXN","compounds":"ATP + glutathione + glutathionylspermidine <=> ADP + H(+) + phosphate + trypanothione","pmd":7.202}
{"X":3318,"KEGG":"R03822","RHEA_ID":21535,"DIRECTION":"BI","MASTER_ID":21532,"metacyc":"6.3.1.9-RXN","compounds":"ATP + glutathione + glutathionylspermidine <=> ADP + H(+) + phosphate + trypanothione","pmd":119.946}
{"X":3319,"KEGG":"R03824","RHEA_ID":32242,"DIRECTION":"BI","MASTER_ID":32239,"compounds":"gamma-carotene <=> all-trans-beta-carotene","pmd":0}
{"X":3320,"KEGG":"R03827","RHEA_ID":11231,"DIRECTION":"BI","MASTER_ID":11228,"metacyc":"FLAVANONE-4-REDUCTASE-RXN","compounds":"(2S)-flavan-4-ol + NADP(+) <=> (2S)-flavanone + H(+) + NADPH","pmd":520}
{"X":3321,"KEGG":"R03827","RHEA_ID":11231,"DIRECTION":"BI","MASTER_ID":11228,"metacyc":"FLAVANONE-4-REDUCTASE-RXN","compounds":"(2S)-flavan-4-ol + NADP(+) <=> (2S)-flavanone + H(+) + NADPH","pmd":2.016}
{"X":3322,"KEGG":"R03828","RHEA_ID":54595,"DIRECTION":"BI","MASTER_ID":54592,"compounds":"a 5'-end diphospho-(purine-ribonucleoside) in mRNA + GTP + H(+) <=> a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + diphosphate"}
{"X":3323,"KEGG":"R03830","RHEA_ID":11195,"DIRECTION":"BI","MASTER_ID":11192,"compounds":"an (S)-2-haloacid + H2O <=> a (2R)-2-hydroxycarboxylate + a halide anion + H(+)"}
{"X":3324,"KEGG":"R03831","RHEA_ID":19888,"DIRECTION":"BI","MASTER_ID":19885,"compounds":"(S)-reticuline + O2 <=> (S)-scoulerine + H(+) + H2O2","pmd":2.016}
{"X":3325,"KEGG":"R03832","RHEA_ID":17792,"DIRECTION":"BI","MASTER_ID":17789,"compounds":"(S)-3'-hydroxy-N-methylcoclaurine + S-adenosyl-L-methionine <=> (S)-reticuline + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":3326,"KEGG":"R03834","RHEA_ID":20488,"DIRECTION":"BI","MASTER_ID":20485,"compounds":"(S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-cheilanthifoline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]","pmd":2.016}
{"X":3327,"KEGG":"R03835","RHEA_ID":23811,"DIRECTION":"BI","MASTER_ID":23808,"compounds":"(S)-scoulerine + S-adenosyl-L-methionine <=> (S)-tetrahydrocolumbamine + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":3328,"KEGG":"R03840","RHEA_ID":15672,"DIRECTION":"BI","MASTER_ID":15669,"metacyc":"POLYNUCLEOTIDE-5-HYDROXYL-KINASE-RXN","compounds":"5'-dephospho-(DNA) + ATP <=> ADP + H(+) + phospho-5'-(DNA)","pmd":79.966}
{"X":3329,"KEGG":"R03841","RHEA_ID":13080,"DIRECTION":"BI","MASTER_ID":13077,"compounds":"an acyl phosphate + D-hexose <=> a carboxylate + D-hexose phosphate + H(+)"}
{"X":3330,"KEGG":"R03842","RHEA_ID":23687,"DIRECTION":"BI","MASTER_ID":23684,"compounds":"(S)-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] <=> allocryptopine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":14.987}
{"X":3331,"KEGG":"R03845","RHEA_ID":11135,"DIRECTION":"BI","MASTER_ID":11132,"compounds":"chlorophyllide a + NADP(+) <=> H(+) + NADPH + protochlorophyllide a","pmd":2.016}
{"X":3332,"KEGG":"R03845","RHEA_ID":11135,"DIRECTION":"BI","MASTER_ID":11132,"compounds":"chlorophyllide a + NADP(+) <=> H(+) + NADPH + protochlorophyllide a","pmd":131.861}
{"X":3333,"KEGG":"R03854","RHEA_ID":16076,"DIRECTION":"BI","MASTER_ID":16073,"metacyc":"4.1.1.64-RXN","compounds":"2,2-dialkylglycine + H(+) + pyruvate <=> CO2 + dialkyl ketone + L-alanine"}
{"X":3334,"KEGG":"R03857","RHEA_ID":31042,"DIRECTION":"BI","MASTER_ID":31039,"compounds":"dodecanoyl-CoA + FAD + H(+) <=> (2E)-dodecenoyl-CoA + FADH2","pmd":2.016}
{"X":3335,"KEGG":"R03858","RHEA_ID":31094,"DIRECTION":"BI","MASTER_ID":31091,"compounds":"acetyl-CoA + dodecanoyl-CoA <=> 3-oxotetradecanoyl-CoA + CoA","pmd":42.011}
{"X":3336,"KEGG":"R03859","RHEA_ID":10367,"DIRECTION":"BI","MASTER_ID":10364,"compounds":"2-oxoglutarate + dodecanoyl-CoA + H2O <=> (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H(+)","pmd":182.167}
{"X":3337,"KEGG":"R03859","RHEA_ID":10367,"DIRECTION":"BI","MASTER_ID":10364,"compounds":"2-oxoglutarate + dodecanoyl-CoA + H2O <=> (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H(+)","pmd":200.178}
{"X":3338,"KEGG":"R03860","RHEA_ID":11379,"DIRECTION":"BI","MASTER_ID":11376,"metacyc":"GEISSOSCHIZINE-DEHYDROGENASE-RXN","compounds":"(19S)-geissoschizine + NADP(+) <=> 4,21-dehydrogeissoschizine + NADPH","pmd":392.912}
{"X":3339,"KEGG":"R03861","RHEA_ID":14264,"DIRECTION":"BI","MASTER_ID":14261,"compounds":"D-glucono-1,5-lactone + sinapoyl-CoA <=> 6-O-sinapoyl-D-glucono-1,5-lactone + CoA","pmd":589.067}
{"X":3340,"KEGG":"R03861","RHEA_ID":14264,"DIRECTION":"BI","MASTER_ID":14261,"compounds":"D-glucono-1,5-lactone + sinapoyl-CoA <=> 6-O-sinapoyl-D-glucono-1,5-lactone + CoA","pmd":206.058}
{"X":3341,"KEGG":"R03862","RHEA_ID":10211,"DIRECTION":"BI","MASTER_ID":10208,"metacyc":"ARGINYLTRANSFERASE-RXN","compounds":"an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) <=> H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg)"}
{"X":3342,"KEGG":"R03866","RHEA_ID":22179,"DIRECTION":"BI","MASTER_ID":22176,"compounds":"leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":3343,"KEGG":"R03868","RHEA_ID":17396,"DIRECTION":"BI","MASTER_ID":17393,"compounds":"3-maleylpyruvate <=> 3-fumarylpyruvate","pmd":0}
{"X":3344,"KEGG":"R03869","RHEA_ID":31046,"DIRECTION":"BI","MASTER_ID":31043,"compounds":"(S)-methylmalonate semialdehyde + H2O + NAD(+) <=> 2 H(+) + methylmalonate + NADH","pmd":15.995}
{"X":3345,"KEGG":"R03869","RHEA_ID":31046,"DIRECTION":"BI","MASTER_ID":31043,"compounds":"(S)-methylmalonate semialdehyde + H2O + NAD(+) <=> 2 H(+) + methylmalonate + NADH","pmd":546.09}
{"X":3346,"KEGG":"R03873","RHEA_ID":16944,"DIRECTION":"BI","MASTER_ID":16941,"compounds":"N-acetylindoxyl + O2 <=> H2O + N-acetylisatin","pmd":13.979}
{"X":3347,"KEGG":"R03874","RHEA_ID":20927,"DIRECTION":"BI","MASTER_ID":20924,"metacyc":"PEPTIDYLAMIDOGLYCOLATE-LYASE-RXN","compounds":"a [peptide]-C-terminal (2S)-2-hydroxyglycine <=> a [peptide]-C-terminal amide + glyoxylate"}
{"X":3348,"KEGG":"R03875","RHEA_ID":51739,"DIRECTION":"BI","MASTER_ID":51736,"compounds":"L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":3349,"KEGG":"R03877","RHEA_ID":13964,"DIRECTION":"BI","MASTER_ID":13961,"compounds":"ATP + H2O + Mg(2+) + protoporphyrin IX <=> ADP + 3 H(+) + Mg-protoporphyrin IX + phosphate","pmd":21.969}
{"X":3350,"KEGG":"R03877","RHEA_ID":13964,"DIRECTION":"BI","MASTER_ID":13961,"compounds":"ATP + H2O + Mg(2+) + protoporphyrin IX <=> ADP + 3 H(+) + Mg-protoporphyrin IX + phosphate","pmd":77.232}
{"X":3351,"KEGG":"R03880","RHEA_ID":22531,"DIRECTION":"BI","MASTER_ID":22528,"metacyc":"2.4.1.159-RXN","compounds":"a flavonol 3-O-beta-D-glucoside + UDP-beta-L-rhamnose <=> a flavonol 3-O-[alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + H(+) + UDP","pmd":3.886}
{"X":3352,"KEGG":"R03881","RHEA_ID":23495,"DIRECTION":"BI","MASTER_ID":23492,"compounds":"UDP-alpha-D-glucosamine <=> UDP-alpha-D-galactosamine","pmd":0}
{"X":3353,"KEGG":"R03882","RHEA_ID":23615,"DIRECTION":"BI","MASTER_ID":23612,"compounds":"1,2-dihydro-alpha-santonin + NAD(+) <=> alpha-santonin + H(+) + NADH","pmd":2.016}
{"X":3354,"KEGG":"R03882","RHEA_ID":23615,"DIRECTION":"BI","MASTER_ID":23612,"compounds":"1,2-dihydro-alpha-santonin + NAD(+) <=> alpha-santonin + H(+) + NADH","pmd":417.991}
{"X":3355,"KEGG":"R03883","RHEA_ID":23619,"DIRECTION":"BI","MASTER_ID":23616,"compounds":"1,2-dihydro-alpha-santonin + NADP(+) <=> alpha-santonin + H(+) + NADPH","pmd":497.958}
{"X":3356,"KEGG":"R03883","RHEA_ID":23619,"DIRECTION":"BI","MASTER_ID":23616,"compounds":"1,2-dihydro-alpha-santonin + NADP(+) <=> alpha-santonin + H(+) + NADPH","pmd":2.016}
{"X":3357,"KEGG":"R03884","RHEA_ID":23211,"DIRECTION":"BI","MASTER_ID":23208,"metacyc":"GLUTACONATE-COA-TRANSFERASE-RXN","compounds":"acetyl-CoA + trans-glutaconate <=> (2E)-glutaconyl-CoA + acetate","pmd":70.005}
{"X":3358,"KEGG":"R03884","RHEA_ID":23211,"DIRECTION":"BI","MASTER_ID":23208,"metacyc":"GLUTACONATE-COA-TRANSFERASE-RXN","compounds":"acetyl-CoA + trans-glutaconate <=> (2E)-glutaconyl-CoA + acetate","pmd":749.105}
{"X":3359,"KEGG":"R03885","RHEA_ID":12868,"DIRECTION":"BI","MASTER_ID":12865,"compounds":"1-methyladenosine + H2O <=> 1-methyladenine + D-ribose","pmd":131.06}
{"X":3360,"KEGG":"R03886","RHEA_ID":20883,"DIRECTION":"BI","MASTER_ID":20880,"compounds":"10-hydroxydecanoate + NAD(+) <=> 10-oxodecanoate + H(+) + NADH","pmd":2.016}
{"X":3361,"KEGG":"R03886","RHEA_ID":20883,"DIRECTION":"BI","MASTER_ID":20880,"compounds":"10-hydroxydecanoate + NAD(+) <=> 10-oxodecanoate + H(+) + NADH","pmd":477.991}
{"X":3362,"KEGG":"R03887","RHEA_ID":20999,"DIRECTION":"BI","MASTER_ID":20996,"compounds":"(2Z,4E)-2-aminomuconate + H2O <=> (3E)-2-oxohex-3-enedioate + NH4(+)","pmd":0.984}
{"X":3363,"KEGG":"R03889","RHEA_ID":14472,"DIRECTION":"BI","MASTER_ID":14469,"compounds":"2-aminomuconate 6-semialdehyde + H2O + NAD(+) <=> (2Z,4E)-2-aminomuconate + 2 H(+) + NADH","pmd":507.079}
{"X":3364,"KEGG":"R03889","RHEA_ID":14472,"DIRECTION":"BI","MASTER_ID":14469,"compounds":"2-aminomuconate 6-semialdehyde + H2O + NAD(+) <=> (2Z,4E)-2-aminomuconate + 2 H(+) + NADH","pmd":15.995}
{"X":3365,"KEGG":"R03892","RHEA_ID":42435,"DIRECTION":"BI","MASTER_ID":42432,"compounds":"3-hydroxy-cis,cis-muconate <=> maleylacetate","pmd":0}
{"X":3366,"KEGG":"R03893","RHEA_ID":12375,"DIRECTION":"BI","MASTER_ID":12372,"compounds":"2-(5-oxo-2,5-dihydrofuran-2-ylidene)acetate + H2O <=> 4-oxohex-2-enedioate + H(+)","pmd":18.011}
{"X":3367,"KEGG":"R03894","RHEA_ID":21111,"DIRECTION":"BI","MASTER_ID":21108,"compounds":"(S)-3-methyl-2-oxopentanoate + H(+) <=> 2-methylbutanal + CO2"}
{"X":3368,"KEGG":"R03896","RHEA_ID":22335,"DIRECTION":"BI","MASTER_ID":22332,"compounds":"(3R)-citramalate <=> 2-methylmaleate + H2O","pmd":18.011}
{"X":3369,"KEGG":"R03898","RHEA_ID":42427,"DIRECTION":"BI","MASTER_ID":42424,"compounds":"2-methylmaleate + H2O <=> (2R,3S)-3-methylmalate","pmd":18.011}
{"X":3370,"KEGG":"R03899","RHEA_ID":25803,"DIRECTION":"BI","MASTER_ID":25800,"compounds":"H2O + N(1)-acetylspermine + O2 <=> 3-acetamidopropanal + H2O2 + spermidine","pmd":99.068}
{"X":3371,"KEGG":"R03899","RHEA_ID":16136,"DIRECTION":"BI","MASTER_ID":16133,"metacyc":"POLYAMINE-OXIDASE-RXN","compounds":"H2O + N(1)-acetylspermine + O2 <=> 3-aminopropanal + H2O2 + N(1)-acetylspermidine","pmd":99.068}
{"X":3372,"KEGG":"R03900","RHEA_ID":23895,"DIRECTION":"BI","MASTER_ID":23892,"compounds":"3-nitropropanoate + NADP(+) <=> 3-nitroacrylate + H(+) + NADPH","pmd":627.077}
{"X":3373,"KEGG":"R03900","RHEA_ID":23895,"DIRECTION":"BI","MASTER_ID":23892,"compounds":"3-nitropropanoate + NADP(+) <=> 3-nitroacrylate + H(+) + NADPH","pmd":2.016}
{"X":3374,"KEGG":"R03901","RHEA_ID":20144,"DIRECTION":"BI","MASTER_ID":20141,"metacyc":"ALLIIN-LYASE-RXN","compounds":"an S-alkyl-L-cysteine S-oxide <=> 2-aminoprop-2-enoate + an S-alkyl sulfenate"}
{"X":3375,"KEGG":"R03905","RHEA_ID":17524,"DIRECTION":"BI","MASTER_ID":17521,"compounds":"ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) <=> ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate","pmd":0.984}
{"X":3376,"KEGG":"R03905","RHEA_ID":17524,"DIRECTION":"BI","MASTER_ID":17521,"compounds":"ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) <=> ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate","pmd":79.966}
{"X":3377,"KEGG":"R03906","RHEA_ID":17372,"DIRECTION":"BI","MASTER_ID":17369,"compounds":"glycyrrhizin + H2O <=> 2-(beta-D-glucuronosyl)-D-glucuronate + glycyrrhetinate","pmd":352.064}
{"X":3378,"KEGG":"R03907","RHEA_ID":12680,"DIRECTION":"BI","MASTER_ID":12677,"compounds":"AH2 + Latia luciferin + 2 O2 <=> A + CO2 + formate + H(+) + H2O + hnu + oxidized Latia luciferin","pmd":42.011}
{"X":3379,"KEGG":"R03908","RHEA_ID":13796,"DIRECTION":"BI","MASTER_ID":13793,"compounds":"2-methyleneglutarate <=> 2-methylene-3-methylsuccinate","pmd":0}
{"X":3380,"KEGG":"R03909","RHEA_ID":12023,"DIRECTION":"BI","MASTER_ID":12020,"metacyc":"AMIDASE-RXN","compounds":"a monocarboxylic acid amide + H2O <=> a monocarboxylate + NH4(+)"}
{"X":3381,"KEGG":"R03910","RHEA_ID":11119,"DIRECTION":"BI","MASTER_ID":11116,"compounds":"acetyl-CoA + an alkane-alpha,omega-diamine <=> an N-acetylalkane-alpha,omega-diamine + CoA + H(+)","pmd":42.011}
{"X":3382,"KEGG":"R03912","RHEA_ID":21455,"DIRECTION":"BI","MASTER_ID":21452,"compounds":"a [peptide]-C-terminal glycine + 2 L-ascorbate + O2 <=> a [peptide]-C-terminal (2S)-2-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical"}
{"X":3383,"KEGG":"R03913","RHEA_ID":18752,"DIRECTION":"BI","MASTER_ID":18749,"metacyc":"1.6.4.4-RXN","compounds":"[protein]-dithiol + NAD(+) <=> [protein]-disulfide + H(+) + NADH"}
{"X":3384,"KEGG":"R03914","RHEA_ID":18756,"DIRECTION":"BI","MASTER_ID":18753,"metacyc":"1.6.4.4-RXN","compounds":"[protein]-dithiol + NADP(+) <=> [protein]-disulfide + H(+) + NADPH"}
{"X":3385,"KEGG":"R03915","RHEA_ID":21067,"DIRECTION":"BI","MASTER_ID":21064,"metacyc":"PRODISULFREDUCT-RXN","compounds":"[protein]-disulfide + 2 glutathione <=> [protein]-dithiol + glutathione disulfide","pmd":305.068}
{"X":3386,"KEGG":"R03916","RHEA_ID":59471,"DIRECTION":"BI","MASTER_ID":59468,"compounds":"an S-substituted glutathione + H2O <=> an S-substitued L-cysteinylglycine + L-glutamate"}
{"X":3387,"KEGG":"R03918","RHEA_ID":45707,"DIRECTION":"BI","MASTER_ID":45704,"compounds":"(E)-sinapoyl alcohol + NADP(+) <=> (E)-sinapoaldehyde + H(+) + NADPH","pmd":536.01}
{"X":3388,"KEGG":"R03918","RHEA_ID":45707,"DIRECTION":"BI","MASTER_ID":45704,"compounds":"(E)-sinapoyl alcohol + NADP(+) <=> (E)-sinapoaldehyde + H(+) + NADPH","pmd":2.016}
{"X":3389,"KEGG":"R03922","RHEA_ID":19620,"DIRECTION":"BI","MASTER_ID":19617,"compounds":"a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":3390,"KEGG":"R03923","RHEA_ID":24179,"DIRECTION":"BI","MASTER_ID":24176,"compounds":"[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]","pmd":15.977}
{"X":3391,"KEGG":"R03925","RHEA_ID":10807,"DIRECTION":"BI","MASTER_ID":10804,"metacyc":"ALLANTOIN-RACEMASE-RXN","compounds":"(S)-allantoin <=> (R)-allantoin","pmd":0}
{"X":3392,"KEGG":"R03928","RHEA_ID":15292,"DIRECTION":"BI","MASTER_ID":15289,"compounds":"[(1->4)-beta-D-xylan](n) + UDP-alpha-D-xylose <=> [(1->4)-beta-D-xylan](n+1) + H(+) + UDP","pmd":132.042}
{"X":3393,"KEGG":"R03929","RHEA_ID":27885,"DIRECTION":"BI","MASTER_ID":27882,"compounds":"2',3'-cyclic CMP + H2O <=> 3'-CMP + H(+)","pmd":18.011}
{"X":3394,"KEGG":"R03930","RHEA_ID":20260,"DIRECTION":"BI","MASTER_ID":20257,"compounds":"3-methyloxindole + NADP(+) <=> 3-methyleneoxindole + H(+) + NADPH","pmd":2.016}
{"X":3395,"KEGG":"R03930","RHEA_ID":20260,"DIRECTION":"BI","MASTER_ID":20257,"compounds":"3-methyloxindole + NADP(+) <=> 3-methyleneoxindole + H(+) + NADPH","pmd":599.031}
{"X":3396,"KEGG":"R03932","RHEA_ID":23223,"DIRECTION":"BI","MASTER_ID":23220,"compounds":"4-chlorobenzoate + ATP + CoA <=> 4-chlorobenzoyl-CoA + AMP + diphosphate","pmd":159.933}
{"X":3397,"KEGG":"R03932","RHEA_ID":23223,"DIRECTION":"BI","MASTER_ID":23220,"compounds":"4-chlorobenzoate + ATP + CoA <=> 4-chlorobenzoyl-CoA + AMP + diphosphate","pmd":137.987}
{"X":3398,"KEGG":"R03932","RHEA_ID":23223,"DIRECTION":"BI","MASTER_ID":23220,"compounds":"4-chlorobenzoate + ATP + CoA <=> 4-chlorobenzoyl-CoA + AMP + diphosphate","pmd":191.065}
{"X":3399,"KEGG":"R03933","RHEA_ID":34346,"DIRECTION":"BI","MASTER_ID":34343,"compounds":"(20R,22R)-20,22-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 4-methylpentanal + 2 H2O + 2 oxidized [adrenodoxin] + pregnenolone","pmd":102.104}
{"X":3400,"KEGG":"R03934","RHEA_ID":15204,"DIRECTION":"BI","MASTER_ID":15201,"compounds":"6-hydroxymellein + S-adenosyl-L-methionine <=> 6-methoxymellein + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":3401,"KEGG":"R03935","RHEA_ID":59619,"DIRECTION":"BI","MASTER_ID":59616,"compounds":"beta-alanyl-L-arginine + H2O <=> beta-alanine + L-arginine","pmd":71.037}
{"X":3402,"KEGG":"R03937","RHEA_ID":42451,"DIRECTION":"BI","MASTER_ID":42448,"compounds":"(R)-2-hydroxyglutaryl-CoA <=> (2E)-glutaconyl-CoA + H2O","pmd":18.01}
{"X":3403,"KEGG":"R03938","RHEA_ID":10027,"DIRECTION":"BI","MASTER_ID":10024,"compounds":"L-lysyl-[histone] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":3404,"KEGG":"R03939","RHEA_ID":24011,"DIRECTION":"BI","MASTER_ID":24008,"compounds":"ATP + hypotaurocyamine <=> ADP + H(+) + N(omega)-phosphohypotaurocyamine","pmd":79.966}
{"X":3405,"KEGG":"R03940","RHEA_ID":24383,"DIRECTION":"BI","MASTER_ID":24380,"compounds":"(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) <=> (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)","pmd":27.995}
{"X":3406,"KEGG":"R03942","RHEA_ID":12652,"DIRECTION":"BI","MASTER_ID":12649,"metacyc":"L-RHAMNOSE-1-DEHYDROGENASE-RXN","compounds":"L-rhamnofuranose + NAD(+) <=> H(+) + L-rhamnono-1,4-lactone + NADH","pmd":502.064}
{"X":3407,"KEGG":"R03942","RHEA_ID":12652,"DIRECTION":"BI","MASTER_ID":12649,"metacyc":"L-RHAMNOSE-1-DEHYDROGENASE-RXN","compounds":"L-rhamnofuranose + NAD(+) <=> H(+) + L-rhamnono-1,4-lactone + NADH","pmd":2.016}
{"X":3408,"KEGG":"R03944","RHEA_ID":23091,"DIRECTION":"BI","MASTER_ID":23088,"compounds":"ATP + O-alkylglycerone <=> 1-O-alkylglycerone 3-phosphate + ADP + H(+)","pmd":79.966}
{"X":3409,"KEGG":"R03945","RHEA_ID":10667,"DIRECTION":"BI","MASTER_ID":10664,"compounds":"NAD(+) + perillyl alcohol <=> H(+) + NADH + perillyl aldehyde","pmd":2.016}
{"X":3410,"KEGG":"R03945","RHEA_ID":10667,"DIRECTION":"BI","MASTER_ID":10664,"compounds":"NAD(+) + perillyl alcohol <=> H(+) + NADH + perillyl aldehyde","pmd":514.012}
{"X":3411,"KEGG":"R03947","RHEA_ID":15616,"DIRECTION":"BI","MASTER_ID":15613,"ecocyc":"DIMETHUROPORDEHYDROG-RXN","metacyc":"DIMETHUROPORDEHYDROG-RXN","compounds":"NAD(+) + precorrin-2 <=> 2 H(+) + NADH + sirohydrochlorin","pmd":2.016}
{"X":3412,"KEGG":"R03947","RHEA_ID":15616,"DIRECTION":"BI","MASTER_ID":15613,"ecocyc":"DIMETHUROPORDEHYDROG-RXN","metacyc":"DIMETHUROPORDEHYDROG-RXN","compounds":"NAD(+) + precorrin-2 <=> 2 H(+) + NADH + sirohydrochlorin","pmd":198.174}
{"X":3413,"KEGG":"R03948","RHEA_ID":16844,"DIRECTION":"BI","MASTER_ID":16841,"metacyc":"2.1.1.130-RXN","compounds":"precorrin-2 + S-adenosyl-L-methionine <=> H(+) + precorrin-3A + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":3414,"KEGG":"R03952","RHEA_ID":19136,"DIRECTION":"BI","MASTER_ID":19133,"metacyc":"THYROID-HORMONE-AMINOTRANSFERASE-RXN","compounds":"2-oxoglutarate + 3,3',5-triiodo-L-thyronine <=> 3,5,3'-triiodothyropyruvate + L-glutamate","pmd":1.032}
{"X":3415,"KEGG":"R03956","RHEA_ID":17920,"DIRECTION":"BI","MASTER_ID":17917,"compounds":"[Glu(-Cys)](n)-Gly + glutathione + H(+) <=> [Glu(-Cys)](n+1)-Gly + glycine"}
{"X":3416,"KEGG":"R03959","RHEA_ID":10643,"DIRECTION":"BI","MASTER_ID":10640,"compounds":"muconolactone <=> cis,cis-muconate + H(+)","pmd":0}
{"X":3417,"KEGG":"R03960","RHEA_ID":31054,"DIRECTION":"BI","MASTER_ID":31051,"compounds":"(3R)-beta-leucine + H2O + NAD(+) <=> 3-oxo-4-methylpentanoate + H(+) + NADH + NH4(+)"}
{"X":3418,"KEGG":"R03962","RHEA_ID":17148,"DIRECTION":"BI","MASTER_ID":17145,"compounds":"2'-hydroxy-2,3-dihydrodaidzein + NADP(+) <=> 2'-hydroxydaidzein + 2 H(+) + NADPH","pmd":474.031}
{"X":3419,"KEGG":"R03962","RHEA_ID":17148,"DIRECTION":"BI","MASTER_ID":17145,"compounds":"2'-hydroxy-2,3-dihydrodaidzein + NADP(+) <=> 2'-hydroxydaidzein + 2 H(+) + NADPH","pmd":2.016}
{"X":3420,"KEGG":"R03963","RHEA_ID":19104,"DIRECTION":"BI","MASTER_ID":19101,"compounds":"2-butyne-1,4-diol + NAD(+) <=> 4-hydroxy-2-butynal + H(+) + NADH"}
{"X":3421,"KEGG":"R03964","RHEA_ID":11999,"DIRECTION":"BI","MASTER_ID":11996,"compounds":"2-hydroxybiphenyl + H(+) + NADH + O2 <=> biphenyl-2,3-diol + H2O + NAD(+)","pmd":15.995}
{"X":3422,"KEGG":"R03964","RHEA_ID":11999,"DIRECTION":"BI","MASTER_ID":11996,"compounds":"2-hydroxybiphenyl + H(+) + NADH + O2 <=> biphenyl-2,3-diol + H2O + NAD(+)","pmd":479.057}
{"X":3423,"KEGG":"R03965","RHEA_ID":10955,"DIRECTION":"BI","MASTER_ID":10952,"compounds":"hydroxymalonate + sinapoyl-CoA <=> CoA + sinapoyltartronate","pmd":206.058}
{"X":3424,"KEGG":"R03966","RHEA_ID":32214,"DIRECTION":"BI","MASTER_ID":32211,"metacyc":"RXN-8529","compounds":"(Z)-5-oxohex-2-enedioate <=> (2E,4Z)-2-hydroxyhexa-2,4-dienedioate","pmd":0}
{"X":3425,"KEGG":"R03968","RHEA_ID":16296,"DIRECTION":"BI","MASTER_ID":16293,"ecocyc":"3-ISOPROPYLMALISOM-RXN","metacyc":"3-ISOPROPYLMALISOM-RXN","compounds":"2-isopropylmaleate + H2O <=> (2S)-2-isopropylmalate","pmd":18.011}
{"X":3426,"KEGG":"R03969","RHEA_ID":15864,"DIRECTION":"BI","MASTER_ID":15861,"compounds":"3-ADP-2-phosphoglycerate + H2O <=> 3-ADP-glycerate + phosphate","pmd":79.966}
{"X":3427,"KEGG":"R03974","RHEA_ID":31514,"DIRECTION":"BI","MASTER_ID":31511,"compounds":"chenodeoxycholoyl-CoA + H2O <=> chenodeoxycholate + CoA + H(+)"}
{"X":3428,"KEGG":"R03977","RHEA_ID":16312,"DIRECTION":"BI","MASTER_ID":16309,"compounds":"H2O + taurochenodeoxycholate <=> chenodeoxycholate + taurine","pmd":107.004}
{"X":3429,"KEGG":"R03978","RHEA_ID":11575,"DIRECTION":"BI","MASTER_ID":11572,"metacyc":"RXN-8659","compounds":"FAD + H(+) + H2O + lithocholate <=> chenodeoxycholate + FADH2","pmd":2.016}
{"X":3430,"KEGG":"R03978","RHEA_ID":11575,"DIRECTION":"BI","MASTER_ID":11572,"metacyc":"RXN-8659","compounds":"FAD + H(+) + H2O + lithocholate <=> chenodeoxycholate + FADH2","pmd":15.995}
{"X":3431,"KEGG":"R03980","RHEA_ID":31058,"DIRECTION":"BI","MASTER_ID":31055,"compounds":"estrone 3-sulfate + H2O <=> estrone + H(+) + sulfate","pmd":79.957}
{"X":3432,"KEGG":"R03982","RHEA_ID":18688,"DIRECTION":"BI","MASTER_ID":18685,"compounds":"H(+) + NADPH + O2 + pentachlorophenol <=> 2,3,5,6-tetrachloro-1,4-benzoquinone + chloride + H2O + NADP(+)","pmd":501.226}
{"X":3433,"KEGG":"R03982","RHEA_ID":18688,"DIRECTION":"BI","MASTER_ID":18685,"compounds":"H(+) + NADPH + O2 + pentachlorophenol <=> 2,3,5,6-tetrachloro-1,4-benzoquinone + chloride + H2O + NADP(+)","pmd":19.982}
{"X":3434,"KEGG":"R03983","RHEA_ID":43771,"DIRECTION":"BI","MASTER_ID":43768,"compounds":"an alkylamine + L-glutaminyl-[protein] <=> N(5)-alkyl-L-glutaminyl-[protein] + NH4(+)"}
{"X":3435,"KEGG":"R03984","RHEA_ID":10723,"DIRECTION":"BI","MASTER_ID":10720,"compounds":"2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 glutathione","pmd":15.995}
{"X":3436,"KEGG":"R03984","RHEA_ID":10723,"DIRECTION":"BI","MASTER_ID":10720,"compounds":"2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 glutathione","pmd":305.068}
{"X":3437,"KEGG":"R03987","RHEA_ID":14016,"DIRECTION":"BI","MASTER_ID":14013,"metacyc":"BILE-SALT-SULFOTRANSFERASE-RXN","compounds":"3'-phosphoadenylyl sulfate + taurolithocholate <=> adenosine 3',5'-bisphosphate + H(+) + taurolithocholate sulfate","pmd":56.272}
{"X":3438,"KEGG":"R03990","RHEA_ID":28361,"DIRECTION":"BI","MASTER_ID":28358,"compounds":"FAD + H(+) + tetradecanoyl-CoA <=> (2E)-tetradecenoyl-CoA + FADH2","pmd":2.016}
{"X":3439,"KEGG":"R03991","RHEA_ID":18164,"DIRECTION":"BI","MASTER_ID":18161,"compounds":"acetyl-CoA + tetradecanoyl-CoA <=> 3-oxohexadecanoyl-CoA + CoA","pmd":210.198}
{"X":3440,"KEGG":"R03991","RHEA_ID":18164,"DIRECTION":"BI","MASTER_ID":18161,"compounds":"acetyl-CoA + tetradecanoyl-CoA <=> 3-oxohexadecanoyl-CoA + CoA","pmd":42.011}
{"X":3441,"KEGG":"R03992","RHEA_ID":15524,"DIRECTION":"BI","MASTER_ID":15521,"metacyc":"2.3.1.97-RXN","compounds":"N-terminal glycyl-[protein] + tetradecanoyl-CoA <=> CoA + H(+) + N-tetradecanoylglycyl-[protein]","pmd":210.198}
{"X":3442,"KEGG":"R03994","RHEA_ID":14564,"DIRECTION":"BI","MASTER_ID":14561,"compounds":"(E,E)-piperoyl-CoA + piperidine <=> CoA + H(+) + N-[(E,E)-piperoyl]piperidine","pmd":200.047}
{"X":3443,"KEGG":"R03996","RHEA_ID":19752,"DIRECTION":"BI","MASTER_ID":19749,"metacyc":"ALPHA-13-GLUCAN-SYNTHASE-RXN","compounds":"[(1->3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose <=> [(1->3)-alpha-D-glucosyl](n+1) + H(+) + UDP","pmd":162.053}
{"X":3444,"KEGG":"R03997","RHEA_ID":20923,"DIRECTION":"BI","MASTER_ID":20920,"compounds":"2,4-dichlorophenol + H(+) + NADPH + O2 <=> 3,5-dichlorocatechol + H2O + NADP(+)","pmd":567.132}
{"X":3445,"KEGG":"R03997","RHEA_ID":20923,"DIRECTION":"BI","MASTER_ID":20920,"compounds":"2,4-dichlorophenol + H(+) + NADPH + O2 <=> 3,5-dichlorocatechol + H2O + NADP(+)","pmd":15.995}
{"X":3446,"KEGG":"R03998","RHEA_ID":16000,"DIRECTION":"BI","MASTER_ID":15997,"compounds":"anthraniloyl-CoA + 2 H(+) + 2 NADH + O2 <=> 2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NAD(+)","pmd":239.038}
{"X":3447,"KEGG":"R03998","RHEA_ID":16000,"DIRECTION":"BI","MASTER_ID":15997,"compounds":"anthraniloyl-CoA + 2 H(+) + 2 NADH + O2 <=> 2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NAD(+)","pmd":18.011}
{"X":3448,"KEGG":"R03999","RHEA_ID":15996,"DIRECTION":"BI","MASTER_ID":15993,"compounds":"anthraniloyl-CoA + 2 H(+) + 2 NADPH + O2 <=> 2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NADP(+)","pmd":159.072}
{"X":3449,"KEGG":"R03999","RHEA_ID":15996,"DIRECTION":"BI","MASTER_ID":15993,"compounds":"anthraniloyl-CoA + 2 H(+) + 2 NADPH + O2 <=> 2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NADP(+)","pmd":18.011}
{"X":3450,"KEGG":"R04000","RHEA_ID":42079,"DIRECTION":"BI","MASTER_ID":42076,"compounds":"2-hydroxyglutarate + acetyl-CoA <=> 2-hydroxyglutaryl-CoA + acetate","pmd":749.105}
{"X":3451,"KEGG":"R04000","RHEA_ID":42079,"DIRECTION":"BI","MASTER_ID":42076,"compounds":"2-hydroxyglutarate + acetyl-CoA <=> 2-hydroxyglutaryl-CoA + acetate","pmd":88.016}
{"X":3452,"KEGG":"R04001","RHEA_ID":10679,"DIRECTION":"BI","MASTER_ID":10676,"ecocyc":"RXN-13163","metacyc":"RXN-13163","compounds":"(2R,3S)-3-isopropylmalate <=> 2-isopropylmaleate + H2O","pmd":18.011}
{"X":3453,"KEGG":"R04002","RHEA_ID":24159,"DIRECTION":"BI","MASTER_ID":24156,"compounds":"2-methylpropanoate + ATP <=> 2-methylpropanoyl phosphate + ADP","pmd":79.966}
{"X":3454,"KEGG":"R04003","RHEA_ID":22871,"DIRECTION":"BI","MASTER_ID":22868,"metacyc":"S-CARBOXYMETHYLCYSTEINE-SYNTHASE-RXN","compounds":"3-chloro-L-alanine + thioglycolate <=> chloride + H(+) + S-carboxymethyl-L-cysteine","pmd":56.017}
{"X":3455,"KEGG":"R04010","RHEA_ID":10007,"DIRECTION":"BI","MASTER_ID":10004,"compounds":"benzyl isothiocyanate <=> benzyl thiocyanate","pmd":0}
{"X":3456,"KEGG":"R04011","RHEA_ID":35626,"DIRECTION":"BI","MASTER_ID":35623,"compounds":"D-glutamate + D-glutamine <=> D-gamma-glutamyl-D-glutamate + NH4(+)"}
{"X":3457,"KEGG":"R04013","RHEA_ID":11339,"DIRECTION":"BI","MASTER_ID":11336,"compounds":"(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine <=> deacetoxyvindoline + H(+) + S-adenosyl-L-homocysteine","pmd":0.083}
{"X":3458,"KEGG":"R04014","RHEA_ID":30122,"DIRECTION":"BI","MASTER_ID":30119,"compounds":"dodecanoyl-[ACP] + H2O <=> dodecanoate + H(+) + holo-[ACP]"}
{"X":3459,"KEGG":"R04015","RHEA_ID":20628,"DIRECTION":"BI","MASTER_ID":20625,"metacyc":"CYTOCHROME-C3-HYDROGENASE-RXN","compounds":"2 [Fe(III)-cytochrome c3] + H2 <=> 2 [Fe(II)-cytochrome c3] + 2 H(+)"}
{"X":3460,"KEGG":"R04016","RHEA_ID":60063,"DIRECTION":"BI","MASTER_ID":60060,"compounds":"a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose <=> alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP","pmd":162.053}
{"X":3461,"KEGG":"R04017","RHEA_ID":20616,"DIRECTION":"BI","MASTER_ID":20613,"metacyc":"GALACTOSYLCERAMIDE-SULFOTRANSFERASE-RXN","compounds":"3'-phosphoadenylyl sulfate + a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine <=> adenosine 3',5'-bisphosphate + H(+) + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine","pmd":79.957}
{"X":3462,"KEGG":"R04022","RHEA_ID":14872,"DIRECTION":"BI","MASTER_ID":14869,"metacyc":"2.3.1.100-RXN","compounds":"an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O <=> acetate + an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative"}
{"X":3463,"KEGG":"R04023","RHEA_ID":11427,"DIRECTION":"BI","MASTER_ID":11424,"metacyc":"2.7.11.7-RXN","compounds":"[myosin heavy-chain]-L-threonine + ATP <=> [myosin heavy-chain]-O-phospho-L-threonine + ADP + H(+)","pmd":79.966}
{"X":3464,"KEGG":"R04026","RHEA_ID":24938,"DIRECTION":"BI","MASTER_ID":24935,"compounds":"H2O + imidazol-4-one <=> N-formimidoylglycine"}
{"X":3465,"KEGG":"R04028","RHEA_ID":16892,"DIRECTION":"BI","MASTER_ID":16889,"metacyc":"2.6.1.65-RXN","compounds":"2-oxoglutarate + 6-acetamido-3-aminohexanoate <=> 6-acetamido-3-oxohexanoate + L-glutamate","pmd":1.032}
{"X":3466,"KEGG":"R04029","RHEA_ID":42507,"DIRECTION":"BI","MASTER_ID":42504,"metacyc":"ACETCAPR-RXN","compounds":"2-oxoglutarate + N(6)-acetyl-L-lysine <=> 6-acetamido-2-oxohexanoate + L-glutamate","pmd":1.032}
{"X":3467,"KEGG":"R04030","RHEA_ID":17012,"DIRECTION":"BI","MASTER_ID":17009,"compounds":"2-succinylbenzoate + ATP + CoA <=> 2-succinylbenzoyl-CoA + AMP + diphosphate","pmd":159.933}
{"X":3468,"KEGG":"R04030","RHEA_ID":17012,"DIRECTION":"BI","MASTER_ID":17009,"compounds":"2-succinylbenzoate + ATP + CoA <=> 2-succinylbenzoyl-CoA + AMP + diphosphate","pmd":125.01}
{"X":3469,"KEGG":"R04030","RHEA_ID":17012,"DIRECTION":"BI","MASTER_ID":17009,"compounds":"2-succinylbenzoate + ATP + CoA <=> 2-succinylbenzoyl-CoA + AMP + diphosphate","pmd":204.042}
{"X":3470,"KEGG":"R04031","RHEA_ID":10199,"DIRECTION":"BI","MASTER_ID":10196,"compounds":"(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate <=> 2-succinylbenzoate + H2O","pmd":18.011}
{"X":3471,"KEGG":"R04033","RHEA_ID":12179,"DIRECTION":"BI","MASTER_ID":12176,"compounds":"phenylethanolamine + S-adenosyl-L-methionine <=> H(+) + N-methylphenylethanolamine + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":3472,"KEGG":"R04035","RHEA_ID":22831,"DIRECTION":"BI","MASTER_ID":22828,"compounds":"1-(5-phospho-beta-D-ribosyl)-ATP + H2O <=> 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)","pmd":159.933}
{"X":3473,"KEGG":"R04036","RHEA_ID":10735,"DIRECTION":"BI","MASTER_ID":10732,"compounds":"ATP + firefly D-luciferin + O2 <=> AMP + CO2 + diphosphate + firefly oxyluciferin + hnu","pmd":30.01}
{"X":3474,"KEGG":"R04036","RHEA_ID":10735,"DIRECTION":"BI","MASTER_ID":10732,"compounds":"ATP + firefly D-luciferin + O2 <=> AMP + CO2 + diphosphate + firefly oxyluciferin + hnu","pmd":159.933}
{"X":3475,"KEGG":"R04037","RHEA_ID":20052,"DIRECTION":"BI","MASTER_ID":20049,"compounds":"1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O <=> 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide","pmd":18.01}
{"X":3476,"KEGG":"R04038","RHEA_ID":15288,"DIRECTION":"BI","MASTER_ID":15285,"compounds":"AMP + dimethylallyl diphosphate <=> diphosphate + N(6)-(dimethylallyl)adenosine 5'-phosphate","pmd":169.12}
{"X":3477,"KEGG":"R04038","RHEA_ID":15288,"DIRECTION":"BI","MASTER_ID":15285,"compounds":"AMP + dimethylallyl diphosphate <=> diphosphate + N(6)-(dimethylallyl)adenosine 5'-phosphate","pmd":68.063}
{"X":3478,"KEGG":"R04040","RHEA_ID":16696,"DIRECTION":"BI","MASTER_ID":16693,"compounds":"alpha-pinene oxide <=> (Z)-2-methyl-5-isopropylhexa-2,5-dienal","pmd":0}
{"X":3479,"KEGG":"R04041","RHEA_ID":15848,"DIRECTION":"BI","MASTER_ID":15845,"compounds":"4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n UDP-alpha-D-glucose <=> 4-O-{[(2R)-2-alpha-D-glucosyl-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n H(+) + n UDP","pmd":162.053}
{"X":3480,"KEGG":"R04042","RHEA_ID":13568,"DIRECTION":"BI","MASTER_ID":13565,"compounds":"4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-glycerol <=> 4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n CMP + n H(+)","pmd":154.003}
{"X":3481,"KEGG":"R04043","RHEA_ID":11555,"DIRECTION":"BI","MASTER_ID":11552,"compounds":"a 1-O-alkyl-2-acetyl-sn-glycerol + H2O <=> 1-O-alkyl-sn-glycerol + acetate + H(+)"}
{"X":3482,"KEGG":"R04044","RHEA_ID":36258,"DIRECTION":"BI","MASTER_ID":36255,"compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 1-O-(1,2-saturated-alkyl)-sn-glycerol + O2 <=> (6R)-L-erythro-6,7-dihydrobiopterin + a 1-(1-hydroxyalkyl)-sn-glycerol + H2O"}
{"X":3483,"KEGG":"R04046","RHEA_ID":13112,"DIRECTION":"BI","MASTER_ID":13109,"compounds":"2-acetamidofluorene + H2O + NAD(+) <=> H(+) + N-hydroxy-2-acetamidofluorene + NADH","pmd":15.995}
{"X":3484,"KEGG":"R04046","RHEA_ID":13112,"DIRECTION":"BI","MASTER_ID":13109,"compounds":"2-acetamidofluorene + H2O + NAD(+) <=> H(+) + N-hydroxy-2-acetamidofluorene + NADH","pmd":425.022}
{"X":3485,"KEGG":"R04047","RHEA_ID":13116,"DIRECTION":"BI","MASTER_ID":13113,"compounds":"2-acetamidofluorene + H2O + NADP(+) <=> H(+) + N-hydroxy-2-acetamidofluorene + NADPH","pmd":15.995}
{"X":3486,"KEGG":"R04047","RHEA_ID":13116,"DIRECTION":"BI","MASTER_ID":13113,"compounds":"2-acetamidofluorene + H2O + NADP(+) <=> H(+) + N-hydroxy-2-acetamidofluorene + NADPH","pmd":504.989}
{"X":3487,"KEGG":"R04049","RHEA_ID":12163,"DIRECTION":"BI","MASTER_ID":12160,"compounds":"2-deoxy-D-gluconate + NAD(+) <=> 3-dehydro-2-deoxy-D-gluconate + H(+) + NADH","pmd":2.016}
{"X":3488,"KEGG":"R04049","RHEA_ID":12163,"DIRECTION":"BI","MASTER_ID":12160,"compounds":"2-deoxy-D-gluconate + NAD(+) <=> 3-dehydro-2-deoxy-D-gluconate + H(+) + NADH","pmd":486.069}
{"X":3489,"KEGG":"R04050","RHEA_ID":21063,"DIRECTION":"BI","MASTER_ID":21060,"compounds":"3,4-dichloroaniline + malonyl-CoA <=> CoA + N-(3,4-dichlorophenyl)malonamate","pmd":86}
{"X":3490,"KEGG":"R04053","RHEA_ID":20771,"DIRECTION":"BI","MASTER_ID":20768,"compounds":"3-phosphonopyruvate + H(+) <=> CO2 + phosphonoacetaldehyde","pmd":43.99}
{"X":3491,"KEGG":"R04055","RHEA_ID":16900,"DIRECTION":"BI","MASTER_ID":16897,"compounds":"a 3beta-hydroxysteroid + a triacylglycerol <=> a 3beta-hydroxysteroid ester + a diacylglycerol"}
{"X":3492,"KEGG":"R04056","RHEA_ID":22931,"DIRECTION":"BI","MASTER_ID":22928,"metacyc":"4-ACETAMIDOBUTYRYL-COA-DEACETYLASE-RXN","compounds":"4-acetamidobutanoyl-CoA + H2O <=> 4-aminobutanoyl-CoA + acetate","pmd":42.01}
{"X":3493,"KEGG":"R04057","RHEA_ID":23499,"DIRECTION":"BI","MASTER_ID":23496,"compounds":"5-hydroxypentanoate + acetyl-CoA <=> 5-hydroxy-pentanoyl-CoA + acetate","pmd":58.042}
{"X":3494,"KEGG":"R04057","RHEA_ID":23499,"DIRECTION":"BI","MASTER_ID":23496,"compounds":"5-hydroxypentanoate + acetyl-CoA <=> 5-hydroxy-pentanoyl-CoA + acetate","pmd":749.105}
{"X":3495,"KEGG":"R04058","RHEA_ID":23655,"DIRECTION":"BI","MASTER_ID":23652,"metacyc":"GLUTAMINYL-PEPTIDE-CYCLOTRANSFERASE-RXN","compounds":"N-terminal L-glutaminyl-[peptide] <=> N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+)"}
{"X":3496,"KEGG":"R04059","RHEA_ID":22187,"DIRECTION":"BI","MASTER_ID":22184,"compounds":"(+-)-trans-acenaphthene-1,2-diol + 2 NADP(+) <=> acenaphthene-1,2-dione + 2 H(+) + 2 NADPH","pmd":562.047}
{"X":3497,"KEGG":"R04059","RHEA_ID":22187,"DIRECTION":"BI","MASTER_ID":22184,"compounds":"(+-)-trans-acenaphthene-1,2-diol + 2 NADP(+) <=> acenaphthene-1,2-dione + 2 H(+) + 2 NADPH","pmd":4.031}
{"X":3498,"KEGG":"R04060","RHEA_ID":11979,"DIRECTION":"BI","MASTER_ID":11976,"compounds":"anhydrotetracycline + H(+) + NADPH + O2 <=> 5a,11a-dehydrotetracycline + H2O + NADP(+)","pmd":15.995}
{"X":3499,"KEGG":"R04060","RHEA_ID":11979,"DIRECTION":"BI","MASTER_ID":11976,"compounds":"anhydrotetracycline + H(+) + NADPH + O2 <=> 5a,11a-dehydrotetracycline + H2O + NADP(+)","pmd":302.953}
{"X":3500,"KEGG":"R04061","RHEA_ID":19444,"DIRECTION":"BI","MASTER_ID":19441,"compounds":"benzene-1,2,4-triol + O2 <=> 3-hydroxy-cis,cis-muconate + 2 H(+)","pmd":31.99}
{"X":3501,"KEGG":"R04061","RHEA_ID":35598,"DIRECTION":"BI","MASTER_ID":35595,"compounds":"benzene-1,2,4-triol + O2 <=> 2 H(+) + maleylacetate","pmd":31.99}
{"X":3502,"KEGG":"R04062","RHEA_ID":21559,"DIRECTION":"BI","MASTER_ID":21556,"compounds":"[calmodulin]-L-lysine + S-adenosyl-L-methionine <=> [calmodulin]-N(6)-methyl-L-lysine + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":3503,"KEGG":"R04063","RHEA_ID":22763,"DIRECTION":"BI","MASTER_ID":22760,"compounds":"Cypridina luciferin + O2 <=> CO2 + hnu + oxidized Cypridina luciferin","pmd":12}
{"X":3504,"KEGG":"R04065","RHEA_ID":31062,"DIRECTION":"BI","MASTER_ID":31059,"compounds":"H2O + imidazole-4-acetaldehyde + NAD(+) <=> 2 H(+) + imidazole-4-acetate + NADH","pmd":15.995}
{"X":3505,"KEGG":"R04065","RHEA_ID":31062,"DIRECTION":"BI","MASTER_ID":31059,"compounds":"H2O + imidazole-4-acetaldehyde + NAD(+) <=> 2 H(+) + imidazole-4-acetate + NADH","pmd":538.074}
{"X":3506,"KEGG":"R04066","RHEA_ID":19428,"DIRECTION":"BI","MASTER_ID":19425,"compounds":"H(+) + imidazole-4-acetate + NADH + O2 <=> 5-hydroxyimidazole-4-acetate + H2O + NAD(+)","pmd":15.995}
{"X":3507,"KEGG":"R04066","RHEA_ID":19428,"DIRECTION":"BI","MASTER_ID":19425,"compounds":"H(+) + imidazole-4-acetate + NADH + O2 <=> 5-hydroxyimidazole-4-acetate + H2O + NAD(+)","pmd":523.087}
{"X":3508,"KEGG":"R04068","RHEA_ID":16488,"DIRECTION":"BI","MASTER_ID":16485,"compounds":"5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + imidazole-4-acetate <=> 1-(5-phosphoribosyl)imidazole-4-acetate + ADP + diphosphate + H(+) + phosphate","pmd":79.966}
{"X":3509,"KEGG":"R04068","RHEA_ID":16488,"DIRECTION":"BI","MASTER_ID":16485,"compounds":"5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + imidazole-4-acetate <=> 1-(5-phosphoribosyl)imidazole-4-acetate + ADP + diphosphate + H(+) + phosphate","pmd":37.078}
{"X":3510,"KEGG":"R04068","RHEA_ID":16488,"DIRECTION":"BI","MASTER_ID":16485,"compounds":"5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + imidazole-4-acetate <=> 1-(5-phosphoribosyl)imidazole-4-acetate + ADP + diphosphate + H(+) + phosphate","pmd":212.009}
{"X":3511,"KEGG":"R04070","RHEA_ID":20168,"DIRECTION":"BI","MASTER_ID":20165,"compounds":"H2O + N(5)-acyl-L-ornithine ester <=> an alcohol + H(+) + N(5)-acyl-L-ornithine"}
{"X":3512,"KEGG":"R04071","RHEA_ID":23275,"DIRECTION":"BI","MASTER_ID":23272,"metacyc":"CYTOKININ-7-BETA-GLUCOSYLTRANSFERASE-RXN","compounds":"an N(6)-alkylaminopurine + UDP-alpha-D-glucose <=> an N(6)-alkylamino-7-beta-D-glucosylpurine + H(+) + UDP","pmd":162.053}
{"X":3513,"KEGG":"R04072","RHEA_ID":17380,"DIRECTION":"BI","MASTER_ID":17377,"compounds":"dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] <=> 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + dolichyl phosphate + H(+)"}
{"X":3514,"KEGG":"R04073","RHEA_ID":11511,"DIRECTION":"BI","MASTER_ID":11508,"compounds":"2-oxoglutarate + L-aspartyl-[protein] + O2 <=> 3-hydroxy-L-aspartyl-[protein] + CO2 + succinate","pmd":27.995}
{"X":3515,"KEGG":"R04074","RHEA_ID":11823,"DIRECTION":"BI","MASTER_ID":11820,"metacyc":"RXN-11372","compounds":"diphthamide-[translation elongation factor 2] + NAD(+) <=> H(+) + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2] + nicotinamide","pmd":542.069}
{"X":3516,"KEGG":"R04076","RHEA_ID":49299,"DIRECTION":"BI","MASTER_ID":49296,"compounds":"keto-L-sorbose(out) + N(pros)-phospho-L-histidyl-[protein] <=> L-histidyl-[protein] + L-sorbose 1-phosphate(in)","pmd":79.966}
{"X":3517,"KEGG":"R04077","RHEA_ID":22539,"DIRECTION":"BI","MASTER_ID":22536,"compounds":"(S)-tetrahydrocolumbamine + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + tetrahydropalmatine","pmd":14.016}
{"X":3518,"KEGG":"R04078","RHEA_ID":18060,"DIRECTION":"BI","MASTER_ID":18057,"compounds":"O2 + Watasenia luciferin <=> CO2 + hnu + oxidized Watasenia luciferin","pmd":12}
{"X":3519,"KEGG":"R04080","RHEA_ID":14528,"DIRECTION":"BI","MASTER_ID":14525,"compounds":"A + beta-cyclopiazonate <=> AH2 + alpha-cyclopiazonate","pmd":2.016}
{"X":3520,"KEGG":"R04082","RHEA_ID":12888,"DIRECTION":"BI","MASTER_ID":12885,"compounds":"GDP-alpha-D-mannose + queuosine 5'-phosphate in tRNA(Asp) <=> beta-D-mannosyl-5''-O-queuosine 5'-phosphate in tRNA(Asp) + GDP + H(+)","pmd":162.053}
{"X":3521,"KEGG":"R04088","RHEA_ID":25196,"DIRECTION":"BI","MASTER_ID":25193,"compounds":"(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+) <=> 3-methylcatechol + H(+) + NADH","pmd":540.064}
{"X":3522,"KEGG":"R04088","RHEA_ID":25196,"DIRECTION":"BI","MASTER_ID":25193,"compounds":"(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+) <=> 3-methylcatechol + H(+) + NADH","pmd":2.016}
{"X":3523,"KEGG":"R04089","RHEA_ID":48999,"DIRECTION":"BI","MASTER_ID":48996,"compounds":"3-methylcatechol + O2 <=> 2-hydroxy-6-oxo-2,4-heptadienoate + H(+)","pmd":31.99}
{"X":3524,"KEGG":"R04090","RHEA_ID":21867,"DIRECTION":"BI","MASTER_ID":21864,"compounds":"an S-(2-hydroxyacyl)glutathione + H2O <=> a 2-hydroxy carboxylate + glutathione + H(+)"}
{"X":3525,"KEGG":"R04091","RHEA_ID":12696,"DIRECTION":"BI","MASTER_ID":12693,"compounds":"3,4-dihydroxypyridine + O-acetyl-L-serine <=> 3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate + H(+)","pmd":52.019}
{"X":3526,"KEGG":"R04091","RHEA_ID":12696,"DIRECTION":"BI","MASTER_ID":12693,"compounds":"3,4-dihydroxypyridine + O-acetyl-L-serine <=> 3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate + H(+)","pmd":88.04}
{"X":3527,"KEGG":"R04093","RHEA_ID":23159,"DIRECTION":"BI","MASTER_ID":23156,"compounds":"(E)-(indol-3-yl)acetaldehyde oxime <=> (indol-3-yl)acetonitrile + H2O","pmd":18.011}
{"X":3528,"KEGG":"R04095","RHEA_ID":31066,"DIRECTION":"BI","MASTER_ID":31063,"metacyc":"RXN-14264","compounds":"3-methylbutanoyl-CoA + FAD + H(+) <=> 3-methylbut-2-enoyl-CoA + FADH2","pmd":2.016}
{"X":3529,"KEGG":"R04096","RHEA_ID":12279,"DIRECTION":"BI","MASTER_ID":12276,"ecocyc":"RXN0-2301","compounds":"3-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> 3-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]","pmd":2.016}
{"X":3530,"KEGG":"R04099","RHEA_ID":20819,"DIRECTION":"BI","MASTER_ID":20816,"metacyc":"1.1.1.230-RXN","compounds":"3alpha-hydroxyglycyrrhetinate + NADP(+) <=> 3-oxoglycyrrhetinate + H(+) + NADPH","pmd":275.759}
{"X":3531,"KEGG":"R04099","RHEA_ID":20819,"DIRECTION":"BI","MASTER_ID":20816,"metacyc":"1.1.1.230-RXN","compounds":"3alpha-hydroxyglycyrrhetinate + NADP(+) <=> 3-oxoglycyrrhetinate + H(+) + NADPH","pmd":2.016}
{"X":3532,"KEGG":"R04100","RHEA_ID":23719,"DIRECTION":"BI","MASTER_ID":23716,"ecocyc":"RXN-7931","metacyc":"RXN-7931","compounds":"(3Z)-dodecenoyl-CoA <=> (2E)-dodecenoyl-CoA","pmd":0}
{"X":3533,"KEGG":"R04101","RHEA_ID":14856,"DIRECTION":"BI","MASTER_ID":14853,"compounds":"4-chlorobenzoyl-CoA + H2O <=> 4-hydroxybenzoyl-CoA + chloride + H(+)","pmd":17.966}
{"X":3534,"KEGG":"R04102","RHEA_ID":34418,"DIRECTION":"BI","MASTER_ID":34415,"compounds":"(1R,4R)-bornane-2,5-dione + FMNH2 + O2 <=> (1R,4R)-5-oxo-1,2-campholide + FMN + H(+) + H2O","pmd":2.016}
{"X":3535,"KEGG":"R04102","RHEA_ID":34418,"DIRECTION":"BI","MASTER_ID":34415,"compounds":"(1R,4R)-bornane-2,5-dione + FMNH2 + O2 <=> (1R,4R)-5-oxo-1,2-campholide + FMN + H(+) + H2O","pmd":15.995}
{"X":3536,"KEGG":"R04104","RHEA_ID":21087,"DIRECTION":"BI","MASTER_ID":21084,"compounds":"chondroitin 4'-sulfate <=> dermatan 4'-sulfate"}
{"X":3537,"KEGG":"R04105","RHEA_ID":24355,"DIRECTION":"BI","MASTER_ID":24352,"compounds":"ethyl (R)-3-hydroxyhexanoate + NADP(+) <=> ethyl 3-oxohexanoate + H(+) + NADPH","pmd":2.016}
{"X":3538,"KEGG":"R04105","RHEA_ID":24355,"DIRECTION":"BI","MASTER_ID":24352,"compounds":"ethyl (R)-3-hydroxyhexanoate + NADP(+) <=> ethyl 3-oxohexanoate + H(+) + NADPH","pmd":585.989}
{"X":3539,"KEGG":"R04106","RHEA_ID":18272,"DIRECTION":"BI","MASTER_ID":18269,"compounds":"ethyl (S)-3-hydroxyhexanoate + NADP(+) <=> ethyl 3-oxohexanoate + H(+) + NADPH","pmd":585.989}
{"X":3540,"KEGG":"R04106","RHEA_ID":18272,"DIRECTION":"BI","MASTER_ID":18269,"compounds":"ethyl (S)-3-hydroxyhexanoate + NADP(+) <=> ethyl 3-oxohexanoate + H(+) + NADPH","pmd":2.016}
{"X":3541,"KEGG":"R04109","RHEA_ID":12347,"DIRECTION":"BI","MASTER_ID":12344,"compounds":"(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) <=> H(+) + L-glutamyl-tRNA(Glu) + NADPH","pmd":614.033}
{"X":3542,"KEGG":"R04111","RHEA_ID":49303,"DIRECTION":"BI","MASTER_ID":49300,"compounds":"D-maltose(out) + N(pros)-phospho-L-histidyl-[protein] <=> alpha-maltose 6'-phosphate(in) + L-histidyl-[protein]","pmd":79.966}
{"X":3543,"KEGG":"R04112","RHEA_ID":31086,"DIRECTION":"BI","MASTER_ID":31083,"metacyc":"RXN-14267","compounds":"H2O + N-acetyl-D-muramoyl-L-alanine <=> L-alanine + N-acetyl-D-muramate","pmd":71.037}
{"X":3544,"KEGG":"R04113","RHEA_ID":14424,"DIRECTION":"BI","MASTER_ID":14421,"compounds":"H2O + N(2)-benzoyl-D-arginine-4-nitroanilide <=> 4-nitroaniline + H(+) + N(2)-benzoyl-D-arginine","pmd":120.032}
{"X":3545,"KEGG":"R04115","RHEA_ID":11835,"DIRECTION":"BI","MASTER_ID":11832,"compounds":"(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+) <=> H(+) + NADH + naphthalene-1,2-diol","pmd":2.016}
{"X":3546,"KEGG":"R04115","RHEA_ID":11835,"DIRECTION":"BI","MASTER_ID":11832,"compounds":"(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+) <=> H(+) + NADH + naphthalene-1,2-diol","pmd":504.064}
{"X":3547,"KEGG":"R04117","RHEA_ID":27313,"DIRECTION":"BI","MASTER_ID":27310,"compounds":"naphthalene-1,2-diol + O2 <=> 2-hydroxychromene-2-carboxylate + H(+)","pmd":31.99}
{"X":3548,"KEGG":"R04118","RHEA_ID":22291,"DIRECTION":"BI","MASTER_ID":22288,"compounds":"an oligoglycosyl-(1->4)-glucosyl-(1<->1)-ceramide + H2O <=> an oligoglycosyl-(1->4)-beta-D-glucose + N-acyl-sphingoid base"}
{"X":3549,"KEGG":"R04119","RHEA_ID":21319,"DIRECTION":"BI","MASTER_ID":21316,"compounds":"H2O + phorbol 12,13-dibutanoate <=> butanoate + H(+) + phorbol 13-butanoate","pmd":70.042}
{"X":3550,"KEGG":"R04120","RHEA_ID":14220,"DIRECTION":"BI","MASTER_ID":14217,"compounds":"[thioredoxin]-disulfide + H2O + L-methionyl-[protein] <=> [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]"}
{"X":3551,"KEGG":"R04122","RHEA_ID":17152,"DIRECTION":"BI","MASTER_ID":17149,"compounds":"an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] <=> an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":3552,"KEGG":"R04123","RHEA_ID":13844,"DIRECTION":"BI","MASTER_ID":13841,"compounds":"[transferrin[Fe(II)2]] + H(+) + NAD(+) <=> [transferrin[Fe(III)2]] + NADH"}
{"X":3553,"KEGG":"R04125","RHEA_ID":16948,"DIRECTION":"BI","MASTER_ID":16945,"compounds":"(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)","pmd":12}
{"X":3554,"KEGG":"R04126","RHEA_ID":16940,"DIRECTION":"BI","MASTER_ID":16937,"compounds":"1-O-alkyl-sn-glycerol + ATP <=> 1-O-alkyl-sn-glycero-3-phosphate + ADP + H(+)","pmd":79.966}
{"X":3555,"KEGG":"R04127","RHEA_ID":22319,"DIRECTION":"BI","MASTER_ID":22316,"compounds":"13-hydroxydocosanoate + UDP-alpha-D-glucose <=> 13-(beta-D-glucosyloxy)docosanoate + H(+) + UDP","pmd":47.673}
{"X":3556,"KEGG":"R04130","RHEA_ID":16920,"DIRECTION":"BI","MASTER_ID":16917,"compounds":"2,6-dihydroxypyridine + H(+) + NADH + O2 <=> 2,3,6-trihydroxypyridine + H2O + NAD(+)","pmd":538.098}
{"X":3557,"KEGG":"R04130","RHEA_ID":16920,"DIRECTION":"BI","MASTER_ID":16917,"compounds":"2,6-dihydroxypyridine + H(+) + NADH + O2 <=> 2,3,6-trihydroxypyridine + H2O + NAD(+)","pmd":15.995}
{"X":3558,"KEGG":"R04133","RHEA_ID":14400,"DIRECTION":"BI","MASTER_ID":14397,"compounds":"(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+) <=> (4Z)-2-oxohept-4-enedioate + CO2","pmd":43.99}
{"X":3559,"KEGG":"R04135","RHEA_ID":14076,"DIRECTION":"BI","MASTER_ID":14073,"compounds":"3-hydroxy-L-glutamate + H(+) <=> 4-amino-3-hydroxybutanoate + CO2","pmd":43.99}
{"X":3560,"KEGG":"R04136","RHEA_ID":22343,"DIRECTION":"BI","MASTER_ID":22340,"compounds":"3-hydroxybenzyl alcohol + NADP(+) <=> 3-hydroxybenzaldehyde + H(+) + NADPH","pmd":622.047}
{"X":3561,"KEGG":"R04136","RHEA_ID":22343,"DIRECTION":"BI","MASTER_ID":22340,"compounds":"3-hydroxybenzyl alcohol + NADP(+) <=> 3-hydroxybenzaldehyde + H(+) + NADPH","pmd":2.016}
{"X":3562,"KEGG":"R04137","RHEA_ID":31082,"DIRECTION":"BI","MASTER_ID":31079,"compounds":"3-hydroxyisovaleryl-CoA <=> 3-methylbut-2-enoyl-CoA + H2O","pmd":18.01}
{"X":3563,"KEGG":"R04138","RHEA_ID":13592,"DIRECTION":"BI","MASTER_ID":13589,"compounds":"3-methylbut-2-enoyl-CoA + ATP + hydrogencarbonate <=> ADP + H(+) + phosphate + trans-3-methylglutaconyl-CoA","pmd":43.99}
{"X":3564,"KEGG":"R04138","RHEA_ID":13592,"DIRECTION":"BI","MASTER_ID":13589,"compounds":"3-methylbut-2-enoyl-CoA + ATP + hydrogencarbonate <=> ADP + H(+) + phosphate + trans-3-methylglutaconyl-CoA","pmd":79.966}
{"X":3565,"KEGG":"R04139","RHEA_ID":19588,"DIRECTION":"BI","MASTER_ID":19585,"metacyc":"1.1.1.52-RXN","compounds":"lithocholate + NAD(+) <=> 3-oxo-5beta-cholan-24-oate + H(+) + NADH","pmd":289.835}
{"X":3566,"KEGG":"R04139","RHEA_ID":19588,"DIRECTION":"BI","MASTER_ID":19585,"metacyc":"1.1.1.52-RXN","compounds":"lithocholate + NAD(+) <=> 3-oxo-5beta-cholan-24-oate + H(+) + NADH","pmd":2.016}
{"X":3567,"KEGG":"R04140","RHEA_ID":20660,"DIRECTION":"BI","MASTER_ID":20657,"metacyc":"3.5.5.5-RXN","compounds":"4-chlorophenylacetonitrile + 2 H2O <=> 4-chlorophenylacetate + NH4(+)","pmd":18.995}
{"X":3568,"KEGG":"R04141","RHEA_ID":12211,"DIRECTION":"BI","MASTER_ID":12208,"compounds":"4-methylumbelliferyl acetate + H2O <=> 4-methylumbelliferone + acetate + H(+)","pmd":42.011}
{"X":3569,"KEGG":"R04142","RHEA_ID":42511,"DIRECTION":"BI","MASTER_ID":42508,"compounds":"6-acetamido-2-oxohexanoate + H2O + NAD(+) <=> 5-acetamidopentanoate + CO2 + H(+) + NADH","pmd":478.04}
{"X":3570,"KEGG":"R04142","RHEA_ID":42511,"DIRECTION":"BI","MASTER_ID":42508,"compounds":"6-acetamido-2-oxohexanoate + H2O + NAD(+) <=> 5-acetamidopentanoate + CO2 + H(+) + NADH","pmd":27.995}
{"X":3571,"KEGG":"R04143","RHEA_ID":22315,"DIRECTION":"BI","MASTER_ID":22312,"compounds":"ATP + S-methyl-5-thio-D-ribose <=> ADP + H(+) + S-methyl-5-thio-alpha-D-ribose 1-phosphate","pmd":79.966}
{"X":3572,"KEGG":"R04144","RHEA_ID":17456,"DIRECTION":"BI","MASTER_ID":17453,"compounds":"5-phospho-D-ribosylamine + ATP + glycine <=> ADP + H(+) + N(1)-(5-phospho-D-ribosyl)glycinamide + phosphate","pmd":57.022}
{"X":3573,"KEGG":"R04144","RHEA_ID":17456,"DIRECTION":"BI","MASTER_ID":17453,"compounds":"5-phospho-D-ribosylamine + ATP + glycine <=> ADP + H(+) + N(1)-(5-phospho-D-ribosyl)glycinamide + phosphate","pmd":79.966}
{"X":3574,"KEGG":"R04145","RHEA_ID":24315,"DIRECTION":"BI","MASTER_ID":24312,"compounds":"L-lysyl-[cytochrome c] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl-[cytochrome c] + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":3575,"KEGG":"R04147","RHEA_ID":20036,"DIRECTION":"BI","MASTER_ID":20033,"metacyc":"5.1.1.17-RXN","compounds":"isopenicillin N <=> penicillin N","pmd":0}
{"X":3576,"KEGG":"R04148","RHEA_ID":11199,"DIRECTION":"BI","MASTER_ID":11196,"compounds":"5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide <=> alpha-ribazole 5'-phosphate + H(+) + nicotinate","pmd":22.045}
{"X":3577,"KEGG":"R04148","RHEA_ID":11199,"DIRECTION":"BI","MASTER_ID":11196,"compounds":"5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide <=> alpha-ribazole 5'-phosphate + H(+) + nicotinate","pmd":23.052}
{"X":3578,"KEGG":"R04150","RHEA_ID":15528,"DIRECTION":"BI","MASTER_ID":15525,"compounds":"2-succinylbenzoyl-CoA <=> 1,4-dihydroxy-2-naphthoate + CoA","pmd":204.042}
{"X":3579,"KEGG":"R04151","RHEA_ID":16256,"DIRECTION":"BI","MASTER_ID":16253,"metacyc":"1.3.1.49-RXN","compounds":"(3S,4R)-3,4-dihydrophenanthrene-3,4-diol + NAD(+) <=> H(+) + NADH + phenanthrene-3,4-diol","pmd":2.016}
{"X":3580,"KEGG":"R04151","RHEA_ID":16256,"DIRECTION":"BI","MASTER_ID":16253,"metacyc":"1.3.1.49-RXN","compounds":"(3S,4R)-3,4-dihydrophenanthrene-3,4-diol + NAD(+) <=> H(+) + NADH + phenanthrene-3,4-diol","pmd":454.049}
{"X":3581,"KEGG":"R04152","RHEA_ID":17024,"DIRECTION":"BI","MASTER_ID":17021,"metacyc":"2.6.1.37-RXN","compounds":"(2-aminoethyl)phosphonate + pyruvate <=> L-alanine + phosphonoacetaldehyde","pmd":1.032}
{"X":3582,"KEGG":"R04153","RHEA_ID":22791,"DIRECTION":"BI","MASTER_ID":22788,"metacyc":"2.1.1.3-RXN","compounds":"dimethylsulfonioacetate + L-homocysteine <=> (methylsulfanyl)acetate + H(+) + L-methionine","pmd":15.023}
{"X":3583,"KEGG":"R04153","RHEA_ID":22791,"DIRECTION":"BI","MASTER_ID":22788,"metacyc":"2.1.1.3-RXN","compounds":"dimethylsulfonioacetate + L-homocysteine <=> (methylsulfanyl)acetate + H(+) + L-methionine","pmd":14.016}
{"X":3584,"KEGG":"R04154","RHEA_ID":18100,"DIRECTION":"BI","MASTER_ID":18097,"compounds":"pteridine-2,4,6,7-tetrol <=> H(+) + xanthine-8-carboxylate","pmd":0}
{"X":3585,"KEGG":"R04157","RHEA_ID":14292,"DIRECTION":"BI","MASTER_ID":14289,"compounds":"a dicarboxylate + ATP + CoA <=> AMP + diphosphate + omega-dicarboxyl-CoA","pmd":420.052}
{"X":3586,"KEGG":"R04157","RHEA_ID":14292,"DIRECTION":"BI","MASTER_ID":14289,"compounds":"a dicarboxylate + ATP + CoA <=> AMP + diphosphate + omega-dicarboxyl-CoA","pmd":159.933}
{"X":3587,"KEGG":"R04158","RHEA_ID":23407,"DIRECTION":"BI","MASTER_ID":23404,"compounds":"all-trans-geranylgeranyl diphosphate + sn-glycerol 1-phosphate <=> diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate","pmd":272.25}
{"X":3588,"KEGG":"R04158","RHEA_ID":23407,"DIRECTION":"BI","MASTER_ID":23404,"compounds":"all-trans-geranylgeranyl diphosphate + sn-glycerol 1-phosphate <=> diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate","pmd":5.93}
{"X":3589,"KEGG":"R04159","RHEA_ID":23907,"DIRECTION":"BI","MASTER_ID":23904,"ecocyc":"GAMMA-GLUTAMYLTRANSFERASE-RXN","metacyc":"GAMMA-GLUTAMYLTRANSFERASE-RXN","compounds":"an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] <=> 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]"}
{"X":3590,"KEGG":"R04162","RHEA_ID":36242,"DIRECTION":"BI","MASTER_ID":36239,"compounds":"1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O <=> 1-O-alkyl-2-acyl-sn-glycerol + phosphate"}
{"X":3591,"KEGG":"R04165","RHEA_ID":17864,"DIRECTION":"BI","MASTER_ID":17861,"compounds":"21-hydroxyprogesterone <=> 20-hydroxy-3-oxopregn-4-en-21-al","pmd":0}
{"X":3592,"KEGG":"R04166","RHEA_ID":12587,"DIRECTION":"BI","MASTER_ID":12584,"compounds":"16alpha-hydroxyprogesterone <=> 16,17-didehydroprogesterone + H2O","pmd":18.011}
{"X":3593,"KEGG":"R04167","RHEA_ID":17840,"DIRECTION":"BI","MASTER_ID":17837,"compounds":"2-carboxy-D-arabinitol 1-phosphate + H2O <=> 2-carboxy-D-arabinitol + phosphate","pmd":79.966}
{"X":3594,"KEGG":"R04169","RHEA_ID":10999,"DIRECTION":"BI","MASTER_ID":10996,"compounds":"2-methylpropanal oxime + S-adenosyl-L-methionine <=> 2-methylpropanal O-methyloxime + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":3595,"KEGG":"R04170","RHEA_ID":31078,"DIRECTION":"BI","MASTER_ID":31075,"compounds":"(3S)-hydroxydodecanoyl-CoA <=> (2E)-dodecenoyl-CoA + H2O","pmd":18.011}
{"X":3596,"KEGG":"R04173","RHEA_ID":14332,"DIRECTION":"BI","MASTER_ID":14329,"ecocyc":"PSERTRANSAM-RXN","metacyc":"PSERTRANSAM-RXN","compounds":"2-oxoglutarate + O-phospho-L-serine <=> 3-phosphooxypyruvate + L-glutamate","pmd":1.032}
{"X":3597,"KEGG":"R04175","RHEA_ID":31070,"DIRECTION":"BI","MASTER_ID":31067,"metacyc":"RXN-8172","compounds":"6-amino-2-oxohexanoate <=> Delta(1)-piperideine-2-carboxylate + H2O","pmd":18.011}
{"X":3598,"KEGG":"R04178","RHEA_ID":43439,"DIRECTION":"BI","MASTER_ID":43436,"compounds":"coproporphyrinogen III + 3 O2 <=> coproporphyrin III + 3 H2O2","pmd":6.047}
{"X":3599,"KEGG":"R04179","RHEA_ID":20184,"DIRECTION":"BI","MASTER_ID":20181,"compounds":"alpha-D-mannose derivative + UDP-alpha-D-glucose <=> 6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H(+) + UMP","pmd":242.019}
{"X":3600,"KEGG":"R04180","RHEA_ID":18048,"DIRECTION":"BI","MASTER_ID":18045,"compounds":"6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H2O <=> alpha-D-glucose 1-phosphate + alpha-D-mannose derivative + H(+)"}
{"X":3601,"KEGG":"R04182","RHEA_ID":22167,"DIRECTION":"BI","MASTER_ID":22164,"compounds":"globoside Gb4Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> globoside Forssman (d18:1(4E)) + H(+) + UDP","pmd":203.079}
{"X":3602,"KEGG":"R04185","RHEA_ID":12039,"DIRECTION":"BI","MASTER_ID":12036,"metacyc":"IMILACTDEHYDROG-RXN","compounds":"(S)-3-(imidazol-5-yl)lactate + NAD(+) <=> 3-(imidazol-5-yl)pyruvate + H(+) + NADH","pmd":2.016}
{"X":3603,"KEGG":"R04185","RHEA_ID":12039,"DIRECTION":"BI","MASTER_ID":12036,"metacyc":"IMILACTDEHYDROG-RXN","compounds":"(S)-3-(imidazol-5-yl)lactate + NAD(+) <=> 3-(imidazol-5-yl)pyruvate + H(+) + NADH","pmd":510.079}
{"X":3604,"KEGG":"R04186","RHEA_ID":12043,"DIRECTION":"BI","MASTER_ID":12040,"metacyc":"IMILACTDEHYDROG-RXN","compounds":"(S)-3-(imidazol-5-yl)lactate + NADP(+) <=> 3-(imidazol-5-yl)pyruvate + H(+) + NADPH","pmd":590.045}
{"X":3605,"KEGG":"R04186","RHEA_ID":12043,"DIRECTION":"BI","MASTER_ID":12040,"metacyc":"IMILACTDEHYDROG-RXN","compounds":"(S)-3-(imidazol-5-yl)lactate + NADP(+) <=> 3-(imidazol-5-yl)pyruvate + H(+) + NADPH","pmd":2.016}
{"X":3606,"KEGG":"R04187","RHEA_ID":31074,"DIRECTION":"BI","MASTER_ID":31071,"compounds":"(S)-methylmalonate semialdehyde + L-alanine <=> (S)-3-amino-2-methylpropanoate + pyruvate","pmd":1.032}
{"X":3607,"KEGG":"R04188","RHEA_ID":13996,"DIRECTION":"BI","MASTER_ID":13993,"compounds":"(S)-3-amino-2-methylpropanoate + 2-oxoglutarate <=> 2-methyl-3-oxopropanoate + L-glutamate","pmd":1.032}
{"X":3608,"KEGG":"R04189","RHEA_ID":19536,"DIRECTION":"BI","MASTER_ID":19533,"compounds":"2 H(+) + 2 H2O + N(2)-succinyl-L-arginine <=> CO2 + N(2)-succinyl-L-ornithine + 2 NH4(+)","pmd":42.022}
{"X":3609,"KEGG":"R04190","RHEA_ID":12708,"DIRECTION":"BI","MASTER_ID":12705,"compounds":"[protein]-L-beta-isoaspartate + S-adenosyl-L-methionine <=> [protein]-L-beta-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":3610,"KEGG":"R04191","RHEA_ID":17244,"DIRECTION":"BI","MASTER_ID":17241,"compounds":"an alpha-amino acid ester + H2O <=> an alcohol + an alpha-amino acid + H(+)"}
{"X":3611,"KEGG":"R04192","RHEA_ID":15280,"DIRECTION":"BI","MASTER_ID":15277,"metacyc":"TUBULIN-N-ACETYLTRANSFERASE-RXN","compounds":"acetyl-CoA + L-lysyl-[alpha-tubulin] <=> CoA + H(+) + N(6)-acetyl-L-lysyl-[alpha-tubulin]","pmd":42.011}
{"X":3612,"KEGG":"R04194","RHEA_ID":15748,"DIRECTION":"BI","MASTER_ID":15745,"metacyc":"INULOSUCRASE-RXN","compounds":"[(2->1)-beta-D-fructosyl](n) + sucrose <=> [(2->1)-beta-D-fructosyl](n+1) + D-glucose","pmd":162.053}
{"X":3613,"KEGG":"R04198","RHEA_ID":35326,"DIRECTION":"BI","MASTER_ID":35323,"compounds":"(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) <=> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH","pmd":15.995}
{"X":3614,"KEGG":"R04198","RHEA_ID":35326,"DIRECTION":"BI","MASTER_ID":35323,"compounds":"(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) <=> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH","pmd":477.069}
{"X":3615,"KEGG":"R04199","RHEA_ID":35334,"DIRECTION":"BI","MASTER_ID":35331,"compounds":"(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) <=> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH","pmd":15.995}
{"X":3616,"KEGG":"R04199","RHEA_ID":35334,"DIRECTION":"BI","MASTER_ID":35331,"compounds":"(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) <=> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH","pmd":557.035}
{"X":3617,"KEGG":"R04200","RHEA_ID":24199,"DIRECTION":"BI","MASTER_ID":24196,"compounds":"(2R,4S)-2,4-diaminopentanoate + H2O + NAD(+) <=> (2R)-2-amino-4-oxopentanoate + H(+) + NADH + NH4(+)","pmd":533.059}
{"X":3618,"KEGG":"R04200","RHEA_ID":24199,"DIRECTION":"BI","MASTER_ID":24196,"compounds":"(2R,4S)-2,4-diaminopentanoate + H2O + NAD(+) <=> (2R)-2-amino-4-oxopentanoate + H(+) + NADH + NH4(+)","pmd":1.032}
{"X":3619,"KEGG":"R04201","RHEA_ID":24195,"DIRECTION":"BI","MASTER_ID":24192,"compounds":"(2R,4S)-2,4-diaminopentanoate + H2O + NADP(+) <=> (2R)-2-amino-4-oxopentanoate + H(+) + NADPH + NH4(+)","pmd":613.025}
{"X":3620,"KEGG":"R04201","RHEA_ID":24195,"DIRECTION":"BI","MASTER_ID":24192,"compounds":"(2R,4S)-2,4-diaminopentanoate + H2O + NADP(+) <=> (2R)-2-amino-4-oxopentanoate + H(+) + NADPH + NH4(+)","pmd":1.032}
{"X":3621,"KEGG":"R04202","RHEA_ID":15532,"DIRECTION":"BI","MASTER_ID":15529,"compounds":"bis(2-ethylhexyl)phthalate + H2O <=> 2-ethylhexan-1-ol + 2-ethylhexyl phthalate + H(+)","pmd":112.125}
{"X":3622,"KEGG":"R04203","RHEA_ID":13284,"DIRECTION":"BI","MASTER_ID":13281,"metacyc":"1.1.1.178-RXN","compounds":"(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) <=> 2-methyl-3-oxobutanoyl-CoA + H(+) + NADH","pmd":2.016}
{"X":3623,"KEGG":"R04203","RHEA_ID":13284,"DIRECTION":"BI","MASTER_ID":13281,"metacyc":"1.1.1.178-RXN","compounds":"(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) <=> 2-methyl-3-oxobutanoyl-CoA + H(+) + NADH","pmd":201.035}
{"X":3624,"KEGG":"R04204","RHEA_ID":31122,"DIRECTION":"BI","MASTER_ID":31119,"metacyc":"TIGLYLCOA-HYDROXY-RXN","compounds":"(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA <=> (2E)-2-methylbutenoyl-CoA + H2O","pmd":18.01}
{"X":3625,"KEGG":"R04205","RHEA_ID":12363,"DIRECTION":"BI","MASTER_ID":12360,"compounds":"(2E)-2-methylbutenoyl-CoA + 13-hydroxylupanine <=> 13-(2-methylcrotonoyloxy)lupanine + CoA","pmd":82.042}
{"X":3626,"KEGG":"R04208","RHEA_ID":23035,"DIRECTION":"BI","MASTER_ID":23032,"compounds":"2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate","pmd":79.966}
{"X":3627,"KEGG":"R04208","RHEA_ID":23035,"DIRECTION":"BI","MASTER_ID":23032,"compounds":"2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate","pmd":18.011}
{"X":3628,"KEGG":"R04209","RHEA_ID":10795,"DIRECTION":"BI","MASTER_ID":10792,"metacyc":"AIRCARBOXY-RXN","compounds":"5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2","pmd":43.99}
{"X":3629,"KEGG":"R04210","RHEA_ID":18832,"DIRECTION":"BI","MASTER_ID":18829,"compounds":"4-phospho-D-erythronate + NAD(+) <=> (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + H(+) + NADH","pmd":450.129}
{"X":3630,"KEGG":"R04210","RHEA_ID":18832,"DIRECTION":"BI","MASTER_ID":18829,"compounds":"4-phospho-D-erythronate + NAD(+) <=> (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + H(+) + NADH","pmd":2.016}
{"X":3631,"KEGG":"R04211","RHEA_ID":13468,"DIRECTION":"BI","MASTER_ID":13465,"compounds":"(S)-2,3-diaminopropanoate + oxalyl-CoA <=> CoA + N(3)-oxalyl-L-2,3-diaminopropanoate","pmd":71.985}
{"X":3632,"KEGG":"R04212","RHEA_ID":14516,"DIRECTION":"BI","MASTER_ID":14513,"compounds":"ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine <=> ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate","pmd":79.966}
{"X":3633,"KEGG":"R04212","RHEA_ID":14516,"DIRECTION":"BI","MASTER_ID":14513,"compounds":"ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine <=> ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate","pmd":0.984}
{"X":3634,"KEGG":"R04213","RHEA_ID":19980,"DIRECTION":"BI","MASTER_ID":19977,"compounds":"3'-phosphoadenylyl sulfate + L-tyrosine methyl ester <=> adenosine 3',5'-bisphosphate + H(+) + L-tyrosine methyl ester 4-sulfate","pmd":79.957}
{"X":3635,"KEGG":"R04216","RHEA_ID":22983,"DIRECTION":"BI","MASTER_ID":22980,"metacyc":"RXN-16761","compounds":"a dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] <=> dolichyl diphosphate + H(+) + N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein]"}
{"X":3636,"KEGG":"R04217","RHEA_ID":16956,"DIRECTION":"BI","MASTER_ID":16953,"compounds":"2-oxoglutarate + N(2)-succinyl-L-ornithine <=> L-glutamate + N-succinyl-L-glutamate 5-semialdehyde","pmd":1.032}
{"X":3637,"KEGG":"R04218","RHEA_ID":34482,"DIRECTION":"BI","MASTER_ID":34479,"compounds":"(1R,2R,3R)-prephytoene diphosphate <=> 15-cis-phytoene + diphosphate","pmd":177.943}
{"X":3638,"KEGG":"R04222","RHEA_ID":24395,"DIRECTION":"BI","MASTER_ID":24392,"compounds":"dTDP-L-dihydrostreptose + streptidine 6-phosphate <=> dTDP + H(+) + O-(1->4)-alpha-L-dihydrostreptosyl-streptidine 6-phosphate","pmd":59.918}
{"X":3639,"KEGG":"R04224","RHEA_ID":31178,"DIRECTION":"BI","MASTER_ID":31175,"metacyc":"METHYLACYLYLCOA-HYDROXY-RXN","compounds":"(2E)-2-methylpropenoyl-CoA + H2O <=> (S)-3-hydroxyisobutanoyl-CoA","pmd":18.011}
{"X":3640,"KEGG":"R04227","RHEA_ID":19288,"DIRECTION":"BI","MASTER_ID":19285,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + di-trans,poly-cis-dolichol <=> a 1-acyl-sn-glycero-3-phosphocholine + acyldolichol"}
{"X":3641,"KEGG":"R04228","RHEA_ID":22483,"DIRECTION":"BI","MASTER_ID":22480,"compounds":"4-(hydroxyamino)quinoline N-oxide + H2O + 2 NAD(+) <=> 4-nitroquinoline N-oxide + 2 H(+) + 2 NADH","pmd":13.979}
{"X":3642,"KEGG":"R04228","RHEA_ID":22483,"DIRECTION":"BI","MASTER_ID":22480,"compounds":"4-(hydroxyamino)quinoline N-oxide + H2O + 2 NAD(+) <=> 4-nitroquinoline N-oxide + 2 H(+) + 2 NADH","pmd":489.066}
{"X":3643,"KEGG":"R04229","RHEA_ID":22479,"DIRECTION":"BI","MASTER_ID":22476,"compounds":"4-(hydroxyamino)quinoline N-oxide + H2O + 2 NADP(+) <=> 4-nitroquinoline N-oxide + 2 H(+) + 2 NADPH","pmd":569.033}
{"X":3644,"KEGG":"R04229","RHEA_ID":22479,"DIRECTION":"BI","MASTER_ID":22476,"compounds":"4-(hydroxyamino)quinoline N-oxide + H2O + 2 NADP(+) <=> 4-nitroquinoline N-oxide + 2 H(+) + 2 NADPH","pmd":13.979}
{"X":3645,"KEGG":"R04230","RHEA_ID":25159,"DIRECTION":"BI","MASTER_ID":25156,"compounds":"(R)-4'-phosphopantothenate + ATP + L-cysteine <=> AMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine","pmd":47.986}
{"X":3646,"KEGG":"R04230","RHEA_ID":25159,"DIRECTION":"BI","MASTER_ID":25156,"compounds":"(R)-4'-phosphopantothenate + ATP + L-cysteine <=> AMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine","pmd":104.909}
{"X":3647,"KEGG":"R04230","RHEA_ID":25159,"DIRECTION":"BI","MASTER_ID":25156,"compounds":"(R)-4'-phosphopantothenate + ATP + L-cysteine <=> AMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine","pmd":226.043}
{"X":3648,"KEGG":"R04231","RHEA_ID":19400,"DIRECTION":"BI","MASTER_ID":19397,"compounds":"(R)-4'-phosphopantothenate + CTP + L-cysteine <=> CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine","pmd":23.975}
{"X":3649,"KEGG":"R04231","RHEA_ID":19400,"DIRECTION":"BI","MASTER_ID":19397,"compounds":"(R)-4'-phosphopantothenate + CTP + L-cysteine <=> CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine","pmd":202.032}
{"X":3650,"KEGG":"R04231","RHEA_ID":19400,"DIRECTION":"BI","MASTER_ID":19397,"compounds":"(R)-4'-phosphopantothenate + CTP + L-cysteine <=> CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine","pmd":80.898}
{"X":3651,"KEGG":"R04234","RHEA_ID":15592,"DIRECTION":"BI","MASTER_ID":15589,"metacyc":"2.6.1.72-RXN","compounds":"2-oxoglutarate + D-4-hydroxyphenylglycine <=> 4-hydroxyphenylglyoxylate + L-glutamate","pmd":1.032}
{"X":3652,"KEGG":"R04235","RHEA_ID":11399,"DIRECTION":"BI","MASTER_ID":11396,"compounds":"5-methyldeoxycytidine 5'-phosphate + ATP <=> 5-methyldeoxycytidine diphosphate + ADP","pmd":79.966}
{"X":3653,"KEGG":"R04236","RHEA_ID":21587,"DIRECTION":"BI","MASTER_ID":21584,"compounds":"NAD(+) + propane-1,2-diol 1-phosphate <=> H(+) + hydroxyacetone phosphate + NADH","pmd":510.114}
{"X":3654,"KEGG":"R04236","RHEA_ID":21587,"DIRECTION":"BI","MASTER_ID":21584,"compounds":"NAD(+) + propane-1,2-diol 1-phosphate <=> H(+) + hydroxyacetone phosphate + NADH","pmd":2.016}
{"X":3655,"KEGG":"R04237","RHEA_ID":17812,"DIRECTION":"BI","MASTER_ID":17809,"compounds":"Mg-protoporphyrin IX + S-adenosyl-L-methionine <=> Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":3656,"KEGG":"R04238","RHEA_ID":54451,"DIRECTION":"BI","MASTER_ID":54448,"compounds":"H2O + N-acyl-L-alpha-aminoacyl-tRNA <=> an N-acyl-L-amino acid + H(+) + tRNA"}
{"X":3657,"KEGG":"R04239","RHEA_ID":24547,"DIRECTION":"BI","MASTER_ID":24544,"compounds":"H2O + L-lysyl-[protein] + O2 <=> [protein]-(S)-2-amino-6-oxohexanoate + H2O2 + NH4(+)"}
{"X":3658,"KEGG":"R04241","RHEA_ID":10583,"DIRECTION":"BI","MASTER_ID":10580,"compounds":"(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n + ATP + L-glutamate <=> (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n+1 + ADP + H(+) + phosphate","pmd":279.976}
{"X":3659,"KEGG":"R04241","RHEA_ID":10583,"DIRECTION":"BI","MASTER_ID":10580,"compounds":"(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n + ATP + L-glutamate <=> (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n+1 + ADP + H(+) + phosphate","pmd":79.966}
{"X":3660,"KEGG":"R04242","RHEA_ID":56787,"DIRECTION":"BI","MASTER_ID":56784,"compounds":"(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n + (n-1) H2O <=> (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate"}
{"X":3661,"KEGG":"R04251","RHEA_ID":58155,"DIRECTION":"BI","MASTER_ID":58152,"compounds":"H2O + NAD(+) + phosphonoacetaldehyde <=> 2 H(+) + NADH + phosphonoacetate","pmd":15.995}
{"X":3662,"KEGG":"R04251","RHEA_ID":58155,"DIRECTION":"BI","MASTER_ID":58152,"compounds":"H2O + NAD(+) + phosphonoacetaldehyde <=> 2 H(+) + NADH + phosphonoacetate","pmd":524.129}
{"X":3663,"KEGG":"R04256","RHEA_ID":24123,"DIRECTION":"BI","MASTER_ID":24120,"compounds":"H(+) + leukotriene E4 + NADPH + O2 <=> 20-hydroxy-leukotriene E4 + H2O + NADP(+)","pmd":289.857}
{"X":3664,"KEGG":"R04256","RHEA_ID":24123,"DIRECTION":"BI","MASTER_ID":24120,"compounds":"H(+) + leukotriene E4 + NADPH + O2 <=> 20-hydroxy-leukotriene E4 + H2O + NADP(+)","pmd":15.995}
{"X":3665,"KEGG":"R04258","RHEA_ID":48579,"DIRECTION":"BI","MASTER_ID":48576,"compounds":"4-chlorocatechol + O2 <=> 3-chloro-cis,cis-muconate + 2 H(+)","pmd":31.99}
{"X":3666,"KEGG":"R04259","RHEA_ID":11035,"DIRECTION":"BI","MASTER_ID":11032,"metacyc":"RXN-9892","compounds":"(2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate <=> 3-chloro-cis,cis-muconate + H(+)","pmd":0}
{"X":3667,"KEGG":"R04260","RHEA_ID":31126,"DIRECTION":"BI","MASTER_ID":31123,"compounds":"muconolactone <=> (4,5-dihydro-5-oxofuran-2-yl)-acetate","pmd":0}
{"X":3668,"KEGG":"R04263","RHEA_ID":11899,"DIRECTION":"BI","MASTER_ID":11896,"compounds":"7alpha-hydroxycholesterol + NAD(+) <=> 7alpha-hydroxycholest-4-en-3-one + H(+) + NADH","pmd":2.016}
{"X":3669,"KEGG":"R04263","RHEA_ID":11899,"DIRECTION":"BI","MASTER_ID":11896,"compounds":"7alpha-hydroxycholesterol + NAD(+) <=> 7alpha-hydroxycholest-4-en-3-one + H(+) + NADH","pmd":263.783}
{"X":3670,"KEGG":"R04265","RHEA_ID":34570,"DIRECTION":"BI","MASTER_ID":34567,"compounds":"CDP-alpha-D-paratose + NADP(+) <=> CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH","pmd":2.016}
{"X":3671,"KEGG":"R04265","RHEA_ID":34570,"DIRECTION":"BI","MASTER_ID":34567,"compounds":"CDP-alpha-D-paratose + NADP(+) <=> CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH","pmd":213.018}
{"X":3672,"KEGG":"R04266","RHEA_ID":21659,"DIRECTION":"BI","MASTER_ID":21656,"compounds":"CDP-alpha-D-paratose <=> CDP-3,6-dideoxy-alpha-D-mannose","pmd":0}
{"X":3673,"KEGG":"R04267","RHEA_ID":11219,"DIRECTION":"BI","MASTER_ID":11216,"compounds":"a 2'-deoxyribonucleoside 5'-phosphate + ATP <=> a 2'-deoxyribonucleoside 5'-diphosphate + ADP","pmd":79.966}
{"X":3674,"KEGG":"R04270","RHEA_ID":10819,"DIRECTION":"BI","MASTER_ID":10816,"compounds":"H2O + methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside <=> L-fucose + methyl beta-D-galactoside","pmd":146.058}
{"X":3675,"KEGG":"R04271","RHEA_ID":20328,"DIRECTION":"BI","MASTER_ID":20325,"compounds":"N-hydroxy-4-acetylaminobiphenyl <=> N-acetoxy-4-aminobiphenyl","pmd":0}
{"X":3676,"KEGG":"R04272","RHEA_ID":15208,"DIRECTION":"BI","MASTER_ID":15205,"compounds":"a dolichyl diphosphooligosaccharide + H2O <=> an oligosaccharide-(1->4)-N-acetyl-beta-D-glucosamine-(1->4)-N-acetyl-alpha-D-glucosamine 1-phosphate + dolichyl phosphate + 2 H(+)"}
{"X":3677,"KEGG":"R04273","RHEA_ID":16240,"DIRECTION":"BI","MASTER_ID":16237,"ecocyc":"PEPTIDYLPROLYL-ISOMERASE-RXN","metacyc":"PEPTIDYLPROLYL-ISOMERASE-RXN","compounds":"[protein]-peptidylproline (omega=180) <=> [protein]-peptidylproline (omega=0)"}
{"X":3678,"KEGG":"R04274","RHEA_ID":23979,"DIRECTION":"BI","MASTER_ID":23976,"compounds":"(RNA)-3'-(3'-phospho-ribonucleoside) + ATP <=> (RNA)-3'-(2',3'-cyclophospho)-ribonucleoside + AMP + diphosphate","pmd":159.933}
{"X":3679,"KEGG":"R04275","RHEA_ID":17136,"DIRECTION":"BI","MASTER_ID":17133,"compounds":"ATP + L-seryl-[tyrosine-3-monooxygenase] <=> ADP + H(+) + O-phospho-L-seryl-[tyrosine-3-monooxygenase]","pmd":79.966}
{"X":3680,"KEGG":"R04277","RHEA_ID":10647,"DIRECTION":"BI","MASTER_ID":10644,"metacyc":"RXN-2462","compounds":"2-oxo-2H-pyran-4,6-dicarboxylate + H2O <=> (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H(+)","pmd":18.011}
{"X":3681,"KEGG":"R04279","RHEA_ID":29590,"DIRECTION":"BI","MASTER_ID":29587,"compounds":"4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+) <=> 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + NADPH","pmd":2.016}
{"X":3682,"KEGG":"R04279","RHEA_ID":29590,"DIRECTION":"BI","MASTER_ID":29587,"compounds":"4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+) <=> 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + NADPH","pmd":560.082}
{"X":3683,"KEGG":"R04280","RHEA_ID":31130,"DIRECTION":"BI","MASTER_ID":31127,"compounds":"3-O-methylgallate + O2 <=> 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + methanol","pmd":0.036}
{"X":3684,"KEGG":"R04285","RHEA_ID":11775,"DIRECTION":"BI","MASTER_ID":11772,"compounds":"6-lactoyl-5,6,7,8-tetrahydropterin + NADP(+) <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH","pmd":506.997}
{"X":3685,"KEGG":"R04285","RHEA_ID":11775,"DIRECTION":"BI","MASTER_ID":11772,"compounds":"6-lactoyl-5,6,7,8-tetrahydropterin + NADP(+) <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH","pmd":2.016}
{"X":3686,"KEGG":"R04286","RHEA_ID":22051,"DIRECTION":"BI","MASTER_ID":22048,"compounds":"7,8-dihydroneopterin 3'-triphosphate <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate","pmd":257.909}
{"X":3687,"KEGG":"R04291","RHEA_ID":13584,"DIRECTION":"BI","MASTER_ID":13581,"compounds":"N(4)-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UMP","pmd":283.046}
{"X":3688,"KEGG":"R04292","RHEA_ID":25891,"DIRECTION":"BI","MASTER_ID":25888,"compounds":"dihydroxyacetone phosphate + iminosuccinate <=> H(+) + 2 H2O + phosphate + quinolinate","pmd":2.976}
{"X":3689,"KEGG":"R04293","RHEA_ID":25150,"DIRECTION":"BI","MASTER_ID":25147,"compounds":"(2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde <=> H(+) + H2O + quinolinate","pmd":18.011}
{"X":3690,"KEGG":"R04294","RHEA_ID":23255,"DIRECTION":"BI","MASTER_ID":23252,"compounds":"[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O <=> [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate"}
{"X":3691,"KEGG":"R04296","RHEA_ID":12856,"DIRECTION":"BI","MASTER_ID":12853,"metacyc":"RXN-743","compounds":"(S)-4-hydroxymandelonitrile + UDP-alpha-D-glucose <=> dhurrin + H(+) + UDP","pmd":162.053}
{"X":3692,"KEGG":"R04297","RHEA_ID":21003,"DIRECTION":"BI","MASTER_ID":21000,"compounds":"1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene <=> 1,2,3,5-tetrahydroxybenzene + 1,3,5-trihydroxybenzene","pmd":0}
{"X":3693,"KEGG":"R04300","RHEA_ID":27949,"DIRECTION":"BI","MASTER_ID":27946,"compounds":"dopamine + H2O + O2 <=> 3,4-dihydroxyphenylacetaldehyde + H2O2 + NH4(+)","pmd":1.032}
{"X":3694,"KEGG":"R04303","RHEA_ID":19792,"DIRECTION":"BI","MASTER_ID":19789,"compounds":"4-(dimethylamino)azobenzene + H2O + NADP(+) <=> 4-(dimethylamino)phenylazoxybenzene + H(+) + NADPH","pmd":15.995}
{"X":3695,"KEGG":"R04303","RHEA_ID":19792,"DIRECTION":"BI","MASTER_ID":19789,"compounds":"4-(dimethylamino)azobenzene + H2O + NADP(+) <=> 4-(dimethylamino)phenylazoxybenzene + H(+) + NADPH","pmd":502.962}
{"X":3696,"KEGG":"R04305","RHEA_ID":16176,"DIRECTION":"BI","MASTER_ID":16173,"compounds":"(4-hydroxyphenyl)acetaldehyde + dopamine <=> (S)-norcoclaurine + H2O","pmd":135.068}
{"X":3697,"KEGG":"R04305","RHEA_ID":16176,"DIRECTION":"BI","MASTER_ID":16173,"compounds":"(4-hydroxyphenyl)acetaldehyde + dopamine <=> (S)-norcoclaurine + H2O","pmd":118.042}
{"X":3698,"KEGG":"R04306","RHEA_ID":50731,"DIRECTION":"BI","MASTER_ID":50728,"compounds":"(Z)-(4-hydroxyphenyl)acetaldehyde oxime <=> 4-hydroxyphenylacetonitrile + H2O","pmd":18.011}
{"X":3699,"KEGG":"R04307","RHEA_ID":17432,"DIRECTION":"BI","MASTER_ID":17429,"compounds":"NAD(+) + trans-4-hydroxycyclohexanecarboxylate <=> 4-oxocyclohexanecarboxylate + H(+) + NADH","pmd":522.054}
{"X":3700,"KEGG":"R04307","RHEA_ID":17432,"DIRECTION":"BI","MASTER_ID":17429,"compounds":"NAD(+) + trans-4-hydroxycyclohexanecarboxylate <=> 4-oxocyclohexanecarboxylate + H(+) + NADH","pmd":2.016}
{"X":3701,"KEGG":"R04309","RHEA_ID":10359,"DIRECTION":"BI","MASTER_ID":10356,"compounds":"3alpha-hydroxy-5beta-androstan-17-one + NAD(+) <=> 5beta-androstane-3,17-dione + H(+) + NADH","pmd":375.908}
{"X":3702,"KEGG":"R04309","RHEA_ID":10359,"DIRECTION":"BI","MASTER_ID":10356,"compounds":"3alpha-hydroxy-5beta-androstan-17-one + NAD(+) <=> 5beta-androstane-3,17-dione + H(+) + NADH","pmd":2.016}
{"X":3703,"KEGG":"R04311","RHEA_ID":36174,"DIRECTION":"BI","MASTER_ID":36171,"metacyc":"ALKYLGLYCERONE-PHOSPHATE-SYNTHASE-RXN","compounds":"a 1-acylglycerone 3-phosphate + a long chain fatty alcohol <=> 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+)"}
{"X":3704,"KEGG":"R04314","RHEA_ID":24003,"DIRECTION":"BI","MASTER_ID":24000,"compounds":"a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] <=> a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]"}
{"X":3705,"KEGG":"R04315","RHEA_ID":12704,"DIRECTION":"BI","MASTER_ID":12701,"metacyc":"1.17.4.2-RXN","compounds":"[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-triphosphate + H2O <=> [thioredoxin]-dithiol + a ribonucleoside 5'-triphosphate"}
{"X":3706,"KEGG":"R04316","RHEA_ID":16436,"DIRECTION":"BI","MASTER_ID":16433,"compounds":"acetyl-CoA + N-terminal L-alanyl-[ribosomal protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein]","pmd":42.011}
{"X":3707,"KEGG":"R04317","RHEA_ID":16084,"DIRECTION":"BI","MASTER_ID":16081,"compounds":"(2R)-S-methyl-3-phospho-1-thioglycerate + H2O <=> (2R)-S-methyl-1-thioglycerate + phosphate","pmd":79.966}
{"X":3708,"KEGG":"R04319","RHEA_ID":12139,"DIRECTION":"BI","MASTER_ID":12136,"compounds":"a 4,5-saturated-(2E)-enoyl-CoA + NADP(+) <=> a (2E,4E)-dienoyl-CoA + H(+) + NADPH"}
{"X":3709,"KEGG":"R04320","RHEA_ID":14120,"DIRECTION":"BI","MASTER_ID":14117,"compounds":"[(1->4)-alpha-D-galacturonosyl](n) + H2O <=> [(1->4)-alpha-D-galacturonosyl](n-1) + alpha-D-galacturonate"}
{"X":3710,"KEGG":"R04321","RHEA_ID":36186,"DIRECTION":"BI","MASTER_ID":36183,"compounds":"a 1-O-alkyl-2-acetyl-sn-glycerol + CDP-choline <=> 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+)","pmd":165.055}
{"X":3711,"KEGG":"R04322","RHEA_ID":10859,"DIRECTION":"BI","MASTER_ID":10856,"compounds":"a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose <=> a 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + H(+) + UDP","pmd":162.053}
{"X":3712,"KEGG":"R04323","RHEA_ID":16560,"DIRECTION":"BI","MASTER_ID":16557,"compounds":"2-amino-3-carboxymuconate 6-semialdehyde + H(+) <=> 2-aminomuconate 6-semialdehyde + CO2","pmd":43.99}
{"X":3713,"KEGG":"R04325","RHEA_ID":15056,"DIRECTION":"BI","MASTER_ID":15053,"ecocyc":"GART-RXN","metacyc":"GART-RXN","compounds":"(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-D-ribosyl)glycinamide <=> (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide","pmd":27.995}
{"X":3714,"KEGG":"R04326","RHEA_ID":31134,"DIRECTION":"BI","MASTER_ID":31131,"compounds":"5,10-methenyltetrahydrofolate + H2O + N(1)-(5-phospho-D-ribosyl)glycinamide <=> (6S)-5,6,7,8-tetrahydrofolate + 2 H(+) + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide","pmd":10.992}
{"X":3715,"KEGG":"R04326","RHEA_ID":31134,"DIRECTION":"BI","MASTER_ID":31131,"compounds":"5,10-methenyltetrahydrofolate + H2O + N(1)-(5-phospho-D-ribosyl)glycinamide <=> (6S)-5,6,7,8-tetrahydrofolate + 2 H(+) + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide","pmd":27.995}
{"X":3716,"KEGG":"R04327","RHEA_ID":18748,"DIRECTION":"BI","MASTER_ID":18745,"compounds":"2 juglone + O2 <=> 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+)","pmd":15.995}
{"X":3717,"KEGG":"R04330","RHEA_ID":42007,"DIRECTION":"BI","MASTER_ID":42004,"compounds":"5alpha-androstane-3alpha,17beta-diol + NAD(+) <=> 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH","pmd":2.016}
{"X":3718,"KEGG":"R04330","RHEA_ID":42007,"DIRECTION":"BI","MASTER_ID":42004,"compounds":"5alpha-androstane-3alpha,17beta-diol + NAD(+) <=> 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH","pmd":373.892}
{"X":3719,"KEGG":"R04332","RHEA_ID":20416,"DIRECTION":"BI","MASTER_ID":20413,"compounds":"glucuronoxylan D-glucuronate + n S-adenosyl-L-methionine <=> glucuronoxylan 4-O-methyl-D-glucuronate + n H(+) + n S-adenosyl-L-homocysteine","pmd":14.016}
{"X":3720,"KEGG":"R04333","RHEA_ID":21183,"DIRECTION":"BI","MASTER_ID":21180,"compounds":"1-O-(indol-3-ylacetyl)-beta-D-glucose + myo-inositol <=> D-glucose + indole-3-acetyl-1D-myo-inositol","pmd":0}
{"X":3721,"KEGG":"R04334","RHEA_ID":21151,"DIRECTION":"BI","MASTER_ID":21148,"compounds":"indole-3-acetyl-1D-myo-inositol + UDP-alpha-D-galactose <=> 5-O-(indol-3-ylacetyl)-myo-inositol D-galactoside + H(+) + UDP","pmd":66.886}
{"X":3722,"KEGG":"R04335","RHEA_ID":19508,"DIRECTION":"BI","MASTER_ID":19505,"compounds":"indole-3-acetyl-1D-myo-inositol + UDP-beta-L-arabinopyranose <=> (indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + H(+) + UDP","pmd":66.886}
{"X":3723,"KEGG":"R04336","RHEA_ID":24800,"DIRECTION":"BI","MASTER_ID":24797,"compounds":"(S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O <=> (S)-2-amino-6-oxoheptanedioate","pmd":18.011}
{"X":3724,"KEGG":"R04338","RHEA_ID":13488,"DIRECTION":"BI","MASTER_ID":13485,"metacyc":"CYSTEINE-CONJUGATE-TRANSAMINASE-RXN","compounds":"2-oxoglutarate + S-(4-bromophenyl)-L-cysteine <=> (4-bromophenylsulfanyl)pyruvate + L-glutamate","pmd":1.032}
{"X":3725,"KEGG":"R04339","RHEA_ID":12507,"DIRECTION":"BI","MASTER_ID":12504,"compounds":"NAD(+) + thiomorpholine-3-carboxylate <=> 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADH","pmd":519.097}
{"X":3726,"KEGG":"R04339","RHEA_ID":12507,"DIRECTION":"BI","MASTER_ID":12504,"compounds":"NAD(+) + thiomorpholine-3-carboxylate <=> 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADH","pmd":2.016}
{"X":3727,"KEGG":"R04340","RHEA_ID":12503,"DIRECTION":"BI","MASTER_ID":12500,"compounds":"NADP(+) + thiomorpholine-3-carboxylate <=> 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADPH","pmd":599.064}
{"X":3728,"KEGG":"R04340","RHEA_ID":12503,"DIRECTION":"BI","MASTER_ID":12500,"compounds":"NADP(+) + thiomorpholine-3-carboxylate <=> 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADPH","pmd":2.016}
{"X":3729,"KEGG":"R04341","RHEA_ID":10035,"DIRECTION":"BI","MASTER_ID":10032,"compounds":"[protein]-C-terminal-L-glutamine + H2O <=> [protein]-C-terminal-L-glutamate + NH4(+)"}
{"X":3730,"KEGG":"R04342","RHEA_ID":16268,"DIRECTION":"BI","MASTER_ID":16265,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + trans-5-O-(4-coumaroyl)-D-quinate <=> 5-O-[(E)-caffeoyl]-D-quinate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":3731,"KEGG":"R04343","RHEA_ID":13576,"DIRECTION":"BI","MASTER_ID":13573,"compounds":"[(1->4)-alpha-D-galacturonosyl](n) + UDP-alpha-D-galacturonate <=> [(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP","pmd":176.032}
{"X":3732,"KEGG":"R04344","RHEA_ID":16300,"DIRECTION":"BI","MASTER_ID":16297,"metacyc":"1.1.1.210-RXN","compounds":"5alpha-androstane-3beta,17beta-diol + NADP(+) <=> 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH","pmd":2.016}
{"X":3733,"KEGG":"R04344","RHEA_ID":16300,"DIRECTION":"BI","MASTER_ID":16297,"metacyc":"1.1.1.210-RXN","compounds":"5alpha-androstane-3beta,17beta-diol + NADP(+) <=> 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH","pmd":453.859}
{"X":3734,"KEGG":"R04345","RHEA_ID":17440,"DIRECTION":"BI","MASTER_ID":17437,"compounds":"2,4-dichloro-5-oxo-2,5-dihydro-2-furylacetate <=> (2E,4E)-2,4-dichloromuconate + H(+)","pmd":0}
{"X":3735,"KEGG":"R04346","RHEA_ID":10235,"DIRECTION":"BI","MASTER_ID":10232,"compounds":"5,6-dihydrouridine 5'-monophosphate + diphosphate <=> 5,6-dihydrouracil + 5-phospho-alpha-D-ribose 1-diphosphate","pmd":63.9}
{"X":3736,"KEGG":"R04348","RHEA_ID":12668,"DIRECTION":"BI","MASTER_ID":12665,"metacyc":"AMINOGLYCOSIDE-N3-ACETYLTRANSFERASE-RXN","compounds":"a 2-deoxystreptamine antibiotic + acetyl-CoA <=> an N(3')-acetyl-2-deoxystreptamine antibiotic + CoA + H(+)","pmd":42.011}
{"X":3737,"KEGG":"R04349","RHEA_ID":22103,"DIRECTION":"BI","MASTER_ID":22100,"compounds":"3,5-dibromo-4-hydroxybenzonitrile + 2 H2O <=> 3,5-dibromo-4-hydroxybenzoate + NH4(+)","pmd":18.995}
{"X":3738,"KEGG":"R04350","RHEA_ID":13376,"DIRECTION":"BI","MASTER_ID":13373,"compounds":"H2O + L-mimosine <=> 3-hydroxy-4H-pyrid-4-one + L-serine","pmd":87.032}
{"X":3739,"KEGG":"R04356","RHEA_ID":20088,"DIRECTION":"BI","MASTER_ID":20085,"compounds":"a flavonol 3-O-beta-D-glucoside + malonyl-CoA <=> a flavonol 3-O-(6-O-malonyl-beta-D-glucoside) + CoA","pmd":86}
{"X":3740,"KEGG":"R04357","RHEA_ID":11763,"DIRECTION":"BI","MASTER_ID":11760,"compounds":"4 ATP + citrate + 2 H2O + 2 N(6)-acetyl-N(6)-hydroxy-L-lysine <=> 4 ADP + aerobactin + 4 H(+) + 4 phosphate"}
{"X":3741,"KEGG":"R04358","RHEA_ID":10219,"DIRECTION":"BI","MASTER_ID":10216,"metacyc":"RNA-POLYMERASE-SUBUNIT-KINASE-RXN","compounds":"[DNA-directed RNA polymerase] + ATP <=> ADP + H(+) + phospho-[DNA-directed RNA polymerase]","pmd":79.966}
{"X":3742,"KEGG":"R04359","RHEA_ID":14464,"DIRECTION":"BI","MASTER_ID":14461,"compounds":"(25S)-5beta-spirostan-3beta-ol + UDP-alpha-D-glucose <=> (25S)-5beta-spirostan-3beta-yl beta-D-glucoside + H(+) + UDP","pmd":12.327}
{"X":3743,"KEGG":"R04360","RHEA_ID":36178,"DIRECTION":"BI","MASTER_ID":36175,"compounds":"1-O-alkylglycerone 3-phosphate + H(+) + NADPH <=> 1-O-alkyl-sn-glycero-3-phosphate + NADP(+)"}
{"X":3744,"KEGG":"R04361","RHEA_ID":36238,"DIRECTION":"BI","MASTER_ID":36235,"compounds":"1-O-alkyl-sn-glycero-3-phosphate + an acyl-CoA <=> 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + CoA"}
{"X":3745,"KEGG":"R04362","RHEA_ID":15968,"DIRECTION":"BI","MASTER_ID":15965,"compounds":"1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)"}
{"X":3746,"KEGG":"R04363","RHEA_ID":21999,"DIRECTION":"BI","MASTER_ID":21996,"compounds":"a 1-O-alkyl-2-acetyl-sn-glycerol + an acyl-CoA <=> a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + CoA"}
{"X":3747,"KEGG":"R04364","RHEA_ID":13088,"DIRECTION":"BI","MASTER_ID":13085,"compounds":"(S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O <=> CoA + L-2-acetamido-6-oxoheptanedioate","pmd":42.011}
{"X":3748,"KEGG":"R04364","RHEA_ID":13088,"DIRECTION":"BI","MASTER_ID":13085,"compounds":"(S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O <=> CoA + L-2-acetamido-6-oxoheptanedioate","pmd":60.021}
{"X":3749,"KEGG":"R04365","RHEA_ID":17328,"DIRECTION":"BI","MASTER_ID":17325,"ecocyc":"TETHYDPICSUCC-RXN","metacyc":"TETHYDPICSUCC-RXN","compounds":"(S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA <=> (S)-2-succinylamino-6-oxoheptanedioate + CoA","pmd":118.027}
{"X":3750,"KEGG":"R04365","RHEA_ID":17328,"DIRECTION":"BI","MASTER_ID":17325,"ecocyc":"TETHYDPICSUCC-RXN","metacyc":"TETHYDPICSUCC-RXN","compounds":"(S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA <=> (S)-2-succinylamino-6-oxoheptanedioate + CoA","pmd":100.016}
{"X":3751,"KEGG":"R04366","RHEA_ID":32506,"DIRECTION":"BI","MASTER_ID":32503,"compounds":"linalool + O2 + reduced [NADPH--hemoprotein reductase] <=> (6E)-8-hydroxylinalool + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":3752,"KEGG":"R04366","RHEA_ID":20763,"DIRECTION":"BI","MASTER_ID":20760,"metacyc":"LINALOOL-8-MONOOXYGENASE-RXN","compounds":"AH2 + linalool + O2 <=> (6E)-8-hydroxylinalool + A + H2O","pmd":15.995}
{"X":3753,"KEGG":"R04367","RHEA_ID":22771,"DIRECTION":"BI","MASTER_ID":22768,"compounds":"4-nitrophenyl-3-ketovalidamine <=> 4-nitroaniline + 5D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one","pmd":138.043}
{"X":3754,"KEGG":"R04368","RHEA_ID":37102,"DIRECTION":"BI","MASTER_ID":37099,"metacyc":"RXN-12826","compounds":"a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + H2O <=> 7-methyl-GMP + a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+)"}
{"X":3755,"KEGG":"R04370","RHEA_ID":16408,"DIRECTION":"BI","MASTER_ID":16405,"compounds":"benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP(+) <=> benzyl 2-methyl-3-oxobutanoate + H(+) + NADPH","pmd":2.016}
{"X":3756,"KEGG":"R04370","RHEA_ID":16408,"DIRECTION":"BI","MASTER_ID":16405,"compounds":"benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP(+) <=> benzyl 2-methyl-3-oxobutanoate + H(+) + NADPH","pmd":537.989}
{"X":3757,"KEGG":"R04371","RHEA_ID":15488,"DIRECTION":"BI","MASTER_ID":15485,"metacyc":"HOMOACONITATE-HYDRATASE-RXN","compounds":"(1R,2S)-homoisocitrate <=> cis-homoaconitate + H2O","pmd":18.011}
{"X":3758,"KEGG":"R04373","RHEA_ID":24375,"DIRECTION":"BI","MASTER_ID":24372,"compounds":"H2O + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] <=> H(+) + N(4)-[6-phospho-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + N-acetyl-D-glucosamine"}
{"X":3759,"KEGG":"R04374","RHEA_ID":10323,"DIRECTION":"BI","MASTER_ID":10320,"compounds":"trans-3-hydroxy-L-proline <=> 1-pyrroline-2-carboxylate + H2O","pmd":18.01}
{"X":3760,"KEGG":"R04376","RHEA_ID":23843,"DIRECTION":"BI","MASTER_ID":23840,"compounds":"3-(2,3-dihydroxyphenyl)propanoate + O2 <=> (2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H(+)","pmd":31.99}
{"X":3761,"KEGG":"R04377","RHEA_ID":39034,"DIRECTION":"BI","MASTER_ID":39031,"metacyc":"RXN-15117","compounds":"a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose <=> a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP","pmd":162.053}
{"X":3762,"KEGG":"R04378","RHEA_ID":31138,"DIRECTION":"BI","MASTER_ID":31135,"compounds":"5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + diphosphate <=> 5-amino-4-imidazolecarboxyamide + 5-phospho-alpha-D-ribose 1-diphosphate","pmd":51.889}
{"X":3763,"KEGG":"R04379","RHEA_ID":18816,"DIRECTION":"BI","MASTER_ID":18813,"compounds":"(2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate <=> (3E,5R)-5-carboxy-2-oxohept-3-enedioate","pmd":0}
{"X":3764,"KEGG":"R04382","RHEA_ID":20272,"DIRECTION":"BI","MASTER_ID":20269,"metacyc":"OLIGOGALACTURONIDE-LYASE-RXN","compounds":"4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate <=> 2 5-dehydro-4-deoxy-D-glucuronate","pmd":176.032}
{"X":3765,"KEGG":"R04383","RHEA_ID":23899,"DIRECTION":"BI","MASTER_ID":23896,"ecocyc":"5.3.1.17-RXN","metacyc":"5.3.1.17-RXN","compounds":"5-dehydro-4-deoxy-D-glucuronate <=> 3-deoxy-D-glycero-2,5-hexodiulosonate","pmd":0}
{"X":3766,"KEGG":"R04384","RHEA_ID":21347,"DIRECTION":"BI","MASTER_ID":21344,"metacyc":"2.1.1.90-RXN","compounds":"5-hydroxybenzimidazolylcob(I)amide + H(+) + methanol <=> Co-methyl-Co-5-hydroxybenzimidazolylcob(III)amide + H2O"}
{"X":3767,"KEGG":"R04384","RHEA_ID":45207,"DIRECTION":"BI","MASTER_ID":45204,"compounds":"[Co(I) methanol-specific corrinoid protein] + H(+) + methanol <=> [methyl-Co(III) methanol-specific corrinoid protein] + H2O"}
{"X":3768,"KEGG":"R04385","RHEA_ID":13504,"DIRECTION":"BI","MASTER_ID":13501,"compounds":"ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] <=> ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate","pmd":79.966}
{"X":3769,"KEGG":"R04386","RHEA_ID":54731,"DIRECTION":"BI","MASTER_ID":54728,"compounds":"acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] <=> malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]","pmd":43.99}
{"X":3770,"KEGG":"R04387","RHEA_ID":21011,"DIRECTION":"BI","MASTER_ID":21008,"compounds":"diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP(+) <=> diethyl 2-methyl-3-oxosuccinate + H(+) + NADPH","pmd":541.999}
{"X":3771,"KEGG":"R04387","RHEA_ID":21011,"DIRECTION":"BI","MASTER_ID":21008,"compounds":"diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP(+) <=> diethyl 2-methyl-3-oxosuccinate + H(+) + NADPH","pmd":2.016}
{"X":3772,"KEGG":"R04388","RHEA_ID":17556,"DIRECTION":"BI","MASTER_ID":17553,"compounds":"ATP + guanidinoethyl methyl phosphate <=> ADP + H(+) + N'-phosphoguanidinoethyl methylphosphate","pmd":79.966}
{"X":3773,"KEGG":"R04389","RHEA_ID":20200,"DIRECTION":"BI","MASTER_ID":20197,"metacyc":"5.1.3.17-RXN","compounds":"[heparosan-N-sulfate](n) <=> [heparan-N-sulfate](n)"}
{"X":3774,"KEGG":"R04392","RHEA_ID":19560,"DIRECTION":"BI","MASTER_ID":19557,"compounds":"AH2 + O2 + pregna-4,9(11)-diene-3,20-dione <=> 9,11alpha-epoxypregn-4-ene-3,20-dione + A + H2O","pmd":15.995}
{"X":3775,"KEGG":"R04393","RHEA_ID":42403,"DIRECTION":"BI","MASTER_ID":42400,"compounds":"lactose(out) + N(pros)-phospho-L-histidyl-[protein] <=> L-histidyl-[protein] + lactose 6-phosphate(in)","pmd":79.966}
{"X":3776,"KEGG":"R04397","RHEA_ID":17680,"DIRECTION":"BI","MASTER_ID":17677,"compounds":"2-(acetamidomethylene)-3-(hydroxymethyl)succinate + H(+) + 2 H2O <=> 2-(hydroxymethyl)-4-oxobutanoate + acetate + CO2 + NH4(+)","pmd":85.016}
{"X":3777,"KEGG":"R04398","RHEA_ID":16596,"DIRECTION":"BI","MASTER_ID":16593,"compounds":"3,3',4',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine <=> 3,3',4',5,7-pentahydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":3778,"KEGG":"R04400","RHEA_ID":21459,"DIRECTION":"BI","MASTER_ID":21456,"compounds":"(S)-tetrahydrocolumbamine + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-canadine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]","pmd":2.016}
{"X":3779,"KEGG":"R04401","RHEA_ID":43543,"DIRECTION":"BI","MASTER_ID":43540,"ecocyc":"PHOSICITDEHASE-RXN","metacyc":"PHOSICITDEHASE-RXN","compounds":"[isocitrate dehydrogenase]-L-serine + ATP <=> [isocitrate dehydrogenase]-O-phospho-L-serine + ADP + H(+)","pmd":79.966}
{"X":3780,"KEGG":"R04403","RHEA_ID":20332,"DIRECTION":"BI","MASTER_ID":20329,"compounds":"ATP + L-seryl-[low-density-lipoprotein receptor] <=> ADP + H(+) + O-phospho-L-seryl-[low-density-lipoprotein receptor]","pmd":79.966}
{"X":3781,"KEGG":"R04404","RHEA_ID":22767,"DIRECTION":"BI","MASTER_ID":22764,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O <=> 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate"}
{"X":3782,"KEGG":"R04405","RHEA_ID":21199,"DIRECTION":"BI","MASTER_ID":21196,"ecocyc":"HOMOCYSMET-RXN","metacyc":"HOMOCYSMET-RXN","compounds":"5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine <=> L-methionine + tetrahydropteroyltri-L-glutamate","pmd":14.016}
{"X":3783,"KEGG":"R04411","RHEA_ID":23527,"DIRECTION":"BI","MASTER_ID":23524,"compounds":"1-O-(trans-cinnamoyl)-beta-D-glucose + an alcohol <=> an alkyl cinnamate + beta-D-glucose","pmd":130.042}
{"X":3784,"KEGG":"R04412","RHEA_ID":22807,"DIRECTION":"BI","MASTER_ID":22804,"compounds":"(6S,9R)-vomifoliol + NAD(+) <=> (6S)-6-hydroxy-3-oxo-alpha-ionone + H(+) + NADH","pmd":2.016}
{"X":3785,"KEGG":"R04412","RHEA_ID":22807,"DIRECTION":"BI","MASTER_ID":22804,"compounds":"(6S,9R)-vomifoliol + NAD(+) <=> (6S)-6-hydroxy-3-oxo-alpha-ionone + H(+) + NADH","pmd":441.991}
{"X":3786,"KEGG":"R04413","RHEA_ID":16248,"DIRECTION":"BI","MASTER_ID":16245,"metacyc":"2.3.1.121-RXN","compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":3787,"KEGG":"R04418","RHEA_ID":15684,"DIRECTION":"BI","MASTER_ID":15681,"compounds":"2-hydroxy-5-carboxymethylmuconate semialdehyde + H2O + NAD(+) <=> (2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate + 2 H(+) + NADH","pmd":15.995}
{"X":3788,"KEGG":"R04418","RHEA_ID":15684,"DIRECTION":"BI","MASTER_ID":15681,"compounds":"2-hydroxy-5-carboxymethylmuconate semialdehyde + H2O + NAD(+) <=> (2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate + 2 H(+) + NADH","pmd":448.09}
{"X":3789,"KEGG":"R04420","RHEA_ID":19992,"DIRECTION":"BI","MASTER_ID":19989,"compounds":"S-methyl-5-thio-alpha-D-ribose 1-phosphate <=> 5-methylsulfanyl-D-ribulose 1-phosphate","pmd":0}
{"X":3790,"KEGG":"R04421","RHEA_ID":17408,"DIRECTION":"BI","MASTER_ID":17405,"compounds":"N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine <=> H(+) + N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":3791,"KEGG":"R04423","RHEA_ID":19024,"DIRECTION":"BI","MASTER_ID":19021,"compounds":"an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-N-acetyl-alpha-D-galactosamine <=> an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP","pmd":203.079}
{"X":3792,"KEGG":"R04424","RHEA_ID":17728,"DIRECTION":"BI","MASTER_ID":17725,"metacyc":"2-METHYLCITRATE-DEHYDRATASE-RXN","compounds":"(2S,3S)-2-methylcitrate <=> 2-methyl-cis-aconitate + H2O","pmd":18.011}
{"X":3793,"KEGG":"R04425","RHEA_ID":17944,"DIRECTION":"BI","MASTER_ID":17941,"ecocyc":"4.2.1.99-RXN","metacyc":"4.2.1.99-RXN","compounds":"(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate <=> 2-methyl-cis-aconitate + H2O","pmd":18.011}
{"X":3794,"KEGG":"R04426","RHEA_ID":10895,"DIRECTION":"BI","MASTER_ID":10892,"ecocyc":"3-ISOPROPYLMALDEHYDROG-RXN","metacyc":"3-ISOPROPYLMALDEHYDROG-RXN","compounds":"(2R,3S)-3-isopropylmalate + NAD(+) <=> (2S)-2-isopropyl-3-oxosuccinate + H(+) + NADH","pmd":2.016}
{"X":3795,"KEGG":"R04426","RHEA_ID":10895,"DIRECTION":"BI","MASTER_ID":10892,"ecocyc":"3-ISOPROPYLMALDEHYDROG-RXN","metacyc":"3-ISOPROPYLMALDEHYDROG-RXN","compounds":"(2R,3S)-3-isopropylmalate + NAD(+) <=> (2S)-2-isopropyl-3-oxosuccinate + H(+) + NADH","pmd":490.064}
{"X":3796,"KEGG":"R04427","RHEA_ID":21131,"DIRECTION":"BI","MASTER_ID":21128,"compounds":"5alpha-cholesta-8,24-dien-3beta-ol + S-adenosyl-L-methionine <=> 24-methylene-5alpha-cholest-8-en-3beta-ol + H(+) + S-adenosyl-L-homocysteine","pmd":0.218}
{"X":3797,"KEGG":"R04431","RHEA_ID":18416,"DIRECTION":"BI","MASTER_ID":18413,"compounds":"a beta-D-galactosyl-(1->4)-beta-D-glucosyl derivative + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosaminyl derivative + H(+) + UDP","pmd":162.053}
{"X":3798,"KEGG":"R04432","RHEA_ID":31290,"DIRECTION":"BI","MASTER_ID":31287,"compounds":"H(+) + oxidized [electron-transfer flavoprotein] + propanoyl-CoA <=> acryloyl-CoA + reduced [electron-transfer flavoprotein]","pmd":2.016}
{"X":3799,"KEGG":"R04433","RHEA_ID":24055,"DIRECTION":"BI","MASTER_ID":24052,"metacyc":"1.5.5.1-RXN","compounds":"a ubiquinone + reduced [electron-transfer flavoprotein] <=> a ubiquinol + H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":3800,"KEGG":"R04436","RHEA_ID":11107,"DIRECTION":"BI","MASTER_ID":11104,"compounds":"N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-methionine <=> H(+) + hercynine + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":3801,"KEGG":"R04436","RHEA_ID":11107,"DIRECTION":"BI","MASTER_ID":11104,"compounds":"N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-methionine <=> H(+) + hercynine + S-adenosyl-L-homocysteine","pmd":15.024}
{"X":3802,"KEGG":"R04437","RHEA_ID":14104,"DIRECTION":"BI","MASTER_ID":14101,"compounds":"[eIF5A protein]-deoxyhypusine + AH2 + O2 <=> [eIF5A protein]-hypusine + A + H2O"}
{"X":3803,"KEGG":"R04438","RHEA_ID":10371,"DIRECTION":"BI","MASTER_ID":10368,"metacyc":"2.6.1.59-RXN","compounds":"2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-galactose <=> dTDP-4-dehydro-6-deoxy-D-galactose + L-glutamate","pmd":1.032}
{"X":3804,"KEGG":"R04439","RHEA_ID":22071,"DIRECTION":"BI","MASTER_ID":22068,"ecocyc":"ACETOLACTREDUCTOISOM-RXN","metacyc":"RXN-16061","compounds":"(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) <=> (2S)-2-acetolactate + H(+) + NADPH","pmd":612.041}
{"X":3805,"KEGG":"R04439","RHEA_ID":22071,"DIRECTION":"BI","MASTER_ID":22068,"ecocyc":"ACETOLACTREDUCTOISOM-RXN","metacyc":"RXN-16061","compounds":"(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) <=> (2S)-2-acetolactate + H(+) + NADPH","pmd":2.016}
{"X":3806,"KEGG":"R04439","RHEA_ID":22071,"DIRECTION":"BI","MASTER_ID":22068,"ecocyc":"ACETOLACTREDUCTOISOM-RXN","metacyc":"ACETOLACTREDUCTOISOM-RXN","compounds":"(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) <=> (2S)-2-acetolactate + H(+) + NADPH","pmd":612.041}
{"X":3807,"KEGG":"R04439","RHEA_ID":22071,"DIRECTION":"BI","MASTER_ID":22068,"ecocyc":"ACETOLACTREDUCTOISOM-RXN","metacyc":"ACETOLACTREDUCTOISOM-RXN","compounds":"(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) <=> (2S)-2-acetolactate + H(+) + NADPH","pmd":2.016}
{"X":3808,"KEGG":"R04440","RHEA_ID":31142,"DIRECTION":"BI","MASTER_ID":31139,"compounds":"(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) <=> 3-hydroxy-3-methyl-2-oxobutanoate + H(+) + NADPH","pmd":2.016}
{"X":3809,"KEGG":"R04440","RHEA_ID":31142,"DIRECTION":"BI","MASTER_ID":31139,"compounds":"(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) <=> 3-hydroxy-3-methyl-2-oxobutanoate + H(+) + NADPH","pmd":612.041}
{"X":3810,"KEGG":"R04441","RHEA_ID":24812,"DIRECTION":"BI","MASTER_ID":24809,"compounds":"(2R)-2,3-dihydroxy-3-methylbutanoate <=> 3-methyl-2-oxobutanoate + H2O","pmd":18.011}
{"X":3811,"KEGG":"R04444","RHEA_ID":31158,"DIRECTION":"BI","MASTER_ID":31155,"compounds":"(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NAD(+) <=> erythro-4-hydroxy-L-glutamate + H(+) + NADH","pmd":34.006}
{"X":3812,"KEGG":"R04444","RHEA_ID":31158,"DIRECTION":"BI","MASTER_ID":31155,"compounds":"(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NAD(+) <=> erythro-4-hydroxy-L-glutamate + H(+) + NADH","pmd":501.069}
{"X":3813,"KEGG":"R04448","RHEA_ID":24215,"DIRECTION":"BI","MASTER_ID":24212,"compounds":"5-(2-hydroxyethyl)-4-methylthiazole + ATP <=> 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)","pmd":79.966}
{"X":3814,"KEGG":"R04449","RHEA_ID":23791,"DIRECTION":"BI","MASTER_ID":23788,"compounds":"acetate + ATP + holo-[citrate lyase ACP] <=> acetyl-[citrate lyase ACP] + AMP + diphosphate","pmd":159.933}
{"X":3815,"KEGG":"R04450","RHEA_ID":13660,"DIRECTION":"BI","MASTER_ID":13657,"compounds":"acetyl-[citrate lyase ACP] + H2O <=> acetate + H(+) + holo-[citrate lyase ACP]"}
{"X":3816,"KEGG":"R04451","RHEA_ID":14156,"DIRECTION":"BI","MASTER_ID":14153,"compounds":"17alpha-estradiol 3-O-(beta-D-glucuronate) + UDP-N-acetyl-alpha-D-glucosamine <=> 17alpha-(N-acetyl-alpha-D-glucosaminyl)estradiol 3-glucosiduronate + H(+) + UDP","pmd":44.207}
{"X":3817,"KEGG":"R04452","RHEA_ID":17780,"DIRECTION":"BI","MASTER_ID":17777,"compounds":"1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)"}
{"X":3818,"KEGG":"R04453","RHEA_ID":10891,"DIRECTION":"BI","MASTER_ID":10888,"compounds":"4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + H2O + NADP(+) <=> 4-carboxy-2-hydroxy-cis,cis-muconate + 2 H(+) + NADPH","pmd":542.072}
{"X":3819,"KEGG":"R04453","RHEA_ID":10891,"DIRECTION":"BI","MASTER_ID":10888,"compounds":"4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + H2O + NADP(+) <=> 4-carboxy-2-hydroxy-cis,cis-muconate + 2 H(+) + NADPH","pmd":15.995}
{"X":3820,"KEGG":"R04455","RHEA_ID":20020,"DIRECTION":"BI","MASTER_ID":20017,"metacyc":"H2-METHYLENE-THMPT-DEHYDRO-RXN","compounds":"5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2 <=> 5,10-methylenetetrahydromethanopterin + H(+)"}
{"X":3821,"KEGG":"R04456","RHEA_ID":16724,"DIRECTION":"BI","MASTER_ID":16721,"metacyc":"1.5.99.9-RXN","compounds":"5,10-methylenetetrahydromethanopterin + 2 H(+) + oxidized coenzyme F420-(gamma-Glu)(n) <=> 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420-(gamma-Glu)(n)","pmd":13.068}
{"X":3822,"KEGG":"R04456","RHEA_ID":16724,"DIRECTION":"BI","MASTER_ID":16721,"metacyc":"1.5.99.9-RXN","compounds":"5,10-methylenetetrahydromethanopterin + 2 H(+) + oxidized coenzyme F420-(gamma-Glu)(n) <=> 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420-(gamma-Glu)(n)","pmd":2.016}
{"X":3823,"KEGG":"R04457","RHEA_ID":26155,"DIRECTION":"BI","MASTER_ID":26152,"ecocyc":"LUMAZINESYN-RXN","metacyc":"LUMAZINESYN-RXN","compounds":"(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil <=> 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate","pmd":50.016}
{"X":3824,"KEGG":"R04457","RHEA_ID":26155,"DIRECTION":"BI","MASTER_ID":26152,"ecocyc":"LUMAZINESYN-RXN","metacyc":"LUMAZINESYN-RXN","compounds":"(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil <=> 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate","pmd":142.109}
{"X":3825,"KEGG":"R04460","RHEA_ID":24063,"DIRECTION":"BI","MASTER_ID":24060,"compounds":"N-hydroxy-L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":3826,"KEGG":"R04461","RHEA_ID":17048,"DIRECTION":"BI","MASTER_ID":17045,"compounds":"1,2-bis-(3,4-dimethoxyphenyl)propane-1,3-diol + H2O2 <=> 1-(3,4-dimethoxyphenyl)ethane-1,2-diol + 3,4-dimethoxybenzaldehyde + H2O","pmd":150.068}
{"X":3827,"KEGG":"R04463","RHEA_ID":17132,"DIRECTION":"BI","MASTER_ID":17129,"compounds":"ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide <=> 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate","pmd":79.966}
{"X":3828,"KEGG":"R04463","RHEA_ID":17132,"DIRECTION":"BI","MASTER_ID":17129,"compounds":"ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide <=> 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate","pmd":0.984}
{"X":3829,"KEGG":"R04464","RHEA_ID":21147,"DIRECTION":"BI","MASTER_ID":21144,"metacyc":"METHELENE-THMPT-OXI-RXN","compounds":"5-methyl-5,6,7,8-tetrahydromethanopterin + H(+) + oxidized coenzyme F420-(gamma-Glu)(n) <=> 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420-(gamma-Glu)(n)","pmd":2.016}
{"X":3830,"KEGG":"R04466","RHEA_ID":15128,"DIRECTION":"BI","MASTER_ID":15125,"metacyc":"2.3.1.78-RXN","compounds":"acetyl-CoA + alpha-D-glucosaminyl-[heparan sulfate](n) <=> CoA + H(+) + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n)","pmd":42.011}
{"X":3831,"KEGG":"R04467","RHEA_ID":25318,"DIRECTION":"BI","MASTER_ID":25315,"compounds":"2-oxoglutarate + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate <=> L-2-acetamido-6-oxoheptanedioate + L-glutamate","pmd":1.032}
{"X":3832,"KEGG":"R04469","RHEA_ID":10523,"DIRECTION":"BI","MASTER_ID":10520,"compounds":"a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose <=> 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP","pmd":162.053}
{"X":3833,"KEGG":"R04472","RHEA_ID":15924,"DIRECTION":"BI","MASTER_ID":15921,"compounds":"2 a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol <=> a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a 1,2-diacyl-sn-glycerol"}
{"X":3834,"KEGG":"R04473","RHEA_ID":17060,"DIRECTION":"BI","MASTER_ID":17057,"compounds":"a 2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + a fatty acyl-[ACP] <=> a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + holo-[ACP]"}
{"X":3835,"KEGG":"R04475","RHEA_ID":11963,"DIRECTION":"BI","MASTER_ID":11960,"ecocyc":"SUCCINYLDIAMINOPIMTRANS-RXN","metacyc":"SUCCINYLDIAMINOPIMTRANS-RXN","compounds":"2-oxoglutarate + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate <=> (S)-2-succinylamino-6-oxoheptanedioate + L-glutamate","pmd":1.032}
{"X":3836,"KEGG":"R04476","RHEA_ID":14340,"DIRECTION":"BI","MASTER_ID":14337,"metacyc":"2.8.2.7-RXN","compounds":"3'-phosphoadenylyl sulfate + UDP-N-acetyl-alpha-D-galactosamine 4-sulfate <=> adenosine 3',5'-bisphosphate + H(+) + UDP-N-acetyl-alpha-D-galactosamine 4,6-bissulfate","pmd":79.957}
{"X":3837,"KEGG":"R04477","RHEA_ID":28369,"DIRECTION":"BI","MASTER_ID":28366,"compounds":"N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UDP-N-acetyl-alpha-D-mannosaminouronate <=> beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-1-diphospho-di-trans,octa-cis-undecaprenol + H(+) + UDP","pmd":217.059}
{"X":3838,"KEGG":"R04481","RHEA_ID":36422,"DIRECTION":"BI","MASTER_ID":36419,"compounds":"2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine <=> 2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":3839,"KEGG":"R04483","RHEA_ID":34778,"DIRECTION":"BI","MASTER_ID":34775,"compounds":"a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(+) <=> a 3-oxosteroid + CO2 + NADH","pmd":46.005}
{"X":3840,"KEGG":"R04483","RHEA_ID":34778,"DIRECTION":"BI","MASTER_ID":34775,"compounds":"a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(+) <=> a 3-oxosteroid + CO2 + NADH","pmd":265.762}
{"X":3841,"KEGG":"R04483","RHEA_ID":20672,"DIRECTION":"BI","MASTER_ID":20669,"compounds":"3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate + NAD(+) <=> 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADH","pmd":46.005}
{"X":3842,"KEGG":"R04483","RHEA_ID":20672,"DIRECTION":"BI","MASTER_ID":20669,"compounds":"3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate + NAD(+) <=> 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADH","pmd":265.762}
{"X":3843,"KEGG":"R04484","RHEA_ID":11607,"DIRECTION":"BI","MASTER_ID":11604,"metacyc":"POLYSIALIC-ACID-O-ACETYLTRANSFERASE-RXN","compounds":"[(2->8)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA <=> [(2->8)-O(7),N-diacetyl-alpha-D-neuraminosyl](n) + n CoA","pmd":42.011}
{"X":3844,"KEGG":"R04490","RHEA_ID":11551,"DIRECTION":"BI","MASTER_ID":11548,"compounds":"5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene + H2O <=> 5-(4-hydroxy-but-1-ynyl)-2,2'-bithiophene + acetate + H(+)","pmd":42.011}
{"X":3845,"KEGG":"R04491","RHEA_ID":12579,"DIRECTION":"BI","MASTER_ID":12576,"compounds":"(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[procollagen] + UDP-alpha-D-glucose <=> (5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[procollagen] + H(+) + UDP","pmd":162.053}
{"X":3846,"KEGG":"R04493","RHEA_ID":13908,"DIRECTION":"BI","MASTER_ID":13905,"metacyc":"2.4.1.206-RXN","compounds":"a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine <=> a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP","pmd":203.079}
{"X":3847,"KEGG":"R04494","RHEA_ID":23383,"DIRECTION":"BI","MASTER_ID":23380,"compounds":"N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N,N'-diacetylchitobiosyl diphosphodolichol + UDP","pmd":203.079}
{"X":3848,"KEGG":"R04495","RHEA_ID":22935,"DIRECTION":"BI","MASTER_ID":22932,"compounds":"an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP","pmd":162.053}
{"X":3849,"KEGG":"R04496","RHEA_ID":21675,"DIRECTION":"BI","MASTER_ID":21672,"compounds":"[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine <=> [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":3850,"KEGG":"R04498","RHEA_ID":19112,"DIRECTION":"BI","MASTER_ID":19109,"compounds":"1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose <=> 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + D-glucose + H(+)","pmd":152.011}
{"X":3851,"KEGG":"R04501","RHEA_ID":55227,"DIRECTION":"BI","MASTER_ID":55224,"compounds":"4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 4beta-hydroxymethyl-4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O","pmd":15.995}
{"X":3852,"KEGG":"R04502","RHEA_ID":13868,"DIRECTION":"BI","MASTER_ID":13865,"compounds":"GDP-alpha-D-mannose + N,N'-diacetylchitobiosyl diphosphodolichol <=> beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)","pmd":162.053}
{"X":3853,"KEGG":"R04503","RHEA_ID":11071,"DIRECTION":"BI","MASTER_ID":11068,"compounds":"(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[procollagen] + H2O <=> (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[procollagen] + D-glucose"}
{"X":3854,"KEGG":"R04505","RHEA_ID":18720,"DIRECTION":"BI","MASTER_ID":18717,"compounds":"3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine <=> 3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":3855,"KEGG":"R04507","RHEA_ID":21779,"DIRECTION":"BI","MASTER_ID":21776,"compounds":"(25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate + ATP + CoA <=> (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate","pmd":87.276}
{"X":3856,"KEGG":"R04507","RHEA_ID":21779,"DIRECTION":"BI","MASTER_ID":21776,"compounds":"(25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate + ATP + CoA <=> (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate","pmd":420.052}
{"X":3857,"KEGG":"R04507","RHEA_ID":21779,"DIRECTION":"BI","MASTER_ID":21776,"compounds":"(25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate + ATP + CoA <=> (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate","pmd":159.933}
{"X":3858,"KEGG":"R04509","RHEA_ID":19896,"DIRECTION":"BI","MASTER_ID":19893,"compounds":"4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP <=> 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP","pmd":79.966}
{"X":3859,"KEGG":"R04510","RHEA_ID":19240,"DIRECTION":"BI","MASTER_ID":19237,"compounds":"4-carboxymethyl-4-methylbut-2-en-1,4-olide <=> 4-carboxymethyl-3-methylbut-2-en-1,4-olide","pmd":0}
{"X":3860,"KEGG":"R04512","RHEA_ID":15076,"DIRECTION":"BI","MASTER_ID":15073,"compounds":"3-D-glucuronosyl-N(2),6-disulfo-beta-D-glucosamine + H2O <=> D-glucuronate + N(2),6-disulfo-D-glucosamine","pmd":176.032}
{"X":3861,"KEGG":"R04513","RHEA_ID":25020,"DIRECTION":"BI","MASTER_ID":25017,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate"}
{"X":3862,"KEGG":"R04514","RHEA_ID":17472,"DIRECTION":"BI","MASTER_ID":17469,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] <=> a 2-acyl-sn-glycero-3-phosphocholine + an all-trans-retinyl ester + apo--[retinol-binding protein]"}
{"X":3863,"KEGG":"R04517","RHEA_ID":23263,"DIRECTION":"BI","MASTER_ID":23260,"metacyc":"1.1.1.232-RXN","compounds":"(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NAD(+) <=> 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADH","pmd":2.016}
{"X":3864,"KEGG":"R04517","RHEA_ID":23263,"DIRECTION":"BI","MASTER_ID":23260,"metacyc":"1.1.1.232-RXN","compounds":"(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NAD(+) <=> 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADH","pmd":345.897}
{"X":3865,"KEGG":"R04518","RHEA_ID":23267,"DIRECTION":"BI","MASTER_ID":23264,"metacyc":"1.1.1.232-RXN","compounds":"(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NADP(+) <=> 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADPH","pmd":425.864}
{"X":3866,"KEGG":"R04518","RHEA_ID":23267,"DIRECTION":"BI","MASTER_ID":23264,"metacyc":"1.1.1.232-RXN","compounds":"(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NADP(+) <=> 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADPH","pmd":2.016}
{"X":3867,"KEGG":"R04520","RHEA_ID":18112,"DIRECTION":"BI","MASTER_ID":18109,"compounds":"all-trans-geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate <=> 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate + diphosphate","pmd":272.25}
{"X":3868,"KEGG":"R04520","RHEA_ID":18112,"DIRECTION":"BI","MASTER_ID":18109,"compounds":"all-trans-geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate <=> 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate + diphosphate","pmd":266.321}
{"X":3869,"KEGG":"R04522","RHEA_ID":19220,"DIRECTION":"BI","MASTER_ID":19217,"metacyc":"DDT-DEHYDROCHLORINASE-RXN","compounds":"1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane <=> 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H(+)","pmd":35.977}
{"X":3870,"KEGG":"R04524","RHEA_ID":19696,"DIRECTION":"BI","MASTER_ID":19693,"compounds":"5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H2O + NAD(+) <=> 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + 2 H(+) + NADH","pmd":484.087}
{"X":3871,"KEGG":"R04524","RHEA_ID":19696,"DIRECTION":"BI","MASTER_ID":19693,"compounds":"5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H2O + NAD(+) <=> 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + 2 H(+) + NADH","pmd":15.995}
{"X":3872,"KEGG":"R04525","RHEA_ID":16316,"DIRECTION":"BI","MASTER_ID":16313,"compounds":"5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene + H2O <=> 5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene + acetate + H(+)","pmd":42.011}
{"X":3873,"KEGG":"R04526","RHEA_ID":19156,"DIRECTION":"BI","MASTER_ID":19153,"compounds":"apigenin 7-O-beta-D-glucoside + UDP-alpha-D-apiose <=> 7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone + H(+) + UDP","pmd":28.103}
{"X":3874,"KEGG":"R04527","RHEA_ID":21195,"DIRECTION":"BI","MASTER_ID":21192,"metacyc":"3.2.1.97-RXN","compounds":"D-galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine + H2O <=> D-galactosyl-N-acetyl-beta-D-galactosamine + L-serine"}
{"X":3875,"KEGG":"R04527","RHEA_ID":30986,"DIRECTION":"BI","MASTER_ID":30983,"compounds":"H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] <=> beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-seryl-[protein]"}
{"X":3876,"KEGG":"R04529","RHEA_ID":31666,"DIRECTION":"BI","MASTER_ID":31663,"metacyc":"2.6.1.34-RXN","compounds":"2-oxoglutarate + UDP-N-acetylbacillosamine <=> L-glutamate + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose","pmd":1.032}
{"X":3877,"KEGG":"R04532","RHEA_ID":11839,"DIRECTION":"BI","MASTER_ID":11836,"compounds":"CMP-N-acetyl-beta-neuraminate + N-acetyllactosamine <=> CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine","pmd":60.091}
{"X":3878,"KEGG":"R04538","RHEA_ID":21851,"DIRECTION":"BI","MASTER_ID":21848,"compounds":"(E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide <=> (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide","pmd":0}
{"X":3879,"KEGG":"R04540","RHEA_ID":18088,"DIRECTION":"BI","MASTER_ID":18085,"metacyc":"1.8.98.1-RXN","compounds":"coenzyme B + coenzyme M + methanophenazine <=> coenzyme M-coenzyme B heterodisulfide + dihydromethanophenazine","pmd":55.347}
{"X":3880,"KEGG":"R04540","RHEA_ID":18088,"DIRECTION":"BI","MASTER_ID":18085,"metacyc":"1.8.98.1-RXN","compounds":"coenzyme B + coenzyme M + methanophenazine <=> coenzyme M-coenzyme B heterodisulfide + dihydromethanophenazine","pmd":2.016}
{"X":3881,"KEGG":"R04541","RHEA_ID":12535,"DIRECTION":"BI","MASTER_ID":12532,"metacyc":"METHYL-COM-HTP-RXN","compounds":"coenzyme B + methyl-coenzyme M <=> coenzyme M-coenzyme B heterodisulfide + methane","pmd":139.96}
{"X":3882,"KEGG":"R04541","RHEA_ID":12535,"DIRECTION":"BI","MASTER_ID":12532,"metacyc":"METHYL-COM-HTP-RXN","compounds":"coenzyme B + methyl-coenzyme M <=> coenzyme M-coenzyme B heterodisulfide + methane","pmd":327.054}
{"X":3883,"KEGG":"R04545","RHEA_ID":21295,"DIRECTION":"BI","MASTER_ID":21292,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)","pmd":79.966}
{"X":3884,"KEGG":"R04548","RHEA_ID":14352,"DIRECTION":"BI","MASTER_ID":14349,"compounds":"an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-alpha-D-galactose <=> an alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP","pmd":162.053}
{"X":3885,"KEGG":"R04549","RHEA_ID":25216,"DIRECTION":"BI","MASTER_ID":25213,"compounds":"H2O + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine <=> 2-N,3-O-bis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP"}
{"X":3886,"KEGG":"R04550","RHEA_ID":17820,"DIRECTION":"BI","MASTER_ID":17817,"compounds":"(3R)-hydroxytetradecanoyl-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine <=> H(+) + holo-[ACP] + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine"}
{"X":3887,"KEGG":"R04552","RHEA_ID":11639,"DIRECTION":"BI","MASTER_ID":11636,"metacyc":"1.1.1.197-RXN","compounds":"NADP(+) + prostaglandin E1 <=> 15-oxo-prostaglandin E1 + H(+) + NADPH","pmd":2.016}
{"X":3888,"KEGG":"R04552","RHEA_ID":11639,"DIRECTION":"BI","MASTER_ID":11636,"metacyc":"1.1.1.197-RXN","compounds":"NADP(+) + prostaglandin E1 <=> 15-oxo-prostaglandin E1 + H(+) + NADPH","pmd":391.858}
{"X":3889,"KEGG":"R04553","RHEA_ID":23631,"DIRECTION":"BI","MASTER_ID":23628,"compounds":"a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose <=> a beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)","pmd":146.058}
{"X":3890,"KEGG":"R04555","RHEA_ID":23175,"DIRECTION":"BI","MASTER_ID":23172,"metacyc":"2.7.1.109-RXN","compounds":"[3-hydroxy-3-methylglutaryl-coenzyme A reductase]-L-serine + ATP <=> [3-hydroxy-3-methylglutaryl-coenzyme A reductase]-O-phospho-L-serine + ADP + H(+)","pmd":79.966}
{"X":3891,"KEGG":"R04556","RHEA_ID":11919,"DIRECTION":"BI","MASTER_ID":11916,"metacyc":"15-OXOPROSTAGLANDIN-13-REDUCTASE-RXN","compounds":"13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+) <=> 15-oxo-prostaglandin E2 + H(+) + NADH","pmd":313.908}
{"X":3892,"KEGG":"R04556","RHEA_ID":11919,"DIRECTION":"BI","MASTER_ID":11916,"metacyc":"15-OXOPROSTAGLANDIN-13-REDUCTASE-RXN","compounds":"13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+) <=> 15-oxo-prostaglandin E2 + H(+) + NADH","pmd":2.016}
{"X":3893,"KEGG":"R04557","RHEA_ID":11915,"DIRECTION":"BI","MASTER_ID":11912,"metacyc":"15-OXOPROSTAGLANDIN-13-REDUCTASE-RXN","compounds":"13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+) <=> 15-oxo-prostaglandin E2 + H(+) + NADPH","pmd":393.874}
{"X":3894,"KEGG":"R04557","RHEA_ID":11915,"DIRECTION":"BI","MASTER_ID":11912,"metacyc":"15-OXOPROSTAGLANDIN-13-REDUCTASE-RXN","compounds":"13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+) <=> 15-oxo-prostaglandin E2 + H(+) + NADPH","pmd":2.016}
{"X":3895,"KEGG":"R04558","RHEA_ID":24796,"DIRECTION":"BI","MASTER_ID":24793,"compounds":"5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate","pmd":239.019}
{"X":3896,"KEGG":"R04558","RHEA_ID":24796,"DIRECTION":"BI","MASTER_ID":24793,"compounds":"5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate","pmd":0.984}
{"X":3897,"KEGG":"R04559","RHEA_ID":23923,"DIRECTION":"BI","MASTER_ID":23920,"metacyc":"AICARSYN-RXN","compounds":"(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate","pmd":116.011}
{"X":3898,"KEGG":"R04560","RHEA_ID":22195,"DIRECTION":"BI","MASTER_ID":22192,"ecocyc":"AICARTRANSFORM-RXN","metacyc":"AICARTRANSFORM-RXN","compounds":"(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide <=> (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide","pmd":27.995}
{"X":3899,"KEGG":"R04562","RHEA_ID":11759,"DIRECTION":"BI","MASTER_ID":11756,"compounds":"ATP + biotin + L-lysyl-[protein] <=> AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein]","pmd":159.933}
{"X":3900,"KEGG":"R04562","RHEA_ID":11759,"DIRECTION":"BI","MASTER_ID":11756,"compounds":"ATP + biotin + L-lysyl-[protein] <=> AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein]","pmd":102.975}
{"X":3901,"KEGG":"R04563","RHEA_ID":23671,"DIRECTION":"BI","MASTER_ID":23668,"metacyc":"6.3.4.9-RXN","compounds":"apo-[methylmalonyl-CoA:pyruvate carboxytransferase] + ATP + biotin <=> AMP + diphosphate + H(+) + holo-[methylmalonyl-CoA:pyruvate carboxytransferase]","pmd":159.933}
{"X":3902,"KEGG":"R04563","RHEA_ID":23671,"DIRECTION":"BI","MASTER_ID":23668,"metacyc":"6.3.4.9-RXN","compounds":"apo-[methylmalonyl-CoA:pyruvate carboxytransferase] + ATP + biotin <=> AMP + diphosphate + H(+) + holo-[methylmalonyl-CoA:pyruvate carboxytransferase]","pmd":102.975}
{"X":3903,"KEGG":"R04564","RHEA_ID":19316,"DIRECTION":"BI","MASTER_ID":19313,"compounds":"an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP-N-acetyl-beta-neuraminate <=> an N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP + H(+)","pmd":291.095}
{"X":3904,"KEGG":"R04565","RHEA_ID":10463,"DIRECTION":"BI","MASTER_ID":10460,"compounds":"prostaglandin A1 <=> prostaglandin C1","pmd":0}
{"X":3905,"KEGG":"R04567","RHEA_ID":13928,"DIRECTION":"BI","MASTER_ID":13925,"compounds":"(3R)-hydroxytetradecanoyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine <=> holo-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine","pmd":226.193}
{"X":3906,"KEGG":"R04570","RHEA_ID":11155,"DIRECTION":"BI","MASTER_ID":11152,"compounds":"5-pyridoxate + NADPH + O2 <=> 2-(acetamidomethylene)-3-(hydroxymethyl)succinate + NADP(+)","pmd":528.033}
{"X":3907,"KEGG":"R04570","RHEA_ID":11155,"DIRECTION":"BI","MASTER_ID":11152,"compounds":"5-pyridoxate + NADPH + O2 <=> 2-(acetamidomethylene)-3-(hydroxymethyl)succinate + NADP(+)","pmd":34.005}
{"X":3908,"KEGG":"R04571","RHEA_ID":22959,"DIRECTION":"BI","MASTER_ID":22956,"compounds":"1-(1,2-saturated alkyl)-2-acyl-sn-glycero-3-phosphoethanolamine + AH2 + O2 <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + A + 2 H2O"}
{"X":3909,"KEGG":"R04573","RHEA_ID":16088,"DIRECTION":"BI","MASTER_ID":16085,"compounds":"ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine","pmd":79.966}
{"X":3910,"KEGG":"R04573","RHEA_ID":16088,"DIRECTION":"BI","MASTER_ID":16085,"compounds":"ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine","pmd":266.945}
{"X":3911,"KEGG":"R04575","RHEA_ID":18708,"DIRECTION":"BI","MASTER_ID":18705,"compounds":"a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine <=> a beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP","pmd":203.079}
{"X":3912,"KEGG":"R04576","RHEA_ID":10927,"DIRECTION":"BI","MASTER_ID":10924,"compounds":"cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide <=> trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide","pmd":0}
{"X":3913,"KEGG":"R04577","RHEA_ID":19332,"DIRECTION":"BI","MASTER_ID":19329,"compounds":"nuatigenin + UDP-alpha-D-glucose <=> H(+) + nuatigenin 3-beta-D-glucopyranoside + UDP","pmd":26.306}
{"X":3914,"KEGG":"R04579","RHEA_ID":15544,"DIRECTION":"BI","MASTER_ID":15541,"metacyc":"2.4.1.202-RXN","compounds":"DIMBOA + UDP-alpha-D-glucose <=> DIMBOA beta-D-glucoside + H(+) + UDP","pmd":162.053}
{"X":3915,"KEGG":"R04579","RHEA_ID":15544,"DIRECTION":"BI","MASTER_ID":15541,"metacyc":"RXN-7022","compounds":"DIMBOA + UDP-alpha-D-glucose <=> DIMBOA beta-D-glucoside + H(+) + UDP","pmd":162.053}
{"X":3916,"KEGG":"R04580","RHEA_ID":22979,"DIRECTION":"BI","MASTER_ID":22976,"compounds":"(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA <=> (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate","pmd":103.271}
{"X":3917,"KEGG":"R04580","RHEA_ID":22979,"DIRECTION":"BI","MASTER_ID":22976,"compounds":"(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA <=> (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate","pmd":159.933}
{"X":3918,"KEGG":"R04580","RHEA_ID":22979,"DIRECTION":"BI","MASTER_ID":22976,"compounds":"(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA <=> (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate","pmd":420.052}
{"X":3919,"KEGG":"R04581","RHEA_ID":34186,"DIRECTION":"BI","MASTER_ID":34183,"metacyc":"ABEQUOSYLTRANSFERASE-RXN","compounds":"alpha-D-mannosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-beta-D-galactosyl-1-diphosphodecaprenol + CDP-alpha-D-abequose <=> alpha-D-Abe-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-beta-D-Gal-1-diphosphodecaprenol + CDP + H(+)","pmd":130.063}
{"X":3920,"KEGG":"R04582","RHEA_ID":11207,"DIRECTION":"BI","MASTER_ID":11204,"metacyc":"6.3.4.10-RXN","compounds":"apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin <=> AMP + diphosphate + H(+) + holo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)]","pmd":159.933}
{"X":3921,"KEGG":"R04582","RHEA_ID":11207,"DIRECTION":"BI","MASTER_ID":11204,"metacyc":"6.3.4.10-RXN","compounds":"apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin <=> AMP + diphosphate + H(+) + holo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)]","pmd":102.975}
{"X":3922,"KEGG":"R04584","RHEA_ID":12591,"DIRECTION":"BI","MASTER_ID":12588,"compounds":"ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> ganglioside GM2 (d18:1(4E)) + H(+) + UDP","pmd":203.079}
{"X":3923,"KEGG":"R04587","RHEA_ID":25212,"DIRECTION":"BI","MASTER_ID":25209,"compounds":"H2O + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine <=> acetate + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine","pmd":42.011}
{"X":3924,"KEGG":"R04588","RHEA_ID":20396,"DIRECTION":"BI","MASTER_ID":20393,"compounds":"holo-[citrate lyase ACP] + S-acetylphosphopantotheine <=> acetyl-[citrate lyase ACP] + D-pantetheine 4'-phosphate","pmd":42.01}
{"X":3925,"KEGG":"R04590","RHEA_ID":21619,"DIRECTION":"BI","MASTER_ID":21616,"compounds":"a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate <=> an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)","pmd":291.095}
{"X":3926,"KEGG":"R04591","RHEA_ID":22631,"DIRECTION":"BI","MASTER_ID":22628,"compounds":"5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate <=> (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate","pmd":87.983}
{"X":3927,"KEGG":"R04591","RHEA_ID":22631,"DIRECTION":"BI","MASTER_ID":22628,"compounds":"5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate <=> (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate","pmd":52.922}
{"X":3928,"KEGG":"R04591","RHEA_ID":22631,"DIRECTION":"BI","MASTER_ID":22628,"compounds":"5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate <=> (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate","pmd":293.992}
{"X":3929,"KEGG":"R04594","RHEA_ID":24459,"DIRECTION":"BI","MASTER_ID":24456,"compounds":"alpha-ribazole 5'-phosphate + H2O <=> alpha-ribazole + phosphate","pmd":79.966}
{"X":3930,"KEGG":"R04594","RHEA_ID":30370,"DIRECTION":"BI","MASTER_ID":30367,"compounds":"adenosylcob(III)alamin 5'-phosphate + H2O <=> adenosylcob(III)alamin + phosphate","pmd":79.966}
{"X":3931,"KEGG":"R04596","RHEA_ID":52319,"DIRECTION":"BI","MASTER_ID":52316,"compounds":"a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate <=> an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+)","pmd":291.095}
{"X":3932,"KEGG":"R04597","RHEA_ID":21355,"DIRECTION":"BI","MASTER_ID":21352,"compounds":"3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 <=> (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H(+)","pmd":31.99}
{"X":3933,"KEGG":"R04597","RHEA_ID":43899,"DIRECTION":"BI","MASTER_ID":43896,"compounds":"3beta-hydroxy-5alpha-androstan-17-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta,7alpha-dihydroxy-5alpha-androstan-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":31.99}
{"X":3934,"KEGG":"R04602","RHEA_ID":20452,"DIRECTION":"BI","MASTER_ID":20449,"compounds":"5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one + O2 <=> 5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one + 2 H(+)","pmd":31.99}
{"X":3935,"KEGG":"R04603","RHEA_ID":20803,"DIRECTION":"BI","MASTER_ID":20800,"compounds":"3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP","pmd":203.079}
{"X":3936,"KEGG":"R04604","RHEA_ID":24379,"DIRECTION":"BI","MASTER_ID":24376,"metacyc":"6.3.4.11-RXN","compounds":"apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin <=> AMP + diphosphate + H(+) + holo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]","pmd":102.975}
{"X":3937,"KEGG":"R04604","RHEA_ID":24379,"DIRECTION":"BI","MASTER_ID":24376,"metacyc":"6.3.4.11-RXN","compounds":"apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin <=> AMP + diphosphate + H(+) + holo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]","pmd":159.933}
{"X":3938,"KEGG":"R04606","RHEA_ID":22671,"DIRECTION":"BI","MASTER_ID":22668,"compounds":"2-N,3-O-bis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl 1-phosphate + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine <=> H(+) + lipid A disaccharide (E. coli) + UDP","pmd":307.43}
{"X":3939,"KEGG":"R04608","RHEA_ID":16396,"DIRECTION":"BI","MASTER_ID":16393,"compounds":"H2O + juvenile hormone II <=> H(+) + juvenile hormone II carboxylate + methanol","pmd":14.016}
{"X":3940,"KEGG":"R04609","RHEA_ID":16668,"DIRECTION":"BI","MASTER_ID":16665,"compounds":"(5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O <=> (5Z,9E,14Z)-(8xi,11xi,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate","pmd":18.01}
{"X":3941,"KEGG":"R04610","RHEA_ID":16048,"DIRECTION":"BI","MASTER_ID":16045,"metacyc":"2.4.1.86-RXN","compounds":"a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose <=> a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP","pmd":162.053}
{"X":3942,"KEGG":"R04613","RHEA_ID":12435,"DIRECTION":"BI","MASTER_ID":12432,"compounds":"L-alanyl-tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine <=> H(+) + tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-N(6)-(L-alanyl)-L-lysyl-D-alanyl-D-alanine"}
{"X":3943,"KEGG":"R04615","RHEA_ID":13572,"DIRECTION":"BI","MASTER_ID":13569,"compounds":"ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> beta-D-GalNAc-(1->4)-alpha-Neu5Ac-(2->3)-alpha-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer + H(+) + UDP","pmd":203.079}
{"X":3944,"KEGG":"R04617","RHEA_ID":28377,"DIRECTION":"BI","MASTER_ID":28374,"compounds":"ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine","pmd":79.966}
{"X":3945,"KEGG":"R04617","RHEA_ID":28377,"DIRECTION":"BI","MASTER_ID":28374,"compounds":"ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine","pmd":266.945}
{"X":3946,"KEGG":"R04619","RHEA_ID":13708,"DIRECTION":"BI","MASTER_ID":13705,"compounds":"alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + UDP-N-acetyl-alpha-D-glucosamine <=> alpha-D-Man-(1->3)-[alpha-D-GlcNAc-(1->2)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + H(+) + UDP","pmd":203.079}
{"X":3947,"KEGG":"R04621","RHEA_ID":25309,"DIRECTION":"BI","MASTER_ID":25306,"compounds":"7,8-dihydroneopterin + phosphate <=> 7,8-dihydroneopterin 3'-phosphate + H2O","pmd":79.966}
{"X":3948,"KEGG":"R04623","RHEA_ID":15928,"DIRECTION":"BI","MASTER_ID":15925,"metacyc":"DIHYDROBUNOLOL-DEHYDROGENASE-RXN","compounds":"dihydrobunolol + NADP(+) <=> bunolol + H(+) + NADPH","pmd":2.016}
{"X":3949,"KEGG":"R04623","RHEA_ID":15928,"DIRECTION":"BI","MASTER_ID":15925,"metacyc":"DIHYDROBUNOLOL-DEHYDROGENASE-RXN","compounds":"dihydrobunolol + NADP(+) <=> bunolol + H(+) + NADPH","pmd":452.9}
{"X":3950,"KEGG":"R04631","RHEA_ID":16776,"DIRECTION":"BI","MASTER_ID":16773,"compounds":"ganglioside GM2 (d18:1(4E)) + UDP-alpha-D-galactose <=> ganglioside GM1 (d18:1(4E)) + H(+) + UDP","pmd":162.053}
{"X":3951,"KEGG":"R04635","RHEA_ID":53899,"DIRECTION":"BI","MASTER_ID":53896,"compounds":"an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate <=> an N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+)","pmd":291.095}
{"X":3952,"KEGG":"R04636","RHEA_ID":56223,"DIRECTION":"BI","MASTER_ID":56220,"compounds":"3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-seryl-[protein] + H(+) + UDP","pmd":203.079}
{"X":3953,"KEGG":"R04636","RHEA_ID":56227,"DIRECTION":"BI","MASTER_ID":56224,"compounds":"3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-threonyl-[protein] + H(+) + UDP","pmd":203.079}
{"X":3954,"KEGG":"R04638","RHEA_ID":25305,"DIRECTION":"BI","MASTER_ID":25302,"compounds":"7,8-dihydroneopterin 3'-triphosphate + H2O <=> 7,8-dihydroneopterin 3'-phosphate + diphosphate + H(+)","pmd":159.933}
{"X":3955,"KEGG":"R04640","RHEA_ID":15472,"DIRECTION":"BI","MASTER_ID":15469,"compounds":"1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide <=> 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide","pmd":0}
{"X":3956,"KEGG":"R04641","RHEA_ID":14540,"DIRECTION":"BI","MASTER_ID":14537,"compounds":"1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + H(+) + H2O <=> 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + NH4(+)","pmd":0.984}
{"X":3957,"KEGG":"R04643","RHEA_ID":13276,"DIRECTION":"BI","MASTER_ID":13273,"compounds":"3'-phosphoadenylyl sulfate + alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol <=> 6-sulfo-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol + adenosine 3',5'-bisphosphate + H(+)","pmd":79.957}
{"X":3958,"KEGG":"R04648","RHEA_ID":18024,"DIRECTION":"BI","MASTER_ID":18021,"metacyc":"2.4.99.2-RXN","compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)) <=> CMP + ganglioside GD1a (18:1(4E)) + H(+)","pmd":291.095}
{"X":3959,"KEGG":"R04656","RHEA_ID":18916,"DIRECTION":"BI","MASTER_ID":18913,"compounds":"a neolactoside nLc4Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + CMP + H(+)","pmd":291.095}
{"X":3960,"KEGG":"R04657","RHEA_ID":20703,"DIRECTION":"BI","MASTER_ID":20700,"compounds":"ATP + lipid A disaccharide (E. coli) <=> ADP + H(+) + lipid IVA (E. coli)","pmd":79.966}
{"X":3961,"KEGG":"R04658","RHEA_ID":28069,"DIRECTION":"BI","MASTER_ID":28066,"compounds":"CMP-3-deoxy-beta-D-manno-octulosonate + lipid IVA (E. coli) <=> alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)","pmd":220.058}
{"X":3962,"KEGG":"R04659","RHEA_ID":23007,"DIRECTION":"BI","MASTER_ID":23004,"metacyc":"2.4.1.163-RXN","compounds":"a neolactoside nLc4Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine <=> a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + H(+) + UDP","pmd":203.079}
{"X":3963,"KEGG":"R04672","RHEA_ID":24808,"DIRECTION":"BI","MASTER_ID":24805,"compounds":"(2S)-2-acetolactate + thiamine diphosphate <=> 2-(1-hydroxyethyl)thiamine diphosphate + pyruvate","pmd":44.026}
{"X":3964,"KEGG":"R04672","RHEA_ID":24808,"DIRECTION":"BI","MASTER_ID":24805,"compounds":"(2S)-2-acetolactate + thiamine diphosphate <=> 2-(1-hydroxyethyl)thiamine diphosphate + pyruvate","pmd":337.029}
{"X":3965,"KEGG":"R04673","RHEA_ID":33694,"DIRECTION":"BI","MASTER_ID":33691,"compounds":"2-(1-hydroxyethyl)thiamine diphosphate + 2-oxobutanoate <=> (S)-2-ethyl-2-hydroxy-3-oxobutanoate + thiamine diphosphate","pmd":44.026}
{"X":3966,"KEGG":"R04690","RHEA_ID":13776,"DIRECTION":"BI","MASTER_ID":13773,"compounds":"(S)-cheilanthifoline + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-stylopine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]","pmd":2.016}
{"X":3967,"KEGG":"R04692","RHEA_ID":17412,"DIRECTION":"BI","MASTER_ID":17409,"compounds":"(S)-coclaurine + S-adenosyl-L-methionine <=> (S)-N-methylcoclaurine + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":3968,"KEGG":"R04694","RHEA_ID":23579,"DIRECTION":"BI","MASTER_ID":23576,"compounds":"(R)-N-methylcoclaurine + (S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase] <=> berbamunine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]","pmd":297.136}
{"X":3969,"KEGG":"R04695","RHEA_ID":17572,"DIRECTION":"BI","MASTER_ID":17569,"metacyc":"1.5.1.27-RXN","compounds":"(R)-reticuline + NADP(+) <=> 1,2-dehydroreticuline + H(+) + NADPH","pmd":415.928}
{"X":3970,"KEGG":"R04696","RHEA_ID":17716,"DIRECTION":"BI","MASTER_ID":17713,"compounds":"(R)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + salutaridine","pmd":2.016}
{"X":3971,"KEGG":"R04697","RHEA_ID":10111,"DIRECTION":"BI","MASTER_ID":10108,"metacyc":"1.1.1.248-RXN","compounds":"(7S)-salutaridinol + NADP(+) <=> H(+) + NADPH + salutaridine","pmd":2.016}
{"X":3972,"KEGG":"R04697","RHEA_ID":10111,"DIRECTION":"BI","MASTER_ID":10108,"metacyc":"1.1.1.248-RXN","compounds":"(7S)-salutaridinol + NADP(+) <=> H(+) + NADPH + salutaridine","pmd":416.936}
{"X":3973,"KEGG":"R04698","RHEA_ID":13984,"DIRECTION":"BI","MASTER_ID":13981,"compounds":"2 [Fe(III)-cytochrome b561] + CO + H2O <=> 2 [Fe(II)-cytochrome b561] + CO2 + 2 H(+)"}
{"X":3974,"KEGG":"R04699","RHEA_ID":22647,"DIRECTION":"BI","MASTER_ID":22644,"compounds":"O2 + protopine + reduced [NADPH--hemoprotein reductase] <=> 6-hydroxyprotopine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":3975,"KEGG":"R04702","RHEA_ID":10531,"DIRECTION":"BI","MASTER_ID":10528,"compounds":"dihydrosanguinarine + O2 + reduced [NADPH--hemoprotein reductase] <=> 10-hydroxydihydrosanguinarine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":3976,"KEGG":"R04703","RHEA_ID":16624,"DIRECTION":"BI","MASTER_ID":16621,"compounds":"dihydrosanguinarine + H(+) + O2 <=> H2O2 + sanguinarine"}
{"X":3977,"KEGG":"R04705","RHEA_ID":21095,"DIRECTION":"BI","MASTER_ID":21092,"compounds":"12-hydroxydihydrochelirubine + S-adenosyl-L-methionine <=> dihydromacarpine + H(+) + S-adenosyl-L-homocysteine","pmd":5.016}
{"X":3978,"KEGG":"R04706","RHEA_ID":18576,"DIRECTION":"BI","MASTER_ID":18573,"compounds":"dihydrochelirubine + H(+) + O2 <=> chelirubine + H2O2"}
{"X":3979,"KEGG":"R04707","RHEA_ID":18544,"DIRECTION":"BI","MASTER_ID":18541,"compounds":"10-hydroxydihydrosanguinarine + S-adenosyl-L-methionine <=> dihydrochelirubine + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":3980,"KEGG":"R04708","RHEA_ID":10159,"DIRECTION":"BI","MASTER_ID":10156,"compounds":"dihydrochelirubine + O2 + reduced [NADPH--hemoprotein reductase] <=> 12-hydroxydihydrochelirubine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":3981,"KEGG":"R04709","RHEA_ID":19308,"DIRECTION":"BI","MASTER_ID":19305,"compounds":"3-hydroxybenzoyl-CoA + 2 H(+) + 3 malonyl-CoA <=> 2,3',4,6-tetrahydroxybenzophenone + 3 CO2 + 4 CoA","pmd":120.021}
{"X":3982,"KEGG":"R04709","RHEA_ID":19308,"DIRECTION":"BI","MASTER_ID":19305,"compounds":"3-hydroxybenzoyl-CoA + 2 H(+) + 3 malonyl-CoA <=> 2,3',4,6-tetrahydroxybenzophenone + 3 CO2 + 4 CoA","pmd":86}
{"X":3983,"KEGG":"R04710","RHEA_ID":19228,"DIRECTION":"BI","MASTER_ID":19225,"compounds":"glycyl-[formate C-acetyltransferase] + reduced [flavodoxin] + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + glycin-2-yl radical-[formate C-acetyltransferase] + H(+) + L-methionine + semiquinone [flavodoxin]","pmd":147.035}
{"X":3984,"KEGG":"R04711","RHEA_ID":14124,"DIRECTION":"BI","MASTER_ID":14121,"compounds":"3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + S-adenosyl-L-methionine <=> 3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":3985,"KEGG":"R04713","RHEA_ID":13008,"DIRECTION":"BI","MASTER_ID":13005,"compounds":"(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-methionine <=> H(+) + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":3986,"KEGG":"R04714","RHEA_ID":11895,"DIRECTION":"BI","MASTER_ID":11892,"compounds":"6-O-methylnorlaudanosoline + S-adenosyl-L-methionine <=> H(+) + nororientaline + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":3987,"KEGG":"R04716","RHEA_ID":12808,"DIRECTION":"BI","MASTER_ID":12805,"compounds":"(S)-canadine + S-adenosyl-L-methionine <=> (S)-N-methylcanadine + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":3988,"KEGG":"R04716","RHEA_ID":12808,"DIRECTION":"BI","MASTER_ID":12805,"compounds":"(S)-canadine + S-adenosyl-L-methionine <=> (S)-N-methylcanadine + S-adenosyl-L-homocysteine","pmd":15.024}
{"X":3989,"KEGG":"R04718","RHEA_ID":12111,"DIRECTION":"BI","MASTER_ID":12108,"compounds":"L-arginyl-[histone] + S-adenosyl-L-methionine <=> H(+) + N(omega)-methyl-L-arginyl-[histone] + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":3990,"KEGG":"R04719","RHEA_ID":10499,"DIRECTION":"BI","MASTER_ID":10496,"compounds":"L-arginyl-[myelin basic protein] + S-adenosyl-L-methionine <=> H(+) + N(omega)-methyl-L-arginyl-[myelin basic protein] + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":3991,"KEGG":"R04720","RHEA_ID":15412,"DIRECTION":"BI","MASTER_ID":15409,"compounds":"1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine <=> 1-O-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine"}
{"X":3992,"KEGG":"R04721","RHEA_ID":20975,"DIRECTION":"BI","MASTER_ID":20972,"compounds":"1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine <=> 1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine"}
{"X":3993,"KEGG":"R04722","RHEA_ID":11051,"DIRECTION":"BI","MASTER_ID":11048,"compounds":"1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + 1-organyl-2-lyso-sn-glycero-3-phospholipid <=> 1-O-alkyl-sn-glycero-3-phosphocholine + 1-organyl-2-acetyl-sn-glycero-3-phospholipid"}
{"X":3994,"KEGG":"R04723","RHEA_ID":22859,"DIRECTION":"BI","MASTER_ID":22856,"compounds":"(7S)-salutaridinol + acetyl-CoA <=> (7S)-O-acetylsalutaridinol + CoA","pmd":42.011}
{"X":3995,"KEGG":"R04727","RHEA_ID":10355,"DIRECTION":"BI","MASTER_ID":10352,"metacyc":"3.5.1.76-RXN","compounds":"an N-acetylarylalkylamine + H2O <=> acetate + an arylalkylamine"}
{"X":3996,"KEGG":"R04728","RHEA_ID":19772,"DIRECTION":"BI","MASTER_ID":19769,"compounds":"phaseollidin hydrate <=> H2O + phaseollidin","pmd":18.011}
{"X":3997,"KEGG":"R04729","RHEA_ID":12660,"DIRECTION":"BI","MASTER_ID":12657,"metacyc":"5.1.99.4-RXN","compounds":"(2S)-2-methylacyl-CoA <=> (2R)-2-methylacyl-CoA"}
{"X":3998,"KEGG":"R04730","RHEA_ID":17608,"DIRECTION":"BI","MASTER_ID":17605,"compounds":"ATP + C-terminal detyrosinated L-glutamyl-L-glutamyl-[alpha-tubulin] + L-tyrosine <=> ADP + C-terminal L-tyrosyl-L-glutamyl-L-glutamyl-[alpha-tubulin] + H(+) + phosphate","pmd":245.956}
{"X":3999,"KEGG":"R04730","RHEA_ID":17608,"DIRECTION":"BI","MASTER_ID":17605,"compounds":"ATP + C-terminal detyrosinated L-glutamyl-L-glutamyl-[alpha-tubulin] + L-tyrosine <=> ADP + C-terminal L-tyrosyl-L-glutamyl-L-glutamyl-[alpha-tubulin] + H(+) + phosphate","pmd":79.966}
{"X":4000,"KEGG":"R04731","RHEA_ID":22351,"DIRECTION":"BI","MASTER_ID":22348,"compounds":"4-aminoimidazole + H(+) + H2O <=> imidazol-4-one + NH4(+)"}
{"X":4001,"KEGG":"R04733","RHEA_ID":13676,"DIRECTION":"BI","MASTER_ID":13673,"compounds":"[protein-PII]-L-tyrosine + UTP <=> [protein-PII]-uridylyl-L-tyrosine + diphosphate"}
{"X":4002,"KEGG":"R04734","RHEA_ID":11923,"DIRECTION":"BI","MASTER_ID":11920,"compounds":"(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin <=> (6R)-L-erythro-6,7-dihydrobiopterin + H2O","pmd":18.011}
{"X":4003,"KEGG":"R04736","RHEA_ID":14816,"DIRECTION":"BI","MASTER_ID":14813,"metacyc":"5.1.1.15-RXN","compounds":"L-2-aminohexano-6-lactam <=> D-2-aminohexano-6-lactam","pmd":0}
{"X":4004,"KEGG":"R04737","RHEA_ID":31162,"DIRECTION":"BI","MASTER_ID":31159,"compounds":"(3S)-hydroxyhexadecanoyl-CoA + NAD(+) <=> 3-oxohexadecanoyl-CoA + H(+) + NADH"}
{"X":4005,"KEGG":"R04738","RHEA_ID":31166,"DIRECTION":"BI","MASTER_ID":31163,"compounds":"(3S)-hydroxyhexadecanoyl-CoA <=> (2E)-hexadecenoyl-CoA + H2O"}
{"X":4006,"KEGG":"R04739","RHEA_ID":31170,"DIRECTION":"BI","MASTER_ID":31167,"compounds":"(3S)-hydroxytetradecanoyl-CoA + NAD(+) <=> 3-oxotetradecanoyl-CoA + H(+) + NADH","pmd":327.176}
{"X":4007,"KEGG":"R04739","RHEA_ID":31170,"DIRECTION":"BI","MASTER_ID":31167,"compounds":"(3S)-hydroxytetradecanoyl-CoA + NAD(+) <=> 3-oxotetradecanoyl-CoA + H(+) + NADH","pmd":2.016}
{"X":4008,"KEGG":"R04740","RHEA_ID":31174,"DIRECTION":"BI","MASTER_ID":31171,"compounds":"(3S)-hydroxytetradecanoyl-CoA <=> (2E)-tetradecenoyl-CoA + H2O","pmd":18.011}
{"X":4009,"KEGG":"R04741","RHEA_ID":31182,"DIRECTION":"BI","MASTER_ID":31179,"compounds":"(3S)-hydroxydodecanoyl-CoA + NAD(+) <=> 3-oxododecanoyl-CoA + H(+) + NADH","pmd":2.016}
{"X":4010,"KEGG":"R04741","RHEA_ID":31182,"DIRECTION":"BI","MASTER_ID":31179,"compounds":"(3S)-hydroxydodecanoyl-CoA + NAD(+) <=> 3-oxododecanoyl-CoA + H(+) + NADH","pmd":299.145}
{"X":4011,"KEGG":"R04742","RHEA_ID":31186,"DIRECTION":"BI","MASTER_ID":31183,"compounds":"acetyl-CoA + decanoyl-CoA <=> 3-oxododecanoyl-CoA + CoA","pmd":42.01}
{"X":4012,"KEGG":"R04742","RHEA_ID":31186,"DIRECTION":"BI","MASTER_ID":31183,"compounds":"acetyl-CoA + decanoyl-CoA <=> 3-oxododecanoyl-CoA + CoA","pmd":42.011}
{"X":4013,"KEGG":"R04743","RHEA_ID":31190,"DIRECTION":"BI","MASTER_ID":31187,"compounds":"(3S)-hydroxydecanoyl-CoA + NAD(+) <=> 3-oxodecanoyl-CoA + H(+) + NADH","pmd":271.113}
{"X":4014,"KEGG":"R04743","RHEA_ID":31190,"DIRECTION":"BI","MASTER_ID":31187,"compounds":"(3S)-hydroxydecanoyl-CoA + NAD(+) <=> 3-oxodecanoyl-CoA + H(+) + NADH","pmd":2.016}
{"X":4015,"KEGG":"R04744","RHEA_ID":31194,"DIRECTION":"BI","MASTER_ID":31191,"compounds":"(3S)-hydroxydecanoyl-CoA <=> (2E)-decenoyl-CoA + H2O","pmd":18.011}
{"X":4016,"KEGG":"R04745","RHEA_ID":31198,"DIRECTION":"BI","MASTER_ID":31195,"compounds":"(3S)-hydroxyoctanoyl-CoA + NAD(+) <=> 3-oxooctanoyl-CoA + H(+) + NADH","pmd":2.016}
{"X":4017,"KEGG":"R04745","RHEA_ID":31198,"DIRECTION":"BI","MASTER_ID":31195,"compounds":"(3S)-hydroxyoctanoyl-CoA + NAD(+) <=> 3-oxooctanoyl-CoA + H(+) + NADH","pmd":243.082}
{"X":4018,"KEGG":"R04746","RHEA_ID":31202,"DIRECTION":"BI","MASTER_ID":31199,"compounds":"(3S)-hydroxyoctanoyl-CoA <=> (2E)-octenoyl-CoA + H2O","pmd":18.011}
{"X":4019,"KEGG":"R04747","RHEA_ID":31206,"DIRECTION":"BI","MASTER_ID":31203,"compounds":"acetyl-CoA + hexanoyl-CoA <=> 3-oxooctanoyl-CoA + CoA","pmd":42.011}
{"X":4020,"KEGG":"R04747","RHEA_ID":31206,"DIRECTION":"BI","MASTER_ID":31203,"compounds":"acetyl-CoA + hexanoyl-CoA <=> 3-oxooctanoyl-CoA + CoA","pmd":42.01}
{"X":4021,"KEGG":"R04748","RHEA_ID":31146,"DIRECTION":"BI","MASTER_ID":31143,"compounds":"(3S)-hydroxyhexanoyl-CoA + NAD(+) <=> 3-oxohexanoyl-CoA + H(+) + NADH","pmd":2.016}
{"X":4022,"KEGG":"R04748","RHEA_ID":31146,"DIRECTION":"BI","MASTER_ID":31143,"compounds":"(3S)-hydroxyhexanoyl-CoA + NAD(+) <=> 3-oxohexanoyl-CoA + H(+) + NADH","pmd":215.051}
{"X":4023,"KEGG":"R04749","RHEA_ID":30550,"DIRECTION":"BI","MASTER_ID":30547,"compounds":"(3S)-hydroxyhexanoyl-CoA <=> (2E)-hexenoyl-CoA + H2O","pmd":18.011}
{"X":4024,"KEGG":"R04751","RHEA_ID":31210,"DIRECTION":"BI","MASTER_ID":31207,"compounds":"FAD + H(+) + hexanoyl-CoA <=> (2E)-hexenoyl-CoA + FADH2","pmd":2.016}
{"X":4025,"KEGG":"R04754","RHEA_ID":28357,"DIRECTION":"BI","MASTER_ID":28354,"compounds":"decanoyl-CoA + FAD + H(+) <=> (2E)-decenoyl-CoA + FADH2","pmd":2.016}
{"X":4026,"KEGG":"R04759","RHEA_ID":38206,"DIRECTION":"BI","MASTER_ID":38203,"compounds":"19-hydroxyandrost-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-oxo-androst-4-ene-3,17-dione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]","pmd":2.016}
{"X":4027,"KEGG":"R04761","RHEA_ID":38186,"DIRECTION":"BI","MASTER_ID":38183,"compounds":"19-hydroxytestosterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-oxotestosterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]","pmd":2.016}
{"X":4028,"KEGG":"R04768","RHEA_ID":11291,"DIRECTION":"BI","MASTER_ID":11288,"compounds":"dihydromacarpine + H(+) + O2 <=> H2O2 + macarpine"}
{"X":4029,"KEGG":"R04769","RHEA_ID":56911,"DIRECTION":"BI","MASTER_ID":56908,"compounds":"(7S)-O-acetylsalutaridinol <=> acetate + H(+) + thebaine","pmd":60.021}
{"X":4030,"KEGG":"R04771","RHEA_ID":31214,"DIRECTION":"BI","MASTER_ID":31211,"compounds":"ATP + H2O + L-selenomethionine <=> diphosphate + L-adenosylselenomethionine + phosphate","pmd":250.094}
{"X":4031,"KEGG":"R04771","RHEA_ID":31214,"DIRECTION":"BI","MASTER_ID":31211,"compounds":"ATP + H2O + L-selenomethionine <=> diphosphate + L-adenosylselenomethionine + phosphate","pmd":59.906}
{"X":4032,"KEGG":"R04787","RHEA_ID":30610,"DIRECTION":"BI","MASTER_ID":30607,"compounds":"A + all-trans-phytofluene <=> AH2 + all-trans-zeta-carotene","pmd":2.016}
{"X":4033,"KEGG":"R04792","RHEA_ID":15116,"DIRECTION":"BI","MASTER_ID":15113,"metacyc":"RXN-8651","compounds":"5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O <=> 5alpha-cholestane-3beta,5,6beta-triol","pmd":18.01}
{"X":4034,"KEGG":"R04798","RHEA_ID":30614,"DIRECTION":"BI","MASTER_ID":30611,"compounds":"A + all-trans-zeta-carotene <=> AH2 + all-trans-neurosporene","pmd":2.016}
{"X":4035,"KEGG":"R04800","RHEA_ID":15704,"DIRECTION":"BI","MASTER_ID":15701,"compounds":"AH2 + all-trans-neurosporene + O2 <=> A + all-trans-lycopene + 2 H2O","pmd":2.016}
{"X":4036,"KEGG":"R04800","RHEA_ID":30626,"DIRECTION":"BI","MASTER_ID":30623,"compounds":"A + all-trans-neurosporene <=> AH2 + all-trans-lycopene","pmd":2.016}
{"X":4037,"KEGG":"R04807","RHEA_ID":14376,"DIRECTION":"BI","MASTER_ID":14373,"compounds":"5beta-cholestane-3alpha,7alpha,12alpha-triol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + H2O + 2 oxidized [adrenodoxin]","pmd":15.995}
{"X":4038,"KEGG":"R04813","RHEA_ID":18936,"DIRECTION":"BI","MASTER_ID":18933,"compounds":"(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA <=> (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O"}
{"X":4039,"KEGG":"R04826","RHEA_ID":46755,"DIRECTION":"BI","MASTER_ID":46752,"compounds":"7alpha-hydroxycholest-4-en-3-one + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 7alpha,12alpha-dihydroxycholest-4-en-3-one + 2 [Fe(III)-cytochrome b5] + H2O","pmd":15.995}
{"X":4040,"KEGG":"R04855","RHEA_ID":34342,"DIRECTION":"BI","MASTER_ID":34339,"compounds":"22R-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (20R,22R)-20,22-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin]","pmd":15.995}
{"X":4041,"KEGG":"R04856","RHEA_ID":21303,"DIRECTION":"BI","MASTER_ID":21300,"compounds":"H2O + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine <=> a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + sulfate"}
{"X":4042,"KEGG":"R04864","RHEA_ID":10307,"DIRECTION":"BI","MASTER_ID":10304,"metacyc":"ACYLGPEACYLTRANS-RXN","compounds":"a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-[ACP] <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + holo-[ACP]"}
{"X":4043,"KEGG":"R04866","RHEA_ID":54199,"DIRECTION":"BI","MASTER_ID":54196,"compounds":"N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":4044,"KEGG":"R04867","RHEA_ID":54203,"DIRECTION":"BI","MASTER_ID":54200,"compounds":"N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":4045,"KEGG":"R04868","RHEA_ID":20723,"DIRECTION":"BI","MASTER_ID":20720,"metacyc":"2.3.1.164-RXN","compounds":"H2O + isopenicillin N + phenylacetyl-CoA <=> CoA + H(+) + L-2-aminoadipate + penicillin G","pmd":25.016}
{"X":4046,"KEGG":"R04868","RHEA_ID":20723,"DIRECTION":"BI","MASTER_ID":20720,"metacyc":"2.3.1.164-RXN","compounds":"H2O + isopenicillin N + phenylacetyl-CoA <=> CoA + H(+) + L-2-aminoadipate + penicillin G","pmd":118.042}
{"X":4047,"KEGG":"R04870","RHEA_ID":23199,"DIRECTION":"BI","MASTER_ID":23196,"compounds":"3 ATP + H2O + L-2-aminoadipate + L-cysteine + L-valine <=> 3 AMP + 3 diphosphate + 3 H(+) + N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine","pmd":229.984}
{"X":4048,"KEGG":"R04870","RHEA_ID":23199,"DIRECTION":"BI","MASTER_ID":23196,"compounds":"3 ATP + H2O + L-2-aminoadipate + L-cysteine + L-valine <=> 3 AMP + 3 diphosphate + 3 H(+) + N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine","pmd":143.849}
{"X":4049,"KEGG":"R04870","RHEA_ID":23199,"DIRECTION":"BI","MASTER_ID":23196,"compounds":"3 ATP + H2O + L-2-aminoadipate + L-cysteine + L-valine <=> 3 AMP + 3 diphosphate + 3 H(+) + N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine","pmd":226.043}
{"X":4050,"KEGG":"R04870","RHEA_ID":23199,"DIRECTION":"BI","MASTER_ID":23196,"compounds":"3 ATP + H2O + L-2-aminoadipate + L-cysteine + L-valine <=> 3 AMP + 3 diphosphate + 3 H(+) + N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine","pmd":185.994}
{"X":4051,"KEGG":"R04872","RHEA_ID":22431,"DIRECTION":"BI","MASTER_ID":22428,"compounds":"N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 <=> 2 H2O + isopenicillin N","pmd":4.031}
{"X":4052,"KEGG":"R04880","RHEA_ID":31150,"DIRECTION":"BI","MASTER_ID":31147,"compounds":"3,4-dihydroxyphenylethyleneglycol + NAD(+) <=> 3,4-dihydroxymandelaldehyde + H(+) + NADH","pmd":2.016}
{"X":4053,"KEGG":"R04880","RHEA_ID":31150,"DIRECTION":"BI","MASTER_ID":31147,"compounds":"3,4-dihydroxyphenylethyleneglycol + NAD(+) <=> 3,4-dihydroxymandelaldehyde + H(+) + NADH","pmd":496.075}
{"X":4054,"KEGG":"R04884","RHEA_ID":33518,"DIRECTION":"BI","MASTER_ID":33515,"compounds":"2 5,6-dihydroxyindole + O2 <=> 2 H2O + 2 indole-5,6-quinone","pmd":2.016}
{"X":4055,"KEGG":"R04902","RHEA_ID":61103,"DIRECTION":"BI","MASTER_ID":61100,"compounds":"(S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase] <=> (2S)-dihydrotricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":4056,"KEGG":"R04903","RHEA_ID":31218,"DIRECTION":"BI","MASTER_ID":31215,"compounds":"(5-hydroxyindol-3-yl)acetaldehyde + H2O + NAD(+) <=> (5-hydroxyindol-3-yl)acetate + 2 H(+) + NADH","pmd":15.995}
{"X":4057,"KEGG":"R04903","RHEA_ID":31218,"DIRECTION":"BI","MASTER_ID":31215,"compounds":"(5-hydroxyindol-3-yl)acetaldehyde + H2O + NAD(+) <=> (5-hydroxyindol-3-yl)acetate + 2 H(+) + NADH","pmd":473.059}
{"X":4058,"KEGG":"R04909","RHEA_ID":31222,"DIRECTION":"BI","MASTER_ID":31219,"compounds":"5-hydroxykynurenamine + CO2 <=> 5-hydroxy-L-kynurenine + H(+)","pmd":43.99}
{"X":4059,"KEGG":"R04930","RHEA_ID":31154,"DIRECTION":"BI","MASTER_ID":31151,"compounds":"H2O + L-selenocystathionine <=> 2-oxobutanoate + L-selenocysteine + NH4(+)","pmd":101.048}
{"X":4060,"KEGG":"R04950","RHEA_ID":19216,"DIRECTION":"BI","MASTER_ID":19213,"compounds":"acetyl-CoA + an S-substituted L-cysteine <=> an N-acetyl-L-cysteine-S-conjugate + CoA + H(+)","pmd":42.011}
{"X":4061,"KEGG":"R04952","RHEA_ID":42251,"DIRECTION":"BI","MASTER_ID":42248,"compounds":"butanoyl-CoA + H(+) + malonyl-[ACP] <=> 3-oxohexanoyl-[ACP] + CO2 + CoA"}
{"X":4062,"KEGG":"R04972","RHEA_ID":31242,"DIRECTION":"BI","MASTER_ID":31239,"metacyc":"RXN-10642","compounds":"4 H(+) + uroporphyrinogen I <=> 4 CO2 + coproporphyrinogen I","pmd":175.959}
{"X":4063,"KEGG":"R04985","RHEA_ID":41683,"DIRECTION":"BI","MASTER_ID":41680,"metacyc":"RXN-15309","compounds":"a 4-hydroxy-3-all-trans-polyprenylbenzoate + H(+) <=> a 2-all-trans-polyprenylphenol + CO2"}
{"X":4064,"KEGG":"R04986","RHEA_ID":27781,"DIRECTION":"BI","MASTER_ID":27778,"compounds":"4-hydroxy-3-all-trans-octaprenylbenzoate + H(+) <=> 2-all-trans-octaprenylphenol + CO2","pmd":43.99}
{"X":4065,"KEGG":"R04987","RHEA_ID":27793,"DIRECTION":"BI","MASTER_ID":27790,"compounds":"2-all-trans-octaprenylphenol + H(+) + NADPH + O2 <=> 3-(all-trans-octaprenyl)benzene-1,2-diol + H2O + NADP(+)","pmd":15.995}
{"X":4066,"KEGG":"R04987","RHEA_ID":27793,"DIRECTION":"BI","MASTER_ID":27790,"compounds":"2-all-trans-octaprenylphenol + H(+) + NADPH + O2 <=> 3-(all-trans-octaprenyl)benzene-1,2-diol + H2O + NADP(+)","pmd":90.553}
{"X":4067,"KEGG":"R04988","RHEA_ID":27773,"DIRECTION":"BI","MASTER_ID":27770,"compounds":"3-(all-trans-octaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> 2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":4068,"KEGG":"R04990","RHEA_ID":44755,"DIRECTION":"BI","MASTER_ID":44752,"compounds":"2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine <=> 6-methoxy-3-methyl-2-all-trans-hexaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":4069,"KEGG":"R04993","RHEA_ID":26469,"DIRECTION":"BI","MASTER_ID":26466,"compounds":"a 2-demethylmenaquinone + S-adenosyl-L-methionine <=> a menaquinone + H(+) + S-adenosyl-L-homocysteine"}
{"X":4070,"KEGG":"R04998","RHEA_ID":31226,"DIRECTION":"BI","MASTER_ID":31223,"compounds":"cis-beta-D-glucosyl-2-hydroxycinnamate + H2O <=> beta-D-glucose + cis-2-coumarate","pmd":146.037}
{"X":4071,"KEGG":"R05000","RHEA_ID":44507,"DIRECTION":"BI","MASTER_ID":44504,"metacyc":"RXN-11368","compounds":"4-hydroxybenzoate + an all-trans-polyprenyl diphosphate <=> a 4-hydroxy-3-all-trans-polyprenylbenzoate + diphosphate"}
{"X":4072,"KEGG":"R05002","RHEA_ID":29518,"DIRECTION":"BI","MASTER_ID":29515,"compounds":"beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose <=> alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)","pmd":162.053}
{"X":4073,"KEGG":"R05032","RHEA_ID":31230,"DIRECTION":"BI","MASTER_ID":31227,"ecocyc":"NACGLCTRANS-RXN","metacyc":"NACGLCTRANS-RXN","compounds":"N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine-diphosphoundecaprenol + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine + UDP","pmd":203.079}
{"X":4074,"KEGG":"R05049","RHEA_ID":10815,"DIRECTION":"BI","MASTER_ID":10812,"ecocyc":"SUCCGLUALDDEHYD-RXN","metacyc":"SUCCGLUALDDEHYD-RXN","compounds":"H2O + N-succinyl-L-glutamate 5-semialdehyde + NAD(+) <=> 2 H(+) + N-succinyl-L-glutamate + NADH","pmd":15.995}
{"X":4075,"KEGG":"R05049","RHEA_ID":10815,"DIRECTION":"BI","MASTER_ID":10812,"ecocyc":"SUCCGLUALDDEHYD-RXN","metacyc":"SUCCGLUALDDEHYD-RXN","compounds":"H2O + N-succinyl-L-glutamate 5-semialdehyde + NAD(+) <=> 2 H(+) + N-succinyl-L-glutamate + NADH","pmd":417.048}
{"X":4076,"KEGG":"R05050","RHEA_ID":31234,"DIRECTION":"BI","MASTER_ID":31231,"compounds":"4-acetamidobutanal + H2O + NAD(+) <=> 4-acetamidobutanoate + 2 H(+) + NADH","pmd":519.043}
{"X":4077,"KEGG":"R05050","RHEA_ID":31234,"DIRECTION":"BI","MASTER_ID":31231,"compounds":"4-acetamidobutanal + H2O + NAD(+) <=> 4-acetamidobutanoate + 2 H(+) + NADH","pmd":15.995}
{"X":4078,"KEGG":"R05051","RHEA_ID":31246,"DIRECTION":"BI","MASTER_ID":31243,"compounds":"H2O + L-4-hydroxyglutamate semialdehyde + NAD(+) <=> erythro-4-hydroxy-L-glutamate + 2 H(+) + NADH","pmd":518.072}
{"X":4079,"KEGG":"R05051","RHEA_ID":31246,"DIRECTION":"BI","MASTER_ID":31243,"compounds":"H2O + L-4-hydroxyglutamate semialdehyde + NAD(+) <=> erythro-4-hydroxy-L-glutamate + 2 H(+) + NADH","pmd":15.995}
{"X":4080,"KEGG":"R05052","RHEA_ID":31238,"DIRECTION":"BI","MASTER_ID":31235,"compounds":"2-oxoglutarate + erythro-4-hydroxy-L-glutamate <=> (4R)-4-hydroxy-2-oxoglutarate + L-glutamate","pmd":1.032}
{"X":4081,"KEGG":"R05055","RHEA_ID":48619,"DIRECTION":"BI","MASTER_ID":48616,"compounds":"H2O + leukotriene D4 <=> glycine + leukotriene E4","pmd":57.022}
{"X":4082,"KEGG":"R05062","RHEA_ID":31250,"DIRECTION":"BI","MASTER_ID":31247,"compounds":"H(+) + prop-2-ynal + pyrroloquinoline quinol <=> prop-2-yn-1-ol + pyrroloquinoline quinone"}
{"X":4083,"KEGG":"R05064","RHEA_ID":31254,"DIRECTION":"BI","MASTER_ID":31251,"compounds":"(S)-3-hydroxyisobutanoyl-CoA + H2O <=> (S)-3-hydroxy-2-methylpropanoate + CoA + H(+)","pmd":86.037}
{"X":4084,"KEGG":"R05066","RHEA_ID":31278,"DIRECTION":"BI","MASTER_ID":31275,"compounds":"(S)-3-hydroxy-2-methylpropanoate + NAD(+) <=> (S)-methylmalonate semialdehyde + H(+) + NADH","pmd":562.085}
{"X":4085,"KEGG":"R05066","RHEA_ID":31278,"DIRECTION":"BI","MASTER_ID":31275,"compounds":"(S)-3-hydroxy-2-methylpropanoate + NAD(+) <=> (S)-methylmalonate semialdehyde + H(+) + NADH","pmd":2.016}
{"X":4086,"KEGG":"R05069","RHEA_ID":25407,"DIRECTION":"BI","MASTER_ID":25404,"metacyc":"RXN-14106","compounds":"(S)-2-ethyl-2-hydroxy-3-oxobutanoate <=> (R)-3-hydroxy-3-methyl-2-oxopentanoate","pmd":0}
{"X":4087,"KEGG":"R05070","RHEA_ID":27697,"DIRECTION":"BI","MASTER_ID":27694,"compounds":"(2R,3R)-2,3-dihydroxy-3-methylpentanoate <=> (S)-3-methyl-2-oxopentanoate + H2O","pmd":18.011}
{"X":4088,"KEGG":"R05071","RHEA_ID":31258,"DIRECTION":"BI","MASTER_ID":31255,"metacyc":"2-ACETOLACTATE-MUTASE-RXN","compounds":"(2S)-2-acetolactate <=> 3-hydroxy-3-methyl-2-oxobutanoate","pmd":0}
{"X":4089,"KEGG":"R05072","RHEA_ID":15124,"DIRECTION":"BI","MASTER_ID":15121,"metacyc":"2.8.1.5-RXN","compounds":"dithioerythritol + thiosulfate <=> cis-1,2-dithiane-4,5-diol + 2 H(+) + hydrogen sulfide + sulfite","pmd":2.016}
{"X":4090,"KEGG":"R05074","RHEA_ID":28065,"DIRECTION":"BI","MASTER_ID":28062,"compounds":"alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate <=> alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)","pmd":220.058}
{"X":4091,"KEGG":"R05075","RHEA_ID":28441,"DIRECTION":"BI","MASTER_ID":28438,"compounds":"dodecanoyl-(Kdo)2-lipid IVA + tetradecanoyl-[ACP] <=> alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + holo-[ACP]"}
{"X":4092,"KEGG":"R05076","RHEA_ID":38266,"DIRECTION":"BI","MASTER_ID":38263,"metacyc":"RXN-8960","compounds":"(2R,3S)-beta-methylmalyl-CoA <=> 2-methylfumaryl-CoA + H2O","pmd":18.01}
{"X":4093,"KEGG":"R05085","RHEA_ID":16576,"DIRECTION":"BI","MASTER_ID":16573,"ecocyc":"PSERTRANSAMPYR-RXN","metacyc":"PSERTRANSAMPYR-RXN","compounds":"2-oxoglutarate + 4-(phosphooxy)-L-threonine <=> (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate","pmd":1.032}
{"X":4094,"KEGG":"R05086","RHEA_ID":30662,"DIRECTION":"BI","MASTER_ID":30659,"compounds":"4-(phosphooxy)-L-threonine + H2O <=> 4-hydroxy-L-threonine + phosphate","pmd":79.966}
{"X":4095,"KEGG":"R05092","RHEA_ID":22223,"DIRECTION":"BI","MASTER_ID":22220,"compounds":"ent-copalyl diphosphate <=> diphosphate + ent-kaur-16-ene","pmd":177.943}
{"X":4096,"KEGG":"R05092","RHEA_ID":19528,"DIRECTION":"BI","MASTER_ID":19525,"compounds":"(2E,6E)-farnesyl diphosphate <=> (1S,8aR)-delta-cadinene + diphosphate","pmd":177.943}
{"X":4097,"KEGG":"R05097","RHEA_ID":60803,"DIRECTION":"BI","MASTER_ID":60800,"compounds":"2-oxoglutarate + gibberellin A53 + O2 <=> CO2 + gibberellin A44 + succinate","pmd":15.995}
{"X":4098,"KEGG":"R05097","RHEA_ID":60803,"DIRECTION":"BI","MASTER_ID":60800,"compounds":"2-oxoglutarate + gibberellin A53 + O2 <=> CO2 + gibberellin A44 + succinate","pmd":27.995}
{"X":4099,"KEGG":"R05099","RHEA_ID":13400,"DIRECTION":"BI","MASTER_ID":13397,"compounds":"6-oxohexanoate + H2O + NADP(+) <=> 2 H(+) + hexanedioate + NADPH","pmd":598.025}
{"X":4100,"KEGG":"R05099","RHEA_ID":13400,"DIRECTION":"BI","MASTER_ID":13397,"compounds":"6-oxohexanoate + H2O + NADP(+) <=> 2 H(+) + hexanedioate + NADPH","pmd":15.995}
{"X":4101,"KEGG":"R05100","RHEA_ID":26517,"DIRECTION":"BI","MASTER_ID":26514,"metacyc":"RXN-11050","compounds":"cyclohexan-1,2-dione + H2O <=> 6-oxohexanoate + H(+)","pmd":18.011}
{"X":4102,"KEGG":"R05118","RHEA_ID":56395,"DIRECTION":"BI","MASTER_ID":56392,"compounds":"[(3R)-hydroxybutanoate](n) + H2O <=> (3R)-hydroxybutanoate dimer + [(3R)-hydroxybutanoate](n-2) + H(+)"}
{"X":4103,"KEGG":"R05119","RHEA_ID":31262,"DIRECTION":"BI","MASTER_ID":31259,"compounds":"but-3-ynal + H2O + NAD(+) <=> 3-butynoate + 2 H(+) + NADH"}
{"X":4104,"KEGG":"R05121","RHEA_ID":31266,"DIRECTION":"BI","MASTER_ID":31263,"compounds":"but-3-ynal + H(+) + pyrroloquinoline quinol <=> but-3-yn-1-ol + pyrroloquinoline quinone","pmd":2.016}
{"X":4105,"KEGG":"R05123","RHEA_ID":31910,"DIRECTION":"BI","MASTER_ID":31907,"compounds":"(S)-norcoclaurine + S-adenosyl-L-methionine <=> (S)-coclaurine + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":4106,"KEGG":"R05124","RHEA_ID":19212,"DIRECTION":"BI","MASTER_ID":19209,"metacyc":"1.1.1.247-RXN","compounds":"codeine + NADP(+) <=> codeinone + H(+) + NADPH","pmd":2.016}
{"X":4107,"KEGG":"R05124","RHEA_ID":19212,"DIRECTION":"BI","MASTER_ID":19209,"metacyc":"1.1.1.247-RXN","compounds":"codeine + NADP(+) <=> codeinone + H(+) + NADPH","pmd":446.947}
{"X":4108,"KEGG":"R05126","RHEA_ID":27480,"DIRECTION":"BI","MASTER_ID":27477,"compounds":"2-oxoglutarate + O2 + thebaine <=> CO2 + formaldehyde + neopinone + succinate","pmd":27.995}
{"X":4109,"KEGG":"R05126","RHEA_ID":27480,"DIRECTION":"BI","MASTER_ID":27477,"compounds":"2-oxoglutarate + O2 + thebaine <=> CO2 + formaldehyde + neopinone + succinate","pmd":14.016}
{"X":4110,"KEGG":"R05133","RHEA_ID":28513,"DIRECTION":"BI","MASTER_ID":28510,"compounds":"arbutin 6-phosphate + H2O <=> beta-D-glucose 6-phosphate + hydroquinone","pmd":92.026}
{"X":4111,"KEGG":"R05134","RHEA_ID":33130,"DIRECTION":"BI","MASTER_ID":33127,"compounds":"H2O + salicin-6-phosphate <=> beta-D-glucose 6-phosphate + salicyl alcohol","pmd":106.042}
{"X":4112,"KEGG":"R05135","RHEA_ID":27861,"DIRECTION":"BI","MASTER_ID":27858,"compounds":"2',3'-cyclic GMP + H2O <=> 3'-GMP + H(+)","pmd":18.011}
{"X":4113,"KEGG":"R05136","RHEA_ID":27392,"DIRECTION":"BI","MASTER_ID":27389,"compounds":"(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate + H2O <=> pyruvate + salicylaldehyde","pmd":70.006}
{"X":4114,"KEGG":"R05137","RHEA_ID":27404,"DIRECTION":"BI","MASTER_ID":27401,"compounds":"2-hydroxychromene-2-carboxylate <=> (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate","pmd":0}
{"X":4115,"KEGG":"R05140","RHEA_ID":13656,"DIRECTION":"BI","MASTER_ID":13653,"metacyc":"LEVANSUCRASE-RXN","compounds":"[6)-beta-D-fructofuranosyl-(2->](n) alpha-D-glucopyranoside + sucrose <=> [6)-beta-D-fructofuranosyl-(2->](n+1) alpha-D-glucopyranoside + D-glucose","pmd":162.053}
{"X":4116,"KEGG":"R05144","RHEA_ID":45143,"DIRECTION":"BI","MASTER_ID":45140,"compounds":"2,3-epoxyphylloquinone + 4-carboxy-L-glutamyl-[protein] + H(+) + H2O <=> CO2 + L-glutamyl-[protein] + O2 + phylloquinol","pmd":13.979}
{"X":4117,"KEGG":"R05145","RHEA_ID":59735,"DIRECTION":"BI","MASTER_ID":59732,"compounds":"biotinyl-5'-AMP + L-lysyl-[protein] <=> AMP + 2 H(+) + N(6)-biotinyl-L-lysyl-[protein]","pmd":226.078}
{"X":4118,"KEGG":"R05146","RHEA_ID":28445,"DIRECTION":"BI","MASTER_ID":28442,"compounds":"alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + dodecanoyl-[ACP] <=> dodecanoyl-(Kdo)2-lipid IVA + holo-[ACP]"}
{"X":4119,"KEGG":"R05147","RHEA_ID":15140,"DIRECTION":"BI","MASTER_ID":15137,"ecocyc":"1.1.1.251-RXN","metacyc":"1.1.1.251-RXN","compounds":"galactitol 1-phosphate + NAD(+) <=> H(+) + keto-L-tagatose 6-phosphate + NADH"}
{"X":4120,"KEGG":"R05148","RHEA_ID":10315,"DIRECTION":"BI","MASTER_ID":10312,"compounds":"H(+) + NADH + O2 + terephthalate <=> (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+)","pmd":34.006}
{"X":4121,"KEGG":"R05148","RHEA_ID":10315,"DIRECTION":"BI","MASTER_ID":10312,"compounds":"H(+) + NADH + O2 + terephthalate <=> (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+)","pmd":465.093}
{"X":4122,"KEGG":"R05149","RHEA_ID":17480,"DIRECTION":"BI","MASTER_ID":17477,"compounds":"precorrin-6B + 2 S-adenosyl-L-methionine <=> CO2 + 3 H(+) + precorrin-8X + 2 S-adenosyl-L-homocysteine","pmd":15.958}
{"X":4123,"KEGG":"R05149","RHEA_ID":17480,"DIRECTION":"BI","MASTER_ID":17477,"compounds":"precorrin-6B + 2 S-adenosyl-L-methionine <=> CO2 + 3 H(+) + precorrin-8X + 2 S-adenosyl-L-homocysteine","pmd":14.016}
{"X":4124,"KEGG":"R05150","RHEA_ID":23411,"DIRECTION":"BI","MASTER_ID":23408,"metacyc":"1.3.1.54-RXN","compounds":"NADP(+) + precorrin-6B <=> 2 H(+) + NADPH + precorrin-6A","pmd":150.27}
{"X":4125,"KEGG":"R05150","RHEA_ID":23411,"DIRECTION":"BI","MASTER_ID":23408,"metacyc":"1.3.1.54-RXN","compounds":"NADP(+) + precorrin-6B <=> 2 H(+) + NADPH + precorrin-6A","pmd":2.016}
{"X":4126,"KEGG":"R05151","RHEA_ID":11591,"DIRECTION":"BI","MASTER_ID":11588,"metacyc":"1.3.99.16-RXN","compounds":"A + H2O + isoquinoline <=> AH2 + isoquinolin-1(2H)-one","pmd":15.995}
{"X":4127,"KEGG":"R05152","RHEA_ID":17752,"DIRECTION":"BI","MASTER_ID":17749,"metacyc":"1.3.99.17-RXN","compounds":"A + H2O + quinoline <=> AH2 + quinolin-2(1H)-one","pmd":15.995}
{"X":4128,"KEGG":"R05154","RHEA_ID":19328,"DIRECTION":"BI","MASTER_ID":19325,"compounds":"H(+) + NADH + O2 + quinolin-4-ol <=> H2O + NAD(+) + quinoline-3,4-diol","pmd":504.077}
{"X":4129,"KEGG":"R05154","RHEA_ID":19328,"DIRECTION":"BI","MASTER_ID":19325,"compounds":"H(+) + NADH + O2 + quinolin-4-ol <=> H2O + NAD(+) + quinoline-3,4-diol","pmd":15.995}
{"X":4130,"KEGG":"R05156","RHEA_ID":23471,"DIRECTION":"BI","MASTER_ID":23468,"compounds":"2-aminobenzenesulfonate + 2 H(+) + NADH + O2 <=> 2,3-dihydroxybenzenesulfonate + NAD(+) + NH4(+)","pmd":16.979}
{"X":4131,"KEGG":"R05156","RHEA_ID":23471,"DIRECTION":"BI","MASTER_ID":23468,"compounds":"2-aminobenzenesulfonate + 2 H(+) + NADH + O2 <=> 2,3-dihydroxybenzenesulfonate + NAD(+) + NH4(+)","pmd":475.131}
{"X":4132,"KEGG":"R05157","RHEA_ID":10979,"DIRECTION":"BI","MASTER_ID":10976,"compounds":"H(+) + NADH + O2 + quinolin-2-ol <=> 5,6-dihydroquinoline-2,5,6-triol + NAD(+)","pmd":34.005}
{"X":4133,"KEGG":"R05157","RHEA_ID":10979,"DIRECTION":"BI","MASTER_ID":10976,"compounds":"H(+) + NADH + O2 + quinolin-2-ol <=> 5,6-dihydroquinoline-2,5,6-triol + NAD(+)","pmd":486.067}
{"X":4134,"KEGG":"R05158","RHEA_ID":22083,"DIRECTION":"BI","MASTER_ID":22080,"compounds":"H(+) + NADH + O2 + quinolin-2-ol <=> H2O + NAD(+) + quinoline-2,8-diol","pmd":504.077}
{"X":4135,"KEGG":"R05158","RHEA_ID":22083,"DIRECTION":"BI","MASTER_ID":22080,"compounds":"H(+) + NADH + O2 + quinolin-2-ol <=> H2O + NAD(+) + quinoline-2,8-diol","pmd":15.995}
{"X":4136,"KEGG":"R05162","RHEA_ID":19944,"DIRECTION":"BI","MASTER_ID":19941,"compounds":"norcoclaurine + S-adenosyl-L-methionine <=> coclaurine + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":4137,"KEGG":"R05163","RHEA_ID":15664,"DIRECTION":"BI","MASTER_ID":15661,"compounds":"(E)-4-coumaroyl-CoA + an anthocyanidin 3,5-di-O-beta-D-glucoside <=> an anthocyanidin 3-O-beta-D-glucoside 5-O-beta-D-[(6-O-(E)-4-coumaroyl)glucoside] + CoA","pmd":146.037}
{"X":4138,"KEGG":"R05164","RHEA_ID":19168,"DIRECTION":"BI","MASTER_ID":19165,"metacyc":"2.4.1.208-RXN","compounds":"a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose <=> 1,2-diacyl-3-O-[alpha-D-glucosyl-(1-> 2)-alpha-D-glucosyl]-sn-glycerol + H(+) + UDP","pmd":162.053}
{"X":4139,"KEGG":"R05165","RHEA_ID":14048,"DIRECTION":"BI","MASTER_ID":14045,"metacyc":"2.7.8.23-RXN","compounds":"1-carboxyvinyl carboxyphosphonate + H(+) <=> 3-(hydrohydroxyphosphoryl)pyruvate + CO2","pmd":43.99}
{"X":4140,"KEGG":"R05166","RHEA_ID":21571,"DIRECTION":"BI","MASTER_ID":21568,"compounds":"beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + H2O <=> beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + lactose","pmd":324.106}
{"X":4141,"KEGG":"R05167","RHEA_ID":18300,"DIRECTION":"BI","MASTER_ID":18297,"metacyc":"3.5.1.79-RXN","compounds":"a phtalamide + H2O <=> a primary amine + phthalate"}
{"X":4142,"KEGG":"R05168","RHEA_ID":18152,"DIRECTION":"BI","MASTER_ID":18149,"compounds":"H2O + N-acetyl-D-galactosamine 6-phosphate <=> acetate + D-galactosamine 6-phosphate","pmd":42.011}
{"X":4143,"KEGG":"R05169","RHEA_ID":15932,"DIRECTION":"BI","MASTER_ID":15929,"compounds":"2 H(+) + 2 H2O + methylenediurea <=> CO2 + N-(hydroxymethyl)urea + 2 NH4(+)"}
{"X":4144,"KEGG":"R05170","RHEA_ID":22243,"DIRECTION":"BI","MASTER_ID":22240,"compounds":"H2O + methylenediurea <=> N-(carboxyaminomethyl)urea + NH4(+)","pmd":0.984}
{"X":4145,"KEGG":"R05171","RHEA_ID":11707,"DIRECTION":"BI","MASTER_ID":11704,"compounds":"2 H(+) + N-(carboxyaminomethyl)urea <=> CO2 + N-(aminomethyl)urea"}
{"X":4146,"KEGG":"R05172","RHEA_ID":13904,"DIRECTION":"BI","MASTER_ID":13901,"compounds":"H2O + N-(aminomethyl)urea <=> N-(hydroxymethyl)urea + NH4(+)"}
{"X":4147,"KEGG":"R05173","RHEA_ID":20516,"DIRECTION":"BI","MASTER_ID":20513,"metacyc":"4.1.1.76-RXN","compounds":"2-aryl-2-methylmalonate + H(+) <=> 2-arylpropionate + CO2"}
{"X":4148,"KEGG":"R05175","RHEA_ID":10663,"DIRECTION":"BI","MASTER_ID":10660,"compounds":"L-seryl-[protein] <=> D-seryl-[protein]"}
{"X":4149,"KEGG":"R05176","RHEA_ID":17580,"DIRECTION":"BI","MASTER_ID":17577,"compounds":"ADP-D-glycero-beta-D-manno-heptose <=> ADP-L-glycero-beta-D-manno-heptose","pmd":0}
{"X":4150,"KEGG":"R05177","RHEA_ID":22515,"DIRECTION":"BI","MASTER_ID":22512,"metacyc":"5.4.1.2-RXN","compounds":"3 H(+) + precorrin-8X <=> hydrogenobyrinate","pmd":0}
{"X":4151,"KEGG":"R05179","RHEA_ID":50999,"DIRECTION":"BI","MASTER_ID":50996,"compounds":"[ribulose-1,5-bisphosphate carboxylase]-L-lysine + 3 S-adenosyl-L-methionine <=> [ribulose-1,5-bisphosphate carboxylase]-N(6),N(6),N(6)-trimethyl-L-lysine + 3 H(+) + 3 S-adenosyl-L-homocysteine","pmd":14.016}
{"X":4152,"KEGG":"R05180","RHEA_ID":12764,"DIRECTION":"BI","MASTER_ID":12761,"metacyc":"2.1.1.131-RXN","compounds":"precorrin-3B + S-adenosyl-L-methionine <=> 3 H(+) + precorrin-4 + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":4153,"KEGG":"R05181","RHEA_ID":22015,"DIRECTION":"BI","MASTER_ID":22012,"compounds":"precorrin-4 + S-adenosyl-L-methionine <=> precorrin-5 + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":4154,"KEGG":"R05182","RHEA_ID":23911,"DIRECTION":"BI","MASTER_ID":23908,"compounds":"2 [methionine synthase]-methylcob(III)alamin + H(+) + NADP(+) + 2 S-adenosyl-L-homocysteine <=> 2 [methionine synthase]-cob(II)alamin + NADPH + 2 S-adenosyl-L-methionine","pmd":360.969}
{"X":4155,"KEGG":"R05182","RHEA_ID":23911,"DIRECTION":"BI","MASTER_ID":23908,"compounds":"2 [methionine synthase]-methylcob(III)alamin + H(+) + NADP(+) + 2 S-adenosyl-L-homocysteine <=> 2 [methionine synthase]-cob(II)alamin + NADPH + 2 S-adenosyl-L-methionine","pmd":14.016}
{"X":4156,"KEGG":"R05183","RHEA_ID":14952,"DIRECTION":"BI","MASTER_ID":14949,"compounds":"A + H2O + quinoline-4-carboxylate <=> 2-oxo-1,2-dihydroquinoline-4-carboxylate + AH2","pmd":15.995}
{"X":4157,"KEGG":"R05185","RHEA_ID":21451,"DIRECTION":"BI","MASTER_ID":21448,"metacyc":"NITROGENASE-RXN","compounds":"16 ATP + 16 H2O + N2 + 8 reduced [2Fe-2S]-[ferredoxin] <=> 16 ADP + 6 H(+) + H2 + 2 NH4(+) + 8 oxidized [2Fe-2S]-[ferredoxin] + 16 phosphate","pmd":79.966}
{"X":4158,"KEGG":"R05186","RHEA_ID":15648,"DIRECTION":"BI","MASTER_ID":15645,"compounds":"16 ATP + 16 H2O + N2 + 4 reduced [flavodoxin] <=> 16 ADP + 18 H(+) + H2 + 2 NH4(+) + 4 oxidized [flavodoxin] + 16 phosphate","pmd":79.966}
{"X":4159,"KEGG":"R05188","RHEA_ID":14996,"DIRECTION":"BI","MASTER_ID":14993,"compounds":"acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH <=> a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+)","pmd":42.011}
{"X":4160,"KEGG":"R05188","RHEA_ID":14996,"DIRECTION":"BI","MASTER_ID":14993,"compounds":"acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH <=> a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+)","pmd":86}
{"X":4161,"KEGG":"R05188","RHEA_ID":14996,"DIRECTION":"BI","MASTER_ID":14993,"compounds":"acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH <=> a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+)","pmd":22.024}
{"X":4162,"KEGG":"R05190","RHEA_ID":22899,"DIRECTION":"BI","MASTER_ID":22896,"compounds":"acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH <=> a long-chain fatty acyl-CoA + n CO2 + n CoA + H2O + 2n NADP(+)","pmd":42.011}
{"X":4163,"KEGG":"R05190","RHEA_ID":22899,"DIRECTION":"BI","MASTER_ID":22896,"compounds":"acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH <=> a long-chain fatty acyl-CoA + n CO2 + n CoA + H2O + 2n NADP(+)","pmd":86}
{"X":4164,"KEGG":"R05190","RHEA_ID":22899,"DIRECTION":"BI","MASTER_ID":22896,"compounds":"acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH <=> a long-chain fatty acyl-CoA + n CO2 + n CoA + H2O + 2n NADP(+)","pmd":22.024}
{"X":4165,"KEGG":"R05198","RHEA_ID":62203,"DIRECTION":"BI","MASTER_ID":62200,"compounds":"2 [Fe(III)cytochrome c] + ethanol <=> 2 [Fe(II)cytochrome c] + acetaldehyde + 2 H(+)"}
{"X":4166,"KEGG":"R05199","RHEA_ID":49243,"DIRECTION":"BI","MASTER_ID":49240,"compounds":"N(pros)-phospho-L-histidyl-[protein] + N-acetyl-D-glucosamine(out) <=> L-histidyl-[protein] + N-acetyl-D-glucosamine 6-phosphate(in)","pmd":79.966}
{"X":4167,"KEGG":"R05202","RHEA_ID":20316,"DIRECTION":"BI","MASTER_ID":20313,"compounds":"1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP <=> 1D-myo-inositol hexakisphosphate + ADP + H(+)","pmd":79.966}
{"X":4168,"KEGG":"R05209","RHEA_ID":18764,"DIRECTION":"BI","MASTER_ID":18761,"compounds":"a 1,2-diacyl-sn-glycerol + H2O <=> a fatty acid + a monoacylglycerol + H(+)"}
{"X":4169,"KEGG":"R05217","RHEA_ID":17296,"DIRECTION":"BI","MASTER_ID":17293,"compounds":"2 H(+) + NADH + O2 + precorrin-3A <=> H2O + NAD(+) + precorrin-3B","pmd":15.995}
{"X":4170,"KEGG":"R05217","RHEA_ID":17296,"DIRECTION":"BI","MASTER_ID":17293,"compounds":"2 H(+) + NADH + O2 + precorrin-3A <=> H2O + NAD(+) + precorrin-3B","pmd":229.192}
{"X":4171,"KEGG":"R05218","RHEA_ID":24303,"DIRECTION":"BI","MASTER_ID":24300,"compounds":"2 cob(I)yrinate a,c diamide + FMN + 3 H(+) <=> 2 cob(II)yrinate a,c diamide + FMNH2","pmd":2.016}
{"X":4172,"KEGG":"R05218","RHEA_ID":24303,"DIRECTION":"BI","MASTER_ID":24300,"compounds":"2 cob(I)yrinate a,c diamide + FMN + 3 H(+) <=> 2 cob(II)yrinate a,c diamide + FMNH2","pmd":0}
{"X":4173,"KEGG":"R05219","RHEA_ID":18264,"DIRECTION":"BI","MASTER_ID":18261,"compounds":"H2O + precorrin-5 + S-adenosyl-L-methionine <=> acetate + 2 H(+) + precorrin-6A + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":4174,"KEGG":"R05219","RHEA_ID":18264,"DIRECTION":"BI","MASTER_ID":18261,"compounds":"H2O + precorrin-5 + S-adenosyl-L-methionine <=> acetate + 2 H(+) + precorrin-6A + S-adenosyl-L-homocysteine","pmd":27.995}
{"X":4175,"KEGG":"R05220","RHEA_ID":11531,"DIRECTION":"BI","MASTER_ID":11528,"compounds":"2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] <=> 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate"}
{"X":4176,"KEGG":"R05221","RHEA_ID":15772,"DIRECTION":"BI","MASTER_ID":15769,"compounds":"adenosylcob(III)inamide + ATP <=> adenosylcob(III)inamide phosphate + ADP + H(+)","pmd":79.966}
{"X":4177,"KEGG":"R05222","RHEA_ID":22715,"DIRECTION":"BI","MASTER_ID":22712,"metacyc":"COBINPGUANYLYLTRANS-RXN","compounds":"adenosylcob(III)inamide phosphate + GTP + H(+) <=> adenosylcob(III)inamide-GDP + diphosphate"}
{"X":4178,"KEGG":"R05223","RHEA_ID":16052,"DIRECTION":"BI","MASTER_ID":16049,"metacyc":"COBALAMINSYN-RXN","compounds":"adenosylcob(III)inamide-GDP + alpha-ribazole <=> adenosylcob(III)alamin + GMP + H(+)","pmd":84.931}
{"X":4179,"KEGG":"R05224","RHEA_ID":12547,"DIRECTION":"BI","MASTER_ID":12544,"metacyc":"R341-RXN","compounds":"2 ATP + 2 H2O + hydrogenobyrinate + 2 L-glutamine <=> 2 ADP + 2 H(+) + hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 phosphate","pmd":79.966}
{"X":4180,"KEGG":"R05224","RHEA_ID":12547,"DIRECTION":"BI","MASTER_ID":12544,"metacyc":"R341-RXN","compounds":"2 ATP + 2 H2O + hydrogenobyrinate + 2 L-glutamine <=> 2 ADP + 2 H(+) + hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 phosphate","pmd":0.984}
{"X":4181,"KEGG":"R05224","RHEA_ID":12547,"DIRECTION":"BI","MASTER_ID":12544,"metacyc":"R341-RXN","compounds":"2 ATP + 2 H2O + hydrogenobyrinate + 2 L-glutamine <=> 2 ADP + 2 H(+) + hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 phosphate","pmd":1.968}
{"X":4182,"KEGG":"R05225","RHEA_ID":23259,"DIRECTION":"BI","MASTER_ID":23256,"compounds":"adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H2O + 4 L-glutamine <=> adenosylcob(III)yrate + 4 ADP + 4 H(+) + 4 L-glutamate + 4 phosphate","pmd":0.984}
{"X":4183,"KEGG":"R05225","RHEA_ID":23259,"DIRECTION":"BI","MASTER_ID":23256,"compounds":"adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H2O + 4 L-glutamine <=> adenosylcob(III)yrate + 4 ADP + 4 H(+) + 4 L-glutamate + 4 phosphate","pmd":79.966}
{"X":4184,"KEGG":"R05226","RHEA_ID":23507,"DIRECTION":"BI","MASTER_ID":23504,"compounds":"adenosylcob(III)inamide + H2O <=> (R)-1-aminopropan-2-ol + adenosylcob(III)yrate"}
{"X":4185,"KEGG":"R05227","RHEA_ID":15344,"DIRECTION":"BI","MASTER_ID":15341,"compounds":"ATP + Co(2+) + H2O + hydrogenobyrinate a,c-diamide <=> ADP + cob(II)yrinate a,c diamide + 5 H(+) + phosphate","pmd":57.925}
{"X":4186,"KEGG":"R05227","RHEA_ID":15344,"DIRECTION":"BI","MASTER_ID":15341,"compounds":"ATP + Co(2+) + H2O + hydrogenobyrinate a,c-diamide <=> ADP + cob(II)yrinate a,c diamide + 5 H(+) + phosphate","pmd":79.966}
{"X":4187,"KEGG":"R05229","RHEA_ID":16808,"DIRECTION":"BI","MASTER_ID":16805,"compounds":"2-oxoglutarate + deacetoxycephalosporin C + O2 <=> CO2 + deacetylcephalosporin C + succinate","pmd":27.995}
{"X":4188,"KEGG":"R05229","RHEA_ID":16808,"DIRECTION":"BI","MASTER_ID":16805,"compounds":"2-oxoglutarate + deacetoxycephalosporin C + O2 <=> CO2 + deacetylcephalosporin C + succinate","pmd":15.995}
{"X":4189,"KEGG":"R05231","RHEA_ID":31270,"DIRECTION":"BI","MASTER_ID":31267,"compounds":"6-hydroxyhexanoate + NADP(+) <=> 6-oxohexanoate + H(+) + NADPH","pmd":614.02}
{"X":4190,"KEGG":"R05231","RHEA_ID":31270,"DIRECTION":"BI","MASTER_ID":31267,"compounds":"6-hydroxyhexanoate + NADP(+) <=> 6-oxohexanoate + H(+) + NADPH","pmd":2.016}
{"X":4191,"KEGG":"R05236","RHEA_ID":22423,"DIRECTION":"BI","MASTER_ID":22420,"compounds":"cis,trans-4-hydroxymuconate semialdehyde + H2O + NAD(+) <=> 2 H(+) + maleylacetate + NADH","pmd":506.095}
{"X":4192,"KEGG":"R05236","RHEA_ID":22423,"DIRECTION":"BI","MASTER_ID":22420,"compounds":"cis,trans-4-hydroxymuconate semialdehyde + H2O + NAD(+) <=> 2 H(+) + maleylacetate + NADH","pmd":15.995}
{"X":4193,"KEGG":"R05239","RHEA_ID":17036,"DIRECTION":"BI","MASTER_ID":17033,"compounds":"(2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+) <=> biphenyl-2,3-diol + H(+) + NADH","pmd":2.016}
{"X":4194,"KEGG":"R05239","RHEA_ID":17036,"DIRECTION":"BI","MASTER_ID":17033,"compounds":"(2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+) <=> biphenyl-2,3-diol + H(+) + NADH","pmd":478.049}
{"X":4195,"KEGG":"R05240","RHEA_ID":23775,"DIRECTION":"BI","MASTER_ID":23772,"metacyc":"RXN-665","compounds":"(2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+) <=> 2,3-dihydroxy-p-cumate + H(+) + NADH","pmd":468.043}
{"X":4196,"KEGG":"R05240","RHEA_ID":23775,"DIRECTION":"BI","MASTER_ID":23772,"metacyc":"RXN-665","compounds":"(2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+) <=> 2,3-dihydroxy-p-cumate + H(+) + NADH","pmd":2.016}
{"X":4197,"KEGG":"R05244","RHEA_ID":23491,"DIRECTION":"BI","MASTER_ID":23488,"compounds":"1,4-benzoquinone + H(+) + NADPH <=> hydroquinone + NADP(+)","pmd":635.054}
{"X":4198,"KEGG":"R05244","RHEA_ID":23491,"DIRECTION":"BI","MASTER_ID":23488,"compounds":"1,4-benzoquinone + H(+) + NADPH <=> hydroquinone + NADP(+)","pmd":2.016}
{"X":4199,"KEGG":"R05246","RHEA_ID":34166,"DIRECTION":"BI","MASTER_ID":34163,"compounds":"hydroquinone + O2 <=> (2E,4Z)-4-hydroxy-6-oxohexa-2,4-dienoate + H(+)","pmd":31.99}
{"X":4200,"KEGG":"R05247","RHEA_ID":42347,"DIRECTION":"BI","MASTER_ID":42344,"compounds":"H(+) + NADH + O2 + p-cumate <=> (2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+)","pmd":467.036}
{"X":4201,"KEGG":"R05247","RHEA_ID":42347,"DIRECTION":"BI","MASTER_ID":42344,"compounds":"H(+) + NADH + O2 + p-cumate <=> (2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+)","pmd":34.006}
{"X":4202,"KEGG":"R05248","RHEA_ID":42571,"DIRECTION":"BI","MASTER_ID":42568,"compounds":"2,3-dihydroxy-p-cumate + O2 <=> 3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+)","pmd":31.99}
{"X":4203,"KEGG":"R05249","RHEA_ID":48831,"DIRECTION":"BI","MASTER_ID":48828,"compounds":"H(+) + NADPH + O2 + resorcinol <=> benzene-1,2,4-triol + H2O + NADP(+)","pmd":15.995}
{"X":4204,"KEGG":"R05249","RHEA_ID":48831,"DIRECTION":"BI","MASTER_ID":48828,"compounds":"H(+) + NADPH + O2 + resorcinol <=> benzene-1,2,4-triol + H2O + NADP(+)","pmd":619.059}
{"X":4205,"KEGG":"R05258","RHEA_ID":34330,"DIRECTION":"BI","MASTER_ID":34327,"compounds":"4-nitrophenol + H(+) + NADPH + O2 <=> 1,4-benzoquinone + H2O + NADP(+) + nitrite","pmd":605.056}
{"X":4206,"KEGG":"R05258","RHEA_ID":34330,"DIRECTION":"BI","MASTER_ID":34327,"compounds":"4-nitrophenol + H(+) + NADPH + O2 <=> 1,4-benzoquinone + H2O + NADP(+) + nitrite","pmd":31.006}
{"X":4207,"KEGG":"R05263","RHEA_ID":18168,"DIRECTION":"BI","MASTER_ID":18165,"compounds":"biphenyl + H(+) + NADH + O2 <=> (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+)","pmd":477.041}
{"X":4208,"KEGG":"R05263","RHEA_ID":18168,"DIRECTION":"BI","MASTER_ID":18165,"compounds":"biphenyl + H(+) + NADH + O2 <=> (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+)","pmd":34.005}
{"X":4209,"KEGG":"R05266","RHEA_ID":51607,"DIRECTION":"BI","MASTER_ID":51604,"compounds":"2 H(+) + O2 + p-cymene + 2 reduced [2Fe-2S]-[ferredoxin] <=> 4-isopropylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]","pmd":15.995}
{"X":4210,"KEGG":"R05267","RHEA_ID":53019,"DIRECTION":"BI","MASTER_ID":53016,"metacyc":"RXN-12506","compounds":"chlorohydroquinone + 2 glutathione <=> chloride + glutathione disulfide + H(+) + hydroquinone","pmd":305.068}
{"X":4211,"KEGG":"R05267","RHEA_ID":53019,"DIRECTION":"BI","MASTER_ID":53016,"metacyc":"RXN-12506","compounds":"chlorohydroquinone + 2 glutathione <=> chloride + glutathione disulfide + H(+) + hydroquinone","pmd":33.961}
{"X":4212,"KEGG":"R05269","RHEA_ID":53015,"DIRECTION":"BI","MASTER_ID":53012,"metacyc":"LIND-RXN","compounds":"2,5-dichlorohydroquinone + 2 glutathione <=> chloride + chlorohydroquinone + glutathione disulfide + H(+)","pmd":163.086}
{"X":4213,"KEGG":"R05269","RHEA_ID":53015,"DIRECTION":"BI","MASTER_ID":53012,"metacyc":"LIND-RXN","compounds":"2,5-dichlorohydroquinone + 2 glutathione <=> chloride + chlorohydroquinone + glutathione disulfide + H(+)","pmd":33.961}
{"X":4214,"KEGG":"R05270","RHEA_ID":40302,"DIRECTION":"BI","MASTER_ID":40299,"compounds":"6-deoxyerythronolide B + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> erythronolide B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]","pmd":15.995}
{"X":4215,"KEGG":"R05271","RHEA_ID":24415,"DIRECTION":"BI","MASTER_ID":24412,"metacyc":"SOLDEHYD-RXN","compounds":"4-(hydroxymethyl)benzenesulfonate + NAD(+) <=> 4-formylbenzenesulfonate + H(+) + NADH","pmd":478.118}
{"X":4216,"KEGG":"R05271","RHEA_ID":24415,"DIRECTION":"BI","MASTER_ID":24412,"metacyc":"SOLDEHYD-RXN","compounds":"4-(hydroxymethyl)benzenesulfonate + NAD(+) <=> 4-formylbenzenesulfonate + H(+) + NADH","pmd":2.016}
{"X":4217,"KEGG":"R05272","RHEA_ID":18836,"DIRECTION":"BI","MASTER_ID":18833,"metacyc":"SYDDEHYD-RXN","compounds":"4-formylbenzenesulfonate + H2O + NAD(+) <=> 4-sulfobenzoate + 2 H(+) + NADH","pmd":15.995}
{"X":4218,"KEGG":"R05272","RHEA_ID":18836,"DIRECTION":"BI","MASTER_ID":18833,"metacyc":"SYDDEHYD-RXN","compounds":"4-formylbenzenesulfonate + H2O + NAD(+) <=> 4-sulfobenzoate + 2 H(+) + NADH","pmd":462.123}
{"X":4219,"KEGG":"R05274","RHEA_ID":13024,"DIRECTION":"BI","MASTER_ID":13021,"compounds":"4-hydroxy-3-methoxybenzoate + H(+) + NADH + O2 <=> 3,4-dihydroxybenzoate + formaldehyde + H2O + NAD(+)","pmd":14.016}
{"X":4220,"KEGG":"R05274","RHEA_ID":13024,"DIRECTION":"BI","MASTER_ID":13021,"compounds":"4-hydroxy-3-methoxybenzoate + H(+) + NADH + O2 <=> 3,4-dihydroxybenzoate + formaldehyde + H2O + NAD(+)","pmd":511.098}
{"X":4221,"KEGG":"R05275","RHEA_ID":13840,"DIRECTION":"BI","MASTER_ID":13837,"compounds":"cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+) <=> 4,5-dihydroxyphthalate + H(+) + NADH","pmd":466.101}
{"X":4222,"KEGG":"R05275","RHEA_ID":13840,"DIRECTION":"BI","MASTER_ID":13837,"compounds":"cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+) <=> 4,5-dihydroxyphthalate + H(+) + NADH","pmd":2.016}
{"X":4223,"KEGG":"R05276","RHEA_ID":23079,"DIRECTION":"BI","MASTER_ID":23076,"compounds":"4-chlorobenzoyl-CoA + chloride + NADP(+) <=> 2,4-dichlorobenzoyl-CoA + NADPH","pmd":33.961}
{"X":4224,"KEGG":"R05276","RHEA_ID":23079,"DIRECTION":"BI","MASTER_ID":23076,"compounds":"4-chlorobenzoyl-CoA + chloride + NADP(+) <=> 2,4-dichlorobenzoyl-CoA + NADPH","pmd":194.98}
{"X":4225,"KEGG":"R05281","RHEA_ID":51027,"DIRECTION":"BI","MASTER_ID":51024,"compounds":"H(+) + NADH + O2 + toluene-4-sulfonate <=> 4-(hydroxymethyl)benzenesulfonate + H2O + NAD(+)","pmd":15.995}
{"X":4226,"KEGG":"R05281","RHEA_ID":51027,"DIRECTION":"BI","MASTER_ID":51024,"compounds":"H(+) + NADH + O2 + toluene-4-sulfonate <=> 4-(hydroxymethyl)benzenesulfonate + H2O + NAD(+)","pmd":477.111}
{"X":4227,"KEGG":"R05283","RHEA_ID":14228,"DIRECTION":"BI","MASTER_ID":14225,"compounds":"6-hydroxyhexanoate + NAD(+) <=> 6-oxohexanoate + H(+) + NADH","pmd":2.016}
{"X":4228,"KEGG":"R05283","RHEA_ID":14228,"DIRECTION":"BI","MASTER_ID":14225,"compounds":"6-hydroxyhexanoate + NAD(+) <=> 6-oxohexanoate + H(+) + NADH","pmd":534.054}
{"X":4229,"KEGG":"R05284","RHEA_ID":25188,"DIRECTION":"BI","MASTER_ID":25185,"compounds":"1,2-dichloroethane + H2O <=> 2-chloroethanol + chloride + H(+)"}
{"X":4230,"KEGG":"R05285","RHEA_ID":55947,"DIRECTION":"BI","MASTER_ID":55944,"metacyc":"MOXXANAU-RXN","compounds":"2-chloroethanol + 2 [Fe(III)cytochrome c] <=> 2 [Fe(II)cytochrome c] + chloroacetaldehyde + 2 H(+)"}
{"X":4231,"KEGG":"R05286","RHEA_ID":30050,"DIRECTION":"BI","MASTER_ID":30047,"compounds":"chloroacetaldehyde + H2O + NAD(+) <=> chloroacetate + 2 H(+) + NADH"}
{"X":4232,"KEGG":"R05287","RHEA_ID":25192,"DIRECTION":"BI","MASTER_ID":25189,"compounds":"chloroacetate + H2O <=> chloride + glycolate + H(+)"}
{"X":4233,"KEGG":"R05288","RHEA_ID":51599,"DIRECTION":"BI","MASTER_ID":51596,"compounds":"2 H(+) + O2 + p-xylene + 2 reduced [2Fe-2S]-[ferredoxin] <=> 4-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]","pmd":15.995}
{"X":4234,"KEGG":"R05292","RHEA_ID":24231,"DIRECTION":"BI","MASTER_ID":24228,"compounds":"(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NAD(+) <=> 4-methylcatechol + CO2 + NADH","pmd":46.005}
{"X":4235,"KEGG":"R05292","RHEA_ID":24231,"DIRECTION":"BI","MASTER_ID":24228,"compounds":"(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NAD(+) <=> 4-methylcatechol + CO2 + NADH","pmd":540.064}
{"X":4236,"KEGG":"R05293","RHEA_ID":24227,"DIRECTION":"BI","MASTER_ID":24224,"compounds":"(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NADP(+) <=> 4-methylcatechol + CO2 + NADPH","pmd":620.031}
{"X":4237,"KEGG":"R05293","RHEA_ID":24227,"DIRECTION":"BI","MASTER_ID":24224,"compounds":"(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NADP(+) <=> 4-methylcatechol + CO2 + NADPH","pmd":46.005}
{"X":4238,"KEGG":"R05298","RHEA_ID":36006,"DIRECTION":"BI","MASTER_ID":36003,"metacyc":"RXN-12735","compounds":"(S)-4-hydroxy-2-oxohexanoate <=> propanal + pyruvate"}
{"X":4239,"KEGG":"R05301","RHEA_ID":20751,"DIRECTION":"BI","MASTER_ID":20748,"compounds":"2-oxoglutarate + O2 + penicillin N <=> CO2 + deacetoxycephalosporin C + H2O + succinate","pmd":2.016}
{"X":4240,"KEGG":"R05301","RHEA_ID":20751,"DIRECTION":"BI","MASTER_ID":20748,"compounds":"2-oxoglutarate + O2 + penicillin N <=> CO2 + deacetoxycephalosporin C + H2O + succinate","pmd":27.995}
{"X":4241,"KEGG":"R05305","RHEA_ID":11171,"DIRECTION":"BI","MASTER_ID":11168,"metacyc":"1.1.1.259-RXN","compounds":"3-hydroxy-6-carboxyhexanoyl-CoA + NAD(+) <=> 3-oxo-6-carboxyhexanoyl-CoA + H(+) + NADH","pmd":259.041}
{"X":4242,"KEGG":"R05305","RHEA_ID":11171,"DIRECTION":"BI","MASTER_ID":11168,"metacyc":"1.1.1.259-RXN","compounds":"3-hydroxy-6-carboxyhexanoyl-CoA + NAD(+) <=> 3-oxo-6-carboxyhexanoyl-CoA + H(+) + NADH","pmd":2.016}
{"X":4243,"KEGG":"R05307","RHEA_ID":20604,"DIRECTION":"BI","MASTER_ID":20601,"compounds":"formaldehyde + mycothiol + NAD(+) <=> H(+) + NADH + S-formylmycothiol","pmd":149.97}
{"X":4244,"KEGG":"R05307","RHEA_ID":20604,"DIRECTION":"BI","MASTER_ID":20601,"compounds":"formaldehyde + mycothiol + NAD(+) <=> H(+) + NADH + S-formylmycothiol","pmd":27.995}
{"X":4245,"KEGG":"R05308","RHEA_ID":10083,"DIRECTION":"BI","MASTER_ID":10080,"metacyc":"R5-RXN","compounds":"dihydrophloroglucinol + NADP(+) <=> 1,3,5-trihydroxybenzene + NADPH","pmd":2.016}
{"X":4246,"KEGG":"R05308","RHEA_ID":10083,"DIRECTION":"BI","MASTER_ID":10080,"metacyc":"R5-RXN","compounds":"dihydrophloroglucinol + NADP(+) <=> 1,3,5-trihydroxybenzene + NADPH","pmd":618.052}
{"X":4247,"KEGG":"R05310","RHEA_ID":24191,"DIRECTION":"BI","MASTER_ID":24188,"metacyc":"1.3.1.60-RXN","compounds":"cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD(+) <=> 1,2-dihydroxydibenzothiophene + H(+) + NADH","pmd":2.016}
{"X":4248,"KEGG":"R05310","RHEA_ID":24191,"DIRECTION":"BI","MASTER_ID":24188,"metacyc":"1.3.1.60-RXN","compounds":"cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD(+) <=> 1,2-dihydroxydibenzothiophene + H(+) + NADH","pmd":448.092}
{"X":4249,"KEGG":"R05311","RHEA_ID":19668,"DIRECTION":"BI","MASTER_ID":19665,"compounds":"6-carboxyhexanoyl-CoA + NAD(+) <=> 6-carboxyhex-2-enoyl-CoA + H(+) + NADH","pmd":2.016}
{"X":4250,"KEGG":"R05311","RHEA_ID":19668,"DIRECTION":"BI","MASTER_ID":19665,"compounds":"6-carboxyhexanoyl-CoA + NAD(+) <=> 6-carboxyhex-2-enoyl-CoA + H(+) + NADH","pmd":243.046}
{"X":4251,"KEGG":"R05312","RHEA_ID":24559,"DIRECTION":"BI","MASTER_ID":24556,"compounds":"5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one + NAD(+) <=> 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + H(+) + NADH","pmd":473.059}
{"X":4252,"KEGG":"R05312","RHEA_ID":24559,"DIRECTION":"BI","MASTER_ID":24556,"compounds":"5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one + NAD(+) <=> 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + H(+) + NADH","pmd":2.016}
{"X":4253,"KEGG":"R05313","RHEA_ID":18104,"DIRECTION":"BI","MASTER_ID":18101,"compounds":"cis-1,2-dihydro-3-ethylcatechol + NAD(+) <=> 3-ethylcatechol + H(+) + NADH","pmd":2.016}
{"X":4254,"KEGG":"R05313","RHEA_ID":18104,"DIRECTION":"BI","MASTER_ID":18101,"compounds":"cis-1,2-dihydro-3-ethylcatechol + NAD(+) <=> 3-ethylcatechol + H(+) + NADH","pmd":526.049}
{"X":4255,"KEGG":"R05314","RHEA_ID":15660,"DIRECTION":"BI","MASTER_ID":15657,"metacyc":"1.3.1.68-RXN","compounds":"1,6-dihydroxy-2-methylcyclohexa-2,4-dienecarboxylate + NAD(+) <=> 3-methylcatechol + CO2 + NADH","pmd":540.064}
{"X":4256,"KEGG":"R05314","RHEA_ID":15660,"DIRECTION":"BI","MASTER_ID":15657,"metacyc":"1.3.1.68-RXN","compounds":"1,6-dihydroxy-2-methylcyclohexa-2,4-dienecarboxylate + NAD(+) <=> 3-methylcatechol + CO2 + NADH","pmd":46.005}
{"X":4257,"KEGG":"R05315","RHEA_ID":10519,"DIRECTION":"BI","MASTER_ID":10516,"metacyc":"1.1.1.166-RXN","compounds":"(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD(+) <=> (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + H(+) + NADH","pmd":506.059}
{"X":4258,"KEGG":"R05315","RHEA_ID":10519,"DIRECTION":"BI","MASTER_ID":10516,"metacyc":"1.1.1.166-RXN","compounds":"(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD(+) <=> (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + H(+) + NADH","pmd":2.016}
{"X":4259,"KEGG":"R05316","RHEA_ID":29606,"DIRECTION":"BI","MASTER_ID":29603,"compounds":"benzoyl-CoA + H2O + oxidized 2[4Fe-4S]-[ferredoxin] <=> 4-hydroxybenzoyl-CoA + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]","pmd":15.995}
{"X":4260,"KEGG":"R05317","RHEA_ID":19904,"DIRECTION":"BI","MASTER_ID":19901,"metacyc":"1.4.3.17-RXN","compounds":"L-tryptophan + O2 <=> alpha,beta-didehydrotryptophan + H2O2","pmd":2.016}
{"X":4261,"KEGG":"R05318","RHEA_ID":15620,"DIRECTION":"BI","MASTER_ID":15617,"metacyc":"IRON--CYTOCHROME-C-REDUCTASE-RXN","compounds":"[Fe(II)cytochrome c] + Fe(3+) <=> [Fe(III)cytochrome c] + Fe(2+)"}
{"X":4262,"KEGG":"R05320","RHEA_ID":15912,"DIRECTION":"BI","MASTER_ID":15909,"compounds":"2-oxoglutarate + O2 + taurine <=> aminoacetaldehyde + CO2 + H(+) + succinate + sulfite","pmd":6.988}
{"X":4263,"KEGG":"R05320","RHEA_ID":15912,"DIRECTION":"BI","MASTER_ID":15909,"compounds":"2-oxoglutarate + O2 + taurine <=> aminoacetaldehyde + CO2 + H(+) + succinate + sulfite","pmd":27.995}
{"X":4264,"KEGG":"R05321","RHEA_ID":20176,"DIRECTION":"BI","MASTER_ID":20173,"compounds":"H(+) + NADH + O2 + tetradecanoyl-CoA <=> (11E)-tetradecenoyl-CoA + 2 H2O + NAD(+)","pmd":2.016}
{"X":4265,"KEGG":"R05321","RHEA_ID":20176,"DIRECTION":"BI","MASTER_ID":20173,"compounds":"H(+) + NADH + O2 + tetradecanoyl-CoA <=> (11E)-tetradecenoyl-CoA + 2 H2O + NAD(+)","pmd":310.173}
{"X":4266,"KEGG":"R05322","RHEA_ID":14960,"DIRECTION":"BI","MASTER_ID":14957,"compounds":"H(+) + NADH + O2 + tetradecanoyl-CoA <=> (11Z)-tetradecenoyl-CoA + 2 H2O + NAD(+)","pmd":2.016}
{"X":4267,"KEGG":"R05322","RHEA_ID":14960,"DIRECTION":"BI","MASTER_ID":14957,"compounds":"H(+) + NADH + O2 + tetradecanoyl-CoA <=> (11Z)-tetradecenoyl-CoA + 2 H2O + NAD(+)","pmd":310.173}
{"X":4268,"KEGG":"R05323","RHEA_ID":16184,"DIRECTION":"BI","MASTER_ID":16181,"compounds":"3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine <=> 3',4',5-trihydroxy-3,7-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":4269,"KEGG":"R05324","RHEA_ID":13132,"DIRECTION":"BI","MASTER_ID":13129,"compounds":"cis-4-coumarate + UDP-alpha-D-glucose <=> 4'-O-beta-D-glucosyl-cis-4-coumarate + H(+) + UDP","pmd":162.053}
{"X":4270,"KEGG":"R05325","RHEA_ID":11259,"DIRECTION":"BI","MASTER_ID":11256,"compounds":"H2O + limonin + UDP-alpha-D-glucose <=> glucosyl-limonin + 2 H(+) + UDP","pmd":66.192}
{"X":4271,"KEGG":"R05325","RHEA_ID":11259,"DIRECTION":"BI","MASTER_ID":11256,"compounds":"H2O + limonin + UDP-alpha-D-glucose <=> glucosyl-limonin + 2 H(+) + UDP","pmd":84.203}
{"X":4272,"KEGG":"R05326","RHEA_ID":20288,"DIRECTION":"BI","MASTER_ID":20285,"metacyc":"2.4.1.211-RXN","compounds":"beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + phosphate <=> alpha-D-galactose 1-phosphate + N-acetyl-D-glucosamine","pmd":123.113}
{"X":4273,"KEGG":"R05328","RHEA_ID":12884,"DIRECTION":"BI","MASTER_ID":12881,"metacyc":"2.4.1.213-RXN","compounds":"ADP-alpha-D-glucose + sn-glycerol 3-phosphate <=> 2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + ADP + H(+)","pmd":162.053}
{"X":4274,"KEGG":"R05329","RHEA_ID":33302,"DIRECTION":"BI","MASTER_ID":33299,"compounds":"[eIF5A protein]-L-lysine + spermidine <=> [eIF5A protein]-deoxyhypusine + propane-1,3-diamine"}
{"X":4275,"KEGG":"R05330","RHEA_ID":10411,"DIRECTION":"BI","MASTER_ID":10408,"compounds":"4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA <=> 3-oxopristanoyl-CoA + CoA","pmd":56.026}
{"X":4276,"KEGG":"R05331","RHEA_ID":23575,"DIRECTION":"BI","MASTER_ID":23572,"compounds":"3-methylbutanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 3 CO2 + 4 CoA + phlorisovalerophenone","pmd":84.058}
{"X":4277,"KEGG":"R05331","RHEA_ID":23575,"DIRECTION":"BI","MASTER_ID":23572,"compounds":"3-methylbutanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 3 CO2 + 4 CoA + phlorisovalerophenone","pmd":86}
{"X":4278,"KEGG":"R05332","RHEA_ID":13728,"DIRECTION":"BI","MASTER_ID":13725,"compounds":"acetyl-CoA + alpha-D-glucosamine 1-phosphate <=> CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate","pmd":42.011}
{"X":4279,"KEGG":"R05333","RHEA_ID":14060,"DIRECTION":"BI","MASTER_ID":14057,"metacyc":"2.3.1.158-RXN","compounds":"a 1,2-diacyl-sn-glycerol + a glycerophospholipid <=> a monoacylglycerophospholipid + a triacyl-sn-glycerol"}
{"X":4280,"KEGG":"R05338","RHEA_ID":25204,"DIRECTION":"BI","MASTER_ID":25201,"metacyc":"R10-RXN","compounds":"D-ribulose 5-phosphate + formaldehyde <=> D-arabino-hex-3-ulose 6-phosphate","pmd":30.01}
{"X":4281,"KEGG":"R05339","RHEA_ID":25903,"DIRECTION":"BI","MASTER_ID":25900,"compounds":"D-arabino-hex-3-ulose 6-phosphate <=> beta-D-fructose 6-phosphate","pmd":0}
{"X":4282,"KEGG":"R05341","RHEA_ID":32222,"DIRECTION":"BI","MASTER_ID":32219,"compounds":"all-trans-lycopene <=> gamma-carotene","pmd":0}
{"X":4283,"KEGG":"R05345","RHEA_ID":55663,"DIRECTION":"BI","MASTER_ID":55660,"compounds":"2 AH2 + all-trans-beta-carotene + 2 O2 <=> 2 A + echinenone + 3 H2O","pmd":13.979}
{"X":4284,"KEGG":"R05349","RHEA_ID":12219,"DIRECTION":"BI","MASTER_ID":12216,"compounds":"9H-fluoren-9-ol + NAD(+) <=> 9H-fluoren-9-one + H(+) + NADH","pmd":484.059}
{"X":4285,"KEGG":"R05349","RHEA_ID":12219,"DIRECTION":"BI","MASTER_ID":12216,"compounds":"9H-fluoren-9-ol + NAD(+) <=> 9H-fluoren-9-one + H(+) + NADH","pmd":2.016}
{"X":4286,"KEGG":"R05350","RHEA_ID":12215,"DIRECTION":"BI","MASTER_ID":12212,"compounds":"9H-fluoren-9-ol + NADP(+) <=> 9H-fluoren-9-one + H(+) + NADPH","pmd":2.016}
{"X":4287,"KEGG":"R05350","RHEA_ID":12215,"DIRECTION":"BI","MASTER_ID":12212,"compounds":"9H-fluoren-9-ol + NADP(+) <=> 9H-fluoren-9-one + H(+) + NADPH","pmd":564.026}
{"X":4288,"KEGG":"R05352","RHEA_ID":28201,"DIRECTION":"BI","MASTER_ID":28198,"metacyc":"RXN-1302","compounds":"(S)-1-phenylethanol + NAD(+) <=> acetophenone + H(+) + NADH","pmd":544.059}
{"X":4289,"KEGG":"R05352","RHEA_ID":28201,"DIRECTION":"BI","MASTER_ID":28198,"metacyc":"RXN-1302","compounds":"(S)-1-phenylethanol + NAD(+) <=> acetophenone + H(+) + NADH","pmd":2.016}
{"X":4290,"KEGG":"R05357","RHEA_ID":17004,"DIRECTION":"BI","MASTER_ID":17001,"compounds":"amidinoproclavaminate + H2O <=> proclavaminate + urea","pmd":42.022}
{"X":4291,"KEGG":"R05360","RHEA_ID":42471,"DIRECTION":"BI","MASTER_ID":42468,"compounds":"2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O <=> 2-oxopent-4-enoate + salicylate","pmd":96.021}
{"X":4292,"KEGG":"R05361","RHEA_ID":42483,"DIRECTION":"BI","MASTER_ID":42480,"compounds":"2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O <=> (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + catechol + H(+)","pmd":92.026}
{"X":4293,"KEGG":"R05364","RHEA_ID":42579,"DIRECTION":"BI","MASTER_ID":42576,"metacyc":"RXN-668","compounds":"2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + H2O <=> 2-methylpropanoate + 2-oxopent-4-enoate + H(+)","pmd":70.042}
{"X":4294,"KEGG":"R05365","RHEA_ID":27873,"DIRECTION":"BI","MASTER_ID":27870,"compounds":"(2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O <=> (2E)-2-hydroxypenta-2,4-dienoate + anthranilate + H(+)","pmd":96.021}
{"X":4295,"KEGG":"R05369","RHEA_ID":56623,"DIRECTION":"BI","MASTER_ID":56620,"compounds":"(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + H2O <=> 2,4,5-trichlorocyclohexa-2,5-dien-1-ol + chloride + H(+)","pmd":17.966}
{"X":4296,"KEGG":"R05370","RHEA_ID":56627,"DIRECTION":"BI","MASTER_ID":56624,"compounds":"2,4,5-trichlorocyclohexa-2,5-dien-1-ol + H2O <=> 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + chloride + H(+)","pmd":17.966}
{"X":4297,"KEGG":"R05373","RHEA_ID":27669,"DIRECTION":"BI","MASTER_ID":27666,"compounds":"(R)-methylmalonyl-CoA + H(+) <=> CO2 + propanoyl-CoA","pmd":43.99}
{"X":4298,"KEGG":"R05377","RHEA_ID":42575,"DIRECTION":"BI","MASTER_ID":42572,"metacyc":"RXN-667","compounds":"3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+) <=> 2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + CO2","pmd":43.99}
{"X":4299,"KEGG":"R05378","RHEA_ID":13180,"DIRECTION":"BI","MASTER_ID":13177,"compounds":"6-phospho-5-dehydro-2-deoxy-D-gluconate <=> 3-oxopropanoate + dihydroxyacetone phosphate","pmd":88.016}
{"X":4300,"KEGG":"R05380","RHEA_ID":17888,"DIRECTION":"BI","MASTER_ID":17885,"compounds":"acetaldehyde <=> acetylene + H2O"}
{"X":4301,"KEGG":"R05383","RHEA_ID":19248,"DIRECTION":"BI","MASTER_ID":19245,"compounds":"N-phenylhydroxylamine <=> 2-aminophenol","pmd":0}
{"X":4302,"KEGG":"R05386","RHEA_ID":45483,"DIRECTION":"BI","MASTER_ID":45480,"compounds":"gamma-hexachlorocyclohexane <=> (3R,4S,5S,6R)-pentachlorocyclohexene + chloride + H(+)","pmd":35.977}
{"X":4303,"KEGG":"R05387","RHEA_ID":12155,"DIRECTION":"BI","MASTER_ID":12152,"compounds":"(3R,4S,5S,6R)-pentachlorocyclohexene <=> (3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + chloride + H(+)","pmd":35.977}
{"X":4304,"KEGG":"R05399","RHEA_ID":12431,"DIRECTION":"BI","MASTER_ID":12428,"compounds":"2-hydroxy-1,4-benzoquinone + 2 H(+) + NADH <=> benzene-1,2,4-triol + NAD(+)","pmd":2.016}
{"X":4305,"KEGG":"R05399","RHEA_ID":12431,"DIRECTION":"BI","MASTER_ID":12428,"compounds":"2-hydroxy-1,4-benzoquinone + 2 H(+) + NADH <=> benzene-1,2,4-triol + NAD(+)","pmd":539.093}
{"X":4306,"KEGG":"R05400","RHEA_ID":52891,"DIRECTION":"BI","MASTER_ID":52888,"compounds":"N-phenylhydroxylamine + NADP(+) <=> H(+) + NADPH + nitrosobenzene","pmd":636.038}
{"X":4307,"KEGG":"R05400","RHEA_ID":52891,"DIRECTION":"BI","MASTER_ID":52888,"compounds":"N-phenylhydroxylamine + NADP(+) <=> H(+) + NADPH + nitrosobenzene","pmd":2.016}
{"X":4308,"KEGG":"R05401","RHEA_ID":52895,"DIRECTION":"BI","MASTER_ID":52892,"compounds":"H2O + NADP(+) + nitrosobenzene <=> H(+) + NADPH + nitrobenzene","pmd":15.995}
{"X":4309,"KEGG":"R05401","RHEA_ID":52895,"DIRECTION":"BI","MASTER_ID":52892,"compounds":"H2O + NADP(+) + nitrosobenzene <=> H(+) + NADPH + nitrobenzene","pmd":638.054}
{"X":4310,"KEGG":"R05402","RHEA_ID":56831,"DIRECTION":"BI","MASTER_ID":56828,"compounds":"2,3,6-trichlorohydroquinone + chloride + glutathione disulfide <=> 2,3,5,6-tetrachlorohydroquinone + 2 glutathione","pmd":95.164}
{"X":4311,"KEGG":"R05402","RHEA_ID":56831,"DIRECTION":"BI","MASTER_ID":56828,"compounds":"2,3,6-trichlorohydroquinone + chloride + glutathione disulfide <=> 2,3,5,6-tetrachlorohydroquinone + 2 glutathione","pmd":33.961}
{"X":4312,"KEGG":"R05403","RHEA_ID":56835,"DIRECTION":"BI","MASTER_ID":56832,"compounds":"2,6-dichlorohydroquinone + chloride + glutathione disulfide + H(+) <=> 2,3,6-trichlorohydroquinone + 2 glutathione","pmd":129.125}
{"X":4313,"KEGG":"R05403","RHEA_ID":56835,"DIRECTION":"BI","MASTER_ID":56832,"compounds":"2,6-dichlorohydroquinone + chloride + glutathione disulfide + H(+) <=> 2,3,6-trichlorohydroquinone + 2 glutathione","pmd":33.961}
{"X":4314,"KEGG":"R05405","RHEA_ID":26308,"DIRECTION":"BI","MASTER_ID":26305,"compounds":"2-aminophenol + O2 <=> 2-aminomuconate 6-semialdehyde","pmd":31.99}
{"X":4315,"KEGG":"R05407","RHEA_ID":48575,"DIRECTION":"BI","MASTER_ID":48572,"compounds":"3,5-dichlorocatechol + O2 <=> (2E,4E)-2,4-dichloromuconate + 2 H(+)","pmd":31.99}
{"X":4316,"KEGG":"R05409","RHEA_ID":35058,"DIRECTION":"BI","MASTER_ID":35055,"metacyc":"CHLOROCATDIOXY-RXN","compounds":"3,6-dichlorocatechol + O2 <=> (2E,4E)-2,5-dichloromuconate + H(+)","pmd":31.99}
{"X":4317,"KEGG":"R05411","RHEA_ID":42467,"DIRECTION":"BI","MASTER_ID":42464,"compounds":"biphenyl-2,2',3-triol + O2 <=> 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + 2 H(+)","pmd":31.99}
{"X":4318,"KEGG":"R05413","RHEA_ID":42479,"DIRECTION":"BI","MASTER_ID":42476,"compounds":"2,2',3-trihydroxydiphenyl ether + H(+) + O2 <=> 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate","pmd":31.99}
{"X":4319,"KEGG":"R05414","RHEA_ID":27841,"DIRECTION":"BI","MASTER_ID":27838,"compounds":"9H-carbazole + H(+) + NADH + O2 <=> 2'-aminobiphenyl-2,3-diol + NAD(+)","pmd":464.046}
{"X":4320,"KEGG":"R05414","RHEA_ID":27841,"DIRECTION":"BI","MASTER_ID":27838,"compounds":"9H-carbazole + H(+) + NADH + O2 <=> 2'-aminobiphenyl-2,3-diol + NAD(+)","pmd":34.006}
{"X":4321,"KEGG":"R05419","RHEA_ID":48987,"DIRECTION":"BI","MASTER_ID":48984,"compounds":"(2,4-dichlorophenoxy)acetate + 2-oxoglutarate + O2 <=> 2,4-dichlorophenol + CO2 + glyoxylate + succinate","pmd":15.942}
{"X":4322,"KEGG":"R05419","RHEA_ID":48987,"DIRECTION":"BI","MASTER_ID":48984,"compounds":"(2,4-dichlorophenoxy)acetate + 2-oxoglutarate + O2 <=> 2,4-dichlorophenol + CO2 + glyoxylate + succinate","pmd":58.006}
{"X":4323,"KEGG":"R05420","RHEA_ID":33714,"DIRECTION":"BI","MASTER_ID":33711,"compounds":"4-sulfomuconolactone + H2O <=> 2 H(+) + maleylacetate + sulfite","pmd":63.962}
{"X":4324,"KEGG":"R05434","RHEA_ID":42463,"DIRECTION":"BI","MASTER_ID":42460,"compounds":"dibenzofuran + H(+) + NADH + O2 <=> biphenyl-2,2',3-triol + NAD(+)","pmd":463.062}
{"X":4325,"KEGG":"R05434","RHEA_ID":42463,"DIRECTION":"BI","MASTER_ID":42460,"compounds":"dibenzofuran + H(+) + NADH + O2 <=> biphenyl-2,2',3-triol + NAD(+)","pmd":34.005}
{"X":4326,"KEGG":"R05439","RHEA_ID":42475,"DIRECTION":"BI","MASTER_ID":42472,"compounds":"dibenzo-p-dioxin + NADH + O2 <=> 2,2',3-trihydroxydiphenyl ether + H(+) + NAD(+)","pmd":34.005}
{"X":4327,"KEGG":"R05439","RHEA_ID":42475,"DIRECTION":"BI","MASTER_ID":42472,"compounds":"dibenzo-p-dioxin + NADH + O2 <=> 2,2',3-trihydroxydiphenyl ether + H(+) + NAD(+)","pmd":447.067}
{"X":4328,"KEGG":"R05443","RHEA_ID":51603,"DIRECTION":"BI","MASTER_ID":51600,"compounds":"2 H(+) + m-xylene + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]","pmd":15.995}
{"X":4329,"KEGG":"R05453","RHEA_ID":28650,"DIRECTION":"BI","MASTER_ID":28647,"compounds":"acetophenone + 2 ATP + H2O + hydrogencarbonate <=> 3-oxo-3-phenylpropanoate + 2 ADP + 2 H(+) + 2 phosphate","pmd":43.99}
{"X":4330,"KEGG":"R05453","RHEA_ID":28650,"DIRECTION":"BI","MASTER_ID":28647,"compounds":"acetophenone + 2 ATP + H2O + hydrogencarbonate <=> 3-oxo-3-phenylpropanoate + 2 ADP + 2 H(+) + 2 phosphate","pmd":79.966}
{"X":4331,"KEGG":"R05459","RHEA_ID":50387,"DIRECTION":"BI","MASTER_ID":50384,"compounds":"H(+) + oxidized coenzyme F420-(gamma-Glu)(n) + tetracycline <=> 5a,11a-dehydrotetracycline + reduced coenzyme F420-(gamma-Glu)(n)","pmd":2.016}
{"X":4332,"KEGG":"R05462","RHEA_ID":50359,"DIRECTION":"BI","MASTER_ID":50356,"compounds":"4-hydroxy-6-methylpretetramide + NADPH + O2 <=> 4-dedimethylamino-4-oxo-anhydrotetracycline + H2O + NADP(+)","pmd":15.995}
{"X":4333,"KEGG":"R05462","RHEA_ID":50359,"DIRECTION":"BI","MASTER_ID":50356,"compounds":"4-hydroxy-6-methylpretetramide + NADPH + O2 <=> 4-dedimethylamino-4-oxo-anhydrotetracycline + H2O + NADP(+)","pmd":348.011}
{"X":4334,"KEGG":"R05463","RHEA_ID":50011,"DIRECTION":"BI","MASTER_ID":50008,"compounds":"6-methylpretetramide + 2 H(+) + NADPH + O2 <=> 4-hydroxy-6-methylpretetramide + H2O + NADP(+)","pmd":364.006}
{"X":4335,"KEGG":"R05463","RHEA_ID":50011,"DIRECTION":"BI","MASTER_ID":50008,"compounds":"6-methylpretetramide + 2 H(+) + NADPH + O2 <=> 4-hydroxy-6-methylpretetramide + H2O + NADP(+)","pmd":15.995}
{"X":4336,"KEGG":"R05465","RHEA_ID":10559,"DIRECTION":"BI","MASTER_ID":10556,"compounds":"D-glyceraldehyde 3-phosphate + L-arginine <=> H(+) + N(2)-(2-carboxyethyl)-L-arginine + phosphate","pmd":72.021}
{"X":4337,"KEGG":"R05465","RHEA_ID":10559,"DIRECTION":"BI","MASTER_ID":10556,"compounds":"D-glyceraldehyde 3-phosphate + L-arginine <=> H(+) + N(2)-(2-carboxyethyl)-L-arginine + phosphate","pmd":76.135}
{"X":4338,"KEGG":"R05466","RHEA_ID":20024,"DIRECTION":"BI","MASTER_ID":20021,"compounds":"2-oxoglutarate + deoxyamidinoproclavaminate + O2 <=> amidinoproclavaminate + CO2 + succinate","pmd":27.995}
{"X":4339,"KEGG":"R05466","RHEA_ID":20024,"DIRECTION":"BI","MASTER_ID":20021,"compounds":"2-oxoglutarate + deoxyamidinoproclavaminate + O2 <=> amidinoproclavaminate + CO2 + succinate","pmd":15.995}
{"X":4340,"KEGG":"R05467","RHEA_ID":23623,"DIRECTION":"BI","MASTER_ID":23620,"compounds":"ATP + N(2)-(2-carboxyethyl)-L-arginine <=> AMP + deoxyamidinoproclavaminate + diphosphate + H(+)","pmd":18.011}
{"X":4341,"KEGG":"R05467","RHEA_ID":23623,"DIRECTION":"BI","MASTER_ID":23620,"compounds":"ATP + N(2)-(2-carboxyethyl)-L-arginine <=> AMP + deoxyamidinoproclavaminate + diphosphate + H(+)","pmd":159.933}
{"X":4342,"KEGG":"R05468","RHEA_ID":12776,"DIRECTION":"BI","MASTER_ID":12773,"compounds":"2-oxoglutarate + O2 + proclavaminate <=> CO2 + dihydroclavaminate + H2O + succinate","pmd":27.995}
{"X":4343,"KEGG":"R05468","RHEA_ID":12776,"DIRECTION":"BI","MASTER_ID":12773,"compounds":"2-oxoglutarate + O2 + proclavaminate <=> CO2 + dihydroclavaminate + H2O + succinate","pmd":2.016}
{"X":4344,"KEGG":"R05468","RHEA_ID":19788,"DIRECTION":"BI","MASTER_ID":19785,"compounds":"2-oxoglutarate + dihydroclavaminate + O2 <=> clavaminate + CO2 + H2O + succinate","pmd":27.995}
{"X":4345,"KEGG":"R05468","RHEA_ID":19788,"DIRECTION":"BI","MASTER_ID":19785,"compounds":"2-oxoglutarate + dihydroclavaminate + O2 <=> clavaminate + CO2 + H2O + succinate","pmd":2.016}
{"X":4346,"KEGG":"R05470","RHEA_ID":42431,"DIRECTION":"BI","MASTER_ID":42428,"compounds":"clavaminate <=> (3R,5R)-clavulanate-9-aldehyde","pmd":1.032}
{"X":4347,"KEGG":"R05471","RHEA_ID":42071,"DIRECTION":"BI","MASTER_ID":42068,"metacyc":"RXN-8893","compounds":"(3R,5R)-clavulanate-9-aldehyde + H(+) + NADPH <=> clavulanate + NADP(+)","pmd":546.043}
{"X":4348,"KEGG":"R05471","RHEA_ID":42071,"DIRECTION":"BI","MASTER_ID":42068,"metacyc":"RXN-8893","compounds":"(3R,5R)-clavulanate-9-aldehyde + H(+) + NADPH <=> clavulanate + NADP(+)","pmd":2.016}
{"X":4349,"KEGG":"R05483","RHEA_ID":56619,"DIRECTION":"BI","MASTER_ID":56616,"compounds":"(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene <=> 1,2,4-trichlorobenzene + chloride + H(+)","pmd":35.977}
{"X":4350,"KEGG":"R05487","RHEA_ID":53395,"DIRECTION":"BI","MASTER_ID":53392,"compounds":"2-phenylacetate + O2 + reduced [NADPH--hemoprotein reductase] <=> (2-hydroxyphenyl)acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":4351,"KEGG":"R05488","RHEA_ID":31730,"DIRECTION":"BI","MASTER_ID":31727,"compounds":"FADH2 + O2 + styrene <=> (2S)-2-phenyloxirane + FAD + H(+) + H2O","pmd":2.016}
{"X":4352,"KEGG":"R05488","RHEA_ID":31730,"DIRECTION":"BI","MASTER_ID":31727,"compounds":"FADH2 + O2 + styrene <=> (2S)-2-phenyloxirane + FAD + H(+) + H2O","pmd":15.995}
{"X":4353,"KEGG":"R05507","RHEA_ID":58203,"DIRECTION":"BI","MASTER_ID":58200,"metacyc":"R562-RXN","compounds":"2-oxoglutarate + 6-aminohexanoate <=> 6-oxohexanoate + L-glutamate","pmd":1.032}
{"X":4354,"KEGG":"R05518","RHEA_ID":47975,"DIRECTION":"BI","MASTER_ID":47972,"metacyc":"RXN-16567","compounds":"dTDP-4-dehydro-6-deoxy-alpha-D-glucose <=> dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H2O","pmd":18.011}
{"X":4355,"KEGG":"R05520","RHEA_ID":32650,"DIRECTION":"BI","MASTER_ID":32647,"compounds":"erythromycin C + S-adenosyl-L-methionine <=> erythromycin A + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":4356,"KEGG":"R05522","RHEA_ID":32634,"DIRECTION":"BI","MASTER_ID":32631,"compounds":"erythromycin D + H(+) + NADPH + O2 <=> erythromycin C + H2O + NADP(+)","pmd":15.995}
{"X":4357,"KEGG":"R05522","RHEA_ID":32634,"DIRECTION":"BI","MASTER_ID":32631,"compounds":"erythromycin D + H(+) + NADPH + O2 <=> erythromycin C + H2O + NADP(+)","pmd":25.645}
{"X":4358,"KEGG":"R05526","RHEA_ID":44627,"DIRECTION":"BI","MASTER_ID":44624,"compounds":"dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + NADP(+) <=> dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H(+) + NADPH","pmd":215.021}
{"X":4359,"KEGG":"R05526","RHEA_ID":44627,"DIRECTION":"BI","MASTER_ID":44624,"compounds":"dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + NADP(+) <=> dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H(+) + NADPH","pmd":2.016}
{"X":4360,"KEGG":"R05530","RHEA_ID":41579,"DIRECTION":"BI","MASTER_ID":41576,"metacyc":"RXN-12933","compounds":"dTDP-beta-L-mycarose + erythronolide B <=> 3-O-alpha-L-mycarosylerythronolide B + dTDP + H(+)","pmd":0.239}
{"X":4361,"KEGG":"R05531","RHEA_ID":32094,"DIRECTION":"BI","MASTER_ID":32091,"compounds":"3-O-alpha-L-mycarosylerythronolide B + dTDP-alpha-D-desosamine <=> dTDP + erythromycin D + H(+)","pmd":144.318}
{"X":4362,"KEGG":"R05531","RHEA_ID":32094,"DIRECTION":"BI","MASTER_ID":32091,"compounds":"3-O-alpha-L-mycarosylerythronolide B + dTDP-alpha-D-desosamine <=> dTDP + erythromycin D + H(+)","pmd":144.317}
{"X":4363,"KEGG":"R05532","RHEA_ID":32654,"DIRECTION":"BI","MASTER_ID":32651,"compounds":"erythromycin D + S-adenosyl-L-methionine <=> erythromycin B + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":4364,"KEGG":"R05548","RHEA_ID":18056,"DIRECTION":"BI","MASTER_ID":18053,"compounds":"H2O + paraoxon <=> 4-nitrophenol + diethylphosphate + 2 H(+)","pmd":121.016}
{"X":4365,"KEGG":"R05551","RHEA_ID":34370,"DIRECTION":"BI","MASTER_ID":34367,"compounds":"acrylamide + H2O <=> acrylate + NH4(+)"}
{"X":4366,"KEGG":"R05553","RHEA_ID":16204,"DIRECTION":"BI","MASTER_ID":16201,"metacyc":"ADCLY-RXN","compounds":"4-amino-4-deoxychorismate <=> 4-aminobenzoate + H(+) + pyruvate","pmd":88.016}
{"X":4367,"KEGG":"R05554","RHEA_ID":25244,"DIRECTION":"BI","MASTER_ID":25241,"compounds":"(S)-2-ureidoglycine + H2O <=> (S)-ureidoglycolate + NH4(+)","pmd":0.984}
{"X":4368,"KEGG":"R05555","RHEA_ID":31282,"DIRECTION":"BI","MASTER_ID":31279,"compounds":"(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate <=> 2-cis,6-trans,10-trans-geranylgeranyl diphosphate + diphosphate","pmd":68.063}
{"X":4369,"KEGG":"R05555","RHEA_ID":31282,"DIRECTION":"BI","MASTER_ID":31279,"compounds":"(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate <=> 2-cis,6-trans,10-trans-geranylgeranyl diphosphate + diphosphate","pmd":204.188}
{"X":4370,"KEGG":"R05556","RHEA_ID":53011,"DIRECTION":"BI","MASTER_ID":53008,"metacyc":"RXN-11963","compounds":"(2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate <=> di-trans,poly-cis-polyprenyl diphosphate + n diphosphate"}
{"X":4371,"KEGG":"R05558","RHEA_ID":11315,"DIRECTION":"BI","MASTER_ID":11312,"compounds":"atrazine + H2O <=> chloride + H(+) + hydroxyatrazine","pmd":17.966}
{"X":4372,"KEGG":"R05559","RHEA_ID":23095,"DIRECTION":"BI","MASTER_ID":23092,"compounds":"H(+) + H2O + hydroxyatrazine <=> ethylamine + N-isopropylammelide","pmd":27.047}
{"X":4373,"KEGG":"R05560","RHEA_ID":23611,"DIRECTION":"BI","MASTER_ID":23608,"compounds":"H(+) + H2O + N-isopropylammelide <=> cyanurate + isopropylamine","pmd":41.063}
{"X":4374,"KEGG":"R05563","RHEA_ID":17528,"DIRECTION":"BI","MASTER_ID":17525,"compounds":"biuret + H2O <=> NH4(+) + urea-1-carboxylate","pmd":0.984}
{"X":4375,"KEGG":"R05566","RHEA_ID":16056,"DIRECTION":"BI","MASTER_ID":16053,"compounds":"N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UDP-N-acetyl-alpha-D-mannosamine <=> H(+) + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + UDP","pmd":203.079}
{"X":4376,"KEGG":"R05570","RHEA_ID":49251,"DIRECTION":"BI","MASTER_ID":49248,"compounds":"galactitol(out) + N(pros)-phospho-L-histidyl-[protein] <=> galactitol 1-phosphate(in) + L-histidyl-[protein]","pmd":79.966}
{"X":4377,"KEGG":"R05571","RHEA_ID":28109,"DIRECTION":"BI","MASTER_ID":28106,"ecocyc":"1.1.1.251-RXN","metacyc":"1.1.1.251-RXN","compounds":"galactitol 1-phosphate + NAD(+) <=> H(+) + keto-D-tagatose 6-phosphate + NADH","pmd":404.087}
{"X":4378,"KEGG":"R05571","RHEA_ID":28109,"DIRECTION":"BI","MASTER_ID":28106,"ecocyc":"1.1.1.251-RXN","metacyc":"1.1.1.251-RXN","compounds":"galactitol 1-phosphate + NAD(+) <=> H(+) + keto-D-tagatose 6-phosphate + NADH","pmd":2.016}
{"X":4379,"KEGG":"R05577","RHEA_ID":18352,"DIRECTION":"BI","MASTER_ID":18349,"compounds":"ATP + L-aspartate + tRNA(Asx) <=> AMP + diphosphate + L-aspartyl-tRNA(Asx)","pmd":214.026}
{"X":4380,"KEGG":"R05577","RHEA_ID":18352,"DIRECTION":"BI","MASTER_ID":18349,"compounds":"ATP + L-aspartate + tRNA(Asx) <=> AMP + diphosphate + L-aspartyl-tRNA(Asx)","pmd":159.933}
{"X":4381,"KEGG":"R05577","RHEA_ID":19652,"DIRECTION":"BI","MASTER_ID":19649,"compounds":"ATP + L-aspartate + tRNA(Asp) <=> AMP + diphosphate + L-aspartyl-tRNA(Asp)","pmd":214.026}
{"X":4382,"KEGG":"R05577","RHEA_ID":19652,"DIRECTION":"BI","MASTER_ID":19649,"compounds":"ATP + L-aspartate + tRNA(Asp) <=> AMP + diphosphate + L-aspartyl-tRNA(Asp)","pmd":159.933}
{"X":4383,"KEGG":"R05578","RHEA_ID":18400,"DIRECTION":"BI","MASTER_ID":18397,"compounds":"ATP + L-glutamate + tRNA(Glx) <=> AMP + diphosphate + L-glutamyl-tRNA(Glx)","pmd":200.01}
{"X":4384,"KEGG":"R05578","RHEA_ID":18400,"DIRECTION":"BI","MASTER_ID":18397,"compounds":"ATP + L-glutamate + tRNA(Glx) <=> AMP + diphosphate + L-glutamyl-tRNA(Glx)","pmd":159.933}
{"X":4385,"KEGG":"R05578","RHEA_ID":23543,"DIRECTION":"BI","MASTER_ID":23540,"compounds":"ATP + L-glutamate + tRNA(Glu) <=> AMP + diphosphate + L-glutamyl-tRNA(Glu)","pmd":200.01}
{"X":4386,"KEGG":"R05578","RHEA_ID":23543,"DIRECTION":"BI","MASTER_ID":23540,"compounds":"ATP + L-glutamate + tRNA(Glu) <=> AMP + diphosphate + L-glutamyl-tRNA(Glu)","pmd":159.933}
{"X":4387,"KEGG":"R05579","RHEA_ID":47423,"DIRECTION":"BI","MASTER_ID":47420,"metacyc":"RXN-12957","compounds":"A + glutaryl-CoA <=> (2E)-glutaconyl-CoA + AH2","pmd":2.016}
{"X":4388,"KEGG":"R05581","RHEA_ID":18268,"DIRECTION":"BI","MASTER_ID":18265,"metacyc":"HADTHAUERA-RXN","compounds":"6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD(+) <=> 6-oxocyclohex-1-ene-1-carbonyl-CoA + H(+) + NADH","pmd":2.016}
{"X":4389,"KEGG":"R05581","RHEA_ID":18268,"DIRECTION":"BI","MASTER_ID":18265,"metacyc":"HADTHAUERA-RXN","compounds":"6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD(+) <=> 6-oxocyclohex-1-ene-1-carbonyl-CoA + H(+) + NADH","pmd":225.035}
{"X":4390,"KEGG":"R05588","RHEA_ID":16472,"DIRECTION":"BI","MASTER_ID":16469,"metacyc":"RXN-864","compounds":"(R)-2-benzylsuccinate + succinyl-CoA <=> (R)-2-benzylsuccinyl-CoA + succinate","pmd":90.047}
{"X":4391,"KEGG":"R05594","RHEA_ID":39654,"DIRECTION":"BI","MASTER_ID":39651,"metacyc":"OAHTHAUERA-RXN","compounds":"6-oxocyclohex-1-ene-1-carbonyl-CoA + 2 H2O <=> 3-hydroxy-6-carboxyhexanoyl-CoA + H(+)","pmd":36.021}
{"X":4392,"KEGG":"R05594","RHEA_ID":40070,"DIRECTION":"BI","MASTER_ID":40067,"metacyc":"RXN-15013","compounds":"2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA + H2O <=> 3-hydroxy-6-carboxyhexanoyl-CoA + H(+)","pmd":36.021}
{"X":4393,"KEGG":"R05597","RHEA_ID":21859,"DIRECTION":"BI","MASTER_ID":21856,"metacyc":"DCHTHAUERA-RXN","compounds":"cyclohexa-1,5-diene-1-carbonyl-CoA + H2O <=> 6-hydroxycyclohex-1-ene-1-carbonyl-CoA","pmd":18.01}
{"X":4394,"KEGG":"R05598","RHEA_ID":10419,"DIRECTION":"BI","MASTER_ID":10416,"compounds":"fumarate + toluene <=> 2-benzylsuccinate","pmd":92.063}
{"X":4395,"KEGG":"R05604","RHEA_ID":17924,"DIRECTION":"BI","MASTER_ID":17921,"compounds":"D-arabinitol + NAD(+) <=> D-xylulose + H(+) + NADH","pmd":2.016}
{"X":4396,"KEGG":"R05604","RHEA_ID":17924,"DIRECTION":"BI","MASTER_ID":17921,"compounds":"D-arabinitol + NAD(+) <=> D-xylulose + H(+) + NADH","pmd":514.064}
{"X":4397,"KEGG":"R05605","RHEA_ID":17092,"DIRECTION":"BI","MASTER_ID":17089,"compounds":"2-dehydro-3-deoxy-6-phospho-D-gluconate <=> D-glyceraldehyde 3-phosphate + pyruvate","pmd":88.016}
{"X":4398,"KEGG":"R05606","RHEA_ID":20100,"DIRECTION":"BI","MASTER_ID":20097,"compounds":"D-mannonate <=> 2-dehydro-3-deoxy-D-gluconate + H2O","pmd":18.011}
{"X":4399,"KEGG":"R05608","RHEA_ID":16008,"DIRECTION":"BI","MASTER_ID":16005,"compounds":"galactarate <=> 5-dehydro-4-deoxy-D-glucarate + H2O","pmd":18.011}
{"X":4400,"KEGG":"R05612","RHEA_ID":20839,"DIRECTION":"BI","MASTER_ID":20836,"compounds":"all-trans-hexaprenyl diphosphate + isopentenyl diphosphate <=> all-trans-heptaprenyl diphosphate + diphosphate","pmd":68.063}
{"X":4401,"KEGG":"R05612","RHEA_ID":20839,"DIRECTION":"BI","MASTER_ID":20836,"compounds":"all-trans-hexaprenyl diphosphate + isopentenyl diphosphate <=> all-trans-heptaprenyl diphosphate + diphosphate","pmd":408.376}
{"X":4402,"KEGG":"R05613","RHEA_ID":22635,"DIRECTION":"BI","MASTER_ID":22632,"compounds":"(2E,6E,10E,14E)-geranylfarnesyl diphosphate + isopentenyl diphosphate <=> all-trans-hexaprenyl diphosphate + diphosphate","pmd":340.313}
{"X":4403,"KEGG":"R05613","RHEA_ID":22635,"DIRECTION":"BI","MASTER_ID":22632,"compounds":"(2E,6E,10E,14E)-geranylfarnesyl diphosphate + isopentenyl diphosphate <=> all-trans-hexaprenyl diphosphate + diphosphate","pmd":68.063}
{"X":4404,"KEGG":"R05615","RHEA_ID":27785,"DIRECTION":"BI","MASTER_ID":27782,"compounds":"4-hydroxybenzoate + all-trans-octaprenyl diphosphate <=> 4-hydroxy-3-all-trans-octaprenylbenzoate + diphosphate","pmd":544.501}
{"X":4405,"KEGG":"R05615","RHEA_ID":27785,"DIRECTION":"BI","MASTER_ID":27782,"compounds":"4-hydroxybenzoate + all-trans-octaprenyl diphosphate <=> 4-hydroxy-3-all-trans-octaprenylbenzoate + diphosphate","pmd":39.911}
{"X":4406,"KEGG":"R05616","RHEA_ID":44559,"DIRECTION":"BI","MASTER_ID":44556,"compounds":"4-hydroxybenzoate + all-trans-hexaprenyl diphosphate <=> 4-hydroxy-3-all-trans-hexaprenylbenzoate + diphosphate","pmd":39.912}
{"X":4407,"KEGG":"R05616","RHEA_ID":44559,"DIRECTION":"BI","MASTER_ID":44556,"compounds":"4-hydroxybenzoate + all-trans-hexaprenyl diphosphate <=> 4-hydroxy-3-all-trans-hexaprenylbenzoate + diphosphate","pmd":408.376}
{"X":4408,"KEGG":"R05617","RHEA_ID":26481,"DIRECTION":"BI","MASTER_ID":26478,"metacyc":"RXN-11047","compounds":"1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+) <=> a 2-demethylmenaquinol + CO2 + diphosphate"}
{"X":4409,"KEGG":"R05617","RHEA_ID":30102,"DIRECTION":"BI","MASTER_ID":30099,"compounds":"1,4-dihydroxy-2-naphthoate + all-trans-octaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-8 + CO2 + diphosphate"}
{"X":4410,"KEGG":"R05618","RHEA_ID":38014,"DIRECTION":"BI","MASTER_ID":38011,"compounds":"chlorophyll a + H2O <=> chlorophyllide a + H(+) + phytol","pmd":278.297}
{"X":4411,"KEGG":"R05621","RHEA_ID":12636,"DIRECTION":"BI","MASTER_ID":12633,"compounds":"benzoate + H(+) + NADH + O2 <=> (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+)","pmd":34.006}
{"X":4412,"KEGG":"R05621","RHEA_ID":12636,"DIRECTION":"BI","MASTER_ID":12633,"compounds":"benzoate + H(+) + NADH + O2 <=> (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+)","pmd":509.083}
{"X":4413,"KEGG":"R05623","RHEA_ID":31982,"DIRECTION":"BI","MASTER_ID":31979,"compounds":"NADPH + O2 + trimethylamine <=> H2O + NADP(+) + trimethylamine N-oxide"}
{"X":4414,"KEGG":"R05626","RHEA_ID":28125,"DIRECTION":"BI","MASTER_ID":28122,"metacyc":"UNDECAPRENOL-KINASE-RXN","compounds":"ATP + di-trans,octa-cis-undecaprenol <=> ADP + di-trans,octa-cis-undecaprenyl phosphate + H(+)","pmd":79.966}
{"X":4415,"KEGG":"R05626","RHEA_ID":23755,"DIRECTION":"BI","MASTER_ID":23752,"metacyc":"UNDECAPRENOL-KINASE-RXN","compounds":"all-trans-undecaprenol + ATP <=> ADP + all-trans-undecaprenyl phosphate + H(+)","pmd":79.966}
{"X":4416,"KEGG":"R05627","RHEA_ID":28097,"DIRECTION":"BI","MASTER_ID":28094,"compounds":"di-trans,octa-cis-undecaprenyl diphosphate + H2O <=> di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate","pmd":79.966}
{"X":4417,"KEGG":"R05629","RHEA_ID":21923,"DIRECTION":"BI","MASTER_ID":21920,"metacyc":"RXN-8975","compounds":"di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine <=> Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + UMP","pmd":522.63}
{"X":4418,"KEGG":"R05630","RHEA_ID":28389,"DIRECTION":"BI","MASTER_ID":28386,"compounds":"di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine <=> N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine-diphosphoundecaprenol + UMP","pmd":522.63}
{"X":4419,"KEGG":"R05631","RHEA_ID":22255,"DIRECTION":"BI","MASTER_ID":22252,"metacyc":"2.4.1.79-RXN","compounds":"globoside Gb3Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> globoside Gb4Cer (d18:1(4E)) + H(+) + UDP","pmd":203.079}
{"X":4420,"KEGG":"R05632","RHEA_ID":31274,"DIRECTION":"BI","MASTER_ID":31271,"compounds":"1-hydroxy-2-naphthoate + 2 H(+) + NADH + O2 <=> CO2 + H2O + NAD(+) + naphthalene-1,2-diol","pmd":27.995}
{"X":4421,"KEGG":"R05632","RHEA_ID":31274,"DIRECTION":"BI","MASTER_ID":31271,"compounds":"1-hydroxy-2-naphthoate + 2 H(+) + NADH + O2 <=> CO2 + H2O + NAD(+) + naphthalene-1,2-diol","pmd":505.072}
{"X":4422,"KEGG":"R05633","RHEA_ID":13432,"DIRECTION":"BI","MASTER_ID":13429,"ecocyc":"2.7.7.60-RXN","metacyc":"2.7.7.60-RXN","compounds":"2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) <=> 4-CDP-2-C-methyl-D-erythritol + diphosphate","pmd":305.041}
{"X":4423,"KEGG":"R05633","RHEA_ID":13432,"DIRECTION":"BI","MASTER_ID":13429,"ecocyc":"2.7.7.60-RXN","metacyc":"2.7.7.60-RXN","compounds":"2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) <=> 4-CDP-2-C-methyl-D-erythritol + diphosphate","pmd":38.097}
{"X":4424,"KEGG":"R05634","RHEA_ID":18440,"DIRECTION":"BI","MASTER_ID":18437,"compounds":"4-CDP-2-C-methyl-D-erythritol + ATP <=> 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)","pmd":79.966}
{"X":4425,"KEGG":"R05635","RHEA_ID":24423,"DIRECTION":"BI","MASTER_ID":24420,"compounds":"H2O + N-terminal N-formyl-L-methionyl-[peptide] <=> formate + N-terminal L-methionyl-[peptide]"}
{"X":4426,"KEGG":"R05636","RHEA_ID":12608,"DIRECTION":"BI","MASTER_ID":12605,"compounds":"D-glyceraldehyde 3-phosphate + H(+) + pyruvate <=> 1-deoxy-D-xylulose 5-phosphate + CO2","pmd":44.026}
{"X":4427,"KEGG":"R05637","RHEA_ID":23867,"DIRECTION":"BI","MASTER_ID":23864,"compounds":"4-CDP-2-C-methyl-D-erythritol 2-phosphate <=> 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP","pmd":277.996}
{"X":4428,"KEGG":"R05639","RHEA_ID":18564,"DIRECTION":"BI","MASTER_ID":18561,"compounds":"4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) <=> 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + H(+) + NADPH","pmd":333.728}
{"X":4429,"KEGG":"R05639","RHEA_ID":18564,"DIRECTION":"BI","MASTER_ID":18561,"compounds":"4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) <=> 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + H(+) + NADPH","pmd":2.016}
{"X":4430,"KEGG":"R05640","RHEA_ID":25289,"DIRECTION":"BI","MASTER_ID":25286,"compounds":"lanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]","pmd":16.031}
{"X":4431,"KEGG":"R05641","RHEA_ID":18504,"DIRECTION":"BI","MASTER_ID":18501,"compounds":"ergosterol + NADP(+) <=> ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+) + NADPH","pmd":349.76}
{"X":4432,"KEGG":"R05641","RHEA_ID":18504,"DIRECTION":"BI","MASTER_ID":18501,"compounds":"ergosterol + NADP(+) <=> ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+) + NADPH","pmd":2.016}
{"X":4433,"KEGG":"R05643","RHEA_ID":27301,"DIRECTION":"BI","MASTER_ID":27298,"metacyc":"RXN-11184","compounds":"2-formylbenzoate + H2O + NAD(+) <=> 2 H(+) + NADH + phthalate","pmd":15.995}
{"X":4434,"KEGG":"R05643","RHEA_ID":27301,"DIRECTION":"BI","MASTER_ID":27298,"metacyc":"RXN-11184","compounds":"2-formylbenzoate + H2O + NAD(+) <=> 2 H(+) + NADH + phthalate","pmd":498.09}
{"X":4435,"KEGG":"R05644","RHEA_ID":27468,"DIRECTION":"BI","MASTER_ID":27465,"compounds":"ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) <=> ADP-D-glycero-beta-D-manno-heptose + diphosphate","pmd":112.097}
{"X":4436,"KEGG":"R05644","RHEA_ID":27468,"DIRECTION":"BI","MASTER_ID":27465,"compounds":"ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) <=> ADP-D-glycero-beta-D-manno-heptose + diphosphate","pmd":329.053}
{"X":4437,"KEGG":"R05646","RHEA_ID":27476,"DIRECTION":"BI","MASTER_ID":27473,"compounds":"ATP + D-glycero-beta-D-manno-heptose 7-phosphate <=> ADP + D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(+)","pmd":79.966}
{"X":4438,"KEGG":"R05647","RHEA_ID":28521,"DIRECTION":"BI","MASTER_ID":28518,"compounds":"D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O <=> D-glycero-beta-D-manno-heptose 1-phosphate + phosphate","pmd":79.966}
{"X":4439,"KEGG":"R05651","RHEA_ID":24207,"DIRECTION":"BI","MASTER_ID":24204,"compounds":"acetyl phosphate + H(+) + sulfite <=> phosphate + sulfoacetaldehyde","pmd":16.005}
{"X":4440,"KEGG":"R05652","RHEA_ID":10423,"DIRECTION":"BI","MASTER_ID":10420,"metacyc":"TAURINE-AMINOTRANSFERASE-RXN","compounds":"pyruvate + taurine <=> L-alanine + sulfoacetaldehyde","pmd":1.032}
{"X":4441,"KEGG":"R05661","RHEA_ID":13500,"DIRECTION":"BI","MASTER_ID":13497,"compounds":"5-dehydro-2-deoxy-D-gluconate + ATP <=> 6-phospho-5-dehydro-2-deoxy-D-gluconate + ADP + H(+)","pmd":79.966}
{"X":4442,"KEGG":"R05662","RHEA_ID":23195,"DIRECTION":"BI","MASTER_ID":23192,"compounds":"Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + UDP-N-acetyl-alpha-D-glucosamine <=> beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + H(+) + UDP","pmd":203.079}
{"X":4443,"KEGG":"R05666","RHEA_ID":41383,"DIRECTION":"BI","MASTER_ID":41380,"compounds":"H(+) + NADH + O2 + toluene <=> 4-methylphenol + H2O + NAD(+)","pmd":557.067}
{"X":4444,"KEGG":"R05678","RHEA_ID":24487,"DIRECTION":"BI","MASTER_ID":24484,"compounds":"NAD(+) + sulcatol <=> H(+) + NADH + sulcatone","pmd":538.012}
{"X":4445,"KEGG":"R05678","RHEA_ID":24487,"DIRECTION":"BI","MASTER_ID":24484,"compounds":"NAD(+) + sulcatol <=> H(+) + NADH + sulcatone","pmd":2.016}
{"X":4446,"KEGG":"R05679","RHEA_ID":21415,"DIRECTION":"BI","MASTER_ID":21412,"compounds":"NAD(+) + sn-glycerol 1-phosphate <=> dihydroxyacetone phosphate + H(+) + NADH","pmd":494.119}
{"X":4447,"KEGG":"R05679","RHEA_ID":21415,"DIRECTION":"BI","MASTER_ID":21412,"compounds":"NAD(+) + sn-glycerol 1-phosphate <=> dihydroxyacetone phosphate + H(+) + NADH","pmd":2.016}
{"X":4448,"KEGG":"R05680","RHEA_ID":21419,"DIRECTION":"BI","MASTER_ID":21416,"compounds":"NADP(+) + sn-glycerol 1-phosphate <=> dihydroxyacetone phosphate + H(+) + NADPH","pmd":2.016}
{"X":4449,"KEGG":"R05680","RHEA_ID":21419,"DIRECTION":"BI","MASTER_ID":21416,"compounds":"NADP(+) + sn-glycerol 1-phosphate <=> dihydroxyacetone phosphate + H(+) + NADPH","pmd":574.085}
{"X":4450,"KEGG":"R05681","RHEA_ID":14456,"DIRECTION":"BI","MASTER_ID":14453,"compounds":"4-(phosphooxy)-L-threonine + NAD(+) <=> (2S)-2-amino-3-oxo-4-(phosphooxy)butanoate + H(+) + NADH","pmd":2.016}
{"X":4451,"KEGG":"R05681","RHEA_ID":14456,"DIRECTION":"BI","MASTER_ID":14453,"compounds":"4-(phosphooxy)-L-threonine + NAD(+) <=> (2S)-2-amino-3-oxo-4-(phosphooxy)butanoate + H(+) + NADH","pmd":451.113}
{"X":4452,"KEGG":"R05682","RHEA_ID":20668,"DIRECTION":"BI","MASTER_ID":20665,"compounds":"1,5-anhydro-D-glucitol + NADP(+) <=> 1,5-anhydro-D-fructose + H(+) + NADPH","pmd":2.016}
{"X":4453,"KEGG":"R05682","RHEA_ID":20668,"DIRECTION":"BI","MASTER_ID":20665,"compounds":"1,5-anhydro-D-glucitol + NADP(+) <=> 1,5-anhydro-D-fructose + H(+) + NADPH","pmd":582.031}
{"X":4454,"KEGG":"R05683","RHEA_ID":21175,"DIRECTION":"BI","MASTER_ID":21172,"compounds":"L-idonate + NAD(+) <=> 5-dehydro-D-gluconate + H(+) + NADH","pmd":470.074}
{"X":4455,"KEGG":"R05683","RHEA_ID":21175,"DIRECTION":"BI","MASTER_ID":21172,"compounds":"L-idonate + NAD(+) <=> 5-dehydro-D-gluconate + H(+) + NADH","pmd":2.016}
{"X":4456,"KEGG":"R05684","RHEA_ID":21179,"DIRECTION":"BI","MASTER_ID":21176,"compounds":"L-idonate + NADP(+) <=> 5-dehydro-D-gluconate + H(+) + NADPH","pmd":550.041}
{"X":4457,"KEGG":"R05684","RHEA_ID":21179,"DIRECTION":"BI","MASTER_ID":21176,"compounds":"L-idonate + NADP(+) <=> 5-dehydro-D-gluconate + H(+) + NADPH","pmd":2.016}
{"X":4458,"KEGG":"R05685","RHEA_ID":18532,"DIRECTION":"BI","MASTER_ID":18529,"compounds":"3-methylbutanol + NAD(+) <=> 3-methylbutanal + H(+) + NADH"}
{"X":4459,"KEGG":"R05686","RHEA_ID":18528,"DIRECTION":"BI","MASTER_ID":18525,"compounds":"3-methylbutanol + NADP(+) <=> 3-methylbutanal + H(+) + NADPH"}
{"X":4460,"KEGG":"R05687","RHEA_ID":36582,"DIRECTION":"BI","MASTER_ID":36579,"compounds":"dTDP-alpha-D-fucose + NAD(+) <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH","pmd":2.016}
{"X":4461,"KEGG":"R05687","RHEA_ID":36582,"DIRECTION":"BI","MASTER_ID":36579,"compounds":"dTDP-alpha-D-fucose + NAD(+) <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH","pmd":198.018}
{"X":4462,"KEGG":"R05687","RHEA_ID":36586,"DIRECTION":"BI","MASTER_ID":36583,"compounds":"dTDP-alpha-D-fucose + NADP(+) <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH","pmd":2.016}
{"X":4463,"KEGG":"R05687","RHEA_ID":36586,"DIRECTION":"BI","MASTER_ID":36583,"compounds":"dTDP-alpha-D-fucose + NADP(+) <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH","pmd":198.018}
{"X":4464,"KEGG":"R05688","RHEA_ID":13720,"DIRECTION":"BI","MASTER_ID":13717,"ecocyc":"DXPREDISOM-RXN","metacyc":"DXPREDISOM-RXN","compounds":"2-C-methyl-D-erythritol 4-phosphate + NADP(+) <=> 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH","pmd":530.059}
{"X":4465,"KEGG":"R05688","RHEA_ID":13720,"DIRECTION":"BI","MASTER_ID":13717,"ecocyc":"DXPREDISOM-RXN","metacyc":"DXPREDISOM-RXN","compounds":"2-C-methyl-D-erythritol 4-phosphate + NADP(+) <=> 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH","pmd":2.016}
{"X":4466,"KEGG":"R05689","RHEA_ID":13252,"DIRECTION":"BI","MASTER_ID":13249,"compounds":"(R)-2-hydroxypropyl-coenzyme M + NAD(+) <=> 2-oxopropyl-coenzyme M + H(+) + NADH","pmd":2.016}
{"X":4467,"KEGG":"R05689","RHEA_ID":13252,"DIRECTION":"BI","MASTER_ID":13249,"compounds":"(R)-2-hydroxypropyl-coenzyme M + NAD(+) <=> 2-oxopropyl-coenzyme M + H(+) + NADH","pmd":466.115}
{"X":4468,"KEGG":"R05690","RHEA_ID":21055,"DIRECTION":"BI","MASTER_ID":21052,"compounds":"(2S)-2-hydroxypropyl-coenzyme M + NAD(+) <=> 2-oxopropyl-coenzyme M + H(+) + NADH","pmd":2.016}
{"X":4469,"KEGG":"R05690","RHEA_ID":21055,"DIRECTION":"BI","MASTER_ID":21052,"compounds":"(2S)-2-hydroxypropyl-coenzyme M + NAD(+) <=> 2-oxopropyl-coenzyme M + H(+) + NADH","pmd":466.115}
{"X":4470,"KEGG":"R05691","RHEA_ID":18412,"DIRECTION":"BI","MASTER_ID":18409,"metacyc":"1.1.1.270-RXN","compounds":"4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) <=> 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH","pmd":345.728}
{"X":4471,"KEGG":"R05691","RHEA_ID":18412,"DIRECTION":"BI","MASTER_ID":18409,"metacyc":"1.1.1.270-RXN","compounds":"4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) <=> 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH","pmd":2.016}
{"X":4472,"KEGG":"R05692","RHEA_ID":18888,"DIRECTION":"BI","MASTER_ID":18885,"compounds":"GDP-beta-L-fucose + NADP(+) <=> GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH","pmd":2.016}
{"X":4473,"KEGG":"R05692","RHEA_ID":18888,"DIRECTION":"BI","MASTER_ID":18885,"compounds":"GDP-beta-L-fucose + NADP(+) <=> GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH","pmd":157.017}
{"X":4474,"KEGG":"R05693","RHEA_ID":28197,"DIRECTION":"BI","MASTER_ID":28194,"metacyc":"RXN-11689","compounds":"(S)-3-sulfolactate + NAD(+) <=> 3-sulfopyruvate + H(+) + NADH","pmd":2.016}
{"X":4475,"KEGG":"R05693","RHEA_ID":28197,"DIRECTION":"BI","MASTER_ID":28194,"metacyc":"RXN-11689","compounds":"(S)-3-sulfolactate + NAD(+) <=> 3-sulfopyruvate + H(+) + NADH","pmd":496.144}
{"X":4476,"KEGG":"R05695","RHEA_ID":15492,"DIRECTION":"BI","MASTER_ID":15489,"compounds":"adenosine + H2O + 2 O2 <=> 9-riburonosyladenine + H(+) + 2 H2O2","pmd":13.979}
{"X":4477,"KEGG":"R05696","RHEA_ID":18188,"DIRECTION":"BI","MASTER_ID":18185,"compounds":"adenosine + O2 <=> 5'-dehydroadenosine + H2O2","pmd":2.016}
{"X":4478,"KEGG":"R05697","RHEA_ID":22543,"DIRECTION":"BI","MASTER_ID":22540,"compounds":"5'-dehydroadenosine + H2O + O2 <=> 9-riburonosyladenine + H(+) + H2O2","pmd":15.995}
{"X":4479,"KEGG":"R05698","RHEA_ID":18516,"DIRECTION":"BI","MASTER_ID":18513,"compounds":"D-mannitol + O2 <=> D-mannose + H2O2","pmd":2.016}
{"X":4480,"KEGG":"R05699","RHEA_ID":13312,"DIRECTION":"BI","MASTER_ID":13309,"compounds":"H2O + NAD(+) + vanillin <=> 4-hydroxy-3-methoxybenzoate + 2 H(+) + NADH","pmd":15.995}
{"X":4481,"KEGG":"R05699","RHEA_ID":13312,"DIRECTION":"BI","MASTER_ID":13309,"compounds":"H2O + NAD(+) + vanillin <=> 4-hydroxy-3-methoxybenzoate + 2 H(+) + NADH","pmd":496.075}
{"X":4482,"KEGG":"R05700","RHEA_ID":23971,"DIRECTION":"BI","MASTER_ID":23968,"compounds":"(E)-coniferaldehyde + H2O + NAD(+) <=> 2 H(+) + NADH + trans-ferulate","pmd":15.995}
{"X":4483,"KEGG":"R05700","RHEA_ID":23971,"DIRECTION":"BI","MASTER_ID":23968,"compounds":"(E)-coniferaldehyde + H2O + NAD(+) <=> 2 H(+) + NADH + trans-ferulate","pmd":470.059}
{"X":4484,"KEGG":"R05701","RHEA_ID":23967,"DIRECTION":"BI","MASTER_ID":23964,"compounds":"(E)-coniferaldehyde + H2O + NADP(+) <=> 2 H(+) + NADPH + trans-ferulate","pmd":550.025}
{"X":4485,"KEGG":"R05701","RHEA_ID":23967,"DIRECTION":"BI","MASTER_ID":23964,"compounds":"(E)-coniferaldehyde + H2O + NADP(+) <=> 2 H(+) + NADPH + trans-ferulate","pmd":15.995}
{"X":4486,"KEGG":"R05702","RHEA_ID":12760,"DIRECTION":"BI","MASTER_ID":12757,"compounds":"dihydrozeatin + NADP(+) <=> H(+) + NADPH + zeatin","pmd":524.971}
{"X":4487,"KEGG":"R05702","RHEA_ID":12760,"DIRECTION":"BI","MASTER_ID":12757,"compounds":"dihydrozeatin + NADP(+) <=> H(+) + NADPH + zeatin","pmd":2.016}
{"X":4488,"KEGG":"R05703","RHEA_ID":13688,"DIRECTION":"BI","MASTER_ID":13685,"compounds":"5alpha-cholest-7-en-3beta-ol + NADP(+) <=> 5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH","pmd":2.016}
{"X":4489,"KEGG":"R05703","RHEA_ID":13688,"DIRECTION":"BI","MASTER_ID":13685,"compounds":"5alpha-cholest-7-en-3beta-ol + NADP(+) <=> 5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH","pmd":359.744}
{"X":4490,"KEGG":"R05704","RHEA_ID":15824,"DIRECTION":"BI","MASTER_ID":15821,"metacyc":"1.4.99.5-RXN","compounds":"2 A + glycine <=> 2 AH2 + CO2 + hydrogen cyanide"}
{"X":4491,"KEGG":"R05705","RHEA_ID":21623,"DIRECTION":"BI","MASTER_ID":21620,"metacyc":"RXN-9510","compounds":"FMNH2 + NAD(+) <=> FMN + 2 H(+) + NADH","pmd":208.012}
{"X":4492,"KEGG":"R05705","RHEA_ID":21623,"DIRECTION":"BI","MASTER_ID":21620,"metacyc":"RXN-9510","compounds":"FMNH2 + NAD(+) <=> FMN + 2 H(+) + NADH","pmd":2.016}
{"X":4493,"KEGG":"R05706","RHEA_ID":21627,"DIRECTION":"BI","MASTER_ID":21624,"compounds":"FMNH2 + NADP(+) <=> FMN + 2 H(+) + NADPH","pmd":2.016}
{"X":4494,"KEGG":"R05706","RHEA_ID":21627,"DIRECTION":"BI","MASTER_ID":21624,"compounds":"FMNH2 + NADP(+) <=> FMN + 2 H(+) + NADPH","pmd":287.979}
{"X":4495,"KEGG":"R05707","RHEA_ID":19380,"DIRECTION":"BI","MASTER_ID":19377,"compounds":"NADP(+) + reduced riboflavin <=> 2 H(+) + NADPH + riboflavin","pmd":2.016}
{"X":4496,"KEGG":"R05707","RHEA_ID":19380,"DIRECTION":"BI","MASTER_ID":19377,"compounds":"NADP(+) + reduced riboflavin <=> 2 H(+) + NADPH + riboflavin","pmd":367.945}
{"X":4497,"KEGG":"R05708","RHEA_ID":13628,"DIRECTION":"BI","MASTER_ID":13625,"metacyc":"1.5.99.12-RXN","compounds":"A + H2O + N(6)-dimethylallyladenine <=> 3-methyl-2-butenal + adenine + AH2","pmd":68.063}
{"X":4498,"KEGG":"R05711","RHEA_ID":16272,"DIRECTION":"BI","MASTER_ID":16269,"metacyc":"AZOBENZENE-REDUCTASE-RXN","compounds":"aniline + N,N-dimethyl-1,4-phenylenediamine + 2 NADP(+) <=> 4-(dimethylamino)azobenzene + 2 H(+) + 2 NADPH","pmd":518.957}
{"X":4499,"KEGG":"R05711","RHEA_ID":16272,"DIRECTION":"BI","MASTER_ID":16269,"metacyc":"AZOBENZENE-REDUCTASE-RXN","compounds":"aniline + N,N-dimethyl-1,4-phenylenediamine + 2 NADP(+) <=> 4-(dimethylamino)azobenzene + 2 H(+) + 2 NADPH","pmd":89.027}
{"X":4500,"KEGG":"R05712","RHEA_ID":13092,"DIRECTION":"BI","MASTER_ID":13089,"compounds":"6 [Fe(III)cytochrome c] + 2 H2O + NH4(+) <=> 6 [Fe(II)cytochrome c] + 8 H(+) + nitrite"}
{"X":4501,"KEGG":"R05713","RHEA_ID":16980,"DIRECTION":"BI","MASTER_ID":16977,"compounds":"acetoacetate + coenzyme M + NADP(+) <=> 2-oxopropyl-coenzyme M + CO2 + NADPH","pmd":56.026}
{"X":4502,"KEGG":"R05713","RHEA_ID":16980,"DIRECTION":"BI","MASTER_ID":16977,"compounds":"acetoacetate + coenzyme M + NADP(+) <=> 2-oxopropyl-coenzyme M + CO2 + NADPH","pmd":546.081}
{"X":4503,"KEGG":"R05713","RHEA_ID":16980,"DIRECTION":"BI","MASTER_ID":16977,"compounds":"acetoacetate + coenzyme M + NADP(+) <=> 2-oxopropyl-coenzyme M + CO2 + NADPH","pmd":95.97}
{"X":4504,"KEGG":"R05714","RHEA_ID":14620,"DIRECTION":"BI","MASTER_ID":14617,"compounds":"CoA + glutathione + NADP(+) <=> CoA-glutathione + H(+) + NADPH","pmd":438.007}
{"X":4505,"KEGG":"R05714","RHEA_ID":14620,"DIRECTION":"BI","MASTER_ID":14617,"compounds":"CoA + glutathione + NADP(+) <=> CoA-glutathione + H(+) + NADPH","pmd":22.024}
{"X":4506,"KEGG":"R05715","RHEA_ID":12692,"DIRECTION":"BI","MASTER_ID":12689,"compounds":"2 mycothiol + NAD(+) <=> H(+) + mycothione + NADH","pmd":306.171}
{"X":4507,"KEGG":"R05715","RHEA_ID":12692,"DIRECTION":"BI","MASTER_ID":12689,"compounds":"2 mycothiol + NAD(+) <=> H(+) + mycothione + NADH","pmd":178.973}
{"X":4508,"KEGG":"R05716","RHEA_ID":12688,"DIRECTION":"BI","MASTER_ID":12685,"compounds":"2 mycothiol + NADP(+) <=> H(+) + mycothione + NADPH","pmd":258.939}
{"X":4509,"KEGG":"R05716","RHEA_ID":12688,"DIRECTION":"BI","MASTER_ID":12685,"compounds":"2 mycothiol + NADP(+) <=> H(+) + mycothione + NADPH","pmd":226.205}
{"X":4510,"KEGG":"R05717","RHEA_ID":14144,"DIRECTION":"BI","MASTER_ID":14141,"compounds":"AMP + glutathione disulfide + 2 H(+) + sulfite <=> adenosine 5'-phosphosulfate + 2 glutathione","pmd":185.132}
{"X":4511,"KEGG":"R05717","RHEA_ID":14144,"DIRECTION":"BI","MASTER_ID":14141,"compounds":"AMP + glutathione disulfide + 2 H(+) + sulfite <=> adenosine 5'-phosphosulfate + 2 glutathione","pmd":39.979}
{"X":4512,"KEGG":"R05718","RHEA_ID":18996,"DIRECTION":"BI","MASTER_ID":18993,"compounds":"(9Z,12Z)-octadecadienoate + O2 <=> (11S)-hydroperoxy-(9Z,12Z)-octadecadienoate","pmd":31.99}
{"X":4513,"KEGG":"R05719","RHEA_ID":17952,"DIRECTION":"BI","MASTER_ID":17949,"compounds":"3-hydroxy-1H-quinolin-4-one + O2 <=> CO + H(+) + N-formylanthranilate","pmd":3.995}
{"X":4514,"KEGG":"R05720","RHEA_ID":21575,"DIRECTION":"BI","MASTER_ID":21572,"compounds":"3-hydroxy-2-methyl-1H-quinolin-4-one + O2 <=> CO + H(+) + N-acetylanthranilate","pmd":3.995}
{"X":4515,"KEGG":"R05721","RHEA_ID":21407,"DIRECTION":"BI","MASTER_ID":21404,"metacyc":"1.13.11.49-RXN","compounds":"chloride + O2 <=> chlorite"}
{"X":4516,"KEGG":"R05722","RHEA_ID":16068,"DIRECTION":"BI","MASTER_ID":16065,"compounds":"2-oxoglutarate + O2 + phytanoyl-CoA <=> 2-hydroxyphytanoyl-CoA + CO2 + succinate","pmd":27.995}
{"X":4517,"KEGG":"R05723","RHEA_ID":10767,"DIRECTION":"BI","MASTER_ID":10764,"compounds":"(2R,3S,4S)-leucocyanidin + 2-oxoglutarate + O2 <=> (4S)-2,3-dehydroleucocyanidin + CO2 + H(+) + H2O + succinate","pmd":2.016}
{"X":4518,"KEGG":"R05723","RHEA_ID":10767,"DIRECTION":"BI","MASTER_ID":10764,"compounds":"(2R,3S,4S)-leucocyanidin + 2-oxoglutarate + O2 <=> (4S)-2,3-dehydroleucocyanidin + CO2 + H(+) + H2O + succinate","pmd":27.995}
{"X":4519,"KEGG":"R05724","RHEA_ID":19472,"DIRECTION":"BI","MASTER_ID":19469,"compounds":"NADH + 2 nitric oxide + 2 O2 <=> H(+) + NAD(+) + 2 nitrate"}
{"X":4520,"KEGG":"R05725","RHEA_ID":19468,"DIRECTION":"BI","MASTER_ID":19465,"compounds":"NADPH + 2 nitric oxide + 2 O2 <=> H(+) + NADP(+) + 2 nitrate"}
{"X":4521,"KEGG":"R05727","RHEA_ID":20152,"DIRECTION":"BI","MASTER_ID":20149,"compounds":"O2 + quinine + reduced [NADPH--hemoprotein reductase] <=> 3-hydroxyquinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":4522,"KEGG":"R05728","RHEA_ID":18404,"DIRECTION":"BI","MASTER_ID":18401,"compounds":"(E)-4-hydroxyphenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-4-hydroxymandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]","pmd":2.016}
{"X":4523,"KEGG":"R05731","RHEA_ID":14920,"DIRECTION":"BI","MASTER_ID":14917,"compounds":"3 O2 + obtusifoliol + 3 reduced [NADPH--hemoprotein reductase] <=> 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]","pmd":16.031}
{"X":4524,"KEGG":"R05732","RHEA_ID":16652,"DIRECTION":"BI","MASTER_ID":16649,"compounds":"(S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-3'-hydroxy-N-methylcoclaurine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":4525,"KEGG":"R05733","RHEA_ID":55231,"DIRECTION":"BI","MASTER_ID":55228,"compounds":"4beta-hydroxymethyl-4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 [Fe(III)-cytochrome b5] + 2 H2O","pmd":2.016}
{"X":4526,"KEGG":"R05734","RHEA_ID":55235,"DIRECTION":"BI","MASTER_ID":55232,"compounds":"3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 [Fe(II)-cytochrome b5] + H(+) + O2 <=> 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate + 2 [Fe(III)-cytochrome b561] + H2O","pmd":15.995}
{"X":4527,"KEGG":"R05735","RHEA_ID":18388,"DIRECTION":"BI","MASTER_ID":18385,"compounds":"acetone + ATP + CO2 + 2 H2O <=> acetoacetate + AMP + 3 H(+) + 2 phosphate","pmd":159.933}
{"X":4528,"KEGG":"R05739","RHEA_ID":17772,"DIRECTION":"BI","MASTER_ID":17769,"compounds":"choline + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> betaine aldehyde hydrate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]","pmd":15.995}
{"X":4529,"KEGG":"R05740","RHEA_ID":23459,"DIRECTION":"BI","MASTER_ID":23456,"compounds":"(9Z,12Z)-octadecadienoate + AH2 + O2 <=> A + crepenynate + 2 H2O","pmd":2.016}
{"X":4530,"KEGG":"R05742","RHEA_ID":18932,"DIRECTION":"BI","MASTER_ID":18929,"compounds":"AH2 + O2 + thiophene-2-carbonyl-CoA <=> 5-hydroxythiophene-2-carbonyl-CoA + A + H(+) + H2O","pmd":15.995}
{"X":4531,"KEGG":"R05743","RHEA_ID":21327,"DIRECTION":"BI","MASTER_ID":21324,"metacyc":"1.15.1.2-RXN","compounds":"2 H(+) + reduced [rubredoxin] + superoxide <=> H2O2 + oxidized [rubredoxin]"}
{"X":4532,"KEGG":"R05745","RHEA_ID":17900,"DIRECTION":"BI","MASTER_ID":17897,"compounds":"A + ethylbenzene + H2O <=> (S)-1-phenylethanol + AH2","pmd":15.995}
{"X":4533,"KEGG":"R05746","RHEA_ID":13176,"DIRECTION":"BI","MASTER_ID":13173,"compounds":"H2O + NAD(+) + phosphonate <=> H(+) + NADH + phosphate"}
{"X":4534,"KEGG":"R05747","RHEA_ID":22019,"DIRECTION":"BI","MASTER_ID":22016,"ecocyc":"RXN-982","metacyc":"RXN-982","compounds":"[glutaredoxin]-dithiol + arsenate + H(+) <=> [glutaredoxin]-disulfide + arsenite + H2O"}
{"X":4535,"KEGG":"R05748","RHEA_ID":15972,"DIRECTION":"BI","MASTER_ID":15969,"compounds":"2 glutathione + H(+) + methylarsonate <=> glutathione disulfide + H2O + methylarsonous acid","pmd":183.133}
{"X":4536,"KEGG":"R05748","RHEA_ID":15972,"DIRECTION":"BI","MASTER_ID":15969,"compounds":"2 glutathione + H(+) + methylarsonate <=> glutathione disulfide + H2O + methylarsonous acid","pmd":15.995}
{"X":4537,"KEGG":"R05749","RHEA_ID":12299,"DIRECTION":"BI","MASTER_ID":12296,"compounds":"deacetylipecoside + H2O <=> dopamine + secologanin","pmd":135.069}
{"X":4538,"KEGG":"R05749","RHEA_ID":12299,"DIRECTION":"BI","MASTER_ID":12296,"compounds":"deacetylipecoside + H2O <=> dopamine + secologanin","pmd":370.126}
{"X":4539,"KEGG":"R05750","RHEA_ID":21759,"DIRECTION":"BI","MASTER_ID":21756,"compounds":"deacetylisoipecoside + H2O <=> dopamine + secologanin","pmd":370.126}
{"X":4540,"KEGG":"R05750","RHEA_ID":21759,"DIRECTION":"BI","MASTER_ID":21756,"compounds":"deacetylisoipecoside + H2O <=> dopamine + secologanin","pmd":135.069}
{"X":4541,"KEGG":"R05751","RHEA_ID":18704,"DIRECTION":"BI","MASTER_ID":18701,"compounds":"arsenite + H2O + 2 oxidized [azurin] <=> arsenate + 3 H(+) + 2 reduced [azurin]"}
{"X":4542,"KEGG":"R05752","RHEA_ID":18452,"DIRECTION":"BI","MASTER_ID":18449,"metacyc":"1.20.99.1-RXN","compounds":"A + arsenite + H2O <=> AH2 + arsenate + H(+)"}
{"X":4543,"KEGG":"R05753","RHEA_ID":20356,"DIRECTION":"BI","MASTER_ID":20353,"compounds":"A + chloride + H(+) + trichloroethene <=> AH2 + tetrachloroethene","pmd":33.961}
{"X":4544,"KEGG":"R05754","RHEA_ID":18912,"DIRECTION":"BI","MASTER_ID":18909,"compounds":"2,4,6-trichlorophenol + S-adenosyl-L-methionine <=> 2,4,6-trichloroanisole + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":4545,"KEGG":"R05755","RHEA_ID":15296,"DIRECTION":"BI","MASTER_ID":15293,"compounds":"arsenite + S-adenosyl-L-methionine <=> H(+) + methylarsonate + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":4546,"KEGG":"R05756","RHEA_ID":11687,"DIRECTION":"BI","MASTER_ID":11684,"compounds":"methylarsonous acid + S-adenosyl-L-methionine <=> dimethylarsinate + 2 H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":4547,"KEGG":"R05757","RHEA_ID":11699,"DIRECTION":"BI","MASTER_ID":11696,"compounds":"3'-demethylstaurosporine + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + staurosporine","pmd":14.016}
{"X":4548,"KEGG":"R05758","RHEA_ID":12427,"DIRECTION":"BI","MASTER_ID":12424,"metacyc":"4.3.1.16-RXN","compounds":"(3S)-3-hydroxy-L-aspartate <=> NH4(+) + oxaloacetate","pmd":17.026}
{"X":4549,"KEGG":"R05759","RHEA_ID":13352,"DIRECTION":"BI","MASTER_ID":13349,"compounds":"jasmonate + S-adenosyl-L-methionine <=> methyl (-)-jasmonate + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":4550,"KEGG":"R05760","RHEA_ID":13140,"DIRECTION":"BI","MASTER_ID":13137,"compounds":"cycloartenol + S-adenosyl-L-methionine <=> cyclolaudenol + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":4551,"KEGG":"R05761","RHEA_ID":19424,"DIRECTION":"BI","MASTER_ID":19421,"compounds":"(R)-2-hydroxypropyl-coenzyme M <=> (R)-1,2-epoxypropane + coenzyme M","pmd":58.042}
{"X":4552,"KEGG":"R05762","RHEA_ID":20907,"DIRECTION":"BI","MASTER_ID":20904,"compounds":"(2S)-2-hydroxypropyl-coenzyme M <=> (S)-1,2-epoxypropane + coenzyme M","pmd":58.042}
{"X":4553,"KEGG":"R05763","RHEA_ID":14972,"DIRECTION":"BI","MASTER_ID":14969,"compounds":"S-adenosyl-L-methionine + trans-aconitate <=> (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":4554,"KEGG":"R05764","RHEA_ID":22203,"DIRECTION":"BI","MASTER_ID":22200,"compounds":"S-adenosyl-L-methionine + trans-aconitate <=> (E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":4555,"KEGG":"R05765","RHEA_ID":25665,"DIRECTION":"BI","MASTER_ID":25662,"compounds":"(2E)-geranyl diphosphate <=> alpha-pinene + diphosphate","pmd":177.943}
{"X":4556,"KEGG":"R05765","RHEA_ID":25491,"DIRECTION":"BI","MASTER_ID":25488,"compounds":"(2E)-geranyl diphosphate <=> (1S,5S)-alpha-pinene + diphosphate","pmd":177.943}
{"X":4557,"KEGG":"R05766","RHEA_ID":25669,"DIRECTION":"BI","MASTER_ID":25666,"compounds":"(2E)-geranyl diphosphate <=> beta-pinene + diphosphate","pmd":177.943}
{"X":4558,"KEGG":"R05766","RHEA_ID":25499,"DIRECTION":"BI","MASTER_ID":25496,"compounds":"(2E)-geranyl diphosphate <=> (1S,5S)-beta-pinene + diphosphate","pmd":177.943}
{"X":4559,"KEGG":"R05767","RHEA_ID":20867,"DIRECTION":"BI","MASTER_ID":20864,"metacyc":"2.4.1.216-RXN","compounds":"alpha,alpha-trehalose 6-phosphate + phosphate <=> beta-D-glucose 1-phosphate + D-glucose 6-phosphate","pmd":162.053}
{"X":4560,"KEGG":"R05768","RHEA_ID":13540,"DIRECTION":"BI","MASTER_ID":13537,"compounds":"(2R)-3-phosphoglycerate + GDP-alpha-D-mannose <=> 2-O-(alpha-D-mannosyl)-3-phosphoglycerate + GDP + H(+)","pmd":162.053}
{"X":4561,"KEGG":"R05769","RHEA_ID":12563,"DIRECTION":"BI","MASTER_ID":12560,"metacyc":"2.4.1.218-RXN","compounds":"hydroquinone + UDP-alpha-D-glucose <=> H(+) + hydroquinone O-beta-D-glucopyranoside + UDP","pmd":162.053}
{"X":4562,"KEGG":"R05771","RHEA_ID":18200,"DIRECTION":"BI","MASTER_ID":18197,"metacyc":"4.2.1.103-RXN","compounds":"H(+) + N-cyclohexylformamide <=> cyclohexyl isocyanide + H2O","pmd":18.011}
{"X":4563,"KEGG":"R05772","RHEA_ID":14520,"DIRECTION":"BI","MASTER_ID":14517,"compounds":"3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA <=> feruloyl-CoA + H2O","pmd":18.01}
{"X":4564,"KEGG":"R05773","RHEA_ID":18728,"DIRECTION":"BI","MASTER_ID":18725,"compounds":"3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA <=> acetyl-CoA + vanillin","pmd":152.047}
{"X":4565,"KEGG":"R05774","RHEA_ID":20951,"DIRECTION":"BI","MASTER_ID":20948,"compounds":"3-sulfopyruvate + H(+) <=> CO2 + sulfoacetaldehyde","pmd":43.99}
{"X":4566,"KEGG":"R05775","RHEA_ID":13200,"DIRECTION":"BI","MASTER_ID":13197,"metacyc":"RXN-1223","compounds":"H(+) + sulfite + UDP-alpha-D-glucose <=> H2O + UDP-alpha-D-6-sulfoquinovose","pmd":63.962}
{"X":4567,"KEGG":"R05776","RHEA_ID":21047,"DIRECTION":"BI","MASTER_ID":21044,"compounds":"24-methylidenelophenol + S-adenosyl-L-methionine <=> (Z)-24-ethylidenelophenol + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":4568,"KEGG":"R05778","RHEA_ID":21379,"DIRECTION":"BI","MASTER_ID":21376,"metacyc":"1.13.11.46-RXN","compounds":"3-(4-hydroxyphenyl)pyruvate + O2 <=> (S)-4-hydroxymandelate + CO2","pmd":12}
{"X":4569,"KEGG":"R05779","RHEA_ID":22387,"DIRECTION":"BI","MASTER_ID":22384,"compounds":"5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O <=> 1D-myo-inositol hexakisphosphate + H(+) + phosphate","pmd":79.966}
{"X":4570,"KEGG":"R05780","RHEA_ID":21467,"DIRECTION":"BI","MASTER_ID":21464,"compounds":"2 H(+) + H2O + thiocyanate <=> carbonyl sulfide + NH4(+)"}
{"X":4571,"KEGG":"R05781","RHEA_ID":24479,"DIRECTION":"BI","MASTER_ID":24476,"compounds":"H2O + maleimide <=> H(+) + maleamate"}
{"X":4572,"KEGG":"R05782","RHEA_ID":17584,"DIRECTION":"BI","MASTER_ID":17581,"metacyc":"3.5.1.87-RXN","compounds":"an N-carbamoyl-L-2-amino acid + 2 H(+) + H2O <=> an L-alpha-amino acid + CO2 + NH4(+)"}
{"X":4573,"KEGG":"R05783","RHEA_ID":22879,"DIRECTION":"BI","MASTER_ID":22876,"metacyc":"3.5.1.86-RXN","compounds":"(R)-mandelamide + H2O <=> (R)-mandelate + NH4(+)","pmd":0.984}
{"X":4574,"KEGG":"R05784","RHEA_ID":10703,"DIRECTION":"BI","MASTER_ID":10700,"compounds":"H2O + limonene 1,2-epoxide <=> limonene-1,2-diol","pmd":18.011}
{"X":4575,"KEGG":"R05788","RHEA_ID":24483,"DIRECTION":"BI","MASTER_ID":24480,"compounds":"a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O <=> a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol"}
{"X":4576,"KEGG":"R05789","RHEA_ID":23419,"DIRECTION":"BI","MASTER_ID":23416,"compounds":"(2R)-O-phospho-3-sulfolactate + H2O <=> (R)-3-sulfolactate + phosphate","pmd":79.966}
{"X":4577,"KEGG":"R05790","RHEA_ID":19312,"DIRECTION":"BI","MASTER_ID":19309,"compounds":"2-O-(alpha-D-mannosyl)-3-phosphoglycerate + H2O <=> (2R)-2-O-(alpha-D-mannosyl)-glycerate + phosphate","pmd":79.966}
{"X":4578,"KEGG":"R05791","RHEA_ID":22655,"DIRECTION":"BI","MASTER_ID":22652,"compounds":"2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + H2O <=> 2-O-(alpha-D-glucopyranosyl)glycerol + phosphate","pmd":79.966}
{"X":4579,"KEGG":"R05794","RHEA_ID":14600,"DIRECTION":"BI","MASTER_ID":14597,"compounds":"a CDP-1,2-diacyl-sn-glycerol + choline <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)","pmd":218.944}
{"X":4580,"KEGG":"R05795","RHEA_ID":18376,"DIRECTION":"BI","MASTER_ID":18373,"compounds":"1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)","pmd":79.966}
{"X":4581,"KEGG":"R05797","RHEA_ID":11251,"DIRECTION":"BI","MASTER_ID":11248,"compounds":"[(3R)-hydroxybutanoate](n) + H2O <=> (R)-3-hydroxybutanoate + [(3R)-hydroxybutanoate](n-1) + H(+)"}
{"X":4582,"KEGG":"R05797","RHEA_ID":56403,"DIRECTION":"BI","MASTER_ID":56400,"compounds":"[(3R)-hydroxybutanoate](n) + H2O <=> (3R)-hydroxybutanoate tetramer + [(3R)-hydroxybutanoate](n-4) + H(+)"}
{"X":4583,"KEGG":"R05797","RHEA_ID":56399,"DIRECTION":"BI","MASTER_ID":56396,"compounds":"[(3R)-hydroxybutanoate](n) + H2O <=> (3R)-hydroxybutanoate trimer + [(3R)-hydroxybutanoate](n-3) + H(+)"}
{"X":4584,"KEGG":"R05797","RHEA_ID":56407,"DIRECTION":"BI","MASTER_ID":56404,"compounds":"[(3R)-hydroxybutanoate](n) + H2O <=> (3R)-hydroxybutanoate pentamer + [(3R)-hydroxybutanoate](n-5) + H(+)"}
{"X":4585,"KEGG":"R05798","RHEA_ID":15464,"DIRECTION":"BI","MASTER_ID":15461,"compounds":"3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) <=> 3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)","pmd":79.957}
{"X":4586,"KEGG":"R05799","RHEA_ID":12796,"DIRECTION":"BI","MASTER_ID":12793,"compounds":"1D-myo-inositol hexakisphosphate + ATP <=> 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ADP","pmd":79.966}
{"X":4587,"KEGG":"R05799","RHEA_ID":37462,"DIRECTION":"BI","MASTER_ID":37459,"compounds":"1D-myo-inositol hexakisphosphate + ATP <=> 1-diphospho-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP","pmd":79.966}
{"X":4588,"KEGG":"R05800","RHEA_ID":17720,"DIRECTION":"BI","MASTER_ID":17717,"compounds":"1D-myo-inositol 1,4,5-trisphosphate + ATP <=> 1D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + H(+)","pmd":7.067}
{"X":4589,"KEGG":"R05801","RHEA_ID":11859,"DIRECTION":"BI","MASTER_ID":11856,"compounds":"1D-myo-inositol 1,4,5,6-tetrakisphosphate + ATP <=> 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)","pmd":72.899}
{"X":4590,"KEGG":"R05802","RHEA_ID":13612,"DIRECTION":"BI","MASTER_ID":13609,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)","pmd":79.966}
{"X":4591,"KEGG":"R05803","RHEA_ID":12283,"DIRECTION":"BI","MASTER_ID":12280,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)","pmd":79.966}
{"X":4592,"KEGG":"R05804","RHEA_ID":11463,"DIRECTION":"BI","MASTER_ID":11460,"compounds":"ADP + D-glucose <=> AMP + D-glucose 6-phosphate + H(+)","pmd":79.966}
{"X":4593,"KEGG":"R05805","RHEA_ID":20108,"DIRECTION":"BI","MASTER_ID":20105,"metacyc":"R302-RXN","compounds":"ADP + beta-D-fructose 6-phosphate <=> AMP + beta-D-fructose 1,6-bisphosphate + H(+)","pmd":79.966}
{"X":4594,"KEGG":"R05806","RHEA_ID":12143,"DIRECTION":"BI","MASTER_ID":12140,"compounds":"a 2'-deoxyribonucleoside + ATP <=> a 2'-deoxyribonucleoside 5'-phosphate + ADP + H(+)","pmd":79.966}
{"X":4595,"KEGG":"R05807","RHEA_ID":15896,"DIRECTION":"BI","MASTER_ID":15893,"compounds":"Co-sirohydrochlorin + 2 H(+) <=> Co(2+) + sirohydrochlorin","pmd":56.918}
{"X":4596,"KEGG":"R05808","RHEA_ID":18000,"DIRECTION":"BI","MASTER_ID":17997,"compounds":"Co-precorrin-2 + S-adenosyl-L-methionine <=> Co-precorrin-3 + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":4597,"KEGG":"R05809","RHEA_ID":26276,"DIRECTION":"BI","MASTER_ID":26273,"compounds":"Co-precorrin-3 + S-adenosyl-L-methionine <=> Co-precorrin-4 + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":4598,"KEGG":"R05810","RHEA_ID":26280,"DIRECTION":"BI","MASTER_ID":26277,"compounds":"Co-precorrin-4 + S-adenosyl-L-methionine <=> Co-precorrin-5A + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":4599,"KEGG":"R05812","RHEA_ID":15628,"DIRECTION":"BI","MASTER_ID":15625,"compounds":"Co-precorrin-6B + NAD(+) <=> Co-precorrin-6A + H(+) + NADH","pmd":2.016}
{"X":4600,"KEGG":"R05812","RHEA_ID":15628,"DIRECTION":"BI","MASTER_ID":15625,"compounds":"Co-precorrin-6B + NAD(+) <=> Co-precorrin-6A + H(+) + NADH","pmd":289.17}
{"X":4601,"KEGG":"R05814","RHEA_ID":16212,"DIRECTION":"BI","MASTER_ID":16209,"compounds":"Co-precorrin-8X <=> cob(II)yrinate","pmd":0}
{"X":4602,"KEGG":"R05815","RHEA_ID":26292,"DIRECTION":"BI","MASTER_ID":26289,"compounds":"2 ATP + cob(II)yrinate + 2 H2O + 2 L-glutamine <=> 2 ADP + cob(II)yrinate a,c diamide + 2 H(+) + 2 L-glutamate + 2 phosphate","pmd":0.984}
{"X":4603,"KEGG":"R05815","RHEA_ID":26292,"DIRECTION":"BI","MASTER_ID":26289,"compounds":"2 ATP + cob(II)yrinate + 2 H2O + 2 L-glutamine <=> 2 ADP + cob(II)yrinate a,c diamide + 2 H(+) + 2 L-glutamate + 2 phosphate","pmd":1.968}
{"X":4604,"KEGG":"R05815","RHEA_ID":26292,"DIRECTION":"BI","MASTER_ID":26289,"compounds":"2 ATP + cob(II)yrinate + 2 H2O + 2 L-glutamine <=> 2 ADP + cob(II)yrinate a,c diamide + 2 H(+) + 2 L-glutamate + 2 phosphate","pmd":79.966}
{"X":4605,"KEGG":"R05817","RHEA_ID":15312,"DIRECTION":"BI","MASTER_ID":15309,"compounds":"(2R,3Z)-phycocyanobilin + 4 oxidized [2Fe-2S]-[ferredoxin] <=> biliverdin IXalpha + 4 H(+) + 4 reduced [2Fe-2S]-[ferredoxin]","pmd":4.031}
{"X":4606,"KEGG":"R05818","RHEA_ID":10171,"DIRECTION":"BI","MASTER_ID":10168,"compounds":"15,16-dihydrobiliverdin + oxidized 2[4Fe-4S]-[ferredoxin] <=> biliverdin IXalpha + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]","pmd":2.016}
{"X":4607,"KEGG":"R05819","RHEA_ID":22095,"DIRECTION":"BI","MASTER_ID":22092,"compounds":"(3Z)-phycoerythrobilin + oxidized 2[4Fe-4S]-[ferredoxin] <=> 15,16-dihydrobiliverdin + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]","pmd":2.016}
{"X":4608,"KEGG":"R05820","RHEA_ID":42487,"DIRECTION":"BI","MASTER_ID":42484,"compounds":"D-sorbitol(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-sorbitol 6-phosphate(in) + L-histidyl-[protein]","pmd":79.966}
{"X":4609,"KEGG":"R05821","RHEA_ID":28654,"DIRECTION":"BI","MASTER_ID":28651,"compounds":"inosine + O2 <=> 9-riburonosylhypoxanthine + H(+) + H2O","pmd":13.979}
{"X":4610,"KEGG":"R05822","RHEA_ID":19960,"DIRECTION":"BI","MASTER_ID":19957,"compounds":"2 5'-dehydroinosine + O2 <=> 2 9-riburonosylhypoxanthine + 2 H(+)","pmd":15.995}
{"X":4611,"KEGG":"R05823","RHEA_ID":23831,"DIRECTION":"BI","MASTER_ID":23828,"ecocyc":"1.1.1.274-RXN","metacyc":"1.1.1.274-RXN","compounds":"2-dehydro-D-gluconate + NADP(+) <=> 2,5-didehydro-D-gluconate + H(+) + NADPH","pmd":552.056}
{"X":4612,"KEGG":"R05823","RHEA_ID":23831,"DIRECTION":"BI","MASTER_ID":23828,"ecocyc":"1.1.1.274-RXN","metacyc":"1.1.1.274-RXN","compounds":"2-dehydro-D-gluconate + NADP(+) <=> 2,5-didehydro-D-gluconate + H(+) + NADPH","pmd":2.016}
{"X":4613,"KEGG":"R05825","RHEA_ID":17504,"DIRECTION":"BI","MASTER_ID":17501,"compounds":"H2O + polyneuridine aldehyde <=> 16-epivellosimine + CO2 + methanol","pmd":58.005}
{"X":4614,"KEGG":"R05827","RHEA_ID":20032,"DIRECTION":"BI","MASTER_ID":20029,"compounds":"10-deoxysarpagine + NADP(+) <=> H(+) + NADPH + vellosimine","pmd":2.016}
{"X":4615,"KEGG":"R05827","RHEA_ID":20032,"DIRECTION":"BI","MASTER_ID":20029,"compounds":"10-deoxysarpagine + NADP(+) <=> H(+) + NADPH + vellosimine","pmd":451.926}
{"X":4616,"KEGG":"R05828","RHEA_ID":14240,"DIRECTION":"BI","MASTER_ID":14237,"compounds":"10-deoxysarpagine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sarpagine","pmd":15.995}
{"X":4617,"KEGG":"R05832","RHEA_ID":57579,"DIRECTION":"BI","MASTER_ID":57576,"compounds":"7-deoxyloganate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + loganate + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":4618,"KEGG":"R05835","RHEA_ID":19356,"DIRECTION":"BI","MASTER_ID":19353,"compounds":"glycocholate + H2O <=> cholate + glycine","pmd":57.021}
{"X":4619,"KEGG":"R05837","RHEA_ID":32278,"DIRECTION":"BI","MASTER_ID":32275,"compounds":"4-(phosphooxy)-L-threonine + NAD(+) <=> 3-amino-2-oxopropyl phosphate + CO2 + NADH","pmd":46.005}
{"X":4620,"KEGG":"R05837","RHEA_ID":32278,"DIRECTION":"BI","MASTER_ID":32275,"compounds":"4-(phosphooxy)-L-threonine + NAD(+) <=> 3-amino-2-oxopropyl phosphate + CO2 + NADH","pmd":495.103}
{"X":4621,"KEGG":"R05838","RHEA_ID":15268,"DIRECTION":"BI","MASTER_ID":15265,"compounds":"1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate <=> H(+) + 2 H2O + phosphate + pyridoxine 5'-phosphate","pmd":80.026}
{"X":4622,"KEGG":"R05838","RHEA_ID":15268,"DIRECTION":"BI","MASTER_ID":15265,"compounds":"1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate <=> H(+) + 2 H2O + phosphate + pyridoxine 5'-phosphate","pmd":35.016}
{"X":4623,"KEGG":"R05841","RHEA_ID":27853,"DIRECTION":"BI","MASTER_ID":27850,"compounds":"glycine + phenylacetyl-CoA <=> CoA + H(+) + phenylacetylglycine","pmd":118.042}
{"X":4624,"KEGG":"R05850","RHEA_ID":22371,"DIRECTION":"BI","MASTER_ID":22368,"ecocyc":"RIBULPEPIM-RXN","metacyc":"RIBULPEPIM-RXN","compounds":"L-ribulose 5-phosphate <=> D-xylulose 5-phosphate","pmd":0}
{"X":4625,"KEGG":"R05855","RHEA_ID":14136,"DIRECTION":"BI","MASTER_ID":14133,"compounds":"(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] <=> 16-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":4626,"KEGG":"R05856","RHEA_ID":42375,"DIRECTION":"BI","MASTER_ID":42372,"compounds":"16-methoxytabersonine + H2O <=> (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine","pmd":18.011}
{"X":4627,"KEGG":"R05857","RHEA_ID":18976,"DIRECTION":"BI","MASTER_ID":18973,"compounds":"2-oxoglutarate + deacetoxyvindoline + O2 <=> 4-O-deacetylvindoline + CO2 + succinate","pmd":27.995}
{"X":4628,"KEGG":"R05857","RHEA_ID":18976,"DIRECTION":"BI","MASTER_ID":18973,"compounds":"2-oxoglutarate + deacetoxyvindoline + O2 <=> 4-O-deacetylvindoline + CO2 + succinate","pmd":15.995}
{"X":4629,"KEGG":"R05861","RHEA_ID":22691,"DIRECTION":"BI","MASTER_ID":22688,"compounds":"D-alanine + H2O + O2 <=> H2O2 + NH4(+) + pyruvate"}
{"X":4630,"KEGG":"R05862","RHEA_ID":15168,"DIRECTION":"BI","MASTER_ID":15165,"compounds":"H2O + O2 + sarcosine <=> glyoxylate + H2O2 + methylamine"}
{"X":4631,"KEGG":"R05863","RHEA_ID":12475,"DIRECTION":"BI","MASTER_ID":12472,"compounds":"H2O + N-ethylglycine + O2 <=> ethylamine + glyoxylate + H2O2"}
{"X":4632,"KEGG":"R05866","RHEA_ID":61059,"DIRECTION":"BI","MASTER_ID":61056,"compounds":"(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + lochnericine + oxidized [NADPH--hemoprotein reductase]","pmd":392.912}
{"X":4633,"KEGG":"R05866","RHEA_ID":61059,"DIRECTION":"BI","MASTER_ID":61056,"compounds":"(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + lochnericine + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":4634,"KEGG":"R05867","RHEA_ID":61051,"DIRECTION":"BI","MASTER_ID":61048,"compounds":"lochnericine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + horhammericine + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":4635,"KEGG":"R05870","RHEA_ID":61079,"DIRECTION":"BI","MASTER_ID":61076,"compounds":"(-)-minovincinine + acetyl-CoA <=> (-)-echitovenine + CoA","pmd":42.011}
{"X":4636,"KEGG":"R05872","RHEA_ID":61047,"DIRECTION":"BI","MASTER_ID":61044,"compounds":"(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] <=> (-)-(R)-19-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":4637,"KEGG":"R05875","RHEA_ID":16524,"DIRECTION":"BI","MASTER_ID":16521,"ecocyc":"FERREDOXIN--NAD%2b-REDUCTASE-RXN","metacyc":"RXN-14040","compounds":"H(+) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> NADH + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":4638,"KEGG":"R05875","RHEA_ID":16524,"DIRECTION":"BI","MASTER_ID":16521,"ecocyc":"FERREDOXIN--NAD%2b-REDUCTASE-RXN","metacyc":"FERREDOXIN--NAD%2b-REDUCTASE-RXN","compounds":"H(+) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> NADH + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":4639,"KEGG":"R05876","RHEA_ID":24019,"DIRECTION":"BI","MASTER_ID":24016,"metacyc":"2.3.1.160-RXN","compounds":"16-epivellosimine + acetyl-CoA <=> CoA + vinorine","pmd":42.01}
{"X":4640,"KEGG":"R05876","RHEA_ID":24019,"DIRECTION":"BI","MASTER_ID":24016,"metacyc":"2.3.1.160-RXN","compounds":"16-epivellosimine + acetyl-CoA <=> CoA + vinorine","pmd":42.011}
{"X":4641,"KEGG":"R05877","RHEA_ID":17260,"DIRECTION":"BI","MASTER_ID":17257,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + vinorine <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + vomilenine","pmd":15.995}
{"X":4642,"KEGG":"R05878","RHEA_ID":16412,"DIRECTION":"BI","MASTER_ID":16409,"compounds":"1,2-dihydrovomilenine + NADP(+) <=> H(+) + NADPH + vomilenine","pmd":2.016}
{"X":4643,"KEGG":"R05878","RHEA_ID":16412,"DIRECTION":"BI","MASTER_ID":16409,"compounds":"1,2-dihydrovomilenine + NADP(+) <=> H(+) + NADPH + vomilenine","pmd":393.92}
{"X":4644,"KEGG":"R05879","RHEA_ID":12323,"DIRECTION":"BI","MASTER_ID":12320,"compounds":"17-O-acetylnorajmaline + NADP(+) <=> 1,2-dihydrovomilenine + 2 H(+) + NADPH","pmd":2.016}
{"X":4645,"KEGG":"R05879","RHEA_ID":12323,"DIRECTION":"BI","MASTER_ID":12320,"compounds":"17-O-acetylnorajmaline + NADP(+) <=> 1,2-dihydrovomilenine + 2 H(+) + NADPH","pmd":391.905}
{"X":4646,"KEGG":"R05880","RHEA_ID":23799,"DIRECTION":"BI","MASTER_ID":23796,"compounds":"17-O-acetylnorajmaline + H2O <=> acetate + H(+) + norajmaline","pmd":42.01}
{"X":4647,"KEGG":"R05882","RHEA_ID":19388,"DIRECTION":"BI","MASTER_ID":19385,"compounds":"UDP-alpha-D-glucose + vomilenine <=> H(+) + raucaffricine + UDP","pmd":53.839}
{"X":4648,"KEGG":"R05884","RHEA_ID":24491,"DIRECTION":"BI","MASTER_ID":24488,"compounds":"H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] <=> (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]","pmd":15.995}
{"X":4649,"KEGG":"R05885","RHEA_ID":20995,"DIRECTION":"BI","MASTER_ID":20992,"compounds":"16-hydroxytabersonine + S-adenosyl-L-methionine <=> 16-methoxytabersonine + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":4650,"KEGG":"R05901","RHEA_ID":56223,"DIRECTION":"BI","MASTER_ID":56220,"compounds":"3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-seryl-[protein] + H(+) + UDP"}
{"X":4651,"KEGG":"R05901","RHEA_ID":56227,"DIRECTION":"BI","MASTER_ID":56224,"compounds":"3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-threonyl-[protein] + H(+) + UDP"}
{"X":4652,"KEGG":"R05907","RHEA_ID":23959,"DIRECTION":"BI","MASTER_ID":23956,"compounds":"L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP"}
{"X":4653,"KEGG":"R05908","RHEA_ID":56199,"DIRECTION":"BI","MASTER_ID":56196,"compounds":"3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-alpha-D-galactose <=> H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP"}
{"X":4654,"KEGG":"R05908","RHEA_ID":56203,"DIRECTION":"BI","MASTER_ID":56200,"compounds":"3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-alpha-D-galactose <=> H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP"}
{"X":4655,"KEGG":"R05909","RHEA_ID":46883,"DIRECTION":"BI","MASTER_ID":46880,"metacyc":"2.4.1.147-RXN","compounds":"3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP"}
{"X":4656,"KEGG":"R05909","RHEA_ID":46887,"DIRECTION":"BI","MASTER_ID":46884,"metacyc":"2.4.1.147-RXN","compounds":"3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP"}
{"X":4657,"KEGG":"R05912","RHEA_ID":56215,"DIRECTION":"BI","MASTER_ID":56212,"compounds":"O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP"}
{"X":4658,"KEGG":"R05912","RHEA_ID":56219,"DIRECTION":"BI","MASTER_ID":56216,"compounds":"O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP"}
{"X":4659,"KEGG":"R05913","RHEA_ID":56207,"DIRECTION":"BI","MASTER_ID":56204,"compounds":"CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] <=> 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + CMP + H(+)"}
{"X":4660,"KEGG":"R05913","RHEA_ID":56211,"DIRECTION":"BI","MASTER_ID":56208,"compounds":"CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] <=> 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP + H(+)"}
{"X":4661,"KEGG":"R05915","RHEA_ID":56191,"DIRECTION":"BI","MASTER_ID":56188,"compounds":"3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP"}
{"X":4662,"KEGG":"R05915","RHEA_ID":56195,"DIRECTION":"BI","MASTER_ID":56192,"compounds":"3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP"}
{"X":4663,"KEGG":"R05925","RHEA_ID":50195,"DIRECTION":"BI","MASTER_ID":50192,"compounds":"L-seryl-[protein] + UDP-alpha-D-xylose <=> 3-O-(beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP"}
{"X":4664,"KEGG":"R05926","RHEA_ID":15300,"DIRECTION":"BI","MASTER_ID":15297,"compounds":"3-O-(beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose <=> 3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP"}
{"X":4665,"KEGG":"R05927","RHEA_ID":11783,"DIRECTION":"BI","MASTER_ID":11780,"compounds":"3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose <=> 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP"}
{"X":4666,"KEGG":"R05928","RHEA_ID":24171,"DIRECTION":"BI","MASTER_ID":24168,"compounds":"3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate <=> 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP"}
{"X":4667,"KEGG":"R05929","RHEA_ID":23467,"DIRECTION":"BI","MASTER_ID":23464,"compounds":"3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP"}
{"X":4668,"KEGG":"R05930","RHEA_ID":16224,"DIRECTION":"BI","MASTER_ID":16221,"compounds":"3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP"}
{"X":4669,"KEGG":"R05931","RHEA_ID":23431,"DIRECTION":"BI","MASTER_ID":23428,"compounds":"3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate <=> 3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP"}
{"X":4670,"KEGG":"R05931","RHEA_ID":54999,"DIRECTION":"BI","MASTER_ID":54996,"compounds":"3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate <=> 3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP"}
{"X":4671,"KEGG":"R05932","RHEA_ID":20803,"DIRECTION":"BI","MASTER_ID":20800,"compounds":"3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP"}
{"X":4672,"KEGG":"R05961","RHEA_ID":21115,"DIRECTION":"BI","MASTER_ID":21112,"compounds":"globoside Gb3Cer (d18:1(4E)) + H2O <=> a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + D-galactose"}
{"X":4673,"KEGG":"R05973","RHEA_ID":29518,"DIRECTION":"BI","MASTER_ID":29515,"compounds":"beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose <=> alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)"}
{"X":4674,"KEGG":"R05976","RHEA_ID":50351,"DIRECTION":"BI","MASTER_ID":50348,"compounds":"alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] <=> dolichyl diphosphate + H(+) + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein]"}
{"X":4675,"KEGG":"R05977","RHEA_ID":31502,"DIRECTION":"BI","MASTER_ID":31499,"metacyc":"RXN-12113","compounds":"a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose <=> a neolactoside nLc4Cer(d18:1(4E)) + H(+) + UDP"}
{"X":4676,"KEGG":"R05980","RHEA_ID":55999,"DIRECTION":"BI","MASTER_ID":55996,"compounds":"H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] <=> beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein]"}
{"X":4677,"KEGG":"R05981","RHEA_ID":56003,"DIRECTION":"BI","MASTER_ID":56000,"compounds":"H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] <=> beta-D-glucose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3)"}
{"X":4678,"KEGG":"R05982","RHEA_ID":56011,"DIRECTION":"BI","MASTER_ID":56008,"compounds":"4 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) <=> 4 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)"}
{"X":4679,"KEGG":"R05983","RHEA_ID":11459,"DIRECTION":"BI","MASTER_ID":11456,"compounds":"N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP"}
{"X":4680,"KEGG":"R05984","RHEA_ID":56055,"DIRECTION":"BI","MASTER_ID":56052,"compounds":"2 H2O + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] <=> 2 alpha-D-mannopyranose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]"}
{"X":4681,"KEGG":"R05985","RHEA_ID":12944,"DIRECTION":"BI","MASTER_ID":12941,"compounds":"N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP"}
{"X":4682,"KEGG":"R05986","RHEA_ID":15512,"DIRECTION":"BI","MASTER_ID":15509,"compounds":"N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP"}
{"X":4683,"KEGG":"R05986","RHEA_ID":56067,"DIRECTION":"BI","MASTER_ID":56064,"compounds":"3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose <=> 3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP"}
{"X":4684,"KEGG":"R05987","RHEA_ID":16060,"DIRECTION":"BI","MASTER_ID":16057,"compounds":"N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP"}
{"X":4685,"KEGG":"R05988","RHEA_ID":12988,"DIRECTION":"BI","MASTER_ID":12985,"metacyc":"2.4.1.68-RXN","compounds":"GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] <=> GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein]"}
{"X":4686,"KEGG":"R05991","RHEA_ID":16924,"DIRECTION":"BI","MASTER_ID":16921,"compounds":"N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP"}
{"X":4687,"KEGG":"R05991","RHEA_ID":56091,"DIRECTION":"BI","MASTER_ID":56088,"compounds":"CMP-N-acetyl-beta-neuraminate + globoside MSGG <=> CMP + globoside DSGG + H(+)"}
{"X":4688,"KEGG":"R05992","RHEA_ID":19948,"DIRECTION":"BI","MASTER_ID":19945,"compounds":"N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP"}
{"X":4689,"KEGG":"R06015","RHEA_ID":24447,"DIRECTION":"BI","MASTER_ID":24444,"metacyc":"2.4.1.214-RXN","compounds":"GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] <=> GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[(1->4)-alpha-L-Fuc]-beta-D-GlcNAc}-L-asparaginyl-[protein]"}
{"X":4690,"KEGG":"R06016","RHEA_ID":10615,"DIRECTION":"BI","MASTER_ID":10612,"metacyc":"2.4.2.38-RXN","compounds":"N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-alpha-D-xylose <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP"}
{"X":4691,"KEGG":"R06026","RHEA_ID":18916,"DIRECTION":"BI","MASTER_ID":18913,"compounds":"a neolactoside nLc4Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + CMP + H(+)"}
{"X":4692,"KEGG":"R06047","RHEA_ID":20955,"DIRECTION":"BI","MASTER_ID":20952,"compounds":"N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UDP-alpha-D-glucose <=> beta-D-glucosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP","pmd":162.053}
{"X":4693,"KEGG":"R06048","RHEA_ID":12007,"DIRECTION":"BI","MASTER_ID":12004,"compounds":"indoxyl + UDP-alpha-D-glucose <=> H(+) + indican + UDP","pmd":162.053}
{"X":4694,"KEGG":"R06050","RHEA_ID":41735,"DIRECTION":"BI","MASTER_ID":41732,"ecocyc":"RXN0-5184","metacyc":"RXN0-5184","compounds":"[(1->4)-alpha-D-glucosyl](n) + phosphate <=> [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate"}
{"X":4695,"KEGG":"R06051","RHEA_ID":18552,"DIRECTION":"BI","MASTER_ID":18549,"compounds":"[(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose <=> [(1->4)-alpha-D-glucosyl](n+1) + H(+) + UDP"}
{"X":4696,"KEGG":"R06117","RHEA_ID":14828,"DIRECTION":"BI","MASTER_ID":14825,"compounds":"(1R,5S)-carveol + NAD(+) <=> (S)-carvone + H(+) + NADH","pmd":2.016}
{"X":4697,"KEGG":"R06117","RHEA_ID":14828,"DIRECTION":"BI","MASTER_ID":14825,"compounds":"(1R,5S)-carveol + NAD(+) <=> (S)-carvone + H(+) + NADH","pmd":514.012}
{"X":4698,"KEGG":"R06119","RHEA_ID":18960,"DIRECTION":"BI","MASTER_ID":18957,"compounds":"(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] <=> (1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":4699,"KEGG":"R06120","RHEA_ID":10943,"DIRECTION":"BI","MASTER_ID":10940,"compounds":"(2E)-geranyl diphosphate <=> (4R)-limonene + diphosphate","pmd":177.943}
{"X":4700,"KEGG":"R06126","RHEA_ID":21599,"DIRECTION":"BI","MASTER_ID":21596,"compounds":"L-serine + NADP(+) <=> 2-aminomalonate semialdehyde + H(+) + NADPH","pmd":641.056}
{"X":4701,"KEGG":"R06126","RHEA_ID":21599,"DIRECTION":"BI","MASTER_ID":21596,"compounds":"L-serine + NADP(+) <=> 2-aminomalonate semialdehyde + H(+) + NADPH","pmd":2.016}
{"X":4702,"KEGG":"R06127","RHEA_ID":29526,"DIRECTION":"BI","MASTER_ID":29523,"compounds":"alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose <=> alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H(+)"}
{"X":4703,"KEGG":"R06140","RHEA_ID":54543,"DIRECTION":"BI","MASTER_ID":54540,"compounds":"H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] <=> beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-threonyl-[protein]"}
{"X":4704,"KEGG":"R06154","RHEA_ID":59423,"DIRECTION":"BI","MASTER_ID":59420,"compounds":"H2O + methylamine + O2 <=> formaldehyde + H2O2 + NH4(+)"}
{"X":4705,"KEGG":"R06160","RHEA_ID":23983,"DIRECTION":"BI","MASTER_ID":23980,"compounds":"cyclomaltodextrin + H2O <=> linear maltodextrin"}
{"X":4706,"KEGG":"R06166","RHEA_ID":22947,"DIRECTION":"BI","MASTER_ID":22944,"compounds":"3beta-hydroxy-5beta-pregnane-20-one + NADP(+) <=> 5beta-pregnan-3,20-dione + H(+) + NADPH","pmd":2.016}
{"X":4707,"KEGG":"R06166","RHEA_ID":22947,"DIRECTION":"BI","MASTER_ID":22944,"compounds":"3beta-hydroxy-5beta-pregnane-20-one + NADP(+) <=> 5beta-pregnan-3,20-dione + H(+) + NADPH","pmd":427.843}
{"X":4708,"KEGG":"R06171","RHEA_ID":26212,"DIRECTION":"BI","MASTER_ID":26209,"compounds":"L-allo-threonine <=> acetaldehyde + glycine"}
{"X":4709,"KEGG":"R06178","RHEA_ID":23711,"DIRECTION":"BI","MASTER_ID":23708,"compounds":"[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-diphospho-di-trans,octa-cis-undecaprenol + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol <=> [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-diphospho-di-trans-octa-cis-undecaprenol + di-trans,octa-cis-undecaprenyl diphosphate + H(+)"}
{"X":4710,"KEGG":"R06180","RHEA_ID":15212,"DIRECTION":"BI","MASTER_ID":15209,"ecocyc":"TARTRATE-DEHYDROGENASE-RXN","metacyc":"TARTRATE-DEHYDROGENASE-RXN","compounds":"(2R,3R)-tartrate + NAD(+) <=> 2-hydroxy-3-oxosuccinate + H(+) + NADH","pmd":2.016}
{"X":4711,"KEGG":"R06180","RHEA_ID":15212,"DIRECTION":"BI","MASTER_ID":15209,"ecocyc":"TARTRATE-DEHYDROGENASE-RXN","metacyc":"TARTRATE-DEHYDROGENASE-RXN","compounds":"(2R,3R)-tartrate + NAD(+) <=> 2-hydroxy-3-oxosuccinate + H(+) + NADH","pmd":516.116}
{"X":4712,"KEGG":"R06182","RHEA_ID":21015,"DIRECTION":"BI","MASTER_ID":21012,"compounds":"4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine <=> 4-O-([2-N-acetyl-alpha-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP"}
{"X":4713,"KEGG":"R06223","RHEA_ID":32298,"DIRECTION":"BI","MASTER_ID":32295,"compounds":"2 (2E,6E)-farnesyl diphosphate + H(+) + NADPH <=> 2 diphosphate + NADP(+) + squalene","pmd":334.7}
{"X":4714,"KEGG":"R06223","RHEA_ID":32298,"DIRECTION":"BI","MASTER_ID":32295,"compounds":"2 (2E,6E)-farnesyl diphosphate + H(+) + NADPH <=> 2 diphosphate + NADP(+) + squalene","pmd":28.26}
{"X":4715,"KEGG":"R06234","RHEA_ID":60063,"DIRECTION":"BI","MASTER_ID":60060,"compounds":"a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose <=> alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP"}
{"X":4716,"KEGG":"R06238","RHEA_ID":29522,"DIRECTION":"BI","MASTER_ID":29519,"compounds":"alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose <=> alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)"}
{"X":4717,"KEGG":"R06240","RHEA_ID":57107,"DIRECTION":"BI","MASTER_ID":57104,"compounds":"[(1->4)-alpha-D-galacturonosyl](n) <=> 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate + [(1->4)-alpha-D-galacturonosyl](n-2)"}
{"X":4718,"KEGG":"R06242","RHEA_ID":50243,"DIRECTION":"BI","MASTER_ID":50240,"compounds":"[hyaluronan](n) <=> n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine + H2O"}
{"X":4719,"KEGG":"R06258","RHEA_ID":29530,"DIRECTION":"BI","MASTER_ID":29527,"compounds":"alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate <=> alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+)"}
{"X":4720,"KEGG":"R06259","RHEA_ID":29534,"DIRECTION":"BI","MASTER_ID":29531,"compounds":"alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate <=> alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+)"}
{"X":4721,"KEGG":"R06260","RHEA_ID":29538,"DIRECTION":"BI","MASTER_ID":29535,"compounds":"alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate <=> alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+)"}
{"X":4722,"KEGG":"R06261","RHEA_ID":29542,"DIRECTION":"BI","MASTER_ID":29539,"compounds":"alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate <=> alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+)"}
{"X":4723,"KEGG":"R06262","RHEA_ID":30638,"DIRECTION":"BI","MASTER_ID":30635,"compounds":"alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate <=> alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+)"}
{"X":4724,"KEGG":"R06263","RHEA_ID":31310,"DIRECTION":"BI","MASTER_ID":31307,"compounds":"alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate <=> alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+)"}
{"X":4725,"KEGG":"R06264","RHEA_ID":29546,"DIRECTION":"BI","MASTER_ID":29543,"compounds":"alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate <=> alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+)"}
{"X":4726,"KEGG":"R06265","RHEA_ID":24275,"DIRECTION":"BI","MASTER_ID":24272,"compounds":"H(+) + Mg-protoporphyrin IX 13-monomethyl ester + NADPH + O2 <=> H2O + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADP(+)","pmd":130.853}
{"X":4727,"KEGG":"R06265","RHEA_ID":24275,"DIRECTION":"BI","MASTER_ID":24272,"compounds":"H(+) + Mg-protoporphyrin IX 13-monomethyl ester + NADPH + O2 <=> H2O + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADP(+)","pmd":15.995}
{"X":4728,"KEGG":"R06266","RHEA_ID":20544,"DIRECTION":"BI","MASTER_ID":20541,"compounds":"H(+) + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADPH + O2 <=> 2 H2O + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADP(+)","pmd":132.869}
{"X":4729,"KEGG":"R06266","RHEA_ID":20544,"DIRECTION":"BI","MASTER_ID":20541,"compounds":"H(+) + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADPH + O2 <=> 2 H2O + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADP(+)","pmd":2.016}
{"X":4730,"KEGG":"R06267","RHEA_ID":16756,"DIRECTION":"BI","MASTER_ID":16753,"compounds":"Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADPH + O2 <=> 3,8-divinyl protochlorophyllide a + 2 H2O + NADP(+)","pmd":134.884}
{"X":4731,"KEGG":"R06267","RHEA_ID":16756,"DIRECTION":"BI","MASTER_ID":16753,"compounds":"Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADPH + O2 <=> 3,8-divinyl protochlorophyllide a + 2 H2O + NADP(+)","pmd":2.016}
{"X":4732,"KEGG":"R06268","RHEA_ID":49103,"DIRECTION":"BI","MASTER_ID":49100,"compounds":"H2O + Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester","pmd":15.995}
{"X":4733,"KEGG":"R06268","RHEA_ID":49103,"DIRECTION":"BI","MASTER_ID":49100,"compounds":"H2O + Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester","pmd":147.035}
{"X":4734,"KEGG":"R06269","RHEA_ID":49107,"DIRECTION":"BI","MASTER_ID":49104,"compounds":"Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester","pmd":2.016}
{"X":4735,"KEGG":"R06269","RHEA_ID":49107,"DIRECTION":"BI","MASTER_ID":49104,"compounds":"Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester","pmd":147.035}
{"X":4736,"KEGG":"R06270","RHEA_ID":49111,"DIRECTION":"BI","MASTER_ID":49108,"compounds":"Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine <=> 3,8-divinyl protochlorophyllide a + 5'-deoxyadenosine + 2 H(+) + L-methionine","pmd":2.016}
{"X":4737,"KEGG":"R06270","RHEA_ID":49111,"DIRECTION":"BI","MASTER_ID":49108,"compounds":"Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine <=> 3,8-divinyl protochlorophyllide a + 5'-deoxyadenosine + 2 H(+) + L-methionine","pmd":147.035}
{"X":4738,"KEGG":"R06272","RHEA_ID":14452,"DIRECTION":"BI","MASTER_ID":14449,"compounds":"chlorophyllide a + NADP(+) <=> 3,8-divinyl chlorophyllide a + H(+) + NADPH","pmd":2.016}
{"X":4739,"KEGG":"R06272","RHEA_ID":14452,"DIRECTION":"BI","MASTER_ID":14449,"compounds":"chlorophyllide a + NADP(+) <=> 3,8-divinyl chlorophyllide a + H(+) + NADPH","pmd":130.853}
{"X":4740,"KEGG":"R06282","RHEA_ID":28205,"DIRECTION":"BI","MASTER_ID":28202,"compounds":"2 ADP + chlorophyllide a + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate <=> 2 ATP + 2 H2O + protochlorophyllide a + reduced 2[4Fe-4S]-[ferredoxin]","pmd":2.016}
{"X":4741,"KEGG":"R06282","RHEA_ID":28205,"DIRECTION":"BI","MASTER_ID":28202,"compounds":"2 ADP + chlorophyllide a + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate <=> 2 ATP + 2 H2O + protochlorophyllide a + reduced 2[4Fe-4S]-[ferredoxin]","pmd":79.966}
{"X":4742,"KEGG":"R06284","RHEA_ID":17320,"DIRECTION":"BI","MASTER_ID":17317,"metacyc":"RXN1F-66","compounds":"chlorophyllide a + H(+) + phytyl diphosphate <=> chlorophyll a + diphosphate","pmd":436.295}
{"X":4743,"KEGG":"R06284","RHEA_ID":17320,"DIRECTION":"BI","MASTER_ID":17317,"metacyc":"RXN1F-66","compounds":"chlorophyllide a + H(+) + phytyl diphosphate <=> chlorophyll a + diphosphate","pmd":278.297}
{"X":4744,"KEGG":"R06285","RHEA_ID":28065,"DIRECTION":"BI","MASTER_ID":28062,"compounds":"alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate <=> alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)"}
{"X":4745,"KEGG":"R06291","RHEA_ID":13048,"DIRECTION":"BI","MASTER_ID":13045,"compounds":"ent-kaur-16-ene + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-kaur-16-en-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":4746,"KEGG":"R06292","RHEA_ID":21307,"DIRECTION":"BI","MASTER_ID":21304,"compounds":"ent-kaur-16-en-19-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-kaur-16-en-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]","pmd":2.016}
{"X":4747,"KEGG":"R06293","RHEA_ID":10931,"DIRECTION":"BI","MASTER_ID":10928,"compounds":"ent-kaur-16-en-19-al + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-kaur-16-en-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":4748,"KEGG":"R06294","RHEA_ID":19244,"DIRECTION":"BI","MASTER_ID":19241,"compounds":"ent-kaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-7alpha-hydroxykaur-16-en-19-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":4749,"KEGG":"R06295","RHEA_ID":22907,"DIRECTION":"BI","MASTER_ID":22904,"compounds":"ent-7alpha-hydroxykaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> gibberellin A12 aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]","pmd":2.016}
{"X":4750,"KEGG":"R06297","RHEA_ID":22703,"DIRECTION":"BI","MASTER_ID":22700,"compounds":"gibberellin A12 aldehyde + O2 + reduced [NADPH--hemoprotein reductase] <=> gibberellin A12 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":4751,"KEGG":"R06298","RHEA_ID":24319,"DIRECTION":"BI","MASTER_ID":24316,"compounds":"all-trans-geranylgeranyl diphosphate <=> (+)-copalyl diphosphate","pmd":0}
{"X":4752,"KEGG":"R06299","RHEA_ID":42987,"DIRECTION":"BI","MASTER_ID":42984,"compounds":"(+)-copalyl diphosphate <=> diphosphate + pimara-8(14),15-diene","pmd":177.943}
{"X":4753,"KEGG":"R06301","RHEA_ID":13876,"DIRECTION":"BI","MASTER_ID":13873,"compounds":"(+)-copalyl diphosphate <=> abieta-7,13-diene + diphosphate","pmd":177.943}
{"X":4754,"KEGG":"R06302","RHEA_ID":25551,"DIRECTION":"BI","MASTER_ID":25548,"metacyc":"4.2.3.32-RXN","compounds":"(+)-copalyl diphosphate <=> abieta-8(14),12-diene + diphosphate","pmd":177.943}
{"X":4755,"KEGG":"R06303","RHEA_ID":33990,"DIRECTION":"BI","MASTER_ID":33987,"compounds":"(+)-copalyl diphosphate <=> diphosphate + neoabietadiene","pmd":177.943}
{"X":4756,"KEGG":"R06305","RHEA_ID":20915,"DIRECTION":"BI","MASTER_ID":20912,"compounds":"all-trans-geranylgeranyl diphosphate <=> diphosphate + taxa-4,11-diene","pmd":177.943}
{"X":4757,"KEGG":"R06306","RHEA_ID":14052,"DIRECTION":"BI","MASTER_ID":14049,"compounds":"AH2 + O2 + taxa-4,11-diene <=> A + H2O + taxa-4(20),11-dien-5alpha-ol","pmd":15.995}
{"X":4758,"KEGG":"R06307","RHEA_ID":22031,"DIRECTION":"BI","MASTER_ID":22028,"metacyc":"2.3.1.162-RXN","compounds":"acetyl-CoA + taxa-4(20),11-dien-5alpha-ol <=> CoA + taxa-4(20),11-dien-5alpha-yl acetate","pmd":42.011}
{"X":4759,"KEGG":"R06308","RHEA_ID":18952,"DIRECTION":"BI","MASTER_ID":18949,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha,13alpha-diol","pmd":15.995}
{"X":4760,"KEGG":"R06309","RHEA_ID":15244,"DIRECTION":"BI","MASTER_ID":15241,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-yl acetate <=> 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":4761,"KEGG":"R06310","RHEA_ID":18744,"DIRECTION":"BI","MASTER_ID":18741,"compounds":"10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA <=> 10-deacetylbaccatin III + CoA","pmd":104.026}
{"X":4762,"KEGG":"R06311","RHEA_ID":20140,"DIRECTION":"BI","MASTER_ID":20137,"compounds":"10-deacetylbaccatin III + acetyl-CoA <=> baccatin III + CoA","pmd":42.011}
{"X":4763,"KEGG":"R06312","RHEA_ID":25527,"DIRECTION":"BI","MASTER_ID":25524,"compounds":"all-trans-geranylgeranyl diphosphate <=> 9alpha-copalyl diphosphate","pmd":0}
{"X":4764,"KEGG":"R06313","RHEA_ID":26216,"DIRECTION":"BI","MASTER_ID":26213,"compounds":"9alpha-copalyl diphosphate + H2O <=> aphidicolan-16beta-ol + diphosphate","pmd":159.933}
{"X":4765,"KEGG":"R06322","RHEA_ID":60779,"DIRECTION":"BI","MASTER_ID":60776,"compounds":"2-oxoglutarate + gibberellin A12 + O2 <=> CO2 + gibberellin A15 + succinate","pmd":27.995}
{"X":4766,"KEGG":"R06322","RHEA_ID":60779,"DIRECTION":"BI","MASTER_ID":60776,"compounds":"2-oxoglutarate + gibberellin A12 + O2 <=> CO2 + gibberellin A15 + succinate","pmd":15.995}
{"X":4767,"KEGG":"R06323","RHEA_ID":60783,"DIRECTION":"BI","MASTER_ID":60780,"compounds":"2-oxoglutarate + gibberellin A15 + O2 <=> CO2 + gibberellin A24 + H2O + succinate","pmd":2.016}
{"X":4768,"KEGG":"R06323","RHEA_ID":60783,"DIRECTION":"BI","MASTER_ID":60780,"compounds":"2-oxoglutarate + gibberellin A15 + O2 <=> CO2 + gibberellin A24 + H2O + succinate","pmd":27.995}
{"X":4769,"KEGG":"R06351","RHEA_ID":26220,"DIRECTION":"BI","MASTER_ID":26217,"compounds":"abieta-7,13-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> abieta-7,13-dien-18-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":4770,"KEGG":"R06354","RHEA_ID":26224,"DIRECTION":"BI","MASTER_ID":26221,"compounds":"abieta-7,13-dien-18-ol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> abieta-7,13-dien-18-oate + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]","pmd":2.016}
{"X":4771,"KEGG":"R06357","RHEA_ID":26228,"DIRECTION":"BI","MASTER_ID":26225,"compounds":"abieta-7,13-dien-18-al + H2O + NAD(+) <=> abieta-7,13-dien-18-oate + 2 H(+) + NADH","pmd":361.892}
{"X":4772,"KEGG":"R06357","RHEA_ID":26228,"DIRECTION":"BI","MASTER_ID":26225,"compounds":"abieta-7,13-dien-18-al + H2O + NAD(+) <=> abieta-7,13-dien-18-oate + 2 H(+) + NADH","pmd":15.995}
{"X":4773,"KEGG":"R06364","RHEA_ID":36190,"DIRECTION":"BI","MASTER_ID":36187,"compounds":"1-O-alkyl-2-acyl-sn-glycerol + CDP-ethanolamine <=> 1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)","pmd":123.009}
{"X":4774,"KEGG":"R06366","RHEA_ID":31302,"DIRECTION":"BI","MASTER_ID":31299,"compounds":"H2O + NAD(+) + perillyl aldehyde <=> 2 H(+) + NADH + perillate","pmd":15.995}
{"X":4775,"KEGG":"R06366","RHEA_ID":31302,"DIRECTION":"BI","MASTER_ID":31299,"compounds":"H2O + NAD(+) + perillyl aldehyde <=> 2 H(+) + NADH + perillate","pmd":498.017}
{"X":4776,"KEGG":"R06372","RHEA_ID":32430,"DIRECTION":"BI","MASTER_ID":32427,"compounds":"(1R,4S)-isodihydrocarvone + A <=> (S)-carvone + AH2","pmd":2.016}
{"X":4777,"KEGG":"R06373","RHEA_ID":32426,"DIRECTION":"BI","MASTER_ID":32423,"compounds":"(1R,4R)-dihydrocarvone + A <=> (R)-carvone + AH2","pmd":2.016}
{"X":4778,"KEGG":"R06376","RHEA_ID":32390,"DIRECTION":"BI","MASTER_ID":32387,"metacyc":"RXN-9389","compounds":"dihydrocarveol + NAD(+) <=> dihydrocarvone + H(+) + NADH","pmd":511.997}
{"X":4779,"KEGG":"R06376","RHEA_ID":32390,"DIRECTION":"BI","MASTER_ID":32387,"metacyc":"RXN-9389","compounds":"dihydrocarveol + NAD(+) <=> dihydrocarvone + H(+) + NADH","pmd":2.016}
{"X":4780,"KEGG":"R06383","RHEA_ID":32390,"DIRECTION":"BI","MASTER_ID":32387,"metacyc":"RXN-9389","compounds":"dihydrocarveol + NAD(+) <=> dihydrocarvone + H(+) + NADH","pmd":2.016}
{"X":4781,"KEGG":"R06383","RHEA_ID":32390,"DIRECTION":"BI","MASTER_ID":32387,"metacyc":"RXN-9389","compounds":"dihydrocarveol + NAD(+) <=> dihydrocarvone + H(+) + NADH","pmd":511.997}
{"X":4782,"KEGG":"R06386","RHEA_ID":52827,"DIRECTION":"BI","MASTER_ID":52824,"compounds":"(1R,4R)-dihydrocarvone + H(+) + NADPH + O2 <=> (4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)","pmd":576.976}
{"X":4783,"KEGG":"R06386","RHEA_ID":52827,"DIRECTION":"BI","MASTER_ID":52824,"compounds":"(1R,4R)-dihydrocarvone + H(+) + NADPH + O2 <=> (4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)","pmd":15.995}
{"X":4784,"KEGG":"R06388","RHEA_ID":52831,"DIRECTION":"BI","MASTER_ID":52828,"compounds":"(1S,4R)-isodihydrocarvone + H(+) + NADPH + O2 <=> (3S,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)","pmd":15.995}
{"X":4785,"KEGG":"R06388","RHEA_ID":52831,"DIRECTION":"BI","MASTER_ID":52828,"compounds":"(1S,4R)-isodihydrocarvone + H(+) + NADPH + O2 <=> (3S,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)","pmd":576.976}
{"X":4786,"KEGG":"R06390","RHEA_ID":32514,"DIRECTION":"BI","MASTER_ID":32511,"compounds":"(4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O <=> (3R,6R)-6-hydroxy-3-isopropenylheptanoate + H(+)","pmd":18.011}
{"X":4787,"KEGG":"R06392","RHEA_ID":32518,"DIRECTION":"BI","MASTER_ID":32515,"compounds":"(4S,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O <=> (3S,6R)-6-hydroxy-3-isopropenylheptanoate + H(+)","pmd":18.011}
{"X":4788,"KEGG":"R06398","RHEA_ID":26096,"DIRECTION":"BI","MASTER_ID":26093,"compounds":"(4R)-limonene + H(+) + NADH + O2 <=> H2O + limonene 1,2-epoxide + NAD(+)","pmd":513.005}
{"X":4789,"KEGG":"R06398","RHEA_ID":26096,"DIRECTION":"BI","MASTER_ID":26093,"compounds":"(4R)-limonene + H(+) + NADH + O2 <=> H2O + limonene 1,2-epoxide + NAD(+)","pmd":15.995}
{"X":4790,"KEGG":"R06399","RHEA_ID":32386,"DIRECTION":"BI","MASTER_ID":32383,"metacyc":"RXN-9949","compounds":"(1S,2S,4R)-limonene-1,2-diol + NAD(+) <=> (1S,4R)-1-hydroxylimonen-2-one + H(+) + NADH","pmd":496.002}
{"X":4791,"KEGG":"R06399","RHEA_ID":32386,"DIRECTION":"BI","MASTER_ID":32383,"metacyc":"RXN-9949","compounds":"(1S,2S,4R)-limonene-1,2-diol + NAD(+) <=> (1S,4R)-1-hydroxylimonen-2-one + H(+) + NADH","pmd":2.016}
{"X":4792,"KEGG":"R06400","RHEA_ID":53411,"DIRECTION":"BI","MASTER_ID":53408,"compounds":"(1S,4R)-1-hydroxylimonen-2-one + H(+) + NADPH + O2 <=> (4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)","pmd":560.981}
{"X":4793,"KEGG":"R06400","RHEA_ID":53411,"DIRECTION":"BI","MASTER_ID":53408,"compounds":"(1S,4R)-1-hydroxylimonen-2-one + H(+) + NADPH + O2 <=> (4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)","pmd":15.995}
{"X":4794,"KEGG":"R06417","RHEA_ID":25652,"DIRECTION":"BI","MASTER_ID":25649,"compounds":"(2R,5R)-isopulegone + NADP(+) <=> (6R)-isopiperitenone + H(+) + NADPH","pmd":592.971}
{"X":4795,"KEGG":"R06417","RHEA_ID":25652,"DIRECTION":"BI","MASTER_ID":25649,"compounds":"(2R,5R)-isopulegone + NADP(+) <=> (6R)-isopiperitenone + H(+) + NADPH","pmd":2.016}
{"X":4796,"KEGG":"R06419","RHEA_ID":25644,"DIRECTION":"BI","MASTER_ID":25641,"compounds":"(1R,4S)-menthone + NADP(+) <=> (R)-pulegone + H(+) + NADPH","pmd":2.016}
{"X":4797,"KEGG":"R06419","RHEA_ID":25644,"DIRECTION":"BI","MASTER_ID":25641,"compounds":"(1R,4S)-menthone + NADP(+) <=> (R)-pulegone + H(+) + NADPH","pmd":590.955}
{"X":4798,"KEGG":"R06420","RHEA_ID":25648,"DIRECTION":"BI","MASTER_ID":25645,"compounds":"(2R,5R)-isomenthone + NADP(+) <=> (R)-pulegone + H(+) + NADPH","pmd":2.016}
{"X":4799,"KEGG":"R06420","RHEA_ID":25648,"DIRECTION":"BI","MASTER_ID":25645,"compounds":"(2R,5R)-isomenthone + NADP(+) <=> (R)-pulegone + H(+) + NADPH","pmd":590.955}
{"X":4800,"KEGG":"R06421","RHEA_ID":32554,"DIRECTION":"BI","MASTER_ID":32551,"compounds":"(2E)-geranyl diphosphate + H2O <=> (S)-alpha-terpineol + diphosphate","pmd":159.933}
{"X":4801,"KEGG":"R06423","RHEA_ID":31670,"DIRECTION":"BI","MASTER_ID":31667,"metacyc":"RXN-12810","compounds":"2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-glucose <=> dTDP-3-dehydro-6-deoxy-alpha-D-glucose + L-glutamate","pmd":1.032}
{"X":4802,"KEGG":"R06424","RHEA_ID":31842,"DIRECTION":"BI","MASTER_ID":31839,"compounds":"dTDP-4-dehydro-6-deoxy-alpha-D-glucose <=> dTDP-3-dehydro-6-deoxy-alpha-D-glucose","pmd":0}
{"X":4803,"KEGG":"R06426","RHEA_ID":39910,"DIRECTION":"BI","MASTER_ID":39907,"metacyc":"RXN-12768","compounds":"2-oxoglutarate + dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose <=> dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + L-glutamate","pmd":1.032}
{"X":4804,"KEGG":"R06427","RHEA_ID":31762,"DIRECTION":"BI","MASTER_ID":31759,"compounds":"dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine <=> dTDP-alpha-D-desosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine","pmd":14.016}
{"X":4805,"KEGG":"R06427","RHEA_ID":31762,"DIRECTION":"BI","MASTER_ID":31759,"compounds":"dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine <=> dTDP-alpha-D-desosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine","pmd":28.031}
{"X":4806,"KEGG":"R06428","RHEA_ID":47979,"DIRECTION":"BI","MASTER_ID":47976,"compounds":"dTDP-4-dehydro-6-deoxy-alpha-D-glucose <=> dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose + H2O","pmd":18.011}
{"X":4807,"KEGG":"R06437","RHEA_ID":36974,"DIRECTION":"BI","MASTER_ID":36971,"compounds":"dTDP-4-dehydro-6-deoxy-alpha-D-glucose <=> dTDP-4-dehydro-6-deoxy-alpha-D-allose","pmd":0}
{"X":4808,"KEGG":"R06438","RHEA_ID":36682,"DIRECTION":"BI","MASTER_ID":36679,"compounds":"dTDP-6-deoxy-alpha-D-allose + NAD(+) <=> dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADH","pmd":118.052}
{"X":4809,"KEGG":"R06438","RHEA_ID":36682,"DIRECTION":"BI","MASTER_ID":36679,"compounds":"dTDP-6-deoxy-alpha-D-allose + NAD(+) <=> dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADH","pmd":2.016}
{"X":4810,"KEGG":"R06439","RHEA_ID":31674,"DIRECTION":"BI","MASTER_ID":31671,"compounds":"dTDP-3-amino-3,6-dideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine <=> dTDP-alpha-D-mycaminose + 2 H(+) + 2 S-adenosyl-L-homocysteine","pmd":14.016}
{"X":4811,"KEGG":"R06439","RHEA_ID":31674,"DIRECTION":"BI","MASTER_ID":31671,"compounds":"dTDP-3-amino-3,6-dideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine <=> dTDP-alpha-D-mycaminose + 2 H(+) + 2 S-adenosyl-L-homocysteine","pmd":28.031}
{"X":4812,"KEGG":"R06447","RHEA_ID":27554,"DIRECTION":"BI","MASTER_ID":27551,"compounds":"(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate <=> di-trans,octa-cis-undecaprenyl diphosphate + 8 diphosphate","pmd":544.501}
{"X":4813,"KEGG":"R06447","RHEA_ID":27554,"DIRECTION":"BI","MASTER_ID":27551,"compounds":"(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate <=> di-trans,octa-cis-undecaprenyl diphosphate + 8 diphosphate","pmd":680.626}
{"X":4814,"KEGG":"R06450","RHEA_ID":21471,"DIRECTION":"BI","MASTER_ID":21468,"compounds":"dTDP-alpha-D-mycaminose + tylactone <=> 5-O-beta-D-mycaminosyltylactone + dTDP + H(+)","pmd":7.751}
{"X":4815,"KEGG":"R06451","RHEA_ID":15360,"DIRECTION":"BI","MASTER_ID":15357,"compounds":"5-O-beta-D-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose <=> demethyllactenocin + dTDP + H(+)","pmd":146.058}
{"X":4816,"KEGG":"R06452","RHEA_ID":14652,"DIRECTION":"BI","MASTER_ID":14649,"compounds":"demethyllactenocin + dTDP-beta-L-mycarose <=> demethylmacrocin + dTDP + H(+)","pmd":144.079}
{"X":4817,"KEGG":"R06456","RHEA_ID":31626,"DIRECTION":"BI","MASTER_ID":31623,"compounds":"L-olivosyl-oleandolide + S-adenosyl-L-methionine <=> H(+) + L-oleandrosyl-oleandolide + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":4818,"KEGG":"R06458","RHEA_ID":43059,"DIRECTION":"BI","MASTER_ID":43056,"compounds":"5 (S)-methylmalonyl-CoA + 11 H(+) + malonyl-CoA + 5 NADPH <=> 10-deoxymethynolide + 6 CO2 + 6 CoA + 2 H2O + 5 NADP(+)","pmd":100.016}
{"X":4819,"KEGG":"R06458","RHEA_ID":43059,"DIRECTION":"BI","MASTER_ID":43056,"compounds":"5 (S)-methylmalonyl-CoA + 11 H(+) + malonyl-CoA + 5 NADPH <=> 10-deoxymethynolide + 6 CO2 + 6 CoA + 2 H2O + 5 NADP(+)","pmd":22.024}
{"X":4820,"KEGG":"R06458","RHEA_ID":43059,"DIRECTION":"BI","MASTER_ID":43056,"compounds":"5 (S)-methylmalonyl-CoA + 11 H(+) + malonyl-CoA + 5 NADPH <=> 10-deoxymethynolide + 6 CO2 + 6 CoA + 2 H2O + 5 NADP(+)","pmd":86}
{"X":4821,"KEGG":"R06459","RHEA_ID":42847,"DIRECTION":"BI","MASTER_ID":42844,"compounds":"6 (S)-methylmalonyl-CoA + 12 H(+) + malonyl-CoA + 5 NADPH <=> 7 CO2 + 7 CoA + 2 H2O + 5 NADP(+) + narbonolide","pmd":100.016}
{"X":4822,"KEGG":"R06459","RHEA_ID":42847,"DIRECTION":"BI","MASTER_ID":42844,"compounds":"6 (S)-methylmalonyl-CoA + 12 H(+) + malonyl-CoA + 5 NADPH <=> 7 CO2 + 7 CoA + 2 H2O + 5 NADP(+) + narbonolide","pmd":86}
{"X":4823,"KEGG":"R06459","RHEA_ID":42847,"DIRECTION":"BI","MASTER_ID":42844,"compounds":"6 (S)-methylmalonyl-CoA + 12 H(+) + malonyl-CoA + 5 NADPH <=> 7 CO2 + 7 CoA + 2 H2O + 5 NADP(+) + narbonolide","pmd":22.024}
{"X":4824,"KEGG":"R06460","RHEA_ID":31630,"DIRECTION":"BI","MASTER_ID":31627,"compounds":"10-deoxymethynolide + dTDP-alpha-D-desosamine <=> 10-deoxymethymycin + dTDP + H(+)","pmd":105.824}
{"X":4825,"KEGG":"R06462","RHEA_ID":40546,"DIRECTION":"BI","MASTER_ID":40543,"compounds":"10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + neomethymycin + 2 oxidized [2Fe-2S]-[ferredoxin]","pmd":15.995}
{"X":4826,"KEGG":"R06463","RHEA_ID":40542,"DIRECTION":"BI","MASTER_ID":40539,"compounds":"10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + methymycin + 2 oxidized [2Fe-2S]-[ferredoxin]","pmd":15.995}
{"X":4827,"KEGG":"R06464","RHEA_ID":39890,"DIRECTION":"BI","MASTER_ID":39887,"compounds":"2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pikromycin","pmd":15.995}
{"X":4828,"KEGG":"R06466","RHEA_ID":31386,"DIRECTION":"BI","MASTER_ID":31383,"compounds":"(S)-2,3-epoxysqualene <=> lupeol","pmd":0}
{"X":4829,"KEGG":"R06502","RHEA_ID":14892,"DIRECTION":"BI","MASTER_ID":14889,"metacyc":"5.3.3.13-RXN","compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate <=> (5Z,7E,9E,14Z,17Z)-icosapentaenoate","pmd":0}
{"X":4830,"KEGG":"R06513","RHEA_ID":17224,"DIRECTION":"BI","MASTER_ID":17221,"ecocyc":"DTDPGLUCDEHYDRAT-RXN","metacyc":"DTDPGLUCDEHYDRAT-RXN","compounds":"dTDP-alpha-D-glucose <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O","pmd":18.011}
{"X":4831,"KEGG":"R06514","RHEA_ID":16972,"DIRECTION":"BI","MASTER_ID":16969,"ecocyc":"DTDPDEHYDRHAMEPIM-RXN","metacyc":"DTDPDEHYDRHAMEPIM-RXN","compounds":"dTDP-4-dehydro-6-deoxy-alpha-D-glucose <=> dTDP-4-dehydro-beta-L-rhamnose","pmd":0}
{"X":4832,"KEGG":"R06519","RHEA_ID":46547,"DIRECTION":"BI","MASTER_ID":46544,"compounds":"2 [Fe(II)-cytochrome b5] + an N-acylsphinganine + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + an N-acylsphing-4-enine + 2 H2O"}
{"X":4833,"KEGG":"R06520","RHEA_ID":27517,"DIRECTION":"BI","MASTER_ID":27514,"compounds":"H2O + sphinganine 1-phosphate <=> phosphate + sphinganine","pmd":79.966}
{"X":4834,"KEGG":"R06523","RHEA_ID":10343,"DIRECTION":"BI","MASTER_ID":10340,"compounds":"(2E,6E)-farnesyl diphosphate <=> (-)-vetispiradiene + diphosphate","pmd":177.943}
{"X":4835,"KEGG":"R06526","RHEA_ID":46367,"DIRECTION":"BI","MASTER_ID":46364,"compounds":"2 [Fe(II)-cytochrome b5] + an N-acylsphinganine + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + an N-acyl-(4R)-4-hydroxysphinganine + H2O"}
{"X":4836,"KEGG":"R06529","RHEA_ID":21899,"DIRECTION":"BI","MASTER_ID":21896,"compounds":"(R)-1-aminopropan-2-yl phosphate + adenosylcob(III)yrate + ATP <=> adenosylcob(III)inamide phosphate + ADP + H(+) + phosphate","pmd":271.995}
{"X":4837,"KEGG":"R06529","RHEA_ID":21899,"DIRECTION":"BI","MASTER_ID":21896,"compounds":"(R)-1-aminopropan-2-yl phosphate + adenosylcob(III)yrate + ATP <=> adenosylcob(III)inamide phosphate + ADP + H(+) + phosphate","pmd":79.966}
{"X":4838,"KEGG":"R06530","RHEA_ID":11495,"DIRECTION":"BI","MASTER_ID":11492,"compounds":"H(+) + O-phospho-L-threonine <=> (R)-1-aminopropan-2-yl phosphate + CO2","pmd":43.99}
{"X":4839,"KEGG":"R06531","RHEA_ID":33710,"DIRECTION":"BI","MASTER_ID":33707,"compounds":"ATP + L-threonine <=> ADP + H(+) + O-phospho-L-threonine","pmd":79.966}
{"X":4840,"KEGG":"R06532","RHEA_ID":10619,"DIRECTION":"BI","MASTER_ID":10616,"compounds":"(2R,3S)-catechin + H2O + NADP(+) <=> (2R,3S,4S)-leucocyanidin + H(+) + NADPH","pmd":15.995}
{"X":4841,"KEGG":"R06532","RHEA_ID":10619,"DIRECTION":"BI","MASTER_ID":10616,"compounds":"(2R,3S)-catechin + H2O + NADP(+) <=> (2R,3S,4S)-leucocyanidin + H(+) + NADPH","pmd":455.012}
{"X":4842,"KEGG":"R06534","RHEA_ID":61507,"DIRECTION":"BI","MASTER_ID":61504,"compounds":"pelargonidin + UDP-alpha-D-glucose <=> pelargonidin 3-O-beta-D-glucoside + UDP","pmd":132.942}
{"X":4843,"KEGG":"R06534","RHEA_ID":61507,"DIRECTION":"BI","MASTER_ID":61504,"compounds":"pelargonidin + UDP-alpha-D-glucose <=> pelargonidin 3-O-beta-D-glucoside + UDP","pmd":132.941}
{"X":4844,"KEGG":"R06535","RHEA_ID":60103,"DIRECTION":"BI","MASTER_ID":60100,"compounds":"cyanidin + UDP-alpha-D-glucose <=> cyanidin 3-O-beta-D-glucoside + H(+) + UDP","pmd":116.947}
{"X":4845,"KEGG":"R06536","RHEA_ID":61503,"DIRECTION":"BI","MASTER_ID":61500,"compounds":"delphinidin + UDP-alpha-D-glucose <=> delphinidin 3-O-beta-D-glucoside + UDP","pmd":100.952}
{"X":4846,"KEGG":"R06538","RHEA_ID":61127,"DIRECTION":"BI","MASTER_ID":61124,"compounds":"kaempferol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + quercetin","pmd":15.995}
{"X":4847,"KEGG":"R06539","RHEA_ID":61143,"DIRECTION":"BI","MASTER_ID":61140,"compounds":"(2R,3R)-dihydromyricetin + 2-oxoglutarate + O2 <=> CO2 + H(+) + H2O + myricetin + succinate","pmd":27.995}
{"X":4848,"KEGG":"R06539","RHEA_ID":61143,"DIRECTION":"BI","MASTER_ID":61140,"compounds":"(2R,3R)-dihydromyricetin + 2-oxoglutarate + O2 <=> CO2 + H(+) + H2O + myricetin + succinate","pmd":2.016}
{"X":4849,"KEGG":"R06558","RHEA_ID":15768,"DIRECTION":"BI","MASTER_ID":15765,"compounds":"adenosylcob(III)inamide + GTP <=> adenosylcob(III)inamide phosphate + GDP + H(+)","pmd":79.966}
{"X":4850,"KEGG":"R06560","RHEA_ID":12391,"DIRECTION":"BI","MASTER_ID":12388,"compounds":"formononetin + O2 + reduced [NADPH--hemoprotein reductase] <=> 2'-hydroxyformononetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":4851,"KEGG":"R06562","RHEA_ID":22563,"DIRECTION":"BI","MASTER_ID":22560,"compounds":"(3R)-vestitone + NADP(+) <=> 2'-hydroxyformononetin + 2 H(+) + NADPH","pmd":2.016}
{"X":4852,"KEGG":"R06562","RHEA_ID":22563,"DIRECTION":"BI","MASTER_ID":22560,"compounds":"(3R)-vestitone + NADP(+) <=> 2'-hydroxyformononetin + 2 H(+) + NADPH","pmd":459.007}
{"X":4853,"KEGG":"R06568","RHEA_ID":10587,"DIRECTION":"BI","MASTER_ID":10584,"compounds":"4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH <=> 3 CO2 + 4 CoA + H2O + isoliquiritigenin + NADP(+)","pmd":146.037}
{"X":4854,"KEGG":"R06568","RHEA_ID":10587,"DIRECTION":"BI","MASTER_ID":10584,"compounds":"4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH <=> 3 CO2 + 4 CoA + H2O + isoliquiritigenin + NADP(+)","pmd":22.024}
{"X":4855,"KEGG":"R06568","RHEA_ID":10587,"DIRECTION":"BI","MASTER_ID":10584,"compounds":"4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH <=> 3 CO2 + 4 CoA + H2O + isoliquiritigenin + NADP(+)","pmd":86}
{"X":4856,"KEGG":"R06571","RHEA_ID":45731,"DIRECTION":"BI","MASTER_ID":45728,"compounds":"(E)-caffeyl alcohol + NADP(+) <=> (E)-caffeyl aldehyde + H(+) + NADPH","pmd":579.028}
{"X":4857,"KEGG":"R06571","RHEA_ID":45731,"DIRECTION":"BI","MASTER_ID":45728,"compounds":"(E)-caffeyl alcohol + NADP(+) <=> (E)-caffeyl aldehyde + H(+) + NADPH","pmd":2.016}
{"X":4858,"KEGG":"R06588","RHEA_ID":35754,"DIRECTION":"BI","MASTER_ID":35751,"compounds":"ATP + kanosamine <=> ADP + D-kanosamine 6-phosphate + H(+)","pmd":79.966}
{"X":4859,"KEGG":"R06594","RHEA_ID":35758,"DIRECTION":"BI","MASTER_ID":35755,"compounds":"NAD(+) + UDP-alpha-D-glucose <=> H(+) + NADH + UDP-3-oxo-alpha-D-glucose","pmd":2.016}
{"X":4860,"KEGG":"R06594","RHEA_ID":35758,"DIRECTION":"BI","MASTER_ID":35755,"compounds":"NAD(+) + UDP-alpha-D-glucose <=> H(+) + NADH + UDP-3-oxo-alpha-D-glucose","pmd":100.077}
{"X":4861,"KEGG":"R06595","RHEA_ID":35774,"DIRECTION":"BI","MASTER_ID":35771,"compounds":"5-deoxy-5-amino-3-dehydroshikimate <=> 3-amino-5-hydroxybenzoate + H(+) + H2O","pmd":18.011}
{"X":4862,"KEGG":"R06601","RHEA_ID":23739,"DIRECTION":"BI","MASTER_ID":23736,"compounds":"5-hydroxyisourate + H2O <=> 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)","pmd":18.011}
{"X":4863,"KEGG":"R06602","RHEA_ID":27877,"DIRECTION":"BI","MASTER_ID":27874,"compounds":"isochorismate <=> pyruvate + salicylate","pmd":88.016}
{"X":4864,"KEGG":"R06604","RHEA_ID":26304,"DIRECTION":"BI","MASTER_ID":26301,"compounds":"5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+) <=> (S)-allantoin + CO2","pmd":43.99}
{"X":4865,"KEGG":"R06606","RHEA_ID":53211,"DIRECTION":"BI","MASTER_ID":53208,"compounds":"daidzein + O2 + reduced [NADPH--hemoprotein reductase] <=> 2'-hydroxydaidzein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":4866,"KEGG":"R06607","RHEA_ID":56111,"DIRECTION":"BI","MASTER_ID":56108,"compounds":"genistein + O2 + reduced [NADPH--hemoprotein reductase] <=> 2'-hydroxygenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":4867,"KEGG":"R06613","RHEA_ID":29046,"DIRECTION":"BI","MASTER_ID":29043,"compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH <=> (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+)","pmd":14.016}
{"X":4868,"KEGG":"R06613","RHEA_ID":29046,"DIRECTION":"BI","MASTER_ID":29043,"compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH <=> (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+)","pmd":299.92}
{"X":4869,"KEGG":"R06613","RHEA_ID":29046,"DIRECTION":"BI","MASTER_ID":29043,"compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH <=> (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+)","pmd":12}
{"X":4870,"KEGG":"R06620","RHEA_ID":22155,"DIRECTION":"BI","MASTER_ID":22152,"compounds":"a ubiquinone + D-glucose <=> a ubiquinol + D-glucono-1,5-lactone","pmd":2.016}
{"X":4871,"KEGG":"R06624","RHEA_ID":44635,"DIRECTION":"BI","MASTER_ID":44632,"compounds":"(3,5-dihydroxyphenyl)acetyl-CoA + O2 <=> 2-(3,5-dihydroxyphenyl)-2-oxoacetate + CoA + H(+)","pmd":150.032}
{"X":4872,"KEGG":"R06625","RHEA_ID":44747,"DIRECTION":"BI","MASTER_ID":44744,"metacyc":"RXN-16276","compounds":"4 H(+) + 4 malonyl-CoA <=> (3,5-dihydroxyphenyl)acetyl-CoA + 4 CO2 + 3 CoA + H2O","pmd":64.031}
{"X":4873,"KEGG":"R06633","RHEA_ID":41230,"DIRECTION":"BI","MASTER_ID":41227,"metacyc":"RXN-15300","compounds":"(S)-4-hydroxymandelate + O2 <=> 4-hydroxyphenylglyoxylate + H2O2","pmd":2.016}
{"X":4874,"KEGG":"R06634","RHEA_ID":38350,"DIRECTION":"BI","MASTER_ID":38347,"metacyc":"RXN-14845","compounds":"(S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate <=> 2-(3,5-dihydroxyphenyl)-2-oxoacetate + L-glutamate","pmd":1.032}
{"X":4875,"KEGG":"R06680","RHEA_ID":37878,"DIRECTION":"BI","MASTER_ID":37875,"compounds":"aklanonate + S-adenosyl-L-methionine <=> methyl aklanonate + S-adenosyl-L-homocysteine","pmd":11.963}
{"X":4876,"KEGG":"R06681","RHEA_ID":37882,"DIRECTION":"BI","MASTER_ID":37879,"compounds":"methyl aklanonate <=> aklaviketone","pmd":0}
{"X":4877,"KEGG":"R06682","RHEA_ID":37414,"DIRECTION":"BI","MASTER_ID":37411,"compounds":"aklavinone + NADP(+) <=> aklaviketone + 2 H(+) + NADPH","pmd":2.016}
{"X":4878,"KEGG":"R06682","RHEA_ID":37414,"DIRECTION":"BI","MASTER_ID":37411,"compounds":"aklavinone + NADP(+) <=> aklaviketone + 2 H(+) + NADPH","pmd":332.975}
{"X":4879,"KEGG":"R06683","RHEA_ID":37838,"DIRECTION":"BI","MASTER_ID":37835,"compounds":"aklavinone + H(+) + NADPH + O2 <=> epsilon-rhodomycinone + H2O + NADP(+)","pmd":15.995}
{"X":4880,"KEGG":"R06683","RHEA_ID":37838,"DIRECTION":"BI","MASTER_ID":37835,"compounds":"aklavinone + H(+) + NADPH + O2 <=> epsilon-rhodomycinone + H2O + NADP(+)","pmd":316.98}
{"X":4881,"KEGG":"R06684","RHEA_ID":45763,"DIRECTION":"BI","MASTER_ID":45760,"compounds":"dTDP-beta-L-daunosamine + epsilon-rhodomycinone <=> dTDP + H(+) + rhodomycin D","pmd":26.088}
{"X":4882,"KEGG":"R06685","RHEA_ID":40250,"DIRECTION":"BI","MASTER_ID":40247,"compounds":"H2O + rhodomycin D <=> 10-carboxy-13-deoxycarminomycin + H(+) + methanol","pmd":14.016}
{"X":4883,"KEGG":"R06688","RHEA_ID":37854,"DIRECTION":"BI","MASTER_ID":37851,"compounds":"13-deoxydaunorubicin + H(+) + NADPH + O2 <=> 13-dihydrodaunorubicin + H2O + NADP(+)","pmd":215.896}
{"X":4884,"KEGG":"R06688","RHEA_ID":37854,"DIRECTION":"BI","MASTER_ID":37851,"compounds":"13-deoxydaunorubicin + H(+) + NADPH + O2 <=> 13-dihydrodaunorubicin + H2O + NADP(+)","pmd":15.995}
{"X":4885,"KEGG":"R06689","RHEA_ID":37850,"DIRECTION":"BI","MASTER_ID":37847,"compounds":"13-dihydrodaunorubicin + H(+) + NADPH + O2 <=> daunorubicin + 2 H2O + NADP(+)","pmd":217.912}
{"X":4886,"KEGG":"R06689","RHEA_ID":37850,"DIRECTION":"BI","MASTER_ID":37847,"compounds":"13-dihydrodaunorubicin + H(+) + NADPH + O2 <=> daunorubicin + 2 H2O + NADP(+)","pmd":2.016}
{"X":4887,"KEGG":"R06690","RHEA_ID":15720,"DIRECTION":"BI","MASTER_ID":15717,"compounds":"daunorubicin + H(+) + NADPH + O2 <=> doxorubicin + H2O + NADP(+)","pmd":201.917}
{"X":4888,"KEGG":"R06690","RHEA_ID":15720,"DIRECTION":"BI","MASTER_ID":15717,"compounds":"daunorubicin + H(+) + NADPH + O2 <=> doxorubicin + H2O + NADP(+)","pmd":15.995}
{"X":4889,"KEGG":"R06691","RHEA_ID":56363,"DIRECTION":"BI","MASTER_ID":56360,"compounds":"13-deoxycarminomycin + H(+) + NADPH + O2 <=> 13-dihydrocarminomycin + H2O + NADP(+)","pmd":15.995}
{"X":4890,"KEGG":"R06691","RHEA_ID":56363,"DIRECTION":"BI","MASTER_ID":56360,"compounds":"13-deoxycarminomycin + H(+) + NADPH + O2 <=> 13-dihydrocarminomycin + H2O + NADP(+)","pmd":229.912}
{"X":4891,"KEGG":"R06692","RHEA_ID":56367,"DIRECTION":"BI","MASTER_ID":56364,"compounds":"13-dihydrocarminomycin + H(+) + NADPH + O2 <=> carminomycin + 2 H2O + NADP(+)","pmd":231.928}
{"X":4892,"KEGG":"R06692","RHEA_ID":56367,"DIRECTION":"BI","MASTER_ID":56364,"compounds":"13-dihydrocarminomycin + H(+) + NADPH + O2 <=> carminomycin + 2 H2O + NADP(+)","pmd":2.016}
{"X":4893,"KEGG":"R06693","RHEA_ID":38314,"DIRECTION":"BI","MASTER_ID":38311,"metacyc":"RXN-14828","compounds":"carminomycin + S-adenosyl-L-methionine <=> daunorubicin + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":4894,"KEGG":"R06699","RHEA_ID":38854,"DIRECTION":"BI","MASTER_ID":38851,"compounds":"H(+) + tetracenomycin F2 <=> H2O + tetracenomycin F1","pmd":18.01}
{"X":4895,"KEGG":"R06704","RHEA_ID":42823,"DIRECTION":"BI","MASTER_ID":42820,"compounds":"2 H(+) + 2 NADPH + 2 O2 + tetracenomycin A2 <=> H2O + 2 NADP(+) + tetracenomycin C","pmd":272.99}
{"X":4896,"KEGG":"R06704","RHEA_ID":42823,"DIRECTION":"BI","MASTER_ID":42820,"compounds":"2 H(+) + 2 NADPH + 2 O2 + tetracenomycin A2 <=> H2O + 2 NADP(+) + tetracenomycin C","pmd":50}
{"X":4897,"KEGG":"R06704","RHEA_ID":42827,"DIRECTION":"BI","MASTER_ID":42824,"compounds":"2 H(+) + 2 NADH + 2 O2 + tetracenomycin A2 <=> H2O + 2 NAD(+) + tetracenomycin C","pmd":272.99}
{"X":4898,"KEGG":"R06704","RHEA_ID":42827,"DIRECTION":"BI","MASTER_ID":42824,"compounds":"2 H(+) + 2 NADH + 2 O2 + tetracenomycin A2 <=> H2O + 2 NAD(+) + tetracenomycin C","pmd":50}
{"X":4899,"KEGG":"R06722","RHEA_ID":56007,"DIRECTION":"BI","MASTER_ID":56004,"compounds":"H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3)"}
{"X":4900,"KEGG":"R06728","RHEA_ID":27509,"DIRECTION":"BI","MASTER_ID":27506,"compounds":"cocaine + H2O <=> benzoate + ecgonine methyl ester + H(+)","pmd":104.026}
{"X":4901,"KEGG":"R06734","RHEA_ID":24247,"DIRECTION":"BI","MASTER_ID":24244,"compounds":"NADP(+) + pseudotropine <=> H(+) + NADPH + tropinone","pmd":603.976}
{"X":4902,"KEGG":"R06734","RHEA_ID":24247,"DIRECTION":"BI","MASTER_ID":24244,"compounds":"NADP(+) + pseudotropine <=> H(+) + NADPH + tropinone","pmd":2.016}
{"X":4903,"KEGG":"R06741","RHEA_ID":61631,"DIRECTION":"BI","MASTER_ID":61628,"compounds":"5-aminopentanal <=> 1-piperideine + H2O"}
{"X":4904,"KEGG":"R06747","RHEA_ID":55155,"DIRECTION":"BI","MASTER_ID":55152,"compounds":"H(+) + L-prolyl-[peptidyl-carrier protein] + 2 oxidized [electron-transfer flavoprotein] <=> (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 reduced [electron-transfer flavoprotein]"}
{"X":4905,"KEGG":"R06757","RHEA_ID":37058,"DIRECTION":"BI","MASTER_ID":37055,"compounds":"3-(4-hydroxyphenyl)pyruvate + dimethylallyl diphosphate <=> 3-dimethylallyl-4-hydroxyphenylpyruvate + diphosphate","pmd":68.063}
{"X":4906,"KEGG":"R06757","RHEA_ID":37058,"DIRECTION":"BI","MASTER_ID":37055,"compounds":"3-(4-hydroxyphenyl)pyruvate + dimethylallyl diphosphate <=> 3-dimethylallyl-4-hydroxyphenylpyruvate + diphosphate","pmd":2.099}
{"X":4907,"KEGG":"R06758","RHEA_ID":52911,"DIRECTION":"BI","MASTER_ID":52908,"compounds":"3-dimethylallyl-4-hydroxyphenylpyruvate + O2 <=> 3-dimethylallyl-4-hydroxymandelate + CO2","pmd":12}
{"X":4908,"KEGG":"R06759","RHEA_ID":52915,"DIRECTION":"BI","MASTER_ID":52912,"compounds":"3-dimethylallyl-4-hydroxymandelate + O2 <=> 3-dimethylallyl-4-hydroxybenzoate + CO2 + H2O","pmd":30.011}
{"X":4909,"KEGG":"R06770","RHEA_ID":36698,"DIRECTION":"BI","MASTER_ID":36695,"compounds":"dTDP-4-O-demethyl-beta-L-noviose + novobiocic acid <=> desmethyldescarbamoylnovobiocin + dTDP + H(+)","pmd":6.886}
{"X":4910,"KEGG":"R06771","RHEA_ID":36658,"DIRECTION":"BI","MASTER_ID":36655,"compounds":"desmethyldescarbamoylnovobiocin + S-adenosyl-L-methionine <=> descarbamoylnovobiocin + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":4911,"KEGG":"R06772","RHEA_ID":36662,"DIRECTION":"BI","MASTER_ID":36659,"compounds":"carbamoyl phosphate + descarbamoylnovobiocin <=> novobiocin + phosphate","pmd":471.249}
{"X":4912,"KEGG":"R06772","RHEA_ID":36662,"DIRECTION":"BI","MASTER_ID":36659,"compounds":"carbamoyl phosphate + descarbamoylnovobiocin <=> novobiocin + phosphate","pmd":43.006}
{"X":4913,"KEGG":"R06782","RHEA_ID":20360,"DIRECTION":"BI","MASTER_ID":20357,"compounds":"3-phenylpropanoate + H(+) + NADH + O2 <=> 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+)","pmd":34.006}
{"X":4914,"KEGG":"R06782","RHEA_ID":20360,"DIRECTION":"BI","MASTER_ID":20357,"compounds":"3-phenylpropanoate + H(+) + NADH + O2 <=> 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+)","pmd":481.051}
{"X":4915,"KEGG":"R06783","RHEA_ID":25061,"DIRECTION":"BI","MASTER_ID":25058,"compounds":"H(+) + NADH + O2 + trans-cinnamate <=> (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+)","pmd":483.067}
{"X":4916,"KEGG":"R06783","RHEA_ID":25061,"DIRECTION":"BI","MASTER_ID":25058,"compounds":"H(+) + NADH + O2 + trans-cinnamate <=> (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+)","pmd":34.005}
{"X":4917,"KEGG":"R06784","RHEA_ID":25065,"DIRECTION":"BI","MASTER_ID":25062,"compounds":"3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+) <=> 3-(2,3-dihydroxyphenyl)propanoate + H(+) + NADH","pmd":482.059}
{"X":4918,"KEGG":"R06784","RHEA_ID":25065,"DIRECTION":"BI","MASTER_ID":25062,"compounds":"3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+) <=> 3-(2,3-dihydroxyphenyl)propanoate + H(+) + NADH","pmd":2.016}
{"X":4919,"KEGG":"R06785","RHEA_ID":25069,"DIRECTION":"BI","MASTER_ID":25066,"compounds":"(2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+) <=> (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H(+) + NADH","pmd":2.016}
{"X":4920,"KEGG":"R06785","RHEA_ID":25069,"DIRECTION":"BI","MASTER_ID":25066,"compounds":"(2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+) <=> (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H(+) + NADH","pmd":484.075}
{"X":4921,"KEGG":"R06786","RHEA_ID":24788,"DIRECTION":"BI","MASTER_ID":24785,"compounds":"3-(3-hydroxyphenyl)propanoate + H(+) + NADH + O2 <=> 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+)","pmd":483.067}
{"X":4922,"KEGG":"R06786","RHEA_ID":24788,"DIRECTION":"BI","MASTER_ID":24785,"compounds":"3-(3-hydroxyphenyl)propanoate + H(+) + NADH + O2 <=> 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+)","pmd":15.995}
{"X":4923,"KEGG":"R06787","RHEA_ID":27849,"DIRECTION":"BI","MASTER_ID":27846,"compounds":"(2E)-3-(3-hydroxyphenyl)prop-2-enoate + H(+) + NADH + O2 <=> (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD(+)","pmd":15.995}
{"X":4924,"KEGG":"R06787","RHEA_ID":27849,"DIRECTION":"BI","MASTER_ID":27846,"compounds":"(2E)-3-(3-hydroxyphenyl)prop-2-enoate + H(+) + NADH + O2 <=> (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD(+)","pmd":485.083}
{"X":4925,"KEGG":"R06788","RHEA_ID":25057,"DIRECTION":"BI","MASTER_ID":25054,"compounds":"(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O2 <=> (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H(+)","pmd":31.99}
{"X":4926,"KEGG":"R06789","RHEA_ID":25049,"DIRECTION":"BI","MASTER_ID":25046,"compounds":"(2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O <=> (2E)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)","pmd":96.021}
{"X":4927,"KEGG":"R06789","RHEA_ID":34194,"DIRECTION":"BI","MASTER_ID":34191,"compounds":"(2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O <=> (2Z)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)","pmd":96.021}
{"X":4928,"KEGG":"R06792","RHEA_ID":14900,"DIRECTION":"BI","MASTER_ID":14897,"compounds":"apigenin + 3 H(+) + 2 NADPH + O2 <=> 2-hydroxy-2,3-dihydrogenistein + H2O + 2 NADP(+)","pmd":18.011}
{"X":4929,"KEGG":"R06792","RHEA_ID":14900,"DIRECTION":"BI","MASTER_ID":14897,"compounds":"apigenin + 3 H(+) + 2 NADPH + O2 <=> 2-hydroxy-2,3-dihydrogenistein + H2O + 2 NADP(+)","pmd":457.028}
{"X":4930,"KEGG":"R06793","RHEA_ID":36806,"DIRECTION":"BI","MASTER_ID":36803,"compounds":"2-hydroxy-2,3-dihydrogenistein <=> genistein + H(+) + H2O","pmd":18.011}
{"X":4931,"KEGG":"R06795","RHEA_ID":55419,"DIRECTION":"BI","MASTER_ID":55416,"compounds":"biochanin A + UDP-alpha-D-glucose <=> biochanin A 7-O-beta-D-glucoside + H(+) + UDP","pmd":119.934}
{"X":4932,"KEGG":"R06796","RHEA_ID":15584,"DIRECTION":"BI","MASTER_ID":15581,"compounds":"biochanin A 7-O-beta-D-glucoside + malonyl-CoA <=> biochanin A 7-O-beta-D-glucoside 6''-O-malonate + CoA","pmd":86}
{"X":4933,"KEGG":"R06799","RHEA_ID":21991,"DIRECTION":"BI","MASTER_ID":21988,"compounds":"malonyl-CoA + pelargonidin 3-O-(6-O-[(E)-caffeoyl]-beta-D-glucoside) 5-O-beta-D-glucoside <=> 4'''-demalonylsalvianin + CoA","pmd":9.917}
{"X":4934,"KEGG":"R06800","RHEA_ID":35518,"DIRECTION":"BI","MASTER_ID":35515,"compounds":"4'''-demalonylsalvianin + malonyl-CoA <=> CoA + salvianin","pmd":76.083}
{"X":4935,"KEGG":"R06803","RHEA_ID":24864,"DIRECTION":"BI","MASTER_ID":24861,"compounds":"pelargonidin 3-O-rutinoside + UDP-alpha-D-glucose <=> H(+) + pelargonidin 3-O-rutinoside 5-O-beta-D-glucoside + UDP","pmd":162.053}
{"X":4936,"KEGG":"R06807","RHEA_ID":15108,"DIRECTION":"BI","MASTER_ID":15105,"compounds":"kaempferol + S-adenosyl-L-methionine <=> H(+) + kaempferide + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":4937,"KEGG":"R06808","RHEA_ID":15712,"DIRECTION":"BI","MASTER_ID":15709,"metacyc":"2.4.1.234-RXN","compounds":"kaempferol + UDP-alpha-D-galactose <=> H(+) + kaempferol 3-O-beta-D-galactoside + UDP","pmd":117.954}
{"X":4938,"KEGG":"R06812","RHEA_ID":61171,"DIRECTION":"BI","MASTER_ID":61168,"compounds":"quercetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose <=> H(+) + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP","pmd":60.093}
{"X":4939,"KEGG":"R06815","RHEA_ID":25632,"DIRECTION":"BI","MASTER_ID":25629,"compounds":"myricetin + S-adenosyl-L-methionine <=> H(+) + laricitrin + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":4940,"KEGG":"R06816","RHEA_ID":25636,"DIRECTION":"BI","MASTER_ID":25633,"compounds":"laricitrin + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + syringetin","pmd":14.016}
{"X":4941,"KEGG":"R06819","RHEA_ID":12147,"DIRECTION":"BI","MASTER_ID":12144,"metacyc":"2.4.1.116-RXN","compounds":"cyanidin 3-O-rutinoside + UDP-alpha-D-glucose <=> cyanidin 3-O-rutinoside 5-O-beta-D-glucoside + H(+) + UDP","pmd":162.053}
{"X":4942,"KEGG":"R06824","RHEA_ID":11435,"DIRECTION":"BI","MASTER_ID":11432,"compounds":"S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside <=> 7-O-methylvitexin 2''-O-beta-L-rhamnoside + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":4943,"KEGG":"R06827","RHEA_ID":14152,"DIRECTION":"BI","MASTER_ID":14149,"compounds":"luteolin 7-O-beta-D-glucuronide + UDP-alpha-D-glucuronate <=> H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP","pmd":58.078}
{"X":4944,"KEGG":"R06828","RHEA_ID":22119,"DIRECTION":"BI","MASTER_ID":22116,"compounds":"luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP-alpha-D-glucuronate <=> H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] 4'-O-beta-D-glucuronide + UDP","pmd":176.032}
{"X":4945,"KEGG":"R06830","RHEA_ID":43627,"DIRECTION":"BI","MASTER_ID":43624,"compounds":"2-aminomalonate semialdehyde + H(+) <=> aminoacetaldehyde + CO2"}
{"X":4946,"KEGG":"R06833","RHEA_ID":51883,"DIRECTION":"BI","MASTER_ID":51880,"compounds":"3,4,6-trichlorocatechol + O2 <=> (2Z,4E)-2,3,5-trichloromuconate + H(+)","pmd":31.99}
{"X":4947,"KEGG":"R06836","RHEA_ID":20112,"DIRECTION":"BI","MASTER_ID":20109,"ecocyc":"RXN0-1401","compounds":"alpha-D-ribose 1,5-bisphosphate + ATP <=> 5-phospho-alpha-D-ribose 1-diphosphate + ADP","pmd":79.966}
{"X":4948,"KEGG":"R06839","RHEA_ID":48571,"DIRECTION":"BI","MASTER_ID":48568,"compounds":"3-chlorocatechol + O2 <=> (2E,4Z)-2-chloromuconate + 2 H(+)","pmd":31.99}
{"X":4949,"KEGG":"R06845","RHEA_ID":28601,"DIRECTION":"BI","MASTER_ID":28598,"metacyc":"RXN-5185","compounds":"H2O + N-acetyl-L-lysine <=> acetate + L-lysine"}
{"X":4950,"KEGG":"R06846","RHEA_ID":18428,"DIRECTION":"BI","MASTER_ID":18425,"compounds":"L-quinate + NADP(+) <=> 3-dehydroquinate + H(+) + NADPH","pmd":2.016}
{"X":4951,"KEGG":"R06846","RHEA_ID":18428,"DIRECTION":"BI","MASTER_ID":18425,"compounds":"L-quinate + NADP(+) <=> 3-dehydroquinate + H(+) + NADPH","pmd":554.036}
{"X":4952,"KEGG":"R06847","RHEA_ID":17744,"DIRECTION":"BI","MASTER_ID":17741,"compounds":"NAD(+) + shikimate <=> 3-dehydroshikimate + H(+) + NADH","pmd":2.016}
{"X":4953,"KEGG":"R06847","RHEA_ID":17744,"DIRECTION":"BI","MASTER_ID":17741,"compounds":"NAD(+) + shikimate <=> 3-dehydroshikimate + H(+) + NADH","pmd":492.08}
{"X":4954,"KEGG":"R06856","RHEA_ID":57515,"DIRECTION":"BI","MASTER_ID":57512,"compounds":"chlorobenzene + H(+) + NADH + O2 <=> (1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+)","pmd":34.005}
{"X":4955,"KEGG":"R06856","RHEA_ID":57515,"DIRECTION":"BI","MASTER_ID":57512,"compounds":"chlorobenzene + H(+) + NADH + O2 <=> (1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+)","pmd":519.111}
{"X":4956,"KEGG":"R06857","RHEA_ID":57611,"DIRECTION":"BI","MASTER_ID":57608,"compounds":"(1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+) <=> 3-chlorocatechol + H(+) + NADH","pmd":2.016}
{"X":4957,"KEGG":"R06857","RHEA_ID":57611,"DIRECTION":"BI","MASTER_ID":57608,"compounds":"(1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+) <=> 3-chlorocatechol + H(+) + NADH","pmd":520.119}
{"X":4958,"KEGG":"R06858","RHEA_ID":47743,"DIRECTION":"BI","MASTER_ID":47740,"compounds":"1,4-dioxo-2-naphthoate + H(+) + phytyl diphosphate <=> CO2 + demethylphylloquinone + diphosphate"}
{"X":4959,"KEGG":"R06866","RHEA_ID":44771,"DIRECTION":"BI","MASTER_ID":44768,"compounds":"3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) <=> 2-methoxy-6-(all-trans-hexaprenyl)phenol + CO2","pmd":43.99}
{"X":4960,"KEGG":"R06867","RHEA_ID":49471,"DIRECTION":"BI","MASTER_ID":49468,"compounds":"a 1,2-diacyl-sn-glycerol + UDP-alpha-D-6-sulfoquinovose <=> a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H(+) + UDP","pmd":226.015}
{"X":4961,"KEGG":"R06868","RHEA_ID":25324,"DIRECTION":"BI","MASTER_ID":25321,"compounds":"N-methylethanolamine phosphate + S-adenosyl-L-methionine <=> H(+) + N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":4962,"KEGG":"R06869","RHEA_ID":25328,"DIRECTION":"BI","MASTER_ID":25325,"compounds":"N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine <=> H(+) + phosphocholine + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":4963,"KEGG":"R06869","RHEA_ID":25328,"DIRECTION":"BI","MASTER_ID":25325,"compounds":"N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine <=> H(+) + phosphocholine + S-adenosyl-L-homocysteine","pmd":15.024}
{"X":4964,"KEGG":"R06870","RHEA_ID":16092,"DIRECTION":"BI","MASTER_ID":16089,"compounds":"H2O + phosphoethanolamine <=> ethanolamine + phosphate"}
{"X":4965,"KEGG":"R06871","RHEA_ID":10495,"DIRECTION":"BI","MASTER_ID":10492,"compounds":"H2O + phosphocholine <=> choline + phosphate","pmd":79.966}
{"X":4966,"KEGG":"R06872","RHEA_ID":33562,"DIRECTION":"BI","MASTER_ID":33559,"metacyc":"RXN-13112","compounds":"an acyl-CoA + sn-glycerol 3-phosphate <=> a 2-acyl-sn-glycerol 3-phosphate + CoA","pmd":595.101}
{"X":4967,"KEGG":"R06884","RHEA_ID":31570,"DIRECTION":"BI","MASTER_ID":31567,"compounds":"bisphenol A + H(+) + NADH + O2 <=> 2,2-bis(4-hydroxyphenyl)-1-propanol + H2O + NAD(+)","pmd":421.015}
{"X":4968,"KEGG":"R06884","RHEA_ID":31570,"DIRECTION":"BI","MASTER_ID":31567,"compounds":"bisphenol A + H(+) + NADH + O2 <=> 2,2-bis(4-hydroxyphenyl)-1-propanol + H2O + NAD(+)","pmd":15.995}
{"X":4969,"KEGG":"R06892","RHEA_ID":22919,"DIRECTION":"BI","MASTER_ID":22916,"compounds":"4'-hydroxyacetophenone + H(+) + NADPH + O2 <=> 4-acetoxyphenol + H2O + NADP(+)","pmd":593.044}
{"X":4970,"KEGG":"R06892","RHEA_ID":22919,"DIRECTION":"BI","MASTER_ID":22916,"compounds":"4'-hydroxyacetophenone + H(+) + NADPH + O2 <=> 4-acetoxyphenol + H2O + NADP(+)","pmd":15.995}
{"X":4971,"KEGG":"R06895","RHEA_ID":15428,"DIRECTION":"BI","MASTER_ID":15425,"compounds":"coproporphyrinogen III + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + 2 CO2 + 2 L-methionine + protoporphyrinogen IX","pmd":147.035}
{"X":4972,"KEGG":"R06895","RHEA_ID":15428,"DIRECTION":"BI","MASTER_ID":15425,"compounds":"coproporphyrinogen III + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + 2 CO2 + 2 L-methionine + protoporphyrinogen IX","pmd":92.011}
{"X":4973,"KEGG":"R06896","RHEA_ID":48887,"DIRECTION":"BI","MASTER_ID":48884,"metacyc":"RXN1F-72","compounds":"NADP(+) + protochlorophyllide a <=> 3,8-divinyl protochlorophyllide a + H(+) + NADPH","pmd":132.869}
{"X":4974,"KEGG":"R06896","RHEA_ID":48887,"DIRECTION":"BI","MASTER_ID":48884,"metacyc":"RXN1F-72","compounds":"NADP(+) + protochlorophyllide a <=> 3,8-divinyl protochlorophyllide a + H(+) + NADPH","pmd":2.016}
{"X":4975,"KEGG":"R06897","RHEA_ID":42075,"DIRECTION":"BI","MASTER_ID":42072,"compounds":"(4Z)-2-oxohept-4-enedioate + H2O <=> (4S)-4-hydroxy-2-oxoheptanedioate","pmd":18.01}
{"X":4976,"KEGG":"R06941","RHEA_ID":34854,"DIRECTION":"BI","MASTER_ID":34851,"ecocyc":"RXN0-2044","metacyc":"RXN0-2044","compounds":"(3S)-3-hydroxyadipyl-CoA + NAD(+) <=> 3-oxoadipyl-CoA + H(+) + NADH","pmd":245.025}
{"X":4977,"KEGG":"R06941","RHEA_ID":34854,"DIRECTION":"BI","MASTER_ID":34851,"ecocyc":"RXN0-2044","metacyc":"RXN0-2044","compounds":"(3S)-3-hydroxyadipyl-CoA + NAD(+) <=> 3-oxoadipyl-CoA + H(+) + NADH","pmd":2.016}
{"X":4978,"KEGG":"R06948","RHEA_ID":10131,"DIRECTION":"BI","MASTER_ID":10128,"compounds":"all-trans-violaxanthin <=> all-trans-neoxanthin","pmd":0}
{"X":4979,"KEGG":"R06952","RHEA_ID":19680,"DIRECTION":"BI","MASTER_ID":19677,"compounds":"9'-cis-neoxanthin + O2 <=> (3S,5R,6R)-3,5-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin","pmd":218.167}
{"X":4980,"KEGG":"R06953","RHEA_ID":16544,"DIRECTION":"BI","MASTER_ID":16541,"compounds":"9-cis-violaxanthin + O2 <=> (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin","pmd":218.167}
{"X":4981,"KEGG":"R06954","RHEA_ID":12551,"DIRECTION":"BI","MASTER_ID":12548,"compounds":"2-cis,4-trans-xanthoxin + NAD(+) <=> 2-cis-(+)-abscisic aldehyde + H(+) + NADH","pmd":415.976}
{"X":4982,"KEGG":"R06954","RHEA_ID":12551,"DIRECTION":"BI","MASTER_ID":12548,"compounds":"2-cis,4-trans-xanthoxin + NAD(+) <=> 2-cis-(+)-abscisic aldehyde + H(+) + NADH","pmd":2.016}
{"X":4983,"KEGG":"R06957","RHEA_ID":20532,"DIRECTION":"BI","MASTER_ID":20529,"compounds":"2-cis-(+)-abscisic aldehyde + H2O + O2 <=> 2-cis-(+)-abscisate + H(+) + H2O2","pmd":15.995}
{"X":4984,"KEGG":"R06963","RHEA_ID":53127,"DIRECTION":"BI","MASTER_ID":53124,"compounds":"all-trans-lycopene <=> delta-carotene","pmd":0}
{"X":4985,"KEGG":"R06968","RHEA_ID":26200,"DIRECTION":"BI","MASTER_ID":26197,"compounds":"H2O + melamine <=> ammeline + NH4(+)","pmd":0.984}
{"X":4986,"KEGG":"R06969","RHEA_ID":26204,"DIRECTION":"BI","MASTER_ID":26201,"compounds":"ammeline + H(+) + H2O <=> ammelide + NH4(+)","pmd":0.984}
{"X":4987,"KEGG":"R06973","RHEA_ID":45163,"DIRECTION":"BI","MASTER_ID":45160,"compounds":"3-oxopropanoate + H(+) <=> acetaldehyde + CO2"}
{"X":4988,"KEGG":"R06974","RHEA_ID":24832,"DIRECTION":"BI","MASTER_ID":24829,"compounds":"ATP + formate + N(1)-(5-phospho-D-ribosyl)glycinamide <=> ADP + H(+) + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + phosphate","pmd":27.995}
{"X":4989,"KEGG":"R06974","RHEA_ID":24832,"DIRECTION":"BI","MASTER_ID":24829,"compounds":"ATP + formate + N(1)-(5-phospho-D-ribosyl)glycinamide <=> ADP + H(+) + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + phosphate","pmd":79.966}
{"X":4990,"KEGG":"R06975","RHEA_ID":24839,"DIRECTION":"BI","MASTER_ID":24836,"metacyc":"RXN-10066","compounds":"5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + ATP + formate <=> 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + ADP + phosphate","pmd":79.966}
{"X":4991,"KEGG":"R06975","RHEA_ID":24839,"DIRECTION":"BI","MASTER_ID":24836,"metacyc":"RXN-10066","compounds":"5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + ATP + formate <=> 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + ADP + phosphate","pmd":27.995}
{"X":4992,"KEGG":"R06976","RHEA_ID":23295,"DIRECTION":"BI","MASTER_ID":23292,"metacyc":"LOMBRICINE-KINASE-RXN","compounds":"ATP + L-lombricine <=> ADP + H(+) + N-phospho-L-lombricine","pmd":79.966}
{"X":4993,"KEGG":"R06977","RHEA_ID":11163,"DIRECTION":"BI","MASTER_ID":11160,"metacyc":"R101-RXN","compounds":"2-oxoglutarate + L-2,4-diaminobutanoate <=> L-aspartate 4-semialdehyde + L-glutamate","pmd":1.032}
{"X":4994,"KEGG":"R06978","RHEA_ID":16904,"DIRECTION":"BI","MASTER_ID":16901,"metacyc":"R102-RXN","compounds":"acetyl-CoA + L-2,4-diaminobutanoate <=> (2S)-4-acetamido-2-aminobutanoate + CoA + H(+)","pmd":42.011}
{"X":4995,"KEGG":"R06979","RHEA_ID":17284,"DIRECTION":"BI","MASTER_ID":17281,"metacyc":"R103-RXN","compounds":"(2S)-4-acetamido-2-aminobutanoate <=> H2O + L-ectoine","pmd":18.011}
{"X":4996,"KEGG":"R06980","RHEA_ID":25640,"DIRECTION":"BI","MASTER_ID":25637,"metacyc":"RXN-9592","compounds":"H2O + NAD(+) + sulfoacetaldehyde <=> 2 H(+) + NADH + sulfoacetate","pmd":15.995}
{"X":4997,"KEGG":"R06980","RHEA_ID":25640,"DIRECTION":"BI","MASTER_ID":25637,"metacyc":"RXN-9592","compounds":"H2O + NAD(+) + sulfoacetaldehyde <=> 2 H(+) + NADH + sulfoacetate","pmd":524.139}
{"X":4998,"KEGG":"R06982","RHEA_ID":22491,"DIRECTION":"BI","MASTER_ID":22488,"compounds":"S-(hydroxymethyl)glutathione <=> formaldehyde + glutathione","pmd":30.011}
{"X":4999,"KEGG":"R06983","RHEA_ID":19988,"DIRECTION":"BI","MASTER_ID":19985,"compounds":"NAD(+) + S-(hydroxymethyl)glutathione <=> H(+) + NADH + S-formylglutathione","pmd":329.038}
{"X":5000,"KEGG":"R06983","RHEA_ID":19988,"DIRECTION":"BI","MASTER_ID":19985,"compounds":"NAD(+) + S-(hydroxymethyl)glutathione <=> H(+) + NADH + S-formylglutathione","pmd":2.016}
{"X":5001,"KEGG":"R06987","RHEA_ID":28057,"DIRECTION":"BI","MASTER_ID":28054,"compounds":"2-oxobutanoate + CoA <=> formate + propanoyl-CoA","pmd":56.026}
{"X":5002,"KEGG":"R06987","RHEA_ID":28057,"DIRECTION":"BI","MASTER_ID":28054,"compounds":"2-oxobutanoate + CoA <=> formate + propanoyl-CoA","pmd":721.11}
{"X":5003,"KEGG":"R06988","RHEA_ID":20580,"DIRECTION":"BI","MASTER_ID":20577,"metacyc":"5.4.4.3-RXN","compounds":"3-hydroxyaminophenol <=> aminohydroquinone","pmd":0}
{"X":5004,"KEGG":"R06989","RHEA_ID":30034,"DIRECTION":"BI","MASTER_ID":30031,"compounds":"(S)-muconolactone <=> cis,cis-muconate + H(+)","pmd":0}
{"X":5005,"KEGG":"R06990","RHEA_ID":12351,"DIRECTION":"BI","MASTER_ID":12348,"compounds":"(S)-muconolactone <=> (4,5-dihydro-5-oxofuran-2-yl)-acetate","pmd":0}
{"X":5006,"KEGG":"R06998","RHEA_ID":44743,"DIRECTION":"BI","MASTER_ID":44740,"compounds":"27-O-demethylrifamycin SV + S-adenosyl-L-methionine <=> H(+) + rifamycin SV + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5007,"KEGG":"R07053","RHEA_ID":38678,"DIRECTION":"BI","MASTER_ID":38675,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate","pmd":31.99}
{"X":5008,"KEGG":"R07057","RHEA_ID":30294,"DIRECTION":"BI","MASTER_ID":30291,"compounds":"(9Z,12Z)-octadecadienoate + O2 <=> (9S)-hydroperoxy-(10E,12Z)-octadecadienoate","pmd":31.99}
{"X":5009,"KEGG":"R07061","RHEA_ID":25398,"DIRECTION":"BI","MASTER_ID":25395,"compounds":"(9Z,12Z)-octadecadienoate + O2 <=> (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate","pmd":31.99}
{"X":5010,"KEGG":"R07061","RHEA_ID":22395,"DIRECTION":"BI","MASTER_ID":22392,"metacyc":"1.13.11.44-RXN","compounds":"(9Z,12Z)-octadecadienoate + O2 <=> (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate","pmd":31.99}
{"X":5011,"KEGG":"R07062","RHEA_ID":25402,"DIRECTION":"BI","MASTER_ID":25399,"metacyc":"RXN-12758","compounds":"(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate <=> (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate","pmd":0}
{"X":5012,"KEGG":"R07108","RHEA_ID":44043,"DIRECTION":"BI","MASTER_ID":44040,"compounds":"14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O <=> 14,15-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate","pmd":18.011}
{"X":5013,"KEGG":"R07109","RHEA_ID":44047,"DIRECTION":"BI","MASTER_ID":44044,"compounds":"11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O <=> 11,12-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate","pmd":18.011}
{"X":5014,"KEGG":"R07110","RHEA_ID":44051,"DIRECTION":"BI","MASTER_ID":44048,"compounds":"8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O <=> 8,9-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate","pmd":18.011}
{"X":5015,"KEGG":"R07125","RHEA_ID":14356,"DIRECTION":"BI","MASTER_ID":14353,"compounds":"3-dehydro-L-gulonate 6-phosphate + H(+) <=> CO2 + L-xylulose 5-phosphate","pmd":43.99}
{"X":5016,"KEGG":"R07128","RHEA_ID":20420,"DIRECTION":"BI","MASTER_ID":20417,"compounds":"coelenterazine + O2 <=> CO2 + coelenteramide + hnu","pmd":12}
{"X":5017,"KEGG":"R07132","RHEA_ID":18628,"DIRECTION":"BI","MASTER_ID":18625,"metacyc":"RXN-14234","compounds":"D-galactose + NADP(+) <=> D-galactono-1,5-lactone + H(+) + NADPH"}
{"X":5018,"KEGG":"R07132","RHEA_ID":18628,"DIRECTION":"BI","MASTER_ID":18625,"metacyc":"GALACTOSE-1-DEHYDROGENASE-NADP%2b-RXN","compounds":"D-galactose + NADP(+) <=> D-galactono-1,5-lactone + H(+) + NADPH"}
{"X":5019,"KEGG":"R07133","RHEA_ID":19840,"DIRECTION":"BI","MASTER_ID":19837,"ecocyc":"SORB6PDEHYDROG-RXN","metacyc":"SORB6PDEHYDROG-RXN","compounds":"D-sorbitol 6-phosphate + NAD(+) <=> beta-D-fructose 6-phosphate + H(+) + NADH","pmd":404.087}
{"X":5020,"KEGG":"R07133","RHEA_ID":19840,"DIRECTION":"BI","MASTER_ID":19837,"ecocyc":"SORB6PDEHYDROG-RXN","metacyc":"SORB6PDEHYDROG-RXN","compounds":"D-sorbitol 6-phosphate + NAD(+) <=> beta-D-fructose 6-phosphate + H(+) + NADH","pmd":2.016}
{"X":5021,"KEGG":"R07134","RHEA_ID":17392,"DIRECTION":"BI","MASTER_ID":17389,"metacyc":"1.1.1.250-RXN","compounds":"D-arabinitol + NAD(+) <=> D-ribulose + H(+) + NADH","pmd":2.016}
{"X":5022,"KEGG":"R07134","RHEA_ID":17392,"DIRECTION":"BI","MASTER_ID":17389,"metacyc":"1.1.1.250-RXN","compounds":"D-arabinitol + NAD(+) <=> D-ribulose + H(+) + NADH","pmd":514.064}
{"X":5023,"KEGG":"R07135","RHEA_ID":15032,"DIRECTION":"BI","MASTER_ID":15029,"metacyc":"1.1.1.255-RXN","compounds":"D-mannitol + NAD(+) <=> D-mannose + H(+) + NADH","pmd":484.053}
{"X":5024,"KEGG":"R07135","RHEA_ID":15032,"DIRECTION":"BI","MASTER_ID":15029,"metacyc":"1.1.1.255-RXN","compounds":"D-mannitol + NAD(+) <=> D-mannose + H(+) + NADH","pmd":2.016}
{"X":5025,"KEGG":"R07136","RHEA_ID":15536,"DIRECTION":"BI","MASTER_ID":15533,"metacyc":"R230-RXN","compounds":"(R)-3-sulfolactate + NAD(+) <=> 3-sulfopyruvate + H(+) + NADH","pmd":496.144}
{"X":5026,"KEGG":"R07136","RHEA_ID":15536,"DIRECTION":"BI","MASTER_ID":15533,"metacyc":"R230-RXN","compounds":"(R)-3-sulfolactate + NAD(+) <=> 3-sulfopyruvate + H(+) + NADH","pmd":2.016}
{"X":5027,"KEGG":"R07137","RHEA_ID":15540,"DIRECTION":"BI","MASTER_ID":15537,"metacyc":"RXN-11690","compounds":"(R)-3-sulfolactate + NADP(+) <=> 3-sulfopyruvate + H(+) + NADPH","pmd":576.11}
{"X":5028,"KEGG":"R07137","RHEA_ID":15540,"DIRECTION":"BI","MASTER_ID":15537,"metacyc":"RXN-11690","compounds":"(R)-3-sulfolactate + NADP(+) <=> 3-sulfopyruvate + H(+) + NADPH","pmd":2.016}
{"X":5029,"KEGG":"R07138","RHEA_ID":18140,"DIRECTION":"BI","MASTER_ID":18137,"compounds":"3beta-hydroxy-5alpha-pregnane-20-one + NADP(+) <=> 5alpha-pregnane-3,20-dione + H(+) + NADPH","pmd":2.016}
{"X":5030,"KEGG":"R07138","RHEA_ID":18140,"DIRECTION":"BI","MASTER_ID":18137,"compounds":"3beta-hydroxy-5alpha-pregnane-20-one + NADP(+) <=> 5alpha-pregnane-3,20-dione + H(+) + NADPH","pmd":427.843}
{"X":5031,"KEGG":"R07139","RHEA_ID":21751,"DIRECTION":"BI","MASTER_ID":21748,"compounds":"(S)-lactaldehyde + NADP(+) <=> H(+) + methylglyoxal + NADPH"}
{"X":5032,"KEGG":"R07140","RHEA_ID":19984,"DIRECTION":"BI","MASTER_ID":19981,"compounds":"NADP(+) + S-(hydroxymethyl)glutathione <=> H(+) + NADPH + S-formylglutathione","pmd":2.016}
{"X":5033,"KEGG":"R07140","RHEA_ID":19984,"DIRECTION":"BI","MASTER_ID":19981,"compounds":"NADP(+) + S-(hydroxymethyl)glutathione <=> H(+) + NADPH + S-formylglutathione","pmd":409.005}
{"X":5034,"KEGG":"R07141","RHEA_ID":16144,"DIRECTION":"BI","MASTER_ID":16141,"compounds":"2'-deoxymugineate + NAD(+) <=> 3''-deamino-3''-oxonicotianamine + H(+) + NADH","pmd":362.005}
{"X":5035,"KEGG":"R07141","RHEA_ID":16144,"DIRECTION":"BI","MASTER_ID":16141,"compounds":"2'-deoxymugineate + NAD(+) <=> 3''-deamino-3''-oxonicotianamine + H(+) + NADH","pmd":2.016}
{"X":5036,"KEGG":"R07142","RHEA_ID":16140,"DIRECTION":"BI","MASTER_ID":16137,"compounds":"2'-deoxymugineate + NADP(+) <=> 3''-deamino-3''-oxonicotianamine + H(+) + NADPH","pmd":441.972}
{"X":5037,"KEGG":"R07142","RHEA_ID":16140,"DIRECTION":"BI","MASTER_ID":16137,"compounds":"2'-deoxymugineate + NADP(+) <=> 3''-deamino-3''-oxonicotianamine + H(+) + NADPH","pmd":2.016}
{"X":5038,"KEGG":"R07143","RHEA_ID":21279,"DIRECTION":"BI","MASTER_ID":21276,"metacyc":"RXN-7971","compounds":"D-arabinitol + NADP(+) <=> D-xylulose + H(+) + NADPH","pmd":594.031}
{"X":5039,"KEGG":"R07143","RHEA_ID":21279,"DIRECTION":"BI","MASTER_ID":21276,"metacyc":"RXN-7971","compounds":"D-arabinitol + NADP(+) <=> D-xylulose + H(+) + NADPH","pmd":2.016}
{"X":5040,"KEGG":"R07144","RHEA_ID":11871,"DIRECTION":"BI","MASTER_ID":11868,"metacyc":"RXN-7972","compounds":"D-arabinitol + NADP(+) <=> D-ribulose + H(+) + NADPH","pmd":594.031}
{"X":5041,"KEGG":"R07144","RHEA_ID":11871,"DIRECTION":"BI","MASTER_ID":11868,"metacyc":"RXN-7972","compounds":"D-arabinitol + NADP(+) <=> D-ribulose + H(+) + NADPH","pmd":2.016}
{"X":5042,"KEGG":"R07145","RHEA_ID":10163,"DIRECTION":"BI","MASTER_ID":10160,"metacyc":"L-IDITOL-2-DEHYDROGENASE-RXN","compounds":"L-iditol + NAD(+) <=> H(+) + keto-L-sorbose + NADH","pmd":484.053}
{"X":5043,"KEGG":"R07145","RHEA_ID":10163,"DIRECTION":"BI","MASTER_ID":10160,"metacyc":"L-IDITOL-2-DEHYDROGENASE-RXN","compounds":"L-iditol + NAD(+) <=> H(+) + keto-L-sorbose + NADH","pmd":2.016}
{"X":5044,"KEGG":"R07146","RHEA_ID":13604,"DIRECTION":"BI","MASTER_ID":13601,"compounds":"4-hydroxy-L-proline + NAD(+) <=> 4-oxo-L-proline + H(+) + NADH"}
{"X":5045,"KEGG":"R07147","RHEA_ID":14408,"DIRECTION":"BI","MASTER_ID":14405,"metacyc":"GLUCOSE-1-DEHYDROGENASE-RXN","compounds":"D-glucose + NADP(+) <=> D-glucono-1,5-lactone + H(+) + NADPH","pmd":2.016}
{"X":5046,"KEGG":"R07147","RHEA_ID":14408,"DIRECTION":"BI","MASTER_ID":14405,"metacyc":"GLUCOSE-1-DEHYDROGENASE-RXN","compounds":"D-glucose + NADP(+) <=> D-glucono-1,5-lactone + H(+) + NADPH","pmd":566.036}
{"X":5047,"KEGG":"R07148","RHEA_ID":19648,"DIRECTION":"BI","MASTER_ID":19645,"metacyc":"D-THREO-ALDOSE-1-DEHYDROGENASE-RXN","compounds":"a D-threo-aldose + NAD(+) <=> a D-threo-aldono-1,5-lactone + H(+) + NADH"}
{"X":5048,"KEGG":"R07149","RHEA_ID":34774,"DIRECTION":"BI","MASTER_ID":34771,"metacyc":"RXN-13926","compounds":"a 3beta-hydroxysteroid-4alpha-carboxylate + NADP(+) <=> a 3-oxosteroid + CO2 + NADPH","pmd":345.728}
{"X":5049,"KEGG":"R07149","RHEA_ID":34774,"DIRECTION":"BI","MASTER_ID":34771,"metacyc":"RXN-13926","compounds":"a 3beta-hydroxysteroid-4alpha-carboxylate + NADP(+) <=> a 3-oxosteroid + CO2 + NADPH","pmd":46.005}
{"X":5050,"KEGG":"R07149","RHEA_ID":20676,"DIRECTION":"BI","MASTER_ID":20673,"compounds":"3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate + NADP(+) <=> 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADPH","pmd":345.728}
{"X":5051,"KEGG":"R07149","RHEA_ID":20676,"DIRECTION":"BI","MASTER_ID":20673,"compounds":"3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate + NADP(+) <=> 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADPH","pmd":46.005}
{"X":5052,"KEGG":"R07150","RHEA_ID":12399,"DIRECTION":"BI","MASTER_ID":12396,"compounds":"dTDP-D-galactose + H2O + 2 NADP(+) <=> dTDP-D-galacturonate + 3 H(+) + 2 NADPH","pmd":13.979}
{"X":5053,"KEGG":"R07150","RHEA_ID":12399,"DIRECTION":"BI","MASTER_ID":12396,"compounds":"dTDP-D-galactose + H2O + 2 NADP(+) <=> dTDP-D-galacturonate + 3 H(+) + 2 NADPH","pmd":166.028}
{"X":5054,"KEGG":"R07151","RHEA_ID":21683,"DIRECTION":"BI","MASTER_ID":21680,"compounds":"(2S)-2-hydroxyphytanate + O2 <=> 2-oxophytanate + H2O2","pmd":2.016}
{"X":5055,"KEGG":"R07152","RHEA_ID":22311,"DIRECTION":"BI","MASTER_ID":22308,"compounds":"O2 + xylitol <=> D-xylose + H2O2","pmd":2.016}
{"X":5056,"KEGG":"R07152","RHEA_ID":25911,"DIRECTION":"BI","MASTER_ID":25908,"compounds":"an alditol + O2 <=> an aldose + H2O2","pmd":2.016}
{"X":5057,"KEGG":"R07153","RHEA_ID":12371,"DIRECTION":"BI","MASTER_ID":12368,"compounds":"2-dehydro-D-gluconate + A <=> 2,5-didehydro-D-gluconate + AH2","pmd":2.016}
{"X":5058,"KEGG":"R07154","RHEA_ID":14500,"DIRECTION":"BI","MASTER_ID":14497,"compounds":"A + pyridoxine <=> AH2 + isopyridoxal","pmd":2.016}
{"X":5059,"KEGG":"R07155","RHEA_ID":23667,"DIRECTION":"BI","MASTER_ID":23664,"metacyc":"1.1.99.30-RXN","compounds":"A + a (2R)-2-hydroxycarboxylate <=> a 2-oxocarboxylate + AH2"}
{"X":5060,"KEGG":"R07156","RHEA_ID":16680,"DIRECTION":"BI","MASTER_ID":16677,"compounds":"fluoroacetaldehyde + H2O + NAD(+) <=> fluoroacetate + 2 H(+) + NADH"}
{"X":5061,"KEGG":"R07157","RHEA_ID":21043,"DIRECTION":"BI","MASTER_ID":21040,"metacyc":"1.2.7.4-RXN","compounds":"CO + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> CO2 + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":5062,"KEGG":"R07158","RHEA_ID":16424,"DIRECTION":"BI","MASTER_ID":16421,"compounds":"an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":5063,"KEGG":"R07159","RHEA_ID":24151,"DIRECTION":"BI","MASTER_ID":24148,"metacyc":"1.2.7.6-RXN","compounds":"D-glyceraldehyde 3-phosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> (2R)-3-phosphoglycerate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]","pmd":15.995}
{"X":5064,"KEGG":"R07160","RHEA_ID":11715,"DIRECTION":"BI","MASTER_ID":11712,"metacyc":"1.2.7.7-RXN","compounds":"3-methyl-2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2-methylpropanoyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]","pmd":70.042}
{"X":5065,"KEGG":"R07160","RHEA_ID":11715,"DIRECTION":"BI","MASTER_ID":11712,"metacyc":"1.2.7.7-RXN","compounds":"3-methyl-2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2-methylpropanoyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]","pmd":721.11}
{"X":5066,"KEGG":"R07161","RHEA_ID":12648,"DIRECTION":"BI","MASTER_ID":12645,"metacyc":"1.2.7.8-RXN","compounds":"CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] <=> CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] + S-2-(indol-3-yl)acetyl-CoA","pmd":157.053}
{"X":5067,"KEGG":"R07161","RHEA_ID":12648,"DIRECTION":"BI","MASTER_ID":12645,"metacyc":"1.2.7.8-RXN","compounds":"CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] <=> CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] + S-2-(indol-3-yl)acetyl-CoA","pmd":721.11}
{"X":5068,"KEGG":"R07162","RHEA_ID":33766,"DIRECTION":"BI","MASTER_ID":33763,"compounds":"a (2E)-enoyl-CoA + H(+) + NADPH <=> a 2,3-saturated acyl-CoA + NADP(+)"}
{"X":5069,"KEGG":"R07163","RHEA_ID":19196,"DIRECTION":"BI","MASTER_ID":19193,"compounds":"A + all-trans-13,14-dihydroretinol <=> AH2 + all-trans-retinol","pmd":2.016}
{"X":5070,"KEGG":"R07164","RHEA_ID":11791,"DIRECTION":"BI","MASTER_ID":11788,"metacyc":"1.4.1.21-RXN","compounds":"H2O + L-aspartate + NAD(+) <=> H(+) + NADH + NH4(+) + oxaloacetate","pmd":1.032}
{"X":5071,"KEGG":"R07164","RHEA_ID":11791,"DIRECTION":"BI","MASTER_ID":11788,"metacyc":"1.4.1.21-RXN","compounds":"H2O + L-aspartate + NAD(+) <=> H(+) + NADH + NH4(+) + oxaloacetate","pmd":532.111}
{"X":5072,"KEGG":"R07165","RHEA_ID":11787,"DIRECTION":"BI","MASTER_ID":11784,"metacyc":"1.4.1.21-RXN","compounds":"H2O + L-aspartate + NADP(+) <=> H(+) + NADPH + NH4(+) + oxaloacetate","pmd":1.032}
{"X":5073,"KEGG":"R07165","RHEA_ID":11787,"DIRECTION":"BI","MASTER_ID":11784,"metacyc":"1.4.1.21-RXN","compounds":"H2O + L-aspartate + NADP(+) <=> H(+) + NADPH + NH4(+) + oxaloacetate","pmd":612.077}
{"X":5074,"KEGG":"R07166","RHEA_ID":18128,"DIRECTION":"BI","MASTER_ID":18125,"ecocyc":"RXN-11193","metacyc":"RXN-11193","compounds":"A + a D-alpha-amino acid + H2O <=> a 2-oxocarboxylate + AH2 + NH4(+)"}
{"X":5075,"KEGG":"R07166","RHEA_ID":18128,"DIRECTION":"BI","MASTER_ID":18125,"ecocyc":"RXN-11193","metacyc":"DAADEHYDROG-RXN","compounds":"A + a D-alpha-amino acid + H2O <=> a 2-oxocarboxylate + AH2 + NH4(+)"}
{"X":5076,"KEGG":"R07167","RHEA_ID":18712,"DIRECTION":"BI","MASTER_ID":18709,"compounds":"A + H2O + taurine <=> AH2 + NH4(+) + sulfoacetaldehyde","pmd":1.032}
{"X":5077,"KEGG":"R07168","RHEA_ID":19824,"DIRECTION":"BI","MASTER_ID":19821,"compounds":"(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH","pmd":206.946}
{"X":5078,"KEGG":"R07168","RHEA_ID":19824,"DIRECTION":"BI","MASTER_ID":19821,"compounds":"(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH","pmd":2.016}
{"X":5079,"KEGG":"R07169","RHEA_ID":21271,"DIRECTION":"BI","MASTER_ID":21268,"compounds":"(R)-canadine + 2 NADP(+) <=> berberine + H(+) + 2 NADPH","pmd":3.024}
{"X":5080,"KEGG":"R07169","RHEA_ID":21271,"DIRECTION":"BI","MASTER_ID":21268,"compounds":"(R)-canadine + 2 NADP(+) <=> berberine + H(+) + 2 NADPH","pmd":407.96}
{"X":5081,"KEGG":"R07170","RHEA_ID":10015,"DIRECTION":"BI","MASTER_ID":10012,"compounds":"(R)-6-hydroxynicotine + H2O + O2 <=> 6-hydroxypseudooxynicotine + H2O2","pmd":15.995}
{"X":5082,"KEGG":"R07171","RHEA_ID":11267,"DIRECTION":"BI","MASTER_ID":11264,"compounds":"H(+) + NADH + O2 <=> H2O2 + NAD(+)"}
{"X":5083,"KEGG":"R07172","RHEA_ID":11263,"DIRECTION":"BI","MASTER_ID":11260,"compounds":"H(+) + NADPH + O2 <=> H2O2 + NADP(+)"}
{"X":5084,"KEGG":"R07174","RHEA_ID":23235,"DIRECTION":"BI","MASTER_ID":23232,"compounds":"4 [Fe(III)cytochrome c] + hydrazine <=> 4 [Fe(II)cytochrome c] + 4 H(+) + N2"}
{"X":5085,"KEGG":"R07176","RHEA_ID":21979,"DIRECTION":"BI","MASTER_ID":21976,"compounds":"[thioredoxin]-disulfide + AMP + 2 H(+) + sulfite <=> [thioredoxin]-dithiol + adenosine 5'-phosphosulfate","pmd":79.957}
{"X":5086,"KEGG":"R07177","RHEA_ID":10939,"DIRECTION":"BI","MASTER_ID":10936,"compounds":"6-decylubiquinone + 2 thiosulfate <=> 6-decylubiquinol + tetrathionate","pmd":2.016}
{"X":5087,"KEGG":"R07178","RHEA_ID":15356,"DIRECTION":"BI","MASTER_ID":15353,"compounds":"all-trans-violaxanthin + L-ascorbate <=> all-trans-antheraxanthin + H2O + L-dehydroascorbate","pmd":15.995}
{"X":5088,"KEGG":"R07178","RHEA_ID":15356,"DIRECTION":"BI","MASTER_ID":15353,"compounds":"all-trans-violaxanthin + L-ascorbate <=> all-trans-antheraxanthin + H2O + L-dehydroascorbate","pmd":2.016}
{"X":5089,"KEGG":"R07179","RHEA_ID":21803,"DIRECTION":"BI","MASTER_ID":21800,"compounds":"all-trans-antheraxanthin + L-ascorbate <=> all-trans-zeaxanthin + H2O + L-dehydroascorbate","pmd":15.995}
{"X":5090,"KEGG":"R07179","RHEA_ID":21803,"DIRECTION":"BI","MASTER_ID":21800,"compounds":"all-trans-antheraxanthin + L-ascorbate <=> all-trans-zeaxanthin + H2O + L-dehydroascorbate","pmd":2.016}
{"X":5091,"KEGG":"R07180","RHEA_ID":10011,"DIRECTION":"BI","MASTER_ID":10008,"compounds":"[protein]-dithiol + a hydroperoxide <=> [protein]-disulfide + an alcohol + H2O"}
{"X":5092,"KEGG":"R07181","RHEA_ID":18640,"DIRECTION":"BI","MASTER_ID":18637,"metacyc":"RXN-13947","compounds":"H2 + NADP(+) <=> H(+) + NADPH"}
{"X":5093,"KEGG":"R07181","RHEA_ID":18640,"DIRECTION":"BI","MASTER_ID":18637,"metacyc":"1.12.1.3-RXN","compounds":"H2 + NADP(+) <=> H(+) + NADPH"}
{"X":5094,"KEGG":"R07182","RHEA_ID":12119,"DIRECTION":"BI","MASTER_ID":12116,"metacyc":"RXN0-4141","compounds":"A + H2 <=> AH2"}
{"X":5095,"KEGG":"R07183","RHEA_ID":12880,"DIRECTION":"BI","MASTER_ID":12877,"compounds":"acetylacetone + O2 <=> acetate + H(+) + methylglyoxal"}
{"X":5096,"KEGG":"R07184","RHEA_ID":16036,"DIRECTION":"BI","MASTER_ID":16033,"compounds":"2-oxoglutarate + gibberellin A44 + O2 <=> CO2 + gibberellin A19 + H2O + succinate","pmd":27.995}
{"X":5097,"KEGG":"R07184","RHEA_ID":16036,"DIRECTION":"BI","MASTER_ID":16033,"compounds":"2-oxoglutarate + gibberellin A44 + O2 <=> CO2 + gibberellin A19 + H2O + succinate","pmd":15.995}
{"X":5098,"KEGG":"R07185","RHEA_ID":12203,"DIRECTION":"BI","MASTER_ID":12200,"compounds":"2'-deoxymugineate + 2-oxoglutarate + O2 <=> CO2 + mugineate + succinate","pmd":15.995}
{"X":5099,"KEGG":"R07185","RHEA_ID":12203,"DIRECTION":"BI","MASTER_ID":12200,"compounds":"2'-deoxymugineate + 2-oxoglutarate + O2 <=> CO2 + mugineate + succinate","pmd":27.995}
{"X":5100,"KEGG":"R07186","RHEA_ID":14512,"DIRECTION":"BI","MASTER_ID":14509,"compounds":"2-oxoglutarate + mugineate + O2 <=> 3-epihydroxymugineate + CO2 + H(+) + succinate","pmd":15.995}
{"X":5101,"KEGG":"R07186","RHEA_ID":14512,"DIRECTION":"BI","MASTER_ID":14509,"compounds":"2-oxoglutarate + mugineate + O2 <=> 3-epihydroxymugineate + CO2 + H(+) + succinate","pmd":27.995}
{"X":5102,"KEGG":"R07187","RHEA_ID":20068,"DIRECTION":"BI","MASTER_ID":20065,"compounds":"2'-deoxymugineate + 2-oxoglutarate + O2 <=> 3-epihydroxy-2'-deoxymugineate + CO2 + H(+) + succinate","pmd":27.995}
{"X":5103,"KEGG":"R07187","RHEA_ID":20068,"DIRECTION":"BI","MASTER_ID":20065,"compounds":"2'-deoxymugineate + 2-oxoglutarate + O2 <=> 3-epihydroxy-2'-deoxymugineate + CO2 + H(+) + succinate","pmd":15.995}
{"X":5104,"KEGG":"R07190","RHEA_ID":23047,"DIRECTION":"BI","MASTER_ID":23044,"compounds":"H(+) + N,N-dihydroxy-L-tyrosine <=> (E)-4-hydroxyphenylacetaldehyde oxime + CO2 + H2O","pmd":62}
{"X":5105,"KEGG":"R07191","RHEA_ID":11443,"DIRECTION":"BI","MASTER_ID":11440,"compounds":"2,3,5,6-tetrachlorophenol + NADPH + O2 <=> 2,3,5,6-tetrachlorohydroquinone + H2O + NADP(+)","pmd":15.995}
{"X":5106,"KEGG":"R07191","RHEA_ID":11443,"DIRECTION":"BI","MASTER_ID":11440,"compounds":"2,3,5,6-tetrachlorophenol + NADPH + O2 <=> 2,3,5,6-tetrachlorohydroquinone + H2O + NADP(+)","pmd":499.21}
{"X":5107,"KEGG":"R07194","RHEA_ID":11795,"DIRECTION":"BI","MASTER_ID":11792,"compounds":"H(+) + NADH + O2 + propene <=> 1,2-epoxypropane + H2O + NAD(+)"}
{"X":5108,"KEGG":"R07195","RHEA_ID":26050,"DIRECTION":"BI","MASTER_ID":26047,"compounds":"(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] <=> glyceollin II + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]","pmd":2.016}
{"X":5109,"KEGG":"R07196","RHEA_ID":26054,"DIRECTION":"BI","MASTER_ID":26051,"compounds":"(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] <=> glyceollin III + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]","pmd":2.016}
{"X":5110,"KEGG":"R07197","RHEA_ID":22847,"DIRECTION":"BI","MASTER_ID":22844,"compounds":"(6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] <=> glyceollin I + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]","pmd":2.016}
{"X":5111,"KEGG":"R07198","RHEA_ID":15700,"DIRECTION":"BI","MASTER_ID":15697,"compounds":"liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + licodione + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":5112,"KEGG":"R07199","RHEA_ID":24087,"DIRECTION":"BI","MASTER_ID":24084,"compounds":"all-trans-zeaxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> all-trans-antheraxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":5113,"KEGG":"R07200","RHEA_ID":14940,"DIRECTION":"BI","MASTER_ID":14937,"compounds":"all-trans-antheraxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> all-trans-violaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":5114,"KEGG":"R07201","RHEA_ID":10127,"DIRECTION":"BI","MASTER_ID":10124,"compounds":"H(+) + NADPH + O2 + phenylacetone <=> benzyl acetate + H2O + NADP(+)","pmd":595.023}
{"X":5115,"KEGG":"R07201","RHEA_ID":10127,"DIRECTION":"BI","MASTER_ID":10124,"compounds":"H(+) + NADPH + O2 + phenylacetone <=> benzyl acetate + H2O + NADP(+)","pmd":15.995}
{"X":5116,"KEGG":"R07202","RHEA_ID":12900,"DIRECTION":"BI","MASTER_ID":12897,"compounds":"2-cis-(+)-abscisate + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-8'-hydroxyabscisate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":5117,"KEGG":"R07203","RHEA_ID":18860,"DIRECTION":"BI","MASTER_ID":18857,"compounds":"lithocholate + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxylithocholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":5118,"KEGG":"R07204","RHEA_ID":15264,"DIRECTION":"BI","MASTER_ID":15261,"compounds":"5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase] <=> 5beta-cholestane-3alpha,7alpha,12alpha-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":5119,"KEGG":"R07205","RHEA_ID":17860,"DIRECTION":"BI","MASTER_ID":17857,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + taurochenodeoxycholate <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taurohyocholate","pmd":15.995}
{"X":5120,"KEGG":"R07206","RHEA_ID":23647,"DIRECTION":"BI","MASTER_ID":23644,"compounds":"lithocholate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + hyodeoxycholate + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":5121,"KEGG":"R07207","RHEA_ID":22719,"DIRECTION":"BI","MASTER_ID":22716,"compounds":"cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":5122,"KEGG":"R07208","RHEA_ID":46127,"DIRECTION":"BI","MASTER_ID":46124,"compounds":"(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":5123,"KEGG":"R07209","RHEA_ID":24311,"DIRECTION":"BI","MASTER_ID":24308,"compounds":"25-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 7alpha,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":5124,"KEGG":"R07210","RHEA_ID":23067,"DIRECTION":"BI","MASTER_ID":23064,"compounds":"an alkanesulfonate + FMNH2 + O2 <=> an aldehyde + FMN + 2 H(+) + H2O + sulfite","pmd":2.016}
{"X":5125,"KEGG":"R07211","RHEA_ID":20276,"DIRECTION":"BI","MASTER_ID":20273,"compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 <=> (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine","pmd":15.995}
{"X":5126,"KEGG":"R07212","RHEA_ID":18204,"DIRECTION":"BI","MASTER_ID":18201,"compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2 <=> (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa","pmd":15.995}
{"X":5127,"KEGG":"R07213","RHEA_ID":16712,"DIRECTION":"BI","MASTER_ID":16709,"compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 <=> (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 5-hydroxy-L-tryptophan","pmd":15.995}
{"X":5128,"KEGG":"R07214","RHEA_ID":23643,"DIRECTION":"BI","MASTER_ID":23640,"compounds":"1-aminocyclopropane-1-carboxylate + L-ascorbate + O2 <=> CO2 + ethene + 2 H2O + hydrogen cyanide + L-dehydroascorbate","pmd":72.969}
{"X":5129,"KEGG":"R07214","RHEA_ID":23643,"DIRECTION":"BI","MASTER_ID":23640,"compounds":"1-aminocyclopropane-1-carboxylate + L-ascorbate + O2 <=> CO2 + ethene + 2 H2O + hydrogen cyanide + L-dehydroascorbate","pmd":2.016}
{"X":5130,"KEGG":"R07215","RHEA_ID":46559,"DIRECTION":"BI","MASTER_ID":46556,"metacyc":"1.14.21.6-RXN","compounds":"5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + cholesta-5,7-dien-3beta-ol + 2 H2O","pmd":2.016}
{"X":5131,"KEGG":"R07215","RHEA_ID":18920,"DIRECTION":"BI","MASTER_ID":18917,"compounds":"5alpha-cholest-7-en-3beta-ol + H(+) + NADPH + O2 <=> cholesta-5,7-dien-3beta-ol + 2 H2O + NADP(+)","pmd":2.016}
{"X":5132,"KEGG":"R07216","RHEA_ID":20172,"DIRECTION":"BI","MASTER_ID":20169,"compounds":"H(+) + NADPH + O2 + tetradecanoyl-CoA <=> (11E)-tetradecenoyl-CoA + 2 H2O + NADP(+)","pmd":2.016}
{"X":5133,"KEGG":"R07216","RHEA_ID":20172,"DIRECTION":"BI","MASTER_ID":20169,"compounds":"H(+) + NADPH + O2 + tetradecanoyl-CoA <=> (11E)-tetradecenoyl-CoA + 2 H2O + NADP(+)","pmd":230.207}
{"X":5134,"KEGG":"R07217","RHEA_ID":14956,"DIRECTION":"BI","MASTER_ID":14953,"compounds":"H(+) + NADPH + O2 + tetradecanoyl-CoA <=> (11Z)-tetradecenoyl-CoA + 2 H2O + NADP(+)","pmd":230.207}
{"X":5135,"KEGG":"R07217","RHEA_ID":14956,"DIRECTION":"BI","MASTER_ID":14953,"compounds":"H(+) + NADPH + O2 + tetradecanoyl-CoA <=> (11Z)-tetradecenoyl-CoA + 2 H2O + NADP(+)","pmd":2.016}
{"X":5136,"KEGG":"R07218","RHEA_ID":21107,"DIRECTION":"BI","MASTER_ID":21104,"compounds":"AH2 + cholesterol + O2 <=> 25-hydroxycholesterol + A + H2O","pmd":15.995}
{"X":5137,"KEGG":"R07220","RHEA_ID":16720,"DIRECTION":"BI","MASTER_ID":16717,"metacyc":"RXN-8658","compounds":"deoxycholate + FAD + H(+) + H2O <=> cholate + FADH2","pmd":15.995}
{"X":5138,"KEGG":"R07220","RHEA_ID":16720,"DIRECTION":"BI","MASTER_ID":16717,"metacyc":"RXN-8658","compounds":"deoxycholate + FAD + H(+) + H2O <=> cholate + FADH2","pmd":2.016}
{"X":5139,"KEGG":"R07221","RHEA_ID":22811,"DIRECTION":"BI","MASTER_ID":22808,"compounds":"6-hydroxynicotinate + H2O + O2 <=> 2,6-dihydroxynicotinate + H2O2","pmd":15.995}
{"X":5140,"KEGG":"R07222","RHEA_ID":15708,"DIRECTION":"BI","MASTER_ID":15705,"compounds":"2 a ubiquinone + H2O + phenylacetyl-CoA <=> 2 a ubiquinol + phenylglyoxylyl-CoA","pmd":13.979}
{"X":5141,"KEGG":"R07223","RHEA_ID":15144,"DIRECTION":"BI","MASTER_ID":15141,"compounds":"4-methylphenol + H2O + 4 oxidized [azurin] <=> 4-hydroxybenzaldehyde + 4 H(+) + 4 reduced [azurin]"}
{"X":5142,"KEGG":"R07224","RHEA_ID":12267,"DIRECTION":"BI","MASTER_ID":12264,"compounds":"2',4,4',6'-tetrahydroxychalcone + H(+) + O2 <=> aureusidin + H2O","pmd":13.979}
{"X":5143,"KEGG":"R07225","RHEA_ID":11363,"DIRECTION":"BI","MASTER_ID":11360,"compounds":"2 2',3,4,4',6'-pentahydroxychalcone + 2 H(+) + O2 <=> 2 aureusidin + 2 H2O","pmd":2.016}
{"X":5144,"KEGG":"R07226","RHEA_ID":12235,"DIRECTION":"BI","MASTER_ID":12232,"compounds":"[thioredoxin]-disulfide + acetyl phosphate + H2O + NH4(+) <=> [thioredoxin]-dithiol + glycine + H(+) + phosphate"}
{"X":5145,"KEGG":"R07227","RHEA_ID":12828,"DIRECTION":"BI","MASTER_ID":12825,"metacyc":"1.21.4.3-RXN","compounds":"[thioredoxin]-disulfide + acetyl phosphate + H2O + methylamine <=> [thioredoxin]-dithiol + H(+) + phosphate + sarcosine"}
{"X":5146,"KEGG":"R07228","RHEA_ID":11851,"DIRECTION":"BI","MASTER_ID":11848,"metacyc":"1.21.4.4-RXN","compounds":"[thioredoxin]-disulfide + acetyl phosphate + H2O + trimethylamine <=> [thioredoxin]-dithiol + betaine + H(+) + phosphate","pmd":22.909}
{"X":5147,"KEGG":"R07229","RHEA_ID":14032,"DIRECTION":"BI","MASTER_ID":14029,"compounds":"A + H2O + selenite <=> AH2 + selenate"}
{"X":5148,"KEGG":"R07230","RHEA_ID":18900,"DIRECTION":"BI","MASTER_ID":18897,"compounds":"3,3',5'-triiodo-L-thyronine + A + H(+) + iodide <=> AH2 + L-thyroxine","pmd":125.897}
{"X":5149,"KEGG":"R07232","RHEA_ID":16500,"DIRECTION":"BI","MASTER_ID":16497,"compounds":"adenosine(1618) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine(1618) in 23S rRNA + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5150,"KEGG":"R07233","RHEA_ID":42903,"DIRECTION":"BI","MASTER_ID":42900,"compounds":"guanosine(745) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylguanosine(745) in 23S rRNA + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5151,"KEGG":"R07233","RHEA_ID":42907,"DIRECTION":"BI","MASTER_ID":42904,"compounds":"guanosine(748) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylguanosine(748) in 23S rRNA + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5152,"KEGG":"R07234","RHEA_ID":42739,"DIRECTION":"BI","MASTER_ID":42736,"compounds":"guanosine(1207) in 16S rRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5153,"KEGG":"R07234","RHEA_ID":42747,"DIRECTION":"BI","MASTER_ID":42744,"compounds":"guanosine(1835) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5154,"KEGG":"R07234","RHEA_ID":42743,"DIRECTION":"BI","MASTER_ID":42740,"compounds":"guanosine(2445) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5155,"KEGG":"R07234","RHEA_ID":23551,"DIRECTION":"BI","MASTER_ID":23548,"compounds":"guanosine(966) in 16S rRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5156,"KEGG":"R07235","RHEA_ID":17052,"DIRECTION":"BI","MASTER_ID":17049,"compounds":"3-demethylubiquinol-9 + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + ubiquinol-9","pmd":14.016}
{"X":5157,"KEGG":"R07236","RHEA_ID":24015,"DIRECTION":"BI","MASTER_ID":24012,"compounds":"gamma-tocopherol + S-adenosyl-L-methionine <=> (+)-alpha-tocopherol + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5158,"KEGG":"R07237","RHEA_ID":19092,"DIRECTION":"BI","MASTER_ID":19089,"compounds":"S-adenosyl-L-methionine + uroporphyrinogen III <=> H(+) + precorrin-1 + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5159,"KEGG":"R07238","RHEA_ID":21975,"DIRECTION":"BI","MASTER_ID":21972,"compounds":"precorrin-1 + S-adenosyl-L-methionine <=> precorrin-2 + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5160,"KEGG":"R07239","RHEA_ID":21875,"DIRECTION":"BI","MASTER_ID":21872,"compounds":"L-arginyl-[cytochrome c] + S-adenosyl-L-methionine <=> H(+) + N(omega)-methyl-L-arginyl-[cytochrome c] + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5161,"KEGG":"R07240","RHEA_ID":17084,"DIRECTION":"BI","MASTER_ID":17081,"compounds":"S-adenosyl-L-methionine + trans-isoeugenol <=> H(+) + S-adenosyl-L-homocysteine + trans-isomethyleugenol","pmd":14.016}
{"X":5162,"KEGG":"R07241","RHEA_ID":14776,"DIRECTION":"BI","MASTER_ID":14773,"compounds":"2 NADPH + palmatine + S-adenosyl-L-methionine <=> corydaline + 2 NADP(+) + S-adenosyl-L-homocysteine","pmd":17.039}
{"X":5163,"KEGG":"R07241","RHEA_ID":14776,"DIRECTION":"BI","MASTER_ID":14773,"compounds":"2 NADPH + palmatine + S-adenosyl-L-methionine <=> corydaline + 2 NADP(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5164,"KEGG":"R07241","RHEA_ID":14776,"DIRECTION":"BI","MASTER_ID":14773,"compounds":"2 NADPH + palmatine + S-adenosyl-L-methionine <=> corydaline + 2 NADP(+) + S-adenosyl-L-homocysteine","pmd":360.969}
{"X":5165,"KEGG":"R07242","RHEA_ID":21611,"DIRECTION":"BI","MASTER_ID":21608,"compounds":"isoliquiritigenin + S-adenosyl-L-methionine <=> 2'-O-methylisoliquiritigenin + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5166,"KEGG":"R07243","RHEA_ID":15456,"DIRECTION":"BI","MASTER_ID":15453,"compounds":"S-adenosyl-L-methionine + sarcosine <=> H(+) + N,N-dimethylglycine + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5167,"KEGG":"R07244","RHEA_ID":10075,"DIRECTION":"BI","MASTER_ID":10072,"compounds":"N,N-dimethylglycine + S-adenosyl-L-methionine <=> betaine + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5168,"KEGG":"R07245","RHEA_ID":18612,"DIRECTION":"BI","MASTER_ID":18609,"metacyc":"2.1.3.9-RXN","compounds":"carbamoyl phosphate + N(2)-acetyl-L-ornithine <=> H(+) + N(2)-acetyl-L-citrulline + phosphate","pmd":43.006}
{"X":5169,"KEGG":"R07245","RHEA_ID":18612,"DIRECTION":"BI","MASTER_ID":18609,"metacyc":"2.1.3.9-RXN","compounds":"carbamoyl phosphate + N(2)-acetyl-L-ornithine <=> H(+) + N(2)-acetyl-L-citrulline + phosphate","pmd":76.124}
{"X":5170,"KEGG":"R07247","RHEA_ID":11751,"DIRECTION":"BI","MASTER_ID":11748,"compounds":"fluoroacetaldehyde + L-threonine <=> 4-fluoro-L-threonine + acetaldehyde","pmd":17.991}
{"X":5171,"KEGG":"R07248","RHEA_ID":23475,"DIRECTION":"BI","MASTER_ID":23472,"compounds":"2 alpha,alpha'-trehalose 6-mycolate <=> alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose","pmd":476.459}
{"X":5172,"KEGG":"R07249","RHEA_ID":11611,"DIRECTION":"BI","MASTER_ID":11608,"metacyc":"RXN-15208","compounds":"[(2->8)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA <=> [(2->8)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA","pmd":42.011}
{"X":5173,"KEGG":"R07250","RHEA_ID":22227,"DIRECTION":"BI","MASTER_ID":22224,"compounds":"3 H(+) + 3 malonyl-CoA + N-methylanthraniloyl-CoA <=> 1,3-dihydroxy-N-methylacridone + 3 CO2 + 4 CoA + H2O","pmd":86}
{"X":5174,"KEGG":"R07250","RHEA_ID":22227,"DIRECTION":"BI","MASTER_ID":22224,"compounds":"3 H(+) + 3 malonyl-CoA + N-methylanthraniloyl-CoA <=> 1,3-dihydroxy-N-methylacridone + 3 CO2 + 4 CoA + H2O","pmd":133.053}
{"X":5175,"KEGG":"R07251","RHEA_ID":18568,"DIRECTION":"BI","MASTER_ID":18565,"compounds":"19 H(+) + holo-[lovastatin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine <=> 9 CO2 + 9 CoA + dihydromonacolin L-[lovastatin nonaketide synthase] + 6 H2O + 11 NADP(+) + S-adenosyl-L-homocysteine","pmd":86}
{"X":5176,"KEGG":"R07251","RHEA_ID":18568,"DIRECTION":"BI","MASTER_ID":18565,"compounds":"19 H(+) + holo-[lovastatin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine <=> 9 CO2 + 9 CoA + dihydromonacolin L-[lovastatin nonaketide synthase] + 6 H2O + 11 NADP(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5177,"KEGG":"R07251","RHEA_ID":18568,"DIRECTION":"BI","MASTER_ID":18565,"compounds":"19 H(+) + holo-[lovastatin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine <=> 9 CO2 + 9 CoA + dihydromonacolin L-[lovastatin nonaketide synthase] + 6 H2O + 11 NADP(+) + S-adenosyl-L-homocysteine","pmd":22.024}
{"X":5178,"KEGG":"R07252","RHEA_ID":18840,"DIRECTION":"BI","MASTER_ID":18837,"compounds":"10-deacetyltaxuyunnanin C + acetyl-CoA <=> CoA + taxuyunnanin C","pmd":42.011}
{"X":5179,"KEGG":"R07252","RHEA_ID":18840,"DIRECTION":"BI","MASTER_ID":18837,"compounds":"10-deacetyltaxuyunnanin C + acetyl-CoA <=> CoA + taxuyunnanin C","pmd":42.01}
{"X":5180,"KEGG":"R07253","RHEA_ID":12243,"DIRECTION":"BI","MASTER_ID":12240,"compounds":"acetyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH <=> 6-methylsalicylate + 3 CO2 + 4 CoA + H2O + NADP(+)","pmd":86}
{"X":5181,"KEGG":"R07253","RHEA_ID":12243,"DIRECTION":"BI","MASTER_ID":12240,"compounds":"acetyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH <=> 6-methylsalicylate + 3 CO2 + 4 CoA + H2O + NADP(+)","pmd":22.024}
{"X":5182,"KEGG":"R07253","RHEA_ID":12243,"DIRECTION":"BI","MASTER_ID":12240,"compounds":"acetyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH <=> 6-methylsalicylate + 3 CO2 + 4 CoA + H2O + NADP(+)","pmd":42.011}
{"X":5183,"KEGG":"R07255","RHEA_ID":16028,"DIRECTION":"BI","MASTER_ID":16025,"metacyc":"2.3.1.171-RXN","compounds":"an anthocyanidin 3-O-beta-D-glucoside + malonyl-CoA <=> an anthocyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + CoA","pmd":86}
{"X":5184,"KEGG":"R07256","RHEA_ID":16244,"DIRECTION":"BI","MASTER_ID":16241,"compounds":"an NDP-alpha-D-glucose + D-fructose <=> a ribonucleoside 5'-diphosphate + H(+) + sucrose","pmd":162.053}
{"X":5185,"KEGG":"R07257","RHEA_ID":28121,"DIRECTION":"BI","MASTER_ID":28118,"metacyc":"2.4.1.54-RXN","compounds":"di-trans,octa-cis-undecaprenyl phosphate + GDP-alpha-D-mannose <=> D-mannosyl di-trans,octa-cis-undecaprenyl phosphate + GDP","pmd":162.053}
{"X":5186,"KEGG":"R07257","RHEA_ID":28121,"DIRECTION":"BI","MASTER_ID":28118,"metacyc":"2.4.1.54-RXN","compounds":"di-trans,octa-cis-undecaprenyl phosphate + GDP-alpha-D-mannose <=> D-mannosyl di-trans,octa-cis-undecaprenyl phosphate + GDP","pmd":403.641}
{"X":5187,"KEGG":"R07260","RHEA_ID":20684,"DIRECTION":"BI","MASTER_ID":20681,"compounds":"cis-zeatin + UDP-alpha-D-glucose <=> H(+) + O-beta-D-glucosyl-cis-zeatin + UDP","pmd":162.053}
{"X":5188,"KEGG":"R07261","RHEA_ID":15876,"DIRECTION":"BI","MASTER_ID":15873,"metacyc":"2.4.1.242-RXN","compounds":"[(1->4)-alpha-D-glucosyl](n) + an NDP-alpha-D-glucose <=> [(1->4)-alpha-D-glucosyl](n+1) + a ribonucleoside 5'-diphosphate + H(+)"}
{"X":5189,"KEGG":"R07262","RHEA_ID":26312,"DIRECTION":"BI","MASTER_ID":26309,"compounds":"1,4-dihydroxy-2-naphthoyl-CoA + H2O <=> 1,4-dihydroxy-2-naphthoate + CoA + H(+)","pmd":186.032}
{"X":5190,"KEGG":"R07263","RHEA_ID":26565,"DIRECTION":"BI","MASTER_ID":26562,"compounds":"2-succinylbenzoyl-CoA + H(+) <=> 1,4-dihydroxy-2-naphthoyl-CoA + H2O","pmd":18.011}
{"X":5191,"KEGG":"R07264","RHEA_ID":11179,"DIRECTION":"BI","MASTER_ID":11176,"metacyc":"2.4.1.230-RXN","compounds":"2-alpha-D-glucosyl-D-glucose + phosphate <=> beta-D-glucose 1-phosphate + D-glucose","pmd":82.087}
{"X":5192,"KEGG":"R07265","RHEA_ID":16260,"DIRECTION":"BI","MASTER_ID":16257,"metacyc":"RXN-4441","compounds":"alpha,alpha-trehalose + phosphate <=> alpha-D-glucose + alpha-D-glucose 1-phosphate","pmd":82.087}
{"X":5193,"KEGG":"R07266","RHEA_ID":15408,"DIRECTION":"BI","MASTER_ID":15405,"compounds":"(3R)-hydroxybutanoyl-CoA + [(3R)-hydroxybutanoate](n) <=> [(3R)-hydroxybutanoate](n+1) + CoA","pmd":178.048}
{"X":5194,"KEGG":"R07266","RHEA_ID":15408,"DIRECTION":"BI","MASTER_ID":15405,"compounds":"(3R)-hydroxybutanoyl-CoA + [(3R)-hydroxybutanoate](n) <=> [(3R)-hydroxybutanoate](n+1) + CoA","pmd":162.053}
{"X":5195,"KEGG":"R07266","RHEA_ID":35630,"DIRECTION":"BI","MASTER_ID":35627,"compounds":"delphinidin 3,5-bis-O-beta-D-glucoside + UDP-alpha-D-glucose <=> delphinidin 3,3',5-tri-O-beta-D-glucoside + H(+) + UDP","pmd":178.048}
{"X":5196,"KEGG":"R07266","RHEA_ID":35630,"DIRECTION":"BI","MASTER_ID":35627,"compounds":"delphinidin 3,5-bis-O-beta-D-glucoside + UDP-alpha-D-glucose <=> delphinidin 3,3',5-tri-O-beta-D-glucoside + H(+) + UDP","pmd":162.053}
{"X":5197,"KEGG":"R07267","RHEA_ID":11327,"DIRECTION":"BI","MASTER_ID":11324,"compounds":"all-trans-octaprenyl diphosphate + isopentenyl diphosphate <=> all-trans-nonaprenyl diphosphate + diphosphate","pmd":544.501}
{"X":5198,"KEGG":"R07267","RHEA_ID":11327,"DIRECTION":"BI","MASTER_ID":11324,"compounds":"all-trans-octaprenyl diphosphate + isopentenyl diphosphate <=> all-trans-nonaprenyl diphosphate + diphosphate","pmd":68.063}
{"X":5199,"KEGG":"R07268","RHEA_ID":14728,"DIRECTION":"BI","MASTER_ID":14725,"compounds":"2 ATP + 2 cob(II)inamide + reduced [electron-transfer flavoprotein] <=> 2 adenosylcob(III)inamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate"}
{"X":5200,"KEGG":"R07270","RHEA_ID":10919,"DIRECTION":"BI","MASTER_ID":10916,"compounds":"(1R,2R,3R)-prephytoene diphosphate <=> all-trans-phytoene + diphosphate","pmd":177.943}
{"X":5201,"KEGG":"R07271","RHEA_ID":19348,"DIRECTION":"BI","MASTER_ID":19345,"compounds":"(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate <=> (6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate","pmd":68.063}
{"X":5202,"KEGG":"R07271","RHEA_ID":19348,"DIRECTION":"BI","MASTER_ID":19345,"compounds":"(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate <=> (6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate","pmd":94.125}
{"X":5203,"KEGG":"R07272","RHEA_ID":23187,"DIRECTION":"BI","MASTER_ID":23184,"compounds":"(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate <=> (6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate","pmd":94.125}
{"X":5204,"KEGG":"R07272","RHEA_ID":23187,"DIRECTION":"BI","MASTER_ID":23184,"compounds":"(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate <=> (6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate","pmd":68.063}
{"X":5205,"KEGG":"R07273","RHEA_ID":17712,"DIRECTION":"BI","MASTER_ID":17709,"compounds":"4-hydroxybenzoate + all-trans-nonaprenyl diphosphate <=> 4-hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate","pmd":612.563}
{"X":5206,"KEGG":"R07273","RHEA_ID":17712,"DIRECTION":"BI","MASTER_ID":17709,"compounds":"4-hydroxybenzoate + all-trans-nonaprenyl diphosphate <=> 4-hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate","pmd":39.912}
{"X":5207,"KEGG":"R07274","RHEA_ID":10255,"DIRECTION":"BI","MASTER_ID":10252,"metacyc":"2.5.1.65-RXN","compounds":"H(+) + hydrogen sulfide + O-phospho-L-serine <=> L-cysteine + phosphate","pmd":63.989}
{"X":5208,"KEGG":"R07275","RHEA_ID":18220,"DIRECTION":"BI","MASTER_ID":18217,"ecocyc":"DIAMTRANSAM-RXN","metacyc":"DIAMTRANSAM-RXN","compounds":"2-oxoglutarate + an alkane-alpha,omega-diamine <=> an omega-aminoaldehyde + L-glutamate","pmd":1.032}
{"X":5209,"KEGG":"R07276","RHEA_ID":22883,"DIRECTION":"BI","MASTER_ID":22880,"compounds":"2-oxoglutarate + L-arogenate <=> L-glutamate + prephenate","pmd":1.032}
{"X":5210,"KEGG":"R07277","RHEA_ID":22107,"DIRECTION":"BI","MASTER_ID":22104,"metacyc":"2.6.1.80-RXN","compounds":"2-oxoglutarate + nicotianamine <=> 3''-deamino-3''-oxonicotianamine + L-glutamate","pmd":1.032}
{"X":5211,"KEGG":"R07279","RHEA_ID":21807,"DIRECTION":"BI","MASTER_ID":21804,"compounds":"ATP + myo-inositol <=> 1D-myo-inositol 3-phosphate + ADP + H(+)","pmd":79.966}
{"X":5212,"KEGG":"R07280","RHEA_ID":25200,"DIRECTION":"BI","MASTER_ID":25197,"compounds":"5-amino-6-(5-phospho-D-ribitylamino)uracil + H2O <=> 5-amino-6-(D-ribitylamino)uracil + phosphate","pmd":79.966}
{"X":5213,"KEGG":"R07281","RHEA_ID":18460,"DIRECTION":"BI","MASTER_ID":18457,"compounds":"D-ribulose 5-phosphate <=> (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)","pmd":46.006}
{"X":5214,"KEGG":"R07282","RHEA_ID":22099,"DIRECTION":"BI","MASTER_ID":22096,"ecocyc":"2.7.7.8-RXN","metacyc":"2.7.7.8-RXN","compounds":"phosphate + RNA(n+1) <=> a ribonucleoside 5'-diphosphate + RNA(n)"}
{"X":5215,"KEGG":"R07285","RHEA_ID":10631,"DIRECTION":"BI","MASTER_ID":10628,"ecocyc":"TRNA-NUCLEOTIDYLTRANSFERASE-RXN","metacyc":"TRNA-NUCLEOTIDYLTRANSFERASE-RXN","compounds":"phosphate + tRNA(n+1) <=> a ribonucleoside 5'-diphosphate + tRNA(n)"}
{"X":5216,"KEGG":"R07287","RHEA_ID":10911,"DIRECTION":"BI","MASTER_ID":10908,"metacyc":"RXN-8729","compounds":"3'-phosphoadenylyl sulfate + glycolithocholate <=> adenosine 3',5'-bisphosphate + H(+) + sulfoglycolithocholate","pmd":6.29}
{"X":5217,"KEGG":"R07287","RHEA_ID":10911,"DIRECTION":"BI","MASTER_ID":10908,"metacyc":"RXN-8729","compounds":"3'-phosphoadenylyl sulfate + glycolithocholate <=> adenosine 3',5'-bisphosphate + H(+) + sulfoglycolithocholate","pmd":5.282}
{"X":5218,"KEGG":"R07289","RHEA_ID":17692,"DIRECTION":"BI","MASTER_ID":17689,"compounds":"3'-phosphoadenylyl sulfate + glycochenodeoxycholate <=> adenosine 3',5'-bisphosphate + glycochenodeoxycholate 7-sulfate + H(+)","pmd":22.285}
{"X":5219,"KEGG":"R07290","RHEA_ID":16548,"DIRECTION":"BI","MASTER_ID":16545,"ecocyc":"RXN0-1382","compounds":"formyl-CoA + oxalate <=> formate + oxalyl-CoA","pmd":43.99}
{"X":5220,"KEGG":"R07293","RHEA_ID":15248,"DIRECTION":"BI","MASTER_ID":15245,"compounds":"a monoacylglycerol + H2O <=> a fatty acid + glycerol + H(+)"}
{"X":5221,"KEGG":"R07294","RHEA_ID":15340,"DIRECTION":"BI","MASTER_ID":15337,"compounds":"H2O + phenylglyoxylyl-CoA <=> CoA + H(+) + phenylglyoxylate","pmd":132.021}
{"X":5222,"KEGG":"R07295","RHEA_ID":49439,"DIRECTION":"BI","MASTER_ID":49436,"compounds":"cholate + deoxycholoyl-CoA <=> choloyl-CoA + deoxycholate","pmd":15.995}
{"X":5223,"KEGG":"R07295","RHEA_ID":17696,"DIRECTION":"BI","MASTER_ID":17693,"compounds":"deoxycholoyl-CoA + H2O <=> CoA + deoxycholate + H(+)","pmd":15.995}
{"X":5224,"KEGG":"R07296","RHEA_ID":14544,"DIRECTION":"BI","MASTER_ID":14541,"metacyc":"3.1.2.27-RXN","compounds":"choloyl-CoA + H2O <=> cholate + CoA + H(+)"}
{"X":5225,"KEGG":"R07297","RHEA_ID":12487,"DIRECTION":"BI","MASTER_ID":12484,"metacyc":"NUCLEOTIDASE-RXN","compounds":"a ribonucleoside 5'-phosphate + H2O <=> a ribonucleoside + phosphate"}
{"X":5226,"KEGG":"R07298","RHEA_ID":46087,"DIRECTION":"BI","MASTER_ID":46084,"compounds":"H2O + sn-glycerol 1-phosphate <=> glycerol + phosphate"}
{"X":5227,"KEGG":"R07299","RHEA_ID":17196,"DIRECTION":"BI","MASTER_ID":17193,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate"}
{"X":5228,"KEGG":"R07300","RHEA_ID":23931,"DIRECTION":"BI","MASTER_ID":23928,"metacyc":"ACETYLSPERMIDINE-DEACETYLASE-RXN","compounds":"H2O + N(8)-acetylspermidine <=> acetate + spermidine","pmd":42.011}
{"X":5229,"KEGG":"R07301","RHEA_ID":23955,"DIRECTION":"BI","MASTER_ID":23952,"compounds":"H2O + N-(2-phenylethyl)acetamide <=> 2-phenylethylamine + acetate","pmd":42.011}
{"X":5230,"KEGG":"R07302","RHEA_ID":12575,"DIRECTION":"BI","MASTER_ID":12572,"compounds":"(R)-1-aminopropan-2-ol + adenosylcob(III)yrate + ATP <=> adenosylcob(III)inamide + ADP + H(+) + phosphate","pmd":79.966}
{"X":5231,"KEGG":"R07303","RHEA_ID":12099,"DIRECTION":"BI","MASTER_ID":12096,"metacyc":"3.5.1.91-RXN","compounds":"H2O + N-benzylformamide <=> benzylamine + formate","pmd":27.995}
{"X":5232,"KEGG":"R07305","RHEA_ID":14644,"DIRECTION":"BI","MASTER_ID":14641,"compounds":"cyanurate + H2O <=> biuret + CO2"}
{"X":5233,"KEGG":"R07306","RHEA_ID":22471,"DIRECTION":"BI","MASTER_ID":22468,"compounds":"GTP + 3 H2O <=> 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 H(+) + 2 phosphate","pmd":141.922}
{"X":5234,"KEGG":"R07307","RHEA_ID":19208,"DIRECTION":"BI","MASTER_ID":19205,"compounds":"dCTP + 2 H2O <=> diphosphate + dUMP + NH4(+)","pmd":158.949}
{"X":5235,"KEGG":"R07308","RHEA_ID":22191,"DIRECTION":"BI","MASTER_ID":22188,"compounds":"an (R)-2-haloacid + H2O <=> a (2S)-2-hydroxycarboxylate + a halide anion + H(+)"}
{"X":5236,"KEGG":"R07309","RHEA_ID":12075,"DIRECTION":"BI","MASTER_ID":12072,"compounds":"an (S)-2-haloacid + H2O <=> a (2S)-2-hydroxycarboxylate + a halide anion + H(+)"}
{"X":5237,"KEGG":"R07310","RHEA_ID":16196,"DIRECTION":"BI","MASTER_ID":16193,"compounds":"an (R)-2-haloacid + H2O <=> a (2R)-2-hydroxycarboxylate + a halide anion + H(+)"}
{"X":5238,"KEGG":"R07311","RHEA_ID":12948,"DIRECTION":"BI","MASTER_ID":12945,"metacyc":"RXN-624","compounds":"2'-hydroxybiphenyl-2-sulfinate + H2O <=> 2-hydroxybiphenyl + H(+) + sulfite","pmd":63.962}
{"X":5239,"KEGG":"R07312","RHEA_ID":22735,"DIRECTION":"BI","MASTER_ID":22732,"compounds":"4-hydroxyphenylacetate + H(+) <=> 4-methylphenol + CO2","pmd":43.99}
{"X":5240,"KEGG":"R07313","RHEA_ID":18444,"DIRECTION":"BI","MASTER_ID":18441,"metacyc":"4.1.1.84-RXN","compounds":"D-dopachrome + H(+) <=> 5,6-dihydroxyindole + CO2","pmd":43.99}
{"X":5241,"KEGG":"R07314","RHEA_ID":20727,"DIRECTION":"BI","MASTER_ID":20724,"compounds":"a 4-saturated-(3S)-hydroxyacyl-CoA <=> a (3E)-enoyl-CoA + H2O"}
{"X":5242,"KEGG":"R07315","RHEA_ID":11123,"DIRECTION":"BI","MASTER_ID":11120,"compounds":"cyanate + 3 H(+) + hydrogencarbonate <=> 2 CO2 + NH4(+)"}
{"X":5243,"KEGG":"R07316","RHEA_ID":15652,"DIRECTION":"BI","MASTER_ID":15649,"compounds":"carbamate + 2 H(+) <=> CO2 + NH4(+)"}
{"X":5244,"KEGG":"R07317","RHEA_ID":16448,"DIRECTION":"BI","MASTER_ID":16445,"compounds":"(2R,3S)-2,4',7-trihydroxyisoflavanone <=> daidzein + H(+) + H2O","pmd":18.011}
{"X":5245,"KEGG":"R07319","RHEA_ID":21231,"DIRECTION":"BI","MASTER_ID":21228,"metacyc":"5.1.3.21-RXN","compounds":"alpha-maltose <=> beta-maltose","pmd":0}
{"X":5246,"KEGG":"R07320","RHEA_ID":21755,"DIRECTION":"BI","MASTER_ID":21752,"compounds":"all-trans-violaxanthin <=> all-trans-capsorubin","pmd":0}
{"X":5247,"KEGG":"R07321","RHEA_ID":17376,"DIRECTION":"BI","MASTER_ID":17373,"compounds":"all-trans-antheraxanthin <=> all-trans-capsanthin","pmd":0}
{"X":5248,"KEGG":"R07322","RHEA_ID":17640,"DIRECTION":"BI","MASTER_ID":17637,"compounds":"squalene <=> hop-22(29)-ene","pmd":0}
{"X":5249,"KEGG":"R07323","RHEA_ID":16564,"DIRECTION":"BI","MASTER_ID":16561,"compounds":"H2O + squalene <=> hopan-22-ol","pmd":18.01}
{"X":5250,"KEGG":"R07324","RHEA_ID":10719,"DIRECTION":"BI","MASTER_ID":10716,"compounds":"D-glucose 6-phosphate <=> 1D-myo-inositol 3-phosphate","pmd":0}
{"X":5251,"KEGG":"R07325","RHEA_ID":22663,"DIRECTION":"BI","MASTER_ID":22660,"compounds":"a fatty acid + ATP + holo-[ACP] <=> a fatty acyl-[ACP] + AMP + diphosphate","pmd":159.933}
{"X":5252,"KEGG":"R07328","RHEA_ID":15940,"DIRECTION":"BI","MASTER_ID":15937,"compounds":"a primary alcohol + NADP(+) <=> an aldehyde + H(+) + NADPH"}
{"X":5253,"KEGG":"R07329","RHEA_ID":18624,"DIRECTION":"BI","MASTER_ID":18621,"compounds":"2-oxoglutarate + a (2S)-flavan-4-one + O2 <=> a (2R,3R)-dihydroflavonol + CO2 + succinate","pmd":27.995}
{"X":5254,"KEGG":"R07329","RHEA_ID":18624,"DIRECTION":"BI","MASTER_ID":18621,"compounds":"2-oxoglutarate + a (2S)-flavan-4-one + O2 <=> a (2R,3R)-dihydroflavonol + CO2 + succinate","pmd":15.995}
{"X":5255,"KEGG":"R07330","RHEA_ID":17880,"DIRECTION":"BI","MASTER_ID":17877,"compounds":"a catechol + S-adenosyl-L-methionine <=> a guaiacol + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5256,"KEGG":"R07332","RHEA_ID":56347,"DIRECTION":"BI","MASTER_ID":56344,"compounds":"a 7-hydroxyisoflavone + UDP-alpha-D-glucose <=> a 7-hydroxyisoflavone 7-O-beta-D-glucoside + H(+) + UDP","pmd":162.053}
{"X":5257,"KEGG":"R07332","RHEA_ID":56347,"DIRECTION":"BI","MASTER_ID":56344,"compounds":"a 7-hydroxyisoflavone + UDP-alpha-D-glucose <=> a 7-hydroxyisoflavone 7-O-beta-D-glucoside + H(+) + UDP","pmd":178.048}
{"X":5258,"KEGG":"R07334","RHEA_ID":16216,"DIRECTION":"BI","MASTER_ID":16213,"compounds":"3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP","pmd":203.079}
{"X":5259,"KEGG":"R07335","RHEA_ID":20911,"DIRECTION":"BI","MASTER_ID":20908,"compounds":"3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-alpha-D-glucuronate <=> 3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n+1)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP","pmd":176.032}
{"X":5260,"KEGG":"R07337","RHEA_ID":15476,"DIRECTION":"BI","MASTER_ID":15473,"metacyc":"RXN-5001","compounds":"flavanone 7-O-beta-D-glucoside + UDP-beta-L-rhamnose <=> flavanone 7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucoside] + H(+) + UDP","pmd":1.871}
{"X":5261,"KEGG":"R07338","RHEA_ID":23167,"DIRECTION":"BI","MASTER_ID":23164,"compounds":"a 7-O-hydroxy-flavonol + UDP-alpha-D-glucose <=> a flavonol 7-O-beta-D-glucoside + H(+) + UDP","pmd":149.944}
{"X":5262,"KEGG":"R07338","RHEA_ID":23167,"DIRECTION":"BI","MASTER_ID":23164,"compounds":"a 7-O-hydroxy-flavonol + UDP-alpha-D-glucose <=> a flavonol 7-O-beta-D-glucoside + H(+) + UDP","pmd":165.939}
{"X":5263,"KEGG":"R07339","RHEA_ID":18896,"DIRECTION":"BI","MASTER_ID":18893,"compounds":"a flavonol 3-O-beta-D-glucoside + UDP-alpha-D-glucose <=> a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP","pmd":3.886}
{"X":5264,"KEGG":"R07340","RHEA_ID":23547,"DIRECTION":"BI","MASTER_ID":23544,"compounds":"a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-alpha-D-glucose <=> a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP","pmd":158.167}
{"X":5265,"KEGG":"R07340","RHEA_ID":23547,"DIRECTION":"BI","MASTER_ID":23544,"compounds":"a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-alpha-D-glucose <=> a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP","pmd":158.166}
{"X":5266,"KEGG":"R07341","RHEA_ID":19964,"DIRECTION":"BI","MASTER_ID":19961,"compounds":"a 2'-deoxyribonucleoside + a ribonucleoside 5'-phosphate <=> a 2'-deoxyribonucleoside 5'-phosphate + a ribonucleoside"}
{"X":5267,"KEGG":"R07342","RHEA_ID":17312,"DIRECTION":"BI","MASTER_ID":17309,"compounds":"a phenyl acetate + H2O <=> a phenol + acetate + H(+)"}
{"X":5268,"KEGG":"R07343","RHEA_ID":24059,"DIRECTION":"BI","MASTER_ID":24056,"compounds":"a myo-inositol phosphate + H2O <=> myo-inositol + phosphate"}
{"X":5269,"KEGG":"R07345","RHEA_ID":21879,"DIRECTION":"BI","MASTER_ID":21876,"compounds":"(6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD(+) <=> (S)-usnate + 2 H(+) + NADH","pmd":2.016}
{"X":5270,"KEGG":"R07345","RHEA_ID":21879,"DIRECTION":"BI","MASTER_ID":21876,"compounds":"(6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD(+) <=> (S)-usnate + 2 H(+) + NADH","pmd":319.02}
{"X":5271,"KEGG":"R07346","RHEA_ID":14612,"DIRECTION":"BI","MASTER_ID":14609,"metacyc":"1.1.1.289-RXN","compounds":"D-sorbitol + NADP(+) <=> H(+) + keto-L-sorbose + NADPH","pmd":564.02}
{"X":5272,"KEGG":"R07346","RHEA_ID":14612,"DIRECTION":"BI","MASTER_ID":14609,"metacyc":"1.1.1.289-RXN","compounds":"D-sorbitol + NADP(+) <=> H(+) + keto-L-sorbose + NADPH","pmd":2.016}
{"X":5273,"KEGG":"R07349","RHEA_ID":13736,"DIRECTION":"BI","MASTER_ID":13733,"compounds":"an n-alkanal + NAD(+) <=> an alk-2-enal + H(+) + NADH"}
{"X":5274,"KEGG":"R07350","RHEA_ID":13740,"DIRECTION":"BI","MASTER_ID":13737,"compounds":"an n-alkanal + NADP(+) <=> an alk-2-enal + H(+) + NADPH"}
{"X":5275,"KEGG":"R07351","RHEA_ID":11643,"DIRECTION":"BI","MASTER_ID":11640,"compounds":"a (2R,3R)-flavan-3-ol + 2 NAD(+) <=> an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADH","pmd":441.041}
{"X":5276,"KEGG":"R07352","RHEA_ID":11647,"DIRECTION":"BI","MASTER_ID":11644,"compounds":"a (2R,3R)-flavan-3-ol + 2 NADP(+) <=> an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH","pmd":521.007}
{"X":5277,"KEGG":"R07353","RHEA_ID":10695,"DIRECTION":"BI","MASTER_ID":10692,"metacyc":"1.3.3.11-RXN","compounds":"6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 <=> H(+) + 2 H2O + 2 H2O2 + pyrroloquinoline quinone","pmd":8.063}
{"X":5278,"KEGG":"R07354","RHEA_ID":17872,"DIRECTION":"BI","MASTER_ID":17869,"compounds":"5,6,7,8-tetrahydropteridine + NAD(+) <=> 6,7-dihydropteridine + H(+) + NADH","pmd":530.058}
{"X":5279,"KEGG":"R07354","RHEA_ID":17872,"DIRECTION":"BI","MASTER_ID":17869,"compounds":"5,6,7,8-tetrahydropteridine + NAD(+) <=> 6,7-dihydropteridine + H(+) + NADH","pmd":2.016}
{"X":5280,"KEGG":"R07354","RHEA_ID":17868,"DIRECTION":"BI","MASTER_ID":17865,"compounds":"5,6,7,8-tetrahydropteridine + NADP(+) <=> 6,7-dihydropteridine + H(+) + NADPH","pmd":530.058}
{"X":5281,"KEGG":"R07354","RHEA_ID":17868,"DIRECTION":"BI","MASTER_ID":17865,"compounds":"5,6,7,8-tetrahydropteridine + NADP(+) <=> 6,7-dihydropteridine + H(+) + NADPH","pmd":2.016}
{"X":5282,"KEGG":"R07358","RHEA_ID":46163,"DIRECTION":"BI","MASTER_ID":46160,"metacyc":"1.6.99.5-RXN","compounds":"a quinone + H(+) + NADH <=> a quinol + NAD(+)"}
{"X":5283,"KEGG":"R07359","RHEA_ID":46167,"DIRECTION":"BI","MASTER_ID":46164,"compounds":"a quinone + H(+) + NADPH <=> a quinol + NADP(+)"}
{"X":5284,"KEGG":"R07360","RHEA_ID":53895,"DIRECTION":"BI","MASTER_ID":53892,"compounds":"an S-prenyl-L-cysteine + H2O + O2 <=> a prenal + H2O2 + L-cysteine"}
{"X":5285,"KEGG":"R07361","RHEA_ID":12367,"DIRECTION":"BI","MASTER_ID":12364,"metacyc":"1.10.99.2-RXN","compounds":"1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) <=> a quinol + beta-nicotinamide D-riboside"}
{"X":5286,"KEGG":"R07362","RHEA_ID":14192,"DIRECTION":"BI","MASTER_ID":14189,"compounds":"D-tryptophan + O2 <=> N-formyl-D-kynurenine","pmd":31.99}
{"X":5287,"KEGG":"R07363","RHEA_ID":14164,"DIRECTION":"BI","MASTER_ID":14161,"compounds":"1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 <=> 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)","pmd":42.011}
{"X":5288,"KEGG":"R07364","RHEA_ID":24507,"DIRECTION":"BI","MASTER_ID":24504,"compounds":"1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 <=> 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)","pmd":14.016}
{"X":5289,"KEGG":"R07365","RHEA_ID":13960,"DIRECTION":"BI","MASTER_ID":13957,"compounds":"4 H2O + O2 + 4 sulfur <=> 6 H(+) + 2 hydrogen sulfide + 2 sulfite"}
{"X":5290,"KEGG":"R07366","RHEA_ID":10771,"DIRECTION":"BI","MASTER_ID":10768,"compounds":"(2R,3S,4S)-3,4-leucopelargonidin + 2-oxoglutarate + O2 <=> (4S)-2,3-dehydroleucopelargonidin + CO2 + H(+) + H2O + succinate","pmd":27.995}
{"X":5291,"KEGG":"R07366","RHEA_ID":10771,"DIRECTION":"BI","MASTER_ID":10768,"compounds":"(2R,3S,4S)-3,4-leucopelargonidin + 2-oxoglutarate + O2 <=> (4S)-2,3-dehydroleucopelargonidin + CO2 + H(+) + H2O + succinate","pmd":2.016}
{"X":5292,"KEGG":"R07367","RHEA_ID":10451,"DIRECTION":"BI","MASTER_ID":10448,"compounds":"2-oxoglutarate + a flavanone + O2 <=> a flavone + CO2 + H2O + succinate","pmd":27.995}
{"X":5293,"KEGG":"R07367","RHEA_ID":10451,"DIRECTION":"BI","MASTER_ID":10448,"compounds":"2-oxoglutarate + a flavanone + O2 <=> a flavone + CO2 + H2O + succinate","pmd":2.016}
{"X":5294,"KEGG":"R07368","RHEA_ID":21091,"DIRECTION":"BI","MASTER_ID":21088,"compounds":"2-oxoglutarate + a (2R,3R)-dihydroflavonol + O2 <=> a flavonol + CO2 + H2O + succinate","pmd":2.016}
{"X":5295,"KEGG":"R07368","RHEA_ID":21091,"DIRECTION":"BI","MASTER_ID":21088,"compounds":"2-oxoglutarate + a (2R,3R)-dihydroflavonol + O2 <=> a flavonol + CO2 + H2O + succinate","pmd":27.995}
{"X":5296,"KEGG":"R07369","RHEA_ID":10595,"DIRECTION":"BI","MASTER_ID":10592,"compounds":"a 3',5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase] <=> a 3'-hydroxy,5'-unsubstituted flavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":5297,"KEGG":"R07370","RHEA_ID":18800,"DIRECTION":"BI","MASTER_ID":18797,"compounds":"a 3'-hydroxy,5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase] <=> a 3',5'-dihydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":5298,"KEGG":"R07371","RHEA_ID":18852,"DIRECTION":"BI","MASTER_ID":18849,"compounds":"a 2'-unsubstituted isoflavone + O2 + reduced [NADPH--hemoprotein reductase] <=> a 2'-hydroxyisoflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":5299,"KEGG":"R07372","RHEA_ID":19044,"DIRECTION":"BI","MASTER_ID":19041,"compounds":"(25R)-cholest-5-ene-3beta,26-diol + O2 + reduced [NADPH--hemoprotein reductase] <=> (25R)-cholest-5-en-3beta,7alpha,26-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":5300,"KEGG":"R07373","RHEA_ID":11423,"DIRECTION":"BI","MASTER_ID":11420,"compounds":"NADPH + O2 + senecionine <=> H2O + NADP(+) + senecionine N-oxide","pmd":393.923}
{"X":5301,"KEGG":"R07373","RHEA_ID":11423,"DIRECTION":"BI","MASTER_ID":11420,"compounds":"NADPH + O2 + senecionine <=> H2O + NADP(+) + senecionine N-oxide","pmd":15.995}
{"X":5302,"KEGG":"R07374","RHEA_ID":15736,"DIRECTION":"BI","MASTER_ID":15733,"metacyc":"1.17.99.3-RXN","compounds":"(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + A + H2O <=> (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + AH2"}
{"X":5303,"KEGG":"R07375","RHEA_ID":17936,"DIRECTION":"BI","MASTER_ID":17933,"compounds":"a 7-hydroxyisoflavone + S-adenosyl-L-methionine <=> a 7-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5304,"KEGG":"R07376","RHEA_ID":27609,"DIRECTION":"BI","MASTER_ID":27606,"metacyc":"RXN-1382","compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine <=> 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine"}
{"X":5305,"KEGG":"R07379","RHEA_ID":36198,"DIRECTION":"BI","MASTER_ID":36195,"compounds":"1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + a carboxylate + H(+)"}
{"X":5306,"KEGG":"R07380","RHEA_ID":36202,"DIRECTION":"BI","MASTER_ID":36199,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-(1Z-alkenyl)-sn-glycerol + H(+) + phosphoethanolamine"}
{"X":5307,"KEGG":"R07380","RHEA_ID":36222,"DIRECTION":"BI","MASTER_ID":36219,"compounds":"1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + ethanolamine + H(+)"}
{"X":5308,"KEGG":"R07381","RHEA_ID":36226,"DIRECTION":"BI","MASTER_ID":36223,"compounds":"1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + H(+) + phosphoethanolamine"}
{"X":5309,"KEGG":"R07382","RHEA_ID":36210,"DIRECTION":"BI","MASTER_ID":36207,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an acyl-CoA <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + CoA"}
{"X":5310,"KEGG":"R07383","RHEA_ID":36214,"DIRECTION":"BI","MASTER_ID":36211,"compounds":"1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + H2O <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + phosphate"}
{"X":5311,"KEGG":"R07384","RHEA_ID":36218,"DIRECTION":"BI","MASTER_ID":36215,"compounds":"1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-ethanolamine <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)","pmd":123.009}
{"X":5312,"KEGG":"R07386","RHEA_ID":36194,"DIRECTION":"BI","MASTER_ID":36191,"compounds":"1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + choline <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + ethanolamine"}
{"X":5313,"KEGG":"R07387","RHEA_ID":36234,"DIRECTION":"BI","MASTER_ID":36231,"compounds":"1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)"}
{"X":5314,"KEGG":"R07388","RHEA_ID":36206,"DIRECTION":"BI","MASTER_ID":36203,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + ethanolamine + H(+)"}
{"X":5315,"KEGG":"R07389","RHEA_ID":36182,"DIRECTION":"BI","MASTER_ID":36179,"compounds":"1-O-alkyl-2-acyl-sn-glycerol + CDP-choline <=> 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)","pmd":165.055}
{"X":5316,"KEGG":"R07390","RHEA_ID":31454,"DIRECTION":"BI","MASTER_ID":31451,"compounds":"2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> a cardiolipin + glycerol"}
{"X":5317,"KEGG":"R07392","RHEA_ID":15552,"DIRECTION":"BI","MASTER_ID":15549,"compounds":"5-methylsulfanyl-D-ribulose 1-phosphate <=> 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O","pmd":18.011}
{"X":5318,"KEGG":"R07393","RHEA_ID":18772,"DIRECTION":"BI","MASTER_ID":18769,"compounds":"5-methylsulfanyl-2,3-dioxopentyl phosphate <=> 2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate","pmd":0}
{"X":5319,"KEGG":"R07394","RHEA_ID":14484,"DIRECTION":"BI","MASTER_ID":14481,"compounds":"2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate + H2O <=> 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate","pmd":79.966}
{"X":5320,"KEGG":"R07395","RHEA_ID":21703,"DIRECTION":"BI","MASTER_ID":21700,"compounds":"5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O <=> 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate","pmd":79.966}
{"X":5321,"KEGG":"R07396","RHEA_ID":25799,"DIRECTION":"BI","MASTER_ID":25796,"metacyc":"RXN-14147","compounds":"2-oxoglutarate + L-methionine <=> 4-methylsulfanyl-2-oxobutanoate + L-glutamate","pmd":1.032}
{"X":5322,"KEGG":"R07397","RHEA_ID":16224,"DIRECTION":"BI","MASTER_ID":16221,"compounds":"3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP","pmd":203.079}
{"X":5323,"KEGG":"R07398","RHEA_ID":10835,"DIRECTION":"BI","MASTER_ID":10832,"compounds":"a 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O <=> 6-(alpha-D-glucosaminyl)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphate + H(+)"}
{"X":5324,"KEGG":"R07399","RHEA_ID":19048,"DIRECTION":"BI","MASTER_ID":19045,"compounds":"acetyl-CoA + H2O + pyruvate <=> (3R)-citramalate + CoA + H(+)","pmd":42.011}
{"X":5325,"KEGG":"R07402","RHEA_ID":23511,"DIRECTION":"BI","MASTER_ID":23508,"metacyc":"3.5.1.93-RXN","compounds":"(7R)-7-(4-carboxybutanamido)cephalosporanate + H2O <=> (7R)-7-aminocephalosporanate + glutarate","pmd":114.032}
{"X":5326,"KEGG":"R07403","RHEA_ID":31902,"DIRECTION":"BI","MASTER_ID":31899,"compounds":"indole + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + indolin-2-one + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":5327,"KEGG":"R07404","RHEA_ID":19320,"DIRECTION":"BI","MASTER_ID":19317,"compounds":"5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate <=> 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate","pmd":43.99}
{"X":5328,"KEGG":"R07404","RHEA_ID":19320,"DIRECTION":"BI","MASTER_ID":19317,"compounds":"5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate <=> 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate","pmd":79.966}
{"X":5329,"KEGG":"R07405","RHEA_ID":13196,"DIRECTION":"BI","MASTER_ID":13193,"compounds":"5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) <=> 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate","pmd":0}
{"X":5330,"KEGG":"R07406","RHEA_ID":25142,"DIRECTION":"BI","MASTER_ID":25139,"compounds":"(2S)-2-amino-3-oxo-4-(phosphooxy)butanoate + H(+) <=> 3-amino-2-oxopropyl phosphate + CO2","pmd":43.99}
{"X":5331,"KEGG":"R07407","RHEA_ID":42447,"DIRECTION":"BI","MASTER_ID":42444,"compounds":"L-aspartate + NADP(+) <=> H(+) + iminosuccinate + NADPH","pmd":2.016}
{"X":5332,"KEGG":"R07407","RHEA_ID":42447,"DIRECTION":"BI","MASTER_ID":42444,"compounds":"L-aspartate + NADP(+) <=> H(+) + iminosuccinate + NADPH","pmd":613.061}
{"X":5333,"KEGG":"R07408","RHEA_ID":22591,"DIRECTION":"BI","MASTER_ID":22588,"ecocyc":"RXN-6423","metacyc":"RXN-6423","compounds":"4-aminobutanal <=> 1-pyrroline + H2O"}
{"X":5334,"KEGG":"R07409","RHEA_ID":17772,"DIRECTION":"BI","MASTER_ID":17769,"compounds":"choline + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> betaine aldehyde hydrate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]","pmd":2.016}
{"X":5335,"KEGG":"R07410","RHEA_ID":42443,"DIRECTION":"BI","MASTER_ID":42440,"compounds":"L-aspartate + NAD(+) <=> H(+) + iminosuccinate + NADH","pmd":533.095}
{"X":5336,"KEGG":"R07410","RHEA_ID":42443,"DIRECTION":"BI","MASTER_ID":42440,"compounds":"L-aspartate + NAD(+) <=> H(+) + iminosuccinate + NADH","pmd":2.016}
{"X":5337,"KEGG":"R07411","RHEA_ID":28073,"DIRECTION":"BI","MASTER_ID":28070,"compounds":"(2E,6E)-farnesyl diphosphate + H2O + heme b <=> diphosphate + Fe(II)-heme o","pmd":222.198}
{"X":5338,"KEGG":"R07411","RHEA_ID":28073,"DIRECTION":"BI","MASTER_ID":28070,"compounds":"(2E,6E)-farnesyl diphosphate + H2O + heme b <=> diphosphate + Fe(II)-heme o","pmd":456.245}
{"X":5339,"KEGG":"R07414","RHEA_ID":13636,"DIRECTION":"BI","MASTER_ID":13633,"compounds":"ATP + L-glutamate + putrescine <=> ADP + gamma-L-glutamylputrescine + H(+) + phosphate","pmd":70.089}
{"X":5340,"KEGG":"R07414","RHEA_ID":13636,"DIRECTION":"BI","MASTER_ID":13633,"compounds":"ATP + L-glutamate + putrescine <=> ADP + gamma-L-glutamylputrescine + H(+) + phosphate","pmd":79.966}
{"X":5341,"KEGG":"R07415","RHEA_ID":28417,"DIRECTION":"BI","MASTER_ID":28414,"compounds":"gamma-L-glutamylputrescine + H2O + O2 <=> 4-(gamma-L-glutamylamino)butanal + H2O2 + NH4(+)","pmd":1.032}
{"X":5342,"KEGG":"R07417","RHEA_ID":42343,"DIRECTION":"BI","MASTER_ID":42340,"compounds":"4-(gamma-L-glutamylamino)butanal + H2O + NAD(+) <=> 4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADH","pmd":15.995}
{"X":5343,"KEGG":"R07417","RHEA_ID":42343,"DIRECTION":"BI","MASTER_ID":42340,"compounds":"4-(gamma-L-glutamylamino)butanal + H2O + NAD(+) <=> 4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADH","pmd":432.011}
{"X":5344,"KEGG":"R07418","RHEA_ID":28413,"DIRECTION":"BI","MASTER_ID":28410,"compounds":"4-(gamma-L-glutamylamino)butanal + H2O + NADP(+) <=> 4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADPH","pmd":511.977}
{"X":5345,"KEGG":"R07418","RHEA_ID":28413,"DIRECTION":"BI","MASTER_ID":28410,"compounds":"4-(gamma-L-glutamylamino)butanal + H2O + NADP(+) <=> 4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADPH","pmd":15.995}
{"X":5346,"KEGG":"R07419","RHEA_ID":19740,"DIRECTION":"BI","MASTER_ID":19737,"compounds":"4-(gamma-L-glutamylamino)butanoate + H2O <=> 4-aminobutanoate + L-glutamate","pmd":85.053}
{"X":5347,"KEGG":"R07421","RHEA_ID":31922,"DIRECTION":"BI","MASTER_ID":31919,"compounds":"indolin-2-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-hydroxyindolin-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":5348,"KEGG":"R07422","RHEA_ID":31930,"DIRECTION":"BI","MASTER_ID":31927,"compounds":"3-hydroxyindolin-2-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":5349,"KEGG":"R07423","RHEA_ID":31942,"DIRECTION":"BI","MASTER_ID":31939,"compounds":"2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + O2 + reduced [NADPH--hemoprotein reductase] <=> DIBOA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":5350,"KEGG":"R07426","RHEA_ID":33958,"DIRECTION":"BI","MASTER_ID":33955,"compounds":"DIBOA + UDP-alpha-D-glucose <=> DIBOA beta-D-glucoside + H(+) + UDP","pmd":162.053}
{"X":5351,"KEGG":"R07429","RHEA_ID":54419,"DIRECTION":"BI","MASTER_ID":54416,"compounds":"5alpha-campestan-3-one + NADP(+) <=> campest-4-en-3-one + H(+) + NADPH","pmd":344.721}
{"X":5352,"KEGG":"R07429","RHEA_ID":54419,"DIRECTION":"BI","MASTER_ID":54416,"compounds":"5alpha-campestan-3-one + NADP(+) <=> campest-4-en-3-one + H(+) + NADPH","pmd":2.016}
{"X":5353,"KEGG":"R07437","RHEA_ID":45727,"DIRECTION":"BI","MASTER_ID":45724,"compounds":"(E)-4-coumaroyl alcohol + NADP(+) <=> (E)-4-coumaraldehyde + H(+) + NADPH","pmd":595.023}
{"X":5354,"KEGG":"R07437","RHEA_ID":45727,"DIRECTION":"BI","MASTER_ID":45724,"compounds":"(E)-4-coumaroyl alcohol + NADP(+) <=> (E)-4-coumaraldehyde + H(+) + NADPH","pmd":2.016}
{"X":5355,"KEGG":"R07459","RHEA_ID":43347,"DIRECTION":"BI","MASTER_ID":43344,"compounds":"[sulfur-carrier protein ThiS]-C-terminal Gly-Gly + ATP + H(+) <=> [sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + diphosphate"}
{"X":5356,"KEGG":"R07459","RHEA_ID":43619,"DIRECTION":"BI","MASTER_ID":43616,"compounds":"[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) <=> [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate"}
{"X":5357,"KEGG":"R07460","RHEA_ID":17460,"DIRECTION":"BI","MASTER_ID":17457,"compounds":"[sulfur-carrier protein]-L-cysteine + L-cysteine <=> [sulfur-carrier protein]-S-sulfanyl-L-cysteine + L-alanine"}
{"X":5358,"KEGG":"R07463","RHEA_ID":33346,"DIRECTION":"BI","MASTER_ID":33343,"compounds":"glycine + O2 <=> 2-iminoacetate + H2O2"}
{"X":5359,"KEGG":"R07475","RHEA_ID":25697,"DIRECTION":"BI","MASTER_ID":25694,"metacyc":"RXN-8813","compounds":"all-trans-geranylgeranyl diphosphate + isopentenyl diphosphate <=> (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate","pmd":68.063}
{"X":5360,"KEGG":"R07475","RHEA_ID":25697,"DIRECTION":"BI","MASTER_ID":25694,"metacyc":"RXN-8813","compounds":"all-trans-geranylgeranyl diphosphate + isopentenyl diphosphate <=> (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate","pmd":272.25}
{"X":5361,"KEGG":"R07476","RHEA_ID":22787,"DIRECTION":"BI","MASTER_ID":22784,"compounds":"(2R)-O-phospho-3-sulfolactate <=> H(+) + phosphoenolpyruvate + sulfite","pmd":81.972}
{"X":5362,"KEGG":"R07477","RHEA_ID":19908,"DIRECTION":"BI","MASTER_ID":19905,"compounds":"NAD(+) + spermidine <=> dehydrospermidine + H(+) + NADH","pmd":2.016}
{"X":5363,"KEGG":"R07477","RHEA_ID":19908,"DIRECTION":"BI","MASTER_ID":19905,"compounds":"NAD(+) + spermidine <=> dehydrospermidine + H(+) + NADH","pmd":520.975}
{"X":5364,"KEGG":"R07478","RHEA_ID":52999,"DIRECTION":"BI","MASTER_ID":52996,"compounds":"[eIF5A protein]-N-(4-aminobutylidene)-L-lysine + H(+) + NADH <=> [eIF5A protein]-deoxyhypusine + NAD(+)"}
{"X":5365,"KEGG":"R07479","RHEA_ID":10907,"DIRECTION":"BI","MASTER_ID":10904,"metacyc":"RXN-15241","compounds":"[cypemycin](1-18)-L-Cys-L-Leu-L-Val-L-Cys + A <=> AH2 + C(3,19),S(21)-[cypemycin](1-18)-L-Ala-L-Leu-N-thioethenyl-L-valinamide + CO2 + hydrogen sulfide"}
{"X":5366,"KEGG":"R07479","RHEA_ID":52991,"DIRECTION":"BI","MASTER_ID":52988,"compounds":"[deoxyhypusine synthase]-L-lysine + dehydrospermidine <=> [deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + propane-1,3-diamine"}
{"X":5367,"KEGG":"R07480","RHEA_ID":52995,"DIRECTION":"BI","MASTER_ID":52992,"compounds":"[deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + [eIF5A protein]-L-lysine <=> [deoxyhypusine synthase]-L-lysine + [eIF5A protein]-N-(4-aminobutylidene)-L-lysine"}
{"X":5368,"KEGG":"R07489","RHEA_ID":46579,"DIRECTION":"BI","MASTER_ID":46576,"compounds":"(24R)-ethylcholest-5-en-3beta-ol + H(+) + NADPH + O2 <=> 2 H2O + NADP(+) + stigmasterol","pmd":332.721}
{"X":5369,"KEGG":"R07489","RHEA_ID":46579,"DIRECTION":"BI","MASTER_ID":46576,"compounds":"(24R)-ethylcholest-5-en-3beta-ol + H(+) + NADPH + O2 <=> 2 H2O + NADP(+) + stigmasterol","pmd":2.016}
{"X":5370,"KEGG":"R07491","RHEA_ID":46563,"DIRECTION":"BI","MASTER_ID":46560,"compounds":"2 [Fe(II)-cytochrome b5] + episterol + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + ergosta-5,7,24(28)-trien-3beta-ol + 2 H2O","pmd":2.016}
{"X":5371,"KEGG":"R07494","RHEA_ID":33450,"DIRECTION":"BI","MASTER_ID":33447,"compounds":"4alpha-carboxyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) <=> 4-methyl-5alpha-cholesta-8,24-dien-3-one + CO2 + NADPH","pmd":347.744}
{"X":5372,"KEGG":"R07494","RHEA_ID":33450,"DIRECTION":"BI","MASTER_ID":33447,"compounds":"4alpha-carboxyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) <=> 4-methyl-5alpha-cholesta-8,24-dien-3-one + CO2 + NADPH","pmd":46.005}
{"X":5373,"KEGG":"R07495","RHEA_ID":36382,"DIRECTION":"BI","MASTER_ID":36379,"compounds":"4alpha-methyl-5alpha-cholesta-8,24-dien-3-one + H(+) + NADPH <=> 4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+)","pmd":2.016}
{"X":5374,"KEGG":"R07495","RHEA_ID":36382,"DIRECTION":"BI","MASTER_ID":36379,"compounds":"4alpha-methyl-5alpha-cholesta-8,24-dien-3-one + H(+) + NADPH <=> 4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+)","pmd":346.736}
{"X":5375,"KEGG":"R07496","RHEA_ID":42459,"DIRECTION":"BI","MASTER_ID":42456,"compounds":"4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol <=> 5alpha-cholesta-8,24-dien-3beta-ol"}
{"X":5376,"KEGG":"R07497","RHEA_ID":33438,"DIRECTION":"BI","MASTER_ID":33435,"compounds":"24-methylene-5alpha-cholest-8-en-3beta-ol <=> episterol","pmd":0}
{"X":5377,"KEGG":"R07498","RHEA_ID":36402,"DIRECTION":"BI","MASTER_ID":36399,"compounds":"5alpha-cholest-8-en-3beta-ol + NADP(+) <=> 5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADPH","pmd":2.016}
{"X":5378,"KEGG":"R07498","RHEA_ID":36402,"DIRECTION":"BI","MASTER_ID":36399,"compounds":"5alpha-cholest-8-en-3beta-ol + NADP(+) <=> 5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADPH","pmd":358.736}
{"X":5379,"KEGG":"R07500","RHEA_ID":37978,"DIRECTION":"BI","MASTER_ID":37975,"compounds":"H(+) + homogentisate + phytyl diphosphate <=> 2-methyl-6-phytyl-1,4-benzene-1,4-diol + CO2 + diphosphate","pmd":234.308}
{"X":5380,"KEGG":"R07500","RHEA_ID":37978,"DIRECTION":"BI","MASTER_ID":37975,"compounds":"H(+) + homogentisate + phytyl diphosphate <=> 2-methyl-6-phytyl-1,4-benzene-1,4-diol + CO2 + diphosphate","pmd":53.891}
{"X":5381,"KEGG":"R07501","RHEA_ID":37982,"DIRECTION":"BI","MASTER_ID":37979,"compounds":"2-methyl-6-phytyl-1,4-benzene-1,4-diol + S-adenosyl-L-methionine <=> 2,3-dimethyl-6-phytylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5382,"KEGG":"R07502","RHEA_ID":37986,"DIRECTION":"BI","MASTER_ID":37983,"compounds":"gamma-tocopherol <=> 2,3-dimethyl-6-phytylbenzene-1,4-diol","pmd":0}
{"X":5383,"KEGG":"R07503","RHEA_ID":37990,"DIRECTION":"BI","MASTER_ID":37987,"compounds":"delta-tocopherol <=> 2-methyl-6-phytyl-1,4-benzene-1,4-diol","pmd":0}
{"X":5384,"KEGG":"R07504","RHEA_ID":37994,"DIRECTION":"BI","MASTER_ID":37991,"compounds":"delta-tocopherol + S-adenosyl-L-methionine <=> beta-tocopherol + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5385,"KEGG":"R07505","RHEA_ID":33466,"DIRECTION":"BI","MASTER_ID":33463,"compounds":"episterol + H(+) + NADPH + O2 <=> ergosta-5,7,24(28)-trien-3beta-ol + 2 H2O + NADP(+)","pmd":2.016}
{"X":5386,"KEGG":"R07506","RHEA_ID":33470,"DIRECTION":"BI","MASTER_ID":33467,"compounds":"ergosta-5,7,24(28)-trien-3beta-ol + H(+) + NADPH + O2 <=> ergosta-5,7,22,24(28)-tetraen-3beta-ol + 2 H2O + NADP(+)","pmd":350.767}
{"X":5387,"KEGG":"R07506","RHEA_ID":33470,"DIRECTION":"BI","MASTER_ID":33467,"compounds":"ergosta-5,7,24(28)-trien-3beta-ol + H(+) + NADPH + O2 <=> ergosta-5,7,22,24(28)-tetraen-3beta-ol + 2 H2O + NADP(+)","pmd":2.016}
{"X":5388,"KEGG":"R07507","RHEA_ID":36398,"DIRECTION":"BI","MASTER_ID":36395,"compounds":"cholesta-5,7-dien-3beta-ol + NADP(+) <=> cholesta-5,7,24-trien-3beta-ol + H(+) + NADPH","pmd":360.752}
{"X":5389,"KEGG":"R07507","RHEA_ID":36398,"DIRECTION":"BI","MASTER_ID":36395,"compounds":"cholesta-5,7-dien-3beta-ol + NADP(+) <=> cholesta-5,7,24-trien-3beta-ol + H(+) + NADPH","pmd":2.016}
{"X":5390,"KEGG":"R07511","RHEA_ID":30958,"DIRECTION":"BI","MASTER_ID":30955,"metacyc":"RXN-12242","compounds":"9,9'-di-cis-zeta-carotene + 2 a quinone <=> 7,7',9,9'-tetra-cis-lycopene + 2 a quinol","pmd":4.031}
{"X":5391,"KEGG":"R07512","RHEA_ID":30974,"DIRECTION":"BI","MASTER_ID":30971,"compounds":"7,7',9,9'-tetra-cis-lycopene <=> all-trans-lycopene","pmd":0}
{"X":5392,"KEGG":"R07513","RHEA_ID":22127,"DIRECTION":"BI","MASTER_ID":22124,"compounds":"17-O-acetylajmaline + H2O <=> acetate + ajmaline + H(+)","pmd":42.011}
{"X":5393,"KEGG":"R07514","RHEA_ID":34226,"DIRECTION":"BI","MASTER_ID":34223,"compounds":"6-hydroxypseudooxynicotine + A + H2O <=> 2,6-dihydroxypseudooxynicotine + AH2","pmd":15.995}
{"X":5394,"KEGG":"R07515","RHEA_ID":34170,"DIRECTION":"BI","MASTER_ID":34167,"compounds":"2,6-dihydroxypseudooxynicotine + H2O <=> 2,6-dihydroxypyridine + 4-(methylamino)butanoate + H(+)","pmd":93.021}
{"X":5395,"KEGG":"R07517","RHEA_ID":59335,"DIRECTION":"BI","MASTER_ID":59332,"compounds":"1'-hydroxy-gamma-carotene + A <=> 1'-hydroxytorulene + AH2","pmd":2.016}
{"X":5396,"KEGG":"R07518","RHEA_ID":30982,"DIRECTION":"BI","MASTER_ID":30979,"compounds":"A + all-trans-lycopene <=> AH2 + all-trans-3,4-didehydrolycopene","pmd":2.016}
{"X":5397,"KEGG":"R07519","RHEA_ID":31610,"DIRECTION":"BI","MASTER_ID":31607,"compounds":"rhodopin <=> all-trans-lycopene + H2O","pmd":18.011}
{"X":5398,"KEGG":"R07520","RHEA_ID":30922,"DIRECTION":"BI","MASTER_ID":30919,"compounds":"A + rhodopin <=> (3E)-3,4-didehydrorhodopin + AH2","pmd":2.016}
{"X":5399,"KEGG":"R07525","RHEA_ID":33042,"DIRECTION":"BI","MASTER_ID":33039,"compounds":"4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin <=> 2-oxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]","pmd":13.979}
{"X":5400,"KEGG":"R07526","RHEA_ID":33038,"DIRECTION":"BI","MASTER_ID":33035,"compounds":"2-oxospirilloxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> 2,2'-dioxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]","pmd":13.979}
{"X":5401,"KEGG":"R07531","RHEA_ID":57355,"DIRECTION":"BI","MASTER_ID":57352,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + zeinoxanthin <=> H(+) + H2O + lutein + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":5402,"KEGG":"R07532","RHEA_ID":54223,"DIRECTION":"BI","MASTER_ID":54220,"compounds":"1-hydroxy-all-trans-1,2-dihydro-neurosporene <=> all-trans-neurosporene + H2O","pmd":18.01}
{"X":5403,"KEGG":"R07534","RHEA_ID":59339,"DIRECTION":"BI","MASTER_ID":59336,"compounds":"1-hydroxy-all-trans-1,2-dihydro-neurosporene + A <=> AH2 + demethylspheroidene","pmd":2.016}
{"X":5404,"KEGG":"R07535","RHEA_ID":30906,"DIRECTION":"BI","MASTER_ID":30903,"compounds":"demethylspheroidene + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + spheroidene","pmd":14.016}
{"X":5405,"KEGG":"R07537","RHEA_ID":33030,"DIRECTION":"BI","MASTER_ID":33027,"compounds":"4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spheroidene <=> 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + spheroiden-2-one","pmd":13.979}
{"X":5406,"KEGG":"R07558","RHEA_ID":30326,"DIRECTION":"BI","MASTER_ID":30323,"compounds":"all-trans-beta-carotene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]","pmd":15.995}
{"X":5407,"KEGG":"R07559","RHEA_ID":30330,"DIRECTION":"BI","MASTER_ID":30327,"compounds":"beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> all-trans-zeaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]","pmd":15.995}
{"X":5408,"KEGG":"R07563","RHEA_ID":55667,"DIRECTION":"BI","MASTER_ID":55664,"compounds":"2 AH2 + echinenone + 2 O2 <=> 2 A + canthaxanthin + 3 H2O","pmd":13.979}
{"X":5409,"KEGG":"R07571","RHEA_ID":56771,"DIRECTION":"BI","MASTER_ID":56768,"compounds":"2 AH2 + all-trans-zeaxanthin + 2 O2 <=> 2 A + all-trans-adonixanthin + 3 H2O","pmd":13.979}
{"X":5410,"KEGG":"R07573","RHEA_ID":56775,"DIRECTION":"BI","MASTER_ID":56772,"compounds":"2 AH2 + all-trans-adonixanthin + 2 O2 <=> 2 A + all-trans-(3S,3'S)-astaxanthin + 3 H2O","pmd":13.979}
{"X":5411,"KEGG":"R07574","RHEA_ID":31546,"DIRECTION":"BI","MASTER_ID":31543,"compounds":"all-trans-zeaxanthin + 2 UDP-alpha-D-glucose <=> 2 H(+) + 2 UDP + zeaxanthin bis(beta-D-glucoside)","pmd":164.426}
{"X":5412,"KEGG":"R07574","RHEA_ID":31546,"DIRECTION":"BI","MASTER_ID":31543,"compounds":"all-trans-zeaxanthin + 2 UDP-alpha-D-glucose <=> 2 H(+) + 2 UDP + zeaxanthin bis(beta-D-glucoside)","pmd":162.053}
{"X":5413,"KEGG":"R07575","RHEA_ID":31034,"DIRECTION":"BI","MASTER_ID":31031,"compounds":"2-cis-(+)-abscisate + UDP-alpha-D-glucose <=> beta-D-glucopyranosyl cis-(+)-abscisate + UDP","pmd":139.866}
{"X":5414,"KEGG":"R07582","RHEA_ID":16540,"DIRECTION":"BI","MASTER_ID":16537,"compounds":"(9S,10S)-10-hydroxy-9-(phosphooxy)octadecanoate + H2O <=> (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate","pmd":79.966}
{"X":5415,"KEGG":"R07583","RHEA_ID":13004,"DIRECTION":"BI","MASTER_ID":13001,"compounds":"1D-myo-inositol hexakisphosphate + H2O <=> 1L-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate","pmd":79.966}
{"X":5416,"KEGG":"R07597","RHEA_ID":11967,"DIRECTION":"BI","MASTER_ID":11964,"metacyc":"RXN-8650","compounds":"5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O <=> 5alpha-cholestane-3beta,5,6beta-triol","pmd":18.01}
{"X":5417,"KEGG":"R07598","RHEA_ID":22551,"DIRECTION":"BI","MASTER_ID":22548,"compounds":"H2O + L-lysine + O2 <=> (S)-2-amino-6-oxohexanoate + H2O2 + NH4(+)","pmd":1.032}
{"X":5418,"KEGG":"R07605","RHEA_ID":13412,"DIRECTION":"BI","MASTER_ID":13409,"compounds":"7-aminomethyl-7-carbaguanine + 2 NADP(+) <=> 7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH","pmd":569.034}
{"X":5419,"KEGG":"R07605","RHEA_ID":13412,"DIRECTION":"BI","MASTER_ID":13409,"compounds":"7-aminomethyl-7-carbaguanine + 2 NADP(+) <=> 7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH","pmd":4.031}
{"X":5420,"KEGG":"R07606","RHEA_ID":19996,"DIRECTION":"BI","MASTER_ID":19993,"compounds":"[thioredoxin]-disulfide + H2O + L-methionine <=> [thioredoxin]-dithiol + L-methionine (S)-S-oxide","pmd":15.995}
{"X":5421,"KEGG":"R07607","RHEA_ID":24167,"DIRECTION":"BI","MASTER_ID":24164,"ecocyc":"1.8.4.12-RXN","metacyc":"1.8.4.12-RXN","compounds":"[thioredoxin]-disulfide + H2O + L-methionyl-[protein] <=> [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]"}
{"X":5422,"KEGG":"R07608","RHEA_ID":21263,"DIRECTION":"BI","MASTER_ID":21260,"compounds":"[thioredoxin]-disulfide + H2O + L-methionine <=> [thioredoxin]-dithiol + L-methionine (R)-S-oxide","pmd":15.995}
{"X":5423,"KEGG":"R07613","RHEA_ID":23991,"DIRECTION":"BI","MASTER_ID":23988,"metacyc":"RXN-7737","compounds":"(2S,6S)-2,6-diaminoheptanedioate + 2-oxoglutarate <=> (S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O + L-glutamate","pmd":19.042}
{"X":5424,"KEGG":"R07613","RHEA_ID":23991,"DIRECTION":"BI","MASTER_ID":23988,"metacyc":"RXN-7737","compounds":"(2S,6S)-2,6-diaminoheptanedioate + 2-oxoglutarate <=> (S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O + L-glutamate","pmd":1.032}
{"X":5425,"KEGG":"R07618","RHEA_ID":15048,"DIRECTION":"BI","MASTER_ID":15045,"compounds":"(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) <=> (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH"}
{"X":5426,"KEGG":"R07621","RHEA_ID":56259,"DIRECTION":"BI","MASTER_ID":56256,"compounds":"3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-threonyl-[protein] + UDP"}
{"X":5427,"KEGG":"R07621","RHEA_ID":56255,"DIRECTION":"BI","MASTER_ID":56252,"compounds":"3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-seryl-[protein] + UDP"}
{"X":5428,"KEGG":"R07626","RHEA_ID":14888,"DIRECTION":"BI","MASTER_ID":14885,"compounds":"H2O + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] <=> ADP-D-ribose + L-arginyl-[protein]"}
{"X":5429,"KEGG":"R07626","RHEA_ID":47323,"DIRECTION":"BI","MASTER_ID":47320,"compounds":"(S)-3-amino-3-phenylpropanoate + 2-oxoglutarate <=> 3-oxo-3-phenylpropanoate + L-glutamate"}
{"X":5430,"KEGG":"R07627","RHEA_ID":23903,"DIRECTION":"BI","MASTER_ID":23900,"compounds":"cis-stilbene oxide + H2O <=> (1R,2R)-hydrobenzoin","pmd":18.011}
{"X":5431,"KEGG":"R07629","RHEA_ID":17364,"DIRECTION":"BI","MASTER_ID":17361,"compounds":"3-oxo-3-ureidopropanoate + H2O <=> H(+) + malonate + urea","pmd":42.022}
{"X":5432,"KEGG":"R07630","RHEA_ID":18328,"DIRECTION":"BI","MASTER_ID":18325,"compounds":"(2E,6E)-farnesyl diphosphate <=> (+)-amorpha-4,11-diene + diphosphate","pmd":177.943}
{"X":5433,"KEGG":"R07631","RHEA_ID":24119,"DIRECTION":"BI","MASTER_ID":24116,"compounds":"(2E)-geranyl diphosphate + H2O <=> (S)-linalool + diphosphate","pmd":159.933}
{"X":5434,"KEGG":"R07632","RHEA_ID":15812,"DIRECTION":"BI","MASTER_ID":15809,"compounds":"(2E)-geranyl diphosphate + H2O <=> (R)-linalool + diphosphate","pmd":159.933}
{"X":5435,"KEGG":"R07633","RHEA_ID":21431,"DIRECTION":"BI","MASTER_ID":21428,"compounds":"(R)-3-sulfolactate <=> H(+) + pyruvate + sulfite"}
{"X":5436,"KEGG":"R07634","RHEA_ID":13444,"DIRECTION":"BI","MASTER_ID":13441,"compounds":"H2O + L-cysteate <=> H(+) + NH4(+) + pyruvate + sulfite"}
{"X":5437,"KEGG":"R07635","RHEA_ID":14336,"DIRECTION":"BI","MASTER_ID":14333,"metacyc":"3.1.4.47-RXN","compounds":"a 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol <=> 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol"}
{"X":5438,"KEGG":"R07636","RHEA_ID":13732,"DIRECTION":"BI","MASTER_ID":13729,"metacyc":"RXN-11695","compounds":"FAD <=> AMP + H(+) + riboflavin cyclic-4',5'-phosphate","pmd":347.063}
{"X":5439,"KEGG":"R07638","RHEA_ID":20072,"DIRECTION":"BI","MASTER_ID":20069,"compounds":"(Z)-phenylacetaldehyde oxime <=> H2O + phenylacetonitrile","pmd":18.011}
{"X":5440,"KEGG":"R07639","RHEA_ID":23571,"DIRECTION":"BI","MASTER_ID":23568,"ecocyc":"5.3.3.14-RXN","metacyc":"5.3.3.14-RXN","compounds":"(2E)-decenoyl-[ACP] <=> (3Z)-decenoyl-[ACP]"}
{"X":5441,"KEGG":"R07641","RHEA_ID":18032,"DIRECTION":"BI","MASTER_ID":18029,"compounds":"2 ATP + hydrogencarbonate + NH4(+) <=> 2 ADP + carbamoyl phosphate + 2 H(+) + phosphate","pmd":79.966}
{"X":5442,"KEGG":"R07644","RHEA_ID":30574,"DIRECTION":"BI","MASTER_ID":30571,"compounds":"3 2,3-dihydroxybenzoate + 6 ATP + 3 L-serine <=> 6 AMP + 6 diphosphate + enterobactin + 4 H(+)","pmd":242.021}
{"X":5443,"KEGG":"R07644","RHEA_ID":30574,"DIRECTION":"BI","MASTER_ID":30571,"compounds":"3 2,3-dihydroxybenzoate + 6 ATP + 3 L-serine <=> 6 AMP + 6 diphosphate + enterobactin + 4 H(+)","pmd":159.933}
{"X":5444,"KEGG":"R07644","RHEA_ID":30574,"DIRECTION":"BI","MASTER_ID":30571,"compounds":"3 2,3-dihydroxybenzoate + 6 ATP + 3 L-serine <=> 6 AMP + 6 diphosphate + enterobactin + 4 H(+)","pmd":193.037}
{"X":5445,"KEGG":"R07647","RHEA_ID":22439,"DIRECTION":"BI","MASTER_ID":22436,"compounds":"(2E,6E)-farnesyl diphosphate + H2O <=> (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate","pmd":159.933}
{"X":5446,"KEGG":"R07648","RHEA_ID":12019,"DIRECTION":"BI","MASTER_ID":12016,"compounds":"(2E,6E)-farnesyl diphosphate <=> (-)-germacrene D + diphosphate","pmd":177.943}
{"X":5447,"KEGG":"R07649","RHEA_ID":12519,"DIRECTION":"BI","MASTER_ID":12516,"compounds":"(2E,6E)-farnesyl diphosphate <=> (+)-(R)-germacrene A + diphosphate","pmd":177.943}
{"X":5448,"KEGG":"R07650","RHEA_ID":15692,"DIRECTION":"BI","MASTER_ID":15689,"compounds":"H(+) + L-2,4-diaminobutanoate <=> CO2 + propane-1,3-diamine"}
{"X":5449,"KEGG":"R07651","RHEA_ID":20664,"DIRECTION":"BI","MASTER_ID":20661,"compounds":"D-alanyl-D-alanine + H2O <=> 2 D-alanine"}
{"X":5450,"KEGG":"R07652","RHEA_ID":31550,"DIRECTION":"BI","MASTER_ID":31547,"metacyc":"RXN-12321","compounds":"2 (2E,6E)-farnesyl diphosphate <=> 15-cis-4,4'-diapophytoene + 2 diphosphate","pmd":26.245}
{"X":5451,"KEGG":"R07653","RHEA_ID":42803,"DIRECTION":"BI","MASTER_ID":42800,"metacyc":"RXN-15614","compounds":"15-cis-4,4'-diapophytoene + 3 FAD + 3 H(+) <=> all-trans-4,4'-diaponeurosporene + 3 FADH2","pmd":6.047}
{"X":5452,"KEGG":"R07653","RHEA_ID":42803,"DIRECTION":"BI","MASTER_ID":42800,"metacyc":"RXN-15614","compounds":"15-cis-4,4'-diapophytoene + 3 FAD + 3 H(+) <=> all-trans-4,4'-diaponeurosporene + 3 FADH2","pmd":2.016}
{"X":5453,"KEGG":"R07657","RHEA_ID":14752,"DIRECTION":"BI","MASTER_ID":14749,"metacyc":"1.13.11.38-RXN","compounds":"1-hydroxy-2-naphthoate + O2 <=> (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H(+)","pmd":31.99}
{"X":5454,"KEGG":"R07658","RHEA_ID":24705,"DIRECTION":"BI","MASTER_ID":24702,"compounds":"NAD(+) + UDP-alpha-D-glucuronate <=> CO2 + NADH + UDP-beta-L-threo-pentopyranos-4-ulose","pmd":130.088}
{"X":5455,"KEGG":"R07658","RHEA_ID":24705,"DIRECTION":"BI","MASTER_ID":24702,"compounds":"NAD(+) + UDP-alpha-D-glucuronate <=> CO2 + NADH + UDP-beta-L-threo-pentopyranos-4-ulose","pmd":46.005}
{"X":5456,"KEGG":"R07659","RHEA_ID":24713,"DIRECTION":"BI","MASTER_ID":24710,"ecocyc":"RXN0-1863","metacyc":"RXN0-1863","compounds":"2-oxoglutarate + UDP-4-amino-4-deoxy-beta-L-arabinose <=> L-glutamate + UDP-beta-L-threo-pentopyranos-4-ulose","pmd":1.032}
{"X":5457,"KEGG":"R07660","RHEA_ID":24709,"DIRECTION":"BI","MASTER_ID":24706,"compounds":"(6S)-10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinose <=> (6S)-5,6,7,8-tetrahydrofolate + H(+) + UDP-4-deoxy-4-formamido-beta-L-arabinose","pmd":27.995}
{"X":5458,"KEGG":"R07661","RHEA_ID":27725,"DIRECTION":"BI","MASTER_ID":27722,"compounds":"di-trans,octa-cis-undecaprenyl phosphate + UDP-4-deoxy-4-formamido-beta-L-arabinose <=> 4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + UDP","pmd":442.663}
{"X":5459,"KEGG":"R07661","RHEA_ID":27725,"DIRECTION":"BI","MASTER_ID":27722,"compounds":"di-trans,octa-cis-undecaprenyl phosphate + UDP-4-deoxy-4-formamido-beta-L-arabinose <=> 4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + UDP","pmd":159.053}
{"X":5460,"KEGG":"R07662","RHEA_ID":27737,"DIRECTION":"BI","MASTER_ID":27734,"compounds":"4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + H2O <=> 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + formate"}
{"X":5461,"KEGG":"R07671","RHEA_ID":42439,"DIRECTION":"BI","MASTER_ID":42436,"compounds":"L-ascorbate(out) + N(pros)-phospho-L-histidyl-[protein] <=> L-ascorbate 6-phosphate(in) + L-histidyl-[protein]","pmd":79.966}
{"X":5462,"KEGG":"R07674","RHEA_ID":26352,"DIRECTION":"BI","MASTER_ID":26349,"compounds":"beta-L-galactose 1-phosphate + H2O <=> L-galactose + phosphate","pmd":79.966}
{"X":5463,"KEGG":"R07675","RHEA_ID":31562,"DIRECTION":"BI","MASTER_ID":31559,"compounds":"L-galactose + NAD(+) <=> H(+) + L-galactono-1,4-lactone + NADH","pmd":486.069}
{"X":5464,"KEGG":"R07675","RHEA_ID":31562,"DIRECTION":"BI","MASTER_ID":31559,"compounds":"L-galactose + NAD(+) <=> H(+) + L-galactono-1,4-lactone + NADH","pmd":2.016}
{"X":5465,"KEGG":"R07676","RHEA_ID":26348,"DIRECTION":"BI","MASTER_ID":26345,"metacyc":"RXN-11151","compounds":"L-galactonate + NADP(+) <=> aldehydo-D-galacturonate + H(+) + NADPH","pmd":2.016}
{"X":5466,"KEGG":"R07676","RHEA_ID":26348,"DIRECTION":"BI","MASTER_ID":26345,"metacyc":"RXN-11151","compounds":"L-galactonate + NADP(+) <=> aldehydo-D-galacturonate + H(+) + NADPH","pmd":550.041}
{"X":5467,"KEGG":"R07677","RHEA_ID":28806,"DIRECTION":"BI","MASTER_ID":28803,"compounds":"H2O + L-ascorbate 6-phosphate <=> 3-dehydro-L-gulonate 6-phosphate","pmd":18.011}
{"X":5468,"KEGG":"R07678","RHEA_ID":27701,"DIRECTION":"BI","MASTER_ID":27698,"compounds":"GDP-beta-L-galactose + phosphate <=> beta-L-galactose 1-phosphate + GDP + H(+)","pmd":162.053}
{"X":5469,"KEGG":"R07679","RHEA_ID":15852,"DIRECTION":"BI","MASTER_ID":15849,"compounds":"2 [Fe(III)cytochrome c] + L-ascorbate <=> 2 [Fe(II)cytochrome c] + 2 H(+) + L-dehydroascorbate","pmd":2.016}
{"X":5470,"KEGG":"R07679","RHEA_ID":14760,"DIRECTION":"BI","MASTER_ID":14757,"compounds":"2 [Fe(III)cytochrome c] + L-galactono-1,4-lactone <=> 2 [Fe(II)cytochrome c] + 3 H(+) + L-ascorbate","pmd":2.016}
{"X":5471,"KEGG":"R07706","RHEA_ID":46511,"DIRECTION":"BI","MASTER_ID":46508,"compounds":"NADH + nitrobenzene + O2 <=> catechol + NAD(+) + nitrite","pmd":555.088}
{"X":5472,"KEGG":"R07706","RHEA_ID":46511,"DIRECTION":"BI","MASTER_ID":46508,"compounds":"NADH + nitrobenzene + O2 <=> catechol + NAD(+) + nitrite","pmd":12.995}
{"X":5473,"KEGG":"R07709","RHEA_ID":35310,"DIRECTION":"BI","MASTER_ID":35307,"compounds":"H(+) + NADH + O2 + salicylate <=> 2,5-dihydroxybenzoate + H2O + NAD(+)","pmd":15.995}
{"X":5474,"KEGG":"R07709","RHEA_ID":35310,"DIRECTION":"BI","MASTER_ID":35307,"compounds":"H(+) + NADH + O2 + salicylate <=> 2,5-dihydroxybenzoate + H2O + NAD(+)","pmd":511.098}
{"X":5475,"KEGG":"R07713","RHEA_ID":16456,"DIRECTION":"BI","MASTER_ID":16453,"metacyc":"4.1.2.34-RXN","compounds":"(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H2O <=> 2-formylbenzoate + pyruvate","pmd":70.006}
{"X":5476,"KEGG":"R07720","RHEA_ID":56051,"DIRECTION":"BI","MASTER_ID":56048,"compounds":"daidzein + UDP-alpha-D-glucose <=> daidzein 7-O-beta-D-glucoside + UDP","pmd":149.944}
{"X":5477,"KEGG":"R07722","RHEA_ID":31374,"DIRECTION":"BI","MASTER_ID":31371,"compounds":"(2R,3S)-2,4',7-trihydroxyisoflavanone + S-adenosyl-L-methionine <=> (2R,3S)-2,7-dihydroxy-4'-methoxyisoflavanone + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5478,"KEGG":"R07729","RHEA_ID":17500,"DIRECTION":"BI","MASTER_ID":17497,"compounds":"formononetin + UDP-alpha-D-glucose <=> ononin + UDP","pmd":135.929}
{"X":5479,"KEGG":"R07737","RHEA_ID":35406,"DIRECTION":"BI","MASTER_ID":35403,"compounds":"(3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol + NADP(+) <=> (3R)-vestitone + H(+) + NADPH","pmd":456.991}
{"X":5480,"KEGG":"R07737","RHEA_ID":35406,"DIRECTION":"BI","MASTER_ID":35403,"compounds":"(3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol + NADP(+) <=> (3R)-vestitone + H(+) + NADPH","pmd":2.016}
{"X":5481,"KEGG":"R07738","RHEA_ID":35814,"DIRECTION":"BI","MASTER_ID":35811,"compounds":"(3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol <=> (-)-medicarpin + H2O","pmd":18.011}
{"X":5482,"KEGG":"R07745","RHEA_ID":28241,"DIRECTION":"BI","MASTER_ID":28238,"compounds":"calycosin + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + pseudobaptigenin","pmd":2.016}
{"X":5483,"KEGG":"R07750","RHEA_ID":35474,"DIRECTION":"BI","MASTER_ID":35471,"compounds":"(+)-6a-hydroxymaackiain + S-adenosyl-L-methionine <=> (+)-pisatin + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5484,"KEGG":"R07766","RHEA_ID":17668,"DIRECTION":"BI","MASTER_ID":17665,"compounds":"L-lysyl-[protein] + octanoyl-[ACP] <=> H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]"}
{"X":5485,"KEGG":"R07767","RHEA_ID":16588,"DIRECTION":"BI","MASTER_ID":16585,"compounds":"[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine <=> (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]","pmd":147.035}
{"X":5486,"KEGG":"R07770","RHEA_ID":12916,"DIRECTION":"BI","MASTER_ID":12913,"compounds":"(R)-lipoate + ATP + H(+) <=> (R)-lipoyl-5'-AMP + diphosphate","pmd":329.053}
{"X":5487,"KEGG":"R07770","RHEA_ID":12916,"DIRECTION":"BI","MASTER_ID":12913,"compounds":"(R)-lipoate + ATP + H(+) <=> (R)-lipoyl-5'-AMP + diphosphate","pmd":28.1}
{"X":5488,"KEGG":"R07771","RHEA_ID":20476,"DIRECTION":"BI","MASTER_ID":20473,"compounds":"(R)-lipoyl-5'-AMP + [lipoyl-carrier protein]-L-lysine <=> [lipoyl-carrier protein]-(R)-N(6)-lipoyl-L-lysine + AMP + 2 H(+)","pmd":188.033}
{"X":5489,"KEGG":"R07772","RHEA_ID":26284,"DIRECTION":"BI","MASTER_ID":26281,"compounds":"Co-precorrin-5A + H2O <=> acetaldehyde + Co-precorrin-5B + H(+)","pmd":26.016}
{"X":5490,"KEGG":"R07773","RHEA_ID":26288,"DIRECTION":"BI","MASTER_ID":26285,"compounds":"Co-precorrin-5B + S-adenosyl-L-methionine <=> Co-precorrin-6A + S-adenosyl-L-homocysteine","pmd":15.024}
{"X":5491,"KEGG":"R07773","RHEA_ID":26288,"DIRECTION":"BI","MASTER_ID":26285,"compounds":"Co-precorrin-5B + S-adenosyl-L-methionine <=> Co-precorrin-6A + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5492,"KEGG":"R07775","RHEA_ID":34594,"DIRECTION":"BI","MASTER_ID":34591,"compounds":"Co-precorrin-7 + S-adenosyl-L-methionine <=> Co-precorrin-8X + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5493,"KEGG":"R07777","RHEA_ID":31726,"DIRECTION":"BI","MASTER_ID":31723,"compounds":"liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase] <=> (2R,3S)-2,4',7-trihydroxyisoflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":5494,"KEGG":"R07778","RHEA_ID":35490,"DIRECTION":"BI","MASTER_ID":35487,"compounds":"(S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-2,3-dihydrogenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":5495,"KEGG":"R07791","RHEA_ID":27328,"DIRECTION":"BI","MASTER_ID":27325,"compounds":"(22S,24R)-22-hydroxy-5alpha-ergostan-3-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-dehydro-6-deoxoteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":5496,"KEGG":"R07792","RHEA_ID":27324,"DIRECTION":"BI","MASTER_ID":27321,"compounds":"3-epi-6-deoxocathasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6-deoxotyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":5497,"KEGG":"R07796","RHEA_ID":15604,"DIRECTION":"BI","MASTER_ID":15601,"metacyc":"2.8.3.17-RXN","compounds":"(E)-cinnamoyl-CoA + (R)-3-phenyllactate <=> (R)-3-phenyllactoyl-CoA + trans-cinnamate","pmd":18.011}
{"X":5498,"KEGG":"R07796","RHEA_ID":15604,"DIRECTION":"BI","MASTER_ID":15601,"metacyc":"2.8.3.17-RXN","compounds":"(E)-cinnamoyl-CoA + (R)-3-phenyllactate <=> (R)-3-phenyllactoyl-CoA + trans-cinnamate","pmd":18.01}
{"X":5499,"KEGG":"R07797","RHEA_ID":17000,"DIRECTION":"BI","MASTER_ID":16997,"compounds":"3'-phosphoadenylyl sulfate + 5alpha-cholane-3alpha,7alpha,12alpha,24-tetrol <=> 3alpha,7alpha,12alpha-trihydroxy-5alpha-cholan-24-yl sulfate + adenosine 3',5'-bisphosphate + H(+)","pmd":32.721}
{"X":5500,"KEGG":"R07798","RHEA_ID":15480,"DIRECTION":"BI","MASTER_ID":15477,"compounds":"3'-phosphoadenylyl sulfate + 5beta-scymnol <=> 5beta-scymnol sulfate + adenosine 3',5'-bisphosphate + H(+)","pmd":41.316}
{"X":5501,"KEGG":"R07830","RHEA_ID":25995,"DIRECTION":"BI","MASTER_ID":25992,"compounds":"(2E,6E)-farnesyl diphosphate <=> (+)-epi-isozizaene + diphosphate","pmd":177.943}
{"X":5502,"KEGG":"R07839","RHEA_ID":28934,"DIRECTION":"BI","MASTER_ID":28931,"ecocyc":"RXN-9983","metacyc":"RXN-9983","compounds":"(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate <=> 4-carboxy-2-hydroxy-cis,cis-muconate","pmd":0}
{"X":5503,"KEGG":"R07840","RHEA_ID":53131,"DIRECTION":"BI","MASTER_ID":53128,"compounds":"delta-carotene <=> epsilon-carotene","pmd":0}
{"X":5504,"KEGG":"R07850","RHEA_ID":30402,"DIRECTION":"BI","MASTER_ID":30399,"compounds":"alpha-carotene + O2 + reduced [NADPH--hemoprotein reductase] <=> alpha-cryptoxanthin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":5505,"KEGG":"R07863","RHEA_ID":25077,"DIRECTION":"BI","MASTER_ID":25074,"compounds":"(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate <=> (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate + H2O","pmd":18.011}
{"X":5506,"KEGG":"R07869","RHEA_ID":34498,"DIRECTION":"BI","MASTER_ID":34495,"compounds":"(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate","pmd":31.99}
{"X":5507,"KEGG":"R07913","RHEA_ID":26501,"DIRECTION":"BI","MASTER_ID":26498,"compounds":"delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + UDP-alpha-D-glucose <=> delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP","pmd":147.102}
{"X":5508,"KEGG":"R07913","RHEA_ID":26501,"DIRECTION":"BI","MASTER_ID":26498,"compounds":"delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + UDP-alpha-D-glucose <=> delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP","pmd":147.101}
{"X":5509,"KEGG":"R07914","RHEA_ID":26505,"DIRECTION":"BI","MASTER_ID":26502,"compounds":"delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP-alpha-D-glucose <=> 2 H(+) + ternatin C5 + UDP","pmd":162.053}
{"X":5510,"KEGG":"R07916","RHEA_ID":32454,"DIRECTION":"BI","MASTER_ID":32451,"compounds":"2 all-trans-geranylgeranyl diphosphate <=> all-trans-phytoene + 2 diphosphate","pmd":94.307}
{"X":5511,"KEGG":"R07917","RHEA_ID":15028,"DIRECTION":"BI","MASTER_ID":15025,"compounds":"S-adenosyl-L-methionine + xanthosine <=> 7-methylxanthosine + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5512,"KEGG":"R07917","RHEA_ID":15028,"DIRECTION":"BI","MASTER_ID":15025,"compounds":"S-adenosyl-L-methionine + xanthosine <=> 7-methylxanthosine + S-adenosyl-L-homocysteine","pmd":15.024}
{"X":5513,"KEGG":"R07918","RHEA_ID":10883,"DIRECTION":"BI","MASTER_ID":10880,"compounds":"7-methylxanthosine + H2O <=> 7-methylxanthine + D-ribose + H(+)","pmd":133.05}
{"X":5514,"KEGG":"R07919","RHEA_ID":24607,"DIRECTION":"BI","MASTER_ID":24604,"compounds":"7-methylxanthine + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + theobromine","pmd":14.016}
{"X":5515,"KEGG":"R07920","RHEA_ID":20947,"DIRECTION":"BI","MASTER_ID":20944,"compounds":"S-adenosyl-L-methionine + theobromine <=> caffeine + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5516,"KEGG":"R07921","RHEA_ID":10283,"DIRECTION":"BI","MASTER_ID":10280,"compounds":"1,7-dimethylxanthine + S-adenosyl-L-methionine <=> caffeine + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5517,"KEGG":"R07933","RHEA_ID":47147,"DIRECTION":"BI","MASTER_ID":47144,"compounds":"(9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":5518,"KEGG":"R07946","RHEA_ID":42355,"DIRECTION":"BI","MASTER_ID":42352,"compounds":"(R)-nicotine + A + H2O <=> (R)-6-hydroxynicotine + AH2","pmd":15.995}
{"X":5519,"KEGG":"R07955","RHEA_ID":36270,"DIRECTION":"BI","MASTER_ID":36267,"compounds":"caffeine + H(+) + NADH + O2 <=> formaldehyde + H2O + NAD(+) + theobromine","pmd":485.06}
{"X":5520,"KEGG":"R07955","RHEA_ID":36270,"DIRECTION":"BI","MASTER_ID":36267,"compounds":"caffeine + H(+) + NADH + O2 <=> formaldehyde + H2O + NAD(+) + theobromine","pmd":14.016}
{"X":5521,"KEGG":"R07956","RHEA_ID":36274,"DIRECTION":"BI","MASTER_ID":36271,"compounds":"caffeine + H(+) + NADPH + O2 <=> formaldehyde + H2O + NADP(+) + theobromine","pmd":14.016}
{"X":5522,"KEGG":"R07956","RHEA_ID":36274,"DIRECTION":"BI","MASTER_ID":36271,"compounds":"caffeine + H(+) + NADPH + O2 <=> formaldehyde + H2O + NADP(+) + theobromine","pmd":565.026}
{"X":5523,"KEGG":"R07957","RHEA_ID":30318,"DIRECTION":"BI","MASTER_ID":30315,"compounds":"1,7-dimethylxanthine + H(+) + NADH + O2 <=> 7-methylxanthine + formaldehyde + H2O + NAD(+)","pmd":499.076}
{"X":5524,"KEGG":"R07957","RHEA_ID":30318,"DIRECTION":"BI","MASTER_ID":30315,"compounds":"1,7-dimethylxanthine + H(+) + NADH + O2 <=> 7-methylxanthine + formaldehyde + H2O + NAD(+)","pmd":14.016}
{"X":5525,"KEGG":"R07958","RHEA_ID":36286,"DIRECTION":"BI","MASTER_ID":36283,"compounds":"1,7-dimethylxanthine + H(+) + NADPH + O2 <=> 7-methylxanthine + formaldehyde + H2O + NADP(+)","pmd":579.042}
{"X":5526,"KEGG":"R07958","RHEA_ID":36286,"DIRECTION":"BI","MASTER_ID":36283,"compounds":"1,7-dimethylxanthine + H(+) + NADPH + O2 <=> 7-methylxanthine + formaldehyde + H2O + NADP(+)","pmd":14.016}
{"X":5527,"KEGG":"R07961","RHEA_ID":30322,"DIRECTION":"BI","MASTER_ID":30319,"compounds":"H(+) + NADH + O2 + theobromine <=> 7-methylxanthine + formaldehyde + H2O + NAD(+)","pmd":14.016}
{"X":5528,"KEGG":"R07961","RHEA_ID":30322,"DIRECTION":"BI","MASTER_ID":30319,"compounds":"H(+) + NADH + O2 + theobromine <=> 7-methylxanthine + formaldehyde + H2O + NAD(+)","pmd":499.076}
{"X":5529,"KEGG":"R07962","RHEA_ID":36290,"DIRECTION":"BI","MASTER_ID":36287,"compounds":"H(+) + NADPH + O2 + theobromine <=> 7-methylxanthine + formaldehyde + H2O + NADP(+)","pmd":579.042}
{"X":5530,"KEGG":"R07962","RHEA_ID":36290,"DIRECTION":"BI","MASTER_ID":36287,"compounds":"H(+) + NADPH + O2 + theobromine <=> 7-methylxanthine + formaldehyde + H2O + NADP(+)","pmd":14.016}
{"X":5531,"KEGG":"R07965","RHEA_ID":30314,"DIRECTION":"BI","MASTER_ID":30311,"compounds":"7-methylxanthine + H(+) + NADH + O2 <=> formaldehyde + H2O + NAD(+) + xanthine","pmd":513.091}
{"X":5532,"KEGG":"R07965","RHEA_ID":30314,"DIRECTION":"BI","MASTER_ID":30311,"compounds":"7-methylxanthine + H(+) + NADH + O2 <=> formaldehyde + H2O + NAD(+) + xanthine","pmd":14.016}
{"X":5533,"KEGG":"R07966","RHEA_ID":30310,"DIRECTION":"BI","MASTER_ID":30307,"compounds":"7-methylxanthine + H(+) + NADPH + O2 <=> formaldehyde + H2O + NADP(+) + xanthine","pmd":593.058}
{"X":5534,"KEGG":"R07966","RHEA_ID":30310,"DIRECTION":"BI","MASTER_ID":30307,"compounds":"7-methylxanthine + H(+) + NADPH + O2 <=> formaldehyde + H2O + NADP(+) + xanthine","pmd":14.016}
{"X":5535,"KEGG":"R07967","RHEA_ID":30450,"DIRECTION":"BI","MASTER_ID":30447,"compounds":"3-methylxanthine + H(+) + NADH + O2 <=> formaldehyde + H2O + NAD(+) + xanthine","pmd":14.016}
{"X":5536,"KEGG":"R07967","RHEA_ID":30450,"DIRECTION":"BI","MASTER_ID":30447,"compounds":"3-methylxanthine + H(+) + NADH + O2 <=> formaldehyde + H2O + NAD(+) + xanthine","pmd":513.091}
{"X":5537,"KEGG":"R07968","RHEA_ID":36294,"DIRECTION":"BI","MASTER_ID":36291,"compounds":"3-methylxanthine + H(+) + NADPH + O2 <=> formaldehyde + H2O + NADP(+) + xanthine","pmd":593.058}
{"X":5538,"KEGG":"R07968","RHEA_ID":36294,"DIRECTION":"BI","MASTER_ID":36291,"compounds":"3-methylxanthine + H(+) + NADPH + O2 <=> formaldehyde + H2O + NADP(+) + xanthine","pmd":14.016}
{"X":5539,"KEGG":"R07973","RHEA_ID":36282,"DIRECTION":"BI","MASTER_ID":36279,"compounds":"H(+) + NADH + O2 + theophylline <=> 3-methylxanthine + formaldehyde + H2O + NAD(+)","pmd":499.076}
{"X":5540,"KEGG":"R07973","RHEA_ID":36282,"DIRECTION":"BI","MASTER_ID":36279,"compounds":"H(+) + NADH + O2 + theophylline <=> 3-methylxanthine + formaldehyde + H2O + NAD(+)","pmd":14.016}
{"X":5541,"KEGG":"R07974","RHEA_ID":36278,"DIRECTION":"BI","MASTER_ID":36275,"compounds":"H(+) + NADPH + O2 + theophylline <=> 3-methylxanthine + formaldehyde + H2O + NADP(+)","pmd":579.042}
{"X":5542,"KEGG":"R07974","RHEA_ID":36278,"DIRECTION":"BI","MASTER_ID":36275,"compounds":"H(+) + NADPH + O2 + theophylline <=> 3-methylxanthine + formaldehyde + H2O + NADP(+)","pmd":14.016}
{"X":5543,"KEGG":"R07980","RHEA_ID":47151,"DIRECTION":"BI","MASTER_ID":47148,"compounds":"a ubiquinone + caffeine + H2O <=> 1,3,7-trimethylurate + a ubiquinol","pmd":15.995}
{"X":5544,"KEGG":"R07984","RHEA_ID":17212,"DIRECTION":"BI","MASTER_ID":17209,"compounds":"1,4,5,6-tetrahydro-6-oxonicotinate + 2 H2O <=> 2-formylglutarate + NH4(+)","pmd":18.995}
{"X":5545,"KEGG":"R07985","RHEA_ID":15508,"DIRECTION":"BI","MASTER_ID":15505,"compounds":"2-(hydroxymethyl)glutarate + NAD(+) <=> 2-formylglutarate + H(+) + NADH","pmd":2.016}
{"X":5546,"KEGG":"R07985","RHEA_ID":15508,"DIRECTION":"BI","MASTER_ID":15505,"compounds":"2-(hydroxymethyl)glutarate + NAD(+) <=> 2-formylglutarate + H(+) + NADH","pmd":503.072}
{"X":5547,"KEGG":"R07986","RHEA_ID":27585,"DIRECTION":"BI","MASTER_ID":27582,"compounds":"2-(hydroxymethyl)glutarate <=> 2-methyleneglutarate + H2O","pmd":18.01}
{"X":5548,"KEGG":"R08004","RHEA_ID":51699,"DIRECTION":"BI","MASTER_ID":51696,"compounds":"desmethylxanthohumol + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + xanthohumol","pmd":14.016}
{"X":5549,"KEGG":"R08006","RHEA_ID":34294,"DIRECTION":"BI","MASTER_ID":34291,"compounds":"2',4,4',6'-tetrahydroxychalcone + UDP-alpha-D-glucose <=> 2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP","pmd":131.934}
{"X":5550,"KEGG":"R08007","RHEA_ID":34298,"DIRECTION":"BI","MASTER_ID":34295,"compounds":"2',3,4,4',6'-pentahydroxychalcone + UDP-alpha-D-glucose <=> 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP","pmd":115.939}
{"X":5551,"KEGG":"R08008","RHEA_ID":34206,"DIRECTION":"BI","MASTER_ID":34203,"compounds":"2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2 <=> aureusidin 6-O-beta-glucoside + H2O","pmd":13.979}
{"X":5552,"KEGG":"R08009","RHEA_ID":34202,"DIRECTION":"BI","MASTER_ID":34199,"compounds":"2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2 <=> bracteatin 6-O-beta-glucoside + H2O","pmd":13.979}
{"X":5553,"KEGG":"R08010","RHEA_ID":34198,"DIRECTION":"BI","MASTER_ID":34195,"compounds":"2 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + 2 H(+) + O2 <=> 2 aureusidin 6-O-beta-glucoside + 2 H2O","pmd":2.016}
{"X":5554,"KEGG":"R08012","RHEA_ID":60951,"DIRECTION":"BI","MASTER_ID":60948,"compounds":"(S)-eriodictyol + S-adenosyl-L-methionine <=> (S)-homoeriodictyol + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5555,"KEGG":"R08050","RHEA_ID":45743,"DIRECTION":"BI","MASTER_ID":45740,"compounds":"2-oxoglutarate + L-ectoine + O2 <=> 5-hydroxyectoine + CO2 + succinate","pmd":12.048}
{"X":5556,"KEGG":"R08050","RHEA_ID":45743,"DIRECTION":"BI","MASTER_ID":45740,"compounds":"2-oxoglutarate + L-ectoine + O2 <=> 5-hydroxyectoine + CO2 + succinate","pmd":15.995}
{"X":5557,"KEGG":"R08051","RHEA_ID":36334,"DIRECTION":"BI","MASTER_ID":36331,"compounds":"ATP + dimethylallyl diphosphate <=> diphosphate + N(6)-(dimethylallyl)adenosine 5'-triphosphate","pmd":329.053}
{"X":5558,"KEGG":"R08051","RHEA_ID":36334,"DIRECTION":"BI","MASTER_ID":36331,"compounds":"ATP + dimethylallyl diphosphate <=> diphosphate + N(6)-(dimethylallyl)adenosine 5'-triphosphate","pmd":68.063}
{"X":5559,"KEGG":"R08052","RHEA_ID":36330,"DIRECTION":"BI","MASTER_ID":36327,"compounds":"ADP + dimethylallyl diphosphate <=> diphosphate + N(6)-(dimethylallyl)adenosine 5'-diphosphate","pmd":68.063}
{"X":5560,"KEGG":"R08052","RHEA_ID":36330,"DIRECTION":"BI","MASTER_ID":36327,"compounds":"ADP + dimethylallyl diphosphate <=> diphosphate + N(6)-(dimethylallyl)adenosine 5'-diphosphate","pmd":249.086}
{"X":5561,"KEGG":"R08057","RHEA_ID":24901,"DIRECTION":"BI","MASTER_ID":24898,"compounds":"2 GTP <=> cyclic di-3',5'-guanylate + 2 diphosphate","pmd":167.104}
{"X":5562,"KEGG":"R08058","RHEA_ID":24681,"DIRECTION":"BI","MASTER_ID":24678,"compounds":"5,6,7,8-tetrahydromethanopterin + formaldehyde <=> 5,10-methylenetetrahydromethanopterin + H2O","pmd":12}
{"X":5563,"KEGG":"R08059","RHEA_ID":53387,"DIRECTION":"BI","MASTER_ID":53384,"metacyc":"RXN-2883","compounds":"5,10-methylenetetrahydromethanopterin + NAD(+) <=> 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADH","pmd":43.172}
{"X":5564,"KEGG":"R08059","RHEA_ID":24685,"DIRECTION":"BI","MASTER_ID":24682,"metacyc":"RXN-2883","compounds":"5,10-methylenetetrahydromethanopterin + NADP(+) <=> 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADPH","pmd":43.172}
{"X":5565,"KEGG":"R08060","RHEA_ID":24689,"DIRECTION":"BI","MASTER_ID":24686,"compounds":"H2O + N-formylmethanofuran <=> formate + methanofuran","pmd":27.995}
{"X":5566,"KEGG":"R08069","RHEA_ID":48563,"DIRECTION":"BI","MASTER_ID":48560,"compounds":"H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate <=> D-ribose 5-phosphate + N(6)-dimethylallyladenine","pmd":79.966}
{"X":5567,"KEGG":"R08070","RHEA_ID":48567,"DIRECTION":"BI","MASTER_ID":48564,"compounds":"9-ribosyl-trans-zeatin 5'-phosphate + H2O <=> D-ribose 5-phosphate + trans-zeatin","pmd":79.966}
{"X":5568,"KEGG":"R08090","RHEA_ID":23087,"DIRECTION":"BI","MASTER_ID":23084,"compounds":"3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA <=> 7-methyl-3-oxooct-6-enoyl-CoA + acetate","pmd":60.021}
{"X":5569,"KEGG":"R08124","RHEA_ID":28381,"DIRECTION":"BI","MASTER_ID":28378,"compounds":"ATP + N(6)-(D-fructosyl)-L-lysine <=> ADP + H(+) + N(6)-(6-phospho-D-fructosyl)-L-lysine","pmd":79.966}
{"X":5570,"KEGG":"R08125","RHEA_ID":28385,"DIRECTION":"BI","MASTER_ID":28382,"ecocyc":"RXN0-963","metacyc":"RXN0-963","compounds":"H2O + N(6)-(6-phospho-D-fructosyl)-L-lysine <=> D-glucose 6-phosphate + L-lysine","pmd":128.095}
{"X":5571,"KEGG":"R08146","RHEA_ID":24219,"DIRECTION":"BI","MASTER_ID":24216,"compounds":"(2E,6E)-farnesal + H2O + NAD(+) <=> (2E,6E)-farnesoate + 2 H(+) + NADH","pmd":427.939}
{"X":5572,"KEGG":"R08146","RHEA_ID":24219,"DIRECTION":"BI","MASTER_ID":24216,"compounds":"(2E,6E)-farnesal + H2O + NAD(+) <=> (2E,6E)-farnesoate + 2 H(+) + NADH","pmd":15.995}
{"X":5573,"KEGG":"R08147","RHEA_ID":43703,"DIRECTION":"BI","MASTER_ID":43700,"compounds":"(2E,6E)-farnesoate + S-adenosyl-L-methionine <=> methyl (2E,6E)-farnesoate + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5574,"KEGG":"R08148","RHEA_ID":43731,"DIRECTION":"BI","MASTER_ID":43728,"compounds":"methyl (2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + juvenile hormone III + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":5575,"KEGG":"R08149","RHEA_ID":46919,"DIRECTION":"BI","MASTER_ID":46916,"metacyc":"RXN-16609","compounds":"H2O + juvenile hormone I <=> H(+) + juvenile hormone I carboxylate + methanol","pmd":14.016}
{"X":5576,"KEGG":"R08149","RHEA_ID":46915,"DIRECTION":"BI","MASTER_ID":46912,"compounds":"H2O + juvenile hormone III <=> H(+) + juvenile hormone III carboxylate + methanol","pmd":14.016}
{"X":5577,"KEGG":"R08151","RHEA_ID":43723,"DIRECTION":"BI","MASTER_ID":43720,"compounds":"juvenile hormone III carboxylate + S-adenosyl-L-methionine <=> juvenile hormone III + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5578,"KEGG":"R08157","RHEA_ID":30134,"DIRECTION":"BI","MASTER_ID":30131,"compounds":"H2O + octanoyl-[ACP] <=> H(+) + holo-[ACP] + octanoate"}
{"X":5579,"KEGG":"R08158","RHEA_ID":30118,"DIRECTION":"BI","MASTER_ID":30115,"compounds":"decanoyl-[ACP] + H2O <=> decanoate + H(+) + holo-[ACP]"}
{"X":5580,"KEGG":"R08159","RHEA_ID":30126,"DIRECTION":"BI","MASTER_ID":30123,"compounds":"H2O + tetradecanoyl-[ACP] <=> H(+) + holo-[ACP] + tetradecanoate"}
{"X":5581,"KEGG":"R08160","RHEA_ID":33282,"DIRECTION":"BI","MASTER_ID":33279,"compounds":"L-tryptophan + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-(indol-3-yl)acetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]","pmd":30.011}
{"X":5582,"KEGG":"R08164","RHEA_ID":52155,"DIRECTION":"BI","MASTER_ID":52152,"compounds":"(E)-2-(1H-indol-3-yl)-1-thioacetohydroximate + UDP-alpha-D-glucose <=> indolylmethyl-desulfoglucosinolate + UDP","pmd":162.053}
{"X":5583,"KEGG":"R08165","RHEA_ID":25596,"DIRECTION":"BI","MASTER_ID":25593,"compounds":"2-oxoglutarate + H(+) + isochorismate <=> 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2","pmd":102.032}
{"X":5584,"KEGG":"R08165","RHEA_ID":25596,"DIRECTION":"BI","MASTER_ID":25593,"compounds":"2-oxoglutarate + H(+) + isochorismate <=> 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2","pmd":182.058}
{"X":5585,"KEGG":"R08166","RHEA_ID":25600,"DIRECTION":"BI","MASTER_ID":25597,"compounds":"5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate <=> (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate + pyruvate","pmd":88.016}
{"X":5586,"KEGG":"R08167","RHEA_ID":52739,"DIRECTION":"BI","MASTER_ID":52736,"compounds":"3'-phosphoadenylyl sulfate + indolylmethyl-desulfoglucosinolate <=> adenosine 3',5'-bisphosphate + glucobrassicin + H(+)","pmd":58.925}
{"X":5587,"KEGG":"R08171","RHEA_ID":33690,"DIRECTION":"BI","MASTER_ID":33687,"compounds":"3'-N-debenzoyltaxol + benzoyl-CoA <=> CoA + H(+) + taxol","pmd":17.81}
{"X":5588,"KEGG":"R08172","RHEA_ID":42491,"DIRECTION":"BI","MASTER_ID":42488,"compounds":"(3R)-3-amino-3-phenylpropanoyl-CoA + baccatin III <=> 3'-N-debenzoyl-2'-deoxytaxol + CoA","pmd":147.068}
{"X":5589,"KEGG":"R08173","RHEA_ID":42495,"DIRECTION":"BI","MASTER_ID":42492,"compounds":"3'-N-debenzoyl-2'-deoxytaxol + AH2 + O2 <=> 3'-N-debenzoyltaxol + A + H2O","pmd":15.995}
{"X":5590,"KEGG":"R08174","RHEA_ID":30142,"DIRECTION":"BI","MASTER_ID":30139,"compounds":"H2O + octadecanoyl-CoA <=> CoA + H(+) + octadecanoate"}
{"X":5591,"KEGG":"R08193","RHEA_ID":23807,"DIRECTION":"BI","MASTER_ID":23804,"metacyc":"PHOSACETYLGLUCOSAMINEMUT-RXN","compounds":"N-acetyl-alpha-D-glucosamine 1-phosphate <=> N-acetyl-D-glucosamine 6-phosphate","pmd":0}
{"X":5592,"KEGG":"R08195","RHEA_ID":15260,"DIRECTION":"BI","MASTER_ID":15257,"metacyc":"4.1.2.42-RXN","compounds":"D-threonine <=> acetaldehyde + glycine"}
{"X":5593,"KEGG":"R08196","RHEA_ID":20076,"DIRECTION":"BI","MASTER_ID":20073,"metacyc":"RXN-9702","compounds":"D-allothreonine <=> acetaldehyde + glycine"}
{"X":5594,"KEGG":"R08197","RHEA_ID":13836,"DIRECTION":"BI","MASTER_ID":13833,"metacyc":"RXN-8956","compounds":"L-arginine + pyruvate <=> 5-guanidino-2-oxopentanoate + L-alanine","pmd":1.032}
{"X":5595,"KEGG":"R08198","RHEA_ID":13452,"DIRECTION":"BI","MASTER_ID":13449,"ecocyc":"RXN-8645","compounds":"2-hydroxyglutarate + NAD(+) <=> 2-oxoglutarate + H(+) + NADH","pmd":518.095}
{"X":5596,"KEGG":"R08198","RHEA_ID":13452,"DIRECTION":"BI","MASTER_ID":13449,"ecocyc":"RXN-8645","compounds":"2-hydroxyglutarate + NAD(+) <=> 2-oxoglutarate + H(+) + NADH","pmd":2.016}
{"X":5597,"KEGG":"R08199","RHEA_ID":13372,"DIRECTION":"BI","MASTER_ID":13369,"compounds":"dimethylallyl diphosphate <=> diphosphate + isoprene"}
{"X":5598,"KEGG":"R08200","RHEA_ID":16676,"DIRECTION":"BI","MASTER_ID":16673,"metacyc":"3.11.1.3-RXN","compounds":"3-phosphonopyruvate + H2O <=> H(+) + phosphate + pyruvate"}
{"X":5599,"KEGG":"R08201","RHEA_ID":20428,"DIRECTION":"BI","MASTER_ID":20425,"compounds":"2-oxoglutarate + ATP + hydrogencarbonate <=> ADP + H(+) + oxalosuccinate + phosphate","pmd":43.99}
{"X":5600,"KEGG":"R08201","RHEA_ID":20428,"DIRECTION":"BI","MASTER_ID":20425,"compounds":"2-oxoglutarate + ATP + hydrogencarbonate <=> ADP + H(+) + oxalosuccinate + phosphate","pmd":79.966}
{"X":5601,"KEGG":"R08203","RHEA_ID":22679,"DIRECTION":"BI","MASTER_ID":22676,"compounds":"chlorophyllide a + H(+) + NADPH + O2 <=> 7(1)-hydroxychlorophyllide a + H2O + NADP(+)","pmd":15.995}
{"X":5602,"KEGG":"R08203","RHEA_ID":22679,"DIRECTION":"BI","MASTER_ID":22676,"compounds":"chlorophyllide a + H(+) + NADPH + O2 <=> 7(1)-hydroxychlorophyllide a + H2O + NADP(+)","pmd":114.858}
{"X":5603,"KEGG":"R08204","RHEA_ID":22139,"DIRECTION":"BI","MASTER_ID":22136,"compounds":"7(1)-hydroxychlorophyllide a + H(+) + NADPH + O2 <=> chlorophyllide b + 2 H2O + NADP(+)","pmd":116.874}
{"X":5604,"KEGG":"R08204","RHEA_ID":22139,"DIRECTION":"BI","MASTER_ID":22136,"compounds":"7(1)-hydroxychlorophyllide a + H(+) + NADPH + O2 <=> chlorophyllide b + 2 H2O + NADP(+)","pmd":2.016}
{"X":5605,"KEGG":"R08205","RHEA_ID":19564,"DIRECTION":"BI","MASTER_ID":19561,"compounds":"androst-4-ene-3,17-dione + H(+) + NADPH + O2 <=> H2O + NADP(+) + testololactone","pmd":442.903}
{"X":5606,"KEGG":"R08205","RHEA_ID":19564,"DIRECTION":"BI","MASTER_ID":19561,"compounds":"androst-4-ene-3,17-dione + H(+) + NADPH + O2 <=> H2O + NADP(+) + testololactone","pmd":15.995}
{"X":5607,"KEGG":"R08206","RHEA_ID":21631,"DIRECTION":"BI","MASTER_ID":21628,"compounds":"17alpha-hydroxyprogesterone + NADPH + O2 <=> acetate + androst-4-ene-3,17-dione + H2O + NADP(+)","pmd":458.898}
{"X":5608,"KEGG":"R08206","RHEA_ID":21631,"DIRECTION":"BI","MASTER_ID":21628,"compounds":"17alpha-hydroxyprogesterone + NADPH + O2 <=> acetate + androst-4-ene-3,17-dione + H2O + NADP(+)","pmd":44.026}
{"X":5609,"KEGG":"R08207","RHEA_ID":19284,"DIRECTION":"BI","MASTER_ID":19281,"compounds":"(7S)-marmesin + O2 + reduced [NADPH--hemoprotein reductase] <=> acetone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + psoralen","pmd":60.058}
{"X":5610,"KEGG":"R08208","RHEA_ID":32630,"DIRECTION":"BI","MASTER_ID":32627,"compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH","pmd":4.031}
{"X":5611,"KEGG":"R08208","RHEA_ID":32630,"DIRECTION":"BI","MASTER_ID":32627,"compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH","pmd":506.997}
{"X":5612,"KEGG":"R08210","RHEA_ID":24828,"DIRECTION":"BI","MASTER_ID":24825,"compounds":"dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]","pmd":15.995}
{"X":5613,"KEGG":"R08211","RHEA_ID":20372,"DIRECTION":"BI","MASTER_ID":20369,"compounds":"betaine aldehyde + H2O + O2 <=> betaine + H(+) + H2O2","pmd":14.987}
{"X":5614,"KEGG":"R08212","RHEA_ID":11539,"DIRECTION":"BI","MASTER_ID":11536,"compounds":"choline + H2O + 2 O2 <=> betaine + H(+) + 2 H2O2","pmd":12.971}
{"X":5615,"KEGG":"R08218","RHEA_ID":42583,"DIRECTION":"BI","MASTER_ID":42580,"compounds":"ATP + L-serine + tRNA(Sec) <=> AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)","pmd":242.021}
{"X":5616,"KEGG":"R08218","RHEA_ID":42583,"DIRECTION":"BI","MASTER_ID":42580,"compounds":"ATP + L-serine + tRNA(Sec) <=> AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)","pmd":159.933}
{"X":5617,"KEGG":"R08219","RHEA_ID":22731,"DIRECTION":"BI","MASTER_ID":22728,"compounds":"H(+) + L-seryl-tRNA(Sec) + selenophosphate <=> L-selenocysteinyl-tRNA(Sec) + phosphate"}
{"X":5618,"KEGG":"R08223","RHEA_ID":25040,"DIRECTION":"BI","MASTER_ID":25037,"metacyc":"RXN-10038","compounds":"ATP + L-seryl-tRNA(Sec) <=> ADP + O-phospho-L-seryl-tRNA(Sec)","pmd":79.966}
{"X":5619,"KEGG":"R08224","RHEA_ID":25044,"DIRECTION":"BI","MASTER_ID":25041,"compounds":"H2O + O-phospho-L-seryl-tRNA(Sec) + selenophosphate <=> L-selenocysteinyl-tRNA(Sec) + 2 phosphate"}
{"X":5620,"KEGG":"R08236","RHEA_ID":12612,"DIRECTION":"BI","MASTER_ID":12609,"compounds":"mercaptopurine + S-adenosyl-L-methionine <=> 6-methylthiopurine + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5621,"KEGG":"R08247","RHEA_ID":25435,"DIRECTION":"BI","MASTER_ID":25432,"ecocyc":"RXN0-5304","metacyc":"RXN0-5304","compounds":"beta-D-ribopyranose <=> beta-D-ribofuranose","pmd":0}
{"X":5622,"KEGG":"R08331","RHEA_ID":44927,"DIRECTION":"BI","MASTER_ID":44924,"compounds":"2-oxoadipate + acetyl-CoA + H2O <=> (R)-dihomocitrate + CoA + H(+)","pmd":60.021}
{"X":5623,"KEGG":"R08331","RHEA_ID":44927,"DIRECTION":"BI","MASTER_ID":44924,"compounds":"2-oxoadipate + acetyl-CoA + H2O <=> (R)-dihomocitrate + CoA + H(+)","pmd":42.011}
{"X":5624,"KEGG":"R08332","RHEA_ID":44931,"DIRECTION":"BI","MASTER_ID":44928,"compounds":"2-oxoheptanedioate + acetyl-CoA + H2O <=> (R)-trihomocitrate + CoA + H(+)","pmd":60.021}
{"X":5625,"KEGG":"R08332","RHEA_ID":44931,"DIRECTION":"BI","MASTER_ID":44928,"compounds":"2-oxoheptanedioate + acetyl-CoA + H2O <=> (R)-trihomocitrate + CoA + H(+)","pmd":42.011}
{"X":5626,"KEGG":"R08359","RHEA_ID":33390,"DIRECTION":"BI","MASTER_ID":33387,"compounds":"cadaverine + S-adenosyl 3-(methylsulfanyl)propylamine <=> aminopropylcadaverine + H(+) + S-methyl-5'-thioadenosine","pmd":58.066}
{"X":5627,"KEGG":"R08359","RHEA_ID":33390,"DIRECTION":"BI","MASTER_ID":33387,"compounds":"cadaverine + S-adenosyl 3-(methylsulfanyl)propylamine <=> aminopropylcadaverine + H(+) + S-methyl-5'-thioadenosine","pmd":57.058}
{"X":5628,"KEGG":"R08365","RHEA_ID":47683,"DIRECTION":"BI","MASTER_ID":47680,"compounds":"D-galactosamine 6-phosphate + H2O <=> D-tagatose 6-phosphate + NH4(+)","pmd":0.984}
{"X":5629,"KEGG":"R08368","RHEA_ID":19808,"DIRECTION":"BI","MASTER_ID":19805,"ecocyc":"PNP-RXN","metacyc":"PNP-RXN","compounds":"a purine D-ribonucleoside + phosphate <=> a purine nucleobase + alpha-D-ribose 1-phosphate","pmd":22.067}
{"X":5630,"KEGG":"R08370","RHEA_ID":25439,"DIRECTION":"BI","MASTER_ID":25436,"compounds":"(2E,6E)-farnesyl diphosphate <=> (E,R)-alpha-bisabolene + diphosphate","pmd":177.943}
{"X":5631,"KEGG":"R08372","RHEA_ID":36262,"DIRECTION":"BI","MASTER_ID":36259,"compounds":"a 1-(1-hydroxyalkyl)-sn-glycerol <=> an aldehyde + glycerol"}
{"X":5632,"KEGG":"R08373","RHEA_ID":31898,"DIRECTION":"BI","MASTER_ID":31895,"compounds":"(2E,6E)-farnesyl diphosphate <=> (1E,4E,8E)-alpha-humulene + diphosphate","pmd":177.943}
{"X":5633,"KEGG":"R08374","RHEA_ID":27533,"DIRECTION":"BI","MASTER_ID":27530,"compounds":"(2E,6E)-farnesyl diphosphate + H2O <=> (3S,6E)-nerolidol + diphosphate","pmd":159.933}
{"X":5634,"KEGG":"R08379","RHEA_ID":25036,"DIRECTION":"BI","MASTER_ID":25033,"metacyc":"RXN-10841","compounds":"all-trans-retinol + NADP(+) <=> all-trans-retinal + H(+) + NADPH","pmd":459.869}
{"X":5635,"KEGG":"R08379","RHEA_ID":25036,"DIRECTION":"BI","MASTER_ID":25033,"metacyc":"RXN-10841","compounds":"all-trans-retinol + NADP(+) <=> all-trans-retinal + H(+) + NADPH","pmd":2.016}
{"X":5636,"KEGG":"R08380","RHEA_ID":54915,"DIRECTION":"BI","MASTER_ID":54912,"metacyc":"RXN-13363","compounds":"11-cis-retinol + NADP(+) <=> 11-cis-retinal + H(+) + NADPH","pmd":2.016}
{"X":5637,"KEGG":"R08380","RHEA_ID":54915,"DIRECTION":"BI","MASTER_ID":54912,"metacyc":"RXN-13363","compounds":"11-cis-retinol + NADP(+) <=> 11-cis-retinal + H(+) + NADPH","pmd":459.869}
{"X":5638,"KEGG":"R08382","RHEA_ID":42055,"DIRECTION":"BI","MASTER_ID":42052,"metacyc":"RXN-12562","compounds":"9-cis-retinol + NAD(+) <=> 9-cis-retinal + H(+) + NADH","pmd":379.903}
{"X":5639,"KEGG":"R08382","RHEA_ID":42055,"DIRECTION":"BI","MASTER_ID":42052,"metacyc":"RXN-12562","compounds":"9-cis-retinol + NAD(+) <=> 9-cis-retinal + H(+) + NADH","pmd":2.016}
{"X":5640,"KEGG":"R08383","RHEA_ID":54919,"DIRECTION":"BI","MASTER_ID":54916,"compounds":"9-cis-retinol + NADP(+) <=> 9-cis-retinal + H(+) + NADPH","pmd":2.016}
{"X":5641,"KEGG":"R08383","RHEA_ID":54919,"DIRECTION":"BI","MASTER_ID":54916,"compounds":"9-cis-retinol + NADP(+) <=> 9-cis-retinal + H(+) + NADPH","pmd":459.869}
{"X":5642,"KEGG":"R08386","RHEA_ID":20280,"DIRECTION":"BI","MASTER_ID":20277,"ecocyc":"2.3.1.118-RXN","metacyc":"2.3.1.118-RXN","compounds":"acetyl-CoA + an N-hydroxyarylamine <=> an N-acetoxyarylamine + CoA","pmd":42.011}
{"X":5643,"KEGG":"R08388","RHEA_ID":31774,"DIRECTION":"BI","MASTER_ID":31771,"compounds":"an all-trans-retinyl ester + H2O <=> 11-cis-retinol + a fatty acid + H(+)"}
{"X":5644,"KEGG":"R08396","RHEA_ID":32682,"DIRECTION":"BI","MASTER_ID":32679,"compounds":"(2E)-geranyl diphosphate + H2O <=> diphosphate + geraniol","pmd":159.933}
{"X":5645,"KEGG":"R08400","RHEA_ID":18804,"DIRECTION":"BI","MASTER_ID":18801,"metacyc":"2.5.1.20-RXN","compounds":"(cis-prenyl)n-diphosphate + isopentenyl diphosphate <=> (cis-prenyl)(n+1)-diphosphate + diphosphate"}
{"X":5646,"KEGG":"R08433","RHEA_ID":45215,"DIRECTION":"BI","MASTER_ID":45212,"compounds":"[Co(I) corrinoid Fe-S protein] + acetyl-CoA + H(+) <=> [methyl-Co(III) corrinoid Fe-S protein] + CO + CoA","pmd":42.011}
{"X":5647,"KEGG":"R08437","RHEA_ID":51271,"DIRECTION":"BI","MASTER_ID":51268,"compounds":"norbelladine + S-adenosyl-L-methionine <=> 4'-O-methylnorbelladine + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5648,"KEGG":"R08468","RHEA_ID":36426,"DIRECTION":"BI","MASTER_ID":36423,"compounds":"2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine <=> 2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5649,"KEGG":"R08469","RHEA_ID":36430,"DIRECTION":"BI","MASTER_ID":36427,"compounds":"2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine <=> diphthine-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5650,"KEGG":"R08499","RHEA_ID":32662,"DIRECTION":"BI","MASTER_ID":32659,"compounds":"(6E)-8-hydroxygeraniol + 2 NADP(+) <=> (6E)-8-oxogeranial + 2 H(+) + 2 NADPH","pmd":577.984}
{"X":5651,"KEGG":"R08499","RHEA_ID":32662,"DIRECTION":"BI","MASTER_ID":32659,"compounds":"(6E)-8-hydroxygeraniol + 2 NADP(+) <=> (6E)-8-oxogeranial + 2 H(+) + 2 NADPH","pmd":4.031}
{"X":5652,"KEGG":"R08503","RHEA_ID":25843,"DIRECTION":"BI","MASTER_ID":25840,"metacyc":"RXN-14150","compounds":"5-deoxy-D-glucuronate <=> 5-dehydro-2-deoxy-D-gluconate","pmd":0}
{"X":5653,"KEGG":"R08517","RHEA_ID":50247,"DIRECTION":"BI","MASTER_ID":50244,"compounds":"17alpha-hydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta-hydroxyandrost-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":44.026}
{"X":5654,"KEGG":"R08522","RHEA_ID":48971,"DIRECTION":"BI","MASTER_ID":48968,"compounds":"[thyroglobulin]-3,5-diiodo-L-tyrosine + [thyroglobulin]-3-iodo-L-tyrosine + H2O2 <=> [thyroglobulin]-3,3',5-triiodo-L-thyronine + [thyroglobulin]-dehydroalanine + 2 H2O"}
{"X":5655,"KEGG":"R08523","RHEA_ID":48967,"DIRECTION":"BI","MASTER_ID":48964,"compounds":"2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 <=> [thyroglobulin]-dehydroalanine + [thyroglobulin]-L-thyroxine + 2 H2O"}
{"X":5656,"KEGG":"R08527","RHEA_ID":32310,"DIRECTION":"BI","MASTER_ID":32307,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> H2O + leukotriene A4","pmd":13.979}
{"X":5657,"KEGG":"R08528","RHEA_ID":23303,"DIRECTION":"BI","MASTER_ID":23300,"compounds":"(2E)-geranyl diphosphate + isopentenyl diphosphate <=> (2Z,6E)-farnesyl diphosphate + diphosphate","pmd":136.125}
{"X":5658,"KEGG":"R08528","RHEA_ID":23303,"DIRECTION":"BI","MASTER_ID":23300,"compounds":"(2E)-geranyl diphosphate + isopentenyl diphosphate <=> (2Z,6E)-farnesyl diphosphate + diphosphate","pmd":68.063}
{"X":5659,"KEGG":"R08538","RHEA_ID":18864,"DIRECTION":"BI","MASTER_ID":18861,"compounds":"a 5-hydroxyfurocoumarin + S-adenosyl-L-methionine <=> a 5-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5660,"KEGG":"R08538","RHEA_ID":24897,"DIRECTION":"BI","MASTER_ID":24894,"compounds":"5-hydroxyxanthotoxin + S-adenosyl-L-methionine <=> isopimpinellin + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5661,"KEGG":"R08540","RHEA_ID":25459,"DIRECTION":"BI","MASTER_ID":25456,"compounds":"(2E,6E)-farnesyl diphosphate <=> diphosphate + gamma-humulene","pmd":177.943}
{"X":5662,"KEGG":"R08541","RHEA_ID":28297,"DIRECTION":"BI","MASTER_ID":28294,"compounds":"(2E,6E)-farnesyl diphosphate <=> (-)-beta-caryophyllene + diphosphate","pmd":177.943}
{"X":5663,"KEGG":"R08542","RHEA_ID":25467,"DIRECTION":"BI","MASTER_ID":25464,"compounds":"(2E,6E)-farnesyl diphosphate <=> diphosphate + longifolene","pmd":177.943}
{"X":5664,"KEGG":"R08544","RHEA_ID":42395,"DIRECTION":"BI","MASTER_ID":42392,"metacyc":"RXN-14234","compounds":"D-galactose + NAD(+) <=> D-galactono-1,5-lactone + H(+) + NADH","pmd":486.069}
{"X":5665,"KEGG":"R08544","RHEA_ID":42395,"DIRECTION":"BI","MASTER_ID":42392,"metacyc":"RXN-14234","compounds":"D-galactose + NAD(+) <=> D-galactono-1,5-lactone + H(+) + NADH","pmd":2.016}
{"X":5666,"KEGG":"R08545","RHEA_ID":25447,"DIRECTION":"BI","MASTER_ID":25444,"compounds":"(2E,6E)-farnesyl diphosphate <=> (1E,4E)-germacrene B + diphosphate","pmd":177.943}
{"X":5667,"KEGG":"R08546","RHEA_ID":29486,"DIRECTION":"BI","MASTER_ID":29483,"compounds":"(2E,6E)-farnesyl diphosphate <=> (+)-beta-selinene + diphosphate","pmd":177.943}
{"X":5668,"KEGG":"R08547","RHEA_ID":17324,"DIRECTION":"BI","MASTER_ID":17321,"compounds":"L-tryptophan + S-adenosyl-L-methionine <=> 2-methyl-L-tryptophan + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5669,"KEGG":"R08548","RHEA_ID":35606,"DIRECTION":"BI","MASTER_ID":35603,"compounds":"beta-D-fructose 1-phosphate + H2O <=> D-fructose + phosphate","pmd":79.966}
{"X":5670,"KEGG":"R08549","RHEA_ID":27789,"DIRECTION":"BI","MASTER_ID":27786,"compounds":"2-oxoglutarate + CoA + NAD(+) <=> CO2 + NADH + succinyl-CoA","pmd":203.014}
{"X":5671,"KEGG":"R08549","RHEA_ID":27789,"DIRECTION":"BI","MASTER_ID":27786,"compounds":"2-oxoglutarate + CoA + NAD(+) <=> CO2 + NADH + succinyl-CoA","pmd":519.103}
{"X":5672,"KEGG":"R08549","RHEA_ID":27789,"DIRECTION":"BI","MASTER_ID":27786,"compounds":"2-oxoglutarate + CoA + NAD(+) <=> CO2 + NADH + succinyl-CoA","pmd":100.016}
{"X":5673,"KEGG":"R08550","RHEA_ID":15048,"DIRECTION":"BI","MASTER_ID":15045,"compounds":"(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) <=> (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH"}
{"X":5674,"KEGG":"R08555","RHEA_ID":26413,"DIRECTION":"BI","MASTER_ID":26410,"ecocyc":"RXN0-4641","metacyc":"RXN0-4641","compounds":"H2O + N-acetyl-D-muramate 6-phosphate <=> (R)-lactate + N-acetyl-D-glucosamine 6-phosphate","pmd":72.021}
{"X":5675,"KEGG":"R08557","RHEA_ID":33054,"DIRECTION":"BI","MASTER_ID":33051,"compounds":"choline + NAD(+) <=> betaine aldehyde + H(+) + NADH","pmd":2.016}
{"X":5676,"KEGG":"R08557","RHEA_ID":33054,"DIRECTION":"BI","MASTER_ID":33051,"compounds":"choline + NAD(+) <=> betaine aldehyde + H(+) + NADH","pmd":562.025}
{"X":5677,"KEGG":"R08559","RHEA_ID":33402,"DIRECTION":"BI","MASTER_ID":33399,"compounds":"N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-muramate(out) <=> L-histidyl-[protein] + N-acetyl-beta-D-muramate 6-phosphate(in)","pmd":79.966}
{"X":5678,"KEGG":"R08568","RHEA_ID":25955,"DIRECTION":"BI","MASTER_ID":25952,"compounds":"1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + L-aspartate 4-semialdehyde <=> 2,3-dioxopropyl phosphate + 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate","pmd":50.94}
{"X":5679,"KEGG":"R08569","RHEA_ID":25959,"DIRECTION":"BI","MASTER_ID":25956,"compounds":"2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) <=> 3-dehydroquinate + H(+) + NADH + NH4(+)","pmd":1.032}
{"X":5680,"KEGG":"R08569","RHEA_ID":25959,"DIRECTION":"BI","MASTER_ID":25956,"compounds":"2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) <=> 3-dehydroquinate + H(+) + NADH + NH4(+)","pmd":474.069}
{"X":5681,"KEGG":"R08570","RHEA_ID":35586,"DIRECTION":"BI","MASTER_ID":35583,"ecocyc":"DHDOGALDOL-RXN","metacyc":"DHDOGALDOL-RXN","compounds":"2-dehydro-3-deoxy-D-gluconate <=> D-glyceraldehyde + pyruvate"}
{"X":5682,"KEGG":"R08573","RHEA_ID":18008,"DIRECTION":"BI","MASTER_ID":18005,"metacyc":"RXN-17773","compounds":"D-threitol + NADP(+) <=> D-erythrulose + H(+) + NADPH","pmd":624.041}
{"X":5683,"KEGG":"R08573","RHEA_ID":18008,"DIRECTION":"BI","MASTER_ID":18005,"metacyc":"RXN-17773","compounds":"D-threitol + NADP(+) <=> D-erythrulose + H(+) + NADPH","pmd":2.016}
{"X":5684,"KEGG":"R08574","RHEA_ID":25024,"DIRECTION":"BI","MASTER_ID":25021,"compounds":"CTP + riboflavin <=> CDP + FMN + H(+)","pmd":26.88}
{"X":5685,"KEGG":"R08576","RHEA_ID":25681,"DIRECTION":"BI","MASTER_ID":25678,"compounds":"ATP + O-phospho-L-serine + tRNA(Cys) <=> AMP + diphosphate + O-phospho-L-seryl-tRNA(Cys)","pmd":159.933}
{"X":5686,"KEGG":"R08576","RHEA_ID":25681,"DIRECTION":"BI","MASTER_ID":25678,"compounds":"ATP + O-phospho-L-serine + tRNA(Cys) <=> AMP + diphosphate + O-phospho-L-seryl-tRNA(Cys)","pmd":162.054}
{"X":5687,"KEGG":"R08577","RHEA_ID":25689,"DIRECTION":"BI","MASTER_ID":25686,"compounds":"H(+) + hydrogen sulfide + O-phospho-L-seryl-tRNA(Cys) <=> L-cysteinyl-tRNA(Cys) + phosphate"}
{"X":5688,"KEGG":"R08578","RHEA_ID":19280,"DIRECTION":"BI","MASTER_ID":19277,"compounds":"ATP + L-pyrrolysine + tRNA(Pyl) <=> AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl)","pmd":159.933}
{"X":5689,"KEGG":"R08578","RHEA_ID":19280,"DIRECTION":"BI","MASTER_ID":19277,"compounds":"ATP + L-pyrrolysine + tRNA(Pyl) <=> AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl)","pmd":91.905}
{"X":5690,"KEGG":"R08583","RHEA_ID":39650,"DIRECTION":"BI","MASTER_ID":39647,"compounds":"AH2 + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + A + dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + H(+) + L-methionine + NH4(+)","pmd":131.933}
{"X":5691,"KEGG":"R08583","RHEA_ID":39650,"DIRECTION":"BI","MASTER_ID":39647,"compounds":"AH2 + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + A + dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + H(+) + L-methionine + NH4(+)","pmd":17.027}
{"X":5692,"KEGG":"R08584","RHEA_ID":52791,"DIRECTION":"BI","MASTER_ID":52788,"compounds":"chlorophyll a + 2 H(+) <=> Mg(2+) + pheophytin a","pmd":21.969}
{"X":5693,"KEGG":"R08600","RHEA_ID":25567,"DIRECTION":"BI","MASTER_ID":25564,"compounds":"H2O + N-acetyl-4-O-acetylneuraminate <=> acetate + H(+) + N-acetylneuraminate","pmd":42.01}
{"X":5694,"KEGG":"R08601","RHEA_ID":22603,"DIRECTION":"BI","MASTER_ID":22600,"compounds":"H2O + N-acetyl-9-O-acetylneuraminate <=> acetate + H(+) + N-acetylneuraminate","pmd":42.01}
{"X":5695,"KEGG":"R08603","RHEA_ID":25839,"DIRECTION":"BI","MASTER_ID":25836,"compounds":"3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O <=> 5-deoxy-D-glucuronate + H(+)","pmd":18.01}
{"X":5696,"KEGG":"R08615","RHEA_ID":26076,"DIRECTION":"BI","MASTER_ID":26073,"compounds":"H2O + UDP-alpha-D-glucuronate <=> D-glucuronate + H(+) + UDP","pmd":176.032}
{"X":5697,"KEGG":"R08617","RHEA_ID":33074,"DIRECTION":"BI","MASTER_ID":33071,"compounds":"D-glucose 6-phosphate <=> 2-deoxy-L-scyllo-inosose + phosphate","pmd":97.977}
{"X":5698,"KEGG":"R08619","RHEA_ID":25604,"DIRECTION":"BI","MASTER_ID":25601,"compounds":"4-methylsulfanyl-2-oxobutanoate + acetyl-CoA + H2O <=> 2-(2-methylsulfanyl)ethylmalate + CoA + H(+)","pmd":42.011}
{"X":5699,"KEGG":"R08619","RHEA_ID":25604,"DIRECTION":"BI","MASTER_ID":25601,"compounds":"4-methylsulfanyl-2-oxobutanoate + acetyl-CoA + H2O <=> 2-(2-methylsulfanyl)ethylmalate + CoA + H(+)","pmd":60.021}
{"X":5700,"KEGG":"R08620","RHEA_ID":50643,"DIRECTION":"BI","MASTER_ID":50640,"compounds":"2-(2-methylsulfanyl)ethylmalate <=> 3-(2-methylsulfanyl)ethylmalate","pmd":0}
{"X":5701,"KEGG":"R08624","RHEA_ID":50647,"DIRECTION":"BI","MASTER_ID":50644,"compounds":"2-(3-methylsulfanyl)propylmalate <=> 3-(3-methylsulfanyl)propylmalate","pmd":0}
{"X":5702,"KEGG":"R08632","RHEA_ID":24913,"DIRECTION":"BI","MASTER_ID":24910,"compounds":"L,L-cystathionine <=> 2-aminobut-2-enoate + L-cysteine","pmd":101.048}
{"X":5703,"KEGG":"R08633","RHEA_ID":43015,"DIRECTION":"BI","MASTER_ID":43012,"compounds":"L-homocysteine <=> 2-aminobut-2-enoate + H(+) + hydrogen sulfide","pmd":33.988}
{"X":5704,"KEGG":"R08635","RHEA_ID":24749,"DIRECTION":"BI","MASTER_ID":24746,"compounds":"L-methionine <=> 2-aminobut-2-enoate + methanethiol","pmd":48.003}
{"X":5705,"KEGG":"R08637","RHEA_ID":24745,"DIRECTION":"BI","MASTER_ID":24742,"compounds":"2-aminobut-2-enoate + H2O <=> 2-oxobutanoate + NH4(+)","pmd":0.984}
{"X":5706,"KEGG":"R08648","RHEA_ID":27657,"DIRECTION":"BI","MASTER_ID":27654,"compounds":"2-oxobutanoate + H(+) + pyruvate <=> (S)-2-ethyl-2-hydroxy-3-oxobutanoate + CO2","pmd":44.026}
{"X":5707,"KEGG":"R08652","RHEA_ID":33266,"DIRECTION":"BI","MASTER_ID":33263,"compounds":"L-phenylalanine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-phenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]","pmd":30.011}
{"X":5708,"KEGG":"R08657","RHEA_ID":28758,"DIRECTION":"BI","MASTER_ID":28755,"compounds":"a ubiquinone + sn-glycerol 3-phosphate <=> a ubiquinol + dihydroxyacetone phosphate","pmd":2.016}
{"X":5709,"KEGG":"R08658","RHEA_ID":11479,"DIRECTION":"BI","MASTER_ID":11476,"compounds":"glycerol 1-phosphate + H2O <=> glycerol + phosphate"}
{"X":5710,"KEGG":"R08663","RHEA_ID":28609,"DIRECTION":"BI","MASTER_ID":28606,"compounds":"L-valine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-2-methylpropanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":5711,"KEGG":"R08670","RHEA_ID":32722,"DIRECTION":"BI","MASTER_ID":32719,"compounds":"L-dihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-5-(methylsulfanyl)pentanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]","pmd":30.011}
{"X":5712,"KEGG":"R08672","RHEA_ID":32726,"DIRECTION":"BI","MASTER_ID":32723,"compounds":"L-trihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-6-(methylsulfanyl)hexanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]","pmd":30.011}
{"X":5713,"KEGG":"R08673","RHEA_ID":33246,"DIRECTION":"BI","MASTER_ID":33243,"compounds":"L-tetrahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-7-(methylsulfanyl)heptanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]","pmd":30.011}
{"X":5714,"KEGG":"R08674","RHEA_ID":33294,"DIRECTION":"BI","MASTER_ID":33291,"compounds":"L-pentahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-8-(methylsulfanyl)octanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]","pmd":30.011}
{"X":5715,"KEGG":"R08675","RHEA_ID":33298,"DIRECTION":"BI","MASTER_ID":33295,"compounds":"L-hexahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-9-(methylsulfanyl)nonanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]","pmd":30.011}
{"X":5716,"KEGG":"R08676","RHEA_ID":55083,"DIRECTION":"BI","MASTER_ID":55080,"compounds":"ADP-alpha-D-glucose + D-fructose <=> ADP + H(+) + sucrose","pmd":162.053}
{"X":5717,"KEGG":"R08678","RHEA_ID":12984,"DIRECTION":"BI","MASTER_ID":12981,"compounds":"H2O + O2 + S-sulfanylglutathione <=> glutathione + 2 H(+) + sulfite","pmd":31.972}
{"X":5718,"KEGG":"R08689","RHEA_ID":26122,"DIRECTION":"BI","MASTER_ID":26119,"compounds":"(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]","pmd":15.995}
{"X":5719,"KEGG":"R08691","RHEA_ID":29514,"DIRECTION":"BI","MASTER_ID":29511,"compounds":"(2E,6E)-farnesyl diphosphate <=> (+)-valencene + diphosphate","pmd":177.943}
{"X":5720,"KEGG":"R08692","RHEA_ID":46879,"DIRECTION":"BI","MASTER_ID":46876,"compounds":"[(1->4)-beta-D-mannuronosyl](n) + GDP-alpha-D-mannuronate <=> [(1->4)-beta-D-mannuronosyl](n+1) + GDP + H(+)","pmd":176.032}
{"X":5721,"KEGG":"R08693","RHEA_ID":45575,"DIRECTION":"BI","MASTER_ID":45572,"compounds":"[(1->4)-beta-D-mannuronosyl](n) <=> [alginate](n)"}
{"X":5722,"KEGG":"R08711","RHEA_ID":34566,"DIRECTION":"BI","MASTER_ID":34563,"metacyc":"RXN-9158","compounds":"CDP-alpha-D-abequose + NADP(+) <=> CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH","pmd":212.01}
{"X":5723,"KEGG":"R08711","RHEA_ID":34566,"DIRECTION":"BI","MASTER_ID":34563,"metacyc":"RXN-9158","compounds":"CDP-alpha-D-abequose + NADP(+) <=> CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH","pmd":2.016}
{"X":5724,"KEGG":"R08712","RHEA_ID":25519,"DIRECTION":"BI","MASTER_ID":25516,"compounds":"an acyl-CoA + tropine <=> CoA + H(+) + O-acyltropine","pmd":626}
{"X":5725,"KEGG":"R08713","RHEA_ID":25523,"DIRECTION":"BI","MASTER_ID":25520,"compounds":"an acyl-CoA + pseudotropine <=> CoA + H(+) + O-acylpseudotropine","pmd":626}
{"X":5726,"KEGG":"R08714","RHEA_ID":30710,"DIRECTION":"BI","MASTER_ID":30707,"metacyc":"RXN-8","compounds":"putrescine + pyruvate <=> 4-aminobutanal + L-alanine"}
{"X":5727,"KEGG":"R08723","RHEA_ID":47159,"DIRECTION":"BI","MASTER_ID":47156,"compounds":"7alpha,25-dihydroxycholesterol + NAD(+) <=> 7alpha,25-dihydroxy-4-cholesten-3-one + H(+) + NADH","pmd":247.788}
{"X":5728,"KEGG":"R08723","RHEA_ID":47159,"DIRECTION":"BI","MASTER_ID":47156,"compounds":"7alpha,25-dihydroxycholesterol + NAD(+) <=> 7alpha,25-dihydroxy-4-cholesten-3-one + H(+) + NADH","pmd":2.016}
{"X":5729,"KEGG":"R08761","RHEA_ID":34630,"DIRECTION":"BI","MASTER_ID":34627,"compounds":"(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + H2O + 2 oxidized [adrenodoxin]","pmd":15.995}
{"X":5730,"KEGG":"R08762","RHEA_ID":14684,"DIRECTION":"BI","MASTER_ID":14681,"metacyc":"O-AMINOPHENOL-OXIDASE-RXN","compounds":"2 2-aminophenol + A + O2 <=> 2-aminophenoxazin-3-one + AH2 + 2 H2O","pmd":2.016}
{"X":5731,"KEGG":"R08763","RHEA_ID":15788,"DIRECTION":"BI","MASTER_ID":15785,"compounds":"2 6-iminocyclohexa-2,4-dienone + A <=> 2-aminophenoxazin-3-one + AH2","pmd":105.022}
{"X":5732,"KEGG":"R08764","RHEA_ID":27336,"DIRECTION":"BI","MASTER_ID":27333,"compounds":"6-hydroxynicotinate + 2 H(+) + NADH + O2 <=> 2,5-dihydroxypyridine + CO2 + H2O + NAD(+)","pmd":554.093}
{"X":5733,"KEGG":"R08764","RHEA_ID":27336,"DIRECTION":"BI","MASTER_ID":27333,"compounds":"6-hydroxynicotinate + 2 H(+) + NADH + O2 <=> 2,5-dihydroxypyridine + CO2 + H2O + NAD(+)","pmd":27.995}
{"X":5734,"KEGG":"R08765","RHEA_ID":10675,"DIRECTION":"BI","MASTER_ID":10672,"compounds":"cyclobutadithymidine in DNA <=> a thymidine dimer in DNA"}
{"X":5735,"KEGG":"R08768","RHEA_ID":55895,"DIRECTION":"BI","MASTER_ID":55892,"compounds":"a 2-all-trans-polyprenylphenol + H(+) + NADPH + O2 <=> a 3-(all-trans-polyprenyl)benzene-1,2-diol + H2O + NADP(+)"}
{"X":5736,"KEGG":"R08769","RHEA_ID":31414,"DIRECTION":"BI","MASTER_ID":31411,"metacyc":"RXN-12160","compounds":"a 3-(all-trans-polyprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> a 2-methoxy-6-(all-trans-polyprenyl)phenol + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5737,"KEGG":"R08771","RHEA_ID":44455,"DIRECTION":"BI","MASTER_ID":44452,"compounds":"3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L-methionine <=> 3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5738,"KEGG":"R08776","RHEA_ID":30438,"DIRECTION":"BI","MASTER_ID":30435,"compounds":"beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + glycyl-tRNA(Gly) <=> beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + H(+) + tRNA(Gly)"}
{"X":5739,"KEGG":"R08777","RHEA_ID":30442,"DIRECTION":"BI","MASTER_ID":30439,"compounds":"beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + 2 glycyl-tRNA(Gly) <=> 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly)"}
{"X":5740,"KEGG":"R08778","RHEA_ID":30446,"DIRECTION":"BI","MASTER_ID":30443,"compounds":"2 glycyl-tRNA(Gly) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc <=> 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-penta-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly)"}
{"X":5741,"KEGG":"R08781","RHEA_ID":44383,"DIRECTION":"BI","MASTER_ID":44380,"compounds":"a 3-demethylubiquinol + S-adenosyl-L-methionine <=> a ubiquinol + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5742,"KEGG":"R08782","RHEA_ID":37998,"DIRECTION":"BI","MASTER_ID":37995,"compounds":"all-trans-nonaprenyl diphosphate + H(+) + homogentisate <=> 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2 + diphosphate","pmd":568.573}
{"X":5743,"KEGG":"R08782","RHEA_ID":37998,"DIRECTION":"BI","MASTER_ID":37995,"compounds":"all-trans-nonaprenyl diphosphate + H(+) + homogentisate <=> 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2 + diphosphate","pmd":53.891}
{"X":5744,"KEGG":"R08784","RHEA_ID":32902,"DIRECTION":"BI","MASTER_ID":32899,"compounds":"1,8-cineole + O2 + reduced [flavodoxin] <=> 2-endo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [flavodoxin]","pmd":15.995}
{"X":5745,"KEGG":"R08785","RHEA_ID":32498,"DIRECTION":"BI","MASTER_ID":32495,"compounds":"geraniol + O2 + reduced [NADPH--hemoprotein reductase] <=> (6E)-8-hydroxygeraniol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":5746,"KEGG":"R08787","RHEA_ID":10447,"DIRECTION":"BI","MASTER_ID":10444,"compounds":"(S)-reticuline + S-adenosyl-L-methionine <=> (S)-laudanine + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5747,"KEGG":"R08788","RHEA_ID":38910,"DIRECTION":"BI","MASTER_ID":38907,"compounds":"(R)-reticuline + S-adenosyl-L-methionine <=> (R)-laudanine + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5748,"KEGG":"R08791","RHEA_ID":51527,"DIRECTION":"BI","MASTER_ID":51524,"compounds":"(S)-corytuberine + S-adenosyl-L-methionine <=> magnoflorine + S-adenosyl-L-homocysteine","pmd":15.023}
{"X":5749,"KEGG":"R08791","RHEA_ID":51527,"DIRECTION":"BI","MASTER_ID":51524,"compounds":"(S)-corytuberine + S-adenosyl-L-methionine <=> magnoflorine + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5750,"KEGG":"R08805","RHEA_ID":22503,"DIRECTION":"BI","MASTER_ID":22500,"compounds":"(E)-feruloyl-CoA + H(+) + malonyl-CoA <=> (E)-feruloylacetyl-CoA + CO2 + CoA","pmd":86}
{"X":5751,"KEGG":"R08805","RHEA_ID":22503,"DIRECTION":"BI","MASTER_ID":22500,"compounds":"(E)-feruloyl-CoA + H(+) + malonyl-CoA <=> (E)-feruloylacetyl-CoA + CO2 + CoA","pmd":42.011}
{"X":5752,"KEGG":"R08806","RHEA_ID":35118,"DIRECTION":"BI","MASTER_ID":35115,"compounds":"4-coumaroyl-CoA + H(+) + malonyl-CoA <=> (4-coumaroyl)acetyl-CoA + CO2 + CoA","pmd":86}
{"X":5753,"KEGG":"R08806","RHEA_ID":35118,"DIRECTION":"BI","MASTER_ID":35115,"compounds":"4-coumaroyl-CoA + H(+) + malonyl-CoA <=> (4-coumaroyl)acetyl-CoA + CO2 + CoA","pmd":42.01}
{"X":5754,"KEGG":"R08807","RHEA_ID":35142,"DIRECTION":"BI","MASTER_ID":35139,"compounds":"(E)-4-coumaroyl-CoA + (E)-feruloylacetyl-CoA + H2O <=> CO2 + 2 CoA + demethoxycurcumin","pmd":188.047}
{"X":5755,"KEGG":"R08807","RHEA_ID":35142,"DIRECTION":"BI","MASTER_ID":35139,"compounds":"(E)-4-coumaroyl-CoA + (E)-feruloylacetyl-CoA + H2O <=> CO2 + 2 CoA + demethoxycurcumin","pmd":146.037}
{"X":5756,"KEGG":"R08809","RHEA_ID":35122,"DIRECTION":"BI","MASTER_ID":35119,"compounds":"(4-coumaroyl)acetyl-CoA + 4-coumaroyl-CoA + H2O <=> bisdemethoxycurcumin + CO2 + 2 CoA","pmd":146.037}
{"X":5757,"KEGG":"R08809","RHEA_ID":35122,"DIRECTION":"BI","MASTER_ID":35119,"compounds":"(4-coumaroyl)acetyl-CoA + 4-coumaroyl-CoA + H2O <=> bisdemethoxycurcumin + CO2 + 2 CoA","pmd":218.058}
{"X":5758,"KEGG":"R08810","RHEA_ID":34826,"DIRECTION":"BI","MASTER_ID":34823,"compounds":"(E)-feruloyl-CoA + (E)-feruloylacetyl-CoA + H2O <=> CO2 + 2 CoA + curcumin","pmd":218.058}
{"X":5759,"KEGG":"R08810","RHEA_ID":34826,"DIRECTION":"BI","MASTER_ID":34823,"compounds":"(E)-feruloyl-CoA + (E)-feruloylacetyl-CoA + H2O <=> CO2 + 2 CoA + curcumin","pmd":176.047}
{"X":5760,"KEGG":"R08839","RHEA_ID":57471,"DIRECTION":"BI","MASTER_ID":57468,"compounds":"trans-ferulate + UDP-alpha-D-glucose <=> 1-O-[(E)-feruloyl]-beta-D-glucose + UDP","pmd":162.053}
{"X":5761,"KEGG":"R08845","RHEA_ID":13208,"DIRECTION":"BI","MASTER_ID":13205,"metacyc":"2.7.7.64-RXN","compounds":"a monosaccharide 1-phosphate + H(+) + UTP <=> a UDP-monosaccharide + diphosphate"}
{"X":5762,"KEGG":"R08846","RHEA_ID":24763,"DIRECTION":"BI","MASTER_ID":24760,"compounds":"H(+) + L-dopa + NADH <=> 3-(3,4-dihydroxyphenyl)propanoate + NAD(+) + NH4(+)","pmd":483.067}
{"X":5763,"KEGG":"R08846","RHEA_ID":24763,"DIRECTION":"BI","MASTER_ID":24760,"compounds":"H(+) + L-dopa + NADH <=> 3-(3,4-dihydroxyphenyl)propanoate + NAD(+) + NH4(+)","pmd":15.011}
{"X":5764,"KEGG":"R08851","RHEA_ID":25979,"DIRECTION":"BI","MASTER_ID":25976,"compounds":"(+)-epi-isozizaene + H(+) + NADPH + O2 <=> (5S)-albaflavenol + H2O + NADP(+)","pmd":524.908}
{"X":5765,"KEGG":"R08851","RHEA_ID":25979,"DIRECTION":"BI","MASTER_ID":25976,"compounds":"(+)-epi-isozizaene + H(+) + NADPH + O2 <=> (5S)-albaflavenol + H2O + NADP(+)","pmd":15.995}
{"X":5766,"KEGG":"R08852","RHEA_ID":25983,"DIRECTION":"BI","MASTER_ID":25980,"compounds":"(5S)-albaflavenol + H(+) + NADPH + O2 <=> albaflavenone + 2 H2O + NADP(+)","pmd":526.924}
{"X":5767,"KEGG":"R08852","RHEA_ID":25983,"DIRECTION":"BI","MASTER_ID":25980,"compounds":"(5S)-albaflavenol + H(+) + NADPH + O2 <=> albaflavenone + 2 H2O + NADP(+)","pmd":2.016}
{"X":5768,"KEGG":"R08853","RHEA_ID":25987,"DIRECTION":"BI","MASTER_ID":25984,"compounds":"(+)-epi-isozizaene + H(+) + NADPH + O2 <=> (5R)-albaflavenol + H2O + NADP(+)","pmd":524.908}
{"X":5769,"KEGG":"R08853","RHEA_ID":25987,"DIRECTION":"BI","MASTER_ID":25984,"compounds":"(+)-epi-isozizaene + H(+) + NADPH + O2 <=> (5R)-albaflavenol + H2O + NADP(+)","pmd":15.995}
{"X":5770,"KEGG":"R08854","RHEA_ID":25991,"DIRECTION":"BI","MASTER_ID":25988,"compounds":"(5R)-albaflavenol + H(+) + NADPH + O2 <=> albaflavenone + 2 H2O + NADP(+)","pmd":526.924}
{"X":5771,"KEGG":"R08854","RHEA_ID":25991,"DIRECTION":"BI","MASTER_ID":25988,"compounds":"(5R)-albaflavenol + H(+) + NADPH + O2 <=> albaflavenone + 2 H2O + NADP(+)","pmd":2.016}
{"X":5772,"KEGG":"R08856","RHEA_ID":28093,"DIRECTION":"BI","MASTER_ID":28090,"compounds":"di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine <=> N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UMP","pmd":283.046}
{"X":5773,"KEGG":"R08856","RHEA_ID":28093,"DIRECTION":"BI","MASTER_ID":28090,"compounds":"di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine <=> N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UMP","pmd":522.63}
{"X":5774,"KEGG":"R08863","RHEA_ID":10811,"DIRECTION":"BI","MASTER_ID":10808,"compounds":"(S)-2-hydroxypropylphosphonate + H2O2 <=> (1R,2S)-epoxypropylphosphonate + 2 H2O","pmd":2.016}
{"X":5775,"KEGG":"R08864","RHEA_ID":34794,"DIRECTION":"BI","MASTER_ID":34791,"compounds":"2-hydroxyethylphosphonate + O2 <=> formate + H(+) + hydroxymethylphosphonate","pmd":14.016}
{"X":5776,"KEGG":"R08867","RHEA_ID":49431,"DIRECTION":"BI","MASTER_ID":49428,"compounds":"CTP + phosphonoformate <=> CMP-5'-phosphonoformate + diphosphate","pmd":51.971}
{"X":5777,"KEGG":"R08867","RHEA_ID":49431,"DIRECTION":"BI","MASTER_ID":49428,"compounds":"CTP + phosphonoformate <=> CMP-5'-phosphonoformate + diphosphate","pmd":305.041}
{"X":5778,"KEGG":"R08879","RHEA_ID":27637,"DIRECTION":"BI","MASTER_ID":27634,"compounds":"5-dehydro-D-gluconate + NADP(+) <=> 2,5-didehydro-D-gluconate + H(+) + NADPH","pmd":2.016}
{"X":5779,"KEGG":"R08879","RHEA_ID":27637,"DIRECTION":"BI","MASTER_ID":27634,"compounds":"5-dehydro-D-gluconate + NADP(+) <=> 2,5-didehydro-D-gluconate + H(+) + NADPH","pmd":552.056}
{"X":5780,"KEGG":"R08880","RHEA_ID":29842,"DIRECTION":"BI","MASTER_ID":29839,"compounds":"2-dehydro-L-idonate + H(+) + NADPH <=> L-idonate + NADP(+)","pmd":550.041}
{"X":5781,"KEGG":"R08880","RHEA_ID":29842,"DIRECTION":"BI","MASTER_ID":29839,"compounds":"2-dehydro-L-idonate + H(+) + NADPH <=> L-idonate + NADP(+)","pmd":2.016}
{"X":5782,"KEGG":"R08889","RHEA_ID":26026,"DIRECTION":"BI","MASTER_ID":26023,"compounds":"8'-apo-beta-carotenol + O2 <=> (3E,5E)-7-hydroxy-6-methylhepta-3,5-dienal + 14'-apo-beta-carotenal","pmd":108.094}
{"X":5783,"KEGG":"R08890","RHEA_ID":34150,"DIRECTION":"BI","MASTER_ID":34147,"metacyc":"RXN-13117","compounds":"2-deoxy-L-scyllo-inosose + L-glutamine <=> 2-deoxy-scyllo-inosamine + 2-oxoglutaramate","pmd":1.032}
{"X":5784,"KEGG":"R08891","RHEA_ID":34154,"DIRECTION":"BI","MASTER_ID":34151,"metacyc":"RXN-13119","compounds":"3-amino-2,3-dideoxy-scyllo-inosose + L-glutamine <=> 2-deoxystreptamine + 2-oxoglutaramate","pmd":1.032}
{"X":5785,"KEGG":"R08892","RHEA_ID":33886,"DIRECTION":"BI","MASTER_ID":33883,"compounds":"2-deoxy-scyllo-inosamine + NAD(+) <=> 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADH","pmd":2.016}
{"X":5786,"KEGG":"R08892","RHEA_ID":33886,"DIRECTION":"BI","MASTER_ID":33883,"compounds":"2-deoxy-scyllo-inosamine + NAD(+) <=> 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADH","pmd":503.048}
{"X":5787,"KEGG":"R08893","RHEA_ID":34278,"DIRECTION":"BI","MASTER_ID":34275,"compounds":"2-deoxy-scyllo-inosamine + S-adenosyl-L-methionine <=> 3-amino-2,3-dideoxy-scyllo-inosose + 5'-deoxyadenosine + H(+) + L-methionine","pmd":2.016}
{"X":5788,"KEGG":"R08893","RHEA_ID":34278,"DIRECTION":"BI","MASTER_ID":34275,"compounds":"2-deoxy-scyllo-inosamine + S-adenosyl-L-methionine <=> 3-amino-2,3-dideoxy-scyllo-inosose + 5'-deoxyadenosine + H(+) + L-methionine","pmd":147.035}
{"X":5789,"KEGG":"R08894","RHEA_ID":33950,"DIRECTION":"BI","MASTER_ID":33947,"compounds":"2-deoxystreptamine + UDP-N-acetyl-alpha-D-glucosamine <=> 2'-N-acetylparomamine + H(+) + UDP","pmd":203.079}
{"X":5790,"KEGG":"R08895","RHEA_ID":34034,"DIRECTION":"BI","MASTER_ID":34031,"compounds":"2'-N-acetylparomamine + H2O <=> acetate + paromamine","pmd":42.01}
{"X":5791,"KEGG":"R08896","RHEA_ID":34038,"DIRECTION":"BI","MASTER_ID":34035,"compounds":"O2 + paromamine <=> 6'-oxoparomamine + H2O2","pmd":2.016}
{"X":5792,"KEGG":"R08897","RHEA_ID":34042,"DIRECTION":"BI","MASTER_ID":34039,"metacyc":"RXN-13146","compounds":"2-oxoglutarate + neamine <=> 6'-oxoparomamine + L-glutamate","pmd":1.032}
{"X":5793,"KEGG":"R08898","RHEA_ID":34046,"DIRECTION":"BI","MASTER_ID":34043,"compounds":"5-phospho-alpha-D-ribose 1-diphosphate + neamine <=> 5''-phosphoribostamycin + diphosphate","pmd":144.242}
{"X":5794,"KEGG":"R08898","RHEA_ID":34046,"DIRECTION":"BI","MASTER_ID":34043,"compounds":"5-phospho-alpha-D-ribose 1-diphosphate + neamine <=> 5''-phosphoribostamycin + diphosphate","pmd":212.009}
{"X":5795,"KEGG":"R08899","RHEA_ID":33974,"DIRECTION":"BI","MASTER_ID":33971,"compounds":"5''-phosphoribostamycin + H2O <=> phosphate + ribostamycin","pmd":79.966}
{"X":5796,"KEGG":"R08900","RHEA_ID":33954,"DIRECTION":"BI","MASTER_ID":33951,"compounds":"ribostamycin + UDP-N-acetyl-alpha-D-glucosamine <=> 2'''-acetyl-6'''-hydroxyneomycin C + H(+) + UDP","pmd":50.225}
{"X":5797,"KEGG":"R08901","RHEA_ID":34054,"DIRECTION":"BI","MASTER_ID":34051,"compounds":"2'''-acetyl-6'''-hydroxyneomycin C + H2O <=> 6'''-deamino-6'''-hydroxyneomycin C + acetate","pmd":42.011}
{"X":5798,"KEGG":"R08902","RHEA_ID":34050,"DIRECTION":"BI","MASTER_ID":34047,"compounds":"6'''-deamino-6'''-hydroxyneomycin C + O2 <=> 6'''-deamino-6'''-oxoneomycin C + H2O2","pmd":2.016}
{"X":5799,"KEGG":"R08903","RHEA_ID":33962,"DIRECTION":"BI","MASTER_ID":33959,"metacyc":"RXN-13175","compounds":"2-oxoglutarate + neomycin C <=> 6'''-deamino-6'''-oxoneomycin C + L-glutamate","pmd":1.032}
{"X":5800,"KEGG":"R08905","RHEA_ID":53951,"DIRECTION":"BI","MASTER_ID":53948,"compounds":"ATP + holo-[BtrI ACP] + L-glutamate <=> ADP + gamma-L-glutamyl-[BtrI ACP] + phosphate","pmd":79.966}
{"X":5801,"KEGG":"R08905","RHEA_ID":53951,"DIRECTION":"BI","MASTER_ID":53948,"compounds":"ATP + holo-[BtrI ACP] + L-glutamate <=> ADP + gamma-L-glutamyl-[BtrI ACP] + phosphate","pmd":279.976}
{"X":5802,"KEGG":"R08906","RHEA_ID":53955,"DIRECTION":"BI","MASTER_ID":53952,"compounds":"4-aminobutanoyl-[BtrI ACP] + ATP + L-glutamate <=> 4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + ADP + H(+) + phosphate","pmd":279.976}
{"X":5803,"KEGG":"R08906","RHEA_ID":53955,"DIRECTION":"BI","MASTER_ID":53952,"compounds":"4-aminobutanoyl-[BtrI ACP] + ATP + L-glutamate <=> 4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + ADP + H(+) + phosphate","pmd":79.966}
{"X":5804,"KEGG":"R08907","RHEA_ID":53959,"DIRECTION":"BI","MASTER_ID":53956,"compounds":"gamma-L-glutamyl-[BtrI ACP] + H(+) <=> 4-aminobutanoyl-[BtrI ACP] + CO2"}
{"X":5805,"KEGG":"R08908","RHEA_ID":53963,"DIRECTION":"BI","MASTER_ID":53960,"compounds":"4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + FMNH2 + O2 <=> 4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + FMN + H(+) + H2O","pmd":2.016}
{"X":5806,"KEGG":"R08909","RHEA_ID":53967,"DIRECTION":"BI","MASTER_ID":53964,"compounds":"4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + ribostamycin <=> gamma-L-glutamyl-butirosin B + H(+) + holo-[BtrI ACP]","pmd":230.09}
{"X":5807,"KEGG":"R08910","RHEA_ID":33998,"DIRECTION":"BI","MASTER_ID":33995,"compounds":"gamma-L-glutamyl-butirosin B <=> 5-oxo-L-proline + butirosin B","pmd":129.043}
{"X":5808,"KEGG":"R08912","RHEA_ID":26034,"DIRECTION":"BI","MASTER_ID":26031,"compounds":"2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3,3'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]","pmd":204.006}
{"X":5809,"KEGG":"R08913","RHEA_ID":26038,"DIRECTION":"BI","MASTER_ID":26035,"compounds":"2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3,8'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]","pmd":204.006}
{"X":5810,"KEGG":"R08914","RHEA_ID":24771,"DIRECTION":"BI","MASTER_ID":24768,"compounds":"7(1)-hydroxychlorophyllide a + NAD(+) <=> chlorophyllide b + H(+) + NADH","pmd":2.016}
{"X":5811,"KEGG":"R08914","RHEA_ID":24771,"DIRECTION":"BI","MASTER_ID":24768,"compounds":"7(1)-hydroxychlorophyllide a + NAD(+) <=> chlorophyllide b + H(+) + NADH","pmd":35.9}
{"X":5812,"KEGG":"R08915","RHEA_ID":24775,"DIRECTION":"BI","MASTER_ID":24772,"compounds":"7(1)-hydroxychlorophyllide a + NADP(+) <=> chlorophyllide b + H(+) + NADPH","pmd":2.016}
{"X":5813,"KEGG":"R08915","RHEA_ID":24775,"DIRECTION":"BI","MASTER_ID":24772,"compounds":"7(1)-hydroxychlorophyllide a + NADP(+) <=> chlorophyllide b + H(+) + NADPH","pmd":115.866}
{"X":5814,"KEGG":"R08916","RHEA_ID":25366,"DIRECTION":"BI","MASTER_ID":25363,"compounds":"3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NAD(+) <=> H(+) + momilactone A + NADH","pmd":2.016}
{"X":5815,"KEGG":"R08916","RHEA_ID":25366,"DIRECTION":"BI","MASTER_ID":25363,"compounds":"3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NAD(+) <=> H(+) + momilactone A + NADH","pmd":349.929}
{"X":5816,"KEGG":"R08917","RHEA_ID":25370,"DIRECTION":"BI","MASTER_ID":25367,"compounds":"3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NADP(+) <=> H(+) + momilactone A + NADPH","pmd":2.016}
{"X":5817,"KEGG":"R08917","RHEA_ID":25370,"DIRECTION":"BI","MASTER_ID":25367,"compounds":"3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NADP(+) <=> H(+) + momilactone A + NADPH","pmd":429.895}
{"X":5818,"KEGG":"R08920","RHEA_ID":25883,"DIRECTION":"BI","MASTER_ID":25880,"compounds":"2 L-dopa + O2 <=> 2 3-(3,4-dihydroxyphenyl)pyruvate + 2 NH4(+)","pmd":1.032}
{"X":5819,"KEGG":"R08921","RHEA_ID":48143,"DIRECTION":"BI","MASTER_ID":48140,"compounds":"2 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 oxidized [2Fe-2S]-[ferredoxin] + red chlorophyll catabolite","pmd":34.005}
{"X":5820,"KEGG":"R08921","RHEA_ID":24759,"DIRECTION":"BI","MASTER_ID":24756,"compounds":"H(+) + NADPH + O2 + pheophorbide a <=> NADP(+) + red chlorophyll catabolite","pmd":34.005}
{"X":5821,"KEGG":"R08922","RHEA_ID":11735,"DIRECTION":"BI","MASTER_ID":11732,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + sophoraflavanone B <=> H(+) + H2O + leachianone G + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":5822,"KEGG":"R08923","RHEA_ID":25661,"DIRECTION":"BI","MASTER_ID":25658,"compounds":"(R)-pulegone + O2 + reduced [NADPH--hemoprotein reductase] <=> (R)-menthofuran + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]","pmd":2.016}
{"X":5823,"KEGG":"R08925","RHEA_ID":32434,"DIRECTION":"BI","MASTER_ID":32431,"compounds":"(1R,4S)-menthone + H(+) + NADPH + O2 <=> (4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)","pmd":574.96}
{"X":5824,"KEGG":"R08925","RHEA_ID":32434,"DIRECTION":"BI","MASTER_ID":32431,"compounds":"(1R,4S)-menthone + H(+) + NADPH + O2 <=> (4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)","pmd":15.995}
{"X":5825,"KEGG":"R08931","RHEA_ID":49147,"DIRECTION":"BI","MASTER_ID":49144,"metacyc":"RXN-12407","compounds":"2-oxoglutarate + dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose <=> dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + L-glutamate","pmd":1.032}
{"X":5826,"KEGG":"R08932","RHEA_ID":49151,"DIRECTION":"BI","MASTER_ID":49148,"compounds":"dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + 2 S-adenosyl-L-methionine <=> dTDP-alpha-D-forosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5827,"KEGG":"R08932","RHEA_ID":49151,"DIRECTION":"BI","MASTER_ID":49148,"compounds":"dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + 2 S-adenosyl-L-methionine <=> dTDP-alpha-D-forosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine","pmd":28.031}
{"X":5828,"KEGG":"R08936","RHEA_ID":23031,"DIRECTION":"BI","MASTER_ID":23028,"compounds":"malonyl-[ACP] + N(6)-biotinyl-L-lysyl-[protein] <=> acetyl-[ACP] + N(6)-carboxybiotinyl-L-lysyl-[protein]"}
{"X":5829,"KEGG":"R08938","RHEA_ID":12600,"DIRECTION":"BI","MASTER_ID":12597,"metacyc":"RXN-9382","compounds":"acetyl-CoA + phosphinothricin <=> CoA + H(+) + N-acetylphosphinothricin","pmd":42.011}
{"X":5830,"KEGG":"R08940","RHEA_ID":10099,"DIRECTION":"BI","MASTER_ID":10096,"compounds":"a fatty acyl-[ACP] + S-adenosyl-L-methionine <=> an N-acyl-L-homoserine lactone + H(+) + holo-[ACP] + S-methyl-5'-thioadenosine","pmd":101.048}
{"X":5831,"KEGG":"R08944","RHEA_ID":17652,"DIRECTION":"BI","MASTER_ID":17649,"compounds":"acetyl-[ACP] + malonate <=> acetate + malonyl-[ACP]"}
{"X":5832,"KEGG":"R08947","RHEA_ID":26042,"DIRECTION":"BI","MASTER_ID":26039,"compounds":"beta-D-fructose 6-phosphate + GDP-alpha-D-mannose <=> beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + GDP + H(+)","pmd":162.053}
{"X":5833,"KEGG":"R08948","RHEA_ID":14012,"DIRECTION":"BI","MASTER_ID":14009,"compounds":"2 dimethylallyl diphosphate <=> (R,R)-chrysanthemyl diphosphate + diphosphate","pmd":68.063}
{"X":5834,"KEGG":"R08950","RHEA_ID":21679,"DIRECTION":"BI","MASTER_ID":21676,"compounds":"2 dimethylallyl diphosphate <=> (R)-lavandulyl diphosphate + diphosphate","pmd":68.063}
{"X":5835,"KEGG":"R08951","RHEA_ID":15436,"DIRECTION":"BI","MASTER_ID":15433,"compounds":"(S)-naringenin + dimethylallyl diphosphate <=> diphosphate + sophoraflavanone B","pmd":68.063}
{"X":5836,"KEGG":"R08951","RHEA_ID":15436,"DIRECTION":"BI","MASTER_ID":15433,"compounds":"(S)-naringenin + dimethylallyl diphosphate <=> diphosphate + sophoraflavanone B","pmd":94.125}
{"X":5837,"KEGG":"R08952","RHEA_ID":10855,"DIRECTION":"BI","MASTER_ID":10852,"compounds":"dimethylallyl diphosphate + leachianone G <=> diphosphate + sophoraflavanone G","pmd":68.063}
{"X":5838,"KEGG":"R08952","RHEA_ID":10855,"DIRECTION":"BI","MASTER_ID":10852,"compounds":"dimethylallyl diphosphate + leachianone G <=> diphosphate + sophoraflavanone G","pmd":178.183}
{"X":5839,"KEGG":"R08956","RHEA_ID":25515,"DIRECTION":"BI","MASTER_ID":25512,"metacyc":"RXN-9028","compounds":"(2S)-2-amino-4-deoxychorismate + L-glutamate <=> chorismate + L-glutamine","pmd":0.984}
{"X":5840,"KEGG":"R08962","RHEA_ID":25431,"DIRECTION":"BI","MASTER_ID":25428,"metacyc":"RXN-9297","compounds":"ATP + N-acetyl-D-hexosamine <=> ADP + H(+) + N-acetyl-alpha-D-hexosamine 1-phosphate","pmd":79.966}
{"X":5841,"KEGG":"R08964","RHEA_ID":10279,"DIRECTION":"BI","MASTER_ID":10276,"compounds":"5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) <=> 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP","pmd":79.966}
{"X":5842,"KEGG":"R08966","RHEA_ID":25693,"DIRECTION":"BI","MASTER_ID":25690,"compounds":"2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate + CTP + H(+) <=> CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol + diphosphate"}
{"X":5843,"KEGG":"R08967","RHEA_ID":12620,"DIRECTION":"BI","MASTER_ID":12617,"metacyc":"2.7.1.157-RXN","compounds":"ATP + N-acetyl-alpha-D-galactosamine <=> ADP + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate","pmd":79.966}
{"X":5844,"KEGG":"R08968","RHEA_ID":53727,"DIRECTION":"BI","MASTER_ID":53724,"compounds":"ATP + N-acetyl-D-glucosamine <=> ADP + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate","pmd":79.966}
{"X":5845,"KEGG":"R08969","RHEA_ID":18768,"DIRECTION":"BI","MASTER_ID":18765,"metacyc":"2.7.8.27-RXN","compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine <=> a 1,2-diacyl-sn-glycerol + sphingomyelin"}
{"X":5846,"KEGG":"R08970","RHEA_ID":22579,"DIRECTION":"BI","MASTER_ID":22576,"compounds":"an N-acyl-L-homoserine lactone + H2O <=> an N-acyl-L-homoserine + H(+)"}
{"X":5847,"KEGG":"R08972","RHEA_ID":32118,"DIRECTION":"BI","MASTER_ID":32115,"compounds":"2-oxoglutarate + DIBOA beta-D-glucoside + O2 <=> CO2 + succinate + TRIBOA beta-D-glucoside","pmd":15.995}
{"X":5848,"KEGG":"R08972","RHEA_ID":32118,"DIRECTION":"BI","MASTER_ID":32115,"compounds":"2-oxoglutarate + DIBOA beta-D-glucoside + O2 <=> CO2 + succinate + TRIBOA beta-D-glucoside","pmd":27.995}
{"X":5849,"KEGG":"R08973","RHEA_ID":32102,"DIRECTION":"BI","MASTER_ID":32099,"compounds":"S-adenosyl-L-methionine + TRIBOA beta-D-glucoside <=> DIMBOA beta-D-glucoside + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5850,"KEGG":"R08974","RHEA_ID":32486,"DIRECTION":"BI","MASTER_ID":32483,"compounds":"H(+) + H2O + pheophorbide a <=> CO2 + methanol + pyropheophorbide a","pmd":58.005}
{"X":5851,"KEGG":"R08975","RHEA_ID":24779,"DIRECTION":"BI","MASTER_ID":24776,"compounds":"H2O + pheophorbide a <=> C-13(2)-carboxypyropheophorbide a + methanol","pmd":14.016}
{"X":5852,"KEGG":"R08976","RHEA_ID":24783,"DIRECTION":"BI","MASTER_ID":24780,"compounds":"C-13(2)-carboxypyropheophorbide a + H(+) <=> CO2 + pyropheophorbide a","pmd":43.99}
{"X":5853,"KEGG":"R08981","RHEA_ID":25677,"DIRECTION":"BI","MASTER_ID":25674,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate"}
{"X":5854,"KEGG":"R08982","RHEA_ID":26022,"DIRECTION":"BI","MASTER_ID":26019,"compounds":"beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + H2O <=> beta-D-fructofuranosyl alpha-D-mannopyranoside + phosphate","pmd":79.966}
{"X":5855,"KEGG":"R08991","RHEA_ID":24905,"DIRECTION":"BI","MASTER_ID":24902,"compounds":"cyclic di-3',5'-guanylate + H2O <=> 5'-phosphoguanylyl(3'->5')guanosine + H(+)","pmd":18.01}
{"X":5856,"KEGG":"R08993","RHEA_ID":26240,"DIRECTION":"BI","MASTER_ID":26237,"compounds":"all-trans-geranylgeranyl diphosphate + H2O <=> (2E,6E,10E)-geranylgeraniol + diphosphate","pmd":159.933}
{"X":5857,"KEGG":"R08996","RHEA_ID":51871,"DIRECTION":"BI","MASTER_ID":51868,"compounds":"dimethylallyl diphosphate + umbelliferone <=> demethylsuberosin + diphosphate","pmd":68.063}
{"X":5858,"KEGG":"R08996","RHEA_ID":51871,"DIRECTION":"BI","MASTER_ID":51868,"compounds":"dimethylallyl diphosphate + umbelliferone <=> demethylsuberosin + diphosphate","pmd":15.911}
{"X":5859,"KEGG":"R08997","RHEA_ID":32474,"DIRECTION":"BI","MASTER_ID":32471,"compounds":"demethylsuberosin + O2 + reduced [NADPH--hemoprotein reductase] <=> (7S)-marmesin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":5860,"KEGG":"R09002","RHEA_ID":27484,"DIRECTION":"BI","MASTER_ID":27481,"compounds":"(S)-columbianetin + O2 + reduced [NADPH--hemoprotein reductase] <=> acetone + angelicin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]","pmd":60.058}
{"X":5861,"KEGG":"R09030","RHEA_ID":28433,"DIRECTION":"BI","MASTER_ID":28430,"ecocyc":"RXN0-303","metacyc":"RXN0-303","compounds":"D-allose 6-phosphate <=> D-allulose 6-phosphate","pmd":0}
{"X":5862,"KEGG":"R09031","RHEA_ID":28429,"DIRECTION":"BI","MASTER_ID":28426,"compounds":"D-allulose 6-phosphate <=> keto-D-fructose 6-phosphate","pmd":0}
{"X":5863,"KEGG":"R09032","RHEA_ID":24755,"DIRECTION":"BI","MASTER_ID":24752,"compounds":"2 oxidized [2Fe-2S]-[ferredoxin] + primary fluorescent chlorophyll catabolite <=> 3 H(+) + red chlorophyll catabolite + 2 reduced [2Fe-2S]-[ferredoxin]","pmd":2.016}
{"X":5864,"KEGG":"R09033","RHEA_ID":52795,"DIRECTION":"BI","MASTER_ID":52792,"compounds":"chlorophyllide a + 2 H(+) <=> Mg(2+) + pheophorbide a","pmd":21.969}
{"X":5865,"KEGG":"R09040","RHEA_ID":27857,"DIRECTION":"BI","MASTER_ID":27854,"compounds":"(2E)-geranyl diphosphate + 4-hydroxybenzoate <=> 3-geranyl-4-hydroxybenzoate + diphosphate","pmd":136.125}
{"X":5866,"KEGG":"R09040","RHEA_ID":27857,"DIRECTION":"BI","MASTER_ID":27854,"compounds":"(2E)-geranyl diphosphate + 4-hydroxybenzoate <=> 3-geranyl-4-hydroxybenzoate + diphosphate","pmd":39.911}
{"X":5867,"KEGG":"R09053","RHEA_ID":37054,"DIRECTION":"BI","MASTER_ID":37051,"compounds":"3-deacetyl-3-vinylbacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate <=> ATP + chlorophyllide a + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]","pmd":2.016}
{"X":5868,"KEGG":"R09053","RHEA_ID":37054,"DIRECTION":"BI","MASTER_ID":37051,"compounds":"3-deacetyl-3-vinylbacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate <=> ATP + chlorophyllide a + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]","pmd":79.966}
{"X":5869,"KEGG":"R09054","RHEA_ID":48775,"DIRECTION":"BI","MASTER_ID":48772,"compounds":"3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a <=> 3-deacetyl-3-vinylbacteriochlorophyllide a + H2O","pmd":18.011}
{"X":5870,"KEGG":"R09055","RHEA_ID":19736,"DIRECTION":"BI","MASTER_ID":19733,"compounds":"3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + NAD(+) <=> bacteriochlorophyllide a + H(+) + NADH","pmd":31.868}
{"X":5871,"KEGG":"R09055","RHEA_ID":19736,"DIRECTION":"BI","MASTER_ID":19733,"compounds":"3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + NAD(+) <=> bacteriochlorophyllide a + H(+) + NADH","pmd":2.016}
{"X":5872,"KEGG":"R09059","RHEA_ID":15072,"DIRECTION":"BI","MASTER_ID":15069,"compounds":"3-devinyl-3-(1-hydroxyethyl)chlorophyllide a <=> chlorophyllide a + H2O","pmd":18.01}
{"X":5873,"KEGG":"R09060","RHEA_ID":48951,"DIRECTION":"BI","MASTER_ID":48948,"compounds":"3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate <=> 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]","pmd":2.016}
{"X":5874,"KEGG":"R09060","RHEA_ID":48951,"DIRECTION":"BI","MASTER_ID":48948,"compounds":"3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate <=> 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]","pmd":79.966}
{"X":5875,"KEGG":"R09061","RHEA_ID":49187,"DIRECTION":"BI","MASTER_ID":49184,"compounds":"chlorophyllide a + H(+) + H2O <=> 8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + CO2 + methanol","pmd":58.006}
{"X":5876,"KEGG":"R09063","RHEA_ID":49183,"DIRECTION":"BI","MASTER_ID":49180,"metacyc":"RXN-17449","compounds":"a bacteriochlorophyllide d + S-adenosyl-L-methionine <=> a bacteriochlorophyllide c + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":5877,"KEGG":"R09069","RHEA_ID":43491,"DIRECTION":"BI","MASTER_ID":43488,"compounds":"7(1)-hydroxychlorophyll a + NAD(+) <=> chlorophyll b + H(+) + NADH","pmd":2.016}
{"X":5878,"KEGG":"R09069","RHEA_ID":43491,"DIRECTION":"BI","MASTER_ID":43488,"compounds":"7(1)-hydroxychlorophyll a + NAD(+) <=> chlorophyll b + H(+) + NADH","pmd":242.398}
{"X":5879,"KEGG":"R09070","RHEA_ID":43495,"DIRECTION":"BI","MASTER_ID":43492,"compounds":"7(1)-hydroxychlorophyll a + NADP(+) <=> chlorophyll b + H(+) + NADPH","pmd":162.431}
{"X":5880,"KEGG":"R09070","RHEA_ID":43495,"DIRECTION":"BI","MASTER_ID":43492,"compounds":"7(1)-hydroxychlorophyll a + NADP(+) <=> chlorophyll b + H(+) + NADPH","pmd":2.016}
{"X":5881,"KEGG":"R09071","RHEA_ID":53547,"DIRECTION":"BI","MASTER_ID":53544,"compounds":"chlorophyll a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 7(1)-hydroxychlorophyll a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]","pmd":15.995}
{"X":5882,"KEGG":"R09074","RHEA_ID":25815,"DIRECTION":"BI","MASTER_ID":25812,"compounds":"H2O + N(1)-acetylspermidine + O2 <=> 3-acetamidopropanal + H2O2 + putrescine","pmd":72.105}
{"X":5883,"KEGG":"R09075","RHEA_ID":25975,"DIRECTION":"BI","MASTER_ID":25972,"compounds":"H2O + N(8)-acetylspermidine + O2 <=> 4-acetamidobutanal + H2O2 + propane-1,3-diamine","pmd":58.089}
{"X":5884,"KEGG":"R09076","RHEA_ID":25807,"DIRECTION":"BI","MASTER_ID":25804,"compounds":"H2O + O2 + spermine <=> 3-aminopropanal + H2O2 + spermidine","pmd":57.058}
{"X":5885,"KEGG":"R09077","RHEA_ID":25811,"DIRECTION":"BI","MASTER_ID":25808,"compounds":"H2O + O2 + spermidine <=> 3-aminopropanal + H2O2 + putrescine"}
{"X":5886,"KEGG":"R09078","RHEA_ID":27289,"DIRECTION":"BI","MASTER_ID":27286,"compounds":"(S)-acetoin + NAD(+) <=> diacetyl + H(+) + NADH"}
{"X":5887,"KEGG":"R09079","RHEA_ID":34114,"DIRECTION":"BI","MASTER_ID":34111,"compounds":"carboxyspermidine + H2O + NADP(+) <=> H(+) + L-aspartate 4-semialdehyde + NADPH + putrescine","pmd":555.943}
{"X":5888,"KEGG":"R09079","RHEA_ID":34114,"DIRECTION":"BI","MASTER_ID":34111,"compounds":"carboxyspermidine + H2O + NADP(+) <=> H(+) + L-aspartate 4-semialdehyde + NADPH + putrescine","pmd":72.105}
{"X":5889,"KEGG":"R09080","RHEA_ID":34118,"DIRECTION":"BI","MASTER_ID":34115,"compounds":"carboxynorspermidine + H2O + NADP(+) <=> H(+) + L-aspartate 4-semialdehyde + NADPH + propane-1,3-diamine","pmd":58.09}
{"X":5890,"KEGG":"R09080","RHEA_ID":34118,"DIRECTION":"BI","MASTER_ID":34115,"compounds":"carboxynorspermidine + H2O + NADP(+) <=> H(+) + L-aspartate 4-semialdehyde + NADPH + propane-1,3-diamine","pmd":569.959}
{"X":5891,"KEGG":"R09081","RHEA_ID":34102,"DIRECTION":"BI","MASTER_ID":34099,"compounds":"carboxynorspermidine + H(+) <=> CO2 + norspermidine","pmd":43.99}
{"X":5892,"KEGG":"R09081","RHEA_ID":34098,"DIRECTION":"BI","MASTER_ID":34095,"compounds":"carboxyspermidine + H(+) <=> CO2 + spermidine","pmd":43.99}
{"X":5893,"KEGG":"R09083","RHEA_ID":27348,"DIRECTION":"BI","MASTER_ID":27345,"compounds":"FMNH2 + O2 <=> 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialurate + H(+)","pmd":258.112}
{"X":5894,"KEGG":"R09095","RHEA_ID":24439,"DIRECTION":"BI","MASTER_ID":24436,"compounds":"H2 + methanophenazine <=> dihydromethanophenazine","pmd":2.016}
{"X":5895,"KEGG":"R09097","RHEA_ID":36030,"DIRECTION":"BI","MASTER_ID":36027,"metacyc":"RXN-12736","compounds":"CoA + NAD(+) + propanal <=> H(+) + NADH + propanoyl-CoA","pmd":56.026}
{"X":5896,"KEGG":"R09097","RHEA_ID":36030,"DIRECTION":"BI","MASTER_ID":36027,"metacyc":"RXN-12736","compounds":"CoA + NAD(+) + propanal <=> H(+) + NADH + propanoyl-CoA","pmd":159.024}
{"X":5897,"KEGG":"R09106","RHEA_ID":26473,"DIRECTION":"BI","MASTER_ID":26470,"metacyc":"RXN-10749","compounds":"(E)-feruloyl-CoA + 16-hydroxyhexadecanoate <=> 16-feruloyloxyhexadecanoate + CoA","pmd":176.047}
{"X":5898,"KEGG":"R09107","RHEA_ID":61095,"DIRECTION":"BI","MASTER_ID":61092,"compounds":"H2O + N(2)-acetyl-L-citrulline <=> acetate + L-citrulline","pmd":42.011}
{"X":5899,"KEGG":"R09111","RHEA_ID":26131,"DIRECTION":"BI","MASTER_ID":26128,"compounds":"(+)-copalyl diphosphate <=> diphosphate + isopimara-7,15-diene","pmd":177.943}
{"X":5900,"KEGG":"R09115","RHEA_ID":25555,"DIRECTION":"BI","MASTER_ID":25552,"compounds":"9alpha-copalyl diphosphate <=> diphosphate + stemar-13-ene","pmd":177.943}
{"X":5901,"KEGG":"R09116","RHEA_ID":25559,"DIRECTION":"BI","MASTER_ID":25556,"compounds":"9alpha-copalyl diphosphate <=> diphosphate + stemod-13(17)-ene","pmd":177.943}
{"X":5902,"KEGG":"R09117","RHEA_ID":25563,"DIRECTION":"BI","MASTER_ID":25560,"compounds":"9alpha-copalyl diphosphate <=> 9beta-pimara-7,15-diene + diphosphate","pmd":177.943}
{"X":5903,"KEGG":"R09119","RHEA_ID":25535,"DIRECTION":"BI","MASTER_ID":25532,"compounds":"ent-copalyl diphosphate <=> diphosphate + ent-cassa-12,15-diene","pmd":177.943}
{"X":5904,"KEGG":"R09120","RHEA_ID":25539,"DIRECTION":"BI","MASTER_ID":25536,"compounds":"ent-copalyl diphosphate <=> diphosphate + ent-sandaracopimara-8(14),15-diene","pmd":177.943}
{"X":5905,"KEGG":"R09121","RHEA_ID":25543,"DIRECTION":"BI","MASTER_ID":25540,"compounds":"ent-copalyl diphosphate <=> diphosphate + ent-pimara-8(14),15-diene","pmd":177.943}
{"X":5906,"KEGG":"R09122","RHEA_ID":26236,"DIRECTION":"BI","MASTER_ID":26233,"compounds":"(2E,6E,10E)-geranylgeraniol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + plaunotol","pmd":15.995}
{"X":5907,"KEGG":"R09123","RHEA_ID":26248,"DIRECTION":"BI","MASTER_ID":26245,"compounds":"geranylgeranyl diphosphate <=> diphosphate + fusicocca-2,10(14)-diene","pmd":177.943}
{"X":5908,"KEGG":"R09125","RHEA_ID":27525,"DIRECTION":"BI","MASTER_ID":27522,"compounds":"2,5-dihydroxypyridine + O2 <=> H(+) + N-formylmaleamate","pmd":31.99}
{"X":5909,"KEGG":"R09126","RHEA_ID":30846,"DIRECTION":"BI","MASTER_ID":30843,"compounds":"H2O + N-formylmaleamate <=> formate + H(+) + maleamate","pmd":27.995}
{"X":5910,"KEGG":"R09129","RHEA_ID":28505,"DIRECTION":"BI","MASTER_ID":28502,"compounds":"NAD(+) + S-(hydroxymethyl)mycothiol <=> H(+) + NADH + S-formylmycothiol","pmd":2.016}
{"X":5911,"KEGG":"R09129","RHEA_ID":28505,"DIRECTION":"BI","MASTER_ID":28502,"compounds":"NAD(+) + S-(hydroxymethyl)mycothiol <=> H(+) + NADH + S-formylmycothiol","pmd":149.97}
{"X":5912,"KEGG":"R09140","RHEA_ID":26118,"DIRECTION":"BI","MASTER_ID":26115,"compounds":"(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + epi-cedrol","pmd":159.933}
{"X":5913,"KEGG":"R09186","RHEA_ID":35810,"DIRECTION":"BI","MASTER_ID":35807,"compounds":"2-dehydro-3-deoxy-D-arabinonate <=> 2,5-dioxopentanoate + H2O","pmd":18.011}
{"X":5914,"KEGG":"R09192","RHEA_ID":50395,"DIRECTION":"BI","MASTER_ID":50392,"compounds":"H(+) + oxidized coenzyme F420-(gamma-Glu)(n) + oxytetracycline <=> 5a,11a-dehydrooxytetracycline + reduced coenzyme F420-(gamma-Glu)(n)","pmd":2.016}
{"X":5915,"KEGG":"R09233","RHEA_ID":46763,"DIRECTION":"BI","MASTER_ID":46760,"compounds":"2,4-dinitrotoluene + NADH + O2 <=> 4-methyl-5-nitrocatechol + NAD(+) + nitrite","pmd":12.995}
{"X":5916,"KEGG":"R09233","RHEA_ID":46763,"DIRECTION":"BI","MASTER_ID":46760,"compounds":"2,4-dinitrotoluene + NADH + O2 <=> 4-methyl-5-nitrocatechol + NAD(+) + nitrite","pmd":496.087}
{"X":5917,"KEGG":"R09234","RHEA_ID":48015,"DIRECTION":"BI","MASTER_ID":48012,"compounds":"4-methyl-5-nitrocatechol + NADPH + O2 <=> 2-hydroxy-5-methylquinone + H(+) + H2O + NADP(+) + nitrite","pmd":607.059}
{"X":5918,"KEGG":"R09234","RHEA_ID":48015,"DIRECTION":"BI","MASTER_ID":48012,"compounds":"4-methyl-5-nitrocatechol + NADPH + O2 <=> 2-hydroxy-5-methylquinone + H(+) + H2O + NADP(+) + nitrite","pmd":31.006}
{"X":5919,"KEGG":"R09236","RHEA_ID":48019,"DIRECTION":"BI","MASTER_ID":48016,"compounds":"4-methyl-5-nitrocatechol + NADH + O2 <=> 2-hydroxy-5-methylquinone + H(+) + H2O + NAD(+) + nitrite","pmd":525.078}
{"X":5920,"KEGG":"R09236","RHEA_ID":48019,"DIRECTION":"BI","MASTER_ID":48016,"compounds":"4-methyl-5-nitrocatechol + NADH + O2 <=> 2-hydroxy-5-methylquinone + H(+) + H2O + NAD(+) + nitrite","pmd":2.016}
{"X":5921,"KEGG":"R09244","RHEA_ID":47099,"DIRECTION":"BI","MASTER_ID":47096,"compounds":"(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate <=> (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate + 7 diphosphate","pmd":612.563}
{"X":5922,"KEGG":"R09244","RHEA_ID":47099,"DIRECTION":"BI","MASTER_ID":47096,"compounds":"(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate <=> (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate + 7 diphosphate","pmd":476.438}
{"X":5923,"KEGG":"R09245","RHEA_ID":27562,"DIRECTION":"BI","MASTER_ID":27559,"metacyc":"TRANS-PENTAPRENYLTRANSFERASE-RXN","compounds":"(2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate <=> all-trans-hexaprenyl diphosphate + 3 diphosphate","pmd":340.313}
{"X":5924,"KEGG":"R09245","RHEA_ID":27562,"DIRECTION":"BI","MASTER_ID":27559,"metacyc":"TRANS-PENTAPRENYLTRANSFERASE-RXN","compounds":"(2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate <=> all-trans-hexaprenyl diphosphate + 3 diphosphate","pmd":204.188}
{"X":5925,"KEGG":"R09246","RHEA_ID":27558,"DIRECTION":"BI","MASTER_ID":27555,"metacyc":"RXN-11485","compounds":"all-trans-geranylgeranyl diphosphate + 2 isopentenyl diphosphate <=> all-trans-hexaprenyl diphosphate + 2 diphosphate","pmd":136.125}
{"X":5926,"KEGG":"R09246","RHEA_ID":27558,"DIRECTION":"BI","MASTER_ID":27555,"metacyc":"RXN-11485","compounds":"all-trans-geranylgeranyl diphosphate + 2 isopentenyl diphosphate <=> all-trans-hexaprenyl diphosphate + 2 diphosphate","pmd":340.313}
{"X":5927,"KEGG":"R09247","RHEA_ID":27797,"DIRECTION":"BI","MASTER_ID":27794,"metacyc":"TRANS-HEXAPRENYLTRANSTRANSFERASE-RXN","compounds":"(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate <=> all-trans-heptaprenyl diphosphate + 4 diphosphate","pmd":272.25}
{"X":5928,"KEGG":"R09247","RHEA_ID":27797,"DIRECTION":"BI","MASTER_ID":27794,"metacyc":"TRANS-HEXAPRENYLTRANSTRANSFERASE-RXN","compounds":"(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate <=> all-trans-heptaprenyl diphosphate + 4 diphosphate","pmd":408.376}
{"X":5929,"KEGG":"R09248","RHEA_ID":27801,"DIRECTION":"BI","MASTER_ID":27798,"compounds":"(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate <=> all-trans-octaprenyl diphosphate + 5 diphosphate","pmd":476.438}
{"X":5930,"KEGG":"R09248","RHEA_ID":27801,"DIRECTION":"BI","MASTER_ID":27798,"compounds":"(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate <=> all-trans-octaprenyl diphosphate + 5 diphosphate","pmd":340.313}
{"X":5931,"KEGG":"R09249","RHEA_ID":27805,"DIRECTION":"BI","MASTER_ID":27802,"compounds":"(2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate <=> all-trans-decaprenyl diphosphate + 7 diphosphate","pmd":612.563}
{"X":5932,"KEGG":"R09249","RHEA_ID":27805,"DIRECTION":"BI","MASTER_ID":27802,"compounds":"(2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate <=> all-trans-decaprenyl diphosphate + 7 diphosphate","pmd":476.438}
{"X":5933,"KEGG":"R09250","RHEA_ID":27566,"DIRECTION":"BI","MASTER_ID":27563,"compounds":"(2E)-geranyl diphosphate + 7 isopentenyl diphosphate <=> all-trans-nonaprenyl diphosphate + 7 diphosphate","pmd":476.438}
{"X":5934,"KEGG":"R09250","RHEA_ID":27566,"DIRECTION":"BI","MASTER_ID":27563,"compounds":"(2E)-geranyl diphosphate + 7 isopentenyl diphosphate <=> all-trans-nonaprenyl diphosphate + 7 diphosphate","pmd":544.501}
{"X":5935,"KEGG":"R09251","RHEA_ID":27597,"DIRECTION":"BI","MASTER_ID":27594,"compounds":"all-trans-geranylgeranyl diphosphate + 5 isopentenyl diphosphate <=> all-trans-nonaprenyl diphosphate + 5 diphosphate","pmd":340.313}
{"X":5936,"KEGG":"R09251","RHEA_ID":27597,"DIRECTION":"BI","MASTER_ID":27594,"compounds":"all-trans-geranylgeranyl diphosphate + 5 isopentenyl diphosphate <=> all-trans-nonaprenyl diphosphate + 5 diphosphate","pmd":544.501}
{"X":5937,"KEGG":"R09252","RHEA_ID":12996,"DIRECTION":"BI","MASTER_ID":12993,"metacyc":"R265-RXN","compounds":"cyclohex-1-ene-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> cyclohexa-1,5-diene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein]","pmd":2.016}
{"X":5938,"KEGG":"R09270","RHEA_ID":59843,"DIRECTION":"BI","MASTER_ID":59840,"compounds":"(6S)-5,6,7,8-tetrahydrofolate + syringate <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-O-methylgallate","pmd":14.016}
{"X":5939,"KEGG":"R09271","RHEA_ID":52283,"DIRECTION":"BI","MASTER_ID":52280,"compounds":"(6S)-5,6,7,8-tetrahydrofolate + 3-O-methylgallate <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4,5-trihydroxybenzoate","pmd":14.016}
{"X":5940,"KEGG":"R09279","RHEA_ID":23131,"DIRECTION":"BI","MASTER_ID":23128,"compounds":"4-hydroxybutanoate + ATP + CoA <=> 4-hydroxybutanoyl-CoA + AMP + diphosphate","pmd":243.016}
{"X":5941,"KEGG":"R09279","RHEA_ID":23131,"DIRECTION":"BI","MASTER_ID":23128,"compounds":"4-hydroxybutanoate + ATP + CoA <=> 4-hydroxybutanoyl-CoA + AMP + diphosphate","pmd":159.933}
{"X":5942,"KEGG":"R09279","RHEA_ID":23131,"DIRECTION":"BI","MASTER_ID":23128,"compounds":"4-hydroxybutanoate + ATP + CoA <=> 4-hydroxybutanoyl-CoA + AMP + diphosphate","pmd":86.037}
{"X":5943,"KEGG":"R09280","RHEA_ID":26453,"DIRECTION":"BI","MASTER_ID":26450,"compounds":"CoA + NADP(+) + succinate semialdehyde <=> H(+) + NADPH + succinyl-CoA","pmd":100.016}
{"X":5944,"KEGG":"R09280","RHEA_ID":26453,"DIRECTION":"BI","MASTER_ID":26450,"compounds":"CoA + NADP(+) + succinate semialdehyde <=> H(+) + NADPH + succinyl-CoA","pmd":22.024}
{"X":5945,"KEGG":"R09281","RHEA_ID":26384,"DIRECTION":"BI","MASTER_ID":26381,"compounds":"4-hydroxybutanoate + NADP(+) <=> H(+) + NADPH + succinate semialdehyde","pmd":2.016}
{"X":5946,"KEGG":"R09281","RHEA_ID":26384,"DIRECTION":"BI","MASTER_ID":26381,"compounds":"4-hydroxybutanoate + NADP(+) <=> H(+) + NADPH + succinate semialdehyde","pmd":642.052}
{"X":5947,"KEGG":"R09282","RHEA_ID":38274,"DIRECTION":"BI","MASTER_ID":38271,"compounds":"(3S)-citramalyl-CoA <=> 3-methylfumaryl-CoA + H2O","pmd":18.01}
{"X":5948,"KEGG":"R09283","RHEA_ID":38270,"DIRECTION":"BI","MASTER_ID":38267,"metacyc":"RXN-13230","compounds":"2-methylfumaryl-CoA <=> 3-methylfumaryl-CoA","pmd":0}
{"X":5949,"KEGG":"R09286","RHEA_ID":26537,"DIRECTION":"BI","MASTER_ID":26534,"compounds":"3-hydroxypropanoate + ATP + CoA <=> 3-hydroxypropanoyl-CoA + AMP + diphosphate","pmd":159.933}
{"X":5950,"KEGG":"R09286","RHEA_ID":26537,"DIRECTION":"BI","MASTER_ID":26534,"compounds":"3-hydroxypropanoate + ATP + CoA <=> 3-hydroxypropanoyl-CoA + AMP + diphosphate","pmd":72.021}
{"X":5951,"KEGG":"R09292","RHEA_ID":45579,"DIRECTION":"BI","MASTER_ID":45576,"compounds":"(2R)-ethylmalonyl-CoA <=> (2S)-methylsuccinyl-CoA","pmd":0}
{"X":5952,"KEGG":"R09293","RHEA_ID":45031,"DIRECTION":"BI","MASTER_ID":45028,"compounds":"(2S)-methylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> 2-methylfumaryl-CoA + reduced [electron-transfer flavoprotein]","pmd":2.016}
{"X":5953,"KEGG":"R09327","RHEA_ID":45059,"DIRECTION":"BI","MASTER_ID":45056,"compounds":"deoxynogalonate + O2 <=> H(+) + H2O + nogalonate","pmd":13.979}
{"X":5954,"KEGG":"R09328","RHEA_ID":44359,"DIRECTION":"BI","MASTER_ID":44356,"compounds":"nogalaviketone <=> methyl nogalonate","pmd":0}
{"X":5955,"KEGG":"R09331","RHEA_ID":41567,"DIRECTION":"BI","MASTER_ID":41564,"compounds":"aklavinone + dTDP-beta-L-rhodosamine <=> aclacinomycin T + dTDP + 2 H(+)","pmd":10.093}
{"X":5956,"KEGG":"R09332","RHEA_ID":41571,"DIRECTION":"BI","MASTER_ID":41568,"compounds":"aclacinomycin T + dTDP-2-deoxy-beta-L-fucose <=> aclacinomycin S + dTDP + H(+)","pmd":130.063}
{"X":5957,"KEGG":"R09334","RHEA_ID":37426,"DIRECTION":"BI","MASTER_ID":37423,"compounds":"aclacinomycin N + O2 <=> aclacinomycin A + H2O2","pmd":2.016}
{"X":5958,"KEGG":"R09335","RHEA_ID":37794,"DIRECTION":"BI","MASTER_ID":37791,"compounds":"aclacinomycin A + O2 <=> aclacinomycin Y + H2O2","pmd":2.016}
{"X":5959,"KEGG":"R09359","RHEA_ID":54663,"DIRECTION":"BI","MASTER_ID":54660,"metacyc":"RXN-11732","compounds":"an aromatic (S)-hydroxynitrile <=> an aromatic aldehyde + hydrogen cyanide"}
{"X":5960,"KEGG":"R09363","RHEA_ID":36610,"DIRECTION":"BI","MASTER_ID":36607,"compounds":"2-oxoglutarate + L-arginine + O2 <=> (2S,3S)-hydroxyarginine + CO2 + succinate","pmd":15.995}
{"X":5961,"KEGG":"R09363","RHEA_ID":36610,"DIRECTION":"BI","MASTER_ID":36607,"compounds":"2-oxoglutarate + L-arginine + O2 <=> (2S,3S)-hydroxyarginine + CO2 + succinate","pmd":27.995}
{"X":5962,"KEGG":"R09364","RHEA_ID":38162,"DIRECTION":"BI","MASTER_ID":38159,"metacyc":"RXN-14636","compounds":"(2S,3S)-hydroxyarginine <=> (2S,3R)-capreomycidine + H2O","pmd":18.011}
{"X":5963,"KEGG":"R09365","RHEA_ID":45019,"DIRECTION":"BI","MASTER_ID":45016,"compounds":"5-methyltetrahydropteroyltri-L-glutamate + L-selenohomocysteine <=> L-selenomethionine + tetrahydropteroyltri-L-glutamate","pmd":14.016}
{"X":5964,"KEGG":"R09375","RHEA_ID":27277,"DIRECTION":"BI","MASTER_ID":27274,"compounds":"2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) <=> 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADH","pmd":2.016}
{"X":5965,"KEGG":"R09375","RHEA_ID":27277,"DIRECTION":"BI","MASTER_ID":27274,"compounds":"2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) <=> 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADH","pmd":310.036}
{"X":5966,"KEGG":"R09376","RHEA_ID":27281,"DIRECTION":"BI","MASTER_ID":27278,"compounds":"2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) <=> 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADPH","pmd":2.016}
{"X":5967,"KEGG":"R09376","RHEA_ID":27281,"DIRECTION":"BI","MASTER_ID":27278,"compounds":"2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) <=> 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADPH","pmd":390.002}
{"X":5968,"KEGG":"R09378","RHEA_ID":28249,"DIRECTION":"BI","MASTER_ID":28246,"compounds":"(R)-pantoate + ATP <=> (R)-4-phosphopantoate + ADP + H(+)","pmd":79.966}
{"X":5969,"KEGG":"R09379","RHEA_ID":27933,"DIRECTION":"BI","MASTER_ID":27930,"compounds":"(R)-4-phosphopantoate + ATP + beta-alanine <=> (R)-4'-phosphopantothenate + AMP + diphosphate + H(+)","pmd":159.933}
{"X":5970,"KEGG":"R09379","RHEA_ID":27933,"DIRECTION":"BI","MASTER_ID":27930,"compounds":"(R)-4-phosphopantoate + ATP + beta-alanine <=> (R)-4'-phosphopantothenate + AMP + diphosphate + H(+)","pmd":71.037}
{"X":5971,"KEGG":"R09380","RHEA_ID":42303,"DIRECTION":"BI","MASTER_ID":42300,"compounds":"a fatty acyl-[ACP] + sn-glycerol 3-phosphate <=> a 1-acyl-sn-glycero-3-phosphate + holo-[ACP]"}
{"X":5972,"KEGG":"R09381","RHEA_ID":42299,"DIRECTION":"BI","MASTER_ID":42296,"compounds":"a 1-acyl-sn-glycero-3-phosphate + a fatty acyl-[ACP] <=> a 1,2-diacyl-sn-glycero-3-phosphate + holo-[ACP]"}
{"X":5973,"KEGG":"R09382","RHEA_ID":14436,"DIRECTION":"BI","MASTER_ID":14433,"compounds":"a tRNA precursor + ATP + 2 CTP <=> a tRNA with a 3' CCA end + 3 diphosphate"}
{"X":5974,"KEGG":"R09385","RHEA_ID":26092,"DIRECTION":"BI","MASTER_ID":26089,"compounds":"(4S)-limonene + H(+) + NADH + O2 <=> H2O + limonene 1,2-epoxide + NAD(+)","pmd":513.005}
{"X":5975,"KEGG":"R09385","RHEA_ID":26092,"DIRECTION":"BI","MASTER_ID":26089,"compounds":"(4S)-limonene + H(+) + NADH + O2 <=> H2O + limonene 1,2-epoxide + NAD(+)","pmd":15.995}
{"X":5976,"KEGG":"R09388","RHEA_ID":32382,"DIRECTION":"BI","MASTER_ID":32379,"metacyc":"RXN-9948","compounds":"(1R,2R,4S)-limonene-1,2-diol + NAD(+) <=> (1R,4S)-1-hydroxylimonen-2-one + H(+) + NADH","pmd":496.002}
{"X":5977,"KEGG":"R09388","RHEA_ID":32382,"DIRECTION":"BI","MASTER_ID":32379,"metacyc":"RXN-9948","compounds":"(1R,2R,4S)-limonene-1,2-diol + NAD(+) <=> (1R,4S)-1-hydroxylimonen-2-one + H(+) + NADH","pmd":2.016}
{"X":5978,"KEGG":"R09389","RHEA_ID":26088,"DIRECTION":"BI","MASTER_ID":26085,"compounds":"(4S)-limonene + H(+) + NADPH + O2 <=> H2O + limonene 1,2-epoxide + NADP(+)","pmd":15.995}
{"X":5979,"KEGG":"R09389","RHEA_ID":26088,"DIRECTION":"BI","MASTER_ID":26085,"compounds":"(4S)-limonene + H(+) + NADPH + O2 <=> H2O + limonene 1,2-epoxide + NADP(+)","pmd":592.971}
{"X":5980,"KEGG":"R09390","RHEA_ID":53415,"DIRECTION":"BI","MASTER_ID":53412,"compounds":"(1R,4S)-1-hydroxylimonen-2-one + H(+) + NADPH + O2 <=> (4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)","pmd":15.995}
{"X":5981,"KEGG":"R09390","RHEA_ID":53415,"DIRECTION":"BI","MASTER_ID":53412,"compounds":"(1R,4S)-1-hydroxylimonen-2-one + H(+) + NADPH + O2 <=> (4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)","pmd":560.981}
{"X":5982,"KEGG":"R09391","RHEA_ID":54879,"DIRECTION":"BI","MASTER_ID":54876,"compounds":"(4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one <=> (3S)-3-isopropenyl-6-oxoheptanoate + H(+)","pmd":0}
{"X":5983,"KEGG":"R09392","RHEA_ID":54883,"DIRECTION":"BI","MASTER_ID":54880,"compounds":"(4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one <=> (3R)-3-isopropenyl-6-oxoheptanoate + H(+)","pmd":0}
{"X":5984,"KEGG":"R09393","RHEA_ID":26100,"DIRECTION":"BI","MASTER_ID":26097,"compounds":"(4R)-limonene + H(+) + NADPH + O2 <=> H2O + limonene 1,2-epoxide + NADP(+)","pmd":15.995}
{"X":5985,"KEGG":"R09393","RHEA_ID":26100,"DIRECTION":"BI","MASTER_ID":26097,"compounds":"(4R)-limonene + H(+) + NADPH + O2 <=> H2O + limonene 1,2-epoxide + NADP(+)","pmd":592.971}
{"X":5986,"KEGG":"R09394","RHEA_ID":49579,"DIRECTION":"BI","MASTER_ID":49576,"compounds":"AH2 + GTP + S-adenosyl-L-methionine <=> (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine","pmd":0}
{"X":5987,"KEGG":"R09394","RHEA_ID":49579,"DIRECTION":"BI","MASTER_ID":49576,"compounds":"AH2 + GTP + S-adenosyl-L-methionine <=> (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine","pmd":124.853}
{"X":5988,"KEGG":"R09397","RHEA_ID":30522,"DIRECTION":"BI","MASTER_ID":30519,"compounds":"GTP + H(+) + phosphoenolpyruvate <=> diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine","pmd":345.047}
{"X":5989,"KEGG":"R09397","RHEA_ID":30522,"DIRECTION":"BI","MASTER_ID":30519,"compounds":"GTP + H(+) + phosphoenolpyruvate <=> diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine","pmd":7.945}
{"X":5990,"KEGG":"R09401","RHEA_ID":42335,"DIRECTION":"BI","MASTER_ID":42332,"compounds":"ATP + L-glutamate + oxidized coenzyme F420-2 <=> ADP + H(+) + oxidized coenzyme alpha-F420-3 + phosphate","pmd":279.976}
{"X":5991,"KEGG":"R09401","RHEA_ID":42335,"DIRECTION":"BI","MASTER_ID":42332,"compounds":"ATP + L-glutamate + oxidized coenzyme F420-2 <=> ADP + H(+) + oxidized coenzyme alpha-F420-3 + phosphate","pmd":129.043}
{"X":5992,"KEGG":"R09401","RHEA_ID":42335,"DIRECTION":"BI","MASTER_ID":42332,"compounds":"ATP + L-glutamate + oxidized coenzyme F420-2 <=> ADP + H(+) + oxidized coenzyme alpha-F420-3 + phosphate","pmd":79.966}
{"X":5993,"KEGG":"R09402","RHEA_ID":27416,"DIRECTION":"BI","MASTER_ID":27413,"compounds":"2-oxoglutarate + codeine + O2 <=> CO2 + formaldehyde + morphine + succinate","pmd":14.016}
{"X":5994,"KEGG":"R09402","RHEA_ID":27416,"DIRECTION":"BI","MASTER_ID":27413,"compounds":"2-oxoglutarate + codeine + O2 <=> CO2 + formaldehyde + morphine + succinate","pmd":27.995}
{"X":5995,"KEGG":"R09403","RHEA_ID":28605,"DIRECTION":"BI","MASTER_ID":28602,"compounds":"L-isoleucine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (1E,2S)-2-methylbutanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]","pmd":30.011}
{"X":5996,"KEGG":"R09428","RHEA_ID":21035,"DIRECTION":"BI","MASTER_ID":21032,"compounds":"glucuronate acceptor + UDP-alpha-D-glucuronate <=> acceptor beta-D-glucuronoside + H(+) + UDP","pmd":176.032}
{"X":5997,"KEGG":"R09445","RHEA_ID":30218,"DIRECTION":"BI","MASTER_ID":30215,"compounds":"a menaquinol + 2 nitric oxide <=> a menaquinone + H2O + nitrous oxide"}
{"X":5998,"KEGG":"R09446","RHEA_ID":29614,"DIRECTION":"BI","MASTER_ID":29611,"metacyc":"RXN-14137","compounds":"H2O + NADP(+) + nitrous oxide <=> H(+) + NADPH + 2 nitric oxide"}
{"X":5999,"KEGG":"R09446","RHEA_ID":29614,"DIRECTION":"BI","MASTER_ID":29611,"metacyc":"RXN-12112","compounds":"H2O + NADP(+) + nitrous oxide <=> H(+) + NADPH + 2 nitric oxide"}
{"X":6000,"KEGG":"R09447","RHEA_ID":36338,"DIRECTION":"BI","MASTER_ID":36335,"compounds":"D-glucuronate + H2O + NAD(+) <=> D-glucarate + 2 H(+) + NADH","pmd":15.995}
{"X":6001,"KEGG":"R09447","RHEA_ID":36338,"DIRECTION":"BI","MASTER_ID":36335,"compounds":"D-glucuronate + H2O + NAD(+) <=> D-glucarate + 2 H(+) + NADH","pmd":454.079}
{"X":6002,"KEGG":"R09451","RHEA_ID":40202,"DIRECTION":"BI","MASTER_ID":40199,"compounds":"hexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 16-hydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":6003,"KEGG":"R09452","RHEA_ID":41731,"DIRECTION":"BI","MASTER_ID":41728,"compounds":"(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":6004,"KEGG":"R09470","RHEA_ID":36306,"DIRECTION":"BI","MASTER_ID":36303,"compounds":"an acyl-CoA + 2 H(+) + 2 NADPH <=> a long-chain primary fatty alcohol + CoA + 2 NADP(+)","pmd":22.024}
{"X":6005,"KEGG":"R09472","RHEA_ID":33930,"DIRECTION":"BI","MASTER_ID":33927,"compounds":"4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 H(+) + 2 NADH + O2 <=> 2,5-dihydroxypyridine + H2O + 2 NAD(+) + succinate semialdehyde","pmd":554.093}
{"X":6006,"KEGG":"R09472","RHEA_ID":33930,"DIRECTION":"BI","MASTER_ID":33927,"compounds":"4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 H(+) + 2 NADH + O2 <=> 2,5-dihydroxypyridine + H2O + 2 NAD(+) + succinate semialdehyde","pmd":84.021}
{"X":6007,"KEGG":"R09473","RHEA_ID":27420,"DIRECTION":"BI","MASTER_ID":27417,"compounds":"2 [Fe(III)cytochrome] + H2O + nicotinate <=> 6-hydroxynicotinate + 2 [Fe(II)cytochrome] + 2 H(+)","pmd":15.995}
{"X":6008,"KEGG":"R09475","RHEA_ID":31342,"DIRECTION":"BI","MASTER_ID":31339,"compounds":"acetate + ATP + holo-[ACP] <=> acetyl-[ACP] + AMP + diphosphate","pmd":159.933}
{"X":6009,"KEGG":"R09476","RHEA_ID":30434,"DIRECTION":"BI","MASTER_ID":30431,"compounds":"(S)-2,3-epoxysqualene <=> taraxerol","pmd":0}
{"X":6010,"KEGG":"R09477","RHEA_ID":27444,"DIRECTION":"BI","MASTER_ID":27441,"metacyc":"RXN-11315","compounds":"NAD(+) + xylitol <=> D-xylose + H(+) + NADH","pmd":2.016}
{"X":6011,"KEGG":"R09477","RHEA_ID":27444,"DIRECTION":"BI","MASTER_ID":27441,"metacyc":"RXN-11315","compounds":"NAD(+) + xylitol <=> D-xylose + H(+) + NADH","pmd":514.064}
{"X":6012,"KEGG":"R09478","RHEA_ID":28081,"DIRECTION":"BI","MASTER_ID":28078,"metacyc":"RXN-9009","compounds":"2-hydroxyethylphosphonate + NAD(+) <=> H(+) + NADH + phosphonoacetaldehyde","pmd":540.124}
{"X":6013,"KEGG":"R09478","RHEA_ID":28081,"DIRECTION":"BI","MASTER_ID":28078,"metacyc":"RXN-9009","compounds":"2-hydroxyethylphosphonate + NAD(+) <=> H(+) + NADH + phosphonoacetaldehyde","pmd":2.016}
{"X":6014,"KEGG":"R09479","RHEA_ID":26445,"DIRECTION":"BI","MASTER_ID":26442,"compounds":"a ubiquinone + ethanol <=> a ubiquinol + acetaldehyde"}
{"X":6015,"KEGG":"R09480","RHEA_ID":51151,"DIRECTION":"BI","MASTER_ID":51148,"metacyc":"RXN-11335","compounds":"a primary alcohol + 2 oxidized [azurin] <=> an aldehyde + 2 H(+) + 2 reduced [azurin]"}
{"X":6016,"KEGG":"R09482","RHEA_ID":24463,"DIRECTION":"BI","MASTER_ID":24460,"compounds":"H(+) + malonyl-[ACP] <=> acetyl-[ACP] + CO2"}
{"X":6017,"KEGG":"R09483","RHEA_ID":25899,"DIRECTION":"BI","MASTER_ID":25896,"compounds":"H(+) + malonate <=> acetate + CO2"}
{"X":6018,"KEGG":"R09484","RHEA_ID":54183,"DIRECTION":"BI","MASTER_ID":54180,"compounds":"a long-chain fatty aldehyde + holo-[ACP] + NAD(+) <=> a long-chain fatty acyl-[ACP] + H(+) + NADH"}
{"X":6019,"KEGG":"R09485","RHEA_ID":54179,"DIRECTION":"BI","MASTER_ID":54176,"compounds":"a long-chain fatty aldehyde + holo-[ACP] + NADP(+) <=> a long-chain fatty acyl-[ACP] + H(+) + NADPH"}
{"X":6020,"KEGG":"R09487","RHEA_ID":30374,"DIRECTION":"BI","MASTER_ID":30371,"metacyc":"RXN-12237","compounds":"(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O <=> (-)-geosmin + acetone","pmd":40.031}
{"X":6021,"KEGG":"R09488","RHEA_ID":31018,"DIRECTION":"BI","MASTER_ID":31015,"metacyc":"RXN-12341","compounds":"H(+) + indole-3-carboxylate <=> CO2 + indole","pmd":43.99}
{"X":6022,"KEGG":"R09491","RHEA_ID":25362,"DIRECTION":"BI","MASTER_ID":25359,"compounds":"(3Z)-phycoerythrobilin + 2 oxidized 2[4Fe-4S]-[ferredoxin] <=> biliverdin IXalpha + 4 H(+) + 2 reduced 2[4Fe-4S]-[ferredoxin]","pmd":4.031}
{"X":6023,"KEGG":"R09492","RHEA_ID":30262,"DIRECTION":"BI","MASTER_ID":30259,"compounds":"2 a menaquinol + O2 <=> 2 a menaquinone + 2 H2O"}
{"X":6024,"KEGG":"R09493","RHEA_ID":45999,"DIRECTION":"BI","MASTER_ID":45996,"compounds":"a D-alpha-amino acid + a quinone + H2O <=> a 2-oxocarboxylate + a quinol + NH4(+)"}
{"X":6025,"KEGG":"R09494","RHEA_ID":48595,"DIRECTION":"BI","MASTER_ID":48592,"metacyc":"RXN-11237","compounds":"a quinone + formate + H(+) <=> a quinol + CO2"}
{"X":6026,"KEGG":"R09495","RHEA_ID":28213,"DIRECTION":"BI","MASTER_ID":28210,"compounds":"H2O + L-saccharopine + O2 <=> (S)-2-amino-6-oxohexanoate + H2O2 + L-glutamate","pmd":129.079}
{"X":6027,"KEGG":"R09496","RHEA_ID":27309,"DIRECTION":"BI","MASTER_ID":27306,"metacyc":"RXN-11185","compounds":"A + D-proline <=> 1-pyrroline-2-carboxylate + AH2","pmd":2.016}
{"X":6028,"KEGG":"R09497","RHEA_ID":56147,"DIRECTION":"BI","MASTER_ID":56144,"compounds":"a quinol + nitrate <=> a quinone + H2O + nitrite"}
{"X":6029,"KEGG":"R09498","RHEA_ID":30222,"DIRECTION":"BI","MASTER_ID":30219,"compounds":"dimethyl sulfoxide + H2O + NAD(+) <=> dimethyl sulfone + H(+) + NADH"}
{"X":6030,"KEGG":"R09499","RHEA_ID":30226,"DIRECTION":"BI","MASTER_ID":30223,"compounds":"2 [Fe(III)cytochrome c] + hydrogen sulfide <=> 2 [Fe(II)cytochrome c] + H(+) + sulfur"}
{"X":6031,"KEGG":"R09500","RHEA_ID":30230,"DIRECTION":"BI","MASTER_ID":30227,"compounds":"2 [Fe(III)-cytochrome c2] + dimethyl sulfide + H2O <=> 2 [Fe(II)-cytochrome c2] + dimethyl sulfoxide + 2 H(+)"}
{"X":6032,"KEGG":"R09502","RHEA_ID":42339,"DIRECTION":"BI","MASTER_ID":42336,"metacyc":"RXN-9944","compounds":"[thioredoxin]-disulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> [thioredoxin]-dithiol + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":6033,"KEGG":"R09503","RHEA_ID":36362,"DIRECTION":"BI","MASTER_ID":36359,"compounds":"2 a plastoquinone + 2 H2O + 4 hnu <=> 2 a plastoquinol + O2"}
{"X":6034,"KEGG":"R09504","RHEA_ID":30258,"DIRECTION":"BI","MASTER_ID":30255,"compounds":"2 a ubiquinol + O2 <=> 2 a ubiquinone + 2 H2O"}
{"X":6035,"KEGG":"R09506","RHEA_ID":28217,"DIRECTION":"BI","MASTER_ID":28214,"metacyc":"RXN-12122","compounds":"[thioredoxin]-dithiol + prostaglandin H2 <=> [thioredoxin]-disulfide + prostaglandin F2alpha","pmd":2.016}
{"X":6036,"KEGG":"R09508","RHEA_ID":30282,"DIRECTION":"BI","MASTER_ID":30279,"compounds":"2 H2 + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 3 H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":6037,"KEGG":"R09509","RHEA_ID":43339,"DIRECTION":"BI","MASTER_ID":43336,"compounds":"H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + n Na(+)(in) <=> CO2 + N(6)-biotinyl-L-lysyl-[protein] + n Na(+)(out)"}
{"X":6038,"KEGG":"R09510","RHEA_ID":61951,"DIRECTION":"BI","MASTER_ID":61948,"compounds":"2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl-[protein] + O2 <=> CO2 + formaldehyde + N(6)-methyl-L-lysyl-[protein] + succinate","pmd":27.995}
{"X":6039,"KEGG":"R09511","RHEA_ID":60927,"DIRECTION":"BI","MASTER_ID":60924,"compounds":"2-oxoglutarate + N(6)-methyl-L-lysyl-[protein] + O2 <=> CO2 + formaldehyde + L-lysyl-[protein] + succinate","pmd":27.995}
{"X":6040,"KEGG":"R09512","RHEA_ID":27845,"DIRECTION":"BI","MASTER_ID":27842,"compounds":"9H-carbazole + H(+) + NADPH + O2 <=> 2'-aminobiphenyl-2,3-diol + NADP(+)","pmd":544.012}
{"X":6041,"KEGG":"R09512","RHEA_ID":27845,"DIRECTION":"BI","MASTER_ID":27842,"compounds":"9H-carbazole + H(+) + NADPH + O2 <=> 2'-aminobiphenyl-2,3-diol + NADP(+)","pmd":34.006}
{"X":6042,"KEGG":"R09513","RHEA_ID":26080,"DIRECTION":"BI","MASTER_ID":26077,"compounds":"methanesulfonate + NADH + O2 <=> formaldehyde + H2O + NAD(+) + sulfite"}
{"X":6043,"KEGG":"R09514","RHEA_ID":27332,"DIRECTION":"BI","MASTER_ID":27329,"compounds":"H(+) + NADH + O2 + urate <=> 5-hydroxyisourate + H2O + NAD(+)","pmd":15.995}
{"X":6044,"KEGG":"R09514","RHEA_ID":27332,"DIRECTION":"BI","MASTER_ID":27329,"compounds":"H(+) + NADH + O2 + urate <=> 5-hydroxyisourate + H2O + NAD(+)","pmd":481.102}
{"X":6045,"KEGG":"R09515","RHEA_ID":24967,"DIRECTION":"BI","MASTER_ID":24964,"compounds":"calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> calcitetrol + H2O + 2 oxidized [adrenodoxin]","pmd":15.995}
{"X":6046,"KEGG":"R09516","RHEA_ID":24971,"DIRECTION":"BI","MASTER_ID":24968,"compounds":"calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> H2O + 2 oxidized [adrenodoxin] + secalciferol","pmd":15.995}
{"X":6047,"KEGG":"R09517","RHEA_ID":27549,"DIRECTION":"BI","MASTER_ID":27546,"compounds":"anthranilate + FADH2 + O2 <=> 3-hydroxyanthranilate + FAD + H(+) + H2O","pmd":15.995}
{"X":6048,"KEGG":"R09517","RHEA_ID":27549,"DIRECTION":"BI","MASTER_ID":27546,"compounds":"anthranilate + FADH2 + O2 <=> 3-hydroxyanthranilate + FAD + H(+) + H2O","pmd":2.016}
{"X":6049,"KEGG":"R09518","RHEA_ID":30358,"DIRECTION":"BI","MASTER_ID":30355,"compounds":"a quinol + methane + O2 <=> a quinone + H2O + methanol"}
{"X":6050,"KEGG":"R09519","RHEA_ID":27344,"DIRECTION":"BI","MASTER_ID":27341,"compounds":"AH2 + NH4(+) + O2 <=> A + H(+) + H2O + hydroxylamine"}
{"X":6051,"KEGG":"R09520","RHEA_ID":30154,"DIRECTION":"BI","MASTER_ID":30151,"metacyc":"RXN-13750","compounds":"FADH2 + NADP(+) <=> FAD + 2 H(+) + NADPH","pmd":42.082}
{"X":6052,"KEGG":"R09520","RHEA_ID":30154,"DIRECTION":"BI","MASTER_ID":30151,"metacyc":"RXN-13750","compounds":"FADH2 + NADP(+) <=> FAD + 2 H(+) + NADPH","pmd":2.016}
{"X":6053,"KEGG":"R09521","RHEA_ID":27456,"DIRECTION":"BI","MASTER_ID":27453,"compounds":"iodide + L-tyrosine + NADP(+) <=> 3-iodo-L-tyrosine + NADPH","pmd":125.897}
{"X":6054,"KEGG":"R09521","RHEA_ID":27456,"DIRECTION":"BI","MASTER_ID":27453,"compounds":"iodide + L-tyrosine + NADP(+) <=> 3-iodo-L-tyrosine + NADPH","pmd":437.113}
{"X":6055,"KEGG":"R09522","RHEA_ID":27460,"DIRECTION":"BI","MASTER_ID":27457,"compounds":"3-iodo-L-tyrosine + iodide + NADP(+) <=> 3,5-diiodo-L-tyrosine + H(+) + NADPH","pmd":125.897}
{"X":6056,"KEGG":"R09522","RHEA_ID":27460,"DIRECTION":"BI","MASTER_ID":27457,"compounds":"3-iodo-L-tyrosine + iodide + NADP(+) <=> 3,5-diiodo-L-tyrosine + H(+) + NADPH","pmd":311.216}
{"X":6057,"KEGG":"R09523","RHEA_ID":27360,"DIRECTION":"BI","MASTER_ID":27357,"compounds":"iodide + S-adenosyl-L-methionine <=> iodomethane + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6058,"KEGG":"R09524","RHEA_ID":27372,"DIRECTION":"BI","MASTER_ID":27369,"compounds":"acetoin + CoA + NAD(+) <=> acetaldehyde + acetyl-CoA + H(+) + NADH","pmd":145.009}
{"X":6059,"KEGG":"R09524","RHEA_ID":27372,"DIRECTION":"BI","MASTER_ID":27369,"compounds":"acetoin + CoA + NAD(+) <=> acetaldehyde + acetyl-CoA + H(+) + NADH","pmd":42.011}
{"X":6060,"KEGG":"R09525","RHEA_ID":28646,"DIRECTION":"BI","MASTER_ID":28643,"compounds":"(2E,6E)-farnesyl diphosphate <=> alpha-zingiberene + diphosphate","pmd":177.943}
{"X":6061,"KEGG":"R09526","RHEA_ID":29498,"DIRECTION":"BI","MASTER_ID":29495,"compounds":"(2E,6E)-farnesyl diphosphate + H2O <=> beta-eudesmol + diphosphate","pmd":159.933}
{"X":6062,"KEGG":"R09527","RHEA_ID":28253,"DIRECTION":"BI","MASTER_ID":28250,"metacyc":"RXN-11497","compounds":"acetyl-CoA + H(+) + malonyl-CoA <=> acetoacetyl-CoA + CO2 + CoA","pmd":42.01}
{"X":6063,"KEGG":"R09527","RHEA_ID":28253,"DIRECTION":"BI","MASTER_ID":28250,"metacyc":"RXN-11497","compounds":"acetyl-CoA + H(+) + malonyl-CoA <=> acetoacetyl-CoA + CO2 + CoA","pmd":1.979}
{"X":6064,"KEGG":"R09528","RHEA_ID":30414,"DIRECTION":"BI","MASTER_ID":30411,"compounds":"benzoyl-CoA + benzyl alcohol <=> benzyl benzoate + CoA","pmd":104.026}
{"X":6065,"KEGG":"R09529","RHEA_ID":28317,"DIRECTION":"BI","MASTER_ID":28314,"compounds":"baicalein + UDP-alpha-D-glucuronate <=> baicalin + UDP","pmd":133.949}
{"X":6066,"KEGG":"R09531","RHEA_ID":30518,"DIRECTION":"BI","MASTER_ID":30515,"metacyc":"RXN-11190","compounds":"S-adenosyl 3-(methylsulfanyl)propylamine + spermidine <=> H(+) + S-methyl-5'-thioadenosine + thermospermine","pmd":57.058}
{"X":6067,"KEGG":"R09531","RHEA_ID":30518,"DIRECTION":"BI","MASTER_ID":30515,"metacyc":"RXN-11190","compounds":"S-adenosyl 3-(methylsulfanyl)propylamine + spermidine <=> H(+) + S-methyl-5'-thioadenosine + thermospermine","pmd":58.066}
{"X":6068,"KEGG":"R09532","RHEA_ID":27384,"DIRECTION":"BI","MASTER_ID":27381,"compounds":"(2R)-2,3-bisphosphoglycerate + H2O <=> (2R)-2-phosphoglycerate + phosphate","pmd":79.966}
{"X":6069,"KEGG":"R09533","RHEA_ID":28133,"DIRECTION":"BI","MASTER_ID":28130,"compounds":"baicalin + H2O <=> baicalein + D-glucuronate + H(+)","pmd":176.032}
{"X":6070,"KEGG":"R09533","RHEA_ID":30478,"DIRECTION":"BI","MASTER_ID":30475,"compounds":"H2O + oroxylin A 7-O-beta-D-glucuronate <=> D-glucuronate + H(+) + oroxylin A","pmd":176.032}
{"X":6071,"KEGG":"R09534","RHEA_ID":28137,"DIRECTION":"BI","MASTER_ID":28134,"compounds":"H2O + hesperidin <=> hesperetin + rutinose","pmd":284.068}
{"X":6072,"KEGG":"R09536","RHEA_ID":26139,"DIRECTION":"BI","MASTER_ID":26136,"compounds":"H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + ethanolamine","pmd":43.042}
{"X":6073,"KEGG":"R09537","RHEA_ID":26509,"DIRECTION":"BI","MASTER_ID":26506,"metacyc":"RXN-10756","compounds":"(9Z)-octadecenamide + H2O <=> (9Z)-octadecenoate + NH4(+)","pmd":0.984}
{"X":6074,"KEGG":"R09538","RHEA_ID":32490,"DIRECTION":"BI","MASTER_ID":32487,"metacyc":"RXN-9614","compounds":"CDP-choline + H2O <=> CMP + 2 H(+) + phosphocholine","pmd":165.055}
{"X":6075,"KEGG":"R09539","RHEA_ID":30706,"DIRECTION":"BI","MASTER_ID":30703,"compounds":"H(+) + salicylate <=> CO2 + phenol"}
{"X":6076,"KEGG":"R09540","RHEA_ID":30266,"DIRECTION":"BI","MASTER_ID":30263,"compounds":"H2O2 + 2 L-ascorbate <=> 2 H2O + 2 monodehydro-L-ascorbate radical"}
{"X":6077,"KEGG":"R09541","RHEA_ID":28798,"DIRECTION":"BI","MASTER_ID":28795,"compounds":"2 a Fe(II)-siderophore + H(+) + NADP(+) <=> 2 a Fe(III)-siderophore + NADPH"}
{"X":6078,"KEGG":"R09542","RHEA_ID":30410,"DIRECTION":"BI","MASTER_ID":30407,"compounds":"hnu + oxidized [2Fe-2S]-[ferredoxin] + reduced [plastocyanin] <=> oxidized [plastocyanin] + reduced [2Fe-2S]-[ferredoxin]"}
{"X":6079,"KEGG":"R09543","RHEA_ID":17108,"DIRECTION":"BI","MASTER_ID":17105,"compounds":"malonyl-[ACP] + S-adenosyl-L-methionine <=> malonyl-[ACP] methyl ester + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6080,"KEGG":"R09544","RHEA_ID":26005,"DIRECTION":"BI","MASTER_ID":26002,"metacyc":"RXN-11106","compounds":"D-arabinitol 1-phosphate + NAD(+) <=> D-xylulose 5-phosphate + H(+) + NADH","pmd":2.016}
{"X":6081,"KEGG":"R09544","RHEA_ID":26005,"DIRECTION":"BI","MASTER_ID":26002,"metacyc":"RXN-11106","compounds":"D-arabinitol 1-phosphate + NAD(+) <=> D-xylulose 5-phosphate + H(+) + NADH","pmd":434.098}
{"X":6082,"KEGG":"R09545","RHEA_ID":28077,"DIRECTION":"BI","MASTER_ID":28074,"compounds":"(2R)-3-sulfopropanediol + H2O + 2 NAD(+) <=> (R)-3-sulfolactate + 3 H(+) + 2 NADH","pmd":13.979}
{"X":6083,"KEGG":"R09545","RHEA_ID":28077,"DIRECTION":"BI","MASTER_ID":28074,"compounds":"(2R)-3-sulfopropanediol + H2O + 2 NAD(+) <=> (R)-3-sulfolactate + 3 H(+) + 2 NADH","pmd":494.128}
{"X":6084,"KEGG":"R09546","RHEA_ID":30162,"DIRECTION":"BI","MASTER_ID":30159,"compounds":"germacra-1(10),4,11(13)-trien-12-ol + NADP(+) <=> germacra-1(10),4,11(13)-trien-12-al + H(+) + NADPH"}
{"X":6085,"KEGG":"R09547","RHEA_ID":30166,"DIRECTION":"BI","MASTER_ID":30163,"compounds":"germacra-1(10),4,11(13)-trien-12-al + H2O + NADP(+) <=> germacra-1(10),4,11(13)-trien-12-oate + 2 H(+) + NADPH"}
{"X":6086,"KEGG":"R09548","RHEA_ID":30670,"DIRECTION":"BI","MASTER_ID":30667,"metacyc":"RXN-12449","compounds":"germacra-1(10),4,11(13)-trien-12-ol + H2O + 2 NADP(+) <=> germacra-1(10),4,11(13)-trien-12-oate + 3 H(+) + 2 NADPH","pmd":13.979}
{"X":6087,"KEGG":"R09549","RHEA_ID":61311,"DIRECTION":"BI","MASTER_ID":61308,"compounds":"(+)-(R)-germacrene A + O2 + reduced [NADPH--hemoprotein reductase] <=> germacra-1(10),4,11(13)-trien-12-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":6088,"KEGG":"R09550","RHEA_ID":27297,"DIRECTION":"BI","MASTER_ID":27294,"metacyc":"RXN-11283","compounds":"D-glucose 6-phosphate + H(+) + oxidized coenzyme F420-(gamma-Glu)(n) <=> 6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420-(gamma-Glu)(n)","pmd":2.016}
{"X":6089,"KEGG":"R09551","RHEA_ID":24881,"DIRECTION":"BI","MASTER_ID":24878,"compounds":"A + L-sorbopyranose <=> 1-dehydro-L-sorbose + AH2","pmd":2.016}
{"X":6090,"KEGG":"R09552","RHEA_ID":27541,"DIRECTION":"BI","MASTER_ID":27538,"compounds":"ethanol + N,N-dimethyl-4-nitrosoaniline <=> 4-(hydroxylamino)-N,N-dimethylaniline + acetaldehyde","pmd":2.016}
{"X":6091,"KEGG":"R09553","RHEA_ID":27545,"DIRECTION":"BI","MASTER_ID":27542,"compounds":"methanol + N,N-dimethyl-4-nitrosoaniline <=> 4-(hydroxylamino)-N,N-dimethylaniline + formaldehyde","pmd":2.016}
{"X":6092,"KEGG":"R09554","RHEA_ID":25394,"DIRECTION":"BI","MASTER_ID":25391,"compounds":"(3Z)-6-oxohex-3-enoyl-CoA + H2O + NADP(+) <=> cis-3,4-dehydroadipyl-CoA + 2 H(+) + NADPH","pmd":15.995}
{"X":6093,"KEGG":"R09554","RHEA_ID":25394,"DIRECTION":"BI","MASTER_ID":25391,"compounds":"(3Z)-6-oxohex-3-enoyl-CoA + H2O + NADP(+) <=> cis-3,4-dehydroadipyl-CoA + 2 H(+) + NADPH","pmd":149.064}
{"X":6094,"KEGG":"R09555","RHEA_ID":48315,"DIRECTION":"BI","MASTER_ID":48312,"compounds":"benzoyl-CoA + H(+) + NADPH + O2 <=> 2,3-epoxy-2,3-dihydrobenzoyl-CoA + H2O + NADP(+)","pmd":142.045}
{"X":6095,"KEGG":"R09555","RHEA_ID":48315,"DIRECTION":"BI","MASTER_ID":48312,"compounds":"benzoyl-CoA + H(+) + NADPH + O2 <=> 2,3-epoxy-2,3-dihydrobenzoyl-CoA + H2O + NADP(+)","pmd":15.995}
{"X":6096,"KEGG":"R09557","RHEA_ID":29598,"DIRECTION":"BI","MASTER_ID":29595,"metacyc":"RXN-11674","compounds":"CoA + NADP(+) + sulfoacetaldehyde <=> H(+) + NADPH + sulfoacetyl-CoA","pmd":144.999}
{"X":6097,"KEGG":"R09557","RHEA_ID":29598,"DIRECTION":"BI","MASTER_ID":29595,"metacyc":"RXN-11674","compounds":"CoA + NADP(+) + sulfoacetaldehyde <=> H(+) + NADPH + sulfoacetyl-CoA","pmd":621.108}
{"X":6098,"KEGG":"R09557","RHEA_ID":29598,"DIRECTION":"BI","MASTER_ID":29595,"metacyc":"RXN-11674","compounds":"CoA + NADP(+) + sulfoacetaldehyde <=> H(+) + NADPH + sulfoacetyl-CoA","pmd":22.024}
{"X":6099,"KEGG":"R09558","RHEA_ID":30430,"DIRECTION":"BI","MASTER_ID":30427,"compounds":"(2E,6E)-farnesyl diphosphate <=> (+)-germacrene D + diphosphate","pmd":177.943}
{"X":6100,"KEGG":"R09559","RHEA_ID":25374,"DIRECTION":"BI","MASTER_ID":25371,"metacyc":"RXN-9293","compounds":"(2S)-2-amino-4-deoxychorismate + FMN <=> 3-(1-carboxyvinyloxy)anthranilate + FMNH2","pmd":2.016}
{"X":6101,"KEGG":"R09560","RHEA_ID":27305,"DIRECTION":"BI","MASTER_ID":27302,"compounds":"7-chloro-L-tryptophan + O2 <=> 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2","pmd":2.016}
{"X":6102,"KEGG":"R09561","RHEA_ID":27436,"DIRECTION":"BI","MASTER_ID":27433,"compounds":"2 glutathione amide + NAD(+) <=> glutathione amide disulfide + H(+) + NADH","pmd":53.933}
{"X":6103,"KEGG":"R09561","RHEA_ID":27436,"DIRECTION":"BI","MASTER_ID":27433,"compounds":"2 glutathione amide + NAD(+) <=> glutathione amide disulfide + H(+) + NADH","pmd":304.084}
{"X":6104,"KEGG":"R09562","RHEA_ID":30234,"DIRECTION":"BI","MASTER_ID":30231,"compounds":"H2O + O2 + S-(2E,6E)-farnesyl-L-cysteine <=> (2E,6E)-farnesal + H2O2 + L-cysteine","pmd":105.025}
{"X":6105,"KEGG":"R09563","RHEA_ID":27440,"DIRECTION":"BI","MASTER_ID":27437,"compounds":"2 glutathione amide + H2O2 <=> glutathione amide disulfide + 2 H2O","pmd":304.084}
{"X":6106,"KEGG":"R09564","RHEA_ID":28221,"DIRECTION":"BI","MASTER_ID":28218,"metacyc":"RXN-11818","compounds":"chloride + H(+) + H2O2 <=> H2O + hypochlorous acid"}
{"X":6107,"KEGG":"R09564","RHEA_ID":28221,"DIRECTION":"BI","MASTER_ID":28218,"metacyc":"RXN-11816","compounds":"chloride + H(+) + H2O2 <=> H2O + hypochlorous acid"}
{"X":6108,"KEGG":"R09566","RHEA_ID":27396,"DIRECTION":"BI","MASTER_ID":27393,"compounds":"2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 <=> dichlorochromopyrrolate + H(+) + 2 H2O + NH4(+)","pmd":216.993}
{"X":6109,"KEGG":"R09567","RHEA_ID":27317,"DIRECTION":"BI","MASTER_ID":27314,"compounds":"dichlorochromopyrrolate + 6 H(+) + 4 NADH + 4 O2 <=> 2 CO2 + dichloroarcyriaflavin A + 6 H2O + 4 NAD(+)","pmd":272.118}
{"X":6110,"KEGG":"R09567","RHEA_ID":27317,"DIRECTION":"BI","MASTER_ID":27314,"compounds":"dichlorochromopyrrolate + 6 H(+) + 4 NADH + 4 O2 <=> 2 CO2 + dichloroarcyriaflavin A + 6 H2O + 4 NAD(+)","pmd":60.021}
{"X":6111,"KEGG":"R09568","RHEA_ID":27400,"DIRECTION":"BI","MASTER_ID":27397,"compounds":"4'-demethylrebeccamycin + H2O <=> beta-D-glucose + dichloroarcyriaflavin A","pmd":162.053}
{"X":6112,"KEGG":"R09569","RHEA_ID":27356,"DIRECTION":"BI","MASTER_ID":27353,"compounds":"4'-demethylrebeccamycin + S-adenosyl-L-methionine <=> H(+) + rebeccamycin + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6113,"KEGG":"R09570","RHEA_ID":26497,"DIRECTION":"BI","MASTER_ID":26494,"compounds":"chloride + FADH2 + L-tryptophan + O2 <=> 7-chloro-L-tryptophan + FAD + 2 H2O","pmd":2.016}
{"X":6114,"KEGG":"R09570","RHEA_ID":26497,"DIRECTION":"BI","MASTER_ID":26494,"compounds":"chloride + FADH2 + L-tryptophan + O2 <=> 7-chloro-L-tryptophan + FAD + 2 H2O","pmd":33.961}
{"X":6115,"KEGG":"R09571","RHEA_ID":28778,"DIRECTION":"BI","MASTER_ID":28775,"compounds":"dinoflagellate luciferin + O2 <=> H(+) + H2O + hnu + oxidized dinoflagellate luciferin","pmd":13.979}
{"X":6116,"KEGG":"R09572","RHEA_ID":20268,"DIRECTION":"BI","MASTER_ID":20265,"compounds":"2-oxoglutarate + L-proline + O2 <=> cis-3-hydroxy-L-proline + CO2 + succinate","pmd":2.963}
{"X":6117,"KEGG":"R09572","RHEA_ID":20268,"DIRECTION":"BI","MASTER_ID":20265,"compounds":"2-oxoglutarate + L-proline + O2 <=> cis-3-hydroxy-L-proline + CO2 + succinate","pmd":14.963}
{"X":6118,"KEGG":"R09573","RHEA_ID":28229,"DIRECTION":"BI","MASTER_ID":28226,"compounds":"(+)-5-epi-aristolochene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> capsidiol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]","pmd":31.99}
{"X":6119,"KEGG":"R09575","RHEA_ID":28233,"DIRECTION":"BI","MASTER_ID":28230,"compounds":"germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-costunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]","pmd":2.016}
{"X":6120,"KEGG":"R09576","RHEA_ID":28626,"DIRECTION":"BI","MASTER_ID":28623,"compounds":"(-)-vetispiradiene + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + solavetivol","pmd":15.995}
{"X":6121,"KEGG":"R09577","RHEA_ID":28630,"DIRECTION":"BI","MASTER_ID":28627,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + solavetivol <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + solavetivone","pmd":2.016}
{"X":6122,"KEGG":"R09579","RHEA_ID":24995,"DIRECTION":"BI","MASTER_ID":24992,"compounds":"L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":6123,"KEGG":"R09580","RHEA_ID":24999,"DIRECTION":"BI","MASTER_ID":24996,"compounds":"N-hydroxy-L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":6124,"KEGG":"R09581","RHEA_ID":25003,"DIRECTION":"BI","MASTER_ID":25000,"compounds":"H(+) + N,N-dihydroxy-L-phenylalanine <=> (E)-phenylacetaldehyde oxime + CO2 + H2O","pmd":62}
{"X":6125,"KEGG":"R09583","RHEA_ID":25008,"DIRECTION":"BI","MASTER_ID":25005,"compounds":"L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":6126,"KEGG":"R09584","RHEA_ID":25012,"DIRECTION":"BI","MASTER_ID":25009,"compounds":"N-hydroxy-L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":6127,"KEGG":"R09585","RHEA_ID":25016,"DIRECTION":"BI","MASTER_ID":25013,"compounds":"H(+) + N,N-dihydroxy-L-tryptophan <=> (E)-(indol-3-yl)acetaldehyde oxime + CO2 + H2O","pmd":62}
{"X":6128,"KEGG":"R09586","RHEA_ID":30354,"DIRECTION":"BI","MASTER_ID":30351,"compounds":"H(+) + NADH + O2 + pyrrole-2-carboxylate <=> 5-hydroxypyrrole-2-carboxylate + H2O + NAD(+)","pmd":15.995}
{"X":6129,"KEGG":"R09586","RHEA_ID":30354,"DIRECTION":"BI","MASTER_ID":30351,"compounds":"H(+) + NADH + O2 + pyrrole-2-carboxylate <=> 5-hydroxypyrrole-2-carboxylate + H2O + NAD(+)","pmd":538.098}
{"X":6130,"KEGG":"R09587","RHEA_ID":27340,"DIRECTION":"BI","MASTER_ID":27337,"compounds":"2 H(+) + O2 + progesterone + reduced 2[4Fe-4S]-[ferredoxin] <=> 15beta-hydroxyprogesterone + H2O + oxidized 2[4Fe-4S]-[ferredoxin]","pmd":15.995}
{"X":6131,"KEGG":"R09588","RHEA_ID":37350,"DIRECTION":"BI","MASTER_ID":37347,"compounds":"(R)-lactate + ATP + D-alanine <=> ADP + D-alanyl-(R)-lactate + phosphate","pmd":79.966}
{"X":6132,"KEGG":"R09590","RHEA_ID":10755,"DIRECTION":"BI","MASTER_ID":10752,"compounds":"[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n) + n ATP + n D-aspartate <=> [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + n ADP + n H(+) + n phosphate","pmd":79.966}
{"X":6133,"KEGG":"R09590","RHEA_ID":10755,"DIRECTION":"BI","MASTER_ID":10752,"compounds":"[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n) + n ATP + n D-aspartate <=> [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + n ADP + n H(+) + n phosphate","pmd":293.992}
{"X":6134,"KEGG":"R09592","RHEA_ID":13280,"DIRECTION":"BI","MASTER_ID":13277,"compounds":"[L-4-(L-arginin-2-N-yl)aspartate](n) + ATP + L-aspartate <=> [L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ADP + H(+) + phosphate","pmd":293.992}
{"X":6135,"KEGG":"R09592","RHEA_ID":13280,"DIRECTION":"BI","MASTER_ID":13277,"compounds":"[L-4-(L-arginin-2-N-yl)aspartate](n) + ATP + L-aspartate <=> [L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ADP + H(+) + phosphate","pmd":79.966}
{"X":6136,"KEGG":"R09593","RHEA_ID":23891,"DIRECTION":"BI","MASTER_ID":23888,"compounds":"[L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ATP + L-arginine <=> [L-4-(L-arginin-2-N-yl)aspartate](n+1) + ADP + H(+) + phosphate","pmd":79.966}
{"X":6137,"KEGG":"R09593","RHEA_ID":23891,"DIRECTION":"BI","MASTER_ID":23888,"compounds":"[L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ATP + L-arginine <=> [L-4-(L-arginin-2-N-yl)aspartate](n+1) + ADP + H(+) + phosphate","pmd":252.918}
{"X":6138,"KEGG":"R09594","RHEA_ID":30570,"DIRECTION":"BI","MASTER_ID":30567,"compounds":"5,6,7,8-tetrahydromethanopterin + ATP + L-glutamate <=> 5,6,7,8-tetrahydrosarcinapterin + ADP + H(+) + phosphate","pmd":79.966}
{"X":6139,"KEGG":"R09594","RHEA_ID":30570,"DIRECTION":"BI","MASTER_ID":30567,"compounds":"5,6,7,8-tetrahydromethanopterin + ATP + L-glutamate <=> 5,6,7,8-tetrahydrosarcinapterin + ADP + H(+) + phosphate","pmd":279.976}
{"X":6140,"KEGG":"R09594","RHEA_ID":30570,"DIRECTION":"BI","MASTER_ID":30567,"compounds":"5,6,7,8-tetrahydromethanopterin + ATP + L-glutamate <=> 5,6,7,8-tetrahydrosarcinapterin + ADP + H(+) + phosphate","pmd":129.043}
{"X":6141,"KEGG":"R09596","RHEA_ID":25276,"DIRECTION":"BI","MASTER_ID":25273,"compounds":"ATP + D-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate <=> ADP + H(+) + N(6)-(UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl)-D-lysine + phosphate","pmd":452.153}
{"X":6142,"KEGG":"R09596","RHEA_ID":25276,"DIRECTION":"BI","MASTER_ID":25273,"compounds":"ATP + D-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate <=> ADP + H(+) + N(6)-(UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl)-D-lysine + phosphate","pmd":280.924}
{"X":6143,"KEGG":"R09596","RHEA_ID":25276,"DIRECTION":"BI","MASTER_ID":25273,"compounds":"ATP + D-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate <=> ADP + H(+) + N(6)-(UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl)-D-lysine + phosphate","pmd":79.966}
{"X":6144,"KEGG":"R09597","RHEA_ID":43747,"DIRECTION":"BI","MASTER_ID":43744,"compounds":"ATP + cytidine(34) in tRNA(Ile2) + L-lysine <=> AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)","pmd":200.958}
{"X":6145,"KEGG":"R09597","RHEA_ID":43747,"DIRECTION":"BI","MASTER_ID":43744,"compounds":"ATP + cytidine(34) in tRNA(Ile2) + L-lysine <=> AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)","pmd":159.933}
{"X":6146,"KEGG":"R09598","RHEA_ID":34550,"DIRECTION":"BI","MASTER_ID":34547,"compounds":"ATP + cob(II)yrinate + H2O + L-glutamine <=> ADP + cob(II)yrinate c monoamide + H(+) + L-glutamate + phosphate","pmd":79.966}
{"X":6147,"KEGG":"R09598","RHEA_ID":34550,"DIRECTION":"BI","MASTER_ID":34547,"compounds":"ATP + cob(II)yrinate + H2O + L-glutamine <=> ADP + cob(II)yrinate c monoamide + H(+) + L-glutamate + phosphate","pmd":0.984}
{"X":6148,"KEGG":"R09599","RHEA_ID":34554,"DIRECTION":"BI","MASTER_ID":34551,"compounds":"ATP + cob(II)yrinate c monoamide + H2O + L-glutamine <=> ADP + cob(II)yrinate a,c diamide + H(+) + L-glutamate + phosphate","pmd":79.966}
{"X":6149,"KEGG":"R09599","RHEA_ID":34554,"DIRECTION":"BI","MASTER_ID":34551,"compounds":"ATP + cob(II)yrinate c monoamide + H2O + L-glutamine <=> ADP + cob(II)yrinate a,c diamide + H(+) + L-glutamate + phosphate","pmd":0.984}
{"X":6150,"KEGG":"R09600","RHEA_ID":24767,"DIRECTION":"BI","MASTER_ID":24764,"compounds":"UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate <=> UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate","pmd":0}
{"X":6151,"KEGG":"R09601","RHEA_ID":26388,"DIRECTION":"BI","MASTER_ID":26385,"compounds":"all-trans-8'-apo-beta-carotenal + O2 <=> (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + all-trans-retinal","pmd":132.094}
{"X":6152,"KEGG":"R09602","RHEA_ID":28245,"DIRECTION":"BI","MASTER_ID":28242,"compounds":"O2 + pratensein + reduced [NADPH--hemoprotein reductase] <=> 5-hydroxypseudobaptigenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]","pmd":2.016}
{"X":6153,"KEGG":"R09603","RHEA_ID":26400,"DIRECTION":"BI","MASTER_ID":26397,"compounds":"all-trans-zeaxanthin + 2 O2 <=> 2 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde","pmd":272.25}
{"X":6154,"KEGG":"R09604","RHEA_ID":30994,"DIRECTION":"BI","MASTER_ID":30991,"compounds":"beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> 24-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":6155,"KEGG":"R09605","RHEA_ID":30998,"DIRECTION":"BI","MASTER_ID":30995,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + sophoradiol <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + soyasapogenol B","pmd":15.995}
{"X":6156,"KEGG":"R09606","RHEA_ID":29510,"DIRECTION":"BI","MASTER_ID":29507,"compounds":"(2E,6E)-farnesyl diphosphate <=> (-)-alpha-gurjunene + diphosphate","pmd":177.943}
{"X":6157,"KEGG":"R09607","RHEA_ID":30474,"DIRECTION":"BI","MASTER_ID":30471,"compounds":"(2Z,6Z)-farnesyl diphosphate <=> (-)-endo-alpha-bergamotene + diphosphate","pmd":177.943}
{"X":6158,"KEGG":"R09608","RHEA_ID":30466,"DIRECTION":"BI","MASTER_ID":30463,"compounds":"(2Z,6Z)-farnesyl diphosphate <=> (+)-alpha-santalene + diphosphate","pmd":177.943}
{"X":6159,"KEGG":"R09609","RHEA_ID":30470,"DIRECTION":"BI","MASTER_ID":30467,"compounds":"(2Z,6Z)-farnesyl diphosphate <=> (+)-endo-beta-bergamotene + diphosphate","pmd":177.943}
{"X":6160,"KEGG":"R09610","RHEA_ID":28642,"DIRECTION":"BI","MASTER_ID":28639,"compounds":"(2Z,6E)-farnesyl diphosphate <=> (-)-gamma-cadinene + diphosphate","pmd":177.943}
{"X":6161,"KEGG":"R09611","RHEA_ID":32350,"DIRECTION":"BI","MASTER_ID":32347,"compounds":"2 S-adenosyl-L-methionine + tricetin <=> 3',5'-di-O-methyltricetin + 2 H(+) + 2 S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6162,"KEGG":"R09611","RHEA_ID":32350,"DIRECTION":"BI","MASTER_ID":32347,"compounds":"2 S-adenosyl-L-methionine + tricetin <=> 3',5'-di-O-methyltricetin + 2 H(+) + 2 S-adenosyl-L-homocysteine","pmd":28.031}
{"X":6163,"KEGG":"R09612","RHEA_ID":27496,"DIRECTION":"BI","MASTER_ID":27493,"compounds":"S-adenosyl-L-methionine + tricetin <=> 3'-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6164,"KEGG":"R09612","RHEA_ID":32354,"DIRECTION":"BI","MASTER_ID":32351,"compounds":"3 S-adenosyl-L-methionine + tricetin <=> 3',4',5'-O-trimethyltricetin + 3 H(+) + 3 S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6165,"KEGG":"R09613","RHEA_ID":27500,"DIRECTION":"BI","MASTER_ID":27497,"compounds":"3'-O-methyltricetin + S-adenosyl-L-methionine <=> 3',5'-di-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6166,"KEGG":"R09614","RHEA_ID":29502,"DIRECTION":"BI","MASTER_ID":29499,"compounds":"(2E,6E)-farnesyl diphosphate <=> (+)-alpha-barbatene + diphosphate","pmd":177.943}
{"X":6167,"KEGG":"R09615","RHEA_ID":29478,"DIRECTION":"BI","MASTER_ID":29475,"compounds":"(2E,6E)-farnesyl diphosphate <=> (+)-cubenene + diphosphate","pmd":177.943}
{"X":6168,"KEGG":"R09616","RHEA_ID":30426,"DIRECTION":"BI","MASTER_ID":30423,"compounds":"(2E,6E)-farnesyl diphosphate <=> (+)-delta-selinene + diphosphate","pmd":177.943}
{"X":6169,"KEGG":"R09617","RHEA_ID":29482,"DIRECTION":"BI","MASTER_ID":29479,"compounds":"(2E,6E)-farnesyl diphosphate + H2O <=> (+)-epicubenol + diphosphate","pmd":159.933}
{"X":6170,"KEGG":"R09618","RHEA_ID":27537,"DIRECTION":"BI","MASTER_ID":27534,"compounds":"(2E,6E)-farnesyl diphosphate + H2O <=> (3R,6E)-nerolidol + diphosphate","pmd":159.933}
{"X":6171,"KEGG":"R09619","RHEA_ID":28301,"DIRECTION":"BI","MASTER_ID":28298,"compounds":"(2E,6E)-farnesyl diphosphate <=> (E)-gamma-bisabolene + diphosphate","pmd":177.943}
{"X":6172,"KEGG":"R09620","RHEA_ID":26084,"DIRECTION":"BI","MASTER_ID":26081,"compounds":"(2E,6E)-farnesyl diphosphate <=> (Z)-gamma-bisabolene + diphosphate","pmd":177.943}
{"X":6173,"KEGG":"R09621","RHEA_ID":22295,"DIRECTION":"BI","MASTER_ID":22292,"compounds":"benzoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> biphenyl-3,5-diol + 4 CO2 + 4 CoA","pmd":86}
{"X":6174,"KEGG":"R09621","RHEA_ID":22295,"DIRECTION":"BI","MASTER_ID":22292,"compounds":"benzoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> biphenyl-3,5-diol + 4 CO2 + 4 CoA","pmd":104.026}
{"X":6175,"KEGG":"R09624","RHEA_ID":28305,"DIRECTION":"BI","MASTER_ID":28302,"compounds":"(2E,6E)-farnesyl diphosphate <=> diphosphate + germacrene C","pmd":177.943}
{"X":6176,"KEGG":"R09625","RHEA_ID":28285,"DIRECTION":"BI","MASTER_ID":28282,"compounds":"(S)-beta-bisabolene <=> (S)-beta-macrocarpene","pmd":0}
{"X":6177,"KEGG":"R09626","RHEA_ID":29490,"DIRECTION":"BI","MASTER_ID":29487,"compounds":"(2E,6E)-farnesyl diphosphate <=> cis-muurola-3,5-diene + diphosphate","pmd":177.943}
{"X":6178,"KEGG":"R09627","RHEA_ID":29494,"DIRECTION":"BI","MASTER_ID":29491,"compounds":"(2E,6E)-farnesyl diphosphate <=> cis-muurola-4(14),5-diene + diphosphate","pmd":177.943}
{"X":6179,"KEGG":"R09628","RHEA_ID":28293,"DIRECTION":"BI","MASTER_ID":28290,"compounds":"(2E,6E)-farnesyl diphosphate + H2O <=> (5S,9S,10S)-drim-7-en-11-ol + diphosphate","pmd":159.933}
{"X":6180,"KEGG":"R09629","RHEA_ID":29506,"DIRECTION":"BI","MASTER_ID":29503,"compounds":"(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + patchoulol","pmd":159.933}
{"X":6181,"KEGG":"R09630","RHEA_ID":27957,"DIRECTION":"BI","MASTER_ID":27954,"compounds":"(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + presilphiperfolan-8beta-ol","pmd":159.933}
{"X":6182,"KEGG":"R09631","RHEA_ID":28257,"DIRECTION":"BI","MASTER_ID":28254,"compounds":"(3Z)-hex-3-en-1-ol + acetyl-CoA <=> (3Z)-hex-3-en-1-yl acetate + CoA","pmd":42.011}
{"X":6183,"KEGG":"R09632","RHEA_ID":26477,"DIRECTION":"BI","MASTER_ID":26474,"metacyc":"RXN-10755","compounds":"beta-D-galactosyl-(1->4)-L-rhamnose + phosphate <=> alpha-D-galactose 1-phosphate + L-rhamnopyranose","pmd":66.092}
{"X":6184,"KEGG":"R09633","RHEA_ID":27813,"DIRECTION":"BI","MASTER_ID":27810,"compounds":"dimethylallyl diphosphate + 2 isopentenyl diphosphate <=> (2Z,6Z)-farnesyl diphosphate + 2 diphosphate","pmd":136.125}
{"X":6185,"KEGG":"R09634","RHEA_ID":26191,"DIRECTION":"BI","MASTER_ID":26188,"compounds":"1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine <=> 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H(+) + UDP","pmd":143.973}
{"X":6186,"KEGG":"R09634","RHEA_ID":26191,"DIRECTION":"BI","MASTER_ID":26188,"compounds":"1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine <=> 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H(+) + UDP","pmd":143.972}
{"X":6187,"KEGG":"R09635","RHEA_ID":28261,"DIRECTION":"BI","MASTER_ID":28258,"metacyc":"RXN-11756","compounds":"cyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucuronate <=> cyanidin 3-O-(2-O-beta-D-glucuronosyl)-beta-D-glucoside + H(+) + UDP","pmd":45.106}
{"X":6188,"KEGG":"R09636","RHEA_ID":31478,"DIRECTION":"BI","MASTER_ID":31475,"compounds":"soyasapogenol B + UDP-alpha-D-glucuronate <=> H(+) + soyasapogenol B 3-O-beta-D-glucuronate + UDP","pmd":54.374}
{"X":6189,"KEGG":"R09637","RHEA_ID":16664,"DIRECTION":"BI","MASTER_ID":16661,"compounds":"fluoride + S-adenosyl-L-methionine <=> 5'-deoxy-5'-fluoroadenosine + L-methionine","pmd":129.045}
{"X":6190,"KEGG":"R09638","RHEA_ID":30566,"DIRECTION":"BI","MASTER_ID":30563,"metacyc":"RXN-11191","compounds":"dimethylallyl diphosphate + L-tryptophan <=> 7-(3-methylbut-2-enyl)-L-tryptophan + diphosphate","pmd":68.063}
{"X":6191,"KEGG":"R09638","RHEA_ID":30566,"DIRECTION":"BI","MASTER_ID":30563,"metacyc":"RXN-11191","compounds":"dimethylallyl diphosphate + L-tryptophan <=> 7-(3-methylbut-2-enyl)-L-tryptophan + diphosphate","pmd":26.147}
{"X":6192,"KEGG":"R09639","RHEA_ID":28113,"DIRECTION":"BI","MASTER_ID":28110,"metacyc":"RXN-11714","compounds":"chloride + S-adenosyl-L-methionine <=> 5'-chloro-5'-deoxyadenosine + L-methionine","pmd":113.074}
{"X":6193,"KEGG":"R09642","RHEA_ID":28265,"DIRECTION":"BI","MASTER_ID":28262,"metacyc":"RXN-11812","compounds":"3-alpha-D-mannopyranosyl-alpha-D-mannopyranose + UDP-alpha-D-xylose <=> 3-O-(6-O-alpha-D-xylosylphospho-alpha-D-mannopyranosyl)-alpha-D-mannopyranose + H(+) + UMP","pmd":18.08}
{"X":6194,"KEGG":"R09643","RHEA_ID":28545,"DIRECTION":"BI","MASTER_ID":28542,"compounds":"fluoroacetyl-CoA + H2O <=> CoA + fluoroacetate + H(+)","pmd":60.001}
{"X":6195,"KEGG":"R09646","RHEA_ID":18940,"DIRECTION":"BI","MASTER_ID":18937,"compounds":"an N-acyl-L-homoserine lactone + H2O <=> a carboxylate + L-homoserine lactone"}
{"X":6196,"KEGG":"R09647","RHEA_ID":26545,"DIRECTION":"BI","MASTER_ID":26542,"metacyc":"RXN-13715","compounds":"(R)-piperazine-2-carboxamide + H2O <=> (R)-piperazine-2-carboxylate + NH4(+)","pmd":0.984}
{"X":6197,"KEGG":"R09648","RHEA_ID":26549,"DIRECTION":"BI","MASTER_ID":26546,"metacyc":"RXN-10760","compounds":"beta-alaninamide + H2O <=> beta-alanine + NH4(+)"}
{"X":6198,"KEGG":"R09649","RHEA_ID":26553,"DIRECTION":"BI","MASTER_ID":26550,"metacyc":"RXN-13714","compounds":"(S)-piperazine-2-carboxamide + H2O <=> (S)-piperazine-2-carboxylate + NH4(+)","pmd":0.984}
{"X":6199,"KEGG":"R09650","RHEA_ID":26513,"DIRECTION":"BI","MASTER_ID":26510,"metacyc":"RXN-10758","compounds":"H2O + L-prolinamide <=> L-proline + NH4(+)","pmd":0.984}
{"X":6200,"KEGG":"R09651","RHEA_ID":26183,"DIRECTION":"BI","MASTER_ID":26180,"compounds":"1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O <=> 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate","pmd":42.011}
{"X":6201,"KEGG":"R09652","RHEA_ID":30290,"DIRECTION":"BI","MASTER_ID":30287,"compounds":"15-cis-phytoene + 2 a plastoquinone <=> 9,9',15-tri-cis-zeta-carotene + 2 a plastoquinol","pmd":4.031}
{"X":6202,"KEGG":"R09653","RHEA_ID":46155,"DIRECTION":"BI","MASTER_ID":46152,"compounds":"15-cis-phytoene + a plastoquinone <=> 15,9'-di-cis-phytofluene + a plastoquinol","pmd":2.016}
{"X":6203,"KEGG":"R09654","RHEA_ID":46159,"DIRECTION":"BI","MASTER_ID":46156,"compounds":"15,9'-di-cis-phytofluene + a plastoquinone <=> 9,9',15-tri-cis-zeta-carotene + a plastoquinol","pmd":2.016}
{"X":6204,"KEGG":"R09655","RHEA_ID":30970,"DIRECTION":"BI","MASTER_ID":30967,"compounds":"9,9',15-tri-cis-zeta-carotene <=> 9,9'-di-cis-zeta-carotene","pmd":0}
{"X":6205,"KEGG":"R09656","RHEA_ID":30962,"DIRECTION":"BI","MASTER_ID":30959,"compounds":"9,9'-di-cis-zeta-carotene + a quinone <=> 7,9,9'-tri-cis-neurosporene + a quinol","pmd":2.016}
{"X":6206,"KEGG":"R09657","RHEA_ID":28141,"DIRECTION":"BI","MASTER_ID":28138,"metacyc":"RXN-11751","compounds":"H2O + streptothricin F <=> streptothricin F acid","pmd":18.01}
{"X":6207,"KEGG":"R09658","RHEA_ID":30966,"DIRECTION":"BI","MASTER_ID":30963,"compounds":"7,9,9'-tri-cis-neurosporene + a quinone <=> 7,7',9,9'-tetra-cis-lycopene + a quinol","pmd":2.016}
{"X":6208,"KEGG":"R09659","RHEA_ID":30622,"DIRECTION":"BI","MASTER_ID":30619,"metacyc":"RXN-12411","compounds":"2 A + all-trans-zeta-carotene <=> 2 AH2 + all-trans-lycopene","pmd":4.031}
{"X":6209,"KEGG":"R09661","RHEA_ID":28169,"DIRECTION":"BI","MASTER_ID":28166,"compounds":"5-nitroanthranilate + H(+) + H2O <=> 5-nitrosalicylate + NH4(+)","pmd":0.984}
{"X":6210,"KEGG":"R09662","RHEA_ID":31306,"DIRECTION":"BI","MASTER_ID":31303,"metacyc":"RXN-12446","compounds":"a reduced flavin + NAD(+) <=> an oxidized flavin + 2 H(+) + NADH"}
{"X":6211,"KEGG":"R09663","RHEA_ID":47247,"DIRECTION":"BI","MASTER_ID":47244,"metacyc":"RXN-8851","compounds":"(2R)-3-phosphoglycerate + an NDP-alpha-D-glucose <=> (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + a ribonucleoside 5'-diphosphate + H(+)","pmd":162.053}
{"X":6212,"KEGG":"R09664","RHEA_ID":31346,"DIRECTION":"BI","MASTER_ID":31343,"compounds":"(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H2O <=> (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate","pmd":79.966}
{"X":6213,"KEGG":"R09665","RHEA_ID":30926,"DIRECTION":"BI","MASTER_ID":30923,"compounds":"(R)-glycerate + ADP-alpha-D-glucose <=> (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + ADP + H(+)","pmd":162.053}
{"X":6214,"KEGG":"R09666","RHEA_ID":30642,"DIRECTION":"BI","MASTER_ID":30639,"compounds":"(R)-glycerate + GDP-alpha-D-mannose <=> (2R)-2-O-(alpha-D-mannosyl)-glycerate + GDP + H(+)","pmd":162.053}
{"X":6215,"KEGG":"R09667","RHEA_ID":31326,"DIRECTION":"BI","MASTER_ID":31323,"compounds":"(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP-alpha-D-mannose <=> (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + GDP + H(+)","pmd":94.979}
{"X":6216,"KEGG":"R09667","RHEA_ID":31326,"DIRECTION":"BI","MASTER_ID":31323,"compounds":"(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP-alpha-D-mannose <=> (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + GDP + H(+)","pmd":94.978}
{"X":6217,"KEGG":"R09668","RHEA_ID":30646,"DIRECTION":"BI","MASTER_ID":30643,"compounds":"phosphate + S-methyl-5'-thioinosine <=> hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate","pmd":38.062}
{"X":6218,"KEGG":"R09669","RHEA_ID":30650,"DIRECTION":"BI","MASTER_ID":30647,"compounds":"1D-myo-inositol 3-phosphate + CTP + H(+) <=> CDP-1L-myo-inositol + diphosphate","pmd":305.041}
{"X":6219,"KEGG":"R09669","RHEA_ID":30650,"DIRECTION":"BI","MASTER_ID":30647,"compounds":"1D-myo-inositol 3-phosphate + CTP + H(+) <=> CDP-1L-myo-inositol + diphosphate","pmd":82.087}
{"X":6220,"KEGG":"R09670","RHEA_ID":31330,"DIRECTION":"BI","MASTER_ID":31327,"compounds":"1D-myo-inositol 3-phosphate + CDP-1L-myo-inositol <=> bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate + CMP + H(+)","pmd":63.022}
{"X":6221,"KEGG":"R09671","RHEA_ID":31022,"DIRECTION":"BI","MASTER_ID":31019,"compounds":"4 AH2 + all-trans-4,4'-diapolycopene + 4 O2 <=> 4 A + all-trans-4,4'-diapolycopene-4,4'-dial + 6 H2O","pmd":27.959}
{"X":6222,"KEGG":"R09672","RHEA_ID":48879,"DIRECTION":"BI","MASTER_ID":48876,"compounds":"3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H2O <=> L-seryl-[protein] + N-acetyl-D-glucosamine"}
{"X":6223,"KEGG":"R09673","RHEA_ID":48895,"DIRECTION":"BI","MASTER_ID":48892,"compounds":"3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H2O <=> L-threonyl-[protein] + N-acetyl-D-glucosamine"}
{"X":6224,"KEGG":"R09674","RHEA_ID":30366,"DIRECTION":"BI","MASTER_ID":30363,"compounds":"fumonisin B1 + 2 H2O <=> (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + 2 H(+) + 2 tricarballylate","pmd":316.043}
{"X":6225,"KEGG":"R09676","RHEA_ID":48907,"DIRECTION":"BI","MASTER_ID":48904,"metacyc":"RXN-11889","compounds":"L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H(+) + UDP","pmd":203.079}
{"X":6226,"KEGG":"R09677","RHEA_ID":48911,"DIRECTION":"BI","MASTER_ID":48908,"metacyc":"RXN-11890","compounds":"L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP","pmd":203.079}
{"X":6227,"KEGG":"R09678","RHEA_ID":27504,"DIRECTION":"BI","MASTER_ID":27501,"compounds":"3',5'-di-O-methyltricetin + S-adenosyl-L-methionine <=> 3',4',5'-O-trimethyltricetin + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6228,"KEGG":"R09681","RHEA_ID":25547,"DIRECTION":"BI","MASTER_ID":25544,"compounds":"ent-copalyl diphosphate <=> diphosphate + ent-pimara-9(11),15-diene","pmd":177.943}
{"X":6229,"KEGG":"R09682","RHEA_ID":23331,"DIRECTION":"BI","MASTER_ID":23328,"compounds":"a 9-cis-epoxycarotenoid + O2 <=> 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal"}
{"X":6230,"KEGG":"R09683","RHEA_ID":27945,"DIRECTION":"BI","MASTER_ID":27942,"metacyc":"RXN-11767","compounds":"(3R)-3-hydroxy-D-aspartate <=> NH4(+) + oxaloacetate","pmd":17.026}
{"X":6231,"KEGG":"R09684","RHEA_ID":25620,"DIRECTION":"BI","MASTER_ID":25617,"compounds":"terpentedienyl diphosphate <=> diphosphate + terpentetriene","pmd":177.943}
{"X":6232,"KEGG":"R09685","RHEA_ID":26244,"DIRECTION":"BI","MASTER_ID":26241,"compounds":"geranylgeranyl diphosphate <=> diphosphate + elisabethatriene","pmd":177.943}
{"X":6233,"KEGG":"R09686","RHEA_ID":26433,"DIRECTION":"BI","MASTER_ID":26430,"compounds":"(+)-copalyl diphosphate + H2O <=> diphosphate + phyllocladan-16alpha-ol","pmd":159.933}
{"X":6234,"KEGG":"R09687","RHEA_ID":27833,"DIRECTION":"BI","MASTER_ID":27830,"compounds":"neryl diphosphate <=> beta-phellandrene + diphosphate","pmd":177.943}
{"X":6235,"KEGG":"R09688","RHEA_ID":31002,"DIRECTION":"BI","MASTER_ID":30999,"compounds":"(S)-2,3-epoxysqualene <=> cucurbitadienol","pmd":0}
{"X":6236,"KEGG":"R09689","RHEA_ID":30990,"DIRECTION":"BI","MASTER_ID":30987,"metacyc":"RXN-12329","compounds":"(S)-2,3-epoxysqualene <=> (17Z)-protosta-17(20),24-dien-3beta-ol","pmd":0}
{"X":6237,"KEGG":"R09690","RHEA_ID":31394,"DIRECTION":"BI","MASTER_ID":31391,"metacyc":"RXN-12224","compounds":"15-cis-4,4'-diapophytoene + 4 FAD + 4 H(+) <=> all-trans-4,4'-diapolycopene + 4 FADH2","pmd":2.016}
{"X":6238,"KEGG":"R09690","RHEA_ID":31394,"DIRECTION":"BI","MASTER_ID":31391,"metacyc":"RXN-12224","compounds":"15-cis-4,4'-diapophytoene + 4 FAD + 4 H(+) <=> all-trans-4,4'-diapolycopene + 4 FADH2","pmd":8.063}
{"X":6239,"KEGG":"R09691","RHEA_ID":30602,"DIRECTION":"BI","MASTER_ID":30599,"metacyc":"RXN-12247","compounds":"15-cis-phytoene + 3 A <=> 3 AH2 + all-trans-neurosporene","pmd":6.047}
{"X":6240,"KEGG":"R09692","RHEA_ID":30606,"DIRECTION":"BI","MASTER_ID":30603,"compounds":"15-cis-phytoene + A <=> AH2 + all-trans-phytofluene","pmd":2.016}
{"X":6241,"KEGG":"R09693","RHEA_ID":30618,"DIRECTION":"BI","MASTER_ID":30615,"metacyc":"RXN-12410","compounds":"15-cis-phytoene + 2 A <=> 2 AH2 + all-trans-zeta-carotene","pmd":4.031}
{"X":6242,"KEGG":"R09694","RHEA_ID":15728,"DIRECTION":"BI","MASTER_ID":15725,"compounds":"1,5-anhydro-D-fructose <=> ascopyrone M + H2O","pmd":18.01}
{"X":6243,"KEGG":"R09695","RHEA_ID":13748,"DIRECTION":"BI","MASTER_ID":13745,"compounds":"ascopyrone M <=> microthecin","pmd":0}
{"X":6244,"KEGG":"R09696","RHEA_ID":12103,"DIRECTION":"BI","MASTER_ID":12100,"metacyc":"RXN-14306","compounds":"1,5-anhydro-D-fructose <=> H2O + microthecin","pmd":18.01}
{"X":6245,"KEGG":"R09697","RHEA_ID":26114,"DIRECTION":"BI","MASTER_ID":26111,"compounds":"UDP-N-acetyl-alpha-D-glucosamine <=> H2O + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose","pmd":18.011}
{"X":6246,"KEGG":"R09698","RHEA_ID":26529,"DIRECTION":"BI","MASTER_ID":26526,"metacyc":"RXN-7699","compounds":"a (3R)-hydroxyacyl-CoA <=> a (2E)-enoyl-CoA + H2O"}
{"X":6247,"KEGG":"R09699","RHEA_ID":28177,"DIRECTION":"BI","MASTER_ID":28174,"compounds":"(9S)-hydroperoxy-(10E,12Z)-octadecadienoate <=> colneleate + H2O","pmd":18.011}
{"X":6248,"KEGG":"R09700","RHEA_ID":31038,"DIRECTION":"BI","MASTER_ID":31035,"metacyc":"RXN-9684","compounds":"arabidiol <=> (S)-2,3-epoxysqualene + H2O","pmd":18.011}
{"X":6249,"KEGG":"R09701","RHEA_ID":30858,"DIRECTION":"BI","MASTER_ID":30855,"compounds":"dammarenediol-II <=> (S)-2,3-epoxysqualene + H2O","pmd":18.011}
{"X":6250,"KEGG":"R09702","RHEA_ID":30714,"DIRECTION":"BI","MASTER_ID":30711,"compounds":"(S)-linalool <=> beta-myrcene + H2O","pmd":18.011}
{"X":6251,"KEGG":"R09703","RHEA_ID":30978,"DIRECTION":"BI","MASTER_ID":30975,"metacyc":"RXN-12413","compounds":"15-cis-phytoene + 5 A <=> 5 AH2 + all-trans-3,4-didehydrolycopene","pmd":10.078}
{"X":6252,"KEGG":"R09704","RHEA_ID":46627,"DIRECTION":"BI","MASTER_ID":46624,"metacyc":"RXN-9781","compounds":"a D-5-monosubstituted hydantoin <=> a L-5-monosubstituted hydantoin"}
{"X":6253,"KEGG":"R09705","RHEA_ID":22571,"DIRECTION":"BI","MASTER_ID":22568,"compounds":"ascopyrone M <=> ascopyrone P","pmd":0}
{"X":6254,"KEGG":"R09707","RHEA_ID":28185,"DIRECTION":"BI","MASTER_ID":28182,"compounds":"(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate <=> (1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate","pmd":0}
{"X":6255,"KEGG":"R09708","RHEA_ID":30718,"DIRECTION":"BI","MASTER_ID":30715,"metacyc":"RXN-12336","compounds":"geraniol <=> (S)-linalool","pmd":0}
{"X":6256,"KEGG":"R09709","RHEA_ID":26163,"DIRECTION":"BI","MASTER_ID":26160,"compounds":"(S)-2,3-epoxysqualene <=> thalianol","pmd":0}
{"X":6257,"KEGG":"R09710","RHEA_ID":31006,"DIRECTION":"BI","MASTER_ID":31003,"metacyc":"RXN-9915","compounds":"(S)-2,3-epoxysqualene <=> germanicol","pmd":0}
{"X":6258,"KEGG":"R09711","RHEA_ID":30454,"DIRECTION":"BI","MASTER_ID":30451,"metacyc":"RXN-12103","compounds":"(S)-2,3-epoxysqualene <=> isomultiflorenol","pmd":0}
{"X":6259,"KEGG":"R09712","RHEA_ID":31026,"DIRECTION":"BI","MASTER_ID":31023,"compounds":"squalene <=> dammara-20,24-diene","pmd":0}
{"X":6260,"KEGG":"R09713","RHEA_ID":31014,"DIRECTION":"BI","MASTER_ID":31011,"metacyc":"RXN-12330","compounds":"(S)-2,3-epoxysqualene <=> camelliol C","pmd":0}
{"X":6261,"KEGG":"R09714","RHEA_ID":25616,"DIRECTION":"BI","MASTER_ID":25613,"compounds":"all-trans-geranylgeranyl diphosphate <=> terpentedienyl diphosphate","pmd":0}
{"X":6262,"KEGG":"R09715","RHEA_ID":25624,"DIRECTION":"BI","MASTER_ID":25621,"compounds":"geranylgeranyl diphosphate <=> tuberculosinyl diphosphate","pmd":0}
{"X":6263,"KEGG":"R09716","RHEA_ID":15588,"DIRECTION":"BI","MASTER_ID":15585,"metacyc":"RXN-12414","compounds":"15-cis-phytoene + 4 A <=> 4 AH2 + all-trans-lycopene","pmd":8.063}
{"X":6264,"KEGG":"R09717","RHEA_ID":27937,"DIRECTION":"BI","MASTER_ID":27934,"metacyc":"RXN-11768","compounds":"(3S)-3-hydroxy-D-aspartate <=> glycine + glyoxylate"}
{"X":6265,"KEGG":"R09717","RHEA_ID":27941,"DIRECTION":"BI","MASTER_ID":27938,"metacyc":"3-HYDROXYASPARTATE-ALDOLASE-RXN","compounds":"(3R)-3-hydroxy-D-aspartate <=> glycine + glyoxylate"}
{"X":6266,"KEGG":"R09719","RHEA_ID":31398,"DIRECTION":"BI","MASTER_ID":31395,"compounds":"15-cis-4,4'-diapophytoene + FAD + H(+) <=> all-trans-4,4'-diapophytofluene + FADH2","pmd":2.016}
{"X":6267,"KEGG":"R09720","RHEA_ID":32306,"DIRECTION":"BI","MASTER_ID":32303,"metacyc":"RXN-13722","compounds":"(2R)-homocitrate <=> (1R,2S)-homoisocitrate","pmd":0}
{"X":6268,"KEGG":"R09722","RHEA_ID":12848,"DIRECTION":"BI","MASTER_ID":12845,"compounds":"[L-4-(L-arginin-2-N-yl)aspartate](n) + H2O <=> [L-4-(L-arginin-2-N-yl)aspartate](n-1) + L-4-(L-arginin-2-N-yl)aspartate"}
{"X":6269,"KEGG":"R09723","RHEA_ID":31350,"DIRECTION":"BI","MASTER_ID":31347,"compounds":"(+)-abscisic acid D-glucopyranosyl ester + H2O <=> 2-cis-(+)-abscisate + beta-D-glucose + H(+)","pmd":162.053}
{"X":6270,"KEGG":"R09724","RHEA_ID":30286,"DIRECTION":"BI","MASTER_ID":30283,"compounds":"(-)-trans-permethrin + H2O <=> (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + (3-phenoxyphenyl)methanol + H(+)","pmd":182.073}
{"X":6271,"KEGG":"R09725","RHEA_ID":42703,"DIRECTION":"BI","MASTER_ID":42700,"compounds":"6-carboxyhexanoyl-[ACP] methyl ester + H2O <=> 6-carboxyhexanoyl-[ACP] + H(+) + methanol"}
{"X":6272,"KEGG":"R09727","RHEA_ID":56107,"DIRECTION":"BI","MASTER_ID":56104,"compounds":"2 AH2 + all-trans-4,4'-diaponeurosporene + 2 O2 <=> 4,4'-diaponeurosporenal + 2 A + 3 H2O","pmd":13.979}
{"X":6273,"KEGG":"R09729","RHEA_ID":26067,"DIRECTION":"BI","MASTER_ID":26064,"metacyc":"RXN-10030","compounds":"ATP + hygromycin B <=> 4-O-phosphohygromycin B + ADP + H(+)","pmd":79.966}
{"X":6274,"KEGG":"R09730","RHEA_ID":27625,"DIRECTION":"BI","MASTER_ID":27622,"metacyc":"RXN-11488","compounds":"geranylgeranyl diphosphate + 7 isopentenyl diphosphate <=> 7 diphosphate + tri-trans,hepta-cis-undecaprenyl diphosphate","pmd":476.438}
{"X":6275,"KEGG":"R09730","RHEA_ID":27625,"DIRECTION":"BI","MASTER_ID":27622,"metacyc":"RXN-11488","compounds":"geranylgeranyl diphosphate + 7 isopentenyl diphosphate <=> 7 diphosphate + tri-trans,hepta-cis-undecaprenyl diphosphate","pmd":680.626}
{"X":6276,"KEGG":"R09732","RHEA_ID":30634,"DIRECTION":"BI","MASTER_ID":30631,"compounds":"alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-diphospho-di-trans,octa-cis-undecaprenol + UDP-alpha-D-glucuronate <=> beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-diphospho-di-trans,octa-cis-undecaprenol + H(+) + UDP","pmd":176.032}
{"X":6277,"KEGG":"R09733","RHEA_ID":28313,"DIRECTION":"BI","MASTER_ID":28310,"compounds":"beta-D-Glc-(1->4)-alpha-D-Glc-1-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose <=> alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)","pmd":162.053}
{"X":6278,"KEGG":"R09734","RHEA_ID":28309,"DIRECTION":"BI","MASTER_ID":28306,"compounds":"beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose <=> beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)","pmd":162.053}
{"X":6279,"KEGG":"R09735","RHEA_ID":35050,"DIRECTION":"BI","MASTER_ID":35047,"compounds":"adenylyl-molybdopterin + H(+) + molybdate <=> AMP + H2O + Mo-molybdopterin","pmd":201.173}
{"X":6280,"KEGG":"R09736","RHEA_ID":42643,"DIRECTION":"BI","MASTER_ID":42640,"compounds":"a 2-demethylmenaquinol + S-adenosyl-L-methionine <=> a menaquinol + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6281,"KEGG":"R09737","RHEA_ID":28289,"DIRECTION":"BI","MASTER_ID":28286,"compounds":"a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine <=> a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6282,"KEGG":"R09738","RHEA_ID":27909,"DIRECTION":"BI","MASTER_ID":27906,"compounds":"butanoyl-CoA + NADP(+) <=> (2E)-butenoyl-CoA + H(+) + NADPH","pmd":91.058}
{"X":6283,"KEGG":"R09738","RHEA_ID":27909,"DIRECTION":"BI","MASTER_ID":27906,"compounds":"butanoyl-CoA + NADP(+) <=> (2E)-butenoyl-CoA + H(+) + NADPH","pmd":2.016}
{"X":6284,"KEGG":"R09740","RHEA_ID":48363,"DIRECTION":"BI","MASTER_ID":48360,"metacyc":"RXN-11820","compounds":"a 1,2-saturated fatty acid + H2O2 <=> a 2-hydroxy fatty acid + H2O"}
{"X":6285,"KEGG":"R09741","RHEA_ID":48387,"DIRECTION":"BI","MASTER_ID":48384,"metacyc":"RXN-11820","compounds":"2,3-saturated fatty acid + H2O2 <=> 3-hydroxy fatty acid + H2O"}
{"X":6286,"KEGG":"R09743","RHEA_ID":31354,"DIRECTION":"BI","MASTER_ID":31351,"compounds":"lupan-3beta,20-diol <=> (S)-2,3-epoxysqualene + H2O","pmd":18.011}
{"X":6287,"KEGG":"R09744","RHEA_ID":31402,"DIRECTION":"BI","MASTER_ID":31399,"compounds":"all-trans-4,4'-diapophytofluene + FAD + H(+) <=> all-trans-4,4'-diapo-zeta-carotene + FADH2","pmd":2.016}
{"X":6288,"KEGG":"R09745","RHEA_ID":31406,"DIRECTION":"BI","MASTER_ID":31403,"compounds":"all-trans-4,4'-diapo-zeta-carotene + FAD + H(+) <=> all-trans-4,4'-diaponeurosporene + FADH2","pmd":2.016}
{"X":6289,"KEGG":"R09746","RHEA_ID":31410,"DIRECTION":"BI","MASTER_ID":31407,"compounds":"all-trans-4,4'-diaponeurosporene + FAD + H(+) <=> all-trans-4,4'-diapolycopene + FADH2","pmd":2.016}
{"X":6290,"KEGG":"R09747","RHEA_ID":30334,"DIRECTION":"BI","MASTER_ID":30331,"compounds":"all-trans-beta-carotene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> all-trans-zeaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]","pmd":31.99}
{"X":6291,"KEGG":"R09748","RHEA_ID":30150,"DIRECTION":"BI","MASTER_ID":30147,"metacyc":"RXN-13750","compounds":"FADH2 + NAD(+) <=> FAD + 2 H(+) + NADH","pmd":2.016}
{"X":6292,"KEGG":"R09748","RHEA_ID":30150,"DIRECTION":"BI","MASTER_ID":30147,"metacyc":"RXN-13750","compounds":"FADH2 + NAD(+) <=> FAD + 2 H(+) + NADH","pmd":121.04}
{"X":6293,"KEGG":"R09749","RHEA_ID":31366,"DIRECTION":"BI","MASTER_ID":31363,"metacyc":"RXN-12450","compounds":"NADP(+) + reduced coenzyme F420-(gamma-Glu)(n) <=> 2 H(+) + NADPH + oxidized coenzyme F420-(gamma-Glu)(n)","pmd":29.096}
{"X":6294,"KEGG":"R09749","RHEA_ID":31366,"DIRECTION":"BI","MASTER_ID":31363,"metacyc":"RXN-12450","compounds":"NADP(+) + reduced coenzyme F420-(gamma-Glu)(n) <=> 2 H(+) + NADPH + oxidized coenzyme F420-(gamma-Glu)(n)","pmd":2.016}
{"X":6295,"KEGG":"R09750","RHEA_ID":31458,"DIRECTION":"BI","MASTER_ID":31455,"compounds":"NAD(+) + reduced riboflavin <=> 2 H(+) + NADH + riboflavin","pmd":2.016}
{"X":6296,"KEGG":"R09750","RHEA_ID":31458,"DIRECTION":"BI","MASTER_ID":31455,"compounds":"NAD(+) + reduced riboflavin <=> 2 H(+) + NADH + riboflavin","pmd":287.979}
{"X":6297,"KEGG":"R09751","RHEA_ID":31370,"DIRECTION":"BI","MASTER_ID":31367,"metacyc":"RXN-12316","compounds":"2 H(+) + 3 nitrite <=> H2O + nitrate + 2 nitric oxide"}
{"X":6298,"KEGG":"R09752","RHEA_ID":30390,"DIRECTION":"BI","MASTER_ID":30387,"metacyc":"RXN-12486","compounds":"GDP-alpha-D-glucose + phosphate <=> alpha-D-glucose 1-phosphate + GDP + H(+)","pmd":162.053}
{"X":6299,"KEGG":"R09753","RHEA_ID":31490,"DIRECTION":"BI","MASTER_ID":31487,"compounds":"soyasapogenol B 3-O-beta-D-glucuronate + UDP-alpha-D-galactose <=> H(+) + soyasaponin III + UDP","pmd":162.053}
{"X":6300,"KEGG":"R09754","RHEA_ID":31494,"DIRECTION":"BI","MASTER_ID":31491,"compounds":"soyasaponin III + UDP-beta-L-rhamnose <=> H(+) + soyasaponin I + UDP","pmd":146.058}
{"X":6301,"KEGG":"R09755","RHEA_ID":31502,"DIRECTION":"BI","MASTER_ID":31499,"metacyc":"RXN-12113","compounds":"a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose <=> a neolactoside nLc4Cer(d18:1(4E)) + H(+) + UDP","pmd":162.053}
{"X":6302,"KEGG":"R09756","RHEA_ID":35694,"DIRECTION":"BI","MASTER_ID":35691,"compounds":"(2S)-versicolorone + NADP(+) <=> 1'-hydroxyversicolorone + H(+) + NADPH","pmd":2.016}
{"X":6303,"KEGG":"R09756","RHEA_ID":35694,"DIRECTION":"BI","MASTER_ID":35691,"compounds":"(2S)-versicolorone + NADP(+) <=> 1'-hydroxyversicolorone + H(+) + NADPH","pmd":359.999}
{"X":6304,"KEGG":"R09757","RHEA_ID":31466,"DIRECTION":"BI","MASTER_ID":31463,"compounds":"crocetin + UDP-alpha-D-glucose <=> beta-D-glucosyl crocetin + UDP","pmd":75.835}
{"X":6305,"KEGG":"R09758","RHEA_ID":31470,"DIRECTION":"BI","MASTER_ID":31467,"compounds":"beta-D-glucosyl crocetin + UDP-alpha-D-glucose <=> bis(beta-D-glucosyl) crocetin + UDP","pmd":86.218}
{"X":6306,"KEGG":"R09759","RHEA_ID":31474,"DIRECTION":"BI","MASTER_ID":31471,"compounds":"beta-D-gentiobiosyl crocetin + UDP-alpha-D-glucose <=> beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP","pmd":162.053}
{"X":6307,"KEGG":"R09760","RHEA_ID":31506,"DIRECTION":"BI","MASTER_ID":31503,"compounds":"beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-diphospho-di-trans,octa-cis-undecaprenol + phosphoenolpyruvate <=> 4,6-Me(COOH)C-beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-diphospho-di-trans,octa-cis-undecaprenol + phosphate"}
{"X":6308,"KEGG":"R09763","RHEA_ID":28157,"DIRECTION":"BI","MASTER_ID":28154,"compounds":"alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate <=> alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)","pmd":220.058}
{"X":6309,"KEGG":"R09764","RHEA_ID":28157,"DIRECTION":"BI","MASTER_ID":28154,"compounds":"alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate <=> alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)"}
{"X":6310,"KEGG":"R09765","RHEA_ID":28161,"DIRECTION":"BI","MASTER_ID":28158,"compounds":"alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate <=> alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)","pmd":220.058}
{"X":6311,"KEGG":"R09766","RHEA_ID":28161,"DIRECTION":"BI","MASTER_ID":28158,"compounds":"alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate <=> alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)"}
{"X":6312,"KEGG":"R09768","RHEA_ID":27492,"DIRECTION":"BI","MASTER_ID":27489,"compounds":"2 D-sedoheptulose 7-phosphate <=> D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate","pmd":0}
{"X":6313,"KEGG":"R09770","RHEA_ID":27573,"DIRECTION":"BI","MASTER_ID":27570,"compounds":"ATP + D-glycero-alpha-D-manno-heptose 7-phosphate <=> ADP + D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H(+)","pmd":79.966}
{"X":6314,"KEGG":"R09771","RHEA_ID":28525,"DIRECTION":"BI","MASTER_ID":28522,"compounds":"D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H2O <=> D-glycero-alpha-D-manno-heptose 1-phosphate + phosphate","pmd":79.966}
{"X":6315,"KEGG":"R09772","RHEA_ID":27464,"DIRECTION":"BI","MASTER_ID":27461,"compounds":"D-glycero-alpha-D-manno-heptose 1-phosphate + GTP + H(+) <=> diphosphate + GDP-D-glycero-alpha-D-manno-heptose","pmd":345.047}
{"X":6316,"KEGG":"R09772","RHEA_ID":27464,"DIRECTION":"BI","MASTER_ID":27461,"compounds":"D-glycero-alpha-D-manno-heptose 1-phosphate + GTP + H(+) <=> diphosphate + GDP-D-glycero-alpha-D-manno-heptose","pmd":112.097}
{"X":6317,"KEGG":"R09775","RHEA_ID":41943,"DIRECTION":"BI","MASTER_ID":41940,"compounds":"[amino group carrier protein]-C-terminal-L-glutamate + ATP + L-2-aminoadipate <=> [amino group carrier protein]-C-terminal-N-(1,5-dicarboxypentan-1-yl)-L-glutamine + ADP + H(+) + phosphate","pmd":265.961}
{"X":6318,"KEGG":"R09775","RHEA_ID":41943,"DIRECTION":"BI","MASTER_ID":41940,"compounds":"[amino group carrier protein]-C-terminal-L-glutamate + ATP + L-2-aminoadipate <=> [amino group carrier protein]-C-terminal-N-(1,5-dicarboxypentan-1-yl)-L-glutamine + ADP + H(+) + phosphate","pmd":79.966}
{"X":6319,"KEGG":"R09776","RHEA_ID":41947,"DIRECTION":"BI","MASTER_ID":41944,"compounds":"[amino group carrier protein]-C-terminal-N-(1,5-dicarboxypentan-1-yl)-L-glutamine + ATP <=> [amino group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + ADP","pmd":79.966}
{"X":6320,"KEGG":"R09777","RHEA_ID":41951,"DIRECTION":"BI","MASTER_ID":41948,"compounds":"[amino group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + NADP(+) + phosphate <=> [amino group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + H(+) + NADPH"}
{"X":6321,"KEGG":"R09778","RHEA_ID":41955,"DIRECTION":"BI","MASTER_ID":41952,"metacyc":"RXN-5184","compounds":"2-oxoglutarate + [amino group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate <=> [amino group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamate","pmd":1.032}
{"X":6322,"KEGG":"R09779","RHEA_ID":48687,"DIRECTION":"BI","MASTER_ID":48684,"compounds":"[amino group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O <=> [amino group carrier protein]-C-terminal-L-glutamate + L-lysine"}
{"X":6323,"KEGG":"R09782","RHEA_ID":31522,"DIRECTION":"BI","MASTER_ID":31519,"compounds":"O2 + torulene <=> 3-methyl-2-butenal + 4'-apo-beta-carotenal","pmd":52.068}
{"X":6324,"KEGG":"R09783","RHEA_ID":31518,"DIRECTION":"BI","MASTER_ID":31515,"compounds":"4'-apo-beta-carotenal + H2O + NAD(+) <=> 2 H(+) + NADH + neurosporaxanthin","pmd":165.767}
{"X":6325,"KEGG":"R09783","RHEA_ID":31518,"DIRECTION":"BI","MASTER_ID":31515,"compounds":"4'-apo-beta-carotenal + H2O + NAD(+) <=> 2 H(+) + NADH + neurosporaxanthin","pmd":15.995}
{"X":6326,"KEGG":"R09784","RHEA_ID":31526,"DIRECTION":"BI","MASTER_ID":31523,"compounds":"2-oxoglutarate + 2 H(+) + O2 <=> 3 CO2 + ethene + H2O"}
{"X":6327,"KEGG":"R09785","RHEA_ID":31538,"DIRECTION":"BI","MASTER_ID":31535,"compounds":"2-oxoglutarate + L-arginine + O2 <=> (S)-1-pyrroline-5-carboxylate + CO2 + guanidine + H(+) + H2O + succinate","pmd":27.995}
{"X":6328,"KEGG":"R09785","RHEA_ID":31538,"DIRECTION":"BI","MASTER_ID":31535,"compounds":"2-oxoglutarate + L-arginine + O2 <=> (S)-1-pyrroline-5-carboxylate + CO2 + guanidine + H(+) + H2O + succinate","pmd":56.085}
{"X":6329,"KEGG":"R09786","RHEA_ID":31358,"DIRECTION":"BI","MASTER_ID":31355,"compounds":"dimethyl sulfide + H(+) + NADH + O2 <=> formaldehyde + H2O + methanethiol + NAD(+)"}
{"X":6330,"KEGG":"R09787","RHEA_ID":59487,"DIRECTION":"BI","MASTER_ID":59484,"compounds":"2 [Fe(III)cytochrome c] + arsenite + H2O <=> 2 [Fe(II)cytochrome c] + arsenate + 3 H(+)"}
{"X":6331,"KEGG":"R09788","RHEA_ID":30954,"DIRECTION":"BI","MASTER_ID":30951,"compounds":"(2E,6E)-farnesyl diphosphate + H2O <=> alpha-eudesmol + diphosphate","pmd":159.933}
{"X":6332,"KEGG":"R09789","RHEA_ID":30950,"DIRECTION":"BI","MASTER_ID":30947,"compounds":"(2E,6E)-farnesyl diphosphate + H2O <=> 10-epi-gamma-eudesmol + diphosphate","pmd":159.933}
{"X":6333,"KEGG":"R09790","RHEA_ID":31614,"DIRECTION":"BI","MASTER_ID":31611,"metacyc":"RXN-12722","compounds":"1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene <=> H2O + rhodopin","pmd":18.01}
{"X":6334,"KEGG":"R09791","RHEA_ID":31542,"DIRECTION":"BI","MASTER_ID":31539,"compounds":"(S)-naringenin + S-adenosyl-L-methionine <=> (2S)-sakuranetin + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6335,"KEGG":"R09792","RHEA_ID":31746,"DIRECTION":"BI","MASTER_ID":31743,"compounds":"a 4'-hydroxyflavanone + S-adenosyl-L-methionine <=> a 4'-methoxyflavanone + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6336,"KEGG":"R09793","RHEA_ID":31554,"DIRECTION":"BI","MASTER_ID":31551,"compounds":"presqualene diphosphate <=> 15-cis-4,4'-diapophytoene + diphosphate","pmd":177.943}
{"X":6337,"KEGG":"R09794","RHEA_ID":31378,"DIRECTION":"BI","MASTER_ID":31375,"compounds":"H(+) + pyrrole-2-carboxylate <=> 1H-pyrrole + CO2"}
{"X":6338,"KEGG":"R09795","RHEA_ID":31382,"DIRECTION":"BI","MASTER_ID":31379,"compounds":"H2O + pyrrole-2-carboxylate <=> 1H-pyrrole + hydrogencarbonate"}
{"X":6339,"KEGG":"R09796","RHEA_ID":27757,"DIRECTION":"BI","MASTER_ID":27754,"compounds":"H2O + methylglyoxal <=> (R)-lactate + H(+)"}
{"X":6340,"KEGG":"R09798","RHEA_ID":31362,"DIRECTION":"BI","MASTER_ID":31359,"compounds":"FMNH2 + nitrilotriacetate + O2 <=> ammoniodiacetate + FMN + glyoxylate + H2O","pmd":2.016}
{"X":6341,"KEGG":"R09798","RHEA_ID":31362,"DIRECTION":"BI","MASTER_ID":31359,"compounds":"FMNH2 + nitrilotriacetate + O2 <=> ammoniodiacetate + FMN + glyoxylate + H2O","pmd":58.006}
{"X":6342,"KEGG":"R09799","RHEA_ID":49819,"DIRECTION":"BI","MASTER_ID":49816,"compounds":"3 [Fe(III)cytochrome c] + H2O + hydrazine <=> 3 [Fe(II)cytochrome c] + 2 H(+) + NH4(+) + nitric oxide"}
{"X":6343,"KEGG":"R09800","RHEA_ID":52307,"DIRECTION":"BI","MASTER_ID":52304,"compounds":"H2O + L-ectoine <=> (2S)-2-acetamido-4-aminobutanoate","pmd":18.011}
{"X":6344,"KEGG":"R09801","RHEA_ID":40954,"DIRECTION":"BI","MASTER_ID":40951,"compounds":"(2S)-2-acetamido-4-aminobutanoate + H2O <=> acetate + L-2,4-diaminobutanoate","pmd":42.011}
{"X":6345,"KEGG":"R09802","RHEA_ID":61167,"DIRECTION":"BI","MASTER_ID":61164,"compounds":"kaempferol + UDP-beta-L-rhamnose <=> H(+) + kaempferol 3-O-alpha-L-rhamnoside + UDP","pmd":117.955}
{"X":6346,"KEGG":"R09802","RHEA_ID":61167,"DIRECTION":"BI","MASTER_ID":61164,"compounds":"kaempferol + UDP-beta-L-rhamnose <=> H(+) + kaempferol 3-O-alpha-L-rhamnoside + UDP","pmd":117.954}
{"X":6347,"KEGG":"R09803","RHEA_ID":61163,"DIRECTION":"BI","MASTER_ID":61160,"compounds":"quercetin + UDP-beta-L-rhamnose <=> H(+) + quercitrin + UDP","pmd":101.96}
{"X":6348,"KEGG":"R09803","RHEA_ID":61163,"DIRECTION":"BI","MASTER_ID":61160,"compounds":"quercetin + UDP-beta-L-rhamnose <=> H(+) + quercitrin + UDP","pmd":101.959}
{"X":6349,"KEGG":"R09806","RHEA_ID":31678,"DIRECTION":"BI","MASTER_ID":31675,"compounds":"NADP(+) + raucaffrinoline <=> H(+) + NADPH + perakine","pmd":2.016}
{"X":6350,"KEGG":"R09806","RHEA_ID":31678,"DIRECTION":"BI","MASTER_ID":31675,"compounds":"NADP(+) + raucaffrinoline <=> H(+) + NADPH + perakine","pmd":393.92}
{"X":6351,"KEGG":"R09807","RHEA_ID":31682,"DIRECTION":"BI","MASTER_ID":31679,"compounds":"O2 + prosolanapyrone II <=> H2O2 + prosolanapyrone III","pmd":2.016}
{"X":6352,"KEGG":"R09810","RHEA_ID":31694,"DIRECTION":"BI","MASTER_ID":31691,"metacyc":"RXN-12760","compounds":"(9Z,12Z)-octadecadienoate + O2 <=> (9R,10E,12Z)-9-hydroperoxyoctadeca-10,12-dienoate","pmd":31.99}
{"X":6353,"KEGG":"R09810","RHEA_ID":31690,"DIRECTION":"BI","MASTER_ID":31687,"compounds":"(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate","pmd":31.99}
{"X":6354,"KEGG":"R09811","RHEA_ID":31698,"DIRECTION":"BI","MASTER_ID":31695,"compounds":"(9Z,12Z)-octadecadienoate + O2 <=> (8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate","pmd":31.99}
{"X":6355,"KEGG":"R09812","RHEA_ID":31706,"DIRECTION":"BI","MASTER_ID":31703,"compounds":"2 H(+) + O2 + pentalenene + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-ol","pmd":15.995}
{"X":6356,"KEGG":"R09813","RHEA_ID":31710,"DIRECTION":"BI","MASTER_ID":31707,"compounds":"2 H(+) + O2 + pentalen-13-ol + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al","pmd":2.016}
{"X":6357,"KEGG":"R09814","RHEA_ID":31702,"DIRECTION":"BI","MASTER_ID":31699,"compounds":"4 H(+) + 2 O2 + pentalenene + 4 reduced [2Fe-2S]-[ferredoxin] <=> 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al","pmd":13.979}
{"X":6358,"KEGG":"R09815","RHEA_ID":31718,"DIRECTION":"BI","MASTER_ID":31715,"compounds":"beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> 11alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":6359,"KEGG":"R09816","RHEA_ID":31722,"DIRECTION":"BI","MASTER_ID":31719,"compounds":"11alpha-hydroxy-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-oxo-beta-amyrin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]","pmd":2.016}
{"X":6360,"KEGG":"R09817","RHEA_ID":31714,"DIRECTION":"BI","MASTER_ID":31711,"compounds":"beta-amyrin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 11-oxo-beta-amyrin + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]","pmd":13.979}
{"X":6361,"KEGG":"R09818","RHEA_ID":31574,"DIRECTION":"BI","MASTER_ID":31571,"compounds":"1-hydroxy-2-naphthoate + 2 H(+) + NADPH + O2 <=> CO2 + H2O + NADP(+) + naphthalene-1,2-diol","pmd":585.039}
{"X":6362,"KEGG":"R09818","RHEA_ID":31574,"DIRECTION":"BI","MASTER_ID":31571,"compounds":"1-hydroxy-2-naphthoate + 2 H(+) + NADPH + O2 <=> CO2 + H2O + NADP(+) + naphthalene-1,2-diol","pmd":27.995}
{"X":6363,"KEGG":"R09819","RHEA_ID":31734,"DIRECTION":"BI","MASTER_ID":31731,"compounds":"3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 <=> 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H(+) + H2O","pmd":15.995}
{"X":6364,"KEGG":"R09819","RHEA_ID":31734,"DIRECTION":"BI","MASTER_ID":31731,"compounds":"3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 <=> 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H(+) + H2O","pmd":2.016}
{"X":6365,"KEGG":"R09821","RHEA_ID":31618,"DIRECTION":"BI","MASTER_ID":31615,"compounds":"dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose + 2 S-adenosyl-L-methionine <=> dTDP-D-ravidosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6366,"KEGG":"R09821","RHEA_ID":31618,"DIRECTION":"BI","MASTER_ID":31615,"compounds":"dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose + 2 S-adenosyl-L-methionine <=> dTDP-D-ravidosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine","pmd":28.031}
{"X":6367,"KEGG":"R09822","RHEA_ID":31646,"DIRECTION":"BI","MASTER_ID":31643,"compounds":"mycinamicin VI + S-adenosyl-L-methionine <=> H(+) + mycinamicin III + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6368,"KEGG":"R09823","RHEA_ID":31642,"DIRECTION":"BI","MASTER_ID":31639,"compounds":"mycinamicin III + S-adenosyl-L-methionine <=> H(+) + mycinamicin IV + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6369,"KEGG":"R09824","RHEA_ID":31622,"DIRECTION":"BI","MASTER_ID":31619,"metacyc":"RXN-12811","compounds":"2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose <=> dTDP-3-dehydro-6-deoxy-alpha-D-galactose + L-glutamate","pmd":1.032}
{"X":6370,"KEGG":"R09825","RHEA_ID":31770,"DIRECTION":"BI","MASTER_ID":31767,"metacyc":"RXN-9999","compounds":"2-oxoglutarate + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine <=> L-glutamate + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose","pmd":1.032}
{"X":6371,"KEGG":"R09826","RHEA_ID":31782,"DIRECTION":"BI","MASTER_ID":31779,"compounds":"an all-trans-retinyl ester + H2O <=> 13-cis-retinol + a fatty acid + H(+)"}
{"X":6372,"KEGG":"R09827","RHEA_ID":25531,"DIRECTION":"BI","MASTER_ID":25528,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate"}
{"X":6373,"KEGG":"R09828","RHEA_ID":31786,"DIRECTION":"BI","MASTER_ID":31783,"compounds":"H2O + tuberculosinyl diphosphate <=> diphosphate + tuberculosinol","pmd":159.933}
{"X":6374,"KEGG":"R09829","RHEA_ID":31794,"DIRECTION":"BI","MASTER_ID":31791,"compounds":"H2O + tuberculosinyl diphosphate <=> (13S)-edaxadiene + diphosphate","pmd":159.933}
{"X":6375,"KEGG":"R09831","RHEA_ID":31638,"DIRECTION":"BI","MASTER_ID":31635,"compounds":"beta-D-Delta(4)-GlcpA-(1->4)-beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-D-Glcp + H2O <=> 5-dehydro-4-deoxy-D-glucuronate + beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-D-Glcp","pmd":158.022}
{"X":6376,"KEGG":"R09834","RHEA_ID":31806,"DIRECTION":"BI","MASTER_ID":31803,"compounds":"H2O + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose <=> 2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H(+) + UDP","pmd":228.111}
{"X":6377,"KEGG":"R09835","RHEA_ID":31798,"DIRECTION":"BI","MASTER_ID":31795,"metacyc":"RXN-12775","compounds":"(+)-beta-caryophyllene + H2O <=> (+)-caryolan-1-ol","pmd":18.011}
{"X":6378,"KEGG":"R09839","RHEA_ID":34442,"DIRECTION":"BI","MASTER_ID":34439,"compounds":"2,3-didehydroadipyl-CoA + acetyl-CoA <=> 3-oxo-5,6-didehydrosuberyl-CoA + CoA","pmd":42.011}
{"X":6379,"KEGG":"R09841","RHEA_ID":31634,"DIRECTION":"BI","MASTER_ID":31631,"compounds":"2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H2O + phosphoenolpyruvate <=> phosphate + pseudaminate","pmd":88.016}
{"X":6380,"KEGG":"R09841","RHEA_ID":31634,"DIRECTION":"BI","MASTER_ID":31631,"compounds":"2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H2O + phosphoenolpyruvate <=> phosphate + pseudaminate","pmd":166.155}
{"X":6381,"KEGG":"R09842","RHEA_ID":34158,"DIRECTION":"BI","MASTER_ID":34155,"compounds":"acetyl-CoA + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine <=> CoA + H(+) + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose","pmd":42.011}
{"X":6382,"KEGG":"R09843","RHEA_ID":32086,"DIRECTION":"BI","MASTER_ID":32083,"compounds":"CTP + pseudaminate <=> CMP-pseudaminate + diphosphate","pmd":156.194}
{"X":6383,"KEGG":"R09843","RHEA_ID":32086,"DIRECTION":"BI","MASTER_ID":32083,"compounds":"CTP + pseudaminate <=> CMP-pseudaminate + diphosphate","pmd":305.041}
{"X":6384,"KEGG":"R09844","RHEA_ID":13348,"DIRECTION":"BI","MASTER_ID":13345,"metacyc":"2.5.1.58-RXN","compounds":"(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] <=> diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein]"}
{"X":6385,"KEGG":"R09846","RHEA_ID":48523,"DIRECTION":"BI","MASTER_ID":48520,"compounds":"[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + H2O <=> [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + H(+) + methanol"}
{"X":6386,"KEGG":"R09849","RHEA_ID":51683,"DIRECTION":"BI","MASTER_ID":51680,"compounds":"(2E,6E)-farnesol + CTP <=> (2E,6E)-farnesyl phosphate + CDP + H(+)","pmd":79.966}
{"X":6387,"KEGG":"R09850","RHEA_ID":51687,"DIRECTION":"BI","MASTER_ID":51684,"compounds":"(2E,6E)-farnesyl phosphate + CTP <=> (2E,6E)-farnesyl diphosphate + CDP","pmd":79.966}
{"X":6388,"KEGG":"R09859","RHEA_ID":31946,"DIRECTION":"BI","MASTER_ID":31943,"compounds":"cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (25S)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]","pmd":15.995}
{"X":6389,"KEGG":"R09860","RHEA_ID":32202,"DIRECTION":"BI","MASTER_ID":32199,"compounds":"androsta-1,4-diene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]","pmd":15.995}
{"X":6390,"KEGG":"R09861","RHEA_ID":31950,"DIRECTION":"BI","MASTER_ID":31947,"compounds":"ent-isokaurene + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-isokauren-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":6391,"KEGG":"R09862","RHEA_ID":31958,"DIRECTION":"BI","MASTER_ID":31955,"compounds":"9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> 9beta-pimara-7,15-dien-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":6392,"KEGG":"R09863","RHEA_ID":31962,"DIRECTION":"BI","MASTER_ID":31959,"compounds":"9beta-pimara-7,15-dien-19-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> 9beta-pimara-7,15-dien-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]","pmd":2.016}
{"X":6393,"KEGG":"R09864","RHEA_ID":31966,"DIRECTION":"BI","MASTER_ID":31963,"compounds":"9beta-pimara-7,15-dien-19-al + O2 + reduced [NADPH--hemoprotein reductase] <=> 9beta-pimara-7,15-dien-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":6394,"KEGG":"R09865","RHEA_ID":31954,"DIRECTION":"BI","MASTER_ID":31951,"compounds":"9beta-pimara-7,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 9beta-pimara-7,15-dien-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]","pmd":29.974}
{"X":6395,"KEGG":"R09866","RHEA_ID":31970,"DIRECTION":"BI","MASTER_ID":31967,"compounds":"ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-11beta-hydroxycassa-12,15-diene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":6396,"KEGG":"R09867","RHEA_ID":31974,"DIRECTION":"BI","MASTER_ID":31971,"compounds":"10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + NADPH + O2 <=> 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + H2O + NADP(+)","pmd":382.845}
{"X":6397,"KEGG":"R09867","RHEA_ID":31974,"DIRECTION":"BI","MASTER_ID":31971,"compounds":"10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + NADPH + O2 <=> 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + H2O + NADP(+)","pmd":15.995}
{"X":6398,"KEGG":"R09868","RHEA_ID":31978,"DIRECTION":"BI","MASTER_ID":31975,"compounds":"H(+) + NADPH + O2 + taxusin <=> 7beta-hydroxytaxusin + H2O + NADP(+)","pmd":15.995}
{"X":6399,"KEGG":"R09868","RHEA_ID":31978,"DIRECTION":"BI","MASTER_ID":31975,"compounds":"H(+) + NADPH + O2 + taxusin <=> 7beta-hydroxytaxusin + H2O + NADP(+)","pmd":224.824}
{"X":6400,"KEGG":"R09870","RHEA_ID":32114,"DIRECTION":"BI","MASTER_ID":32111,"compounds":"S-adenosyl-L-methionine + trans-resveratrol <=> 3-methoxy-4',5-dihydroxy-trans-stilbene + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6401,"KEGG":"R09871","RHEA_ID":32110,"DIRECTION":"BI","MASTER_ID":32107,"compounds":"3-methoxy-4',5-dihydroxy-trans-stilbene + S-adenosyl-L-methionine <=> H(+) + pterostilbene + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6402,"KEGG":"R09872","RHEA_ID":32106,"DIRECTION":"BI","MASTER_ID":32103,"compounds":"2 S-adenosyl-L-methionine + trans-resveratrol <=> 2 H(+) + pterostilbene + 2 S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6403,"KEGG":"R09872","RHEA_ID":32106,"DIRECTION":"BI","MASTER_ID":32103,"compounds":"2 S-adenosyl-L-methionine + trans-resveratrol <=> 2 H(+) + pterostilbene + 2 S-adenosyl-L-homocysteine","pmd":28.031}
{"X":6404,"KEGG":"R09873","RHEA_ID":32098,"DIRECTION":"BI","MASTER_ID":32095,"compounds":"acetyl-CoA + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose <=> CoA + dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactopyranose + H(+)","pmd":42.011}
{"X":6405,"KEGG":"R09874","RHEA_ID":32078,"DIRECTION":"BI","MASTER_ID":32075,"compounds":"geranylgeranyl diphosphate + H2O <=> (13E)-labda-7,13-dien-15-ol + diphosphate","pmd":159.933}
{"X":6406,"KEGG":"R09875","RHEA_ID":31566,"DIRECTION":"BI","MASTER_ID":31563,"compounds":"H2O + leukotriene C4 <=> L-glutamate + leukotriene D4","pmd":129.043}
{"X":6407,"KEGG":"R09876","RHEA_ID":32070,"DIRECTION":"BI","MASTER_ID":32067,"metacyc":"RXN-11455","compounds":"8-oxoguanine + H(+) + H2O <=> NH4(+) + urate","pmd":0.984}
{"X":6408,"KEGG":"R09877","RHEA_ID":32066,"DIRECTION":"BI","MASTER_ID":32063,"compounds":"8-oxo-dGDP + H2O <=> 8-oxo-dGMP + H(+) + phosphate","pmd":79.966}
{"X":6409,"KEGG":"R09879","RHEA_ID":32046,"DIRECTION":"BI","MASTER_ID":32043,"metacyc":"RXN-12819","compounds":"H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate <=> 2 ATP + 2 H(+)","pmd":488.985}
{"X":6410,"KEGG":"R09880","RHEA_ID":30530,"DIRECTION":"BI","MASTER_ID":30527,"metacyc":"RXN-10966","compounds":"H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate <=> ADP + ATP + 2 H(+)","pmd":409.019}
{"X":6411,"KEGG":"R09881","RHEA_ID":32050,"DIRECTION":"BI","MASTER_ID":32047,"metacyc":"RXN-10967","compounds":"H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate <=> adenosine 5'-pentaphosphate + AMP + 2 H(+)","pmd":329.053}
{"X":6412,"KEGG":"R09882","RHEA_ID":32054,"DIRECTION":"BI","MASTER_ID":32051,"metacyc":"RXN-10774","compounds":"H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate <=> adenosine 5'-tetraphosphate + AMP + 2 H(+)","pmd":329.053}
{"X":6413,"KEGG":"R09883","RHEA_ID":32038,"DIRECTION":"BI","MASTER_ID":32035,"compounds":"(1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H2O <=> (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + H(+)","pmd":110.037}
{"X":6414,"KEGG":"R09884","RHEA_ID":51059,"DIRECTION":"BI","MASTER_ID":51056,"compounds":"A + androst-4-ene-3,17-dione <=> AH2 + androsta-1,4-diene-3,17-dione","pmd":2.016}
{"X":6415,"KEGG":"R09886","RHEA_ID":30386,"DIRECTION":"BI","MASTER_ID":30383,"compounds":"(2E,6E)-farnesyl diphosphate <=> (-)-7-epi-alpha-selinene + diphosphate","pmd":177.943}
{"X":6416,"KEGG":"R09887","RHEA_ID":31810,"DIRECTION":"BI","MASTER_ID":31807,"compounds":"(2E,6E)-farnesyl diphosphate <=> alpha-guaiene + diphosphate","pmd":177.943}
{"X":6417,"KEGG":"R09888","RHEA_ID":31814,"DIRECTION":"BI","MASTER_ID":31811,"compounds":"(2E,6E)-farnesyl diphosphate <=> diphosphate + viridiflorene","pmd":177.943}
{"X":6418,"KEGG":"R09889","RHEA_ID":31818,"DIRECTION":"BI","MASTER_ID":31815,"compounds":"(2E,6E)-farnesyl diphosphate <=> (+)-beta-caryophyllene + diphosphate","pmd":177.943}
{"X":6419,"KEGG":"R09890","RHEA_ID":31822,"DIRECTION":"BI","MASTER_ID":31819,"compounds":"(2E,6E)-farnesyl diphosphate <=> 5-epi-alpha-selinene + diphosphate","pmd":177.943}
{"X":6420,"KEGG":"R09891","RHEA_ID":31826,"DIRECTION":"BI","MASTER_ID":31823,"compounds":"(2E,6E)-farnesyl diphosphate + H2O <=> cubebol + diphosphate","pmd":159.933}
{"X":6421,"KEGG":"R09892","RHEA_ID":31830,"DIRECTION":"BI","MASTER_ID":31827,"compounds":"(2E,6E)-farnesyl diphosphate <=> (+)-gamma-cadinene + diphosphate","pmd":177.943}
{"X":6422,"KEGG":"R09893","RHEA_ID":31834,"DIRECTION":"BI","MASTER_ID":31831,"compounds":"(2E,6E)-farnesyl diphosphate <=> delta-guaiene + diphosphate","pmd":177.943}
{"X":6423,"KEGG":"R09894","RHEA_ID":32034,"DIRECTION":"BI","MASTER_ID":32031,"compounds":"(2E,6E)-farnesyl diphosphate <=> diphosphate + gamma-curcumene","pmd":177.943}
{"X":6424,"KEGG":"R09895","RHEA_ID":32030,"DIRECTION":"BI","MASTER_ID":32027,"compounds":"(2E,6E)-farnesyl diphosphate <=> (-)-alpha-cuprenene + diphosphate","pmd":177.943}
{"X":6425,"KEGG":"R09896","RHEA_ID":32026,"DIRECTION":"BI","MASTER_ID":32023,"compounds":"(2E,6E)-farnesyl diphosphate + H2O <=> avermitilol + diphosphate","pmd":159.933}
{"X":6426,"KEGG":"R09897","RHEA_ID":32018,"DIRECTION":"BI","MASTER_ID":32015,"compounds":"(2E,6E)-farnesyl diphosphate <=> (-)-delta-cadinene + diphosphate","pmd":177.943}
{"X":6427,"KEGG":"R09898","RHEA_ID":32014,"DIRECTION":"BI","MASTER_ID":32011,"compounds":"(2E,6E)-farnesyl diphosphate + H2O <=> (+)-T-muurolol + diphosphate","pmd":159.933}
{"X":6428,"KEGG":"R09900","RHEA_ID":32002,"DIRECTION":"BI","MASTER_ID":31999,"compounds":"(2E,6E)-farnesyl diphosphate <=> bicyclogermacrene + diphosphate","pmd":177.943}
{"X":6429,"KEGG":"R09901","RHEA_ID":31998,"DIRECTION":"BI","MASTER_ID":31995,"compounds":"(2E,6E)-farnesyl diphosphate <=> 7-epi-sesquithujene + diphosphate","pmd":177.943}
{"X":6430,"KEGG":"R09902","RHEA_ID":31994,"DIRECTION":"BI","MASTER_ID":31991,"compounds":"(2E,6E)-farnesyl diphosphate <=> diphosphate + sesquithujene","pmd":177.943}
{"X":6431,"KEGG":"R09903","RHEA_ID":25762,"DIRECTION":"BI","MASTER_ID":25759,"compounds":"ent-copalyl diphosphate <=> diphosphate + ent-isokaurene","pmd":177.943}
{"X":6432,"KEGG":"R09904","RHEA_ID":31838,"DIRECTION":"BI","MASTER_ID":31835,"compounds":"dTDP-4-dehydro-6-deoxy-alpha-D-glucose <=> dTDP-3-dehydro-6-deoxy-alpha-D-galactose","pmd":0}
{"X":6433,"KEGG":"R09905","RHEA_ID":31582,"DIRECTION":"BI","MASTER_ID":31579,"metacyc":"RXN-12757","compounds":"(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate <=> (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate","pmd":0}
{"X":6434,"KEGG":"R09906","RHEA_ID":31850,"DIRECTION":"BI","MASTER_ID":31847,"metacyc":"RXN-12841","compounds":"(S)-2,3-epoxysqualene <=> shionone","pmd":0}
{"X":6435,"KEGG":"R09907","RHEA_ID":31854,"DIRECTION":"BI","MASTER_ID":31851,"metacyc":"RXN-12842","compounds":"(S)-2,3-epoxysqualene <=> parkeol","pmd":0}
{"X":6436,"KEGG":"R09908","RHEA_ID":31858,"DIRECTION":"BI","MASTER_ID":31855,"metacyc":"RXN-12843","compounds":"(S)-2,3-epoxysqualene <=> achilleol B","pmd":0}
{"X":6437,"KEGG":"R09909","RHEA_ID":31862,"DIRECTION":"BI","MASTER_ID":31859,"compounds":"(S)-2,3-epoxysqualene <=> glutinol","pmd":0}
{"X":6438,"KEGG":"R09910","RHEA_ID":31866,"DIRECTION":"BI","MASTER_ID":31863,"metacyc":"RXN-12101","compounds":"(S)-2,3-epoxysqualene <=> friedelin","pmd":0}
{"X":6439,"KEGG":"R09911","RHEA_ID":31870,"DIRECTION":"BI","MASTER_ID":31867,"metacyc":"RXN-12844","compounds":"(S)-2,3-epoxysqualene <=> baccharis oxide","pmd":0}
{"X":6440,"KEGG":"R09912","RHEA_ID":31874,"DIRECTION":"BI","MASTER_ID":31871,"metacyc":"RXN-12845","compounds":"(S)-2,3-epoxysqualene <=> alpha-seco-amyrin","pmd":0}
{"X":6441,"KEGG":"R09913","RHEA_ID":31878,"DIRECTION":"BI","MASTER_ID":31875,"metacyc":"RXN-9664","compounds":"(S)-2,3-epoxysqualene <=> marneral","pmd":0}
{"X":6442,"KEGG":"R09914","RHEA_ID":31882,"DIRECTION":"BI","MASTER_ID":31879,"metacyc":"RXN-12846","compounds":"(S)-2,3-epoxysqualene <=> beta-seco-amyrin","pmd":0}
{"X":6443,"KEGG":"R09915","RHEA_ID":31886,"DIRECTION":"BI","MASTER_ID":31883,"metacyc":"RXN-12847","compounds":"(S)-2,3-epoxysqualene <=> delta-amyrin","pmd":0}
{"X":6444,"KEGG":"R09917","RHEA_ID":31990,"DIRECTION":"BI","MASTER_ID":31987,"metacyc":"RXN-9685","compounds":"(S)-2,3-epoxysqualene <=> baruol","pmd":0}
{"X":6445,"KEGG":"R09918","RHEA_ID":31686,"DIRECTION":"BI","MASTER_ID":31683,"metacyc":"RXN-12675","compounds":"prosolanapyrone III <=> (-)-solanapyrone A","pmd":0}
{"X":6446,"KEGG":"R09924","RHEA_ID":32642,"DIRECTION":"BI","MASTER_ID":32639,"compounds":"(6E)-8-hydroxylinalool + O2 + reduced [NADPH--hemoprotein reductase] <=> (6E)-8-oxolinalool + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]","pmd":2.016}
{"X":6447,"KEGG":"R09925","RHEA_ID":32638,"DIRECTION":"BI","MASTER_ID":32635,"compounds":"linalool + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (6E)-8-oxolinalool + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]","pmd":13.979}
{"X":6448,"KEGG":"R09926","RHEA_ID":32610,"DIRECTION":"BI","MASTER_ID":32607,"metacyc":"RXN-9367","compounds":"(6E)-8-hydroxygeraniol + NADP(+) <=> (6E)-8-hydroxygeranial + H(+) + NADPH","pmd":2.016}
{"X":6449,"KEGG":"R09926","RHEA_ID":32610,"DIRECTION":"BI","MASTER_ID":32607,"metacyc":"RXN-9367","compounds":"(6E)-8-hydroxygeraniol + NADP(+) <=> (6E)-8-hydroxygeranial + H(+) + NADPH","pmd":575.968}
{"X":6450,"KEGG":"R09927","RHEA_ID":32614,"DIRECTION":"BI","MASTER_ID":32611,"compounds":"(6E)-8-hydroxygeranial + NADP(+) <=> (6E)-8-oxogeranial + H(+) + NADPH","pmd":2.016}
{"X":6451,"KEGG":"R09927","RHEA_ID":32614,"DIRECTION":"BI","MASTER_ID":32611,"compounds":"(6E)-8-hydroxygeranial + NADP(+) <=> (6E)-8-oxogeranial + H(+) + NADPH","pmd":577.984}
{"X":6452,"KEGG":"R09928","RHEA_ID":32606,"DIRECTION":"BI","MASTER_ID":32603,"metacyc":"RXN-9368","compounds":"(6E)-8-hydroxygeraniol + NADP(+) <=> (6E)-8-oxogeraniol + H(+) + NADPH","pmd":2.016}
{"X":6453,"KEGG":"R09928","RHEA_ID":32606,"DIRECTION":"BI","MASTER_ID":32603,"metacyc":"RXN-9368","compounds":"(6E)-8-hydroxygeraniol + NADP(+) <=> (6E)-8-oxogeraniol + H(+) + NADPH","pmd":575.968}
{"X":6454,"KEGG":"R09929","RHEA_ID":32618,"DIRECTION":"BI","MASTER_ID":32615,"compounds":"(6E)-8-oxogeraniol + NADP(+) <=> (6E)-8-oxogeranial + H(+) + NADPH","pmd":577.984}
{"X":6455,"KEGG":"R09929","RHEA_ID":32618,"DIRECTION":"BI","MASTER_ID":32615,"compounds":"(6E)-8-oxogeraniol + NADP(+) <=> (6E)-8-oxogeranial + H(+) + NADPH","pmd":2.016}
{"X":6456,"KEGG":"R09930","RHEA_ID":32658,"DIRECTION":"BI","MASTER_ID":32655,"compounds":"a carboxylate + eugenol + NADP(+) <=> a coniferyl ester + NADPH","pmd":581.007}
{"X":6457,"KEGG":"R09931","RHEA_ID":24697,"DIRECTION":"BI","MASTER_ID":24694,"compounds":"acetate + NADP(+) + trans-isoeugenol <=> coniferyl acetate + NADPH","pmd":521.994}
{"X":6458,"KEGG":"R09931","RHEA_ID":24697,"DIRECTION":"BI","MASTER_ID":24694,"compounds":"acetate + NADP(+) + trans-isoeugenol <=> coniferyl acetate + NADPH","pmd":58.006}
{"X":6459,"KEGG":"R09932","RHEA_ID":25971,"DIRECTION":"BI","MASTER_ID":25968,"metacyc":"RXN-12898","compounds":"(S)-benzoin + NADP(+) <=> benzil + H(+) + NADPH","pmd":2.016}
{"X":6460,"KEGG":"R09932","RHEA_ID":25971,"DIRECTION":"BI","MASTER_ID":25968,"metacyc":"RXN-12898","compounds":"(S)-benzoin + NADP(+) <=> benzil + H(+) + NADPH","pmd":534.015}
{"X":6461,"KEGG":"R09933","RHEA_ID":25967,"DIRECTION":"BI","MASTER_ID":25964,"compounds":"(R)-benzoin + NADP(+) <=> benzil + H(+) + NADPH","pmd":2.016}
{"X":6462,"KEGG":"R09933","RHEA_ID":25967,"DIRECTION":"BI","MASTER_ID":25964,"compounds":"(R)-benzoin + NADP(+) <=> benzil + H(+) + NADPH","pmd":534.015}
{"X":6463,"KEGG":"R09934","RHEA_ID":32494,"DIRECTION":"BI","MASTER_ID":32491,"compounds":"(1E,4E,8E)-alpha-humulene + O2 + reduced [NADPH--hemoprotein reductase] <=> 10-hydroxy-alpha-humulene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":6464,"KEGG":"R09936","RHEA_ID":31590,"DIRECTION":"BI","MASTER_ID":31587,"compounds":"FMNH2 + NADH + O2 + uracil <=> (Z)-3-ureidoacrylate + FMN + H(+) + H2O + NAD(+)","pmd":2.016}
{"X":6465,"KEGG":"R09936","RHEA_ID":31590,"DIRECTION":"BI","MASTER_ID":31587,"compounds":"FMNH2 + NADH + O2 + uracil <=> (Z)-3-ureidoacrylate + FMN + H(+) + H2O + NAD(+)","pmd":34.006}
{"X":6466,"KEGG":"R09937","RHEA_ID":31602,"DIRECTION":"BI","MASTER_ID":31599,"compounds":"FMNH2 + NADH + O2 + thymine <=> (Z)-2-methylureidoacrylate + FMN + H(+) + H2O + NAD(+)","pmd":2.016}
{"X":6467,"KEGG":"R09937","RHEA_ID":31602,"DIRECTION":"BI","MASTER_ID":31599,"compounds":"FMNH2 + NADH + O2 + thymine <=> (Z)-2-methylureidoacrylate + FMN + H(+) + H2O + NAD(+)","pmd":34.005}
{"X":6468,"KEGG":"R09938","RHEA_ID":32646,"DIRECTION":"BI","MASTER_ID":32643,"metacyc":"RXN-12887","compounds":"2 [Fe(III)cytochrome c] + H2O + lupanine <=> 17-hydroxylupanine + 2 [Fe(II)cytochrome c] + 2 H(+)","pmd":15.995}
{"X":6469,"KEGG":"R09939","RHEA_ID":32666,"DIRECTION":"BI","MASTER_ID":32663,"compounds":"5-guanidino-2-oxopentanoate + S-adenosyl-L-methionine <=> 5-guanidino-3-methyl-2-oxopentanoate + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6470,"KEGG":"R09940","RHEA_ID":32522,"DIRECTION":"BI","MASTER_ID":32519,"compounds":"(2E)-geranyl diphosphate + S-adenosyl-L-methionine <=> (E)-2-methylgeranyl diphosphate + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6471,"KEGG":"R09941","RHEA_ID":32526,"DIRECTION":"BI","MASTER_ID":32523,"metacyc":"RXN-12958","compounds":"nigerose + phosphate <=> beta-D-glucose 1-phosphate + D-glucose","pmd":82.087}
{"X":6472,"KEGG":"R09942","RHEA_ID":32530,"DIRECTION":"BI","MASTER_ID":32527,"metacyc":"RXN-12627","compounds":"N,N'-diacetylchitobiose + phosphate <=> N-acetyl-alpha-D-glucosamine 1-phosphate + N-acetyl-D-glucosamine","pmd":123.113}
{"X":6473,"KEGG":"R09943","RHEA_ID":32534,"DIRECTION":"BI","MASTER_ID":32531,"metacyc":"RXN-12977","compounds":"4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate <=> alpha-D-mannose 1-phosphate + D-glucose","pmd":82.087}
{"X":6474,"KEGG":"R09944","RHEA_ID":25951,"DIRECTION":"BI","MASTER_ID":25948,"compounds":"a 1,2-diacyl-sn-glycerol + CTP <=> a 1,2-diacyl-sn-glycero-3-phosphate + CDP + H(+)","pmd":79.966}
{"X":6475,"KEGG":"R09945","RHEA_ID":31918,"DIRECTION":"BI","MASTER_ID":31915,"metacyc":"RXN-12960","compounds":"ATP + D-maltose <=> ADP + alpha-maltose 1-phosphate + H(+)","pmd":79.966}
{"X":6476,"KEGG":"R09946","RHEA_ID":32674,"DIRECTION":"BI","MASTER_ID":32671,"metacyc":"RXN-12979","compounds":"ATP + UDP-N-acetyl-alpha-D-glucosamine <=> ADP + H(+) + UDP-N-acetyl-alpha-D-glucosamine 3'-phosphate","pmd":79.966}
{"X":6477,"KEGG":"R09947","RHEA_ID":31594,"DIRECTION":"BI","MASTER_ID":31591,"compounds":"(Z)-3-ureidoacrylate peracid + H2O <=> (Z)-3-aminoperacrylic acid + carbamate + H(+)","pmd":43.006}
{"X":6478,"KEGG":"R09948","RHEA_ID":42619,"DIRECTION":"BI","MASTER_ID":42616,"compounds":"(Z)-3-ureidoacrylate peracid + H(+) + H2O <=> (Z)-3-aminoperacrylic acid + CO2 + NH4(+)","pmd":43.006}
{"X":6479,"KEGG":"R09949","RHEA_ID":31598,"DIRECTION":"BI","MASTER_ID":31595,"compounds":"(Z)-2-methylureidoacrylate + H2O <=> (Z)-2-methylaminoacrylate + carbamate + H(+)","pmd":43.006}
{"X":6480,"KEGG":"R09950","RHEA_ID":42623,"DIRECTION":"BI","MASTER_ID":42620,"compounds":"(Z)-2-methylureidoacrylate + H(+) + H2O <=> (Z)-2-methylaminoacrylate + CO2 + NH4(+)","pmd":43.006}
{"X":6481,"KEGG":"R09951","RHEA_ID":25835,"DIRECTION":"BI","MASTER_ID":25832,"metacyc":"RXN-14148","compounds":"1D-chiro-inositol + NAD(+) <=> H(+) + NADH + scyllo-inosine","pmd":486.069}
{"X":6482,"KEGG":"R09951","RHEA_ID":25835,"DIRECTION":"BI","MASTER_ID":25832,"metacyc":"RXN-14148","compounds":"1D-chiro-inositol + NAD(+) <=> H(+) + NADH + scyllo-inosine","pmd":2.016}
{"X":6483,"KEGG":"R09952","RHEA_ID":25779,"DIRECTION":"BI","MASTER_ID":25776,"metacyc":"RXN-14178","compounds":"scyllo-inosose <=> scyllo-inosine","pmd":0}
{"X":6484,"KEGG":"R09953","RHEA_ID":17616,"DIRECTION":"BI","MASTER_ID":17613,"metacyc":"RXN-13779","compounds":"NAD(+) + scyllo-inositol <=> H(+) + NADH + scyllo-inosose","pmd":2.016}
{"X":6485,"KEGG":"R09953","RHEA_ID":17616,"DIRECTION":"BI","MASTER_ID":17613,"metacyc":"RXN-13779","compounds":"NAD(+) + scyllo-inositol <=> H(+) + NADH + scyllo-inosose","pmd":486.069}
{"X":6486,"KEGG":"R09954","RHEA_ID":39066,"DIRECTION":"BI","MASTER_ID":39063,"metacyc":"RXN-14347","compounds":"NADP(+) + scyllo-inositol <=> H(+) + NADPH + scyllo-inosose","pmd":2.016}
{"X":6487,"KEGG":"R09954","RHEA_ID":39066,"DIRECTION":"BI","MASTER_ID":39063,"metacyc":"RXN-14347","compounds":"NADP(+) + scyllo-inositol <=> H(+) + NADPH + scyllo-inosose","pmd":566.036}
{"X":6488,"KEGG":"R09958","RHEA_ID":32134,"DIRECTION":"BI","MASTER_ID":32131,"metacyc":"RXN-13029","compounds":"(2S)-ethylmalonyl-CoA + H(+) <=> butanoyl-CoA + CO2","pmd":43.99}
{"X":6489,"KEGG":"R09959","RHEA_ID":27969,"DIRECTION":"BI","MASTER_ID":27966,"compounds":"7,8-dihydroneopterin 3'-triphosphate + H2O <=> 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate","pmd":283.925}
{"X":6490,"KEGG":"R09960","RHEA_ID":32538,"DIRECTION":"BI","MASTER_ID":32535,"compounds":"(2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H2O <=> 4-hydroxy-2-oxohexanoate","pmd":18.011}
{"X":6491,"KEGG":"R09961","RHEA_ID":32690,"DIRECTION":"BI","MASTER_ID":32687,"compounds":"(2E)-geranyl diphosphate <=> diphosphate + tricyclene","pmd":177.943}
{"X":6492,"KEGG":"R09962","RHEA_ID":32694,"DIRECTION":"BI","MASTER_ID":32691,"compounds":"(2E)-geranyl diphosphate <=> (E)-beta-ocimene + diphosphate","pmd":177.943}
{"X":6493,"KEGG":"R09963","RHEA_ID":32542,"DIRECTION":"BI","MASTER_ID":32539,"compounds":"(2E)-geranyl diphosphate <=> (+)-car-3-ene + diphosphate","pmd":177.943}
{"X":6494,"KEGG":"R09964","RHEA_ID":32546,"DIRECTION":"BI","MASTER_ID":32543,"compounds":"(2E)-geranyl diphosphate + H2O <=> 1,8-cineole + diphosphate","pmd":159.933}
{"X":6495,"KEGG":"R09965","RHEA_ID":25511,"DIRECTION":"BI","MASTER_ID":25508,"compounds":"(2E)-geranyl diphosphate <=> (1S,5S)-sabinene + diphosphate","pmd":177.943}
{"X":6496,"KEGG":"R09966","RHEA_ID":32550,"DIRECTION":"BI","MASTER_ID":32547,"compounds":"(2E)-geranyl diphosphate <=> (1R,5R)-sabinene + diphosphate","pmd":177.943}
{"X":6497,"KEGG":"R09967","RHEA_ID":32706,"DIRECTION":"BI","MASTER_ID":32703,"compounds":"all-trans-geranylgeranyl diphosphate + H2O <=> 8-hydroxycopalyl diphosphate","pmd":18.011}
{"X":6498,"KEGG":"R09968","RHEA_ID":32558,"DIRECTION":"BI","MASTER_ID":32555,"compounds":"(2E)-geranyl diphosphate + H2O <=> (R)-alpha-terpineol + diphosphate","pmd":159.933}
{"X":6499,"KEGG":"R09969","RHEA_ID":32562,"DIRECTION":"BI","MASTER_ID":32559,"compounds":"(2E)-geranyl diphosphate <=> diphosphate + gamma-terpinene","pmd":177.943}
{"X":6500,"KEGG":"R09970","RHEA_ID":32566,"DIRECTION":"BI","MASTER_ID":32563,"compounds":"(2E)-geranyl diphosphate <=> alpha-terpinene + diphosphate","pmd":177.943}
{"X":6501,"KEGG":"R09971","RHEA_ID":32570,"DIRECTION":"BI","MASTER_ID":32567,"compounds":"(2E)-geranyl diphosphate <=> (1R,4S)-camphene + diphosphate","pmd":177.943}
{"X":6502,"KEGG":"R09972","RHEA_ID":25487,"DIRECTION":"BI","MASTER_ID":25484,"compounds":"(2E)-geranyl diphosphate <=> (1S,4R)-camphene + diphosphate","pmd":177.943}
{"X":6503,"KEGG":"R09973","RHEA_ID":32574,"DIRECTION":"BI","MASTER_ID":32571,"compounds":"(E)-2-methylgeranyl diphosphate + H2O <=> 2-methylisoborneol + diphosphate","pmd":159.933}
{"X":6504,"KEGG":"R09974","RHEA_ID":32578,"DIRECTION":"BI","MASTER_ID":32575,"compounds":"(2E)-geranyl diphosphate <=> (1R,5R)-alpha-pinene + diphosphate","pmd":177.943}
{"X":6505,"KEGG":"R09975","RHEA_ID":32582,"DIRECTION":"BI","MASTER_ID":32579,"compounds":"(2E)-geranyl diphosphate <=> (1R,5R)-beta-pinene + diphosphate","pmd":177.943}
{"X":6506,"KEGG":"R09976","RHEA_ID":32702,"DIRECTION":"BI","MASTER_ID":32699,"compounds":"(2E,6E)-farnesyl diphosphate <=> beta-sesquiphellandrene + diphosphate","pmd":177.943}
{"X":6507,"KEGG":"R09977","RHEA_ID":31462,"DIRECTION":"BI","MASTER_ID":31459,"compounds":"2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate <=> 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate","pmd":0}
{"X":6508,"KEGG":"R09979","RHEA_ID":59731,"DIRECTION":"BI","MASTER_ID":59728,"compounds":"(2R)-ethylmalonyl-CoA <=> (2S)-ethylmalonyl-CoA","pmd":0}
{"X":6509,"KEGG":"R09984","RHEA_ID":32334,"DIRECTION":"BI","MASTER_ID":32331,"compounds":"(1S,2S,4R)-endo-fenchol + NAD(+) <=> (1S,4R)-fenchone + H(+) + NADH","pmd":2.016}
{"X":6510,"KEGG":"R09984","RHEA_ID":32334,"DIRECTION":"BI","MASTER_ID":32331,"compounds":"(1S,2S,4R)-endo-fenchol + NAD(+) <=> (1S,4R)-fenchone + H(+) + NADH","pmd":511.997}
{"X":6511,"KEGG":"R09985","RHEA_ID":32338,"DIRECTION":"BI","MASTER_ID":32335,"compounds":"(1S,2S,4R)-endo-fenchol + NADP(+) <=> (1S,4R)-fenchone + H(+) + NADPH","pmd":591.963}
{"X":6512,"KEGG":"R09985","RHEA_ID":32338,"DIRECTION":"BI","MASTER_ID":32335,"compounds":"(1S,2S,4R)-endo-fenchol + NADP(+) <=> (1S,4R)-fenchone + H(+) + NADPH","pmd":2.016}
{"X":6513,"KEGG":"R09986","RHEA_ID":32346,"DIRECTION":"BI","MASTER_ID":32343,"metacyc":"RXN-12956","compounds":"(+)-thujan-3-ol + NAD(+) <=> (+)-thujan-3-one + H(+) + NADH","pmd":2.016}
{"X":6514,"KEGG":"R09986","RHEA_ID":32346,"DIRECTION":"BI","MASTER_ID":32343,"metacyc":"RXN-12956","compounds":"(+)-thujan-3-ol + NAD(+) <=> (+)-thujan-3-one + H(+) + NADH","pmd":511.997}
{"X":6515,"KEGG":"R09987","RHEA_ID":32342,"DIRECTION":"BI","MASTER_ID":32339,"metacyc":"RXN-12956","compounds":"(+)-thujan-3-ol + NADP(+) <=> (+)-thujan-3-one + H(+) + NADPH","pmd":591.963}
{"X":6516,"KEGG":"R09987","RHEA_ID":32342,"DIRECTION":"BI","MASTER_ID":32339,"metacyc":"RXN-12956","compounds":"(+)-thujan-3-ol + NADP(+) <=> (+)-thujan-3-one + H(+) + NADPH","pmd":2.016}
{"X":6517,"KEGG":"R09987","RHEA_ID":32502,"DIRECTION":"BI","MASTER_ID":32499,"compounds":"(1R,5R)-sabinene + H(+) + NADPH + O2 <=> (1S,3R,5S)-sabinol + H2O + NADP(+)","pmd":591.963}
{"X":6518,"KEGG":"R09987","RHEA_ID":32502,"DIRECTION":"BI","MASTER_ID":32499,"compounds":"(1R,5R)-sabinene + H(+) + NADPH + O2 <=> (1S,3R,5S)-sabinol + H2O + NADP(+)","pmd":2.016}
{"X":6519,"KEGG":"R09988","RHEA_ID":32330,"DIRECTION":"BI","MASTER_ID":32327,"compounds":"10-hydroxy-alpha-humulene + NAD(+) <=> H(+) + NADH + zerumbone","pmd":445.95}
{"X":6520,"KEGG":"R09988","RHEA_ID":32330,"DIRECTION":"BI","MASTER_ID":32327,"compounds":"10-hydroxy-alpha-humulene + NAD(+) <=> H(+) + NADH + zerumbone","pmd":2.016}
{"X":6521,"KEGG":"R09989","RHEA_ID":32622,"DIRECTION":"BI","MASTER_ID":32619,"metacyc":"RXN-13222","compounds":"L-threo-7,8-dihydrobiopterin + NADP(+) <=> H(+) + NADPH + sepiapterin","pmd":2.016}
{"X":6522,"KEGG":"R09989","RHEA_ID":32622,"DIRECTION":"BI","MASTER_ID":32619,"metacyc":"RXN-13222","compounds":"L-threo-7,8-dihydrobiopterin + NADP(+) <=> H(+) + NADPH + sepiapterin","pmd":506.997}
{"X":6523,"KEGG":"R09990","RHEA_ID":32626,"DIRECTION":"BI","MASTER_ID":32623,"compounds":"L-threo-tetrahydrobiopterin + 2 NADP(+) <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH","pmd":4.031}
{"X":6524,"KEGG":"R09990","RHEA_ID":32626,"DIRECTION":"BI","MASTER_ID":32623,"compounds":"L-threo-tetrahydrobiopterin + 2 NADP(+) <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH","pmd":506.997}
{"X":6525,"KEGG":"R09993","RHEA_ID":31802,"DIRECTION":"BI","MASTER_ID":31799,"compounds":"4-amino-5-aminomethyl-2-methylpyrimidine + H2O <=> 4-amino-5-hydroxymethyl-2-methylpyrimidine + NH4(+)","pmd":0.984}
{"X":6526,"KEGG":"R09994","RHEA_ID":42695,"DIRECTION":"BI","MASTER_ID":42692,"metacyc":"RXN-13028","compounds":"[(1->4)-alpha-D-glucosyl](n) + alpha-maltose 1-phosphate <=> [(1->4)-alpha-D-glucosyl](n+2) + phosphate"}
{"X":6527,"KEGG":"R09997","RHEA_ID":32670,"DIRECTION":"BI","MASTER_ID":32667,"metacyc":"RXN-13229","compounds":"coenzyme M + methanethiol <=> H(+) + hydrogen sulfide + methyl-coenzyme M","pmd":14.016}
{"X":6528,"KEGG":"R10000","RHEA_ID":45211,"DIRECTION":"BI","MASTER_ID":45208,"metacyc":"RXN-8096","compounds":"[methyl-Co(III) methanol-specific corrinoid protein] + coenzyme M <=> [Co(I) methanol-specific corrinoid protein] + H(+) + methyl-coenzyme M","pmd":14.016}
{"X":6529,"KEGG":"R10000","RHEA_ID":47195,"DIRECTION":"BI","MASTER_ID":47192,"compounds":"[methyl-Co(III) methylated-thiol-specific corrinoid protein] + coenzyme M <=> [Co(I) methylated-thiol-specific corrinoid protein] + H(+) + methyl-coenzyme M","pmd":14.016}
{"X":6530,"KEGG":"R10000","RHEA_ID":60579,"DIRECTION":"BI","MASTER_ID":60576,"compounds":"[methyl-Co(III) tetramethylammonium-specific corrinoid protein] + coenzyme M <=> [Co(I) tetramethylammonium-specific corrinoid protein] + H(+) + methyl-coenzyme M","pmd":14.016}
{"X":6531,"KEGG":"R10001","RHEA_ID":47191,"DIRECTION":"BI","MASTER_ID":47188,"compounds":"[Co(I) methylated-thiol-specific corrinoid protein] + methanethiol <=> [methyl-Co(III) methylated-thiol-specific corrinoid protein] + hydrogen sulfide"}
{"X":6532,"KEGG":"R10003","RHEA_ID":33422,"DIRECTION":"BI","MASTER_ID":33419,"compounds":"[(1R)-2,2,3-trimethyl-2-oxocyclopent-3-en-1-yl]acetate + ATP + CoA <=> [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + AMP + diphosphate","pmd":159.933}
{"X":6533,"KEGG":"R10003","RHEA_ID":33422,"DIRECTION":"BI","MASTER_ID":33419,"compounds":"[(1R)-2,2,3-trimethyl-2-oxocyclopent-3-en-1-yl]acetate + ATP + CoA <=> [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + AMP + diphosphate","pmd":164.969}
{"X":6534,"KEGG":"R10003","RHEA_ID":33422,"DIRECTION":"BI","MASTER_ID":33419,"compounds":"[(1R)-2,2,3-trimethyl-2-oxocyclopent-3-en-1-yl]acetate + ATP + CoA <=> [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + AMP + diphosphate","pmd":164.084}
{"X":6535,"KEGG":"R10004","RHEA_ID":33106,"DIRECTION":"BI","MASTER_ID":33103,"compounds":"(2E,6E)-farnesyl diphosphate <=> alpha-muurolene + diphosphate","pmd":177.943}
{"X":6536,"KEGG":"R10005","RHEA_ID":33110,"DIRECTION":"BI","MASTER_ID":33107,"compounds":"(2E,6E)-farnesyl diphosphate <=> diphosphate + gamma-muurolene","pmd":177.943}
{"X":6537,"KEGG":"R10006","RHEA_ID":33114,"DIRECTION":"BI","MASTER_ID":33111,"compounds":"(2E,6E)-farnesyl diphosphate <=> beta-copaene + diphosphate","pmd":177.943}
{"X":6538,"KEGG":"R10007","RHEA_ID":32022,"DIRECTION":"BI","MASTER_ID":32019,"compounds":"(2E,6E)-farnesyl diphosphate <=> beta-cubebene + diphosphate","pmd":177.943}
{"X":6539,"KEGG":"R10008","RHEA_ID":33122,"DIRECTION":"BI","MASTER_ID":33119,"compounds":"(2E,6E)-farnesyl diphosphate <=> (+)-sativene + diphosphate","pmd":177.943}
{"X":6540,"KEGG":"R10009","RHEA_ID":33126,"DIRECTION":"BI","MASTER_ID":33123,"compounds":"all-trans-heptaprenyl diphosphate <=> diphosphate + tetraprenyl-beta-curcumene","pmd":177.943}
{"X":6541,"KEGG":"R10010","RHEA_ID":32762,"DIRECTION":"BI","MASTER_ID":32759,"compounds":"L-lysine <=> (3R)-3-methyl-D-ornithine","pmd":0}
{"X":6542,"KEGG":"R10014","RHEA_ID":26062,"DIRECTION":"BI","MASTER_ID":26059,"compounds":"[Co(I) methylamine-specific corrinoid protein] + H(+) + methylamine <=> [methyl-Co(III) methylamine-specific corrinoid protein] + NH4(+)"}
{"X":6543,"KEGG":"R10015","RHEA_ID":41178,"DIRECTION":"BI","MASTER_ID":41175,"compounds":"[Co(I) dimethylamine-specific corrinoid protein] + dimethylamine + H(+) <=> [methyl-Co(III) dimethylamine-specific corrinoid protein] + methylamine"}
{"X":6544,"KEGG":"R10016","RHEA_ID":39290,"DIRECTION":"BI","MASTER_ID":39287,"compounds":"[Co(I) trimethylamine-specific corrinoid protein] + H(+) + trimethylamine <=> [methyl-Co(III) trimethylamine-specific corrinoid protein] + dimethylamine"}
{"X":6545,"KEGG":"R10017","RHEA_ID":59859,"DIRECTION":"BI","MASTER_ID":59856,"compounds":"[Co(I) tetramethylammonium-specific corrinoid protein] + H(+) + tetramethylammonium <=> [methyl-Co(III) tetramethylammonium-specific corrinoid protein] + trimethylamine"}
{"X":6546,"KEGG":"R10020","RHEA_ID":57407,"DIRECTION":"BI","MASTER_ID":57404,"compounds":"NAD(+) + narcotine hemiacetal <=> H(+) + NADH + noscapine","pmd":2.016}
{"X":6547,"KEGG":"R10020","RHEA_ID":57407,"DIRECTION":"BI","MASTER_ID":57404,"compounds":"NAD(+) + narcotine hemiacetal <=> H(+) + NADH + noscapine","pmd":250.969}
{"X":6548,"KEGG":"R10021","RHEA_ID":32882,"DIRECTION":"BI","MASTER_ID":32879,"compounds":"(1R,4R,5R)-5-hydroxycamphor + NAD(+) <=> (1R,4R)-bornane-2,5-dione + H(+) + NADH","pmd":498.017}
{"X":6549,"KEGG":"R10021","RHEA_ID":32882,"DIRECTION":"BI","MASTER_ID":32879,"compounds":"(1R,4R,5R)-5-hydroxycamphor + NAD(+) <=> (1R,4R)-bornane-2,5-dione + H(+) + NADH","pmd":2.016}
{"X":6550,"KEGG":"R10022","RHEA_ID":33926,"DIRECTION":"BI","MASTER_ID":33923,"compounds":"(1R,4R)-5-oxo-1,2-campholide <=> [(1R)-2,2,3-trimethyl-2-oxocyclopent-3-en-1-yl]acetate + H(+)","pmd":0}
{"X":6551,"KEGG":"R10023","RHEA_ID":33006,"DIRECTION":"BI","MASTER_ID":33003,"compounds":"(+)-amorpha-4,11-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-artemisinic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":6552,"KEGG":"R10024","RHEA_ID":33010,"DIRECTION":"BI","MASTER_ID":33007,"compounds":"(+)-artemisinic alcohol + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-artemisinic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]","pmd":2.016}
{"X":6553,"KEGG":"R10025","RHEA_ID":33014,"DIRECTION":"BI","MASTER_ID":33011,"compounds":"(+)-artemisinic aldehyde + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-artemisinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":6554,"KEGG":"R10026","RHEA_ID":33002,"DIRECTION":"BI","MASTER_ID":32999,"compounds":"(+)-amorpha-4,11-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> (+)-artemisinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]","pmd":29.974}
{"X":6555,"KEGG":"R10027","RHEA_ID":30482,"DIRECTION":"BI","MASTER_ID":30479,"compounds":"L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":6556,"KEGG":"R10028","RHEA_ID":30486,"DIRECTION":"BI","MASTER_ID":30483,"compounds":"N-hydroxy-L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":6557,"KEGG":"R10029","RHEA_ID":30490,"DIRECTION":"BI","MASTER_ID":30487,"compounds":"H(+) + N,N-dihydroxy-L-isoleucine <=> (1E,2S)-2-methylbutanal oxime + CO2 + H2O","pmd":62}
{"X":6558,"KEGG":"R10030","RHEA_ID":51943,"DIRECTION":"BI","MASTER_ID":51940,"compounds":"(1E,2S)-2-methylbutanal oxime <=> (1Z,2S)-2-methylbutanal oxime","pmd":0}
{"X":6559,"KEGG":"R10031","RHEA_ID":30494,"DIRECTION":"BI","MASTER_ID":30491,"compounds":"L-valine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-valine + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":6560,"KEGG":"R10032","RHEA_ID":30498,"DIRECTION":"BI","MASTER_ID":30495,"compounds":"N-hydroxy-L-valine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-valine + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":6561,"KEGG":"R10033","RHEA_ID":30502,"DIRECTION":"BI","MASTER_ID":30499,"compounds":"H(+) + N,N-dihydroxy-L-valine <=> (E)-2-methylpropanal oxime + CO2 + H2O"}
{"X":6562,"KEGG":"R10034","RHEA_ID":51959,"DIRECTION":"BI","MASTER_ID":51956,"compounds":"(E)-2-methylpropanal oxime <=> (Z)-2-methylpropanal oxime"}
{"X":6563,"KEGG":"R10041","RHEA_ID":52163,"DIRECTION":"BI","MASTER_ID":52160,"compounds":"(E)-phenylacetaldehyde oxime <=> (Z)-phenylacetaldehyde oxime","pmd":0}
{"X":6564,"KEGG":"R10043","RHEA_ID":57955,"DIRECTION":"BI","MASTER_ID":57952,"compounds":"H(+) + NADH + O2 + phenol <=> catechol + H2O + NAD(+)","pmd":555.088}
{"X":6565,"KEGG":"R10044","RHEA_ID":33018,"DIRECTION":"BI","MASTER_ID":33015,"compounds":"[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + H(+) + NADPH + O2 <=> [(2R)-3,3,4-trimethyl-6-oxo-3,6-dihydro-1H-pyran-2-yl]acetyl-CoA + H2O + NADP(+)","pmd":15.995}
{"X":6566,"KEGG":"R10044","RHEA_ID":33018,"DIRECTION":"BI","MASTER_ID":33015,"compounds":"[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + H(+) + NADPH + O2 <=> [(2R)-3,3,4-trimethyl-6-oxo-3,6-dihydro-1H-pyran-2-yl]acetyl-CoA + H2O + NADP(+)","pmd":202.103}
{"X":6567,"KEGG":"R10045","RHEA_ID":33046,"DIRECTION":"BI","MASTER_ID":33043,"compounds":"(1R,4R)-camphor + H(+) + NADPH + O2 <=> (+)-6-exo-hydroxycamphor + H2O + NADP(+)","pmd":15.995}
{"X":6568,"KEGG":"R10045","RHEA_ID":33046,"DIRECTION":"BI","MASTER_ID":33043,"compounds":"(1R,4R)-camphor + H(+) + NADPH + O2 <=> (+)-6-exo-hydroxycamphor + H2O + NADP(+)","pmd":576.976}
{"X":6569,"KEGG":"R10047","RHEA_ID":33050,"DIRECTION":"BI","MASTER_ID":33047,"compounds":"(1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin] <=> (+)-6-endo-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin]","pmd":15.995}
{"X":6570,"KEGG":"R10048","RHEA_ID":33066,"DIRECTION":"BI","MASTER_ID":33063,"metacyc":"RXN-13138","compounds":"H(+) + NAD(+) + 2 reduced [2Fe-2S]-[putidaredoxin] <=> NADH + 2 oxidized [2Fe-2S]-[putidaredoxin]"}
{"X":6571,"KEGG":"R10049","RHEA_ID":31914,"DIRECTION":"BI","MASTER_ID":31911,"compounds":"beta-D-fructose 1,6-bisphosphate + methylglyoxal <=> 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde 3-phosphate","pmd":97.977}
{"X":6572,"KEGG":"R10050","RHEA_ID":32262,"DIRECTION":"BI","MASTER_ID":32259,"metacyc":"RXN-13144","compounds":"beta-D-fructose 1-phosphate + methylglyoxal <=> 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde","pmd":18.01}
{"X":6573,"KEGG":"R10051","RHEA_ID":33418,"DIRECTION":"BI","MASTER_ID":33415,"metacyc":"RXN-13332","compounds":"bornane-2,6-dione + H2O <=> [(1S)-4-hydroxy-2,2,3-trimethylcyclopent-3-enyl]acetate + H(+)","pmd":18.011}
{"X":6574,"KEGG":"R10052","RHEA_ID":32274,"DIRECTION":"BI","MASTER_ID":32271,"compounds":"(2R,3S)-3-isopropylmalate + NAD(+) <=> 4-methyl-2-oxopentanoate + CO2 + NADH","pmd":46.006}
{"X":6575,"KEGG":"R10052","RHEA_ID":32274,"DIRECTION":"BI","MASTER_ID":32271,"compounds":"(2R,3S)-3-isopropylmalate + NAD(+) <=> 4-methyl-2-oxopentanoate + CO2 + NADH","pmd":534.054}
{"X":6576,"KEGG":"R10053","RHEA_ID":32366,"DIRECTION":"BI","MASTER_ID":32363,"compounds":"L-gulono-1,4-lactone + O2 <=> H(+) + H2O2 + L-ascorbate","pmd":2.016}
{"X":6577,"KEGG":"R10054","RHEA_ID":12411,"DIRECTION":"BI","MASTER_ID":12408,"metacyc":"LYSINE-6-DEHYDROGENASE-RXN","compounds":"L-lysine + NAD(+) <=> 2 H(+) + L-1-piperideine-6-carboxylate + NADH + NH4(+)","pmd":537.054}
{"X":6578,"KEGG":"R10054","RHEA_ID":12411,"DIRECTION":"BI","MASTER_ID":12408,"metacyc":"LYSINE-6-DEHYDROGENASE-RXN","compounds":"L-lysine + NAD(+) <=> 2 H(+) + L-1-piperideine-6-carboxylate + NADH + NH4(+)","pmd":19.042}
{"X":6579,"KEGG":"R10055","RHEA_ID":32374,"DIRECTION":"BI","MASTER_ID":32371,"metacyc":"RXN-13185","compounds":"all-trans-violaxanthin + 2 L-ascorbate <=> all-trans-zeaxanthin + 2 H2O + 2 L-dehydroascorbate","pmd":31.99}
{"X":6580,"KEGG":"R10055","RHEA_ID":32374,"DIRECTION":"BI","MASTER_ID":32371,"metacyc":"RXN-13185","compounds":"all-trans-violaxanthin + 2 L-ascorbate <=> all-trans-zeaxanthin + 2 H2O + 2 L-dehydroascorbate","pmd":2.016}
{"X":6581,"KEGG":"R10056","RHEA_ID":42035,"DIRECTION":"BI","MASTER_ID":42032,"compounds":"2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 O2 <=> 2 CO2 + 2 formaldehyde + L-lysyl(36)-[histone H3] + 2 succinate","pmd":27.995}
{"X":6582,"KEGG":"R10056","RHEA_ID":10787,"DIRECTION":"BI","MASTER_ID":10784,"compounds":"2-oxoglutarate + N(6)-methyl-L-lysyl(36)-[histone H3] + O2 <=> CO2 + formaldehyde + L-lysyl(36)-[histone H3] + succinate","pmd":27.995}
{"X":6583,"KEGG":"R10057","RHEA_ID":55223,"DIRECTION":"BI","MASTER_ID":55220,"compounds":"4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 <=> 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate + 6 [Fe(III)-cytochrome b5] + 4 H2O","pmd":29.974}
{"X":6584,"KEGG":"R10059","RHEA_ID":32482,"DIRECTION":"BI","MASTER_ID":32479,"compounds":"2 iodide + L-tyrosine + 2 NADP(+) <=> 3,5-diiodo-L-tyrosine + H(+) + 2 NADPH","pmd":311.216}
{"X":6585,"KEGG":"R10059","RHEA_ID":32482,"DIRECTION":"BI","MASTER_ID":32479,"compounds":"2 iodide + L-tyrosine + 2 NADP(+) <=> 3,5-diiodo-L-tyrosine + H(+) + 2 NADPH","pmd":251.793}
{"X":6586,"KEGG":"R10060","RHEA_ID":32466,"DIRECTION":"BI","MASTER_ID":32463,"compounds":"glycine + 2 S-adenosyl-L-methionine <=> 2 H(+) + N,N-dimethylglycine + 2 S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6587,"KEGG":"R10061","RHEA_ID":32470,"DIRECTION":"BI","MASTER_ID":32467,"compounds":"2 S-adenosyl-L-methionine + sarcosine <=> betaine + 2 H(+) + 2 S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6588,"KEGG":"R10062","RHEA_ID":32478,"DIRECTION":"BI","MASTER_ID":32475,"compounds":"glycine + 3 S-adenosyl-L-methionine <=> betaine + 3 H(+) + 3 S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6589,"KEGG":"R10063","RHEA_ID":32358,"DIRECTION":"BI","MASTER_ID":32355,"compounds":"delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + 2 UDP-alpha-D-glucose <=> 2 H(+) + ternatin C5 + 2 UDP","pmd":147.101}
{"X":6590,"KEGG":"R10063","RHEA_ID":32358,"DIRECTION":"BI","MASTER_ID":32355,"compounds":"delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + 2 UDP-alpha-D-glucose <=> 2 H(+) + ternatin C5 + 2 UDP","pmd":162.053}
{"X":6591,"KEGG":"R10064","RHEA_ID":12271,"DIRECTION":"BI","MASTER_ID":12268,"ecocyc":"2.6.1.82-RXN","metacyc":"2.6.1.82-RXN","compounds":"2-oxoglutarate + putrescine <=> 1-pyrroline + H2O + L-glutamate","pmd":1.032}
{"X":6592,"KEGG":"R10065","RHEA_ID":32362,"DIRECTION":"BI","MASTER_ID":32359,"metacyc":"RXN-13197","compounds":"1D-myo-inositol 1,4,5-trisphosphate + 2 ATP <=> 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+)","pmd":72.899}
{"X":6593,"KEGG":"R10065","RHEA_ID":32362,"DIRECTION":"BI","MASTER_ID":32359,"metacyc":"RXN-13197","compounds":"1D-myo-inositol 1,4,5-trisphosphate + 2 ATP <=> 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+)","pmd":7.067}
{"X":6594,"KEGG":"R10066","RHEA_ID":32326,"DIRECTION":"BI","MASTER_ID":32323,"compounds":"ent-kaur-16-ene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> ent-kaur-16-en-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]","pmd":29.974}
{"X":6595,"KEGG":"R10067","RHEA_ID":33222,"DIRECTION":"BI","MASTER_ID":33219,"compounds":"ent-kaur-16-en-19-oate + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> gibberellin A12 + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]","pmd":29.974}
{"X":6596,"KEGG":"R10068","RHEA_ID":33238,"DIRECTION":"BI","MASTER_ID":33235,"compounds":"2 H(+) + Mg-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 O2 <=> 3,8-divinyl protochlorophyllide a + 5 H2O + 3 NADP(+)","pmd":11.964}
{"X":6597,"KEGG":"R10068","RHEA_ID":33238,"DIRECTION":"BI","MASTER_ID":33235,"compounds":"2 H(+) + Mg-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 O2 <=> 3,8-divinyl protochlorophyllide a + 5 H2O + 3 NADP(+)","pmd":134.884}
{"X":6598,"KEGG":"R10069","RHEA_ID":55451,"DIRECTION":"BI","MASTER_ID":55448,"compounds":"a 3',5'-unsubstituted flavanone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> a 3',5'-dihydroxyflavanone + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]","pmd":31.99}
{"X":6599,"KEGG":"R10071","RHEA_ID":32446,"DIRECTION":"BI","MASTER_ID":32443,"compounds":"all-trans-zeaxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> all-trans-violaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":6600,"KEGG":"R10072","RHEA_ID":32442,"DIRECTION":"BI","MASTER_ID":32439,"compounds":"(+)-epi-isozizaene + 2 H(+) + 2 NADPH + 2 O2 <=> albaflavenone + 3 H2O + 2 NADP(+)","pmd":13.979}
{"X":6601,"KEGG":"R10072","RHEA_ID":32442,"DIRECTION":"BI","MASTER_ID":32439,"compounds":"(+)-epi-isozizaene + 2 H(+) + 2 NADPH + 2 O2 <=> albaflavenone + 3 H2O + 2 NADP(+)","pmd":526.924}
{"X":6602,"KEGG":"R10073","RHEA_ID":32458,"DIRECTION":"BI","MASTER_ID":32455,"compounds":"(-)-vetispiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + solavetivone","pmd":13.979}
{"X":6603,"KEGG":"R10074","RHEA_ID":20592,"DIRECTION":"BI","MASTER_ID":20589,"metacyc":"GLUTARYL-COA-DEHYDROG-RXN","compounds":"glutaryl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-glutaconyl-CoA + reduced [electron-transfer flavoprotein]","pmd":2.016}
{"X":6604,"KEGG":"R10075","RHEA_ID":32886,"DIRECTION":"BI","MASTER_ID":32883,"compounds":"(11R)-dihydroartemisinic aldehyde + NADP(+) <=> (+)-artemisinic aldehyde + H(+) + NADPH","pmd":2.016}
{"X":6605,"KEGG":"R10075","RHEA_ID":32886,"DIRECTION":"BI","MASTER_ID":32883,"compounds":"(11R)-dihydroartemisinic aldehyde + NADP(+) <=> (+)-artemisinic aldehyde + H(+) + NADPH","pmd":525.916}
{"X":6606,"KEGG":"R10076","RHEA_ID":32898,"DIRECTION":"BI","MASTER_ID":32895,"compounds":"1,8-cineole + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-exo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":6607,"KEGG":"R10077","RHEA_ID":31986,"DIRECTION":"BI","MASTER_ID":31983,"compounds":"abieta-7,13-dien-18-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> abieta-7,13-dien-18,18-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":6608,"KEGG":"R10078","RHEA_ID":32198,"DIRECTION":"BI","MASTER_ID":32195,"compounds":"abieta-7,13-dien-18,18-diol <=> abieta-7,13-dien-18-al + H2O","pmd":18.011}
{"X":6609,"KEGG":"R10080","RHEA_ID":30362,"DIRECTION":"BI","MASTER_ID":30359,"compounds":"chlorophyllide a + 2 H(+) + 2 NADPH + 2 O2 <=> chlorophyllide b + 3 H2O + 2 NADP(+)","pmd":116.874}
{"X":6610,"KEGG":"R10080","RHEA_ID":30362,"DIRECTION":"BI","MASTER_ID":30359,"compounds":"chlorophyllide a + 2 H(+) + 2 NADPH + 2 O2 <=> chlorophyllide b + 3 H2O + 2 NADP(+)","pmd":13.979}
{"X":6611,"KEGG":"R10081","RHEA_ID":31534,"DIRECTION":"BI","MASTER_ID":31531,"compounds":"2-oxoglutarate + L-arginine + O2 <=> CO2 + N(omega)-hydroxy-L-arginine + succinate","pmd":27.995}
{"X":6612,"KEGG":"R10081","RHEA_ID":31534,"DIRECTION":"BI","MASTER_ID":31531,"compounds":"2-oxoglutarate + L-arginine + O2 <=> CO2 + N(omega)-hydroxy-L-arginine + succinate","pmd":15.995}
{"X":6613,"KEGG":"R10082","RHEA_ID":31530,"DIRECTION":"BI","MASTER_ID":31527,"compounds":"N(omega)-hydroxy-L-arginine <=> (S)-1-pyrroline-5-carboxylate + guanidine + H(+) + H2O","pmd":77.059}
{"X":6614,"KEGG":"R10086","RHEA_ID":32194,"DIRECTION":"BI","MASTER_ID":32191,"compounds":"H2O + L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2-oxoglutarate + 2 H(+) + NH4(+) + 2 reduced [2Fe-2S]-[ferredoxin]","pmd":1.032}
{"X":6615,"KEGG":"R10088","RHEA_ID":26408,"DIRECTION":"BI","MASTER_ID":26405,"compounds":"aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH4(+) <=> H(+) + 4 H2O + phosphate + pyridoxal 5'-phosphate","pmd":17.005}
{"X":6616,"KEGG":"R10088","RHEA_ID":26408,"DIRECTION":"BI","MASTER_ID":26405,"compounds":"aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH4(+) <=> H(+) + 4 H2O + phosphate + pyridoxal 5'-phosphate","pmd":77.027}
{"X":6617,"KEGG":"R10089","RHEA_ID":31510,"DIRECTION":"BI","MASTER_ID":31507,"compounds":"aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine <=> H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate","pmd":22.945}
{"X":6618,"KEGG":"R10089","RHEA_ID":31510,"DIRECTION":"BI","MASTER_ID":31507,"compounds":"aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine <=> H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate","pmd":0.984}
{"X":6619,"KEGG":"R10089","RHEA_ID":31510,"DIRECTION":"BI","MASTER_ID":31507,"compounds":"aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine <=> H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate","pmd":17.005}
{"X":6620,"KEGG":"R10090","RHEA_ID":32166,"DIRECTION":"BI","MASTER_ID":32163,"compounds":"ATP + citrate + N(6)-acetyl-N(6)-hydroxy-L-lysine <=> AMP + diphosphate + H(+) + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine","pmd":142.952}
{"X":6621,"KEGG":"R10090","RHEA_ID":32166,"DIRECTION":"BI","MASTER_ID":32163,"compounds":"ATP + citrate + N(6)-acetyl-N(6)-hydroxy-L-lysine <=> AMP + diphosphate + H(+) + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine","pmd":128.868}
{"X":6622,"KEGG":"R10090","RHEA_ID":32166,"DIRECTION":"BI","MASTER_ID":32163,"compounds":"ATP + citrate + N(6)-acetyl-N(6)-hydroxy-L-lysine <=> AMP + diphosphate + H(+) + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine","pmd":155.036}
{"X":6623,"KEGG":"R10091","RHEA_ID":32170,"DIRECTION":"BI","MASTER_ID":32167,"compounds":"ATP + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine + N(6)-acetyl-N(6)-hydroxy-L-lysine <=> aerobactin + AMP + diphosphate + H(+)","pmd":31.064}
{"X":6624,"KEGG":"R10091","RHEA_ID":32170,"DIRECTION":"BI","MASTER_ID":32167,"compounds":"ATP + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine + N(6)-acetyl-N(6)-hydroxy-L-lysine <=> aerobactin + AMP + diphosphate + H(+)","pmd":142.952}
{"X":6625,"KEGG":"R10091","RHEA_ID":32170,"DIRECTION":"BI","MASTER_ID":32167,"compounds":"ATP + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine + N(6)-acetyl-N(6)-hydroxy-L-lysine <=> aerobactin + AMP + diphosphate + H(+)","pmd":57.232}
{"X":6626,"KEGG":"R10093","RHEA_ID":33966,"DIRECTION":"BI","MASTER_ID":33963,"compounds":"ATP + isopentenyl phosphate <=> ADP + isopentenyl diphosphate","pmd":79.966}
{"X":6627,"KEGG":"R10094","RHEA_ID":34302,"DIRECTION":"BI","MASTER_ID":34299,"metacyc":"RXN-13127","compounds":"2'-deamino-2'-hydroxyneamine + 2-oxoglutarate <=> 2'-deamino-2'-hydroxy-6'-dehydroparomamine + L-glutamate","pmd":1.032}
{"X":6628,"KEGG":"R10095","RHEA_ID":34070,"DIRECTION":"BI","MASTER_ID":34067,"compounds":"5-phospho-alpha-D-ribose 1-diphosphate + H(+) + trans,octa-cis-decaprenyl phosphate <=> diphosphate + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose 5-phosphate","pmd":212.009}
{"X":6629,"KEGG":"R10095","RHEA_ID":34070,"DIRECTION":"BI","MASTER_ID":34067,"compounds":"5-phospho-alpha-D-ribose 1-diphosphate + H(+) + trans,octa-cis-decaprenyl phosphate <=> diphosphate + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose 5-phosphate","pmd":600.66}
{"X":6630,"KEGG":"R10096","RHEA_ID":34066,"DIRECTION":"BI","MASTER_ID":34063,"compounds":"2-deoxystreptamine + UDP-alpha-D-glucose <=> 2'-deamino-2'-hydroxyparomamine + H(+) + UDP","pmd":162.053}
{"X":6631,"KEGG":"R10098","RHEA_ID":34210,"DIRECTION":"BI","MASTER_ID":34207,"metacyc":"RXN-13075","compounds":"3-O-alpha-D-glucopyranosyl-L-rhamnose + phosphate <=> beta-D-glucose 1-phosphate + L-rhamnopyranose","pmd":66.092}
{"X":6632,"KEGG":"R10099","RHEA_ID":34162,"DIRECTION":"BI","MASTER_ID":34159,"compounds":"acetyl-CoA + UDP-N-acetylbacillosamine <=> CoA + H(+) + UDP-N,N'-diacetylbacillosamine","pmd":42.011}
{"X":6633,"KEGG":"R10100","RHEA_ID":33590,"DIRECTION":"BI","MASTER_ID":33587,"compounds":"acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate <=> CoA + H(+) + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate","pmd":42.011}
{"X":6634,"KEGG":"R10101","RHEA_ID":33918,"DIRECTION":"BI","MASTER_ID":33915,"compounds":"4-(methylamino)butanoate + H2O + O2 <=> H2O2 + methylamine + succinate semialdehyde","pmd":15.047}
{"X":6635,"KEGG":"R10102","RHEA_ID":33910,"DIRECTION":"BI","MASTER_ID":33907,"compounds":"4-(methylamino)butanoate + H2O + O2 <=> 4-aminobutanoate + formaldehyde + H2O2","pmd":14.016}
{"X":6636,"KEGG":"R10103","RHEA_ID":33906,"DIRECTION":"BI","MASTER_ID":33903,"compounds":"H2O + O2 + pseudooxynicotine <=> 4-oxo-4-(pyridin-3-yl)butanal + H2O2 + methylamine","pmd":15.047}
{"X":6637,"KEGG":"R10104","RHEA_ID":52719,"DIRECTION":"BI","MASTER_ID":52716,"compounds":"a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH <=> a long-chain primary fatty alcohol + CoA + 2 NADP(+)","pmd":22.024}
{"X":6638,"KEGG":"R10105","RHEA_ID":34218,"DIRECTION":"BI","MASTER_ID":34215,"compounds":"4-oxo-4-(pyridin-3-yl)butanal + H2O + NADP(+) <=> 4-oxo-4-(pyridin-3-yl)butanoate + 2 H(+) + NADPH","pmd":565.025}
{"X":6639,"KEGG":"R10105","RHEA_ID":34218,"DIRECTION":"BI","MASTER_ID":34215,"compounds":"4-oxo-4-(pyridin-3-yl)butanal + H2O + NADP(+) <=> 4-oxo-4-(pyridin-3-yl)butanoate + 2 H(+) + NADPH","pmd":15.995}
{"X":6640,"KEGG":"R10106","RHEA_ID":33946,"DIRECTION":"BI","MASTER_ID":33943,"compounds":"H(+) + 2 L-arginine + 3 NADH + 4 O2 <=> 4 H2O + 2 L-citrulline + 3 NAD(+) + 2 nitric oxide","pmd":490.029}
{"X":6641,"KEGG":"R10106","RHEA_ID":33946,"DIRECTION":"BI","MASTER_ID":33943,"compounds":"H(+) + 2 L-arginine + 3 NADH + 4 O2 <=> 4 H2O + 2 L-citrulline + 3 NAD(+) + 2 nitric oxide","pmd":0.984}
{"X":6642,"KEGG":"R10109","RHEA_ID":34230,"DIRECTION":"BI","MASTER_ID":34227,"compounds":"5-nitrosalicylate + O2 <=> 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H(+) + nitrite","pmd":15.011}
{"X":6643,"KEGG":"R10110","RHEA_ID":34234,"DIRECTION":"BI","MASTER_ID":34231,"compounds":"5-nitrosalicylate + O2 <=> 4-nitro-6-oxohepta-2,4-dienedioate + H(+)","pmd":31.99}
{"X":6644,"KEGG":"R10111","RHEA_ID":34238,"DIRECTION":"BI","MASTER_ID":34235,"compounds":"4-nitro-6-oxohepta-2,4-dienedioate <=> 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + nitrite","pmd":47.001}
{"X":6645,"KEGG":"R10112","RHEA_ID":33902,"DIRECTION":"BI","MASTER_ID":33899,"compounds":"FAD + H(+) + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose <=> FADH2 + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose","pmd":2.016}
{"X":6646,"KEGG":"R10113","RHEA_ID":33898,"DIRECTION":"BI","MASTER_ID":33895,"compounds":"NAD(+) + trans,octa-cis-decaprenylphospho-beta-D-arabinofuranose <=> H(+) + NADH + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose","pmd":2.016}
{"X":6647,"KEGG":"R10113","RHEA_ID":33898,"DIRECTION":"BI","MASTER_ID":33895,"compounds":"NAD(+) + trans,octa-cis-decaprenylphospho-beta-D-arabinofuranose <=> H(+) + NADH + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose","pmd":244.513}
{"X":6648,"KEGG":"R10114","RHEA_ID":34214,"DIRECTION":"BI","MASTER_ID":34211,"metacyc":"RXN-13587","compounds":"ecgonine methyl ester + NADP(+) <=> ecgonone methyl ester + H(+) + NADPH","pmd":2.016}
{"X":6649,"KEGG":"R10114","RHEA_ID":34214,"DIRECTION":"BI","MASTER_ID":34211,"metacyc":"RXN-13587","compounds":"ecgonine methyl ester + NADP(+) <=> ecgonone methyl ester + H(+) + NADPH","pmd":546.978}
{"X":6650,"KEGG":"R10123","RHEA_ID":52975,"DIRECTION":"BI","MASTER_ID":52972,"compounds":"a C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] <=> a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin]"}
{"X":6651,"KEGG":"R10123","RHEA_ID":52855,"DIRECTION":"BI","MASTER_ID":52852,"compounds":"a C2-C8-saturated long-chain fatty acyl-[ACP] + 3 O2 + 2 reduced [flavodoxin] <=> 6-carboxyhexanoyl-[ACP] + a fatty aldehyde + 3 H(+) + 3 H2O + 2 oxidized [flavodoxin]"}
{"X":6652,"KEGG":"R10128","RHEA_ID":33894,"DIRECTION":"BI","MASTER_ID":33891,"compounds":"chanoclavine-I + NAD(+) <=> chanoclavine-I aldehyde + H(+) + NADH","pmd":2.016}
{"X":6653,"KEGG":"R10128","RHEA_ID":33894,"DIRECTION":"BI","MASTER_ID":33891,"compounds":"chanoclavine-I + NAD(+) <=> chanoclavine-I aldehyde + H(+) + NADH","pmd":409.975}
{"X":6654,"KEGG":"R10129","RHEA_ID":33890,"DIRECTION":"BI","MASTER_ID":33887,"metacyc":"RXN-13433","compounds":"(-)-secoisolariciresinol + 2 NAD(+) <=> (-)-matairesinol + 2 H(+) + 2 NADH","pmd":305.975}
{"X":6655,"KEGG":"R10129","RHEA_ID":33890,"DIRECTION":"BI","MASTER_ID":33887,"metacyc":"RXN-13433","compounds":"(-)-secoisolariciresinol + 2 NAD(+) <=> (-)-matairesinol + 2 H(+) + 2 NADH","pmd":4.031}
{"X":6656,"KEGG":"R10130","RHEA_ID":33882,"DIRECTION":"BI","MASTER_ID":33879,"compounds":"2-deoxy-scyllo-inosamine + NADP(+) <=> 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADPH","pmd":583.014}
{"X":6657,"KEGG":"R10130","RHEA_ID":33882,"DIRECTION":"BI","MASTER_ID":33879,"compounds":"2-deoxy-scyllo-inosamine + NADP(+) <=> 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADPH","pmd":2.016}
{"X":6658,"KEGG":"R10131","RHEA_ID":34026,"DIRECTION":"BI","MASTER_ID":34023,"compounds":"3,3'-bipyridine-2,2',5,5',6,6'-hexol + NAD(+) <=> (E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADH","pmd":2.016}
{"X":6659,"KEGG":"R10131","RHEA_ID":34026,"DIRECTION":"BI","MASTER_ID":34023,"compounds":"3,3'-bipyridine-2,2',5,5',6,6'-hexol + NAD(+) <=> (E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADH","pmd":414.094}
{"X":6660,"KEGG":"R10132","RHEA_ID":34030,"DIRECTION":"BI","MASTER_ID":34027,"compounds":"3,3'-bipyridine-2,2',5,5',6,6'-hexol + NADP(+) <=> (E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADPH","pmd":494.061}
{"X":6661,"KEGG":"R10132","RHEA_ID":34030,"DIRECTION":"BI","MASTER_ID":34027,"compounds":"3,3'-bipyridine-2,2',5,5',6,6'-hexol + NADP(+) <=> (E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADPH","pmd":2.016}
{"X":6662,"KEGG":"R10133","RHEA_ID":34274,"DIRECTION":"BI","MASTER_ID":34271,"compounds":"2-nitroimidazole + H2O <=> 1,3-dihydro-2H-imidazol-2-one + H(+) + nitrite"}
{"X":6663,"KEGG":"R10134","RHEA_ID":34182,"DIRECTION":"BI","MASTER_ID":34179,"compounds":"H2O + mycophenolic acid O-acyl-glucuronide <=> D-glucuronate + H(+) + mycophenolate","pmd":176.032}
{"X":6664,"KEGG":"R10135","RHEA_ID":33970,"DIRECTION":"BI","MASTER_ID":33967,"compounds":"2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H2O <=> 3-maleylpyruvate + H(+)","pmd":18.011}
{"X":6665,"KEGG":"R10136","RHEA_ID":52279,"DIRECTION":"BI","MASTER_ID":52276,"compounds":"(6S)-5,6,7,8-tetrahydrofolate + 4-hydroxy-3-methoxybenzoate <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4-dihydroxybenzoate","pmd":14.016}
{"X":6666,"KEGG":"R10137","RHEA_ID":34074,"DIRECTION":"BI","MASTER_ID":34071,"compounds":"trans,octa-cis-decaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine <=> N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol + UMP","pmd":454.567}
{"X":6667,"KEGG":"R10137","RHEA_ID":34074,"DIRECTION":"BI","MASTER_ID":34071,"compounds":"trans,octa-cis-decaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine <=> N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol + UMP","pmd":283.046}
{"X":6668,"KEGG":"R10140","RHEA_ID":33582,"DIRECTION":"BI","MASTER_ID":33579,"compounds":"NAD(+) + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate <=> H(+) + NADH + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate","pmd":45.072}
{"X":6669,"KEGG":"R10140","RHEA_ID":33582,"DIRECTION":"BI","MASTER_ID":33579,"compounds":"NAD(+) + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate <=> H(+) + NADH + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate","pmd":2.016}
{"X":6670,"KEGG":"R10141","RHEA_ID":33586,"DIRECTION":"BI","MASTER_ID":33583,"metacyc":"RXN-13596","compounds":"L-glutamate + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate <=> 2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate","pmd":1.032}
{"X":6671,"KEGG":"R10143","RHEA_ID":34586,"DIRECTION":"BI","MASTER_ID":34583,"compounds":"2-oxoglutarate + O2 + pentalenolactone D <=> CO2 + H2O + pentalenolactone E + succinate","pmd":27.995}
{"X":6672,"KEGG":"R10143","RHEA_ID":34586,"DIRECTION":"BI","MASTER_ID":34583,"compounds":"2-oxoglutarate + O2 + pentalenolactone D <=> CO2 + H2O + pentalenolactone E + succinate","pmd":2.016}
{"X":6673,"KEGG":"R10144","RHEA_ID":34590,"DIRECTION":"BI","MASTER_ID":34587,"compounds":"2-oxoglutarate + O2 + pentalenolactone E <=> CO2 + pentalenolactone F + succinate","pmd":27.995}
{"X":6674,"KEGG":"R10144","RHEA_ID":34590,"DIRECTION":"BI","MASTER_ID":34587,"compounds":"2-oxoglutarate + O2 + pentalenolactone E <=> CO2 + pentalenolactone F + succinate","pmd":15.995}
{"X":6675,"KEGG":"R10145","RHEA_ID":34582,"DIRECTION":"BI","MASTER_ID":34579,"compounds":"2 2-oxoglutarate + 2 O2 + pentalenolactone D <=> 2 CO2 + H2O + pentalenolactone F + 2 succinate","pmd":27.995}
{"X":6676,"KEGG":"R10145","RHEA_ID":34582,"DIRECTION":"BI","MASTER_ID":34579,"compounds":"2 2-oxoglutarate + 2 O2 + pentalenolactone D <=> 2 CO2 + H2O + pentalenolactone F + 2 succinate","pmd":13.979}
{"X":6677,"KEGG":"R10146","RHEA_ID":55319,"DIRECTION":"BI","MASTER_ID":55316,"compounds":"3 H2O + hydrogen sulfide + 3 NAD(+) <=> 4 H(+) + 3 NADH + sulfite"}
{"X":6678,"KEGG":"R10147","RHEA_ID":34174,"DIRECTION":"BI","MASTER_ID":34171,"ecocyc":"DIHYDRODIPICSYN-RXN","metacyc":"DIHYDRODIPICSYN-RXN","compounds":"L-aspartate 4-semialdehyde + pyruvate <=> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O","pmd":70.006}
{"X":6679,"KEGG":"R10153","RHEA_ID":34242,"DIRECTION":"BI","MASTER_ID":34239,"metacyc":"RXN-13569","compounds":"L-glutamate <=> 3-aminopentanedioate","pmd":0}
{"X":6680,"KEGG":"R10154","RHEA_ID":34638,"DIRECTION":"BI","MASTER_ID":34635,"compounds":"1-deoxy-11-oxopentalenate + H(+) + NADPH + O2 <=> H2O + NADP(+) + pentalenolactone D","pmd":480.955}
{"X":6681,"KEGG":"R10154","RHEA_ID":34638,"DIRECTION":"BI","MASTER_ID":34635,"compounds":"1-deoxy-11-oxopentalenate + H(+) + NADPH + O2 <=> H2O + NADP(+) + pentalenolactone D","pmd":15.995}
{"X":6682,"KEGG":"R10155","RHEA_ID":34642,"DIRECTION":"BI","MASTER_ID":34639,"compounds":"1-deoxy-11-oxopentalenate + H(+) + NADPH + O2 <=> H2O + NADP(+) + neopentalenolactone D","pmd":480.955}
{"X":6683,"KEGG":"R10155","RHEA_ID":34642,"DIRECTION":"BI","MASTER_ID":34639,"compounds":"1-deoxy-11-oxopentalenate + H(+) + NADPH + O2 <=> H2O + NADP(+) + neopentalenolactone D","pmd":15.995}
{"X":6684,"KEGG":"R10156","RHEA_ID":34562,"DIRECTION":"BI","MASTER_ID":34559,"compounds":"1-deoxy-11beta-hydroxypentalenate + NAD(+) <=> 1-deoxy-11-oxopentalenate + H(+) + NADH","pmd":415.976}
{"X":6685,"KEGG":"R10156","RHEA_ID":34562,"DIRECTION":"BI","MASTER_ID":34559,"compounds":"1-deoxy-11beta-hydroxypentalenate + NAD(+) <=> 1-deoxy-11-oxopentalenate + H(+) + NADH","pmd":2.016}
{"X":6686,"KEGG":"R10157","RHEA_ID":34622,"DIRECTION":"BI","MASTER_ID":34619,"compounds":"1-deoxypentalenate + 2-oxoglutarate + O2 <=> 1-deoxy-11beta-hydroxypentalenate + CO2 + succinate","pmd":15.995}
{"X":6687,"KEGG":"R10157","RHEA_ID":34622,"DIRECTION":"BI","MASTER_ID":34619,"compounds":"1-deoxypentalenate + 2-oxoglutarate + O2 <=> 1-deoxy-11beta-hydroxypentalenate + CO2 + succinate","pmd":27.995}
{"X":6688,"KEGG":"R10158","RHEA_ID":34502,"DIRECTION":"BI","MASTER_ID":34499,"compounds":"1-deoxypentalenate + 2 H(+) + O2 + reduced 2[4Fe-4S]-[ferredoxin] <=> H2O + oxidized 2[4Fe-4S]-[ferredoxin] + pentalenate","pmd":15.995}
{"X":6689,"KEGG":"R10159","RHEA_ID":42315,"DIRECTION":"BI","MASTER_ID":42312,"metacyc":"RXN-13685","compounds":"H(+) + NADP(+) + 2 reduced [adrenodoxin] <=> NADPH + 2 oxidized [adrenodoxin]"}
{"X":6690,"KEGG":"R10160","RHEA_ID":34414,"DIRECTION":"BI","MASTER_ID":34411,"compounds":"cannabigerolate + O2 <=> cannabidiolate + H2O2","pmd":2.016}
{"X":6691,"KEGG":"R10161","RHEA_ID":34474,"DIRECTION":"BI","MASTER_ID":34471,"compounds":"NAD(+) + propanoyl-CoA <=> acryloyl-CoA + H(+) + NADH","pmd":2.016}
{"X":6692,"KEGG":"R10161","RHEA_ID":34474,"DIRECTION":"BI","MASTER_ID":34471,"compounds":"NAD(+) + propanoyl-CoA <=> acryloyl-CoA + H(+) + NADH","pmd":157.009}
{"X":6693,"KEGG":"R10162","RHEA_ID":34578,"DIRECTION":"BI","MASTER_ID":34575,"compounds":"2 H(+) + O2 + pentalenolactone F + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalenolactone","pmd":2.016}
{"X":6694,"KEGG":"R10163","RHEA_ID":34058,"DIRECTION":"BI","MASTER_ID":34055,"compounds":"festuclavine + NAD(+) <=> 6,8-dimethyl-6,7-didehydroergoline + H(+) + NADH","pmd":424.962}
{"X":6695,"KEGG":"R10164","RHEA_ID":45035,"DIRECTION":"BI","MASTER_ID":45032,"compounds":"4 [Fe(III)cytochrome c] + H2O + hydroxylamine <=> 4 [Fe(II)cytochrome c] + 5 H(+) + nitrite"}
{"X":6696,"KEGG":"R10165","RHEA_ID":45039,"DIRECTION":"BI","MASTER_ID":45036,"compounds":"3 [Fe(III)cytochrome c] + hydroxylamine <=> 3 [Fe(II)cytochrome c] + 3 H(+) + nitric oxide"}
{"X":6697,"KEGG":"R10166","RHEA_ID":34438,"DIRECTION":"BI","MASTER_ID":34435,"compounds":"4-(3-methylbut-2-enyl)-L-tryptophan + S-adenosyl-L-methionine <=> 4-(3-methylbut-2-enyl)-L-abrine + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6698,"KEGG":"R10167","RHEA_ID":34650,"DIRECTION":"BI","MASTER_ID":34647,"compounds":"S-adenosyl-L-methionine + squalene <=> 3-methyl-1,2-didehydro-2,3-dihydrosqualene + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6699,"KEGG":"R10168","RHEA_ID":34654,"DIRECTION":"BI","MASTER_ID":34651,"compounds":"3-methyl-1,2-didehydro-2,3-dihydrosqualene + S-adenosyl-L-methionine <=> 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6700,"KEGG":"R10169","RHEA_ID":34646,"DIRECTION":"BI","MASTER_ID":34643,"compounds":"2 S-adenosyl-L-methionine + squalene <=> 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + 2 H(+) + 2 S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6701,"KEGG":"R10169","RHEA_ID":34646,"DIRECTION":"BI","MASTER_ID":34643,"compounds":"2 S-adenosyl-L-methionine + squalene <=> 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + 2 H(+) + 2 S-adenosyl-L-homocysteine","pmd":26.27}
{"X":6702,"KEGG":"R10170","RHEA_ID":32290,"DIRECTION":"BI","MASTER_ID":32287,"ecocyc":"RXN-13163","metacyc":"RXN-13163","compounds":"(2R,3S)-3-isopropylmalate <=> (2S)-2-isopropylmalate","pmd":0}
{"X":6703,"KEGG":"R10171","RHEA_ID":34122,"DIRECTION":"BI","MASTER_ID":34119,"metacyc":"RXN-7852","compounds":"3 H(+) + hexanoyl-CoA + 3 malonyl-CoA <=> 3,5,7-trioxododecanoyl-CoA + 3 CO2 + 3 CoA","pmd":86}
{"X":6704,"KEGG":"R10171","RHEA_ID":34122,"DIRECTION":"BI","MASTER_ID":34119,"metacyc":"RXN-7852","compounds":"3 H(+) + hexanoyl-CoA + 3 malonyl-CoA <=> 3,5,7-trioxododecanoyl-CoA + 3 CO2 + 3 CoA","pmd":98.073}
{"X":6705,"KEGG":"R10172","RHEA_ID":42267,"DIRECTION":"BI","MASTER_ID":42264,"compounds":"H(+) + malonyl-[ACP] + octanoyl-CoA <=> 3-oxodecanoyl-[ACP] + CO2 + CoA","pmd":126.105}
{"X":6706,"KEGG":"R10173","RHEA_ID":34178,"DIRECTION":"BI","MASTER_ID":34175,"compounds":"2-hydroxybenzoyl-CoA + malonyl-CoA <=> 4-hydroxycoumarin + CO2 + 2 CoA","pmd":86}
{"X":6707,"KEGG":"R10173","RHEA_ID":34178,"DIRECTION":"BI","MASTER_ID":34175,"compounds":"2-hydroxybenzoyl-CoA + malonyl-CoA <=> 4-hydroxycoumarin + CO2 + 2 CoA","pmd":120.021}
{"X":6708,"KEGG":"R10174","RHEA_ID":34534,"DIRECTION":"BI","MASTER_ID":34531,"compounds":"acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose <=> CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-glucose + H(+)","pmd":42.011}
{"X":6709,"KEGG":"R10175","RHEA_ID":34490,"DIRECTION":"BI","MASTER_ID":34487,"compounds":"dTDP-beta-L-rhamnose + N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol <=> alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + dTDP + H(+)","pmd":146.058}
{"X":6710,"KEGG":"R10176","RHEA_ID":34130,"DIRECTION":"BI","MASTER_ID":34127,"compounds":"(2E)-geranyl diphosphate + olivetolate <=> cannabigerolate + diphosphate","pmd":46.162}
{"X":6711,"KEGG":"R10176","RHEA_ID":34130,"DIRECTION":"BI","MASTER_ID":34127,"compounds":"(2E)-geranyl diphosphate + olivetolate <=> cannabigerolate + diphosphate","pmd":136.125}
{"X":6712,"KEGG":"R10177","RHEA_ID":34478,"DIRECTION":"BI","MASTER_ID":34475,"compounds":"2 all-trans-geranylgeranyl diphosphate <=> 15-cis-phytoene + 2 diphosphate","pmd":94.307}
{"X":6713,"KEGG":"R10178","RHEA_ID":32266,"DIRECTION":"BI","MASTER_ID":32263,"metacyc":"RXN-6902","compounds":"4-aminobutanoate + pyruvate <=> L-alanine + succinate semialdehyde","pmd":1.032}
{"X":6714,"KEGG":"R10179","RHEA_ID":32270,"DIRECTION":"BI","MASTER_ID":32267,"metacyc":"RXN-13328","compounds":"4-aminobutanoate + glyoxylate <=> glycine + succinate semialdehyde","pmd":1.032}
{"X":6715,"KEGG":"R10180","RHEA_ID":27589,"DIRECTION":"BI","MASTER_ID":27586,"metacyc":"RXN-10139","compounds":"L-tryptophan + pyruvate <=> indole-3-pyruvate + L-alanine","pmd":1.032}
{"X":6716,"KEGG":"R10181","RHEA_ID":34334,"DIRECTION":"BI","MASTER_ID":34331,"compounds":"H(+) + indole-3-pyruvate + NADPH + O2 <=> (indol-3-yl)acetate + CO2 + H2O + NADP(+)","pmd":27.995}
{"X":6717,"KEGG":"R10181","RHEA_ID":34334,"DIRECTION":"BI","MASTER_ID":34331,"compounds":"H(+) + indole-3-pyruvate + NADPH + O2 <=> (indol-3-yl)acetate + CO2 + H2O + NADP(+)","pmd":570.028}
{"X":6718,"KEGG":"R10182","RHEA_ID":34678,"DIRECTION":"BI","MASTER_ID":34675,"compounds":"CTP + N,N-diacetyllegionaminate <=> CMP-N,N-diacetyllegionaminate + diphosphate","pmd":305.041}
{"X":6719,"KEGG":"R10182","RHEA_ID":34678,"DIRECTION":"BI","MASTER_ID":34675,"compounds":"CTP + N,N-diacetyllegionaminate <=> CMP-N,N-diacetyllegionaminate + diphosphate","pmd":156.194}
{"X":6720,"KEGG":"R10183","RHEA_ID":34366,"DIRECTION":"BI","MASTER_ID":34363,"metacyc":"RXN-13760","compounds":"H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UTP <=> diphosphate + UDP-N-acetyl-alpha-D-galactosamine","pmd":123.113}
{"X":6721,"KEGG":"R10183","RHEA_ID":34366,"DIRECTION":"BI","MASTER_ID":34363,"metacyc":"RXN-13760","compounds":"H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UTP <=> diphosphate + UDP-N-acetyl-alpha-D-galactosamine","pmd":306.025}
{"X":6722,"KEGG":"R10184","RHEA_ID":34518,"DIRECTION":"BI","MASTER_ID":34515,"compounds":"tri-trans,hepta-cis-undecaprenyl phosphate + UDP-N,N'-diacetylbacillosamine <=> N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UMP","pmd":308.077}
{"X":6723,"KEGG":"R10184","RHEA_ID":34518,"DIRECTION":"BI","MASTER_ID":34515,"compounds":"tri-trans,hepta-cis-undecaprenyl phosphate + UDP-N,N'-diacetylbacillosamine <=> N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UMP","pmd":522.63}
{"X":6724,"KEGG":"R10187","RHEA_ID":34494,"DIRECTION":"BI","MASTER_ID":34491,"compounds":"H2O + UDP-N,N'-diacetylbacillosamine <=> 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H(+) + UDP","pmd":228.111}
{"X":6725,"KEGG":"R10187","RHEA_ID":46319,"DIRECTION":"BI","MASTER_ID":46316,"compounds":"GDP-N,N'-diacetylbacillosamine + H2O <=> 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + GDP + H(+)","pmd":228.111}
{"X":6726,"KEGG":"R10188","RHEA_ID":34514,"DIRECTION":"BI","MASTER_ID":34511,"compounds":"N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UDP-N-acetyl-alpha-D-galactosamine <=> H(+) + N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP","pmd":203.079}
{"X":6727,"KEGG":"R10189","RHEA_ID":34558,"DIRECTION":"BI","MASTER_ID":34555,"metacyc":"RXN-13927","compounds":"a (2S)-2-hydroxycarboxylate + NAD(+) <=> a 2-oxocarboxylate + H(+) + NADH"}
{"X":6728,"KEGG":"R10189","RHEA_ID":34558,"DIRECTION":"BI","MASTER_ID":34555,"metacyc":"RXN-15632","compounds":"a (2S)-2-hydroxycarboxylate + NAD(+) <=> a 2-oxocarboxylate + H(+) + NADH"}
{"X":6729,"KEGG":"R10190","RHEA_ID":34450,"DIRECTION":"BI","MASTER_ID":34447,"metacyc":"RXN-14184","compounds":"dTDP-6-deoxy-beta-L-talose + NAD(+) <=> dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADH","pmd":2.016}
{"X":6730,"KEGG":"R10190","RHEA_ID":34450,"DIRECTION":"BI","MASTER_ID":34447,"metacyc":"RXN-14184","compounds":"dTDP-6-deoxy-beta-L-talose + NAD(+) <=> dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADH","pmd":118.052}
{"X":6731,"KEGG":"R10191","RHEA_ID":34618,"DIRECTION":"BI","MASTER_ID":34615,"compounds":"2-hydroxyethylphosphonate + O2 <=> H(+) + hydrogencarbonate + methylphosphonate"}
{"X":6732,"KEGG":"R10192","RHEA_ID":33934,"DIRECTION":"BI","MASTER_ID":33931,"compounds":"all-trans-zeaxanthin + O2 <=> (3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal","pmd":268.219}
{"X":6733,"KEGG":"R10193","RHEA_ID":34262,"DIRECTION":"BI","MASTER_ID":34259,"compounds":"(+)-larreatricin + AH2 + O2 <=> (+)-3'-hydroxylarreatricin + A + H2O","pmd":15.995}
{"X":6734,"KEGG":"R10194","RHEA_ID":34574,"DIRECTION":"BI","MASTER_ID":34571,"compounds":"C30 botryococcene + diphosphate + NADP(+) <=> H(+) + NADPH + presqualene diphosphate","pmd":157.764}
{"X":6735,"KEGG":"R10194","RHEA_ID":34574,"DIRECTION":"BI","MASTER_ID":34571,"compounds":"C30 botryococcene + diphosphate + NADP(+) <=> H(+) + NADPH + presqualene diphosphate","pmd":175.928}
{"X":6736,"KEGG":"R10195","RHEA_ID":34662,"DIRECTION":"BI","MASTER_ID":34659,"compounds":"C30 botryococcene + S-adenosyl-L-methionine <=> 3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6737,"KEGG":"R10196","RHEA_ID":34674,"DIRECTION":"BI","MASTER_ID":34671,"compounds":"3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + S-adenosyl-L-methionine <=> 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6738,"KEGG":"R10197","RHEA_ID":34670,"DIRECTION":"BI","MASTER_ID":34667,"compounds":"C30 botryococcene + S-adenosyl-L-methionine <=> 20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6739,"KEGG":"R10198","RHEA_ID":34666,"DIRECTION":"BI","MASTER_ID":34663,"compounds":"20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + S-adenosyl-L-methionine <=> 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6740,"KEGG":"R10199","RHEA_ID":34658,"DIRECTION":"BI","MASTER_ID":34655,"compounds":"C30 botryococcene + 2 S-adenosyl-L-methionine <=> 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + 2 H(+) + 2 S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6741,"KEGG":"R10199","RHEA_ID":34658,"DIRECTION":"BI","MASTER_ID":34655,"compounds":"C30 botryococcene + 2 S-adenosyl-L-methionine <=> 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + 2 H(+) + 2 S-adenosyl-L-homocysteine","pmd":26.27}
{"X":6742,"KEGG":"R10200","RHEA_ID":34270,"DIRECTION":"BI","MASTER_ID":34267,"compounds":"acetyl-CoA + fumigaclavine B <=> CoA + fumigaclavine A","pmd":42.011}
{"X":6743,"KEGG":"R10200","RHEA_ID":34270,"DIRECTION":"BI","MASTER_ID":34267,"compounds":"acetyl-CoA + fumigaclavine B <=> CoA + fumigaclavine A","pmd":42.01}
{"X":6744,"KEGG":"R10201","RHEA_ID":34266,"DIRECTION":"BI","MASTER_ID":34263,"compounds":"dimethylallyl diphosphate + fumigaclavine A <=> diphosphate + fumigaclavine C","pmd":120.225}
{"X":6745,"KEGG":"R10201","RHEA_ID":34266,"DIRECTION":"BI","MASTER_ID":34263,"compounds":"dimethylallyl diphosphate + fumigaclavine A <=> diphosphate + fumigaclavine C","pmd":68.063}
{"X":6746,"KEGG":"R10204","RHEA_ID":34710,"DIRECTION":"BI","MASTER_ID":34707,"compounds":"AH2 + alpha-D-ribose 1-methylphosphonate 5-phosphate + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + A + alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H(+) + L-methionine + methane","pmd":106.162}
{"X":6747,"KEGG":"R10204","RHEA_ID":34710,"DIRECTION":"BI","MASTER_ID":34707,"compounds":"AH2 + alpha-D-ribose 1-methylphosphonate 5-phosphate + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + A + alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H(+) + L-methionine + methane","pmd":16.031}
{"X":6748,"KEGG":"R10206","RHEA_ID":29310,"DIRECTION":"BI","MASTER_ID":29307,"compounds":"FMNH2 + methanesulfonate + O2 <=> FMN + formaldehyde + 2 H(+) + H2O + sulfite","pmd":2.016}
{"X":6749,"KEGG":"R10208","RHEA_ID":13100,"DIRECTION":"BI","MASTER_ID":13097,"compounds":"a (3R)-hydroxyacyl-[ACP] <=> a (2E)-enoyl-[ACP] + H2O"}
{"X":6750,"KEGG":"R10209","RHEA_ID":24107,"DIRECTION":"BI","MASTER_ID":24104,"compounds":"7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA <=> 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine","pmd":28.031}
{"X":6751,"KEGG":"R10221","RHEA_ID":33026,"DIRECTION":"BI","MASTER_ID":33023,"compounds":"6-phospho-D-gluconate + NAD(+) <=> CO2 + D-ribulose 5-phosphate + NADH","pmd":434.098}
{"X":6752,"KEGG":"R10221","RHEA_ID":33026,"DIRECTION":"BI","MASTER_ID":33023,"compounds":"6-phospho-D-gluconate + NAD(+) <=> CO2 + D-ribulose 5-phosphate + NADH","pmd":46.005}
{"X":6753,"KEGG":"R10223","RHEA_ID":43171,"DIRECTION":"BI","MASTER_ID":43168,"metacyc":"RXN-13997","compounds":"adenosine(34) in tRNA + H(+) + H2O <=> inosine(34) in tRNA + NH4(+)"}
{"X":6754,"KEGG":"R10224","RHEA_ID":35194,"DIRECTION":"BI","MASTER_ID":35191,"compounds":"noranthrone + O2 <=> H2O + norsolorinic acid","pmd":13.979}
{"X":6755,"KEGG":"R10225","RHEA_ID":34422,"DIRECTION":"BI","MASTER_ID":34419,"compounds":"(+)-lariciresinol + NADP(+) <=> (+)-pinoresinol + H(+) + NADPH","pmd":2.016}
{"X":6756,"KEGG":"R10225","RHEA_ID":34422,"DIRECTION":"BI","MASTER_ID":34419,"compounds":"(+)-lariciresinol + NADP(+) <=> (+)-pinoresinol + H(+) + NADPH","pmd":385.942}
{"X":6757,"KEGG":"R10226","RHEA_ID":34426,"DIRECTION":"BI","MASTER_ID":34423,"compounds":"(-)-secoisolariciresinol + NADP(+) <=> (+)-lariciresinol + H(+) + NADPH","pmd":2.016}
{"X":6758,"KEGG":"R10226","RHEA_ID":34426,"DIRECTION":"BI","MASTER_ID":34423,"compounds":"(-)-secoisolariciresinol + NADP(+) <=> (+)-lariciresinol + H(+) + NADPH","pmd":383.926}
{"X":6759,"KEGG":"R10227","RHEA_ID":34430,"DIRECTION":"BI","MASTER_ID":34427,"compounds":"(-)-lariciresinol + NADP(+) <=> (-)-pinoresinol + H(+) + NADPH","pmd":385.942}
{"X":6760,"KEGG":"R10227","RHEA_ID":34430,"DIRECTION":"BI","MASTER_ID":34427,"compounds":"(-)-lariciresinol + NADP(+) <=> (-)-pinoresinol + H(+) + NADPH","pmd":2.016}
{"X":6761,"KEGG":"R10228","RHEA_ID":34434,"DIRECTION":"BI","MASTER_ID":34431,"compounds":"(+)-secoisolariciresinol + NADP(+) <=> (-)-lariciresinol + H(+) + NADPH","pmd":383.926}
{"X":6762,"KEGG":"R10228","RHEA_ID":34434,"DIRECTION":"BI","MASTER_ID":34431,"compounds":"(+)-secoisolariciresinol + NADP(+) <=> (-)-lariciresinol + H(+) + NADPH","pmd":2.016}
{"X":6763,"KEGG":"R10229","RHEA_ID":34062,"DIRECTION":"BI","MASTER_ID":34059,"compounds":"agroclavine + NADP(+) <=> didehydroagroclavine + H(+) + NADPH","pmd":506.944}
{"X":6764,"KEGG":"R10230","RHEA_ID":19972,"DIRECTION":"BI","MASTER_ID":19969,"compounds":"hydroxylamine + O2 <=> H(+) + H2O + nitrite"}
{"X":6765,"KEGG":"R10231","RHEA_ID":50971,"DIRECTION":"BI","MASTER_ID":50968,"metacyc":"RXN-13996","compounds":"adenosine(37) in tRNA(Ala) + H(+) + H2O <=> inosine(37) in tRNA(Ala) + NH4(+)"}
{"X":6766,"KEGG":"R10233","RHEA_ID":34806,"DIRECTION":"BI","MASTER_ID":34803,"metacyc":"RXN-13958","compounds":"2 4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA <=> bisdemethoxycurcumin + 2 CO2 + 3 CoA","pmd":86}
{"X":6767,"KEGG":"R10233","RHEA_ID":34806,"DIRECTION":"BI","MASTER_ID":34803,"metacyc":"RXN-13958","compounds":"2 4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA <=> bisdemethoxycurcumin + 2 CO2 + 3 CoA","pmd":146.037}
{"X":6768,"KEGG":"R10234","RHEA_ID":34486,"DIRECTION":"BI","MASTER_ID":34483,"compounds":"4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA <=> 4-hydroxybenzalacetone + 2 CO2 + 2 CoA","pmd":86}
{"X":6769,"KEGG":"R10234","RHEA_ID":34486,"DIRECTION":"BI","MASTER_ID":34483,"compounds":"4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA <=> 4-hydroxybenzalacetone + 2 CO2 + 2 CoA","pmd":146.037}
{"X":6770,"KEGG":"R10235","RHEA_ID":35214,"DIRECTION":"BI","MASTER_ID":35211,"compounds":"dIDP + H2O <=> dIMP + H(+) + phosphate","pmd":79.966}
{"X":6771,"KEGG":"R10236","RHEA_ID":35402,"DIRECTION":"BI","MASTER_ID":35399,"compounds":"1-O-(trans-4-coumaroyl)-beta-D-glucose + cyanidin 3-O-(6-O-glucosyl-2-O-xylosylgalactoside) betaine <=> beta-D-glucose + cyanidin 3-O-[6-O-(6-O-4-hydroxycinnamoyl-beta-D-glucosyl)-2-O-beta-D-xylosyl-beta-D-galactoside] + H(+)","pmd":146.037}
{"X":6772,"KEGG":"R10237","RHEA_ID":35414,"DIRECTION":"BI","MASTER_ID":35411,"metacyc":"RXN-13959","compounds":"(E)-4-coumaroyl-CoA + an anthocyanidin 3-O-beta-D-glucoside <=> an anthocyanidin 3-O-[6-O-(4-hydroxycinnamoyl)-beta-D--glucoside] + CoA + H(+)","pmd":146.037}
{"X":6773,"KEGG":"R10238","RHEA_ID":34842,"DIRECTION":"BI","MASTER_ID":34839,"compounds":"4 H(+) + 5 malonyl-CoA <=> 5,7-dihydroxy-2-methyl-4H-chromen-4-one + 5 CO2 + 5 CoA + H2O","pmd":86}
{"X":6774,"KEGG":"R10239","RHEA_ID":35182,"DIRECTION":"BI","MASTER_ID":35179,"compounds":"6 H(+) + hexanoyl-[ACP] + 7 malonyl-CoA <=> 7 CO2 + 7 CoA + 2 H2O + holo-[ACP] + noranthrone","pmd":86}
{"X":6775,"KEGG":"R10240","RHEA_ID":35634,"DIRECTION":"BI","MASTER_ID":35631,"compounds":"cyanidin + UDP-alpha-D-galactose <=> cyanidin 3-O-beta-D-galactoside + H(+) + UDP","pmd":116.947}
{"X":6776,"KEGG":"R10241","RHEA_ID":34462,"DIRECTION":"BI","MASTER_ID":34459,"compounds":"8-hydroxycopalyl diphosphate + H2O <=> diphosphate + sclareol","pmd":159.933}
{"X":6777,"KEGG":"R10245","RHEA_ID":33350,"DIRECTION":"BI","MASTER_ID":33347,"compounds":"2-iminoacetate + H2O <=> glyoxylate + NH4(+)"}
{"X":6778,"KEGG":"R10246","RHEA_ID":26364,"DIRECTION":"BI","MASTER_ID":26361,"compounds":"L-tyrosine + NADPH + S-adenosyl-L-methionine <=> 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP(+)","pmd":32.023}
{"X":6779,"KEGG":"R10246","RHEA_ID":26364,"DIRECTION":"BI","MASTER_ID":26361,"compounds":"L-tyrosine + NADPH + S-adenosyl-L-methionine <=> 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP(+)","pmd":147.035}
{"X":6780,"KEGG":"R10247","RHEA_ID":26300,"DIRECTION":"BI","MASTER_ID":26297,"compounds":"1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH <=> 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O","pmd":52.972}
{"X":6781,"KEGG":"R10248","RHEA_ID":24693,"DIRECTION":"BI","MASTER_ID":24690,"compounds":"acetate + eugenol + NADP(+) <=> coniferyl acetate + NADPH","pmd":58.006}
{"X":6782,"KEGG":"R10248","RHEA_ID":24693,"DIRECTION":"BI","MASTER_ID":24690,"compounds":"acetate + eugenol + NADP(+) <=> coniferyl acetate + NADPH","pmd":581.007}
{"X":6783,"KEGG":"R10252","RHEA_ID":36250,"DIRECTION":"BI","MASTER_ID":36247,"compounds":"S-adenosyl-L-methionine + trans-anol <=> H(+) + S-adenosyl-L-homocysteine + trans-anethole","pmd":14.016}
{"X":6784,"KEGG":"R10255","RHEA_ID":35442,"DIRECTION":"BI","MASTER_ID":35439,"compounds":"CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol + L-serine <=> archaetidylserine + CMP + H(+)","pmd":218.009}
{"X":6785,"KEGG":"R10256","RHEA_ID":35446,"DIRECTION":"BI","MASTER_ID":35443,"compounds":"an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-xylose <=> an anthocyanidin 3-O-beta-D-sambubioside + 2 H(+) + UDP","pmd":132.042}
{"X":6786,"KEGG":"R10257","RHEA_ID":35438,"DIRECTION":"BI","MASTER_ID":35435,"compounds":"cyanidin 3-O-beta-D-galactoside + UDP-alpha-D-xylose <=> cyanidin 3-O-[beta-D-xylosyl-(1->2)-beta-D-galactoside] + H(+) + UDP","pmd":45.106}
{"X":6787,"KEGG":"R10258","RHEA_ID":61131,"DIRECTION":"BI","MASTER_ID":61128,"compounds":"O2 + quercetin + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + myricetin + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":6788,"KEGG":"R10259","RHEA_ID":35434,"DIRECTION":"BI","MASTER_ID":35431,"compounds":"1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside <=> 4-hydroxy-3-methoxybenzoate + cyanidin 3,7-di-O-beta-D-glucoside","pmd":162.053}
{"X":6789,"KEGG":"R10261","RHEA_ID":35430,"DIRECTION":"BI","MASTER_ID":35427,"compounds":"1-O-(trans-sinapoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside <=> cyanidin 3,5-di-O-beta-D-glucoside + trans-sinapate","pmd":162.053}
{"X":6790,"KEGG":"R10262","RHEA_ID":35426,"DIRECTION":"BI","MASTER_ID":35423,"compounds":"an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose <=> an anthocyanidin 3,5-di-O-beta-D-glucoside + 2 H(+) + UDP","pmd":162.053}
{"X":6791,"KEGG":"R10263","RHEA_ID":35422,"DIRECTION":"BI","MASTER_ID":35419,"compounds":"an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose <=> an anthocyanidin 3-O-sophoroside + 2 H(+) + UDP","pmd":162.053}
{"X":6792,"KEGG":"R10264","RHEA_ID":35638,"DIRECTION":"BI","MASTER_ID":35635,"compounds":"an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + UDP-alpha-D-glucose <=> an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] 5-O-beta-D-glucoside + H(+) + UDP","pmd":162.053}
{"X":6793,"KEGG":"R10265","RHEA_ID":35418,"DIRECTION":"BI","MASTER_ID":35415,"compounds":"an anthocyanidin 3-O-beta-D-sambubioside + UDP-alpha-D-glucose <=> an anthocyanidin 5-O-beta-D-glucoside 3-O-beta-D-sambubioside + H(+) + UDP","pmd":162.053}
{"X":6794,"KEGG":"R10266","RHEA_ID":30826,"DIRECTION":"BI","MASTER_ID":30823,"compounds":"UDP-N-acetyl-alpha-D-glucosamine <=> H2O + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose","pmd":18.011}
{"X":6795,"KEGG":"R10267","RHEA_ID":32226,"DIRECTION":"BI","MASTER_ID":32223,"compounds":"(6S)-NADHX + ADP <=> AMP + H(+) + NADH + phosphate","pmd":18.01}
{"X":6796,"KEGG":"R10267","RHEA_ID":32226,"DIRECTION":"BI","MASTER_ID":32223,"compounds":"(6S)-NADHX + ADP <=> AMP + H(+) + NADH + phosphate","pmd":79.966}
{"X":6797,"KEGG":"R10268","RHEA_ID":32238,"DIRECTION":"BI","MASTER_ID":32235,"compounds":"(6S)-NADPHX + ADP <=> AMP + H(+) + NADPH + phosphate","pmd":18.011}
{"X":6798,"KEGG":"R10268","RHEA_ID":32238,"DIRECTION":"BI","MASTER_ID":32235,"compounds":"(6S)-NADPHX + ADP <=> AMP + H(+) + NADPH + phosphate","pmd":79.966}
{"X":6799,"KEGG":"R10269","RHEA_ID":34258,"DIRECTION":"BI","MASTER_ID":34255,"metacyc":"RXN-13335","compounds":"sporulenol <=> H2O + tetraprenyl-beta-curcumene","pmd":18.011}
{"X":6800,"KEGG":"R10270","RHEA_ID":34094,"DIRECTION":"BI","MASTER_ID":34091,"metacyc":"RXN-13609","compounds":"(5R)-5-phosphooxy-L-lysine + H2O <=> (S)-2-amino-6-oxohexanoate + NH4(+) + phosphate","pmd":96.993}
{"X":6801,"KEGG":"R10271","RHEA_ID":34698,"DIRECTION":"BI","MASTER_ID":34695,"compounds":"(2E,6E)-farnesyl diphosphate <=> Delta(6)-protoilludene + diphosphate","pmd":177.943}
{"X":6802,"KEGG":"R10272","RHEA_ID":34702,"DIRECTION":"BI","MASTER_ID":34699,"compounds":"(2E,6E)-farnesyl diphosphate <=> (-)-alpha-isocomene + diphosphate","pmd":177.943}
{"X":6803,"KEGG":"R10273","RHEA_ID":34706,"DIRECTION":"BI","MASTER_ID":34703,"compounds":"(2E,6E)-farnesyl diphosphate <=> (E)-2-epi-beta-caryophyllene + diphosphate","pmd":177.943}
{"X":6804,"KEGG":"R10274","RHEA_ID":34506,"DIRECTION":"BI","MASTER_ID":34503,"compounds":"(2E,6E)-farnesyl diphosphate + H2O <=> (+)-epi-alpha-bisabolol + diphosphate","pmd":159.933}
{"X":6805,"KEGG":"R10275","RHEA_ID":34470,"DIRECTION":"BI","MASTER_ID":34467,"compounds":"(2E,6E)-farnesyl diphosphate <=> diphosphate + valerena-4,7(11)-diene","pmd":177.943}
{"X":6806,"KEGG":"R10276","RHEA_ID":34466,"DIRECTION":"BI","MASTER_ID":34463,"compounds":"8-hydroxycopalyl diphosphate <=> cis-abienol + diphosphate","pmd":177.943}
{"X":6807,"KEGG":"R10277","RHEA_ID":34306,"DIRECTION":"BI","MASTER_ID":34303,"metacyc":"RXN-13654","compounds":"L-lysine <=> L-pipecolate + NH4(+)","pmd":17.026}
{"X":6808,"KEGG":"R10278","RHEA_ID":34126,"DIRECTION":"BI","MASTER_ID":34123,"compounds":"3,5,7-trioxododecanoyl-CoA <=> CoA + H(+) + olivetolate","pmd":224.105}
{"X":6809,"KEGG":"R10279","RHEA_ID":34454,"DIRECTION":"BI","MASTER_ID":34451,"metacyc":"RXN-13776","compounds":"dTDP-6-deoxy-beta-L-talose <=> dTDP-beta-L-rhamnose","pmd":0}
{"X":6810,"KEGG":"R10280","RHEA_ID":32218,"DIRECTION":"BI","MASTER_ID":32215,"compounds":"(6R)-NADHX <=> (6S)-NADHX","pmd":0}
{"X":6811,"KEGG":"R10281","RHEA_ID":32230,"DIRECTION":"BI","MASTER_ID":32227,"compounds":"(6R)-NADPHX <=> (6S)-NADPHX","pmd":0}
{"X":6812,"KEGG":"R10282","RHEA_ID":34458,"DIRECTION":"BI","MASTER_ID":34455,"metacyc":"RXN-13641","compounds":"all-trans-beta-carotene <=> 9-cis-beta-carotene","pmd":0}
{"X":6813,"KEGG":"R10283","RHEA_ID":35642,"DIRECTION":"BI","MASTER_ID":35639,"metacyc":"RXN-13990","compounds":"(4S)-4-hydroxy-2-oxoglutarate <=> glyoxylate + pyruvate"}
{"X":6814,"KEGG":"R10284","RHEA_ID":35750,"DIRECTION":"BI","MASTER_ID":35747,"compounds":"(2E,6E)-farnesyl diphosphate <=> 7-epizingiberene + diphosphate","pmd":177.943}
{"X":6815,"KEGG":"R10285","RHEA_ID":35098,"DIRECTION":"BI","MASTER_ID":35095,"compounds":"choline <=> acetaldehyde + trimethylamine"}
{"X":6816,"KEGG":"R10286","RHEA_ID":34398,"DIRECTION":"BI","MASTER_ID":34395,"compounds":"L-phenylalanine <=> L-beta-phenylalanine","pmd":0}
{"X":6817,"KEGG":"R10287","RHEA_ID":34530,"DIRECTION":"BI","MASTER_ID":34527,"compounds":"L-phenylalanine <=> (S)-3-amino-3-phenylpropanoate","pmd":0}
{"X":6818,"KEGG":"R10288","RHEA_ID":32234,"DIRECTION":"BI","MASTER_ID":32231,"compounds":"(6S)-NADPHX + ATP <=> ADP + H(+) + NADPH + phosphate","pmd":18.011}
{"X":6819,"KEGG":"R10288","RHEA_ID":32234,"DIRECTION":"BI","MASTER_ID":32231,"compounds":"(6S)-NADPHX + ATP <=> ADP + H(+) + NADPH + phosphate","pmd":79.966}
{"X":6820,"KEGG":"R10303","RHEA_ID":28762,"DIRECTION":"BI","MASTER_ID":28759,"compounds":"beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-1-diphospho-di-trans,octa-cis-undecaprenol + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose <=> alpha-D-FucNAc4-(1->4)-beta-D-ManNAcA-(1->4)-D-GlcNAc-undecaprenyl diphosphate + dTDP + H(+)","pmd":187.084}
{"X":6821,"KEGG":"R10304","RHEA_ID":34510,"DIRECTION":"BI","MASTER_ID":34507,"compounds":"2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H2O + phosphoenolpyruvate <=> N,N-diacetyllegionaminate + phosphate","pmd":88.016}
{"X":6822,"KEGG":"R10304","RHEA_ID":34510,"DIRECTION":"BI","MASTER_ID":34507,"compounds":"2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H2O + phosphoenolpyruvate <=> N,N-diacetyllegionaminate + phosphate","pmd":166.155}
{"X":6823,"KEGG":"R10305","RHEA_ID":32746,"DIRECTION":"BI","MASTER_ID":32743,"metacyc":"RXN-721","compounds":"L-homocysteine + O-acetyl-L-serine <=> acetate + H(+) + L,L-cystathionine","pmd":75.014}
{"X":6824,"KEGG":"R10305","RHEA_ID":32746,"DIRECTION":"BI","MASTER_ID":32743,"metacyc":"RXN-721","compounds":"L-homocysteine + O-acetyl-L-serine <=> acetate + H(+) + L,L-cystathionine","pmd":87.032}
{"X":6825,"KEGG":"R10306","RHEA_ID":36418,"DIRECTION":"BI","MASTER_ID":36415,"compounds":"2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine <=> diphthine-[translation elongation factor 2] + 3 H(+) + 3 S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6826,"KEGG":"R10307","RHEA_ID":35770,"DIRECTION":"BI","MASTER_ID":35767,"compounds":"dihydrosterigmatocystin + S-adenosyl-L-methionine <=> 8-O-methyldihydrosterigmatocystin + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6827,"KEGG":"R10308","RHEA_ID":34350,"DIRECTION":"BI","MASTER_ID":34347,"metacyc":"RXN-11968","compounds":"geraniol + NAD(+) <=> geranial + H(+) + NADH","pmd":2.016}
{"X":6828,"KEGG":"R10308","RHEA_ID":34350,"DIRECTION":"BI","MASTER_ID":34347,"metacyc":"RXN-11968","compounds":"geraniol + NAD(+) <=> geranial + H(+) + NADH","pmd":511.997}
{"X":6829,"KEGG":"R10309","RHEA_ID":35450,"DIRECTION":"BI","MASTER_ID":35447,"metacyc":"RXN-9480","compounds":"(1'S)-averantin + NADP(+) <=> H(+) + NADPH + norsolorinic acid","pmd":373.978}
{"X":6830,"KEGG":"R10309","RHEA_ID":35450,"DIRECTION":"BI","MASTER_ID":35447,"metacyc":"RXN-9480","compounds":"(1'S)-averantin + NADP(+) <=> H(+) + NADPH + norsolorinic acid","pmd":2.016}
{"X":6831,"KEGG":"R10310","RHEA_ID":35478,"DIRECTION":"BI","MASTER_ID":35475,"compounds":"(1'S,5'S)-5'-hydroxyaverantin + NAD(+) <=> (S)-5'-oxoaverantin + H(+) + NADH","pmd":278.017}
{"X":6832,"KEGG":"R10310","RHEA_ID":35478,"DIRECTION":"BI","MASTER_ID":35475,"compounds":"(1'S,5'S)-5'-hydroxyaverantin + NAD(+) <=> (S)-5'-oxoaverantin + H(+) + NADH","pmd":2.016}
{"X":6833,"KEGG":"R10311","RHEA_ID":35482,"DIRECTION":"BI","MASTER_ID":35479,"compounds":"(1'S,5'R)-5'-hydroxyaverantin + NAD(+) <=> (S)-5'-oxoaverantin + 2 H(+) + NADH","pmd":278.017}
{"X":6834,"KEGG":"R10311","RHEA_ID":35482,"DIRECTION":"BI","MASTER_ID":35479,"compounds":"(1'S,5'R)-5'-hydroxyaverantin + NAD(+) <=> (S)-5'-oxoaverantin + 2 H(+) + NADH","pmd":2.016}
{"X":6835,"KEGG":"R10312","RHEA_ID":35834,"DIRECTION":"BI","MASTER_ID":35831,"compounds":"2-oxoglutarate + kanamycin B + O2 <=> 2'-dehydrokanamycin A + CO2 + NH4(+) + succinate","pmd":27.995}
{"X":6836,"KEGG":"R10312","RHEA_ID":35834,"DIRECTION":"BI","MASTER_ID":35831,"compounds":"2-oxoglutarate + kanamycin B + O2 <=> 2'-dehydrokanamycin A + CO2 + NH4(+) + succinate","pmd":1.032}
{"X":6837,"KEGG":"R10313","RHEA_ID":35506,"DIRECTION":"BI","MASTER_ID":35503,"compounds":"11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> 30-hydroxy-11-oxo-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":6838,"KEGG":"R10314","RHEA_ID":35510,"DIRECTION":"BI","MASTER_ID":35507,"compounds":"30-hydroxy-11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> glycyrrhetaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]","pmd":2.016}
{"X":6839,"KEGG":"R10315","RHEA_ID":35514,"DIRECTION":"BI","MASTER_ID":35511,"compounds":"glycyrrhetaldehyde + O2 + reduced [NADPH--hemoprotein reductase] <=> glycyrrhetinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":6840,"KEGG":"R10316","RHEA_ID":35502,"DIRECTION":"BI","MASTER_ID":35499,"compounds":"11-oxo-beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> glycyrrhetinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]","pmd":29.974}
{"X":6841,"KEGG":"R10317","RHEA_ID":35574,"DIRECTION":"BI","MASTER_ID":35571,"compounds":"(1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase] <=> (1'S,5'S)-5'-hydroxyaverantin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":6842,"KEGG":"R10318","RHEA_ID":35578,"DIRECTION":"BI","MASTER_ID":35575,"compounds":"(1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase] <=> (1'S,5'R)-5'-hydroxyaverantin + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":6843,"KEGG":"R10319","RHEA_ID":35762,"DIRECTION":"BI","MASTER_ID":35759,"compounds":"8-O-methylsterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> aflatoxin B1 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase]","pmd":26.016}
{"X":6844,"KEGG":"R10320","RHEA_ID":35766,"DIRECTION":"BI","MASTER_ID":35763,"compounds":"8-O-methyldihydrosterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> aflatoxin B2 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase]","pmd":26.016}
{"X":6845,"KEGG":"R10321","RHEA_ID":35958,"DIRECTION":"BI","MASTER_ID":35955,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin B <=> 6-hydroxytryprostatin B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":6846,"KEGG":"R10322","RHEA_ID":35558,"DIRECTION":"BI","MASTER_ID":35555,"compounds":"cyclo(L-leucyl-L-leucyl) + 4 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] + pulcherriminic acid","pmd":29.974}
{"X":6847,"KEGG":"R10323","RHEA_ID":35550,"DIRECTION":"BI","MASTER_ID":35547,"compounds":"cyclo(L-tyrosyl-L-tyrosyl) + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 H2O + mycoclysin + 2 oxidized [2Fe-2S]-[ferredoxin]","pmd":2.016}
{"X":6848,"KEGG":"R10324","RHEA_ID":36050,"DIRECTION":"BI","MASTER_ID":36047,"compounds":"A + D-glyceraldehyde + H2O <=> (R)-glycerate + AH2 + H(+)"}
{"X":6849,"KEGG":"R10326","RHEA_ID":36038,"DIRECTION":"BI","MASTER_ID":36035,"compounds":"2,3-bis-(O-phytanyl)-sn-glycerol 1-phosphate + 8 NADP(+) <=> 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADPH","pmd":27.569}
{"X":6850,"KEGG":"R10326","RHEA_ID":36038,"DIRECTION":"BI","MASTER_ID":36035,"compounds":"2,3-bis-(O-phytanyl)-sn-glycerol 1-phosphate + 8 NADP(+) <=> 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADPH","pmd":12.451}
{"X":6851,"KEGG":"R10326","RHEA_ID":36042,"DIRECTION":"BI","MASTER_ID":36039,"compounds":"2,3-bis-(O-phytanyl)-sn-glycerol 1-phosphate + 8 NAD(+) <=> 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADH","pmd":27.569}
{"X":6852,"KEGG":"R10326","RHEA_ID":36042,"DIRECTION":"BI","MASTER_ID":36039,"compounds":"2,3-bis-(O-phytanyl)-sn-glycerol 1-phosphate + 8 NAD(+) <=> 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADH","pmd":12.451}
{"X":6853,"KEGG":"R10327","RHEA_ID":35538,"DIRECTION":"BI","MASTER_ID":35535,"compounds":"cyclo(L-phenylalanyl-L-leucyl) + O2 <=> cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + H2O2","pmd":2.016}
{"X":6854,"KEGG":"R10328","RHEA_ID":35542,"DIRECTION":"BI","MASTER_ID":35539,"compounds":"cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + O2 <=> albonoursin + H2O2","pmd":2.016}
{"X":6855,"KEGG":"R10329","RHEA_ID":35534,"DIRECTION":"BI","MASTER_ID":35531,"compounds":"cyclo(L-phenylalanyl-L-leucyl) + 2 O2 <=> albonoursin + 2 H2O2","pmd":4.031}
{"X":6856,"KEGG":"R10330","RHEA_ID":36062,"DIRECTION":"BI","MASTER_ID":36059,"compounds":"A + dihydrourocanate <=> AH2 + urocanate","pmd":2.016}
{"X":6857,"KEGG":"R10331","RHEA_ID":36162,"DIRECTION":"BI","MASTER_ID":36159,"compounds":"2,3-bis-(O-phytanyl)-sn-glycerol 1-phosphate + 16 oxidized [2Fe-2S]-[ferredoxin] <=> 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate + 16 H(+) + 16 reduced [2Fe-2S]-[ferredoxin]","pmd":16.125}
{"X":6858,"KEGG":"R10332","RHEA_ID":35826,"DIRECTION":"BI","MASTER_ID":35823,"metacyc":"RXN-10029","compounds":"5,6,7,8-tetrahydromethanopterin + NAD(+) <=> 7,8-dihydromethanopterin + H(+) + NADH","pmd":2.016}
{"X":6859,"KEGG":"R10332","RHEA_ID":35826,"DIRECTION":"BI","MASTER_ID":35823,"metacyc":"RXN-10029","compounds":"5,6,7,8-tetrahydromethanopterin + NAD(+) <=> 7,8-dihydromethanopterin + H(+) + NADH","pmd":110.13}
{"X":6860,"KEGG":"R10333","RHEA_ID":35470,"DIRECTION":"BI","MASTER_ID":35467,"compounds":"(6S)-5,6,7,8-tetrahydrofolate + S,S-dimethyl-beta-propiothetin <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-(methylsulfanyl)propanoate + H(+)","pmd":14.016}
{"X":6861,"KEGG":"R10334","RHEA_ID":50943,"DIRECTION":"BI","MASTER_ID":50940,"metacyc":"RXN-14335","compounds":"L-leucyl-tRNA(Leu) + L-phenylalanyl-tRNA(Phe) <=> cyclo(L-phenylalanyl-L-leucyl) + H(+) + tRNA(Leu) + tRNA(Phe)"}
{"X":6862,"KEGG":"R10335","RHEA_ID":46451,"DIRECTION":"BI","MASTER_ID":46448,"compounds":"2 L-tyrosyl-tRNA(Tyr) <=> cyclo(L-tyrosyl-L-tyrosyl) + 2 tRNA(Tyr)"}
{"X":6863,"KEGG":"R10336","RHEA_ID":46455,"DIRECTION":"BI","MASTER_ID":46452,"compounds":"2 L-leucyl-tRNA(Leu) <=> cyclo(L-leucyl-L-leucyl) + 2 H(+) + 2 tRNA(Leu)"}
{"X":6864,"KEGG":"R10337","RHEA_ID":48559,"DIRECTION":"BI","MASTER_ID":48556,"compounds":"4-hydroxybenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) <=> 4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate","pmd":84.885}
{"X":6865,"KEGG":"R10337","RHEA_ID":48559,"DIRECTION":"BI","MASTER_ID":48556,"compounds":"4-hydroxybenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) <=> 4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate","pmd":168.019}
{"X":6866,"KEGG":"R10338","RHEA_ID":36490,"DIRECTION":"BI","MASTER_ID":36487,"compounds":"agmatine + S-adenosyl 3-(methylsulfanyl)propylamine <=> H(+) + N(1)-aminopropylagmatine + S-methyl-5'-thioadenosine","pmd":57.058}
{"X":6867,"KEGG":"R10338","RHEA_ID":36490,"DIRECTION":"BI","MASTER_ID":36487,"compounds":"agmatine + S-adenosyl 3-(methylsulfanyl)propylamine <=> H(+) + N(1)-aminopropylagmatine + S-methyl-5'-thioadenosine","pmd":58.066}
{"X":6868,"KEGG":"R10339","RHEA_ID":35954,"DIRECTION":"BI","MASTER_ID":35951,"compounds":"(7,8-dihydropterin-6-yl)methyl diphosphate + 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate <=> diphosphate + N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate","pmd":177.065}
{"X":6869,"KEGG":"R10339","RHEA_ID":35954,"DIRECTION":"BI","MASTER_ID":35951,"compounds":"(7,8-dihydropterin-6-yl)methyl diphosphate + 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate <=> diphosphate + N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate","pmd":127.123}
{"X":6870,"KEGG":"R10340","RHEA_ID":35942,"DIRECTION":"BI","MASTER_ID":35939,"compounds":"brevianamide F + dimethylallyl diphosphate <=> diphosphate + tryprostatin B","pmd":105.189}
{"X":6871,"KEGG":"R10340","RHEA_ID":35942,"DIRECTION":"BI","MASTER_ID":35939,"compounds":"brevianamide F + dimethylallyl diphosphate <=> diphosphate + tryprostatin B","pmd":68.063}
{"X":6872,"KEGG":"R10341","RHEA_ID":35982,"DIRECTION":"BI","MASTER_ID":35979,"compounds":"dimethylallyl diphosphate + verruculogen <=> diphosphate + fumitremorgin A","pmd":333.289}
{"X":6873,"KEGG":"R10341","RHEA_ID":35982,"DIRECTION":"BI","MASTER_ID":35979,"compounds":"dimethylallyl diphosphate + verruculogen <=> diphosphate + fumitremorgin A","pmd":68.063}
{"X":6874,"KEGG":"R10342","RHEA_ID":35658,"DIRECTION":"BI","MASTER_ID":35655,"metacyc":"RXN-14338","compounds":"2 ATP <=> 3',3'-c-di-AMP + 2 diphosphate","pmd":151.109}
{"X":6875,"KEGG":"R10343","RHEA_ID":35714,"DIRECTION":"BI","MASTER_ID":35711,"metacyc":"RXN-8807","compounds":"acetate + succinyl-CoA <=> acetyl-CoA + succinate","pmd":58.005}
{"X":6876,"KEGG":"R10344","RHEA_ID":35802,"DIRECTION":"BI","MASTER_ID":35799,"compounds":"7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O <=> 7,8-dihydroneopterin 3'-phosphate + H(+)","pmd":18.011}
{"X":6877,"KEGG":"R10345","RHEA_ID":35806,"DIRECTION":"BI","MASTER_ID":35803,"compounds":"7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O <=> 7,8-dihydroneopterin 2'-phosphate + H(+)","pmd":18.011}
{"X":6878,"KEGG":"R10346","RHEA_ID":36054,"DIRECTION":"BI","MASTER_ID":36051,"compounds":"beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose + H2O <=> 2 beta-L-arabinofuranose","pmd":132.042}
{"X":6879,"KEGG":"R10347","RHEA_ID":35830,"DIRECTION":"BI","MASTER_ID":35827,"compounds":"H2O + N(1)-aminopropylagmatine <=> spermidine + urea","pmd":42.022}
{"X":6880,"KEGG":"R10348","RHEA_ID":25863,"DIRECTION":"BI","MASTER_ID":25860,"compounds":"GTP + H2O <=> 7,8-dihydroneopterin 2',3'-cyclic phosphate + diphosphate + formate + H(+)","pmd":205.938}
{"X":6881,"KEGG":"R10385","RHEA_ID":45199,"DIRECTION":"BI","MASTER_ID":45196,"compounds":"5,6,7,8-tetrahydrosarcinapterin + [methyl-Co(III) corrinoid Fe-S protein] <=> 5-methyltetrahydrosarcinapterin + [Co(I) corrinoid Fe-S protein] + H(+)","pmd":14.016}
{"X":6882,"KEGG":"R10388","RHEA_ID":20979,"DIRECTION":"BI","MASTER_ID":20976,"compounds":"a primary nitroalkane + H2O + O2 <=> an aldehyde + H(+) + H2O2 + nitrite"}
{"X":6883,"KEGG":"R10389","RHEA_ID":26493,"DIRECTION":"BI","MASTER_ID":26490,"compounds":"a secondary nitroalkane + H2O + O2 <=> a ketone + H(+) + H2O2 + nitrite"}
{"X":6884,"KEGG":"R10390","RHEA_ID":35594,"DIRECTION":"BI","MASTER_ID":35591,"compounds":"H2 + n sulfur <=> H(+) + hydrogen sulfide + (n-1) sulfur"}
{"X":6885,"KEGG":"R10398","RHEA_ID":35722,"DIRECTION":"BI","MASTER_ID":35719,"compounds":"(3S)-versiconol acetate + H2O <=> (S)-versiconol + acetate + H(+)","pmd":42.011}
{"X":6886,"KEGG":"R10399","RHEA_ID":35698,"DIRECTION":"BI","MASTER_ID":35695,"compounds":"(3S)-versiconol acetate + NADP(+) <=> (2S,3S)-versiconal hemiacetal acetate + H(+) + NADPH","pmd":344.004}
{"X":6887,"KEGG":"R10399","RHEA_ID":35698,"DIRECTION":"BI","MASTER_ID":35695,"compounds":"(3S)-versiconol acetate + NADP(+) <=> (2S,3S)-versiconal hemiacetal acetate + H(+) + NADPH","pmd":2.016}
{"X":6888,"KEGG":"R10400","RHEA_ID":35702,"DIRECTION":"BI","MASTER_ID":35699,"compounds":"(S)-versiconol + NADP(+) <=> (2S-3S)-versiconal hemiacetal + H(+) + NADPH","pmd":386.014}
{"X":6889,"KEGG":"R10400","RHEA_ID":35702,"DIRECTION":"BI","MASTER_ID":35699,"compounds":"(S)-versiconol + NADP(+) <=> (2S-3S)-versiconal hemiacetal + H(+) + NADPH","pmd":2.016}
{"X":6890,"KEGG":"R10401","RHEA_ID":35718,"DIRECTION":"BI","MASTER_ID":35715,"compounds":"(2S,3S)-versiconal hemiacetal acetate + H2O <=> (2S-3S)-versiconal hemiacetal + acetate + H(+)","pmd":42.011}
{"X":6891,"KEGG":"R10402","RHEA_ID":33862,"DIRECTION":"BI","MASTER_ID":33859,"compounds":"(2S-3S)-versiconal hemiacetal <=> H2O + versicolorin B","pmd":18.011}
{"X":6892,"KEGG":"R10407","RHEA_ID":49259,"DIRECTION":"BI","MASTER_ID":49256,"compounds":"2-amino-2-deoxy-D-gluconate(out) + N(pros)-phospho-L-histidyl-[protein] <=> 2-amino-2-deoxy-D-gluconate 6-phosphate(in) + L-histidyl-[protein]","pmd":79.966}
{"X":6893,"KEGG":"R10408","RHEA_ID":38306,"DIRECTION":"BI","MASTER_ID":38303,"compounds":"2-amino-2-deoxy-D-gluconate 6-phosphate <=> 2-dehydro-3-deoxy-6-phospho-D-gluconate + NH4(+)","pmd":17.026}
{"X":6894,"KEGG":"R10412","RHEA_ID":37170,"DIRECTION":"BI","MASTER_ID":37167,"metacyc":"RXN-13748","compounds":"(2E,6E)-farnesol + NAD(+) <=> (2E,6E)-farnesal + H(+) + NADH","pmd":2.016}
{"X":6895,"KEGG":"R10412","RHEA_ID":37170,"DIRECTION":"BI","MASTER_ID":37167,"metacyc":"RXN-13748","compounds":"(2E,6E)-farnesol + NAD(+) <=> (2E,6E)-farnesal + H(+) + NADH","pmd":443.934}
{"X":6896,"KEGG":"R10413","RHEA_ID":36606,"DIRECTION":"BI","MASTER_ID":36603,"compounds":"2-oxoglutarate + L-enduracididine + O2 <=> (3S)-3-hydroxy-L-enduracididine + CO2 + succinate","pmd":27.995}
{"X":6897,"KEGG":"R10413","RHEA_ID":36606,"DIRECTION":"BI","MASTER_ID":36603,"compounds":"2-oxoglutarate + L-enduracididine + O2 <=> (3S)-3-hydroxy-L-enduracididine + CO2 + succinate","pmd":15.995}
{"X":6898,"KEGG":"R10414","RHEA_ID":35970,"DIRECTION":"BI","MASTER_ID":35967,"compounds":"fumitremorgin C + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 12alpha,13alpha-dihydroxyfumitremorgin C + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]","pmd":31.99}
{"X":6899,"KEGG":"R10415","RHEA_ID":36614,"DIRECTION":"BI","MASTER_ID":36611,"compounds":"(3S,5S)-carbapenam-3-caboxylate + 2-oxoglutarate + O2 <=> (5R)-carbapenem-3-carboxylate + CO2 + H2O + succinate","pmd":7.021}
{"X":6900,"KEGG":"R10415","RHEA_ID":36614,"DIRECTION":"BI","MASTER_ID":36611,"compounds":"(3S,5S)-carbapenam-3-caboxylate + 2-oxoglutarate + O2 <=> (5R)-carbapenem-3-carboxylate + CO2 + H2O + succinate","pmd":2.016}
{"X":6901,"KEGG":"R10416","RHEA_ID":35966,"DIRECTION":"BI","MASTER_ID":35963,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin A <=> fumitremorgin C + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]","pmd":2.016}
{"X":6902,"KEGG":"R10417","RHEA_ID":35838,"DIRECTION":"BI","MASTER_ID":35835,"compounds":"2'-dehydrokanamycin A + H(+) + NADPH <=> kanamycin A + NADP(+)","pmd":2.016}
{"X":6903,"KEGG":"R10417","RHEA_ID":35838,"DIRECTION":"BI","MASTER_ID":35835,"compounds":"2'-dehydrokanamycin A + H(+) + NADPH <=> kanamycin A + NADP(+)","pmd":261.861}
{"X":6904,"KEGG":"R10418","RHEA_ID":36594,"DIRECTION":"BI","MASTER_ID":36591,"compounds":"(S)-2-chloropropanoate + NADP(+) <=> 2-chloroacrylate + H(+) + NADPH","pmd":2.016}
{"X":6905,"KEGG":"R10418","RHEA_ID":36594,"DIRECTION":"BI","MASTER_ID":36591,"compounds":"(S)-2-chloropropanoate + NADP(+) <=> 2-chloroacrylate + H(+) + NADPH","pmd":638.101}
{"X":6906,"KEGG":"R10420","RHEA_ID":36570,"DIRECTION":"BI","MASTER_ID":36567,"compounds":"GDP-beta-L-colitose + NAD(+) <=> GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADH","pmd":2.016}
{"X":6907,"KEGG":"R10420","RHEA_ID":36570,"DIRECTION":"BI","MASTER_ID":36567,"compounds":"GDP-beta-L-colitose + NAD(+) <=> GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADH","pmd":93.045}
{"X":6908,"KEGG":"R10421","RHEA_ID":36566,"DIRECTION":"BI","MASTER_ID":36563,"compounds":"GDP-beta-L-colitose + NADP(+) <=> GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADPH","pmd":2.016}
{"X":6909,"KEGG":"R10421","RHEA_ID":36566,"DIRECTION":"BI","MASTER_ID":36563,"compounds":"GDP-beta-L-colitose + NADP(+) <=> GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADPH","pmd":173.012}
{"X":6910,"KEGG":"R10422","RHEA_ID":34782,"DIRECTION":"BI","MASTER_ID":34779,"metacyc":"RXN-13688","compounds":"a 3alpha-hydroxysteroid + NAD(+) <=> a 3-oxosteroid + H(+) + NADH","pmd":2.016}
{"X":6911,"KEGG":"R10422","RHEA_ID":34782,"DIRECTION":"BI","MASTER_ID":34779,"metacyc":"RXN-13688","compounds":"a 3alpha-hydroxysteroid + NAD(+) <=> a 3-oxosteroid + H(+) + NADH","pmd":389.887}
{"X":6912,"KEGG":"R10423","RHEA_ID":34786,"DIRECTION":"BI","MASTER_ID":34783,"metacyc":"RXN-13688","compounds":"a 3alpha-hydroxysteroid + NADP(+) <=> a 3-oxosteroid + H(+) + NADPH","pmd":2.016}
{"X":6913,"KEGG":"R10423","RHEA_ID":34786,"DIRECTION":"BI","MASTER_ID":34783,"metacyc":"RXN-13688","compounds":"a 3alpha-hydroxysteroid + NADP(+) <=> a 3-oxosteroid + H(+) + NADPH","pmd":469.854}
{"X":6914,"KEGG":"R10424","RHEA_ID":35798,"DIRECTION":"BI","MASTER_ID":35795,"compounds":"2'-deamino-2'-hydroxyneamine + UDP-alpha-D-kanosamine <=> H(+) + kanamycin A + UDP","pmd":80.833}
{"X":6915,"KEGG":"R10425","RHEA_ID":35786,"DIRECTION":"BI","MASTER_ID":35783,"compounds":"neamine + UDP-alpha-D-kanosamine <=> H(+) + kanamycin B + UDP","pmd":81.817}
{"X":6916,"KEGG":"R10426","RHEA_ID":35790,"DIRECTION":"BI","MASTER_ID":35787,"compounds":"paromamine + UDP-alpha-D-kanosamine <=> H(+) + kanamycin C + UDP","pmd":80.833}
{"X":6917,"KEGG":"R10427","RHEA_ID":35794,"DIRECTION":"BI","MASTER_ID":35791,"compounds":"2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-kanosamine <=> H(+) + kanamycin X + UDP","pmd":79.849}
{"X":6918,"KEGG":"R10428","RHEA_ID":15920,"DIRECTION":"BI","MASTER_ID":15917,"compounds":"an aldopyranose + NAD(+) <=> aldono-1,5-lactone + H(+) + NADH"}
{"X":6919,"KEGG":"R10429","RHEA_ID":36590,"DIRECTION":"BI","MASTER_ID":36587,"metacyc":"RXN-14233","compounds":"an aldopyranose + NADP(+) <=> aldono-1,5-lactone + H(+) + NADPH"}
{"X":6920,"KEGG":"R10430","RHEA_ID":26344,"DIRECTION":"BI","MASTER_ID":26341,"compounds":"L-selenocysteine + S-methyl-L-methionine <=> H(+) + L-methionine + Se-methyl-L-selenocysteine","pmd":15.024}
{"X":6921,"KEGG":"R10430","RHEA_ID":26344,"DIRECTION":"BI","MASTER_ID":26341,"compounds":"L-selenocysteine + S-methyl-L-methionine <=> H(+) + L-methionine + Se-methyl-L-selenocysteine","pmd":14.016}
{"X":6922,"KEGG":"R10431","RHEA_ID":36626,"DIRECTION":"BI","MASTER_ID":36623,"compounds":"3-phenylpyruvate + S-adenosyl-L-methionine <=> (3S)-2-oxo-3-phenylbutanoate + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6923,"KEGG":"R10432","RHEA_ID":36750,"DIRECTION":"BI","MASTER_ID":36747,"metacyc":"RXN-14558","compounds":"N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UDP-alpha-D-galactose <=> beta-D-Gal-(1->3)-alpha-D-GlcNAc-diphospho-di-trans,octa-cis-undecaprenol + H(+) + UDP","pmd":162.053}
{"X":6924,"KEGG":"R10433","RHEA_ID":36754,"DIRECTION":"BI","MASTER_ID":36751,"metacyc":"RXN-14557","compounds":"N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UDP-alpha-D-galactose <=> beta-D-Gal-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,octa-cis-undecaprenol + H(+) + UDP","pmd":162.053}
{"X":6925,"KEGG":"R10434","RHEA_ID":36758,"DIRECTION":"BI","MASTER_ID":36755,"metacyc":"RXN-14559","compounds":"N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UDP-alpha-D-glucose <=> beta-D-Glc-(1->3)-alpha-D-GlcNAc-diphospho-di-trans,octa-cis-undecaprenol + H(+) + UDP","pmd":162.053}
{"X":6926,"KEGG":"R10435","RHEA_ID":36762,"DIRECTION":"BI","MASTER_ID":36759,"compounds":"N-acetyl-alpha-D-galactosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UDP-N-acetyl-alpha-D-galactosamine <=> alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-di-trans,octa-cis-undecaprenol + H(+) + UDP","pmd":203.079}
{"X":6927,"KEGG":"R10436","RHEA_ID":36766,"DIRECTION":"BI","MASTER_ID":36763,"compounds":"alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-di-trans,octa-cis-undecaprenol + UDP-alpha-D-galactose <=> beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-di-trans,octa-cis-undecaprenol + H(+) + UDP","pmd":162.053}
{"X":6928,"KEGG":"R10437","RHEA_ID":52259,"DIRECTION":"BI","MASTER_ID":52256,"compounds":"a 7(1)-hydroxybacteriochlorophyllide c + H2O + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide c + H(+) + L-methionine","pmd":147.035}
{"X":6929,"KEGG":"R10439","RHEA_ID":36774,"DIRECTION":"BI","MASTER_ID":36771,"compounds":"beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-di-trans,octa-cis-undecaprenol + GDP-beta-L-fucose <=> alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)","pmd":146.058}
{"X":6930,"KEGG":"R10440","RHEA_ID":36778,"DIRECTION":"BI","MASTER_ID":36775,"compounds":"alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-di-trans,octa-cis-undecaprenol + UDP-alpha-D-galactose <=> alpha-D-Gal-(1->3)-[alpha-L-Fuc-(1->2)]-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-di-trans,octa-cis-undecaprenol + H(+) + UDP","pmd":162.053}
{"X":6931,"KEGG":"R10441","RHEA_ID":37370,"DIRECTION":"BI","MASTER_ID":37367,"compounds":"CDP-2,3-bis-(O-phytanyl)-sn-glycerol + L-serine <=> 2,3-bis-O-phytanyl-sn-glycero-3-phospho-L-serine + CMP + H(+)","pmd":218.009}
{"X":6932,"KEGG":"R10442","RHEA_ID":36802,"DIRECTION":"BI","MASTER_ID":36799,"metacyc":"NUCLEOSIDE-DIPHOSPHATASE-RXN","compounds":"a ribonucleoside 5'-diphosphate + H2O <=> a ribonucleoside 5'-phosphate + H(+) + phosphate"}
{"X":6933,"KEGG":"R10443","RHEA_ID":36798,"DIRECTION":"BI","MASTER_ID":36795,"compounds":"a ribonucleoside 5'-triphosphate + 2 H2O <=> a ribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate"}
{"X":6934,"KEGG":"R10444","RHEA_ID":36834,"DIRECTION":"BI","MASTER_ID":36831,"compounds":"2 caldariellaquinol + n H(+)(in) + O2 <=> 2 caldariellaquinone + n H(+)(out) + 2 H2O","pmd":2.016}
{"X":6935,"KEGG":"R10445","RHEA_ID":35978,"DIRECTION":"BI","MASTER_ID":35975,"compounds":"2-oxoglutarate + AH2 + fumitremorgin B + 2 O2 <=> A + CO2 + H2O + succinate + verruculogen","pmd":27.995}
{"X":6936,"KEGG":"R10445","RHEA_ID":35978,"DIRECTION":"BI","MASTER_ID":35975,"compounds":"2-oxoglutarate + AH2 + fumitremorgin B + 2 O2 <=> A + CO2 + H2O + succinate + verruculogen","pmd":31.99}
{"X":6937,"KEGG":"R10446","RHEA_ID":25775,"DIRECTION":"BI","MASTER_ID":25772,"compounds":"2-oxoglutarate + L-asparagine + O2 <=> (2S,3S)-3-hydroxyasparagine + CO2 + succinate","pmd":2.027}
{"X":6938,"KEGG":"R10446","RHEA_ID":25775,"DIRECTION":"BI","MASTER_ID":25772,"compounds":"2-oxoglutarate + L-asparagine + O2 <=> (2S,3S)-3-hydroxyasparagine + CO2 + succinate","pmd":14.027}
{"X":6939,"KEGG":"R10447","RHEA_ID":36102,"DIRECTION":"BI","MASTER_ID":36099,"compounds":"benzoate + S-adenosyl-L-methionine <=> methyl benzoate + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6940,"KEGG":"R10448","RHEA_ID":36098,"DIRECTION":"BI","MASTER_ID":36095,"compounds":"S-adenosyl-L-methionine + salicylate <=> methyl salicylate + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6941,"KEGG":"R10449","RHEA_ID":36122,"DIRECTION":"BI","MASTER_ID":36119,"compounds":"gibberellin A9 + S-adenosyl-L-methionine <=> O-methyl gibberellin A9 + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6942,"KEGG":"R10450","RHEA_ID":36110,"DIRECTION":"BI","MASTER_ID":36107,"compounds":"gibberellin A4 + S-adenosyl-L-methionine <=> O-methyl gibberellin A4 + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6943,"KEGG":"R10451","RHEA_ID":36106,"DIRECTION":"BI","MASTER_ID":36103,"compounds":"anthranilate + S-adenosyl-L-methionine <=> O-methyl anthranilate + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6944,"KEGG":"R10452","RHEA_ID":36134,"DIRECTION":"BI","MASTER_ID":36131,"compounds":"(indol-3-yl)acetate + S-adenosyl-L-methionine <=> methyl (indol-3-yl)acetate + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6945,"KEGG":"R10453","RHEA_ID":36702,"DIRECTION":"BI","MASTER_ID":36699,"compounds":"3-amino-4,7-dihydroxycoumarin + 3-dimethylallyl-4-hydroxybenzoate + ATP <=> 8-desmethylnovobiocic acid + AMP + diphosphate","pmd":140.969}
{"X":6946,"KEGG":"R10453","RHEA_ID":36702,"DIRECTION":"BI","MASTER_ID":36699,"compounds":"3-amino-4,7-dihydroxycoumarin + 3-dimethylallyl-4-hydroxybenzoate + ATP <=> 8-desmethylnovobiocic acid + AMP + diphosphate","pmd":125.875}
{"X":6947,"KEGG":"R10453","RHEA_ID":36702,"DIRECTION":"BI","MASTER_ID":36699,"compounds":"3-amino-4,7-dihydroxycoumarin + 3-dimethylallyl-4-hydroxybenzoate + ATP <=> 8-desmethylnovobiocic acid + AMP + diphosphate","pmd":154.026}
{"X":6948,"KEGG":"R10454","RHEA_ID":36654,"DIRECTION":"BI","MASTER_ID":36651,"compounds":"8-desmethylnovobiocic acid + S-adenosyl-L-methionine <=> H(+) + novobiocic acid + S-adenosyl-L-homocysteine","pmd":3}
{"X":6949,"KEGG":"R10455","RHEA_ID":36786,"DIRECTION":"BI","MASTER_ID":36783,"compounds":"L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine <=> 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine","pmd":101.048}
{"X":6950,"KEGG":"R10456","RHEA_ID":35946,"DIRECTION":"BI","MASTER_ID":35943,"compounds":"brevianamide F + dimethylallyl diphosphate <=> deoxybrevianamide E + diphosphate","pmd":105.189}
{"X":6951,"KEGG":"R10456","RHEA_ID":35946,"DIRECTION":"BI","MASTER_ID":35943,"compounds":"brevianamide F + dimethylallyl diphosphate <=> deoxybrevianamide E + diphosphate","pmd":68.063}
{"X":6952,"KEGG":"R10457","RHEA_ID":35974,"DIRECTION":"BI","MASTER_ID":35971,"compounds":"12alpha,13alpha-dihydroxyfumitremorgin C + dimethylallyl diphosphate <=> diphosphate + fumitremorgin B","pmd":233.236}
{"X":6953,"KEGG":"R10457","RHEA_ID":35974,"DIRECTION":"BI","MASTER_ID":35971,"compounds":"12alpha,13alpha-dihydroxyfumitremorgin C + dimethylallyl diphosphate <=> diphosphate + fumitremorgin B","pmd":68.063}
{"X":6954,"KEGG":"R10461","RHEA_ID":36266,"DIRECTION":"BI","MASTER_ID":36263,"compounds":"hydroxyurea + O-acetyl-L-serine <=> acetate + H(+) + O-ureido-L-serine","pmd":16.006}
{"X":6955,"KEGG":"R10462","RHEA_ID":42067,"DIRECTION":"BI","MASTER_ID":42064,"metacyc":"RXN-14337","compounds":"ATP + GTP <=> 2',3'-cGAMP + 2 diphosphate","pmd":167.104}
{"X":6956,"KEGG":"R10462","RHEA_ID":42067,"DIRECTION":"BI","MASTER_ID":42064,"metacyc":"RXN-14337","compounds":"ATP + GTP <=> 2',3'-cGAMP + 2 diphosphate","pmd":151.109}
{"X":6957,"KEGG":"R10463","RHEA_ID":36410,"DIRECTION":"BI","MASTER_ID":36407,"ecocyc":"RXN-14569","metacyc":"RXN-14569","compounds":"ATP + hydrogencarbonate + L-threonine <=> diphosphate + H2O + L-threonylcarbamoyladenylate","pmd":373.042}
{"X":6958,"KEGG":"R10463","RHEA_ID":36410,"DIRECTION":"BI","MASTER_ID":36407,"ecocyc":"RXN-14569","metacyc":"RXN-14569","compounds":"ATP + hydrogencarbonate + L-threonine <=> diphosphate + H2O + L-threonylcarbamoyladenylate","pmd":14.895}
{"X":6959,"KEGG":"R10464","RHEA_ID":36826,"DIRECTION":"BI","MASTER_ID":36823,"compounds":"1D-myo-inositol 3-phosphate + CDP-2,3-bis-(O-phytanyl)-sn-glycerol <=> CMP + H(+) + saturated 1-archaetidyl-1D-myo-inositol 3-phosphate","pmd":63.022}
{"X":6960,"KEGG":"R10465","RHEA_ID":36790,"DIRECTION":"BI","MASTER_ID":36787,"metacyc":"RXN-14571","compounds":"di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-galactosamine <=> N-acetyl-alpha-D-galactosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UMP","pmd":522.63}
{"X":6961,"KEGG":"R10465","RHEA_ID":36790,"DIRECTION":"BI","MASTER_ID":36787,"metacyc":"RXN-14571","compounds":"di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-galactosamine <=> N-acetyl-alpha-D-galactosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UMP","pmd":283.046}
{"X":6962,"KEGG":"R10466","RHEA_ID":36794,"DIRECTION":"BI","MASTER_ID":36791,"compounds":"H2O + N(omega)-hydroxy-L-arginine <=> hydroxyurea + L-ornithine","pmd":58.017}
{"X":6963,"KEGG":"R10467","RHEA_ID":37874,"DIRECTION":"BI","MASTER_ID":37871,"compounds":"2-heptyl-4(1H)-quinolone + H(+) + NADH + O2 <=> 2-heptyl-3-hydroxy-4(1H)-quinolone + H2O + NAD(+)","pmd":15.995}
{"X":6964,"KEGG":"R10467","RHEA_ID":37874,"DIRECTION":"BI","MASTER_ID":37871,"compounds":"2-heptyl-4(1H)-quinolone + H(+) + NADH + O2 <=> 2-heptyl-3-hydroxy-4(1H)-quinolone + H2O + NAD(+)","pmd":405.968}
{"X":6965,"KEGG":"R10468","RHEA_ID":37042,"DIRECTION":"BI","MASTER_ID":37039,"compounds":"5 AH2 + 2 H(+) + heme b + 4 O2 <=> 5 A + delta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O","pmd":17.935}
{"X":6966,"KEGG":"R10469","RHEA_ID":26320,"DIRECTION":"BI","MASTER_ID":26317,"compounds":"2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate <=> 3-amino-4-hydroxybenzoate + H(+) + 2 H2O + phosphate","pmd":133.998}
{"X":6967,"KEGG":"R10470","RHEA_ID":36714,"DIRECTION":"BI","MASTER_ID":36711,"compounds":"ATP + H(+) + H2O + O-ureido-D-serine <=> ADP + CO2 + D-cycloserine + NH4(+) + phosphate","pmd":61.016}
{"X":6968,"KEGG":"R10470","RHEA_ID":36714,"DIRECTION":"BI","MASTER_ID":36711,"compounds":"ATP + H(+) + H2O + O-ureido-D-serine <=> ADP + CO2 + D-cycloserine + NH4(+) + phosphate","pmd":79.966}
{"X":6969,"KEGG":"R10472","RHEA_ID":36646,"DIRECTION":"BI","MASTER_ID":36643,"compounds":"emodin + S-adenosyl-L-methionine <=> H(+) + questin + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6970,"KEGG":"R10473","RHEA_ID":36150,"DIRECTION":"BI","MASTER_ID":36147,"compounds":"acetyl-CoA + benzyl alcohol <=> benzyl acetate + CoA","pmd":42.011}
{"X":6971,"KEGG":"R10474","RHEA_ID":36154,"DIRECTION":"BI","MASTER_ID":36151,"metacyc":"RXN-14454","compounds":"acetyl-CoA + cinnamyl alcohol <=> cinnamyl acetate + CoA","pmd":42.011}
{"X":6972,"KEGG":"R10474","RHEA_ID":36154,"DIRECTION":"BI","MASTER_ID":36151,"metacyc":"RXN-14454","compounds":"acetyl-CoA + cinnamyl alcohol <=> cinnamyl acetate + CoA","pmd":42.01}
{"X":6973,"KEGG":"R10475","RHEA_ID":35674,"DIRECTION":"BI","MASTER_ID":35671,"compounds":"(S)-5'-oxoaverantin + H(+) <=> (1'S,5'S)-averufin + H2O","pmd":18.011}
{"X":6974,"KEGG":"R10479","RHEA_ID":35746,"DIRECTION":"BI","MASTER_ID":35743,"compounds":"H(+) + NADPH + O2 + versicolorin B <=> 2 H2O + NADP(+) + versicolorin A","pmd":2.016}
{"X":6975,"KEGG":"R10479","RHEA_ID":35746,"DIRECTION":"BI","MASTER_ID":35743,"compounds":"H(+) + NADPH + O2 + versicolorin B <=> 2 H2O + NADP(+) + versicolorin A","pmd":407.048}
{"X":6976,"KEGG":"R10484","RHEA_ID":36686,"DIRECTION":"BI","MASTER_ID":36683,"metacyc":"RXN-14554","compounds":"hexadecanoyl-CoA + L-cysteinyl-[protein] <=> CoA + S-hexadecanoyl-L-cysteinyl-[protein]"}
{"X":6977,"KEGG":"R10485","RHEA_ID":36666,"DIRECTION":"BI","MASTER_ID":36663,"compounds":"(S)-1-pyrroline-5-carboxylate + H(+) + H2O + malonyl-CoA <=> (2S,5S)-5-carboxymethylproline + CO2 + CoA","pmd":86}
{"X":6978,"KEGG":"R10485","RHEA_ID":36666,"DIRECTION":"BI","MASTER_ID":36663,"compounds":"(S)-1-pyrroline-5-carboxylate + H(+) + H2O + malonyl-CoA <=> (2S,5S)-5-carboxymethylproline + CO2 + CoA","pmd":60.021}
{"X":6979,"KEGG":"R10486","RHEA_ID":36298,"DIRECTION":"BI","MASTER_ID":36295,"compounds":"alpha-maltose 6'-phosphate + H2O <=> D-maltose + phosphate","pmd":79.966}
{"X":6980,"KEGG":"R10487","RHEA_ID":37830,"DIRECTION":"BI","MASTER_ID":37827,"compounds":"(S)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 <=> 2,4-dichlorophenol + CO2 + pyruvate + succinate","pmd":72.021}
{"X":6981,"KEGG":"R10487","RHEA_ID":37830,"DIRECTION":"BI","MASTER_ID":37827,"compounds":"(S)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 <=> 2,4-dichlorophenol + CO2 + pyruvate + succinate","pmd":15.942}
{"X":6982,"KEGG":"R10488","RHEA_ID":36710,"DIRECTION":"BI","MASTER_ID":36707,"metacyc":"RXN-14459","compounds":"O-ureido-L-serine <=> O-ureido-D-serine","pmd":0}
{"X":6983,"KEGG":"R10493","RHEA_ID":36066,"DIRECTION":"BI","MASTER_ID":36063,"compounds":"(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + kunzeaol","pmd":159.933}
{"X":6984,"KEGG":"R10494","RHEA_ID":36074,"DIRECTION":"BI","MASTER_ID":36071,"metacyc":"RXN-14343","compounds":"6-tuliposide A <=> D-glucose + tulipalin A","pmd":98.037}
{"X":6985,"KEGG":"R10495","RHEA_ID":35094,"DIRECTION":"BI","MASTER_ID":35091,"compounds":"anthranilate + 2 ATP + L-phenylalanine + S-adenosyl-L-methionine <=> 2 AMP + cyclopeptine + 2 diphosphate + 2 H(+) + S-adenosyl-L-homocysteine","pmd":143.073}
{"X":6986,"KEGG":"R10495","RHEA_ID":35094,"DIRECTION":"BI","MASTER_ID":35091,"compounds":"anthranilate + 2 ATP + L-phenylalanine + S-adenosyl-L-methionine <=> 2 AMP + cyclopeptine + 2 diphosphate + 2 H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6987,"KEGG":"R10495","RHEA_ID":35094,"DIRECTION":"BI","MASTER_ID":35091,"compounds":"anthranilate + 2 ATP + L-phenylalanine + S-adenosyl-L-methionine <=> 2 AMP + cyclopeptine + 2 diphosphate + 2 H(+) + S-adenosyl-L-homocysteine","pmd":115.042}
{"X":6988,"KEGG":"R10495","RHEA_ID":35094,"DIRECTION":"BI","MASTER_ID":35091,"compounds":"anthranilate + 2 ATP + L-phenylalanine + S-adenosyl-L-methionine <=> 2 AMP + cyclopeptine + 2 diphosphate + 2 H(+) + S-adenosyl-L-homocysteine","pmd":122.874}
{"X":6989,"KEGG":"R10496","RHEA_ID":43611,"DIRECTION":"BI","MASTER_ID":43608,"compounds":"agmatine + ATP + cytidine(34) in tRNA(Ile2) + H2O <=> 2-agmatinylcytidine(34) in tRNA(Ile2) + AMP + 2 H(+) + 2 phosphate","pmd":159.933}
{"X":6990,"KEGG":"R10496","RHEA_ID":43611,"DIRECTION":"BI","MASTER_ID":43608,"compounds":"agmatine + ATP + cytidine(34) in tRNA(Ile2) + H2O <=> 2-agmatinylcytidine(34) in tRNA(Ile2) + AMP + 2 H(+) + 2 phosphate","pmd":216.941}
{"X":6991,"KEGG":"R10497","RHEA_ID":43787,"DIRECTION":"BI","MASTER_ID":43784,"compounds":"adenosine(2142) in 25S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyladenosine(2142) in 25S rRNA + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6992,"KEGG":"R10497","RHEA_ID":43795,"DIRECTION":"BI","MASTER_ID":43792,"compounds":"adenosine(645) in 25S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyladenosine(645) in 25S rRNA + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6993,"KEGG":"R10498","RHEA_ID":36638,"DIRECTION":"BI","MASTER_ID":36635,"compounds":"4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine <=> 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":6994,"KEGG":"R10509","RHEA_ID":32710,"DIRECTION":"BI","MASTER_ID":32707,"compounds":"(2E)-geranyl diphosphate <=> (2R,4S)-bornyl diphosphate","pmd":0}
{"X":6995,"KEGG":"R10510","RHEA_ID":37366,"DIRECTION":"BI","MASTER_ID":37363,"compounds":"5 AH2 + 2 H(+) + heme b + 4 O2 <=> 5 A + beta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O","pmd":17.935}
{"X":6996,"KEGG":"R10511","RHEA_ID":38194,"DIRECTION":"BI","MASTER_ID":38191,"compounds":"3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone <=> 17beta-estradiol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]","pmd":16.031}
{"X":6997,"KEGG":"R10512","RHEA_ID":38454,"DIRECTION":"BI","MASTER_ID":38451,"metacyc":"RXN-14694","compounds":"hydrogen sulfide + NADP(+) + n sulfur <=> NADPH + (n+1) sulfur"}
{"X":6998,"KEGG":"R10514","RHEA_ID":36814,"DIRECTION":"BI","MASTER_ID":36811,"metacyc":"RXN-14698","compounds":"acetyl-CoA + GDP-alpha-D-perosamine <=> CoA + GDP-N-acetyl-alpha-D-perosamine + H(+)","pmd":42.011}
{"X":6999,"KEGG":"R10515","RHEA_ID":38198,"DIRECTION":"BI","MASTER_ID":38195,"compounds":"androst-4-ene-3,17-dione + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> estrone + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]","pmd":16.031}
{"X":7000,"KEGG":"R10516","RHEA_ID":42319,"DIRECTION":"BI","MASTER_ID":42316,"compounds":"a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] <=> an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":7001,"KEGG":"R10517","RHEA_ID":37802,"DIRECTION":"BI","MASTER_ID":37799,"compounds":"2 H(+) + 2 NADH + O2 <=> 2 H2O + 2 NAD(+)"}
{"X":7002,"KEGG":"R10519","RHEA_ID":37550,"DIRECTION":"BI","MASTER_ID":37547,"compounds":"D-glucose 6-phosphate + NAD(+) <=> 3-dehydro-D-glucose 6-phosphate + H(+) + NADH","pmd":406.103}
{"X":7003,"KEGG":"R10519","RHEA_ID":37550,"DIRECTION":"BI","MASTER_ID":37547,"compounds":"D-glucose 6-phosphate + NAD(+) <=> 3-dehydro-D-glucose 6-phosphate + H(+) + NADH","pmd":2.016}
{"X":7004,"KEGG":"R10521","RHEA_ID":37546,"DIRECTION":"BI","MASTER_ID":37543,"compounds":"2-amino-5-chlorophenol + O2 <=> 2-amino-5-chloromuconate 6-semialdehyde","pmd":31.99}
{"X":7005,"KEGG":"R10522","RHEA_ID":37902,"DIRECTION":"BI","MASTER_ID":37899,"compounds":"2-oxoglutarate + 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + O2 <=> 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + CO2 + succinate","pmd":27.995}
{"X":7006,"KEGG":"R10523","RHEA_ID":38478,"DIRECTION":"BI","MASTER_ID":38475,"compounds":"L-histidine + S-adenosyl-L-methionine <=> H(+) + N(alpha)-methyl-L-histidine + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7007,"KEGG":"R10524","RHEA_ID":38482,"DIRECTION":"BI","MASTER_ID":38479,"compounds":"N(alpha)-methyl-L-histidine + S-adenosyl-L-methionine <=> H(+) + N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7008,"KEGG":"R10525","RHEA_ID":47419,"DIRECTION":"BI","MASTER_ID":47416,"metacyc":"RXN-9603","compounds":"an NDP-alpha-D-glucose + D-glucose <=> a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose + H(+)","pmd":162.053}
{"X":7009,"KEGG":"R10526","RHEA_ID":37474,"DIRECTION":"BI","MASTER_ID":37471,"metacyc":"RXN-14718","compounds":"3-methylbutanoyl-CoA + S-adenosyl-L-methionine <=> CoA + H(+) + N-isovaleryl-L-homoserine lactone + S-methyl-5'-thioadenosine","pmd":101.048}
{"X":7010,"KEGG":"R10526","RHEA_ID":37474,"DIRECTION":"BI","MASTER_ID":37471,"metacyc":"RXN-14718","compounds":"3-methylbutanoyl-CoA + S-adenosyl-L-methionine <=> CoA + H(+) + N-isovaleryl-L-homoserine lactone + S-methyl-5'-thioadenosine","pmd":84.058}
{"X":7011,"KEGG":"R10527","RHEA_ID":37834,"DIRECTION":"BI","MASTER_ID":37831,"compounds":"(S)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2 <=> 2-methyl-4-chlorophenol + CO2 + pyruvate + succinate","pmd":4.003}
{"X":7012,"KEGG":"R10527","RHEA_ID":37834,"DIRECTION":"BI","MASTER_ID":37831,"compounds":"(S)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2 <=> 2-methyl-4-chlorophenol + CO2 + pyruvate + succinate","pmd":72.021}
{"X":7013,"KEGG":"R10529","RHEA_ID":37494,"DIRECTION":"BI","MASTER_ID":37491,"metacyc":"RXN-14719","compounds":"4-coumaroyl-CoA + S-adenosyl-L-methionine <=> CoA + H(+) + N-(4-coumaroyl)-L-homoserine lactone + S-methyl-5'-thioadenosine","pmd":101.048}
{"X":7014,"KEGG":"R10529","RHEA_ID":37494,"DIRECTION":"BI","MASTER_ID":37491,"metacyc":"RXN-14719","compounds":"4-coumaroyl-CoA + S-adenosyl-L-methionine <=> CoA + H(+) + N-(4-coumaroyl)-L-homoserine lactone + S-methyl-5'-thioadenosine","pmd":146.037}
{"X":7015,"KEGG":"R10530","RHEA_ID":37898,"DIRECTION":"BI","MASTER_ID":37895,"compounds":"H2O + protodioscin <=> 26-deglucoprotodioscin + D-glucose"}
{"X":7016,"KEGG":"R10531","RHEA_ID":35030,"DIRECTION":"BI","MASTER_ID":35027,"compounds":"ATP + H2O + tungstate(in) <=> ADP + H(+) + phosphate + tungstate(out)","pmd":79.966}
{"X":7017,"KEGG":"R10532","RHEA_ID":38106,"DIRECTION":"BI","MASTER_ID":38103,"compounds":"L-galactonate <=> 2-dehydro-3-deoxy-L-galactonate + H2O","pmd":18.011}
{"X":7018,"KEGG":"R10533","RHEA_ID":38158,"DIRECTION":"BI","MASTER_ID":38155,"compounds":"all-trans-geranylgeranyl diphosphate + H2O <=> (6E,10E)-geranyllinalool + diphosphate","pmd":159.933}
{"X":7019,"KEGG":"R10534","RHEA_ID":38150,"DIRECTION":"BI","MASTER_ID":38147,"compounds":"carbon disulfide + H2O <=> carbonyl sulfide + H(+) + hydrogen sulfide"}
{"X":7020,"KEGG":"R10535","RHEA_ID":38154,"DIRECTION":"BI","MASTER_ID":38151,"compounds":"carbonyl sulfide + H2O <=> CO2 + H(+) + hydrogen sulfide"}
{"X":7021,"KEGG":"R10536","RHEA_ID":36818,"DIRECTION":"BI","MASTER_ID":36815,"metacyc":"RXN-14533","compounds":"dTDP-alpha-D-fucose <=> dTDP-alpha-D-fucofuranose","pmd":0}
{"X":7022,"KEGG":"R10537","RHEA_ID":13972,"DIRECTION":"BI","MASTER_ID":13969,"compounds":"(RNA)-3'-(3'-phospho-ribonucleoside) + GTP <=> (RNA)-3'-(2',3'-cyclophospho)-ribonucleoside + diphosphate + GMP","pmd":159.933}
{"X":7023,"KEGG":"R10538","RHEA_ID":38146,"DIRECTION":"BI","MASTER_ID":38143,"metacyc":"RXN-14638","compounds":"carbon disulfide + 2 H2O <=> CO2 + 2 H(+) + 2 hydrogen sulfide"}
{"X":7024,"KEGG":"R10539","RHEA_ID":37818,"DIRECTION":"BI","MASTER_ID":37815,"compounds":"(R)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2 <=> 2-methyl-4-chlorophenol + CO2 + pyruvate + succinate","pmd":4.003}
{"X":7025,"KEGG":"R10539","RHEA_ID":37818,"DIRECTION":"BI","MASTER_ID":37815,"compounds":"(R)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2 <=> 2-methyl-4-chlorophenol + CO2 + pyruvate + succinate","pmd":72.021}
{"X":7026,"KEGG":"R10540","RHEA_ID":38582,"DIRECTION":"BI","MASTER_ID":38579,"compounds":"dammarenediol-II + O2 + reduced [NADPH--hemoprotein reductase] <=> (20S)-protopanaxadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":7027,"KEGG":"R10541","RHEA_ID":36378,"DIRECTION":"BI","MASTER_ID":36375,"ecocyc":"RXN-14552","metacyc":"RXN-14552","compounds":"ATP + carbamoyl phosphate + H2O <=> carbamoyl adenylate + diphosphate + phosphate","pmd":249.086}
{"X":7028,"KEGG":"R10541","RHEA_ID":36378,"DIRECTION":"BI","MASTER_ID":36375,"ecocyc":"RXN-14552","metacyc":"RXN-14552","compounds":"ATP + carbamoyl phosphate + H2O <=> carbamoyl adenylate + diphosphate + phosphate","pmd":116.927}
{"X":7029,"KEGG":"R10542","RHEA_ID":37826,"DIRECTION":"BI","MASTER_ID":37823,"compounds":"(R)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 <=> 2,4-dichlorophenol + CO2 + pyruvate + succinate","pmd":15.942}
{"X":7030,"KEGG":"R10542","RHEA_ID":37826,"DIRECTION":"BI","MASTER_ID":37823,"compounds":"(R)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 <=> 2,4-dichlorophenol + CO2 + pyruvate + succinate","pmd":72.021}
{"X":7031,"KEGG":"R10543","RHEA_ID":36386,"DIRECTION":"BI","MASTER_ID":36383,"compounds":"carbamoyl adenylate + tobramycin <=> AMP + H(+) + nebramycin 5'","pmd":43.006}
{"X":7032,"KEGG":"R10544","RHEA_ID":36390,"DIRECTION":"BI","MASTER_ID":36387,"compounds":"carbamoyl adenylate + kanamycin A <=> 6''-O-carbamoylkanamycin A + AMP + H(+)","pmd":43.006}
{"X":7033,"KEGG":"R10545","RHEA_ID":37894,"DIRECTION":"BI","MASTER_ID":37891,"compounds":"aclacinomycin T + H2O <=> 15-demethylaclacinomycin T + methanol","pmd":14.016}
{"X":7034,"KEGG":"R10546","RHEA_ID":37110,"DIRECTION":"BI","MASTER_ID":37107,"compounds":"7-methyl-GMP + H2O <=> N(7)-methylguanosine + phosphate","pmd":79.966}
{"X":7035,"KEGG":"R10547","RHEA_ID":37558,"DIRECTION":"BI","MASTER_ID":37555,"compounds":"D-kanosamine 6-phosphate + H2O <=> kanosamine + phosphate","pmd":79.966}
{"X":7036,"KEGG":"R10548","RHEA_ID":37470,"DIRECTION":"BI","MASTER_ID":37467,"compounds":"1-diphospho-myo-inositol 2,3,4,5,6-pentakisphosphate + ATP + H(+) <=> 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP","pmd":79.966}
{"X":7037,"KEGG":"R10550","RHEA_ID":38110,"DIRECTION":"BI","MASTER_ID":38107,"metacyc":"RXN-11381","compounds":"2-dehydro-3-deoxy-L-galactonate <=> L-glyceraldehyde + pyruvate"}
{"X":7038,"KEGG":"R10552","RHEA_ID":36350,"DIRECTION":"BI","MASTER_ID":36347,"compounds":"N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine <=> 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + CO2 + H2O + L-methionine","pmd":147.035}
{"X":7039,"KEGG":"R10554","RHEA_ID":34106,"DIRECTION":"BI","MASTER_ID":34103,"compounds":"N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol <=> N-acetyl-alpha-D-galactosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol"}
{"X":7040,"KEGG":"R10555","RHEA_ID":32246,"DIRECTION":"BI","MASTER_ID":32243,"compounds":"alpha-D-ribose 1,5-bisphosphate <=> D-ribulose 1,5-bisphosphate","pmd":0}
{"X":7041,"KEGG":"R10556","RHEA_ID":36706,"DIRECTION":"BI","MASTER_ID":36703,"compounds":"(2S,5S)-5-carboxymethylproline + ATP <=> (3S,5S)-carbapenam-3-caboxylate + AMP + diphosphate + H(+)","pmd":159.933}
{"X":7042,"KEGG":"R10556","RHEA_ID":36706,"DIRECTION":"BI","MASTER_ID":36703,"compounds":"(2S,5S)-5-carboxymethylproline + ATP <=> (3S,5S)-carbapenam-3-caboxylate + AMP + diphosphate + H(+)","pmd":18.011}
{"X":7043,"KEGG":"R10557","RHEA_ID":34402,"DIRECTION":"BI","MASTER_ID":34399,"compounds":"9-cis-beta-carotene + O2 <=> 9-cis-10'-apo-beta-carotenal + beta-ionone","pmd":160.162}
{"X":7044,"KEGG":"R10558","RHEA_ID":34406,"DIRECTION":"BI","MASTER_ID":34403,"compounds":"9-cis-10'-apo-beta-carotenal + 2 O2 <=> (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal + carlactone","pmd":74.088}
{"X":7045,"KEGG":"R10559","RHEA_ID":26392,"DIRECTION":"BI","MASTER_ID":26389,"compounds":"all-trans-beta-carotene + O2 <=> all-trans-10'-apo-beta-carotenal + beta-ionone","pmd":160.162}
{"X":7046,"KEGG":"R10560","RHEA_ID":26404,"DIRECTION":"BI","MASTER_ID":26401,"compounds":"all-trans-10'-apo-beta-carotenal + O2 <=> (2E,4E,6E)-4-methylocta-2,4,6-trienedial + 13-apo-beta-carotenone","pmd":118.078}
{"X":7047,"KEGG":"R10561","RHEA_ID":40958,"DIRECTION":"BI","MASTER_ID":40955,"compounds":"(R)-5-phosphomevalonate + ATP <=> ADP + CO2 + isopentenyl phosphate + phosphate","pmd":79.966}
{"X":7048,"KEGG":"R10561","RHEA_ID":40958,"DIRECTION":"BI","MASTER_ID":40955,"compounds":"(R)-5-phosphomevalonate + ATP <=> ADP + CO2 + isopentenyl phosphate + phosphate","pmd":62}
{"X":7049,"KEGG":"R10562","RHEA_ID":13548,"DIRECTION":"BI","MASTER_ID":13545,"compounds":"(6E,10E)-geranyllinalool + O2 + reduced [NADPH--hemoprotein reductase] <=> (3E,7E)-4,8,12-trimethyltrideca 1,3,7,11-tetraene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]","pmd":72.058}
{"X":7050,"KEGG":"R10563","RHEA_ID":38114,"DIRECTION":"BI","MASTER_ID":38111,"compounds":"glycerol + NADP(+) <=> H(+) + L-glyceraldehyde + NADPH"}
{"X":7051,"KEGG":"R10564","RHEA_ID":31558,"DIRECTION":"BI","MASTER_ID":31555,"metacyc":"R125-RXN","compounds":"(5S)-5-amino-3-oxo-hexanoate + acetyl-CoA <=> (3S)-3-aminobutanoyl-CoA + acetoacetate","pmd":43.042}
{"X":7052,"KEGG":"R10572","RHEA_ID":39666,"DIRECTION":"BI","MASTER_ID":39663,"metacyc":"RXN-14920","compounds":"a quinol + H(+) + oxidized coenzyme F420-(gamma-Glu)(n) <=> a quinone + reduced coenzyme F420-(gamma-Glu)(n)","pmd":2.016}
{"X":7053,"KEGG":"R10573","RHEA_ID":39886,"DIRECTION":"BI","MASTER_ID":39883,"compounds":"dTDP-6-deoxy-alpha-D-allose + NADP(+) <=> dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADPH","pmd":2.016}
{"X":7054,"KEGG":"R10573","RHEA_ID":39886,"DIRECTION":"BI","MASTER_ID":39883,"compounds":"dTDP-6-deoxy-alpha-D-allose + NADP(+) <=> dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADPH","pmd":198.018}
{"X":7055,"KEGG":"R10574","RHEA_ID":39670,"DIRECTION":"BI","MASTER_ID":39667,"metacyc":"RXN-15037","compounds":"a secondary alcohol + H(+) + oxidized coenzyme F420-(gamma-Glu)(n) <=> a ketone + reduced coenzyme F420-(gamma-Glu)(n)","pmd":2.016}
{"X":7056,"KEGG":"R10575","RHEA_ID":38298,"DIRECTION":"BI","MASTER_ID":38295,"compounds":"(R)-2-hydroxyglutarate + A <=> 2-oxoglutarate + AH2","pmd":2.016}
{"X":7057,"KEGG":"R10576","RHEA_ID":37910,"DIRECTION":"BI","MASTER_ID":37907,"compounds":"(9Z)-octadecenoate + O2 <=> (8E,10S)-10-hydroperoxy-octadeca-8-enoate","pmd":31.99}
{"X":7058,"KEGG":"R10577","RHEA_ID":37922,"DIRECTION":"BI","MASTER_ID":37919,"compounds":"(9Z,12Z)-octadecadienoate + O2 <=> (8E,10S,12Z)-10-hydroperoxyoctadeca-8,12-dienoate","pmd":31.99}
{"X":7059,"KEGG":"R10578","RHEA_ID":37926,"DIRECTION":"BI","MASTER_ID":37923,"compounds":"(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (8E,10S,12Z,15Z)-10-hydroperoxyoctadeca-8,12,15-trienoate","pmd":31.99}
{"X":7060,"KEGG":"R10579","RHEA_ID":38450,"DIRECTION":"BI","MASTER_ID":38447,"compounds":"4-O-(beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + H2O <=> 4-O-(beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose","pmd":245.09}
{"X":7061,"KEGG":"R10580","RHEA_ID":38914,"DIRECTION":"BI","MASTER_ID":38911,"compounds":"avenacoside B + H2O <=> 26-desgluco-avenacoside B + D-glucose"}
{"X":7062,"KEGG":"R10581","RHEA_ID":36830,"DIRECTION":"BI","MASTER_ID":36827,"compounds":"dioscin + 3 H2O <=> D-glucose + diosgenin + 2 L-rhamnopyranose","pmd":454.169}
{"X":7063,"KEGG":"R10582","RHEA_ID":38942,"DIRECTION":"BI","MASTER_ID":38939,"compounds":"dioscin + 2 H2O <=> diosgenin 3-beta-D-glucoside + 2 L-rhamnopyranose","pmd":292.116}
{"X":7064,"KEGG":"R10583","RHEA_ID":38322,"DIRECTION":"BI","MASTER_ID":38319,"metacyc":"RXN-14939","compounds":"chorismate + H2O <=> (3R,4R)-3,4-dihydroxy-3,4-dihydrobenzoate + pyruvate","pmd":70.005}
{"X":7065,"KEGG":"R10584","RHEA_ID":33994,"DIRECTION":"BI","MASTER_ID":33991,"compounds":"(2E,6E)-farnesyl diphosphate <=> alpha-copaene + diphosphate","pmd":177.943}
{"X":7066,"KEGG":"R10585","RHEA_ID":33986,"DIRECTION":"BI","MASTER_ID":33983,"compounds":"(+)-copalyl diphosphate <=> diphosphate + miltiradiene","pmd":177.943}
{"X":7067,"KEGG":"R10586","RHEA_ID":36906,"DIRECTION":"BI","MASTER_ID":36903,"compounds":"7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine <=> 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7068,"KEGG":"R10587","RHEA_ID":37122,"DIRECTION":"BI","MASTER_ID":37119,"compounds":"7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + CO2 + S-adenosyl-L-methionine <=> 2 H(+) + S-adenosyl-L-homocysteine + wybutosine(37) in tRNA(Phe)","pmd":14.016}
{"X":7069,"KEGG":"R10588","RHEA_ID":37906,"DIRECTION":"BI","MASTER_ID":37903,"compounds":"6-hydroxytryprostatin B + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + tryprostatin A","pmd":14.016}
{"X":7070,"KEGG":"R10589","RHEA_ID":50399,"DIRECTION":"BI","MASTER_ID":50396,"compounds":"(2-aminobenzoyl)acetate + H(+) + octanoyl-CoA <=> 2-heptyl-4(1H)-quinolone + CO2 + CoA + H2O","pmd":57.037}
{"X":7071,"KEGG":"R10589","RHEA_ID":50399,"DIRECTION":"BI","MASTER_ID":50396,"compounds":"(2-aminobenzoyl)acetate + H(+) + octanoyl-CoA <=> 2-heptyl-4(1H)-quinolone + CO2 + CoA + H2O","pmd":119.037}
{"X":7072,"KEGG":"R10590","RHEA_ID":50403,"DIRECTION":"BI","MASTER_ID":50400,"compounds":"L-cysteinyl-[PqsC protein] + octanoyl-CoA <=> CoA + S-octanoyl-L-cysteinyl-[PqsC protein]","pmd":126.105}
{"X":7073,"KEGG":"R10591","RHEA_ID":22275,"DIRECTION":"BI","MASTER_ID":22272,"compounds":"(20S)-protopanaxadiol + O2 + reduced [NADPH--hemoprotein reductase] <=> (20S)-protopanaxatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":7074,"KEGG":"R10592","RHEA_ID":39118,"DIRECTION":"BI","MASTER_ID":39115,"compounds":"4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NAD(+) <=> 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADH"}
{"X":7075,"KEGG":"R10593","RHEA_ID":39114,"DIRECTION":"BI","MASTER_ID":39111,"compounds":"4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NADP(+) <=> 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADPH","pmd":618.052}
{"X":7076,"KEGG":"R10593","RHEA_ID":39114,"DIRECTION":"BI","MASTER_ID":39111,"compounds":"4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NADP(+) <=> 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADPH","pmd":2.016}
{"X":7077,"KEGG":"R10594","RHEA_ID":38590,"DIRECTION":"BI","MASTER_ID":38587,"metacyc":"RXN-14837","compounds":"UDP-alpha-D-glucose + vancomycin aglycone <=> devancoaminyl-vancomycin + UDP","pmd":162.053}
{"X":7078,"KEGG":"R10595","RHEA_ID":38594,"DIRECTION":"BI","MASTER_ID":38591,"metacyc":"RXN-14838","compounds":"devancoaminyl-vancomycin + dTDP-beta-L-4-epi-vancosamine <=> chloroorienticin B + dTDP + H(+)","pmd":143.095}
{"X":7079,"KEGG":"R10596","RHEA_ID":37666,"DIRECTION":"BI","MASTER_ID":37663,"metacyc":"RXN-14840","compounds":"3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP","pmd":203.079}
{"X":7080,"KEGG":"R10597","RHEA_ID":38318,"DIRECTION":"BI","MASTER_ID":38315,"metacyc":"RXN-14940","compounds":"chorismate <=> 3-hydroxybenzoate + pyruvate","pmd":88.016}
{"X":7081,"KEGG":"R10598","RHEA_ID":30382,"DIRECTION":"BI","MASTER_ID":30379,"compounds":"(2E,6E)-farnesyl diphosphate <=> (+)-beta-chamigrene + diphosphate","pmd":177.943}
{"X":7082,"KEGG":"R10599","RHEA_ID":30378,"DIRECTION":"BI","MASTER_ID":30375,"compounds":"(2E,6E)-farnesyl diphosphate <=> (+)-thujopsene + diphosphate","pmd":177.943}
{"X":7083,"KEGG":"R10601","RHEA_ID":38938,"DIRECTION":"BI","MASTER_ID":38935,"metacyc":"R282-RXN","compounds":"cyclohexane-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> cyclohex-1-ene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein]","pmd":2.016}
{"X":7084,"KEGG":"R10602","RHEA_ID":39714,"DIRECTION":"BI","MASTER_ID":39711,"metacyc":"RXN-14991","compounds":"O2 + 2 reduced coenzyme F420-(gamma-Glu)(n) <=> 2 H(+) + 2 H2O + 2 oxidized coenzyme F420-(gamma-Glu)(n)","pmd":2.016}
{"X":7085,"KEGG":"R10603","RHEA_ID":42327,"DIRECTION":"BI","MASTER_ID":42324,"metacyc":"RXN-15038","compounds":"2 oxidized [2Fe-2S]-[ferredoxin] + reduced coenzyme F420-(gamma-Glu)(n) <=> 3 H(+) + oxidized coenzyme F420-(gamma-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin]","pmd":2.016}
{"X":7086,"KEGG":"R10604","RHEA_ID":59311,"DIRECTION":"BI","MASTER_ID":59308,"compounds":"D-galactono-1,5-lactone + H2O <=> D-galactonate + H(+)","pmd":18.011}
{"X":7087,"KEGG":"R10607","RHEA_ID":20875,"DIRECTION":"BI","MASTER_ID":20872,"compounds":"(20S)-ginsenoside Rd + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rb1 + H(+) + UDP","pmd":542.548}
{"X":7088,"KEGG":"R10607","RHEA_ID":20875,"DIRECTION":"BI","MASTER_ID":20872,"compounds":"(20S)-ginsenoside Rd + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rb1 + H(+) + UDP","pmd":162.053}
{"X":7089,"KEGG":"R10608","RHEA_ID":38622,"DIRECTION":"BI","MASTER_ID":38619,"compounds":"nicotinate beta-D-ribonucleotide + phenol <=> H(+) + nicotinate + phenyl 5-phospho-alpha-D-ribofuranoside","pmd":29.998}
{"X":7090,"KEGG":"R10609","RHEA_ID":22247,"DIRECTION":"BI","MASTER_ID":22244,"compounds":"kaempferol + UDP-alpha-D-xylose <=> H(+) + kaempferol 3-O-beta-D-xyloside + UDP","pmd":117.954}
{"X":7091,"KEGG":"R10610","RHEA_ID":48743,"DIRECTION":"BI","MASTER_ID":48740,"compounds":"[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + O-phospho-L-serine <=> [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + phosphate"}
{"X":7092,"KEGG":"R10611","RHEA_ID":36358,"DIRECTION":"BI","MASTER_ID":36355,"compounds":"4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine <=> 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine","pmd":101.048}
{"X":7093,"KEGG":"R10612","RHEA_ID":38294,"DIRECTION":"BI","MASTER_ID":38291,"compounds":"(S)-malyl-CoA + H2O <=> (S)-malate + CoA + H(+)","pmd":116.011}
{"X":7094,"KEGG":"R10613","RHEA_ID":36850,"DIRECTION":"BI","MASTER_ID":36847,"metacyc":"RXN-14461","compounds":"FAD + L-threonyl-[protein] <=> AMP + FMN-L-threonyl-[protein] + H(+)","pmd":438.094}
{"X":7095,"KEGG":"R10614","RHEA_ID":37886,"DIRECTION":"BI","MASTER_ID":37883,"ecocyc":"RXN0-7075","metacyc":"RXN0-7075","compounds":"acetyl-CoA + oxalate <=> acetate + oxalyl-CoA","pmd":29.974}
{"X":7096,"KEGG":"R10615","RHEA_ID":40166,"DIRECTION":"BI","MASTER_ID":40163,"metacyc":"RXN-15115","compounds":"D-glyceraldehyde + H2O + NADP(+) <=> (R)-glycerate + 2 H(+) + NADPH","pmd":638.057}
{"X":7097,"KEGG":"R10615","RHEA_ID":36782,"DIRECTION":"BI","MASTER_ID":36779,"metacyc":"RXN-8953","compounds":"2-oxoglutarate + GDP-alpha-D-perosamine <=> GDP-4-dehydro-alpha-D-rhamnose + L-glutamate","pmd":638.057}
{"X":7098,"KEGG":"R10616","RHEA_ID":46119,"DIRECTION":"BI","MASTER_ID":46116,"compounds":"2-dehydro-3-deoxy-D-galactonate <=> D-glyceraldehyde + pyruvate"}
{"X":7099,"KEGG":"R10620","RHEA_ID":37670,"DIRECTION":"BI","MASTER_ID":37667,"metacyc":"RXN-14841","compounds":"3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP","pmd":203.079}
{"X":7100,"KEGG":"R10621","RHEA_ID":54187,"DIRECTION":"BI","MASTER_ID":54184,"compounds":"an N-acyl-aromatic L-alpha-amino acid + H2O <=> a carboxylate + an aromatic L-alpha-amino acid"}
{"X":7101,"KEGG":"R10622","RHEA_ID":29318,"DIRECTION":"BI","MASTER_ID":29315,"compounds":"alpha-D-galactose 1-phosphate + H2O <=> D-galactose + phosphate","pmd":79.966}
{"X":7102,"KEGG":"R10623","RHEA_ID":38018,"DIRECTION":"BI","MASTER_ID":38015,"compounds":"delta-tocotrienol <=> 6-geranylgeranyl-2-methylbenzene-1,4-diol","pmd":0}
{"X":7103,"KEGG":"R10624","RHEA_ID":38026,"DIRECTION":"BI","MASTER_ID":38023,"compounds":"gamma-tocotrienol <=> 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol","pmd":0}
{"X":7104,"KEGG":"R10625","RHEA_ID":11275,"DIRECTION":"BI","MASTER_ID":11272,"compounds":"a (2R)-2-hydroxycarboxylate + a quinone <=> a 2-oxocarboxylate + a quinol"}
{"X":7105,"KEGG":"R10626","RHEA_ID":40534,"DIRECTION":"BI","MASTER_ID":40531,"compounds":"2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + neopikromycin + 2 oxidized [2Fe-2S]-[ferredoxin]","pmd":15.995}
{"X":7106,"KEGG":"R10627","RHEA_ID":40538,"DIRECTION":"BI","MASTER_ID":40535,"compounds":"4 H(+) + narbomycin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> 2 H2O + novapikromycin + 4 oxidized [2Fe-2S]-[ferredoxin]","pmd":31.99}
{"X":7107,"KEGG":"R10628","RHEA_ID":40550,"DIRECTION":"BI","MASTER_ID":40547,"compounds":"10-deoxymethymycin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> 2 H2O + novamethymycin + 4 oxidized [2Fe-2S]-[ferredoxin]","pmd":31.99}
{"X":7108,"KEGG":"R10629","RHEA_ID":38614,"DIRECTION":"BI","MASTER_ID":38611,"metacyc":"RXN-13872","compounds":"NAD(+) <=> cyclic ADP-ribose + H(+) + nicotinamide","pmd":123.056}
{"X":7109,"KEGG":"R10630","RHEA_ID":38618,"DIRECTION":"BI","MASTER_ID":38615,"metacyc":"RXN-13873","compounds":"cyclic ADP-ribose + H2O <=> ADP-D-ribose","pmd":18.011}
{"X":7110,"KEGG":"R10631","RHEA_ID":38606,"DIRECTION":"BI","MASTER_ID":38603,"compounds":"NADP(+) <=> 2'-phospho-cyclic ADP-ribose + nicotinamide","pmd":123.056}
{"X":7111,"KEGG":"R10632","RHEA_ID":38610,"DIRECTION":"BI","MASTER_ID":38607,"compounds":"2'-phospho-cyclic ADP-ribose + nicotinate <=> nicotinate-adenine dinucleotide phosphate","pmd":124.04}
{"X":7112,"KEGG":"R10632","RHEA_ID":38610,"DIRECTION":"BI","MASTER_ID":38607,"compounds":"2'-phospho-cyclic ADP-ribose + nicotinate <=> nicotinate-adenine dinucleotide phosphate","pmd":622.035}
{"X":7113,"KEGG":"R10638","RHEA_ID":55987,"DIRECTION":"BI","MASTER_ID":55984,"compounds":"(R)-mandelonitrile + UDP-alpha-D-glucose <=> (R)-prunasin + H(+) + UDP","pmd":162.053}
{"X":7114,"KEGG":"R10640","RHEA_ID":38282,"DIRECTION":"BI","MASTER_ID":38279,"metacyc":"RXN-8966","compounds":"(3R)-citramalate + succinyl-CoA <=> (3R)-citramalyl-CoA + succinate","pmd":30.01}
{"X":7115,"KEGG":"R10640","RHEA_ID":38282,"DIRECTION":"BI","MASTER_ID":38279,"metacyc":"RXN-8966","compounds":"(3R)-citramalate + succinyl-CoA <=> (3R)-citramalyl-CoA + succinate","pmd":30.011}
{"X":7116,"KEGG":"R10641","RHEA_ID":40658,"DIRECTION":"BI","MASTER_ID":40655,"metacyc":"RXN-14935","compounds":"(R)-malate + succinyl-CoA <=> (R)-malyl-CoA + succinate","pmd":15.995}
{"X":7117,"KEGG":"R10645","RHEA_ID":37078,"DIRECTION":"BI","MASTER_ID":37075,"compounds":"[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine <=> 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7118,"KEGG":"R10645","RHEA_ID":37070,"DIRECTION":"BI","MASTER_ID":37067,"compounds":"[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine <=> 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7119,"KEGG":"R10646","RHEA_ID":36342,"DIRECTION":"BI","MASTER_ID":36339,"compounds":"[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine <=> 2-sulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine","pmd":147.035}
{"X":7120,"KEGG":"R10646","RHEA_ID":37074,"DIRECTION":"BI","MASTER_ID":37071,"compounds":"[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine <=> 2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine","pmd":147.035}
{"X":7121,"KEGG":"R10647","RHEA_ID":37082,"DIRECTION":"BI","MASTER_ID":37079,"compounds":"2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine <=> 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7122,"KEGG":"R10647","RHEA_ID":37066,"DIRECTION":"BI","MASTER_ID":37063,"compounds":"2-sulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine <=> 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7123,"KEGG":"R10652","RHEA_ID":37090,"DIRECTION":"BI","MASTER_ID":37087,"compounds":"[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine <=> 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7124,"KEGG":"R10653","RHEA_ID":37086,"DIRECTION":"BI","MASTER_ID":37083,"compounds":"[sulfur carrier]-SH + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + S-adenosyl-L-methionine <=> [sulfur carrier]-H + H(+) + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-homocysteine","pmd":147.035}
{"X":7125,"KEGG":"R10654","RHEA_ID":36354,"DIRECTION":"BI","MASTER_ID":36351,"compounds":"AH2 + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-methionine <=> 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + A + H(+) + L-methionine","pmd":14.016}
{"X":7126,"KEGG":"R10655","RHEA_ID":40230,"DIRECTION":"BI","MASTER_ID":40227,"metacyc":"RXN-14843","compounds":"3'-phosphoadenylyl sulfate + desulfo-A47934 <=> A47934 + adenosine 3',5'-bisphosphate + H(+)","pmd":79.957}
{"X":7127,"KEGG":"R10656","RHEA_ID":24527,"DIRECTION":"BI","MASTER_ID":24524,"compounds":"20-oxo-5-O-beta-D-mycaminosyltylonolide + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 5-O-beta-D-mycaminosyltylonolide + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]","pmd":15.995}
{"X":7128,"KEGG":"R10657","RHEA_ID":40374,"DIRECTION":"BI","MASTER_ID":40371,"compounds":"alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-di-trans,octa-cis-undecaprenol + ATP <=> 3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-di-trans,octa-cis-undecaprenol + ADP + H(+)","pmd":79.966}
{"X":7129,"KEGG":"R10658","RHEA_ID":36642,"DIRECTION":"BI","MASTER_ID":36639,"compounds":"3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-di-trans,octa-cis-undecaprenol + S-adenosyl-L-methionine <=> 3-O-methylphospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenol + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7130,"KEGG":"R10659","RHEA_ID":38058,"DIRECTION":"BI","MASTER_ID":38055,"compounds":"CTP + phytol <=> CDP + H(+) + phytyl phosphate","pmd":79.966}
{"X":7131,"KEGG":"R10660","RHEA_ID":40238,"DIRECTION":"BI","MASTER_ID":40235,"metacyc":"RXN-15295","compounds":"coenzyme B + coenzyme M + fumarate <=> coenzyme M-coenzyme B heterodisulfide + succinate","pmd":23.949}
{"X":7132,"KEGG":"R10660","RHEA_ID":40238,"DIRECTION":"BI","MASTER_ID":40235,"metacyc":"RXN-15295","compounds":"coenzyme B + coenzyme M + fumarate <=> coenzyme M-coenzyme B heterodisulfide + succinate","pmd":2.016}
{"X":7133,"KEGG":"R10660","RHEA_ID":40238,"DIRECTION":"BI","MASTER_ID":40235,"metacyc":"RXN-15295","compounds":"coenzyme B + coenzyme M + fumarate <=> coenzyme M-coenzyme B heterodisulfide + succinate","pmd":139.96}
{"X":7134,"KEGG":"R10662","RHEA_ID":40562,"DIRECTION":"BI","MASTER_ID":40559,"compounds":"dTDP-beta-L-evernosamine + NADPH + O2 <=> dTDP-N-hydroxy-beta-L-evernosamine + H2O + NADP(+)","pmd":169.963}
{"X":7135,"KEGG":"R10662","RHEA_ID":40562,"DIRECTION":"BI","MASTER_ID":40559,"compounds":"dTDP-beta-L-evernosamine + NADPH + O2 <=> dTDP-N-hydroxy-beta-L-evernosamine + H2O + NADP(+)","pmd":15.995}
{"X":7136,"KEGG":"R10663","RHEA_ID":40566,"DIRECTION":"BI","MASTER_ID":40563,"compounds":"dTDP-N-hydroxy-beta-L-evernosamine + H(+) + NADPH + O2 <=> dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 2 H2O + NADP(+)","pmd":171.979}
{"X":7137,"KEGG":"R10663","RHEA_ID":40566,"DIRECTION":"BI","MASTER_ID":40563,"compounds":"dTDP-N-hydroxy-beta-L-evernosamine + H(+) + NADPH + O2 <=> dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 2 H2O + NADP(+)","pmd":2.016}
{"X":7138,"KEGG":"R10664","RHEA_ID":40558,"DIRECTION":"BI","MASTER_ID":40555,"compounds":"dTDP-beta-L-evernosamine + H(+) + 2 NADPH + 2 O2 <=> dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 3 H2O + 2 NADP(+)","pmd":171.979}
{"X":7139,"KEGG":"R10664","RHEA_ID":40558,"DIRECTION":"BI","MASTER_ID":40555,"compounds":"dTDP-beta-L-evernosamine + H(+) + 2 NADPH + 2 O2 <=> dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 3 H2O + 2 NADP(+)","pmd":13.979}
{"X":7140,"KEGG":"R10665","RHEA_ID":30838,"DIRECTION":"BI","MASTER_ID":30835,"metacyc":"RXN-14994","compounds":"H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose <=> NADP(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose","pmd":2.016}
{"X":7141,"KEGG":"R10665","RHEA_ID":30838,"DIRECTION":"BI","MASTER_ID":30835,"metacyc":"RXN-14994","compounds":"H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose <=> NADP(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose","pmd":155.012}
{"X":7142,"KEGG":"R10666","RHEA_ID":40054,"DIRECTION":"BI","MASTER_ID":40051,"compounds":"chorismate <=> 3-[(1-carboxyvinyl)-oxy]benzoate + H2O","pmd":18.01}
{"X":7143,"KEGG":"R10667","RHEA_ID":33078,"DIRECTION":"BI","MASTER_ID":33075,"compounds":"3-[(1-carboxyvinyl)-oxy]benzoate + H2O + S-adenosyl-L-methionine <=> 6-amino-6-deoxyfutalosine + H(+) + hydrogencarbonate + L-methionine","pmd":14.996}
{"X":7144,"KEGG":"R10667","RHEA_ID":33078,"DIRECTION":"BI","MASTER_ID":33075,"compounds":"3-[(1-carboxyvinyl)-oxy]benzoate + H2O + S-adenosyl-L-methionine <=> 6-amino-6-deoxyfutalosine + H(+) + hydrogencarbonate + L-methionine","pmd":58.986}
{"X":7145,"KEGG":"R10668","RHEA_ID":33082,"DIRECTION":"BI","MASTER_ID":33079,"compounds":"6-amino-6-deoxyfutalosine + H2O <=> adenine + dehypoxanthine futalosine","pmd":117.044}
{"X":7146,"KEGG":"R10671","RHEA_ID":32314,"DIRECTION":"BI","MASTER_ID":32311,"compounds":"L-tyrosine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-4-hydroxyphenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]","pmd":30.011}
{"X":7147,"KEGG":"R10673","RHEA_ID":26316,"DIRECTION":"BI","MASTER_ID":26313,"compounds":"2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate <=> dihydroxyacetone phosphate + L-aspartate 4-semialdehyde","pmd":117.043}
{"X":7148,"KEGG":"R10674","RHEA_ID":38278,"DIRECTION":"BI","MASTER_ID":38275,"metacyc":"RXN-13231","compounds":"(3R)-citramalyl-CoA <=> acetyl-CoA + pyruvate","pmd":88.016}
{"X":7149,"KEGG":"R10676","RHEA_ID":30842,"DIRECTION":"BI","MASTER_ID":30839,"compounds":"UDP-2-acetamido-2,6-dideoxy-beta-L-talose <=> UDP-N-acetyl-beta-L-fucosamine","pmd":0}
{"X":7150,"KEGG":"R10677","RHEA_ID":40046,"DIRECTION":"BI","MASTER_ID":40043,"compounds":"ATP + citrate + L-glutamate <=> ADP + beta-citrylglutamate + H(+) + phosphate","pmd":174.016}
{"X":7151,"KEGG":"R10677","RHEA_ID":40046,"DIRECTION":"BI","MASTER_ID":40043,"compounds":"ATP + citrate + L-glutamate <=> ADP + beta-citrylglutamate + H(+) + phosphate","pmd":129.043}
{"X":7152,"KEGG":"R10677","RHEA_ID":40046,"DIRECTION":"BI","MASTER_ID":40043,"compounds":"ATP + citrate + L-glutamate <=> ADP + beta-citrylglutamate + H(+) + phosphate","pmd":79.966}
{"X":7153,"KEGG":"R10678","RHEA_ID":40038,"DIRECTION":"BI","MASTER_ID":40035,"compounds":"ATP + L-glutamate + N-acetyl-L-aspartate <=> ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate + phosphate","pmd":129.043}
{"X":7154,"KEGG":"R10678","RHEA_ID":40038,"DIRECTION":"BI","MASTER_ID":40035,"compounds":"ATP + L-glutamate + N-acetyl-L-aspartate <=> ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate + phosphate","pmd":157.038}
{"X":7155,"KEGG":"R10678","RHEA_ID":40038,"DIRECTION":"BI","MASTER_ID":40035,"compounds":"ATP + L-glutamate + N-acetyl-L-aspartate <=> ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate + phosphate","pmd":79.966}
{"X":7156,"KEGG":"R10679","RHEA_ID":40042,"DIRECTION":"BI","MASTER_ID":40039,"compounds":"2 ATP + 2 L-glutamate + N-acetyl-L-aspartate <=> 2 ADP + 2 H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate + 2 phosphate","pmd":73.862}
{"X":7157,"KEGG":"R10679","RHEA_ID":40042,"DIRECTION":"BI","MASTER_ID":40039,"compounds":"2 ATP + 2 L-glutamate + N-acetyl-L-aspartate <=> 2 ADP + 2 H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate + 2 phosphate","pmd":251.981}
{"X":7158,"KEGG":"R10679","RHEA_ID":40042,"DIRECTION":"BI","MASTER_ID":40039,"compounds":"2 ATP + 2 L-glutamate + N-acetyl-L-aspartate <=> 2 ADP + 2 H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate + 2 phosphate","pmd":279.976}
{"X":7159,"KEGG":"R10680","RHEA_ID":39982,"DIRECTION":"BI","MASTER_ID":39979,"compounds":"(+-)-pavine + S-adenosyl-L-methionine <=> H(+) + N-methylpavine + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7160,"KEGG":"R10681","RHEA_ID":37662,"DIRECTION":"BI","MASTER_ID":37659,"metacyc":"RXN-14835","compounds":"anthraniloyl-CoA + methanol <=> CoA + O-methyl anthranilate","pmd":119.037}
{"X":7161,"KEGG":"R10685","RHEA_ID":55711,"DIRECTION":"BI","MASTER_ID":55708,"compounds":"[ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) <=> [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 2 H(+) + 3 H2O + nicotinamide","pmd":68.068}
{"X":7162,"KEGG":"R10695","RHEA_ID":40078,"DIRECTION":"BI","MASTER_ID":40075,"compounds":"6-amino-6-deoxyfutalosine + H(+) + H2O <=> futalosine + NH4(+)","pmd":0.984}
{"X":7163,"KEGG":"R10696","RHEA_ID":40066,"DIRECTION":"BI","MASTER_ID":40063,"metacyc":"RXN-15012","compounds":"6-oxocyclohex-1-ene-1-carbonyl-CoA + H2O <=> 2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA","pmd":18.011}
{"X":7164,"KEGG":"R10698","RHEA_ID":37554,"DIRECTION":"BI","MASTER_ID":37551,"metacyc":"RXN8J2-137","compounds":"3-dehydro-D-glucose 6-phosphate + L-glutamate <=> 2-oxoglutarate + D-kanosamine 6-phosphate","pmd":1.032}
{"X":7165,"KEGG":"R10699","RHEA_ID":26332,"DIRECTION":"BI","MASTER_ID":26329,"metacyc":"RXN-14930","compounds":"8-amino-7-oxononanoate + L-lysine <=> (S)-2-amino-6-oxohexanoate + 7,8-diaminononanoate","pmd":1.032}
{"X":7166,"KEGG":"R10702","RHEA_ID":49995,"DIRECTION":"BI","MASTER_ID":49992,"compounds":"H(+) + NADH + O2 + propane <=> H2O + NAD(+) + propan-2-ol"}
{"X":7167,"KEGG":"R10703","RHEA_ID":41987,"DIRECTION":"BI","MASTER_ID":41984,"metacyc":"RXN-17571","compounds":"NAD(+) + propan-2-ol <=> acetone + H(+) + NADH"}
{"X":7168,"KEGG":"R10704","RHEA_ID":49991,"DIRECTION":"BI","MASTER_ID":49988,"compounds":"acetone + H(+) + NADPH + O2 <=> H2O + methyl acetate + NADP(+)"}
{"X":7169,"KEGG":"R10705","RHEA_ID":60443,"DIRECTION":"BI","MASTER_ID":60440,"compounds":"H2O + methyl acetate <=> acetate + H(+) + methanol"}
{"X":7170,"KEGG":"R10706","RHEA_ID":16336,"DIRECTION":"BI","MASTER_ID":16333,"compounds":"2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[citrate lyase ACP] <=> diphosphate + holo-[citrate lyase ACP]"}
{"X":7171,"KEGG":"R10706","RHEA_ID":42647,"DIRECTION":"BI","MASTER_ID":42644,"compounds":"2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[malonate decarboxylase ACP] <=> diphosphate + holo-[malonate decarboxylase ACP]"}
{"X":7172,"KEGG":"R10707","RHEA_ID":12083,"DIRECTION":"BI","MASTER_ID":12080,"compounds":"acetyl-CoA + H(+) + malonyl-[ACP] <=> 3-oxobutanoyl-[ACP] + CO2 + CoA","pmd":42.011}
{"X":7173,"KEGG":"R10708","RHEA_ID":38006,"DIRECTION":"BI","MASTER_ID":38003,"compounds":"all-trans-geranylgeranyl diphosphate + H(+) + homogentisate <=> 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2 + diphosphate","pmd":53.891}
{"X":7174,"KEGG":"R10708","RHEA_ID":38006,"DIRECTION":"BI","MASTER_ID":38003,"compounds":"all-trans-geranylgeranyl diphosphate + H(+) + homogentisate <=> 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2 + diphosphate","pmd":228.26}
{"X":7175,"KEGG":"R10709","RHEA_ID":38002,"DIRECTION":"BI","MASTER_ID":37999,"compounds":"2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + S-adenosyl-L-methionine <=> H(+) + plastoquinol-9 + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7176,"KEGG":"R10710","RHEA_ID":38010,"DIRECTION":"BI","MASTER_ID":38007,"compounds":"6-geranylgeranyl-2-methylbenzene-1,4-diol + S-adenosyl-L-methionine <=> 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine","pmd":12.181}
{"X":7177,"KEGG":"R10712","RHEA_ID":47851,"DIRECTION":"BI","MASTER_ID":47848,"compounds":"2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) <=> CO2 + diphosphate + thiamine phosphate","pmd":78.082}
{"X":7178,"KEGG":"R10712","RHEA_ID":47851,"DIRECTION":"BI","MASTER_ID":47848,"compounds":"2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) <=> CO2 + diphosphate + thiamine phosphate","pmd":46.071}
{"X":7179,"KEGG":"R10713","RHEA_ID":51007,"DIRECTION":"BI","MASTER_ID":51004,"metacyc":"RXN-11332","compounds":"2 [Fe(III)cytochrome cL] + a primary alcohol <=> 2 [Fe(II)cytochrome cL] + an aldehyde + 2 H(+)"}
{"X":7180,"KEGG":"R10716","RHEA_ID":42787,"DIRECTION":"BI","MASTER_ID":42784,"compounds":"adenosine(2085) in 23S rRNA + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(6)-dimethyladenosine(2085) in 23S rRNA + 2 S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7181,"KEGG":"R10718","RHEA_ID":35618,"DIRECTION":"BI","MASTER_ID":35615,"compounds":"hydroxyacetone + NAD(+) <=> H(+) + methylglyoxal + NADH"}
{"X":7182,"KEGG":"R10719","RHEA_ID":40514,"DIRECTION":"BI","MASTER_ID":40511,"compounds":"2,3-dihydroxypropane-1-sulfonate + NAD(+) <=> 3-sulfolactaldehyde + H(+) + NADH","pmd":2.016}
{"X":7183,"KEGG":"R10719","RHEA_ID":40514,"DIRECTION":"BI","MASTER_ID":40511,"compounds":"2,3-dihydroxypropane-1-sulfonate + NAD(+) <=> 3-sulfolactaldehyde + H(+) + NADH","pmd":510.123}
{"X":7184,"KEGG":"R10720","RHEA_ID":41423,"DIRECTION":"BI","MASTER_ID":41420,"metacyc":"RXN-15414","compounds":"2 3-amino-4-hydroxybenzoate + H(+) + N-acetyl-L-cysteine + 2 O2 <=> CO2 + grixazone B + 4 H2O","pmd":254.033}
{"X":7185,"KEGG":"R10720","RHEA_ID":41423,"DIRECTION":"BI","MASTER_ID":41420,"metacyc":"RXN-15414","compounds":"2 3-amino-4-hydroxybenzoate + H(+) + N-acetyl-L-cysteine + 2 O2 <=> CO2 + grixazone B + 4 H2O","pmd":264.021}
{"X":7186,"KEGG":"R10721","RHEA_ID":41435,"DIRECTION":"BI","MASTER_ID":41432,"metacyc":"RXN-15302","compounds":"3-methyl-L-tyrosine + H2O2 <=> 5-hydroxy-3-methyl-L-tyrosine + H2O","pmd":15.995}
{"X":7187,"KEGG":"R10722","RHEA_ID":41447,"DIRECTION":"BI","MASTER_ID":41444,"compounds":"(2R)-(2-amino-1-hydroxyethyl)phosphonate + O2 <=> glycine + 2 H(+) + phosphate"}
{"X":7188,"KEGG":"R10723","RHEA_ID":41451,"DIRECTION":"BI","MASTER_ID":41448,"compounds":"2-oxoglutarate + L-isoleucine + O2 <=> (4S)-4-hydroxy-L-isoleucine + CO2 + succinate","pmd":1.068}
{"X":7189,"KEGG":"R10723","RHEA_ID":41451,"DIRECTION":"BI","MASTER_ID":41448,"compounds":"2-oxoglutarate + L-isoleucine + O2 <=> (4S)-4-hydroxy-L-isoleucine + CO2 + succinate","pmd":13.068}
{"X":7190,"KEGG":"R10724","RHEA_ID":41443,"DIRECTION":"BI","MASTER_ID":41440,"compounds":"(2-aminoethyl)phosphonate + 2-oxoglutarate + O2 <=> (2R)-(2-amino-1-hydroxyethyl)phosphonate + CO2 + succinate","pmd":5.002}
{"X":7191,"KEGG":"R10724","RHEA_ID":41443,"DIRECTION":"BI","MASTER_ID":41440,"compounds":"(2-aminoethyl)phosphonate + 2-oxoglutarate + O2 <=> (2R)-(2-amino-1-hydroxyethyl)phosphonate + CO2 + succinate","pmd":6.998}
{"X":7192,"KEGG":"R10725","RHEA_ID":41455,"DIRECTION":"BI","MASTER_ID":41452,"metacyc":"RXN-15303","compounds":"5-methyl-1-naphthoate + H(+) + NADPH + O2 <=> 3-hydroxy-5-methyl-1-naphthoate + H2O + NADP(+)","pmd":15.995}
{"X":7193,"KEGG":"R10725","RHEA_ID":41455,"DIRECTION":"BI","MASTER_ID":41452,"metacyc":"RXN-15303","compounds":"5-methyl-1-naphthoate + H(+) + NADPH + O2 <=> 3-hydroxy-5-methyl-1-naphthoate + H2O + NADP(+)","pmd":543.028}
{"X":7194,"KEGG":"R10726","RHEA_ID":31442,"DIRECTION":"BI","MASTER_ID":31439,"compounds":"(2E,6E)-farnesyl diphosphate <=> alpha-longipinene + diphosphate","pmd":177.943}
{"X":7195,"KEGG":"R10728","RHEA_ID":41519,"DIRECTION":"BI","MASTER_ID":41516,"metacyc":"RXN-15395","compounds":"O2 + phylloquinone + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + omega-hydroxyphylloquinone + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":7196,"KEGG":"R10729","RHEA_ID":41535,"DIRECTION":"BI","MASTER_ID":41532,"compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 <=> (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 3-hydroxy-L-phenylalanine","pmd":15.995}
{"X":7197,"KEGG":"R10730","RHEA_ID":41407,"DIRECTION":"BI","MASTER_ID":41404,"compounds":"(R)-2-methylpyrrolidine + NADP(+) <=> 2-methyl-1-pyrroline + H(+) + NADPH"}
{"X":7198,"KEGG":"R10732","RHEA_ID":31430,"DIRECTION":"BI","MASTER_ID":31427,"compounds":"(2E,6E)-farnesyl diphosphate <=> (-)-exo-alpha-bergamotene + diphosphate","pmd":177.943}
{"X":7199,"KEGG":"R10733","RHEA_ID":31438,"DIRECTION":"BI","MASTER_ID":31435,"compounds":"(2E,6E)-farnesyl diphosphate <=> (+)-alpha-santalene + diphosphate","pmd":177.943}
{"X":7200,"KEGG":"R10734","RHEA_ID":31434,"DIRECTION":"BI","MASTER_ID":31431,"compounds":"(2E,6E)-farnesyl diphosphate <=> (-)-beta-santalene + diphosphate","pmd":177.943}
{"X":7201,"KEGG":"R10758","RHEA_ID":58899,"DIRECTION":"BI","MASTER_ID":58896,"compounds":"4-hydroxybutanoate + ATP + CoA <=> 4-hydroxybutanoyl-CoA + ADP + phosphate","pmd":322.982}
{"X":7202,"KEGG":"R10758","RHEA_ID":58899,"DIRECTION":"BI","MASTER_ID":58896,"compounds":"4-hydroxybutanoate + ATP + CoA <=> 4-hydroxybutanoyl-CoA + ADP + phosphate","pmd":86.037}
{"X":7203,"KEGG":"R10758","RHEA_ID":58899,"DIRECTION":"BI","MASTER_ID":58896,"compounds":"4-hydroxybutanoate + ATP + CoA <=> 4-hydroxybutanoyl-CoA + ADP + phosphate","pmd":79.966}
{"X":7204,"KEGG":"R10761","RHEA_ID":55559,"DIRECTION":"BI","MASTER_ID":55556,"metacyc":"RXN-14946","compounds":"a hydroperoxyeicosatetraenoate <=> an oxoeicosatetraenoate + H2O"}
{"X":7205,"KEGG":"R10762","RHEA_ID":41555,"DIRECTION":"BI","MASTER_ID":41552,"metacyc":"RXN-15427","compounds":"(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O <=> diphosphate + ophiobolin F","pmd":159.933}
{"X":7206,"KEGG":"R10763","RHEA_ID":41631,"DIRECTION":"BI","MASTER_ID":41628,"compounds":"geranylgeranyl diphosphate + H2O <=> cyclooctat-9-en-7-ol + diphosphate","pmd":159.933}
{"X":7207,"KEGG":"R10766","RHEA_ID":55563,"DIRECTION":"BI","MASTER_ID":55560,"metacyc":"RXN-14947","compounds":"a hydroperoxyeicosatetraenoate <=> a hydroxy epoxy eicosatetraenoate"}
{"X":7208,"KEGG":"R10767","RHEA_ID":42099,"DIRECTION":"BI","MASTER_ID":42096,"compounds":"ATP + carbamoyl phosphate + H2O + tobramycin <=> AMP + diphosphate + H(+) + nebramycin 5' + phosphate","pmd":3.269}
{"X":7209,"KEGG":"R10767","RHEA_ID":42099,"DIRECTION":"BI","MASTER_ID":42096,"compounds":"ATP + carbamoyl phosphate + H2O + tobramycin <=> AMP + diphosphate + H(+) + nebramycin 5' + phosphate","pmd":43.006}
{"X":7210,"KEGG":"R10767","RHEA_ID":42099,"DIRECTION":"BI","MASTER_ID":42096,"compounds":"ATP + carbamoyl phosphate + H2O + tobramycin <=> AMP + diphosphate + H(+) + nebramycin 5' + phosphate","pmd":206.08}
{"X":7211,"KEGG":"R10767","RHEA_ID":42103,"DIRECTION":"BI","MASTER_ID":42100,"compounds":"ATP + carbamoyl phosphate + H2O + kanamycin A <=> 6''-O-carbamoylkanamycin A + AMP + diphosphate + H(+) + phosphate","pmd":3.269}
{"X":7212,"KEGG":"R10767","RHEA_ID":42103,"DIRECTION":"BI","MASTER_ID":42100,"compounds":"ATP + carbamoyl phosphate + H2O + kanamycin A <=> 6''-O-carbamoylkanamycin A + AMP + diphosphate + H(+) + phosphate","pmd":43.006}
{"X":7213,"KEGG":"R10767","RHEA_ID":42103,"DIRECTION":"BI","MASTER_ID":42100,"compounds":"ATP + carbamoyl phosphate + H2O + kanamycin A <=> 6''-O-carbamoylkanamycin A + AMP + diphosphate + H(+) + phosphate","pmd":206.08}
{"X":7214,"KEGG":"R10769","RHEA_ID":41643,"DIRECTION":"BI","MASTER_ID":41640,"compounds":"3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA <=> 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate","pmd":220.11}
{"X":7215,"KEGG":"R10769","RHEA_ID":41643,"DIRECTION":"BI","MASTER_ID":41640,"compounds":"3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA <=> 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate","pmd":108.943}
{"X":7216,"KEGG":"R10769","RHEA_ID":41643,"DIRECTION":"BI","MASTER_ID":41640,"compounds":"3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA <=> 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate","pmd":159.933}
{"X":7217,"KEGG":"R10770","RHEA_ID":29294,"DIRECTION":"BI","MASTER_ID":29291,"compounds":"(25S)-3-oxocholest-4-en-26-oate + ATP + CoA <=> (25S)-3-oxocholest-4-en-26-oyl-CoA + AMP + diphosphate","pmd":159.933}
{"X":7218,"KEGG":"R10770","RHEA_ID":29294,"DIRECTION":"BI","MASTER_ID":29291,"compounds":"(25S)-3-oxocholest-4-en-26-oate + ATP + CoA <=> (25S)-3-oxocholest-4-en-26-oyl-CoA + AMP + diphosphate","pmd":67.25}
{"X":7219,"KEGG":"R10770","RHEA_ID":29294,"DIRECTION":"BI","MASTER_ID":29291,"compounds":"(25S)-3-oxocholest-4-en-26-oate + ATP + CoA <=> (25S)-3-oxocholest-4-en-26-oyl-CoA + AMP + diphosphate","pmd":420.052}
{"X":7220,"KEGG":"R10771","RHEA_ID":41647,"DIRECTION":"BI","MASTER_ID":41644,"compounds":"2-hydroxy-7-methoxy-5-methyl-1-naphthoate + ATP + CoA <=> 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA + AMP + diphosphate","pmd":159.933}
{"X":7221,"KEGG":"R10771","RHEA_ID":41647,"DIRECTION":"BI","MASTER_ID":41644,"compounds":"2-hydroxy-7-methoxy-5-methyl-1-naphthoate + ATP + CoA <=> 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA + AMP + diphosphate","pmd":114.99}
{"X":7222,"KEGG":"R10771","RHEA_ID":41647,"DIRECTION":"BI","MASTER_ID":41644,"compounds":"2-hydroxy-7-methoxy-5-methyl-1-naphthoate + ATP + CoA <=> 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA + AMP + diphosphate","pmd":214.063}
{"X":7223,"KEGG":"R10773","RHEA_ID":49539,"DIRECTION":"BI","MASTER_ID":49536,"compounds":"2-amino-2-deoxy-D-gluconate <=> (2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate + H2O","pmd":18.011}
{"X":7224,"KEGG":"R10774","RHEA_ID":49543,"DIRECTION":"BI","MASTER_ID":49540,"compounds":"(2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate <=> (4S,5R)-4,5,6-trihydroxy-2-iminohexanoate","pmd":0}
{"X":7225,"KEGG":"R10775","RHEA_ID":49547,"DIRECTION":"BI","MASTER_ID":49544,"compounds":"(4S,5R)-4,5,6-trihydroxy-2-iminohexanoate + H2O <=> 2-dehydro-3-deoxy-D-gluconate + NH4(+)","pmd":0.984}
{"X":7226,"KEGG":"R10776","RHEA_ID":36170,"DIRECTION":"BI","MASTER_ID":36167,"compounds":"a 2'-deoxyribonucleoside 5'-phosphate + H2O <=> a 2'-deoxyribonucleoside + phosphate"}
{"X":7227,"KEGG":"R10779","RHEA_ID":42887,"DIRECTION":"BI","MASTER_ID":42884,"compounds":"(R)-mevalonate + ATP <=> (R)-3-phosphomevalonate + ADP + H(+)","pmd":79.966}
{"X":7228,"KEGG":"R10780","RHEA_ID":42891,"DIRECTION":"BI","MASTER_ID":42888,"compounds":"(R)-3-phosphomevalonate + ATP <=> (R)-3,5-bisphosphomevalonate + ADP + H(+)","pmd":79.966}
{"X":7229,"KEGG":"R10781","RHEA_ID":56503,"DIRECTION":"BI","MASTER_ID":56500,"compounds":"(R)-3,5-bisphosphomevalonate + H(+) <=> CO2 + isopentenyl phosphate + phosphate","pmd":141.967}
{"X":7230,"KEGG":"R10782","RHEA_ID":26533,"DIRECTION":"BI","MASTER_ID":26530,"metacyc":"RXN-8890","compounds":"4-hydroxybutanoyl-CoA <=> (2E)-butenoyl-CoA + H2O","pmd":18.011}
{"X":7231,"KEGG":"R10785","RHEA_ID":42663,"DIRECTION":"BI","MASTER_ID":42660,"metacyc":"RXN-15615","compounds":"NAD(+) + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + NADH + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose","pmd":59.051}
{"X":7232,"KEGG":"R10785","RHEA_ID":42663,"DIRECTION":"BI","MASTER_ID":42660,"metacyc":"RXN-15615","compounds":"NAD(+) + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + NADH + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose","pmd":2.016}
{"X":7233,"KEGG":"R10786","RHEA_ID":42771,"DIRECTION":"BI","MASTER_ID":42768,"metacyc":"RXN-15632","compounds":"a (2S)-2-hydroxycarboxylate + NADP(+) <=> a 2-oxocarboxylate + H(+) + NADPH"}
{"X":7234,"KEGG":"R10787","RHEA_ID":42667,"DIRECTION":"BI","MASTER_ID":42664,"compounds":"L-arabinofuranose + NADP(+) <=> H(+) + L-arabinono-1,4-lactone + NADPH","pmd":2.016}
{"X":7235,"KEGG":"R10787","RHEA_ID":42667,"DIRECTION":"BI","MASTER_ID":42664,"compounds":"L-arabinofuranose + NADP(+) <=> H(+) + L-arabinono-1,4-lactone + NADPH","pmd":596.046}
{"X":7236,"KEGG":"R10788","RHEA_ID":42671,"DIRECTION":"BI","MASTER_ID":42668,"metacyc":"RXN-15753","compounds":"L-rhamnofuranose + NADP(+) <=> H(+) + L-rhamnono-1,4-lactone + NADPH","pmd":2.016}
{"X":7237,"KEGG":"R10788","RHEA_ID":42671,"DIRECTION":"BI","MASTER_ID":42668,"metacyc":"RXN-15753","compounds":"L-rhamnofuranose + NADP(+) <=> H(+) + L-rhamnono-1,4-lactone + NADPH","pmd":582.031}
{"X":7238,"KEGG":"R10789","RHEA_ID":41511,"DIRECTION":"BI","MASTER_ID":41508,"compounds":"L-ornithine + NADPH + O2 <=> H2O + N(5)-hydroxy-L-ornithine + NADP(+)","pmd":597.006}
{"X":7239,"KEGG":"R10789","RHEA_ID":41511,"DIRECTION":"BI","MASTER_ID":41508,"compounds":"L-ornithine + NADPH + O2 <=> H2O + N(5)-hydroxy-L-ornithine + NADP(+)","pmd":15.995}
{"X":7240,"KEGG":"R10790","RHEA_ID":41515,"DIRECTION":"BI","MASTER_ID":41512,"compounds":"L-ornithine + NADH + O2 <=> H2O + N(5)-hydroxy-L-ornithine + NAD(+)","pmd":15.995}
{"X":7241,"KEGG":"R10790","RHEA_ID":41515,"DIRECTION":"BI","MASTER_ID":41512,"compounds":"L-ornithine + NADH + O2 <=> H2O + N(5)-hydroxy-L-ornithine + NAD(+)","pmd":517.04}
{"X":7242,"KEGG":"R10791","RHEA_ID":12207,"DIRECTION":"BI","MASTER_ID":12204,"compounds":"dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] <=> 3alpha-hydroxy-3,5-dihydromonacolin L carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":7243,"KEGG":"R10792","RHEA_ID":24335,"DIRECTION":"BI","MASTER_ID":24332,"compounds":"3alpha-hydroxy-3,5-dihydromonacolin L carboxylate <=> H2O + monacolin L carboxylate","pmd":18.011}
{"X":7244,"KEGG":"R10793","RHEA_ID":42371,"DIRECTION":"BI","MASTER_ID":42368,"compounds":"dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + monacolin L carboxylate + oxidized [NADPH--hemoprotein reductase]","pmd":2.016}
{"X":7245,"KEGG":"R10794","RHEA_ID":29602,"DIRECTION":"BI","MASTER_ID":29599,"compounds":"monacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + monacolin J carboxylate + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":7246,"KEGG":"R10795","RHEA_ID":40158,"DIRECTION":"BI","MASTER_ID":40155,"metacyc":"RXN-15675","compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":7247,"KEGG":"R10796","RHEA_ID":42831,"DIRECTION":"BI","MASTER_ID":42828,"compounds":"2-hydroxy-5-methyl-1-naphthoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2,7-dihydroxy-5-methyl-1-naphthoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]","pmd":15.995}
{"X":7248,"KEGG":"R10797","RHEA_ID":42767,"DIRECTION":"BI","MASTER_ID":42764,"compounds":"formate + 2 H(+) + oxidized coenzyme F420-(gamma-Glu)(n) <=> CO2 + reduced coenzyme F420-(gamma-Glu)(n)","pmd":2.016}
{"X":7249,"KEGG":"R10798","RHEA_ID":41663,"DIRECTION":"BI","MASTER_ID":41660,"compounds":"dihydrosanguinarine + NAD(+) <=> NADH + sanguinarine","pmd":332.025}
{"X":7250,"KEGG":"R10799","RHEA_ID":41659,"DIRECTION":"BI","MASTER_ID":41656,"compounds":"dihydrosanguinarine + NADP(+) <=> NADPH + sanguinarine","pmd":411.991}
{"X":7251,"KEGG":"R10800","RHEA_ID":41667,"DIRECTION":"BI","MASTER_ID":41664,"compounds":"dihydrochelirubine + NAD(+) <=> chelirubine + NADH","pmd":302.014}
{"X":7252,"KEGG":"R10801","RHEA_ID":41671,"DIRECTION":"BI","MASTER_ID":41668,"compounds":"dihydrochelirubine + NADP(+) <=> chelirubine + NADPH","pmd":381.981}
{"X":7253,"KEGG":"R10801","RHEA_ID":41671,"DIRECTION":"BI","MASTER_ID":41668,"compounds":"dihydrochelirubine + NADP(+) <=> chelirubine + NADPH","pmd":381.98}
{"X":7254,"KEGG":"R10802","RHEA_ID":42807,"DIRECTION":"BI","MASTER_ID":42804,"compounds":"5,6,7,8-tetrahydromethanopterin + A <=> 7,8-dihydromethanopterin + AH2","pmd":2.016}
{"X":7255,"KEGG":"R10803","RHEA_ID":42811,"DIRECTION":"BI","MASTER_ID":42808,"metacyc":"RXN-15618","compounds":"2 H(+) + 3 H2O + hydrogen sulfide + 3 oxidized coenzyme F420-(gamma-Glu)(n) <=> 3 reduced coenzyme F420-(gamma-Glu)(n) + sulfite","pmd":2.016}
{"X":7256,"KEGG":"R10806","RHEA_ID":57455,"DIRECTION":"BI","MASTER_ID":57452,"compounds":"L-glutaminyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(5)-methyl-L-glutaminyl-[protein] + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7257,"KEGG":"R10807","RHEA_ID":39030,"DIRECTION":"BI","MASTER_ID":39027,"metacyc":"RXN-15118","compounds":"a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + UDP-alpha-D-glucose <=> a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP","pmd":162.053}
{"X":7258,"KEGG":"R10812","RHEA_ID":53047,"DIRECTION":"BI","MASTER_ID":53044,"compounds":"a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine <=> a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7259,"KEGG":"R10815","RHEA_ID":37374,"DIRECTION":"BI","MASTER_ID":37371,"metacyc":"RXN-12817","compounds":"a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + H2O <=> a 5'-end (purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methylguanosine 5'-diphosphate"}
{"X":7260,"KEGG":"R10817","RHEA_ID":42363,"DIRECTION":"BI","MASTER_ID":42360,"metacyc":"RXN-14365","compounds":"D-allulose <=> keto-D-fructose","pmd":0}
{"X":7261,"KEGG":"R10818","RHEA_ID":43051,"DIRECTION":"BI","MASTER_ID":43048,"metacyc":"RXN-14364","compounds":"keto-D-tagatose <=> keto-D-sorbose","pmd":0}
{"X":7262,"KEGG":"R10820","RHEA_ID":43055,"DIRECTION":"BI","MASTER_ID":43052,"compounds":"3-(methylsulfanyl)propanoate + ATP + CoA <=> 3-(methylsulfanyl)propanoyl-CoA + AMP + diphosphate","pmd":159.933}
{"X":7263,"KEGG":"R10820","RHEA_ID":43055,"DIRECTION":"BI","MASTER_ID":43052,"compounds":"3-(methylsulfanyl)propanoate + ATP + CoA <=> 3-(methylsulfanyl)propanoyl-CoA + AMP + diphosphate","pmd":227.039}
{"X":7264,"KEGG":"R10820","RHEA_ID":43055,"DIRECTION":"BI","MASTER_ID":43052,"compounds":"3-(methylsulfanyl)propanoate + ATP + CoA <=> 3-(methylsulfanyl)propanoyl-CoA + AMP + diphosphate","pmd":102.014}
{"X":7265,"KEGG":"R10821","RHEA_ID":27593,"DIRECTION":"BI","MASTER_ID":27590,"compounds":"(R)-pantoate + ATP + beta-alanine <=> (R)-pantothenate + ADP + H(+) + phosphate","pmd":71.037}
{"X":7266,"KEGG":"R10821","RHEA_ID":27593,"DIRECTION":"BI","MASTER_ID":27590,"compounds":"(R)-pantoate + ATP + beta-alanine <=> (R)-pantothenate + ADP + H(+) + phosphate","pmd":79.966}
{"X":7267,"KEGG":"R10825","RHEA_ID":32730,"DIRECTION":"BI","MASTER_ID":32727,"compounds":"a very-long-chain acyl-CoA + H(+) + malonyl-CoA <=> a very-long-chain 3-oxoacyl-CoA + CO2 + CoA","pmd":86}
{"X":7268,"KEGG":"R10826","RHEA_ID":48683,"DIRECTION":"BI","MASTER_ID":48680,"compounds":"a very-long-chain (3R)-hydroxyacyl-CoA + NADP(+) <=> a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH"}
{"X":7269,"KEGG":"R10827","RHEA_ID":45815,"DIRECTION":"BI","MASTER_ID":45812,"compounds":"a very-long-chain (3R)-hydroxyacyl-CoA <=> a very-long-chain (2E)-enoyl-CoA + H2O"}
{"X":7270,"KEGG":"R10828","RHEA_ID":14476,"DIRECTION":"BI","MASTER_ID":14473,"compounds":"a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) <=> a very-long-chain (2E)-enoyl-CoA + H(+) + NADPH"}
{"X":7271,"KEGG":"R10829","RHEA_ID":13148,"DIRECTION":"BI","MASTER_ID":13145,"metacyc":"RXN-15203","compounds":"4-O-beta-D-mannopyranosyl-N-acetyl-D-glucosamine + phosphate <=> alpha-D-mannose 1-phosphate + N-acetyl-D-glucosamine","pmd":123.113}
{"X":7272,"KEGG":"R10832","RHEA_ID":11567,"DIRECTION":"BI","MASTER_ID":11564,"metacyc":"RXN-15204","compounds":"4-O-beta-D-glucopyranosyl-D-gluconate + phosphate <=> alpha-D-glucose 1-phosphate + D-gluconate","pmd":98.081}
{"X":7273,"KEGG":"R10833","RHEA_ID":39894,"DIRECTION":"BI","MASTER_ID":39891,"compounds":"devancoaminyl-vancomycin + dTDP-beta-L-vancosamine <=> dTDP + H(+) + vancomycin","pmd":143.095}
{"X":7274,"KEGG":"R10834","RHEA_ID":39898,"DIRECTION":"BI","MASTER_ID":39895,"compounds":"7-deoxyloganetate + UDP-alpha-D-glucose <=> 7-deoxyloganate + H(+) + UDP","pmd":162.053}
{"X":7275,"KEGG":"R10835","RHEA_ID":39902,"DIRECTION":"BI","MASTER_ID":39899,"metacyc":"RXN-15236","compounds":"7-deoxyloganetin + UDP-alpha-D-glucose <=> 7-deoxyloganin + H(+) + UDP","pmd":162.053}
{"X":7276,"KEGG":"R10839","RHEA_ID":22115,"DIRECTION":"BI","MASTER_ID":22112,"compounds":"isoxazolin-5-one + O-acetyl-L-serine <=> 3-(5-oxoisoxazolin-2-yl)-L-alanine + acetate + H(+)","pmd":24.995}
{"X":7277,"KEGG":"R10840","RHEA_ID":39906,"DIRECTION":"BI","MASTER_ID":39903,"compounds":"isoxazolin-5-one + O-acetyl-L-serine <=> 3-(5-oxoisoxazolin-4-yl)-L-alanine + acetate + H(+)","pmd":24.995}
{"X":7278,"KEGG":"R10841","RHEA_ID":22407,"DIRECTION":"BI","MASTER_ID":22404,"compounds":"beta-D-galacturonate + NAD(+) <=> D-galactaro-1,5-lactone + H(+) + NADH","pmd":472.09}
{"X":7279,"KEGG":"R10841","RHEA_ID":22407,"DIRECTION":"BI","MASTER_ID":22404,"compounds":"beta-D-galacturonate + NAD(+) <=> D-galactaro-1,5-lactone + H(+) + NADH","pmd":2.016}
{"X":7280,"KEGG":"R10842","RHEA_ID":43503,"DIRECTION":"BI","MASTER_ID":43500,"compounds":"beta-D-glucuronate + NAD(+) <=> D-glucaro-1,5-lactone + H(+) + NADH","pmd":472.09}
{"X":7281,"KEGG":"R10842","RHEA_ID":43503,"DIRECTION":"BI","MASTER_ID":43500,"compounds":"beta-D-glucuronate + NAD(+) <=> D-glucaro-1,5-lactone + H(+) + NADH","pmd":2.016}
{"X":7282,"KEGG":"R10843","RHEA_ID":43595,"DIRECTION":"BI","MASTER_ID":43592,"compounds":"all-trans-zeaxanthin + O2 <=> (3R)-3-hydroxy-8'-apo-beta-carotenal + 3beta-hydroxy-beta-cyclocitral","pmd":136.125}
{"X":7283,"KEGG":"R10844","RHEA_ID":43599,"DIRECTION":"BI","MASTER_ID":43596,"compounds":"(3R)-3-hydroxy-8'-apo-beta-carotenal + O2 <=> 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde","pmd":136.125}
{"X":7284,"KEGG":"R10846","RHEA_ID":45583,"DIRECTION":"BI","MASTER_ID":45580,"compounds":"D-galactaro-1,5-lactone <=> D-galactaro-1,4-lactone","pmd":0}
{"X":7285,"KEGG":"R10847","RHEA_ID":45603,"DIRECTION":"BI","MASTER_ID":45600,"compounds":"D-galactaro-1,4-lactone <=> 5-dehydro-4-deoxy-D-glucarate + H(+)","pmd":0}
{"X":7286,"KEGG":"R10848","RHEA_ID":43499,"DIRECTION":"BI","MASTER_ID":43496,"compounds":"L-gulonate + NAD(+) <=> H(+) + keto-D-fructuronate + NADH","pmd":470.074}
{"X":7287,"KEGG":"R10848","RHEA_ID":43499,"DIRECTION":"BI","MASTER_ID":43496,"compounds":"L-gulonate + NAD(+) <=> H(+) + keto-D-fructuronate + NADH","pmd":2.016}
{"X":7288,"KEGG":"R10850","RHEA_ID":47615,"DIRECTION":"BI","MASTER_ID":47612,"compounds":"a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose <=> a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + H(+) + UDP","pmd":162.053}
{"X":7289,"KEGG":"R10851","RHEA_ID":30058,"DIRECTION":"BI","MASTER_ID":30055,"compounds":"L-allo-threonine + NADP(+) <=> (2S)-2-amino-3-oxobutanoate + H(+) + NADPH","pmd":2.016}
{"X":7290,"KEGG":"R10851","RHEA_ID":30058,"DIRECTION":"BI","MASTER_ID":30055,"compounds":"L-allo-threonine + NADP(+) <=> (2S)-2-amino-3-oxobutanoate + H(+) + NADPH","pmd":627.041}
{"X":7291,"KEGG":"R10852","RHEA_ID":43527,"DIRECTION":"BI","MASTER_ID":43524,"compounds":"L-allo-threonine + NADP(+) <=> aminoacetone + CO2 + NADPH","pmd":626.033}
{"X":7292,"KEGG":"R10853","RHEA_ID":43507,"DIRECTION":"BI","MASTER_ID":43504,"compounds":"5-hydroxymethylfurfural + O2 <=> 2,5-diformylfuran + H2O2","pmd":2.016}
{"X":7293,"KEGG":"R10854","RHEA_ID":43511,"DIRECTION":"BI","MASTER_ID":43508,"compounds":"2,5-diformylfuran + H2O <=> 2-(dihydroxymethyl)-5-formylfuran","pmd":18.011}
{"X":7294,"KEGG":"R10855","RHEA_ID":43515,"DIRECTION":"BI","MASTER_ID":43512,"compounds":"2-(dihydroxymethyl)-5-formylfuran + O2 <=> 2-carboxy-5-formylfuran + H(+) + H2O2","pmd":2.016}
{"X":7295,"KEGG":"R10856","RHEA_ID":43519,"DIRECTION":"BI","MASTER_ID":43516,"compounds":"2-carboxy-5-formylfuran + H2O <=> 2-carboxy-5-(dihydroxymethyl)furan","pmd":18.011}
{"X":7296,"KEGG":"R10857","RHEA_ID":43523,"DIRECTION":"BI","MASTER_ID":43520,"compounds":"2-carboxy-5-(dihydroxymethyl)furan + O2 <=> 2,5-dicarboxyfuran + H(+) + H2O2","pmd":2.016}
{"X":7297,"KEGG":"R10858","RHEA_ID":32686,"DIRECTION":"BI","MASTER_ID":32683,"compounds":"5-hydroxymethylfurfural + 2 H2O + 3 O2 <=> 2,5-dicarboxyfuran + 2 H(+) + 3 H2O2","pmd":29.974}
{"X":7298,"KEGG":"R10859","RHEA_ID":43607,"DIRECTION":"BI","MASTER_ID":43604,"compounds":"(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] <=> 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]","pmd":15.995}
{"X":7299,"KEGG":"R10860","RHEA_ID":42763,"DIRECTION":"BI","MASTER_ID":42760,"metacyc":"RXN-15754","compounds":"D-glyceraldehyde 3-phosphate + H2O + NAD(+) <=> (2R)-3-phosphoglycerate + 2 H(+) + NADH","pmd":15.995}
{"X":7300,"KEGG":"R10860","RHEA_ID":42763,"DIRECTION":"BI","MASTER_ID":42760,"metacyc":"RXN-15754","compounds":"D-glyceraldehyde 3-phosphate + H2O + NAD(+) <=> (2R)-3-phosphoglycerate + 2 H(+) + NADH","pmd":478.124}
{"X":7301,"KEGG":"R10861","RHEA_ID":43571,"DIRECTION":"BI","MASTER_ID":43568,"compounds":"3,6-anhydro-alpha-L-galactopyranose + H2O + NAD(+) <=> 3,6-anhydro-L-galactonate + 2 H(+) + NADH","pmd":15.995}
{"X":7302,"KEGG":"R10861","RHEA_ID":43571,"DIRECTION":"BI","MASTER_ID":43568,"compounds":"3,6-anhydro-alpha-L-galactopyranose + H2O + NAD(+) <=> 3,6-anhydro-L-galactonate + 2 H(+) + NADH","pmd":486.069}
{"X":7303,"KEGG":"R10862","RHEA_ID":40806,"DIRECTION":"BI","MASTER_ID":40803,"compounds":"3,6-anhydro-alpha-L-galactopyranose + H2O + NADP(+) <=> 3,6-anhydro-L-galactonate + 2 H(+) + NADPH","pmd":566.036}
{"X":7304,"KEGG":"R10862","RHEA_ID":40806,"DIRECTION":"BI","MASTER_ID":40803,"compounds":"3,6-anhydro-alpha-L-galactopyranose + H2O + NADP(+) <=> 3,6-anhydro-L-galactonate + 2 H(+) + NADPH","pmd":15.995}
{"X":7305,"KEGG":"R10865","RHEA_ID":52699,"DIRECTION":"BI","MASTER_ID":52696,"compounds":"a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-galactose <=> a 1,2-diacyl-3-O-[alpha-D-galactopyranosyl-(1->2)-alpha-D-glucopyranosyl]-sn-glycerol + H(+) + UDP","pmd":162.053}
{"X":7306,"KEGG":"R10867","RHEA_ID":31650,"DIRECTION":"BI","MASTER_ID":31647,"compounds":"beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc6S + H2O <=> 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine 6-sulfate","pmd":158.022}
{"X":7307,"KEGG":"R10868","RHEA_ID":54307,"DIRECTION":"BI","MASTER_ID":54304,"compounds":"n 3'-phosphoadenylyl sulfate + dermatan 4'-sulfate <=> n adenosine 3',5'-bisphosphate + dermatan 4',6'-disulfate + n H(+)","pmd":79.957}
{"X":7308,"KEGG":"R10869","RHEA_ID":54303,"DIRECTION":"BI","MASTER_ID":54300,"compounds":"n 3'-phosphoadenylyl sulfate + chondroitin 4'-sulfate <=> n adenosine 3',5'-bisphosphate + chondroitin 4',6'-disulfate + n H(+)","pmd":79.957}
{"X":7309,"KEGG":"R10873","RHEA_ID":48055,"DIRECTION":"BI","MASTER_ID":48052,"compounds":"n 3'-phosphoadenylyl sulfate + dermatan <=> n adenosine 3',5'-bisphosphate + dermatan 4'-sulfate + n H(+)","pmd":79.957}
{"X":7310,"KEGG":"R10881","RHEA_ID":49711,"DIRECTION":"BI","MASTER_ID":49708,"compounds":"nocardicin G + S-adenosyl-L-methionine <=> H(+) + isonocardicin C + S-methyl-5'-thioadenosine","pmd":88.038}
{"X":7311,"KEGG":"R10883","RHEA_ID":42135,"DIRECTION":"BI","MASTER_ID":42132,"compounds":"isonocardicin C <=> nocardicin C","pmd":0}
{"X":7312,"KEGG":"R10896","RHEA_ID":42991,"DIRECTION":"BI","MASTER_ID":42988,"compounds":"all-trans-geranylgeranyl diphosphate <=> cembrene C + diphosphate","pmd":177.943}
{"X":7313,"KEGG":"R10897","RHEA_ID":42995,"DIRECTION":"BI","MASTER_ID":42992,"compounds":"all-trans-geranylgeranyl diphosphate + H2O <=> (R)-nephthenol + diphosphate","pmd":159.933}
{"X":7314,"KEGG":"R10898","RHEA_ID":42999,"DIRECTION":"BI","MASTER_ID":42996,"compounds":"all-trans-geranylgeranyl diphosphate <=> (R)-cembrene A + diphosphate","pmd":177.943}
{"X":7315,"KEGG":"R10899","RHEA_ID":43003,"DIRECTION":"BI","MASTER_ID":43000,"compounds":"all-trans-geranylgeranyl diphosphate + H2O <=> (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol + diphosphate","pmd":159.933}
{"X":7316,"KEGG":"R10900","RHEA_ID":21515,"DIRECTION":"BI","MASTER_ID":21512,"compounds":"3,6-anhydro-L-galactonate <=> 2-dehydro-3-deoxy-L-galactonate","pmd":0}
{"X":7317,"KEGG":"R10901","RHEA_ID":29566,"DIRECTION":"BI","MASTER_ID":29563,"compounds":"ATP + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramate <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate","pmd":252.073}
{"X":7318,"KEGG":"R10901","RHEA_ID":29566,"DIRECTION":"BI","MASTER_ID":29563,"compounds":"ATP + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramate <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate","pmd":79.966}
{"X":7319,"KEGG":"R10901","RHEA_ID":29566,"DIRECTION":"BI","MASTER_ID":29563,"compounds":"ATP + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramate <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate","pmd":36.854}
{"X":7320,"KEGG":"R10902","RHEA_ID":43547,"DIRECTION":"BI","MASTER_ID":43544,"compounds":"ATP + L-glutamate + tyramine <=> ADP + gamma-L-glutamyltyramine + H(+) + phosphate","pmd":119.074}
{"X":7321,"KEGG":"R10902","RHEA_ID":43547,"DIRECTION":"BI","MASTER_ID":43544,"compounds":"ATP + L-glutamate + tyramine <=> ADP + gamma-L-glutamyltyramine + H(+) + phosphate","pmd":129.043}
{"X":7322,"KEGG":"R10902","RHEA_ID":43547,"DIRECTION":"BI","MASTER_ID":43544,"compounds":"ATP + L-glutamate + tyramine <=> ADP + gamma-L-glutamyltyramine + H(+) + phosphate","pmd":79.966}
{"X":7323,"KEGG":"R10906","RHEA_ID":44015,"DIRECTION":"BI","MASTER_ID":44012,"compounds":"(9Z)-hexadecenoyl-[ACP] + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA <=> (9Z)-hexadecenoyl-(Kdo)2-lipid IVA + holo-[ACP]"}
{"X":7324,"KEGG":"R10908","RHEA_ID":33870,"DIRECTION":"BI","MASTER_ID":33867,"metacyc":"RXN-11141","compounds":"(S)-2-ureidoglycine + glyoxylate <=> glycine + N-carbamoyl-2-oxoglycine","pmd":1.032}
{"X":7325,"KEGG":"R10909","RHEA_ID":34410,"DIRECTION":"BI","MASTER_ID":34407,"compounds":"3 ATP <=> 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 diphosphate"}
{"X":7326,"KEGG":"R10911","RHEA_ID":13884,"DIRECTION":"BI","MASTER_ID":13881,"compounds":"a quinone + an aldehyde + H2O <=> a carboxylate + a quinol + H(+)"}
{"X":7327,"KEGG":"R10913","RHEA_ID":45043,"DIRECTION":"BI","MASTER_ID":45040,"compounds":"2 [Fe(III)cytochrome c] + hydroxylamine <=> 2 [Fe(II)cytochrome c] + 2 H(+) + nitroxyl"}
{"X":7328,"KEGG":"R10914","RHEA_ID":45047,"DIRECTION":"BI","MASTER_ID":45044,"compounds":"2 [Fe(II)cytochrome c] + H(+) + nitroxyl + O2 <=> 2 [Fe(III)cytochrome c] + H2O + nitrite"}
{"X":7329,"KEGG":"R10915","RHEA_ID":28089,"DIRECTION":"BI","MASTER_ID":28086,"metacyc":"RXN-11813","compounds":"2 H2O2 + Reactive Blue 5 <=> 2,2'-disulfonyl azobenzene + 3-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]benzenesulfonate + 2 H(+) + 2 H2O + phthalate","pmd":431.009}
{"X":7330,"KEGG":"R10916","RHEA_ID":30630,"DIRECTION":"BI","MASTER_ID":30627,"metacyc":"RXN-16060","compounds":"(2R)-2,3-dihydroxy-3-methylbutanoate + NAD(+) <=> (2S)-2-acetolactate + H(+) + NADH","pmd":532.075}
{"X":7331,"KEGG":"R10916","RHEA_ID":30630,"DIRECTION":"BI","MASTER_ID":30627,"metacyc":"RXN-16060","compounds":"(2R)-2,3-dihydroxy-3-methylbutanoate + NAD(+) <=> (2S)-2-acetolactate + H(+) + NADH","pmd":2.016}
{"X":7332,"KEGG":"R10916","RHEA_ID":30630,"DIRECTION":"BI","MASTER_ID":30627,"metacyc":"RXN-16061","compounds":"(2R)-2,3-dihydroxy-3-methylbutanoate + NAD(+) <=> (2S)-2-acetolactate + H(+) + NADH","pmd":532.075}
{"X":7333,"KEGG":"R10916","RHEA_ID":30630,"DIRECTION":"BI","MASTER_ID":30627,"metacyc":"RXN-16061","compounds":"(2R)-2,3-dihydroxy-3-methylbutanoate + NAD(+) <=> (2S)-2-acetolactate + H(+) + NADH","pmd":2.016}
{"X":7334,"KEGG":"R10917","RHEA_ID":44631,"DIRECTION":"BI","MASTER_ID":44628,"compounds":"L-dihydroanticapsin + NAD(+) <=> H(+) + L-anticapsin + NADH","pmd":465.032}
{"X":7335,"KEGG":"R10917","RHEA_ID":44631,"DIRECTION":"BI","MASTER_ID":44628,"compounds":"L-dihydroanticapsin + NAD(+) <=> H(+) + L-anticapsin + NADH","pmd":2.016}
{"X":7336,"KEGG":"R10918","RHEA_ID":45123,"DIRECTION":"BI","MASTER_ID":45120,"metacyc":"RXN-15051","compounds":"(4R)-ipsdienol + NAD(+) <=> H(+) + ipsdienone + NADH","pmd":2.016}
{"X":7337,"KEGG":"R10918","RHEA_ID":45123,"DIRECTION":"BI","MASTER_ID":45120,"metacyc":"RXN-15051","compounds":"(4R)-ipsdienol + NAD(+) <=> H(+) + ipsdienone + NADH","pmd":514.012}
{"X":7338,"KEGG":"R10919","RHEA_ID":45119,"DIRECTION":"BI","MASTER_ID":45116,"metacyc":"RXN-15051","compounds":"(4R)-ipsdienol + NADP(+) <=> H(+) + ipsdienone + NADPH","pmd":2.016}
{"X":7339,"KEGG":"R10919","RHEA_ID":45119,"DIRECTION":"BI","MASTER_ID":45116,"metacyc":"RXN-15051","compounds":"(4R)-ipsdienol + NADP(+) <=> H(+) + ipsdienone + NADPH","pmd":593.979}
{"X":7340,"KEGG":"R10920","RHEA_ID":43123,"DIRECTION":"BI","MASTER_ID":43120,"compounds":"2-oxoglutarate + O2 + xanthine <=> CO2 + succinate + urate","pmd":22.007}
{"X":7341,"KEGG":"R10920","RHEA_ID":43123,"DIRECTION":"BI","MASTER_ID":43120,"compounds":"2-oxoglutarate + O2 + xanthine <=> CO2 + succinate + urate","pmd":15.995}
{"X":7342,"KEGG":"R10921","RHEA_ID":43075,"DIRECTION":"BI","MASTER_ID":43072,"compounds":"beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> erythrodiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":7343,"KEGG":"R10922","RHEA_ID":43079,"DIRECTION":"BI","MASTER_ID":43076,"compounds":"erythrodiol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oleanolic aldehyde + oxidized [NADPH--hemoprotein reductase]","pmd":2.016}
{"X":7344,"KEGG":"R10923","RHEA_ID":43083,"DIRECTION":"BI","MASTER_ID":43080,"compounds":"O2 + oleanolic aldehyde + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + oleanolate + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":7345,"KEGG":"R10924","RHEA_ID":43071,"DIRECTION":"BI","MASTER_ID":43068,"compounds":"beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 4 H(+) + 4 H2O + oleanolate + 3 oxidized [NADPH--hemoprotein reductase]","pmd":29.974}
{"X":7346,"KEGG":"R10925","RHEA_ID":43727,"DIRECTION":"BI","MASTER_ID":43724,"compounds":"(2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + juvenile hormone III carboxylate + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":7347,"KEGG":"R10926","RHEA_ID":45467,"DIRECTION":"BI","MASTER_ID":45464,"compounds":"2 [Fe(II)-cytochrome b5] + eicosanoyl-CoA + 2 H(+) + O2 <=> (5Z)-eicosenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":7348,"KEGG":"R10929","RHEA_ID":52627,"DIRECTION":"BI","MASTER_ID":52624,"compounds":"[amino group carrier protein]-C-terminal-L-glutamate + ATP + L-glutamate <=> [amino group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ADP + H(+) + phosphate","pmd":279.976}
{"X":7349,"KEGG":"R10929","RHEA_ID":52627,"DIRECTION":"BI","MASTER_ID":52624,"compounds":"[amino group carrier protein]-C-terminal-L-glutamate + ATP + L-glutamate <=> [amino group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ADP + H(+) + phosphate","pmd":79.966}
{"X":7350,"KEGG":"R10930","RHEA_ID":52635,"DIRECTION":"BI","MASTER_ID":52632,"compounds":"[amino group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ATP <=> [amino group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + ADP","pmd":79.966}
{"X":7351,"KEGG":"R10931","RHEA_ID":52671,"DIRECTION":"BI","MASTER_ID":52668,"compounds":"[amino group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + NADP(+) + phosphate <=> [amino group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + H(+) + NADPH"}
{"X":7352,"KEGG":"R10932","RHEA_ID":52675,"DIRECTION":"BI","MASTER_ID":52672,"metacyc":"RXN-15007","compounds":"2-oxoglutarate + [amino group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate <=> [amino group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + L-glutamate","pmd":1.032}
{"X":7353,"KEGG":"R10933","RHEA_ID":52679,"DIRECTION":"BI","MASTER_ID":52676,"compounds":"[amino group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + H2O <=> [amino group carrier protein]-C-terminal-L-glutamate + L-ornithine"}
{"X":7354,"KEGG":"R10934","RHEA_ID":33502,"DIRECTION":"BI","MASTER_ID":33499,"compounds":"H(+) + prephenate <=> 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate + CO2","pmd":43.99}
{"X":7355,"KEGG":"R10935","RHEA_ID":43539,"DIRECTION":"BI","MASTER_ID":43536,"compounds":"2 D-glyceraldehyde 3-phosphate <=> 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + 2 H2O + phosphate","pmd":36}
{"X":7356,"KEGG":"R10936","RHEA_ID":45147,"DIRECTION":"BI","MASTER_ID":45144,"compounds":"3-(methylsulfanyl)acryloyl-CoA + 2 H2O <=> acetaldehyde + CO2 + CoA + methanethiol","pmd":99.998}
{"X":7357,"KEGG":"R10937","RHEA_ID":44187,"DIRECTION":"BI","MASTER_ID":44184,"compounds":"D-sedoheptulose 7-phosphate <=> 2-epi-5-epi-valiolone + phosphate","pmd":97.977}
{"X":7358,"KEGG":"R10939","RHEA_ID":44363,"DIRECTION":"BI","MASTER_ID":44360,"compounds":"(S)-4-hydroxy-2,3-pentanedione-5-phosphate <=> 3-hydroxy-2,4-pentanedione 5-phosphate","pmd":0}
{"X":7359,"KEGG":"R10940","RHEA_ID":44343,"DIRECTION":"BI","MASTER_ID":44340,"compounds":"(S)-2,3-diaminopropanoate + ATP + fumarate <=> AMP + diphosphate + N(3)-fumaroyl-(S)-2,3-diaminopropanoate","pmd":159.933}
{"X":7360,"KEGG":"R10940","RHEA_ID":44343,"DIRECTION":"BI","MASTER_ID":44340,"compounds":"(S)-2,3-diaminopropanoate + ATP + fumarate <=> AMP + diphosphate + N(3)-fumaroyl-(S)-2,3-diaminopropanoate","pmd":98}
{"X":7361,"KEGG":"R10940","RHEA_ID":44343,"DIRECTION":"BI","MASTER_ID":44340,"compounds":"(S)-2,3-diaminopropanoate + ATP + fumarate <=> AMP + diphosphate + N(3)-fumaroyl-(S)-2,3-diaminopropanoate","pmd":86.048}
{"X":7362,"KEGG":"R10941","RHEA_ID":45083,"DIRECTION":"BI","MASTER_ID":45080,"compounds":"3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine + ATP + L-valine <=> ADP + dapdiamide E + H(+) + phosphate","pmd":99.068}
{"X":7363,"KEGG":"R10941","RHEA_ID":45083,"DIRECTION":"BI","MASTER_ID":45080,"compounds":"3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine + ATP + L-valine <=> ADP + dapdiamide E + H(+) + phosphate","pmd":199.059}
{"X":7364,"KEGG":"R10941","RHEA_ID":45083,"DIRECTION":"BI","MASTER_ID":45080,"compounds":"3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine + ATP + L-valine <=> ADP + dapdiamide E + H(+) + phosphate","pmd":79.966}
{"X":7365,"KEGG":"R10942","RHEA_ID":44347,"DIRECTION":"BI","MASTER_ID":44344,"compounds":"ATP + L-valine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate <=> ADP + dapdiamide A + H(+) + phosphate","pmd":183.064}
{"X":7366,"KEGG":"R10942","RHEA_ID":44347,"DIRECTION":"BI","MASTER_ID":44344,"compounds":"ATP + L-valine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate <=> ADP + dapdiamide A + H(+) + phosphate","pmd":79.966}
{"X":7367,"KEGG":"R10942","RHEA_ID":44347,"DIRECTION":"BI","MASTER_ID":44344,"compounds":"ATP + L-valine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate <=> ADP + dapdiamide A + H(+) + phosphate","pmd":99.068}
{"X":7368,"KEGG":"R10943","RHEA_ID":44351,"DIRECTION":"BI","MASTER_ID":44348,"compounds":"ATP + L-isoleucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate <=> ADP + dapdiamide B + H(+) + phosphate","pmd":183.064}
{"X":7369,"KEGG":"R10943","RHEA_ID":44351,"DIRECTION":"BI","MASTER_ID":44348,"compounds":"ATP + L-isoleucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate <=> ADP + dapdiamide B + H(+) + phosphate","pmd":79.966}
{"X":7370,"KEGG":"R10943","RHEA_ID":44351,"DIRECTION":"BI","MASTER_ID":44348,"compounds":"ATP + L-isoleucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate <=> ADP + dapdiamide B + H(+) + phosphate","pmd":113.084}
{"X":7371,"KEGG":"R10944","RHEA_ID":44355,"DIRECTION":"BI","MASTER_ID":44352,"compounds":"ATP + L-leucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate <=> ADP + dapdiamide C + H(+) + phosphate","pmd":113.084}
{"X":7372,"KEGG":"R10944","RHEA_ID":44355,"DIRECTION":"BI","MASTER_ID":44352,"compounds":"ATP + L-leucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate <=> ADP + dapdiamide C + H(+) + phosphate","pmd":183.064}
{"X":7373,"KEGG":"R10944","RHEA_ID":44355,"DIRECTION":"BI","MASTER_ID":44352,"compounds":"ATP + L-leucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate <=> ADP + dapdiamide C + H(+) + phosphate","pmd":79.966}
{"X":7374,"KEGG":"R10945","RHEA_ID":45151,"DIRECTION":"BI","MASTER_ID":45148,"compounds":"3-(methylsulfanyl)acryloyl-CoA + H2O <=> 3-hydroxy-3-(methylsulfanyl)propanoyl-CoA","pmd":18.011}
{"X":7375,"KEGG":"R10946","RHEA_ID":45155,"DIRECTION":"BI","MASTER_ID":45152,"compounds":"3-hydroxy-3-(methylsulfanyl)propanoyl-CoA <=> 3-oxopropanoyl-CoA + methanethiol","pmd":48.003}
{"X":7376,"KEGG":"R10947","RHEA_ID":45159,"DIRECTION":"BI","MASTER_ID":45156,"compounds":"3-oxopropanoyl-CoA + H2O <=> 3-oxopropanoate + CoA + H(+)","pmd":70.006}
{"X":7377,"KEGG":"R10948","RHEA_ID":46747,"DIRECTION":"BI","MASTER_ID":46744,"compounds":"ATP + hydrogencarbonate <=> ADP + carboxyphosphate","pmd":79.966}
{"X":7378,"KEGG":"R10949","RHEA_ID":46751,"DIRECTION":"BI","MASTER_ID":46748,"compounds":"carboxyphosphate + NH4(+) <=> carbamate + 2 H(+) + phosphate"}
{"X":7379,"KEGG":"R10955","RHEA_ID":42851,"DIRECTION":"BI","MASTER_ID":42848,"compounds":"8-demethyltetracenomycin C + dTDP-beta-L-rhamnose <=> 8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + dTDP + H(+)","pmd":56.062}
{"X":7380,"KEGG":"R10960","RHEA_ID":21351,"DIRECTION":"BI","MASTER_ID":21348,"compounds":"8 H(+) + 10 malonyl-CoA <=> 10 CO2 + 10 CoA + 2 H2O + tetracenomycin F2","pmd":86}
{"X":7381,"KEGG":"R10967","RHEA_ID":50383,"DIRECTION":"BI","MASTER_ID":50380,"compounds":"3 H(+) + 3 malonyl-CoA <=> 1,3,5-trihydroxybenzene + 3 CO2 + 3 CoA","pmd":86}
{"X":7382,"KEGG":"R10971","RHEA_ID":41611,"DIRECTION":"BI","MASTER_ID":41608,"compounds":"3'-phosphoadenylyl sulfate + alpha,alpha-trehalose <=> 2-O-sulfo-alpha,alpha-trehalose + adenosine 3',5'-bisphosphate + H(+)","pmd":79.957}
{"X":7383,"KEGG":"R10974","RHEA_ID":41627,"DIRECTION":"BI","MASTER_ID":41624,"compounds":"3-sulfinopropanoyl-CoA + H2O <=> H(+) + propanoyl-CoA + sulfite","pmd":63.962}
{"X":7384,"KEGG":"R10975","RHEA_ID":18228,"DIRECTION":"BI","MASTER_ID":18225,"compounds":"[N-(6-aminohexanoyl)](n) + H2O <=> 6-aminohexanoate + [N-(6-aminohexanoyl)](n-1)"}
{"X":7385,"KEGG":"R10982","RHEA_ID":57835,"DIRECTION":"BI","MASTER_ID":57832,"compounds":"5-oxopentanoate + H2O + NADP(+) <=> glutarate + 2 H(+) + NADPH","pmd":15.995}
{"X":7386,"KEGG":"R10982","RHEA_ID":57835,"DIRECTION":"BI","MASTER_ID":57832,"compounds":"5-oxopentanoate + H2O + NADP(+) <=> glutarate + 2 H(+) + NADPH","pmd":612.041}
{"X":7387,"KEGG":"R10984","RHEA_ID":43623,"DIRECTION":"BI","MASTER_ID":43620,"compounds":"L-serine + NADP(+) <=> aminoacetaldehyde + CO2 + NADPH","pmd":640.048}
{"X":7388,"KEGG":"R10985","RHEA_ID":43531,"DIRECTION":"BI","MASTER_ID":43528,"compounds":"L-serine + NAD(+) <=> 2-aminomalonate semialdehyde + H(+) + NADH","pmd":2.016}
{"X":7389,"KEGG":"R10985","RHEA_ID":43531,"DIRECTION":"BI","MASTER_ID":43528,"compounds":"L-serine + NAD(+) <=> 2-aminomalonate semialdehyde + H(+) + NADH","pmd":561.09}
{"X":7390,"KEGG":"R10986","RHEA_ID":43631,"DIRECTION":"BI","MASTER_ID":43628,"metacyc":"RXN-16008","compounds":"L-serine + NAD(+) <=> aminoacetaldehyde + CO2 + NADH","pmd":560.082}
{"X":7391,"KEGG":"R10988","RHEA_ID":42391,"DIRECTION":"BI","MASTER_ID":42388,"compounds":"beta-D-glucosyl crocetin + UDP-alpha-D-glucose <=> beta-D-gentiobiosyl crocetin + H(+) + UDP","pmd":86.218}
{"X":7392,"KEGG":"R10989","RHEA_ID":30902,"DIRECTION":"BI","MASTER_ID":30899,"compounds":"bis(beta-D-glucosyl) crocetin + UDP-alpha-D-glucose <=> beta-D-gentiobiosyl beta-D-glucosyl crocetin + H(+) + UDP","pmd":162.053}
{"X":7393,"KEGG":"R10990","RHEA_ID":38862,"DIRECTION":"BI","MASTER_ID":38859,"compounds":"beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP-alpha-D-glucose <=> bis(beta-D-gentiobiosyl) crocetin + H(+) + UDP","pmd":162.053}
{"X":7394,"KEGG":"R10999","RHEA_ID":45075,"DIRECTION":"BI","MASTER_ID":45072,"compounds":"(9Z)-octadecenoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase] <=> (9Z)-18-hydroxyoctadecenoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":7395,"KEGG":"R11000","RHEA_ID":45079,"DIRECTION":"BI","MASTER_ID":45076,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase] <=> (9Z,12Z)-18-hydroxyoctadecadienoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":7396,"KEGG":"R11002","RHEA_ID":46363,"DIRECTION":"BI","MASTER_ID":46360,"compounds":"1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 1-acyl-2-[(R)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":7397,"KEGG":"R11003","RHEA_ID":46515,"DIRECTION":"BI","MASTER_ID":46512,"compounds":"2 [Fe(II)-cytochrome b5] + an N-(1,2-saturated acyl)sphinganine + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + an N-[(2'R)-hydroxyacyl]sphinganine + H2O"}
{"X":7398,"KEGG":"R11004","RHEA_ID":46447,"DIRECTION":"BI","MASTER_ID":46444,"compounds":"(11Z)-hexadecenoyl-CoA + AH2 + O2 <=> (10E,12Z)-hexadecadienoyl-CoA + A + 2 H2O"}
{"X":7399,"KEGG":"R11005","RHEA_ID":46283,"DIRECTION":"BI","MASTER_ID":46280,"compounds":"2 [Fe(II)-cytochrome b5] + an N-acylsphing-4-enine + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 H2O"}
{"X":7400,"KEGG":"R11006","RHEA_ID":46551,"DIRECTION":"BI","MASTER_ID":46548,"compounds":"2 [Fe(II)-cytochrome b5] + a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + 2 H2O + N-acyl-(4E,8E,10E)-sphingatrienine"}
{"X":7401,"KEGG":"R11007","RHEA_ID":51647,"DIRECTION":"BI","MASTER_ID":51644,"compounds":"cholesterol + H(+) + NADH + O2 <=> cholesta-5,7-dien-3beta-ol + 2 H2O + NAD(+)","pmd":2.016}
{"X":7402,"KEGG":"R11007","RHEA_ID":51647,"DIRECTION":"BI","MASTER_ID":51644,"compounds":"cholesterol + H(+) + NADH + O2 <=> cholesta-5,7-dien-3beta-ol + 2 H2O + NAD(+)","pmd":280.786}
{"X":7403,"KEGG":"R11008","RHEA_ID":45027,"DIRECTION":"BI","MASTER_ID":45024,"compounds":"cholesterol + H(+) + NADPH + O2 <=> cholesta-5,7-dien-3beta-ol + 2 H2O + NADP(+)","pmd":2.016}
{"X":7404,"KEGG":"R11008","RHEA_ID":45027,"DIRECTION":"BI","MASTER_ID":45024,"compounds":"cholesterol + H(+) + NADPH + O2 <=> cholesta-5,7-dien-3beta-ol + 2 H2O + NADP(+)","pmd":360.752}
{"X":7405,"KEGG":"R11009","RHEA_ID":46271,"DIRECTION":"BI","MASTER_ID":46268,"compounds":"2 [Fe(II)-cytochrome b5] + an N-acyl-(4R)-4-hydroxysphinganine + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a (4R,8E)-4-hydroxysphingenine ceramide + 2 H2O"}
{"X":7406,"KEGG":"R11010","RHEA_ID":46275,"DIRECTION":"BI","MASTER_ID":46272,"compounds":"2 [Fe(II)-cytochrome b5] + an N-acyl-(4R)-4-hydroxysphinganine + 2 H(+) + O2 <=> (4R,8Z)-4-hydroxysphing-8-enine ceramide + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":7407,"KEGG":"R11011","RHEA_ID":46247,"DIRECTION":"BI","MASTER_ID":46244,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 <=> (14E)-hexadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":7408,"KEGG":"R11012","RHEA_ID":46251,"DIRECTION":"BI","MASTER_ID":46248,"metacyc":"RXN-16231","compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 <=> (14Z)-hexadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":7409,"KEGG":"R11013","RHEA_ID":42675,"DIRECTION":"BI","MASTER_ID":42672,"compounds":"hercynine + L-gamma-glutamyl-L-cysteine + O2 <=> H2O + L-gamma-glutamyl-hercynylcysteine S-oxide","pmd":264.042}
{"X":7410,"KEGG":"R11013","RHEA_ID":42675,"DIRECTION":"BI","MASTER_ID":42672,"compounds":"hercynine + L-gamma-glutamyl-L-cysteine + O2 <=> H2O + L-gamma-glutamyl-hercynylcysteine S-oxide","pmd":212.104}
{"X":7411,"KEGG":"R11015","RHEA_ID":42679,"DIRECTION":"BI","MASTER_ID":42676,"compounds":"L-cysteine + L-histidine + O2 <=> H2O + L-alanin-3-yl L-histidin-5-yl sulfoxide","pmd":134.999}
{"X":7412,"KEGG":"R11015","RHEA_ID":42679,"DIRECTION":"BI","MASTER_ID":42676,"compounds":"L-cysteine + L-histidine + O2 <=> H2O + L-alanin-3-yl L-histidin-5-yl sulfoxide","pmd":169.049}
{"X":7413,"KEGG":"R11016","RHEA_ID":43583,"DIRECTION":"BI","MASTER_ID":43580,"compounds":"A + D-arginine <=> AH2 + iminoarginine","pmd":2.016}
{"X":7414,"KEGG":"R11017","RHEA_ID":43587,"DIRECTION":"BI","MASTER_ID":43584,"compounds":"H2O + iminoarginine <=> 5-guanidino-2-oxopentanoate + NH4(+)","pmd":0.984}
{"X":7415,"KEGG":"R11018","RHEA_ID":43575,"DIRECTION":"BI","MASTER_ID":43572,"metacyc":"RXN-7563","compounds":"A + D-arginine + H2O <=> 5-guanidino-2-oxopentanoate + AH2 + NH4(+)","pmd":1.032}
{"X":7416,"KEGG":"R11021","RHEA_ID":42687,"DIRECTION":"BI","MASTER_ID":42684,"compounds":"H2O + L-gamma-glutamyl-hercynylcysteine S-oxide <=> L-glutamate + S-(hercyn-2-yl)-L-cysteine S-oxide","pmd":129.043}
{"X":7417,"KEGG":"R11023","RHEA_ID":42691,"DIRECTION":"BI","MASTER_ID":42688,"compounds":"AH2 + H(+) + S-(hercyn-2-yl)-L-cysteine S-oxide <=> A + ergothioneine + NH4(+) + pyruvate","pmd":103.027}
{"X":7418,"KEGG":"R11024","RHEA_ID":53723,"DIRECTION":"BI","MASTER_ID":53720,"compounds":"ATP + N-acetyl-D-muramate <=> ADP + H(+) + N-acetyl-alpha-D-muramate 1-phosphate","pmd":79.966}
{"X":7419,"KEGG":"R11030","RHEA_ID":52639,"DIRECTION":"BI","MASTER_ID":52636,"compounds":"2-oxoglutarate + a 5-methyl-2'-deoxycytidine in DNA + O2 <=> a 5-hydroxymethyl-2'-deoxycytidine in DNA + CO2 + succinate","pmd":27.995}
{"X":7420,"KEGG":"R11031","RHEA_ID":47635,"DIRECTION":"BI","MASTER_ID":47632,"compounds":"H2O + L-arginine + NAD(+) <=> 5-guanidino-2-oxopentanoate + H(+) + NADH + NH4(+)","pmd":1.032}
{"X":7421,"KEGG":"R11031","RHEA_ID":47635,"DIRECTION":"BI","MASTER_ID":47632,"compounds":"H2O + L-arginine + NAD(+) <=> 5-guanidino-2-oxopentanoate + H(+) + NADH + NH4(+)","pmd":491.013}
{"X":7422,"KEGG":"R11032","RHEA_ID":47639,"DIRECTION":"BI","MASTER_ID":47636,"compounds":"H2O + L-arginine + NADP(+) <=> 5-guanidino-2-oxopentanoate + H(+) + NADPH + NH4(+)","pmd":570.979}
{"X":7423,"KEGG":"R11032","RHEA_ID":47639,"DIRECTION":"BI","MASTER_ID":47636,"compounds":"H2O + L-arginine + NADP(+) <=> 5-guanidino-2-oxopentanoate + H(+) + NADPH + NH4(+)","pmd":1.032}
{"X":7424,"KEGG":"R11034","RHEA_ID":47983,"DIRECTION":"BI","MASTER_ID":47980,"compounds":"dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose <=> dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose","pmd":0}
{"X":7425,"KEGG":"R11035","RHEA_ID":47991,"DIRECTION":"BI","MASTER_ID":47988,"compounds":"2-dehydro-3-deoxy-L-galactonate + NAD(+) <=> 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH","pmd":2.016}
{"X":7426,"KEGG":"R11035","RHEA_ID":47991,"DIRECTION":"BI","MASTER_ID":47988,"compounds":"2-dehydro-3-deoxy-L-galactonate + NAD(+) <=> 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH","pmd":488.085}
{"X":7427,"KEGG":"R11036","RHEA_ID":47899,"DIRECTION":"BI","MASTER_ID":47896,"compounds":"6-sulfo-D-quinovose + NAD(+) <=> 6-deoxy-6-sulfo-D-glucono-1,5-lactone + H(+) + NADH","pmd":2.016}
{"X":7428,"KEGG":"R11036","RHEA_ID":47899,"DIRECTION":"BI","MASTER_ID":47896,"compounds":"6-sulfo-D-quinovose + NAD(+) <=> 6-deoxy-6-sulfo-D-glucono-1,5-lactone + H(+) + NADH","pmd":422.107}
{"X":7429,"KEGG":"R11037","RHEA_ID":45335,"DIRECTION":"BI","MASTER_ID":45332,"metacyc":"RXN-16480","compounds":"7,8-dihydroneopterin + O2 <=> 7,8-dihydroxanthopterin + formate + glycolaldehyde + H(+)","pmd":74.037}
{"X":7430,"KEGG":"R11038","RHEA_ID":43567,"DIRECTION":"BI","MASTER_ID":43564,"compounds":"4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + L-alanine <=> [5-(aminomethyl)-3-furyl]methyl phosphate + pyruvate","pmd":1.032}
{"X":7431,"KEGG":"R11039","RHEA_ID":47839,"DIRECTION":"BI","MASTER_ID":47836,"compounds":"[5-(aminomethyl)-3-furyl]methyl phosphate + ATP <=> [5-(aminomethyl)furan-3-yl]methyl diphosphate + ADP","pmd":79.966}
{"X":7432,"KEGG":"R11040","RHEA_ID":47843,"DIRECTION":"BI","MASTER_ID":47840,"compounds":"[5-(aminomethyl)furan-3-yl]methyl diphosphate + gamma-L-glutamyltyramine <=> (4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine + diphosphate","pmd":88.183}
{"X":7433,"KEGG":"R11040","RHEA_ID":47843,"DIRECTION":"BI","MASTER_ID":47840,"compounds":"[5-(aminomethyl)furan-3-yl]methyl diphosphate + gamma-L-glutamyltyramine <=> (4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine + diphosphate","pmd":109.053}
{"X":7434,"KEGG":"R11043","RHEA_ID":25859,"DIRECTION":"BI","MASTER_ID":25856,"compounds":"(9Z)-octadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z)-octadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":7435,"KEGG":"R11044","RHEA_ID":45099,"DIRECTION":"BI","MASTER_ID":45096,"compounds":"(9Z)-hexadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z)-hexadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":7436,"KEGG":"R11048","RHEA_ID":46979,"DIRECTION":"BI","MASTER_ID":46976,"compounds":"(S)-6-hydroxynicotine + O2 <=> 6-hydroxy-N-methylmyosmine + H2O2","pmd":2.016}
{"X":7437,"KEGG":"R11048","RHEA_ID":46999,"DIRECTION":"BI","MASTER_ID":46996,"compounds":"6-hydroxy-N-methylmyosmine + H2O <=> 6-hydroxypseudooxynicotine","pmd":2.016}
{"X":7438,"KEGG":"R11050","RHEA_ID":46991,"DIRECTION":"BI","MASTER_ID":46988,"compounds":"(R)-6-hydroxynicotine + O2 <=> 6-hydroxy-N-methylmyosmine + H2O2","pmd":2.016}
{"X":7439,"KEGG":"R11052","RHEA_ID":36046,"DIRECTION":"BI","MASTER_ID":36043,"compounds":"all-trans-8'-apo-beta-carotenal + O2 <=> 13-apo-beta-carotenone + 2,6-dimethyldeca-2,4,6,8-tetraenedial","pmd":158.11}
{"X":7440,"KEGG":"R11053","RHEA_ID":46503,"DIRECTION":"BI","MASTER_ID":46500,"compounds":"2-oxoglutarate + O2 + UMP <=> CO2 + phosphate + succinate + uridine-5'-aldehyde","pmd":27.995}
{"X":7441,"KEGG":"R11053","RHEA_ID":46503,"DIRECTION":"BI","MASTER_ID":46500,"compounds":"2-oxoglutarate + O2 + UMP <=> CO2 + phosphate + succinate + uridine-5'-aldehyde","pmd":81.982}
{"X":7442,"KEGG":"R11054","RHEA_ID":45087,"DIRECTION":"BI","MASTER_ID":45084,"compounds":"dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 7-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":7443,"KEGG":"R11055","RHEA_ID":24223,"DIRECTION":"BI","MASTER_ID":24220,"compounds":"beta-myrcene + O2 + reduced [NADPH--hemoprotein reductase] <=> (4R)-ipsdienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":7444,"KEGG":"R11056","RHEA_ID":48011,"DIRECTION":"BI","MASTER_ID":48008,"compounds":"2-hydroxybenzoyl-CoA + H(+) + NADH + O2 <=> 2,5-dihydroxybenzoyl-CoA + H2O + NAD(+)","pmd":238.006}
{"X":7445,"KEGG":"R11056","RHEA_ID":48011,"DIRECTION":"BI","MASTER_ID":48008,"compounds":"2-hydroxybenzoyl-CoA + H(+) + NADH + O2 <=> 2,5-dihydroxybenzoyl-CoA + H2O + NAD(+)","pmd":15.995}
{"X":7446,"KEGG":"R11057","RHEA_ID":42163,"DIRECTION":"BI","MASTER_ID":42160,"compounds":"(11Z,14Z)-eicosadienoyl-CoA + AH2 + O2 <=> (5Z,11Z,14Z)-eicosatrienoyl-CoA + A + 2 H2O"}
{"X":7447,"KEGG":"R11058","RHEA_ID":42167,"DIRECTION":"BI","MASTER_ID":42164,"compounds":"(11Z,14Z,17Z)-eicosatrienoyl-CoA + AH2 + O2 <=> (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + A + 2 H2O"}
{"X":7448,"KEGG":"R11060","RHEA_ID":46423,"DIRECTION":"BI","MASTER_ID":46420,"compounds":"(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":7449,"KEGG":"R11061","RHEA_ID":47747,"DIRECTION":"BI","MASTER_ID":47744,"compounds":"demethylphylloquinone + H(+) + NADPH <=> demethylphylloquinol + NADP(+)","pmd":2.016}
{"X":7450,"KEGG":"R11061","RHEA_ID":47747,"DIRECTION":"BI","MASTER_ID":47744,"compounds":"demethylphylloquinone + H(+) + NADPH <=> demethylphylloquinol + NADP(+)","pmd":306.741}
{"X":7451,"KEGG":"R11063","RHEA_ID":26340,"DIRECTION":"BI","MASTER_ID":26337,"compounds":"L-homocysteine + S-methyl-L-methionine <=> H(+) + 2 L-methionine","pmd":15.024}
{"X":7452,"KEGG":"R11063","RHEA_ID":26340,"DIRECTION":"BI","MASTER_ID":26337,"compounds":"L-homocysteine + S-methyl-L-methionine <=> H(+) + 2 L-methionine","pmd":14.016}
{"X":7453,"KEGG":"R11064","RHEA_ID":44335,"DIRECTION":"BI","MASTER_ID":44332,"compounds":"ATP + L-alanine + L-anticapsin <=> ADP + bacilysin + H(+) + phosphate","pmd":79.966}
{"X":7454,"KEGG":"R11064","RHEA_ID":44335,"DIRECTION":"BI","MASTER_ID":44332,"compounds":"ATP + L-alanine + L-anticapsin <=> ADP + bacilysin + H(+) + phosphate","pmd":71.037}
{"X":7455,"KEGG":"R11065","RHEA_ID":33822,"DIRECTION":"BI","MASTER_ID":33819,"compounds":"3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate <=> 3-[(1E,4R)-4-hydroxycyclohex-2-en-1-ylidene]pyruvate","pmd":0}
{"X":7456,"KEGG":"R11070","RHEA_ID":46923,"DIRECTION":"BI","MASTER_ID":46920,"metacyc":"RXN-803","compounds":"H(+) + trans-cinnamate <=> CO2 + styrene","pmd":43.99}
{"X":7457,"KEGG":"R11071","RHEA_ID":33810,"DIRECTION":"BI","MASTER_ID":33807,"metacyc":"RXN-801","compounds":"H(+) + trans-ferulate <=> 2-methoxy-4-vinylphenol + CO2","pmd":43.99}
{"X":7458,"KEGG":"R11072","RHEA_ID":45139,"DIRECTION":"BI","MASTER_ID":45136,"compounds":"2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate <=> 7,8-dihydroneopterin 3'-phosphate + H2O","pmd":18.01}
{"X":7459,"KEGG":"R11073","RHEA_ID":45331,"DIRECTION":"BI","MASTER_ID":45328,"ecocyc":"RXN-10856","metacyc":"RXN-10856","compounds":"7,8-dihydroneopterin <=> 7,8-dihydromonapterin","pmd":0}
{"X":7460,"KEGG":"R11074","RHEA_ID":46279,"DIRECTION":"BI","MASTER_ID":46276,"compounds":"(S)-malate + H(+) <=> (S)-lactate + CO2"}
{"X":7461,"KEGG":"R11075","RHEA_ID":44031,"DIRECTION":"BI","MASTER_ID":44028,"metacyc":"RXN-16224","compounds":"L-altrarate <=> 5-dehydro-4-deoxy-D-glucarate + H2O","pmd":18.011}
{"X":7462,"KEGG":"R11076","RHEA_ID":46927,"DIRECTION":"BI","MASTER_ID":46924,"compounds":"(R)-2-hydroxy-4-methylpentanoyl-CoA <=> 4-methylpent-2-enoyl-CoA + H2O","pmd":18.011}
{"X":7463,"KEGG":"R11077","RHEA_ID":45811,"DIRECTION":"BI","MASTER_ID":45808,"metacyc":"RXN-16458","compounds":"galactarate <=> (2S,3R)-dihydroxy-5-oxohexanedioate + H2O","pmd":18.011}
{"X":7464,"KEGG":"R11078","RHEA_ID":45563,"DIRECTION":"BI","MASTER_ID":45560,"metacyc":"RXN-16430","compounds":"L-isoleucine <=> D-allo-isoleucine","pmd":0}
{"X":7465,"KEGG":"R11079","RHEA_ID":45567,"DIRECTION":"BI","MASTER_ID":45564,"compounds":"2-epi-5-epi-valiolone <=> 5-epi-valiolone","pmd":0}
{"X":7466,"KEGG":"R11080","RHEA_ID":46931,"DIRECTION":"BI","MASTER_ID":46928,"compounds":"a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol <=> a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol"}
{"X":7467,"KEGG":"R11081","RHEA_ID":46935,"DIRECTION":"BI","MASTER_ID":46932,"metacyc":"RXN-16712","compounds":"2-epi-5-epi-valiolone 7-phosphate <=> 5-epi-valiolone 7-phosphate","pmd":0}
{"X":7468,"KEGG":"R11083","RHEA_ID":45607,"DIRECTION":"BI","MASTER_ID":45604,"compounds":"D-glucaro-1,4-lactone <=> 5-dehydro-4-deoxy-D-glucarate + H(+)","pmd":0}
{"X":7469,"KEGG":"R11084","RHEA_ID":45627,"DIRECTION":"BI","MASTER_ID":45624,"metacyc":"RXN-16278","compounds":"ATP + holo-[CmaA peptidyl-carrier protein] + L-alloisoleucine <=> AMP + diphosphate + L-alloisoleucyl-[CmaA peptidyl-carrier protein]","pmd":215.969}
{"X":7470,"KEGG":"R11084","RHEA_ID":45627,"DIRECTION":"BI","MASTER_ID":45624,"metacyc":"RXN-16278","compounds":"ATP + holo-[CmaA peptidyl-carrier protein] + L-alloisoleucine <=> AMP + diphosphate + L-alloisoleucyl-[CmaA peptidyl-carrier protein]","pmd":159.933}
{"X":7471,"KEGG":"R11085","RHEA_ID":44339,"DIRECTION":"BI","MASTER_ID":44336,"metacyc":"RXN-16295","compounds":"an L-alpha-amino acid + ATP + L-arginine <=> ADP + H(+) + L-arginyl-L-alpha-amino acid + phosphate","pmd":252.918}
{"X":7472,"KEGG":"R11085","RHEA_ID":44339,"DIRECTION":"BI","MASTER_ID":44336,"metacyc":"RXN-16295","compounds":"an L-alpha-amino acid + ATP + L-arginine <=> ADP + H(+) + L-arginyl-L-alpha-amino acid + phosphate","pmd":79.966}
{"X":7473,"KEGG":"R11098","RHEA_ID":39978,"DIRECTION":"BI","MASTER_ID":39975,"compounds":"2-iminobutanoate + H2O <=> 2-oxobutanoate + NH4(+)","pmd":0.984}
{"X":7474,"KEGG":"R11099","RHEA_ID":40674,"DIRECTION":"BI","MASTER_ID":40671,"compounds":"2-iminopropanoate + H2O <=> NH4(+) + pyruvate"}
{"X":7475,"KEGG":"R11100","RHEA_ID":40670,"DIRECTION":"BI","MASTER_ID":40667,"compounds":"2-aminoprop-2-enoate <=> 2-iminopropanoate"}
{"X":7476,"KEGG":"R11101","RHEA_ID":39970,"DIRECTION":"BI","MASTER_ID":39967,"compounds":"2-aminobut-2-enoate <=> 2-iminobutanoate","pmd":0}
{"X":7477,"KEGG":"R11104","RHEA_ID":48871,"DIRECTION":"BI","MASTER_ID":48868,"compounds":"H2O + NADH <=> AMP + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide","pmd":318.062}
{"X":7478,"KEGG":"R11105","RHEA_ID":50955,"DIRECTION":"BI","MASTER_ID":50952,"compounds":"7-chloro-L-tryptophan + AH2 + O2 <=> A + CO2 + 2 H2O + monodechloroaminopyrrolnitrin","pmd":46.006}
{"X":7479,"KEGG":"R11108","RHEA_ID":38046,"DIRECTION":"BI","MASTER_ID":38043,"compounds":"2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (4Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":7480,"KEGG":"R11109","RHEA_ID":46419,"DIRECTION":"BI","MASTER_ID":46416,"compounds":"2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (6Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":7481,"KEGG":"R11125","RHEA_ID":42843,"DIRECTION":"BI","MASTER_ID":42840,"compounds":"acetyl-CoA + 6 H(+) + 5 malonyl-CoA + 2 NADPH <=> 2-hydroxy-5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 3 H2O + 2 NADP(+)","pmd":22.024}
{"X":7482,"KEGG":"R11125","RHEA_ID":42843,"DIRECTION":"BI","MASTER_ID":42840,"compounds":"acetyl-CoA + 6 H(+) + 5 malonyl-CoA + 2 NADPH <=> 2-hydroxy-5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 3 H2O + 2 NADP(+)","pmd":42.011}
{"X":7483,"KEGG":"R11125","RHEA_ID":42843,"DIRECTION":"BI","MASTER_ID":42840,"compounds":"acetyl-CoA + 6 H(+) + 5 malonyl-CoA + 2 NADPH <=> 2-hydroxy-5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 3 H2O + 2 NADP(+)","pmd":86}
{"X":7484,"KEGG":"R11126","RHEA_ID":43067,"DIRECTION":"BI","MASTER_ID":43064,"compounds":"(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + monacolin J carboxylate <=> holo-[2-methylbutanoate polyketide synthase] + lovastatin carboxylate","pmd":84.058}
{"X":7485,"KEGG":"R11127","RHEA_ID":43063,"DIRECTION":"BI","MASTER_ID":43060,"metacyc":"RXN-15619","compounds":"2-O-(alpha-D-glucopyranosyl)glycerol + phosphate <=> beta-D-glucose 1-phosphate + glycerol","pmd":5.929}
{"X":7486,"KEGG":"R11132","RHEA_ID":49119,"DIRECTION":"BI","MASTER_ID":49116,"compounds":"H(+) + NADPH + O2 + protodeoxyviolaceinate <=> deoxyviolaceinate + H2O + NADP(+)","pmd":387.98}
{"X":7487,"KEGG":"R11132","RHEA_ID":49119,"DIRECTION":"BI","MASTER_ID":49116,"compounds":"H(+) + NADPH + O2 + protodeoxyviolaceinate <=> deoxyviolaceinate + H2O + NADP(+)","pmd":15.995}
{"X":7488,"KEGG":"R11133","RHEA_ID":49747,"DIRECTION":"BI","MASTER_ID":49744,"compounds":"deoxyviolaceinate + H(+) + O2 <=> CO2 + deoxyviolacein + H2O","pmd":30.011}
{"X":7489,"KEGG":"R11134","RHEA_ID":49127,"DIRECTION":"BI","MASTER_ID":49124,"compounds":"H(+) + NADPH + O2 + protodeoxyviolaceinate <=> H2O + NADP(+) + protoviolaceinate","pmd":15.995}
{"X":7490,"KEGG":"R11134","RHEA_ID":49127,"DIRECTION":"BI","MASTER_ID":49124,"compounds":"H(+) + NADPH + O2 + protodeoxyviolaceinate <=> H2O + NADP(+) + protoviolaceinate","pmd":387.98}
{"X":7491,"KEGG":"R11135","RHEA_ID":49123,"DIRECTION":"BI","MASTER_ID":49120,"compounds":"H(+) + NADPH + O2 + protoviolaceinate <=> H2O + NADP(+) + violaceinate","pmd":15.995}
{"X":7492,"KEGG":"R11135","RHEA_ID":49123,"DIRECTION":"BI","MASTER_ID":49120,"compounds":"H(+) + NADPH + O2 + protoviolaceinate <=> H2O + NADP(+) + violaceinate","pmd":371.985}
{"X":7493,"KEGG":"R11136","RHEA_ID":49735,"DIRECTION":"BI","MASTER_ID":49732,"compounds":"H(+) + O2 + violaceinate <=> CO2 + H2O + violacein","pmd":30.011}
{"X":7494,"KEGG":"R11141","RHEA_ID":42835,"DIRECTION":"BI","MASTER_ID":42832,"compounds":"(2E)-octenal + H(+) + pyruvate <=> (S)-3-acetyloctanal + CO2","pmd":44.026}
{"X":7495,"KEGG":"R11142","RHEA_ID":34634,"DIRECTION":"BI","MASTER_ID":34631,"compounds":"5beta-cholestane-3alpha,7alpha,12alpha-triol + 5 H(+) + 3 O2 + 6 reduced [adrenodoxin] <=> (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + 4 H2O + 6 oxidized [adrenodoxin]","pmd":29.974}
{"X":7496,"KEGG":"R11143","RHEA_ID":49291,"DIRECTION":"BI","MASTER_ID":49288,"compounds":"(R)-lipoate + [lipoyl-carrier protein]-L-lysine + ATP <=> [lipoyl-carrier protein]-(R)-N(6)-lipoyl-L-lysine + AMP + diphosphate + H(+)","pmd":141.02}
{"X":7497,"KEGG":"R11143","RHEA_ID":49291,"DIRECTION":"BI","MASTER_ID":49288,"compounds":"(R)-lipoate + [lipoyl-carrier protein]-L-lysine + ATP <=> [lipoyl-carrier protein]-(R)-N(6)-lipoyl-L-lysine + AMP + diphosphate + H(+)","pmd":159.933}
{"X":7498,"KEGG":"R11145","RHEA_ID":47499,"DIRECTION":"BI","MASTER_ID":47496,"compounds":"lithocholate + NADP(+) <=> 3-oxo-5beta-cholan-24-oate + H(+) + NADPH","pmd":2.016}
{"X":7499,"KEGG":"R11145","RHEA_ID":47499,"DIRECTION":"BI","MASTER_ID":47496,"compounds":"lithocholate + NADP(+) <=> 3-oxo-5beta-cholan-24-oate + H(+) + NADPH","pmd":369.801}
{"X":7500,"KEGG":"R11146","RHEA_ID":47523,"DIRECTION":"BI","MASTER_ID":47520,"metacyc":"RXN-17395","compounds":"3-oxo-5beta-cholan-24-oate + H(+) + NADPH <=> isolithocholate + NADP(+)","pmd":2.016}
{"X":7501,"KEGG":"R11146","RHEA_ID":47523,"DIRECTION":"BI","MASTER_ID":47520,"metacyc":"RXN-17395","compounds":"3-oxo-5beta-cholan-24-oate + H(+) + NADPH <=> isolithocholate + NADP(+)","pmd":369.801}
{"X":7502,"KEGG":"R11147","RHEA_ID":48731,"DIRECTION":"BI","MASTER_ID":48728,"compounds":"3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NAD(+) <=> 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H(+) + NADH","pmd":268.871}
{"X":7503,"KEGG":"R11147","RHEA_ID":48731,"DIRECTION":"BI","MASTER_ID":48728,"compounds":"3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NAD(+) <=> 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H(+) + NADH","pmd":2.016}
{"X":7504,"KEGG":"R11148","RHEA_ID":48723,"DIRECTION":"BI","MASTER_ID":48720,"metacyc":"RXN-17420","compounds":"aurachin B + H2O + NAD(+) <=> 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NADH","pmd":18.011}
{"X":7505,"KEGG":"R11148","RHEA_ID":48727,"DIRECTION":"BI","MASTER_ID":48724,"compounds":"aurachin B + H(+) + H2O <=> 3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide","pmd":18.011}
{"X":7506,"KEGG":"R11151","RHEA_ID":48991,"DIRECTION":"BI","MASTER_ID":48988,"metacyc":"RXN-17329","compounds":"NADH + O2 + rifampicin <=> 2'-N-hydroxyrifampicin + H2O + NAD(+)","pmd":15.995}
{"X":7507,"KEGG":"R11151","RHEA_ID":48991,"DIRECTION":"BI","MASTER_ID":48988,"metacyc":"RXN-17329","compounds":"NADH + O2 + rifampicin <=> 2'-N-hydroxyrifampicin + H2O + NAD(+)","pmd":173.275}
{"X":7508,"KEGG":"R11152","RHEA_ID":46599,"DIRECTION":"BI","MASTER_ID":46596,"metacyc":"RXN-17329","compounds":"NADPH + O2 + rifampicin <=> 2'-N-hydroxyrifampicin + H2O + NADP(+)","pmd":93.309}
{"X":7509,"KEGG":"R11152","RHEA_ID":46599,"DIRECTION":"BI","MASTER_ID":46596,"metacyc":"RXN-17329","compounds":"NADPH + O2 + rifampicin <=> 2'-N-hydroxyrifampicin + H2O + NADP(+)","pmd":15.995}
{"X":7510,"KEGG":"R11153","RHEA_ID":48995,"DIRECTION":"BI","MASTER_ID":48992,"compounds":"1,3,7-trimethylurate + H(+) + NADH + O2 <=> 1,3,7-trimethyl-5-hydroxyisourate + H2O + NAD(+)","pmd":439.055}
{"X":7511,"KEGG":"R11153","RHEA_ID":48995,"DIRECTION":"BI","MASTER_ID":48992,"compounds":"1,3,7-trimethylurate + H(+) + NADH + O2 <=> 1,3,7-trimethyl-5-hydroxyisourate + H2O + NAD(+)","pmd":15.995}
{"X":7512,"KEGG":"R11154","RHEA_ID":44135,"DIRECTION":"BI","MASTER_ID":44132,"metacyc":"RXN-15866","compounds":"2 S-adenosyl 3-(methylsulfanyl)propylamine + spermidine <=> 2 H(+) + N(4)-bis(aminopropyl)spermidine + 2 S-methyl-5'-thioadenosine","pmd":58.066}
{"X":7513,"KEGG":"R11154","RHEA_ID":44135,"DIRECTION":"BI","MASTER_ID":44132,"metacyc":"RXN-15866","compounds":"2 S-adenosyl 3-(methylsulfanyl)propylamine + spermidine <=> 2 H(+) + N(4)-bis(aminopropyl)spermidine + 2 S-methyl-5'-thioadenosine","pmd":115.124}
{"X":7514,"KEGG":"R11155","RHEA_ID":49047,"DIRECTION":"BI","MASTER_ID":49044,"compounds":"H(+) + NADH + O2 + protoasukamycin <=> 4-hydroxyprotoasukamycin + H2O + NAD(+)","pmd":15.995}
{"X":7515,"KEGG":"R11155","RHEA_ID":49047,"DIRECTION":"BI","MASTER_ID":49044,"compounds":"H(+) + NADH + O2 + protoasukamycin <=> 4-hydroxyprotoasukamycin + H2O + NAD(+)","pmd":134.883}
{"X":7516,"KEGG":"R11156","RHEA_ID":49055,"DIRECTION":"BI","MASTER_ID":49052,"compounds":"asperlicin C + H(+) + NADH + O2 <=> asperlicin E + H2O + NAD(+)","pmd":242.987}
{"X":7517,"KEGG":"R11156","RHEA_ID":49055,"DIRECTION":"BI","MASTER_ID":49052,"compounds":"asperlicin C + H(+) + NADH + O2 <=> asperlicin E + H2O + NAD(+)","pmd":15.995}
{"X":7518,"KEGG":"R11157","RHEA_ID":49059,"DIRECTION":"BI","MASTER_ID":49056,"compounds":"asperlicin C + H(+) + NADPH + O2 <=> asperlicin E + H2O + NADP(+)","pmd":15.995}
{"X":7519,"KEGG":"R11157","RHEA_ID":49059,"DIRECTION":"BI","MASTER_ID":49056,"compounds":"asperlicin C + H(+) + NADPH + O2 <=> asperlicin E + H2O + NADP(+)","pmd":322.953}
{"X":7520,"KEGG":"R11158","RHEA_ID":49375,"DIRECTION":"BI","MASTER_ID":49372,"compounds":"H(+) + NADH + O2 + protodeoxyviolaceinate <=> H2O + NAD(+) + protoviolaceinate","pmd":308.014}
{"X":7521,"KEGG":"R11158","RHEA_ID":49375,"DIRECTION":"BI","MASTER_ID":49372,"compounds":"H(+) + NADH + O2 + protodeoxyviolaceinate <=> H2O + NAD(+) + protoviolaceinate","pmd":15.995}
{"X":7522,"KEGG":"R11159","RHEA_ID":42879,"DIRECTION":"BI","MASTER_ID":42876,"metacyc":"RXN-15864","compounds":"S-adenosyl 3-(methylsulfanyl)propylamine + spermidine <=> H(+) + N(4)-aminopropylspermidine + S-methyl-5'-thioadenosine","pmd":58.066}
{"X":7523,"KEGG":"R11159","RHEA_ID":42879,"DIRECTION":"BI","MASTER_ID":42876,"metacyc":"RXN-15864","compounds":"S-adenosyl 3-(methylsulfanyl)propylamine + spermidine <=> H(+) + N(4)-aminopropylspermidine + S-methyl-5'-thioadenosine","pmd":57.058}
{"X":7524,"KEGG":"R11160","RHEA_ID":42875,"DIRECTION":"BI","MASTER_ID":42872,"metacyc":"RXN-15865","compounds":"N(4)-aminopropylspermidine + S-adenosyl 3-(methylsulfanyl)propylamine <=> H(+) + N(4)-bis(aminopropyl)spermidine + S-methyl-5'-thioadenosine","pmd":58.066}
{"X":7525,"KEGG":"R11161","RHEA_ID":49079,"DIRECTION":"BI","MASTER_ID":49076,"compounds":"dibenzothiophene + FMNH2 + O2 <=> dibenzothiophene 5-oxide + FMN + H(+) + H2O","pmd":15.995}
{"X":7526,"KEGG":"R11161","RHEA_ID":49079,"DIRECTION":"BI","MASTER_ID":49076,"compounds":"dibenzothiophene + FMNH2 + O2 <=> dibenzothiophene 5-oxide + FMN + H(+) + H2O","pmd":2.016}
{"X":7527,"KEGG":"R11162","RHEA_ID":49083,"DIRECTION":"BI","MASTER_ID":49080,"compounds":"dibenzothiophene 5-oxide + FMNH2 + O2 <=> dibenzothiophene 5,5-dioxide + FMN + H(+) + H2O","pmd":15.995}
{"X":7528,"KEGG":"R11162","RHEA_ID":49083,"DIRECTION":"BI","MASTER_ID":49080,"compounds":"dibenzothiophene 5-oxide + FMNH2 + O2 <=> dibenzothiophene 5,5-dioxide + FMN + H(+) + H2O","pmd":2.016}
{"X":7529,"KEGG":"R11163","RHEA_ID":49075,"DIRECTION":"BI","MASTER_ID":49072,"compounds":"dibenzothiophene + 2 FMNH2 + 2 O2 <=> dibenzothiophene 5,5-dioxide + 2 FMN + 2 H(+) + 2 H2O","pmd":31.99}
{"X":7530,"KEGG":"R11163","RHEA_ID":49075,"DIRECTION":"BI","MASTER_ID":49072,"compounds":"dibenzothiophene + 2 FMNH2 + 2 O2 <=> dibenzothiophene 5,5-dioxide + 2 FMN + 2 H(+) + 2 H2O","pmd":2.016}
{"X":7531,"KEGG":"R11164","RHEA_ID":12315,"DIRECTION":"BI","MASTER_ID":12312,"compounds":"dibenzothiophene 5,5-dioxide + FMNH2 + NADH + O2 <=> 2'-hydroxybiphenyl-2-sulfinate + FMN + H(+) + H2O + NAD(+)","pmd":2.016}
{"X":7532,"KEGG":"R11164","RHEA_ID":12315,"DIRECTION":"BI","MASTER_ID":12312,"compounds":"dibenzothiophene 5,5-dioxide + FMNH2 + NADH + O2 <=> 2'-hydroxybiphenyl-2-sulfinate + FMN + H(+) + H2O + NAD(+)","pmd":18.011}
{"X":7533,"KEGG":"R11164","RHEA_ID":12315,"DIRECTION":"BI","MASTER_ID":12312,"compounds":"dibenzothiophene 5,5-dioxide + FMNH2 + NADH + O2 <=> 2'-hydroxybiphenyl-2-sulfinate + FMN + H(+) + H2O + NAD(+)","pmd":209.02}
{"X":7534,"KEGG":"R11168","RHEA_ID":48883,"DIRECTION":"BI","MASTER_ID":48880,"compounds":"a quinone + CO + H2O <=> a quinol + CO2"}
{"X":7535,"KEGG":"R11169","RHEA_ID":33310,"DIRECTION":"BI","MASTER_ID":33307,"compounds":"(2R)-2-O-(alpha-D-mannosyl)-glycerate(out) + N(pros)-phospho-L-histidyl-[protein] <=> (2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate(in) + L-histidyl-[protein]","pmd":79.966}
{"X":7536,"KEGG":"R11170","RHEA_ID":33426,"DIRECTION":"BI","MASTER_ID":33423,"compounds":"N(pros)-phospho-L-histidyl-[protein] + N,N'-diacetylchitobiose(out) <=> diacetylchitobiose-6'-phosphate(in) + L-histidyl-[protein]","pmd":79.966}
{"X":7537,"KEGG":"R11172","RHEA_ID":49295,"DIRECTION":"BI","MASTER_ID":49292,"compounds":"D-cellobiose(out) + N(pros)-phospho-L-histidyl-[protein] <=> 6-phospho-beta-D-glucosyl-(1->4)-D-glucose(in) + L-histidyl-[protein]","pmd":79.966}
{"X":7538,"KEGG":"R11181","RHEA_ID":43235,"DIRECTION":"BI","MASTER_ID":43232,"compounds":"H2O + isatin <=> H(+) + isatinate","pmd":18.011}
{"X":7539,"KEGG":"R11182","RHEA_ID":44739,"DIRECTION":"BI","MASTER_ID":44736,"compounds":"acetyl-CoA + dihydroxyacetone phosphate <=> 3-hydroxy-2,4-pentanedione 5-phosphate + CoA","pmd":42.011}
{"X":7540,"KEGG":"R11183","RHEA_ID":15380,"DIRECTION":"BI","MASTER_ID":15377,"compounds":"(S)-4,5-dihydroxypentane-2,3-dione + ATP <=> (S)-4-hydroxy-2,3-pentanedione-5-phosphate + ADP + H(+)","pmd":79.966}
{"X":7541,"KEGG":"R11184","RHEA_ID":45127,"DIRECTION":"BI","MASTER_ID":45124,"metacyc":"RXN-16280","compounds":"acarbose + ATP <=> acarbose 7(IV)-phosphate + ADP + H(+)","pmd":79.966}
{"X":7542,"KEGG":"R11186","RHEA_ID":45471,"DIRECTION":"BI","MASTER_ID":45468,"compounds":"alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + di-trans,octa-cis-undecaprenyl diphosphate <=> (Kdo)2-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate","pmd":79.966}
{"X":7543,"KEGG":"R11187","RHEA_ID":11595,"DIRECTION":"BI","MASTER_ID":11592,"compounds":"dihydromonacolin L-[lovastatin nonaketide synthase] + H2O <=> dihydromonacolin L carboxylate + H(+) + holo-[lovastatin nonaketide synthase]"}
{"X":7544,"KEGG":"R11188","RHEA_ID":43535,"DIRECTION":"BI","MASTER_ID":43532,"compounds":"a ribonucleoside 3',5'-bisphosphate + H2O <=> a ribonucleoside 5'-phosphate + phosphate"}
{"X":7545,"KEGG":"R11189","RHEA_ID":44639,"DIRECTION":"BI","MASTER_ID":44636,"compounds":"2,4-dinitroanisole + H2O <=> 2,4-dinitrophenol + H(+) + methanol","pmd":14.016}
{"X":7546,"KEGG":"R11191","RHEA_ID":45107,"DIRECTION":"BI","MASTER_ID":45104,"compounds":"6-demethylmitomycin A + S-adenosyl-L-methionine <=> mitomycin A + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7547,"KEGG":"R11192","RHEA_ID":45103,"DIRECTION":"BI","MASTER_ID":45100,"compounds":"6-demethylmitomycin B + S-adenosyl-L-methionine <=> mitomycin B + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7548,"KEGG":"R11193","RHEA_ID":46807,"DIRECTION":"BI","MASTER_ID":46804,"compounds":"a (4E,8E)-4-sphinga-4,8-dienine ceramide + S-adenosyl-L-methionine <=> a 9-methyl-(4E,8E)-sphinga-4,8-dienine ceramide + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7549,"KEGG":"R11200","RHEA_ID":45183,"DIRECTION":"BI","MASTER_ID":45180,"metacyc":"RXN-16473","compounds":"2 (E)-4-coumaroyl-CoA + spermidine <=> 2 CoA + 2 H(+) + N(1),N(8)-bis(coumaroyl)-spermidine","pmd":292.074}
{"X":7550,"KEGG":"R11200","RHEA_ID":45183,"DIRECTION":"BI","MASTER_ID":45180,"metacyc":"RXN-16473","compounds":"2 (E)-4-coumaroyl-CoA + spermidine <=> 2 CoA + 2 H(+) + N(1),N(8)-bis(coumaroyl)-spermidine","pmd":146.037}
{"X":7551,"KEGG":"R11201","RHEA_ID":45339,"DIRECTION":"BI","MASTER_ID":45336,"compounds":"(9Z)-hexadecenoyl-CoA + [Wnt protein]-L-serine <=> [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + CoA"}
{"X":7552,"KEGG":"R11202","RHEA_ID":45343,"DIRECTION":"BI","MASTER_ID":45340,"metacyc":"RXN-16482","compounds":"[Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + H2O <=> (9Z)-hexadecenoate + [Wnt protein]-L-serine + H(+)"}
{"X":7553,"KEGG":"R11203","RHEA_ID":46295,"DIRECTION":"BI","MASTER_ID":46292,"metacyc":"RXN-15515","compounds":"a 5'-end triphospho-(purine-ribonucleotide) in mRNA + GDP + H(+) <=> a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + diphosphate"}
{"X":7554,"KEGG":"R11204","RHEA_ID":24701,"DIRECTION":"BI","MASTER_ID":24698,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A <=> 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + a 1,2-diacyl-sn-glycerol"}
{"X":7555,"KEGG":"R11205","RHEA_ID":46911,"DIRECTION":"BI","MASTER_ID":46908,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA <=> 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + a 1,2-diacyl-sn-glycerol"}
{"X":7556,"KEGG":"R11206","RHEA_ID":38030,"DIRECTION":"BI","MASTER_ID":38027,"compounds":"(E)-caffeate + hydrocaffeoyl-CoA <=> (E)-caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)propanoate","pmd":2.016}
{"X":7557,"KEGG":"R11209","RHEA_ID":47955,"DIRECTION":"BI","MASTER_ID":47952,"metacyc":"RXN-16706","compounds":"[prokaryotic ubiquitin-like protein]-C-terminal-L-glutamine + H2O <=> [prokaryotic ubiquitin-like protein]-C-terminal-L-glutamate + NH4(+)"}
{"X":7558,"KEGG":"R11210","RHEA_ID":48747,"DIRECTION":"BI","MASTER_ID":48744,"compounds":"(-)-yatein + 2-oxoglutarate + O2 <=> (-)-deoxypodophyllotoxin + CO2 + H2O + succinate","pmd":27.995}
{"X":7559,"KEGG":"R11210","RHEA_ID":48747,"DIRECTION":"BI","MASTER_ID":48744,"compounds":"(-)-yatein + 2-oxoglutarate + O2 <=> (-)-deoxypodophyllotoxin + CO2 + H2O + succinate","pmd":2.016}
{"X":7560,"KEGG":"R11211","RHEA_ID":49031,"DIRECTION":"BI","MASTER_ID":49028,"compounds":"(-)-bursehernin + O2 + reduced [NADPH--hemoprotein reductase] <=> (-)-5'-demethylyatein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":7561,"KEGG":"R11212","RHEA_ID":49035,"DIRECTION":"BI","MASTER_ID":49032,"compounds":"(-)-4'-desmethyl-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase] <=> 4'-demethylepipodophyllotoxin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":7562,"KEGG":"R11214","RHEA_ID":47915,"DIRECTION":"BI","MASTER_ID":47912,"compounds":"6-deoxy-6-sulfo-D-gluconate <=> 2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate + H2O","pmd":18.011}
{"X":7563,"KEGG":"R11215","RHEA_ID":38658,"DIRECTION":"BI","MASTER_ID":38655,"metacyc":"RXN-16963","compounds":"6-tuliposide B <=> D-glucose + tulipalin B","pmd":114.032}
{"X":7564,"KEGG":"R11216","RHEA_ID":48103,"DIRECTION":"BI","MASTER_ID":48100,"compounds":"L-arginyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7565,"KEGG":"R11217","RHEA_ID":48107,"DIRECTION":"BI","MASTER_ID":48104,"compounds":"N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7566,"KEGG":"R11218","RHEA_ID":48115,"DIRECTION":"BI","MASTER_ID":48112,"metacyc":"RXN-16892","compounds":"N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7567,"KEGG":"R11219","RHEA_ID":48099,"DIRECTION":"BI","MASTER_ID":48096,"metacyc":"RXN-17121","compounds":"L-arginyl-[protein] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7568,"KEGG":"R11220","RHEA_ID":48111,"DIRECTION":"BI","MASTER_ID":48108,"metacyc":"RXN-17120","compounds":"L-arginyl-[protein] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7569,"KEGG":"R11221","RHEA_ID":48119,"DIRECTION":"BI","MASTER_ID":48116,"compounds":"L-arginyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(5)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7570,"KEGG":"R11222","RHEA_ID":49087,"DIRECTION":"BI","MASTER_ID":49084,"compounds":"(-)-matairesinol + O2 + reduced [NADPH--hemoprotein reductase] <=> (-)-pluviatolide + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]","pmd":2.016}
{"X":7571,"KEGG":"R11224","RHEA_ID":47599,"DIRECTION":"BI","MASTER_ID":47596,"metacyc":"RXN-16903","compounds":"an archaeal dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate <=> an archaeal dolichyl 3-O-(2,3-diacetamido-2,3-dideoxy- beta-D-glucuronosyl)-N-acetyl- alpha-D-glucosaminyl phosphate + H(+) + UDP","pmd":258.085}
{"X":7572,"KEGG":"R11225","RHEA_ID":37746,"DIRECTION":"BI","MASTER_ID":37743,"compounds":"dimethylallyl phosphate + FMNH2 <=> phosphate + prenyl-FMNH2","pmd":68.063}
{"X":7573,"KEGG":"R11225","RHEA_ID":37746,"DIRECTION":"BI","MASTER_ID":37743,"compounds":"dimethylallyl phosphate + FMNH2 <=> phosphate + prenyl-FMNH2","pmd":360.143}
{"X":7574,"KEGG":"R11226","RHEA_ID":41359,"DIRECTION":"BI","MASTER_ID":41356,"compounds":"bacteriochlorophyll a + 3 NADP(+) <=> geranylgeranyl-bacteriochlorophyllide a + 3 H(+) + 3 NADPH","pmd":160.416}
{"X":7575,"KEGG":"R11226","RHEA_ID":41359,"DIRECTION":"BI","MASTER_ID":41356,"compounds":"bacteriochlorophyll a + 3 NADP(+) <=> geranylgeranyl-bacteriochlorophyllide a + 3 H(+) + 3 NADPH","pmd":6.047}
{"X":7576,"KEGG":"R11227","RHEA_ID":48163,"DIRECTION":"BI","MASTER_ID":48160,"compounds":"3 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin] <=> epoxypheophorbide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]","pmd":15.995}
{"X":7577,"KEGG":"R11228","RHEA_ID":48167,"DIRECTION":"BI","MASTER_ID":48164,"compounds":"epoxypheophorbide a + H2O <=> H(+) + red chlorophyll catabolite","pmd":18.011}
{"X":7578,"KEGG":"R11229","RHEA_ID":48875,"DIRECTION":"BI","MASTER_ID":48872,"metacyc":"RXN-16729","compounds":"a gentamycin + GTP <=> a gentamycin 2''-phosphate + GDP + H(+)","pmd":79.966}
{"X":7579,"KEGG":"R11230","RHEA_ID":49039,"DIRECTION":"BI","MASTER_ID":49036,"compounds":"(-)-pluviatolide + S-adenosyl-L-methionine <=> (-)-bursehernin + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7580,"KEGG":"R11231","RHEA_ID":49479,"DIRECTION":"BI","MASTER_ID":49476,"compounds":"2 H2O + L-1-piperideine-6-carboxylate + NAD(+) <=> H(+) + L-2-aminoadipate + NADH","pmd":34.006}
{"X":7581,"KEGG":"R11231","RHEA_ID":49479,"DIRECTION":"BI","MASTER_ID":49476,"compounds":"2 H2O + L-1-piperideine-6-carboxylate + NAD(+) <=> H(+) + L-2-aminoadipate + NADH","pmd":503.048}
{"X":7582,"KEGG":"R11232","RHEA_ID":49483,"DIRECTION":"BI","MASTER_ID":49480,"compounds":"2 H2O + L-1-piperideine-6-carboxylate + NADP(+) <=> H(+) + L-2-aminoadipate + NADPH","pmd":583.014}
{"X":7583,"KEGG":"R11232","RHEA_ID":49483,"DIRECTION":"BI","MASTER_ID":49480,"compounds":"2 H2O + L-1-piperideine-6-carboxylate + NADP(+) <=> H(+) + L-2-aminoadipate + NADPH","pmd":34.006}
{"X":7584,"KEGG":"R11234","RHEA_ID":49423,"DIRECTION":"BI","MASTER_ID":49420,"compounds":"ATP + valienone <=> ADP + H(+) + valienone 7-phosphate","pmd":79.966}
{"X":7585,"KEGG":"R11241","RHEA_ID":49391,"DIRECTION":"BI","MASTER_ID":49388,"compounds":"UDP-alpha-D-glucose + validoxylamine A <=> H(+) + UDP + validamycin A","pmd":68.844}
{"X":7586,"KEGG":"R11242","RHEA_ID":47911,"DIRECTION":"BI","MASTER_ID":47908,"compounds":"6-deoxy-6-sulfo-D-glucono-1,5-lactone + H2O <=> 6-deoxy-6-sulfo-D-gluconate + H(+)","pmd":18.011}
{"X":7587,"KEGG":"R11257","RHEA_ID":47959,"DIRECTION":"BI","MASTER_ID":47956,"compounds":"3-maleylpyruvate + H2O <=> H(+) + maleate + pyruvate","pmd":70.005}
{"X":7588,"KEGG":"R11258","RHEA_ID":47967,"DIRECTION":"BI","MASTER_ID":47964,"compounds":"H2O + N(pros)-phospho-L-histidyl-[protein] <=> L-histidyl-[protein] + phosphate"}
{"X":7589,"KEGG":"R11259","RHEA_ID":47963,"DIRECTION":"BI","MASTER_ID":47960,"compounds":"H2O + N(tele)-phospho-L-histidyl-[protein] <=> L-histidyl-[protein] + phosphate"}
{"X":7590,"KEGG":"R11312","RHEA_ID":47847,"DIRECTION":"BI","MASTER_ID":47844,"compounds":"2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) <=> CO2 + diphosphate + thiamine phosphate","pmd":78.082}
{"X":7591,"KEGG":"R11312","RHEA_ID":47847,"DIRECTION":"BI","MASTER_ID":47844,"compounds":"2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) <=> CO2 + diphosphate + thiamine phosphate","pmd":46.071}
{"X":7592,"KEGG":"R11324","RHEA_ID":49067,"DIRECTION":"BI","MASTER_ID":49064,"compounds":"2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol <=> calcitetrol + H2O + 2 oxidized [adrenodoxin]","pmd":15.995}
{"X":7593,"KEGG":"R11325","RHEA_ID":40530,"DIRECTION":"BI","MASTER_ID":40527,"compounds":"2 a ubiquinol + 4 H(+)(in) + O2(in) <=> 2 a ubiquinone + 4 H(+)(out) + 2 H2O(in)"}
{"X":7594,"KEGG":"R11327","RHEA_ID":49567,"DIRECTION":"BI","MASTER_ID":49564,"compounds":"D-sedoheptulose 7-phosphate <=> 2-epi-valiolone + phosphate","pmd":97.977}
{"X":7595,"KEGG":"R11328","RHEA_ID":41262,"DIRECTION":"BI","MASTER_ID":41259,"compounds":"L-tryptophan <=> (E)-3-(indol-3-yl)acrylate + NH4(+)","pmd":17.027}
{"X":7596,"KEGG":"R11329","RHEA_ID":49575,"DIRECTION":"BI","MASTER_ID":49572,"compounds":"Fe-coproporphyrin III + 2 H(+) <=> coproporphyrin III + Fe(2+)","pmd":53.919}
{"X":7597,"KEGG":"R11330","RHEA_ID":49587,"DIRECTION":"BI","MASTER_ID":49584,"metacyc":"RXN-17771","compounds":"D-erythrulose 1-phosphate <=> L-erythrulose 1-phosphate","pmd":0}
{"X":7598,"KEGG":"R11332","RHEA_ID":49591,"DIRECTION":"BI","MASTER_ID":49588,"metacyc":"RXN-17762","compounds":"L-erythrulose 1-phosphate <=> D-erythrulose 4-phosphate","pmd":0}
{"X":7599,"KEGG":"R11333","RHEA_ID":48787,"DIRECTION":"BI","MASTER_ID":48784,"metacyc":"RXN-17762","compounds":"D-erythrulose 4-phosphate <=> D-erythrose 4-phosphate","pmd":0}
{"X":7600,"KEGG":"R11334","RHEA_ID":49595,"DIRECTION":"BI","MASTER_ID":49592,"metacyc":"RXN-17605","compounds":"2-hydroxyisobutanoyl-CoA <=> (3S)-hydroxybutanoyl-CoA","pmd":0}
{"X":7601,"KEGG":"R11336","RHEA_ID":10179,"DIRECTION":"BI","MASTER_ID":10176,"compounds":"(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD(+) <=> (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + NADH","pmd":447.043}
{"X":7602,"KEGG":"R11336","RHEA_ID":10179,"DIRECTION":"BI","MASTER_ID":10176,"compounds":"(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD(+) <=> (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + NADH","pmd":2.016}
{"X":7603,"KEGG":"R11337","RHEA_ID":49615,"DIRECTION":"BI","MASTER_ID":49612,"ecocyc":"KETOGLUTREDUCT-RXN","metacyc":"KETOGLUTREDUCT-RXN","compounds":"(R)-2-hydroxyglutarate + NAD(+) <=> 2-oxoglutarate + H(+) + NADH","pmd":2.016}
{"X":7604,"KEGG":"R11337","RHEA_ID":49615,"DIRECTION":"BI","MASTER_ID":49612,"ecocyc":"KETOGLUTREDUCT-RXN","metacyc":"KETOGLUTREDUCT-RXN","compounds":"(R)-2-hydroxyglutarate + NAD(+) <=> 2-oxoglutarate + H(+) + NADH","pmd":518.095}
{"X":7605,"KEGG":"R11338","RHEA_ID":23555,"DIRECTION":"BI","MASTER_ID":23552,"compounds":"2-methylpropane-1,2-diol + NAD(+) <=> 2-hydroxy-2-methylpropanal + H(+) + NADH"}
{"X":7606,"KEGG":"R11339","RHEA_ID":36502,"DIRECTION":"BI","MASTER_ID":36499,"compounds":"2-dehydro-3-deoxy-L-rhamnonate + NAD(+) <=> 2,4-didehydro-3-deoxy-L-rhamnonate + H(+) + NADH","pmd":2.016}
{"X":7607,"KEGG":"R11339","RHEA_ID":36502,"DIRECTION":"BI","MASTER_ID":36499,"compounds":"2-dehydro-3-deoxy-L-rhamnonate + NAD(+) <=> 2,4-didehydro-3-deoxy-L-rhamnonate + H(+) + NADH","pmd":504.08}
{"X":7608,"KEGG":"R11340","RHEA_ID":48755,"DIRECTION":"BI","MASTER_ID":48752,"compounds":"2-oxoglutarate + O2 + validamycin A <=> CO2 + H(+) + succinate + validamycin B","pmd":15.995}
{"X":7609,"KEGG":"R11340","RHEA_ID":48755,"DIRECTION":"BI","MASTER_ID":48752,"compounds":"2-oxoglutarate + O2 + validamycin A <=> CO2 + H(+) + succinate + validamycin B","pmd":27.995}
{"X":7610,"KEGG":"R11341","RHEA_ID":49623,"DIRECTION":"BI","MASTER_ID":49620,"compounds":"D-erythritol 1-phosphate + NADP(+) <=> D-erythrulose 1-phosphate + H(+) + NADPH","pmd":544.075}
{"X":7611,"KEGG":"R11341","RHEA_ID":49623,"DIRECTION":"BI","MASTER_ID":49620,"compounds":"D-erythritol 1-phosphate + NADP(+) <=> D-erythrulose 1-phosphate + H(+) + NADPH","pmd":2.016}
{"X":7612,"KEGG":"R11343","RHEA_ID":43435,"DIRECTION":"BI","MASTER_ID":43432,"compounds":"2 [Fe(III)cytochrome c] + butan-1-ol <=> 2 [Fe(II)cytochrome c] + butanal + 2 H(+)"}
{"X":7613,"KEGG":"R11346","RHEA_ID":48979,"DIRECTION":"BI","MASTER_ID":48976,"compounds":"5-methyl-phenazine-1-carboxylate + 2 H(+) + NADH + O2 <=> CO2 + H2O + NAD(+) + pyocyanin","pmd":455.046}
{"X":7614,"KEGG":"R11346","RHEA_ID":48979,"DIRECTION":"BI","MASTER_ID":48976,"compounds":"5-methyl-phenazine-1-carboxylate + 2 H(+) + NADH + O2 <=> CO2 + H2O + NAD(+) + pyocyanin","pmd":29.003}
{"X":7615,"KEGG":"R11347","RHEA_ID":49687,"DIRECTION":"BI","MASTER_ID":49684,"compounds":"H(+) + NADH + O2 + resorcinol <=> benzene-1,2,4-triol + H2O + NAD(+)","pmd":539.093}
{"X":7616,"KEGG":"R11347","RHEA_ID":49687,"DIRECTION":"BI","MASTER_ID":49684,"compounds":"H(+) + NADH + O2 + resorcinol <=> benzene-1,2,4-triol + H2O + NAD(+)","pmd":15.995}
{"X":7617,"KEGG":"R11348","RHEA_ID":50231,"DIRECTION":"BI","MASTER_ID":50228,"compounds":"FADH2 + O2 + resorcinol <=> benzene-1,2,4-triol + FAD + H(+) + H2O","pmd":2.016}
{"X":7618,"KEGG":"R11348","RHEA_ID":50231,"DIRECTION":"BI","MASTER_ID":50228,"compounds":"FADH2 + O2 + resorcinol <=> benzene-1,2,4-triol + FAD + H(+) + H2O","pmd":15.995}
{"X":7619,"KEGG":"R11349","RHEA_ID":50343,"DIRECTION":"BI","MASTER_ID":50340,"compounds":"2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + testosterone <=> 1alpha-hydroxytestosterone + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]","pmd":15.995}
{"X":7620,"KEGG":"R11350","RHEA_ID":49619,"DIRECTION":"BI","MASTER_ID":49616,"compounds":"2-hydroxy-2-methylpropanal + H2O + NAD(+) <=> 2-hydroxy-2-methylpropanoate + 2 H(+) + NADH","pmd":560.07}
{"X":7621,"KEGG":"R11351","RHEA_ID":33442,"DIRECTION":"BI","MASTER_ID":33439,"compounds":"glyoxal + H2O + O2 <=> glyoxylate + H(+) + H2O2"}
{"X":7622,"KEGG":"R11352","RHEA_ID":49639,"DIRECTION":"BI","MASTER_ID":49636,"compounds":"H2O + methylglyoxal + O2 <=> H(+) + H2O2 + pyruvate"}
{"X":7623,"KEGG":"R11353","RHEA_ID":49467,"DIRECTION":"BI","MASTER_ID":49464,"metacyc":"RXN-17555","compounds":"2,6-dihydroxybenzoate + H(+) <=> CO2 + resorcinol","pmd":43.99}
{"X":7624,"KEGG":"R11355","RHEA_ID":51571,"DIRECTION":"BI","MASTER_ID":51568,"compounds":"(25S)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (25S)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]","pmd":2.016}
{"X":7625,"KEGG":"R11356","RHEA_ID":51575,"DIRECTION":"BI","MASTER_ID":51572,"compounds":"(25S)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (25S)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]","pmd":15.995}
{"X":7626,"KEGG":"R11357","RHEA_ID":51567,"DIRECTION":"BI","MASTER_ID":51564,"compounds":"cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> (25S)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]","pmd":29.974}
{"X":7627,"KEGG":"R11358","RHEA_ID":43915,"DIRECTION":"BI","MASTER_ID":43912,"compounds":"cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (25R)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]","pmd":15.995}
{"X":7628,"KEGG":"R11359","RHEA_ID":43919,"DIRECTION":"BI","MASTER_ID":43916,"compounds":"(25R)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (25R)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]","pmd":2.016}
{"X":7629,"KEGG":"R11360","RHEA_ID":43923,"DIRECTION":"BI","MASTER_ID":43920,"compounds":"(25R)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (25R)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]","pmd":15.995}
{"X":7630,"KEGG":"R11361","RHEA_ID":49999,"DIRECTION":"BI","MASTER_ID":49996,"compounds":"cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> (25R)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]","pmd":29.974}
{"X":7631,"KEGG":"R11372","RHEA_ID":49583,"DIRECTION":"BI","MASTER_ID":49580,"compounds":"(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate <=> cyclic pyranopterin phosphate + diphosphate","pmd":159.933}
{"X":7632,"KEGG":"R11373","RHEA_ID":49655,"DIRECTION":"BI","MASTER_ID":49652,"compounds":"H(+) + NADH + O2 + protoviolaceinate <=> H2O + NAD(+) + violaceinate","pmd":292.019}
{"X":7633,"KEGG":"R11373","RHEA_ID":49655,"DIRECTION":"BI","MASTER_ID":49652,"compounds":"H(+) + NADH + O2 + protoviolaceinate <=> H2O + NAD(+) + violaceinate","pmd":15.995}
{"X":7634,"KEGG":"R11374","RHEA_ID":49671,"DIRECTION":"BI","MASTER_ID":49668,"compounds":"H(+) + NADH + O2 + protodeoxyviolaceinate <=> deoxyviolaceinate + H2O + NAD(+)","pmd":15.995}
{"X":7635,"KEGG":"R11374","RHEA_ID":49671,"DIRECTION":"BI","MASTER_ID":49668,"compounds":"H(+) + NADH + O2 + protodeoxyviolaceinate <=> deoxyviolaceinate + H2O + NAD(+)","pmd":308.014}
{"X":7636,"KEGG":"R11376","RHEA_ID":56187,"DIRECTION":"BI","MASTER_ID":56184,"compounds":"globoside Gb4Cer + UDP-alpha-D-galactose <=> globoside NOR1 + H(+) + UDP"}
{"X":7637,"KEGG":"R11377","RHEA_ID":43591,"DIRECTION":"BI","MASTER_ID":43588,"compounds":"globoside NORint + UDP-alpha-D-galactose <=> globoside NOR2 + H(+) + UDP"}
{"X":7638,"KEGG":"R11379","RHEA_ID":55599,"DIRECTION":"BI","MASTER_ID":55596,"compounds":"globoside NOR1 + UDP-N-acetyl-alpha-D-galactosamine <=> globoside NORint + H(+) + UDP"}
{"X":7639,"KEGG":"R11380","RHEA_ID":50363,"DIRECTION":"BI","MASTER_ID":50360,"compounds":"(R)-mandelonitrile + O2 <=> benzoyl cyanide + H2O2","pmd":2.016}
{"X":7640,"KEGG":"R11382","RHEA_ID":49003,"DIRECTION":"BI","MASTER_ID":49000,"compounds":"aurachin C + H(+) + NADH + O2 <=> 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NAD(+)","pmd":269.879}
{"X":7641,"KEGG":"R11382","RHEA_ID":49003,"DIRECTION":"BI","MASTER_ID":49000,"compounds":"aurachin C + H(+) + NADH + O2 <=> 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NAD(+)","pmd":15.995}
{"X":7642,"KEGG":"R11383","RHEA_ID":49007,"DIRECTION":"BI","MASTER_ID":49004,"compounds":"aurachin C + H(+) + NADPH + O2 <=> 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NADP(+)","pmd":349.845}
{"X":7643,"KEGG":"R11383","RHEA_ID":49007,"DIRECTION":"BI","MASTER_ID":49004,"compounds":"aurachin C + H(+) + NADPH + O2 <=> 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NADP(+)","pmd":15.995}
{"X":7644,"KEGG":"R11384","RHEA_ID":49015,"DIRECTION":"BI","MASTER_ID":49012,"compounds":"aurachin C + H(+) + NADH + O2 <=> aurachin C epoxide + H2O + NAD(+)","pmd":269.879}
{"X":7645,"KEGG":"R11384","RHEA_ID":49015,"DIRECTION":"BI","MASTER_ID":49012,"compounds":"aurachin C + H(+) + NADH + O2 <=> aurachin C epoxide + H2O + NAD(+)","pmd":15.995}
{"X":7646,"KEGG":"R11385","RHEA_ID":49011,"DIRECTION":"BI","MASTER_ID":49008,"compounds":"aurachin C + H(+) + NADPH + O2 <=> aurachin C epoxide + H2O + NADP(+)","pmd":15.995}
{"X":7647,"KEGG":"R11385","RHEA_ID":49011,"DIRECTION":"BI","MASTER_ID":49008,"compounds":"aurachin C + H(+) + NADPH + O2 <=> aurachin C epoxide + H2O + NADP(+)","pmd":349.845}
{"X":7648,"KEGG":"R11394","RHEA_ID":46891,"DIRECTION":"BI","MASTER_ID":46888,"compounds":"3-deoxy-alpha-D-manno-oct-2-ulosonate + O2 <=> 3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + H2O2","pmd":2.016}
{"X":7649,"KEGG":"R11395","RHEA_ID":46895,"DIRECTION":"BI","MASTER_ID":46892,"metacyc":"RXN-16747","compounds":"2-oxoglutarate + 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate <=> 3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + L-glutamate","pmd":1.032}
{"X":7650,"KEGG":"R11397","RHEA_ID":49411,"DIRECTION":"BI","MASTER_ID":49408,"metacyc":"RXN-17502","compounds":"[(1->2)-beta-D-mannosyl](n) + phosphate <=> [(1->2)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate"}
{"X":7651,"KEGG":"R11399","RHEA_ID":53399,"DIRECTION":"BI","MASTER_ID":53396,"compounds":"dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] <=> 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + dolichyl phosphate + H(+)"}
{"X":7652,"KEGG":"R11400","RHEA_ID":52619,"DIRECTION":"BI","MASTER_ID":52616,"metacyc":"RXN-14842","compounds":"3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + ATP <=> 3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-6-O-phospho-alpha-D-mannosyl)-L-threonyl-[protein] + ADP + H(+)","pmd":79.966}
{"X":7653,"KEGG":"R11401","RHEA_ID":49091,"DIRECTION":"BI","MASTER_ID":49088,"compounds":"FAD + H(+) + H2O + squalene <=> FADH2 + hydroxysqualene","pmd":15.995}
{"X":7654,"KEGG":"R11401","RHEA_ID":49091,"DIRECTION":"BI","MASTER_ID":49088,"compounds":"FAD + H(+) + H2O + squalene <=> FADH2 + hydroxysqualene","pmd":2.016}
{"X":7655,"KEGG":"R11402","RHEA_ID":26058,"DIRECTION":"BI","MASTER_ID":26055,"compounds":"GTP + H(+) + valienol 1-phosphate <=> diphosphate + GDP-valienol","pmd":345.047}
{"X":7656,"KEGG":"R11402","RHEA_ID":26058,"DIRECTION":"BI","MASTER_ID":26055,"compounds":"GTP + H(+) + valienol 1-phosphate <=> diphosphate + GDP-valienol","pmd":78.091}
{"X":7657,"KEGG":"R11403","RHEA_ID":48867,"DIRECTION":"BI","MASTER_ID":48864,"compounds":"2-methylpropan-1-amine + FADH2 + O2 <=> FAD + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine","pmd":2.016}
{"X":7658,"KEGG":"R11404","RHEA_ID":49807,"DIRECTION":"BI","MASTER_ID":49804,"compounds":"2-methylpropan-1-amine + FMNH2 + O2 <=> FMN + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine","pmd":2.016}
{"X":7659,"KEGG":"R11405","RHEA_ID":50367,"DIRECTION":"BI","MASTER_ID":50364,"compounds":"(S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-nandinine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]","pmd":2.016}
{"X":7660,"KEGG":"R11406","RHEA_ID":49427,"DIRECTION":"BI","MASTER_ID":49424,"compounds":"ATP + validone <=> ADP + H(+) + validone 7-phosphate","pmd":79.966}
{"X":7661,"KEGG":"R11408","RHEA_ID":49507,"DIRECTION":"BI","MASTER_ID":49504,"compounds":"phosphinomethylmalate <=> phosphinomethylisomalate","pmd":0}
{"X":7662,"KEGG":"R11409","RHEA_ID":49491,"DIRECTION":"BI","MASTER_ID":49488,"metacyc":"RXN-17514","compounds":"GDP-4-dehydro-alpha-D-rhamnose + L-glutamate <=> 2-oxoglutarate + GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+)","pmd":15.995}
{"X":7663,"KEGG":"R11409","RHEA_ID":49491,"DIRECTION":"BI","MASTER_ID":49488,"metacyc":"RXN-17514","compounds":"GDP-4-dehydro-alpha-D-rhamnose + L-glutamate <=> 2-oxoglutarate + GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+)","pmd":1.032}
{"X":7664,"KEGG":"R11410","RHEA_ID":47987,"DIRECTION":"BI","MASTER_ID":47984,"compounds":"H2O + presqualene diphosphate <=> diphosphate + hydroxysqualene","pmd":159.933}
{"X":7665,"KEGG":"R11411","RHEA_ID":49571,"DIRECTION":"BI","MASTER_ID":49568,"compounds":"2-glutathionyl-2-methylbut-3-en-1-ol <=> (3R)-3,4-epoxy-3-methylbut-1-ene + glutathione","pmd":84.058}
{"X":7666,"KEGG":"R11424","RHEA_ID":49719,"DIRECTION":"BI","MASTER_ID":49716,"compounds":"3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] + H(+) + NADH + O2 <=> 3,5-dihydroxy-4-methylanthranilyl-[aryl-carrier protein] + H2O + NAD(+)"}
{"X":7667,"KEGG":"R11426","RHEA_ID":51419,"DIRECTION":"BI","MASTER_ID":51416,"compounds":"a (2S,3R)-flavan-3-ol + 2 NADP(+) <=> an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH","pmd":3.024}
{"X":7668,"KEGG":"R11426","RHEA_ID":51419,"DIRECTION":"BI","MASTER_ID":51416,"compounds":"a (2S,3R)-flavan-3-ol + 2 NADP(+) <=> an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH","pmd":521.007}
{"X":7669,"KEGG":"R11427","RHEA_ID":51423,"DIRECTION":"BI","MASTER_ID":51420,"compounds":"a (2S,3S)-flavan-3-ol + 2 NADP(+) <=> an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH","pmd":521.007}
{"X":7670,"KEGG":"R11427","RHEA_ID":51423,"DIRECTION":"BI","MASTER_ID":51420,"compounds":"a (2S,3S)-flavan-3-ol + 2 NADP(+) <=> an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH","pmd":3.024}
{"X":7671,"KEGG":"R11428","RHEA_ID":36562,"DIRECTION":"BI","MASTER_ID":36559,"compounds":"A + cis-4-hydroxy-D-proline <=> 4-hydroxy-1-pyrroline-2-carboxylate + AH2 + H(+)","pmd":2.016}
{"X":7672,"KEGG":"R11439","RHEA_ID":49203,"DIRECTION":"BI","MASTER_ID":49200,"compounds":"D-mannose 6-phosphate + H2O + phosphoenolpyruvate <=> 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + phosphate","pmd":88.016}
{"X":7673,"KEGG":"R11439","RHEA_ID":49203,"DIRECTION":"BI","MASTER_ID":49200,"compounds":"D-mannose 6-phosphate + H2O + phosphoenolpyruvate <=> 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + phosphate","pmd":180.063}
{"X":7674,"KEGG":"R11440","RHEA_ID":49219,"DIRECTION":"BI","MASTER_ID":49216,"compounds":"3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + H2O <=> 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + phosphate","pmd":79.966}
{"X":7675,"KEGG":"R11441","RHEA_ID":49223,"DIRECTION":"BI","MASTER_ID":49220,"compounds":"3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + CTP <=> CMP-beta-3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + diphosphate","pmd":90.136}
{"X":7676,"KEGG":"R11441","RHEA_ID":49223,"DIRECTION":"BI","MASTER_ID":49220,"compounds":"3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + CTP <=> CMP-beta-3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + diphosphate","pmd":305.041}
{"X":7677,"KEGG":"R11442","RHEA_ID":50727,"DIRECTION":"BI","MASTER_ID":50724,"compounds":"(E)-4-hydroxyphenylacetaldehyde oxime <=> (Z)-(4-hydroxyphenyl)acetaldehyde oxime","pmd":0}
{"X":7678,"KEGG":"R11443","RHEA_ID":12343,"DIRECTION":"BI","MASTER_ID":12340,"compounds":"L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein] <=> H(+) + N-terminal L-leucyl-L-lysyl-[protein] + tRNA(Leu)"}
{"X":7679,"KEGG":"R11444","RHEA_ID":50419,"DIRECTION":"BI","MASTER_ID":50416,"compounds":"L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] <=> H(+) + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu)"}
{"X":7680,"KEGG":"R11445","RHEA_ID":42855,"DIRECTION":"BI","MASTER_ID":42852,"compounds":"3 H(+) + holo-[2-methylbutanoate polyketide synthase] + 2 malonyl-CoA + 2 NADPH + S-adenosyl-L-methionine <=> (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CO2 + 2 CoA + H2O + 2 NADP(+) + S-adenosyl-L-homocysteine","pmd":22.024}
{"X":7681,"KEGG":"R11445","RHEA_ID":42855,"DIRECTION":"BI","MASTER_ID":42852,"compounds":"3 H(+) + holo-[2-methylbutanoate polyketide synthase] + 2 malonyl-CoA + 2 NADPH + S-adenosyl-L-methionine <=> (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CO2 + 2 CoA + H2O + 2 NADP(+) + S-adenosyl-L-homocysteine","pmd":86}
{"X":7682,"KEGG":"R11445","RHEA_ID":42855,"DIRECTION":"BI","MASTER_ID":42852,"compounds":"3 H(+) + holo-[2-methylbutanoate polyketide synthase] + 2 malonyl-CoA + 2 NADPH + S-adenosyl-L-methionine <=> (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CO2 + 2 CoA + H2O + 2 NADP(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7683,"KEGG":"R11447","RHEA_ID":50015,"DIRECTION":"BI","MASTER_ID":50012,"compounds":"H(+) + NADPH + O2 + tert-butanol <=> 2-methylpropane-1,2-diol + H2O + NADP(+)"}
{"X":7684,"KEGG":"R11448","RHEA_ID":50003,"DIRECTION":"BI","MASTER_ID":50000,"compounds":"butane + H(+) + NADH + O2 <=> butan-1-ol + H2O + NAD(+)"}
{"X":7685,"KEGG":"R11449","RHEA_ID":50007,"DIRECTION":"BI","MASTER_ID":50004,"compounds":"H(+) + NADPH + O2 + tetracycline <=> 11a-hydroxytetracycline + H2O + NADP(+)","pmd":15.995}
{"X":7686,"KEGG":"R11449","RHEA_ID":50007,"DIRECTION":"BI","MASTER_ID":50004,"compounds":"H(+) + NADPH + O2 + tetracycline <=> 11a-hydroxytetracycline + H2O + NADP(+)","pmd":284.943}
{"X":7687,"KEGG":"R11452","RHEA_ID":49155,"DIRECTION":"BI","MASTER_ID":49152,"compounds":"dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine <=> dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7688,"KEGG":"R11453","RHEA_ID":49159,"DIRECTION":"BI","MASTER_ID":49156,"compounds":"dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine <=> dTDP-alpha-D-forosamine + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7689,"KEGG":"R11454","RHEA_ID":49763,"DIRECTION":"BI","MASTER_ID":49760,"compounds":"EDTA + FMNH2 + O2 <=> ethylenediaminetriacetate + FMN + glyoxylate + 2 H(+) + H2O","pmd":58.006}
{"X":7690,"KEGG":"R11454","RHEA_ID":49763,"DIRECTION":"BI","MASTER_ID":49760,"compounds":"EDTA + FMNH2 + O2 <=> ethylenediaminetriacetate + FMN + glyoxylate + 2 H(+) + H2O","pmd":2.016}
{"X":7691,"KEGG":"R11455","RHEA_ID":49767,"DIRECTION":"BI","MASTER_ID":49764,"metacyc":"RXN-17508","compounds":"ethylenediaminetriacetate + FMNH2 + O2 <=> ethylenediaminediacetate + FMN + glyoxylate + H(+) + H2O","pmd":2.016}
{"X":7692,"KEGG":"R11455","RHEA_ID":49767,"DIRECTION":"BI","MASTER_ID":49764,"metacyc":"RXN-17508","compounds":"ethylenediaminetriacetate + FMNH2 + O2 <=> ethylenediaminediacetate + FMN + glyoxylate + H(+) + H2O","pmd":58.005}
{"X":7693,"KEGG":"R11456","RHEA_ID":40990,"DIRECTION":"BI","MASTER_ID":40987,"compounds":"EDTA + 2 FMNH2 + 2 O2 <=> ethylenediaminediacetate + 2 FMN + 2 glyoxylate + 3 H(+) + 2 H2O","pmd":2.016}
{"X":7694,"KEGG":"R11456","RHEA_ID":40990,"DIRECTION":"BI","MASTER_ID":40987,"compounds":"EDTA + 2 FMNH2 + 2 O2 <=> ethylenediaminediacetate + 2 FMN + 2 glyoxylate + 3 H(+) + 2 H2O","pmd":116.011}
{"X":7695,"KEGG":"R11457","RHEA_ID":50719,"DIRECTION":"BI","MASTER_ID":50716,"compounds":"dimethyl sulfone + FMNH2 + O2 <=> FMN + formaldehyde + 2 H(+) + H2O + methanesulfinate","pmd":2.016}
{"X":7696,"KEGG":"R11458","RHEA_ID":50699,"DIRECTION":"BI","MASTER_ID":50696,"compounds":"calciol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> calcidiol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]","pmd":15.995}
{"X":7697,"KEGG":"R11459","RHEA_ID":50703,"DIRECTION":"BI","MASTER_ID":50700,"compounds":"calcidiol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> calcitriol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]","pmd":15.995}
{"X":7698,"KEGG":"R11460","RHEA_ID":48783,"DIRECTION":"BI","MASTER_ID":48780,"compounds":"ATP + L-erythrulose <=> ADP + H(+) + L-erythrulose 1-phosphate","pmd":79.966}
{"X":7699,"KEGG":"R11462","RHEA_ID":49443,"DIRECTION":"BI","MASTER_ID":49440,"compounds":"(R)-2-hydroxy-4-methylpentanoate + 4-methylpentanoyl-CoA <=> (R)-2-hydroxy-4-methylpentanoyl-CoA + 4-methylpentanoate","pmd":15.995}
{"X":7700,"KEGG":"R11477","RHEA_ID":50371,"DIRECTION":"BI","MASTER_ID":50368,"compounds":"2-methylbutan-2-ol + H(+) + NADPH + O2 <=> 3-hydroxy-3-methylbut-1-ene + 2 H2O + NADP(+)"}
{"X":7701,"KEGG":"R11478","RHEA_ID":50715,"DIRECTION":"BI","MASTER_ID":50712,"compounds":"chloride + FADH2 + O2 + tetracycline <=> 7-chlorotetracycline + FAD + H(+) + 2 H2O","pmd":2.016}
{"X":7702,"KEGG":"R11478","RHEA_ID":50715,"DIRECTION":"BI","MASTER_ID":50712,"compounds":"chloride + FADH2 + O2 + tetracycline <=> 7-chlorotetracycline + FAD + H(+) + 2 H2O","pmd":33.961}
{"X":7703,"KEGG":"R11482","RHEA_ID":51263,"DIRECTION":"BI","MASTER_ID":51260,"compounds":"4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase] <=> (10bR,4aS)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]","pmd":2.016}
{"X":7704,"KEGG":"R11483","RHEA_ID":51267,"DIRECTION":"BI","MASTER_ID":51264,"compounds":"4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase] <=> (10bS,4aR)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]","pmd":2.016}
{"X":7705,"KEGG":"R11484","RHEA_ID":49167,"DIRECTION":"BI","MASTER_ID":49164,"compounds":"a bacteriochlorophyllide c + H2O + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide c + H(+) + L-methionine","pmd":147.035}
{"X":7706,"KEGG":"R11485","RHEA_ID":50759,"DIRECTION":"BI","MASTER_ID":50756,"compounds":"NADP(+) + reduced [flavodoxin] <=> 2 H(+) + NADPH + oxidized [flavodoxin]"}
{"X":7707,"KEGG":"R11486","RHEA_ID":50747,"DIRECTION":"BI","MASTER_ID":50744,"compounds":"2 glyphosate + O2 <=> 2 aminomethylphosphonate + 2 glyoxylate + 2 H(+)","pmd":58.006}
{"X":7708,"KEGG":"R11487","RHEA_ID":50763,"DIRECTION":"BI","MASTER_ID":50760,"compounds":"a quinone + H2O + sulfite <=> a quinol + sulfate"}
{"X":7709,"KEGG":"R11489","RHEA_ID":49891,"DIRECTION":"BI","MASTER_ID":49888,"compounds":"(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + O2 <=> (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + H2O2","pmd":2.016}
{"X":7710,"KEGG":"R11490","RHEA_ID":49895,"DIRECTION":"BI","MASTER_ID":49892,"compounds":"(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + O2 <=> (5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate + H2O2","pmd":2.016}
{"X":7711,"KEGG":"R11491","RHEA_ID":49943,"DIRECTION":"BI","MASTER_ID":49940,"compounds":"(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + O2 <=> (10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2","pmd":2.016}
{"X":7712,"KEGG":"R11492","RHEA_ID":49963,"DIRECTION":"BI","MASTER_ID":49960,"compounds":"(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + H(+) + O2 <=> 5,10-dihydrophenazine + CO2 + H2O2","pmd":2.016}
{"X":7713,"KEGG":"R11494","RHEA_ID":49099,"DIRECTION":"BI","MASTER_ID":49096,"compounds":"H2O + Mg-protoporphyrin IX 13-monomethyl ester + 3 S-adenosyl-L-methionine <=> 3,8-divinyl protochlorophyllide a + 3 5'-deoxyadenosine + 4 H(+) + 3 L-methionine","pmd":11.964}
{"X":7714,"KEGG":"R11494","RHEA_ID":49099,"DIRECTION":"BI","MASTER_ID":49096,"compounds":"H2O + Mg-protoporphyrin IX 13-monomethyl ester + 3 S-adenosyl-L-methionine <=> 3,8-divinyl protochlorophyllide a + 3 5'-deoxyadenosine + 4 H(+) + 3 L-methionine","pmd":147.035}
{"X":7715,"KEGG":"R11495","RHEA_ID":50751,"DIRECTION":"BI","MASTER_ID":50748,"compounds":"H2O + juglone <=> naphthalene-1,2,4,8-tetrol","pmd":18.011}
{"X":7716,"KEGG":"R11496","RHEA_ID":50755,"DIRECTION":"BI","MASTER_ID":50752,"compounds":"2 naphthalene-1,2,4,8-tetrol + O2 <=> 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+) + 2 H2O","pmd":2.016}
{"X":7717,"KEGG":"R11497","RHEA_ID":32122,"DIRECTION":"BI","MASTER_ID":32119,"compounds":"GDP-valienol + validamine 7-phosphate <=> GDP + H(+) + validoxylamine A 7'-phosphate","pmd":158.058}
{"X":7718,"KEGG":"R11500","RHEA_ID":54447,"DIRECTION":"BI","MASTER_ID":54444,"compounds":"a (2R,3S,4S)-leucoanthocyanidin + NADP(+) <=> a (2R,3R)-dihydroflavonol + H(+) + NADPH","pmd":504.005}
{"X":7719,"KEGG":"R11500","RHEA_ID":54447,"DIRECTION":"BI","MASTER_ID":54444,"compounds":"a (2R,3S,4S)-leucoanthocyanidin + NADP(+) <=> a (2R,3R)-dihydroflavonol + H(+) + NADPH","pmd":2.016}
{"X":7720,"KEGG":"R11501","RHEA_ID":48007,"DIRECTION":"BI","MASTER_ID":48004,"compounds":"1-(3,4-dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 <=> 3,4-dimethoxybenzaldehyde + glycolaldehyde + guaiacol + H2O","pmd":168.079}
{"X":7721,"KEGG":"R11502","RHEA_ID":30274,"DIRECTION":"BI","MASTER_ID":30271,"compounds":"2 (3,4-dimethoxyphenyl)methanol + H2O2 <=> 2 (3,4-dimethoxyphenyl)methanol radical + 2 H2O"}
{"X":7722,"KEGG":"R11503","RHEA_ID":22399,"DIRECTION":"BI","MASTER_ID":22396,"compounds":"1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 <=> glycolaldehyde + guaiacol + H2O + vanillin","pmd":168.079}
{"X":7723,"KEGG":"R11504","RHEA_ID":40398,"DIRECTION":"BI","MASTER_ID":40395,"metacyc":"RXN-16775","compounds":"1,2-dihydro-beta-NAD + H(+) + O2 <=> H2O2 + NAD(+)"}
{"X":7724,"KEGG":"R11505","RHEA_ID":47999,"DIRECTION":"BI","MASTER_ID":47996,"metacyc":"RXN-16774","compounds":"1,6-dihydro-beta-NAD + H(+) + O2 <=> H2O2 + NAD(+)"}
{"X":7725,"KEGG":"R11506","RHEA_ID":49191,"DIRECTION":"BI","MASTER_ID":49188,"compounds":"a bacteriochlorophyllide d <=> a 3-vinylbacteriochlorophyllide d + H2O"}
{"X":7726,"KEGG":"R11507","RHEA_ID":49171,"DIRECTION":"BI","MASTER_ID":49168,"compounds":"8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine <=> 8,12-diethyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7727,"KEGG":"R11508","RHEA_ID":49175,"DIRECTION":"BI","MASTER_ID":49172,"compounds":"8,12-diethyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine <=> 12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7728,"KEGG":"R11509","RHEA_ID":49179,"DIRECTION":"BI","MASTER_ID":49176,"compounds":"12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine <=> 12-ethyl-8-isobutyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7729,"KEGG":"R11514","RHEA_ID":49231,"DIRECTION":"BI","MASTER_ID":49228,"compounds":"all-trans-geranylgeranyl diphosphate + bacteriochlorophyllide a + H(+) <=> diphosphate + geranylgeranyl-bacteriochlorophyllide a","pmd":272.25}
{"X":7730,"KEGG":"R11514","RHEA_ID":49231,"DIRECTION":"BI","MASTER_ID":49228,"compounds":"all-trans-geranylgeranyl diphosphate + bacteriochlorophyllide a + H(+) <=> diphosphate + geranylgeranyl-bacteriochlorophyllide a","pmd":454.305}
{"X":7731,"KEGG":"R11516","RHEA_ID":38370,"DIRECTION":"BI","MASTER_ID":38367,"compounds":"8 H(+) + malonamoyl-[OxyC ACP] + 8 malonyl-CoA <=> 18-carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[OxyC ACP] + 8 CO2 + 8 CoA","pmd":86}
{"X":7732,"KEGG":"R11519","RHEA_ID":48899,"DIRECTION":"BI","MASTER_ID":48896,"compounds":"2 oxidized [2Fe-2S]-[ferredoxin] + protochlorophyllide a <=> 3,8-divinyl protochlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]","pmd":2.016}
{"X":7733,"KEGG":"R11520","RHEA_ID":50767,"DIRECTION":"BI","MASTER_ID":50764,"compounds":"4-amino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine <=> 4-methylamino-4-dedimethylamino-anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine","pmd":13.99}
{"X":7734,"KEGG":"R11521","RHEA_ID":50771,"DIRECTION":"BI","MASTER_ID":50768,"compounds":"4-methylamino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine <=> anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7735,"KEGG":"R11522","RHEA_ID":56519,"DIRECTION":"BI","MASTER_ID":56516,"compounds":"Fe-coproporphyrin III + 2 H(+) + 2 H2O2 <=> 2 CO2 + 4 H2O + heme b","pmd":92.011}
{"X":7736,"KEGG":"R11528","RHEA_ID":43895,"DIRECTION":"BI","MASTER_ID":43892,"compounds":"[sulfur carrier]-H + L-cysteine <=> [sulfur carrier]-SH + L-alanine"}
{"X":7737,"KEGG":"R11529","RHEA_ID":43891,"DIRECTION":"BI","MASTER_ID":43888,"ecocyc":"RXN-12587","metacyc":"RXN-12587","compounds":"[sulfur carrier]-H + [sulfur-carrier protein]-S-sulfanyl-L-cysteine <=> [sulfur carrier]-SH + [sulfur-carrier protein]-L-cysteine"}
{"X":7738,"KEGG":"R11531","RHEA_ID":48923,"DIRECTION":"BI","MASTER_ID":48920,"compounds":"ADP + bacteriochlorophyllide g + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate <=> 3,8-divinyl chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]","pmd":2.016}
{"X":7739,"KEGG":"R11531","RHEA_ID":48923,"DIRECTION":"BI","MASTER_ID":48920,"compounds":"ADP + bacteriochlorophyllide g + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate <=> 3,8-divinyl chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]","pmd":79.966}
{"X":7740,"KEGG":"R11533","RHEA_ID":49115,"DIRECTION":"BI","MASTER_ID":49112,"compounds":"phenazine-1-carboxylate + S-adenosyl-L-methionine <=> 5-methyl-phenazine-1-carboxylate + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7741,"KEGG":"R11533","RHEA_ID":49115,"DIRECTION":"BI","MASTER_ID":49112,"compounds":"phenazine-1-carboxylate + S-adenosyl-L-methionine <=> 5-methyl-phenazine-1-carboxylate + S-adenosyl-L-homocysteine","pmd":15.023}
{"X":7742,"KEGG":"R11534","RHEA_ID":24729,"DIRECTION":"BI","MASTER_ID":24726,"compounds":"N-demethylindolmycin + S-adenosyl-L-methionine <=> H(+) + indolmycin + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7743,"KEGG":"R11535","RHEA_ID":49419,"DIRECTION":"BI","MASTER_ID":49416,"compounds":"ADP + alpha-D-ribose 1-phosphate <=> alpha-D-ribose 1,5-bisphosphate + AMP + H(+)","pmd":79.966}
{"X":7744,"KEGG":"R11537","RHEA_ID":49367,"DIRECTION":"BI","MASTER_ID":49364,"compounds":"17-(4-hydroxyphenyl)heptadecanoate + ATP + H(+) <=> 17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + diphosphate","pmd":329.053}
{"X":7745,"KEGG":"R11537","RHEA_ID":49367,"DIRECTION":"BI","MASTER_ID":49364,"compounds":"17-(4-hydroxyphenyl)heptadecanoate + ATP + H(+) <=> 17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + diphosphate","pmd":184.339}
{"X":7746,"KEGG":"R11538","RHEA_ID":49371,"DIRECTION":"BI","MASTER_ID":49368,"compounds":"19-(4-hydroxyphenyl)nonadecanoate + ATP + H(+) <=> 19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + diphosphate","pmd":329.053}
{"X":7747,"KEGG":"R11538","RHEA_ID":49371,"DIRECTION":"BI","MASTER_ID":49368,"compounds":"19-(4-hydroxyphenyl)nonadecanoate + ATP + H(+) <=> 19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + diphosphate","pmd":212.37}
{"X":7748,"KEGG":"R11540","RHEA_ID":49531,"DIRECTION":"BI","MASTER_ID":49528,"compounds":"(ethylene terephthalate)(n) + H2O <=> (ethylene terephthalate)(n-1) + 4-[(2-hydroxyethoxy)carbonyl]benzoate + H(+)"}
{"X":7749,"KEGG":"R11542","RHEA_ID":49447,"DIRECTION":"BI","MASTER_ID":49444,"compounds":"(2-aminobenzoyl)acetyl-CoA + H2O <=> (2-aminobenzoyl)acetate + CoA + H(+)","pmd":161.048}
{"X":7750,"KEGG":"R11544","RHEA_ID":49451,"DIRECTION":"BI","MASTER_ID":49448,"metacyc":"RXN-17506","compounds":"beta-D-Manp-(1->2)-beta-D-Manp-(1->2)-D-Manp + H2O <=> alpha-D-mannopyranose + beta-D-mannopyranosyl-(1->2)-D-mannopyranose","pmd":162.053}
{"X":7751,"KEGG":"R11545","RHEA_ID":49043,"DIRECTION":"BI","MASTER_ID":49040,"compounds":"(-)-5'-demethylyatein + S-adenosyl-L-methionine <=> (-)-yatein + H(+) + S-adenosyl-L-homocysteine","pmd":2.015}
{"X":7752,"KEGG":"R11546","RHEA_ID":50431,"DIRECTION":"BI","MASTER_ID":50428,"compounds":"methanethiol + S-adenosyl-L-methionine <=> dimethyl sulfide + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7753,"KEGG":"R11550","RHEA_ID":57863,"DIRECTION":"BI","MASTER_ID":57860,"compounds":"(E)-6-hydroxyferuloyl-CoA <=> CoA + scopoletin","pmd":192.042}
{"X":7754,"KEGG":"R11551","RHEA_ID":47947,"DIRECTION":"BI","MASTER_ID":47944,"compounds":"(2E)-geranyl diphosphate + H2O <=> (2E)-geranyl phosphate + H(+) + phosphate","pmd":79.966}
{"X":7755,"KEGG":"R11553","RHEA_ID":50251,"DIRECTION":"BI","MASTER_ID":50248,"compounds":"ATP + D-ribose 5-phosphate + H(+) <=> ADP-D-ribose + diphosphate","pmd":52.076}
{"X":7756,"KEGG":"R11553","RHEA_ID":50251,"DIRECTION":"BI","MASTER_ID":50248,"compounds":"ATP + D-ribose 5-phosphate + H(+) <=> ADP-D-ribose + diphosphate","pmd":329.052}
{"X":7757,"KEGG":"R11554","RHEA_ID":24983,"DIRECTION":"BI","MASTER_ID":24980,"compounds":"3-hydroxy-4-methylanthranilate + ATP + H(+) <=> 3-hydroxy-4-methylanthranilyl-5'-AMP + diphosphate","pmd":10.885}
{"X":7758,"KEGG":"R11554","RHEA_ID":24983,"DIRECTION":"BI","MASTER_ID":24980,"compounds":"3-hydroxy-4-methylanthranilate + ATP + H(+) <=> 3-hydroxy-4-methylanthranilyl-5'-AMP + diphosphate","pmd":329.053}
{"X":7759,"KEGG":"R11555","RHEA_ID":46899,"DIRECTION":"BI","MASTER_ID":46896,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli) <=> a 1,2-diacyl-sn-glycerol + lipid A hexaacyl 1-(2-aminoethyl diphosphate)"}
{"X":7760,"KEGG":"R11556","RHEA_ID":46903,"DIRECTION":"BI","MASTER_ID":46900,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli) <=> a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate) (E. coli)"}
{"X":7761,"KEGG":"R11557","RHEA_ID":46907,"DIRECTION":"BI","MASTER_ID":46904,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A hexaacyl 1-(2-aminoethyl diphosphate) <=> a 1,2-diacyl-sn-glycerol + lipid A 1,4'-bis(2-aminoethyl diphosphate)"}
{"X":7762,"KEGG":"R11559","RHEA_ID":50679,"DIRECTION":"BI","MASTER_ID":50676,"compounds":"H(+) + H2O + N-terminal L-asparaginyl-[protein] <=> N-terminal L-aspartyl-[protein] + NH4(+)"}
{"X":7763,"KEGG":"R11560","RHEA_ID":50683,"DIRECTION":"BI","MASTER_ID":50680,"compounds":"H2O + N-terminal L-glutaminyl-[protein] <=> N-terminal L-glutamyl-[protein] + NH4(+)"}
{"X":7764,"KEGG":"R11561","RHEA_ID":50687,"DIRECTION":"BI","MASTER_ID":50684,"compounds":"H2O + N(5)-phenyl-L-glutamine <=> aniline + H(+) + L-glutamate","pmd":75.047}
{"X":7765,"KEGG":"R11562","RHEA_ID":49551,"DIRECTION":"BI","MASTER_ID":49548,"compounds":"H2O + N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein] <=> H(+) + L-arginyl-[protein] + lactate"}
{"X":7766,"KEGG":"R11563","RHEA_ID":49555,"DIRECTION":"BI","MASTER_ID":49552,"compounds":"H2O + N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein] <=> H(+) + L-lysyl-[protein] + lactate"}
{"X":7767,"KEGG":"R11564","RHEA_ID":49559,"DIRECTION":"BI","MASTER_ID":49556,"compounds":"H2O + S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein] <=> H(+) + L-cysteinyl-[protein] + lactate"}
{"X":7768,"KEGG":"R11565","RHEA_ID":10439,"DIRECTION":"BI","MASTER_ID":10436,"compounds":"7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA <=> 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O"}
{"X":7769,"KEGG":"R11570","RHEA_ID":49907,"DIRECTION":"BI","MASTER_ID":49904,"compounds":"(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + H(+) + O2 <=> (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + CO2 + H2O2","pmd":46.005}
{"X":7770,"KEGG":"R11571","RHEA_ID":49947,"DIRECTION":"BI","MASTER_ID":49944,"metacyc":"RXN-17692","compounds":"(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate <=> (1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate","pmd":0}
{"X":7771,"KEGG":"R11573","RHEA_ID":49967,"DIRECTION":"BI","MASTER_ID":49964,"compounds":"5,10-dihydrophenazine + O2 <=> H2O2 + phenazine","pmd":2.016}
{"X":7772,"KEGG":"R11574","RHEA_ID":49899,"DIRECTION":"BI","MASTER_ID":49896,"metacyc":"RXN-12020","compounds":"(5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate <=> 5,10-dihydrophenazine-1,6-dicarboxylate","pmd":0}
{"X":7773,"KEGG":"R11575","RHEA_ID":49903,"DIRECTION":"BI","MASTER_ID":49900,"compounds":"5,10-dihydrophenazine-1,6-dicarboxylate + O2 <=> H2O2 + phenazine-1,6-dicarboxylate","pmd":2.016}
{"X":7774,"KEGG":"R11576","RHEA_ID":49955,"DIRECTION":"BI","MASTER_ID":49952,"compounds":"(10aS)-10,10a-dihydrophenazine-1-carboxylate <=> 5,10-dihydrophenazine 1-carboxylate","pmd":0}
{"X":7775,"KEGG":"R11577","RHEA_ID":49959,"DIRECTION":"BI","MASTER_ID":49956,"compounds":"5,10-dihydrophenazine 1-carboxylate + O2 <=> H2O2 + phenazine-1-carboxylate","pmd":2.016}
{"X":7776,"KEGG":"R11578","RHEA_ID":53871,"DIRECTION":"BI","MASTER_ID":53868,"metacyc":"RXN-17175","compounds":"2 H(+) + NADH + O2 + phenazine-1-carboxylate <=> 1-hydroxyphenazine + CO2 + H2O + NAD(+)","pmd":469.061}
{"X":7777,"KEGG":"R11578","RHEA_ID":53871,"DIRECTION":"BI","MASTER_ID":53868,"metacyc":"RXN-17175","compounds":"2 H(+) + NADH + O2 + phenazine-1-carboxylate <=> 1-hydroxyphenazine + CO2 + H2O + NAD(+)","pmd":27.995}
{"X":7778,"KEGG":"R11579","RHEA_ID":50235,"DIRECTION":"BI","MASTER_ID":50232,"compounds":"8 H(+) + heme b + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> biliverdin IXalpha + CO + Fe(2+) + 3 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]","pmd":33.929}
{"X":7779,"KEGG":"R11583","RHEA_ID":42639,"DIRECTION":"BI","MASTER_ID":42636,"compounds":"AH2 + L-cysteine + Mo-molybdopterin <=> A + H2O + L-alanine + thio-Mo-molybdopterin","pmd":417.849}
{"X":7780,"KEGG":"R11583","RHEA_ID":42639,"DIRECTION":"BI","MASTER_ID":42636,"compounds":"AH2 + L-cysteine + Mo-molybdopterin <=> A + H2O + L-alanine + thio-Mo-molybdopterin","pmd":15.977}
{"X":7781,"KEGG":"R11585","RHEA_ID":51891,"DIRECTION":"BI","MASTER_ID":51888,"compounds":"2,3,5,6-tetrachlorohydroquinone + H(+) + NAD(+) <=> 2,3,5,6-tetrachloro-1,4-benzoquinone + NADH","pmd":2.016}
{"X":7782,"KEGG":"R11585","RHEA_ID":51891,"DIRECTION":"BI","MASTER_ID":51888,"compounds":"2,3,5,6-tetrachlorohydroquinone + H(+) + NAD(+) <=> 2,3,5,6-tetrachloro-1,4-benzoquinone + NADH","pmd":420.252}
{"X":7783,"KEGG":"R11586","RHEA_ID":50479,"DIRECTION":"BI","MASTER_ID":50476,"compounds":"anthraniloyl-CoA + L-cysteinyl-[PqsD protein] <=> CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein]","pmd":119.037}
{"X":7784,"KEGG":"R11587","RHEA_ID":38546,"DIRECTION":"BI","MASTER_ID":38543,"compounds":"H(+) + malonyl-CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein] <=> (2-aminobenzoyl)acetyl-CoA + CO2 + L-cysteinyl-[PqsD protein]","pmd":75.047}
{"X":7785,"KEGG":"R11588","RHEA_ID":50475,"DIRECTION":"BI","MASTER_ID":50472,"compounds":"anthraniloyl-CoA + H(+) + malonyl-CoA <=> (2-aminobenzoyl)acetyl-CoA + CO2 + CoA","pmd":42.011}
{"X":7786,"KEGG":"R11588","RHEA_ID":50475,"DIRECTION":"BI","MASTER_ID":50472,"compounds":"anthraniloyl-CoA + H(+) + malonyl-CoA <=> (2-aminobenzoyl)acetyl-CoA + CO2 + CoA","pmd":75.047}
{"X":7787,"KEGG":"R11589","RHEA_ID":50407,"DIRECTION":"BI","MASTER_ID":50404,"compounds":"(2-aminobenzoyl)acetate + H(+) + S-octanoyl-L-cysteinyl-[PqsC protein] <=> 1-(2-aminophenyl)decane-1,3-dione + CO2 + L-cysteinyl-[PqsC protein]","pmd":82.115}
{"X":7788,"KEGG":"R11590","RHEA_ID":50411,"DIRECTION":"BI","MASTER_ID":50408,"compounds":"1-(2-aminophenyl)decane-1,3-dione <=> 2-heptyl-4(1H)-quinolone + H2O","pmd":18.011}
{"X":7789,"KEGG":"R11591","RHEA_ID":51471,"DIRECTION":"BI","MASTER_ID":51468,"compounds":"(R)-lactate + a quinone <=> a quinol + pyruvate"}
{"X":7790,"KEGG":"R11592","RHEA_ID":51479,"DIRECTION":"BI","MASTER_ID":51476,"compounds":"a ribonucleoside 5'-triphosphate + formate + H(+) <=> a 2'-deoxyribonucleoside 5'-triphosphate + CO2 + H2O"}
{"X":7791,"KEGG":"R11595","RHEA_ID":51523,"DIRECTION":"BI","MASTER_ID":51520,"compounds":"(S)-reticuline + S-adenosyl-L-methionine <=> (S)-tembetarine + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7792,"KEGG":"R11595","RHEA_ID":51523,"DIRECTION":"BI","MASTER_ID":51520,"compounds":"(S)-reticuline + S-adenosyl-L-methionine <=> (S)-tembetarine + H(+) + S-adenosyl-L-homocysteine","pmd":15.024}
{"X":7793,"KEGG":"R11597","RHEA_ID":28425,"DIRECTION":"BI","MASTER_ID":28422,"compounds":"(1E,2S)-2-methylbutanal oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-2-methylbutanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":7794,"KEGG":"R11598","RHEA_ID":51955,"DIRECTION":"BI","MASTER_ID":51952,"compounds":"(E)-2-methylpropanal oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-2-methylpropanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":7795,"KEGG":"R11601","RHEA_ID":50671,"DIRECTION":"BI","MASTER_ID":50668,"compounds":"a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose <=> an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP + H(+)","pmd":146.058}
{"X":7796,"KEGG":"R11602","RHEA_ID":51863,"DIRECTION":"BI","MASTER_ID":51860,"compounds":"(2E)-geranyl diphosphate + umbelliferone <=> 8-geranylumbelliferone + diphosphate","pmd":15.911}
{"X":7797,"KEGG":"R11602","RHEA_ID":51863,"DIRECTION":"BI","MASTER_ID":51860,"compounds":"(2E)-geranyl diphosphate + umbelliferone <=> 8-geranylumbelliferone + diphosphate","pmd":136.125}
{"X":7798,"KEGG":"R11603","RHEA_ID":51867,"DIRECTION":"BI","MASTER_ID":51864,"compounds":"(2E)-geranyl diphosphate + esculetin <=> 8-geranylesculetin + diphosphate","pmd":0.083}
{"X":7799,"KEGG":"R11603","RHEA_ID":51867,"DIRECTION":"BI","MASTER_ID":51864,"compounds":"(2E)-geranyl diphosphate + esculetin <=> 8-geranylesculetin + diphosphate","pmd":136.125}
{"X":7800,"KEGG":"R11604","RHEA_ID":51407,"DIRECTION":"BI","MASTER_ID":51404,"compounds":"H2O + L-arginine + O2 <=> 5-guanidino-2-oxopentanoate + H2O2 + NH4(+)","pmd":1.032}
{"X":7801,"KEGG":"R11606","RHEA_ID":51935,"DIRECTION":"BI","MASTER_ID":51932,"compounds":"2 [Fe(III)-cytochrome c3] + hydrogen sulfide + sulfite <=> 2 [Fe(II)-cytochrome c3] + thiosulfate"}
{"X":7802,"KEGG":"R11607","RHEA_ID":50939,"DIRECTION":"BI","MASTER_ID":50936,"metacyc":"RXN-18379","compounds":"2-oxoglutarate + 3-aminobutanoyl-CoA <=> acetoacetyl-CoA + L-glutamate","pmd":1.032}
{"X":7803,"KEGG":"R11608","RHEA_ID":46695,"DIRECTION":"BI","MASTER_ID":46692,"compounds":"4-hydroxybenzoate + ATP + H(+) <=> 4-hydroxybenzoyl-5'-AMP + diphosphate","pmd":39.911}
{"X":7804,"KEGG":"R11608","RHEA_ID":46695,"DIRECTION":"BI","MASTER_ID":46692,"compounds":"4-hydroxybenzoate + ATP + H(+) <=> 4-hydroxybenzoyl-5'-AMP + diphosphate","pmd":329.053}
{"X":7805,"KEGG":"R11609","RHEA_ID":51755,"DIRECTION":"BI","MASTER_ID":51752,"compounds":"a 2-acylphloroglucinol + dimethylallyl diphosphate <=> a 2-acyl-4-prenylphloroglucinol + diphosphate"}
{"X":7806,"KEGG":"R11610","RHEA_ID":51759,"DIRECTION":"BI","MASTER_ID":51756,"compounds":"a 2-acyl-4-prenylphloroglucinol + dimethylallyl diphosphate <=> a 2-acyl-4,6-diprenylphloroglucinol + diphosphate"}
{"X":7807,"KEGG":"R11611","RHEA_ID":51763,"DIRECTION":"BI","MASTER_ID":51760,"compounds":"a 2-acyl-4,6-diprenylphloroglucinol + dimethylallyl diphosphate <=> a 2-acyl-4,6,6-triprenylphloroglucinol + diphosphate"}
{"X":7808,"KEGG":"R11612","RHEA_ID":50883,"DIRECTION":"BI","MASTER_ID":50880,"compounds":"4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-glycerol <=> 4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)","pmd":154.003}
{"X":7809,"KEGG":"R11613","RHEA_ID":50915,"DIRECTION":"BI","MASTER_ID":50912,"compounds":"4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-L-ribitol <=> 4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)","pmd":214.024}
{"X":7810,"KEGG":"R11614","RHEA_ID":44671,"DIRECTION":"BI","MASTER_ID":44668,"compounds":"4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol <=> 4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+)","pmd":214.024}
{"X":7811,"KEGG":"R11615","RHEA_ID":50467,"DIRECTION":"BI","MASTER_ID":50464,"compounds":"4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 24 H(+) + 8 malonyl-CoA + 16 NADPH <=> 17-(4-hydroxyphenyl)heptadecanoyl-[4-hydroxyphenylalkanoate synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+)","pmd":86}
{"X":7812,"KEGG":"R11615","RHEA_ID":50467,"DIRECTION":"BI","MASTER_ID":50464,"compounds":"4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 24 H(+) + 8 malonyl-CoA + 16 NADPH <=> 17-(4-hydroxyphenyl)heptadecanoyl-[4-hydroxyphenylalkanoate synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+)","pmd":22.024}
{"X":7813,"KEGG":"R11616","RHEA_ID":50471,"DIRECTION":"BI","MASTER_ID":50468,"compounds":"4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 27 H(+) + 9 malonyl-CoA + 18 NADPH <=> 19-(4-hydroxyphenyl)nonadecanoyl-[4-hydroxyphenylalkanoate synthase] + 9 CO2 + 9 CoA + 9 H2O + 18 NADP(+)","pmd":22.024}
{"X":7814,"KEGG":"R11616","RHEA_ID":50471,"DIRECTION":"BI","MASTER_ID":50468,"compounds":"4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 27 H(+) + 9 malonyl-CoA + 18 NADPH <=> 19-(4-hydroxyphenyl)nonadecanoyl-[4-hydroxyphenylalkanoate synthase] + 9 CO2 + 9 CoA + 9 H2O + 18 NADP(+)","pmd":86}
{"X":7815,"KEGG":"R11617","RHEA_ID":51515,"DIRECTION":"BI","MASTER_ID":51512,"metacyc":"RXN-9509","compounds":"H2O + oxamate <=> NH4(+) + oxalate"}
{"X":7816,"KEGG":"R11619","RHEA_ID":22911,"DIRECTION":"BI","MASTER_ID":22908,"compounds":"3',5'-cyclic AMP + H(+) + H2O <=> 3',5'-cyclic IMP + NH4(+)","pmd":0.984}
{"X":7817,"KEGG":"R11621","RHEA_ID":13356,"DIRECTION":"BI","MASTER_ID":13353,"compounds":"4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol <=> 4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+)","pmd":214.024}
{"X":7818,"KEGG":"R11622","RHEA_ID":52031,"DIRECTION":"BI","MASTER_ID":52028,"compounds":"a jasmonyl-L-amino acid + H2O <=> a jasmonate + an L-alpha-amino acid"}
{"X":7819,"KEGG":"R11623","RHEA_ID":51715,"DIRECTION":"BI","MASTER_ID":51712,"metacyc":"RXN-18477","compounds":"keto-D-tagatose 6-phosphate <=> keto-D-fructose 6-phosphate","pmd":0}
{"X":7820,"KEGG":"R11624","RHEA_ID":51659,"DIRECTION":"BI","MASTER_ID":51656,"compounds":"keto-D-tagaturonate <=> keto-D-fructuronate","pmd":0}
{"X":7821,"KEGG":"R11625","RHEA_ID":47627,"DIRECTION":"BI","MASTER_ID":47624,"compounds":"cis-3-hydroxy-L-proline <=> 1-pyrroline-2-carboxylate + H2O","pmd":18.01}
{"X":7822,"KEGG":"R11626","RHEA_ID":52799,"DIRECTION":"BI","MASTER_ID":52796,"compounds":"2 H(+) + Ni-sirohydrochlorin <=> Ni(2+) + sirohydrochlorin","pmd":55.92}
{"X":7823,"KEGG":"R11627","RHEA_ID":52899,"DIRECTION":"BI","MASTER_ID":52896,"compounds":"2 ATP + 2 H2O + 2 L-glutamine + Ni-sirohydrochlorin <=> 2 ADP + 2 H(+) + 2 L-glutamate + Ni-sirohydrochlorin a,c-diamide + 2 phosphate","pmd":1.968}
{"X":7824,"KEGG":"R11627","RHEA_ID":52899,"DIRECTION":"BI","MASTER_ID":52896,"compounds":"2 ATP + 2 H2O + 2 L-glutamine + Ni-sirohydrochlorin <=> 2 ADP + 2 H(+) + 2 L-glutamate + Ni-sirohydrochlorin a,c-diamide + 2 phosphate","pmd":0.984}
{"X":7825,"KEGG":"R11627","RHEA_ID":52899,"DIRECTION":"BI","MASTER_ID":52896,"compounds":"2 ATP + 2 H2O + 2 L-glutamine + Ni-sirohydrochlorin <=> 2 ADP + 2 H(+) + 2 L-glutamate + Ni-sirohydrochlorin a,c-diamide + 2 phosphate","pmd":79.966}
{"X":7826,"KEGG":"R11628","RHEA_ID":52903,"DIRECTION":"BI","MASTER_ID":52900,"compounds":"3 AH2 + ATP + H2O + Ni-sirohydrochlorin a,c-diamide <=> 15,17(3)-seco-F430-17(3)-acid + 3 A + ADP + phosphate","pmd":7.055}
{"X":7827,"KEGG":"R11628","RHEA_ID":52903,"DIRECTION":"BI","MASTER_ID":52900,"compounds":"3 AH2 + ATP + H2O + Ni-sirohydrochlorin a,c-diamide <=> 15,17(3)-seco-F430-17(3)-acid + 3 A + ADP + phosphate","pmd":79.966}
{"X":7828,"KEGG":"R11629","RHEA_ID":52907,"DIRECTION":"BI","MASTER_ID":52904,"compounds":"15,17(3)-seco-F430-17(3)-acid + ATP <=> ADP + coenzyme F430 + phosphate","pmd":79.966}
{"X":7829,"KEGG":"R11629","RHEA_ID":52907,"DIRECTION":"BI","MASTER_ID":52904,"compounds":"15,17(3)-seco-F430-17(3)-acid + ATP <=> ADP + coenzyme F430 + phosphate","pmd":18.01}
{"X":7830,"KEGG":"R11631","RHEA_ID":51887,"DIRECTION":"BI","MASTER_ID":51884,"metacyc":"RXN-15941","compounds":"L-proline betaine <=> D-proline betaine","pmd":0}
{"X":7831,"KEGG":"R11632","RHEA_ID":28517,"DIRECTION":"BI","MASTER_ID":28514,"compounds":"(R)-carnitine + ATP + CoA <=> (R)-carnitinyl-CoA + AMP + diphosphate","pmd":144.103}
{"X":7832,"KEGG":"R11632","RHEA_ID":28517,"DIRECTION":"BI","MASTER_ID":28514,"compounds":"(R)-carnitine + ATP + CoA <=> (R)-carnitinyl-CoA + AMP + diphosphate","pmd":159.933}
{"X":7833,"KEGG":"R11632","RHEA_ID":28517,"DIRECTION":"BI","MASTER_ID":28514,"compounds":"(R)-carnitine + ATP + CoA <=> (R)-carnitinyl-CoA + AMP + diphosphate","pmd":185.958}
{"X":7834,"KEGG":"R11633","RHEA_ID":51627,"DIRECTION":"BI","MASTER_ID":51624,"compounds":"formate + GTP + H(+) <=> CO2 + dGTP + H2O","pmd":15.995}
{"X":7835,"KEGG":"R11634","RHEA_ID":51619,"DIRECTION":"BI","MASTER_ID":51616,"compounds":"ATP + formate + H(+) <=> CO2 + dATP + H2O","pmd":15.995}
{"X":7836,"KEGG":"R11635","RHEA_ID":51631,"DIRECTION":"BI","MASTER_ID":51628,"compounds":"formate + H(+) + UTP <=> CO2 + dUTP + H2O","pmd":15.995}
{"X":7837,"KEGG":"R11636","RHEA_ID":51623,"DIRECTION":"BI","MASTER_ID":51620,"compounds":"CTP + formate + H(+) <=> CO2 + dCTP + H2O","pmd":15.995}
{"X":7838,"KEGG":"R11637","RHEA_ID":51691,"DIRECTION":"BI","MASTER_ID":51688,"metacyc":"RXN-18467","compounds":"galactitol + NAD(+) <=> H(+) + keto-L-tagatose + NADH","pmd":484.053}
{"X":7839,"KEGG":"R11637","RHEA_ID":51691,"DIRECTION":"BI","MASTER_ID":51688,"metacyc":"RXN-18467","compounds":"galactitol + NAD(+) <=> H(+) + keto-L-tagatose + NADH","pmd":2.016}
{"X":7840,"KEGG":"R11638","RHEA_ID":51711,"DIRECTION":"BI","MASTER_ID":51708,"compounds":"D-altritol + NAD(+) <=> H(+) + keto-D-tagatose + NADH","pmd":484.053}
{"X":7841,"KEGG":"R11638","RHEA_ID":51711,"DIRECTION":"BI","MASTER_ID":51708,"compounds":"D-altritol + NAD(+) <=> H(+) + keto-D-tagatose + NADH","pmd":2.016}
{"X":7842,"KEGG":"R11640","RHEA_ID":51951,"DIRECTION":"BI","MASTER_ID":51948,"compounds":"(2S)-2-methylbutanenitrile + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-2-methylbutanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":7843,"KEGG":"R11641","RHEA_ID":51963,"DIRECTION":"BI","MASTER_ID":51960,"compounds":"(Z)-2-methylpropanal oxime <=> 2-methylpropanenitrile + H2O"}
{"X":7844,"KEGG":"R11642","RHEA_ID":51967,"DIRECTION":"BI","MASTER_ID":51964,"compounds":"2-methylpropanenitrile + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-2-methylpropanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":7845,"KEGG":"R11646","RHEA_ID":51975,"DIRECTION":"BI","MASTER_ID":51972,"compounds":"an L-polyhomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":7846,"KEGG":"R11647","RHEA_ID":24323,"DIRECTION":"BI","MASTER_ID":24320,"compounds":"an L-polyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> an L-N-hydroxypolyhomomethionine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":7847,"KEGG":"R11648","RHEA_ID":51979,"DIRECTION":"BI","MASTER_ID":51976,"compounds":"an L-N-hydroxypolyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> an L-N,N-dihydroxypolyhomomethionine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":7848,"KEGG":"R11649","RHEA_ID":51983,"DIRECTION":"BI","MASTER_ID":51980,"compounds":"an L-N,N-dihydroxypolyhomomethionine + H(+) <=> an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + H2O"}
{"X":7849,"KEGG":"R11650","RHEA_ID":51995,"DIRECTION":"BI","MASTER_ID":51992,"compounds":"an (E)-omega-(methylsulfanyl)-alkanal oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] <=> an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":7850,"KEGG":"R11651","RHEA_ID":51999,"DIRECTION":"BI","MASTER_ID":51996,"compounds":"an (E)-omega-(methylsulfanyl)-alkanal oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> a 1-(methylsulfanyl)-4-aci-nitroalkane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":7851,"KEGG":"R11652","RHEA_ID":52003,"DIRECTION":"BI","MASTER_ID":52000,"compounds":"a 1-(methylsulfanyl)-4-aci-nitroalkane + glutathione <=> an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O"}
{"X":7852,"KEGG":"R11653","RHEA_ID":49283,"DIRECTION":"BI","MASTER_ID":49280,"compounds":"FADH2 + O2 + phenol <=> catechol + FAD + H(+) + H2O","pmd":2.016}
{"X":7853,"KEGG":"R11654","RHEA_ID":51927,"DIRECTION":"BI","MASTER_ID":51924,"compounds":"AH2 + menaquinone-9 <=> A + beta-dihydromenaquinone-9","pmd":2.016}
{"X":7854,"KEGG":"R11655","RHEA_ID":51931,"DIRECTION":"BI","MASTER_ID":51928,"compounds":"H2O + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + NAD(+) <=> (S)-2,3-diaminopropanoate + 2-oxoglutarate + H(+) + NADH","pmd":88.064}
{"X":7855,"KEGG":"R11655","RHEA_ID":51931,"DIRECTION":"BI","MASTER_ID":51928,"compounds":"H2O + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + NAD(+) <=> (S)-2,3-diaminopropanoate + 2-oxoglutarate + H(+) + NADH","pmd":518.095}
{"X":7856,"KEGG":"R11656","RHEA_ID":41467,"DIRECTION":"BI","MASTER_ID":41464,"compounds":"ent-sandaracopimara-8(14),15-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-sandaracopimaradien-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":7857,"KEGG":"R11657","RHEA_ID":41471,"DIRECTION":"BI","MASTER_ID":41468,"compounds":"ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oryzalexin E + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":7858,"KEGG":"R11658","RHEA_ID":41475,"DIRECTION":"BI","MASTER_ID":41472,"compounds":"ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oryzalexin D + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":7859,"KEGG":"R11659","RHEA_ID":51939,"DIRECTION":"BI","MASTER_ID":51936,"compounds":"2-(glutathione-S-yl)-hydroquinone + glutathione <=> glutathione disulfide + hydroquinone","pmd":197.047}
{"X":7860,"KEGG":"R11675","RHEA_ID":46963,"DIRECTION":"BI","MASTER_ID":46960,"compounds":"butanoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> (2E)-butenoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin]","pmd":171.024}
{"X":7861,"KEGG":"R11675","RHEA_ID":46963,"DIRECTION":"BI","MASTER_ID":46960,"compounds":"butanoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> (2E)-butenoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin]","pmd":2.016}
{"X":7862,"KEGG":"R11676","RHEA_ID":46967,"DIRECTION":"BI","MASTER_ID":46964,"compounds":"lactate + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate"}
{"X":7863,"KEGG":"R11677","RHEA_ID":47935,"DIRECTION":"BI","MASTER_ID":47932,"compounds":"(S)-3-sulfolactaldehyde + H2O + NAD(+) <=> (R)-3-sulfolactate + 2 H(+) + NADH","pmd":15.995}
{"X":7864,"KEGG":"R11677","RHEA_ID":47935,"DIRECTION":"BI","MASTER_ID":47932,"compounds":"(S)-3-sulfolactaldehyde + H2O + NAD(+) <=> (R)-3-sulfolactate + 2 H(+) + NADH","pmd":494.128}
{"X":7865,"KEGG":"R11678","RHEA_ID":47931,"DIRECTION":"BI","MASTER_ID":47928,"compounds":"(S)-3-sulfolactaldehyde + H2O + NADP(+) <=> (S)-3-sulfolactate + 2 H(+) + NADPH","pmd":15.995}
{"X":7866,"KEGG":"R11678","RHEA_ID":47931,"DIRECTION":"BI","MASTER_ID":47928,"compounds":"(S)-3-sulfolactaldehyde + H2O + NADP(+) <=> (S)-3-sulfolactate + 2 H(+) + NADPH","pmd":574.095}
{"X":7867,"KEGG":"R11679","RHEA_ID":46939,"DIRECTION":"BI","MASTER_ID":46936,"compounds":"(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) <=> ATP + H(+) + L-2-aminoadipate + NADPH","pmd":159.933}
{"X":7868,"KEGG":"R11679","RHEA_ID":46939,"DIRECTION":"BI","MASTER_ID":46936,"compounds":"(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) <=> ATP + H(+) + L-2-aminoadipate + NADPH","pmd":237.088}
{"X":7869,"KEGG":"R11679","RHEA_ID":46939,"DIRECTION":"BI","MASTER_ID":46936,"compounds":"(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) <=> ATP + H(+) + L-2-aminoadipate + NADPH","pmd":15.995}
{"X":7870,"KEGG":"R11692","RHEA_ID":57399,"DIRECTION":"BI","MASTER_ID":57396,"compounds":"(S)-S-adenosyl-L-methionine + 3-O-acetyl-4'-O-demethylpapaveroxine <=> 3-O-acetylpapaveroxine + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7871,"KEGG":"R11697","RHEA_ID":52267,"DIRECTION":"BI","MASTER_ID":52264,"compounds":"3-(aminomethyl)indole + 2 S-adenosyl-L-methionine <=> gramine + 2 H(+) + 2 S-adenosyl-L-homocysteine","pmd":28.031}
{"X":7872,"KEGG":"R11697","RHEA_ID":52267,"DIRECTION":"BI","MASTER_ID":52264,"compounds":"3-(aminomethyl)indole + 2 S-adenosyl-L-methionine <=> gramine + 2 H(+) + 2 S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7873,"KEGG":"R11698","RHEA_ID":52271,"DIRECTION":"BI","MASTER_ID":52268,"compounds":"3-(aminomethyl)indole + S-adenosyl-L-methionine <=> (1H-indol-3-yl)-N-methylmethanamine + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7874,"KEGG":"R11699","RHEA_ID":52275,"DIRECTION":"BI","MASTER_ID":52272,"compounds":"(1H-indol-3-yl)-N-methylmethanamine + S-adenosyl-L-methionine <=> gramine + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7875,"KEGG":"R11700","RHEA_ID":15432,"DIRECTION":"BI","MASTER_ID":15429,"compounds":"heme b + 2 reduced [flavodoxin] + 2 S-adenosyl-L-methionine <=> 5'-deoxyadenosine + anaerobilin + Fe(2+) + L-methionine + 2 oxidized [flavodoxin] + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7876,"KEGG":"R11700","RHEA_ID":15432,"DIRECTION":"BI","MASTER_ID":15429,"compounds":"heme b + 2 reduced [flavodoxin] + 2 S-adenosyl-L-methionine <=> 5'-deoxyadenosine + anaerobilin + Fe(2+) + L-methionine + 2 oxidized [flavodoxin] + S-adenosyl-L-homocysteine","pmd":39.904}
{"X":7877,"KEGG":"R11701","RHEA_ID":33022,"DIRECTION":"BI","MASTER_ID":33019,"compounds":"(3S)-3,6-diaminohexanoate + acetyl-CoA <=> (3S)-6-acetamido-3-aminohexanoate + CoA + H(+)","pmd":42.011}
{"X":7878,"KEGG":"R11705","RHEA_ID":52387,"DIRECTION":"BI","MASTER_ID":52384,"compounds":"L-glutamate + O-phospho-L-serine <=> H(+) + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + phosphate","pmd":49.076}
{"X":7879,"KEGG":"R11705","RHEA_ID":52387,"DIRECTION":"BI","MASTER_ID":52384,"compounds":"L-glutamate + O-phospho-L-serine <=> H(+) + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + phosphate","pmd":87.032}
{"X":7880,"KEGG":"R11706","RHEA_ID":52555,"DIRECTION":"BI","MASTER_ID":52552,"compounds":"3-dehydro-L-erythronate + ATP <=> 3-dehydro-4-O-phospho-L-erythronate + ADP + H(+)","pmd":79.966}
{"X":7881,"KEGG":"R11707","RHEA_ID":52559,"DIRECTION":"BI","MASTER_ID":52556,"compounds":"3-dehydro-D-erythronate + ATP <=> 3-dehydro-4-O-phospho-D-erythronate + ADP + H(+)","pmd":79.966}
{"X":7882,"KEGG":"R11708","RHEA_ID":52147,"DIRECTION":"BI","MASTER_ID":52144,"compounds":"3-phosphonopyruvate + acetyl-CoA + H2O <=> (R)-2-(phosphonomethyl)malate + CoA + H(+)","pmd":60.021}
{"X":7883,"KEGG":"R11708","RHEA_ID":52147,"DIRECTION":"BI","MASTER_ID":52144,"compounds":"3-phosphonopyruvate + acetyl-CoA + H2O <=> (R)-2-(phosphonomethyl)malate + CoA + H(+)","pmd":42.011}
{"X":7884,"KEGG":"R11709","RHEA_ID":52263,"DIRECTION":"BI","MASTER_ID":52260,"compounds":"a 7(1),7(1)-dihydroxybacteriochlorophyllide c <=> a bacteriochlorophyllide e + H2O"}
{"X":7885,"KEGG":"R11710","RHEA_ID":52255,"DIRECTION":"BI","MASTER_ID":52252,"compounds":"a bacteriochlorophyllide c + H2O + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + a bacteriochlorophyllide e + 2 H(+) + 2 L-methionine","pmd":147.035}
{"X":7886,"KEGG":"R11711","RHEA_ID":52327,"DIRECTION":"BI","MASTER_ID":52324,"compounds":"2 L-arginine + 4 O2 + 3 reduced [flavodoxin] <=> 5 H(+) + 4 H2O + 2 L-citrulline + 2 nitric oxide + 3 oxidized [flavodoxin]","pmd":0.984}
{"X":7887,"KEGG":"R11712","RHEA_ID":52331,"DIRECTION":"BI","MASTER_ID":52328,"compounds":"L-arginine + O2 + reduced [flavodoxin] <=> H(+) + H2O + N(omega)-hydroxy-L-arginine + oxidized [flavodoxin]","pmd":15.995}
{"X":7888,"KEGG":"R11713","RHEA_ID":52335,"DIRECTION":"BI","MASTER_ID":52332,"compounds":"2 N(omega)-hydroxy-L-arginine + 2 O2 + reduced [flavodoxin] <=> 3 H(+) + 2 H2O + 2 L-citrulline + 2 nitric oxide + oxidized [flavodoxin]","pmd":15.011}
{"X":7889,"KEGG":"R11714","RHEA_ID":53435,"DIRECTION":"BI","MASTER_ID":53432,"compounds":"an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP","pmd":162.053}
{"X":7890,"KEGG":"R11715","RHEA_ID":52383,"DIRECTION":"BI","MASTER_ID":52380,"compounds":"a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate <=> an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+)","pmd":291.095}
{"X":7891,"KEGG":"R11716","RHEA_ID":52407,"DIRECTION":"BI","MASTER_ID":52404,"compounds":"3-dehydro-4-O-phospho-L-erythronate + H(+) <=> CO2 + dihydroxyacetone phosphate","pmd":43.99}
{"X":7892,"KEGG":"R11717","RHEA_ID":52419,"DIRECTION":"BI","MASTER_ID":52416,"compounds":"3-dehydro-4-O-phospho-D-erythronate + H(+) <=> CO2 + dihydroxyacetone phosphate","pmd":43.99}
{"X":7893,"KEGG":"R11718","RHEA_ID":51019,"DIRECTION":"BI","MASTER_ID":51016,"compounds":"7,8-dihydroneopterin 3'-phosphate <=> 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde phosphate","pmd":139.988}
{"X":7894,"KEGG":"R11719","RHEA_ID":52775,"DIRECTION":"BI","MASTER_ID":52772,"compounds":"7,8-dihydroneopterin 3'-triphosphate <=> 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde triphosphate","pmd":195.076}
{"X":7895,"KEGG":"R11720","RHEA_ID":28393,"DIRECTION":"BI","MASTER_ID":28390,"ecocyc":"RXN0-4841","metacyc":"RXN0-4841","compounds":"N(6)-(D-psicosyl)-L-lysine <=> N(6)-(D-fructosyl)-L-lysine","pmd":0}
{"X":7896,"KEGG":"R11723","RHEA_ID":52803,"DIRECTION":"BI","MASTER_ID":52800,"compounds":"acetoacetyl-CoA + ATP + L-isoleucine <=> AMP + CoA + diphosphate + 2 H(+) + tenuazonic acid","pmd":159.933}
{"X":7897,"KEGG":"R11723","RHEA_ID":52803,"DIRECTION":"BI","MASTER_ID":52800,"compounds":"acetoacetyl-CoA + ATP + L-isoleucine <=> AMP + CoA + diphosphate + 2 H(+) + tenuazonic acid","pmd":84.021}
{"X":7898,"KEGG":"R11723","RHEA_ID":52803,"DIRECTION":"BI","MASTER_ID":52800,"compounds":"acetoacetyl-CoA + ATP + L-isoleucine <=> AMP + CoA + diphosphate + 2 H(+) + tenuazonic acid","pmd":66.011}
{"X":7899,"KEGG":"R11724","RHEA_ID":52399,"DIRECTION":"BI","MASTER_ID":52396,"compounds":"4-O-phospho-D-threonate + NAD(+) <=> CO2 + dihydroxyacetone phosphate + NADH","pmd":46.006}
{"X":7900,"KEGG":"R11724","RHEA_ID":52399,"DIRECTION":"BI","MASTER_ID":52396,"compounds":"4-O-phospho-D-threonate + NAD(+) <=> CO2 + dihydroxyacetone phosphate + NADH","pmd":494.119}
{"X":7901,"KEGG":"R11726","RHEA_ID":52411,"DIRECTION":"BI","MASTER_ID":52408,"compounds":"4-phospho-D-erythronate + NAD(+) <=> CO2 + dihydroxyacetone phosphate + NADH","pmd":494.119}
{"X":7902,"KEGG":"R11726","RHEA_ID":52411,"DIRECTION":"BI","MASTER_ID":52408,"compounds":"4-phospho-D-erythronate + NAD(+) <=> CO2 + dihydroxyacetone phosphate + NADH","pmd":46.006}
{"X":7903,"KEGG":"R11730","RHEA_ID":41214,"DIRECTION":"BI","MASTER_ID":41211,"compounds":"(indol-3-yl)acetate + H(+) + NADH + O2 <=> 2-hydroxy-(1H-indol-3-yl)acetate + H2O + NAD(+)","pmd":474.067}
{"X":7904,"KEGG":"R11730","RHEA_ID":41214,"DIRECTION":"BI","MASTER_ID":41211,"compounds":"(indol-3-yl)acetate + H(+) + NADH + O2 <=> 2-hydroxy-(1H-indol-3-yl)acetate + H2O + NAD(+)","pmd":15.995}
{"X":7905,"KEGG":"R11732","RHEA_ID":52159,"DIRECTION":"BI","MASTER_ID":52156,"compounds":"(E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> (R)-mandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]","pmd":2.016}
{"X":7906,"KEGG":"R11733","RHEA_ID":52167,"DIRECTION":"BI","MASTER_ID":52164,"compounds":"O2 + phenylacetonitrile + reduced [NADPH--hemoprotein reductase] <=> (R)-mandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":7907,"KEGG":"R11734","RHEA_ID":52183,"DIRECTION":"BI","MASTER_ID":52180,"compounds":"(E)-(indol-3-yl)acetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] <=> (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]","pmd":172.064}
{"X":7908,"KEGG":"R11734","RHEA_ID":52183,"DIRECTION":"BI","MASTER_ID":52180,"compounds":"(E)-(indol-3-yl)acetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] <=> (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]","pmd":305.068}
{"X":7909,"KEGG":"R11735","RHEA_ID":52187,"DIRECTION":"BI","MASTER_ID":52184,"compounds":"(E)-(indol-3-yl)acetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> 1-aci-nitro-2-(1H-indol-3-yl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":7910,"KEGG":"R11736","RHEA_ID":52191,"DIRECTION":"BI","MASTER_ID":52188,"compounds":"1-aci-nitro-2-(1H-indol-3-yl)ethane + glutathione <=> (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O","pmd":172.064}
{"X":7911,"KEGG":"R11736","RHEA_ID":52191,"DIRECTION":"BI","MASTER_ID":52188,"compounds":"1-aci-nitro-2-(1H-indol-3-yl)ethane + glutathione <=> (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O","pmd":289.073}
{"X":7912,"KEGG":"R11737","RHEA_ID":52195,"DIRECTION":"BI","MASTER_ID":52192,"compounds":"(E)-phenylacetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] <=> (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]","pmd":133.053}
{"X":7913,"KEGG":"R11737","RHEA_ID":52195,"DIRECTION":"BI","MASTER_ID":52192,"compounds":"(E)-phenylacetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] <=> (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]","pmd":305.068}
{"X":7914,"KEGG":"R11738","RHEA_ID":52199,"DIRECTION":"BI","MASTER_ID":52196,"compounds":"(E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> 1-aci-nitro-2-(phenyl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":7915,"KEGG":"R11739","RHEA_ID":52203,"DIRECTION":"BI","MASTER_ID":52200,"compounds":"1-aci-nitro-2-(phenyl)ethane + glutathione <=> (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O","pmd":289.073}
{"X":7916,"KEGG":"R11739","RHEA_ID":52203,"DIRECTION":"BI","MASTER_ID":52200,"compounds":"1-aci-nitro-2-(phenyl)ethane + glutathione <=> (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O","pmd":133.053}
{"X":7917,"KEGG":"R11741","RHEA_ID":52235,"DIRECTION":"BI","MASTER_ID":52232,"compounds":"3 AH2 + 2 H(+) + heme b + 3 O2 <=> 3 A + Fe(2+) + 3 H2O + mycobilin a","pmd":5.935}
{"X":7918,"KEGG":"R11742","RHEA_ID":52239,"DIRECTION":"BI","MASTER_ID":52236,"compounds":"3 AH2 + 2 H(+) + heme b + 3 O2 <=> 3 A + Fe(2+) + 3 H2O + mycobilin b","pmd":5.935}
{"X":7919,"KEGG":"R11744","RHEA_ID":52887,"DIRECTION":"BI","MASTER_ID":52884,"compounds":"H2O + N-phenylhydroxylamine + 2 NADP(+) <=> 2 H(+) + 2 NADPH + nitrobenzene","pmd":621.051}
{"X":7920,"KEGG":"R11744","RHEA_ID":52887,"DIRECTION":"BI","MASTER_ID":52884,"compounds":"H2O + N-phenylhydroxylamine + 2 NADP(+) <=> 2 H(+) + 2 NADPH + nitrobenzene","pmd":13.979}
{"X":7921,"KEGG":"R11749","RHEA_ID":57731,"DIRECTION":"BI","MASTER_ID":57728,"compounds":"H(+) + trans-aconitate <=> CO2 + itaconate","pmd":43.99}
{"X":7922,"KEGG":"R11773","RHEA_ID":28013,"DIRECTION":"BI","MASTER_ID":28010,"ecocyc":"RXN0-268","metacyc":"RXN0-268","compounds":"propanoyl-CoA + succinate <=> propanoate + succinyl-CoA","pmd":749.105}
{"X":7923,"KEGG":"R11773","RHEA_ID":28013,"DIRECTION":"BI","MASTER_ID":28010,"ecocyc":"RXN0-268","metacyc":"RXN0-268","compounds":"propanoyl-CoA + succinate <=> propanoate + succinyl-CoA","pmd":43.99}
{"X":7924,"KEGG":"R11774","RHEA_ID":54799,"DIRECTION":"BI","MASTER_ID":54796,"compounds":"a (2R,3S)-2-alkyl-3-hydroxyalkanoate + NADP(+) <=> an (R)-2-alkyl-3-oxoalkanoate + H(+) + NADPH"}
{"X":7925,"KEGG":"R11775","RHEA_ID":23063,"DIRECTION":"BI","MASTER_ID":23060,"compounds":"a (2R,3S)-2-alkyl-3-hydroxyalkanoate + ATP <=> a cis-3-alkyl-4-alkyloxetan-2-one + AMP + diphosphate","pmd":159.933}
{"X":7926,"KEGG":"R11776","RHEA_ID":18944,"DIRECTION":"BI","MASTER_ID":18941,"compounds":"a (3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one + NADP(+) <=> a (3R,4R)-3-alkanoyl-4-(hydroxymethyl)oxolan-2-one + H(+) + NADPH"}
{"X":7927,"KEGG":"R11777","RHEA_ID":52487,"DIRECTION":"BI","MASTER_ID":52484,"compounds":"(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + A <=> (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + AH2","pmd":2.016}
{"X":7928,"KEGG":"R11778","RHEA_ID":51947,"DIRECTION":"BI","MASTER_ID":51944,"compounds":"8-amino-8-demethylriboflavin + 2 S-adenosyl-L-methionine <=> 2 H(+) + roseoflavin + 2 S-adenosyl-L-homocysteine","pmd":6.988}
{"X":7929,"KEGG":"R11778","RHEA_ID":51947,"DIRECTION":"BI","MASTER_ID":51944,"compounds":"8-amino-8-demethylriboflavin + 2 S-adenosyl-L-methionine <=> 2 H(+) + roseoflavin + 2 S-adenosyl-L-homocysteine","pmd":7.028}
{"X":7930,"KEGG":"R11779","RHEA_ID":53419,"DIRECTION":"BI","MASTER_ID":53416,"compounds":"8-amino-8-demethylriboflavin + S-adenosyl-L-methionine <=> 8-demethyl-8-(methylamino)riboflavin + H(+) + S-adenosyl-L-homocysteine","pmd":6.988}
{"X":7931,"KEGG":"R11780","RHEA_ID":53423,"DIRECTION":"BI","MASTER_ID":53420,"compounds":"8-demethyl-8-(methylamino)riboflavin + S-adenosyl-L-methionine <=> H(+) + roseoflavin + S-adenosyl-L-homocysteine","pmd":7.028}
{"X":7932,"KEGG":"R11782","RHEA_ID":47415,"DIRECTION":"BI","MASTER_ID":47412,"compounds":"1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1->2)-D-myo-inositol] + an acyl-CoA <=> 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1->2)-D-myo-inositol] + CoA"}
{"X":7933,"KEGG":"R11783","RHEA_ID":53883,"DIRECTION":"BI","MASTER_ID":53880,"compounds":"ADP-alpha-D-glucose + D-glucose 6-phosphate <=> ADP + alpha,alpha-trehalose 6-phosphate + H(+)","pmd":162.053}
{"X":7934,"KEGG":"R11784","RHEA_ID":52391,"DIRECTION":"BI","MASTER_ID":52388,"compounds":"ATP + D-threonate <=> 4-O-phospho-D-threonate + ADP + H(+)","pmd":79.966}
{"X":7935,"KEGG":"R11785","RHEA_ID":53731,"DIRECTION":"BI","MASTER_ID":53728,"compounds":"H2O + N-acetyl-D-muramate 6-phosphate <=> N-acetyl-D-muramate + phosphate","pmd":79.966}
{"X":7936,"KEGG":"R11786","RHEA_ID":11831,"DIRECTION":"BI","MASTER_ID":11828,"compounds":"H2O + RNA(n)-2',3'-cyclic phosphate <=> H(+) + RNA(n)-2'- phosphate"}
{"X":7937,"KEGG":"R11787","RHEA_ID":54675,"DIRECTION":"BI","MASTER_ID":54672,"compounds":"(+)-kolavenyl diphosphate + H2O <=> (+)-kolavelool + diphosphate","pmd":159.933}
{"X":7938,"KEGG":"R11788","RHEA_ID":24847,"DIRECTION":"BI","MASTER_ID":24844,"compounds":"cyclobis-(1->3)-alpha-isomaltosyl + 2 H2O <=> 2 isomaltose","pmd":306.095}
{"X":7939,"KEGG":"R11789","RHEA_ID":52747,"DIRECTION":"BI","MASTER_ID":52744,"compounds":"cyclobis-(1->3)-alpha-isomaltosyl + H2O <=> alpha-isomaltosyl-(1->3)-isomaltose","pmd":18.011}
{"X":7940,"KEGG":"R11790","RHEA_ID":52751,"DIRECTION":"BI","MASTER_ID":52748,"compounds":"alpha-isomaltosyl-(1->3)-isomaltose + H2O <=> 2 isomaltose","pmd":324.106}
{"X":7941,"KEGG":"R11791","RHEA_ID":52755,"DIRECTION":"BI","MASTER_ID":52752,"compounds":"H2O + isomaltose <=> beta-D-glucose + D-glucose","pmd":162.053}
{"X":7942,"KEGG":"R11792","RHEA_ID":52759,"DIRECTION":"BI","MASTER_ID":52756,"compounds":"an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O <=> an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-cysteinylglycine + L-glutamate"}
{"X":7943,"KEGG":"R11793","RHEA_ID":52767,"DIRECTION":"BI","MASTER_ID":52764,"compounds":"(E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O <=> (E)-1-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetohydroximate + L-glutamate","pmd":129.043}
{"X":7944,"KEGG":"R11794","RHEA_ID":52771,"DIRECTION":"BI","MASTER_ID":52768,"compounds":"2-(glutathion-S-yl)-2-(1H-indol-3-yl)acetonitrile + H2O <=> 2-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetonitrile + L-glutamate","pmd":129.043}
{"X":7945,"KEGG":"R11795","RHEA_ID":52763,"DIRECTION":"BI","MASTER_ID":52760,"compounds":"(Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O <=> (Z)-1-(glycyl-L-cystein-S-yl)-2-phenylacetohydroximate + L-glutamate","pmd":129.043}
{"X":7946,"KEGG":"R11797","RHEA_ID":20464,"DIRECTION":"BI","MASTER_ID":20461,"compounds":"an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + 3 S-adenosyl-L-methionine <=> an N,N,N-trimethylornithine lipid + 3 H(+) + 3 S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7947,"KEGG":"R11798","RHEA_ID":55031,"DIRECTION":"BI","MASTER_ID":55028,"compounds":"an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + S-adenosyl-L-methionine <=> an N-methylornithine lipid + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7948,"KEGG":"R11799","RHEA_ID":55035,"DIRECTION":"BI","MASTER_ID":55032,"compounds":"an N-methylornithine lipid + S-adenosyl-L-methionine <=> an N,N-dimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7949,"KEGG":"R11800","RHEA_ID":55039,"DIRECTION":"BI","MASTER_ID":55036,"compounds":"an N,N-dimethylornithine lipid + S-adenosyl-L-methionine <=> an N,N,N-trimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":7950,"KEGG":"R11801","RHEA_ID":20636,"DIRECTION":"BI","MASTER_ID":20633,"compounds":"a (3R)-hydroxyacyl-[ACP] + L-ornithine <=> a lyso-ornithine lipid + H(+) + holo-[ACP]"}
{"X":7951,"KEGG":"R11802","RHEA_ID":55391,"DIRECTION":"BI","MASTER_ID":55388,"compounds":"(3R)-3-hydroxy-2,3-dihydrotabersonine + A <=> (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + AH2","pmd":2.016}
{"X":7952,"KEGG":"R11803","RHEA_ID":52395,"DIRECTION":"BI","MASTER_ID":52392,"compounds":"ATP + D-erythronate <=> 4-phospho-D-erythronate + ADP + H(+)","pmd":79.966}
{"X":7953,"KEGG":"R11804","RHEA_ID":42211,"DIRECTION":"BI","MASTER_ID":42208,"compounds":"an omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + H(+) + NADPH + O2 <=> an omega-(methylsulfinyl)-alkyl-glucosinolate + H2O + NADP(+)"}
{"X":7954,"KEGG":"R11805","RHEA_ID":54831,"DIRECTION":"BI","MASTER_ID":54828,"compounds":"dimethylamine + H(+) + NADPH + O2 <=> formaldehyde + H2O + methylamine + NADP(+)"}
{"X":7955,"KEGG":"R11806","RHEA_ID":54835,"DIRECTION":"BI","MASTER_ID":54832,"compounds":"a jasmonyl-L-amino acid + O2 + reduced [NADPH--hemoprotein reductase] <=> a 12-hydroxyjasmonyl-L-alpha-amino acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":7956,"KEGG":"R11807","RHEA_ID":55059,"DIRECTION":"BI","MASTER_ID":55056,"compounds":"a 12-hydroxyjasmonyl-L-alpha-amino acid + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":7957,"KEGG":"R11808","RHEA_ID":55063,"DIRECTION":"BI","MASTER_ID":55060,"compounds":"a 12-hydroxyjasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase] <=> a 12-oxojasmonyl-L-alpha-amino acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":7958,"KEGG":"R11809","RHEA_ID":55071,"DIRECTION":"BI","MASTER_ID":55068,"compounds":"a 12-oxojasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase] <=> a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":7959,"KEGG":"R11810","RHEA_ID":52483,"DIRECTION":"BI","MASTER_ID":52480,"compounds":"16-methoxytabersonine + O2 + reduced [NADPH--hemoprotein reductase] <=> (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":7960,"KEGG":"R11811","RHEA_ID":55027,"DIRECTION":"BI","MASTER_ID":55024,"compounds":"(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] <=> (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":7961,"KEGG":"R11812","RHEA_ID":52207,"DIRECTION":"BI","MASTER_ID":52204,"compounds":"butachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> butyl formate + H2O + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]","pmd":86.073}
{"X":7962,"KEGG":"R11813","RHEA_ID":52779,"DIRECTION":"BI","MASTER_ID":52776,"compounds":"2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> camalexin + CO2 + 2 H(+) + 4 H2O + hydrogen cyanide + 2 oxidized [NADPH--hemoprotein reductase]","pmd":75.032}
{"X":7963,"KEGG":"R11814","RHEA_ID":10455,"DIRECTION":"BI","MASTER_ID":10452,"compounds":"2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + O2 + reduced [NADPH--hemoprotein reductase] <=> (R)-dihydrocamalexate + 2 H(+) + 2 H2O + hydrogen cyanide + oxidized [NADPH--hemoprotein reductase]","pmd":29.026}
{"X":7964,"KEGG":"R11815","RHEA_ID":34810,"DIRECTION":"BI","MASTER_ID":34807,"compounds":"(R)-dihydrocamalexate + O2 + reduced [NADPH--hemoprotein reductase] <=> camalexin + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase]","pmd":46.006}
{"X":7965,"KEGG":"R11816","RHEA_ID":52227,"DIRECTION":"BI","MASTER_ID":52224,"compounds":"3 AH2 + 3 H(+) + heme b + 3 O2 <=> 3 A + biliverdin delta + CO + Fe(2+) + 3 H2O","pmd":33.929}
{"X":7966,"KEGG":"R11817","RHEA_ID":52231,"DIRECTION":"BI","MASTER_ID":52228,"compounds":"3 AH2 + 2 H(+) + heme b + 3 O2 <=> 3 A + biliverdin beta + CO + Fe(2+) + 3 H2O","pmd":33.929}
{"X":7967,"KEGG":"R11818","RHEA_ID":46955,"DIRECTION":"BI","MASTER_ID":46952,"compounds":"2 formate + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2 CO2 + H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":7968,"KEGG":"R11819","RHEA_ID":54647,"DIRECTION":"BI","MASTER_ID":54644,"compounds":"trans-4-hydroxy-L-proline <=> (S)-1-pyrroline-5-carboxylate + H(+) + H2O","pmd":18.01}
{"X":7969,"KEGG":"R11820","RHEA_ID":54651,"DIRECTION":"BI","MASTER_ID":54648,"compounds":"ent-8alpha-hydroxylabd-13-en-15-yl diphosphate <=> all-trans-geranylgeranyl diphosphate + H2O","pmd":18.011}
{"X":7970,"KEGG":"R11821","RHEA_ID":54655,"DIRECTION":"BI","MASTER_ID":54652,"compounds":"peregrinol diphosphate <=> all-trans-geranylgeranyl diphosphate + H2O","pmd":18.011}
{"X":7971,"KEGG":"R11822","RHEA_ID":53619,"DIRECTION":"BI","MASTER_ID":53616,"compounds":"(2E,6E)-farnesyl diphosphate + H2O <=> (+)-isoafricanol + diphosphate","pmd":159.933}
{"X":7972,"KEGG":"R11823","RHEA_ID":53623,"DIRECTION":"BI","MASTER_ID":53620,"compounds":"all-trans-geranylgeranyl diphosphate <=> (-)-spiroviolene + diphosphate","pmd":177.943}
{"X":7973,"KEGG":"R11824","RHEA_ID":53627,"DIRECTION":"BI","MASTER_ID":53624,"compounds":"all-trans-geranylgeranyl diphosphate <=> diphosphate + tsukubadiene","pmd":177.943}
{"X":7974,"KEGG":"R11825","RHEA_ID":53631,"DIRECTION":"BI","MASTER_ID":53628,"compounds":"(2E,6E)-farnesyl diphosphate <=> (2S,3R,6S,9S)-(-)-protoillud-7-ene + diphosphate","pmd":177.943}
{"X":7975,"KEGG":"R11826","RHEA_ID":53635,"DIRECTION":"BI","MASTER_ID":53632,"compounds":"(2E,6E)-farnesyl diphosphate <=> (3S)-(+)-asterisca-2(9),6-diene + diphosphate","pmd":177.943}
{"X":7976,"KEGG":"R11827","RHEA_ID":53643,"DIRECTION":"BI","MASTER_ID":53640,"compounds":"(2E,6E)-farnesyl diphosphate <=> (-)-alpha-amorphene + diphosphate","pmd":177.943}
{"X":7977,"KEGG":"R11828","RHEA_ID":53647,"DIRECTION":"BI","MASTER_ID":53644,"compounds":"(2E,6E)-farnesyl diphosphate + H2O <=> (+)-corvol ether B + diphosphate","pmd":159.933}
{"X":7978,"KEGG":"R11829","RHEA_ID":52807,"DIRECTION":"BI","MASTER_ID":52804,"compounds":"(2E,6E)-farnesyl diphosphate <=> (+)-eremophilene + diphosphate","pmd":177.943}
{"X":7979,"KEGG":"R11830","RHEA_ID":53671,"DIRECTION":"BI","MASTER_ID":53668,"compounds":"(2E,6E)-farnesyl diphosphate <=> (1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate","pmd":177.943}
{"X":7980,"KEGG":"R11831","RHEA_ID":12195,"DIRECTION":"BI","MASTER_ID":12192,"compounds":"(2E,6E)-farnesyl diphosphate + H2O <=> (+)-(1(10)E,4E,6S,7R)-germacradien-6-ol + diphosphate","pmd":159.933}
{"X":7981,"KEGG":"R11832","RHEA_ID":16348,"DIRECTION":"BI","MASTER_ID":16345,"compounds":"all-trans-geranylgeranyl diphosphate + H2O <=> (3E,7E)-dolabella-3,7-dien-18-ol + diphosphate","pmd":159.933}
{"X":7982,"KEGG":"R11833","RHEA_ID":54043,"DIRECTION":"BI","MASTER_ID":54040,"compounds":"all-trans-geranylgeranyl diphosphate <=> (3E,7E)-dolathalia-3,7,11-triene + diphosphate","pmd":177.943}
{"X":7983,"KEGG":"R11834","RHEA_ID":54047,"DIRECTION":"BI","MASTER_ID":54044,"compounds":"(2E,6E)-farnesyl diphosphate + H2O <=> 7-epi-alpha-eudesmol + diphosphate","pmd":159.933}
{"X":7984,"KEGG":"R11835","RHEA_ID":54051,"DIRECTION":"BI","MASTER_ID":54048,"compounds":"(2E,6E)-farnesyl diphosphate + H2O <=> 4-epi-cubebol + diphosphate","pmd":159.933}
{"X":7985,"KEGG":"R11836","RHEA_ID":53651,"DIRECTION":"BI","MASTER_ID":53648,"compounds":"(2E,6E)-farnesyl diphosphate + H2O <=> (+)-corvol ether A + diphosphate","pmd":159.933}
{"X":7986,"KEGG":"R11837","RHEA_ID":14488,"DIRECTION":"BI","MASTER_ID":14485,"compounds":"(2E,6E)-farnesyl diphosphate + H2O <=> 10-epi-juneol + diphosphate","pmd":159.933}
{"X":7987,"KEGG":"R11838","RHEA_ID":54055,"DIRECTION":"BI","MASTER_ID":54052,"compounds":"(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + tau-cadinol","pmd":159.933}
{"X":7988,"KEGG":"R11839","RHEA_ID":54059,"DIRECTION":"BI","MASTER_ID":54056,"compounds":"(2E,6E)-farnesyl diphosphate + H2O <=> (2E,6E)-hedycaryol + diphosphate","pmd":159.933}
{"X":7989,"KEGG":"R11840","RHEA_ID":54067,"DIRECTION":"BI","MASTER_ID":54064,"compounds":"(2E,6E)-farnesyl diphosphate + H2O <=> 10-epi-cubebol + diphosphate","pmd":159.933}
{"X":7990,"KEGG":"R11841","RHEA_ID":54071,"DIRECTION":"BI","MASTER_ID":54068,"compounds":"(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O <=> diphosphate + sesterfisherol","pmd":159.933}
{"X":7991,"KEGG":"R11842","RHEA_ID":54075,"DIRECTION":"BI","MASTER_ID":54072,"compounds":"(2E)-geranyl diphosphate <=> beta-thujene + diphosphate","pmd":177.943}
{"X":7992,"KEGG":"R11843","RHEA_ID":54079,"DIRECTION":"BI","MASTER_ID":54076,"compounds":"(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> diphosphate + stellata-2,6,19-triene","pmd":177.943}
{"X":7993,"KEGG":"R11844","RHEA_ID":54111,"DIRECTION":"BI","MASTER_ID":54108,"compounds":"(2E,6E)-farnesyl diphosphate <=> diphosphate + guaia-4,6-diene","pmd":177.943}
{"X":7994,"KEGG":"R11845","RHEA_ID":54119,"DIRECTION":"BI","MASTER_ID":54116,"compounds":"all-trans-geranylgeranyl diphosphate <=> diphosphate + pseudolaratriene","pmd":177.943}
{"X":7995,"KEGG":"R11846","RHEA_ID":54115,"DIRECTION":"BI","MASTER_ID":54112,"compounds":"(2E,6E)-farnesyl diphosphate <=> diphosphate + selina-4(15),7(11)-diene","pmd":177.943}
{"X":7996,"KEGG":"R11847","RHEA_ID":54375,"DIRECTION":"BI","MASTER_ID":54372,"compounds":"(2E,6E)-farnesyl diphosphate + H2O <=> (+)-(2S,3R,9R)-pristinol + diphosphate","pmd":159.933}
{"X":7997,"KEGG":"R11848","RHEA_ID":54379,"DIRECTION":"BI","MASTER_ID":54376,"compounds":"(+)-copalyl diphosphate + H2O <=> diphosphate + nezukol","pmd":159.933}
{"X":7998,"KEGG":"R11849","RHEA_ID":54383,"DIRECTION":"BI","MASTER_ID":54380,"compounds":"(2E,6E)-farnesyl diphosphate + H2O <=> 5-hydroxy-alpha-gurjunene + diphosphate","pmd":159.933}
{"X":7999,"KEGG":"R11850","RHEA_ID":54499,"DIRECTION":"BI","MASTER_ID":54496,"compounds":"ent-copalyl diphosphate <=> diphosphate + ent-atiserene","pmd":177.943}
{"X":8000,"KEGG":"R11851","RHEA_ID":18724,"DIRECTION":"BI","MASTER_ID":18721,"compounds":"ent-8alpha-hydroxylabd-13-en-15-yl diphosphate <=> diphosphate + ent-13-epi-manoyl oxide","pmd":177.943}
{"X":8001,"KEGG":"R11852","RHEA_ID":54063,"DIRECTION":"BI","MASTER_ID":54060,"compounds":"(2E,6E)-farnesyl diphosphate + H2O <=> (2Z,6E)-hedycaryol + diphosphate","pmd":159.933}
{"X":8002,"KEGG":"R11853","RHEA_ID":54503,"DIRECTION":"BI","MASTER_ID":54500,"compounds":"(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> beta-geranylfarnesene + diphosphate","pmd":177.943}
{"X":8003,"KEGG":"R11854","RHEA_ID":54507,"DIRECTION":"BI","MASTER_ID":54504,"compounds":"all-trans-hexaprenyl diphosphate <=> beta-hexaprene + diphosphate","pmd":177.943}
{"X":8004,"KEGG":"R11856","RHEA_ID":54515,"DIRECTION":"BI","MASTER_ID":54512,"compounds":"peregrinol diphosphate <=> (13R)-9,13-epoxylabd-14-ene + diphosphate","pmd":177.943}
{"X":8005,"KEGG":"R11857","RHEA_ID":54519,"DIRECTION":"BI","MASTER_ID":54516,"compounds":"8-hydroxycopalyl diphosphate <=> (13R)-manoyl oxide + diphosphate","pmd":177.943}
{"X":8006,"KEGG":"R11858","RHEA_ID":54523,"DIRECTION":"BI","MASTER_ID":54520,"compounds":"all-trans-geranylgeranyl diphosphate <=> cycloaraneosene + diphosphate","pmd":177.943}
{"X":8007,"KEGG":"R11859","RHEA_ID":54639,"DIRECTION":"BI","MASTER_ID":54636,"compounds":"(13E)-labda-7,13-dien-15-yl diphosphate <=> diphosphate + labda-7,13(16),14-triene","pmd":177.943}
{"X":8008,"KEGG":"R11860","RHEA_ID":54643,"DIRECTION":"BI","MASTER_ID":54640,"compounds":"(+)-copalyl diphosphate <=> (12E)-labda-8(17),12,14-triene + diphosphate","pmd":177.943}
{"X":8009,"KEGG":"R11861","RHEA_ID":47727,"DIRECTION":"BI","MASTER_ID":47724,"compounds":"glutathione <=> 5-oxo-L-proline + L-cysteinylglycine","pmd":129.043}
{"X":8010,"KEGG":"R11862","RHEA_ID":16964,"DIRECTION":"BI","MASTER_ID":16961,"compounds":"epsilon-(gamma-L-glutamyl)-L-lysine <=> 5-oxo-L-proline + L-lysine","pmd":129.043}
{"X":8011,"KEGG":"R11864","RHEA_ID":52783,"DIRECTION":"BI","MASTER_ID":52780,"compounds":"H2O + S-(hercyn-2-yl)-L-cysteine S-oxide <=> 2-sulfenohercynine + NH4(+) + pyruvate","pmd":87.032}
{"X":8012,"KEGG":"R11865","RHEA_ID":52787,"DIRECTION":"BI","MASTER_ID":52784,"compounds":"2-sulfenohercynine + AH2 + H(+) <=> A + ergothioneine + H2O","pmd":15.995}
{"X":8013,"KEGG":"R11866","RHEA_ID":54659,"DIRECTION":"BI","MASTER_ID":54656,"metacyc":"RXN-18768","compounds":"linalool <=> geraniol","pmd":0}
{"X":8014,"KEGG":"R11867","RHEA_ID":54667,"DIRECTION":"BI","MASTER_ID":54664,"compounds":"(3S,22S)-2,3:22,23-diepoxy-2,3,22,23-tetrahydrosqualene <=> pre-alpha-onocerin","pmd":0}
{"X":8015,"KEGG":"R11868","RHEA_ID":54671,"DIRECTION":"BI","MASTER_ID":54668,"compounds":"pre-alpha-onocerin <=> alpha-onocerin","pmd":0}
{"X":8016,"KEGG":"R11869","RHEA_ID":54687,"DIRECTION":"BI","MASTER_ID":54684,"compounds":"all-trans-geranylgeranyl diphosphate <=> (-)-kolavenyl diphosphate","pmd":0}
{"X":8017,"KEGG":"R11870","RHEA_ID":54679,"DIRECTION":"BI","MASTER_ID":54676,"compounds":"all-trans-geranylgeranyl diphosphate <=> (+)-kolavenyl diphosphate","pmd":0}
{"X":8018,"KEGG":"R11871","RHEA_ID":54695,"DIRECTION":"BI","MASTER_ID":54692,"compounds":"all-trans-geranylgeranyl diphosphate <=> (13E)-labda-7,13-dien-15-yl diphosphate","pmd":0}
{"X":8019,"KEGG":"R11872","RHEA_ID":54699,"DIRECTION":"BI","MASTER_ID":54696,"compounds":"4-hydroxybenzoate + ATP + holo-[4-hydroxyphenylalkanoate synthase] <=> 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + diphosphate","pmd":209.031}
{"X":8020,"KEGG":"R11872","RHEA_ID":54699,"DIRECTION":"BI","MASTER_ID":54696,"compounds":"4-hydroxybenzoate + ATP + holo-[4-hydroxyphenylalkanoate synthase] <=> 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + diphosphate","pmd":159.933}
{"X":8021,"KEGG":"R11873","RHEA_ID":54703,"DIRECTION":"BI","MASTER_ID":54700,"compounds":"4-hydroxybenzoyl-5'-AMP + holo-[4-hydroxyphenylalkanoate synthase] <=> 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + H(+)","pmd":120.021}
{"X":8022,"KEGG":"R11874","RHEA_ID":54755,"DIRECTION":"BI","MASTER_ID":54752,"compounds":"methanophenazine + reduced coenzyme F420-(gamma-Glu)(n) <=> dihydromethanophenazine + H(+) + oxidized coenzyme F420-(gamma-Glu)(n)","pmd":2.016}
{"X":8023,"KEGG":"R11875","RHEA_ID":55399,"DIRECTION":"BI","MASTER_ID":55396,"compounds":"(R)-carnitine + H(+) + NADH + O2 <=> (3R)-3-hydroxy-4-oxobutanoate + H2O + NAD(+) + trimethylamine","pmd":43.079}
{"X":8024,"KEGG":"R11875","RHEA_ID":55399,"DIRECTION":"BI","MASTER_ID":55396,"compounds":"(R)-carnitine + H(+) + NADH + O2 <=> (3R)-3-hydroxy-4-oxobutanoate + H2O + NAD(+) + trimethylamine","pmd":547.098}
{"X":8025,"KEGG":"R11876","RHEA_ID":54807,"DIRECTION":"BI","MASTER_ID":54804,"compounds":"2 4-sulfanylbutanoate + NAD(+) <=> 4,4'-disulfanyldibutanoate + H(+) + NADH","pmd":118.009}
{"X":8026,"KEGG":"R11876","RHEA_ID":54807,"DIRECTION":"BI","MASTER_ID":54804,"compounds":"2 4-sulfanylbutanoate + NAD(+) <=> 4,4'-disulfanyldibutanoate + H(+) + NADH","pmd":426.083}
{"X":8027,"KEGG":"R11877","RHEA_ID":56287,"DIRECTION":"BI","MASTER_ID":56284,"compounds":"a (3R,4R)-4,2'-dihydroxyisoflavan + NADP(+) <=> a (3R)-2'-hydroxyisoflavanone + H(+) + NADPH","pmd":2.016}
{"X":8028,"KEGG":"R11877","RHEA_ID":56287,"DIRECTION":"BI","MASTER_ID":56284,"compounds":"a (3R,4R)-4,2'-dihydroxyisoflavan + NADP(+) <=> a (3R)-2'-hydroxyisoflavanone + H(+) + NADPH","pmd":504.005}
{"X":8029,"KEGG":"R11880","RHEA_ID":52243,"DIRECTION":"BI","MASTER_ID":52240,"compounds":"2 H2O + 2 Mn(2+) + O2 <=> 4 H(+) + 2 MnO2"}
{"X":8030,"KEGG":"R11881","RHEA_ID":52247,"DIRECTION":"BI","MASTER_ID":52244,"compounds":"4 H(+) + 4 Mn(2+) + O2 <=> 2 H2O + 4 Mn(3+)"}
{"X":8031,"KEGG":"R11882","RHEA_ID":52251,"DIRECTION":"BI","MASTER_ID":52248,"compounds":"6 H2O + 4 Mn(3+) + O2 <=> 12 H(+) + 4 MnO2"}
{"X":8032,"KEGG":"R11889","RHEA_ID":27472,"DIRECTION":"BI","MASTER_ID":27469,"compounds":"H2O + N,N'-diacetylchitobiose <=> acetate + N-acetyl-beta-D-glucosaminyl-(1->4)-D-glucosamine","pmd":42.011}
{"X":8033,"KEGG":"R11911","RHEA_ID":55371,"DIRECTION":"BI","MASTER_ID":55368,"compounds":"(R)-carnitine + H(+) + NADPH + O2 <=> (3R)-3-hydroxy-4-oxobutanoate + H2O + NADP(+) + trimethylamine","pmd":627.064}
{"X":8034,"KEGG":"R11911","RHEA_ID":55371,"DIRECTION":"BI","MASTER_ID":55368,"compounds":"(R)-carnitine + H(+) + NADPH + O2 <=> (3R)-3-hydroxy-4-oxobutanoate + H2O + NADP(+) + trimethylamine","pmd":43.079}
{"X":8035,"KEGG":"R11912","RHEA_ID":15868,"DIRECTION":"BI","MASTER_ID":15865,"compounds":"AH2 + O2 + tryptamine <=> 4-hydroxytryptamine + A + H2O","pmd":15.995}
{"X":8036,"KEGG":"R11913","RHEA_ID":44719,"DIRECTION":"BI","MASTER_ID":44716,"compounds":"A + all-trans-4,4'-diapolycopen-4-al + H2O <=> AH2 + all-trans-4,4'-diapolycopen-4-oate + H(+)","pmd":15.995}
{"X":8037,"KEGG":"R11914","RHEA_ID":42383,"DIRECTION":"BI","MASTER_ID":42380,"compounds":"2 A + all-trans-4,4'-diapolycopene-4,4'-dial + 2 H2O <=> 2 AH2 + all-trans-4,4'-diapolycopene-4,4'-dioate + 2 H(+)","pmd":31.99}
{"X":8038,"KEGG":"R11915","RHEA_ID":18972,"DIRECTION":"BI","MASTER_ID":18969,"compounds":"a long-chain fatty acid + H(+) + hnu <=> a long-chain alkane + CO2"}
{"X":8039,"KEGG":"R11916","RHEA_ID":55527,"DIRECTION":"BI","MASTER_ID":55524,"compounds":"H(+) + H2O + L-dopa + O2 <=> 3,4-dihydroxyphenylacetaldehyde + CO2 + H2O2 + NH4(+)","pmd":45.022}
{"X":8040,"KEGG":"R11917","RHEA_ID":55531,"DIRECTION":"BI","MASTER_ID":55528,"compounds":"H(+) + H2O + L-tyrosine + O2 <=> (4-hydroxyphenyl)acetaldehyde + CO2 + H2O2 + NH4(+)","pmd":45.022}
{"X":8041,"KEGG":"R11918","RHEA_ID":55535,"DIRECTION":"BI","MASTER_ID":55532,"compounds":"H(+) + H2O + L-phenylalanine + O2 <=> 2-phenylacetaldehyde + CO2 + H2O2 + NH4(+)","pmd":45.022}
{"X":8042,"KEGG":"R11919","RHEA_ID":53507,"DIRECTION":"BI","MASTER_ID":53504,"compounds":"5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + AH2 + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + 5-hydroxybenzimidazole + A + formate + 2 H(+) + L-methionine + NH4(+) + phosphate","pmd":147.035}
{"X":8043,"KEGG":"R11919","RHEA_ID":53507,"DIRECTION":"BI","MASTER_ID":53504,"compounds":"5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + AH2 + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + 5-hydroxybenzimidazole + A + formate + 2 H(+) + L-methionine + NH4(+) + phosphate","pmd":43.955}
{"X":8044,"KEGG":"R11920","RHEA_ID":55219,"DIRECTION":"BI","MASTER_ID":55216,"compounds":"all-trans-geranylgeranyl diphosphate <=> diphosphate + rhizathalene A","pmd":177.943}
{"X":8045,"KEGG":"R11921","RHEA_ID":54787,"DIRECTION":"BI","MASTER_ID":54784,"compounds":"Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide <=> Ni(2+) + pyridinium-3,5-bisthiocarboxylate mononucleotide","pmd":55.92}
{"X":8046,"KEGG":"R11922","RHEA_ID":55723,"DIRECTION":"BI","MASTER_ID":55720,"compounds":"17-(4-hydroxyphenyl)heptadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate","pmd":15.219}
{"X":8047,"KEGG":"R11922","RHEA_ID":55723,"DIRECTION":"BI","MASTER_ID":55720,"compounds":"17-(4-hydroxyphenyl)heptadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate","pmd":159.933}
{"X":8048,"KEGG":"R11923","RHEA_ID":55727,"DIRECTION":"BI","MASTER_ID":55724,"compounds":"17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)","pmd":344.272}
{"X":8049,"KEGG":"R11924","RHEA_ID":55731,"DIRECTION":"BI","MASTER_ID":55728,"compounds":"19-(4-hydroxyphenyl)nonadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate","pmd":159.933}
{"X":8050,"KEGG":"R11924","RHEA_ID":55731,"DIRECTION":"BI","MASTER_ID":55728,"compounds":"19-(4-hydroxyphenyl)nonadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate","pmd":43.25}
{"X":8051,"KEGG":"R11925","RHEA_ID":55735,"DIRECTION":"BI","MASTER_ID":55732,"compounds":"19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)","pmd":372.303}
{"X":8052,"KEGG":"R11926","RHEA_ID":54751,"DIRECTION":"BI","MASTER_ID":54748,"compounds":"ATP + CoA + firefly L-luciferin <=> AMP + diphosphate + L-firefly luciferyl-CoA","pmd":159.933}
{"X":8053,"KEGG":"R11926","RHEA_ID":54751,"DIRECTION":"BI","MASTER_ID":54748,"compounds":"ATP + CoA + firefly L-luciferin <=> AMP + diphosphate + L-firefly luciferyl-CoA","pmd":420.052}
{"X":8054,"KEGG":"R11926","RHEA_ID":54751,"DIRECTION":"BI","MASTER_ID":54748,"compounds":"ATP + CoA + firefly L-luciferin <=> AMP + diphosphate + L-firefly luciferyl-CoA","pmd":67.066}
{"X":8055,"KEGG":"R11927","RHEA_ID":55151,"DIRECTION":"BI","MASTER_ID":55148,"compounds":"a [(3S)-4-alkanoyl-5-oxooxolan-3-yl]methyl phosphate + NADP(+) <=> a (4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate + H(+) + NADPH"}
{"X":8056,"KEGG":"R11928","RHEA_ID":55747,"DIRECTION":"BI","MASTER_ID":55744,"compounds":"coenzyme B + coenzyme M + 4 H(+) + 2 oxidized coenzyme F420-(gamma-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin] <=> coenzyme M-coenzyme B heterodisulfide + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 reduced coenzyme F420-(gamma-Glu)(n)","pmd":139.96}
{"X":8057,"KEGG":"R11928","RHEA_ID":55747,"DIRECTION":"BI","MASTER_ID":55744,"compounds":"coenzyme B + coenzyme M + 4 H(+) + 2 oxidized coenzyme F420-(gamma-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin] <=> coenzyme M-coenzyme B heterodisulfide + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 reduced coenzyme F420-(gamma-Glu)(n)","pmd":2.016}
{"X":8058,"KEGG":"R11928","RHEA_ID":55747,"DIRECTION":"BI","MASTER_ID":55744,"compounds":"coenzyme B + coenzyme M + 4 H(+) + 2 oxidized coenzyme F420-(gamma-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin] <=> coenzyme M-coenzyme B heterodisulfide + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 reduced coenzyme F420-(gamma-Glu)(n)","pmd":341.07}
{"X":8059,"KEGG":"R11929","RHEA_ID":55159,"DIRECTION":"BI","MASTER_ID":55156,"compounds":"a quinone + glutathione + H(+) + hydrogen sulfide <=> a quinol + S-sulfanylglutathione","pmd":31.972}
{"X":8060,"KEGG":"R11930","RHEA_ID":55767,"DIRECTION":"BI","MASTER_ID":55764,"compounds":"1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O <=> 2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol","pmd":18.011}
{"X":8061,"KEGG":"R11931","RHEA_ID":55163,"DIRECTION":"BI","MASTER_ID":55160,"metacyc":"RXN-18520","compounds":"coenzyme B + coenzyme M + 2 oxidized [2Fe-2S]-[ferredoxin] <=> coenzyme M-coenzyme B heterodisulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]","pmd":139.96}
{"X":8062,"KEGG":"R11931","RHEA_ID":55163,"DIRECTION":"BI","MASTER_ID":55160,"metacyc":"RXN-18520","compounds":"coenzyme B + coenzyme M + 2 oxidized [2Fe-2S]-[ferredoxin] <=> coenzyme M-coenzyme B heterodisulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]","pmd":341.07}
{"X":8063,"KEGG":"R11933","RHEA_ID":55567,"DIRECTION":"BI","MASTER_ID":55564,"compounds":"4-hydroxytryptamine + ATP <=> 4-hydoxytryptamine 4-phosphate + ADP + H(+)","pmd":79.966}
{"X":8064,"KEGG":"R11934","RHEA_ID":55571,"DIRECTION":"BI","MASTER_ID":55568,"compounds":"4-hydoxytryptamine 4-phosphate + 2 S-adenosyl-L-methionine <=> 2 H(+) + psilocybin + 2 S-adenosyl-L-homocysteine","pmd":14.016}
{"X":8065,"KEGG":"R11934","RHEA_ID":55571,"DIRECTION":"BI","MASTER_ID":55568,"compounds":"4-hydoxytryptamine 4-phosphate + 2 S-adenosyl-L-methionine <=> 2 H(+) + psilocybin + 2 S-adenosyl-L-homocysteine","pmd":28.031}
{"X":8066,"KEGG":"R11935","RHEA_ID":55575,"DIRECTION":"BI","MASTER_ID":55572,"compounds":"4-hydoxytryptamine 4-phosphate + S-adenosyl-L-methionine <=> 4-hydroxy-N-methyltryptamine 4-phosphate + H(+) + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":8067,"KEGG":"R11936","RHEA_ID":55579,"DIRECTION":"BI","MASTER_ID":55576,"compounds":"4-hydroxy-N-methyltryptamine 4-phosphate + S-adenosyl-L-methionine <=> H(+) + psilocybin + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":8068,"KEGG":"R11937","RHEA_ID":53319,"DIRECTION":"BI","MASTER_ID":53316,"compounds":"GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol <=> alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,poly-cis-undecaprenol + GDP + H(+)","pmd":162.053}
{"X":8069,"KEGG":"R11938","RHEA_ID":53323,"DIRECTION":"BI","MASTER_ID":53320,"compounds":"alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,poly-cis-undecaprenol + 2 GDP-alpha-D-mannose <=> alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,polycis-undecaprenol + 2 GDP + 2 H(+)","pmd":162.053}
{"X":8070,"KEGG":"R11939","RHEA_ID":52047,"DIRECTION":"BI","MASTER_ID":52044,"compounds":"mogrol + UDP-alpha-D-glucose <=> H(+) + mogroside IE + UDP","pmd":72.384}
{"X":8071,"KEGG":"R11940","RHEA_ID":55523,"DIRECTION":"BI","MASTER_ID":55520,"compounds":"dimethylallyl diphosphate + 3 isopentenyl diphosphate <=> 3 diphosphate + nerylneryl diphosphate","pmd":204.188}
{"X":8072,"KEGG":"R11941","RHEA_ID":55583,"DIRECTION":"BI","MASTER_ID":55580,"compounds":"ATP + H2O + L-glutamine <=> AMP + 2 H(+) + N(5)-phospho-L-glutamine + phosphate","pmd":159.933}
{"X":8073,"KEGG":"R11941","RHEA_ID":55583,"DIRECTION":"BI","MASTER_ID":55580,"compounds":"ATP + H2O + L-glutamine <=> AMP + 2 H(+) + N(5)-phospho-L-glutamine + phosphate","pmd":79.966}
{"X":8074,"KEGG":"R11942","RHEA_ID":55743,"DIRECTION":"BI","MASTER_ID":55740,"compounds":"H2O + oleuropein <=> D-glucose + oleuropein aglycone","pmd":162.053}
{"X":8075,"KEGG":"R11943","RHEA_ID":55751,"DIRECTION":"BI","MASTER_ID":55748,"compounds":"coenzyme B + coenzyme M + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> coenzyme M-coenzyme B heterodisulfide + 2 H2 + 2 oxidized [2Fe-2S]-[ferredoxin]","pmd":139.96}
{"X":8076,"KEGG":"R11943","RHEA_ID":55751,"DIRECTION":"BI","MASTER_ID":55748,"compounds":"coenzyme B + coenzyme M + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> coenzyme M-coenzyme B heterodisulfide + 2 H2 + 2 oxidized [2Fe-2S]-[ferredoxin]","pmd":341.07}
{"X":8077,"KEGG":"R11943","RHEA_ID":55755,"DIRECTION":"BI","MASTER_ID":55752,"compounds":"2 CO2 + coenzyme B + coenzyme M + 2 reduced [2Fe-2S]-[ferredoxin] <=> coenzyme M-coenzyme B heterodisulfide + 2 formate + 2 oxidized [2Fe-2S]-[ferredoxin]","pmd":139.96}
{"X":8078,"KEGG":"R11943","RHEA_ID":55755,"DIRECTION":"BI","MASTER_ID":55752,"compounds":"2 CO2 + coenzyme B + coenzyme M + 2 reduced [2Fe-2S]-[ferredoxin] <=> coenzyme M-coenzyme B heterodisulfide + 2 formate + 2 oxidized [2Fe-2S]-[ferredoxin]","pmd":341.07}
{"X":8079,"KEGG":"R11945","RHEA_ID":29094,"DIRECTION":"BI","MASTER_ID":29091,"ecocyc":"NADH-DEHYDROG-A-RXN","metacyc":"NADH-DEHYDROG-A-RXN","compounds":"a ubiquinone + 5 H(+)(in) + NADH <=> a ubiquinol + 4 H(+)(out) + NAD(+)"}
{"X":8080,"KEGG":"R11946","RHEA_ID":13064,"DIRECTION":"BI","MASTER_ID":13061,"compounds":"O2 + S-sulfanylglutathione <=> glutathione S,S-dioxide + H(+)","pmd":31.99}
{"X":8081,"KEGG":"R11947","RHEA_ID":28658,"DIRECTION":"BI","MASTER_ID":28655,"compounds":"glutathione S,S-dioxide + H2O <=> glutathione + H(+) + sulfite","pmd":63.962}
{"X":8082,"KEGG":"R11948","RHEA_ID":55759,"DIRECTION":"BI","MASTER_ID":55756,"compounds":"2-oxoglutarate + an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + O2 <=> a 2-hydroxyornithine lipid + CO2 + succinate","pmd":27.995}
{"X":8083,"KEGG":"R11949","RHEA_ID":55427,"DIRECTION":"BI","MASTER_ID":55424,"compounds":"(3S,6E)-nerolidol + O2 + reduced [NADPH--hemoprotein reductase] <=> (3E)-4,8-dimethylnona-1,3,7-triene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]","pmd":72.058}
{"X":8084,"KEGG":"R11951","RHEA_ID":55431,"DIRECTION":"BI","MASTER_ID":55428,"compounds":"ferruginol + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-hydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":8085,"KEGG":"R11953","RHEA_ID":52811,"DIRECTION":"BI","MASTER_ID":52808,"compounds":"adenosine in U6 snRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine in U6 snRNA + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":8086,"KEGG":"R11955","RHEA_ID":41014,"DIRECTION":"BI","MASTER_ID":41011,"compounds":"(+)-sesamin + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n <=> (+)-sesamin monocatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n)","pmd":12}
{"X":8087,"KEGG":"R11956","RHEA_ID":52379,"DIRECTION":"BI","MASTER_ID":52376,"compounds":"(+)-sesamin monocatechol + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n <=> (+)-sesamin dicatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n)","pmd":12}
{"X":8088,"KEGG":"R11957","RHEA_ID":55975,"DIRECTION":"BI","MASTER_ID":55972,"compounds":"acetyl-CoA + ethanol <=> CoA + ethyl acetate","pmd":42.011}
{"X":8089,"KEGG":"R11958","RHEA_ID":55983,"DIRECTION":"BI","MASTER_ID":55980,"compounds":"1,2-saturated acyl-CoA + an acyl-CoA + H2O <=> an (R)-2-alkyl-3-oxoalkanoate + 2 CoA + H(+)"}
{"X":8090,"KEGG":"R11960","RHEA_ID":54995,"DIRECTION":"BI","MASTER_ID":54992,"compounds":"3 A + FMN + H2O + L-glutamate + O2 <=> 2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 3 AH2 + CO2 + H(+)","pmd":1.032}
{"X":8091,"KEGG":"R11960","RHEA_ID":54995,"DIRECTION":"BI","MASTER_ID":54992,"compounds":"3 A + FMN + H2O + L-glutamate + O2 <=> 2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 3 AH2 + CO2 + H(+)","pmd":0.995}
{"X":8092,"KEGG":"R11964","RHEA_ID":56307,"DIRECTION":"BI","MASTER_ID":56304,"compounds":"ATP + H2O + rifampicin <=> 21-phosphorifampicin + AMP + 2 H(+) + phosphate","pmd":159.933}
{"X":8093,"KEGG":"R11964","RHEA_ID":56307,"DIRECTION":"BI","MASTER_ID":56304,"compounds":"ATP + H2O + rifampicin <=> 21-phosphorifampicin + AMP + 2 H(+) + phosphate","pmd":79.966}
{"X":8094,"KEGG":"R11971","RHEA_ID":16996,"DIRECTION":"BI","MASTER_ID":16993,"compounds":"6 [Fe(III)cytochrome c] + 3 H2O + S-disulfanyl-L-cysteinyl-[SoxY protein] <=> 6 [Fe(II)cytochrome c] + 7 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]"}
{"X":8095,"KEGG":"R11973","RHEA_ID":55435,"DIRECTION":"BI","MASTER_ID":55432,"compounds":"11-hydroxyferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> carnosate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]","pmd":29.974}
{"X":8096,"KEGG":"R11974","RHEA_ID":55439,"DIRECTION":"BI","MASTER_ID":55436,"compounds":"ferruginol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + salviol","pmd":15.995}
{"X":8097,"KEGG":"R11975","RHEA_ID":55443,"DIRECTION":"BI","MASTER_ID":55440,"compounds":"beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + maniladiol + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":8098,"KEGG":"R11976","RHEA_ID":55455,"DIRECTION":"BI","MASTER_ID":55452,"compounds":"beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> daturadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":8099,"KEGG":"R11977","RHEA_ID":55459,"DIRECTION":"BI","MASTER_ID":55456,"compounds":"ferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + sugiol","pmd":13.979}
{"X":8100,"KEGG":"R11979","RHEA_ID":55467,"DIRECTION":"BI","MASTER_ID":55464,"compounds":"11-hydroxysugiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 11,20-dihydroxysugiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":8101,"KEGG":"R11980","RHEA_ID":55475,"DIRECTION":"BI","MASTER_ID":55472,"compounds":"9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> 9beta-pimara-7,15-diene-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":8102,"KEGG":"R11981","RHEA_ID":55483,"DIRECTION":"BI","MASTER_ID":55480,"compounds":"ent-cassa-12,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> ent-3beta-hydroxycassa-12,15-dien-2-one + 3 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]","pmd":29.974}
{"X":8103,"KEGG":"R11982","RHEA_ID":55487,"DIRECTION":"BI","MASTER_ID":55484,"compounds":"ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-cassa-12,15-dien-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":8104,"KEGG":"R11983","RHEA_ID":55491,"DIRECTION":"BI","MASTER_ID":55488,"compounds":"ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-cassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]","pmd":2.016}
{"X":8105,"KEGG":"R11984","RHEA_ID":55495,"DIRECTION":"BI","MASTER_ID":55492,"compounds":"ent-cassa-12,15-dien-2-one + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":8106,"KEGG":"R11985","RHEA_ID":55499,"DIRECTION":"BI","MASTER_ID":55496,"compounds":"ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-cassa-12,15-dien-2beta,3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":8107,"KEGG":"R11986","RHEA_ID":55503,"DIRECTION":"BI","MASTER_ID":55500,"compounds":"ent-cassa-12,15-dien-2beta,3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]","pmd":2.016}
{"X":8108,"KEGG":"R11987","RHEA_ID":55471,"DIRECTION":"BI","MASTER_ID":55468,"compounds":"11-hydroxyferruginol + O2 + reduced [NADPH--hemoprotein reductase] <=> 11,20-dihydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":8109,"KEGG":"R11990","RHEA_ID":55463,"DIRECTION":"BI","MASTER_ID":55460,"compounds":"11-hydroxyferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 11-hydroxysugiol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]","pmd":13.979}
{"X":8110,"KEGG":"R11999","RHEA_ID":55923,"DIRECTION":"BI","MASTER_ID":55920,"compounds":"[cis-1,4-isoprene](n) + O2 <=> (4Z,8Z)-4,8-dimethyl-12-oxotrideca-4,8-dienal + cis-1,4-isoprene(n-3)"}
{"X":8111,"KEGG":"R12000","RHEA_ID":19096,"DIRECTION":"BI","MASTER_ID":19093,"compounds":"2 H(+) + siroheme <=> 12,18-didecarboxysiroheme + 2 CO2","pmd":87.98}
{"X":8112,"KEGG":"R12003","RHEA_ID":12732,"DIRECTION":"BI","MASTER_ID":12729,"metacyc":"RXN-19294","compounds":"lutein <=> (3R,3'S)-zeaxanthin","pmd":0}
{"X":8113,"KEGG":"R12004","RHEA_ID":30666,"DIRECTION":"BI","MASTER_ID":30663,"compounds":"3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole <=> hapalindole H","pmd":0}
{"X":8114,"KEGG":"R12005","RHEA_ID":56455,"DIRECTION":"BI","MASTER_ID":56452,"compounds":"3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole <=> 12-epi-hapalindole U","pmd":0}
{"X":8115,"KEGG":"R12006","RHEA_ID":56459,"DIRECTION":"BI","MASTER_ID":56456,"compounds":"3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole <=> 12-epi-fischerindole U","pmd":0}
{"X":8116,"KEGG":"R12007","RHEA_ID":55511,"DIRECTION":"BI","MASTER_ID":55508,"compounds":"cucurbitadienol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 11-oxocucurbitadienol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]","pmd":13.979}
{"X":8117,"KEGG":"R12008","RHEA_ID":55515,"DIRECTION":"BI","MASTER_ID":55512,"compounds":"cucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-hydroxycucurbitadienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":8118,"KEGG":"R12009","RHEA_ID":55519,"DIRECTION":"BI","MASTER_ID":55516,"compounds":"11-hydroxycucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-oxocucurbitadienol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]","pmd":2.016}
{"X":8119,"KEGG":"R12010","RHEA_ID":55507,"DIRECTION":"BI","MASTER_ID":55504,"compounds":"(5S,9S,10S)-drim-7-en-11-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> (5S,10S)-(9R)-7-drimene-11,12-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":8120,"KEGG":"R12011","RHEA_ID":55587,"DIRECTION":"BI","MASTER_ID":55584,"compounds":"adenosine in mRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine in mRNA + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":8121,"KEGG":"R12012","RHEA_ID":11403,"DIRECTION":"BI","MASTER_ID":11400,"compounds":"GDP-6-deoxy-alpha-D-altrose + sordaricin <=> 4'-O-demethylsordarin + GDP + H(+)","pmd":110.825}
{"X":8122,"KEGG":"R12013","RHEA_ID":56351,"DIRECTION":"BI","MASTER_ID":56348,"compounds":"4-hydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 <=> 2,4-dibromophenol + CO2 + 4 H2O + 2 NADP(+)","pmd":111.831}
{"X":8123,"KEGG":"R12013","RHEA_ID":56351,"DIRECTION":"BI","MASTER_ID":56348,"compounds":"4-hydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 <=> 2,4-dibromophenol + CO2 + 4 H2O + 2 NADP(+)","pmd":495.228}
{"X":8124,"KEGG":"R12014","RHEA_ID":55675,"DIRECTION":"BI","MASTER_ID":55672,"compounds":"4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine <=> 4-O-([2-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP","pmd":203.079}
{"X":8125,"KEGG":"R12015","RHEA_ID":56355,"DIRECTION":"BI","MASTER_ID":56352,"compounds":"4-hydroxybenzoate + bromide + 2 H(+) + NADPH + O2 <=> 3-bromo-4-hydroxybenzoate + 2 H2O + NADP(+)","pmd":77.911}
{"X":8126,"KEGG":"R12015","RHEA_ID":56355,"DIRECTION":"BI","MASTER_ID":56352,"compounds":"4-hydroxybenzoate + bromide + 2 H(+) + NADPH + O2 <=> 3-bromo-4-hydroxybenzoate + 2 H2O + NADP(+)","pmd":529.149}
{"X":8127,"KEGG":"R12016","RHEA_ID":56359,"DIRECTION":"BI","MASTER_ID":56356,"compounds":"3-bromo-4-hydroxybenzoate + bromide + 3 H(+) + NADPH + O2 <=> 2,4-dibromophenol + CO2 + 2 H2O + NADP(+)","pmd":495.228}
{"X":8128,"KEGG":"R12016","RHEA_ID":56359,"DIRECTION":"BI","MASTER_ID":56356,"compounds":"3-bromo-4-hydroxybenzoate + bromide + 3 H(+) + NADPH + O2 <=> 2,4-dibromophenol + CO2 + 2 H2O + NADP(+)","pmd":33.921}
{"X":8129,"KEGG":"R12017","RHEA_ID":54759,"DIRECTION":"BI","MASTER_ID":54756,"compounds":"deamido-NAD(+) + hydrogencarbonate <=> AMP + 2 H(+) + pyridinium-3,5-dicarboxylate mononucleotide","pmd":285.063}
{"X":8130,"KEGG":"R12018","RHEA_ID":56371,"DIRECTION":"BI","MASTER_ID":56368,"compounds":"3,4-dihydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 <=> 3,5-dibromobenzene-1,2-diol + CO2 + 4 H2O + 2 NADP(+)","pmd":479.233}
{"X":8131,"KEGG":"R12018","RHEA_ID":56371,"DIRECTION":"BI","MASTER_ID":56368,"compounds":"3,4-dihydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 <=> 3,5-dibromobenzene-1,2-diol + CO2 + 4 H2O + 2 NADP(+)","pmd":111.831}
{"X":8132,"KEGG":"R12019","RHEA_ID":56375,"DIRECTION":"BI","MASTER_ID":56372,"compounds":"3,4-dihydroxybenzoate + bromide + 2 H(+) + NADPH + O2 <=> 3-bromo-4,5-dihydroxybenzoate + 2 H2O + NADP(+)","pmd":513.154}
{"X":8133,"KEGG":"R12019","RHEA_ID":56375,"DIRECTION":"BI","MASTER_ID":56372,"compounds":"3,4-dihydroxybenzoate + bromide + 2 H(+) + NADPH + O2 <=> 3-bromo-4,5-dihydroxybenzoate + 2 H2O + NADP(+)","pmd":77.91}
{"X":8134,"KEGG":"R12020","RHEA_ID":56379,"DIRECTION":"BI","MASTER_ID":56376,"compounds":"3-bromo-4,5-dihydroxybenzoate + bromide + 3 H(+) + NADPH + O2 <=> 3,5-dibromobenzene-1,2-diol + CO2 + 2 H2O + NADP(+)","pmd":479.233}
{"X":8135,"KEGG":"R12020","RHEA_ID":56379,"DIRECTION":"BI","MASTER_ID":56376,"compounds":"3-bromo-4,5-dihydroxybenzoate + bromide + 3 H(+) + NADPH + O2 <=> 3,5-dibromobenzene-1,2-diol + CO2 + 2 H2O + NADP(+)","pmd":33.921}
{"X":8136,"KEGG":"R12021","RHEA_ID":56387,"DIRECTION":"BI","MASTER_ID":56384,"compounds":"(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2 <=> (5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O","pmd":2.016}
{"X":8137,"KEGG":"R12022","RHEA_ID":56391,"DIRECTION":"BI","MASTER_ID":56388,"compounds":"(5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2 <=> (4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O","pmd":2.016}
{"X":8138,"KEGG":"R12023","RHEA_ID":56383,"DIRECTION":"BI","MASTER_ID":56380,"compounds":"(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 chloride + 2 FADH2 + 2 O2 <=> (4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 FAD + 4 H2O","pmd":2.016}
{"X":8139,"KEGG":"R12024","RHEA_ID":54535,"DIRECTION":"BI","MASTER_ID":54532,"compounds":"H2O + N-(4-oxoglutaryl)-L-cysteinylglycine <=> 2-oxoglutarate + L-cysteinylglycine","pmd":128.011}
{"X":8140,"KEGG":"R12026","RHEA_ID":55707,"DIRECTION":"BI","MASTER_ID":55704,"compounds":"glycine + hydrogen sulfide + NAD(+) <=> ADP-5-ethyl-4-methylthiazole-2-carboxylate + H(+) + 3 H2O + nicotinamide","pmd":68.068}
{"X":8141,"KEGG":"R12027","RHEA_ID":56475,"DIRECTION":"BI","MASTER_ID":56472,"compounds":"(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 <=> (5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O","pmd":2.016}
{"X":8142,"KEGG":"R12028","RHEA_ID":56479,"DIRECTION":"BI","MASTER_ID":56476,"compounds":"(5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 <=> (4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O","pmd":2.016}
{"X":8143,"KEGG":"R12029","RHEA_ID":56483,"DIRECTION":"BI","MASTER_ID":56480,"compounds":"(4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 <=> (3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O","pmd":2.016}
{"X":8144,"KEGG":"R12030","RHEA_ID":56471,"DIRECTION":"BI","MASTER_ID":56468,"compounds":"(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 bromide + 3 FADH2 + 3 O2 <=> (3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 FAD + 6 H2O","pmd":2.016}
{"X":8145,"KEGG":"R12031","RHEA_ID":55899,"DIRECTION":"BI","MASTER_ID":55896,"compounds":"chloride + FADH2 + L-tryptophan + O2 <=> 5-chloro-L-tryptophan + FAD + 2 H2O","pmd":33.961}
{"X":8146,"KEGG":"R12031","RHEA_ID":55899,"DIRECTION":"BI","MASTER_ID":55896,"compounds":"chloride + FADH2 + L-tryptophan + O2 <=> 5-chloro-L-tryptophan + FAD + 2 H2O","pmd":2.016}
{"X":8147,"KEGG":"R12033","RHEA_ID":56531,"DIRECTION":"BI","MASTER_ID":56528,"compounds":"chloride + D-tryptophan + FADH2 + O2 <=> 6-chloro-D-tryptophan + FAD + 2 H2O","pmd":33.961}
{"X":8148,"KEGG":"R12033","RHEA_ID":56531,"DIRECTION":"BI","MASTER_ID":56528,"compounds":"chloride + D-tryptophan + FADH2 + O2 <=> 6-chloro-D-tryptophan + FAD + 2 H2O","pmd":2.016}
{"X":8149,"KEGG":"R12034","RHEA_ID":55907,"DIRECTION":"BI","MASTER_ID":55904,"compounds":"7-chloro-L-tryptophan + chloride + FADH2 + O2 <=> 6,7-dichloro-L-tryptophan + FAD + 2 H2O","pmd":33.961}
{"X":8150,"KEGG":"R12034","RHEA_ID":55907,"DIRECTION":"BI","MASTER_ID":55904,"compounds":"7-chloro-L-tryptophan + chloride + FADH2 + O2 <=> 6,7-dichloro-L-tryptophan + FAD + 2 H2O","pmd":2.016}
{"X":8151,"KEGG":"R12035","RHEA_ID":55875,"DIRECTION":"BI","MASTER_ID":55872,"compounds":"anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) <=> 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH","pmd":133.016}
{"X":8152,"KEGG":"R12035","RHEA_ID":55875,"DIRECTION":"BI","MASTER_ID":55872,"compounds":"anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) <=> 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH","pmd":395}
{"X":8153,"KEGG":"R12035","RHEA_ID":55875,"DIRECTION":"BI","MASTER_ID":55872,"compounds":"anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) <=> 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH","pmd":132.069}
{"X":8154,"KEGG":"R12036","RHEA_ID":10071,"DIRECTION":"BI","MASTER_ID":10068,"compounds":"4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-alpha-D-glucose <=> 4-O-[(2-beta-D-glucosyl-D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP","pmd":162.053}
{"X":8155,"KEGG":"R12056","RHEA_ID":11659,"DIRECTION":"BI","MASTER_ID":11656,"compounds":"ATP + holo-[peptidyl-carrier protein] + L-proline <=> AMP + diphosphate + L-prolyl-[peptidyl-carrier protein]","pmd":62.88}
{"X":8156,"KEGG":"R12056","RHEA_ID":11659,"DIRECTION":"BI","MASTER_ID":11656,"compounds":"ATP + holo-[peptidyl-carrier protein] + L-proline <=> AMP + diphosphate + L-prolyl-[peptidyl-carrier protein]","pmd":329.053}
{"X":8157,"KEGG":"R12067","RHEA_ID":50911,"DIRECTION":"BI","MASTER_ID":50908,"compounds":"a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 <=> A + a 3-demethylubiquinol + H2O"}
{"X":8158,"KEGG":"R12068","RHEA_ID":55927,"DIRECTION":"BI","MASTER_ID":55924,"compounds":"albendazole + O2 + reduced [NADPH--hemoprotein reductase] <=> albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":8159,"KEGG":"R12068","RHEA_ID":55931,"DIRECTION":"BI","MASTER_ID":55928,"compounds":"fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] <=> fenbendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":8160,"KEGG":"R12070","RHEA_ID":56291,"DIRECTION":"BI","MASTER_ID":56288,"compounds":"albendazole + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + hydroxyalbendazole + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":8161,"KEGG":"R12071","RHEA_ID":56295,"DIRECTION":"BI","MASTER_ID":56292,"compounds":"fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] <=> 4'-hydroxyfenbendazole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":8162,"KEGG":"R12074","RHEA_ID":56687,"DIRECTION":"BI","MASTER_ID":56684,"compounds":"dihydrorhizobitoxine + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + rhizobitoxine","pmd":2.016}
{"X":8163,"KEGG":"R12076","RHEA_ID":56695,"DIRECTION":"BI","MASTER_ID":56692,"compounds":"(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 <=> 4-[(E)-2-isocyanoethenyl]phenol + 2 CO2 + H2O + succinate","pmd":0.969}
{"X":8164,"KEGG":"R12076","RHEA_ID":56695,"DIRECTION":"BI","MASTER_ID":56692,"compounds":"(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 <=> 4-[(E)-2-isocyanoethenyl]phenol + 2 CO2 + H2O + succinate","pmd":46.005}
{"X":8165,"KEGG":"R12081","RHEA_ID":56691,"DIRECTION":"BI","MASTER_ID":56688,"compounds":"(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + O2 <=> (2E)-3-(4-hydroxyphenyl)-2-isocyanoprop-2-enoate + CO2 + H2O + succinate","pmd":27.995}
{"X":8166,"KEGG":"R12081","RHEA_ID":56691,"DIRECTION":"BI","MASTER_ID":56688,"compounds":"(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + O2 <=> (2E)-3-(4-hydroxyphenyl)-2-isocyanoprop-2-enoate + CO2 + H2O + succinate","pmd":2.016}
{"X":8167,"KEGG":"R12082","RHEA_ID":56703,"DIRECTION":"BI","MASTER_ID":56700,"compounds":"(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 <=> 3-[(Z)-2-isocyanoethenyl]-1H-indole + 2 CO2 + H2O + succinate","pmd":22.047}
{"X":8168,"KEGG":"R12082","RHEA_ID":56703,"DIRECTION":"BI","MASTER_ID":56700,"compounds":"(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 <=> 3-[(Z)-2-isocyanoethenyl]-1H-indole + 2 CO2 + H2O + succinate","pmd":46.005}
{"X":8169,"KEGG":"R12083","RHEA_ID":56707,"DIRECTION":"BI","MASTER_ID":56704,"compounds":"(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 <=> 3-[(E)-2-isocyanovinyl]indole + 2 CO2 + H2O + succinate","pmd":22.047}
{"X":8170,"KEGG":"R12083","RHEA_ID":56707,"DIRECTION":"BI","MASTER_ID":56704,"compounds":"(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 <=> 3-[(E)-2-isocyanovinyl]indole + 2 CO2 + H2O + succinate","pmd":46.005}
{"X":8171,"KEGG":"R12084","RHEA_ID":55543,"DIRECTION":"BI","MASTER_ID":55540,"compounds":"40 ATP + 40 H2O + N2 + 12 reduced [2Fe-2S]-[ferredoxin] <=> 40 ADP + 26 H(+) + 3 H2 + 2 NH4(+) + 12 oxidized [2Fe-2S]-[ferredoxin] + 40 phosphate","pmd":79.966}
{"X":8172,"KEGG":"R12085","RHEA_ID":48235,"DIRECTION":"BI","MASTER_ID":48232,"compounds":"acetyl-CoA + L-glutamate 5-semialdehyde <=> CoA + H(+) + N-acetyl-L-glutamate 5-semialdehyde","pmd":42.011}
{"X":8173,"KEGG":"R12087","RHEA_ID":48239,"DIRECTION":"BI","MASTER_ID":48236,"compounds":"2 2-acetylphloroglucinol <=> 1,3,5-trihydroxybenzene + 2,4-diacetylphloroglucinol + H(+)","pmd":42.01}
{"X":8174,"KEGG":"R12088","RHEA_ID":51579,"DIRECTION":"BI","MASTER_ID":51576,"compounds":"phloretin + UDP-alpha-D-glucose <=> H(+) + phlorizin + UDP","pmd":129.918}
{"X":8175,"KEGG":"R12089","RHEA_ID":17352,"DIRECTION":"BI","MASTER_ID":17349,"compounds":"(2E)-geranyl diphosphate + 3-[(Z)-2-isocyanoethenyl]-1H-indole <=> 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole + diphosphate","pmd":136.125}
{"X":8176,"KEGG":"R12089","RHEA_ID":17352,"DIRECTION":"BI","MASTER_ID":17349,"compounds":"(2E)-geranyl diphosphate + 3-[(Z)-2-isocyanoethenyl]-1H-indole <=> 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole + diphosphate","pmd":9.875}
{"X":8177,"KEGG":"R12092","RHEA_ID":52423,"DIRECTION":"BI","MASTER_ID":52420,"compounds":"O-phospho-L-serine + thiosulfate <=> phosphate + S-sulfo-L-cysteine","pmd":15.968}
{"X":8178,"KEGG":"R12095","RHEA_ID":58459,"DIRECTION":"BI","MASTER_ID":58456,"compounds":"(2R)-2-O-(alpha-D-mannosyl)-glycerate + H2O <=> (R)-glycerate + D-mannose","pmd":88.016}
{"X":8179,"KEGG":"R12096","RHEA_ID":48267,"DIRECTION":"BI","MASTER_ID":48264,"compounds":"H2O + S-sulfosulfanyl-L-cysteinyl-[SoxY protein] <=> H(+) + S-sulfanyl-L-cysteinyl-[SoxY protein] + sulfate"}
{"X":8180,"KEGG":"R12097","RHEA_ID":56719,"DIRECTION":"BI","MASTER_ID":56716,"compounds":"H2O + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein] <=> H(+) + S-disulfanyl-L-cysteinyl-[SoxY protein] + sulfate"}
{"X":8181,"KEGG":"R12098","RHEA_ID":56143,"DIRECTION":"BI","MASTER_ID":56140,"compounds":"H2O + S-adenosyl-L-methionine <=> adenosine + H(+) + L-methionine","pmd":131.04}
{"X":8182,"KEGG":"R12099","RHEA_ID":56103,"DIRECTION":"BI","MASTER_ID":56100,"compounds":"[small archaeal modifier protein]-C-terminal Gly-Gly + ATP + H(+) <=> [small archaeal modifier protein]-C-terminal Gly-Gly-AMP + diphosphate"}
{"X":8183,"KEGG":"R12100","RHEA_ID":56163,"DIRECTION":"BI","MASTER_ID":56160,"compounds":"an archaeal dolichyl alpha-D-glucosyl phosphate + UDP-alpha-D-glucuronate <=> an archaeal dolichyl beta-D-glucuronosyl-(1->4)-alpha-D-glucosyl phosphate + H(+) + UDP","pmd":176.032}
{"X":8184,"KEGG":"R12105","RHEA_ID":31738,"DIRECTION":"BI","MASTER_ID":31735,"compounds":"3-oxocholan-24-oyl-CoA + NAD(+) <=> 3-oxochol-4-en-24-oyl-CoA + H(+) + NADH"}
{"X":8185,"KEGG":"R12106","RHEA_ID":56651,"DIRECTION":"BI","MASTER_ID":56648,"compounds":"3-oxochol-4-en-24-oyl-CoA + NAD(+) <=> 3-oxochol-4,6-dien-24-oyl-CoA + H(+) + NADH"}
{"X":8186,"KEGG":"R12107","RHEA_ID":56655,"DIRECTION":"BI","MASTER_ID":56652,"compounds":"12alpha-hydroxy-3-oxocholan-24-oyl-CoA + NAD(+) <=> 12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH"}
{"X":8187,"KEGG":"R12108","RHEA_ID":56659,"DIRECTION":"BI","MASTER_ID":56656,"compounds":"12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NAD(+) <=> 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H(+) + NADH"}
{"X":8188,"KEGG":"R12112","RHEA_ID":56675,"DIRECTION":"BI","MASTER_ID":56672,"compounds":"dihydro-4-coumaroyl-CoA + NADP(+) <=> (E)-4-coumaroyl-CoA + H(+) + NADPH","pmd":2.016}
{"X":8189,"KEGG":"R12112","RHEA_ID":56675,"DIRECTION":"BI","MASTER_ID":56672,"compounds":"dihydro-4-coumaroyl-CoA + NADP(+) <=> (E)-4-coumaroyl-CoA + H(+) + NADPH","pmd":169.069}
{"X":8190,"KEGG":"R12113","RHEA_ID":56679,"DIRECTION":"BI","MASTER_ID":56676,"compounds":"dihydroferuloyl-CoA + NADP(+) <=> (E)-feruloyl-CoA + H(+) + NADPH","pmd":2.016}
{"X":8191,"KEGG":"R12113","RHEA_ID":56679,"DIRECTION":"BI","MASTER_ID":56676,"compounds":"dihydroferuloyl-CoA + NADP(+) <=> (E)-feruloyl-CoA + H(+) + NADPH","pmd":199.079}
{"X":8192,"KEGG":"R12128","RHEA_ID":30306,"DIRECTION":"BI","MASTER_ID":30303,"compounds":"(+)-(R)-germacrene A + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> germacra-1(10),4,11(13)-trien-12-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]","pmd":29.974}
{"X":8193,"KEGG":"R12129","RHEA_ID":61315,"DIRECTION":"BI","MASTER_ID":61312,"compounds":"germacra-1(10),4,11(13)-trien-12-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> germacra-1(10),4,11(13)-trien-12-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]","pmd":2.016}
{"X":8194,"KEGG":"R12130","RHEA_ID":61319,"DIRECTION":"BI","MASTER_ID":61316,"compounds":"germacra-1(10),4,11(13)-trien-12-al + O2 + reduced [NADPH--hemoprotein reductase] <=> germacra-1(10),4,11(13)-trien-12-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":8195,"KEGG":"R12131","RHEA_ID":56991,"DIRECTION":"BI","MASTER_ID":56988,"compounds":"germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]","pmd":15.995}
{"X":8196,"KEGG":"R12132","RHEA_ID":56995,"DIRECTION":"BI","MASTER_ID":56992,"compounds":"6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) <=> (+)-costunolide + H2O","pmd":18.011}
{"X":8197,"KEGG":"R12151","RHEA_ID":56699,"DIRECTION":"BI","MASTER_ID":56696,"compounds":"D-ribulose 5-phosphate + L-tryptophan <=> (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate","pmd":9.984}
{"X":8198,"KEGG":"R12151","RHEA_ID":56699,"DIRECTION":"BI","MASTER_ID":56696,"compounds":"D-ribulose 5-phosphate + L-tryptophan <=> (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate","pmd":15.945}
{"X":8199,"KEGG":"R12157","RHEA_ID":56851,"DIRECTION":"BI","MASTER_ID":56848,"compounds":"1,6-didemethyltoxoflavin + S-adenosyl-L-methionine <=> H(+) + reumycin + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":8200,"KEGG":"R12158","RHEA_ID":56855,"DIRECTION":"BI","MASTER_ID":56852,"compounds":"reumycin + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + toxoflavin","pmd":14.016}
{"X":8201,"KEGG":"R12160","RHEA_ID":56075,"DIRECTION":"BI","MASTER_ID":56072,"compounds":"a 2-acylphloroglucinol + UDP-alpha-D-glucose <=> a 2-acylphloroglucinol 1-O-beta-D-glucoside + UDP","pmd":162.053}
{"X":8202,"KEGG":"R12165","RHEA_ID":57359,"DIRECTION":"BI","MASTER_ID":57356,"compounds":"2-oxoglutarate + chloride + H(+) + hapalindole U + O2 <=> CO2 + H2O + hapalindole G + succinate","pmd":27.995}
{"X":8203,"KEGG":"R12165","RHEA_ID":57359,"DIRECTION":"BI","MASTER_ID":57356,"compounds":"2-oxoglutarate + chloride + H(+) + hapalindole U + O2 <=> CO2 + H2O + hapalindole G + succinate","pmd":33.961}
{"X":8204,"KEGG":"R12166","RHEA_ID":56767,"DIRECTION":"BI","MASTER_ID":56764,"compounds":"12-epi-fischerindole U + 2-oxoglutarate + chloride + H(+) + O2 <=> 12-epi-fischerindole G + CO2 + H2O + succinate","pmd":27.995}
{"X":8205,"KEGG":"R12166","RHEA_ID":56767,"DIRECTION":"BI","MASTER_ID":56764,"compounds":"12-epi-fischerindole U + 2-oxoglutarate + chloride + H(+) + O2 <=> 12-epi-fischerindole G + CO2 + H2O + succinate","pmd":33.961}
{"X":8206,"KEGG":"R12176","RHEA_ID":56815,"DIRECTION":"BI","MASTER_ID":56812,"compounds":"2-oxoglutarate + chloride + H(+) + L-threonyl-[peptidyl-carrier protein] + O2 <=> 4-chloro-L-threonyl-[peptidyl-carrier protein] + CO2 + H2O + succinate","pmd":27.995}
{"X":8207,"KEGG":"R12177","RHEA_ID":56823,"DIRECTION":"BI","MASTER_ID":56820,"compounds":"AH2 + cyclooctat-9-en-7-ol + O2 <=> A + cyclooctat-9-ene-5,7-diol + H2O","pmd":15.995}
{"X":8208,"KEGG":"R12178","RHEA_ID":56827,"DIRECTION":"BI","MASTER_ID":56824,"compounds":"AH2 + cyclooctat-9-ene-5,7-diol + O2 <=> A + cyclooctatin + H2O","pmd":15.995}
{"X":8209,"KEGG":"R12214","RHEA_ID":61627,"DIRECTION":"BI","MASTER_ID":61624,"compounds":"2-oxoglutarate + cadaverine <=> 5-aminopentanal + L-glutamate","pmd":1.032}
{"X":8210,"KEGG":"R12215","RHEA_ID":61635,"DIRECTION":"BI","MASTER_ID":61632,"compounds":"5-aminopentanal + H2O + NAD(+) <=> 5-aminopentanoate + 2 H(+) + NADH","pmd":547.038}
{"X":8211,"KEGG":"R12215","RHEA_ID":61635,"DIRECTION":"BI","MASTER_ID":61632,"compounds":"5-aminopentanal + H2O + NAD(+) <=> 5-aminopentanoate + 2 H(+) + NADH","pmd":15.995}
{"X":8212,"KEGG":"R12216","RHEA_ID":13824,"DIRECTION":"BI","MASTER_ID":13821,"compounds":"2-oxoglutarate + glutarate + O2 <=> (S)-2-hydroxyglutarate + CO2 + succinate","pmd":14.016}
{"X":8213,"KEGG":"R12216","RHEA_ID":13824,"DIRECTION":"BI","MASTER_ID":13821,"compounds":"2-oxoglutarate + glutarate + O2 <=> (S)-2-hydroxyglutarate + CO2 + succinate","pmd":2.016}
{"X":8214,"KEGG":"R12217","RHEA_ID":58667,"DIRECTION":"BI","MASTER_ID":58664,"compounds":"(S)-2-hydroxyglutarate + a quinone <=> 2-oxoglutarate + a quinol","pmd":2.016}
{"X":8215,"KEGG":"R12238","RHEA_ID":13344,"DIRECTION":"BI","MASTER_ID":13341,"compounds":"a menaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine <=> 5'-deoxyadenosine + an 8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":8216,"KEGG":"R12239","RHEA_ID":57703,"DIRECTION":"BI","MASTER_ID":57700,"compounds":"a 2-demethylmenaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine <=> 5'-deoxyadenosine + a 2-demethyl-8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine","pmd":14.016}
{"X":8217,"KEGG":"R12258","RHEA_ID":58163,"DIRECTION":"BI","MASTER_ID":58160,"compounds":"ent-copalyl diphosphate <=> diphosphate + dolabradiene","pmd":177.943}
{"X":8218,"KEGG":"R12259","RHEA_ID":58167,"DIRECTION":"BI","MASTER_ID":58164,"compounds":"(2E,6E)-farnesyl diphosphate + 2 H2O <=> 7-epi-ent-eudesmane-5,11-diol + diphosphate","pmd":141.922}
{"X":8219,"KEGG":"R12260","RHEA_ID":47055,"DIRECTION":"BI","MASTER_ID":47052,"compounds":"(2E,6E)-farnesyl diphosphate <=> alpha-selinene + diphosphate","pmd":177.943}
{"X":8220,"KEGG":"R12261","RHEA_ID":58171,"DIRECTION":"BI","MASTER_ID":58168,"compounds":"(2E,6E)-farnesyl diphosphate <=> (-)-5-epi-eremophilene + diphosphate","pmd":177.943}
{"X":8221,"KEGG":"R12287","RHEA_ID":58047,"DIRECTION":"BI","MASTER_ID":58044,"compounds":"a long-chain fatty acyl-CoA + alpha,alpha-trehalose <=> 2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + CoA","pmd":424.999}
{"X":8222,"KEGG":"R12288","RHEA_ID":38462,"DIRECTION":"BI","MASTER_ID":38459,"compounds":"2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + a mycolipenoyl-CoA <=> 2-O-(long-chain fatty acyl)-3-O-mycolipenoyl-trehalose + CoA"}
{"X":8223,"KEGG":"R12290","RHEA_ID":51507,"DIRECTION":"BI","MASTER_ID":51504,"compounds":"a 3'-hydro-2'-hydroxy-beta-oxodihydrochalcone + UDP-alpha-D-glucose <=> a 3'-(beta-D-glucopyranosyl)-2'-hydroxy-beta-oxodihydrochalcone + H(+) + UDP","pmd":162.053}
{"X":8224,"KEGG":"R12317","RHEA_ID":56755,"DIRECTION":"BI","MASTER_ID":56752,"compounds":"a 14alpha-methyl steroid + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> a Delta(14) steroid + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]","pmd":16.031}
{"X":8225,"KEGG":"R12353","RHEA_ID":59139,"DIRECTION":"BI","MASTER_ID":59136,"compounds":"ATP + citrate + D-ornithine <=> AMP + diphosphate + H(+) + N(5)-[(S)-citryl]-D-ornithine","pmd":114.079}
{"X":8226,"KEGG":"R12353","RHEA_ID":59139,"DIRECTION":"BI","MASTER_ID":59136,"compounds":"ATP + citrate + D-ornithine <=> AMP + diphosphate + H(+) + N(5)-[(S)-citryl]-D-ornithine","pmd":174.016}
{"X":8227,"KEGG":"R12353","RHEA_ID":59139,"DIRECTION":"BI","MASTER_ID":59136,"compounds":"ATP + citrate + D-ornithine <=> AMP + diphosphate + H(+) + N(5)-[(S)-citryl]-D-ornithine","pmd":159.933}
{"X":8228,"KEGG":"R12354","RHEA_ID":59143,"DIRECTION":"BI","MASTER_ID":59140,"compounds":"ATP + citrate + N(5)-[(S)-citryl]-D-ornithine <=> AMP + diphosphate + H(+) + staphyloferrin A","pmd":155.036}
{"X":8229,"KEGG":"R12354","RHEA_ID":59143,"DIRECTION":"BI","MASTER_ID":59140,"compounds":"ATP + citrate + N(5)-[(S)-citryl]-D-ornithine <=> AMP + diphosphate + H(+) + staphyloferrin A","pmd":26.873}
{"X":8230,"KEGG":"R12354","RHEA_ID":59143,"DIRECTION":"BI","MASTER_ID":59140,"compounds":"ATP + citrate + N(5)-[(S)-citryl]-D-ornithine <=> AMP + diphosphate + H(+) + staphyloferrin A","pmd":40.957}
{"X":8231,"KEGG":"R12357","RHEA_ID":60055,"DIRECTION":"BI","MASTER_ID":60052,"compounds":"a 3beta-hydroxy-4,4-dimethylsteroid + H(+) + NADH + O2 <=> a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H2O + NAD(+)","pmd":15.995}
{"X":8232,"KEGG":"R12357","RHEA_ID":60055,"DIRECTION":"BI","MASTER_ID":60052,"compounds":"a 3beta-hydroxy-4,4-dimethylsteroid + H(+) + NADH + O2 <=> a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H2O + NAD(+)","pmd":344.853}
{"X":8233,"KEGG":"R12358","RHEA_ID":60059,"DIRECTION":"BI","MASTER_ID":60056,"compounds":"a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H(+) + NADH + O2 <=> a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + 2 H2O + NAD(+)","pmd":2.016}
{"X":8234,"KEGG":"R12358","RHEA_ID":60059,"DIRECTION":"BI","MASTER_ID":60056,"compounds":"a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H(+) + NADH + O2 <=> a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + 2 H2O + NAD(+)","pmd":346.869}
{"X":8235,"KEGG":"R12359","RHEA_ID":60067,"DIRECTION":"BI","MASTER_ID":60064,"compounds":"a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + NADH + O2 <=> a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + H2O + NAD(+)","pmd":330.874}
{"X":8236,"KEGG":"R12359","RHEA_ID":60067,"DIRECTION":"BI","MASTER_ID":60064,"compounds":"a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + NADH + O2 <=> a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + H2O + NAD(+)","pmd":15.995}
{"X":8237,"KEGG":"R12360","RHEA_ID":60051,"DIRECTION":"BI","MASTER_ID":60048,"compounds":"a 3beta-hydroxy-4,4-dimethylsteroid + 2 H(+) + 3 NADH + 3 O2 <=> a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + 4 H2O + 3 NAD(+)","pmd":29.974}
{"X":8238,"KEGG":"R12360","RHEA_ID":60051,"DIRECTION":"BI","MASTER_ID":60048,"compounds":"a 3beta-hydroxy-4,4-dimethylsteroid + 2 H(+) + 3 NADH + 3 O2 <=> a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + 4 H2O + 3 NAD(+)","pmd":330.874}
{"X":8239,"KEGG":"R12361","RHEA_ID":60087,"DIRECTION":"BI","MASTER_ID":60084,"compounds":"a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NAD(+) <=> a 4alpha-methyl-3-oxosteroid + CO2 + NADH","pmd":46.006}
{"X":8240,"KEGG":"R12361","RHEA_ID":60087,"DIRECTION":"BI","MASTER_ID":60084,"compounds":"a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NAD(+) <=> a 4alpha-methyl-3-oxosteroid + CO2 + NADH","pmd":375.872}
{"X":8241,"KEGG":"R12362","RHEA_ID":60091,"DIRECTION":"BI","MASTER_ID":60088,"compounds":"a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NADP(+) <=> a 4alpha-methyl-3-oxosteroid + CO2 + NADPH","pmd":46.006}
{"X":8242,"KEGG":"R12362","RHEA_ID":60091,"DIRECTION":"BI","MASTER_ID":60088,"compounds":"a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NADP(+) <=> a 4alpha-methyl-3-oxosteroid + CO2 + NADPH","pmd":455.838}
{"X":8243,"KEGG":"R12380","RHEA_ID":58907,"DIRECTION":"BI","MASTER_ID":58904,"compounds":"8 (S)-methylmalonyl-CoA + 24 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 16 NADPH <=> C40-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+)","pmd":22.024}
{"X":8244,"KEGG":"R12380","RHEA_ID":58907,"DIRECTION":"BI","MASTER_ID":58904,"compounds":"8 (S)-methylmalonyl-CoA + 24 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 16 NADPH <=> C40-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+)","pmd":100.016}
{"X":8245,"KEGG":"R12381","RHEA_ID":58911,"DIRECTION":"BI","MASTER_ID":58908,"compounds":"7 (S)-methylmalonyl-CoA + 21 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 14 NADPH <=> C37-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 7 CO2 + 7 CoA + 7 H2O + 14 NADP(+)","pmd":100.016}
{"X":8246,"KEGG":"R12381","RHEA_ID":58911,"DIRECTION":"BI","MASTER_ID":58908,"compounds":"7 (S)-methylmalonyl-CoA + 21 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 14 NADPH <=> C37-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 7 CO2 + 7 CoA + 7 H2O + 14 NADP(+)","pmd":22.024}
{"X":8247,"KEGG":"R12393","RHEA_ID":59211,"DIRECTION":"BI","MASTER_ID":59208,"compounds":"ATP + H(+) + octadecanoate <=> diphosphate + octadecanoyl-AMP","pmd":329.053}
{"X":8248,"KEGG":"R12393","RHEA_ID":59211,"DIRECTION":"BI","MASTER_ID":59208,"compounds":"ATP + H(+) + octadecanoate <=> diphosphate + octadecanoyl-AMP","pmd":106.328}
{"X":8249,"KEGG":"R12394","RHEA_ID":59215,"DIRECTION":"BI","MASTER_ID":59212,"compounds":"holo-[(hydroxy)phthioceranic acid synthase] + octadecanoyl-AMP <=> AMP + H(+) + octadecanoyl-[(hydroxy)phthioceranic acid synthase]","pmd":266.261}
{"X":8250,"KEGG":"R12395","RHEA_ID":59171,"DIRECTION":"BI","MASTER_ID":59168,"compounds":"ATP + holo-[(hydroxy)phthioceranic acid synthase] + octadecanoate <=> AMP + diphosphate + octadecanoyl-[(hydroxy)phthioceranic acid synthase]","pmd":159.933}
{"X":8251,"KEGG":"R12395","RHEA_ID":59171,"DIRECTION":"BI","MASTER_ID":59168,"compounds":"ATP + holo-[(hydroxy)phthioceranic acid synthase] + octadecanoate <=> AMP + diphosphate + octadecanoyl-[(hydroxy)phthioceranic acid synthase]","pmd":62.792}
{"X":8252,"KEGG":"R12396","RHEA_ID":43711,"DIRECTION":"BI","MASTER_ID":43708,"compounds":"ATP + H(+) + hexadecanoate <=> diphosphate + hexadecanoyl-AMP","pmd":329.053}
{"X":8253,"KEGG":"R12396","RHEA_ID":43711,"DIRECTION":"BI","MASTER_ID":43708,"compounds":"ATP + H(+) + hexadecanoate <=> diphosphate + hexadecanoyl-AMP","pmd":78.297}
{"X":8254,"KEGG":"R12397","RHEA_ID":59175,"DIRECTION":"BI","MASTER_ID":59172,"compounds":"hexadecanoyl-AMP + holo-[(hydroxy)phthioceranic acid synthase] <=> AMP + H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase]","pmd":238.23}
{"X":8255,"KEGG":"R12398","RHEA_ID":59167,"DIRECTION":"BI","MASTER_ID":59164,"compounds":"ATP + hexadecanoate + holo-[(hydroxy)phthioceranic acid synthase] <=> AMP + diphosphate + hexadecanoyl-[(hydroxy)phthioceranic acid synthase]","pmd":90.823}
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{"X":13282,"KEGG":"R12405","pmd":2.016}
{"X":13283,"KEGG":"R12406","pmd":46.005}
{"X":13284,"KEGG":"R12406","pmd":469.854}
{"X":13285,"KEGG":"R12407","pmd":27.995}
{"X":13286,"KEGG":"R12407","pmd":28.079}
{"X":13287,"KEGG":"R12408","pmd":31.042}
{"X":13288,"KEGG":"R12409","pmd":35.977}
{"X":13289,"KEGG":"R12410","pmd":95.037}
{"X":13290,"KEGG":"R12410","pmd":129.043}
{"X":13291,"KEGG":"R12411","pmd":27.995}
{"X":13292,"KEGG":"R12411","pmd":15.995}
{"X":13293,"KEGG":"R12412","pmd":111.032}
{"X":13294,"KEGG":"R12413","pmd":168.069}
{"X":13295,"KEGG":"R12413","pmd":129.058}
{"X":13296,"KEGG":"R12414","pmd":14.016}
{"X":13297,"KEGG":"R12415","pmd":345.148}
{"X":13298,"KEGG":"R12417","pmd":148.853}
{"X":13299,"KEGG":"R12417","pmd":142.973}
{"X":13300,"KEGG":"R12417","pmd":210.015}
{"X":13301,"KEGG":"R12418","pmd":34.006}
{"X":13302,"KEGG":"R12419","pmd":45.085}
{"X":13303,"KEGG":"R12419","pmd":61.821}
{"X":13304,"KEGG":"R12420","pmd":2.016}
{"X":13305,"KEGG":"R12421","pmd":0}
{"X":13306,"KEGG":"R12423","pmd":147.035}
{"X":13307,"KEGG":"R12424","pmd":147.035}
{"X":13308,"KEGG":"R12429","pmd":159.933}
{"X":13309,"KEGG":"R12429","pmd":202.948}
{"X":13310,"KEGG":"R12430","pmd":126.105}
{"X":13311,"KEGG":"R12431","pmd":126.105}
{"X":13312,"KEGG":"R12433","pmd":159.933}
{"X":13313,"KEGG":"R12433","pmd":141.02}
{"X":13314,"KEGG":"R12434","pmd":30.116}
{"X":13315,"KEGG":"R12434","pmd":329.053}
{"X":13316,"KEGG":"R12435","pmd":190.049}
{"X":13317,"KEGG":"R12436","pmd":119.048}
{"X":13318,"KEGG":"R12436","pmd":168.069}
{"X":13319,"KEGG":"R12437","pmd":68.063}
{"X":13320,"KEGG":"R12437","pmd":145.195}
{"X":13321,"KEGG":"R12438","pmd":2.016}
{"X":13322,"KEGG":"R12439","pmd":68.063}
{"X":13323,"KEGG":"R12439","pmd":143.179}
{"X":13324,"KEGG":"R12440","pmd":2.016}
{"X":13325,"KEGG":"R12441","pmd":13.979}
{"X":13326,"KEGG":"R12442","pmd":15.995}
{"X":13327,"KEGG":"R12443","pmd":14.016}
{"X":13328,"KEGG":"R12444","pmd":15.995}
{"X":13329,"KEGG":"R12445","pmd":2.016}
{"X":13330,"KEGG":"R12446","pmd":15.995}
{"X":13331,"KEGG":"R12447","pmd":14.016}
{"X":13332,"KEGG":"R12448","pmd":15.995}
{"X":13333,"KEGG":"R12449","pmd":159.933}
{"X":13334,"KEGG":"R12449","pmd":141.02}
{"X":13335,"KEGG":"R12450","pmd":188.033}
{"X":13336,"KEGG":"R12454","pmd":46.005}
{"X":13337,"KEGG":"R12455","pmd":46.006}
{"X":13338,"KEGG":"R12458","pmd":14.016}
{"X":13339,"KEGG":"R12459","pmd":27.995}
{"X":13340,"KEGG":"R12461","pmd":27.995}
{"X":13341,"KEGG":"R12465","pmd":266.261}
{"X":13342,"KEGG":"R12466","pmd":238.23}
{"X":13343,"KEGG":"R12481","pmd":2.016}
{"X":13344,"KEGG":"R12483","pmd":2.016}
{"X":13345,"KEGG":"R12483","pmd":498.017}
{"X":13346,"KEGG":"R12484","pmd":498.017}
{"X":13347,"KEGG":"R12484","pmd":2.016}
{"X":13348,"KEGG":"R12485","pmd":159.933}
{"X":13349,"KEGG":"R12485","pmd":181.037}
{"X":13350,"KEGG":"R12485","pmd":148.016}
{"X":13351,"KEGG":"R12491","pmd":0}
{"X":13352,"KEGG":"R12492","pmd":18.011}
{"X":13353,"KEGG":"R12493","pmd":18.011}
{"X":13354,"KEGG":"R12493","pmd":18.01}
{"X":13355,"KEGG":"R12494","pmd":159.933}
{"X":13356,"KEGG":"R12495","pmd":159.933}
{"X":13357,"KEGG":"R12496","pmd":518.901}
{"X":13358,"KEGG":"R12497","pmd":14.016}
{"X":13359,"KEGG":"R12498","pmd":51.935}
{"X":13360,"KEGG":"R12498","pmd":305.041}
{"X":13361,"KEGG":"R12499","pmd":122.013}
{"X":13362,"KEGG":"R12501","pmd":27.995}
{"X":13363,"KEGG":"R12501","pmd":15.995}
{"X":13364,"KEGG":"R12502","pmd":516.08}
{"X":13365,"KEGG":"R12502","pmd":2.016}
{"X":13366,"KEGG":"R12503","pmd":500.085}
{"X":13367,"KEGG":"R12503","pmd":2.016}
{"X":13368,"KEGG":"R12505","pmd":17.993}
{"X":13369,"KEGG":"R12506","pmd":14.016}
{"X":13370,"KEGG":"R12507","pmd":1.032}
{"X":13371,"KEGG":"R12511","pmd":14.016}
{"X":13372,"KEGG":"R12511","pmd":536.046}
{"X":13373,"KEGG":"R12512","pmd":616.012}
{"X":13374,"KEGG":"R12512","pmd":14.016}
{"X":13375,"KEGG":"R12513","pmd":115.027}
{"X":13376,"KEGG":"R12517","pmd":497.01}
{"X":13377,"KEGG":"R12517","pmd":2.016}
{"X":13378,"KEGG":"R12518","pmd":576.976}
{"X":13379,"KEGG":"R12518","pmd":2.016}
{"X":13380,"KEGG":"R12522","pmd":2.016}
{"X":13381,"KEGG":"R12522","pmd":501.017}
{"X":13382,"KEGG":"R12523","pmd":485.059}
{"X":13383,"KEGG":"R12523","pmd":46.006}
{"X":13384,"KEGG":"R12524","pmd":1.99}
{"X":13385,"KEGG":"R12524","pmd":1.991}
{"X":13386,"KEGG":"R12525","pmd":162.053}
{"X":13387,"KEGG":"R12526","pmd":162.053}
{"X":13388,"KEGG":"R12528","pmd":162.053}
{"X":13389,"KEGG":"R12532","pmd":79.966}
{"X":13390,"KEGG":"R12533","pmd":79.966}
{"X":13391,"KEGG":"R12538","pmd":13.979}
{"X":13392,"KEGG":"R12538","pmd":18.011}
{"X":13393,"KEGG":"R12539","pmd":15.995}
{"X":13394,"KEGG":"R12539","pmd":209.02}
{"X":13395,"KEGG":"R12540","pmd":18.011}
{"X":13396,"KEGG":"R12540","pmd":10.994}
{"X":13397,"KEGG":"R12541","pmd":15.995}
{"X":13398,"KEGG":"R12541","pmd":18.011}
{"X":13399,"KEGG":"R12542","pmd":15.995}
{"X":13400,"KEGG":"R12542","pmd":18.011}
{"X":13401,"KEGG":"R12543","pmd":18.011}
{"X":13402,"KEGG":"R12543","pmd":10.994}
{"X":13403,"KEGG":"R12544","pmd":209.02}
{"X":13404,"KEGG":"R12544","pmd":18.011}
{"X":13405,"KEGG":"R12544","pmd":2.016}
{"X":13406,"KEGG":"R12545","pmd":13.979}
{"X":13407,"KEGG":"R12545","pmd":18.011}
{"X":13408,"KEGG":"R12546","pmd":18.011}
{"X":13409,"KEGG":"R12546","pmd":2.016}
{"X":13410,"KEGG":"R12546","pmd":209.02}
{"X":13411,"KEGG":"R12547","pmd":13.979}
{"X":13412,"KEGG":"R12547","pmd":18.011}
{"X":13413,"KEGG":"R12548","pmd":219.954}
{"X":13414,"KEGG":"R12548","pmd":12}
{"X":13415,"KEGG":"R12549","pmd":42.011}
{"X":13416,"KEGG":"R12560","pmd":501.017}
{"X":13417,"KEGG":"R12560","pmd":2.016}
{"X":13418,"KEGG":"R12566","pmd":134.037}
{"X":13419,"KEGG":"R12569","pmd":147.035}
{"X":13420,"KEGG":"R12572","pmd":329.053}
{"X":13421,"KEGG":"R12572","pmd":3.832}
{"X":13422,"KEGG":"R12573","pmd":172.951}
{"X":13423,"KEGG":"R12573","pmd":159.933}
{"X":13424,"KEGG":"R12574","pmd":156.101}
{"X":13425,"KEGG":"R12575","pmd":232}
{"X":13426,"KEGG":"R12575","pmd":159.933}
{"X":13427,"KEGG":"R12576","pmd":329.053}
{"X":13428,"KEGG":"R12576","pmd":23.917}
{"X":13429,"KEGG":"R12577","pmd":136.016}
{"X":13430,"KEGG":"R12578","pmd":305.068}
{"X":13431,"KEGG":"R12580","pmd":143.956}
{"X":13432,"KEGG":"R12587","pmd":79.966}
{"X":13433,"KEGG":"R12588","pmd":117.025}
{"X":13434,"KEGG":"R12589","pmd":79.966}
{"X":13435,"KEGG":"R12591","pmd":15.995}
{"X":13436,"KEGG":"R12592","pmd":15.995}
{"X":13437,"KEGG":"R12593","pmd":18.011}
{"X":13438,"KEGG":"R12594","pmd":79.966}
{"X":13439,"KEGG":"R12595","pmd":79.966}
{"X":13440,"KEGG":"R12596","pmd":159.933}
{"X":13441,"KEGG":"R12596","pmd":127.147}
{"X":13442,"KEGG":"R12596","pmd":174.016}
{"X":13443,"KEGG":"R12597","pmd":136.016}
{"X":13444,"KEGG":"R12598","pmd":201.905}
{"X":13445,"KEGG":"R12598","pmd":27.889}
{"X":13446,"KEGG":"R12598","pmd":60.674}
{"X":13447,"KEGG":"R12599","pmd":201.905}
{"X":13448,"KEGG":"R12599","pmd":75.342}
{"X":13449,"KEGG":"R12599","pmd":108.127}
{"X":13450,"KEGG":"R12600","pmd":136.016}
{"X":13451,"KEGG":"R12601","pmd":136.016}
{"X":13452,"KEGG":"R12605","pmd":6.047}
{"X":13453,"RHEA_ID":10000,"DIRECTION":"UN","MASTER_ID":10000,"ec":"3.5.1.50","metacyc":"PENTANAMIDASE-RXN","compounds":"H2O + pentanamide = NH4(+) + pentanoate"}
{"X":13454,"RHEA_ID":10001,"compounds":"H2O + pentanamide => NH4(+) + pentanoate"}
{"X":13455,"RHEA_ID":10002,"compounds":"NH4(+) + pentanoate => H2O + pentanamide"}
{"X":13456,"RHEA_ID":19837,"DIRECTION":"UN","MASTER_ID":19837,"ec":"1.1.1.140","compounds":"D-sorbitol 6-phosphate + NAD(+) = beta-D-fructose 6-phosphate + H(+) + NADH"}
{"X":13457,"RHEA_ID":10004,"DIRECTION":"UN","MASTER_ID":10004,"ec":"5.99.1.1","metacyc":"THIOCYANATE-ISOMERASE-RXN","compounds":"benzyl isothiocyanate = benzyl thiocyanate"}
{"X":13458,"RHEA_ID":10005,"compounds":"benzyl isothiocyanate => benzyl thiocyanate"}
{"X":13459,"RHEA_ID":10006,"compounds":"benzyl thiocyanate => benzyl isothiocyanate"}
{"X":13460,"RHEA_ID":19841,"DIRECTION":"UN","MASTER_ID":19841,"ec":"1.2.7.12","compounds":"H2O + N-formylmethanofuran + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2 + H(+) + methanofuran + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":13461,"RHEA_ID":10008,"DIRECTION":"UN","MASTER_ID":10008,"ec":"1.11.1.15","compounds":"[protein]-dithiol + a hydroperoxide = [protein]-disulfide + an alcohol + H2O"}
{"X":13462,"RHEA_ID":10009,"compounds":"[protein]-dithiol + a hydroperoxide => [protein]-disulfide + an alcohol + H2O"}
{"X":13463,"RHEA_ID":10010,"compounds":"[protein]-disulfide + an alcohol + H2O => [protein]-dithiol + a hydroperoxide"}
{"X":13464,"RHEA_ID":10012,"DIRECTION":"UN","MASTER_ID":10012,"ec":"1.5.3.6","compounds":"(R)-6-hydroxynicotine + H2O + O2 = 6-hydroxypseudooxynicotine + H2O2"}
{"X":13465,"RHEA_ID":10013,"DIRECTION":"LR","MASTER_ID":10012,"metacyc":"R-6-HYDROXYNICOTINE-OXIDASE-RXN","compounds":"(R)-6-hydroxynicotine + H2O + O2 => 6-hydroxypseudooxynicotine + H2O2"}
{"X":13466,"RHEA_ID":10014,"compounds":"6-hydroxypseudooxynicotine + H2O2 => (R)-6-hydroxynicotine + H2O + O2"}
{"X":13467,"RHEA_ID":19849,"compounds":"H2O + NADP(+) = ADP-D-ribose 2'-phosphate + H(+) + nicotinamide"}
{"X":13468,"RHEA_ID":10016,"DIRECTION":"UN","MASTER_ID":10016,"ec":"3.1.1.49","compounds":"H2O + O-sinapoylcholine = choline + H(+) + trans-sinapate"}
{"X":13469,"RHEA_ID":10017,"DIRECTION":"LR","MASTER_ID":10016,"metacyc":"SINAPINE-ESTERASE-RXN","compounds":"H2O + O-sinapoylcholine => choline + H(+) + trans-sinapate"}
{"X":13470,"RHEA_ID":10018,"compounds":"choline + H(+) + trans-sinapate => H2O + O-sinapoylcholine"}
{"X":13471,"RHEA_ID":19857,"DIRECTION":"UN","MASTER_ID":19857,"ec":"1.1.1.147","metacyc":"1.1.1.147-RXN","compounds":"a 16alpha-hydroxysteroid + NADP(+) = a 16-oxosteroid + H(+) + NADPH"}
{"X":13472,"RHEA_ID":10020,"DIRECTION":"UN","MASTER_ID":10020,"ec":"1.5.1.10","compounds":"H2O + L-saccharopine + NADP(+) = (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADPH"}
{"X":13473,"RHEA_ID":10021,"compounds":"H2O + L-saccharopine + NADP(+) => (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADPH"}
{"X":13474,"RHEA_ID":10022,"DIRECTION":"RL","MASTER_ID":10020,"metacyc":"RXN3O-127","compounds":"(S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADPH => H2O + L-saccharopine + NADP(+)"}
{"X":13475,"RHEA_ID":19861,"DIRECTION":"UN","MASTER_ID":19861,"ec":"1.1.1.147","metacyc":"1.1.1.147-RXN","compounds":"a 16alpha-hydroxysteroid + NAD(+) = a 16-oxosteroid + H(+) + NADH"}
{"X":13476,"RHEA_ID":10024,"compounds":"L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine"}
{"X":13477,"RHEA_ID":10025,"DIRECTION":"LR","MASTER_ID":10024,"metacyc":"HISTONE-LYSINE-N-METHYLTRANSFERASE-RXN","compounds":"L-lysyl-[histone] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine"}
{"X":13478,"RHEA_ID":10026,"compounds":"H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine => L-lysyl-[histone] + S-adenosyl-L-methionine"}
{"X":13479,"RHEA_ID":19865,"DIRECTION":"UN","MASTER_ID":19865,"ec":"4.1.1.37","compounds":"4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen III"}
{"X":13480,"RHEA_ID":10028,"DIRECTION":"UN","MASTER_ID":10028,"ec":"1.4.3.7","compounds":"D-glutamate + H2O + O2 = 2-oxoglutarate + H2O2 + NH4(+)"}
{"X":13481,"RHEA_ID":10028,"DIRECTION":"UN","MASTER_ID":10028,"ec":"1.4.3.15","compounds":"D-glutamate + H2O + O2 = 2-oxoglutarate + H2O2 + NH4(+)"}
{"X":13482,"RHEA_ID":10029,"DIRECTION":"LR","MASTER_ID":10028,"metacyc":"D-GLUTAMATE-OXIDASE-RXN","compounds":"D-glutamate + H2O + O2 => 2-oxoglutarate + H2O2 + NH4(+)"}
{"X":13483,"RHEA_ID":10030,"compounds":"2-oxoglutarate + H2O2 + NH4(+) => D-glutamate + H2O + O2"}
{"X":13484,"RHEA_ID":19870,"compounds":"an acyl-CoA + glycine => an N-acylglycine + CoA + H(+)"}
{"X":13485,"RHEA_ID":10032,"DIRECTION":"UN","MASTER_ID":10032,"ec":"3.5.1.43","metacyc":"PEPTIDYL-GLUTAMINASE-RXN","compounds":"[protein]-C-terminal-L-glutamine + H2O = [protein]-C-terminal-L-glutamate + NH4(+)"}
{"X":13486,"RHEA_ID":10033,"compounds":"[protein]-C-terminal-L-glutamine + H2O => [protein]-C-terminal-L-glutamate + NH4(+)"}
{"X":13487,"RHEA_ID":10034,"compounds":"[protein]-C-terminal-L-glutamate + NH4(+) => [protein]-C-terminal-L-glutamine + H2O"}
{"X":13488,"RHEA_ID":10036,"DIRECTION":"UN","MASTER_ID":10036,"ec":"1.1.3.38","compounds":"4-hydroxy-3-methoxy-benzenemethanol + O2 = H2O2 + vanillin"}
{"X":13489,"RHEA_ID":10037,"DIRECTION":"LR","MASTER_ID":10036,"metacyc":"1.1.3.38-RXN","compounds":"4-hydroxy-3-methoxy-benzenemethanol + O2 => H2O2 + vanillin"}
{"X":13490,"RHEA_ID":10038,"compounds":"H2O2 + vanillin => 4-hydroxy-3-methoxy-benzenemethanol + O2"}
{"X":13491,"RHEA_ID":19878,"DIRECTION":"LR","MASTER_ID":19877,"metacyc":"1-PHOSPHATIDYLINOSITOL-KINASE-RXN","compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP => 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)"}
{"X":13492,"RHEA_ID":10040,"DIRECTION":"UN","MASTER_ID":10040,"ec":"3.1.3.7","compounds":"adenosine 3',5'-bisphosphate + H2O = AMP + phosphate"}
{"X":13493,"RHEA_ID":10041,"DIRECTION":"LR","MASTER_ID":10040,"ecocyc":"325-BISPHOSPHATE-NUCLEOTIDASE-RXN","metacyc":"325-BISPHOSPHATE-NUCLEOTIDASE-RXN","reactome":"R-HSA-8953499.2","compounds":"adenosine 3',5'-bisphosphate + H2O => AMP + phosphate"}
{"X":13494,"RHEA_ID":10041,"DIRECTION":"LR","MASTER_ID":10040,"ecocyc":"325-BISPHOSPHATE-NUCLEOTIDASE-RXN","metacyc":"325-BISPHOSPHATE-NUCLEOTIDASE-RXN","reactome":"R-HSA-176606.2","compounds":"adenosine 3',5'-bisphosphate + H2O => AMP + phosphate"}
{"X":13495,"RHEA_ID":10042,"compounds":"AMP + phosphate => adenosine 3',5'-bisphosphate + H2O"}
{"X":13496,"RHEA_ID":19883,"compounds":"diphosphate + H(+) + N(epsilon)-GMP-L-lysyl-[protein] => GTP + L-lysyl-[protein]"}
{"X":13497,"RHEA_ID":10044,"DIRECTION":"UN","MASTER_ID":10044,"ec":"1.1.1.245","compounds":"cyclohexanol + NAD(+) = cyclohexanone + H(+) + NADH"}
{"X":13498,"RHEA_ID":10045,"DIRECTION":"LR","MASTER_ID":10044,"metacyc":"CYCLOHEXANOL-DEHYDROGENASE-RXN","compounds":"cyclohexanol + NAD(+) => cyclohexanone + H(+) + NADH"}
{"X":13499,"RHEA_ID":10046,"compounds":"cyclohexanone + H(+) + NADH => cyclohexanol + NAD(+)"}
{"X":13500,"RHEA_ID":19887,"compounds":"(S)-scoulerine + H(+) + H2O2 => (S)-reticuline + O2"}
{"X":13501,"RHEA_ID":10048,"DIRECTION":"UN","MASTER_ID":10048,"ec":"2.5.1.49","compounds":"methanethiol + O-acetyl-L-homoserine = acetate + H(+) + L-methionine"}
{"X":13502,"RHEA_ID":10049,"DIRECTION":"LR","MASTER_ID":10048,"metacyc":"O-ACETYLHOMOSERINE-THIOL-LYASE-RXN","compounds":"methanethiol + O-acetyl-L-homoserine => acetate + H(+) + L-methionine"}
{"X":13503,"RHEA_ID":10050,"compounds":"acetate + H(+) + L-methionine => methanethiol + O-acetyl-L-homoserine"}
{"X":13504,"RHEA_ID":19891,"compounds":"diphosphate + UDP-alpha-D-glucose => alpha-D-glucose 1-phosphate + H(+) + UTP"}
{"X":13505,"RHEA_ID":10052,"DIRECTION":"UN","MASTER_ID":10052,"ec":"1.1.1.345","compounds":"(R)-2-hydroxy-4-methylpentanoate + NAD(+) = 4-methyl-2-oxopentanoate + H(+) + NADH"}
{"X":13506,"RHEA_ID":10053,"compounds":"(R)-2-hydroxy-4-methylpentanoate + NAD(+) => 4-methyl-2-oxopentanoate + H(+) + NADH"}
{"X":13507,"RHEA_ID":10054,"DIRECTION":"RL","MASTER_ID":10052,"metacyc":"RXN-16245","compounds":"4-methyl-2-oxopentanoate + H(+) + NADH => (R)-2-hydroxy-4-methylpentanoate + NAD(+)"}
{"X":13508,"RHEA_ID":10055,"compounds":"(R)-2-hydroxy-4-methylpentanoate + NAD(+) <=> 4-methyl-2-oxopentanoate + H(+) + NADH"}
{"X":13509,"RHEA_ID":10056,"DIRECTION":"UN","MASTER_ID":10056,"ec":"4.3.1.14","compounds":"(3S)-3-aminobutanoyl-CoA = (2E)-butenoyl-CoA + NH4(+)"}
{"X":13510,"RHEA_ID":10057,"compounds":"(3S)-3-aminobutanoyl-CoA => (2E)-butenoyl-CoA + NH4(+)"}
{"X":13511,"RHEA_ID":10058,"compounds":"(2E)-butenoyl-CoA + NH4(+) => (3S)-3-aminobutanoyl-CoA"}
{"X":13512,"RHEA_ID":19898,"DIRECTION":"LR","MASTER_ID":19897,"metacyc":"RXN-13568","compounds":"H(+) + 2 L-arginine + 3 NADPH + 4 O2 => 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide"}
{"X":13513,"RHEA_ID":10060,"DIRECTION":"UN","MASTER_ID":10060,"ec":"2.3.1.34","metacyc":"D-TRYPTOPHAN-N-ACETYLTRANSFERASE-RXN","compounds":"acetyl-CoA + D-tryptophan = CoA + H(+) + N-acetyl-D-tryptophan"}
{"X":13514,"RHEA_ID":10061,"compounds":"acetyl-CoA + D-tryptophan => CoA + H(+) + N-acetyl-D-tryptophan"}
{"X":13515,"RHEA_ID":10062,"compounds":"CoA + H(+) + N-acetyl-D-tryptophan => acetyl-CoA + D-tryptophan"}
{"X":13516,"RHEA_ID":19902,"compounds":"L-tryptophan + O2 => alpha,beta-didehydrotryptophan + H2O2"}
{"X":13517,"RHEA_ID":10064,"DIRECTION":"UN","MASTER_ID":10064,"ec":"2.1.2.7","metacyc":"D-ALANINE-HYDROXYMETHYLTRANSFERASE-RXN","compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + D-alanine + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-methylserine"}
{"X":13518,"RHEA_ID":10065,"compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + D-alanine + H2O => (6S)-5,6,7,8-tetrahydrofolate + 2-methylserine"}
{"X":13519,"RHEA_ID":10066,"compounds":"(6S)-5,6,7,8-tetrahydrofolate + 2-methylserine => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + D-alanine + H2O"}
{"X":13520,"RHEA_ID":19906,"DIRECTION":"LR","MASTER_ID":19905,"metacyc":"RXN-13414","compounds":"NAD(+) + spermidine => dehydrospermidine + H(+) + NADH"}
{"X":13521,"RHEA_ID":10068,"DIRECTION":"UN","MASTER_ID":10068,"ec":"2.4.1.53","compounds":"4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-alpha-D-glucose = 4-O-[(2-beta-D-glucosyl-D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP"}
{"X":13522,"RHEA_ID":10069,"DIRECTION":"LR","MASTER_ID":10068,"metacyc":"RXN-18017","compounds":"4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-alpha-D-glucose => 4-O-[(2-beta-D-glucosyl-D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP"}
{"X":13523,"RHEA_ID":10070,"compounds":"4-O-[(2-beta-D-glucosyl-D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP => 4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-alpha-D-glucose"}
{"X":13524,"RHEA_ID":19910,"DIRECTION":"LR","MASTER_ID":19909,"metacyc":"L-LACTATE-DEHYDROGENASE-CYTOCHROME-RXN","compounds":"(S)-lactate + 2 [Fe(III)cytochrome c] => 2 [Fe(II)cytochrome c] + 2 H(+) + pyruvate"}
{"X":13525,"RHEA_ID":10072,"DIRECTION":"UN","MASTER_ID":10072,"ec":"2.1.1.161","compounds":"N,N-dimethylglycine + S-adenosyl-L-methionine = betaine + H(+) + S-adenosyl-L-homocysteine"}
{"X":13526,"RHEA_ID":10073,"DIRECTION":"LR","MASTER_ID":10072,"metacyc":"RXN-9680","compounds":"N,N-dimethylglycine + S-adenosyl-L-methionine => betaine + H(+) + S-adenosyl-L-homocysteine"}
{"X":13527,"RHEA_ID":10074,"compounds":"betaine + H(+) + S-adenosyl-L-homocysteine => N,N-dimethylglycine + S-adenosyl-L-methionine"}
{"X":13528,"RHEA_ID":19914,"compounds":"a (3R)-hydroxyacyl-[ACP] + NAD(+) => a 3-oxoacyl-[ACP] + H(+) + NADH"}
{"X":13529,"RHEA_ID":10076,"DIRECTION":"UN","MASTER_ID":10076,"ec":"3.2.1.108","compounds":"H2O + lactose = D-galactose + D-glucose"}
{"X":13530,"RHEA_ID":10077,"DIRECTION":"LR","MASTER_ID":10076,"metacyc":"LACTASE-RXN","compounds":"H2O + lactose => D-galactose + D-glucose"}
{"X":13531,"RHEA_ID":10078,"compounds":"D-galactose + D-glucose => H2O + lactose"}
{"X":13532,"RHEA_ID":19921,"DIRECTION":"UN","MASTER_ID":19921,"ec":"1.1.1.405","compounds":"D-ribitol 5-phosphate + NADP(+) = D-ribulose 5-phosphate + H(+) + NADPH"}
{"X":13533,"RHEA_ID":10080,"DIRECTION":"UN","MASTER_ID":10080,"ec":"1.3.1.57","compounds":"dihydrophloroglucinol + NADP(+) = 1,3,5-trihydroxybenzene + NADPH"}
{"X":13534,"RHEA_ID":10081,"compounds":"dihydrophloroglucinol + NADP(+) => 1,3,5-trihydroxybenzene + NADPH"}
{"X":13535,"RHEA_ID":10082,"compounds":"1,3,5-trihydroxybenzene + NADPH => dihydrophloroglucinol + NADP(+)"}
{"X":13536,"RHEA_ID":30480,"DIRECTION":"LR","MASTER_ID":30479,"metacyc":"RXN-9636","compounds":"L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase]"}
{"X":13537,"RHEA_ID":10084,"DIRECTION":"UN","MASTER_ID":10084,"ec":"1.13.11.3","compounds":"3,4-dihydroxybenzoate + O2 = 3-carboxy-cis,cis-muconate + 2 H(+)"}
{"X":13538,"RHEA_ID":10085,"DIRECTION":"LR","MASTER_ID":10084,"metacyc":"PROTOCATECHUATE-34-DIOXYGENASE-RXN","compounds":"3,4-dihydroxybenzoate + O2 => 3-carboxy-cis,cis-muconate + 2 H(+)"}
{"X":13539,"RHEA_ID":10086,"compounds":"3-carboxy-cis,cis-muconate + 2 H(+) => 3,4-dihydroxybenzoate + O2"}
{"X":13540,"RHEA_ID":30484,"DIRECTION":"LR","MASTER_ID":30483,"metacyc":"RXN-9638","compounds":"N-hydroxy-L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase]"}
{"X":13541,"RHEA_ID":10088,"DIRECTION":"UN","MASTER_ID":10088,"ec":"2.4.1.167","compounds":"sucrose + UDP-alpha-D-galactose = 6(F)-alpha-D-galactosylsucrose + H(+) + UDP"}
{"X":13542,"RHEA_ID":10089,"compounds":"sucrose + UDP-alpha-D-galactose => 6(F)-alpha-D-galactosylsucrose + H(+) + UDP"}
{"X":13543,"RHEA_ID":10090,"compounds":"6(F)-alpha-D-galactosylsucrose + H(+) + UDP => sucrose + UDP-alpha-D-galactose"}
{"X":13544,"RHEA_ID":30488,"DIRECTION":"LR","MASTER_ID":30487,"metacyc":"RXN-9639","compounds":"H(+) + N,N-dihydroxy-L-isoleucine => (1E,2S)-2-methylbutanal oxime + CO2 + H2O"}
{"X":13545,"RHEA_ID":10092,"DIRECTION":"UN","MASTER_ID":10092,"ec":"3.1.3.34","compounds":"a 2'-deoxyribonucleoside 3'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate"}
{"X":13546,"RHEA_ID":10093,"DIRECTION":"LR","MASTER_ID":10092,"ecocyc":"DEOXYNUCLEOTIDE-3-PHOSPHATASE-RXN","metacyc":"DEOXYNUCLEOTIDE-3-PHOSPHATASE-RXN","compounds":"a 2'-deoxyribonucleoside 3'-phosphate + H2O => a 2'-deoxyribonucleoside + phosphate"}
{"X":13547,"RHEA_ID":10094,"compounds":"a 2'-deoxyribonucleoside + phosphate => a 2'-deoxyribonucleoside 3'-phosphate + H2O"}
{"X":13548,"RHEA_ID":10096,"DIRECTION":"UN","MASTER_ID":10096,"ec":"2.3.1.184","compounds":"a fatty acyl-[ACP] + S-adenosyl-L-methionine = an N-acyl-L-homoserine lactone + H(+) + holo-[ACP] + S-methyl-5'-thioadenosine"}
{"X":13549,"RHEA_ID":10097,"DIRECTION":"LR","MASTER_ID":10096,"metacyc":"2.3.1.184-RXN","compounds":"a fatty acyl-[ACP] + S-adenosyl-L-methionine => an N-acyl-L-homoserine lactone + H(+) + holo-[ACP] + S-methyl-5'-thioadenosine"}
{"X":13550,"RHEA_ID":10098,"compounds":"an N-acyl-L-homoserine lactone + H(+) + holo-[ACP] + S-methyl-5'-thioadenosine => a fatty acyl-[ACP] + S-adenosyl-L-methionine"}
{"X":13551,"RHEA_ID":30496,"DIRECTION":"LR","MASTER_ID":30495,"metacyc":"RXN-5064","compounds":"N-hydroxy-L-valine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-valine + oxidized [NADPH--hemoprotein reductase]"}
{"X":13552,"RHEA_ID":10100,"DIRECTION":"UN","MASTER_ID":10100,"ec":"3.1.1.13","compounds":"a sterol ester + H2O = a fatty acid + a sterol + H(+)"}
{"X":13553,"RHEA_ID":10101,"DIRECTION":"LR","MASTER_ID":10100,"metacyc":"STEROL-ESTERASE-RXN","compounds":"a sterol ester + H2O => a fatty acid + a sterol + H(+)"}
{"X":13554,"RHEA_ID":10102,"compounds":"a fatty acid + a sterol + H(+) => a sterol ester + H2O"}
{"X":13555,"RHEA_ID":10104,"DIRECTION":"UN","MASTER_ID":10104,"ec":"1.14.11.15","compounds":"2-oxoglutarate + gibberellin A20 + O2 = CO2 + gibberellin A1 + succinate"}
{"X":13556,"RHEA_ID":10105,"DIRECTION":"LR","MASTER_ID":10104,"metacyc":"RXN1F-170","compounds":"2-oxoglutarate + gibberellin A20 + O2 => CO2 + gibberellin A1 + succinate"}
{"X":13557,"RHEA_ID":10106,"compounds":"CO2 + gibberellin A1 + succinate => 2-oxoglutarate + gibberellin A20 + O2"}
{"X":13558,"RHEA_ID":10108,"DIRECTION":"UN","MASTER_ID":10108,"ec":"1.1.1.248","compounds":"(7S)-salutaridinol + NADP(+) = H(+) + NADPH + salutaridine"}
{"X":13559,"RHEA_ID":10109,"compounds":"(7S)-salutaridinol + NADP(+) => H(+) + NADPH + salutaridine"}
{"X":13560,"RHEA_ID":10110,"compounds":"H(+) + NADPH + salutaridine => (7S)-salutaridinol + NADP(+)"}
{"X":13561,"RHEA_ID":30508,"compounds":"2-demethylmenaquinone-8 + H(+) + NADH => 2-demethylmenaquinol-8 + NAD(+)"}
{"X":13562,"RHEA_ID":10112,"DIRECTION":"UN","MASTER_ID":10112,"ec":"4.2.1.22","compounds":"L-homocysteine + L-serine = H2O + L,L-cystathionine"}
{"X":13563,"RHEA_ID":10113,"compounds":"L-homocysteine + L-serine => H2O + L,L-cystathionine"}
{"X":13564,"RHEA_ID":10114,"compounds":"H2O + L,L-cystathionine => L-homocysteine + L-serine"}
{"X":13565,"RHEA_ID":10116,"DIRECTION":"UN","MASTER_ID":10116,"ec":"1.1.1.44","compounds":"6-phospho-D-gluconate + NADP(+) = CO2 + D-ribulose 5-phosphate + NADPH"}
{"X":13566,"RHEA_ID":10116,"DIRECTION":"UN","MASTER_ID":10116,"ec":"1.1.1.351","compounds":"6-phospho-D-gluconate + NADP(+) = CO2 + D-ribulose 5-phosphate + NADPH"}
{"X":13567,"RHEA_ID":10117,"DIRECTION":"LR","MASTER_ID":10116,"ecocyc":"RXN-9952","metacyc":"6PGLUCONDEHYDROG-RXN","reactome":"R-HSA-71299.3","compounds":"6-phospho-D-gluconate + NADP(+) => CO2 + D-ribulose 5-phosphate + NADPH"}
{"X":13568,"RHEA_ID":10117,"DIRECTION":"LR","MASTER_ID":10116,"ecocyc":"RXN-9952","metacyc":"RXN-9952","reactome":"R-HSA-71299.3","compounds":"6-phospho-D-gluconate + NADP(+) => CO2 + D-ribulose 5-phosphate + NADPH"}
{"X":13569,"RHEA_ID":10118,"compounds":"CO2 + D-ribulose 5-phosphate + NADPH => 6-phospho-D-gluconate + NADP(+)"}
{"X":13570,"RHEA_ID":19962,"DIRECTION":"LR","MASTER_ID":19961,"metacyc":"NUCLEOSIDE-PHOSPHOTRANSFERASE-RXN","compounds":"a 2'-deoxyribonucleoside + a ribonucleoside 5'-phosphate => a 2'-deoxyribonucleoside 5'-phosphate + a ribonucleoside"}
{"X":13571,"RHEA_ID":10120,"DIRECTION":"UN","MASTER_ID":10120,"ec":"3.5.4.37","compounds":"adenosine in double-stranded RNA + H(+) + H2O = inosine in double-stranded RNA + NH4(+)"}
{"X":13572,"RHEA_ID":10121,"DIRECTION":"LR","MASTER_ID":10120,"ecocyc":"AMINOCYL-TRNA-HYDROLASE-RXN","metacyc":"AMINOCYL-TRNA-HYDROLASE-RXN","compounds":"adenosine in double-stranded RNA + H(+) + H2O => inosine in double-stranded RNA + NH4(+)"}
{"X":13573,"RHEA_ID":10122,"compounds":"inosine in double-stranded RNA + NH4(+) => adenosine in double-stranded RNA + H(+) + H2O"}
{"X":13574,"RHEA_ID":10123,"DIRECTION":"BI","MASTER_ID":10120,"metacyc":"RXN-13992","compounds":"adenosine in double-stranded RNA + H(+) + H2O <=> inosine in double-stranded RNA + NH4(+)"}
{"X":13575,"RHEA_ID":10124,"DIRECTION":"UN","MASTER_ID":10124,"ec":"1.14.13.92","compounds":"H(+) + NADPH + O2 + phenylacetone = benzyl acetate + H2O + NADP(+)"}
{"X":13576,"RHEA_ID":10125,"DIRECTION":"LR","MASTER_ID":10124,"metacyc":"1.14.13.92-RXN","compounds":"H(+) + NADPH + O2 + phenylacetone => benzyl acetate + H2O + NADP(+)"}
{"X":13577,"RHEA_ID":10126,"compounds":"benzyl acetate + H2O + NADP(+) => H(+) + NADPH + O2 + phenylacetone"}
{"X":13578,"RHEA_ID":19970,"DIRECTION":"LR","MASTER_ID":19969,"metacyc":"RXN-13595","compounds":"hydroxylamine + O2 => H(+) + H2O + nitrite"}
{"X":13579,"RHEA_ID":10128,"DIRECTION":"UN","MASTER_ID":10128,"ec":"5.3.99.9","compounds":"all-trans-violaxanthin = all-trans-neoxanthin"}
{"X":13580,"RHEA_ID":10129,"DIRECTION":"LR","MASTER_ID":10128,"metacyc":"RXN1F-155","compounds":"all-trans-violaxanthin => all-trans-neoxanthin"}
{"X":13581,"RHEA_ID":10130,"compounds":"all-trans-neoxanthin => all-trans-violaxanthin"}
{"X":13582,"RHEA_ID":19973,"DIRECTION":"UN","MASTER_ID":19973,"ec":"2.5.1.22","compounds":"S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = H(+) + S-methyl-5'-thioadenosine + spermine"}
{"X":13583,"RHEA_ID":10132,"DIRECTION":"UN","MASTER_ID":10132,"ec":"6.2.1.25","compounds":"ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate"}
{"X":13584,"RHEA_ID":10133,"DIRECTION":"LR","MASTER_ID":10132,"metacyc":"BENZOATE--COA-LIGASE-RXN","reactome":"R-HSA-159443.2","compounds":"ATP + benzoate + CoA => AMP + benzoyl-CoA + diphosphate"}
{"X":13585,"RHEA_ID":10134,"compounds":"AMP + benzoyl-CoA + diphosphate => ATP + benzoate + CoA"}
{"X":13586,"RHEA_ID":19977,"DIRECTION":"UN","MASTER_ID":19977,"ec":"2.8.2.9","metacyc":"TYROSINE-ESTER-SULFOTRANSFERASE-RXN","compounds":"3'-phosphoadenylyl sulfate + L-tyrosine methyl ester = adenosine 3',5'-bisphosphate + H(+) + L-tyrosine methyl ester 4-sulfate"}
{"X":13587,"RHEA_ID":10136,"DIRECTION":"UN","MASTER_ID":10136,"ec":"4.1.1.47","compounds":"2 glyoxylate + H(+) = 2-hydroxy-3-oxopropanoate + CO2"}
{"X":13588,"RHEA_ID":10137,"DIRECTION":"LR","MASTER_ID":10136,"ecocyc":"GLYOCARBOLIG-RXN","macie":"M0298","metacyc":"GLYOCARBOLIG-RXN","compounds":"2 glyoxylate + H(+) => 2-hydroxy-3-oxopropanoate + CO2"}
{"X":13589,"RHEA_ID":10138,"compounds":"2-hydroxy-3-oxopropanoate + CO2 => 2 glyoxylate + H(+)"}
{"X":13590,"RHEA_ID":10140,"DIRECTION":"UN","MASTER_ID":10140,"ec":"1.1.1.188","compounds":"NADP(+) + prostaglandin F2alpha = H(+) + NADPH + prostaglandin D2"}
{"X":13591,"RHEA_ID":10141,"compounds":"NADP(+) + prostaglandin F2alpha => H(+) + NADPH + prostaglandin D2"}
{"X":13592,"RHEA_ID":10142,"compounds":"H(+) + NADPH + prostaglandin D2 => NADP(+) + prostaglandin F2alpha"}
{"X":13593,"RHEA_ID":19985,"DIRECTION":"UN","MASTER_ID":19985,"ec":"1.1.1.284","compounds":"NAD(+) + S-(hydroxymethyl)glutathione = H(+) + NADH + S-formylglutathione"}
{"X":13594,"RHEA_ID":10144,"DIRECTION":"UN","MASTER_ID":10144,"ec":"3.1.3.6","compounds":"a ribonucleoside 3'-phosphate + H2O = a ribonucleoside + phosphate"}
{"X":13595,"RHEA_ID":10145,"DIRECTION":"LR","MASTER_ID":10144,"ecocyc":"3-NUCLEOTID-RXN","metacyc":"3-NUCLEOTID-RXN","compounds":"a ribonucleoside 3'-phosphate + H2O => a ribonucleoside + phosphate"}
{"X":13596,"RHEA_ID":10146,"compounds":"a ribonucleoside + phosphate => a ribonucleoside 3'-phosphate + H2O"}
{"X":13597,"RHEA_ID":10148,"DIRECTION":"UN","MASTER_ID":10148,"ec":"3.5.4.23","compounds":"blasticidin S + H(+) + H2O = deaminohydroxyblasticidin S + NH4(+)"}
{"X":13598,"RHEA_ID":10149,"compounds":"blasticidin S + H(+) + H2O => deaminohydroxyblasticidin S + NH4(+)"}
{"X":13599,"RHEA_ID":10150,"compounds":"deaminohydroxyblasticidin S + NH4(+) => blasticidin S + H(+) + H2O"}
{"X":13600,"RHEA_ID":19993,"DIRECTION":"UN","MASTER_ID":19993,"ec":"1.8.4.13","compounds":"[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide"}
{"X":13601,"RHEA_ID":10152,"DIRECTION":"UN","MASTER_ID":10152,"ec":"2.7.2.2","compounds":"ATP + hydrogencarbonate + NH4(+) = ADP + carbamoyl phosphate + H(+) + H2O"}
{"X":13602,"RHEA_ID":10153,"compounds":"ATP + hydrogencarbonate + NH4(+) => ADP + carbamoyl phosphate + H(+) + H2O"}
{"X":13603,"RHEA_ID":10154,"compounds":"ADP + carbamoyl phosphate + H(+) + H2O => ATP + hydrogencarbonate + NH4(+)"}
{"X":13604,"RHEA_ID":30553,"compounds":"6-O-acetyl-beta-D-glucose + CoA => acetyl-CoA + beta-D-glucose"}
{"X":13605,"RHEA_ID":10156,"DIRECTION":"UN","MASTER_ID":10156,"ec":"1.14.14.101","compounds":"dihydrochelirubine + O2 + reduced [NADPH--hemoprotein reductase] = 12-hydroxydihydrochelirubine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":13606,"RHEA_ID":10157,"DIRECTION":"LR","MASTER_ID":10156,"metacyc":"1.14.13.57-RXN","compounds":"dihydrochelirubine + O2 + reduced [NADPH--hemoprotein reductase] => 12-hydroxydihydrochelirubine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":13607,"RHEA_ID":10158,"compounds":"12-hydroxydihydrochelirubine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dihydrochelirubine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":13608,"RHEA_ID":10160,"DIRECTION":"UN","MASTER_ID":10160,"ec":"1.1.1.14","compounds":"L-iditol + NAD(+) = H(+) + keto-L-sorbose + NADH"}
{"X":13609,"RHEA_ID":10161,"compounds":"L-iditol + NAD(+) => H(+) + keto-L-sorbose + NADH"}
{"X":13610,"RHEA_ID":10162,"compounds":"H(+) + keto-L-sorbose + NADH => L-iditol + NAD(+)"}
{"X":13611,"RHEA_ID":10164,"DIRECTION":"UN","MASTER_ID":10164,"ec":"4.2.1.11","compounds":"(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate"}
{"X":13612,"RHEA_ID":10165,"DIRECTION":"LR","MASTER_ID":10164,"macie":"M0311","reactome":"R-HSA-71660.2","compounds":"(2R)-2-phosphoglycerate => H2O + phosphoenolpyruvate"}
{"X":13613,"RHEA_ID":10166,"DIRECTION":"RL","MASTER_ID":10164,"reactome":"R-HSA-70494.2","compounds":"H2O + phosphoenolpyruvate => (2R)-2-phosphoglycerate"}
{"X":13614,"RHEA_ID":10168,"DIRECTION":"UN","MASTER_ID":10168,"ec":"1.3.7.2","compounds":"15,16-dihydrobiliverdin + oxidized 2[4Fe-4S]-[ferredoxin] = biliverdin IXalpha + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]"}
{"X":13615,"RHEA_ID":10169,"compounds":"15,16-dihydrobiliverdin + oxidized 2[4Fe-4S]-[ferredoxin] => biliverdin IXalpha + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]"}
{"X":13616,"RHEA_ID":10170,"DIRECTION":"RL","MASTER_ID":10168,"metacyc":"1.3.7.2-RXN","compounds":"biliverdin IXalpha + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] => 15,16-dihydrobiliverdin + oxidized 2[4Fe-4S]-[ferredoxin]"}
{"X":13617,"RHEA_ID":30569,"compounds":"5,6,7,8-tetrahydrosarcinapterin + ADP + H(+) + phosphate => 5,6,7,8-tetrahydromethanopterin + ATP + L-glutamate"}
{"X":13618,"RHEA_ID":10172,"DIRECTION":"UN","MASTER_ID":10172,"ec":"3.1.1.22","compounds":"(3R)-hydroxybutanoate dimer + H2O = 2 (R)-3-hydroxybutanoate + H(+)"}
{"X":13619,"RHEA_ID":10173,"DIRECTION":"LR","MASTER_ID":10172,"metacyc":"HYDROXYBUTYRATE-DIMER-HYDROLASE-RXN","compounds":"(3R)-hydroxybutanoate dimer + H2O => 2 (R)-3-hydroxybutanoate + H(+)"}
{"X":13620,"RHEA_ID":10174,"compounds":"2 (R)-3-hydroxybutanoate + H(+) => (3R)-hydroxybutanoate dimer + H2O"}
{"X":13621,"RHEA_ID":30573,"compounds":"6 AMP + 6 diphosphate + enterobactin + 4 H(+) => 3 2,3-dihydroxybenzoate + 6 ATP + 3 L-serine"}
{"X":13622,"RHEA_ID":10176,"DIRECTION":"UN","MASTER_ID":10176,"ec":"1.1.1.397","compounds":"(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD(+) = (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + NADH"}
{"X":13623,"RHEA_ID":10177,"compounds":"(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD(+) => (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + NADH"}
{"X":13624,"RHEA_ID":10178,"DIRECTION":"RL","MASTER_ID":10176,"metacyc":"RXN-17529","compounds":"(R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + NADH => (2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD(+)"}
{"X":13625,"RHEA_ID":10180,"DIRECTION":"UN","MASTER_ID":10180,"ec":"1.5.1.6","metacyc":"FORMYLTETRAHYDROFOLATE-DEHYDROGENASE-RXN","compounds":"(6S)-10-formyltetrahydrofolate + H2O + NADP(+) = (6S)-5,6,7,8-tetrahydrofolate + CO2 + H(+) + NADPH"}
{"X":13626,"RHEA_ID":10181,"compounds":"(6S)-10-formyltetrahydrofolate + H2O + NADP(+) => (6S)-5,6,7,8-tetrahydrofolate + CO2 + H(+) + NADPH"}
{"X":13627,"RHEA_ID":10182,"compounds":"(6S)-5,6,7,8-tetrahydrofolate + CO2 + H(+) + NADPH => (6S)-10-formyltetrahydrofolate + H2O + NADP(+)"}
{"X":13628,"RHEA_ID":30581,"compounds":"L-threonine + phosphate => H2O + O-phospho-L-threonine"}
{"X":13629,"RHEA_ID":10184,"DIRECTION":"UN","MASTER_ID":10184,"ec":"3.1.1.24","compounds":"(4,5-dihydro-5-oxofuran-2-yl)-acetate + H2O = 3-oxoadipate + H(+)"}
{"X":13630,"RHEA_ID":10185,"DIRECTION":"LR","MASTER_ID":10184,"metacyc":"3-OXOADIPATE-ENOL-LACTONASE-RXN","compounds":"(4,5-dihydro-5-oxofuran-2-yl)-acetate + H2O => 3-oxoadipate + H(+)"}
{"X":13631,"RHEA_ID":10186,"compounds":"3-oxoadipate + H(+) => (4,5-dihydro-5-oxofuran-2-yl)-acetate + H2O"}
{"X":13632,"RHEA_ID":30585,"compounds":"2-demethylmenaquinone-8 + H2O + trimethylamine => 2-demethylmenaquinol-8 + H(+) + trimethylamine N-oxide"}
{"X":13633,"RHEA_ID":10188,"DIRECTION":"UN","MASTER_ID":10188,"ec":"2.3.3.10","compounds":"acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-hydroxy-3-methylglutaryl-CoA + CoA + H(+)"}
{"X":13634,"RHEA_ID":10189,"compounds":"acetoacetyl-CoA + acetyl-CoA + H2O => (3S)-hydroxy-3-methylglutaryl-CoA + CoA + H(+)"}
{"X":13635,"RHEA_ID":10190,"compounds":"(3S)-hydroxy-3-methylglutaryl-CoA + CoA + H(+) => acetoacetyl-CoA + acetyl-CoA + H2O"}
{"X":13636,"RHEA_ID":30589,"compounds":"2-demethylmenaquinone-8 + dimethyl sulfide + H2O => 2-demethylmenaquinol-8 + dimethyl sulfoxide"}
{"X":13637,"RHEA_ID":10192,"DIRECTION":"UN","MASTER_ID":10192,"ec":"7.3.2.3","compounds":"ATP + H2O + sulfate(out) = ADP + H(+) + phosphate + sulfate(in)"}
{"X":13638,"RHEA_ID":10193,"DIRECTION":"LR","MASTER_ID":10192,"ecocyc":"ABC-70-RXN","metacyc":"3.6.3.25-RXN","compounds":"ATP + H2O + sulfate(out) => ADP + H(+) + phosphate + sulfate(in)"}
{"X":13639,"RHEA_ID":10194,"compounds":"ADP + H(+) + phosphate + sulfate(in) => ATP + H2O + sulfate(out)"}
{"X":13640,"RHEA_ID":10195,"compounds":"ATP + H2O + sulfate(out) <=> ADP + H(+) + phosphate + sulfate(in)"}
{"X":13641,"RHEA_ID":10196,"DIRECTION":"UN","MASTER_ID":10196,"ec":"4.2.1.113","compounds":"(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H2O"}
{"X":13642,"RHEA_ID":10197,"DIRECTION":"LR","MASTER_ID":10196,"ecocyc":"O-SUCCINYLBENZOATE-COA-SYN-RXN","metacyc":"O-SUCCINYLBENZOATE-COA-SYN-RXN","compounds":"(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate => 2-succinylbenzoate + H2O"}
{"X":13643,"RHEA_ID":10198,"compounds":"2-succinylbenzoate + H2O => (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate"}
{"X":13644,"RHEA_ID":30596,"DIRECTION":"LR","MASTER_ID":30595,"metacyc":"RXN-8505","compounds":"4-hydroxyphenylacetate + FADH2 + O2 => 3,4-dihydroxyphenylacetate + FAD + H(+) + H2O"}
{"X":13645,"RHEA_ID":10200,"DIRECTION":"UN","MASTER_ID":10200,"ec":"1.3.1.31","compounds":"butanoate + NAD(+) = (2E)-2-butenoate + H(+) + NADH"}
{"X":13646,"RHEA_ID":10201,"compounds":"butanoate + NAD(+) => (2E)-2-butenoate + H(+) + NADH"}
{"X":13647,"RHEA_ID":10202,"compounds":"(2E)-2-butenoate + H(+) + NADH => butanoate + NAD(+)"}
{"X":13648,"RHEA_ID":10204,"DIRECTION":"UN","MASTER_ID":10204,"ec":"1.5.8.1","compounds":"dimethylamine + H(+) + H2O + oxidized [electron-transfer flavoprotein] = formaldehyde + methylamine + reduced [electron-transfer flavoprotein]"}
{"X":13649,"RHEA_ID":10205,"compounds":"dimethylamine + H(+) + H2O + oxidized [electron-transfer flavoprotein] => formaldehyde + methylamine + reduced [electron-transfer flavoprotein]"}
{"X":13650,"RHEA_ID":10206,"compounds":"formaldehyde + methylamine + reduced [electron-transfer flavoprotein] => dimethylamine + H(+) + H2O + oxidized [electron-transfer flavoprotein]"}
{"X":13651,"RHEA_ID":10208,"DIRECTION":"UN","MASTER_ID":10208,"ec":"2.3.2.8","compounds":"an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) = H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg)"}
{"X":13652,"RHEA_ID":10209,"compounds":"an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) => H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg)"}
{"X":13653,"RHEA_ID":10210,"compounds":"H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg) => an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg)"}
{"X":13654,"RHEA_ID":10212,"DIRECTION":"UN","MASTER_ID":10212,"ec":"2.6.1.48","compounds":"2-oxoglutarate + 5-aminopentanoate = 5-oxopentanoate + L-glutamate"}
{"X":13655,"RHEA_ID":10213,"compounds":"2-oxoglutarate + 5-aminopentanoate => 5-oxopentanoate + L-glutamate"}
{"X":13656,"RHEA_ID":10214,"compounds":"5-oxopentanoate + L-glutamate => 2-oxoglutarate + 5-aminopentanoate"}
{"X":13657,"RHEA_ID":30612,"DIRECTION":"LR","MASTER_ID":30611,"metacyc":"RXN-8022","compounds":"A + all-trans-zeta-carotene => AH2 + all-trans-neurosporene"}
{"X":13658,"RHEA_ID":10216,"DIRECTION":"UN","MASTER_ID":10216,"ec":"2.7.11.23","compounds":"[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase]"}
{"X":13659,"RHEA_ID":10217,"compounds":"[DNA-directed RNA polymerase] + ATP => ADP + H(+) + phospho-[DNA-directed RNA polymerase]"}
{"X":13660,"RHEA_ID":10218,"compounds":"ADP + H(+) + phospho-[DNA-directed RNA polymerase] => [DNA-directed RNA polymerase] + ATP"}
{"X":13661,"RHEA_ID":10220,"DIRECTION":"UN","MASTER_ID":10220,"ec":"6.1.1.1","compounds":"ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)"}
{"X":13662,"RHEA_ID":10221,"DIRECTION":"LR","MASTER_ID":10220,"ecocyc":"TYROSINE--TRNA-LIGASE-RXN","metacyc":"TYROSINE--TRNA-LIGASE-RXN","compounds":"ATP + L-tyrosine + tRNA(Tyr) => AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)"}
{"X":13663,"RHEA_ID":10222,"compounds":"AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr) => ATP + L-tyrosine + tRNA(Tyr)"}
{"X":13664,"RHEA_ID":30620,"compounds":"2 A + all-trans-zeta-carotene => 2 AH2 + all-trans-lycopene"}
{"X":13665,"RHEA_ID":10224,"DIRECTION":"UN","MASTER_ID":10224,"ec":"2.7.1.35","compounds":"ATP + pyridoxal = ADP + H(+) + pyridoxal 5'-phosphate"}
{"X":13666,"RHEA_ID":10225,"DIRECTION":"LR","MASTER_ID":10224,"ecocyc":"PYRIDOXKIN-RXN","metacyc":"PYRIDOXKIN-RXN","reactome":"R-HSA-964970.1","compounds":"ATP + pyridoxal => ADP + H(+) + pyridoxal 5'-phosphate"}
{"X":13667,"RHEA_ID":10226,"compounds":"ADP + H(+) + pyridoxal 5'-phosphate => ATP + pyridoxal"}
{"X":13668,"RHEA_ID":30624,"DIRECTION":"LR","MASTER_ID":30623,"metacyc":"RXN-12412","compounds":"A + all-trans-neurosporene => AH2 + all-trans-lycopene"}
{"X":13669,"RHEA_ID":10228,"compounds":"citrate = cis-aconitate + H2O"}
{"X":13670,"RHEA_ID":10229,"compounds":"citrate => cis-aconitate + H2O"}
{"X":13671,"RHEA_ID":10230,"compounds":"cis-aconitate + H2O => citrate"}
{"X":13672,"RHEA_ID":30627,"DIRECTION":"UN","MASTER_ID":30627,"ec":"1.1.1.383","compounds":"(2R)-2,3-dihydroxy-3-methylbutanoate + NAD(+) = (2S)-2-acetolactate + H(+) + NADH"}
{"X":13673,"RHEA_ID":10232,"DIRECTION":"UN","MASTER_ID":10232,"ec":"2.4.2.20","metacyc":"2.4.2.20-RXN","compounds":"5,6-dihydrouridine 5'-monophosphate + diphosphate = 5,6-dihydrouracil + 5-phospho-alpha-D-ribose 1-diphosphate"}
{"X":13674,"RHEA_ID":10233,"compounds":"5,6-dihydrouridine 5'-monophosphate + diphosphate => 5,6-dihydrouracil + 5-phospho-alpha-D-ribose 1-diphosphate"}
{"X":13675,"RHEA_ID":10234,"compounds":"5,6-dihydrouracil + 5-phospho-alpha-D-ribose 1-diphosphate => 5,6-dihydrouridine 5'-monophosphate + diphosphate"}
{"X":13676,"RHEA_ID":10236,"DIRECTION":"UN","MASTER_ID":10236,"ec":"2.4.1.114","compounds":"trans-2-coumarate + UDP-alpha-D-glucose = H(+) + trans-beta-D-glucosyl-2-hydroxycinnamate + UDP"}
{"X":13677,"RHEA_ID":10237,"DIRECTION":"LR","MASTER_ID":10236,"metacyc":"2.4.1.114-RXN","compounds":"trans-2-coumarate + UDP-alpha-D-glucose => H(+) + trans-beta-D-glucosyl-2-hydroxycinnamate + UDP"}
{"X":13678,"RHEA_ID":10238,"compounds":"H(+) + trans-beta-D-glucosyl-2-hydroxycinnamate + UDP => trans-2-coumarate + UDP-alpha-D-glucose"}
{"X":13679,"RHEA_ID":40603,"compounds":"1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O = (9Z,12Z)-octadecadienoate + glycerol + H(+)"}
{"X":13680,"RHEA_ID":10240,"DIRECTION":"UN","MASTER_ID":10240,"ec":"1.3.1.9","compounds":"a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + H(+) + NADH"}
{"X":13681,"RHEA_ID":10241,"compounds":"a 2,3-saturated acyl-[ACP] + NAD(+) => a (2E)-enoyl-[ACP] + H(+) + NADH"}
{"X":13682,"RHEA_ID":10242,"DIRECTION":"RL","MASTER_ID":10240,"ecocyc":"1.3.1.9-RXN","metacyc":"1.3.1.9-RXN","compounds":"a (2E)-enoyl-[ACP] + H(+) + NADH => a 2,3-saturated acyl-[ACP] + NAD(+)"}
{"X":13683,"RHEA_ID":10244,"DIRECTION":"UN","MASTER_ID":10244,"ec":"3.7.1.2","compounds":"4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)"}
{"X":13684,"RHEA_ID":10245,"DIRECTION":"LR","MASTER_ID":10244,"macie":"M0180","metacyc":"FUMARYLACETOACETASE-RXN","reactome":"R-HSA-71181.4","compounds":"4-fumarylacetoacetate + H2O => acetoacetate + fumarate + H(+)"}
{"X":13685,"RHEA_ID":10246,"compounds":"acetoacetate + fumarate + H(+) => 4-fumarylacetoacetate + H2O"}
{"X":13686,"RHEA_ID":40611,"compounds":"H2O + trihexanoylglycerol = 2,3-dihexanoyl-sn-glycerol + H(+) + hexanoate"}
{"X":13687,"RHEA_ID":10248,"DIRECTION":"UN","MASTER_ID":10248,"ec":"3.6.1.9","compounds":"dUTP + H2O = diphosphate + dUMP + H(+)"}
{"X":13688,"RHEA_ID":10248,"DIRECTION":"UN","MASTER_ID":10248,"ec":"3.6.1.23","compounds":"dUTP + H2O = diphosphate + dUMP + H(+)"}
{"X":13689,"RHEA_ID":10249,"DIRECTION":"LR","MASTER_ID":10248,"ecocyc":"DUTP-PYROP-RXN","metacyc":"DUTP-PYROP-RXN","reactome":"R-HSA-73666.3","compounds":"dUTP + H2O => diphosphate + dUMP + H(+)"}
{"X":13690,"RHEA_ID":10250,"compounds":"diphosphate + dUMP + H(+) => dUTP + H2O"}
{"X":13691,"RHEA_ID":20093,"DIRECTION":"UN","MASTER_ID":20093,"ec":"2.4.1.115","compounds":"an anthocyanidin + H(+) + UDP-alpha-D-glucose = an anthocyanidin 3-O-beta-D-glucoside + UDP"}
{"X":13692,"RHEA_ID":10252,"DIRECTION":"UN","MASTER_ID":10252,"ec":"2.5.1.65","compounds":"H(+) + hydrogen sulfide + O-phospho-L-serine = L-cysteine + phosphate"}
{"X":13693,"RHEA_ID":10253,"compounds":"H(+) + hydrogen sulfide + O-phospho-L-serine => L-cysteine + phosphate"}
{"X":13694,"RHEA_ID":10254,"compounds":"L-cysteine + phosphate => H(+) + hydrogen sulfide + O-phospho-L-serine"}
{"X":13695,"RHEA_ID":20097,"DIRECTION":"UN","MASTER_ID":20097,"ec":"4.2.1.8","compounds":"D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O"}
{"X":13696,"RHEA_ID":10256,"DIRECTION":"UN","MASTER_ID":10256,"ec":"2.7.9.5","compounds":"[(1->4)-6-phospho-alpha-D-glucosyl](n) + n ATP + n H2O = [(1->4)-3,6-bisphospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate"}
{"X":13697,"RHEA_ID":10257,"DIRECTION":"LR","MASTER_ID":10256,"metacyc":"2.7.9.5-RXN","compounds":"[(1->4)-6-phospho-alpha-D-glucosyl](n) + n ATP + n H2O => [(1->4)-3,6-bisphospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate"}
{"X":13698,"RHEA_ID":10258,"compounds":"[(1->4)-3,6-bisphospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate => [(1->4)-6-phospho-alpha-D-glucosyl](n) + n ATP + n H2O"}
{"X":13699,"RHEA_ID":10259,"compounds":"[(1->4)-6-phospho-alpha-D-glucosyl](n) + n ATP + n H2O <=> [(1->4)-3,6-bisphospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate"}
{"X":13700,"RHEA_ID":10260,"DIRECTION":"UN","MASTER_ID":10260,"ec":"7.2.2.14","compounds":"ATP + H2O + Mg(2+)(out) = ADP + H(+) + Mg(2+)(in) + phosphate"}
{"X":13701,"RHEA_ID":10261,"DIRECTION":"LR","MASTER_ID":10260,"ecocyc":"TRANS-RXN-250","metacyc":"3.6.3.2-RXN","compounds":"ATP + H2O + Mg(2+)(out) => ADP + H(+) + Mg(2+)(in) + phosphate"}
{"X":13702,"RHEA_ID":10262,"compounds":"ADP + H(+) + Mg(2+)(in) + phosphate => ATP + H2O + Mg(2+)(out)"}
{"X":13703,"RHEA_ID":10263,"compounds":"ATP + H2O + Mg(2+)(out) <=> ADP + H(+) + Mg(2+)(in) + phosphate"}
{"X":13704,"RHEA_ID":10264,"DIRECTION":"UN","MASTER_ID":10264,"ec":"5.1.3.3","compounds":"alpha-D-glucose = beta-D-glucose"}
{"X":13705,"RHEA_ID":10265,"compounds":"alpha-D-glucose => beta-D-glucose"}
{"X":13706,"RHEA_ID":10266,"compounds":"beta-D-glucose => alpha-D-glucose"}
{"X":13707,"RHEA_ID":20109,"DIRECTION":"UN","MASTER_ID":20109,"ec":"2.7.4.23","compounds":"alpha-D-ribose 1,5-bisphosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + ADP"}
{"X":13708,"RHEA_ID":10268,"DIRECTION":"UN","MASTER_ID":10268,"ec":"4.1.2.20","compounds":"2-dehydro-3-deoxy-D-glucarate = 2-hydroxy-3-oxopropanoate + pyruvate"}
{"X":13709,"RHEA_ID":10269,"compounds":"2-dehydro-3-deoxy-D-glucarate => 2-hydroxy-3-oxopropanoate + pyruvate"}
{"X":13710,"RHEA_ID":10270,"compounds":"2-hydroxy-3-oxopropanoate + pyruvate => 2-dehydro-3-deoxy-D-glucarate"}
{"X":13711,"RHEA_ID":20113,"DIRECTION":"UN","MASTER_ID":20113,"ec":"5.4.2.6","compounds":"beta-D-glucose 1-phosphate = beta-D-glucose 6-phosphate"}
{"X":13712,"RHEA_ID":10272,"DIRECTION":"UN","MASTER_ID":10272,"ec":"2.7.1.107","compounds":"a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":13713,"RHEA_ID":10273,"compounds":"a 1,2-diacyl-sn-glycerol + ATP => a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":13714,"RHEA_ID":10274,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+) => a 1,2-diacyl-sn-glycerol + ATP"}
{"X":13715,"RHEA_ID":20117,"DIRECTION":"UN","MASTER_ID":20117,"ec":"2.7.1.5","compounds":"ATP + L-rhamnulose = ADP + H(+) + L-rhamnulose 1-phosphate"}
{"X":13716,"RHEA_ID":10276,"DIRECTION":"UN","MASTER_ID":10276,"ec":"2.7.4.24","compounds":"5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP"}
{"X":13717,"RHEA_ID":10277,"DIRECTION":"LR","MASTER_ID":10276,"metacyc":"2.7.4.24-RXN","reactome":"R-HSA-1855182.2","compounds":"5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) => 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP"}
{"X":13718,"RHEA_ID":10278,"compounds":"1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP => 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+)"}
{"X":13719,"RHEA_ID":20121,"DIRECTION":"UN","MASTER_ID":20121,"ec":"6.1.1.18","compounds":"ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)"}
{"X":13720,"RHEA_ID":10280,"DIRECTION":"UN","MASTER_ID":10280,"ec":"2.1.1.160","compounds":"1,7-dimethylxanthine + S-adenosyl-L-methionine = caffeine + H(+) + S-adenosyl-L-homocysteine"}
{"X":13721,"RHEA_ID":10281,"DIRECTION":"LR","MASTER_ID":10280,"metacyc":"RXN-7601","compounds":"1,7-dimethylxanthine + S-adenosyl-L-methionine => caffeine + H(+) + S-adenosyl-L-homocysteine"}
{"X":13722,"RHEA_ID":10282,"compounds":"caffeine + H(+) + S-adenosyl-L-homocysteine => 1,7-dimethylxanthine + S-adenosyl-L-methionine"}
{"X":13723,"RHEA_ID":20125,"DIRECTION":"UN","MASTER_ID":20125,"ec":"1.18.1.7","compounds":"H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":13724,"RHEA_ID":10284,"DIRECTION":"UN","MASTER_ID":10284,"ec":"5.4.3.7","compounds":"L-leucine = (3R)-beta-leucine"}
{"X":13725,"RHEA_ID":10285,"compounds":"L-leucine => (3R)-beta-leucine"}
{"X":13726,"RHEA_ID":10286,"compounds":"(3R)-beta-leucine => L-leucine"}
{"X":13727,"RHEA_ID":10288,"DIRECTION":"UN","MASTER_ID":10288,"ec":"3.1.1.65","compounds":"H2O + L-rhamnono-1,4-lactone = H(+) + L-rhamnonate"}
{"X":13728,"RHEA_ID":10289,"DIRECTION":"LR","MASTER_ID":10288,"metacyc":"L-RHAMNONO-14-LACTONASE-RXN","compounds":"H2O + L-rhamnono-1,4-lactone => H(+) + L-rhamnonate"}
{"X":13729,"RHEA_ID":10290,"compounds":"H(+) + L-rhamnonate => H2O + L-rhamnono-1,4-lactone"}
{"X":13730,"RHEA_ID":30687,"compounds":"(4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate"}
{"X":13731,"RHEA_ID":10292,"DIRECTION":"UN","MASTER_ID":10292,"ec":"2.3.1.4","compounds":"acetyl-CoA + D-glucosamine 6-phosphate = CoA + H(+) + N-acetyl-D-glucosamine 6-phosphate"}
{"X":13732,"RHEA_ID":10293,"DIRECTION":"LR","MASTER_ID":10292,"metacyc":"GLUCOSAMINEPNACETYLTRANS-RXN","compounds":"acetyl-CoA + D-glucosamine 6-phosphate => CoA + H(+) + N-acetyl-D-glucosamine 6-phosphate"}
{"X":13733,"RHEA_ID":10294,"compounds":"CoA + H(+) + N-acetyl-D-glucosamine 6-phosphate => acetyl-CoA + D-glucosamine 6-phosphate"}
{"X":13734,"RHEA_ID":10296,"DIRECTION":"UN","MASTER_ID":10296,"ec":"1.2.1.13","compounds":"D-glyceraldehyde 3-phosphate + NADP(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADPH"}
{"X":13735,"RHEA_ID":10296,"DIRECTION":"UN","MASTER_ID":10296,"ec":"1.2.1.59","compounds":"D-glyceraldehyde 3-phosphate + NADP(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADPH"}
{"X":13736,"RHEA_ID":10297,"compounds":"D-glyceraldehyde 3-phosphate + NADP(+) + phosphate => (2R)-3-phospho-glyceroyl phosphate + H(+) + NADPH"}
{"X":13737,"RHEA_ID":10298,"DIRECTION":"RL","MASTER_ID":10296,"metacyc":"1.2.1.13-RXN","compounds":"(2R)-3-phospho-glyceroyl phosphate + H(+) + NADPH => D-glyceraldehyde 3-phosphate + NADP(+) + phosphate"}
{"X":13738,"RHEA_ID":20141,"DIRECTION":"UN","MASTER_ID":20141,"ec":"4.4.1.4","compounds":"an S-alkyl-L-cysteine S-oxide = 2-aminoprop-2-enoate + an S-alkyl sulfenate"}
{"X":13739,"RHEA_ID":10300,"DIRECTION":"UN","MASTER_ID":10300,"ec":"1.2.1.12","compounds":"D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH"}
{"X":13740,"RHEA_ID":10300,"DIRECTION":"UN","MASTER_ID":10300,"ec":"1.2.1.59","compounds":"D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH"}
{"X":13741,"RHEA_ID":10301,"DIRECTION":"LR","MASTER_ID":10300,"reactome":"R-HSA-70449.3","compounds":"D-glyceraldehyde 3-phosphate + NAD(+) + phosphate => (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH"}
{"X":13742,"RHEA_ID":10302,"DIRECTION":"RL","MASTER_ID":10300,"reactome":"R-HSA-70482.3","compounds":"(2R)-3-phospho-glyceroyl phosphate + H(+) + NADH => D-glyceraldehyde 3-phosphate + NAD(+) + phosphate"}
{"X":13743,"RHEA_ID":20146,"DIRECTION":"LR","MASTER_ID":20145,"metacyc":"RXN-11370","compounds":"2-(3-amino-3-carboxypropyl)-L-histidine + S-adenosyl-L-methionine => 2-[3-carboxy-3-(methylammonio)propyl]-L-histidine + H(+) + S-adenosyl-L-homocysteine"}
{"X":13744,"RHEA_ID":20147,"compounds":"2-[3-carboxy-3-(methylammonio)propyl]-L-histidine + H(+) + S-adenosyl-L-homocysteine => 2-(3-amino-3-carboxypropyl)-L-histidine + S-adenosyl-L-methionine"}
{"X":13745,"RHEA_ID":10304,"DIRECTION":"UN","MASTER_ID":10304,"ec":"2.3.1.40","compounds":"a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-[ACP] = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + holo-[ACP]"}
{"X":13746,"RHEA_ID":10305,"compounds":"a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-[ACP] => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + holo-[ACP]"}
{"X":13747,"RHEA_ID":10306,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + holo-[ACP] => a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-[ACP]"}
{"X":13748,"RHEA_ID":10312,"DIRECTION":"UN","MASTER_ID":10312,"ec":"1.14.12.15","compounds":"H(+) + NADH + O2 + terephthalate = (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+)"}
{"X":13749,"RHEA_ID":10313,"DIRECTION":"LR","MASTER_ID":10312,"metacyc":"1.14.12.15-RXN","compounds":"H(+) + NADH + O2 + terephthalate => (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+)"}
{"X":13750,"RHEA_ID":10314,"compounds":"(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+) => H(+) + NADH + O2 + terephthalate"}
{"X":13751,"RHEA_ID":20155,"compounds":"ADP + beta-L-arabinose 1-phosphate + H(+) => ATP + L-arabinose"}
{"X":13752,"RHEA_ID":10316,"DIRECTION":"UN","MASTER_ID":10316,"ec":"1.14.11.6","compounds":"2-oxoglutarate + O2 + thymine = 5-hydroxymethyluracil + CO2 + succinate"}
{"X":13753,"RHEA_ID":10317,"DIRECTION":"LR","MASTER_ID":10316,"metacyc":"THYMINE-DIOXYGENASE-RXN","compounds":"2-oxoglutarate + O2 + thymine => 5-hydroxymethyluracil + CO2 + succinate"}
{"X":13754,"RHEA_ID":10318,"compounds":"5-hydroxymethyluracil + CO2 + succinate => 2-oxoglutarate + O2 + thymine"}
{"X":13755,"RHEA_ID":20159,"compounds":"2n [Fe(II)cytochrome c] + an oxidized polyvinyl alcohol + 2n H(+) => 2n [Fe(III)cytochrome c] + a polyvinyl alcohol"}
{"X":13756,"RHEA_ID":10320,"DIRECTION":"UN","MASTER_ID":10320,"ec":"4.2.1.77","compounds":"trans-3-hydroxy-L-proline = 1-pyrroline-2-carboxylate + H2O"}
{"X":13757,"RHEA_ID":10321,"DIRECTION":"LR","MASTER_ID":10320,"metacyc":"TRANS-L-3-HYDROXYPROLINE-DEHYDRATASE-RXN","compounds":"trans-3-hydroxy-L-proline => 1-pyrroline-2-carboxylate + H2O"}
{"X":13758,"RHEA_ID":10322,"compounds":"1-pyrroline-2-carboxylate + H2O => trans-3-hydroxy-L-proline"}
{"X":13759,"RHEA_ID":20163,"compounds":"myo-inositol + raffinose => alpha-D-galactosyl-(1->3)-1D-myo-inositol + sucrose"}
{"X":13760,"RHEA_ID":10324,"DIRECTION":"UN","MASTER_ID":10324,"ec":"1.1.1.185","metacyc":"L-GLYCOL-DEHYDROGENASE-RXN","compounds":"an L-glycol + NADP(+) = a 2-hydroxycarbonyl + H(+) + NADPH"}
{"X":13761,"RHEA_ID":10325,"compounds":"an L-glycol + NADP(+) => a 2-hydroxycarbonyl + H(+) + NADPH"}
{"X":13762,"RHEA_ID":10326,"compounds":"a 2-hydroxycarbonyl + H(+) + NADPH => an L-glycol + NADP(+)"}
{"X":13763,"RHEA_ID":10328,"DIRECTION":"UN","MASTER_ID":10328,"ec":"1.1.1.185","metacyc":"L-GLYCOL-DEHYDROGENASE-RXN","compounds":"an L-glycol + NAD(+) = a 2-hydroxycarbonyl + H(+) + NADH"}
{"X":13764,"RHEA_ID":10329,"compounds":"an L-glycol + NAD(+) => a 2-hydroxycarbonyl + H(+) + NADH"}
{"X":13765,"RHEA_ID":10330,"compounds":"a 2-hydroxycarbonyl + H(+) + NADH => an L-glycol + NAD(+)"}
{"X":13766,"RHEA_ID":10332,"DIRECTION":"UN","MASTER_ID":10332,"ec":"2.3.1.62","metacyc":"2.3.1.62-RXN","compounds":"a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA"}
{"X":13767,"RHEA_ID":10333,"compounds":"a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA"}
{"X":13768,"RHEA_ID":10334,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA => a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA"}
{"X":13769,"RHEA_ID":10336,"DIRECTION":"UN","MASTER_ID":10336,"ec":"4.2.1.3","compounds":"citrate = isocitrate"}
{"X":13770,"RHEA_ID":10337,"compounds":"citrate => isocitrate"}
{"X":13771,"RHEA_ID":10338,"compounds":"isocitrate => citrate"}
{"X":13772,"RHEA_ID":20179,"compounds":"5'-O-beta-D-glucosylpyridoxine + H(+) + UDP => pyridoxine + UDP-alpha-D-glucose"}
{"X":13773,"RHEA_ID":10340,"DIRECTION":"UN","MASTER_ID":10340,"ec":"4.2.3.21","compounds":"(2E,6E)-farnesyl diphosphate = (-)-vetispiradiene + diphosphate"}
{"X":13774,"RHEA_ID":10341,"DIRECTION":"LR","MASTER_ID":10340,"metacyc":"RXN-4823","compounds":"(2E,6E)-farnesyl diphosphate => (-)-vetispiradiene + diphosphate"}
{"X":13775,"RHEA_ID":10342,"compounds":"(-)-vetispiradiene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":13776,"RHEA_ID":20183,"compounds":"6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H(+) + UMP => alpha-D-mannose derivative + UDP-alpha-D-glucose"}
{"X":13777,"RHEA_ID":10344,"DIRECTION":"UN","MASTER_ID":10344,"ec":"2.3.1.25","compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA"}
{"X":13778,"RHEA_ID":10345,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA"}
{"X":13779,"RHEA_ID":10346,"compounds":"1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA"}
{"X":13780,"RHEA_ID":10348,"DIRECTION":"UN","MASTER_ID":10348,"ec":"3.5.2.9","compounds":"5-oxo-L-proline + ATP + 2 H2O = ADP + H(+) + L-glutamate + phosphate"}
{"X":13781,"RHEA_ID":10349,"DIRECTION":"LR","MASTER_ID":10348,"metacyc":"5-OXOPROLINASE-ATP-HYDROLYSING-RXN","reactome":"R-HSA-1247935.2","compounds":"5-oxo-L-proline + ATP + 2 H2O => ADP + H(+) + L-glutamate + phosphate"}
{"X":13782,"RHEA_ID":10350,"compounds":"ADP + H(+) + L-glutamate + phosphate => 5-oxo-L-proline + ATP + 2 H2O"}
{"X":13783,"RHEA_ID":30747,"compounds":"FAD + H(+) + hexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + FADH2"}
{"X":13784,"RHEA_ID":10352,"DIRECTION":"UN","MASTER_ID":10352,"ec":"3.5.1.76","compounds":"an N-acetylarylalkylamine + H2O = acetate + an arylalkylamine"}
{"X":13785,"RHEA_ID":10353,"compounds":"an N-acetylarylalkylamine + H2O => acetate + an arylalkylamine"}
{"X":13786,"RHEA_ID":10354,"compounds":"acetate + an arylalkylamine => an N-acetylarylalkylamine + H2O"}
{"X":13787,"RHEA_ID":10356,"DIRECTION":"UN","MASTER_ID":10356,"ec":"1.1.1.152","metacyc":"1.1.1.152-RXN","compounds":"3alpha-hydroxy-5beta-androstan-17-one + NAD(+) = 5beta-androstane-3,17-dione + H(+) + NADH"}
{"X":13788,"RHEA_ID":10357,"compounds":"3alpha-hydroxy-5beta-androstan-17-one + NAD(+) => 5beta-androstane-3,17-dione + H(+) + NADH"}
{"X":13789,"RHEA_ID":10358,"compounds":"5beta-androstane-3,17-dione + H(+) + NADH => 3alpha-hydroxy-5beta-androstan-17-one + NAD(+)"}
{"X":13790,"RHEA_ID":10360,"DIRECTION":"UN","MASTER_ID":10360,"ec":"3.1.1.35","compounds":"3,4-dihydrocoumarin + H2O = 3-(2-hydroxyphenyl)propanoate + H(+)"}
{"X":13791,"RHEA_ID":10361,"DIRECTION":"LR","MASTER_ID":10360,"metacyc":"DIHYDROCOUMARIN-LIPASE-RXN","compounds":"3,4-dihydrocoumarin + H2O => 3-(2-hydroxyphenyl)propanoate + H(+)"}
{"X":13792,"RHEA_ID":10362,"compounds":"3-(2-hydroxyphenyl)propanoate + H(+) => 3,4-dihydrocoumarin + H2O"}
{"X":13793,"RHEA_ID":40728,"compounds":"1-hexadecanoylglycerone 3-phosphate + a long-chain fatty acid => a 1-acylglycerone 3-phosphate + hexadecanoate"}
{"X":13794,"RHEA_ID":10364,"DIRECTION":"UN","MASTER_ID":10364,"ec":"2.3.3.4","metacyc":"DECYLHOMOCITRATE-SYNTHASE-RXN","compounds":"2-oxoglutarate + dodecanoyl-CoA + H2O = (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H(+)"}
{"X":13795,"RHEA_ID":10365,"compounds":"2-oxoglutarate + dodecanoyl-CoA + H2O => (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H(+)"}
{"X":13796,"RHEA_ID":10366,"compounds":"(3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H(+) => 2-oxoglutarate + dodecanoyl-CoA + H2O"}
{"X":13797,"RHEA_ID":40732,"DIRECTION":"LR","MASTER_ID":40731,"metacyc":"RXN-14616","compounds":"(20S)-ginsenoside Rg3 + 2 H2O => (20S)-protopanaxadiol + 2 D-glucose"}
{"X":13798,"RHEA_ID":10368,"DIRECTION":"UN","MASTER_ID":10368,"ec":"2.6.1.59","compounds":"2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-galactose = dTDP-4-dehydro-6-deoxy-D-galactose + L-glutamate"}
{"X":13799,"RHEA_ID":10369,"compounds":"2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-galactose => dTDP-4-dehydro-6-deoxy-D-galactose + L-glutamate"}
{"X":13800,"RHEA_ID":10370,"compounds":"dTDP-4-dehydro-6-deoxy-D-galactose + L-glutamate => 2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-galactose"}
{"X":13801,"RHEA_ID":40736,"DIRECTION":"LR","MASTER_ID":40735,"metacyc":"RXN-14618","compounds":"(20S)-ginsenoside Rb1 + 2 H2O => 2 D-glucose + gypenoside LXXV"}
{"X":13802,"RHEA_ID":10372,"DIRECTION":"UN","MASTER_ID":10372,"ec":"1.2.1.58","compounds":"CoA + NAD(+) + phenylglyoxylate = benzoyl-CoA + CO2 + NADH"}
{"X":13803,"RHEA_ID":10373,"compounds":"CoA + NAD(+) + phenylglyoxylate => benzoyl-CoA + CO2 + NADH"}
{"X":13804,"RHEA_ID":10374,"compounds":"benzoyl-CoA + CO2 + NADH => CoA + NAD(+) + phenylglyoxylate"}
{"X":13805,"RHEA_ID":20216,"compounds":"[glycine-cleavage complex H protein]-N(6)-octanoyl-L-lysine + [lipoyl-carrier protein]-L-lysine <=> [glycine-cleavage complex H protein]-L-lysine + [lipoyl-carrier protein]-N(6)-octanoyl-L-lysine"}
{"X":13806,"RHEA_ID":10376,"DIRECTION":"UN","MASTER_ID":10376,"ec":"7.2.2.9","compounds":"ATP + Cu(2+)(in) + H2O = ADP + Cu(2+)(out) + H(+) + phosphate"}
{"X":13807,"RHEA_ID":10377,"DIRECTION":"LR","MASTER_ID":10376,"ecocyc":"3.6.3.4-RXN","metacyc":"3.6.3.4-RXN","compounds":"ATP + Cu(2+)(in) + H2O => ADP + Cu(2+)(out) + H(+) + phosphate"}
{"X":13808,"RHEA_ID":10378,"compounds":"ADP + Cu(2+)(out) + H(+) + phosphate => ATP + Cu(2+)(in) + H2O"}
{"X":13809,"RHEA_ID":10379,"compounds":"ATP + Cu(2+)(in) + H2O <=> ADP + Cu(2+)(out) + H(+) + phosphate"}
{"X":13810,"RHEA_ID":10380,"DIRECTION":"UN","MASTER_ID":10380,"ec":"2.4.2.10","compounds":"diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate"}
{"X":13811,"RHEA_ID":10381,"compounds":"diphosphate + orotidine 5'-phosphate => 5-phospho-alpha-D-ribose 1-diphosphate + orotate"}
{"X":13812,"RHEA_ID":10382,"DIRECTION":"RL","MASTER_ID":10380,"reactome":"R-HSA-73567.2","compounds":"5-phospho-alpha-D-ribose 1-diphosphate + orotate => diphosphate + orotidine 5'-phosphate"}
{"X":13813,"RHEA_ID":40748,"compounds":"2-oxoglutarate + L-lysine + O2 => (3S)-3-hydroxy-L-lysine + CO2 + succinate"}
{"X":13814,"RHEA_ID":10388,"DIRECTION":"UN","MASTER_ID":10388,"ec":"4.1.1.32","compounds":"GTP + oxaloacetate = CO2 + GDP + phosphoenolpyruvate"}
{"X":13815,"RHEA_ID":10389,"DIRECTION":"LR","MASTER_ID":10388,"reactome":"R-HSA-372819.1","compounds":"GTP + oxaloacetate => CO2 + GDP + phosphoenolpyruvate"}
{"X":13816,"RHEA_ID":10389,"DIRECTION":"LR","MASTER_ID":10388,"reactome":"R-HSA-70241.2","compounds":"GTP + oxaloacetate => CO2 + GDP + phosphoenolpyruvate"}
{"X":13817,"RHEA_ID":10390,"compounds":"CO2 + GDP + phosphoenolpyruvate => GTP + oxaloacetate"}
{"X":13818,"RHEA_ID":20229,"DIRECTION":"UN","MASTER_ID":20229,"ec":"2.7.7.58","compounds":"2,3-dihydroxybenzoate + ATP + H(+) = 2,3-dihydroxybenzoyl-5'-AMP + diphosphate"}
{"X":13819,"RHEA_ID":10392,"DIRECTION":"UN","MASTER_ID":10392,"ec":"1.1.1.195","compounds":"(E)-cinnamyl alcohol + NADP(+) = (E)-cinnamaldehyde + H(+) + NADPH"}
{"X":13820,"RHEA_ID":10393,"compounds":"(E)-cinnamyl alcohol + NADP(+) => (E)-cinnamaldehyde + H(+) + NADPH"}
{"X":13821,"RHEA_ID":10394,"compounds":"(E)-cinnamaldehyde + H(+) + NADPH => (E)-cinnamyl alcohol + NADP(+)"}
{"X":13822,"RHEA_ID":20233,"DIRECTION":"UN","MASTER_ID":20233,"ec":"1.1.1.201","compounds":"a 7beta-hydroxysteroid + NADP(+) = a 7-oxosteroid + H(+) + NADPH"}
{"X":13823,"RHEA_ID":10396,"DIRECTION":"UN","MASTER_ID":10396,"ec":"1.4.1.5","compounds":"an L-alpha-amino acid + H2O + NAD(+) = a 2-oxocarboxylate + H(+) + NADH + NH4(+)"}
{"X":13824,"RHEA_ID":10397,"DIRECTION":"LR","MASTER_ID":10396,"metacyc":"L-AMINO-ACID-DEHYDROGENASE-RXN","compounds":"an L-alpha-amino acid + H2O + NAD(+) => a 2-oxocarboxylate + H(+) + NADH + NH4(+)"}
{"X":13825,"RHEA_ID":10398,"compounds":"a 2-oxocarboxylate + H(+) + NADH + NH4(+) => an L-alpha-amino acid + H2O + NAD(+)"}
{"X":13826,"RHEA_ID":10400,"DIRECTION":"UN","MASTER_ID":10400,"ec":"2.6.1.15","compounds":"L-glutamine + pyruvate = 2-oxoglutaramate + L-alanine"}
{"X":13827,"RHEA_ID":10401,"DIRECTION":"LR","MASTER_ID":10400,"reactome":"R-HSA-893616.2","compounds":"L-glutamine + pyruvate => 2-oxoglutaramate + L-alanine"}
{"X":13828,"RHEA_ID":10402,"compounds":"2-oxoglutaramate + L-alanine => L-glutamine + pyruvate"}
{"X":13829,"RHEA_ID":20241,"DIRECTION":"UN","MASTER_ID":20241,"ec":"2.1.1.7","compounds":"nicotinate + S-adenosyl-L-methionine = N-methylnicotinate + S-adenosyl-L-homocysteine"}
{"X":13830,"RHEA_ID":10408,"DIRECTION":"UN","MASTER_ID":10408,"ec":"2.3.1.176","metacyc":"2.3.1.154-RXN","compounds":"4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = 3-oxopristanoyl-CoA + CoA"}
{"X":13831,"RHEA_ID":10409,"compounds":"4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA => 3-oxopristanoyl-CoA + CoA"}
{"X":13832,"RHEA_ID":10410,"DIRECTION":"RL","MASTER_ID":10408,"reactome":"R-HSA-390224.1","compounds":"3-oxopristanoyl-CoA + CoA => 4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA"}
{"X":13833,"RHEA_ID":20245,"DIRECTION":"UN","MASTER_ID":20245,"ec":"2.7.7.47","compounds":"ATP + streptomycin = 3''-adenylylstreptomycin + diphosphate"}
{"X":13834,"RHEA_ID":10412,"DIRECTION":"UN","MASTER_ID":10412,"ec":"3.6.1.53","compounds":"ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate + 2 H(+)"}
{"X":13835,"RHEA_ID":10412,"DIRECTION":"UN","MASTER_ID":10412,"ec":"3.6.1.13","compounds":"ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate + 2 H(+)"}
{"X":13836,"RHEA_ID":10413,"DIRECTION":"LR","MASTER_ID":10412,"ecocyc":"RXN0-1441","metacyc":"RXN0-1441","compounds":"ADP-D-ribose + H2O => AMP + D-ribose 5-phosphate + 2 H(+)"}
{"X":13837,"RHEA_ID":10414,"compounds":"AMP + D-ribose 5-phosphate + 2 H(+) => ADP-D-ribose + H2O"}
{"X":13838,"RHEA_ID":20250,"DIRECTION":"LR","MASTER_ID":20249,"macie":"M0213","compounds":"L-alanine => D-alanine"}
{"X":13839,"RHEA_ID":10416,"DIRECTION":"UN","MASTER_ID":10416,"ec":"4.1.99.11","compounds":"fumarate + toluene = 2-benzylsuccinate"}
{"X":13840,"RHEA_ID":10417,"DIRECTION":"LR","MASTER_ID":10416,"metacyc":"RXN-863","compounds":"fumarate + toluene => 2-benzylsuccinate"}
{"X":13841,"RHEA_ID":10418,"compounds":"2-benzylsuccinate => fumarate + toluene"}
{"X":13842,"RHEA_ID":20254,"compounds":"(2R,3S)-2,3-dimethylmalate => dimethylmaleate + H2O"}
{"X":13843,"RHEA_ID":10420,"DIRECTION":"UN","MASTER_ID":10420,"ec":"2.6.1.77","compounds":"pyruvate + taurine = L-alanine + sulfoacetaldehyde"}
{"X":13844,"RHEA_ID":10421,"compounds":"pyruvate + taurine => L-alanine + sulfoacetaldehyde"}
{"X":13845,"RHEA_ID":10422,"compounds":"L-alanine + sulfoacetaldehyde => pyruvate + taurine"}
{"X":13846,"RHEA_ID":20258,"compounds":"3-methyloxindole + NADP(+) => 3-methyleneoxindole + H(+) + NADPH"}
{"X":13847,"RHEA_ID":10424,"DIRECTION":"UN","MASTER_ID":10424,"ec":"3.5.1.32","compounds":"H2O + N-benzoylglycine = benzoate + glycine"}
{"X":13848,"RHEA_ID":10425,"DIRECTION":"LR","MASTER_ID":10424,"metacyc":"HIPPURATE-HYDROLASE-RXN","compounds":"H2O + N-benzoylglycine => benzoate + glycine"}
{"X":13849,"RHEA_ID":10426,"compounds":"benzoate + glycine => H2O + N-benzoylglycine"}
{"X":13850,"RHEA_ID":20266,"DIRECTION":"LR","MASTER_ID":20265,"metacyc":"1.14.11.28-RXN","compounds":"2-oxoglutarate + L-proline + O2 => cis-3-hydroxy-L-proline + CO2 + succinate"}
{"X":13851,"RHEA_ID":10428,"DIRECTION":"UN","MASTER_ID":10428,"ec":"1.13.11.31","compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate"}
{"X":13852,"RHEA_ID":10429,"DIRECTION":"LR","MASTER_ID":10428,"metacyc":"ARACHIDONATE-12-LIPOXYGENASE-RXN","reactome":"R-HSA-2161964.2","compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate"}
{"X":13853,"RHEA_ID":10430,"compounds":"(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2"}
{"X":13854,"RHEA_ID":20270,"compounds":"4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate => 2 5-dehydro-4-deoxy-D-glucuronate"}
{"X":13855,"RHEA_ID":10432,"DIRECTION":"UN","MASTER_ID":10432,"ec":"3.5.1.29","compounds":"2-(acetamidomethylene)succinate + H(+) + 2 H2O = acetate + CO2 + NH4(+) + succinate semialdehyde"}
{"X":13856,"RHEA_ID":10433,"DIRECTION":"LR","MASTER_ID":10432,"metacyc":"3.5.1.29-RXN","compounds":"2-(acetamidomethylene)succinate + H(+) + 2 H2O => acetate + CO2 + NH4(+) + succinate semialdehyde"}
{"X":13857,"RHEA_ID":10434,"compounds":"acetate + CO2 + NH4(+) + succinate semialdehyde => 2-(acetamidomethylene)succinate + H(+) + 2 H2O"}
{"X":13858,"RHEA_ID":20274,"DIRECTION":"LR","MASTER_ID":20273,"metacyc":"PHENYLALANINE-4-MONOOXYGENASE-RXN","compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 => (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine"}
{"X":13859,"RHEA_ID":10436,"DIRECTION":"UN","MASTER_ID":10436,"ec":"4.2.1.106","compounds":"7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O"}
{"X":13860,"RHEA_ID":10437,"DIRECTION":"LR","MASTER_ID":10436,"metacyc":"BA7DEHYDRA-RXN","compounds":"7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA => 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O"}
{"X":13861,"RHEA_ID":10438,"compounds":"12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O => 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA"}
{"X":13862,"RHEA_ID":10440,"DIRECTION":"UN","MASTER_ID":10440,"ec":"3.1.1.17","compounds":"D-glucono-1,5-lactone + H2O = D-gluconate + H(+)"}
{"X":13863,"RHEA_ID":10441,"DIRECTION":"LR","MASTER_ID":10440,"ecocyc":"GLUCONOLACT-RXN","metacyc":"GLUCONOLACT-RXN","compounds":"D-glucono-1,5-lactone + H2O => D-gluconate + H(+)"}
{"X":13864,"RHEA_ID":10442,"compounds":"D-gluconate + H(+) => D-glucono-1,5-lactone + H2O"}
{"X":13865,"RHEA_ID":20282,"DIRECTION":"LR","MASTER_ID":20281,"metacyc":"RXN-4606","compounds":"3'-phosphoadenylyl sulfate + desulfoglucotropeolin => adenosine 3',5'-bisphosphate + glucotropeolin + H(+)"}
{"X":13866,"RHEA_ID":10444,"DIRECTION":"UN","MASTER_ID":10444,"ec":"2.1.1.291","compounds":"(S)-reticuline + S-adenosyl-L-methionine = (S)-laudanine + H(+) + S-adenosyl-L-homocysteine"}
{"X":13867,"RHEA_ID":10445,"DIRECTION":"LR","MASTER_ID":10444,"metacyc":"RXN-8700","compounds":"(S)-reticuline + S-adenosyl-L-methionine => (S)-laudanine + H(+) + S-adenosyl-L-homocysteine"}
{"X":13868,"RHEA_ID":10446,"compounds":"(S)-laudanine + H(+) + S-adenosyl-L-homocysteine => (S)-reticuline + S-adenosyl-L-methionine"}
{"X":13869,"RHEA_ID":20286,"compounds":"beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + phosphate => alpha-D-galactose 1-phosphate + N-acetyl-D-glucosamine"}
{"X":13870,"RHEA_ID":10448,"DIRECTION":"UN","MASTER_ID":10448,"ec":"1.14.20.5","compounds":"2-oxoglutarate + a flavanone + O2 = a flavone + CO2 + H2O + succinate"}
{"X":13871,"RHEA_ID":10449,"DIRECTION":"LR","MASTER_ID":10448,"metacyc":"RXN-8000","compounds":"2-oxoglutarate + a flavanone + O2 => a flavone + CO2 + H2O + succinate"}
{"X":13872,"RHEA_ID":10450,"compounds":"a flavone + CO2 + H2O + succinate => 2-oxoglutarate + a flavanone + O2"}
{"X":13873,"RHEA_ID":20290,"DIRECTION":"LR","MASTER_ID":20289,"reactome":"R-HSA-390304.1","compounds":"acetyl-CoA + H2O => acetate + CoA + H(+)"}
{"X":13874,"RHEA_ID":10452,"compounds":"2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + O2 + reduced [NADPH--hemoprotein reductase] = (R)-dihydrocamalexate + 2 H(+) + 2 H2O + hydrogen cyanide + oxidized [NADPH--hemoprotein reductase]"}
{"X":13875,"RHEA_ID":10453,"DIRECTION":"LR","MASTER_ID":10452,"metacyc":"RXN-11666","compounds":"2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + O2 + reduced [NADPH--hemoprotein reductase] => (R)-dihydrocamalexate + 2 H(+) + 2 H2O + hydrogen cyanide + oxidized [NADPH--hemoprotein reductase]"}
{"X":13876,"RHEA_ID":10454,"compounds":"(R)-dihydrocamalexate + 2 H(+) + 2 H2O + hydrogen cyanide + oxidized [NADPH--hemoprotein reductase] => 2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":13877,"RHEA_ID":20294,"compounds":"3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD(+) => 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H(+) + NADH"}
{"X":13878,"RHEA_ID":10456,"DIRECTION":"UN","MASTER_ID":10456,"ec":"2.3.1.79","compounds":"acetyl-CoA + D-maltose = 1-O-acetylmaltose + CoA"}
{"X":13879,"RHEA_ID":10457,"compounds":"acetyl-CoA + D-maltose => 1-O-acetylmaltose + CoA"}
{"X":13880,"RHEA_ID":10458,"compounds":"1-O-acetylmaltose + CoA => acetyl-CoA + D-maltose"}
{"X":13881,"RHEA_ID":20298,"compounds":"an anilide + H2O => a carboxylate + aniline + H(+)"}
{"X":13882,"RHEA_ID":10460,"DIRECTION":"UN","MASTER_ID":10460,"ec":"5.3.3.9","metacyc":"PROSTAGLANDIN-A1-DELTA-ISOMERASE-RXN","compounds":"prostaglandin A1 = prostaglandin C1"}
{"X":13883,"RHEA_ID":10461,"compounds":"prostaglandin A1 => prostaglandin C1"}
{"X":13884,"RHEA_ID":10462,"compounds":"prostaglandin C1 => prostaglandin A1"}
{"X":13885,"RHEA_ID":20302,"DIRECTION":"LR","MASTER_ID":20301,"ecocyc":"ARGININE--TRNA-LIGASE-RXN","metacyc":"ARGININE--TRNA-LIGASE-RXN","compounds":"ATP + L-arginine + tRNA(Arg) => AMP + diphosphate + L-arginyl-tRNA(Arg)"}
{"X":13886,"RHEA_ID":10464,"DIRECTION":"UN","MASTER_ID":10464,"ec":"3.5.1.41","compounds":"[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = n acetate + chitosan"}
{"X":13887,"RHEA_ID":10465,"DIRECTION":"LR","MASTER_ID":10464,"metacyc":"CHITIN-DEACETYLASE-RXN","compounds":"[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O => n acetate + chitosan"}
{"X":13888,"RHEA_ID":10466,"compounds":"n acetate + chitosan => [(1->4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O"}
{"X":13889,"RHEA_ID":10468,"DIRECTION":"UN","MASTER_ID":10468,"ec":"4.1.2.9","compounds":"D-xylulose 5-phosphate + phosphate = acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O"}
{"X":13890,"RHEA_ID":10469,"DIRECTION":"LR","MASTER_ID":10468,"metacyc":"PHOSPHOKETOLASE-RXN","compounds":"D-xylulose 5-phosphate + phosphate => acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O"}
{"X":13891,"RHEA_ID":10470,"compounds":"acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O => D-xylulose 5-phosphate + phosphate"}
{"X":13892,"RHEA_ID":20309,"DIRECTION":"UN","MASTER_ID":20309,"ec":"1.11.1.21","compounds":"2 H2O2 = 2 H2O + O2"}
{"X":13893,"RHEA_ID":10472,"DIRECTION":"UN","MASTER_ID":10472,"ec":"4.1.3.32","compounds":"(2R,3S)-2,3-dimethylmalate = propanoate + pyruvate"}
{"X":13894,"RHEA_ID":10473,"DIRECTION":"LR","MASTER_ID":10472,"metacyc":"23-DIMETHYLMALATE-LYASE-RXN","compounds":"(2R,3S)-2,3-dimethylmalate => propanoate + pyruvate"}
{"X":13895,"RHEA_ID":10474,"compounds":"propanoate + pyruvate => (2R,3S)-2,3-dimethylmalate"}
{"X":13896,"RHEA_ID":10480,"DIRECTION":"UN","MASTER_ID":10480,"ec":"2.6.1.23","compounds":"2-oxoglutarate + 4-hydroxy-L-glutamate = 4-hydroxy-2-oxoglutarate + L-glutamate"}
{"X":13897,"RHEA_ID":10481,"compounds":"2-oxoglutarate + 4-hydroxy-L-glutamate => 4-hydroxy-2-oxoglutarate + L-glutamate"}
{"X":13898,"RHEA_ID":10482,"compounds":"4-hydroxy-2-oxoglutarate + L-glutamate => 2-oxoglutarate + 4-hydroxy-L-glutamate"}
{"X":13899,"RHEA_ID":30872,"DIRECTION":"LR","MASTER_ID":30871,"metacyc":"RXN-14223","compounds":"2-deoxy-D-ribose + ATP => 2-deoxy-D-ribose 5-phosphate + ADP + H(+)"}
{"X":13900,"RHEA_ID":10484,"DIRECTION":"UN","MASTER_ID":10484,"ec":"3.5.1.71","metacyc":"N-FERULOYLGLYCINE-DEACYLASE-RXN","compounds":"H2O + N-feruloylglycine = glycine + trans-ferulate"}
{"X":13901,"RHEA_ID":10485,"compounds":"H2O + N-feruloylglycine => glycine + trans-ferulate"}
{"X":13902,"RHEA_ID":10486,"compounds":"glycine + trans-ferulate => H2O + N-feruloylglycine"}
{"X":13903,"RHEA_ID":20318,"compounds":"L-proline + NADP(+) => 1-pyrroline-2-carboxylate + H(+) + NADPH"}
{"X":13904,"RHEA_ID":10488,"DIRECTION":"UN","MASTER_ID":10488,"ec":"6.3.3.2","compounds":"5-formyltetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + phosphate"}
{"X":13905,"RHEA_ID":10489,"DIRECTION":"LR","MASTER_ID":10488,"ecocyc":"5-FORMYL-THF-CYCLO-LIGASE-RXN","metacyc":"5-FORMYL-THF-CYCLO-LIGASE-RXN","compounds":"5-formyltetrahydrofolate + ATP => 5,10-methenyltetrahydrofolate + ADP + phosphate"}
{"X":13906,"RHEA_ID":10490,"compounds":"5,10-methenyltetrahydrofolate + ADP + phosphate => 5-formyltetrahydrofolate + ATP"}
{"X":13907,"RHEA_ID":20321,"DIRECTION":"UN","MASTER_ID":20321,"ec":"1.5.1.49","compounds":"L-proline + NAD(+) = 1-pyrroline-2-carboxylate + H(+) + NADH"}
{"X":13908,"RHEA_ID":10492,"DIRECTION":"UN","MASTER_ID":10492,"ec":"3.1.3.75","compounds":"H2O + phosphocholine = choline + phosphate"}
{"X":13909,"RHEA_ID":10493,"DIRECTION":"LR","MASTER_ID":10492,"ecocyc":"RXN-5647","metacyc":"RXN-5647","compounds":"H2O + phosphocholine => choline + phosphate"}
{"X":13910,"RHEA_ID":10494,"compounds":"choline + phosphate => H2O + phosphocholine"}
{"X":13911,"RHEA_ID":20325,"DIRECTION":"UN","MASTER_ID":20325,"ec":"2.3.1.56","metacyc":"2.3.1.56-RXN","compounds":"N-hydroxy-4-acetylaminobiphenyl = N-acetoxy-4-aminobiphenyl"}
{"X":13912,"RHEA_ID":10496,"compounds":"L-arginyl-[myelin basic protein] + S-adenosyl-L-methionine = H(+) + N(omega)-methyl-L-arginyl-[myelin basic protein] + S-adenosyl-L-homocysteine"}
{"X":13913,"RHEA_ID":10497,"DIRECTION":"LR","MASTER_ID":10496,"metacyc":"2.1.1.126-RXN","compounds":"L-arginyl-[myelin basic protein] + S-adenosyl-L-methionine => H(+) + N(omega)-methyl-L-arginyl-[myelin basic protein] + S-adenosyl-L-homocysteine"}
{"X":13914,"RHEA_ID":10498,"compounds":"H(+) + N(omega)-methyl-L-arginyl-[myelin basic protein] + S-adenosyl-L-homocysteine => L-arginyl-[myelin basic protein] + S-adenosyl-L-methionine"}
{"X":13915,"RHEA_ID":20329,"DIRECTION":"UN","MASTER_ID":20329,"ec":"2.7.11.29","metacyc":"2.7.11.29-RXN","compounds":"ATP + L-seryl-[low-density-lipoprotein receptor] = ADP + H(+) + O-phospho-L-seryl-[low-density-lipoprotein receptor]"}
{"X":13916,"RHEA_ID":10500,"DIRECTION":"UN","MASTER_ID":10500,"ec":"2.3.3.7","compounds":"butanoyl-CoA + glyoxylate + H2O = 3-ethylmalate + CoA + H(+)"}
{"X":13917,"RHEA_ID":10501,"compounds":"butanoyl-CoA + glyoxylate + H2O => 3-ethylmalate + CoA + H(+)"}
{"X":13918,"RHEA_ID":10502,"compounds":"3-ethylmalate + CoA + H(+) => butanoyl-CoA + glyoxylate + H2O"}
{"X":13919,"RHEA_ID":20333,"DIRECTION":"UN","MASTER_ID":20333,"ec":"2.7.11.27","compounds":"[acetyl-CoA carboxylase]-L-serine + ATP = [acetyl-CoA carboxylase]-O-phospho-L-serine + ADP + H(+)"}
{"X":13920,"RHEA_ID":10504,"compounds":"7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH + O2 = 7alpha,12alpha-dihydroxycholest-4-en-3-one + H2O + NADP(+)"}
{"X":13921,"RHEA_ID":10505,"compounds":"7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH + O2 => 7alpha,12alpha-dihydroxycholest-4-en-3-one + H2O + NADP(+)"}
{"X":13922,"RHEA_ID":10506,"compounds":"7alpha,12alpha-dihydroxycholest-4-en-3-one + H2O + NADP(+) => 7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH + O2"}
{"X":13923,"RHEA_ID":10507,"compounds":"7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH + O2 <=> 7alpha,12alpha-dihydroxycholest-4-en-3-one + H2O + NADP(+)"}
{"X":13924,"RHEA_ID":10508,"DIRECTION":"UN","MASTER_ID":10508,"ec":"2.2.1.1","compounds":"D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate"}
{"X":13925,"RHEA_ID":10509,"DIRECTION":"LR","MASTER_ID":10508,"macie":"M0219","compounds":"D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate => aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate"}
{"X":13926,"RHEA_ID":10510,"compounds":"aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate => D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate"}
{"X":13927,"RHEA_ID":20341,"DIRECTION":"UN","MASTER_ID":20341,"ec":"2.4.1.96","metacyc":"2.4.1.96-RXN","compounds":"sn-glycerol 3-phosphate + UDP-alpha-D-galactose = 1-O-alpha-D-galactosyl-sn-glycerol 3-phosphate + H(+) + UDP"}
{"X":13928,"RHEA_ID":10516,"DIRECTION":"UN","MASTER_ID":10516,"ec":"1.1.1.166","metacyc":"1.1.1.166-RXN","compounds":"(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD(+) = (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + H(+) + NADH"}
{"X":13929,"RHEA_ID":10517,"compounds":"(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD(+) => (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + H(+) + NADH"}
{"X":13930,"RHEA_ID":10518,"compounds":"(1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + H(+) + NADH => (1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD(+)"}
{"X":13931,"RHEA_ID":20345,"DIRECTION":"UN","MASTER_ID":20345,"ec":"1.8.1.9","compounds":"[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH"}
{"X":13932,"RHEA_ID":10520,"DIRECTION":"UN","MASTER_ID":10520,"ec":"2.4.1.241","compounds":"a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose = 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP"}
{"X":13933,"RHEA_ID":10521,"DIRECTION":"LR","MASTER_ID":10520,"metacyc":"RXN-1225","compounds":"a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose => 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP"}
{"X":13934,"RHEA_ID":10522,"compounds":"1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose"}
{"X":13935,"RHEA_ID":20349,"DIRECTION":"UN","MASTER_ID":20349,"ec":"1.14.13.243","compounds":"H(+) + NADH + O2 + toluene = 2-hydroxytoluene + H2O + NAD(+)"}
{"X":13936,"RHEA_ID":10524,"DIRECTION":"UN","MASTER_ID":10524,"ec":"4.1.1.71","compounds":"2-oxoglutarate + H(+) = CO2 + succinate semialdehyde"}
{"X":13937,"RHEA_ID":10525,"DIRECTION":"LR","MASTER_ID":10524,"metacyc":"RXN-7774","compounds":"2-oxoglutarate + H(+) => CO2 + succinate semialdehyde"}
{"X":13938,"RHEA_ID":10526,"compounds":"CO2 + succinate semialdehyde => 2-oxoglutarate + H(+)"}
{"X":13939,"RHEA_ID":20353,"DIRECTION":"UN","MASTER_ID":20353,"ec":"1.21.99.5","compounds":"A + chloride + H(+) + trichloroethene = AH2 + tetrachloroethene"}
{"X":13940,"RHEA_ID":10528,"DIRECTION":"UN","MASTER_ID":10528,"ec":"1.14.14.100","compounds":"dihydrosanguinarine + O2 + reduced [NADPH--hemoprotein reductase] = 10-hydroxydihydrosanguinarine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":13941,"RHEA_ID":10529,"DIRECTION":"LR","MASTER_ID":10528,"metacyc":"1.14.13.56-RXN","compounds":"dihydrosanguinarine + O2 + reduced [NADPH--hemoprotein reductase] => 10-hydroxydihydrosanguinarine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":13942,"RHEA_ID":10530,"compounds":"10-hydroxydihydrosanguinarine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dihydrosanguinarine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":13943,"RHEA_ID":20357,"DIRECTION":"UN","MASTER_ID":20357,"ec":"1.14.12.19","compounds":"3-phenylpropanoate + H(+) + NADH + O2 = 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+)"}
{"X":13944,"RHEA_ID":10532,"DIRECTION":"UN","MASTER_ID":10532,"ec":"4.2.1.20","compounds":"(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan"}
{"X":13945,"RHEA_ID":10533,"DIRECTION":"LR","MASTER_ID":10532,"ecocyc":"TRYPSYN-RXN","metacyc":"TRYPSYN-RXN","compounds":"(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine => D-glyceraldehyde 3-phosphate + H2O + L-tryptophan"}
{"X":13946,"RHEA_ID":10534,"compounds":"D-glyceraldehyde 3-phosphate + H2O + L-tryptophan => (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine"}
{"X":13947,"RHEA_ID":20361,"compounds":"4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":13948,"RHEA_ID":10536,"DIRECTION":"UN","MASTER_ID":10536,"ec":"3.1.6.10","compounds":"4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 6-sulfate + H2O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate"}
{"X":13949,"RHEA_ID":10537,"DIRECTION":"LR","MASTER_ID":10536,"metacyc":"CHONDRO-6-SULFATASE-RXN","compounds":"4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 6-sulfate + H2O => 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate"}
{"X":13950,"RHEA_ID":10538,"compounds":"4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate => 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 6-sulfate + H2O"}
{"X":13951,"RHEA_ID":20365,"DIRECTION":"UN","MASTER_ID":20365,"ec":"2.1.1.103","compounds":"phosphoethanolamine + S-adenosyl-L-methionine = H(+) + N-methylethanolamine phosphate + S-adenosyl-L-homocysteine"}
{"X":13952,"RHEA_ID":10540,"DIRECTION":"UN","MASTER_ID":10540,"ec":"4.1.2.25","compounds":"7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde"}
{"X":13953,"RHEA_ID":10541,"DIRECTION":"LR","MASTER_ID":10540,"ecocyc":"H2NEOPTERINALDOL-RXN","metacyc":"H2NEOPTERINALDOL-RXN","compounds":"7,8-dihydroneopterin => 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde"}
{"X":13954,"RHEA_ID":10542,"compounds":"6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde => 7,8-dihydroneopterin"}
{"X":13955,"RHEA_ID":20369,"compounds":"betaine aldehyde + H2O + O2 = betaine + H(+) + H2O2"}
{"X":13956,"RHEA_ID":10548,"DIRECTION":"UN","MASTER_ID":10548,"ec":"1.13.12.1","compounds":"L-arginine + O2 = 4-guanidinobutanamide + CO2 + H2O"}
{"X":13957,"RHEA_ID":10549,"DIRECTION":"LR","MASTER_ID":10548,"metacyc":"ARGININE-2-MONOOXYGENASE-RXN","compounds":"L-arginine + O2 => 4-guanidinobutanamide + CO2 + H2O"}
{"X":13958,"RHEA_ID":10550,"compounds":"4-guanidinobutanamide + CO2 + H2O => L-arginine + O2"}
{"X":13959,"RHEA_ID":20373,"DIRECTION":"UN","MASTER_ID":20373,"ec":"6.2.1.17","compounds":"ATP + CoA + propanoate = AMP + diphosphate + propanoyl-CoA"}
{"X":13960,"RHEA_ID":10552,"DIRECTION":"UN","MASTER_ID":10552,"ec":"1.1.3.10","compounds":"D-glucose + O2 = 2-dehydro-D-glucose + H2O2"}
{"X":13961,"RHEA_ID":10553,"DIRECTION":"LR","MASTER_ID":10552,"metacyc":"PYRANOSE-OXIDASE-RXN","compounds":"D-glucose + O2 => 2-dehydro-D-glucose + H2O2"}
{"X":13962,"RHEA_ID":10554,"compounds":"2-dehydro-D-glucose + H2O2 => D-glucose + O2"}
{"X":13963,"RHEA_ID":20377,"DIRECTION":"UN","MASTER_ID":20377,"ec":"1.1.1.209","compounds":"3alpha-hydroxy-5alpha-androstan-17-one + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH"}
{"X":13964,"RHEA_ID":10556,"DIRECTION":"UN","MASTER_ID":10556,"ec":"2.5.1.66","compounds":"D-glyceraldehyde 3-phosphate + L-arginine = H(+) + N(2)-(2-carboxyethyl)-L-arginine + phosphate"}
{"X":13965,"RHEA_ID":10557,"DIRECTION":"LR","MASTER_ID":10556,"metacyc":"2.5.1.66-RXN","compounds":"D-glyceraldehyde 3-phosphate + L-arginine => H(+) + N(2)-(2-carboxyethyl)-L-arginine + phosphate"}
{"X":13966,"RHEA_ID":10558,"compounds":"H(+) + N(2)-(2-carboxyethyl)-L-arginine + phosphate => D-glyceraldehyde 3-phosphate + L-arginine"}
{"X":13967,"RHEA_ID":20381,"DIRECTION":"UN","MASTER_ID":20381,"ec":"1.1.1.209","compounds":"3alpha-hydroxy-5alpha-androstan-17-one + NAD(+) = 5alpha-androstan-3,17-dione + H(+) + NADH"}
{"X":13968,"RHEA_ID":10560,"DIRECTION":"UN","MASTER_ID":10560,"ec":"3.5.4.22","compounds":"4-hydroxy-1-pyrroline-2-carboxylate + H(+) + H2O = 2,5-dioxopentanoate + NH4(+)"}
{"X":13969,"RHEA_ID":10561,"DIRECTION":"LR","MASTER_ID":10560,"metacyc":"3.5.4.22-RXN","compounds":"4-hydroxy-1-pyrroline-2-carboxylate + H(+) + H2O => 2,5-dioxopentanoate + NH4(+)"}
{"X":13970,"RHEA_ID":10562,"compounds":"2,5-dioxopentanoate + NH4(+) => 4-hydroxy-1-pyrroline-2-carboxylate + H(+) + H2O"}
{"X":13971,"RHEA_ID":20385,"DIRECTION":"UN","MASTER_ID":20385,"ec":"1.14.13.19","compounds":"(2R,3R)-dihydroquercetin + H(+) + NADH + O2 = (2R,3R)-2,3-dihydrogossypetin + H2O + NAD(+)"}
{"X":13972,"RHEA_ID":10564,"DIRECTION":"UN","MASTER_ID":10564,"ec":"3.1.1.44","compounds":"H2O + oxaloacetate 4-methyl ester = H(+) + methanol + oxaloacetate"}
{"X":13973,"RHEA_ID":10565,"DIRECTION":"LR","MASTER_ID":10564,"metacyc":"4-METHYLOXALOACETATE-ESTERASE-RXN","compounds":"H2O + oxaloacetate 4-methyl ester => H(+) + methanol + oxaloacetate"}
{"X":13974,"RHEA_ID":10566,"compounds":"H(+) + methanol + oxaloacetate => H2O + oxaloacetate 4-methyl ester"}
{"X":13975,"RHEA_ID":20389,"DIRECTION":"UN","MASTER_ID":20389,"ec":"1.14.13.19","compounds":"(2R,3R)-dihydroquercetin + H(+) + NADPH + O2 = (2R,3R)-2,3-dihydrogossypetin + H2O + NADP(+)"}
{"X":13976,"RHEA_ID":10568,"DIRECTION":"UN","MASTER_ID":10568,"ec":"2.4.1.189","compounds":"luteolin + UDP-alpha-D-glucuronate = H(+) + luteolin 7-O-beta-D-glucuronide + UDP"}
{"X":13977,"RHEA_ID":10569,"DIRECTION":"LR","MASTER_ID":10568,"metacyc":"LUTEOLIN-7-O-GLUCORONOSYLTRANSFERASE-RXN","compounds":"luteolin + UDP-alpha-D-glucuronate => H(+) + luteolin 7-O-beta-D-glucuronide + UDP"}
{"X":13978,"RHEA_ID":10570,"compounds":"H(+) + luteolin 7-O-beta-D-glucuronide + UDP => luteolin + UDP-alpha-D-glucuronate"}
{"X":13979,"RHEA_ID":20393,"DIRECTION":"UN","MASTER_ID":20393,"ec":"2.3.1.49","compounds":"holo-[citrate lyase ACP] + S-acetylphosphopantotheine = acetyl-[citrate lyase ACP] + D-pantetheine 4'-phosphate"}
{"X":13980,"RHEA_ID":10572,"DIRECTION":"UN","MASTER_ID":10572,"ec":"5.3.3.3","compounds":"vinylacetyl-CoA = (2E)-butenoyl-CoA"}
{"X":13981,"RHEA_ID":10573,"compounds":"vinylacetyl-CoA => (2E)-butenoyl-CoA"}
{"X":13982,"RHEA_ID":10574,"compounds":"(2E)-butenoyl-CoA => vinylacetyl-CoA"}
{"X":13983,"RHEA_ID":20397,"DIRECTION":"UN","MASTER_ID":20397,"ec":"2.5.1.48","compounds":"L-cysteine + O-succinyl-L-homoserine = H(+) + L,L-cystathionine + succinate"}
{"X":13984,"RHEA_ID":10576,"DIRECTION":"UN","MASTER_ID":10576,"ec":"2.7.7.57","compounds":"CTP + H(+) + N-methylethanolamine phosphate = CDP-N-methylethanolamine + diphosphate"}
{"X":13985,"RHEA_ID":10577,"DIRECTION":"LR","MASTER_ID":10576,"metacyc":"2.7.7.57-RXN","compounds":"CTP + H(+) + N-methylethanolamine phosphate => CDP-N-methylethanolamine + diphosphate"}
{"X":13986,"RHEA_ID":10578,"compounds":"CDP-N-methylethanolamine + diphosphate => CTP + H(+) + N-methylethanolamine phosphate"}
{"X":13987,"RHEA_ID":20401,"DIRECTION":"UN","MASTER_ID":20401,"ec":"3.5.2.6","compounds":"a beta-lactam + H2O = a substituted beta-amino acid"}
{"X":13988,"RHEA_ID":10580,"DIRECTION":"UN","MASTER_ID":10580,"ec":"6.3.2.17","compounds":"(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n + ATP + L-glutamate = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n+1 + ADP + H(+) + phosphate"}
{"X":13989,"RHEA_ID":10581,"DIRECTION":"LR","MASTER_ID":10580,"ecocyc":"FOLYLPOLYGLUTAMATESYNTH-RXN","metacyc":"FOLYLPOLYGLUTAMATESYNTH-RXN","compounds":"(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n + ATP + L-glutamate => (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n+1 + ADP + H(+) + phosphate"}
{"X":13990,"RHEA_ID":10582,"compounds":"(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n+1 + ADP + H(+) + phosphate => (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n + ATP + L-glutamate"}
{"X":13991,"RHEA_ID":20405,"DIRECTION":"UN","MASTER_ID":20405,"ec":"3.5.1.47","compounds":"H2O + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate = (2S,6S)-2,6-diaminoheptanedioate + acetate"}
{"X":13992,"RHEA_ID":10584,"DIRECTION":"UN","MASTER_ID":10584,"ec":"2.3.1.170","compounds":"4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH = 3 CO2 + 4 CoA + H2O + isoliquiritigenin + NADP(+)"}
{"X":13993,"RHEA_ID":10585,"DIRECTION":"LR","MASTER_ID":10584,"metacyc":"RXN-3142","compounds":"4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH => 3 CO2 + 4 CoA + H2O + isoliquiritigenin + NADP(+)"}
{"X":13994,"RHEA_ID":10586,"compounds":"3 CO2 + 4 CoA + H2O + isoliquiritigenin + NADP(+) => 4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH"}
{"X":13995,"RHEA_ID":20409,"DIRECTION":"UN","MASTER_ID":20409,"ec":"2.7.1.42","metacyc":"RIBOFLAVIN-PHOSPHOTRANSFERASE-RXN","compounds":"alpha-D-glucose 1-phosphate + riboflavin = D-glucose + FMN"}
{"X":13996,"RHEA_ID":10588,"DIRECTION":"UN","MASTER_ID":10588,"ec":"2.3.1.111","compounds":"4 (R)-methylmalonyl-CoA + a long-chain acyl-[mycocerosate synthase] + 12 H(+) + 8 NADPH = a tetramethylated-mycocerosoyl-[mycocerosate synthase] + 4 CO2 + 4 CoA + 4 H2O + 8 NADP(+)"}
{"X":13997,"RHEA_ID":10589,"DIRECTION":"LR","MASTER_ID":10588,"metacyc":"MYCOCEROSATE-SYNTHASE-RXN","compounds":"4 (R)-methylmalonyl-CoA + a long-chain acyl-[mycocerosate synthase] + 12 H(+) + 8 NADPH => a tetramethylated-mycocerosoyl-[mycocerosate synthase] + 4 CO2 + 4 CoA + 4 H2O + 8 NADP(+)"}
{"X":13998,"RHEA_ID":10590,"compounds":"a tetramethylated-mycocerosoyl-[mycocerosate synthase] + 4 CO2 + 4 CoA + 4 H2O + 8 NADP(+) => 4 (R)-methylmalonyl-CoA + a long-chain acyl-[mycocerosate synthase] + 12 H(+) + 8 NADPH"}
{"X":13999,"RHEA_ID":10591,"compounds":"4 (R)-methylmalonyl-CoA + a long-chain acyl-[mycocerosate synthase] + 12 H(+) + 8 NADPH <=> a tetramethylated-mycocerosoyl-[mycocerosate synthase] + 4 CO2 + 4 CoA + 4 H2O + 8 NADP(+)"}
{"X":14000,"RHEA_ID":10592,"compounds":"a 3',5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase] = a 3'-hydroxy,5'-unsubstituted flavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":14001,"RHEA_ID":10593,"DIRECTION":"LR","MASTER_ID":10592,"metacyc":"RXN-7783","compounds":"a 3',5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase] => a 3'-hydroxy,5'-unsubstituted flavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":14002,"RHEA_ID":10594,"compounds":"a 3'-hydroxy,5'-unsubstituted flavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 3',5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":14003,"RHEA_ID":20417,"DIRECTION":"UN","MASTER_ID":20417,"ec":"1.13.12.13","compounds":"coelenterazine + O2 = CO2 + coelenteramide + hnu"}
{"X":14004,"RHEA_ID":10596,"DIRECTION":"UN","MASTER_ID":10596,"ec":"2.7.12.2","compounds":"ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]"}
{"X":14005,"RHEA_ID":10596,"DIRECTION":"UN","MASTER_ID":10596,"ec":"2.7.12.1","compounds":"ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]"}
{"X":14006,"RHEA_ID":10596,"DIRECTION":"UN","MASTER_ID":10596,"ec":"2.7.10.1","compounds":"ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]"}
{"X":14007,"RHEA_ID":10596,"DIRECTION":"UN","MASTER_ID":10596,"ec":"2.7.10.2","compounds":"ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]"}
{"X":14008,"RHEA_ID":10597,"DIRECTION":"LR","MASTER_ID":10596,"ecocyc":"2.7.10.1-RXN","metacyc":"2.7.10.1-RXN","compounds":"ATP + L-tyrosyl-[protein] => ADP + H(+) + O-phospho-L-tyrosyl-[protein]"}
{"X":14009,"RHEA_ID":10598,"compounds":"ADP + H(+) + O-phospho-L-tyrosyl-[protein] => ATP + L-tyrosyl-[protein]"}
{"X":14010,"RHEA_ID":30983,"DIRECTION":"UN","MASTER_ID":30983,"ec":"3.2.1.97","compounds":"H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] = beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-seryl-[protein]"}
{"X":14011,"RHEA_ID":10600,"DIRECTION":"UN","MASTER_ID":10600,"ec":"5.3.99.2","compounds":"prostaglandin H2 = prostaglandin D2"}
{"X":14012,"RHEA_ID":10601,"DIRECTION":"LR","MASTER_ID":10600,"metacyc":"PROSTAGLANDIN-D-SYNTHASE-RXN","reactome":"R-HSA-2161701.3","compounds":"prostaglandin H2 => prostaglandin D2"}
{"X":14013,"RHEA_ID":10601,"DIRECTION":"LR","MASTER_ID":10600,"metacyc":"PROSTAGLANDIN-D-SYNTHASE-RXN","reactome":"R-HSA-2161620.2","compounds":"prostaglandin H2 => prostaglandin D2"}
{"X":14014,"RHEA_ID":10602,"compounds":"prostaglandin D2 => prostaglandin H2"}
{"X":14015,"RHEA_ID":20429,"DIRECTION":"UN","MASTER_ID":20429,"ec":"2.1.1.75","compounds":"apigenin + S-adenosyl-L-methionine = acacetin + H(+) + S-adenosyl-L-homocysteine"}
{"X":14016,"RHEA_ID":10604,"DIRECTION":"UN","MASTER_ID":10604,"ec":"3.1.4.3","compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycerol + H(+) + phosphocholine"}
{"X":14017,"RHEA_ID":10605,"DIRECTION":"LR","MASTER_ID":10604,"metacyc":"PHOSPHOLIPASE-C-RXN","compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O => a 1,2-diacyl-sn-glycerol + H(+) + phosphocholine"}
{"X":14018,"RHEA_ID":10606,"compounds":"a 1,2-diacyl-sn-glycerol + H(+) + phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O"}
{"X":14019,"RHEA_ID":10608,"DIRECTION":"UN","MASTER_ID":10608,"ec":"1.14.14.91","compounds":"O2 + reduced [NADPH--hemoprotein reductase] + trans-cinnamate = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + trans-4-coumarate"}
{"X":14020,"RHEA_ID":10609,"DIRECTION":"LR","MASTER_ID":10608,"metacyc":"TRANS-CINNAMATE-4-MONOOXYGENASE-RXN","compounds":"O2 + reduced [NADPH--hemoprotein reductase] + trans-cinnamate => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + trans-4-coumarate"}
{"X":14021,"RHEA_ID":10610,"compounds":"H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + trans-4-coumarate => O2 + reduced [NADPH--hemoprotein reductase] + trans-cinnamate"}
{"X":14022,"RHEA_ID":20437,"DIRECTION":"UN","MASTER_ID":20437,"ec":"1.1.1.142","compounds":"5D-5-O-methyl-chiro-inositol + NADP(+) = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADPH"}
{"X":14023,"RHEA_ID":10612,"DIRECTION":"UN","MASTER_ID":10612,"ec":"2.4.2.38","compounds":"N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-alpha-D-xylose = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP"}
{"X":14024,"RHEA_ID":10613,"compounds":"N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-alpha-D-xylose => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP"}
{"X":14025,"RHEA_ID":10614,"compounds":"H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-alpha-D-xylose"}
{"X":14026,"RHEA_ID":10616,"DIRECTION":"UN","MASTER_ID":10616,"ec":"1.17.1.3","compounds":"(2R,3S)-catechin + H2O + NADP(+) = (2R,3S,4S)-leucocyanidin + H(+) + NADPH"}
{"X":14027,"RHEA_ID":10617,"compounds":"(2R,3S)-catechin + H2O + NADP(+) => (2R,3S,4S)-leucocyanidin + H(+) + NADPH"}
{"X":14028,"RHEA_ID":10618,"DIRECTION":"RL","MASTER_ID":10616,"metacyc":"RXN-1484","compounds":"(2R,3S,4S)-leucocyanidin + H(+) + NADPH => (2R,3S)-catechin + H2O + NADP(+)"}
{"X":14029,"RHEA_ID":20445,"DIRECTION":"UN","MASTER_ID":20445,"ec":"2.6.1.78","compounds":"L-arogenate + oxaloacetate = L-aspartate + prephenate"}
{"X":14030,"RHEA_ID":10620,"DIRECTION":"UN","MASTER_ID":10620,"ec":"1.2.1.44","compounds":"(E)-cinnamaldehyde + CoA + NADP(+) = (E)-cinnamoyl-CoA + H(+) + NADPH"}
{"X":14031,"RHEA_ID":10621,"compounds":"(E)-cinnamaldehyde + CoA + NADP(+) => (E)-cinnamoyl-CoA + H(+) + NADPH"}
{"X":14032,"RHEA_ID":10622,"compounds":"(E)-cinnamoyl-CoA + H(+) + NADPH => (E)-cinnamaldehyde + CoA + NADP(+)"}
{"X":14033,"RHEA_ID":20449,"DIRECTION":"UN","MASTER_ID":20449,"ec":"1.13.11.36","compounds":"5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one + O2 = 5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one + 2 H(+)"}
{"X":14034,"RHEA_ID":10624,"compounds":"2 ATP + CO2 + H2O + NH4(+) = 2 ADP + carbamoyl phosphate + 3 H(+) + phosphate"}
{"X":14035,"RHEA_ID":10625,"DIRECTION":"LR","MASTER_ID":10624,"metacyc":"6.3.4.16-RXN","compounds":"2 ATP + CO2 + H2O + NH4(+) => 2 ADP + carbamoyl phosphate + 3 H(+) + phosphate"}
{"X":14036,"RHEA_ID":10626,"compounds":"2 ADP + carbamoyl phosphate + 3 H(+) + phosphate => 2 ATP + CO2 + H2O + NH4(+)"}
{"X":14037,"RHEA_ID":20453,"DIRECTION":"UN","MASTER_ID":20453,"ec":"2.4.1.128","compounds":"scopoletin + UDP-alpha-D-glucose = H(+) + scopolin + UDP"}
{"X":14038,"RHEA_ID":10628,"DIRECTION":"UN","MASTER_ID":10628,"ec":"2.7.7.56","compounds":"phosphate + tRNA(n+1) = a ribonucleoside 5'-diphosphate + tRNA(n)"}
{"X":14039,"RHEA_ID":10629,"compounds":"phosphate + tRNA(n+1) => a ribonucleoside 5'-diphosphate + tRNA(n)"}
{"X":14040,"RHEA_ID":10630,"compounds":"a ribonucleoside 5'-diphosphate + tRNA(n) => phosphate + tRNA(n+1)"}
{"X":14041,"RHEA_ID":10632,"DIRECTION":"UN","MASTER_ID":10632,"ec":"1.1.1.131","compounds":"D-mannonate + NAD(+) = D-mannuronate + H(+) + NADH"}
{"X":14042,"RHEA_ID":10633,"compounds":"D-mannonate + NAD(+) => D-mannuronate + H(+) + NADH"}
{"X":14043,"RHEA_ID":10634,"compounds":"D-mannuronate + H(+) + NADH => D-mannonate + NAD(+)"}
{"X":14044,"RHEA_ID":20459,"compounds":"D-arabinono-1,4-lactone + H(+) + NADH => D-arabinose + NAD(+)"}
{"X":14045,"RHEA_ID":10636,"DIRECTION":"UN","MASTER_ID":10636,"ec":"1.1.1.131","compounds":"D-mannonate + NADP(+) = D-mannuronate + H(+) + NADPH"}
{"X":14046,"RHEA_ID":10637,"compounds":"D-mannonate + NADP(+) => D-mannuronate + H(+) + NADPH"}
{"X":14047,"RHEA_ID":10638,"compounds":"D-mannuronate + H(+) + NADPH => D-mannonate + NADP(+)"}
{"X":14048,"RHEA_ID":20463,"compounds":"an N,N,N-trimethylornithine lipid + 3 H(+) + 3 S-adenosyl-L-homocysteine => an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + 3 S-adenosyl-L-methionine"}
{"X":14049,"RHEA_ID":10640,"compounds":"muconolactone = cis,cis-muconate + H(+)"}
{"X":14050,"RHEA_ID":10641,"compounds":"muconolactone => cis,cis-muconate + H(+)"}
{"X":14051,"RHEA_ID":10642,"DIRECTION":"RL","MASTER_ID":10640,"macie":"M0269","compounds":"cis,cis-muconate + H(+) => muconolactone"}
{"X":14052,"RHEA_ID":20467,"compounds":"H(+) + N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP => [hyaluronan](n) + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":14053,"RHEA_ID":10644,"DIRECTION":"UN","MASTER_ID":10644,"ec":"3.1.1.57","compounds":"2-oxo-2H-pyran-4,6-dicarboxylate + H2O = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H(+)"}
{"X":14054,"RHEA_ID":10645,"compounds":"2-oxo-2H-pyran-4,6-dicarboxylate + H2O => (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H(+)"}
{"X":14055,"RHEA_ID":10646,"compounds":"(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H(+) => 2-oxo-2H-pyran-4,6-dicarboxylate + H2O"}
{"X":14056,"RHEA_ID":20471,"compounds":"D-ribose 5-phosphate + hypoxanthine => H2O + IMP"}
{"X":14057,"RHEA_ID":10648,"compounds":"2-hydroxycyclohexan-1-one + H(+) + NADPH + O2 = 6-hydroxyhexan-6-olide + H2O + NADP(+)"}
{"X":14058,"RHEA_ID":10649,"DIRECTION":"LR","MASTER_ID":10648,"metacyc":"1.14.13.66-RXN","compounds":"2-hydroxycyclohexan-1-one + H(+) + NADPH + O2 => 6-hydroxyhexan-6-olide + H2O + NADP(+)"}
{"X":14059,"RHEA_ID":10650,"compounds":"6-hydroxyhexan-6-olide + H2O + NADP(+) => 2-hydroxycyclohexan-1-one + H(+) + NADPH + O2"}
{"X":14060,"RHEA_ID":20475,"compounds":"[lipoyl-carrier protein]-(R)-N(6)-lipoyl-L-lysine + AMP + 2 H(+) => (R)-lipoyl-5'-AMP + [lipoyl-carrier protein]-L-lysine"}
{"X":14061,"RHEA_ID":10652,"DIRECTION":"UN","MASTER_ID":10652,"ec":"1.2.1.48","compounds":"a long-chain fatty aldehyde + H2O + NAD(+) = a long-chain fatty acid + 2 H(+) + NADH"}
{"X":14062,"RHEA_ID":10653,"compounds":"a long-chain fatty aldehyde + H2O + NAD(+) => a long-chain fatty acid + 2 H(+) + NADH"}
{"X":14063,"RHEA_ID":10654,"compounds":"a long-chain fatty acid + 2 H(+) + NADH => a long-chain fatty aldehyde + H2O + NAD(+)"}
{"X":14064,"RHEA_ID":10656,"DIRECTION":"UN","MASTER_ID":10656,"ec":"2.1.1.2","compounds":"guanidinoacetate + S-adenosyl-L-methionine = creatine + H(+) + S-adenosyl-L-homocysteine"}
{"X":14065,"RHEA_ID":10657,"DIRECTION":"LR","MASTER_ID":10656,"metacyc":"GUANIDINOACETATE-N-METHYLTRANSFERASE-RXN","reactome":"R-HSA-71286.2","compounds":"guanidinoacetate + S-adenosyl-L-methionine => creatine + H(+) + S-adenosyl-L-homocysteine"}
{"X":14066,"RHEA_ID":10658,"compounds":"creatine + H(+) + S-adenosyl-L-homocysteine => guanidinoacetate + S-adenosyl-L-methionine"}
{"X":14067,"RHEA_ID":20487,"compounds":"(S)-cheilanthifoline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":14068,"RHEA_ID":10660,"DIRECTION":"UN","MASTER_ID":10660,"ec":"5.1.1.16","metacyc":"5.1.1.16-RXN","compounds":"L-seryl-[protein] = D-seryl-[protein]"}
{"X":14069,"RHEA_ID":10661,"compounds":"L-seryl-[protein] => D-seryl-[protein]"}
{"X":14070,"RHEA_ID":10662,"compounds":"D-seryl-[protein] => L-seryl-[protein]"}
{"X":14071,"RHEA_ID":10664,"DIRECTION":"UN","MASTER_ID":10664,"ec":"1.1.1.144","compounds":"NAD(+) + perillyl alcohol = H(+) + NADH + perillyl aldehyde"}
{"X":14072,"RHEA_ID":10665,"DIRECTION":"LR","MASTER_ID":10664,"metacyc":"PERILLYL-ALCOHOL-DEHYDROGENASE-RXN","compounds":"NAD(+) + perillyl alcohol => H(+) + NADH + perillyl aldehyde"}
{"X":14073,"RHEA_ID":10666,"compounds":"H(+) + NADH + perillyl aldehyde => NAD(+) + perillyl alcohol"}
{"X":14074,"RHEA_ID":20495,"compounds":"an N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-galactosamine"}
{"X":14075,"RHEA_ID":10668,"DIRECTION":"UN","MASTER_ID":10668,"ec":"2.3.2.3","compounds":"1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys)"}
{"X":14076,"RHEA_ID":10669,"DIRECTION":"LR","MASTER_ID":10668,"metacyc":"LYSYLTRANSFERASE-RXN","compounds":"1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) => 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys)"}
{"X":14077,"RHEA_ID":10670,"compounds":"1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys)"}
{"X":14078,"RHEA_ID":10672,"DIRECTION":"UN","MASTER_ID":10672,"ec":"4.1.99.3","compounds":"cyclobutadithymidine in DNA = a thymidine dimer in DNA"}
{"X":14079,"RHEA_ID":10673,"compounds":"cyclobutadithymidine in DNA => a thymidine dimer in DNA"}
{"X":14080,"RHEA_ID":10674,"compounds":"a thymidine dimer in DNA => cyclobutadithymidine in DNA"}
{"X":14081,"RHEA_ID":10676,"compounds":"(2R,3S)-3-isopropylmalate = 2-isopropylmaleate + H2O"}
{"X":14082,"RHEA_ID":10677,"compounds":"(2R,3S)-3-isopropylmalate => 2-isopropylmaleate + H2O"}
{"X":14083,"RHEA_ID":10678,"DIRECTION":"RL","MASTER_ID":10676,"ecocyc":"RXN-8991","metacyc":"RXN-8991","compounds":"2-isopropylmaleate + H2O => (2R,3S)-3-isopropylmalate"}
{"X":14084,"RHEA_ID":20511,"compounds":"ADP + H(+) + O-phosphoviomycin => ATP + viomycin"}
{"X":14085,"RHEA_ID":10680,"DIRECTION":"UN","MASTER_ID":10680,"ec":"5.1.1.4","compounds":"L-proline = D-proline"}
{"X":14086,"RHEA_ID":10681,"compounds":"L-proline => D-proline"}
{"X":14087,"RHEA_ID":10682,"compounds":"D-proline => L-proline"}
{"X":14088,"RHEA_ID":20515,"compounds":"2-arylpropionate + CO2 => 2-aryl-2-methylmalonate + H(+)"}
{"X":14089,"RHEA_ID":10684,"DIRECTION":"UN","MASTER_ID":10684,"ec":"3.1.3.48","compounds":"H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate"}
{"X":14090,"RHEA_ID":10685,"DIRECTION":"LR","MASTER_ID":10684,"ecocyc":"PROTEIN-TYROSINE-PHOSPHATASE-RXN","metacyc":"PROTEIN-TYROSINE-PHOSPHATASE-RXN","compounds":"H2O + O-phospho-L-tyrosyl-[protein] => L-tyrosyl-[protein] + phosphate"}
{"X":14091,"RHEA_ID":10686,"compounds":"L-tyrosyl-[protein] + phosphate => H2O + O-phospho-L-tyrosyl-[protein]"}
{"X":14092,"RHEA_ID":10688,"DIRECTION":"UN","MASTER_ID":10688,"ec":"3.1.3.39","compounds":"H2O + streptomycin 6-phosphate = phosphate + streptomycin"}
{"X":14093,"RHEA_ID":10689,"DIRECTION":"LR","MASTER_ID":10688,"metacyc":"STREPTOMYCIN-6-PHOSPHATASE-RXN","compounds":"H2O + streptomycin 6-phosphate => phosphate + streptomycin"}
{"X":14094,"RHEA_ID":10690,"compounds":"phosphate + streptomycin => H2O + streptomycin 6-phosphate"}
{"X":14095,"RHEA_ID":20522,"DIRECTION":"LR","MASTER_ID":20521,"reactome":"R-HSA-73920.2","compounds":"(R)-3-hydroxybutanoate + NAD(+) => acetoacetate + H(+) + NADH"}
{"X":14096,"RHEA_ID":10692,"DIRECTION":"UN","MASTER_ID":10692,"ec":"1.3.3.11","compounds":"6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = H(+) + 2 H2O + 2 H2O2 + pyrroloquinoline quinone"}
{"X":14097,"RHEA_ID":10693,"compounds":"6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 => H(+) + 2 H2O + 2 H2O2 + pyrroloquinoline quinone"}
{"X":14098,"RHEA_ID":10694,"compounds":"H(+) + 2 H2O + 2 H2O2 + pyrroloquinoline quinone => 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2"}
{"X":14099,"RHEA_ID":20526,"DIRECTION":"LR","MASTER_ID":20525,"metacyc":"RXN-12905","compounds":"ATP + ethylamine + L-glutamate => ADP + H(+) + N(5)-ethyl-L-glutamine + phosphate"}
{"X":14100,"RHEA_ID":10696,"DIRECTION":"UN","MASTER_ID":10696,"ec":"6.2.1.49","compounds":"a holo-[mycocerosate synthase] + a long-chain fatty acid + ATP = a long-chain acyl-[mycocerosate synthase] + AMP + diphosphate"}
{"X":14101,"RHEA_ID":10697,"DIRECTION":"LR","MASTER_ID":10696,"metacyc":"RXN-18531","compounds":"a holo-[mycocerosate synthase] + a long-chain fatty acid + ATP => a long-chain acyl-[mycocerosate synthase] + AMP + diphosphate"}
{"X":14102,"RHEA_ID":10698,"compounds":"a long-chain acyl-[mycocerosate synthase] + AMP + diphosphate => a holo-[mycocerosate synthase] + a long-chain fatty acid + ATP"}
{"X":14103,"RHEA_ID":10699,"compounds":"a holo-[mycocerosate synthase] + a long-chain fatty acid + ATP <=> a long-chain acyl-[mycocerosate synthase] + AMP + diphosphate"}
{"X":14104,"RHEA_ID":10700,"DIRECTION":"UN","MASTER_ID":10700,"ec":"3.3.2.8","compounds":"H2O + limonene 1,2-epoxide = limonene-1,2-diol"}
{"X":14105,"RHEA_ID":10701,"DIRECTION":"LR","MASTER_ID":10700,"metacyc":"RXN-9412","compounds":"H2O + limonene 1,2-epoxide => limonene-1,2-diol"}
{"X":14106,"RHEA_ID":10702,"compounds":"limonene-1,2-diol => H2O + limonene 1,2-epoxide"}
{"X":14107,"RHEA_ID":20534,"DIRECTION":"LR","MASTER_ID":20533,"ecocyc":"3.1.3.74-RXN","metacyc":"3.1.3.74-RXN","compounds":"H2O + pyridoxal 5'-phosphate => phosphate + pyridoxal"}
{"X":14108,"RHEA_ID":10704,"DIRECTION":"UN","MASTER_ID":10704,"ec":"6.1.1.9","compounds":"ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)"}
{"X":14109,"RHEA_ID":10705,"DIRECTION":"LR","MASTER_ID":10704,"ecocyc":"VALINE--TRNA-LIGASE-RXN","metacyc":"VALINE--TRNA-LIGASE-RXN","compounds":"ATP + L-valine + tRNA(Val) => AMP + diphosphate + L-valyl-tRNA(Val)"}
{"X":14110,"RHEA_ID":10706,"compounds":"AMP + diphosphate + L-valyl-tRNA(Val) => ATP + L-valine + tRNA(Val)"}
{"X":14111,"RHEA_ID":20538,"DIRECTION":"LR","MASTER_ID":20537,"ecocyc":"3.1.4.14-RXN","metacyc":"3.1.4.14-RXN","compounds":"H2O + holo-[ACP] => apo-[ACP] + D-pantetheine 4'-phosphate + H(+)"}
{"X":14112,"RHEA_ID":10708,"DIRECTION":"UN","MASTER_ID":10708,"ec":"2.7.7.34","compounds":"alpha-D-glucose 1-phosphate + GTP + H(+) = diphosphate + GDP-D-glucose"}
{"X":14113,"RHEA_ID":10709,"DIRECTION":"LR","MASTER_ID":10708,"metacyc":"2.7.7.34-RXN","compounds":"alpha-D-glucose 1-phosphate + GTP + H(+) => diphosphate + GDP-D-glucose"}
{"X":14114,"RHEA_ID":10710,"compounds":"diphosphate + GDP-D-glucose => alpha-D-glucose 1-phosphate + GTP + H(+)"}
{"X":14115,"RHEA_ID":20542,"DIRECTION":"LR","MASTER_ID":20541,"metacyc":"RXN-5283","compounds":"H(+) + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADPH + O2 => 2 H2O + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADP(+)"}
{"X":14116,"RHEA_ID":10712,"DIRECTION":"UN","MASTER_ID":10712,"ec":"1.13.12.9","compounds":"L-phenylalanine + O2 = 2-phenylacetamide + CO2 + H2O"}
{"X":14117,"RHEA_ID":10713,"DIRECTION":"LR","MASTER_ID":10712,"metacyc":"PHENYLALANINE-2-MONOOXYGENASE-RXN","compounds":"L-phenylalanine + O2 => 2-phenylacetamide + CO2 + H2O"}
{"X":14118,"RHEA_ID":10714,"compounds":"2-phenylacetamide + CO2 + H2O => L-phenylalanine + O2"}
{"X":14119,"RHEA_ID":20546,"DIRECTION":"LR","MASTER_ID":20545,"metacyc":"KYNURENINE-3-MONOOXYGENASE-RXN","reactome":"R-HSA-71200.2","compounds":"H(+) + L-kynurenine + NADPH + O2 => 3-hydroxy-L-kynurenine + H2O + NADP(+)"}
{"X":14120,"RHEA_ID":10716,"DIRECTION":"UN","MASTER_ID":10716,"ec":"5.5.1.4","compounds":"D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate"}
{"X":14121,"RHEA_ID":10717,"DIRECTION":"LR","MASTER_ID":10716,"metacyc":"MYO-INOSITOL-1-PHOSPHATE-SYNTHASE-RXN","reactome":"R-HSA-1855178.2","compounds":"D-glucose 6-phosphate => 1D-myo-inositol 3-phosphate"}
{"X":14122,"RHEA_ID":10718,"compounds":"1D-myo-inositol 3-phosphate => D-glucose 6-phosphate"}
{"X":14123,"RHEA_ID":20550,"DIRECTION":"LR","MASTER_ID":20549,"metacyc":"THIOSULFATE-DEHYDROGENASE-RXN","compounds":"2 [Fe(III)cytochrome c] + 2 thiosulfate => 2 [Fe(II)cytochrome c] + 2 H(+) + tetrathionate"}
{"X":14124,"RHEA_ID":10720,"DIRECTION":"UN","MASTER_ID":10720,"ec":"1.5.4.1","compounds":"2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 glutathione"}
{"X":14125,"RHEA_ID":10721,"compounds":"2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O => 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 glutathione"}
{"X":14126,"RHEA_ID":10722,"DIRECTION":"RL","MASTER_ID":10720,"metacyc":"1.5.4.1-RXN","compounds":"6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 glutathione => 2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O"}
{"X":14127,"RHEA_ID":20554,"DIRECTION":"LR","MASTER_ID":20553,"macie":"M0033","compounds":"(R)-methylmalonyl-CoA => (S)-methylmalonyl-CoA"}
{"X":14128,"RHEA_ID":10724,"DIRECTION":"UN","MASTER_ID":10724,"ec":"1.1.1.135","compounds":"GDP-6-deoxy-alpha-D-talose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH"}
{"X":14129,"RHEA_ID":10724,"DIRECTION":"UN","MASTER_ID":10724,"ec":"1.1.1.187","compounds":"GDP-6-deoxy-alpha-D-talose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH"}
{"X":14130,"RHEA_ID":10725,"compounds":"GDP-6-deoxy-alpha-D-talose + NADP(+) => GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH"}
{"X":14131,"RHEA_ID":10726,"DIRECTION":"RL","MASTER_ID":10724,"metacyc":"GDP-6-DEOXY-D-TALOSE-4-DEHYDROGENASE-RXN","compounds":"GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH => GDP-6-deoxy-alpha-D-talose + NADP(+)"}
{"X":14132,"RHEA_ID":20559,"compounds":"CO2 + 2 NH4(+) => 2 H(+) + H2O + urea"}
{"X":14133,"RHEA_ID":10728,"DIRECTION":"UN","MASTER_ID":10728,"ec":"1.1.1.135","compounds":"GDP-6-deoxy-alpha-D-talose + NAD(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH"}
{"X":14134,"RHEA_ID":10728,"DIRECTION":"UN","MASTER_ID":10728,"ec":"1.1.1.187","compounds":"GDP-6-deoxy-alpha-D-talose + NAD(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH"}
{"X":14135,"RHEA_ID":10729,"compounds":"GDP-6-deoxy-alpha-D-talose + NAD(+) => GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH"}
{"X":14136,"RHEA_ID":10730,"DIRECTION":"RL","MASTER_ID":10728,"metacyc":"GDP-6-DEOXY-D-TALOSE-4-DEHYDROGENASE-RXN","compounds":"GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH => GDP-6-deoxy-alpha-D-talose + NAD(+)"}
{"X":14137,"RHEA_ID":10732,"DIRECTION":"UN","MASTER_ID":10732,"ec":"1.13.12.7","compounds":"ATP + firefly D-luciferin + O2 = AMP + CO2 + diphosphate + firefly oxyluciferin + hnu"}
{"X":14138,"RHEA_ID":10733,"DIRECTION":"LR","MASTER_ID":10732,"macie":"M0128","metacyc":"1.13.12.7-RXN","compounds":"ATP + firefly D-luciferin + O2 => AMP + CO2 + diphosphate + firefly oxyluciferin + hnu"}
{"X":14139,"RHEA_ID":10734,"compounds":"AMP + CO2 + diphosphate + firefly oxyluciferin + hnu => ATP + firefly D-luciferin + O2"}
{"X":14140,"RHEA_ID":41092,"compounds":"a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => 1-(9Z-octadecenoyl)-sn-glycerol + H(+) + phosphocholine"}
{"X":14141,"RHEA_ID":10736,"DIRECTION":"UN","MASTER_ID":10736,"ec":"1.1.1.1","compounds":"a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH"}
{"X":14142,"RHEA_ID":10736,"DIRECTION":"UN","MASTER_ID":10736,"ec":"1.1.1.71","compounds":"a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH"}
{"X":14143,"RHEA_ID":10737,"compounds":"a primary alcohol + NAD(+) => an aldehyde + H(+) + NADH"}
{"X":14144,"RHEA_ID":10738,"DIRECTION":"RL","MASTER_ID":10736,"metacyc":"ALCOHOL-DEHYDROGENASE-NADP%2b-RXN","compounds":"an aldehyde + H(+) + NADH => a primary alcohol + NAD(+)"}
{"X":14145,"RHEA_ID":10740,"DIRECTION":"UN","MASTER_ID":10740,"ec":"1.1.1.1","compounds":"a secondary alcohol + NAD(+) = a ketone + H(+) + NADH"}
{"X":14146,"RHEA_ID":10741,"compounds":"a secondary alcohol + NAD(+) => a ketone + H(+) + NADH"}
{"X":14147,"RHEA_ID":10742,"compounds":"a ketone + H(+) + NADH => a secondary alcohol + NAD(+)"}
{"X":14148,"RHEA_ID":10744,"DIRECTION":"UN","MASTER_ID":10744,"ec":"1.3.1.53","compounds":"(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+) = 3,4-dihydroxybenzoate + CO2 + NADH"}
{"X":14149,"RHEA_ID":10745,"compounds":"(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+) => 3,4-dihydroxybenzoate + CO2 + NADH"}
{"X":14150,"RHEA_ID":10746,"compounds":"3,4-dihydroxybenzoate + CO2 + NADH => (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+)"}
{"X":14151,"RHEA_ID":31135,"compounds":"5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + diphosphate = 5-amino-4-imidazolecarboxyamide + 5-phospho-alpha-D-ribose 1-diphosphate"}
{"X":14152,"RHEA_ID":10748,"DIRECTION":"UN","MASTER_ID":10748,"ec":"4.2.1.1","compounds":"H(+) + hydrogencarbonate = CO2 + H2O"}
{"X":14153,"RHEA_ID":10749,"DIRECTION":"LR","MASTER_ID":10748,"reactome":"R-HSA-1237059.2","compounds":"H(+) + hydrogencarbonate => CO2 + H2O"}
{"X":14154,"RHEA_ID":10749,"DIRECTION":"LR","MASTER_ID":10748,"reactome":"R-HSA-1237081.1","compounds":"H(+) + hydrogencarbonate => CO2 + H2O"}
{"X":14155,"RHEA_ID":10749,"DIRECTION":"LR","MASTER_ID":10748,"reactome":"R-HSA-1475017.1","compounds":"H(+) + hydrogencarbonate => CO2 + H2O"}
{"X":14156,"RHEA_ID":10749,"DIRECTION":"LR","MASTER_ID":10748,"reactome":"R-HSA-1475022.1","compounds":"H(+) + hydrogencarbonate => CO2 + H2O"}
{"X":14157,"RHEA_ID":10749,"DIRECTION":"LR","MASTER_ID":10748,"reactome":"R-HSA-1475028.1","compounds":"H(+) + hydrogencarbonate => CO2 + H2O"}
{"X":14158,"RHEA_ID":10749,"DIRECTION":"LR","MASTER_ID":10748,"reactome":"R-HSA-1475436.1","compounds":"H(+) + hydrogencarbonate => CO2 + H2O"}
{"X":14159,"RHEA_ID":10750,"DIRECTION":"RL","MASTER_ID":10748,"macie":"M0216","reactome":"R-HSA-1475025.1","compounds":"CO2 + H2O => H(+) + hydrogencarbonate"}
{"X":14160,"RHEA_ID":10750,"DIRECTION":"RL","MASTER_ID":10748,"macie":"M0216","reactome":"R-HSA-1237047.1","compounds":"CO2 + H2O => H(+) + hydrogencarbonate"}
{"X":14161,"RHEA_ID":10750,"DIRECTION":"RL","MASTER_ID":10748,"macie":"M0216","reactome":"R-HSA-1475026.2","compounds":"CO2 + H2O => H(+) + hydrogencarbonate"}
{"X":14162,"RHEA_ID":10750,"DIRECTION":"RL","MASTER_ID":10748,"macie":"M0216","reactome":"R-HSA-1475435.1","compounds":"CO2 + H2O => H(+) + hydrogencarbonate"}
{"X":14163,"RHEA_ID":10750,"DIRECTION":"RL","MASTER_ID":10748,"macie":"M0216","reactome":"R-HSA-1237045.1","compounds":"CO2 + H2O => H(+) + hydrogencarbonate"}
{"X":14164,"RHEA_ID":10750,"DIRECTION":"RL","MASTER_ID":10748,"macie":"M0216","reactome":"R-HSA-1475032.1","compounds":"CO2 + H2O => H(+) + hydrogencarbonate"}
{"X":14165,"RHEA_ID":10752,"DIRECTION":"UN","MASTER_ID":10752,"ec":"6.3.1.12","compounds":"[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n) + n ATP + n D-aspartate = [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + n ADP + n H(+) + n phosphate"}
{"X":14166,"RHEA_ID":10753,"compounds":"[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n) + n ATP + n D-aspartate => [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + n ADP + n H(+) + n phosphate"}
{"X":14167,"RHEA_ID":10754,"compounds":"[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + n ADP + n H(+) + n phosphate => [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n) + n ATP + n D-aspartate"}
{"X":14168,"RHEA_ID":20599,"DIRECTION":"RL","MASTER_ID":20597,"metacyc":"CYSTINE-REDUCTASE-NADH-RXN","compounds":"H(+) + L-cystine + NADH => 2 L-cysteine + NAD(+)"}
{"X":14169,"RHEA_ID":10756,"DIRECTION":"UN","MASTER_ID":10756,"ec":"2.7.9.1","compounds":"ATP + phosphate + pyruvate = AMP + diphosphate + H(+) + phosphoenolpyruvate"}
{"X":14170,"RHEA_ID":10757,"DIRECTION":"LR","MASTER_ID":10756,"macie":"M0207","metacyc":"PYRUVATEORTHOPHOSPHATE-DIKINASE-RXN","compounds":"ATP + phosphate + pyruvate => AMP + diphosphate + H(+) + phosphoenolpyruvate"}
{"X":14171,"RHEA_ID":10758,"compounds":"AMP + diphosphate + H(+) + phosphoenolpyruvate => ATP + phosphate + pyruvate"}
{"X":14172,"RHEA_ID":20603,"compounds":"H(+) + NADH + S-formylmycothiol => formaldehyde + mycothiol + NAD(+)"}
{"X":14173,"RHEA_ID":10760,"DIRECTION":"UN","MASTER_ID":10760,"ec":"4.1.3.6","compounds":"citrate = acetate + oxaloacetate"}
{"X":14174,"RHEA_ID":10761,"DIRECTION":"LR","MASTER_ID":10760,"ecocyc":"CITLY-RXN","metacyc":"CITLY-RXN","compounds":"citrate => acetate + oxaloacetate"}
{"X":14175,"RHEA_ID":10762,"compounds":"acetate + oxaloacetate => citrate"}
{"X":14176,"RHEA_ID":20607,"compounds":"NH4(+) + uracil => cytosine + H(+) + H2O"}
{"X":14177,"RHEA_ID":10764,"DIRECTION":"UN","MASTER_ID":10764,"ec":"1.14.20.4","compounds":"(2R,3S,4S)-leucocyanidin + 2-oxoglutarate + O2 = (4S)-2,3-dehydroleucocyanidin + CO2 + H(+) + H2O + succinate"}
{"X":14178,"RHEA_ID":10765,"DIRECTION":"LR","MASTER_ID":10764,"metacyc":"RXN-602","compounds":"(2R,3S,4S)-leucocyanidin + 2-oxoglutarate + O2 => (4S)-2,3-dehydroleucocyanidin + CO2 + H(+) + H2O + succinate"}
{"X":14179,"RHEA_ID":10766,"compounds":"(4S)-2,3-dehydroleucocyanidin + CO2 + H(+) + H2O + succinate => (2R,3S,4S)-leucocyanidin + 2-oxoglutarate + O2"}
{"X":14180,"RHEA_ID":20611,"compounds":"glycolaldehyde + pyruvate => 2-dehydro-3-deoxy-D-arabinonate"}
{"X":14181,"RHEA_ID":10768,"DIRECTION":"UN","MASTER_ID":10768,"ec":"1.14.20.4","compounds":"(2R,3S,4S)-3,4-leucopelargonidin + 2-oxoglutarate + O2 = (4S)-2,3-dehydroleucopelargonidin + CO2 + H(+) + H2O + succinate"}
{"X":14182,"RHEA_ID":10769,"DIRECTION":"LR","MASTER_ID":10768,"metacyc":"LEUCPEL-RXN","compounds":"(2R,3S,4S)-3,4-leucopelargonidin + 2-oxoglutarate + O2 => (4S)-2,3-dehydroleucopelargonidin + CO2 + H(+) + H2O + succinate"}
{"X":14183,"RHEA_ID":10770,"compounds":"(4S)-2,3-dehydroleucopelargonidin + CO2 + H(+) + H2O + succinate => (2R,3S,4S)-3,4-leucopelargonidin + 2-oxoglutarate + O2"}
{"X":14184,"RHEA_ID":20615,"compounds":"adenosine 3',5'-bisphosphate + H(+) + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine => 3'-phosphoadenylyl sulfate + a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine"}
{"X":14185,"RHEA_ID":10772,"DIRECTION":"UN","MASTER_ID":10772,"ec":"3.2.1.86","compounds":"6-phospho-beta-D-glucosyl-(1->4)-D-glucose + H2O = D-glucose + D-glucose 6-phosphate"}
{"X":14186,"RHEA_ID":10773,"DIRECTION":"LR","MASTER_ID":10772,"ecocyc":"6-PHOSPHO-BETA-GLUCOSIDASE-RXN","metacyc":"6-PHOSPHO-BETA-GLUCOSIDASE-RXN","compounds":"6-phospho-beta-D-glucosyl-(1->4)-D-glucose + H2O => D-glucose + D-glucose 6-phosphate"}
{"X":14187,"RHEA_ID":10774,"compounds":"D-glucose + D-glucose 6-phosphate => 6-phospho-beta-D-glucosyl-(1->4)-D-glucose + H2O"}
{"X":14188,"RHEA_ID":20619,"compounds":"H(+) + H2O2 + L-ascorbate => L-galactono-1,4-lactone + O2"}
{"X":14189,"RHEA_ID":10776,"DIRECTION":"UN","MASTER_ID":10776,"ec":"1.1.1.222","compounds":"(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NADP(+) = 3-(4-hydroxyphenyl)pyruvate + H(+) + NADPH"}
{"X":14190,"RHEA_ID":10776,"DIRECTION":"UN","MASTER_ID":10776,"ec":"1.1.1.237","compounds":"(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NADP(+) = 3-(4-hydroxyphenyl)pyruvate + H(+) + NADPH"}
{"X":14191,"RHEA_ID":10777,"DIRECTION":"LR","MASTER_ID":10776,"metacyc":"1.1.1.222-RXN","compounds":"(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NADP(+) => 3-(4-hydroxyphenyl)pyruvate + H(+) + NADPH"}
{"X":14192,"RHEA_ID":10778,"compounds":"3-(4-hydroxyphenyl)pyruvate + H(+) + NADPH => (2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NADP(+)"}
{"X":14193,"RHEA_ID":31179,"compounds":"(3S)-hydroxydodecanoyl-CoA + NAD(+) = 3-oxododecanoyl-CoA + H(+) + NADH"}
{"X":14194,"RHEA_ID":10780,"DIRECTION":"UN","MASTER_ID":10780,"ec":"1.1.1.110","compounds":"(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+) = 3-(4-hydroxyphenyl)pyruvate + H(+) + NADH"}
{"X":14195,"RHEA_ID":10780,"DIRECTION":"UN","MASTER_ID":10780,"ec":"1.1.1.222","compounds":"(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+) = 3-(4-hydroxyphenyl)pyruvate + H(+) + NADH"}
{"X":14196,"RHEA_ID":10780,"DIRECTION":"UN","MASTER_ID":10780,"ec":"1.1.1.237","compounds":"(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+) = 3-(4-hydroxyphenyl)pyruvate + H(+) + NADH"}
{"X":14197,"RHEA_ID":10781,"DIRECTION":"LR","MASTER_ID":10780,"metacyc":"1.1.1.222-RXN","compounds":"(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+) => 3-(4-hydroxyphenyl)pyruvate + H(+) + NADH"}
{"X":14198,"RHEA_ID":10782,"compounds":"3-(4-hydroxyphenyl)pyruvate + H(+) + NADH => (2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+)"}
{"X":14199,"RHEA_ID":20630,"DIRECTION":"LR","MASTER_ID":20629,"ecocyc":"3.1.3.16-RXN","metacyc":"3.1.3.16-RXN","compounds":"H2O + O-phospho-L-seryl-[protein] => L-seryl-[protein] + phosphate"}
{"X":14200,"RHEA_ID":10784,"compounds":"2-oxoglutarate + N(6)-methyl-L-lysyl(36)-[histone H3] + O2 = CO2 + formaldehyde + L-lysyl(36)-[histone H3] + succinate"}
{"X":14201,"RHEA_ID":10785,"DIRECTION":"LR","MASTER_ID":10784,"metacyc":"RXN-20637","compounds":"2-oxoglutarate + N(6)-methyl-L-lysyl(36)-[histone H3] + O2 => CO2 + formaldehyde + L-lysyl(36)-[histone H3] + succinate"}
{"X":14202,"RHEA_ID":10786,"compounds":"CO2 + formaldehyde + L-lysyl(36)-[histone H3] + succinate => 2-oxoglutarate + N(6)-methyl-L-lysyl(36)-[histone H3] + O2"}
{"X":14203,"RHEA_ID":20634,"DIRECTION":"LR","MASTER_ID":20633,"metacyc":"RXN-12431","compounds":"a (3R)-hydroxyacyl-[ACP] + L-ornithine => a lyso-ornithine lipid + H(+) + holo-[ACP]"}
{"X":14204,"RHEA_ID":10788,"DIRECTION":"UN","MASTER_ID":10788,"ec":"2.7.1.13","compounds":"2-dehydro-D-gluconate + ATP = 6-phospho-2-dehydro-D-gluconate + ADP + H(+)"}
{"X":14205,"RHEA_ID":10789,"DIRECTION":"LR","MASTER_ID":10788,"metacyc":"DEHYDOGLUCONOKINASE-RXN","compounds":"2-dehydro-D-gluconate + ATP => 6-phospho-2-dehydro-D-gluconate + ADP + H(+)"}
{"X":14206,"RHEA_ID":10790,"compounds":"6-phospho-2-dehydro-D-gluconate + ADP + H(+) => 2-dehydro-D-gluconate + ATP"}
{"X":14207,"RHEA_ID":20638,"DIRECTION":"LR","MASTER_ID":20637,"metacyc":"1.1.99.28-RXN","compounds":"D-fructose + D-glucose => D-glucono-1,5-lactone + D-sorbitol"}
{"X":14208,"RHEA_ID":10792,"DIRECTION":"UN","MASTER_ID":10792,"ec":"4.1.1.21","compounds":"5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2"}
{"X":14209,"RHEA_ID":10793,"compounds":"5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2"}
{"X":14210,"RHEA_ID":10794,"compounds":"5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2 => 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+)"}
{"X":14211,"RHEA_ID":20642,"compounds":"H2O + L-histidinol + 2 NAD(+) => 3 H(+) + L-histidine + 2 NADH"}
{"X":14212,"RHEA_ID":10796,"DIRECTION":"UN","MASTER_ID":10796,"ec":"1.14.13.32","compounds":"albendazole + H(+) + NADPH + O2 = albendazole S-oxide + H2O + NADP(+)"}
{"X":14213,"RHEA_ID":10797,"DIRECTION":"LR","MASTER_ID":10796,"metacyc":"ALBENDAZOLE-MONOOXYGENASE-RXN","compounds":"albendazole + H(+) + NADPH + O2 => albendazole S-oxide + H2O + NADP(+)"}
{"X":14214,"RHEA_ID":10798,"compounds":"albendazole S-oxide + H2O + NADP(+) => albendazole + H(+) + NADPH + O2"}
{"X":14215,"RHEA_ID":20650,"compounds":"23,24-dihydrocucurbitacin B + NADP(+) => cucurbitacin B + H(+) + NADPH"}
{"X":14216,"RHEA_ID":10800,"DIRECTION":"UN","MASTER_ID":10800,"ec":"2.4.2.22","compounds":"diphosphate + XMP = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine"}
{"X":14217,"RHEA_ID":10801,"compounds":"diphosphate + XMP => 5-phospho-alpha-D-ribose 1-diphosphate + xanthine"}
{"X":14218,"RHEA_ID":10802,"DIRECTION":"RL","MASTER_ID":10800,"ecocyc":"XANPRIBOSYLTRAN-RXN","metacyc":"XANPRIBOSYLTRAN-RXN","compounds":"5-phospho-alpha-D-ribose 1-diphosphate + xanthine => diphosphate + XMP"}
{"X":14219,"RHEA_ID":20654,"compounds":"23,24-dihydrocucurbitacin B + NAD(+) => cucurbitacin B + H(+) + NADH"}
{"X":14220,"RHEA_ID":10804,"DIRECTION":"UN","MASTER_ID":10804,"ec":"5.1.99.3","compounds":"(S)-allantoin = (R)-allantoin"}
{"X":14221,"RHEA_ID":10805,"compounds":"(S)-allantoin => (R)-allantoin"}
{"X":14222,"RHEA_ID":10806,"compounds":"(R)-allantoin => (S)-allantoin"}
{"X":14223,"RHEA_ID":20658,"compounds":"4-chlorophenylacetonitrile + 2 H2O => 4-chlorophenylacetate + NH4(+)"}
{"X":14224,"RHEA_ID":10808,"DIRECTION":"UN","MASTER_ID":10808,"ec":"1.11.1.23","compounds":"(S)-2-hydroxypropylphosphonate + H2O2 = (1R,2S)-epoxypropylphosphonate + 2 H2O"}
{"X":14225,"RHEA_ID":10809,"DIRECTION":"LR","MASTER_ID":10808,"metacyc":"RXN-9011","compounds":"(S)-2-hydroxypropylphosphonate + H2O2 => (1R,2S)-epoxypropylphosphonate + 2 H2O"}
{"X":14226,"RHEA_ID":10810,"compounds":"(1R,2S)-epoxypropylphosphonate + 2 H2O => (S)-2-hydroxypropylphosphonate + H2O2"}
{"X":14227,"RHEA_ID":20662,"DIRECTION":"LR","MASTER_ID":20661,"ecocyc":"3.4.13.22-RXN","metacyc":"3.4.13.22-RXN","compounds":"D-alanyl-D-alanine + H2O => 2 D-alanine"}
{"X":14228,"RHEA_ID":10812,"DIRECTION":"UN","MASTER_ID":10812,"ec":"1.2.1.71","compounds":"H2O + N-succinyl-L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + N-succinyl-L-glutamate + NADH"}
{"X":14229,"RHEA_ID":10813,"compounds":"H2O + N-succinyl-L-glutamate 5-semialdehyde + NAD(+) => 2 H(+) + N-succinyl-L-glutamate + NADH"}
{"X":14230,"RHEA_ID":10814,"compounds":"2 H(+) + N-succinyl-L-glutamate + NADH => H2O + N-succinyl-L-glutamate 5-semialdehyde + NAD(+)"}
{"X":14231,"RHEA_ID":20666,"compounds":"1,5-anhydro-D-glucitol + NADP(+) => 1,5-anhydro-D-fructose + H(+) + NADPH"}
{"X":14232,"RHEA_ID":10816,"DIRECTION":"UN","MASTER_ID":10816,"ec":"3.2.1.63","compounds":"H2O + methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside = L-fucose + methyl beta-D-galactoside"}
{"X":14233,"RHEA_ID":10817,"DIRECTION":"LR","MASTER_ID":10816,"metacyc":"12-ALPHA-L-FUCOSIDASE-RXN","compounds":"H2O + methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside => L-fucose + methyl beta-D-galactoside"}
{"X":14234,"RHEA_ID":10818,"compounds":"L-fucose + methyl beta-D-galactoside => H2O + methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside"}
{"X":14235,"RHEA_ID":20670,"compounds":"3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate + NAD(+) => 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADH"}
{"X":14236,"RHEA_ID":10820,"DIRECTION":"UN","MASTER_ID":10820,"ec":"5.1.2.6","metacyc":"ISOCITRATE-EPIMERASE-RXN","compounds":"D-threo-isocitrate = D-erythro-isocitrate"}
{"X":14237,"RHEA_ID":10821,"compounds":"D-threo-isocitrate => D-erythro-isocitrate"}
{"X":14238,"RHEA_ID":10822,"compounds":"D-erythro-isocitrate => D-threo-isocitrate"}
{"X":14239,"RHEA_ID":20674,"compounds":"3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate + NADP(+) => 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADPH"}
{"X":14240,"RHEA_ID":10824,"DIRECTION":"UN","MASTER_ID":10824,"ec":"1.1.1.82","compounds":"(S)-malate + NADP(+) = H(+) + NADPH + oxaloacetate"}
{"X":14241,"RHEA_ID":10824,"DIRECTION":"UN","MASTER_ID":10824,"ec":"1.1.1.299","compounds":"(S)-malate + NADP(+) = H(+) + NADPH + oxaloacetate"}
{"X":14242,"RHEA_ID":10825,"compounds":"(S)-malate + NADP(+) => H(+) + NADPH + oxaloacetate"}
{"X":14243,"RHEA_ID":10826,"DIRECTION":"RL","MASTER_ID":10824,"metacyc":"MALATE-DEHYDROGENASE-NADP%2b-RXN","compounds":"H(+) + NADPH + oxaloacetate => (S)-malate + NADP(+)"}
{"X":14244,"RHEA_ID":20679,"compounds":"1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone + H(+) + UDP => alizarin + UDP-alpha-D-glucose"}
{"X":14245,"RHEA_ID":10828,"DIRECTION":"UN","MASTER_ID":10828,"ec":"6.2.1.32","compounds":"anthranilate + ATP + CoA = AMP + anthraniloyl-CoA + diphosphate"}
{"X":14246,"RHEA_ID":10829,"DIRECTION":"LR","MASTER_ID":10828,"metacyc":"AMINOBENZCOALIG-RXN","compounds":"anthranilate + ATP + CoA => AMP + anthraniloyl-CoA + diphosphate"}
{"X":14247,"RHEA_ID":10830,"compounds":"AMP + anthraniloyl-CoA + diphosphate => anthranilate + ATP + CoA"}
{"X":14248,"RHEA_ID":20683,"compounds":"H(+) + O-beta-D-glucosyl-cis-zeatin + UDP => cis-zeatin + UDP-alpha-D-glucose"}
{"X":14249,"RHEA_ID":10832,"DIRECTION":"UN","MASTER_ID":10832,"ec":"3.1.4.50","compounds":"a 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphate + H(+)"}
{"X":14250,"RHEA_ID":10833,"DIRECTION":"LR","MASTER_ID":10832,"metacyc":"GLYCOPROTEIN-PHOSPHOLIPASE-D-RXN","compounds":"a 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O => 6-(alpha-D-glucosaminyl)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphate + H(+)"}
{"X":14251,"RHEA_ID":10834,"compounds":"6-(alpha-D-glucosaminyl)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphate + H(+) => a 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O"}
{"X":14252,"RHEA_ID":10836,"DIRECTION":"UN","MASTER_ID":10836,"ec":"1.14.13.43","compounds":"NADPH + O2 + questin = demethylsulochrin + NADP(+)"}
{"X":14253,"RHEA_ID":10837,"DIRECTION":"LR","MASTER_ID":10836,"metacyc":"QUESTIN-MONOOXYGENASE-RXN","compounds":"NADPH + O2 + questin => demethylsulochrin + NADP(+)"}
{"X":14254,"RHEA_ID":10838,"compounds":"demethylsulochrin + NADP(+) => NADPH + O2 + questin"}
{"X":14255,"RHEA_ID":20691,"compounds":"(E)-caffeate + H(+) + L-quinate => chlorogenate + H2O"}
{"X":14256,"RHEA_ID":10840,"DIRECTION":"UN","MASTER_ID":10840,"ec":"4.2.3.1","compounds":"H2O + O-phospho-L-homoserine = L-threonine + phosphate"}
{"X":14257,"RHEA_ID":10841,"DIRECTION":"LR","MASTER_ID":10840,"ecocyc":"THRESYN-RXN","metacyc":"THRESYN-RXN","compounds":"H2O + O-phospho-L-homoserine => L-threonine + phosphate"}
{"X":14258,"RHEA_ID":10842,"compounds":"L-threonine + phosphate => H2O + O-phospho-L-homoserine"}
{"X":14259,"RHEA_ID":20697,"DIRECTION":"LR","MASTER_ID":20696,"ecocyc":"SUPEROX-DISMUT-RXN","macie":"M0138","metacyc":"SUPEROX-DISMUT-RXN","reactome":"R-HSA-1222469.1","compounds":"2 H(+) + 2 superoxide => H2O2 + O2"}
{"X":14260,"RHEA_ID":10844,"DIRECTION":"UN","MASTER_ID":10844,"ec":"2.6.1.31","compounds":"oxaloacetate + pyridoxamine = L-aspartate + pyridoxal"}
{"X":14261,"RHEA_ID":10845,"compounds":"oxaloacetate + pyridoxamine => L-aspartate + pyridoxal"}
{"X":14262,"RHEA_ID":10846,"compounds":"L-aspartate + pyridoxal => oxaloacetate + pyridoxamine"}
{"X":14263,"RHEA_ID":20697,"DIRECTION":"LR","MASTER_ID":20696,"ecocyc":"SUPEROX-DISMUT-RXN","macie":"M0138","metacyc":"SUPEROX-DISMUT-RXN","reactome":"R-HSA-3299680.1","compounds":"2 H(+) + 2 superoxide => H2O2 + O2"}
{"X":14264,"RHEA_ID":10848,"DIRECTION":"UN","MASTER_ID":10848,"ec":"7.4.2.7","compounds":"an [alpha-factor](in) + ATP + H2O = ADP + an [alpha-factor](out) + H(+) + phosphate"}
{"X":14265,"RHEA_ID":10849,"DIRECTION":"LR","MASTER_ID":10848,"metacyc":"3.6.3.48-RXN","compounds":"an [alpha-factor](in) + ATP + H2O => ADP + an [alpha-factor](out) + H(+) + phosphate"}
{"X":14266,"RHEA_ID":10850,"compounds":"ADP + an [alpha-factor](out) + H(+) + phosphate => an [alpha-factor](in) + ATP + H2O"}
{"X":14267,"RHEA_ID":10851,"compounds":"an [alpha-factor](in) + ATP + H2O <=> ADP + an [alpha-factor](out) + H(+) + phosphate"}
{"X":14268,"RHEA_ID":10852,"DIRECTION":"UN","MASTER_ID":10852,"ec":"2.5.1.71","compounds":"dimethylallyl diphosphate + leachianone G = diphosphate + sophoraflavanone G"}
{"X":14269,"RHEA_ID":10853,"DIRECTION":"LR","MASTER_ID":10852,"metacyc":"2.5.1.71-RXN","compounds":"dimethylallyl diphosphate + leachianone G => diphosphate + sophoraflavanone G"}
{"X":14270,"RHEA_ID":10854,"compounds":"diphosphate + sophoraflavanone G => dimethylallyl diphosphate + leachianone G"}
{"X":14271,"RHEA_ID":20705,"compounds":"a D-alpha-amino acid + acetyl-CoA => an N-acetyl-D-amino acid + CoA + H(+)"}
{"X":14272,"RHEA_ID":10856,"DIRECTION":"UN","MASTER_ID":10856,"ec":"2.4.1.47","compounds":"a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose = a 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + H(+) + UDP"}
{"X":14273,"RHEA_ID":10857,"DIRECTION":"LR","MASTER_ID":10856,"metacyc":"2.4.1.45-RXN","compounds":"a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose => a 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + H(+) + UDP"}
{"X":14274,"RHEA_ID":10858,"compounds":"a 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + H(+) + UDP => a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose"}
{"X":14275,"RHEA_ID":20709,"compounds":"ATP + erythritol => ADP + D-erythritol 4-phosphate + H(+)"}
{"X":14276,"RHEA_ID":10860,"DIRECTION":"UN","MASTER_ID":10860,"ec":"1.14.13.242","compounds":"3-hydroxy-2-methylpyridine-5-carboxylate + NADH + O2 = 2-(acetamidomethylene)succinate + NAD(+)"}
{"X":14277,"RHEA_ID":10861,"DIRECTION":"LR","MASTER_ID":10860,"metacyc":"1.14.12.4-RXN","compounds":"3-hydroxy-2-methylpyridine-5-carboxylate + NADH + O2 => 2-(acetamidomethylene)succinate + NAD(+)"}
{"X":14278,"RHEA_ID":10862,"compounds":"2-(acetamidomethylene)succinate + NAD(+) => 3-hydroxy-2-methylpyridine-5-carboxylate + NADH + O2"}
{"X":14279,"RHEA_ID":20713,"DIRECTION":"LR","MASTER_ID":20712,"ecocyc":"7KAPSYN-RXN","compounds":"6-carboxyhexanoyl-CoA + H(+) + L-alanine => 8-amino-7-oxononanoate + CO2 + CoA"}
{"X":14280,"RHEA_ID":10864,"DIRECTION":"UN","MASTER_ID":10864,"ec":"1.14.13.242","compounds":"3-hydroxy-2-methylpyridine-5-carboxylate + NADPH + O2 = 2-(acetamidomethylene)succinate + NADP(+)"}
{"X":14281,"RHEA_ID":10865,"DIRECTION":"LR","MASTER_ID":10864,"metacyc":"1.14.12.4-RXN","compounds":"3-hydroxy-2-methylpyridine-5-carboxylate + NADPH + O2 => 2-(acetamidomethylene)succinate + NADP(+)"}
{"X":14282,"RHEA_ID":10866,"compounds":"2-(acetamidomethylene)succinate + NADP(+) => 3-hydroxy-2-methylpyridine-5-carboxylate + NADPH + O2"}
{"X":14283,"RHEA_ID":20717,"compounds":"H(+) + H2O + S-adenosyl-L-homocysteine => NH4(+) + S-inosyl-L-homocysteine"}
{"X":14284,"RHEA_ID":10868,"DIRECTION":"UN","MASTER_ID":10868,"ec":"2.3.1.20","compounds":"a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA"}
{"X":14285,"RHEA_ID":10869,"DIRECTION":"LR","MASTER_ID":10868,"metacyc":"DIACYLGLYCEROL-O-ACYLTRANSFERASE-RXN","compounds":"a 1,2-diacyl-sn-glycerol + an acyl-CoA => a triacyl-sn-glycerol + CoA"}
{"X":14286,"RHEA_ID":10870,"compounds":"a triacyl-sn-glycerol + CoA => a 1,2-diacyl-sn-glycerol + an acyl-CoA"}
{"X":14287,"RHEA_ID":10872,"DIRECTION":"UN","MASTER_ID":10872,"ec":"3.5.1.15","compounds":"H2O + N-acyl-L-aspartate = a carboxylate + L-aspartate"}
{"X":14288,"RHEA_ID":10873,"DIRECTION":"LR","MASTER_ID":10872,"metacyc":"ASPARTOACYLASE-RXN","compounds":"H2O + N-acyl-L-aspartate => a carboxylate + L-aspartate"}
{"X":14289,"RHEA_ID":10874,"compounds":"a carboxylate + L-aspartate => H2O + N-acyl-L-aspartate"}
{"X":14290,"RHEA_ID":10876,"DIRECTION":"UN","MASTER_ID":10876,"ec":"4.1.1.61","compounds":"4-hydroxybenzoate + H(+) = CO2 + phenol"}
{"X":14291,"RHEA_ID":10877,"compounds":"4-hydroxybenzoate + H(+) => CO2 + phenol"}
{"X":14292,"RHEA_ID":10878,"compounds":"CO2 + phenol => 4-hydroxybenzoate + H(+)"}
{"X":14293,"RHEA_ID":10880,"DIRECTION":"UN","MASTER_ID":10880,"ec":"3.2.2.25","compounds":"7-methylxanthosine + H2O = 7-methylxanthine + D-ribose + H(+)"}
{"X":14294,"RHEA_ID":10881,"DIRECTION":"LR","MASTER_ID":10880,"metacyc":"RXN-7597","compounds":"7-methylxanthosine + H2O => 7-methylxanthine + D-ribose + H(+)"}
{"X":14295,"RHEA_ID":10882,"compounds":"7-methylxanthine + D-ribose + H(+) => 7-methylxanthosine + H2O"}
{"X":14296,"RHEA_ID":20733,"compounds":"[protein]-dithiol + [thioredoxin]-disulfide => [protein]-disulfide + [thioredoxin]-dithiol"}
{"X":14297,"RHEA_ID":10884,"DIRECTION":"UN","MASTER_ID":10884,"ec":"4.1.2.33","metacyc":"FUCOSTEROL-EPOXIDE-LYASE-RXN","compounds":"(24R,24(1)R)-fucosterol epoxide = acetaldehyde + cholesta-5,24-dien-3beta-ol"}
{"X":14298,"RHEA_ID":10885,"compounds":"(24R,24(1)R)-fucosterol epoxide => acetaldehyde + cholesta-5,24-dien-3beta-ol"}
{"X":14299,"RHEA_ID":10886,"compounds":"acetaldehyde + cholesta-5,24-dien-3beta-ol => (24R,24(1)R)-fucosterol epoxide"}
{"X":14300,"RHEA_ID":20737,"compounds":"acetyl-CoA + glycine => (2S)-2-amino-3-oxobutanoate + CoA"}
{"X":14301,"RHEA_ID":10888,"compounds":"4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + H2O + NADP(+) = 4-carboxy-2-hydroxy-cis,cis-muconate + 2 H(+) + NADPH"}
{"X":14302,"RHEA_ID":10889,"DIRECTION":"LR","MASTER_ID":10888,"metacyc":"1.2.1.45-RXN","compounds":"4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + H2O + NADP(+) => 4-carboxy-2-hydroxy-cis,cis-muconate + 2 H(+) + NADPH"}
{"X":14303,"RHEA_ID":10890,"compounds":"4-carboxy-2-hydroxy-cis,cis-muconate + 2 H(+) + NADPH => 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + H2O + NADP(+)"}
{"X":14304,"RHEA_ID":20741,"DIRECTION":"LR","MASTER_ID":20740,"metacyc":"TRANS-EPOXYSUCCINATE-HYDROLASE-RXN","compounds":"H2O + trans-2,3-epoxysuccinate => (2R,3S)-tartrate"}
{"X":14305,"RHEA_ID":10892,"compounds":"(2R,3S)-3-isopropylmalate + NAD(+) = (2S)-2-isopropyl-3-oxosuccinate + H(+) + NADH"}
{"X":14306,"RHEA_ID":10893,"compounds":"(2R,3S)-3-isopropylmalate + NAD(+) => (2S)-2-isopropyl-3-oxosuccinate + H(+) + NADH"}
{"X":14307,"RHEA_ID":10894,"compounds":"(2S)-2-isopropyl-3-oxosuccinate + H(+) + NADH => (2R,3S)-3-isopropylmalate + NAD(+)"}
{"X":14308,"RHEA_ID":20745,"compounds":"NADP(+) + prostaglandin D2 => 15-dehydro-prostaglandin D2 + H(+) + NADPH"}
{"X":14309,"RHEA_ID":10896,"DIRECTION":"UN","MASTER_ID":10896,"ec":"3.1.1.36","compounds":"2 H2O + limonin = 2 H(+) + limonoate"}
{"X":14310,"RHEA_ID":10897,"DIRECTION":"LR","MASTER_ID":10896,"metacyc":"LIMONIN-D-RING-LACTONASE-RXN","compounds":"2 H2O + limonin => 2 H(+) + limonoate"}
{"X":14311,"RHEA_ID":10898,"compounds":"2 H(+) + limonoate => 2 H2O + limonin"}
{"X":14312,"RHEA_ID":20749,"DIRECTION":"LR","MASTER_ID":20748,"macie":"M0137","metacyc":"1.14.20.1-RXN","compounds":"2-oxoglutarate + O2 + penicillin N => CO2 + deacetoxycephalosporin C + H2O + succinate"}
{"X":14313,"RHEA_ID":10900,"DIRECTION":"UN","MASTER_ID":10900,"ec":"2.6.1.60","compounds":"an aromatic L-alpha-amino acid + glyoxylate = an aromatic oxo-acid + glycine"}
{"X":14314,"RHEA_ID":10901,"compounds":"an aromatic L-alpha-amino acid + glyoxylate => an aromatic oxo-acid + glycine"}
{"X":14315,"RHEA_ID":10902,"compounds":"an aromatic oxo-acid + glycine => an aromatic L-alpha-amino acid + glyoxylate"}
{"X":14316,"RHEA_ID":10904,"DIRECTION":"UN","MASTER_ID":10904,"ec":"1.3.99.36","compounds":"[cypemycin](1-18)-L-Cys-L-Leu-L-Val-L-Cys + A = AH2 + C(3,19),S(21)-[cypemycin](1-18)-L-Ala-L-Leu-N-thioethenyl-L-valinamide + CO2 + hydrogen sulfide"}
{"X":14317,"RHEA_ID":10905,"compounds":"[cypemycin](1-18)-L-Cys-L-Leu-L-Val-L-Cys + A => AH2 + C(3,19),S(21)-[cypemycin](1-18)-L-Ala-L-Leu-N-thioethenyl-L-valinamide + CO2 + hydrogen sulfide"}
{"X":14318,"RHEA_ID":10906,"compounds":"AH2 + C(3,19),S(21)-[cypemycin](1-18)-L-Ala-L-Leu-N-thioethenyl-L-valinamide + CO2 + hydrogen sulfide => [cypemycin](1-18)-L-Cys-L-Leu-L-Val-L-Cys + A"}
{"X":14319,"RHEA_ID":10908,"DIRECTION":"UN","MASTER_ID":10908,"ec":"2.8.2.14","compounds":"3'-phosphoadenylyl sulfate + glycolithocholate = adenosine 3',5'-bisphosphate + H(+) + sulfoglycolithocholate"}
{"X":14320,"RHEA_ID":10909,"compounds":"3'-phosphoadenylyl sulfate + glycolithocholate => adenosine 3',5'-bisphosphate + H(+) + sulfoglycolithocholate"}
{"X":14321,"RHEA_ID":10910,"compounds":"adenosine 3',5'-bisphosphate + H(+) + sulfoglycolithocholate => 3'-phosphoadenylyl sulfate + glycolithocholate"}
{"X":14322,"RHEA_ID":20761,"compounds":"AH2 + linalool + O2 => (6E)-8-hydroxylinalool + A + H2O"}
{"X":14323,"RHEA_ID":10912,"DIRECTION":"UN","MASTER_ID":10912,"ec":"6.3.2.1","compounds":"(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+)"}
{"X":14324,"RHEA_ID":10913,"DIRECTION":"LR","MASTER_ID":10912,"ecocyc":"PANTOATE-BETA-ALANINE-LIG-RXN","metacyc":"PANTOATE-BETA-ALANINE-LIG-RXN","compounds":"(R)-pantoate + ATP + beta-alanine => (R)-pantothenate + AMP + diphosphate + H(+)"}
{"X":14325,"RHEA_ID":10914,"compounds":"(R)-pantothenate + AMP + diphosphate + H(+) => (R)-pantoate + ATP + beta-alanine"}
{"X":14326,"RHEA_ID":20765,"compounds":"(S)-methylmalonyl-CoA + pyruvate => oxaloacetate + propanoyl-CoA"}
{"X":14327,"RHEA_ID":10916,"compounds":"(1R,2R,3R)-prephytoene diphosphate = all-trans-phytoene + diphosphate"}
{"X":14328,"RHEA_ID":10917,"DIRECTION":"LR","MASTER_ID":10916,"metacyc":"RXN-12245","compounds":"(1R,2R,3R)-prephytoene diphosphate => all-trans-phytoene + diphosphate"}
{"X":14329,"RHEA_ID":10918,"compounds":"all-trans-phytoene + diphosphate => (1R,2R,3R)-prephytoene diphosphate"}
{"X":14330,"RHEA_ID":20769,"DIRECTION":"LR","MASTER_ID":20768,"metacyc":"4.1.1.82-RXN","compounds":"3-phosphonopyruvate + H(+) => CO2 + phosphonoacetaldehyde"}
{"X":14331,"RHEA_ID":10924,"DIRECTION":"UN","MASTER_ID":10924,"ec":"5.2.1.10","compounds":"cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide = trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide"}
{"X":14332,"RHEA_ID":10925,"compounds":"cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide => trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide"}
{"X":14333,"RHEA_ID":10926,"DIRECTION":"RL","MASTER_ID":10924,"metacyc":"5.2.1.10-RXN","compounds":"trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide => cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide"}
{"X":14334,"RHEA_ID":20773,"DIRECTION":"LR","MASTER_ID":20772,"ecocyc":"RIBOFLAVIN-SYN-RXN","macie":"M0247","metacyc":"RIBOFLAVIN-SYN-RXN","compounds":"2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) => 5-amino-6-(D-ribitylamino)uracil + riboflavin"}
{"X":14335,"RHEA_ID":10928,"compounds":"ent-kaur-16-en-19-al + O2 + reduced [NADPH--hemoprotein reductase] = ent-kaur-16-en-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":14336,"RHEA_ID":10929,"DIRECTION":"LR","MASTER_ID":10928,"metacyc":"RXN-7580","compounds":"ent-kaur-16-en-19-al + O2 + reduced [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":14337,"RHEA_ID":10930,"compounds":"ent-kaur-16-en-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-al + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":14338,"RHEA_ID":20777,"compounds":"alpha-D-galactosyl-(1->3)-1D-myo-inositol + raffinose => myo-inositol + stachyose"}
{"X":14339,"RHEA_ID":10932,"DIRECTION":"UN","MASTER_ID":10932,"ec":"6.3.4.5","compounds":"ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)"}
{"X":14340,"RHEA_ID":10933,"DIRECTION":"LR","MASTER_ID":10932,"ecocyc":"ARGSUCCINSYN-RXN","macie":"M0316","metacyc":"ARGSUCCINSYN-RXN","reactome":"R-HSA-70577.4","compounds":"ATP + L-aspartate + L-citrulline => 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)"}
{"X":14341,"RHEA_ID":10934,"compounds":"2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+) => ATP + L-aspartate + L-citrulline"}
{"X":14342,"RHEA_ID":20781,"compounds":"ATP + GMP => ADP + GDP"}
{"X":14343,"RHEA_ID":10936,"DIRECTION":"UN","MASTER_ID":10936,"ec":"1.8.5.2","compounds":"6-decylubiquinone + 2 thiosulfate = 6-decylubiquinol + tetrathionate"}
{"X":14344,"RHEA_ID":10937,"DIRECTION":"LR","MASTER_ID":10936,"metacyc":"1.8.5.2-RXN","compounds":"6-decylubiquinone + 2 thiosulfate => 6-decylubiquinol + tetrathionate"}
{"X":14345,"RHEA_ID":10938,"compounds":"6-decylubiquinol + tetrathionate => 6-decylubiquinone + 2 thiosulfate"}
{"X":14346,"RHEA_ID":20785,"DIRECTION":"LR","MASTER_ID":20784,"metacyc":"RXN-8732","compounds":"H2O + N(omega)-(ADP-D-ribosyl)-L-arginine => ADP-D-ribose + L-arginine"}
{"X":14347,"RHEA_ID":10940,"DIRECTION":"UN","MASTER_ID":10940,"ec":"4.2.3.20","compounds":"(2E)-geranyl diphosphate = (4R)-limonene + diphosphate"}
{"X":14348,"RHEA_ID":10941,"DIRECTION":"LR","MASTER_ID":10940,"metacyc":"4.2.3.20-RXN","compounds":"(2E)-geranyl diphosphate => (4R)-limonene + diphosphate"}
{"X":14349,"RHEA_ID":10942,"compounds":"(4R)-limonene + diphosphate => (2E)-geranyl diphosphate"}
{"X":14350,"RHEA_ID":20789,"compounds":"NAD(+) + phosphate => ADP-D-ribose 1''-phosphate + H(+) + nicotinamide"}
{"X":14351,"RHEA_ID":10944,"DIRECTION":"UN","MASTER_ID":10944,"ec":"3.1.3.96","compounds":"H2O + psi-UMP = phosphate + pseudouridine"}
{"X":14352,"RHEA_ID":10945,"DIRECTION":"LR","MASTER_ID":10944,"reactome":"R-HSA-6788295.1","compounds":"H2O + psi-UMP => phosphate + pseudouridine"}
{"X":14353,"RHEA_ID":10946,"compounds":"phosphate + pseudouridine => H2O + psi-UMP"}
{"X":14354,"RHEA_ID":10947,"DIRECTION":"BI","MASTER_ID":10944,"metacyc":"RXN-15703","compounds":"H2O + psi-UMP <=> phosphate + pseudouridine"}
{"X":14355,"RHEA_ID":10948,"DIRECTION":"UN","MASTER_ID":10948,"ec":"2.7.1.8","compounds":"ATP + D-glucosamine = ADP + D-glucosamine 6-phosphate + H(+)"}
{"X":14356,"RHEA_ID":10948,"DIRECTION":"UN","MASTER_ID":10948,"ec":"2.7.1.1","compounds":"ATP + D-glucosamine = ADP + D-glucosamine 6-phosphate + H(+)"}
{"X":14357,"RHEA_ID":10949,"compounds":"ATP + D-glucosamine => ADP + D-glucosamine 6-phosphate + H(+)"}
{"X":14358,"RHEA_ID":10950,"compounds":"ADP + D-glucosamine 6-phosphate + H(+) => ATP + D-glucosamine"}
{"X":14359,"RHEA_ID":20798,"compounds":"D-ribulose => aldehydo-D-ribose"}
{"X":14360,"RHEA_ID":10952,"DIRECTION":"UN","MASTER_ID":10952,"ec":"2.3.1.106","metacyc":"2.3.1.106-RXN","compounds":"hydroxymalonate + sinapoyl-CoA = CoA + sinapoyltartronate"}
{"X":14361,"RHEA_ID":10953,"compounds":"hydroxymalonate + sinapoyl-CoA => CoA + sinapoyltartronate"}
{"X":14362,"RHEA_ID":10954,"compounds":"CoA + sinapoyltartronate => hydroxymalonate + sinapoyl-CoA"}
{"X":14363,"RHEA_ID":20802,"compounds":"3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine"}
{"X":14364,"RHEA_ID":10956,"DIRECTION":"UN","MASTER_ID":10956,"ec":"1.14.13.14","compounds":"H(+) + NADPH + O2 + trans-cinnamate = H2O + NADP(+) + trans-2-coumarate"}
{"X":14365,"RHEA_ID":10957,"DIRECTION":"LR","MASTER_ID":10956,"metacyc":"TRANS-CINNAMATE-2-MONOOXYGENASE-RXN","compounds":"H(+) + NADPH + O2 + trans-cinnamate => H2O + NADP(+) + trans-2-coumarate"}
{"X":14366,"RHEA_ID":10958,"compounds":"H2O + NADP(+) + trans-2-coumarate => H(+) + NADPH + O2 + trans-cinnamate"}
{"X":14367,"RHEA_ID":20805,"DIRECTION":"LR","MASTER_ID":20804,"metacyc":"1.2.1.27-RXN","compounds":"2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) => H(+) + hydrogencarbonate + NADH + propanoyl-CoA"}
{"X":14368,"RHEA_ID":10960,"DIRECTION":"UN","MASTER_ID":10960,"ec":"5.1.2.1","compounds":"(S)-lactate = (R)-lactate"}
{"X":14369,"RHEA_ID":10961,"compounds":"(S)-lactate => (R)-lactate"}
{"X":14370,"RHEA_ID":10962,"compounds":"(R)-lactate => (S)-lactate"}
{"X":14371,"RHEA_ID":10964,"DIRECTION":"UN","MASTER_ID":10964,"ec":"2.7.1.17","compounds":"ATP + D-xylulose = ADP + D-xylulose 5-phosphate + H(+)"}
{"X":14372,"RHEA_ID":10965,"DIRECTION":"LR","MASTER_ID":10964,"ecocyc":"XYLULOKIN-RXN","metacyc":"XYLULOKIN-RXN","reactome":"R-HSA-5662466.2","compounds":"ATP + D-xylulose => ADP + D-xylulose 5-phosphate + H(+)"}
{"X":14373,"RHEA_ID":10966,"compounds":"ADP + D-xylulose 5-phosphate + H(+) => ATP + D-xylulose"}
{"X":14374,"RHEA_ID":20812,"DIRECTION":"UN","MASTER_ID":20812,"ec":"4.1.3.34","compounds":"(3S)-citryl-CoA = acetyl-CoA + oxaloacetate"}
{"X":14375,"RHEA_ID":10968,"DIRECTION":"UN","MASTER_ID":10968,"ec":"6.2.1.10","compounds":"a carboxylate + CoA + GTP = an acyl-CoA + GDP + phosphate"}
{"X":14376,"RHEA_ID":10969,"DIRECTION":"LR","MASTER_ID":10968,"metacyc":"ACID--COA-LIGASE-GDP-FORMING-RXN","compounds":"a carboxylate + CoA + GTP => an acyl-CoA + GDP + phosphate"}
{"X":14377,"RHEA_ID":10970,"compounds":"an acyl-CoA + GDP + phosphate => a carboxylate + CoA + GTP"}
{"X":14378,"RHEA_ID":20816,"DIRECTION":"UN","MASTER_ID":20816,"ec":"1.1.1.230","compounds":"3alpha-hydroxyglycyrrhetinate + NADP(+) = 3-oxoglycyrrhetinate + H(+) + NADPH"}
{"X":14379,"RHEA_ID":10972,"DIRECTION":"UN","MASTER_ID":10972,"ec":"2.7.1.62","metacyc":"2.7.1.62-RXN","compounds":"D-hexose + H(+) + phosphoramidate = alpha-D-hexose 1-phosphate + NH4(+)"}
{"X":14380,"RHEA_ID":10973,"compounds":"D-hexose + H(+) + phosphoramidate => alpha-D-hexose 1-phosphate + NH4(+)"}
{"X":14381,"RHEA_ID":10974,"compounds":"alpha-D-hexose 1-phosphate + NH4(+) => D-hexose + H(+) + phosphoramidate"}
{"X":14382,"RHEA_ID":20820,"DIRECTION":"UN","MASTER_ID":20820,"ec":"3.1.6.6","compounds":"choline sulfate + H2O = choline + H(+) + sulfate"}
{"X":14383,"RHEA_ID":10976,"DIRECTION":"UN","MASTER_ID":10976,"ec":"1.14.12.16","compounds":"H(+) + NADH + O2 + quinolin-2-ol = 5,6-dihydroquinoline-2,5,6-triol + NAD(+)"}
{"X":14384,"RHEA_ID":10977,"DIRECTION":"LR","MASTER_ID":10976,"metacyc":"1.14.12.16-RXN","compounds":"H(+) + NADH + O2 + quinolin-2-ol => 5,6-dihydroquinoline-2,5,6-triol + NAD(+)"}
{"X":14385,"RHEA_ID":10978,"compounds":"5,6-dihydroquinoline-2,5,6-triol + NAD(+) => H(+) + NADH + O2 + quinolin-2-ol"}
{"X":14386,"RHEA_ID":20824,"DIRECTION":"UN","MASTER_ID":20824,"ec":"2.7.1.20","compounds":"adenosine + ATP = ADP + AMP + H(+)"}
{"X":14387,"RHEA_ID":10980,"DIRECTION":"UN","MASTER_ID":10980,"ec":"5.1.1.18","compounds":"L-serine = D-serine"}
{"X":14388,"RHEA_ID":10981,"DIRECTION":"LR","MASTER_ID":10980,"metacyc":"5.1.1.18-RXN","reactome":"R-HSA-9014766.3","compounds":"L-serine => D-serine"}
{"X":14389,"RHEA_ID":10982,"compounds":"D-serine => L-serine"}
{"X":14390,"RHEA_ID":20828,"DIRECTION":"UN","MASTER_ID":20828,"ec":"4.1.1.65","compounds":"1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2"}
{"X":14391,"RHEA_ID":10984,"DIRECTION":"UN","MASTER_ID":10984,"ec":"1.1.99.7","compounds":"(S)-lactate + oxaloacetate = (S)-malate + pyruvate"}
{"X":14392,"RHEA_ID":10985,"compounds":"(S)-lactate + oxaloacetate => (S)-malate + pyruvate"}
{"X":14393,"RHEA_ID":10986,"compounds":"(S)-malate + pyruvate => (S)-lactate + oxaloacetate"}
{"X":14394,"RHEA_ID":20832,"DIRECTION":"UN","MASTER_ID":20832,"ec":"7.6.2.6","compounds":"ATP + guanine(out) + H2O = ADP + guanine(in) + H(+) + phosphate"}
{"X":14395,"RHEA_ID":10988,"compounds":"H2O + nitrous oxide = 2 e(-) + 2 H(+) + 2 nitric oxide"}
{"X":14396,"RHEA_ID":10989,"compounds":"H2O + nitrous oxide => 2 e(-) + 2 H(+) + 2 nitric oxide"}
{"X":14397,"RHEA_ID":10990,"compounds":"2 e(-) + 2 H(+) + 2 nitric oxide => H2O + nitrous oxide"}
{"X":14398,"RHEA_ID":10992,"DIRECTION":"UN","MASTER_ID":10992,"ec":"1.1.1.79","compounds":"glycolate + NADP(+) = glyoxylate + H(+) + NADPH"}
{"X":14399,"RHEA_ID":10993,"compounds":"glycolate + NADP(+) => glyoxylate + H(+) + NADPH"}
{"X":14400,"RHEA_ID":10994,"DIRECTION":"RL","MASTER_ID":10992,"ecocyc":"GLYOXYLATE-REDUCTASE-NADP%2b-RXN","metacyc":"GLYOXYLATE-REDUCTASE-NADP%2b-RXN","reactome":"R-HSA-389826.2","compounds":"glyoxylate + H(+) + NADPH => glycolate + NADP(+)"}
{"X":14401,"RHEA_ID":10996,"DIRECTION":"UN","MASTER_ID":10996,"ec":"2.1.1.91","compounds":"2-methylpropanal oxime + S-adenosyl-L-methionine = 2-methylpropanal O-methyloxime + H(+) + S-adenosyl-L-homocysteine"}
{"X":14402,"RHEA_ID":10997,"DIRECTION":"LR","MASTER_ID":10996,"metacyc":"ISOBUTYRALDOXIME-O-METHYLTRANSFERASE-RXN","compounds":"2-methylpropanal oxime + S-adenosyl-L-methionine => 2-methylpropanal O-methyloxime + H(+) + S-adenosyl-L-homocysteine"}
{"X":14403,"RHEA_ID":10998,"compounds":"2-methylpropanal O-methyloxime + H(+) + S-adenosyl-L-homocysteine => 2-methylpropanal oxime + S-adenosyl-L-methionine"}
{"X":14404,"RHEA_ID":20844,"DIRECTION":"UN","MASTER_ID":20844,"ec":"6.4.1.1","compounds":"ATP + hydrogencarbonate + pyruvate = ADP + H(+) + oxaloacetate + phosphate"}
{"X":14405,"RHEA_ID":11000,"DIRECTION":"UN","MASTER_ID":11000,"ec":"3.5.1.77","compounds":"an N-carbamoyl-D-amino acid + 2 H(+) + H2O = a D-alpha-amino acid + CO2 + NH4(+)"}
{"X":14406,"RHEA_ID":11001,"compounds":"an N-carbamoyl-D-amino acid + 2 H(+) + H2O => a D-alpha-amino acid + CO2 + NH4(+)"}
{"X":14407,"RHEA_ID":11002,"compounds":"a D-alpha-amino acid + CO2 + NH4(+) => an N-carbamoyl-D-amino acid + 2 H(+) + H2O"}
{"X":14408,"RHEA_ID":11004,"DIRECTION":"UN","MASTER_ID":11004,"ec":"1.14.13.1","compounds":"2 H(+) + NADH + O2 + salicylate = catechol + CO2 + H2O + NAD(+)"}
{"X":14409,"RHEA_ID":11005,"DIRECTION":"LR","MASTER_ID":11004,"metacyc":"SALICYLATE-1-MONOOXYGENASE-RXN","compounds":"2 H(+) + NADH + O2 + salicylate => catechol + CO2 + H2O + NAD(+)"}
{"X":14410,"RHEA_ID":11006,"compounds":"catechol + CO2 + H2O + NAD(+) => 2 H(+) + NADH + O2 + salicylate"}
{"X":14411,"RHEA_ID":20852,"DIRECTION":"UN","MASTER_ID":20852,"ec":"7.1.2.1","compounds":"ATP + H(+)(in) + H2O = ADP + 2 H(+)(out) + phosphate"}
{"X":14412,"RHEA_ID":11008,"DIRECTION":"UN","MASTER_ID":11008,"ec":"3.1.3.33","compounds":"a 5'-end triphospho-(purine-ribonucleotide) in mRNA + H2O = a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) + phosphate"}
{"X":14413,"RHEA_ID":11009,"DIRECTION":"LR","MASTER_ID":11008,"metacyc":"POLYNUCLEOTIDE-5-PHOSPHATASE-RXN","compounds":"a 5'-end triphospho-(purine-ribonucleotide) in mRNA + H2O => a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) + phosphate"}
{"X":14414,"RHEA_ID":11010,"compounds":"a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) + phosphate => a 5'-end triphospho-(purine-ribonucleotide) in mRNA + H2O"}
{"X":14415,"RHEA_ID":11011,"compounds":"a 5'-end triphospho-(purine-ribonucleotide) in mRNA + H2O <=> a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) + phosphate"}
{"X":14416,"RHEA_ID":11012,"DIRECTION":"UN","MASTER_ID":11012,"ec":"3.5.1.57","metacyc":"TRYPTOPHANAMIDASE-RXN","compounds":"H2O + L-tryptophanamide = L-tryptophan + NH4(+)"}
{"X":14417,"RHEA_ID":11013,"compounds":"H2O + L-tryptophanamide => L-tryptophan + NH4(+)"}
{"X":14418,"RHEA_ID":11014,"compounds":"L-tryptophan + NH4(+) => H2O + L-tryptophanamide"}
{"X":14419,"RHEA_ID":20860,"DIRECTION":"UN","MASTER_ID":20860,"ec":"1.1.1.223","compounds":"(1S,6R)-isopiperitenol + NAD(+) = (6R)-isopiperitenone + H(+) + NADH"}
{"X":14420,"RHEA_ID":11016,"DIRECTION":"UN","MASTER_ID":11016,"ec":"3.5.3.4","compounds":"allantoate + H2O = (S)-ureidoglycolate + urea"}
{"X":14421,"RHEA_ID":11017,"DIRECTION":"LR","MASTER_ID":11016,"metacyc":"ALLANTOICASE-RXN","compounds":"allantoate + H2O => (S)-ureidoglycolate + urea"}
{"X":14422,"RHEA_ID":11018,"compounds":"(S)-ureidoglycolate + urea => allantoate + H2O"}
{"X":14423,"RHEA_ID":20864,"DIRECTION":"UN","MASTER_ID":20864,"ec":"2.4.1.216","compounds":"alpha,alpha-trehalose 6-phosphate + phosphate = beta-D-glucose 1-phosphate + D-glucose 6-phosphate"}
{"X":14424,"RHEA_ID":11020,"DIRECTION":"UN","MASTER_ID":11020,"ec":"2.7.1.127","compounds":"1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)"}
{"X":14425,"RHEA_ID":11021,"DIRECTION":"LR","MASTER_ID":11020,"metacyc":"2.7.1.127-RXN","reactome":"R-HSA-1855233.2","compounds":"1D-myo-inositol 1,4,5-trisphosphate + ATP => 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)"}
{"X":14426,"RHEA_ID":11021,"DIRECTION":"LR","MASTER_ID":11020,"metacyc":"2.7.1.127-RXN","reactome":"R-HSA-1855153.2","compounds":"1D-myo-inositol 1,4,5-trisphosphate + ATP => 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)"}
{"X":14427,"RHEA_ID":11022,"compounds":"1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+) => 1D-myo-inositol 1,4,5-trisphosphate + ATP"}
{"X":14428,"RHEA_ID":20869,"compounds":"alpha,alpha-trehalose + H2O => 2 D-glucose"}
{"X":14429,"RHEA_ID":11024,"DIRECTION":"UN","MASTER_ID":11024,"ec":"2.7.3.8","metacyc":"AMMONIA-KINASE-RXN","compounds":"ATP + NH4(+) = ADP + 2 H(+) + phosphoramidate"}
{"X":14430,"RHEA_ID":11025,"compounds":"ATP + NH4(+) => ADP + 2 H(+) + phosphoramidate"}
{"X":14431,"RHEA_ID":11026,"compounds":"ADP + 2 H(+) + phosphoramidate => ATP + NH4(+)"}
{"X":14432,"RHEA_ID":20873,"DIRECTION":"LR","MASTER_ID":20872,"metacyc":"RXN-8887","compounds":"(20S)-ginsenoside Rd + UDP-alpha-D-glucose => (20S)-ginsenoside Rb1 + H(+) + UDP"}
{"X":14433,"RHEA_ID":11028,"DIRECTION":"UN","MASTER_ID":11028,"ec":"2.7.1.1","compounds":"ATP + D-mannose = ADP + D-mannose 6-phosphate + H(+)"}
{"X":14434,"RHEA_ID":11028,"DIRECTION":"UN","MASTER_ID":11028,"ec":"2.7.1.7","compounds":"ATP + D-mannose = ADP + D-mannose 6-phosphate + H(+)"}
{"X":14435,"RHEA_ID":11029,"DIRECTION":"LR","MASTER_ID":11028,"ecocyc":"MANNKIN-RXN","metacyc":"MANNKIN-RXN","compounds":"ATP + D-mannose => ADP + D-mannose 6-phosphate + H(+)"}
{"X":14436,"RHEA_ID":11030,"compounds":"ADP + D-mannose 6-phosphate + H(+) => ATP + D-mannose"}
{"X":14437,"RHEA_ID":20878,"compounds":"(E)-2-benzylidenesuccinyl-CoA + reduced [electron-transfer flavoprotein] => (R)-2-benzylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":14438,"RHEA_ID":11032,"DIRECTION":"UN","MASTER_ID":11032,"ec":"5.5.1.7","compounds":"(2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate + H(+)"}
{"X":14439,"RHEA_ID":11033,"compounds":"(2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate => 3-chloro-cis,cis-muconate + H(+)"}
{"X":14440,"RHEA_ID":11034,"compounds":"3-chloro-cis,cis-muconate + H(+) => (2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate"}
{"X":14441,"RHEA_ID":20882,"compounds":"10-oxodecanoate + H(+) + NADH => 10-hydroxydecanoate + NAD(+)"}
{"X":14442,"RHEA_ID":11036,"DIRECTION":"UN","MASTER_ID":11036,"ec":"7.6.2.9","compounds":"ATP + H2O + quaternary ammonium(out) = ADP + H(+) + phosphate + quaternary ammonium(in)"}
{"X":14443,"RHEA_ID":11037,"DIRECTION":"LR","MASTER_ID":11036,"metacyc":"3.6.3.32-RXN","compounds":"ATP + H2O + quaternary ammonium(out) => ADP + H(+) + phosphate + quaternary ammonium(in)"}
{"X":14444,"RHEA_ID":11038,"compounds":"ADP + H(+) + phosphate + quaternary ammonium(in) => ATP + H2O + quaternary ammonium(out)"}
{"X":14445,"RHEA_ID":11039,"compounds":"ATP + H2O + quaternary ammonium(out) <=> ADP + H(+) + phosphate + quaternary ammonium(in)"}
{"X":14446,"RHEA_ID":11040,"DIRECTION":"UN","MASTER_ID":11040,"ec":"4.2.1.19","compounds":"D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O"}
{"X":14447,"RHEA_ID":11041,"DIRECTION":"LR","MASTER_ID":11040,"ecocyc":"IMIDPHOSDEHYD-RXN","metacyc":"IMIDPHOSDEHYD-RXN","compounds":"D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate => 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O"}
{"X":14448,"RHEA_ID":11042,"compounds":"3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O => D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate"}
{"X":14449,"RHEA_ID":20890,"compounds":"3-hydroxy-2-methylpropanoate + CoA + H(+) => 3-hydroxy-2-methylpropanoyl-CoA + H2O"}
{"X":14450,"RHEA_ID":11044,"DIRECTION":"UN","MASTER_ID":11044,"ec":"3.8.1.3","compounds":"a haloacetate + H2O = a halide anion + glycolate + H(+)"}
{"X":14451,"RHEA_ID":11045,"compounds":"a haloacetate + H2O => a halide anion + glycolate + H(+)"}
{"X":14452,"RHEA_ID":11046,"compounds":"a halide anion + glycolate + H(+) => a haloacetate + H2O"}
{"X":14453,"RHEA_ID":11048,"DIRECTION":"UN","MASTER_ID":11048,"ec":"2.3.1.149","metacyc":"2.3.1.149-RXN","compounds":"1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + 1-organyl-2-lyso-sn-glycero-3-phospholipid = 1-O-alkyl-sn-glycero-3-phosphocholine + 1-organyl-2-acetyl-sn-glycero-3-phospholipid"}
{"X":14454,"RHEA_ID":11049,"compounds":"1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + 1-organyl-2-lyso-sn-glycero-3-phospholipid => 1-O-alkyl-sn-glycero-3-phosphocholine + 1-organyl-2-acetyl-sn-glycero-3-phospholipid"}
{"X":14455,"RHEA_ID":11050,"compounds":"1-O-alkyl-sn-glycero-3-phosphocholine + 1-organyl-2-acetyl-sn-glycero-3-phospholipid => 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + 1-organyl-2-lyso-sn-glycero-3-phospholipid"}
{"X":14456,"RHEA_ID":11052,"DIRECTION":"UN","MASTER_ID":11052,"ec":"1.14.13.27","compounds":"4-aminobenzoate + 2 H(+) + NADH + O2 = 4-aminophenol + CO2 + H2O + NAD(+)"}
{"X":14457,"RHEA_ID":11053,"DIRECTION":"LR","MASTER_ID":11052,"metacyc":"4-AMINOBENZOATE-1-MONOOXYGENASE-RXN","compounds":"4-aminobenzoate + 2 H(+) + NADH + O2 => 4-aminophenol + CO2 + H2O + NAD(+)"}
{"X":14458,"RHEA_ID":11054,"compounds":"4-aminophenol + CO2 + H2O + NAD(+) => 4-aminobenzoate + 2 H(+) + NADH + O2"}
{"X":14459,"RHEA_ID":20902,"compounds":"benzyl alcohol + CO2 + glycine => H(+) + H2O + N-benzyloxycarbonylglycine"}
{"X":14460,"RHEA_ID":11056,"DIRECTION":"UN","MASTER_ID":11056,"ec":"1.14.13.27","compounds":"4-aminobenzoate + 2 H(+) + NADPH + O2 = 4-aminophenol + CO2 + H2O + NADP(+)"}
{"X":14461,"RHEA_ID":11057,"DIRECTION":"LR","MASTER_ID":11056,"metacyc":"4-AMINOBENZOATE-1-MONOOXYGENASE-RXN","compounds":"4-aminobenzoate + 2 H(+) + NADPH + O2 => 4-aminophenol + CO2 + H2O + NADP(+)"}
{"X":14462,"RHEA_ID":11058,"compounds":"4-aminophenol + CO2 + H2O + NADP(+) => 4-aminobenzoate + 2 H(+) + NADPH + O2"}
{"X":14463,"RHEA_ID":20906,"DIRECTION":"RL","MASTER_ID":20904,"metacyc":"RXN-8805","compounds":"(S)-1,2-epoxypropane + coenzyme M => (2S)-2-hydroxypropyl-coenzyme M"}
{"X":14464,"RHEA_ID":11060,"DIRECTION":"UN","MASTER_ID":11060,"ec":"6.1.1.5","compounds":"ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)"}
{"X":14465,"RHEA_ID":11061,"DIRECTION":"LR","MASTER_ID":11060,"ecocyc":"ISOLEUCINE--TRNA-LIGASE-RXN","metacyc":"ISOLEUCINE--TRNA-LIGASE-RXN","compounds":"ATP + L-isoleucine + tRNA(Ile) => AMP + diphosphate + L-isoleucyl-tRNA(Ile)"}
{"X":14466,"RHEA_ID":11062,"compounds":"AMP + diphosphate + L-isoleucyl-tRNA(Ile) => ATP + L-isoleucine + tRNA(Ile)"}
{"X":14467,"RHEA_ID":20910,"compounds":"3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n+1)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP => 3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-alpha-D-glucuronate"}
{"X":14468,"RHEA_ID":11064,"DIRECTION":"UN","MASTER_ID":11064,"ec":"3.1.3.11","compounds":"beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate"}
{"X":14469,"RHEA_ID":11065,"DIRECTION":"LR","MASTER_ID":11064,"ecocyc":"F16BDEPHOS-RXN","metacyc":"F16BDEPHOS-RXN","compounds":"beta-D-fructose 1,6-bisphosphate + H2O => beta-D-fructose 6-phosphate + phosphate"}
{"X":14470,"RHEA_ID":11066,"compounds":"beta-D-fructose 6-phosphate + phosphate => beta-D-fructose 1,6-bisphosphate + H2O"}
{"X":14471,"RHEA_ID":20914,"compounds":"diphosphate + taxa-4,11-diene => all-trans-geranylgeranyl diphosphate"}
{"X":14472,"RHEA_ID":11068,"DIRECTION":"UN","MASTER_ID":11068,"ec":"3.2.1.107","compounds":"(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[procollagen] + H2O = (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[procollagen] + D-glucose"}
{"X":14473,"RHEA_ID":11069,"DIRECTION":"LR","MASTER_ID":11068,"metacyc":"3.2.1.107-RXN","compounds":"(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[procollagen] + H2O => (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[procollagen] + D-glucose"}
{"X":14474,"RHEA_ID":11070,"compounds":"(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[procollagen] + D-glucose => (5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[procollagen] + H2O"}
{"X":14475,"RHEA_ID":11072,"DIRECTION":"UN","MASTER_ID":11072,"ec":"1.14.12.1","compounds":"anthranilate + 3 H(+) + NADPH + O2 = catechol + CO2 + NADP(+) + NH4(+)"}
{"X":14476,"RHEA_ID":11073,"DIRECTION":"LR","MASTER_ID":11072,"metacyc":"1.14.12.1-RXN","compounds":"anthranilate + 3 H(+) + NADPH + O2 => catechol + CO2 + NADP(+) + NH4(+)"}
{"X":14477,"RHEA_ID":11074,"compounds":"catechol + CO2 + NADP(+) + NH4(+) => anthranilate + 3 H(+) + NADPH + O2"}
{"X":14478,"RHEA_ID":20922,"compounds":"3,5-dichlorocatechol + H2O + NADP(+) => 2,4-dichlorophenol + H(+) + NADPH + O2"}
{"X":14479,"RHEA_ID":11076,"DIRECTION":"UN","MASTER_ID":11076,"ec":"1.14.12.1","compounds":"anthranilate + 3 H(+) + NADH + O2 = catechol + CO2 + NAD(+) + NH4(+)"}
{"X":14480,"RHEA_ID":11077,"DIRECTION":"LR","MASTER_ID":11076,"metacyc":"1.14.12.1-RXN","compounds":"anthranilate + 3 H(+) + NADH + O2 => catechol + CO2 + NAD(+) + NH4(+)"}
{"X":14481,"RHEA_ID":11078,"compounds":"catechol + CO2 + NAD(+) + NH4(+) => anthranilate + 3 H(+) + NADH + O2"}
{"X":14482,"RHEA_ID":20926,"compounds":"a [peptide]-C-terminal amide + glyoxylate => a [peptide]-C-terminal (2S)-2-hydroxyglycine"}
{"X":14483,"RHEA_ID":11080,"DIRECTION":"UN","MASTER_ID":11080,"ec":"3.1.3.35","compounds":"dTMP + H2O = phosphate + thymidine"}
{"X":14484,"RHEA_ID":11081,"DIRECTION":"LR","MASTER_ID":11080,"metacyc":"THYMIDYLATE-5-PHOSPHATASE-RXN","compounds":"dTMP + H2O => phosphate + thymidine"}
{"X":14485,"RHEA_ID":11082,"compounds":"phosphate + thymidine => dTMP + H2O"}
{"X":14486,"RHEA_ID":20930,"compounds":"[DsbA protein]-disulfide + a quinol => [DsbA protein]-dithiol + a quinone"}
{"X":14487,"RHEA_ID":11084,"DIRECTION":"UN","MASTER_ID":11084,"ec":"4.1.1.34","compounds":"3-dehydro-L-gulonate + H(+) = CO2 + L-xylulose"}
{"X":14488,"RHEA_ID":11085,"DIRECTION":"LR","MASTER_ID":11084,"metacyc":"DEHYDRO-L-GULONATE-DECARBOXYLASE-RXN","reactome":"R-HSA-5662473.2","compounds":"3-dehydro-L-gulonate + H(+) => CO2 + L-xylulose"}
{"X":14489,"RHEA_ID":11086,"compounds":"CO2 + L-xylulose => 3-dehydro-L-gulonate + H(+)"}
{"X":14490,"RHEA_ID":20934,"compounds":"dihydroxyacetone phosphate + formaldehyde => L-erythrulose 1-phosphate"}
{"X":14491,"RHEA_ID":11088,"DIRECTION":"UN","MASTER_ID":11088,"ec":"3.6.1.2","metacyc":"TRIMETAPHOSPHATASE-RXN","compounds":"H2O + trimetaphosphate = 2 H(+) + triphosphate"}
{"X":14492,"RHEA_ID":11089,"compounds":"H2O + trimetaphosphate => 2 H(+) + triphosphate"}
{"X":14493,"RHEA_ID":11090,"compounds":"2 H(+) + triphosphate => H2O + trimetaphosphate"}
{"X":14494,"RHEA_ID":11092,"DIRECTION":"UN","MASTER_ID":11092,"ec":"1.1.1.8","compounds":"NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH"}
{"X":14495,"RHEA_ID":11092,"DIRECTION":"UN","MASTER_ID":11092,"ec":"1.1.1.94","compounds":"NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH"}
{"X":14496,"RHEA_ID":11093,"compounds":"NAD(+) + sn-glycerol 3-phosphate => dihydroxyacetone phosphate + H(+) + NADH"}
{"X":14497,"RHEA_ID":11094,"DIRECTION":"RL","MASTER_ID":11092,"ecocyc":"GLYC3PDEHYDROGBIOSYN-RXN","metacyc":"1.1.1.8-RXN","reactome":"R-HSA-75889.2","compounds":"dihydroxyacetone phosphate + H(+) + NADH => NAD(+) + sn-glycerol 3-phosphate"}
{"X":14498,"RHEA_ID":11094,"DIRECTION":"RL","MASTER_ID":11092,"ecocyc":"GLYC3PDEHYDROGBIOSYN-RXN","metacyc":"GLYC3PDEHYDROGBIOSYN-RXN","reactome":"R-HSA-75889.2","compounds":"dihydroxyacetone phosphate + H(+) + NADH => NAD(+) + sn-glycerol 3-phosphate"}
{"X":14499,"RHEA_ID":41474,"compounds":"H(+) + H2O + oryzalexin D + oxidized [NADPH--hemoprotein reductase] => ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":14500,"RHEA_ID":11096,"DIRECTION":"UN","MASTER_ID":11096,"ec":"1.1.1.94","compounds":"NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADPH"}
{"X":14501,"RHEA_ID":11097,"compounds":"NADP(+) + sn-glycerol 3-phosphate => dihydroxyacetone phosphate + H(+) + NADPH"}
{"X":14502,"RHEA_ID":11098,"DIRECTION":"RL","MASTER_ID":11096,"ecocyc":"GLYC3PDEHYDROGBIOSYN-RXN","metacyc":"GLYC3PDEHYDROGBIOSYN-RXN","compounds":"dihydroxyacetone phosphate + H(+) + NADPH => NADP(+) + sn-glycerol 3-phosphate"}
{"X":14503,"RHEA_ID":41478,"compounds":"CoA + zymosterol ester => 5alpha-cholesta-8,24-dien-3beta-ol + an acyl-CoA"}
{"X":14504,"RHEA_ID":11100,"DIRECTION":"UN","MASTER_ID":11100,"ec":"4.1.2.35","metacyc":"PROPIOIN-SYNTHASE-RXN","compounds":"4-hydroxyhexan-3-one = 2 propanal"}
{"X":14505,"RHEA_ID":11101,"compounds":"4-hydroxyhexan-3-one => 2 propanal"}
{"X":14506,"RHEA_ID":11102,"compounds":"2 propanal => 4-hydroxyhexan-3-one"}
{"X":14507,"RHEA_ID":11104,"compounds":"N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-methionine = H(+) + hercynine + S-adenosyl-L-homocysteine"}
{"X":14508,"RHEA_ID":11105,"DIRECTION":"LR","MASTER_ID":11104,"metacyc":"2.1.1.44-RXN","compounds":"N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-methionine => H(+) + hercynine + S-adenosyl-L-homocysteine"}
{"X":14509,"RHEA_ID":11106,"compounds":"H(+) + hercynine + S-adenosyl-L-homocysteine => N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-methionine"}
{"X":14510,"RHEA_ID":31509,"compounds":"H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate => aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine"}
{"X":14511,"RHEA_ID":11108,"DIRECTION":"UN","MASTER_ID":11108,"ec":"2.8.2.17","compounds":"n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate = n adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate + 2 H(+)"}
{"X":14512,"RHEA_ID":11109,"compounds":"n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate => n adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate + 2 H(+)"}
{"X":14513,"RHEA_ID":11110,"compounds":"n adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate + 2 H(+) => n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate"}
{"X":14514,"RHEA_ID":31513,"compounds":"chenodeoxycholate + CoA + H(+) => chenodeoxycholoyl-CoA + H2O"}
{"X":14515,"RHEA_ID":11112,"DIRECTION":"UN","MASTER_ID":11112,"ec":"3.3.2.1","compounds":"H2O + isochorismate = (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate"}
{"X":14516,"RHEA_ID":11113,"compounds":"H2O + isochorismate => (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate"}
{"X":14517,"RHEA_ID":11114,"compounds":"(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate => H2O + isochorismate"}
{"X":14518,"RHEA_ID":31517,"compounds":"2 H(+) + NADH + neurosporaxanthin => 4'-apo-beta-carotenal + H2O + NAD(+)"}
{"X":14519,"RHEA_ID":11116,"DIRECTION":"UN","MASTER_ID":11116,"ec":"2.3.1.57","compounds":"acetyl-CoA + an alkane-alpha,omega-diamine = an N-acetylalkane-alpha,omega-diamine + CoA + H(+)"}
{"X":14520,"RHEA_ID":11117,"DIRECTION":"LR","MASTER_ID":11116,"ecocyc":"DIAMACTRANS-RXN","metacyc":"DIAMACTRANS-RXN","compounds":"acetyl-CoA + an alkane-alpha,omega-diamine => an N-acetylalkane-alpha,omega-diamine + CoA + H(+)"}
{"X":14521,"RHEA_ID":11118,"compounds":"an N-acetylalkane-alpha,omega-diamine + CoA + H(+) => acetyl-CoA + an alkane-alpha,omega-diamine"}
{"X":14522,"RHEA_ID":31521,"compounds":"3-methyl-2-butenal + 4'-apo-beta-carotenal => O2 + torulene"}
{"X":14523,"RHEA_ID":11120,"DIRECTION":"UN","MASTER_ID":11120,"ec":"4.2.1.104","compounds":"cyanate + 3 H(+) + hydrogencarbonate = 2 CO2 + NH4(+)"}
{"X":14524,"RHEA_ID":11121,"DIRECTION":"LR","MASTER_ID":11120,"ecocyc":"RXN-12893","metacyc":"RXN-12893","compounds":"cyanate + 3 H(+) + hydrogencarbonate => 2 CO2 + NH4(+)"}
{"X":14525,"RHEA_ID":11122,"compounds":"2 CO2 + NH4(+) => cyanate + 3 H(+) + hydrogencarbonate"}
{"X":14526,"RHEA_ID":11128,"DIRECTION":"UN","MASTER_ID":11128,"ec":"2.3.1.74","compounds":"4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA = 2',4,4',6'-tetrahydroxychalcone + 3 CO2 + 4 CoA"}
{"X":14527,"RHEA_ID":11129,"DIRECTION":"LR","MASTER_ID":11128,"metacyc":"NARINGENIN-CHALCONE-SYNTHASE-RXN","compounds":"4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA => 2',4,4',6'-tetrahydroxychalcone + 3 CO2 + 4 CoA"}
{"X":14528,"RHEA_ID":11130,"compounds":"2',4,4',6'-tetrahydroxychalcone + 3 CO2 + 4 CoA => 4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA"}
{"X":14529,"RHEA_ID":11132,"DIRECTION":"UN","MASTER_ID":11132,"ec":"1.3.1.33","compounds":"chlorophyllide a + NADP(+) = H(+) + NADPH + protochlorophyllide a"}
{"X":14530,"RHEA_ID":11133,"compounds":"chlorophyllide a + NADP(+) => H(+) + NADPH + protochlorophyllide a"}
{"X":14531,"RHEA_ID":11134,"DIRECTION":"RL","MASTER_ID":11132,"metacyc":"RXN1F-10","compounds":"H(+) + NADPH + protochlorophyllide a => chlorophyllide a + NADP(+)"}
{"X":14532,"RHEA_ID":11136,"DIRECTION":"UN","MASTER_ID":11136,"ec":"2.4.99.3","compounds":"a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = a beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)"}
{"X":14533,"RHEA_ID":11137,"DIRECTION":"LR","MASTER_ID":11136,"metacyc":"RXN-15270","compounds":"a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate => a beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)"}
{"X":14534,"RHEA_ID":11138,"compounds":"a beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+) => a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate"}
{"X":14535,"RHEA_ID":11139,"compounds":"a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate <=> a beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)"}
{"X":14536,"RHEA_ID":11140,"DIRECTION":"UN","MASTER_ID":11140,"ec":"5.4.2.8","compounds":"alpha-D-mannose 1-phosphate = D-mannose 6-phosphate"}
{"X":14537,"RHEA_ID":11141,"compounds":"alpha-D-mannose 1-phosphate => D-mannose 6-phosphate"}
{"X":14538,"RHEA_ID":11142,"compounds":"D-mannose 6-phosphate => alpha-D-mannose 1-phosphate"}
{"X":14539,"RHEA_ID":11144,"DIRECTION":"UN","MASTER_ID":11144,"ec":"5.1.3.18","compounds":"GDP-alpha-D-mannose = GDP-beta-L-galactose"}
{"X":14540,"RHEA_ID":11145,"compounds":"GDP-alpha-D-mannose => GDP-beta-L-galactose"}
{"X":14541,"RHEA_ID":11146,"compounds":"GDP-beta-L-galactose => GDP-alpha-D-mannose"}
{"X":14542,"RHEA_ID":31545,"compounds":"2 H(+) + 2 UDP + zeaxanthin bis(beta-D-glucoside) => all-trans-zeaxanthin + 2 UDP-alpha-D-glucose"}
{"X":14543,"RHEA_ID":11148,"DIRECTION":"UN","MASTER_ID":11148,"ec":"1.16.3.1","compounds":"4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O"}
{"X":14544,"RHEA_ID":11149,"DIRECTION":"LR","MASTER_ID":11148,"ecocyc":"RXN0-1483","metacyc":"RXN0-1483","reactome":"R-HSA-1562603.1","compounds":"4 Fe(2+) + 4 H(+) + O2 => 4 Fe(3+) + 2 H2O"}
{"X":14545,"RHEA_ID":11149,"DIRECTION":"LR","MASTER_ID":11148,"ecocyc":"RXN0-1483","metacyc":"RXN0-1483","reactome":"R-HSA-1562604.1","compounds":"4 Fe(2+) + 4 H(+) + O2 => 4 Fe(3+) + 2 H2O"}
{"X":14546,"RHEA_ID":11149,"DIRECTION":"LR","MASTER_ID":11148,"ecocyc":"RXN0-1483","metacyc":"RXN0-1483","reactome":"R-HSA-917933.2","compounds":"4 Fe(2+) + 4 H(+) + O2 => 4 Fe(3+) + 2 H2O"}
{"X":14547,"RHEA_ID":11149,"DIRECTION":"LR","MASTER_ID":11148,"ecocyc":"RXN0-1483","metacyc":"RXN0-1483","reactome":"R-HSA-917891.2","compounds":"4 Fe(2+) + 4 H(+) + O2 => 4 Fe(3+) + 2 H2O"}
{"X":14548,"RHEA_ID":11150,"compounds":"4 Fe(3+) + 2 H2O => 4 Fe(2+) + 4 H(+) + O2"}
{"X":14549,"RHEA_ID":11152,"DIRECTION":"UN","MASTER_ID":11152,"ec":"1.14.13.241","compounds":"5-pyridoxate + NADPH + O2 = 2-(acetamidomethylene)-3-(hydroxymethyl)succinate + NADP(+)"}
{"X":14550,"RHEA_ID":11153,"DIRECTION":"LR","MASTER_ID":11152,"metacyc":"5-PYRIDOXATE-DIOXYGENASE-RXN","compounds":"5-pyridoxate + NADPH + O2 => 2-(acetamidomethylene)-3-(hydroxymethyl)succinate + NADP(+)"}
{"X":14551,"RHEA_ID":11154,"compounds":"2-(acetamidomethylene)-3-(hydroxymethyl)succinate + NADP(+) => 5-pyridoxate + NADPH + O2"}
{"X":14552,"RHEA_ID":21002,"compounds":"1,2,3,5-tetrahydroxybenzene + 1,3,5-trihydroxybenzene => 1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene"}
{"X":14553,"RHEA_ID":11156,"DIRECTION":"UN","MASTER_ID":11156,"ec":"1.4.1.8","metacyc":"VALINE-DEHYDROGENASE-NADP%252b-RXN","compounds":"H2O + L-valine + NADP(+) = 3-methyl-2-oxobutanoate + H(+) + NADPH + NH4(+)"}
{"X":14554,"RHEA_ID":11157,"compounds":"H2O + L-valine + NADP(+) => 3-methyl-2-oxobutanoate + H(+) + NADPH + NH4(+)"}
{"X":14555,"RHEA_ID":11158,"compounds":"3-methyl-2-oxobutanoate + H(+) + NADPH + NH4(+) => H2O + L-valine + NADP(+)"}
{"X":14556,"RHEA_ID":21006,"compounds":"2-dehydropantolactone + AH2 => (R)-pantolactone + A"}
{"X":14557,"RHEA_ID":11160,"DIRECTION":"UN","MASTER_ID":11160,"ec":"2.6.1.76","compounds":"2-oxoglutarate + L-2,4-diaminobutanoate = L-aspartate 4-semialdehyde + L-glutamate"}
{"X":14558,"RHEA_ID":11161,"compounds":"2-oxoglutarate + L-2,4-diaminobutanoate => L-aspartate 4-semialdehyde + L-glutamate"}
{"X":14559,"RHEA_ID":11162,"compounds":"L-aspartate 4-semialdehyde + L-glutamate => 2-oxoglutarate + L-2,4-diaminobutanoate"}
{"X":14560,"RHEA_ID":21010,"compounds":"diethyl 2-methyl-3-oxosuccinate + H(+) + NADPH => diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP(+)"}
{"X":14561,"RHEA_ID":11164,"DIRECTION":"UN","MASTER_ID":11164,"ec":"2.1.1.17","compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine"}
{"X":14562,"RHEA_ID":11165,"DIRECTION":"LR","MASTER_ID":11164,"metacyc":"2.1.1.17-RXN","compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine => 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine"}
{"X":14563,"RHEA_ID":11166,"compounds":"1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine"}
{"X":14564,"RHEA_ID":21014,"compounds":"4-O-([2-N-acetyl-alpha-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP => 4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine"}
{"X":14565,"RHEA_ID":11168,"DIRECTION":"UN","MASTER_ID":11168,"ec":"1.1.1.259","compounds":"3-hydroxy-6-carboxyhexanoyl-CoA + NAD(+) = 3-oxo-6-carboxyhexanoyl-CoA + H(+) + NADH"}
{"X":14566,"RHEA_ID":11169,"compounds":"3-hydroxy-6-carboxyhexanoyl-CoA + NAD(+) => 3-oxo-6-carboxyhexanoyl-CoA + H(+) + NADH"}
{"X":14567,"RHEA_ID":11170,"compounds":"3-oxo-6-carboxyhexanoyl-CoA + H(+) + NADH => 3-hydroxy-6-carboxyhexanoyl-CoA + NAD(+)"}
{"X":14568,"RHEA_ID":21016,"DIRECTION":"UN","MASTER_ID":21016,"ec":"3.5.1.1","compounds":"H2O + L-asparagine = L-aspartate + NH4(+)"}
{"X":14569,"RHEA_ID":11172,"DIRECTION":"UN","MASTER_ID":11172,"ec":"2.1.1.13","compounds":"(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine"}
{"X":14570,"RHEA_ID":11173,"DIRECTION":"LR","MASTER_ID":11172,"ecocyc":"HOMOCYSMETB12-RXN","macie":"M0268","metacyc":"HOMOCYSMETB12-RXN","compounds":"(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine => (6S)-5,6,7,8-tetrahydrofolate + L-methionine"}
{"X":14571,"RHEA_ID":11174,"compounds":"(6S)-5,6,7,8-tetrahydrofolate + L-methionine => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine"}
{"X":14572,"RHEA_ID":21020,"DIRECTION":"UN","MASTER_ID":21020,"ec":"4.2.3.5","compounds":"5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate"}
{"X":14573,"RHEA_ID":11176,"DIRECTION":"UN","MASTER_ID":11176,"ec":"2.4.1.230","compounds":"2-alpha-D-glucosyl-D-glucose + phosphate = beta-D-glucose 1-phosphate + D-glucose"}
{"X":14574,"RHEA_ID":11177,"compounds":"2-alpha-D-glucosyl-D-glucose + phosphate => beta-D-glucose 1-phosphate + D-glucose"}
{"X":14575,"RHEA_ID":11178,"compounds":"beta-D-glucose 1-phosphate + D-glucose => 2-alpha-D-glucosyl-D-glucose + phosphate"}
{"X":14576,"RHEA_ID":21024,"DIRECTION":"UN","MASTER_ID":21024,"ec":"1.2.1.17","compounds":"CoA + glyoxylate + NADP(+) = H(+) + NADPH + oxalyl-CoA"}
{"X":14577,"RHEA_ID":11180,"DIRECTION":"UN","MASTER_ID":11180,"ec":"6.1.1.22","compounds":"ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)"}
{"X":14578,"RHEA_ID":11181,"DIRECTION":"LR","MASTER_ID":11180,"ecocyc":"ASPARAGINE--TRNA-LIGASE-RXN","metacyc":"ASPARAGINE--TRNA-LIGASE-RXN","compounds":"ATP + L-asparagine + tRNA(Asn) => AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)"}
{"X":14579,"RHEA_ID":11182,"compounds":"AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn) => ATP + L-asparagine + tRNA(Asn)"}
{"X":14580,"RHEA_ID":21028,"compounds":"acetyl-CoA + an N-terminal L-alpha-aminoacyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-alpha-aminoacyl-[protein]"}
{"X":14581,"RHEA_ID":11184,"DIRECTION":"UN","MASTER_ID":11184,"ec":"3.5.1.6","compounds":"3-(carbamoylamino)propanoate + 2 H(+) + H2O = beta-alanine + CO2 + NH4(+)"}
{"X":14582,"RHEA_ID":11185,"DIRECTION":"LR","MASTER_ID":11184,"metacyc":"BETA-UREIDOPROPIONASE-RXN","reactome":"R-HSA-73591.3","compounds":"3-(carbamoylamino)propanoate + 2 H(+) + H2O => beta-alanine + CO2 + NH4(+)"}
{"X":14583,"RHEA_ID":11186,"compounds":"beta-alanine + CO2 + NH4(+) => 3-(carbamoylamino)propanoate + 2 H(+) + H2O"}
{"X":14584,"RHEA_ID":11188,"DIRECTION":"UN","MASTER_ID":11188,"ec":"3.5.5.4","compounds":"3-cyano-L-alanine + 2 H2O = L-aspartate + NH4(+)"}
{"X":14585,"RHEA_ID":11189,"DIRECTION":"LR","MASTER_ID":11188,"metacyc":"3.5.5.4-RXN","compounds":"3-cyano-L-alanine + 2 H2O => L-aspartate + NH4(+)"}
{"X":14586,"RHEA_ID":11190,"compounds":"L-aspartate + NH4(+) => 3-cyano-L-alanine + 2 H2O"}
{"X":14587,"RHEA_ID":21036,"DIRECTION":"UN","MASTER_ID":21036,"ec":"2.3.1.9","compounds":"2 acetyl-CoA = acetoacetyl-CoA + CoA"}
{"X":14588,"RHEA_ID":11192,"DIRECTION":"UN","MASTER_ID":11192,"ec":"3.8.1.2","compounds":"an (S)-2-haloacid + H2O = a (2R)-2-hydroxycarboxylate + a halide anion + H(+)"}
{"X":14589,"RHEA_ID":11192,"DIRECTION":"UN","MASTER_ID":11192,"ec":"3.8.1.10","compounds":"an (S)-2-haloacid + H2O = a (2R)-2-hydroxycarboxylate + a halide anion + H(+)"}
{"X":14590,"RHEA_ID":11193,"DIRECTION":"LR","MASTER_ID":11192,"metacyc":"2-HALOACID-DEHALOGENASE-RXN","compounds":"an (S)-2-haloacid + H2O => a (2R)-2-hydroxycarboxylate + a halide anion + H(+)"}
{"X":14591,"RHEA_ID":11194,"compounds":"a (2R)-2-hydroxycarboxylate + a halide anion + H(+) => an (S)-2-haloacid + H2O"}
{"X":14592,"RHEA_ID":11196,"DIRECTION":"UN","MASTER_ID":11196,"ec":"2.4.2.21","compounds":"5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate"}
{"X":14593,"RHEA_ID":11197,"DIRECTION":"LR","MASTER_ID":11196,"ecocyc":"DMBPPRIBOSYLTRANS-RXN","macie":"M0079","metacyc":"DMBPPRIBOSYLTRANS-RXN","compounds":"5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide => alpha-ribazole 5'-phosphate + H(+) + nicotinate"}
{"X":14594,"RHEA_ID":11198,"compounds":"alpha-ribazole 5'-phosphate + H(+) + nicotinate => 5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide"}
{"X":14595,"RHEA_ID":21044,"DIRECTION":"UN","MASTER_ID":21044,"ec":"2.1.1.143","compounds":"24-methylidenelophenol + S-adenosyl-L-methionine = (Z)-24-ethylidenelophenol + H(+) + S-adenosyl-L-homocysteine"}
{"X":14596,"RHEA_ID":11204,"DIRECTION":"UN","MASTER_ID":11204,"ec":"6.3.4.10","compounds":"apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin = AMP + diphosphate + H(+) + holo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)]"}
{"X":14597,"RHEA_ID":11205,"compounds":"apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin => AMP + diphosphate + H(+) + holo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)]"}
{"X":14598,"RHEA_ID":11206,"compounds":"AMP + diphosphate + H(+) + holo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] => apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin"}
{"X":14599,"RHEA_ID":21048,"compounds":"ATP + isopropylamine + L-glutamate = ADP + gamma-glutamyl-isopropylamide + H(+) + phosphate"}
{"X":14600,"RHEA_ID":11212,"DIRECTION":"UN","MASTER_ID":11212,"ec":"1.13.11.17","compounds":"indole + O2 = 2-formamidobenzaldehyde"}
{"X":14601,"RHEA_ID":11213,"DIRECTION":"LR","MASTER_ID":11212,"metacyc":"INDOLE-23-DIOXYGENASE-RXN","compounds":"indole + O2 => 2-formamidobenzaldehyde"}
{"X":14602,"RHEA_ID":11214,"compounds":"2-formamidobenzaldehyde => indole + O2"}
{"X":14603,"RHEA_ID":21052,"DIRECTION":"UN","MASTER_ID":21052,"ec":"1.1.1.269","compounds":"(2S)-2-hydroxypropyl-coenzyme M + NAD(+) = 2-oxopropyl-coenzyme M + H(+) + NADH"}
{"X":14604,"RHEA_ID":11216,"DIRECTION":"UN","MASTER_ID":11216,"ec":"2.7.4.13","compounds":"a 2'-deoxyribonucleoside 5'-phosphate + ATP = a 2'-deoxyribonucleoside 5'-diphosphate + ADP"}
{"X":14605,"RHEA_ID":11217,"DIRECTION":"LR","MASTER_ID":11216,"metacyc":"DEOXYNUCLEOSIDE-PHOSPHATE-KINASE-RXN","compounds":"a 2'-deoxyribonucleoside 5'-phosphate + ATP => a 2'-deoxyribonucleoside 5'-diphosphate + ADP"}
{"X":14606,"RHEA_ID":11218,"compounds":"a 2'-deoxyribonucleoside 5'-diphosphate + ADP => a 2'-deoxyribonucleoside 5'-phosphate + ATP"}
{"X":14607,"RHEA_ID":21056,"compounds":"lactoyl-CoA = acryloyl-CoA + H2O"}
{"X":14608,"RHEA_ID":11220,"DIRECTION":"UN","MASTER_ID":11220,"ec":"2.1.1.56","compounds":"a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + S-adenosyl-L-homocysteine"}
{"X":14609,"RHEA_ID":11221,"DIRECTION":"LR","MASTER_ID":11220,"metacyc":"2.1.1.57-RXN","compounds":"a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + S-adenosyl-L-homocysteine"}
{"X":14610,"RHEA_ID":11222,"compounds":"a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + S-adenosyl-L-homocysteine => a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + S-adenosyl-L-methionine"}
{"X":14611,"RHEA_ID":21060,"DIRECTION":"UN","MASTER_ID":21060,"ec":"2.3.1.114","metacyc":"2.3.1.114-RXN","compounds":"3,4-dichloroaniline + malonyl-CoA = CoA + N-(3,4-dichlorophenyl)malonamate"}
{"X":14612,"RHEA_ID":11224,"DIRECTION":"UN","MASTER_ID":11224,"ec":"6.3.2.4","compounds":"ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate"}
{"X":14613,"RHEA_ID":11225,"compounds":"ATP + 2 D-alanine => ADP + D-alanyl-D-alanine + H(+) + phosphate"}
{"X":14614,"RHEA_ID":11226,"compounds":"ADP + D-alanyl-D-alanine + H(+) + phosphate => ATP + 2 D-alanine"}
{"X":14615,"RHEA_ID":21064,"DIRECTION":"UN","MASTER_ID":21064,"ec":"1.8.4.2","compounds":"[protein]-disulfide + 2 glutathione = [protein]-dithiol + glutathione disulfide"}
{"X":14616,"RHEA_ID":11228,"DIRECTION":"UN","MASTER_ID":11228,"ec":"1.1.1.234","compounds":"(2S)-flavan-4-ol + NADP(+) = (2S)-flavanone + H(+) + NADPH"}
{"X":14617,"RHEA_ID":11229,"compounds":"(2S)-flavan-4-ol + NADP(+) => (2S)-flavanone + H(+) + NADPH"}
{"X":14618,"RHEA_ID":11230,"compounds":"(2S)-flavanone + H(+) + NADPH => (2S)-flavan-4-ol + NADP(+)"}
{"X":14619,"RHEA_ID":21068,"compounds":"A + H2O + nitrite = AH2 + nitrate"}
{"X":14620,"RHEA_ID":11232,"DIRECTION":"UN","MASTER_ID":11232,"ec":"3.6.2.2","compounds":"3'-phosphoadenylyl sulfate + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + sulfate"}
{"X":14621,"RHEA_ID":11233,"DIRECTION":"LR","MASTER_ID":11232,"metacyc":"PHOSPHOADENYLYLSULFATASE-RXN","compounds":"3'-phosphoadenylyl sulfate + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + sulfate"}
{"X":14622,"RHEA_ID":11234,"compounds":"adenosine 3',5'-bisphosphate + 2 H(+) + sulfate => 3'-phosphoadenylyl sulfate + H2O"}
{"X":14623,"RHEA_ID":21072,"DIRECTION":"UN","MASTER_ID":21072,"ec":"2.7.8.22","compounds":"1-O-(1Z)-alkenyl-2-acylglycerol + CDP-choline = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)"}
{"X":14624,"RHEA_ID":11236,"DIRECTION":"UN","MASTER_ID":11236,"ec":"2.5.1.44","compounds":"putrescine + spermidine = propane-1,3-diamine + sym-homospermidine"}
{"X":14625,"RHEA_ID":11236,"DIRECTION":"UN","MASTER_ID":11236,"ec":"2.5.1.45","compounds":"putrescine + spermidine = propane-1,3-diamine + sym-homospermidine"}
{"X":14626,"RHEA_ID":11237,"DIRECTION":"LR","MASTER_ID":11236,"metacyc":"2.5.1.45-RXN","compounds":"putrescine + spermidine => propane-1,3-diamine + sym-homospermidine"}
{"X":14627,"RHEA_ID":11238,"compounds":"propane-1,3-diamine + sym-homospermidine => putrescine + spermidine"}
{"X":14628,"RHEA_ID":21077,"DIRECTION":"LR","MASTER_ID":21076,"metacyc":"1.14.11.3-RXN","compounds":"2'-deoxyuridine + 2-oxoglutarate + O2 => CO2 + succinate + uridine"}
{"X":14629,"RHEA_ID":11240,"DIRECTION":"UN","MASTER_ID":11240,"ec":"2.7.4.15","compounds":"ATP + thiamine diphosphate = ADP + thiamine triphosphate"}
{"X":14630,"RHEA_ID":11241,"DIRECTION":"LR","MASTER_ID":11240,"metacyc":"THIAMIN-DIPHOSPHATE-KINASE-RXN","reactome":"R-HSA-997381.1","compounds":"ATP + thiamine diphosphate => ADP + thiamine triphosphate"}
{"X":14631,"RHEA_ID":11242,"compounds":"ADP + thiamine triphosphate => ATP + thiamine diphosphate"}
{"X":14632,"RHEA_ID":21081,"DIRECTION":"LR","MASTER_ID":21080,"ecocyc":"S-ADENMETSYN-RXN","macie":"M0009","metacyc":"S-ADENMETSYN-RXN","reactome":"R-HSA-174391.1","compounds":"ATP + H2O + L-methionine => diphosphate + phosphate + S-adenosyl-L-methionine"}
{"X":14633,"RHEA_ID":11248,"DIRECTION":"UN","MASTER_ID":11248,"ec":"3.1.1.75","compounds":"[(3R)-hydroxybutanoate](n) + H2O = (R)-3-hydroxybutanoate + [(3R)-hydroxybutanoate](n-1) + H(+)"}
{"X":14634,"RHEA_ID":11249,"DIRECTION":"LR","MASTER_ID":11248,"metacyc":"3.1.1.75-RXN","compounds":"[(3R)-hydroxybutanoate](n) + H2O => (R)-3-hydroxybutanoate + [(3R)-hydroxybutanoate](n-1) + H(+)"}
{"X":14635,"RHEA_ID":11250,"compounds":"(R)-3-hydroxybutanoate + [(3R)-hydroxybutanoate](n-1) + H(+) => [(3R)-hydroxybutanoate](n) + H2O"}
{"X":14636,"RHEA_ID":11252,"DIRECTION":"UN","MASTER_ID":11252,"ec":"2.3.2.7","metacyc":"ASPARTYLTRANSFERASE-RXN","compounds":"H(+) + hydroxylamine + L-asparagine = beta-L-aspartylhydroxamate + NH4(+)"}
{"X":14637,"RHEA_ID":11253,"compounds":"H(+) + hydroxylamine + L-asparagine => beta-L-aspartylhydroxamate + NH4(+)"}
{"X":14638,"RHEA_ID":11254,"compounds":"beta-L-aspartylhydroxamate + NH4(+) => H(+) + hydroxylamine + L-asparagine"}
{"X":14639,"RHEA_ID":21088,"DIRECTION":"UN","MASTER_ID":21088,"ec":"1.14.20.6","compounds":"2-oxoglutarate + a (2R,3R)-dihydroflavonol + O2 = a flavonol + CO2 + H2O + succinate"}
{"X":14640,"RHEA_ID":11256,"DIRECTION":"UN","MASTER_ID":11256,"ec":"2.4.1.210","compounds":"H2O + limonin + UDP-alpha-D-glucose = glucosyl-limonin + 2 H(+) + UDP"}
{"X":14641,"RHEA_ID":11257,"DIRECTION":"LR","MASTER_ID":11256,"metacyc":"2.4.1.210-RXN","compounds":"H2O + limonin + UDP-alpha-D-glucose => glucosyl-limonin + 2 H(+) + UDP"}
{"X":14642,"RHEA_ID":11258,"compounds":"glucosyl-limonin + 2 H(+) + UDP => H2O + limonin + UDP-alpha-D-glucose"}
{"X":14643,"RHEA_ID":21092,"DIRECTION":"UN","MASTER_ID":21092,"ec":"2.1.1.120","compounds":"12-hydroxydihydrochelirubine + S-adenosyl-L-methionine = dihydromacarpine + H(+) + S-adenosyl-L-homocysteine"}
{"X":14644,"RHEA_ID":11260,"DIRECTION":"UN","MASTER_ID":11260,"ec":"1.6.3.1","compounds":"H(+) + NADPH + O2 = H2O2 + NADP(+)"}
{"X":14645,"RHEA_ID":11261,"DIRECTION":"LR","MASTER_ID":11260,"metacyc":"RXN-10745","reactome":"R-HSA-5693681.1","compounds":"H(+) + NADPH + O2 => H2O2 + NADP(+)"}
{"X":14646,"RHEA_ID":11261,"DIRECTION":"LR","MASTER_ID":11260,"metacyc":"RXN-10745","reactome":"R-HSA-8865107.1","compounds":"H(+) + NADPH + O2 => H2O2 + NADP(+)"}
{"X":14647,"RHEA_ID":11262,"compounds":"H2O2 + NADP(+) => H(+) + NADPH + O2"}
{"X":14648,"RHEA_ID":11264,"DIRECTION":"UN","MASTER_ID":11264,"ec":"1.6.3.1","compounds":"H(+) + NADH + O2 = H2O2 + NAD(+)"}
{"X":14649,"RHEA_ID":11264,"DIRECTION":"UN","MASTER_ID":11264,"ec":"1.6.3.3","compounds":"H(+) + NADH + O2 = H2O2 + NAD(+)"}
{"X":14650,"RHEA_ID":11265,"DIRECTION":"LR","MASTER_ID":11264,"metacyc":"RXN-10745","compounds":"H(+) + NADH + O2 => H2O2 + NAD(+)"}
{"X":14651,"RHEA_ID":11266,"compounds":"H2O2 + NAD(+) => H(+) + NADH + O2"}
{"X":14652,"RHEA_ID":11268,"DIRECTION":"UN","MASTER_ID":11268,"ec":"4.4.1.15","compounds":"D-cysteine + H2O = H(+) + hydrogen sulfide + NH4(+) + pyruvate"}
{"X":14653,"RHEA_ID":11269,"compounds":"D-cysteine + H2O => H(+) + hydrogen sulfide + NH4(+) + pyruvate"}
{"X":14654,"RHEA_ID":11270,"compounds":"H(+) + hydrogen sulfide + NH4(+) + pyruvate => D-cysteine + H2O"}
{"X":14655,"RHEA_ID":11272,"DIRECTION":"UN","MASTER_ID":11272,"ec":"1.1.5.10","metacyc":"RXN-14931","compounds":"a (2R)-2-hydroxycarboxylate + a quinone = a 2-oxocarboxylate + a quinol"}
{"X":14656,"RHEA_ID":11273,"compounds":"a (2R)-2-hydroxycarboxylate + a quinone => a 2-oxocarboxylate + a quinol"}
{"X":14657,"RHEA_ID":11274,"compounds":"a 2-oxocarboxylate + a quinol => a (2R)-2-hydroxycarboxylate + a quinone"}
{"X":14658,"RHEA_ID":11276,"DIRECTION":"UN","MASTER_ID":11276,"ec":"1.10.3.2","compounds":"4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O"}
{"X":14659,"RHEA_ID":11277,"DIRECTION":"LR","MASTER_ID":11276,"metacyc":"LACCASE-RXN","compounds":"4 hydroquinone + O2 => 4 benzosemiquinone + 2 H2O"}
{"X":14660,"RHEA_ID":11278,"compounds":"4 benzosemiquinone + 2 H2O => 4 hydroquinone + O2"}
{"X":14661,"RHEA_ID":11280,"DIRECTION":"UN","MASTER_ID":11280,"ec":"2.1.2.8","compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP + H2O = (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dCMP"}
{"X":14662,"RHEA_ID":11281,"compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP + H2O => (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dCMP"}
{"X":14663,"RHEA_ID":11282,"compounds":"(6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dCMP => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP + H2O"}
{"X":14664,"RHEA_ID":21124,"compounds":"cytidine(72) in tRNA(Thr) + S-adenosyl-L-methionine = 5-methylcytidine(72) in tRNA(Thr) + H(+) + S-adenosyl-L-homocysteine"}
{"X":14665,"RHEA_ID":11284,"DIRECTION":"UN","MASTER_ID":11284,"ec":"1.1.1.167","metacyc":"HYDROXYMALONATE-DEHYDROGENASE-RXN","compounds":"hydroxymalonate + NAD(+) = H(+) + NADH + oxomalonate"}
{"X":14666,"RHEA_ID":11285,"compounds":"hydroxymalonate + NAD(+) => H(+) + NADH + oxomalonate"}
{"X":14667,"RHEA_ID":11286,"compounds":"H(+) + NADH + oxomalonate => hydroxymalonate + NAD(+)"}
{"X":14668,"RHEA_ID":21128,"DIRECTION":"UN","MASTER_ID":21128,"ec":"2.1.1.41","compounds":"5alpha-cholesta-8,24-dien-3beta-ol + S-adenosyl-L-methionine = 24-methylene-5alpha-cholest-8-en-3beta-ol + H(+) + S-adenosyl-L-homocysteine"}
{"X":14669,"RHEA_ID":11288,"DIRECTION":"UN","MASTER_ID":11288,"ec":"1.5.3.12","compounds":"dihydromacarpine + H(+) + O2 = H2O2 + macarpine"}
{"X":14670,"RHEA_ID":11289,"DIRECTION":"LR","MASTER_ID":11288,"metacyc":"RXN-8183","compounds":"dihydromacarpine + H(+) + O2 => H2O2 + macarpine"}
{"X":14671,"RHEA_ID":11290,"compounds":"H2O2 + macarpine => dihydromacarpine + H(+) + O2"}
{"X":14672,"RHEA_ID":11292,"DIRECTION":"UN","MASTER_ID":11292,"ec":"1.10.3.6","compounds":"2 H(+) + O2 + rifamycin B = H2O2 + rifamycin O"}
{"X":14673,"RHEA_ID":11293,"DIRECTION":"LR","MASTER_ID":11292,"metacyc":"RIFAMYCIN-B-OXIDASE-RXN","compounds":"2 H(+) + O2 + rifamycin B => H2O2 + rifamycin O"}
{"X":14674,"RHEA_ID":11294,"compounds":"H2O2 + rifamycin O => 2 H(+) + O2 + rifamycin B"}
{"X":14675,"RHEA_ID":21136,"DIRECTION":"UN","MASTER_ID":21136,"ec":"2.3.1.7","compounds":"(R)-carnitine + acetyl-CoA = CoA + O-acetyl-(R)-carnitine"}
{"X":14676,"RHEA_ID":11296,"DIRECTION":"UN","MASTER_ID":11296,"ec":"1.2.1.26","compounds":"2,5-dioxopentanoate + H2O + NADP(+) = 2-oxoglutarate + 2 H(+) + NADPH"}
{"X":14677,"RHEA_ID":11297,"DIRECTION":"LR","MASTER_ID":11296,"metacyc":"25-DIOXOVALERATE-DEHYDROGENASE-RXN","compounds":"2,5-dioxopentanoate + H2O + NADP(+) => 2-oxoglutarate + 2 H(+) + NADPH"}
{"X":14678,"RHEA_ID":11298,"compounds":"2-oxoglutarate + 2 H(+) + NADPH => 2,5-dioxopentanoate + H2O + NADP(+)"}
{"X":14679,"RHEA_ID":21140,"DIRECTION":"UN","MASTER_ID":21140,"ec":"2.7.1.73","compounds":"ATP + inosine = ADP + H(+) + IMP"}
{"X":14680,"RHEA_ID":11300,"DIRECTION":"UN","MASTER_ID":11300,"ec":"1.1.1.143","compounds":"1D-5-O-methyl-myo-inositol + NAD(+) = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADH"}
{"X":14681,"RHEA_ID":11301,"compounds":"1D-5-O-methyl-myo-inositol + NAD(+) => 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADH"}
{"X":14682,"RHEA_ID":11302,"compounds":"2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADH => 1D-5-O-methyl-myo-inositol + NAD(+)"}
{"X":14683,"RHEA_ID":21144,"DIRECTION":"UN","MASTER_ID":21144,"ec":"1.5.98.2","compounds":"5-methyl-5,6,7,8-tetrahydromethanopterin + H(+) + oxidized coenzyme F420-(gamma-Glu)(n) = 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420-(gamma-Glu)(n)"}
{"X":14684,"RHEA_ID":11304,"DIRECTION":"UN","MASTER_ID":11304,"ec":"4.3.2.3","compounds":"(S)-ureidoglycolate = glyoxylate + urea"}
{"X":14685,"RHEA_ID":11305,"DIRECTION":"LR","MASTER_ID":11304,"ecocyc":"UREIDOGLYCOLATE-LYASE-RXN","metacyc":"UREIDOGLYCOLATE-LYASE-RXN","compounds":"(S)-ureidoglycolate => glyoxylate + urea"}
{"X":14686,"RHEA_ID":11306,"compounds":"glyoxylate + urea => (S)-ureidoglycolate"}
{"X":14687,"RHEA_ID":11308,"DIRECTION":"UN","MASTER_ID":11308,"ec":"6.4.1.2","compounds":"acetyl-CoA + ATP + hydrogencarbonate = ADP + H(+) + malonyl-CoA + phosphate"}
{"X":14688,"RHEA_ID":11309,"DIRECTION":"LR","MASTER_ID":11308,"ecocyc":"ACETYL-COA-CARBOXYLTRANSFER-RXN","metacyc":"ACETYL-COA-CARBOXYLTRANSFER-RXN","reactome":"R-HSA-75851.4","compounds":"acetyl-CoA + ATP + hydrogencarbonate => ADP + H(+) + malonyl-CoA + phosphate"}
{"X":14689,"RHEA_ID":11309,"DIRECTION":"LR","MASTER_ID":11308,"ecocyc":"ACETYL-COA-CARBOXYLTRANSFER-RXN","metacyc":"ACETYL-COA-CARBOXYLTRANSFER-RXN","reactome":"R-HSA-200555.4","compounds":"acetyl-CoA + ATP + hydrogencarbonate => ADP + H(+) + malonyl-CoA + phosphate"}
{"X":14690,"RHEA_ID":11309,"DIRECTION":"LR","MASTER_ID":11308,"ecocyc":"ACETYL-COA-CARBOXYLTRANSFER-RXN","metacyc":"ACETYL-COA-CARBOXYLTRANSFER-RXN","reactome":"R-HSA-8876889.3","compounds":"acetyl-CoA + ATP + hydrogencarbonate => ADP + H(+) + malonyl-CoA + phosphate"}
{"X":14691,"RHEA_ID":11310,"compounds":"ADP + H(+) + malonyl-CoA + phosphate => acetyl-CoA + ATP + hydrogencarbonate"}
{"X":14692,"RHEA_ID":21154,"compounds":"cis-4-hydroxy-D-proline => trans-4-hydroxy-L-proline"}
{"X":14693,"RHEA_ID":11312,"DIRECTION":"UN","MASTER_ID":11312,"ec":"3.8.1.8","compounds":"atrazine + H2O = chloride + H(+) + hydroxyatrazine"}
{"X":14694,"RHEA_ID":11313,"DIRECTION":"LR","MASTER_ID":11312,"metacyc":"3.8.1.8-RXN","compounds":"atrazine + H2O => chloride + H(+) + hydroxyatrazine"}
{"X":14695,"RHEA_ID":11314,"compounds":"chloride + H(+) + hydroxyatrazine => atrazine + H2O"}
{"X":14696,"RHEA_ID":21158,"compounds":"(R)-glycerate + phosphate => (2R)-2-phosphoglycerate + H2O"}
{"X":14697,"RHEA_ID":11316,"DIRECTION":"UN","MASTER_ID":11316,"ec":"4.99.1.5","compounds":"an aliphatic aldoxime = a nitrile + H2O"}
{"X":14698,"RHEA_ID":11317,"DIRECTION":"LR","MASTER_ID":11316,"metacyc":"4.99.1.5-RXN","compounds":"an aliphatic aldoxime => a nitrile + H2O"}
{"X":14699,"RHEA_ID":11318,"compounds":"a nitrile + H2O => an aliphatic aldoxime"}
{"X":14700,"RHEA_ID":11320,"DIRECTION":"UN","MASTER_ID":11320,"ec":"5.1.3.5","compounds":"UDP-beta-L-arabinopyranose = UDP-alpha-D-xylose"}
{"X":14701,"RHEA_ID":11321,"compounds":"UDP-beta-L-arabinopyranose => UDP-alpha-D-xylose"}
{"X":14702,"RHEA_ID":11322,"compounds":"UDP-alpha-D-xylose => UDP-beta-L-arabinopyranose"}
{"X":14703,"RHEA_ID":21166,"compounds":"a carboxylate + an alcohol + H(+) => a carboxylic ester + H2O"}
{"X":14704,"RHEA_ID":11324,"compounds":"all-trans-octaprenyl diphosphate + isopentenyl diphosphate = all-trans-nonaprenyl diphosphate + diphosphate"}
{"X":14705,"RHEA_ID":11325,"DIRECTION":"LR","MASTER_ID":11324,"metacyc":"TRANS-OCTAPRENYLTRANSTRANSFERASE-RXN","compounds":"all-trans-octaprenyl diphosphate + isopentenyl diphosphate => all-trans-nonaprenyl diphosphate + diphosphate"}
{"X":14706,"RHEA_ID":11326,"compounds":"all-trans-nonaprenyl diphosphate + diphosphate => all-trans-octaprenyl diphosphate + isopentenyl diphosphate"}
{"X":14707,"RHEA_ID":21170,"compounds":"(6R)-L-erythro-6,7-dihydrobiopterin + 3-hydroxyanthranilate + H2O => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + anthranilate + O2"}
{"X":14708,"RHEA_ID":11328,"DIRECTION":"UN","MASTER_ID":11328,"ec":"2.5.1.28","compounds":"dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + neryl diphosphate"}
{"X":14709,"RHEA_ID":11329,"DIRECTION":"LR","MASTER_ID":11328,"metacyc":"DIMETHYLALLYLCISTRANSFERASE-RXN","compounds":"dimethylallyl diphosphate + isopentenyl diphosphate => diphosphate + neryl diphosphate"}
{"X":14710,"RHEA_ID":11330,"compounds":"diphosphate + neryl diphosphate => dimethylallyl diphosphate + isopentenyl diphosphate"}
{"X":14711,"RHEA_ID":21173,"DIRECTION":"LR","MASTER_ID":21172,"ecocyc":"1.1.1.264-RXN","metacyc":"RXN-12107","compounds":"L-idonate + NAD(+) => 5-dehydro-D-gluconate + H(+) + NADH"}
{"X":14712,"RHEA_ID":11332,"DIRECTION":"UN","MASTER_ID":11332,"ec":"2.7.7.19","compounds":"ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide"}
{"X":14713,"RHEA_ID":11333,"DIRECTION":"LR","MASTER_ID":11332,"ecocyc":"POLYNUCLEOTIDE-ADENYLYLTRANSFERASE-RXN","metacyc":"POLYNUCLEOTIDE-ADENYLYLTRANSFERASE-RXN","compounds":"ATP + RNA(n) => diphosphate + RNA(n)-3'-adenine ribonucleotide"}
{"X":14714,"RHEA_ID":11334,"compounds":"diphosphate + RNA(n)-3'-adenine ribonucleotide => ATP + RNA(n)"}
{"X":14715,"RHEA_ID":11336,"DIRECTION":"UN","MASTER_ID":11336,"ec":"2.1.1.99","compounds":"(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine = deacetoxyvindoline + H(+) + S-adenosyl-L-homocysteine"}
{"X":14716,"RHEA_ID":11337,"DIRECTION":"LR","MASTER_ID":11336,"metacyc":"2.1.1.99-RXN","compounds":"(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine => deacetoxyvindoline + H(+) + S-adenosyl-L-homocysteine"}
{"X":14717,"RHEA_ID":11338,"compounds":"deacetoxyvindoline + H(+) + S-adenosyl-L-homocysteine => (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine"}
{"X":14718,"RHEA_ID":31733,"compounds":"3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H(+) + H2O => 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2"}
{"X":14719,"RHEA_ID":11340,"DIRECTION":"UN","MASTER_ID":11340,"ec":"4.1.1.75","compounds":"5-guanidino-2-oxopentanoate + H(+) = 4-guanidinobutanal + CO2"}
{"X":14720,"RHEA_ID":11341,"DIRECTION":"LR","MASTER_ID":11340,"metacyc":"4.1.1.75-RXN","compounds":"5-guanidino-2-oxopentanoate + H(+) => 4-guanidinobutanal + CO2"}
{"X":14721,"RHEA_ID":11342,"compounds":"4-guanidinobutanal + CO2 => 5-guanidino-2-oxopentanoate + H(+)"}
{"X":14722,"RHEA_ID":31737,"DIRECTION":"RL","MASTER_ID":31735,"metacyc":"RXN-17403","compounds":"3-oxochol-4-en-24-oyl-CoA + H(+) + NADH => 3-oxocholan-24-oyl-CoA + NAD(+)"}
{"X":14723,"RHEA_ID":11344,"DIRECTION":"UN","MASTER_ID":11344,"ec":"2.7.7.43","compounds":"an N-acylneuraminate + CTP = a CMP-N-acyl-beta-neuraminate + diphosphate"}
{"X":14724,"RHEA_ID":11345,"compounds":"an N-acylneuraminate + CTP => a CMP-N-acyl-beta-neuraminate + diphosphate"}
{"X":14725,"RHEA_ID":11346,"compounds":"a CMP-N-acyl-beta-neuraminate + diphosphate => an N-acylneuraminate + CTP"}
{"X":14726,"RHEA_ID":11348,"DIRECTION":"UN","MASTER_ID":11348,"ec":"7.3.2.7","compounds":"arsenite(in) + ATP + H2O = ADP + arsenite(out) + H(+) + phosphate"}
{"X":14727,"RHEA_ID":11349,"DIRECTION":"LR","MASTER_ID":11348,"metacyc":"3.6.3.16-RXN","compounds":"arsenite(in) + ATP + H2O => ADP + arsenite(out) + H(+) + phosphate"}
{"X":14728,"RHEA_ID":11350,"compounds":"ADP + arsenite(out) + H(+) + phosphate => arsenite(in) + ATP + H2O"}
{"X":14729,"RHEA_ID":11351,"compounds":"arsenite(in) + ATP + H2O <=> ADP + arsenite(out) + H(+) + phosphate"}
{"X":14730,"RHEA_ID":11352,"DIRECTION":"UN","MASTER_ID":11352,"ec":"2.7.2.1","compounds":"acetate + ATP = acetyl phosphate + ADP"}
{"X":14731,"RHEA_ID":11353,"compounds":"acetate + ATP => acetyl phosphate + ADP"}
{"X":14732,"RHEA_ID":11354,"compounds":"acetyl phosphate + ADP => acetate + ATP"}
{"X":14733,"RHEA_ID":21196,"DIRECTION":"UN","MASTER_ID":21196,"ec":"2.1.1.14","compounds":"5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate"}
{"X":14734,"RHEA_ID":11356,"DIRECTION":"UN","MASTER_ID":11356,"ec":"1.6.99.3","compounds":"A + H(+) + NADH = AH2 + NAD(+)"}
{"X":14735,"RHEA_ID":11357,"DIRECTION":"LR","MASTER_ID":11356,"ecocyc":"NQOR-RXN","metacyc":"NQOR-RXN","compounds":"A + H(+) + NADH => AH2 + NAD(+)"}
{"X":14736,"RHEA_ID":11358,"compounds":"AH2 + NAD(+) => A + H(+) + NADH"}
{"X":14737,"RHEA_ID":11360,"compounds":"2 2',3,4,4',6'-pentahydroxychalcone + 2 H(+) + O2 = 2 aureusidin + 2 H2O"}
{"X":14738,"RHEA_ID":11361,"DIRECTION":"LR","MASTER_ID":11360,"metacyc":"RXN-3102","compounds":"2 2',3,4,4',6'-pentahydroxychalcone + 2 H(+) + O2 => 2 aureusidin + 2 H2O"}
{"X":14739,"RHEA_ID":11362,"compounds":"2 aureusidin + 2 H2O => 2 2',3,4,4',6'-pentahydroxychalcone + 2 H(+) + O2"}
{"X":14740,"RHEA_ID":21204,"DIRECTION":"UN","MASTER_ID":21204,"ec":"2.3.1.43","compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + a sterol = a 1-acyl-sn-glycero-3-phosphocholine + a sterol ester"}
{"X":14741,"RHEA_ID":11364,"DIRECTION":"UN","MASTER_ID":11364,"ec":"2.7.9.2","compounds":"ATP + H2O + pyruvate = AMP + 2 H(+) + phosphate + phosphoenolpyruvate"}
{"X":14742,"RHEA_ID":11365,"DIRECTION":"LR","MASTER_ID":11364,"ecocyc":"PEPSYNTH-RXN","metacyc":"PEPSYNTH-RXN","compounds":"ATP + H2O + pyruvate => AMP + 2 H(+) + phosphate + phosphoenolpyruvate"}
{"X":14743,"RHEA_ID":11366,"compounds":"AMP + 2 H(+) + phosphate + phosphoenolpyruvate => ATP + H2O + pyruvate"}
{"X":14744,"RHEA_ID":21208,"DIRECTION":"UN","MASTER_ID":21208,"ec":"3.1.3.3","compounds":"H2O + O-phospho-L-serine = L-serine + phosphate"}
{"X":14745,"RHEA_ID":11368,"compounds":"1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H(+) + NADH + O2 = 1-acyl-2-[(S)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + H2O + NAD(+)"}
{"X":14746,"RHEA_ID":11369,"compounds":"1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H(+) + NADH + O2 => 1-acyl-2-[(S)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + H2O + NAD(+)"}
{"X":14747,"RHEA_ID":11370,"compounds":"1-acyl-2-[(S)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + H2O + NAD(+) => 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H(+) + NADH + O2"}
{"X":14748,"RHEA_ID":11372,"DIRECTION":"UN","MASTER_ID":11372,"ec":"6.3.1.1","compounds":"ATP + L-aspartate + NH4(+) = AMP + diphosphate + H(+) + L-asparagine"}
{"X":14749,"RHEA_ID":11373,"DIRECTION":"LR","MASTER_ID":11372,"ecocyc":"ASNSYNA-RXN","macie":"M0075","metacyc":"ASNSYNA-RXN","compounds":"ATP + L-aspartate + NH4(+) => AMP + diphosphate + H(+) + L-asparagine"}
{"X":14750,"RHEA_ID":11374,"compounds":"AMP + diphosphate + H(+) + L-asparagine => ATP + L-aspartate + NH4(+)"}
{"X":14751,"RHEA_ID":21215,"compounds":"H2O + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein] <=> 4-hydroxy-2-oxobutanal + L-lysyl-[protein] + phosphate"}
{"X":14752,"RHEA_ID":11376,"DIRECTION":"UN","MASTER_ID":11376,"ec":"1.3.1.36","compounds":"(19S)-geissoschizine + NADP(+) = 4,21-dehydrogeissoschizine + NADPH"}
{"X":14753,"RHEA_ID":11377,"compounds":"(19S)-geissoschizine + NADP(+) => 4,21-dehydrogeissoschizine + NADPH"}
{"X":14754,"RHEA_ID":11378,"compounds":"4,21-dehydrogeissoschizine + NADPH => (19S)-geissoschizine + NADP(+)"}
{"X":14755,"RHEA_ID":11384,"DIRECTION":"UN","MASTER_ID":11384,"ec":"1.1.1.99","metacyc":"1.1.1.99-RXN","compounds":"(S)-2-hydroxydecanoate + NAD(+) = 2-oxodecanoate + H(+) + NADH"}
{"X":14756,"RHEA_ID":11385,"compounds":"(S)-2-hydroxydecanoate + NAD(+) => 2-oxodecanoate + H(+) + NADH"}
{"X":14757,"RHEA_ID":11386,"compounds":"2-oxodecanoate + H(+) + NADH => (S)-2-hydroxydecanoate + NAD(+)"}
{"X":14758,"RHEA_ID":31778,"compounds":"all-trans-retinyl hexadecanoate + H2O <=> 11-cis-retinol + H(+) + hexadecanoate"}
{"X":14759,"RHEA_ID":11388,"DIRECTION":"UN","MASTER_ID":11388,"ec":"1.1.1.146","compounds":"an 11beta-hydroxysteroid + NADP(+) = an 11-oxosteroid + H(+) + NADPH"}
{"X":14760,"RHEA_ID":11389,"compounds":"an 11beta-hydroxysteroid + NADP(+) => an 11-oxosteroid + H(+) + NADPH"}
{"X":14761,"RHEA_ID":11390,"compounds":"an 11-oxosteroid + H(+) + NADPH => an 11beta-hydroxysteroid + NADP(+)"}
{"X":14762,"RHEA_ID":11392,"DIRECTION":"UN","MASTER_ID":11392,"ec":"3.1.3.56","compounds":"1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate"}
{"X":14763,"RHEA_ID":11393,"DIRECTION":"LR","MASTER_ID":11392,"metacyc":"RXN-8730","reactome":"R-HSA-1855218.2","compounds":"1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O => 1D-myo-inositol 1,3,4-trisphosphate + phosphate"}
{"X":14764,"RHEA_ID":11393,"DIRECTION":"LR","MASTER_ID":11392,"metacyc":"RXN-8730","reactome":"R-HSA-1855213.2","compounds":"1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O => 1D-myo-inositol 1,3,4-trisphosphate + phosphate"}
{"X":14765,"RHEA_ID":11394,"compounds":"1D-myo-inositol 1,3,4-trisphosphate + phosphate => 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O"}
{"X":14766,"RHEA_ID":21232,"DIRECTION":"UN","MASTER_ID":21232,"ec":"4.3.1.3","compounds":"L-histidine = NH4(+) + trans-urocanate"}
{"X":14767,"RHEA_ID":11396,"DIRECTION":"UN","MASTER_ID":11396,"ec":"2.7.4.19","metacyc":"2.7.4.19-RXN","compounds":"5-methyldeoxycytidine 5'-phosphate + ATP = 5-methyldeoxycytidine diphosphate + ADP"}
{"X":14768,"RHEA_ID":11397,"compounds":"5-methyldeoxycytidine 5'-phosphate + ATP => 5-methyldeoxycytidine diphosphate + ADP"}
{"X":14769,"RHEA_ID":11398,"compounds":"5-methyldeoxycytidine diphosphate + ADP => 5-methyldeoxycytidine 5'-phosphate + ATP"}
{"X":14770,"RHEA_ID":21236,"DIRECTION":"UN","MASTER_ID":21236,"ec":"1.14.13.35","compounds":"anthranilate + 2 H(+) + NADPH + O2 = 2,3-dihydroxybenzoate + NADP(+) + NH4(+)"}
{"X":14771,"RHEA_ID":11400,"DIRECTION":"UN","MASTER_ID":11400,"ec":"2.4.1.353","compounds":"GDP-6-deoxy-alpha-D-altrose + sordaricin = 4'-O-demethylsordarin + GDP + H(+)"}
{"X":14772,"RHEA_ID":11401,"DIRECTION":"LR","MASTER_ID":11400,"metacyc":"RXN-18996","compounds":"GDP-6-deoxy-alpha-D-altrose + sordaricin => 4'-O-demethylsordarin + GDP + H(+)"}
{"X":14773,"RHEA_ID":11402,"compounds":"4'-O-demethylsordarin + GDP + H(+) => GDP-6-deoxy-alpha-D-altrose + sordaricin"}
{"X":14774,"RHEA_ID":21240,"DIRECTION":"UN","MASTER_ID":21240,"ec":"2.5.1.60","compounds":"geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein]"}
{"X":14775,"RHEA_ID":11404,"DIRECTION":"UN","MASTER_ID":11404,"ec":"5.1.3.6","compounds":"UDP-alpha-D-glucuronate = UDP-alpha-D-galacturonate"}
{"X":14776,"RHEA_ID":11405,"compounds":"UDP-alpha-D-glucuronate => UDP-alpha-D-galacturonate"}
{"X":14777,"RHEA_ID":11406,"compounds":"UDP-alpha-D-galacturonate => UDP-alpha-D-glucuronate"}
{"X":14778,"RHEA_ID":21243,"DIRECTION":"BI","MASTER_ID":21240,"metacyc":"RXN-3701","compounds":"geranylgeranyl diphosphate + L-cysteinyl-[protein] <=> diphosphate + S-geranylgeranyl-L-cysteinyl-[protein]"}
{"X":14779,"RHEA_ID":11408,"DIRECTION":"UN","MASTER_ID":11408,"ec":"3.5.99.1","metacyc":"RIBOFLAVINASE-RXN","compounds":"H(+) + H2O + riboflavin = lumichrome + ribitol"}
{"X":14780,"RHEA_ID":11409,"compounds":"H(+) + H2O + riboflavin => lumichrome + ribitol"}
{"X":14781,"RHEA_ID":11410,"compounds":"lumichrome + ribitol => H(+) + H2O + riboflavin"}
{"X":14782,"RHEA_ID":31803,"DIRECTION":"UN","MASTER_ID":31803,"ec":"3.6.1.57","compounds":"H2O + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose = 2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H(+) + UDP"}
{"X":14783,"RHEA_ID":11412,"DIRECTION":"UN","MASTER_ID":11412,"ec":"2.7.6.3","compounds":"6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)"}
{"X":14784,"RHEA_ID":11413,"DIRECTION":"LR","MASTER_ID":11412,"ecocyc":"H2PTERIDINEPYROPHOSPHOKIN-RXN","metacyc":"H2PTERIDINEPYROPHOSPHOKIN-RXN","compounds":"6-hydroxymethyl-7,8-dihydropterin + ATP => (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)"}
{"X":14785,"RHEA_ID":11414,"compounds":"(7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+) => 6-hydroxymethyl-7,8-dihydropterin + ATP"}
{"X":14786,"RHEA_ID":21250,"compounds":"diphosphate + RNA(n+1) => a ribonucleoside 5'-triphosphate + RNA(n)"}
{"X":14787,"RHEA_ID":11416,"DIRECTION":"UN","MASTER_ID":11416,"ec":"2.3.1.90","compounds":"2 1-O-galloyl-beta-D-glucose = 1,6-bis-O-galloyl-beta-D-glucose + D-glucose"}
{"X":14788,"RHEA_ID":11417,"DIRECTION":"LR","MASTER_ID":11416,"metacyc":"2.3.1.90-RXN","compounds":"2 1-O-galloyl-beta-D-glucose => 1,6-bis-O-galloyl-beta-D-glucose + D-glucose"}
{"X":14789,"RHEA_ID":11418,"compounds":"1,6-bis-O-galloyl-beta-D-glucose + D-glucose => 2 1-O-galloyl-beta-D-glucose"}
{"X":14790,"RHEA_ID":21253,"compounds":"(S)-2-hydroxyglutarate + A => 2-oxoglutarate + AH2"}
{"X":14791,"RHEA_ID":11420,"DIRECTION":"UN","MASTER_ID":11420,"ec":"1.14.13.101","compounds":"NADPH + O2 + senecionine = H2O + NADP(+) + senecionine N-oxide"}
{"X":14792,"RHEA_ID":11421,"DIRECTION":"LR","MASTER_ID":11420,"metacyc":"1.14.13.101-RXN","compounds":"NADPH + O2 + senecionine => H2O + NADP(+) + senecionine N-oxide"}
{"X":14793,"RHEA_ID":11422,"compounds":"H2O + NADP(+) + senecionine N-oxide => NADPH + O2 + senecionine"}
{"X":14794,"RHEA_ID":21257,"compounds":"3-phosphoshikimate + phosphoenolpyruvate => 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate"}
{"X":14795,"RHEA_ID":11424,"DIRECTION":"UN","MASTER_ID":11424,"ec":"2.7.11.7","compounds":"[myosin heavy-chain]-L-threonine + ATP = [myosin heavy-chain]-O-phospho-L-threonine + ADP + H(+)"}
{"X":14796,"RHEA_ID":11425,"compounds":"[myosin heavy-chain]-L-threonine + ATP => [myosin heavy-chain]-O-phospho-L-threonine + ADP + H(+)"}
{"X":14797,"RHEA_ID":11426,"compounds":"[myosin heavy-chain]-O-phospho-L-threonine + ADP + H(+) => [myosin heavy-chain]-L-threonine + ATP"}
{"X":14798,"RHEA_ID":21261,"compounds":"[thioredoxin]-disulfide + H2O + L-methionine => [thioredoxin]-dithiol + L-methionine (R)-S-oxide"}
{"X":14799,"RHEA_ID":11428,"DIRECTION":"UN","MASTER_ID":11428,"ec":"1.1.3.4","compounds":"beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2"}
{"X":14800,"RHEA_ID":11428,"DIRECTION":"UN","MASTER_ID":11428,"ec":"1.1.3.5","compounds":"beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2"}
{"X":14801,"RHEA_ID":11429,"DIRECTION":"LR","MASTER_ID":11428,"metacyc":"GLUCOSE-OXIDASE-RXN","compounds":"beta-D-glucose + O2 => D-glucono-1,5-lactone + H2O2"}
{"X":14802,"RHEA_ID":11430,"compounds":"D-glucono-1,5-lactone + H2O2 => beta-D-glucose + O2"}
{"X":14803,"RHEA_ID":21266,"compounds":"AH2 + glyoxylate => A + glycolate"}
{"X":14804,"RHEA_ID":11432,"DIRECTION":"UN","MASTER_ID":11432,"ec":"2.1.1.153","compounds":"S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside = 7-O-methylvitexin 2''-O-beta-L-rhamnoside + H(+) + S-adenosyl-L-homocysteine"}
{"X":14805,"RHEA_ID":11433,"DIRECTION":"LR","MASTER_ID":11432,"metacyc":"RXN-4981","compounds":"S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside => 7-O-methylvitexin 2''-O-beta-L-rhamnoside + H(+) + S-adenosyl-L-homocysteine"}
{"X":14806,"RHEA_ID":11434,"compounds":"7-O-methylvitexin 2''-O-beta-L-rhamnoside + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside"}
{"X":14807,"RHEA_ID":21270,"compounds":"berberine + H(+) + 2 NADPH => (R)-canadine + 2 NADP(+)"}
{"X":14808,"RHEA_ID":11436,"DIRECTION":"UN","MASTER_ID":11436,"ec":"7.1.1.9","compounds":"4 [Fe(II)cytochrome c] + 4 H(+) + O2 = 4 [Fe(III)cytochrome c] + 2 H2O"}
{"X":14809,"RHEA_ID":11437,"DIRECTION":"LR","MASTER_ID":11436,"metacyc":"CYTOCHROME-C-OXIDASE-RXN","compounds":"4 [Fe(II)cytochrome c] + 4 H(+) + O2 => 4 [Fe(III)cytochrome c] + 2 H2O"}
{"X":14810,"RHEA_ID":11438,"compounds":"4 [Fe(III)cytochrome c] + 2 H2O => 4 [Fe(II)cytochrome c] + 4 H(+) + O2"}
{"X":14811,"RHEA_ID":11440,"DIRECTION":"UN","MASTER_ID":11440,"ec":"1.14.13.50","compounds":"2,3,5,6-tetrachlorophenol + NADPH + O2 = 2,3,5,6-tetrachlorohydroquinone + H2O + NADP(+)"}
{"X":14812,"RHEA_ID":11441,"DIRECTION":"LR","MASTER_ID":11440,"metacyc":"RXN-8670","compounds":"2,3,5,6-tetrachlorophenol + NADPH + O2 => 2,3,5,6-tetrachlorohydroquinone + H2O + NADP(+)"}
{"X":14813,"RHEA_ID":11442,"compounds":"2,3,5,6-tetrachlorohydroquinone + H2O + NADP(+) => 2,3,5,6-tetrachlorophenol + NADPH + O2"}
{"X":14814,"RHEA_ID":21277,"compounds":"D-arabinitol + NADP(+) => D-xylulose + H(+) + NADPH"}
{"X":14815,"RHEA_ID":11444,"DIRECTION":"UN","MASTER_ID":11444,"ec":"3.1.6.9","compounds":"4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 4-sulfate + H2O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate"}
{"X":14816,"RHEA_ID":11445,"DIRECTION":"LR","MASTER_ID":11444,"metacyc":"CHONDRO-4-SULFATASE-RXN","compounds":"4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 4-sulfate + H2O => 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate"}
{"X":14817,"RHEA_ID":11446,"compounds":"4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate => 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 4-sulfate + H2O"}
{"X":14818,"RHEA_ID":21281,"DIRECTION":"LR","MASTER_ID":21280,"metacyc":"THIAMIN-OXIDASE-RXN","compounds":"H2O + 2 O2 + thiamine => H(+) + 2 H2O2 + thiamine acetate"}
{"X":14819,"RHEA_ID":11448,"DIRECTION":"UN","MASTER_ID":11448,"ec":"1.1.1.150","metacyc":"1.1.1.150-RXN","compounds":"NAD(+) + pregnan-21-ol = H(+) + NADH + pregnan-21-al"}
{"X":14820,"RHEA_ID":11449,"compounds":"NAD(+) + pregnan-21-ol => H(+) + NADH + pregnan-21-al"}
{"X":14821,"RHEA_ID":11450,"compounds":"H(+) + NADH + pregnan-21-al => NAD(+) + pregnan-21-ol"}
{"X":14822,"RHEA_ID":21285,"DIRECTION":"LR","MASTER_ID":21284,"reactome":"R-HSA-5362564.1","compounds":"all-trans-retinol + NAD(+) => all-trans-retinal + H(+) + NADH"}
{"X":14823,"RHEA_ID":11452,"DIRECTION":"UN","MASTER_ID":11452,"ec":"1.14.14.85","compounds":"7-deoxyloganin + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + loganin + oxidized [NADPH--hemoprotein reductase]"}
{"X":14824,"RHEA_ID":11453,"DIRECTION":"LR","MASTER_ID":11452,"metacyc":"1.14.13.74-RXN","compounds":"7-deoxyloganin + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + loganin + oxidized [NADPH--hemoprotein reductase]"}
{"X":14825,"RHEA_ID":11454,"compounds":"H(+) + H2O + loganin + oxidized [NADPH--hemoprotein reductase] => 7-deoxyloganin + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":14826,"RHEA_ID":21288,"DIRECTION":"UN","MASTER_ID":21288,"ec":"2.7.1.142","metacyc":"2.7.1.142-RXN","compounds":"D-glucose + sn-glycerol 3-phosphate = D-glucose 6-phosphate + glycerol"}
{"X":14827,"RHEA_ID":11456,"DIRECTION":"UN","MASTER_ID":11456,"ec":"2.4.1.101","compounds":"N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP"}
{"X":14828,"RHEA_ID":11457,"DIRECTION":"LR","MASTER_ID":11456,"metacyc":"2.4.1.101-RXN","compounds":"N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP"}
{"X":14829,"RHEA_ID":11458,"compounds":"H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":14830,"RHEA_ID":11460,"DIRECTION":"UN","MASTER_ID":11460,"ec":"2.7.1.147","compounds":"ADP + D-glucose = AMP + D-glucose 6-phosphate + H(+)"}
{"X":14831,"RHEA_ID":11461,"DIRECTION":"LR","MASTER_ID":11460,"metacyc":"R301-RXN","compounds":"ADP + D-glucose => AMP + D-glucose 6-phosphate + H(+)"}
{"X":14832,"RHEA_ID":11462,"compounds":"AMP + D-glucose 6-phosphate + H(+) => ADP + D-glucose"}
{"X":14833,"RHEA_ID":21296,"DIRECTION":"UN","MASTER_ID":21296,"ec":"1.1.1.48","compounds":"D-galactose + NAD(+) = D-galactono-1,4-lactone + H(+) + NADH"}
{"X":14834,"RHEA_ID":11464,"DIRECTION":"UN","MASTER_ID":11464,"ec":"1.8.4.1","metacyc":"1.8.4.1-RXN","compounds":"2 glutathione + L,L-homocystine = glutathione disulfide + 2 L-homocysteine"}
{"X":14835,"RHEA_ID":11465,"compounds":"2 glutathione + L,L-homocystine => glutathione disulfide + 2 L-homocysteine"}
{"X":14836,"RHEA_ID":11466,"compounds":"glutathione disulfide + 2 L-homocysteine => 2 glutathione + L,L-homocystine"}
{"X":14837,"RHEA_ID":21300,"DIRECTION":"UN","MASTER_ID":21300,"ec":"3.1.6.8","compounds":"H2O + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + sulfate"}
{"X":14838,"RHEA_ID":11468,"DIRECTION":"UN","MASTER_ID":11468,"ec":"2.6.1.32","compounds":"(S)-3-methyl-2-oxopentanoate + L-valine = 3-methyl-2-oxobutanoate + L-isoleucine"}
{"X":14839,"RHEA_ID":11469,"compounds":"(S)-3-methyl-2-oxopentanoate + L-valine => 3-methyl-2-oxobutanoate + L-isoleucine"}
{"X":14840,"RHEA_ID":11470,"compounds":"3-methyl-2-oxobutanoate + L-isoleucine => (S)-3-methyl-2-oxopentanoate + L-valine"}
{"X":14841,"RHEA_ID":21304,"compounds":"ent-kaur-16-en-19-ol + O2 + reduced [NADPH--hemoprotein reductase] = ent-kaur-16-en-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":14842,"RHEA_ID":11472,"DIRECTION":"UN","MASTER_ID":11472,"ec":"1.5.3.2","compounds":"an N-methyl-L-amino acid + H2O + O2 = an L-alpha-amino acid + formaldehyde + H2O2"}
{"X":14843,"RHEA_ID":11473,"DIRECTION":"LR","MASTER_ID":11472,"metacyc":"N-METHYL-L-AMINO-ACID-OXIDASE-RXN","compounds":"an N-methyl-L-amino acid + H2O + O2 => an L-alpha-amino acid + formaldehyde + H2O2"}
{"X":14844,"RHEA_ID":11474,"compounds":"an L-alpha-amino acid + formaldehyde + H2O2 => an N-methyl-L-amino acid + H2O + O2"}
{"X":14845,"RHEA_ID":11476,"DIRECTION":"UN","MASTER_ID":11476,"ec":"3.1.3.21","compounds":"glycerol 1-phosphate + H2O = glycerol + phosphate"}
{"X":14846,"RHEA_ID":11477,"DIRECTION":"LR","MASTER_ID":11476,"ecocyc":"GLYCEROL-1-PHOSPHATASE-RXN","metacyc":"GLYCEROL-1-PHOSPHATASE-RXN","compounds":"glycerol 1-phosphate + H2O => glycerol + phosphate"}
{"X":14847,"RHEA_ID":11478,"compounds":"glycerol + phosphate => glycerol 1-phosphate + H2O"}
{"X":14848,"RHEA_ID":11480,"DIRECTION":"UN","MASTER_ID":11480,"ec":"1.14.13.23","compounds":"3-hydroxybenzoate + H(+) + NADPH + O2 = 3,4-dihydroxybenzoate + H2O + NADP(+)"}
{"X":14849,"RHEA_ID":11481,"DIRECTION":"LR","MASTER_ID":11480,"metacyc":"3-HYDROXYBENZOATE-4-MONOOXYGENASE-RXN","compounds":"3-hydroxybenzoate + H(+) + NADPH + O2 => 3,4-dihydroxybenzoate + H2O + NADP(+)"}
{"X":14850,"RHEA_ID":11482,"compounds":"3,4-dihydroxybenzoate + H2O + NADP(+) => 3-hydroxybenzoate + H(+) + NADPH + O2"}
{"X":14851,"RHEA_ID":21316,"DIRECTION":"UN","MASTER_ID":21316,"ec":"3.1.1.51","compounds":"H2O + phorbol 12,13-dibutanoate = butanoate + H(+) + phorbol 13-butanoate"}
{"X":14852,"RHEA_ID":11484,"DIRECTION":"UN","MASTER_ID":11484,"ec":"7.1.1.8","compounds":"2 [Fe(III)cytochrome c](out) + a quinol = 2 [Fe(II)cytochrome c](out) + a quinone + 2 H(+)(out)"}
{"X":14853,"RHEA_ID":11485,"DIRECTION":"LR","MASTER_ID":11484,"metacyc":"RXN-15816","compounds":"2 [Fe(III)cytochrome c](out) + a quinol => 2 [Fe(II)cytochrome c](out) + a quinone + 2 H(+)(out)"}
{"X":14854,"RHEA_ID":11486,"compounds":"2 [Fe(II)cytochrome c](out) + a quinone + 2 H(+)(out) => 2 [Fe(III)cytochrome c](out) + a quinol"}
{"X":14855,"RHEA_ID":11488,"DIRECTION":"UN","MASTER_ID":11488,"ec":"2.3.1.76","compounds":"all-trans-retinol + an acyl-CoA = an all-trans-retinyl ester + CoA"}
{"X":14856,"RHEA_ID":11489,"compounds":"all-trans-retinol + an acyl-CoA => an all-trans-retinyl ester + CoA"}
{"X":14857,"RHEA_ID":11490,"compounds":"an all-trans-retinyl ester + CoA => all-trans-retinol + an acyl-CoA"}
{"X":14858,"RHEA_ID":21324,"DIRECTION":"UN","MASTER_ID":21324,"ec":"1.15.1.2","compounds":"2 H(+) + reduced [rubredoxin] + superoxide = H2O2 + oxidized [rubredoxin]"}
{"X":14859,"RHEA_ID":11492,"DIRECTION":"UN","MASTER_ID":11492,"ec":"4.1.1.81","compounds":"H(+) + O-phospho-L-threonine = (R)-1-aminopropan-2-yl phosphate + CO2"}
{"X":14860,"RHEA_ID":11493,"DIRECTION":"LR","MASTER_ID":11492,"metacyc":"4.1.1.81-RXN","compounds":"H(+) + O-phospho-L-threonine => (R)-1-aminopropan-2-yl phosphate + CO2"}
{"X":14861,"RHEA_ID":11494,"compounds":"(R)-1-aminopropan-2-yl phosphate + CO2 => H(+) + O-phospho-L-threonine"}
{"X":14862,"RHEA_ID":21328,"compounds":"cholesterol + O2 = cholest-4-en-3-one + H2O2"}
{"X":14863,"RHEA_ID":11496,"DIRECTION":"UN","MASTER_ID":11496,"ec":"2.5.1.53","compounds":"O-acetyl-L-serine + uracil = 3-(uracil-1-yl)-L-alanine + acetate + H(+)"}
{"X":14864,"RHEA_ID":11497,"DIRECTION":"LR","MASTER_ID":11496,"metacyc":"RXN-7541","compounds":"O-acetyl-L-serine + uracil => 3-(uracil-1-yl)-L-alanine + acetate + H(+)"}
{"X":14865,"RHEA_ID":11498,"compounds":"3-(uracil-1-yl)-L-alanine + acetate + H(+) => O-acetyl-L-serine + uracil"}
{"X":14866,"RHEA_ID":21332,"DIRECTION":"UN","MASTER_ID":21332,"ec":"2.3.1.3","metacyc":"GLUCOSAMINE-N-ACETYLTRANSFERASE-RXN","compounds":"acetyl-CoA + D-glucosamine = CoA + H(+) + N-acetyl-D-glucosamine"}
{"X":14867,"RHEA_ID":11500,"DIRECTION":"UN","MASTER_ID":11500,"ec":"3.1.3.45","compounds":"3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + H2O = 3-deoxy-alpha-D-manno-oct-2-ulosonate + phosphate"}
{"X":14868,"RHEA_ID":11501,"DIRECTION":"LR","MASTER_ID":11500,"ecocyc":"KDO-8PPHOSPHAT-RXN","metacyc":"KDO-8PPHOSPHAT-RXN","compounds":"3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + H2O => 3-deoxy-alpha-D-manno-oct-2-ulosonate + phosphate"}
{"X":14869,"RHEA_ID":11502,"compounds":"3-deoxy-alpha-D-manno-oct-2-ulosonate + phosphate => 3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + H2O"}
{"X":14870,"RHEA_ID":21336,"DIRECTION":"UN","MASTER_ID":21336,"ec":"1.1.1.107","compounds":"NAD(+) + pyridoxal = 4-pyridoxolactone + H(+) + NADH"}
{"X":14871,"RHEA_ID":11504,"DIRECTION":"UN","MASTER_ID":11504,"ec":"2.1.1.109","compounds":"6-demethylsterigmatocystin + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + sterigmatocystin"}
{"X":14872,"RHEA_ID":11505,"DIRECTION":"LR","MASTER_ID":11504,"metacyc":"2.1.1.109-RXN","compounds":"6-demethylsterigmatocystin + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + sterigmatocystin"}
{"X":14873,"RHEA_ID":11506,"compounds":"H(+) + S-adenosyl-L-homocysteine + sterigmatocystin => 6-demethylsterigmatocystin + S-adenosyl-L-methionine"}
{"X":14874,"RHEA_ID":21340,"DIRECTION":"UN","MASTER_ID":21340,"ec":"1.13.11.43","compounds":"1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O2 = 2 vanillin"}
{"X":14875,"RHEA_ID":11508,"DIRECTION":"UN","MASTER_ID":11508,"ec":"1.14.11.16","compounds":"2-oxoglutarate + L-aspartyl-[protein] + O2 = 3-hydroxy-L-aspartyl-[protein] + CO2 + succinate"}
{"X":14876,"RHEA_ID":11509,"DIRECTION":"LR","MASTER_ID":11508,"metacyc":"PEPTIDE-ASPARTATE-BETA-DIOXYGENASE-RXN","compounds":"2-oxoglutarate + L-aspartyl-[protein] + O2 => 3-hydroxy-L-aspartyl-[protein] + CO2 + succinate"}
{"X":14877,"RHEA_ID":11510,"compounds":"3-hydroxy-L-aspartyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-aspartyl-[protein] + O2"}
{"X":14878,"RHEA_ID":21344,"compounds":"5-hydroxybenzimidazolylcob(I)amide + H(+) + methanol = Co-methyl-Co-5-hydroxybenzimidazolylcob(III)amide + H2O"}
{"X":14879,"RHEA_ID":11512,"DIRECTION":"UN","MASTER_ID":11512,"ec":"2.4.1.172","compounds":"salicyl alcohol + UDP-alpha-D-glucose = H(+) + salicin + UDP"}
{"X":14880,"RHEA_ID":11513,"DIRECTION":"LR","MASTER_ID":11512,"metacyc":"SALICYL-ALCOHOL-GLUCOSYLTRANSFERASE-RXN","compounds":"salicyl alcohol + UDP-alpha-D-glucose => H(+) + salicin + UDP"}
{"X":14881,"RHEA_ID":11514,"compounds":"H(+) + salicin + UDP => salicyl alcohol + UDP-alpha-D-glucose"}
{"X":14882,"RHEA_ID":21348,"DIRECTION":"UN","MASTER_ID":21348,"ec":"2.3.1.235","metacyc":"RXN-15677","compounds":"8 H(+) + 10 malonyl-CoA = 10 CO2 + 10 CoA + 2 H2O + tetracenomycin F2"}
{"X":14883,"RHEA_ID":11516,"DIRECTION":"UN","MASTER_ID":11516,"ec":"3.1.2.3","compounds":"H2O + succinyl-CoA = CoA + H(+) + succinate"}
{"X":14884,"RHEA_ID":11517,"compounds":"H2O + succinyl-CoA => CoA + H(+) + succinate"}
{"X":14885,"RHEA_ID":11518,"compounds":"CoA + H(+) + succinate => H2O + succinyl-CoA"}
{"X":14886,"RHEA_ID":21352,"DIRECTION":"UN","MASTER_ID":21352,"ec":"1.13.11.25","compounds":"3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 = (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H(+)"}
{"X":14887,"RHEA_ID":11520,"DIRECTION":"UN","MASTER_ID":11520,"ec":"2.4.1.127","compounds":"(-)-menthol + UDP-alpha-D-glucose = (-)-menthyl beta-D-glucoside + H(+) + UDP"}
{"X":14888,"RHEA_ID":11521,"DIRECTION":"LR","MASTER_ID":11520,"metacyc":"2.4.1.127-RXN","compounds":"(-)-menthol + UDP-alpha-D-glucose => (-)-menthyl beta-D-glucoside + H(+) + UDP"}
{"X":14889,"RHEA_ID":11522,"compounds":"(-)-menthyl beta-D-glucoside + H(+) + UDP => (-)-menthol + UDP-alpha-D-glucose"}
{"X":14890,"RHEA_ID":21356,"DIRECTION":"UN","MASTER_ID":21356,"ec":"1.1.1.13","metacyc":"1.1.1.13-RXN","compounds":"L-arabinitol + NAD(+) = H(+) + L-ribulose + NADH"}
{"X":14891,"RHEA_ID":11524,"DIRECTION":"UN","MASTER_ID":11524,"ec":"1.3.1.3","compounds":"5beta-cholestan-3-one + NADP(+) = cholest-4-en-3-one + H(+) + NADPH"}
{"X":14892,"RHEA_ID":11525,"compounds":"5beta-cholestan-3-one + NADP(+) => cholest-4-en-3-one + H(+) + NADPH"}
{"X":14893,"RHEA_ID":11526,"compounds":"cholest-4-en-3-one + H(+) + NADPH => 5beta-cholestan-3-one + NADP(+)"}
{"X":14894,"RHEA_ID":21360,"DIRECTION":"UN","MASTER_ID":21360,"ec":"2.7.7.1","compounds":"ATP + beta-nicotinamide D-ribonucleotide + H(+) = diphosphate + NAD(+)"}
{"X":14895,"RHEA_ID":11528,"DIRECTION":"UN","MASTER_ID":11528,"ec":"2.5.1.17","compounds":"2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate"}
{"X":14896,"RHEA_ID":11529,"DIRECTION":"LR","MASTER_ID":11528,"metacyc":"RXN-19339","compounds":"2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] => 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate"}
{"X":14897,"RHEA_ID":11530,"compounds":"2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate => 2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein]"}
{"X":14898,"RHEA_ID":11532,"DIRECTION":"UN","MASTER_ID":11532,"ec":"1.4.3.19","compounds":"glycine + H2O + O2 = glyoxylate + H2O2 + NH4(+)"}
{"X":14899,"RHEA_ID":11533,"DIRECTION":"LR","MASTER_ID":11532,"metacyc":"1.4.3.19-RXN","reactome":"R-HSA-389821.1","compounds":"glycine + H2O + O2 => glyoxylate + H2O2 + NH4(+)"}
{"X":14900,"RHEA_ID":11534,"compounds":"glyoxylate + H2O2 + NH4(+) => glycine + H2O + O2"}
{"X":14901,"RHEA_ID":11536,"DIRECTION":"UN","MASTER_ID":11536,"ec":"1.1.3.17","compounds":"choline + H2O + 2 O2 = betaine + H(+) + 2 H2O2"}
{"X":14902,"RHEA_ID":11537,"DIRECTION":"LR","MASTER_ID":11536,"metacyc":"RXN-13178","compounds":"choline + H2O + 2 O2 => betaine + H(+) + 2 H2O2"}
{"X":14903,"RHEA_ID":11538,"compounds":"betaine + H(+) + 2 H2O2 => choline + H2O + 2 O2"}
{"X":14904,"RHEA_ID":21372,"DIRECTION":"UN","MASTER_ID":21372,"ec":"3.5.1.75","metacyc":"URETHANASE-RXN","compounds":"H(+) + H2O + urethane = CO2 + ethanol + NH4(+)"}
{"X":14905,"RHEA_ID":11540,"DIRECTION":"UN","MASTER_ID":11540,"ec":"1.1.1.233","compounds":"an N-acyl-D-mannosamine + NAD(+) = an N-acyl-D-mannosaminolactone + H(+) + NADH"}
{"X":14906,"RHEA_ID":11541,"compounds":"an N-acyl-D-mannosamine + NAD(+) => an N-acyl-D-mannosaminolactone + H(+) + NADH"}
{"X":14907,"RHEA_ID":11542,"compounds":"an N-acyl-D-mannosaminolactone + H(+) + NADH => an N-acyl-D-mannosamine + NAD(+)"}
{"X":14908,"RHEA_ID":11544,"DIRECTION":"UN","MASTER_ID":11544,"ec":"3.5.1.26","compounds":"H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine = H(+) + L-aspartate + N-acetyl-beta-D-glucosaminylamine"}
{"X":14909,"RHEA_ID":11545,"DIRECTION":"LR","MASTER_ID":11544,"macie":"M0266","metacyc":"3.5.1.26-RXN","compounds":"H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine => H(+) + L-aspartate + N-acetyl-beta-D-glucosaminylamine"}
{"X":14910,"RHEA_ID":11546,"compounds":"H(+) + L-aspartate + N-acetyl-beta-D-glucosaminylamine => H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine"}
{"X":14911,"RHEA_ID":21380,"DIRECTION":"UN","MASTER_ID":21380,"ec":"6.2.1.24","compounds":"3,7,11,15-tetramethylhexadecanoate + ATP + CoA = AMP + diphosphate + phytanoyl-CoA"}
{"X":14912,"RHEA_ID":11548,"DIRECTION":"UN","MASTER_ID":11548,"ec":"3.1.1.54","compounds":"5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene + H2O = 5-(4-hydroxy-but-1-ynyl)-2,2'-bithiophene + acetate + H(+)"}
{"X":14913,"RHEA_ID":11549,"DIRECTION":"LR","MASTER_ID":11548,"metacyc":"3.1.1.54-RXN","compounds":"5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene + H2O => 5-(4-hydroxy-but-1-ynyl)-2,2'-bithiophene + acetate + H(+)"}
{"X":14914,"RHEA_ID":11550,"compounds":"5-(4-hydroxy-but-1-ynyl)-2,2'-bithiophene + acetate + H(+) => 5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene + H2O"}
{"X":14915,"RHEA_ID":21384,"DIRECTION":"UN","MASTER_ID":21384,"ec":"4.3.1.25","compounds":"L-phenylalanine = NH4(+) + trans-cinnamate"}
{"X":14916,"RHEA_ID":11552,"DIRECTION":"UN","MASTER_ID":11552,"ec":"3.1.1.71","compounds":"a 1-O-alkyl-2-acetyl-sn-glycerol + H2O = 1-O-alkyl-sn-glycerol + acetate + H(+)"}
{"X":14917,"RHEA_ID":11553,"DIRECTION":"LR","MASTER_ID":11552,"metacyc":"3.1.1.71-RXN","compounds":"a 1-O-alkyl-2-acetyl-sn-glycerol + H2O => 1-O-alkyl-sn-glycerol + acetate + H(+)"}
{"X":14918,"RHEA_ID":11554,"compounds":"1-O-alkyl-sn-glycerol + acetate + H(+) => a 1-O-alkyl-2-acetyl-sn-glycerol + H2O"}
{"X":14919,"RHEA_ID":11556,"DIRECTION":"UN","MASTER_ID":11556,"ec":"1.1.1.254","compounds":"(S)-carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH"}
{"X":14920,"RHEA_ID":11557,"compounds":"(S)-carnitine + NAD(+) => 3-dehydrocarnitine + H(+) + NADH"}
{"X":14921,"RHEA_ID":11558,"compounds":"3-dehydrocarnitine + H(+) + NADH => (S)-carnitine + NAD(+)"}
{"X":14922,"RHEA_ID":31968,"DIRECTION":"LR","MASTER_ID":31967,"metacyc":"RXN-12884","compounds":"ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase] => ent-11beta-hydroxycassa-12,15-diene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":14923,"RHEA_ID":11560,"DIRECTION":"UN","MASTER_ID":11560,"ec":"1.3.1.25","compounds":"(1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+) = catechol + CO2 + NADH"}
{"X":14924,"RHEA_ID":11561,"DIRECTION":"LR","MASTER_ID":11560,"metacyc":"1.3.1.25-RXN","compounds":"(1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+) => catechol + CO2 + NADH"}
{"X":14925,"RHEA_ID":11562,"compounds":"catechol + CO2 + NADH => (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+)"}
{"X":14926,"RHEA_ID":31972,"DIRECTION":"LR","MASTER_ID":31971,"metacyc":"RXN-8855","compounds":"10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + NADPH + O2 => 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + H2O + NADP(+)"}
{"X":14927,"RHEA_ID":11564,"DIRECTION":"UN","MASTER_ID":11564,"ec":"2.4.1.321","compounds":"4-O-beta-D-glucopyranosyl-D-gluconate + phosphate = alpha-D-glucose 1-phosphate + D-gluconate"}
{"X":14928,"RHEA_ID":11565,"compounds":"4-O-beta-D-glucopyranosyl-D-gluconate + phosphate => alpha-D-glucose 1-phosphate + D-gluconate"}
{"X":14929,"RHEA_ID":11566,"compounds":"alpha-D-glucose 1-phosphate + D-gluconate => 4-O-beta-D-glucopyranosyl-D-gluconate + phosphate"}
{"X":14930,"RHEA_ID":31976,"DIRECTION":"LR","MASTER_ID":31975,"metacyc":"RXN-12885","compounds":"H(+) + NADPH + O2 + taxusin => 7beta-hydroxytaxusin + H2O + NADP(+)"}
{"X":14931,"RHEA_ID":11568,"DIRECTION":"UN","MASTER_ID":11568,"ec":"2.1.1.54","metacyc":"DEOXYCYTIDYLATE-C-METHYLTRANSFERASE-RXN","compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP = 5-methyldeoxycytidine 5'-phosphate + 7,8-dihydrofolate"}
{"X":14932,"RHEA_ID":11569,"compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP => 5-methyldeoxycytidine 5'-phosphate + 7,8-dihydrofolate"}
{"X":14933,"RHEA_ID":11570,"compounds":"5-methyldeoxycytidine 5'-phosphate + 7,8-dihydrofolate => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP"}
{"X":14934,"RHEA_ID":31980,"DIRECTION":"LR","MASTER_ID":31979,"metacyc":"RXN-12900","reactome":"R-HSA-139970.2","compounds":"NADPH + O2 + trimethylamine => H2O + NADP(+) + trimethylamine N-oxide"}
{"X":14935,"RHEA_ID":11572,"compounds":"FAD + H(+) + H2O + lithocholate = chenodeoxycholate + FADH2"}
{"X":14936,"RHEA_ID":11573,"compounds":"FAD + H(+) + H2O + lithocholate => chenodeoxycholate + FADH2"}
{"X":14937,"RHEA_ID":11574,"compounds":"chenodeoxycholate + FADH2 => FAD + H(+) + H2O + lithocholate"}
{"X":14938,"RHEA_ID":11576,"DIRECTION":"UN","MASTER_ID":11576,"ec":"2.7.6.2","compounds":"ATP + thiamine = AMP + H(+) + thiamine diphosphate"}
{"X":14939,"RHEA_ID":11577,"DIRECTION":"LR","MASTER_ID":11576,"metacyc":"THIAMIN-PYROPHOSPHOKINASE-RXN","reactome":"R-HSA-196761.1","compounds":"ATP + thiamine => AMP + H(+) + thiamine diphosphate"}
{"X":14940,"RHEA_ID":11578,"compounds":"AMP + H(+) + thiamine diphosphate => ATP + thiamine"}
{"X":14941,"RHEA_ID":31988,"compounds":"(S)-2,3-epoxysqualene => baruol"}
{"X":14942,"RHEA_ID":11580,"DIRECTION":"UN","MASTER_ID":11580,"ec":"2.7.8.11","compounds":"a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)"}
{"X":14943,"RHEA_ID":11581,"DIRECTION":"LR","MASTER_ID":11580,"metacyc":"2.7.8.11-RXN","compounds":"a CDP-1,2-diacyl-sn-glycerol + myo-inositol => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)"}
{"X":14944,"RHEA_ID":11582,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+) => a CDP-1,2-diacyl-sn-glycerol + myo-inositol"}
{"X":14945,"RHEA_ID":31992,"DIRECTION":"LR","MASTER_ID":31991,"metacyc":"RXN-12838","compounds":"(2E,6E)-farnesyl diphosphate => diphosphate + sesquithujene"}
{"X":14946,"RHEA_ID":11584,"DIRECTION":"UN","MASTER_ID":11584,"ec":"5.1.1.12","compounds":"L-ornithine = D-ornithine"}
{"X":14947,"RHEA_ID":11585,"compounds":"L-ornithine => D-ornithine"}
{"X":14948,"RHEA_ID":11586,"compounds":"D-ornithine => L-ornithine"}
{"X":14949,"RHEA_ID":31996,"DIRECTION":"LR","MASTER_ID":31995,"metacyc":"RXN-12837","compounds":"(2E,6E)-farnesyl diphosphate => 7-epi-sesquithujene + diphosphate"}
{"X":14950,"RHEA_ID":11588,"DIRECTION":"UN","MASTER_ID":11588,"ec":"1.3.99.16","compounds":"A + H2O + isoquinoline = AH2 + isoquinolin-1(2H)-one"}
{"X":14951,"RHEA_ID":11589,"compounds":"A + H2O + isoquinoline => AH2 + isoquinolin-1(2H)-one"}
{"X":14952,"RHEA_ID":11590,"compounds":"AH2 + isoquinolin-1(2H)-one => A + H2O + isoquinoline"}
{"X":14953,"RHEA_ID":32000,"DIRECTION":"LR","MASTER_ID":31999,"metacyc":"RXN-12836","compounds":"(2E,6E)-farnesyl diphosphate => bicyclogermacrene + diphosphate"}
{"X":14954,"RHEA_ID":11592,"DIRECTION":"UN","MASTER_ID":11592,"ec":"3.1.2.31","compounds":"dihydromonacolin L-[lovastatin nonaketide synthase] + H2O = dihydromonacolin L carboxylate + H(+) + holo-[lovastatin nonaketide synthase]"}
{"X":14955,"RHEA_ID":11593,"DIRECTION":"LR","MASTER_ID":11592,"metacyc":"RXN-15690","compounds":"dihydromonacolin L-[lovastatin nonaketide synthase] + H2O => dihydromonacolin L carboxylate + H(+) + holo-[lovastatin nonaketide synthase]"}
{"X":14956,"RHEA_ID":11594,"compounds":"dihydromonacolin L carboxylate + H(+) + holo-[lovastatin nonaketide synthase] => dihydromonacolin L-[lovastatin nonaketide synthase] + H2O"}
{"X":14957,"RHEA_ID":11596,"DIRECTION":"UN","MASTER_ID":11596,"ec":"4.1.1.23","compounds":"H(+) + orotidine 5'-phosphate = CO2 + UMP"}
{"X":14958,"RHEA_ID":11597,"DIRECTION":"LR","MASTER_ID":11596,"ecocyc":"OROTPDECARB-RXN","macie":"M0050","metacyc":"OROTPDECARB-RXN","reactome":"R-HSA-73564.2","compounds":"H(+) + orotidine 5'-phosphate => CO2 + UMP"}
{"X":14959,"RHEA_ID":11598,"compounds":"CO2 + UMP => H(+) + orotidine 5'-phosphate"}
{"X":14960,"RHEA_ID":11600,"DIRECTION":"UN","MASTER_ID":11600,"ec":"2.7.4.14","compounds":"ATP + CMP = ADP + CDP"}
{"X":14961,"RHEA_ID":11600,"DIRECTION":"UN","MASTER_ID":11600,"ec":"2.7.4.25","compounds":"ATP + CMP = ADP + CDP"}
{"X":14962,"RHEA_ID":11601,"DIRECTION":"LR","MASTER_ID":11600,"ecocyc":"RXN-11832","metacyc":"RXN-11832","compounds":"ATP + CMP => ADP + CDP"}
{"X":14963,"RHEA_ID":11602,"compounds":"ADP + CDP => ATP + CMP"}
{"X":14964,"RHEA_ID":21434,"DIRECTION":"RL","MASTER_ID":21432,"reactome":"R-HSA-71783.3","compounds":"H(+) + NADH + oxaloacetate => (S)-malate + NAD(+)"}
{"X":14965,"RHEA_ID":11604,"DIRECTION":"UN","MASTER_ID":11604,"ec":"2.3.1.136","compounds":"[(2->8)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA = [(2->8)-O(7),N-diacetyl-alpha-D-neuraminosyl](n) + n CoA"}
{"X":14966,"RHEA_ID":11605,"compounds":"[(2->8)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA => [(2->8)-O(7),N-diacetyl-alpha-D-neuraminosyl](n) + n CoA"}
{"X":14967,"RHEA_ID":11606,"compounds":"[(2->8)-O(7),N-diacetyl-alpha-D-neuraminosyl](n) + n CoA => [(2->8)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA"}
{"X":14968,"RHEA_ID":21438,"compounds":"[translation elongation factor 2]-phosphate + ADP + H(+) => [translation elongation factor 2] + ATP"}
{"X":14969,"RHEA_ID":11608,"DIRECTION":"UN","MASTER_ID":11608,"ec":"2.3.1.136","compounds":"[(2->8)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA = [(2->8)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA"}
{"X":14970,"RHEA_ID":11609,"DIRECTION":"LR","MASTER_ID":11608,"metacyc":"RXN-15208","compounds":"[(2->8)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA => [(2->8)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA"}
{"X":14971,"RHEA_ID":11610,"compounds":"[(2->8)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA => [(2->8)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA"}
{"X":14972,"RHEA_ID":21442,"compounds":"a long-chain alkane + formate + H2O + 2 NADP(+) => a long-chain fatty aldehyde + H(+) + 2 NADPH + O2"}
{"X":14973,"RHEA_ID":11612,"DIRECTION":"UN","MASTER_ID":11612,"ec":"1.4.1.3","compounds":"H2O + L-glutamate + NADP(+) = 2-oxoglutarate + H(+) + NADPH + NH4(+)"}
{"X":14974,"RHEA_ID":11612,"DIRECTION":"UN","MASTER_ID":11612,"ec":"1.4.1.4","compounds":"H2O + L-glutamate + NADP(+) = 2-oxoglutarate + H(+) + NADPH + NH4(+)"}
{"X":14975,"RHEA_ID":11613,"DIRECTION":"LR","MASTER_ID":11612,"metacyc":"GLUTAMATESYN-RXN","reactome":"R-HSA-70600.4","compounds":"H2O + L-glutamate + NADP(+) => 2-oxoglutarate + H(+) + NADPH + NH4(+)"}
{"X":14976,"RHEA_ID":11614,"DIRECTION":"RL","MASTER_ID":11612,"reactome":"R-HSA-70589.4","compounds":"2-oxoglutarate + H(+) + NADPH + NH4(+) => H2O + L-glutamate + NADP(+)"}
{"X":14977,"RHEA_ID":41993,"compounds":"17beta-hydroxy-5alpha-androstan-3-one + NAD(+) => 5alpha-androstan-3,17-dione + H(+) + NADH"}
{"X":14978,"RHEA_ID":21448,"DIRECTION":"UN","MASTER_ID":21448,"ec":"1.18.6.1","compounds":"16 ATP + 16 H2O + N2 + 8 reduced [2Fe-2S]-[ferredoxin] = 16 ADP + 6 H(+) + H2 + 2 NH4(+) + 8 oxidized [2Fe-2S]-[ferredoxin] + 16 phosphate"}
{"X":14979,"RHEA_ID":11620,"DIRECTION":"UN","MASTER_ID":11620,"ec":"4.5.1.4","compounds":"H2O + L-2-amino-4-chloropent-4-enoate = 2-oxopent-4-enoate + chloride + H(+) + NH4(+)"}
{"X":14980,"RHEA_ID":11621,"DIRECTION":"LR","MASTER_ID":11620,"metacyc":"4.5.1.4-RXN","compounds":"H2O + L-2-amino-4-chloropent-4-enoate => 2-oxopent-4-enoate + chloride + H(+) + NH4(+)"}
{"X":14981,"RHEA_ID":11622,"compounds":"2-oxopent-4-enoate + chloride + H(+) + NH4(+) => H2O + L-2-amino-4-chloropent-4-enoate"}
{"X":14982,"RHEA_ID":21452,"DIRECTION":"UN","MASTER_ID":21452,"ec":"1.14.17.3","compounds":"a [peptide]-C-terminal glycine + 2 L-ascorbate + O2 = a [peptide]-C-terminal (2S)-2-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical"}
{"X":14983,"RHEA_ID":11624,"DIRECTION":"UN","MASTER_ID":11624,"ec":"2.6.3.1","metacyc":"OXIMINOTRANSFERASE-RXN","compounds":"2-(hydroxyimino)propanoate + acetone = acetone oxime + pyruvate"}
{"X":14984,"RHEA_ID":11625,"compounds":"2-(hydroxyimino)propanoate + acetone => acetone oxime + pyruvate"}
{"X":14985,"RHEA_ID":11626,"compounds":"acetone oxime + pyruvate => 2-(hydroxyimino)propanoate + acetone"}
{"X":14986,"RHEA_ID":11628,"DIRECTION":"UN","MASTER_ID":11628,"ec":"4.1.1.1","compounds":"a 2-oxocarboxylate + H(+) = an aldehyde + CO2"}
{"X":14987,"RHEA_ID":11629,"compounds":"a 2-oxocarboxylate + H(+) => an aldehyde + CO2"}
{"X":14988,"RHEA_ID":11630,"compounds":"an aldehyde + CO2 => a 2-oxocarboxylate + H(+)"}
{"X":14989,"RHEA_ID":11632,"DIRECTION":"UN","MASTER_ID":11632,"ec":"4.4.1.16","compounds":"AH2 + L-selenocysteine = A + H(+) + hydrogenselenide + L-alanine"}
{"X":14990,"RHEA_ID":11633,"compounds":"AH2 + L-selenocysteine => A + H(+) + hydrogenselenide + L-alanine"}
{"X":14991,"RHEA_ID":11634,"compounds":"A + H(+) + hydrogenselenide + L-alanine => AH2 + L-selenocysteine"}
{"X":14992,"RHEA_ID":11636,"DIRECTION":"UN","MASTER_ID":11636,"ec":"1.1.1.197","compounds":"NADP(+) + prostaglandin E1 = 15-oxo-prostaglandin E1 + H(+) + NADPH"}
{"X":14993,"RHEA_ID":11637,"compounds":"NADP(+) + prostaglandin E1 => 15-oxo-prostaglandin E1 + H(+) + NADPH"}
{"X":14994,"RHEA_ID":11638,"compounds":"15-oxo-prostaglandin E1 + H(+) + NADPH => NADP(+) + prostaglandin E1"}
{"X":14995,"RHEA_ID":21468,"DIRECTION":"UN","MASTER_ID":21468,"ec":"2.4.1.316","compounds":"dTDP-alpha-D-mycaminose + tylactone = 5-O-beta-D-mycaminosyltylactone + dTDP + H(+)"}
{"X":14996,"RHEA_ID":11640,"DIRECTION":"UN","MASTER_ID":11640,"ec":"1.3.1.77","compounds":"a (2R,3R)-flavan-3-ol + 2 NAD(+) = an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADH"}
{"X":14997,"RHEA_ID":11641,"compounds":"a (2R,3R)-flavan-3-ol + 2 NAD(+) => an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADH"}
{"X":14998,"RHEA_ID":11642,"DIRECTION":"RL","MASTER_ID":11640,"metacyc":"RXN-10693","compounds":"an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADH => a (2R,3R)-flavan-3-ol + 2 NAD(+)"}
{"X":14999,"RHEA_ID":21472,"DIRECTION":"UN","MASTER_ID":21472,"ec":"6.2.1.18","compounds":"ATP + citrate + CoA = (3S)-citryl-CoA + ADP + phosphate"}
{"X":15000,"RHEA_ID":11644,"DIRECTION":"UN","MASTER_ID":11644,"ec":"1.3.1.77","compounds":"a (2R,3R)-flavan-3-ol + 2 NADP(+) = an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH"}
{"X":15001,"RHEA_ID":11645,"compounds":"a (2R,3R)-flavan-3-ol + 2 NADP(+) => an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH"}
{"X":15002,"RHEA_ID":11646,"DIRECTION":"RL","MASTER_ID":11644,"metacyc":"RXN-10693","compounds":"an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH => a (2R,3R)-flavan-3-ol + 2 NADP(+)"}
{"X":15003,"RHEA_ID":21476,"DIRECTION":"UN","MASTER_ID":21476,"ec":"2.4.1.34","compounds":"[(1->3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->3)-beta-D-glucosyl](n+1) + H(+) + UDP"}
{"X":15004,"RHEA_ID":11648,"DIRECTION":"UN","MASTER_ID":11648,"ec":"1.14.13.46","compounds":"(-)-menthol + H(+) + NADPH + O2 = 1,4-menthane-3,8-diol + H2O + NADP(+)"}
{"X":15005,"RHEA_ID":11649,"DIRECTION":"LR","MASTER_ID":11648,"metacyc":"--MENTHOL-MONOOXYGENASE-RXN","compounds":"(-)-menthol + H(+) + NADPH + O2 => 1,4-menthane-3,8-diol + H2O + NADP(+)"}
{"X":15006,"RHEA_ID":11650,"compounds":"1,4-menthane-3,8-diol + H2O + NADP(+) => (-)-menthol + H(+) + NADPH + O2"}
{"X":15007,"RHEA_ID":21480,"DIRECTION":"UN","MASTER_ID":21480,"ec":"1.3.99.8","compounds":"2-furoyl-CoA + A + H2O = 5-hydroxy-2-furoyl-CoA + AH2 + H(+)"}
{"X":15008,"RHEA_ID":11652,"DIRECTION":"UN","MASTER_ID":11652,"ec":"2.7.8.6","compounds":"di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-galactose = alpha-D-galactosyl di-trans,octa-cis-undecaprenyl diphosphate + UMP"}
{"X":15009,"RHEA_ID":11653,"compounds":"di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-galactose => alpha-D-galactosyl di-trans,octa-cis-undecaprenyl diphosphate + UMP"}
{"X":15010,"RHEA_ID":11654,"compounds":"alpha-D-galactosyl di-trans,octa-cis-undecaprenyl diphosphate + UMP => di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-galactose"}
{"X":15011,"RHEA_ID":21488,"DIRECTION":"UN","MASTER_ID":21488,"ec":"3.2.1.161","compounds":"dalnigrein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O = beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalnigrein + H(+)"}
{"X":15012,"RHEA_ID":11656,"DIRECTION":"UN","MASTER_ID":11656,"ec":"6.2.1.53","compounds":"ATP + holo-[peptidyl-carrier protein] + L-proline = AMP + diphosphate + L-prolyl-[peptidyl-carrier protein]"}
{"X":15013,"RHEA_ID":11657,"DIRECTION":"LR","MASTER_ID":11656,"metacyc":"RXN-19068","compounds":"ATP + holo-[peptidyl-carrier protein] + L-proline => AMP + diphosphate + L-prolyl-[peptidyl-carrier protein]"}
{"X":15014,"RHEA_ID":11658,"compounds":"AMP + diphosphate + L-prolyl-[peptidyl-carrier protein] => ATP + holo-[peptidyl-carrier protein] + L-proline"}
{"X":15015,"RHEA_ID":21492,"DIRECTION":"UN","MASTER_ID":21492,"ec":"4.1.1.46","compounds":"2,3-dihydroxybenzoate + H(+) = catechol + CO2"}
{"X":15016,"RHEA_ID":11660,"DIRECTION":"UN","MASTER_ID":11660,"ec":"3.5.1.89","compounds":"a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O = a 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + acetate"}
{"X":15017,"RHEA_ID":11661,"compounds":"a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O => a 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + acetate"}
{"X":15018,"RHEA_ID":11662,"compounds":"a 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + acetate => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O"}
{"X":15019,"RHEA_ID":11664,"DIRECTION":"UN","MASTER_ID":11664,"ec":"2.4.99.5","compounds":"a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + CMP-N-acetyl-beta-neuraminate = 1,2-diacyl-3-[3-(N-acetyl-alpha-D-neuraminyl)-beta-D-galactosyl]-sn-glycerol + CMP + H(+)"}
{"X":15020,"RHEA_ID":11665,"DIRECTION":"LR","MASTER_ID":11664,"metacyc":"2.4.99.5-RXN","compounds":"a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + CMP-N-acetyl-beta-neuraminate => 1,2-diacyl-3-[3-(N-acetyl-alpha-D-neuraminyl)-beta-D-galactosyl]-sn-glycerol + CMP + H(+)"}
{"X":15021,"RHEA_ID":11666,"compounds":"1,2-diacyl-3-[3-(N-acetyl-alpha-D-neuraminyl)-beta-D-galactosyl]-sn-glycerol + CMP + H(+) => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + CMP-N-acetyl-beta-neuraminate"}
{"X":15022,"RHEA_ID":21500,"DIRECTION":"UN","MASTER_ID":21500,"ec":"4.2.1.76","compounds":"UDP-alpha-D-glucose = H2O + UDP-4-dehydro-6-deoxy-alpha-D-glucose"}
{"X":15023,"RHEA_ID":11668,"DIRECTION":"UN","MASTER_ID":11668,"ec":"2.7.9.4","compounds":"[(1->4)-alpha-D-glucosyl](n) + n ATP + n H2O = [(1->4)-6-phospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate"}
{"X":15024,"RHEA_ID":11669,"compounds":"[(1->4)-alpha-D-glucosyl](n) + n ATP + n H2O => [(1->4)-6-phospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate"}
{"X":15025,"RHEA_ID":11670,"compounds":"[(1->4)-6-phospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate => [(1->4)-alpha-D-glucosyl](n) + n ATP + n H2O"}
{"X":15026,"RHEA_ID":11671,"DIRECTION":"BI","MASTER_ID":11668,"metacyc":"2.7.9.4-RXN","compounds":"[(1->4)-alpha-D-glucosyl](n) + n ATP + n H2O <=> [(1->4)-6-phospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate"}
{"X":15027,"RHEA_ID":11672,"DIRECTION":"UN","MASTER_ID":11672,"ec":"2.6.1.85","compounds":"chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate"}
{"X":15028,"RHEA_ID":11673,"DIRECTION":"LR","MASTER_ID":11672,"macie":"M0283","compounds":"chorismate + L-glutamine => 4-amino-4-deoxychorismate + L-glutamate"}
{"X":15029,"RHEA_ID":11674,"compounds":"4-amino-4-deoxychorismate + L-glutamate => chorismate + L-glutamine"}
{"X":15030,"RHEA_ID":21508,"compounds":"all-trans-retinyl hexadecanoate + H2O = H(+) + hexadecanoate + retinol"}
{"X":15031,"RHEA_ID":11676,"DIRECTION":"UN","MASTER_ID":11676,"ec":"1.1.1.115","metacyc":"RIBOSE-1-DEHYDROGENASE-NADP%252b-RXN","compounds":"D-ribose + H2O + NADP(+) = D-ribonate + 2 H(+) + NADPH"}
{"X":15032,"RHEA_ID":11677,"compounds":"D-ribose + H2O + NADP(+) => D-ribonate + 2 H(+) + NADPH"}
{"X":15033,"RHEA_ID":11678,"compounds":"D-ribonate + 2 H(+) + NADPH => D-ribose + H2O + NADP(+)"}
{"X":15034,"RHEA_ID":21512,"DIRECTION":"UN","MASTER_ID":21512,"ec":"5.5.1.25","compounds":"3,6-anhydro-L-galactonate = 2-dehydro-3-deoxy-L-galactonate"}
{"X":15035,"RHEA_ID":11680,"DIRECTION":"UN","MASTER_ID":11680,"ec":"6.3.5.2","compounds":"ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate"}
{"X":15036,"RHEA_ID":11681,"DIRECTION":"LR","MASTER_ID":11680,"ecocyc":"GMP-SYN-GLUT-RXN","macie":"M0234","metacyc":"GMP-SYN-GLUT-RXN","reactome":"R-HSA-73792.3","compounds":"ATP + H2O + L-glutamine + XMP => AMP + diphosphate + GMP + 2 H(+) + L-glutamate"}
{"X":15037,"RHEA_ID":11682,"compounds":"AMP + diphosphate + GMP + 2 H(+) + L-glutamate => ATP + H2O + L-glutamine + XMP"}
{"X":15038,"RHEA_ID":21516,"DIRECTION":"UN","MASTER_ID":21516,"ec":"5.3.3.11","metacyc":"ISOPIPERITENONE-DELTA-ISOMERASE-RXN","compounds":"isopiperitenone = piperitenone"}
{"X":15039,"RHEA_ID":11684,"DIRECTION":"UN","MASTER_ID":11684,"ec":"2.1.1.137","compounds":"methylarsonous acid + S-adenosyl-L-methionine = dimethylarsinate + 2 H(+) + S-adenosyl-L-homocysteine"}
{"X":15040,"RHEA_ID":11685,"DIRECTION":"LR","MASTER_ID":11684,"metacyc":"2.1.1.138-RXN","reactome":"R-HSA-5696213.1","compounds":"methylarsonous acid + S-adenosyl-L-methionine => dimethylarsinate + 2 H(+) + S-adenosyl-L-homocysteine"}
{"X":15041,"RHEA_ID":11685,"DIRECTION":"LR","MASTER_ID":11684,"metacyc":"2.1.1.138-RXN","reactome":"R-HSA-6800149.1","compounds":"methylarsonous acid + S-adenosyl-L-methionine => dimethylarsinate + 2 H(+) + S-adenosyl-L-homocysteine"}
{"X":15042,"RHEA_ID":11686,"compounds":"dimethylarsinate + 2 H(+) + S-adenosyl-L-homocysteine => methylarsonous acid + S-adenosyl-L-methionine"}
{"X":15043,"RHEA_ID":21521,"compounds":"2 [Fe(III)-cytochrome b1] + formate => 2 [Fe(II)-cytochrome b1] + CO2 + H(+)"}
{"X":15044,"RHEA_ID":11688,"DIRECTION":"UN","MASTER_ID":11688,"ec":"6.1.1.4","compounds":"ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)"}
{"X":15045,"RHEA_ID":11689,"DIRECTION":"LR","MASTER_ID":11688,"ecocyc":"LEUCINE--TRNA-LIGASE-RXN","metacyc":"LEUCINE--TRNA-LIGASE-RXN","compounds":"ATP + L-leucine + tRNA(Leu) => AMP + diphosphate + L-leucyl-tRNA(Leu)"}
{"X":15046,"RHEA_ID":11690,"compounds":"AMP + diphosphate + L-leucyl-tRNA(Leu) => ATP + L-leucine + tRNA(Leu)"}
{"X":15047,"RHEA_ID":21525,"DIRECTION":"LR","MASTER_ID":21524,"ecocyc":"2-ISOPROPYLMALATESYN-RXN","metacyc":"2-ISOPROPYLMALATESYN-RXN","compounds":"3-methyl-2-oxobutanoate + acetyl-CoA + H2O => (2S)-2-isopropylmalate + CoA + H(+)"}
{"X":15048,"RHEA_ID":11692,"DIRECTION":"UN","MASTER_ID":11692,"ec":"1.6.1.1","compounds":"NAD(+) + NADPH = NADH + NADP(+)"}
{"X":15049,"RHEA_ID":11692,"DIRECTION":"UN","MASTER_ID":11692,"ec":"1.6.1.2","compounds":"NAD(+) + NADPH = NADH + NADP(+)"}
{"X":15050,"RHEA_ID":11692,"DIRECTION":"UN","MASTER_ID":11692,"ec":"1.6.1.3","compounds":"NAD(+) + NADPH = NADH + NADP(+)"}
{"X":15051,"RHEA_ID":11693,"DIRECTION":"LR","MASTER_ID":11692,"ecocyc":"PYRNUTRANSHYDROGEN-RXN","metacyc":"PYRNUTRANSHYDROGEN-RXN","compounds":"NAD(+) + NADPH => NADH + NADP(+)"}
{"X":15052,"RHEA_ID":11694,"DIRECTION":"RL","MASTER_ID":11692,"macie":"M0116","compounds":"NADH + NADP(+) => NAD(+) + NADPH"}
{"X":15053,"RHEA_ID":11696,"DIRECTION":"UN","MASTER_ID":11696,"ec":"2.1.1.139","compounds":"3'-demethylstaurosporine + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + staurosporine"}
{"X":15054,"RHEA_ID":11697,"DIRECTION":"LR","MASTER_ID":11696,"metacyc":"2.1.1.139-RXN","compounds":"3'-demethylstaurosporine + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + staurosporine"}
{"X":15055,"RHEA_ID":11698,"compounds":"H(+) + S-adenosyl-L-homocysteine + staurosporine => 3'-demethylstaurosporine + S-adenosyl-L-methionine"}
{"X":15056,"RHEA_ID":32113,"compounds":"3-methoxy-4',5-dihydroxy-trans-stilbene + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + trans-resveratrol"}
{"X":15057,"RHEA_ID":11700,"DIRECTION":"UN","MASTER_ID":11700,"ec":"1.14.13.54","compounds":"H(+) + NADPH + O2 + progesterone = H2O + NADP(+) + testosterone acetate"}
{"X":15058,"RHEA_ID":11701,"DIRECTION":"LR","MASTER_ID":11700,"metacyc":"RXN-7817","compounds":"H(+) + NADPH + O2 + progesterone => H2O + NADP(+) + testosterone acetate"}
{"X":15059,"RHEA_ID":11702,"compounds":"H2O + NADP(+) + testosterone acetate => H(+) + NADPH + O2 + progesterone"}
{"X":15060,"RHEA_ID":32117,"compounds":"CO2 + succinate + TRIBOA beta-D-glucoside => 2-oxoglutarate + DIBOA beta-D-glucoside + O2"}
{"X":15061,"RHEA_ID":11704,"compounds":"2 H(+) + N-(carboxyaminomethyl)urea = CO2 + N-(aminomethyl)urea"}
{"X":15062,"RHEA_ID":11705,"DIRECTION":"LR","MASTER_ID":11704,"metacyc":"RXN-13200","compounds":"2 H(+) + N-(carboxyaminomethyl)urea => CO2 + N-(aminomethyl)urea"}
{"X":15063,"RHEA_ID":11706,"compounds":"CO2 + N-(aminomethyl)urea => 2 H(+) + N-(carboxyaminomethyl)urea"}
{"X":15064,"RHEA_ID":11708,"DIRECTION":"UN","MASTER_ID":11708,"ec":"1.1.1.205","compounds":"H2O + IMP + NAD(+) = H(+) + NADH + XMP"}
{"X":15065,"RHEA_ID":11709,"DIRECTION":"LR","MASTER_ID":11708,"reactome":"R-HSA-73794.4","compounds":"H2O + IMP + NAD(+) => H(+) + NADH + XMP"}
{"X":15066,"RHEA_ID":11710,"compounds":"H(+) + NADH + XMP => H2O + IMP + NAD(+)"}
{"X":15067,"RHEA_ID":32125,"compounds":"citrate(out) + H(+)(out) => citrate(in) + H(+)(in)"}
{"X":15068,"RHEA_ID":11712,"DIRECTION":"UN","MASTER_ID":11712,"ec":"1.2.7.7","compounds":"3-methyl-2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = 2-methylpropanoyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":15069,"RHEA_ID":11713,"compounds":"3-methyl-2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-methylpropanoyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":15070,"RHEA_ID":11714,"compounds":"2-methylpropanoyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => 3-methyl-2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":15071,"RHEA_ID":21551,"compounds":"H2O + N(6)-acetyl-L-lysyl-[alpha-tubulin] <=> acetate + L-lysyl-[alpha-tubulin]"}
{"X":15072,"RHEA_ID":11716,"DIRECTION":"UN","MASTER_ID":11716,"ec":"3.5.1.3","compounds":"a monoamide of a dicarboxylate + H2O = a dicarboxylate + NH4(+)"}
{"X":15073,"RHEA_ID":11717,"compounds":"a monoamide of a dicarboxylate + H2O => a dicarboxylate + NH4(+)"}
{"X":15074,"RHEA_ID":11718,"compounds":"a dicarboxylate + NH4(+) => a monoamide of a dicarboxylate + H2O"}
{"X":15075,"RHEA_ID":11720,"DIRECTION":"UN","MASTER_ID":11720,"ec":"3.5.2.14","compounds":"ATP + 2 H2O + N-methylhydantoin = ADP + 2 H(+) + N-carbamoylsarcosine + phosphate"}
{"X":15076,"RHEA_ID":11721,"DIRECTION":"LR","MASTER_ID":11720,"metacyc":"3.5.2.14-RXN","compounds":"ATP + 2 H2O + N-methylhydantoin => ADP + 2 H(+) + N-carbamoylsarcosine + phosphate"}
{"X":15077,"RHEA_ID":11722,"compounds":"ADP + 2 H(+) + N-carbamoylsarcosine + phosphate => ATP + 2 H2O + N-methylhydantoin"}
{"X":15078,"RHEA_ID":32137,"compounds":"CO2 + H(+) + propanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin] => 2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":15079,"RHEA_ID":11724,"DIRECTION":"UN","MASTER_ID":11724,"ec":"1.8.4.8","compounds":"[thioredoxin]-disulfide + adenosine 3',5'-bisphosphate + 2 H(+) + sulfite = 3'-phosphoadenylyl sulfate + [thioredoxin]-dithiol"}
{"X":15080,"RHEA_ID":11725,"compounds":"[thioredoxin]-disulfide + adenosine 3',5'-bisphosphate + 2 H(+) + sulfite => 3'-phosphoadenylyl sulfate + [thioredoxin]-dithiol"}
{"X":15081,"RHEA_ID":11726,"DIRECTION":"RL","MASTER_ID":11724,"ecocyc":"1.8.4.8-RXN","compounds":"3'-phosphoadenylyl sulfate + [thioredoxin]-dithiol => [thioredoxin]-disulfide + adenosine 3',5'-bisphosphate + 2 H(+) + sulfite"}
{"X":15082,"RHEA_ID":32141,"compounds":"AMP + diphosphate + malonyl-CoA => ATP + CoA + malonate"}
{"X":15083,"RHEA_ID":11728,"DIRECTION":"UN","MASTER_ID":11728,"ec":"1.1.1.163","compounds":"cyclopentanol + NAD(+) = cyclopentanone + H(+) + NADH"}
{"X":15084,"RHEA_ID":11729,"compounds":"cyclopentanol + NAD(+) => cyclopentanone + H(+) + NADH"}
{"X":15085,"RHEA_ID":11730,"compounds":"cyclopentanone + H(+) + NADH => cyclopentanol + NAD(+)"}
{"X":15086,"RHEA_ID":11732,"DIRECTION":"UN","MASTER_ID":11732,"ec":"1.14.14.142","compounds":"O2 + reduced [NADPH--hemoprotein reductase] + sophoraflavanone B = H(+) + H2O + leachianone G + oxidized [NADPH--hemoprotein reductase]"}
{"X":15087,"RHEA_ID":11733,"DIRECTION":"LR","MASTER_ID":11732,"metacyc":"1.14.13.103-RXN","compounds":"O2 + reduced [NADPH--hemoprotein reductase] + sophoraflavanone B => H(+) + H2O + leachianone G + oxidized [NADPH--hemoprotein reductase]"}
{"X":15088,"RHEA_ID":11734,"compounds":"H(+) + H2O + leachianone G + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + sophoraflavanone B"}
{"X":15089,"RHEA_ID":32144,"DIRECTION":"LR","MASTER_ID":32143,"reactome":"R-HSA-8959781.1","compounds":"L-arginine(in) => L-arginine(out)"}
{"X":15090,"RHEA_ID":11736,"DIRECTION":"UN","MASTER_ID":11736,"ec":"1.1.1.241","compounds":"2-exo-hydroxy-1,8-cineole + NAD(+) = 6-oxocineole + H(+) + NADH"}
{"X":15091,"RHEA_ID":11737,"DIRECTION":"LR","MASTER_ID":11736,"metacyc":"6-ENDO-HYDROXYCINEOLE-DEHYDROGENASE-RXN","compounds":"2-exo-hydroxy-1,8-cineole + NAD(+) => 6-oxocineole + H(+) + NADH"}
{"X":15092,"RHEA_ID":11738,"compounds":"6-oxocineole + H(+) + NADH => 2-exo-hydroxy-1,8-cineole + NAD(+)"}
{"X":15093,"RHEA_ID":32147,"compounds":"H2O + sepiapterin = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + H(+)"}
{"X":15094,"RHEA_ID":11740,"DIRECTION":"UN","MASTER_ID":11740,"ec":"1.8.1.7","compounds":"2 glutathione + NADP(+) = glutathione disulfide + H(+) + NADPH"}
{"X":15095,"RHEA_ID":11741,"compounds":"2 glutathione + NADP(+) => glutathione disulfide + H(+) + NADPH"}
{"X":15096,"RHEA_ID":11742,"DIRECTION":"RL","MASTER_ID":11740,"ecocyc":"GLUTATHIONE-REDUCT-NADPH-RXN","macie":"M0006","metacyc":"GLUTATHIONE-REDUCT-NADPH-RXN","reactome":"R-HSA-71682.3","compounds":"glutathione disulfide + H(+) + NADPH => 2 glutathione + NADP(+)"}
{"X":15097,"RHEA_ID":11742,"DIRECTION":"RL","MASTER_ID":11740,"ecocyc":"GLUTATHIONE-REDUCT-NADPH-RXN","macie":"M0006","metacyc":"GLUTATHIONE-REDUCT-NADPH-RXN","reactome":"R-HSA-3323079.1","compounds":"glutathione disulfide + H(+) + NADPH => 2 glutathione + NADP(+)"}
{"X":15098,"RHEA_ID":21580,"DIRECTION":"UN","MASTER_ID":21580,"ec":"4.1.1.5","compounds":"(2S)-2-acetolactate + H(+) = (R)-acetoin + CO2"}
{"X":15099,"RHEA_ID":11744,"DIRECTION":"UN","MASTER_ID":11744,"ec":"3.6.1.28","compounds":"H2O + thiamine triphosphate = H(+) + phosphate + thiamine diphosphate"}
{"X":15100,"RHEA_ID":11745,"DIRECTION":"LR","MASTER_ID":11744,"metacyc":"THIAMIN-TRIPHOSPHATASE-RXN","reactome":"R-HSA-965067.1","compounds":"H2O + thiamine triphosphate => H(+) + phosphate + thiamine diphosphate"}
{"X":15101,"RHEA_ID":11746,"compounds":"H(+) + phosphate + thiamine diphosphate => H2O + thiamine triphosphate"}
{"X":15102,"RHEA_ID":21584,"DIRECTION":"UN","MASTER_ID":21584,"ec":"1.1.1.7","metacyc":"PROPANEDIOL-PHOSPHATE-DEHYDROGENASE-RXN","compounds":"NAD(+) + propane-1,2-diol 1-phosphate = H(+) + hydroxyacetone phosphate + NADH"}
{"X":15103,"RHEA_ID":11748,"DIRECTION":"UN","MASTER_ID":11748,"ec":"2.2.1.8","compounds":"fluoroacetaldehyde + L-threonine = 4-fluoro-L-threonine + acetaldehyde"}
{"X":15104,"RHEA_ID":11749,"DIRECTION":"LR","MASTER_ID":11748,"metacyc":"RXN-11747","compounds":"fluoroacetaldehyde + L-threonine => 4-fluoro-L-threonine + acetaldehyde"}
{"X":15105,"RHEA_ID":11750,"compounds":"4-fluoro-L-threonine + acetaldehyde => fluoroacetaldehyde + L-threonine"}
{"X":15106,"RHEA_ID":21588,"DIRECTION":"UN","MASTER_ID":21588,"ec":"1.2.1.38","compounds":"N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH"}
{"X":15107,"RHEA_ID":11752,"DIRECTION":"UN","MASTER_ID":11752,"ec":"3.1.1.55","compounds":"acetylsalicylate + H2O = acetate + H(+) + salicylate"}
{"X":15108,"RHEA_ID":11753,"DIRECTION":"LR","MASTER_ID":11752,"metacyc":"ACETYLSALICYLATE-DEACETYLASE-RXN","compounds":"acetylsalicylate + H2O => acetate + H(+) + salicylate"}
{"X":15109,"RHEA_ID":11754,"compounds":"acetate + H(+) + salicylate => acetylsalicylate + H2O"}
{"X":15110,"RHEA_ID":21592,"DIRECTION":"UN","MASTER_ID":21592,"ec":"1.5.1.28","compounds":"(2S)-2-[(R)-1-carboxyethylamino]pentanoate + H2O + NAD(+) = H(+) + L-2-aminopentanoate + NADH + pyruvate"}
{"X":15111,"RHEA_ID":11756,"DIRECTION":"UN","MASTER_ID":11756,"ec":"6.3.4.15","compounds":"ATP + biotin + L-lysyl-[protein] = AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein]"}
{"X":15112,"RHEA_ID":11757,"DIRECTION":"LR","MASTER_ID":11756,"ecocyc":"BIOTINLIG-RXN","metacyc":"BIOTINLIG-RXN","compounds":"ATP + biotin + L-lysyl-[protein] => AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein]"}
{"X":15113,"RHEA_ID":11758,"compounds":"AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein] => ATP + biotin + L-lysyl-[protein]"}
{"X":15114,"RHEA_ID":21596,"compounds":"L-serine + NADP(+) = 2-aminomalonate semialdehyde + H(+) + NADPH"}
{"X":15115,"RHEA_ID":11760,"compounds":"4 ATP + citrate + 2 H2O + 2 N(6)-acetyl-N(6)-hydroxy-L-lysine = 4 ADP + aerobactin + 4 H(+) + 4 phosphate"}
{"X":15116,"RHEA_ID":11761,"DIRECTION":"LR","MASTER_ID":11760,"metacyc":"6.3.2.27-RXN","compounds":"4 ATP + citrate + 2 H2O + 2 N(6)-acetyl-N(6)-hydroxy-L-lysine => 4 ADP + aerobactin + 4 H(+) + 4 phosphate"}
{"X":15117,"RHEA_ID":11762,"compounds":"4 ADP + aerobactin + 4 H(+) + 4 phosphate => 4 ATP + citrate + 2 H2O + 2 N(6)-acetyl-N(6)-hydroxy-L-lysine"}
{"X":15118,"RHEA_ID":11764,"DIRECTION":"UN","MASTER_ID":11764,"ec":"3.5.3.16","compounds":"H2O + methylguanidine = methylamine + urea"}
{"X":15119,"RHEA_ID":11765,"DIRECTION":"LR","MASTER_ID":11764,"metacyc":"METHYLGUANIDINASE-RXN","compounds":"H2O + methylguanidine => methylamine + urea"}
{"X":15120,"RHEA_ID":11766,"compounds":"methylamine + urea => H2O + methylguanidine"}
{"X":15121,"RHEA_ID":11768,"DIRECTION":"UN","MASTER_ID":11768,"ec":"2.4.2.18","compounds":"diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate"}
{"X":15122,"RHEA_ID":11769,"compounds":"diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate => 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate"}
{"X":15123,"RHEA_ID":11770,"DIRECTION":"RL","MASTER_ID":11768,"ecocyc":"PRTRANS-RXN","compounds":"5-phospho-alpha-D-ribose 1-diphosphate + anthranilate => diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate"}
{"X":15124,"RHEA_ID":21608,"DIRECTION":"UN","MASTER_ID":21608,"ec":"2.1.1.154","compounds":"isoliquiritigenin + S-adenosyl-L-methionine = 2'-O-methylisoliquiritigenin + S-adenosyl-L-homocysteine"}
{"X":15125,"RHEA_ID":11772,"DIRECTION":"UN","MASTER_ID":11772,"ec":"1.1.1.220","compounds":"6-lactoyl-5,6,7,8-tetrahydropterin + NADP(+) = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH"}
{"X":15126,"RHEA_ID":11773,"compounds":"6-lactoyl-5,6,7,8-tetrahydropterin + NADP(+) => 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH"}
{"X":15127,"RHEA_ID":11774,"DIRECTION":"RL","MASTER_ID":11772,"metacyc":"1.1.1.220-RXN","compounds":"6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH => 6-lactoyl-5,6,7,8-tetrahydropterin + NADP(+)"}
{"X":15128,"RHEA_ID":21612,"DIRECTION":"UN","MASTER_ID":21612,"ec":"4.2.1.39","compounds":"D-gluconate = 2-dehydro-3-deoxy-D-gluconate + H2O"}
{"X":15129,"RHEA_ID":11776,"DIRECTION":"UN","MASTER_ID":11776,"ec":"1.14.19.2","compounds":"2 H(+) + O2 + octadecanoyl-[ACP] + 2 reduced [2Fe-2S]-[ferredoxin] = (9Z)-octadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":15130,"RHEA_ID":11777,"DIRECTION":"LR","MASTER_ID":11776,"metacyc":"RXN-7903","compounds":"2 H(+) + O2 + octadecanoyl-[ACP] + 2 reduced [2Fe-2S]-[ferredoxin] => (9Z)-octadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":15131,"RHEA_ID":11778,"compounds":"(9Z)-octadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + octadecanoyl-[ACP] + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":15132,"RHEA_ID":11780,"DIRECTION":"UN","MASTER_ID":11780,"ec":"2.4.1.134","compounds":"3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose = 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP"}
{"X":15133,"RHEA_ID":11781,"DIRECTION":"LR","MASTER_ID":11780,"metacyc":"2.4.1.134-RXN","compounds":"3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose => 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP"}
{"X":15134,"RHEA_ID":11782,"compounds":"3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose"}
{"X":15135,"RHEA_ID":11784,"DIRECTION":"UN","MASTER_ID":11784,"ec":"1.4.1.21","compounds":"H2O + L-aspartate + NADP(+) = H(+) + NADPH + NH4(+) + oxaloacetate"}
{"X":15136,"RHEA_ID":11785,"compounds":"H2O + L-aspartate + NADP(+) => H(+) + NADPH + NH4(+) + oxaloacetate"}
{"X":15137,"RHEA_ID":11786,"compounds":"H(+) + NADPH + NH4(+) + oxaloacetate => H2O + L-aspartate + NADP(+)"}
{"X":15138,"RHEA_ID":21622,"DIRECTION":"RL","MASTER_ID":21620,"ecocyc":"FMNREDUCT-RXN","metacyc":"FMNREDUCT-RXN","compounds":"FMN + 2 H(+) + NADH => FMNH2 + NAD(+)"}
{"X":15139,"RHEA_ID":11788,"DIRECTION":"UN","MASTER_ID":11788,"ec":"1.4.1.21","compounds":"H2O + L-aspartate + NAD(+) = H(+) + NADH + NH4(+) + oxaloacetate"}
{"X":15140,"RHEA_ID":11789,"compounds":"H2O + L-aspartate + NAD(+) => H(+) + NADH + NH4(+) + oxaloacetate"}
{"X":15141,"RHEA_ID":11790,"compounds":"H(+) + NADH + NH4(+) + oxaloacetate => H2O + L-aspartate + NAD(+)"}
{"X":15142,"RHEA_ID":21625,"compounds":"FMNH2 + NADP(+) => FMN + 2 H(+) + NADPH"}
{"X":15143,"RHEA_ID":11792,"DIRECTION":"UN","MASTER_ID":11792,"ec":"1.14.13.69","compounds":"H(+) + NADH + O2 + propene = 1,2-epoxypropane + H2O + NAD(+)"}
{"X":15144,"RHEA_ID":11793,"DIRECTION":"LR","MASTER_ID":11792,"metacyc":"RXN-9957","compounds":"H(+) + NADH + O2 + propene => 1,2-epoxypropane + H2O + NAD(+)"}
{"X":15145,"RHEA_ID":11794,"compounds":"1,2-epoxypropane + H2O + NAD(+) => H(+) + NADH + O2 + propene"}
{"X":15146,"RHEA_ID":11796,"DIRECTION":"UN","MASTER_ID":11796,"ec":"1.1.3.16","compounds":"ecdysone + O2 = 3-dehydroecdysone + H2O2"}
{"X":15147,"RHEA_ID":11797,"DIRECTION":"LR","MASTER_ID":11796,"metacyc":"ECDYSONE-OXIDASE-RXN","compounds":"ecdysone + O2 => 3-dehydroecdysone + H2O2"}
{"X":15148,"RHEA_ID":11798,"compounds":"3-dehydroecdysone + H2O2 => ecdysone + O2"}
{"X":15149,"RHEA_ID":21630,"compounds":"acetate + androst-4-ene-3,17-dione + H2O + NADP(+) => 17alpha-hydroxyprogesterone + NADPH + O2"}
{"X":15150,"RHEA_ID":11800,"DIRECTION":"UN","MASTER_ID":11800,"ec":"3.6.1.22","compounds":"H2O + NAD(+) = AMP + beta-nicotinamide D-ribonucleotide + 2 H(+)"}
{"X":15151,"RHEA_ID":11801,"DIRECTION":"LR","MASTER_ID":11800,"ecocyc":"NADPYROPHOSPHAT-RXN","metacyc":"NADPYROPHOSPHAT-RXN","compounds":"H2O + NAD(+) => AMP + beta-nicotinamide D-ribonucleotide + 2 H(+)"}
{"X":15152,"RHEA_ID":11802,"compounds":"AMP + beta-nicotinamide D-ribonucleotide + 2 H(+) => H2O + NAD(+)"}
{"X":15153,"RHEA_ID":21634,"compounds":"2 1,2-benzoquinone + 2 H2O => 2 catechol + O2"}
{"X":15154,"RHEA_ID":11804,"DIRECTION":"UN","MASTER_ID":11804,"ec":"1.2.1.29","metacyc":"ARYL-ALDEHYDE-DEHYDROGENASE-RXN","compounds":"an aromatic aldehyde + H2O + NAD(+) = an aromatic carboxylate + 2 H(+) + NADH"}
{"X":15155,"RHEA_ID":11805,"compounds":"an aromatic aldehyde + H2O + NAD(+) => an aromatic carboxylate + 2 H(+) + NADH"}
{"X":15156,"RHEA_ID":11806,"compounds":"an aromatic carboxylate + 2 H(+) + NADH => an aromatic aldehyde + H2O + NAD(+)"}
{"X":15157,"RHEA_ID":21638,"compounds":"4-O-(beta-D-glucosyl)-trans-4-coumarate + H(+) + UDP => trans-4-coumarate + UDP-alpha-D-glucose"}
{"X":15158,"RHEA_ID":11808,"DIRECTION":"UN","MASTER_ID":11808,"ec":"2.1.1.69","compounds":"bergaptol + S-adenosyl-L-methionine = bergapten + S-adenosyl-L-homocysteine"}
{"X":15159,"RHEA_ID":11809,"DIRECTION":"LR","MASTER_ID":11808,"metacyc":"2.1.1.69-RXN","compounds":"bergaptol + S-adenosyl-L-methionine => bergapten + S-adenosyl-L-homocysteine"}
{"X":15160,"RHEA_ID":11810,"compounds":"bergapten + S-adenosyl-L-homocysteine => bergaptol + S-adenosyl-L-methionine"}
{"X":15161,"RHEA_ID":21642,"compounds":"3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH => NADP(+) + prephenate"}
{"X":15162,"RHEA_ID":11812,"DIRECTION":"UN","MASTER_ID":11812,"ec":"1.8.3.4","compounds":"H2O + methanethiol + O2 = formaldehyde + H(+) + H2O2 + hydrogen sulfide"}
{"X":15163,"RHEA_ID":11813,"DIRECTION":"LR","MASTER_ID":11812,"metacyc":"METHANETHIOL-OXIDASE-RXN","compounds":"H2O + methanethiol + O2 => formaldehyde + H(+) + H2O2 + hydrogen sulfide"}
{"X":15164,"RHEA_ID":11814,"compounds":"formaldehyde + H(+) + H2O2 + hydrogen sulfide => H2O + methanethiol + O2"}
{"X":15165,"RHEA_ID":11816,"DIRECTION":"UN","MASTER_ID":11816,"ec":"5.3.1.9","compounds":"aldehydo-D-glucose 6-phosphate = keto-D-fructose 6-phosphate"}
{"X":15166,"RHEA_ID":11817,"compounds":"aldehydo-D-glucose 6-phosphate => keto-D-fructose 6-phosphate"}
{"X":15167,"RHEA_ID":11818,"compounds":"keto-D-fructose 6-phosphate => aldehydo-D-glucose 6-phosphate"}
{"X":15168,"RHEA_ID":21650,"compounds":"3-phenylpyruvate + CO2 + H2O => H(+) + prephenate"}
{"X":15169,"RHEA_ID":11820,"DIRECTION":"UN","MASTER_ID":11820,"ec":"2.4.2.36","compounds":"diphthamide-[translation elongation factor 2] + NAD(+) = H(+) + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2] + nicotinamide"}
{"X":15170,"RHEA_ID":11821,"compounds":"diphthamide-[translation elongation factor 2] + NAD(+) => H(+) + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2] + nicotinamide"}
{"X":15171,"RHEA_ID":11822,"compounds":"H(+) + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2] + nicotinamide => diphthamide-[translation elongation factor 2] + NAD(+)"}
{"X":15172,"RHEA_ID":21654,"compounds":"catechol + chloride + CO2 + NAD(+) => 2-chlorobenzoate + H(+) + NADH + O2"}
{"X":15173,"RHEA_ID":11824,"DIRECTION":"UN","MASTER_ID":11824,"ec":"2.1.2.11","compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate"}
{"X":15174,"RHEA_ID":11825,"compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O => (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate"}
{"X":15175,"RHEA_ID":11826,"compounds":"(6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O"}
{"X":15176,"RHEA_ID":21658,"compounds":"CDP-3,6-dideoxy-alpha-D-mannose => CDP-alpha-D-paratose"}
{"X":15177,"RHEA_ID":11828,"DIRECTION":"UN","MASTER_ID":11828,"ec":"3.1.4.58","compounds":"H2O + RNA(n)-2',3'-cyclic phosphate = H(+) + RNA(n)-2'- phosphate"}
{"X":15178,"RHEA_ID":11829,"DIRECTION":"LR","MASTER_ID":11828,"ecocyc":"RXN-15952","metacyc":"RXN-15952","compounds":"H2O + RNA(n)-2',3'-cyclic phosphate => H(+) + RNA(n)-2'- phosphate"}
{"X":15179,"RHEA_ID":11830,"compounds":"H(+) + RNA(n)-2'- phosphate => H2O + RNA(n)-2',3'-cyclic phosphate"}
{"X":15180,"RHEA_ID":11832,"DIRECTION":"UN","MASTER_ID":11832,"ec":"1.3.1.29","compounds":"(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+) = H(+) + NADH + naphthalene-1,2-diol"}
{"X":15181,"RHEA_ID":11833,"DIRECTION":"LR","MASTER_ID":11832,"metacyc":"1.3.1.29-RXN","compounds":"(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+) => H(+) + NADH + naphthalene-1,2-diol"}
{"X":15182,"RHEA_ID":11834,"compounds":"H(+) + NADH + naphthalene-1,2-diol => (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+)"}
{"X":15183,"RHEA_ID":21666,"compounds":"4-nitrophenol + H(+) + phosphate => 4-nitrophenyl phosphate + H2O"}
{"X":15184,"RHEA_ID":11836,"DIRECTION":"UN","MASTER_ID":11836,"ec":"2.4.99.1","compounds":"CMP-N-acetyl-beta-neuraminate + N-acetyllactosamine = CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine"}
{"X":15185,"RHEA_ID":11837,"DIRECTION":"LR","MASTER_ID":11836,"metacyc":"RXN-15271","compounds":"CMP-N-acetyl-beta-neuraminate + N-acetyllactosamine => CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine"}
{"X":15186,"RHEA_ID":11838,"compounds":"CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine => CMP-N-acetyl-beta-neuraminate + N-acetyllactosamine"}
{"X":15187,"RHEA_ID":21670,"compounds":"ADP + H(+) + phosphate + sn-glycerol 3-phosphate(in) => ATP + H2O + sn-glycerol 3-phosphate(out)"}
{"X":15188,"RHEA_ID":11840,"DIRECTION":"UN","MASTER_ID":11840,"ec":"1.2.1.28","compounds":"benzaldehyde + H2O + NAD(+) = benzoate + 2 H(+) + NADH"}
{"X":15189,"RHEA_ID":11841,"compounds":"benzaldehyde + H2O + NAD(+) => benzoate + 2 H(+) + NADH"}
{"X":15190,"RHEA_ID":11842,"compounds":"benzoate + 2 H(+) + NADH => benzaldehyde + H2O + NAD(+)"}
{"X":15191,"RHEA_ID":21674,"compounds":"[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine => [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine"}
{"X":15192,"RHEA_ID":11844,"DIRECTION":"UN","MASTER_ID":11844,"ec":"2.3.1.54","compounds":"acetyl-CoA + formate = CoA + pyruvate"}
{"X":15193,"RHEA_ID":11845,"compounds":"acetyl-CoA + formate => CoA + pyruvate"}
{"X":15194,"RHEA_ID":11846,"DIRECTION":"RL","MASTER_ID":11844,"ecocyc":"PYRUVFORMLY-RXN","macie":"M0030","compounds":"CoA + pyruvate => acetyl-CoA + formate"}
{"X":15195,"RHEA_ID":21678,"compounds":"(R)-lavandulyl diphosphate + diphosphate => 2 dimethylallyl diphosphate"}
{"X":15196,"RHEA_ID":11848,"DIRECTION":"UN","MASTER_ID":11848,"ec":"1.21.4.4","compounds":"[thioredoxin]-disulfide + acetyl phosphate + H2O + trimethylamine = [thioredoxin]-dithiol + betaine + H(+) + phosphate"}
{"X":15197,"RHEA_ID":11849,"compounds":"[thioredoxin]-disulfide + acetyl phosphate + H2O + trimethylamine => [thioredoxin]-dithiol + betaine + H(+) + phosphate"}
{"X":15198,"RHEA_ID":11850,"compounds":"[thioredoxin]-dithiol + betaine + H(+) + phosphate => [thioredoxin]-disulfide + acetyl phosphate + H2O + trimethylamine"}
{"X":15199,"RHEA_ID":21682,"compounds":"2-oxophytanate + H2O2 => (2S)-2-hydroxyphytanate + O2"}
{"X":15200,"RHEA_ID":11852,"DIRECTION":"UN","MASTER_ID":11852,"ec":"2.4.2.28","compounds":"phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate"}
{"X":15201,"RHEA_ID":11853,"DIRECTION":"LR","MASTER_ID":11852,"metacyc":"5-METHYLTHIOADENOSINE-PHOSPHORYLASE-RXN","reactome":"R-HSA-1237160.1","compounds":"phosphate + S-methyl-5'-thioadenosine => adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate"}
{"X":15202,"RHEA_ID":11854,"compounds":"adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate => phosphate + S-methyl-5'-thioadenosine"}
{"X":15203,"RHEA_ID":21686,"DIRECTION":"RL","MASTER_ID":21684,"metacyc":"BETA-ALANOPINE-DEHYDROGENASE-RXN","compounds":"beta-alanine + H(+) + NADH + pyruvate => (R)-beta-alanopine + H2O + NAD(+)"}
{"X":15204,"RHEA_ID":11856,"compounds":"1D-myo-inositol 1,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)"}
{"X":15205,"RHEA_ID":11857,"DIRECTION":"LR","MASTER_ID":11856,"metacyc":"RXN-7162","reactome":"R-HSA-1855185.2","compounds":"1D-myo-inositol 1,4,5,6-tetrakisphosphate + ATP => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)"}
{"X":15206,"RHEA_ID":11858,"compounds":"1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+) => 1D-myo-inositol 1,4,5,6-tetrakisphosphate + ATP"}
{"X":15207,"RHEA_ID":21690,"compounds":"an oxidized polyvinyl alcohol + n H2O2 => a polyvinyl alcohol + n O2"}
{"X":15208,"RHEA_ID":11860,"DIRECTION":"UN","MASTER_ID":11860,"ec":"2.7.13.2","compounds":"ATP + L-histidyl-[protein] = ADP + H(+) + N(tele)-phospho-L-histidyl-[protein]"}
{"X":15209,"RHEA_ID":11861,"DIRECTION":"LR","MASTER_ID":11860,"ecocyc":"2.7.13.2-RXN","metacyc":"2.7.13.2-RXN","compounds":"ATP + L-histidyl-[protein] => ADP + H(+) + N(tele)-phospho-L-histidyl-[protein]"}
{"X":15210,"RHEA_ID":11862,"compounds":"ADP + H(+) + N(tele)-phospho-L-histidyl-[protein] => ATP + L-histidyl-[protein]"}
{"X":15211,"RHEA_ID":21694,"compounds":"CMP + 2 H(+) + sn-glycerol 3-phosphate => CDP-glycerol + H2O"}
{"X":15212,"RHEA_ID":11864,"DIRECTION":"UN","MASTER_ID":11864,"ec":"1.5.8.2","compounds":"H(+) + H2O + oxidized [electron-transfer flavoprotein] + trimethylamine = dimethylamine + formaldehyde + reduced [electron-transfer flavoprotein]"}
{"X":15213,"RHEA_ID":11865,"compounds":"H(+) + H2O + oxidized [electron-transfer flavoprotein] + trimethylamine => dimethylamine + formaldehyde + reduced [electron-transfer flavoprotein]"}
{"X":15214,"RHEA_ID":11866,"compounds":"dimethylamine + formaldehyde + reduced [electron-transfer flavoprotein] => H(+) + H2O + oxidized [electron-transfer flavoprotein] + trimethylamine"}
{"X":15215,"RHEA_ID":11868,"DIRECTION":"UN","MASTER_ID":11868,"ec":"1.1.1.287","compounds":"D-arabinitol + NADP(+) = D-ribulose + H(+) + NADPH"}
{"X":15216,"RHEA_ID":11869,"compounds":"D-arabinitol + NADP(+) => D-ribulose + H(+) + NADPH"}
{"X":15217,"RHEA_ID":11870,"compounds":"D-ribulose + H(+) + NADPH => D-arabinitol + NADP(+)"}
{"X":15218,"RHEA_ID":21702,"compounds":"1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate => 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O"}
{"X":15219,"RHEA_ID":11872,"DIRECTION":"UN","MASTER_ID":11872,"ec":"1.14.15.5","compounds":"corticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 18-hydroxycorticosterone + H2O + 2 oxidized [adrenodoxin]"}
{"X":15220,"RHEA_ID":11873,"DIRECTION":"LR","MASTER_ID":11872,"metacyc":"CORTICOSTERONE-18-MONOOXYGENASE-RXN","compounds":"corticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 18-hydroxycorticosterone + H2O + 2 oxidized [adrenodoxin]"}
{"X":15221,"RHEA_ID":11874,"compounds":"18-hydroxycorticosterone + H2O + 2 oxidized [adrenodoxin] => corticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}
{"X":15222,"RHEA_ID":21706,"compounds":"NH4(+) + phenol + pyruvate => H2O + L-tyrosine"}
{"X":15223,"RHEA_ID":11876,"DIRECTION":"UN","MASTER_ID":11876,"ec":"1.1.1.141","compounds":"NAD(+) + prostaglandin E2 = 15-oxo-prostaglandin E2 + H(+) + NADH"}
{"X":15224,"RHEA_ID":11877,"DIRECTION":"LR","MASTER_ID":11876,"reactome":"R-HSA-2161662.2","compounds":"NAD(+) + prostaglandin E2 => 15-oxo-prostaglandin E2 + H(+) + NADH"}
{"X":15225,"RHEA_ID":11878,"compounds":"15-oxo-prostaglandin E2 + H(+) + NADH => NAD(+) + prostaglandin E2"}
{"X":15226,"RHEA_ID":21710,"compounds":"adenosine + L-homocysteine => H2O + S-adenosyl-L-homocysteine"}
{"X":15227,"RHEA_ID":11880,"DIRECTION":"UN","MASTER_ID":11880,"ec":"1.5.3.5","compounds":"(S)-6-hydroxynicotine + H2O + O2 = 6-hydroxypseudooxynicotine + H2O2"}
{"X":15228,"RHEA_ID":11881,"DIRECTION":"LR","MASTER_ID":11880,"metacyc":"S-6-HYDROXYNICOTINE-OXIDASE-RXN","compounds":"(S)-6-hydroxynicotine + H2O + O2 => 6-hydroxypseudooxynicotine + H2O2"}
{"X":15229,"RHEA_ID":11882,"compounds":"6-hydroxypseudooxynicotine + H2O2 => (S)-6-hydroxynicotine + H2O + O2"}
{"X":15230,"RHEA_ID":21714,"compounds":"benzaldehyde + glycine => L-threo-3-phenylserine"}
{"X":15231,"RHEA_ID":11884,"DIRECTION":"UN","MASTER_ID":11884,"ec":"2.8.2.18","compounds":"3'-phosphoadenylyl sulfate + cortisol = adenosine 3',5'-bisphosphate + cortisol 21-sulfate + H(+)"}
{"X":15232,"RHEA_ID":11885,"compounds":"3'-phosphoadenylyl sulfate + cortisol => adenosine 3',5'-bisphosphate + cortisol 21-sulfate + H(+)"}
{"X":15233,"RHEA_ID":11886,"compounds":"adenosine 3',5'-bisphosphate + cortisol 21-sulfate + H(+) => 3'-phosphoadenylyl sulfate + cortisol"}
{"X":15234,"RHEA_ID":21718,"compounds":"(6R)-L-erythro-6,7-dihydrobiopterin + (S)-4-hydroxymandelate + H2O => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + (S)-mandelate + O2"}
{"X":15235,"RHEA_ID":11888,"DIRECTION":"UN","MASTER_ID":11888,"ec":"1.2.1.5","metacyc":"ALDEHYDE-DEHYDROGENASE-NADORNOP%252b-RXN","compounds":"an aldehyde + H2O + NADP(+) = a carboxylate + 2 H(+) + NADPH"}
{"X":15236,"RHEA_ID":11888,"DIRECTION":"UN","MASTER_ID":11888,"ec":"1.2.1.4","metacyc":"ALDEHYDE-DEHYDROGENASE-NADORNOP%252b-RXN","compounds":"an aldehyde + H2O + NADP(+) = a carboxylate + 2 H(+) + NADPH"}
{"X":15237,"RHEA_ID":11889,"compounds":"an aldehyde + H2O + NADP(+) => a carboxylate + 2 H(+) + NADPH"}
{"X":15238,"RHEA_ID":11890,"compounds":"a carboxylate + 2 H(+) + NADPH => an aldehyde + H2O + NADP(+)"}
{"X":15239,"RHEA_ID":11892,"DIRECTION":"UN","MASTER_ID":11892,"ec":"2.1.1.121","compounds":"6-O-methylnorlaudanosoline + S-adenosyl-L-methionine = H(+) + nororientaline + S-adenosyl-L-homocysteine"}
{"X":15240,"RHEA_ID":11893,"DIRECTION":"LR","MASTER_ID":11892,"metacyc":"2.1.1.121-RXN","compounds":"6-O-methylnorlaudanosoline + S-adenosyl-L-methionine => H(+) + nororientaline + S-adenosyl-L-homocysteine"}
{"X":15241,"RHEA_ID":11894,"compounds":"H(+) + nororientaline + S-adenosyl-L-homocysteine => 6-O-methylnorlaudanosoline + S-adenosyl-L-methionine"}
{"X":15242,"RHEA_ID":11896,"DIRECTION":"UN","MASTER_ID":11896,"ec":"1.1.1.181","compounds":"7alpha-hydroxycholesterol + NAD(+) = 7alpha-hydroxycholest-4-en-3-one + H(+) + NADH"}
{"X":15243,"RHEA_ID":11897,"DIRECTION":"LR","MASTER_ID":11896,"metacyc":"1.1.1.181-RXN","compounds":"7alpha-hydroxycholesterol + NAD(+) => 7alpha-hydroxycholest-4-en-3-one + H(+) + NADH"}
{"X":15244,"RHEA_ID":11898,"compounds":"7alpha-hydroxycholest-4-en-3-one + H(+) + NADH => 7alpha-hydroxycholesterol + NAD(+)"}
{"X":15245,"RHEA_ID":32308,"DIRECTION":"LR","MASTER_ID":32307,"metacyc":"RXN-13395","compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => H2O + leukotriene A4"}
{"X":15246,"RHEA_ID":11900,"DIRECTION":"UN","MASTER_ID":11900,"ec":"1.1.1.87","compounds":"(1R,2S)-homoisocitrate + NAD(+) = 2-oxoadipate + CO2 + NADH"}
{"X":15247,"RHEA_ID":11900,"DIRECTION":"UN","MASTER_ID":11900,"ec":"1.1.1.286","compounds":"(1R,2S)-homoisocitrate + NAD(+) = 2-oxoadipate + CO2 + NADH"}
{"X":15248,"RHEA_ID":11901,"DIRECTION":"LR","MASTER_ID":11900,"metacyc":"1.1.1.87-RXN","compounds":"(1R,2S)-homoisocitrate + NAD(+) => 2-oxoadipate + CO2 + NADH"}
{"X":15249,"RHEA_ID":11901,"DIRECTION":"LR","MASTER_ID":11900,"metacyc":"RXN-7970","compounds":"(1R,2S)-homoisocitrate + NAD(+) => 2-oxoadipate + CO2 + NADH"}
{"X":15250,"RHEA_ID":11902,"compounds":"2-oxoadipate + CO2 + NADH => (1R,2S)-homoisocitrate + NAD(+)"}
{"X":15251,"RHEA_ID":21737,"DIRECTION":"LR","MASTER_ID":21736,"metacyc":"BETA-LYSINE-56-AMINOMUTASE-RXN","compounds":"(3S)-3,6-diaminohexanoate => (3S,5S)-3,5-diaminohexanoate"}
{"X":15252,"RHEA_ID":11904,"DIRECTION":"UN","MASTER_ID":11904,"ec":"3.5.4.11","compounds":"2-amino-4-hydroxypteridine + H(+) + H2O = 2,4-dihydroxypteridine + NH4(+)"}
{"X":15253,"RHEA_ID":11905,"compounds":"2-amino-4-hydroxypteridine + H(+) + H2O => 2,4-dihydroxypteridine + NH4(+)"}
{"X":15254,"RHEA_ID":11906,"compounds":"2,4-dihydroxypteridine + NH4(+) => 2-amino-4-hydroxypteridine + H(+) + H2O"}
{"X":15255,"RHEA_ID":21741,"DIRECTION":"LR","MASTER_ID":21740,"ecocyc":"MERCAPYSTRANS-RXN","metacyc":"MERCAPYSTRANS-RXN","compounds":"3-mercaptopyruvate + [thioredoxin]-dithiol => [thioredoxin]-disulfide + H(+) + hydrogen sulfide + pyruvate"}
{"X":15256,"RHEA_ID":11908,"DIRECTION":"UN","MASTER_ID":11908,"ec":"3.7.1.7","compounds":"H2O + nonane-4,6-dione = butanoate + H(+) + pentan-2-one"}
{"X":15257,"RHEA_ID":11909,"compounds":"H2O + nonane-4,6-dione => butanoate + H(+) + pentan-2-one"}
{"X":15258,"RHEA_ID":11910,"compounds":"butanoate + H(+) + pentan-2-one => H2O + nonane-4,6-dione"}
{"X":15259,"RHEA_ID":11912,"DIRECTION":"UN","MASTER_ID":11912,"ec":"1.3.1.48","compounds":"13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+) = 15-oxo-prostaglandin E2 + H(+) + NADPH"}
{"X":15260,"RHEA_ID":11913,"compounds":"13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+) => 15-oxo-prostaglandin E2 + H(+) + NADPH"}
{"X":15261,"RHEA_ID":11914,"compounds":"15-oxo-prostaglandin E2 + H(+) + NADPH => 13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+)"}
{"X":15262,"RHEA_ID":21749,"compounds":"(S)-lactaldehyde + NADP(+) => H(+) + methylglyoxal + NADPH"}
{"X":15263,"RHEA_ID":11916,"DIRECTION":"UN","MASTER_ID":11916,"ec":"1.3.1.48","compounds":"13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+) = 15-oxo-prostaglandin E2 + H(+) + NADH"}
{"X":15264,"RHEA_ID":11917,"compounds":"13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+) => 15-oxo-prostaglandin E2 + H(+) + NADH"}
{"X":15265,"RHEA_ID":11918,"compounds":"15-oxo-prostaglandin E2 + H(+) + NADH => 13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+)"}
{"X":15266,"RHEA_ID":21753,"DIRECTION":"LR","MASTER_ID":21752,"metacyc":"RXN-7946","compounds":"all-trans-violaxanthin => all-trans-capsorubin"}
{"X":15267,"RHEA_ID":11920,"DIRECTION":"UN","MASTER_ID":11920,"ec":"4.2.1.96","compounds":"(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O"}
{"X":15268,"RHEA_ID":11921,"DIRECTION":"LR","MASTER_ID":11920,"metacyc":"RXN-7908","compounds":"(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin => (6R)-L-erythro-6,7-dihydrobiopterin + H2O"}
{"X":15269,"RHEA_ID":11922,"compounds":"(6R)-L-erythro-6,7-dihydrobiopterin + H2O => (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin"}
{"X":15270,"RHEA_ID":21757,"DIRECTION":"LR","MASTER_ID":21756,"metacyc":"4.3.3.3-RXN","compounds":"deacetylisoipecoside + H2O => dopamine + secologanin"}
{"X":15271,"RHEA_ID":11924,"DIRECTION":"UN","MASTER_ID":11924,"ec":"2.4.1.228","compounds":"a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = globoside Gb3Cer (d18:1(4E)) + H(+) + UDP"}
{"X":15272,"RHEA_ID":11925,"compounds":"a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose => globoside Gb3Cer (d18:1(4E)) + H(+) + UDP"}
{"X":15273,"RHEA_ID":11926,"compounds":"globoside Gb3Cer (d18:1(4E)) + H(+) + UDP => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose"}
{"X":15274,"RHEA_ID":21761,"compounds":"(3S)-hydroxybutanoyl-CoA => (3R)-hydroxybutanoyl-CoA"}
{"X":15275,"RHEA_ID":11928,"compounds":"hydroxylamine + NH4(+) = H(+) + H2O + hydrazine"}
{"X":15276,"RHEA_ID":11929,"DIRECTION":"LR","MASTER_ID":11928,"metacyc":"RXN-3461","compounds":"hydroxylamine + NH4(+) => H(+) + H2O + hydrazine"}
{"X":15277,"RHEA_ID":11930,"compounds":"H(+) + H2O + hydrazine => hydroxylamine + NH4(+)"}
{"X":15278,"RHEA_ID":11931,"compounds":"hydroxylamine + NH4(+) <=> H(+) + H2O + hydrazine"}
{"X":15279,"RHEA_ID":11932,"compounds":"2-hydroxy-2-methylpropanenitrile = acetone + hydrogen cyanide"}
{"X":15280,"RHEA_ID":11933,"DIRECTION":"LR","MASTER_ID":11932,"macie":"M0217","metacyc":"ACETONE-CYANHYDRIN-LYASE-RXN","compounds":"2-hydroxy-2-methylpropanenitrile => acetone + hydrogen cyanide"}
{"X":15281,"RHEA_ID":11934,"compounds":"acetone + hydrogen cyanide => 2-hydroxy-2-methylpropanenitrile"}
{"X":15282,"RHEA_ID":11936,"DIRECTION":"UN","MASTER_ID":11936,"ec":"2.3.1.95","compounds":"4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA = 4 CO2 + 4 CoA + trans-resveratrol"}
{"X":15283,"RHEA_ID":11937,"DIRECTION":"LR","MASTER_ID":11936,"metacyc":"RXN-87","compounds":"4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA => 4 CO2 + 4 CoA + trans-resveratrol"}
{"X":15284,"RHEA_ID":11937,"DIRECTION":"LR","MASTER_ID":11936,"metacyc":"TRIHYDROXYSTILBENE-SYNTHASE-RXN","compounds":"4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA => 4 CO2 + 4 CoA + trans-resveratrol"}
{"X":15285,"RHEA_ID":11938,"compounds":"4 CO2 + 4 CoA + trans-resveratrol => 4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA"}
{"X":15286,"RHEA_ID":21774,"compounds":"NH4(+) + uridine(6666) in apoB mRNA => cytidine(6666) in apoB mRNA + H(+) + H2O"}
{"X":15287,"RHEA_ID":11940,"DIRECTION":"UN","MASTER_ID":11940,"ec":"3.5.1.20","compounds":"2 H(+) + H2O + L-citrulline = CO2 + L-ornithine + NH4(+)"}
{"X":15288,"RHEA_ID":11941,"DIRECTION":"LR","MASTER_ID":11940,"metacyc":"CITRULLINASE-RXN","compounds":"2 H(+) + H2O + L-citrulline => CO2 + L-ornithine + NH4(+)"}
{"X":15289,"RHEA_ID":11942,"compounds":"CO2 + L-ornithine + NH4(+) => 2 H(+) + H2O + L-citrulline"}
{"X":15290,"RHEA_ID":21778,"compounds":"(25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate => (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate + ATP + CoA"}
{"X":15291,"RHEA_ID":11944,"compounds":"(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + 2 H2O = 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + 2 chloride + 2 H(+)"}
{"X":15292,"RHEA_ID":11945,"compounds":"(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + 2 H2O => 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + 2 chloride + 2 H(+)"}
{"X":15293,"RHEA_ID":11946,"compounds":"2,5-dichlorocyclohexa-2,5-dien-1,4-diol + 2 chloride + 2 H(+) => (3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + 2 H2O"}
{"X":15294,"RHEA_ID":11947,"compounds":"(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + 2 H2O <=> 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + 2 chloride + 2 H(+)"}
{"X":15295,"RHEA_ID":11948,"DIRECTION":"UN","MASTER_ID":11948,"ec":"3.1.2.23","compounds":"4-hydroxybenzoyl-CoA + H2O = 4-hydroxybenzoate + CoA + H(+)"}
{"X":15296,"RHEA_ID":11949,"DIRECTION":"LR","MASTER_ID":11948,"metacyc":"3.1.2.23-RXN","compounds":"4-hydroxybenzoyl-CoA + H2O => 4-hydroxybenzoate + CoA + H(+)"}
{"X":15297,"RHEA_ID":11950,"compounds":"4-hydroxybenzoate + CoA + H(+) => 4-hydroxybenzoyl-CoA + H2O"}
{"X":15298,"RHEA_ID":21786,"compounds":"2 H(+) + L-threonate + oxalate => H2O + L-ascorbate + O2"}
{"X":15299,"RHEA_ID":11952,"DIRECTION":"UN","MASTER_ID":11952,"ec":"5.3.1.22","compounds":"3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate"}
{"X":15300,"RHEA_ID":11953,"compounds":"3-hydroxypyruvate => 2-hydroxy-3-oxopropanoate"}
{"X":15301,"RHEA_ID":11954,"compounds":"2-hydroxy-3-oxopropanoate => 3-hydroxypyruvate"}
{"X":15302,"RHEA_ID":21790,"compounds":"CO2 + formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + O2"}
{"X":15303,"RHEA_ID":11956,"DIRECTION":"UN","MASTER_ID":11956,"ec":"3.2.1.104","compounds":"cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose"}
{"X":15304,"RHEA_ID":11957,"DIRECTION":"LR","MASTER_ID":11956,"metacyc":"STERYL-BETA-GLUCOSIDASE-RXN","compounds":"cholesteryl 3-beta-D-glucoside + H2O => cholesterol + D-glucose"}
{"X":15305,"RHEA_ID":11958,"compounds":"cholesterol + D-glucose => cholesteryl 3-beta-D-glucoside + H2O"}
{"X":15306,"RHEA_ID":21794,"compounds":"acetone + H(+) + NADPH => NADP(+) + propan-2-ol"}
{"X":15307,"RHEA_ID":11960,"DIRECTION":"UN","MASTER_ID":11960,"ec":"2.6.1.17","compounds":"2-oxoglutarate + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate = (S)-2-succinylamino-6-oxoheptanedioate + L-glutamate"}
{"X":15308,"RHEA_ID":11961,"compounds":"2-oxoglutarate + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate => (S)-2-succinylamino-6-oxoheptanedioate + L-glutamate"}
{"X":15309,"RHEA_ID":11962,"compounds":"(S)-2-succinylamino-6-oxoheptanedioate + L-glutamate => 2-oxoglutarate + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate"}
{"X":15310,"RHEA_ID":21798,"compounds":"dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH => dTDP-beta-L-rhamnose + NADP(+)"}
{"X":15311,"RHEA_ID":11964,"DIRECTION":"UN","MASTER_ID":11964,"ec":"3.3.2.11","compounds":"5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O = 5alpha-cholestane-3beta,5,6beta-triol"}
{"X":15312,"RHEA_ID":11965,"compounds":"5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O => 5alpha-cholestane-3beta,5,6beta-triol"}
{"X":15313,"RHEA_ID":11966,"compounds":"5alpha-cholestane-3beta,5,6beta-triol => 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O"}
{"X":15314,"RHEA_ID":21802,"compounds":"all-trans-zeaxanthin + H2O + L-dehydroascorbate => all-trans-antheraxanthin + L-ascorbate"}
{"X":15315,"RHEA_ID":11968,"DIRECTION":"UN","MASTER_ID":11968,"ec":"1.14.99.2","compounds":"AH2 + kynurenate + O2 = 7,8-dihydro-7,8-dihydroxykynurenate + A"}
{"X":15316,"RHEA_ID":11969,"DIRECTION":"LR","MASTER_ID":11968,"metacyc":"KYNURENINE-78-HYDROXYLASE-RXN","compounds":"AH2 + kynurenate + O2 => 7,8-dihydro-7,8-dihydroxykynurenate + A"}
{"X":15317,"RHEA_ID":11970,"compounds":"7,8-dihydro-7,8-dihydroxykynurenate + A => AH2 + kynurenate + O2"}
{"X":15318,"RHEA_ID":21806,"compounds":"1D-myo-inositol 3-phosphate + ADP + H(+) => ATP + myo-inositol"}
{"X":15319,"RHEA_ID":11972,"DIRECTION":"UN","MASTER_ID":11972,"ec":"1.16.3.2","compounds":"4 Fe(2+) + 6 H2O + O2 = 12 H(+) + 4 iron(III) oxide-hydroxide"}
{"X":15320,"RHEA_ID":11973,"DIRECTION":"LR","MASTER_ID":11972,"ecocyc":"RXN-15294","metacyc":"RXN-15294","compounds":"4 Fe(2+) + 6 H2O + O2 => 12 H(+) + 4 iron(III) oxide-hydroxide"}
{"X":15321,"RHEA_ID":11974,"compounds":"12 H(+) + 4 iron(III) oxide-hydroxide => 4 Fe(2+) + 6 H2O + O2"}
{"X":15322,"RHEA_ID":11975,"compounds":"4 Fe(2+) + 6 H2O + O2 <=> 12 H(+) + 4 iron(III) oxide-hydroxide"}
{"X":15323,"RHEA_ID":11976,"DIRECTION":"UN","MASTER_ID":11976,"ec":"1.14.13.38","compounds":"anhydrotetracycline + H(+) + NADPH + O2 = 5a,11a-dehydrotetracycline + H2O + NADP(+)"}
{"X":15324,"RHEA_ID":11977,"DIRECTION":"LR","MASTER_ID":11976,"metacyc":"ANHYDROTETRACYCLINE-MONOOXYGENASE-RXN","compounds":"anhydrotetracycline + H(+) + NADPH + O2 => 5a,11a-dehydrotetracycline + H2O + NADP(+)"}
{"X":15325,"RHEA_ID":11978,"compounds":"5a,11a-dehydrotetracycline + H2O + NADP(+) => anhydrotetracycline + H(+) + NADPH + O2"}
{"X":15326,"RHEA_ID":21814,"compounds":"7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":15327,"RHEA_ID":11980,"DIRECTION":"UN","MASTER_ID":11980,"ec":"1.8.1.13","compounds":"2 L-gamma-glutamyl-L-cysteine + NADP(+) = bis-gamma-glutamylcystine + H(+) + NADPH"}
{"X":15328,"RHEA_ID":11981,"compounds":"2 L-gamma-glutamyl-L-cysteine + NADP(+) => bis-gamma-glutamylcystine + H(+) + NADPH"}
{"X":15329,"RHEA_ID":11982,"DIRECTION":"RL","MASTER_ID":11980,"metacyc":"1.6.4.9-RXN","compounds":"bis-gamma-glutamylcystine + H(+) + NADPH => 2 L-gamma-glutamyl-L-cysteine + NADP(+)"}
{"X":15330,"RHEA_ID":21818,"compounds":"a 2-oxocarboxylate + H2O2 + NH4(+) => a D-alpha-amino acid + H2O + O2"}
{"X":15331,"RHEA_ID":11984,"DIRECTION":"UN","MASTER_ID":11984,"ec":"1.14.99.4","compounds":"AH2 + O2 + progesterone = A + H2O + testosterone acetate"}
{"X":15332,"RHEA_ID":11985,"DIRECTION":"LR","MASTER_ID":11984,"metacyc":"PROGESTERONE-MONOOXYGENASE-RXN","compounds":"AH2 + O2 + progesterone => A + H2O + testosterone acetate"}
{"X":15333,"RHEA_ID":11986,"compounds":"A + H2O + testosterone acetate => AH2 + O2 + progesterone"}
{"X":15334,"RHEA_ID":21822,"compounds":"H(+) + L-methionine + S-adenosyl-L-homocysteine => L-homocysteine + S-adenosyl-L-methionine"}
{"X":15335,"RHEA_ID":11988,"DIRECTION":"UN","MASTER_ID":11988,"ec":"2.1.1.79","compounds":"1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine = 1-acyl-2-(9-cyclopronane)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine"}
{"X":15336,"RHEA_ID":11989,"DIRECTION":"LR","MASTER_ID":11988,"ecocyc":"2.1.1.79-RXN","metacyc":"2.1.1.79-RXN","compounds":"1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine => 1-acyl-2-(9-cyclopronane)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine"}
{"X":15337,"RHEA_ID":11990,"compounds":"1-acyl-2-(9-cyclopronane)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine => 1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine"}
{"X":15338,"RHEA_ID":21825,"DIRECTION":"LR","MASTER_ID":21824,"reactome":"R-HSA-70596.3","compounds":"2-oxoglutarate + L-aspartate => L-glutamate + oxaloacetate"}
{"X":15339,"RHEA_ID":11992,"DIRECTION":"UN","MASTER_ID":11992,"ec":"1.5.3.7","compounds":"L-pipecolate + O2 = H(+) + H2O2 + L-1-piperideine-6-carboxylate"}
{"X":15340,"RHEA_ID":11993,"DIRECTION":"LR","MASTER_ID":11992,"metacyc":"L-PIPECOLATE-OXIDASE-RXN","reactome":"R-HSA-6783880.1","compounds":"L-pipecolate + O2 => H(+) + H2O2 + L-1-piperideine-6-carboxylate"}
{"X":15341,"RHEA_ID":11994,"compounds":"H(+) + H2O2 + L-1-piperideine-6-carboxylate => L-pipecolate + O2"}
{"X":15342,"RHEA_ID":21828,"DIRECTION":"UN","MASTER_ID":21828,"ec":"1.7.7.2","compounds":"H2O + nitrite + 2 oxidized [2Fe-2S]-[ferredoxin] = 2 H(+) + nitrate + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":15343,"RHEA_ID":11996,"DIRECTION":"UN","MASTER_ID":11996,"ec":"1.14.13.44","compounds":"2-hydroxybiphenyl + H(+) + NADH + O2 = biphenyl-2,3-diol + H2O + NAD(+)"}
{"X":15344,"RHEA_ID":11997,"DIRECTION":"LR","MASTER_ID":11996,"metacyc":"2-HYDROXYBIPHENYL-3-MONOOXYGENASE-RXN","compounds":"2-hydroxybiphenyl + H(+) + NADH + O2 => biphenyl-2,3-diol + H2O + NAD(+)"}
{"X":15345,"RHEA_ID":11998,"compounds":"biphenyl-2,3-diol + H2O + NAD(+) => 2-hydroxybiphenyl + H(+) + NADH + O2"}
{"X":15346,"RHEA_ID":21832,"DIRECTION":"UN","MASTER_ID":21832,"ec":"2.1.1.83","compounds":"3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine = 3',5-dihydroxy-3,4',7-trimethoxyflavone + H(+) + S-adenosyl-L-homocysteine"}
{"X":15347,"RHEA_ID":12000,"DIRECTION":"UN","MASTER_ID":12000,"ec":"1.17.1.10","compounds":"formate + NADP(+) = CO2 + NADPH"}
{"X":15348,"RHEA_ID":12001,"compounds":"formate + NADP(+) => CO2 + NADPH"}
{"X":15349,"RHEA_ID":12002,"compounds":"CO2 + NADPH => formate + NADP(+)"}
{"X":15350,"RHEA_ID":12004,"DIRECTION":"UN","MASTER_ID":12004,"ec":"2.4.1.220","compounds":"indoxyl + UDP-alpha-D-glucose = H(+) + indican + UDP"}
{"X":15351,"RHEA_ID":12005,"DIRECTION":"LR","MASTER_ID":12004,"metacyc":"2.4.1.220-RXN","compounds":"indoxyl + UDP-alpha-D-glucose => H(+) + indican + UDP"}
{"X":15352,"RHEA_ID":12006,"compounds":"H(+) + indican + UDP => indoxyl + UDP-alpha-D-glucose"}
{"X":15353,"RHEA_ID":21840,"compounds":"N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine"}
{"X":15354,"RHEA_ID":12008,"DIRECTION":"UN","MASTER_ID":12008,"ec":"2.7.11.16","compounds":"[G-protein-coupled receptor] + ATP = [G-protein-coupled receptor]-phosphate + ADP + H(+)"}
{"X":15355,"RHEA_ID":12009,"compounds":"[G-protein-coupled receptor] + ATP => [G-protein-coupled receptor]-phosphate + ADP + H(+)"}
{"X":15356,"RHEA_ID":12010,"compounds":"[G-protein-coupled receptor]-phosphate + ADP + H(+) => [G-protein-coupled receptor] + ATP"}
{"X":15357,"RHEA_ID":12011,"DIRECTION":"BI","MASTER_ID":12008,"metacyc":"2.7.11.16-RXN","compounds":"[G-protein-coupled receptor] + ATP <=> [G-protein-coupled receptor]-phosphate + ADP + H(+)"}
{"X":15358,"RHEA_ID":12012,"DIRECTION":"UN","MASTER_ID":12012,"ec":"2.7.1.89","compounds":"ATP + thiamine = ADP + H(+) + thiamine phosphate"}
{"X":15359,"RHEA_ID":12013,"DIRECTION":"LR","MASTER_ID":12012,"ecocyc":"THIKIN-RXN","metacyc":"THIKIN-RXN","compounds":"ATP + thiamine => ADP + H(+) + thiamine phosphate"}
{"X":15360,"RHEA_ID":12014,"compounds":"ADP + H(+) + thiamine phosphate => ATP + thiamine"}
{"X":15361,"RHEA_ID":21848,"DIRECTION":"UN","MASTER_ID":21848,"ec":"5.2.1.6","metacyc":"FURYLFURAMIDE-ISOMERASE-RXN","compounds":"(E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide = (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide"}
{"X":15362,"RHEA_ID":12016,"DIRECTION":"UN","MASTER_ID":12016,"ec":"4.2.3.75","compounds":"(2E,6E)-farnesyl diphosphate = (-)-germacrene D + diphosphate"}
{"X":15363,"RHEA_ID":12017,"DIRECTION":"LR","MASTER_ID":12016,"metacyc":"RXN-8562","compounds":"(2E,6E)-farnesyl diphosphate => (-)-germacrene D + diphosphate"}
{"X":15364,"RHEA_ID":12018,"compounds":"(-)-germacrene D + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":15365,"RHEA_ID":21852,"DIRECTION":"UN","MASTER_ID":21852,"ec":"4.2.1.53","compounds":"(R)-10-hydroxyoctadecanoate = (9Z)-octadecenoate + H2O"}
{"X":15366,"RHEA_ID":12020,"DIRECTION":"UN","MASTER_ID":12020,"ec":"3.5.1.4","compounds":"a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)"}
{"X":15367,"RHEA_ID":12021,"compounds":"a monocarboxylic acid amide + H2O => a monocarboxylate + NH4(+)"}
{"X":15368,"RHEA_ID":12022,"compounds":"a monocarboxylate + NH4(+) => a monocarboxylic acid amide + H2O"}
{"X":15369,"RHEA_ID":12024,"DIRECTION":"UN","MASTER_ID":12024,"ec":"2.3.1.91","compounds":"1-O-(trans-sinapoyl)-beta-D-glucose + choline = D-glucose + O-sinapoylcholine"}
{"X":15370,"RHEA_ID":12025,"DIRECTION":"LR","MASTER_ID":12024,"metacyc":"2.3.1.91-RXN","compounds":"1-O-(trans-sinapoyl)-beta-D-glucose + choline => D-glucose + O-sinapoylcholine"}
{"X":15371,"RHEA_ID":12026,"compounds":"D-glucose + O-sinapoylcholine => 1-O-(trans-sinapoyl)-beta-D-glucose + choline"}
{"X":15372,"RHEA_ID":21860,"DIRECTION":"UN","MASTER_ID":21860,"ec":"2.8.2.28","compounds":"3'-phosphoadenylyl sulfate + quercetin 3,3'-bissulfate = adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3',7-trissulfate"}
{"X":15373,"RHEA_ID":12028,"DIRECTION":"UN","MASTER_ID":12028,"ec":"3.5.2.4","metacyc":"CARBOXYMETHYLHYDANTOINASE-RXN","compounds":"H2O + L-5-carboxymethylhydantoin = H(+) + N-carbamoyl-L-aspartate"}
{"X":15374,"RHEA_ID":12029,"compounds":"H2O + L-5-carboxymethylhydantoin => H(+) + N-carbamoyl-L-aspartate"}
{"X":15375,"RHEA_ID":12030,"compounds":"H(+) + N-carbamoyl-L-aspartate => H2O + L-5-carboxymethylhydantoin"}
{"X":15376,"RHEA_ID":21864,"DIRECTION":"UN","MASTER_ID":21864,"ec":"3.1.2.6","compounds":"an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)"}
{"X":15377,"RHEA_ID":12032,"DIRECTION":"UN","MASTER_ID":12032,"ec":"3.1.1.77","compounds":"a 3-(acyloxy)acyl derivative of bacterial toxin + H2O = 3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+)"}
{"X":15378,"RHEA_ID":12033,"DIRECTION":"LR","MASTER_ID":12032,"metacyc":"3.1.1.77-RXN","compounds":"a 3-(acyloxy)acyl derivative of bacterial toxin + H2O => 3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+)"}
{"X":15379,"RHEA_ID":12034,"compounds":"3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+) => a 3-(acyloxy)acyl derivative of bacterial toxin + H2O"}
{"X":15380,"RHEA_ID":12035,"compounds":"a 3-(acyloxy)acyl derivative of bacterial toxin + H2O <=> 3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+)"}
{"X":15381,"RHEA_ID":12036,"DIRECTION":"UN","MASTER_ID":12036,"ec":"1.1.1.111","compounds":"(S)-3-(imidazol-5-yl)lactate + NAD(+) = 3-(imidazol-5-yl)pyruvate + H(+) + NADH"}
{"X":15382,"RHEA_ID":12037,"compounds":"(S)-3-(imidazol-5-yl)lactate + NAD(+) => 3-(imidazol-5-yl)pyruvate + H(+) + NADH"}
{"X":15383,"RHEA_ID":12038,"compounds":"3-(imidazol-5-yl)pyruvate + H(+) + NADH => (S)-3-(imidazol-5-yl)lactate + NAD(+)"}
{"X":15384,"RHEA_ID":21872,"compounds":"L-arginyl-[cytochrome c] + S-adenosyl-L-methionine = H(+) + N(omega)-methyl-L-arginyl-[cytochrome c] + S-adenosyl-L-homocysteine"}
{"X":15385,"RHEA_ID":12040,"DIRECTION":"UN","MASTER_ID":12040,"ec":"1.1.1.111","compounds":"(S)-3-(imidazol-5-yl)lactate + NADP(+) = 3-(imidazol-5-yl)pyruvate + H(+) + NADPH"}
{"X":15386,"RHEA_ID":12041,"compounds":"(S)-3-(imidazol-5-yl)lactate + NADP(+) => 3-(imidazol-5-yl)pyruvate + H(+) + NADPH"}
{"X":15387,"RHEA_ID":12042,"compounds":"3-(imidazol-5-yl)pyruvate + H(+) + NADPH => (S)-3-(imidazol-5-yl)lactate + NADP(+)"}
{"X":15388,"RHEA_ID":21876,"DIRECTION":"UN","MASTER_ID":21876,"ec":"1.1.1.199","metacyc":"1.1.1.199-RXN","compounds":"(6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD(+) = (S)-usnate + 2 H(+) + NADH"}
{"X":15389,"RHEA_ID":12044,"DIRECTION":"UN","MASTER_ID":12044,"ec":"3.1.1.79","compounds":"a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)"}
{"X":15390,"RHEA_ID":12044,"DIRECTION":"UN","MASTER_ID":12044,"ec":"3.1.1.3","compounds":"a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)"}
{"X":15391,"RHEA_ID":12044,"DIRECTION":"UN","MASTER_ID":12044,"ec":"3.1.1.34","compounds":"a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)"}
{"X":15392,"RHEA_ID":12045,"DIRECTION":"LR","MASTER_ID":12044,"metacyc":"RXN-19278","compounds":"a triacylglycerol + H2O => a diacylglycerol + a fatty acid + H(+)"}
{"X":15393,"RHEA_ID":12046,"compounds":"a diacylglycerol + a fatty acid + H(+) => a triacylglycerol + H2O"}
{"X":15394,"RHEA_ID":12048,"DIRECTION":"UN","MASTER_ID":12048,"ec":"2.8.3.6","compounds":"3-oxoadipate + succinyl-CoA = 3-oxoadipyl-CoA + succinate"}
{"X":15395,"RHEA_ID":12049,"DIRECTION":"LR","MASTER_ID":12048,"metacyc":"3-OXOADIPATE-COA-TRANSFERASE-RXN","compounds":"3-oxoadipate + succinyl-CoA => 3-oxoadipyl-CoA + succinate"}
{"X":15396,"RHEA_ID":12050,"compounds":"3-oxoadipyl-CoA + succinate => 3-oxoadipate + succinyl-CoA"}
{"X":15397,"RHEA_ID":21886,"compounds":"H(+) + sulfate + thiosulfate => H2O + trithionate"}
{"X":15398,"RHEA_ID":12052,"DIRECTION":"UN","MASTER_ID":12052,"ec":"4.2.3.6","compounds":"(2E,6E)-farnesyl diphosphate = diphosphate + trichodiene"}
{"X":15399,"RHEA_ID":12053,"DIRECTION":"LR","MASTER_ID":12052,"macie":"M0262","metacyc":"TRICHODIENE-SYNTHASE-RXN","compounds":"(2E,6E)-farnesyl diphosphate => diphosphate + trichodiene"}
{"X":15400,"RHEA_ID":12054,"compounds":"diphosphate + trichodiene => (2E,6E)-farnesyl diphosphate"}
{"X":15401,"RHEA_ID":21890,"DIRECTION":"RL","MASTER_ID":21888,"metacyc":"12-OXOPHYTODIENOATE-REDUCTASE-RXN","compounds":"(10Z,15Z)-12-oxophytodienoate + H(+) + NADPH => NADP(+) + OPC-8"}
{"X":15402,"RHEA_ID":12056,"DIRECTION":"UN","MASTER_ID":12056,"ec":"1.2.1.72","compounds":"D-erythrose 4-phosphate + H2O + NAD(+) = 4-phospho-D-erythronate + 2 H(+) + NADH"}
{"X":15403,"RHEA_ID":12057,"DIRECTION":"LR","MASTER_ID":12056,"ecocyc":"ERYTH4PDEHYDROG-RXN","metacyc":"ERYTH4PDEHYDROG-RXN","compounds":"D-erythrose 4-phosphate + H2O + NAD(+) => 4-phospho-D-erythronate + 2 H(+) + NADH"}
{"X":15404,"RHEA_ID":12058,"compounds":"4-phospho-D-erythronate + 2 H(+) + NADH => D-erythrose 4-phosphate + H2O + NAD(+)"}
{"X":15405,"RHEA_ID":21893,"DIRECTION":"LR","MASTER_ID":21892,"metacyc":"RXN-8776","compounds":"D-arabinose + NADP(+) => D-arabinono-1,4-lactone + H(+) + NADPH"}
{"X":15406,"RHEA_ID":12064,"DIRECTION":"UN","MASTER_ID":12064,"ec":"1.2.1.20","compounds":"5-oxopentanoate + H2O + NAD(+) = glutarate + 2 H(+) + NADH"}
{"X":15407,"RHEA_ID":12065,"DIRECTION":"LR","MASTER_ID":12064,"metacyc":"GLUTARATE-SEMIALDEHYDE-DEHYDROGENASE-RXN","compounds":"5-oxopentanoate + H2O + NAD(+) => glutarate + 2 H(+) + NADH"}
{"X":15408,"RHEA_ID":12066,"compounds":"glutarate + 2 H(+) + NADH => 5-oxopentanoate + H2O + NAD(+)"}
{"X":15409,"RHEA_ID":21897,"DIRECTION":"LR","MASTER_ID":21896,"metacyc":"RXN-6261","compounds":"(R)-1-aminopropan-2-yl phosphate + adenosylcob(III)yrate + ATP => adenosylcob(III)inamide phosphate + ADP + H(+) + phosphate"}
{"X":15410,"RHEA_ID":12068,"DIRECTION":"UN","MASTER_ID":12068,"ec":"2.7.8.7","compounds":"apo-[ACP] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[ACP]"}
{"X":15411,"RHEA_ID":12069,"DIRECTION":"LR","MASTER_ID":12068,"ecocyc":"HOLO-ACP-SYNTH-RXN","metacyc":"HOLO-ACP-SYNTH-RXN","compounds":"apo-[ACP] + CoA => adenosine 3',5'-bisphosphate + H(+) + holo-[ACP]"}
{"X":15412,"RHEA_ID":12070,"compounds":"adenosine 3',5'-bisphosphate + H(+) + holo-[ACP] => apo-[ACP] + CoA"}
{"X":15413,"RHEA_ID":21905,"DIRECTION":"LR","MASTER_ID":21904,"metacyc":"BISPHOSPHOGLYCERATE-PHOSPHATASE-RXN","compounds":"(2R)-2,3-bisphosphoglycerate + H2O => (2R)-3-phosphoglycerate + phosphate"}
{"X":15414,"RHEA_ID":12072,"DIRECTION":"UN","MASTER_ID":12072,"ec":"3.8.1.11","compounds":"an (S)-2-haloacid + H2O = a (2S)-2-hydroxycarboxylate + a halide anion + H(+)"}
{"X":15415,"RHEA_ID":12073,"DIRECTION":"LR","MASTER_ID":12072,"metacyc":"3.8.1.11-RXN","compounds":"an (S)-2-haloacid + H2O => a (2S)-2-hydroxycarboxylate + a halide anion + H(+)"}
{"X":15416,"RHEA_ID":12074,"compounds":"a (2S)-2-hydroxycarboxylate + a halide anion + H(+) => an (S)-2-haloacid + H2O"}
{"X":15417,"RHEA_ID":12076,"DIRECTION":"UN","MASTER_ID":12076,"ec":"1.1.1.90","compounds":"an aromatic primary alcohol + NAD(+) = an aromatic aldehyde + H(+) + NADH"}
{"X":15418,"RHEA_ID":12077,"DIRECTION":"LR","MASTER_ID":12076,"metacyc":"ARYL-ALCOHOL-DEHYDROGENASE-RXN","compounds":"an aromatic primary alcohol + NAD(+) => an aromatic aldehyde + H(+) + NADH"}
{"X":15419,"RHEA_ID":12078,"compounds":"an aromatic aldehyde + H(+) + NADH => an aromatic primary alcohol + NAD(+)"}
{"X":15420,"RHEA_ID":21913,"DIRECTION":"LR","MASTER_ID":21912,"metacyc":"PYRUVATE-OXIDASE-COA-ACETYLATING-RXN","compounds":"CoA + H(+) + O2 + pyruvate => acetyl-CoA + CO2 + H2O2"}
{"X":15421,"RHEA_ID":12080,"DIRECTION":"UN","MASTER_ID":12080,"ec":"2.3.1.180","compounds":"acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA"}
{"X":15422,"RHEA_ID":12081,"DIRECTION":"LR","MASTER_ID":12080,"ecocyc":"2.3.1.180-RXN","metacyc":"2.3.1.180-RXN","compounds":"acetyl-CoA + H(+) + malonyl-[ACP] => 3-oxobutanoyl-[ACP] + CO2 + CoA"}
{"X":15423,"RHEA_ID":12082,"compounds":"3-oxobutanoyl-[ACP] + CO2 + CoA => acetyl-CoA + H(+) + malonyl-[ACP]"}
{"X":15424,"RHEA_ID":21917,"compounds":"2 [Fe(III)cytochrome c550] + an aliphatic amine + H2O => 2 [Fe(II)cytochrome c550] + an aldehyde + 2 H(+) + NH4(+)"}
{"X":15425,"RHEA_ID":12084,"DIRECTION":"UN","MASTER_ID":12084,"ec":"1.1.1.67","compounds":"D-mannitol + NAD(+) = D-fructose + H(+) + NADH"}
{"X":15426,"RHEA_ID":12085,"compounds":"D-mannitol + NAD(+) => D-fructose + H(+) + NADH"}
{"X":15427,"RHEA_ID":12086,"compounds":"D-fructose + H(+) + NADH => D-mannitol + NAD(+)"}
{"X":15428,"RHEA_ID":21921,"compounds":"di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine => Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + UMP"}
{"X":15429,"RHEA_ID":12088,"DIRECTION":"UN","MASTER_ID":12088,"ec":"2.4.1.80","compounds":"an N-acylsphing-4-enine + UDP-alpha-D-glucose = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP"}
{"X":15430,"RHEA_ID":12089,"compounds":"an N-acylsphing-4-enine + UDP-alpha-D-glucose => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP"}
{"X":15431,"RHEA_ID":12090,"compounds":"a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP => an N-acylsphing-4-enine + UDP-alpha-D-glucose"}
{"X":15432,"RHEA_ID":21925,"compounds":"3-dehydro-L-gulonate + NAD(+) => 2,3-dioxo-L-gulonate + H(+) + NADH"}
{"X":15433,"RHEA_ID":12092,"DIRECTION":"UN","MASTER_ID":12092,"ec":"5.1.2.4","metacyc":"ACETOIN-RACEMASE-RXN","compounds":"(S)-acetoin = (R)-acetoin"}
{"X":15434,"RHEA_ID":12093,"compounds":"(S)-acetoin => (R)-acetoin"}
{"X":15435,"RHEA_ID":12094,"compounds":"(R)-acetoin => (S)-acetoin"}
{"X":15436,"RHEA_ID":12096,"DIRECTION":"UN","MASTER_ID":12096,"ec":"3.5.1.91","compounds":"H2O + N-benzylformamide = benzylamine + formate"}
{"X":15437,"RHEA_ID":12097,"compounds":"H2O + N-benzylformamide => benzylamine + formate"}
{"X":15438,"RHEA_ID":12098,"compounds":"benzylamine + formate => H2O + N-benzylformamide"}
{"X":15439,"RHEA_ID":21933,"DIRECTION":"LR","MASTER_ID":21932,"metacyc":"ADENOSYLMETHIONINE-CYCLOTRANSFERASE-RXN","compounds":"S-adenosyl-L-methionine => homoserine lactone + S-methyl-5'-thioadenosine"}
{"X":15440,"RHEA_ID":12100,"DIRECTION":"UN","MASTER_ID":12100,"ec":"4.2.1.110","compounds":"1,5-anhydro-D-fructose = H2O + microthecin"}
{"X":15441,"RHEA_ID":12101,"compounds":"1,5-anhydro-D-fructose => H2O + microthecin"}
{"X":15442,"RHEA_ID":12102,"compounds":"H2O + microthecin => 1,5-anhydro-D-fructose"}
{"X":15443,"RHEA_ID":21937,"compounds":"carbamoyl phosphate + putrescine => H(+) + N-carbamoylputrescine + phosphate"}
{"X":15444,"RHEA_ID":12104,"DIRECTION":"UN","MASTER_ID":12104,"ec":"2.1.1.45","compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8-dihydrofolate + dTMP"}
{"X":15445,"RHEA_ID":12105,"DIRECTION":"LR","MASTER_ID":12104,"ecocyc":"THYMIDYLATESYN-RXN","macie":"M0031","metacyc":"THYMIDYLATESYN-RXN","compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP => 7,8-dihydrofolate + dTMP"}
{"X":15446,"RHEA_ID":12106,"compounds":"7,8-dihydrofolate + dTMP => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP"}
{"X":15447,"RHEA_ID":21941,"DIRECTION":"LR","MASTER_ID":21940,"metacyc":"SQUALENE-MONOOXYGENASE-RXN","compounds":"AH2 + O2 + squalene => (S)-2,3-epoxysqualene + A + H2O"}
{"X":15448,"RHEA_ID":12108,"compounds":"L-arginyl-[histone] + S-adenosyl-L-methionine = H(+) + N(omega)-methyl-L-arginyl-[histone] + S-adenosyl-L-homocysteine"}
{"X":15449,"RHEA_ID":12109,"DIRECTION":"LR","MASTER_ID":12108,"metacyc":"2.1.1.125-RXN","compounds":"L-arginyl-[histone] + S-adenosyl-L-methionine => H(+) + N(omega)-methyl-L-arginyl-[histone] + S-adenosyl-L-homocysteine"}
{"X":15450,"RHEA_ID":12110,"compounds":"H(+) + N(omega)-methyl-L-arginyl-[histone] + S-adenosyl-L-homocysteine => L-arginyl-[histone] + S-adenosyl-L-methionine"}
{"X":15451,"RHEA_ID":21945,"compounds":"ATP + D-cellobiose => 6-phospho-beta-D-glucosyl-(1->4)-D-glucose + ADP + H(+)"}
{"X":15452,"RHEA_ID":12112,"DIRECTION":"UN","MASTER_ID":12112,"ec":"2.1.1.47","compounds":"indole-3-pyruvate + S-adenosyl-L-methionine = (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + S-adenosyl-L-homocysteine"}
{"X":15453,"RHEA_ID":12113,"DIRECTION":"LR","MASTER_ID":12112,"metacyc":"INDOLEPYRUVATE-C-METHYLTRANSFERASE-RXN","compounds":"indole-3-pyruvate + S-adenosyl-L-methionine => (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + S-adenosyl-L-homocysteine"}
{"X":15454,"RHEA_ID":12114,"compounds":"(R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + S-adenosyl-L-homocysteine => indole-3-pyruvate + S-adenosyl-L-methionine"}
{"X":15455,"RHEA_ID":21949,"compounds":"formamide + H2O => formate + NH4(+)"}
{"X":15456,"RHEA_ID":12116,"DIRECTION":"UN","MASTER_ID":12116,"ec":"1.12.99.6","compounds":"A + H2 = AH2"}
{"X":15457,"RHEA_ID":12117,"compounds":"A + H2 => AH2"}
{"X":15458,"RHEA_ID":12118,"compounds":"AH2 => A + H2"}
{"X":15459,"RHEA_ID":12120,"DIRECTION":"UN","MASTER_ID":12120,"ec":"2.7.7.27","compounds":"alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate"}
{"X":15460,"RHEA_ID":12121,"DIRECTION":"LR","MASTER_ID":12120,"ecocyc":"GLUC1PADENYLTRANS-RXN","metacyc":"GLUC1PADENYLTRANS-RXN","compounds":"alpha-D-glucose 1-phosphate + ATP + H(+) => ADP-alpha-D-glucose + diphosphate"}
{"X":15461,"RHEA_ID":12122,"compounds":"ADP-alpha-D-glucose + diphosphate => alpha-D-glucose 1-phosphate + ATP + H(+)"}
{"X":15462,"RHEA_ID":21957,"DIRECTION":"LR","MASTER_ID":21956,"metacyc":"VITEXIN-BETA-GLUCOSYLTRANSFERASE-RXN","compounds":"UDP-alpha-D-glucose + vitexin => H(+) + UDP + vitexin 2''-O-beta-D-glucoside"}
{"X":15463,"RHEA_ID":12124,"DIRECTION":"UN","MASTER_ID":12124,"ec":"2.3.1.133","compounds":"4-coumaroyl-CoA + shikimate = CoA + trans-4-coumaroylshikimate"}
{"X":15464,"RHEA_ID":12125,"DIRECTION":"LR","MASTER_ID":12124,"metacyc":"2.3.1.133-RXN","compounds":"4-coumaroyl-CoA + shikimate => CoA + trans-4-coumaroylshikimate"}
{"X":15465,"RHEA_ID":12126,"compounds":"CoA + trans-4-coumaroylshikimate => 4-coumaroyl-CoA + shikimate"}
{"X":15466,"RHEA_ID":21961,"compounds":"(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + [protein]-disulfide + H(+) + H2O => 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + [protein]-dithiol"}
{"X":15467,"RHEA_ID":12128,"DIRECTION":"UN","MASTER_ID":12128,"ec":"1.4.7.1","compounds":"2 L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin] = 2-oxoglutarate + 2 H(+) + L-glutamine + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":15468,"RHEA_ID":12129,"compounds":"2 L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-oxoglutarate + 2 H(+) + L-glutamine + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":15469,"RHEA_ID":12130,"DIRECTION":"RL","MASTER_ID":12128,"metacyc":"GLUTAMATE-SYNTHASE-FERREDOXIN-RXN","compounds":"2-oxoglutarate + 2 H(+) + L-glutamine + 2 reduced [2Fe-2S]-[ferredoxin] => 2 L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":15470,"RHEA_ID":21965,"DIRECTION":"LR","MASTER_ID":21964,"metacyc":"CHOLINESTERASE-RXN","compounds":"an acylcholine + H2O => a carboxylate + choline + H(+)"}
{"X":15471,"RHEA_ID":12132,"DIRECTION":"UN","MASTER_ID":12132,"ec":"7.2.2.2","compounds":"ATP + Cd(2+)(in) + H2O = ADP + Cd(2+)(out) + H(+) + phosphate"}
{"X":15472,"RHEA_ID":12132,"DIRECTION":"UN","MASTER_ID":12132,"ec":"7.2.2.21","compounds":"ATP + Cd(2+)(in) + H2O = ADP + Cd(2+)(out) + H(+) + phosphate"}
{"X":15473,"RHEA_ID":12133,"DIRECTION":"LR","MASTER_ID":12132,"ecocyc":"3.6.3.3-RXN","metacyc":"3.6.3.46-RXN","compounds":"ATP + Cd(2+)(in) + H2O => ADP + Cd(2+)(out) + H(+) + phosphate"}
{"X":15474,"RHEA_ID":12133,"DIRECTION":"LR","MASTER_ID":12132,"ecocyc":"3.6.3.3-RXN","metacyc":"3.6.3.3-RXN","compounds":"ATP + Cd(2+)(in) + H2O => ADP + Cd(2+)(out) + H(+) + phosphate"}
{"X":15475,"RHEA_ID":12134,"compounds":"ADP + Cd(2+)(out) + H(+) + phosphate => ATP + Cd(2+)(in) + H2O"}
{"X":15476,"RHEA_ID":12135,"compounds":"ATP + Cd(2+)(in) + H2O <=> ADP + Cd(2+)(out) + H(+) + phosphate"}
{"X":15477,"RHEA_ID":12136,"DIRECTION":"UN","MASTER_ID":12136,"ec":"1.3.1.34","compounds":"a 4,5-saturated-(2E)-enoyl-CoA + NADP(+) = a (2E,4E)-dienoyl-CoA + H(+) + NADPH"}
{"X":15478,"RHEA_ID":12137,"compounds":"a 4,5-saturated-(2E)-enoyl-CoA + NADP(+) => a (2E,4E)-dienoyl-CoA + H(+) + NADPH"}
{"X":15479,"RHEA_ID":12138,"DIRECTION":"RL","MASTER_ID":12136,"metacyc":"RXN-7911","compounds":"a (2E,4E)-dienoyl-CoA + H(+) + NADPH => a 4,5-saturated-(2E)-enoyl-CoA + NADP(+)"}
{"X":15480,"RHEA_ID":12140,"DIRECTION":"UN","MASTER_ID":12140,"ec":"2.7.1.145","compounds":"a 2'-deoxyribonucleoside + ATP = a 2'-deoxyribonucleoside 5'-phosphate + ADP + H(+)"}
{"X":15481,"RHEA_ID":12141,"DIRECTION":"LR","MASTER_ID":12140,"metacyc":"2.7.1.145-RXN","compounds":"a 2'-deoxyribonucleoside + ATP => a 2'-deoxyribonucleoside 5'-phosphate + ADP + H(+)"}
{"X":15482,"RHEA_ID":12142,"compounds":"a 2'-deoxyribonucleoside 5'-phosphate + ADP + H(+) => a 2'-deoxyribonucleoside + ATP"}
{"X":15483,"RHEA_ID":42524,"DIRECTION":"UN","MASTER_ID":42524,"ec":"5.4.99.23","compounds":"uridine(1911/1915/1917) in 23S rRNA = pseudouridine(1911/1915/1917) in 23S rRNA"}
{"X":15484,"RHEA_ID":12144,"DIRECTION":"UN","MASTER_ID":12144,"ec":"2.4.1.116","compounds":"cyanidin 3-O-rutinoside + UDP-alpha-D-glucose = cyanidin 3-O-rutinoside 5-O-beta-D-glucoside + H(+) + UDP"}
{"X":15485,"RHEA_ID":12145,"compounds":"cyanidin 3-O-rutinoside + UDP-alpha-D-glucose => cyanidin 3-O-rutinoside 5-O-beta-D-glucoside + H(+) + UDP"}
{"X":15486,"RHEA_ID":12146,"compounds":"cyanidin 3-O-rutinoside 5-O-beta-D-glucoside + H(+) + UDP => cyanidin 3-O-rutinoside + UDP-alpha-D-glucose"}
{"X":15487,"RHEA_ID":21983,"compounds":"3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) <=> adenosine 3',5'-bisphosphate + 2 H(+) + N-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n)"}
{"X":15488,"RHEA_ID":12152,"compounds":"(3R,4S,5S,6R)-pentachlorocyclohexene = (3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + chloride + H(+)"}
{"X":15489,"RHEA_ID":12153,"DIRECTION":"LR","MASTER_ID":12152,"metacyc":"LINA2-RXN","compounds":"(3R,4S,5S,6R)-pentachlorocyclohexene => (3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + chloride + H(+)"}
{"X":15490,"RHEA_ID":12154,"compounds":"(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + chloride + H(+) => (3R,4S,5S,6R)-pentachlorocyclohexene"}
{"X":15491,"RHEA_ID":42532,"DIRECTION":"UN","MASTER_ID":42532,"ec":"5.4.99.25","compounds":"uridine(55) in tRNA = pseudouridine(55) in tRNA"}
{"X":15492,"RHEA_ID":12156,"DIRECTION":"UN","MASTER_ID":12156,"ec":"1.1.1.398","compounds":"2-glutathionyl-2-methylbut-3-en-1-ol + H2O + 2 NAD(+) = 2-glutathionyl-2-methylbut-3-enoate + 3 H(+) + 2 NADH"}
{"X":15493,"RHEA_ID":12157,"compounds":"2-glutathionyl-2-methylbut-3-en-1-ol + H2O + 2 NAD(+) => 2-glutathionyl-2-methylbut-3-enoate + 3 H(+) + 2 NADH"}
{"X":15494,"RHEA_ID":12158,"compounds":"2-glutathionyl-2-methylbut-3-enoate + 3 H(+) + 2 NADH => 2-glutathionyl-2-methylbut-3-en-1-ol + H2O + 2 NAD(+)"}
{"X":15495,"RHEA_ID":12159,"DIRECTION":"BI","MASTER_ID":12156,"metacyc":"RXN-17599","compounds":"2-glutathionyl-2-methylbut-3-en-1-ol + H2O + 2 NAD(+) <=> 2-glutathionyl-2-methylbut-3-enoate + 3 H(+) + 2 NADH"}
{"X":15496,"RHEA_ID":12160,"DIRECTION":"UN","MASTER_ID":12160,"ec":"1.1.1.125","compounds":"2-deoxy-D-gluconate + NAD(+) = 3-dehydro-2-deoxy-D-gluconate + H(+) + NADH"}
{"X":15497,"RHEA_ID":12161,"DIRECTION":"LR","MASTER_ID":12160,"ecocyc":"KDUD-RXN","metacyc":"KDUD-RXN","compounds":"2-deoxy-D-gluconate + NAD(+) => 3-dehydro-2-deoxy-D-gluconate + H(+) + NADH"}
{"X":15498,"RHEA_ID":12162,"compounds":"3-dehydro-2-deoxy-D-gluconate + H(+) + NADH => 2-deoxy-D-gluconate + NAD(+)"}
{"X":15499,"RHEA_ID":42540,"DIRECTION":"UN","MASTER_ID":42540,"ec":"5.4.99.27","compounds":"uridine(13) in tRNA = pseudouridine(13) in tRNA"}
{"X":15500,"RHEA_ID":12164,"DIRECTION":"UN","MASTER_ID":12164,"ec":"2.8.2.1","compounds":"3'-phosphoadenylyl sulfate + a phenol = a phenyl sulfate + adenosine 3',5'-bisphosphate + H(+)"}
{"X":15501,"RHEA_ID":12165,"DIRECTION":"LR","MASTER_ID":12164,"metacyc":"ARYL-SULFOTRANSFERASE-RXN","compounds":"3'-phosphoadenylyl sulfate + a phenol => a phenyl sulfate + adenosine 3',5'-bisphosphate + H(+)"}
{"X":15502,"RHEA_ID":12166,"compounds":"a phenyl sulfate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + a phenol"}
{"X":15503,"RHEA_ID":12168,"DIRECTION":"UN","MASTER_ID":12168,"ec":"1.1.1.54","compounds":"allyl alcohol + NADP(+) = acrolein + H(+) + NADPH"}
{"X":15504,"RHEA_ID":12169,"compounds":"allyl alcohol + NADP(+) => acrolein + H(+) + NADPH"}
{"X":15505,"RHEA_ID":12170,"DIRECTION":"RL","MASTER_ID":12168,"metacyc":"ALLYL-ALCOHOL-DEHYDROGENASE-RXN","compounds":"acrolein + H(+) + NADPH => allyl alcohol + NADP(+)"}
{"X":15506,"RHEA_ID":12172,"DIRECTION":"UN","MASTER_ID":12172,"ec":"3.5.99.6","compounds":"alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)"}
{"X":15507,"RHEA_ID":12173,"compounds":"alpha-D-glucosamine 6-phosphate + H2O => beta-D-fructose 6-phosphate + NH4(+)"}
{"X":15508,"RHEA_ID":12174,"compounds":"beta-D-fructose 6-phosphate + NH4(+) => alpha-D-glucosamine 6-phosphate + H2O"}
{"X":15509,"RHEA_ID":22006,"compounds":"[myosin light chain]-O-phospho-L-serine + ADP + H(+) => [myosin light chain]-L-serine + ATP"}
{"X":15510,"RHEA_ID":12176,"DIRECTION":"UN","MASTER_ID":12176,"ec":"2.1.1.28","compounds":"phenylethanolamine + S-adenosyl-L-methionine = H(+) + N-methylphenylethanolamine + S-adenosyl-L-homocysteine"}
{"X":15511,"RHEA_ID":12177,"DIRECTION":"LR","MASTER_ID":12176,"metacyc":"2.1.1.28-RXN","compounds":"phenylethanolamine + S-adenosyl-L-methionine => H(+) + N-methylphenylethanolamine + S-adenosyl-L-homocysteine"}
{"X":15512,"RHEA_ID":12178,"compounds":"H(+) + N-methylphenylethanolamine + S-adenosyl-L-homocysteine => phenylethanolamine + S-adenosyl-L-methionine"}
{"X":15513,"RHEA_ID":22010,"compounds":"CoA + O-succinyl-L-homoserine => L-homoserine + succinyl-CoA"}
{"X":15514,"RHEA_ID":12180,"DIRECTION":"UN","MASTER_ID":12180,"ec":"2.1.1.111","compounds":"anthranilate + S-adenosyl-L-methionine = H(+) + N-methylanthranilate + S-adenosyl-L-homocysteine"}
{"X":15515,"RHEA_ID":12181,"DIRECTION":"LR","MASTER_ID":12180,"metacyc":"ANTHRANILATE-N-METHYLTRANSFERASE-RXN","compounds":"anthranilate + S-adenosyl-L-methionine => H(+) + N-methylanthranilate + S-adenosyl-L-homocysteine"}
{"X":15516,"RHEA_ID":12182,"compounds":"H(+) + N-methylanthranilate + S-adenosyl-L-homocysteine => anthranilate + S-adenosyl-L-methionine"}
{"X":15517,"RHEA_ID":22014,"compounds":"precorrin-5 + S-adenosyl-L-homocysteine => precorrin-4 + S-adenosyl-L-methionine"}
{"X":15518,"RHEA_ID":12184,"DIRECTION":"UN","MASTER_ID":12184,"ec":"1.1.1.76","compounds":"(S,S)-butane-2,3-diol + NAD(+) = (S)-acetoin + H(+) + NADH"}
{"X":15519,"RHEA_ID":12185,"compounds":"(S,S)-butane-2,3-diol + NAD(+) => (S)-acetoin + H(+) + NADH"}
{"X":15520,"RHEA_ID":12186,"compounds":"(S)-acetoin + H(+) + NADH => (S,S)-butane-2,3-diol + NAD(+)"}
{"X":15521,"RHEA_ID":12188,"DIRECTION":"UN","MASTER_ID":12188,"ec":"1.2.4.2","compounds":"2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase]-(R)-N(6)-lipoyl-L-lysine + H(+) = [dihydrolipoyllysine-residue succinyltransferase]-(R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysine + CO2"}
{"X":15522,"RHEA_ID":12189,"DIRECTION":"LR","MASTER_ID":12188,"ecocyc":"2OXOGLUTDECARB-RXN","metacyc":"2OXOGLUTDECARB-RXN","compounds":"2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase]-(R)-N(6)-lipoyl-L-lysine + H(+) => [dihydrolipoyllysine-residue succinyltransferase]-(R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysine + CO2"}
{"X":15523,"RHEA_ID":12190,"compounds":"[dihydrolipoyllysine-residue succinyltransferase]-(R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysine + CO2 => 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase]-(R)-N(6)-lipoyl-L-lysine + H(+)"}
{"X":15524,"RHEA_ID":12192,"DIRECTION":"UN","MASTER_ID":12192,"ec":"4.2.3.166","compounds":"(2E,6E)-farnesyl diphosphate + H2O = (+)-(1(10)E,4E,6S,7R)-germacradien-6-ol + diphosphate"}
{"X":15525,"RHEA_ID":12193,"DIRECTION":"LR","MASTER_ID":12192,"metacyc":"RXN-18793","compounds":"(2E,6E)-farnesyl diphosphate + H2O => (+)-(1(10)E,4E,6S,7R)-germacradien-6-ol + diphosphate"}
{"X":15526,"RHEA_ID":12194,"compounds":"(+)-(1(10)E,4E,6S,7R)-germacradien-6-ol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}
{"X":15527,"RHEA_ID":22026,"compounds":"2 H(+) + NADH + trimethylamine N-oxide => H2O + NAD(+) + trimethylamine"}
{"X":15528,"RHEA_ID":12196,"DIRECTION":"UN","MASTER_ID":12196,"ec":"4.1.2.22","compounds":"keto-D-fructose 6-phosphate + phosphate = acetyl phosphate + D-erythrose 4-phosphate + H2O"}
{"X":15529,"RHEA_ID":12197,"DIRECTION":"LR","MASTER_ID":12196,"metacyc":"FRUCTOSE-6-PHOSPHATE-PHOSPHOKETOLASE-RXN","compounds":"keto-D-fructose 6-phosphate + phosphate => acetyl phosphate + D-erythrose 4-phosphate + H2O"}
{"X":15530,"RHEA_ID":12198,"compounds":"acetyl phosphate + D-erythrose 4-phosphate + H2O => keto-D-fructose 6-phosphate + phosphate"}
{"X":15531,"RHEA_ID":22030,"compounds":"CoA + taxa-4(20),11-dien-5alpha-yl acetate => acetyl-CoA + taxa-4(20),11-dien-5alpha-ol"}
{"X":15532,"RHEA_ID":12200,"DIRECTION":"UN","MASTER_ID":12200,"ec":"1.14.11.24","compounds":"2'-deoxymugineate + 2-oxoglutarate + O2 = CO2 + mugineate + succinate"}
{"X":15533,"RHEA_ID":12201,"DIRECTION":"LR","MASTER_ID":12200,"metacyc":"1.14.11.24-RXN","compounds":"2'-deoxymugineate + 2-oxoglutarate + O2 => CO2 + mugineate + succinate"}
{"X":15534,"RHEA_ID":12202,"compounds":"CO2 + mugineate + succinate => 2'-deoxymugineate + 2-oxoglutarate + O2"}
{"X":15535,"RHEA_ID":22034,"compounds":"glyoxylate + oxaloacetate => 3-oxalomalate"}
{"X":15536,"RHEA_ID":12204,"compounds":"dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] = 3alpha-hydroxy-3,5-dihydromonacolin L carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":15537,"RHEA_ID":12205,"DIRECTION":"LR","MASTER_ID":12204,"metacyc":"RXN-15671","compounds":"dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] => 3alpha-hydroxy-3,5-dihydromonacolin L carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":15538,"RHEA_ID":12206,"compounds":"3alpha-hydroxy-3,5-dihydromonacolin L carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":15539,"RHEA_ID":22038,"compounds":"[phosphate](n-1) + D-glucose 6-phosphate + H(+) => [phosphate](n) + D-glucose"}
{"X":15540,"RHEA_ID":12208,"DIRECTION":"UN","MASTER_ID":12208,"ec":"3.1.1.56","compounds":"4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)"}
{"X":15541,"RHEA_ID":12209,"DIRECTION":"LR","MASTER_ID":12208,"metacyc":"3.1.1.56-RXN","compounds":"4-methylumbelliferyl acetate + H2O => 4-methylumbelliferone + acetate + H(+)"}
{"X":15542,"RHEA_ID":12210,"compounds":"4-methylumbelliferone + acetate + H(+) => 4-methylumbelliferyl acetate + H2O"}
{"X":15543,"RHEA_ID":22042,"compounds":"formate + L-aspartate => H2O + N-formyl-L-aspartate"}
{"X":15544,"RHEA_ID":12212,"DIRECTION":"UN","MASTER_ID":12212,"ec":"1.1.1.256","compounds":"9H-fluoren-9-ol + NADP(+) = 9H-fluoren-9-one + H(+) + NADPH"}
{"X":15545,"RHEA_ID":12213,"DIRECTION":"LR","MASTER_ID":12212,"metacyc":"9-FLUORENOL-DEHYDROGENASE-RXN","compounds":"9H-fluoren-9-ol + NADP(+) => 9H-fluoren-9-one + H(+) + NADPH"}
{"X":15546,"RHEA_ID":12214,"compounds":"9H-fluoren-9-one + H(+) + NADPH => 9H-fluoren-9-ol + NADP(+)"}
{"X":15547,"RHEA_ID":22046,"compounds":"ADP + 2 H(+)(out) + K(+)(in) + phosphate => ATP + H(+)(in) + H2O + K(+)(out)"}
{"X":15548,"RHEA_ID":12216,"DIRECTION":"UN","MASTER_ID":12216,"ec":"1.1.1.256","compounds":"9H-fluoren-9-ol + NAD(+) = 9H-fluoren-9-one + H(+) + NADH"}
{"X":15549,"RHEA_ID":12217,"DIRECTION":"LR","MASTER_ID":12216,"metacyc":"9-FLUORENOL-DEHYDROGENASE-RXN","compounds":"9H-fluoren-9-ol + NAD(+) => 9H-fluoren-9-one + H(+) + NADH"}
{"X":15550,"RHEA_ID":12218,"compounds":"9H-fluoren-9-one + H(+) + NADH => 9H-fluoren-9-ol + NAD(+)"}
{"X":15551,"RHEA_ID":22050,"compounds":"6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate => 7,8-dihydroneopterin 3'-triphosphate"}
{"X":15552,"RHEA_ID":12220,"DIRECTION":"UN","MASTER_ID":12220,"ec":"1.4.1.9","compounds":"H2O + L-leucine + NAD(+) = 4-methyl-2-oxopentanoate + H(+) + NADH + NH4(+)"}
{"X":15553,"RHEA_ID":12221,"compounds":"H2O + L-leucine + NAD(+) => 4-methyl-2-oxopentanoate + H(+) + NADH + NH4(+)"}
{"X":15554,"RHEA_ID":12222,"compounds":"4-methyl-2-oxopentanoate + H(+) + NADH + NH4(+) => H2O + L-leucine + NAD(+)"}
{"X":15555,"RHEA_ID":22054,"DIRECTION":"RL","MASTER_ID":22052,"ecocyc":"HYDROXYLAMINE-REDUCTASE-RXN","metacyc":"HYDROXYLAMINE-REDUCTASE-RXN","compounds":"AH2 + H(+) + hydroxylamine => A + H2O + NH4(+)"}
{"X":15556,"RHEA_ID":12228,"DIRECTION":"UN","MASTER_ID":12228,"ec":"6.3.5.4","compounds":"ATP + H2O + L-aspartate + L-glutamine = AMP + diphosphate + H(+) + L-asparagine + L-glutamate"}
{"X":15557,"RHEA_ID":12229,"DIRECTION":"LR","MASTER_ID":12228,"ecocyc":"ASNSYNB-RXN","macie":"M0302","metacyc":"ASNSYNB-RXN","reactome":"R-HSA-70599.3","compounds":"ATP + H2O + L-aspartate + L-glutamine => AMP + diphosphate + H(+) + L-asparagine + L-glutamate"}
{"X":15558,"RHEA_ID":12230,"compounds":"AMP + diphosphate + H(+) + L-asparagine + L-glutamate => ATP + H2O + L-aspartate + L-glutamine"}
{"X":15559,"RHEA_ID":22058,"compounds":"H(+) + hexadecanal + NADH => hexadecan-1-ol + NAD(+)"}
{"X":15560,"RHEA_ID":12232,"DIRECTION":"UN","MASTER_ID":12232,"ec":"1.21.4.2","compounds":"[thioredoxin]-disulfide + acetyl phosphate + H2O + NH4(+) = [thioredoxin]-dithiol + glycine + H(+) + phosphate"}
{"X":15561,"RHEA_ID":12233,"compounds":"[thioredoxin]-disulfide + acetyl phosphate + H2O + NH4(+) => [thioredoxin]-dithiol + glycine + H(+) + phosphate"}
{"X":15562,"RHEA_ID":12234,"DIRECTION":"RL","MASTER_ID":12232,"metacyc":"RXN-7566","compounds":"[thioredoxin]-dithiol + glycine + H(+) + phosphate => [thioredoxin]-disulfide + acetyl phosphate + H2O + NH4(+)"}
{"X":15563,"RHEA_ID":12236,"DIRECTION":"UN","MASTER_ID":12236,"ec":"1.17.1.5","compounds":"H2O + NADP(+) + nicotinate = 6-hydroxynicotinate + H(+) + NADPH"}
{"X":15564,"RHEA_ID":12237,"DIRECTION":"LR","MASTER_ID":12236,"metacyc":"RXN-7637","compounds":"H2O + NADP(+) + nicotinate => 6-hydroxynicotinate + H(+) + NADPH"}
{"X":15565,"RHEA_ID":12238,"compounds":"6-hydroxynicotinate + H(+) + NADPH => H2O + NADP(+) + nicotinate"}
{"X":15566,"RHEA_ID":22066,"compounds":"ergosterol + H2O => 5alpha-ergosta-7,22-diene-3beta,5-diol"}
{"X":15567,"RHEA_ID":12240,"DIRECTION":"UN","MASTER_ID":12240,"ec":"2.3.1.165","compounds":"acetyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH = 6-methylsalicylate + 3 CO2 + 4 CoA + H2O + NADP(+)"}
{"X":15568,"RHEA_ID":12241,"DIRECTION":"LR","MASTER_ID":12240,"metacyc":"2.3.1.165-RXN","compounds":"acetyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH => 6-methylsalicylate + 3 CO2 + 4 CoA + H2O + NADP(+)"}
{"X":15569,"RHEA_ID":12242,"compounds":"6-methylsalicylate + 3 CO2 + 4 CoA + H2O + NADP(+) => acetyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH"}
{"X":15570,"RHEA_ID":22069,"compounds":"(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) => (2S)-2-acetolactate + H(+) + NADPH"}
{"X":15571,"RHEA_ID":12244,"compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + FADH2 = (6S)-5,6,7,8-tetrahydrofolate + dTMP + FAD + H(+)"}
{"X":15572,"RHEA_ID":12245,"compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + FADH2 => (6S)-5,6,7,8-tetrahydrofolate + dTMP + FAD + H(+)"}
{"X":15573,"RHEA_ID":12246,"compounds":"(6S)-5,6,7,8-tetrahydrofolate + dTMP + FAD + H(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + FADH2"}
{"X":15574,"RHEA_ID":12247,"compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + FADH2 <=> (6S)-5,6,7,8-tetrahydrofolate + dTMP + FAD + H(+)"}
{"X":15575,"RHEA_ID":12248,"DIRECTION":"UN","MASTER_ID":12248,"ec":"1.3.1.98","compounds":"NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine"}
{"X":15576,"RHEA_ID":12249,"compounds":"NADP(+) + UDP-N-acetyl-alpha-D-muramate => H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine"}
{"X":15577,"RHEA_ID":12250,"DIRECTION":"RL","MASTER_ID":12248,"ecocyc":"UDPNACETYLMURAMATEDEHYDROG-RXN","metacyc":"UDPNACETYLMURAMATEDEHYDROG-RXN","compounds":"H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine => NADP(+) + UDP-N-acetyl-alpha-D-muramate"}
{"X":15578,"RHEA_ID":22080,"DIRECTION":"UN","MASTER_ID":22080,"ec":"1.14.13.61","compounds":"H(+) + NADH + O2 + quinolin-2-ol = H2O + NAD(+) + quinoline-2,8-diol"}
{"X":15579,"RHEA_ID":12252,"DIRECTION":"UN","MASTER_ID":12252,"ec":"3.2.1.126","compounds":"4-O-(beta-D-glucosyl)-trans-coniferol + H2O = (E)-coniferol + D-glucose"}
{"X":15580,"RHEA_ID":12253,"DIRECTION":"LR","MASTER_ID":12252,"metacyc":"CONIFERIN-BETA-GLUCOSIDASE-RXN","compounds":"4-O-(beta-D-glucosyl)-trans-coniferol + H2O => (E)-coniferol + D-glucose"}
{"X":15581,"RHEA_ID":12254,"compounds":"(E)-coniferol + D-glucose => 4-O-(beta-D-glucosyl)-trans-coniferol + H2O"}
{"X":15582,"RHEA_ID":22084,"DIRECTION":"UN","MASTER_ID":22084,"ec":"4.3.1.15","compounds":"(S)-2,3-diaminopropanoate + H(+) + H2O = 2 NH4(+) + pyruvate"}
{"X":15583,"RHEA_ID":12256,"DIRECTION":"UN","MASTER_ID":12256,"ec":"1.3.1.79","metacyc":"RXN-14476","compounds":"L-arogenate + NAD(+) = CO2 + L-tyrosine + NADH"}
{"X":15584,"RHEA_ID":12256,"DIRECTION":"UN","MASTER_ID":12256,"ec":"1.3.1.43","metacyc":"RXN-14476","compounds":"L-arogenate + NAD(+) = CO2 + L-tyrosine + NADH"}
{"X":15585,"RHEA_ID":12257,"DIRECTION":"LR","MASTER_ID":12256,"metacyc":"CYCLOHEXADIENYL-DEHYDROGENASE-RXN","compounds":"L-arogenate + NAD(+) => CO2 + L-tyrosine + NADH"}
{"X":15586,"RHEA_ID":12258,"compounds":"CO2 + L-tyrosine + NADH => L-arogenate + NAD(+)"}
{"X":15587,"RHEA_ID":22089,"DIRECTION":"LR","MASTER_ID":22088,"ecocyc":"GTPPYPHOSKIN-RXN","metacyc":"GTPPYPHOSKIN-RXN","compounds":"ATP + GTP => AMP + guanosine 3'-diphosphate 5'-triphosphate"}
{"X":15588,"RHEA_ID":12260,"DIRECTION":"UN","MASTER_ID":12260,"ec":"2.7.1.86","compounds":"ATP + NADH = ADP + H(+) + NADPH"}
{"X":15589,"RHEA_ID":12261,"DIRECTION":"LR","MASTER_ID":12260,"metacyc":"NADH-KINASE-RXN","compounds":"ATP + NADH => ADP + H(+) + NADPH"}
{"X":15590,"RHEA_ID":12262,"compounds":"ADP + H(+) + NADPH => ATP + NADH"}
{"X":15591,"RHEA_ID":22093,"compounds":"(3Z)-phycoerythrobilin + oxidized 2[4Fe-4S]-[ferredoxin] => 15,16-dihydrobiliverdin + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]"}
{"X":15592,"RHEA_ID":12264,"compounds":"2',4,4',6'-tetrahydroxychalcone + H(+) + O2 = aureusidin + H2O"}
{"X":15593,"RHEA_ID":12265,"compounds":"2',4,4',6'-tetrahydroxychalcone + H(+) + O2 => aureusidin + H2O"}
{"X":15594,"RHEA_ID":12266,"compounds":"aureusidin + H2O => 2',4,4',6'-tetrahydroxychalcone + H(+) + O2"}
{"X":15595,"RHEA_ID":22097,"compounds":"phosphate + RNA(n+1) => a ribonucleoside 5'-diphosphate + RNA(n)"}
{"X":15596,"RHEA_ID":12268,"DIRECTION":"UN","MASTER_ID":12268,"ec":"2.6.1.82","compounds":"2-oxoglutarate + putrescine = 1-pyrroline + H2O + L-glutamate"}
{"X":15597,"RHEA_ID":12269,"compounds":"2-oxoglutarate + putrescine => 1-pyrroline + H2O + L-glutamate"}
{"X":15598,"RHEA_ID":12270,"compounds":"1-pyrroline + H2O + L-glutamate => 2-oxoglutarate + putrescine"}
{"X":15599,"RHEA_ID":22101,"compounds":"3,5-dibromo-4-hydroxybenzonitrile + 2 H2O => 3,5-dibromo-4-hydroxybenzoate + NH4(+)"}
{"X":15600,"RHEA_ID":12272,"DIRECTION":"UN","MASTER_ID":12272,"ec":"4.1.1.28","compounds":"H(+) + L-dopa = CO2 + dopamine"}
{"X":15601,"RHEA_ID":12273,"DIRECTION":"LR","MASTER_ID":12272,"metacyc":"RXN66-221","reactome":"R-HSA-209924.1","compounds":"H(+) + L-dopa => CO2 + dopamine"}
{"X":15602,"RHEA_ID":12274,"compounds":"CO2 + dopamine => H(+) + L-dopa"}
{"X":15603,"RHEA_ID":22105,"compounds":"2-oxoglutarate + nicotianamine => 3''-deamino-3''-oxonicotianamine + L-glutamate"}
{"X":15604,"RHEA_ID":12276,"DIRECTION":"UN","MASTER_ID":12276,"ec":"1.3.8.4","compounds":"3-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = 3-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":15605,"RHEA_ID":12277,"DIRECTION":"LR","MASTER_ID":12276,"metacyc":"RXN0-2301","compounds":"3-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => 3-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":15606,"RHEA_ID":12278,"compounds":"3-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein] => 3-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":15607,"RHEA_ID":22109,"DIRECTION":"LR","MASTER_ID":22108,"ecocyc":"THREDEHYD-RXN","metacyc":"THREDEHYD-RXN","compounds":"L-threonine => 2-oxobutanoate + NH4(+)"}
{"X":15608,"RHEA_ID":12280,"DIRECTION":"UN","MASTER_ID":12280,"ec":"2.7.1.149","compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)"}
{"X":15609,"RHEA_ID":12281,"DIRECTION":"LR","MASTER_ID":12280,"metacyc":"2.7.1.149-RXN","compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)"}
{"X":15610,"RHEA_ID":12282,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP"}
{"X":15611,"RHEA_ID":22113,"compounds":"isoxazolin-5-one + O-acetyl-L-serine => 3-(5-oxoisoxazolin-2-yl)-L-alanine + acetate + H(+)"}
{"X":15612,"RHEA_ID":12284,"DIRECTION":"UN","MASTER_ID":12284,"ec":"2.8.3.13","compounds":"3-hydroxy-3-methylglutarate + succinyl-CoA = (3S)-hydroxy-3-methylglutaryl-CoA + succinate"}
{"X":15613,"RHEA_ID":12285,"compounds":"3-hydroxy-3-methylglutarate + succinyl-CoA => (3S)-hydroxy-3-methylglutaryl-CoA + succinate"}
{"X":15614,"RHEA_ID":12286,"compounds":"(3S)-hydroxy-3-methylglutaryl-CoA + succinate => 3-hydroxy-3-methylglutarate + succinyl-CoA"}
{"X":15615,"RHEA_ID":22117,"DIRECTION":"LR","MASTER_ID":22116,"metacyc":"2.4.1.191-RXN","compounds":"luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP-alpha-D-glucuronate => H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] 4'-O-beta-D-glucuronide + UDP"}
{"X":15616,"RHEA_ID":12288,"DIRECTION":"UN","MASTER_ID":12288,"ec":"3.2.1.51","compounds":"an alpha-L-fucoside + H2O = an alcohol + L-fucose"}
{"X":15617,"RHEA_ID":12289,"DIRECTION":"LR","MASTER_ID":12288,"metacyc":"ALPHA-L-FUCOSIDASE-RXN","compounds":"an alpha-L-fucoside + H2O => an alcohol + L-fucose"}
{"X":15618,"RHEA_ID":12290,"compounds":"an alcohol + L-fucose => an alpha-L-fucoside + H2O"}
{"X":15619,"RHEA_ID":12292,"DIRECTION":"UN","MASTER_ID":12292,"ec":"6.1.1.11","compounds":"ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)"}
{"X":15620,"RHEA_ID":12293,"DIRECTION":"LR","MASTER_ID":12292,"ecocyc":"SERINE--TRNA-LIGASE-RXN","metacyc":"SERINE--TRNA-LIGASE-RXN","compounds":"ATP + L-serine + tRNA(Ser) => AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)"}
{"X":15621,"RHEA_ID":12294,"compounds":"AMP + diphosphate + H(+) + L-seryl-tRNA(Ser) => ATP + L-serine + tRNA(Ser)"}
{"X":15622,"RHEA_ID":22125,"DIRECTION":"LR","MASTER_ID":22124,"metacyc":"RXN-8222","compounds":"17-O-acetylajmaline + H2O => acetate + ajmaline + H(+)"}
{"X":15623,"RHEA_ID":12296,"DIRECTION":"UN","MASTER_ID":12296,"ec":"4.3.3.4","metacyc":"4.3.3.4-RXN","compounds":"deacetylipecoside + H2O = dopamine + secologanin"}
{"X":15624,"RHEA_ID":12297,"compounds":"deacetylipecoside + H2O => dopamine + secologanin"}
{"X":15625,"RHEA_ID":12298,"compounds":"dopamine + secologanin => deacetylipecoside + H2O"}
{"X":15626,"RHEA_ID":22128,"DIRECTION":"UN","MASTER_ID":22128,"ec":"1.1.1.227","compounds":"(1S,2R,4S)-borneol + NAD(+) = (1S,4S)-camphor + H(+) + NADH"}
{"X":15627,"RHEA_ID":12300,"DIRECTION":"UN","MASTER_ID":12300,"ec":"2.5.1.25","compounds":"S-adenosyl-L-methionine + uridine(47) in tRNA(Phe) = 3-[(3S)-3-amino-3-carboxypropyl]-uridine(47) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine"}
{"X":15628,"RHEA_ID":12301,"DIRECTION":"LR","MASTER_ID":12300,"ecocyc":"2.5.1.25-RXN","metacyc":"2.5.1.25-RXN","compounds":"S-adenosyl-L-methionine + uridine(47) in tRNA(Phe) => 3-[(3S)-3-amino-3-carboxypropyl]-uridine(47) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine"}
{"X":15629,"RHEA_ID":12302,"compounds":"3-[(3S)-3-amino-3-carboxypropyl]-uridine(47) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine => S-adenosyl-L-methionine + uridine(47) in tRNA(Phe)"}
{"X":15630,"RHEA_ID":12303,"compounds":"S-adenosyl-L-methionine + uridine(47) in tRNA(Phe) <=> 3-[(3S)-3-amino-3-carboxypropyl]-uridine(47) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine"}
{"X":15631,"RHEA_ID":12304,"DIRECTION":"UN","MASTER_ID":12304,"ec":"1.2.1.31","compounds":"(S)-2-amino-6-oxohexanoate + H2O + NADP(+) = 2 H(+) + L-2-aminoadipate + NADPH"}
{"X":15632,"RHEA_ID":12305,"DIRECTION":"LR","MASTER_ID":12304,"metacyc":"1.2.1.31-RXN","compounds":"(S)-2-amino-6-oxohexanoate + H2O + NADP(+) => 2 H(+) + L-2-aminoadipate + NADPH"}
{"X":15633,"RHEA_ID":12306,"compounds":"2 H(+) + L-2-aminoadipate + NADPH => (S)-2-amino-6-oxohexanoate + H2O + NADP(+)"}
{"X":15634,"RHEA_ID":22136,"compounds":"7(1)-hydroxychlorophyllide a + H(+) + NADPH + O2 = chlorophyllide b + 2 H2O + NADP(+)"}
{"X":15635,"RHEA_ID":12308,"DIRECTION":"UN","MASTER_ID":12308,"ec":"1.2.1.31","compounds":"(S)-2-amino-6-oxohexanoate + H2O + NAD(+) = 2 H(+) + L-2-aminoadipate + NADH"}
{"X":15636,"RHEA_ID":12309,"DIRECTION":"LR","MASTER_ID":12308,"metacyc":"1.2.1.31-RXN","reactome":"R-HSA-70941.4","compounds":"(S)-2-amino-6-oxohexanoate + H2O + NAD(+) => 2 H(+) + L-2-aminoadipate + NADH"}
{"X":15637,"RHEA_ID":12310,"compounds":"2 H(+) + L-2-aminoadipate + NADH => (S)-2-amino-6-oxohexanoate + H2O + NAD(+)"}
{"X":15638,"RHEA_ID":22140,"DIRECTION":"UN","MASTER_ID":22140,"ec":"3.1.3.31","compounds":"a nucleoside 5'-phosphate + H2O = a nucleoside + phosphate"}
{"X":15639,"RHEA_ID":12312,"DIRECTION":"UN","MASTER_ID":12312,"ec":"1.14.14.22","compounds":"dibenzothiophene 5,5-dioxide + FMNH2 + NADH + O2 = 2'-hydroxybiphenyl-2-sulfinate + FMN + H(+) + H2O + NAD(+)"}
{"X":15640,"RHEA_ID":12313,"DIRECTION":"LR","MASTER_ID":12312,"metacyc":"RXN-623","compounds":"dibenzothiophene 5,5-dioxide + FMNH2 + NADH + O2 => 2'-hydroxybiphenyl-2-sulfinate + FMN + H(+) + H2O + NAD(+)"}
{"X":15641,"RHEA_ID":12314,"compounds":"2'-hydroxybiphenyl-2-sulfinate + FMN + H(+) + H2O + NAD(+) => dibenzothiophene 5,5-dioxide + FMNH2 + NADH + O2"}
{"X":15642,"RHEA_ID":22144,"compounds":"cis-aconitate + H2O = isocitrate"}
{"X":15643,"RHEA_ID":12316,"DIRECTION":"UN","MASTER_ID":12316,"ec":"3.1.3.64","compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}
{"X":15644,"RHEA_ID":12317,"DIRECTION":"LR","MASTER_ID":12316,"metacyc":"PHOSPHATIDYLINOSITOL-3-PHOSPHATASE-RXN","compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}
{"X":15645,"RHEA_ID":12318,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O"}
{"X":15646,"RHEA_ID":12320,"DIRECTION":"UN","MASTER_ID":12320,"ec":"1.3.1.73","compounds":"17-O-acetylnorajmaline + NADP(+) = 1,2-dihydrovomilenine + 2 H(+) + NADPH"}
{"X":15647,"RHEA_ID":12321,"compounds":"17-O-acetylnorajmaline + NADP(+) => 1,2-dihydrovomilenine + 2 H(+) + NADPH"}
{"X":15648,"RHEA_ID":12322,"DIRECTION":"RL","MASTER_ID":12320,"metacyc":"1.3.1.73-RXN","compounds":"1,2-dihydrovomilenine + 2 H(+) + NADPH => 17-O-acetylnorajmaline + NADP(+)"}
{"X":15649,"RHEA_ID":22152,"DIRECTION":"UN","MASTER_ID":22152,"ec":"1.1.5.2","compounds":"a ubiquinone + D-glucose = a ubiquinol + D-glucono-1,5-lactone"}
{"X":15650,"RHEA_ID":12324,"DIRECTION":"UN","MASTER_ID":12324,"ec":"3.2.2.11","compounds":"H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine = L-asparagine + N-acetyl-D-glucosamine"}
{"X":15651,"RHEA_ID":12325,"DIRECTION":"LR","MASTER_ID":12324,"metacyc":"3.2.2.11-RXN","compounds":"H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine => L-asparagine + N-acetyl-D-glucosamine"}
{"X":15652,"RHEA_ID":12326,"compounds":"L-asparagine + N-acetyl-D-glucosamine => H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine"}
{"X":15653,"RHEA_ID":22153,"DIRECTION":"LR","MASTER_ID":22152,"ecocyc":"GLUCDEHYDROG-RXN","metacyc":"GLUCDEHYDROG-RXN","compounds":"a ubiquinone + D-glucose => a ubiquinol + D-glucono-1,5-lactone"}
{"X":15654,"RHEA_ID":12328,"DIRECTION":"UN","MASTER_ID":12328,"ec":"2.4.1.334","metacyc":"RXN-15697","compounds":"[(1->3)-alpha-D-glucosyl](n) + phosphate = [(1->3)-alpha-D-glucosyl](n-1) + beta-D-glucose 1-phosphate"}
{"X":15655,"RHEA_ID":12329,"compounds":"[(1->3)-alpha-D-glucosyl](n) + phosphate => [(1->3)-alpha-D-glucosyl](n-1) + beta-D-glucose 1-phosphate"}
{"X":15656,"RHEA_ID":12330,"compounds":"[(1->3)-alpha-D-glucosyl](n-1) + beta-D-glucose 1-phosphate => [(1->3)-alpha-D-glucosyl](n) + phosphate"}
{"X":15657,"RHEA_ID":12331,"compounds":"[(1->3)-alpha-D-glucosyl](n) + phosphate <=> [(1->3)-alpha-D-glucosyl](n-1) + beta-D-glucose 1-phosphate"}
{"X":15658,"RHEA_ID":12332,"DIRECTION":"UN","MASTER_ID":12332,"ec":"7.2.2.7","compounds":"ATP + Fe(3+)(out) + H2O = ADP + Fe(3+)(in) + H(+) + phosphate"}
{"X":15659,"RHEA_ID":12333,"DIRECTION":"LR","MASTER_ID":12332,"metacyc":"3.6.3.30-RXN","compounds":"ATP + Fe(3+)(out) + H2O => ADP + Fe(3+)(in) + H(+) + phosphate"}
{"X":15660,"RHEA_ID":12334,"compounds":"ADP + Fe(3+)(in) + H(+) + phosphate => ATP + Fe(3+)(out) + H2O"}
{"X":15661,"RHEA_ID":12335,"compounds":"ATP + Fe(3+)(out) + H2O <=> ADP + Fe(3+)(in) + H(+) + phosphate"}
{"X":15662,"RHEA_ID":12336,"DIRECTION":"UN","MASTER_ID":12336,"ec":"4.2.99.12","metacyc":"CARBOXYMETHYLOXYSUCCINATE-LYASE-RXN","compounds":"carboxymethoxysuccinate = fumarate + glycolate"}
{"X":15663,"RHEA_ID":12337,"compounds":"carboxymethoxysuccinate => fumarate + glycolate"}
{"X":15664,"RHEA_ID":12338,"compounds":"fumarate + glycolate => carboxymethoxysuccinate"}
{"X":15665,"RHEA_ID":22165,"DIRECTION":"LR","MASTER_ID":22164,"metacyc":"2.4.1.88-RXN","compounds":"globoside Gb4Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => globoside Forssman (d18:1(4E)) + H(+) + UDP"}
{"X":15666,"RHEA_ID":12340,"DIRECTION":"UN","MASTER_ID":12340,"ec":"2.3.2.6","compounds":"L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein] = H(+) + N-terminal L-leucyl-L-lysyl-[protein] + tRNA(Leu)"}
{"X":15667,"RHEA_ID":12341,"DIRECTION":"LR","MASTER_ID":12340,"ecocyc":"LEUCYLTRANSFERASE-RXN","metacyc":"LEUCYLTRANSFERASE-RXN","compounds":"L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein] => H(+) + N-terminal L-leucyl-L-lysyl-[protein] + tRNA(Leu)"}
{"X":15668,"RHEA_ID":12342,"compounds":"H(+) + N-terminal L-leucyl-L-lysyl-[protein] + tRNA(Leu) => L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein]"}
{"X":15669,"RHEA_ID":12344,"DIRECTION":"UN","MASTER_ID":12344,"ec":"1.2.1.70","compounds":"(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = H(+) + L-glutamyl-tRNA(Glu) + NADPH"}
{"X":15670,"RHEA_ID":12345,"compounds":"(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) => H(+) + L-glutamyl-tRNA(Glu) + NADPH"}
{"X":15671,"RHEA_ID":12346,"DIRECTION":"RL","MASTER_ID":12344,"ecocyc":"GLUTRNAREDUCT-RXN","metacyc":"GLUTRNAREDUCT-RXN","compounds":"H(+) + L-glutamyl-tRNA(Glu) + NADPH => (S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu)"}
{"X":15672,"RHEA_ID":22173,"DIRECTION":"LR","MASTER_ID":22172,"metacyc":"SUCROSE-PHOSPHATE-SYNTHASE-RXN","compounds":"beta-D-fructose 6-phosphate + UDP-alpha-D-glucose => H(+) + sucrose 6(F)-phosphate + UDP"}
{"X":15673,"RHEA_ID":12348,"DIRECTION":"UN","MASTER_ID":12348,"ec":"5.3.3.4","compounds":"(S)-muconolactone = (4,5-dihydro-5-oxofuran-2-yl)-acetate"}
{"X":15674,"RHEA_ID":12349,"DIRECTION":"LR","MASTER_ID":12348,"metacyc":"MUCONOLACTONE-DELTA-ISOMERASE-RXN","compounds":"(S)-muconolactone => (4,5-dihydro-5-oxofuran-2-yl)-acetate"}
{"X":15675,"RHEA_ID":12350,"compounds":"(4,5-dihydro-5-oxofuran-2-yl)-acetate => (S)-muconolactone"}
{"X":15676,"RHEA_ID":22177,"DIRECTION":"LR","MASTER_ID":22176,"metacyc":"LEUKOTRIENE-B4-20-MONOOXYGENASE-RXN","compounds":"leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":15677,"RHEA_ID":12352,"compounds":"L-gulono-1,4-lactone + O2 = H2O2 + L-xylo-hex-3-ulonolactone"}
{"X":15678,"RHEA_ID":12353,"DIRECTION":"LR","MASTER_ID":12352,"metacyc":"L-GULONOLACTONE-OXIDASE-RXN","compounds":"L-gulono-1,4-lactone + O2 => H2O2 + L-xylo-hex-3-ulonolactone"}
{"X":15679,"RHEA_ID":12354,"compounds":"H2O2 + L-xylo-hex-3-ulonolactone => L-gulono-1,4-lactone + O2"}
{"X":15680,"RHEA_ID":22181,"compounds":"(S)-norreticuline + S-adenosyl-L-methionine => (S)-norcodamine + H(+) + S-adenosyl-L-homocysteine"}
{"X":15681,"RHEA_ID":12356,"DIRECTION":"UN","MASTER_ID":12356,"ec":"5.3.1.8","compounds":"D-mannose 6-phosphate = D-fructose 6-phosphate"}
{"X":15682,"RHEA_ID":12357,"compounds":"D-mannose 6-phosphate => D-fructose 6-phosphate"}
{"X":15683,"RHEA_ID":12358,"compounds":"D-fructose 6-phosphate => D-mannose 6-phosphate"}
{"X":15684,"RHEA_ID":22185,"compounds":"(+-)-trans-acenaphthene-1,2-diol + 2 NADP(+) => acenaphthene-1,2-dione + 2 H(+) + 2 NADPH"}
{"X":15685,"RHEA_ID":12360,"DIRECTION":"UN","MASTER_ID":12360,"ec":"2.3.1.93","compounds":"(2E)-2-methylbutenoyl-CoA + 13-hydroxylupanine = 13-(2-methylcrotonoyloxy)lupanine + CoA"}
{"X":15686,"RHEA_ID":12361,"DIRECTION":"LR","MASTER_ID":12360,"metacyc":"RXN-8694","compounds":"(2E)-2-methylbutenoyl-CoA + 13-hydroxylupanine => 13-(2-methylcrotonoyloxy)lupanine + CoA"}
{"X":15687,"RHEA_ID":12362,"compounds":"13-(2-methylcrotonoyloxy)lupanine + CoA => (2E)-2-methylbutenoyl-CoA + 13-hydroxylupanine"}
{"X":15688,"RHEA_ID":22188,"DIRECTION":"UN","MASTER_ID":22188,"ec":"3.8.1.9","compounds":"an (R)-2-haloacid + H2O = a (2S)-2-hydroxycarboxylate + a halide anion + H(+)"}
{"X":15689,"RHEA_ID":12364,"DIRECTION":"UN","MASTER_ID":12364,"ec":"1.10.5.1","compounds":"1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = a quinol + beta-nicotinamide D-riboside"}
{"X":15690,"RHEA_ID":12365,"compounds":"1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) => a quinol + beta-nicotinamide D-riboside"}
{"X":15691,"RHEA_ID":12366,"compounds":"a quinol + beta-nicotinamide D-riboside => 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+)"}
{"X":15692,"RHEA_ID":12368,"DIRECTION":"UN","MASTER_ID":12368,"ec":"1.1.99.4","compounds":"2-dehydro-D-gluconate + A = 2,5-didehydro-D-gluconate + AH2"}
{"X":15693,"RHEA_ID":12369,"DIRECTION":"LR","MASTER_ID":12368,"metacyc":"DEHYDROGLUCONATE-DEHYDROGENASE-RXN","compounds":"2-dehydro-D-gluconate + A => 2,5-didehydro-D-gluconate + AH2"}
{"X":15694,"RHEA_ID":12370,"compounds":"2,5-didehydro-D-gluconate + AH2 => 2-dehydro-D-gluconate + A"}
{"X":15695,"RHEA_ID":22196,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + AH2 + O2 = (6Z,9Z,12Z)-octadecatrienoyl-CoA + A + 2 H2O"}
{"X":15696,"RHEA_ID":12372,"DIRECTION":"UN","MASTER_ID":12372,"ec":"3.1.1.45","compounds":"2-(5-oxo-2,5-dihydrofuran-2-ylidene)acetate + H2O = 4-oxohex-2-enedioate + H(+)"}
{"X":15697,"RHEA_ID":12373,"DIRECTION":"LR","MASTER_ID":12372,"metacyc":"CARBOXYMETHYLENEBUTENOLIDASE-RXN","compounds":"2-(5-oxo-2,5-dihydrofuran-2-ylidene)acetate + H2O => 4-oxohex-2-enedioate + H(+)"}
{"X":15698,"RHEA_ID":12374,"compounds":"4-oxohex-2-enedioate + H(+) => 2-(5-oxo-2,5-dihydrofuran-2-ylidene)acetate + H2O"}
{"X":15699,"RHEA_ID":22200,"DIRECTION":"UN","MASTER_ID":22200,"ec":"2.1.1.145","compounds":"S-adenosyl-L-methionine + trans-aconitate = (E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine"}
{"X":15700,"RHEA_ID":12376,"DIRECTION":"UN","MASTER_ID":12376,"ec":"2.7.1.51","compounds":"ATP + L-fuculose = ADP + H(+) + L-fuculose 1-phosphate"}
{"X":15701,"RHEA_ID":12377,"DIRECTION":"LR","MASTER_ID":12376,"ecocyc":"FUCULOKIN-RXN","metacyc":"FUCULOKIN-RXN","compounds":"ATP + L-fuculose => ADP + H(+) + L-fuculose 1-phosphate"}
{"X":15702,"RHEA_ID":12378,"compounds":"ADP + H(+) + L-fuculose 1-phosphate => ATP + L-fuculose"}
{"X":15703,"RHEA_ID":22204,"DIRECTION":"UN","MASTER_ID":22204,"ec":"1.14.13.63","compounds":"3-hydroxyphenylacetate + H(+) + NADPH + O2 = H2O + homogentisate + NADP(+)"}
{"X":15704,"RHEA_ID":12380,"DIRECTION":"UN","MASTER_ID":12380,"ec":"2.6.1.46","compounds":"L-2,4-diaminobutanoate + pyruvate = L-alanine + L-aspartate 4-semialdehyde"}
{"X":15705,"RHEA_ID":12381,"compounds":"L-2,4-diaminobutanoate + pyruvate => L-alanine + L-aspartate 4-semialdehyde"}
{"X":15706,"RHEA_ID":12382,"compounds":"L-alanine + L-aspartate 4-semialdehyde => L-2,4-diaminobutanoate + pyruvate"}
{"X":15707,"RHEA_ID":22208,"DIRECTION":"UN","MASTER_ID":22208,"ec":"1.14.13.63","compounds":"3-hydroxyphenylacetate + H(+) + NADH + O2 = H2O + homogentisate + NAD(+)"}
{"X":15708,"RHEA_ID":12384,"DIRECTION":"UN","MASTER_ID":12384,"ec":"1.3.3.7","compounds":"5,6-dihydrouracil + O2 = H2O2 + uracil"}
{"X":15709,"RHEA_ID":12385,"DIRECTION":"LR","MASTER_ID":12384,"metacyc":"DIHYDROURACIL-OXIDASE-RXN","compounds":"5,6-dihydrouracil + O2 => H2O2 + uracil"}
{"X":15710,"RHEA_ID":12386,"compounds":"H2O2 + uracil => 5,6-dihydrouracil + O2"}
{"X":15711,"RHEA_ID":22212,"DIRECTION":"UN","MASTER_ID":22212,"ec":"5.1.2.5","metacyc":"TARTRATE-EPIMERASE-RXN","compounds":"(2R,3R)-tartrate = (2R,3S)-tartrate"}
{"X":15712,"RHEA_ID":12388,"DIRECTION":"UN","MASTER_ID":12388,"ec":"1.14.14.89","compounds":"formononetin + O2 + reduced [NADPH--hemoprotein reductase] = 2'-hydroxyformononetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":15713,"RHEA_ID":12388,"DIRECTION":"UN","MASTER_ID":12388,"ec":"1.14.14.90","compounds":"formononetin + O2 + reduced [NADPH--hemoprotein reductase] = 2'-hydroxyformononetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":15714,"RHEA_ID":12389,"DIRECTION":"LR","MASTER_ID":12388,"metacyc":"ISOFLAVONE-2-HYDROXYLASE-RXN","compounds":"formononetin + O2 + reduced [NADPH--hemoprotein reductase] => 2'-hydroxyformononetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":15715,"RHEA_ID":12390,"compounds":"2'-hydroxyformononetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => formononetin + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":15716,"RHEA_ID":22217,"DIRECTION":"LR","MASTER_ID":22216,"metacyc":"CAFFEATE-34-DIOXYGENASE-RXN","compounds":"(E)-caffeate + O2 => 3-(2-carboxyethenyl)-cis,cis-muconate + 2 H(+)"}
{"X":15717,"RHEA_ID":12396,"DIRECTION":"UN","MASTER_ID":12396,"ec":"1.1.1.186","metacyc":"DTDP-GALACTOSE-6-DEHYDROGENASE-RXN","compounds":"dTDP-D-galactose + H2O + 2 NADP(+) = dTDP-D-galacturonate + 3 H(+) + 2 NADPH"}
{"X":15718,"RHEA_ID":12397,"compounds":"dTDP-D-galactose + H2O + 2 NADP(+) => dTDP-D-galacturonate + 3 H(+) + 2 NADPH"}
{"X":15719,"RHEA_ID":12398,"compounds":"dTDP-D-galacturonate + 3 H(+) + 2 NADPH => dTDP-D-galactose + H2O + 2 NADP(+)"}
{"X":15720,"RHEA_ID":22221,"DIRECTION":"LR","MASTER_ID":22220,"metacyc":"4.2.3.19-RXN","compounds":"ent-copalyl diphosphate => diphosphate + ent-kaur-16-ene"}
{"X":15721,"RHEA_ID":12400,"DIRECTION":"UN","MASTER_ID":12400,"ec":"3.5.1.42","compounds":"beta-nicotinamide D-ribonucleotide + H2O = NH4(+) + nicotinate beta-D-ribonucleotide"}
{"X":15722,"RHEA_ID":12401,"DIRECTION":"LR","MASTER_ID":12400,"ecocyc":"NMNAMIDOHYDRO-RXN","metacyc":"NMNAMIDOHYDRO-RXN","compounds":"beta-nicotinamide D-ribonucleotide + H2O => NH4(+) + nicotinate beta-D-ribonucleotide"}
{"X":15723,"RHEA_ID":12402,"compounds":"NH4(+) + nicotinate beta-D-ribonucleotide => beta-nicotinamide D-ribonucleotide + H2O"}
{"X":15724,"RHEA_ID":22225,"DIRECTION":"LR","MASTER_ID":22224,"metacyc":"2.3.1.159-RXN","compounds":"3 H(+) + 3 malonyl-CoA + N-methylanthraniloyl-CoA => 1,3-dihydroxy-N-methylacridone + 3 CO2 + 4 CoA + H2O"}
{"X":15725,"RHEA_ID":12404,"DIRECTION":"UN","MASTER_ID":12404,"ec":"2.4.1.22","compounds":"D-glucose + UDP-alpha-D-galactose = H(+) + lactose + UDP"}
{"X":15726,"RHEA_ID":12405,"compounds":"D-glucose + UDP-alpha-D-galactose => H(+) + lactose + UDP"}
{"X":15727,"RHEA_ID":12406,"compounds":"H(+) + lactose + UDP => D-glucose + UDP-alpha-D-galactose"}
{"X":15728,"RHEA_ID":22229,"DIRECTION":"LR","MASTER_ID":22228,"metacyc":"RXN-13162","compounds":"H(+) + NADH + presqualene diphosphate => diphosphate + NAD(+) + squalene"}
{"X":15729,"RHEA_ID":12408,"DIRECTION":"UN","MASTER_ID":12408,"ec":"1.4.1.18","compounds":"L-lysine + NAD(+) = 2 H(+) + L-1-piperideine-6-carboxylate + NADH + NH4(+)"}
{"X":15730,"RHEA_ID":12409,"compounds":"L-lysine + NAD(+) => 2 H(+) + L-1-piperideine-6-carboxylate + NADH + NH4(+)"}
{"X":15731,"RHEA_ID":12410,"compounds":"2 H(+) + L-1-piperideine-6-carboxylate + NADH + NH4(+) => L-lysine + NAD(+)"}
{"X":15732,"RHEA_ID":22233,"DIRECTION":"LR","MASTER_ID":22232,"metacyc":"RXN-13724","reactome":"R-HSA-191402.1","compounds":"H(+) + NADPH + presqualene diphosphate => diphosphate + NADP(+) + squalene"}
{"X":15733,"RHEA_ID":12412,"DIRECTION":"UN","MASTER_ID":12412,"ec":"3.1.3.38","compounds":"(2R)-3-phosphoglycerate + H2O = (R)-glycerate + phosphate"}
{"X":15734,"RHEA_ID":12413,"DIRECTION":"LR","MASTER_ID":12412,"metacyc":"3-PHOSPHOGLYCERATE-PHOSPHATASE-RXN","compounds":"(2R)-3-phosphoglycerate + H2O => (R)-glycerate + phosphate"}
{"X":15735,"RHEA_ID":12414,"compounds":"(R)-glycerate + phosphate => (2R)-3-phosphoglycerate + H2O"}
{"X":15736,"RHEA_ID":22237,"DIRECTION":"LR","MASTER_ID":22236,"ecocyc":"3.1.3.68-RXN","metacyc":"3.1.3.68-RXN","compounds":"2-deoxy-D-glucose 6-phosphate + H2O => 2-deoxy-D-glucose + phosphate"}
{"X":15737,"RHEA_ID":12416,"DIRECTION":"UN","MASTER_ID":12416,"ec":"4.3.1.6","compounds":"beta-alanyl-CoA = acryloyl-CoA + NH4(+)"}
{"X":15738,"RHEA_ID":12417,"compounds":"beta-alanyl-CoA => acryloyl-CoA + NH4(+)"}
{"X":15739,"RHEA_ID":12418,"compounds":"acryloyl-CoA + NH4(+) => beta-alanyl-CoA"}
{"X":15740,"RHEA_ID":22241,"DIRECTION":"LR","MASTER_ID":22240,"metacyc":"RXN-13199","compounds":"H2O + methylenediurea => N-(carboxyaminomethyl)urea + NH4(+)"}
{"X":15741,"RHEA_ID":12420,"DIRECTION":"UN","MASTER_ID":12420,"ec":"2.7.1.144","compounds":"ATP + D-tagatofuranose 6-phosphate = ADP + D-tagatofuranose 1,6-bisphosphate + H(+)"}
{"X":15742,"RHEA_ID":12421,"DIRECTION":"LR","MASTER_ID":12420,"ecocyc":"TAGAKIN-RXN","metacyc":"TAGAKIN-RXN","compounds":"ATP + D-tagatofuranose 6-phosphate => ADP + D-tagatofuranose 1,6-bisphosphate + H(+)"}
{"X":15743,"RHEA_ID":12422,"compounds":"ADP + D-tagatofuranose 1,6-bisphosphate + H(+) => ATP + D-tagatofuranose 6-phosphate"}
{"X":15744,"RHEA_ID":22245,"compounds":"kaempferol + UDP-alpha-D-xylose => H(+) + kaempferol 3-O-beta-D-xyloside + UDP"}
{"X":15745,"RHEA_ID":12424,"DIRECTION":"UN","MASTER_ID":12424,"ec":"4.3.1.16","compounds":"(3S)-3-hydroxy-L-aspartate = NH4(+) + oxaloacetate"}
{"X":15746,"RHEA_ID":12425,"compounds":"(3S)-3-hydroxy-L-aspartate => NH4(+) + oxaloacetate"}
{"X":15747,"RHEA_ID":12426,"compounds":"NH4(+) + oxaloacetate => (3S)-3-hydroxy-L-aspartate"}
{"X":15748,"RHEA_ID":22249,"compounds":"7,8-dihydro-7,8-dihydroxykynurenate + NAD(+) => 7,8-dihydroxykynurenate + H(+) + NADH"}
{"X":15749,"RHEA_ID":12428,"DIRECTION":"UN","MASTER_ID":12428,"ec":"1.6.5.7","compounds":"2-hydroxy-1,4-benzoquinone + 2 H(+) + NADH = benzene-1,2,4-triol + NAD(+)"}
{"X":15750,"RHEA_ID":12429,"DIRECTION":"LR","MASTER_ID":12428,"metacyc":"1.6.5.7-RXN","compounds":"2-hydroxy-1,4-benzoquinone + 2 H(+) + NADH => benzene-1,2,4-triol + NAD(+)"}
{"X":15751,"RHEA_ID":12430,"compounds":"benzene-1,2,4-triol + NAD(+) => 2-hydroxy-1,4-benzoquinone + 2 H(+) + NADH"}
{"X":15752,"RHEA_ID":22253,"compounds":"globoside Gb3Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => globoside Gb4Cer (d18:1(4E)) + H(+) + UDP"}
{"X":15753,"RHEA_ID":12432,"DIRECTION":"UN","MASTER_ID":12432,"ec":"2.3.2.10","compounds":"L-alanyl-tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine = H(+) + tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-N(6)-(L-alanyl)-L-lysyl-D-alanyl-D-alanine"}
{"X":15754,"RHEA_ID":12433,"DIRECTION":"LR","MASTER_ID":12432,"metacyc":"2.3.2.10-RXN","compounds":"L-alanyl-tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine => H(+) + tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-N(6)-(L-alanyl)-L-lysyl-D-alanyl-D-alanine"}
{"X":15755,"RHEA_ID":12434,"compounds":"H(+) + tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-N(6)-(L-alanyl)-L-lysyl-D-alanyl-D-alanine => L-alanyl-tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine"}
{"X":15756,"RHEA_ID":12436,"DIRECTION":"UN","MASTER_ID":12436,"ec":"2.3.1.138","metacyc":"2.3.1.138-RXN","compounds":"caffeoyl-CoA + putrescine = CoA + H(+) + N-caffeoylputrescine"}
{"X":15757,"RHEA_ID":12437,"compounds":"caffeoyl-CoA + putrescine => CoA + H(+) + N-caffeoylputrescine"}
{"X":15758,"RHEA_ID":12438,"compounds":"CoA + H(+) + N-caffeoylputrescine => caffeoyl-CoA + putrescine"}
{"X":15759,"RHEA_ID":22261,"DIRECTION":"LR","MASTER_ID":22260,"metacyc":"TRIACETATE-LACTONASE-RXN","compounds":"H2O + triacetate lactone => H(+) + triacetate"}
{"X":15760,"RHEA_ID":12440,"DIRECTION":"UN","MASTER_ID":12440,"ec":"1.5.1.7","compounds":"H2O + L-saccharopine + NAD(+) = 2-oxoglutarate + H(+) + L-lysine + NADH"}
{"X":15761,"RHEA_ID":12441,"DIRECTION":"LR","MASTER_ID":12440,"metacyc":"1.5.1.7-RXN","compounds":"H2O + L-saccharopine + NAD(+) => 2-oxoglutarate + H(+) + L-lysine + NADH"}
{"X":15762,"RHEA_ID":12442,"compounds":"2-oxoglutarate + H(+) + L-lysine + NADH => H2O + L-saccharopine + NAD(+)"}
{"X":15763,"RHEA_ID":22269,"DIRECTION":"LR","MASTER_ID":22268,"metacyc":"STREPTOMYCIN-6-KINASE-RXN","compounds":"ATP + streptomycin => ADP + H(+) + streptomycin 6-phosphate"}
{"X":15764,"RHEA_ID":12444,"DIRECTION":"UN","MASTER_ID":12444,"ec":"1.3.1.27","compounds":"hexadecanal + NADP(+) = (2E)-hexadecenal + H(+) + NADPH"}
{"X":15765,"RHEA_ID":12445,"compounds":"hexadecanal + NADP(+) => (2E)-hexadecenal + H(+) + NADPH"}
{"X":15766,"RHEA_ID":12446,"DIRECTION":"RL","MASTER_ID":12444,"metacyc":"2-HEXADECENAL-REDUCTASE-RXN","compounds":"(2E)-hexadecenal + H(+) + NADPH => hexadecanal + NADP(+)"}
{"X":15767,"RHEA_ID":22273,"DIRECTION":"LR","MASTER_ID":22272,"metacyc":"RXN-14978","compounds":"(20S)-protopanaxadiol + O2 + reduced [NADPH--hemoprotein reductase] => (20S)-protopanaxatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":15768,"RHEA_ID":12448,"DIRECTION":"UN","MASTER_ID":12448,"ec":"3.5.1.22","metacyc":"PANTOTHENASE-RXN","compounds":"(R)-pantothenate + H2O = (R)-pantoate + beta-alanine"}
{"X":15769,"RHEA_ID":12449,"compounds":"(R)-pantothenate + H2O => (R)-pantoate + beta-alanine"}
{"X":15770,"RHEA_ID":12450,"compounds":"(R)-pantoate + beta-alanine => (R)-pantothenate + H2O"}
{"X":15771,"RHEA_ID":22277,"compounds":"2-oxoaldehyde + H2O + NAD(+) => a 2-oxocarboxylate + 2 H(+) + NADH"}
{"X":15772,"RHEA_ID":12452,"DIRECTION":"UN","MASTER_ID":12452,"ec":"2.7.1.134","compounds":"1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)"}
{"X":15773,"RHEA_ID":12453,"DIRECTION":"LR","MASTER_ID":12452,"metacyc":"2.7.1.134-RXN","reactome":"R-HSA-1855162.2","compounds":"1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)"}
{"X":15774,"RHEA_ID":12453,"DIRECTION":"LR","MASTER_ID":12452,"metacyc":"2.7.1.134-RXN","reactome":"R-HSA-994137.3","compounds":"1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)"}
{"X":15775,"RHEA_ID":12454,"compounds":"1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+) => 1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP"}
{"X":15776,"RHEA_ID":22282,"compounds":"H(+) + puromycin + S-adenosyl-L-homocysteine => O-demethylpuromycin + S-adenosyl-L-methionine"}
{"X":15777,"RHEA_ID":12456,"DIRECTION":"UN","MASTER_ID":12456,"ec":"2.7.7.40","compounds":"CTP + D-ribitol 5-phosphate + H(+) = CDP-L-ribitol + diphosphate"}
{"X":15778,"RHEA_ID":12457,"compounds":"CTP + D-ribitol 5-phosphate + H(+) => CDP-L-ribitol + diphosphate"}
{"X":15779,"RHEA_ID":12458,"compounds":"CDP-L-ribitol + diphosphate => CTP + D-ribitol 5-phosphate + H(+)"}
{"X":15780,"RHEA_ID":22286,"compounds":"CO2 + NH4(+) + putrescine => 2 H(+) + H2O + N-carbamoylputrescine"}
{"X":15781,"RHEA_ID":12460,"DIRECTION":"UN","MASTER_ID":12460,"ec":"4.2.1.2","compounds":"(S)-malate = fumarate + H2O"}
{"X":15782,"RHEA_ID":12461,"DIRECTION":"LR","MASTER_ID":12460,"reactome":"R-HSA-451033.3","compounds":"(S)-malate => fumarate + H2O"}
{"X":15783,"RHEA_ID":12462,"DIRECTION":"RL","MASTER_ID":12460,"reactome":"R-HSA-70982.3","compounds":"fumarate + H2O => (S)-malate"}
{"X":15784,"RHEA_ID":22290,"compounds":"an oligoglycosyl-(1->4)-beta-D-glucose + N-acyl-sphingoid base => an oligoglycosyl-(1->4)-glucosyl-(1<->1)-ceramide + H2O"}
{"X":15785,"RHEA_ID":12464,"DIRECTION":"UN","MASTER_ID":12464,"ec":"2.4.1.123","compounds":"myo-inositol + UDP-alpha-D-galactose = alpha-D-galactosyl-(1->3)-1D-myo-inositol + H(+) + UDP"}
{"X":15786,"RHEA_ID":12465,"DIRECTION":"LR","MASTER_ID":12464,"metacyc":"2.4.1.123-RXN","compounds":"myo-inositol + UDP-alpha-D-galactose => alpha-D-galactosyl-(1->3)-1D-myo-inositol + H(+) + UDP"}
{"X":15787,"RHEA_ID":12466,"compounds":"alpha-D-galactosyl-(1->3)-1D-myo-inositol + H(+) + UDP => myo-inositol + UDP-alpha-D-galactose"}
{"X":15788,"RHEA_ID":22294,"compounds":"biphenyl-3,5-diol + 4 CO2 + 4 CoA => benzoyl-CoA + 3 H(+) + 3 malonyl-CoA"}
{"X":15789,"RHEA_ID":12468,"compounds":"avenacoside A + H2O = 26-desgluco-avenacoside A + D-glucose"}
{"X":15790,"RHEA_ID":12469,"compounds":"avenacoside A + H2O => 26-desgluco-avenacoside A + D-glucose"}
{"X":15791,"RHEA_ID":12470,"compounds":"26-desgluco-avenacoside A + D-glucose => avenacoside A + H2O"}
{"X":15792,"RHEA_ID":12471,"DIRECTION":"BI","MASTER_ID":12468,"metacyc":"RXN-14980","compounds":"avenacoside A + H2O <=> 26-desgluco-avenacoside A + D-glucose"}
{"X":15793,"RHEA_ID":12472,"DIRECTION":"UN","MASTER_ID":12472,"ec":"1.4.3.19","compounds":"H2O + N-ethylglycine + O2 = ethylamine + glyoxylate + H2O2"}
{"X":15794,"RHEA_ID":12473,"DIRECTION":"LR","MASTER_ID":12472,"metacyc":"RXN-8674","compounds":"H2O + N-ethylglycine + O2 => ethylamine + glyoxylate + H2O2"}
{"X":15795,"RHEA_ID":12474,"compounds":"ethylamine + glyoxylate + H2O2 => H2O + N-ethylglycine + O2"}
{"X":15796,"RHEA_ID":12476,"DIRECTION":"UN","MASTER_ID":12476,"ec":"3.5.1.68","compounds":"H2O + N-formyl-L-glutamate = formate + L-glutamate"}
{"X":15797,"RHEA_ID":12477,"DIRECTION":"LR","MASTER_ID":12476,"metacyc":"N-FORMYLGLUTAMATE-DEFORMYLASE-RXN","compounds":"H2O + N-formyl-L-glutamate => formate + L-glutamate"}
{"X":15798,"RHEA_ID":12478,"compounds":"formate + L-glutamate => H2O + N-formyl-L-glutamate"}
{"X":15799,"RHEA_ID":22306,"compounds":"5-dehydro-D-fructose + AH2 => A + D-fructose"}
{"X":15800,"RHEA_ID":12480,"DIRECTION":"UN","MASTER_ID":12480,"ec":"2.6.1.43","compounds":"5-aminolevulinate + pyruvate = 4,5-dioxopentanoate + L-alanine"}
{"X":15801,"RHEA_ID":12481,"compounds":"5-aminolevulinate + pyruvate => 4,5-dioxopentanoate + L-alanine"}
{"X":15802,"RHEA_ID":12482,"compounds":"4,5-dioxopentanoate + L-alanine => 5-aminolevulinate + pyruvate"}
{"X":15803,"RHEA_ID":22310,"compounds":"D-xylose + H2O2 => O2 + xylitol"}
{"X":15804,"RHEA_ID":12484,"DIRECTION":"UN","MASTER_ID":12484,"ec":"3.1.3.5","compounds":"a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate"}
{"X":15805,"RHEA_ID":12485,"DIRECTION":"LR","MASTER_ID":12484,"ecocyc":"5-NUCLEOTID-RXN","metacyc":"5-NUCLEOTID-RXN","compounds":"a ribonucleoside 5'-phosphate + H2O => a ribonucleoside + phosphate"}
{"X":15806,"RHEA_ID":12486,"compounds":"a ribonucleoside + phosphate => a ribonucleoside 5'-phosphate + H2O"}
{"X":15807,"RHEA_ID":12488,"DIRECTION":"UN","MASTER_ID":12488,"ec":"4.3.1.9","compounds":"2-amino-2-deoxy-D-gluconate = 2-dehydro-3-deoxy-D-gluconate + NH4(+)"}
{"X":15808,"RHEA_ID":12489,"compounds":"2-amino-2-deoxy-D-gluconate => 2-dehydro-3-deoxy-D-gluconate + NH4(+)"}
{"X":15809,"RHEA_ID":12490,"compounds":"2-dehydro-3-deoxy-D-gluconate + NH4(+) => 2-amino-2-deoxy-D-gluconate"}
{"X":15810,"RHEA_ID":22318,"compounds":"13-(beta-D-glucosyloxy)docosanoate + H(+) + UDP => 13-hydroxydocosanoate + UDP-alpha-D-glucose"}
{"X":15811,"RHEA_ID":12492,"DIRECTION":"UN","MASTER_ID":12492,"ec":"5.1.1.2","metacyc":"METHIONINE-RACEMASE-RXN","compounds":"L-methionine = D-methionine"}
{"X":15812,"RHEA_ID":12493,"compounds":"L-methionine => D-methionine"}
{"X":15813,"RHEA_ID":12494,"compounds":"D-methionine => L-methionine"}
{"X":15814,"RHEA_ID":22322,"compounds":"D-maltose + 2 phosphate => 2 alpha-D-glucose 1-phosphate + H2O"}
{"X":15815,"RHEA_ID":12496,"compounds":"2 Fe(2+) + 4 H2O + O2 = 6 H(+) + H2O2 + 2 iron(III) oxide-hydroxide"}
{"X":15816,"RHEA_ID":12497,"DIRECTION":"LR","MASTER_ID":12496,"ecocyc":"RXN-15292","metacyc":"RXN-15292","compounds":"2 Fe(2+) + 4 H2O + O2 => 6 H(+) + H2O2 + 2 iron(III) oxide-hydroxide"}
{"X":15817,"RHEA_ID":12498,"compounds":"6 H(+) + H2O2 + 2 iron(III) oxide-hydroxide => 2 Fe(2+) + 4 H2O + O2"}
{"X":15818,"RHEA_ID":12499,"compounds":"2 Fe(2+) + 4 H2O + O2 <=> 6 H(+) + H2O2 + 2 iron(III) oxide-hydroxide"}
{"X":15819,"RHEA_ID":12500,"DIRECTION":"UN","MASTER_ID":12500,"ec":"1.5.1.25","compounds":"NADP(+) + thiomorpholine-3-carboxylate = 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADPH"}
{"X":15820,"RHEA_ID":12501,"compounds":"NADP(+) + thiomorpholine-3-carboxylate => 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADPH"}
{"X":15821,"RHEA_ID":12502,"DIRECTION":"RL","MASTER_ID":12500,"metacyc":"1.5.1.25-RXN","compounds":"3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADPH => NADP(+) + thiomorpholine-3-carboxylate"}
{"X":15822,"RHEA_ID":22330,"compounds":"diphosphate + thiamine phosphate => 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+)"}
{"X":15823,"RHEA_ID":12504,"DIRECTION":"UN","MASTER_ID":12504,"ec":"1.5.1.25","compounds":"NAD(+) + thiomorpholine-3-carboxylate = 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADH"}
{"X":15824,"RHEA_ID":12505,"compounds":"NAD(+) + thiomorpholine-3-carboxylate => 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADH"}
{"X":15825,"RHEA_ID":12506,"DIRECTION":"RL","MASTER_ID":12504,"metacyc":"1.5.1.25-RXN","compounds":"3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADH => NAD(+) + thiomorpholine-3-carboxylate"}
{"X":15826,"RHEA_ID":22334,"compounds":"2-methylmaleate + H2O => (3R)-citramalate"}
{"X":15827,"RHEA_ID":12508,"DIRECTION":"UN","MASTER_ID":12508,"ec":"2.1.1.50","compounds":"loganate + S-adenosyl-L-methionine = loganin + S-adenosyl-L-homocysteine"}
{"X":15828,"RHEA_ID":12509,"DIRECTION":"LR","MASTER_ID":12508,"metacyc":"LOGANATE-O-METHYLTRANSFERASE-RXN","compounds":"loganate + S-adenosyl-L-methionine => loganin + S-adenosyl-L-homocysteine"}
{"X":15829,"RHEA_ID":12510,"compounds":"loganin + S-adenosyl-L-homocysteine => loganate + S-adenosyl-L-methionine"}
{"X":15830,"RHEA_ID":22338,"compounds":"L-methionine + N,N-dimethylglycine => betaine + L-homocysteine"}
{"X":15831,"RHEA_ID":12512,"DIRECTION":"UN","MASTER_ID":12512,"ec":"1.4.3.1","compounds":"D-aspartate + H2O + O2 = H2O2 + NH4(+) + oxaloacetate"}
{"X":15832,"RHEA_ID":12512,"DIRECTION":"UN","MASTER_ID":12512,"ec":"1.4.3.15","compounds":"D-aspartate + H2O + O2 = H2O2 + NH4(+) + oxaloacetate"}
{"X":15833,"RHEA_ID":12513,"DIRECTION":"LR","MASTER_ID":12512,"metacyc":"D-ASPARTATE-OXIDASE-RXN","reactome":"R-HSA-6810076.2","compounds":"D-aspartate + H2O + O2 => H2O2 + NH4(+) + oxaloacetate"}
{"X":15834,"RHEA_ID":12514,"compounds":"H2O2 + NH4(+) + oxaloacetate => D-aspartate + H2O + O2"}
{"X":15835,"RHEA_ID":32933,"compounds":"a cardiolipin + CMP + H(+) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a CDP-1,2-diacyl-sn-glycerol"}
{"X":15836,"RHEA_ID":12516,"DIRECTION":"UN","MASTER_ID":12516,"ec":"4.2.3.23","compounds":"(2E,6E)-farnesyl diphosphate = (+)-(R)-germacrene A + diphosphate"}
{"X":15837,"RHEA_ID":12517,"DIRECTION":"LR","MASTER_ID":12516,"metacyc":"RXN-11527","compounds":"(2E,6E)-farnesyl diphosphate => (+)-(R)-germacrene A + diphosphate"}
{"X":15838,"RHEA_ID":12518,"compounds":"(+)-(R)-germacrene A + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":15839,"RHEA_ID":32937,"compounds":"1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+) => a cardiolipin + H2O"}
{"X":15840,"RHEA_ID":12520,"compounds":"L-dopa = (E)-caffeate + NH4(+)"}
{"X":15841,"RHEA_ID":12521,"DIRECTION":"LR","MASTER_ID":12520,"metacyc":"RXN-14987","compounds":"L-dopa => (E)-caffeate + NH4(+)"}
{"X":15842,"RHEA_ID":12522,"compounds":"(E)-caffeate + NH4(+) => L-dopa"}
{"X":15843,"RHEA_ID":12523,"compounds":"L-dopa <=> (E)-caffeate + NH4(+)"}
{"X":15844,"RHEA_ID":12524,"DIRECTION":"UN","MASTER_ID":12524,"ec":"1.5.1.1","compounds":"L-pipecolate + NADP(+) = Delta(1)-piperideine-2-carboxylate + H(+) + NADPH"}
{"X":15845,"RHEA_ID":12524,"DIRECTION":"UN","MASTER_ID":12524,"ec":"1.5.1.21","compounds":"L-pipecolate + NADP(+) = Delta(1)-piperideine-2-carboxylate + H(+) + NADPH"}
{"X":15846,"RHEA_ID":12525,"compounds":"L-pipecolate + NADP(+) => Delta(1)-piperideine-2-carboxylate + H(+) + NADPH"}
{"X":15847,"RHEA_ID":12526,"DIRECTION":"RL","MASTER_ID":12524,"metacyc":"RXN-19250","reactome":"R-HSA-5693347.1","compounds":"Delta(1)-piperideine-2-carboxylate + H(+) + NADPH => L-pipecolate + NADP(+)"}
{"X":15848,"RHEA_ID":12526,"DIRECTION":"RL","MASTER_ID":12524,"metacyc":"RXN-8166","reactome":"R-HSA-5693347.1","compounds":"Delta(1)-piperideine-2-carboxylate + H(+) + NADPH => L-pipecolate + NADP(+)"}
{"X":15849,"RHEA_ID":22357,"compounds":"diphosphate + oxaloacetate => CO2 + phosphate + phosphoenolpyruvate"}
{"X":15850,"RHEA_ID":12528,"DIRECTION":"UN","MASTER_ID":12528,"ec":"2.4.1.212","compounds":"N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP-alpha-D-glucuronate = [hyaluronan](n+1) + H(+) + UDP"}
{"X":15851,"RHEA_ID":12529,"compounds":"N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP-alpha-D-glucuronate => [hyaluronan](n+1) + H(+) + UDP"}
{"X":15852,"RHEA_ID":12530,"compounds":"[hyaluronan](n+1) + H(+) + UDP => N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP-alpha-D-glucuronate"}
{"X":15853,"RHEA_ID":12531,"DIRECTION":"BI","MASTER_ID":12528,"metacyc":"2.4.1.212-RXN","compounds":"N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP-alpha-D-glucuronate <=> [hyaluronan](n+1) + H(+) + UDP"}
{"X":15854,"RHEA_ID":12532,"DIRECTION":"UN","MASTER_ID":12532,"ec":"2.8.4.1","compounds":"coenzyme B + methyl-coenzyme M = coenzyme M-coenzyme B heterodisulfide + methane"}
{"X":15855,"RHEA_ID":12533,"DIRECTION":"LR","MASTER_ID":12532,"macie":"M0156","compounds":"coenzyme B + methyl-coenzyme M => coenzyme M-coenzyme B heterodisulfide + methane"}
{"X":15856,"RHEA_ID":12534,"compounds":"coenzyme M-coenzyme B heterodisulfide + methane => coenzyme B + methyl-coenzyme M"}
{"X":15857,"RHEA_ID":22364,"DIRECTION":"UN","MASTER_ID":22364,"ec":"1.1.1.282","compounds":"L-quinate + NAD(+) = 3-dehydroquinate + H(+) + NADH"}
{"X":15858,"RHEA_ID":12536,"DIRECTION":"UN","MASTER_ID":12536,"ec":"4.2.1.91","compounds":"H(+) + L-arogenate = CO2 + H2O + L-phenylalanine"}
{"X":15859,"RHEA_ID":12537,"DIRECTION":"LR","MASTER_ID":12536,"metacyc":"CARBOXYCYCLOHEXADIENYL-DEHYDRATASE-RXN","compounds":"H(+) + L-arogenate => CO2 + H2O + L-phenylalanine"}
{"X":15860,"RHEA_ID":12538,"compounds":"CO2 + H2O + L-phenylalanine => H(+) + L-arogenate"}
{"X":15861,"RHEA_ID":32959,"compounds":"H2O + L-isoleucine + NAD(+) = (S)-3-methyl-2-oxopentanoate + H(+) + NADH + NH4(+)"}
{"X":15862,"RHEA_ID":12540,"DIRECTION":"UN","MASTER_ID":12540,"ec":"6.1.1.7","compounds":"ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)"}
{"X":15863,"RHEA_ID":12541,"DIRECTION":"LR","MASTER_ID":12540,"ecocyc":"ALANINE--TRNA-LIGASE-RXN","metacyc":"ALANINE--TRNA-LIGASE-RXN","compounds":"ATP + L-alanine + tRNA(Ala) => AMP + diphosphate + L-alanyl-tRNA(Ala)"}
{"X":15864,"RHEA_ID":12542,"compounds":"AMP + diphosphate + L-alanyl-tRNA(Ala) => ATP + L-alanine + tRNA(Ala)"}
{"X":15865,"RHEA_ID":32963,"DIRECTION":"UN","MASTER_ID":32963,"ec":"3.5.1.111","compounds":"2-oxoglutaramate + H2O = 2-oxoglutarate + NH4(+)"}
{"X":15866,"RHEA_ID":12544,"DIRECTION":"UN","MASTER_ID":12544,"ec":"6.3.5.9","compounds":"2 ATP + 2 H2O + hydrogenobyrinate + 2 L-glutamine = 2 ADP + 2 H(+) + hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 phosphate"}
{"X":15867,"RHEA_ID":12545,"compounds":"2 ATP + 2 H2O + hydrogenobyrinate + 2 L-glutamine => 2 ADP + 2 H(+) + hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 phosphate"}
{"X":15868,"RHEA_ID":12546,"compounds":"2 ADP + 2 H(+) + hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 phosphate => 2 ATP + 2 H2O + hydrogenobyrinate + 2 L-glutamine"}
{"X":15869,"RHEA_ID":12548,"DIRECTION":"UN","MASTER_ID":12548,"ec":"1.1.1.288","compounds":"2-cis,4-trans-xanthoxin + NAD(+) = 2-cis-(+)-abscisic aldehyde + H(+) + NADH"}
{"X":15870,"RHEA_ID":12549,"DIRECTION":"LR","MASTER_ID":12548,"metacyc":"1.1.1.288-RXN","compounds":"2-cis,4-trans-xanthoxin + NAD(+) => 2-cis-(+)-abscisic aldehyde + H(+) + NADH"}
{"X":15871,"RHEA_ID":12550,"compounds":"2-cis-(+)-abscisic aldehyde + H(+) + NADH => 2-cis,4-trans-xanthoxin + NAD(+)"}
{"X":15872,"RHEA_ID":22379,"compounds":"uridine(38/39/40) in tRNA <=> pseudouridine(38/39/40) in tRNA"}
{"X":15873,"RHEA_ID":12552,"DIRECTION":"UN","MASTER_ID":12552,"ec":"2.3.1.146","compounds":"(E)-cinnamoyl-CoA + 3 H(+) + 3 malonyl-CoA = (E)-pinosylvin + 4 CO2 + 4 CoA"}
{"X":15874,"RHEA_ID":12553,"DIRECTION":"LR","MASTER_ID":12552,"metacyc":"PINOSYLVIN-SYNTHASE-RXN","compounds":"(E)-cinnamoyl-CoA + 3 H(+) + 3 malonyl-CoA => (E)-pinosylvin + 4 CO2 + 4 CoA"}
{"X":15875,"RHEA_ID":12554,"compounds":"(E)-pinosylvin + 4 CO2 + 4 CoA => (E)-cinnamoyl-CoA + 3 H(+) + 3 malonyl-CoA"}
{"X":15876,"RHEA_ID":12556,"DIRECTION":"UN","MASTER_ID":12556,"ec":"3.1.1.31","compounds":"6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)"}
{"X":15877,"RHEA_ID":12557,"DIRECTION":"LR","MASTER_ID":12556,"ecocyc":"6PGLUCONOLACT-RXN","metacyc":"6PGLUCONOLACT-RXN","reactome":"R-HSA-71296.3","compounds":"6-phospho-D-glucono-1,5-lactone + H2O => 6-phospho-D-gluconate + H(+)"}
{"X":15878,"RHEA_ID":12558,"compounds":"6-phospho-D-gluconate + H(+) => 6-phospho-D-glucono-1,5-lactone + H2O"}
{"X":15879,"RHEA_ID":32978,"compounds":"1,2-diacyl-sn-glycero-3-phospho-L-serine + 2 H2O <=> 2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-L-serine"}
{"X":15880,"RHEA_ID":12560,"DIRECTION":"UN","MASTER_ID":12560,"ec":"2.4.1.218","compounds":"hydroquinone + UDP-alpha-D-glucose = H(+) + hydroquinone O-beta-D-glucopyranoside + UDP"}
{"X":15881,"RHEA_ID":12561,"compounds":"hydroquinone + UDP-alpha-D-glucose => H(+) + hydroquinone O-beta-D-glucopyranoside + UDP"}
{"X":15882,"RHEA_ID":12562,"compounds":"H(+) + hydroquinone O-beta-D-glucopyranoside + UDP => hydroquinone + UDP-alpha-D-glucose"}
{"X":15883,"RHEA_ID":32982,"compounds":"a 1-acyl-sn-glycero-3-phospho-L-serine + H2O <=> a fatty acid + H(+) + sn-glycero-3-phospho-L-serine"}
{"X":15884,"RHEA_ID":12564,"compounds":"1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + NAD(+) = 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H(+) + NADH"}
{"X":15885,"RHEA_ID":12565,"compounds":"1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + NAD(+) => 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H(+) + NADH"}
{"X":15886,"RHEA_ID":12566,"compounds":"1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H(+) + NADH => 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + NAD(+)"}
{"X":15887,"RHEA_ID":12568,"DIRECTION":"UN","MASTER_ID":12568,"ec":"1.14.13.29","compounds":"4-nitrophenol + H(+) + NADH + O2 = 4-nitrocatechol + H2O + NAD(+)"}
{"X":15888,"RHEA_ID":12569,"DIRECTION":"LR","MASTER_ID":12568,"metacyc":"4-NITROPHENOL-2-MONOOXYGENASE-RXN","compounds":"4-nitrophenol + H(+) + NADH + O2 => 4-nitrocatechol + H2O + NAD(+)"}
{"X":15889,"RHEA_ID":12570,"compounds":"4-nitrocatechol + H2O + NAD(+) => 4-nitrophenol + H(+) + NADH + O2"}
{"X":15890,"RHEA_ID":32990,"compounds":"a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> a carboxylate + H(+) + sn-glycero-3-phospho-1D-myo-inositol"}
{"X":15891,"RHEA_ID":12572,"DIRECTION":"UN","MASTER_ID":12572,"ec":"6.3.1.10","compounds":"(R)-1-aminopropan-2-ol + adenosylcob(III)yrate + ATP = adenosylcob(III)inamide + ADP + H(+) + phosphate"}
{"X":15892,"RHEA_ID":12573,"DIRECTION":"LR","MASTER_ID":12572,"metacyc":"6.3.1.10-RXN","compounds":"(R)-1-aminopropan-2-ol + adenosylcob(III)yrate + ATP => adenosylcob(III)inamide + ADP + H(+) + phosphate"}
{"X":15893,"RHEA_ID":12574,"compounds":"adenosylcob(III)inamide + ADP + H(+) + phosphate => (R)-1-aminopropan-2-ol + adenosylcob(III)yrate + ATP"}
{"X":15894,"RHEA_ID":22403,"DIRECTION":"BI","MASTER_ID":22400,"metacyc":"1.1.1.53-RXN","compounds":"androstan-3alpha,17beta-diol + NAD(+) <=> 17beta-hydroxyandrostanone + H(+) + NADH"}
{"X":15895,"RHEA_ID":12576,"DIRECTION":"UN","MASTER_ID":12576,"ec":"2.4.1.66","compounds":"(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[procollagen] + UDP-alpha-D-glucose = (5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[procollagen] + H(+) + UDP"}
{"X":15896,"RHEA_ID":12577,"DIRECTION":"LR","MASTER_ID":12576,"metacyc":"PROCOLLAGEN-GLUCOSYLTRANSFERASE-RXN","compounds":"(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[procollagen] + UDP-alpha-D-glucose => (5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[procollagen] + H(+) + UDP"}
{"X":15897,"RHEA_ID":12578,"compounds":"(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[procollagen] + H(+) + UDP => (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[procollagen] + UDP-alpha-D-glucose"}
{"X":15898,"RHEA_ID":32998,"compounds":"a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":15899,"RHEA_ID":12580,"DIRECTION":"UN","MASTER_ID":12580,"ec":"1.5.1.23","compounds":"H2O + NAD(+) + tauropine = H(+) + NADH + pyruvate + taurine"}
{"X":15900,"RHEA_ID":12581,"compounds":"H2O + NAD(+) + tauropine => H(+) + NADH + pyruvate + taurine"}
{"X":15901,"RHEA_ID":12582,"DIRECTION":"RL","MASTER_ID":12580,"metacyc":"TAUROPINE-DEHYDROGENASE-RXN","compounds":"H(+) + NADH + pyruvate + taurine => H2O + NAD(+) + tauropine"}
{"X":15902,"RHEA_ID":52947,"compounds":"cholate + UDP-alpha-D-glucuronate <=> choloyl-24-O-(beta-D-glucuronate) + UDP"}
{"X":15903,"RHEA_ID":12584,"DIRECTION":"UN","MASTER_ID":12584,"ec":"4.2.1.98","metacyc":"4.2.1.98-RXN","compounds":"16alpha-hydroxyprogesterone = 16,17-didehydroprogesterone + H2O"}
{"X":15904,"RHEA_ID":12585,"compounds":"16alpha-hydroxyprogesterone => 16,17-didehydroprogesterone + H2O"}
{"X":15905,"RHEA_ID":12586,"compounds":"16,17-didehydroprogesterone + H2O => 16alpha-hydroxyprogesterone"}
{"X":15906,"RHEA_ID":12588,"DIRECTION":"UN","MASTER_ID":12588,"ec":"2.4.1.92","compounds":"ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = ganglioside GM2 (d18:1(4E)) + H(+) + UDP"}
{"X":15907,"RHEA_ID":12589,"DIRECTION":"LR","MASTER_ID":12588,"metacyc":"2.4.1.92-RXN","compounds":"ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => ganglioside GM2 (d18:1(4E)) + H(+) + UDP"}
{"X":15908,"RHEA_ID":12590,"compounds":"ganglioside GM2 (d18:1(4E)) + H(+) + UDP => ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine"}
{"X":15909,"RHEA_ID":42963,"compounds":"H(+) + NAD(+) + 2 reduced [nitric oxide reductase rubredoxin domain] <=> NADH + 2 oxidized [nitric oxide reductase rubredoxin domain]"}
{"X":15910,"RHEA_ID":12593,"DIRECTION":"UN","MASTER_ID":12593,"ec":"2.7.8.5","compounds":"a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)"}
{"X":15911,"RHEA_ID":12594,"compounds":"a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)"}
{"X":15912,"RHEA_ID":12595,"compounds":"1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+) => a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate"}
{"X":15913,"RHEA_ID":42967,"compounds":"uridine(54/55) in tRNA <=> pseudouridine(54/55) in tRNA"}
{"X":15914,"RHEA_ID":12597,"DIRECTION":"UN","MASTER_ID":12597,"ec":"2.3.1.183","compounds":"acetyl-CoA + phosphinothricin = CoA + H(+) + N-acetylphosphinothricin"}
{"X":15915,"RHEA_ID":12598,"compounds":"acetyl-CoA + phosphinothricin => CoA + H(+) + N-acetylphosphinothricin"}
{"X":15916,"RHEA_ID":12599,"compounds":"CoA + H(+) + N-acetylphosphinothricin => acetyl-CoA + phosphinothricin"}
{"X":15917,"RHEA_ID":12601,"DIRECTION":"UN","MASTER_ID":12601,"ec":"2.6.1.39","compounds":"2-oxoglutarate + L-2-aminoadipate = 2-oxoadipate + L-glutamate"}
{"X":15918,"RHEA_ID":12602,"DIRECTION":"LR","MASTER_ID":12601,"reactome":"R-HSA-70952.3","compounds":"2-oxoglutarate + L-2-aminoadipate => 2-oxoadipate + L-glutamate"}
{"X":15919,"RHEA_ID":12603,"DIRECTION":"RL","MASTER_ID":12601,"reactome":"R-HSA-508561.3","compounds":"2-oxoadipate + L-glutamate => 2-oxoglutarate + L-2-aminoadipate"}
{"X":15920,"RHEA_ID":42975,"compounds":"1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a cardiolipin + ethanolamine"}
{"X":15921,"RHEA_ID":12605,"DIRECTION":"UN","MASTER_ID":12605,"ec":"2.2.1.7","compounds":"D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2"}
{"X":15922,"RHEA_ID":12606,"DIRECTION":"LR","MASTER_ID":12605,"ecocyc":"DXS-RXN","metacyc":"DXS-RXN","compounds":"D-glyceraldehyde 3-phosphate + H(+) + pyruvate => 1-deoxy-D-xylulose 5-phosphate + CO2"}
{"X":15923,"RHEA_ID":12607,"compounds":"1-deoxy-D-xylulose 5-phosphate + CO2 => D-glyceraldehyde 3-phosphate + H(+) + pyruvate"}
{"X":15924,"RHEA_ID":12609,"DIRECTION":"UN","MASTER_ID":12609,"ec":"2.1.1.67","compounds":"mercaptopurine + S-adenosyl-L-methionine = 6-methylthiopurine + H(+) + S-adenosyl-L-homocysteine"}
{"X":15925,"RHEA_ID":12610,"compounds":"mercaptopurine + S-adenosyl-L-methionine => 6-methylthiopurine + H(+) + S-adenosyl-L-homocysteine"}
{"X":15926,"RHEA_ID":12611,"compounds":"6-methylthiopurine + H(+) + S-adenosyl-L-homocysteine => mercaptopurine + S-adenosyl-L-methionine"}
{"X":15927,"RHEA_ID":33028,"DIRECTION":"LR","MASTER_ID":33027,"metacyc":"RXN-10670","compounds":"4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spheroidene => 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + spheroiden-2-one"}
{"X":15928,"RHEA_ID":12613,"DIRECTION":"UN","MASTER_ID":12613,"ec":"1.8.4.4","compounds":"2 glutathione + L-cystine = glutathione disulfide + 2 L-cysteine"}
{"X":15929,"RHEA_ID":12614,"DIRECTION":"LR","MASTER_ID":12613,"metacyc":"1.8.4.4-RXN","compounds":"2 glutathione + L-cystine => glutathione disulfide + 2 L-cysteine"}
{"X":15930,"RHEA_ID":12615,"compounds":"glutathione disulfide + 2 L-cysteine => 2 glutathione + L-cystine"}
{"X":15931,"RHEA_ID":33032,"compounds":"D-fructose + H(+) + NADH => D-sorbitol + NAD(+)"}
{"X":15932,"RHEA_ID":12617,"DIRECTION":"UN","MASTER_ID":12617,"ec":"2.7.1.157","compounds":"ATP + N-acetyl-alpha-D-galactosamine = ADP + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate"}
{"X":15933,"RHEA_ID":12618,"compounds":"ATP + N-acetyl-alpha-D-galactosamine => ADP + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate"}
{"X":15934,"RHEA_ID":12619,"compounds":"ADP + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate => ATP + N-acetyl-alpha-D-galactosamine"}
{"X":15935,"RHEA_ID":22446,"DIRECTION":"RL","MASTER_ID":22444,"metacyc":"RXN-11654","compounds":"(E)-coniferaldehyde + H(+) + NADPH => (E)-coniferol + NADP(+)"}
{"X":15936,"RHEA_ID":12621,"DIRECTION":"UN","MASTER_ID":12621,"ec":"4.1.1.12","compounds":"H(+) + L-aspartate = CO2 + L-alanine"}
{"X":15937,"RHEA_ID":12622,"compounds":"H(+) + L-aspartate => CO2 + L-alanine"}
{"X":15938,"RHEA_ID":12623,"compounds":"CO2 + L-alanine => H(+) + L-aspartate"}
{"X":15939,"RHEA_ID":12625,"DIRECTION":"UN","MASTER_ID":12625,"ec":"2.3.1.92","compounds":"(S)-malate + 1-O-(trans-sinapoyl)-beta-D-glucose = D-glucose + sinapoyl (S)-malate"}
{"X":15940,"RHEA_ID":12626,"DIRECTION":"LR","MASTER_ID":12625,"metacyc":"2.3.1.92-RXN","compounds":"(S)-malate + 1-O-(trans-sinapoyl)-beta-D-glucose => D-glucose + sinapoyl (S)-malate"}
{"X":15941,"RHEA_ID":12627,"compounds":"D-glucose + sinapoyl (S)-malate => (S)-malate + 1-O-(trans-sinapoyl)-beta-D-glucose"}
{"X":15942,"RHEA_ID":22453,"compounds":"[phosphate](n+1) + n H2O => n H(+) + (n+1) phosphate"}
{"X":15943,"RHEA_ID":12629,"DIRECTION":"UN","MASTER_ID":12629,"ec":"1.14.11.11","compounds":"2-oxoglutarate + L-hyoscyamine + O2 = (6S)-6-hydroxyhyoscyamine + CO2 + succinate"}
{"X":15944,"RHEA_ID":12630,"DIRECTION":"LR","MASTER_ID":12629,"metacyc":"HYOSCYAMINE-6-DIOXYGENASE-RXN","compounds":"2-oxoglutarate + L-hyoscyamine + O2 => (6S)-6-hydroxyhyoscyamine + CO2 + succinate"}
{"X":15945,"RHEA_ID":12631,"compounds":"(6S)-6-hydroxyhyoscyamine + CO2 + succinate => 2-oxoglutarate + L-hyoscyamine + O2"}
{"X":15946,"RHEA_ID":22457,"DIRECTION":"LR","MASTER_ID":22456,"macie":"M0096","metacyc":"CREATINASE-RXN","compounds":"creatine + H2O => sarcosine + urea"}
{"X":15947,"RHEA_ID":12633,"DIRECTION":"UN","MASTER_ID":12633,"ec":"1.14.12.10","compounds":"benzoate + H(+) + NADH + O2 = (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+)"}
{"X":15948,"RHEA_ID":12634,"DIRECTION":"LR","MASTER_ID":12633,"metacyc":"BENZOATE-12-DIOXYGENASE-RXN","compounds":"benzoate + H(+) + NADH + O2 => (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+)"}
{"X":15949,"RHEA_ID":12635,"compounds":"(1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+) => benzoate + H(+) + NADH + O2"}
{"X":15950,"RHEA_ID":22461,"compounds":"a 2,3-saturated acyl-CoA + NADP(+) => a 2,3-dehydroacyl-CoA + H(+) + NADPH"}
{"X":15951,"RHEA_ID":12637,"DIRECTION":"UN","MASTER_ID":12637,"ec":"2.4.1.50","compounds":"(5R)-5-hydroxy-L-lysyl-[procollagen] + UDP-alpha-D-galactose = (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[procollagen] + H(+) + UDP"}
{"X":15952,"RHEA_ID":12638,"compounds":"(5R)-5-hydroxy-L-lysyl-[procollagen] + UDP-alpha-D-galactose => (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[procollagen] + H(+) + UDP"}
{"X":15953,"RHEA_ID":12639,"compounds":"(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[procollagen] + H(+) + UDP => (5R)-5-hydroxy-L-lysyl-[procollagen] + UDP-alpha-D-galactose"}
{"X":15954,"RHEA_ID":22465,"DIRECTION":"LR","MASTER_ID":22464,"metacyc":"TYROSINE-N-MONOOXYGENASE-RXN","compounds":"L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase]"}
{"X":15955,"RHEA_ID":12641,"DIRECTION":"UN","MASTER_ID":12641,"ec":"1.1.1.95","compounds":"(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + H(+) + NADH"}
{"X":15956,"RHEA_ID":12642,"DIRECTION":"LR","MASTER_ID":12641,"reactome":"R-HSA-977348.2","compounds":"(2R)-3-phosphoglycerate + NAD(+) => 3-phosphooxypyruvate + H(+) + NADH"}
{"X":15957,"RHEA_ID":12643,"compounds":"3-phosphooxypyruvate + H(+) + NADH => (2R)-3-phosphoglycerate + NAD(+)"}
{"X":15958,"RHEA_ID":22469,"DIRECTION":"LR","MASTER_ID":22468,"metacyc":"RXN-10055","compounds":"GTP + 3 H2O => 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 H(+) + 2 phosphate"}
{"X":15959,"RHEA_ID":12645,"DIRECTION":"UN","MASTER_ID":12645,"ec":"1.2.7.8","compounds":"CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] + S-2-(indol-3-yl)acetyl-CoA"}
{"X":15960,"RHEA_ID":12646,"compounds":"CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] => CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] + S-2-(indol-3-yl)acetyl-CoA"}
{"X":15961,"RHEA_ID":12647,"compounds":"CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] + S-2-(indol-3-yl)acetyl-CoA => CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":15962,"RHEA_ID":22473,"DIRECTION":"LR","MASTER_ID":22472,"metacyc":"PANTETHEINE-KINASE-RXN","compounds":"(R)-pantetheine + ATP => ADP + D-pantetheine 4'-phosphate + H(+)"}
{"X":15963,"RHEA_ID":12649,"DIRECTION":"UN","MASTER_ID":12649,"ec":"1.1.1.173","compounds":"L-rhamnofuranose + NAD(+) = H(+) + L-rhamnono-1,4-lactone + NADH"}
{"X":15964,"RHEA_ID":12649,"DIRECTION":"UN","MASTER_ID":12649,"ec":"1.1.1.378","compounds":"L-rhamnofuranose + NAD(+) = H(+) + L-rhamnono-1,4-lactone + NADH"}
{"X":15965,"RHEA_ID":12650,"DIRECTION":"LR","MASTER_ID":12649,"metacyc":"RXN-12158","compounds":"L-rhamnofuranose + NAD(+) => H(+) + L-rhamnono-1,4-lactone + NADH"}
{"X":15966,"RHEA_ID":12651,"compounds":"H(+) + L-rhamnono-1,4-lactone + NADH => L-rhamnofuranose + NAD(+)"}
{"X":15967,"RHEA_ID":22478,"compounds":"4-nitroquinoline N-oxide + 2 H(+) + 2 NADPH => 4-(hydroxyamino)quinoline N-oxide + H2O + 2 NADP(+)"}
{"X":15968,"RHEA_ID":12653,"DIRECTION":"UN","MASTER_ID":12653,"ec":"1.1.1.38","compounds":"(S)-malate + NAD(+) = CO2 + NADH + pyruvate"}
{"X":15969,"RHEA_ID":12653,"DIRECTION":"UN","MASTER_ID":12653,"ec":"1.1.1.39","compounds":"(S)-malate + NAD(+) = CO2 + NADH + pyruvate"}
{"X":15970,"RHEA_ID":12654,"DIRECTION":"LR","MASTER_ID":12653,"ecocyc":"1.1.1.39-RXN","metacyc":"1.1.1.39-RXN","reactome":"R-HSA-9012268.2","compounds":"(S)-malate + NAD(+) => CO2 + NADH + pyruvate"}
{"X":15971,"RHEA_ID":12654,"DIRECTION":"LR","MASTER_ID":12653,"ecocyc":"MALIC-NAD-RXN","metacyc":"1.1.1.39-RXN","reactome":"R-HSA-9012268.2","compounds":"(S)-malate + NAD(+) => CO2 + NADH + pyruvate"}
{"X":15972,"RHEA_ID":12654,"DIRECTION":"LR","MASTER_ID":12653,"ecocyc":"MALIC-NAD-RXN","metacyc":"MALIC-NAD-RXN","reactome":"R-HSA-9012268.2","compounds":"(S)-malate + NAD(+) => CO2 + NADH + pyruvate"}
{"X":15973,"RHEA_ID":12654,"DIRECTION":"LR","MASTER_ID":12653,"ecocyc":"1.1.1.39-RXN","metacyc":"MALIC-NAD-RXN","reactome":"R-HSA-9012268.2","compounds":"(S)-malate + NAD(+) => CO2 + NADH + pyruvate"}
{"X":15974,"RHEA_ID":12655,"compounds":"CO2 + NADH + pyruvate => (S)-malate + NAD(+)"}
{"X":15975,"RHEA_ID":22486,"compounds":"GMP + GTP + 2 H(+) => H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate"}
{"X":15976,"RHEA_ID":12657,"DIRECTION":"UN","MASTER_ID":12657,"ec":"5.1.99.4","compounds":"(2S)-2-methylacyl-CoA = (2R)-2-methylacyl-CoA"}
{"X":15977,"RHEA_ID":12658,"compounds":"(2S)-2-methylacyl-CoA => (2R)-2-methylacyl-CoA"}
{"X":15978,"RHEA_ID":12659,"compounds":"(2R)-2-methylacyl-CoA => (2S)-2-methylacyl-CoA"}
{"X":15979,"RHEA_ID":12661,"DIRECTION":"UN","MASTER_ID":12661,"ec":"2.3.1.21","compounds":"(R)-carnitine + hexadecanoyl-CoA = CoA + O-hexadecanoyl-(R)-carnitine"}
{"X":15980,"RHEA_ID":12662,"compounds":"(R)-carnitine + hexadecanoyl-CoA => CoA + O-hexadecanoyl-(R)-carnitine"}
{"X":15981,"RHEA_ID":12663,"compounds":"CoA + O-hexadecanoyl-(R)-carnitine => (R)-carnitine + hexadecanoyl-CoA"}
{"X":15982,"RHEA_ID":22494,"compounds":"formamide + L-glutamate => H2O + N-formimidoyl-L-glutamate"}
{"X":15983,"RHEA_ID":12665,"DIRECTION":"UN","MASTER_ID":12665,"ec":"2.3.1.81","compounds":"a 2-deoxystreptamine antibiotic + acetyl-CoA = an N(3')-acetyl-2-deoxystreptamine antibiotic + CoA + H(+)"}
{"X":15984,"RHEA_ID":12666,"compounds":"a 2-deoxystreptamine antibiotic + acetyl-CoA => an N(3')-acetyl-2-deoxystreptamine antibiotic + CoA + H(+)"}
{"X":15985,"RHEA_ID":12667,"compounds":"an N(3')-acetyl-2-deoxystreptamine antibiotic + CoA + H(+) => a 2-deoxystreptamine antibiotic + acetyl-CoA"}
{"X":15986,"RHEA_ID":22502,"compounds":"(E)-feruloylacetyl-CoA + CO2 + CoA => (E)-feruloyl-CoA + H(+) + malonyl-CoA"}
{"X":15987,"RHEA_ID":12669,"DIRECTION":"UN","MASTER_ID":12669,"ec":"3.1.3.43","compounds":"[pyruvate dehydrogenase E1 alpha subunit]-O-phospho-L-serine + H2O = [pyruvate dehydrogenase E1 alpha subunit]-L-serine + phosphate"}
{"X":15988,"RHEA_ID":12670,"DIRECTION":"LR","MASTER_ID":12669,"metacyc":"3.1.3.43-RXN","compounds":"[pyruvate dehydrogenase E1 alpha subunit]-O-phospho-L-serine + H2O => [pyruvate dehydrogenase E1 alpha subunit]-L-serine + phosphate"}
{"X":15989,"RHEA_ID":12671,"compounds":"[pyruvate dehydrogenase E1 alpha subunit]-L-serine + phosphate => [pyruvate dehydrogenase E1 alpha subunit]-O-phospho-L-serine + H2O"}
{"X":15990,"RHEA_ID":12673,"DIRECTION":"UN","MASTER_ID":12673,"ec":"4.2.1.84","compounds":"an aliphatic amide = a nitrile + H2O"}
{"X":15991,"RHEA_ID":12674,"compounds":"an aliphatic amide => a nitrile + H2O"}
{"X":15992,"RHEA_ID":12675,"DIRECTION":"RL","MASTER_ID":12673,"macie":"M0057","compounds":"a nitrile + H2O => an aliphatic amide"}
{"X":15993,"RHEA_ID":12677,"DIRECTION":"UN","MASTER_ID":12677,"ec":"1.14.99.21","compounds":"AH2 + Latia luciferin + 2 O2 = A + CO2 + formate + H(+) + H2O + hnu + oxidized Latia luciferin"}
{"X":15994,"RHEA_ID":12678,"DIRECTION":"LR","MASTER_ID":12677,"metacyc":"1.14.99.21-RXN","compounds":"AH2 + Latia luciferin + 2 O2 => A + CO2 + formate + H(+) + H2O + hnu + oxidized Latia luciferin"}
{"X":15995,"RHEA_ID":12679,"compounds":"A + CO2 + formate + H(+) + H2O + hnu + oxidized Latia luciferin => AH2 + Latia luciferin + 2 O2"}
{"X":15996,"RHEA_ID":12681,"DIRECTION":"UN","MASTER_ID":12681,"ec":"3.5.4.21","compounds":"creatinine + H(+) + H2O = N-methylhydantoin + NH4(+)"}
{"X":15997,"RHEA_ID":12682,"DIRECTION":"LR","MASTER_ID":12681,"metacyc":"CREATININE-DEAMINASE-RXN","compounds":"creatinine + H(+) + H2O => N-methylhydantoin + NH4(+)"}
{"X":15998,"RHEA_ID":12683,"compounds":"N-methylhydantoin + NH4(+) => creatinine + H(+) + H2O"}
{"X":15999,"RHEA_ID":22514,"compounds":"hydrogenobyrinate => 3 H(+) + precorrin-8X"}
{"X":16000,"RHEA_ID":12685,"DIRECTION":"UN","MASTER_ID":12685,"ec":"1.8.1.15","compounds":"2 mycothiol + NADP(+) = H(+) + mycothione + NADPH"}
{"X":16001,"RHEA_ID":12686,"compounds":"2 mycothiol + NADP(+) => H(+) + mycothione + NADPH"}
{"X":16002,"RHEA_ID":12687,"DIRECTION":"RL","MASTER_ID":12685,"metacyc":"1.8.1.15-RXN","compounds":"H(+) + mycothione + NADPH => 2 mycothiol + NADP(+)"}
{"X":16003,"RHEA_ID":22518,"compounds":"ADP + H(+) + N-phosphotaurocyamine => ATP + taurocyamine"}
{"X":16004,"RHEA_ID":12689,"DIRECTION":"UN","MASTER_ID":12689,"ec":"1.8.1.15","compounds":"2 mycothiol + NAD(+) = H(+) + mycothione + NADH"}
{"X":16005,"RHEA_ID":12690,"compounds":"2 mycothiol + NAD(+) => H(+) + mycothione + NADH"}
{"X":16006,"RHEA_ID":12691,"DIRECTION":"RL","MASTER_ID":12689,"metacyc":"1.8.1.15-RXN","compounds":"H(+) + mycothione + NADH => 2 mycothiol + NAD(+)"}
{"X":16007,"RHEA_ID":22522,"compounds":"all-trans-retinoate + H(+) + H2O2 => all-trans-retinal + H2O + O2"}
{"X":16008,"RHEA_ID":12693,"DIRECTION":"UN","MASTER_ID":12693,"ec":"2.5.1.52","compounds":"3,4-dihydroxypyridine + O-acetyl-L-serine = 3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate + H(+)"}
{"X":16009,"RHEA_ID":12694,"DIRECTION":"LR","MASTER_ID":12693,"metacyc":"RXN-7461","compounds":"3,4-dihydroxypyridine + O-acetyl-L-serine => 3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate + H(+)"}
{"X":16010,"RHEA_ID":12695,"compounds":"3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate + H(+) => 3,4-dihydroxypyridine + O-acetyl-L-serine"}
{"X":16011,"RHEA_ID":22526,"compounds":"a carotenoid phi-end derivative + 2 AH2 => 2 A + a carotenoid beta-end derivative"}
{"X":16012,"RHEA_ID":12697,"DIRECTION":"UN","MASTER_ID":12697,"ec":"2.7.4.12","compounds":"ATP + dGMP = ADP + dGDP"}
{"X":16013,"RHEA_ID":12698,"DIRECTION":"LR","MASTER_ID":12697,"ecocyc":"GMKALT-RXN","metacyc":"GMKALT-RXN","compounds":"ATP + dGMP => ADP + dGDP"}
{"X":16014,"RHEA_ID":12699,"compounds":"ADP + dGDP => ATP + dGMP"}
{"X":16015,"RHEA_ID":22530,"compounds":"a flavonol 3-O-[alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + H(+) + UDP => a flavonol 3-O-beta-D-glucoside + UDP-beta-L-rhamnose"}
{"X":16016,"RHEA_ID":12701,"DIRECTION":"UN","MASTER_ID":12701,"ec":"1.17.4.2","compounds":"[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-triphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-triphosphate"}
{"X":16017,"RHEA_ID":12702,"compounds":"[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-triphosphate + H2O => [thioredoxin]-dithiol + a ribonucleoside 5'-triphosphate"}
{"X":16018,"RHEA_ID":12703,"compounds":"[thioredoxin]-dithiol + a ribonucleoside 5'-triphosphate => [thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-triphosphate + H2O"}
{"X":16019,"RHEA_ID":12705,"DIRECTION":"UN","MASTER_ID":12705,"ec":"2.1.1.77","compounds":"[protein]-L-beta-isoaspartate + S-adenosyl-L-methionine = [protein]-L-beta-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine"}
{"X":16020,"RHEA_ID":12706,"DIRECTION":"LR","MASTER_ID":12705,"ecocyc":"2.1.1.77-RXN","metacyc":"2.1.1.77-RXN","compounds":"[protein]-L-beta-isoaspartate + S-adenosyl-L-methionine => [protein]-L-beta-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine"}
{"X":16021,"RHEA_ID":12707,"compounds":"[protein]-L-beta-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine => [protein]-L-beta-isoaspartate + S-adenosyl-L-methionine"}
{"X":16022,"RHEA_ID":22538,"compounds":"H(+) + S-adenosyl-L-homocysteine + tetrahydropalmatine => (S)-tetrahydrocolumbamine + S-adenosyl-L-methionine"}
{"X":16023,"RHEA_ID":12709,"DIRECTION":"UN","MASTER_ID":12709,"ec":"2.7.1.137","compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)"}
{"X":16024,"RHEA_ID":12710,"DIRECTION":"LR","MASTER_ID":12709,"metacyc":"1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN","compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)"}
{"X":16025,"RHEA_ID":12711,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP"}
{"X":16026,"RHEA_ID":22542,"compounds":"9-riburonosyladenine + H(+) + H2O2 => 5'-dehydroadenosine + H2O + O2"}
{"X":16027,"RHEA_ID":12713,"DIRECTION":"UN","MASTER_ID":12713,"ec":"2.7.6.4","metacyc":"NUCLEOTIDE-PYROPHOSPHOKINASE-RXN","compounds":"a nucleoside 5'-phosphate + ATP = a 5'-phosphonucleoside 3'-diphosphate + AMP + H(+)"}
{"X":16028,"RHEA_ID":12714,"compounds":"a nucleoside 5'-phosphate + ATP => a 5'-phosphonucleoside 3'-diphosphate + AMP + H(+)"}
{"X":16029,"RHEA_ID":12715,"compounds":"a 5'-phosphonucleoside 3'-diphosphate + AMP + H(+) => a nucleoside 5'-phosphate + ATP"}
{"X":16030,"RHEA_ID":22546,"compounds":"a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O"}
{"X":16031,"RHEA_ID":12717,"DIRECTION":"UN","MASTER_ID":12717,"ec":"2.7.1.140","compounds":"1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)"}
{"X":16032,"RHEA_ID":12718,"DIRECTION":"LR","MASTER_ID":12717,"metacyc":"2.7.1.140-RXN","reactome":"R-HSA-1855228.2","compounds":"1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)"}
{"X":16033,"RHEA_ID":12719,"compounds":"1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+) => 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP"}
{"X":16034,"RHEA_ID":22550,"compounds":"(S)-2-amino-6-oxohexanoate + H2O2 + NH4(+) => H2O + L-lysine + O2"}
{"X":16035,"RHEA_ID":12721,"DIRECTION":"UN","MASTER_ID":12721,"ec":"2.5.1.16","compounds":"putrescine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + S-methyl-5'-thioadenosine + spermidine"}
{"X":16036,"RHEA_ID":12722,"DIRECTION":"LR","MASTER_ID":12721,"ecocyc":"SPERMIDINESYN-RXN","reactome":"R-HSA-351215.1","compounds":"putrescine + S-adenosyl 3-(methylsulfanyl)propylamine => H(+) + S-methyl-5'-thioadenosine + spermidine"}
{"X":16037,"RHEA_ID":12723,"compounds":"H(+) + S-methyl-5'-thioadenosine + spermidine => putrescine + S-adenosyl 3-(methylsulfanyl)propylamine"}
{"X":16038,"RHEA_ID":22554,"compounds":"adenosine 3',5'-bisphosphate + an alkyl sulfate + H(+) => 3'-phosphoadenylyl sulfate + an alcohol"}
{"X":16039,"RHEA_ID":12725,"DIRECTION":"UN","MASTER_ID":12725,"ec":"1.1.1.15","metacyc":"D-IDITOL-2-DEHYDROGENASE-RXN","compounds":"D-iditol + NAD(+) = H(+) + keto-D-sorbose + NADH"}
{"X":16040,"RHEA_ID":12726,"compounds":"D-iditol + NAD(+) => H(+) + keto-D-sorbose + NADH"}
{"X":16041,"RHEA_ID":12727,"compounds":"H(+) + keto-D-sorbose + NADH => D-iditol + NAD(+)"}
{"X":16042,"RHEA_ID":22558,"compounds":"AH2 + oxaloacetate => (S)-malate + A"}
{"X":16043,"RHEA_ID":12729,"DIRECTION":"UN","MASTER_ID":12729,"ec":"5.3.3.22","compounds":"lutein = (3R,3'S)-zeaxanthin"}
{"X":16044,"RHEA_ID":12730,"compounds":"lutein => (3R,3'S)-zeaxanthin"}
{"X":16045,"RHEA_ID":12731,"compounds":"(3R,3'S)-zeaxanthin => lutein"}
{"X":16046,"RHEA_ID":22562,"DIRECTION":"RL","MASTER_ID":22560,"metacyc":"RXN-3562","compounds":"2'-hydroxyformononetin + 2 H(+) + NADPH => (3R)-vestitone + NADP(+)"}
{"X":16047,"RHEA_ID":12733,"DIRECTION":"UN","MASTER_ID":12733,"ec":"2.4.2.19","compounds":"CO2 + diphosphate + nicotinate beta-D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate"}
{"X":16048,"RHEA_ID":12734,"compounds":"CO2 + diphosphate + nicotinate beta-D-ribonucleotide => 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate"}
{"X":16049,"RHEA_ID":12735,"DIRECTION":"RL","MASTER_ID":12733,"ecocyc":"QUINOPRIBOTRANS-RXN","macie":"M0008","metacyc":"QUINOPRIBOTRANS-RXN","reactome":"R-HSA-197268.3","compounds":"5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate => CO2 + diphosphate + nicotinate beta-D-ribonucleotide"}
{"X":16050,"RHEA_ID":22564,"DIRECTION":"UN","MASTER_ID":22564,"ec":"1.3.1.104","compounds":"a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + H(+) + NADPH"}
{"X":16051,"RHEA_ID":12737,"DIRECTION":"UN","MASTER_ID":12737,"ec":"1.21.4.1","compounds":"5-aminopentanoate + [PrdC protein]-Se-L-selenocysteinyl-S-L-cysteine = [PrdC protein]-L-selenocysteine/L-cysteine + D-proline"}
{"X":16052,"RHEA_ID":12738,"compounds":"5-aminopentanoate + [PrdC protein]-Se-L-selenocysteinyl-S-L-cysteine => [PrdC protein]-L-selenocysteine/L-cysteine + D-proline"}
{"X":16053,"RHEA_ID":12739,"DIRECTION":"RL","MASTER_ID":12737,"metacyc":"1.21.4.1-RXN","compounds":"[PrdC protein]-L-selenocysteine/L-cysteine + D-proline => 5-aminopentanoate + [PrdC protein]-Se-L-selenocysteinyl-S-L-cysteine"}
{"X":16054,"RHEA_ID":22568,"DIRECTION":"UN","MASTER_ID":22568,"ec":"5.3.2.7","compounds":"ascopyrone M = ascopyrone P"}
{"X":16055,"RHEA_ID":12741,"DIRECTION":"UN","MASTER_ID":12741,"ec":"3.5.4.7","metacyc":"ADP-DEAMINASE-RXN","compounds":"ADP + H(+) + H2O = IDP + NH4(+)"}
{"X":16056,"RHEA_ID":12741,"DIRECTION":"UN","MASTER_ID":12741,"ec":"3.5.4.17","metacyc":"ADP-DEAMINASE-RXN","compounds":"ADP + H(+) + H2O = IDP + NH4(+)"}
{"X":16057,"RHEA_ID":12742,"compounds":"ADP + H(+) + H2O => IDP + NH4(+)"}
{"X":16058,"RHEA_ID":12743,"compounds":"IDP + NH4(+) => ADP + H(+) + H2O"}
{"X":16059,"RHEA_ID":22573,"DIRECTION":"LR","MASTER_ID":22572,"metacyc":"METHYLGUTAMATE-DEHYDROGENASE-RXN","compounds":"A + H2O + N-methyl-L-glutamate => AH2 + formaldehyde + L-glutamate"}
{"X":16060,"RHEA_ID":12745,"DIRECTION":"UN","MASTER_ID":12745,"ec":"3.1.1.25","compounds":"a 1,4-lactone + H2O = a 4-hydroxyacid + H(+)"}
{"X":16061,"RHEA_ID":12746,"DIRECTION":"LR","MASTER_ID":12745,"metacyc":"14-LACTONASE-RXN","compounds":"a 1,4-lactone + H2O => a 4-hydroxyacid + H(+)"}
{"X":16062,"RHEA_ID":12747,"compounds":"a 4-hydroxyacid + H(+) => a 1,4-lactone + H2O"}
{"X":16063,"RHEA_ID":12749,"DIRECTION":"UN","MASTER_ID":12749,"ec":"4.1.1.59","compounds":"3,4,5-trihydroxybenzoate + H(+) = 1,2,3-trihydroxybenzene + CO2"}
{"X":16064,"RHEA_ID":12750,"compounds":"3,4,5-trihydroxybenzoate + H(+) => 1,2,3-trihydroxybenzene + CO2"}
{"X":16065,"RHEA_ID":12751,"compounds":"1,2,3-trihydroxybenzene + CO2 => 3,4,5-trihydroxybenzoate + H(+)"}
{"X":16066,"RHEA_ID":22581,"compounds":"(S)-4-hydroxy-2-oxopentanoate => (2Z)-2-hydroxypenta-2,4-dienoate + H2O"}
{"X":16067,"RHEA_ID":12753,"DIRECTION":"UN","MASTER_ID":12753,"ec":"1.1.1.156","compounds":"glycerol + NADP(+) = dihydroxyacetone + H(+) + NADPH"}
{"X":16068,"RHEA_ID":12754,"compounds":"glycerol + NADP(+) => dihydroxyacetone + H(+) + NADPH"}
{"X":16069,"RHEA_ID":12755,"compounds":"dihydroxyacetone + H(+) + NADPH => glycerol + NADP(+)"}
{"X":16070,"RHEA_ID":12757,"DIRECTION":"UN","MASTER_ID":12757,"ec":"1.3.1.69","metacyc":"ZEATIN-REDUCTASE-RXN","compounds":"dihydrozeatin + NADP(+) = H(+) + NADPH + zeatin"}
{"X":16071,"RHEA_ID":12758,"compounds":"dihydrozeatin + NADP(+) => H(+) + NADPH + zeatin"}
{"X":16072,"RHEA_ID":12759,"compounds":"H(+) + NADPH + zeatin => dihydrozeatin + NADP(+)"}
{"X":16073,"RHEA_ID":22589,"compounds":"4-aminobutanal => 1-pyrroline + H2O"}
{"X":16074,"RHEA_ID":12761,"DIRECTION":"UN","MASTER_ID":12761,"ec":"2.1.1.131","compounds":"precorrin-3B + S-adenosyl-L-methionine = 3 H(+) + precorrin-4 + S-adenosyl-L-homocysteine"}
{"X":16075,"RHEA_ID":12762,"compounds":"precorrin-3B + S-adenosyl-L-methionine => 3 H(+) + precorrin-4 + S-adenosyl-L-homocysteine"}
{"X":16076,"RHEA_ID":12763,"compounds":"3 H(+) + precorrin-4 + S-adenosyl-L-homocysteine => precorrin-3B + S-adenosyl-L-methionine"}
{"X":16077,"RHEA_ID":22593,"DIRECTION":"LR","MASTER_ID":22592,"metacyc":"ALLENE-OXIDE-CYCLASE-RXN","compounds":"(9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate => (10Z,15Z)-12-oxophytodienoate"}
{"X":16078,"RHEA_ID":12765,"DIRECTION":"UN","MASTER_ID":12765,"ec":"1.2.7.1","compounds":"CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate = acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":16079,"RHEA_ID":12766,"compounds":"CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate => acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":16080,"RHEA_ID":12767,"compounds":"acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate"}
{"X":16081,"RHEA_ID":22597,"compounds":"cephalosporin C + H2O => acetate + deacetylcephalosporin C + H(+)"}
{"X":16082,"RHEA_ID":12769,"DIRECTION":"UN","MASTER_ID":12769,"ec":"1.1.99.3","compounds":"A + D-gluconate = 2-dehydro-D-gluconate + AH2"}
{"X":16083,"RHEA_ID":12770,"DIRECTION":"LR","MASTER_ID":12769,"metacyc":"GLUCONATE-2-DEHYDROGENASE-RXN","compounds":"A + D-gluconate => 2-dehydro-D-gluconate + AH2"}
{"X":16084,"RHEA_ID":12771,"compounds":"2-dehydro-D-gluconate + AH2 => A + D-gluconate"}
{"X":16085,"RHEA_ID":22601,"DIRECTION":"LR","MASTER_ID":22600,"metacyc":"RXN-13182","compounds":"H2O + N-acetyl-9-O-acetylneuraminate => acetate + H(+) + N-acetylneuraminate"}
{"X":16086,"RHEA_ID":12773,"DIRECTION":"UN","MASTER_ID":12773,"ec":"1.14.11.21","compounds":"2-oxoglutarate + O2 + proclavaminate = CO2 + dihydroclavaminate + H2O + succinate"}
{"X":16087,"RHEA_ID":12774,"DIRECTION":"LR","MASTER_ID":12773,"metacyc":"RXN-6266","compounds":"2-oxoglutarate + O2 + proclavaminate => CO2 + dihydroclavaminate + H2O + succinate"}
{"X":16088,"RHEA_ID":12775,"compounds":"CO2 + dihydroclavaminate + H2O + succinate => 2-oxoglutarate + O2 + proclavaminate"}
{"X":16089,"RHEA_ID":22605,"compounds":"D-mannose => D-fructose"}
{"X":16090,"RHEA_ID":12777,"DIRECTION":"UN","MASTER_ID":12777,"ec":"1.17.3.1","compounds":"2-amino-4-hydroxypteridine + O2 = 2-amino-4,7-dihydroxypteridine + chemical entity"}
{"X":16091,"RHEA_ID":12778,"DIRECTION":"LR","MASTER_ID":12777,"metacyc":"PTERIDINE-OXIDASE-RXN","compounds":"2-amino-4-hydroxypteridine + O2 => 2-amino-4,7-dihydroxypteridine + chemical entity"}
{"X":16092,"RHEA_ID":12779,"compounds":"2-amino-4,7-dihydroxypteridine + chemical entity => 2-amino-4-hydroxypteridine + O2"}
{"X":16093,"RHEA_ID":22609,"compounds":"H2O + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate => (2S,6S)-2,6-diaminoheptanedioate + succinate"}
{"X":16094,"RHEA_ID":12785,"DIRECTION":"UN","MASTER_ID":12785,"ec":"1.1.1.21","compounds":"an alditol + NAD(+) = an aldose + H(+) + NADH"}
{"X":16095,"RHEA_ID":12786,"compounds":"an alditol + NAD(+) => an aldose + H(+) + NADH"}
{"X":16096,"RHEA_ID":12787,"compounds":"an aldose + H(+) + NADH => an alditol + NAD(+)"}
{"X":16097,"RHEA_ID":12789,"DIRECTION":"UN","MASTER_ID":12789,"ec":"1.1.1.21","compounds":"an alditol + NADP(+) = an aldose + H(+) + NADPH"}
{"X":16098,"RHEA_ID":12790,"compounds":"an alditol + NADP(+) => an aldose + H(+) + NADPH"}
{"X":16099,"RHEA_ID":12791,"compounds":"an aldose + H(+) + NADPH => an alditol + NADP(+)"}
{"X":16100,"RHEA_ID":12793,"DIRECTION":"UN","MASTER_ID":12793,"ec":"2.7.4.21","compounds":"1D-myo-inositol hexakisphosphate + ATP = 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ADP"}
{"X":16101,"RHEA_ID":12794,"DIRECTION":"LR","MASTER_ID":12793,"metacyc":"2.7.1.152-RXN","reactome":"R-HSA-1855227.2","compounds":"1D-myo-inositol hexakisphosphate + ATP => 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ADP"}
{"X":16102,"RHEA_ID":12794,"DIRECTION":"LR","MASTER_ID":12793,"metacyc":"2.7.1.152-RXN","reactome":"R-HSA-1855207.2","compounds":"1D-myo-inositol hexakisphosphate + ATP => 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ADP"}
{"X":16103,"RHEA_ID":12795,"compounds":"5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ADP => 1D-myo-inositol hexakisphosphate + ATP"}
{"X":16104,"RHEA_ID":22622,"compounds":"3-indoleglycolaldehyde + CO2 + NH4(+) => H(+) + L-tryptophan + O2"}
{"X":16105,"RHEA_ID":12797,"DIRECTION":"UN","MASTER_ID":12797,"ec":"1.14.20.13","compounds":"(6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2 = CO2 + H(+) + H2O + scopolamine + succinate"}
{"X":16106,"RHEA_ID":12798,"DIRECTION":"LR","MASTER_ID":12797,"metacyc":"6-BETA-HYDROXYHYOSCYAMINE-EPOXIDASE-RXN","compounds":"(6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2 => CO2 + H(+) + H2O + scopolamine + succinate"}
{"X":16107,"RHEA_ID":12799,"compounds":"CO2 + H(+) + H2O + scopolamine + succinate => (6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2"}
{"X":16108,"RHEA_ID":22626,"compounds":"acetaldehyde + pyruvate => (S)-4-hydroxy-2-oxopentanoate"}
{"X":16109,"RHEA_ID":12801,"DIRECTION":"UN","MASTER_ID":12801,"ec":"2.7.11.26","compounds":"[tau protein]-L-serine + ATP = [tau protein]-O-phospho-L-serine + ADP + H(+)"}
{"X":16110,"RHEA_ID":12802,"compounds":"[tau protein]-L-serine + ATP => [tau protein]-O-phospho-L-serine + ADP + H(+)"}
{"X":16111,"RHEA_ID":12803,"compounds":"[tau protein]-O-phospho-L-serine + ADP + H(+) => [tau protein]-L-serine + ATP"}
{"X":16112,"RHEA_ID":22630,"compounds":"(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate => 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate"}
{"X":16113,"RHEA_ID":12805,"DIRECTION":"UN","MASTER_ID":12805,"ec":"2.1.1.122","compounds":"(S)-canadine + S-adenosyl-L-methionine = (S)-N-methylcanadine + S-adenosyl-L-homocysteine"}
{"X":16114,"RHEA_ID":12806,"DIRECTION":"LR","MASTER_ID":12805,"metacyc":"2.1.1.122-RXN","compounds":"(S)-canadine + S-adenosyl-L-methionine => (S)-N-methylcanadine + S-adenosyl-L-homocysteine"}
{"X":16115,"RHEA_ID":12807,"compounds":"(S)-N-methylcanadine + S-adenosyl-L-homocysteine => (S)-canadine + S-adenosyl-L-methionine"}
{"X":16116,"RHEA_ID":22634,"compounds":"all-trans-hexaprenyl diphosphate + diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + isopentenyl diphosphate"}
{"X":16117,"RHEA_ID":12809,"DIRECTION":"UN","MASTER_ID":12809,"ec":"1.1.3.14","compounds":"4 catechol + 3 O2 = 2 dibenzo[1,4]dioxin-2,3-dione + 6 H2O"}
{"X":16118,"RHEA_ID":12810,"DIRECTION":"LR","MASTER_ID":12809,"metacyc":"CATECHOL-OXIDASE-DIMERIZING-RXN","compounds":"4 catechol + 3 O2 => 2 dibenzo[1,4]dioxin-2,3-dione + 6 H2O"}
{"X":16119,"RHEA_ID":12811,"compounds":"2 dibenzo[1,4]dioxin-2,3-dione + 6 H2O => 4 catechol + 3 O2"}
{"X":16120,"RHEA_ID":22636,"DIRECTION":"UN","MASTER_ID":22636,"ec":"3.6.1.12","compounds":"dCTP + H2O = dCMP + diphosphate + H(+)"}
{"X":16121,"RHEA_ID":12813,"DIRECTION":"UN","MASTER_ID":12813,"ec":"5.1.1.3","compounds":"L-glutamate = D-glutamate"}
{"X":16122,"RHEA_ID":12814,"DIRECTION":"LR","MASTER_ID":12813,"macie":"M0001","compounds":"L-glutamate => D-glutamate"}
{"X":16123,"RHEA_ID":12815,"compounds":"D-glutamate => L-glutamate"}
{"X":16124,"RHEA_ID":22640,"DIRECTION":"UN","MASTER_ID":22640,"ec":"1.1.1.102","compounds":"NADP(+) + sphinganine = 3-oxosphinganine + H(+) + NADPH"}
{"X":16125,"RHEA_ID":12817,"DIRECTION":"UN","MASTER_ID":12817,"ec":"1.3.1.46","metacyc":"BIOCHANIN-A-REDUCTASE-RXN","compounds":"2,3-dihydrobiochanin A + NADP(+) = biochanin A + 2 H(+) + NADPH"}
{"X":16126,"RHEA_ID":12818,"compounds":"2,3-dihydrobiochanin A + NADP(+) => biochanin A + 2 H(+) + NADPH"}
{"X":16127,"RHEA_ID":12819,"compounds":"biochanin A + 2 H(+) + NADPH => 2,3-dihydrobiochanin A + NADP(+)"}
{"X":16128,"RHEA_ID":22644,"DIRECTION":"UN","MASTER_ID":22644,"ec":"1.14.14.98","compounds":"O2 + protopine + reduced [NADPH--hemoprotein reductase] = 6-hydroxyprotopine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":16129,"RHEA_ID":12821,"DIRECTION":"UN","MASTER_ID":12821,"ec":"4.1.2.4","compounds":"2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate"}
{"X":16130,"RHEA_ID":12822,"compounds":"2-deoxy-D-ribose 5-phosphate => acetaldehyde + D-glyceraldehyde 3-phosphate"}
{"X":16131,"RHEA_ID":12823,"compounds":"acetaldehyde + D-glyceraldehyde 3-phosphate => 2-deoxy-D-ribose 5-phosphate"}
{"X":16132,"RHEA_ID":22648,"DIRECTION":"UN","MASTER_ID":22648,"ec":"4.4.1.17","compounds":"holo-[cytochrome c] = apo-[cytochrome c] + heme b"}
{"X":16133,"RHEA_ID":12825,"DIRECTION":"UN","MASTER_ID":12825,"ec":"1.21.4.3","compounds":"[thioredoxin]-disulfide + acetyl phosphate + H2O + methylamine = [thioredoxin]-dithiol + H(+) + phosphate + sarcosine"}
{"X":16134,"RHEA_ID":12826,"compounds":"[thioredoxin]-disulfide + acetyl phosphate + H2O + methylamine => [thioredoxin]-dithiol + H(+) + phosphate + sarcosine"}
{"X":16135,"RHEA_ID":12827,"compounds":"[thioredoxin]-dithiol + H(+) + phosphate + sarcosine => [thioredoxin]-disulfide + acetyl phosphate + H2O + methylamine"}
{"X":16136,"RHEA_ID":12829,"DIRECTION":"UN","MASTER_ID":12829,"ec":"4.3.1.2","compounds":"(2S,3S)-3-methyl-L-aspartate = mesaconate + NH4(+)"}
{"X":16137,"RHEA_ID":12830,"compounds":"(2S,3S)-3-methyl-L-aspartate => mesaconate + NH4(+)"}
{"X":16138,"RHEA_ID":12831,"compounds":"mesaconate + NH4(+) => (2S,3S)-3-methyl-L-aspartate"}
{"X":16139,"RHEA_ID":22656,"DIRECTION":"UN","MASTER_ID":22656,"ec":"2.7.8.4","metacyc":"SERINE-PHOSPHOETHANOLAMINE-SYNTHASE-RXN","compounds":"CDP-ethanolamine + L-serine = CMP + H(+) + L-serine-phosphoethanolamine"}
{"X":16140,"RHEA_ID":12833,"DIRECTION":"UN","MASTER_ID":12833,"ec":"3.5.1.82","metacyc":"3.5.1.82-RXN","compounds":"an N-acyl-D-glutamate + H2O = a carboxylate + D-glutamate"}
{"X":16141,"RHEA_ID":12834,"compounds":"an N-acyl-D-glutamate + H2O => a carboxylate + D-glutamate"}
{"X":16142,"RHEA_ID":12835,"compounds":"a carboxylate + D-glutamate => an N-acyl-D-glutamate + H2O"}
{"X":16143,"RHEA_ID":12837,"DIRECTION":"UN","MASTER_ID":12837,"ec":"2.7.1.32","compounds":"ATP + choline = ADP + H(+) + phosphocholine"}
{"X":16144,"RHEA_ID":12838,"DIRECTION":"LR","MASTER_ID":12837,"metacyc":"CHOLINE-KINASE-RXN","compounds":"ATP + choline => ADP + H(+) + phosphocholine"}
{"X":16145,"RHEA_ID":12839,"compounds":"ADP + H(+) + phosphocholine => ATP + choline"}
{"X":16146,"RHEA_ID":22664,"DIRECTION":"UN","MASTER_ID":22664,"ec":"2.3.1.103","compounds":"2 1-O-(trans-sinapoyl)-beta-D-glucose = 1,2-di-O-sinapoyl beta-D-glucose + D-glucose"}
{"X":16147,"RHEA_ID":12841,"DIRECTION":"UN","MASTER_ID":12841,"ec":"2.6.1.30","compounds":"pyridoxamine + pyruvate = L-alanine + pyridoxal"}
{"X":16148,"RHEA_ID":12842,"compounds":"pyridoxamine + pyruvate => L-alanine + pyridoxal"}
{"X":16149,"RHEA_ID":12843,"compounds":"L-alanine + pyridoxal => pyridoxamine + pyruvate"}
{"X":16150,"RHEA_ID":22668,"DIRECTION":"UN","MASTER_ID":22668,"ec":"2.4.1.182","compounds":"2-N,3-O-bis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl 1-phosphate + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine = H(+) + lipid A disaccharide (E. coli) + UDP"}
{"X":16151,"RHEA_ID":12845,"DIRECTION":"UN","MASTER_ID":12845,"ec":"3.4.15.6","compounds":"[L-4-(L-arginin-2-N-yl)aspartate](n) + H2O = [L-4-(L-arginin-2-N-yl)aspartate](n-1) + L-4-(L-arginin-2-N-yl)aspartate"}
{"X":16152,"RHEA_ID":12846,"compounds":"[L-4-(L-arginin-2-N-yl)aspartate](n) + H2O => [L-4-(L-arginin-2-N-yl)aspartate](n-1) + L-4-(L-arginin-2-N-yl)aspartate"}
{"X":16153,"RHEA_ID":12847,"compounds":"[L-4-(L-arginin-2-N-yl)aspartate](n-1) + L-4-(L-arginin-2-N-yl)aspartate => [L-4-(L-arginin-2-N-yl)aspartate](n) + H2O"}
{"X":16154,"RHEA_ID":12849,"DIRECTION":"UN","MASTER_ID":12849,"ec":"3.1.3.53","compounds":"[myosin light chain]-O-phospho-L-serine + H2O = [myosin light chain]-L-serine + phosphate"}
{"X":16155,"RHEA_ID":12850,"DIRECTION":"LR","MASTER_ID":12849,"metacyc":"MYOSIN-LIGHT-CHAIN-PHOSPHATASE-RXN","compounds":"[myosin light chain]-O-phospho-L-serine + H2O => [myosin light chain]-L-serine + phosphate"}
{"X":16156,"RHEA_ID":12851,"compounds":"[myosin light chain]-L-serine + phosphate => [myosin light chain]-O-phospho-L-serine + H2O"}
{"X":16157,"RHEA_ID":12853,"DIRECTION":"UN","MASTER_ID":12853,"ec":"2.4.1.85","compounds":"(S)-4-hydroxymandelonitrile + UDP-alpha-D-glucose = dhurrin + H(+) + UDP"}
{"X":16158,"RHEA_ID":12854,"compounds":"(S)-4-hydroxymandelonitrile + UDP-alpha-D-glucose => dhurrin + H(+) + UDP"}
{"X":16159,"RHEA_ID":12855,"compounds":"dhurrin + H(+) + UDP => (S)-4-hydroxymandelonitrile + UDP-alpha-D-glucose"}
{"X":16160,"RHEA_ID":22680,"DIRECTION":"UN","MASTER_ID":22680,"ec":"3.5.4.13","compounds":"dCTP + H(+) + H2O = dUTP + NH4(+)"}
{"X":16161,"RHEA_ID":12857,"DIRECTION":"UN","MASTER_ID":12857,"ec":"5.4.99.1","compounds":"(2S,3S)-3-methyl-L-aspartate = L-glutamate"}
{"X":16162,"RHEA_ID":12858,"compounds":"(2S,3S)-3-methyl-L-aspartate => L-glutamate"}
{"X":16163,"RHEA_ID":12859,"DIRECTION":"RL","MASTER_ID":12857,"macie":"M0063","metacyc":"METHYLASPARTATE-MUTASE-RXN","compounds":"L-glutamate => (2S,3S)-3-methyl-L-aspartate"}
{"X":16164,"RHEA_ID":22684,"DIRECTION":"UN","MASTER_ID":22684,"ec":"1.14.99.65","compounds":"4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AH2 + O2 = (2R)-2-(4-aminophenyl)-L-seryl-[peptidyl-carrier protein] + A + H2O"}
{"X":16165,"RHEA_ID":12861,"DIRECTION":"UN","MASTER_ID":12861,"ec":"3.5.4.15","compounds":"guanosine + H(+) + H2O = NH4(+) + xanthosine"}
{"X":16166,"RHEA_ID":12862,"DIRECTION":"LR","MASTER_ID":12861,"metacyc":"GUANOSINE-DEAMINASE-RXN","compounds":"guanosine + H(+) + H2O => NH4(+) + xanthosine"}
{"X":16167,"RHEA_ID":12863,"compounds":"NH4(+) + xanthosine => guanosine + H(+) + H2O"}
{"X":16168,"RHEA_ID":22688,"DIRECTION":"UN","MASTER_ID":22688,"ec":"1.4.3.19","compounds":"D-alanine + H2O + O2 = H2O2 + NH4(+) + pyruvate"}
{"X":16169,"RHEA_ID":12865,"DIRECTION":"UN","MASTER_ID":12865,"ec":"3.2.2.13","compounds":"1-methyladenosine + H2O = 1-methyladenine + D-ribose"}
{"X":16170,"RHEA_ID":12866,"DIRECTION":"LR","MASTER_ID":12865,"metacyc":"1-METHYLADENOSINE-NUCLEOSIDASE-RXN","compounds":"1-methyladenosine + H2O => 1-methyladenine + D-ribose"}
{"X":16171,"RHEA_ID":12867,"compounds":"1-methyladenine + D-ribose => 1-methyladenosine + H2O"}
{"X":16172,"RHEA_ID":22692,"DIRECTION":"UN","MASTER_ID":22692,"ec":"1.14.13.24","compounds":"3-hydroxybenzoate + H(+) + NADH + O2 = 2,5-dihydroxybenzoate + H2O + NAD(+)"}
{"X":16173,"RHEA_ID":12869,"DIRECTION":"UN","MASTER_ID":12869,"ec":"4.2.3.16","compounds":"(2E)-geranyl diphosphate = (4S)-limonene + diphosphate"}
{"X":16174,"RHEA_ID":12870,"DIRECTION":"LR","MASTER_ID":12869,"metacyc":"4.2.3.16-RXN","compounds":"(2E)-geranyl diphosphate => (4S)-limonene + diphosphate"}
{"X":16175,"RHEA_ID":12871,"compounds":"(4S)-limonene + diphosphate => (2E)-geranyl diphosphate"}
{"X":16176,"RHEA_ID":22696,"DIRECTION":"UN","MASTER_ID":22696,"ec":"1.14.99.12","compounds":"AH2 + androst-4-ene-3,17-dione + O2 = A + H2O + testololactone"}
{"X":16177,"RHEA_ID":12873,"DIRECTION":"UN","MASTER_ID":12873,"ec":"1.1.1.272","compounds":"(R)-2-hydroxy-4-methylpentanoate + NADP(+) = 4-methyl-2-oxopentanoate + H(+) + NADPH"}
{"X":16178,"RHEA_ID":12874,"compounds":"(R)-2-hydroxy-4-methylpentanoate + NADP(+) => 4-methyl-2-oxopentanoate + H(+) + NADPH"}
{"X":16179,"RHEA_ID":12875,"DIRECTION":"RL","MASTER_ID":12873,"metacyc":"RXN-17525","compounds":"4-methyl-2-oxopentanoate + H(+) + NADPH => (R)-2-hydroxy-4-methylpentanoate + NADP(+)"}
{"X":16180,"RHEA_ID":12876,"compounds":"(R)-2-hydroxy-4-methylpentanoate + NADP(+) <=> 4-methyl-2-oxopentanoate + H(+) + NADPH"}
{"X":16181,"RHEA_ID":12877,"DIRECTION":"UN","MASTER_ID":12877,"ec":"1.13.11.50","compounds":"acetylacetone + O2 = acetate + H(+) + methylglyoxal"}
{"X":16182,"RHEA_ID":12878,"DIRECTION":"LR","MASTER_ID":12877,"metacyc":"RXN-12017","compounds":"acetylacetone + O2 => acetate + H(+) + methylglyoxal"}
{"X":16183,"RHEA_ID":12879,"compounds":"acetate + H(+) + methylglyoxal => acetylacetone + O2"}
{"X":16184,"RHEA_ID":12881,"DIRECTION":"UN","MASTER_ID":12881,"ec":"2.4.1.213","compounds":"ADP-alpha-D-glucose + sn-glycerol 3-phosphate = 2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + ADP + H(+)"}
{"X":16185,"RHEA_ID":12882,"compounds":"ADP-alpha-D-glucose + sn-glycerol 3-phosphate => 2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + ADP + H(+)"}
{"X":16186,"RHEA_ID":12883,"compounds":"2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + ADP + H(+) => ADP-alpha-D-glucose + sn-glycerol 3-phosphate"}
{"X":16187,"RHEA_ID":22708,"DIRECTION":"UN","MASTER_ID":22708,"ec":"3.1.2.7","compounds":"H2O + S-acylglutathione = a carboxylate + glutathione + H(+)"}
{"X":16188,"RHEA_ID":12885,"DIRECTION":"UN","MASTER_ID":12885,"ec":"2.4.1.110","metacyc":"2.4.1.110-RXN","compounds":"GDP-alpha-D-mannose + queuosine 5'-phosphate in tRNA(Asp) = beta-D-mannosyl-5''-O-queuosine 5'-phosphate in tRNA(Asp) + GDP + H(+)"}
{"X":16189,"RHEA_ID":12886,"compounds":"GDP-alpha-D-mannose + queuosine 5'-phosphate in tRNA(Asp) => beta-D-mannosyl-5''-O-queuosine 5'-phosphate in tRNA(Asp) + GDP + H(+)"}
{"X":16190,"RHEA_ID":12887,"compounds":"beta-D-mannosyl-5''-O-queuosine 5'-phosphate in tRNA(Asp) + GDP + H(+) => GDP-alpha-D-mannose + queuosine 5'-phosphate in tRNA(Asp)"}
{"X":16191,"RHEA_ID":22712,"DIRECTION":"UN","MASTER_ID":22712,"ec":"2.7.7.62","compounds":"adenosylcob(III)inamide phosphate + GTP + H(+) = adenosylcob(III)inamide-GDP + diphosphate"}
{"X":16192,"RHEA_ID":12889,"DIRECTION":"UN","MASTER_ID":12889,"ec":"1.1.1.45","compounds":"L-gulonate + NAD(+) = 3-dehydro-L-gulonate + H(+) + NADH"}
{"X":16193,"RHEA_ID":12890,"DIRECTION":"LR","MASTER_ID":12889,"reactome":"R-HSA-5661290.2","compounds":"L-gulonate + NAD(+) => 3-dehydro-L-gulonate + H(+) + NADH"}
{"X":16194,"RHEA_ID":12891,"compounds":"3-dehydro-L-gulonate + H(+) + NADH => L-gulonate + NAD(+)"}
{"X":16195,"RHEA_ID":22716,"DIRECTION":"UN","MASTER_ID":22716,"ec":"1.14.14.25","compounds":"cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":16196,"RHEA_ID":12893,"DIRECTION":"UN","MASTER_ID":12893,"ec":"5.3.99.3","compounds":"prostaglandin H2 = prostaglandin E2"}
{"X":16197,"RHEA_ID":12894,"DIRECTION":"LR","MASTER_ID":12893,"macie":"M0192","metacyc":"PROSTAGLANDIN-E-SYNTHASE-RXN","reactome":"R-HSA-2161660.3","compounds":"prostaglandin H2 => prostaglandin E2"}
{"X":16198,"RHEA_ID":12894,"DIRECTION":"LR","MASTER_ID":12893,"macie":"M0192","metacyc":"PROSTAGLANDIN-E-SYNTHASE-RXN","reactome":"R-HSA-265295.2","compounds":"prostaglandin H2 => prostaglandin E2"}
{"X":16199,"RHEA_ID":12895,"compounds":"prostaglandin E2 => prostaglandin H2"}
{"X":16200,"RHEA_ID":22721,"DIRECTION":"LR","MASTER_ID":22720,"ecocyc":"2.7.13.1-RXN","metacyc":"2.7.13.1-RXN","compounds":"ATP + L-histidyl-[protein] => ADP + H(+) + N(pros)-phospho-L-histidyl-[protein]"}
{"X":16201,"RHEA_ID":12897,"DIRECTION":"UN","MASTER_ID":12897,"ec":"1.14.14.137","compounds":"2-cis-(+)-abscisate + O2 + reduced [NADPH--hemoprotein reductase] = (+)-8'-hydroxyabscisate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":16202,"RHEA_ID":12898,"DIRECTION":"LR","MASTER_ID":12897,"metacyc":"1.14.13.93-RXN","compounds":"2-cis-(+)-abscisate + O2 + reduced [NADPH--hemoprotein reductase] => (+)-8'-hydroxyabscisate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":16203,"RHEA_ID":12899,"compounds":"(+)-8'-hydroxyabscisate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 2-cis-(+)-abscisate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":16204,"RHEA_ID":22725,"DIRECTION":"LR","MASTER_ID":22724,"metacyc":"STEROL-GLUCOSYLTRANSFERASE-RXN","compounds":"a sterol + UDP-alpha-D-glucose => a sterol 3-beta-D-glucoside + H(+) + UDP"}
{"X":16205,"RHEA_ID":12901,"DIRECTION":"UN","MASTER_ID":12901,"ec":"3.5.3.10","compounds":"D-arginine + H2O = D-ornithine + urea"}
{"X":16206,"RHEA_ID":12902,"compounds":"D-arginine + H2O => D-ornithine + urea"}
{"X":16207,"RHEA_ID":12903,"compounds":"D-ornithine + urea => D-arginine + H2O"}
{"X":16208,"RHEA_ID":22729,"DIRECTION":"LR","MASTER_ID":22728,"ecocyc":"2.9.1.1-RXN","metacyc":"2.9.1.1-RXN","compounds":"H(+) + L-seryl-tRNA(Sec) + selenophosphate => L-selenocysteinyl-tRNA(Sec) + phosphate"}
{"X":16209,"RHEA_ID":12905,"DIRECTION":"UN","MASTER_ID":12905,"ec":"2.7.7.22","metacyc":"MANNPGUANYLTRANGDP-RXN","compounds":"alpha-D-mannose 1-phosphate + GDP + H(+) = GDP-alpha-D-mannose + phosphate"}
{"X":16210,"RHEA_ID":12906,"compounds":"alpha-D-mannose 1-phosphate + GDP + H(+) => GDP-alpha-D-mannose + phosphate"}
{"X":16211,"RHEA_ID":12907,"compounds":"GDP-alpha-D-mannose + phosphate => alpha-D-mannose 1-phosphate + GDP + H(+)"}
{"X":16212,"RHEA_ID":22733,"DIRECTION":"LR","MASTER_ID":22732,"metacyc":"4.1.1.83-RXN","compounds":"4-hydroxyphenylacetate + H(+) => 4-methylphenol + CO2"}
{"X":16213,"RHEA_ID":12909,"DIRECTION":"UN","MASTER_ID":12909,"ec":"1.9.6.1","compounds":"2 [Fe(II)cytochrome] + 2 H(+) + nitrate = 2 [Fe(III)cytochrome] + H2O + nitrite"}
{"X":16214,"RHEA_ID":12910,"compounds":"2 [Fe(II)cytochrome] + 2 H(+) + nitrate => 2 [Fe(III)cytochrome] + H2O + nitrite"}
{"X":16215,"RHEA_ID":12911,"compounds":"2 [Fe(III)cytochrome] + H2O + nitrite => 2 [Fe(II)cytochrome] + 2 H(+) + nitrate"}
{"X":16216,"RHEA_ID":12913,"compounds":"(R)-lipoate + ATP + H(+) = (R)-lipoyl-5'-AMP + diphosphate"}
{"X":16217,"RHEA_ID":12914,"DIRECTION":"LR","MASTER_ID":12913,"ecocyc":"RXN-8654","metacyc":"RXN-8654","compounds":"(R)-lipoate + ATP + H(+) => (R)-lipoyl-5'-AMP + diphosphate"}
{"X":16218,"RHEA_ID":12915,"compounds":"(R)-lipoyl-5'-AMP + diphosphate => (R)-lipoate + ATP + H(+)"}
{"X":16219,"RHEA_ID":22741,"compounds":"ATP + D-hexose => ADP + D-hexose 6-phosphate + H(+)"}
{"X":16220,"RHEA_ID":12917,"DIRECTION":"UN","MASTER_ID":12917,"ec":"3.2.1.105","compounds":"3alpha(S)-strictosidine + H2O = D-glucose + strictosidine aglycone"}
{"X":16221,"RHEA_ID":12918,"DIRECTION":"LR","MASTER_ID":12917,"metacyc":"STRICTOSIDINE-BETA-GLUCOSIDASE-RXN","compounds":"3alpha(S)-strictosidine + H2O => D-glucose + strictosidine aglycone"}
{"X":16222,"RHEA_ID":12919,"compounds":"D-glucose + strictosidine aglycone => 3alpha(S)-strictosidine + H2O"}
{"X":16223,"RHEA_ID":22745,"DIRECTION":"LR","MASTER_ID":22744,"metacyc":"2.1.1.62-RXN","compounds":"a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":16224,"RHEA_ID":12921,"DIRECTION":"UN","MASTER_ID":12921,"ec":"2.3.1.37","compounds":"glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO2 + CoA"}
{"X":16225,"RHEA_ID":12922,"DIRECTION":"LR","MASTER_ID":12921,"metacyc":"5-AMINOLEVULINIC-ACID-SYNTHASE-RXN","reactome":"R-HSA-189442.3","compounds":"glycine + H(+) + succinyl-CoA => 5-aminolevulinate + CO2 + CoA"}
{"X":16226,"RHEA_ID":12923,"compounds":"5-aminolevulinate + CO2 + CoA => glycine + H(+) + succinyl-CoA"}
{"X":16227,"RHEA_ID":22749,"compounds":"4-hydroxy-4-methyl-2-oxoglutarate => 2 pyruvate"}
{"X":16228,"RHEA_ID":12925,"compounds":"D-erythrose 4-phosphate + L-lysyl-[protein] = H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein]"}
{"X":16229,"RHEA_ID":12926,"compounds":"D-erythrose 4-phosphate + L-lysyl-[protein] => H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein]"}
{"X":16230,"RHEA_ID":12927,"compounds":"H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein] => D-erythrose 4-phosphate + L-lysyl-[protein]"}
{"X":16231,"RHEA_ID":12928,"compounds":"D-erythrose 4-phosphate + L-lysyl-[protein] <=> H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein]"}
{"X":16232,"RHEA_ID":12929,"DIRECTION":"UN","MASTER_ID":12929,"ec":"2.3.3.14","compounds":"2-oxoglutarate + acetyl-CoA + H2O = (2R)-homocitrate + CoA + H(+)"}
{"X":16233,"RHEA_ID":12930,"compounds":"2-oxoglutarate + acetyl-CoA + H2O => (2R)-homocitrate + CoA + H(+)"}
{"X":16234,"RHEA_ID":12931,"compounds":"(2R)-homocitrate + CoA + H(+) => 2-oxoglutarate + acetyl-CoA + H2O"}
{"X":16235,"RHEA_ID":22757,"DIRECTION":"LR","MASTER_ID":22756,"macie":"M0322","metacyc":"LONG-CHAIN-ALCOHOL-RXN-4444OXIDASE-RXN","compounds":"a long-chain primary fatty alcohol + O2 => a long-chain fatty aldehyde + H2O2"}
{"X":16236,"RHEA_ID":12933,"DIRECTION":"UN","MASTER_ID":12933,"ec":"4.1.2.17","compounds":"L-fuculose 1-phosphate = (S)-lactaldehyde + dihydroxyacetone phosphate"}
{"X":16237,"RHEA_ID":12934,"DIRECTION":"LR","MASTER_ID":12933,"macie":"M0072","compounds":"L-fuculose 1-phosphate => (S)-lactaldehyde + dihydroxyacetone phosphate"}
{"X":16238,"RHEA_ID":12935,"compounds":"(S)-lactaldehyde + dihydroxyacetone phosphate => L-fuculose 1-phosphate"}
{"X":16239,"RHEA_ID":22760,"DIRECTION":"UN","MASTER_ID":22760,"ec":"1.13.12.6","compounds":"Cypridina luciferin + O2 = CO2 + hnu + oxidized Cypridina luciferin"}
{"X":16240,"RHEA_ID":12937,"DIRECTION":"UN","MASTER_ID":12937,"ec":"2.3.1.23","compounds":"a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA"}
{"X":16241,"RHEA_ID":12938,"compounds":"a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA"}
{"X":16242,"RHEA_ID":12939,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA => a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA"}
{"X":16243,"RHEA_ID":12941,"DIRECTION":"UN","MASTER_ID":12941,"ec":"2.4.1.143","compounds":"N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP"}
{"X":16244,"RHEA_ID":12942,"DIRECTION":"LR","MASTER_ID":12941,"metacyc":"2.4.1.143-RXN","compounds":"N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP"}
{"X":16245,"RHEA_ID":12943,"compounds":"H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":16246,"RHEA_ID":12945,"DIRECTION":"UN","MASTER_ID":12945,"ec":"3.13.1.3","compounds":"2'-hydroxybiphenyl-2-sulfinate + H2O = 2-hydroxybiphenyl + H(+) + sulfite"}
{"X":16247,"RHEA_ID":12946,"compounds":"2'-hydroxybiphenyl-2-sulfinate + H2O => 2-hydroxybiphenyl + H(+) + sulfite"}
{"X":16248,"RHEA_ID":12947,"compounds":"2-hydroxybiphenyl + H(+) + sulfite => 2'-hydroxybiphenyl-2-sulfinate + H2O"}
{"X":16249,"RHEA_ID":22772,"DIRECTION":"UN","MASTER_ID":22772,"ec":"4.2.1.68","compounds":"L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H2O"}
{"X":16250,"RHEA_ID":12949,"DIRECTION":"UN","MASTER_ID":12949,"ec":"4.2.1.67","metacyc":"D-FUCONATE-HYDRATASE-RXN","compounds":"D-fuconate = 2-dehydro-3-deoxy-D-fuconate + H2O"}
{"X":16251,"RHEA_ID":12950,"compounds":"D-fuconate => 2-dehydro-3-deoxy-D-fuconate + H2O"}
{"X":16252,"RHEA_ID":12951,"compounds":"2-dehydro-3-deoxy-D-fuconate + H2O => D-fuconate"}
{"X":16253,"RHEA_ID":22776,"DIRECTION":"UN","MASTER_ID":22776,"ec":"1.11.1.13","compounds":"2 H(+) + H2O2 + 2 Mn(2+) = 2 H2O + 2 Mn(3+)"}
{"X":16254,"RHEA_ID":12953,"DIRECTION":"UN","MASTER_ID":12953,"ec":"2.7.11.9","metacyc":"2.7.11.9-RXN","compounds":"ATP + L-seryl-[Goodpasture antigen-binding protein] = ADP + H(+) + O-phospho-L-seryl-[Goodpasture antigen-binding protein]"}
{"X":16255,"RHEA_ID":12954,"compounds":"ATP + L-seryl-[Goodpasture antigen-binding protein] => ADP + H(+) + O-phospho-L-seryl-[Goodpasture antigen-binding protein]"}
{"X":16256,"RHEA_ID":12955,"compounds":"ADP + H(+) + O-phospho-L-seryl-[Goodpasture antigen-binding protein] => ATP + L-seryl-[Goodpasture antigen-binding protein]"}
{"X":16257,"RHEA_ID":12956,"compounds":"ATP + L-seryl-[Goodpasture antigen-binding protein] <=> ADP + H(+) + O-phospho-L-seryl-[Goodpasture antigen-binding protein]"}
{"X":16258,"RHEA_ID":12957,"DIRECTION":"UN","MASTER_ID":12957,"ec":"3.1.1.6","compounds":"an acetyl ester + H2O = acetate + an aliphatic alcohol + H(+)"}
{"X":16259,"RHEA_ID":12958,"DIRECTION":"LR","MASTER_ID":12957,"ecocyc":"ACETYLESTERASE-RXN","metacyc":"ACETYLESTERASE-RXN","compounds":"an acetyl ester + H2O => acetate + an aliphatic alcohol + H(+)"}
{"X":16260,"RHEA_ID":12959,"compounds":"acetate + an aliphatic alcohol + H(+) => an acetyl ester + H2O"}
{"X":16261,"RHEA_ID":12961,"DIRECTION":"UN","MASTER_ID":12961,"ec":"2.8.3.9","compounds":"acetoacetate + butanoyl-CoA = acetoacetyl-CoA + butanoate"}
{"X":16262,"RHEA_ID":12962,"compounds":"acetoacetate + butanoyl-CoA => acetoacetyl-CoA + butanoate"}
{"X":16263,"RHEA_ID":12963,"DIRECTION":"RL","MASTER_ID":12961,"metacyc":"2.8.3.9-RXN","compounds":"acetoacetyl-CoA + butanoate => acetoacetate + butanoyl-CoA"}
{"X":16264,"RHEA_ID":33396,"DIRECTION":"LR","MASTER_ID":33395,"metacyc":"RXN0-4121","compounds":"H2O + N(epsilon)-(5'-guanylyl)-N(alpha)-acetyl-L-lysine methyl ester => GMP + N(alpha)-acetyl-L-lysine methyl ester"}
{"X":16265,"RHEA_ID":12965,"DIRECTION":"UN","MASTER_ID":12965,"ec":"2.7.1.44","compounds":"ATP + D-galactupyranuronate = 1-phospho-alpha-D-galacturonate + ADP + H(+)"}
{"X":16266,"RHEA_ID":12966,"DIRECTION":"LR","MASTER_ID":12965,"metacyc":"GALACTURONOKINASE-RXN","compounds":"ATP + D-galactupyranuronate => 1-phospho-alpha-D-galacturonate + ADP + H(+)"}
{"X":16267,"RHEA_ID":12967,"compounds":"1-phospho-alpha-D-galacturonate + ADP + H(+) => ATP + D-galactupyranuronate"}
{"X":16268,"RHEA_ID":33400,"DIRECTION":"LR","MASTER_ID":33399,"ecocyc":"RXN0-17","metacyc":"RXN0-17","compounds":"N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-muramate(out) => L-histidyl-[protein] + N-acetyl-beta-D-muramate 6-phosphate(in)"}
{"X":16269,"RHEA_ID":12969,"DIRECTION":"UN","MASTER_ID":12969,"ec":"3.1.4.46","compounds":"a sn-glycero-3-phosphoester + H2O = an alcohol + H(+) + sn-glycerol 3-phosphate"}
{"X":16270,"RHEA_ID":12970,"DIRECTION":"LR","MASTER_ID":12969,"ecocyc":"GLYCPDIESTER-RXN","metacyc":"GLYCPDIESTER-RXN","compounds":"a sn-glycero-3-phosphoester + H2O => an alcohol + H(+) + sn-glycerol 3-phosphate"}
{"X":16271,"RHEA_ID":12971,"compounds":"an alcohol + H(+) + sn-glycerol 3-phosphate => a sn-glycero-3-phosphoester + H2O"}
{"X":16272,"RHEA_ID":12973,"DIRECTION":"UN","MASTER_ID":12973,"ec":"2.7.4.3","compounds":"AMP + ATP = 2 ADP"}
{"X":16273,"RHEA_ID":12974,"DIRECTION":"LR","MASTER_ID":12973,"macie":"M0290","reactome":"R-HSA-74220.5","compounds":"AMP + ATP => 2 ADP"}
{"X":16274,"RHEA_ID":12974,"DIRECTION":"LR","MASTER_ID":12973,"macie":"M0290","reactome":"R-HSA-6788798.1","compounds":"AMP + ATP => 2 ADP"}
{"X":16275,"RHEA_ID":12974,"DIRECTION":"LR","MASTER_ID":12973,"macie":"M0290","reactome":"R-HSA-110138.5","compounds":"AMP + ATP => 2 ADP"}
{"X":16276,"RHEA_ID":12974,"DIRECTION":"LR","MASTER_ID":12973,"macie":"M0290","reactome":"R-HSA-110145.4","compounds":"AMP + ATP => 2 ADP"}
{"X":16277,"RHEA_ID":12975,"DIRECTION":"RL","MASTER_ID":12973,"reactome":"R-HSA-110137.5","compounds":"2 ADP => AMP + ATP"}
{"X":16278,"RHEA_ID":12975,"DIRECTION":"RL","MASTER_ID":12973,"reactome":"R-HSA-110141.5","compounds":"2 ADP => AMP + ATP"}
{"X":16279,"RHEA_ID":12975,"DIRECTION":"RL","MASTER_ID":12973,"reactome":"R-HSA-110144.4","compounds":"2 ADP => AMP + ATP"}
{"X":16280,"RHEA_ID":22804,"DIRECTION":"UN","MASTER_ID":22804,"ec":"1.1.1.221","metacyc":"VOMIFOLIOL-4-DEHYDROGENASE-RXN","compounds":"(6S,9R)-vomifoliol + NAD(+) = (6S)-6-hydroxy-3-oxo-alpha-ionone + H(+) + NADH"}
{"X":16281,"RHEA_ID":12977,"DIRECTION":"UN","MASTER_ID":12977,"ec":"3.9.1.1","compounds":"H2O + N-phosphocreatine = creatine + phosphate"}
{"X":16282,"RHEA_ID":12978,"DIRECTION":"LR","MASTER_ID":12977,"ecocyc":"PHOSPHOAMIDASE-RXN","metacyc":"PHOSPHOAMIDASE-RXN","compounds":"H2O + N-phosphocreatine => creatine + phosphate"}
{"X":16283,"RHEA_ID":12979,"compounds":"creatine + phosphate => H2O + N-phosphocreatine"}
{"X":16284,"RHEA_ID":22808,"DIRECTION":"UN","MASTER_ID":22808,"ec":"1.17.3.3","compounds":"6-hydroxynicotinate + H2O + O2 = 2,6-dihydroxynicotinate + H2O2"}
{"X":16285,"RHEA_ID":12981,"DIRECTION":"UN","MASTER_ID":12981,"ec":"1.13.11.18","compounds":"H2O + O2 + S-sulfanylglutathione = glutathione + 2 H(+) + sulfite"}
{"X":16286,"RHEA_ID":12982,"DIRECTION":"LR","MASTER_ID":12981,"metacyc":"RXN-13161","compounds":"H2O + O2 + S-sulfanylglutathione => glutathione + 2 H(+) + sulfite"}
{"X":16287,"RHEA_ID":12983,"compounds":"glutathione + 2 H(+) + sulfite => H2O + O2 + S-sulfanylglutathione"}
{"X":16288,"RHEA_ID":22812,"DIRECTION":"UN","MASTER_ID":22812,"ec":"1.5.1.5","compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH"}
{"X":16289,"RHEA_ID":12985,"DIRECTION":"UN","MASTER_ID":12985,"ec":"2.4.1.68","compounds":"GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein]"}
{"X":16290,"RHEA_ID":12986,"compounds":"GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein]"}
{"X":16291,"RHEA_ID":12987,"compounds":"GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] => GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]"}
{"X":16292,"RHEA_ID":12989,"DIRECTION":"UN","MASTER_ID":12989,"ec":"3.1.4.49","compounds":"dolichyl beta-D-mannosyl phosphate + H2O = D-mannose + dolichyl phosphate + H(+)"}
{"X":16293,"RHEA_ID":12990,"DIRECTION":"LR","MASTER_ID":12989,"metacyc":"3.1.4.49-RXN","compounds":"dolichyl beta-D-mannosyl phosphate + H2O => D-mannose + dolichyl phosphate + H(+)"}
{"X":16294,"RHEA_ID":12991,"compounds":"D-mannose + dolichyl phosphate + H(+) => dolichyl beta-D-mannosyl phosphate + H2O"}
{"X":16295,"RHEA_ID":12993,"DIRECTION":"UN","MASTER_ID":12993,"ec":"1.3.8.10","compounds":"cyclohex-1-ene-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = cyclohexa-1,5-diene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":16296,"RHEA_ID":12994,"compounds":"cyclohex-1-ene-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => cyclohexa-1,5-diene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":16297,"RHEA_ID":12995,"compounds":"cyclohexa-1,5-diene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein] => cyclohex-1-ene-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":16298,"RHEA_ID":22824,"DIRECTION":"UN","MASTER_ID":22824,"ec":"2.4.2.2","compounds":"2'-deoxyuridine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + uracil"}
{"X":16299,"RHEA_ID":12997,"DIRECTION":"UN","MASTER_ID":12997,"ec":"2.3.1.130","metacyc":"2.3.1.130-RXN","compounds":"(E)-feruloyl-CoA + galactarate = 2-O-[(E)-feruloyl]-D-galactarate + CoA"}
{"X":16300,"RHEA_ID":12998,"compounds":"(E)-feruloyl-CoA + galactarate => 2-O-[(E)-feruloyl]-D-galactarate + CoA"}
{"X":16301,"RHEA_ID":12999,"compounds":"2-O-[(E)-feruloyl]-D-galactarate + CoA => (E)-feruloyl-CoA + galactarate"}
{"X":16302,"RHEA_ID":22828,"DIRECTION":"UN","MASTER_ID":22828,"ec":"3.6.1.31","compounds":"1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)"}
{"X":16303,"RHEA_ID":13001,"DIRECTION":"UN","MASTER_ID":13001,"ec":"3.1.3.72","compounds":"1D-myo-inositol hexakisphosphate + H2O = 1L-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate"}
{"X":16304,"RHEA_ID":13002,"DIRECTION":"LR","MASTER_ID":13001,"metacyc":"3.1.3.72-RXN","compounds":"1D-myo-inositol hexakisphosphate + H2O => 1L-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate"}
{"X":16305,"RHEA_ID":13003,"compounds":"1L-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate => 1D-myo-inositol hexakisphosphate + H2O"}
{"X":16306,"RHEA_ID":22832,"DIRECTION":"UN","MASTER_ID":22832,"ec":"3.5.3.13","compounds":"H2O + N-formimidoyl-L-glutamate = N-formyl-L-glutamate + NH4(+)"}
{"X":16307,"RHEA_ID":13005,"DIRECTION":"UN","MASTER_ID":13005,"ec":"2.1.1.115","compounds":"(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-methionine = H(+) + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-homocysteine"}
{"X":16308,"RHEA_ID":13006,"DIRECTION":"LR","MASTER_ID":13005,"metacyc":"2.1.1.115-RXN","compounds":"(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-methionine => H(+) + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-homocysteine"}
{"X":16309,"RHEA_ID":13007,"compounds":"H(+) + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-homocysteine => (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-methionine"}
{"X":16310,"RHEA_ID":22836,"DIRECTION":"UN","MASTER_ID":22836,"ec":"2.3.1.41","ecocyc":"2.3.1.41-RXN","metacyc":"2.3.1.41-RXN","compounds":"a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]"}
{"X":16311,"RHEA_ID":13009,"DIRECTION":"UN","MASTER_ID":13009,"ec":"3.5.1.9","compounds":"H2O + N-formyl-L-kynurenine = formate + H(+) + L-kynurenine"}
{"X":16312,"RHEA_ID":13010,"DIRECTION":"LR","MASTER_ID":13009,"metacyc":"ARYLFORMAMIDASE-RXN","compounds":"H2O + N-formyl-L-kynurenine => formate + H(+) + L-kynurenine"}
{"X":16313,"RHEA_ID":13011,"compounds":"formate + H(+) + L-kynurenine => H2O + N-formyl-L-kynurenine"}
{"X":16314,"RHEA_ID":22840,"DIRECTION":"UN","MASTER_ID":22840,"ec":"3.5.1.35","compounds":"D-glutamine + H2O = D-glutamate + NH4(+)"}
{"X":16315,"RHEA_ID":13013,"DIRECTION":"UN","MASTER_ID":13013,"ec":"2.4.1.87","compounds":"a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose = an alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP"}
{"X":16316,"RHEA_ID":13014,"DIRECTION":"LR","MASTER_ID":13013,"metacyc":"2.4.1.151-RXN","compounds":"a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose => an alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP"}
{"X":16317,"RHEA_ID":13015,"compounds":"an alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose"}
{"X":16318,"RHEA_ID":22844,"DIRECTION":"UN","MASTER_ID":22844,"ec":"1.14.14.135","compounds":"(6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] = glyceollin I + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":16319,"RHEA_ID":13017,"DIRECTION":"UN","MASTER_ID":13017,"ec":"2.4.2.9","compounds":"diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil"}
{"X":16320,"RHEA_ID":13018,"compounds":"diphosphate + UMP => 5-phospho-alpha-D-ribose 1-diphosphate + uracil"}
{"X":16321,"RHEA_ID":13019,"DIRECTION":"RL","MASTER_ID":13017,"ecocyc":"URACIL-PRIBOSYLTRANS-RXN","compounds":"5-phospho-alpha-D-ribose 1-diphosphate + uracil => diphosphate + UMP"}
{"X":16322,"RHEA_ID":22848,"compounds":"(3S)-hydroxyoctanedioyl-CoA + NAD(+) = 3-oxooctanedioyl-CoA + H(+) + NADH"}
{"X":16323,"RHEA_ID":13021,"DIRECTION":"UN","MASTER_ID":13021,"ec":"1.14.13.82","compounds":"4-hydroxy-3-methoxybenzoate + H(+) + NADH + O2 = 3,4-dihydroxybenzoate + formaldehyde + H2O + NAD(+)"}
{"X":16324,"RHEA_ID":13022,"DIRECTION":"LR","MASTER_ID":13021,"metacyc":"RXN-10891","compounds":"4-hydroxy-3-methoxybenzoate + H(+) + NADH + O2 => 3,4-dihydroxybenzoate + formaldehyde + H2O + NAD(+)"}
{"X":16325,"RHEA_ID":13023,"compounds":"3,4-dihydroxybenzoate + formaldehyde + H2O + NAD(+) => 4-hydroxy-3-methoxybenzoate + H(+) + NADH + O2"}
{"X":16326,"RHEA_ID":22852,"DIRECTION":"UN","MASTER_ID":22852,"ec":"2.6.1.51","compounds":"L-serine + pyruvate = 3-hydroxypyruvate + L-alanine"}
{"X":16327,"RHEA_ID":13025,"compounds":"3-methylbut-2-enoyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = N(6)-biotinyl-L-lysyl-[protein] + trans-3-methylglutaconyl-CoA"}
{"X":16328,"RHEA_ID":13026,"compounds":"3-methylbut-2-enoyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] => N(6)-biotinyl-L-lysyl-[protein] + trans-3-methylglutaconyl-CoA"}
{"X":16329,"RHEA_ID":13027,"compounds":"N(6)-biotinyl-L-lysyl-[protein] + trans-3-methylglutaconyl-CoA => 3-methylbut-2-enoyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein]"}
{"X":16330,"RHEA_ID":13028,"compounds":"3-methylbut-2-enoyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] <=> N(6)-biotinyl-L-lysyl-[protein] + trans-3-methylglutaconyl-CoA"}
{"X":16331,"RHEA_ID":13029,"DIRECTION":"UN","MASTER_ID":13029,"ec":"1.1.3.29","compounds":"H2O + N-acetyl-D-glucosamine + O2 = H(+) + H2O2 + N-acetyl-D-glucosaminate"}
{"X":16332,"RHEA_ID":13030,"compounds":"H2O + N-acetyl-D-glucosamine + O2 => H(+) + H2O2 + N-acetyl-D-glucosaminate"}
{"X":16333,"RHEA_ID":13031,"compounds":"H(+) + H2O2 + N-acetyl-D-glucosaminate => H2O + N-acetyl-D-glucosamine + O2"}
{"X":16334,"RHEA_ID":22860,"DIRECTION":"UN","MASTER_ID":22860,"ec":"2.7.7.18","compounds":"ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate"}
{"X":16335,"RHEA_ID":13033,"DIRECTION":"UN","MASTER_ID":13033,"ec":"5.3.1.26","compounds":"aldehydo-D-galactose 6-phosphate = keto-D-tagatose 6-phosphate"}
{"X":16336,"RHEA_ID":13034,"compounds":"aldehydo-D-galactose 6-phosphate => keto-D-tagatose 6-phosphate"}
{"X":16337,"RHEA_ID":13035,"compounds":"keto-D-tagatose 6-phosphate => aldehydo-D-galactose 6-phosphate"}
{"X":16338,"RHEA_ID":22862,"compounds":"deamido-NAD(+) + diphosphate => ATP + H(+) + nicotinate beta-D-ribonucleotide"}
{"X":16339,"RHEA_ID":13037,"DIRECTION":"UN","MASTER_ID":13037,"ec":"3.5.4.18","metacyc":"ATP-DEAMINASE-RXN","compounds":"ATP + H(+) + H2O = ITP + NH4(+)"}
{"X":16340,"RHEA_ID":13037,"DIRECTION":"UN","MASTER_ID":13037,"ec":"3.5.4.17","metacyc":"ATP-DEAMINASE-RXN","compounds":"ATP + H(+) + H2O = ITP + NH4(+)"}
{"X":16341,"RHEA_ID":13038,"compounds":"ATP + H(+) + H2O => ITP + NH4(+)"}
{"X":16342,"RHEA_ID":13039,"compounds":"ITP + NH4(+) => ATP + H(+) + H2O"}
{"X":16343,"RHEA_ID":33482,"compounds":"an acyl-CoA + lanosterol <=> CoA + lanosteryl ester"}
{"X":16344,"RHEA_ID":13041,"DIRECTION":"UN","MASTER_ID":13041,"ec":"5.3.3.12","compounds":"L-dopachrome = 5,6-dihydroxyindole-2-carboxylate"}
{"X":16345,"RHEA_ID":13042,"DIRECTION":"LR","MASTER_ID":13041,"metacyc":"DOPACHROME-DELTA-ISOMERASE-RXN","compounds":"L-dopachrome => 5,6-dihydroxyindole-2-carboxylate"}
{"X":16346,"RHEA_ID":13043,"compounds":"5,6-dihydroxyindole-2-carboxylate => L-dopachrome"}
{"X":16347,"RHEA_ID":33486,"compounds":"an acyl-CoA + ergosterol <=> CoA + ergosteryl ester"}
{"X":16348,"RHEA_ID":13045,"compounds":"ent-kaur-16-ene + O2 + reduced [NADPH--hemoprotein reductase] = ent-kaur-16-en-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":16349,"RHEA_ID":13046,"compounds":"ent-kaur-16-ene + O2 + reduced [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":16350,"RHEA_ID":13047,"compounds":"ent-kaur-16-en-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-kaur-16-ene + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":16351,"RHEA_ID":33490,"compounds":"2-hydroxyhexacosanoyl-CoA + 4-hydroxysphinganine <=> CoA + H(+) + N-(2-hydroxyhexacosanoyl)phytosphingosine"}
{"X":16352,"RHEA_ID":13049,"DIRECTION":"UN","MASTER_ID":13049,"ec":"5.3.1.12","compounds":"D-glucuronate = D-fructuronate"}
{"X":16353,"RHEA_ID":13050,"compounds":"D-glucuronate => D-fructuronate"}
{"X":16354,"RHEA_ID":13051,"compounds":"D-fructuronate => D-glucuronate"}
{"X":16355,"RHEA_ID":33494,"compounds":"2-hydroxyhexacosanoyl-CoA + sphinganine <=> CoA + H(+) + N-(2-hydroxyhexacosanoyl)sphinganine"}
{"X":16356,"RHEA_ID":13053,"DIRECTION":"UN","MASTER_ID":13053,"ec":"2.6.1.58","compounds":"L-phenylalanine + pyruvate = 3-phenylpyruvate + L-alanine"}
{"X":16357,"RHEA_ID":13054,"compounds":"L-phenylalanine + pyruvate => 3-phenylpyruvate + L-alanine"}
{"X":16358,"RHEA_ID":13055,"compounds":"3-phenylpyruvate + L-alanine => L-phenylalanine + pyruvate"}
{"X":16359,"RHEA_ID":33498,"compounds":"all-trans-heptaprenyl diphosphate + sn-glycerol 1-phosphate <=> 3-heptaprenyl-sn-glycero-1-phosphate + diphosphate"}
{"X":16360,"RHEA_ID":13057,"DIRECTION":"UN","MASTER_ID":13057,"ec":"3.1.3.29","compounds":"an N-acylneuraminate 9-phosphate + H2O = an N-acylneuraminate + phosphate"}
{"X":16361,"RHEA_ID":13058,"DIRECTION":"LR","MASTER_ID":13057,"metacyc":"N-ACYLNEURAMINATE-9-PHOSPHATASE-RXN","compounds":"an N-acylneuraminate 9-phosphate + H2O => an N-acylneuraminate + phosphate"}
{"X":16362,"RHEA_ID":13059,"compounds":"an N-acylneuraminate + phosphate => an N-acylneuraminate 9-phosphate + H2O"}
{"X":16363,"RHEA_ID":13061,"compounds":"O2 + S-sulfanylglutathione = glutathione S,S-dioxide + H(+)"}
{"X":16364,"RHEA_ID":13062,"DIRECTION":"LR","MASTER_ID":13061,"metacyc":"FESGSHTHIO-RXN","compounds":"O2 + S-sulfanylglutathione => glutathione S,S-dioxide + H(+)"}
{"X":16365,"RHEA_ID":13063,"compounds":"glutathione S,S-dioxide + H(+) => O2 + S-sulfanylglutathione"}
{"X":16366,"RHEA_ID":33506,"compounds":"ATP + H2O + itraconazole(in) <=> ADP + H(+) + itraconazole(out) + phosphate"}
{"X":16367,"RHEA_ID":13065,"DIRECTION":"UN","MASTER_ID":13065,"ec":"3.6.4.12","compounds":"ATP + H2O = ADP + H(+) + phosphate"}
{"X":16368,"RHEA_ID":13065,"DIRECTION":"UN","MASTER_ID":13065,"ec":"3.6.4.13","compounds":"ATP + H2O = ADP + H(+) + phosphate"}
{"X":16369,"RHEA_ID":13065,"DIRECTION":"UN","MASTER_ID":13065,"ec":"3.6.1.3","compounds":"ATP + H2O = ADP + H(+) + phosphate"}
{"X":16370,"RHEA_ID":13065,"DIRECTION":"UN","MASTER_ID":13065,"ec":"3.6.4.6","compounds":"ATP + H2O = ADP + H(+) + phosphate"}
{"X":16371,"RHEA_ID":13065,"DIRECTION":"UN","MASTER_ID":13065,"ec":"3.6.4.7","compounds":"ATP + H2O = ADP + H(+) + phosphate"}
{"X":16372,"RHEA_ID":13065,"DIRECTION":"UN","MASTER_ID":13065,"ec":"3.6.4.10","compounds":"ATP + H2O = ADP + H(+) + phosphate"}
{"X":16373,"RHEA_ID":13066,"DIRECTION":"LR","MASTER_ID":13065,"reactome":"R-HSA-1467466.1","compounds":"ATP + H2O => ADP + H(+) + phosphate"}
{"X":16374,"RHEA_ID":13066,"DIRECTION":"LR","MASTER_ID":13065,"reactome":"R-HSA-2466749.3","compounds":"ATP + H2O => ADP + H(+) + phosphate"}
{"X":16375,"RHEA_ID":13067,"compounds":"ADP + H(+) + phosphate => ATP + H2O"}
{"X":16376,"RHEA_ID":22901,"DIRECTION":"LR","MASTER_ID":22900,"metacyc":"ACETOINDEHYDROG-RXN","compounds":"(R)-acetoin + NAD(+) => diacetyl + H(+) + NADH"}
{"X":16377,"RHEA_ID":13069,"DIRECTION":"UN","MASTER_ID":13069,"ec":"2.7.1.82","compounds":"ATP + ethanolamine = ADP + H(+) + phosphoethanolamine"}
{"X":16378,"RHEA_ID":13070,"DIRECTION":"LR","MASTER_ID":13069,"metacyc":"ETHANOLAMINE-KINASE-RXN","reactome":"R-HSA-1483222.1","compounds":"ATP + ethanolamine => ADP + H(+) + phosphoethanolamine"}
{"X":16379,"RHEA_ID":13071,"compounds":"ADP + H(+) + phosphoethanolamine => ATP + ethanolamine"}
{"X":16380,"RHEA_ID":22905,"DIRECTION":"LR","MASTER_ID":22904,"metacyc":"RXN1F-160","compounds":"ent-7alpha-hydroxykaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase] => gibberellin A12 aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":16381,"RHEA_ID":13073,"DIRECTION":"UN","MASTER_ID":13073,"ec":"3.6.1.40","compounds":"guanosine 3'-diphosphate 5'-triphosphate + H2O = guanosine 3',5'-bis(diphosphate) + H(+) + phosphate"}
{"X":16382,"RHEA_ID":13074,"DIRECTION":"LR","MASTER_ID":13073,"ecocyc":"PPPGPPHYDRO-RXN","metacyc":"PPPGPPHYDRO-RXN","compounds":"guanosine 3'-diphosphate 5'-triphosphate + H2O => guanosine 3',5'-bis(diphosphate) + H(+) + phosphate"}
{"X":16383,"RHEA_ID":13075,"compounds":"guanosine 3',5'-bis(diphosphate) + H(+) + phosphate => guanosine 3'-diphosphate 5'-triphosphate + H2O"}
{"X":16384,"RHEA_ID":22909,"DIRECTION":"LR","MASTER_ID":22908,"metacyc":"RXN-18398","compounds":"3',5'-cyclic AMP + H(+) + H2O => 3',5'-cyclic IMP + NH4(+)"}
{"X":16385,"RHEA_ID":13077,"DIRECTION":"UN","MASTER_ID":13077,"ec":"2.7.1.61","metacyc":"2.7.1.61-RXN","compounds":"an acyl phosphate + D-hexose = a carboxylate + D-hexose phosphate + H(+)"}
{"X":16386,"RHEA_ID":13078,"compounds":"an acyl phosphate + D-hexose => a carboxylate + D-hexose phosphate + H(+)"}
{"X":16387,"RHEA_ID":13079,"compounds":"a carboxylate + D-hexose phosphate + H(+) => an acyl phosphate + D-hexose"}
{"X":16388,"RHEA_ID":13081,"DIRECTION":"UN","MASTER_ID":13081,"ec":"3.5.1.12","compounds":"biotin amide + H2O = biotin + NH4(+)"}
{"X":16389,"RHEA_ID":13082,"compounds":"biotin amide + H2O => biotin + NH4(+)"}
{"X":16390,"RHEA_ID":13083,"compounds":"biotin + NH4(+) => biotin amide + H2O"}
{"X":16391,"RHEA_ID":22917,"DIRECTION":"LR","MASTER_ID":22916,"metacyc":"1.14.13.84-RXN","compounds":"4'-hydroxyacetophenone + H(+) + NADPH + O2 => 4-acetoxyphenol + H2O + NADP(+)"}
{"X":16392,"RHEA_ID":13085,"DIRECTION":"UN","MASTER_ID":13085,"ec":"2.3.1.89","compounds":"(S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O = CoA + L-2-acetamido-6-oxoheptanedioate"}
{"X":16393,"RHEA_ID":13086,"DIRECTION":"LR","MASTER_ID":13085,"metacyc":"2.3.1.89-RXN","compounds":"(S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O => CoA + L-2-acetamido-6-oxoheptanedioate"}
{"X":16394,"RHEA_ID":13087,"compounds":"CoA + L-2-acetamido-6-oxoheptanedioate => (S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O"}
{"X":16395,"RHEA_ID":22921,"compounds":"L-glutamine + scyllo-inosose => 1-amino-1-deoxy-scyllo-inositol + 2-oxoglutaramate"}
{"X":16396,"RHEA_ID":13089,"DIRECTION":"UN","MASTER_ID":13089,"ec":"1.7.2.2","compounds":"6 [Fe(III)cytochrome c] + 2 H2O + NH4(+) = 6 [Fe(II)cytochrome c] + 8 H(+) + nitrite"}
{"X":16397,"RHEA_ID":13090,"compounds":"6 [Fe(III)cytochrome c] + 2 H2O + NH4(+) => 6 [Fe(II)cytochrome c] + 8 H(+) + nitrite"}
{"X":16398,"RHEA_ID":13091,"DIRECTION":"RL","MASTER_ID":13089,"ecocyc":"1.7.2.2-RXN","metacyc":"1.7.2.2-RXN","compounds":"6 [Fe(II)cytochrome c] + 8 H(+) + nitrite => 6 [Fe(III)cytochrome c] + 2 H2O + NH4(+)"}
{"X":16399,"RHEA_ID":13093,"DIRECTION":"UN","MASTER_ID":13093,"ec":"2.4.1.47","compounds":"an N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP"}
{"X":16400,"RHEA_ID":13094,"DIRECTION":"LR","MASTER_ID":13093,"metacyc":"2.4.1.47-RXN","compounds":"an N-acylsphing-4-enine + UDP-alpha-D-galactose => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP"}
{"X":16401,"RHEA_ID":13095,"compounds":"a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP => an N-acylsphing-4-enine + UDP-alpha-D-galactose"}
{"X":16402,"RHEA_ID":22929,"compounds":"4-acetamidobutanoyl-CoA + H2O => 4-aminobutanoyl-CoA + acetate"}
{"X":16403,"RHEA_ID":13097,"DIRECTION":"UN","MASTER_ID":13097,"ec":"4.2.1.59","compounds":"a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O"}
{"X":16404,"RHEA_ID":13098,"DIRECTION":"LR","MASTER_ID":13097,"ecocyc":"3-HYDROXYDECANOYL-ACP-DEHYDR-RXN","metacyc":"3-HYDROXYDECANOYL-ACP-DEHYDR-RXN","compounds":"a (3R)-hydroxyacyl-[ACP] => a (2E)-enoyl-[ACP] + H2O"}
{"X":16405,"RHEA_ID":13099,"compounds":"a (2E)-enoyl-[ACP] + H2O => a (3R)-hydroxyacyl-[ACP]"}
{"X":16406,"RHEA_ID":13101,"DIRECTION":"UN","MASTER_ID":13101,"ec":"4.2.1.49","compounds":"4-imidazolone-5-propanoate = H2O + trans-urocanate"}
{"X":16407,"RHEA_ID":13102,"compounds":"4-imidazolone-5-propanoate => H2O + trans-urocanate"}
{"X":16408,"RHEA_ID":13103,"DIRECTION":"RL","MASTER_ID":13101,"metacyc":"UROCANATE-HYDRATASE-RXN","reactome":"R-HSA-70903.3","compounds":"H2O + trans-urocanate => 4-imidazolone-5-propanoate"}
{"X":16409,"RHEA_ID":22937,"DIRECTION":"LR","MASTER_ID":22936,"ecocyc":"NAG6PDEACET-RXN","metacyc":"NAG6PDEACET-RXN","compounds":"H2O + N-acetyl-D-glucosamine 6-phosphate => acetate + D-glucosamine 6-phosphate"}
{"X":16410,"RHEA_ID":13105,"DIRECTION":"UN","MASTER_ID":13105,"ec":"3.1.3.19","compounds":"glycerol 2-phosphate + H2O = glycerol + phosphate"}
{"X":16411,"RHEA_ID":13106,"DIRECTION":"LR","MASTER_ID":13105,"ecocyc":"GLYCEROL-2-PHOSPHATASE-RXN","metacyc":"GLYCEROL-2-PHOSPHATASE-RXN","compounds":"glycerol 2-phosphate + H2O => glycerol + phosphate"}
{"X":16412,"RHEA_ID":13107,"compounds":"glycerol + phosphate => glycerol 2-phosphate + H2O"}
{"X":16413,"RHEA_ID":13109,"DIRECTION":"UN","MASTER_ID":13109,"ec":"1.7.1.12","metacyc":"1.7.1.12-RXN","compounds":"2-acetamidofluorene + H2O + NAD(+) = H(+) + N-hydroxy-2-acetamidofluorene + NADH"}
{"X":16414,"RHEA_ID":13110,"compounds":"2-acetamidofluorene + H2O + NAD(+) => H(+) + N-hydroxy-2-acetamidofluorene + NADH"}
{"X":16415,"RHEA_ID":13111,"compounds":"H(+) + N-hydroxy-2-acetamidofluorene + NADH => 2-acetamidofluorene + H2O + NAD(+)"}
{"X":16416,"RHEA_ID":22945,"compounds":"3beta-hydroxy-5beta-pregnane-20-one + NADP(+) => 5beta-pregnan-3,20-dione + H(+) + NADPH"}
{"X":16417,"RHEA_ID":13113,"DIRECTION":"UN","MASTER_ID":13113,"ec":"1.7.1.12","metacyc":"1.7.1.12-RXN","compounds":"2-acetamidofluorene + H2O + NADP(+) = H(+) + N-hydroxy-2-acetamidofluorene + NADPH"}
{"X":16418,"RHEA_ID":13114,"compounds":"2-acetamidofluorene + H2O + NADP(+) => H(+) + N-hydroxy-2-acetamidofluorene + NADPH"}
{"X":16419,"RHEA_ID":13115,"compounds":"H(+) + N-hydroxy-2-acetamidofluorene + NADPH => 2-acetamidofluorene + H2O + NADP(+)"}
{"X":16420,"RHEA_ID":22949,"DIRECTION":"LR","MASTER_ID":22948,"ecocyc":"TAGAALDOL-RXN","metacyc":"TAGAALDOL-RXN","compounds":"D-tagatofuranose 1,6-bisphosphate => D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate"}
{"X":16421,"RHEA_ID":13117,"DIRECTION":"UN","MASTER_ID":13117,"ec":"2.5.1.51","compounds":"O-acetyl-L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + acetate + H(+)"}
{"X":16422,"RHEA_ID":13118,"DIRECTION":"LR","MASTER_ID":13117,"metacyc":"2.5.1.51-RXN","compounds":"O-acetyl-L-serine + pyrazole => 3-(pyrazol-1-yl)-L-alanine + acetate + H(+)"}
{"X":16423,"RHEA_ID":13119,"compounds":"3-(pyrazol-1-yl)-L-alanine + acetate + H(+) => O-acetyl-L-serine + pyrazole"}
{"X":16424,"RHEA_ID":22953,"compounds":"O2 + octanedioyl-CoA => (2E)-octenedioyl-CoA + H2O2"}
{"X":16425,"RHEA_ID":13121,"DIRECTION":"UN","MASTER_ID":13121,"ec":"2.7.1.71","compounds":"ATP + shikimate = 3-phosphoshikimate + ADP + H(+)"}
{"X":16426,"RHEA_ID":13122,"DIRECTION":"LR","MASTER_ID":13121,"ecocyc":"SHIKIMATE-KINASE-RXN","compounds":"ATP + shikimate => 3-phosphoshikimate + ADP + H(+)"}
{"X":16427,"RHEA_ID":13123,"compounds":"3-phosphoshikimate + ADP + H(+) => ATP + shikimate"}
{"X":16428,"RHEA_ID":22957,"DIRECTION":"LR","MASTER_ID":22956,"metacyc":"PLASMANYLETHANOLAMINE-DESATURASE-RXN","compounds":"1-(1,2-saturated alkyl)-2-acyl-sn-glycero-3-phosphoethanolamine + AH2 + O2 => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + A + 2 H2O"}
{"X":16429,"RHEA_ID":13125,"DIRECTION":"UN","MASTER_ID":13125,"ec":"1.8.4.3","metacyc":"1.8.4.3-RXN","compounds":"CoA + glutathione disulfide = CoA-glutathione + glutathione"}
{"X":16430,"RHEA_ID":13126,"compounds":"CoA + glutathione disulfide => CoA-glutathione + glutathione"}
{"X":16431,"RHEA_ID":13127,"compounds":"CoA-glutathione + glutathione => CoA + glutathione disulfide"}
{"X":16432,"RHEA_ID":22961,"DIRECTION":"LR","MASTER_ID":22960,"metacyc":"RXN-3762","compounds":"formononetin + O2 + reduced [NADPH--hemoprotein reductase] => calycosin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":16433,"RHEA_ID":13129,"DIRECTION":"UN","MASTER_ID":13129,"ec":"2.4.1.209","compounds":"cis-4-coumarate + UDP-alpha-D-glucose = 4'-O-beta-D-glucosyl-cis-4-coumarate + H(+) + UDP"}
{"X":16434,"RHEA_ID":13130,"DIRECTION":"LR","MASTER_ID":13129,"metacyc":"2.4.1.209-RXN","compounds":"cis-4-coumarate + UDP-alpha-D-glucose => 4'-O-beta-D-glucosyl-cis-4-coumarate + H(+) + UDP"}
{"X":16435,"RHEA_ID":13131,"compounds":"4'-O-beta-D-glucosyl-cis-4-coumarate + H(+) + UDP => cis-4-coumarate + UDP-alpha-D-glucose"}
{"X":16436,"RHEA_ID":22965,"DIRECTION":"LR","MASTER_ID":22964,"ecocyc":"ORNDECARBOX-RXN","metacyc":"ORNDECARBOX-RXN","reactome":"R-HSA-70692.1","compounds":"H(+) + L-ornithine => CO2 + putrescine"}
{"X":16437,"RHEA_ID":13133,"DIRECTION":"UN","MASTER_ID":13133,"ec":"2.7.1.108","compounds":"CTP + di-trans,poly-cis-dolichol = CDP + dolichyl phosphate + H(+)"}
{"X":16438,"RHEA_ID":13134,"DIRECTION":"LR","MASTER_ID":13133,"metacyc":"DOLICHOL-KINASE-RXN","compounds":"CTP + di-trans,poly-cis-dolichol => CDP + dolichyl phosphate + H(+)"}
{"X":16439,"RHEA_ID":13135,"compounds":"CDP + dolichyl phosphate + H(+) => CTP + di-trans,poly-cis-dolichol"}
{"X":16440,"RHEA_ID":22969,"compounds":"butanal + CoA + NAD(+) => butanoyl-CoA + H(+) + NADH"}
{"X":16441,"RHEA_ID":13137,"DIRECTION":"UN","MASTER_ID":13137,"ec":"2.1.1.142","compounds":"cycloartenol + S-adenosyl-L-methionine = cyclolaudenol + H(+) + S-adenosyl-L-homocysteine"}
{"X":16442,"RHEA_ID":13138,"DIRECTION":"LR","MASTER_ID":13137,"metacyc":"2.1.1.142-RXN","compounds":"cycloartenol + S-adenosyl-L-methionine => cyclolaudenol + H(+) + S-adenosyl-L-homocysteine"}
{"X":16443,"RHEA_ID":13139,"compounds":"cyclolaudenol + H(+) + S-adenosyl-L-homocysteine => cycloartenol + S-adenosyl-L-methionine"}
{"X":16444,"RHEA_ID":22973,"compounds":"butanal + CoA + NADP(+) => butanoyl-CoA + H(+) + NADPH"}
{"X":16445,"RHEA_ID":13141,"DIRECTION":"UN","MASTER_ID":13141,"ec":"5.4.99.13","compounds":"2-methylpropanoyl-CoA = butanoyl-CoA"}
{"X":16446,"RHEA_ID":13142,"compounds":"2-methylpropanoyl-CoA => butanoyl-CoA"}
{"X":16447,"RHEA_ID":13143,"compounds":"butanoyl-CoA => 2-methylpropanoyl-CoA"}
{"X":16448,"RHEA_ID":22977,"DIRECTION":"LR","MASTER_ID":22976,"metacyc":"6.2.1.29-RXN","compounds":"(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate"}
{"X":16449,"RHEA_ID":13145,"DIRECTION":"UN","MASTER_ID":13145,"ec":"2.4.1.320","compounds":"4-O-beta-D-mannopyranosyl-N-acetyl-D-glucosamine + phosphate = alpha-D-mannose 1-phosphate + N-acetyl-D-glucosamine"}
{"X":16450,"RHEA_ID":13146,"compounds":"4-O-beta-D-mannopyranosyl-N-acetyl-D-glucosamine + phosphate => alpha-D-mannose 1-phosphate + N-acetyl-D-glucosamine"}
{"X":16451,"RHEA_ID":13147,"compounds":"alpha-D-mannose 1-phosphate + N-acetyl-D-glucosamine => 4-O-beta-D-mannopyranosyl-N-acetyl-D-glucosamine + phosphate"}
{"X":16452,"RHEA_ID":22981,"compounds":"a dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] => dolichyl diphosphate + H(+) + N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein]"}
{"X":16453,"RHEA_ID":13149,"DIRECTION":"UN","MASTER_ID":13149,"ec":"1.6.99.1","compounds":"A + H(+) + NADPH = AH2 + NADP(+)"}
{"X":16454,"RHEA_ID":13150,"DIRECTION":"LR","MASTER_ID":13149,"ecocyc":"NQOR-RXN","metacyc":"NQOR-RXN","compounds":"A + H(+) + NADPH => AH2 + NADP(+)"}
{"X":16455,"RHEA_ID":13151,"compounds":"AH2 + NADP(+) => A + H(+) + NADPH"}
{"X":16456,"RHEA_ID":13153,"DIRECTION":"UN","MASTER_ID":13153,"ec":"1.1.1.92","metacyc":"1.1.1.92-RXN","compounds":"(R)-glycerate + CO2 + NAD(+) = 2-hydroxy-3-oxosuccinate + 2 H(+) + NADH"}
{"X":16457,"RHEA_ID":13154,"compounds":"(R)-glycerate + CO2 + NAD(+) => 2-hydroxy-3-oxosuccinate + 2 H(+) + NADH"}
{"X":16458,"RHEA_ID":13155,"compounds":"2-hydroxy-3-oxosuccinate + 2 H(+) + NADH => (R)-glycerate + CO2 + NAD(+)"}
{"X":16459,"RHEA_ID":22989,"DIRECTION":"LR","MASTER_ID":22988,"metacyc":"RXN-9958","compounds":"3-oxopropanoate + CoA + NADP(+) => acetyl-CoA + CO2 + NADPH"}
{"X":16460,"RHEA_ID":13157,"DIRECTION":"UN","MASTER_ID":13157,"ec":"1.1.1.92","metacyc":"1.1.1.92-RXN","compounds":"(R)-glycerate + CO2 + NADP(+) = 2-hydroxy-3-oxosuccinate + 2 H(+) + NADPH"}
{"X":16461,"RHEA_ID":13158,"compounds":"(R)-glycerate + CO2 + NADP(+) => 2-hydroxy-3-oxosuccinate + 2 H(+) + NADPH"}
{"X":16462,"RHEA_ID":13159,"compounds":"2-hydroxy-3-oxosuccinate + 2 H(+) + NADPH => (R)-glycerate + CO2 + NADP(+)"}
{"X":16463,"RHEA_ID":22993,"DIRECTION":"LR","MASTER_ID":22992,"metacyc":"RXN-2902","compounds":"3-oxopropanoate + CoA + NAD(+) => acetyl-CoA + CO2 + NADH"}
{"X":16464,"RHEA_ID":13161,"DIRECTION":"UN","MASTER_ID":13161,"ec":"1.1.1.103","compounds":"L-threonine + NAD(+) = (2S)-2-amino-3-oxobutanoate + H(+) + NADH"}
{"X":16465,"RHEA_ID":13162,"DIRECTION":"LR","MASTER_ID":13161,"ecocyc":"THREODEHYD-RXN","metacyc":"THREODEHYD-RXN","reactome":"R-HSA-6798667.2","compounds":"L-threonine + NAD(+) => (2S)-2-amino-3-oxobutanoate + H(+) + NADH"}
{"X":16466,"RHEA_ID":13163,"compounds":"(2S)-2-amino-3-oxobutanoate + H(+) + NADH => L-threonine + NAD(+)"}
{"X":16467,"RHEA_ID":22996,"DIRECTION":"UN","MASTER_ID":22996,"ec":"1.11.1.11","compounds":"H2O2 + L-ascorbate = 2 H2O + L-dehydroascorbate"}
{"X":16468,"RHEA_ID":13169,"DIRECTION":"UN","MASTER_ID":13169,"ec":"5.2.1.1","compounds":"maleate = fumarate"}
{"X":16469,"RHEA_ID":13170,"compounds":"maleate => fumarate"}
{"X":16470,"RHEA_ID":13171,"compounds":"fumarate => maleate"}
{"X":16471,"RHEA_ID":23000,"DIRECTION":"UN","MASTER_ID":23000,"ec":"1.1.1.106","metacyc":"PANTOATE-4-DEHYDROGENASE-RXN","compounds":"(R)-pantoate + NAD(+) = (R)-4-dehydropantoate + H(+) + NADH"}
{"X":16472,"RHEA_ID":13173,"DIRECTION":"UN","MASTER_ID":13173,"ec":"1.20.1.1","compounds":"H2O + NAD(+) + phosphonate = H(+) + NADH + phosphate"}
{"X":16473,"RHEA_ID":13174,"DIRECTION":"LR","MASTER_ID":13173,"metacyc":"1.20.1.1-RXN","compounds":"H2O + NAD(+) + phosphonate => H(+) + NADH + phosphate"}
{"X":16474,"RHEA_ID":13175,"compounds":"H(+) + NADH + phosphate => H2O + NAD(+) + phosphonate"}
{"X":16475,"RHEA_ID":13177,"DIRECTION":"UN","MASTER_ID":13177,"ec":"4.1.2.29","compounds":"6-phospho-5-dehydro-2-deoxy-D-gluconate = 3-oxopropanoate + dihydroxyacetone phosphate"}
{"X":16476,"RHEA_ID":13178,"DIRECTION":"LR","MASTER_ID":13177,"metacyc":"4.1.2.29-RXN","compounds":"6-phospho-5-dehydro-2-deoxy-D-gluconate => 3-oxopropanoate + dihydroxyacetone phosphate"}
{"X":16477,"RHEA_ID":13179,"compounds":"3-oxopropanoate + dihydroxyacetone phosphate => 6-phospho-5-dehydro-2-deoxy-D-gluconate"}
{"X":16478,"RHEA_ID":23008,"DIRECTION":"UN","MASTER_ID":23008,"ec":"3.2.1.93","compounds":"alpha,alpha-trehalose 6-phosphate + H2O = D-glucose + D-glucose 6-phosphate"}
{"X":16479,"RHEA_ID":13181,"DIRECTION":"UN","MASTER_ID":13181,"ec":"7.3.2.4","compounds":"ATP + H2O + nitrate(out) = ADP + H(+) + nitrate(in) + phosphate"}
{"X":16480,"RHEA_ID":13182,"DIRECTION":"LR","MASTER_ID":13181,"metacyc":"3.6.3.26-RXN","compounds":"ATP + H2O + nitrate(out) => ADP + H(+) + nitrate(in) + phosphate"}
{"X":16481,"RHEA_ID":13183,"compounds":"ADP + H(+) + nitrate(in) + phosphate => ATP + H2O + nitrate(out)"}
{"X":16482,"RHEA_ID":13184,"compounds":"ATP + H2O + nitrate(out) <=> ADP + H(+) + nitrate(in) + phosphate"}
{"X":16483,"RHEA_ID":13185,"DIRECTION":"UN","MASTER_ID":13185,"ec":"2.5.1.61","compounds":"H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)"}
{"X":16484,"RHEA_ID":13186,"DIRECTION":"LR","MASTER_ID":13185,"ecocyc":"OHMETHYLBILANESYN-RXN","macie":"M0260","metacyc":"OHMETHYLBILANESYN-RXN","reactome":"R-HSA-189406.2","compounds":"H2O + 4 porphobilinogen => hydroxymethylbilane + 4 NH4(+)"}
{"X":16485,"RHEA_ID":13187,"compounds":"hydroxymethylbilane + 4 NH4(+) => H2O + 4 porphobilinogen"}
{"X":16486,"RHEA_ID":23016,"DIRECTION":"UN","MASTER_ID":23016,"ec":"1.1.1.219","compounds":"(2R,3S,4S)-3,4-leucopelargonidin + NADP(+) = (2R,3R)-dihydrokaempferol + H(+) + NADPH"}
{"X":16487,"RHEA_ID":13189,"DIRECTION":"UN","MASTER_ID":13189,"ec":"3.1.1.26","compounds":"a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+)"}
{"X":16488,"RHEA_ID":13190,"DIRECTION":"LR","MASTER_ID":13189,"metacyc":"GALACTOLIPASE-RXN","compounds":"a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O => 3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+)"}
{"X":16489,"RHEA_ID":13191,"compounds":"3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+) => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O"}
{"X":16490,"RHEA_ID":13193,"DIRECTION":"UN","MASTER_ID":13193,"ec":"5.4.99.18","compounds":"5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate"}
{"X":16491,"RHEA_ID":13194,"DIRECTION":"LR","MASTER_ID":13193,"ecocyc":"RXN0-743","metacyc":"RXN0-743","compounds":"5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) => 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate"}
{"X":16492,"RHEA_ID":13195,"compounds":"5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate => 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+)"}
{"X":16493,"RHEA_ID":23028,"DIRECTION":"UN","MASTER_ID":23028,"ec":"2.1.3.10","compounds":"malonyl-[ACP] + N(6)-biotinyl-L-lysyl-[protein] = acetyl-[ACP] + N(6)-carboxybiotinyl-L-lysyl-[protein]"}
{"X":16494,"RHEA_ID":13197,"DIRECTION":"UN","MASTER_ID":13197,"ec":"3.13.1.1","compounds":"H(+) + sulfite + UDP-alpha-D-glucose = H2O + UDP-alpha-D-6-sulfoquinovose"}
{"X":16495,"RHEA_ID":13198,"compounds":"H(+) + sulfite + UDP-alpha-D-glucose => H2O + UDP-alpha-D-6-sulfoquinovose"}
{"X":16496,"RHEA_ID":13199,"compounds":"H2O + UDP-alpha-D-6-sulfoquinovose => H(+) + sulfite + UDP-alpha-D-glucose"}
{"X":16497,"RHEA_ID":23032,"DIRECTION":"UN","MASTER_ID":23032,"ec":"6.3.3.1","compounds":"2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate"}
{"X":16498,"RHEA_ID":13201,"DIRECTION":"UN","MASTER_ID":13201,"ec":"2.1.4.1","compounds":"glycine + L-arginine = guanidinoacetate + L-ornithine"}
{"X":16499,"RHEA_ID":13202,"DIRECTION":"LR","MASTER_ID":13201,"macie":"M0018","metacyc":"GLYCINE-AMIDINOTRANSFERASE-RXN","reactome":"R-HSA-71275.2","compounds":"glycine + L-arginine => guanidinoacetate + L-ornithine"}
{"X":16500,"RHEA_ID":13203,"compounds":"guanidinoacetate + L-ornithine => glycine + L-arginine"}
{"X":16501,"RHEA_ID":23036,"compounds":"2 inosine + O2 = 2 5'-dehydroinosine + 2 H2O"}
{"X":16502,"RHEA_ID":13205,"DIRECTION":"UN","MASTER_ID":13205,"ec":"2.7.7.64","compounds":"a monosaccharide 1-phosphate + H(+) + UTP = a UDP-monosaccharide + diphosphate"}
{"X":16503,"RHEA_ID":13206,"compounds":"a monosaccharide 1-phosphate + H(+) + UTP => a UDP-monosaccharide + diphosphate"}
{"X":16504,"RHEA_ID":13207,"compounds":"a UDP-monosaccharide + diphosphate => a monosaccharide 1-phosphate + H(+) + UTP"}
{"X":16505,"RHEA_ID":13209,"compounds":"A + 3 H2O + trithionate = AH2 + 4 H(+) + 3 sulfite"}
{"X":16506,"RHEA_ID":13210,"compounds":"A + 3 H2O + trithionate => AH2 + 4 H(+) + 3 sulfite"}
{"X":16507,"RHEA_ID":13211,"compounds":"AH2 + 4 H(+) + 3 sulfite => A + 3 H2O + trithionate"}
{"X":16508,"RHEA_ID":13213,"DIRECTION":"UN","MASTER_ID":13213,"ec":"1.2.1.16","compounds":"H2O + NADP(+) + succinate semialdehyde = 2 H(+) + NADPH + succinate"}
{"X":16509,"RHEA_ID":13213,"DIRECTION":"UN","MASTER_ID":13213,"ec":"1.2.1.79","compounds":"H2O + NADP(+) + succinate semialdehyde = 2 H(+) + NADPH + succinate"}
{"X":16510,"RHEA_ID":13214,"DIRECTION":"LR","MASTER_ID":13213,"ecocyc":"SUCCSEMIALDDEHYDROG-RXN","metacyc":"RXN0-5293","compounds":"H2O + NADP(+) + succinate semialdehyde => 2 H(+) + NADPH + succinate"}
{"X":16511,"RHEA_ID":13214,"DIRECTION":"LR","MASTER_ID":13213,"ecocyc":"SUCCSEMIALDDEHYDROG-RXN","metacyc":"SUCCSEMIALDDEHYDROG-RXN","compounds":"H2O + NADP(+) + succinate semialdehyde => 2 H(+) + NADPH + succinate"}
{"X":16512,"RHEA_ID":13215,"compounds":"2 H(+) + NADPH + succinate => H2O + NADP(+) + succinate semialdehyde"}
{"X":16513,"RHEA_ID":23050,"compounds":"(R)-2-hydroxyglutarate + acetoacetate => (S)-3-hydroxybutanoate + 2-oxoglutarate"}
{"X":16514,"RHEA_ID":13217,"DIRECTION":"UN","MASTER_ID":13217,"ec":"1.2.1.16","compounds":"H2O + NAD(+) + succinate semialdehyde = 2 H(+) + NADH + succinate"}
{"X":16515,"RHEA_ID":13217,"DIRECTION":"UN","MASTER_ID":13217,"ec":"1.2.1.24","compounds":"H2O + NAD(+) + succinate semialdehyde = 2 H(+) + NADH + succinate"}
{"X":16516,"RHEA_ID":13218,"DIRECTION":"LR","MASTER_ID":13217,"ecocyc":"SUCCINATE-SEMIALDEHYDE-DEHYDROGENASE-RXN","metacyc":"RXN0-5293","reactome":"R-HSA-888548.3","compounds":"H2O + NAD(+) + succinate semialdehyde => 2 H(+) + NADH + succinate"}
{"X":16517,"RHEA_ID":13218,"DIRECTION":"LR","MASTER_ID":13217,"ecocyc":"SUCCINATE-SEMIALDEHYDE-DEHYDROGENASE-RXN","metacyc":"SUCCINATE-SEMIALDEHYDE-DEHYDROGENASE-RXN","reactome":"R-HSA-888548.3","compounds":"H2O + NAD(+) + succinate semialdehyde => 2 H(+) + NADH + succinate"}
{"X":16518,"RHEA_ID":13219,"compounds":"2 H(+) + NADH + succinate => H2O + NAD(+) + succinate semialdehyde"}
{"X":16519,"RHEA_ID":23056,"DIRECTION":"UN","MASTER_ID":23056,"ec":"4.2.1.69","compounds":"urea = cyanamide + H2O"}
{"X":16520,"RHEA_ID":13221,"DIRECTION":"UN","MASTER_ID":13221,"ec":"1.1.1.32","compounds":"(R)-mevalonate + NAD(+) = H(+) + mevaldate + NADH"}
{"X":16521,"RHEA_ID":13222,"compounds":"(R)-mevalonate + NAD(+) => H(+) + mevaldate + NADH"}
{"X":16522,"RHEA_ID":13223,"DIRECTION":"RL","MASTER_ID":13221,"metacyc":"MEVALDATE-REDUCTASE-RXN","compounds":"H(+) + mevaldate + NADH => (R)-mevalonate + NAD(+)"}
{"X":16523,"RHEA_ID":23060,"DIRECTION":"UN","MASTER_ID":23060,"ec":"6.1.3.1","compounds":"a (2R,3S)-2-alkyl-3-hydroxyalkanoate + ATP = a cis-3-alkyl-4-alkyloxetan-2-one + AMP + diphosphate"}
{"X":16524,"RHEA_ID":13233,"DIRECTION":"UN","MASTER_ID":13233,"ec":"2.4.2.1","compounds":"guanosine + phosphate = alpha-D-ribose 1-phosphate + guanine"}
{"X":16525,"RHEA_ID":13233,"DIRECTION":"UN","MASTER_ID":13233,"ec":"2.4.2.15","compounds":"guanosine + phosphate = alpha-D-ribose 1-phosphate + guanine"}
{"X":16526,"RHEA_ID":13234,"compounds":"guanosine + phosphate => alpha-D-ribose 1-phosphate + guanine"}
{"X":16527,"RHEA_ID":13235,"compounds":"alpha-D-ribose 1-phosphate + guanine => guanosine + phosphate"}
{"X":16528,"RHEA_ID":23065,"DIRECTION":"LR","MASTER_ID":23064,"ecocyc":"RXN0-280","metacyc":"RXN0-280","compounds":"an alkanesulfonate + FMNH2 + O2 => an aldehyde + FMN + 2 H(+) + H2O + sulfite"}
{"X":16529,"RHEA_ID":13237,"DIRECTION":"UN","MASTER_ID":13237,"ec":"2.6.1.16","compounds":"D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate"}
{"X":16530,"RHEA_ID":13238,"DIRECTION":"LR","MASTER_ID":13237,"ecocyc":"L-GLN-FRUCT-6-P-AMINOTRANS-RXN","metacyc":"L-GLN-FRUCT-6-P-AMINOTRANS-RXN","compounds":"D-fructose 6-phosphate + L-glutamine => D-glucosamine 6-phosphate + L-glutamate"}
{"X":16531,"RHEA_ID":13239,"compounds":"D-glucosamine 6-phosphate + L-glutamate => D-fructose 6-phosphate + L-glutamine"}
{"X":16532,"RHEA_ID":23069,"DIRECTION":"LR","MASTER_ID":23068,"metacyc":"ERYTHRONOLIDE-SYNTHASE-RXN","compounds":"6 (S)-methylmalonyl-CoA + 12 H(+) + 6 NADPH + propanoyl-CoA => 6-deoxyerythronolide B + 6 CO2 + 7 CoA + H2O + 6 NADP(+)"}
{"X":16533,"RHEA_ID":13241,"DIRECTION":"UN","MASTER_ID":13241,"ec":"2.7.1.52","compounds":"ATP + L-fucose = ADP + beta-L-fucose 1-phosphate + H(+)"}
{"X":16534,"RHEA_ID":13242,"DIRECTION":"LR","MASTER_ID":13241,"metacyc":"FUCOKINASE-RXN","compounds":"ATP + L-fucose => ADP + beta-L-fucose 1-phosphate + H(+)"}
{"X":16535,"RHEA_ID":13243,"compounds":"ADP + beta-L-fucose 1-phosphate + H(+) => ATP + L-fucose"}
{"X":16536,"RHEA_ID":23073,"compounds":"H(+) + oxaloacetate + phosphate => CO2 + H2O + phosphoenolpyruvate"}
{"X":16537,"RHEA_ID":13245,"DIRECTION":"UN","MASTER_ID":13245,"ec":"4.1.3.1","compounds":"isocitrate = glyoxylate + succinate"}
{"X":16538,"RHEA_ID":13246,"compounds":"isocitrate => glyoxylate + succinate"}
{"X":16539,"RHEA_ID":13247,"DIRECTION":"RL","MASTER_ID":13245,"macie":"M0272","compounds":"glyoxylate + succinate => isocitrate"}
{"X":16540,"RHEA_ID":23077,"compounds":"4-chlorobenzoyl-CoA + chloride + NADP(+) => 2,4-dichlorobenzoyl-CoA + NADPH"}
{"X":16541,"RHEA_ID":13249,"DIRECTION":"UN","MASTER_ID":13249,"ec":"1.1.1.268","compounds":"(R)-2-hydroxypropyl-coenzyme M + NAD(+) = 2-oxopropyl-coenzyme M + H(+) + NADH"}
{"X":16542,"RHEA_ID":13250,"DIRECTION":"LR","MASTER_ID":13249,"metacyc":"1.1.1.268-RXN","compounds":"(R)-2-hydroxypropyl-coenzyme M + NAD(+) => 2-oxopropyl-coenzyme M + H(+) + NADH"}
{"X":16543,"RHEA_ID":13251,"compounds":"2-oxopropyl-coenzyme M + H(+) + NADH => (R)-2-hydroxypropyl-coenzyme M + NAD(+)"}
{"X":16544,"RHEA_ID":23081,"compounds":"L-rhamnonate => 2-dehydro-3-deoxy-L-rhamnonate + H2O"}
{"X":16545,"RHEA_ID":13253,"DIRECTION":"UN","MASTER_ID":13253,"ec":"2.7.1.159","compounds":"1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)"}
{"X":16546,"RHEA_ID":13254,"DIRECTION":"LR","MASTER_ID":13253,"metacyc":"2.7.1.139-RXN","reactome":"R-HSA-1855172.2","compounds":"1D-myo-inositol 1,3,4-trisphosphate + ATP => 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)"}
{"X":16547,"RHEA_ID":13254,"DIRECTION":"LR","MASTER_ID":13253,"metacyc":"2.7.1.139-RXN","reactome":"R-HSA-994140.3","compounds":"1D-myo-inositol 1,3,4-trisphosphate + ATP => 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)"}
{"X":16548,"RHEA_ID":13255,"compounds":"1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+) => 1D-myo-inositol 1,3,4-trisphosphate + ATP"}
{"X":16549,"RHEA_ID":23086,"compounds":"7-methyl-3-oxooct-6-enoyl-CoA + acetate => 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA"}
{"X":16550,"RHEA_ID":13261,"DIRECTION":"UN","MASTER_ID":13261,"ec":"1.3.99.12","compounds":"2-methylbutanoyl-CoA + A = 2-methylbut-2-enoyl-CoA + AH2"}
{"X":16551,"RHEA_ID":13262,"compounds":"2-methylbutanoyl-CoA + A => 2-methylbut-2-enoyl-CoA + AH2"}
{"X":16552,"RHEA_ID":13263,"compounds":"2-methylbut-2-enoyl-CoA + AH2 => 2-methylbutanoyl-CoA + A"}
{"X":16553,"RHEA_ID":23090,"compounds":"1-O-alkylglycerone 3-phosphate + ADP + H(+) => ATP + O-alkylglycerone"}
{"X":16554,"RHEA_ID":13265,"DIRECTION":"UN","MASTER_ID":13265,"ec":"2.1.4.2","compounds":"1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine = 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithine"}
{"X":16555,"RHEA_ID":13266,"DIRECTION":"LR","MASTER_ID":13265,"metacyc":"2.1.4.2-RXN","compounds":"1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine => 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithine"}
{"X":16556,"RHEA_ID":13267,"compounds":"1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithine => 1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine"}
{"X":16557,"RHEA_ID":23094,"compounds":"ethylamine + N-isopropylammelide => H(+) + H2O + hydroxyatrazine"}
{"X":16558,"RHEA_ID":13269,"DIRECTION":"UN","MASTER_ID":13269,"ec":"3.2.1.45","compounds":"a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose"}
{"X":16559,"RHEA_ID":13270,"DIRECTION":"LR","MASTER_ID":13269,"metacyc":"GLUCOSYLCERAMIDASE-RXN","compounds":"a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O => an N-acylsphing-4-enine + D-glucose"}
{"X":16560,"RHEA_ID":13271,"compounds":"an N-acylsphing-4-enine + D-glucose => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O"}
{"X":16561,"RHEA_ID":13273,"DIRECTION":"UN","MASTER_ID":13273,"ec":"2.8.2.19","metacyc":"2.8.2.19-RXN","compounds":"3'-phosphoadenylyl sulfate + alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol = 6-sulfo-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol + adenosine 3',5'-bisphosphate + H(+)"}
{"X":16562,"RHEA_ID":13274,"compounds":"3'-phosphoadenylyl sulfate + alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol => 6-sulfo-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol + adenosine 3',5'-bisphosphate + H(+)"}
{"X":16563,"RHEA_ID":13275,"compounds":"6-sulfo-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol"}
{"X":16564,"RHEA_ID":23102,"DIRECTION":"RL","MASTER_ID":23100,"reactome":"R-HSA-110141.5","compounds":"ADP + dADP => ATP + dAMP"}
{"X":16565,"RHEA_ID":13277,"DIRECTION":"UN","MASTER_ID":13277,"ec":"6.3.2.29","compounds":"[L-4-(L-arginin-2-N-yl)aspartate](n) + ATP + L-aspartate = [L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ADP + H(+) + phosphate"}
{"X":16566,"RHEA_ID":13278,"DIRECTION":"LR","MASTER_ID":13277,"metacyc":"6.3.2.29-RXN","compounds":"[L-4-(L-arginin-2-N-yl)aspartate](n) + ATP + L-aspartate => [L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ADP + H(+) + phosphate"}
{"X":16567,"RHEA_ID":13279,"compounds":"[L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ADP + H(+) + phosphate => [L-4-(L-arginin-2-N-yl)aspartate](n) + ATP + L-aspartate"}
{"X":16568,"RHEA_ID":23106,"compounds":"D-ribulose 5-phosphate => D-arabinose 5-phosphate"}
{"X":16569,"RHEA_ID":13281,"DIRECTION":"UN","MASTER_ID":13281,"ec":"1.1.1.178","compounds":"(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) = 2-methyl-3-oxobutanoyl-CoA + H(+) + NADH"}
{"X":16570,"RHEA_ID":13282,"DIRECTION":"LR","MASTER_ID":13281,"reactome":"R-HSA-70837.3","compounds":"(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) => 2-methyl-3-oxobutanoyl-CoA + H(+) + NADH"}
{"X":16571,"RHEA_ID":13283,"DIRECTION":"RL","MASTER_ID":13281,"reactome":"R-HSA-508369.3","compounds":"2-methyl-3-oxobutanoyl-CoA + H(+) + NADH => (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+)"}
{"X":16572,"RHEA_ID":23110,"compounds":"D-arabinonate + H(+) => D-arabinono-1,4-lactone + H2O"}
{"X":16573,"RHEA_ID":13285,"DIRECTION":"UN","MASTER_ID":13285,"ec":"6.3.2.2","compounds":"ATP + L-cysteine + L-glutamate = ADP + H(+) + L-gamma-glutamyl-L-cysteine + phosphate"}
{"X":16574,"RHEA_ID":13286,"DIRECTION":"LR","MASTER_ID":13285,"ecocyc":"GLUTCYSLIG-RXN","metacyc":"GLUTCYSLIG-RXN","reactome":"R-HSA-174367.2","compounds":"ATP + L-cysteine + L-glutamate => ADP + H(+) + L-gamma-glutamyl-L-cysteine + phosphate"}
{"X":16575,"RHEA_ID":13287,"compounds":"ADP + H(+) + L-gamma-glutamyl-L-cysteine + phosphate => ATP + L-cysteine + L-glutamate"}
{"X":16576,"RHEA_ID":23114,"compounds":"3-methylphenol + CO2 => 6-methylsalicylate + H(+)"}
{"X":16577,"RHEA_ID":13289,"DIRECTION":"UN","MASTER_ID":13289,"ec":"2.7.8.15","compounds":"dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UMP"}
{"X":16578,"RHEA_ID":13290,"compounds":"dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine => N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UMP"}
{"X":16579,"RHEA_ID":13291,"compounds":"N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UMP => dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":16580,"RHEA_ID":23118,"compounds":"4-hydroxybenzoyl-CoA + AMP + diphosphate => 4-hydroxybenzoate + ATP + CoA"}
{"X":16581,"RHEA_ID":13293,"compounds":"3 H(+) + malonyl-CoA + 2 NADPH + octadecanoyl-CoA = CO2 + CoA + eicosanoyl-CoA + H2O + 2 NADP(+)"}
{"X":16582,"RHEA_ID":13294,"compounds":"3 H(+) + malonyl-CoA + 2 NADPH + octadecanoyl-CoA => CO2 + CoA + eicosanoyl-CoA + H2O + 2 NADP(+)"}
{"X":16583,"RHEA_ID":13295,"compounds":"CO2 + CoA + eicosanoyl-CoA + H2O + 2 NADP(+) => 3 H(+) + malonyl-CoA + 2 NADPH + octadecanoyl-CoA"}
{"X":16584,"RHEA_ID":23122,"compounds":"a dipeptide(in) + ADP + H(+) + phosphate => a dipeptide(out) + ATP + H2O"}
{"X":16585,"RHEA_ID":13297,"compounds":"3 H(+) + malonyl-CoA + 2 NADH + octadecanoyl-CoA = CO2 + CoA + eicosanoyl-CoA + H2O + 2 NAD(+)"}
{"X":16586,"RHEA_ID":13298,"compounds":"3 H(+) + malonyl-CoA + 2 NADH + octadecanoyl-CoA => CO2 + CoA + eicosanoyl-CoA + H2O + 2 NAD(+)"}
{"X":16587,"RHEA_ID":13299,"compounds":"CO2 + CoA + eicosanoyl-CoA + H2O + 2 NAD(+) => 3 H(+) + malonyl-CoA + 2 NADH + octadecanoyl-CoA"}
{"X":16588,"RHEA_ID":13301,"DIRECTION":"UN","MASTER_ID":13301,"ec":"2.3.1.73","compounds":"a 1,2-diacyl-sn-glycerol + a sterol = a 1-acyl-sn-glycerol + a sterol ester"}
{"X":16589,"RHEA_ID":13302,"compounds":"a 1,2-diacyl-sn-glycerol + a sterol => a 1-acyl-sn-glycerol + a sterol ester"}
{"X":16590,"RHEA_ID":13303,"compounds":"a 1-acyl-sn-glycerol + a sterol ester => a 1,2-diacyl-sn-glycerol + a sterol"}
{"X":16591,"RHEA_ID":13305,"DIRECTION":"UN","MASTER_ID":13305,"ec":"2.4.1.120","compounds":"trans-sinapate + UDP-alpha-D-glucose = 1-O-(trans-sinapoyl)-beta-D-glucose + UDP"}
{"X":16592,"RHEA_ID":13306,"DIRECTION":"LR","MASTER_ID":13305,"metacyc":"SINAPATE-1-GLUCOSYLTRANSFERASE-RXN","compounds":"trans-sinapate + UDP-alpha-D-glucose => 1-O-(trans-sinapoyl)-beta-D-glucose + UDP"}
{"X":16593,"RHEA_ID":13307,"compounds":"1-O-(trans-sinapoyl)-beta-D-glucose + UDP => trans-sinapate + UDP-alpha-D-glucose"}
{"X":16594,"RHEA_ID":23134,"DIRECTION":"RL","MASTER_ID":23132,"metacyc":"SULFITE-REDUCTASE-FERREDOXIN-RXN","compounds":"7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite => 3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":16595,"RHEA_ID":13309,"DIRECTION":"UN","MASTER_ID":13309,"ec":"1.2.1.67","compounds":"H2O + NAD(+) + vanillin = 4-hydroxy-3-methoxybenzoate + 2 H(+) + NADH"}
{"X":16596,"RHEA_ID":13310,"DIRECTION":"LR","MASTER_ID":13309,"metacyc":"1.2.1.67-RXN","compounds":"H2O + NAD(+) + vanillin => 4-hydroxy-3-methoxybenzoate + 2 H(+) + NADH"}
{"X":16597,"RHEA_ID":13311,"compounds":"4-hydroxy-3-methoxybenzoate + 2 H(+) + NADH => H2O + NAD(+) + vanillin"}
{"X":16598,"RHEA_ID":23138,"compounds":"a methylated primary amine + H(+) + S-adenosyl-L-homocysteine => a primary amine + S-adenosyl-L-methionine"}
{"X":16599,"RHEA_ID":13313,"DIRECTION":"UN","MASTER_ID":13313,"ec":"1.5.3.1","compounds":"H2O + O2 + sarcosine = formaldehyde + glycine + H2O2"}
{"X":16600,"RHEA_ID":13314,"DIRECTION":"LR","MASTER_ID":13313,"macie":"M0113","metacyc":"SARCOX-RXN","compounds":"H2O + O2 + sarcosine => formaldehyde + glycine + H2O2"}
{"X":16601,"RHEA_ID":13315,"compounds":"formaldehyde + glycine + H2O2 => H2O + O2 + sarcosine"}
{"X":16602,"RHEA_ID":13317,"DIRECTION":"UN","MASTER_ID":13317,"ec":"4.1.1.73","compounds":"(2R,3R)-tartrate + H(+) = (R)-glycerate + CO2"}
{"X":16603,"RHEA_ID":13318,"compounds":"(2R,3R)-tartrate + H(+) => (R)-glycerate + CO2"}
{"X":16604,"RHEA_ID":13319,"compounds":"(R)-glycerate + CO2 => (2R,3R)-tartrate + H(+)"}
{"X":16605,"RHEA_ID":23146,"compounds":"2 H(+) + N-acetyl-D-glucosaminate + NADH => H2O + N-acetyl-alpha-D-glucosamine + NAD(+)"}
{"X":16606,"RHEA_ID":13321,"DIRECTION":"UN","MASTER_ID":13321,"ec":"1.1.1.84","metacyc":"DIMETHYLMALATE-DEHYDROGENASE-RXN","compounds":"(R)-3,3-dimethylmalate + NAD(+) = 3-methyl-2-oxobutanoate + CO2 + NADH"}
{"X":16607,"RHEA_ID":13322,"compounds":"(R)-3,3-dimethylmalate + NAD(+) => 3-methyl-2-oxobutanoate + CO2 + NADH"}
{"X":16608,"RHEA_ID":13323,"compounds":"3-methyl-2-oxobutanoate + CO2 + NADH => (R)-3,3-dimethylmalate + NAD(+)"}
{"X":16609,"RHEA_ID":23150,"compounds":"ADP + propanoyl phosphate => ATP + propanoate"}
{"X":16610,"RHEA_ID":13325,"DIRECTION":"UN","MASTER_ID":13325,"ec":"1.1.1.136","compounds":"H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-glucosamine = 3 H(+) + 2 NADH + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate"}
{"X":16611,"RHEA_ID":13326,"DIRECTION":"LR","MASTER_ID":13325,"metacyc":"1.1.1.136-RXN","compounds":"H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-glucosamine => 3 H(+) + 2 NADH + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate"}
{"X":16612,"RHEA_ID":13327,"compounds":"3 H(+) + 2 NADH + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate => H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":16613,"RHEA_ID":23153,"DIRECTION":"LR","MASTER_ID":23152,"ecocyc":"RXN0-5330","metacyc":"RXN0-5330","compounds":"a ubiquinone + H(+) + NADH => a ubiquinol + NAD(+)"}
{"X":16614,"RHEA_ID":13329,"DIRECTION":"UN","MASTER_ID":13329,"ec":"1.3.99.4","compounds":"A + a 3-oxosteroid = a 3-oxo-Delta(1)-steroid + AH2"}
{"X":16615,"RHEA_ID":13330,"DIRECTION":"LR","MASTER_ID":13329,"metacyc":"3-OXOSTEROID-1-DEHYDROGENASE-RXN","compounds":"A + a 3-oxosteroid => a 3-oxo-Delta(1)-steroid + AH2"}
{"X":16616,"RHEA_ID":13331,"compounds":"a 3-oxo-Delta(1)-steroid + AH2 => A + a 3-oxosteroid"}
{"X":16617,"RHEA_ID":23157,"DIRECTION":"LR","MASTER_ID":23156,"metacyc":"RXN-1403","compounds":"(E)-(indol-3-yl)acetaldehyde oxime => (indol-3-yl)acetonitrile + H2O"}
{"X":16618,"RHEA_ID":13333,"DIRECTION":"UN","MASTER_ID":13333,"ec":"3.1.3.54","compounds":"beta-D-fructose 2,6-bisphosphate + H2O = beta-D-fructose 2-phosphate + phosphate"}
{"X":16619,"RHEA_ID":13334,"DIRECTION":"LR","MASTER_ID":13333,"metacyc":"3.1.3.54-RXN","compounds":"beta-D-fructose 2,6-bisphosphate + H2O => beta-D-fructose 2-phosphate + phosphate"}
{"X":16620,"RHEA_ID":13335,"compounds":"beta-D-fructose 2-phosphate + phosphate => beta-D-fructose 2,6-bisphosphate + H2O"}
{"X":16621,"RHEA_ID":23161,"compounds":"L-rhamnopyranose => L-rhamnulose"}
{"X":16622,"RHEA_ID":13337,"DIRECTION":"UN","MASTER_ID":13337,"ec":"3.1.1.19","compounds":"D-glucurono-6,2-lactone + H2O = D-glucuronate + H(+)"}
{"X":16623,"RHEA_ID":13338,"DIRECTION":"LR","MASTER_ID":13337,"metacyc":"URONOLACTONASE-RXN","compounds":"D-glucurono-6,2-lactone + H2O => D-glucuronate + H(+)"}
{"X":16624,"RHEA_ID":13339,"compounds":"D-glucuronate + H(+) => D-glucurono-6,2-lactone + H2O"}
{"X":16625,"RHEA_ID":23165,"DIRECTION":"LR","MASTER_ID":23164,"metacyc":"2.4.1.237-RXN","compounds":"a 7-O-hydroxy-flavonol + UDP-alpha-D-glucose => a flavonol 7-O-beta-D-glucoside + H(+) + UDP"}
{"X":16626,"RHEA_ID":13341,"DIRECTION":"UN","MASTER_ID":13341,"ec":"2.1.1.350","compounds":"a menaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine = 5'-deoxyadenosine + an 8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine"}
{"X":16627,"RHEA_ID":13342,"DIRECTION":"LR","MASTER_ID":13341,"metacyc":"RXN-18515","compounds":"a menaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine => 5'-deoxyadenosine + an 8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine"}
{"X":16628,"RHEA_ID":13343,"compounds":"5'-deoxyadenosine + an 8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine => a menaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine"}
{"X":16629,"RHEA_ID":23169,"compounds":"coformycin + NADP(+) => 8-oxocoformycin + H(+) + NADPH"}
{"X":16630,"RHEA_ID":13345,"DIRECTION":"UN","MASTER_ID":13345,"ec":"2.5.1.58","compounds":"(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein]"}
{"X":16631,"RHEA_ID":13346,"compounds":"(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] => diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein]"}
{"X":16632,"RHEA_ID":13347,"compounds":"diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein] => (2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein]"}
{"X":16633,"RHEA_ID":13349,"DIRECTION":"UN","MASTER_ID":13349,"ec":"2.1.1.141","compounds":"jasmonate + S-adenosyl-L-methionine = methyl (-)-jasmonate + S-adenosyl-L-homocysteine"}
{"X":16634,"RHEA_ID":13350,"DIRECTION":"LR","MASTER_ID":13349,"metacyc":"RXN1F-28","compounds":"jasmonate + S-adenosyl-L-methionine => methyl (-)-jasmonate + S-adenosyl-L-homocysteine"}
{"X":16635,"RHEA_ID":13351,"compounds":"methyl (-)-jasmonate + S-adenosyl-L-homocysteine => jasmonate + S-adenosyl-L-methionine"}
{"X":16636,"RHEA_ID":23177,"DIRECTION":"LR","MASTER_ID":23176,"ecocyc":"ACETATE--COA-LIGASE-RXN","reactome":"R-HSA-71735.1","compounds":"acetate + ATP + CoA => acetyl-CoA + AMP + diphosphate"}
{"X":16637,"RHEA_ID":13353,"DIRECTION":"UN","MASTER_ID":13353,"ec":"2.7.8.14","compounds":"4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol = 4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+)"}
{"X":16638,"RHEA_ID":13354,"DIRECTION":"LR","MASTER_ID":13353,"metacyc":"RXN-18008","compounds":"4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol => 4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+)"}
{"X":16639,"RHEA_ID":13355,"compounds":"4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+) => 4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol"}
{"X":16640,"RHEA_ID":43733,"compounds":"a triacyl-sn-glycerol + H2O => 1,3-diacyl-sn-glycerol + a fatty acid + H(+)"}
{"X":16641,"RHEA_ID":13357,"DIRECTION":"UN","MASTER_ID":13357,"ec":"1.1.1.59","compounds":"3-hydroxypropanoate + NAD(+) = 3-oxopropanoate + H(+) + NADH"}
{"X":16642,"RHEA_ID":13358,"DIRECTION":"LR","MASTER_ID":13357,"metacyc":"3-HYDROXYPROPIONATE-DEHYDROGENASE-RXN","compounds":"3-hydroxypropanoate + NAD(+) => 3-oxopropanoate + H(+) + NADH"}
{"X":16643,"RHEA_ID":13359,"compounds":"3-oxopropanoate + H(+) + NADH => 3-hydroxypropanoate + NAD(+)"}
{"X":16644,"RHEA_ID":13361,"DIRECTION":"UN","MASTER_ID":13361,"ec":"2.7.7.39","compounds":"CTP + H(+) + sn-glycerol 3-phosphate = CDP-glycerol + diphosphate"}
{"X":16645,"RHEA_ID":13362,"DIRECTION":"LR","MASTER_ID":13361,"metacyc":"2.7.7.39-RXN","compounds":"CTP + H(+) + sn-glycerol 3-phosphate => CDP-glycerol + diphosphate"}
{"X":16646,"RHEA_ID":13363,"compounds":"CDP-glycerol + diphosphate => CTP + H(+) + sn-glycerol 3-phosphate"}
{"X":16647,"RHEA_ID":33814,"compounds":"3 2,3-dihydroxybenzoate + 6 ATP + 3 glycine + 3 L-threonine <=> 6 AMP + corynebactin + 6 diphosphate + 3 H(+) + 3 H2O"}
{"X":16648,"RHEA_ID":13369,"DIRECTION":"UN","MASTER_ID":13369,"ec":"4.2.3.27","compounds":"dimethylallyl diphosphate = diphosphate + isoprene"}
{"X":16649,"RHEA_ID":13370,"DIRECTION":"LR","MASTER_ID":13369,"metacyc":"4.2.3.27-RXN","compounds":"dimethylallyl diphosphate => diphosphate + isoprene"}
{"X":16650,"RHEA_ID":13371,"compounds":"diphosphate + isoprene => dimethylallyl diphosphate"}
{"X":16651,"RHEA_ID":13373,"DIRECTION":"UN","MASTER_ID":13373,"ec":"3.5.1.61","metacyc":"MIMOSINASE-RXN","compounds":"H2O + L-mimosine = 3-hydroxy-4H-pyrid-4-one + L-serine"}
{"X":16652,"RHEA_ID":13374,"compounds":"H2O + L-mimosine => 3-hydroxy-4H-pyrid-4-one + L-serine"}
{"X":16653,"RHEA_ID":13375,"compounds":"3-hydroxy-4H-pyrid-4-one + L-serine => H2O + L-mimosine"}
{"X":16654,"RHEA_ID":43749,"compounds":"ATP + CoA + hexacosanoate => AMP + diphosphate + hexacosanoyl-CoA"}
{"X":16655,"RHEA_ID":13377,"DIRECTION":"UN","MASTER_ID":13377,"ec":"2.7.1.10","metacyc":"PHOSPHOGLUCOKINASE-RXN","compounds":"alpha-D-glucose 1-phosphate + ATP = ADP + alpha-D-glucose 1,6-bisphosphate + H(+)"}
{"X":16656,"RHEA_ID":13378,"compounds":"alpha-D-glucose 1-phosphate + ATP => ADP + alpha-D-glucose 1,6-bisphosphate + H(+)"}
{"X":16657,"RHEA_ID":13379,"compounds":"ADP + alpha-D-glucose 1,6-bisphosphate + H(+) => alpha-D-glucose 1-phosphate + ATP"}
{"X":16658,"RHEA_ID":33826,"compounds":"3-(4-hydroxycyclohex-2-en-1-ylidene)pyruvate + H(+) + NADH <=> NAD(+) + tetrahydro-4-hydroxyphenylpyruvate"}
{"X":16659,"RHEA_ID":13381,"DIRECTION":"UN","MASTER_ID":13381,"ec":"2.8.3.8","compounds":"acetate + an acyl-CoA = a fatty acid + acetyl-CoA"}
{"X":16660,"RHEA_ID":13382,"DIRECTION":"LR","MASTER_ID":13381,"ecocyc":"ACECOATRANS-RXN","metacyc":"ACECOATRANS-RXN","compounds":"acetate + an acyl-CoA => a fatty acid + acetyl-CoA"}
{"X":16661,"RHEA_ID":13383,"compounds":"a fatty acid + acetyl-CoA => acetate + an acyl-CoA"}
{"X":16662,"RHEA_ID":13385,"DIRECTION":"UN","MASTER_ID":13385,"ec":"4.1.1.56","compounds":"3-oxododecanoate + H(+) = 2-undecanone + CO2"}
{"X":16663,"RHEA_ID":13386,"DIRECTION":"LR","MASTER_ID":13385,"metacyc":"3-OXOLAURATE-DECARBOXYLASE-RXN","compounds":"3-oxododecanoate + H(+) => 2-undecanone + CO2"}
{"X":16664,"RHEA_ID":13387,"compounds":"2-undecanone + CO2 => 3-oxododecanoate + H(+)"}
{"X":16665,"RHEA_ID":33838,"compounds":"H2O + N-(hexacosanoyl)-(4R)-hydroxysphinganine <=> 4-hydroxysphinganine + hexacosanoate"}
{"X":16666,"RHEA_ID":13389,"DIRECTION":"UN","MASTER_ID":13389,"ec":"1.3.8.6","compounds":"glutaryl-CoA + 2 H(+) + oxidized [electron-transfer flavoprotein] = (2E)-butenoyl-CoA + CO2 + reduced [electron-transfer flavoprotein]"}
{"X":16667,"RHEA_ID":13390,"compounds":"glutaryl-CoA + 2 H(+) + oxidized [electron-transfer flavoprotein] => (2E)-butenoyl-CoA + CO2 + reduced [electron-transfer flavoprotein]"}
{"X":16668,"RHEA_ID":13391,"compounds":"(2E)-butenoyl-CoA + CO2 + reduced [electron-transfer flavoprotein] => glutaryl-CoA + 2 H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":16669,"RHEA_ID":33842,"DIRECTION":"BI","MASTER_ID":33839,"metacyc":"RXN-15425","compounds":"(2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin + H(+) <=> 7-O-geranyl-2-O,3-dimethylflaviolin + diphosphate"}
{"X":16670,"RHEA_ID":13393,"compounds":"diphosphate + nicotinate beta-D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinate"}
{"X":16671,"RHEA_ID":13394,"compounds":"diphosphate + nicotinate beta-D-ribonucleotide => 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinate"}
{"X":16672,"RHEA_ID":13395,"DIRECTION":"RL","MASTER_ID":13393,"ecocyc":"NICOTINATEPRIBOSYLTRANS-RXN","metacyc":"NICOTINATEPRIBOSYLTRANS-RXN","reactome":"R-HSA-197186.3","compounds":"5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinate => diphosphate + nicotinate beta-D-ribonucleotide"}
{"X":16673,"RHEA_ID":13397,"DIRECTION":"UN","MASTER_ID":13397,"ec":"1.2.1.63","compounds":"6-oxohexanoate + H2O + NADP(+) = 2 H(+) + hexanedioate + NADPH"}
{"X":16674,"RHEA_ID":13398,"DIRECTION":"LR","MASTER_ID":13397,"metacyc":"6-OXOHEXANOATE-OXIDATION-RXN","compounds":"6-oxohexanoate + H2O + NADP(+) => 2 H(+) + hexanedioate + NADPH"}
{"X":16675,"RHEA_ID":13399,"compounds":"2 H(+) + hexanedioate + NADPH => 6-oxohexanoate + H2O + NADP(+)"}
{"X":16676,"RHEA_ID":33850,"compounds":"H2O + N-tetracosanoylphytosphingosine <=> 4-hydroxysphinganine + tetracosanoate"}
{"X":16677,"RHEA_ID":13401,"DIRECTION":"UN","MASTER_ID":13401,"ec":"5.2.1.9","metacyc":"FARNESOL-2-ISOMERASE-RXN","compounds":"(2E,6E)-farnesol = (2Z,6E)-farnesol"}
{"X":16678,"RHEA_ID":13402,"compounds":"(2E,6E)-farnesol => (2Z,6E)-farnesol"}
{"X":16679,"RHEA_ID":13403,"compounds":"(2Z,6E)-farnesol => (2E,6E)-farnesol"}
{"X":16680,"RHEA_ID":33854,"compounds":"GDP-alpha-D-mannose + N-tetracosanoylsphinganine-(1D-myo-inositol) <=> GDP + H(+) + Man-beta1-2-Ins-1-P-Cer(d18:0/24:0)"}
{"X":16681,"RHEA_ID":13405,"DIRECTION":"UN","MASTER_ID":13405,"ec":"2.3.1.64","compounds":"4-coumaroyl-CoA + agmatine = CoA + H(+) + N-(4-guanidinobutyl)-4-hydroxycinnamamide"}
{"X":16682,"RHEA_ID":13406,"DIRECTION":"LR","MASTER_ID":13405,"metacyc":"AGMATINE-N4-COUMAROYLTRANSFERASE-RXN","compounds":"4-coumaroyl-CoA + agmatine => CoA + H(+) + N-(4-guanidinobutyl)-4-hydroxycinnamamide"}
{"X":16683,"RHEA_ID":13407,"compounds":"CoA + H(+) + N-(4-guanidinobutyl)-4-hydroxycinnamamide => 4-coumaroyl-CoA + agmatine"}
{"X":16684,"RHEA_ID":33858,"compounds":"an inositol-1-phosphophytoceramide + GDP-alpha-D-mannose <=> a mannosylinositol-1-phosphophytoceramide + GDP + H(+)"}
{"X":16685,"RHEA_ID":13409,"DIRECTION":"UN","MASTER_ID":13409,"ec":"1.7.1.13","compounds":"7-aminomethyl-7-carbaguanine + 2 NADP(+) = 7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH"}
{"X":16686,"RHEA_ID":13410,"compounds":"7-aminomethyl-7-carbaguanine + 2 NADP(+) => 7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH"}
{"X":16687,"RHEA_ID":13411,"DIRECTION":"RL","MASTER_ID":13409,"ecocyc":"RXN0-4022","metacyc":"RXN0-4022","compounds":"7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH => 7-aminomethyl-7-carbaguanine + 2 NADP(+)"}
{"X":16688,"RHEA_ID":43785,"DIRECTION":"LR","MASTER_ID":43784,"metacyc":"RXN-14549","compounds":"adenosine(2142) in 25S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyladenosine(2142) in 25S rRNA + S-adenosyl-L-homocysteine"}
{"X":16689,"RHEA_ID":13413,"DIRECTION":"UN","MASTER_ID":13413,"ec":"2.7.1.118","metacyc":"ADP--THYMIDINE-KINASE-RXN","compounds":"ADP + thymidine = AMP + dTMP + H(+)"}
{"X":16690,"RHEA_ID":13414,"compounds":"ADP + thymidine => AMP + dTMP + H(+)"}
{"X":16691,"RHEA_ID":13415,"compounds":"AMP + dTMP + H(+) => ADP + thymidine"}
{"X":16692,"RHEA_ID":13417,"DIRECTION":"UN","MASTER_ID":13417,"ec":"1.3.1.41","metacyc":"XANTHOMMATIN-REDUCTASE-RXN","compounds":"5,12-dihydroxanthommatin + NAD(+) = H(+) + NADH + xanthommatin"}
{"X":16693,"RHEA_ID":13418,"compounds":"5,12-dihydroxanthommatin + NAD(+) => H(+) + NADH + xanthommatin"}
{"X":16694,"RHEA_ID":13419,"compounds":"H(+) + NADH + xanthommatin => 5,12-dihydroxanthommatin + NAD(+)"}
{"X":16695,"RHEA_ID":13421,"DIRECTION":"UN","MASTER_ID":13421,"ec":"2.5.1.57","compounds":"an N-acyl-D-mannosamine 6-phosphate + H2O + phosphoenolpyruvate = an N-acylneuraminate 9-phosphate + phosphate"}
{"X":16696,"RHEA_ID":13422,"compounds":"an N-acyl-D-mannosamine 6-phosphate + H2O + phosphoenolpyruvate => an N-acylneuraminate 9-phosphate + phosphate"}
{"X":16697,"RHEA_ID":13423,"compounds":"an N-acylneuraminate 9-phosphate + phosphate => an N-acyl-D-mannosamine 6-phosphate + H2O + phosphoenolpyruvate"}
{"X":16698,"RHEA_ID":13425,"DIRECTION":"UN","MASTER_ID":13425,"ec":"3.2.2.10","compounds":"a pyrimidine ribonucleoside 5'-phosphate + H2O = a pyrimidine nucleobase + D-ribose 5-phosphate"}
{"X":16699,"RHEA_ID":13426,"DIRECTION":"LR","MASTER_ID":13425,"metacyc":"3.2.2.10-RXN","compounds":"a pyrimidine ribonucleoside 5'-phosphate + H2O => a pyrimidine nucleobase + D-ribose 5-phosphate"}
{"X":16700,"RHEA_ID":13427,"compounds":"a pyrimidine nucleobase + D-ribose 5-phosphate => a pyrimidine ribonucleoside 5'-phosphate + H2O"}
{"X":16701,"RHEA_ID":33878,"compounds":"cholesteryl (9Z-octadecenoate) + H2O <=> (9Z)-octadecenoate + cholesterol + H(+)"}
{"X":16702,"RHEA_ID":13429,"DIRECTION":"UN","MASTER_ID":13429,"ec":"2.7.7.60","compounds":"2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate"}
{"X":16703,"RHEA_ID":13430,"compounds":"2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) => 4-CDP-2-C-methyl-D-erythritol + diphosphate"}
{"X":16704,"RHEA_ID":13431,"compounds":"4-CDP-2-C-methyl-D-erythritol + diphosphate => 2-C-methyl-D-erythritol 4-phosphate + CTP + H(+)"}
{"X":16705,"RHEA_ID":43809,"compounds":"1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine"}
{"X":16706,"RHEA_ID":13433,"DIRECTION":"UN","MASTER_ID":13433,"ec":"3.5.4.5","compounds":"2'-deoxycytidine + H(+) + H2O = 2'-deoxyuridine + NH4(+)"}
{"X":16707,"RHEA_ID":13434,"DIRECTION":"LR","MASTER_ID":13433,"ecocyc":"CYTIDEAM-RXN","metacyc":"CYTIDEAM-RXN","compounds":"2'-deoxycytidine + H(+) + H2O => 2'-deoxyuridine + NH4(+)"}
{"X":16708,"RHEA_ID":13435,"compounds":"2'-deoxyuridine + NH4(+) => 2'-deoxycytidine + H(+) + H2O"}
{"X":16709,"RHEA_ID":13437,"DIRECTION":"UN","MASTER_ID":13437,"ec":"2.4.1.177","compounds":"trans-cinnamate + UDP-alpha-D-glucose = 1-O-(trans-cinnamoyl)-beta-D-glucose + UDP"}
{"X":16710,"RHEA_ID":13438,"DIRECTION":"LR","MASTER_ID":13437,"metacyc":"CINNAMATE-GLUCOSYLTRANSFERASE-RXN","compounds":"trans-cinnamate + UDP-alpha-D-glucose => 1-O-(trans-cinnamoyl)-beta-D-glucose + UDP"}
{"X":16711,"RHEA_ID":13439,"compounds":"1-O-(trans-cinnamoyl)-beta-D-glucose + UDP => trans-cinnamate + UDP-alpha-D-glucose"}
{"X":16712,"RHEA_ID":43817,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}
{"X":16713,"RHEA_ID":13441,"DIRECTION":"UN","MASTER_ID":13441,"ec":"4.4.1.25","compounds":"H2O + L-cysteate = H(+) + NH4(+) + pyruvate + sulfite"}
{"X":16714,"RHEA_ID":13442,"DIRECTION":"LR","MASTER_ID":13441,"metacyc":"4.4.1.25-RXN","compounds":"H2O + L-cysteate => H(+) + NH4(+) + pyruvate + sulfite"}
{"X":16715,"RHEA_ID":13443,"compounds":"H(+) + NH4(+) + pyruvate + sulfite => H2O + L-cysteate"}
{"X":16716,"RHEA_ID":13445,"DIRECTION":"UN","MASTER_ID":13445,"ec":"3.5.1.92","compounds":"(R)-pantetheine + H2O = (R)-pantothenate + cysteamine"}
{"X":16717,"RHEA_ID":13446,"compounds":"(R)-pantetheine + H2O => (R)-pantothenate + cysteamine"}
{"X":16718,"RHEA_ID":13447,"compounds":"(R)-pantothenate + cysteamine => (R)-pantetheine + H2O"}
{"X":16719,"RHEA_ID":43825,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphate"}
{"X":16720,"RHEA_ID":13449,"compounds":"2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH"}
{"X":16721,"RHEA_ID":13450,"compounds":"2-hydroxyglutarate + NAD(+) => 2-oxoglutarate + H(+) + NADH"}
{"X":16722,"RHEA_ID":13451,"compounds":"2-oxoglutarate + H(+) + NADH => 2-hydroxyglutarate + NAD(+)"}
{"X":16723,"RHEA_ID":13453,"DIRECTION":"UN","MASTER_ID":13453,"ec":"2.8.2.25","compounds":"3'-phosphoadenylyl sulfate + quercetin = adenosine 3',5'-bisphosphate + H(+) + quercetin 3-sulfate"}
{"X":16724,"RHEA_ID":13454,"DIRECTION":"LR","MASTER_ID":13453,"metacyc":"FLAVONOL-3-SULFOTRANSFERASE-RXN","compounds":"3'-phosphoadenylyl sulfate + quercetin => adenosine 3',5'-bisphosphate + H(+) + quercetin 3-sulfate"}
{"X":16725,"RHEA_ID":13455,"compounds":"adenosine 3',5'-bisphosphate + H(+) + quercetin 3-sulfate => 3'-phosphoadenylyl sulfate + quercetin"}
{"X":16726,"RHEA_ID":43833,"compounds":"5-hydroxy-3-[(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA => 5-hydroxy-3-[(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate"}
{"X":16727,"RHEA_ID":13457,"DIRECTION":"UN","MASTER_ID":13457,"ec":"1.2.4.4","compounds":"3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]-(R)-N(6)-lipoyl-L-lysine + H(+) = [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]-(R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysine + CO2"}
{"X":16728,"RHEA_ID":13458,"compounds":"3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]-(R)-N(6)-lipoyl-L-lysine + H(+) => [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]-(R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysine + CO2"}
{"X":16729,"RHEA_ID":13459,"compounds":"[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]-(R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysine + CO2 => 3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]-(R)-N(6)-lipoyl-L-lysine + H(+)"}
{"X":16730,"RHEA_ID":13465,"DIRECTION":"UN","MASTER_ID":13465,"ec":"2.3.1.58","compounds":"(S)-2,3-diaminopropanoate + oxalyl-CoA = CoA + N(3)-oxalyl-L-2,3-diaminopropanoate"}
{"X":16731,"RHEA_ID":13466,"DIRECTION":"LR","MASTER_ID":13465,"metacyc":"2.3.1.58-RXN","compounds":"(S)-2,3-diaminopropanoate + oxalyl-CoA => CoA + N(3)-oxalyl-L-2,3-diaminopropanoate"}
{"X":16732,"RHEA_ID":13467,"compounds":"CoA + N(3)-oxalyl-L-2,3-diaminopropanoate => (S)-2,3-diaminopropanoate + oxalyl-CoA"}
{"X":16733,"RHEA_ID":33914,"compounds":"an N-alkylglycine + H2O + O2 <=> an alkylamine + glyoxylate + H2O2"}
{"X":16734,"RHEA_ID":13469,"DIRECTION":"UN","MASTER_ID":13469,"ec":"1.17.99.4","compounds":"A + H2O + thymine = 5-methylbarbiturate + AH2 + H(+)"}
{"X":16735,"RHEA_ID":13470,"DIRECTION":"LR","MASTER_ID":13469,"metacyc":"RXN-8646","compounds":"A + H2O + thymine => 5-methylbarbiturate + AH2 + H(+)"}
{"X":16736,"RHEA_ID":13471,"compounds":"5-methylbarbiturate + AH2 + H(+) => A + H2O + thymine"}
{"X":16737,"RHEA_ID":43845,"compounds":"(3beta)-hydroxy-cholest-5-en-26-al + NADPH + O2 => (3beta)-hydroxy-cholest-5-en-26-oate + H2O + NADP(+)"}
{"X":16738,"RHEA_ID":13473,"DIRECTION":"UN","MASTER_ID":13473,"ec":"1.4.1.19","metacyc":"N-METHYLALANINE-DEHYDROGENASE-RXN","compounds":"H2O + L-tryptophan + NAD(+) = H(+) + indole-3-pyruvate + NADH + NH4(+)"}
{"X":16739,"RHEA_ID":13474,"compounds":"H2O + L-tryptophan + NAD(+) => H(+) + indole-3-pyruvate + NADH + NH4(+)"}
{"X":16740,"RHEA_ID":13475,"compounds":"H(+) + indole-3-pyruvate + NADH + NH4(+) => H2O + L-tryptophan + NAD(+)"}
{"X":16741,"RHEA_ID":43849,"compounds":"[thioredoxin]-dithiol + arsenate + H(+) => [thioredoxin]-disulfide + arsenite + H2O"}
{"X":16742,"RHEA_ID":13477,"DIRECTION":"UN","MASTER_ID":13477,"ec":"1.4.1.19","metacyc":"N-METHYLALANINE-DEHYDROGENASE-RXN","compounds":"H2O + L-tryptophan + NADP(+) = H(+) + indole-3-pyruvate + NADPH + NH4(+)"}
{"X":16743,"RHEA_ID":13478,"compounds":"H2O + L-tryptophan + NADP(+) => H(+) + indole-3-pyruvate + NADPH + NH4(+)"}
{"X":16744,"RHEA_ID":13479,"compounds":"H(+) + indole-3-pyruvate + NADPH + NH4(+) => H2O + L-tryptophan + NADP(+)"}
{"X":16745,"RHEA_ID":43853,"compounds":"H(+) + malonyl-CoA + triacontanoyl-CoA => 3-oxo-dotriacontanoyl-CoA + CO2 + CoA"}
{"X":16746,"RHEA_ID":13481,"DIRECTION":"UN","MASTER_ID":13481,"ec":"6.1.1.10","compounds":"ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)"}
{"X":16747,"RHEA_ID":13482,"DIRECTION":"LR","MASTER_ID":13481,"ecocyc":"METHIONINE--TRNA-LIGASE-RXN","metacyc":"METHIONINE--TRNA-LIGASE-RXN","compounds":"ATP + L-methionine + tRNA(Met) => AMP + diphosphate + L-methionyl-tRNA(Met)"}
{"X":16748,"RHEA_ID":13483,"compounds":"AMP + diphosphate + L-methionyl-tRNA(Met) => ATP + L-methionine + tRNA(Met)"}
{"X":16749,"RHEA_ID":43857,"compounds":"a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(in) => a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(out)"}
{"X":16750,"RHEA_ID":13485,"DIRECTION":"UN","MASTER_ID":13485,"ec":"2.6.1.75","compounds":"2-oxoglutarate + S-(4-bromophenyl)-L-cysteine = (4-bromophenylsulfanyl)pyruvate + L-glutamate"}
{"X":16751,"RHEA_ID":13486,"compounds":"2-oxoglutarate + S-(4-bromophenyl)-L-cysteine => (4-bromophenylsulfanyl)pyruvate + L-glutamate"}
{"X":16752,"RHEA_ID":13487,"compounds":"(4-bromophenylsulfanyl)pyruvate + L-glutamate => 2-oxoglutarate + S-(4-bromophenyl)-L-cysteine"}
{"X":16753,"RHEA_ID":43861,"compounds":"1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(in) => 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(out)"}
{"X":16754,"RHEA_ID":13489,"DIRECTION":"UN","MASTER_ID":13489,"ec":"1.3.3.8","compounds":"(S)-canadine + H(+) + 2 O2 = berberine + 2 H2O2"}
{"X":16755,"RHEA_ID":13490,"DIRECTION":"LR","MASTER_ID":13489,"metacyc":"TETRAHYDROBERBERINE-OXIDASE-RXN","compounds":"(S)-canadine + H(+) + 2 O2 => berberine + 2 H2O2"}
{"X":16756,"RHEA_ID":13491,"compounds":"berberine + 2 H2O2 => (S)-canadine + H(+) + 2 O2"}
{"X":16757,"RHEA_ID":33938,"compounds":"2 N(omega)-hydroxy-L-arginine + NADH + 2 O2 <=> H(+) + 2 H2O + 2 L-citrulline + NAD(+) + 2 nitric oxide"}
{"X":16758,"RHEA_ID":13493,"DIRECTION":"UN","MASTER_ID":13493,"ec":"1.1.1.86","compounds":"(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH"}
{"X":16759,"RHEA_ID":13494,"compounds":"(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) => (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH"}
{"X":16760,"RHEA_ID":13495,"compounds":"(S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH => (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+)"}
{"X":16761,"RHEA_ID":13496,"DIRECTION":"BI","MASTER_ID":13493,"ecocyc":"ACETOOHBUTREDUCTOISOM-RXN","metacyc":"ACETOOHBUTREDUCTOISOM-RXN","compounds":"(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) <=> (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH"}
{"X":16762,"RHEA_ID":13497,"DIRECTION":"UN","MASTER_ID":13497,"ec":"2.7.1.92","compounds":"5-dehydro-2-deoxy-D-gluconate + ATP = 6-phospho-5-dehydro-2-deoxy-D-gluconate + ADP + H(+)"}
{"X":16763,"RHEA_ID":13498,"DIRECTION":"LR","MASTER_ID":13497,"metacyc":"5-DEHYDRO-2-DEOXYGLUCONOKINASE-RXN","compounds":"5-dehydro-2-deoxy-D-gluconate + ATP => 6-phospho-5-dehydro-2-deoxy-D-gluconate + ADP + H(+)"}
{"X":16764,"RHEA_ID":13499,"compounds":"6-phospho-5-dehydro-2-deoxy-D-gluconate + ADP + H(+) => 5-dehydro-2-deoxy-D-gluconate + ATP"}
{"X":16765,"RHEA_ID":43873,"compounds":"3-oxochol-4-en-22-oate + ATP + CoA => 3-oxochol-4-en-22-oyl-CoA + AMP + diphosphate"}
{"X":16766,"RHEA_ID":13501,"DIRECTION":"UN","MASTER_ID":13501,"ec":"6.3.4.14","compounds":"ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] = ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate"}
{"X":16767,"RHEA_ID":13502,"DIRECTION":"LR","MASTER_ID":13501,"ecocyc":"BIOTIN-CARBOXYL-RXN","metacyc":"BIOTIN-CARBOXYL-RXN","compounds":"ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] => ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate"}
{"X":16768,"RHEA_ID":13503,"compounds":"ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate => ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein]"}
{"X":16769,"RHEA_ID":43877,"compounds":"3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oate + ATP + CoA => 3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oyl-CoA + AMP + diphosphate"}
{"X":16770,"RHEA_ID":13505,"compounds":"choline + O2 = betaine aldehyde + H2O2"}
{"X":16771,"RHEA_ID":13506,"DIRECTION":"LR","MASTER_ID":13505,"metacyc":"CHOLINE-OXIDASE-RXN","compounds":"choline + O2 => betaine aldehyde + H2O2"}
{"X":16772,"RHEA_ID":13507,"compounds":"betaine aldehyde + H2O2 => choline + O2"}
{"X":16773,"RHEA_ID":43881,"compounds":"3beta-hydroxy-5-cholestenoate + ATP + CoA => 3beta-hydroxy-5-cholestenoyl-CoA + AMP + diphosphate"}
{"X":16774,"RHEA_ID":13509,"DIRECTION":"UN","MASTER_ID":13509,"ec":"2.7.7.23","compounds":"H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":16775,"RHEA_ID":13510,"DIRECTION":"LR","MASTER_ID":13509,"ecocyc":"NAG1P-URIDYLTRANS-RXN","metacyc":"NAG1P-URIDYLTRANS-RXN","compounds":"H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP => diphosphate + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":16776,"RHEA_ID":13511,"compounds":"diphosphate + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP"}
{"X":16777,"RHEA_ID":23327,"compounds":"2'-phospho-[ligated tRNA] + NAD(+) <=> ADP-D-ribose 1'',2''-cyclic phosphate + mature tRNA + nicotinamide"}
{"X":16778,"RHEA_ID":13513,"DIRECTION":"UN","MASTER_ID":13513,"ec":"1.3.1.14","compounds":"(S)-dihydroorotate + NAD(+) = H(+) + NADH + orotate"}
{"X":16779,"RHEA_ID":13514,"compounds":"(S)-dihydroorotate + NAD(+) => H(+) + NADH + orotate"}
{"X":16780,"RHEA_ID":13515,"compounds":"H(+) + NADH + orotate => (S)-dihydroorotate + NAD(+)"}
{"X":16781,"RHEA_ID":13517,"DIRECTION":"UN","MASTER_ID":13517,"ec":"2.7.4.9","compounds":"ATP + dTMP = ADP + dTDP"}
{"X":16782,"RHEA_ID":13517,"DIRECTION":"UN","MASTER_ID":13517,"ec":"2.7.4.12","compounds":"ATP + dTMP = ADP + dTDP"}
{"X":16783,"RHEA_ID":13518,"DIRECTION":"LR","MASTER_ID":13517,"ecocyc":"DTMPKI-RXN","metacyc":"DTMPKI-RXN","reactome":"R-HSA-73635.4","compounds":"ATP + dTMP => ADP + dTDP"}
{"X":16784,"RHEA_ID":13519,"DIRECTION":"RL","MASTER_ID":13517,"reactome":"R-HSA-75126.4","compounds":"ADP + dTDP => ATP + dTMP"}
{"X":16785,"RHEA_ID":23336,"DIRECTION":"UN","MASTER_ID":23336,"ec":"1.11.1.8","compounds":"2 H(+) + H2O2 + 2 iodide = diiodine + 2 H2O"}
{"X":16786,"RHEA_ID":13521,"DIRECTION":"UN","MASTER_ID":13521,"ec":"1.1.2.4","compounds":"(R)-lactate + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H(+) + pyruvate"}
{"X":16787,"RHEA_ID":13522,"DIRECTION":"LR","MASTER_ID":13521,"metacyc":"D-LACTATE-DEHYDROGENASE-CYTOCHROME-RXN","compounds":"(R)-lactate + 2 [Fe(III)cytochrome c] => 2 [Fe(II)cytochrome c] + 2 H(+) + pyruvate"}
{"X":16788,"RHEA_ID":13523,"compounds":"2 [Fe(II)cytochrome c] + 2 H(+) + pyruvate => (R)-lactate + 2 [Fe(III)cytochrome c]"}
{"X":16789,"RHEA_ID":13525,"DIRECTION":"UN","MASTER_ID":13525,"ec":"1.14.15.1","compounds":"(1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin] = (1R,4R,5R)-5-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin]"}
{"X":16790,"RHEA_ID":13526,"DIRECTION":"LR","MASTER_ID":13525,"metacyc":"R541-RXN","compounds":"(1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin] => (1R,4R,5R)-5-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin]"}
{"X":16791,"RHEA_ID":13527,"compounds":"(1R,4R,5R)-5-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin] => (1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin]"}
{"X":16792,"RHEA_ID":23344,"DIRECTION":"UN","MASTER_ID":23344,"ec":"3.2.2.1","compounds":"a purine D-ribonucleoside + H2O = a purine nucleobase + D-ribose"}
{"X":16793,"RHEA_ID":13529,"DIRECTION":"UN","MASTER_ID":13529,"ec":"4.2.1.34","compounds":"(3S)-citramalate = H2O + mesaconate"}
{"X":16794,"RHEA_ID":13530,"compounds":"(3S)-citramalate => H2O + mesaconate"}
{"X":16795,"RHEA_ID":13531,"compounds":"H2O + mesaconate => (3S)-citramalate"}
{"X":16796,"RHEA_ID":23348,"DIRECTION":"UN","MASTER_ID":23348,"ec":"4.1.1.44","compounds":"(R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H(+) = (4,5-dihydro-5-oxofuran-2-yl)-acetate + CO2"}
{"X":16797,"RHEA_ID":13533,"compounds":"H2O + medicarpin + NADP(+) = (3R)-vestitone + H(+) + NADPH"}
{"X":16798,"RHEA_ID":13534,"compounds":"H2O + medicarpin + NADP(+) => (3R)-vestitone + H(+) + NADPH"}
{"X":16799,"RHEA_ID":13535,"compounds":"(3R)-vestitone + H(+) + NADPH => H2O + medicarpin + NADP(+)"}
{"X":16800,"RHEA_ID":23352,"DIRECTION":"UN","MASTER_ID":23352,"ec":"2.6.1.19","compounds":"2-oxoglutarate + 4-aminobutanoate = L-glutamate + succinate semialdehyde"}
{"X":16801,"RHEA_ID":13537,"DIRECTION":"UN","MASTER_ID":13537,"ec":"2.4.1.217","compounds":"(2R)-3-phosphoglycerate + GDP-alpha-D-mannose = 2-O-(alpha-D-mannosyl)-3-phosphoglycerate + GDP + H(+)"}
{"X":16802,"RHEA_ID":13538,"DIRECTION":"LR","MASTER_ID":13537,"metacyc":"2.4.1.217-RXN","compounds":"(2R)-3-phosphoglycerate + GDP-alpha-D-mannose => 2-O-(alpha-D-mannosyl)-3-phosphoglycerate + GDP + H(+)"}
{"X":16803,"RHEA_ID":13539,"compounds":"2-O-(alpha-D-mannosyl)-3-phosphoglycerate + GDP + H(+) => (2R)-3-phosphoglycerate + GDP-alpha-D-mannose"}
{"X":16804,"RHEA_ID":23356,"DIRECTION":"UN","MASTER_ID":23356,"ec":"2.7.11.14","compounds":"[rhodopsin]-L-serine + ATP = [rhodopsin]-O-phospho-L-serine + ADP + H(+)"}
{"X":16805,"RHEA_ID":13541,"compounds":"H2O + tetrathionate = H(+) + sulfate + sulfur + thiosulfate"}
{"X":16806,"RHEA_ID":13542,"DIRECTION":"LR","MASTER_ID":13541,"metacyc":"RXN-10852","compounds":"H2O + tetrathionate => H(+) + sulfate + sulfur + thiosulfate"}
{"X":16807,"RHEA_ID":13543,"compounds":"H(+) + sulfate + sulfur + thiosulfate => H2O + tetrathionate"}
{"X":16808,"RHEA_ID":13544,"compounds":"H2O + tetrathionate <=> H(+) + sulfate + sulfur + thiosulfate"}
{"X":16809,"RHEA_ID":13545,"DIRECTION":"UN","MASTER_ID":13545,"ec":"1.14.14.58","compounds":"(6E,10E)-geranyllinalool + O2 + reduced [NADPH--hemoprotein reductase] = (3E,7E)-4,8,12-trimethyltrideca 1,3,7,11-tetraene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":16810,"RHEA_ID":13546,"DIRECTION":"LR","MASTER_ID":13545,"metacyc":"RXN-8620","compounds":"(6E,10E)-geranyllinalool + O2 + reduced [NADPH--hemoprotein reductase] => (3E,7E)-4,8,12-trimethyltrideca 1,3,7,11-tetraene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":16811,"RHEA_ID":13547,"compounds":"(3E,7E)-4,8,12-trimethyltrideca 1,3,7,11-tetraene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (6E,10E)-geranyllinalool + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":16812,"RHEA_ID":23368,"DIRECTION":"UN","MASTER_ID":23368,"ec":"4.1.1.7","compounds":"H(+) + phenylglyoxylate = benzaldehyde + CO2"}
{"X":16813,"RHEA_ID":13549,"DIRECTION":"UN","MASTER_ID":13549,"ec":"2.7.7.30","compounds":"beta-L-fucose 1-phosphate + GTP + H(+) = diphosphate + GDP-beta-L-fucose"}
{"X":16814,"RHEA_ID":13550,"DIRECTION":"LR","MASTER_ID":13549,"metacyc":"2.7.7.30-RXN","compounds":"beta-L-fucose 1-phosphate + GTP + H(+) => diphosphate + GDP-beta-L-fucose"}
{"X":16815,"RHEA_ID":13551,"compounds":"diphosphate + GDP-beta-L-fucose => beta-L-fucose 1-phosphate + GTP + H(+)"}
{"X":16816,"RHEA_ID":23372,"DIRECTION":"UN","MASTER_ID":23372,"ec":"6.3.2.8","compounds":"ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine"}
{"X":16817,"RHEA_ID":13553,"DIRECTION":"UN","MASTER_ID":13553,"ec":"2.7.1.6","compounds":"alpha-D-galactose + ATP = ADP + alpha-D-galactose 1-phosphate + H(+)"}
{"X":16818,"RHEA_ID":13554,"DIRECTION":"LR","MASTER_ID":13553,"ecocyc":"GALACTOKIN-RXN","compounds":"alpha-D-galactose + ATP => ADP + alpha-D-galactose 1-phosphate + H(+)"}
{"X":16819,"RHEA_ID":13555,"compounds":"ADP + alpha-D-galactose 1-phosphate + H(+) => alpha-D-galactose + ATP"}
{"X":16820,"RHEA_ID":23376,"DIRECTION":"UN","MASTER_ID":23376,"ec":"1.1.1.129","metacyc":"L-THREONATE-3-DEHYDROGENASE-RXN","compounds":"L-threonate + NAD(+) = 3-dehydro-D-erythronate + H(+) + NADH"}
{"X":16821,"RHEA_ID":13557,"DIRECTION":"UN","MASTER_ID":13557,"ec":"6.3.2.3","compounds":"ATP + glycine + L-gamma-glutamyl-L-cysteine = ADP + glutathione + H(+) + phosphate"}
{"X":16822,"RHEA_ID":13558,"DIRECTION":"LR","MASTER_ID":13557,"ecocyc":"GLUTATHIONE-SYN-RXN","macie":"M0199","metacyc":"GLUTATHIONE-SYN-RXN","reactome":"R-HSA-174394.4","compounds":"ATP + glycine + L-gamma-glutamyl-L-cysteine => ADP + glutathione + H(+) + phosphate"}
{"X":16823,"RHEA_ID":13559,"compounds":"ADP + glutathione + H(+) + phosphate => ATP + glycine + L-gamma-glutamyl-L-cysteine"}
{"X":16824,"RHEA_ID":23380,"DIRECTION":"UN","MASTER_ID":23380,"ec":"2.4.1.141","compounds":"N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N,N'-diacetylchitobiosyl diphosphodolichol + UDP"}
{"X":16825,"RHEA_ID":13561,"DIRECTION":"UN","MASTER_ID":13561,"ec":"1.4.1.16","compounds":"H2O + meso-2,6-diaminoheptanedioate + NADP(+) = (S)-2-amino-6-oxoheptanedioate + H(+) + NADPH + NH4(+)"}
{"X":16826,"RHEA_ID":13562,"compounds":"H2O + meso-2,6-diaminoheptanedioate + NADP(+) => (S)-2-amino-6-oxoheptanedioate + H(+) + NADPH + NH4(+)"}
{"X":16827,"RHEA_ID":13563,"compounds":"(S)-2-amino-6-oxoheptanedioate + H(+) + NADPH + NH4(+) => H2O + meso-2,6-diaminoheptanedioate + NADP(+)"}
{"X":16828,"RHEA_ID":23384,"DIRECTION":"UN","MASTER_ID":23384,"ec":"5.1.3.11","compounds":"D-cellobiose = beta-D-glucosyl-(1->4)-D-mannopyranose"}
{"X":16829,"RHEA_ID":13565,"DIRECTION":"UN","MASTER_ID":13565,"ec":"2.7.8.12","compounds":"4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-glycerol = 4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n CMP + n H(+)"}
{"X":16830,"RHEA_ID":13566,"DIRECTION":"LR","MASTER_ID":13565,"metacyc":"TEICHOICSYN4-RXN","compounds":"4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-glycerol => 4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n CMP + n H(+)"}
{"X":16831,"RHEA_ID":13567,"compounds":"4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n CMP + n H(+) => 4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-glycerol"}
{"X":16832,"RHEA_ID":23388,"DIRECTION":"UN","MASTER_ID":23388,"ec":"2.7.1.119","compounds":"ATP + hygromycin B = 7''-O-phosphohygromycin B + ADP + H(+)"}
{"X":16833,"RHEA_ID":13569,"DIRECTION":"UN","MASTER_ID":13569,"ec":"2.4.1.165","compounds":"ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = beta-D-GalNAc-(1->4)-alpha-Neu5Ac-(2->3)-alpha-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer + H(+) + UDP"}
{"X":16834,"RHEA_ID":13570,"DIRECTION":"LR","MASTER_ID":13569,"metacyc":"2.4.1.165-RXN","compounds":"ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => beta-D-GalNAc-(1->4)-alpha-Neu5Ac-(2->3)-alpha-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer + H(+) + UDP"}
{"X":16835,"RHEA_ID":13571,"compounds":"beta-D-GalNAc-(1->4)-alpha-Neu5Ac-(2->3)-alpha-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer + H(+) + UDP => ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine"}
{"X":16836,"RHEA_ID":23392,"compounds":"(nucleoside 5'-monophosphate)n + (n-1) H2O = n a ribonucleoside 5'-phosphate + n H(+)"}
{"X":16837,"RHEA_ID":13573,"DIRECTION":"UN","MASTER_ID":13573,"ec":"2.4.1.43","compounds":"[(1->4)-alpha-D-galacturonosyl](n) + UDP-alpha-D-galacturonate = [(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP"}
{"X":16838,"RHEA_ID":13574,"DIRECTION":"LR","MASTER_ID":13573,"metacyc":"2.4.1.43-RXN","compounds":"[(1->4)-alpha-D-galacturonosyl](n) + UDP-alpha-D-galacturonate => [(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP"}
{"X":16839,"RHEA_ID":13575,"compounds":"[(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP => [(1->4)-alpha-D-galacturonosyl](n) + UDP-alpha-D-galacturonate"}
{"X":16840,"RHEA_ID":23395,"compounds":"(nucleoside 5'-monophosphate)n + (n-1) H2O <=> n a ribonucleoside 5'-phosphate + n H(+)"}
{"X":16841,"RHEA_ID":13577,"DIRECTION":"UN","MASTER_ID":13577,"ec":"3.1.1.50","compounds":"a wax ester + H2O = a long chain fatty alcohol + a long-chain fatty acid + H(+)"}
{"X":16842,"RHEA_ID":13578,"DIRECTION":"LR","MASTER_ID":13577,"metacyc":"WAX-ESTER-HYDROLASE-RXN","compounds":"a wax ester + H2O => a long chain fatty alcohol + a long-chain fatty acid + H(+)"}
{"X":16843,"RHEA_ID":13579,"compounds":"a long chain fatty alcohol + a long-chain fatty acid + H(+) => a wax ester + H2O"}
{"X":16844,"RHEA_ID":13581,"DIRECTION":"UN","MASTER_ID":13581,"ec":"2.7.8.17","compounds":"N(4)-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UMP"}
{"X":16845,"RHEA_ID":13582,"DIRECTION":"LR","MASTER_ID":13581,"metacyc":"2.7.8.17-RXN","compounds":"N(4)-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UMP"}
{"X":16846,"RHEA_ID":13583,"compounds":"H(+) + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UMP => N(4)-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":16847,"RHEA_ID":34031,"DIRECTION":"UN","MASTER_ID":34031,"ec":"3.5.1.112","compounds":"2'-N-acetylparomamine + H2O = acetate + paromamine"}
{"X":16848,"RHEA_ID":13585,"DIRECTION":"UN","MASTER_ID":13585,"ec":"2.7.2.7","compounds":"ATP + butanoate = ADP + butanoyl phosphate"}
{"X":16849,"RHEA_ID":13586,"compounds":"ATP + butanoate => ADP + butanoyl phosphate"}
{"X":16850,"RHEA_ID":13587,"compounds":"ADP + butanoyl phosphate => ATP + butanoate"}
{"X":16851,"RHEA_ID":34035,"DIRECTION":"UN","MASTER_ID":34035,"ec":"1.1.3.43","compounds":"O2 + paromamine = 6'-oxoparomamine + H2O2"}
{"X":16852,"RHEA_ID":13589,"DIRECTION":"UN","MASTER_ID":13589,"ec":"6.4.1.4","compounds":"3-methylbut-2-enoyl-CoA + ATP + hydrogencarbonate = ADP + H(+) + phosphate + trans-3-methylglutaconyl-CoA"}
{"X":16853,"RHEA_ID":13590,"DIRECTION":"LR","MASTER_ID":13589,"metacyc":"METHYLCROTONYL-COA-CARBOXYLASE-RXN","reactome":"R-HSA-70773.4","compounds":"3-methylbut-2-enoyl-CoA + ATP + hydrogencarbonate => ADP + H(+) + phosphate + trans-3-methylglutaconyl-CoA"}
{"X":16854,"RHEA_ID":13591,"compounds":"ADP + H(+) + phosphate + trans-3-methylglutaconyl-CoA => 3-methylbut-2-enoyl-CoA + ATP + hydrogencarbonate"}
{"X":16855,"RHEA_ID":34039,"DIRECTION":"UN","MASTER_ID":34039,"ec":"2.6.1.93","compounds":"2-oxoglutarate + neamine = 6'-oxoparomamine + L-glutamate"}
{"X":16856,"RHEA_ID":13593,"compounds":"allantoate + 2 H(+) + H2O = CO2 + NH4(+) + ureidoglycine"}
{"X":16857,"RHEA_ID":13594,"DIRECTION":"LR","MASTER_ID":13593,"ecocyc":"ALLANTOATE-DEIMINASE-RXN","metacyc":"ALLANTOATE-DEIMINASE-RXN","compounds":"allantoate + 2 H(+) + H2O => CO2 + NH4(+) + ureidoglycine"}
{"X":16858,"RHEA_ID":13595,"compounds":"CO2 + NH4(+) + ureidoglycine => allantoate + 2 H(+) + H2O"}
{"X":16859,"RHEA_ID":13597,"DIRECTION":"UN","MASTER_ID":13597,"ec":"3.5.3.20","metacyc":"DIGUANIDINOBUTANASE-RXN","compounds":"1,4-diguanidinobutane + H2O = agmatine + urea"}
{"X":16860,"RHEA_ID":13598,"compounds":"1,4-diguanidinobutane + H2O => agmatine + urea"}
{"X":16861,"RHEA_ID":13599,"compounds":"agmatine + urea => 1,4-diguanidinobutane + H2O"}
{"X":16862,"RHEA_ID":34047,"DIRECTION":"UN","MASTER_ID":34047,"ec":"1.1.3.44","compounds":"6'''-deamino-6'''-hydroxyneomycin C + O2 = 6'''-deamino-6'''-oxoneomycin C + H2O2"}
{"X":16863,"RHEA_ID":13601,"DIRECTION":"UN","MASTER_ID":13601,"ec":"1.1.1.104","metacyc":"4-OXOPROLINE-REDUCTASE-RXN","compounds":"4-hydroxy-L-proline + NAD(+) = 4-oxo-L-proline + H(+) + NADH"}
{"X":16864,"RHEA_ID":13602,"compounds":"4-hydroxy-L-proline + NAD(+) => 4-oxo-L-proline + H(+) + NADH"}
{"X":16865,"RHEA_ID":13603,"compounds":"4-oxo-L-proline + H(+) + NADH => 4-hydroxy-L-proline + NAD(+)"}
{"X":16866,"RHEA_ID":13605,"compounds":"2 L-ascorbate + O2 = 2 H2O + 2 L-dehydroascorbate"}
{"X":16867,"RHEA_ID":13606,"compounds":"2 L-ascorbate + O2 => 2 H2O + 2 L-dehydroascorbate"}
{"X":16868,"RHEA_ID":13607,"compounds":"2 H2O + 2 L-dehydroascorbate => 2 L-ascorbate + O2"}
{"X":16869,"RHEA_ID":34055,"DIRECTION":"UN","MASTER_ID":34055,"ec":"1.5.1.44","compounds":"festuclavine + NAD(+) = 6,8-dimethyl-6,7-didehydroergoline + H(+) + NADH"}
{"X":16870,"RHEA_ID":13609,"DIRECTION":"UN","MASTER_ID":13609,"ec":"2.7.1.150","compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)"}
{"X":16871,"RHEA_ID":13610,"DIRECTION":"LR","MASTER_ID":13609,"metacyc":"2.7.1.150-RXN","compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)"}
{"X":16872,"RHEA_ID":13611,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP"}
{"X":16873,"RHEA_ID":13613,"DIRECTION":"UN","MASTER_ID":13613,"ec":"2.7.1.90","compounds":"beta-D-fructose 6-phosphate + diphosphate = beta-D-fructose 1,6-bisphosphate + H(+) + phosphate"}
{"X":16874,"RHEA_ID":13614,"compounds":"beta-D-fructose 6-phosphate + diphosphate => beta-D-fructose 1,6-bisphosphate + H(+) + phosphate"}
{"X":16875,"RHEA_ID":13615,"compounds":"beta-D-fructose 1,6-bisphosphate + H(+) + phosphate => beta-D-fructose 6-phosphate + diphosphate"}
{"X":16876,"RHEA_ID":34063,"DIRECTION":"UN","MASTER_ID":34063,"ec":"2.4.1.284","compounds":"2-deoxystreptamine + UDP-alpha-D-glucose = 2'-deamino-2'-hydroxyparomamine + H(+) + UDP"}
{"X":16877,"RHEA_ID":13617,"DIRECTION":"UN","MASTER_ID":13617,"ec":"3.2.2.9","compounds":"H2O + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-D-ribose"}
{"X":16878,"RHEA_ID":13617,"DIRECTION":"UN","MASTER_ID":13617,"ec":"3.2.2.16","compounds":"H2O + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-D-ribose"}
{"X":16879,"RHEA_ID":13618,"DIRECTION":"LR","MASTER_ID":13617,"ecocyc":"METHYLTHIOADENOSINE-NUCLEOSIDASE-RXN","metacyc":"METHYLTHIOADENOSINE-NUCLEOSIDASE-RXN","compounds":"H2O + S-methyl-5'-thioadenosine => adenine + S-methyl-5-thio-D-ribose"}
{"X":16880,"RHEA_ID":13619,"compounds":"adenine + S-methyl-5-thio-D-ribose => H2O + S-methyl-5'-thioadenosine"}
{"X":16881,"RHEA_ID":23440,"DIRECTION":"UN","MASTER_ID":23440,"ec":"3.8.1.6","compounds":"4-chlorobenzoate + H2O = 4-hydroxybenzoate + chloride + H(+)"}
{"X":16882,"RHEA_ID":13621,"DIRECTION":"UN","MASTER_ID":13621,"ec":"5.4.99.15","compounds":"4-[(1->4)-alpha-D-glucosyl](n-1)-D-glucose = 1-[(1->4)-alpha-D-glucosyl](n-1)-alpha-D-glucose"}
{"X":16883,"RHEA_ID":13622,"DIRECTION":"LR","MASTER_ID":13621,"metacyc":"5.4.99.15-RXN","compounds":"4-[(1->4)-alpha-D-glucosyl](n-1)-D-glucose => 1-[(1->4)-alpha-D-glucosyl](n-1)-alpha-D-glucose"}
{"X":16884,"RHEA_ID":13623,"compounds":"1-[(1->4)-alpha-D-glucosyl](n-1)-alpha-D-glucose => 4-[(1->4)-alpha-D-glucosyl](n-1)-D-glucose"}
{"X":16885,"RHEA_ID":13625,"DIRECTION":"UN","MASTER_ID":13625,"ec":"1.5.99.12","compounds":"A + H2O + N(6)-dimethylallyladenine = 3-methyl-2-butenal + adenine + AH2"}
{"X":16886,"RHEA_ID":13626,"compounds":"A + H2O + N(6)-dimethylallyladenine => 3-methyl-2-butenal + adenine + AH2"}
{"X":16887,"RHEA_ID":13627,"compounds":"3-methyl-2-butenal + adenine + AH2 => A + H2O + N(6)-dimethylallyladenine"}
{"X":16888,"RHEA_ID":13629,"DIRECTION":"UN","MASTER_ID":13629,"ec":"1.1.1.243","compounds":"(1S,5R)-carveol + NADP(+) = (R)-carvone + H(+) + NADPH"}
{"X":16889,"RHEA_ID":13630,"DIRECTION":"LR","MASTER_ID":13629,"metacyc":"CARVEOL-DEHYDROGENASE-RXN","compounds":"(1S,5R)-carveol + NADP(+) => (R)-carvone + H(+) + NADPH"}
{"X":16890,"RHEA_ID":13631,"compounds":"(R)-carvone + H(+) + NADPH => (1S,5R)-carveol + NADP(+)"}
{"X":16891,"RHEA_ID":34080,"compounds":"1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + ADP + H(+) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + ATP"}
{"X":16892,"RHEA_ID":13633,"DIRECTION":"UN","MASTER_ID":13633,"ec":"6.3.1.11","compounds":"ATP + L-glutamate + putrescine = ADP + gamma-L-glutamylputrescine + H(+) + phosphate"}
{"X":16893,"RHEA_ID":13634,"DIRECTION":"LR","MASTER_ID":13633,"ecocyc":"RXN0-3901","metacyc":"RXN0-3901","compounds":"ATP + L-glutamate + putrescine => ADP + gamma-L-glutamylputrescine + H(+) + phosphate"}
{"X":16894,"RHEA_ID":13635,"compounds":"ADP + gamma-L-glutamylputrescine + H(+) + phosphate => ATP + L-glutamate + putrescine"}
{"X":16895,"RHEA_ID":23454,"compounds":"ADP + dAMP + H(+) => 2'-deoxyadenosine + ATP"}
{"X":16896,"RHEA_ID":13637,"DIRECTION":"UN","MASTER_ID":13637,"ec":"1.14.13.25","compounds":"H(+) + methane + NADH + O2 = H2O + methanol + NAD(+)"}
{"X":16897,"RHEA_ID":13638,"DIRECTION":"LR","MASTER_ID":13637,"metacyc":"METHANE-MONOOXYGENASE-RXN","compounds":"H(+) + methane + NADH + O2 => H2O + methanol + NAD(+)"}
{"X":16898,"RHEA_ID":13639,"compounds":"H2O + methanol + NAD(+) => H(+) + methane + NADH + O2"}
{"X":16899,"RHEA_ID":13641,"DIRECTION":"UN","MASTER_ID":13641,"ec":"1.14.13.25","compounds":"H(+) + methane + NADPH + O2 = H2O + methanol + NADP(+)"}
{"X":16900,"RHEA_ID":13642,"DIRECTION":"LR","MASTER_ID":13641,"metacyc":"METHANE-MONOOXYGENASE-RXN","compounds":"H(+) + methane + NADPH + O2 => H2O + methanol + NADP(+)"}
{"X":16901,"RHEA_ID":13643,"compounds":"H2O + methanol + NADP(+) => H(+) + methane + NADPH + O2"}
{"X":16902,"RHEA_ID":13645,"compounds":"beta-D-glucose + NADP(+) = D-glucono-1,5-lactone + H(+) + NADPH"}
{"X":16903,"RHEA_ID":13646,"DIRECTION":"LR","MASTER_ID":13645,"metacyc":"GLUCOSE-1-DEHYDROGENASE-NADP%2b-RXN","compounds":"beta-D-glucose + NADP(+) => D-glucono-1,5-lactone + H(+) + NADPH"}
{"X":16904,"RHEA_ID":13647,"compounds":"D-glucono-1,5-lactone + H(+) + NADPH => beta-D-glucose + NADP(+)"}
{"X":16905,"RHEA_ID":23466,"compounds":"3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine"}
{"X":16906,"RHEA_ID":13649,"compounds":"beta-D-glucose + NAD(+) = D-glucono-1,5-lactone + H(+) + NADH"}
{"X":16907,"RHEA_ID":13650,"compounds":"beta-D-glucose + NAD(+) => D-glucono-1,5-lactone + H(+) + NADH"}
{"X":16908,"RHEA_ID":13651,"compounds":"D-glucono-1,5-lactone + H(+) + NADH => beta-D-glucose + NAD(+)"}
{"X":16909,"RHEA_ID":23470,"compounds":"2,3-dihydroxybenzenesulfonate + NAD(+) + NH4(+) => 2-aminobenzenesulfonate + 2 H(+) + NADH + O2"}
{"X":16910,"RHEA_ID":13653,"DIRECTION":"UN","MASTER_ID":13653,"ec":"2.4.1.10","compounds":"[6)-beta-D-fructofuranosyl-(2->](n) alpha-D-glucopyranoside + sucrose = [6)-beta-D-fructofuranosyl-(2->](n+1) alpha-D-glucopyranoside + D-glucose"}
{"X":16911,"RHEA_ID":13654,"compounds":"[6)-beta-D-fructofuranosyl-(2->](n) alpha-D-glucopyranoside + sucrose => [6)-beta-D-fructofuranosyl-(2->](n+1) alpha-D-glucopyranoside + D-glucose"}
{"X":16912,"RHEA_ID":13655,"compounds":"[6)-beta-D-fructofuranosyl-(2->](n+1) alpha-D-glucopyranoside + D-glucose => [6)-beta-D-fructofuranosyl-(2->](n) alpha-D-glucopyranoside + sucrose"}
{"X":16913,"RHEA_ID":23474,"compounds":"alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose => 2 alpha,alpha'-trehalose 6-mycolate"}
{"X":16914,"RHEA_ID":13657,"DIRECTION":"UN","MASTER_ID":13657,"ec":"3.1.2.16","compounds":"acetyl-[citrate lyase ACP] + H2O = acetate + H(+) + holo-[citrate lyase ACP]"}
{"X":16915,"RHEA_ID":13658,"DIRECTION":"LR","MASTER_ID":13657,"ecocyc":"CITRATE-PRO-3S-LYASE-THIOLESTERASE-RXN","metacyc":"CITRATE-PRO-3S-LYASE-THIOLESTERASE-RXN","compounds":"acetyl-[citrate lyase ACP] + H2O => acetate + H(+) + holo-[citrate lyase ACP]"}
{"X":16916,"RHEA_ID":13659,"compounds":"acetate + H(+) + holo-[citrate lyase ACP] => acetyl-[citrate lyase ACP] + H2O"}
{"X":16917,"RHEA_ID":13661,"DIRECTION":"UN","MASTER_ID":13661,"ec":"3.5.3.5","metacyc":"FORMIMINOASPARTATE-DEIMINASE-RXN","compounds":"H2O + N-formimidoyl-L-aspartate = N-formyl-L-aspartate + NH4(+)"}
{"X":16918,"RHEA_ID":13662,"compounds":"H2O + N-formimidoyl-L-aspartate => N-formyl-L-aspartate + NH4(+)"}
{"X":16919,"RHEA_ID":13663,"compounds":"N-formyl-L-aspartate + NH4(+) => H2O + N-formimidoyl-L-aspartate"}
{"X":16920,"RHEA_ID":23482,"compounds":"dimethylmaleate => 2-methylene-3-methylsuccinate"}
{"X":16921,"RHEA_ID":13665,"DIRECTION":"UN","MASTER_ID":13665,"ec":"4.6.1.2","compounds":"GTP = 3',5'-cyclic GMP + diphosphate"}
{"X":16922,"RHEA_ID":13666,"DIRECTION":"LR","MASTER_ID":13665,"reactome":"R-HSA-392152.3","compounds":"GTP => 3',5'-cyclic GMP + diphosphate"}
{"X":16923,"RHEA_ID":13666,"DIRECTION":"LR","MASTER_ID":13665,"reactome":"R-HSA-74885.2","compounds":"GTP => 3',5'-cyclic GMP + diphosphate"}
{"X":16924,"RHEA_ID":13667,"compounds":"3',5'-cyclic GMP + diphosphate => GTP"}
{"X":16925,"RHEA_ID":34117,"DIRECTION":"RL","MASTER_ID":34115,"metacyc":"RXN-11565","compounds":"H(+) + L-aspartate 4-semialdehyde + NADPH + propane-1,3-diamine => carboxynorspermidine + H2O + NADP(+)"}
{"X":16926,"RHEA_ID":13669,"DIRECTION":"UN","MASTER_ID":13669,"ec":"4.1.1.51","compounds":"5-hydroxy-6-methylpyridine-3,4-dicarboxylate + H(+) = 3-hydroxy-2-methylpyridine-5-carboxylate + CO2"}
{"X":16927,"RHEA_ID":13670,"DIRECTION":"LR","MASTER_ID":13669,"metacyc":"4.1.1.51-RXN","compounds":"5-hydroxy-6-methylpyridine-3,4-dicarboxylate + H(+) => 3-hydroxy-2-methylpyridine-5-carboxylate + CO2"}
{"X":16928,"RHEA_ID":13671,"compounds":"3-hydroxy-2-methylpyridine-5-carboxylate + CO2 => 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + H(+)"}
{"X":16929,"RHEA_ID":34121,"compounds":"3,5,7-trioxododecanoyl-CoA + 3 CO2 + 3 CoA => 3 H(+) + hexanoyl-CoA + 3 malonyl-CoA"}
{"X":16930,"RHEA_ID":13673,"DIRECTION":"UN","MASTER_ID":13673,"ec":"2.7.7.59","compounds":"[protein-PII]-L-tyrosine + UTP = [protein-PII]-uridylyl-L-tyrosine + diphosphate"}
{"X":16931,"RHEA_ID":13674,"DIRECTION":"LR","MASTER_ID":13673,"ecocyc":"URITRANS-RXN","metacyc":"URITRANS-RXN","compounds":"[protein-PII]-L-tyrosine + UTP => [protein-PII]-uridylyl-L-tyrosine + diphosphate"}
{"X":16932,"RHEA_ID":13675,"compounds":"[protein-PII]-uridylyl-L-tyrosine + diphosphate => [protein-PII]-L-tyrosine + UTP"}
{"X":16933,"RHEA_ID":13677,"DIRECTION":"UN","MASTER_ID":13677,"ec":"5.1.3.1","compounds":"D-ribulose 5-phosphate = D-xylulose 5-phosphate"}
{"X":16934,"RHEA_ID":13678,"DIRECTION":"LR","MASTER_ID":13677,"macie":"M0270","reactome":"R-HSA-71303.4","compounds":"D-ribulose 5-phosphate => D-xylulose 5-phosphate"}
{"X":16935,"RHEA_ID":13679,"DIRECTION":"RL","MASTER_ID":13677,"reactome":"R-HSA-199803.3","compounds":"D-xylulose 5-phosphate => D-ribulose 5-phosphate"}
{"X":16936,"RHEA_ID":34129,"compounds":"cannabigerolate + diphosphate => (2E)-geranyl diphosphate + olivetolate"}
{"X":16937,"RHEA_ID":13681,"DIRECTION":"UN","MASTER_ID":13681,"ec":"2.1.1.37","compounds":"a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":16938,"RHEA_ID":13682,"DIRECTION":"LR","MASTER_ID":13681,"ecocyc":"DNA-CYTOSINE-5--METHYLTRANSFERASE-RXN","metacyc":"DNA-CYTOSINE-5--METHYLTRANSFERASE-RXN","compounds":"a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine => a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":16939,"RHEA_ID":13683,"compounds":"a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine => a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine"}
{"X":16940,"RHEA_ID":23503,"compounds":"H2O + N(6)-propanoyl-L-lysyl-[protein] + NAD(+) <=> 3''-O-propanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide"}
{"X":16941,"RHEA_ID":13685,"DIRECTION":"UN","MASTER_ID":13685,"ec":"1.3.1.72","compounds":"5alpha-cholest-7-en-3beta-ol + NADP(+) = 5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH"}
{"X":16942,"RHEA_ID":13686,"compounds":"5alpha-cholest-7-en-3beta-ol + NADP(+) => 5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH"}
{"X":16943,"RHEA_ID":13687,"DIRECTION":"RL","MASTER_ID":13685,"metacyc":"1.3.1.72-RXN","compounds":"5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH => 5alpha-cholest-7-en-3beta-ol + NADP(+)"}
{"X":16944,"RHEA_ID":13689,"DIRECTION":"UN","MASTER_ID":13689,"ec":"2.7.1.79","metacyc":"2.7.1.79-RXN","compounds":"diphosphate + glycerol = glycerol 1-phosphate + H(+) + phosphate"}
{"X":16945,"RHEA_ID":13690,"compounds":"diphosphate + glycerol => glycerol 1-phosphate + H(+) + phosphate"}
{"X":16946,"RHEA_ID":13691,"compounds":"glycerol 1-phosphate + H(+) + phosphate => diphosphate + glycerol"}
{"X":16947,"RHEA_ID":13693,"DIRECTION":"UN","MASTER_ID":13693,"ec":"2.1.1.19","compounds":"(6S)-5,6,7,8-tetrahydrofolate + trimethylsulfonium = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + dimethyl sulfide + H(+)"}
{"X":16948,"RHEA_ID":13694,"compounds":"(6S)-5,6,7,8-tetrahydrofolate + trimethylsulfonium => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + dimethyl sulfide + H(+)"}
{"X":16949,"RHEA_ID":13695,"DIRECTION":"RL","MASTER_ID":13693,"metacyc":"2.1.1.19-RXN","compounds":"(6S)-5-methyl-5,6,7,8-tetrahydrofolate + dimethyl sulfide + H(+) => (6S)-5,6,7,8-tetrahydrofolate + trimethylsulfonium"}
{"X":16950,"RHEA_ID":34145,"compounds":"Delta(9)-tetrahydrocannabinolate + H2O2 => cannabinerolate + O2"}
{"X":16951,"RHEA_ID":13697,"DIRECTION":"UN","MASTER_ID":13697,"ec":"2.7.1.15","compounds":"ATP + D-ribose = ADP + D-ribose 5-phosphate + H(+)"}
{"X":16952,"RHEA_ID":13698,"DIRECTION":"LR","MASTER_ID":13697,"ecocyc":"RIBOKIN-RXN","metacyc":"RIBOKIN-RXN","compounds":"ATP + D-ribose => ADP + D-ribose 5-phosphate + H(+)"}
{"X":16953,"RHEA_ID":13699,"compounds":"ADP + D-ribose 5-phosphate + H(+) => ATP + D-ribose"}
{"X":16954,"RHEA_ID":34149,"compounds":"2-deoxy-scyllo-inosamine + 2-oxoglutaramate => 2-deoxy-L-scyllo-inosose + L-glutamine"}
{"X":16955,"RHEA_ID":13701,"DIRECTION":"UN","MASTER_ID":13701,"ec":"2.3.1.31","compounds":"acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine"}
{"X":16956,"RHEA_ID":13702,"compounds":"acetyl-CoA + L-homoserine => CoA + O-acetyl-L-homoserine"}
{"X":16957,"RHEA_ID":13703,"compounds":"CoA + O-acetyl-L-homoserine => acetyl-CoA + L-homoserine"}
{"X":16958,"RHEA_ID":34153,"compounds":"2-deoxystreptamine + 2-oxoglutaramate => 3-amino-2,3-dideoxy-scyllo-inosose + L-glutamine"}
{"X":16959,"RHEA_ID":13705,"DIRECTION":"UN","MASTER_ID":13705,"ec":"2.4.1.138","metacyc":"2.4.1.138-RXN","compounds":"alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + UDP-N-acetyl-alpha-D-glucosamine = alpha-D-Man-(1->3)-[alpha-D-GlcNAc-(1->2)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + H(+) + UDP"}
{"X":16960,"RHEA_ID":13706,"compounds":"alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + UDP-N-acetyl-alpha-D-glucosamine => alpha-D-Man-(1->3)-[alpha-D-GlcNAc-(1->2)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + H(+) + UDP"}
{"X":16961,"RHEA_ID":13707,"compounds":"alpha-D-Man-(1->3)-[alpha-D-GlcNAc-(1->2)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + H(+) + UDP => alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":16962,"RHEA_ID":34157,"compounds":"CoA + H(+) + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose => acetyl-CoA + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine"}
{"X":16963,"RHEA_ID":13713,"DIRECTION":"UN","MASTER_ID":13713,"ec":"1.3.5.1","compounds":"a ubiquinone + succinate = a ubiquinol + fumarate"}
{"X":16964,"RHEA_ID":13714,"DIRECTION":"LR","MASTER_ID":13713,"ecocyc":"SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN","metacyc":"SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN","compounds":"a ubiquinone + succinate => a ubiquinol + fumarate"}
{"X":16965,"RHEA_ID":13715,"compounds":"a ubiquinol + fumarate => a ubiquinone + succinate"}
{"X":16966,"RHEA_ID":13717,"DIRECTION":"UN","MASTER_ID":13717,"ec":"1.1.1.267","compounds":"2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH"}
{"X":16967,"RHEA_ID":13718,"compounds":"2-C-methyl-D-erythritol 4-phosphate + NADP(+) => 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH"}
{"X":16968,"RHEA_ID":13719,"compounds":"1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH => 2-C-methyl-D-erythritol 4-phosphate + NADP(+)"}
{"X":16969,"RHEA_ID":34165,"compounds":"(2E,4Z)-4-hydroxy-6-oxohexa-2,4-dienoate + H(+) => hydroquinone + O2"}
{"X":16970,"RHEA_ID":13721,"DIRECTION":"UN","MASTER_ID":13721,"ec":"3.1.1.37","compounds":"H2O + testololactone = H(+) + testolate"}
{"X":16971,"RHEA_ID":13722,"DIRECTION":"LR","MASTER_ID":13721,"metacyc":"STEROID-LACTONASE-RXN","compounds":"H2O + testololactone => H(+) + testolate"}
{"X":16972,"RHEA_ID":13723,"compounds":"H(+) + testolate => H2O + testololactone"}
{"X":16973,"RHEA_ID":23538,"compounds":"alpha-D-glucose 6-phosphate => alpha-D-glucose 1-phosphate"}
{"X":16974,"RHEA_ID":13725,"DIRECTION":"UN","MASTER_ID":13725,"ec":"2.3.1.157","compounds":"acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate"}
{"X":16975,"RHEA_ID":13726,"DIRECTION":"LR","MASTER_ID":13725,"ecocyc":"2.3.1.157-RXN","metacyc":"2.3.1.157-RXN","compounds":"acetyl-CoA + alpha-D-glucosamine 1-phosphate => CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate"}
{"X":16976,"RHEA_ID":13727,"compounds":"CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate => acetyl-CoA + alpha-D-glucosamine 1-phosphate"}
{"X":16977,"RHEA_ID":23542,"compounds":"AMP + diphosphate + L-glutamyl-tRNA(Glu) => ATP + L-glutamate + tRNA(Glu)"}
{"X":16978,"RHEA_ID":13729,"DIRECTION":"UN","MASTER_ID":13729,"ec":"4.6.1.15","compounds":"FAD = AMP + H(+) + riboflavin cyclic-4',5'-phosphate"}
{"X":16979,"RHEA_ID":13730,"compounds":"FAD => AMP + H(+) + riboflavin cyclic-4',5'-phosphate"}
{"X":16980,"RHEA_ID":13731,"compounds":"AMP + H(+) + riboflavin cyclic-4',5'-phosphate => FAD"}
{"X":16981,"RHEA_ID":23546,"compounds":"a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP => a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-alpha-D-glucose"}
{"X":16982,"RHEA_ID":13733,"DIRECTION":"UN","MASTER_ID":13733,"ec":"1.3.1.74","compounds":"an n-alkanal + NAD(+) = an alk-2-enal + H(+) + NADH"}
{"X":16983,"RHEA_ID":13734,"compounds":"an n-alkanal + NAD(+) => an alk-2-enal + H(+) + NADH"}
{"X":16984,"RHEA_ID":13735,"DIRECTION":"RL","MASTER_ID":13733,"metacyc":"RXN-11696","compounds":"an alk-2-enal + H(+) + NADH => an n-alkanal + NAD(+)"}
{"X":16985,"RHEA_ID":13737,"DIRECTION":"UN","MASTER_ID":13737,"ec":"1.3.1.74","compounds":"an n-alkanal + NADP(+) = an alk-2-enal + H(+) + NADPH"}
{"X":16986,"RHEA_ID":13737,"DIRECTION":"UN","MASTER_ID":13737,"ec":"1.3.1.102","compounds":"an n-alkanal + NADP(+) = an alk-2-enal + H(+) + NADPH"}
{"X":16987,"RHEA_ID":13738,"compounds":"an n-alkanal + NADP(+) => an alk-2-enal + H(+) + NADPH"}
{"X":16988,"RHEA_ID":13739,"DIRECTION":"RL","MASTER_ID":13737,"metacyc":"RXN-11696","compounds":"an alk-2-enal + H(+) + NADPH => an n-alkanal + NADP(+)"}
{"X":16989,"RHEA_ID":13741,"DIRECTION":"UN","MASTER_ID":13741,"ec":"2.6.1.28","compounds":"3-phenylpyruvate + L-tryptophan = indole-3-pyruvate + L-phenylalanine"}
{"X":16990,"RHEA_ID":13742,"compounds":"3-phenylpyruvate + L-tryptophan => indole-3-pyruvate + L-phenylalanine"}
{"X":16991,"RHEA_ID":13743,"compounds":"indole-3-pyruvate + L-phenylalanine => 3-phenylpyruvate + L-tryptophan"}
{"X":16992,"RHEA_ID":44129,"compounds":"(9E)-octadecenoyl-CoA + hexadecan-1-ol => CoA + hexadecanyl (9E)-octadecenoate"}
{"X":16993,"RHEA_ID":13745,"compounds":"ascopyrone M = microthecin"}
{"X":16994,"RHEA_ID":13746,"DIRECTION":"LR","MASTER_ID":13745,"metacyc":"RXN-8986","compounds":"ascopyrone M => microthecin"}
{"X":16995,"RHEA_ID":13747,"compounds":"microthecin => ascopyrone M"}
{"X":16996,"RHEA_ID":23563,"compounds":"adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate <=> adenosylcob(III)alamin 5'-phosphate + GMP + H(+)"}
{"X":16997,"RHEA_ID":13749,"DIRECTION":"UN","MASTER_ID":13749,"ec":"2.7.4.10","compounds":"a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP"}
{"X":16998,"RHEA_ID":13750,"compounds":"a ribonucleoside 5'-triphosphate + AMP => a ribonucleoside 5'-diphosphate + ADP"}
{"X":16999,"RHEA_ID":13751,"compounds":"a ribonucleoside 5'-diphosphate + ADP => a ribonucleoside 5'-triphosphate + AMP"}
{"X":17000,"RHEA_ID":44137,"compounds":"dodecanoyl-CoA + hexadecan-1-ol => CoA + hexadecanyl dodecanoate"}
{"X":17001,"RHEA_ID":13753,"DIRECTION":"UN","MASTER_ID":13753,"ec":"1.4.1.14","compounds":"2 L-glutamate + NAD(+) = 2-oxoglutarate + H(+) + L-glutamine + NADH"}
{"X":17002,"RHEA_ID":13754,"compounds":"2 L-glutamate + NAD(+) => 2-oxoglutarate + H(+) + L-glutamine + NADH"}
{"X":17003,"RHEA_ID":13755,"DIRECTION":"RL","MASTER_ID":13753,"metacyc":"GLUTAMATE-SYNTHASE-NADH-RXN","compounds":"2-oxoglutarate + H(+) + L-glutamine + NADH => 2 L-glutamate + NAD(+)"}
{"X":17004,"RHEA_ID":13757,"DIRECTION":"UN","MASTER_ID":13757,"ec":"2.4.1.195","compounds":"(Z)-2-phenyl-1-thioacetohydroximate + UDP-alpha-D-glucose = (Z)-desulfoglucotropeolin + UDP"}
{"X":17005,"RHEA_ID":13758,"DIRECTION":"LR","MASTER_ID":13757,"metacyc":"2.4.1.195-RXN","compounds":"(Z)-2-phenyl-1-thioacetohydroximate + UDP-alpha-D-glucose => (Z)-desulfoglucotropeolin + UDP"}
{"X":17006,"RHEA_ID":13759,"compounds":"(Z)-desulfoglucotropeolin + UDP => (Z)-2-phenyl-1-thioacetohydroximate + UDP-alpha-D-glucose"}
{"X":17007,"RHEA_ID":44145,"compounds":"acetyl-CoA + L-methionine => CoA + H(+) + N(alpha)-acetyl-L-methionine"}
{"X":17008,"RHEA_ID":13761,"DIRECTION":"UN","MASTER_ID":13761,"ec":"2.1.1.12","compounds":"L-methionine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + S-methyl-L-methionine"}
{"X":17009,"RHEA_ID":13762,"DIRECTION":"LR","MASTER_ID":13761,"metacyc":"METHIONINE-S-METHYLTRANSFERASE-RXN","compounds":"L-methionine + S-adenosyl-L-methionine => S-adenosyl-L-homocysteine + S-methyl-L-methionine"}
{"X":17010,"RHEA_ID":13763,"compounds":"S-adenosyl-L-homocysteine + S-methyl-L-methionine => L-methionine + S-adenosyl-L-methionine"}
{"X":17011,"RHEA_ID":44149,"compounds":"L-lysine => D-beta-lysine"}
{"X":17012,"RHEA_ID":13765,"DIRECTION":"UN","MASTER_ID":13765,"ec":"3.8.1.1","metacyc":"ALKYLHALIDASE-RXN","compounds":"bromochloromethane + H2O = bromide + chloride + formaldehyde + 2 H(+)"}
{"X":17013,"RHEA_ID":13766,"compounds":"bromochloromethane + H2O => bromide + chloride + formaldehyde + 2 H(+)"}
{"X":17014,"RHEA_ID":13767,"compounds":"bromide + chloride + formaldehyde + 2 H(+) => bromochloromethane + H2O"}
{"X":17015,"RHEA_ID":13769,"DIRECTION":"UN","MASTER_ID":13769,"ec":"1.1.1.6","compounds":"glycerol + NAD(+) = dihydroxyacetone + H(+) + NADH"}
{"X":17016,"RHEA_ID":13770,"DIRECTION":"LR","MASTER_ID":13769,"macie":"M0312","compounds":"glycerol + NAD(+) => dihydroxyacetone + H(+) + NADH"}
{"X":17017,"RHEA_ID":13771,"compounds":"dihydroxyacetone + H(+) + NADH => glycerol + NAD(+)"}
{"X":17018,"RHEA_ID":13773,"DIRECTION":"UN","MASTER_ID":13773,"ec":"1.14.19.64","compounds":"(S)-cheilanthifoline + O2 + reduced [NADPH--hemoprotein reductase] = (S)-stylopine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":17019,"RHEA_ID":13774,"DIRECTION":"LR","MASTER_ID":13773,"metacyc":"1.1.3.32-RXN","compounds":"(S)-cheilanthifoline + O2 + reduced [NADPH--hemoprotein reductase] => (S)-stylopine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":17020,"RHEA_ID":13775,"compounds":"(S)-stylopine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-cheilanthifoline + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":17021,"RHEA_ID":44161,"DIRECTION":"LR","MASTER_ID":44160,"metacyc":"RXN-10954","compounds":"1D-myo-inositol 6-phosphate + H2O => myo-inositol + phosphate"}
{"X":17022,"RHEA_ID":13777,"DIRECTION":"UN","MASTER_ID":13777,"ec":"6.3.4.7","compounds":"ATP + D-ribose 5-phosphate + NH4(+) = 5-phospho-D-ribosylamine + ADP + H(+) + phosphate"}
{"X":17023,"RHEA_ID":13778,"DIRECTION":"LR","MASTER_ID":13777,"metacyc":"RIBOSE-5-PHOSPHATE--AMMONIA-LIGASE-RXN","compounds":"ATP + D-ribose 5-phosphate + NH4(+) => 5-phospho-D-ribosylamine + ADP + H(+) + phosphate"}
{"X":17024,"RHEA_ID":13779,"compounds":"5-phospho-D-ribosylamine + ADP + H(+) + phosphate => ATP + D-ribose 5-phosphate + NH4(+)"}
{"X":17025,"RHEA_ID":23594,"compounds":"D-glyceraldehyde + H(+) + NADPH => glycerol + NADP(+)"}
{"X":17026,"RHEA_ID":13781,"DIRECTION":"UN","MASTER_ID":13781,"ec":"1.4.3.2","compounds":"an L-alpha-amino acid + H2O + O2 = a 2-oxocarboxylate + H2O2 + NH4(+)"}
{"X":17027,"RHEA_ID":13782,"DIRECTION":"LR","MASTER_ID":13781,"metacyc":"L-AMINO-ACID-OXIDASE-RXN","compounds":"an L-alpha-amino acid + H2O + O2 => a 2-oxocarboxylate + H2O2 + NH4(+)"}
{"X":17028,"RHEA_ID":13783,"compounds":"a 2-oxocarboxylate + H2O2 + NH4(+) => an L-alpha-amino acid + H2O + O2"}
{"X":17029,"RHEA_ID":13785,"DIRECTION":"UN","MASTER_ID":13785,"ec":"4.2.1.56","compounds":"citramalyl-CoA = H2O + itaconyl-CoA"}
{"X":17030,"RHEA_ID":13786,"compounds":"citramalyl-CoA => H2O + itaconyl-CoA"}
{"X":17031,"RHEA_ID":13787,"DIRECTION":"RL","MASTER_ID":13785,"metacyc":"ITACONYL-COA-HYDRATASE-RXN","compounds":"H2O + itaconyl-CoA => citramalyl-CoA"}
{"X":17032,"RHEA_ID":23602,"compounds":"2-oxohexanoate + L-glutamate => 2-oxoglutarate + L-2-aminohexanoate"}
{"X":17033,"RHEA_ID":13789,"DIRECTION":"UN","MASTER_ID":13789,"ec":"2.4.1.371","compounds":"[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenol + 2 GDP-alpha-D-mannose = alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-di-trans,octa-cis-undecaprenol + 2 GDP + 2 H(+)"}
{"X":17034,"RHEA_ID":13790,"DIRECTION":"LR","MASTER_ID":13789,"metacyc":"RXN-18776","compounds":"[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenol + 2 GDP-alpha-D-mannose => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-di-trans,octa-cis-undecaprenol + 2 GDP + 2 H(+)"}
{"X":17035,"RHEA_ID":13791,"compounds":"alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-di-trans,octa-cis-undecaprenol + 2 GDP + 2 H(+) => [alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenol + 2 GDP-alpha-D-mannose"}
{"X":17036,"RHEA_ID":13792,"compounds":"[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenol + 2 GDP-alpha-D-mannose <=> alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-di-trans,octa-cis-undecaprenol + 2 GDP + 2 H(+)"}
{"X":17037,"RHEA_ID":13793,"DIRECTION":"UN","MASTER_ID":13793,"ec":"5.4.99.4","compounds":"2-methyleneglutarate = 2-methylene-3-methylsuccinate"}
{"X":17038,"RHEA_ID":13794,"DIRECTION":"LR","MASTER_ID":13793,"metacyc":"2-METHYLENEGLUTARATE-MUTASE-RXN","compounds":"2-methyleneglutarate => 2-methylene-3-methylsuccinate"}
{"X":17039,"RHEA_ID":13795,"compounds":"2-methylene-3-methylsuccinate => 2-methyleneglutarate"}
{"X":17040,"RHEA_ID":23610,"compounds":"cyanurate + isopropylamine => H(+) + H2O + N-isopropylammelide"}
{"X":17041,"RHEA_ID":13797,"DIRECTION":"UN","MASTER_ID":13797,"ec":"3.1.3.51","compounds":"dolichyl phosphate + H2O = di-trans,poly-cis-dolichol + phosphate"}
{"X":17042,"RHEA_ID":13798,"DIRECTION":"LR","MASTER_ID":13797,"metacyc":"DOLICHYL-PHOSPHATASE-RXN","compounds":"dolichyl phosphate + H2O => di-trans,poly-cis-dolichol + phosphate"}
{"X":17043,"RHEA_ID":13799,"compounds":"di-trans,poly-cis-dolichol + phosphate => dolichyl phosphate + H2O"}
{"X":17044,"RHEA_ID":13801,"DIRECTION":"UN","MASTER_ID":13801,"ec":"1.8.1.2","compounds":"3 H2O + hydrogen sulfide + 3 NADP(+) = 4 H(+) + 3 NADPH + sulfite"}
{"X":17045,"RHEA_ID":13802,"compounds":"3 H2O + hydrogen sulfide + 3 NADP(+) => 4 H(+) + 3 NADPH + sulfite"}
{"X":17046,"RHEA_ID":13803,"DIRECTION":"RL","MASTER_ID":13801,"ecocyc":"SULFITE-REDUCT-RXN","metacyc":"SULFITE-REDUCT-RXN","compounds":"4 H(+) + 3 NADPH + sulfite => 3 H2O + hydrogen sulfide + 3 NADP(+)"}
{"X":17047,"RHEA_ID":13805,"DIRECTION":"UN","MASTER_ID":13805,"ec":"1.3.99.5","compounds":"A + a 3-oxo-5alpha-steroid = a 3-oxo-Delta(4)-steroid + AH2"}
{"X":17048,"RHEA_ID":13806,"compounds":"A + a 3-oxo-5alpha-steroid => a 3-oxo-Delta(4)-steroid + AH2"}
{"X":17049,"RHEA_ID":13807,"compounds":"a 3-oxo-Delta(4)-steroid + AH2 => A + a 3-oxo-5alpha-steroid"}
{"X":17050,"RHEA_ID":23622,"compounds":"AMP + deoxyamidinoproclavaminate + diphosphate + H(+) => ATP + N(2)-(2-carboxyethyl)-L-arginine"}
{"X":17051,"RHEA_ID":13809,"DIRECTION":"UN","MASTER_ID":13809,"ec":"2.5.1.35","metacyc":"ASPULVINONE-DIMETHYLALLYLTRANSFERASE-RXN","compounds":"aspulvinone E + 2 dimethylallyl diphosphate = aspulvinone H + 2 diphosphate"}
{"X":17052,"RHEA_ID":13810,"compounds":"aspulvinone E + 2 dimethylallyl diphosphate => aspulvinone H + 2 diphosphate"}
{"X":17053,"RHEA_ID":13811,"compounds":"aspulvinone H + 2 diphosphate => aspulvinone E + 2 dimethylallyl diphosphate"}
{"X":17054,"RHEA_ID":23626,"DIRECTION":"RL","MASTER_ID":23624,"ecocyc":"RXN0-1281","metacyc":"RXN0-1281","compounds":"a uridine in tRNA + H(+) + NADPH => a 5,6-dihydrouridine in tRNA + NADP(+)"}
{"X":17055,"RHEA_ID":13813,"DIRECTION":"UN","MASTER_ID":13813,"ec":"1.14.12.3","compounds":"benzene + H(+) + NADH + O2 = cis-1,2-dihydrobenzene-1,2-diol + NAD(+)"}
{"X":17056,"RHEA_ID":13814,"DIRECTION":"LR","MASTER_ID":13813,"metacyc":"BENZENE-12-DIOXYGENASE-RXN","compounds":"benzene + H(+) + NADH + O2 => cis-1,2-dihydrobenzene-1,2-diol + NAD(+)"}
{"X":17057,"RHEA_ID":13815,"compounds":"cis-1,2-dihydrobenzene-1,2-diol + NAD(+) => benzene + H(+) + NADH + O2"}
{"X":17058,"RHEA_ID":23630,"compounds":"a beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+) => a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose"}
{"X":17059,"RHEA_ID":13817,"DIRECTION":"UN","MASTER_ID":13817,"ec":"1.17.4.4","compounds":"[protein]-disulfide + H2O + phylloquinone = 2,3-epoxyphylloquinone + [protein]-dithiol"}
{"X":17060,"RHEA_ID":13818,"compounds":"[protein]-disulfide + H2O + phylloquinone => 2,3-epoxyphylloquinone + [protein]-dithiol"}
{"X":17061,"RHEA_ID":13819,"DIRECTION":"RL","MASTER_ID":13817,"metacyc":"1.1.4.1-RXN","compounds":"2,3-epoxyphylloquinone + [protein]-dithiol => [protein]-disulfide + H2O + phylloquinone"}
{"X":17062,"RHEA_ID":23633,"DIRECTION":"LR","MASTER_ID":23632,"metacyc":"RXN-7969","reactome":"R-HSA-70967.4","compounds":"D-threo-isocitrate + NAD(+) => 2-oxoglutarate + CO2 + NADH"}
{"X":17063,"RHEA_ID":13821,"DIRECTION":"UN","MASTER_ID":13821,"ec":"1.14.11.64","compounds":"2-oxoglutarate + glutarate + O2 = (S)-2-hydroxyglutarate + CO2 + succinate"}
{"X":17064,"RHEA_ID":13822,"DIRECTION":"LR","MASTER_ID":13821,"ecocyc":"RXN0-7316","metacyc":"RXN0-7316","compounds":"2-oxoglutarate + glutarate + O2 => (S)-2-hydroxyglutarate + CO2 + succinate"}
{"X":17065,"RHEA_ID":13823,"compounds":"(S)-2-hydroxyglutarate + CO2 + succinate => 2-oxoglutarate + glutarate + O2"}
{"X":17066,"RHEA_ID":23640,"DIRECTION":"UN","MASTER_ID":23640,"ec":"1.14.17.4","compounds":"1-aminocyclopropane-1-carboxylate + L-ascorbate + O2 = CO2 + ethene + 2 H2O + hydrogen cyanide + L-dehydroascorbate"}
{"X":17067,"RHEA_ID":13825,"DIRECTION":"UN","MASTER_ID":13825,"ec":"1.1.1.281","compounds":"GDP-alpha-D-rhamnose + NAD(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH"}
{"X":17068,"RHEA_ID":13825,"DIRECTION":"UN","MASTER_ID":13825,"ec":"1.1.1.187","compounds":"GDP-alpha-D-rhamnose + NAD(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH"}
{"X":17069,"RHEA_ID":13826,"compounds":"GDP-alpha-D-rhamnose + NAD(+) => GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH"}
{"X":17070,"RHEA_ID":13827,"DIRECTION":"RL","MASTER_ID":13825,"metacyc":"GDP-4-DEHYDRO-D-RHAMNOSE-REDUCTASE-RXN","compounds":"GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH => GDP-alpha-D-rhamnose + NAD(+)"}
{"X":17071,"RHEA_ID":23645,"DIRECTION":"LR","MASTER_ID":23644,"metacyc":"RXN-7977","compounds":"lithocholate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + hyodeoxycholate + oxidized [NADPH--hemoprotein reductase]"}
{"X":17072,"RHEA_ID":13829,"DIRECTION":"UN","MASTER_ID":13829,"ec":"1.1.1.281","compounds":"GDP-alpha-D-rhamnose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH"}
{"X":17073,"RHEA_ID":13829,"DIRECTION":"UN","MASTER_ID":13829,"ec":"1.1.1.187","compounds":"GDP-alpha-D-rhamnose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH"}
{"X":17074,"RHEA_ID":13830,"compounds":"GDP-alpha-D-rhamnose + NADP(+) => GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH"}
{"X":17075,"RHEA_ID":13831,"DIRECTION":"RL","MASTER_ID":13829,"metacyc":"GDP-4-DEHYDRO-D-RHAMNOSE-REDUCTASE-RXN","compounds":"GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH => GDP-alpha-D-rhamnose + NADP(+)"}
{"X":17076,"RHEA_ID":23648,"DIRECTION":"UN","MASTER_ID":23648,"ec":"1.1.1.344","metacyc":"1.1.1.134-RXN","compounds":"dTDP-6-deoxy-beta-L-talose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH"}
{"X":17077,"RHEA_ID":13833,"DIRECTION":"UN","MASTER_ID":13833,"ec":"2.6.1.84","compounds":"L-arginine + pyruvate = 5-guanidino-2-oxopentanoate + L-alanine"}
{"X":17078,"RHEA_ID":13834,"compounds":"L-arginine + pyruvate => 5-guanidino-2-oxopentanoate + L-alanine"}
{"X":17079,"RHEA_ID":13835,"compounds":"5-guanidino-2-oxopentanoate + L-alanine => L-arginine + pyruvate"}
{"X":17080,"RHEA_ID":34284,"DIRECTION":"LR","MASTER_ID":34283,"metacyc":"RXN-5861","compounds":"2 L-tyrosine + O2 => 2 L-dopa"}
{"X":17081,"RHEA_ID":13837,"DIRECTION":"UN","MASTER_ID":13837,"ec":"1.3.1.64","metacyc":"1.3.1.64-RXN","compounds":"cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+) = 4,5-dihydroxyphthalate + H(+) + NADH"}
{"X":17082,"RHEA_ID":13838,"compounds":"cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+) => 4,5-dihydroxyphthalate + H(+) + NADH"}
{"X":17083,"RHEA_ID":13839,"compounds":"4,5-dihydroxyphthalate + H(+) + NADH => cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+)"}
{"X":17084,"RHEA_ID":13841,"DIRECTION":"UN","MASTER_ID":13841,"ec":"1.16.1.2","metacyc":"DIFFERIC-TRANSFERRIN-REDUCTASE-RXN","compounds":"[transferrin[Fe(II)2]] + H(+) + NAD(+) = [transferrin[Fe(III)2]] + NADH"}
{"X":17085,"RHEA_ID":13842,"compounds":"[transferrin[Fe(II)2]] + H(+) + NAD(+) => [transferrin[Fe(III)2]] + NADH"}
{"X":17086,"RHEA_ID":13843,"compounds":"[transferrin[Fe(III)2]] + NADH => [transferrin[Fe(II)2]] + H(+) + NAD(+)"}
{"X":17087,"RHEA_ID":13845,"DIRECTION":"UN","MASTER_ID":13845,"ec":"4.1.1.54","compounds":"dihydroxyfumarate + H(+) = 2-hydroxy-3-oxopropanoate + CO2"}
{"X":17088,"RHEA_ID":13846,"DIRECTION":"LR","MASTER_ID":13845,"metacyc":"DIHYDROXYFUMARATE-DECARBOXYLASE-RXN","compounds":"dihydroxyfumarate + H(+) => 2-hydroxy-3-oxopropanoate + CO2"}
{"X":17089,"RHEA_ID":13847,"compounds":"2-hydroxy-3-oxopropanoate + CO2 => dihydroxyfumarate + H(+)"}
{"X":17090,"RHEA_ID":34296,"DIRECTION":"LR","MASTER_ID":34295,"metacyc":"RXN-8455","compounds":"2',3,4,4',6'-pentahydroxychalcone + UDP-alpha-D-glucose => 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP"}
{"X":17091,"RHEA_ID":13849,"DIRECTION":"UN","MASTER_ID":13849,"ec":"5.3.1.3","compounds":"D-arabinose = D-ribulose"}
{"X":17092,"RHEA_ID":13850,"compounds":"D-arabinose => D-ribulose"}
{"X":17093,"RHEA_ID":13851,"compounds":"D-ribulose => D-arabinose"}
{"X":17094,"RHEA_ID":13853,"DIRECTION":"UN","MASTER_ID":13853,"ec":"6.3.1.7","compounds":"4-methylene-L-glutamate + ATP + NH4(+) = 4-methylene-L-glutamine + AMP + diphosphate + H(+)"}
{"X":17095,"RHEA_ID":13854,"DIRECTION":"LR","MASTER_ID":13853,"metacyc":"4-METHYLENEGLUTAMATE--AMMONIA-LIGASE-RXN","compounds":"4-methylene-L-glutamate + ATP + NH4(+) => 4-methylene-L-glutamine + AMP + diphosphate + H(+)"}
{"X":17096,"RHEA_ID":13855,"compounds":"4-methylene-L-glutamine + AMP + diphosphate + H(+) => 4-methylene-L-glutamate + ATP + NH4(+)"}
{"X":17097,"RHEA_ID":34304,"compounds":"L-lysine => L-pipecolate + NH4(+)"}
{"X":17098,"RHEA_ID":13857,"DIRECTION":"UN","MASTER_ID":13857,"ec":"3.1.4.48","compounds":"dolichyl beta-D-glucosyl phosphate + H2O = D-glucose + dolichyl phosphate + H(+)"}
{"X":17099,"RHEA_ID":13858,"DIRECTION":"LR","MASTER_ID":13857,"metacyc":"3.1.4.48-RXN","compounds":"dolichyl beta-D-glucosyl phosphate + H2O => D-glucose + dolichyl phosphate + H(+)"}
{"X":17100,"RHEA_ID":13859,"compounds":"D-glucose + dolichyl phosphate + H(+) => dolichyl beta-D-glucosyl phosphate + H2O"}
{"X":17101,"RHEA_ID":13861,"DIRECTION":"UN","MASTER_ID":13861,"ec":"1.1.1.175","compounds":"D-xylose + NAD(+) = D-xylono-1,5-lactone + H(+) + NADH"}
{"X":17102,"RHEA_ID":13861,"DIRECTION":"UN","MASTER_ID":13861,"ec":"1.1.1.359","compounds":"D-xylose + NAD(+) = D-xylono-1,5-lactone + H(+) + NADH"}
{"X":17103,"RHEA_ID":13862,"compounds":"D-xylose + NAD(+) => D-xylono-1,5-lactone + H(+) + NADH"}
{"X":17104,"RHEA_ID":13863,"compounds":"D-xylono-1,5-lactone + H(+) + NADH => D-xylose + NAD(+)"}
{"X":17105,"RHEA_ID":23680,"DIRECTION":"UN","MASTER_ID":23680,"ec":"3.6.1.15","compounds":"a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + H(+) + phosphate"}
{"X":17106,"RHEA_ID":13865,"DIRECTION":"UN","MASTER_ID":13865,"ec":"2.4.1.142","compounds":"GDP-alpha-D-mannose + N,N'-diacetylchitobiosyl diphosphodolichol = beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)"}
{"X":17107,"RHEA_ID":13866,"DIRECTION":"LR","MASTER_ID":13865,"metacyc":"2.4.1.142-RXN","compounds":"GDP-alpha-D-mannose + N,N'-diacetylchitobiosyl diphosphodolichol => beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)"}
{"X":17108,"RHEA_ID":13867,"compounds":"beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+) => GDP-alpha-D-mannose + N,N'-diacetylchitobiosyl diphosphodolichol"}
{"X":17109,"RHEA_ID":23684,"DIRECTION":"UN","MASTER_ID":23684,"ec":"1.14.14.97","compounds":"(S)-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] = allocryptopine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":17110,"RHEA_ID":13869,"DIRECTION":"UN","MASTER_ID":13869,"ec":"1.3.1.12","compounds":"NAD(+) + prephenate = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADH"}
{"X":17111,"RHEA_ID":13870,"DIRECTION":"LR","MASTER_ID":13869,"ecocyc":"PREPHENATEDEHYDROG-RXN","metacyc":"PREPHENATEDEHYDROG-RXN","compounds":"NAD(+) + prephenate => 3-(4-hydroxyphenyl)pyruvate + CO2 + NADH"}
{"X":17112,"RHEA_ID":13871,"compounds":"3-(4-hydroxyphenyl)pyruvate + CO2 + NADH => NAD(+) + prephenate"}
{"X":17113,"RHEA_ID":23688,"DIRECTION":"UN","MASTER_ID":23688,"ec":"3.5.4.2","compounds":"adenine + H(+) + H2O = hypoxanthine + NH4(+)"}
{"X":17114,"RHEA_ID":13873,"DIRECTION":"UN","MASTER_ID":13873,"ec":"4.2.3.18","compounds":"(+)-copalyl diphosphate = abieta-7,13-diene + diphosphate"}
{"X":17115,"RHEA_ID":13874,"DIRECTION":"LR","MASTER_ID":13873,"metacyc":"4.2.3.18-RXN","compounds":"(+)-copalyl diphosphate => abieta-7,13-diene + diphosphate"}
{"X":17116,"RHEA_ID":13875,"compounds":"abieta-7,13-diene + diphosphate => (+)-copalyl diphosphate"}
{"X":17117,"RHEA_ID":23692,"DIRECTION":"UN","MASTER_ID":23692,"ec":"4.2.1.31","compounds":"(R)-malate = H2O + maleate"}
{"X":17118,"RHEA_ID":13877,"DIRECTION":"UN","MASTER_ID":13877,"ec":"2.6.1.13","compounds":"a 2-oxocarboxylate + L-ornithine = an L-alpha-amino acid + L-glutamate 5-semialdehyde"}
{"X":17119,"RHEA_ID":13878,"compounds":"a 2-oxocarboxylate + L-ornithine => an L-alpha-amino acid + L-glutamate 5-semialdehyde"}
{"X":17120,"RHEA_ID":13879,"compounds":"an L-alpha-amino acid + L-glutamate 5-semialdehyde => a 2-oxocarboxylate + L-ornithine"}
{"X":17121,"RHEA_ID":23696,"DIRECTION":"UN","MASTER_ID":23696,"ec":"1.13.99.1","compounds":"myo-inositol + O2 = D-glucuronate + H(+) + H2O"}
{"X":17122,"RHEA_ID":13881,"DIRECTION":"UN","MASTER_ID":13881,"ec":"1.2.5.2","metacyc":"1.2.99.3-RXN","compounds":"a quinone + an aldehyde + H2O = a carboxylate + a quinol + H(+)"}
{"X":17123,"RHEA_ID":13882,"compounds":"a quinone + an aldehyde + H2O => a carboxylate + a quinol + H(+)"}
{"X":17124,"RHEA_ID":13883,"compounds":"a carboxylate + a quinol + H(+) => a quinone + an aldehyde + H2O"}
{"X":17125,"RHEA_ID":13885,"DIRECTION":"UN","MASTER_ID":13885,"ec":"4.1.1.60","compounds":"H2O + stipitatonate = CO2 + stipitatate"}
{"X":17126,"RHEA_ID":13886,"DIRECTION":"LR","MASTER_ID":13885,"metacyc":"STIPITATONATE-DECARBOXYLASE-RXN","compounds":"H2O + stipitatonate => CO2 + stipitatate"}
{"X":17127,"RHEA_ID":13887,"compounds":"CO2 + stipitatate => H2O + stipitatonate"}
{"X":17128,"RHEA_ID":23704,"DIRECTION":"UN","MASTER_ID":23704,"ec":"3.5.4.25","compounds":"GTP + 3 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + diphosphate + formate + 2 H(+)"}
{"X":17129,"RHEA_ID":13889,"DIRECTION":"UN","MASTER_ID":13889,"ec":"3.6.1.18","compounds":"FAD + H2O = AMP + FMN + 2 H(+)"}
{"X":17130,"RHEA_ID":13890,"DIRECTION":"LR","MASTER_ID":13889,"reactome":"R-HSA-196955.2","compounds":"FAD + H2O => AMP + FMN + 2 H(+)"}
{"X":17131,"RHEA_ID":13891,"compounds":"AMP + FMN + 2 H(+) => FAD + H2O"}
{"X":17132,"RHEA_ID":23708,"DIRECTION":"UN","MASTER_ID":23708,"ec":"2.4.1.129","compounds":"[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-diphospho-di-trans,octa-cis-undecaprenol + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-diphospho-di-trans-octa-cis-undecaprenol + di-trans,octa-cis-undecaprenyl diphosphate + H(+)"}
{"X":17133,"RHEA_ID":13893,"DIRECTION":"UN","MASTER_ID":13893,"ec":"3.6.1.29","compounds":"H2O + P(1),P(3)-bis(5'-adenosyl) triphosphate = ADP + AMP + 2 H(+)"}
{"X":17134,"RHEA_ID":13894,"DIRECTION":"LR","MASTER_ID":13893,"ecocyc":"BIS5-ADENOSYL-TRIPHOSPHATASE-RXN","macie":"M0101","metacyc":"BIS5-ADENOSYL-TRIPHOSPHATASE-RXN","compounds":"H2O + P(1),P(3)-bis(5'-adenosyl) triphosphate => ADP + AMP + 2 H(+)"}
{"X":17135,"RHEA_ID":13895,"compounds":"ADP + AMP + 2 H(+) => H2O + P(1),P(3)-bis(5'-adenosyl) triphosphate"}
{"X":17136,"RHEA_ID":23712,"DIRECTION":"UN","MASTER_ID":23712,"ec":"1.1.1.151","metacyc":"1.1.1.151-RXN","compounds":"NADP(+) + pregnan-21-ol = H(+) + NADPH + pregnan-21-al"}
{"X":17137,"RHEA_ID":13897,"DIRECTION":"UN","MASTER_ID":13897,"ec":"5.4.99.5","compounds":"chorismate = prephenate"}
{"X":17138,"RHEA_ID":13898,"DIRECTION":"LR","MASTER_ID":13897,"ecocyc":"CHORISMATEMUT-RXN","compounds":"chorismate => prephenate"}
{"X":17139,"RHEA_ID":13899,"compounds":"prephenate => chorismate"}
{"X":17140,"RHEA_ID":23716,"DIRECTION":"UN","MASTER_ID":23716,"ec":"5.3.3.8","compounds":"(3Z)-dodecenoyl-CoA = (2E)-dodecenoyl-CoA"}
{"X":17141,"RHEA_ID":13901,"compounds":"H2O + N-(aminomethyl)urea = N-(hydroxymethyl)urea + NH4(+)"}
{"X":17142,"RHEA_ID":13902,"DIRECTION":"LR","MASTER_ID":13901,"metacyc":"RXN-13201","compounds":"H2O + N-(aminomethyl)urea => N-(hydroxymethyl)urea + NH4(+)"}
{"X":17143,"RHEA_ID":13903,"compounds":"N-(hydroxymethyl)urea + NH4(+) => H2O + N-(aminomethyl)urea"}
{"X":17144,"RHEA_ID":13905,"DIRECTION":"UN","MASTER_ID":13905,"ec":"2.4.1.206","compounds":"a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine = a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP"}
{"X":17145,"RHEA_ID":13906,"compounds":"a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine => a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP"}
{"X":17146,"RHEA_ID":13907,"compounds":"a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":17147,"RHEA_ID":23724,"DIRECTION":"UN","MASTER_ID":23724,"ec":"1.2.3.8","compounds":"H2O + O2 + pyridoxal = 4-pyridoxate + H(+) + H2O2"}
{"X":17148,"RHEA_ID":13909,"DIRECTION":"UN","MASTER_ID":13909,"ec":"2.4.2.16","metacyc":"URATE-RIBONUCLEOTIDE-PHOSPHORYLASE-RXN","compounds":"phosphate + urate D-ribonucleoside = alpha-D-ribose 1-phosphate + urate"}
{"X":17149,"RHEA_ID":13910,"compounds":"phosphate + urate D-ribonucleoside => alpha-D-ribose 1-phosphate + urate"}
{"X":17150,"RHEA_ID":13911,"compounds":"alpha-D-ribose 1-phosphate + urate => phosphate + urate D-ribonucleoside"}
{"X":17151,"RHEA_ID":23728,"DIRECTION":"UN","MASTER_ID":23728,"ec":"1.14.99.1","compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = A + H2O + prostaglandin H2"}
{"X":17152,"RHEA_ID":13913,"DIRECTION":"UN","MASTER_ID":13913,"ec":"5.1.1.6","metacyc":"THREONINE-RACEMASE-RXN","compounds":"L-threonine = D-threonine"}
{"X":17153,"RHEA_ID":13914,"compounds":"L-threonine => D-threonine"}
{"X":17154,"RHEA_ID":13915,"compounds":"D-threonine => L-threonine"}
{"X":17155,"RHEA_ID":23732,"DIRECTION":"UN","MASTER_ID":23732,"ec":"4.1.1.33","compounds":"(R)-5-diphosphomevalonate + ATP = ADP + CO2 + isopentenyl diphosphate + phosphate"}
{"X":17156,"RHEA_ID":13917,"DIRECTION":"UN","MASTER_ID":13917,"ec":"1.1.1.207","compounds":"(-)-menthol + NADP(+) = (1R,4S)-menthone + H(+) + NADPH"}
{"X":17157,"RHEA_ID":13918,"compounds":"(-)-menthol + NADP(+) => (1R,4S)-menthone + H(+) + NADPH"}
{"X":17158,"RHEA_ID":13919,"DIRECTION":"RL","MASTER_ID":13917,"metacyc":"--MENTHOL-DEHYDROGENASE-RXN","compounds":"(1R,4S)-menthone + H(+) + NADPH => (-)-menthol + NADP(+)"}
{"X":17159,"RHEA_ID":23736,"DIRECTION":"UN","MASTER_ID":23736,"ec":"3.5.2.17","compounds":"5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)"}
{"X":17160,"RHEA_ID":13925,"DIRECTION":"UN","MASTER_ID":13925,"ec":"2.3.1.129","compounds":"(3R)-hydroxytetradecanoyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine = holo-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine"}
{"X":17161,"RHEA_ID":13926,"DIRECTION":"LR","MASTER_ID":13925,"ecocyc":"UDPNACETYLGLUCOSAMACYLTRANS-RXN","metacyc":"UDPNACETYLGLUCOSAMACYLTRANS-RXN","compounds":"(3R)-hydroxytetradecanoyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine => holo-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine"}
{"X":17162,"RHEA_ID":13927,"compounds":"holo-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine => (3R)-hydroxytetradecanoyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":17163,"RHEA_ID":23740,"compounds":"4-hydroxyphenylacetonitrile + H(+) + NADPH + O2 = 4-hydroxymandelonitrile + H2O + NADP(+)"}
{"X":17164,"RHEA_ID":13929,"DIRECTION":"UN","MASTER_ID":13929,"ec":"3.5.3.11","compounds":"agmatine + H2O = putrescine + urea"}
{"X":17165,"RHEA_ID":13930,"DIRECTION":"LR","MASTER_ID":13929,"ecocyc":"AGMATIN-RXN","reactome":"R-HSA-350604.1","compounds":"agmatine + H2O => putrescine + urea"}
{"X":17166,"RHEA_ID":13931,"compounds":"putrescine + urea => agmatine + H2O"}
{"X":17167,"RHEA_ID":13933,"compounds":"all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + H(+) + hexadecanoate"}
{"X":17168,"RHEA_ID":13934,"DIRECTION":"LR","MASTER_ID":13933,"metacyc":"3.1.1.64-RXN","reactome":"R-HSA-8848355.3","compounds":"all-trans-retinyl hexadecanoate + H2O => all-trans-retinol + H(+) + hexadecanoate"}
{"X":17169,"RHEA_ID":13935,"compounds":"all-trans-retinol + H(+) + hexadecanoate => all-trans-retinyl hexadecanoate + H2O"}
{"X":17170,"RHEA_ID":23748,"compounds":"ATP + GTP = diphosphate + pppGp(2'-5')A"}
{"X":17171,"RHEA_ID":13937,"DIRECTION":"UN","MASTER_ID":13937,"ec":"1.14.12.8","compounds":"4-sulfobenzoate + NADH + O2 = 3,4-dihydroxybenzoate + NAD(+) + sulfite"}
{"X":17172,"RHEA_ID":13938,"DIRECTION":"LR","MASTER_ID":13937,"metacyc":"4-SULFOBENZOATE-34-DIOXYGENASE-RXN","compounds":"4-sulfobenzoate + NADH + O2 => 3,4-dihydroxybenzoate + NAD(+) + sulfite"}
{"X":17173,"RHEA_ID":13939,"compounds":"3,4-dihydroxybenzoate + NAD(+) + sulfite => 4-sulfobenzoate + NADH + O2"}
{"X":17174,"RHEA_ID":23752,"DIRECTION":"UN","MASTER_ID":23752,"ec":"2.7.1.66","compounds":"all-trans-undecaprenol + ATP = ADP + all-trans-undecaprenyl phosphate + H(+)"}
{"X":17175,"RHEA_ID":13941,"DIRECTION":"UN","MASTER_ID":13941,"ec":"2.7.1.28","compounds":"ATP + D-glyceraldehyde = ADP + D-glyceraldehyde 3-phosphate + H(+)"}
{"X":17176,"RHEA_ID":13942,"DIRECTION":"LR","MASTER_ID":13941,"metacyc":"TRIOKINASE-RXN","reactome":"R-HSA-70349.4","compounds":"ATP + D-glyceraldehyde => ADP + D-glyceraldehyde 3-phosphate + H(+)"}
{"X":17177,"RHEA_ID":13943,"compounds":"ADP + D-glyceraldehyde 3-phosphate + H(+) => ATP + D-glyceraldehyde"}
{"X":17178,"RHEA_ID":23756,"DIRECTION":"UN","MASTER_ID":23756,"ec":"1.1.3.37","compounds":"D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H(+) + H2O2"}
{"X":17179,"RHEA_ID":13945,"DIRECTION":"UN","MASTER_ID":13945,"ec":"5.1.2.2","compounds":"(S)-mandelate = (R)-mandelate"}
{"X":17180,"RHEA_ID":13946,"DIRECTION":"LR","MASTER_ID":13945,"macie":"M0187","compounds":"(S)-mandelate => (R)-mandelate"}
{"X":17181,"RHEA_ID":13947,"DIRECTION":"RL","MASTER_ID":13945,"metacyc":"MANDELATE-RACEMASE-RXN","compounds":"(R)-mandelate => (S)-mandelate"}
{"X":17182,"RHEA_ID":23760,"DIRECTION":"UN","MASTER_ID":23760,"ec":"1.12.98.1","compounds":"H(+) + H2 + oxidized coenzyme F420-(gamma-Glu)(n) = reduced coenzyme F420-(gamma-Glu)(n)"}
{"X":17183,"RHEA_ID":13949,"DIRECTION":"UN","MASTER_ID":13949,"ec":"1.18.1.4","compounds":"H(+) + NADP(+) + 2 reduced [rubredoxin] = NADPH + 2 oxidized [rubredoxin]"}
{"X":17184,"RHEA_ID":13950,"compounds":"H(+) + NADP(+) + 2 reduced [rubredoxin] => NADPH + 2 oxidized [rubredoxin]"}
{"X":17185,"RHEA_ID":13951,"compounds":"NADPH + 2 oxidized [rubredoxin] => H(+) + NADP(+) + 2 reduced [rubredoxin]"}
{"X":17186,"RHEA_ID":13953,"DIRECTION":"UN","MASTER_ID":13953,"ec":"3.1.1.96","compounds":"a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + H(+) + tRNA"}
{"X":17187,"RHEA_ID":13954,"DIRECTION":"LR","MASTER_ID":13953,"ecocyc":"RXN-15041","metacyc":"RXN-15041","compounds":"a D-aminoacyl-tRNA + H2O => a D-alpha-amino acid + H(+) + tRNA"}
{"X":17188,"RHEA_ID":13955,"compounds":"a D-alpha-amino acid + H(+) + tRNA => a D-aminoacyl-tRNA + H2O"}
{"X":17189,"RHEA_ID":13956,"compounds":"a D-aminoacyl-tRNA + H2O <=> a D-alpha-amino acid + H(+) + tRNA"}
{"X":17190,"RHEA_ID":13957,"DIRECTION":"UN","MASTER_ID":13957,"ec":"1.13.11.55","compounds":"4 H2O + O2 + 4 sulfur = 6 H(+) + 2 hydrogen sulfide + 2 sulfite"}
{"X":17191,"RHEA_ID":13958,"DIRECTION":"LR","MASTER_ID":13957,"metacyc":"1.13.11.55-RXN","compounds":"4 H2O + O2 + 4 sulfur => 6 H(+) + 2 hydrogen sulfide + 2 sulfite"}
{"X":17192,"RHEA_ID":13959,"compounds":"6 H(+) + 2 hydrogen sulfide + 2 sulfite => 4 H2O + O2 + 4 sulfur"}
{"X":17193,"RHEA_ID":13961,"DIRECTION":"UN","MASTER_ID":13961,"ec":"6.6.1.1","compounds":"ATP + H2O + Mg(2+) + protoporphyrin IX = ADP + 3 H(+) + Mg-protoporphyrin IX + phosphate"}
{"X":17194,"RHEA_ID":13962,"DIRECTION":"LR","MASTER_ID":13961,"metacyc":"RXN1F-20","compounds":"ATP + H2O + Mg(2+) + protoporphyrin IX => ADP + 3 H(+) + Mg-protoporphyrin IX + phosphate"}
{"X":17195,"RHEA_ID":13963,"compounds":"ADP + 3 H(+) + Mg-protoporphyrin IX + phosphate => ATP + H2O + Mg(2+) + protoporphyrin IX"}
{"X":17196,"RHEA_ID":23776,"DIRECTION":"UN","MASTER_ID":23776,"ec":"2.7.2.4","compounds":"ATP + L-aspartate = 4-phospho-L-aspartate + ADP"}
{"X":17197,"RHEA_ID":13965,"DIRECTION":"UN","MASTER_ID":13965,"ec":"4.4.1.8","compounds":"H2O + L,L-cystathionine = L-homocysteine + NH4(+) + pyruvate"}
{"X":17198,"RHEA_ID":13966,"DIRECTION":"LR","MASTER_ID":13965,"ecocyc":"CYSTATHIONINE-BETA-LYASE-RXN","metacyc":"CYSTATHIONINE-BETA-LYASE-RXN","compounds":"H2O + L,L-cystathionine => L-homocysteine + NH4(+) + pyruvate"}
{"X":17199,"RHEA_ID":13967,"compounds":"L-homocysteine + NH4(+) + pyruvate => H2O + L,L-cystathionine"}
{"X":17200,"RHEA_ID":23780,"DIRECTION":"UN","MASTER_ID":23780,"ec":"2.3.3.5","compounds":"H2O + oxaloacetate + propanoyl-CoA = (2S,3S)-2-methylcitrate + CoA + H(+)"}
{"X":17201,"RHEA_ID":13969,"DIRECTION":"UN","MASTER_ID":13969,"ec":"6.5.1.5","compounds":"(RNA)-3'-(3'-phospho-ribonucleoside) + GTP = (RNA)-3'-(2',3'-cyclophospho)-ribonucleoside + diphosphate + GMP"}
{"X":17202,"RHEA_ID":13970,"DIRECTION":"LR","MASTER_ID":13969,"metacyc":"RXN-14708","compounds":"(RNA)-3'-(3'-phospho-ribonucleoside) + GTP => (RNA)-3'-(2',3'-cyclophospho)-ribonucleoside + diphosphate + GMP"}
{"X":17203,"RHEA_ID":13971,"compounds":"(RNA)-3'-(2',3'-cyclophospho)-ribonucleoside + diphosphate + GMP => (RNA)-3'-(3'-phospho-ribonucleoside) + GTP"}
{"X":17204,"RHEA_ID":23784,"DIRECTION":"UN","MASTER_ID":23784,"ec":"1.5.5.2","compounds":"a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)"}
{"X":17205,"RHEA_ID":13973,"DIRECTION":"UN","MASTER_ID":13973,"ec":"7.1.3.1","compounds":"diphosphate + H(+)(in) + H2O = 2 H(+)(out) + 2 phosphate"}
{"X":17206,"RHEA_ID":13974,"DIRECTION":"LR","MASTER_ID":13973,"metacyc":"TRANS-RXN-370","compounds":"diphosphate + H(+)(in) + H2O => 2 H(+)(out) + 2 phosphate"}
{"X":17207,"RHEA_ID":13975,"compounds":"2 H(+)(out) + 2 phosphate => diphosphate + H(+)(in) + H2O"}
{"X":17208,"RHEA_ID":13976,"compounds":"diphosphate + H(+)(in) + H2O <=> 2 H(+)(out) + 2 phosphate"}
{"X":17209,"RHEA_ID":13977,"DIRECTION":"UN","MASTER_ID":13977,"ec":"4.3.1.18","compounds":"D-serine = NH4(+) + pyruvate"}
{"X":17210,"RHEA_ID":13978,"DIRECTION":"LR","MASTER_ID":13977,"ecocyc":"DSERDEAM-RXN","metacyc":"DSERDEAM-RXN","reactome":"R-HSA-9014741.3","compounds":"D-serine => NH4(+) + pyruvate"}
{"X":17211,"RHEA_ID":13979,"compounds":"NH4(+) + pyruvate => D-serine"}
{"X":17212,"RHEA_ID":13981,"DIRECTION":"UN","MASTER_ID":13981,"ec":"1.2.2.4","metacyc":"1.2.2.4-RXN","compounds":"2 [Fe(III)-cytochrome b561] + CO + H2O = 2 [Fe(II)-cytochrome b561] + CO2 + 2 H(+)"}
{"X":17213,"RHEA_ID":13982,"compounds":"2 [Fe(III)-cytochrome b561] + CO + H2O => 2 [Fe(II)-cytochrome b561] + CO2 + 2 H(+)"}
{"X":17214,"RHEA_ID":13983,"compounds":"2 [Fe(II)-cytochrome b561] + CO2 + 2 H(+) => 2 [Fe(III)-cytochrome b561] + CO + H2O"}
{"X":17215,"RHEA_ID":13985,"DIRECTION":"UN","MASTER_ID":13985,"ec":"2.7.1.39","compounds":"ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine"}
{"X":17216,"RHEA_ID":13986,"compounds":"ATP + L-homoserine => ADP + H(+) + O-phospho-L-homoserine"}
{"X":17217,"RHEA_ID":13987,"compounds":"ADP + H(+) + O-phospho-L-homoserine => ATP + L-homoserine"}
{"X":17218,"RHEA_ID":34448,"compounds":"dTDP-6-deoxy-beta-L-talose + NAD(+) => dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADH"}
{"X":17219,"RHEA_ID":13989,"DIRECTION":"UN","MASTER_ID":13989,"ec":"2.7.7.12","compounds":"alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose"}
{"X":17220,"RHEA_ID":13990,"compounds":"alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose => alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose"}
{"X":17221,"RHEA_ID":13991,"compounds":"alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose => alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose"}
{"X":17222,"RHEA_ID":34452,"compounds":"dTDP-6-deoxy-beta-L-talose => dTDP-beta-L-rhamnose"}
{"X":17223,"RHEA_ID":13993,"DIRECTION":"UN","MASTER_ID":13993,"ec":"2.6.1.22","compounds":"(S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate"}
{"X":17224,"RHEA_ID":13994,"compounds":"(S)-3-amino-2-methylpropanoate + 2-oxoglutarate => 2-methyl-3-oxopropanoate + L-glutamate"}
{"X":17225,"RHEA_ID":13995,"DIRECTION":"RL","MASTER_ID":13993,"metacyc":"2.6.1.22-RXN","compounds":"2-methyl-3-oxopropanoate + L-glutamate => (S)-3-amino-2-methylpropanoate + 2-oxoglutarate"}
{"X":17226,"RHEA_ID":34456,"compounds":"all-trans-beta-carotene => 9-cis-beta-carotene"}
{"X":17227,"RHEA_ID":13997,"DIRECTION":"UN","MASTER_ID":13997,"ec":"1.2.1.25","compounds":"3-methyl-2-oxobutanoate + CoA + NAD(+) = 2-methylpropanoyl-CoA + CO2 + NADH"}
{"X":17228,"RHEA_ID":13998,"DIRECTION":"LR","MASTER_ID":13997,"metacyc":"1.2.1.25-RXN","compounds":"3-methyl-2-oxobutanoate + CoA + NAD(+) => 2-methylpropanoyl-CoA + CO2 + NADH"}
{"X":17229,"RHEA_ID":13999,"compounds":"2-methylpropanoyl-CoA + CO2 + NADH => 3-methyl-2-oxobutanoate + CoA + NAD(+)"}
{"X":17230,"RHEA_ID":34460,"DIRECTION":"LR","MASTER_ID":34459,"metacyc":"RXN-9454","compounds":"8-hydroxycopalyl diphosphate + H2O => diphosphate + sclareol"}
{"X":17231,"RHEA_ID":14001,"DIRECTION":"UN","MASTER_ID":14001,"ec":"2.3.1.65","compounds":"choloyl-CoA + glycine = CoA + glycocholate + H(+)"}
{"X":17232,"RHEA_ID":14002,"DIRECTION":"LR","MASTER_ID":14001,"metacyc":"GLYCINE-N-CHOLOYLTRANSFERASE-RXN","reactome":"R-HSA-192312.1","compounds":"choloyl-CoA + glycine => CoA + glycocholate + H(+)"}
{"X":17233,"RHEA_ID":14003,"compounds":"CoA + glycocholate + H(+) => choloyl-CoA + glycine"}
{"X":17234,"RHEA_ID":14005,"DIRECTION":"UN","MASTER_ID":14005,"ec":"4.4.1.1","compounds":"H2O + L,L-cystathionine = 2-oxobutanoate + L-cysteine + NH4(+)"}
{"X":17235,"RHEA_ID":14006,"DIRECTION":"LR","MASTER_ID":14005,"metacyc":"CYSTAGLY-RXN","reactome":"R-HSA-1614583.3","compounds":"H2O + L,L-cystathionine => 2-oxobutanoate + L-cysteine + NH4(+)"}
{"X":17236,"RHEA_ID":14007,"compounds":"2-oxobutanoate + L-cysteine + NH4(+) => H2O + L,L-cystathionine"}
{"X":17237,"RHEA_ID":34468,"DIRECTION":"LR","MASTER_ID":34467,"metacyc":"RXN-13769","compounds":"(2E,6E)-farnesyl diphosphate => diphosphate + valerena-4,7(11)-diene"}
{"X":17238,"RHEA_ID":14009,"DIRECTION":"UN","MASTER_ID":14009,"ec":"2.5.1.67","compounds":"2 dimethylallyl diphosphate = (R,R)-chrysanthemyl diphosphate + diphosphate"}
{"X":17239,"RHEA_ID":14010,"DIRECTION":"LR","MASTER_ID":14009,"metacyc":"2.5.1.67-RXN","compounds":"2 dimethylallyl diphosphate => (R,R)-chrysanthemyl diphosphate + diphosphate"}
{"X":17240,"RHEA_ID":14011,"compounds":"(R,R)-chrysanthemyl diphosphate + diphosphate => 2 dimethylallyl diphosphate"}
{"X":17241,"RHEA_ID":34472,"compounds":"NAD(+) + propanoyl-CoA => acryloyl-CoA + H(+) + NADH"}
{"X":17242,"RHEA_ID":14013,"DIRECTION":"UN","MASTER_ID":14013,"ec":"2.8.2.14","compounds":"3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate + H(+) + taurolithocholate sulfate"}
{"X":17243,"RHEA_ID":14014,"DIRECTION":"LR","MASTER_ID":14013,"reactome":"R-HSA-176604.2","compounds":"3'-phosphoadenylyl sulfate + taurolithocholate => adenosine 3',5'-bisphosphate + H(+) + taurolithocholate sulfate"}
{"X":17244,"RHEA_ID":14015,"compounds":"adenosine 3',5'-bisphosphate + H(+) + taurolithocholate sulfate => 3'-phosphoadenylyl sulfate + taurolithocholate"}
{"X":17245,"RHEA_ID":34476,"DIRECTION":"LR","MASTER_ID":34475,"metacyc":"RXN-13323","compounds":"2 all-trans-geranylgeranyl diphosphate => 15-cis-phytoene + 2 diphosphate"}
{"X":17246,"RHEA_ID":14017,"DIRECTION":"UN","MASTER_ID":14017,"ec":"2.7.1.22","compounds":"ATP + beta-nicotinamide D-riboside = ADP + beta-nicotinamide D-ribonucleotide + H(+)"}
{"X":17247,"RHEA_ID":14018,"DIRECTION":"LR","MASTER_ID":14017,"ecocyc":"RIBOSYLNICOTINAMIDE-KINASE-RXN","metacyc":"RIBOSYLNICOTINAMIDE-KINASE-RXN","reactome":"R-HSA-8869633.3","compounds":"ATP + beta-nicotinamide D-riboside => ADP + beta-nicotinamide D-ribonucleotide + H(+)"}
{"X":17248,"RHEA_ID":14018,"DIRECTION":"LR","MASTER_ID":14017,"ecocyc":"RIBOSYLNICOTINAMIDE-KINASE-RXN","metacyc":"RIBOSYLNICOTINAMIDE-KINASE-RXN","reactome":"R-HSA-8869627.3","compounds":"ATP + beta-nicotinamide D-riboside => ADP + beta-nicotinamide D-ribonucleotide + H(+)"}
{"X":17249,"RHEA_ID":14019,"compounds":"ADP + beta-nicotinamide D-ribonucleotide + H(+) => ATP + beta-nicotinamide D-riboside"}
{"X":17250,"RHEA_ID":23836,"DIRECTION":"UN","MASTER_ID":23836,"ec":"2.6.1.41","compounds":"D-methionine + pyruvate = 4-methylsulfanyl-2-oxobutanoate + L-alanine"}
{"X":17251,"RHEA_ID":14021,"DIRECTION":"UN","MASTER_ID":14021,"ec":"1.14.99.22","compounds":"AH2 + ecdysone + O2 = 20-hydroxyecdysone + A + H2O"}
{"X":17252,"RHEA_ID":14022,"DIRECTION":"LR","MASTER_ID":14021,"metacyc":"ECDYSONE-20-MONOOXYGENASE-RXN","compounds":"AH2 + ecdysone + O2 => 20-hydroxyecdysone + A + H2O"}
{"X":17253,"RHEA_ID":14023,"compounds":"20-hydroxyecdysone + A + H2O => AH2 + ecdysone + O2"}
{"X":17254,"RHEA_ID":23840,"DIRECTION":"UN","MASTER_ID":23840,"ec":"1.13.11.16","compounds":"3-(2,3-dihydroxyphenyl)propanoate + O2 = (2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H(+)"}
{"X":17255,"RHEA_ID":14025,"DIRECTION":"UN","MASTER_ID":14025,"ec":"3.5.4.24","metacyc":"SEPIAPTERIN-DEAMINASE-RXN","compounds":"H(+) + H2O + sepiapterin = NH4(+) + xanthopterin-B2"}
{"X":17256,"RHEA_ID":14026,"compounds":"H(+) + H2O + sepiapterin => NH4(+) + xanthopterin-B2"}
{"X":17257,"RHEA_ID":14027,"compounds":"NH4(+) + xanthopterin-B2 => H(+) + H2O + sepiapterin"}
{"X":17258,"RHEA_ID":23844,"DIRECTION":"UN","MASTER_ID":23844,"ec":"2.7.1.14","compounds":"ATP + sedoheptulose = ADP + D-sedoheptulose 7-phosphate + H(+)"}
{"X":17259,"RHEA_ID":14029,"DIRECTION":"UN","MASTER_ID":14029,"ec":"1.97.1.9","compounds":"A + H2O + selenite = AH2 + selenate"}
{"X":17260,"RHEA_ID":14030,"compounds":"A + H2O + selenite => AH2 + selenate"}
{"X":17261,"RHEA_ID":14031,"DIRECTION":"RL","MASTER_ID":14029,"ecocyc":"RXN0-2101","metacyc":"RXN0-2101","compounds":"AH2 + selenate => A + H2O + selenite"}
{"X":17262,"RHEA_ID":14033,"DIRECTION":"UN","MASTER_ID":14033,"ec":"3.1.4.43","compounds":"H2O + sn-glycero-3-phospho-1D-myo-inositol = 1D-myo-inositol 1-phosphate + glycerol + H(+)"}
{"X":17263,"RHEA_ID":14034,"DIRECTION":"LR","MASTER_ID":14033,"metacyc":"3.1.4.43-RXN","compounds":"H2O + sn-glycero-3-phospho-1D-myo-inositol => 1D-myo-inositol 1-phosphate + glycerol + H(+)"}
{"X":17264,"RHEA_ID":14035,"compounds":"1D-myo-inositol 1-phosphate + glycerol + H(+) => H2O + sn-glycero-3-phospho-1D-myo-inositol"}
{"X":17265,"RHEA_ID":23856,"DIRECTION":"UN","MASTER_ID":23856,"ec":"1.16.1.1","compounds":"H(+) + Hg + NADP(+) = Hg(2+) + NADPH"}
{"X":17266,"RHEA_ID":14037,"DIRECTION":"UN","MASTER_ID":14037,"ec":"1.3.1.3","compounds":"4,5beta-dihydrocortisone + NADP(+) = cortisone + H(+) + NADPH"}
{"X":17267,"RHEA_ID":14038,"compounds":"4,5beta-dihydrocortisone + NADP(+) => cortisone + H(+) + NADPH"}
{"X":17268,"RHEA_ID":14039,"compounds":"cortisone + H(+) + NADPH => 4,5beta-dihydrocortisone + NADP(+)"}
{"X":17269,"RHEA_ID":23860,"DIRECTION":"UN","MASTER_ID":23860,"ec":"2.3.1.175","compounds":"acetyl-CoA + deacetylcephalosporin C = cephalosporin C + CoA"}
{"X":17270,"RHEA_ID":14041,"DIRECTION":"UN","MASTER_ID":14041,"ec":"3.2.1.119","compounds":"(R)-vicianin + H2O = mandelonitrile + vicianose"}
{"X":17271,"RHEA_ID":14042,"DIRECTION":"LR","MASTER_ID":14041,"metacyc":"VICIANIN-BETA-GLUCOSIDASE-RXN","compounds":"(R)-vicianin + H2O => mandelonitrile + vicianose"}
{"X":17272,"RHEA_ID":14043,"compounds":"mandelonitrile + vicianose => (R)-vicianin + H2O"}
{"X":17273,"RHEA_ID":23864,"DIRECTION":"UN","MASTER_ID":23864,"ec":"4.6.1.12","compounds":"4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP"}
{"X":17274,"RHEA_ID":14045,"DIRECTION":"UN","MASTER_ID":14045,"ec":"2.7.8.23","compounds":"1-carboxyvinyl carboxyphosphonate + H(+) = 3-(hydrohydroxyphosphoryl)pyruvate + CO2"}
{"X":17275,"RHEA_ID":14046,"compounds":"1-carboxyvinyl carboxyphosphonate + H(+) => 3-(hydrohydroxyphosphoryl)pyruvate + CO2"}
{"X":17276,"RHEA_ID":14047,"compounds":"3-(hydrohydroxyphosphoryl)pyruvate + CO2 => 1-carboxyvinyl carboxyphosphonate + H(+)"}
{"X":17277,"RHEA_ID":23868,"DIRECTION":"UN","MASTER_ID":23868,"ec":"4.1.3.35","metacyc":"4.1.3.35-RXN","compounds":"(1-hydroxycyclohexan-1-yl)acetyl-CoA = acetyl-CoA + cyclohexanone"}
{"X":17278,"RHEA_ID":14049,"DIRECTION":"UN","MASTER_ID":14049,"ec":"1.14.99.37","compounds":"AH2 + O2 + taxa-4,11-diene = A + H2O + taxa-4(20),11-dien-5alpha-ol"}
{"X":17279,"RHEA_ID":14050,"DIRECTION":"LR","MASTER_ID":14049,"metacyc":"1.14.99.37-RXN","compounds":"AH2 + O2 + taxa-4,11-diene => A + H2O + taxa-4(20),11-dien-5alpha-ol"}
{"X":17280,"RHEA_ID":14051,"compounds":"A + H2O + taxa-4(20),11-dien-5alpha-ol => AH2 + O2 + taxa-4,11-diene"}
{"X":17281,"RHEA_ID":23872,"DIRECTION":"UN","MASTER_ID":23872,"ec":"1.1.1.77","compounds":"(R)-propane-1,2-diol + NAD(+) = (R)-lactaldehyde + H(+) + NADH"}
{"X":17282,"RHEA_ID":14053,"DIRECTION":"UN","MASTER_ID":14053,"ec":"2.5.1.55","compounds":"D-arabinose 5-phosphate + H2O + phosphoenolpyruvate = 3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + phosphate"}
{"X":17283,"RHEA_ID":14054,"DIRECTION":"LR","MASTER_ID":14053,"ecocyc":"KDO-8PSYNTH-RXN","metacyc":"KDO-8PSYNTH-RXN","compounds":"D-arabinose 5-phosphate + H2O + phosphoenolpyruvate => 3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + phosphate"}
{"X":17284,"RHEA_ID":14055,"compounds":"3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + phosphate => D-arabinose 5-phosphate + H2O + phosphoenolpyruvate"}
{"X":17285,"RHEA_ID":23876,"DIRECTION":"UN","MASTER_ID":23876,"ec":"4.2.1.73","metacyc":"4.2.1.73-RXN","compounds":"protoaphin aglucone = H2O + xanthoaphin"}
{"X":17286,"RHEA_ID":14057,"DIRECTION":"UN","MASTER_ID":14057,"ec":"2.3.1.158","compounds":"a 1,2-diacyl-sn-glycerol + a glycerophospholipid = a monoacylglycerophospholipid + a triacyl-sn-glycerol"}
{"X":17287,"RHEA_ID":14058,"compounds":"a 1,2-diacyl-sn-glycerol + a glycerophospholipid => a monoacylglycerophospholipid + a triacyl-sn-glycerol"}
{"X":17288,"RHEA_ID":14059,"compounds":"a monoacylglycerophospholipid + a triacyl-sn-glycerol => a 1,2-diacyl-sn-glycerol + a glycerophospholipid"}
{"X":17289,"RHEA_ID":14061,"DIRECTION":"UN","MASTER_ID":14061,"ec":"1.5.1.22","compounds":"H2O + N-(carboxymethyl)-D-alanine + NAD(+) = glycine + H(+) + NADH + pyruvate"}
{"X":17290,"RHEA_ID":14062,"compounds":"H2O + N-(carboxymethyl)-D-alanine + NAD(+) => glycine + H(+) + NADH + pyruvate"}
{"X":17291,"RHEA_ID":14063,"DIRECTION":"RL","MASTER_ID":14061,"metacyc":"STROMBINE-DEHYDROGENASE-RXN","compounds":"glycine + H(+) + NADH + pyruvate => H2O + N-(carboxymethyl)-D-alanine + NAD(+)"}
{"X":17292,"RHEA_ID":23884,"DIRECTION":"UN","MASTER_ID":23884,"ec":"2.1.1.1","compounds":"nicotinamide + S-adenosyl-L-methionine = 1-methylnicotinamide + S-adenosyl-L-homocysteine"}
{"X":17293,"RHEA_ID":14065,"DIRECTION":"UN","MASTER_ID":14065,"ec":"4.2.1.44","compounds":"scyllo-inosose = 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O"}
{"X":17294,"RHEA_ID":14066,"DIRECTION":"LR","MASTER_ID":14065,"metacyc":"MYO-INOSOSE-2-DEHYDRATASE-RXN","compounds":"scyllo-inosose => 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O"}
{"X":17295,"RHEA_ID":14067,"compounds":"3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O => scyllo-inosose"}
{"X":17296,"RHEA_ID":23888,"DIRECTION":"UN","MASTER_ID":23888,"ec":"6.3.2.30","compounds":"[L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ATP + L-arginine = [L-4-(L-arginin-2-N-yl)aspartate](n+1) + ADP + H(+) + phosphate"}
{"X":17297,"RHEA_ID":14069,"DIRECTION":"UN","MASTER_ID":14069,"ec":"1.1.1.124","compounds":"D-fructose + NADP(+) = 5-dehydro-D-fructose + H(+) + NADPH"}
{"X":17298,"RHEA_ID":14070,"compounds":"D-fructose + NADP(+) => 5-dehydro-D-fructose + H(+) + NADPH"}
{"X":17299,"RHEA_ID":14071,"compounds":"5-dehydro-D-fructose + H(+) + NADPH => D-fructose + NADP(+)"}
{"X":17300,"RHEA_ID":23892,"DIRECTION":"UN","MASTER_ID":23892,"ec":"1.3.1.16","metacyc":"BETA-NITROACRYLATE-REDUCTASE-RXN","compounds":"3-nitropropanoate + NADP(+) = 3-nitroacrylate + H(+) + NADPH"}
{"X":17301,"RHEA_ID":14073,"DIRECTION":"UN","MASTER_ID":14073,"ec":"4.1.1.16","metacyc":"HYDROXYGLUTAMATE-DECARBOXYLASE-RXN","compounds":"3-hydroxy-L-glutamate + H(+) = 4-amino-3-hydroxybutanoate + CO2"}
{"X":17302,"RHEA_ID":14074,"compounds":"3-hydroxy-L-glutamate + H(+) => 4-amino-3-hydroxybutanoate + CO2"}
{"X":17303,"RHEA_ID":14075,"compounds":"4-amino-3-hydroxybutanoate + CO2 => 3-hydroxy-L-glutamate + H(+)"}
{"X":17304,"RHEA_ID":23896,"DIRECTION":"UN","MASTER_ID":23896,"ec":"5.3.1.17","compounds":"5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate"}
{"X":17305,"RHEA_ID":14077,"DIRECTION":"UN","MASTER_ID":14077,"ec":"2.6.1.18","compounds":"3-oxopropanoate + L-alanine = beta-alanine + pyruvate"}
{"X":17306,"RHEA_ID":14078,"compounds":"3-oxopropanoate + L-alanine => beta-alanine + pyruvate"}
{"X":17307,"RHEA_ID":14079,"DIRECTION":"RL","MASTER_ID":14077,"reactome":"R-HSA-909776.1","compounds":"beta-alanine + pyruvate => 3-oxopropanoate + L-alanine"}
{"X":17308,"RHEA_ID":14081,"DIRECTION":"UN","MASTER_ID":14081,"ec":"4.1.2.8","compounds":"(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = D-glyceraldehyde 3-phosphate + indole"}
{"X":17309,"RHEA_ID":14082,"compounds":"(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate => D-glyceraldehyde 3-phosphate + indole"}
{"X":17310,"RHEA_ID":14083,"compounds":"D-glyceraldehyde 3-phosphate + indole => (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate"}
{"X":17311,"RHEA_ID":23904,"DIRECTION":"UN","MASTER_ID":23904,"ec":"2.3.2.2","compounds":"an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] = 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]"}
{"X":17312,"RHEA_ID":14085,"compounds":"(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA = 5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + diphosphate"}
{"X":17313,"RHEA_ID":14086,"DIRECTION":"LR","MASTER_ID":14085,"metacyc":"RXN-20755","compounds":"(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA => 5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + diphosphate"}
{"X":17314,"RHEA_ID":14087,"compounds":"5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + diphosphate => (2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA"}
{"X":17315,"RHEA_ID":14088,"compounds":"(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA <=> 5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + diphosphate"}
{"X":17316,"RHEA_ID":14089,"DIRECTION":"UN","MASTER_ID":14089,"ec":"2.6.1.4","compounds":"2-oxoglutarate + glycine = glyoxylate + L-glutamate"}
{"X":17317,"RHEA_ID":14090,"compounds":"2-oxoglutarate + glycine => glyoxylate + L-glutamate"}
{"X":17318,"RHEA_ID":14091,"compounds":"glyoxylate + L-glutamate => 2-oxoglutarate + glycine"}
{"X":17319,"RHEA_ID":23916,"DIRECTION":"UN","MASTER_ID":23916,"ec":"4.1.1.35","compounds":"H(+) + UDP-alpha-D-glucuronate = CO2 + UDP-alpha-D-xylose"}
{"X":17320,"RHEA_ID":14093,"DIRECTION":"UN","MASTER_ID":14093,"ec":"2.6.1.27","compounds":"2-oxoglutarate + L-tryptophan = indole-3-pyruvate + L-glutamate"}
{"X":17321,"RHEA_ID":14094,"compounds":"2-oxoglutarate + L-tryptophan => indole-3-pyruvate + L-glutamate"}
{"X":17322,"RHEA_ID":14095,"compounds":"indole-3-pyruvate + L-glutamate => 2-oxoglutarate + L-tryptophan"}
{"X":17323,"RHEA_ID":23920,"DIRECTION":"UN","MASTER_ID":23920,"ec":"4.3.2.2","compounds":"(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate"}
{"X":17324,"RHEA_ID":14097,"DIRECTION":"UN","MASTER_ID":14097,"ec":"2.6.1.70","compounds":"3-phenylpyruvate + L-aspartate = L-phenylalanine + oxaloacetate"}
{"X":17325,"RHEA_ID":14098,"compounds":"3-phenylpyruvate + L-aspartate => L-phenylalanine + oxaloacetate"}
{"X":17326,"RHEA_ID":14099,"compounds":"L-phenylalanine + oxaloacetate => 3-phenylpyruvate + L-aspartate"}
{"X":17327,"RHEA_ID":23924,"compounds":"pppGp(2'-5')A = 2',3'-cGAMP + diphosphate"}
{"X":17328,"RHEA_ID":14101,"DIRECTION":"UN","MASTER_ID":14101,"ec":"1.14.99.29","compounds":"[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O"}
{"X":17329,"RHEA_ID":14102,"DIRECTION":"LR","MASTER_ID":14101,"metacyc":"DEOXYHYPUSINE-MONOOXYGENASE-RXN","compounds":"[eIF5A protein]-deoxyhypusine + AH2 + O2 => [eIF5A protein]-hypusine + A + H2O"}
{"X":17330,"RHEA_ID":14103,"compounds":"[eIF5A protein]-hypusine + A + H2O => [eIF5A protein]-deoxyhypusine + AH2 + O2"}
{"X":17331,"RHEA_ID":14105,"DIRECTION":"UN","MASTER_ID":14105,"ec":"1.5.1.2","compounds":"L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH"}
{"X":17332,"RHEA_ID":14106,"compounds":"L-proline + NAD(+) => 1-pyrroline-5-carboxylate + 2 H(+) + NADH"}
{"X":17333,"RHEA_ID":14107,"DIRECTION":"RL","MASTER_ID":14105,"ecocyc":"PYRROLINECARBREDUCT-RXN","metacyc":"PYRROLINECARBREDUCT-RXN","compounds":"1-pyrroline-5-carboxylate + 2 H(+) + NADH => L-proline + NAD(+)"}
{"X":17334,"RHEA_ID":23932,"DIRECTION":"UN","MASTER_ID":23932,"ec":"5.1.3.9","compounds":"an N-acyl-D-glucosamine 6-phosphate = an N-acyl-D-mannosamine 6-phosphate"}
{"X":17335,"RHEA_ID":14109,"DIRECTION":"UN","MASTER_ID":14109,"ec":"1.5.1.2","compounds":"L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH"}
{"X":17336,"RHEA_ID":14110,"compounds":"L-proline + NADP(+) => 1-pyrroline-5-carboxylate + 2 H(+) + NADPH"}
{"X":17337,"RHEA_ID":14111,"DIRECTION":"RL","MASTER_ID":14109,"ecocyc":"PYRROLINECARBREDUCT-RXN","metacyc":"PYRROLINECARBREDUCT-RXN","compounds":"1-pyrroline-5-carboxylate + 2 H(+) + NADPH => L-proline + NADP(+)"}
{"X":17338,"RHEA_ID":23936,"DIRECTION":"UN","MASTER_ID":23936,"ec":"1.1.1.69","compounds":"D-gluconate + NADP(+) = 5-dehydro-D-gluconate + H(+) + NADPH"}
{"X":17339,"RHEA_ID":14113,"DIRECTION":"UN","MASTER_ID":14113,"ec":"3.1.3.32","compounds":"(DNA)-3'-(deoxyribonucleoside 3',5'-bisphosphate) + H2O = (DNA)-3'-(deoxyribonucleoside 5'-phosphate) + phosphate"}
{"X":17340,"RHEA_ID":14114,"DIRECTION":"LR","MASTER_ID":14113,"metacyc":"POLYNUCLEOTIDE-3-PHOSPHATASE-RXN","compounds":"(DNA)-3'-(deoxyribonucleoside 3',5'-bisphosphate) + H2O => (DNA)-3'-(deoxyribonucleoside 5'-phosphate) + phosphate"}
{"X":17341,"RHEA_ID":14115,"compounds":"(DNA)-3'-(deoxyribonucleoside 5'-phosphate) + phosphate => (DNA)-3'-(deoxyribonucleoside 3',5'-bisphosphate) + H2O"}
{"X":17342,"RHEA_ID":14117,"DIRECTION":"UN","MASTER_ID":14117,"ec":"3.2.1.67","compounds":"[(1->4)-alpha-D-galacturonosyl](n) + H2O = [(1->4)-alpha-D-galacturonosyl](n-1) + alpha-D-galacturonate"}
{"X":17343,"RHEA_ID":14118,"DIRECTION":"LR","MASTER_ID":14117,"metacyc":"GALACTURAN-14-ALPHA-GALACTURONIDASE-RXN","compounds":"[(1->4)-alpha-D-galacturonosyl](n) + H2O => [(1->4)-alpha-D-galacturonosyl](n-1) + alpha-D-galacturonate"}
{"X":17344,"RHEA_ID":14119,"compounds":"[(1->4)-alpha-D-galacturonosyl](n-1) + alpha-D-galacturonate => [(1->4)-alpha-D-galacturonosyl](n) + H2O"}
{"X":17345,"RHEA_ID":14121,"DIRECTION":"UN","MASTER_ID":14121,"ec":"2.1.1.114","compounds":"3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine"}
{"X":17346,"RHEA_ID":14122,"DIRECTION":"LR","MASTER_ID":14121,"metacyc":"2.1.1.114-RXN","compounds":"3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + S-adenosyl-L-methionine => 3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine"}
{"X":17347,"RHEA_ID":14123,"compounds":"3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine => 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + S-adenosyl-L-methionine"}
{"X":17348,"RHEA_ID":23948,"DIRECTION":"UN","MASTER_ID":23948,"ec":"1.1.1.61","compounds":"4-hydroxybutanoate + NAD(+) = H(+) + NADH + succinate semialdehyde"}
{"X":17349,"RHEA_ID":14125,"DIRECTION":"UN","MASTER_ID":14125,"ec":"2.4.1.166","compounds":"2 raffinose = 1(F)-alpha-D-galactosylraffinose + sucrose"}
{"X":17350,"RHEA_ID":14126,"DIRECTION":"LR","MASTER_ID":14125,"metacyc":"2.4.1.166-RXN","compounds":"2 raffinose => 1(F)-alpha-D-galactosylraffinose + sucrose"}
{"X":17351,"RHEA_ID":14127,"compounds":"1(F)-alpha-D-galactosylraffinose + sucrose => 2 raffinose"}
{"X":17352,"RHEA_ID":23952,"DIRECTION":"UN","MASTER_ID":23952,"ec":"3.5.1.76","compounds":"H2O + N-(2-phenylethyl)acetamide = 2-phenylethylamine + acetate"}
{"X":17353,"RHEA_ID":14129,"DIRECTION":"UN","MASTER_ID":14129,"ec":"1.1.1.176","compounds":"cholate + NADP(+) = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH"}
{"X":17354,"RHEA_ID":14130,"compounds":"cholate + NADP(+) => 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH"}
{"X":17355,"RHEA_ID":14131,"compounds":"3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH => cholate + NADP(+)"}
{"X":17356,"RHEA_ID":23956,"DIRECTION":"UN","MASTER_ID":23956,"ec":"2.4.1.41","compounds":"L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP"}
{"X":17357,"RHEA_ID":14133,"DIRECTION":"UN","MASTER_ID":14133,"ec":"1.14.14.103","compounds":"(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] = 16-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":17358,"RHEA_ID":14134,"DIRECTION":"LR","MASTER_ID":14133,"metacyc":"1.14.13.73-RXN","compounds":"(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] => 16-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":17359,"RHEA_ID":14135,"compounds":"16-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":17360,"RHEA_ID":14137,"DIRECTION":"UN","MASTER_ID":14137,"ec":"2.8.2.13","compounds":"3'-phosphoadenylyl sulfate + beta-D-galactosyl-(1<->1)-sphing-4-enine = 6-O-sulfo-beta-D-galactosyl-(1<->1)-sphing-4-enine + adenosine 3',5'-bisphosphate + H(+)"}
{"X":17361,"RHEA_ID":14138,"DIRECTION":"LR","MASTER_ID":14137,"metacyc":"PSYCHOSINE-SULFOTRANSFERASE-RXN","compounds":"3'-phosphoadenylyl sulfate + beta-D-galactosyl-(1<->1)-sphing-4-enine => 6-O-sulfo-beta-D-galactosyl-(1<->1)-sphing-4-enine + adenosine 3',5'-bisphosphate + H(+)"}
{"X":17362,"RHEA_ID":14139,"compounds":"6-O-sulfo-beta-D-galactosyl-(1<->1)-sphing-4-enine + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + beta-D-galactosyl-(1<->1)-sphing-4-enine"}
{"X":17363,"RHEA_ID":34599,"compounds":"15-methylhexadecasphinganine + NADP(+) = 3-dehydro-15-methylhexadecasphinganine + H(+) + NADPH"}
{"X":17364,"RHEA_ID":14141,"DIRECTION":"UN","MASTER_ID":14141,"ec":"1.8.4.9","compounds":"AMP + glutathione disulfide + 2 H(+) + sulfite = adenosine 5'-phosphosulfate + 2 glutathione"}
{"X":17365,"RHEA_ID":14142,"compounds":"AMP + glutathione disulfide + 2 H(+) + sulfite => adenosine 5'-phosphosulfate + 2 glutathione"}
{"X":17366,"RHEA_ID":14143,"DIRECTION":"RL","MASTER_ID":14141,"metacyc":"1.8.4.9-RXN","compounds":"adenosine 5'-phosphosulfate + 2 glutathione => AMP + glutathione disulfide + 2 H(+) + sulfite"}
{"X":17367,"RHEA_ID":34603,"compounds":"15-methylhexadecasphinganine + an acyl-CoA = CoA + H(+) + N-acyl-15-methylhexadecasphinganine"}
{"X":17368,"RHEA_ID":14145,"DIRECTION":"UN","MASTER_ID":14145,"ec":"2.7.3.1","compounds":"ATP + guanidinoacetate = ADP + H(+) + phosphoguanidinoacetate"}
{"X":17369,"RHEA_ID":14146,"compounds":"ATP + guanidinoacetate => ADP + H(+) + phosphoguanidinoacetate"}
{"X":17370,"RHEA_ID":14147,"compounds":"ADP + H(+) + phosphoguanidinoacetate => ATP + guanidinoacetate"}
{"X":17371,"RHEA_ID":34607,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-15-methylhexadecasphing-4-enine = a 1,2-diacyl-sn-glycerol + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine"}
{"X":17372,"RHEA_ID":14149,"DIRECTION":"UN","MASTER_ID":14149,"ec":"2.4.1.190","compounds":"luteolin 7-O-beta-D-glucuronide + UDP-alpha-D-glucuronate = H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP"}
{"X":17373,"RHEA_ID":14150,"DIRECTION":"LR","MASTER_ID":14149,"metacyc":"2.4.1.190-RXN","compounds":"luteolin 7-O-beta-D-glucuronide + UDP-alpha-D-glucuronate => H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP"}
{"X":17374,"RHEA_ID":14151,"compounds":"H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP => luteolin 7-O-beta-D-glucuronide + UDP-alpha-D-glucuronate"}
{"X":17375,"RHEA_ID":34611,"compounds":"N-acyl-15-methylhexadecasphing-4-enine + UDP-alpha-D-glucose = H(+) + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine + UDP"}
{"X":17376,"RHEA_ID":14153,"DIRECTION":"UN","MASTER_ID":14153,"ec":"2.4.1.39","metacyc":"2.4.1.39-RXN","compounds":"17alpha-estradiol 3-O-(beta-D-glucuronate) + UDP-N-acetyl-alpha-D-glucosamine = 17alpha-(N-acetyl-alpha-D-glucosaminyl)estradiol 3-glucosiduronate + H(+) + UDP"}
{"X":17377,"RHEA_ID":14154,"compounds":"17alpha-estradiol 3-O-(beta-D-glucuronate) + UDP-N-acetyl-alpha-D-glucosamine => 17alpha-(N-acetyl-alpha-D-glucosaminyl)estradiol 3-glucosiduronate + H(+) + UDP"}
{"X":17378,"RHEA_ID":14155,"compounds":"17alpha-(N-acetyl-alpha-D-glucosaminyl)estradiol 3-glucosiduronate + H(+) + UDP => 17alpha-estradiol 3-O-(beta-D-glucuronate) + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":17379,"RHEA_ID":34615,"DIRECTION":"UN","MASTER_ID":34615,"ec":"1.13.11.73","compounds":"2-hydroxyethylphosphonate + O2 = H(+) + hydrogencarbonate + methylphosphonate"}
{"X":17380,"RHEA_ID":14157,"DIRECTION":"UN","MASTER_ID":14157,"ec":"3.6.1.25","compounds":"H2O + triphosphate = diphosphate + phosphate"}
{"X":17381,"RHEA_ID":14158,"compounds":"H2O + triphosphate => diphosphate + phosphate"}
{"X":17382,"RHEA_ID":14159,"compounds":"diphosphate + phosphate => H2O + triphosphate"}
{"X":17383,"RHEA_ID":14161,"DIRECTION":"UN","MASTER_ID":14161,"ec":"1.13.11.53","compounds":"1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)"}
{"X":17384,"RHEA_ID":14162,"DIRECTION":"LR","MASTER_ID":14161,"metacyc":"R146-RXN","compounds":"1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 => 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)"}
{"X":17385,"RHEA_ID":14163,"compounds":"3-(methylsulfanyl)propanoate + CO + formate + 2 H(+) => 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2"}
{"X":17386,"RHEA_ID":23986,"compounds":"cholesta-5,7-dien-3beta-ol + H(+) + NADPH => cholesterol + NADP(+)"}
{"X":17387,"RHEA_ID":14165,"DIRECTION":"UN","MASTER_ID":14165,"ec":"2.3.1.17","compounds":"acetyl-CoA + L-aspartate = CoA + H(+) + N-acetyl-L-aspartate"}
{"X":17388,"RHEA_ID":14166,"DIRECTION":"LR","MASTER_ID":14165,"reactome":"R-HSA-8954468.1","compounds":"acetyl-CoA + L-aspartate => CoA + H(+) + N-acetyl-L-aspartate"}
{"X":17389,"RHEA_ID":14167,"compounds":"CoA + H(+) + N-acetyl-L-aspartate => acetyl-CoA + L-aspartate"}
{"X":17390,"RHEA_ID":23990,"compounds":"(S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O + L-glutamate => (2S,6S)-2,6-diaminoheptanedioate + 2-oxoglutarate"}
{"X":17391,"RHEA_ID":14169,"DIRECTION":"UN","MASTER_ID":14169,"ec":"6.2.1.6","compounds":"ATP + CoA + glutarate = ADP + glutaryl-CoA + phosphate"}
{"X":17392,"RHEA_ID":14170,"DIRECTION":"LR","MASTER_ID":14169,"metacyc":"GLUTARATE--COA-LIGASE-RXN","compounds":"ATP + CoA + glutarate => ADP + glutaryl-CoA + phosphate"}
{"X":17393,"RHEA_ID":14171,"compounds":"ADP + glutaryl-CoA + phosphate => ATP + CoA + glutarate"}
{"X":17394,"RHEA_ID":23994,"compounds":"1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA => 1-O-alkyl-sn-glycero-3-phosphocholine + an acyl-CoA"}
{"X":17395,"RHEA_ID":14173,"DIRECTION":"UN","MASTER_ID":14173,"ec":"2.5.1.34","compounds":"dimethylallyl diphosphate + L-tryptophan = 4-(3-methylbut-2-enyl)-L-tryptophan + diphosphate"}
{"X":17396,"RHEA_ID":14174,"DIRECTION":"LR","MASTER_ID":14173,"metacyc":"TRYPTOPHAN-DIMETHYLALLYLTRANSFERASE-RXN","compounds":"dimethylallyl diphosphate + L-tryptophan => 4-(3-methylbut-2-enyl)-L-tryptophan + diphosphate"}
{"X":17397,"RHEA_ID":14175,"compounds":"4-(3-methylbut-2-enyl)-L-tryptophan + diphosphate => dimethylallyl diphosphate + L-tryptophan"}
{"X":17398,"RHEA_ID":23998,"compounds":"a ribonucleoside 5'-phosphate + diphosphate + H(+) => a ribonucleoside 5'-triphosphate + H2O"}
{"X":17399,"RHEA_ID":14177,"DIRECTION":"UN","MASTER_ID":14177,"ec":"3.2.1.117","compounds":"(R)-amygdalin + H2O = (R)-prunasin + D-glucose"}
{"X":17400,"RHEA_ID":14178,"DIRECTION":"LR","MASTER_ID":14177,"metacyc":"AMYGDALIN-BETA-GLUCOSIDASE-RXN","compounds":"(R)-amygdalin + H2O => (R)-prunasin + D-glucose"}
{"X":17401,"RHEA_ID":14179,"compounds":"(R)-prunasin + D-glucose => (R)-amygdalin + H2O"}
{"X":17402,"RHEA_ID":24002,"compounds":"a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein] => a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein]"}
{"X":17403,"RHEA_ID":14181,"DIRECTION":"UN","MASTER_ID":14181,"ec":"1.14.11.8","compounds":"2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O2 = (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO2 + succinate"}
{"X":17404,"RHEA_ID":14182,"DIRECTION":"LR","MASTER_ID":14181,"metacyc":"TRIMETHYLLYSINE-DIOXYGENASE-RXN","compounds":"2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O2 => (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO2 + succinate"}
{"X":17405,"RHEA_ID":14183,"compounds":"(3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO2 + succinate => 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O2"}
{"X":17406,"RHEA_ID":24006,"DIRECTION":"RL","MASTER_ID":24004,"metacyc":"BUTYRYL-COA-DEHYDROGENASE-RXN","compounds":"(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] => butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":17407,"RHEA_ID":14185,"DIRECTION":"UN","MASTER_ID":14185,"ec":"4.1.1.43","compounds":"3-phenylpyruvate + H(+) = 2-phenylacetaldehyde + CO2"}
{"X":17408,"RHEA_ID":14186,"compounds":"3-phenylpyruvate + H(+) => 2-phenylacetaldehyde + CO2"}
{"X":17409,"RHEA_ID":14187,"compounds":"2-phenylacetaldehyde + CO2 => 3-phenylpyruvate + H(+)"}
{"X":17410,"RHEA_ID":24010,"compounds":"ADP + H(+) + N(omega)-phosphohypotaurocyamine => ATP + hypotaurocyamine"}
{"X":17411,"RHEA_ID":14189,"DIRECTION":"UN","MASTER_ID":14189,"ec":"1.13.11.52","compounds":"D-tryptophan + O2 = N-formyl-D-kynurenine"}
{"X":17412,"RHEA_ID":14190,"DIRECTION":"LR","MASTER_ID":14189,"metacyc":"RXN-8664","compounds":"D-tryptophan + O2 => N-formyl-D-kynurenine"}
{"X":17413,"RHEA_ID":14191,"compounds":"N-formyl-D-kynurenine => D-tryptophan + O2"}
{"X":17414,"RHEA_ID":24014,"compounds":"(+)-alpha-tocopherol + H(+) + S-adenosyl-L-homocysteine => gamma-tocopherol + S-adenosyl-L-methionine"}
{"X":17415,"RHEA_ID":14193,"DIRECTION":"UN","MASTER_ID":14193,"ec":"1.14.99.23","compounds":"3-hydroxybenzoate + AH2 + O2 = 2,3-dihydroxybenzoate + A + H2O"}
{"X":17416,"RHEA_ID":14194,"DIRECTION":"LR","MASTER_ID":14193,"metacyc":"3-HYDROXYBENZOATE-2-MONOOXYGENASE-RXN","compounds":"3-hydroxybenzoate + AH2 + O2 => 2,3-dihydroxybenzoate + A + H2O"}
{"X":17417,"RHEA_ID":14195,"compounds":"2,3-dihydroxybenzoate + A + H2O => 3-hydroxybenzoate + AH2 + O2"}
{"X":17418,"RHEA_ID":24018,"compounds":"CoA + vinorine => 16-epivellosimine + acetyl-CoA"}
{"X":17419,"RHEA_ID":14197,"DIRECTION":"UN","MASTER_ID":14197,"ec":"6.3.1.4","compounds":"ATP + L-aspartate + NH4(+) = ADP + H(+) + L-asparagine + phosphate"}
{"X":17420,"RHEA_ID":14198,"DIRECTION":"LR","MASTER_ID":14197,"metacyc":"6.3.1.4-RXN","compounds":"ATP + L-aspartate + NH4(+) => ADP + H(+) + L-asparagine + phosphate"}
{"X":17421,"RHEA_ID":14199,"compounds":"ADP + H(+) + L-asparagine + phosphate => ATP + L-aspartate + NH4(+)"}
{"X":17422,"RHEA_ID":24022,"compounds":"fumarate + L-arginine => 2-(N(omega)-L-arginino)succinate"}
{"X":17423,"RHEA_ID":14201,"DIRECTION":"UN","MASTER_ID":14201,"ec":"5.3.1.15","compounds":"D-lyxose = D-xylulose"}
{"X":17424,"RHEA_ID":14202,"compounds":"D-lyxose => D-xylulose"}
{"X":17425,"RHEA_ID":14203,"compounds":"D-xylulose => D-lyxose"}
{"X":17426,"RHEA_ID":24026,"compounds":"(2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + L-alanine => (2E,5S,6E,8E,10E)-1-aminododeca-2,6,8,10-tetraen-5-ol + pyruvate"}
{"X":17427,"RHEA_ID":14205,"DIRECTION":"UN","MASTER_ID":14205,"ec":"2.1.1.22","compounds":"carnosine + S-adenosyl-L-methionine = anserine + H(+) + S-adenosyl-L-homocysteine"}
{"X":17428,"RHEA_ID":14206,"DIRECTION":"LR","MASTER_ID":14205,"metacyc":"CARNOSINE-N-METHYLTRANSFERASE-RXN","reactome":"R-HSA-8876789.1","compounds":"carnosine + S-adenosyl-L-methionine => anserine + H(+) + S-adenosyl-L-homocysteine"}
{"X":17429,"RHEA_ID":14207,"compounds":"anserine + H(+) + S-adenosyl-L-homocysteine => carnosine + S-adenosyl-L-methionine"}
{"X":17430,"RHEA_ID":24030,"compounds":"carnitine + CO2 + succinate => 2-oxoglutarate + 4-(trimethylamino)butanoate + O2"}
{"X":17431,"RHEA_ID":14209,"DIRECTION":"UN","MASTER_ID":14209,"ec":"2.7.7.10","compounds":"alpha-D-galactose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-galactose"}
{"X":17432,"RHEA_ID":14210,"compounds":"alpha-D-galactose 1-phosphate + H(+) + UTP => diphosphate + UDP-alpha-D-galactose"}
{"X":17433,"RHEA_ID":14211,"compounds":"diphosphate + UDP-alpha-D-galactose => alpha-D-galactose 1-phosphate + H(+) + UTP"}
{"X":17434,"RHEA_ID":24034,"compounds":"6-O-alpha-D-glucopyranosyl-D-fructose => sucrose"}
{"X":17435,"RHEA_ID":14213,"DIRECTION":"UN","MASTER_ID":14213,"ec":"2.7.1.56","compounds":"ATP + beta-D-fructose 1-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)"}
{"X":17436,"RHEA_ID":14214,"DIRECTION":"LR","MASTER_ID":14213,"ecocyc":"1PFRUCTPHOSN-RXN","metacyc":"1PFRUCTPHOSN-RXN","compounds":"ATP + beta-D-fructose 1-phosphate => ADP + beta-D-fructose 1,6-bisphosphate + H(+)"}
{"X":17437,"RHEA_ID":14215,"compounds":"ADP + beta-D-fructose 1,6-bisphosphate + H(+) => ATP + beta-D-fructose 1-phosphate"}
{"X":17438,"RHEA_ID":24038,"compounds":"a ribonucleoside 5'-diphosphate + ADP => a ribonucleoside 5'-phosphate + ATP"}
{"X":17439,"RHEA_ID":14217,"DIRECTION":"UN","MASTER_ID":14217,"ec":"1.8.4.11","compounds":"[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]"}
{"X":17440,"RHEA_ID":14218,"compounds":"[thioredoxin]-disulfide + H2O + L-methionyl-[protein] => [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]"}
{"X":17441,"RHEA_ID":14219,"DIRECTION":"RL","MASTER_ID":14217,"ecocyc":"RXN-8668","metacyc":"RXN-8668","compounds":"[thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein] => [thioredoxin]-disulfide + H2O + L-methionyl-[protein]"}
{"X":17442,"RHEA_ID":14221,"DIRECTION":"UN","MASTER_ID":14221,"ec":"3.1.6.16","compounds":"H2O + monomethyl sulfate = H(+) + methanol + sulfate"}
{"X":17443,"RHEA_ID":14222,"DIRECTION":"LR","MASTER_ID":14221,"metacyc":"MONOMETHYL-SULFATASE-RXN","compounds":"H2O + monomethyl sulfate => H(+) + methanol + sulfate"}
{"X":17444,"RHEA_ID":14223,"compounds":"H(+) + methanol + sulfate => H2O + monomethyl sulfate"}
{"X":17445,"RHEA_ID":14225,"DIRECTION":"UN","MASTER_ID":14225,"ec":"1.1.1.258","compounds":"6-hydroxyhexanoate + NAD(+) = 6-oxohexanoate + H(+) + NADH"}
{"X":17446,"RHEA_ID":14226,"DIRECTION":"LR","MASTER_ID":14225,"metacyc":"6-HYDROXYHEXANOATE-OXIDATION-RXN","compounds":"6-hydroxyhexanoate + NAD(+) => 6-oxohexanoate + H(+) + NADH"}
{"X":17447,"RHEA_ID":14227,"compounds":"6-oxohexanoate + H(+) + NADH => 6-hydroxyhexanoate + NAD(+)"}
{"X":17448,"RHEA_ID":24050,"compounds":"alpha-D-glucose 1-phosphate + D-fructose => phosphate + sucrose"}
{"X":17449,"RHEA_ID":14229,"DIRECTION":"UN","MASTER_ID":14229,"ec":"1.5.7.1","compounds":"(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 2 oxidized [2Fe-2S]-[ferredoxin] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":17450,"RHEA_ID":14230,"compounds":"(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 2 oxidized [2Fe-2S]-[ferredoxin] => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":17451,"RHEA_ID":14231,"DIRECTION":"RL","MASTER_ID":14229,"metacyc":"RXN-5061","compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":17452,"RHEA_ID":24054,"compounds":"a ubiquinol + H(+) + oxidized [electron-transfer flavoprotein] => a ubiquinone + reduced [electron-transfer flavoprotein]"}
{"X":17453,"RHEA_ID":14233,"DIRECTION":"UN","MASTER_ID":14233,"ec":"2.3.1.52","metacyc":"2-ACYL2.3.1.15-RXN","compounds":"a 2-acyl-sn-glycerol 3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA"}
{"X":17454,"RHEA_ID":14234,"compounds":"a 2-acyl-sn-glycerol 3-phosphate + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphate + CoA"}
{"X":17455,"RHEA_ID":14235,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphate + CoA => a 2-acyl-sn-glycerol 3-phosphate + an acyl-CoA"}
{"X":17456,"RHEA_ID":14237,"DIRECTION":"UN","MASTER_ID":14237,"ec":"1.14.14.136","compounds":"10-deoxysarpagine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sarpagine"}
{"X":17457,"RHEA_ID":14238,"DIRECTION":"LR","MASTER_ID":14237,"metacyc":"1.14.13.91-RXN","compounds":"10-deoxysarpagine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sarpagine"}
{"X":17458,"RHEA_ID":14239,"compounds":"H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sarpagine => 10-deoxysarpagine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":17459,"RHEA_ID":24062,"compounds":"H(+) + H2O + N,N-dihydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":17460,"RHEA_ID":14241,"compounds":"3-amino-4-hydroxybenzaldehyde + acetyl-CoA = 3-acetylamino-4-hydroxybenzaldehyde + CoA + H(+)"}
{"X":17461,"RHEA_ID":14242,"DIRECTION":"LR","MASTER_ID":14241,"metacyc":"RXN-13871","compounds":"3-amino-4-hydroxybenzaldehyde + acetyl-CoA => 3-acetylamino-4-hydroxybenzaldehyde + CoA + H(+)"}
{"X":17462,"RHEA_ID":14243,"compounds":"3-acetylamino-4-hydroxybenzaldehyde + CoA + H(+) => 3-amino-4-hydroxybenzaldehyde + acetyl-CoA"}
{"X":17463,"RHEA_ID":14244,"compounds":"3-amino-4-hydroxybenzaldehyde + acetyl-CoA <=> 3-acetylamino-4-hydroxybenzaldehyde + CoA + H(+)"}
{"X":17464,"RHEA_ID":14245,"DIRECTION":"UN","MASTER_ID":14245,"ec":"3.6.1.8","compounds":"ATP + H2O = AMP + diphosphate + H(+)"}
{"X":17465,"RHEA_ID":14245,"DIRECTION":"UN","MASTER_ID":14245,"ec":"3.6.1.9","compounds":"ATP + H2O = AMP + diphosphate + H(+)"}
{"X":17466,"RHEA_ID":14246,"DIRECTION":"LR","MASTER_ID":14245,"ecocyc":"ATP-PYROPHOSPHATASE-RXN","metacyc":"ATP-PYROPHOSPHATASE-RXN","compounds":"ATP + H2O => AMP + diphosphate + H(+)"}
{"X":17467,"RHEA_ID":14247,"compounds":"AMP + diphosphate + H(+) => ATP + H2O"}
{"X":17468,"RHEA_ID":34712,"compounds":"H2O + N-acyl-15-methylhexadecasphing-4-enine => 15-methylhexadecasphing-4-enine + a fatty acid"}
{"X":17469,"RHEA_ID":14253,"DIRECTION":"UN","MASTER_ID":14253,"ec":"3.1.7.2","compounds":"guanosine 3',5'-bis(diphosphate) + H2O = diphosphate + GDP + H(+)"}
{"X":17470,"RHEA_ID":14254,"DIRECTION":"LR","MASTER_ID":14253,"ecocyc":"PPGPPSYN-RXN","metacyc":"PPGPPSYN-RXN","compounds":"guanosine 3',5'-bis(diphosphate) + H2O => diphosphate + GDP + H(+)"}
{"X":17471,"RHEA_ID":14255,"compounds":"diphosphate + GDP + H(+) => guanosine 3',5'-bis(diphosphate) + H2O"}
{"X":17472,"RHEA_ID":24075,"compounds":"(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate <=> 12,13-epoxy-(9Z,11E,15Z)-octadecatrienoate + H2O"}
{"X":17473,"RHEA_ID":14257,"DIRECTION":"UN","MASTER_ID":14257,"ec":"2.4.1.152","compounds":"a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)"}
{"X":17474,"RHEA_ID":14258,"DIRECTION":"LR","MASTER_ID":14257,"metacyc":"GALACTOSIDE-3-FUCOSYLTRANSFERASE-RXN","compounds":"a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose => a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)"}
{"X":17475,"RHEA_ID":14259,"compounds":"a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+) => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose"}
{"X":17476,"RHEA_ID":34720,"compounds":"15-methylhexadecasphing-4-enine 1-phosphate => (2E)-13-methyltetradecenal + phosphoethanolamine"}
{"X":17477,"RHEA_ID":14261,"DIRECTION":"UN","MASTER_ID":14261,"ec":"2.3.1.132","compounds":"D-glucono-1,5-lactone + sinapoyl-CoA = 6-O-sinapoyl-D-glucono-1,5-lactone + CoA"}
{"X":17478,"RHEA_ID":14262,"DIRECTION":"LR","MASTER_ID":14261,"metacyc":"2.3.1.132-RXN","compounds":"D-glucono-1,5-lactone + sinapoyl-CoA => 6-O-sinapoyl-D-glucono-1,5-lactone + CoA"}
{"X":17479,"RHEA_ID":14263,"compounds":"6-O-sinapoyl-D-glucono-1,5-lactone + CoA => D-glucono-1,5-lactone + sinapoyl-CoA"}
{"X":17480,"RHEA_ID":34724,"compounds":"15-methylhexadecasphing-4-enine 1-phosphate + H2O => 15-methylhexadecasphing-4-enine + phosphate"}
{"X":17481,"RHEA_ID":14265,"DIRECTION":"UN","MASTER_ID":14265,"ec":"5.4.3.8","compounds":"(S)-4-amino-5-oxopentanoate = 5-aminolevulinate"}
{"X":17482,"RHEA_ID":14266,"DIRECTION":"LR","MASTER_ID":14265,"ecocyc":"GSAAMINOTRANS-RXN","macie":"M0195","metacyc":"GSAAMINOTRANS-RXN","compounds":"(S)-4-amino-5-oxopentanoate => 5-aminolevulinate"}
{"X":17483,"RHEA_ID":14267,"compounds":"5-aminolevulinate => (S)-4-amino-5-oxopentanoate"}
{"X":17484,"RHEA_ID":14269,"DIRECTION":"UN","MASTER_ID":14269,"ec":"1.6.5.5","compounds":"2 a quinone + H(+) + NADPH = 2 a 1,4-benzosemiquinone + NADP(+)"}
{"X":17485,"RHEA_ID":14270,"compounds":"2 a quinone + H(+) + NADPH => 2 a 1,4-benzosemiquinone + NADP(+)"}
{"X":17486,"RHEA_ID":14271,"compounds":"2 a 1,4-benzosemiquinone + NADP(+) => 2 a quinone + H(+) + NADPH"}
{"X":17487,"RHEA_ID":14273,"DIRECTION":"UN","MASTER_ID":14273,"ec":"1.5.99.6","metacyc":"SPERMIDINE-DEHYDROGENASE-RXN","compounds":"A + H2O + spermidine = 4-aminobutanal + AH2 + propane-1,3-diamine"}
{"X":17488,"RHEA_ID":14274,"compounds":"A + H2O + spermidine => 4-aminobutanal + AH2 + propane-1,3-diamine"}
{"X":17489,"RHEA_ID":14275,"compounds":"4-aminobutanal + AH2 + propane-1,3-diamine => A + H2O + spermidine"}
{"X":17490,"RHEA_ID":14277,"DIRECTION":"UN","MASTER_ID":14277,"ec":"1.2.1.22","compounds":"(S)-lactaldehyde + H2O + NAD(+) = (S)-lactate + 2 H(+) + NADH"}
{"X":17491,"RHEA_ID":14278,"DIRECTION":"LR","MASTER_ID":14277,"ecocyc":"LACTALDDEHYDROG-RXN","metacyc":"LACTALDDEHYDROG-RXN","compounds":"(S)-lactaldehyde + H2O + NAD(+) => (S)-lactate + 2 H(+) + NADH"}
{"X":17492,"RHEA_ID":14279,"compounds":"(S)-lactate + 2 H(+) + NADH => (S)-lactaldehyde + H2O + NAD(+)"}
{"X":17493,"RHEA_ID":14281,"DIRECTION":"UN","MASTER_ID":14281,"ec":"1.8.2.1","compounds":"2 [Fe(III)cytochrome c] + H2O + sulfite = 2 [Fe(II)cytochrome c] + 2 H(+) + sulfate"}
{"X":17494,"RHEA_ID":14282,"DIRECTION":"LR","MASTER_ID":14281,"metacyc":"SULFITE-DEHYDROGENASE-RXN","compounds":"2 [Fe(III)cytochrome c] + H2O + sulfite => 2 [Fe(II)cytochrome c] + 2 H(+) + sulfate"}
{"X":17495,"RHEA_ID":14283,"compounds":"2 [Fe(II)cytochrome c] + 2 H(+) + sulfate => 2 [Fe(III)cytochrome c] + H2O + sulfite"}
{"X":17496,"RHEA_ID":14285,"DIRECTION":"UN","MASTER_ID":14285,"ec":"2.4.1.137","metacyc":"2.4.1.137-RXN","compounds":"sn-glycerol 3-phosphate + UDP-alpha-D-galactose = 2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate + H(+) + UDP"}
{"X":17497,"RHEA_ID":14286,"compounds":"sn-glycerol 3-phosphate + UDP-alpha-D-galactose => 2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate + H(+) + UDP"}
{"X":17498,"RHEA_ID":14287,"compounds":"2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate + H(+) + UDP => sn-glycerol 3-phosphate + UDP-alpha-D-galactose"}
{"X":17499,"RHEA_ID":34748,"compounds":"15-methylhexadecasphinganine + ATP => 15-methylhexadecasphinganine 1-phosphate + ADP + H(+)"}
{"X":17500,"RHEA_ID":14289,"DIRECTION":"UN","MASTER_ID":14289,"ec":"6.2.1.23","compounds":"a dicarboxylate + ATP + CoA = AMP + diphosphate + omega-dicarboxyl-CoA"}
{"X":17501,"RHEA_ID":14290,"DIRECTION":"LR","MASTER_ID":14289,"metacyc":"DICARBOXYLATE--COA-LIGASE-RXN","compounds":"a dicarboxylate + ATP + CoA => AMP + diphosphate + omega-dicarboxyl-CoA"}
{"X":17502,"RHEA_ID":14291,"compounds":"AMP + diphosphate + omega-dicarboxyl-CoA => a dicarboxylate + ATP + CoA"}
{"X":17503,"RHEA_ID":34752,"compounds":"ATP + N-acyl-15-methylhexadecasphing-4-enine => ADP + H(+) + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate"}
{"X":17504,"RHEA_ID":14293,"DIRECTION":"UN","MASTER_ID":14293,"ec":"1.1.1.359","metacyc":"GLUCOSE-1-DEHYDROGENASE-NAD%2b-RXN","compounds":"D-glucose + NAD(+) = D-glucono-1,5-lactone + H(+) + NADH"}
{"X":17505,"RHEA_ID":14293,"DIRECTION":"UN","MASTER_ID":14293,"ec":"1.1.1.47","metacyc":"GLUCOSE-1-DEHYDROGENASE-NAD%2b-RXN","compounds":"D-glucose + NAD(+) = D-glucono-1,5-lactone + H(+) + NADH"}
{"X":17506,"RHEA_ID":14293,"DIRECTION":"UN","MASTER_ID":14293,"ec":"1.1.1.118","metacyc":"GLUCOSE-1-DEHYDROGENASE-NAD%2b-RXN","compounds":"D-glucose + NAD(+) = D-glucono-1,5-lactone + H(+) + NADH"}
{"X":17507,"RHEA_ID":14294,"compounds":"D-glucose + NAD(+) => D-glucono-1,5-lactone + H(+) + NADH"}
{"X":17508,"RHEA_ID":14295,"compounds":"D-glucono-1,5-lactone + H(+) + NADH => D-glucose + NAD(+)"}
{"X":17509,"RHEA_ID":24121,"DIRECTION":"LR","MASTER_ID":24120,"metacyc":"LEUKOTRIENE-E4-20-MONOOXYGENASE-RXN","compounds":"H(+) + leukotriene E4 + NADPH + O2 => 20-hydroxy-leukotriene E4 + H2O + NADP(+)"}
{"X":17510,"RHEA_ID":14297,"DIRECTION":"UN","MASTER_ID":14297,"ec":"3.2.1.46","compounds":"a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-galactose"}
{"X":17511,"RHEA_ID":14298,"DIRECTION":"LR","MASTER_ID":14297,"metacyc":"GALACTOSYLCERAMIDASE-RXN","compounds":"a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O => an N-acylsphing-4-enine + D-galactose"}
{"X":17512,"RHEA_ID":14299,"compounds":"an N-acylsphing-4-enine + D-galactose => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O"}
{"X":17513,"RHEA_ID":14301,"DIRECTION":"UN","MASTER_ID":14301,"ec":"3.1.1.27","compounds":"4-pyridoxolactone + H2O = 4-pyridoxate + H(+)"}
{"X":17514,"RHEA_ID":14302,"DIRECTION":"LR","MASTER_ID":14301,"metacyc":"4-PYRIDOXOLACTONASE-RXN","compounds":"4-pyridoxolactone + H2O => 4-pyridoxate + H(+)"}
{"X":17515,"RHEA_ID":14303,"compounds":"4-pyridoxate + H(+) => 4-pyridoxolactone + H2O"}
{"X":17516,"RHEA_ID":24129,"DIRECTION":"LR","MASTER_ID":24128,"metacyc":"3.6.3.11-RXN","compounds":"ATP + chloride(out) + H2O => ADP + chloride(in) + H(+) + phosphate"}
{"X":17517,"RHEA_ID":14305,"DIRECTION":"UN","MASTER_ID":14305,"ec":"6.1.1.15","compounds":"ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)"}
{"X":17518,"RHEA_ID":14306,"DIRECTION":"LR","MASTER_ID":14305,"ecocyc":"PROLINE--TRNA-LIGASE-RXN","metacyc":"PROLINE--TRNA-LIGASE-RXN","compounds":"ATP + L-proline + tRNA(Pro) => AMP + diphosphate + L-prolyl-tRNA(Pro)"}
{"X":17519,"RHEA_ID":14307,"compounds":"AMP + diphosphate + L-prolyl-tRNA(Pro) => ATP + L-proline + tRNA(Pro)"}
{"X":17520,"RHEA_ID":24133,"compounds":"UDP-alpha-D-galactose => UDP-alpha-D-galactofuranose"}
{"X":17521,"RHEA_ID":14313,"DIRECTION":"UN","MASTER_ID":14313,"ec":"2.1.1.26","compounds":"2-iodophenol + S-adenosyl-L-methionine = 1-iodo-2-methoxybenzene + H(+) + S-adenosyl-L-homocysteine"}
{"X":17522,"RHEA_ID":14314,"DIRECTION":"LR","MASTER_ID":14313,"metacyc":"IODOPHENOL-O-METHYLTRANSFERASE-RXN","compounds":"2-iodophenol + S-adenosyl-L-methionine => 1-iodo-2-methoxybenzene + H(+) + S-adenosyl-L-homocysteine"}
{"X":17523,"RHEA_ID":14315,"compounds":"1-iodo-2-methoxybenzene + H(+) + S-adenosyl-L-homocysteine => 2-iodophenol + S-adenosyl-L-methionine"}
{"X":17524,"RHEA_ID":24137,"compounds":"3'-phosphoadenylyl sulfate + a primary amine => a sulfamate + adenosine 3',5'-bisphosphate + 2 H(+)"}
{"X":17525,"RHEA_ID":14317,"DIRECTION":"UN","MASTER_ID":14317,"ec":"1.1.1.218","compounds":"morphine + NAD(+) = H(+) + morphinone + NADH"}
{"X":17526,"RHEA_ID":14318,"compounds":"morphine + NAD(+) => H(+) + morphinone + NADH"}
{"X":17527,"RHEA_ID":14319,"compounds":"H(+) + morphinone + NADH => morphine + NAD(+)"}
{"X":17528,"RHEA_ID":24141,"DIRECTION":"LR","MASTER_ID":24140,"ecocyc":"RXN-11588","metacyc":"RXN-11588","compounds":"guanosine(2251) in 23S rRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine(2251) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":17529,"RHEA_ID":14321,"DIRECTION":"UN","MASTER_ID":14321,"ec":"1.1.1.218","compounds":"morphine + NADP(+) = H(+) + morphinone + NADPH"}
{"X":17530,"RHEA_ID":14322,"compounds":"morphine + NADP(+) => H(+) + morphinone + NADPH"}
{"X":17531,"RHEA_ID":14323,"compounds":"H(+) + morphinone + NADPH => morphine + NADP(+)"}
{"X":17532,"RHEA_ID":24145,"compounds":"3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA => 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O"}
{"X":17533,"RHEA_ID":14325,"DIRECTION":"UN","MASTER_ID":14325,"ec":"2.4.1.104","compounds":"7,8-dihydroxycoumarin + UDP-alpha-D-glucose = daphnin + H(+) + UDP"}
{"X":17534,"RHEA_ID":14326,"DIRECTION":"LR","MASTER_ID":14325,"metacyc":"2.4.1.104-RXN","compounds":"7,8-dihydroxycoumarin + UDP-alpha-D-glucose => daphnin + H(+) + UDP"}
{"X":17535,"RHEA_ID":14327,"compounds":"daphnin + H(+) + UDP => 7,8-dihydroxycoumarin + UDP-alpha-D-glucose"}
{"X":17536,"RHEA_ID":24149,"compounds":"D-glyceraldehyde 3-phosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (2R)-3-phosphoglycerate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":17537,"RHEA_ID":14329,"DIRECTION":"UN","MASTER_ID":14329,"ec":"2.6.1.52","compounds":"2-oxoglutarate + O-phospho-L-serine = 3-phosphooxypyruvate + L-glutamate"}
{"X":17538,"RHEA_ID":14330,"compounds":"2-oxoglutarate + O-phospho-L-serine => 3-phosphooxypyruvate + L-glutamate"}
{"X":17539,"RHEA_ID":14331,"DIRECTION":"RL","MASTER_ID":14329,"reactome":"R-HSA-977333.2","compounds":"3-phosphooxypyruvate + L-glutamate => 2-oxoglutarate + O-phospho-L-serine"}
{"X":17540,"RHEA_ID":24153,"DIRECTION":"LR","MASTER_ID":24152,"reactome":"R-HSA-174389.2","compounds":"adenosine 5'-phosphosulfate + ATP => 3'-phosphoadenylyl sulfate + ADP + H(+)"}
{"X":17541,"RHEA_ID":14333,"DIRECTION":"UN","MASTER_ID":14333,"ec":"4.6.1.14","compounds":"a 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol = 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol"}
{"X":17542,"RHEA_ID":14334,"compounds":"a 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol => 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol"}
{"X":17543,"RHEA_ID":14335,"compounds":"6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol => a 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol"}
{"X":17544,"RHEA_ID":14337,"DIRECTION":"UN","MASTER_ID":14337,"ec":"2.8.2.7","metacyc":"2.8.2.7-RXN","compounds":"3'-phosphoadenylyl sulfate + UDP-N-acetyl-alpha-D-galactosamine 4-sulfate = adenosine 3',5'-bisphosphate + H(+) + UDP-N-acetyl-alpha-D-galactosamine 4,6-bissulfate"}
{"X":17545,"RHEA_ID":14338,"compounds":"3'-phosphoadenylyl sulfate + UDP-N-acetyl-alpha-D-galactosamine 4-sulfate => adenosine 3',5'-bisphosphate + H(+) + UDP-N-acetyl-alpha-D-galactosamine 4,6-bissulfate"}
{"X":17546,"RHEA_ID":14339,"compounds":"adenosine 3',5'-bisphosphate + H(+) + UDP-N-acetyl-alpha-D-galactosamine 4,6-bissulfate => 3'-phosphoadenylyl sulfate + UDP-N-acetyl-alpha-D-galactosamine 4-sulfate"}
{"X":17547,"RHEA_ID":24161,"DIRECTION":"LR","MASTER_ID":24160,"metacyc":"GALACTOSE-OXIDASE-RXN","compounds":"D-galactose + O2 => D-galacto-hexodialdose + H2O2"}
{"X":17548,"RHEA_ID":14341,"DIRECTION":"UN","MASTER_ID":14341,"ec":"2.2.1.5","compounds":"2-oxoglutarate + glyoxylate + H(+) = 2-hydroxy-3-oxoadipate + CO2"}
{"X":17549,"RHEA_ID":14342,"compounds":"2-oxoglutarate + glyoxylate + H(+) => 2-hydroxy-3-oxoadipate + CO2"}
{"X":17550,"RHEA_ID":14343,"compounds":"2-hydroxy-3-oxoadipate + CO2 => 2-oxoglutarate + glyoxylate + H(+)"}
{"X":17551,"RHEA_ID":24165,"compounds":"[thioredoxin]-disulfide + H2O + L-methionyl-[protein] => [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]"}
{"X":17552,"RHEA_ID":14345,"DIRECTION":"UN","MASTER_ID":14345,"ec":"4.1.1.25","compounds":"H(+) + L-tyrosine = CO2 + tyramine"}
{"X":17553,"RHEA_ID":14346,"DIRECTION":"LR","MASTER_ID":14345,"metacyc":"TYROSINE-DECARBOXYLASE-RXN","compounds":"H(+) + L-tyrosine => CO2 + tyramine"}
{"X":17554,"RHEA_ID":14347,"compounds":"CO2 + tyramine => H(+) + L-tyrosine"}
{"X":17555,"RHEA_ID":24169,"DIRECTION":"LR","MASTER_ID":24168,"metacyc":"2.4.1.135-RXN","compounds":"3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate => 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP"}
{"X":17556,"RHEA_ID":14349,"DIRECTION":"UN","MASTER_ID":14349,"ec":"2.4.1.37","compounds":"an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-alpha-D-galactose = an alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP"}
{"X":17557,"RHEA_ID":14350,"DIRECTION":"LR","MASTER_ID":14349,"metacyc":"2.4.1.37-RXN","compounds":"an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-alpha-D-galactose => an alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP"}
{"X":17558,"RHEA_ID":14351,"compounds":"an alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP => an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-alpha-D-galactose"}
{"X":17559,"RHEA_ID":24173,"compounds":"A + a 3-oxo-5beta-steroid => a 3-oxo-Delta(4)-steroid + AH2"}
{"X":17560,"RHEA_ID":14353,"DIRECTION":"UN","MASTER_ID":14353,"ec":"4.1.1.85","compounds":"3-dehydro-L-gulonate 6-phosphate + H(+) = CO2 + L-xylulose 5-phosphate"}
{"X":17561,"RHEA_ID":14354,"DIRECTION":"LR","MASTER_ID":14353,"ecocyc":"RXN0-705","macie":"M0236","metacyc":"RXN0-705","compounds":"3-dehydro-L-gulonate 6-phosphate + H(+) => CO2 + L-xylulose 5-phosphate"}
{"X":17562,"RHEA_ID":14355,"compounds":"CO2 + L-xylulose 5-phosphate => 3-dehydro-L-gulonate 6-phosphate + H(+)"}
{"X":17563,"RHEA_ID":24177,"DIRECTION":"LR","MASTER_ID":24176,"ecocyc":"RXN-18388","metacyc":"RXN-18388","compounds":"[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":17564,"RHEA_ID":14357,"DIRECTION":"UN","MASTER_ID":14357,"ec":"2.7.1.26","compounds":"ATP + riboflavin = ADP + FMN + H(+)"}
{"X":17565,"RHEA_ID":14358,"DIRECTION":"LR","MASTER_ID":14357,"ecocyc":"RIBOFLAVINKIN-RXN","metacyc":"RIBOFLAVINKIN-RXN","reactome":"R-HSA-196964.2","compounds":"ATP + riboflavin => ADP + FMN + H(+)"}
{"X":17566,"RHEA_ID":14359,"compounds":"ADP + FMN + H(+) => ATP + riboflavin"}
{"X":17567,"RHEA_ID":24181,"compounds":"2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] => CoA + H(+) + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein]"}
{"X":17568,"RHEA_ID":14361,"DIRECTION":"UN","MASTER_ID":14361,"ec":"1.8.3.5","compounds":"H2O + O2 + S-prenyl-L-cysteine = 3-methyl-2-butenal + H2O2 + L-cysteine"}
{"X":17569,"RHEA_ID":14362,"DIRECTION":"LR","MASTER_ID":14361,"metacyc":"1.8.3.5-RXN","compounds":"H2O + O2 + S-prenyl-L-cysteine => 3-methyl-2-butenal + H2O2 + L-cysteine"}
{"X":17570,"RHEA_ID":14363,"compounds":"3-methyl-2-butenal + H2O2 + L-cysteine => H2O + O2 + S-prenyl-L-cysteine"}
{"X":17571,"RHEA_ID":14364,"compounds":"H2O + O2 + S-prenyl-L-cysteine <=> 3-methyl-2-butenal + H2O2 + L-cysteine"}
{"X":17572,"RHEA_ID":14365,"DIRECTION":"UN","MASTER_ID":14365,"ec":"3.5.1.7","metacyc":"UREIDOSUCCINASE-RXN","compounds":"2 H(+) + H2O + N-carbamoyl-L-aspartate = CO2 + L-aspartate + NH4(+)"}
{"X":17573,"RHEA_ID":14366,"compounds":"2 H(+) + H2O + N-carbamoyl-L-aspartate => CO2 + L-aspartate + NH4(+)"}
{"X":17574,"RHEA_ID":14367,"compounds":"CO2 + L-aspartate + NH4(+) => 2 H(+) + H2O + N-carbamoyl-L-aspartate"}
{"X":17575,"RHEA_ID":24189,"compounds":"cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD(+) => 1,2-dihydroxydibenzothiophene + H(+) + NADH"}
{"X":17576,"RHEA_ID":14369,"DIRECTION":"UN","MASTER_ID":14369,"ec":"3.1.3.18","compounds":"2-phosphoglycolate + H2O = glycolate + phosphate"}
{"X":17577,"RHEA_ID":14370,"DIRECTION":"LR","MASTER_ID":14369,"ecocyc":"GPH-RXN","metacyc":"GPH-RXN","compounds":"2-phosphoglycolate + H2O => glycolate + phosphate"}
{"X":17578,"RHEA_ID":14371,"compounds":"glycolate + phosphate => 2-phosphoglycolate + H2O"}
{"X":17579,"RHEA_ID":14373,"compounds":"5beta-cholestane-3alpha,7alpha,12alpha-triol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + H2O + 2 oxidized [adrenodoxin]"}
{"X":17580,"RHEA_ID":14374,"DIRECTION":"LR","MASTER_ID":14373,"metacyc":"CHOLESTANETRIOL-26-MONOOXYGENASE-RXN","compounds":"5beta-cholestane-3alpha,7alpha,12alpha-triol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + H2O + 2 oxidized [adrenodoxin]"}
{"X":17581,"RHEA_ID":14375,"compounds":"(25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + H2O + 2 oxidized [adrenodoxin] => 5beta-cholestane-3alpha,7alpha,12alpha-triol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}
{"X":17582,"RHEA_ID":24196,"DIRECTION":"UN","MASTER_ID":24196,"ec":"1.4.1.26","compounds":"(2R,4S)-2,4-diaminopentanoate + H2O + NAD(+) = (2R)-2-amino-4-oxopentanoate + H(+) + NADH + NH4(+)"}
{"X":17583,"RHEA_ID":14377,"DIRECTION":"UN","MASTER_ID":14377,"ec":"4.1.3.14","metacyc":"3-HYDROXYASPARTATE-ALDOLASE-RXN","compounds":"(3R)-3-hydroxy-L-aspartate = glycine + glyoxylate"}
{"X":17584,"RHEA_ID":14378,"compounds":"(3R)-3-hydroxy-L-aspartate => glycine + glyoxylate"}
{"X":17585,"RHEA_ID":14379,"compounds":"glycine + glyoxylate => (3R)-3-hydroxy-L-aspartate"}
{"X":17586,"RHEA_ID":14381,"DIRECTION":"UN","MASTER_ID":14381,"ec":"1.2.1.54","compounds":"4-guanidinobutanal + H2O + NAD(+) = 4-guanidinobutanoate + 2 H(+) + NADH"}
{"X":17587,"RHEA_ID":14382,"DIRECTION":"LR","MASTER_ID":14381,"metacyc":"1.2.1.54-RXN","compounds":"4-guanidinobutanal + H2O + NAD(+) => 4-guanidinobutanoate + 2 H(+) + NADH"}
{"X":17588,"RHEA_ID":14383,"compounds":"4-guanidinobutanoate + 2 H(+) + NADH => 4-guanidinobutanal + H2O + NAD(+)"}
{"X":17589,"RHEA_ID":14385,"DIRECTION":"UN","MASTER_ID":14385,"ec":"3.6.1.43","compounds":"dolichyl diphosphate + H2O = dolichyl phosphate + H(+) + phosphate"}
{"X":17590,"RHEA_ID":14386,"compounds":"dolichyl diphosphate + H2O => dolichyl phosphate + H(+) + phosphate"}
{"X":17591,"RHEA_ID":14387,"compounds":"dolichyl phosphate + H(+) + phosphate => dolichyl diphosphate + H2O"}
{"X":17592,"RHEA_ID":14389,"DIRECTION":"UN","MASTER_ID":14389,"ec":"2.4.1.149","compounds":"a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP"}
{"X":17593,"RHEA_ID":14390,"DIRECTION":"LR","MASTER_ID":14389,"metacyc":"2.4.1.149-RXN","compounds":"a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine => an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP"}
{"X":17594,"RHEA_ID":14391,"compounds":"an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":17595,"RHEA_ID":24211,"DIRECTION":"BI","MASTER_ID":24208,"metacyc":"1.1.1.292-RXN","compounds":"1,5-anhydro-D-mannitol + NADP(+) <=> 1,5-anhydro-D-fructose + H(+) + NADPH"}
{"X":17596,"RHEA_ID":14393,"DIRECTION":"UN","MASTER_ID":14393,"ec":"2.1.1.301","compounds":"N-terminal L-alanyl-[cypemycin] + 2 S-adenosyl-L-methionine = 3 H(+) + N-terminal N,N-dimethyl-L-alanyl-[cypemycin] + 2 S-adenosyl-L-homocysteine"}
{"X":17597,"RHEA_ID":14394,"compounds":"N-terminal L-alanyl-[cypemycin] + 2 S-adenosyl-L-methionine => 3 H(+) + N-terminal N,N-dimethyl-L-alanyl-[cypemycin] + 2 S-adenosyl-L-homocysteine"}
{"X":17598,"RHEA_ID":14395,"compounds":"3 H(+) + N-terminal N,N-dimethyl-L-alanyl-[cypemycin] + 2 S-adenosyl-L-homocysteine => N-terminal L-alanyl-[cypemycin] + 2 S-adenosyl-L-methionine"}
{"X":17599,"RHEA_ID":14396,"DIRECTION":"BI","MASTER_ID":14393,"metacyc":"RXN-15243","compounds":"N-terminal L-alanyl-[cypemycin] + 2 S-adenosyl-L-methionine <=> 3 H(+) + N-terminal N,N-dimethyl-L-alanyl-[cypemycin] + 2 S-adenosyl-L-homocysteine"}
{"X":17600,"RHEA_ID":14397,"DIRECTION":"UN","MASTER_ID":14397,"ec":"4.1.1.68","compounds":"(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+) = (4Z)-2-oxohept-4-enedioate + CO2"}
{"X":17601,"RHEA_ID":14398,"DIRECTION":"LR","MASTER_ID":14397,"metacyc":"4.1.1.68-RXN","compounds":"(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+) => (4Z)-2-oxohept-4-enedioate + CO2"}
{"X":17602,"RHEA_ID":14399,"compounds":"(4Z)-2-oxohept-4-enedioate + CO2 => (3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+)"}
{"X":17603,"RHEA_ID":34852,"compounds":"(3S)-3-hydroxyadipyl-CoA + NAD(+) => 3-oxoadipyl-CoA + H(+) + NADH"}
{"X":17604,"RHEA_ID":14401,"DIRECTION":"UN","MASTER_ID":14401,"ec":"1.1.1.225","compounds":"chlordecone alcohol + NADP(+) = chlordecone + H(+) + NADPH"}
{"X":17605,"RHEA_ID":14402,"compounds":"chlordecone alcohol + NADP(+) => chlordecone + H(+) + NADPH"}
{"X":17606,"RHEA_ID":14403,"compounds":"chlordecone + H(+) + NADPH => chlordecone alcohol + NADP(+)"}
{"X":17607,"RHEA_ID":34856,"compounds":"2 H2O + iminodiacetonitrile => N-(cyanomethyl)glycine + NH4(+)"}
{"X":17608,"RHEA_ID":14405,"DIRECTION":"UN","MASTER_ID":14405,"ec":"1.1.1.47","compounds":"D-glucose + NADP(+) = D-glucono-1,5-lactone + H(+) + NADPH"}
{"X":17609,"RHEA_ID":14405,"DIRECTION":"UN","MASTER_ID":14405,"ec":"1.1.1.119","compounds":"D-glucose + NADP(+) = D-glucono-1,5-lactone + H(+) + NADPH"}
{"X":17610,"RHEA_ID":14405,"DIRECTION":"UN","MASTER_ID":14405,"ec":"1.1.1.359","compounds":"D-glucose + NADP(+) = D-glucono-1,5-lactone + H(+) + NADPH"}
{"X":17611,"RHEA_ID":14405,"DIRECTION":"UN","MASTER_ID":14405,"ec":"1.1.1.360","compounds":"D-glucose + NADP(+) = D-glucono-1,5-lactone + H(+) + NADPH"}
{"X":17612,"RHEA_ID":14406,"DIRECTION":"LR","MASTER_ID":14405,"metacyc":"GLUCOSE-1-DEHYDROGENASE-NADP%2b-RXN","compounds":"D-glucose + NADP(+) => D-glucono-1,5-lactone + H(+) + NADPH"}
{"X":17613,"RHEA_ID":14407,"compounds":"D-glucono-1,5-lactone + H(+) + NADPH => D-glucose + NADP(+)"}
{"X":17614,"RHEA_ID":24230,"compounds":"4-methylcatechol + CO2 + NADH => (1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NAD(+)"}
{"X":17615,"RHEA_ID":14409,"DIRECTION":"UN","MASTER_ID":14409,"ec":"1.13.11.19","compounds":"cysteamine + O2 = H(+) + hypotaurine"}
{"X":17616,"RHEA_ID":14410,"DIRECTION":"LR","MASTER_ID":14409,"metacyc":"CYSTEAMINE-DIOXYGENASE-RXN","reactome":"R-HSA-6814153.1","compounds":"cysteamine + O2 => H(+) + hypotaurine"}
{"X":17617,"RHEA_ID":14411,"compounds":"H(+) + hypotaurine => cysteamine + O2"}
{"X":17618,"RHEA_ID":14413,"DIRECTION":"UN","MASTER_ID":14413,"ec":"1.13.11.39","compounds":"biphenyl-2,3-diol + O2 = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+)"}
{"X":17619,"RHEA_ID":14414,"DIRECTION":"LR","MASTER_ID":14413,"metacyc":"BIPHENYL-23-DIOL-12-DIOXYGENASE-RXN","compounds":"biphenyl-2,3-diol + O2 => 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+)"}
{"X":17620,"RHEA_ID":14415,"compounds":"2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+) => biphenyl-2,3-diol + O2"}
{"X":17621,"RHEA_ID":24238,"DIRECTION":"RL","MASTER_ID":24236,"ecocyc":"1.7.2.3-RXN","metacyc":"1.7.2.3-RXN","compounds":"2 [Fe(II)cytochrome c] + 3 H(+) + trimethylamine N-oxide => 2 [Fe(III)cytochrome c] + H2O + trimethylamine"}
{"X":17622,"RHEA_ID":14417,"DIRECTION":"UN","MASTER_ID":14417,"ec":"2.3.1.32","compounds":"acetyl phosphate + L-lysine = H(+) + N(6)-acetyl-L-lysine + phosphate"}
{"X":17623,"RHEA_ID":14418,"compounds":"acetyl phosphate + L-lysine => H(+) + N(6)-acetyl-L-lysine + phosphate"}
{"X":17624,"RHEA_ID":14419,"compounds":"H(+) + N(6)-acetyl-L-lysine + phosphate => acetyl phosphate + L-lysine"}
{"X":17625,"RHEA_ID":24242,"compounds":"adenosine 5'-phosphosulfate + AH2 => A + AMP + 2 H(+) + sulfite"}
{"X":17626,"RHEA_ID":14421,"DIRECTION":"UN","MASTER_ID":14421,"ec":"3.5.1.72","metacyc":"3.5.1.72-RXN","compounds":"H2O + N(2)-benzoyl-D-arginine-4-nitroanilide = 4-nitroaniline + H(+) + N(2)-benzoyl-D-arginine"}
{"X":17627,"RHEA_ID":14422,"compounds":"H2O + N(2)-benzoyl-D-arginine-4-nitroanilide => 4-nitroaniline + H(+) + N(2)-benzoyl-D-arginine"}
{"X":17628,"RHEA_ID":14423,"compounds":"4-nitroaniline + H(+) + N(2)-benzoyl-D-arginine => H2O + N(2)-benzoyl-D-arginine-4-nitroanilide"}
{"X":17629,"RHEA_ID":24246,"DIRECTION":"RL","MASTER_ID":24244,"metacyc":"TROPINONE-REDUCTASE-RXN","compounds":"H(+) + NADPH + tropinone => NADP(+) + pseudotropine"}
{"X":17630,"RHEA_ID":14425,"DIRECTION":"UN","MASTER_ID":14425,"ec":"2.7.1.68","compounds":"1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)"}
{"X":17631,"RHEA_ID":14426,"DIRECTION":"LR","MASTER_ID":14425,"metacyc":"2.7.1.68-RXN","compounds":"1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)"}
{"X":17632,"RHEA_ID":14427,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+) => 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP"}
{"X":17633,"RHEA_ID":24249,"DIRECTION":"LR","MASTER_ID":24248,"metacyc":"ALANINE--GLYOXYLATE-AMINOTRANSFERASE-RXN","reactome":"R-HSA-389684.3","compounds":"glyoxylate + L-alanine => glycine + pyruvate"}
{"X":17634,"RHEA_ID":14429,"DIRECTION":"UN","MASTER_ID":14429,"ec":"7.4.2.5","compounds":"a [peptide](in) + ATP + H2O = a [peptide](out) + ADP + H(+) + phosphate"}
{"X":17635,"RHEA_ID":14430,"DIRECTION":"LR","MASTER_ID":14429,"metacyc":"3.6.3.23-RXN","compounds":"a [peptide](in) + ATP + H2O => a [peptide](out) + ADP + H(+) + phosphate"}
{"X":17636,"RHEA_ID":14430,"DIRECTION":"LR","MASTER_ID":14429,"metacyc":"3.6.3.43-RXN","compounds":"a [peptide](in) + ATP + H2O => a [peptide](out) + ADP + H(+) + phosphate"}
{"X":17637,"RHEA_ID":14431,"compounds":"a [peptide](out) + ADP + H(+) + phosphate => a [peptide](in) + ATP + H2O"}
{"X":17638,"RHEA_ID":14432,"compounds":"a [peptide](in) + ATP + H2O <=> a [peptide](out) + ADP + H(+) + phosphate"}
{"X":17639,"RHEA_ID":14433,"DIRECTION":"UN","MASTER_ID":14433,"ec":"2.7.7.72","compounds":"a tRNA precursor + ATP + 2 CTP = a tRNA with a 3' CCA end + 3 diphosphate"}
{"X":17640,"RHEA_ID":14434,"DIRECTION":"LR","MASTER_ID":14433,"ecocyc":"TRNA-CYTIDYLYLTRANSFERASE-RXN","metacyc":"TRNA-CYTIDYLYLTRANSFERASE-RXN","compounds":"a tRNA precursor + ATP + 2 CTP => a tRNA with a 3' CCA end + 3 diphosphate"}
{"X":17641,"RHEA_ID":14435,"compounds":"a tRNA with a 3' CCA end + 3 diphosphate => a tRNA precursor + ATP + 2 CTP"}
{"X":17642,"RHEA_ID":14437,"DIRECTION":"UN","MASTER_ID":14437,"ec":"1.4.3.14","compounds":"H2O + L-lysine + O2 = 6-amino-2-oxohexanoate + H2O2 + NH4(+)"}
{"X":17643,"RHEA_ID":14438,"DIRECTION":"LR","MASTER_ID":14437,"metacyc":"L-LYSINE-OXIDASE-RXN","compounds":"H2O + L-lysine + O2 => 6-amino-2-oxohexanoate + H2O2 + NH4(+)"}
{"X":17644,"RHEA_ID":14439,"compounds":"6-amino-2-oxohexanoate + H2O2 + NH4(+) => H2O + L-lysine + O2"}
{"X":17645,"RHEA_ID":24262,"compounds":"2-oxopent-4-enoate + CO2 => (3E)-2-oxohex-3-enedioate + H(+)"}
{"X":17646,"RHEA_ID":14441,"DIRECTION":"UN","MASTER_ID":14441,"ec":"2.3.1.60","compounds":"acetyl-CoA + gentamicin C = CoA + H(+) + N(3)-acetylgentamycin C"}
{"X":17647,"RHEA_ID":14442,"compounds":"acetyl-CoA + gentamicin C => CoA + H(+) + N(3)-acetylgentamycin C"}
{"X":17648,"RHEA_ID":14443,"compounds":"CoA + H(+) + N(3)-acetylgentamycin C => acetyl-CoA + gentamicin C"}
{"X":17649,"RHEA_ID":24266,"compounds":"D-glyceraldehyde 3-phosphate + dihydroxyacetone => D-xylulose 5-phosphate + formaldehyde"}
{"X":17650,"RHEA_ID":14445,"DIRECTION":"UN","MASTER_ID":14445,"ec":"3.1.4.4","compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)"}
{"X":17651,"RHEA_ID":14446,"DIRECTION":"LR","MASTER_ID":14445,"metacyc":"PHOSCHOL-RXN","compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O => a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)"}
{"X":17652,"RHEA_ID":14447,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+) => a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O"}
{"X":17653,"RHEA_ID":14449,"DIRECTION":"UN","MASTER_ID":14449,"ec":"1.3.1.75","compounds":"chlorophyllide a + NADP(+) = 3,8-divinyl chlorophyllide a + H(+) + NADPH"}
{"X":17654,"RHEA_ID":14450,"compounds":"chlorophyllide a + NADP(+) => 3,8-divinyl chlorophyllide a + H(+) + NADPH"}
{"X":17655,"RHEA_ID":14451,"DIRECTION":"RL","MASTER_ID":14449,"metacyc":"RXN-5286","compounds":"3,8-divinyl chlorophyllide a + H(+) + NADPH => chlorophyllide a + NADP(+)"}
{"X":17656,"RHEA_ID":24274,"compounds":"H2O + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADP(+) => H(+) + Mg-protoporphyrin IX 13-monomethyl ester + NADPH + O2"}
{"X":17657,"RHEA_ID":14453,"compounds":"4-(phosphooxy)-L-threonine + NAD(+) = (2S)-2-amino-3-oxo-4-(phosphooxy)butanoate + H(+) + NADH"}
{"X":17658,"RHEA_ID":14454,"DIRECTION":"LR","MASTER_ID":14453,"ecocyc":"1.1.1.262-RXN","metacyc":"1.1.1.262-RXN","compounds":"4-(phosphooxy)-L-threonine + NAD(+) => (2S)-2-amino-3-oxo-4-(phosphooxy)butanoate + H(+) + NADH"}
{"X":17659,"RHEA_ID":14455,"compounds":"(2S)-2-amino-3-oxo-4-(phosphooxy)butanoate + H(+) + NADH => 4-(phosphooxy)-L-threonine + NAD(+)"}
{"X":17660,"RHEA_ID":24278,"compounds":"acetyl phosphate + phosphate => acetate + diphosphate"}
{"X":17661,"RHEA_ID":14457,"DIRECTION":"UN","MASTER_ID":14457,"ec":"2.3.3.12","metacyc":"3-PROPYLMALATE-SYNTHASE-RXN","compounds":"glyoxylate + H2O + pentanoyl-CoA = 3-propylmalate + CoA + H(+)"}
{"X":17662,"RHEA_ID":14458,"compounds":"glyoxylate + H2O + pentanoyl-CoA => 3-propylmalate + CoA + H(+)"}
{"X":17663,"RHEA_ID":14459,"compounds":"3-propylmalate + CoA + H(+) => glyoxylate + H2O + pentanoyl-CoA"}
{"X":17664,"RHEA_ID":24282,"compounds":"2 H(+) + 2 S-adenosyl-L-homocysteine + syringetin => myricetin + 2 S-adenosyl-L-methionine"}
{"X":17665,"RHEA_ID":14461,"DIRECTION":"UN","MASTER_ID":14461,"ec":"2.4.1.193","compounds":"(25S)-5beta-spirostan-3beta-ol + UDP-alpha-D-glucose = (25S)-5beta-spirostan-3beta-yl beta-D-glucoside + H(+) + UDP"}
{"X":17666,"RHEA_ID":14462,"DIRECTION":"LR","MASTER_ID":14461,"metacyc":"2.4.1.193-RXN","compounds":"(25S)-5beta-spirostan-3beta-ol + UDP-alpha-D-glucose => (25S)-5beta-spirostan-3beta-yl beta-D-glucoside + H(+) + UDP"}
{"X":17667,"RHEA_ID":14463,"compounds":"(25S)-5beta-spirostan-3beta-yl beta-D-glucoside + H(+) + UDP => (25S)-5beta-spirostan-3beta-ol + UDP-alpha-D-glucose"}
{"X":17668,"RHEA_ID":24286,"compounds":"4-phospho-L-aspartate + H(+) + NADPH => L-aspartate 4-semialdehyde + NADP(+) + phosphate"}
{"X":17669,"RHEA_ID":14465,"DIRECTION":"UN","MASTER_ID":14465,"ec":"3.1.3.15","compounds":"H2O + L-histidinol phosphate = L-histidinol + phosphate"}
{"X":17670,"RHEA_ID":14466,"DIRECTION":"LR","MASTER_ID":14465,"ecocyc":"HISTIDPHOS-RXN","metacyc":"HISTIDPHOS-RXN","compounds":"H2O + L-histidinol phosphate => L-histidinol + phosphate"}
{"X":17671,"RHEA_ID":14467,"compounds":"L-histidinol + phosphate => H2O + L-histidinol phosphate"}
{"X":17672,"RHEA_ID":24290,"compounds":"(6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine => 5-formimidoyltetrahydrofolate + glycine"}
{"X":17673,"RHEA_ID":14469,"DIRECTION":"UN","MASTER_ID":14469,"ec":"1.2.1.32","compounds":"2-aminomuconate 6-semialdehyde + H2O + NAD(+) = (2Z,4E)-2-aminomuconate + 2 H(+) + NADH"}
{"X":17674,"RHEA_ID":14470,"DIRECTION":"LR","MASTER_ID":14469,"metacyc":"1.2.1.32-RXN","reactome":"R-HSA-71239.2","compounds":"2-aminomuconate 6-semialdehyde + H2O + NAD(+) => (2Z,4E)-2-aminomuconate + 2 H(+) + NADH"}
{"X":17675,"RHEA_ID":14471,"compounds":"(2Z,4E)-2-aminomuconate + 2 H(+) + NADH => 2-aminomuconate 6-semialdehyde + H2O + NAD(+)"}
{"X":17676,"RHEA_ID":24294,"compounds":"CoA + H(+) + N-acetyl-L-glutamate => acetyl-CoA + L-glutamate"}
{"X":17677,"RHEA_ID":14473,"DIRECTION":"UN","MASTER_ID":14473,"ec":"1.3.1.93","compounds":"a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) = a very-long-chain (2E)-enoyl-CoA + H(+) + NADPH"}
{"X":17678,"RHEA_ID":14474,"compounds":"a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) => a very-long-chain (2E)-enoyl-CoA + H(+) + NADPH"}
{"X":17679,"RHEA_ID":14475,"DIRECTION":"RL","MASTER_ID":14473,"metacyc":"RXN-7711","compounds":"a very-long-chain (2E)-enoyl-CoA + H(+) + NADPH => a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+)"}
{"X":17680,"RHEA_ID":14477,"DIRECTION":"UN","MASTER_ID":14477,"ec":"1.3.8.7","compounds":"a medium-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a medium-chain trans-(2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":17681,"RHEA_ID":14478,"compounds":"a medium-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => a medium-chain trans-(2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":17682,"RHEA_ID":14479,"compounds":"a medium-chain trans-(2E)-enoyl-CoA + reduced [electron-transfer flavoprotein] => a medium-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":17683,"RHEA_ID":14481,"DIRECTION":"UN","MASTER_ID":14481,"ec":"3.1.3.87","compounds":"2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate"}
{"X":17684,"RHEA_ID":14482,"DIRECTION":"LR","MASTER_ID":14481,"metacyc":"R83-RXN","compounds":"2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate + H2O => 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate"}
{"X":17685,"RHEA_ID":14483,"compounds":"1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate => 2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate + H2O"}
{"X":17686,"RHEA_ID":24306,"compounds":"(R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2 => glycine + H(+) + N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein]"}
{"X":17687,"RHEA_ID":14485,"DIRECTION":"UN","MASTER_ID":14485,"ec":"4.2.3.172","compounds":"(2E,6E)-farnesyl diphosphate + H2O = 10-epi-juneol + diphosphate"}
{"X":17688,"RHEA_ID":14486,"DIRECTION":"LR","MASTER_ID":14485,"metacyc":"RXN-18826","compounds":"(2E,6E)-farnesyl diphosphate + H2O => 10-epi-juneol + diphosphate"}
{"X":17689,"RHEA_ID":14487,"compounds":"10-epi-juneol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}
{"X":17690,"RHEA_ID":24310,"compounds":"7alpha,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 25-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":17691,"RHEA_ID":14489,"DIRECTION":"UN","MASTER_ID":14489,"ec":"3.1.4.37","compounds":"a nucleoside 2',3'-cyclic phosphate + H2O = a nucleoside 2'-phosphate + H(+)"}
{"X":17692,"RHEA_ID":14490,"DIRECTION":"LR","MASTER_ID":14489,"metacyc":"3.1.4.37-RXN","compounds":"a nucleoside 2',3'-cyclic phosphate + H2O => a nucleoside 2'-phosphate + H(+)"}
{"X":17693,"RHEA_ID":14491,"compounds":"a nucleoside 2'-phosphate + H(+) => a nucleoside 2',3'-cyclic phosphate + H2O"}
{"X":17694,"RHEA_ID":14493,"DIRECTION":"UN","MASTER_ID":14493,"ec":"3.2.2.24","compounds":"H2O + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] = ADP-D-ribose + L-arginyl-[dinitrogen reductase]"}
{"X":17695,"RHEA_ID":14494,"compounds":"H2O + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] => ADP-D-ribose + L-arginyl-[dinitrogen reductase]"}
{"X":17696,"RHEA_ID":14495,"compounds":"ADP-D-ribose + L-arginyl-[dinitrogen reductase] => H2O + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase]"}
{"X":17697,"RHEA_ID":14497,"DIRECTION":"UN","MASTER_ID":14497,"ec":"1.1.99.9","compounds":"A + pyridoxine = AH2 + isopyridoxal"}
{"X":17698,"RHEA_ID":14498,"DIRECTION":"LR","MASTER_ID":14497,"metacyc":"PYRIDOXINE-5-DEHYDROGENASE-RXN","compounds":"A + pyridoxine => AH2 + isopyridoxal"}
{"X":17699,"RHEA_ID":14499,"compounds":"AH2 + isopyridoxal => A + pyridoxine"}
{"X":17700,"RHEA_ID":24322,"compounds":"an L-N-hydroxypolyhomomethionine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an L-polyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":17701,"RHEA_ID":14501,"DIRECTION":"UN","MASTER_ID":14501,"ec":"4.4.1.2","compounds":"H2O + L-homocysteine = 2-oxobutanoate + H(+) + hydrogen sulfide + NH4(+)"}
{"X":17702,"RHEA_ID":14502,"DIRECTION":"LR","MASTER_ID":14501,"metacyc":"HOMOCYSTEINE-DESULFHYDRASE-RXN","compounds":"H2O + L-homocysteine => 2-oxobutanoate + H(+) + hydrogen sulfide + NH4(+)"}
{"X":17703,"RHEA_ID":14503,"compounds":"2-oxobutanoate + H(+) + hydrogen sulfide + NH4(+) => H2O + L-homocysteine"}
{"X":17704,"RHEA_ID":24326,"compounds":"1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + H2O + NADP(+) => 6-oxocineole + H(+) + NADPH + O2"}
{"X":17705,"RHEA_ID":14505,"DIRECTION":"UN","MASTER_ID":14505,"ec":"2.8.1.3","compounds":"2 glutathione + thiosulfate = glutathione disulfide + 2 H(+) + hydrogen sulfide + sulfite"}
{"X":17706,"RHEA_ID":14506,"DIRECTION":"LR","MASTER_ID":14505,"reactome":"R-HSA-1655879.3","compounds":"2 glutathione + thiosulfate => glutathione disulfide + 2 H(+) + hydrogen sulfide + sulfite"}
{"X":17707,"RHEA_ID":14507,"compounds":"glutathione disulfide + 2 H(+) + hydrogen sulfide + sulfite => 2 glutathione + thiosulfate"}
{"X":17708,"RHEA_ID":24330,"compounds":"10-formyldihydrofolate + ADP + phosphate => 7,8-dihydrofolate + ATP + formate"}
{"X":17709,"RHEA_ID":14509,"DIRECTION":"UN","MASTER_ID":14509,"ec":"1.14.11.25","compounds":"2-oxoglutarate + mugineate + O2 = 3-epihydroxymugineate + CO2 + H(+) + succinate"}
{"X":17710,"RHEA_ID":14510,"DIRECTION":"LR","MASTER_ID":14509,"metacyc":"RXN-7982","compounds":"2-oxoglutarate + mugineate + O2 => 3-epihydroxymugineate + CO2 + H(+) + succinate"}
{"X":17711,"RHEA_ID":14511,"compounds":"3-epihydroxymugineate + CO2 + H(+) + succinate => 2-oxoglutarate + mugineate + O2"}
{"X":17712,"RHEA_ID":24334,"compounds":"H2O + monacolin L carboxylate => 3alpha-hydroxy-3,5-dihydromonacolin L carboxylate"}
{"X":17713,"RHEA_ID":14513,"DIRECTION":"UN","MASTER_ID":14513,"ec":"6.3.5.6","compounds":"ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate"}
{"X":17714,"RHEA_ID":14514,"DIRECTION":"LR","MASTER_ID":14513,"metacyc":"6.3.5.6-RXN","compounds":"ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine => ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate"}
{"X":17715,"RHEA_ID":14515,"compounds":"ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate => ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine"}
{"X":17716,"RHEA_ID":24338,"compounds":"AMP + an acyl-CoA + diphosphate => a carboxylate + ATP + CoA"}
{"X":17717,"RHEA_ID":14517,"DIRECTION":"UN","MASTER_ID":14517,"ec":"4.2.1.101","compounds":"3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA = feruloyl-CoA + H2O"}
{"X":17718,"RHEA_ID":14518,"compounds":"3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA => feruloyl-CoA + H2O"}
{"X":17719,"RHEA_ID":14519,"DIRECTION":"RL","MASTER_ID":14517,"metacyc":"4.2.1.101-RXN","compounds":"feruloyl-CoA + H2O => 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA"}
{"X":17720,"RHEA_ID":24342,"compounds":"(R)-acetoin + H(+) + NADH => (R,R)-butane-2,3-diol + NAD(+)"}
{"X":17721,"RHEA_ID":14521,"DIRECTION":"UN","MASTER_ID":14521,"ec":"1.1.1.183","compounds":"geraniol + NADP(+) = geranial + H(+) + NADPH"}
{"X":17722,"RHEA_ID":14522,"DIRECTION":"LR","MASTER_ID":14521,"metacyc":"GERANIOL-DEHYDROGENASE-RXN","compounds":"geraniol + NADP(+) => geranial + H(+) + NADPH"}
{"X":17723,"RHEA_ID":14523,"compounds":"geranial + H(+) + NADPH => geraniol + NADP(+)"}
{"X":17724,"RHEA_ID":24354,"compounds":"ethyl 3-oxohexanoate + H(+) + NADPH => ethyl (R)-3-hydroxyhexanoate + NADP(+)"}
{"X":17725,"RHEA_ID":14525,"DIRECTION":"UN","MASTER_ID":14525,"ec":"1.21.99.1","compounds":"A + beta-cyclopiazonate = AH2 + alpha-cyclopiazonate"}
{"X":17726,"RHEA_ID":14526,"DIRECTION":"LR","MASTER_ID":14525,"metacyc":"BETA-CYCLOPIAZONATE-DEHYDROGENASE-RXN","compounds":"A + beta-cyclopiazonate => AH2 + alpha-cyclopiazonate"}
{"X":17727,"RHEA_ID":14527,"compounds":"AH2 + alpha-cyclopiazonate => A + beta-cyclopiazonate"}
{"X":17728,"RHEA_ID":24358,"compounds":"a 2-acyl-sn-glycero-3-phosphocholine => a 1-acyl-sn-glycero-3-phosphocholine"}
{"X":17729,"RHEA_ID":14529,"DIRECTION":"UN","MASTER_ID":14529,"ec":"2.7.7.35","compounds":"ADP + D-ribose 5-phosphate + H(+) = ADP-D-ribose + phosphate"}
{"X":17730,"RHEA_ID":14530,"compounds":"ADP + D-ribose 5-phosphate + H(+) => ADP-D-ribose + phosphate"}
{"X":17731,"RHEA_ID":14531,"DIRECTION":"RL","MASTER_ID":14529,"metacyc":"2.7.7.35-RXN","compounds":"ADP-D-ribose + phosphate => ADP + D-ribose 5-phosphate + H(+)"}
{"X":17732,"RHEA_ID":24362,"compounds":"Fe(2+) + sirohydrochlorin => 2 H(+) + siroheme"}
{"X":17733,"RHEA_ID":14533,"DIRECTION":"UN","MASTER_ID":14533,"ec":"3.5.2.10","compounds":"creatinine + H2O = creatine"}
{"X":17734,"RHEA_ID":14534,"compounds":"creatinine + H2O => creatine"}
{"X":17735,"RHEA_ID":14535,"compounds":"creatine => creatinine + H2O"}
{"X":17736,"RHEA_ID":24366,"compounds":"2''-O-(2-hydroxyisobutanoyl)-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + NAD(+)"}
{"X":17737,"RHEA_ID":14537,"DIRECTION":"UN","MASTER_ID":14537,"ec":"3.5.4.20","metacyc":"PYRITHIAMIN-DEAMINASE-RXN","compounds":"1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + H(+) + H2O = 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + NH4(+)"}
{"X":17738,"RHEA_ID":14538,"compounds":"1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + H(+) + H2O => 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + NH4(+)"}
{"X":17739,"RHEA_ID":14539,"compounds":"1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + NH4(+) => 1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + H(+) + H2O"}
{"X":17740,"RHEA_ID":24370,"compounds":"L-proline + NH4(+) => L-ornithine"}
{"X":17741,"RHEA_ID":14541,"DIRECTION":"UN","MASTER_ID":14541,"ec":"3.1.2.27","compounds":"choloyl-CoA + H2O = cholate + CoA + H(+)"}
{"X":17742,"RHEA_ID":14542,"DIRECTION":"LR","MASTER_ID":14541,"reactome":"R-HSA-193385.1","compounds":"choloyl-CoA + H2O => cholate + CoA + H(+)"}
{"X":17743,"RHEA_ID":14543,"compounds":"cholate + CoA + H(+) => choloyl-CoA + H2O"}
{"X":17744,"RHEA_ID":14545,"DIRECTION":"UN","MASTER_ID":14545,"ec":"3.5.1.19","compounds":"H2O + nicotinamide = NH4(+) + nicotinate"}
{"X":17745,"RHEA_ID":14546,"DIRECTION":"LR","MASTER_ID":14545,"ecocyc":"NICOTINAMID-RXN","metacyc":"NICOTINAMID-RXN","compounds":"H2O + nicotinamide => NH4(+) + nicotinate"}
{"X":17746,"RHEA_ID":14547,"compounds":"NH4(+) + nicotinate => H2O + nicotinamide"}
{"X":17747,"RHEA_ID":24378,"compounds":"AMP + diphosphate + H(+) + holo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] => apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin"}
{"X":17748,"RHEA_ID":14549,"DIRECTION":"UN","MASTER_ID":14549,"ec":"3.7.1.9","compounds":"(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O = 2-oxopent-4-enoate + formate + H(+)"}
{"X":17749,"RHEA_ID":14550,"DIRECTION":"LR","MASTER_ID":14549,"metacyc":"3.7.1.9-RXN","compounds":"(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O => 2-oxopent-4-enoate + formate + H(+)"}
{"X":17750,"RHEA_ID":14551,"compounds":"2-oxopent-4-enoate + formate + H(+) => (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O"}
{"X":17751,"RHEA_ID":24382,"compounds":"(6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet) => (6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet)"}
{"X":17752,"RHEA_ID":14553,"DIRECTION":"UN","MASTER_ID":14553,"ec":"2.6.1.74","compounds":"(7R)-7-(5-carboxy-5-oxopentanamido)deacetylcephalosporanate + D-glutamate = 2-oxoglutarate + cephalosporin C"}
{"X":17753,"RHEA_ID":14554,"compounds":"(7R)-7-(5-carboxy-5-oxopentanamido)deacetylcephalosporanate + D-glutamate => 2-oxoglutarate + cephalosporin C"}
{"X":17754,"RHEA_ID":14555,"compounds":"2-oxoglutarate + cephalosporin C => (7R)-7-(5-carboxy-5-oxopentanamido)deacetylcephalosporanate + D-glutamate"}
{"X":17755,"RHEA_ID":24386,"compounds":"AMP + diphosphate + H(+) + L-glutamate + NAD(+) => ATP + deamido-NAD(+) + H2O + L-glutamine"}
{"X":17756,"RHEA_ID":14557,"DIRECTION":"UN","MASTER_ID":14557,"ec":"3.2.1.125","compounds":"H2O + raucaffricine = D-glucose + vomilenine"}
{"X":17757,"RHEA_ID":14558,"DIRECTION":"LR","MASTER_ID":14557,"metacyc":"RAUCAFFRICINE-BETA-GLUCOSIDASE-RXN","compounds":"H2O + raucaffricine => D-glucose + vomilenine"}
{"X":17758,"RHEA_ID":14559,"compounds":"D-glucose + vomilenine => H2O + raucaffricine"}
{"X":17759,"RHEA_ID":24389,"compounds":"phosphate + uridine => alpha-D-ribose 1-phosphate + uracil"}
{"X":17760,"RHEA_ID":14561,"DIRECTION":"UN","MASTER_ID":14561,"ec":"2.3.1.145","compounds":"(E,E)-piperoyl-CoA + piperidine = CoA + H(+) + N-[(E,E)-piperoyl]piperidine"}
{"X":17761,"RHEA_ID":14562,"DIRECTION":"LR","MASTER_ID":14561,"metacyc":"PIPERIDINE-N-PIPEROYLTRANSFERASE-RXN","compounds":"(E,E)-piperoyl-CoA + piperidine => CoA + H(+) + N-[(E,E)-piperoyl]piperidine"}
{"X":17762,"RHEA_ID":14563,"compounds":"CoA + H(+) + N-[(E,E)-piperoyl]piperidine => (E,E)-piperoyl-CoA + piperidine"}
{"X":17763,"RHEA_ID":24393,"DIRECTION":"LR","MASTER_ID":24392,"metacyc":"2.4.2.27-RXN","compounds":"dTDP-L-dihydrostreptose + streptidine 6-phosphate => dTDP + H(+) + O-(1->4)-alpha-L-dihydrostreptosyl-streptidine 6-phosphate"}
{"X":17764,"RHEA_ID":14565,"DIRECTION":"UN","MASTER_ID":14565,"ec":"2.3.1.179","compounds":"(11Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(13Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]"}
{"X":17765,"RHEA_ID":14566,"DIRECTION":"LR","MASTER_ID":14565,"ecocyc":"2.3.1.179-RXN","metacyc":"2.3.1.179-RXN","compounds":"(11Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxo-(13Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]"}
{"X":17766,"RHEA_ID":14567,"compounds":"3-oxo-(13Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP] => (11Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP]"}
{"X":17767,"RHEA_ID":14568,"compounds":"(11Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxo-(13Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]"}
{"X":17768,"RHEA_ID":14569,"DIRECTION":"UN","MASTER_ID":14569,"ec":"4.2.1.28","compounds":"propane-1,2-diol = H2O + propanal"}
{"X":17769,"RHEA_ID":14570,"DIRECTION":"LR","MASTER_ID":14569,"metacyc":"PROPANEDIOL-DEHYDRATASE-RXN","compounds":"propane-1,2-diol => H2O + propanal"}
{"X":17770,"RHEA_ID":14571,"compounds":"H2O + propanal => propane-1,2-diol"}
{"X":17771,"RHEA_ID":14573,"DIRECTION":"UN","MASTER_ID":14573,"ec":"4.2.1.40","compounds":"D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H2O"}
{"X":17772,"RHEA_ID":14574,"DIRECTION":"LR","MASTER_ID":14573,"ecocyc":"GLUCARDEHYDRA-RXN","metacyc":"GLUCARDEHYDRA-RXN","compounds":"D-glucarate => 5-dehydro-4-deoxy-D-glucarate + H2O"}
{"X":17773,"RHEA_ID":14575,"compounds":"5-dehydro-4-deoxy-D-glucarate + H2O => D-glucarate"}
{"X":17774,"RHEA_ID":24404,"DIRECTION":"UN","MASTER_ID":24404,"ec":"4.1.3.4","compounds":"(3S)-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA"}
{"X":17775,"RHEA_ID":14577,"compounds":"(R)-carnitine = crotonobetaine + H2O"}
{"X":17776,"RHEA_ID":14578,"compounds":"(R)-carnitine => crotonobetaine + H2O"}
{"X":17777,"RHEA_ID":14579,"compounds":"crotonobetaine + H2O => (R)-carnitine"}
{"X":17778,"RHEA_ID":14581,"DIRECTION":"UN","MASTER_ID":14581,"ec":"1.6.5.4","compounds":"H(+) + 2 monodehydro-L-ascorbate radical + NADH = 2 L-ascorbate + NAD(+)"}
{"X":17779,"RHEA_ID":14582,"DIRECTION":"LR","MASTER_ID":14581,"metacyc":"1.6.5.4-RXN","compounds":"H(+) + 2 monodehydro-L-ascorbate radical + NADH => 2 L-ascorbate + NAD(+)"}
{"X":17780,"RHEA_ID":14583,"compounds":"2 L-ascorbate + NAD(+) => H(+) + 2 monodehydro-L-ascorbate radical + NADH"}
{"X":17781,"RHEA_ID":24410,"compounds":"inosine + NH4(+) => adenosine + H(+) + H2O"}
{"X":17782,"RHEA_ID":14589,"compounds":"luteolin + S-adenosyl-L-methionine = 4',5,7-trihydroxy-3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine"}
{"X":17783,"RHEA_ID":14590,"DIRECTION":"LR","MASTER_ID":14589,"metacyc":"LUTEOLIN-O-METHYLTRANSFERASE-RXN","compounds":"luteolin + S-adenosyl-L-methionine => 4',5,7-trihydroxy-3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine"}
{"X":17784,"RHEA_ID":14591,"compounds":"4',5,7-trihydroxy-3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine => luteolin + S-adenosyl-L-methionine"}
{"X":17785,"RHEA_ID":24414,"compounds":"4-formylbenzenesulfonate + H(+) + NADH => 4-(hydroxymethyl)benzenesulfonate + NAD(+)"}
{"X":17786,"RHEA_ID":14597,"DIRECTION":"UN","MASTER_ID":14597,"ec":"2.7.8.24","compounds":"a CDP-1,2-diacyl-sn-glycerol + choline = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)"}
{"X":17787,"RHEA_ID":14598,"DIRECTION":"LR","MASTER_ID":14597,"metacyc":"2.7.8.24-RXN","compounds":"a CDP-1,2-diacyl-sn-glycerol + choline => a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)"}
{"X":17788,"RHEA_ID":14599,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+) => a CDP-1,2-diacyl-sn-glycerol + choline"}
{"X":17789,"RHEA_ID":24418,"compounds":"4-hydroxybenzoate + formate + 2 H(+) => 2,4'-dihydroxyacetophenone + O2"}
{"X":17790,"RHEA_ID":14601,"DIRECTION":"UN","MASTER_ID":14601,"ec":"1.13.12.2","compounds":"L-lysine + O2 = 5-aminopentanamide + CO2 + H2O"}
{"X":17791,"RHEA_ID":14602,"DIRECTION":"LR","MASTER_ID":14601,"metacyc":"LYSINE-2-MONOOXYGENASE-RXN","compounds":"L-lysine + O2 => 5-aminopentanamide + CO2 + H2O"}
{"X":17792,"RHEA_ID":14603,"compounds":"5-aminopentanamide + CO2 + H2O => L-lysine + O2"}
{"X":17793,"RHEA_ID":24422,"compounds":"formate + N-terminal L-methionyl-[peptide] => H2O + N-terminal N-formyl-L-methionyl-[peptide]"}
{"X":17794,"RHEA_ID":14605,"DIRECTION":"UN","MASTER_ID":14605,"ec":"2.4.1.36","compounds":"D-glucose 6-phosphate + GDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + GDP + H(+)"}
{"X":17795,"RHEA_ID":14606,"DIRECTION":"LR","MASTER_ID":14605,"metacyc":"2.4.1.36-RXN","compounds":"D-glucose 6-phosphate + GDP-alpha-D-glucose => alpha,alpha-trehalose 6-phosphate + GDP + H(+)"}
{"X":17796,"RHEA_ID":14607,"compounds":"alpha,alpha-trehalose 6-phosphate + GDP + H(+) => D-glucose 6-phosphate + GDP-alpha-D-glucose"}
{"X":17797,"RHEA_ID":24426,"compounds":"glutathione disulfide + L-ascorbate => 2 glutathione + L-dehydroascorbate"}
{"X":17798,"RHEA_ID":14609,"DIRECTION":"UN","MASTER_ID":14609,"ec":"1.1.1.289","compounds":"D-sorbitol + NADP(+) = H(+) + keto-L-sorbose + NADPH"}
{"X":17799,"RHEA_ID":14610,"compounds":"D-sorbitol + NADP(+) => H(+) + keto-L-sorbose + NADPH"}
{"X":17800,"RHEA_ID":14611,"compounds":"H(+) + keto-L-sorbose + NADPH => D-sorbitol + NADP(+)"}
{"X":17801,"RHEA_ID":24434,"compounds":"acetate + H(+) + oxalate => H2O + oxaloacetate"}
{"X":17802,"RHEA_ID":14613,"DIRECTION":"UN","MASTER_ID":14613,"ec":"7.6.2.7","compounds":"ATP + H2O + taurine(out) = ADP + H(+) + phosphate + taurine(in)"}
{"X":17803,"RHEA_ID":14614,"DIRECTION":"LR","MASTER_ID":14613,"ecocyc":"ABC-64-RXN","metacyc":"3.6.3.36-RXN","compounds":"ATP + H2O + taurine(out) => ADP + H(+) + phosphate + taurine(in)"}
{"X":17804,"RHEA_ID":14615,"compounds":"ADP + H(+) + phosphate + taurine(in) => ATP + H2O + taurine(out)"}
{"X":17805,"RHEA_ID":14616,"compounds":"ATP + H2O + taurine(out) <=> ADP + H(+) + phosphate + taurine(in)"}
{"X":17806,"RHEA_ID":14617,"DIRECTION":"UN","MASTER_ID":14617,"ec":"1.8.1.10","compounds":"CoA + glutathione + NADP(+) = CoA-glutathione + H(+) + NADPH"}
{"X":17807,"RHEA_ID":14618,"compounds":"CoA + glutathione + NADP(+) => CoA-glutathione + H(+) + NADPH"}
{"X":17808,"RHEA_ID":14619,"DIRECTION":"RL","MASTER_ID":14617,"metacyc":"COA-GLUTATHIONE-REDUCTASE-NADPH-RXN","compounds":"CoA-glutathione + H(+) + NADPH => CoA + glutathione + NADP(+)"}
{"X":17809,"RHEA_ID":24441,"DIRECTION":"LR","MASTER_ID":24440,"ecocyc":"ABC-27-RXN","metacyc":"3.6.3.27-RXN","compounds":"ATP + H2O + phosphate(out) => ADP + H(+) + 2 phosphate(in)"}
{"X":17810,"RHEA_ID":14621,"DIRECTION":"UN","MASTER_ID":14621,"ec":"5.4.99.7","compounds":"(S)-2,3-epoxysqualene = lanosterol"}
{"X":17811,"RHEA_ID":14622,"DIRECTION":"LR","MASTER_ID":14621,"metacyc":"LANOSTEROL-SYNTHASE-RXN","compounds":"(S)-2,3-epoxysqualene => lanosterol"}
{"X":17812,"RHEA_ID":14623,"compounds":"lanosterol => (S)-2,3-epoxysqualene"}
{"X":17813,"RHEA_ID":24445,"compounds":"GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[(1->4)-alpha-L-Fuc]-beta-D-GlcNAc}-L-asparaginyl-[protein]"}
{"X":17814,"RHEA_ID":14625,"DIRECTION":"UN","MASTER_ID":14625,"ec":"2.4.1.2","metacyc":"DEXTRIN-DEXTRANASE-RXN","compounds":"[(1->4)-alpha-D-glucosyl](n) + [(1->6)-alpha-D-glucosyl](n+1) = [(1->4)-alpha-D-glucosyl](n+1) + [(1->6)-alpha-D-glucosyl](n)"}
{"X":17815,"RHEA_ID":14626,"compounds":"[(1->4)-alpha-D-glucosyl](n) + [(1->6)-alpha-D-glucosyl](n+1) => [(1->4)-alpha-D-glucosyl](n+1) + [(1->6)-alpha-D-glucosyl](n)"}
{"X":17816,"RHEA_ID":14627,"compounds":"[(1->4)-alpha-D-glucosyl](n+1) + [(1->6)-alpha-D-glucosyl](n) => [(1->4)-alpha-D-glucosyl](n) + [(1->6)-alpha-D-glucosyl](n+1)"}
{"X":17817,"RHEA_ID":14629,"DIRECTION":"UN","MASTER_ID":14629,"ec":"2.7.2.8","compounds":"ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate"}
{"X":17818,"RHEA_ID":14630,"DIRECTION":"LR","MASTER_ID":14629,"ecocyc":"ACETYLGLUTKIN-RXN","compounds":"ATP + N-acetyl-L-glutamate => ADP + N-acetyl-L-glutamyl 5-phosphate"}
{"X":17819,"RHEA_ID":14631,"compounds":"ADP + N-acetyl-L-glutamyl 5-phosphate => ATP + N-acetyl-L-glutamate"}
{"X":17820,"RHEA_ID":24453,"DIRECTION":"LR","MASTER_ID":24452,"ecocyc":"CHER-RXN","metacyc":"CHER-RXN","compounds":"L-glutamyl-[protein] + S-adenosyl-L-methionine => [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine"}
{"X":17821,"RHEA_ID":14633,"DIRECTION":"UN","MASTER_ID":14633,"ec":"7.2.2.3","compounds":"ATP + H2O + Na(+)(in) = ADP + H(+) + Na(+)(out) + phosphate"}
{"X":17822,"RHEA_ID":14633,"DIRECTION":"UN","MASTER_ID":14633,"ec":"7.2.2.4","compounds":"ATP + H2O + Na(+)(in) = ADP + H(+) + Na(+)(out) + phosphate"}
{"X":17823,"RHEA_ID":14634,"DIRECTION":"LR","MASTER_ID":14633,"metacyc":"3.6.3.15-RXN","compounds":"ATP + H2O + Na(+)(in) => ADP + H(+) + Na(+)(out) + phosphate"}
{"X":17824,"RHEA_ID":14634,"DIRECTION":"LR","MASTER_ID":14633,"metacyc":"3.6.3.7-RXN","compounds":"ATP + H2O + Na(+)(in) => ADP + H(+) + Na(+)(out) + phosphate"}
{"X":17825,"RHEA_ID":14634,"DIRECTION":"LR","MASTER_ID":14633,"metacyc":"RXN-19779","compounds":"ATP + H2O + Na(+)(in) => ADP + H(+) + Na(+)(out) + phosphate"}
{"X":17826,"RHEA_ID":14635,"compounds":"ADP + H(+) + Na(+)(out) + phosphate => ATP + H2O + Na(+)(in)"}
{"X":17827,"RHEA_ID":14636,"compounds":"ATP + H2O + Na(+)(in) <=> ADP + H(+) + Na(+)(out) + phosphate"}
{"X":17828,"RHEA_ID":14637,"DIRECTION":"UN","MASTER_ID":14637,"ec":"2.8.2.16","metacyc":"THIOL-SULFOTRANSFERASE-RXN","compounds":"3'-phosphoadenylyl sulfate + a thiol = adenosine 3',5'-bisphosphate + H(+) + S-alkyl thiosulfate"}
{"X":17829,"RHEA_ID":14638,"compounds":"3'-phosphoadenylyl sulfate + a thiol => adenosine 3',5'-bisphosphate + H(+) + S-alkyl thiosulfate"}
{"X":17830,"RHEA_ID":14639,"compounds":"adenosine 3',5'-bisphosphate + H(+) + S-alkyl thiosulfate => 3'-phosphoadenylyl sulfate + a thiol"}
{"X":17831,"RHEA_ID":24464,"DIRECTION":"UN","MASTER_ID":24464,"ec":"4.1.2.55","compounds":"2-dehydro-3-deoxy-6-phospho-D-galactonate = D-glyceraldehyde 3-phosphate + pyruvate"}
{"X":17832,"RHEA_ID":14641,"DIRECTION":"UN","MASTER_ID":14641,"ec":"3.5.2.15","compounds":"cyanurate + H2O = biuret + CO2"}
{"X":17833,"RHEA_ID":14642,"DIRECTION":"LR","MASTER_ID":14641,"metacyc":"R468-RXN","compounds":"cyanurate + H2O => biuret + CO2"}
{"X":17834,"RHEA_ID":14643,"compounds":"biuret + CO2 => cyanurate + H2O"}
{"X":17835,"RHEA_ID":14645,"DIRECTION":"UN","MASTER_ID":14645,"ec":"3.3.1.2","compounds":"H2O + S-adenosyl-L-methionine = H(+) + L-homoserine + S-methyl-5'-thioadenosine"}
{"X":17836,"RHEA_ID":14646,"DIRECTION":"LR","MASTER_ID":14645,"metacyc":"ADENOSYLMETHIONINE-HYDROLASE-RXN","compounds":"H2O + S-adenosyl-L-methionine => H(+) + L-homoserine + S-methyl-5'-thioadenosine"}
{"X":17837,"RHEA_ID":14647,"compounds":"H(+) + L-homoserine + S-methyl-5'-thioadenosine => H2O + S-adenosyl-L-methionine"}
{"X":17838,"RHEA_ID":35087,"compounds":"H2O + N'-monoacetylchitobiose-6'-phosphate = D-glucosamine + N-acetyl-D-glucosamine 6-phosphate"}
{"X":17839,"RHEA_ID":14649,"DIRECTION":"UN","MASTER_ID":14649,"ec":"2.4.1.318","compounds":"demethyllactenocin + dTDP-beta-L-mycarose = demethylmacrocin + dTDP + H(+)"}
{"X":17840,"RHEA_ID":14650,"DIRECTION":"LR","MASTER_ID":14649,"metacyc":"RXN-15058","compounds":"demethyllactenocin + dTDP-beta-L-mycarose => demethylmacrocin + dTDP + H(+)"}
{"X":17841,"RHEA_ID":14651,"compounds":"demethylmacrocin + dTDP + H(+) => demethyllactenocin + dTDP-beta-L-mycarose"}
{"X":17842,"RHEA_ID":14653,"DIRECTION":"UN","MASTER_ID":14653,"ec":"3.1.4.17","compounds":"a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+)"}
{"X":17843,"RHEA_ID":14654,"DIRECTION":"LR","MASTER_ID":14653,"metacyc":"3.1.4.17-RXN","compounds":"a nucleoside 3',5'-cyclic phosphate + H2O => a nucleoside 5'-phosphate + H(+)"}
{"X":17844,"RHEA_ID":14655,"compounds":"a nucleoside 5'-phosphate + H(+) => a nucleoside 3',5'-cyclic phosphate + H2O"}
{"X":17845,"RHEA_ID":14657,"DIRECTION":"UN","MASTER_ID":14657,"ec":"5.3.1.6","compounds":"aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate"}
{"X":17846,"RHEA_ID":14658,"compounds":"aldehydo-D-ribose 5-phosphate => D-ribulose 5-phosphate"}
{"X":17847,"RHEA_ID":14659,"compounds":"D-ribulose 5-phosphate => aldehydo-D-ribose 5-phosphate"}
{"X":17848,"RHEA_ID":14661,"compounds":"octadecanal = CO + heptadecane"}
{"X":17849,"RHEA_ID":14662,"DIRECTION":"LR","MASTER_ID":14661,"metacyc":"OCTADECANAL-DECARBONYLASE-RXN","compounds":"octadecanal => CO + heptadecane"}
{"X":17850,"RHEA_ID":14663,"compounds":"CO + heptadecane => octadecanal"}
{"X":17851,"RHEA_ID":35103,"compounds":"fusidate(in) = fusidate(out)"}
{"X":17852,"RHEA_ID":14665,"DIRECTION":"UN","MASTER_ID":14665,"ec":"3.5.4.3","compounds":"guanine + H(+) + H2O = NH4(+) + xanthine"}
{"X":17853,"RHEA_ID":14666,"DIRECTION":"LR","MASTER_ID":14665,"ecocyc":"GUANINE-DEAMINASE-RXN","metacyc":"GUANINE-DEAMINASE-RXN","reactome":"R-HSA-74255.4","compounds":"guanine + H(+) + H2O => NH4(+) + xanthine"}
{"X":17854,"RHEA_ID":14667,"compounds":"NH4(+) + xanthine => guanine + H(+) + H2O"}
{"X":17855,"RHEA_ID":35107,"DIRECTION":"UN","MASTER_ID":35107,"ec":"1.4.3.21","compounds":"3-nitrotyramine + H2O + O2 = 4-hydroxy-3-nitrophenylacetaldehyde + H2O2 + NH4(+)"}
{"X":17856,"RHEA_ID":14669,"DIRECTION":"UN","MASTER_ID":14669,"ec":"1.2.1.9","compounds":"D-glyceraldehyde 3-phosphate + H2O + NADP(+) = (2R)-3-phosphoglycerate + 2 H(+) + NADPH"}
{"X":17857,"RHEA_ID":14669,"DIRECTION":"UN","MASTER_ID":14669,"ec":"1.2.1.90","compounds":"D-glyceraldehyde 3-phosphate + H2O + NADP(+) = (2R)-3-phosphoglycerate + 2 H(+) + NADPH"}
{"X":17858,"RHEA_ID":14670,"DIRECTION":"LR","MASTER_ID":14669,"metacyc":"1.2.1.9-RXN","compounds":"D-glyceraldehyde 3-phosphate + H2O + NADP(+) => (2R)-3-phosphoglycerate + 2 H(+) + NADPH"}
{"X":17859,"RHEA_ID":14671,"compounds":"(2R)-3-phosphoglycerate + 2 H(+) + NADPH => D-glyceraldehyde 3-phosphate + H2O + NADP(+)"}
{"X":17860,"RHEA_ID":24500,"DIRECTION":"UN","MASTER_ID":24500,"ec":"3.6.1.14","compounds":"adenosine 5'-tetraphosphate + H2O = ATP + H(+) + phosphate"}
{"X":17861,"RHEA_ID":14673,"DIRECTION":"UN","MASTER_ID":14673,"ec":"7.4.2.1","compounds":"a polar amino acid(out) + ATP + H2O = a polar amino acid(in) + ADP + H(+) + phosphate"}
{"X":17862,"RHEA_ID":14674,"compounds":"a polar amino acid(out) + ATP + H2O => a polar amino acid(in) + ADP + H(+) + phosphate"}
{"X":17863,"RHEA_ID":14675,"compounds":"a polar amino acid(in) + ADP + H(+) + phosphate => a polar amino acid(out) + ATP + H2O"}
{"X":17864,"RHEA_ID":24504,"DIRECTION":"UN","MASTER_ID":24504,"ec":"1.13.11.54","compounds":"1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)"}
{"X":17865,"RHEA_ID":14677,"DIRECTION":"UN","MASTER_ID":14677,"ec":"5.1.3.12","compounds":"UDP-alpha-D-glucuronate = UDP-beta-L-iduronate"}
{"X":17866,"RHEA_ID":14678,"compounds":"UDP-alpha-D-glucuronate => UDP-beta-L-iduronate"}
{"X":17867,"RHEA_ID":14679,"compounds":"UDP-beta-L-iduronate => UDP-alpha-D-glucuronate"}
{"X":17868,"RHEA_ID":24508,"DIRECTION":"UN","MASTER_ID":24508,"ec":"1.1.1.189","compounds":"NADP(+) + prostaglandin F2alpha = H(+) + NADPH + prostaglandin E2"}
{"X":17869,"RHEA_ID":14681,"compounds":"2 2-aminophenol + A + O2 = 2-aminophenoxazin-3-one + AH2 + 2 H2O"}
{"X":17870,"RHEA_ID":14682,"compounds":"2 2-aminophenol + A + O2 => 2-aminophenoxazin-3-one + AH2 + 2 H2O"}
{"X":17871,"RHEA_ID":14683,"compounds":"2-aminophenoxazin-3-one + AH2 + 2 H2O => 2 2-aminophenol + A + O2"}
{"X":17872,"RHEA_ID":24512,"DIRECTION":"UN","MASTER_ID":24512,"ec":"4.2.1.50","compounds":"L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + H2O"}
{"X":17873,"RHEA_ID":14685,"DIRECTION":"UN","MASTER_ID":14685,"ec":"1.1.99.20","metacyc":"ALKAN-1-OL-DEHYDROGENASE-ACCEPTOR-RXN","compounds":"A + a primary alcohol = AH2 + an aldehyde"}
{"X":17874,"RHEA_ID":14686,"compounds":"A + a primary alcohol => AH2 + an aldehyde"}
{"X":17875,"RHEA_ID":14687,"compounds":"AH2 + an aldehyde => A + a primary alcohol"}
{"X":17876,"RHEA_ID":14689,"DIRECTION":"UN","MASTER_ID":14689,"ec":"1.14.12.9","compounds":"4-chlorophenylacetate + NADH + O2 = 3,4-dihydroxyphenylacetate + chloride + NAD(+)"}
{"X":17877,"RHEA_ID":14690,"DIRECTION":"LR","MASTER_ID":14689,"metacyc":"1.14.12.9-RXN","compounds":"4-chlorophenylacetate + NADH + O2 => 3,4-dihydroxyphenylacetate + chloride + NAD(+)"}
{"X":17878,"RHEA_ID":14691,"compounds":"3,4-dihydroxyphenylacetate + chloride + NAD(+) => 4-chlorophenylacetate + NADH + O2"}
{"X":17879,"RHEA_ID":24520,"DIRECTION":"UN","MASTER_ID":24520,"ec":"1.5.1.9","compounds":"H2O + L-saccharopine + NAD(+) = (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADH"}
{"X":17880,"RHEA_ID":14693,"DIRECTION":"UN","MASTER_ID":14693,"ec":"2.4.1.153","compounds":"dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP"}
{"X":17881,"RHEA_ID":14694,"compounds":"dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine => dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP"}
{"X":17882,"RHEA_ID":14695,"compounds":"dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP => dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":17883,"RHEA_ID":24524,"DIRECTION":"UN","MASTER_ID":24524,"ec":"1.14.15.34","compounds":"20-oxo-5-O-beta-D-mycaminosyltylonolide + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 5-O-beta-D-mycaminosyltylonolide + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":17884,"RHEA_ID":14697,"DIRECTION":"UN","MASTER_ID":14697,"ec":"1.1.1.216","compounds":"(2E,6E)-farnesol + NADP(+) = (2E,6E)-farnesal + H(+) + NADPH"}
{"X":17885,"RHEA_ID":14698,"compounds":"(2E,6E)-farnesol + NADP(+) => (2E,6E)-farnesal + H(+) + NADPH"}
{"X":17886,"RHEA_ID":14699,"compounds":"(2E,6E)-farnesal + H(+) + NADPH => (2E,6E)-farnesol + NADP(+)"}
{"X":17887,"RHEA_ID":24528,"DIRECTION":"UN","MASTER_ID":24528,"ec":"1.1.1.78","compounds":"(R)-lactaldehyde + NAD(+) = H(+) + methylglyoxal + NADH"}
{"X":17888,"RHEA_ID":14701,"compounds":"2 CoA + NAD(+) = CoA-disulfide + H(+) + NADH"}
{"X":17889,"RHEA_ID":14702,"compounds":"2 CoA + NAD(+) => CoA-disulfide + H(+) + NADH"}
{"X":17890,"RHEA_ID":14703,"compounds":"CoA-disulfide + H(+) + NADH => 2 CoA + NAD(+)"}
{"X":17891,"RHEA_ID":14704,"compounds":"2 CoA + NAD(+) <=> CoA-disulfide + H(+) + NADH"}
{"X":17892,"RHEA_ID":14705,"DIRECTION":"UN","MASTER_ID":14705,"ec":"1.8.1.14","compounds":"2 CoA + NADP(+) = CoA-disulfide + H(+) + NADPH"}
{"X":17893,"RHEA_ID":14706,"compounds":"2 CoA + NADP(+) => CoA-disulfide + H(+) + NADPH"}
{"X":17894,"RHEA_ID":14707,"compounds":"CoA-disulfide + H(+) + NADPH => 2 CoA + NADP(+)"}
{"X":17895,"RHEA_ID":14708,"compounds":"2 CoA + NADP(+) <=> CoA-disulfide + H(+) + NADPH"}
{"X":17896,"RHEA_ID":14709,"DIRECTION":"UN","MASTER_ID":14709,"ec":"5.3.3.1","compounds":"a 3-oxo-Delta(5)-steroid = a 3-oxo-Delta(4)-steroid"}
{"X":17897,"RHEA_ID":14710,"compounds":"a 3-oxo-Delta(5)-steroid => a 3-oxo-Delta(4)-steroid"}
{"X":17898,"RHEA_ID":14711,"compounds":"a 3-oxo-Delta(4)-steroid => a 3-oxo-Delta(5)-steroid"}
{"X":17899,"RHEA_ID":35152,"compounds":"4-hydroxy-3-nitrophenylacetaldehyde + H2O + NAD(+) => (3-nitro-4-oxidophenyl)acetate + 2 H(+) + NADH"}
{"X":17900,"RHEA_ID":14713,"DIRECTION":"UN","MASTER_ID":14713,"ec":"1.1.99.12","metacyc":"SORBOSE-DEHYDROGENASE-RXN","compounds":"A + keto-L-sorbose = 5-dehydro-D-fructose + AH2"}
{"X":17901,"RHEA_ID":14714,"compounds":"A + keto-L-sorbose => 5-dehydro-D-fructose + AH2"}
{"X":17902,"RHEA_ID":14715,"compounds":"5-dehydro-D-fructose + AH2 => A + keto-L-sorbose"}
{"X":17903,"RHEA_ID":35156,"DIRECTION":"LR","MASTER_ID":35155,"ecocyc":"RXN-10015","metacyc":"RXN-10015","compounds":"(S)-4,5-dihydroxypentane-2,3-dione => (2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one"}
{"X":17904,"RHEA_ID":14717,"DIRECTION":"UN","MASTER_ID":14717,"ec":"2.5.1.54","compounds":"D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate"}
{"X":17905,"RHEA_ID":14718,"compounds":"D-erythrose 4-phosphate + H2O + phosphoenolpyruvate => 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate"}
{"X":17906,"RHEA_ID":14719,"compounds":"7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate => D-erythrose 4-phosphate + H2O + phosphoenolpyruvate"}
{"X":17907,"RHEA_ID":14721,"DIRECTION":"UN","MASTER_ID":14721,"ec":"2.4.2.40","compounds":"UDP-alpha-D-xylose + zeatin = H(+) + O-beta-D-xylosylzeatin + UDP"}
{"X":17908,"RHEA_ID":14722,"compounds":"UDP-alpha-D-xylose + zeatin => H(+) + O-beta-D-xylosylzeatin + UDP"}
{"X":17909,"RHEA_ID":14723,"compounds":"H(+) + O-beta-D-xylosylzeatin + UDP => UDP-alpha-D-xylose + zeatin"}
{"X":17910,"RHEA_ID":14725,"DIRECTION":"UN","MASTER_ID":14725,"ec":"2.5.1.17","compounds":"2 ATP + 2 cob(II)inamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)inamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate"}
{"X":17911,"RHEA_ID":14726,"DIRECTION":"LR","MASTER_ID":14725,"ecocyc":"BTUR2-RXN","metacyc":"BTUR2-RXN","compounds":"2 ATP + 2 cob(II)inamide + reduced [electron-transfer flavoprotein] => 2 adenosylcob(III)inamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate"}
{"X":17912,"RHEA_ID":14727,"compounds":"2 adenosylcob(III)inamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate => 2 ATP + 2 cob(II)inamide + reduced [electron-transfer flavoprotein]"}
{"X":17913,"RHEA_ID":14729,"DIRECTION":"UN","MASTER_ID":14729,"ec":"4.1.2.13","compounds":"beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate"}
{"X":17914,"RHEA_ID":14730,"compounds":"beta-D-fructose 1,6-bisphosphate => D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate"}
{"X":17915,"RHEA_ID":14731,"compounds":"D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate => beta-D-fructose 1,6-bisphosphate"}
{"X":17916,"RHEA_ID":35172,"compounds":"H(+)(out) + novobiocin(in) => H(+)(in) + novobiocin(out)"}
{"X":17917,"RHEA_ID":14733,"DIRECTION":"UN","MASTER_ID":14733,"ec":"7.2.2.15","compounds":"Ag(+)(in) + ATP + H2O = ADP + Ag(+)(out) + H(+) + phosphate"}
{"X":17918,"RHEA_ID":14734,"DIRECTION":"LR","MASTER_ID":14733,"ecocyc":"3.6.3.53-RXN","metacyc":"3.6.3.53-RXN","compounds":"Ag(+)(in) + ATP + H2O => ADP + Ag(+)(out) + H(+) + phosphate"}
{"X":17919,"RHEA_ID":14735,"compounds":"ADP + Ag(+)(out) + H(+) + phosphate => Ag(+)(in) + ATP + H2O"}
{"X":17920,"RHEA_ID":35176,"compounds":"novobiocin(in) => novobiocin(out)"}
{"X":17921,"RHEA_ID":14737,"DIRECTION":"UN","MASTER_ID":14737,"ec":"4.6.1.6","metacyc":"CYTIDYLATE-CYCLASE-RXN","compounds":"CTP = 3',5'-cyclic CMP + diphosphate"}
{"X":17922,"RHEA_ID":14738,"compounds":"CTP => 3',5'-cyclic CMP + diphosphate"}
{"X":17923,"RHEA_ID":14739,"compounds":"3',5'-cyclic CMP + diphosphate => CTP"}
{"X":17924,"RHEA_ID":35180,"DIRECTION":"LR","MASTER_ID":35179,"metacyc":"RXN-9479","compounds":"6 H(+) + hexanoyl-[ACP] + 7 malonyl-CoA => 7 CO2 + 7 CoA + 2 H2O + holo-[ACP] + noranthrone"}
{"X":17925,"RHEA_ID":14741,"DIRECTION":"UN","MASTER_ID":14741,"ec":"3.5.1.67","compounds":"4-methylene-L-glutamine + H2O = 4-methylene-L-glutamate + NH4(+)"}
{"X":17926,"RHEA_ID":14742,"DIRECTION":"LR","MASTER_ID":14741,"metacyc":"4-METHYLENEGLUTAMINASE-RXN","compounds":"4-methylene-L-glutamine + H2O => 4-methylene-L-glutamate + NH4(+)"}
{"X":17927,"RHEA_ID":14743,"compounds":"4-methylene-L-glutamate + NH4(+) => 4-methylene-L-glutamine + H2O"}
{"X":17928,"RHEA_ID":14749,"DIRECTION":"UN","MASTER_ID":14749,"ec":"1.13.11.38","compounds":"1-hydroxy-2-naphthoate + O2 = (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H(+)"}
{"X":17929,"RHEA_ID":14750,"compounds":"1-hydroxy-2-naphthoate + O2 => (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H(+)"}
{"X":17930,"RHEA_ID":14751,"compounds":"(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H(+) => 1-hydroxy-2-naphthoate + O2"}
{"X":17931,"RHEA_ID":35188,"DIRECTION":"LR","MASTER_ID":35187,"ecocyc":"RXN0-6461","metacyc":"RXN0-6461","compounds":"(Z)-3-aminoperacrylic acid + AH2 => (Z)-3-aminoacrylate + A + H(+) + H2O"}
{"X":17932,"RHEA_ID":14753,"DIRECTION":"UN","MASTER_ID":14753,"ec":"1.14.14.32","compounds":"17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] = acetate + androst-4-ene-3,17-dione + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":17933,"RHEA_ID":14754,"DIRECTION":"LR","MASTER_ID":14753,"metacyc":"4.1.2.30-RXN","compounds":"17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] => acetate + androst-4-ene-3,17-dione + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":17934,"RHEA_ID":14755,"compounds":"acetate + androst-4-ene-3,17-dione + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":17935,"RHEA_ID":14757,"compounds":"2 [Fe(III)cytochrome c] + L-galactono-1,4-lactone = 2 [Fe(II)cytochrome c] + 3 H(+) + L-ascorbate"}
{"X":17936,"RHEA_ID":14758,"DIRECTION":"LR","MASTER_ID":14757,"metacyc":"GALACTONOLACTONE-DEHYDROGENASE-RXN","compounds":"2 [Fe(III)cytochrome c] + L-galactono-1,4-lactone => 2 [Fe(II)cytochrome c] + 3 H(+) + L-ascorbate"}
{"X":17937,"RHEA_ID":14759,"compounds":"2 [Fe(II)cytochrome c] + 3 H(+) + L-ascorbate => 2 [Fe(III)cytochrome c] + L-galactono-1,4-lactone"}
{"X":17938,"RHEA_ID":24581,"DIRECTION":"LR","MASTER_ID":24580,"metacyc":"SORBITOL-6-PHOSPHATASE-RXN","compounds":"D-sorbitol 6-phosphate + H2O => D-sorbitol + phosphate"}
{"X":17939,"RHEA_ID":14761,"DIRECTION":"UN","MASTER_ID":14761,"ec":"2.3.1.50","compounds":"H(+) + hexadecanoyl-CoA + L-serine = 3-oxosphinganine + CO2 + CoA"}
{"X":17940,"RHEA_ID":14762,"DIRECTION":"LR","MASTER_ID":14761,"metacyc":"SERINE-C-PALMITOYLTRANSFERASE-RXN","compounds":"H(+) + hexadecanoyl-CoA + L-serine => 3-oxosphinganine + CO2 + CoA"}
{"X":17941,"RHEA_ID":14763,"compounds":"3-oxosphinganine + CO2 + CoA => H(+) + hexadecanoyl-CoA + L-serine"}
{"X":17942,"RHEA_ID":24585,"DIRECTION":"LR","MASTER_ID":24584,"metacyc":"1.2.1.40-RXN","compounds":"(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + H2O + NAD(+) => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + 2 H(+) + NADH"}
{"X":17943,"RHEA_ID":14765,"DIRECTION":"UN","MASTER_ID":14765,"ec":"1.13.12.5","compounds":"coelenterazine h + O2 = CO2 + excited coelenteramide h monoanion + H(+) + hnu"}
{"X":17944,"RHEA_ID":14766,"DIRECTION":"LR","MASTER_ID":14765,"metacyc":"RENILLA-LUCIFERIN-2-MONOOXYGENASE-RXN","compounds":"coelenterazine h + O2 => CO2 + excited coelenteramide h monoanion + H(+) + hnu"}
{"X":17945,"RHEA_ID":14767,"compounds":"CO2 + excited coelenteramide h monoanion + H(+) + hnu => coelenterazine h + O2"}
{"X":17946,"RHEA_ID":24589,"compounds":"ATP + D-arabinose => ADP + D-arabinose 5-phosphate + H(+)"}
{"X":17947,"RHEA_ID":14769,"DIRECTION":"UN","MASTER_ID":14769,"ec":"1.5.99.4","compounds":"(S)-nicotine + A + H2O = (S)-6-hydroxynicotine + AH2"}
{"X":17948,"RHEA_ID":14770,"DIRECTION":"LR","MASTER_ID":14769,"metacyc":"NICOTINE-DEHYDROGENASE-RXN","compounds":"(S)-nicotine + A + H2O => (S)-6-hydroxynicotine + AH2"}
{"X":17949,"RHEA_ID":14771,"compounds":"(S)-6-hydroxynicotine + AH2 => (S)-nicotine + A + H2O"}
{"X":17950,"RHEA_ID":24593,"DIRECTION":"LR","MASTER_ID":24592,"metacyc":"2.7.7.14-RXN","reactome":"R-HSA-1483190.1","compounds":"CTP + H(+) + phosphoethanolamine => CDP-ethanolamine + diphosphate"}
{"X":17951,"RHEA_ID":14773,"DIRECTION":"UN","MASTER_ID":14773,"ec":"2.1.1.147","compounds":"2 NADPH + palmatine + S-adenosyl-L-methionine = corydaline + 2 NADP(+) + S-adenosyl-L-homocysteine"}
{"X":17952,"RHEA_ID":14774,"DIRECTION":"LR","MASTER_ID":14773,"metacyc":"2.1.1.147-RXN","compounds":"2 NADPH + palmatine + S-adenosyl-L-methionine => corydaline + 2 NADP(+) + S-adenosyl-L-homocysteine"}
{"X":17953,"RHEA_ID":14775,"compounds":"corydaline + 2 NADP(+) + S-adenosyl-L-homocysteine => 2 NADPH + palmatine + S-adenosyl-L-methionine"}
{"X":17954,"RHEA_ID":24597,"compounds":"acetyl-CoA + L-histidine => CoA + H(+) + N(alpha)-acetyl-L-histidine"}
{"X":17955,"RHEA_ID":14777,"DIRECTION":"UN","MASTER_ID":14777,"ec":"3.5.4.6","compounds":"AMP + H(+) + H2O = IMP + NH4(+)"}
{"X":17956,"RHEA_ID":14777,"DIRECTION":"UN","MASTER_ID":14777,"ec":"3.5.4.17","compounds":"AMP + H(+) + H2O = IMP + NH4(+)"}
{"X":17957,"RHEA_ID":14778,"DIRECTION":"LR","MASTER_ID":14777,"metacyc":"AMP-DEAMINASE-RXN","reactome":"R-HSA-76590.4","compounds":"AMP + H(+) + H2O => IMP + NH4(+)"}
{"X":17958,"RHEA_ID":14779,"compounds":"IMP + NH4(+) => AMP + H(+) + H2O"}
{"X":17959,"RHEA_ID":24602,"compounds":"H2O2 + sulfate => H2O + O2 + sulfite"}
{"X":17960,"RHEA_ID":14781,"DIRECTION":"UN","MASTER_ID":14781,"ec":"6.2.1.14","compounds":"ATP + CoA + heptanedioate = 6-carboxyhexanoyl-CoA + AMP + diphosphate"}
{"X":17961,"RHEA_ID":14782,"compounds":"ATP + CoA + heptanedioate => 6-carboxyhexanoyl-CoA + AMP + diphosphate"}
{"X":17962,"RHEA_ID":14783,"compounds":"6-carboxyhexanoyl-CoA + AMP + diphosphate => ATP + CoA + heptanedioate"}
{"X":17963,"RHEA_ID":24605,"DIRECTION":"LR","MASTER_ID":24604,"metacyc":"RXN-7598","compounds":"7-methylxanthine + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + theobromine"}
{"X":17964,"RHEA_ID":14785,"DIRECTION":"UN","MASTER_ID":14785,"ec":"2.7.7.52","compounds":"RNA(n) + UTP = diphosphate + RNA(n)-3'-uridine ribonucleotide"}
{"X":17965,"RHEA_ID":14786,"compounds":"RNA(n) + UTP => diphosphate + RNA(n)-3'-uridine ribonucleotide"}
{"X":17966,"RHEA_ID":14787,"compounds":"diphosphate + RNA(n)-3'-uridine ribonucleotide => RNA(n) + UTP"}
{"X":17967,"RHEA_ID":14789,"DIRECTION":"UN","MASTER_ID":14789,"ec":"2.4.1.198","compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine = a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP"}
{"X":17968,"RHEA_ID":14790,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP"}
{"X":17969,"RHEA_ID":14791,"compounds":"a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":17970,"RHEA_ID":24613,"compounds":"17beta-estradiol + NAD(+) => estrone + H(+) + NADH"}
{"X":17971,"RHEA_ID":14793,"DIRECTION":"UN","MASTER_ID":14793,"ec":"1.1.1.172","metacyc":"2-OXOADIPATE-REDUCTASE-RXN","compounds":"2-hydroxyadipate + NAD(+) = 2-oxoadipate + H(+) + NADH"}
{"X":17972,"RHEA_ID":14794,"compounds":"2-hydroxyadipate + NAD(+) => 2-oxoadipate + H(+) + NADH"}
{"X":17973,"RHEA_ID":14795,"compounds":"2-oxoadipate + H(+) + NADH => 2-hydroxyadipate + NAD(+)"}
{"X":17974,"RHEA_ID":24617,"DIRECTION":"LR","MASTER_ID":24616,"reactome":"R-HSA-5693390.1","compounds":"17beta-estradiol + NADP(+) => estrone + H(+) + NADPH"}
{"X":17975,"RHEA_ID":14797,"DIRECTION":"UN","MASTER_ID":14797,"ec":"2.7.1.178","compounds":"2-dehydro-3-deoxy-D-gluconate + ATP = 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + H(+)"}
{"X":17976,"RHEA_ID":14797,"DIRECTION":"UN","MASTER_ID":14797,"ec":"2.7.1.45","compounds":"2-dehydro-3-deoxy-D-gluconate + ATP = 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + H(+)"}
{"X":17977,"RHEA_ID":14798,"DIRECTION":"LR","MASTER_ID":14797,"ecocyc":"DEOXYGLUCONOKIN-RXN","metacyc":"DEOXYGLUCONOKIN-RXN","compounds":"2-dehydro-3-deoxy-D-gluconate + ATP => 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + H(+)"}
{"X":17978,"RHEA_ID":14799,"compounds":"2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + H(+) => 2-dehydro-3-deoxy-D-gluconate + ATP"}
{"X":17979,"RHEA_ID":35242,"compounds":"tetracycline(in) <=> tetracycline(out)"}
{"X":17980,"RHEA_ID":14801,"DIRECTION":"UN","MASTER_ID":14801,"ec":"2.7.2.3","compounds":"(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP"}
{"X":17981,"RHEA_ID":14802,"DIRECTION":"LR","MASTER_ID":14801,"reactome":"R-HSA-70486.4","compounds":"(2R)-3-phosphoglycerate + ATP => (2R)-3-phospho-glyceroyl phosphate + ADP"}
{"X":17982,"RHEA_ID":14803,"DIRECTION":"RL","MASTER_ID":14801,"macie":"M0040","reactome":"R-HSA-71850.5","compounds":"(2R)-3-phospho-glyceroyl phosphate + ADP => (2R)-3-phosphoglycerate + ATP"}
{"X":17983,"RHEA_ID":35246,"DIRECTION":"BI","MASTER_ID":35243,"ecocyc":"RXN0-5291","metacyc":"RXN0-5291","compounds":"ADP + H(+) + thiamine diphosphate <=> adenosine thiamine triphosphate + phosphate"}
{"X":17984,"RHEA_ID":14805,"DIRECTION":"UN","MASTER_ID":14805,"ec":"2.7.1.55","compounds":"ATP + D-allose = ADP + D-allose 6-phosphate + H(+)"}
{"X":17985,"RHEA_ID":14806,"DIRECTION":"LR","MASTER_ID":14805,"ecocyc":"ALLOSE-KINASE-RXN","metacyc":"ALLOSE-KINASE-RXN","compounds":"ATP + D-allose => ADP + D-allose 6-phosphate + H(+)"}
{"X":17986,"RHEA_ID":14807,"compounds":"ADP + D-allose 6-phosphate + H(+) => ATP + D-allose"}
{"X":17987,"RHEA_ID":35250,"compounds":"alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA(in) + ATP + H2O <=> ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA(out) + H(+) + phosphate"}
{"X":17988,"RHEA_ID":14809,"DIRECTION":"UN","MASTER_ID":14809,"ec":"2.1.1.25","compounds":"phenol + S-adenosyl-L-methionine = anisole + H(+) + S-adenosyl-L-homocysteine"}
{"X":17989,"RHEA_ID":14810,"DIRECTION":"LR","MASTER_ID":14809,"metacyc":"PHENOL-O-METHYLTRANSFERASE-RXN","compounds":"phenol + S-adenosyl-L-methionine => anisole + H(+) + S-adenosyl-L-homocysteine"}
{"X":17990,"RHEA_ID":14811,"compounds":"anisole + H(+) + S-adenosyl-L-homocysteine => phenol + S-adenosyl-L-methionine"}
{"X":17991,"RHEA_ID":24630,"DIRECTION":"RL","MASTER_ID":24628,"ecocyc":"RXN-13854","metacyc":"RXN-13854","compounds":"5 H(+) + 3 NADH + nitrite => 2 H2O + 3 NAD(+) + NH4(+)"}
{"X":17992,"RHEA_ID":14813,"DIRECTION":"UN","MASTER_ID":14813,"ec":"5.1.1.15","compounds":"L-2-aminohexano-6-lactam = D-2-aminohexano-6-lactam"}
{"X":17993,"RHEA_ID":14814,"compounds":"L-2-aminohexano-6-lactam => D-2-aminohexano-6-lactam"}
{"X":17994,"RHEA_ID":14815,"compounds":"D-2-aminohexano-6-lactam => L-2-aminohexano-6-lactam"}
{"X":17995,"RHEA_ID":24633,"compounds":"2 H2O + 3 NADP(+) + NH4(+) => 5 H(+) + 3 NADPH + nitrite"}
{"X":17996,"RHEA_ID":14817,"DIRECTION":"UN","MASTER_ID":14817,"ec":"5.2.1.2","compounds":"4-maleylacetoacetate = 4-fumarylacetoacetate"}
{"X":17997,"RHEA_ID":14818,"DIRECTION":"LR","MASTER_ID":14817,"metacyc":"MALEYLACETOACETATE-ISOMERASE-RXN","reactome":"R-HSA-71173.4","compounds":"4-maleylacetoacetate => 4-fumarylacetoacetate"}
{"X":17998,"RHEA_ID":14819,"compounds":"4-fumarylacetoacetate => 4-maleylacetoacetate"}
{"X":17999,"RHEA_ID":24636,"DIRECTION":"UN","MASTER_ID":24636,"ec":"1.12.1.5","compounds":"H2 + NAD(+) = H(+) + NADH"}
{"X":18000,"RHEA_ID":14821,"DIRECTION":"UN","MASTER_ID":14821,"ec":"5.3.1.4","compounds":"L-arabinose = L-ribulose"}
{"X":18001,"RHEA_ID":14822,"compounds":"L-arabinose => L-ribulose"}
{"X":18002,"RHEA_ID":14823,"compounds":"L-ribulose => L-arabinose"}
{"X":18003,"RHEA_ID":14825,"DIRECTION":"UN","MASTER_ID":14825,"ec":"1.1.1.275","compounds":"(1R,5S)-carveol + NAD(+) = (S)-carvone + H(+) + NADH"}
{"X":18004,"RHEA_ID":14826,"DIRECTION":"LR","MASTER_ID":14825,"metacyc":"RXN-9397","compounds":"(1R,5S)-carveol + NAD(+) => (S)-carvone + H(+) + NADH"}
{"X":18005,"RHEA_ID":14827,"compounds":"(S)-carvone + H(+) + NADH => (1R,5S)-carveol + NAD(+)"}
{"X":18006,"RHEA_ID":24643,"compounds":"ergosteryl 3-beta-D-glucoside + H2O <=> D-glucose + ergosterol"}
{"X":18007,"RHEA_ID":14829,"DIRECTION":"UN","MASTER_ID":14829,"ec":"2.5.1.47","compounds":"hydrogen sulfide + O-acetyl-L-serine = acetate + L-cysteine"}
{"X":18008,"RHEA_ID":14830,"compounds":"hydrogen sulfide + O-acetyl-L-serine => acetate + L-cysteine"}
{"X":18009,"RHEA_ID":14831,"compounds":"acetate + L-cysteine => hydrogen sulfide + O-acetyl-L-serine"}
{"X":18010,"RHEA_ID":24662,"compounds":"H2O + N(omega)-hydroxy-L-arginine + NADP(+) => H(+) + L-arginine + NADPH + O2"}
{"X":18011,"RHEA_ID":14833,"DIRECTION":"UN","MASTER_ID":14833,"ec":"1.1.1.88","compounds":"(R)-mevalonate + CoA + 2 NAD(+) = (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH"}
{"X":18012,"RHEA_ID":14834,"DIRECTION":"LR","MASTER_ID":14833,"metacyc":"HYDROXYMETHYLGLUTARYL-COA-REDUCTASE-RXN","compounds":"(R)-mevalonate + CoA + 2 NAD(+) => (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH"}
{"X":18013,"RHEA_ID":14835,"compounds":"(3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH => (R)-mevalonate + CoA + 2 NAD(+)"}
{"X":18014,"RHEA_ID":24665,"DIRECTION":"LR","MASTER_ID":24664,"metacyc":"RXN-13565","compounds":"2 N(omega)-hydroxy-L-arginine + NADPH + 2 O2 => H(+) + 2 H2O + 2 L-citrulline + NADP(+) + 2 nitric oxide"}
{"X":18015,"RHEA_ID":14837,"DIRECTION":"UN","MASTER_ID":14837,"ec":"1.2.3.5","compounds":"glyoxylate + H2O + O2 = H(+) + H2O2 + oxalate"}
{"X":18016,"RHEA_ID":14838,"DIRECTION":"LR","MASTER_ID":14837,"metacyc":"GLYOXYLATE-OXIDASE-RXN","reactome":"R-HSA-389862.3","compounds":"glyoxylate + H2O + O2 => H(+) + H2O2 + oxalate"}
{"X":18017,"RHEA_ID":14839,"compounds":"H(+) + H2O2 + oxalate => glyoxylate + H2O + O2"}
{"X":18018,"RHEA_ID":14841,"DIRECTION":"UN","MASTER_ID":14841,"ec":"5.5.1.13","compounds":"all-trans-geranylgeranyl diphosphate = ent-copalyl diphosphate"}
{"X":18019,"RHEA_ID":14842,"DIRECTION":"LR","MASTER_ID":14841,"metacyc":"5.5.1.13-RXN","compounds":"all-trans-geranylgeranyl diphosphate => ent-copalyl diphosphate"}
{"X":18020,"RHEA_ID":14843,"compounds":"ent-copalyl diphosphate => all-trans-geranylgeranyl diphosphate"}
{"X":18021,"RHEA_ID":24674,"DIRECTION":"UN","MASTER_ID":24674,"ec":"2.7.1.48","compounds":"ATP + cytidine = ADP + CMP + H(+)"}
{"X":18022,"RHEA_ID":14845,"compounds":"L-aspartate 4-semialdehyde + pyruvate = (S)-2,3-dihydrodipicolinate + H(+) + 2 H2O"}
{"X":18023,"RHEA_ID":14846,"compounds":"L-aspartate 4-semialdehyde + pyruvate => (S)-2,3-dihydrodipicolinate + H(+) + 2 H2O"}
{"X":18024,"RHEA_ID":14847,"compounds":"(S)-2,3-dihydrodipicolinate + H(+) + 2 H2O => L-aspartate 4-semialdehyde + pyruvate"}
{"X":18025,"RHEA_ID":14848,"compounds":"L-aspartate 4-semialdehyde + pyruvate <=> (S)-2,3-dihydrodipicolinate + H(+) + 2 H2O"}
{"X":18026,"RHEA_ID":14849,"DIRECTION":"UN","MASTER_ID":14849,"ec":"3.5.3.14","metacyc":"AMIDINOASPARTASE-RXN","compounds":"H2O + N-amidino-L-aspartate = L-aspartate + urea"}
{"X":18027,"RHEA_ID":14850,"compounds":"H2O + N-amidino-L-aspartate => L-aspartate + urea"}
{"X":18028,"RHEA_ID":14851,"compounds":"L-aspartate + urea => H2O + N-amidino-L-aspartate"}
{"X":18029,"RHEA_ID":24682,"compounds":"5,10-methylenetetrahydromethanopterin + NADP(+) = 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADPH"}
{"X":18030,"RHEA_ID":14853,"DIRECTION":"UN","MASTER_ID":14853,"ec":"3.8.1.7","compounds":"4-chlorobenzoyl-CoA + H2O = 4-hydroxybenzoyl-CoA + chloride + H(+)"}
{"X":18031,"RHEA_ID":14854,"DIRECTION":"LR","MASTER_ID":14853,"macie":"M0024","metacyc":"3.8.1.7-RXN","compounds":"4-chlorobenzoyl-CoA + H2O => 4-hydroxybenzoyl-CoA + chloride + H(+)"}
{"X":18032,"RHEA_ID":14855,"compounds":"4-hydroxybenzoyl-CoA + chloride + H(+) => 4-chlorobenzoyl-CoA + H2O"}
{"X":18033,"RHEA_ID":24686,"compounds":"H2O + N-formylmethanofuran = formate + methanofuran"}
{"X":18034,"RHEA_ID":14857,"DIRECTION":"UN","MASTER_ID":14857,"ec":"6.3.2.20","compounds":"(indol-3-yl)acetate + ATP + L-lysine = ADP + H(+) + N(6)-[(indole-3-yl)acetyl]-L-lysine + phosphate"}
{"X":18035,"RHEA_ID":14858,"DIRECTION":"LR","MASTER_ID":14857,"metacyc":"INDOLEACETATE--LYSINE-LIGASE-RXN","compounds":"(indol-3-yl)acetate + ATP + L-lysine => ADP + H(+) + N(6)-[(indole-3-yl)acetyl]-L-lysine + phosphate"}
{"X":18036,"RHEA_ID":14859,"compounds":"ADP + H(+) + N(6)-[(indole-3-yl)acetyl]-L-lysine + phosphate => (indol-3-yl)acetate + ATP + L-lysine"}
{"X":18037,"RHEA_ID":24690,"DIRECTION":"UN","MASTER_ID":24690,"ec":"1.1.1.318","compounds":"acetate + eugenol + NADP(+) = coniferyl acetate + NADPH"}
{"X":18038,"RHEA_ID":14861,"DIRECTION":"UN","MASTER_ID":14861,"ec":"1.3.1.15","metacyc":"OROTATE-REDUCTASE-NADPH-RXN","compounds":"(S)-dihydroorotate + NADP(+) = H(+) + NADPH + orotate"}
{"X":18039,"RHEA_ID":14862,"compounds":"(S)-dihydroorotate + NADP(+) => H(+) + NADPH + orotate"}
{"X":18040,"RHEA_ID":14863,"compounds":"H(+) + NADPH + orotate => (S)-dihydroorotate + NADP(+)"}
{"X":18041,"RHEA_ID":24694,"DIRECTION":"UN","MASTER_ID":24694,"ec":"1.1.1.319","compounds":"acetate + NADP(+) + trans-isoeugenol = coniferyl acetate + NADPH"}
{"X":18042,"RHEA_ID":14865,"DIRECTION":"UN","MASTER_ID":14865,"ec":"2.1.1.27","compounds":"S-adenosyl-L-methionine + tyramine = H(+) + N-methyltyramine + S-adenosyl-L-homocysteine"}
{"X":18043,"RHEA_ID":14866,"DIRECTION":"LR","MASTER_ID":14865,"metacyc":"TYRAMINE-N-METHYLTRANSFERASE-RXN","compounds":"S-adenosyl-L-methionine + tyramine => H(+) + N-methyltyramine + S-adenosyl-L-homocysteine"}
{"X":18044,"RHEA_ID":14867,"compounds":"H(+) + N-methyltyramine + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + tyramine"}
{"X":18045,"RHEA_ID":24698,"DIRECTION":"UN","MASTER_ID":24698,"ec":"2.7.8.42","compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A = 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + a 1,2-diacyl-sn-glycerol"}
{"X":18046,"RHEA_ID":14869,"compounds":"an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O = acetate + an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative"}
{"X":18047,"RHEA_ID":14870,"compounds":"an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O => acetate + an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative"}
{"X":18048,"RHEA_ID":14871,"compounds":"acetate + an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative => an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O"}
{"X":18049,"RHEA_ID":14873,"DIRECTION":"UN","MASTER_ID":14873,"ec":"1.1.1.190","compounds":"indole-3-ethanol + NAD(+) = H(+) + indole-3-acetaldehyde + NADH"}
{"X":18050,"RHEA_ID":14874,"compounds":"indole-3-ethanol + NAD(+) => H(+) + indole-3-acetaldehyde + NADH"}
{"X":18051,"RHEA_ID":14875,"DIRECTION":"RL","MASTER_ID":14873,"metacyc":"1.1.1.190-RXN","compounds":"H(+) + indole-3-acetaldehyde + NADH => indole-3-ethanol + NAD(+)"}
{"X":18052,"RHEA_ID":24706,"DIRECTION":"UN","MASTER_ID":24706,"ec":"2.1.2.13","compounds":"(6S)-10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinose = (6S)-5,6,7,8-tetrahydrofolate + H(+) + UDP-4-deoxy-4-formamido-beta-L-arabinose"}
{"X":18053,"RHEA_ID":14877,"DIRECTION":"UN","MASTER_ID":14877,"ec":"2.7.2.11","compounds":"ATP + L-glutamate = ADP + L-glutamyl 5-phosphate"}
{"X":18054,"RHEA_ID":14878,"DIRECTION":"LR","MASTER_ID":14877,"ecocyc":"GLUTKIN-RXN","metacyc":"GLUTKIN-RXN","compounds":"ATP + L-glutamate => ADP + L-glutamyl 5-phosphate"}
{"X":18055,"RHEA_ID":14879,"compounds":"ADP + L-glutamyl 5-phosphate => ATP + L-glutamate"}
{"X":18056,"RHEA_ID":24710,"DIRECTION":"UN","MASTER_ID":24710,"ec":"2.6.1.87","compounds":"2-oxoglutarate + UDP-4-amino-4-deoxy-beta-L-arabinose = L-glutamate + UDP-beta-L-threo-pentopyranos-4-ulose"}
{"X":18057,"RHEA_ID":14881,"DIRECTION":"UN","MASTER_ID":14881,"ec":"1.8.1.11","metacyc":"ASPARAGUSATE-REDUCTASE-NADH-RXN","compounds":"3-mercapto-2-mercaptomethylpropanoate + NAD(+) = asparagusate + H(+) + NADH"}
{"X":18058,"RHEA_ID":14882,"compounds":"3-mercapto-2-mercaptomethylpropanoate + NAD(+) => asparagusate + H(+) + NADH"}
{"X":18059,"RHEA_ID":14883,"compounds":"asparagusate + H(+) + NADH => 3-mercapto-2-mercaptomethylpropanoate + NAD(+)"}
{"X":18060,"RHEA_ID":24722,"DIRECTION":"UN","MASTER_ID":24722,"ec":"1.14.13.225","compounds":"H(+) + L-methionyl(44)-[F-actin] + NADPH + O2 = H2O + L-methionyl(44)-(R)-S-oxide-[F-actin] + NADP(+)"}
{"X":18061,"RHEA_ID":14885,"DIRECTION":"UN","MASTER_ID":14885,"ec":"3.2.2.19","compounds":"H2O + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] = ADP-D-ribose + L-arginyl-[protein]"}
{"X":18062,"RHEA_ID":14886,"DIRECTION":"LR","MASTER_ID":14885,"metacyc":"ADP-RIBOSYLARGININE-HYDROLASE-RXN","compounds":"H2O + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] => ADP-D-ribose + L-arginyl-[protein]"}
{"X":18063,"RHEA_ID":14887,"compounds":"ADP-D-ribose + L-arginyl-[protein] => H2O + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein]"}
{"X":18064,"RHEA_ID":14889,"DIRECTION":"UN","MASTER_ID":14889,"ec":"5.3.3.13","compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate = (5Z,7E,9E,14Z,17Z)-icosapentaenoate"}
{"X":18065,"RHEA_ID":14890,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate => (5Z,7E,9E,14Z,17Z)-icosapentaenoate"}
{"X":18066,"RHEA_ID":14891,"compounds":"(5Z,7E,9E,14Z,17Z)-icosapentaenoate => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate"}
{"X":18067,"RHEA_ID":24730,"DIRECTION":"UN","MASTER_ID":24730,"ec":"4.1.1.24","compounds":"anthranilate + H(+) = aniline + CO2"}
{"X":18068,"RHEA_ID":14893,"DIRECTION":"UN","MASTER_ID":14893,"ec":"5.4.3.5","compounds":"D-ornithine = (2R,4S)-2,4-diaminopentanoate"}
{"X":18069,"RHEA_ID":14894,"compounds":"D-ornithine => (2R,4S)-2,4-diaminopentanoate"}
{"X":18070,"RHEA_ID":14895,"compounds":"(2R,4S)-2,4-diaminopentanoate => D-ornithine"}
{"X":18071,"RHEA_ID":24734,"DIRECTION":"UN","MASTER_ID":24734,"ec":"1.1.99.24","compounds":"2-oxoglutarate + 4-hydroxybutanoate = (R)-2-hydroxyglutarate + succinate semialdehyde"}
{"X":18072,"RHEA_ID":14897,"compounds":"apigenin + 3 H(+) + 2 NADPH + O2 = 2-hydroxy-2,3-dihydrogenistein + H2O + 2 NADP(+)"}
{"X":18073,"RHEA_ID":14898,"DIRECTION":"LR","MASTER_ID":14897,"metacyc":"RXN-7750","compounds":"apigenin + 3 H(+) + 2 NADPH + O2 => 2-hydroxy-2,3-dihydrogenistein + H2O + 2 NADP(+)"}
{"X":18074,"RHEA_ID":14899,"compounds":"2-hydroxy-2,3-dihydrogenistein + H2O + 2 NADP(+) => apigenin + 3 H(+) + 2 NADPH + O2"}
{"X":18075,"RHEA_ID":24738,"compounds":"(6R)-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH"}
{"X":18076,"RHEA_ID":14901,"DIRECTION":"UN","MASTER_ID":14901,"ec":"4.2.3.8","compounds":"all-trans-geranylgeranyl diphosphate = casbene + diphosphate"}
{"X":18077,"RHEA_ID":14902,"DIRECTION":"LR","MASTER_ID":14901,"metacyc":"CASBENE-SYNTHASE-RXN","compounds":"all-trans-geranylgeranyl diphosphate => casbene + diphosphate"}
{"X":18078,"RHEA_ID":14903,"compounds":"casbene + diphosphate => all-trans-geranylgeranyl diphosphate"}
{"X":18079,"RHEA_ID":24742,"compounds":"2-aminobut-2-enoate + H2O = 2-oxobutanoate + NH4(+)"}
{"X":18080,"RHEA_ID":14905,"DIRECTION":"UN","MASTER_ID":14905,"ec":"2.4.2.14","compounds":"5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine"}
{"X":18081,"RHEA_ID":14906,"compounds":"5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate => 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine"}
{"X":18082,"RHEA_ID":14907,"DIRECTION":"RL","MASTER_ID":14905,"ecocyc":"PRPPAMIDOTRANS-RXN","compounds":"5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine => 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate"}
{"X":18083,"RHEA_ID":24746,"compounds":"L-methionine = 2-aminobut-2-enoate + methanethiol"}
{"X":18084,"RHEA_ID":14909,"DIRECTION":"UN","MASTER_ID":14909,"ec":"1.1.1.19","compounds":"L-gulonate + NADP(+) = aldehydo-D-glucuronate + H(+) + NADPH"}
{"X":18085,"RHEA_ID":14910,"compounds":"L-gulonate + NADP(+) => aldehydo-D-glucuronate + H(+) + NADPH"}
{"X":18086,"RHEA_ID":14911,"DIRECTION":"RL","MASTER_ID":14909,"metacyc":"GLUCURONATE-REDUCTASE-RXN","compounds":"aldehydo-D-glucuronate + H(+) + NADPH => L-gulonate + NADP(+)"}
{"X":18087,"RHEA_ID":24752,"DIRECTION":"UN","MASTER_ID":24752,"ec":"1.3.7.12","compounds":"2 oxidized [2Fe-2S]-[ferredoxin] + primary fluorescent chlorophyll catabolite = 3 H(+) + red chlorophyll catabolite + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":18088,"RHEA_ID":14913,"DIRECTION":"UN","MASTER_ID":14913,"ec":"2.7.1.114","metacyc":"AMP--THYMIDINE-KINASE-RXN","compounds":"AMP + thymidine = adenosine + dTMP"}
{"X":18089,"RHEA_ID":14914,"compounds":"AMP + thymidine => adenosine + dTMP"}
{"X":18090,"RHEA_ID":14915,"compounds":"adenosine + dTMP => AMP + thymidine"}
{"X":18091,"RHEA_ID":24756,"compounds":"H(+) + NADPH + O2 + pheophorbide a = NADP(+) + red chlorophyll catabolite"}
{"X":18092,"RHEA_ID":14917,"DIRECTION":"UN","MASTER_ID":14917,"ec":"1.14.14.154","compounds":"3 O2 + obtusifoliol + 3 reduced [NADPH--hemoprotein reductase] = 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}
{"X":18093,"RHEA_ID":14918,"DIRECTION":"LR","MASTER_ID":14917,"metacyc":"1.14.13.70-RXN","compounds":"3 O2 + obtusifoliol + 3 reduced [NADPH--hemoprotein reductase] => 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}
{"X":18094,"RHEA_ID":14919,"compounds":"4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 3 O2 + obtusifoliol + 3 reduced [NADPH--hemoprotein reductase]"}
{"X":18095,"RHEA_ID":24760,"DIRECTION":"UN","MASTER_ID":24760,"ec":"4.3.1.22","metacyc":"4.3.1.22-RXN","compounds":"H(+) + L-dopa + NADH = 3-(3,4-dihydroxyphenyl)propanoate + NAD(+) + NH4(+)"}
{"X":18096,"RHEA_ID":14921,"DIRECTION":"UN","MASTER_ID":14921,"ec":"2.4.1.121","compounds":"(indol-3-yl)acetate + UDP-alpha-D-glucose = 1-O-(indol-3-ylacetyl)-beta-D-glucose + UDP"}
{"X":18097,"RHEA_ID":14922,"DIRECTION":"LR","MASTER_ID":14921,"metacyc":"2.4.1.121-RXN","compounds":"(indol-3-yl)acetate + UDP-alpha-D-glucose => 1-O-(indol-3-ylacetyl)-beta-D-glucose + UDP"}
{"X":18098,"RHEA_ID":14923,"compounds":"1-O-(indol-3-ylacetyl)-beta-D-glucose + UDP => (indol-3-yl)acetate + UDP-alpha-D-glucose"}
{"X":18099,"RHEA_ID":24764,"DIRECTION":"UN","MASTER_ID":24764,"ec":"5.1.3.23","compounds":"UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate = UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate"}
{"X":18100,"RHEA_ID":14925,"DIRECTION":"UN","MASTER_ID":14925,"ec":"1.1.1.224","compounds":"D-mannitol 1-phosphate + NADP(+) = D-mannose 6-phosphate + H(+) + NADPH"}
{"X":18101,"RHEA_ID":14926,"compounds":"D-mannitol 1-phosphate + NADP(+) => D-mannose 6-phosphate + H(+) + NADPH"}
{"X":18102,"RHEA_ID":14927,"DIRECTION":"RL","MASTER_ID":14925,"metacyc":"MANNOSE-6-PHOSPHATE-6-REDUCTASE-RXN","compounds":"D-mannose 6-phosphate + H(+) + NADPH => D-mannitol 1-phosphate + NADP(+)"}
{"X":18103,"RHEA_ID":24768,"DIRECTION":"UN","MASTER_ID":24768,"ec":"1.1.1.294","compounds":"7(1)-hydroxychlorophyllide a + NAD(+) = chlorophyllide b + H(+) + NADH"}
{"X":18104,"RHEA_ID":14929,"DIRECTION":"UN","MASTER_ID":14929,"ec":"1.1.1.51","compounds":"NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH"}
{"X":18105,"RHEA_ID":14929,"DIRECTION":"UN","MASTER_ID":14929,"ec":"1.1.1.239","compounds":"NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH"}
{"X":18106,"RHEA_ID":14930,"DIRECTION":"LR","MASTER_ID":14929,"metacyc":"1.1.1.51-RXN","compounds":"NAD(+) + testosterone => androst-4-ene-3,17-dione + H(+) + NADH"}
{"X":18107,"RHEA_ID":14931,"compounds":"androst-4-ene-3,17-dione + H(+) + NADH => NAD(+) + testosterone"}
{"X":18108,"RHEA_ID":24773,"compounds":"7(1)-hydroxychlorophyllide a + NADP(+) => chlorophyllide b + H(+) + NADPH"}
{"X":18109,"RHEA_ID":14933,"compounds":"H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein] = N(6)-(D-erythrulosyl)-L-lysyl-[protein] + phosphate"}
{"X":18110,"RHEA_ID":14934,"compounds":"H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein] => N(6)-(D-erythrulosyl)-L-lysyl-[protein] + phosphate"}
{"X":18111,"RHEA_ID":14935,"compounds":"N(6)-(D-erythrulosyl)-L-lysyl-[protein] + phosphate => H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein]"}
{"X":18112,"RHEA_ID":14936,"compounds":"H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein] <=> N(6)-(D-erythrulosyl)-L-lysyl-[protein] + phosphate"}
{"X":18113,"RHEA_ID":14937,"compounds":"all-trans-antheraxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = all-trans-violaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":18114,"RHEA_ID":14938,"DIRECTION":"LR","MASTER_ID":14937,"metacyc":"RXN-7979","compounds":"all-trans-antheraxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => all-trans-violaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":18115,"RHEA_ID":14939,"compounds":"all-trans-violaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => all-trans-antheraxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":18116,"RHEA_ID":14945,"DIRECTION":"UN","MASTER_ID":14945,"ec":"2.4.1.46","compounds":"a 1,2-diacyl-sn-glycerol + UDP-alpha-D-galactose = a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) + UDP"}
{"X":18117,"RHEA_ID":14946,"DIRECTION":"LR","MASTER_ID":14945,"metacyc":"2.4.1.46-RXN","compounds":"a 1,2-diacyl-sn-glycerol + UDP-alpha-D-galactose => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) + UDP"}
{"X":18118,"RHEA_ID":14947,"compounds":"a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) + UDP => a 1,2-diacyl-sn-glycerol + UDP-alpha-D-galactose"}
{"X":18119,"RHEA_ID":24786,"DIRECTION":"LR","MASTER_ID":24785,"ecocyc":"MHPHYDROXY-RXN","metacyc":"MHPHYDROXY-RXN","compounds":"3-(3-hydroxyphenyl)propanoate + H(+) + NADH + O2 => 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+)"}
{"X":18120,"RHEA_ID":14949,"DIRECTION":"UN","MASTER_ID":14949,"ec":"1.3.99.19","metacyc":"1.3.99.19-RXN","compounds":"A + H2O + quinoline-4-carboxylate = 2-oxo-1,2-dihydroquinoline-4-carboxylate + AH2"}
{"X":18121,"RHEA_ID":14950,"compounds":"A + H2O + quinoline-4-carboxylate => 2-oxo-1,2-dihydroquinoline-4-carboxylate + AH2"}
{"X":18122,"RHEA_ID":14951,"compounds":"2-oxo-1,2-dihydroquinoline-4-carboxylate + AH2 => A + H2O + quinoline-4-carboxylate"}
{"X":18123,"RHEA_ID":24790,"compounds":"(2E,4Z)-2-hydroxy-6-oxononadienedioate + H2O => (2E)-2-hydroxypenta-2,4-dienoate + H(+) + succinate"}
{"X":18124,"RHEA_ID":14953,"compounds":"H(+) + NADPH + O2 + tetradecanoyl-CoA = (11Z)-tetradecenoyl-CoA + 2 H2O + NADP(+)"}
{"X":18125,"RHEA_ID":14954,"compounds":"H(+) + NADPH + O2 + tetradecanoyl-CoA => (11Z)-tetradecenoyl-CoA + 2 H2O + NADP(+)"}
{"X":18126,"RHEA_ID":14955,"compounds":"(11Z)-tetradecenoyl-CoA + 2 H2O + NADP(+) => H(+) + NADPH + O2 + tetradecanoyl-CoA"}
{"X":18127,"RHEA_ID":24794,"compounds":"5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate"}
{"X":18128,"RHEA_ID":14957,"compounds":"H(+) + NADH + O2 + tetradecanoyl-CoA = (11Z)-tetradecenoyl-CoA + 2 H2O + NAD(+)"}
{"X":18129,"RHEA_ID":14958,"compounds":"H(+) + NADH + O2 + tetradecanoyl-CoA => (11Z)-tetradecenoyl-CoA + 2 H2O + NAD(+)"}
{"X":18130,"RHEA_ID":14959,"compounds":"(11Z)-tetradecenoyl-CoA + 2 H2O + NAD(+) => H(+) + NADH + O2 + tetradecanoyl-CoA"}
{"X":18131,"RHEA_ID":24798,"DIRECTION":"LR","MASTER_ID":24797,"metacyc":"RXN-4821","compounds":"(S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O => (S)-2-amino-6-oxoheptanedioate"}
{"X":18132,"RHEA_ID":14961,"DIRECTION":"UN","MASTER_ID":14961,"ec":"3.1.2.12","compounds":"H2O + S-formylglutathione = formate + glutathione + H(+)"}
{"X":18133,"RHEA_ID":14962,"DIRECTION":"LR","MASTER_ID":14961,"ecocyc":"S-FORMYLGLUTATHIONE-HYDROLASE-RXN","metacyc":"S-FORMYLGLUTATHIONE-HYDROLASE-RXN","reactome":"R-HSA-5693724.1","compounds":"H2O + S-formylglutathione => formate + glutathione + H(+)"}
{"X":18134,"RHEA_ID":14963,"compounds":"formate + glutathione + H(+) => H2O + S-formylglutathione"}
{"X":18135,"RHEA_ID":24802,"compounds":"2-oxoglutarate + L-isoleucine => (S)-3-methyl-2-oxopentanoate + L-glutamate"}
{"X":18136,"RHEA_ID":14965,"DIRECTION":"UN","MASTER_ID":14965,"ec":"3.6.1.7","compounds":"an acyl phosphate + H2O = a carboxylate + H(+) + phosphate"}
{"X":18137,"RHEA_ID":14966,"DIRECTION":"LR","MASTER_ID":14965,"ecocyc":"ACYLPHOSPHATASE-RXN","metacyc":"ACYLPHOSPHATASE-RXN","compounds":"an acyl phosphate + H2O => a carboxylate + H(+) + phosphate"}
{"X":18138,"RHEA_ID":14967,"compounds":"a carboxylate + H(+) + phosphate => an acyl phosphate + H2O"}
{"X":18139,"RHEA_ID":14969,"DIRECTION":"UN","MASTER_ID":14969,"ec":"2.1.1.144","compounds":"S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine"}
{"X":18140,"RHEA_ID":14970,"DIRECTION":"LR","MASTER_ID":14969,"ecocyc":"RXN0-2441","metacyc":"RXN0-2441","compounds":"S-adenosyl-L-methionine + trans-aconitate => (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine"}
{"X":18141,"RHEA_ID":14971,"compounds":"(E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + trans-aconitate"}
{"X":18142,"RHEA_ID":24810,"DIRECTION":"LR","MASTER_ID":24809,"ecocyc":"DIHYDROXYISOVALDEHYDRAT-RXN","metacyc":"DIHYDROXYISOVALDEHYDRAT-RXN","compounds":"(2R)-2,3-dihydroxy-3-methylbutanoate => 3-methyl-2-oxobutanoate + H2O"}
{"X":18143,"RHEA_ID":14973,"DIRECTION":"UN","MASTER_ID":14973,"ec":"5.1.1.13","compounds":"L-aspartate = D-aspartate"}
{"X":18144,"RHEA_ID":14974,"compounds":"L-aspartate => D-aspartate"}
{"X":18145,"RHEA_ID":14975,"compounds":"D-aspartate => L-aspartate"}
{"X":18146,"RHEA_ID":24814,"compounds":"2-oxoglutarate + L-valine => 3-methyl-2-oxobutanoate + L-glutamate"}
{"X":18147,"RHEA_ID":14977,"DIRECTION":"UN","MASTER_ID":14977,"ec":"5.5.1.5","compounds":"3-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 3-carboxy-cis,cis-muconate"}
{"X":18148,"RHEA_ID":14978,"compounds":"3-carboxy-2,5-dihydro-5-oxofuran-2-acetate => 3-carboxy-cis,cis-muconate"}
{"X":18149,"RHEA_ID":14979,"compounds":"3-carboxy-cis,cis-muconate => 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate"}
{"X":18150,"RHEA_ID":24826,"compounds":"dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":18151,"RHEA_ID":14981,"DIRECTION":"UN","MASTER_ID":14981,"ec":"1.1.1.51","compounds":"NADP(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADPH"}
{"X":18152,"RHEA_ID":14981,"DIRECTION":"UN","MASTER_ID":14981,"ec":"1.1.1.64","compounds":"NADP(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADPH"}
{"X":18153,"RHEA_ID":14982,"DIRECTION":"LR","MASTER_ID":14981,"metacyc":"1.1.1.51-RXN","compounds":"NADP(+) + testosterone => androst-4-ene-3,17-dione + H(+) + NADPH"}
{"X":18154,"RHEA_ID":14983,"DIRECTION":"RL","MASTER_ID":14981,"metacyc":"1.1.1.64-RXN","reactome":"R-HSA-193064.2","compounds":"androst-4-ene-3,17-dione + H(+) + NADPH => NADP(+) + testosterone"}
{"X":18155,"RHEA_ID":24831,"compounds":"ADP + H(+) + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + phosphate => ATP + formate + N(1)-(5-phospho-D-ribosyl)glycinamide"}
{"X":18156,"RHEA_ID":14985,"DIRECTION":"UN","MASTER_ID":14985,"ec":"1.13.11.40","compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate"}
{"X":18157,"RHEA_ID":14986,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate"}
{"X":18158,"RHEA_ID":14987,"compounds":"(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2"}
{"X":18159,"RHEA_ID":24838,"compounds":"5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + ADP + phosphate => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + ATP + formate"}
{"X":18160,"RHEA_ID":14993,"DIRECTION":"UN","MASTER_ID":14993,"ec":"2.3.1.85","compounds":"acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+)"}
{"X":18161,"RHEA_ID":14994,"DIRECTION":"LR","MASTER_ID":14993,"metacyc":"FATTY-ACID-SYNTHASE-RXN","compounds":"acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH => a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+)"}
{"X":18162,"RHEA_ID":14995,"compounds":"a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+) => acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH"}
{"X":18163,"RHEA_ID":24842,"compounds":"4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine"}
{"X":18164,"RHEA_ID":14997,"DIRECTION":"UN","MASTER_ID":14997,"ec":"3.1.1.46","compounds":"deoxylimonoate + H2O = deoxylimononate D-ring-lactone + H(+)"}
{"X":18165,"RHEA_ID":14998,"DIRECTION":"LR","MASTER_ID":14997,"metacyc":"DEOXYLIMONATE-A-RING-LACTONASE-RXN","compounds":"deoxylimonoate + H2O => deoxylimononate D-ring-lactone + H(+)"}
{"X":18166,"RHEA_ID":14999,"compounds":"deoxylimononate D-ring-lactone + H(+) => deoxylimonoate + H2O"}
{"X":18167,"RHEA_ID":24846,"compounds":"2 isomaltose => cyclobis-(1->3)-alpha-isomaltosyl + 2 H2O"}
{"X":18168,"RHEA_ID":15001,"DIRECTION":"UN","MASTER_ID":15001,"ec":"1.1.1.123","metacyc":"SORBOSE-5-DEHYDROGENASE-NADP%2b-RXN","compounds":"keto-L-sorbose + NADP(+) = 5-dehydro-D-fructose + H(+) + NADPH"}
{"X":18169,"RHEA_ID":15002,"compounds":"keto-L-sorbose + NADP(+) => 5-dehydro-D-fructose + H(+) + NADPH"}
{"X":18170,"RHEA_ID":15003,"compounds":"5-dehydro-D-fructose + H(+) + NADPH => keto-L-sorbose + NADP(+)"}
{"X":18171,"RHEA_ID":24850,"compounds":"3,4-dihydroxybenzoate + H2O => 3-dehydroshikimate"}
{"X":18172,"RHEA_ID":15005,"DIRECTION":"UN","MASTER_ID":15005,"ec":"1.14.11.13","compounds":"2-oxoglutarate + gibberellin A1 + O2 = CO2 + gibberellin A8 + succinate"}
{"X":18173,"RHEA_ID":15006,"DIRECTION":"LR","MASTER_ID":15005,"metacyc":"RXN-115","compounds":"2-oxoglutarate + gibberellin A1 + O2 => CO2 + gibberellin A8 + succinate"}
{"X":18174,"RHEA_ID":15007,"compounds":"CO2 + gibberellin A8 + succinate => 2-oxoglutarate + gibberellin A1 + O2"}
{"X":18175,"RHEA_ID":24863,"compounds":"H(+) + pelargonidin 3-O-rutinoside 5-O-beta-D-glucoside + UDP => pelargonidin 3-O-rutinoside + UDP-alpha-D-glucose"}
{"X":18176,"RHEA_ID":15009,"DIRECTION":"UN","MASTER_ID":15009,"ec":"1.5.1.3","compounds":"(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH"}
{"X":18177,"RHEA_ID":15010,"compounds":"(6S)-5,6,7,8-tetrahydrofolate + NADP(+) => 7,8-dihydrofolate + H(+) + NADPH"}
{"X":18178,"RHEA_ID":15011,"DIRECTION":"RL","MASTER_ID":15009,"ecocyc":"DIHYDROFOLATEREDUCT-RXN","macie":"M0112","metacyc":"DIHYDROFOLATEREDUCT-RXN","reactome":"R-HSA-197972.1","compounds":"7,8-dihydrofolate + H(+) + NADPH => (6S)-5,6,7,8-tetrahydrofolate + NADP(+)"}
{"X":18179,"RHEA_ID":24867,"compounds":"4-O-deacetyl-16-O-demethylvindoline + CO2 + succinate => (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + 2-oxoglutarate + O2"}
{"X":18180,"RHEA_ID":15013,"DIRECTION":"UN","MASTER_ID":15013,"ec":"4.3.3.2","compounds":"3alpha(S)-strictosidine + H2O = secologanin + tryptamine"}
{"X":18181,"RHEA_ID":15014,"compounds":"3alpha(S)-strictosidine + H2O => secologanin + tryptamine"}
{"X":18182,"RHEA_ID":15015,"DIRECTION":"RL","MASTER_ID":15013,"metacyc":"STRICTOSIDINE-SYNTHASE-RXN","compounds":"secologanin + tryptamine => 3alpha(S)-strictosidine + H2O"}
{"X":18183,"RHEA_ID":24871,"compounds":"5-deoxy-alpha-D-ribose 1-phosphate + adenine => 5'-deoxyadenosine + phosphate"}
{"X":18184,"RHEA_ID":15017,"DIRECTION":"UN","MASTER_ID":15017,"ec":"3.1.3.1","compounds":"a phosphate monoester + H2O = an alcohol + phosphate"}
{"X":18185,"RHEA_ID":15017,"DIRECTION":"UN","MASTER_ID":15017,"ec":"3.1.3.2","compounds":"a phosphate monoester + H2O = an alcohol + phosphate"}
{"X":18186,"RHEA_ID":15018,"DIRECTION":"LR","MASTER_ID":15017,"ecocyc":"ACID-PHOSPHATASE-RXN","metacyc":"ACID-PHOSPHATASE-RXN","compounds":"a phosphate monoester + H2O => an alcohol + phosphate"}
{"X":18187,"RHEA_ID":15018,"DIRECTION":"LR","MASTER_ID":15017,"ecocyc":"ACID-PHOSPHATASE-RXN","metacyc":"ALKAPHOSPHA-RXN","compounds":"a phosphate monoester + H2O => an alcohol + phosphate"}
{"X":18188,"RHEA_ID":15018,"DIRECTION":"LR","MASTER_ID":15017,"ecocyc":"ALKAPHOSPHA-RXN","metacyc":"ACID-PHOSPHATASE-RXN","compounds":"a phosphate monoester + H2O => an alcohol + phosphate"}
{"X":18189,"RHEA_ID":15018,"DIRECTION":"LR","MASTER_ID":15017,"ecocyc":"ALKAPHOSPHA-RXN","metacyc":"ALKAPHOSPHA-RXN","compounds":"a phosphate monoester + H2O => an alcohol + phosphate"}
{"X":18190,"RHEA_ID":15019,"compounds":"an alcohol + phosphate => a phosphate monoester + H2O"}
{"X":18191,"RHEA_ID":15021,"DIRECTION":"UN","MASTER_ID":15021,"ec":"2.3.1.99","metacyc":"2.3.1.99-RXN","compounds":"(E)-feruloyl-CoA + L-quinate = 4-O-feruloyl-D-quinate + CoA"}
{"X":18192,"RHEA_ID":15022,"compounds":"(E)-feruloyl-CoA + L-quinate => 4-O-feruloyl-D-quinate + CoA"}
{"X":18193,"RHEA_ID":15023,"compounds":"4-O-feruloyl-D-quinate + CoA => (E)-feruloyl-CoA + L-quinate"}
{"X":18194,"RHEA_ID":24884,"compounds":"H(+) + L-glutamate + NADPH => (S)-1-pyrroline-5-carboxylate + 2 H2O + NADP(+)"}
{"X":18195,"RHEA_ID":15025,"DIRECTION":"UN","MASTER_ID":15025,"ec":"2.1.1.158","compounds":"S-adenosyl-L-methionine + xanthosine = 7-methylxanthosine + S-adenosyl-L-homocysteine"}
{"X":18196,"RHEA_ID":15026,"DIRECTION":"LR","MASTER_ID":15025,"metacyc":"RXN-7596","compounds":"S-adenosyl-L-methionine + xanthosine => 7-methylxanthosine + S-adenosyl-L-homocysteine"}
{"X":18197,"RHEA_ID":15027,"compounds":"7-methylxanthosine + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + xanthosine"}
{"X":18198,"RHEA_ID":24888,"compounds":"D-glutamate + H(+) + NADH => (R)-1-pyrroline-5-carboxylate + 2 H2O + NAD(+)"}
{"X":18199,"RHEA_ID":15029,"DIRECTION":"UN","MASTER_ID":15029,"ec":"1.1.1.255","compounds":"D-mannitol + NAD(+) = D-mannose + H(+) + NADH"}
{"X":18200,"RHEA_ID":15030,"compounds":"D-mannitol + NAD(+) => D-mannose + H(+) + NADH"}
{"X":18201,"RHEA_ID":15031,"compounds":"D-mannose + H(+) + NADH => D-mannitol + NAD(+)"}
{"X":18202,"RHEA_ID":24892,"compounds":"4-hydroxy-L-glutamate + H(+) + NADH => 1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NAD(+)"}
{"X":18203,"RHEA_ID":15033,"DIRECTION":"UN","MASTER_ID":15033,"ec":"1.1.3.12","compounds":"O2 + pyridoxine = H2O2 + pyridoxal"}
{"X":18204,"RHEA_ID":15034,"DIRECTION":"LR","MASTER_ID":15033,"metacyc":"PYRIDOXINE-4-OXIDASE-RXN","compounds":"O2 + pyridoxine => H2O2 + pyridoxal"}
{"X":18205,"RHEA_ID":15035,"compounds":"H2O2 + pyridoxal => O2 + pyridoxine"}
{"X":18206,"RHEA_ID":24896,"compounds":"isopimpinellin + S-adenosyl-L-homocysteine => 5-hydroxyxanthotoxin + S-adenosyl-L-methionine"}
{"X":18207,"RHEA_ID":15037,"DIRECTION":"UN","MASTER_ID":15037,"ec":"2.1.1.53","compounds":"putrescine + S-adenosyl-L-methionine = H(+) + N-methylputrescine + S-adenosyl-L-homocysteine"}
{"X":18208,"RHEA_ID":15038,"DIRECTION":"LR","MASTER_ID":15037,"metacyc":"PUTRESCINE-N-METHYLTRANSFERASE-RXN","compounds":"putrescine + S-adenosyl-L-methionine => H(+) + N-methylputrescine + S-adenosyl-L-homocysteine"}
{"X":18209,"RHEA_ID":15039,"compounds":"H(+) + N-methylputrescine + S-adenosyl-L-homocysteine => putrescine + S-adenosyl-L-methionine"}
{"X":18210,"RHEA_ID":24900,"compounds":"cyclic di-3',5'-guanylate + 2 diphosphate => 2 GTP"}
{"X":18211,"RHEA_ID":15041,"DIRECTION":"UN","MASTER_ID":15041,"ec":"3.2.1.134","compounds":"bis-D-fructose 2',1:2,1'-dianhydride + H2O = inulobiose"}
{"X":18212,"RHEA_ID":15042,"DIRECTION":"LR","MASTER_ID":15041,"metacyc":"DIFRUCTOSE-ANHYDRIDE-SYNTHASE-RXN","compounds":"bis-D-fructose 2',1:2,1'-dianhydride + H2O => inulobiose"}
{"X":18213,"RHEA_ID":15043,"compounds":"inulobiose => bis-D-fructose 2',1:2,1'-dianhydride + H2O"}
{"X":18214,"RHEA_ID":24904,"compounds":"5'-phosphoguanylyl(3'->5')guanosine + H(+) => cyclic di-3',5'-guanylate + H2O"}
{"X":18215,"RHEA_ID":15045,"DIRECTION":"UN","MASTER_ID":15045,"ec":"1.8.1.4","compounds":"(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH"}
{"X":18216,"RHEA_ID":15046,"DIRECTION":"LR","MASTER_ID":15045,"ecocyc":"1.8.1.4-RXN","metacyc":"1.8.1.4-RXN","compounds":"(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) => (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH"}
{"X":18217,"RHEA_ID":15047,"compounds":"(R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH => (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+)"}
{"X":18218,"RHEA_ID":15049,"DIRECTION":"UN","MASTER_ID":15049,"ec":"3.2.1.42","compounds":"GDP-alpha-D-glucose + H2O = D-glucose + GDP + H(+)"}
{"X":18219,"RHEA_ID":15050,"DIRECTION":"LR","MASTER_ID":15049,"ecocyc":"GDP-GLUCOSIDASE-RXN","metacyc":"GDP-GLUCOSIDASE-RXN","compounds":"GDP-alpha-D-glucose + H2O => D-glucose + GDP + H(+)"}
{"X":18220,"RHEA_ID":15051,"compounds":"D-glucose + GDP + H(+) => GDP-alpha-D-glucose + H2O"}
{"X":18221,"RHEA_ID":45435,"compounds":"H2O + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> H(+) + N-(9Z-octadecenoyl) ethanolamine + sn-glycerol 3-phosphate"}
{"X":18222,"RHEA_ID":15053,"DIRECTION":"UN","MASTER_ID":15053,"ec":"2.1.2.2","compounds":"(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide"}
{"X":18223,"RHEA_ID":15054,"DIRECTION":"LR","MASTER_ID":15053,"reactome":"R-HSA-73813.2","compounds":"(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-D-ribosyl)glycinamide => (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide"}
{"X":18224,"RHEA_ID":15055,"compounds":"(6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide => (6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-D-ribosyl)glycinamide"}
{"X":18225,"RHEA_ID":24922,"compounds":"L-homoserine <=> 2-aminobut-2-enoate + H2O"}
{"X":18226,"RHEA_ID":15057,"DIRECTION":"UN","MASTER_ID":15057,"ec":"3.1.2.14","compounds":"(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + H(+) + holo-[ACP]"}
{"X":18227,"RHEA_ID":15058,"DIRECTION":"LR","MASTER_ID":15057,"metacyc":"3.1.2.14-RXN","compounds":"(9Z)-octadecenoyl-[ACP] + H2O => (9Z)-octadecenoate + H(+) + holo-[ACP]"}
{"X":18228,"RHEA_ID":15059,"compounds":"(9Z)-octadecenoate + H(+) + holo-[ACP] => (9Z)-octadecenoyl-[ACP] + H2O"}
{"X":18229,"RHEA_ID":15061,"DIRECTION":"UN","MASTER_ID":15061,"ec":"1.16.1.7","compounds":"2 a Fe(II)-siderophore + H(+) + NAD(+) = 2 a Fe(III)-siderophore + NADH"}
{"X":18230,"RHEA_ID":15061,"DIRECTION":"UN","MASTER_ID":15061,"ec":"1.16.1.10","compounds":"2 a Fe(II)-siderophore + H(+) + NAD(+) = 2 a Fe(III)-siderophore + NADH"}
{"X":18231,"RHEA_ID":15062,"compounds":"2 a Fe(II)-siderophore + H(+) + NAD(+) => 2 a Fe(III)-siderophore + NADH"}
{"X":18232,"RHEA_ID":15063,"DIRECTION":"RL","MASTER_ID":15061,"metacyc":"FERRIC-CHELATE-REDUCTASE-RXN","compounds":"2 a Fe(III)-siderophore + NADH => 2 a Fe(II)-siderophore + H(+) + NAD(+)"}
{"X":18233,"RHEA_ID":15064,"compounds":"2 a Fe(II)-siderophore + H(+) + NAD(+) <=> 2 a Fe(III)-siderophore + NADH"}
{"X":18234,"RHEA_ID":15065,"DIRECTION":"UN","MASTER_ID":15065,"ec":"3.5.1.40","metacyc":"ACYLAGMATINE-AMIDASE-RXN","compounds":"H2O + N(4)-benzoylagmatine = agmatine + benzoate"}
{"X":18235,"RHEA_ID":15066,"compounds":"H2O + N(4)-benzoylagmatine => agmatine + benzoate"}
{"X":18236,"RHEA_ID":15067,"compounds":"agmatine + benzoate => H2O + N(4)-benzoylagmatine"}
{"X":18237,"RHEA_ID":15069,"DIRECTION":"UN","MASTER_ID":15069,"ec":"4.2.1.165","compounds":"3-devinyl-3-(1-hydroxyethyl)chlorophyllide a = chlorophyllide a + H2O"}
{"X":18238,"RHEA_ID":15070,"compounds":"3-devinyl-3-(1-hydroxyethyl)chlorophyllide a => chlorophyllide a + H2O"}
{"X":18239,"RHEA_ID":15071,"DIRECTION":"RL","MASTER_ID":15069,"metacyc":"RXN-8785","compounds":"chlorophyllide a + H2O => 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a"}
{"X":18240,"RHEA_ID":15073,"DIRECTION":"UN","MASTER_ID":15073,"ec":"3.2.1.56","compounds":"3-D-glucuronosyl-N(2),6-disulfo-beta-D-glucosamine + H2O = D-glucuronate + N(2),6-disulfo-D-glucosamine"}
{"X":18241,"RHEA_ID":15074,"DIRECTION":"LR","MASTER_ID":15073,"metacyc":"RXN-16484","compounds":"3-D-glucuronosyl-N(2),6-disulfo-beta-D-glucosamine + H2O => D-glucuronate + N(2),6-disulfo-D-glucosamine"}
{"X":18242,"RHEA_ID":15075,"compounds":"D-glucuronate + N(2),6-disulfo-D-glucosamine => 3-D-glucuronosyl-N(2),6-disulfo-beta-D-glucosamine + H2O"}
{"X":18243,"RHEA_ID":24942,"compounds":"(R)-1-pyrroline-5-carboxylate + 2 H2O + NADP(+) <=> D-glutamate + H(+) + NADPH"}
{"X":18244,"RHEA_ID":15077,"DIRECTION":"UN","MASTER_ID":15077,"ec":"4.1.1.30","compounds":"H(+) + N-[(R)-pantothenoyl]-L-cysteine = (R)-pantetheine + CO2"}
{"X":18245,"RHEA_ID":15078,"DIRECTION":"LR","MASTER_ID":15077,"metacyc":"PANTOTHENOYLCYSTEINE-DECARBOXYLASE-RXN","compounds":"H(+) + N-[(R)-pantothenoyl]-L-cysteine => (R)-pantetheine + CO2"}
{"X":18246,"RHEA_ID":15079,"compounds":"(R)-pantetheine + CO2 => H(+) + N-[(R)-pantothenoyl]-L-cysteine"}
{"X":18247,"RHEA_ID":24946,"compounds":"1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NADP(+) <=> 4-hydroxy-L-glutamate + H(+) + NADPH"}
{"X":18248,"RHEA_ID":15081,"DIRECTION":"UN","MASTER_ID":15081,"ec":"6.2.1.13","compounds":"acetate + ATP + CoA = acetyl-CoA + ADP + phosphate"}
{"X":18249,"RHEA_ID":15082,"compounds":"acetate + ATP + CoA => acetyl-CoA + ADP + phosphate"}
{"X":18250,"RHEA_ID":15083,"compounds":"acetyl-CoA + ADP + phosphate => acetate + ATP + CoA"}
{"X":18251,"RHEA_ID":24951,"DIRECTION":"BI","MASTER_ID":24948,"metacyc":"RXN-14051","compounds":"3-hydroxy-3-methylglutarate + malonyl-CoA <=> (3S)-hydroxy-3-methylglutaryl-CoA + malonate"}
{"X":18252,"RHEA_ID":15085,"DIRECTION":"UN","MASTER_ID":15085,"ec":"3.2.1.49","compounds":"an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O = an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + N-acetyl-D-galactosamine"}
{"X":18253,"RHEA_ID":15086,"compounds":"an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O => an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + N-acetyl-D-galactosamine"}
{"X":18254,"RHEA_ID":15087,"compounds":"an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + N-acetyl-D-galactosamine => an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O"}
{"X":18255,"RHEA_ID":15088,"compounds":"an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O <=> an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + N-acetyl-D-galactosamine"}
{"X":18256,"RHEA_ID":15089,"DIRECTION":"UN","MASTER_ID":15089,"ec":"1.1.99.6","compounds":"(R)-lactate + A = AH2 + pyruvate"}
{"X":18257,"RHEA_ID":15090,"compounds":"(R)-lactate + A => AH2 + pyruvate"}
{"X":18258,"RHEA_ID":15091,"compounds":"AH2 + pyruvate => (R)-lactate + A"}
{"X":18259,"RHEA_ID":15093,"DIRECTION":"UN","MASTER_ID":15093,"ec":"2.6.1.5","compounds":"2-oxoglutarate + L-tyrosine = 3-(4-hydroxyphenyl)pyruvate + L-glutamate"}
{"X":18260,"RHEA_ID":15093,"DIRECTION":"UN","MASTER_ID":15093,"ec":"2.6.1.57","compounds":"2-oxoglutarate + L-tyrosine = 3-(4-hydroxyphenyl)pyruvate + L-glutamate"}
{"X":18261,"RHEA_ID":15094,"DIRECTION":"LR","MASTER_ID":15093,"reactome":"R-HSA-71155.2","compounds":"2-oxoglutarate + L-tyrosine => 3-(4-hydroxyphenyl)pyruvate + L-glutamate"}
{"X":18262,"RHEA_ID":15095,"DIRECTION":"RL","MASTER_ID":15093,"reactome":"R-HSA-517444.2","compounds":"3-(4-hydroxyphenyl)pyruvate + L-glutamate => 2-oxoglutarate + L-tyrosine"}
{"X":18263,"RHEA_ID":24964,"DIRECTION":"UN","MASTER_ID":24964,"ec":"1.14.15.16","compounds":"calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = calcitetrol + H2O + 2 oxidized [adrenodoxin]"}
{"X":18264,"RHEA_ID":24965,"DIRECTION":"LR","MASTER_ID":24964,"metacyc":"RXN-9830","compounds":"calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => calcitetrol + H2O + 2 oxidized [adrenodoxin]"}
{"X":18265,"RHEA_ID":15097,"DIRECTION":"UN","MASTER_ID":15097,"ec":"2.1.2.5","compounds":"5-formimidoyltetrahydrofolate + L-glutamate = (6S)-5,6,7,8-tetrahydrofolate + N-formimidoyl-L-glutamate"}
{"X":18266,"RHEA_ID":15098,"compounds":"5-formimidoyltetrahydrofolate + L-glutamate => (6S)-5,6,7,8-tetrahydrofolate + N-formimidoyl-L-glutamate"}
{"X":18267,"RHEA_ID":15099,"DIRECTION":"RL","MASTER_ID":15097,"metacyc":"GLUTAMATE-FORMIMINOTRANSFERASE-RXN","reactome":"R-HSA-70920.3","compounds":"(6S)-5,6,7,8-tetrahydrofolate + N-formimidoyl-L-glutamate => 5-formimidoyltetrahydrofolate + L-glutamate"}
{"X":18268,"RHEA_ID":24969,"DIRECTION":"LR","MASTER_ID":24968,"metacyc":"RXN-12069","compounds":"calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => H2O + 2 oxidized [adrenodoxin] + secalciferol"}
{"X":18269,"RHEA_ID":15101,"DIRECTION":"UN","MASTER_ID":15101,"ec":"4.1.1.20","compounds":"H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine"}
{"X":18270,"RHEA_ID":15102,"DIRECTION":"LR","MASTER_ID":15101,"ecocyc":"DIAMINOPIMDECARB-RXN","metacyc":"DIAMINOPIMDECARB-RXN","compounds":"H(+) + meso-2,6-diaminoheptanedioate => CO2 + L-lysine"}
{"X":18271,"RHEA_ID":15103,"compounds":"CO2 + L-lysine => H(+) + meso-2,6-diaminoheptanedioate"}
{"X":18272,"RHEA_ID":24973,"compounds":"calcitetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (1S)-1,25-dihydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin]"}
{"X":18273,"RHEA_ID":15105,"DIRECTION":"UN","MASTER_ID":15105,"ec":"2.1.1.155","compounds":"kaempferol + S-adenosyl-L-methionine = H(+) + kaempferide + S-adenosyl-L-homocysteine"}
{"X":18274,"RHEA_ID":15106,"DIRECTION":"LR","MASTER_ID":15105,"metacyc":"2.1.1.155-RXN","compounds":"kaempferol + S-adenosyl-L-methionine => H(+) + kaempferide + S-adenosyl-L-homocysteine"}
{"X":18275,"RHEA_ID":15107,"compounds":"H(+) + kaempferide + S-adenosyl-L-homocysteine => kaempferol + S-adenosyl-L-methionine"}
{"X":18276,"RHEA_ID":24977,"compounds":"(1S)-1,25-dihydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (1S)-1,23,25-trihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin]"}
{"X":18277,"RHEA_ID":15109,"DIRECTION":"UN","MASTER_ID":15109,"ec":"1.1.1.126","compounds":"2-dehydro-3-deoxy-D-gluconate + NADP(+) = (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + H(+) + NADPH"}
{"X":18278,"RHEA_ID":15110,"compounds":"2-dehydro-3-deoxy-D-gluconate + NADP(+) => (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + H(+) + NADPH"}
{"X":18279,"RHEA_ID":15111,"DIRECTION":"RL","MASTER_ID":15109,"metacyc":"1.1.1.126-RXN","compounds":"(4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + H(+) + NADPH => 2-dehydro-3-deoxy-D-gluconate + NADP(+)"}
{"X":18280,"RHEA_ID":24981,"DIRECTION":"LR","MASTER_ID":24980,"metacyc":"RXN-17074","compounds":"3-hydroxy-4-methylanthranilate + ATP + H(+) => 3-hydroxy-4-methylanthranilyl-5'-AMP + diphosphate"}
{"X":18281,"RHEA_ID":15113,"DIRECTION":"UN","MASTER_ID":15113,"ec":"3.3.2.11","compounds":"5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O = 5alpha-cholestane-3beta,5,6beta-triol"}
{"X":18282,"RHEA_ID":15114,"compounds":"5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O => 5alpha-cholestane-3beta,5,6beta-triol"}
{"X":18283,"RHEA_ID":15115,"compounds":"5alpha-cholestane-3beta,5,6beta-triol => 5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O"}
{"X":18284,"RHEA_ID":24985,"compounds":"(1S)-1,23-dihydroxy-24,25,26,27-tetranorcalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + 2 H2O + 2 oxidized [adrenodoxin]"}
{"X":18285,"RHEA_ID":15117,"DIRECTION":"UN","MASTER_ID":15117,"ec":"2.4.2.52","compounds":"3'-dephospho-CoA + ATP = 2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine"}
{"X":18286,"RHEA_ID":15118,"DIRECTION":"LR","MASTER_ID":15117,"ecocyc":"2.7.8.25-RXN","metacyc":"2.7.8.25-RXN","compounds":"3'-dephospho-CoA + ATP => 2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine"}
{"X":18287,"RHEA_ID":15119,"compounds":"2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine => 3'-dephospho-CoA + ATP"}
{"X":18288,"RHEA_ID":15120,"compounds":"3'-dephospho-CoA + ATP <=> 2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine"}
{"X":18289,"RHEA_ID":15121,"DIRECTION":"UN","MASTER_ID":15121,"ec":"2.8.1.5","metacyc":"2.8.1.5-RXN","compounds":"dithioerythritol + thiosulfate = cis-1,2-dithiane-4,5-diol + 2 H(+) + hydrogen sulfide + sulfite"}
{"X":18290,"RHEA_ID":15122,"compounds":"dithioerythritol + thiosulfate => cis-1,2-dithiane-4,5-diol + 2 H(+) + hydrogen sulfide + sulfite"}
{"X":18291,"RHEA_ID":15123,"compounds":"cis-1,2-dithiane-4,5-diol + 2 H(+) + hydrogen sulfide + sulfite => dithioerythritol + thiosulfate"}
{"X":18292,"RHEA_ID":24993,"DIRECTION":"LR","MASTER_ID":24992,"metacyc":"RXN-12066","compounds":"L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase]"}
{"X":18293,"RHEA_ID":15125,"DIRECTION":"UN","MASTER_ID":15125,"ec":"2.3.1.78","compounds":"acetyl-CoA + alpha-D-glucosaminyl-[heparan sulfate](n) = CoA + H(+) + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n)"}
{"X":18294,"RHEA_ID":15126,"compounds":"acetyl-CoA + alpha-D-glucosaminyl-[heparan sulfate](n) => CoA + H(+) + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n)"}
{"X":18295,"RHEA_ID":15127,"compounds":"CoA + H(+) + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n) => acetyl-CoA + alpha-D-glucosaminyl-[heparan sulfate](n)"}
{"X":18296,"RHEA_ID":24997,"DIRECTION":"LR","MASTER_ID":24996,"metacyc":"RXN-12067","compounds":"N-hydroxy-L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase]"}
{"X":18297,"RHEA_ID":15129,"DIRECTION":"UN","MASTER_ID":15129,"ec":"1.14.14.99","compounds":"(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1S,6R)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":18298,"RHEA_ID":15130,"DIRECTION":"LR","MASTER_ID":15129,"metacyc":"--LIMONENE-3-MONOOXYGENASE-RXN","compounds":"(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] => (1S,6R)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":18299,"RHEA_ID":15131,"compounds":"(1S,6R)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":18300,"RHEA_ID":25001,"DIRECTION":"LR","MASTER_ID":25000,"metacyc":"RXN-12068","compounds":"H(+) + N,N-dihydroxy-L-phenylalanine => (E)-phenylacetaldehyde oxime + CO2 + H2O"}
{"X":18301,"RHEA_ID":15133,"DIRECTION":"UN","MASTER_ID":15133,"ec":"1.4.1.2","compounds":"H2O + L-glutamate + NAD(+) = 2-oxoglutarate + H(+) + NADH + NH4(+)"}
{"X":18302,"RHEA_ID":15133,"DIRECTION":"UN","MASTER_ID":15133,"ec":"1.4.1.3","compounds":"H2O + L-glutamate + NAD(+) = 2-oxoglutarate + H(+) + NADH + NH4(+)"}
{"X":18303,"RHEA_ID":15134,"DIRECTION":"LR","MASTER_ID":15133,"reactome":"R-HSA-70600.4","compounds":"H2O + L-glutamate + NAD(+) => 2-oxoglutarate + H(+) + NADH + NH4(+)"}
{"X":18304,"RHEA_ID":15135,"DIRECTION":"RL","MASTER_ID":15133,"reactome":"R-HSA-70589.4","compounds":"2-oxoglutarate + H(+) + NADH + NH4(+) => H2O + L-glutamate + NAD(+)"}
{"X":18305,"RHEA_ID":25007,"compounds":"2 H(+) + H2O + N-hydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase] => L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":18306,"RHEA_ID":35599,"compounds":"NADP(+) + propane-1,3-diol = 3-hydroxypropanal + H(+) + NADPH"}
{"X":18307,"RHEA_ID":15137,"compounds":"galactitol 1-phosphate + NAD(+) = H(+) + keto-L-tagatose 6-phosphate + NADH"}
{"X":18308,"RHEA_ID":15138,"compounds":"galactitol 1-phosphate + NAD(+) => H(+) + keto-L-tagatose 6-phosphate + NADH"}
{"X":18309,"RHEA_ID":15139,"compounds":"H(+) + keto-L-tagatose 6-phosphate + NADH => galactitol 1-phosphate + NAD(+)"}
{"X":18310,"RHEA_ID":15141,"DIRECTION":"UN","MASTER_ID":15141,"ec":"1.17.9.1","compounds":"4-methylphenol + H2O + 4 oxidized [azurin] = 4-hydroxybenzaldehyde + 4 H(+) + 4 reduced [azurin]"}
{"X":18311,"RHEA_ID":15142,"DIRECTION":"LR","MASTER_ID":15141,"metacyc":"1.17.99.1-RXN","compounds":"4-methylphenol + H2O + 4 oxidized [azurin] => 4-hydroxybenzaldehyde + 4 H(+) + 4 reduced [azurin]"}
{"X":18312,"RHEA_ID":15143,"compounds":"4-hydroxybenzaldehyde + 4 H(+) + 4 reduced [azurin] => 4-methylphenol + H2O + 4 oxidized [azurin]"}
{"X":18313,"RHEA_ID":15145,"DIRECTION":"UN","MASTER_ID":15145,"ec":"5.4.99.16","compounds":"D-maltose = alpha,alpha-trehalose"}
{"X":18314,"RHEA_ID":15146,"compounds":"D-maltose => alpha,alpha-trehalose"}
{"X":18315,"RHEA_ID":15147,"compounds":"alpha,alpha-trehalose => D-maltose"}
{"X":18316,"RHEA_ID":15149,"DIRECTION":"UN","MASTER_ID":15149,"ec":"1.4.3.5","compounds":"O2 + pyridoxine 5'-phosphate = H2O2 + pyridoxal 5'-phosphate"}
{"X":18317,"RHEA_ID":15150,"DIRECTION":"LR","MASTER_ID":15149,"ecocyc":"PNPOXI-RXN","metacyc":"PNPOXI-RXN","reactome":"R-HSA-965019.1","compounds":"O2 + pyridoxine 5'-phosphate => H2O2 + pyridoxal 5'-phosphate"}
{"X":18318,"RHEA_ID":15151,"compounds":"H2O2 + pyridoxal 5'-phosphate => O2 + pyridoxine 5'-phosphate"}
{"X":18319,"RHEA_ID":35615,"compounds":"hydroxyacetone + NAD(+) = H(+) + methylglyoxal + NADH"}
{"X":18320,"RHEA_ID":15153,"DIRECTION":"UN","MASTER_ID":15153,"ec":"2.4.1.194","compounds":"4-hydroxybenzoate + UDP-alpha-D-glucose = 4-(beta-D-glucosyloxy)benzoate + H(+) + UDP"}
{"X":18321,"RHEA_ID":15154,"DIRECTION":"LR","MASTER_ID":15153,"metacyc":"2.4.1.194-RXN","compounds":"4-hydroxybenzoate + UDP-alpha-D-glucose => 4-(beta-D-glucosyloxy)benzoate + H(+) + UDP"}
{"X":18322,"RHEA_ID":15155,"compounds":"4-(beta-D-glucosyloxy)benzoate + H(+) + UDP => 4-hydroxybenzoate + UDP-alpha-D-glucose"}
{"X":18323,"RHEA_ID":25028,"compounds":"H(+) + H2O + S-methyl-5'-thioadenosine <=> NH4(+) + S-methyl-5'-thioinosine"}
{"X":18324,"RHEA_ID":15157,"DIRECTION":"UN","MASTER_ID":15157,"ec":"1.14.13.18","compounds":"4-hydroxyphenylacetate + H(+) + NADPH + O2 = H2O + homogentisate + NADP(+)"}
{"X":18325,"RHEA_ID":15158,"DIRECTION":"LR","MASTER_ID":15157,"metacyc":"1.14.13.18-RXN","compounds":"4-hydroxyphenylacetate + H(+) + NADPH + O2 => H2O + homogentisate + NADP(+)"}
{"X":18326,"RHEA_ID":15159,"compounds":"H2O + homogentisate + NADP(+) => 4-hydroxyphenylacetate + H(+) + NADPH + O2"}
{"X":18327,"RHEA_ID":25032,"compounds":"ADP-D-ribose 1''-phosphate + H2O <=> ADP-D-ribose + phosphate"}
{"X":18328,"RHEA_ID":15161,"DIRECTION":"UN","MASTER_ID":15161,"ec":"1.14.13.18","compounds":"4-hydroxyphenylacetate + H(+) + NADH + O2 = H2O + homogentisate + NAD(+)"}
{"X":18329,"RHEA_ID":15162,"DIRECTION":"LR","MASTER_ID":15161,"metacyc":"1.14.13.18-RXN","compounds":"4-hydroxyphenylacetate + H(+) + NADH + O2 => H2O + homogentisate + NAD(+)"}
{"X":18330,"RHEA_ID":15163,"compounds":"H2O + homogentisate + NAD(+) => 4-hydroxyphenylacetate + H(+) + NADH + O2"}
{"X":18331,"RHEA_ID":25035,"DIRECTION":"RL","MASTER_ID":25033,"reactome":"R-HSA-2465940.1","compounds":"all-trans-retinal + H(+) + NADPH => all-trans-retinol + NADP(+)"}
{"X":18332,"RHEA_ID":15165,"DIRECTION":"UN","MASTER_ID":15165,"ec":"1.4.3.19","compounds":"H2O + O2 + sarcosine = glyoxylate + H2O2 + methylamine"}
{"X":18333,"RHEA_ID":15166,"DIRECTION":"LR","MASTER_ID":15165,"metacyc":"RXN-8673","compounds":"H2O + O2 + sarcosine => glyoxylate + H2O2 + methylamine"}
{"X":18334,"RHEA_ID":15167,"compounds":"glyoxylate + H2O2 + methylamine => H2O + O2 + sarcosine"}
{"X":18335,"RHEA_ID":15169,"DIRECTION":"UN","MASTER_ID":15169,"ec":"3.5.1.96","compounds":"H2O + N-succinyl-L-glutamate = L-glutamate + succinate"}
{"X":18336,"RHEA_ID":15170,"compounds":"H2O + N-succinyl-L-glutamate => L-glutamate + succinate"}
{"X":18337,"RHEA_ID":15171,"compounds":"L-glutamate + succinate => H2O + N-succinyl-L-glutamate"}
{"X":18338,"RHEA_ID":25039,"compounds":"ADP + O-phospho-L-seryl-tRNA(Sec) => ATP + L-seryl-tRNA(Sec)"}
{"X":18339,"RHEA_ID":15173,"DIRECTION":"UN","MASTER_ID":15173,"ec":"1.11.1.2","compounds":"H(+) + H2O2 + NADPH = 2 H2O + NADP(+)"}
{"X":18340,"RHEA_ID":15174,"DIRECTION":"LR","MASTER_ID":15173,"metacyc":"NADPH-PEROXIDASE-RXN","compounds":"H(+) + H2O2 + NADPH => 2 H2O + NADP(+)"}
{"X":18341,"RHEA_ID":15175,"compounds":"2 H2O + NADP(+) => H(+) + H2O2 + NADPH"}
{"X":18342,"RHEA_ID":15177,"DIRECTION":"UN","MASTER_ID":15177,"ec":"3.1.1.5","compounds":"a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine"}
{"X":18343,"RHEA_ID":15178,"DIRECTION":"LR","MASTER_ID":15177,"ecocyc":"LYSOPHOSPHOLIPASE-RXN","metacyc":"LYSOPHOSPHOLIPASE-RXN","compounds":"a 1-acyl-sn-glycero-3-phosphocholine + H2O => a fatty acid + H(+) + sn-glycerol 3-phosphocholine"}
{"X":18344,"RHEA_ID":15179,"compounds":"a fatty acid + H(+) + sn-glycerol 3-phosphocholine => a 1-acyl-sn-glycero-3-phosphocholine + H2O"}
{"X":18345,"RHEA_ID":15181,"DIRECTION":"UN","MASTER_ID":15181,"ec":"7.6.2.4","compounds":"an acyl-CoA(out) + ATP + H2O = ADP + an acyl-CoA(in) + H(+) + phosphate"}
{"X":18346,"RHEA_ID":15182,"compounds":"an acyl-CoA(out) + ATP + H2O => ADP + an acyl-CoA(in) + H(+) + phosphate"}
{"X":18347,"RHEA_ID":15183,"compounds":"ADP + an acyl-CoA(in) + H(+) + phosphate => an acyl-CoA(out) + ATP + H2O"}
{"X":18348,"RHEA_ID":25056,"compounds":"(2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H(+) => (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O2"}
{"X":18349,"RHEA_ID":15185,"DIRECTION":"UN","MASTER_ID":15185,"ec":"2.3.1.109","compounds":"L-arginine + succinyl-CoA = CoA + H(+) + N(2)-succinyl-L-arginine"}
{"X":18350,"RHEA_ID":15186,"compounds":"L-arginine + succinyl-CoA => CoA + H(+) + N(2)-succinyl-L-arginine"}
{"X":18351,"RHEA_ID":15187,"compounds":"CoA + H(+) + N(2)-succinyl-L-arginine => L-arginine + succinyl-CoA"}
{"X":18352,"RHEA_ID":25060,"compounds":"(2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+) => H(+) + NADH + O2 + trans-cinnamate"}
{"X":18353,"RHEA_ID":15189,"DIRECTION":"UN","MASTER_ID":15189,"ec":"1.17.2.3","compounds":"2 [Fe(III)cytochrome c553] + formate = 2 [Fe(II)cytochrome c553] + CO2 + H(+)"}
{"X":18354,"RHEA_ID":15190,"compounds":"2 [Fe(III)cytochrome c553] + formate => 2 [Fe(II)cytochrome c553] + CO2 + H(+)"}
{"X":18355,"RHEA_ID":15191,"compounds":"2 [Fe(II)cytochrome c553] + CO2 + H(+) => 2 [Fe(III)cytochrome c553] + formate"}
{"X":18356,"RHEA_ID":15193,"DIRECTION":"UN","MASTER_ID":15193,"ec":"3.1.5.1","compounds":"dGTP + H2O = 2'-deoxyguanosine + H(+) + triphosphate"}
{"X":18357,"RHEA_ID":15194,"DIRECTION":"LR","MASTER_ID":15193,"ecocyc":"DGTPTRIPHYDRO-RXN","metacyc":"DGTPTRIPHYDRO-RXN","compounds":"dGTP + H2O => 2'-deoxyguanosine + H(+) + triphosphate"}
{"X":18358,"RHEA_ID":15195,"compounds":"2'-deoxyguanosine + H(+) + triphosphate => dGTP + H2O"}
{"X":18359,"RHEA_ID":25068,"compounds":"(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H(+) + NADH => (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+)"}
{"X":18360,"RHEA_ID":15197,"DIRECTION":"UN","MASTER_ID":15197,"ec":"2.1.1.72","compounds":"a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":18361,"RHEA_ID":15198,"DIRECTION":"LR","MASTER_ID":15197,"ecocyc":"2.1.1.72-RXN","metacyc":"2.1.1.72-RXN","compounds":"a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine => an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":18362,"RHEA_ID":15199,"compounds":"an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine => a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine"}
{"X":18363,"RHEA_ID":25072,"compounds":"3-hydroxybenzoyl-CoA + AMP + diphosphate => 3-hydroxybenzoate + ATP + CoA"}
{"X":18364,"RHEA_ID":15201,"DIRECTION":"UN","MASTER_ID":15201,"ec":"2.1.1.108","compounds":"6-hydroxymellein + S-adenosyl-L-methionine = 6-methoxymellein + H(+) + S-adenosyl-L-homocysteine"}
{"X":18365,"RHEA_ID":15202,"DIRECTION":"LR","MASTER_ID":15201,"metacyc":"6-HYDROXYMELLEIN-O-METHYLTRANSFERASE-RXN","compounds":"6-hydroxymellein + S-adenosyl-L-methionine => 6-methoxymellein + H(+) + S-adenosyl-L-homocysteine"}
{"X":18366,"RHEA_ID":15203,"compounds":"6-methoxymellein + H(+) + S-adenosyl-L-homocysteine => 6-hydroxymellein + S-adenosyl-L-methionine"}
{"X":18367,"RHEA_ID":25076,"compounds":"(9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate + H2O => (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate"}
{"X":18368,"RHEA_ID":15205,"DIRECTION":"UN","MASTER_ID":15205,"ec":"3.6.1.44","compounds":"a dolichyl diphosphooligosaccharide + H2O = an oligosaccharide-(1->4)-N-acetyl-beta-D-glucosamine-(1->4)-N-acetyl-alpha-D-glucosamine 1-phosphate + dolichyl phosphate + 2 H(+)"}
{"X":18369,"RHEA_ID":15206,"compounds":"a dolichyl diphosphooligosaccharide + H2O => an oligosaccharide-(1->4)-N-acetyl-beta-D-glucosamine-(1->4)-N-acetyl-alpha-D-glucosamine 1-phosphate + dolichyl phosphate + 2 H(+)"}
{"X":18370,"RHEA_ID":15207,"compounds":"an oligosaccharide-(1->4)-N-acetyl-beta-D-glucosamine-(1->4)-N-acetyl-alpha-D-glucosamine 1-phosphate + dolichyl phosphate + 2 H(+) => a dolichyl diphosphooligosaccharide + H2O"}
{"X":18371,"RHEA_ID":15209,"DIRECTION":"UN","MASTER_ID":15209,"ec":"1.1.1.93","compounds":"(2R,3R)-tartrate + NAD(+) = 2-hydroxy-3-oxosuccinate + H(+) + NADH"}
{"X":18372,"RHEA_ID":15210,"compounds":"(2R,3R)-tartrate + NAD(+) => 2-hydroxy-3-oxosuccinate + H(+) + NADH"}
{"X":18373,"RHEA_ID":15211,"compounds":"2-hydroxy-3-oxosuccinate + H(+) + NADH => (2R,3R)-tartrate + NAD(+)"}
{"X":18374,"RHEA_ID":25095,"DIRECTION":"LR","MASTER_ID":25094,"ecocyc":"RXN-7913","metacyc":"RXN-11831","compounds":"ATP + dCMP => ADP + dCDP"}
{"X":18375,"RHEA_ID":15213,"DIRECTION":"UN","MASTER_ID":15213,"ec":"2.3.1.61","compounds":"(R)-N(6)-dihydrolipoyl-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoA"}
{"X":18376,"RHEA_ID":15214,"DIRECTION":"LR","MASTER_ID":15213,"ecocyc":"RXN0-1147","metacyc":"RXN0-1147","compounds":"(R)-N(6)-dihydrolipoyl-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA => (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoA"}
{"X":18377,"RHEA_ID":15215,"compounds":"(R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoA => (R)-N(6)-dihydrolipoyl-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA"}
{"X":18378,"RHEA_ID":25096,"compounds":"ADP + dCDP => ATP + dCMP"}
{"X":18379,"RHEA_ID":15217,"DIRECTION":"UN","MASTER_ID":15217,"ec":"2.3.1.139","compounds":"ecdysone + hexadecanoyl-CoA = CoA + ecdysone hexadecanoate"}
{"X":18380,"RHEA_ID":15218,"DIRECTION":"LR","MASTER_ID":15217,"metacyc":"ECDYSONE-O-ACYLTRANSFERASE-RXN","compounds":"ecdysone + hexadecanoyl-CoA => CoA + ecdysone hexadecanoate"}
{"X":18381,"RHEA_ID":15219,"compounds":"CoA + ecdysone hexadecanoate => ecdysone + hexadecanoyl-CoA"}
{"X":18382,"RHEA_ID":25100,"compounds":"ADP + UTP => ATP + UDP"}
{"X":18383,"RHEA_ID":15221,"DIRECTION":"UN","MASTER_ID":15221,"ec":"3.6.1.26","compounds":"a CDP-1,2-diacyl-sn-glycerol + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + CMP + 2 H(+)"}
{"X":18384,"RHEA_ID":15222,"compounds":"a CDP-1,2-diacyl-sn-glycerol + H2O => a 1,2-diacyl-sn-glycero-3-phosphate + CMP + 2 H(+)"}
{"X":18385,"RHEA_ID":15223,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphate + CMP + 2 H(+) => a CDP-1,2-diacyl-sn-glycerol + H2O"}
{"X":18386,"RHEA_ID":15225,"DIRECTION":"UN","MASTER_ID":15225,"ec":"2.7.7.24","compounds":"alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose"}
{"X":18387,"RHEA_ID":15226,"compounds":"alpha-D-glucose 1-phosphate + dTTP + H(+) => diphosphate + dTDP-alpha-D-glucose"}
{"X":18388,"RHEA_ID":15227,"compounds":"diphosphate + dTDP-alpha-D-glucose => alpha-D-glucose 1-phosphate + dTTP + H(+)"}
{"X":18389,"RHEA_ID":25110,"compounds":"ADP + H(+) + pyridoxine 5'-phosphate => ATP + pyridoxine"}
{"X":18390,"RHEA_ID":15229,"DIRECTION":"UN","MASTER_ID":15229,"ec":"2.7.7.13","compounds":"alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-alpha-D-mannose"}
{"X":18391,"RHEA_ID":15230,"DIRECTION":"LR","MASTER_ID":15229,"ecocyc":"2.7.7.13-RXN","compounds":"alpha-D-mannose 1-phosphate + GTP + H(+) => diphosphate + GDP-alpha-D-mannose"}
{"X":18392,"RHEA_ID":15231,"compounds":"diphosphate + GDP-alpha-D-mannose => alpha-D-mannose 1-phosphate + GTP + H(+)"}
{"X":18393,"RHEA_ID":25114,"compounds":"phosphate + pyridoxine => H2O + pyridoxine 5'-phosphate"}
{"X":18394,"RHEA_ID":15233,"DIRECTION":"UN","MASTER_ID":15233,"ec":"1.7.2.1","compounds":"[Fe(III)cytochrome c] + H2O + nitric oxide = [Fe(II)cytochrome c] + 2 H(+) + nitrite"}
{"X":18395,"RHEA_ID":15234,"compounds":"[Fe(III)cytochrome c] + H2O + nitric oxide => [Fe(II)cytochrome c] + 2 H(+) + nitrite"}
{"X":18396,"RHEA_ID":15235,"DIRECTION":"RL","MASTER_ID":15233,"metacyc":"NITRITE-REDUCTASE-CYTOCHROME-RXN","compounds":"[Fe(II)cytochrome c] + 2 H(+) + nitrite => [Fe(III)cytochrome c] + H2O + nitric oxide"}
{"X":18397,"RHEA_ID":15237,"DIRECTION":"UN","MASTER_ID":15237,"ec":"1.6.2.5","metacyc":"NADPH--CYTOCHROME-C2-REDUCTASE-RXN","compounds":"2 [Fe(III)-cytochrome c2] + NADPH = 2 [Fe(II)-cytochrome c2] + H(+) + NADP(+)"}
{"X":18398,"RHEA_ID":15238,"compounds":"2 [Fe(III)-cytochrome c2] + NADPH => 2 [Fe(II)-cytochrome c2] + H(+) + NADP(+)"}
{"X":18399,"RHEA_ID":15239,"compounds":"2 [Fe(II)-cytochrome c2] + H(+) + NADP(+) => 2 [Fe(III)-cytochrome c2] + NADPH"}
{"X":18400,"RHEA_ID":15241,"DIRECTION":"UN","MASTER_ID":15241,"ec":"1.14.14.105","compounds":"O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-yl acetate = 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":18401,"RHEA_ID":15242,"DIRECTION":"LR","MASTER_ID":15241,"metacyc":"1.14.13.76-RXN","compounds":"O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-yl acetate => 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":18402,"RHEA_ID":15243,"compounds":"10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-yl acetate"}
{"X":18403,"RHEA_ID":25137,"compounds":"H2O + pyridoxamine 5'-phosphate => phosphate + pyridoxamine"}
{"X":18404,"RHEA_ID":15245,"DIRECTION":"UN","MASTER_ID":15245,"ec":"3.1.1.79","compounds":"a monoacylglycerol + H2O = a fatty acid + glycerol + H(+)"}
{"X":18405,"RHEA_ID":15246,"DIRECTION":"LR","MASTER_ID":15245,"metacyc":"RXN-19280","compounds":"a monoacylglycerol + H2O => a fatty acid + glycerol + H(+)"}
{"X":18406,"RHEA_ID":15247,"compounds":"a fatty acid + glycerol + H(+) => a monoacylglycerol + H2O"}
{"X":18407,"RHEA_ID":15249,"DIRECTION":"UN","MASTER_ID":15249,"ec":"2.4.1.136","compounds":"3,4,5-trihydroxybenzoate + UDP-alpha-D-glucose = 1-O-galloyl-beta-D-glucose + UDP"}
{"X":18408,"RHEA_ID":15250,"DIRECTION":"LR","MASTER_ID":15249,"metacyc":"GALLATE-1-BETA-GLUCOSYLTRANSFERASE-RXN","compounds":"3,4,5-trihydroxybenzoate + UDP-alpha-D-glucose => 1-O-galloyl-beta-D-glucose + UDP"}
{"X":18409,"RHEA_ID":15251,"compounds":"1-O-galloyl-beta-D-glucose + UDP => 3,4,5-trihydroxybenzoate + UDP-alpha-D-glucose"}
{"X":18410,"RHEA_ID":25145,"compounds":"3-hydroxyanthranilate + H(+) + L-alanine => 3-hydroxy-L-kynurenine + H2O"}
{"X":18411,"RHEA_ID":15253,"DIRECTION":"UN","MASTER_ID":15253,"ec":"4.1.1.6","compounds":"cis-aconitate + H(+) = CO2 + itaconate"}
{"X":18412,"RHEA_ID":15254,"DIRECTION":"LR","MASTER_ID":15253,"metacyc":"ACONITATE-DECARBOXYLASE-RXN","compounds":"cis-aconitate + H(+) => CO2 + itaconate"}
{"X":18413,"RHEA_ID":15255,"compounds":"CO2 + itaconate => cis-aconitate + H(+)"}
{"X":18414,"RHEA_ID":25149,"compounds":"H(+) + H2O + quinolinate => (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde"}
{"X":18415,"RHEA_ID":15257,"DIRECTION":"UN","MASTER_ID":15257,"ec":"4.1.2.42","compounds":"D-threonine = acetaldehyde + glycine"}
{"X":18416,"RHEA_ID":15258,"compounds":"D-threonine => acetaldehyde + glycine"}
{"X":18417,"RHEA_ID":15259,"compounds":"acetaldehyde + glycine => D-threonine"}
{"X":18418,"RHEA_ID":15261,"DIRECTION":"UN","MASTER_ID":15261,"ec":"1.14.14.139","compounds":"5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase] = 5beta-cholestane-3alpha,7alpha,12alpha-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":18419,"RHEA_ID":15262,"DIRECTION":"LR","MASTER_ID":15261,"metacyc":"1.14.13.96-RXN","compounds":"5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase] => 5beta-cholestane-3alpha,7alpha,12alpha-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":18420,"RHEA_ID":15263,"compounds":"5beta-cholestane-3alpha,7alpha,12alpha-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":18421,"RHEA_ID":25157,"DIRECTION":"LR","MASTER_ID":25156,"metacyc":"RXN66-555","reactome":"R-HSA-196753.2","compounds":"(R)-4'-phosphopantothenate + ATP + L-cysteine => AMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine"}
{"X":18422,"RHEA_ID":15265,"DIRECTION":"UN","MASTER_ID":15265,"ec":"2.6.99.2","compounds":"1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = H(+) + 2 H2O + phosphate + pyridoxine 5'-phosphate"}
{"X":18423,"RHEA_ID":15266,"DIRECTION":"LR","MASTER_ID":15265,"ecocyc":"PDXJ-RXN","metacyc":"PDXJ-RXN","compounds":"1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate => H(+) + 2 H2O + phosphate + pyridoxine 5'-phosphate"}
{"X":18424,"RHEA_ID":15267,"compounds":"H(+) + 2 H2O + phosphate + pyridoxine 5'-phosphate => 1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate"}
{"X":18425,"RHEA_ID":25161,"DIRECTION":"LR","MASTER_ID":25160,"reactome":"R-HSA-70654.3","compounds":"2-oxoglutarate + L-ornithine => L-glutamate + L-glutamate 5-semialdehyde"}
{"X":18426,"RHEA_ID":15269,"compounds":"L-xylo-hex-3-ulonolactone = H(+) + L-ascorbate"}
{"X":18427,"RHEA_ID":15270,"DIRECTION":"LR","MASTER_ID":15269,"metacyc":"RXN-8784","compounds":"L-xylo-hex-3-ulonolactone => H(+) + L-ascorbate"}
{"X":18428,"RHEA_ID":15271,"compounds":"H(+) + L-ascorbate => L-xylo-hex-3-ulonolactone"}
{"X":18429,"RHEA_ID":25165,"compounds":"A + butanoyl-CoA => (2E)-butenoyl-CoA + AH2"}
{"X":18430,"RHEA_ID":15273,"DIRECTION":"UN","MASTER_ID":15273,"ec":"2.6.1.49","compounds":"2-oxoglutarate + L-dopa = 3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate"}
{"X":18431,"RHEA_ID":15274,"compounds":"2-oxoglutarate + L-dopa => 3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate"}
{"X":18432,"RHEA_ID":15275,"compounds":"3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate => 2-oxoglutarate + L-dopa"}
{"X":18433,"RHEA_ID":25169,"compounds":"6-hydroxyhexan-6-olide => 6-oxohexanoate + H(+)"}
{"X":18434,"RHEA_ID":15277,"DIRECTION":"UN","MASTER_ID":15277,"ec":"2.3.1.108","compounds":"acetyl-CoA + L-lysyl-[alpha-tubulin] = CoA + H(+) + N(6)-acetyl-L-lysyl-[alpha-tubulin]"}
{"X":18435,"RHEA_ID":15278,"compounds":"acetyl-CoA + L-lysyl-[alpha-tubulin] => CoA + H(+) + N(6)-acetyl-L-lysyl-[alpha-tubulin]"}
{"X":18436,"RHEA_ID":15279,"compounds":"CoA + H(+) + N(6)-acetyl-L-lysyl-[alpha-tubulin] => acetyl-CoA + L-lysyl-[alpha-tubulin]"}
{"X":18437,"RHEA_ID":25174,"compounds":"H2O + N(omega)-methyl-L-arginine => L-citrulline + methylamine"}
{"X":18438,"RHEA_ID":15281,"DIRECTION":"UN","MASTER_ID":15281,"ec":"5.3.3.5","compounds":"5alpha-cholest-7-en-3beta-ol = 5alpha-cholest-8-en-3beta-ol"}
{"X":18439,"RHEA_ID":15282,"compounds":"5alpha-cholest-7-en-3beta-ol => 5alpha-cholest-8-en-3beta-ol"}
{"X":18440,"RHEA_ID":15283,"DIRECTION":"RL","MASTER_ID":15281,"metacyc":"RXN66-25","reactome":"R-HSA-6807052.2","compounds":"5alpha-cholest-8-en-3beta-ol => 5alpha-cholest-7-en-3beta-ol"}
{"X":18441,"RHEA_ID":25178,"DIRECTION":"LR","MASTER_ID":25177,"metacyc":"2KETO-4METHYL-PENTANOATE-DEHYDROG-RXN","reactome":"R-HSA-70713.2","compounds":"4-methyl-2-oxopentanoate + CoA + NAD(+) => 3-methylbutanoyl-CoA + CO2 + NADH"}
{"X":18442,"RHEA_ID":15285,"DIRECTION":"UN","MASTER_ID":15285,"ec":"2.5.1.27","compounds":"AMP + dimethylallyl diphosphate = diphosphate + N(6)-(dimethylallyl)adenosine 5'-phosphate"}
{"X":18443,"RHEA_ID":15286,"DIRECTION":"LR","MASTER_ID":15285,"metacyc":"RXN-4307","compounds":"AMP + dimethylallyl diphosphate => diphosphate + N(6)-(dimethylallyl)adenosine 5'-phosphate"}
{"X":18444,"RHEA_ID":15287,"compounds":"diphosphate + N(6)-(dimethylallyl)adenosine 5'-phosphate => AMP + dimethylallyl diphosphate"}
{"X":18445,"RHEA_ID":25182,"DIRECTION":"LR","MASTER_ID":25181,"metacyc":"RXN-0","compounds":"acetyl-CoA + putrescine => CoA + H(+) + N-acetylputrescine"}
{"X":18446,"RHEA_ID":15289,"DIRECTION":"UN","MASTER_ID":15289,"ec":"2.4.2.24","compounds":"[(1->4)-beta-D-xylan](n) + UDP-alpha-D-xylose = [(1->4)-beta-D-xylan](n+1) + H(+) + UDP"}
{"X":18447,"RHEA_ID":15290,"DIRECTION":"LR","MASTER_ID":15289,"metacyc":"RXN-9104","compounds":"[(1->4)-beta-D-xylan](n) + UDP-alpha-D-xylose => [(1->4)-beta-D-xylan](n+1) + H(+) + UDP"}
{"X":18448,"RHEA_ID":15291,"compounds":"[(1->4)-beta-D-xylan](n+1) + H(+) + UDP => [(1->4)-beta-D-xylan](n) + UDP-alpha-D-xylose"}
{"X":18449,"RHEA_ID":25186,"DIRECTION":"LR","MASTER_ID":25185,"metacyc":"DHLAXANAU-RXN","compounds":"1,2-dichloroethane + H2O => 2-chloroethanol + chloride + H(+)"}
{"X":18450,"RHEA_ID":15293,"DIRECTION":"UN","MASTER_ID":15293,"ec":"2.1.1.137","compounds":"arsenite + S-adenosyl-L-methionine = H(+) + methylarsonate + S-adenosyl-L-homocysteine"}
{"X":18451,"RHEA_ID":15294,"DIRECTION":"LR","MASTER_ID":15293,"metacyc":"2.1.1.137-RXN","reactome":"R-HSA-5696220.1","compounds":"arsenite + S-adenosyl-L-methionine => H(+) + methylarsonate + S-adenosyl-L-homocysteine"}
{"X":18452,"RHEA_ID":15295,"compounds":"H(+) + methylarsonate + S-adenosyl-L-homocysteine => arsenite + S-adenosyl-L-methionine"}
{"X":18453,"RHEA_ID":25190,"DIRECTION":"LR","MASTER_ID":25189,"metacyc":"DHLBXANAU-RXN","compounds":"chloroacetate + H2O => chloride + glycolate + H(+)"}
{"X":18454,"RHEA_ID":15297,"DIRECTION":"UN","MASTER_ID":15297,"ec":"2.4.1.133","compounds":"3-O-(beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose = 3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP"}
{"X":18455,"RHEA_ID":15298,"DIRECTION":"LR","MASTER_ID":15297,"metacyc":"2.4.1.133-RXN","compounds":"3-O-(beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose => 3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP"}
{"X":18456,"RHEA_ID":15299,"compounds":"3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose"}
{"X":18457,"RHEA_ID":15301,"DIRECTION":"UN","MASTER_ID":15301,"ec":"1.1.1.114","compounds":"D-apiitol + NAD(+) = aldehydo-D-apiose + H(+) + NADH"}
{"X":18458,"RHEA_ID":15302,"compounds":"D-apiitol + NAD(+) => aldehydo-D-apiose + H(+) + NADH"}
{"X":18459,"RHEA_ID":15303,"DIRECTION":"RL","MASTER_ID":15301,"metacyc":"APIOSE-1-REDUCTASE-RXN","compounds":"aldehydo-D-apiose + H(+) + NADH => D-apiitol + NAD(+)"}
{"X":18460,"RHEA_ID":25198,"DIRECTION":"LR","MASTER_ID":25197,"ecocyc":"RIBOPHOSPHAT-RXN","metacyc":"RIBOPHOSPHAT-RXN","compounds":"5-amino-6-(5-phospho-D-ribitylamino)uracil + H2O => 5-amino-6-(D-ribitylamino)uracil + phosphate"}
{"X":18461,"RHEA_ID":15305,"DIRECTION":"UN","MASTER_ID":15305,"ec":"1.2.1.8","compounds":"betaine aldehyde + H2O + NAD(+) = betaine + 2 H(+) + NADH"}
{"X":18462,"RHEA_ID":15306,"DIRECTION":"LR","MASTER_ID":15305,"ecocyc":"BADH-RXN","macie":"M0100","reactome":"R-HSA-6797955.1","compounds":"betaine aldehyde + H2O + NAD(+) => betaine + 2 H(+) + NADH"}
{"X":18463,"RHEA_ID":15307,"compounds":"betaine + 2 H(+) + NADH => betaine aldehyde + H2O + NAD(+)"}
{"X":18464,"RHEA_ID":25202,"compounds":"D-ribulose 5-phosphate + formaldehyde => D-arabino-hex-3-ulose 6-phosphate"}
{"X":18465,"RHEA_ID":15309,"DIRECTION":"UN","MASTER_ID":15309,"ec":"1.3.7.5","compounds":"(2R,3Z)-phycocyanobilin + 4 oxidized [2Fe-2S]-[ferredoxin] = biliverdin IXalpha + 4 H(+) + 4 reduced [2Fe-2S]-[ferredoxin]"}
{"X":18466,"RHEA_ID":15310,"compounds":"(2R,3Z)-phycocyanobilin + 4 oxidized [2Fe-2S]-[ferredoxin] => biliverdin IXalpha + 4 H(+) + 4 reduced [2Fe-2S]-[ferredoxin]"}
{"X":18467,"RHEA_ID":15311,"DIRECTION":"RL","MASTER_ID":15309,"metacyc":"1.3.7.5-RXN","compounds":"biliverdin IXalpha + 4 H(+) + 4 reduced [2Fe-2S]-[ferredoxin] => (2R,3Z)-phycocyanobilin + 4 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":18468,"RHEA_ID":25210,"DIRECTION":"LR","MASTER_ID":25209,"ecocyc":"UDPACYLGLCNACDEACETYL-RXN","metacyc":"UDPACYLGLCNACDEACETYL-RXN","compounds":"H2O + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine => acetate + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine"}
{"X":18469,"RHEA_ID":15313,"DIRECTION":"UN","MASTER_ID":15313,"ec":"4.3.1.7","compounds":"ethanolamine = acetaldehyde + NH4(+)"}
{"X":18470,"RHEA_ID":15314,"DIRECTION":"LR","MASTER_ID":15313,"ecocyc":"ETHAMLY-RXN","metacyc":"ETHAMLY-RXN","compounds":"ethanolamine => acetaldehyde + NH4(+)"}
{"X":18471,"RHEA_ID":15315,"compounds":"acetaldehyde + NH4(+) => ethanolamine"}
{"X":18472,"RHEA_ID":15317,"DIRECTION":"UN","MASTER_ID":15317,"ec":"3.2.1.112","compounds":"a 2-deoxy-alpha-D-glucoside + H2O = 2-deoxy-D-glucose + an alcohol"}
{"X":18473,"RHEA_ID":15318,"DIRECTION":"LR","MASTER_ID":15317,"metacyc":"2-DEOXYGLUCOSIDASE-RXN","compounds":"a 2-deoxy-alpha-D-glucoside + H2O => 2-deoxy-D-glucose + an alcohol"}
{"X":18474,"RHEA_ID":15319,"compounds":"2-deoxy-D-glucose + an alcohol => a 2-deoxy-alpha-D-glucoside + H2O"}
{"X":18475,"RHEA_ID":15321,"DIRECTION":"UN","MASTER_ID":15321,"ec":"1.14.14.93","compounds":"(6aR,11aR)-3,9-dihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] = (6aS,11aS)-3,6a,9-trihydroxypterocarpan + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":18476,"RHEA_ID":15322,"DIRECTION":"LR","MASTER_ID":15321,"metacyc":"RXN-4505","compounds":"(6aR,11aR)-3,9-dihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] => (6aS,11aS)-3,6a,9-trihydroxypterocarpan + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":18477,"RHEA_ID":15323,"compounds":"(6aS,11aS)-3,6a,9-trihydroxypterocarpan + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (6aR,11aR)-3,9-dihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":18478,"RHEA_ID":25222,"DIRECTION":"LR","MASTER_ID":25221,"metacyc":"CYSTAUR-RXN","compounds":"H(+) + L-cysteate => CO2 + taurine"}
{"X":18479,"RHEA_ID":15325,"DIRECTION":"UN","MASTER_ID":15325,"ec":"2.3.1.15","compounds":"an acyl-CoA + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + CoA"}
{"X":18480,"RHEA_ID":15326,"DIRECTION":"LR","MASTER_ID":15325,"ecocyc":"RXN-1381","metacyc":"RXN-1381","compounds":"an acyl-CoA + sn-glycerol 3-phosphate => a 1-acyl-sn-glycero-3-phosphate + CoA"}
{"X":18481,"RHEA_ID":15327,"compounds":"a 1-acyl-sn-glycero-3-phosphate + CoA => an acyl-CoA + sn-glycerol 3-phosphate"}
{"X":18482,"RHEA_ID":25226,"compounds":"L-arabinitol + NAD(+) => H(+) + L-arabinose + NADH"}
{"X":18483,"RHEA_ID":15329,"DIRECTION":"UN","MASTER_ID":15329,"ec":"1.1.1.154","compounds":"(S)-ureidoglycolate + NAD(+) = H(+) + N-carbamoyl-2-oxoglycine + NADH"}
{"X":18484,"RHEA_ID":15329,"DIRECTION":"UN","MASTER_ID":15329,"ec":"1.1.1.350","compounds":"(S)-ureidoglycolate + NAD(+) = H(+) + N-carbamoyl-2-oxoglycine + NADH"}
{"X":18485,"RHEA_ID":15330,"DIRECTION":"LR","MASTER_ID":15329,"ecocyc":"R165-RXN","metacyc":"R165-RXN","compounds":"(S)-ureidoglycolate + NAD(+) => H(+) + N-carbamoyl-2-oxoglycine + NADH"}
{"X":18486,"RHEA_ID":15330,"DIRECTION":"LR","MASTER_ID":15329,"ecocyc":"R165-RXN","metacyc":"RXN0-7024","compounds":"(S)-ureidoglycolate + NAD(+) => H(+) + N-carbamoyl-2-oxoglycine + NADH"}
{"X":18487,"RHEA_ID":15330,"DIRECTION":"LR","MASTER_ID":15329,"ecocyc":"RXN0-7024","metacyc":"R165-RXN","compounds":"(S)-ureidoglycolate + NAD(+) => H(+) + N-carbamoyl-2-oxoglycine + NADH"}
{"X":18488,"RHEA_ID":15330,"DIRECTION":"LR","MASTER_ID":15329,"ecocyc":"RXN0-7024","metacyc":"RXN0-7024","compounds":"(S)-ureidoglycolate + NAD(+) => H(+) + N-carbamoyl-2-oxoglycine + NADH"}
{"X":18489,"RHEA_ID":15331,"compounds":"H(+) + N-carbamoyl-2-oxoglycine + NADH => (S)-ureidoglycolate + NAD(+)"}
{"X":18490,"RHEA_ID":25233,"DIRECTION":"UN","MASTER_ID":25233,"ec":"5.1.3.24","compounds":"N-acetyl-alpha-neuraminate = N-acetyl-beta-neuraminate"}
{"X":18491,"RHEA_ID":15333,"DIRECTION":"UN","MASTER_ID":15333,"ec":"1.1.1.154","compounds":"(S)-ureidoglycolate + NADP(+) = H(+) + N-carbamoyl-2-oxoglycine + NADPH"}
{"X":18492,"RHEA_ID":15334,"DIRECTION":"LR","MASTER_ID":15333,"ecocyc":"R165-RXN","metacyc":"R165-RXN","compounds":"(S)-ureidoglycolate + NADP(+) => H(+) + N-carbamoyl-2-oxoglycine + NADPH"}
{"X":18493,"RHEA_ID":15335,"compounds":"H(+) + N-carbamoyl-2-oxoglycine + NADPH => (S)-ureidoglycolate + NADP(+)"}
{"X":18494,"RHEA_ID":25237,"DIRECTION":"UN","MASTER_ID":25237,"ec":"2.7.4.6","compounds":"ATP + CDP = ADP + CTP"}
{"X":18495,"RHEA_ID":15337,"DIRECTION":"UN","MASTER_ID":15337,"ec":"3.1.2.25","compounds":"H2O + phenylglyoxylyl-CoA = CoA + H(+) + phenylglyoxylate"}
{"X":18496,"RHEA_ID":15338,"DIRECTION":"LR","MASTER_ID":15337,"metacyc":"3.1.2.25-RXN","compounds":"H2O + phenylglyoxylyl-CoA => CoA + H(+) + phenylglyoxylate"}
{"X":18497,"RHEA_ID":15339,"compounds":"CoA + H(+) + phenylglyoxylate => H2O + phenylglyoxylyl-CoA"}
{"X":18498,"RHEA_ID":25241,"DIRECTION":"UN","MASTER_ID":25241,"ec":"3.5.3.26","compounds":"(S)-2-ureidoglycine + H2O = (S)-ureidoglycolate + NH4(+)"}
{"X":18499,"RHEA_ID":15341,"DIRECTION":"UN","MASTER_ID":15341,"ec":"6.6.1.2","compounds":"ATP + Co(2+) + H2O + hydrogenobyrinate a,c-diamide = ADP + cob(II)yrinate a,c diamide + 5 H(+) + phosphate"}
{"X":18500,"RHEA_ID":15342,"DIRECTION":"LR","MASTER_ID":15341,"metacyc":"R342-RXN","compounds":"ATP + Co(2+) + H2O + hydrogenobyrinate a,c-diamide => ADP + cob(II)yrinate a,c diamide + 5 H(+) + phosphate"}
{"X":18501,"RHEA_ID":15343,"compounds":"ADP + cob(II)yrinate a,c diamide + 5 H(+) + phosphate => ATP + Co(2+) + H2O + hydrogenobyrinate a,c-diamide"}
{"X":18502,"RHEA_ID":25245,"DIRECTION":"UN","MASTER_ID":25245,"ec":"3.1.2.6","compounds":"(R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)"}
{"X":18503,"RHEA_ID":15345,"DIRECTION":"UN","MASTER_ID":15345,"ec":"6.3.2.24","compounds":"ATP + L-arginine + L-tyrosine = AMP + diphosphate + H(+) + L-tyrosyl-L-arginine"}
{"X":18504,"RHEA_ID":15346,"DIRECTION":"LR","MASTER_ID":15345,"metacyc":"TYROSINE--ARGININE-LIGASE-RXN","compounds":"ATP + L-arginine + L-tyrosine => AMP + diphosphate + H(+) + L-tyrosyl-L-arginine"}
{"X":18505,"RHEA_ID":15347,"compounds":"AMP + diphosphate + H(+) + L-tyrosyl-L-arginine => ATP + L-arginine + L-tyrosine"}
{"X":18506,"RHEA_ID":25249,"DIRECTION":"UN","MASTER_ID":25249,"ec":"2.2.1.6","compounds":"H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2"}
{"X":18507,"RHEA_ID":15349,"DIRECTION":"UN","MASTER_ID":15349,"ec":"2.3.1.35","compounds":"L-glutamate + N(2)-acetyl-L-ornithine = L-ornithine + N-acetyl-L-glutamate"}
{"X":18508,"RHEA_ID":15350,"DIRECTION":"LR","MASTER_ID":15349,"metacyc":"GLUTAMATE-N-ACETYLTRANSFERASE-RXN","compounds":"L-glutamate + N(2)-acetyl-L-ornithine => L-ornithine + N-acetyl-L-glutamate"}
{"X":18509,"RHEA_ID":15351,"compounds":"L-ornithine + N-acetyl-L-glutamate => L-glutamate + N(2)-acetyl-L-ornithine"}
{"X":18510,"RHEA_ID":25253,"DIRECTION":"UN","MASTER_ID":25253,"ec":"2.7.1.60","compounds":"ATP + N-acetyl-D-mannosamine = ADP + H(+) + N-acetyl-D-mannosamine 6-phosphate"}
{"X":18511,"RHEA_ID":15353,"compounds":"all-trans-violaxanthin + L-ascorbate = all-trans-antheraxanthin + H2O + L-dehydroascorbate"}
{"X":18512,"RHEA_ID":15354,"DIRECTION":"LR","MASTER_ID":15353,"metacyc":"RXN-7984","compounds":"all-trans-violaxanthin + L-ascorbate => all-trans-antheraxanthin + H2O + L-dehydroascorbate"}
{"X":18513,"RHEA_ID":15355,"compounds":"all-trans-antheraxanthin + H2O + L-dehydroascorbate => all-trans-violaxanthin + L-ascorbate"}
{"X":18514,"RHEA_ID":25257,"DIRECTION":"UN","MASTER_ID":25257,"ec":"5.1.3.9","compounds":"N-acetyl-D-glucosamine 6-phosphate = N-acetyl-D-mannosamine 6-phosphate"}
{"X":18515,"RHEA_ID":15357,"DIRECTION":"UN","MASTER_ID":15357,"ec":"2.4.1.317","compounds":"5-O-beta-D-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose = demethyllactenocin + dTDP + H(+)"}
{"X":18516,"RHEA_ID":15358,"DIRECTION":"LR","MASTER_ID":15357,"metacyc":"RXN-15059","compounds":"5-O-beta-D-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose => demethyllactenocin + dTDP + H(+)"}
{"X":18517,"RHEA_ID":15359,"compounds":"demethyllactenocin + dTDP + H(+) => 5-O-beta-D-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose"}
{"X":18518,"RHEA_ID":25261,"DIRECTION":"UN","MASTER_ID":25261,"metacyc":"RXN-14103","compounds":"2-hydroxyglutarate + FAD + H(+) = 2-oxoglutarate + FADH2"}
{"X":18519,"RHEA_ID":15361,"DIRECTION":"UN","MASTER_ID":15361,"ec":"2.4.2.32","compounds":"dolichyl phosphate + UDP-alpha-D-xylose = dolichyl D-xylosyl phosphate + UDP"}
{"X":18520,"RHEA_ID":15362,"DIRECTION":"LR","MASTER_ID":15361,"metacyc":"2.4.2.32-RXN","compounds":"dolichyl phosphate + UDP-alpha-D-xylose => dolichyl D-xylosyl phosphate + UDP"}
{"X":18521,"RHEA_ID":15363,"compounds":"dolichyl D-xylosyl phosphate + UDP => dolichyl phosphate + UDP-alpha-D-xylose"}
{"X":18522,"RHEA_ID":25265,"DIRECTION":"UN","MASTER_ID":25265,"ec":"1.4.3.21","compounds":"2-phenylethylamine + H2O + O2 = 2-phenylacetaldehyde + H2O2 + NH4(+)"}
{"X":18523,"RHEA_ID":15365,"DIRECTION":"UN","MASTER_ID":15365,"ec":"2.4.2.61","compounds":"3-O-[(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + UDP-alpha-D-xylose = 3-O-[beta-D-xylosyl-(1->4)-(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + H(+) + UDP"}
{"X":18524,"RHEA_ID":15366,"DIRECTION":"LR","MASTER_ID":15365,"metacyc":"RXN-19402","compounds":"3-O-[(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + UDP-alpha-D-xylose => 3-O-[beta-D-xylosyl-(1->4)-(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + H(+) + UDP"}
{"X":18525,"RHEA_ID":15367,"compounds":"3-O-[beta-D-xylosyl-(1->4)-(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + H(+) + UDP => 3-O-[(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + UDP-alpha-D-xylose"}
{"X":18526,"RHEA_ID":15368,"compounds":"3-O-[(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + UDP-alpha-D-xylose <=> 3-O-[beta-D-xylosyl-(1->4)-(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + H(+) + UDP"}
{"X":18527,"RHEA_ID":15369,"DIRECTION":"UN","MASTER_ID":15369,"ec":"1.13.11.28","compounds":"2,3-dihydroxybenzoate + O2 = 2-carboxy-cis,cis-muconate + 2 H(+)"}
{"X":18528,"RHEA_ID":15370,"DIRECTION":"LR","MASTER_ID":15369,"metacyc":"1.13.11.28-RXN","compounds":"2,3-dihydroxybenzoate + O2 => 2-carboxy-cis,cis-muconate + 2 H(+)"}
{"X":18529,"RHEA_ID":15371,"compounds":"2-carboxy-cis,cis-muconate + 2 H(+) => 2,3-dihydroxybenzoate + O2"}
{"X":18530,"RHEA_ID":35839,"compounds":"1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA = a cardiolipin + CoA"}
{"X":18531,"RHEA_ID":15373,"DIRECTION":"UN","MASTER_ID":15373,"ec":"2.1.1.118","compounds":"columbamine + S-adenosyl-L-methionine = H(+) + palmatine + S-adenosyl-L-homocysteine"}
{"X":18532,"RHEA_ID":15374,"DIRECTION":"LR","MASTER_ID":15373,"metacyc":"2.1.1.118-RXN","compounds":"columbamine + S-adenosyl-L-methionine => H(+) + palmatine + S-adenosyl-L-homocysteine"}
{"X":18533,"RHEA_ID":15375,"compounds":"H(+) + palmatine + S-adenosyl-L-homocysteine => columbamine + S-adenosyl-L-methionine"}
{"X":18534,"RHEA_ID":35843,"compounds":"1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 1-acyl-sn-glycero-3-phosphoethanolamine + a cardiolipin"}
{"X":18535,"RHEA_ID":15377,"DIRECTION":"UN","MASTER_ID":15377,"ec":"2.7.1.189","compounds":"(S)-4,5-dihydroxypentane-2,3-dione + ATP = (S)-4-hydroxy-2,3-pentanedione-5-phosphate + ADP + H(+)"}
{"X":18536,"RHEA_ID":15378,"DIRECTION":"LR","MASTER_ID":15377,"ecocyc":"RXN0-5461","metacyc":"RXN0-5461","compounds":"(S)-4,5-dihydroxypentane-2,3-dione + ATP => (S)-4-hydroxy-2,3-pentanedione-5-phosphate + ADP + H(+)"}
{"X":18537,"RHEA_ID":15379,"compounds":"(S)-4-hydroxy-2,3-pentanedione-5-phosphate + ADP + H(+) => (S)-4,5-dihydroxypentane-2,3-dione + ATP"}
{"X":18538,"RHEA_ID":25278,"DIRECTION":"LR","MASTER_ID":25277,"ecocyc":"RXN0-5038","metacyc":"RXN0-5038","reactome":"R-HSA-418553.2","compounds":"3',5'-cyclic AMP + H2O => AMP + H(+)"}
{"X":18539,"RHEA_ID":15381,"DIRECTION":"UN","MASTER_ID":15381,"ec":"1.13.11.24","compounds":"O2 + quercetin = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO"}
{"X":18540,"RHEA_ID":15382,"compounds":"O2 + quercetin => 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO"}
{"X":18541,"RHEA_ID":15383,"compounds":"2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO => O2 + quercetin"}
{"X":18542,"RHEA_ID":25279,"compounds":"AMP + H(+) => 3',5'-cyclic AMP + H2O"}
{"X":18543,"RHEA_ID":15385,"DIRECTION":"UN","MASTER_ID":15385,"ec":"4.2.1.65","compounds":"L-asparagine = 3-cyano-L-alanine + H2O"}
{"X":18544,"RHEA_ID":15386,"compounds":"L-asparagine => 3-cyano-L-alanine + H2O"}
{"X":18545,"RHEA_ID":15387,"compounds":"3-cyano-L-alanine + H2O => L-asparagine"}
{"X":18546,"RHEA_ID":25284,"compounds":"(S)-2,3-epoxysqualene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + squalene"}
{"X":18547,"RHEA_ID":15389,"DIRECTION":"UN","MASTER_ID":15389,"ec":"4.6.1.1","compounds":"ATP = 3',5'-cyclic AMP + diphosphate"}
{"X":18548,"RHEA_ID":15390,"DIRECTION":"LR","MASTER_ID":15389,"ecocyc":"ADENYLATECYC-RXN","macie":"M0058","metacyc":"ADENYLATECYC-RXN","reactome":"R-HSA-392129.4","compounds":"ATP => 3',5'-cyclic AMP + diphosphate"}
{"X":18549,"RHEA_ID":15390,"DIRECTION":"LR","MASTER_ID":15389,"ecocyc":"ADENYLATECYC-RXN","macie":"M0058","metacyc":"ADENYLATECYC-RXN","reactome":"R-HSA-381607.1","compounds":"ATP => 3',5'-cyclic AMP + diphosphate"}
{"X":18550,"RHEA_ID":15390,"DIRECTION":"LR","MASTER_ID":15389,"ecocyc":"ADENYLATECYC-RXN","macie":"M0058","metacyc":"ADENYLATECYC-RXN","reactome":"R-HSA-170676.1","compounds":"ATP => 3',5'-cyclic AMP + diphosphate"}
{"X":18551,"RHEA_ID":15390,"DIRECTION":"LR","MASTER_ID":15389,"ecocyc":"ADENYLATECYC-RXN","macie":"M0058","metacyc":"ADENYLATECYC-RXN","reactome":"R-HSA-111930.4","compounds":"ATP => 3',5'-cyclic AMP + diphosphate"}
{"X":18552,"RHEA_ID":15390,"DIRECTION":"LR","MASTER_ID":15389,"ecocyc":"ADENYLATECYC-RXN","macie":"M0058","metacyc":"ADENYLATECYC-RXN","reactome":"R-HSA-442715.2","compounds":"ATP => 3',5'-cyclic AMP + diphosphate"}
{"X":18553,"RHEA_ID":15390,"DIRECTION":"LR","MASTER_ID":15389,"ecocyc":"ADENYLATECYC-RXN","macie":"M0058","metacyc":"ADENYLATECYC-RXN","reactome":"R-HSA-5610727.2","compounds":"ATP => 3',5'-cyclic AMP + diphosphate"}
{"X":18554,"RHEA_ID":15390,"DIRECTION":"LR","MASTER_ID":15389,"ecocyc":"ADENYLATECYC-RXN","macie":"M0058","metacyc":"ADENYLATECYC-RXN","reactome":"R-HSA-5211224.4","compounds":"ATP => 3',5'-cyclic AMP + diphosphate"}
{"X":18555,"RHEA_ID":15390,"DIRECTION":"LR","MASTER_ID":15389,"ecocyc":"ADENYLATECYC-RXN","macie":"M0058","metacyc":"ADENYLATECYC-RXN","reactome":"R-HSA-164377.2","compounds":"ATP => 3',5'-cyclic AMP + diphosphate"}
{"X":18556,"RHEA_ID":15391,"compounds":"3',5'-cyclic AMP + diphosphate => ATP"}
{"X":18557,"RHEA_ID":25295,"DIRECTION":"LR","MASTER_ID":25294,"metacyc":"RXN66-3","reactome":"R-HSA-71691.2","compounds":"acetaldehyde + H2O + NAD(+) => acetate + 2 H(+) + NADH"}
{"X":18558,"RHEA_ID":15393,"DIRECTION":"UN","MASTER_ID":15393,"ec":"5.1.1.7","compounds":"(2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate"}
{"X":18559,"RHEA_ID":15394,"compounds":"(2S,6S)-2,6-diaminoheptanedioate => meso-2,6-diaminoheptanedioate"}
{"X":18560,"RHEA_ID":15395,"compounds":"meso-2,6-diaminoheptanedioate => (2S,6S)-2,6-diaminoheptanedioate"}
{"X":18561,"RHEA_ID":15397,"DIRECTION":"UN","MASTER_ID":15397,"ec":"4.5.1.3","compounds":"dichloromethane + H2O = 2 chloride + formaldehyde + 2 H(+)"}
{"X":18562,"RHEA_ID":15398,"compounds":"dichloromethane + H2O => 2 chloride + formaldehyde + 2 H(+)"}
{"X":18563,"RHEA_ID":15399,"compounds":"2 chloride + formaldehyde + 2 H(+) => dichloromethane + H2O"}
{"X":18564,"RHEA_ID":15401,"DIRECTION":"UN","MASTER_ID":15401,"ec":"2.4.1.117","compounds":"dolichyl phosphate + UDP-alpha-D-glucose = dolichyl beta-D-glucosyl phosphate + UDP"}
{"X":18565,"RHEA_ID":15402,"DIRECTION":"LR","MASTER_ID":15401,"metacyc":"2.4.1.117-RXN","compounds":"dolichyl phosphate + UDP-alpha-D-glucose => dolichyl beta-D-glucosyl phosphate + UDP"}
{"X":18566,"RHEA_ID":15403,"compounds":"dolichyl beta-D-glucosyl phosphate + UDP => dolichyl phosphate + UDP-alpha-D-glucose"}
{"X":18567,"RHEA_ID":35878,"compounds":"1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA <=> 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}
{"X":18568,"RHEA_ID":15405,"compounds":"(3R)-hydroxybutanoyl-CoA + [(3R)-hydroxybutanoate](n) = [(3R)-hydroxybutanoate](n+1) + CoA"}
{"X":18569,"RHEA_ID":15406,"DIRECTION":"LR","MASTER_ID":15405,"ecocyc":"RXN1-42","metacyc":"RXN1-42","compounds":"(3R)-hydroxybutanoyl-CoA + [(3R)-hydroxybutanoate](n) => [(3R)-hydroxybutanoate](n+1) + CoA"}
{"X":18570,"RHEA_ID":15407,"compounds":"[(3R)-hydroxybutanoate](n+1) + CoA => (3R)-hydroxybutanoyl-CoA + [(3R)-hydroxybutanoate](n)"}
{"X":18571,"RHEA_ID":35882,"compounds":"(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}
{"X":18572,"RHEA_ID":15409,"DIRECTION":"UN","MASTER_ID":15409,"ec":"2.3.1.147","metacyc":"2.3.1.147-RXN","compounds":"1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine = 1-O-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine"}
{"X":18573,"RHEA_ID":15410,"compounds":"1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine => 1-O-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine"}
{"X":18574,"RHEA_ID":15411,"compounds":"1-O-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine => 1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine"}
{"X":18575,"RHEA_ID":15413,"DIRECTION":"UN","MASTER_ID":15413,"ec":"4.2.1.32","compounds":"(2R,3R)-tartrate = H2O + oxaloacetate"}
{"X":18576,"RHEA_ID":15414,"compounds":"(2R,3R)-tartrate => H2O + oxaloacetate"}
{"X":18577,"RHEA_ID":15415,"compounds":"H2O + oxaloacetate => (2R,3R)-tartrate"}
{"X":18578,"RHEA_ID":35890,"compounds":"1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + octadecanoyl-CoA <=> 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":18579,"RHEA_ID":15417,"DIRECTION":"UN","MASTER_ID":15417,"ec":"1.3.1.79","metacyc":"RXN-14476","compounds":"L-arogenate + NADP(+) = CO2 + L-tyrosine + NADPH"}
{"X":18580,"RHEA_ID":15417,"DIRECTION":"UN","MASTER_ID":15417,"ec":"1.3.1.78","metacyc":"RXN-14476","compounds":"L-arogenate + NADP(+) = CO2 + L-tyrosine + NADPH"}
{"X":18581,"RHEA_ID":15418,"DIRECTION":"LR","MASTER_ID":15417,"metacyc":"RXN-5682","compounds":"L-arogenate + NADP(+) => CO2 + L-tyrosine + NADPH"}
{"X":18582,"RHEA_ID":15419,"compounds":"CO2 + L-tyrosine + NADPH => L-arogenate + NADP(+)"}
{"X":18583,"RHEA_ID":25325,"DIRECTION":"UN","MASTER_ID":25325,"ec":"2.1.1.103","compounds":"N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine = H(+) + phosphocholine + S-adenosyl-L-homocysteine"}
{"X":18584,"RHEA_ID":15421,"DIRECTION":"UN","MASTER_ID":15421,"ec":"6.2.1.3","compounds":"a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate"}
{"X":18585,"RHEA_ID":15422,"DIRECTION":"LR","MASTER_ID":15421,"metacyc":"RXN-7904","compounds":"a long-chain fatty acid + ATP + CoA => a long-chain fatty acyl-CoA + AMP + diphosphate"}
{"X":18586,"RHEA_ID":15423,"compounds":"a long-chain fatty acyl-CoA + AMP + diphosphate => a long-chain fatty acid + ATP + CoA"}
{"X":18587,"RHEA_ID":25330,"compounds":"(R)-carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH"}
{"X":18588,"RHEA_ID":15425,"DIRECTION":"UN","MASTER_ID":15425,"ec":"1.3.98.3","compounds":"coproporphyrinogen III + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + 2 CO2 + 2 L-methionine + protoporphyrinogen IX"}
{"X":18589,"RHEA_ID":15426,"DIRECTION":"LR","MASTER_ID":15425,"ecocyc":"HEMN-RXN","metacyc":"HEMN-RXN","compounds":"coproporphyrinogen III + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + 2 CO2 + 2 L-methionine + protoporphyrinogen IX"}
{"X":18590,"RHEA_ID":15427,"compounds":"2 5'-deoxyadenosine + 2 CO2 + 2 L-methionine + protoporphyrinogen IX => coproporphyrinogen III + 2 S-adenosyl-L-methionine"}
{"X":18591,"RHEA_ID":25334,"DIRECTION":"UN","MASTER_ID":25334,"ec":"3.6.1.n3","compounds":"H2O + L-cysteinyl-tRNA(Cys) = H(+) + L-cysteine + tRNA(Cys)"}
{"X":18592,"RHEA_ID":15429,"DIRECTION":"UN","MASTER_ID":15429,"ec":"2.1.1.342","compounds":"heme b + 2 reduced [flavodoxin] + 2 S-adenosyl-L-methionine = 5'-deoxyadenosine + anaerobilin + Fe(2+) + L-methionine + 2 oxidized [flavodoxin] + S-adenosyl-L-homocysteine"}
{"X":18593,"RHEA_ID":15430,"DIRECTION":"LR","MASTER_ID":15429,"metacyc":"RXN-18337","compounds":"heme b + 2 reduced [flavodoxin] + 2 S-adenosyl-L-methionine => 5'-deoxyadenosine + anaerobilin + Fe(2+) + L-methionine + 2 oxidized [flavodoxin] + S-adenosyl-L-homocysteine"}
{"X":18594,"RHEA_ID":15431,"compounds":"5'-deoxyadenosine + anaerobilin + Fe(2+) + L-methionine + 2 oxidized [flavodoxin] + S-adenosyl-L-homocysteine => heme b + 2 reduced [flavodoxin] + 2 S-adenosyl-L-methionine"}
{"X":18595,"RHEA_ID":25338,"compounds":"H(+) + urea = isocyanate + NH4(+)"}
{"X":18596,"RHEA_ID":15433,"DIRECTION":"UN","MASTER_ID":15433,"ec":"2.5.1.70","compounds":"(S)-naringenin + dimethylallyl diphosphate = diphosphate + sophoraflavanone B"}
{"X":18597,"RHEA_ID":15434,"DIRECTION":"LR","MASTER_ID":15433,"metacyc":"2.5.1.70-RXN","compounds":"(S)-naringenin + dimethylallyl diphosphate => diphosphate + sophoraflavanone B"}
{"X":18598,"RHEA_ID":15435,"compounds":"diphosphate + sophoraflavanone B => (S)-naringenin + dimethylallyl diphosphate"}
{"X":18599,"RHEA_ID":25342,"compounds":"H2O + urea = carbamate + NH4(+)"}
{"X":18600,"RHEA_ID":15437,"DIRECTION":"UN","MASTER_ID":15437,"ec":"1.2.1.50","compounds":"a long-chain fatty aldehyde + CoA + NADP(+) = a long-chain fatty acyl-CoA + H(+) + NADPH"}
{"X":18601,"RHEA_ID":15438,"compounds":"a long-chain fatty aldehyde + CoA + NADP(+) => a long-chain fatty acyl-CoA + H(+) + NADPH"}
{"X":18602,"RHEA_ID":15439,"compounds":"a long-chain fatty acyl-CoA + H(+) + NADPH => a long-chain fatty aldehyde + CoA + NADP(+)"}
{"X":18603,"RHEA_ID":25347,"DIRECTION":"UN","MASTER_ID":25347,"ec":"3.6.1.n1","compounds":"D-tyrosyl-tRNA(Tyr) + H2O = D-tyrosine + tRNA(Tyr)"}
{"X":18604,"RHEA_ID":15441,"compounds":"(S)-dihydroorotate + O2 = H2O2 + orotate"}
{"X":18605,"RHEA_ID":15442,"compounds":"(S)-dihydroorotate + O2 => H2O2 + orotate"}
{"X":18606,"RHEA_ID":15443,"compounds":"H2O2 + orotate => (S)-dihydroorotate + O2"}
{"X":18607,"RHEA_ID":15444,"compounds":"(S)-dihydroorotate + O2 <=> H2O2 + orotate"}
{"X":18608,"RHEA_ID":15445,"DIRECTION":"UN","MASTER_ID":15445,"ec":"4.3.1.13","compounds":"H(+) + H2O + O-carbamoyl-L-serine = CO2 + 2 NH4(+) + pyruvate"}
{"X":18609,"RHEA_ID":15446,"DIRECTION":"LR","MASTER_ID":15445,"metacyc":"CARBAMOYL-SERINE-AMMONIA-LYASE-RXN","compounds":"H(+) + H2O + O-carbamoyl-L-serine => CO2 + 2 NH4(+) + pyruvate"}
{"X":18610,"RHEA_ID":15447,"compounds":"CO2 + 2 NH4(+) + pyruvate => H(+) + H2O + O-carbamoyl-L-serine"}
{"X":18611,"RHEA_ID":15449,"DIRECTION":"UN","MASTER_ID":15449,"ec":"1.13.11.5","compounds":"homogentisate + O2 = 4-maleylacetoacetate + H(+)"}
{"X":18612,"RHEA_ID":15450,"DIRECTION":"LR","MASTER_ID":15449,"metacyc":"HOMOGENTISATE-12-DIOXYGENASE-RXN","reactome":"R-HSA-71164.4","compounds":"homogentisate + O2 => 4-maleylacetoacetate + H(+)"}
{"X":18613,"RHEA_ID":15451,"compounds":"4-maleylacetoacetate + H(+) => homogentisate + O2"}
{"X":18614,"RHEA_ID":25359,"DIRECTION":"UN","MASTER_ID":25359,"ec":"1.3.7.6","compounds":"(3Z)-phycoerythrobilin + 2 oxidized 2[4Fe-4S]-[ferredoxin] = biliverdin IXalpha + 4 H(+) + 2 reduced 2[4Fe-4S]-[ferredoxin]"}
{"X":18615,"RHEA_ID":15453,"compounds":"S-adenosyl-L-methionine + sarcosine = H(+) + N,N-dimethylglycine + S-adenosyl-L-homocysteine"}
{"X":18616,"RHEA_ID":15454,"DIRECTION":"LR","MASTER_ID":15453,"metacyc":"RXN-9679","compounds":"S-adenosyl-L-methionine + sarcosine => H(+) + N,N-dimethylglycine + S-adenosyl-L-homocysteine"}
{"X":18617,"RHEA_ID":15455,"compounds":"H(+) + N,N-dimethylglycine + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + sarcosine"}
{"X":18618,"RHEA_ID":25363,"DIRECTION":"UN","MASTER_ID":25363,"ec":"1.1.1.295","compounds":"3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NAD(+) = H(+) + momilactone A + NADH"}
{"X":18619,"RHEA_ID":15457,"DIRECTION":"UN","MASTER_ID":15457,"ec":"1.3.1.19","compounds":"cis-1,2-dihydrobenzene-1,2-diol + NAD(+) = catechol + H(+) + NADH"}
{"X":18620,"RHEA_ID":15458,"DIRECTION":"LR","MASTER_ID":15457,"metacyc":"1.3.1.19-RXN","compounds":"cis-1,2-dihydrobenzene-1,2-diol + NAD(+) => catechol + H(+) + NADH"}
{"X":18621,"RHEA_ID":15459,"compounds":"catechol + H(+) + NADH => cis-1,2-dihydrobenzene-1,2-diol + NAD(+)"}
{"X":18622,"RHEA_ID":25367,"DIRECTION":"UN","MASTER_ID":25367,"ec":"1.1.1.295","compounds":"3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NADP(+) = H(+) + momilactone A + NADPH"}
{"X":18623,"RHEA_ID":15461,"DIRECTION":"UN","MASTER_ID":15461,"ec":"2.8.2.23","compounds":"3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = 3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)"}
{"X":18624,"RHEA_ID":15461,"DIRECTION":"UN","MASTER_ID":15461,"ec":"2.8.2.29","compounds":"3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = 3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)"}
{"X":18625,"RHEA_ID":15461,"DIRECTION":"UN","MASTER_ID":15461,"ec":"2.8.2.30","compounds":"3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = 3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)"}
{"X":18626,"RHEA_ID":15462,"compounds":"3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) => 3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)"}
{"X":18627,"RHEA_ID":15463,"compounds":"3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n)"}
{"X":18628,"RHEA_ID":25373,"compounds":"3-(1-carboxyvinyloxy)anthranilate + FMNH2 => (2S)-2-amino-4-deoxychorismate + FMN"}
{"X":18629,"RHEA_ID":15465,"DIRECTION":"UN","MASTER_ID":15465,"ec":"2.7.1.91","compounds":"ATP + sphinganine = ADP + H(+) + sphinganine 1-phosphate"}
{"X":18630,"RHEA_ID":15466,"DIRECTION":"LR","MASTER_ID":15465,"metacyc":"SPHINGANINE-KINASE-RXN","compounds":"ATP + sphinganine => ADP + H(+) + sphinganine 1-phosphate"}
{"X":18631,"RHEA_ID":15467,"compounds":"ADP + H(+) + sphinganine 1-phosphate => ATP + sphinganine"}
{"X":18632,"RHEA_ID":25377,"compounds":"2-methyl-branched fatty aldehyde + formyl-CoA => 2-hydroxy-3-methyl fatty acyl-CoA"}
{"X":18633,"RHEA_ID":15469,"DIRECTION":"UN","MASTER_ID":15469,"ec":"5.3.1.16","compounds":"1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide"}
{"X":18634,"RHEA_ID":15470,"DIRECTION":"LR","MASTER_ID":15469,"ecocyc":"PRIBFAICARPISOM-RXN","metacyc":"PRIBFAICARPISOM-RXN","compounds":"1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide => 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide"}
{"X":18635,"RHEA_ID":15471,"compounds":"5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide => 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide"}
{"X":18636,"RHEA_ID":25381,"compounds":"2-methylpentadecanal + formyl-CoA => 2-hydroxy-3-methylhexadecanoyl-CoA"}
{"X":18637,"RHEA_ID":15473,"DIRECTION":"UN","MASTER_ID":15473,"ec":"2.4.1.236","compounds":"flavanone 7-O-beta-D-glucoside + UDP-beta-L-rhamnose = flavanone 7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucoside] + H(+) + UDP"}
{"X":18638,"RHEA_ID":15474,"compounds":"flavanone 7-O-beta-D-glucoside + UDP-beta-L-rhamnose => flavanone 7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucoside] + H(+) + UDP"}
{"X":18639,"RHEA_ID":15475,"compounds":"flavanone 7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucoside] + H(+) + UDP => flavanone 7-O-beta-D-glucoside + UDP-beta-L-rhamnose"}
{"X":18640,"RHEA_ID":25393,"compounds":"cis-3,4-dehydroadipyl-CoA + 2 H(+) + NADPH => (3Z)-6-oxohex-3-enoyl-CoA + H2O + NADP(+)"}
{"X":18641,"RHEA_ID":15477,"DIRECTION":"UN","MASTER_ID":15477,"ec":"2.8.2.32","metacyc":"2.8.2.32-RXN","compounds":"3'-phosphoadenylyl sulfate + 5beta-scymnol = 5beta-scymnol sulfate + adenosine 3',5'-bisphosphate + H(+)"}
{"X":18642,"RHEA_ID":15478,"compounds":"3'-phosphoadenylyl sulfate + 5beta-scymnol => 5beta-scymnol sulfate + adenosine 3',5'-bisphosphate + H(+)"}
{"X":18643,"RHEA_ID":15479,"compounds":"5beta-scymnol sulfate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 5beta-scymnol"}
{"X":18644,"RHEA_ID":25397,"compounds":"(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate => (9Z,12Z)-octadecadienoate + O2"}
{"X":18645,"RHEA_ID":15481,"DIRECTION":"UN","MASTER_ID":15481,"ec":"2.1.2.1","compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine"}
{"X":18646,"RHEA_ID":15482,"compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O => (6S)-5,6,7,8-tetrahydrofolate + L-serine"}
{"X":18647,"RHEA_ID":15483,"DIRECTION":"RL","MASTER_ID":15481,"macie":"M0147","compounds":"(6S)-5,6,7,8-tetrahydrofolate + L-serine => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O"}
{"X":18648,"RHEA_ID":25401,"compounds":"(7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate => (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate"}
{"X":18649,"RHEA_ID":15485,"DIRECTION":"UN","MASTER_ID":15485,"ec":"4.2.1.36","compounds":"(1R,2S)-homoisocitrate = cis-homoaconitate + H2O"}
{"X":18650,"RHEA_ID":15486,"compounds":"(1R,2S)-homoisocitrate => cis-homoaconitate + H2O"}
{"X":18651,"RHEA_ID":15487,"DIRECTION":"RL","MASTER_ID":15485,"metacyc":"HOMOACONITATE-HYDRATASE-RXN","compounds":"cis-homoaconitate + H2O => (1R,2S)-homoisocitrate"}
{"X":18652,"RHEA_ID":25406,"compounds":"(R)-3-hydroxy-3-methyl-2-oxopentanoate => (S)-2-ethyl-2-hydroxy-3-oxobutanoate"}
{"X":18653,"RHEA_ID":15489,"DIRECTION":"UN","MASTER_ID":15489,"ec":"1.1.3.39","compounds":"adenosine + H2O + 2 O2 = 9-riburonosyladenine + H(+) + 2 H2O2"}
{"X":18654,"RHEA_ID":15490,"DIRECTION":"LR","MASTER_ID":15489,"metacyc":"1.1.3.39-RXN","compounds":"adenosine + H2O + 2 O2 => 9-riburonosyladenine + H(+) + 2 H2O2"}
{"X":18655,"RHEA_ID":15491,"compounds":"9-riburonosyladenine + H(+) + 2 H2O2 => adenosine + H2O + 2 O2"}
{"X":18656,"RHEA_ID":25410,"compounds":"ADP + alpha,alpha-trehalose + H(+) => ADP-alpha-D-glucose + D-glucose"}
{"X":18657,"RHEA_ID":15493,"compounds":"A + H2O + N2 = AH2 + nitrous oxide"}
{"X":18658,"RHEA_ID":15494,"compounds":"A + H2O + N2 => AH2 + nitrous oxide"}
{"X":18659,"RHEA_ID":15495,"compounds":"AH2 + nitrous oxide => A + H2O + N2"}
{"X":18660,"RHEA_ID":15497,"DIRECTION":"UN","MASTER_ID":15497,"ec":"2.6.1.56","compounds":"1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate = 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine"}
{"X":18661,"RHEA_ID":15498,"compounds":"1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate => 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine"}
{"X":18662,"RHEA_ID":15499,"compounds":"1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine => 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate"}
{"X":18663,"RHEA_ID":25422,"compounds":"3-hydroxycyclohexa-1,5-diene-1-carbonyl-CoA + A + 2 ADP + 2 H(+) + 2 phosphate => 3-hydroxybenzoyl-CoA + AH2 + 2 ATP + 2 H2O"}
{"X":18664,"RHEA_ID":15501,"DIRECTION":"UN","MASTER_ID":15501,"ec":"1.4.1.13","compounds":"2 L-glutamate + NADP(+) = 2-oxoglutarate + H(+) + L-glutamine + NADPH"}
{"X":18665,"RHEA_ID":15502,"compounds":"2 L-glutamate + NADP(+) => 2-oxoglutarate + H(+) + L-glutamine + NADPH"}
{"X":18666,"RHEA_ID":15503,"DIRECTION":"RL","MASTER_ID":15501,"ecocyc":"GLUTAMATESYN-RXN","macie":"M0304","metacyc":"GLUTAMATESYN-RXN","compounds":"2-oxoglutarate + H(+) + L-glutamine + NADPH => 2 L-glutamate + NADP(+)"}
{"X":18667,"RHEA_ID":25426,"DIRECTION":"RL","MASTER_ID":25424,"ecocyc":"GUANPRIBOSYLTRAN-RXN","macie":"M0048","compounds":"5-phospho-alpha-D-ribose 1-diphosphate + guanine => diphosphate + GMP"}
{"X":18668,"RHEA_ID":15505,"DIRECTION":"UN","MASTER_ID":15505,"ec":"1.1.1.291","compounds":"2-(hydroxymethyl)glutarate + NAD(+) = 2-formylglutarate + H(+) + NADH"}
{"X":18669,"RHEA_ID":15506,"compounds":"2-(hydroxymethyl)glutarate + NAD(+) => 2-formylglutarate + H(+) + NADH"}
{"X":18670,"RHEA_ID":15507,"DIRECTION":"RL","MASTER_ID":15505,"metacyc":"1.1.1.291-RXN","compounds":"2-formylglutarate + H(+) + NADH => 2-(hydroxymethyl)glutarate + NAD(+)"}
{"X":18671,"RHEA_ID":25430,"compounds":"ADP + H(+) + N-acetyl-alpha-D-hexosamine 1-phosphate => ATP + N-acetyl-D-hexosamine"}
{"X":18672,"RHEA_ID":15509,"DIRECTION":"UN","MASTER_ID":15509,"ec":"2.4.1.144","compounds":"N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP"}
{"X":18673,"RHEA_ID":15510,"DIRECTION":"LR","MASTER_ID":15509,"metacyc":"2.4.1.144-RXN","compounds":"N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP"}
{"X":18674,"RHEA_ID":15511,"compounds":"H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":18675,"RHEA_ID":15513,"DIRECTION":"UN","MASTER_ID":15513,"ec":"2.7.1.101","compounds":"ATP + keto-D-tagatose = ADP + H(+) + keto-D-tagatose 6-phosphate"}
{"X":18676,"RHEA_ID":15514,"DIRECTION":"LR","MASTER_ID":15513,"metacyc":"TAGATOSE-KINASE-RXN","compounds":"ATP + keto-D-tagatose => ADP + H(+) + keto-D-tagatose 6-phosphate"}
{"X":18677,"RHEA_ID":15515,"compounds":"ADP + H(+) + keto-D-tagatose 6-phosphate => ATP + keto-D-tagatose"}
{"X":18678,"RHEA_ID":25438,"compounds":"(E,R)-alpha-bisabolene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":18679,"RHEA_ID":15517,"DIRECTION":"UN","MASTER_ID":15517,"ec":"3.1.6.11","compounds":"H2O + N(2),6-disulfo-D-glucosamine = H(+) + N-sulfo-D-glucosamine + sulfate"}
{"X":18680,"RHEA_ID":15518,"DIRECTION":"LR","MASTER_ID":15517,"metacyc":"DISULFOGLUCOSAMINE-6-SULFATASE-RXN","compounds":"H2O + N(2),6-disulfo-D-glucosamine => H(+) + N-sulfo-D-glucosamine + sulfate"}
{"X":18681,"RHEA_ID":15519,"compounds":"H(+) + N-sulfo-D-glucosamine + sulfate => H2O + N(2),6-disulfo-D-glucosamine"}
{"X":18682,"RHEA_ID":25442,"compounds":"delta-selinene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":18683,"RHEA_ID":15521,"DIRECTION":"UN","MASTER_ID":15521,"ec":"2.3.1.97","compounds":"N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycyl-[protein]"}
{"X":18684,"RHEA_ID":15522,"compounds":"N-terminal glycyl-[protein] + tetradecanoyl-CoA => CoA + H(+) + N-tetradecanoylglycyl-[protein]"}
{"X":18685,"RHEA_ID":15523,"compounds":"CoA + H(+) + N-tetradecanoylglycyl-[protein] => N-terminal glycyl-[protein] + tetradecanoyl-CoA"}
{"X":18686,"RHEA_ID":25445,"DIRECTION":"LR","MASTER_ID":25444,"metacyc":"RXN-8553","compounds":"(2E,6E)-farnesyl diphosphate => (1E,4E)-germacrene B + diphosphate"}
{"X":18687,"RHEA_ID":15525,"compounds":"2-succinylbenzoyl-CoA = 1,4-dihydroxy-2-naphthoate + CoA"}
{"X":18688,"RHEA_ID":15526,"compounds":"2-succinylbenzoyl-CoA => 1,4-dihydroxy-2-naphthoate + CoA"}
{"X":18689,"RHEA_ID":15527,"compounds":"1,4-dihydroxy-2-naphthoate + CoA => 2-succinylbenzoyl-CoA"}
{"X":18690,"RHEA_ID":25449,"DIRECTION":"LR","MASTER_ID":25448,"metacyc":"RXN-8557","compounds":"(2E,6E)-farnesyl diphosphate => (+)-guaia-6,9-diene + diphosphate"}
{"X":18691,"RHEA_ID":15529,"DIRECTION":"UN","MASTER_ID":15529,"ec":"3.1.1.60","compounds":"bis(2-ethylhexyl)phthalate + H2O = 2-ethylhexan-1-ol + 2-ethylhexyl phthalate + H(+)"}
{"X":18692,"RHEA_ID":15530,"DIRECTION":"LR","MASTER_ID":15529,"metacyc":"BIS2-ETHYLHEXYLPHTHALATE-ESTERASE-RXN","compounds":"bis(2-ethylhexyl)phthalate + H2O => 2-ethylhexan-1-ol + 2-ethylhexyl phthalate + H(+)"}
{"X":18693,"RHEA_ID":15531,"compounds":"2-ethylhexan-1-ol + 2-ethylhexyl phthalate + H(+) => bis(2-ethylhexyl)phthalate + H2O"}
{"X":18694,"RHEA_ID":25453,"compounds":"(2E,6E)-farnesyl diphosphate => diphosphate + germacrene A"}
{"X":18695,"RHEA_ID":15533,"compounds":"(R)-3-sulfolactate + NAD(+) = 3-sulfopyruvate + H(+) + NADH"}
{"X":18696,"RHEA_ID":15534,"compounds":"(R)-3-sulfolactate + NAD(+) => 3-sulfopyruvate + H(+) + NADH"}
{"X":18697,"RHEA_ID":15535,"compounds":"3-sulfopyruvate + H(+) + NADH => (R)-3-sulfolactate + NAD(+)"}
{"X":18698,"RHEA_ID":25457,"DIRECTION":"LR","MASTER_ID":25456,"metacyc":"RXN-8541","compounds":"(2E,6E)-farnesyl diphosphate => diphosphate + gamma-humulene"}
{"X":18699,"RHEA_ID":15537,"DIRECTION":"UN","MASTER_ID":15537,"ec":"1.1.1.338","compounds":"(R)-3-sulfolactate + NADP(+) = 3-sulfopyruvate + H(+) + NADPH"}
{"X":18700,"RHEA_ID":15538,"compounds":"(R)-3-sulfolactate + NADP(+) => 3-sulfopyruvate + H(+) + NADPH"}
{"X":18701,"RHEA_ID":15539,"compounds":"3-sulfopyruvate + H(+) + NADPH => (R)-3-sulfolactate + NADP(+)"}
{"X":18702,"RHEA_ID":25461,"DIRECTION":"LR","MASTER_ID":25460,"metacyc":"RXN-8542","compounds":"(2E,6E)-farnesyl diphosphate => diphosphate + sibirene"}
{"X":18703,"RHEA_ID":15541,"DIRECTION":"UN","MASTER_ID":15541,"ec":"2.4.1.202","compounds":"DIMBOA + UDP-alpha-D-glucose = DIMBOA beta-D-glucoside + H(+) + UDP"}
{"X":18704,"RHEA_ID":15542,"compounds":"DIMBOA + UDP-alpha-D-glucose => DIMBOA beta-D-glucoside + H(+) + UDP"}
{"X":18705,"RHEA_ID":15543,"compounds":"DIMBOA beta-D-glucoside + H(+) + UDP => DIMBOA + UDP-alpha-D-glucose"}
{"X":18706,"RHEA_ID":25464,"DIRECTION":"UN","MASTER_ID":25464,"ec":"4.2.3.58","compounds":"(2E,6E)-farnesyl diphosphate = diphosphate + longifolene"}
{"X":18707,"RHEA_ID":25465,"DIRECTION":"LR","MASTER_ID":25464,"metacyc":"RXN-8540","compounds":"(2E,6E)-farnesyl diphosphate => diphosphate + longifolene"}
{"X":18708,"RHEA_ID":15545,"DIRECTION":"UN","MASTER_ID":15545,"ec":"4.1.3.22","compounds":"(3S)-citramalate = acetate + pyruvate"}
{"X":18709,"RHEA_ID":15546,"compounds":"(3S)-citramalate => acetate + pyruvate"}
{"X":18710,"RHEA_ID":15547,"compounds":"acetate + pyruvate => (3S)-citramalate"}
{"X":18711,"RHEA_ID":15549,"DIRECTION":"UN","MASTER_ID":15549,"ec":"4.2.1.109","compounds":"5-methylsulfanyl-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O"}
{"X":18712,"RHEA_ID":15550,"DIRECTION":"LR","MASTER_ID":15549,"metacyc":"R145-RXN","reactome":"R-HSA-1237140.1","compounds":"5-methylsulfanyl-D-ribulose 1-phosphate => 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O"}
{"X":18713,"RHEA_ID":15551,"compounds":"5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O => 5-methylsulfanyl-D-ribulose 1-phosphate"}
{"X":18714,"RHEA_ID":25473,"DIRECTION":"LR","MASTER_ID":25472,"metacyc":"RXN-8545","compounds":"(2E,6E)-farnesyl diphosphate => diphosphate + gamma-himachalene"}
{"X":18715,"RHEA_ID":15553,"DIRECTION":"UN","MASTER_ID":15553,"ec":"3.1.3.57","compounds":"1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate"}
{"X":18716,"RHEA_ID":15554,"DIRECTION":"LR","MASTER_ID":15553,"metacyc":"3.1.3.57-RXN","reactome":"R-HSA-1855208.2","compounds":"1D-myo-inositol 1,4-bisphosphate + H2O => 1D-myo-inositol 4-phosphate + phosphate"}
{"X":18717,"RHEA_ID":15555,"compounds":"1D-myo-inositol 4-phosphate + phosphate => 1D-myo-inositol 1,4-bisphosphate + H2O"}
{"X":18718,"RHEA_ID":25477,"DIRECTION":"LR","MASTER_ID":25476,"metacyc":"RXN-8543","compounds":"(2E,6E)-farnesyl diphosphate => alpha-himachalene + diphosphate"}
{"X":18719,"RHEA_ID":15557,"DIRECTION":"UN","MASTER_ID":15557,"ec":"7.2.2.11","compounds":"ATP + H2O + Ni(2+)(out) = ADP + H(+) + Ni(2+)(in) + phosphate"}
{"X":18720,"RHEA_ID":15558,"DIRECTION":"LR","MASTER_ID":15557,"ecocyc":"ABC-20-RXN","metacyc":"3.6.3.24-RXN","compounds":"ATP + H2O + Ni(2+)(out) => ADP + H(+) + Ni(2+)(in) + phosphate"}
{"X":18721,"RHEA_ID":15559,"compounds":"ADP + H(+) + Ni(2+)(in) + phosphate => ATP + H2O + Ni(2+)(out)"}
{"X":18722,"RHEA_ID":15560,"compounds":"ATP + H2O + Ni(2+)(out) <=> ADP + H(+) + Ni(2+)(in) + phosphate"}
{"X":18723,"RHEA_ID":15561,"DIRECTION":"UN","MASTER_ID":15561,"ec":"2.1.1.110","compounds":"S-adenosyl-L-methionine + sterigmatocystin = 8-O-methylsterigmatocystin + H(+) + S-adenosyl-L-homocysteine"}
{"X":18724,"RHEA_ID":15562,"DIRECTION":"LR","MASTER_ID":15561,"metacyc":"2.1.1.110-RXN","compounds":"S-adenosyl-L-methionine + sterigmatocystin => 8-O-methylsterigmatocystin + H(+) + S-adenosyl-L-homocysteine"}
{"X":18725,"RHEA_ID":15563,"compounds":"8-O-methylsterigmatocystin + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + sterigmatocystin"}
{"X":18726,"RHEA_ID":25485,"DIRECTION":"LR","MASTER_ID":25484,"metacyc":"RXN-5142","compounds":"(2E)-geranyl diphosphate => (1S,4R)-camphene + diphosphate"}
{"X":18727,"RHEA_ID":15565,"DIRECTION":"UN","MASTER_ID":15565,"ec":"3.5.1.14","compounds":"an N-acyl-L-amino acid + H2O = a carboxylate + an L-alpha-amino acid"}
{"X":18728,"RHEA_ID":15566,"DIRECTION":"LR","MASTER_ID":15565,"metacyc":"AMINOACYLASE-RXN","compounds":"an N-acyl-L-amino acid + H2O => a carboxylate + an L-alpha-amino acid"}
{"X":18729,"RHEA_ID":15567,"compounds":"a carboxylate + an L-alpha-amino acid => an N-acyl-L-amino acid + H2O"}
{"X":18730,"RHEA_ID":15573,"DIRECTION":"UN","MASTER_ID":15573,"ec":"2.1.1.4","compounds":"N-acetylserotonin + S-adenosyl-L-methionine = H(+) + melatonin + S-adenosyl-L-homocysteine"}
{"X":18731,"RHEA_ID":15574,"DIRECTION":"LR","MASTER_ID":15573,"metacyc":"ACETYLSEROTONIN-O-METHYLTRANSFERASE-RXN","reactome":"R-HSA-209821.1","compounds":"N-acetylserotonin + S-adenosyl-L-methionine => H(+) + melatonin + S-adenosyl-L-homocysteine"}
{"X":18732,"RHEA_ID":15575,"compounds":"H(+) + melatonin + S-adenosyl-L-homocysteine => N-acetylserotonin + S-adenosyl-L-methionine"}
{"X":18733,"RHEA_ID":25493,"DIRECTION":"LR","MASTER_ID":25492,"metacyc":"RXN-5143","compounds":"(2E)-geranyl diphosphate => (-)-beta-phellandrene + diphosphate"}
{"X":18734,"RHEA_ID":15577,"DIRECTION":"UN","MASTER_ID":15577,"ec":"3.2.2.3","compounds":"H2O + uridine = D-ribose + uracil"}
{"X":18735,"RHEA_ID":15577,"DIRECTION":"UN","MASTER_ID":15577,"ec":"3.2.2.8","compounds":"H2O + uridine = D-ribose + uracil"}
{"X":18736,"RHEA_ID":15578,"DIRECTION":"LR","MASTER_ID":15577,"ecocyc":"URIDINE-NUCLEOSIDASE-RXN","metacyc":"URIDINE-NUCLEOSIDASE-RXN","compounds":"H2O + uridine => D-ribose + uracil"}
{"X":18737,"RHEA_ID":15579,"compounds":"D-ribose + uracil => H2O + uridine"}
{"X":18738,"RHEA_ID":25498,"compounds":"(1S,5S)-beta-pinene + diphosphate => (2E)-geranyl diphosphate"}
{"X":18739,"RHEA_ID":15581,"DIRECTION":"UN","MASTER_ID":15581,"ec":"2.3.1.115","compounds":"biochanin A 7-O-beta-D-glucoside + malonyl-CoA = biochanin A 7-O-beta-D-glucoside 6''-O-malonate + CoA"}
{"X":18740,"RHEA_ID":15582,"DIRECTION":"LR","MASTER_ID":15581,"metacyc":"2.3.1.115-RXN","compounds":"biochanin A 7-O-beta-D-glucoside + malonyl-CoA => biochanin A 7-O-beta-D-glucoside 6''-O-malonate + CoA"}
{"X":18741,"RHEA_ID":15583,"compounds":"biochanin A 7-O-beta-D-glucoside 6''-O-malonate + CoA => biochanin A 7-O-beta-D-glucoside + malonyl-CoA"}
{"X":18742,"RHEA_ID":25502,"compounds":"diphosphate + terpinolene => (2E)-geranyl diphosphate"}
{"X":18743,"RHEA_ID":15585,"DIRECTION":"UN","MASTER_ID":15585,"ec":"1.3.99.31","compounds":"15-cis-phytoene + 4 A = 4 AH2 + all-trans-lycopene"}
{"X":18744,"RHEA_ID":15586,"compounds":"15-cis-phytoene + 4 A => 4 AH2 + all-trans-lycopene"}
{"X":18745,"RHEA_ID":15587,"compounds":"4 AH2 + all-trans-lycopene => 15-cis-phytoene + 4 A"}
{"X":18746,"RHEA_ID":25506,"compounds":"beta-phellandrene + diphosphate => (2E)-geranyl diphosphate"}
{"X":18747,"RHEA_ID":15589,"DIRECTION":"UN","MASTER_ID":15589,"ec":"2.6.1.72","compounds":"2-oxoglutarate + D-4-hydroxyphenylglycine = 4-hydroxyphenylglyoxylate + L-glutamate"}
{"X":18748,"RHEA_ID":15590,"compounds":"2-oxoglutarate + D-4-hydroxyphenylglycine => 4-hydroxyphenylglyoxylate + L-glutamate"}
{"X":18749,"RHEA_ID":15591,"compounds":"4-hydroxyphenylglyoxylate + L-glutamate => 2-oxoglutarate + D-4-hydroxyphenylglycine"}
{"X":18750,"RHEA_ID":25510,"compounds":"(1S,5S)-sabinene + diphosphate => (2E)-geranyl diphosphate"}
{"X":18751,"RHEA_ID":15593,"DIRECTION":"UN","MASTER_ID":15593,"ec":"3.1.3.107","compounds":"amicoumacin A 2-phosphate + H2O = amicoumacin A + phosphate"}
{"X":18752,"RHEA_ID":15594,"DIRECTION":"LR","MASTER_ID":15593,"metacyc":"RXN-20946","compounds":"amicoumacin A 2-phosphate + H2O => amicoumacin A + phosphate"}
{"X":18753,"RHEA_ID":15595,"compounds":"amicoumacin A + phosphate => amicoumacin A 2-phosphate + H2O"}
{"X":18754,"RHEA_ID":25514,"compounds":"chorismate + L-glutamine => (2S)-2-amino-4-deoxychorismate + L-glutamate"}
{"X":18755,"RHEA_ID":15597,"compounds":"a Fe(III)-siderophore(out) + ATP + H2O = a Fe(III)-siderophore(in) + ADP + H(+) + phosphate"}
{"X":18756,"RHEA_ID":15598,"DIRECTION":"LR","MASTER_ID":15597,"metacyc":"3.6.3.34-RXN","compounds":"a Fe(III)-siderophore(out) + ATP + H2O => a Fe(III)-siderophore(in) + ADP + H(+) + phosphate"}
{"X":18757,"RHEA_ID":15599,"compounds":"a Fe(III)-siderophore(in) + ADP + H(+) + phosphate => a Fe(III)-siderophore(out) + ATP + H2O"}
{"X":18758,"RHEA_ID":15600,"compounds":"a Fe(III)-siderophore(out) + ATP + H2O <=> a Fe(III)-siderophore(in) + ADP + H(+) + phosphate"}
{"X":18759,"RHEA_ID":15601,"DIRECTION":"UN","MASTER_ID":15601,"ec":"2.8.3.17","compounds":"(E)-cinnamoyl-CoA + (R)-3-phenyllactate = (R)-3-phenyllactoyl-CoA + trans-cinnamate"}
{"X":18760,"RHEA_ID":15602,"compounds":"(E)-cinnamoyl-CoA + (R)-3-phenyllactate => (R)-3-phenyllactoyl-CoA + trans-cinnamate"}
{"X":18761,"RHEA_ID":15603,"compounds":"(R)-3-phenyllactoyl-CoA + trans-cinnamate => (E)-cinnamoyl-CoA + (R)-3-phenyllactate"}
{"X":18762,"RHEA_ID":25522,"compounds":"CoA + H(+) + O-acylpseudotropine => an acyl-CoA + pseudotropine"}
{"X":18763,"RHEA_ID":15605,"DIRECTION":"UN","MASTER_ID":15605,"ec":"4.3.1.10","metacyc":"SERINE-SULFATE-AMMONIA-LYASE-RXN","compounds":"H2O + L-serine O-sulfate = H(+) + NH4(+) + pyruvate + sulfate"}
{"X":18764,"RHEA_ID":15606,"compounds":"H2O + L-serine O-sulfate => H(+) + NH4(+) + pyruvate + sulfate"}
{"X":18765,"RHEA_ID":15607,"compounds":"H(+) + NH4(+) + pyruvate + sulfate => H2O + L-serine O-sulfate"}
{"X":18766,"RHEA_ID":15609,"DIRECTION":"UN","MASTER_ID":15609,"ec":"2.7.6.1","compounds":"ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)"}
{"X":18767,"RHEA_ID":15610,"compounds":"ATP + D-ribose 5-phosphate => 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)"}
{"X":18768,"RHEA_ID":15611,"compounds":"5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+) => ATP + D-ribose 5-phosphate"}
{"X":18769,"RHEA_ID":25530,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O"}
{"X":18770,"RHEA_ID":15613,"DIRECTION":"UN","MASTER_ID":15613,"ec":"1.3.1.76","compounds":"NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin"}
{"X":18771,"RHEA_ID":15614,"compounds":"NAD(+) + precorrin-2 => 2 H(+) + NADH + sirohydrochlorin"}
{"X":18772,"RHEA_ID":15615,"compounds":"2 H(+) + NADH + sirohydrochlorin => NAD(+) + precorrin-2"}
{"X":18773,"RHEA_ID":25534,"compounds":"diphosphate + ent-cassa-12,15-diene => ent-copalyl diphosphate"}
{"X":18774,"RHEA_ID":15617,"DIRECTION":"UN","MASTER_ID":15617,"ec":"1.9.98.1","compounds":"[Fe(II)cytochrome c] + Fe(3+) = [Fe(III)cytochrome c] + Fe(2+)"}
{"X":18775,"RHEA_ID":15618,"compounds":"[Fe(II)cytochrome c] + Fe(3+) => [Fe(III)cytochrome c] + Fe(2+)"}
{"X":18776,"RHEA_ID":15619,"compounds":"[Fe(III)cytochrome c] + Fe(2+) => [Fe(II)cytochrome c] + Fe(3+)"}
{"X":18777,"RHEA_ID":15621,"DIRECTION":"UN","MASTER_ID":15621,"ec":"2.4.1.122","compounds":"an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP"}
{"X":18778,"RHEA_ID":15622,"DIRECTION":"LR","MASTER_ID":15621,"metacyc":"RXN-18266","compounds":"an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose => a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP"}
{"X":18779,"RHEA_ID":15623,"compounds":"a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP => an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose"}
{"X":18780,"RHEA_ID":15624,"compounds":"an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP"}
{"X":18781,"RHEA_ID":15625,"DIRECTION":"UN","MASTER_ID":15625,"ec":"1.3.1.106","compounds":"Co-precorrin-6B + NAD(+) = Co-precorrin-6A + H(+) + NADH"}
{"X":18782,"RHEA_ID":15626,"compounds":"Co-precorrin-6B + NAD(+) => Co-precorrin-6A + H(+) + NADH"}
{"X":18783,"RHEA_ID":15627,"DIRECTION":"RL","MASTER_ID":15625,"metacyc":"RXN-8765","compounds":"Co-precorrin-6A + H(+) + NADH => Co-precorrin-6B + NAD(+)"}
{"X":18784,"RHEA_ID":25546,"compounds":"diphosphate + ent-pimara-9(11),15-diene => ent-copalyl diphosphate"}
{"X":18785,"RHEA_ID":15629,"DIRECTION":"UN","MASTER_ID":15629,"ec":"1.14.15.4","compounds":"a steroid + 2 H(+) + O2 + 2 reduced [adrenodoxin] = an 11beta-hydroxysteroid + H2O + 2 oxidized [adrenodoxin]"}
{"X":18786,"RHEA_ID":15630,"DIRECTION":"LR","MASTER_ID":15629,"metacyc":"STEROID-11-BETA-MONOOXYGENASE-RXN","compounds":"a steroid + 2 H(+) + O2 + 2 reduced [adrenodoxin] => an 11beta-hydroxysteroid + H2O + 2 oxidized [adrenodoxin]"}
{"X":18787,"RHEA_ID":15631,"compounds":"an 11beta-hydroxysteroid + H2O + 2 oxidized [adrenodoxin] => a steroid + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}
{"X":18788,"RHEA_ID":15633,"DIRECTION":"UN","MASTER_ID":15633,"ec":"1.13.11.15","compounds":"3,4-dihydroxyphenylacetate + O2 = 2-hydroxy-5-carboxymethylmuconate semialdehyde + H(+)"}
{"X":18789,"RHEA_ID":15634,"DIRECTION":"LR","MASTER_ID":15633,"metacyc":"1.13.11.15-RXN","compounds":"3,4-dihydroxyphenylacetate + O2 => 2-hydroxy-5-carboxymethylmuconate semialdehyde + H(+)"}
{"X":18790,"RHEA_ID":15635,"compounds":"2-hydroxy-5-carboxymethylmuconate semialdehyde + H(+) => 3,4-dihydroxyphenylacetate + O2"}
{"X":18791,"RHEA_ID":25554,"compounds":"diphosphate + stemar-13-ene => 9alpha-copalyl diphosphate"}
{"X":18792,"RHEA_ID":15637,"compounds":"[alginate](n) + GDP-alpha-D-mannuronate = [alginate](n+1) + GDP + H(+)"}
{"X":18793,"RHEA_ID":15638,"compounds":"[alginate](n) + GDP-alpha-D-mannuronate => [alginate](n+1) + GDP + H(+)"}
{"X":18794,"RHEA_ID":15639,"compounds":"[alginate](n+1) + GDP + H(+) => [alginate](n) + GDP-alpha-D-mannuronate"}
{"X":18795,"RHEA_ID":25558,"compounds":"diphosphate + stemod-13(17)-ene => 9alpha-copalyl diphosphate"}
{"X":18796,"RHEA_ID":15641,"DIRECTION":"UN","MASTER_ID":15641,"ec":"1.1.1.38","compounds":"H(+) + oxaloacetate = CO2 + pyruvate"}
{"X":18797,"RHEA_ID":15641,"DIRECTION":"UN","MASTER_ID":15641,"ec":"1.1.1.40","compounds":"H(+) + oxaloacetate = CO2 + pyruvate"}
{"X":18798,"RHEA_ID":15641,"DIRECTION":"UN","MASTER_ID":15641,"ec":"4.1.1.112","compounds":"H(+) + oxaloacetate = CO2 + pyruvate"}
{"X":18799,"RHEA_ID":15642,"DIRECTION":"LR","MASTER_ID":15641,"ecocyc":"OXALODECARB-RXN","metacyc":"OXALODECARB-RXN","reactome":"R-HSA-9012016.1","compounds":"H(+) + oxaloacetate => CO2 + pyruvate"}
{"X":18800,"RHEA_ID":15643,"compounds":"CO2 + pyruvate => H(+) + oxaloacetate"}
{"X":18801,"RHEA_ID":15645,"DIRECTION":"UN","MASTER_ID":15645,"ec":"1.19.6.1","compounds":"16 ATP + 16 H2O + N2 + 4 reduced [flavodoxin] = 16 ADP + 18 H(+) + H2 + 2 NH4(+) + 4 oxidized [flavodoxin] + 16 phosphate"}
{"X":18802,"RHEA_ID":15646,"DIRECTION":"LR","MASTER_ID":15645,"metacyc":"NITROGENASE-FLAVODOXIN-RXN","compounds":"16 ATP + 16 H2O + N2 + 4 reduced [flavodoxin] => 16 ADP + 18 H(+) + H2 + 2 NH4(+) + 4 oxidized [flavodoxin] + 16 phosphate"}
{"X":18803,"RHEA_ID":15647,"compounds":"16 ADP + 18 H(+) + H2 + 2 NH4(+) + 4 oxidized [flavodoxin] + 16 phosphate => 16 ATP + 16 H2O + N2 + 4 reduced [flavodoxin]"}
{"X":18804,"RHEA_ID":25568,"DIRECTION":"UN","MASTER_ID":25568,"ec":"2.7.1.173","compounds":"ATP + beta-D-ribosylnicotinate = ADP + H(+) + nicotinate beta-D-ribonucleotide"}
{"X":18805,"RHEA_ID":15649,"compounds":"carbamate + 2 H(+) = CO2 + NH4(+)"}
{"X":18806,"RHEA_ID":15650,"DIRECTION":"LR","MASTER_ID":15649,"ecocyc":"RXN0-5222","metacyc":"RXN0-5222","compounds":"carbamate + 2 H(+) => CO2 + NH4(+)"}
{"X":18807,"RHEA_ID":15651,"compounds":"CO2 + NH4(+) => carbamate + 2 H(+)"}
{"X":18808,"RHEA_ID":15653,"DIRECTION":"UN","MASTER_ID":15653,"ec":"2.7.1.105","compounds":"ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate + H(+)"}
{"X":18809,"RHEA_ID":15654,"compounds":"ATP + beta-D-fructose 6-phosphate => ADP + beta-D-fructose 2,6-bisphosphate + H(+)"}
{"X":18810,"RHEA_ID":15655,"compounds":"ADP + beta-D-fructose 2,6-bisphosphate + H(+) => ATP + beta-D-fructose 6-phosphate"}
{"X":18811,"RHEA_ID":25575,"DIRECTION":"BI","MASTER_ID":25572,"metacyc":"RXN-9454","compounds":"geranylgeranyl diphosphate + 2 H2O <=> diphosphate + sclareol"}
{"X":18812,"RHEA_ID":15657,"DIRECTION":"UN","MASTER_ID":15657,"ec":"1.3.1.68","metacyc":"1.3.1.68-RXN","compounds":"1,6-dihydroxy-2-methylcyclohexa-2,4-dienecarboxylate + NAD(+) = 3-methylcatechol + CO2 + NADH"}
{"X":18813,"RHEA_ID":15658,"compounds":"1,6-dihydroxy-2-methylcyclohexa-2,4-dienecarboxylate + NAD(+) => 3-methylcatechol + CO2 + NADH"}
{"X":18814,"RHEA_ID":15659,"compounds":"3-methylcatechol + CO2 + NADH => 1,6-dihydroxy-2-methylcyclohexa-2,4-dienecarboxylate + NAD(+)"}
{"X":18815,"RHEA_ID":36141,"compounds":"(2E)-hexadecenoyl-CoA + AMP + diphosphate => (E)-hexadec-2-enoate + ATP + CoA"}
{"X":18816,"RHEA_ID":15661,"DIRECTION":"UN","MASTER_ID":15661,"ec":"2.3.1.153","metacyc":"RXN-7945","compounds":"(E)-4-coumaroyl-CoA + an anthocyanidin 3,5-di-O-beta-D-glucoside = an anthocyanidin 3-O-beta-D-glucoside 5-O-beta-D-[(6-O-(E)-4-coumaroyl)glucoside] + CoA"}
{"X":18817,"RHEA_ID":15662,"compounds":"(E)-4-coumaroyl-CoA + an anthocyanidin 3,5-di-O-beta-D-glucoside => an anthocyanidin 3-O-beta-D-glucoside 5-O-beta-D-[(6-O-(E)-4-coumaroyl)glucoside] + CoA"}
{"X":18818,"RHEA_ID":15663,"compounds":"an anthocyanidin 3-O-beta-D-glucoside 5-O-beta-D-[(6-O-(E)-4-coumaroyl)glucoside] + CoA => (E)-4-coumaroyl-CoA + an anthocyanidin 3,5-di-O-beta-D-glucoside"}
{"X":18819,"RHEA_ID":25583,"DIRECTION":"BI","MASTER_ID":25580,"ecocyc":"RXN0-5298","metacyc":"RXN0-5298","compounds":"alpha-L-fucose <=> beta-L-fucose"}
{"X":18820,"RHEA_ID":15665,"compounds":"aldehydo-D-glucose + L-lysyl-[protein] = H2O + N(6)-(D-fructosyl)-L-lysyl-[protein]"}
{"X":18821,"RHEA_ID":15666,"compounds":"aldehydo-D-glucose + L-lysyl-[protein] => H2O + N(6)-(D-fructosyl)-L-lysyl-[protein]"}
{"X":18822,"RHEA_ID":15667,"compounds":"H2O + N(6)-(D-fructosyl)-L-lysyl-[protein] => aldehydo-D-glucose + L-lysyl-[protein]"}
{"X":18823,"RHEA_ID":15668,"compounds":"aldehydo-D-glucose + L-lysyl-[protein] <=> H2O + N(6)-(D-fructosyl)-L-lysyl-[protein]"}
{"X":18824,"RHEA_ID":15669,"DIRECTION":"UN","MASTER_ID":15669,"ec":"2.7.1.78","compounds":"5'-dephospho-(DNA) + ATP = ADP + H(+) + phospho-5'-(DNA)"}
{"X":18825,"RHEA_ID":15670,"compounds":"5'-dephospho-(DNA) + ATP => ADP + H(+) + phospho-5'-(DNA)"}
{"X":18826,"RHEA_ID":15671,"compounds":"ADP + H(+) + phospho-5'-(DNA) => 5'-dephospho-(DNA) + ATP"}
{"X":18827,"RHEA_ID":36153,"compounds":"cinnamyl acetate + CoA => acetyl-CoA + cinnamyl alcohol"}
{"X":18828,"RHEA_ID":15673,"DIRECTION":"UN","MASTER_ID":15673,"ec":"3.1.2.11","compounds":"acetoacetyl-CoA + H2O = acetoacetate + CoA + H(+)"}
{"X":18829,"RHEA_ID":15674,"DIRECTION":"LR","MASTER_ID":15673,"metacyc":"ACETOACETYL-COA-HYDROLASE-RXN","compounds":"acetoacetyl-CoA + H2O => acetoacetate + CoA + H(+)"}
{"X":18830,"RHEA_ID":15675,"compounds":"acetoacetate + CoA + H(+) => acetoacetyl-CoA + H2O"}
{"X":18831,"RHEA_ID":36157,"compounds":"A + Co-precorrin-4 + S-adenosyl-L-homocysteine => AH2 + Co(II)-factor III + S-adenosyl-L-methionine"}
{"X":18832,"RHEA_ID":15677,"DIRECTION":"UN","MASTER_ID":15677,"ec":"3.5.1.30","compounds":"5-aminopentanamide + H2O = 5-aminopentanoate + NH4(+)"}
{"X":18833,"RHEA_ID":15678,"DIRECTION":"LR","MASTER_ID":15677,"metacyc":"5-AMINOPENTANAMIDASE-RXN","compounds":"5-aminopentanamide + H2O => 5-aminopentanoate + NH4(+)"}
{"X":18834,"RHEA_ID":15679,"compounds":"5-aminopentanoate + NH4(+) => 5-aminopentanamide + H2O"}
{"X":18835,"RHEA_ID":36161,"DIRECTION":"RL","MASTER_ID":36159,"metacyc":"RXN-14399","compounds":"2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate + 16 H(+) + 16 reduced [2Fe-2S]-[ferredoxin] => 2,3-bis-(O-phytanyl)-sn-glycerol 1-phosphate + 16 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":18836,"RHEA_ID":15681,"DIRECTION":"UN","MASTER_ID":15681,"ec":"1.2.1.60","compounds":"2-hydroxy-5-carboxymethylmuconate semialdehyde + H2O + NAD(+) = (2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate + 2 H(+) + NADH"}
{"X":18837,"RHEA_ID":15682,"DIRECTION":"LR","MASTER_ID":15681,"metacyc":"CHMS-DEHYDROGENASE-RXN","compounds":"2-hydroxy-5-carboxymethylmuconate semialdehyde + H2O + NAD(+) => (2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate + 2 H(+) + NADH"}
{"X":18838,"RHEA_ID":15683,"compounds":"(2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate + 2 H(+) + NADH => 2-hydroxy-5-carboxymethylmuconate semialdehyde + H2O + NAD(+)"}
{"X":18839,"RHEA_ID":36165,"compounds":"ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate => 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate"}
{"X":18840,"RHEA_ID":15689,"DIRECTION":"UN","MASTER_ID":15689,"ec":"4.1.1.86","compounds":"H(+) + L-2,4-diaminobutanoate = CO2 + propane-1,3-diamine"}
{"X":18841,"RHEA_ID":15690,"DIRECTION":"LR","MASTER_ID":15689,"metacyc":"4.1.1.86-RXN","compounds":"H(+) + L-2,4-diaminobutanoate => CO2 + propane-1,3-diamine"}
{"X":18842,"RHEA_ID":15691,"compounds":"CO2 + propane-1,3-diamine => H(+) + L-2,4-diaminobutanoate"}
{"X":18843,"RHEA_ID":15693,"compounds":"(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + AH2 = (R)-2-hydroxy-(9Z,12Z,15Z)-octadecatrienoate + A + H2O"}
{"X":18844,"RHEA_ID":15694,"compounds":"(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + AH2 => (R)-2-hydroxy-(9Z,12Z,15Z)-octadecatrienoate + A + H2O"}
{"X":18845,"RHEA_ID":15695,"compounds":"(R)-2-hydroxy-(9Z,12Z,15Z)-octadecatrienoate + A + H2O => (R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + AH2"}
{"X":18846,"RHEA_ID":15696,"compounds":"(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + AH2 <=> (R)-2-hydroxy-(9Z,12Z,15Z)-octadecatrienoate + A + H2O"}
{"X":18847,"RHEA_ID":15697,"DIRECTION":"UN","MASTER_ID":15697,"ec":"1.14.14.140","compounds":"liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + licodione + oxidized [NADPH--hemoprotein reductase]"}
{"X":18848,"RHEA_ID":15698,"DIRECTION":"LR","MASTER_ID":15697,"metacyc":"1.14.13.87-RXN","compounds":"liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + licodione + oxidized [NADPH--hemoprotein reductase]"}
{"X":18849,"RHEA_ID":15699,"compounds":"2 H(+) + H2O + licodione + oxidized [NADPH--hemoprotein reductase] => liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":18850,"RHEA_ID":36177,"compounds":"1-O-alkyl-sn-glycero-3-phosphate + NADP(+) => 1-O-alkylglycerone 3-phosphate + H(+) + NADPH"}
{"X":18851,"RHEA_ID":15701,"compounds":"AH2 + all-trans-neurosporene + O2 = A + all-trans-lycopene + 2 H2O"}
{"X":18852,"RHEA_ID":15702,"DIRECTION":"LR","MASTER_ID":15701,"metacyc":"1.14.99.30-RXN","compounds":"AH2 + all-trans-neurosporene + O2 => A + all-trans-lycopene + 2 H2O"}
{"X":18853,"RHEA_ID":15703,"compounds":"A + all-trans-lycopene + 2 H2O => AH2 + all-trans-neurosporene + O2"}
{"X":18854,"RHEA_ID":36181,"compounds":"1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+) => 1-O-alkyl-2-acyl-sn-glycerol + CDP-choline"}
{"X":18855,"RHEA_ID":15705,"DIRECTION":"UN","MASTER_ID":15705,"ec":"1.17.5.1","compounds":"2 a ubiquinone + H2O + phenylacetyl-CoA = 2 a ubiquinol + phenylglyoxylyl-CoA"}
{"X":18856,"RHEA_ID":15706,"DIRECTION":"LR","MASTER_ID":15705,"metacyc":"1.17.5.1-RXN","compounds":"2 a ubiquinone + H2O + phenylacetyl-CoA => 2 a ubiquinol + phenylglyoxylyl-CoA"}
{"X":18857,"RHEA_ID":15707,"compounds":"2 a ubiquinol + phenylglyoxylyl-CoA => 2 a ubiquinone + H2O + phenylacetyl-CoA"}
{"X":18858,"RHEA_ID":36185,"compounds":"1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+) => a 1-O-alkyl-2-acetyl-sn-glycerol + CDP-choline"}
{"X":18859,"RHEA_ID":15709,"DIRECTION":"UN","MASTER_ID":15709,"ec":"2.4.1.234","compounds":"kaempferol + UDP-alpha-D-galactose = H(+) + kaempferol 3-O-beta-D-galactoside + UDP"}
{"X":18860,"RHEA_ID":15710,"compounds":"kaempferol + UDP-alpha-D-galactose => H(+) + kaempferol 3-O-beta-D-galactoside + UDP"}
{"X":18861,"RHEA_ID":15711,"compounds":"H(+) + kaempferol 3-O-beta-D-galactoside + UDP => kaempferol + UDP-alpha-D-galactose"}
{"X":18862,"RHEA_ID":36189,"compounds":"1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+) => 1-O-alkyl-2-acyl-sn-glycerol + CDP-ethanolamine"}
{"X":18863,"RHEA_ID":15713,"DIRECTION":"UN","MASTER_ID":15713,"ec":"2.3.1.18","compounds":"a beta-D-galactoside + acetyl-CoA = a 6-acetyl-beta-D-galactoside + CoA"}
{"X":18864,"RHEA_ID":15714,"compounds":"a beta-D-galactoside + acetyl-CoA => a 6-acetyl-beta-D-galactoside + CoA"}
{"X":18865,"RHEA_ID":15715,"compounds":"a 6-acetyl-beta-D-galactoside + CoA => a beta-D-galactoside + acetyl-CoA"}
{"X":18866,"RHEA_ID":36193,"compounds":"1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + ethanolamine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + choline"}
{"X":18867,"RHEA_ID":15717,"DIRECTION":"UN","MASTER_ID":15717,"ec":"1.14.13.181","compounds":"daunorubicin + H(+) + NADPH + O2 = doxorubicin + H2O + NADP(+)"}
{"X":18868,"RHEA_ID":15718,"DIRECTION":"LR","MASTER_ID":15717,"metacyc":"RXN-14855","compounds":"daunorubicin + H(+) + NADPH + O2 => doxorubicin + H2O + NADP(+)"}
{"X":18869,"RHEA_ID":15719,"compounds":"doxorubicin + H2O + NADP(+) => daunorubicin + H(+) + NADPH + O2"}
{"X":18870,"RHEA_ID":36197,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + a carboxylate + H(+) => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O"}
{"X":18871,"RHEA_ID":15721,"DIRECTION":"UN","MASTER_ID":15721,"ec":"1.4.1.10","compounds":"glycine + H2O + NAD(+) = glyoxylate + H(+) + NADH + NH4(+)"}
{"X":18872,"RHEA_ID":15722,"compounds":"glycine + H2O + NAD(+) => glyoxylate + H(+) + NADH + NH4(+)"}
{"X":18873,"RHEA_ID":15723,"compounds":"glyoxylate + H(+) + NADH + NH4(+) => glycine + H2O + NAD(+)"}
{"X":18874,"RHEA_ID":15725,"DIRECTION":"UN","MASTER_ID":15725,"ec":"4.2.1.111","compounds":"1,5-anhydro-D-fructose = ascopyrone M + H2O"}
{"X":18875,"RHEA_ID":15726,"DIRECTION":"LR","MASTER_ID":15725,"metacyc":"4.2.1.111-RXN","compounds":"1,5-anhydro-D-fructose => ascopyrone M + H2O"}
{"X":18876,"RHEA_ID":15727,"compounds":"ascopyrone M + H2O => 1,5-anhydro-D-fructose"}
{"X":18877,"RHEA_ID":36205,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + ethanolamine + H(+) => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O"}
{"X":18878,"RHEA_ID":15729,"DIRECTION":"UN","MASTER_ID":15729,"ec":"1.1.1.57","compounds":"D-mannonate + NAD(+) = H(+) + keto-D-fructuronate + NADH"}
{"X":18879,"RHEA_ID":15730,"compounds":"D-mannonate + NAD(+) => H(+) + keto-D-fructuronate + NADH"}
{"X":18880,"RHEA_ID":15731,"compounds":"H(+) + keto-D-fructuronate + NADH => D-mannonate + NAD(+)"}
{"X":18881,"RHEA_ID":36209,"compounds":"1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an acyl-CoA"}
{"X":18882,"RHEA_ID":15733,"DIRECTION":"UN","MASTER_ID":15733,"ec":"1.17.99.3","compounds":"(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + A + H2O = (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + AH2"}
{"X":18883,"RHEA_ID":15734,"compounds":"(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + A + H2O => (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + AH2"}
{"X":18884,"RHEA_ID":15735,"compounds":"(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + AH2 => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + A + H2O"}
{"X":18885,"RHEA_ID":15737,"DIRECTION":"UN","MASTER_ID":15737,"ec":"1.14.13.16","compounds":"cyclopentanone + H(+) + NADPH + O2 = 5-valerolactone + H2O + NADP(+)"}
{"X":18886,"RHEA_ID":15738,"DIRECTION":"LR","MASTER_ID":15737,"metacyc":"CYCLOPENTANONE-MONOOXYGENASE-RXN","compounds":"cyclopentanone + H(+) + NADPH + O2 => 5-valerolactone + H2O + NADP(+)"}
{"X":18887,"RHEA_ID":15739,"compounds":"5-valerolactone + H2O + NADP(+) => cyclopentanone + H(+) + NADPH + O2"}
{"X":18888,"RHEA_ID":15741,"compounds":"2,5-dichlorocyclohexa-2,5-dien-1,4-diol + NAD(+) = 2,5-dichlorohydroquinone + H(+) + NADH"}
{"X":18889,"RHEA_ID":15742,"compounds":"2,5-dichlorocyclohexa-2,5-dien-1,4-diol + NAD(+) => 2,5-dichlorohydroquinone + H(+) + NADH"}
{"X":18890,"RHEA_ID":15743,"compounds":"2,5-dichlorohydroquinone + H(+) + NADH => 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + NAD(+)"}
{"X":18891,"RHEA_ID":15744,"DIRECTION":"BI","MASTER_ID":15741,"metacyc":"LINC-RXN","compounds":"2,5-dichlorocyclohexa-2,5-dien-1,4-diol + NAD(+) <=> 2,5-dichlorohydroquinone + H(+) + NADH"}
{"X":18892,"RHEA_ID":15745,"DIRECTION":"UN","MASTER_ID":15745,"ec":"2.4.1.9","compounds":"[(2->1)-beta-D-fructosyl](n) + sucrose = [(2->1)-beta-D-fructosyl](n+1) + D-glucose"}
{"X":18893,"RHEA_ID":15746,"compounds":"[(2->1)-beta-D-fructosyl](n) + sucrose => [(2->1)-beta-D-fructosyl](n+1) + D-glucose"}
{"X":18894,"RHEA_ID":15747,"compounds":"[(2->1)-beta-D-fructosyl](n+1) + D-glucose => [(2->1)-beta-D-fructosyl](n) + sucrose"}
{"X":18895,"RHEA_ID":36225,"compounds":"1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + H(+) + phosphoethanolamine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O"}
{"X":18896,"RHEA_ID":15749,"DIRECTION":"UN","MASTER_ID":15749,"ec":"1.1.99.31","compounds":"(S)-mandelate + A = AH2 + phenylglyoxylate"}
{"X":18897,"RHEA_ID":15750,"DIRECTION":"LR","MASTER_ID":15749,"metacyc":"MANDELATE-DEHYDROGENASE-RXN","compounds":"(S)-mandelate + A => AH2 + phenylglyoxylate"}
{"X":18898,"RHEA_ID":15751,"compounds":"AH2 + phenylglyoxylate => (S)-mandelate + A"}
{"X":18899,"RHEA_ID":36229,"compounds":"1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+) => 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-choline"}
{"X":18900,"RHEA_ID":15753,"DIRECTION":"UN","MASTER_ID":15753,"ec":"6.3.4.4","compounds":"GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate"}
{"X":18901,"RHEA_ID":15754,"DIRECTION":"LR","MASTER_ID":15753,"ecocyc":"ADENYLOSUCCINATE-SYNTHASE-RXN","macie":"M0065","metacyc":"ADENYLOSUCCINATE-SYNTHASE-RXN","reactome":"R-HSA-111524.4","compounds":"GTP + IMP + L-aspartate => GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate"}
{"X":18902,"RHEA_ID":15755,"compounds":"GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate => GTP + IMP + L-aspartate"}
{"X":18903,"RHEA_ID":25673,"compounds":"sucrose + UDP-alpha-D-galactose <=> H(+) + loliose + UDP"}
{"X":18904,"RHEA_ID":15757,"DIRECTION":"UN","MASTER_ID":15757,"ec":"1.1.1.3","compounds":"L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH"}
{"X":18905,"RHEA_ID":15758,"compounds":"L-homoserine + NAD(+) => H(+) + L-aspartate 4-semialdehyde + NADH"}
{"X":18906,"RHEA_ID":15759,"DIRECTION":"RL","MASTER_ID":15757,"ecocyc":"HOMOSERDEHYDROG-RXN","metacyc":"HOMOSERDEHYDROG-RXN","compounds":"H(+) + L-aspartate 4-semialdehyde + NADH => L-homoserine + NAD(+)"}
{"X":18907,"RHEA_ID":15761,"DIRECTION":"UN","MASTER_ID":15761,"ec":"1.1.1.3","compounds":"L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH"}
{"X":18908,"RHEA_ID":15762,"compounds":"L-homoserine + NADP(+) => H(+) + L-aspartate 4-semialdehyde + NADPH"}
{"X":18909,"RHEA_ID":15763,"DIRECTION":"RL","MASTER_ID":15761,"ecocyc":"HOMOSERDEHYDROG-RXN","metacyc":"HOMOSERDEHYDROG-RXN","compounds":"H(+) + L-aspartate 4-semialdehyde + NADPH => L-homoserine + NADP(+)"}
{"X":18910,"RHEA_ID":36241,"compounds":"1-O-alkyl-2-acyl-sn-glycerol + phosphate => 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O"}
{"X":18911,"RHEA_ID":15765,"DIRECTION":"UN","MASTER_ID":15765,"ec":"2.7.1.156","compounds":"adenosylcob(III)inamide + GTP = adenosylcob(III)inamide phosphate + GDP + H(+)"}
{"X":18912,"RHEA_ID":15766,"DIRECTION":"LR","MASTER_ID":15765,"metacyc":"RXN-14063","compounds":"adenosylcob(III)inamide + GTP => adenosylcob(III)inamide phosphate + GDP + H(+)"}
{"X":18913,"RHEA_ID":15767,"compounds":"adenosylcob(III)inamide phosphate + GDP + H(+) => adenosylcob(III)inamide + GTP"}
{"X":18914,"RHEA_ID":25685,"compounds":"L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase]"}
{"X":18915,"RHEA_ID":15769,"DIRECTION":"UN","MASTER_ID":15769,"ec":"2.7.1.156","compounds":"adenosylcob(III)inamide + ATP = adenosylcob(III)inamide phosphate + ADP + H(+)"}
{"X":18916,"RHEA_ID":15770,"DIRECTION":"LR","MASTER_ID":15769,"ecocyc":"COBINAMIDEKIN-RXN","metacyc":"COBINAMIDEKIN-RXN","compounds":"adenosylcob(III)inamide + ATP => adenosylcob(III)inamide phosphate + ADP + H(+)"}
{"X":18917,"RHEA_ID":15771,"compounds":"adenosylcob(III)inamide phosphate + ADP + H(+) => adenosylcob(III)inamide + ATP"}
{"X":18918,"RHEA_ID":15773,"DIRECTION":"UN","MASTER_ID":15773,"ec":"2.7.1.29","compounds":"ATP + dihydroxyacetone = ADP + dihydroxyacetone phosphate + H(+)"}
{"X":18919,"RHEA_ID":15774,"DIRECTION":"LR","MASTER_ID":15773,"metacyc":"GLYCERONE-KINASE-RXN","compounds":"ATP + dihydroxyacetone => ADP + dihydroxyacetone phosphate + H(+)"}
{"X":18920,"RHEA_ID":15775,"compounds":"ADP + dihydroxyacetone phosphate + H(+) => ATP + dihydroxyacetone"}
{"X":18921,"RHEA_ID":15777,"DIRECTION":"UN","MASTER_ID":15777,"ec":"3.1.3.40","compounds":"1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O = 1-guanidino-1-deoxy-scyllo-inositol + phosphate"}
{"X":18922,"RHEA_ID":15778,"DIRECTION":"LR","MASTER_ID":15777,"metacyc":"3.1.3.40-RXN","compounds":"1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O => 1-guanidino-1-deoxy-scyllo-inositol + phosphate"}
{"X":18923,"RHEA_ID":15779,"compounds":"1-guanidino-1-deoxy-scyllo-inositol + phosphate => 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O"}
{"X":18924,"RHEA_ID":36257,"compounds":"(6R)-L-erythro-6,7-dihydrobiopterin + a 1-(1-hydroxyalkyl)-sn-glycerol + H2O => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 1-O-(1,2-saturated-alkyl)-sn-glycerol + O2"}
{"X":18925,"RHEA_ID":15781,"DIRECTION":"UN","MASTER_ID":15781,"ec":"5.4.3.6","compounds":"L-tyrosine = 3-amino-3-(4-hydroxyphenyl)propanoate"}
{"X":18926,"RHEA_ID":15782,"DIRECTION":"LR","MASTER_ID":15781,"macie":"M0245","compounds":"L-tyrosine => 3-amino-3-(4-hydroxyphenyl)propanoate"}
{"X":18927,"RHEA_ID":15783,"compounds":"3-amino-3-(4-hydroxyphenyl)propanoate => L-tyrosine"}
{"X":18928,"RHEA_ID":25701,"compounds":"H(+) + N,N-dihydroxy-L-hexahomomethionine <=> (E)-9-(methylsulfanyl)nonanal oxime + CO2 + H2O"}
{"X":18929,"RHEA_ID":15785,"compounds":"2 6-iminocyclohexa-2,4-dienone + A = 2-aminophenoxazin-3-one + AH2"}
{"X":18930,"RHEA_ID":15786,"compounds":"2 6-iminocyclohexa-2,4-dienone + A => 2-aminophenoxazin-3-one + AH2"}
{"X":18931,"RHEA_ID":15787,"compounds":"2-aminophenoxazin-3-one + AH2 => 2 6-iminocyclohexa-2,4-dienone + A"}
{"X":18932,"RHEA_ID":25705,"compounds":"N-hydroxy-L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase]"}
{"X":18933,"RHEA_ID":15789,"DIRECTION":"UN","MASTER_ID":15789,"ec":"1.1.1.113","metacyc":"L-XYLOSE-1-DEHYDROGENASE-RXN","compounds":"L-xylose + NADP(+) = H(+) + L-xylono-1,4-lactone + NADPH"}
{"X":18934,"RHEA_ID":15790,"compounds":"L-xylose + NADP(+) => H(+) + L-xylono-1,4-lactone + NADPH"}
{"X":18935,"RHEA_ID":15791,"compounds":"H(+) + L-xylono-1,4-lactone + NADPH => L-xylose + NADP(+)"}
{"X":18936,"RHEA_ID":25709,"compounds":"H(+) + N,N-dihydroxy-L-dihomomethionine <=> (E)-5-(methylsulfanyl)pentanal oxime + CO2 + H2O"}
{"X":18937,"RHEA_ID":15793,"DIRECTION":"UN","MASTER_ID":15793,"ec":"1.3.1.24","compounds":"bilirubin IXalpha + NADP(+) = biliverdin IXalpha + H(+) + NADPH"}
{"X":18938,"RHEA_ID":15794,"DIRECTION":"LR","MASTER_ID":15793,"metacyc":"BILIVERDIN-REDUCTASE-RXN","compounds":"bilirubin IXalpha + NADP(+) => biliverdin IXalpha + H(+) + NADPH"}
{"X":18939,"RHEA_ID":15795,"DIRECTION":"RL","MASTER_ID":15793,"metacyc":"BILIVERDIN-REDUCTASE-RXN","reactome":"R-HSA-189384.4","compounds":"biliverdin IXalpha + H(+) + NADPH => bilirubin IXalpha + NADP(+)"}
{"X":18940,"RHEA_ID":25714,"compounds":"L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase]"}
{"X":18941,"RHEA_ID":15797,"DIRECTION":"UN","MASTER_ID":15797,"ec":"1.3.1.24","compounds":"bilirubin IXalpha + NAD(+) = biliverdin IXalpha + H(+) + NADH"}
{"X":18942,"RHEA_ID":15798,"DIRECTION":"LR","MASTER_ID":15797,"metacyc":"BILIVERDIN-REDUCTASE-RXN","compounds":"bilirubin IXalpha + NAD(+) => biliverdin IXalpha + H(+) + NADH"}
{"X":18943,"RHEA_ID":15799,"compounds":"biliverdin IXalpha + H(+) + NADH => bilirubin IXalpha + NAD(+)"}
{"X":18944,"RHEA_ID":25718,"compounds":"N-hydroxy-L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase]"}
{"X":18945,"RHEA_ID":15801,"DIRECTION":"UN","MASTER_ID":15801,"ec":"3.1.1.4","compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)"}
{"X":18946,"RHEA_ID":15802,"DIRECTION":"LR","MASTER_ID":15801,"metacyc":"PHOSPHOLIPASE-A2-RXN","compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O => a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)"}
{"X":18947,"RHEA_ID":15803,"compounds":"a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O"}
{"X":18948,"RHEA_ID":15805,"DIRECTION":"UN","MASTER_ID":15805,"ec":"6.3.3.3","compounds":"7,8-diaminononanoate + ATP + CO2 = ADP + dethiobiotin + 3 H(+) + phosphate"}
{"X":18949,"RHEA_ID":15806,"DIRECTION":"LR","MASTER_ID":15805,"ecocyc":"DETHIOBIOTIN-SYN-RXN","macie":"M0074","metacyc":"DETHIOBIOTIN-SYN-RXN","compounds":"7,8-diaminononanoate + ATP + CO2 => ADP + dethiobiotin + 3 H(+) + phosphate"}
{"X":18950,"RHEA_ID":15807,"compounds":"ADP + dethiobiotin + 3 H(+) + phosphate => 7,8-diaminononanoate + ATP + CO2"}
{"X":18951,"RHEA_ID":25726,"compounds":"L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase]"}
{"X":18952,"RHEA_ID":15809,"DIRECTION":"UN","MASTER_ID":15809,"ec":"4.2.3.26","compounds":"(2E)-geranyl diphosphate + H2O = (R)-linalool + diphosphate"}
{"X":18953,"RHEA_ID":15810,"DIRECTION":"LR","MASTER_ID":15809,"metacyc":"4.2.3.26-RXN","compounds":"(2E)-geranyl diphosphate + H2O => (R)-linalool + diphosphate"}
{"X":18954,"RHEA_ID":15811,"compounds":"(R)-linalool + diphosphate => (2E)-geranyl diphosphate + H2O"}
{"X":18955,"RHEA_ID":25730,"compounds":"N-hydroxy-L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase]"}
{"X":18956,"RHEA_ID":15813,"DIRECTION":"UN","MASTER_ID":15813,"ec":"2.3.1.2","metacyc":"IMIDAZOLE-N-ACETYLTRANSFERASE-RXN","compounds":"1H-imidazole + acetyl-CoA = CoA + N-acetylimidazole"}
{"X":18957,"RHEA_ID":15814,"compounds":"1H-imidazole + acetyl-CoA => CoA + N-acetylimidazole"}
{"X":18958,"RHEA_ID":15815,"compounds":"CoA + N-acetylimidazole => 1H-imidazole + acetyl-CoA"}
{"X":18959,"RHEA_ID":25734,"compounds":"H(+) + N,N-dihydroxy-L-tetrahomomethionine <=> (E)-7-(methylsulfanyl)heptanal oxime + CO2 + H2O"}
{"X":18960,"RHEA_ID":15817,"DIRECTION":"UN","MASTER_ID":15817,"ec":"1.4.3.5","compounds":"H2O + O2 + pyridoxamine 5'-phosphate = H2O2 + NH4(+) + pyridoxal 5'-phosphate"}
{"X":18961,"RHEA_ID":15818,"DIRECTION":"LR","MASTER_ID":15817,"ecocyc":"PMPOXI-RXN","metacyc":"PMPOXI-RXN","reactome":"R-HSA-965079.1","compounds":"H2O + O2 + pyridoxamine 5'-phosphate => H2O2 + NH4(+) + pyridoxal 5'-phosphate"}
{"X":18962,"RHEA_ID":15819,"compounds":"H2O2 + NH4(+) + pyridoxal 5'-phosphate => H2O + O2 + pyridoxamine 5'-phosphate"}
{"X":18963,"RHEA_ID":25738,"compounds":"L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase]"}
{"X":18964,"RHEA_ID":15821,"DIRECTION":"UN","MASTER_ID":15821,"ec":"1.4.99.5","compounds":"2 A + glycine = 2 AH2 + CO2 + hydrogen cyanide"}
{"X":18965,"RHEA_ID":15822,"compounds":"2 A + glycine => 2 AH2 + CO2 + hydrogen cyanide"}
{"X":18966,"RHEA_ID":15823,"compounds":"2 AH2 + CO2 + hydrogen cyanide => 2 A + glycine"}
{"X":18967,"RHEA_ID":15825,"DIRECTION":"UN","MASTER_ID":15825,"ec":"3.3.2.9","compounds":"AZD1979 + H2O = AZD1979 oxetane hydrolysis product + H(+)"}
{"X":18968,"RHEA_ID":15826,"DIRECTION":"LR","MASTER_ID":15825,"metacyc":"RXN-18936","compounds":"AZD1979 + H2O => AZD1979 oxetane hydrolysis product + H(+)"}
{"X":18969,"RHEA_ID":15827,"compounds":"AZD1979 oxetane hydrolysis product + H(+) => AZD1979 + H2O"}
{"X":18970,"RHEA_ID":15828,"compounds":"AZD1979 + H2O <=> AZD1979 oxetane hydrolysis product + H(+)"}
{"X":18971,"RHEA_ID":15829,"DIRECTION":"UN","MASTER_ID":15829,"ec":"5.1.99.2","metacyc":"16-HYDROXYSTEROID-EPIMERASE-RXN","compounds":"a 16alpha-hydroxysteroid = a 16beta-hydroxysteroid"}
{"X":18972,"RHEA_ID":15830,"compounds":"a 16alpha-hydroxysteroid => a 16beta-hydroxysteroid"}
{"X":18973,"RHEA_ID":15831,"compounds":"a 16beta-hydroxysteroid => a 16alpha-hydroxysteroid"}
{"X":18974,"RHEA_ID":25750,"compounds":"L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase]"}
{"X":18975,"RHEA_ID":15833,"DIRECTION":"UN","MASTER_ID":15833,"ec":"1.1.3.19","compounds":"(S)-4-hydroxymandelate + H(+) + O2 = 4-hydroxybenzaldehyde + CO2 + H2O2"}
{"X":18976,"RHEA_ID":15834,"DIRECTION":"LR","MASTER_ID":15833,"metacyc":"4-HYDROXYMANDELATE-OXIDASE-RXN","compounds":"(S)-4-hydroxymandelate + H(+) + O2 => 4-hydroxybenzaldehyde + CO2 + H2O2"}
{"X":18977,"RHEA_ID":15835,"compounds":"4-hydroxybenzaldehyde + CO2 + H2O2 => (S)-4-hydroxymandelate + H(+) + O2"}
{"X":18978,"RHEA_ID":25754,"compounds":"N-hydroxy-L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase]"}
{"X":18979,"RHEA_ID":15837,"DIRECTION":"UN","MASTER_ID":15837,"ec":"2.1.1.21","metacyc":"2.1.1.21-RXN","compounds":"L-glutamate + methylamine = N-methyl-L-glutamate + NH4(+)"}
{"X":18980,"RHEA_ID":15838,"compounds":"L-glutamate + methylamine => N-methyl-L-glutamate + NH4(+)"}
{"X":18981,"RHEA_ID":15839,"compounds":"N-methyl-L-glutamate + NH4(+) => L-glutamate + methylamine"}
{"X":18982,"RHEA_ID":36316,"DIRECTION":"LR","MASTER_ID":36315,"metacyc":"RXN-17743","reactome":"R-HSA-390438.3","compounds":"2 H(+) + hexadecanoyl-CoA + 2 NADPH => CoA + hexadecan-1-ol + 2 NADP(+)"}
{"X":18983,"RHEA_ID":15841,"DIRECTION":"UN","MASTER_ID":15841,"ec":"1.1.1.49","metacyc":"RXN-14819","compounds":"D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH"}
{"X":18984,"RHEA_ID":15841,"DIRECTION":"UN","MASTER_ID":15841,"ec":"1.1.1.363","metacyc":"RXN-14819","compounds":"D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH"}
{"X":18985,"RHEA_ID":15842,"DIRECTION":"LR","MASTER_ID":15841,"ecocyc":"GLU6PDEHYDROG-RXN","metacyc":"GLU6PDEHYDROG-RXN","compounds":"D-glucose 6-phosphate + NADP(+) => 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH"}
{"X":18986,"RHEA_ID":15843,"compounds":"6-phospho-D-glucono-1,5-lactone + H(+) + NADPH => D-glucose 6-phosphate + NADP(+)"}
{"X":18987,"RHEA_ID":25767,"DIRECTION":"UN","MASTER_ID":25767,"ec":"1.1.1.n5","compounds":"3-carboxy-2-oxobutanoate + H(+) = 2-oxobutanoate + CO2"}
{"X":18988,"RHEA_ID":15845,"DIRECTION":"UN","MASTER_ID":15845,"ec":"2.4.1.52","compounds":"4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n UDP-alpha-D-glucose = 4-O-{[(2R)-2-alpha-D-glucosyl-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n H(+) + n UDP"}
{"X":18989,"RHEA_ID":15846,"DIRECTION":"LR","MASTER_ID":15845,"metacyc":"TEICHOICSYN5-RXN","compounds":"4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n UDP-alpha-D-glucose => 4-O-{[(2R)-2-alpha-D-glucosyl-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n H(+) + n UDP"}
{"X":18990,"RHEA_ID":15847,"compounds":"4-O-{[(2R)-2-alpha-D-glucosyl-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n H(+) + n UDP => 4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n UDP-alpha-D-glucose"}
{"X":18991,"RHEA_ID":25772,"DIRECTION":"UN","MASTER_ID":25772,"ec":"1.14.11.39","compounds":"2-oxoglutarate + L-asparagine + O2 = (2S,3S)-3-hydroxyasparagine + CO2 + succinate"}
{"X":18992,"RHEA_ID":15849,"compounds":"2 [Fe(III)cytochrome c] + L-ascorbate = 2 [Fe(II)cytochrome c] + 2 H(+) + L-dehydroascorbate"}
{"X":18993,"RHEA_ID":15850,"DIRECTION":"LR","MASTER_ID":15849,"metacyc":"RXN-12876","compounds":"2 [Fe(III)cytochrome c] + L-ascorbate => 2 [Fe(II)cytochrome c] + 2 H(+) + L-dehydroascorbate"}
{"X":18994,"RHEA_ID":15851,"compounds":"2 [Fe(II)cytochrome c] + 2 H(+) + L-dehydroascorbate => 2 [Fe(III)cytochrome c] + L-ascorbate"}
{"X":18995,"RHEA_ID":25776,"DIRECTION":"UN","MASTER_ID":25776,"ec":"5.3.99.11","compounds":"scyllo-inosose = scyllo-inosine"}
{"X":18996,"RHEA_ID":15853,"DIRECTION":"UN","MASTER_ID":15853,"ec":"1.1.1.149","compounds":"17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(+) = 17alpha-hydroxyprogesterone + H(+) + NADH"}
{"X":18997,"RHEA_ID":15854,"compounds":"17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(+) => 17alpha-hydroxyprogesterone + H(+) + NADH"}
{"X":18998,"RHEA_ID":15855,"compounds":"17alpha-hydroxyprogesterone + H(+) + NADH => 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(+)"}
{"X":18999,"RHEA_ID":15856,"DIRECTION":"BI","MASTER_ID":15853,"metacyc":"1.1.1.149-RXN","compounds":"17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(+) <=> 17alpha-hydroxyprogesterone + H(+) + NADH"}
{"X":19000,"RHEA_ID":15857,"DIRECTION":"UN","MASTER_ID":15857,"ec":"1.1.1.149","compounds":"17alpha,20alpha-dihydroxypregn-4-en-3-one + NADP(+) = 17alpha-hydroxyprogesterone + H(+) + NADPH"}
{"X":19001,"RHEA_ID":15858,"compounds":"17alpha,20alpha-dihydroxypregn-4-en-3-one + NADP(+) => 17alpha-hydroxyprogesterone + H(+) + NADPH"}
{"X":19002,"RHEA_ID":15859,"compounds":"17alpha-hydroxyprogesterone + H(+) + NADPH => 17alpha,20alpha-dihydroxypregn-4-en-3-one + NADP(+)"}
{"X":19003,"RHEA_ID":25784,"DIRECTION":"UN","MASTER_ID":25784,"ec":"4.1.2.53","compounds":"2-dehydro-3-deoxy-L-rhamnonate = (S)-lactaldehyde + pyruvate"}
{"X":19004,"RHEA_ID":15861,"DIRECTION":"UN","MASTER_ID":15861,"ec":"3.1.3.28","compounds":"3-ADP-2-phosphoglycerate + H2O = 3-ADP-glycerate + phosphate"}
{"X":19005,"RHEA_ID":15862,"DIRECTION":"LR","MASTER_ID":15861,"metacyc":"ADP-PHOSPHOGLYCERATE-PHOSPHATASE-RXN","compounds":"3-ADP-2-phosphoglycerate + H2O => 3-ADP-glycerate + phosphate"}
{"X":19006,"RHEA_ID":15863,"compounds":"3-ADP-glycerate + phosphate => 3-ADP-2-phosphoglycerate + H2O"}
{"X":19007,"RHEA_ID":25788,"DIRECTION":"UN","MASTER_ID":25788,"ec":"4.1.2.52","compounds":"4-hydroxy-2-oxoheptanedioate = pyruvate + succinate semialdehyde"}
{"X":19008,"RHEA_ID":15865,"DIRECTION":"UN","MASTER_ID":15865,"ec":"1.14.99.59","compounds":"AH2 + O2 + tryptamine = 4-hydroxytryptamine + A + H2O"}
{"X":19009,"RHEA_ID":15866,"DIRECTION":"LR","MASTER_ID":15865,"metacyc":"RXN-19089","compounds":"AH2 + O2 + tryptamine => 4-hydroxytryptamine + A + H2O"}
{"X":19010,"RHEA_ID":15867,"compounds":"4-hydroxytryptamine + A + H2O => AH2 + O2 + tryptamine"}
{"X":19011,"RHEA_ID":25792,"DIRECTION":"UN","MASTER_ID":25792,"ec":"7.2.2.8","compounds":"ATP + Cu(+)(in) + H2O = ADP + Cu(+)(out) + H(+) + phosphate"}
{"X":19012,"RHEA_ID":15869,"DIRECTION":"UN","MASTER_ID":15869,"ec":"2.6.1.21","compounds":"2-oxoglutarate + D-alanine = D-glutamate + pyruvate"}
{"X":19013,"RHEA_ID":15870,"compounds":"2-oxoglutarate + D-alanine => D-glutamate + pyruvate"}
{"X":19014,"RHEA_ID":15871,"DIRECTION":"RL","MASTER_ID":15869,"macie":"M0066","compounds":"D-glutamate + pyruvate => 2-oxoglutarate + D-alanine"}
{"X":19015,"RHEA_ID":25796,"DIRECTION":"UN","MASTER_ID":25796,"ec":"2.6.1.57","compounds":"2-oxoglutarate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + L-glutamate"}
{"X":19016,"RHEA_ID":15873,"DIRECTION":"UN","MASTER_ID":15873,"ec":"2.4.1.242","compounds":"[(1->4)-alpha-D-glucosyl](n) + an NDP-alpha-D-glucose = [(1->4)-alpha-D-glucosyl](n+1) + a ribonucleoside 5'-diphosphate + H(+)"}
{"X":19017,"RHEA_ID":15874,"compounds":"[(1->4)-alpha-D-glucosyl](n) + an NDP-alpha-D-glucose => [(1->4)-alpha-D-glucosyl](n+1) + a ribonucleoside 5'-diphosphate + H(+)"}
{"X":19018,"RHEA_ID":15875,"compounds":"[(1->4)-alpha-D-glucosyl](n+1) + a ribonucleoside 5'-diphosphate + H(+) => [(1->4)-alpha-D-glucosyl](n) + an NDP-alpha-D-glucose"}
{"X":19019,"RHEA_ID":15877,"DIRECTION":"UN","MASTER_ID":15877,"ec":"2.6.1.54","compounds":"2-oxoglutarate + pyridoxamine 5'-phosphate = D-glutamate + pyridoxal 5'-phosphate"}
{"X":19020,"RHEA_ID":15878,"compounds":"2-oxoglutarate + pyridoxamine 5'-phosphate => D-glutamate + pyridoxal 5'-phosphate"}
{"X":19021,"RHEA_ID":15879,"compounds":"D-glutamate + pyridoxal 5'-phosphate => 2-oxoglutarate + pyridoxamine 5'-phosphate"}
{"X":19022,"RHEA_ID":36357,"compounds":"4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine => 4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine"}
{"X":19023,"RHEA_ID":15881,"DIRECTION":"UN","MASTER_ID":15881,"ec":"2.7.11.8","compounds":"[Fas-activated protein]-L-serine + ATP = [Fas-activated protein]-O-phospho-L-serine + ADP + H(+)"}
{"X":19024,"RHEA_ID":15882,"compounds":"[Fas-activated protein]-L-serine + ATP => [Fas-activated protein]-O-phospho-L-serine + ADP + H(+)"}
{"X":19025,"RHEA_ID":15883,"compounds":"[Fas-activated protein]-O-phospho-L-serine + ADP + H(+) => [Fas-activated protein]-L-serine + ATP"}
{"X":19026,"RHEA_ID":15884,"DIRECTION":"BI","MASTER_ID":15881,"metacyc":"2.7.11.8-RXN","compounds":"[Fas-activated protein]-L-serine + ATP <=> [Fas-activated protein]-O-phospho-L-serine + ADP + H(+)"}
{"X":19027,"RHEA_ID":15885,"DIRECTION":"UN","MASTER_ID":15885,"ec":"1.1.1.55","compounds":"NADP(+) + propane-1,2-diol = (S)-lactaldehyde + H(+) + NADPH"}
{"X":19028,"RHEA_ID":15886,"compounds":"NADP(+) + propane-1,2-diol => (S)-lactaldehyde + H(+) + NADPH"}
{"X":19029,"RHEA_ID":15887,"DIRECTION":"RL","MASTER_ID":15885,"metacyc":"LACTALDEHYDE-REDUCTASE-NADPH-RXN","compounds":"(S)-lactaldehyde + H(+) + NADPH => NADP(+) + propane-1,2-diol"}
{"X":19030,"RHEA_ID":15889,"DIRECTION":"UN","MASTER_ID":15889,"ec":"3.5.1.2","compounds":"H2O + L-glutamine = L-glutamate + NH4(+)"}
{"X":19031,"RHEA_ID":15889,"DIRECTION":"UN","MASTER_ID":15889,"ec":"3.5.1.38","compounds":"H2O + L-glutamine = L-glutamate + NH4(+)"}
{"X":19032,"RHEA_ID":15890,"DIRECTION":"LR","MASTER_ID":15889,"ecocyc":"GLUTAMIN-RXN","macie":"M0301","metacyc":"GLUTAMIN-RXN","reactome":"R-HSA-70609.3","compounds":"H2O + L-glutamine => L-glutamate + NH4(+)"}
{"X":19033,"RHEA_ID":15891,"compounds":"L-glutamate + NH4(+) => H2O + L-glutamine"}
{"X":19034,"RHEA_ID":15893,"DIRECTION":"UN","MASTER_ID":15893,"ec":"4.99.1.3","compounds":"Co-sirohydrochlorin + 2 H(+) = Co(2+) + sirohydrochlorin"}
{"X":19035,"RHEA_ID":15894,"DIRECTION":"LR","MASTER_ID":15893,"metacyc":"4.99.1.3-RXN","compounds":"Co-sirohydrochlorin + 2 H(+) => Co(2+) + sirohydrochlorin"}
{"X":19036,"RHEA_ID":15895,"compounds":"Co(2+) + sirohydrochlorin => Co-sirohydrochlorin + 2 H(+)"}
{"X":19037,"RHEA_ID":25813,"DIRECTION":"LR","MASTER_ID":25812,"metacyc":"RXN-9942","reactome":"R-HSA-141348.1","compounds":"H2O + N(1)-acetylspermidine + O2 => 3-acetamidopropanal + H2O2 + putrescine"}
{"X":19038,"RHEA_ID":15897,"DIRECTION":"UN","MASTER_ID":15897,"ec":"3.5.1.63","compounds":"4-acetamidobutanoate + H2O = 4-aminobutanoate + acetate"}
{"X":19039,"RHEA_ID":15898,"DIRECTION":"LR","MASTER_ID":15897,"metacyc":"RXN-36","compounds":"4-acetamidobutanoate + H2O => 4-aminobutanoate + acetate"}
{"X":19040,"RHEA_ID":15899,"compounds":"4-aminobutanoate + acetate => 4-acetamidobutanoate + H2O"}
{"X":19041,"RHEA_ID":25817,"compounds":"H2O + norspermine + O2 => 3-aminopropanal + H2O2 + norspermidine"}
{"X":19042,"RHEA_ID":15901,"DIRECTION":"UN","MASTER_ID":15901,"ec":"5.4.2.11","compounds":"(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate"}
{"X":19043,"RHEA_ID":15901,"DIRECTION":"UN","MASTER_ID":15901,"ec":"5.4.2.12","compounds":"(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate"}
{"X":19044,"RHEA_ID":15902,"DIRECTION":"LR","MASTER_ID":15901,"reactome":"R-HSA-71445.3","compounds":"(2R)-2-phosphoglycerate => (2R)-3-phosphoglycerate"}
{"X":19045,"RHEA_ID":15903,"DIRECTION":"RL","MASTER_ID":15901,"reactome":"R-HSA-71654.3","compounds":"(2R)-3-phosphoglycerate => (2R)-2-phosphoglycerate"}
{"X":19046,"RHEA_ID":25822,"compounds":"4-aminobutanal + H2O2 + propane-1,3-diamine => H2O + O2 + spermidine"}
{"X":19047,"RHEA_ID":15905,"DIRECTION":"UN","MASTER_ID":15905,"ec":"1.1.99.26","metacyc":"3-HYDROXYCYCLOHEXANONE-DEHYDROGENASE-RXN","compounds":"3-hydroxycyclohexanone + A = AH2 + cyclohexane-1,3-dione"}
{"X":19048,"RHEA_ID":15906,"compounds":"3-hydroxycyclohexanone + A => AH2 + cyclohexane-1,3-dione"}
{"X":19049,"RHEA_ID":15907,"compounds":"AH2 + cyclohexane-1,3-dione => 3-hydroxycyclohexanone + A"}
{"X":19050,"RHEA_ID":25826,"compounds":"H2O2 + N-(3-aminopropyl)-4-aminobutanal + propane-1,3-diamine => H2O + O2 + spermine"}
{"X":19051,"RHEA_ID":15909,"DIRECTION":"UN","MASTER_ID":15909,"ec":"1.14.11.17","compounds":"2-oxoglutarate + O2 + taurine = aminoacetaldehyde + CO2 + H(+) + succinate + sulfite"}
{"X":19052,"RHEA_ID":15910,"DIRECTION":"LR","MASTER_ID":15909,"ecocyc":"RXN0-299","macie":"M0129","metacyc":"RXN0-299","compounds":"2-oxoglutarate + O2 + taurine => aminoacetaldehyde + CO2 + H(+) + succinate + sulfite"}
{"X":19053,"RHEA_ID":15911,"compounds":"aminoacetaldehyde + CO2 + H(+) + succinate + sulfite => 2-oxoglutarate + O2 + taurine"}
{"X":19054,"RHEA_ID":25830,"compounds":"A + a (4R,8E)-4-hydroxysphingenine ceramide + 2 H2O => AH2 + an N-acyl-(4R)-4-hydroxysphinganine + O2"}
{"X":19055,"RHEA_ID":15913,"DIRECTION":"UN","MASTER_ID":15913,"ec":"2.7.4.16","compounds":"ATP + thiamine phosphate = ADP + thiamine diphosphate"}
{"X":19056,"RHEA_ID":15914,"DIRECTION":"LR","MASTER_ID":15913,"ecocyc":"THI-P-KIN-RXN","metacyc":"THI-P-KIN-RXN","compounds":"ATP + thiamine phosphate => ADP + thiamine diphosphate"}
{"X":19057,"RHEA_ID":15915,"compounds":"ADP + thiamine diphosphate => ATP + thiamine phosphate"}
{"X":19058,"RHEA_ID":25834,"compounds":"H(+) + NADH + scyllo-inosine => 1D-chiro-inositol + NAD(+)"}
{"X":19059,"RHEA_ID":15917,"DIRECTION":"UN","MASTER_ID":15917,"ec":"1.1.1.359","metacyc":"ALDOSE-1-DEHYDROGENASE-RXN","compounds":"an aldopyranose + NAD(+) = aldono-1,5-lactone + H(+) + NADH"}
{"X":19060,"RHEA_ID":15917,"DIRECTION":"UN","MASTER_ID":15917,"ec":"1.1.1.359","metacyc":"RXN-14233","compounds":"an aldopyranose + NAD(+) = aldono-1,5-lactone + H(+) + NADH"}
{"X":19061,"RHEA_ID":15917,"DIRECTION":"UN","MASTER_ID":15917,"ec":"1.1.1.121","metacyc":"ALDOSE-1-DEHYDROGENASE-RXN","compounds":"an aldopyranose + NAD(+) = aldono-1,5-lactone + H(+) + NADH"}
{"X":19062,"RHEA_ID":15917,"DIRECTION":"UN","MASTER_ID":15917,"ec":"1.1.1.121","metacyc":"RXN-14233","compounds":"an aldopyranose + NAD(+) = aldono-1,5-lactone + H(+) + NADH"}
{"X":19063,"RHEA_ID":15918,"compounds":"an aldopyranose + NAD(+) => aldono-1,5-lactone + H(+) + NADH"}
{"X":19064,"RHEA_ID":15919,"compounds":"aldono-1,5-lactone + H(+) + NADH => an aldopyranose + NAD(+)"}
{"X":19065,"RHEA_ID":25841,"compounds":"5-deoxy-D-glucuronate => 5-dehydro-2-deoxy-D-gluconate"}
{"X":19066,"RHEA_ID":15921,"DIRECTION":"UN","MASTER_ID":15921,"ec":"2.4.1.184","compounds":"2 a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol = a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a 1,2-diacyl-sn-glycerol"}
{"X":19067,"RHEA_ID":15922,"DIRECTION":"LR","MASTER_ID":15921,"metacyc":"RXN-1226","compounds":"2 a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol => a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a 1,2-diacyl-sn-glycerol"}
{"X":19068,"RHEA_ID":15923,"compounds":"a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a 1,2-diacyl-sn-glycerol => 2 a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol"}
{"X":19069,"RHEA_ID":15925,"DIRECTION":"UN","MASTER_ID":15925,"ec":"1.1.1.160","compounds":"dihydrobunolol + NADP(+) = bunolol + H(+) + NADPH"}
{"X":19070,"RHEA_ID":15926,"compounds":"dihydrobunolol + NADP(+) => bunolol + H(+) + NADPH"}
{"X":19071,"RHEA_ID":15927,"compounds":"bunolol + H(+) + NADPH => dihydrobunolol + NADP(+)"}
{"X":19072,"RHEA_ID":25850,"compounds":"(S)-carvone + H(+) + NADH => (1S,5S)-carveol + NAD(+)"}
{"X":19073,"RHEA_ID":15929,"DIRECTION":"UN","MASTER_ID":15929,"ec":"3.5.3.21","metacyc":"3.5.3.21-RXN","compounds":"2 H(+) + 2 H2O + methylenediurea = CO2 + N-(hydroxymethyl)urea + 2 NH4(+)"}
{"X":19074,"RHEA_ID":15930,"compounds":"2 H(+) + 2 H2O + methylenediurea => CO2 + N-(hydroxymethyl)urea + 2 NH4(+)"}
{"X":19075,"RHEA_ID":15931,"compounds":"CO2 + N-(hydroxymethyl)urea + 2 NH4(+) => 2 H(+) + 2 H2O + methylenediurea"}
{"X":19076,"RHEA_ID":15933,"DIRECTION":"UN","MASTER_ID":15933,"ec":"1.1.1.77","compounds":"(S)-propane-1,2-diol + NAD(+) = (S)-lactaldehyde + H(+) + NADH"}
{"X":19077,"RHEA_ID":15934,"compounds":"(S)-propane-1,2-diol + NAD(+) => (S)-lactaldehyde + H(+) + NADH"}
{"X":19078,"RHEA_ID":15935,"compounds":"(S)-lactaldehyde + H(+) + NADH => (S)-propane-1,2-diol + NAD(+)"}
{"X":19079,"RHEA_ID":15937,"DIRECTION":"UN","MASTER_ID":15937,"ec":"1.1.1.2","compounds":"a primary alcohol + NADP(+) = an aldehyde + H(+) + NADPH"}
{"X":19080,"RHEA_ID":15937,"DIRECTION":"UN","MASTER_ID":15937,"ec":"1.1.1.71","compounds":"a primary alcohol + NADP(+) = an aldehyde + H(+) + NADPH"}
{"X":19081,"RHEA_ID":15938,"compounds":"a primary alcohol + NADP(+) => an aldehyde + H(+) + NADPH"}
{"X":19082,"RHEA_ID":15939,"DIRECTION":"RL","MASTER_ID":15937,"ecocyc":"ALCOHOL-DEHYDROGENASE-NADPORNOP%2b-RXN","metacyc":"ALCOHOL-DEHYDROGENASE-NADPORNOP%2b-RXN","compounds":"an aldehyde + H(+) + NADPH => a primary alcohol + NADP(+)"}
{"X":19083,"RHEA_ID":15939,"DIRECTION":"RL","MASTER_ID":15937,"ecocyc":"ALCOHOL-DEHYDROGENASE-NADPORNOP%2b-RXN","metacyc":"ALCOHOL-DEHYDROGENASE-NADP%2b-RXN","compounds":"an aldehyde + H(+) + NADPH => a primary alcohol + NADP(+)"}
{"X":19084,"RHEA_ID":15941,"DIRECTION":"UN","MASTER_ID":15941,"ec":"3.5.1.16","compounds":"H2O + N(2)-acetyl-L-ornithine = acetate + L-ornithine"}
{"X":19085,"RHEA_ID":15942,"DIRECTION":"LR","MASTER_ID":15941,"ecocyc":"ACETYLORNDEACET-RXN","compounds":"H2O + N(2)-acetyl-L-ornithine => acetate + L-ornithine"}
{"X":19086,"RHEA_ID":15943,"compounds":"acetate + L-ornithine => H2O + N(2)-acetyl-L-ornithine"}
{"X":19087,"RHEA_ID":25868,"DIRECTION":"UN","MASTER_ID":25868,"ec":"1.5.3.13","compounds":"H2O + N(1),N(12)-diacetylspermine + O2 = 3-acetamidopropanal + H2O2 + N(1)-acetylspermidine"}
{"X":19088,"RHEA_ID":15945,"compounds":"aldehydo-D-glucose 6-phosphate + L-lysyl-[protein] = H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein]"}
{"X":19089,"RHEA_ID":15946,"compounds":"aldehydo-D-glucose 6-phosphate + L-lysyl-[protein] => H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein]"}
{"X":19090,"RHEA_ID":15947,"compounds":"H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein] => aldehydo-D-glucose 6-phosphate + L-lysyl-[protein]"}
{"X":19091,"RHEA_ID":15948,"compounds":"aldehydo-D-glucose 6-phosphate + L-lysyl-[protein] <=> H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein]"}
{"X":19092,"RHEA_ID":15949,"DIRECTION":"UN","MASTER_ID":15949,"ec":"1.1.1.98","metacyc":"1.1.1.98-RXN","compounds":"(R)-2-hydroxyoctadecanoate + NAD(+) = 2-oxodecanoate + H(+) + NADH"}
{"X":19093,"RHEA_ID":15950,"compounds":"(R)-2-hydroxyoctadecanoate + NAD(+) => 2-oxodecanoate + H(+) + NADH"}
{"X":19094,"RHEA_ID":15951,"compounds":"2-oxodecanoate + H(+) + NADH => (R)-2-hydroxyoctadecanoate + NAD(+)"}
{"X":19095,"RHEA_ID":25876,"DIRECTION":"UN","MASTER_ID":25876,"ec":"1.4.3.16","compounds":"L-aspartate + O2 = H2O2 + iminosuccinate"}
{"X":19096,"RHEA_ID":15953,"DIRECTION":"UN","MASTER_ID":15953,"ec":"2.7.3.10","metacyc":"AGMATINE-KINASE-RXN","compounds":"agmatine + ATP = ADP + 2 H(+) + N(4)-phosphoagmatine"}
{"X":19097,"RHEA_ID":15954,"compounds":"agmatine + ATP => ADP + 2 H(+) + N(4)-phosphoagmatine"}
{"X":19098,"RHEA_ID":15955,"compounds":"ADP + 2 H(+) + N(4)-phosphoagmatine => agmatine + ATP"}
{"X":19099,"RHEA_ID":25880,"DIRECTION":"UN","MASTER_ID":25880,"ec":"1.13.12.15","compounds":"2 L-dopa + O2 = 2 3-(3,4-dihydroxyphenyl)pyruvate + 2 NH4(+)"}
{"X":19100,"RHEA_ID":15957,"DIRECTION":"UN","MASTER_ID":15957,"ec":"4.2.1.7","compounds":"D-altronate = 2-dehydro-3-deoxy-D-gluconate + H2O"}
{"X":19101,"RHEA_ID":15958,"DIRECTION":"LR","MASTER_ID":15957,"ecocyc":"ALTRODEHYDRAT-RXN","metacyc":"ALTRODEHYDRAT-RXN","compounds":"D-altronate => 2-dehydro-3-deoxy-D-gluconate + H2O"}
{"X":19102,"RHEA_ID":15959,"compounds":"2-dehydro-3-deoxy-D-gluconate + H2O => D-altronate"}
{"X":19103,"RHEA_ID":25884,"DIRECTION":"UN","MASTER_ID":25884,"ec":"2.1.3.11","metacyc":"RXN-9778","compounds":"carbamoyl phosphate + N(2)-succinyl-L-ornithine = H(+) + N(2)-succinyl-L-citrulline + phosphate"}
{"X":19104,"RHEA_ID":15961,"DIRECTION":"UN","MASTER_ID":15961,"ec":"2.4.1.178","compounds":"4-hydroxymandelonitrile + UDP-alpha-D-glucose = H(+) + taxiphyllin + UDP"}
{"X":19105,"RHEA_ID":15962,"DIRECTION":"LR","MASTER_ID":15961,"metacyc":"2.4.1.178-RXN","compounds":"4-hydroxymandelonitrile + UDP-alpha-D-glucose => H(+) + taxiphyllin + UDP"}
{"X":19106,"RHEA_ID":15963,"compounds":"H(+) + taxiphyllin + UDP => 4-hydroxymandelonitrile + UDP-alpha-D-glucose"}
{"X":19107,"RHEA_ID":25888,"DIRECTION":"UN","MASTER_ID":25888,"ec":"2.5.1.72","compounds":"dihydroxyacetone phosphate + iminosuccinate = H(+) + 2 H2O + phosphate + quinolinate"}
{"X":19108,"RHEA_ID":15965,"DIRECTION":"UN","MASTER_ID":15965,"ec":"3.1.4.39","compounds":"1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O = 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)"}
{"X":19109,"RHEA_ID":15966,"DIRECTION":"LR","MASTER_ID":15965,"metacyc":"3.1.4.39-RXN","compounds":"1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O => 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)"}
{"X":19110,"RHEA_ID":15967,"compounds":"1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+) => 1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O"}
{"X":19111,"RHEA_ID":15969,"DIRECTION":"UN","MASTER_ID":15969,"ec":"1.20.4.2","compounds":"2 glutathione + H(+) + methylarsonate = glutathione disulfide + H2O + methylarsonous acid"}
{"X":19112,"RHEA_ID":15970,"DIRECTION":"LR","MASTER_ID":15969,"metacyc":"1.20.4.2-RXN","reactome":"R-HSA-5696230.1","compounds":"2 glutathione + H(+) + methylarsonate => glutathione disulfide + H2O + methylarsonous acid"}
{"X":19113,"RHEA_ID":15971,"compounds":"glutathione disulfide + H2O + methylarsonous acid => 2 glutathione + H(+) + methylarsonate"}
{"X":19114,"RHEA_ID":25900,"DIRECTION":"UN","MASTER_ID":25900,"ec":"5.3.1.27","compounds":"D-arabino-hex-3-ulose 6-phosphate = beta-D-fructose 6-phosphate"}
{"X":19115,"RHEA_ID":15973,"DIRECTION":"UN","MASTER_ID":15973,"ec":"2.8.2.4","compounds":"3'-phosphoadenylyl sulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate + H(+)"}
{"X":19116,"RHEA_ID":15974,"DIRECTION":"LR","MASTER_ID":15973,"macie":"M0154","reactome":"R-HSA-176664.2","compounds":"3'-phosphoadenylyl sulfate + estrone => adenosine 3',5'-bisphosphate + estrone 3-sulfate + H(+)"}
{"X":19117,"RHEA_ID":15975,"compounds":"adenosine 3',5'-bisphosphate + estrone 3-sulfate + H(+) => 3'-phosphoadenylyl sulfate + estrone"}
{"X":19118,"RHEA_ID":25904,"DIRECTION":"UN","MASTER_ID":25904,"ec":"3.2.2.26","compounds":"futalosine + H2O = dehypoxanthine futalosine + hypoxanthine"}
{"X":19119,"RHEA_ID":15977,"DIRECTION":"UN","MASTER_ID":15977,"ec":"4.1.2.11","compounds":"(S)-4-hydroxymandelonitrile = 4-hydroxybenzaldehyde + hydrogen cyanide"}
{"X":19120,"RHEA_ID":15978,"DIRECTION":"LR","MASTER_ID":15977,"metacyc":"HYDROXYMANDELONITRILE-LYASE-RXN","compounds":"(S)-4-hydroxymandelonitrile => 4-hydroxybenzaldehyde + hydrogen cyanide"}
{"X":19121,"RHEA_ID":15979,"compounds":"4-hydroxybenzaldehyde + hydrogen cyanide => (S)-4-hydroxymandelonitrile"}
{"X":19122,"RHEA_ID":25908,"DIRECTION":"UN","MASTER_ID":25908,"ec":"1.1.3.41","compounds":"an alditol + O2 = an aldose + H2O2"}
{"X":19123,"RHEA_ID":15981,"DIRECTION":"UN","MASTER_ID":15981,"ec":"4.1.1.50","compounds":"H(+) + S-adenosyl-L-methionine = CO2 + S-adenosyl 3-(methylsulfanyl)propylamine"}
{"X":19124,"RHEA_ID":15982,"DIRECTION":"LR","MASTER_ID":15981,"ecocyc":"SAMDECARB-RXN","macie":"M0225","metacyc":"SAMDECARB-RXN","reactome":"R-HSA-351222.1","compounds":"H(+) + S-adenosyl-L-methionine => CO2 + S-adenosyl 3-(methylsulfanyl)propylamine"}
{"X":19125,"RHEA_ID":15983,"compounds":"CO2 + S-adenosyl 3-(methylsulfanyl)propylamine => H(+) + S-adenosyl-L-methionine"}
{"X":19126,"RHEA_ID":25912,"DIRECTION":"UN","MASTER_ID":25912,"ec":"1.3.99.17","compounds":"A + H2O + quinolin-5-ol = 5-hydroxyquinolin-2(1H)-one + AH2"}
{"X":19127,"RHEA_ID":15985,"DIRECTION":"UN","MASTER_ID":15985,"ec":"1.17.1.9","compounds":"formate + NAD(+) = CO2 + NADH"}
{"X":19128,"RHEA_ID":15986,"compounds":"formate + NAD(+) => CO2 + NADH"}
{"X":19129,"RHEA_ID":15987,"compounds":"CO2 + NADH => formate + NAD(+)"}
{"X":19130,"RHEA_ID":15989,"DIRECTION":"UN","MASTER_ID":15989,"ec":"1.1.1.34","compounds":"(R)-mevalonate + CoA + 2 NADP(+) = (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH"}
{"X":19131,"RHEA_ID":15990,"compounds":"(R)-mevalonate + CoA + 2 NADP(+) => (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH"}
{"X":19132,"RHEA_ID":15991,"DIRECTION":"RL","MASTER_ID":15989,"macie":"M0093","reactome":"R-HSA-191352.1","compounds":"(3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH => (R)-mevalonate + CoA + 2 NADP(+)"}
{"X":19133,"RHEA_ID":25920,"DIRECTION":"UN","MASTER_ID":25920,"ec":"1.3.99.17","compounds":"A + H2O + quinolin-7-ol = 7-hydroxyquinolin-2(1H)-one + AH2"}
{"X":19134,"RHEA_ID":15993,"DIRECTION":"UN","MASTER_ID":15993,"ec":"1.14.13.40","compounds":"anthraniloyl-CoA + 2 H(+) + 2 NADPH + O2 = 2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NADP(+)"}
{"X":19135,"RHEA_ID":15994,"DIRECTION":"LR","MASTER_ID":15993,"metacyc":"ANTHRANILOYL-COA-MONOOXYGENASE-RXN","compounds":"anthraniloyl-CoA + 2 H(+) + 2 NADPH + O2 => 2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NADP(+)"}
{"X":19136,"RHEA_ID":15995,"compounds":"2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NADP(+) => anthraniloyl-CoA + 2 H(+) + 2 NADPH + O2"}
{"X":19137,"RHEA_ID":25924,"DIRECTION":"UN","MASTER_ID":25924,"ec":"1.3.99.17","compounds":"A + H2O + quinolin-8-ol = 8-hydroxyquinolin-2(1H)-one + AH2"}
{"X":19138,"RHEA_ID":15997,"DIRECTION":"UN","MASTER_ID":15997,"ec":"1.14.13.40","compounds":"anthraniloyl-CoA + 2 H(+) + 2 NADH + O2 = 2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NAD(+)"}
{"X":19139,"RHEA_ID":15998,"DIRECTION":"LR","MASTER_ID":15997,"metacyc":"ANTHRANILOYL-COA-MONOOXYGENASE-RXN","compounds":"anthraniloyl-CoA + 2 H(+) + 2 NADH + O2 => 2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NAD(+)"}
{"X":19140,"RHEA_ID":15999,"compounds":"2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NAD(+) => anthraniloyl-CoA + 2 H(+) + 2 NADH + O2"}
{"X":19141,"RHEA_ID":25928,"DIRECTION":"UN","MASTER_ID":25928,"ec":"1.3.99.17","compounds":"3-methylquinoline + A + H2O = 3-methylquinolin-2(1H)-one + AH2"}
{"X":19142,"RHEA_ID":16001,"compounds":"H(+) + H2O + N(6)-methyl-AMP = IMP + methylamine"}
{"X":19143,"RHEA_ID":16002,"DIRECTION":"LR","MASTER_ID":16001,"reactome":"R-HSA-2161187.2","compounds":"H(+) + H2O + N(6)-methyl-AMP => IMP + methylamine"}
{"X":19144,"RHEA_ID":16003,"compounds":"IMP + methylamine => H(+) + H2O + N(6)-methyl-AMP"}
{"X":19145,"RHEA_ID":16004,"compounds":"H(+) + H2O + N(6)-methyl-AMP <=> IMP + methylamine"}
{"X":19146,"RHEA_ID":16005,"DIRECTION":"UN","MASTER_ID":16005,"ec":"4.2.1.42","compounds":"galactarate = 5-dehydro-4-deoxy-D-glucarate + H2O"}
{"X":19147,"RHEA_ID":16006,"DIRECTION":"LR","MASTER_ID":16005,"ecocyc":"GALACTARDEHYDRA-RXN","metacyc":"GALACTARDEHYDRA-RXN","compounds":"galactarate => 5-dehydro-4-deoxy-D-glucarate + H2O"}
{"X":19148,"RHEA_ID":16007,"compounds":"5-dehydro-4-deoxy-D-glucarate + H2O => galactarate"}
{"X":19149,"RHEA_ID":25936,"DIRECTION":"UN","MASTER_ID":25936,"ec":"1.3.99.17","compounds":"8-methylquinoline + A + H2O = 8-methylquinolin-2(1H)-one + AH2"}
{"X":19150,"RHEA_ID":16009,"DIRECTION":"UN","MASTER_ID":16009,"ec":"2.7.2.6","metacyc":"FORMATE-KINASE-RXN","compounds":"ATP + formate = ADP + formyl phosphate"}
{"X":19151,"RHEA_ID":16010,"compounds":"ATP + formate => ADP + formyl phosphate"}
{"X":19152,"RHEA_ID":16011,"compounds":"ADP + formyl phosphate => ATP + formate"}
{"X":19153,"RHEA_ID":25940,"DIRECTION":"UN","MASTER_ID":25940,"ec":"1.3.99.17","compounds":"8-chloroquinoline + A + H2O = 8-chloroquinolin-2(1H)-one + AH2"}
{"X":19154,"RHEA_ID":16013,"DIRECTION":"UN","MASTER_ID":16013,"ec":"6.1.1.14","compounds":"ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)"}
{"X":19155,"RHEA_ID":16014,"DIRECTION":"LR","MASTER_ID":16013,"ecocyc":"GLYCINE--TRNA-LIGASE-RXN","metacyc":"GLYCINE--TRNA-LIGASE-RXN","compounds":"ATP + glycine + tRNA(Gly) => AMP + diphosphate + glycyl-tRNA(Gly)"}
{"X":19156,"RHEA_ID":16015,"compounds":"AMP + diphosphate + glycyl-tRNA(Gly) => ATP + glycine + tRNA(Gly)"}
{"X":19157,"RHEA_ID":25948,"DIRECTION":"UN","MASTER_ID":25948,"ec":"2.7.1.174","compounds":"a 1,2-diacyl-sn-glycerol + CTP = a 1,2-diacyl-sn-glycero-3-phosphate + CDP + H(+)"}
{"X":19158,"RHEA_ID":16017,"DIRECTION":"UN","MASTER_ID":16017,"ec":"2.6.1.8","compounds":"2-oxoglutarate + L-ornithine = 5-amino-2-oxopentanoate + L-glutamate"}
{"X":19159,"RHEA_ID":16018,"compounds":"2-oxoglutarate + L-ornithine => 5-amino-2-oxopentanoate + L-glutamate"}
{"X":19160,"RHEA_ID":16019,"compounds":"5-amino-2-oxopentanoate + L-glutamate => 2-oxoglutarate + L-ornithine"}
{"X":19161,"RHEA_ID":25952,"DIRECTION":"UN","MASTER_ID":25952,"ec":"2.2.1.10","compounds":"1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + L-aspartate 4-semialdehyde = 2,3-dioxopropyl phosphate + 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate"}
{"X":19162,"RHEA_ID":16021,"DIRECTION":"UN","MASTER_ID":16021,"ec":"5.3.2.2","compounds":"oxaloacetate = enol-oxaloacetate"}
{"X":19163,"RHEA_ID":16022,"compounds":"oxaloacetate => enol-oxaloacetate"}
{"X":19164,"RHEA_ID":16023,"compounds":"enol-oxaloacetate => oxaloacetate"}
{"X":19165,"RHEA_ID":25956,"DIRECTION":"UN","MASTER_ID":25956,"ec":"1.4.1.24","compounds":"2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) = 3-dehydroquinate + H(+) + NADH + NH4(+)"}
{"X":19166,"RHEA_ID":16025,"DIRECTION":"UN","MASTER_ID":16025,"ec":"2.3.1.171","compounds":"an anthocyanidin 3-O-beta-D-glucoside + malonyl-CoA = an anthocyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + CoA"}
{"X":19167,"RHEA_ID":16026,"compounds":"an anthocyanidin 3-O-beta-D-glucoside + malonyl-CoA => an anthocyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + CoA"}
{"X":19168,"RHEA_ID":16027,"compounds":"an anthocyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + CoA => an anthocyanidin 3-O-beta-D-glucoside + malonyl-CoA"}
{"X":19169,"RHEA_ID":25960,"compounds":"benzoin + NADP(+) = benzil + H(+) + NADPH"}
{"X":19170,"RHEA_ID":16029,"DIRECTION":"UN","MASTER_ID":16029,"ec":"3.5.3.17","compounds":"3-guanidinopropanoate + H2O = beta-alanine + urea"}
{"X":19171,"RHEA_ID":16030,"compounds":"3-guanidinopropanoate + H2O => beta-alanine + urea"}
{"X":19172,"RHEA_ID":16031,"compounds":"beta-alanine + urea => 3-guanidinopropanoate + H2O"}
{"X":19173,"RHEA_ID":16033,"DIRECTION":"UN","MASTER_ID":16033,"ec":"1.14.11.12","compounds":"2-oxoglutarate + gibberellin A44 + O2 = CO2 + gibberellin A19 + H2O + succinate"}
{"X":19174,"RHEA_ID":16034,"DIRECTION":"LR","MASTER_ID":16033,"metacyc":"RXN1F-168","compounds":"2-oxoglutarate + gibberellin A44 + O2 => CO2 + gibberellin A19 + H2O + succinate"}
{"X":19175,"RHEA_ID":16035,"compounds":"CO2 + gibberellin A19 + H2O + succinate => 2-oxoglutarate + gibberellin A44 + O2"}
{"X":19176,"RHEA_ID":25968,"DIRECTION":"UN","MASTER_ID":25968,"ec":"1.1.1.320","compounds":"(S)-benzoin + NADP(+) = benzil + H(+) + NADPH"}
{"X":19177,"RHEA_ID":16037,"DIRECTION":"UN","MASTER_ID":16037,"ec":"2.4.2.2","compounds":"phosphate + thymidine = 2-deoxy-alpha-D-ribose 1-phosphate + thymine"}
{"X":19178,"RHEA_ID":16037,"DIRECTION":"UN","MASTER_ID":16037,"ec":"2.4.2.4","compounds":"phosphate + thymidine = 2-deoxy-alpha-D-ribose 1-phosphate + thymine"}
{"X":19179,"RHEA_ID":16038,"compounds":"phosphate + thymidine => 2-deoxy-alpha-D-ribose 1-phosphate + thymine"}
{"X":19180,"RHEA_ID":16039,"compounds":"2-deoxy-alpha-D-ribose 1-phosphate + thymine => phosphate + thymidine"}
{"X":19181,"RHEA_ID":25972,"DIRECTION":"UN","MASTER_ID":25972,"ec":"1.5.3.15","compounds":"H2O + N(8)-acetylspermidine + O2 = 4-acetamidobutanal + H2O2 + propane-1,3-diamine"}
{"X":19182,"RHEA_ID":16041,"DIRECTION":"UN","MASTER_ID":16041,"ec":"2.4.1.30","compounds":"[(1->3)-beta-D-glucosyl](n) + phosphate = [(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate"}
{"X":19183,"RHEA_ID":16041,"DIRECTION":"UN","MASTER_ID":16041,"ec":"2.4.1.97","compounds":"[(1->3)-beta-D-glucosyl](n) + phosphate = [(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate"}
{"X":19184,"RHEA_ID":16042,"compounds":"[(1->3)-beta-D-glucosyl](n) + phosphate => [(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate"}
{"X":19185,"RHEA_ID":16043,"compounds":"[(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate => [(1->3)-beta-D-glucosyl](n) + phosphate"}
{"X":19186,"RHEA_ID":16045,"DIRECTION":"UN","MASTER_ID":16045,"ec":"2.4.1.86","compounds":"a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP"}
{"X":19187,"RHEA_ID":16046,"DIRECTION":"LR","MASTER_ID":16045,"metacyc":"2.4.1.86-RXN","compounds":"a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose => a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP"}
{"X":19188,"RHEA_ID":16047,"compounds":"a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP => a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose"}
{"X":19189,"RHEA_ID":25981,"DIRECTION":"LR","MASTER_ID":25980,"metacyc":"RXN-9352","compounds":"(5S)-albaflavenol + H(+) + NADPH + O2 => albaflavenone + 2 H2O + NADP(+)"}
{"X":19190,"RHEA_ID":16049,"DIRECTION":"UN","MASTER_ID":16049,"ec":"2.7.8.26","compounds":"adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)"}
{"X":19191,"RHEA_ID":16050,"DIRECTION":"LR","MASTER_ID":16049,"ecocyc":"COBALAMINSYN-RXN","compounds":"adenosylcob(III)inamide-GDP + alpha-ribazole => adenosylcob(III)alamin + GMP + H(+)"}
{"X":19192,"RHEA_ID":16051,"compounds":"adenosylcob(III)alamin + GMP + H(+) => adenosylcob(III)inamide-GDP + alpha-ribazole"}
{"X":19193,"RHEA_ID":25985,"DIRECTION":"LR","MASTER_ID":25984,"metacyc":"RXN-9351","compounds":"(+)-epi-isozizaene + H(+) + NADPH + O2 => (5R)-albaflavenol + H2O + NADP(+)"}
{"X":19194,"RHEA_ID":16053,"DIRECTION":"UN","MASTER_ID":16053,"ec":"2.4.1.187","compounds":"N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UDP-N-acetyl-alpha-D-mannosamine = H(+) + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + UDP"}
{"X":19195,"RHEA_ID":16054,"DIRECTION":"LR","MASTER_ID":16053,"metacyc":"TEICHOICSYN2-RXN","compounds":"N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UDP-N-acetyl-alpha-D-mannosamine => H(+) + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + UDP"}
{"X":19196,"RHEA_ID":16055,"compounds":"H(+) + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + UDP => N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UDP-N-acetyl-alpha-D-mannosamine"}
{"X":19197,"RHEA_ID":25989,"DIRECTION":"LR","MASTER_ID":25988,"metacyc":"RXN-9353","compounds":"(5R)-albaflavenol + H(+) + NADPH + O2 => albaflavenone + 2 H2O + NADP(+)"}
{"X":19198,"RHEA_ID":16057,"DIRECTION":"UN","MASTER_ID":16057,"ec":"2.4.1.145","compounds":"N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP"}
{"X":19199,"RHEA_ID":16058,"DIRECTION":"LR","MASTER_ID":16057,"metacyc":"2.4.1.145-RXN","compounds":"N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP"}
{"X":19200,"RHEA_ID":16059,"compounds":"H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":19201,"RHEA_ID":16061,"DIRECTION":"UN","MASTER_ID":16061,"ec":"3.1.4.2","compounds":"H2O + sn-glycerol 3-phosphocholine = choline + H(+) + sn-glycerol 3-phosphate"}
{"X":19202,"RHEA_ID":16062,"DIRECTION":"LR","MASTER_ID":16061,"metacyc":"3.1.4.2-RXN","reactome":"R-HSA-6814132.1","compounds":"H2O + sn-glycerol 3-phosphocholine => choline + H(+) + sn-glycerol 3-phosphate"}
{"X":19203,"RHEA_ID":16062,"DIRECTION":"LR","MASTER_ID":16061,"metacyc":"3.1.4.2-RXN","reactome":"R-HSA-1483116.2","compounds":"H2O + sn-glycerol 3-phosphocholine => choline + H(+) + sn-glycerol 3-phosphate"}
{"X":19204,"RHEA_ID":16063,"compounds":"choline + H(+) + sn-glycerol 3-phosphate => H2O + sn-glycerol 3-phosphocholine"}
{"X":19205,"RHEA_ID":25998,"compounds":"H2O2 + N-(3-acetamidopropyl)-4-aminobutanal + propane-1,3-diamine => H2O + N(1)-acetylspermine + O2"}
{"X":19206,"RHEA_ID":16065,"DIRECTION":"UN","MASTER_ID":16065,"ec":"1.14.11.18","compounds":"2-oxoglutarate + O2 + phytanoyl-CoA = 2-hydroxyphytanoyl-CoA + CO2 + succinate"}
{"X":19207,"RHEA_ID":16066,"DIRECTION":"LR","MASTER_ID":16065,"metacyc":"1.14.11.18-RXN","reactome":"R-HSA-389639.2","compounds":"2-oxoglutarate + O2 + phytanoyl-CoA => 2-hydroxyphytanoyl-CoA + CO2 + succinate"}
{"X":19208,"RHEA_ID":16067,"compounds":"2-hydroxyphytanoyl-CoA + CO2 + succinate => 2-oxoglutarate + O2 + phytanoyl-CoA"}
{"X":19209,"RHEA_ID":26004,"compounds":"D-xylulose 5-phosphate + H(+) + NADH => D-arabinitol 1-phosphate + NAD(+)"}
{"X":19210,"RHEA_ID":16069,"DIRECTION":"UN","MASTER_ID":16069,"ec":"3.5.4.5","compounds":"cytidine + H(+) + H2O = NH4(+) + uridine"}
{"X":19211,"RHEA_ID":16070,"DIRECTION":"LR","MASTER_ID":16069,"ecocyc":"CYTIDEAM2-RXN","macie":"M0097","metacyc":"CYTIDEAM2-RXN","compounds":"cytidine + H(+) + H2O => NH4(+) + uridine"}
{"X":19212,"RHEA_ID":16071,"compounds":"NH4(+) + uridine => cytidine + H(+) + H2O"}
{"X":19213,"RHEA_ID":26008,"compounds":"beta-D-galacturonosyl di-trans,nona-cis-dodecaprenyl phosphate + UDP => di-trans,nona-cis-dodecaprenyl phosphate + UDP-alpha-D-galacturonate"}
{"X":19214,"RHEA_ID":16073,"DIRECTION":"UN","MASTER_ID":16073,"ec":"4.1.1.64","compounds":"2,2-dialkylglycine + H(+) + pyruvate = CO2 + dialkyl ketone + L-alanine"}
{"X":19215,"RHEA_ID":16074,"compounds":"2,2-dialkylglycine + H(+) + pyruvate => CO2 + dialkyl ketone + L-alanine"}
{"X":19216,"RHEA_ID":16075,"compounds":"CO2 + dialkyl ketone + L-alanine => 2,2-dialkylglycine + H(+) + pyruvate"}
{"X":19217,"RHEA_ID":16081,"DIRECTION":"UN","MASTER_ID":16081,"ec":"3.1.3.14","compounds":"(2R)-S-methyl-3-phospho-1-thioglycerate + H2O = (2R)-S-methyl-1-thioglycerate + phosphate"}
{"X":19218,"RHEA_ID":16082,"DIRECTION":"LR","MASTER_ID":16081,"metacyc":"3.1.3.14-RXN","compounds":"(2R)-S-methyl-3-phospho-1-thioglycerate + H2O => (2R)-S-methyl-1-thioglycerate + phosphate"}
{"X":19219,"RHEA_ID":16083,"compounds":"(2R)-S-methyl-1-thioglycerate + phosphate => (2R)-S-methyl-3-phospho-1-thioglycerate + H2O"}
{"X":19220,"RHEA_ID":26016,"compounds":"3-dehydroquinate => 3,7-dideoxy-D-threo-hepto-2,6-diuolosonate"}
{"X":19221,"RHEA_ID":16085,"DIRECTION":"UN","MASTER_ID":16085,"ec":"6.3.2.10","compounds":"ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine"}
{"X":19222,"RHEA_ID":16086,"DIRECTION":"LR","MASTER_ID":16085,"metacyc":"6.3.2.10-RXN","compounds":"ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine"}
{"X":19223,"RHEA_ID":16087,"compounds":"ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine => ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine"}
{"X":19224,"RHEA_ID":26021,"compounds":"beta-D-fructofuranosyl alpha-D-mannopyranoside + phosphate => beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + H2O"}
{"X":19225,"RHEA_ID":16089,"DIRECTION":"UN","MASTER_ID":16089,"ec":"3.1.3.75","compounds":"H2O + phosphoethanolamine = ethanolamine + phosphate"}
{"X":19226,"RHEA_ID":16090,"DIRECTION":"LR","MASTER_ID":16089,"ecocyc":"RXN-7948","metacyc":"RXN-7948","reactome":"R-HSA-1483096.2","compounds":"H2O + phosphoethanolamine => ethanolamine + phosphate"}
{"X":19227,"RHEA_ID":16091,"compounds":"ethanolamine + phosphate => H2O + phosphoethanolamine"}
{"X":19228,"RHEA_ID":16093,"compounds":"(24R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24R)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":19229,"RHEA_ID":16094,"compounds":"(24R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24R)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":19230,"RHEA_ID":16095,"compounds":"(24R)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (24R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":19231,"RHEA_ID":16096,"compounds":"(24R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24R)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":19232,"RHEA_ID":16097,"DIRECTION":"UN","MASTER_ID":16097,"ec":"3.7.1.6","compounds":"acetylpyruvate + H2O = acetate + H(+) + pyruvate"}
{"X":19233,"RHEA_ID":16098,"DIRECTION":"LR","MASTER_ID":16097,"metacyc":"ACETYLPYRUVATE-HYDROLASE-RXN","compounds":"acetylpyruvate + H2O => acetate + H(+) + pyruvate"}
{"X":19234,"RHEA_ID":16099,"compounds":"acetate + H(+) + pyruvate => acetylpyruvate + H2O"}
{"X":19235,"RHEA_ID":16101,"DIRECTION":"UN","MASTER_ID":16101,"ec":"2.8.2.5","compounds":"n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate = n adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate + n H(+)"}
{"X":19236,"RHEA_ID":16102,"DIRECTION":"LR","MASTER_ID":16101,"metacyc":"CHONDROITIN-4-SULFOTRANSFERASE-RXN","compounds":"n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate => n adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate + n H(+)"}
{"X":19237,"RHEA_ID":16103,"compounds":"n adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate + n H(+) => n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate"}
{"X":19238,"RHEA_ID":26037,"compounds":"3,8'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":19239,"RHEA_ID":16105,"DIRECTION":"UN","MASTER_ID":16105,"ec":"4.2.1.17","compounds":"a (3S)-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O"}
{"X":19240,"RHEA_ID":16106,"compounds":"a (3S)-hydroxyacyl-CoA => a (2E)-enoyl-CoA + H2O"}
{"X":19241,"RHEA_ID":16107,"DIRECTION":"RL","MASTER_ID":16105,"ecocyc":"ENOYL-COA-HYDRAT-RXN","metacyc":"ENOYL-COA-HYDRAT-RXN","compounds":"a (2E)-enoyl-CoA + H2O => a (3S)-hydroxyacyl-CoA"}
{"X":19242,"RHEA_ID":16109,"DIRECTION":"UN","MASTER_ID":16109,"ec":"2.7.1.11","compounds":"ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)"}
{"X":19243,"RHEA_ID":16110,"DIRECTION":"LR","MASTER_ID":16109,"ecocyc":"6PFRUCTPHOS-RXN","metacyc":"6PFRUCTPHOS-RXN","compounds":"ATP + beta-D-fructose 6-phosphate => ADP + beta-D-fructose 1,6-bisphosphate + H(+)"}
{"X":19244,"RHEA_ID":16111,"compounds":"ADP + beta-D-fructose 1,6-bisphosphate + H(+) => ATP + beta-D-fructose 6-phosphate"}
{"X":19245,"RHEA_ID":26045,"compounds":"CoA + N-acetyl-9-O-acetylneuraminate => acetyl-CoA + N-acetylneuraminate"}
{"X":19246,"RHEA_ID":16113,"DIRECTION":"UN","MASTER_ID":16113,"ec":"1.16.1.6","compounds":"2 [cyanocobalamin reductase]-cob(II)alamin + 2 hydrogen cyanide + NADP(+) = 2 apo--[cyanocobalamin reductase] + 2 cyanocob(III)alamin + H(+) + NADPH"}
{"X":19247,"RHEA_ID":16114,"compounds":"2 [cyanocobalamin reductase]-cob(II)alamin + 2 hydrogen cyanide + NADP(+) => 2 apo--[cyanocobalamin reductase] + 2 cyanocob(III)alamin + H(+) + NADPH"}
{"X":19248,"RHEA_ID":16115,"DIRECTION":"RL","MASTER_ID":16113,"metacyc":"1.6.99.12-RXN","compounds":"2 apo--[cyanocobalamin reductase] + 2 cyanocob(III)alamin + H(+) + NADPH => 2 [cyanocobalamin reductase]-cob(II)alamin + 2 hydrogen cyanide + NADP(+)"}
{"X":19249,"RHEA_ID":16117,"DIRECTION":"UN","MASTER_ID":16117,"ec":"6.2.1.16","compounds":"acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate"}
{"X":19250,"RHEA_ID":16118,"DIRECTION":"LR","MASTER_ID":16117,"reactome":"R-HSA-5694494.1","compounds":"acetoacetate + ATP + CoA => acetoacetyl-CoA + AMP + diphosphate"}
{"X":19251,"RHEA_ID":16119,"compounds":"acetoacetyl-CoA + AMP + diphosphate => acetoacetate + ATP + CoA"}
{"X":19252,"RHEA_ID":26053,"compounds":"glyceollin III + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":19253,"RHEA_ID":16121,"DIRECTION":"UN","MASTER_ID":16121,"ec":"3.5.2.2","compounds":"5,6-dihydrouracil + H2O = 3-(carbamoylamino)propanoate + H(+)"}
{"X":19254,"RHEA_ID":16122,"DIRECTION":"LR","MASTER_ID":16121,"reactome":"R-HSA-73589.2","compounds":"5,6-dihydrouracil + H2O => 3-(carbamoylamino)propanoate + H(+)"}
{"X":19255,"RHEA_ID":16123,"compounds":"3-(carbamoylamino)propanoate + H(+) => 5,6-dihydrouracil + H2O"}
{"X":19256,"RHEA_ID":26057,"compounds":"diphosphate + GDP-valienol => GTP + H(+) + valienol 1-phosphate"}
{"X":19257,"RHEA_ID":16125,"DIRECTION":"UN","MASTER_ID":16125,"ec":"2.7.1.1","compounds":"ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+)"}
{"X":19258,"RHEA_ID":16125,"DIRECTION":"UN","MASTER_ID":16125,"ec":"2.7.1.4","compounds":"ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+)"}
{"X":19259,"RHEA_ID":16126,"DIRECTION":"LR","MASTER_ID":16125,"ecocyc":"FRUCTOKINASE-RXN","metacyc":"FRUCTOKINASE-RXN","compounds":"ATP + D-fructose => ADP + D-fructose 6-phosphate + H(+)"}
{"X":19260,"RHEA_ID":16127,"compounds":"ADP + D-fructose 6-phosphate + H(+) => ATP + D-fructose"}
{"X":19261,"RHEA_ID":16129,"DIRECTION":"UN","MASTER_ID":16129,"ec":"1.1.1.65","compounds":"NADP(+) + pyridoxine = H(+) + NADPH + pyridoxal"}
{"X":19262,"RHEA_ID":16130,"compounds":"NADP(+) + pyridoxine => H(+) + NADPH + pyridoxal"}
{"X":19263,"RHEA_ID":16131,"compounds":"H(+) + NADPH + pyridoxal => NADP(+) + pyridoxine"}
{"X":19264,"RHEA_ID":36621,"compounds":"CoA + H(+) + N-(2-hydroxydocosanoyl)-sphinganine => 2-hydroxydocosanoyl-CoA + sphinganine"}
{"X":19265,"RHEA_ID":16133,"compounds":"H2O + N(1)-acetylspermine + O2 = 3-aminopropanal + H2O2 + N(1)-acetylspermidine"}
{"X":19266,"RHEA_ID":16134,"compounds":"H2O + N(1)-acetylspermine + O2 => 3-aminopropanal + H2O2 + N(1)-acetylspermidine"}
{"X":19267,"RHEA_ID":16135,"compounds":"3-aminopropanal + H2O2 + N(1)-acetylspermidine => H2O + N(1)-acetylspermine + O2"}
{"X":19268,"RHEA_ID":26071,"compounds":"3-(hydrohydroxyphosphoryl)pyruvate + acetyl-CoA + H2O <=> CoA + H(+) + phosphinomethylmalate"}
{"X":19269,"RHEA_ID":16137,"DIRECTION":"UN","MASTER_ID":16137,"ec":"1.1.1.285","compounds":"2'-deoxymugineate + NADP(+) = 3''-deamino-3''-oxonicotianamine + H(+) + NADPH"}
{"X":19270,"RHEA_ID":16138,"compounds":"2'-deoxymugineate + NADP(+) => 3''-deamino-3''-oxonicotianamine + H(+) + NADPH"}
{"X":19271,"RHEA_ID":16139,"DIRECTION":"RL","MASTER_ID":16137,"metacyc":"1.1.1.285-RXN","compounds":"3''-deamino-3''-oxonicotianamine + H(+) + NADPH => 2'-deoxymugineate + NADP(+)"}
{"X":19272,"RHEA_ID":36629,"compounds":"CoA + H(+) + N-(2-hydroxytetracosanoyl)sphinganine => 2-hydroxytetracosanoyl-CoA + sphinganine"}
{"X":19273,"RHEA_ID":16141,"DIRECTION":"UN","MASTER_ID":16141,"ec":"1.1.1.285","compounds":"2'-deoxymugineate + NAD(+) = 3''-deamino-3''-oxonicotianamine + H(+) + NADH"}
{"X":19274,"RHEA_ID":16142,"compounds":"2'-deoxymugineate + NAD(+) => 3''-deamino-3''-oxonicotianamine + H(+) + NADH"}
{"X":19275,"RHEA_ID":16143,"DIRECTION":"RL","MASTER_ID":16141,"metacyc":"1.1.1.285-RXN","compounds":"3''-deamino-3''-oxonicotianamine + H(+) + NADH => 2'-deoxymugineate + NAD(+)"}
{"X":19276,"RHEA_ID":16145,"DIRECTION":"UN","MASTER_ID":16145,"ec":"1.14.18.2","compounds":"2 [Fe(II)-cytochrome b5] + CMP-N-acetyl-beta-neuraminate + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + CMP-N-glycoloyl-beta-neuraminate + H2O"}
{"X":19277,"RHEA_ID":16146,"DIRECTION":"LR","MASTER_ID":16145,"metacyc":"1.14.18.2-RXN","compounds":"2 [Fe(II)-cytochrome b5] + CMP-N-acetyl-beta-neuraminate + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + CMP-N-glycoloyl-beta-neuraminate + H2O"}
{"X":19278,"RHEA_ID":16147,"compounds":"2 [Fe(III)-cytochrome b5] + CMP-N-glycoloyl-beta-neuraminate + H2O => 2 [Fe(II)-cytochrome b5] + CMP-N-acetyl-beta-neuraminate + 2 H(+) + O2"}
{"X":19279,"RHEA_ID":36637,"compounds":"7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-adenosyl-L-homocysteine => 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine"}
{"X":19280,"RHEA_ID":16149,"DIRECTION":"UN","MASTER_ID":16149,"ec":"2.4.2.12","compounds":"beta-nicotinamide D-ribonucleotide + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide"}
{"X":19281,"RHEA_ID":16150,"compounds":"beta-nicotinamide D-ribonucleotide + diphosphate => 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide"}
{"X":19282,"RHEA_ID":16151,"DIRECTION":"RL","MASTER_ID":16149,"metacyc":"2.4.2.12-RXN","compounds":"5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide => beta-nicotinamide D-ribonucleotide + diphosphate"}
{"X":19283,"RHEA_ID":36641,"compounds":"3-O-methylphospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenol + S-adenosyl-L-homocysteine => 3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-di-trans,octa-cis-undecaprenol + S-adenosyl-L-methionine"}
{"X":19284,"RHEA_ID":16153,"DIRECTION":"UN","MASTER_ID":16153,"ec":"1.4.3.21","compounds":"an aliphatic amine + H2O + O2 = an aldehyde + H2O2 + NH4(+)"}
{"X":19285,"RHEA_ID":16154,"DIRECTION":"LR","MASTER_ID":16153,"ecocyc":"AMINEOXID-RXN","metacyc":"AMINEOXID-RXN","compounds":"an aliphatic amine + H2O + O2 => an aldehyde + H2O2 + NH4(+)"}
{"X":19286,"RHEA_ID":16155,"compounds":"an aldehyde + H2O2 + NH4(+) => an aliphatic amine + H2O + O2"}
{"X":19287,"RHEA_ID":16157,"DIRECTION":"UN","MASTER_ID":16157,"ec":"1.6.2.6","compounds":"2 [Fe(III)-leghemoglobin] + NADPH = 2 [Fe(II)-leghemoglobin] + H(+) + NADP(+)"}
{"X":19288,"RHEA_ID":16158,"compounds":"2 [Fe(III)-leghemoglobin] + NADPH => 2 [Fe(II)-leghemoglobin] + H(+) + NADP(+)"}
{"X":19289,"RHEA_ID":16159,"compounds":"2 [Fe(II)-leghemoglobin] + H(+) + NADP(+) => 2 [Fe(III)-leghemoglobin] + NADPH"}
{"X":19290,"RHEA_ID":16161,"DIRECTION":"UN","MASTER_ID":16161,"ec":"1.6.2.6","compounds":"2 [Fe(III)-leghemoglobin] + NADH = 2 [Fe(II)-leghemoglobin] + H(+) + NAD(+)"}
{"X":19291,"RHEA_ID":16162,"compounds":"2 [Fe(III)-leghemoglobin] + NADH => 2 [Fe(II)-leghemoglobin] + H(+) + NAD(+)"}
{"X":19292,"RHEA_ID":16163,"compounds":"2 [Fe(II)-leghemoglobin] + H(+) + NAD(+) => 2 [Fe(III)-leghemoglobin] + NADH"}
{"X":19293,"RHEA_ID":16165,"DIRECTION":"UN","MASTER_ID":16165,"ec":"1.13.12.3","compounds":"L-tryptophan + O2 = CO2 + H2O + indole-3-acetamide"}
{"X":19294,"RHEA_ID":16166,"DIRECTION":"LR","MASTER_ID":16165,"metacyc":"TRYPTOPHAN-2-MONOOXYGENASE-RXN","compounds":"L-tryptophan + O2 => CO2 + H2O + indole-3-acetamide"}
{"X":19295,"RHEA_ID":16167,"compounds":"CO2 + H2O + indole-3-acetamide => L-tryptophan + O2"}
{"X":19296,"RHEA_ID":36657,"compounds":"descarbamoylnovobiocin + H(+) + S-adenosyl-L-homocysteine => desmethyldescarbamoylnovobiocin + S-adenosyl-L-methionine"}
{"X":19297,"RHEA_ID":16169,"DIRECTION":"UN","MASTER_ID":16169,"ec":"6.3.1.2","compounds":"ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate"}
{"X":19298,"RHEA_ID":16170,"DIRECTION":"LR","MASTER_ID":16169,"ecocyc":"GLUTAMINESYN-RXN","reactome":"R-HSA-70606.3","compounds":"ATP + L-glutamate + NH4(+) => ADP + H(+) + L-glutamine + phosphate"}
{"X":19299,"RHEA_ID":16171,"compounds":"ADP + H(+) + L-glutamine + phosphate => ATP + L-glutamate + NH4(+)"}
{"X":19300,"RHEA_ID":26108,"compounds":"homocitrate <=> cis-homoaconitate + H2O"}
{"X":19301,"RHEA_ID":16173,"DIRECTION":"UN","MASTER_ID":16173,"ec":"4.2.1.78","compounds":"(4-hydroxyphenyl)acetaldehyde + dopamine = (S)-norcoclaurine + H2O"}
{"X":19302,"RHEA_ID":16174,"DIRECTION":"LR","MASTER_ID":16173,"metacyc":"S-NORLAUDANOSOLINE-SYNTHASE-RXN","compounds":"(4-hydroxyphenyl)acetaldehyde + dopamine => (S)-norcoclaurine + H2O"}
{"X":19303,"RHEA_ID":16175,"compounds":"(S)-norcoclaurine + H2O => (4-hydroxyphenyl)acetaldehyde + dopamine"}
{"X":19304,"RHEA_ID":36665,"compounds":"(2S,5S)-5-carboxymethylproline + CO2 + CoA => (S)-1-pyrroline-5-carboxylate + H(+) + H2O + malonyl-CoA"}
{"X":19305,"RHEA_ID":16177,"DIRECTION":"UN","MASTER_ID":16177,"ec":"1.2.1.36","compounds":"H2O + NAD(+) + retinal = 2 H(+) + NADH + retinoate"}
{"X":19306,"RHEA_ID":16178,"compounds":"H2O + NAD(+) + retinal => 2 H(+) + NADH + retinoate"}
{"X":19307,"RHEA_ID":16179,"compounds":"2 H(+) + NADH + retinoate => H2O + NAD(+) + retinal"}
{"X":19308,"RHEA_ID":16180,"compounds":"H2O + NAD(+) + retinal <=> 2 H(+) + NADH + retinoate"}
{"X":19309,"RHEA_ID":16181,"DIRECTION":"UN","MASTER_ID":16181,"ec":"2.1.1.82","compounds":"3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine = 3',4',5-trihydroxy-3,7-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine"}
{"X":19310,"RHEA_ID":16182,"DIRECTION":"LR","MASTER_ID":16181,"metacyc":"2.1.1.82-RXN","compounds":"3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine => 3',4',5-trihydroxy-3,7-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine"}
{"X":19311,"RHEA_ID":16183,"compounds":"3',4',5-trihydroxy-3,7-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine => 3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine"}
{"X":19312,"RHEA_ID":36673,"compounds":"CoA + H(+) + N-[(17Z)-hexacosenoyl]dihydrosphingosine => (17Z)-hexacosenoyl-CoA + sphinganine"}
{"X":19313,"RHEA_ID":16185,"DIRECTION":"UN","MASTER_ID":16185,"ec":"1.2.1.3","metacyc":"ALDEHYDE-DEHYDROGENASE-NADORNOP%252b-RXN","compounds":"an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH"}
{"X":19314,"RHEA_ID":16185,"DIRECTION":"UN","MASTER_ID":16185,"ec":"1.2.1.5","metacyc":"ALDEHYDE-DEHYDROGENASE-NADORNOP%252b-RXN","compounds":"an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH"}
{"X":19315,"RHEA_ID":16186,"DIRECTION":"LR","MASTER_ID":16185,"metacyc":"ALDHDEHYDROG-RXN","compounds":"an aldehyde + H2O + NAD(+) => a carboxylate + 2 H(+) + NADH"}
{"X":19316,"RHEA_ID":16187,"compounds":"a carboxylate + 2 H(+) + NADH => an aldehyde + H2O + NAD(+)"}
{"X":19317,"RHEA_ID":16189,"DIRECTION":"UN","MASTER_ID":16189,"ec":"1.13.11.27","compounds":"3-(4-hydroxyphenyl)pyruvate + O2 = CO2 + homogentisate"}
{"X":19318,"RHEA_ID":16190,"DIRECTION":"LR","MASTER_ID":16189,"metacyc":"4-HYDROXYPHENYLPYRUVATE-DIOXYGENASE-RXN","reactome":"R-HSA-71163.4","compounds":"3-(4-hydroxyphenyl)pyruvate + O2 => CO2 + homogentisate"}
{"X":19319,"RHEA_ID":16191,"compounds":"CO2 + homogentisate => 3-(4-hydroxyphenyl)pyruvate + O2"}
{"X":19320,"RHEA_ID":26132,"compounds":"2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+)"}
{"X":19321,"RHEA_ID":16193,"DIRECTION":"UN","MASTER_ID":16193,"ec":"3.8.1.11","compounds":"an (R)-2-haloacid + H2O = a (2R)-2-hydroxycarboxylate + a halide anion + H(+)"}
{"X":19322,"RHEA_ID":16194,"DIRECTION":"LR","MASTER_ID":16193,"metacyc":"RXN-6263","compounds":"an (R)-2-haloacid + H2O => a (2R)-2-hydroxycarboxylate + a halide anion + H(+)"}
{"X":19323,"RHEA_ID":16195,"compounds":"a (2R)-2-hydroxycarboxylate + a halide anion + H(+) => an (R)-2-haloacid + H2O"}
{"X":19324,"RHEA_ID":16197,"DIRECTION":"UN","MASTER_ID":16197,"ec":"1.1.1.157","compounds":"(3S)-hydroxybutanoyl-CoA + NADP(+) = acetoacetyl-CoA + H(+) + NADPH"}
{"X":19325,"RHEA_ID":16198,"compounds":"(3S)-hydroxybutanoyl-CoA + NADP(+) => acetoacetyl-CoA + H(+) + NADPH"}
{"X":19326,"RHEA_ID":16199,"DIRECTION":"RL","MASTER_ID":16197,"metacyc":"3-HYDROXYBUTYRYL-COA-DEHYDROGENASE-RXN","compounds":"acetoacetyl-CoA + H(+) + NADPH => (3S)-hydroxybutanoyl-CoA + NADP(+)"}
{"X":19327,"RHEA_ID":36690,"compounds":"hexadecanoyl-CoA + sphing-4-enine <=> CoA + H(+) + N-hexadecanoylsphing-4-enine"}
{"X":19328,"RHEA_ID":16201,"DIRECTION":"UN","MASTER_ID":16201,"ec":"4.1.3.38","compounds":"4-amino-4-deoxychorismate = 4-aminobenzoate + H(+) + pyruvate"}
{"X":19329,"RHEA_ID":16202,"DIRECTION":"LR","MASTER_ID":16201,"ecocyc":"ADCLY-RXN","macie":"M0305","compounds":"4-amino-4-deoxychorismate => 4-aminobenzoate + H(+) + pyruvate"}
{"X":19330,"RHEA_ID":16203,"compounds":"4-aminobenzoate + H(+) + pyruvate => 4-amino-4-deoxychorismate"}
{"X":19331,"RHEA_ID":26143,"compounds":"2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + H2O <=> 5-amino-6-(5-phospho-D-ribitylamino)uracil + NH4(+)"}
{"X":19332,"RHEA_ID":16205,"compounds":"H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein] = N(6)-(D-fructosyl)-L-lysyl-[protein] + phosphate"}
{"X":19333,"RHEA_ID":16206,"compounds":"H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein] => N(6)-(D-fructosyl)-L-lysyl-[protein] + phosphate"}
{"X":19334,"RHEA_ID":16207,"compounds":"N(6)-(D-fructosyl)-L-lysyl-[protein] + phosphate => H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein]"}
{"X":19335,"RHEA_ID":16208,"compounds":"H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein] <=> N(6)-(D-fructosyl)-L-lysyl-[protein] + phosphate"}
{"X":19336,"RHEA_ID":16209,"DIRECTION":"UN","MASTER_ID":16209,"ec":"5.4.99.60","compounds":"Co-precorrin-8X = cob(II)yrinate"}
{"X":19337,"RHEA_ID":16210,"DIRECTION":"LR","MASTER_ID":16209,"metacyc":"RXN-8768","compounds":"Co-precorrin-8X => cob(II)yrinate"}
{"X":19338,"RHEA_ID":16211,"compounds":"cob(II)yrinate => Co-precorrin-8X"}
{"X":19339,"RHEA_ID":26151,"compounds":"2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) <=> 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + NADH"}
{"X":19340,"RHEA_ID":16213,"DIRECTION":"UN","MASTER_ID":16213,"ec":"2.4.1.224","compounds":"3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP"}
{"X":19341,"RHEA_ID":16214,"DIRECTION":"LR","MASTER_ID":16213,"metacyc":"2.4.1.224-RXN","compounds":"3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP"}
{"X":19342,"RHEA_ID":16215,"compounds":"3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP => 3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":19343,"RHEA_ID":46618,"compounds":"(23S)-23,25-dihydroxycalciol + H2O + 2 oxidized [adrenodoxin] => calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}
{"X":19344,"RHEA_ID":16217,"DIRECTION":"UN","MASTER_ID":16217,"ec":"3.1.1.15","compounds":"H2O + L-arabinono-1,4-lactone = H(+) + L-arabinonate"}
{"X":19345,"RHEA_ID":16218,"DIRECTION":"LR","MASTER_ID":16217,"metacyc":"L-ARABINONOLACTONASE-RXN","compounds":"H2O + L-arabinono-1,4-lactone => H(+) + L-arabinonate"}
{"X":19346,"RHEA_ID":16219,"compounds":"H(+) + L-arabinonate => H2O + L-arabinono-1,4-lactone"}
{"X":19347,"RHEA_ID":26159,"compounds":"D-mannose + NADP(+) <=> D-glucosone + H(+) + NADPH"}
{"X":19348,"RHEA_ID":16221,"DIRECTION":"UN","MASTER_ID":16221,"ec":"2.4.1.223","compounds":"3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP"}
{"X":19349,"RHEA_ID":16222,"DIRECTION":"LR","MASTER_ID":16221,"metacyc":"2.4.1.223-RXN","compounds":"3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP"}
{"X":19350,"RHEA_ID":16223,"compounds":"3-O-(alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":19351,"RHEA_ID":26164,"compounds":"AH2 + echinenone + O2 = 4'-hydroxyechinenone + A + H2O"}
{"X":19352,"RHEA_ID":16225,"DIRECTION":"UN","MASTER_ID":16225,"ec":"3.5.2.12","compounds":"1,8-diazacyclotetradecane-2,9-dione + H2O = N-(6-aminohexanoyl)-6-aminohexanoate"}
{"X":19353,"RHEA_ID":16226,"DIRECTION":"LR","MASTER_ID":16225,"metacyc":"3.5.2.12-RXN","compounds":"1,8-diazacyclotetradecane-2,9-dione + H2O => N-(6-aminohexanoyl)-6-aminohexanoate"}
{"X":19354,"RHEA_ID":16227,"compounds":"N-(6-aminohexanoyl)-6-aminohexanoate => 1,8-diazacyclotetradecane-2,9-dione + H2O"}
{"X":19355,"RHEA_ID":26168,"DIRECTION":"UN","MASTER_ID":26168,"ec":"3.7.1.20","compounds":"3-fumarylpyruvate + H2O = fumarate + H(+) + pyruvate"}
{"X":19356,"RHEA_ID":16229,"DIRECTION":"UN","MASTER_ID":16229,"ec":"2.7.7.41","compounds":"a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate"}
{"X":19357,"RHEA_ID":16230,"DIRECTION":"LR","MASTER_ID":16229,"ecocyc":"CDPDIGLYSYN-RXN","metacyc":"CDPDIGLYSYN-RXN","compounds":"a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) => a CDP-1,2-diacyl-sn-glycerol + diphosphate"}
{"X":19358,"RHEA_ID":16231,"compounds":"a CDP-1,2-diacyl-sn-glycerol + diphosphate => a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+)"}
{"X":19359,"RHEA_ID":16233,"DIRECTION":"UN","MASTER_ID":16233,"ec":"1.1.1.169","compounds":"(R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH"}
{"X":19360,"RHEA_ID":16234,"compounds":"(R)-pantoate + NADP(+) => 2-dehydropantoate + H(+) + NADPH"}
{"X":19361,"RHEA_ID":16235,"DIRECTION":"RL","MASTER_ID":16233,"ecocyc":"2-DEHYDROPANTOATE-REDUCT-RXN","metacyc":"2-DEHYDROPANTOATE-REDUCT-RXN","compounds":"2-dehydropantoate + H(+) + NADPH => (R)-pantoate + NADP(+)"}
{"X":19362,"RHEA_ID":26176,"DIRECTION":"UN","MASTER_ID":26176,"ec":"6.3.1.13","compounds":"1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + ATP + L-cysteine = 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + H(+)"}
{"X":19363,"RHEA_ID":16237,"DIRECTION":"UN","MASTER_ID":16237,"ec":"5.2.1.8","compounds":"[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)"}
{"X":19364,"RHEA_ID":16238,"compounds":"[protein]-peptidylproline (omega=180) => [protein]-peptidylproline (omega=0)"}
{"X":19365,"RHEA_ID":16239,"compounds":"[protein]-peptidylproline (omega=0) => [protein]-peptidylproline (omega=180)"}
{"X":19366,"RHEA_ID":16241,"DIRECTION":"UN","MASTER_ID":16241,"ec":"2.4.1.13","compounds":"an NDP-alpha-D-glucose + D-fructose = a ribonucleoside 5'-diphosphate + H(+) + sucrose"}
{"X":19367,"RHEA_ID":16242,"DIRECTION":"LR","MASTER_ID":16241,"metacyc":"RXN-6222","compounds":"an NDP-alpha-D-glucose + D-fructose => a ribonucleoside 5'-diphosphate + H(+) + sucrose"}
{"X":19368,"RHEA_ID":16243,"compounds":"a ribonucleoside 5'-diphosphate + H(+) + sucrose => an NDP-alpha-D-glucose + D-fructose"}
{"X":19369,"RHEA_ID":26184,"compounds":"1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H2O = 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + phosphate"}
{"X":19370,"RHEA_ID":16245,"DIRECTION":"UN","MASTER_ID":16245,"ec":"2.3.1.121","compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":19371,"RHEA_ID":16246,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":19372,"RHEA_ID":16247,"compounds":"1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA"}
{"X":19373,"RHEA_ID":16249,"DIRECTION":"UN","MASTER_ID":16249,"ec":"5.1.3.15","compounds":"alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate"}
{"X":19374,"RHEA_ID":16250,"compounds":"alpha-D-glucose 6-phosphate => beta-D-glucose 6-phosphate"}
{"X":19375,"RHEA_ID":16251,"compounds":"beta-D-glucose 6-phosphate => alpha-D-glucose 6-phosphate"}
{"X":19376,"RHEA_ID":26193,"DIRECTION":"UN","MASTER_ID":26193,"ec":"6.2.1.9","compounds":"(S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate"}
{"X":19377,"RHEA_ID":16253,"DIRECTION":"UN","MASTER_ID":16253,"ec":"1.3.1.49","compounds":"(3S,4R)-3,4-dihydrophenanthrene-3,4-diol + NAD(+) = H(+) + NADH + phenanthrene-3,4-diol"}
{"X":19378,"RHEA_ID":16254,"compounds":"(3S,4R)-3,4-dihydrophenanthrene-3,4-diol + NAD(+) => H(+) + NADH + phenanthrene-3,4-diol"}
{"X":19379,"RHEA_ID":16255,"compounds":"H(+) + NADH + phenanthrene-3,4-diol => (3S,4R)-3,4-dihydrophenanthrene-3,4-diol + NAD(+)"}
{"X":19380,"RHEA_ID":26197,"DIRECTION":"UN","MASTER_ID":26197,"ec":"3.5.4.45","compounds":"H2O + melamine = ammeline + NH4(+)"}
{"X":19381,"RHEA_ID":16257,"DIRECTION":"UN","MASTER_ID":16257,"ec":"2.4.1.231","compounds":"alpha,alpha-trehalose + phosphate = alpha-D-glucose + alpha-D-glucose 1-phosphate"}
{"X":19382,"RHEA_ID":16258,"compounds":"alpha,alpha-trehalose + phosphate => alpha-D-glucose + alpha-D-glucose 1-phosphate"}
{"X":19383,"RHEA_ID":16259,"compounds":"alpha-D-glucose + alpha-D-glucose 1-phosphate => alpha,alpha-trehalose + phosphate"}
{"X":19384,"RHEA_ID":26201,"DIRECTION":"UN","MASTER_ID":26201,"ec":"3.5.4.45","compounds":"ammeline + H(+) + H2O = ammelide + NH4(+)"}
{"X":19385,"RHEA_ID":16261,"compounds":"L-lysyl-[protein] + succinyl-CoA = CoA + H(+) + N(6)-succinyl-L-lysyl-[protein]"}
{"X":19386,"RHEA_ID":16262,"compounds":"L-lysyl-[protein] + succinyl-CoA => CoA + H(+) + N(6)-succinyl-L-lysyl-[protein]"}
{"X":19387,"RHEA_ID":16263,"compounds":"CoA + H(+) + N(6)-succinyl-L-lysyl-[protein] => L-lysyl-[protein] + succinyl-CoA"}
{"X":19388,"RHEA_ID":16264,"compounds":"L-lysyl-[protein] + succinyl-CoA <=> CoA + H(+) + N(6)-succinyl-L-lysyl-[protein]"}
{"X":19389,"RHEA_ID":16265,"DIRECTION":"UN","MASTER_ID":16265,"ec":"1.14.14.96","compounds":"O2 + reduced [NADPH--hemoprotein reductase] + trans-5-O-(4-coumaroyl)-D-quinate = 5-O-[(E)-caffeoyl]-D-quinate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":19390,"RHEA_ID":16266,"DIRECTION":"LR","MASTER_ID":16265,"metacyc":"1.14.13.36-RXN","compounds":"O2 + reduced [NADPH--hemoprotein reductase] + trans-5-O-(4-coumaroyl)-D-quinate => 5-O-[(E)-caffeoyl]-D-quinate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":19391,"RHEA_ID":16267,"compounds":"5-O-[(E)-caffeoyl]-D-quinate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + trans-5-O-(4-coumaroyl)-D-quinate"}
{"X":19392,"RHEA_ID":26209,"DIRECTION":"UN","MASTER_ID":26209,"ec":"4.1.2.48","compounds":"L-allo-threonine = acetaldehyde + glycine"}
{"X":19393,"RHEA_ID":16269,"DIRECTION":"UN","MASTER_ID":16269,"ec":"1.7.1.6","compounds":"aniline + N,N-dimethyl-1,4-phenylenediamine + 2 NADP(+) = 4-(dimethylamino)azobenzene + 2 H(+) + 2 NADPH"}
{"X":19394,"RHEA_ID":16270,"compounds":"aniline + N,N-dimethyl-1,4-phenylenediamine + 2 NADP(+) => 4-(dimethylamino)azobenzene + 2 H(+) + 2 NADPH"}
{"X":19395,"RHEA_ID":16271,"compounds":"4-(dimethylamino)azobenzene + 2 H(+) + 2 NADPH => aniline + N,N-dimethyl-1,4-phenylenediamine + 2 NADP(+)"}
{"X":19396,"RHEA_ID":16273,"DIRECTION":"UN","MASTER_ID":16273,"ec":"2.7.8.3","metacyc":"CERAMIDE-CHOLINEPHOSPHOTRANSFERASE-RXN","compounds":"an N-acylsphing-4-enine + CDP-choline = CMP + H(+) + sphingomyelin"}
{"X":19397,"RHEA_ID":16274,"compounds":"an N-acylsphing-4-enine + CDP-choline => CMP + H(+) + sphingomyelin"}
{"X":19398,"RHEA_ID":16275,"compounds":"CMP + H(+) + sphingomyelin => an N-acylsphing-4-enine + CDP-choline"}
{"X":19399,"RHEA_ID":36775,"DIRECTION":"UN","MASTER_ID":36775,"ec":"2.4.1.309","compounds":"alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-di-trans,octa-cis-undecaprenol + UDP-alpha-D-galactose = alpha-D-Gal-(1->3)-[alpha-L-Fuc-(1->2)]-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-di-trans,octa-cis-undecaprenol + H(+) + UDP"}
{"X":19400,"RHEA_ID":16277,"DIRECTION":"UN","MASTER_ID":16277,"ec":"1.2.3.7","compounds":"H2O + indole-3-acetaldehyde + O2 = (indol-3-yl)acetate + H(+) + H2O2"}
{"X":19401,"RHEA_ID":16278,"DIRECTION":"LR","MASTER_ID":16277,"metacyc":"INDOLE-3-ACETALDEHYDE-OXIDASE-RXN","compounds":"H2O + indole-3-acetaldehyde + O2 => (indol-3-yl)acetate + H(+) + H2O2"}
{"X":19402,"RHEA_ID":16279,"compounds":"(indol-3-yl)acetate + H(+) + H2O2 => H2O + indole-3-acetaldehyde + O2"}
{"X":19403,"RHEA_ID":36779,"DIRECTION":"UN","MASTER_ID":36779,"ec":"2.6.1.102","compounds":"2-oxoglutarate + GDP-alpha-D-perosamine = GDP-4-dehydro-alpha-D-rhamnose + L-glutamate"}
{"X":19404,"RHEA_ID":16281,"DIRECTION":"UN","MASTER_ID":16281,"ec":"2.7.1.88","metacyc":"2.7.1.88-RXN","compounds":"ATP + dihydrostreptomycin 6-phosphate = ADP + dihydrostreptomycin 3'alpha,6-bisphosphate + H(+)"}
{"X":19405,"RHEA_ID":16282,"compounds":"ATP + dihydrostreptomycin 6-phosphate => ADP + dihydrostreptomycin 3'alpha,6-bisphosphate + H(+)"}
{"X":19406,"RHEA_ID":16283,"compounds":"ADP + dihydrostreptomycin 3'alpha,6-bisphosphate + H(+) => ATP + dihydrostreptomycin 6-phosphate"}
{"X":19407,"RHEA_ID":36783,"DIRECTION":"UN","MASTER_ID":36783,"ec":"2.5.1.108","compounds":"L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine"}
{"X":19408,"RHEA_ID":16285,"DIRECTION":"UN","MASTER_ID":16285,"ec":"1.5.1.11","compounds":"D-octopine + H2O + NAD(+) = H(+) + L-arginine + NADH + pyruvate"}
{"X":19409,"RHEA_ID":16286,"compounds":"D-octopine + H2O + NAD(+) => H(+) + L-arginine + NADH + pyruvate"}
{"X":19410,"RHEA_ID":16287,"DIRECTION":"RL","MASTER_ID":16285,"metacyc":"1.5.1.11-RXN","compounds":"H(+) + L-arginine + NADH + pyruvate => D-octopine + H2O + NAD(+)"}
{"X":19411,"RHEA_ID":36787,"DIRECTION":"UN","MASTER_ID":36787,"ec":"2.7.8.40","compounds":"di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-galactosamine = N-acetyl-alpha-D-galactosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UMP"}
{"X":19412,"RHEA_ID":16289,"DIRECTION":"UN","MASTER_ID":16289,"ec":"1.5.1.18","metacyc":"EPHEDRINE-DEHYDROGENASE-RXN","compounds":"(1R,2S)-ephedrine + NAD(+) = (R)-2-methylimino-1-phenylpropan-1-ol + 2 H(+) + NADH"}
{"X":19413,"RHEA_ID":16290,"compounds":"(1R,2S)-ephedrine + NAD(+) => (R)-2-methylimino-1-phenylpropan-1-ol + 2 H(+) + NADH"}
{"X":19414,"RHEA_ID":16291,"compounds":"(R)-2-methylimino-1-phenylpropan-1-ol + 2 H(+) + NADH => (1R,2S)-ephedrine + NAD(+)"}
{"X":19415,"RHEA_ID":26232,"DIRECTION":"BI","MASTER_ID":26229,"metacyc":"RXN-10625","compounds":"3 NADP(+) + phytyl diphosphate <=> geranylgeranyl diphosphate + 3 H(+) + 3 NADPH"}
{"X":19416,"RHEA_ID":16293,"compounds":"2-isopropylmaleate + H2O = (2S)-2-isopropylmalate"}
{"X":19417,"RHEA_ID":16294,"compounds":"2-isopropylmaleate + H2O => (2S)-2-isopropylmalate"}
{"X":19418,"RHEA_ID":16295,"compounds":"(2S)-2-isopropylmalate => 2-isopropylmaleate + H2O"}
{"X":19419,"RHEA_ID":36795,"DIRECTION":"UN","MASTER_ID":36795,"ec":"3.6.1.5","compounds":"a ribonucleoside 5'-triphosphate + 2 H2O = a ribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate"}
{"X":19420,"RHEA_ID":16297,"DIRECTION":"UN","MASTER_ID":16297,"ec":"1.1.1.210","compounds":"5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH"}
{"X":19421,"RHEA_ID":16298,"compounds":"5alpha-androstane-3beta,17beta-diol + NADP(+) => 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH"}
{"X":19422,"RHEA_ID":16299,"compounds":"17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH => 5alpha-androstane-3beta,17beta-diol + NADP(+)"}
{"X":19423,"RHEA_ID":36799,"DIRECTION":"UN","MASTER_ID":36799,"ec":"3.6.1.6","compounds":"a ribonucleoside 5'-diphosphate + H2O = a ribonucleoside 5'-phosphate + H(+) + phosphate"}
{"X":19424,"RHEA_ID":16301,"DIRECTION":"UN","MASTER_ID":16301,"ec":"3.2.2.5","compounds":"H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide"}
{"X":19425,"RHEA_ID":16301,"DIRECTION":"UN","MASTER_ID":16301,"ec":"3.2.2.6","compounds":"H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide"}
{"X":19426,"RHEA_ID":16302,"DIRECTION":"LR","MASTER_ID":16301,"metacyc":"NADNUCLEOSID-RXN","reactome":"R-HSA-8938076.1","compounds":"H2O + NAD(+) => ADP-D-ribose + H(+) + nicotinamide"}
{"X":19427,"RHEA_ID":16302,"DIRECTION":"LR","MASTER_ID":16301,"metacyc":"NADNUCLEOSID-RXN","reactome":"R-HSA-8870346.2","compounds":"H2O + NAD(+) => ADP-D-ribose + H(+) + nicotinamide"}
{"X":19428,"RHEA_ID":16302,"DIRECTION":"LR","MASTER_ID":16301,"metacyc":"NADNUCLEOSID-RXN","reactome":"R-HSA-9637699.1","compounds":"H2O + NAD(+) => ADP-D-ribose + H(+) + nicotinamide"}
{"X":19429,"RHEA_ID":16303,"compounds":"ADP-D-ribose + H(+) + nicotinamide => H2O + NAD(+)"}
{"X":19430,"RHEA_ID":26247,"compounds":"diphosphate + fusicocca-2,10(14)-diene => geranylgeranyl diphosphate"}
{"X":19431,"RHEA_ID":16305,"DIRECTION":"UN","MASTER_ID":16305,"ec":"3.1.2.27","compounds":"(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+)"}
{"X":19432,"RHEA_ID":16305,"DIRECTION":"UN","MASTER_ID":16305,"ec":"3.1.2.5","compounds":"(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+)"}
{"X":19433,"RHEA_ID":16306,"DIRECTION":"LR","MASTER_ID":16305,"metacyc":"HYDROXYMETHYLGLUTARYL-COA-HYDROLASE-RXN","compounds":"(3S)-hydroxy-3-methylglutaryl-CoA + H2O => 3-hydroxy-3-methylglutarate + CoA + H(+)"}
{"X":19434,"RHEA_ID":16307,"compounds":"3-hydroxy-3-methylglutarate + CoA + H(+) => (3S)-hydroxy-3-methylglutaryl-CoA + H2O"}
{"X":19435,"RHEA_ID":26252,"compounds":"H(+) + levopimaradienol + NADPH + O2 <=> 2 H2O + levopimaradienal + NADP(+)"}
{"X":19436,"RHEA_ID":16309,"DIRECTION":"UN","MASTER_ID":16309,"ec":"3.5.1.74","compounds":"H2O + taurochenodeoxycholate = chenodeoxycholate + taurine"}
{"X":19437,"RHEA_ID":16310,"DIRECTION":"LR","MASTER_ID":16309,"metacyc":"CHENODEOXYCHOLOYLTAURINE-HYDROLASE-RXN","compounds":"H2O + taurochenodeoxycholate => chenodeoxycholate + taurine"}
{"X":19438,"RHEA_ID":16311,"compounds":"chenodeoxycholate + taurine => H2O + taurochenodeoxycholate"}
{"X":19439,"RHEA_ID":26256,"compounds":"H(+) + isopimara-7,15-dienol + NADPH + O2 <=> 2 H2O + isopimara-7,15-dienal + NADP(+)"}
{"X":19440,"RHEA_ID":16313,"DIRECTION":"UN","MASTER_ID":16313,"ec":"3.1.1.66","compounds":"5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene + H2O = 5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene + acetate + H(+)"}
{"X":19441,"RHEA_ID":16314,"DIRECTION":"LR","MASTER_ID":16313,"metacyc":"3.1.1.66-RXN","compounds":"5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene + H2O => 5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene + acetate + H(+)"}
{"X":19442,"RHEA_ID":16315,"compounds":"5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene + acetate + H(+) => 5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene + H2O"}
{"X":19443,"RHEA_ID":26260,"compounds":"dehydroabietadienol + H(+) + NADPH + O2 <=> dehydroabietadienal + 2 H2O + NADP(+)"}
{"X":19444,"RHEA_ID":16317,"DIRECTION":"UN","MASTER_ID":16317,"ec":"1.1.1.112","compounds":"indan-1-ol + NAD(+) = H(+) + indan-1-one + NADH"}
{"X":19445,"RHEA_ID":16318,"compounds":"indan-1-ol + NAD(+) => H(+) + indan-1-one + NADH"}
{"X":19446,"RHEA_ID":16319,"compounds":"H(+) + indan-1-one + NADH => indan-1-ol + NAD(+)"}
{"X":19447,"RHEA_ID":26264,"compounds":"H2O + isopimara-7,15-dienal + NADP(+) <=> 2 H(+) + isopimarate + NADPH"}
{"X":19448,"RHEA_ID":16321,"DIRECTION":"UN","MASTER_ID":16321,"ec":"1.1.1.112","compounds":"indan-1-ol + NADP(+) = H(+) + indan-1-one + NADPH"}
{"X":19449,"RHEA_ID":16322,"compounds":"indan-1-ol + NADP(+) => H(+) + indan-1-one + NADPH"}
{"X":19450,"RHEA_ID":16323,"compounds":"H(+) + indan-1-one + NADPH => indan-1-ol + NADP(+)"}
{"X":19451,"RHEA_ID":26268,"compounds":"dehydroabietadienal + H2O + NADP(+) <=> dehydroabietate + 2 H(+) + NADPH"}
{"X":19452,"RHEA_ID":16325,"DIRECTION":"UN","MASTER_ID":16325,"ec":"2.7.7.44","compounds":"1-phospho-alpha-D-glucuronate + H(+) + UTP = diphosphate + UDP-alpha-D-glucuronate"}
{"X":19453,"RHEA_ID":16326,"compounds":"1-phospho-alpha-D-glucuronate + H(+) + UTP => diphosphate + UDP-alpha-D-glucuronate"}
{"X":19454,"RHEA_ID":16327,"compounds":"diphosphate + UDP-alpha-D-glucuronate => 1-phospho-alpha-D-glucuronate + H(+) + UTP"}
{"X":19455,"RHEA_ID":26272,"compounds":"Co-precorrin-2 + 3 H(+) <=> Co(2+) + precorrin-2"}
{"X":19456,"RHEA_ID":16329,"compounds":"(9Z,12Z,15Z)-octadecatrienoate + O2 = (R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate"}
{"X":19457,"RHEA_ID":16330,"compounds":"(9Z,12Z,15Z)-octadecatrienoate + O2 => (R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate"}
{"X":19458,"RHEA_ID":16331,"compounds":"(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2"}
{"X":19459,"RHEA_ID":16332,"compounds":"(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate"}
{"X":19460,"RHEA_ID":16333,"DIRECTION":"UN","MASTER_ID":16333,"ec":"2.7.7.61","compounds":"2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[citrate lyase ACP] = diphosphate + holo-[citrate lyase ACP]"}
{"X":19461,"RHEA_ID":16334,"DIRECTION":"LR","MASTER_ID":16333,"ecocyc":"2.7.7.61-RXN","metacyc":"2.7.7.61-RXN","compounds":"2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[citrate lyase ACP] => diphosphate + holo-[citrate lyase ACP]"}
{"X":19462,"RHEA_ID":16335,"compounds":"diphosphate + holo-[citrate lyase ACP] => 2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[citrate lyase ACP]"}
{"X":19463,"RHEA_ID":16337,"DIRECTION":"UN","MASTER_ID":16337,"ec":"1.14.14.82","compounds":"a 3'-unsubstituted flavone + O2 + reduced [NADPH--hemoprotein reductase] = a 3'-hydroxyflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":19464,"RHEA_ID":16338,"DIRECTION":"LR","MASTER_ID":16337,"metacyc":"FLAVONOID-3-MONOOXYGENASE-RXN","compounds":"a 3'-unsubstituted flavone + O2 + reduced [NADPH--hemoprotein reductase] => a 3'-hydroxyflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":19465,"RHEA_ID":16339,"compounds":"a 3'-hydroxyflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 3'-unsubstituted flavone + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":19466,"RHEA_ID":16341,"DIRECTION":"UN","MASTER_ID":16341,"ec":"2.7.4.2","compounds":"(R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP"}
{"X":19467,"RHEA_ID":16342,"DIRECTION":"LR","MASTER_ID":16341,"reactome":"R-HSA-191422.1","compounds":"(R)-5-phosphomevalonate + ATP => (R)-5-diphosphomevalonate + ADP"}
{"X":19468,"RHEA_ID":16343,"compounds":"(R)-5-diphosphomevalonate + ADP => (R)-5-phosphomevalonate + ATP"}
{"X":19469,"RHEA_ID":36847,"DIRECTION":"UN","MASTER_ID":36847,"ec":"2.7.1.180","compounds":"FAD + L-threonyl-[protein] = AMP + FMN-L-threonyl-[protein] + H(+)"}
{"X":19470,"RHEA_ID":16345,"DIRECTION":"UN","MASTER_ID":16345,"ec":"4.2.3.167","compounds":"all-trans-geranylgeranyl diphosphate + H2O = (3E,7E)-dolabella-3,7-dien-18-ol + diphosphate"}
{"X":19471,"RHEA_ID":16346,"DIRECTION":"LR","MASTER_ID":16345,"metacyc":"RXN-18811","compounds":"all-trans-geranylgeranyl diphosphate + H2O => (3E,7E)-dolabella-3,7-dien-18-ol + diphosphate"}
{"X":19472,"RHEA_ID":16347,"compounds":"(3E,7E)-dolabella-3,7-dien-18-ol + diphosphate => all-trans-geranylgeranyl diphosphate + H2O"}
{"X":19473,"RHEA_ID":36851,"compounds":"(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + CO2 + CoA"}
{"X":19474,"RHEA_ID":16349,"DIRECTION":"UN","MASTER_ID":16349,"ec":"1.97.1.1","compounds":"AH2 + chlorate = A + chlorite + H2O"}
{"X":19475,"RHEA_ID":16350,"DIRECTION":"LR","MASTER_ID":16349,"metacyc":"1.97.1.1-RXN","compounds":"AH2 + chlorate => A + chlorite + H2O"}
{"X":19476,"RHEA_ID":16351,"compounds":"A + chlorite + H2O => AH2 + chlorate"}
{"X":19477,"RHEA_ID":16353,"DIRECTION":"UN","MASTER_ID":16353,"ec":"2.6.1.55","compounds":"2-oxoglutarate + taurine = L-glutamate + sulfoacetaldehyde"}
{"X":19478,"RHEA_ID":16354,"compounds":"2-oxoglutarate + taurine => L-glutamate + sulfoacetaldehyde"}
{"X":19479,"RHEA_ID":16355,"compounds":"L-glutamate + sulfoacetaldehyde => 2-oxoglutarate + taurine"}
{"X":19480,"RHEA_ID":36858,"DIRECTION":"BI","MASTER_ID":36855,"metacyc":"RXN-13684","compounds":"an N-acetyl-L-cysteine-S-conjugate + H2O <=> acetate + an S-substituted L-cysteine"}
{"X":19481,"RHEA_ID":16357,"compounds":"A + succinate = AH2 + fumarate"}
{"X":19482,"RHEA_ID":16358,"compounds":"A + succinate => AH2 + fumarate"}
{"X":19483,"RHEA_ID":16359,"compounds":"AH2 + fumarate => A + succinate"}
{"X":19484,"RHEA_ID":36862,"compounds":"(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + CO2 + CoA"}
{"X":19485,"RHEA_ID":16361,"DIRECTION":"UN","MASTER_ID":16361,"ec":"5.4.99.3","compounds":"2-acetolactate = 3-hydroxy-3-methyl-2-oxobutanoate"}
{"X":19486,"RHEA_ID":16362,"compounds":"2-acetolactate => 3-hydroxy-3-methyl-2-oxobutanoate"}
{"X":19487,"RHEA_ID":16363,"compounds":"3-hydroxy-3-methyl-2-oxobutanoate => 2-acetolactate"}
{"X":19488,"RHEA_ID":36866,"compounds":"(9Z)-octadecenoyl-CoA + AH2 + O2 <=> (9Z,12Z)-octadecadienoyl-CoA + A + 2 H2O"}
{"X":19489,"RHEA_ID":16365,"DIRECTION":"UN","MASTER_ID":16365,"ec":"3.1.1.20","compounds":"digallate + H2O = 2 3,4,5-trihydroxybenzoate + H(+)"}
{"X":19490,"RHEA_ID":16366,"DIRECTION":"LR","MASTER_ID":16365,"metacyc":"TANNASE-RXN","compounds":"digallate + H2O => 2 3,4,5-trihydroxybenzoate + H(+)"}
{"X":19491,"RHEA_ID":16367,"compounds":"2 3,4,5-trihydroxybenzoate + H(+) => digallate + H2O"}
{"X":19492,"RHEA_ID":36870,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AH2 + O2 <=> (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + A + 2 H2O"}
{"X":19493,"RHEA_ID":16369,"DIRECTION":"UN","MASTER_ID":16369,"ec":"1.1.1.28","compounds":"(R)-lactate + NAD(+) = H(+) + NADH + pyruvate"}
{"X":19494,"RHEA_ID":16370,"compounds":"(R)-lactate + NAD(+) => H(+) + NADH + pyruvate"}
{"X":19495,"RHEA_ID":16371,"DIRECTION":"RL","MASTER_ID":16369,"ecocyc":"DLACTDEHYDROGNAD-RXN","metacyc":"DLACTDEHYDROGNAD-RXN","compounds":"H(+) + NADH + pyruvate => (R)-lactate + NAD(+)"}
{"X":19496,"RHEA_ID":16373,"DIRECTION":"UN","MASTER_ID":16373,"ec":"2.7.1.33","compounds":"(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)"}
{"X":19497,"RHEA_ID":16374,"DIRECTION":"LR","MASTER_ID":16373,"ecocyc":"PANTOTHENATE-KIN-RXN","metacyc":"PANTOTHENATE-KIN-RXN","compounds":"(R)-pantothenate + ATP => (R)-4'-phosphopantothenate + ADP + H(+)"}
{"X":19498,"RHEA_ID":16375,"compounds":"(R)-4'-phosphopantothenate + ADP + H(+) => (R)-pantothenate + ATP"}
{"X":19499,"RHEA_ID":36878,"compounds":"(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + CO2 + CoA"}
{"X":19500,"RHEA_ID":16377,"DIRECTION":"UN","MASTER_ID":16377,"ec":"1.3.7.4","compounds":"(3Z)-phytochromobilin + 2 oxidized [2Fe-2S]-[ferredoxin] = biliverdin IXalpha + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":19501,"RHEA_ID":16378,"compounds":"(3Z)-phytochromobilin + 2 oxidized [2Fe-2S]-[ferredoxin] => biliverdin IXalpha + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":19502,"RHEA_ID":16379,"DIRECTION":"RL","MASTER_ID":16377,"metacyc":"1.3.7.4-RXN","compounds":"biliverdin IXalpha + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => (3Z)-phytochromobilin + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":19503,"RHEA_ID":26324,"compounds":"resorcinol + S-adenosyl-L-methionine <=> 3-methoxyphenol + H(+) + S-adenosyl-L-homocysteine"}
{"X":19504,"RHEA_ID":16381,"DIRECTION":"UN","MASTER_ID":16381,"ec":"1.1.1.12","compounds":"L-arabinitol + NAD(+) = H(+) + L-xylulose + NADH"}
{"X":19505,"RHEA_ID":16382,"compounds":"L-arabinitol + NAD(+) => H(+) + L-xylulose + NADH"}
{"X":19506,"RHEA_ID":16383,"compounds":"H(+) + L-xylulose + NADH => L-arabinitol + NAD(+)"}
{"X":19507,"RHEA_ID":26328,"compounds":"(8Z,11Z)-5-(pentadeca-8,11,14-trien-1-yl)resorcinol + S-adenosyl-L-methionine <=> (8Z,11Z)-5-(pentadeca- 8,11,14-trien-1-yl)resorcinol-3-methyl ether + H(+) + S-adenosyl-L-homocysteine"}
{"X":19508,"RHEA_ID":16385,"DIRECTION":"UN","MASTER_ID":16385,"ec":"1.14.13.64","compounds":"4-hydroxybenzoate + 2 H(+) + NADPH + O2 = CO2 + H2O + hydroquinone + NADP(+)"}
{"X":19509,"RHEA_ID":16386,"DIRECTION":"LR","MASTER_ID":16385,"metacyc":"1.14.13.64-RXN","compounds":"4-hydroxybenzoate + 2 H(+) + NADPH + O2 => CO2 + H2O + hydroquinone + NADP(+)"}
{"X":19510,"RHEA_ID":16387,"compounds":"CO2 + H2O + hydroquinone + NADP(+) => 4-hydroxybenzoate + 2 H(+) + NADPH + O2"}
{"X":19511,"RHEA_ID":36890,"compounds":"(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + AH2 + O2 <=> (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + A + 2 H2O"}
{"X":19512,"RHEA_ID":16389,"DIRECTION":"UN","MASTER_ID":16389,"ec":"1.14.13.64","compounds":"4-hydroxybenzoate + 2 H(+) + NADH + O2 = CO2 + H2O + hydroquinone + NAD(+)"}
{"X":19513,"RHEA_ID":16390,"DIRECTION":"LR","MASTER_ID":16389,"metacyc":"1.14.13.64-RXN","compounds":"4-hydroxybenzoate + 2 H(+) + NADH + O2 => CO2 + H2O + hydroquinone + NAD(+)"}
{"X":19514,"RHEA_ID":16391,"compounds":"CO2 + H2O + hydroquinone + NAD(+) => 4-hydroxybenzoate + 2 H(+) + NADH + O2"}
{"X":19515,"RHEA_ID":26336,"compounds":"2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + cyclic pyranopterin phosphate + H2O <=> 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 4 H(+) + molybdopterin"}
{"X":19516,"RHEA_ID":16393,"DIRECTION":"UN","MASTER_ID":16393,"ec":"3.1.1.59","compounds":"H2O + juvenile hormone II = H(+) + juvenile hormone II carboxylate + methanol"}
{"X":19517,"RHEA_ID":16394,"DIRECTION":"LR","MASTER_ID":16393,"metacyc":"JUVENILE-HORMONE-ESTERASE-RXN","compounds":"H2O + juvenile hormone II => H(+) + juvenile hormone II carboxylate + methanol"}
{"X":19518,"RHEA_ID":16395,"compounds":"H(+) + juvenile hormone II carboxylate + methanol => H2O + juvenile hormone II"}
{"X":19519,"RHEA_ID":36898,"compounds":"(9Z,12Z,15Z)-octadecatrienoyl-CoA + AH2 + O2 <=> (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + A + 2 H2O"}
{"X":19520,"RHEA_ID":16397,"DIRECTION":"UN","MASTER_ID":16397,"ec":"2.7.1.41","metacyc":"GLUCOSE-1-PHOSPHATE-PHOSPHODISMUTASE-RXN","compounds":"2 D-glucopyranose 1-phosphate = D-glucose + D-glucose 1,6-bisphosphate"}
{"X":19521,"RHEA_ID":16398,"compounds":"2 D-glucopyranose 1-phosphate => D-glucose + D-glucose 1,6-bisphosphate"}
{"X":19522,"RHEA_ID":16399,"compounds":"D-glucose + D-glucose 1,6-bisphosphate => 2 D-glucopyranose 1-phosphate"}
{"X":19523,"RHEA_ID":46806,"compounds":"a 9-methyl-(4E,8E)-sphinga-4,8-dienine ceramide + H(+) + S-adenosyl-L-homocysteine => a (4E,8E)-4-sphinga-4,8-dienine ceramide + S-adenosyl-L-methionine"}
{"X":19524,"RHEA_ID":16405,"DIRECTION":"UN","MASTER_ID":16405,"ec":"1.1.1.217","metacyc":"1.1.1.217-RXN","compounds":"benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP(+) = benzyl 2-methyl-3-oxobutanoate + H(+) + NADPH"}
{"X":19525,"RHEA_ID":16406,"compounds":"benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP(+) => benzyl 2-methyl-3-oxobutanoate + H(+) + NADPH"}
{"X":19526,"RHEA_ID":16407,"compounds":"benzyl 2-methyl-3-oxobutanoate + H(+) + NADPH => benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP(+)"}
{"X":19527,"RHEA_ID":46810,"compounds":"[trehalose-6-phosphate synthase]-S-methyl-L-cysteine + H(+) + S-adenosyl-L-homocysteine => [trehalose-6-phosphate synthase]-L-cysteine + S-adenosyl-L-methionine"}
{"X":19528,"RHEA_ID":16409,"DIRECTION":"UN","MASTER_ID":16409,"ec":"1.5.1.32","compounds":"1,2-dihydrovomilenine + NADP(+) = H(+) + NADPH + vomilenine"}
{"X":19529,"RHEA_ID":16410,"compounds":"1,2-dihydrovomilenine + NADP(+) => H(+) + NADPH + vomilenine"}
{"X":19530,"RHEA_ID":16411,"DIRECTION":"RL","MASTER_ID":16409,"metacyc":"1.5.1.32-RXN","compounds":"H(+) + NADPH + vomilenine => 1,2-dihydrovomilenine + NADP(+)"}
{"X":19531,"RHEA_ID":36910,"compounds":"(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + malonyl-CoA <=> (13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + CO2 + CoA"}
{"X":19532,"RHEA_ID":16413,"DIRECTION":"UN","MASTER_ID":16413,"ec":"2.3.1.200","compounds":"[lipoyl-carrier protein]-L-lysine + N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] = [glycine-cleavage complex H protein]-L-lysine + [lipoyl-carrier protein]-(R)-N(6)-lipoyl-L-lysine"}
{"X":19533,"RHEA_ID":16414,"compounds":"[lipoyl-carrier protein]-L-lysine + N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] => [glycine-cleavage complex H protein]-L-lysine + [lipoyl-carrier protein]-(R)-N(6)-lipoyl-L-lysine"}
{"X":19534,"RHEA_ID":16415,"compounds":"[glycine-cleavage complex H protein]-L-lysine + [lipoyl-carrier protein]-(R)-N(6)-lipoyl-L-lysine => [lipoyl-carrier protein]-L-lysine + N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein]"}
{"X":19535,"RHEA_ID":16416,"DIRECTION":"BI","MASTER_ID":16413,"metacyc":"RXN-13032","compounds":"[lipoyl-carrier protein]-L-lysine + N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] <=> [glycine-cleavage complex H protein]-L-lysine + [lipoyl-carrier protein]-(R)-N(6)-lipoyl-L-lysine"}
{"X":19536,"RHEA_ID":16417,"DIRECTION":"UN","MASTER_ID":16417,"ec":"1.2.1.88","compounds":"(S)-1-pyrroline-5-carboxylate + 2 H2O + NAD(+) = H(+) + L-glutamate + NADH"}
{"X":19537,"RHEA_ID":16418,"DIRECTION":"LR","MASTER_ID":16417,"ecocyc":"PYRROLINECARBDEHYDROG-RXN","metacyc":"PYRROLINECARBDEHYDROG-RXN","compounds":"(S)-1-pyrroline-5-carboxylate + 2 H2O + NAD(+) => H(+) + L-glutamate + NADH"}
{"X":19538,"RHEA_ID":16419,"compounds":"H(+) + L-glutamate + NADH => (S)-1-pyrroline-5-carboxylate + 2 H2O + NAD(+)"}
{"X":19539,"RHEA_ID":26376,"compounds":"[thioredoxin]-disulfide + prostamide F2alpha <=> [thioredoxin]-dithiol + prostamide H2"}
{"X":19540,"RHEA_ID":16421,"DIRECTION":"UN","MASTER_ID":16421,"ec":"1.2.7.5","metacyc":"1.2.7.5-RXN","compounds":"an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":19541,"RHEA_ID":16422,"compounds":"an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":19542,"RHEA_ID":16423,"compounds":"a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":19543,"RHEA_ID":16425,"DIRECTION":"UN","MASTER_ID":16425,"ec":"1.2.1.46","compounds":"formaldehyde + H2O + NAD(+) = formate + 2 H(+) + NADH"}
{"X":19544,"RHEA_ID":16426,"DIRECTION":"LR","MASTER_ID":16425,"metacyc":"FORMALDEHYDE-DEHYDROGENASE-RXN","compounds":"formaldehyde + H2O + NAD(+) => formate + 2 H(+) + NADH"}
{"X":19545,"RHEA_ID":16427,"compounds":"formate + 2 H(+) + NADH => formaldehyde + H2O + NAD(+)"}
{"X":19546,"RHEA_ID":16429,"DIRECTION":"UN","MASTER_ID":16429,"ec":"6.3.2.9","compounds":"ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate"}
{"X":19547,"RHEA_ID":16430,"DIRECTION":"LR","MASTER_ID":16429,"ecocyc":"UDP-NACMURALA-GLU-LIG-RXN","metacyc":"UDP-NACMURALA-GLU-LIG-RXN","compounds":"ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate"}
{"X":19548,"RHEA_ID":16431,"compounds":"ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate => ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine"}
{"X":19549,"RHEA_ID":36930,"compounds":"(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + CO2 + CoA"}
{"X":19550,"RHEA_ID":16433,"compounds":"acetyl-CoA + N-terminal L-alanyl-[ribosomal protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein]"}
{"X":19551,"RHEA_ID":16434,"compounds":"acetyl-CoA + N-terminal L-alanyl-[ribosomal protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein]"}
{"X":19552,"RHEA_ID":16435,"compounds":"CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein] => acetyl-CoA + N-terminal L-alanyl-[ribosomal protein]"}
{"X":19553,"RHEA_ID":36934,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 <=> (9Z)-hexadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":19554,"RHEA_ID":16437,"DIRECTION":"UN","MASTER_ID":16437,"ec":"2.5.1.18","compounds":"glutathione + RX = a halide anion + an S-substituted glutathione + H(+)"}
{"X":19555,"RHEA_ID":16438,"DIRECTION":"LR","MASTER_ID":16437,"metacyc":"GSHTRAN-RXN","compounds":"glutathione + RX => a halide anion + an S-substituted glutathione + H(+)"}
{"X":19556,"RHEA_ID":16439,"compounds":"a halide anion + an S-substituted glutathione + H(+) => glutathione + RX"}
{"X":19557,"RHEA_ID":16441,"DIRECTION":"UN","MASTER_ID":16441,"ec":"3.5.1.44","compounds":"H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+)"}
{"X":19558,"RHEA_ID":16442,"DIRECTION":"LR","MASTER_ID":16441,"ecocyc":"CHEBDEAMID-RXN","metacyc":"CHEBDEAMID-RXN","compounds":"H2O + L-glutaminyl-[protein] => L-glutamyl-[protein] + NH4(+)"}
{"X":19559,"RHEA_ID":16443,"compounds":"L-glutamyl-[protein] + NH4(+) => H2O + L-glutaminyl-[protein]"}
{"X":19560,"RHEA_ID":16445,"DIRECTION":"UN","MASTER_ID":16445,"ec":"4.2.1.105","compounds":"(2R,3S)-2,4',7-trihydroxyisoflavanone = daidzein + H(+) + H2O"}
{"X":19561,"RHEA_ID":16446,"DIRECTION":"LR","MASTER_ID":16445,"metacyc":"RXN-3284","compounds":"(2R,3S)-2,4',7-trihydroxyisoflavanone => daidzein + H(+) + H2O"}
{"X":19562,"RHEA_ID":16447,"compounds":"daidzein + H(+) + H2O => (2R,3S)-2,4',7-trihydroxyisoflavanone"}
{"X":19563,"RHEA_ID":36946,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CO2 + CoA"}
{"X":19564,"RHEA_ID":16449,"DIRECTION":"UN","MASTER_ID":16449,"ec":"2.3.1.82","compounds":"acetyl-CoA + kanamycin B = CoA + H(+) + N(6')-acetylkanamycin B"}
{"X":19565,"RHEA_ID":16450,"compounds":"acetyl-CoA + kanamycin B => CoA + H(+) + N(6')-acetylkanamycin B"}
{"X":19566,"RHEA_ID":16451,"compounds":"CoA + H(+) + N(6')-acetylkanamycin B => acetyl-CoA + kanamycin B"}
{"X":19567,"RHEA_ID":36950,"compounds":"(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + CO2 + CoA"}
{"X":19568,"RHEA_ID":16453,"DIRECTION":"UN","MASTER_ID":16453,"ec":"4.1.2.34","compounds":"(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H2O = 2-formylbenzoate + pyruvate"}
{"X":19569,"RHEA_ID":16454,"compounds":"(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H2O => 2-formylbenzoate + pyruvate"}
{"X":19570,"RHEA_ID":16455,"compounds":"2-formylbenzoate + pyruvate => (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H2O"}
{"X":19571,"RHEA_ID":36954,"compounds":"AH2 + heptadecanoyl-CoA + O2 <=> (9Z)-heptadecenoyl-CoA + A + 2 H2O"}
{"X":19572,"RHEA_ID":16457,"DIRECTION":"UN","MASTER_ID":16457,"ec":"1.1.1.93","compounds":"(2R,3S)-tartrate + NAD(+) = 2-hydroxy-3-oxosuccinate + H(+) + NADH"}
{"X":19573,"RHEA_ID":16458,"compounds":"(2R,3S)-tartrate + NAD(+) => 2-hydroxy-3-oxosuccinate + H(+) + NADH"}
{"X":19574,"RHEA_ID":16459,"compounds":"2-hydroxy-3-oxosuccinate + H(+) + NADH => (2R,3S)-tartrate + NAD(+)"}
{"X":19575,"RHEA_ID":16461,"compounds":"ATP + H2O + urate(in) = ADP + H(+) + phosphate + urate(out)"}
{"X":19576,"RHEA_ID":16462,"compounds":"ATP + H2O + urate(in) => ADP + H(+) + phosphate + urate(out)"}
{"X":19577,"RHEA_ID":16463,"compounds":"ADP + H(+) + phosphate + urate(out) => ATP + H2O + urate(in)"}
{"X":19578,"RHEA_ID":16464,"compounds":"ATP + H2O + urate(in) <=> ADP + H(+) + phosphate + urate(out)"}
{"X":19579,"RHEA_ID":16465,"DIRECTION":"UN","MASTER_ID":16465,"ec":"1.1.2.5","compounds":"(R)-lactate + 2 [Fe(III)cytochrome c553] = 2 [Fe(II)cytochrome c553] + 2 H(+) + pyruvate"}
{"X":19580,"RHEA_ID":16466,"compounds":"(R)-lactate + 2 [Fe(III)cytochrome c553] => 2 [Fe(II)cytochrome c553] + 2 H(+) + pyruvate"}
{"X":19581,"RHEA_ID":16467,"compounds":"2 [Fe(II)cytochrome c553] + 2 H(+) + pyruvate => (R)-lactate + 2 [Fe(III)cytochrome c553]"}
{"X":19582,"RHEA_ID":16469,"DIRECTION":"UN","MASTER_ID":16469,"ec":"2.8.3.15","compounds":"(R)-2-benzylsuccinate + succinyl-CoA = (R)-2-benzylsuccinyl-CoA + succinate"}
{"X":19583,"RHEA_ID":16470,"compounds":"(R)-2-benzylsuccinate + succinyl-CoA => (R)-2-benzylsuccinyl-CoA + succinate"}
{"X":19584,"RHEA_ID":16471,"compounds":"(R)-2-benzylsuccinyl-CoA + succinate => (R)-2-benzylsuccinate + succinyl-CoA"}
{"X":19585,"RHEA_ID":26428,"compounds":"ADP + CTP + 2 H(+) + L-glutamate + phosphate => ATP + H2O + L-glutamine + UTP"}
{"X":19586,"RHEA_ID":16473,"DIRECTION":"UN","MASTER_ID":16473,"ec":"3.7.1.10","compounds":"cyclohexane-1,3-dione + H2O = 5-oxohexanoate + H(+)"}
{"X":19587,"RHEA_ID":16474,"DIRECTION":"LR","MASTER_ID":16473,"metacyc":"CYCLOHEXANE-13-DIONE-HYDROLASE-RXN","compounds":"cyclohexane-1,3-dione + H2O => 5-oxohexanoate + H(+)"}
{"X":19588,"RHEA_ID":16475,"compounds":"5-oxohexanoate + H(+) => cyclohexane-1,3-dione + H2O"}
{"X":19589,"RHEA_ID":26432,"compounds":"diphosphate + phyllocladan-16alpha-ol => (+)-copalyl diphosphate + H2O"}
{"X":19590,"RHEA_ID":16477,"compounds":"NAD(+) + prostaglandin E1 = 15-oxo-prostaglandin E1 + H(+) + NADH"}
{"X":19591,"RHEA_ID":16478,"compounds":"NAD(+) + prostaglandin E1 => 15-oxo-prostaglandin E1 + H(+) + NADH"}
{"X":19592,"RHEA_ID":16479,"compounds":"15-oxo-prostaglandin E1 + H(+) + NADH => NAD(+) + prostaglandin E1"}
{"X":19593,"RHEA_ID":16480,"compounds":"NAD(+) + prostaglandin E1 <=> 15-oxo-prostaglandin E1 + H(+) + NADH"}
{"X":19594,"RHEA_ID":16481,"DIRECTION":"UN","MASTER_ID":16481,"ec":"2.5.1.43","compounds":"3 S-adenosyl-L-methionine = 3 H(+) + nicotianamine + 3 S-methyl-5'-thioadenosine"}
{"X":19595,"RHEA_ID":16482,"DIRECTION":"LR","MASTER_ID":16481,"metacyc":"2.5.1.43-RXN","compounds":"3 S-adenosyl-L-methionine => 3 H(+) + nicotianamine + 3 S-methyl-5'-thioadenosine"}
{"X":19596,"RHEA_ID":16483,"compounds":"3 H(+) + nicotianamine + 3 S-methyl-5'-thioadenosine => 3 S-adenosyl-L-methionine"}
{"X":19597,"RHEA_ID":26440,"DIRECTION":"RL","MASTER_ID":26438,"ecocyc":"RXN-8974","metacyc":"RXN-8974","compounds":"3-oxopropanoate + H(+) + NADPH => 3-hydroxypropanoate + NADP(+)"}
{"X":19598,"RHEA_ID":16485,"DIRECTION":"UN","MASTER_ID":16485,"ec":"6.3.4.8","compounds":"5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + imidazole-4-acetate = 1-(5-phosphoribosyl)imidazole-4-acetate + ADP + diphosphate + H(+) + phosphate"}
{"X":19599,"RHEA_ID":16486,"DIRECTION":"LR","MASTER_ID":16485,"metacyc":"6.3.4.8-RXN","compounds":"5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + imidazole-4-acetate => 1-(5-phosphoribosyl)imidazole-4-acetate + ADP + diphosphate + H(+) + phosphate"}
{"X":19600,"RHEA_ID":16487,"compounds":"1-(5-phosphoribosyl)imidazole-4-acetate + ADP + diphosphate + H(+) + phosphate => 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + imidazole-4-acetate"}
{"X":19601,"RHEA_ID":26444,"DIRECTION":"RL","MASTER_ID":26442,"metacyc":"RXN-11039","compounds":"a ubiquinol + acetaldehyde => a ubiquinone + ethanol"}
{"X":19602,"RHEA_ID":16489,"DIRECTION":"UN","MASTER_ID":16489,"ec":"3.2.1.118","compounds":"(R)-prunasin + H2O = D-glucose + mandelonitrile"}
{"X":19603,"RHEA_ID":16490,"DIRECTION":"LR","MASTER_ID":16489,"metacyc":"PRUNASIN-BETA-GLUCOSIDASE-RXN","compounds":"(R)-prunasin + H2O => D-glucose + mandelonitrile"}
{"X":19604,"RHEA_ID":16491,"compounds":"D-glucose + mandelonitrile => (R)-prunasin + H2O"}
{"X":19605,"RHEA_ID":26448,"compounds":"H(+) + malonyl-CoA + NADPH => 3-oxopropanoate + CoA + NADP(+)"}
{"X":19606,"RHEA_ID":16493,"DIRECTION":"UN","MASTER_ID":16493,"ec":"3.1.4.42","compounds":"glycerol 1,2-cyclic phosphate + H2O = glycerol 1-phosphate + H(+)"}
{"X":19607,"RHEA_ID":16494,"DIRECTION":"LR","MASTER_ID":16493,"metacyc":"3.1.4.42-RXN","compounds":"glycerol 1,2-cyclic phosphate + H2O => glycerol 1-phosphate + H(+)"}
{"X":19608,"RHEA_ID":16495,"compounds":"glycerol 1-phosphate + H(+) => glycerol 1,2-cyclic phosphate + H2O"}
{"X":19609,"RHEA_ID":26452,"DIRECTION":"RL","MASTER_ID":26450,"metacyc":"RXN-8891","compounds":"H(+) + NADPH + succinyl-CoA => CoA + NADP(+) + succinate semialdehyde"}
{"X":19610,"RHEA_ID":16497,"DIRECTION":"UN","MASTER_ID":16497,"ec":"2.1.1.181","compounds":"adenosine(1618) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(1618) in 23S rRNA + S-adenosyl-L-homocysteine"}
{"X":19611,"RHEA_ID":16498,"DIRECTION":"LR","MASTER_ID":16497,"ecocyc":"RXN-11596","metacyc":"RXN-11596","compounds":"adenosine(1618) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine(1618) in 23S rRNA + S-adenosyl-L-homocysteine"}
{"X":19612,"RHEA_ID":16499,"compounds":"H(+) + N(6)-methyladenosine(1618) in 23S rRNA + S-adenosyl-L-homocysteine => adenosine(1618) in 23S rRNA + S-adenosyl-L-methionine"}
{"X":19613,"RHEA_ID":26456,"DIRECTION":"RL","MASTER_ID":26454,"metacyc":"RXN-9087","compounds":"acryloyl-CoA + H(+) + NADPH => NADP(+) + propanoyl-CoA"}
{"X":19614,"RHEA_ID":16501,"DIRECTION":"UN","MASTER_ID":16501,"ec":"3.1.4.44","compounds":"H2O + sn-glycero-3-phospho-1D-myo-inositol = H(+) + myo-inositol + sn-glycerol 3-phosphate"}
{"X":19615,"RHEA_ID":16502,"DIRECTION":"LR","MASTER_ID":16501,"metacyc":"3.1.4.44-RXN","compounds":"H2O + sn-glycero-3-phospho-1D-myo-inositol => H(+) + myo-inositol + sn-glycerol 3-phosphate"}
{"X":19616,"RHEA_ID":16503,"compounds":"H(+) + myo-inositol + sn-glycerol 3-phosphate => H2O + sn-glycero-3-phospho-1D-myo-inositol"}
{"X":19617,"RHEA_ID":26460,"compounds":"acetaldehyde + FMN + 2 H(+) + H2O + nitrite => ethylnitronate + FMNH2 + O2"}
{"X":19618,"RHEA_ID":16505,"DIRECTION":"UN","MASTER_ID":16505,"ec":"4.1.3.40","compounds":"chorismate = 4-hydroxybenzoate + pyruvate"}
{"X":19619,"RHEA_ID":16506,"DIRECTION":"LR","MASTER_ID":16505,"ecocyc":"CHORPYRLY-RXN","metacyc":"CHORPYRLY-RXN","compounds":"chorismate => 4-hydroxybenzoate + pyruvate"}
{"X":19620,"RHEA_ID":16507,"compounds":"4-hydroxybenzoate + pyruvate => chorismate"}
{"X":19621,"RHEA_ID":26464,"compounds":"3-methyl-6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + H(+) + S-adenosyl-L-homocysteine => 6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + S-adenosyl-L-methionine"}
{"X":19622,"RHEA_ID":16509,"DIRECTION":"UN","MASTER_ID":16509,"ec":"4.1.1.2","compounds":"H(+) + oxalate = CO2 + formate"}
{"X":19623,"RHEA_ID":16510,"DIRECTION":"LR","MASTER_ID":16509,"macie":"M0231","compounds":"H(+) + oxalate => CO2 + formate"}
{"X":19624,"RHEA_ID":16511,"compounds":"CO2 + formate => H(+) + oxalate"}
{"X":19625,"RHEA_ID":16513,"DIRECTION":"UN","MASTER_ID":16513,"ec":"1.13.12.4","compounds":"(S)-lactate + O2 = acetate + CO2 + H2O"}
{"X":19626,"RHEA_ID":16514,"DIRECTION":"LR","MASTER_ID":16513,"metacyc":"LACTATE-2-MONOOXYGENASE-RXN","compounds":"(S)-lactate + O2 => acetate + CO2 + H2O"}
{"X":19627,"RHEA_ID":16515,"compounds":"acetate + CO2 + H2O => (S)-lactate + O2"}
{"X":19628,"RHEA_ID":16517,"DIRECTION":"UN","MASTER_ID":16517,"ec":"1.1.1.75","compounds":"(R)-1-aminopropan-2-ol + NAD(+) = aminoacetone + H(+) + NADH"}
{"X":19629,"RHEA_ID":16518,"compounds":"(R)-1-aminopropan-2-ol + NAD(+) => aminoacetone + H(+) + NADH"}
{"X":19630,"RHEA_ID":16519,"DIRECTION":"RL","MASTER_ID":16517,"ecocyc":"AMINOPROPDEHYDROG-RXN","metacyc":"AMINOPROPDEHYDROG-RXN","compounds":"aminoacetone + H(+) + NADH => (R)-1-aminopropan-2-ol + NAD(+)"}
{"X":19631,"RHEA_ID":16521,"DIRECTION":"UN","MASTER_ID":16521,"ec":"1.18.1.7","compounds":"H(+) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NADH + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":19632,"RHEA_ID":16521,"DIRECTION":"UN","MASTER_ID":16521,"ec":"1.18.1.3","compounds":"H(+) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NADH + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":19633,"RHEA_ID":16522,"compounds":"H(+) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] => NADH + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":19634,"RHEA_ID":16523,"compounds":"NADH + 2 oxidized [2Fe-2S]-[ferredoxin] => H(+) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":19635,"RHEA_ID":16525,"DIRECTION":"UN","MASTER_ID":16525,"ec":"2.7.1.58","compounds":"2-dehydro-3-deoxy-D-galactonate + ATP = 2-dehydro-3-deoxy-6-phospho-D-galactonate + ADP + H(+)"}
{"X":19636,"RHEA_ID":16525,"DIRECTION":"UN","MASTER_ID":16525,"ec":"2.7.1.178","compounds":"2-dehydro-3-deoxy-D-galactonate + ATP = 2-dehydro-3-deoxy-6-phospho-D-galactonate + ADP + H(+)"}
{"X":19637,"RHEA_ID":16526,"DIRECTION":"LR","MASTER_ID":16525,"ecocyc":"DEHYDDEOXGALACTKIN-RXN","metacyc":"DEHYDDEOXGALACTKIN-RXN","compounds":"2-dehydro-3-deoxy-D-galactonate + ATP => 2-dehydro-3-deoxy-6-phospho-D-galactonate + ADP + H(+)"}
{"X":19638,"RHEA_ID":16527,"compounds":"2-dehydro-3-deoxy-6-phospho-D-galactonate + ADP + H(+) => 2-dehydro-3-deoxy-D-galactonate + ATP"}
{"X":19639,"RHEA_ID":26487,"compounds":"H(+) + O-phospho-L-serine + sulfite => L-cysteate + phosphate"}
{"X":19640,"RHEA_ID":16529,"DIRECTION":"UN","MASTER_ID":16529,"ec":"2.7.7.5","compounds":"ADP + H(+) + sulfate = adenosine 5'-phosphosulfate + phosphate"}
{"X":19641,"RHEA_ID":16530,"compounds":"ADP + H(+) + sulfate => adenosine 5'-phosphosulfate + phosphate"}
{"X":19642,"RHEA_ID":16531,"DIRECTION":"RL","MASTER_ID":16529,"metacyc":"SULFATE-ADENYLYLTRANSFERASE-ADP-RXN","compounds":"adenosine 5'-phosphosulfate + phosphate => ADP + H(+) + sulfate"}
{"X":19643,"RHEA_ID":26491,"DIRECTION":"LR","MASTER_ID":26490,"metacyc":"RXN-11045","compounds":"a secondary nitroalkane + H2O + O2 => a ketone + H(+) + H2O2 + nitrite"}
{"X":19644,"RHEA_ID":16533,"DIRECTION":"UN","MASTER_ID":16533,"ec":"2.4.1.94","metacyc":"2.4.1.94-RXN","compounds":"L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + UDP"}
{"X":19645,"RHEA_ID":16534,"compounds":"L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + UDP"}
{"X":19646,"RHEA_ID":16535,"compounds":"H(+) + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + UDP => L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":19647,"RHEA_ID":26495,"DIRECTION":"LR","MASTER_ID":26494,"metacyc":"RXN-10842","compounds":"chloride + FADH2 + L-tryptophan + O2 => 7-chloro-L-tryptophan + FAD + 2 H2O"}
{"X":19648,"RHEA_ID":16537,"DIRECTION":"UN","MASTER_ID":16537,"ec":"3.1.3.76","compounds":"(9S,10S)-10-hydroxy-9-(phosphooxy)octadecanoate + H2O = (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate"}
{"X":19649,"RHEA_ID":16538,"DIRECTION":"LR","MASTER_ID":16537,"metacyc":"3.1.3.76-RXN","compounds":"(9S,10S)-10-hydroxy-9-(phosphooxy)octadecanoate + H2O => (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate"}
{"X":19650,"RHEA_ID":16539,"compounds":"(9S,10S)-9,10-dihydroxyoctadecanoate + phosphate => (9S,10S)-10-hydroxy-9-(phosphooxy)octadecanoate + H2O"}
{"X":19651,"RHEA_ID":26499,"DIRECTION":"LR","MASTER_ID":26498,"metacyc":"RXN-8208","compounds":"delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + UDP-alpha-D-glucose => delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP"}
{"X":19652,"RHEA_ID":16541,"DIRECTION":"UN","MASTER_ID":16541,"ec":"1.13.11.51","compounds":"9-cis-violaxanthin + O2 = (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin"}
{"X":19653,"RHEA_ID":16542,"DIRECTION":"LR","MASTER_ID":16541,"metacyc":"RXN-7974","compounds":"9-cis-violaxanthin + O2 => (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin"}
{"X":19654,"RHEA_ID":16543,"compounds":"(3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin => 9-cis-violaxanthin + O2"}
{"X":19655,"RHEA_ID":26503,"DIRECTION":"LR","MASTER_ID":26502,"metacyc":"RXN-8209","compounds":"delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP-alpha-D-glucose => 2 H(+) + ternatin C5 + UDP"}
{"X":19656,"RHEA_ID":16545,"DIRECTION":"UN","MASTER_ID":16545,"ec":"2.8.3.16","compounds":"formyl-CoA + oxalate = formate + oxalyl-CoA"}
{"X":19657,"RHEA_ID":16546,"DIRECTION":"LR","MASTER_ID":16545,"macie":"M0155","metacyc":"RXN0-1382","compounds":"formyl-CoA + oxalate => formate + oxalyl-CoA"}
{"X":19658,"RHEA_ID":16547,"compounds":"formate + oxalyl-CoA => formyl-CoA + oxalate"}
{"X":19659,"RHEA_ID":26507,"compounds":"(9Z)-octadecenamide + H2O => (9Z)-octadecenoate + NH4(+)"}
{"X":19660,"RHEA_ID":16553,"compounds":"aldehydo-D-ribose 5-phosphate + L-lysyl-[protein] = H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein]"}
{"X":19661,"RHEA_ID":16554,"compounds":"aldehydo-D-ribose 5-phosphate + L-lysyl-[protein] => H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein]"}
{"X":19662,"RHEA_ID":16555,"compounds":"H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein] => aldehydo-D-ribose 5-phosphate + L-lysyl-[protein]"}
{"X":19663,"RHEA_ID":16556,"compounds":"aldehydo-D-ribose 5-phosphate + L-lysyl-[protein] <=> H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein]"}
{"X":19664,"RHEA_ID":16557,"DIRECTION":"UN","MASTER_ID":16557,"ec":"4.1.1.45","compounds":"2-amino-3-carboxymuconate 6-semialdehyde + H(+) = 2-aminomuconate 6-semialdehyde + CO2"}
{"X":19665,"RHEA_ID":16558,"DIRECTION":"LR","MASTER_ID":16557,"metacyc":"AMINO-CARBOXYMUCONATE-SEMIALDEHYDE-RXN","reactome":"R-HSA-71223.2","compounds":"2-amino-3-carboxymuconate 6-semialdehyde + H(+) => 2-aminomuconate 6-semialdehyde + CO2"}
{"X":19666,"RHEA_ID":16559,"compounds":"2-aminomuconate 6-semialdehyde + CO2 => 2-amino-3-carboxymuconate 6-semialdehyde + H(+)"}
{"X":19667,"RHEA_ID":26515,"compounds":"cyclohexan-1,2-dione + H2O => 6-oxohexanoate + H(+)"}
{"X":19668,"RHEA_ID":16561,"DIRECTION":"UN","MASTER_ID":16561,"ec":"4.2.1.129","compounds":"H2O + squalene = hopan-22-ol"}
{"X":19669,"RHEA_ID":16562,"DIRECTION":"LR","MASTER_ID":16561,"metacyc":"RXN-4961","compounds":"H2O + squalene => hopan-22-ol"}
{"X":19670,"RHEA_ID":16563,"compounds":"hopan-22-ol => H2O + squalene"}
{"X":19671,"RHEA_ID":26519,"compounds":"3-hydroxypropanoyl-CoA => acryloyl-CoA + H2O"}
{"X":19672,"RHEA_ID":16565,"DIRECTION":"UN","MASTER_ID":16565,"ec":"2.6.1.38","compounds":"2-oxoglutarate + L-histidine = 3-(imidazol-5-yl)pyruvate + L-glutamate"}
{"X":19673,"RHEA_ID":16566,"compounds":"2-oxoglutarate + L-histidine => 3-(imidazol-5-yl)pyruvate + L-glutamate"}
{"X":19674,"RHEA_ID":16567,"compounds":"3-(imidazol-5-yl)pyruvate + L-glutamate => 2-oxoglutarate + L-histidine"}
{"X":19675,"RHEA_ID":26523,"DIRECTION":"LR","MASTER_ID":26522,"metacyc":"RXN-8979","compounds":"(2S,3S)-2-methylcitrate => 2-methyl-trans-aconitate + H2O"}
{"X":19676,"RHEA_ID":16569,"DIRECTION":"UN","MASTER_ID":16569,"ec":"1.14.11.4","compounds":"2-oxoglutarate + L-lysyl-[procollagen] + O2 = (5R)-5-hydroxy-L-lysyl-[procollagen] + CO2 + succinate"}
{"X":19677,"RHEA_ID":16570,"DIRECTION":"LR","MASTER_ID":16569,"metacyc":"PROCOLLAGEN-LYSINE-5-DIOXYGENASE-RXN","compounds":"2-oxoglutarate + L-lysyl-[procollagen] + O2 => (5R)-5-hydroxy-L-lysyl-[procollagen] + CO2 + succinate"}
{"X":19678,"RHEA_ID":16571,"compounds":"(5R)-5-hydroxy-L-lysyl-[procollagen] + CO2 + succinate => 2-oxoglutarate + L-lysyl-[procollagen] + O2"}
{"X":19679,"RHEA_ID":26527,"compounds":"a (3R)-hydroxyacyl-CoA => a (2E)-enoyl-CoA + H2O"}
{"X":19680,"RHEA_ID":16573,"DIRECTION":"UN","MASTER_ID":16573,"ec":"2.6.1.52","compounds":"2-oxoglutarate + 4-(phosphooxy)-L-threonine = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate"}
{"X":19681,"RHEA_ID":16574,"compounds":"2-oxoglutarate + 4-(phosphooxy)-L-threonine => (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate"}
{"X":19682,"RHEA_ID":16575,"compounds":"(R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate => 2-oxoglutarate + 4-(phosphooxy)-L-threonine"}
{"X":19683,"RHEA_ID":26531,"compounds":"4-hydroxybutanoyl-CoA => (2E)-butenoyl-CoA + H2O"}
{"X":19684,"RHEA_ID":16577,"DIRECTION":"UN","MASTER_ID":16577,"ec":"2.7.7.53","compounds":"ADP + ATP + H(+) = P(1),P(4)-bis(5'-adenosyl) tetraphosphate + phosphate"}
{"X":19685,"RHEA_ID":16578,"compounds":"ADP + ATP + H(+) => P(1),P(4)-bis(5'-adenosyl) tetraphosphate + phosphate"}
{"X":19686,"RHEA_ID":16579,"compounds":"P(1),P(4)-bis(5'-adenosyl) tetraphosphate + phosphate => ADP + ATP + H(+)"}
{"X":19687,"RHEA_ID":26535,"DIRECTION":"LR","MASTER_ID":26534,"metacyc":"RXN-9086","compounds":"3-hydroxypropanoate + ATP + CoA => 3-hydroxypropanoyl-CoA + AMP + diphosphate"}
{"X":19688,"RHEA_ID":16581,"DIRECTION":"UN","MASTER_ID":16581,"ec":"1.11.1.5","compounds":"2 [Fe(II)cytochrome c] + 2 H(+) + H2O2 = 2 [Fe(III)cytochrome c] + 2 H2O"}
{"X":19689,"RHEA_ID":16582,"DIRECTION":"LR","MASTER_ID":16581,"metacyc":"CYTOCHROME-C-PEROXIDASE-RXN","compounds":"2 [Fe(II)cytochrome c] + 2 H(+) + H2O2 => 2 [Fe(III)cytochrome c] + 2 H2O"}
{"X":19690,"RHEA_ID":16583,"compounds":"2 [Fe(III)cytochrome c] + 2 H2O => 2 [Fe(II)cytochrome c] + 2 H(+) + H2O2"}
{"X":19691,"RHEA_ID":16585,"DIRECTION":"UN","MASTER_ID":16585,"ec":"2.8.1.8","compounds":"[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":19692,"RHEA_ID":16586,"DIRECTION":"LR","MASTER_ID":16585,"ecocyc":"RXN0-949","metacyc":"RXN0-949","compounds":"[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine => (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":19693,"RHEA_ID":16587,"compounds":"(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin] => [[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine"}
{"X":19694,"RHEA_ID":26543,"compounds":"(R)-piperazine-2-carboxamide + H2O => (R)-piperazine-2-carboxylate + NH4(+)"}
{"X":19695,"RHEA_ID":16589,"DIRECTION":"UN","MASTER_ID":16589,"ec":"1.1.99.13","compounds":"A + sucrose = 3-dehydro-alpha-D-glucosyl beta-D-fructofuranoside + AH2"}
{"X":19696,"RHEA_ID":16590,"DIRECTION":"LR","MASTER_ID":16589,"metacyc":"GLUCOSIDE-3-DEHYDROGENASE-RXN","compounds":"A + sucrose => 3-dehydro-alpha-D-glucosyl beta-D-fructofuranoside + AH2"}
{"X":19697,"RHEA_ID":16591,"compounds":"3-dehydro-alpha-D-glucosyl beta-D-fructofuranoside + AH2 => A + sucrose"}
{"X":19698,"RHEA_ID":26547,"compounds":"beta-alaninamide + H2O => beta-alanine + NH4(+)"}
{"X":19699,"RHEA_ID":16593,"DIRECTION":"UN","MASTER_ID":16593,"ec":"2.1.1.88","compounds":"3,3',4',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine = 3,3',4',5,7-pentahydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine"}
{"X":19700,"RHEA_ID":16594,"DIRECTION":"LR","MASTER_ID":16593,"metacyc":"2.1.1.88-RXN","compounds":"3,3',4',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine => 3,3',4',5,7-pentahydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine"}
{"X":19701,"RHEA_ID":16595,"compounds":"3,3',4',5,7-pentahydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine => 3,3',4',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine"}
{"X":19702,"RHEA_ID":26551,"compounds":"(S)-piperazine-2-carboxamide + H2O => (S)-piperazine-2-carboxylate + NH4(+)"}
{"X":19703,"RHEA_ID":16597,"compounds":"ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate"}
{"X":19704,"RHEA_ID":16598,"DIRECTION":"LR","MASTER_ID":16597,"ecocyc":"RXN-14325","metacyc":"RXN-14325","compounds":"ATP + NH4(+) + UTP => ADP + CTP + 2 H(+) + phosphate"}
{"X":19705,"RHEA_ID":16599,"compounds":"ADP + CTP + 2 H(+) + phosphate => ATP + NH4(+) + UTP"}
{"X":19706,"RHEA_ID":26555,"compounds":"angiotensin II + H2O => angiotensin-(1-7) + L-phenylalanine"}
{"X":19707,"RHEA_ID":16601,"DIRECTION":"UN","MASTER_ID":16601,"ec":"4.3.1.1","compounds":"L-aspartate = fumarate + NH4(+)"}
{"X":19708,"RHEA_ID":16602,"compounds":"L-aspartate => fumarate + NH4(+)"}
{"X":19709,"RHEA_ID":16603,"compounds":"fumarate + NH4(+) => L-aspartate"}
{"X":19710,"RHEA_ID":26559,"compounds":"(3S)-hydroxybutanoyl-CoA => (2E)-butenoyl-CoA + H2O"}
{"X":19711,"RHEA_ID":16605,"DIRECTION":"UN","MASTER_ID":16605,"ec":"2.3.3.2","metacyc":"DECYLCITRATE-SYNTHASE-RXN","compounds":"dodecanoyl-CoA + H2O + oxaloacetate = (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA + H(+)"}
{"X":19712,"RHEA_ID":16606,"compounds":"dodecanoyl-CoA + H2O + oxaloacetate => (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA + H(+)"}
{"X":19713,"RHEA_ID":16607,"compounds":"(2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA + H(+) => dodecanoyl-CoA + H2O + oxaloacetate"}
{"X":19714,"RHEA_ID":26563,"DIRECTION":"LR","MASTER_ID":26562,"ecocyc":"NAPHTHOATE-SYN-RXN","metacyc":"NAPHTHOATE-SYN-RXN","compounds":"2-succinylbenzoyl-CoA + H(+) => 1,4-dihydroxy-2-naphthoyl-CoA + H2O"}
{"X":19715,"RHEA_ID":16609,"DIRECTION":"UN","MASTER_ID":16609,"ec":"2.4.2.7","compounds":"AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine"}
{"X":19716,"RHEA_ID":16610,"compounds":"AMP + diphosphate => 5-phospho-alpha-D-ribose 1-diphosphate + adenine"}
{"X":19717,"RHEA_ID":16611,"DIRECTION":"RL","MASTER_ID":16609,"ecocyc":"ADENPRIBOSYLTRAN-RXN","reactome":"R-HSA-74213.2","compounds":"5-phospho-alpha-D-ribose 1-diphosphate + adenine => AMP + diphosphate"}
{"X":19718,"RHEA_ID":27271,"compounds":"CoA + hexadecanal + NADP(+) => H(+) + hexadecanoyl-CoA + NADPH"}
{"X":19719,"RHEA_ID":16613,"DIRECTION":"UN","MASTER_ID":16613,"ec":"2.3.1.5","compounds":"acetyl-CoA + an arylamine = an N-acetylarylamine + CoA"}
{"X":19720,"RHEA_ID":16614,"DIRECTION":"LR","MASTER_ID":16613,"ecocyc":"ARYLAMINE-N-ACETYLTRANSFERASE-RXN","metacyc":"ARYLAMINE-N-ACETYLTRANSFERASE-RXN","compounds":"acetyl-CoA + an arylamine => an N-acetylarylamine + CoA"}
{"X":19721,"RHEA_ID":16615,"compounds":"an N-acetylarylamine + CoA => acetyl-CoA + an arylamine"}
{"X":19722,"RHEA_ID":16616,"compounds":"acetyl-CoA + an arylamine <=> an N-acetylarylamine + CoA"}
{"X":19723,"RHEA_ID":16617,"DIRECTION":"UN","MASTER_ID":16617,"ec":"2.4.1.31","compounds":"beta-D-glucosyl-(1->3)-D-glucose + phosphate = alpha-D-glucose 1-phosphate + D-glucose"}
{"X":19724,"RHEA_ID":16618,"DIRECTION":"LR","MASTER_ID":16617,"metacyc":"LAMINARIBIOSE-PHOSPHORYLASE-RXN","compounds":"beta-D-glucosyl-(1->3)-D-glucose + phosphate => alpha-D-glucose 1-phosphate + D-glucose"}
{"X":19725,"RHEA_ID":16619,"compounds":"alpha-D-glucose 1-phosphate + D-glucose => beta-D-glucosyl-(1->3)-D-glucose + phosphate"}
{"X":19726,"RHEA_ID":27279,"compounds":"2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) => 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADPH"}
{"X":19727,"RHEA_ID":16621,"DIRECTION":"UN","MASTER_ID":16621,"ec":"1.5.3.12","compounds":"dihydrosanguinarine + H(+) + O2 = H2O2 + sanguinarine"}
{"X":19728,"RHEA_ID":16622,"DIRECTION":"LR","MASTER_ID":16621,"metacyc":"1.5.3.12-RXN","compounds":"dihydrosanguinarine + H(+) + O2 => H2O2 + sanguinarine"}
{"X":19729,"RHEA_ID":16623,"compounds":"H2O2 + sanguinarine => dihydrosanguinarine + H(+) + O2"}
{"X":19730,"RHEA_ID":16625,"DIRECTION":"UN","MASTER_ID":16625,"ec":"2.3.1.10","metacyc":"HYDROGEN-SULFIDE-S-ACETYLTRANSFERASE-RXN","compounds":"acetyl-CoA + hydrogen sulfide = CoA + thioacetate"}
{"X":19731,"RHEA_ID":16626,"compounds":"acetyl-CoA + hydrogen sulfide => CoA + thioacetate"}
{"X":19732,"RHEA_ID":16627,"compounds":"CoA + thioacetate => acetyl-CoA + hydrogen sulfide"}
{"X":19733,"RHEA_ID":27287,"compounds":"(S)-acetoin + NAD(+) => diacetyl + H(+) + NADH"}
{"X":19734,"RHEA_ID":16629,"DIRECTION":"UN","MASTER_ID":16629,"ec":"4.1.3.24","compounds":"(S)-malyl-CoA = acetyl-CoA + glyoxylate"}
{"X":19735,"RHEA_ID":16630,"compounds":"(S)-malyl-CoA => acetyl-CoA + glyoxylate"}
{"X":19736,"RHEA_ID":16631,"compounds":"acetyl-CoA + glyoxylate => (S)-malyl-CoA"}
{"X":19737,"RHEA_ID":27291,"DIRECTION":"LR","MASTER_ID":27290,"ecocyc":"RXN0-3281","metacyc":"RXN0-3281","compounds":"A + formate + H(+) => AH2 + CO2"}
{"X":19738,"RHEA_ID":16633,"DIRECTION":"UN","MASTER_ID":16633,"ec":"2.4.2.29","compounds":"guanosine(34) in tRNA + queuine = guanine + queuosine(34) in tRNA"}
{"X":19739,"RHEA_ID":16634,"DIRECTION":"LR","MASTER_ID":16633,"metacyc":"QUEUOSINE-TRNA-RIBOSYLTRANSFERASE-RXN","compounds":"guanosine(34) in tRNA + queuine => guanine + queuosine(34) in tRNA"}
{"X":19740,"RHEA_ID":16635,"compounds":"guanine + queuosine(34) in tRNA => guanosine(34) in tRNA + queuine"}
{"X":19741,"RHEA_ID":27295,"compounds":"D-glucose 6-phosphate + H(+) + oxidized coenzyme F420-(gamma-Glu)(n) => 6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420-(gamma-Glu)(n)"}
{"X":19742,"RHEA_ID":16637,"DIRECTION":"UN","MASTER_ID":16637,"ec":"2.4.1.16","compounds":"[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + H(+) + UDP"}
{"X":19743,"RHEA_ID":16638,"DIRECTION":"LR","MASTER_ID":16637,"metacyc":"CHITIN-SYNTHASE-RXN","compounds":"[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine => [(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + H(+) + UDP"}
{"X":19744,"RHEA_ID":16639,"compounds":"[(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + H(+) + UDP => [(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":19745,"RHEA_ID":27299,"compounds":"2-formylbenzoate + H2O + NAD(+) => 2 H(+) + NADH + phthalate"}
{"X":19746,"RHEA_ID":16641,"DIRECTION":"UN","MASTER_ID":16641,"ec":"3.1.1.67","compounds":"a long-chain fatty acyl ethyl ester + H2O = a long-chain fatty acid + ethanol + H(+)"}
{"X":19747,"RHEA_ID":16642,"DIRECTION":"LR","MASTER_ID":16641,"metacyc":"FATTY-ACYL-ETHYL-ESTER-SYNTHASE-RXN","compounds":"a long-chain fatty acyl ethyl ester + H2O => a long-chain fatty acid + ethanol + H(+)"}
{"X":19748,"RHEA_ID":16643,"compounds":"a long-chain fatty acid + ethanol + H(+) => a long-chain fatty acyl ethyl ester + H2O"}
{"X":19749,"RHEA_ID":16645,"DIRECTION":"UN","MASTER_ID":16645,"ec":"3.1.2.2","compounds":"H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate"}
{"X":19750,"RHEA_ID":16646,"DIRECTION":"LR","MASTER_ID":16645,"metacyc":"PALMITOYL-COA-HYDROLASE-RXN","reactome":"R-HSA-5690046.1","compounds":"H2O + hexadecanoyl-CoA => CoA + H(+) + hexadecanoate"}
{"X":19751,"RHEA_ID":16647,"compounds":"CoA + H(+) + hexadecanoate => H2O + hexadecanoyl-CoA"}
{"X":19752,"RHEA_ID":16649,"DIRECTION":"UN","MASTER_ID":16649,"ec":"1.14.14.102","compounds":"(S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase] = (S)-3'-hydroxy-N-methylcoclaurine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":19753,"RHEA_ID":16650,"DIRECTION":"LR","MASTER_ID":16649,"metacyc":"1.14.13.71-RXN","compounds":"(S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase] => (S)-3'-hydroxy-N-methylcoclaurine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":19754,"RHEA_ID":16651,"compounds":"(S)-3'-hydroxy-N-methylcoclaurine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":19755,"RHEA_ID":27311,"DIRECTION":"LR","MASTER_ID":27310,"metacyc":"RXN-8612","compounds":"naphthalene-1,2-diol + O2 => 2-hydroxychromene-2-carboxylate + H(+)"}
{"X":19756,"RHEA_ID":16653,"DIRECTION":"UN","MASTER_ID":16653,"ec":"1.1.1.215","compounds":"D-gluconate + NADP(+) = 2-dehydro-D-gluconate + H(+) + NADPH"}
{"X":19757,"RHEA_ID":16654,"compounds":"D-gluconate + NADP(+) => 2-dehydro-D-gluconate + H(+) + NADPH"}
{"X":19758,"RHEA_ID":16655,"compounds":"2-dehydro-D-gluconate + H(+) + NADPH => D-gluconate + NADP(+)"}
{"X":19759,"RHEA_ID":27315,"DIRECTION":"LR","MASTER_ID":27314,"metacyc":"RXN-10845","compounds":"dichlorochromopyrrolate + 6 H(+) + 4 NADH + 4 O2 => 2 CO2 + dichloroarcyriaflavin A + 6 H2O + 4 NAD(+)"}
{"X":19760,"RHEA_ID":16657,"DIRECTION":"UN","MASTER_ID":16657,"ec":"3.2.2.2","compounds":"H2O + inosine = D-ribose + hypoxanthine"}
{"X":19761,"RHEA_ID":16658,"DIRECTION":"LR","MASTER_ID":16657,"ecocyc":"INOSINE-NUCLEOSIDASE-RXN","metacyc":"INOSINE-NUCLEOSIDASE-RXN","compounds":"H2O + inosine => D-ribose + hypoxanthine"}
{"X":19762,"RHEA_ID":16659,"compounds":"D-ribose + hypoxanthine => H2O + inosine"}
{"X":19763,"RHEA_ID":27319,"DIRECTION":"LR","MASTER_ID":27318,"reactome":"R-HSA-109527.1","compounds":"uracil(in) => uracil(out)"}
{"X":19764,"RHEA_ID":16661,"DIRECTION":"UN","MASTER_ID":16661,"ec":"2.5.1.63","compounds":"fluoride + S-adenosyl-L-methionine = 5'-deoxy-5'-fluoroadenosine + L-methionine"}
{"X":19765,"RHEA_ID":16662,"DIRECTION":"LR","MASTER_ID":16661,"metacyc":"2.5.1.63-RXN","compounds":"fluoride + S-adenosyl-L-methionine => 5'-deoxy-5'-fluoroadenosine + L-methionine"}
{"X":19766,"RHEA_ID":16663,"compounds":"5'-deoxy-5'-fluoroadenosine + L-methionine => fluoride + S-adenosyl-L-methionine"}
{"X":19767,"RHEA_ID":27323,"compounds":"6-deoxotyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-epi-6-deoxocathasterone + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":19768,"RHEA_ID":16665,"DIRECTION":"UN","MASTER_ID":16665,"ec":"3.3.2.7","compounds":"(5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O = (5Z,9E,14Z)-(8xi,11xi,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate"}
{"X":19769,"RHEA_ID":16666,"DIRECTION":"LR","MASTER_ID":16665,"metacyc":"HEPOXILIN-EPOXIDE-HYDROLASE-RXN","compounds":"(5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O => (5Z,9E,14Z)-(8xi,11xi,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate"}
{"X":19770,"RHEA_ID":16667,"compounds":"(5Z,9E,14Z)-(8xi,11xi,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate => (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O"}
{"X":19771,"RHEA_ID":27327,"compounds":"3-dehydro-6-deoxoteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (22S,24R)-22-hydroxy-5alpha-ergostan-3-one + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":19772,"RHEA_ID":16669,"DIRECTION":"UN","MASTER_ID":16669,"ec":"1.17.1.4","compounds":"H2O + NAD(+) + xanthine = H(+) + NADH + urate"}
{"X":19773,"RHEA_ID":16670,"DIRECTION":"LR","MASTER_ID":16669,"ecocyc":"RXN0-901","macie":"M0139","compounds":"H2O + NAD(+) + xanthine => H(+) + NADH + urate"}
{"X":19774,"RHEA_ID":16671,"compounds":"H(+) + NADH + urate => H2O + NAD(+) + xanthine"}
{"X":19775,"RHEA_ID":27331,"compounds":"5-hydroxyisourate + H2O + NAD(+) => H(+) + NADH + O2 + urate"}
{"X":19776,"RHEA_ID":16673,"DIRECTION":"UN","MASTER_ID":16673,"ec":"3.11.1.3","compounds":"3-phosphonopyruvate + H2O = H(+) + phosphate + pyruvate"}
{"X":19777,"RHEA_ID":16674,"compounds":"3-phosphonopyruvate + H2O => H(+) + phosphate + pyruvate"}
{"X":19778,"RHEA_ID":16675,"compounds":"H(+) + phosphate + pyruvate => 3-phosphonopyruvate + H2O"}
{"X":19779,"RHEA_ID":16677,"DIRECTION":"UN","MASTER_ID":16677,"ec":"1.2.1.69","compounds":"fluoroacetaldehyde + H2O + NAD(+) = fluoroacetate + 2 H(+) + NADH"}
{"X":19780,"RHEA_ID":16678,"DIRECTION":"LR","MASTER_ID":16677,"metacyc":"RXN-11746","compounds":"fluoroacetaldehyde + H2O + NAD(+) => fluoroacetate + 2 H(+) + NADH"}
{"X":19781,"RHEA_ID":16679,"compounds":"fluoroacetate + 2 H(+) + NADH => fluoroacetaldehyde + H2O + NAD(+)"}
{"X":19782,"RHEA_ID":16681,"compounds":"4-hydroxyphenylacetate + H(+) + NADH + O2 = 3,4-dihydroxyphenylacetate + H2O + NAD(+)"}
{"X":19783,"RHEA_ID":16682,"compounds":"4-hydroxyphenylacetate + H(+) + NADH + O2 => 3,4-dihydroxyphenylacetate + H2O + NAD(+)"}
{"X":19784,"RHEA_ID":16683,"compounds":"3,4-dihydroxyphenylacetate + H2O + NAD(+) => 4-hydroxyphenylacetate + H(+) + NADH + O2"}
{"X":19785,"RHEA_ID":27343,"compounds":"A + H(+) + H2O + hydroxylamine => AH2 + NH4(+) + O2"}
{"X":19786,"RHEA_ID":16685,"DIRECTION":"UN","MASTER_ID":16685,"ec":"2.3.1.123","compounds":"di-trans,poly-cis-dolichol + hexadecanoyl-CoA = CoA + dolichyl hexadecanoate"}
{"X":19787,"RHEA_ID":16686,"DIRECTION":"LR","MASTER_ID":16685,"metacyc":"DOLICHOL-O-ACYLTRANSFERASE-RXN","compounds":"di-trans,poly-cis-dolichol + hexadecanoyl-CoA => CoA + dolichyl hexadecanoate"}
{"X":19788,"RHEA_ID":16687,"compounds":"CoA + dolichyl hexadecanoate => di-trans,poly-cis-dolichol + hexadecanoyl-CoA"}
{"X":19789,"RHEA_ID":16689,"DIRECTION":"UN","MASTER_ID":16689,"ec":"3.1.3.9","compounds":"D-glucose 6-phosphate + H2O = D-glucose + phosphate"}
{"X":19790,"RHEA_ID":16689,"DIRECTION":"UN","MASTER_ID":16689,"ec":"3.1.3.58","compounds":"D-glucose 6-phosphate + H2O = D-glucose + phosphate"}
{"X":19791,"RHEA_ID":16690,"DIRECTION":"LR","MASTER_ID":16689,"ecocyc":"RXN66-526","metacyc":"RXN66-526","compounds":"D-glucose 6-phosphate + H2O => D-glucose + phosphate"}
{"X":19792,"RHEA_ID":16691,"compounds":"D-glucose + phosphate => D-glucose 6-phosphate + H2O"}
{"X":19793,"RHEA_ID":27352,"compounds":"arsenate + mycothiol <=> arseno-mycothiol + H2O"}
{"X":19794,"RHEA_ID":16693,"DIRECTION":"UN","MASTER_ID":16693,"ec":"5.5.1.10","metacyc":"ALPHA-PINENE-OXIDE-DECYCLASE-RXN","compounds":"alpha-pinene oxide = (Z)-2-methyl-5-isopropylhexa-2,5-dienal"}
{"X":19795,"RHEA_ID":16694,"compounds":"alpha-pinene oxide => (Z)-2-methyl-5-isopropylhexa-2,5-dienal"}
{"X":19796,"RHEA_ID":16695,"compounds":"(Z)-2-methyl-5-isopropylhexa-2,5-dienal => alpha-pinene oxide"}
{"X":19797,"RHEA_ID":37198,"compounds":"octadecanoyl-CoA + sn-glycerol 3-phosphate <=> 1-octadecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":19798,"RHEA_ID":16697,"DIRECTION":"UN","MASTER_ID":16697,"ec":"1.3.99.18","metacyc":"1.3.99.18-RXN","compounds":"A + H2O + quinaldate = AH2 + kynurenate"}
{"X":19799,"RHEA_ID":16698,"compounds":"A + H2O + quinaldate => AH2 + kynurenate"}
{"X":19800,"RHEA_ID":16699,"compounds":"AH2 + kynurenate => A + H2O + quinaldate"}
{"X":19801,"RHEA_ID":37202,"compounds":"(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphate <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":19802,"RHEA_ID":16701,"DIRECTION":"UN","MASTER_ID":16701,"ec":"1.1.1.148","metacyc":"ESTRADIOL-17-ALPHA-DEHYDROGENASE-RXN","compounds":"17alpha-estradiol + NAD(+) = estrone + H(+) + NADH"}
{"X":19803,"RHEA_ID":16702,"compounds":"17alpha-estradiol + NAD(+) => estrone + H(+) + NADH"}
{"X":19804,"RHEA_ID":16703,"compounds":"estrone + H(+) + NADH => 17alpha-estradiol + NAD(+)"}
{"X":19805,"RHEA_ID":27364,"compounds":"chloride + S-adenosyl-L-methionine <=> chloromethane + S-adenosyl-L-homocysteine"}
{"X":19806,"RHEA_ID":16705,"DIRECTION":"UN","MASTER_ID":16705,"ec":"1.1.1.148","metacyc":"ESTRADIOL-17-ALPHA-DEHYDROGENASE-RXN","compounds":"17alpha-estradiol + NADP(+) = estrone + H(+) + NADPH"}
{"X":19807,"RHEA_ID":16706,"compounds":"17alpha-estradiol + NADP(+) => estrone + H(+) + NADPH"}
{"X":19808,"RHEA_ID":16707,"compounds":"estrone + H(+) + NADPH => 17alpha-estradiol + NADP(+)"}
{"X":19809,"RHEA_ID":27368,"compounds":"bromide + S-adenosyl-L-methionine <=> bromomethane + S-adenosyl-L-homocysteine"}
{"X":19810,"RHEA_ID":16709,"DIRECTION":"UN","MASTER_ID":16709,"ec":"1.14.16.4","compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 5-hydroxy-L-tryptophan"}
{"X":19811,"RHEA_ID":16710,"DIRECTION":"LR","MASTER_ID":16709,"metacyc":"TRYPTOPHAN-5-MONOOXYGENASE-RXN","compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 => (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 5-hydroxy-L-tryptophan"}
{"X":19812,"RHEA_ID":16711,"compounds":"(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 5-hydroxy-L-tryptophan => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2"}
{"X":19813,"RHEA_ID":37214,"compounds":"2',3'-cyclic GMP + H2O <=> guanosine 2'-monophosphate + H(+)"}
{"X":19814,"RHEA_ID":16713,"DIRECTION":"UN","MASTER_ID":16713,"ec":"3.1.2.13","compounds":"H2O + S-succinylglutathione = glutathione + H(+) + succinate"}
{"X":19815,"RHEA_ID":16714,"DIRECTION":"LR","MASTER_ID":16713,"metacyc":"S-SUCCINYLGLUTATHIONE-HYDROLASE-RXN","compounds":"H2O + S-succinylglutathione => glutathione + H(+) + succinate"}
{"X":19816,"RHEA_ID":16715,"compounds":"glutathione + H(+) + succinate => H2O + S-succinylglutathione"}
{"X":19817,"RHEA_ID":27376,"compounds":"5-amino-6-(D-ribitylamino)uracil + L-tyrosine + 2 S-adenosyl-L-methionine <=> 2-iminoacetate + 2 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + 2 H(+) + 2 L-methionine + NH4(+)"}
{"X":19818,"RHEA_ID":16717,"compounds":"deoxycholate + FAD + H(+) + H2O = cholate + FADH2"}
{"X":19819,"RHEA_ID":16718,"compounds":"deoxycholate + FAD + H(+) + H2O => cholate + FADH2"}
{"X":19820,"RHEA_ID":16719,"compounds":"cholate + FADH2 => deoxycholate + FAD + H(+) + H2O"}
{"X":19821,"RHEA_ID":27380,"compounds":"(R)-glycerate + ATP <=> (2R)-2-phosphoglycerate + ADP + H(+)"}
{"X":19822,"RHEA_ID":16721,"DIRECTION":"UN","MASTER_ID":16721,"ec":"1.5.98.1","compounds":"5,10-methylenetetrahydromethanopterin + 2 H(+) + oxidized coenzyme F420-(gamma-Glu)(n) = 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420-(gamma-Glu)(n)"}
{"X":19823,"RHEA_ID":16722,"compounds":"5,10-methylenetetrahydromethanopterin + 2 H(+) + oxidized coenzyme F420-(gamma-Glu)(n) => 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420-(gamma-Glu)(n)"}
{"X":19824,"RHEA_ID":16723,"compounds":"5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420-(gamma-Glu)(n) => 5,10-methylenetetrahydromethanopterin + 2 H(+) + oxidized coenzyme F420-(gamma-Glu)(n)"}
{"X":19825,"RHEA_ID":37230,"compounds":"(E,E)-sorbate + H(+) <=> (E)-1,3-pentadiene + CO2"}
{"X":19826,"RHEA_ID":16725,"compounds":"a phosphatidylglycerol phosphate + H2O = a phosphatidylglycerol + phosphate"}
{"X":19827,"RHEA_ID":16726,"compounds":"a phosphatidylglycerol phosphate + H2O => a phosphatidylglycerol + phosphate"}
{"X":19828,"RHEA_ID":16727,"compounds":"a phosphatidylglycerol + phosphate => a phosphatidylglycerol phosphate + H2O"}
{"X":19829,"RHEA_ID":16728,"compounds":"a phosphatidylglycerol phosphate + H2O <=> a phosphatidylglycerol + phosphate"}
{"X":19830,"RHEA_ID":16729,"DIRECTION":"UN","MASTER_ID":16729,"ec":"1.3.1.20","compounds":"NADP(+) + trans-1,2-dihydrobenzene-1,2-diol = catechol + H(+) + NADPH"}
{"X":19831,"RHEA_ID":16730,"compounds":"NADP(+) + trans-1,2-dihydrobenzene-1,2-diol => catechol + H(+) + NADPH"}
{"X":19832,"RHEA_ID":16731,"compounds":"catechol + H(+) + NADPH => NADP(+) + trans-1,2-dihydrobenzene-1,2-diol"}
{"X":19833,"RHEA_ID":37242,"compounds":"2',3'-cyclic UMP + H2O <=> H(+) + uridine 2'-phosphate"}
{"X":19834,"RHEA_ID":16733,"DIRECTION":"UN","MASTER_ID":16733,"ec":"4.1.1.58","metacyc":"ORSELLINATE-DECARBOXYLASE-RXN","compounds":"H(+) + orsellinate = CO2 + orcinol"}
{"X":19835,"RHEA_ID":16734,"compounds":"H(+) + orsellinate => CO2 + orcinol"}
{"X":19836,"RHEA_ID":16735,"compounds":"CO2 + orcinol => H(+) + orsellinate"}
{"X":19837,"RHEA_ID":37246,"compounds":"(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + CO2 + CoA"}
{"X":19838,"RHEA_ID":16737,"DIRECTION":"UN","MASTER_ID":16737,"ec":"1.14.12.11","compounds":"H(+) + NADH + O2 + toluene = (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+)"}
{"X":19839,"RHEA_ID":16738,"DIRECTION":"LR","MASTER_ID":16737,"metacyc":"TOLUENE-DIOXYGENASE-RXN","compounds":"H(+) + NADH + O2 + toluene => (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+)"}
{"X":19840,"RHEA_ID":16739,"compounds":"(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+) => H(+) + NADH + O2 + toluene"}
{"X":19841,"RHEA_ID":37250,"compounds":"H2O + thymidine 3'-monophosphate <=> phosphate + thymidine"}
{"X":19842,"RHEA_ID":16741,"compounds":"a 2-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA"}
{"X":19843,"RHEA_ID":16742,"compounds":"a 2-acylglycerol + an acyl-CoA => a 1,2-diacylglycerol + CoA"}
{"X":19844,"RHEA_ID":16743,"compounds":"a 1,2-diacylglycerol + CoA => a 2-acylglycerol + an acyl-CoA"}
{"X":19845,"RHEA_ID":16744,"compounds":"a 2-acylglycerol + an acyl-CoA <=> a 1,2-diacylglycerol + CoA"}
{"X":19846,"RHEA_ID":16745,"DIRECTION":"UN","MASTER_ID":16745,"ec":"1.14.99.20","compounds":"AH2 + O2 + phylloquinone = 2,3-epoxyphylloquinone + A + H2O"}
{"X":19847,"RHEA_ID":16746,"DIRECTION":"LR","MASTER_ID":16745,"metacyc":"1.14.99.20-RXN","compounds":"AH2 + O2 + phylloquinone => 2,3-epoxyphylloquinone + A + H2O"}
{"X":19848,"RHEA_ID":16747,"compounds":"2,3-epoxyphylloquinone + A + H2O => AH2 + O2 + phylloquinone"}
{"X":19849,"RHEA_ID":27408,"compounds":"a ubiquinone + H2O + pyruvate <=> a ubiquinol + acetate + CO2"}
{"X":19850,"RHEA_ID":16749,"DIRECTION":"UN","MASTER_ID":16749,"ec":"3.11.1.2","compounds":"H2O + phosphonoacetate = acetate + H(+) + phosphate"}
{"X":19851,"RHEA_ID":16750,"compounds":"H2O + phosphonoacetate => acetate + H(+) + phosphate"}
{"X":19852,"RHEA_ID":16751,"compounds":"acetate + H(+) + phosphate => H2O + phosphonoacetate"}
{"X":19853,"RHEA_ID":16753,"compounds":"Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADPH + O2 = 3,8-divinyl protochlorophyllide a + 2 H2O + NADP(+)"}
{"X":19854,"RHEA_ID":16754,"DIRECTION":"LR","MASTER_ID":16753,"metacyc":"RXN-5284","compounds":"Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADPH + O2 => 3,8-divinyl protochlorophyllide a + 2 H2O + NADP(+)"}
{"X":19855,"RHEA_ID":16755,"compounds":"3,8-divinyl protochlorophyllide a + 2 H2O + NADP(+) => Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADPH + O2"}
{"X":19856,"RHEA_ID":37266,"compounds":"ATP + H2O + L-alanyl-L-aspartate(out) <=> ADP + H(+) + L-alanyl-L-aspartate(in) + phosphate"}
{"X":19857,"RHEA_ID":16757,"DIRECTION":"UN","MASTER_ID":16757,"ec":"1.8.1.12","compounds":"NADP(+) + trypanothione = H(+) + NADPH + trypanothione disulfide"}
{"X":19858,"RHEA_ID":16758,"compounds":"NADP(+) + trypanothione => H(+) + NADPH + trypanothione disulfide"}
{"X":19859,"RHEA_ID":16759,"compounds":"H(+) + NADPH + trypanothione disulfide => NADP(+) + trypanothione"}
{"X":19860,"RHEA_ID":37270,"compounds":"H2O + L-alanyl-L-aspartate <=> L-alanine + L-aspartate"}
{"X":19861,"RHEA_ID":16761,"compounds":"chlorohydroquinone + O2 = 5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H(+)"}
{"X":19862,"RHEA_ID":16762,"DIRECTION":"LR","MASTER_ID":16761,"metacyc":"LINE-RXN","compounds":"chlorohydroquinone + O2 => 5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H(+)"}
{"X":19863,"RHEA_ID":16763,"compounds":"5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H(+) => chlorohydroquinone + O2"}
{"X":19864,"RHEA_ID":16764,"compounds":"chlorohydroquinone + O2 <=> 5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H(+)"}
{"X":19865,"RHEA_ID":16765,"DIRECTION":"UN","MASTER_ID":16765,"ec":"1.1.1.138","compounds":"D-mannitol + NADP(+) = D-fructose + H(+) + NADPH"}
{"X":19866,"RHEA_ID":16766,"compounds":"D-mannitol + NADP(+) => D-fructose + H(+) + NADPH"}
{"X":19867,"RHEA_ID":16767,"compounds":"D-fructose + H(+) + NADPH => D-mannitol + NADP(+)"}
{"X":19868,"RHEA_ID":27428,"compounds":"(2E,6E)-farnesyl diphosphate <=> (E)-beta-farnesene + diphosphate"}
{"X":19869,"RHEA_ID":16769,"DIRECTION":"UN","MASTER_ID":16769,"ec":"2.7.1.106","compounds":"(2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 1-phosphate = (2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+)"}
{"X":19870,"RHEA_ID":16770,"compounds":"(2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 1-phosphate => (2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+)"}
{"X":19871,"RHEA_ID":16771,"compounds":"(2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+) => (2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 1-phosphate"}
{"X":19872,"RHEA_ID":16773,"DIRECTION":"UN","MASTER_ID":16773,"ec":"2.4.1.62","compounds":"ganglioside GM2 (d18:1(4E)) + UDP-alpha-D-galactose = ganglioside GM1 (d18:1(4E)) + H(+) + UDP"}
{"X":19873,"RHEA_ID":16774,"DIRECTION":"LR","MASTER_ID":16773,"metacyc":"GANGLIOSIDE-GALACTOSYLTRANSFERASE-RXN","compounds":"ganglioside GM2 (d18:1(4E)) + UDP-alpha-D-galactose => ganglioside GM1 (d18:1(4E)) + H(+) + UDP"}
{"X":19874,"RHEA_ID":16775,"compounds":"ganglioside GM1 (d18:1(4E)) + H(+) + UDP => ganglioside GM2 (d18:1(4E)) + UDP-alpha-D-galactose"}
{"X":19875,"RHEA_ID":37286,"compounds":"H2O + L-alanyl-L-histidine <=> L-alanine + L-histidine"}
{"X":19876,"RHEA_ID":16777,"DIRECTION":"UN","MASTER_ID":16777,"ec":"7.2.2.6","compounds":"ATP + H2O + K(+)(out) = ADP + H(+) + K(+)(in) + phosphate"}
{"X":19877,"RHEA_ID":16778,"DIRECTION":"LR","MASTER_ID":16777,"ecocyc":"TRANS-RXN-2","metacyc":"3.6.3.12-RXN","compounds":"ATP + H2O + K(+)(out) => ADP + H(+) + K(+)(in) + phosphate"}
{"X":19878,"RHEA_ID":16779,"compounds":"ADP + H(+) + K(+)(in) + phosphate => ATP + H2O + K(+)(out)"}
{"X":19879,"RHEA_ID":16780,"compounds":"ATP + H2O + K(+)(out) <=> ADP + H(+) + K(+)(in) + phosphate"}
{"X":19880,"RHEA_ID":16781,"DIRECTION":"UN","MASTER_ID":16781,"ec":"3.1.2.18","compounds":"an acyl-CoA + H2O = a fatty acid + CoA + H(+)"}
{"X":19881,"RHEA_ID":16781,"DIRECTION":"UN","MASTER_ID":16781,"ec":"3.1.2.19","compounds":"an acyl-CoA + H2O = a fatty acid + CoA + H(+)"}
{"X":19882,"RHEA_ID":16781,"DIRECTION":"UN","MASTER_ID":16781,"ec":"3.1.2.20","compounds":"an acyl-CoA + H2O = a fatty acid + CoA + H(+)"}
{"X":19883,"RHEA_ID":16782,"DIRECTION":"LR","MASTER_ID":16781,"ecocyc":"ACYL-COA-HYDROLASE-RXN","metacyc":"ACYL-COA-HYDROLASE-RXN","compounds":"an acyl-CoA + H2O => a fatty acid + CoA + H(+)"}
{"X":19884,"RHEA_ID":16783,"compounds":"a fatty acid + CoA + H(+) => an acyl-CoA + H2O"}
{"X":19885,"RHEA_ID":16785,"DIRECTION":"UN","MASTER_ID":16785,"ec":"2.1.1.55","compounds":"an adenosine in tRNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":19886,"RHEA_ID":16786,"DIRECTION":"LR","MASTER_ID":16785,"metacyc":"TRNA-ADENINE-N6--METHYLTRANSFERASE-RXN","compounds":"an adenosine in tRNA + S-adenosyl-L-methionine => an N(6)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":19887,"RHEA_ID":16787,"compounds":"an N(6)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine => an adenosine in tRNA + S-adenosyl-L-methionine"}
{"X":19888,"RHEA_ID":27451,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + phosphate => a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O"}
{"X":19889,"RHEA_ID":16789,"DIRECTION":"UN","MASTER_ID":16789,"ec":"1.1.3.15","compounds":"a (2S)-2-hydroxycarboxylate + O2 = a 2-oxocarboxylate + H2O2"}
{"X":19890,"RHEA_ID":16790,"DIRECTION":"LR","MASTER_ID":16789,"metacyc":"S-2-HYDROXY-ACID-OXIDASE-RXN","compounds":"a (2S)-2-hydroxycarboxylate + O2 => a 2-oxocarboxylate + H2O2"}
{"X":19891,"RHEA_ID":16791,"compounds":"a 2-oxocarboxylate + H2O2 => a (2S)-2-hydroxycarboxylate + O2"}
{"X":19892,"RHEA_ID":16793,"DIRECTION":"UN","MASTER_ID":16793,"ec":"4.1.1.36","compounds":"H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = CO2 + D-pantetheine 4'-phosphate"}
{"X":19893,"RHEA_ID":16794,"DIRECTION":"LR","MASTER_ID":16793,"ecocyc":"P-PANTOCYSDECARB-RXN","metacyc":"P-PANTOCYSDECARB-RXN","compounds":"H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine => CO2 + D-pantetheine 4'-phosphate"}
{"X":19894,"RHEA_ID":16795,"compounds":"CO2 + D-pantetheine 4'-phosphate => H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine"}
{"X":19895,"RHEA_ID":27458,"DIRECTION":"LR","MASTER_ID":27457,"metacyc":"RXN-11331","compounds":"3-iodo-L-tyrosine + iodide + NADP(+) => 3,5-diiodo-L-tyrosine + H(+) + NADPH"}
{"X":19896,"RHEA_ID":16801,"DIRECTION":"UN","MASTER_ID":16801,"ec":"2.8.2.20","compounds":"3'-phosphoadenylyl sulfate + L-tyrosyl-[protein] = adenosine 3',5'-bisphosphate + H(+) + O-sulfo-L-tyrosine-[protein]"}
{"X":19897,"RHEA_ID":16802,"compounds":"3'-phosphoadenylyl sulfate + L-tyrosyl-[protein] => adenosine 3',5'-bisphosphate + H(+) + O-sulfo-L-tyrosine-[protein]"}
{"X":19898,"RHEA_ID":16803,"compounds":"adenosine 3',5'-bisphosphate + H(+) + O-sulfo-L-tyrosine-[protein] => 3'-phosphoadenylyl sulfate + L-tyrosyl-[protein]"}
{"X":19899,"RHEA_ID":27462,"DIRECTION":"LR","MASTER_ID":27461,"metacyc":"RXN-11363","compounds":"D-glycero-alpha-D-manno-heptose 1-phosphate + GTP + H(+) => diphosphate + GDP-D-glycero-alpha-D-manno-heptose"}
{"X":19900,"RHEA_ID":16805,"DIRECTION":"UN","MASTER_ID":16805,"ec":"1.14.11.26","compounds":"2-oxoglutarate + deacetoxycephalosporin C + O2 = CO2 + deacetylcephalosporin C + succinate"}
{"X":19901,"RHEA_ID":16806,"DIRECTION":"LR","MASTER_ID":16805,"metacyc":"1.14.11.26-RXN","compounds":"2-oxoglutarate + deacetoxycephalosporin C + O2 => CO2 + deacetylcephalosporin C + succinate"}
{"X":19902,"RHEA_ID":16807,"compounds":"CO2 + deacetylcephalosporin C + succinate => 2-oxoglutarate + deacetoxycephalosporin C + O2"}
{"X":19903,"RHEA_ID":27466,"DIRECTION":"LR","MASTER_ID":27465,"ecocyc":"RXN0-4342","metacyc":"RXN0-4342","compounds":"ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) => ADP-D-glycero-beta-D-manno-heptose + diphosphate"}
{"X":19904,"RHEA_ID":16809,"DIRECTION":"UN","MASTER_ID":16809,"ec":"4.1.3.30","compounds":"(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate"}
{"X":19905,"RHEA_ID":16810,"DIRECTION":"LR","MASTER_ID":16809,"macie":"M0182","compounds":"(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate => pyruvate + succinate"}
{"X":19906,"RHEA_ID":16811,"compounds":"pyruvate + succinate => (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate"}
{"X":19907,"RHEA_ID":27470,"DIRECTION":"LR","MASTER_ID":27469,"metacyc":"RXN-11313","compounds":"H2O + N,N'-diacetylchitobiose => acetate + N-acetyl-beta-D-glucosaminyl-(1->4)-D-glucosamine"}
{"X":19908,"RHEA_ID":16813,"DIRECTION":"UN","MASTER_ID":16813,"ec":"3.7.1.3","compounds":"H2O + L-kynurenine = anthranilate + H(+) + L-alanine"}
{"X":19909,"RHEA_ID":16814,"DIRECTION":"LR","MASTER_ID":16813,"metacyc":"KYNURENINASE-RXN","compounds":"H2O + L-kynurenine => anthranilate + H(+) + L-alanine"}
{"X":19910,"RHEA_ID":16815,"compounds":"anthranilate + H(+) + L-alanine => H2O + L-kynurenine"}
{"X":19911,"RHEA_ID":27474,"DIRECTION":"LR","MASTER_ID":27473,"ecocyc":"RXN0-4341","metacyc":"RXN0-4341","compounds":"ATP + D-glycero-beta-D-manno-heptose 7-phosphate => ADP + D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(+)"}
{"X":19912,"RHEA_ID":16817,"DIRECTION":"UN","MASTER_ID":16817,"ec":"1.1.1.43","compounds":"6-phospho-D-gluconate + NADP(+) = 6-phospho-2-dehydro-D-gluconate + H(+) + NADPH"}
{"X":19913,"RHEA_ID":16818,"compounds":"6-phospho-D-gluconate + NADP(+) => 6-phospho-2-dehydro-D-gluconate + H(+) + NADPH"}
{"X":19914,"RHEA_ID":16819,"DIRECTION":"RL","MASTER_ID":16817,"metacyc":"1.1.1.43-RXN","compounds":"6-phospho-2-dehydro-D-gluconate + H(+) + NADPH => 6-phospho-D-gluconate + NADP(+)"}
{"X":19915,"RHEA_ID":27478,"DIRECTION":"LR","MASTER_ID":27477,"metacyc":"RXN-8147","compounds":"2-oxoglutarate + O2 + thebaine => CO2 + formaldehyde + neopinone + succinate"}
{"X":19916,"RHEA_ID":16821,"DIRECTION":"UN","MASTER_ID":16821,"ec":"1.1.1.43","compounds":"6-phospho-D-gluconate + NAD(+) = 6-phospho-2-dehydro-D-gluconate + H(+) + NADH"}
{"X":19917,"RHEA_ID":16822,"compounds":"6-phospho-D-gluconate + NAD(+) => 6-phospho-2-dehydro-D-gluconate + H(+) + NADH"}
{"X":19918,"RHEA_ID":16823,"DIRECTION":"RL","MASTER_ID":16821,"metacyc":"1.1.1.43-RXN","compounds":"6-phospho-2-dehydro-D-gluconate + H(+) + NADH => 6-phospho-D-gluconate + NAD(+)"}
{"X":19919,"RHEA_ID":27482,"DIRECTION":"LR","MASTER_ID":27481,"metacyc":"RXN-9689","compounds":"(S)-columbianetin + O2 + reduced [NADPH--hemoprotein reductase] => acetone + angelicin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":19920,"RHEA_ID":16825,"DIRECTION":"UN","MASTER_ID":16825,"ec":"2.7.1.48","compounds":"ATP + uridine = ADP + H(+) + UMP"}
{"X":19921,"RHEA_ID":16826,"DIRECTION":"LR","MASTER_ID":16825,"ecocyc":"URIDINEKIN-RXN","metacyc":"URIDINEKIN-RXN","compounds":"ATP + uridine => ADP + H(+) + UMP"}
{"X":19922,"RHEA_ID":16827,"compounds":"ADP + H(+) + UMP => ATP + uridine"}
{"X":19923,"RHEA_ID":27486,"DIRECTION":"LR","MASTER_ID":27485,"ecocyc":"ALLANTOATE-DEIMINASE-RXN","metacyc":"ALLANTOATE-DEIMINASE-RXN","compounds":"allantoate + 2 H(+) + H2O => (S)-2-ureidoglycine + CO2 + NH4(+)"}
{"X":19924,"RHEA_ID":16829,"DIRECTION":"UN","MASTER_ID":16829,"ec":"1.2.3.1","compounds":"an aldehyde + H2O + O2 = a carboxylate + H(+) + H2O2"}
{"X":19925,"RHEA_ID":16830,"DIRECTION":"LR","MASTER_ID":16829,"metacyc":"ALDEHYDE-OXIDASE-RXN","compounds":"an aldehyde + H2O + O2 => a carboxylate + H(+) + H2O2"}
{"X":19926,"RHEA_ID":16831,"compounds":"a carboxylate + H(+) + H2O2 => an aldehyde + H2O + O2"}
{"X":19927,"RHEA_ID":16833,"DIRECTION":"UN","MASTER_ID":16833,"ec":"1.11.1.9","compounds":"2 glutathione + H2O2 = glutathione disulfide + 2 H2O"}
{"X":19928,"RHEA_ID":16834,"DIRECTION":"LR","MASTER_ID":16833,"ecocyc":"GLUTATHIONE-PEROXIDASE-RXN","metacyc":"GLUTATHIONE-PEROXIDASE-RXN","reactome":"R-HSA-3341277.2","compounds":"2 glutathione + H2O2 => glutathione disulfide + 2 H2O"}
{"X":19929,"RHEA_ID":16834,"DIRECTION":"LR","MASTER_ID":16833,"ecocyc":"GLUTATHIONE-PEROXIDASE-RXN","metacyc":"GLUTATHIONE-PEROXIDASE-RXN","reactome":"R-HSA-3341397.2","compounds":"2 glutathione + H2O2 => glutathione disulfide + 2 H2O"}
{"X":19930,"RHEA_ID":16834,"DIRECTION":"LR","MASTER_ID":16833,"ecocyc":"GLUTATHIONE-PEROXIDASE-RXN","metacyc":"GLUTATHIONE-PEROXIDASE-RXN","reactome":"R-HSA-71676.2","compounds":"2 glutathione + H2O2 => glutathione disulfide + 2 H2O"}
{"X":19931,"RHEA_ID":16834,"DIRECTION":"LR","MASTER_ID":16833,"ecocyc":"GLUTATHIONE-PEROXIDASE-RXN","metacyc":"GLUTATHIONE-PEROXIDASE-RXN","reactome":"R-HSA-3343700.2","compounds":"2 glutathione + H2O2 => glutathione disulfide + 2 H2O"}
{"X":19932,"RHEA_ID":16834,"DIRECTION":"LR","MASTER_ID":16833,"ecocyc":"GLUTATHIONE-PEROXIDASE-RXN","metacyc":"GLUTATHIONE-PEROXIDASE-RXN","reactome":"R-HSA-3323013.1","compounds":"2 glutathione + H2O2 => glutathione disulfide + 2 H2O"}
{"X":19933,"RHEA_ID":16835,"compounds":"glutathione disulfide + 2 H2O => 2 glutathione + H2O2"}
{"X":19934,"RHEA_ID":27498,"DIRECTION":"LR","MASTER_ID":27497,"metacyc":"RXN-11583","compounds":"3'-O-methyltricetin + S-adenosyl-L-methionine => 3',5'-di-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine"}
{"X":19935,"RHEA_ID":16837,"DIRECTION":"UN","MASTER_ID":16837,"ec":"3.6.1.20","metacyc":"5-ACYLPHOSPHOADENOSINE-HYDROLASE-RXN","compounds":"5'-acylphosphoadenosine + H2O = a carboxylate + AMP + 2 H(+)"}
{"X":19936,"RHEA_ID":16838,"compounds":"5'-acylphosphoadenosine + H2O => a carboxylate + AMP + 2 H(+)"}
{"X":19937,"RHEA_ID":16839,"compounds":"a carboxylate + AMP + 2 H(+) => 5'-acylphosphoadenosine + H2O"}
{"X":19938,"RHEA_ID":16841,"DIRECTION":"UN","MASTER_ID":16841,"ec":"2.1.1.130","compounds":"precorrin-2 + S-adenosyl-L-methionine = H(+) + precorrin-3A + S-adenosyl-L-homocysteine"}
{"X":19939,"RHEA_ID":16842,"compounds":"precorrin-2 + S-adenosyl-L-methionine => H(+) + precorrin-3A + S-adenosyl-L-homocysteine"}
{"X":19940,"RHEA_ID":16843,"compounds":"H(+) + precorrin-3A + S-adenosyl-L-homocysteine => precorrin-2 + S-adenosyl-L-methionine"}
{"X":19941,"RHEA_ID":27507,"DIRECTION":"LR","MASTER_ID":27506,"metacyc":"RXN-11192","compounds":"cocaine + H2O => benzoate + ecgonine methyl ester + H(+)"}
{"X":19942,"RHEA_ID":16845,"DIRECTION":"UN","MASTER_ID":16845,"ec":"2.3.3.3","compounds":"acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)"}
{"X":19943,"RHEA_ID":16845,"DIRECTION":"UN","MASTER_ID":16845,"ec":"2.3.3.1","compounds":"acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)"}
{"X":19944,"RHEA_ID":16845,"DIRECTION":"UN","MASTER_ID":16845,"ec":"2.3.3.16","compounds":"acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)"}
{"X":19945,"RHEA_ID":16846,"DIRECTION":"LR","MASTER_ID":16845,"ecocyc":"CITSYN-RXN","macie":"M0078","metacyc":"CITSYN-RXN","reactome":"R-HSA-70975.2","compounds":"acetyl-CoA + H2O + oxaloacetate => citrate + CoA + H(+)"}
{"X":19946,"RHEA_ID":16847,"compounds":"citrate + CoA + H(+) => acetyl-CoA + H2O + oxaloacetate"}
{"X":19947,"RHEA_ID":27513,"DIRECTION":"BI","MASTER_ID":27510,"metacyc":"RXN-8078","compounds":"7,8-didemethyl-8-hydroxy-5-deazariboflavin + enolpyruvoyl-2-diphospho-5'-guanosine <=> dehydro F420-0 + GMP + H(+)"}
{"X":19948,"RHEA_ID":16853,"DIRECTION":"UN","MASTER_ID":16853,"ec":"4.3.2.2","compounds":"N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate"}
{"X":19949,"RHEA_ID":16854,"DIRECTION":"LR","MASTER_ID":16853,"ecocyc":"AMPSYN-RXN","macie":"M0080","reactome":"R-HSA-73828.2","compounds":"N(6)-(1,2-dicarboxyethyl)-AMP => AMP + fumarate"}
{"X":19950,"RHEA_ID":16855,"compounds":"AMP + fumarate => N(6)-(1,2-dicarboxyethyl)-AMP"}
{"X":19951,"RHEA_ID":37367,"DIRECTION":"UN","MASTER_ID":37367,"ec":"2.7.8.38","compounds":"CDP-2,3-bis-(O-phytanyl)-sn-glycerol + L-serine = 2,3-bis-O-phytanyl-sn-glycero-3-phospho-L-serine + CMP + H(+)"}
{"X":19952,"RHEA_ID":16857,"DIRECTION":"UN","MASTER_ID":16857,"ec":"2.1.1.113","compounds":"a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":19953,"RHEA_ID":16858,"DIRECTION":"LR","MASTER_ID":16857,"metacyc":"2.1.1.113-RXN","compounds":"a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine => an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":19954,"RHEA_ID":16859,"compounds":"an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine => a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine"}
{"X":19955,"RHEA_ID":27519,"DIRECTION":"LR","MASTER_ID":27518,"metacyc":"RXN3DJ-25","reactome":"R-HSA-428690.1","compounds":"H2O + sphing-4-enine 1-phosphate => phosphate + sphing-4-enine"}
{"X":19956,"RHEA_ID":16861,"DIRECTION":"UN","MASTER_ID":16861,"ec":"2.6.1.62","compounds":"8-amino-7-oxononanoate + S-adenosyl-L-methionine = 7,8-diaminononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate"}
{"X":19957,"RHEA_ID":16862,"DIRECTION":"LR","MASTER_ID":16861,"macie":"M0249","compounds":"8-amino-7-oxononanoate + S-adenosyl-L-methionine => 7,8-diaminononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate"}
{"X":19958,"RHEA_ID":16863,"compounds":"7,8-diaminononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate => 8-amino-7-oxononanoate + S-adenosyl-L-methionine"}
{"X":19959,"RHEA_ID":27523,"DIRECTION":"LR","MASTER_ID":27522,"metacyc":"1.13.11.9-RXN","compounds":"2,5-dihydroxypyridine + O2 => H(+) + N-formylmaleamate"}
{"X":19960,"RHEA_ID":16865,"DIRECTION":"UN","MASTER_ID":16865,"ec":"2.3.1.176","compounds":"choloyl-CoA + propanoyl-CoA = 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + CoA"}
{"X":19961,"RHEA_ID":16866,"compounds":"choloyl-CoA + propanoyl-CoA => 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + CoA"}
{"X":19962,"RHEA_ID":16867,"DIRECTION":"RL","MASTER_ID":16865,"metacyc":"2.3.1.176-RXN","reactome":"R-HSA-192341.1","compounds":"3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + CoA => choloyl-CoA + propanoyl-CoA"}
{"X":19963,"RHEA_ID":27527,"DIRECTION":"LR","MASTER_ID":27526,"metacyc":"RXN-8617","compounds":"(2E,6E)-farnesyl diphosphate + H2O => (2E,6E)-farnesol + diphosphate"}
{"X":19964,"RHEA_ID":16869,"DIRECTION":"UN","MASTER_ID":16869,"ec":"1.13.11.33","compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate"}
{"X":19965,"RHEA_ID":16870,"DIRECTION":"LR","MASTER_ID":16869,"metacyc":"ARACHIDONATE-15-LIPOXYGENASE-RXN","reactome":"R-HSA-2162002.2","compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate"}
{"X":19966,"RHEA_ID":16871,"compounds":"(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2"}
{"X":19967,"RHEA_ID":27531,"DIRECTION":"LR","MASTER_ID":27530,"metacyc":"RXN-8616","compounds":"(2E,6E)-farnesyl diphosphate + H2O => (3S,6E)-nerolidol + diphosphate"}
{"X":19968,"RHEA_ID":16873,"DIRECTION":"UN","MASTER_ID":16873,"ec":"2.1.1.74","compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + FADH2 + uridine(54) in tRNA = (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + FAD + H(+)"}
{"X":19969,"RHEA_ID":16874,"DIRECTION":"LR","MASTER_ID":16873,"metacyc":"2.1.1.74-RXN","compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + FADH2 + uridine(54) in tRNA => (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + FAD + H(+)"}
{"X":19970,"RHEA_ID":16875,"compounds":"(6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + FAD + H(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + FADH2 + uridine(54) in tRNA"}
{"X":19971,"RHEA_ID":27535,"DIRECTION":"LR","MASTER_ID":27534,"metacyc":"RXN-11575","compounds":"(2E,6E)-farnesyl diphosphate + H2O => (3R,6E)-nerolidol + diphosphate"}
{"X":19972,"RHEA_ID":16877,"DIRECTION":"UN","MASTER_ID":16877,"ec":"4.1.1.29","compounds":"3-sulfino-L-alanine + H(+) = CO2 + hypotaurine"}
{"X":19973,"RHEA_ID":16878,"DIRECTION":"LR","MASTER_ID":16877,"metacyc":"SULFINOALANINE-DECARBOXYLASE-RXN","reactome":"R-HSA-6814165.2","compounds":"3-sulfino-L-alanine + H(+) => CO2 + hypotaurine"}
{"X":19974,"RHEA_ID":16878,"DIRECTION":"LR","MASTER_ID":16877,"metacyc":"SULFINOALANINE-DECARBOXYLASE-RXN","reactome":"R-HSA-1655443.3","compounds":"3-sulfino-L-alanine + H(+) => CO2 + hypotaurine"}
{"X":19975,"RHEA_ID":16879,"compounds":"CO2 + hypotaurine => 3-sulfino-L-alanine + H(+)"}
{"X":19976,"RHEA_ID":27540,"compounds":"4-(hydroxylamino)-N,N-dimethylaniline + acetaldehyde => ethanol + N,N-dimethyl-4-nitrosoaniline"}
{"X":19977,"RHEA_ID":16881,"DIRECTION":"UN","MASTER_ID":16881,"ec":"2.8.1.1","compounds":"hydrogen cyanide + thiosulfate = 2 H(+) + sulfite + thiocyanate"}
{"X":19978,"RHEA_ID":16882,"DIRECTION":"LR","MASTER_ID":16881,"ecocyc":"THIOSULFATE-SULFURTRANSFERASE-RXN","macie":"M0153","metacyc":"THIOSULFATE-SULFURTRANSFERASE-RXN","reactome":"R-HSA-9013198.1","compounds":"hydrogen cyanide + thiosulfate => 2 H(+) + sulfite + thiocyanate"}
{"X":19979,"RHEA_ID":16883,"compounds":"2 H(+) + sulfite + thiocyanate => hydrogen cyanide + thiosulfate"}
{"X":19980,"RHEA_ID":16885,"compounds":"2 bilirubin-glucuronoside = bilirubin IXalpha + bilirubin-bisglucuronoside"}
{"X":19981,"RHEA_ID":16886,"compounds":"2 bilirubin-glucuronoside => bilirubin IXalpha + bilirubin-bisglucuronoside"}
{"X":19982,"RHEA_ID":16887,"compounds":"bilirubin IXalpha + bilirubin-bisglucuronoside => 2 bilirubin-glucuronoside"}
{"X":19983,"RHEA_ID":27548,"compounds":"3-hydroxyanthranilate + FAD + H(+) + H2O => anthranilate + FADH2 + O2"}
{"X":19984,"RHEA_ID":16889,"DIRECTION":"UN","MASTER_ID":16889,"ec":"2.6.1.65","compounds":"2-oxoglutarate + 6-acetamido-3-aminohexanoate = 6-acetamido-3-oxohexanoate + L-glutamate"}
{"X":19985,"RHEA_ID":16890,"compounds":"2-oxoglutarate + 6-acetamido-3-aminohexanoate => 6-acetamido-3-oxohexanoate + L-glutamate"}
{"X":19986,"RHEA_ID":16891,"compounds":"6-acetamido-3-oxohexanoate + L-glutamate => 2-oxoglutarate + 6-acetamido-3-aminohexanoate"}
{"X":19987,"RHEA_ID":27553,"compounds":"di-trans,octa-cis-undecaprenyl diphosphate + 8 diphosphate => (2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate"}
{"X":19988,"RHEA_ID":16893,"DIRECTION":"UN","MASTER_ID":16893,"ec":"2.1.1.87","compounds":"pyridine + S-adenosyl-L-methionine = N-methylpyridinium + S-adenosyl-L-homocysteine"}
{"X":19989,"RHEA_ID":16894,"DIRECTION":"LR","MASTER_ID":16893,"metacyc":"PYRIDINE-N-METHYLTRANSFERASE-RXN","reactome":"R-HSA-175987.3","compounds":"pyridine + S-adenosyl-L-methionine => N-methylpyridinium + S-adenosyl-L-homocysteine"}
{"X":19990,"RHEA_ID":16895,"compounds":"N-methylpyridinium + S-adenosyl-L-homocysteine => pyridine + S-adenosyl-L-methionine"}
{"X":19991,"RHEA_ID":27557,"compounds":"all-trans-hexaprenyl diphosphate + 2 diphosphate => all-trans-geranylgeranyl diphosphate + 2 isopentenyl diphosphate"}
{"X":19992,"RHEA_ID":16897,"DIRECTION":"UN","MASTER_ID":16897,"ec":"2.3.1.77","compounds":"a 3beta-hydroxysteroid + a triacylglycerol = a 3beta-hydroxysteroid ester + a diacylglycerol"}
{"X":19993,"RHEA_ID":16898,"compounds":"a 3beta-hydroxysteroid + a triacylglycerol => a 3beta-hydroxysteroid ester + a diacylglycerol"}
{"X":19994,"RHEA_ID":16899,"compounds":"a 3beta-hydroxysteroid ester + a diacylglycerol => a 3beta-hydroxysteroid + a triacylglycerol"}
{"X":19995,"RHEA_ID":16901,"DIRECTION":"UN","MASTER_ID":16901,"ec":"2.3.1.178","compounds":"acetyl-CoA + L-2,4-diaminobutanoate = (2S)-4-acetamido-2-aminobutanoate + CoA + H(+)"}
{"X":19996,"RHEA_ID":16902,"compounds":"acetyl-CoA + L-2,4-diaminobutanoate => (2S)-4-acetamido-2-aminobutanoate + CoA + H(+)"}
{"X":19997,"RHEA_ID":16903,"compounds":"(2S)-4-acetamido-2-aminobutanoate + CoA + H(+) => acetyl-CoA + L-2,4-diaminobutanoate"}
{"X":19998,"RHEA_ID":27565,"compounds":"all-trans-nonaprenyl diphosphate + 7 diphosphate => (2E)-geranyl diphosphate + 7 isopentenyl diphosphate"}
{"X":19999,"RHEA_ID":16905,"DIRECTION":"UN","MASTER_ID":16905,"ec":"3.3.2.2","compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = a 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine"}
{"X":20000,"RHEA_ID":16906,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O => a 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine"}
{"X":20001,"RHEA_ID":16907,"compounds":"a 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O"}
{"X":20002,"RHEA_ID":16909,"DIRECTION":"UN","MASTER_ID":16909,"ec":"1.4.2.1","compounds":"2 [Fe(III)cytochrome c] + glycine + H2O = 2 [Fe(II)cytochrome c] + glyoxylate + 2 H(+) + NH4(+)"}
{"X":20003,"RHEA_ID":16910,"compounds":"2 [Fe(III)cytochrome c] + glycine + H2O => 2 [Fe(II)cytochrome c] + glyoxylate + 2 H(+) + NH4(+)"}
{"X":20004,"RHEA_ID":16911,"compounds":"2 [Fe(II)cytochrome c] + glyoxylate + 2 H(+) + NH4(+) => 2 [Fe(III)cytochrome c] + glycine + H2O"}
{"X":20005,"RHEA_ID":16913,"DIRECTION":"UN","MASTER_ID":16913,"ec":"2.7.8.8","compounds":"a CDP-1,2-diacyl-sn-glycerol + L-serine = 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)"}
{"X":20006,"RHEA_ID":16914,"compounds":"a CDP-1,2-diacyl-sn-glycerol + L-serine => 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)"}
{"X":20007,"RHEA_ID":16915,"compounds":"1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+) => a CDP-1,2-diacyl-sn-glycerol + L-serine"}
{"X":20008,"RHEA_ID":27580,"compounds":"(R)-piperazine-2-carboxylate + tert-butylamine => (R)-N-tert-butylpiperazine-2-carboxamide + H2O"}
{"X":20009,"RHEA_ID":16917,"DIRECTION":"UN","MASTER_ID":16917,"ec":"1.14.13.10","compounds":"2,6-dihydroxypyridine + H(+) + NADH + O2 = 2,3,6-trihydroxypyridine + H2O + NAD(+)"}
{"X":20010,"RHEA_ID":16918,"DIRECTION":"LR","MASTER_ID":16917,"metacyc":"1.14.13.10-RXN","compounds":"2,6-dihydroxypyridine + H(+) + NADH + O2 => 2,3,6-trihydroxypyridine + H2O + NAD(+)"}
{"X":20011,"RHEA_ID":16919,"compounds":"2,3,6-trihydroxypyridine + H2O + NAD(+) => 2,6-dihydroxypyridine + H(+) + NADH + O2"}
{"X":20012,"RHEA_ID":27584,"compounds":"2-methyleneglutarate + H2O => 2-(hydroxymethyl)glutarate"}
{"X":20013,"RHEA_ID":16921,"DIRECTION":"UN","MASTER_ID":16921,"ec":"2.4.1.155","compounds":"N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP"}
{"X":20014,"RHEA_ID":16922,"DIRECTION":"LR","MASTER_ID":16921,"metacyc":"2.4.1.155-RXN","compounds":"N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP"}
{"X":20015,"RHEA_ID":16923,"compounds":"H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":20016,"RHEA_ID":16925,"DIRECTION":"UN","MASTER_ID":16925,"ec":"2.1.1.104","compounds":"(E)-caffeoyl-CoA + S-adenosyl-L-methionine = (E)-feruloyl-CoA + H(+) + S-adenosyl-L-homocysteine"}
{"X":20017,"RHEA_ID":16926,"DIRECTION":"LR","MASTER_ID":16925,"metacyc":"CAFFEOYL-COA-O-METHYLTRANSFERASE-RXN","compounds":"(E)-caffeoyl-CoA + S-adenosyl-L-methionine => (E)-feruloyl-CoA + H(+) + S-adenosyl-L-homocysteine"}
{"X":20018,"RHEA_ID":16927,"compounds":"(E)-feruloyl-CoA + H(+) + S-adenosyl-L-homocysteine => (E)-caffeoyl-CoA + S-adenosyl-L-methionine"}
{"X":20019,"RHEA_ID":27592,"compounds":"(R)-pantothenate + ADP + H(+) + phosphate => (R)-pantoate + ATP + beta-alanine"}
{"X":20020,"RHEA_ID":16929,"DIRECTION":"UN","MASTER_ID":16929,"ec":"2.3.1.127","metacyc":"ORNITHINE-N-BENZOYLTRANSFERASE-RXN","compounds":"2 benzoyl-CoA + L-ornithine = 2 CoA + 2 H(+) + N(2),N(5)-dibenzoyl-L-ornithine"}
{"X":20021,"RHEA_ID":16930,"compounds":"2 benzoyl-CoA + L-ornithine => 2 CoA + 2 H(+) + N(2),N(5)-dibenzoyl-L-ornithine"}
{"X":20022,"RHEA_ID":16931,"compounds":"2 CoA + 2 H(+) + N(2),N(5)-dibenzoyl-L-ornithine => 2 benzoyl-CoA + L-ornithine"}
{"X":20023,"RHEA_ID":27596,"compounds":"all-trans-nonaprenyl diphosphate + 5 diphosphate => all-trans-geranylgeranyl diphosphate + 5 isopentenyl diphosphate"}
{"X":20024,"RHEA_ID":16933,"DIRECTION":"UN","MASTER_ID":16933,"ec":"3.5.99.7","compounds":"1-aminocyclopropane-1-carboxylate + H2O = 2-oxobutanoate + NH4(+)"}
{"X":20025,"RHEA_ID":16934,"DIRECTION":"LR","MASTER_ID":16933,"metacyc":"4.1.99.4-RXN","compounds":"1-aminocyclopropane-1-carboxylate + H2O => 2-oxobutanoate + NH4(+)"}
{"X":20026,"RHEA_ID":16935,"compounds":"2-oxobutanoate + NH4(+) => 1-aminocyclopropane-1-carboxylate + H2O"}
{"X":20027,"RHEA_ID":27604,"compounds":"di-trans,nona-cis-dodecaprenyl diphosphate + 9 diphosphate => (2Z,6E)-farnesyl diphosphate + 9 isopentenyl diphosphate"}
{"X":20028,"RHEA_ID":16937,"DIRECTION":"UN","MASTER_ID":16937,"ec":"2.7.1.93","metacyc":"ALKYLGLYCEROL-KINASE-RXN","compounds":"1-O-alkyl-sn-glycerol + ATP = 1-O-alkyl-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":20029,"RHEA_ID":16938,"compounds":"1-O-alkyl-sn-glycerol + ATP => 1-O-alkyl-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":20030,"RHEA_ID":16939,"compounds":"1-O-alkyl-sn-glycero-3-phosphate + ADP + H(+) => 1-O-alkyl-sn-glycerol + ATP"}
{"X":20031,"RHEA_ID":27608,"compounds":"1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine"}
{"X":20032,"RHEA_ID":16941,"DIRECTION":"UN","MASTER_ID":16941,"ec":"1.7.3.2","compounds":"N-acetylindoxyl + O2 = H2O + N-acetylisatin"}
{"X":20033,"RHEA_ID":16942,"DIRECTION":"LR","MASTER_ID":16941,"metacyc":"ACETYLINDOXYL-OXIDASE-RXN","compounds":"N-acetylindoxyl + O2 => H2O + N-acetylisatin"}
{"X":20034,"RHEA_ID":16943,"compounds":"H2O + N-acetylisatin => N-acetylindoxyl + O2"}
{"X":20035,"RHEA_ID":27612,"compounds":"CO2 + H2 => formate + H(+)"}
{"X":20036,"RHEA_ID":16945,"DIRECTION":"UN","MASTER_ID":16945,"ec":"2.1.2.10","compounds":"(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)"}
{"X":20037,"RHEA_ID":16946,"DIRECTION":"LR","MASTER_ID":16945,"ecocyc":"GCVT-RXN","metacyc":"GCVT-RXN","compounds":"(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)"}
{"X":20038,"RHEA_ID":16947,"compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+) => (6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein]"}
{"X":20039,"RHEA_ID":27616,"compounds":"di-trans,deca-cis-tridecaprenyl diphosphate + 10 diphosphate => (2Z,6E)-farnesyl diphosphate + 10 isopentenyl diphosphate"}
{"X":20040,"RHEA_ID":16949,"DIRECTION":"UN","MASTER_ID":16949,"ec":"1.1.1.18","compounds":"myo-inositol + NAD(+) = H(+) + NADH + scyllo-inosose"}
{"X":20041,"RHEA_ID":16950,"compounds":"myo-inositol + NAD(+) => H(+) + NADH + scyllo-inosose"}
{"X":20042,"RHEA_ID":16951,"compounds":"H(+) + NADH + scyllo-inosose => myo-inositol + NAD(+)"}
{"X":20043,"RHEA_ID":27620,"compounds":"di-trans,undeca-cis-tetradecaprenyl diphosphate + 11 diphosphate => (2Z,6E)-farnesyl diphosphate + 11 isopentenyl diphosphate"}
{"X":20044,"RHEA_ID":16953,"DIRECTION":"UN","MASTER_ID":16953,"ec":"2.6.1.81","compounds":"2-oxoglutarate + N(2)-succinyl-L-ornithine = L-glutamate + N-succinyl-L-glutamate 5-semialdehyde"}
{"X":20045,"RHEA_ID":16954,"DIRECTION":"LR","MASTER_ID":16953,"ecocyc":"SUCCORNTRANSAM-RXN","metacyc":"SUCCORNTRANSAM-RXN","compounds":"2-oxoglutarate + N(2)-succinyl-L-ornithine => L-glutamate + N-succinyl-L-glutamate 5-semialdehyde"}
{"X":20046,"RHEA_ID":16955,"compounds":"L-glutamate + N-succinyl-L-glutamate 5-semialdehyde => 2-oxoglutarate + N(2)-succinyl-L-ornithine"}
{"X":20047,"RHEA_ID":27624,"compounds":"7 diphosphate + tri-trans,hepta-cis-undecaprenyl diphosphate => geranylgeranyl diphosphate + 7 isopentenyl diphosphate"}
{"X":20048,"RHEA_ID":16957,"DIRECTION":"UN","MASTER_ID":16957,"ec":"3.1.4.35","compounds":"3',5'-cyclic GMP + H2O = GMP + H(+)"}
{"X":20049,"RHEA_ID":16958,"DIRECTION":"LR","MASTER_ID":16957,"metacyc":"35-CYCLIC-GMP-PHOSPHODIESTERASE-RXN","reactome":"R-HSA-74059.1","compounds":"3',5'-cyclic GMP + H2O => GMP + H(+)"}
{"X":20050,"RHEA_ID":16958,"DIRECTION":"LR","MASTER_ID":16957,"metacyc":"35-CYCLIC-GMP-PHOSPHODIESTERASE-RXN","reactome":"R-HSA-4086392.1","compounds":"3',5'-cyclic GMP + H2O => GMP + H(+)"}
{"X":20051,"RHEA_ID":16959,"compounds":"GMP + H(+) => 3',5'-cyclic GMP + H2O"}
{"X":20052,"RHEA_ID":37472,"compounds":"3-methylbutanoyl-CoA + S-adenosyl-L-methionine => CoA + H(+) + N-isovaleryl-L-homoserine lactone + S-methyl-5'-thioadenosine"}
{"X":20053,"RHEA_ID":16961,"DIRECTION":"UN","MASTER_ID":16961,"ec":"4.3.2.8","compounds":"epsilon-(gamma-L-glutamyl)-L-lysine = 5-oxo-L-proline + L-lysine"}
{"X":20054,"RHEA_ID":16962,"DIRECTION":"LR","MASTER_ID":16961,"metacyc":"RXN-19023","compounds":"epsilon-(gamma-L-glutamyl)-L-lysine => 5-oxo-L-proline + L-lysine"}
{"X":20055,"RHEA_ID":16963,"compounds":"5-oxo-L-proline + L-lysine => epsilon-(gamma-L-glutamyl)-L-lysine"}
{"X":20056,"RHEA_ID":16965,"DIRECTION":"UN","MASTER_ID":16965,"ec":"4.2.3.15","compounds":"(2E)-geranyl diphosphate = beta-myrcene + diphosphate"}
{"X":20057,"RHEA_ID":16966,"DIRECTION":"LR","MASTER_ID":16965,"metacyc":"RXN-5110","compounds":"(2E)-geranyl diphosphate => beta-myrcene + diphosphate"}
{"X":20058,"RHEA_ID":16967,"compounds":"beta-myrcene + diphosphate => (2E)-geranyl diphosphate"}
{"X":20059,"RHEA_ID":37480,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":20060,"RHEA_ID":16969,"DIRECTION":"UN","MASTER_ID":16969,"ec":"5.1.3.13","compounds":"dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose"}
{"X":20061,"RHEA_ID":16970,"compounds":"dTDP-4-dehydro-6-deoxy-alpha-D-glucose => dTDP-4-dehydro-beta-L-rhamnose"}
{"X":20062,"RHEA_ID":16971,"compounds":"dTDP-4-dehydro-beta-L-rhamnose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose"}
{"X":20063,"RHEA_ID":37484,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-dodecanoyl-sn-glycero-3-phosphocholine => 1-dodecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":20064,"RHEA_ID":16973,"DIRECTION":"UN","MASTER_ID":16973,"ec":"1.14.99.26","compounds":"2-hydroxypyridine + AH2 + O2 = 2,5-dihydroxypyridine + A + H2O"}
{"X":20065,"RHEA_ID":16974,"DIRECTION":"LR","MASTER_ID":16973,"metacyc":"2-HYDROXYPYRIDINE-5-MONOOXYGENASE-RXN","compounds":"2-hydroxypyridine + AH2 + O2 => 2,5-dihydroxypyridine + A + H2O"}
{"X":20066,"RHEA_ID":16975,"compounds":"2,5-dihydroxypyridine + A + H2O => 2-hydroxypyridine + AH2 + O2"}
{"X":20067,"RHEA_ID":16977,"DIRECTION":"UN","MASTER_ID":16977,"ec":"1.8.1.5","compounds":"acetoacetate + coenzyme M + NADP(+) = 2-oxopropyl-coenzyme M + CO2 + NADPH"}
{"X":20068,"RHEA_ID":16978,"compounds":"acetoacetate + coenzyme M + NADP(+) => 2-oxopropyl-coenzyme M + CO2 + NADPH"}
{"X":20069,"RHEA_ID":16979,"DIRECTION":"RL","MASTER_ID":16977,"metacyc":"1.8.1.5-RXN","compounds":"2-oxopropyl-coenzyme M + CO2 + NADPH => acetoacetate + coenzyme M + NADP(+)"}
{"X":20070,"RHEA_ID":37492,"compounds":"4-coumaroyl-CoA + S-adenosyl-L-methionine => CoA + H(+) + N-(4-coumaroyl)-L-homoserine lactone + S-methyl-5'-thioadenosine"}
{"X":20071,"RHEA_ID":16981,"DIRECTION":"UN","MASTER_ID":16981,"ec":"1.3.1.32","compounds":"3-oxoadipate + NAD(+) = H(+) + maleylacetate + NADH"}
{"X":20072,"RHEA_ID":16982,"compounds":"3-oxoadipate + NAD(+) => H(+) + maleylacetate + NADH"}
{"X":20073,"RHEA_ID":16983,"DIRECTION":"RL","MASTER_ID":16981,"metacyc":"MALEYLACETATE-REDUCTASE-RXN","compounds":"H(+) + maleylacetate + NADH => 3-oxoadipate + NAD(+)"}
{"X":20074,"RHEA_ID":37496,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":20075,"RHEA_ID":16985,"DIRECTION":"UN","MASTER_ID":16985,"ec":"1.3.1.32","compounds":"3-oxoadipate + NADP(+) = H(+) + maleylacetate + NADPH"}
{"X":20076,"RHEA_ID":16986,"compounds":"3-oxoadipate + NADP(+) => H(+) + maleylacetate + NADPH"}
{"X":20077,"RHEA_ID":16987,"DIRECTION":"RL","MASTER_ID":16985,"metacyc":"MALEYLACETATE-REDUCTASE-RXN","compounds":"H(+) + maleylacetate + NADPH => 3-oxoadipate + NADP(+)"}
{"X":20078,"RHEA_ID":37500,"compounds":"(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":20079,"RHEA_ID":16989,"DIRECTION":"UN","MASTER_ID":16989,"ec":"3.1.3.8","compounds":"1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate"}
{"X":20080,"RHEA_ID":16990,"DIRECTION":"LR","MASTER_ID":16989,"ecocyc":"RXN0-1001","metacyc":"RXN0-1001","reactome":"R-HSA-1855225.2","compounds":"1D-myo-inositol hexakisphosphate + H2O => 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate"}
{"X":20081,"RHEA_ID":16990,"DIRECTION":"LR","MASTER_ID":16989,"ecocyc":"RXN0-1001","metacyc":"RXN-10943","reactome":"R-HSA-1855225.2","compounds":"1D-myo-inositol hexakisphosphate + H2O => 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate"}
{"X":20082,"RHEA_ID":16991,"compounds":"1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate => 1D-myo-inositol hexakisphosphate + H2O"}
{"X":20083,"RHEA_ID":27662,"compounds":"(S)-2-hydroxyglutarate + O2 = 2-oxoglutarate + H2O2"}
{"X":20084,"RHEA_ID":16993,"DIRECTION":"UN","MASTER_ID":16993,"ec":"1.8.2.6","compounds":"6 [Fe(III)cytochrome c] + 3 H2O + S-disulfanyl-L-cysteinyl-[SoxY protein] = 6 [Fe(II)cytochrome c] + 7 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]"}
{"X":20085,"RHEA_ID":16994,"DIRECTION":"LR","MASTER_ID":16993,"metacyc":"RXN-18798","compounds":"6 [Fe(III)cytochrome c] + 3 H2O + S-disulfanyl-L-cysteinyl-[SoxY protein] => 6 [Fe(II)cytochrome c] + 7 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]"}
{"X":20086,"RHEA_ID":16995,"compounds":"6 [Fe(II)cytochrome c] + 7 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein] => 6 [Fe(III)cytochrome c] + 3 H2O + S-disulfanyl-L-cysteinyl-[SoxY protein]"}
{"X":20087,"RHEA_ID":16997,"DIRECTION":"UN","MASTER_ID":16997,"ec":"2.8.2.31","metacyc":"2.8.2.31-RXN","compounds":"3'-phosphoadenylyl sulfate + 5alpha-cholane-3alpha,7alpha,12alpha,24-tetrol = 3alpha,7alpha,12alpha-trihydroxy-5alpha-cholan-24-yl sulfate + adenosine 3',5'-bisphosphate + H(+)"}
{"X":20088,"RHEA_ID":16998,"compounds":"3'-phosphoadenylyl sulfate + 5alpha-cholane-3alpha,7alpha,12alpha,24-tetrol => 3alpha,7alpha,12alpha-trihydroxy-5alpha-cholan-24-yl sulfate + adenosine 3',5'-bisphosphate + H(+)"}
{"X":20089,"RHEA_ID":16999,"compounds":"3alpha,7alpha,12alpha-trihydroxy-5alpha-cholan-24-yl sulfate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 5alpha-cholane-3alpha,7alpha,12alpha,24-tetrol"}
{"X":20090,"RHEA_ID":27670,"DIRECTION":"UN","MASTER_ID":27670,"ec":"3.1.3.25","compounds":"1D-myo-inositol 1-phosphate + H2O = myo-inositol + phosphate"}
{"X":20091,"RHEA_ID":17001,"DIRECTION":"UN","MASTER_ID":17001,"ec":"3.5.3.22","compounds":"amidinoproclavaminate + H2O = proclavaminate + urea"}
{"X":20092,"RHEA_ID":17002,"DIRECTION":"LR","MASTER_ID":17001,"metacyc":"3.5.3.22-RXN","compounds":"amidinoproclavaminate + H2O => proclavaminate + urea"}
{"X":20093,"RHEA_ID":17003,"compounds":"proclavaminate + urea => amidinoproclavaminate + H2O"}
{"X":20094,"RHEA_ID":27674,"DIRECTION":"UN","MASTER_ID":27674,"ec":"2.7.4.6","compounds":"ATP + dADP = ADP + dATP"}
{"X":20095,"RHEA_ID":17005,"DIRECTION":"UN","MASTER_ID":17005,"ec":"2.7.1.43","compounds":"ATP + D-glucuronate = 1-phospho-alpha-D-glucuronate + ADP + H(+)"}
{"X":20096,"RHEA_ID":17006,"DIRECTION":"LR","MASTER_ID":17005,"metacyc":"GLUCURONOKINASE-RXN","compounds":"ATP + D-glucuronate => 1-phospho-alpha-D-glucuronate + ADP + H(+)"}
{"X":20097,"RHEA_ID":17007,"compounds":"1-phospho-alpha-D-glucuronate + ADP + H(+) => ATP + D-glucuronate"}
{"X":20098,"RHEA_ID":27678,"DIRECTION":"UN","MASTER_ID":27678,"ec":"2.7.4.6","compounds":"ATP + dCDP = ADP + dCTP"}
{"X":20099,"RHEA_ID":17009,"DIRECTION":"UN","MASTER_ID":17009,"ec":"6.2.1.26","compounds":"2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate"}
{"X":20100,"RHEA_ID":17010,"DIRECTION":"LR","MASTER_ID":17009,"ecocyc":"O-SUCCINYLBENZOATE-COA-LIG-RXN","metacyc":"O-SUCCINYLBENZOATE-COA-LIG-RXN","compounds":"2-succinylbenzoate + ATP + CoA => 2-succinylbenzoyl-CoA + AMP + diphosphate"}
{"X":20101,"RHEA_ID":17011,"compounds":"2-succinylbenzoyl-CoA + AMP + diphosphate => 2-succinylbenzoate + ATP + CoA"}
{"X":20102,"RHEA_ID":27682,"DIRECTION":"UN","MASTER_ID":27682,"ec":"2.7.4.6","compounds":"ATP + dTDP = ADP + dTTP"}
{"X":20103,"RHEA_ID":17013,"DIRECTION":"UN","MASTER_ID":17013,"ec":"5.4.2.9","compounds":"H(+) + phosphoenolpyruvate = 3-phosphonopyruvate"}
{"X":20104,"RHEA_ID":17014,"DIRECTION":"LR","MASTER_ID":17013,"macie":"M0271","compounds":"H(+) + phosphoenolpyruvate => 3-phosphonopyruvate"}
{"X":20105,"RHEA_ID":17015,"compounds":"3-phosphonopyruvate => H(+) + phosphoenolpyruvate"}
{"X":20106,"RHEA_ID":27686,"DIRECTION":"UN","MASTER_ID":27686,"ec":"2.7.4.6","compounds":"ATP + GDP = ADP + GTP"}
{"X":20107,"RHEA_ID":17017,"DIRECTION":"UN","MASTER_ID":17017,"ec":"2.3.1.12","compounds":"(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA"}
{"X":20108,"RHEA_ID":17018,"compounds":"(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA => (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA"}
{"X":20109,"RHEA_ID":17019,"DIRECTION":"RL","MASTER_ID":17017,"ecocyc":"RXN0-1133","compounds":"(R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA => (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA"}
{"X":20110,"RHEA_ID":27690,"DIRECTION":"UN","MASTER_ID":27690,"ec":"2.7.4.6","compounds":"ATP + dGDP = ADP + dGTP"}
{"X":20111,"RHEA_ID":17021,"DIRECTION":"UN","MASTER_ID":17021,"ec":"2.6.1.37","compounds":"(2-aminoethyl)phosphonate + pyruvate = L-alanine + phosphonoacetaldehyde"}
{"X":20112,"RHEA_ID":17022,"compounds":"(2-aminoethyl)phosphonate + pyruvate => L-alanine + phosphonoacetaldehyde"}
{"X":20113,"RHEA_ID":17023,"compounds":"L-alanine + phosphonoacetaldehyde => (2-aminoethyl)phosphonate + pyruvate"}
{"X":20114,"RHEA_ID":27694,"DIRECTION":"UN","MASTER_ID":27694,"ec":"4.2.1.9","compounds":"(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O"}
{"X":20115,"RHEA_ID":17025,"DIRECTION":"UN","MASTER_ID":17025,"ec":"1.1.1.10","compounds":"NADP(+) + xylitol = H(+) + L-xylulose + NADPH"}
{"X":20116,"RHEA_ID":17026,"compounds":"NADP(+) + xylitol => H(+) + L-xylulose + NADPH"}
{"X":20117,"RHEA_ID":17027,"DIRECTION":"RL","MASTER_ID":17025,"reactome":"R-HSA-5661240.2","compounds":"H(+) + L-xylulose + NADPH => NADP(+) + xylitol"}
{"X":20118,"RHEA_ID":27698,"DIRECTION":"UN","MASTER_ID":27698,"ec":"2.7.7.69","compounds":"GDP-beta-L-galactose + phosphate = beta-L-galactose 1-phosphate + GDP + H(+)"}
{"X":20119,"RHEA_ID":17029,"DIRECTION":"UN","MASTER_ID":17029,"ec":"3.5.2.5","compounds":"(S)-allantoin + H2O = allantoate + H(+)"}
{"X":20120,"RHEA_ID":17030,"DIRECTION":"LR","MASTER_ID":17029,"ecocyc":"ALLANTOINASE-RXN","metacyc":"ALLANTOINASE-RXN","compounds":"(S)-allantoin + H2O => allantoate + H(+)"}
{"X":20121,"RHEA_ID":17031,"compounds":"allantoate + H(+) => (S)-allantoin + H2O"}
{"X":20122,"RHEA_ID":27702,"DIRECTION":"UN","MASTER_ID":27702,"ec":"5.3.1.12","compounds":"aldehydo-D-galacturonate = keto-D-tagaturonate"}
{"X":20123,"RHEA_ID":17033,"DIRECTION":"UN","MASTER_ID":17033,"ec":"1.3.1.56","compounds":"(2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+) = biphenyl-2,3-diol + H(+) + NADH"}
{"X":20124,"RHEA_ID":17034,"DIRECTION":"LR","MASTER_ID":17033,"metacyc":"1.3.1.56-RXN","compounds":"(2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+) => biphenyl-2,3-diol + H(+) + NADH"}
{"X":20125,"RHEA_ID":17035,"compounds":"biphenyl-2,3-diol + H(+) + NADH => (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+)"}
{"X":20126,"RHEA_ID":27706,"DIRECTION":"UN","MASTER_ID":27706,"ec":"6.3.2.35","compounds":"ATP + D-alanine + D-serine = ADP + D-alanyl-D-serine + H(+) + phosphate"}
{"X":20127,"RHEA_ID":17037,"DIRECTION":"UN","MASTER_ID":17037,"ec":"1.1.1.191","compounds":"indole-3-ethanol + NADP(+) = H(+) + indole-3-acetaldehyde + NADPH"}
{"X":20128,"RHEA_ID":17038,"compounds":"indole-3-ethanol + NADP(+) => H(+) + indole-3-acetaldehyde + NADPH"}
{"X":20129,"RHEA_ID":17039,"compounds":"H(+) + indole-3-acetaldehyde + NADPH => indole-3-ethanol + NADP(+)"}
{"X":20130,"RHEA_ID":27710,"compounds":"ATP + guanosine = ADP + GMP + H(+)"}
{"X":20131,"RHEA_ID":17041,"DIRECTION":"UN","MASTER_ID":17041,"ec":"3.6.2.1","compounds":"adenosine 5'-phosphosulfate + H2O = AMP + 2 H(+) + sulfate"}
{"X":20132,"RHEA_ID":17042,"DIRECTION":"LR","MASTER_ID":17041,"metacyc":"ADENYLYLSULFATASE-RXN","compounds":"adenosine 5'-phosphosulfate + H2O => AMP + 2 H(+) + sulfate"}
{"X":20133,"RHEA_ID":17043,"compounds":"AMP + 2 H(+) + sulfate => adenosine 5'-phosphosulfate + H2O"}
{"X":20134,"RHEA_ID":27714,"compounds":"GMP + H2O = guanosine + phosphate"}
{"X":20135,"RHEA_ID":17045,"compounds":"1,2-bis-(3,4-dimethoxyphenyl)propane-1,3-diol + H2O2 = 1-(3,4-dimethoxyphenyl)ethane-1,2-diol + 3,4-dimethoxybenzaldehyde + H2O"}
{"X":20136,"RHEA_ID":17046,"compounds":"1,2-bis-(3,4-dimethoxyphenyl)propane-1,3-diol + H2O2 => 1-(3,4-dimethoxyphenyl)ethane-1,2-diol + 3,4-dimethoxybenzaldehyde + H2O"}
{"X":20137,"RHEA_ID":17047,"compounds":"1-(3,4-dimethoxyphenyl)ethane-1,2-diol + 3,4-dimethoxybenzaldehyde + H2O => 1,2-bis-(3,4-dimethoxyphenyl)propane-1,3-diol + H2O2"}
{"X":20138,"RHEA_ID":27716,"compounds":"guanosine + phosphate => GMP + H2O"}
{"X":20139,"RHEA_ID":17049,"DIRECTION":"UN","MASTER_ID":17049,"ec":"2.1.1.64","compounds":"3-demethylubiquinol-9 + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + ubiquinol-9"}
{"X":20140,"RHEA_ID":17050,"DIRECTION":"LR","MASTER_ID":17049,"metacyc":"2.1.1.64-RXN","compounds":"3-demethylubiquinol-9 + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + ubiquinol-9"}
{"X":20141,"RHEA_ID":17051,"compounds":"H(+) + S-adenosyl-L-homocysteine + ubiquinol-9 => 3-demethylubiquinol-9 + S-adenosyl-L-methionine"}
{"X":20142,"RHEA_ID":27720,"compounds":"inosine + phosphate => H2O + IMP"}
{"X":20143,"RHEA_ID":17053,"DIRECTION":"UN","MASTER_ID":17053,"ec":"2.2.1.2","compounds":"D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = beta-D-fructose 6-phosphate + D-erythrose 4-phosphate"}
{"X":20144,"RHEA_ID":17054,"compounds":"D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate => beta-D-fructose 6-phosphate + D-erythrose 4-phosphate"}
{"X":20145,"RHEA_ID":17055,"compounds":"beta-D-fructose 6-phosphate + D-erythrose 4-phosphate => D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate"}
{"X":20146,"RHEA_ID":27724,"compounds":"4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + UDP => di-trans,octa-cis-undecaprenyl phosphate + UDP-4-deoxy-4-formamido-beta-L-arabinose"}
{"X":20147,"RHEA_ID":17057,"DIRECTION":"UN","MASTER_ID":17057,"ec":"2.3.1.141","metacyc":"2.3.1.141-RXN","compounds":"a 2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + a fatty acyl-[ACP] = a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + holo-[ACP]"}
{"X":20148,"RHEA_ID":17058,"compounds":"a 2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + a fatty acyl-[ACP] => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + holo-[ACP]"}
{"X":20149,"RHEA_ID":17059,"compounds":"a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + holo-[ACP] => a 2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + a fatty acyl-[ACP]"}
{"X":20150,"RHEA_ID":17061,"DIRECTION":"UN","MASTER_ID":17061,"ec":"1.14.13.7","compounds":"H(+) + NADPH + O2 + phenol = catechol + H2O + NADP(+)"}
{"X":20151,"RHEA_ID":17062,"DIRECTION":"LR","MASTER_ID":17061,"metacyc":"PHENOL-2-MONOOXYGENASE-RXN","compounds":"H(+) + NADPH + O2 + phenol => catechol + H2O + NADP(+)"}
{"X":20152,"RHEA_ID":17063,"compounds":"catechol + H2O + NADP(+) => H(+) + NADPH + O2 + phenol"}
{"X":20153,"RHEA_ID":27732,"compounds":"beta-L-Ara4N-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl phosphate => 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A (E. coli)"}
{"X":20154,"RHEA_ID":17065,"DIRECTION":"UN","MASTER_ID":17065,"ec":"2.7.1.36","compounds":"(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)"}
{"X":20155,"RHEA_ID":17066,"DIRECTION":"LR","MASTER_ID":17065,"reactome":"R-HSA-191380.1","compounds":"(R)-mevalonate + ATP => (R)-5-phosphomevalonate + ADP + H(+)"}
{"X":20156,"RHEA_ID":17067,"compounds":"(R)-5-phosphomevalonate + ADP + H(+) => (R)-mevalonate + ATP"}
{"X":20157,"RHEA_ID":27736,"compounds":"4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + formate => 4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + H2O"}
{"X":20158,"RHEA_ID":17069,"compounds":"all-trans-undecaprenyl diphosphate + H2O = all-trans-undecaprenyl phosphate + H(+) + phosphate"}
{"X":20159,"RHEA_ID":17070,"compounds":"all-trans-undecaprenyl diphosphate + H2O => all-trans-undecaprenyl phosphate + H(+) + phosphate"}
{"X":20160,"RHEA_ID":17071,"compounds":"all-trans-undecaprenyl phosphate + H(+) + phosphate => all-trans-undecaprenyl diphosphate + H2O"}
{"X":20161,"RHEA_ID":17072,"compounds":"all-trans-undecaprenyl diphosphate + H2O <=> all-trans-undecaprenyl phosphate + H(+) + phosphate"}
{"X":20162,"RHEA_ID":17073,"DIRECTION":"UN","MASTER_ID":17073,"ec":"2.3.1.27","metacyc":"CORTISOL-O-ACETYLTRANSFERASE-RXN","compounds":"acetyl-CoA + cortisol = CoA + cortisol 21-acetate"}
{"X":20163,"RHEA_ID":17074,"compounds":"acetyl-CoA + cortisol => CoA + cortisol 21-acetate"}
{"X":20164,"RHEA_ID":17075,"compounds":"CoA + cortisol 21-acetate => acetyl-CoA + cortisol"}
{"X":20165,"RHEA_ID":27744,"compounds":"2-deoxy-alpha-D-ribose 1-phosphate + adenine => 2'-deoxyadenosine + phosphate"}
{"X":20166,"RHEA_ID":17077,"DIRECTION":"UN","MASTER_ID":17077,"ec":"1.5.3.10","compounds":"H2O + N,N-dimethylglycine + O2 = formaldehyde + H2O2 + sarcosine"}
{"X":20167,"RHEA_ID":17078,"compounds":"H2O + N,N-dimethylglycine + O2 => formaldehyde + H2O2 + sarcosine"}
{"X":20168,"RHEA_ID":17079,"compounds":"formaldehyde + H2O2 + sarcosine => H2O + N,N-dimethylglycine + O2"}
{"X":20169,"RHEA_ID":17081,"DIRECTION":"UN","MASTER_ID":17081,"ec":"2.1.1.146","compounds":"S-adenosyl-L-methionine + trans-isoeugenol = H(+) + S-adenosyl-L-homocysteine + trans-isomethyleugenol"}
{"X":20170,"RHEA_ID":17081,"DIRECTION":"UN","MASTER_ID":17081,"ec":"2.1.1.279","compounds":"S-adenosyl-L-methionine + trans-isoeugenol = H(+) + S-adenosyl-L-homocysteine + trans-isomethyleugenol"}
{"X":20171,"RHEA_ID":17082,"DIRECTION":"LR","MASTER_ID":17081,"metacyc":"2.1.1.146-RXN","compounds":"S-adenosyl-L-methionine + trans-isoeugenol => H(+) + S-adenosyl-L-homocysteine + trans-isomethyleugenol"}
{"X":20172,"RHEA_ID":17083,"compounds":"H(+) + S-adenosyl-L-homocysteine + trans-isomethyleugenol => S-adenosyl-L-methionine + trans-isoeugenol"}
{"X":20173,"RHEA_ID":37602,"compounds":"(9Z,12Z)-hexadecadienoyl-CoA + AH2 + O2 <=> (9Z,12Z,15Z)-hexadecatrienoyl-CoA + A + 2 H2O"}
{"X":20174,"RHEA_ID":17085,"DIRECTION":"UN","MASTER_ID":17085,"ec":"1.1.99.42","compounds":"4-pyridoxate + A = 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + AH2"}
{"X":20175,"RHEA_ID":17086,"DIRECTION":"LR","MASTER_ID":17085,"metacyc":"RXN-8757","compounds":"4-pyridoxate + A => 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + AH2"}
{"X":20176,"RHEA_ID":17087,"compounds":"5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + AH2 => 4-pyridoxate + A"}
{"X":20177,"RHEA_ID":17088,"compounds":"4-pyridoxate + A <=> 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + AH2"}
{"X":20178,"RHEA_ID":17089,"DIRECTION":"UN","MASTER_ID":17089,"ec":"4.1.2.14","compounds":"2-dehydro-3-deoxy-6-phospho-D-gluconate = D-glyceraldehyde 3-phosphate + pyruvate"}
{"X":20179,"RHEA_ID":17089,"DIRECTION":"UN","MASTER_ID":17089,"ec":"4.1.2.55","compounds":"2-dehydro-3-deoxy-6-phospho-D-gluconate = D-glyceraldehyde 3-phosphate + pyruvate"}
{"X":20180,"RHEA_ID":17090,"DIRECTION":"LR","MASTER_ID":17089,"ecocyc":"KDPGALDOL-RXN","metacyc":"KDPGALDOL-RXN","compounds":"2-dehydro-3-deoxy-6-phospho-D-gluconate => D-glyceraldehyde 3-phosphate + pyruvate"}
{"X":20181,"RHEA_ID":17091,"compounds":"D-glyceraldehyde 3-phosphate + pyruvate => 2-dehydro-3-deoxy-6-phospho-D-gluconate"}
{"X":20182,"RHEA_ID":37611,"compounds":"(9Z)-octadecenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":20183,"RHEA_ID":17093,"DIRECTION":"UN","MASTER_ID":17093,"ec":"4.6.1.13","compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol"}
{"X":20184,"RHEA_ID":17094,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) => 1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol"}
{"X":20185,"RHEA_ID":17095,"compounds":"1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)"}
{"X":20186,"RHEA_ID":17097,"DIRECTION":"UN","MASTER_ID":17097,"ec":"5.3.2.1","compounds":"3-phenylpyruvate = enol-phenylpyruvate"}
{"X":20187,"RHEA_ID":17098,"DIRECTION":"LR","MASTER_ID":17097,"ecocyc":"PHENYLPYRUVATE-TAUTOMERASE-RXN","metacyc":"PHENYLPYRUVATE-TAUTOMERASE-RXN","compounds":"3-phenylpyruvate => enol-phenylpyruvate"}
{"X":20188,"RHEA_ID":17099,"compounds":"enol-phenylpyruvate => 3-phenylpyruvate"}
{"X":20189,"RHEA_ID":27771,"DIRECTION":"LR","MASTER_ID":27770,"ecocyc":"2-OCTAPRENYL-6-OHPHENOL-METHY-RXN","metacyc":"2-OCTAPRENYL-6-OHPHENOL-METHY-RXN","compounds":"3-(all-trans-octaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine => 2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine"}
{"X":20190,"RHEA_ID":17101,"DIRECTION":"UN","MASTER_ID":17101,"ec":"3.1.1.28","compounds":"H2O + O-acyl-(R)-carnitine = (R)-carnitine + a fatty acid + H(+)"}
{"X":20191,"RHEA_ID":17102,"DIRECTION":"LR","MASTER_ID":17101,"metacyc":"ACYLCARNITINE-HYDROLASE-RXN","compounds":"H2O + O-acyl-(R)-carnitine => (R)-carnitine + a fatty acid + H(+)"}
{"X":20192,"RHEA_ID":17103,"compounds":"(R)-carnitine + a fatty acid + H(+) => H2O + O-acyl-(R)-carnitine"}
{"X":20193,"RHEA_ID":17105,"DIRECTION":"UN","MASTER_ID":17105,"ec":"2.1.1.197","compounds":"malonyl-[ACP] + S-adenosyl-L-methionine = malonyl-[ACP] methyl ester + S-adenosyl-L-homocysteine"}
{"X":20194,"RHEA_ID":17106,"DIRECTION":"LR","MASTER_ID":17105,"ecocyc":"RXN-11475","metacyc":"RXN-11475","compounds":"malonyl-[ACP] + S-adenosyl-L-methionine => malonyl-[ACP] methyl ester + S-adenosyl-L-homocysteine"}
{"X":20195,"RHEA_ID":17107,"compounds":"malonyl-[ACP] methyl ester + S-adenosyl-L-homocysteine => malonyl-[ACP] + S-adenosyl-L-methionine"}
{"X":20196,"RHEA_ID":27779,"DIRECTION":"LR","MASTER_ID":27778,"ecocyc":"3-OCTAPRENYL-4-OHBENZOATE-DECARBOX-RXN","metacyc":"3-OCTAPRENYL-4-OHBENZOATE-DECARBOX-RXN","compounds":"4-hydroxy-3-all-trans-octaprenylbenzoate + H(+) => 2-all-trans-octaprenylphenol + CO2"}
{"X":20197,"RHEA_ID":17109,"compounds":"FMNH2 + N-methylnicotinate + O2 = (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FMN + H(+)"}
{"X":20198,"RHEA_ID":17110,"compounds":"FMNH2 + N-methylnicotinate + O2 => (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FMN + H(+)"}
{"X":20199,"RHEA_ID":17111,"compounds":"(Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FMN + H(+) => FMNH2 + N-methylnicotinate + O2"}
{"X":20200,"RHEA_ID":17112,"compounds":"FMNH2 + N-methylnicotinate + O2 <=> (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FMN + H(+)"}
{"X":20201,"RHEA_ID":17113,"DIRECTION":"UN","MASTER_ID":17113,"ec":"3.1.4.13","compounds":"H2O + L-serine-phosphoethanolamine = H(+) + L-serine + phosphoethanolamine"}
{"X":20202,"RHEA_ID":17114,"DIRECTION":"LR","MASTER_ID":17113,"metacyc":"3.1.4.13-RXN","compounds":"H2O + L-serine-phosphoethanolamine => H(+) + L-serine + phosphoethanolamine"}
{"X":20203,"RHEA_ID":17115,"compounds":"H(+) + L-serine + phosphoethanolamine => H2O + L-serine-phosphoethanolamine"}
{"X":20204,"RHEA_ID":27787,"DIRECTION":"LR","MASTER_ID":27786,"ecocyc":"2OXOGLUTARATEDEH-RXN","metacyc":"2OXOGLUTARATEDEH-RXN","reactome":"R-HSA-71401.2","compounds":"2-oxoglutarate + CoA + NAD(+) => CO2 + NADH + succinyl-CoA"}
{"X":20205,"RHEA_ID":17117,"DIRECTION":"UN","MASTER_ID":17117,"ec":"6.3.4.12","compounds":"ATP + L-glutamate + methylamine = ADP + H(+) + N(5)-methyl-L-glutamine + phosphate"}
{"X":20206,"RHEA_ID":17118,"DIRECTION":"LR","MASTER_ID":17117,"metacyc":"GLUTAMATE--METHYLAMINE-LIGASE-RXN","compounds":"ATP + L-glutamate + methylamine => ADP + H(+) + N(5)-methyl-L-glutamine + phosphate"}
{"X":20207,"RHEA_ID":17119,"compounds":"ADP + H(+) + N(5)-methyl-L-glutamine + phosphate => ATP + L-glutamate + methylamine"}
{"X":20208,"RHEA_ID":27791,"DIRECTION":"LR","MASTER_ID":27790,"ecocyc":"2-OCTAPRENYLPHENOL-HYDROX-RXN","metacyc":"2-OCTAPRENYLPHENOL-HYDROX-RXN","compounds":"2-all-trans-octaprenylphenol + H(+) + NADPH + O2 => 3-(all-trans-octaprenyl)benzene-1,2-diol + H2O + NADP(+)"}
{"X":20209,"RHEA_ID":17121,"DIRECTION":"UN","MASTER_ID":17121,"ec":"2.1.3.8","metacyc":"LYSINE-CARBAMOYLTRANSFERASE-RXN","compounds":"carbamoyl phosphate + L-lysine = H(+) + L-homocitrulline + phosphate"}
{"X":20210,"RHEA_ID":17122,"compounds":"carbamoyl phosphate + L-lysine => H(+) + L-homocitrulline + phosphate"}
{"X":20211,"RHEA_ID":17123,"compounds":"H(+) + L-homocitrulline + phosphate => carbamoyl phosphate + L-lysine"}
{"X":20212,"RHEA_ID":27795,"compounds":"(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate => all-trans-heptaprenyl diphosphate + 4 diphosphate"}
{"X":20213,"RHEA_ID":17125,"compounds":"H2O + N-(4-carboxy-4-oxobutanoyl)-L-ethylglycylglycine = 2-oxoglutarate + N-(2-aminobutanoyl)glycine"}
{"X":20214,"RHEA_ID":17126,"compounds":"H2O + N-(4-carboxy-4-oxobutanoyl)-L-ethylglycylglycine => 2-oxoglutarate + N-(2-aminobutanoyl)glycine"}
{"X":20215,"RHEA_ID":17127,"compounds":"2-oxoglutarate + N-(2-aminobutanoyl)glycine => H2O + N-(4-carboxy-4-oxobutanoyl)-L-ethylglycylglycine"}
{"X":20216,"RHEA_ID":17129,"DIRECTION":"UN","MASTER_ID":17129,"ec":"6.3.5.3","compounds":"ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate"}
{"X":20217,"RHEA_ID":17130,"DIRECTION":"LR","MASTER_ID":17129,"ecocyc":"FGAMSYN-RXN","metacyc":"FGAMSYN-RXN","reactome":"R-HSA-73812.2","compounds":"ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide => 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate"}
{"X":20218,"RHEA_ID":17131,"compounds":"2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate => ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide"}
{"X":20219,"RHEA_ID":27803,"DIRECTION":"LR","MASTER_ID":27802,"metacyc":"RXN-9106","reactome":"R-HSA-2162253.2","compounds":"(2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate => all-trans-decaprenyl diphosphate + 7 diphosphate"}
{"X":20220,"RHEA_ID":17133,"DIRECTION":"UN","MASTER_ID":17133,"ec":"2.7.11.6","metacyc":"2.7.11.6-RXN","compounds":"ATP + L-seryl-[tyrosine-3-monooxygenase] = ADP + H(+) + O-phospho-L-seryl-[tyrosine-3-monooxygenase]"}
{"X":20221,"RHEA_ID":17134,"compounds":"ATP + L-seryl-[tyrosine-3-monooxygenase] => ADP + H(+) + O-phospho-L-seryl-[tyrosine-3-monooxygenase]"}
{"X":20222,"RHEA_ID":17135,"compounds":"ADP + H(+) + O-phospho-L-seryl-[tyrosine-3-monooxygenase] => ATP + L-seryl-[tyrosine-3-monooxygenase]"}
{"X":20223,"RHEA_ID":27807,"compounds":"acetoacetate + acetyl-CoA => acetate + acetoacetyl-CoA"}
{"X":20224,"RHEA_ID":17137,"DIRECTION":"UN","MASTER_ID":17137,"ec":"5.3.99.5","compounds":"prostaglandin H2 = thromboxane A2"}
{"X":20225,"RHEA_ID":17138,"DIRECTION":"LR","MASTER_ID":17137,"metacyc":"THROMBOXANE-A-SYNTHASE-RXN","reactome":"R-HSA-76500.1","compounds":"prostaglandin H2 => thromboxane A2"}
{"X":20226,"RHEA_ID":17139,"compounds":"thromboxane A2 => prostaglandin H2"}
{"X":20227,"RHEA_ID":27811,"DIRECTION":"LR","MASTER_ID":27810,"metacyc":"RXN-10481","compounds":"dimethylallyl diphosphate + 2 isopentenyl diphosphate => (2Z,6Z)-farnesyl diphosphate + 2 diphosphate"}
{"X":20228,"RHEA_ID":17141,"DIRECTION":"UN","MASTER_ID":17141,"ec":"2.6.1.35","compounds":"glycine + oxaloacetate = glyoxylate + L-aspartate"}
{"X":20229,"RHEA_ID":17142,"compounds":"glycine + oxaloacetate => glyoxylate + L-aspartate"}
{"X":20230,"RHEA_ID":17143,"compounds":"glyoxylate + L-aspartate => glycine + oxaloacetate"}
{"X":20231,"RHEA_ID":27815,"compounds":"acetate(in) => acetate(out)"}
{"X":20232,"RHEA_ID":17145,"DIRECTION":"UN","MASTER_ID":17145,"ec":"1.3.1.51","compounds":"2'-hydroxy-2,3-dihydrodaidzein + NADP(+) = 2'-hydroxydaidzein + 2 H(+) + NADPH"}
{"X":20233,"RHEA_ID":17146,"compounds":"2'-hydroxy-2,3-dihydrodaidzein + NADP(+) => 2'-hydroxydaidzein + 2 H(+) + NADPH"}
{"X":20234,"RHEA_ID":17147,"DIRECTION":"RL","MASTER_ID":17145,"metacyc":"RXN-4502","compounds":"2'-hydroxydaidzein + 2 H(+) + NADPH => 2'-hydroxy-2,3-dihydrodaidzein + NADP(+)"}
{"X":20235,"RHEA_ID":27819,"DIRECTION":"LR","MASTER_ID":27818,"metacyc":"RXN-12106","compounds":"2-dehydro-L-idonate + H(+) + NADH => L-idonate + NAD(+)"}
{"X":20236,"RHEA_ID":17149,"DIRECTION":"UN","MASTER_ID":17149,"ec":"1.14.14.1","compounds":"an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":20237,"RHEA_ID":17150,"DIRECTION":"LR","MASTER_ID":17149,"metacyc":"UNSPECIFIC-MONOOXYGENASE-RXN","compounds":"an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] => an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":20238,"RHEA_ID":17151,"compounds":"an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an organic molecule + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":20239,"RHEA_ID":17153,"DIRECTION":"UN","MASTER_ID":17153,"ec":"4.2.1.45","compounds":"CDP-D-glucose = CDP-4-dehydro-6-deoxy-D-glucose + H2O"}
{"X":20240,"RHEA_ID":17154,"DIRECTION":"LR","MASTER_ID":17153,"metacyc":"CDP-GLUCOSE-46-DEHYDRATASE-RXN","compounds":"CDP-D-glucose => CDP-4-dehydro-6-deoxy-D-glucose + H2O"}
{"X":20241,"RHEA_ID":17155,"compounds":"CDP-4-dehydro-6-deoxy-D-glucose + H2O => CDP-D-glucose"}
{"X":20242,"RHEA_ID":27827,"compounds":"hydrogen sulfide + O-succinyl-L-homoserine => L-homocysteine + succinate"}
{"X":20243,"RHEA_ID":17157,"DIRECTION":"UN","MASTER_ID":17157,"ec":"2.7.3.2","compounds":"ATP + creatine = ADP + H(+) + N-phosphocreatine"}
{"X":20244,"RHEA_ID":17158,"DIRECTION":"LR","MASTER_ID":17157,"reactome":"R-HSA-200318.2","compounds":"ATP + creatine => ADP + H(+) + N-phosphocreatine"}
{"X":20245,"RHEA_ID":17158,"DIRECTION":"LR","MASTER_ID":17157,"reactome":"R-HSA-200326.2","compounds":"ATP + creatine => ADP + H(+) + N-phosphocreatine"}
{"X":20246,"RHEA_ID":17159,"compounds":"ADP + H(+) + N-phosphocreatine => ATP + creatine"}
{"X":20247,"RHEA_ID":27832,"compounds":"beta-phellandrene + diphosphate => neryl diphosphate"}
{"X":20248,"RHEA_ID":17161,"DIRECTION":"UN","MASTER_ID":17161,"ec":"3.7.1.8","compounds":"2,6-dioxo-6-phenylhexa-3-enoate + H2O = 2-oxopent-4-enoate + benzoate + H(+)"}
{"X":20249,"RHEA_ID":17162,"DIRECTION":"LR","MASTER_ID":17161,"metacyc":"3.7.1.8-RXN","compounds":"2,6-dioxo-6-phenylhexa-3-enoate + H2O => 2-oxopent-4-enoate + benzoate + H(+)"}
{"X":20250,"RHEA_ID":17163,"compounds":"2-oxopent-4-enoate + benzoate + H(+) => 2,6-dioxo-6-phenylhexa-3-enoate + H2O"}
{"X":20251,"RHEA_ID":27836,"DIRECTION":"RL","MASTER_ID":27834,"ecocyc":"R601-RXN","metacyc":"R601-RXN","compounds":"a menaquinol + fumarate => a menaquinone + succinate"}
{"X":20252,"RHEA_ID":17165,"DIRECTION":"UN","MASTER_ID":17165,"ec":"2.7.7.32","metacyc":"2.7.7.32-RXN","compounds":"alpha-D-galactose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-D-galactose"}
{"X":20253,"RHEA_ID":17166,"compounds":"alpha-D-galactose 1-phosphate + dTTP + H(+) => diphosphate + dTDP-D-galactose"}
{"X":20254,"RHEA_ID":17167,"compounds":"diphosphate + dTDP-D-galactose => alpha-D-galactose 1-phosphate + dTTP + H(+)"}
{"X":20255,"RHEA_ID":27840,"compounds":"2'-aminobiphenyl-2,3-diol + NAD(+) => 9H-carbazole + H(+) + NADH + O2"}
{"X":20256,"RHEA_ID":17169,"DIRECTION":"UN","MASTER_ID":17169,"ec":"2.3.1.276","compounds":"acetyl-CoA + alpha-D-galactosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate"}
{"X":20257,"RHEA_ID":17170,"compounds":"acetyl-CoA + alpha-D-galactosamine 1-phosphate => CoA + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate"}
{"X":20258,"RHEA_ID":17171,"compounds":"CoA + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate => acetyl-CoA + alpha-D-galactosamine 1-phosphate"}
{"X":20259,"RHEA_ID":17172,"compounds":"acetyl-CoA + alpha-D-galactosamine 1-phosphate <=> CoA + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate"}
{"X":20260,"RHEA_ID":17173,"DIRECTION":"UN","MASTER_ID":17173,"ec":"3.5.1.78","compounds":"glutathionylspermidine + H2O = glutathione + spermidine"}
{"X":20261,"RHEA_ID":17174,"DIRECTION":"LR","MASTER_ID":17173,"ecocyc":"GSPAMID-RXN","compounds":"glutathionylspermidine + H2O => glutathione + spermidine"}
{"X":20262,"RHEA_ID":17175,"compounds":"glutathione + spermidine => glutathionylspermidine + H2O"}
{"X":20263,"RHEA_ID":27848,"compounds":"(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD(+) => (2E)-3-(3-hydroxyphenyl)prop-2-enoate + H(+) + NADH + O2"}
{"X":20264,"RHEA_ID":17177,"DIRECTION":"UN","MASTER_ID":17177,"ec":"2.3.1.137","compounds":"(R)-carnitine + octanoyl-CoA = CoA + O-octanoyl-(R)-carnitine"}
{"X":20265,"RHEA_ID":17178,"compounds":"(R)-carnitine + octanoyl-CoA => CoA + O-octanoyl-(R)-carnitine"}
{"X":20266,"RHEA_ID":17179,"compounds":"CoA + O-octanoyl-(R)-carnitine => (R)-carnitine + octanoyl-CoA"}
{"X":20267,"RHEA_ID":27852,"compounds":"CoA + H(+) + phenylacetylglycine => glycine + phenylacetyl-CoA"}
{"X":20268,"RHEA_ID":17181,"DIRECTION":"UN","MASTER_ID":17181,"ec":"1.14.14.3","compounds":"a long-chain fatty aldehyde + FMNH2 + O2 = a long-chain fatty acid + FMN + 2 H(+) + H2O + hnu"}
{"X":20269,"RHEA_ID":17182,"DIRECTION":"LR","MASTER_ID":17181,"metacyc":"ALKANAL-MONOOXYGENASE-FMN-LINKED-RXN","compounds":"a long-chain fatty aldehyde + FMNH2 + O2 => a long-chain fatty acid + FMN + 2 H(+) + H2O + hnu"}
{"X":20270,"RHEA_ID":17183,"compounds":"a long-chain fatty acid + FMN + 2 H(+) + H2O + hnu => a long-chain fatty aldehyde + FMNH2 + O2"}
{"X":20271,"RHEA_ID":17185,"DIRECTION":"UN","MASTER_ID":17185,"ec":"1.7.1.7","compounds":"IMP + NADP(+) + NH4(+) = GMP + 2 H(+) + NADPH"}
{"X":20272,"RHEA_ID":17186,"compounds":"IMP + NADP(+) + NH4(+) => GMP + 2 H(+) + NADPH"}
{"X":20273,"RHEA_ID":17187,"DIRECTION":"RL","MASTER_ID":17185,"ecocyc":"GMP-REDUCT-RXN","metacyc":"GMP-REDUCT-RXN","reactome":"R-HSA-514604.3","compounds":"GMP + 2 H(+) + NADPH => IMP + NADP(+) + NH4(+)"}
{"X":20274,"RHEA_ID":27860,"compounds":"3'-GMP + H(+) => 2',3'-cyclic GMP + H2O"}
{"X":20275,"RHEA_ID":17189,"compounds":"ATP + L-phenylalanine = diphosphate + H(+) + N-adenylyl-L-phenylalanine"}
{"X":20276,"RHEA_ID":17190,"compounds":"ATP + L-phenylalanine => diphosphate + H(+) + N-adenylyl-L-phenylalanine"}
{"X":20277,"RHEA_ID":17191,"compounds":"diphosphate + H(+) + N-adenylyl-L-phenylalanine => ATP + L-phenylalanine"}
{"X":20278,"RHEA_ID":17192,"compounds":"ATP + L-phenylalanine <=> diphosphate + H(+) + N-adenylyl-L-phenylalanine"}
{"X":20279,"RHEA_ID":17193,"DIRECTION":"UN","MASTER_ID":17193,"ec":"3.1.3.66","compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate"}
{"X":20280,"RHEA_ID":17194,"DIRECTION":"LR","MASTER_ID":17193,"metacyc":"3.1.3.66-RXN","compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate"}
{"X":20281,"RHEA_ID":17195,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + H2O"}
{"X":20282,"RHEA_ID":17197,"DIRECTION":"UN","MASTER_ID":17197,"ec":"1.2.3.13","compounds":"2 3-(4-hydroxyphenyl)pyruvate + O2 = 2 4-hydroxyphenylacetate + 2 CO2"}
{"X":20283,"RHEA_ID":17198,"DIRECTION":"LR","MASTER_ID":17197,"metacyc":"1.2.3.13-RXN","compounds":"2 3-(4-hydroxyphenyl)pyruvate + O2 => 2 4-hydroxyphenylacetate + 2 CO2"}
{"X":20284,"RHEA_ID":17199,"compounds":"2 4-hydroxyphenylacetate + 2 CO2 => 2 3-(4-hydroxyphenyl)pyruvate + O2"}
{"X":20285,"RHEA_ID":27872,"compounds":"(2E)-2-hydroxypenta-2,4-dienoate + anthranilate + H(+) => (2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O"}
{"X":20286,"RHEA_ID":17201,"DIRECTION":"UN","MASTER_ID":17201,"ec":"4.2.1.43","compounds":"2-dehydro-3-deoxy-L-arabinonate = 2,5-dioxopentanoate + H2O"}
{"X":20287,"RHEA_ID":17202,"DIRECTION":"LR","MASTER_ID":17201,"metacyc":"4.2.1.43-RXN","compounds":"2-dehydro-3-deoxy-L-arabinonate => 2,5-dioxopentanoate + H2O"}
{"X":20288,"RHEA_ID":17203,"compounds":"2,5-dioxopentanoate + H2O => 2-dehydro-3-deoxy-L-arabinonate"}
{"X":20289,"RHEA_ID":27876,"compounds":"pyruvate + salicylate => isochorismate"}
{"X":20290,"RHEA_ID":17205,"DIRECTION":"UN","MASTER_ID":17205,"ec":"2.8.2.27","compounds":"3'-phosphoadenylyl sulfate + quercetin 3-sulfate = adenosine 3',5'-bisphosphate + H(+) + quercetin 3,4'-bissulfate"}
{"X":20291,"RHEA_ID":17206,"DIRECTION":"LR","MASTER_ID":17205,"metacyc":"2.8.2.27-RXN","compounds":"3'-phosphoadenylyl sulfate + quercetin 3-sulfate => adenosine 3',5'-bisphosphate + H(+) + quercetin 3,4'-bissulfate"}
{"X":20292,"RHEA_ID":17207,"compounds":"adenosine 3',5'-bisphosphate + H(+) + quercetin 3,4'-bissulfate => 3'-phosphoadenylyl sulfate + quercetin 3-sulfate"}
{"X":20293,"RHEA_ID":27880,"compounds":"3'-UMP + H(+) => 2',3'-cyclic UMP + H2O"}
{"X":20294,"RHEA_ID":17209,"DIRECTION":"UN","MASTER_ID":17209,"ec":"3.5.2.18","compounds":"1,4,5,6-tetrahydro-6-oxonicotinate + 2 H2O = 2-formylglutarate + NH4(+)"}
{"X":20295,"RHEA_ID":17210,"DIRECTION":"LR","MASTER_ID":17209,"metacyc":"3.5.2.18-RXN","compounds":"1,4,5,6-tetrahydro-6-oxonicotinate + 2 H2O => 2-formylglutarate + NH4(+)"}
{"X":20296,"RHEA_ID":17211,"compounds":"2-formylglutarate + NH4(+) => 1,4,5,6-tetrahydro-6-oxonicotinate + 2 H2O"}
{"X":20297,"RHEA_ID":27884,"compounds":"3'-CMP + H(+) => 2',3'-cyclic CMP + H2O"}
{"X":20298,"RHEA_ID":17213,"DIRECTION":"UN","MASTER_ID":17213,"ec":"5.1.3.14","compounds":"UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-mannosamine"}
{"X":20299,"RHEA_ID":17214,"compounds":"UDP-N-acetyl-alpha-D-glucosamine => UDP-N-acetyl-alpha-D-mannosamine"}
{"X":20300,"RHEA_ID":17215,"compounds":"UDP-N-acetyl-alpha-D-mannosamine => UDP-N-acetyl-alpha-D-glucosamine"}
{"X":20301,"RHEA_ID":27888,"compounds":"3'-AMP + H(+) => 2',3'-cyclic AMP + H2O"}
{"X":20302,"RHEA_ID":17217,"DIRECTION":"UN","MASTER_ID":17217,"ec":"2.7.2.13","compounds":"ATP + L-glutamate = ADP + alpha-L-glutamyl phosphate"}
{"X":20303,"RHEA_ID":17218,"compounds":"ATP + L-glutamate => ADP + alpha-L-glutamyl phosphate"}
{"X":20304,"RHEA_ID":17219,"compounds":"ADP + alpha-L-glutamyl phosphate => ATP + L-glutamate"}
{"X":20305,"RHEA_ID":27892,"compounds":"phosphate + uridine => 3'-UMP + H2O"}
{"X":20306,"RHEA_ID":17221,"DIRECTION":"UN","MASTER_ID":17221,"ec":"4.2.1.46","compounds":"dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O"}
{"X":20307,"RHEA_ID":17222,"compounds":"dTDP-alpha-D-glucose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O"}
{"X":20308,"RHEA_ID":17223,"compounds":"dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O => dTDP-alpha-D-glucose"}
{"X":20309,"RHEA_ID":27896,"compounds":"cytidine + phosphate => 3'-CMP + H2O"}
{"X":20310,"RHEA_ID":17225,"DIRECTION":"UN","MASTER_ID":17225,"ec":"1.3.7.1","compounds":"1,4,5,6-tetrahydro-6-oxonicotinate + oxidized 2[4Fe-4S]-[ferredoxin] = 6-hydroxynicotinate + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]"}
{"X":20311,"RHEA_ID":17226,"compounds":"1,4,5,6-tetrahydro-6-oxonicotinate + oxidized 2[4Fe-4S]-[ferredoxin] => 6-hydroxynicotinate + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]"}
{"X":20312,"RHEA_ID":17227,"DIRECTION":"RL","MASTER_ID":17225,"metacyc":"6-HYDROXYNICOTINATE-REDUCTASE-RXN","compounds":"6-hydroxynicotinate + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] => 1,4,5,6-tetrahydro-6-oxonicotinate + oxidized 2[4Fe-4S]-[ferredoxin]"}
{"X":20313,"RHEA_ID":27900,"compounds":"adenosine + phosphate => 3'-AMP + H2O"}
{"X":20314,"RHEA_ID":17229,"DIRECTION":"UN","MASTER_ID":17229,"ec":"2.3.1.84","compounds":"acetyl-CoA + an aliphatic alcohol = an acetyl ester + CoA"}
{"X":20315,"RHEA_ID":17230,"compounds":"acetyl-CoA + an aliphatic alcohol => an acetyl ester + CoA"}
{"X":20316,"RHEA_ID":17231,"compounds":"an acetyl ester + CoA => acetyl-CoA + an aliphatic alcohol"}
{"X":20317,"RHEA_ID":27904,"compounds":"1,3,7-trimethylurate + ubiquinol-0 => caffeine + H2O + ubiquinone-0"}
{"X":20318,"RHEA_ID":17233,"DIRECTION":"UN","MASTER_ID":17233,"ec":"5.3.1.25","compounds":"L-fucose = L-fuculose"}
{"X":20319,"RHEA_ID":17234,"compounds":"L-fucose => L-fuculose"}
{"X":20320,"RHEA_ID":17235,"compounds":"L-fuculose => L-fucose"}
{"X":20321,"RHEA_ID":27908,"DIRECTION":"RL","MASTER_ID":27906,"metacyc":"RXN-11726","compounds":"(2E)-butenoyl-CoA + H(+) + NADPH => butanoyl-CoA + NADP(+)"}
{"X":20322,"RHEA_ID":17237,"DIRECTION":"UN","MASTER_ID":17237,"ec":"2.7.7.2","compounds":"ATP + FMN + H(+) = diphosphate + FAD"}
{"X":20323,"RHEA_ID":17238,"DIRECTION":"LR","MASTER_ID":17237,"ecocyc":"FADSYN-RXN","metacyc":"FADSYN-RXN","reactome":"R-HSA-196929.2","compounds":"ATP + FMN + H(+) => diphosphate + FAD"}
{"X":20324,"RHEA_ID":17239,"compounds":"diphosphate + FAD => ATP + FMN + H(+)"}
{"X":20325,"RHEA_ID":27912,"compounds":"2-dehydro-D-gluconate + H(+) + NADH => D-gluconate + NAD(+)"}
{"X":20326,"RHEA_ID":17241,"DIRECTION":"UN","MASTER_ID":17241,"ec":"3.1.1.43","compounds":"an alpha-amino acid ester + H2O = an alcohol + an alpha-amino acid + H(+)"}
{"X":20327,"RHEA_ID":17242,"DIRECTION":"LR","MASTER_ID":17241,"metacyc":"ALPHA-AMINO-ACID-ESTERASE-RXN","compounds":"an alpha-amino acid ester + H2O => an alcohol + an alpha-amino acid + H(+)"}
{"X":20328,"RHEA_ID":17243,"compounds":"an alcohol + an alpha-amino acid + H(+) => an alpha-amino acid ester + H2O"}
{"X":20329,"RHEA_ID":17245,"DIRECTION":"UN","MASTER_ID":17245,"ec":"1.10.3.5","compounds":"3-hydroxyanthranilate + O2 = 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2"}
{"X":20330,"RHEA_ID":17246,"DIRECTION":"LR","MASTER_ID":17245,"metacyc":"3-HYDROXYANTHRANILATE-OXIDASE-RXN","compounds":"3-hydroxyanthranilate + O2 => 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2"}
{"X":20331,"RHEA_ID":17247,"compounds":"6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2 => 3-hydroxyanthranilate + O2"}
{"X":20332,"RHEA_ID":27920,"compounds":"2 H(+) + NADPH + propanoate => H2O + NADP(+) + propanal"}
{"X":20333,"RHEA_ID":17249,"compounds":"2 Fe(2+) + 2 H2O + H2O2 = 6 H(+) + 2 iron(III) oxide-hydroxide"}
{"X":20334,"RHEA_ID":17250,"DIRECTION":"LR","MASTER_ID":17249,"ecocyc":"RXN-15293","metacyc":"RXN-15293","compounds":"2 Fe(2+) + 2 H2O + H2O2 => 6 H(+) + 2 iron(III) oxide-hydroxide"}
{"X":20335,"RHEA_ID":17251,"compounds":"6 H(+) + 2 iron(III) oxide-hydroxide => 2 Fe(2+) + 2 H2O + H2O2"}
{"X":20336,"RHEA_ID":17252,"compounds":"2 Fe(2+) + 2 H2O + H2O2 <=> 6 H(+) + 2 iron(III) oxide-hydroxide"}
{"X":20337,"RHEA_ID":17257,"DIRECTION":"UN","MASTER_ID":17257,"ec":"1.14.14.104","compounds":"O2 + reduced [NADPH--hemoprotein reductase] + vinorine = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + vomilenine"}
{"X":20338,"RHEA_ID":17258,"DIRECTION":"LR","MASTER_ID":17257,"metacyc":"1.14.13.75-RXN","compounds":"O2 + reduced [NADPH--hemoprotein reductase] + vinorine => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + vomilenine"}
{"X":20339,"RHEA_ID":17259,"compounds":"H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + vomilenine => O2 + reduced [NADPH--hemoprotein reductase] + vinorine"}
{"X":20340,"RHEA_ID":27928,"compounds":"UMP(out) => UMP(in)"}
{"X":20341,"RHEA_ID":17261,"DIRECTION":"UN","MASTER_ID":17261,"ec":"3.1.6.1","compounds":"a phenyl sulfate + H2O = a phenol + H(+) + sulfate"}
{"X":20342,"RHEA_ID":17262,"DIRECTION":"LR","MASTER_ID":17261,"ecocyc":"ARYLSULFAT-RXN","metacyc":"ARYLSULFAT-RXN","compounds":"a phenyl sulfate + H2O => a phenol + H(+) + sulfate"}
{"X":20343,"RHEA_ID":17263,"compounds":"a phenol + H(+) + sulfate => a phenyl sulfate + H2O"}
{"X":20344,"RHEA_ID":17265,"DIRECTION":"UN","MASTER_ID":17265,"ec":"5.3.3.7","compounds":"trans-aconitate = cis-aconitate"}
{"X":20345,"RHEA_ID":17266,"compounds":"trans-aconitate => cis-aconitate"}
{"X":20346,"RHEA_ID":17267,"compounds":"cis-aconitate => trans-aconitate"}
{"X":20347,"RHEA_ID":27936,"compounds":"glycine + glyoxylate => (3S)-3-hydroxy-D-aspartate"}
{"X":20348,"RHEA_ID":17269,"DIRECTION":"UN","MASTER_ID":17269,"ec":"2.1.1.101","compounds":"macrocin + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + tylosin"}
{"X":20349,"RHEA_ID":17270,"DIRECTION":"LR","MASTER_ID":17269,"metacyc":"MACROCIN-O-METHYLTRANSFERASE-RXN","compounds":"macrocin + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + tylosin"}
{"X":20350,"RHEA_ID":17271,"compounds":"H(+) + S-adenosyl-L-homocysteine + tylosin => macrocin + S-adenosyl-L-methionine"}
{"X":20351,"RHEA_ID":27940,"compounds":"glycine + glyoxylate => (3R)-3-hydroxy-D-aspartate"}
{"X":20352,"RHEA_ID":17273,"DIRECTION":"UN","MASTER_ID":17273,"ec":"1.2.1.53","compounds":"(4-hydroxyphenyl)acetaldehyde + H2O + NAD(+) = 4-hydroxyphenylacetate + 2 H(+) + NADH"}
{"X":20353,"RHEA_ID":17274,"DIRECTION":"LR","MASTER_ID":17273,"metacyc":"1.2.1.53-RXN","compounds":"(4-hydroxyphenyl)acetaldehyde + H2O + NAD(+) => 4-hydroxyphenylacetate + 2 H(+) + NADH"}
{"X":20354,"RHEA_ID":17275,"compounds":"4-hydroxyphenylacetate + 2 H(+) + NADH => (4-hydroxyphenyl)acetaldehyde + H2O + NAD(+)"}
{"X":20355,"RHEA_ID":27944,"compounds":"NH4(+) + oxaloacetate => (3R)-3-hydroxy-D-aspartate"}
{"X":20356,"RHEA_ID":17277,"DIRECTION":"UN","MASTER_ID":17277,"ec":"4.2.1.12","compounds":"6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O"}
{"X":20357,"RHEA_ID":17278,"DIRECTION":"LR","MASTER_ID":17277,"ecocyc":"PGLUCONDEHYDRAT-RXN","metacyc":"PGLUCONDEHYDRAT-RXN","compounds":"6-phospho-D-gluconate => 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O"}
{"X":20358,"RHEA_ID":17279,"compounds":"2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O => 6-phospho-D-gluconate"}
{"X":20359,"RHEA_ID":27948,"compounds":"3,4-dihydroxyphenylacetaldehyde + H2O2 + NH4(+) => dopamine + H2O + O2"}
{"X":20360,"RHEA_ID":17281,"DIRECTION":"UN","MASTER_ID":17281,"ec":"4.2.1.108","compounds":"(2S)-4-acetamido-2-aminobutanoate = H2O + L-ectoine"}
{"X":20361,"RHEA_ID":17282,"compounds":"(2S)-4-acetamido-2-aminobutanoate => H2O + L-ectoine"}
{"X":20362,"RHEA_ID":17283,"compounds":"H2O + L-ectoine => (2S)-4-acetamido-2-aminobutanoate"}
{"X":20363,"RHEA_ID":27951,"DIRECTION":"LR","MASTER_ID":27950,"reactome":"R-HSA-352158.1","compounds":"L-phenylalanine(in) => L-phenylalanine(out)"}
{"X":20364,"RHEA_ID":17285,"DIRECTION":"UN","MASTER_ID":17285,"ec":"2.4.1.336","compounds":"a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose = a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + H(+) + UDP"}
{"X":20365,"RHEA_ID":17286,"DIRECTION":"LR","MASTER_ID":17285,"metacyc":"2.4.1.157-RXN","compounds":"a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose => a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + H(+) + UDP"}
{"X":20366,"RHEA_ID":17287,"compounds":"a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + H(+) + UDP => a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose"}
{"X":20367,"RHEA_ID":27952,"compounds":"L-phenylalanine(out) => L-phenylalanine(in)"}
{"X":20368,"RHEA_ID":17289,"DIRECTION":"UN","MASTER_ID":17289,"ec":"3.1.3.46","compounds":"beta-D-fructose 2,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate"}
{"X":20369,"RHEA_ID":17290,"DIRECTION":"LR","MASTER_ID":17289,"metacyc":"3.1.3.46-RXN","compounds":"beta-D-fructose 2,6-bisphosphate + H2O => beta-D-fructose 6-phosphate + phosphate"}
{"X":20370,"RHEA_ID":17291,"compounds":"beta-D-fructose 6-phosphate + phosphate => beta-D-fructose 2,6-bisphosphate + H2O"}
{"X":20371,"RHEA_ID":27956,"compounds":"diphosphate + presilphiperfolan-8beta-ol => (2E,6E)-farnesyl diphosphate + H2O"}
{"X":20372,"RHEA_ID":17293,"DIRECTION":"UN","MASTER_ID":17293,"ec":"1.14.13.83","compounds":"2 H(+) + NADH + O2 + precorrin-3A = H2O + NAD(+) + precorrin-3B"}
{"X":20373,"RHEA_ID":17294,"DIRECTION":"LR","MASTER_ID":17293,"metacyc":"R321-RXN","compounds":"2 H(+) + NADH + O2 + precorrin-3A => H2O + NAD(+) + precorrin-3B"}
{"X":20374,"RHEA_ID":17295,"compounds":"H2O + NAD(+) + precorrin-3B => 2 H(+) + NADH + O2 + precorrin-3A"}
{"X":20375,"RHEA_ID":27960,"compounds":"cytosine + D-ribose => cytidine + H2O"}
{"X":20376,"RHEA_ID":17297,"DIRECTION":"UN","MASTER_ID":17297,"ec":"1.2.7.3","compounds":"2-oxoglutarate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] + succinyl-CoA"}
{"X":20377,"RHEA_ID":17298,"compounds":"2-oxoglutarate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] => CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] + succinyl-CoA"}
{"X":20378,"RHEA_ID":17299,"compounds":"CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] + succinyl-CoA => 2-oxoglutarate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":20379,"RHEA_ID":27964,"compounds":"H(+) + pyrroloquinoline quinol + scyllo-inosose => myo-inositol + pyrroloquinoline quinone"}
{"X":20380,"RHEA_ID":17301,"DIRECTION":"UN","MASTER_ID":17301,"ec":"2.7.11.4","compounds":"[3-methyl-2-oxobutanoate dehydrogenase]-L-serine + ATP = [3-methyl-2-oxobutanoate dehydrogenase]-O-phospho-L-serine + ADP + H(+)"}
{"X":20381,"RHEA_ID":17302,"compounds":"[3-methyl-2-oxobutanoate dehydrogenase]-L-serine + ATP => [3-methyl-2-oxobutanoate dehydrogenase]-O-phospho-L-serine + ADP + H(+)"}
{"X":20382,"RHEA_ID":17303,"compounds":"[3-methyl-2-oxobutanoate dehydrogenase]-O-phospho-L-serine + ADP + H(+) => [3-methyl-2-oxobutanoate dehydrogenase]-L-serine + ATP"}
{"X":20383,"RHEA_ID":27968,"compounds":"6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate => 7,8-dihydroneopterin 3'-triphosphate + H2O"}
{"X":20384,"RHEA_ID":17305,"DIRECTION":"UN","MASTER_ID":17305,"ec":"3.5.3.18","compounds":"H2O + N(omega),N(omega)-dimethyl-L-arginine = dimethylamine + L-citrulline"}
{"X":20385,"RHEA_ID":17306,"compounds":"H2O + N(omega),N(omega)-dimethyl-L-arginine => dimethylamine + L-citrulline"}
{"X":20386,"RHEA_ID":17307,"compounds":"dimethylamine + L-citrulline => H2O + N(omega),N(omega)-dimethyl-L-arginine"}
{"X":20387,"RHEA_ID":27972,"compounds":"alpha-D-glucose + beta-maltose => alpha-maltotriose + H2O"}
{"X":20388,"RHEA_ID":17309,"DIRECTION":"UN","MASTER_ID":17309,"ec":"3.1.1.2","compounds":"a phenyl acetate + H2O = a phenol + acetate + H(+)"}
{"X":20389,"RHEA_ID":17310,"DIRECTION":"LR","MASTER_ID":17309,"metacyc":"ARYLESTERASE-RXN","compounds":"a phenyl acetate + H2O => a phenol + acetate + H(+)"}
{"X":20390,"RHEA_ID":17311,"compounds":"a phenol + acetate + H(+) => a phenyl acetate + H2O"}
{"X":20391,"RHEA_ID":17313,"DIRECTION":"UN","MASTER_ID":17313,"ec":"6.1.1.21","compounds":"ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)"}
{"X":20392,"RHEA_ID":17314,"DIRECTION":"LR","MASTER_ID":17313,"ecocyc":"HISTIDINE--TRNA-LIGASE-RXN","metacyc":"HISTIDINE--TRNA-LIGASE-RXN","compounds":"ATP + L-histidine + tRNA(His) => AMP + diphosphate + H(+) + L-histidyl-tRNA(His)"}
{"X":20393,"RHEA_ID":17315,"compounds":"AMP + diphosphate + H(+) + L-histidyl-tRNA(His) => ATP + L-histidine + tRNA(His)"}
{"X":20394,"RHEA_ID":27980,"compounds":"alpha-D-mannose 1-phosphate + GMP + 2 H(+) => GDP-alpha-D-mannose + H2O"}
{"X":20395,"RHEA_ID":17317,"DIRECTION":"UN","MASTER_ID":17317,"ec":"2.5.1.62","compounds":"chlorophyllide a + H(+) + phytyl diphosphate = chlorophyll a + diphosphate"}
{"X":20396,"RHEA_ID":17318,"compounds":"chlorophyllide a + H(+) + phytyl diphosphate => chlorophyll a + diphosphate"}
{"X":20397,"RHEA_ID":17319,"compounds":"chlorophyll a + diphosphate => chlorophyllide a + H(+) + phytyl diphosphate"}
{"X":20398,"RHEA_ID":27984,"compounds":"7-cyano-7-deazaguanine + ADP + H(+) + H2O + phosphate => 7-carboxy-7-deazaguanine + ATP + NH4(+)"}
{"X":20399,"RHEA_ID":17321,"DIRECTION":"UN","MASTER_ID":17321,"ec":"2.1.1.106","compounds":"L-tryptophan + S-adenosyl-L-methionine = 2-methyl-L-tryptophan + H(+) + S-adenosyl-L-homocysteine"}
{"X":20400,"RHEA_ID":17322,"DIRECTION":"LR","MASTER_ID":17321,"metacyc":"RXN-16751","compounds":"L-tryptophan + S-adenosyl-L-methionine => 2-methyl-L-tryptophan + H(+) + S-adenosyl-L-homocysteine"}
{"X":20401,"RHEA_ID":17323,"compounds":"2-methyl-L-tryptophan + H(+) + S-adenosyl-L-homocysteine => L-tryptophan + S-adenosyl-L-methionine"}
{"X":20402,"RHEA_ID":27988,"DIRECTION":"RL","MASTER_ID":27986,"ecocyc":"RXN0-4281","metacyc":"RXN0-4281","compounds":"H(+) + methylglyoxal + NADPH => hydroxyacetone + NADP(+)"}
{"X":20403,"RHEA_ID":17325,"DIRECTION":"UN","MASTER_ID":17325,"ec":"2.3.1.117","compounds":"(S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA = (S)-2-succinylamino-6-oxoheptanedioate + CoA"}
{"X":20404,"RHEA_ID":17326,"compounds":"(S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA => (S)-2-succinylamino-6-oxoheptanedioate + CoA"}
{"X":20405,"RHEA_ID":17327,"compounds":"(S)-2-succinylamino-6-oxoheptanedioate + CoA => (S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA"}
{"X":20406,"RHEA_ID":27992,"compounds":"1-deoxy-D-xylulose 5-phosphate + ADP + H(+) => 1-deoxy-D-xylulose + ATP"}
{"X":20407,"RHEA_ID":17329,"DIRECTION":"UN","MASTER_ID":17329,"ec":"1.1.1.198","compounds":"(1R,2S,4R)-borneol + NAD(+) = (1R,4R)-camphor + H(+) + NADH"}
{"X":20408,"RHEA_ID":17330,"compounds":"(1R,2S,4R)-borneol + NAD(+) => (1R,4R)-camphor + H(+) + NADH"}
{"X":20409,"RHEA_ID":17331,"compounds":"(1R,4R)-camphor + H(+) + NADH => (1R,2S,4R)-borneol + NAD(+)"}
{"X":20410,"RHEA_ID":27996,"compounds":"D-ribose + xanthine => H2O + xanthosine"}
{"X":20411,"RHEA_ID":17333,"DIRECTION":"UN","MASTER_ID":17333,"ec":"2.5.1.50","compounds":"O-acetyl-L-serine + zeatin = acetate + H(+) + L-lupinate"}
{"X":20412,"RHEA_ID":17334,"DIRECTION":"LR","MASTER_ID":17333,"metacyc":"BETA-9-CYTOKININ-ALANINE-SYNTHASE-RXN","compounds":"O-acetyl-L-serine + zeatin => acetate + H(+) + L-lupinate"}
{"X":20413,"RHEA_ID":17335,"compounds":"acetate + H(+) + L-lupinate => O-acetyl-L-serine + zeatin"}
{"X":20414,"RHEA_ID":28000,"compounds":"H(+) + phosphate + thiamine phosphate => H2O + thiamine diphosphate"}
{"X":20415,"RHEA_ID":17337,"DIRECTION":"UN","MASTER_ID":17337,"ec":"1.13.11.2","compounds":"catechol + O2 = (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H(+)"}
{"X":20416,"RHEA_ID":17338,"DIRECTION":"LR","MASTER_ID":17337,"metacyc":"CATECHOL-23-DIOXYGENASE-RXN","compounds":"catechol + O2 => (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H(+)"}
{"X":20417,"RHEA_ID":17339,"compounds":"(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H(+) => catechol + O2"}
{"X":20418,"RHEA_ID":28004,"compounds":"D-glyceraldehyde 3-phosphate + dihydroxyacetone => beta-D-fructose 6-phosphate"}
{"X":20419,"RHEA_ID":17341,"DIRECTION":"UN","MASTER_ID":17341,"ec":"1.1.1.101","compounds":"1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) = 1-hexadecanoylglycerone 3-phosphate + H(+) + NADPH"}
{"X":20420,"RHEA_ID":17342,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) => 1-hexadecanoylglycerone 3-phosphate + H(+) + NADPH"}
{"X":20421,"RHEA_ID":17343,"compounds":"1-hexadecanoylglycerone 3-phosphate + H(+) + NADPH => 1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+)"}
{"X":20422,"RHEA_ID":28008,"compounds":"formaldehyde + H2O2 + L-tryptophan => H2O + N(alpha)-methyl-L-tryptophan + O2"}
{"X":20423,"RHEA_ID":17345,"DIRECTION":"UN","MASTER_ID":17345,"ec":"3.1.2.17","compounds":"(S)-methylmalonyl-CoA + H2O = CoA + H(+) + methylmalonate"}
{"X":20424,"RHEA_ID":17346,"DIRECTION":"LR","MASTER_ID":17345,"metacyc":"S-METHYLMALONYL-COA-HYDROLASE-RXN","compounds":"(S)-methylmalonyl-CoA + H2O => CoA + H(+) + methylmalonate"}
{"X":20425,"RHEA_ID":17347,"compounds":"CoA + H(+) + methylmalonate => (S)-methylmalonyl-CoA + H2O"}
{"X":20426,"RHEA_ID":28012,"compounds":"propanoate + succinyl-CoA => propanoyl-CoA + succinate"}
{"X":20427,"RHEA_ID":17349,"DIRECTION":"UN","MASTER_ID":17349,"ec":"2.5.1.146","compounds":"(2E)-geranyl diphosphate + 3-[(Z)-2-isocyanoethenyl]-1H-indole = 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole + diphosphate"}
{"X":20428,"RHEA_ID":17350,"DIRECTION":"LR","MASTER_ID":17349,"metacyc":"RXN-19272","compounds":"(2E)-geranyl diphosphate + 3-[(Z)-2-isocyanoethenyl]-1H-indole => 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole + diphosphate"}
{"X":20429,"RHEA_ID":17351,"compounds":"3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole + diphosphate => (2E)-geranyl diphosphate + 3-[(Z)-2-isocyanoethenyl]-1H-indole"}
{"X":20430,"RHEA_ID":28016,"compounds":"methyl thiocyanate + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + thiocyanate"}
{"X":20431,"RHEA_ID":17357,"DIRECTION":"UN","MASTER_ID":17357,"ec":"1.8.3.2","compounds":"O2 + 2 R'C(R)SH = H2O2 + R'C(R)S-S(R)CR'"}
{"X":20432,"RHEA_ID":17358,"compounds":"O2 + 2 R'C(R)SH => H2O2 + R'C(R)S-S(R)CR'"}
{"X":20433,"RHEA_ID":17359,"compounds":"H2O2 + R'C(R)S-S(R)CR' => O2 + 2 R'C(R)SH"}
{"X":20434,"RHEA_ID":17360,"compounds":"O2 + 2 R'C(R)SH <=> H2O2 + R'C(R)S-S(R)CR'"}
{"X":20435,"RHEA_ID":17361,"DIRECTION":"UN","MASTER_ID":17361,"ec":"3.5.1.95","compounds":"3-oxo-3-ureidopropanoate + H2O = H(+) + malonate + urea"}
{"X":20436,"RHEA_ID":17362,"DIRECTION":"LR","MASTER_ID":17361,"metacyc":"3.5.1.95-RXN","compounds":"3-oxo-3-ureidopropanoate + H2O => H(+) + malonate + urea"}
{"X":20437,"RHEA_ID":17363,"compounds":"H(+) + malonate + urea => 3-oxo-3-ureidopropanoate + H2O"}
{"X":20438,"RHEA_ID":28024,"compounds":"AMP + diphosphate + octanoyl-[ACP] => ATP + holo-[ACP] + octanoate"}
{"X":20439,"RHEA_ID":17365,"DIRECTION":"UN","MASTER_ID":17365,"ec":"7.2.2.5","compounds":"ATP + H2O + Mn(2+)(out) = ADP + H(+) + Mn(2+)(in) + phosphate"}
{"X":20440,"RHEA_ID":17366,"DIRECTION":"LR","MASTER_ID":17365,"metacyc":"3.6.3.35-RXN","compounds":"ATP + H2O + Mn(2+)(out) => ADP + H(+) + Mn(2+)(in) + phosphate"}
{"X":20441,"RHEA_ID":17367,"compounds":"ADP + H(+) + Mn(2+)(in) + phosphate => ATP + H2O + Mn(2+)(out)"}
{"X":20442,"RHEA_ID":17368,"compounds":"ATP + H2O + Mn(2+)(out) <=> ADP + H(+) + Mn(2+)(in) + phosphate"}
{"X":20443,"RHEA_ID":17369,"DIRECTION":"UN","MASTER_ID":17369,"ec":"3.2.1.128","compounds":"glycyrrhizin + H2O = 2-(beta-D-glucuronosyl)-D-glucuronate + glycyrrhetinate"}
{"X":20444,"RHEA_ID":17370,"DIRECTION":"LR","MASTER_ID":17369,"metacyc":"GLYCYRRHIZINATE-BETA-GLUCURONIDASE-RXN","compounds":"glycyrrhizin + H2O => 2-(beta-D-glucuronosyl)-D-glucuronate + glycyrrhetinate"}
{"X":20445,"RHEA_ID":17371,"compounds":"2-(beta-D-glucuronosyl)-D-glucuronate + glycyrrhetinate => glycyrrhizin + H2O"}
{"X":20446,"RHEA_ID":28032,"DIRECTION":"RL","MASTER_ID":28030,"ecocyc":"GDPREDUCT-RXN","metacyc":"GDPREDUCT-RXN","compounds":"[thioredoxin]-dithiol + GDP => [thioredoxin]-disulfide + dGDP + H2O"}
{"X":20447,"RHEA_ID":17373,"DIRECTION":"UN","MASTER_ID":17373,"ec":"5.3.99.8","compounds":"all-trans-antheraxanthin = all-trans-capsanthin"}
{"X":20448,"RHEA_ID":17374,"DIRECTION":"LR","MASTER_ID":17373,"metacyc":"RXN-7947","compounds":"all-trans-antheraxanthin => all-trans-capsanthin"}
{"X":20449,"RHEA_ID":17375,"compounds":"all-trans-capsanthin => all-trans-antheraxanthin"}
{"X":20450,"RHEA_ID":28036,"DIRECTION":"RL","MASTER_ID":28034,"metacyc":"ADPREDUCT-RXN","compounds":"[thioredoxin]-dithiol + ADP => [thioredoxin]-disulfide + dADP + H2O"}
{"X":20451,"RHEA_ID":17377,"DIRECTION":"UN","MASTER_ID":17377,"ec":"2.4.1.109","compounds":"dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + dolichyl phosphate + H(+)"}
{"X":20452,"RHEA_ID":17378,"DIRECTION":"LR","MASTER_ID":17377,"metacyc":"2.4.1.109-RXN","compounds":"dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] => 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + dolichyl phosphate + H(+)"}
{"X":20453,"RHEA_ID":17379,"compounds":"3-O-(alpha-D-mannosyl)-L-seryl-[protein] + dolichyl phosphate + H(+) => dolichyl beta-D-mannosyl phosphate + L-seryl-[protein]"}
{"X":20454,"RHEA_ID":17381,"DIRECTION":"UN","MASTER_ID":17381,"ec":"5.2.1.5","metacyc":"LINOLEATE-ISOMERASE-RXN","compounds":"(9Z,12Z)-octadecadienoate = (9Z,11E)-octadecadienoate"}
{"X":20455,"RHEA_ID":17382,"compounds":"(9Z,12Z)-octadecadienoate => (9Z,11E)-octadecadienoate"}
{"X":20456,"RHEA_ID":17383,"compounds":"(9Z,11E)-octadecadienoate => (9Z,12Z)-octadecadienoate"}
{"X":20457,"RHEA_ID":28044,"compounds":"acetyl-CoA + CO2 + NADH => CoA + NAD(+) + pyruvate"}
{"X":20458,"RHEA_ID":17385,"DIRECTION":"UN","MASTER_ID":17385,"ec":"1.8.1.3","compounds":"H2O + hypotaurine + NAD(+) = H(+) + NADH + taurine"}
{"X":20459,"RHEA_ID":17386,"DIRECTION":"LR","MASTER_ID":17385,"metacyc":"HYPOTAURINE-DEHYDROGENASE-RXN","reactome":"R-HSA-1655453.3","compounds":"H2O + hypotaurine + NAD(+) => H(+) + NADH + taurine"}
{"X":20460,"RHEA_ID":17387,"compounds":"H(+) + NADH + taurine => H2O + hypotaurine + NAD(+)"}
{"X":20461,"RHEA_ID":28048,"compounds":"CoA + propanoyl phosphate => phosphate + propanoyl-CoA"}
{"X":20462,"RHEA_ID":17389,"DIRECTION":"UN","MASTER_ID":17389,"ec":"1.1.1.250","compounds":"D-arabinitol + NAD(+) = D-ribulose + H(+) + NADH"}
{"X":20463,"RHEA_ID":17390,"compounds":"D-arabinitol + NAD(+) => D-ribulose + H(+) + NADH"}
{"X":20464,"RHEA_ID":17391,"compounds":"D-ribulose + H(+) + NADH => D-arabinitol + NAD(+)"}
{"X":20465,"RHEA_ID":28052,"compounds":"NAD(+) + phosphate => H2O + NADP(+)"}
{"X":20466,"RHEA_ID":17393,"DIRECTION":"UN","MASTER_ID":17393,"ec":"5.2.1.4","compounds":"3-maleylpyruvate = 3-fumarylpyruvate"}
{"X":20467,"RHEA_ID":17394,"DIRECTION":"LR","MASTER_ID":17393,"metacyc":"MALEYLPYRUVATE-ISOMERASE-RXN","compounds":"3-maleylpyruvate => 3-fumarylpyruvate"}
{"X":20468,"RHEA_ID":17395,"compounds":"3-fumarylpyruvate => 3-maleylpyruvate"}
{"X":20469,"RHEA_ID":28056,"compounds":"formate + propanoyl-CoA => 2-oxobutanoate + CoA"}
{"X":20470,"RHEA_ID":17397,"DIRECTION":"UN","MASTER_ID":17397,"ec":"1.1.1.100","compounds":"a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH"}
{"X":20471,"RHEA_ID":17398,"compounds":"a (3R)-hydroxyacyl-[ACP] + NADP(+) => a 3-oxoacyl-[ACP] + H(+) + NADPH"}
{"X":20472,"RHEA_ID":17399,"DIRECTION":"RL","MASTER_ID":17397,"ecocyc":"3-OXOACYL-ACP-REDUCT-RXN","metacyc":"3-OXOACYL-ACP-REDUCT-RXN","compounds":"a 3-oxoacyl-[ACP] + H(+) + NADPH => a (3R)-hydroxyacyl-[ACP] + NADP(+)"}
{"X":20473,"RHEA_ID":17401,"DIRECTION":"UN","MASTER_ID":17401,"ec":"4.2.1.83","compounds":"2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = 4-carboxy-2-hydroxy-cis,cis-muconate + H2O"}
{"X":20474,"RHEA_ID":17402,"compounds":"2-hydroxy-4-oxobutane-1,2,4-tricarboxylate => 4-carboxy-2-hydroxy-cis,cis-muconate + H2O"}
{"X":20475,"RHEA_ID":17403,"compounds":"4-carboxy-2-hydroxy-cis,cis-muconate + H2O => 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate"}
{"X":20476,"RHEA_ID":17405,"DIRECTION":"UN","MASTER_ID":17405,"ec":"2.1.1.105","compounds":"N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine = H(+) + N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine"}
{"X":20477,"RHEA_ID":17406,"DIRECTION":"LR","MASTER_ID":17405,"metacyc":"2.1.1.105-RXN","compounds":"N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine => H(+) + N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine"}
{"X":20478,"RHEA_ID":17407,"compounds":"H(+) + N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine => N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine"}
{"X":20479,"RHEA_ID":28067,"DIRECTION":"LR","MASTER_ID":28066,"ecocyc":"KDOTRANS-RXN","metacyc":"KDOTRANS-RXN","compounds":"CMP-3-deoxy-beta-D-manno-octulosonate + lipid IVA (E. coli) => alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)"}
{"X":20480,"RHEA_ID":17409,"DIRECTION":"UN","MASTER_ID":17409,"ec":"2.1.1.140","compounds":"(S)-coclaurine + S-adenosyl-L-methionine = (S)-N-methylcoclaurine + H(+) + S-adenosyl-L-homocysteine"}
{"X":20481,"RHEA_ID":17410,"DIRECTION":"LR","MASTER_ID":17409,"metacyc":"2.1.1.140-RXN","compounds":"(S)-coclaurine + S-adenosyl-L-methionine => (S)-N-methylcoclaurine + H(+) + S-adenosyl-L-homocysteine"}
{"X":20482,"RHEA_ID":17411,"compounds":"(S)-N-methylcoclaurine + H(+) + S-adenosyl-L-homocysteine => (S)-coclaurine + S-adenosyl-L-methionine"}
{"X":20483,"RHEA_ID":28071,"DIRECTION":"LR","MASTER_ID":28070,"ecocyc":"HEMEOSYN-RXN","metacyc":"HEMEOSYN-RXN","compounds":"(2E,6E)-farnesyl diphosphate + H2O + heme b => diphosphate + Fe(II)-heme o"}
{"X":20484,"RHEA_ID":17413,"DIRECTION":"UN","MASTER_ID":17413,"ec":"2.4.1.150","compounds":"a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-beta-D-glucosaminyl-(1->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP"}
{"X":20485,"RHEA_ID":17414,"compounds":"a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine => an N-acetyl-beta-D-glucosaminyl-(1->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP"}
{"X":20486,"RHEA_ID":17415,"compounds":"an N-acetyl-beta-D-glucosaminyl-(1->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":20487,"RHEA_ID":28075,"DIRECTION":"LR","MASTER_ID":28074,"metacyc":"RXN-11727","compounds":"(2R)-3-sulfopropanediol + H2O + 2 NAD(+) => (R)-3-sulfolactate + 3 H(+) + 2 NADH"}
{"X":20488,"RHEA_ID":17417,"DIRECTION":"UN","MASTER_ID":17417,"ec":"2.7.1.59","compounds":"ATP + N-acetyl-D-glucosamine = ADP + H(+) + N-acetyl-D-glucosamine 6-phosphate"}
{"X":20489,"RHEA_ID":17418,"DIRECTION":"LR","MASTER_ID":17417,"ecocyc":"N-ACETYLGLUCOSAMINE-KINASE-RXN","metacyc":"N-ACETYLGLUCOSAMINE-KINASE-RXN","compounds":"ATP + N-acetyl-D-glucosamine => ADP + H(+) + N-acetyl-D-glucosamine 6-phosphate"}
{"X":20490,"RHEA_ID":17419,"compounds":"ADP + H(+) + N-acetyl-D-glucosamine 6-phosphate => ATP + N-acetyl-D-glucosamine"}
{"X":20491,"RHEA_ID":28079,"compounds":"2-hydroxyethylphosphonate + NAD(+) => H(+) + NADH + phosphonoacetaldehyde"}
{"X":20492,"RHEA_ID":17425,"DIRECTION":"UN","MASTER_ID":17425,"ec":"1.2.1.51","compounds":"CoA + NADP(+) + pyruvate = acetyl-CoA + CO2 + NADPH"}
{"X":20493,"RHEA_ID":17426,"compounds":"CoA + NADP(+) + pyruvate => acetyl-CoA + CO2 + NADPH"}
{"X":20494,"RHEA_ID":17427,"compounds":"acetyl-CoA + CO2 + NADPH => CoA + NADP(+) + pyruvate"}
{"X":20495,"RHEA_ID":28083,"compounds":"(2S)-ethylmalonyl-CoA + NADP(+) => (2E)-butenoyl-CoA + CO2 + NADPH"}
{"X":20496,"RHEA_ID":17429,"DIRECTION":"UN","MASTER_ID":17429,"ec":"1.1.1.226","metacyc":"1.1.1.226-RXN","compounds":"NAD(+) + trans-4-hydroxycyclohexanecarboxylate = 4-oxocyclohexanecarboxylate + H(+) + NADH"}
{"X":20497,"RHEA_ID":17430,"compounds":"NAD(+) + trans-4-hydroxycyclohexanecarboxylate => 4-oxocyclohexanecarboxylate + H(+) + NADH"}
{"X":20498,"RHEA_ID":17431,"compounds":"4-oxocyclohexanecarboxylate + H(+) + NADH => NAD(+) + trans-4-hydroxycyclohexanecarboxylate"}
{"X":20499,"RHEA_ID":28087,"compounds":"2 H2O2 + Reactive Blue 5 => 2,2'-disulfonyl azobenzene + 3-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]benzenesulfonate + 2 H(+) + 2 H2O + phthalate"}
{"X":20500,"RHEA_ID":17433,"DIRECTION":"UN","MASTER_ID":17433,"ec":"1.1.99.1","compounds":"A + choline = AH2 + betaine aldehyde"}
{"X":20501,"RHEA_ID":17434,"DIRECTION":"LR","MASTER_ID":17433,"ecocyc":"CHD-RXN","compounds":"A + choline => AH2 + betaine aldehyde"}
{"X":20502,"RHEA_ID":17435,"compounds":"AH2 + betaine aldehyde => A + choline"}
{"X":20503,"RHEA_ID":28091,"DIRECTION":"LR","MASTER_ID":28090,"ecocyc":"GLCNACPTRANS-RXN","metacyc":"GLCNACPTRANS-RXN","compounds":"di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine => N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UMP"}
{"X":20504,"RHEA_ID":17437,"DIRECTION":"UN","MASTER_ID":17437,"ec":"5.5.1.11","compounds":"2,4-dichloro-5-oxo-2,5-dihydro-2-furylacetate = (2E,4E)-2,4-dichloromuconate + H(+)"}
{"X":20505,"RHEA_ID":17438,"compounds":"2,4-dichloro-5-oxo-2,5-dihydro-2-furylacetate => (2E,4E)-2,4-dichloromuconate + H(+)"}
{"X":20506,"RHEA_ID":17439,"DIRECTION":"RL","MASTER_ID":17437,"metacyc":"DICHLOROMUCONATE-CYCLOISOMERASE-RXN","compounds":"(2E,4E)-2,4-dichloromuconate + H(+) => 2,4-dichloro-5-oxo-2,5-dihydro-2-furylacetate"}
{"X":20507,"RHEA_ID":28095,"DIRECTION":"LR","MASTER_ID":28094,"ecocyc":"UNDECAPRENYL-DIPHOSPHATASE-RXN","metacyc":"UNDECAPRENYL-DIPHOSPHATASE-RXN","compounds":"di-trans,octa-cis-undecaprenyl diphosphate + H2O => di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate"}
{"X":20508,"RHEA_ID":17441,"DIRECTION":"UN","MASTER_ID":17441,"ec":"2.6.1.3","compounds":"2-oxoglutarate + L-cysteine = 3-mercaptopyruvate + L-glutamate"}
{"X":20509,"RHEA_ID":17442,"DIRECTION":"LR","MASTER_ID":17441,"ecocyc":"CYSTEINE-AMINOTRANSFERASE-RXN","reactome":"R-HSA-9012597.1","compounds":"2-oxoglutarate + L-cysteine => 3-mercaptopyruvate + L-glutamate"}
{"X":20510,"RHEA_ID":17443,"compounds":"3-mercaptopyruvate + L-glutamate => 2-oxoglutarate + L-cysteine"}
{"X":20511,"RHEA_ID":28099,"DIRECTION":"LR","MASTER_ID":28098,"ecocyc":"GDPPYPHOSKIN-RXN","metacyc":"GDPPYPHOSKIN-RXN","compounds":"ATP + GDP => AMP + guanosine 3',5'-bis(diphosphate)"}
{"X":20512,"RHEA_ID":17445,"DIRECTION":"UN","MASTER_ID":17445,"ec":"1.12.7.2","compounds":"H2 + 2 oxidized [2Fe-2S]-[ferredoxin] = 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":20513,"RHEA_ID":17446,"compounds":"H2 + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":20514,"RHEA_ID":17447,"compounds":"2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => H2 + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":20515,"RHEA_ID":17449,"DIRECTION":"UN","MASTER_ID":17449,"ec":"2.5.1.123","compounds":"(2E)-geranyl diphosphate + flaviolin = 3-linalylflaviolin + diphosphate"}
{"X":20516,"RHEA_ID":17450,"compounds":"(2E)-geranyl diphosphate + flaviolin => 3-linalylflaviolin + diphosphate"}
{"X":20517,"RHEA_ID":17451,"compounds":"3-linalylflaviolin + diphosphate => (2E)-geranyl diphosphate + flaviolin"}
{"X":20518,"RHEA_ID":17452,"DIRECTION":"BI","MASTER_ID":17449,"metacyc":"RXN-15421","compounds":"(2E)-geranyl diphosphate + flaviolin <=> 3-linalylflaviolin + diphosphate"}
{"X":20519,"RHEA_ID":17453,"DIRECTION":"UN","MASTER_ID":17453,"ec":"6.3.4.13","compounds":"5-phospho-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-D-ribosyl)glycinamide + phosphate"}
{"X":20520,"RHEA_ID":17454,"DIRECTION":"LR","MASTER_ID":17453,"ecocyc":"GLYRIBONUCSYN-RXN","metacyc":"GLYRIBONUCSYN-RXN","reactome":"R-HSA-73814.2","compounds":"5-phospho-D-ribosylamine + ATP + glycine => ADP + H(+) + N(1)-(5-phospho-D-ribosyl)glycinamide + phosphate"}
{"X":20521,"RHEA_ID":17455,"compounds":"ADP + H(+) + N(1)-(5-phospho-D-ribosyl)glycinamide + phosphate => 5-phospho-D-ribosylamine + ATP + glycine"}
{"X":20522,"RHEA_ID":28111,"compounds":"chloride + S-adenosyl-L-methionine => 5'-chloro-5'-deoxyadenosine + L-methionine"}
{"X":20523,"RHEA_ID":17457,"compounds":"[sulfur-carrier protein]-L-cysteine + L-cysteine = [sulfur-carrier protein]-S-sulfanyl-L-cysteine + L-alanine"}
{"X":20524,"RHEA_ID":17458,"DIRECTION":"LR","MASTER_ID":17457,"ecocyc":"RXN0-308","metacyc":"RXN0-308","compounds":"[sulfur-carrier protein]-L-cysteine + L-cysteine => [sulfur-carrier protein]-S-sulfanyl-L-cysteine + L-alanine"}
{"X":20525,"RHEA_ID":17459,"compounds":"[sulfur-carrier protein]-S-sulfanyl-L-cysteine + L-alanine => [sulfur-carrier protein]-L-cysteine + L-cysteine"}
{"X":20526,"RHEA_ID":17461,"DIRECTION":"UN","MASTER_ID":17461,"ec":"3.1.3.37","compounds":"H2O + sedoheptulose 1,7-bisphosphate = D-sedoheptulose 7-phosphate + phosphate"}
{"X":20527,"RHEA_ID":17462,"DIRECTION":"LR","MASTER_ID":17461,"metacyc":"SEDOHEPTULOSE-BISPHOSPHATASE-RXN","compounds":"H2O + sedoheptulose 1,7-bisphosphate => D-sedoheptulose 7-phosphate + phosphate"}
{"X":20528,"RHEA_ID":17463,"compounds":"D-sedoheptulose 7-phosphate + phosphate => H2O + sedoheptulose 1,7-bisphosphate"}
{"X":20529,"RHEA_ID":28119,"compounds":"di-trans,octa-cis-undecaprenyl phosphate + GDP-alpha-D-mannose => D-mannosyl di-trans,octa-cis-undecaprenyl phosphate + GDP"}
{"X":20530,"RHEA_ID":17465,"DIRECTION":"UN","MASTER_ID":17465,"ec":"3.2.1.66","compounds":"H2O + quercitrin = L-rhamnopyranose + quercetin"}
{"X":20531,"RHEA_ID":17466,"DIRECTION":"LR","MASTER_ID":17465,"metacyc":"QUERCITRINASE-RXN","compounds":"H2O + quercitrin => L-rhamnopyranose + quercetin"}
{"X":20532,"RHEA_ID":17467,"compounds":"L-rhamnopyranose + quercetin => H2O + quercitrin"}
{"X":20533,"RHEA_ID":28123,"compounds":"ATP + di-trans,octa-cis-undecaprenol => ADP + di-trans,octa-cis-undecaprenyl phosphate + H(+)"}
{"X":20534,"RHEA_ID":17469,"DIRECTION":"UN","MASTER_ID":17469,"ec":"2.3.1.135","compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] = a 2-acyl-sn-glycero-3-phosphocholine + an all-trans-retinyl ester + apo--[retinol-binding protein]"}
{"X":20535,"RHEA_ID":17470,"DIRECTION":"LR","MASTER_ID":17469,"metacyc":"2.3.1.135-RXN","compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] => a 2-acyl-sn-glycero-3-phosphocholine + an all-trans-retinyl ester + apo--[retinol-binding protein]"}
{"X":20536,"RHEA_ID":17471,"compounds":"a 2-acyl-sn-glycero-3-phosphocholine + an all-trans-retinyl ester + apo--[retinol-binding protein] => a 1,2-diacyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein]"}
{"X":20537,"RHEA_ID":17473,"DIRECTION":"UN","MASTER_ID":17473,"ec":"3.5.4.16","compounds":"GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)"}
{"X":20538,"RHEA_ID":17474,"DIRECTION":"LR","MASTER_ID":17473,"macie":"M0038","reactome":"R-HSA-1474146.3","compounds":"GTP + H2O => 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)"}
{"X":20539,"RHEA_ID":17475,"compounds":"7,8-dihydroneopterin 3'-triphosphate + formate + H(+) => GTP + H2O"}
{"X":20540,"RHEA_ID":28131,"DIRECTION":"LR","MASTER_ID":28130,"metacyc":"RXN-11760","compounds":"baicalin + H2O => baicalein + D-glucuronate + H(+)"}
{"X":20541,"RHEA_ID":17477,"DIRECTION":"UN","MASTER_ID":17477,"ec":"2.1.1.132","compounds":"precorrin-6B + 2 S-adenosyl-L-methionine = CO2 + 3 H(+) + precorrin-8X + 2 S-adenosyl-L-homocysteine"}
{"X":20542,"RHEA_ID":17478,"DIRECTION":"LR","MASTER_ID":17477,"metacyc":"2.1.1.132-RXN","compounds":"precorrin-6B + 2 S-adenosyl-L-methionine => CO2 + 3 H(+) + precorrin-8X + 2 S-adenosyl-L-homocysteine"}
{"X":20543,"RHEA_ID":17479,"compounds":"CO2 + 3 H(+) + precorrin-8X + 2 S-adenosyl-L-homocysteine => precorrin-6B + 2 S-adenosyl-L-methionine"}
{"X":20544,"RHEA_ID":28135,"DIRECTION":"LR","MASTER_ID":28134,"metacyc":"RXN-11759","compounds":"H2O + hesperidin => hesperetin + rutinose"}
{"X":20545,"RHEA_ID":17481,"DIRECTION":"UN","MASTER_ID":17481,"ec":"1.16.1.4","compounds":"2 cob(I)alamin + H(+) + NAD(+) = 2 cob(II)alamin + NADH"}
{"X":20546,"RHEA_ID":17482,"compounds":"2 cob(I)alamin + H(+) + NAD(+) => 2 cob(II)alamin + NADH"}
{"X":20547,"RHEA_ID":17483,"DIRECTION":"RL","MASTER_ID":17481,"metacyc":"COBIIALAMIN-REDUCTASE-RXN","compounds":"2 cob(II)alamin + NADH => 2 cob(I)alamin + H(+) + NAD(+)"}
{"X":20548,"RHEA_ID":17485,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate"}
{"X":20549,"RHEA_ID":17486,"DIRECTION":"LR","MASTER_ID":17485,"metacyc":"ARACHIDONATE-5-LIPOXYGENASE-RXN","reactome":"R-HSA-265296.1","compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate"}
{"X":20550,"RHEA_ID":17487,"compounds":"(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2"}
{"X":20551,"RHEA_ID":28143,"compounds":"H2O + streptothricin D => streptothricin D acid"}
{"X":20552,"RHEA_ID":17489,"DIRECTION":"UN","MASTER_ID":17489,"ec":"1.14.12.7","compounds":"H(+) + NADH + O2 + phthalate = cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+)"}
{"X":20553,"RHEA_ID":17490,"compounds":"H(+) + NADH + O2 + phthalate => cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+)"}
{"X":20554,"RHEA_ID":17491,"compounds":"cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+) => H(+) + NADH + O2 + phthalate"}
{"X":20555,"RHEA_ID":28147,"DIRECTION":"LR","MASTER_ID":28146,"metacyc":"RXN-8922","compounds":"geranylhydroquinone + O2 + reduced [NADPH--hemoprotein reductase] => 3''-hydroxy-geranylhydroquinone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":20556,"RHEA_ID":17493,"DIRECTION":"UN","MASTER_ID":17493,"ec":"1.1.99.22","compounds":"A + glycerol = AH2 + dihydroxyacetone"}
{"X":20557,"RHEA_ID":17494,"compounds":"A + glycerol => AH2 + dihydroxyacetone"}
{"X":20558,"RHEA_ID":17495,"compounds":"AH2 + dihydroxyacetone => A + glycerol"}
{"X":20559,"RHEA_ID":17497,"DIRECTION":"UN","MASTER_ID":17497,"ec":"2.4.1.170","compounds":"formononetin + UDP-alpha-D-glucose = ononin + UDP"}
{"X":20560,"RHEA_ID":17498,"DIRECTION":"LR","MASTER_ID":17497,"metacyc":"RXN-4761","compounds":"formononetin + UDP-alpha-D-glucose => ononin + UDP"}
{"X":20561,"RHEA_ID":17499,"compounds":"ononin + UDP => formononetin + UDP-alpha-D-glucose"}
{"X":20562,"RHEA_ID":28155,"DIRECTION":"LR","MASTER_ID":28154,"metacyc":"RXN-11323","compounds":"alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate => alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)"}
{"X":20563,"RHEA_ID":17501,"DIRECTION":"UN","MASTER_ID":17501,"ec":"3.1.1.78","compounds":"H2O + polyneuridine aldehyde = 16-epivellosimine + CO2 + methanol"}
{"X":20564,"RHEA_ID":17502,"DIRECTION":"LR","MASTER_ID":17501,"metacyc":"3.1.1.78-RXN","compounds":"H2O + polyneuridine aldehyde => 16-epivellosimine + CO2 + methanol"}
{"X":20565,"RHEA_ID":17503,"compounds":"16-epivellosimine + CO2 + methanol => H2O + polyneuridine aldehyde"}
{"X":20566,"RHEA_ID":28158,"DIRECTION":"UN","MASTER_ID":28158,"ec":"2.4.99.15","compounds":"alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate = alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)"}
{"X":20567,"RHEA_ID":17505,"DIRECTION":"UN","MASTER_ID":17505,"ec":"3.5.1.60","compounds":"H2O + N-(long-chain fatty acyl)ethanolamine = a long-chain fatty acid + ethanolamine"}
{"X":20568,"RHEA_ID":17506,"DIRECTION":"LR","MASTER_ID":17505,"metacyc":"3.5.1.60-RXN","compounds":"H2O + N-(long-chain fatty acyl)ethanolamine => a long-chain fatty acid + ethanolamine"}
{"X":20569,"RHEA_ID":17507,"compounds":"a long-chain fatty acid + ethanolamine => H2O + N-(long-chain fatty acyl)ethanolamine"}
{"X":20570,"RHEA_ID":17509,"DIRECTION":"UN","MASTER_ID":17509,"ec":"3.5.99.2","compounds":"H2O + thiamine = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+)"}
{"X":20571,"RHEA_ID":17510,"DIRECTION":"LR","MASTER_ID":17509,"metacyc":"THIAMINASE-RXN","compounds":"H2O + thiamine => 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+)"}
{"X":20572,"RHEA_ID":17511,"compounds":"4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+) => H2O + thiamine"}
{"X":20573,"RHEA_ID":38022,"compounds":"(9Z)-octadecenoyl-CoA + 1-decanoylglycerol <=> 1-decanoyl-2-(9Z-octadecenoyl)-glycerol + CoA"}
{"X":20574,"RHEA_ID":17517,"DIRECTION":"UN","MASTER_ID":17517,"ec":"3.5.1.55","metacyc":"3.5.1.55-RXN","compounds":"H2O + N-(long-chain-fatty-acyl)-L-glutamate = a long-chain fatty acid + L-glutamate"}
{"X":20575,"RHEA_ID":17518,"compounds":"H2O + N-(long-chain-fatty-acyl)-L-glutamate => a long-chain fatty acid + L-glutamate"}
{"X":20576,"RHEA_ID":17519,"compounds":"a long-chain fatty acid + L-glutamate => H2O + N-(long-chain-fatty-acyl)-L-glutamate"}
{"X":20577,"RHEA_ID":17521,"DIRECTION":"UN","MASTER_ID":17521,"ec":"6.3.5.7","compounds":"ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate"}
{"X":20578,"RHEA_ID":17522,"DIRECTION":"LR","MASTER_ID":17521,"metacyc":"6.3.5.7-RXN","compounds":"ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) => ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate"}
{"X":20579,"RHEA_ID":17523,"compounds":"ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate => ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln)"}
{"X":20580,"RHEA_ID":28173,"compounds":"(2R)-2-hydroxy-2-methylbutanenitrile <=> butan-2-one + hydrogen cyanide"}
{"X":20581,"RHEA_ID":17525,"DIRECTION":"UN","MASTER_ID":17525,"ec":"3.5.1.84","compounds":"biuret + H2O = NH4(+) + urea-1-carboxylate"}
{"X":20582,"RHEA_ID":17526,"DIRECTION":"LR","MASTER_ID":17525,"metacyc":"RXN-8930","compounds":"biuret + H2O => NH4(+) + urea-1-carboxylate"}
{"X":20583,"RHEA_ID":17527,"compounds":"NH4(+) + urea-1-carboxylate => biuret + H2O"}
{"X":20584,"RHEA_ID":38034,"compounds":"(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+) <=> (2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate + CO2"}
{"X":20585,"RHEA_ID":17533,"DIRECTION":"UN","MASTER_ID":17533,"ec":"2.6.1.57","compounds":"2-oxoglutarate + an aromatic L-alpha-amino acid = an aromatic oxo-acid + L-glutamate"}
{"X":20586,"RHEA_ID":17534,"compounds":"2-oxoglutarate + an aromatic L-alpha-amino acid => an aromatic oxo-acid + L-glutamate"}
{"X":20587,"RHEA_ID":17535,"compounds":"an aromatic oxo-acid + L-glutamate => 2-oxoglutarate + an aromatic L-alpha-amino acid"}
{"X":20588,"RHEA_ID":28181,"compounds":"(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate <=> colnelenate + H2O"}
{"X":20589,"RHEA_ID":17537,"DIRECTION":"UN","MASTER_ID":17537,"ec":"3.5.1.73","compounds":"(R)-carnitinamide + H2O = (R)-carnitine + NH4(+)"}
{"X":20590,"RHEA_ID":17538,"DIRECTION":"LR","MASTER_ID":17537,"metacyc":"CARNITINAMIDASE-RXN","compounds":"(R)-carnitinamide + H2O => (R)-carnitine + NH4(+)"}
{"X":20591,"RHEA_ID":17539,"compounds":"(R)-carnitine + NH4(+) => (R)-carnitinamide + H2O"}
{"X":20592,"RHEA_ID":38042,"compounds":"(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a (5Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 H2O"}
{"X":20593,"RHEA_ID":17541,"DIRECTION":"UN","MASTER_ID":17541,"ec":"1.1.3.7","compounds":"an aromatic primary alcohol + O2 = an aromatic aldehyde + H2O2"}
{"X":20594,"RHEA_ID":17542,"DIRECTION":"LR","MASTER_ID":17541,"metacyc":"ARYL-ALCOHOL-OXIDASE-RXN","compounds":"an aromatic primary alcohol + O2 => an aromatic aldehyde + H2O2"}
{"X":20595,"RHEA_ID":17543,"compounds":"an aromatic aldehyde + H2O2 => an aromatic primary alcohol + O2"}
{"X":20596,"RHEA_ID":17545,"DIRECTION":"UN","MASTER_ID":17545,"ec":"1.8.98.2","compounds":"[peroxiredoxin]-S-hydroxy-S-oxy-L-cysteine + [protein]-dithiol + ATP = [peroxiredoxin]-S-hydroxy-L-cysteine + [protein]-disulfide + ADP + H(+) + phosphate"}
{"X":20597,"RHEA_ID":17546,"compounds":"[peroxiredoxin]-S-hydroxy-S-oxy-L-cysteine + [protein]-dithiol + ATP => [peroxiredoxin]-S-hydroxy-L-cysteine + [protein]-disulfide + ADP + H(+) + phosphate"}
{"X":20598,"RHEA_ID":17547,"compounds":"[peroxiredoxin]-S-hydroxy-L-cysteine + [protein]-disulfide + ADP + H(+) + phosphate => [peroxiredoxin]-S-hydroxy-S-oxy-L-cysteine + [protein]-dithiol + ATP"}
{"X":20599,"RHEA_ID":17548,"DIRECTION":"BI","MASTER_ID":17545,"metacyc":"1.8.98.2-RXN","compounds":"[peroxiredoxin]-S-hydroxy-S-oxy-L-cysteine + [protein]-dithiol + ATP <=> [peroxiredoxin]-S-hydroxy-L-cysteine + [protein]-disulfide + ADP + H(+) + phosphate"}
{"X":20600,"RHEA_ID":17549,"DIRECTION":"UN","MASTER_ID":17549,"ec":"2.1.1.16","compounds":"1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine = 1-acyl-2-(10-methylene)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine"}
{"X":20601,"RHEA_ID":17550,"DIRECTION":"LR","MASTER_ID":17549,"metacyc":"2.1.1.16-RXN","compounds":"1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine => 1-acyl-2-(10-methylene)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine"}
{"X":20602,"RHEA_ID":17551,"compounds":"1-acyl-2-(10-methylene)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine => 1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine"}
{"X":20603,"RHEA_ID":38054,"compounds":"2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA <=> 1-butyryl-2-(9Z)-octadecenoyl-sn-glycerol + CoA"}
{"X":20604,"RHEA_ID":17553,"DIRECTION":"UN","MASTER_ID":17553,"ec":"2.7.3.7","metacyc":"OPHELINE-KINASE-RXN","compounds":"ATP + guanidinoethyl methyl phosphate = ADP + H(+) + N'-phosphoguanidinoethyl methylphosphate"}
{"X":20605,"RHEA_ID":17554,"compounds":"ATP + guanidinoethyl methyl phosphate => ADP + H(+) + N'-phosphoguanidinoethyl methylphosphate"}
{"X":20606,"RHEA_ID":17555,"compounds":"ADP + H(+) + N'-phosphoguanidinoethyl methylphosphate => ATP + guanidinoethyl methyl phosphate"}
{"X":20607,"RHEA_ID":47961,"DIRECTION":"LR","MASTER_ID":47960,"metacyc":"RXN-17132","compounds":"H2O + N(tele)-phospho-L-histidyl-[protein] => L-histidyl-[protein] + phosphate"}
{"X":20608,"RHEA_ID":17557,"DIRECTION":"UN","MASTER_ID":17557,"ec":"2.3.1.113","metacyc":"ANTHRANILATE-N-MALONYLTRANSFERASE-RXN","compounds":"anthranilate + malonyl-CoA = CoA + N-malonylanthranilate"}
{"X":20609,"RHEA_ID":17558,"compounds":"anthranilate + malonyl-CoA => CoA + N-malonylanthranilate"}
{"X":20610,"RHEA_ID":17559,"compounds":"CoA + N-malonylanthranilate => anthranilate + malonyl-CoA"}
{"X":20611,"RHEA_ID":38062,"compounds":"2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA <=> 1-octanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA"}
{"X":20612,"RHEA_ID":17561,"DIRECTION":"UN","MASTER_ID":17561,"ec":"3.1.1.7","compounds":"acetylcholine + H2O = acetate + choline + H(+)"}
{"X":20613,"RHEA_ID":17562,"DIRECTION":"LR","MASTER_ID":17561,"reactome":"R-HSA-372519.3","compounds":"acetylcholine + H2O => acetate + choline + H(+)"}
{"X":20614,"RHEA_ID":17563,"compounds":"acetate + choline + H(+) => acetylcholine + H2O"}
{"X":20615,"RHEA_ID":38066,"compounds":"2-(9Z-octadecenoyl)-glycerol + dodecanoyl-CoA <=> 1-dodecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA"}
{"X":20616,"RHEA_ID":17565,"DIRECTION":"UN","MASTER_ID":17565,"ec":"2.1.1.40","compounds":"myo-inositol + S-adenosyl-L-methionine = 1D-1-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine"}
{"X":20617,"RHEA_ID":17566,"DIRECTION":"LR","MASTER_ID":17565,"metacyc":"MYO-INOSITOL-3-O-METHYLTRANSFERASE-RXN","compounds":"myo-inositol + S-adenosyl-L-methionine => 1D-1-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine"}
{"X":20618,"RHEA_ID":17567,"compounds":"1D-1-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine => myo-inositol + S-adenosyl-L-methionine"}
{"X":20619,"RHEA_ID":38070,"compounds":"2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA <=> 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA"}
{"X":20620,"RHEA_ID":17569,"DIRECTION":"UN","MASTER_ID":17569,"ec":"1.5.1.27","compounds":"(R)-reticuline + NADP(+) = 1,2-dehydroreticuline + H(+) + NADPH"}
{"X":20621,"RHEA_ID":17570,"compounds":"(R)-reticuline + NADP(+) => 1,2-dehydroreticuline + H(+) + NADPH"}
{"X":20622,"RHEA_ID":17571,"DIRECTION":"RL","MASTER_ID":17569,"metacyc":"1.5.1.27-RXN","compounds":"1,2-dehydroreticuline + H(+) + NADPH => (R)-reticuline + NADP(+)"}
{"X":20623,"RHEA_ID":38074,"compounds":"2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA"}
{"X":20624,"RHEA_ID":17573,"DIRECTION":"UN","MASTER_ID":17573,"ec":"2.1.1.102","compounds":"demethylmacrocin + S-adenosyl-L-methionine = H(+) + macrocin + S-adenosyl-L-homocysteine"}
{"X":20625,"RHEA_ID":17574,"DIRECTION":"LR","MASTER_ID":17573,"metacyc":"DEMETHYLMACROCIN-O-METHYLTRANSFERASE-RXN","compounds":"demethylmacrocin + S-adenosyl-L-methionine => H(+) + macrocin + S-adenosyl-L-homocysteine"}
{"X":20626,"RHEA_ID":17575,"compounds":"H(+) + macrocin + S-adenosyl-L-homocysteine => demethylmacrocin + S-adenosyl-L-methionine"}
{"X":20627,"RHEA_ID":28220,"compounds":"H2O + hypochlorous acid => chloride + H(+) + H2O2"}
{"X":20628,"RHEA_ID":17577,"DIRECTION":"UN","MASTER_ID":17577,"ec":"5.1.3.20","compounds":"ADP-D-glycero-beta-D-manno-heptose = ADP-L-glycero-beta-D-manno-heptose"}
{"X":20629,"RHEA_ID":17578,"DIRECTION":"LR","MASTER_ID":17577,"ecocyc":"5.1.3.20-RXN","metacyc":"5.1.3.20-RXN","compounds":"ADP-D-glycero-beta-D-manno-heptose => ADP-L-glycero-beta-D-manno-heptose"}
{"X":20630,"RHEA_ID":17579,"compounds":"ADP-L-glycero-beta-D-manno-heptose => ADP-D-glycero-beta-D-manno-heptose"}
{"X":20631,"RHEA_ID":28223,"DIRECTION":"LR","MASTER_ID":28222,"ecocyc":"RXN0-704","metacyc":"RXN0-704","compounds":"3-dehydro-L-gulonate + ATP => 3-dehydro-L-gulonate 6-phosphate + ADP + H(+)"}
{"X":20632,"RHEA_ID":17581,"DIRECTION":"UN","MASTER_ID":17581,"ec":"3.5.1.87","compounds":"an N-carbamoyl-L-2-amino acid + 2 H(+) + H2O = an L-alpha-amino acid + CO2 + NH4(+)"}
{"X":20633,"RHEA_ID":17582,"compounds":"an N-carbamoyl-L-2-amino acid + 2 H(+) + H2O => an L-alpha-amino acid + CO2 + NH4(+)"}
{"X":20634,"RHEA_ID":17583,"compounds":"an L-alpha-amino acid + CO2 + NH4(+) => an N-carbamoyl-L-2-amino acid + 2 H(+) + H2O"}
{"X":20635,"RHEA_ID":17589,"DIRECTION":"UN","MASTER_ID":17589,"ec":"1.5.1.17","compounds":"2,2'-iminodipropanoate + H2O + NAD(+) = H(+) + L-alanine + NADH + pyruvate"}
{"X":20636,"RHEA_ID":17590,"compounds":"2,2'-iminodipropanoate + H2O + NAD(+) => H(+) + L-alanine + NADH + pyruvate"}
{"X":20637,"RHEA_ID":17591,"DIRECTION":"RL","MASTER_ID":17589,"metacyc":"ALANOPINE-DEHYDROGENASE-RXN","compounds":"H(+) + L-alanine + NADH + pyruvate => 2,2'-iminodipropanoate + H2O + NAD(+)"}
{"X":20638,"RHEA_ID":28231,"DIRECTION":"LR","MASTER_ID":28230,"metacyc":"RXN-8971","compounds":"germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => (+)-costunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":20639,"RHEA_ID":17593,"DIRECTION":"UN","MASTER_ID":17593,"ec":"2.6.1.64","compounds":"3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine"}
{"X":20640,"RHEA_ID":17594,"compounds":"3-phenylpyruvate + L-glutamine => 2-oxoglutaramate + L-phenylalanine"}
{"X":20641,"RHEA_ID":17595,"compounds":"2-oxoglutaramate + L-phenylalanine => 3-phenylpyruvate + L-glutamine"}
{"X":20642,"RHEA_ID":28235,"DIRECTION":"LR","MASTER_ID":28234,"reactome":"R-HSA-70655.2","compounds":"L-glutamate 5-semialdehyde => (S)-1-pyrroline-5-carboxylate + H(+) + H2O"}
{"X":20643,"RHEA_ID":17597,"DIRECTION":"UN","MASTER_ID":17597,"ec":"1.1.2.2","metacyc":"MANNITOL-DEHYDROGENASE-CYTOCHROME-RXN","compounds":"2 [Fe(III)cytochrome c] + D-mannitol = 2 [Fe(II)cytochrome c] + D-fructose + 2 H(+)"}
{"X":20644,"RHEA_ID":17598,"compounds":"2 [Fe(III)cytochrome c] + D-mannitol => 2 [Fe(II)cytochrome c] + D-fructose + 2 H(+)"}
{"X":20645,"RHEA_ID":17599,"compounds":"2 [Fe(II)cytochrome c] + D-fructose + 2 H(+) => 2 [Fe(III)cytochrome c] + D-mannitol"}
{"X":20646,"RHEA_ID":28239,"DIRECTION":"LR","MASTER_ID":28238,"metacyc":"RXN-3763","compounds":"calycosin + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + pseudobaptigenin"}
{"X":20647,"RHEA_ID":17601,"DIRECTION":"UN","MASTER_ID":17601,"ec":"2.7.1.47","compounds":"ATP + D-ribulose = ADP + D-ribulose 5-phosphate + H(+)"}
{"X":20648,"RHEA_ID":17601,"DIRECTION":"UN","MASTER_ID":17601,"ec":"2.7.1.16","compounds":"ATP + D-ribulose = ADP + D-ribulose 5-phosphate + H(+)"}
{"X":20649,"RHEA_ID":17602,"compounds":"ATP + D-ribulose => ADP + D-ribulose 5-phosphate + H(+)"}
{"X":20650,"RHEA_ID":17603,"compounds":"ADP + D-ribulose 5-phosphate + H(+) => ATP + D-ribulose"}
{"X":20651,"RHEA_ID":28244,"compounds":"5-hydroxypseudobaptigenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => O2 + pratensein + reduced [NADPH--hemoprotein reductase]"}
{"X":20652,"RHEA_ID":17605,"DIRECTION":"UN","MASTER_ID":17605,"ec":"6.3.2.25","compounds":"ATP + C-terminal detyrosinated L-glutamyl-L-glutamyl-[alpha-tubulin] + L-tyrosine = ADP + C-terminal L-tyrosyl-L-glutamyl-L-glutamyl-[alpha-tubulin] + H(+) + phosphate"}
{"X":20653,"RHEA_ID":17606,"DIRECTION":"LR","MASTER_ID":17605,"metacyc":"6.3.2.25-RXN","compounds":"ATP + C-terminal detyrosinated L-glutamyl-L-glutamyl-[alpha-tubulin] + L-tyrosine => ADP + C-terminal L-tyrosyl-L-glutamyl-L-glutamyl-[alpha-tubulin] + H(+) + phosphate"}
{"X":20654,"RHEA_ID":17607,"compounds":"ADP + C-terminal L-tyrosyl-L-glutamyl-L-glutamyl-[alpha-tubulin] + H(+) + phosphate => ATP + C-terminal detyrosinated L-glutamyl-L-glutamyl-[alpha-tubulin] + L-tyrosine"}
{"X":20655,"RHEA_ID":28248,"compounds":"(R)-4-phosphopantoate + ADP + H(+) => (R)-pantoate + ATP"}
{"X":20656,"RHEA_ID":17613,"DIRECTION":"UN","MASTER_ID":17613,"ec":"1.1.1.370","compounds":"NAD(+) + scyllo-inositol = H(+) + NADH + scyllo-inosose"}
{"X":20657,"RHEA_ID":17614,"compounds":"NAD(+) + scyllo-inositol => H(+) + NADH + scyllo-inosose"}
{"X":20658,"RHEA_ID":17615,"compounds":"H(+) + NADH + scyllo-inosose => NAD(+) + scyllo-inositol"}
{"X":20659,"RHEA_ID":28252,"compounds":"acetoacetyl-CoA + CO2 + CoA => acetyl-CoA + H(+) + malonyl-CoA"}
{"X":20660,"RHEA_ID":17617,"DIRECTION":"UN","MASTER_ID":17617,"ec":"4.4.1.20","compounds":"leukotriene C4 = glutathione + leukotriene A4"}
{"X":20661,"RHEA_ID":17618,"compounds":"leukotriene C4 => glutathione + leukotriene A4"}
{"X":20662,"RHEA_ID":17619,"DIRECTION":"RL","MASTER_ID":17617,"metacyc":"LEUKOTRIENE-C4-SYNTHASE-RXN","reactome":"R-HSA-266050.1","compounds":"glutathione + leukotriene A4 => leukotriene C4"}
{"X":20663,"RHEA_ID":28256,"compounds":"(3Z)-hex-3-en-1-yl acetate + CoA => (3Z)-hex-3-en-1-ol + acetyl-CoA"}
{"X":20664,"RHEA_ID":17621,"DIRECTION":"UN","MASTER_ID":17621,"ec":"2.8.3.11","metacyc":"CITRAMALATE-COA-TRANSFERASE-RXN","compounds":"acetyl-CoA + citramalate = (3S)-citramalyl-CoA + acetate"}
{"X":20665,"RHEA_ID":17622,"compounds":"acetyl-CoA + citramalate => (3S)-citramalyl-CoA + acetate"}
{"X":20666,"RHEA_ID":17623,"compounds":"(3S)-citramalyl-CoA + acetate => acetyl-CoA + citramalate"}
{"X":20667,"RHEA_ID":28260,"compounds":"cyanidin 3-O-(2-O-beta-D-glucuronosyl)-beta-D-glucoside + H(+) + UDP => cyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucuronate"}
{"X":20668,"RHEA_ID":17625,"DIRECTION":"UN","MASTER_ID":17625,"ec":"1.5.1.16","compounds":"D-lysopine + H2O + NADP(+) = H(+) + L-lysine + NADPH + pyruvate"}
{"X":20669,"RHEA_ID":17626,"compounds":"D-lysopine + H2O + NADP(+) => H(+) + L-lysine + NADPH + pyruvate"}
{"X":20670,"RHEA_ID":17627,"DIRECTION":"RL","MASTER_ID":17625,"metacyc":"D-LYSOPINE-DEHYDROGENASE-RXN","compounds":"H(+) + L-lysine + NADPH + pyruvate => D-lysopine + H2O + NADP(+)"}
{"X":20671,"RHEA_ID":28264,"compounds":"3-O-(6-O-alpha-D-xylosylphospho-alpha-D-mannopyranosyl)-alpha-D-mannopyranose + H(+) + UMP => 3-alpha-D-mannopyranosyl-alpha-D-mannopyranose + UDP-alpha-D-xylose"}
{"X":20672,"RHEA_ID":17629,"compounds":"alpha,alpha-trehalose(in) = alpha,alpha-trehalose(out)"}
{"X":20673,"RHEA_ID":17630,"compounds":"alpha,alpha-trehalose(in) => alpha,alpha-trehalose(out)"}
{"X":20674,"RHEA_ID":17631,"compounds":"alpha,alpha-trehalose(out) => alpha,alpha-trehalose(in)"}
{"X":20675,"RHEA_ID":17632,"compounds":"alpha,alpha-trehalose(in) <=> alpha,alpha-trehalose(out)"}
{"X":20676,"RHEA_ID":17633,"DIRECTION":"UN","MASTER_ID":17633,"ec":"3.2.1.31","compounds":"a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate"}
{"X":20677,"RHEA_ID":17634,"DIRECTION":"LR","MASTER_ID":17633,"ecocyc":"BETA-GLUCURONID-RXN","metacyc":"BETA-GLUCURONID-RXN","compounds":"a beta-D-glucuronoside + H2O => an alcohol + D-glucuronate"}
{"X":20678,"RHEA_ID":17635,"compounds":"an alcohol + D-glucuronate => a beta-D-glucuronoside + H2O"}
{"X":20679,"RHEA_ID":17637,"DIRECTION":"UN","MASTER_ID":17637,"ec":"5.4.99.17","compounds":"squalene = hop-22(29)-ene"}
{"X":20680,"RHEA_ID":17638,"DIRECTION":"LR","MASTER_ID":17637,"macie":"M0254","metacyc":"5.4.99.17-RXN","compounds":"squalene => hop-22(29)-ene"}
{"X":20681,"RHEA_ID":17639,"compounds":"hop-22(29)-ene => squalene"}
{"X":20682,"RHEA_ID":28276,"compounds":"(R)-S-adenosyl-L-methionine => (S)-S-adenosyl-L-methionine"}
{"X":20683,"RHEA_ID":17641,"DIRECTION":"UN","MASTER_ID":17641,"ec":"4.1.1.19","compounds":"H(+) + L-arginine = agmatine + CO2"}
{"X":20684,"RHEA_ID":17642,"DIRECTION":"LR","MASTER_ID":17641,"ecocyc":"ARGDECARBOX-RXN","reactome":"R-HSA-350598.1","compounds":"H(+) + L-arginine => agmatine + CO2"}
{"X":20685,"RHEA_ID":17643,"compounds":"agmatine + CO2 => H(+) + L-arginine"}
{"X":20686,"RHEA_ID":28280,"compounds":"H(+) + L-alanine + sulfite => 3-sulfino-L-alanine + H2O"}
{"X":20687,"RHEA_ID":17645,"compounds":"H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein] = N(6)-D-ribulosyl-L-lysyl-[protein] + phosphate"}
{"X":20688,"RHEA_ID":17646,"compounds":"H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein] => N(6)-D-ribulosyl-L-lysyl-[protein] + phosphate"}
{"X":20689,"RHEA_ID":17647,"compounds":"N(6)-D-ribulosyl-L-lysyl-[protein] + phosphate => H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein]"}
{"X":20690,"RHEA_ID":17648,"compounds":"H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein] <=> N(6)-D-ribulosyl-L-lysyl-[protein] + phosphate"}
{"X":20691,"RHEA_ID":17649,"DIRECTION":"UN","MASTER_ID":17649,"ec":"2.3.1.187","compounds":"acetyl-[ACP] + malonate = acetate + malonyl-[ACP]"}
{"X":20692,"RHEA_ID":17650,"DIRECTION":"LR","MASTER_ID":17649,"metacyc":"RXN-9729","compounds":"acetyl-[ACP] + malonate => acetate + malonyl-[ACP]"}
{"X":20693,"RHEA_ID":17651,"compounds":"acetate + malonyl-[ACP] => acetyl-[ACP] + malonate"}
{"X":20694,"RHEA_ID":17653,"DIRECTION":"UN","MASTER_ID":17653,"ec":"2.5.1.29","compounds":"(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = all-trans-geranylgeranyl diphosphate + diphosphate"}
{"X":20695,"RHEA_ID":17654,"DIRECTION":"LR","MASTER_ID":17653,"metacyc":"FARNESYLTRANSTRANSFERASE-RXN","compounds":"(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate => all-trans-geranylgeranyl diphosphate + diphosphate"}
{"X":20696,"RHEA_ID":17655,"compounds":"all-trans-geranylgeranyl diphosphate + diphosphate => (2E,6E)-farnesyl diphosphate + isopentenyl diphosphate"}
{"X":20697,"RHEA_ID":28292,"compounds":"(5S,9S,10S)-drim-7-en-11-ol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}
{"X":20698,"RHEA_ID":17657,"DIRECTION":"UN","MASTER_ID":17657,"ec":"2.3.1.42","compounds":"an acyl-CoA + dihydroxyacetone phosphate = a 1-acylglycerone 3-phosphate + CoA"}
{"X":20699,"RHEA_ID":17658,"compounds":"an acyl-CoA + dihydroxyacetone phosphate => a 1-acylglycerone 3-phosphate + CoA"}
{"X":20700,"RHEA_ID":17659,"compounds":"a 1-acylglycerone 3-phosphate + CoA => an acyl-CoA + dihydroxyacetone phosphate"}
{"X":20701,"RHEA_ID":28296,"compounds":"(-)-beta-caryophyllene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":20702,"RHEA_ID":17661,"DIRECTION":"UN","MASTER_ID":17661,"ec":"6.2.1.5","compounds":"ATP + CoA + succinate = ADP + phosphate + succinyl-CoA"}
{"X":20703,"RHEA_ID":17662,"compounds":"ATP + CoA + succinate => ADP + phosphate + succinyl-CoA"}
{"X":20704,"RHEA_ID":17663,"DIRECTION":"RL","MASTER_ID":17661,"reactome":"R-HSA-70997.3","compounds":"ADP + phosphate + succinyl-CoA => ATP + CoA + succinate"}
{"X":20705,"RHEA_ID":28300,"compounds":"(E)-gamma-bisabolene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":20706,"RHEA_ID":17665,"DIRECTION":"UN","MASTER_ID":17665,"ec":"2.3.1.181","compounds":"L-lysyl-[protein] + octanoyl-[ACP] = H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]"}
{"X":20707,"RHEA_ID":17666,"DIRECTION":"LR","MASTER_ID":17665,"ecocyc":"RXN0-947","metacyc":"RXN0-947","compounds":"L-lysyl-[protein] + octanoyl-[ACP] => H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]"}
{"X":20708,"RHEA_ID":17667,"compounds":"H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein] => L-lysyl-[protein] + octanoyl-[ACP]"}
{"X":20709,"RHEA_ID":17669,"DIRECTION":"UN","MASTER_ID":17669,"ec":"1.14.13.4","compounds":"3-(2-hydroxyphenyl)propanoate + H(+) + NADH + O2 = 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+)"}
{"X":20710,"RHEA_ID":17670,"DIRECTION":"LR","MASTER_ID":17669,"metacyc":"MELILOTATE-3-MONOOXYGENASE-RXN","compounds":"3-(2-hydroxyphenyl)propanoate + H(+) + NADH + O2 => 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+)"}
{"X":20711,"RHEA_ID":17671,"compounds":"3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+) => 3-(2-hydroxyphenyl)propanoate + H(+) + NADH + O2"}
{"X":20712,"RHEA_ID":28308,"compounds":"beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+) => beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose"}
{"X":20713,"RHEA_ID":17673,"DIRECTION":"UN","MASTER_ID":17673,"ec":"2.1.1.76","compounds":"quercetin + S-adenosyl-L-methionine = 3',4',5,7-tetrahydroxy-3-methoxyflavone + H(+) + S-adenosyl-L-homocysteine"}
{"X":20714,"RHEA_ID":17674,"DIRECTION":"LR","MASTER_ID":17673,"metacyc":"QUERCETIN-3-O-METHYLTRANSFERASE-RXN","compounds":"quercetin + S-adenosyl-L-methionine => 3',4',5,7-tetrahydroxy-3-methoxyflavone + H(+) + S-adenosyl-L-homocysteine"}
{"X":20715,"RHEA_ID":17675,"compounds":"3',4',5,7-tetrahydroxy-3-methoxyflavone + H(+) + S-adenosyl-L-homocysteine => quercetin + S-adenosyl-L-methionine"}
{"X":20716,"RHEA_ID":28312,"compounds":"alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+) => beta-D-Glc-(1->4)-alpha-D-Glc-1-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose"}
{"X":20717,"RHEA_ID":17677,"DIRECTION":"UN","MASTER_ID":17677,"ec":"3.5.1.66","compounds":"2-(acetamidomethylene)-3-(hydroxymethyl)succinate + H(+) + 2 H2O = 2-(hydroxymethyl)-4-oxobutanoate + acetate + CO2 + NH4(+)"}
{"X":20718,"RHEA_ID":17678,"DIRECTION":"LR","MASTER_ID":17677,"metacyc":"3.5.1.66-RXN","compounds":"2-(acetamidomethylene)-3-(hydroxymethyl)succinate + H(+) + 2 H2O => 2-(hydroxymethyl)-4-oxobutanoate + acetate + CO2 + NH4(+)"}
{"X":20719,"RHEA_ID":17679,"compounds":"2-(hydroxymethyl)-4-oxobutanoate + acetate + CO2 + NH4(+) => 2-(acetamidomethylene)-3-(hydroxymethyl)succinate + H(+) + 2 H2O"}
{"X":20720,"RHEA_ID":28316,"compounds":"baicalin + UDP => baicalein + UDP-alpha-D-glucuronate"}
{"X":20721,"RHEA_ID":17681,"DIRECTION":"UN","MASTER_ID":17681,"ec":"1.1.1.31","compounds":"3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + H(+) + NADH"}
{"X":20722,"RHEA_ID":17682,"DIRECTION":"LR","MASTER_ID":17681,"reactome":"R-HSA-70885.2","compounds":"3-hydroxy-2-methylpropanoate + NAD(+) => 2-methyl-3-oxopropanoate + H(+) + NADH"}
{"X":20723,"RHEA_ID":17683,"DIRECTION":"RL","MASTER_ID":17681,"reactome":"R-HSA-508473.1","compounds":"2-methyl-3-oxopropanoate + H(+) + NADH => 3-hydroxy-2-methylpropanoate + NAD(+)"}
{"X":20724,"RHEA_ID":28320,"compounds":"scutellarin + UDP => scutellarein + UDP-alpha-D-glucuronate"}
{"X":20725,"RHEA_ID":17685,"DIRECTION":"UN","MASTER_ID":17685,"ec":"4.1.1.66","compounds":"H(+) + uracil 5-carboxylate = CO2 + uracil"}
{"X":20726,"RHEA_ID":17686,"DIRECTION":"LR","MASTER_ID":17685,"metacyc":"URACIL-5-CARBOXYLATE-DECARBOXYLASE-RXN","compounds":"H(+) + uracil 5-carboxylate => CO2 + uracil"}
{"X":20727,"RHEA_ID":17687,"compounds":"CO2 + uracil => H(+) + uracil 5-carboxylate"}
{"X":20728,"RHEA_ID":28324,"compounds":"UDP + wogonin 7-O-beta-D-glucuronate => UDP-alpha-D-glucuronate + wogonin"}
{"X":20729,"RHEA_ID":17689,"DIRECTION":"UN","MASTER_ID":17689,"ec":"2.8.2.34","metacyc":"2.8.2.34-RXN","compounds":"3'-phosphoadenylyl sulfate + glycochenodeoxycholate = adenosine 3',5'-bisphosphate + glycochenodeoxycholate 7-sulfate + H(+)"}
{"X":20730,"RHEA_ID":17690,"compounds":"3'-phosphoadenylyl sulfate + glycochenodeoxycholate => adenosine 3',5'-bisphosphate + glycochenodeoxycholate 7-sulfate + H(+)"}
{"X":20731,"RHEA_ID":17691,"compounds":"adenosine 3',5'-bisphosphate + glycochenodeoxycholate 7-sulfate + H(+) => 3'-phosphoadenylyl sulfate + glycochenodeoxycholate"}
{"X":20732,"RHEA_ID":28328,"compounds":"D-glucuronate + H(+) + wogonin => H2O + wogonin 7-O-beta-D-glucuronate"}
{"X":20733,"RHEA_ID":17693,"compounds":"deoxycholoyl-CoA + H2O = CoA + deoxycholate + H(+)"}
{"X":20734,"RHEA_ID":17694,"DIRECTION":"LR","MASTER_ID":17693,"metacyc":"BACOAHYDRO-RXN","compounds":"deoxycholoyl-CoA + H2O => CoA + deoxycholate + H(+)"}
{"X":20735,"RHEA_ID":17695,"compounds":"CoA + deoxycholate + H(+) => deoxycholoyl-CoA + H2O"}
{"X":20736,"RHEA_ID":28332,"compounds":"H(+) + IDP + phosphate => H2O + ITP"}
{"X":20737,"RHEA_ID":17697,"DIRECTION":"UN","MASTER_ID":17697,"ec":"2.5.1.2","compounds":"pyridine + thiamine = 5-(2-hydroxyethyl)-4-methylthiazole + heteropyrithiamine"}
{"X":20738,"RHEA_ID":17698,"compounds":"pyridine + thiamine => 5-(2-hydroxyethyl)-4-methylthiazole + heteropyrithiamine"}
{"X":20739,"RHEA_ID":17699,"compounds":"5-(2-hydroxyethyl)-4-methylthiazole + heteropyrithiamine => pyridine + thiamine"}
{"X":20740,"RHEA_ID":28336,"compounds":"dAMP + diphosphate + H(+) => dATP + H2O"}
{"X":20741,"RHEA_ID":17701,"DIRECTION":"UN","MASTER_ID":17701,"ec":"6.4.1.5","compounds":"ATP + geranoyl-CoA + hydrogencarbonate = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + H(+) + phosphate"}
{"X":20742,"RHEA_ID":17702,"DIRECTION":"LR","MASTER_ID":17701,"metacyc":"GERANOYL-COA-CARBOXYLASE-RXN","compounds":"ATP + geranoyl-CoA + hydrogencarbonate => 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + H(+) + phosphate"}
{"X":20743,"RHEA_ID":17703,"compounds":"3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + H(+) + phosphate => ATP + geranoyl-CoA + hydrogencarbonate"}
{"X":20744,"RHEA_ID":28340,"compounds":"crotonobetainyl-CoA + H2O => (R)-carnitinyl-CoA"}
{"X":20745,"RHEA_ID":17709,"DIRECTION":"UN","MASTER_ID":17709,"ec":"2.5.1.39","compounds":"4-hydroxybenzoate + all-trans-nonaprenyl diphosphate = 4-hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate"}
{"X":20746,"RHEA_ID":17710,"DIRECTION":"LR","MASTER_ID":17709,"metacyc":"2.5.1.39-RXN","compounds":"4-hydroxybenzoate + all-trans-nonaprenyl diphosphate => 4-hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate"}
{"X":20747,"RHEA_ID":17711,"compounds":"4-hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate => 4-hydroxybenzoate + all-trans-nonaprenyl diphosphate"}
{"X":20748,"RHEA_ID":28343,"DIRECTION":"LR","MASTER_ID":28342,"ecocyc":"RXN0-1602","metacyc":"RXN0-1602","reactome":"R-HSA-2509838.4","compounds":"dITP + H2O => dIMP + diphosphate + H(+)"}
{"X":20749,"RHEA_ID":17713,"DIRECTION":"UN","MASTER_ID":17713,"ec":"1.14.19.67","compounds":"(R)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + salutaridine"}
{"X":20750,"RHEA_ID":17714,"DIRECTION":"LR","MASTER_ID":17713,"metacyc":"1.1.3.35-RXN","compounds":"(R)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + salutaridine"}
{"X":20751,"RHEA_ID":17715,"compounds":"H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + salutaridine => (R)-reticuline + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":20752,"RHEA_ID":28347,"compounds":"7,8-dihydroneopterin 3'-triphosphate => 7,8-dihydromonapterin 3'-triphosphate"}
{"X":20753,"RHEA_ID":17717,"compounds":"1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + H(+)"}
{"X":20754,"RHEA_ID":17718,"DIRECTION":"LR","MASTER_ID":17717,"metacyc":"2.7.1.151-RXN","compounds":"1D-myo-inositol 1,4,5-trisphosphate + ATP => 1D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + H(+)"}
{"X":20755,"RHEA_ID":17719,"compounds":"1D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + H(+) => 1D-myo-inositol 1,4,5-trisphosphate + ATP"}
{"X":20756,"RHEA_ID":28351,"compounds":"UDP-beta-L-arabinofuranose => UDP-beta-L-arabinopyranose"}
{"X":20757,"RHEA_ID":17721,"DIRECTION":"UN","MASTER_ID":17721,"ec":"1.3.8.8","compounds":"a long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":20758,"RHEA_ID":17722,"compounds":"a long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":20759,"RHEA_ID":17723,"compounds":"a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein] => a long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":20760,"RHEA_ID":17725,"DIRECTION":"UN","MASTER_ID":17725,"ec":"4.2.1.79","compounds":"(2S,3S)-2-methylcitrate = 2-methyl-cis-aconitate + H2O"}
{"X":20761,"RHEA_ID":17726,"DIRECTION":"LR","MASTER_ID":17725,"ecocyc":"2-METHYLCITRATE-DEHYDRATASE-RXN","compounds":"(2S,3S)-2-methylcitrate => 2-methyl-cis-aconitate + H2O"}
{"X":20762,"RHEA_ID":17727,"compounds":"2-methyl-cis-aconitate + H2O => (2S,3S)-2-methylcitrate"}
{"X":20763,"RHEA_ID":28359,"DIRECTION":"LR","MASTER_ID":28358,"reactome":"R-HSA-77274.2","compounds":"FAD + H(+) + tetradecanoyl-CoA => (2E)-tetradecenoyl-CoA + FADH2"}
{"X":20764,"RHEA_ID":17729,"DIRECTION":"UN","MASTER_ID":17729,"ec":"2.3.1.26","metacyc":"STEROL-O-ACYLTRANSFERASE-RXN","compounds":"an acyl-CoA + cholesterol = a cholesterol ester + CoA"}
{"X":20765,"RHEA_ID":17730,"compounds":"an acyl-CoA + cholesterol => a cholesterol ester + CoA"}
{"X":20766,"RHEA_ID":17731,"compounds":"a cholesterol ester + CoA => an acyl-CoA + cholesterol"}
{"X":20767,"RHEA_ID":28363,"compounds":"dGTP + H2O => dGMP + diphosphate + H(+)"}
{"X":20768,"RHEA_ID":17733,"DIRECTION":"UN","MASTER_ID":17733,"ec":"4.1.1.78","metacyc":"4.1.1.78-RXN","compounds":"acetylenedicarboxylate + H(+) + H2O = CO2 + pyruvate"}
{"X":20769,"RHEA_ID":17734,"compounds":"acetylenedicarboxylate + H(+) + H2O => CO2 + pyruvate"}
{"X":20770,"RHEA_ID":17735,"compounds":"CO2 + pyruvate => acetylenedicarboxylate + H(+) + H2O"}
{"X":20771,"RHEA_ID":17737,"DIRECTION":"UN","MASTER_ID":17737,"ec":"1.1.1.25","compounds":"NADP(+) + shikimate = 3-dehydroshikimate + H(+) + NADPH"}
{"X":20772,"RHEA_ID":17737,"DIRECTION":"UN","MASTER_ID":17737,"ec":"1.1.1.282","compounds":"NADP(+) + shikimate = 3-dehydroshikimate + H(+) + NADPH"}
{"X":20773,"RHEA_ID":17738,"DIRECTION":"LR","MASTER_ID":17737,"ecocyc":"RXN-7968","metacyc":"RXN-7968","compounds":"NADP(+) + shikimate => 3-dehydroshikimate + H(+) + NADPH"}
{"X":20774,"RHEA_ID":17739,"DIRECTION":"RL","MASTER_ID":17737,"ecocyc":"SHIKIMATE-5-DEHYDROGENASE-RXN","metacyc":"SHIKIMATE-5-DEHYDROGENASE-RXN","compounds":"3-dehydroshikimate + H(+) + NADPH => NADP(+) + shikimate"}
{"X":20775,"RHEA_ID":28372,"compounds":"hydrogencarbonate + phosphoenolpyruvate => oxaloacetate + phosphate"}
{"X":20776,"RHEA_ID":17741,"DIRECTION":"UN","MASTER_ID":17741,"ec":"1.1.1.282","compounds":"NAD(+) + shikimate = 3-dehydroshikimate + H(+) + NADH"}
{"X":20777,"RHEA_ID":17742,"DIRECTION":"LR","MASTER_ID":17741,"ecocyc":"RXN-7968","metacyc":"RXN-7968","compounds":"NAD(+) + shikimate => 3-dehydroshikimate + H(+) + NADH"}
{"X":20778,"RHEA_ID":17742,"DIRECTION":"LR","MASTER_ID":17741,"ecocyc":"RXN-7968","metacyc":"RXN-11174","compounds":"NAD(+) + shikimate => 3-dehydroshikimate + H(+) + NADH"}
{"X":20779,"RHEA_ID":17743,"DIRECTION":"RL","MASTER_ID":17741,"ecocyc":"RXN-7968","metacyc":"RXN-7968","compounds":"3-dehydroshikimate + H(+) + NADH => NAD(+) + shikimate"}
{"X":20780,"RHEA_ID":38236,"compounds":"(9Z)-octadecenoyl-CoA + octadecan-1-ol => 1-O-octadecyl (9Z)-octadecenoate + CoA"}
{"X":20781,"RHEA_ID":17745,"DIRECTION":"UN","MASTER_ID":17745,"ec":"2.4.1.90","compounds":"N-acetyl-D-glucosamine + UDP-alpha-D-galactose = beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + H(+) + UDP"}
{"X":20782,"RHEA_ID":17746,"compounds":"N-acetyl-D-glucosamine + UDP-alpha-D-galactose => beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + H(+) + UDP"}
{"X":20783,"RHEA_ID":17747,"compounds":"beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + H(+) + UDP => N-acetyl-D-glucosamine + UDP-alpha-D-galactose"}
{"X":20784,"RHEA_ID":38240,"compounds":"(9Z)-octadecen-1-ol + (9Z)-octadecenoyl-CoA => 1-O-(9Z)-octadecenyl (9Z)-octadecenoate + CoA"}
{"X":20785,"RHEA_ID":17749,"DIRECTION":"UN","MASTER_ID":17749,"ec":"1.3.99.17","compounds":"A + H2O + quinoline = AH2 + quinolin-2(1H)-one"}
{"X":20786,"RHEA_ID":17750,"compounds":"A + H2O + quinoline => AH2 + quinolin-2(1H)-one"}
{"X":20787,"RHEA_ID":17751,"compounds":"AH2 + quinolin-2(1H)-one => A + H2O + quinoline"}
{"X":20788,"RHEA_ID":38244,"compounds":"(9Z)-octadecenoyl-CoA + eicosan-1-ol => 1-O-eicosanyl (9Z)-octadecenoate + CoA"}
{"X":20789,"RHEA_ID":17753,"DIRECTION":"UN","MASTER_ID":17753,"ec":"4.4.1.21","compounds":"S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine"}
{"X":20790,"RHEA_ID":17754,"DIRECTION":"LR","MASTER_ID":17753,"ecocyc":"RIBOSYLHOMOCYSTEINASE-RXN","metacyc":"RIBOSYLHOMOCYSTEINASE-RXN","compounds":"S-(5-deoxy-D-ribos-5-yl)-L-homocysteine => (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine"}
{"X":20791,"RHEA_ID":17755,"compounds":"(S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine => S-(5-deoxy-D-ribos-5-yl)-L-homocysteine"}
{"X":20792,"RHEA_ID":38248,"compounds":"(9Z)-hexadecenoyl-CoA + hexadecan-1-ol => 1-O-hexadecyl (9Z)-hexadecenoate + CoA"}
{"X":20793,"RHEA_ID":17757,"DIRECTION":"UN","MASTER_ID":17757,"ec":"4.1.1.57","metacyc":"METHIONINE-DECARBOXYLASE-RXN","compounds":"H(+) + L-methionine = 3-(methylsulfanyl)propanamine + CO2"}
{"X":20794,"RHEA_ID":17758,"compounds":"H(+) + L-methionine => 3-(methylsulfanyl)propanamine + CO2"}
{"X":20795,"RHEA_ID":17759,"compounds":"3-(methylsulfanyl)propanamine + CO2 => H(+) + L-methionine"}
{"X":20796,"RHEA_ID":38252,"compounds":"hexadecan-1-ol + octadecanoyl-CoA => CoA + hexadecanyl octadecanoate"}
{"X":20797,"RHEA_ID":17761,"DIRECTION":"UN","MASTER_ID":17761,"ec":"1.1.1.91","compounds":"an aromatic primary alcohol + NADP(+) = an aromatic aldehyde + H(+) + NADPH"}
{"X":20798,"RHEA_ID":17762,"compounds":"an aromatic primary alcohol + NADP(+) => an aromatic aldehyde + H(+) + NADPH"}
{"X":20799,"RHEA_ID":17763,"compounds":"an aromatic aldehyde + H(+) + NADPH => an aromatic primary alcohol + NADP(+)"}
{"X":20800,"RHEA_ID":28397,"DIRECTION":"BI","MASTER_ID":28394,"ecocyc":"RXN0-5228","metacyc":"RXN0-5228","compounds":"L-alanyl-L-glutamate <=> L-alanyl-D-glutamate"}
{"X":20801,"RHEA_ID":17765,"DIRECTION":"UN","MASTER_ID":17765,"ec":"5.4.2.4","compounds":"(2R)-3-phospho-glyceroyl phosphate = (2R)-2,3-bisphosphoglycerate + H(+)"}
{"X":20802,"RHEA_ID":17766,"DIRECTION":"LR","MASTER_ID":17765,"metacyc":"BISPHOSPHOGLYCERATE-MUTASE-RXN","compounds":"(2R)-3-phospho-glyceroyl phosphate => (2R)-2,3-bisphosphoglycerate + H(+)"}
{"X":20803,"RHEA_ID":17767,"compounds":"(2R)-2,3-bisphosphoglycerate + H(+) => (2R)-3-phospho-glyceroyl phosphate"}
{"X":20804,"RHEA_ID":28401,"compounds":"H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate <=> L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate"}
{"X":20805,"RHEA_ID":17769,"DIRECTION":"UN","MASTER_ID":17769,"ec":"1.14.15.7","compounds":"choline + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = betaine aldehyde hydrate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":20806,"RHEA_ID":17770,"DIRECTION":"LR","MASTER_ID":17769,"metacyc":"RXN1F-357","compounds":"choline + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => betaine aldehyde hydrate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":20807,"RHEA_ID":17771,"compounds":"betaine aldehyde hydrate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => choline + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":20808,"RHEA_ID":28405,"compounds":"ADP-L-glycero-beta-D-manno-heptose + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A <=> ADP + H(+) + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A"}
{"X":20809,"RHEA_ID":28406,"compounds":"H2O + XTP = H(+) + phosphate + XDP"}
{"X":20810,"RHEA_ID":17773,"DIRECTION":"UN","MASTER_ID":17773,"ec":"6.1.1.16","compounds":"ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)"}
{"X":20811,"RHEA_ID":17774,"DIRECTION":"LR","MASTER_ID":17773,"ecocyc":"CYSTEINE--TRNA-LIGASE-RXN","metacyc":"CYSTEINE--TRNA-LIGASE-RXN","compounds":"ATP + L-cysteine + tRNA(Cys) => AMP + diphosphate + L-cysteinyl-tRNA(Cys)"}
{"X":20812,"RHEA_ID":17775,"compounds":"AMP + diphosphate + L-cysteinyl-tRNA(Cys) => ATP + L-cysteine + tRNA(Cys)"}
{"X":20813,"RHEA_ID":28410,"DIRECTION":"UN","MASTER_ID":28410,"ec":"1.2.1.99","compounds":"4-(gamma-L-glutamylamino)butanal + H2O + NADP(+) = 4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADPH"}
{"X":20814,"RHEA_ID":17777,"DIRECTION":"UN","MASTER_ID":17777,"ec":"3.1.1.47","compounds":"1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)"}
{"X":20815,"RHEA_ID":17778,"DIRECTION":"LR","MASTER_ID":17777,"metacyc":"3.1.1.47-RXN","compounds":"1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)"}
{"X":20816,"RHEA_ID":17779,"compounds":"1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O"}
{"X":20817,"RHEA_ID":17781,"DIRECTION":"UN","MASTER_ID":17781,"ec":"3.5.1.31","compounds":"H2O + N-formyl-L-methionine = formate + L-methionine"}
{"X":20818,"RHEA_ID":17782,"DIRECTION":"LR","MASTER_ID":17781,"metacyc":"FORMYLMETHIONINE-DEFORMYLASE-RXN","compounds":"H2O + N-formyl-L-methionine => formate + L-methionine"}
{"X":20819,"RHEA_ID":17783,"compounds":"formate + L-methionine => H2O + N-formyl-L-methionine"}
{"X":20820,"RHEA_ID":28418,"DIRECTION":"UN","MASTER_ID":28418,"ec":"2.8.3.21","compounds":"(R)-carnitine + gamma-butyrobetainyl-CoA = (R)-carnitinyl-CoA + 4-(trimethylamino)butanoate"}
{"X":20821,"RHEA_ID":17785,"DIRECTION":"UN","MASTER_ID":17785,"ec":"4.1.1.15","compounds":"H(+) + L-glutamate = 4-aminobutanoate + CO2"}
{"X":20822,"RHEA_ID":17786,"DIRECTION":"LR","MASTER_ID":17785,"ecocyc":"GLUTDECARBOX-RXN","metacyc":"GLUTDECARBOX-RXN","reactome":"R-HSA-888572.2","compounds":"H(+) + L-glutamate => 4-aminobutanoate + CO2"}
{"X":20823,"RHEA_ID":17786,"DIRECTION":"LR","MASTER_ID":17785,"ecocyc":"GLUTDECARBOX-RXN","metacyc":"GLUTDECARBOX-RXN","reactome":"R-HSA-888577.2","compounds":"H(+) + L-glutamate => 4-aminobutanoate + CO2"}
{"X":20824,"RHEA_ID":17787,"compounds":"4-aminobutanoate + CO2 => H(+) + L-glutamate"}
{"X":20825,"RHEA_ID":28423,"DIRECTION":"LR","MASTER_ID":28422,"metacyc":"RXN-14132","compounds":"(1E,2S)-2-methylbutanal oxime + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-2-methylbutanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":20826,"RHEA_ID":17789,"DIRECTION":"UN","MASTER_ID":17789,"ec":"2.1.1.116","compounds":"(S)-3'-hydroxy-N-methylcoclaurine + S-adenosyl-L-methionine = (S)-reticuline + H(+) + S-adenosyl-L-homocysteine"}
{"X":20827,"RHEA_ID":17790,"DIRECTION":"LR","MASTER_ID":17789,"metacyc":"2.1.1.116-RXN","compounds":"(S)-3'-hydroxy-N-methylcoclaurine + S-adenosyl-L-methionine => (S)-reticuline + H(+) + S-adenosyl-L-homocysteine"}
{"X":20828,"RHEA_ID":17791,"compounds":"(S)-reticuline + H(+) + S-adenosyl-L-homocysteine => (S)-3'-hydroxy-N-methylcoclaurine + S-adenosyl-L-methionine"}
{"X":20829,"RHEA_ID":28427,"DIRECTION":"LR","MASTER_ID":28426,"ecocyc":"RXN0-304","metacyc":"RXN0-304","compounds":"D-allulose 6-phosphate => keto-D-fructose 6-phosphate"}
{"X":20830,"RHEA_ID":17793,"compounds":"H2O + L-alanyl-tRNA(Thr) = H(+) + L-alanine + tRNA(Thr)"}
{"X":20831,"RHEA_ID":17794,"compounds":"H2O + L-alanyl-tRNA(Thr) => H(+) + L-alanine + tRNA(Thr)"}
{"X":20832,"RHEA_ID":17795,"compounds":"H(+) + L-alanine + tRNA(Thr) => H2O + L-alanyl-tRNA(Thr)"}
{"X":20833,"RHEA_ID":17796,"compounds":"H2O + L-alanyl-tRNA(Thr) <=> H(+) + L-alanine + tRNA(Thr)"}
{"X":20834,"RHEA_ID":17797,"DIRECTION":"UN","MASTER_ID":17797,"ec":"2.4.1.29","compounds":"[(1->4)-beta-D-glucosyl](n) + GDP-alpha-D-glucose = [(1->4)-beta-D-glucosyl](n+1) + GDP + H(+)"}
{"X":20835,"RHEA_ID":17798,"DIRECTION":"LR","MASTER_ID":17797,"metacyc":"CELLULOSE-SYNTHASE-GDP-FORMING-RXN","compounds":"[(1->4)-beta-D-glucosyl](n) + GDP-alpha-D-glucose => [(1->4)-beta-D-glucosyl](n+1) + GDP + H(+)"}
{"X":20836,"RHEA_ID":17799,"compounds":"[(1->4)-beta-D-glucosyl](n+1) + GDP + H(+) => [(1->4)-beta-D-glucosyl](n) + GDP-alpha-D-glucose"}
{"X":20837,"RHEA_ID":28435,"DIRECTION":"LR","MASTER_ID":28434,"ecocyc":"MYRPALMTRAN-RXN","metacyc":"MYRPALMTRAN-RXN","compounds":"(9Z)-hexadecenoyl-(Kdo)2-lipid IVA + tetradecanoyl-[ACP] => ((9Z)-hexadecenoyl-tetradecanoyl)-(Kdo)2-lipid A + holo-[ACP]"}
{"X":20838,"RHEA_ID":17801,"DIRECTION":"UN","MASTER_ID":17801,"ec":"2.3.1.53","compounds":"acetyl-CoA + L-phenylalanine = CoA + H(+) + N-acetyl-L-phenylalanine"}
{"X":20839,"RHEA_ID":17802,"compounds":"acetyl-CoA + L-phenylalanine => CoA + H(+) + N-acetyl-L-phenylalanine"}
{"X":20840,"RHEA_ID":17803,"compounds":"CoA + H(+) + N-acetyl-L-phenylalanine => acetyl-CoA + L-phenylalanine"}
{"X":20841,"RHEA_ID":28439,"DIRECTION":"LR","MASTER_ID":28438,"ecocyc":"MYRISTOYLACYLTRAN-RXN","metacyc":"MYRISTOYLACYLTRAN-RXN","compounds":"dodecanoyl-(Kdo)2-lipid IVA + tetradecanoyl-[ACP] => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + holo-[ACP]"}
{"X":20842,"RHEA_ID":17805,"DIRECTION":"UN","MASTER_ID":17805,"ec":"3.2.2.9","compounds":"H2O + S-adenosyl-L-homocysteine = adenine + S-(5-deoxy-D-ribos-5-yl)-L-homocysteine"}
{"X":20843,"RHEA_ID":17806,"DIRECTION":"LR","MASTER_ID":17805,"ecocyc":"ADENOSYLHOMOCYSTEINE-NUCLEOSIDASE-RXN","metacyc":"ADENOSYLHOMOCYSTEINE-NUCLEOSIDASE-RXN","compounds":"H2O + S-adenosyl-L-homocysteine => adenine + S-(5-deoxy-D-ribos-5-yl)-L-homocysteine"}
{"X":20844,"RHEA_ID":17807,"compounds":"adenine + S-(5-deoxy-D-ribos-5-yl)-L-homocysteine => H2O + S-adenosyl-L-homocysteine"}
{"X":20845,"RHEA_ID":28443,"DIRECTION":"LR","MASTER_ID":28442,"ecocyc":"LAUROYLACYLTRAN-RXN","metacyc":"LAUROYLACYLTRAN-RXN","compounds":"alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + dodecanoyl-[ACP] => dodecanoyl-(Kdo)2-lipid IVA + holo-[ACP]"}
{"X":20846,"RHEA_ID":17809,"DIRECTION":"UN","MASTER_ID":17809,"ec":"2.1.1.11","compounds":"Mg-protoporphyrin IX + S-adenosyl-L-methionine = Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-homocysteine"}
{"X":20847,"RHEA_ID":17810,"DIRECTION":"LR","MASTER_ID":17809,"metacyc":"RXN-MG-PROTOPORPHYRIN-METHYLESTER-SYN","compounds":"Mg-protoporphyrin IX + S-adenosyl-L-methionine => Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-homocysteine"}
{"X":20848,"RHEA_ID":17811,"compounds":"Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-homocysteine => Mg-protoporphyrin IX + S-adenosyl-L-methionine"}
{"X":20849,"RHEA_ID":28447,"compounds":"1-deoxy-D-xylulose(in) => 1-deoxy-D-xylulose(out)"}
{"X":20850,"RHEA_ID":17813,"DIRECTION":"UN","MASTER_ID":17813,"ec":"1.1.1.58","compounds":"D-altronate + NAD(+) = H(+) + keto-D-tagaturonate + NADH"}
{"X":20851,"RHEA_ID":17814,"compounds":"D-altronate + NAD(+) => H(+) + keto-D-tagaturonate + NADH"}
{"X":20852,"RHEA_ID":17815,"compounds":"H(+) + keto-D-tagaturonate + NADH => D-altronate + NAD(+)"}
{"X":20853,"RHEA_ID":28451,"compounds":"N(6)-(D-psicosyl)-L-lysine(in) => N(6)-(D-psicosyl)-L-lysine(out)"}
{"X":20854,"RHEA_ID":17817,"DIRECTION":"UN","MASTER_ID":17817,"ec":"2.3.1.191","compounds":"(3R)-hydroxytetradecanoyl-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine = H(+) + holo-[ACP] + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine"}
{"X":20855,"RHEA_ID":17818,"DIRECTION":"LR","MASTER_ID":17817,"ecocyc":"UDPHYDROXYMYRGLUCOSAMNACETYLTRANS-RXN","metacyc":"UDPHYDROXYMYRGLUCOSAMNACETYLTRANS-RXN","compounds":"(3R)-hydroxytetradecanoyl-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine => H(+) + holo-[ACP] + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine"}
{"X":20856,"RHEA_ID":17819,"compounds":"H(+) + holo-[ACP] + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine => (3R)-hydroxytetradecanoyl-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine"}
{"X":20857,"RHEA_ID":17821,"DIRECTION":"UN","MASTER_ID":17821,"ec":"4.4.1.9","compounds":"hydrogen cyanide + L-cysteine = 3-cyano-L-alanine + H(+) + hydrogen sulfide"}
{"X":20858,"RHEA_ID":17822,"compounds":"hydrogen cyanide + L-cysteine => 3-cyano-L-alanine + H(+) + hydrogen sulfide"}
{"X":20859,"RHEA_ID":17823,"compounds":"3-cyano-L-alanine + H(+) + hydrogen sulfide => hydrogen cyanide + L-cysteine"}
{"X":20860,"RHEA_ID":28459,"compounds":"biotin(in) => biotin(out)"}
{"X":20861,"RHEA_ID":17825,"DIRECTION":"UN","MASTER_ID":17825,"ec":"2.7.1.1","compounds":"ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+)"}
{"X":20862,"RHEA_ID":17825,"DIRECTION":"UN","MASTER_ID":17825,"ec":"2.7.1.2","compounds":"ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+)"}
{"X":20863,"RHEA_ID":17826,"DIRECTION":"LR","MASTER_ID":17825,"ecocyc":"GLUCOKIN-RXN","metacyc":"GLUCOKIN-RXN","compounds":"ATP + D-glucose => ADP + D-glucose 6-phosphate + H(+)"}
{"X":20864,"RHEA_ID":17826,"DIRECTION":"LR","MASTER_ID":17825,"ecocyc":"GLUCOKIN-RXN","metacyc":"RXN-1685","compounds":"ATP + D-glucose => ADP + D-glucose 6-phosphate + H(+)"}
{"X":20865,"RHEA_ID":17827,"compounds":"ADP + D-glucose 6-phosphate + H(+) => ATP + D-glucose"}
{"X":20866,"RHEA_ID":28465,"compounds":"pyridoxal(in) <=> pyridoxal(out)"}
{"X":20867,"RHEA_ID":17829,"compounds":"A + CO + H2O = AH2 + CO2"}
{"X":20868,"RHEA_ID":17830,"compounds":"A + CO + H2O => AH2 + CO2"}
{"X":20869,"RHEA_ID":17831,"compounds":"AH2 + CO2 => A + CO + H2O"}
{"X":20870,"RHEA_ID":17833,"DIRECTION":"UN","MASTER_ID":17833,"ec":"2.1.1.97","compounds":"3-hydroxyanthranilate + S-adenosyl-L-methionine = 3-hydroxy-4-methylanthranilate + H(+) + S-adenosyl-L-homocysteine"}
{"X":20871,"RHEA_ID":17834,"DIRECTION":"LR","MASTER_ID":17833,"metacyc":"2.1.1.97-RXN","compounds":"3-hydroxyanthranilate + S-adenosyl-L-methionine => 3-hydroxy-4-methylanthranilate + H(+) + S-adenosyl-L-homocysteine"}
{"X":20872,"RHEA_ID":17835,"compounds":"3-hydroxy-4-methylanthranilate + H(+) + S-adenosyl-L-homocysteine => 3-hydroxyanthranilate + S-adenosyl-L-methionine"}
{"X":20873,"RHEA_ID":28473,"compounds":"pyridoxine(in) <=> pyridoxine(out)"}
{"X":20874,"RHEA_ID":17837,"DIRECTION":"UN","MASTER_ID":17837,"ec":"3.1.3.63","compounds":"2-carboxy-D-arabinitol 1-phosphate + H2O = 2-carboxy-D-arabinitol + phosphate"}
{"X":20875,"RHEA_ID":17838,"DIRECTION":"LR","MASTER_ID":17837,"metacyc":"2-CARBOXY-D-ARABINITOL-1-PHOSPHATASE-RXN","compounds":"2-carboxy-D-arabinitol 1-phosphate + H2O => 2-carboxy-D-arabinitol + phosphate"}
{"X":20876,"RHEA_ID":17839,"compounds":"2-carboxy-D-arabinitol + phosphate => 2-carboxy-D-arabinitol 1-phosphate + H2O"}
{"X":20877,"RHEA_ID":28477,"compounds":"D-glucarate(in) <=> D-glucarate(out)"}
{"X":20878,"RHEA_ID":17841,"DIRECTION":"UN","MASTER_ID":17841,"ec":"2.4.1.229","compounds":"[Skp1 protein]-trans-4-hydroxy-L-proline + UDP-N-acetyl-alpha-D-glucosamine = [Skp1 protein]-O-(N-acetyl-alpha-D-glucosaminyl)-trans-4-hydroxy-L-proline + H(+) + UDP"}
{"X":20879,"RHEA_ID":17842,"compounds":"[Skp1 protein]-trans-4-hydroxy-L-proline + UDP-N-acetyl-alpha-D-glucosamine => [Skp1 protein]-O-(N-acetyl-alpha-D-glucosaminyl)-trans-4-hydroxy-L-proline + H(+) + UDP"}
{"X":20880,"RHEA_ID":17843,"compounds":"[Skp1 protein]-O-(N-acetyl-alpha-D-glucosaminyl)-trans-4-hydroxy-L-proline + H(+) + UDP => [Skp1 protein]-trans-4-hydroxy-L-proline + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":20881,"RHEA_ID":17844,"DIRECTION":"BI","MASTER_ID":17841,"metacyc":"2.4.1.229-RXN","compounds":"[Skp1 protein]-trans-4-hydroxy-L-proline + UDP-N-acetyl-alpha-D-glucosamine <=> [Skp1 protein]-O-(N-acetyl-alpha-D-glucosaminyl)-trans-4-hydroxy-L-proline + H(+) + UDP"}
{"X":20882,"RHEA_ID":17845,"DIRECTION":"UN","MASTER_ID":17845,"ec":"1.1.1.193","compounds":"5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) = 5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH"}
{"X":20883,"RHEA_ID":17846,"compounds":"5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) => 5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH"}
{"X":20884,"RHEA_ID":17847,"DIRECTION":"RL","MASTER_ID":17845,"ecocyc":"RIBOFLAVINSYNREDUC-RXN","metacyc":"RIBOFLAVINSYNREDUC-RXN","compounds":"5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH => 5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+)"}
{"X":20885,"RHEA_ID":28485,"DIRECTION":"BI","MASTER_ID":28482,"ecocyc":"TRANS-RXN-9","compounds":"beta-nicotinamide D-ribonucleotide(in) <=> beta-nicotinamide D-ribonucleotide(out)"}
{"X":20886,"RHEA_ID":17849,"DIRECTION":"UN","MASTER_ID":17849,"ec":"4.2.1.55","compounds":"(3R)-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O"}
{"X":20887,"RHEA_ID":17850,"compounds":"(3R)-hydroxybutanoyl-CoA => (2E)-butenoyl-CoA + H2O"}
{"X":20888,"RHEA_ID":17851,"compounds":"(2E)-butenoyl-CoA + H2O => (3R)-hydroxybutanoyl-CoA"}
{"X":20889,"RHEA_ID":28488,"DIRECTION":"RL","MASTER_ID":28486,"ecocyc":"TRANS-RXN-8","reactome":"R-HSA-442368.2","compounds":"Fe(2+)(out) => Fe(2+)(in)"}
{"X":20890,"RHEA_ID":17853,"DIRECTION":"UN","MASTER_ID":17853,"ec":"1.1.3.11","compounds":"keto-L-sorbose + O2 = 5-dehydro-D-fructose + H2O2"}
{"X":20891,"RHEA_ID":17854,"DIRECTION":"LR","MASTER_ID":17853,"metacyc":"L-SORBOSE-OXIDASE-RXN","compounds":"keto-L-sorbose + O2 => 5-dehydro-D-fructose + H2O2"}
{"X":20892,"RHEA_ID":17855,"compounds":"5-dehydro-D-fructose + H2O2 => keto-L-sorbose + O2"}
{"X":20893,"RHEA_ID":28491,"compounds":"H(+)(in) + K(+)(in) => H(+)(out) + K(+)(out)"}
{"X":20894,"RHEA_ID":17857,"DIRECTION":"UN","MASTER_ID":17857,"ec":"1.14.14.57","compounds":"O2 + reduced [NADPH--hemoprotein reductase] + taurochenodeoxycholate = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taurohyocholate"}
{"X":20895,"RHEA_ID":17858,"DIRECTION":"LR","MASTER_ID":17857,"metacyc":"RXN-7976","compounds":"O2 + reduced [NADPH--hemoprotein reductase] + taurochenodeoxycholate => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taurohyocholate"}
{"X":20896,"RHEA_ID":17859,"compounds":"H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taurohyocholate => O2 + reduced [NADPH--hemoprotein reductase] + taurochenodeoxycholate"}
{"X":20897,"RHEA_ID":28495,"compounds":"a menaquinone + dimethyl sulfide + H2O => a menaquinol + dimethyl sulfoxide"}
{"X":20898,"RHEA_ID":17861,"DIRECTION":"UN","MASTER_ID":17861,"ec":"5.3.1.21","metacyc":"CORTICOSTEROID-SIDE-CHAIN-ISOMERASE-RXN","compounds":"21-hydroxyprogesterone = 20-hydroxy-3-oxopregn-4-en-21-al"}
{"X":20899,"RHEA_ID":17862,"compounds":"21-hydroxyprogesterone => 20-hydroxy-3-oxopregn-4-en-21-al"}
{"X":20900,"RHEA_ID":17863,"compounds":"20-hydroxy-3-oxopregn-4-en-21-al => 21-hydroxyprogesterone"}
{"X":20901,"RHEA_ID":28499,"DIRECTION":"LR","MASTER_ID":28498,"metacyc":"RXN-6581","compounds":"formaldehyde + mycothiol => S-(hydroxymethyl)mycothiol"}
{"X":20902,"RHEA_ID":17865,"DIRECTION":"UN","MASTER_ID":17865,"ec":"1.5.1.34","compounds":"5,6,7,8-tetrahydropteridine + NADP(+) = 6,7-dihydropteridine + H(+) + NADPH"}
{"X":20903,"RHEA_ID":17866,"compounds":"5,6,7,8-tetrahydropteridine + NADP(+) => 6,7-dihydropteridine + H(+) + NADPH"}
{"X":20904,"RHEA_ID":17867,"DIRECTION":"RL","MASTER_ID":17865,"ecocyc":"1.5.1.34-RXN","metacyc":"1.5.1.34-RXN","compounds":"6,7-dihydropteridine + H(+) + NADPH => 5,6,7,8-tetrahydropteridine + NADP(+)"}
{"X":20905,"RHEA_ID":28503,"DIRECTION":"LR","MASTER_ID":28502,"metacyc":"1.2.1.66-RXN","compounds":"NAD(+) + S-(hydroxymethyl)mycothiol => H(+) + NADH + S-formylmycothiol"}
{"X":20906,"RHEA_ID":17869,"DIRECTION":"UN","MASTER_ID":17869,"ec":"1.5.1.34","compounds":"5,6,7,8-tetrahydropteridine + NAD(+) = 6,7-dihydropteridine + H(+) + NADH"}
{"X":20907,"RHEA_ID":17870,"compounds":"5,6,7,8-tetrahydropteridine + NAD(+) => 6,7-dihydropteridine + H(+) + NADH"}
{"X":20908,"RHEA_ID":17871,"DIRECTION":"RL","MASTER_ID":17869,"ecocyc":"1.5.1.34-RXN","metacyc":"1.5.1.34-RXN","compounds":"6,7-dihydropteridine + H(+) + NADH => 5,6,7,8-tetrahydropteridine + NAD(+)"}
{"X":20909,"RHEA_ID":28507,"compounds":"alpha-Kdo-(2->6)-lipid IVA + ATP => 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA + ADP + H(+)"}
{"X":20910,"RHEA_ID":17873,"DIRECTION":"UN","MASTER_ID":17873,"ec":"7.6.2.8","compounds":"ATP + cob(III)alamin(out) + H2O = ADP + cob(III)alamin(in) + H(+) + phosphate"}
{"X":20911,"RHEA_ID":17874,"DIRECTION":"LR","MASTER_ID":17873,"ecocyc":"ABC-5-RXN","metacyc":"3.6.3.33-RXN","compounds":"ATP + cob(III)alamin(out) + H2O => ADP + cob(III)alamin(in) + H(+) + phosphate"}
{"X":20912,"RHEA_ID":17875,"compounds":"ADP + cob(III)alamin(in) + H(+) + phosphate => ATP + cob(III)alamin(out) + H2O"}
{"X":20913,"RHEA_ID":17876,"compounds":"ATP + cob(III)alamin(out) + H2O <=> ADP + cob(III)alamin(in) + H(+) + phosphate"}
{"X":20914,"RHEA_ID":17877,"DIRECTION":"UN","MASTER_ID":17877,"ec":"2.1.1.6","compounds":"a catechol + S-adenosyl-L-methionine = a guaiacol + H(+) + S-adenosyl-L-homocysteine"}
{"X":20915,"RHEA_ID":17878,"DIRECTION":"LR","MASTER_ID":17877,"metacyc":"CATECHOL-O-METHYLTRANSFERASE-RXN","compounds":"a catechol + S-adenosyl-L-methionine => a guaiacol + H(+) + S-adenosyl-L-homocysteine"}
{"X":20916,"RHEA_ID":17879,"compounds":"a guaiacol + H(+) + S-adenosyl-L-homocysteine => a catechol + S-adenosyl-L-methionine"}
{"X":20917,"RHEA_ID":28515,"DIRECTION":"LR","MASTER_ID":28514,"ecocyc":"LCARNCOALIG-RXN","metacyc":"LCARNCOALIG-RXN","compounds":"(R)-carnitine + ATP + CoA => (R)-carnitinyl-CoA + AMP + diphosphate"}
{"X":20918,"RHEA_ID":17881,"DIRECTION":"UN","MASTER_ID":17881,"ec":"3.10.1.1","compounds":"H2O + N-sulfo-D-glucosamine = D-glucosamine + sulfate"}
{"X":20919,"RHEA_ID":17882,"DIRECTION":"LR","MASTER_ID":17881,"metacyc":"N-SULFOGLUCOSAMINE-SULFOHYDROLASE-RXN","compounds":"H2O + N-sulfo-D-glucosamine => D-glucosamine + sulfate"}
{"X":20920,"RHEA_ID":17883,"compounds":"D-glucosamine + sulfate => H2O + N-sulfo-D-glucosamine"}
{"X":20921,"RHEA_ID":28519,"DIRECTION":"LR","MASTER_ID":28518,"ecocyc":"RXN0-4361","metacyc":"RXN0-4361","compounds":"D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O => D-glycero-beta-D-manno-heptose 1-phosphate + phosphate"}
{"X":20922,"RHEA_ID":17885,"DIRECTION":"UN","MASTER_ID":17885,"ec":"4.2.1.112","compounds":"acetaldehyde = acetylene + H2O"}
{"X":20923,"RHEA_ID":17886,"compounds":"acetaldehyde => acetylene + H2O"}
{"X":20924,"RHEA_ID":17887,"DIRECTION":"RL","MASTER_ID":17885,"metacyc":"R141-RXN","compounds":"acetylene + H2O => acetaldehyde"}
{"X":20925,"RHEA_ID":17889,"DIRECTION":"UN","MASTER_ID":17889,"ec":"4.2.3.2","compounds":"H2O + phosphoethanolamine = acetaldehyde + NH4(+) + phosphate"}
{"X":20926,"RHEA_ID":17890,"DIRECTION":"LR","MASTER_ID":17889,"reactome":"R-HSA-5696415.2","compounds":"H2O + phosphoethanolamine => acetaldehyde + NH4(+) + phosphate"}
{"X":20927,"RHEA_ID":17891,"compounds":"acetaldehyde + NH4(+) + phosphate => H2O + phosphoethanolamine"}
{"X":20928,"RHEA_ID":17897,"DIRECTION":"UN","MASTER_ID":17897,"ec":"1.17.99.2","compounds":"A + ethylbenzene + H2O = (S)-1-phenylethanol + AH2"}
{"X":20929,"RHEA_ID":17898,"DIRECTION":"LR","MASTER_ID":17897,"metacyc":"RXN-1301","compounds":"A + ethylbenzene + H2O => (S)-1-phenylethanol + AH2"}
{"X":20930,"RHEA_ID":17899,"compounds":"(S)-1-phenylethanol + AH2 => A + ethylbenzene + H2O"}
{"X":20931,"RHEA_ID":28531,"DIRECTION":"LR","MASTER_ID":28530,"ecocyc":"XMPXAN-RXN","metacyc":"XMPXAN-RXN","compounds":"H2O + XMP => phosphate + xanthosine"}
{"X":20932,"RHEA_ID":17901,"DIRECTION":"UN","MASTER_ID":17901,"ec":"2.1.1.70","compounds":"S-adenosyl-L-methionine + xanthotoxol = H(+) + S-adenosyl-L-homocysteine + xanthotoxin"}
{"X":20933,"RHEA_ID":17902,"DIRECTION":"LR","MASTER_ID":17901,"metacyc":"RXN-12092","compounds":"S-adenosyl-L-methionine + xanthotoxol => H(+) + S-adenosyl-L-homocysteine + xanthotoxin"}
{"X":20934,"RHEA_ID":17903,"compounds":"H(+) + S-adenosyl-L-homocysteine + xanthotoxin => S-adenosyl-L-methionine + xanthotoxol"}
{"X":20935,"RHEA_ID":28535,"DIRECTION":"LR","MASTER_ID":28534,"ecocyc":"RXN0-5107","metacyc":"RXN0-5107","compounds":"dTTP + H2O => diphosphate + dTMP + H(+)"}
{"X":20936,"RHEA_ID":17905,"DIRECTION":"UN","MASTER_ID":17905,"ec":"1.1.1.29","compounds":"(R)-glycerate + NAD(+) = 3-hydroxypyruvate + H(+) + NADH"}
{"X":20937,"RHEA_ID":17905,"DIRECTION":"UN","MASTER_ID":17905,"ec":"1.1.1.81","compounds":"(R)-glycerate + NAD(+) = 3-hydroxypyruvate + H(+) + NADH"}
{"X":20938,"RHEA_ID":17906,"compounds":"(R)-glycerate + NAD(+) => 3-hydroxypyruvate + H(+) + NADH"}
{"X":20939,"RHEA_ID":17907,"DIRECTION":"RL","MASTER_ID":17905,"metacyc":"GLYCERATE-DEHYDROGENASE-RXN","compounds":"3-hydroxypyruvate + H(+) + NADH => (R)-glycerate + NAD(+)"}
{"X":20940,"RHEA_ID":28540,"compounds":"ADP + H(+) + L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A => ADP-L-glycero-beta-D-manno-heptose + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A"}
{"X":20941,"RHEA_ID":17909,"DIRECTION":"UN","MASTER_ID":17909,"ec":"4.1.2.36","compounds":"(S)-lactate = acetaldehyde + formate"}
{"X":20942,"RHEA_ID":17910,"compounds":"(S)-lactate => acetaldehyde + formate"}
{"X":20943,"RHEA_ID":17911,"compounds":"acetaldehyde + formate => (S)-lactate"}
{"X":20944,"RHEA_ID":17913,"DIRECTION":"UN","MASTER_ID":17913,"ec":"1.7.1.1","compounds":"H2O + NAD(+) + nitrite = H(+) + NADH + nitrate"}
{"X":20945,"RHEA_ID":17913,"DIRECTION":"UN","MASTER_ID":17913,"ec":"1.7.1.2","compounds":"H2O + NAD(+) + nitrite = H(+) + NADH + nitrate"}
{"X":20946,"RHEA_ID":17914,"compounds":"H2O + NAD(+) + nitrite => H(+) + NADH + nitrate"}
{"X":20947,"RHEA_ID":17915,"DIRECTION":"RL","MASTER_ID":17913,"metacyc":"NITRATE-REDUCTASE-NADH-RXN","compounds":"H(+) + NADH + nitrate => H2O + NAD(+) + nitrite"}
{"X":20948,"RHEA_ID":17917,"DIRECTION":"UN","MASTER_ID":17917,"ec":"2.3.2.15","compounds":"[Glu(-Cys)](n)-Gly + glutathione + H(+) = [Glu(-Cys)](n+1)-Gly + glycine"}
{"X":20949,"RHEA_ID":17918,"DIRECTION":"LR","MASTER_ID":17917,"metacyc":"2.3.2.15-RXN","compounds":"[Glu(-Cys)](n)-Gly + glutathione + H(+) => [Glu(-Cys)](n+1)-Gly + glycine"}
{"X":20950,"RHEA_ID":17919,"compounds":"[Glu(-Cys)](n+1)-Gly + glycine => [Glu(-Cys)](n)-Gly + glutathione + H(+)"}
{"X":20951,"RHEA_ID":17921,"DIRECTION":"UN","MASTER_ID":17921,"ec":"1.1.1.11","compounds":"D-arabinitol + NAD(+) = D-xylulose + H(+) + NADH"}
{"X":20952,"RHEA_ID":17922,"DIRECTION":"LR","MASTER_ID":17921,"metacyc":"D-ARABINITOL-4-DEHYDROGENASE-RXN","compounds":"D-arabinitol + NAD(+) => D-xylulose + H(+) + NADH"}
{"X":20953,"RHEA_ID":17923,"compounds":"D-xylulose + H(+) + NADH => D-arabinitol + NAD(+)"}
{"X":20954,"RHEA_ID":28556,"compounds":"D-mannose + phosphate => D-mannose 6-phosphate + H2O"}
{"X":20955,"RHEA_ID":17925,"DIRECTION":"UN","MASTER_ID":17925,"ec":"1.1.1.376","metacyc":"L-ARABINOSE-1-DEHYDROGENASE-RXN","compounds":"L-arabinofuranose + NAD(+) = H(+) + L-arabinono-1,4-lactone + NADH"}
{"X":20956,"RHEA_ID":17925,"DIRECTION":"UN","MASTER_ID":17925,"ec":"1.1.1.46","metacyc":"L-ARABINOSE-1-DEHYDROGENASE-RXN","compounds":"L-arabinofuranose + NAD(+) = H(+) + L-arabinono-1,4-lactone + NADH"}
{"X":20957,"RHEA_ID":17925,"DIRECTION":"UN","MASTER_ID":17925,"ec":"1.1.1.359","metacyc":"L-ARABINOSE-1-DEHYDROGENASE-RXN","compounds":"L-arabinofuranose + NAD(+) = H(+) + L-arabinono-1,4-lactone + NADH"}
{"X":20958,"RHEA_ID":17926,"DIRECTION":"LR","MASTER_ID":17925,"metacyc":"RXN-8774","compounds":"L-arabinofuranose + NAD(+) => H(+) + L-arabinono-1,4-lactone + NADH"}
{"X":20959,"RHEA_ID":17927,"compounds":"H(+) + L-arabinono-1,4-lactone + NADH => L-arabinofuranose + NAD(+)"}
{"X":20960,"RHEA_ID":28562,"compounds":"D-alanine + pyridoxal 5'-phosphate = pyridoxamine 5'-phosphate + pyruvate"}
{"X":20961,"RHEA_ID":17929,"DIRECTION":"UN","MASTER_ID":17929,"ec":"2.7.1.138","compounds":"an N-acylsphing-4-enine + ATP = ADP + H(+) + N-acylsphing-4-enine 1-phosphate"}
{"X":20962,"RHEA_ID":17930,"compounds":"an N-acylsphing-4-enine + ATP => ADP + H(+) + N-acylsphing-4-enine 1-phosphate"}
{"X":20963,"RHEA_ID":17931,"compounds":"ADP + H(+) + N-acylsphing-4-enine 1-phosphate => an N-acylsphing-4-enine + ATP"}
{"X":20964,"RHEA_ID":28566,"compounds":"3 2,3-dihydroxybenzoyl-5'-AMP + 3 L-seryl-5'-AMP = 6 AMP + enterobactin + 7 H(+)"}
{"X":20965,"RHEA_ID":17933,"DIRECTION":"UN","MASTER_ID":17933,"ec":"2.1.1.150","compounds":"a 7-hydroxyisoflavone + S-adenosyl-L-methionine = a 7-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine"}
{"X":20966,"RHEA_ID":17934,"DIRECTION":"LR","MASTER_ID":17933,"metacyc":"RXN-6241","compounds":"a 7-hydroxyisoflavone + S-adenosyl-L-methionine => a 7-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine"}
{"X":20967,"RHEA_ID":17935,"compounds":"a 7-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine => a 7-hydroxyisoflavone + S-adenosyl-L-methionine"}
{"X":20968,"RHEA_ID":28570,"compounds":"ATP + L-serine = diphosphate + L-seryl-5'-AMP"}
{"X":20969,"RHEA_ID":17937,"DIRECTION":"UN","MASTER_ID":17937,"ec":"4.2.3.3","compounds":"dihydroxyacetone phosphate = methylglyoxal + phosphate"}
{"X":20970,"RHEA_ID":17938,"DIRECTION":"LR","MASTER_ID":17937,"ecocyc":"METHGLYSYN-RXN","macie":"M0085","metacyc":"METHGLYSYN-RXN","compounds":"dihydroxyacetone phosphate => methylglyoxal + phosphate"}
{"X":20971,"RHEA_ID":17939,"compounds":"methylglyoxal + phosphate => dihydroxyacetone phosphate"}
{"X":20972,"RHEA_ID":17941,"DIRECTION":"UN","MASTER_ID":17941,"ec":"4.2.1.99","compounds":"(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O"}
{"X":20973,"RHEA_ID":17942,"compounds":"(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate => 2-methyl-cis-aconitate + H2O"}
{"X":20974,"RHEA_ID":17943,"compounds":"2-methyl-cis-aconitate + H2O => (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate"}
{"X":20975,"RHEA_ID":28578,"compounds":"Co(2+)(in) = Co(2+)(out)"}
{"X":20976,"RHEA_ID":17945,"DIRECTION":"UN","MASTER_ID":17945,"ec":"1.14.14.51","compounds":"(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1S,5R)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":20977,"RHEA_ID":17946,"DIRECTION":"LR","MASTER_ID":17945,"metacyc":"--LIMONENE-6-MONOOXYGENASE-RXN","compounds":"(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] => (1S,5R)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":20978,"RHEA_ID":17947,"compounds":"(1S,5R)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":20979,"RHEA_ID":28582,"DIRECTION":"UN","MASTER_ID":28582,"ec":"2.7.4.6","compounds":"ATP + dUDP = ADP + dUTP"}
{"X":20980,"RHEA_ID":17949,"DIRECTION":"UN","MASTER_ID":17949,"ec":"1.13.11.47","compounds":"3-hydroxy-1H-quinolin-4-one + O2 = CO + H(+) + N-formylanthranilate"}
{"X":20981,"RHEA_ID":17950,"DIRECTION":"LR","MASTER_ID":17949,"metacyc":"1.13.11.47-RXN","compounds":"3-hydroxy-1H-quinolin-4-one + O2 => CO + H(+) + N-formylanthranilate"}
{"X":20982,"RHEA_ID":17951,"compounds":"CO + H(+) + N-formylanthranilate => 3-hydroxy-1H-quinolin-4-one + O2"}
{"X":20983,"RHEA_ID":28598,"compounds":"H2O + N-acetyl-L-lysine = acetate + L-lysine"}
{"X":20984,"RHEA_ID":17953,"DIRECTION":"UN","MASTER_ID":17953,"ec":"1.13.11.6","compounds":"3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde"}
{"X":20985,"RHEA_ID":17954,"compounds":"3-hydroxyanthranilate + O2 => (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde"}
{"X":20986,"RHEA_ID":17955,"compounds":"(2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde => 3-hydroxyanthranilate + O2"}
{"X":20987,"RHEA_ID":28602,"DIRECTION":"UN","MASTER_ID":28602,"ec":"1.14.14.39","compounds":"L-isoleucine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (1E,2S)-2-methylbutanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":20988,"RHEA_ID":17957,"DIRECTION":"UN","MASTER_ID":17957,"ec":"4.2.1.27","compounds":"3-oxopropanoate = H2O + propynoate"}
{"X":20989,"RHEA_ID":17958,"compounds":"3-oxopropanoate => H2O + propynoate"}
{"X":20990,"RHEA_ID":17959,"DIRECTION":"RL","MASTER_ID":17957,"metacyc":"MALONATE-SEMIALDEHYDE-DEHYDRATASE-RXN","compounds":"H2O + propynoate => 3-oxopropanoate"}
{"X":20991,"RHEA_ID":17961,"compounds":"(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = H2O + leukotriene A4"}
{"X":20992,"RHEA_ID":17962,"DIRECTION":"LR","MASTER_ID":17961,"metacyc":"RXN-8647","reactome":"R-HSA-266051.2","compounds":"(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate => H2O + leukotriene A4"}
{"X":20993,"RHEA_ID":17963,"compounds":"H2O + leukotriene A4 => (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate"}
{"X":20994,"RHEA_ID":28610,"DIRECTION":"UN","MASTER_ID":28610,"ec":"3.6.1.66","compounds":"H2O + XTP = diphosphate + H(+) + XMP"}
{"X":20995,"RHEA_ID":17965,"compounds":"(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + H(+) = (8Z,11Z,14Z)-heptadecatrienal + CO2 + H2O"}
{"X":20996,"RHEA_ID":17966,"compounds":"(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + H(+) => (8Z,11Z,14Z)-heptadecatrienal + CO2 + H2O"}
{"X":20997,"RHEA_ID":17967,"compounds":"(8Z,11Z,14Z)-heptadecatrienal + CO2 + H2O => (R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + H(+)"}
{"X":20998,"RHEA_ID":17968,"compounds":"(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + H(+) <=> (8Z,11Z,14Z)-heptadecatrienal + CO2 + H2O"}
{"X":20999,"RHEA_ID":17969,"DIRECTION":"UN","MASTER_ID":17969,"ec":"6.3.2.7","compounds":"ATP + L-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine"}
{"X":21000,"RHEA_ID":17970,"DIRECTION":"LR","MASTER_ID":17969,"metacyc":"6.3.2.7-RXN","compounds":"ATP + L-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine"}
{"X":21001,"RHEA_ID":17971,"compounds":"ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine => ATP + L-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate"}
{"X":21002,"RHEA_ID":28617,"compounds":"(1Z,2S)-2-methylbutanal oxime <=> (2S)-2-methylbutanenitrile + H2O"}
{"X":21003,"RHEA_ID":17973,"DIRECTION":"UN","MASTER_ID":17973,"ec":"2.4.2.8","compounds":"diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine"}
{"X":21004,"RHEA_ID":17974,"compounds":"diphosphate + IMP => 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine"}
{"X":21005,"RHEA_ID":17975,"DIRECTION":"RL","MASTER_ID":17973,"ecocyc":"HYPOXANPRIBOSYLTRAN-RXN","metacyc":"HYPOXANPRIBOSYLTRAN-RXN","compounds":"5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine => diphosphate + IMP"}
{"X":21006,"RHEA_ID":28621,"compounds":"2-methylbutyronitrile + H(+) + NADPH + O2 <=> 2-hydroxy-2-methylbutanenitrile + H2O + NADP(+)"}
{"X":21007,"RHEA_ID":17977,"DIRECTION":"UN","MASTER_ID":17977,"ec":"1.1.1.192","compounds":"a long-chain primary fatty alcohol + H2O + 2 NAD(+) = a long-chain fatty acid + 3 H(+) + 2 NADH"}
{"X":21008,"RHEA_ID":17978,"compounds":"a long-chain primary fatty alcohol + H2O + 2 NAD(+) => a long-chain fatty acid + 3 H(+) + 2 NADH"}
{"X":21009,"RHEA_ID":17979,"compounds":"a long-chain fatty acid + 3 H(+) + 2 NADH => a long-chain primary fatty alcohol + H2O + 2 NAD(+)"}
{"X":21010,"RHEA_ID":17981,"compounds":"4,5alpha-dihydrocortisone + NADP(+) = cortisone + H(+) + NADPH"}
{"X":21011,"RHEA_ID":17982,"compounds":"4,5alpha-dihydrocortisone + NADP(+) => cortisone + H(+) + NADPH"}
{"X":21012,"RHEA_ID":17983,"DIRECTION":"RL","MASTER_ID":17981,"metacyc":"CORTISONE-ALPHA-REDUCTASE-RXN","compounds":"cortisone + H(+) + NADPH => 4,5alpha-dihydrocortisone + NADP(+)"}
{"X":21013,"RHEA_ID":28629,"compounds":"H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + solavetivone => O2 + reduced [NADPH--hemoprotein reductase] + solavetivol"}
{"X":21014,"RHEA_ID":17985,"DIRECTION":"UN","MASTER_ID":17985,"ec":"1.2.1.47","compounds":"4-(trimethylamino)butanal + H2O + NAD(+) = 4-(trimethylamino)butanoate + 2 H(+) + NADH"}
{"X":21015,"RHEA_ID":17986,"DIRECTION":"LR","MASTER_ID":17985,"metacyc":"1.2.1.47-RXN","reactome":"R-HSA-71260.4","compounds":"4-(trimethylamino)butanal + H2O + NAD(+) => 4-(trimethylamino)butanoate + 2 H(+) + NADH"}
{"X":21016,"RHEA_ID":17987,"compounds":"4-(trimethylamino)butanoate + 2 H(+) + NADH => 4-(trimethylamino)butanal + H2O + NAD(+)"}
{"X":21017,"RHEA_ID":28633,"compounds":"2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-galactose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate"}
{"X":21018,"RHEA_ID":17989,"DIRECTION":"UN","MASTER_ID":17989,"ec":"2.7.11.1","compounds":"ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]"}
{"X":21019,"RHEA_ID":17989,"DIRECTION":"UN","MASTER_ID":17989,"ec":"2.7.11.12","compounds":"ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]"}
{"X":21020,"RHEA_ID":17989,"DIRECTION":"UN","MASTER_ID":17989,"ec":"2.7.11.22","compounds":"ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]"}
{"X":21021,"RHEA_ID":17989,"DIRECTION":"UN","MASTER_ID":17989,"ec":"2.7.11.21","compounds":"ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]"}
{"X":21022,"RHEA_ID":17989,"DIRECTION":"UN","MASTER_ID":17989,"ec":"2.7.11.13","compounds":"ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]"}
{"X":21023,"RHEA_ID":17989,"DIRECTION":"UN","MASTER_ID":17989,"ec":"2.7.12.2","compounds":"ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]"}
{"X":21024,"RHEA_ID":17989,"DIRECTION":"UN","MASTER_ID":17989,"ec":"2.7.11.11","compounds":"ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]"}
{"X":21025,"RHEA_ID":17989,"DIRECTION":"UN","MASTER_ID":17989,"ec":"2.7.11.24","compounds":"ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]"}
{"X":21026,"RHEA_ID":17989,"DIRECTION":"UN","MASTER_ID":17989,"ec":"2.7.11.25","compounds":"ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]"}
{"X":21027,"RHEA_ID":17989,"DIRECTION":"UN","MASTER_ID":17989,"ec":"2.7.12.1","compounds":"ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]"}
{"X":21028,"RHEA_ID":17989,"DIRECTION":"UN","MASTER_ID":17989,"ec":"2.7.11.17","compounds":"ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]"}
{"X":21029,"RHEA_ID":17990,"DIRECTION":"LR","MASTER_ID":17989,"ecocyc":"PROTEIN-KINASE-RXN","metacyc":"PROTEIN-KINASE-RXN","compounds":"ATP + L-seryl-[protein] => ADP + H(+) + O-phospho-L-seryl-[protein]"}
{"X":21030,"RHEA_ID":17991,"compounds":"ADP + H(+) + O-phospho-L-seryl-[protein] => ATP + L-seryl-[protein]"}
{"X":21031,"RHEA_ID":28647,"DIRECTION":"UN","MASTER_ID":28647,"ec":"6.4.1.8","compounds":"acetophenone + 2 ATP + H2O + hydrogencarbonate = 3-oxo-3-phenylpropanoate + 2 ADP + 2 H(+) + 2 phosphate"}
{"X":21032,"RHEA_ID":17993,"DIRECTION":"UN","MASTER_ID":17993,"ec":"6.3.2.23","compounds":"ATP + beta-alanine + L-gamma-glutamyl-L-cysteine = ADP + gamma-L-glutamyl-L-cysteinyl-beta-alanine + H(+) + phosphate"}
{"X":21033,"RHEA_ID":17994,"DIRECTION":"LR","MASTER_ID":17993,"metacyc":"HOMOGLUTATHIONE-SYNTHASE-RXN","compounds":"ATP + beta-alanine + L-gamma-glutamyl-L-cysteine => ADP + gamma-L-glutamyl-L-cysteinyl-beta-alanine + H(+) + phosphate"}
{"X":21034,"RHEA_ID":17995,"compounds":"ADP + gamma-L-glutamyl-L-cysteinyl-beta-alanine + H(+) + phosphate => ATP + beta-alanine + L-gamma-glutamyl-L-cysteine"}
{"X":21035,"RHEA_ID":28651,"DIRECTION":"UN","MASTER_ID":28651,"ec":"1.1.3.28","compounds":"inosine + O2 = 9-riburonosylhypoxanthine + H(+) + H2O"}
{"X":21036,"RHEA_ID":17997,"DIRECTION":"UN","MASTER_ID":17997,"ec":"2.1.1.151","compounds":"Co-precorrin-2 + S-adenosyl-L-methionine = Co-precorrin-3 + H(+) + S-adenosyl-L-homocysteine"}
{"X":21037,"RHEA_ID":17998,"DIRECTION":"LR","MASTER_ID":17997,"metacyc":"RXN-8760","compounds":"Co-precorrin-2 + S-adenosyl-L-methionine => Co-precorrin-3 + H(+) + S-adenosyl-L-homocysteine"}
{"X":21038,"RHEA_ID":17999,"compounds":"Co-precorrin-3 + H(+) + S-adenosyl-L-homocysteine => Co-precorrin-2 + S-adenosyl-L-methionine"}
{"X":21039,"RHEA_ID":28655,"compounds":"glutathione S,S-dioxide + H2O = glutathione + H(+) + sulfite"}
{"X":21040,"RHEA_ID":18001,"DIRECTION":"UN","MASTER_ID":18001,"ec":"3.1.1.52","compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a carboxylate + H(+)"}
{"X":21041,"RHEA_ID":18002,"DIRECTION":"LR","MASTER_ID":18001,"metacyc":"PHOSPHATIDYLINOSITOL-DEACYLASE-RXN","compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a carboxylate + H(+)"}
{"X":21042,"RHEA_ID":18003,"compounds":"a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a carboxylate + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O"}
{"X":21043,"RHEA_ID":18005,"DIRECTION":"UN","MASTER_ID":18005,"ec":"1.1.1.162","compounds":"D-threitol + NADP(+) = D-erythrulose + H(+) + NADPH"}
{"X":21044,"RHEA_ID":18006,"compounds":"D-threitol + NADP(+) => D-erythrulose + H(+) + NADPH"}
{"X":21045,"RHEA_ID":18007,"compounds":"D-erythrulose + H(+) + NADPH => D-threitol + NADP(+)"}
{"X":21046,"RHEA_ID":28663,"compounds":"H2O + melibiose = alpha-D-galactose + beta-D-glucose"}
{"X":21047,"RHEA_ID":18009,"compounds":"glutaryl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-glutaryl-L-lysyl-[protein]"}
{"X":21048,"RHEA_ID":18010,"compounds":"glutaryl-CoA + L-lysyl-[protein] => CoA + H(+) + N(6)-glutaryl-L-lysyl-[protein]"}
{"X":21049,"RHEA_ID":18011,"compounds":"CoA + H(+) + N(6)-glutaryl-L-lysyl-[protein] => glutaryl-CoA + L-lysyl-[protein]"}
{"X":21050,"RHEA_ID":18012,"compounds":"glutaryl-CoA + L-lysyl-[protein] <=> CoA + H(+) + N(6)-glutaryl-L-lysyl-[protein]"}
{"X":21051,"RHEA_ID":18013,"DIRECTION":"UN","MASTER_ID":18013,"ec":"3.5.1.65","metacyc":"THEANINE-HYDROLASE-RXN","compounds":"H2O + N(5)-ethyl-L-glutamine = ethylamine + L-glutamate"}
{"X":21052,"RHEA_ID":18014,"compounds":"H2O + N(5)-ethyl-L-glutamine => ethylamine + L-glutamate"}
{"X":21053,"RHEA_ID":18015,"compounds":"ethylamine + L-glutamate => H2O + N(5)-ethyl-L-glutamine"}
{"X":21054,"RHEA_ID":28671,"DIRECTION":"UN","MASTER_ID":28671,"ec":"2.5.1.17","compounds":"2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate"}
{"X":21055,"RHEA_ID":18017,"DIRECTION":"UN","MASTER_ID":18017,"ec":"4.1.1.74","compounds":"H(+) + indole-3-pyruvate = CO2 + indole-3-acetaldehyde"}
{"X":21056,"RHEA_ID":18018,"DIRECTION":"LR","MASTER_ID":18017,"metacyc":"4.1.1.74-RXN","compounds":"H(+) + indole-3-pyruvate => CO2 + indole-3-acetaldehyde"}
{"X":21057,"RHEA_ID":18019,"compounds":"CO2 + indole-3-acetaldehyde => H(+) + indole-3-pyruvate"}
{"X":21058,"RHEA_ID":28675,"compounds":"alpha-D-galactose = beta-D-galactose"}
{"X":21059,"RHEA_ID":18021,"DIRECTION":"UN","MASTER_ID":18021,"ec":"2.4.99.2","compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)) = CMP + ganglioside GD1a (18:1(4E)) + H(+)"}
{"X":21060,"RHEA_ID":18022,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)) => CMP + ganglioside GD1a (18:1(4E)) + H(+)"}
{"X":21061,"RHEA_ID":18023,"compounds":"CMP + ganglioside GD1a (18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E))"}
{"X":21062,"RHEA_ID":28679,"DIRECTION":"UN","MASTER_ID":28679,"ec":"2.1.1.64","compounds":"3-demethylubiquinol-8 + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + ubiquinol-8"}
{"X":21063,"RHEA_ID":18029,"DIRECTION":"UN","MASTER_ID":18029,"ec":"6.3.4.16","compounds":"2 ATP + hydrogencarbonate + NH4(+) = 2 ADP + carbamoyl phosphate + 2 H(+) + phosphate"}
{"X":21064,"RHEA_ID":18030,"DIRECTION":"LR","MASTER_ID":18029,"metacyc":"RXN-13202","reactome":"R-HSA-70555.4","compounds":"2 ATP + hydrogencarbonate + NH4(+) => 2 ADP + carbamoyl phosphate + 2 H(+) + phosphate"}
{"X":21065,"RHEA_ID":18031,"compounds":"2 ADP + carbamoyl phosphate + 2 H(+) + phosphate => 2 ATP + hydrogencarbonate + NH4(+)"}
{"X":21066,"RHEA_ID":28683,"compounds":"L-aspartate + ubiquinone-8 = iminosuccinate + ubiquinol-8"}
{"X":21067,"RHEA_ID":18033,"DIRECTION":"UN","MASTER_ID":18033,"ec":"1.14.14.92","compounds":"benzoate + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxybenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":21068,"RHEA_ID":18034,"compounds":"benzoate + O2 + reduced [NADPH--hemoprotein reductase] => 4-hydroxybenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":21069,"RHEA_ID":18035,"compounds":"4-hydroxybenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => benzoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":21070,"RHEA_ID":28687,"DIRECTION":"UN","MASTER_ID":28687,"ec":"1.3.5.2","compounds":"(S)-dihydroorotate + ubiquinone-8 = orotate + ubiquinol-8"}
{"X":21071,"RHEA_ID":18037,"DIRECTION":"UN","MASTER_ID":18037,"ec":"3.5.3.12","compounds":"agmatine + H2O = N-carbamoylputrescine + NH4(+)"}
{"X":21072,"RHEA_ID":18038,"compounds":"agmatine + H2O => N-carbamoylputrescine + NH4(+)"}
{"X":21073,"RHEA_ID":18039,"compounds":"N-carbamoylputrescine + NH4(+) => agmatine + H2O"}
{"X":21074,"RHEA_ID":28691,"DIRECTION":"UN","MASTER_ID":28691,"ec":"1.3.5.2","compounds":"(S)-dihydroorotate + a ubiquinone = a ubiquinol + orotate"}
{"X":21075,"RHEA_ID":18041,"DIRECTION":"UN","MASTER_ID":18041,"ec":"1.7.7.1","compounds":"2 H2O + NH4(+) + 6 oxidized [2Fe-2S]-[ferredoxin] = 8 H(+) + nitrite + 6 reduced [2Fe-2S]-[ferredoxin]"}
{"X":21076,"RHEA_ID":18042,"compounds":"2 H2O + NH4(+) + 6 oxidized [2Fe-2S]-[ferredoxin] => 8 H(+) + nitrite + 6 reduced [2Fe-2S]-[ferredoxin]"}
{"X":21077,"RHEA_ID":18043,"DIRECTION":"RL","MASTER_ID":18041,"metacyc":"FERREDOXIN--NITRITE-REDUCTASE-RXN","compounds":"8 H(+) + nitrite + 6 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + NH4(+) + 6 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":21078,"RHEA_ID":18045,"DIRECTION":"UN","MASTER_ID":18045,"ec":"3.1.4.51","compounds":"6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H2O = alpha-D-glucose 1-phosphate + alpha-D-mannose derivative + H(+)"}
{"X":21079,"RHEA_ID":18046,"DIRECTION":"LR","MASTER_ID":18045,"metacyc":"3.1.4.51-RXN","compounds":"6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H2O => alpha-D-glucose 1-phosphate + alpha-D-mannose derivative + H(+)"}
{"X":21080,"RHEA_ID":18047,"compounds":"alpha-D-glucose 1-phosphate + alpha-D-mannose derivative + H(+) => 6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H2O"}
{"X":21081,"RHEA_ID":18049,"DIRECTION":"UN","MASTER_ID":18049,"ec":"2.6.1.11","compounds":"2-oxoglutarate + N(2)-acetyl-L-ornithine = L-glutamate + N-acetyl-L-glutamate 5-semialdehyde"}
{"X":21082,"RHEA_ID":18050,"compounds":"2-oxoglutarate + N(2)-acetyl-L-ornithine => L-glutamate + N-acetyl-L-glutamate 5-semialdehyde"}
{"X":21083,"RHEA_ID":18051,"compounds":"L-glutamate + N-acetyl-L-glutamate 5-semialdehyde => 2-oxoglutarate + N(2)-acetyl-L-ornithine"}
{"X":21084,"RHEA_ID":28703,"compounds":"Cu(2+)(in) = Cu(2+)(out)"}
{"X":21085,"RHEA_ID":18053,"DIRECTION":"UN","MASTER_ID":18053,"ec":"3.1.8.1","compounds":"H2O + paraoxon = 4-nitrophenol + diethylphosphate + 2 H(+)"}
{"X":21086,"RHEA_ID":18054,"DIRECTION":"LR","MASTER_ID":18053,"metacyc":"RXN-8746","compounds":"H2O + paraoxon => 4-nitrophenol + diethylphosphate + 2 H(+)"}
{"X":21087,"RHEA_ID":18055,"compounds":"4-nitrophenol + diethylphosphate + 2 H(+) => H2O + paraoxon"}
{"X":21088,"RHEA_ID":28707,"compounds":"Cd(2+)(in) = Cd(2+)(out)"}
{"X":21089,"RHEA_ID":18057,"DIRECTION":"UN","MASTER_ID":18057,"ec":"1.13.12.8","compounds":"O2 + Watasenia luciferin = CO2 + hnu + oxidized Watasenia luciferin"}
{"X":21090,"RHEA_ID":18058,"DIRECTION":"LR","MASTER_ID":18057,"metacyc":"WATASEMIA-LUCIFERIN-2-MONOOXYGENASE-RXN","compounds":"O2 + Watasenia luciferin => CO2 + hnu + oxidized Watasenia luciferin"}
{"X":21091,"RHEA_ID":18059,"compounds":"CO2 + hnu + oxidized Watasenia luciferin => O2 + Watasenia luciferin"}
{"X":21092,"RHEA_ID":28711,"compounds":"H(+)(in) + N-(4-aminobenzoyl)-L-glutamate(in) = H(+)(out) + N-(4-aminobenzoyl)-L-glutamate(out)"}
{"X":21093,"RHEA_ID":18061,"DIRECTION":"UN","MASTER_ID":18061,"ec":"2.3.1.101","compounds":"5,6,7,8-tetrahydromethanopterin + H(+) + N-formylmethanofuran = methanofuran + N(5)-formyl-5,6,7,8-tetrahydromethanopterin"}
{"X":21094,"RHEA_ID":18062,"compounds":"5,6,7,8-tetrahydromethanopterin + H(+) + N-formylmethanofuran => methanofuran + N(5)-formyl-5,6,7,8-tetrahydromethanopterin"}
{"X":21095,"RHEA_ID":18063,"compounds":"methanofuran + N(5)-formyl-5,6,7,8-tetrahydromethanopterin => 5,6,7,8-tetrahydromethanopterin + H(+) + N-formylmethanofuran"}
{"X":21096,"RHEA_ID":28715,"compounds":"(R)-malate(in) + 2 H(+)(in) = (R)-malate(out) + 2 H(+)(out)"}
{"X":21097,"RHEA_ID":18065,"DIRECTION":"UN","MASTER_ID":18065,"ec":"7.3.2.2","compounds":"ATP + H2O + phosphonate(out) = ADP + H(+) + phosphate + phosphonate(in)"}
{"X":21098,"RHEA_ID":18066,"DIRECTION":"LR","MASTER_ID":18065,"metacyc":"3.6.3.28-RXN","compounds":"ATP + H2O + phosphonate(out) => ADP + H(+) + phosphate + phosphonate(in)"}
{"X":21099,"RHEA_ID":18067,"compounds":"ADP + H(+) + phosphate + phosphonate(in) => ATP + H2O + phosphonate(out)"}
{"X":21100,"RHEA_ID":18068,"compounds":"ATP + H2O + phosphonate(out) <=> ADP + H(+) + phosphate + phosphonate(in)"}
{"X":21101,"RHEA_ID":18069,"DIRECTION":"UN","MASTER_ID":18069,"ec":"5.1.1.9","compounds":"L-arginine = D-arginine"}
{"X":21102,"RHEA_ID":18070,"compounds":"L-arginine => D-arginine"}
{"X":21103,"RHEA_ID":18071,"compounds":"D-arginine => L-arginine"}
{"X":21104,"RHEA_ID":28723,"compounds":"(S)-allantoin(in) + H(+)(in) = (S)-allantoin(out) + H(+)(out)"}
{"X":21105,"RHEA_ID":18073,"compounds":"(S)-dihydroorotate + A = AH2 + orotate"}
{"X":21106,"RHEA_ID":18074,"DIRECTION":"LR","MASTER_ID":18073,"ecocyc":"RXN0-6491","metacyc":"DIHYDROOROTATE-DEHYDROGENASE-RXN","compounds":"(S)-dihydroorotate + A => AH2 + orotate"}
{"X":21107,"RHEA_ID":18074,"DIRECTION":"LR","MASTER_ID":18073,"ecocyc":"RXN0-6491","metacyc":"RXN0-6491","compounds":"(S)-dihydroorotate + A => AH2 + orotate"}
{"X":21108,"RHEA_ID":18075,"compounds":"AH2 + orotate => (S)-dihydroorotate + A"}
{"X":21109,"RHEA_ID":28728,"DIRECTION":"LR","MASTER_ID":28727,"ecocyc":"TRANS-RXN0-280","compounds":"Cu(2+)(in) + H(+)(in) => Cu(2+)(out) + H(+)(out)"}
{"X":21110,"RHEA_ID":18077,"DIRECTION":"UN","MASTER_ID":18077,"ec":"2.4.2.37","compounds":"L-arginyl-[dinitrogen reductase] + NAD(+) = H(+) + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] + nicotinamide"}
{"X":21111,"RHEA_ID":18078,"compounds":"L-arginyl-[dinitrogen reductase] + NAD(+) => H(+) + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] + nicotinamide"}
{"X":21112,"RHEA_ID":18079,"compounds":"H(+) + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] + nicotinamide => L-arginyl-[dinitrogen reductase] + NAD(+)"}
{"X":21113,"RHEA_ID":28732,"DIRECTION":"LR","MASTER_ID":28731,"ecocyc":"TRANS-RXN0-270","compounds":"H(+)(out) + L-leucine(in) => H(+)(in) + L-leucine(out)"}
{"X":21114,"RHEA_ID":18081,"DIRECTION":"UN","MASTER_ID":18081,"ec":"4.2.3.7","compounds":"(2E,6E)-farnesyl diphosphate = diphosphate + pentalenene"}
{"X":21115,"RHEA_ID":18082,"DIRECTION":"LR","MASTER_ID":18081,"macie":"M0089","metacyc":"PENTALENENE-SYNTHASE-RXN","compounds":"(2E,6E)-farnesyl diphosphate => diphosphate + pentalenene"}
{"X":21116,"RHEA_ID":18083,"compounds":"diphosphate + pentalenene => (2E,6E)-farnesyl diphosphate"}
{"X":21117,"RHEA_ID":28736,"DIRECTION":"LR","MASTER_ID":28735,"ecocyc":"TRANS-RXN0-266","compounds":"H(+)(in) + spermidine(out) => H(+)(out) + spermidine(in)"}
{"X":21118,"RHEA_ID":18085,"DIRECTION":"UN","MASTER_ID":18085,"ec":"1.8.98.1","compounds":"coenzyme B + coenzyme M + methanophenazine = coenzyme M-coenzyme B heterodisulfide + dihydromethanophenazine"}
{"X":21119,"RHEA_ID":18086,"compounds":"coenzyme B + coenzyme M + methanophenazine => coenzyme M-coenzyme B heterodisulfide + dihydromethanophenazine"}
{"X":21120,"RHEA_ID":18087,"compounds":"coenzyme M-coenzyme B heterodisulfide + dihydromethanophenazine => coenzyme B + coenzyme M + methanophenazine"}
{"X":21121,"RHEA_ID":28740,"DIRECTION":"LR","MASTER_ID":28739,"ecocyc":"TRANS-RXN0-244","compounds":"Cd(2+)(in) + H(+)(out) => Cd(2+)(out) + H(+)(in)"}
{"X":21122,"RHEA_ID":18089,"DIRECTION":"UN","MASTER_ID":18089,"ec":"3.5.3.15","compounds":"H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4(+)"}
{"X":21123,"RHEA_ID":18090,"DIRECTION":"LR","MASTER_ID":18089,"metacyc":"PROTEIN-ARGININE-DEIMINASE-RXN","compounds":"H2O + L-arginyl-[protein] => L-citrullyl-[protein] + NH4(+)"}
{"X":21124,"RHEA_ID":18091,"compounds":"L-citrullyl-[protein] + NH4(+) => H2O + L-arginyl-[protein]"}
{"X":21125,"RHEA_ID":18093,"DIRECTION":"UN","MASTER_ID":18093,"ec":"1.3.1.2","compounds":"5,6-dihydrouracil + NADP(+) = H(+) + NADPH + uracil"}
{"X":21126,"RHEA_ID":18094,"compounds":"5,6-dihydrouracil + NADP(+) => H(+) + NADPH + uracil"}
{"X":21127,"RHEA_ID":18095,"DIRECTION":"RL","MASTER_ID":18093,"reactome":"R-HSA-73585.2","compounds":"H(+) + NADPH + uracil => 5,6-dihydrouracil + NADP(+)"}
{"X":21128,"RHEA_ID":28748,"compounds":"NH4(+)(in) => NH4(+)(out)"}
{"X":21129,"RHEA_ID":18097,"DIRECTION":"UN","MASTER_ID":18097,"ec":"5.5.1.3","metacyc":"TETRAHYDROXYPTERIDINE-CYCLOISOMERASE-RXN","compounds":"pteridine-2,4,6,7-tetrol = H(+) + xanthine-8-carboxylate"}
{"X":21130,"RHEA_ID":18098,"compounds":"pteridine-2,4,6,7-tetrol => H(+) + xanthine-8-carboxylate"}
{"X":21131,"RHEA_ID":18099,"compounds":"H(+) + xanthine-8-carboxylate => pteridine-2,4,6,7-tetrol"}
{"X":21132,"RHEA_ID":28752,"compounds":"sn-glycerol 3-phosphate + ubiquinone-8 => dihydroxyacetone phosphate + ubiquinol-8"}
{"X":21133,"RHEA_ID":18101,"DIRECTION":"UN","MASTER_ID":18101,"ec":"1.3.1.66","metacyc":"1.3.1.66-RXN","compounds":"cis-1,2-dihydro-3-ethylcatechol + NAD(+) = 3-ethylcatechol + H(+) + NADH"}
{"X":21134,"RHEA_ID":18102,"compounds":"cis-1,2-dihydro-3-ethylcatechol + NAD(+) => 3-ethylcatechol + H(+) + NADH"}
{"X":21135,"RHEA_ID":18103,"compounds":"3-ethylcatechol + H(+) + NADH => cis-1,2-dihydro-3-ethylcatechol + NAD(+)"}
{"X":21136,"RHEA_ID":28756,"DIRECTION":"LR","MASTER_ID":28755,"ecocyc":"RXN0-5260","metacyc":"RXN0-5260","compounds":"a ubiquinone + sn-glycerol 3-phosphate => a ubiquinol + dihydroxyacetone phosphate"}
{"X":21137,"RHEA_ID":18105,"DIRECTION":"UN","MASTER_ID":18105,"ec":"7.2.2.10","compounds":"ATP + Ca(2+)(in) + H2O = ADP + Ca(2+)(out) + H(+) + phosphate"}
{"X":21138,"RHEA_ID":18106,"DIRECTION":"LR","MASTER_ID":18105,"metacyc":"3.6.3.8-RXN","compounds":"ATP + Ca(2+)(in) + H2O => ADP + Ca(2+)(out) + H(+) + phosphate"}
{"X":21139,"RHEA_ID":18107,"compounds":"ADP + Ca(2+)(out) + H(+) + phosphate => ATP + Ca(2+)(in) + H2O"}
{"X":21140,"RHEA_ID":18108,"compounds":"ATP + Ca(2+)(in) + H2O <=> ADP + Ca(2+)(out) + H(+) + phosphate"}
{"X":21141,"RHEA_ID":18109,"DIRECTION":"UN","MASTER_ID":18109,"ec":"2.5.1.42","compounds":"all-trans-geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate = 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate + diphosphate"}
{"X":21142,"RHEA_ID":18110,"DIRECTION":"LR","MASTER_ID":18109,"metacyc":"2.5.1.42-RXN","compounds":"all-trans-geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate => 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate + diphosphate"}
{"X":21143,"RHEA_ID":18111,"compounds":"2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate + diphosphate => all-trans-geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate"}
{"X":21144,"RHEA_ID":28764,"DIRECTION":"LR","MASTER_ID":28763,"ecocyc":"TDPFUCACTRANS-RXN","metacyc":"TDPFUCACTRANS-RXN","compounds":"acetyl-CoA + dTDP-4-amino-4,6-dideoxy-D-galactose => CoA + dTDP-4-acetamido-4,6-dideoxy-D-galactose + H(+)"}
{"X":21145,"RHEA_ID":18113,"DIRECTION":"UN","MASTER_ID":18113,"ec":"2.7.4.6","compounds":"a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP"}
{"X":21146,"RHEA_ID":18114,"DIRECTION":"LR","MASTER_ID":18113,"ecocyc":"NUCLEOSIDE-DIP-KIN-RXN","metacyc":"NUCLEOSIDE-DIP-KIN-RXN","compounds":"a ribonucleoside 5'-diphosphate + ATP => a ribonucleoside 5'-triphosphate + ADP"}
{"X":21147,"RHEA_ID":18115,"compounds":"a ribonucleoside 5'-triphosphate + ADP => a ribonucleoside 5'-diphosphate + ATP"}
{"X":21148,"RHEA_ID":28768,"DIRECTION":"LR","MASTER_ID":28767,"metacyc":"2-NITROPROPANE-DIOXYGENASE-RXN","compounds":"ethylnitronate + O2 => acetaldehyde + chemical entity + H(+) + nitrite"}
{"X":21149,"RHEA_ID":18117,"DIRECTION":"UN","MASTER_ID":18117,"ec":"1.14.18.1","compounds":"L-tyrosine + O2 = H2O + L-dopaquinone"}
{"X":21150,"RHEA_ID":18118,"DIRECTION":"LR","MASTER_ID":18117,"metacyc":"MONOPHENOL-MONOOXYGENASE-RXN","compounds":"L-tyrosine + O2 => H2O + L-dopaquinone"}
{"X":21151,"RHEA_ID":18119,"compounds":"H2O + L-dopaquinone => L-tyrosine + O2"}
{"X":21152,"RHEA_ID":18120,"compounds":"L-tyrosine + O2 <=> H2O + L-dopaquinone"}
{"X":21153,"RHEA_ID":18121,"DIRECTION":"UN","MASTER_ID":18121,"ec":"4.4.1.13","compounds":"an S-substituted L-cysteine + H2O = a thiol + NH4(+) + pyruvate"}
{"X":21154,"RHEA_ID":18122,"DIRECTION":"LR","MASTER_ID":18121,"metacyc":"RXN-6763","compounds":"an S-substituted L-cysteine + H2O => a thiol + NH4(+) + pyruvate"}
{"X":21155,"RHEA_ID":18123,"compounds":"a thiol + NH4(+) + pyruvate => an S-substituted L-cysteine + H2O"}
{"X":21156,"RHEA_ID":18125,"compounds":"A + a D-alpha-amino acid + H2O = a 2-oxocarboxylate + AH2 + NH4(+)"}
{"X":21157,"RHEA_ID":18126,"compounds":"A + a D-alpha-amino acid + H2O => a 2-oxocarboxylate + AH2 + NH4(+)"}
{"X":21158,"RHEA_ID":18127,"compounds":"a 2-oxocarboxylate + AH2 + NH4(+) => A + a D-alpha-amino acid + H2O"}
{"X":21159,"RHEA_ID":18129,"DIRECTION":"UN","MASTER_ID":18129,"ec":"1.2.1.49","metacyc":"2-OXOALDEHYDE-DEHYDROGENASE-NADP%2b-RXN","compounds":"2-oxoaldehyde + H2O + NADP(+) = a 2-oxocarboxylate + 2 H(+) + NADPH"}
{"X":21160,"RHEA_ID":18130,"compounds":"2-oxoaldehyde + H2O + NADP(+) => a 2-oxocarboxylate + 2 H(+) + NADPH"}
{"X":21161,"RHEA_ID":18131,"compounds":"a 2-oxocarboxylate + 2 H(+) + NADPH => 2-oxoaldehyde + H2O + NADP(+)"}
{"X":21162,"RHEA_ID":18133,"DIRECTION":"UN","MASTER_ID":18133,"ec":"2.7.7.4","compounds":"ATP + H(+) + sulfate = adenosine 5'-phosphosulfate + diphosphate"}
{"X":21163,"RHEA_ID":18134,"DIRECTION":"LR","MASTER_ID":18133,"macie":"M0287","reactome":"R-HSA-174392.2","compounds":"ATP + H(+) + sulfate => adenosine 5'-phosphosulfate + diphosphate"}
{"X":21164,"RHEA_ID":18135,"compounds":"adenosine 5'-phosphosulfate + diphosphate => ATP + H(+) + sulfate"}
{"X":21165,"RHEA_ID":28789,"compounds":"4-(phosphooxy)-L-threonine + ADP + H(+) => 4-hydroxy-L-threonine + ATP"}
{"X":21166,"RHEA_ID":18137,"DIRECTION":"UN","MASTER_ID":18137,"ec":"1.1.1.278","compounds":"3beta-hydroxy-5alpha-pregnane-20-one + NADP(+) = 5alpha-pregnane-3,20-dione + H(+) + NADPH"}
{"X":21167,"RHEA_ID":18138,"compounds":"3beta-hydroxy-5alpha-pregnane-20-one + NADP(+) => 5alpha-pregnane-3,20-dione + H(+) + NADPH"}
{"X":21168,"RHEA_ID":18139,"DIRECTION":"RL","MASTER_ID":18137,"metacyc":"1.1.1.278-RXN","compounds":"5alpha-pregnane-3,20-dione + H(+) + NADPH => 3beta-hydroxy-5alpha-pregnane-20-one + NADP(+)"}
{"X":21169,"RHEA_ID":28793,"compounds":"H(+) + NADH + thymine => 5,6-dihydrothymine + NAD(+)"}
{"X":21170,"RHEA_ID":18141,"DIRECTION":"UN","MASTER_ID":18141,"ec":"1.1.1.174","metacyc":"CYCLOHEXANE-12-DIOL-DEHYDROGENASE-RXN","compounds":"NAD(+) + trans-cyclohexane-1,2-diol = 2-hydroxycyclohexan-1-one + H(+) + NADH"}
{"X":21171,"RHEA_ID":18142,"compounds":"NAD(+) + trans-cyclohexane-1,2-diol => 2-hydroxycyclohexan-1-one + H(+) + NADH"}
{"X":21172,"RHEA_ID":18143,"compounds":"2-hydroxycyclohexan-1-one + H(+) + NADH => NAD(+) + trans-cyclohexane-1,2-diol"}
{"X":21173,"RHEA_ID":28796,"compounds":"2 a Fe(II)-siderophore + H(+) + NADP(+) => 2 a Fe(III)-siderophore + NADPH"}
{"X":21174,"RHEA_ID":18145,"DIRECTION":"UN","MASTER_ID":18145,"ec":"2.7.1.3","compounds":"ATP + beta-D-fructose = ADP + beta-D-fructose 1-phosphate + H(+)"}
{"X":21175,"RHEA_ID":18146,"DIRECTION":"LR","MASTER_ID":18145,"metacyc":"KETOHEXOKINASE-RXN","compounds":"ATP + beta-D-fructose => ADP + beta-D-fructose 1-phosphate + H(+)"}
{"X":21176,"RHEA_ID":18147,"compounds":"ADP + beta-D-fructose 1-phosphate + H(+) => ATP + beta-D-fructose"}
{"X":21177,"RHEA_ID":28800,"compounds":"H2O + L-prolinylglycine => glycine + L-proline"}
{"X":21178,"RHEA_ID":18149,"compounds":"H2O + N-acetyl-D-galactosamine 6-phosphate = acetate + D-galactosamine 6-phosphate"}
{"X":21179,"RHEA_ID":18150,"DIRECTION":"LR","MASTER_ID":18149,"metacyc":"3.5.1.80-RXN","compounds":"H2O + N-acetyl-D-galactosamine 6-phosphate => acetate + D-galactosamine 6-phosphate"}
{"X":21180,"RHEA_ID":18151,"compounds":"acetate + D-galactosamine 6-phosphate => H2O + N-acetyl-D-galactosamine 6-phosphate"}
{"X":21181,"RHEA_ID":28804,"DIRECTION":"LR","MASTER_ID":28803,"ecocyc":"RXN0-5214","metacyc":"RXN0-5214","compounds":"H2O + L-ascorbate 6-phosphate => 3-dehydro-L-gulonate 6-phosphate"}
{"X":21182,"RHEA_ID":18153,"DIRECTION":"UN","MASTER_ID":18153,"ec":"2.7.7.45","metacyc":"2.7.7.45-RXN","compounds":"2 GTP + H(+) = diphosphate + P(1),P(4)-bis(5'-guanosyl) tetraphosphate"}
{"X":21183,"RHEA_ID":18154,"compounds":"2 GTP + H(+) => diphosphate + P(1),P(4)-bis(5'-guanosyl) tetraphosphate"}
{"X":21184,"RHEA_ID":18155,"compounds":"diphosphate + P(1),P(4)-bis(5'-guanosyl) tetraphosphate => 2 GTP + H(+)"}
{"X":21185,"RHEA_ID":28808,"DIRECTION":"LR","MASTER_ID":28807,"reactome":"R-HSA-8943279.2","compounds":"glutathione + H2O => L-cysteinylglycine + L-glutamate"}
{"X":21186,"RHEA_ID":18157,"DIRECTION":"UN","MASTER_ID":18157,"ec":"2.7.1.40","compounds":"ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate"}
{"X":21187,"RHEA_ID":18158,"compounds":"ATP + pyruvate => ADP + H(+) + phosphoenolpyruvate"}
{"X":21188,"RHEA_ID":18159,"DIRECTION":"RL","MASTER_ID":18157,"ecocyc":"PEPDEPHOS-RXN","metacyc":"PEPDEPHOS-RXN","reactome":"R-HSA-71670.4","compounds":"ADP + H(+) + phosphoenolpyruvate => ATP + pyruvate"}
{"X":21189,"RHEA_ID":28812,"compounds":"2,3-dioxo-L-gulonate(in) + Na(+)(in) => 2,3-dioxo-L-gulonate(out) + Na(+)(out)"}
{"X":21190,"RHEA_ID":18161,"DIRECTION":"UN","MASTER_ID":18161,"ec":"2.3.1.155","compounds":"acetyl-CoA + tetradecanoyl-CoA = 3-oxohexadecanoyl-CoA + CoA"}
{"X":21191,"RHEA_ID":18162,"compounds":"acetyl-CoA + tetradecanoyl-CoA => 3-oxohexadecanoyl-CoA + CoA"}
{"X":21192,"RHEA_ID":18163,"DIRECTION":"RL","MASTER_ID":18161,"metacyc":"2.3.1.155-RXN","reactome":"R-HSA-77304.2","compounds":"3-oxohexadecanoyl-CoA + CoA => acetyl-CoA + tetradecanoyl-CoA"}
{"X":21193,"RHEA_ID":28816,"DIRECTION":"LR","MASTER_ID":28815,"ecocyc":"TRANS-RXN0-233","compounds":"4-hydroxybenzoate(in) + H(+)(out) => 4-hydroxybenzoate(out) + H(+)(in)"}
{"X":21194,"RHEA_ID":18165,"DIRECTION":"UN","MASTER_ID":18165,"ec":"1.14.12.18","compounds":"biphenyl + H(+) + NADH + O2 = (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+)"}
{"X":21195,"RHEA_ID":18166,"DIRECTION":"LR","MASTER_ID":18165,"metacyc":"1.14.12.18-RXN","compounds":"biphenyl + H(+) + NADH + O2 => (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+)"}
{"X":21196,"RHEA_ID":18167,"compounds":"(2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+) => biphenyl + H(+) + NADH + O2"}
{"X":21197,"RHEA_ID":28820,"compounds":"5-dehydro-D-gluconate(in) + H(+)(in) => 5-dehydro-D-gluconate(out) + H(+)(out)"}
{"X":21198,"RHEA_ID":18169,"DIRECTION":"UN","MASTER_ID":18169,"ec":"4.1.3.16","compounds":"4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate"}
{"X":21199,"RHEA_ID":18170,"DIRECTION":"LR","MASTER_ID":18169,"reactome":"R-HSA-6784423.2","compounds":"4-hydroxy-2-oxoglutarate => glyoxylate + pyruvate"}
{"X":21200,"RHEA_ID":18171,"compounds":"glyoxylate + pyruvate => 4-hydroxy-2-oxoglutarate"}
{"X":21201,"RHEA_ID":18173,"DIRECTION":"UN","MASTER_ID":18173,"ec":"4.2.1.87","compounds":"(2R)-1-(4-hydroxyphenyl)-2-aminoethanol = (4-hydroxyphenyl)acetaldehyde + NH4(+)"}
{"X":21202,"RHEA_ID":18174,"DIRECTION":"LR","MASTER_ID":18173,"metacyc":"OCTOPAMINE-DEHYDRATASE-RXN","compounds":"(2R)-1-(4-hydroxyphenyl)-2-aminoethanol => (4-hydroxyphenyl)acetaldehyde + NH4(+)"}
{"X":21203,"RHEA_ID":18175,"compounds":"(4-hydroxyphenyl)acetaldehyde + NH4(+) => (2R)-1-(4-hydroxyphenyl)-2-aminoethanol"}
{"X":21204,"RHEA_ID":28828,"DIRECTION":"LR","MASTER_ID":28827,"ecocyc":"TRANS-RXN0-211","compounds":"L-ornithine(out) + putrescine(in) => L-ornithine(in) + putrescine(out)"}
{"X":21205,"RHEA_ID":18177,"DIRECTION":"UN","MASTER_ID":18177,"ec":"1.3.1.44","compounds":"a 2,3-saturated acyl-CoA + NAD(+) = a (2E)-enoyl-CoA + H(+) + NADH"}
{"X":21206,"RHEA_ID":18178,"compounds":"a 2,3-saturated acyl-CoA + NAD(+) => a (2E)-enoyl-CoA + H(+) + NADH"}
{"X":21207,"RHEA_ID":18179,"DIRECTION":"RL","MASTER_ID":18177,"metacyc":"TRANS-2-ENOYL-COA-REDUCTASE-NAD%2b-RXN","compounds":"a (2E)-enoyl-CoA + H(+) + NADH => a 2,3-saturated acyl-CoA + NAD(+)"}
{"X":21208,"RHEA_ID":18181,"DIRECTION":"UN","MASTER_ID":18181,"ec":"2.3.3.9","compounds":"acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA + H(+)"}
{"X":21209,"RHEA_ID":18182,"DIRECTION":"LR","MASTER_ID":18181,"ecocyc":"MALSYN-RXN","macie":"M0053","metacyc":"MALSYN-RXN","compounds":"acetyl-CoA + glyoxylate + H2O => (S)-malate + CoA + H(+)"}
{"X":21210,"RHEA_ID":18183,"compounds":"(S)-malate + CoA + H(+) => acetyl-CoA + glyoxylate + H2O"}
{"X":21211,"RHEA_ID":28836,"DIRECTION":"LR","MASTER_ID":28835,"ecocyc":"TRANS-RXN0-201","compounds":"citrate(out) + succinate(in) => citrate(in) + succinate(out)"}
{"X":21212,"RHEA_ID":18185,"compounds":"adenosine + O2 = 5'-dehydroadenosine + H2O2"}
{"X":21213,"RHEA_ID":18186,"DIRECTION":"LR","MASTER_ID":18185,"metacyc":"RXN-11786","compounds":"adenosine + O2 => 5'-dehydroadenosine + H2O2"}
{"X":21214,"RHEA_ID":18187,"compounds":"5'-dehydroadenosine + H2O2 => adenosine + O2"}
{"X":21215,"RHEA_ID":28840,"DIRECTION":"LR","MASTER_ID":28839,"ecocyc":"TRANS-RXN0-200","compounds":"H(+)(out) + Zn(2+)(in) => H(+)(in) + Zn(2+)(out)"}
{"X":21216,"RHEA_ID":18189,"DIRECTION":"UN","MASTER_ID":18189,"ec":"2.4.1.21","compounds":"[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-alpha-D-glucosyl](n+1) + ADP + H(+)"}
{"X":21217,"RHEA_ID":18190,"compounds":"[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose => [(1->4)-alpha-D-glucosyl](n+1) + ADP + H(+)"}
{"X":21218,"RHEA_ID":18191,"compounds":"[(1->4)-alpha-D-glucosyl](n+1) + ADP + H(+) => [(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose"}
{"X":21219,"RHEA_ID":28844,"compounds":"choline(in) + H(+)(in) => choline(out) + H(+)(out)"}
{"X":21220,"RHEA_ID":18193,"compounds":"H2O + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] = (S)-4,5-dihydroxy-2-oxopentanal + L-lysyl-[protein] + phosphate"}
{"X":21221,"RHEA_ID":18194,"compounds":"H2O + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] => (S)-4,5-dihydroxy-2-oxopentanal + L-lysyl-[protein] + phosphate"}
{"X":21222,"RHEA_ID":18195,"compounds":"(S)-4,5-dihydroxy-2-oxopentanal + L-lysyl-[protein] + phosphate => H2O + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein]"}
{"X":21223,"RHEA_ID":18196,"compounds":"H2O + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] <=> (S)-4,5-dihydroxy-2-oxopentanal + L-lysyl-[protein] + phosphate"}
{"X":21224,"RHEA_ID":18197,"DIRECTION":"UN","MASTER_ID":18197,"ec":"4.2.1.103","compounds":"H(+) + N-cyclohexylformamide = cyclohexyl isocyanide + H2O"}
{"X":21225,"RHEA_ID":18198,"compounds":"H(+) + N-cyclohexylformamide => cyclohexyl isocyanide + H2O"}
{"X":21226,"RHEA_ID":18199,"compounds":"cyclohexyl isocyanide + H2O => H(+) + N-cyclohexylformamide"}
{"X":21227,"RHEA_ID":28852,"compounds":"melibiose(in) + Na(+)(in) => melibiose(out) + Na(+)(out)"}
{"X":21228,"RHEA_ID":18201,"DIRECTION":"UN","MASTER_ID":18201,"ec":"1.14.16.2","compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa"}
{"X":21229,"RHEA_ID":18202,"DIRECTION":"LR","MASTER_ID":18201,"metacyc":"TYROSINE-3-MONOOXYGENASE-RXN","compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2 => (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa"}
{"X":21230,"RHEA_ID":18203,"compounds":"(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2"}
{"X":21231,"RHEA_ID":28856,"compounds":"H(+)(in) + melibiose(in) => H(+)(out) + melibiose(out)"}
{"X":21232,"RHEA_ID":18205,"DIRECTION":"UN","MASTER_ID":18205,"ec":"1.14.99.14","compounds":"AH2 + O2 + progesterone = 11alpha-hydroxyprogesterone + A + H2O"}
{"X":21233,"RHEA_ID":18206,"DIRECTION":"LR","MASTER_ID":18205,"metacyc":"PROGESTERONE-11-ALPHA-MONOOXYGENASE-RXN","compounds":"AH2 + O2 + progesterone => 11alpha-hydroxyprogesterone + A + H2O"}
{"X":21234,"RHEA_ID":18207,"compounds":"11alpha-hydroxyprogesterone + A + H2O => AH2 + O2 + progesterone"}
{"X":21235,"RHEA_ID":28860,"compounds":"Ag(+)(in) + H(+)(in) => Ag(+)(out) + H(+)(out)"}
{"X":21236,"RHEA_ID":18209,"DIRECTION":"UN","MASTER_ID":18209,"ec":"5.5.1.8","compounds":"(2E)-geranyl diphosphate = (2S,4R)-bornyl diphosphate"}
{"X":21237,"RHEA_ID":18210,"DIRECTION":"LR","MASTER_ID":18209,"metacyc":"GERANYL-DIPHOSPHATE-CYCLASE-RXN","compounds":"(2E)-geranyl diphosphate => (2S,4R)-bornyl diphosphate"}
{"X":21238,"RHEA_ID":18211,"compounds":"(2S,4R)-bornyl diphosphate => (2E)-geranyl diphosphate"}
{"X":21239,"RHEA_ID":28864,"DIRECTION":"LR","MASTER_ID":28863,"ecocyc":"TRANS-RXN-82","compounds":"H(+)(out) + lactose(in) => H(+)(in) + lactose(out)"}
{"X":21240,"RHEA_ID":18213,"DIRECTION":"UN","MASTER_ID":18213,"ec":"2.7.7.33","compounds":"alpha-D-glucose 1-phosphate + CTP + H(+) = CDP-D-glucose + diphosphate"}
{"X":21241,"RHEA_ID":18214,"compounds":"alpha-D-glucose 1-phosphate + CTP + H(+) => CDP-D-glucose + diphosphate"}
{"X":21242,"RHEA_ID":18215,"compounds":"CDP-D-glucose + diphosphate => alpha-D-glucose 1-phosphate + CTP + H(+)"}
{"X":21243,"RHEA_ID":28868,"compounds":"H(+)(in) + lactose(in) => H(+)(out) + lactose(out)"}
{"X":21244,"RHEA_ID":18217,"DIRECTION":"UN","MASTER_ID":18217,"ec":"2.6.1.29","compounds":"2-oxoglutarate + an alkane-alpha,omega-diamine = an omega-aminoaldehyde + L-glutamate"}
{"X":21245,"RHEA_ID":18218,"compounds":"2-oxoglutarate + an alkane-alpha,omega-diamine => an omega-aminoaldehyde + L-glutamate"}
{"X":21246,"RHEA_ID":18219,"compounds":"an omega-aminoaldehyde + L-glutamate => 2-oxoglutarate + an alkane-alpha,omega-diamine"}
{"X":21247,"RHEA_ID":28872,"compounds":"D-fructuronate(in) + H(+)(in) => D-fructuronate(out) + H(+)(out)"}
{"X":21248,"RHEA_ID":18221,"DIRECTION":"UN","MASTER_ID":18221,"ec":"3.1.3.59","compounds":"1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + H2O = a 1-O-alkyl-2-acetyl-sn-glycerol + phosphate"}
{"X":21249,"RHEA_ID":18222,"DIRECTION":"LR","MASTER_ID":18221,"metacyc":"ALKYLACETYLGLYCEROPHOSPHATASE-RXN","compounds":"1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + H2O => a 1-O-alkyl-2-acetyl-sn-glycerol + phosphate"}
{"X":21250,"RHEA_ID":18223,"compounds":"a 1-O-alkyl-2-acetyl-sn-glycerol + phosphate => 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + H2O"}
{"X":21251,"RHEA_ID":18225,"DIRECTION":"UN","MASTER_ID":18225,"ec":"3.5.1.46","compounds":"[N-(6-aminohexanoyl)](n) + H2O = 6-aminohexanoate + [N-(6-aminohexanoyl)](n-1)"}
{"X":21252,"RHEA_ID":18226,"compounds":"[N-(6-aminohexanoyl)](n) + H2O => 6-aminohexanoate + [N-(6-aminohexanoyl)](n-1)"}
{"X":21253,"RHEA_ID":18227,"compounds":"6-aminohexanoate + [N-(6-aminohexanoyl)](n-1) => [N-(6-aminohexanoyl)](n) + H2O"}
{"X":21254,"RHEA_ID":18229,"DIRECTION":"UN","MASTER_ID":18229,"ec":"1.1.1.26","compounds":"glycolate + NAD(+) = glyoxylate + H(+) + NADH"}
{"X":21255,"RHEA_ID":18230,"compounds":"glycolate + NAD(+) => glyoxylate + H(+) + NADH"}
{"X":21256,"RHEA_ID":18231,"compounds":"glyoxylate + H(+) + NADH => glycolate + NAD(+)"}
{"X":21257,"RHEA_ID":18237,"DIRECTION":"UN","MASTER_ID":18237,"ec":"1.13.11.4","compounds":"2,5-dihydroxybenzoate + O2 = 3-maleylpyruvate + H(+)"}
{"X":21258,"RHEA_ID":18238,"DIRECTION":"LR","MASTER_ID":18237,"metacyc":"GENTISATE-12-DIOXYGENASE-RXN","compounds":"2,5-dihydroxybenzoate + O2 => 3-maleylpyruvate + H(+)"}
{"X":21259,"RHEA_ID":18239,"compounds":"3-maleylpyruvate + H(+) => 2,5-dihydroxybenzoate + O2"}
{"X":21260,"RHEA_ID":28888,"compounds":"H(+)(in) + L-serine(in) => H(+)(out) + L-serine(out)"}
{"X":21261,"RHEA_ID":18241,"DIRECTION":"UN","MASTER_ID":18241,"ec":"5.4.3.4","compounds":"D-lysine = (2R,5S)-2,5-diaminohexanoate"}
{"X":21262,"RHEA_ID":18241,"DIRECTION":"UN","MASTER_ID":18241,"ec":"5.4.3.3","compounds":"D-lysine = (2R,5S)-2,5-diaminohexanoate"}
{"X":21263,"RHEA_ID":18242,"compounds":"D-lysine => (2R,5S)-2,5-diaminohexanoate"}
{"X":21264,"RHEA_ID":18243,"compounds":"(2R,5S)-2,5-diaminohexanoate => D-lysine"}
{"X":21265,"RHEA_ID":28893,"DIRECTION":"RL","MASTER_ID":28891,"ecocyc":"TRANS-RXN-69","compounds":"H(+)(out) + putrescine(out) => H(+)(in) + putrescine(in)"}
{"X":21266,"RHEA_ID":18245,"DIRECTION":"UN","MASTER_ID":18245,"ec":"2.7.1.24","compounds":"3'-dephospho-CoA + ATP = ADP + CoA + H(+)"}
{"X":21267,"RHEA_ID":18246,"DIRECTION":"LR","MASTER_ID":18245,"ecocyc":"DEPHOSPHOCOAKIN-RXN","metacyc":"DEPHOSPHOCOAKIN-RXN","reactome":"R-HSA-196773.2","compounds":"3'-dephospho-CoA + ATP => ADP + CoA + H(+)"}
{"X":21268,"RHEA_ID":18247,"compounds":"ADP + CoA + H(+) => 3'-dephospho-CoA + ATP"}
{"X":21269,"RHEA_ID":28897,"compounds":"cadaverine(out) + L-lysine(in) => cadaverine(in) + L-lysine(out)"}
{"X":21270,"RHEA_ID":18253,"DIRECTION":"UN","MASTER_ID":18253,"ec":"1.1.1.40","compounds":"(S)-malate + NADP(+) = CO2 + NADPH + pyruvate"}
{"X":21271,"RHEA_ID":18254,"DIRECTION":"LR","MASTER_ID":18253,"ecocyc":"MALIC-NADP-RXN","macie":"M0021","metacyc":"MALIC-NADP-RXN","reactome":"R-HSA-9012349.1","compounds":"(S)-malate + NADP(+) => CO2 + NADPH + pyruvate"}
{"X":21272,"RHEA_ID":18254,"DIRECTION":"LR","MASTER_ID":18253,"ecocyc":"MALIC-NADP-RXN","macie":"M0021","metacyc":"MALIC-NADP-RXN","reactome":"R-HSA-9012036.1","compounds":"(S)-malate + NADP(+) => CO2 + NADPH + pyruvate"}
{"X":21273,"RHEA_ID":18255,"compounds":"CO2 + NADPH + pyruvate => (S)-malate + NADP(+)"}
{"X":21274,"RHEA_ID":28901,"DIRECTION":"RL","MASTER_ID":28899,"ecocyc":"TRANS-RXN-62B","compounds":"glycine(out) + H(+)(out) => glycine(in) + H(+)(in)"}
{"X":21275,"RHEA_ID":18257,"DIRECTION":"UN","MASTER_ID":18257,"ec":"1.3.3.3","compounds":"coproporphyrinogen III + 2 H(+) + O2 = 2 CO2 + 2 H2O + protoporphyrinogen IX"}
{"X":21276,"RHEA_ID":18258,"DIRECTION":"LR","MASTER_ID":18257,"ecocyc":"RXN0-1461","metacyc":"RXN0-1461","compounds":"coproporphyrinogen III + 2 H(+) + O2 => 2 CO2 + 2 H2O + protoporphyrinogen IX"}
{"X":21277,"RHEA_ID":18259,"compounds":"2 CO2 + 2 H2O + protoporphyrinogen IX => coproporphyrinogen III + 2 H(+) + O2"}
{"X":21278,"RHEA_ID":28905,"DIRECTION":"RL","MASTER_ID":28903,"ecocyc":"TRANS-RXN-62A","compounds":"D-alanine(out) + H(+)(out) => D-alanine(in) + H(+)(in)"}
{"X":21279,"RHEA_ID":18261,"DIRECTION":"UN","MASTER_ID":18261,"ec":"2.1.1.152","compounds":"H2O + precorrin-5 + S-adenosyl-L-methionine = acetate + 2 H(+) + precorrin-6A + S-adenosyl-L-homocysteine"}
{"X":21280,"RHEA_ID":18262,"DIRECTION":"LR","MASTER_ID":18261,"metacyc":"R322-RXN","compounds":"H2O + precorrin-5 + S-adenosyl-L-methionine => acetate + 2 H(+) + precorrin-6A + S-adenosyl-L-homocysteine"}
{"X":21281,"RHEA_ID":18263,"compounds":"acetate + 2 H(+) + precorrin-6A + S-adenosyl-L-homocysteine => H2O + precorrin-5 + S-adenosyl-L-methionine"}
{"X":21282,"RHEA_ID":28909,"DIRECTION":"RL","MASTER_ID":28907,"ecocyc":"TRANS-RXN-61","compounds":"3-(3-hydroxyphenyl)propanoate(out) + H(+)(out) => 3-(3-hydroxyphenyl)propanoate(in) + H(+)(in)"}
{"X":21283,"RHEA_ID":18265,"DIRECTION":"UN","MASTER_ID":18265,"ec":"1.1.1.368","compounds":"6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD(+) = 6-oxocyclohex-1-ene-1-carbonyl-CoA + H(+) + NADH"}
{"X":21284,"RHEA_ID":18266,"compounds":"6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD(+) => 6-oxocyclohex-1-ene-1-carbonyl-CoA + H(+) + NADH"}
{"X":21285,"RHEA_ID":18267,"compounds":"6-oxocyclohex-1-ene-1-carbonyl-CoA + H(+) + NADH => 6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD(+)"}
{"X":21286,"RHEA_ID":28913,"DIRECTION":"RL","MASTER_ID":28911,"ecocyc":"TRANS-RXN-58","metacyc":"TRANS-RXN-58","compounds":"H(+)(in) + L-lysine(in) => H(+)(out) + L-lysine(out)"}
{"X":21287,"RHEA_ID":18269,"DIRECTION":"UN","MASTER_ID":18269,"ec":"1.1.1.280","metacyc":"1.2.1.56-RXN","compounds":"ethyl (S)-3-hydroxyhexanoate + NADP(+) = ethyl 3-oxohexanoate + H(+) + NADPH"}
{"X":21288,"RHEA_ID":18270,"compounds":"ethyl (S)-3-hydroxyhexanoate + NADP(+) => ethyl 3-oxohexanoate + H(+) + NADPH"}
{"X":21289,"RHEA_ID":18271,"compounds":"ethyl 3-oxohexanoate + H(+) + NADPH => ethyl (S)-3-hydroxyhexanoate + NADP(+)"}
{"X":21290,"RHEA_ID":28917,"DIRECTION":"RL","MASTER_ID":28915,"ecocyc":"TRANS-RXN-57","compounds":"4-aminobutanoate(out) + H(+)(out) => 4-aminobutanoate(in) + H(+)(in)"}
{"X":21291,"RHEA_ID":18273,"DIRECTION":"UN","MASTER_ID":18273,"ec":"1.4.3.10","compounds":"H2O + O2 + putrescine = 4-aminobutanal + H2O2 + NH4(+)"}
{"X":21292,"RHEA_ID":18274,"DIRECTION":"LR","MASTER_ID":18273,"metacyc":"PUTRESCINE-OXIDASE-RXN","compounds":"H2O + O2 + putrescine => 4-aminobutanal + H2O2 + NH4(+)"}
{"X":21293,"RHEA_ID":18275,"compounds":"4-aminobutanal + H2O2 + NH4(+) => H2O + O2 + putrescine"}
{"X":21294,"RHEA_ID":18277,"DIRECTION":"UN","MASTER_ID":18277,"ec":"2.1.1.9","compounds":"a thiol + S-adenosyl-L-methionine = a methyl thioether + H(+) + S-adenosyl-L-homocysteine"}
{"X":21295,"RHEA_ID":18278,"DIRECTION":"LR","MASTER_ID":18277,"metacyc":"THIOL-S-METHYLTRANSFERASE-RXN","compounds":"a thiol + S-adenosyl-L-methionine => a methyl thioether + H(+) + S-adenosyl-L-homocysteine"}
{"X":21296,"RHEA_ID":18279,"compounds":"a methyl thioether + H(+) + S-adenosyl-L-homocysteine => a thiol + S-adenosyl-L-methionine"}
{"X":21297,"RHEA_ID":28925,"DIRECTION":"RL","MASTER_ID":28923,"ecocyc":"TRANS-RXN-56","compounds":"H(+)(out) + L-phenylalanine(out) => H(+)(in) + L-phenylalanine(in)"}
{"X":21298,"RHEA_ID":18281,"DIRECTION":"UN","MASTER_ID":18281,"ec":"1.3.1.6","compounds":"NAD(+) + succinate = fumarate + H(+) + NADH"}
{"X":21299,"RHEA_ID":18282,"compounds":"NAD(+) + succinate => fumarate + H(+) + NADH"}
{"X":21300,"RHEA_ID":18283,"compounds":"fumarate + H(+) + NADH => NAD(+) + succinate"}
{"X":21301,"RHEA_ID":28929,"compounds":"(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + 2 H(+) => 3,4,5-trihydroxybenzoate + O2"}
{"X":21302,"RHEA_ID":18285,"DIRECTION":"UN","MASTER_ID":18285,"ec":"3.5.1.83","metacyc":"3.5.1.83-RXN","compounds":"an N-acyl-D-aspartate + H2O = a carboxylate + D-aspartate"}
{"X":21303,"RHEA_ID":18286,"compounds":"an N-acyl-D-aspartate + H2O => a carboxylate + D-aspartate"}
{"X":21304,"RHEA_ID":18287,"compounds":"a carboxylate + D-aspartate => an N-acyl-D-aspartate + H2O"}
{"X":21305,"RHEA_ID":18289,"DIRECTION":"UN","MASTER_ID":18289,"ec":"4.2.1.81","compounds":"(S,S)-tartrate = H2O + oxaloacetate"}
{"X":21306,"RHEA_ID":18290,"compounds":"(S,S)-tartrate => H2O + oxaloacetate"}
{"X":21307,"RHEA_ID":18291,"compounds":"H2O + oxaloacetate => (S,S)-tartrate"}
{"X":21308,"RHEA_ID":28937,"compounds":"oxaloacetate + pyruvate => 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate"}
{"X":21309,"RHEA_ID":18293,"DIRECTION":"UN","MASTER_ID":18293,"ec":"6.2.1.8","compounds":"ATP + CoA + oxalate = AMP + diphosphate + oxalyl-CoA"}
{"X":21310,"RHEA_ID":18294,"DIRECTION":"LR","MASTER_ID":18293,"metacyc":"OXALATE--COA-LIGASE-RXN","compounds":"ATP + CoA + oxalate => AMP + diphosphate + oxalyl-CoA"}
{"X":21311,"RHEA_ID":18295,"compounds":"AMP + diphosphate + oxalyl-CoA => ATP + CoA + oxalate"}
{"X":21312,"RHEA_ID":28941,"DIRECTION":"RL","MASTER_ID":28939,"ecocyc":"TRANS-RXN-31","compounds":"H(+)(out) + xanthosine(out) => H(+)(in) + xanthosine(in)"}
{"X":21313,"RHEA_ID":18297,"DIRECTION":"UN","MASTER_ID":18297,"ec":"3.5.1.79","compounds":"a phtalamide + H2O = a primary amine + phthalate"}
{"X":21314,"RHEA_ID":18298,"compounds":"a phtalamide + H2O => a primary amine + phthalate"}
{"X":21315,"RHEA_ID":18299,"compounds":"a primary amine + phthalate => a phtalamide + H2O"}
{"X":21316,"RHEA_ID":18301,"compounds":"ATP + NH4(+) + XMP = AMP + diphosphate + GMP + 2 H(+)"}
{"X":21317,"RHEA_ID":18302,"DIRECTION":"LR","MASTER_ID":18301,"ecocyc":"GMP-SYN-NH3-RXN","metacyc":"GMP-SYN-NH3-RXN","compounds":"ATP + NH4(+) + XMP => AMP + diphosphate + GMP + 2 H(+)"}
{"X":21318,"RHEA_ID":18303,"compounds":"AMP + diphosphate + GMP + 2 H(+) => ATP + NH4(+) + XMP"}
{"X":21319,"RHEA_ID":28949,"DIRECTION":"RL","MASTER_ID":28947,"ecocyc":"TRANS-RXN-40","compounds":"H(+)(in) + L-arabinose(out) => H(+)(out) + L-arabinose(in)"}
{"X":21320,"RHEA_ID":18305,"DIRECTION":"UN","MASTER_ID":18305,"ec":"2.3.1.44","compounds":"acetyl-CoA + N-acetylneuraminate = CoA + N-acetyl-4-O-acetylneuraminate"}
{"X":21321,"RHEA_ID":18306,"DIRECTION":"LR","MASTER_ID":18305,"metacyc":"2.3.1.44-RXN","compounds":"acetyl-CoA + N-acetylneuraminate => CoA + N-acetyl-4-O-acetylneuraminate"}
{"X":21322,"RHEA_ID":18307,"compounds":"CoA + N-acetyl-4-O-acetylneuraminate => acetyl-CoA + N-acetylneuraminate"}
{"X":21323,"RHEA_ID":28953,"DIRECTION":"RL","MASTER_ID":28951,"ecocyc":"TRANS-RXN-10","compounds":"H(+)(out) + L-arabinose(out) => H(+)(in) + L-arabinose(in)"}
{"X":21324,"RHEA_ID":18309,"DIRECTION":"UN","MASTER_ID":18309,"ec":"3.5.1.81","compounds":"an N-acyl-D-amino acid + H2O = a carboxylate + a D-alpha-amino acid"}
{"X":21325,"RHEA_ID":18310,"compounds":"an N-acyl-D-amino acid + H2O => a carboxylate + a D-alpha-amino acid"}
{"X":21326,"RHEA_ID":18311,"compounds":"a carboxylate + a D-alpha-amino acid => an N-acyl-D-amino acid + H2O"}
{"X":21327,"RHEA_ID":18313,"DIRECTION":"UN","MASTER_ID":18313,"ec":"4.1.2.10","compounds":"(R)-mandelonitrile = benzaldehyde + hydrogen cyanide"}
{"X":21328,"RHEA_ID":18314,"DIRECTION":"LR","MASTER_ID":18313,"metacyc":"MANDELONITRILE-LYASE-RXN","compounds":"(R)-mandelonitrile => benzaldehyde + hydrogen cyanide"}
{"X":21329,"RHEA_ID":18315,"compounds":"benzaldehyde + hydrogen cyanide => (R)-mandelonitrile"}
{"X":21330,"RHEA_ID":28961,"DIRECTION":"RL","MASTER_ID":28959,"ecocyc":"TRANS-RXN-30","compounds":"D-xylose(out) + H(+)(out) => D-xylose(in) + H(+)(in)"}
{"X":21331,"RHEA_ID":18317,"DIRECTION":"UN","MASTER_ID":18317,"ec":"5.1.1.10","metacyc":"AMINO-ACID-RACEMASE-RXN","compounds":"an L-alpha-amino acid = a D-alpha-amino acid"}
{"X":21332,"RHEA_ID":18318,"compounds":"an L-alpha-amino acid => a D-alpha-amino acid"}
{"X":21333,"RHEA_ID":18319,"compounds":"a D-alpha-amino acid => an L-alpha-amino acid"}
{"X":21334,"RHEA_ID":18321,"DIRECTION":"UN","MASTER_ID":18321,"ec":"2.6.1.6","compounds":"2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate"}
{"X":21335,"RHEA_ID":18321,"DIRECTION":"UN","MASTER_ID":18321,"ec":"2.6.1.42","compounds":"2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate"}
{"X":21336,"RHEA_ID":18322,"compounds":"2-oxoglutarate + L-leucine => 4-methyl-2-oxopentanoate + L-glutamate"}
{"X":21337,"RHEA_ID":18323,"compounds":"4-methyl-2-oxopentanoate + L-glutamate => 2-oxoglutarate + L-leucine"}
{"X":21338,"RHEA_ID":28968,"DIRECTION":"LR","MASTER_ID":28967,"reactome":"R-HSA-352108.1","compounds":"L-proline(in) + Na(+)(in) => L-proline(out) + Na(+)(out)"}
{"X":21339,"RHEA_ID":18325,"DIRECTION":"UN","MASTER_ID":18325,"ec":"4.2.3.24","compounds":"(2E,6E)-farnesyl diphosphate = (+)-amorpha-4,11-diene + diphosphate"}
{"X":21340,"RHEA_ID":18326,"DIRECTION":"LR","MASTER_ID":18325,"metacyc":"RXN-8046","compounds":"(2E,6E)-farnesyl diphosphate => (+)-amorpha-4,11-diene + diphosphate"}
{"X":21341,"RHEA_ID":18327,"compounds":"(+)-amorpha-4,11-diene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":21342,"RHEA_ID":28971,"compounds":"H(+)(in) + shikimate(in) = H(+)(out) + shikimate(out)"}
{"X":21343,"RHEA_ID":18329,"DIRECTION":"UN","MASTER_ID":18329,"ec":"1.1.1.228","metacyc":"%2b-SABINOL-DEHYDROGENASE-RXN","compounds":"(1S,3R,5S)-sabinol + NAD(+) = (1S,5S)-sabinone + H(+) + NADH"}
{"X":21344,"RHEA_ID":18330,"compounds":"(1S,3R,5S)-sabinol + NAD(+) => (1S,5S)-sabinone + H(+) + NADH"}
{"X":21345,"RHEA_ID":18331,"compounds":"(1S,5S)-sabinone + H(+) + NADH => (1S,3R,5S)-sabinol + NAD(+)"}
{"X":21346,"RHEA_ID":28975,"compounds":"H(+)(out) + L-asparagine(in) = H(+)(in) + L-asparagine(out)"}
{"X":21347,"RHEA_ID":18333,"DIRECTION":"UN","MASTER_ID":18333,"ec":"2.7.1.136","metacyc":"MACROLIDE-2-KINASE-RXN","compounds":"ATP + oleandomycin = ADP + H(+) + oleandomycin 2'-O-phosphate"}
{"X":21348,"RHEA_ID":18334,"compounds":"ATP + oleandomycin => ADP + H(+) + oleandomycin 2'-O-phosphate"}
{"X":21349,"RHEA_ID":18335,"compounds":"ADP + H(+) + oleandomycin 2'-O-phosphate => ATP + oleandomycin"}
{"X":21350,"RHEA_ID":28979,"compounds":"H(+)(out) + nitrite(in) = H(+)(in) + nitrite(out)"}
{"X":21351,"RHEA_ID":18337,"DIRECTION":"UN","MASTER_ID":18337,"ec":"4.2.1.70","compounds":"D-ribose 5-phosphate + uracil = H2O + psi-UMP"}
{"X":21352,"RHEA_ID":18338,"compounds":"D-ribose 5-phosphate + uracil => H2O + psi-UMP"}
{"X":21353,"RHEA_ID":18339,"compounds":"H2O + psi-UMP => D-ribose 5-phosphate + uracil"}
{"X":21354,"RHEA_ID":28983,"compounds":"nitrite(in) = nitrite(out)"}
{"X":21355,"RHEA_ID":18341,"DIRECTION":"UN","MASTER_ID":18341,"ec":"3.1.1.68","compounds":"D-xylono-1,4-lactone + H2O = D-xylonate + H(+)"}
{"X":21356,"RHEA_ID":18342,"DIRECTION":"LR","MASTER_ID":18341,"metacyc":"XYLONO-14-LACTONASE-RXN","compounds":"D-xylono-1,4-lactone + H2O => D-xylonate + H(+)"}
{"X":21357,"RHEA_ID":18343,"compounds":"D-xylonate + H(+) => D-xylono-1,4-lactone + H2O"}
{"X":21358,"RHEA_ID":28987,"compounds":"H(+)(in) + N-acetylneuraminate(in) = H(+)(out) + N-acetylneuraminate(out)"}
{"X":21359,"RHEA_ID":18345,"DIRECTION":"UN","MASTER_ID":18345,"ec":"4.1.1.114","compounds":"a cis-3-alkyl-4-alkyloxetan-2-one = a cis-alkene + CO2"}
{"X":21360,"RHEA_ID":18346,"DIRECTION":"LR","MASTER_ID":18345,"metacyc":"RXN-18558","compounds":"a cis-3-alkyl-4-alkyloxetan-2-one => a cis-alkene + CO2"}
{"X":21361,"RHEA_ID":18347,"compounds":"a cis-alkene + CO2 => a cis-3-alkyl-4-alkyloxetan-2-one"}
{"X":21362,"RHEA_ID":18348,"compounds":"a cis-3-alkyl-4-alkyloxetan-2-one <=> a cis-alkene + CO2"}
{"X":21363,"RHEA_ID":18349,"DIRECTION":"UN","MASTER_ID":18349,"ec":"6.1.1.23","compounds":"ATP + L-aspartate + tRNA(Asx) = AMP + diphosphate + L-aspartyl-tRNA(Asx)"}
{"X":21364,"RHEA_ID":18350,"DIRECTION":"LR","MASTER_ID":18349,"metacyc":"6.1.1.23-RXN","compounds":"ATP + L-aspartate + tRNA(Asx) => AMP + diphosphate + L-aspartyl-tRNA(Asx)"}
{"X":21365,"RHEA_ID":18351,"compounds":"AMP + diphosphate + L-aspartyl-tRNA(Asx) => ATP + L-aspartate + tRNA(Asx)"}
{"X":21366,"RHEA_ID":28995,"compounds":"H(+)(out) + L-threonine(in) = H(+)(in) + L-threonine(out)"}
{"X":21367,"RHEA_ID":28996,"compounds":"H(+)(out) + L-threonine(in) => H(+)(in) + L-threonine(out)"}
{"X":21368,"RHEA_ID":18353,"DIRECTION":"UN","MASTER_ID":18353,"ec":"7.2.2.13","compounds":"ATP + H2O + K(+)(out) + Na(+)(in) = ADP + H(+) + K(+)(in) + Na(+)(out) + phosphate"}
{"X":21369,"RHEA_ID":18354,"DIRECTION":"LR","MASTER_ID":18353,"metacyc":"3.6.3.9-RXN","compounds":"ATP + H2O + K(+)(out) + Na(+)(in) => ADP + H(+) + K(+)(in) + Na(+)(out) + phosphate"}
{"X":21370,"RHEA_ID":18355,"compounds":"ADP + H(+) + K(+)(in) + Na(+)(out) + phosphate => ATP + H2O + K(+)(out) + Na(+)(in)"}
{"X":21371,"RHEA_ID":18356,"compounds":"ATP + H2O + K(+)(out) + Na(+)(in) <=> ADP + H(+) + K(+)(in) + Na(+)(out) + phosphate"}
{"X":21372,"RHEA_ID":18357,"DIRECTION":"UN","MASTER_ID":18357,"ec":"1.1.1.206","compounds":"NADP(+) + tropine = H(+) + NADPH + tropinone"}
{"X":21373,"RHEA_ID":18358,"compounds":"NADP(+) + tropine => H(+) + NADPH + tropinone"}
{"X":21374,"RHEA_ID":18359,"compounds":"H(+) + NADPH + tropinone => NADP(+) + tropine"}
{"X":21375,"RHEA_ID":29004,"DIRECTION":"LR","MASTER_ID":29003,"ecocyc":"TRANS-RXN-242","compounds":"H(+)(out) + L-homoserine(in) => H(+)(in) + L-homoserine(out)"}
{"X":21376,"RHEA_ID":18361,"DIRECTION":"UN","MASTER_ID":18361,"ec":"2.4.2.33","compounds":"dolichyl D-xylosyl phosphate + L-seryl-[protein] = 3-O-(beta-D-xylosyl)-L-seryl-[protein] + dolichyl phosphate + H(+)"}
{"X":21377,"RHEA_ID":18362,"compounds":"dolichyl D-xylosyl phosphate + L-seryl-[protein] => 3-O-(beta-D-xylosyl)-L-seryl-[protein] + dolichyl phosphate + H(+)"}
{"X":21378,"RHEA_ID":18363,"compounds":"3-O-(beta-D-xylosyl)-L-seryl-[protein] + dolichyl phosphate + H(+) => dolichyl D-xylosyl phosphate + L-seryl-[protein]"}
{"X":21379,"RHEA_ID":18365,"DIRECTION":"UN","MASTER_ID":18365,"ec":"1.1.1.83","compounds":"(R)-malate + NAD(+) = CO2 + NADH + pyruvate"}
{"X":21380,"RHEA_ID":18366,"DIRECTION":"LR","MASTER_ID":18365,"ecocyc":"1.1.1.83-RXN","metacyc":"1.1.1.83-RXN","compounds":"(R)-malate + NAD(+) => CO2 + NADH + pyruvate"}
{"X":21381,"RHEA_ID":18367,"compounds":"CO2 + NADH + pyruvate => (R)-malate + NAD(+)"}
{"X":21382,"RHEA_ID":29012,"compounds":"2-oxoglutarate(in) + H(+)(in) => 2-oxoglutarate(out) + H(+)(out)"}
{"X":21383,"RHEA_ID":18369,"DIRECTION":"UN","MASTER_ID":18369,"ec":"1.1.3.21","compounds":"O2 + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H2O2"}
{"X":21384,"RHEA_ID":18370,"DIRECTION":"LR","MASTER_ID":18369,"metacyc":"GLYCEROL-3-PHOSPHATE-OXIDASE-RXN","compounds":"O2 + sn-glycerol 3-phosphate => dihydroxyacetone phosphate + H2O2"}
{"X":21385,"RHEA_ID":18371,"compounds":"dihydroxyacetone phosphate + H2O2 => O2 + sn-glycerol 3-phosphate"}
{"X":21386,"RHEA_ID":29016,"compounds":"phosphate(out) + sn-glycerol 3-phosphate(in) => phosphate(in) + sn-glycerol 3-phosphate(out)"}
{"X":21387,"RHEA_ID":18373,"DIRECTION":"UN","MASTER_ID":18373,"ec":"2.7.1.154","compounds":"1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)"}
{"X":21388,"RHEA_ID":18374,"DIRECTION":"LR","MASTER_ID":18373,"metacyc":"2.7.1.154-RXN","compounds":"1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)"}
{"X":21389,"RHEA_ID":18375,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+) => 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP"}
{"X":21390,"RHEA_ID":29020,"compounds":"D-galactose(in) + H(+)(in) => D-galactose(out) + H(+)(out)"}
{"X":21391,"RHEA_ID":18377,"DIRECTION":"UN","MASTER_ID":18377,"ec":"2.7.1.87","compounds":"ATP + streptomycin = ADP + H(+) + streptomycin 3''-phosphate"}
{"X":21392,"RHEA_ID":18378,"compounds":"ATP + streptomycin => ADP + H(+) + streptomycin 3''-phosphate"}
{"X":21393,"RHEA_ID":18379,"compounds":"ADP + H(+) + streptomycin 3''-phosphate => ATP + streptomycin"}
{"X":21394,"RHEA_ID":29024,"compounds":"H(+)(in) + L-fucose(in) => H(+)(out) + L-fucose(out)"}
{"X":21395,"RHEA_ID":18381,"DIRECTION":"UN","MASTER_ID":18381,"ec":"2.7.1.121","compounds":"dihydroxyacetone + phosphoenolpyruvate = dihydroxyacetone phosphate + pyruvate"}
{"X":21396,"RHEA_ID":18382,"DIRECTION":"LR","MASTER_ID":18381,"ecocyc":"2.7.1.121-RXN","metacyc":"2.7.1.121-RXN","compounds":"dihydroxyacetone + phosphoenolpyruvate => dihydroxyacetone phosphate + pyruvate"}
{"X":21397,"RHEA_ID":18383,"compounds":"dihydroxyacetone phosphate + pyruvate => dihydroxyacetone + phosphoenolpyruvate"}
{"X":21398,"RHEA_ID":29028,"compounds":"2 H(+)(in) + L-glutamate(in) => 2 H(+)(out) + L-glutamate(out)"}
{"X":21399,"RHEA_ID":18385,"DIRECTION":"UN","MASTER_ID":18385,"ec":"6.4.1.6","compounds":"acetone + ATP + CO2 + 2 H2O = acetoacetate + AMP + 3 H(+) + 2 phosphate"}
{"X":21400,"RHEA_ID":18386,"DIRECTION":"LR","MASTER_ID":18385,"metacyc":"6.4.1.6-RXN","compounds":"acetone + ATP + CO2 + 2 H2O => acetoacetate + AMP + 3 H(+) + 2 phosphate"}
{"X":21401,"RHEA_ID":18387,"compounds":"acetoacetate + AMP + 3 H(+) + 2 phosphate => acetone + ATP + CO2 + 2 H2O"}
{"X":21402,"RHEA_ID":29032,"compounds":"L-glutamate(in) + Na(+)(in) => L-glutamate(out) + Na(+)(out)"}
{"X":21403,"RHEA_ID":18389,"DIRECTION":"UN","MASTER_ID":18389,"ec":"2.7.7.11","compounds":"alpha-D-xylose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-xylose"}
{"X":21404,"RHEA_ID":18390,"compounds":"alpha-D-xylose 1-phosphate + H(+) + UTP => diphosphate + UDP-alpha-D-xylose"}
{"X":21405,"RHEA_ID":18391,"compounds":"diphosphate + UDP-alpha-D-xylose => alpha-D-xylose 1-phosphate + H(+) + UTP"}
{"X":21406,"RHEA_ID":29036,"DIRECTION":"LR","MASTER_ID":29035,"ecocyc":"ABC-13-RXN","compounds":"ATP + H2O + L-glutamate(out) => ADP + H(+) + L-glutamate(in) + phosphate"}
{"X":21407,"RHEA_ID":18393,"DIRECTION":"UN","MASTER_ID":18393,"ec":"2.6.1.40","compounds":"(R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine"}
{"X":21408,"RHEA_ID":18394,"DIRECTION":"LR","MASTER_ID":18393,"reactome":"R-HSA-909780.1","compounds":"(R)-3-amino-2-methylpropanoate + pyruvate => 2-methyl-3-oxopropanoate + L-alanine"}
{"X":21409,"RHEA_ID":18395,"compounds":"2-methyl-3-oxopropanoate + L-alanine => (R)-3-amino-2-methylpropanoate + pyruvate"}
{"X":21410,"RHEA_ID":29040,"DIRECTION":"LR","MASTER_ID":29039,"ecocyc":"TRANS-RXN0-222","metacyc":"TRANS-RXN0-222","compounds":"ATP + H2O + L-aspartate(out) => ADP + H(+) + L-aspartate(in) + phosphate"}
{"X":21411,"RHEA_ID":18397,"DIRECTION":"UN","MASTER_ID":18397,"ec":"6.1.1.24","compounds":"ATP + L-glutamate + tRNA(Glx) = AMP + diphosphate + L-glutamyl-tRNA(Glx)"}
{"X":21412,"RHEA_ID":18398,"DIRECTION":"LR","MASTER_ID":18397,"metacyc":"6.1.1.24-RXN","compounds":"ATP + L-glutamate + tRNA(Glx) => AMP + diphosphate + L-glutamyl-tRNA(Glx)"}
{"X":21413,"RHEA_ID":18399,"compounds":"AMP + diphosphate + L-glutamyl-tRNA(Glx) => ATP + L-glutamate + tRNA(Glx)"}
{"X":21414,"RHEA_ID":29044,"DIRECTION":"LR","MASTER_ID":29043,"metacyc":"RXN-8850","compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH => (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+)"}
{"X":21415,"RHEA_ID":29045,"compounds":"(6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH"}
{"X":21416,"RHEA_ID":18401,"DIRECTION":"UN","MASTER_ID":18401,"ec":"1.14.14.37","compounds":"(E)-4-hydroxyphenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] = (S)-4-hydroxymandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":21417,"RHEA_ID":18402,"DIRECTION":"LR","MASTER_ID":18401,"metacyc":"1.14.13.68-RXN","compounds":"(E)-4-hydroxyphenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] => (S)-4-hydroxymandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":21418,"RHEA_ID":18403,"compounds":"(S)-4-hydroxymandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (E)-4-hydroxyphenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":21419,"RHEA_ID":29049,"compounds":"a menaquinol + 2 H(+)(out) => a menaquinone + 2 H(+)(in) + H2"}
{"X":21420,"RHEA_ID":18405,"DIRECTION":"UN","MASTER_ID":18405,"ec":"1.4.1.1","compounds":"H2O + L-alanine + NAD(+) = H(+) + NADH + NH4(+) + pyruvate"}
{"X":21421,"RHEA_ID":18406,"DIRECTION":"LR","MASTER_ID":18405,"macie":"M0067","compounds":"H2O + L-alanine + NAD(+) => H(+) + NADH + NH4(+) + pyruvate"}
{"X":21422,"RHEA_ID":18407,"compounds":"H(+) + NADH + NH4(+) + pyruvate => H2O + L-alanine + NAD(+)"}
{"X":21423,"RHEA_ID":18409,"DIRECTION":"UN","MASTER_ID":18409,"ec":"1.1.1.270","compounds":"4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH"}
{"X":21424,"RHEA_ID":18410,"compounds":"4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) => 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH"}
{"X":21425,"RHEA_ID":18411,"compounds":"4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH => 4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+)"}
{"X":21426,"RHEA_ID":29057,"compounds":"a ubiquinol + 2 H(+)(out) => a ubiquinone + 2 H(+)(in) + H2"}
{"X":21427,"RHEA_ID":18413,"DIRECTION":"UN","MASTER_ID":18413,"ec":"2.4.1.179","metacyc":"2.4.1.179-RXN","compounds":"a beta-D-galactosyl-(1->4)-beta-D-glucosyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosaminyl derivative + H(+) + UDP"}
{"X":21428,"RHEA_ID":18414,"compounds":"a beta-D-galactosyl-(1->4)-beta-D-glucosyl derivative + UDP-alpha-D-galactose => a beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosaminyl derivative + H(+) + UDP"}
{"X":21429,"RHEA_ID":18415,"compounds":"a beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosaminyl derivative + H(+) + UDP => a beta-D-galactosyl-(1->4)-beta-D-glucosyl derivative + UDP-alpha-D-galactose"}
{"X":21430,"RHEA_ID":29061,"compounds":"2 H(+)(out) + ubiquinol-8 => 2 H(+)(in) + H2 + ubiquinone-8"}
{"X":21431,"RHEA_ID":18417,"DIRECTION":"UN","MASTER_ID":18417,"ec":"2.4.99.9","compounds":"a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = CMP + ganglioside GM3 (d18:1(4E)) + H(+)"}
{"X":21432,"RHEA_ID":18418,"compounds":"a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => CMP + ganglioside GM3 (d18:1(4E)) + H(+)"}
{"X":21433,"RHEA_ID":18419,"compounds":"CMP + ganglioside GM3 (d18:1(4E)) + H(+) => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate"}
{"X":21434,"RHEA_ID":29065,"compounds":"a menaquinol + CO2 => a menaquinone + formate + H(+)"}
{"X":21435,"RHEA_ID":18421,"DIRECTION":"UN","MASTER_ID":18421,"ec":"2.3.1.28","compounds":"acetyl-CoA + chloramphenicol = chloramphenicol 3-acetate + CoA"}
{"X":21436,"RHEA_ID":18422,"compounds":"acetyl-CoA + chloramphenicol => chloramphenicol 3-acetate + CoA"}
{"X":21437,"RHEA_ID":18423,"compounds":"chloramphenicol 3-acetate + CoA => acetyl-CoA + chloramphenicol"}
{"X":21438,"RHEA_ID":29069,"compounds":"CO2 + menaquinol-8 => formate + H(+) + menaquinone-8"}
{"X":21439,"RHEA_ID":18425,"DIRECTION":"UN","MASTER_ID":18425,"ec":"1.1.1.282","compounds":"L-quinate + NADP(+) = 3-dehydroquinate + H(+) + NADPH"}
{"X":21440,"RHEA_ID":18426,"DIRECTION":"LR","MASTER_ID":18425,"ecocyc":"RXN-7967","metacyc":"RXN-7967","compounds":"L-quinate + NADP(+) => 3-dehydroquinate + H(+) + NADPH"}
{"X":21441,"RHEA_ID":18427,"compounds":"3-dehydroquinate + H(+) + NADPH => L-quinate + NADP(+)"}
{"X":21442,"RHEA_ID":29073,"compounds":"a ubiquinol + CO2 => a ubiquinone + formate + H(+)"}
{"X":21443,"RHEA_ID":18433,"DIRECTION":"UN","MASTER_ID":18433,"ec":"1.4.3.12","compounds":"cyclohexylamine + H2O + O2 = cyclohexanone + H2O2 + NH4(+)"}
{"X":21444,"RHEA_ID":18434,"DIRECTION":"LR","MASTER_ID":18433,"metacyc":"CYCLOHEXYLAMINE-OXIDASE-RXN","compounds":"cyclohexylamine + H2O + O2 => cyclohexanone + H2O2 + NH4(+)"}
{"X":21445,"RHEA_ID":18435,"compounds":"cyclohexanone + H2O2 + NH4(+) => cyclohexylamine + H2O + O2"}
{"X":21446,"RHEA_ID":18437,"DIRECTION":"UN","MASTER_ID":18437,"ec":"2.7.1.148","compounds":"4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)"}
{"X":21447,"RHEA_ID":18438,"DIRECTION":"LR","MASTER_ID":18437,"ecocyc":"2.7.1.148-RXN","metacyc":"2.7.1.148-RXN","compounds":"4-CDP-2-C-methyl-D-erythritol + ATP => 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)"}
{"X":21448,"RHEA_ID":18439,"compounds":"4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+) => 4-CDP-2-C-methyl-D-erythritol + ATP"}
{"X":21449,"RHEA_ID":29081,"compounds":"pyruvate + ubiquinol-8 => (R)-lactate + ubiquinone-8"}
{"X":21450,"RHEA_ID":18441,"DIRECTION":"UN","MASTER_ID":18441,"ec":"4.1.1.84","compounds":"D-dopachrome + H(+) = 5,6-dihydroxyindole + CO2"}
{"X":21451,"RHEA_ID":18442,"compounds":"D-dopachrome + H(+) => 5,6-dihydroxyindole + CO2"}
{"X":21452,"RHEA_ID":18443,"compounds":"5,6-dihydroxyindole + CO2 => D-dopachrome + H(+)"}
{"X":21453,"RHEA_ID":29085,"compounds":"oxaloacetate + ubiquinol-8 => (S)-malate + ubiquinone-8"}
{"X":21454,"RHEA_ID":18445,"DIRECTION":"UN","MASTER_ID":18445,"ec":"3.5.4.10","compounds":"H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide"}
{"X":21455,"RHEA_ID":18446,"compounds":"H2O + IMP => 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide"}
{"X":21456,"RHEA_ID":18447,"DIRECTION":"RL","MASTER_ID":18445,"reactome":"R-HSA-73797.2","compounds":"5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide => H2O + IMP"}
{"X":21457,"RHEA_ID":29089,"compounds":"menaquinol-8 + oxaloacetate => (S)-malate + menaquinone-8"}
{"X":21458,"RHEA_ID":18449,"DIRECTION":"UN","MASTER_ID":18449,"ec":"1.20.99.1","compounds":"A + arsenite + H2O = AH2 + arsenate + H(+)"}
{"X":21459,"RHEA_ID":18450,"compounds":"A + arsenite + H2O => AH2 + arsenate + H(+)"}
{"X":21460,"RHEA_ID":18451,"compounds":"AH2 + arsenate + H(+) => A + arsenite + H2O"}
{"X":21461,"RHEA_ID":18453,"DIRECTION":"UN","MASTER_ID":18453,"ec":"7.5.2.3","compounds":"[(1->2)-beta-D-glucosyl](n)(in) + ATP + H2O = [(1->2)-beta-D-glucosyl](n)(out) + ADP + H(+) + phosphate"}
{"X":21462,"RHEA_ID":18454,"DIRECTION":"LR","MASTER_ID":18453,"metacyc":"3.6.3.42-RXN","compounds":"[(1->2)-beta-D-glucosyl](n)(in) + ATP + H2O => [(1->2)-beta-D-glucosyl](n)(out) + ADP + H(+) + phosphate"}
{"X":21463,"RHEA_ID":18455,"compounds":"[(1->2)-beta-D-glucosyl](n)(out) + ADP + H(+) + phosphate => [(1->2)-beta-D-glucosyl](n)(in) + ATP + H2O"}
{"X":21464,"RHEA_ID":18456,"compounds":"[(1->2)-beta-D-glucosyl](n)(in) + ATP + H2O <=> [(1->2)-beta-D-glucosyl](n)(out) + ADP + H(+) + phosphate"}
{"X":21465,"RHEA_ID":18457,"DIRECTION":"UN","MASTER_ID":18457,"ec":"4.1.99.12","compounds":"D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)"}
{"X":21466,"RHEA_ID":18458,"DIRECTION":"LR","MASTER_ID":18457,"ecocyc":"DIOHBUTANONEPSYN-RXN","metacyc":"DIOHBUTANONEPSYN-RXN","compounds":"D-ribulose 5-phosphate => (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)"}
{"X":21467,"RHEA_ID":18459,"compounds":"(2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+) => D-ribulose 5-phosphate"}
{"X":21468,"RHEA_ID":29101,"compounds":"a menaquinol + 4 H(+)(out) + NAD(+) => a menaquinone + 5 H(+)(in) + NADH"}
{"X":21469,"RHEA_ID":18461,"DIRECTION":"UN","MASTER_ID":18461,"ec":"2.3.1.67","compounds":"1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA"}
{"X":21470,"RHEA_ID":18462,"compounds":"1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA => 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA"}
{"X":21471,"RHEA_ID":18463,"compounds":"1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA => 1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA"}
{"X":21472,"RHEA_ID":29105,"compounds":"4 H(+)(out) + menaquinol-8 + NAD(+) => 5 H(+)(in) + menaquinone-8 + NADH"}
{"X":21473,"RHEA_ID":18465,"DIRECTION":"UN","MASTER_ID":18465,"ec":"1.13.11.30","compounds":"L-dopa + O2 = 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)"}
{"X":21474,"RHEA_ID":18466,"DIRECTION":"LR","MASTER_ID":18465,"metacyc":"STIZOLOBINATE-SYNTHASE-RXN","compounds":"L-dopa + O2 => 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)"}
{"X":21475,"RHEA_ID":18467,"compounds":"5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+) => L-dopa + O2"}
{"X":21476,"RHEA_ID":29109,"compounds":"NAD(+) + ubiquinol-8 => H(+) + NADH + ubiquinone-8"}
{"X":21477,"RHEA_ID":18469,"DIRECTION":"UN","MASTER_ID":18469,"ec":"2.3.1.68","compounds":"an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)"}
{"X":21478,"RHEA_ID":18470,"compounds":"an acyl-CoA + L-glutamine => an N(2)-acyl-L-glutamine + CoA + H(+)"}
{"X":21479,"RHEA_ID":18471,"compounds":"an N(2)-acyl-L-glutamine + CoA + H(+) => an acyl-CoA + L-glutamine"}
{"X":21480,"RHEA_ID":29113,"compounds":"NADP(+) + ubiquinol-8 => H(+) + NADPH + ubiquinone-8"}
{"X":21481,"RHEA_ID":18473,"DIRECTION":"UN","MASTER_ID":18473,"ec":"2.4.2.17","compounds":"1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP"}
{"X":21482,"RHEA_ID":18474,"compounds":"1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate => 5-phospho-alpha-D-ribose 1-diphosphate + ATP"}
{"X":21483,"RHEA_ID":18475,"compounds":"5-phospho-alpha-D-ribose 1-diphosphate + ATP => 1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate"}
{"X":21484,"RHEA_ID":29117,"compounds":"menaquinol-8 + NADP(+) => H(+) + menaquinone-8 + NADPH"}
{"X":21485,"RHEA_ID":18477,"DIRECTION":"UN","MASTER_ID":18477,"ec":"1.13.11.14","compounds":"2,3-dihydroxybenzoate + O2 = 2-hydroxy-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+)"}
{"X":21486,"RHEA_ID":18478,"DIRECTION":"LR","MASTER_ID":18477,"metacyc":"1.13.11.14-RXN","compounds":"2,3-dihydroxybenzoate + O2 => 2-hydroxy-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+)"}
{"X":21487,"RHEA_ID":18479,"compounds":"2-hydroxy-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+) => 2,3-dihydroxybenzoate + O2"}
{"X":21488,"RHEA_ID":29121,"compounds":"a ubiquinone + H2O + nitrite => a ubiquinol + nitrate"}
{"X":21489,"RHEA_ID":18481,"DIRECTION":"UN","MASTER_ID":18481,"ec":"3.10.1.2","metacyc":"CYCLAMATE-SULFOHYDROLASE-RXN","compounds":"cyclohexylsulfamate + H2O = cyclohexylamine + sulfate"}
{"X":21490,"RHEA_ID":18482,"compounds":"cyclohexylsulfamate + H2O => cyclohexylamine + sulfate"}
{"X":21491,"RHEA_ID":18483,"compounds":"cyclohexylamine + sulfate => cyclohexylsulfamate + H2O"}
{"X":21492,"RHEA_ID":18485,"DIRECTION":"UN","MASTER_ID":18485,"ec":"3.1.1.33","compounds":"6-acetyl-D-glucose + H2O = acetate + D-glucose + H(+)"}
{"X":21493,"RHEA_ID":18486,"DIRECTION":"LR","MASTER_ID":18485,"metacyc":"6-ACETYLGLUCOSE-DEACETYLASE-RXN","compounds":"6-acetyl-D-glucose + H2O => acetate + D-glucose + H(+)"}
{"X":21494,"RHEA_ID":18487,"compounds":"acetate + D-glucose + H(+) => 6-acetyl-D-glucose + H2O"}
{"X":21495,"RHEA_ID":29129,"compounds":"a menaquinone + H2O + nitrite => a menaquinol + nitrate"}
{"X":21496,"RHEA_ID":18489,"compounds":"cyanate + H(+) + hydrogencarbonate = carbamate + CO2"}
{"X":21497,"RHEA_ID":18490,"DIRECTION":"LR","MASTER_ID":18489,"ecocyc":"R524-RXN","metacyc":"R524-RXN","compounds":"cyanate + H(+) + hydrogencarbonate => carbamate + CO2"}
{"X":21498,"RHEA_ID":18491,"compounds":"carbamate + CO2 => cyanate + H(+) + hydrogencarbonate"}
{"X":21499,"RHEA_ID":18493,"DIRECTION":"UN","MASTER_ID":18493,"ec":"2.3.1.71","compounds":"benzoyl-CoA + glycine = CoA + H(+) + N-benzoylglycine"}
{"X":21500,"RHEA_ID":18494,"DIRECTION":"LR","MASTER_ID":18493,"metacyc":"GLYCINE-N-BENZOYLTRANSFERASE-RXN","reactome":"R-HSA-159566.2","compounds":"benzoyl-CoA + glycine => CoA + H(+) + N-benzoylglycine"}
{"X":21501,"RHEA_ID":18495,"compounds":"CoA + H(+) + N-benzoylglycine => benzoyl-CoA + glycine"}
{"X":21502,"RHEA_ID":29137,"compounds":"a menaquinone + 2 H(+)(out) + H2O + nitrite => a menaquinol + 2 H(+)(in) + nitrate"}
{"X":21503,"RHEA_ID":18497,"DIRECTION":"UN","MASTER_ID":18497,"ec":"5.1.3.22","compounds":"L-ribulose 5-phosphate = L-xylulose 5-phosphate"}
{"X":21504,"RHEA_ID":18498,"compounds":"L-ribulose 5-phosphate => L-xylulose 5-phosphate"}
{"X":21505,"RHEA_ID":18499,"DIRECTION":"RL","MASTER_ID":18497,"ecocyc":"LXULRU5P-RXN","metacyc":"LXULRU5P-RXN","compounds":"L-xylulose 5-phosphate => L-ribulose 5-phosphate"}
{"X":21506,"RHEA_ID":29141,"compounds":"2 H(+)(out) + H2O + menaquinone-8 + nitrite => 2 H(+)(in) + menaquinol-8 + nitrate"}
{"X":21507,"RHEA_ID":18501,"DIRECTION":"UN","MASTER_ID":18501,"ec":"1.3.1.71","compounds":"ergosterol + NADP(+) = ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+) + NADPH"}
{"X":21508,"RHEA_ID":18502,"compounds":"ergosterol + NADP(+) => ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+) + NADPH"}
{"X":21509,"RHEA_ID":18503,"DIRECTION":"RL","MASTER_ID":18501,"metacyc":"1.3.1.71-RXN","compounds":"ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+) + NADPH => ergosterol + NADP(+)"}
{"X":21510,"RHEA_ID":29145,"compounds":"a ubiquinone + 2 H(+)(out) + H2O + nitrite => a ubiquinol + 2 H(+)(in) + nitrate"}
{"X":21511,"RHEA_ID":18505,"DIRECTION":"UN","MASTER_ID":18505,"ec":"1.4.1.15","compounds":"L-lysine + NAD(+) = Delta(1)-piperideine-2-carboxylate + H(+) + NADH + NH4(+)"}
{"X":21512,"RHEA_ID":18506,"DIRECTION":"LR","MASTER_ID":18505,"metacyc":"LYSINE-DEHYDROGENASE-RXN","compounds":"L-lysine + NAD(+) => Delta(1)-piperideine-2-carboxylate + H(+) + NADH + NH4(+)"}
{"X":21513,"RHEA_ID":18507,"compounds":"Delta(1)-piperideine-2-carboxylate + H(+) + NADH + NH4(+) => L-lysine + NAD(+)"}
{"X":21514,"RHEA_ID":29149,"compounds":"2 H(+)(out) + H2O + nitrite + ubiquinone-8 => 2 H(+)(in) + nitrate + ubiquinol-8"}
{"X":21515,"RHEA_ID":18509,"DIRECTION":"UN","MASTER_ID":18509,"ec":"1.11.1.1","compounds":"H(+) + H2O2 + NADH = 2 H2O + NAD(+)"}
{"X":21516,"RHEA_ID":18510,"compounds":"H(+) + H2O2 + NADH => 2 H2O + NAD(+)"}
{"X":21517,"RHEA_ID":18511,"compounds":"2 H2O + NAD(+) => H(+) + H2O2 + NADH"}
{"X":21518,"RHEA_ID":18513,"DIRECTION":"UN","MASTER_ID":18513,"ec":"1.1.3.40","compounds":"D-mannitol + O2 = D-mannose + H2O2"}
{"X":21519,"RHEA_ID":18514,"DIRECTION":"LR","MASTER_ID":18513,"metacyc":"1.1.3.40-RXN","compounds":"D-mannitol + O2 => D-mannose + H2O2"}
{"X":21520,"RHEA_ID":18515,"compounds":"D-mannose + H2O2 => D-mannitol + O2"}
{"X":21521,"RHEA_ID":29157,"compounds":"2 H2O(out) + NH4(+)(out) + 3 ubiquinone-8(in) => 2 H(+)(out) + nitrite(out) + 3 ubiquinol-8(in)"}
{"X":21522,"RHEA_ID":18521,"DIRECTION":"UN","MASTER_ID":18521,"ec":"2.1.1.65","compounds":"licodione + S-adenosyl-L-methionine = 2'-O-methyllicodione + H(+) + S-adenosyl-L-homocysteine"}
{"X":21523,"RHEA_ID":18522,"DIRECTION":"LR","MASTER_ID":18521,"metacyc":"LICODIONE-2-O-METHYLTRANSFERASE-RXN","compounds":"licodione + S-adenosyl-L-methionine => 2'-O-methyllicodione + H(+) + S-adenosyl-L-homocysteine"}
{"X":21524,"RHEA_ID":18523,"compounds":"2'-O-methyllicodione + H(+) + S-adenosyl-L-homocysteine => licodione + S-adenosyl-L-methionine"}
{"X":21525,"RHEA_ID":29161,"compounds":"3 a menaquinone(in) + 2 H2O(out) + NH4(+)(out) => 3 a menaquinol(in) + 2 H(+)(out) + nitrite(out)"}
{"X":21526,"RHEA_ID":18525,"DIRECTION":"UN","MASTER_ID":18525,"ec":"1.1.1.265","compounds":"3-methylbutanol + NADP(+) = 3-methylbutanal + H(+) + NADPH"}
{"X":21527,"RHEA_ID":18526,"compounds":"3-methylbutanol + NADP(+) => 3-methylbutanal + H(+) + NADPH"}
{"X":21528,"RHEA_ID":18527,"DIRECTION":"RL","MASTER_ID":18525,"metacyc":"1.1.1.265-RXN","compounds":"3-methylbutanal + H(+) + NADPH => 3-methylbutanol + NADP(+)"}
{"X":21529,"RHEA_ID":18529,"DIRECTION":"UN","MASTER_ID":18529,"ec":"1.1.1.265","compounds":"3-methylbutanol + NAD(+) = 3-methylbutanal + H(+) + NADH"}
{"X":21530,"RHEA_ID":18530,"compounds":"3-methylbutanol + NAD(+) => 3-methylbutanal + H(+) + NADH"}
{"X":21531,"RHEA_ID":18531,"DIRECTION":"RL","MASTER_ID":18529,"metacyc":"1.1.1.265-RXN","compounds":"3-methylbutanal + H(+) + NADH => 3-methylbutanol + NAD(+)"}
{"X":21532,"RHEA_ID":18533,"DIRECTION":"UN","MASTER_ID":18533,"ec":"4.1.1.28","compounds":"5-hydroxy-L-tryptophan + H(+) = CO2 + serotonin"}
{"X":21533,"RHEA_ID":18534,"DIRECTION":"LR","MASTER_ID":18533,"metacyc":"RXN3DJ-170","reactome":"R-HSA-209859.1","compounds":"5-hydroxy-L-tryptophan + H(+) => CO2 + serotonin"}
{"X":21534,"RHEA_ID":18535,"compounds":"CO2 + serotonin => 5-hydroxy-L-tryptophan + H(+)"}
{"X":21535,"RHEA_ID":29173,"DIRECTION":"RL","MASTER_ID":29171,"ecocyc":"RXN-20148","metacyc":"RXN-20148","compounds":"a ubiquinone + 2 H(+) + 2 superoxide => a ubiquinol + 2 O2"}
{"X":21536,"RHEA_ID":18537,"DIRECTION":"UN","MASTER_ID":18537,"ec":"1.2.1.65","compounds":"H2O + NAD(+) + salicylaldehyde = 2 H(+) + NADH + salicylate"}
{"X":21537,"RHEA_ID":18538,"DIRECTION":"LR","MASTER_ID":18537,"metacyc":"1.2.1.65-RXN","compounds":"H2O + NAD(+) + salicylaldehyde => 2 H(+) + NADH + salicylate"}
{"X":21538,"RHEA_ID":18539,"compounds":"2 H(+) + NADH + salicylate => H2O + NAD(+) + salicylaldehyde"}
{"X":21539,"RHEA_ID":29177,"compounds":"2 H(+) + 2 superoxide + ubiquinone-8 => 2 O2 + ubiquinol-8"}
{"X":21540,"RHEA_ID":18541,"DIRECTION":"UN","MASTER_ID":18541,"ec":"2.1.1.119","compounds":"10-hydroxydihydrosanguinarine + S-adenosyl-L-methionine = dihydrochelirubine + H(+) + S-adenosyl-L-homocysteine"}
{"X":21541,"RHEA_ID":18542,"DIRECTION":"LR","MASTER_ID":18541,"metacyc":"2.1.1.119-RXN","compounds":"10-hydroxydihydrosanguinarine + S-adenosyl-L-methionine => dihydrochelirubine + H(+) + S-adenosyl-L-homocysteine"}
{"X":21542,"RHEA_ID":18543,"compounds":"dihydrochelirubine + H(+) + S-adenosyl-L-homocysteine => 10-hydroxydihydrosanguinarine + S-adenosyl-L-methionine"}
{"X":21543,"RHEA_ID":29181,"compounds":"a menaquinone + 2 H(+) + 2 superoxide => a menaquinol + 2 O2"}
{"X":21544,"RHEA_ID":18545,"DIRECTION":"UN","MASTER_ID":18545,"ec":"4.1.2.18","compounds":"2-dehydro-3-deoxy-L-arabinonate = glycolaldehyde + pyruvate"}
{"X":21545,"RHEA_ID":18546,"compounds":"2-dehydro-3-deoxy-L-arabinonate => glycolaldehyde + pyruvate"}
{"X":21546,"RHEA_ID":18547,"compounds":"glycolaldehyde + pyruvate => 2-dehydro-3-deoxy-L-arabinonate"}
{"X":21547,"RHEA_ID":18549,"DIRECTION":"UN","MASTER_ID":18549,"ec":"2.4.1.11","compounds":"[(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->4)-alpha-D-glucosyl](n+1) + H(+) + UDP"}
{"X":21548,"RHEA_ID":18550,"DIRECTION":"LR","MASTER_ID":18549,"metacyc":"RXN-7668","compounds":"[(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose => [(1->4)-alpha-D-glucosyl](n+1) + H(+) + UDP"}
{"X":21549,"RHEA_ID":18551,"compounds":"[(1->4)-alpha-D-glucosyl](n+1) + H(+) + UDP => [(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose"}
{"X":21550,"RHEA_ID":29189,"compounds":"fumarate + ubiquinol-8 => succinate + ubiquinone-8"}
{"X":21551,"RHEA_ID":18553,"DIRECTION":"UN","MASTER_ID":18553,"ec":"1.3.1.7","metacyc":"MESO-TARTRATE-DEHYDROGENASE-RXN","compounds":"(2R,3S)-tartrate + NAD(+) = dihydroxyfumarate + H(+) + NADH"}
{"X":21552,"RHEA_ID":18554,"compounds":"(2R,3S)-tartrate + NAD(+) => dihydroxyfumarate + H(+) + NADH"}
{"X":21553,"RHEA_ID":18555,"compounds":"dihydroxyfumarate + H(+) + NADH => (2R,3S)-tartrate + NAD(+)"}
{"X":21554,"RHEA_ID":29194,"compounds":"L-aspartate + menaquinone-8 <=> iminosuccinate + menaquinol-8"}
{"X":21555,"RHEA_ID":18557,"DIRECTION":"UN","MASTER_ID":18557,"ec":"2.3.1.105","compounds":"1-O-alkyl-sn-glycero-3-phosphate + acetyl-CoA = 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA"}
{"X":21556,"RHEA_ID":18558,"DIRECTION":"LR","MASTER_ID":18557,"metacyc":"2.3.1.105-RXN","compounds":"1-O-alkyl-sn-glycero-3-phosphate + acetyl-CoA => 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA"}
{"X":21557,"RHEA_ID":18559,"compounds":"1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA => 1-O-alkyl-sn-glycero-3-phosphate + acetyl-CoA"}
{"X":21558,"RHEA_ID":29198,"compounds":"(S)-dihydroorotate + a menaquinone <=> a menaquinol + orotate"}
{"X":21559,"RHEA_ID":18561,"DIRECTION":"UN","MASTER_ID":18561,"ec":"1.3.1.70","compounds":"4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + H(+) + NADPH"}
{"X":21560,"RHEA_ID":18562,"compounds":"4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) => 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + H(+) + NADPH"}
{"X":21561,"RHEA_ID":18563,"DIRECTION":"RL","MASTER_ID":18561,"metacyc":"1.3.1.70-RXN","reactome":"R-HSA-194674.1","compounds":"4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + H(+) + NADPH => 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+)"}
{"X":21562,"RHEA_ID":29202,"compounds":"(S)-dihydroorotate + menaquinone-8 <=> menaquinol-8 + orotate"}
{"X":21563,"RHEA_ID":18565,"DIRECTION":"UN","MASTER_ID":18565,"ec":"2.3.1.161","compounds":"19 H(+) + holo-[lovastatin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine = 9 CO2 + 9 CoA + dihydromonacolin L-[lovastatin nonaketide synthase] + 6 H2O + 11 NADP(+) + S-adenosyl-L-homocysteine"}
{"X":21564,"RHEA_ID":18566,"DIRECTION":"LR","MASTER_ID":18565,"metacyc":"2.3.1.161-RXN","compounds":"19 H(+) + holo-[lovastatin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine => 9 CO2 + 9 CoA + dihydromonacolin L-[lovastatin nonaketide synthase] + 6 H2O + 11 NADP(+) + S-adenosyl-L-homocysteine"}
{"X":21565,"RHEA_ID":18567,"compounds":"9 CO2 + 9 CoA + dihydromonacolin L-[lovastatin nonaketide synthase] + 6 H2O + 11 NADP(+) + S-adenosyl-L-homocysteine => 19 H(+) + holo-[lovastatin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine"}
{"X":21566,"RHEA_ID":29206,"compounds":"dimethyl sulfoxide + menaquinol-8 <=> dimethyl sulfide + H2O + menaquinone-8"}
{"X":21567,"RHEA_ID":18569,"DIRECTION":"UN","MASTER_ID":18569,"ec":"1.2.3.9","compounds":"an aromatic aldehyde + H2O + O2 = an aromatic carboxylate + H(+) + H2O2"}
{"X":21568,"RHEA_ID":18570,"DIRECTION":"LR","MASTER_ID":18569,"metacyc":"ARYL-ALDEHYDE-OXIDASE-RXN","compounds":"an aromatic aldehyde + H2O + O2 => an aromatic carboxylate + H(+) + H2O2"}
{"X":21569,"RHEA_ID":18571,"compounds":"an aromatic carboxylate + H(+) + H2O2 => an aromatic aldehyde + H2O + O2"}
{"X":21570,"RHEA_ID":29210,"compounds":"a menaquinol(in) + dimethyl sulfoxide(out) <=> a menaquinone(in) + dimethyl sulfide(out) + H2O(out)"}
{"X":21571,"RHEA_ID":18573,"DIRECTION":"UN","MASTER_ID":18573,"ec":"1.5.3.12","compounds":"dihydrochelirubine + H(+) + O2 = chelirubine + H2O2"}
{"X":21572,"RHEA_ID":18574,"DIRECTION":"LR","MASTER_ID":18573,"metacyc":"RXN-9275","compounds":"dihydrochelirubine + H(+) + O2 => chelirubine + H2O2"}
{"X":21573,"RHEA_ID":18575,"compounds":"chelirubine + H2O2 => dihydrochelirubine + H(+) + O2"}
{"X":21574,"RHEA_ID":18577,"DIRECTION":"UN","MASTER_ID":18577,"ec":"2.1.1.302","compounds":"3-hydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine = 3-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine"}
{"X":21575,"RHEA_ID":18578,"DIRECTION":"LR","MASTER_ID":18577,"metacyc":"RXN-15304","compounds":"3-hydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine => 3-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine"}
{"X":21576,"RHEA_ID":18579,"compounds":"3-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine => 3-hydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine"}
{"X":21577,"RHEA_ID":18580,"compounds":"3-hydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine <=> 3-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine"}
{"X":21578,"RHEA_ID":18581,"DIRECTION":"UN","MASTER_ID":18581,"ec":"1.4.3.8","compounds":"ethanolamine + H2O + O2 = glycolaldehyde + H2O2 + NH4(+)"}
{"X":21579,"RHEA_ID":18582,"DIRECTION":"LR","MASTER_ID":18581,"metacyc":"ETHANOLAMINE-OXIDASE-RXN","compounds":"ethanolamine + H2O + O2 => glycolaldehyde + H2O2 + NH4(+)"}
{"X":21580,"RHEA_ID":18583,"compounds":"glycolaldehyde + H2O2 + NH4(+) => ethanolamine + H2O + O2"}
{"X":21581,"RHEA_ID":18585,"DIRECTION":"UN","MASTER_ID":18585,"ec":"5.3.1.1","compounds":"D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate"}
{"X":21582,"RHEA_ID":18586,"DIRECTION":"LR","MASTER_ID":18585,"reactome":"R-HSA-70481.3","compounds":"D-glyceraldehyde 3-phosphate => dihydroxyacetone phosphate"}
{"X":21583,"RHEA_ID":18587,"DIRECTION":"RL","MASTER_ID":18585,"macie":"M0324","reactome":"R-HSA-70454.3","compounds":"dihydroxyacetone phosphate => D-glyceraldehyde 3-phosphate"}
{"X":21584,"RHEA_ID":29226,"compounds":"menaquinone-8 + sn-glycerol 3-phosphate <=> dihydroxyacetone phosphate + menaquinol-8"}
{"X":21585,"RHEA_ID":18589,"DIRECTION":"UN","MASTER_ID":18589,"ec":"2.7.7.42","compounds":"[glutamine synthetase]-L-tyrosine + ATP = [glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + diphosphate"}
{"X":21586,"RHEA_ID":18590,"DIRECTION":"LR","MASTER_ID":18589,"ecocyc":"GSADENYLATION-RXN","metacyc":"GSADENYLATION-RXN","compounds":"[glutamine synthetase]-L-tyrosine + ATP => [glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + diphosphate"}
{"X":21587,"RHEA_ID":18591,"compounds":"[glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + diphosphate => [glutamine synthetase]-L-tyrosine + ATP"}
{"X":21588,"RHEA_ID":18593,"DIRECTION":"UN","MASTER_ID":18593,"ec":"4.1.2.27","compounds":"sphinganine 1-phosphate = hexadecanal + phosphoethanolamine"}
{"X":21589,"RHEA_ID":18594,"DIRECTION":"LR","MASTER_ID":18593,"metacyc":"SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN","reactome":"R-HSA-428681.1","compounds":"sphinganine 1-phosphate => hexadecanal + phosphoethanolamine"}
{"X":21590,"RHEA_ID":18595,"compounds":"hexadecanal + phosphoethanolamine => sphinganine 1-phosphate"}
{"X":21591,"RHEA_ID":29234,"compounds":"cyanate(in) + H(+)(in) <=> cyanate(out) + H(+)(out)"}
{"X":21592,"RHEA_ID":18597,"DIRECTION":"UN","MASTER_ID":18597,"ec":"1.18.1.4","compounds":"H(+) + NAD(+) + 2 reduced [rubredoxin] = NADH + 2 oxidized [rubredoxin]"}
{"X":21593,"RHEA_ID":18597,"DIRECTION":"UN","MASTER_ID":18597,"ec":"1.18.1.1","compounds":"H(+) + NAD(+) + 2 reduced [rubredoxin] = NADH + 2 oxidized [rubredoxin]"}
{"X":21594,"RHEA_ID":18598,"compounds":"H(+) + NAD(+) + 2 reduced [rubredoxin] => NADH + 2 oxidized [rubredoxin]"}
{"X":21595,"RHEA_ID":18599,"compounds":"NADH + 2 oxidized [rubredoxin] => H(+) + NAD(+) + 2 reduced [rubredoxin]"}
{"X":21596,"RHEA_ID":18601,"DIRECTION":"UN","MASTER_ID":18601,"ec":"4.1.1.69","compounds":"3,4-dihydroxyphthalate + H(+) = 3,4-dihydroxybenzoate + CO2"}
{"X":21597,"RHEA_ID":18602,"DIRECTION":"LR","MASTER_ID":18601,"metacyc":"34-DIHYDROXYPHTHALATE-DECARBOXYLASE-RXN","compounds":"3,4-dihydroxyphthalate + H(+) => 3,4-dihydroxybenzoate + CO2"}
{"X":21598,"RHEA_ID":18603,"compounds":"3,4-dihydroxybenzoate + CO2 => 3,4-dihydroxyphthalate + H(+)"}
{"X":21599,"RHEA_ID":29244,"compounds":"H(+) + menaquinone-8 + NADH => menaquinol-8 + NAD(+)"}
{"X":21600,"RHEA_ID":18605,"DIRECTION":"UN","MASTER_ID":18605,"ec":"2.7.1.65","compounds":"1-amino-1-deoxy-scyllo-inositol + ATP = 1-amino-1-deoxy-scyllo-inositol 4-phosphate + ADP + H(+)"}
{"X":21601,"RHEA_ID":18606,"DIRECTION":"LR","MASTER_ID":18605,"metacyc":"SCYLLO-INOSAMINE-KINASE-RXN","compounds":"1-amino-1-deoxy-scyllo-inositol + ATP => 1-amino-1-deoxy-scyllo-inositol 4-phosphate + ADP + H(+)"}
{"X":21602,"RHEA_ID":18607,"compounds":"1-amino-1-deoxy-scyllo-inositol 4-phosphate + ADP + H(+) => 1-amino-1-deoxy-scyllo-inositol + ATP"}
{"X":21603,"RHEA_ID":29248,"DIRECTION":"LR","MASTER_ID":29247,"ecocyc":"TRANS-RXN-130","compounds":"3 H(+)(out) + 2 Na(+)(in) => 3 H(+)(in) + 2 Na(+)(out)"}
{"X":21604,"RHEA_ID":18609,"DIRECTION":"UN","MASTER_ID":18609,"ec":"2.1.3.9","compounds":"carbamoyl phosphate + N(2)-acetyl-L-ornithine = H(+) + N(2)-acetyl-L-citrulline + phosphate"}
{"X":21605,"RHEA_ID":18610,"compounds":"carbamoyl phosphate + N(2)-acetyl-L-ornithine => H(+) + N(2)-acetyl-L-citrulline + phosphate"}
{"X":21606,"RHEA_ID":18611,"compounds":"H(+) + N(2)-acetyl-L-citrulline + phosphate => carbamoyl phosphate + N(2)-acetyl-L-ornithine"}
{"X":21607,"RHEA_ID":29252,"DIRECTION":"LR","MASTER_ID":29251,"reactome":"R-HSA-2889070.1","compounds":"2 H(+)(out) + Na(+)(in) => 2 H(+)(in) + Na(+)(out)"}
{"X":21608,"RHEA_ID":18613,"DIRECTION":"UN","MASTER_ID":18613,"ec":"1.14.99.15","compounds":"4-methoxybenzoate + AH2 + O2 = 4-hydroxybenzoate + A + formaldehyde + H2O"}
{"X":21609,"RHEA_ID":18614,"DIRECTION":"LR","MASTER_ID":18613,"metacyc":"RXN-15127","compounds":"4-methoxybenzoate + AH2 + O2 => 4-hydroxybenzoate + A + formaldehyde + H2O"}
{"X":21610,"RHEA_ID":18615,"compounds":"4-hydroxybenzoate + A + formaldehyde + H2O => 4-methoxybenzoate + AH2 + O2"}
{"X":21611,"RHEA_ID":29256,"DIRECTION":"LR","MASTER_ID":29255,"ecocyc":"TRANS-RXN-128","reactome":"R-HSA-8949703.1","compounds":"Ca(2+)(in) + Na(+)(out) => Ca(2+)(out) + Na(+)(in)"}
{"X":21612,"RHEA_ID":18617,"DIRECTION":"UN","MASTER_ID":18617,"ec":"4.1.1.49","compounds":"ATP + oxaloacetate = ADP + CO2 + phosphoenolpyruvate"}
{"X":21613,"RHEA_ID":18618,"DIRECTION":"LR","MASTER_ID":18617,"ecocyc":"PEPCARBOXYKIN-RXN","macie":"M0051","metacyc":"PEPCARBOXYKIN-RXN","compounds":"ATP + oxaloacetate => ADP + CO2 + phosphoenolpyruvate"}
{"X":21614,"RHEA_ID":18619,"compounds":"ADP + CO2 + phosphoenolpyruvate => ATP + oxaloacetate"}
{"X":21615,"RHEA_ID":29260,"DIRECTION":"LR","MASTER_ID":29259,"ecocyc":"TRANS-RXN-127","compounds":"(2R,3R)-tartrate(out) + succinate(in) => (2R,3R)-tartrate(in) + succinate(out)"}
{"X":21616,"RHEA_ID":18621,"DIRECTION":"UN","MASTER_ID":18621,"ec":"1.14.11.9","compounds":"2-oxoglutarate + a (2S)-flavan-4-one + O2 = a (2R,3R)-dihydroflavonol + CO2 + succinate"}
{"X":21617,"RHEA_ID":18622,"DIRECTION":"LR","MASTER_ID":18621,"metacyc":"1.14.11.9-RXN","compounds":"2-oxoglutarate + a (2S)-flavan-4-one + O2 => a (2R,3R)-dihydroflavonol + CO2 + succinate"}
{"X":21618,"RHEA_ID":18623,"compounds":"a (2R,3R)-dihydroflavonol + CO2 + succinate => 2-oxoglutarate + a (2S)-flavan-4-one + O2"}
{"X":21619,"RHEA_ID":29264,"DIRECTION":"LR","MASTER_ID":29263,"reactome":"R-HSA-352059.1","compounds":"L-leucine(in) + Na(+)(in) => L-leucine(out) + Na(+)(out)"}
{"X":21620,"RHEA_ID":18625,"DIRECTION":"UN","MASTER_ID":18625,"ec":"1.1.1.120","compounds":"D-galactose + NADP(+) = D-galactono-1,5-lactone + H(+) + NADPH"}
{"X":21621,"RHEA_ID":18625,"DIRECTION":"UN","MASTER_ID":18625,"ec":"1.1.1.359","compounds":"D-galactose + NADP(+) = D-galactono-1,5-lactone + H(+) + NADPH"}
{"X":21622,"RHEA_ID":18625,"DIRECTION":"UN","MASTER_ID":18625,"ec":"1.1.1.360","compounds":"D-galactose + NADP(+) = D-galactono-1,5-lactone + H(+) + NADPH"}
{"X":21623,"RHEA_ID":18626,"compounds":"D-galactose + NADP(+) => D-galactono-1,5-lactone + H(+) + NADPH"}
{"X":21624,"RHEA_ID":18627,"compounds":"D-galactono-1,5-lactone + H(+) + NADPH => D-galactose + NADP(+)"}
{"X":21625,"RHEA_ID":18629,"DIRECTION":"UN","MASTER_ID":18629,"ec":"2.7.1.23","compounds":"ATP + NAD(+) = ADP + H(+) + NADP(+)"}
{"X":21626,"RHEA_ID":18630,"DIRECTION":"LR","MASTER_ID":18629,"ecocyc":"NAD-KIN-RXN","metacyc":"NAD-KIN-RXN","reactome":"R-HSA-8955030.1","compounds":"ATP + NAD(+) => ADP + H(+) + NADP(+)"}
{"X":21627,"RHEA_ID":18630,"DIRECTION":"LR","MASTER_ID":18629,"ecocyc":"NAD-KIN-RXN","metacyc":"NAD-KIN-RXN","reactome":"R-HSA-197198.2","compounds":"ATP + NAD(+) => ADP + H(+) + NADP(+)"}
{"X":21628,"RHEA_ID":18631,"compounds":"ADP + H(+) + NADP(+) => ATP + NAD(+)"}
{"X":21629,"RHEA_ID":29273,"compounds":"a menaquinone + H2O + trimethylamine => a menaquinol + H(+) + trimethylamine N-oxide"}
{"X":21630,"RHEA_ID":18633,"DIRECTION":"UN","MASTER_ID":18633,"ec":"6.3.5.5","compounds":"2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate"}
{"X":21631,"RHEA_ID":18634,"DIRECTION":"LR","MASTER_ID":18633,"ecocyc":"CARBPSYN-RXN","metacyc":"CARBPSYN-RXN","reactome":"R-HSA-73577.2","compounds":"2 ATP + H2O + hydrogencarbonate + L-glutamine => 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate"}
{"X":21632,"RHEA_ID":18635,"compounds":"2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate => 2 ATP + H2O + hydrogencarbonate + L-glutamine"}
{"X":21633,"RHEA_ID":29277,"DIRECTION":"RL","MASTER_ID":29275,"ecocyc":"TRANS-RXN-126","compounds":"L-isoleucine(out) + Na(+)(out) => L-isoleucine(in) + Na(+)(in)"}
{"X":21634,"RHEA_ID":18637,"DIRECTION":"UN","MASTER_ID":18637,"ec":"1.12.1.5","compounds":"H2 + NADP(+) = H(+) + NADPH"}
{"X":21635,"RHEA_ID":18637,"DIRECTION":"UN","MASTER_ID":18637,"ec":"1.12.1.3","compounds":"H2 + NADP(+) = H(+) + NADPH"}
{"X":21636,"RHEA_ID":18638,"compounds":"H2 + NADP(+) => H(+) + NADPH"}
{"X":21637,"RHEA_ID":18639,"compounds":"H(+) + NADPH => H2 + NADP(+)"}
{"X":21638,"RHEA_ID":18641,"DIRECTION":"UN","MASTER_ID":18641,"ec":"1.12.5.1","compounds":"a menaquinone + H2 = a menaquinol"}
{"X":21639,"RHEA_ID":18642,"compounds":"a menaquinone + H2 => a menaquinol"}
{"X":21640,"RHEA_ID":18643,"compounds":"a menaquinol => a menaquinone + H2"}
{"X":21641,"RHEA_ID":18645,"DIRECTION":"UN","MASTER_ID":18645,"ec":"2.5.1.44","compounds":"2 putrescine = NH4(+) + sym-homospermidine"}
{"X":21642,"RHEA_ID":18646,"compounds":"2 putrescine => NH4(+) + sym-homospermidine"}
{"X":21643,"RHEA_ID":18647,"compounds":"NH4(+) + sym-homospermidine => 2 putrescine"}
{"X":21644,"RHEA_ID":18649,"DIRECTION":"UN","MASTER_ID":18649,"ec":"4.2.1.140","compounds":"D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H2O"}
{"X":21645,"RHEA_ID":18649,"DIRECTION":"UN","MASTER_ID":18649,"ec":"4.2.1.6","compounds":"D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H2O"}
{"X":21646,"RHEA_ID":18650,"DIRECTION":"LR","MASTER_ID":18649,"ecocyc":"GALACTONDEHYDRAT-RXN","metacyc":"GALACTONDEHYDRAT-RXN","compounds":"D-galactonate => 2-dehydro-3-deoxy-D-galactonate + H2O"}
{"X":21647,"RHEA_ID":18651,"compounds":"2-dehydro-3-deoxy-D-galactonate + H2O => D-galactonate"}
{"X":21648,"RHEA_ID":39174,"compounds":"3-oxoeicosanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxyeicosanoyl-CoA + NADP(+)"}
{"X":21649,"RHEA_ID":18653,"DIRECTION":"UN","MASTER_ID":18653,"ec":"3.5.2.1","compounds":"barbiturate + H2O = 3-oxo-3-ureidopropanoate"}
{"X":21650,"RHEA_ID":18654,"DIRECTION":"LR","MASTER_ID":18653,"metacyc":"BARBITURASE-RXN","compounds":"barbiturate + H2O => 3-oxo-3-ureidopropanoate"}
{"X":21651,"RHEA_ID":18655,"compounds":"3-oxo-3-ureidopropanoate => barbiturate + H2O"}
{"X":21652,"RHEA_ID":29298,"compounds":"aldehydo-D-galacturonate(out) + H(+)(out) <=> aldehydo-D-galacturonate(in) + H(+)(in)"}
{"X":21653,"RHEA_ID":18657,"DIRECTION":"UN","MASTER_ID":18657,"ec":"1.1.1.81","compounds":"(R)-glycerate + NADP(+) = 3-hydroxypyruvate + H(+) + NADPH"}
{"X":21654,"RHEA_ID":18658,"compounds":"(R)-glycerate + NADP(+) => 3-hydroxypyruvate + H(+) + NADPH"}
{"X":21655,"RHEA_ID":18659,"DIRECTION":"RL","MASTER_ID":18657,"ecocyc":"RXN0-300","metacyc":"RXN0-300","compounds":"3-hydroxypyruvate + H(+) + NADPH => (R)-glycerate + NADP(+)"}
{"X":21656,"RHEA_ID":29306,"compounds":"2 H(+)(in) + succinate(in) <=> 2 H(+)(out) + succinate(out)"}
{"X":21657,"RHEA_ID":18661,"DIRECTION":"UN","MASTER_ID":18661,"ec":"1.5.1.24","compounds":"H2O + N(5)-[1(S)-1-carboxyethyl]-L-ornithine + NADP(+) = H(+) + L-ornithine + NADPH + pyruvate"}
{"X":21658,"RHEA_ID":18662,"compounds":"H2O + N(5)-[1(S)-1-carboxyethyl]-L-ornithine + NADP(+) => H(+) + L-ornithine + NADPH + pyruvate"}
{"X":21659,"RHEA_ID":18663,"compounds":"H(+) + L-ornithine + NADPH + pyruvate => H2O + N(5)-[1(S)-1-carboxyethyl]-L-ornithine + NADP(+)"}
{"X":21660,"RHEA_ID":39186,"compounds":"3-oxodocosanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxydocosanoyl-CoA + NADP(+)"}
{"X":21661,"RHEA_ID":18665,"DIRECTION":"UN","MASTER_ID":18665,"ec":"2.7.4.17","metacyc":"2.7.4.17-RXN","compounds":"(2R)-3-phospho-glyceroyl phosphate + [phosphate](n) = (2R)-3-phosphoglycerate + [phosphate](n+1)"}
{"X":21662,"RHEA_ID":18666,"compounds":"(2R)-3-phospho-glyceroyl phosphate + [phosphate](n) => (2R)-3-phosphoglycerate + [phosphate](n+1)"}
{"X":21663,"RHEA_ID":18667,"compounds":"(2R)-3-phosphoglycerate + [phosphate](n+1) => (2R)-3-phospho-glyceroyl phosphate + [phosphate](n)"}
{"X":21664,"RHEA_ID":29314,"compounds":"FMNH2 + O2 + sulfoacetate <=> FMN + glyoxylate + 2 H(+) + H2O + sulfite"}
{"X":21665,"RHEA_ID":18669,"DIRECTION":"UN","MASTER_ID":18669,"ec":"3.2.2.7","compounds":"adenosine + H2O = adenine + D-ribose"}
{"X":21666,"RHEA_ID":18670,"DIRECTION":"LR","MASTER_ID":18669,"ecocyc":"ADENOSINE-NUCLEOSIDASE-RXN","metacyc":"ADENOSINE-NUCLEOSIDASE-RXN","compounds":"adenosine + H2O => adenine + D-ribose"}
{"X":21667,"RHEA_ID":18671,"compounds":"adenine + D-ribose => adenosine + H2O"}
{"X":21668,"RHEA_ID":39194,"compounds":"(2E)-docosenoyl-CoA + H(+) + NADPH <=> docosanoyl-CoA + NADP(+)"}
{"X":21669,"RHEA_ID":18673,"DIRECTION":"UN","MASTER_ID":18673,"ec":"2.7.11.30","compounds":"[receptor-protein]-L-serine + ATP = [receptor-protein]-O-phospho-L-serine + ADP + H(+)"}
{"X":21670,"RHEA_ID":18674,"compounds":"[receptor-protein]-L-serine + ATP => [receptor-protein]-O-phospho-L-serine + ADP + H(+)"}
{"X":21671,"RHEA_ID":18675,"compounds":"[receptor-protein]-O-phospho-L-serine + ADP + H(+) => [receptor-protein]-L-serine + ATP"}
{"X":21672,"RHEA_ID":18676,"DIRECTION":"BI","MASTER_ID":18673,"metacyc":"2.7.11.30-RXN","compounds":"[receptor-protein]-L-serine + ATP <=> [receptor-protein]-O-phospho-L-serine + ADP + H(+)"}
{"X":21673,"RHEA_ID":18677,"DIRECTION":"UN","MASTER_ID":18677,"ec":"1.10.2.1","metacyc":"1.10.2.1-RXN","compounds":"[Fe(III)-cytochrome b5] + L-ascorbate = [Fe(II)-cytochrome b5] + H(+) + monodehydro-L-ascorbate radical"}
{"X":21674,"RHEA_ID":18678,"compounds":"[Fe(III)-cytochrome b5] + L-ascorbate => [Fe(II)-cytochrome b5] + H(+) + monodehydro-L-ascorbate radical"}
{"X":21675,"RHEA_ID":18679,"compounds":"[Fe(II)-cytochrome b5] + H(+) + monodehydro-L-ascorbate radical => [Fe(III)-cytochrome b5] + L-ascorbate"}
{"X":21676,"RHEA_ID":18681,"DIRECTION":"UN","MASTER_ID":18681,"ec":"2.5.1.7","compounds":"phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine"}
{"X":21677,"RHEA_ID":18682,"DIRECTION":"LR","MASTER_ID":18681,"ecocyc":"UDPNACETYLGLUCOSAMENOLPYRTRANS-RXN","metacyc":"UDPNACETYLGLUCOSAMENOLPYRTRANS-RXN","compounds":"phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine => phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine"}
{"X":21678,"RHEA_ID":18683,"compounds":"phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine => phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":21679,"RHEA_ID":29330,"compounds":"(S)-malate(in) + succinate(out) <=> (S)-malate(out) + succinate(in)"}
{"X":21680,"RHEA_ID":18685,"DIRECTION":"UN","MASTER_ID":18685,"ec":"1.14.13.50","compounds":"H(+) + NADPH + O2 + pentachlorophenol = 2,3,5,6-tetrachloro-1,4-benzoquinone + chloride + H2O + NADP(+)"}
{"X":21681,"RHEA_ID":18686,"DIRECTION":"LR","MASTER_ID":18685,"metacyc":"PCP4MONO-RXN","compounds":"H(+) + NADPH + O2 + pentachlorophenol => 2,3,5,6-tetrachloro-1,4-benzoquinone + chloride + H2O + NADP(+)"}
{"X":21682,"RHEA_ID":18687,"compounds":"2,3,5,6-tetrachloro-1,4-benzoquinone + chloride + H2O + NADP(+) => H(+) + NADPH + O2 + pentachlorophenol"}
{"X":21683,"RHEA_ID":29334,"compounds":"fumarate(in) + 2 H(+)(in) <=> fumarate(out) + 2 H(+)(out)"}
{"X":21684,"RHEA_ID":18689,"DIRECTION":"UN","MASTER_ID":18689,"ec":"3.1.1.32","compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)"}
{"X":21685,"RHEA_ID":18690,"DIRECTION":"LR","MASTER_ID":18689,"ecocyc":"PHOSPHOLIPASE-A1-RXN","metacyc":"PHOSPHOLIPASE-A1-RXN","compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O => a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)"}
{"X":21686,"RHEA_ID":18691,"compounds":"a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O"}
{"X":21687,"RHEA_ID":18693,"DIRECTION":"UN","MASTER_ID":18693,"ec":"3.5.1.11","metacyc":"PENICILLIN-AMIDASE-RXN","compounds":"H2O + penicillin = 6-aminopenicillanate + a carboxylate"}
{"X":21688,"RHEA_ID":18694,"compounds":"H2O + penicillin => 6-aminopenicillanate + a carboxylate"}
{"X":21689,"RHEA_ID":18695,"compounds":"6-aminopenicillanate + a carboxylate => H2O + penicillin"}
{"X":21690,"RHEA_ID":18697,"DIRECTION":"UN","MASTER_ID":18697,"ec":"4.1.1.80","compounds":"3-(4-hydroxyphenyl)pyruvate + H(+) = (4-hydroxyphenyl)acetaldehyde + CO2"}
{"X":21691,"RHEA_ID":18698,"DIRECTION":"LR","MASTER_ID":18697,"metacyc":"4.1.1.80-RXN","compounds":"3-(4-hydroxyphenyl)pyruvate + H(+) => (4-hydroxyphenyl)acetaldehyde + CO2"}
{"X":21692,"RHEA_ID":18699,"compounds":"(4-hydroxyphenyl)acetaldehyde + CO2 => 3-(4-hydroxyphenyl)pyruvate + H(+)"}
{"X":21693,"RHEA_ID":29346,"compounds":"L-aspartate(in) + succinate(out) <=> L-aspartate(out) + succinate(in)"}
{"X":21694,"RHEA_ID":18701,"DIRECTION":"UN","MASTER_ID":18701,"ec":"1.20.9.1","compounds":"arsenite + H2O + 2 oxidized [azurin] = arsenate + 3 H(+) + 2 reduced [azurin]"}
{"X":21695,"RHEA_ID":18702,"DIRECTION":"LR","MASTER_ID":18701,"metacyc":"1.20.98.1-RXN","compounds":"arsenite + H2O + 2 oxidized [azurin] => arsenate + 3 H(+) + 2 reduced [azurin]"}
{"X":21696,"RHEA_ID":18703,"compounds":"arsenate + 3 H(+) + 2 reduced [azurin] => arsenite + H2O + 2 oxidized [azurin]"}
{"X":21697,"RHEA_ID":18705,"compounds":"a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = a beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP"}
{"X":21698,"RHEA_ID":18706,"compounds":"a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine => a beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP"}
{"X":21699,"RHEA_ID":18707,"compounds":"a beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP => a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":21700,"RHEA_ID":29352,"DIRECTION":"LR","MASTER_ID":29351,"reactome":"R-HSA-442345.1","compounds":"Zn(2+)(in) => Zn(2+)(out)"}
{"X":21701,"RHEA_ID":18709,"DIRECTION":"UN","MASTER_ID":18709,"ec":"1.4.99.2","compounds":"A + H2O + taurine = AH2 + NH4(+) + sulfoacetaldehyde"}
{"X":21702,"RHEA_ID":18710,"DIRECTION":"LR","MASTER_ID":18709,"metacyc":"TAURINE-DEHYDROGENASE-RXN","compounds":"A + H2O + taurine => AH2 + NH4(+) + sulfoacetaldehyde"}
{"X":21703,"RHEA_ID":18711,"compounds":"AH2 + NH4(+) + sulfoacetaldehyde => A + H2O + taurine"}
{"X":21704,"RHEA_ID":29352,"DIRECTION":"LR","MASTER_ID":29351,"reactome":"R-HSA-442387.1","compounds":"Zn(2+)(in) => Zn(2+)(out)"}
{"X":21705,"RHEA_ID":18713,"compounds":"2-oxoglutarate + UDP-N-acetylbacillosamine = L-glutamate + UDP-2-acetamido-2,6-dideoxy-beta-D-gluco-hex-4-ulose"}
{"X":21706,"RHEA_ID":18714,"compounds":"2-oxoglutarate + UDP-N-acetylbacillosamine => L-glutamate + UDP-2-acetamido-2,6-dideoxy-beta-D-gluco-hex-4-ulose"}
{"X":21707,"RHEA_ID":18715,"compounds":"L-glutamate + UDP-2-acetamido-2,6-dideoxy-beta-D-gluco-hex-4-ulose => 2-oxoglutarate + UDP-N-acetylbacillosamine"}
{"X":21708,"RHEA_ID":18716,"compounds":"2-oxoglutarate + UDP-N-acetylbacillosamine <=> L-glutamate + UDP-2-acetamido-2,6-dideoxy-beta-D-gluco-hex-4-ulose"}
{"X":21709,"RHEA_ID":18717,"DIRECTION":"UN","MASTER_ID":18717,"ec":"2.1.1.84","compounds":"3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine = 3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine"}
{"X":21710,"RHEA_ID":18718,"DIRECTION":"LR","MASTER_ID":18717,"metacyc":"2.1.1.84-RXN","compounds":"3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine => 3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine"}
{"X":21711,"RHEA_ID":18719,"compounds":"3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine => 3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine"}
{"X":21712,"RHEA_ID":29355,"compounds":"dUMP + H2O = 2'-deoxyuridine + phosphate"}
{"X":21713,"RHEA_ID":18721,"DIRECTION":"UN","MASTER_ID":18721,"ec":"4.2.3.186","compounds":"ent-8alpha-hydroxylabd-13-en-15-yl diphosphate = diphosphate + ent-13-epi-manoyl oxide"}
{"X":21714,"RHEA_ID":18722,"DIRECTION":"LR","MASTER_ID":18721,"metacyc":"RXN-18892","compounds":"ent-8alpha-hydroxylabd-13-en-15-yl diphosphate => diphosphate + ent-13-epi-manoyl oxide"}
{"X":21715,"RHEA_ID":18723,"compounds":"diphosphate + ent-13-epi-manoyl oxide => ent-8alpha-hydroxylabd-13-en-15-yl diphosphate"}
{"X":21716,"RHEA_ID":29359,"compounds":"H2O + UMP = phosphate + uridine"}
{"X":21717,"RHEA_ID":18725,"DIRECTION":"UN","MASTER_ID":18725,"ec":"4.1.2.41","compounds":"3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA = acetyl-CoA + vanillin"}
{"X":21718,"RHEA_ID":18726,"DIRECTION":"LR","MASTER_ID":18725,"metacyc":"4.1.2.41-RXN","compounds":"3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA => acetyl-CoA + vanillin"}
{"X":21719,"RHEA_ID":18727,"compounds":"acetyl-CoA + vanillin => 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA"}
{"X":21720,"RHEA_ID":29363,"compounds":"dCMP + H2O = 2'-deoxycytidine + phosphate"}
{"X":21721,"RHEA_ID":18737,"DIRECTION":"UN","MASTER_ID":18737,"ec":"2.7.9.3","compounds":"ATP + H2O + hydrogenselenide = AMP + 2 H(+) + phosphate + selenophosphate"}
{"X":21722,"RHEA_ID":18738,"DIRECTION":"LR","MASTER_ID":18737,"ecocyc":"2.7.9.3-RXN","metacyc":"2.7.9.3-RXN","reactome":"R-HSA-8959510.1","compounds":"ATP + H2O + hydrogenselenide => AMP + 2 H(+) + phosphate + selenophosphate"}
{"X":21723,"RHEA_ID":18739,"compounds":"AMP + 2 H(+) + phosphate + selenophosphate => ATP + H2O + hydrogenselenide"}
{"X":21724,"RHEA_ID":39254,"compounds":"(2E,11Z)-eicosadienoyl-CoA + H(+) + NADPH <=> (11Z)-eicosenoyl-CoA + NADP(+)"}
{"X":21725,"RHEA_ID":18741,"DIRECTION":"UN","MASTER_ID":18741,"ec":"2.3.1.166","compounds":"10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA = 10-deacetylbaccatin III + CoA"}
{"X":21726,"RHEA_ID":18742,"DIRECTION":"LR","MASTER_ID":18741,"metacyc":"2.3.1.166-RXN","compounds":"10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA => 10-deacetylbaccatin III + CoA"}
{"X":21727,"RHEA_ID":18743,"compounds":"10-deacetylbaccatin III + CoA => 10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA"}
{"X":21728,"RHEA_ID":39258,"compounds":"(13Z)-3-oxodocosenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(13Z)-docosenoyl-CoA + NADP(+)"}
{"X":21729,"RHEA_ID":18745,"DIRECTION":"UN","MASTER_ID":18745,"ec":"1.17.3.4","compounds":"2 juglone + O2 = 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+)"}
{"X":21730,"RHEA_ID":18746,"DIRECTION":"LR","MASTER_ID":18745,"metacyc":"JUGLONE-3-MONOOXYGENASE-RXN","compounds":"2 juglone + O2 => 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+)"}
{"X":21731,"RHEA_ID":18747,"compounds":"2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+) => 2 juglone + O2"}
{"X":21732,"RHEA_ID":39262,"compounds":"(3R)-hydroxy-(13Z)-docosenoyl-CoA <=> (2E,13Z)-docosadienoyl-CoA + H2O"}
{"X":21733,"RHEA_ID":18749,"DIRECTION":"UN","MASTER_ID":18749,"ec":"1.8.1.8","compounds":"[protein]-dithiol + NAD(+) = [protein]-disulfide + H(+) + NADH"}
{"X":21734,"RHEA_ID":18750,"compounds":"[protein]-dithiol + NAD(+) => [protein]-disulfide + H(+) + NADH"}
{"X":21735,"RHEA_ID":18751,"compounds":"[protein]-disulfide + H(+) + NADH => [protein]-dithiol + NAD(+)"}
{"X":21736,"RHEA_ID":18753,"DIRECTION":"UN","MASTER_ID":18753,"ec":"1.8.1.8","compounds":"[protein]-dithiol + NADP(+) = [protein]-disulfide + H(+) + NADPH"}
{"X":21737,"RHEA_ID":18754,"compounds":"[protein]-dithiol + NADP(+) => [protein]-disulfide + H(+) + NADPH"}
{"X":21738,"RHEA_ID":18755,"compounds":"[protein]-disulfide + H(+) + NADPH => [protein]-dithiol + NADP(+)"}
{"X":21739,"RHEA_ID":18757,"DIRECTION":"UN","MASTER_ID":18757,"ec":"1.14.11.70","compounds":"2-oxoglutarate + 7-deoxycylindrospermopsin + O2 = CO2 + cylindrospermopsin + succinate"}
{"X":21740,"RHEA_ID":18758,"DIRECTION":"LR","MASTER_ID":18757,"metacyc":"RXN-20448","compounds":"2-oxoglutarate + 7-deoxycylindrospermopsin + O2 => CO2 + cylindrospermopsin + succinate"}
{"X":21741,"RHEA_ID":18759,"compounds":"CO2 + cylindrospermopsin + succinate => 2-oxoglutarate + 7-deoxycylindrospermopsin + O2"}
{"X":21742,"RHEA_ID":29385,"compounds":"2'-deoxyinosine + phosphate => dIMP + H2O"}
{"X":21743,"RHEA_ID":18761,"compounds":"a 1,2-diacyl-sn-glycerol + H2O = a fatty acid + a monoacylglycerol + H(+)"}
{"X":21744,"RHEA_ID":18762,"DIRECTION":"LR","MASTER_ID":18761,"metacyc":"RXN-7950","compounds":"a 1,2-diacyl-sn-glycerol + H2O => a fatty acid + a monoacylglycerol + H(+)"}
{"X":21745,"RHEA_ID":18763,"compounds":"a fatty acid + a monoacylglycerol + H(+) => a 1,2-diacyl-sn-glycerol + H2O"}
{"X":21746,"RHEA_ID":18765,"DIRECTION":"UN","MASTER_ID":18765,"ec":"2.7.8.27","compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = a 1,2-diacyl-sn-glycerol + sphingomyelin"}
{"X":21747,"RHEA_ID":18766,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine => a 1,2-diacyl-sn-glycerol + sphingomyelin"}
{"X":21748,"RHEA_ID":18767,"compounds":"a 1,2-diacyl-sn-glycerol + sphingomyelin => a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine"}
{"X":21749,"RHEA_ID":18769,"DIRECTION":"UN","MASTER_ID":18769,"ec":"5.3.2.5","compounds":"5-methylsulfanyl-2,3-dioxopentyl phosphate = 2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate"}
{"X":21750,"RHEA_ID":18770,"DIRECTION":"LR","MASTER_ID":18769,"metacyc":"R82-RXN","compounds":"5-methylsulfanyl-2,3-dioxopentyl phosphate => 2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate"}
{"X":21751,"RHEA_ID":18771,"compounds":"2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate => 5-methylsulfanyl-2,3-dioxopentyl phosphate"}
{"X":21752,"RHEA_ID":29395,"DIRECTION":"UN","MASTER_ID":29395,"ec":"3.6.1.8","compounds":"H2O + UTP = diphosphate + H(+) + UMP"}
{"X":21753,"RHEA_ID":18773,"DIRECTION":"UN","MASTER_ID":18773,"ec":"2.1.1.247","compounds":"[methyl-Co(III) methylamine-specific corrinoid protein] + coenzyme M = [Co(I) methylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M"}
{"X":21754,"RHEA_ID":18774,"DIRECTION":"LR","MASTER_ID":18773,"metacyc":"RXN-8099","compounds":"[methyl-Co(III) methylamine-specific corrinoid protein] + coenzyme M => [Co(I) methylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M"}
{"X":21755,"RHEA_ID":18775,"compounds":"[Co(I) methylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M => [methyl-Co(III) methylamine-specific corrinoid protein] + coenzyme M"}
{"X":21756,"RHEA_ID":18776,"compounds":"[methyl-Co(III) methylamine-specific corrinoid protein] + coenzyme M <=> [Co(I) methylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M"}
{"X":21757,"RHEA_ID":18777,"DIRECTION":"UN","MASTER_ID":18777,"ec":"4.99.1.2","compounds":"an alkylmercury + H(+) = an alkane + Hg(2+)"}
{"X":21758,"RHEA_ID":18778,"compounds":"an alkylmercury + H(+) => an alkane + Hg(2+)"}
{"X":21759,"RHEA_ID":18779,"compounds":"an alkane + Hg(2+) => an alkylmercury + H(+)"}
{"X":21760,"RHEA_ID":18781,"DIRECTION":"UN","MASTER_ID":18781,"ec":"4.1.1.9","compounds":"H(+) + malonyl-CoA = acetyl-CoA + CO2"}
{"X":21761,"RHEA_ID":18782,"DIRECTION":"LR","MASTER_ID":18781,"metacyc":"MALONYL-COA-DECARBOXYLASE-RXN","reactome":"R-HSA-977317.2","compounds":"H(+) + malonyl-CoA => acetyl-CoA + CO2"}
{"X":21762,"RHEA_ID":18783,"compounds":"acetyl-CoA + CO2 => H(+) + malonyl-CoA"}
{"X":21763,"RHEA_ID":29405,"compounds":"3-demethylubiquinol-8 + A + H2O => 6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + AH2 + O2"}
{"X":21764,"RHEA_ID":18789,"DIRECTION":"UN","MASTER_ID":18789,"ec":"5.1.3.42","compounds":"D-glucosamine 6-phosphate = D-galactosamine 6-phosphate"}
{"X":21765,"RHEA_ID":18790,"compounds":"D-glucosamine 6-phosphate => D-galactosamine 6-phosphate"}
{"X":21766,"RHEA_ID":18791,"compounds":"D-galactosamine 6-phosphate => D-glucosamine 6-phosphate"}
{"X":21767,"RHEA_ID":18792,"DIRECTION":"BI","MASTER_ID":18789,"metacyc":"RXN-19878","compounds":"D-glucosamine 6-phosphate <=> D-galactosamine 6-phosphate"}
{"X":21768,"RHEA_ID":18793,"DIRECTION":"UN","MASTER_ID":18793,"ec":"5.4.2.7","compounds":"alpha-D-ribose 1-phosphate = D-ribose 5-phosphate"}
{"X":21769,"RHEA_ID":18794,"compounds":"alpha-D-ribose 1-phosphate => D-ribose 5-phosphate"}
{"X":21770,"RHEA_ID":18795,"compounds":"D-ribose 5-phosphate => alpha-D-ribose 1-phosphate"}
{"X":21771,"RHEA_ID":29413,"DIRECTION":"RL","MASTER_ID":29411,"ecocyc":"TRANS-RXN-105","compounds":"glycolate(out) + H(+)(out) => glycolate(in) + H(+)(in)"}
{"X":21772,"RHEA_ID":18797,"compounds":"a 3'-hydroxy,5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase] = a 3',5'-dihydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":21773,"RHEA_ID":18798,"DIRECTION":"LR","MASTER_ID":18797,"metacyc":"RXN-8671","compounds":"a 3'-hydroxy,5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase] => a 3',5'-dihydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":21774,"RHEA_ID":18799,"compounds":"a 3',5'-dihydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 3'-hydroxy,5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":21775,"RHEA_ID":29417,"DIRECTION":"RL","MASTER_ID":29415,"ecocyc":"TRANS-RXN-104","reactome":"R-HSA-373875.3","compounds":"(S)-lactate(out) + H(+)(out) => (S)-lactate(in) + H(+)(in)"}
{"X":21776,"RHEA_ID":18801,"DIRECTION":"UN","MASTER_ID":18801,"ec":"2.5.1.20","compounds":"(cis-prenyl)n-diphosphate + isopentenyl diphosphate = (cis-prenyl)(n+1)-diphosphate + diphosphate"}
{"X":21777,"RHEA_ID":18802,"compounds":"(cis-prenyl)n-diphosphate + isopentenyl diphosphate => (cis-prenyl)(n+1)-diphosphate + diphosphate"}
{"X":21778,"RHEA_ID":18803,"compounds":"(cis-prenyl)(n+1)-diphosphate + diphosphate => (cis-prenyl)n-diphosphate + isopentenyl diphosphate"}
{"X":21779,"RHEA_ID":18805,"DIRECTION":"UN","MASTER_ID":18805,"ec":"1.8.4.15","compounds":"[DsbA protein]-disulfide + [protein]-dithiol = [DsbA protein]-dithiol + [protein]-disulfide"}
{"X":21780,"RHEA_ID":18806,"DIRECTION":"LR","MASTER_ID":18805,"ecocyc":"RXN0-7310","metacyc":"RXN0-7310","compounds":"[DsbA protein]-disulfide + [protein]-dithiol => [DsbA protein]-dithiol + [protein]-disulfide"}
{"X":21781,"RHEA_ID":18807,"compounds":"[DsbA protein]-dithiol + [protein]-disulfide => [DsbA protein]-disulfide + [protein]-dithiol"}
{"X":21782,"RHEA_ID":18808,"compounds":"[DsbA protein]-disulfide + [protein]-dithiol <=> [DsbA protein]-dithiol + [protein]-disulfide"}
{"X":21783,"RHEA_ID":18809,"DIRECTION":"UN","MASTER_ID":18809,"ec":"2.6.1.47","compounds":"L-alanine + oxomalonate = aminomalonate + pyruvate"}
{"X":21784,"RHEA_ID":18810,"compounds":"L-alanine + oxomalonate => aminomalonate + pyruvate"}
{"X":21785,"RHEA_ID":18811,"compounds":"aminomalonate + pyruvate => L-alanine + oxomalonate"}
{"X":21786,"RHEA_ID":29428,"DIRECTION":"LR","MASTER_ID":29427,"ecocyc":"TRANS-RXN-100","compounds":"(R)-carnitine(out) + 4-(trimethylamino)butanoate(in) => (R)-carnitine(in) + 4-(trimethylamino)butanoate(out)"}
{"X":21787,"RHEA_ID":18813,"DIRECTION":"UN","MASTER_ID":18813,"ec":"5.3.3.10","compounds":"(2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate = (3E,5R)-5-carboxy-2-oxohept-3-enedioate"}
{"X":21788,"RHEA_ID":18814,"DIRECTION":"LR","MASTER_ID":18813,"metacyc":"5.3.3.10-RXN","compounds":"(2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate => (3E,5R)-5-carboxy-2-oxohept-3-enedioate"}
{"X":21789,"RHEA_ID":18815,"compounds":"(3E,5R)-5-carboxy-2-oxohept-3-enedioate => (2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate"}
{"X":21790,"RHEA_ID":29432,"compounds":"ATP + phosphate => ADP + diphosphate"}
{"X":21791,"RHEA_ID":18817,"DIRECTION":"UN","MASTER_ID":18817,"ec":"2.8.3.3","metacyc":"MALONATE-COA-TRANSFERASE-RXN","compounds":"acetyl-CoA + malonate = acetate + malonyl-CoA"}
{"X":21792,"RHEA_ID":18818,"compounds":"acetyl-CoA + malonate => acetate + malonyl-CoA"}
{"X":21793,"RHEA_ID":18819,"compounds":"acetate + malonyl-CoA => acetyl-CoA + malonate"}
{"X":21794,"RHEA_ID":29436,"DIRECTION":"LR","MASTER_ID":29435,"ecocyc":"RXN0-8","metacyc":"RXN0-8","compounds":"enterobactin(in) + H(+)(out) => enterobactin(out) + H(+)(in)"}
{"X":21795,"RHEA_ID":18821,"DIRECTION":"UN","MASTER_ID":18821,"ec":"2.3.1.6","compounds":"acetyl-CoA + choline = acetylcholine + CoA"}
{"X":21796,"RHEA_ID":18822,"DIRECTION":"LR","MASTER_ID":18821,"reactome":"R-HSA-264622.2","compounds":"acetyl-CoA + choline => acetylcholine + CoA"}
{"X":21797,"RHEA_ID":18823,"compounds":"acetylcholine + CoA => acetyl-CoA + choline"}
{"X":21798,"RHEA_ID":29440,"DIRECTION":"LR","MASTER_ID":29439,"ecocyc":"RXN0-6","compounds":"Fe(2+)(in) + H(+)(out) => Fe(2+)(out) + H(+)(in)"}
{"X":21799,"RHEA_ID":18825,"DIRECTION":"UN","MASTER_ID":18825,"ec":"2.4.1.125","compounds":"[(1->6)-alpha-D-glucosyl](n) + sucrose = [(1->6)-alpha-D-glucosyl](n+1) + D-fructose"}
{"X":21800,"RHEA_ID":18825,"DIRECTION":"UN","MASTER_ID":18825,"ec":"2.4.1.5","compounds":"[(1->6)-alpha-D-glucosyl](n) + sucrose = [(1->6)-alpha-D-glucosyl](n+1) + D-fructose"}
{"X":21801,"RHEA_ID":18826,"compounds":"[(1->6)-alpha-D-glucosyl](n) + sucrose => [(1->6)-alpha-D-glucosyl](n+1) + D-fructose"}
{"X":21802,"RHEA_ID":18827,"compounds":"[(1->6)-alpha-D-glucosyl](n+1) + D-fructose => [(1->6)-alpha-D-glucosyl](n) + sucrose"}
{"X":21803,"RHEA_ID":29445,"DIRECTION":"RL","MASTER_ID":29443,"ecocyc":"RXN0-5202","compounds":"H(+)(out) + L-alanine(out) => H(+)(in) + L-alanine(in)"}
{"X":21804,"RHEA_ID":18829,"DIRECTION":"UN","MASTER_ID":18829,"ec":"1.1.1.290","compounds":"4-phospho-D-erythronate + NAD(+) = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + H(+) + NADH"}
{"X":21805,"RHEA_ID":18830,"DIRECTION":"LR","MASTER_ID":18829,"ecocyc":"ERYTHRON4PDEHYDROG-RXN","metacyc":"ERYTHRON4PDEHYDROG-RXN","compounds":"4-phospho-D-erythronate + NAD(+) => (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + H(+) + NADH"}
{"X":21806,"RHEA_ID":18831,"compounds":"(R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + H(+) + NADH => 4-phospho-D-erythronate + NAD(+)"}
{"X":21807,"RHEA_ID":29449,"DIRECTION":"RL","MASTER_ID":29447,"ecocyc":"RXN0-5111","reactome":"R-HSA-8953430.1","compounds":"glycolate(out) => glycolate(in)"}
{"X":21808,"RHEA_ID":18833,"DIRECTION":"UN","MASTER_ID":18833,"ec":"1.2.1.62","compounds":"4-formylbenzenesulfonate + H2O + NAD(+) = 4-sulfobenzoate + 2 H(+) + NADH"}
{"X":21809,"RHEA_ID":18834,"compounds":"4-formylbenzenesulfonate + H2O + NAD(+) => 4-sulfobenzoate + 2 H(+) + NADH"}
{"X":21810,"RHEA_ID":18835,"compounds":"4-sulfobenzoate + 2 H(+) + NADH => 4-formylbenzenesulfonate + H2O + NAD(+)"}
{"X":21811,"RHEA_ID":29453,"compounds":"H2 + phosphate => H2O + phosphonate"}
{"X":21812,"RHEA_ID":18837,"DIRECTION":"UN","MASTER_ID":18837,"ec":"2.3.1.163","metacyc":"2.3.1.163-RXN","compounds":"10-deacetyltaxuyunnanin C + acetyl-CoA = CoA + taxuyunnanin C"}
{"X":21813,"RHEA_ID":18838,"compounds":"10-deacetyltaxuyunnanin C + acetyl-CoA => CoA + taxuyunnanin C"}
{"X":21814,"RHEA_ID":18839,"compounds":"CoA + taxuyunnanin C => 10-deacetyltaxuyunnanin C + acetyl-CoA"}
{"X":21815,"RHEA_ID":29457,"DIRECTION":"RL","MASTER_ID":29455,"ecocyc":"RXN0-5130","compounds":"D-serine(out) => D-serine(in)"}
{"X":21816,"RHEA_ID":18841,"DIRECTION":"UN","MASTER_ID":18841,"ec":"1.1.1.60","compounds":"(R)-glycerate + NADP(+) = 2-hydroxy-3-oxopropanoate + H(+) + NADPH"}
{"X":21817,"RHEA_ID":18842,"compounds":"(R)-glycerate + NADP(+) => 2-hydroxy-3-oxopropanoate + H(+) + NADPH"}
{"X":21818,"RHEA_ID":18843,"DIRECTION":"RL","MASTER_ID":18841,"ecocyc":"TSA-REDUCT-RXN","metacyc":"TSA-REDUCT-RXN","compounds":"2-hydroxy-3-oxopropanoate + H(+) + NADPH => (R)-glycerate + NADP(+)"}
{"X":21819,"RHEA_ID":29461,"DIRECTION":"RL","MASTER_ID":29459,"ecocyc":"RXN0-5201","compounds":"beta-alanine(out) + H(+)(out) => beta-alanine(in) + H(+)(in)"}
{"X":21820,"RHEA_ID":18845,"DIRECTION":"UN","MASTER_ID":18845,"ec":"1.1.1.60","compounds":"(R)-glycerate + NAD(+) = 2-hydroxy-3-oxopropanoate + H(+) + NADH"}
{"X":21821,"RHEA_ID":18846,"compounds":"(R)-glycerate + NAD(+) => 2-hydroxy-3-oxopropanoate + H(+) + NADH"}
{"X":21822,"RHEA_ID":18847,"DIRECTION":"RL","MASTER_ID":18845,"ecocyc":"TSA-REDUCT-RXN","metacyc":"TSA-REDUCT-RXN","compounds":"2-hydroxy-3-oxopropanoate + H(+) + NADH => (R)-glycerate + NAD(+)"}
{"X":21823,"RHEA_ID":29464,"DIRECTION":"LR","MASTER_ID":29463,"reactome":"R-HSA-5678261.2","compounds":"K(+)(in) => K(+)(out)"}
{"X":21824,"RHEA_ID":18849,"DIRECTION":"UN","MASTER_ID":18849,"ec":"1.14.14.90","compounds":"a 2'-unsubstituted isoflavone + O2 + reduced [NADPH--hemoprotein reductase] = a 2'-hydroxyisoflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":21825,"RHEA_ID":18850,"DIRECTION":"LR","MASTER_ID":18849,"metacyc":"RXN-11846","compounds":"a 2'-unsubstituted isoflavone + O2 + reduced [NADPH--hemoprotein reductase] => a 2'-hydroxyisoflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":21826,"RHEA_ID":18851,"compounds":"a 2'-hydroxyisoflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 2'-unsubstituted isoflavone + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":21827,"RHEA_ID":29465,"DIRECTION":"RL","MASTER_ID":29463,"ecocyc":"TRANS-RXN-143","reactome":"R-HSA-5683209.1","compounds":"K(+)(out) => K(+)(in)"}
{"X":21828,"RHEA_ID":18853,"DIRECTION":"UN","MASTER_ID":18853,"ec":"1.1.1.93","compounds":"NAD(+) + tartrate = 2-hydroxy-3-oxosuccinate + H(+) + NADH"}
{"X":21829,"RHEA_ID":18854,"compounds":"NAD(+) + tartrate => 2-hydroxy-3-oxosuccinate + H(+) + NADH"}
{"X":21830,"RHEA_ID":18855,"compounds":"2-hydroxy-3-oxosuccinate + H(+) + NADH => NAD(+) + tartrate"}
{"X":21831,"RHEA_ID":18856,"compounds":"NAD(+) + tartrate <=> 2-hydroxy-3-oxosuccinate + H(+) + NADH"}
{"X":21832,"RHEA_ID":18857,"DIRECTION":"UN","MASTER_ID":18857,"ec":"1.14.14.138","compounds":"lithocholate + O2 + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxylithocholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":21833,"RHEA_ID":18858,"DIRECTION":"LR","MASTER_ID":18857,"metacyc":"1.14.13.94-RXN","compounds":"lithocholate + O2 + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxylithocholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":21834,"RHEA_ID":18859,"compounds":"6beta-hydroxylithocholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => lithocholate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":21835,"RHEA_ID":29465,"DIRECTION":"RL","MASTER_ID":29463,"ecocyc":"TRANS-RXN-143","reactome":"R-HSA-1296037.1","compounds":"K(+)(out) => K(+)(in)"}
{"X":21836,"RHEA_ID":18861,"DIRECTION":"UN","MASTER_ID":18861,"ec":"2.1.1.69","compounds":"a 5-hydroxyfurocoumarin + S-adenosyl-L-methionine = a 5-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine"}
{"X":21837,"RHEA_ID":18862,"DIRECTION":"LR","MASTER_ID":18861,"metacyc":"RXN-8448","compounds":"a 5-hydroxyfurocoumarin + S-adenosyl-L-methionine => a 5-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine"}
{"X":21838,"RHEA_ID":18863,"compounds":"a 5-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine => a 5-hydroxyfurocoumarin + S-adenosyl-L-methionine"}
{"X":21839,"RHEA_ID":29465,"DIRECTION":"RL","MASTER_ID":29463,"ecocyc":"TRANS-RXN-143","reactome":"R-HSA-1296043.1","compounds":"K(+)(out) => K(+)(in)"}
{"X":21840,"RHEA_ID":18865,"DIRECTION":"UN","MASTER_ID":18865,"ec":"2.3.1.168","compounds":"(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2-methylpropanoyl-CoA = (R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysyl-[protein] + CoA"}
{"X":21841,"RHEA_ID":18866,"DIRECTION":"LR","MASTER_ID":18865,"metacyc":"2.3.1.168-RXN","compounds":"(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2-methylpropanoyl-CoA => (R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysyl-[protein] + CoA"}
{"X":21842,"RHEA_ID":18867,"compounds":"(R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysyl-[protein] + CoA => (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2-methylpropanoyl-CoA"}
{"X":21843,"RHEA_ID":29465,"DIRECTION":"RL","MASTER_ID":29463,"ecocyc":"TRANS-RXN-143","reactome":"R-HSA-1296045.1","compounds":"K(+)(out) => K(+)(in)"}
{"X":21844,"RHEA_ID":18869,"DIRECTION":"UN","MASTER_ID":18869,"ec":"2.7.1.53","compounds":"ATP + L-xylulose = ADP + H(+) + L-xylulose 5-phosphate"}
{"X":21845,"RHEA_ID":18870,"DIRECTION":"LR","MASTER_ID":18869,"ecocyc":"LYXK-RXN","metacyc":"LYXK-RXN","compounds":"ATP + L-xylulose => ADP + H(+) + L-xylulose 5-phosphate"}
{"X":21846,"RHEA_ID":18871,"compounds":"ADP + H(+) + L-xylulose 5-phosphate => ATP + L-xylulose"}
{"X":21847,"RHEA_ID":29467,"compounds":"H(+)(out) + K(+)(in) = H(+)(in) + K(+)(out)"}
{"X":21848,"RHEA_ID":18873,"DIRECTION":"UN","MASTER_ID":18873,"ec":"4.5.1.2","compounds":"3-chloro-D-alanine + H2O = chloride + H(+) + NH4(+) + pyruvate"}
{"X":21849,"RHEA_ID":18874,"compounds":"3-chloro-D-alanine + H2O => chloride + H(+) + NH4(+) + pyruvate"}
{"X":21850,"RHEA_ID":18875,"compounds":"chloride + H(+) + NH4(+) + pyruvate => 3-chloro-D-alanine + H2O"}
{"X":21851,"RHEA_ID":18877,"DIRECTION":"UN","MASTER_ID":18877,"ec":"2.1.1.39","compounds":"myo-inositol + S-adenosyl-L-methionine = 1D-3-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine"}
{"X":21852,"RHEA_ID":18878,"DIRECTION":"LR","MASTER_ID":18877,"metacyc":"MYO-INOSITOL-1-O-METHYLTRANSFERASE-RXN","compounds":"myo-inositol + S-adenosyl-L-methionine => 1D-3-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine"}
{"X":21853,"RHEA_ID":18879,"compounds":"1D-3-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine => myo-inositol + S-adenosyl-L-methionine"}
{"X":21854,"RHEA_ID":29475,"DIRECTION":"UN","MASTER_ID":29475,"ec":"4.2.3.63","compounds":"(2E,6E)-farnesyl diphosphate = (+)-cubenene + diphosphate"}
{"X":21855,"RHEA_ID":18881,"DIRECTION":"UN","MASTER_ID":18881,"ec":"6.3.2.18","compounds":"ATP + histamine + L-glutamate = ADP + H(+) + N(alpha)-gamma-L-glutamylhistamine + phosphate"}
{"X":21856,"RHEA_ID":18882,"DIRECTION":"LR","MASTER_ID":18881,"metacyc":"GAMMA-GLUTAMYLHISTAMINE-SYNTHASE-RXN","compounds":"ATP + histamine + L-glutamate => ADP + H(+) + N(alpha)-gamma-L-glutamylhistamine + phosphate"}
{"X":21857,"RHEA_ID":18883,"compounds":"ADP + H(+) + N(alpha)-gamma-L-glutamylhistamine + phosphate => ATP + histamine + L-glutamate"}
{"X":21858,"RHEA_ID":18884,"compounds":"ATP + histamine + L-glutamate <=> ADP + H(+) + N(alpha)-gamma-L-glutamylhistamine + phosphate"}
{"X":21859,"RHEA_ID":18885,"DIRECTION":"UN","MASTER_ID":18885,"ec":"1.1.1.271","compounds":"GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH"}
{"X":21860,"RHEA_ID":18886,"compounds":"GDP-beta-L-fucose + NADP(+) => GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH"}
{"X":21861,"RHEA_ID":18887,"DIRECTION":"RL","MASTER_ID":18885,"ecocyc":"1.1.1.271-RXN","metacyc":"1.1.1.271-RXN","compounds":"GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH => GDP-beta-L-fucose + NADP(+)"}
{"X":21862,"RHEA_ID":29483,"DIRECTION":"UN","MASTER_ID":29483,"ec":"4.2.3.198","compounds":"(2E,6E)-farnesyl diphosphate = (+)-beta-selinene + diphosphate"}
{"X":21863,"RHEA_ID":18889,"DIRECTION":"UN","MASTER_ID":18889,"ec":"2.4.1.15","compounds":"D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + H(+) + UDP"}
{"X":21864,"RHEA_ID":18890,"DIRECTION":"LR","MASTER_ID":18889,"ecocyc":"TREHALOSE6PSYN-RXN","metacyc":"TREHALOSE6PSYN-RXN","compounds":"D-glucose 6-phosphate + UDP-alpha-D-glucose => alpha,alpha-trehalose 6-phosphate + H(+) + UDP"}
{"X":21865,"RHEA_ID":18891,"compounds":"alpha,alpha-trehalose 6-phosphate + H(+) + UDP => D-glucose 6-phosphate + UDP-alpha-D-glucose"}
{"X":21866,"RHEA_ID":39403,"compounds":"(2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH = (19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+)"}
{"X":21867,"RHEA_ID":18893,"DIRECTION":"UN","MASTER_ID":18893,"ec":"2.4.1.239","compounds":"a flavonol 3-O-beta-D-glucoside + UDP-alpha-D-glucose = a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP"}
{"X":21868,"RHEA_ID":18894,"DIRECTION":"LR","MASTER_ID":18893,"metacyc":"2.4.1.239-RXN","compounds":"a flavonol 3-O-beta-D-glucoside + UDP-alpha-D-glucose => a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP"}
{"X":21869,"RHEA_ID":18895,"compounds":"a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP => a flavonol 3-O-beta-D-glucoside + UDP-alpha-D-glucose"}
{"X":21870,"RHEA_ID":39407,"compounds":"3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+)"}
{"X":21871,"RHEA_ID":18897,"DIRECTION":"UN","MASTER_ID":18897,"ec":"1.21.99.3","compounds":"3,3',5'-triiodo-L-thyronine + A + H(+) + iodide = AH2 + L-thyroxine"}
{"X":21872,"RHEA_ID":18898,"compounds":"3,3',5'-triiodo-L-thyronine + A + H(+) + iodide => AH2 + L-thyroxine"}
{"X":21873,"RHEA_ID":18899,"DIRECTION":"RL","MASTER_ID":18897,"metacyc":"1.97.1.11-RXN","compounds":"AH2 + L-thyroxine => 3,3',5'-triiodo-L-thyronine + A + H(+) + iodide"}
{"X":21874,"RHEA_ID":39411,"compounds":"(3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA = (2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H2O"}
{"X":21875,"RHEA_ID":18901,"DIRECTION":"UN","MASTER_ID":18901,"ec":"3.5.1.64","metacyc":"3.5.1.64-RXN","compounds":"H(+) + H2O + N-benzyloxycarbonyl-L-leucine = benzyl alcohol + CO2 + L-leucine"}
{"X":21876,"RHEA_ID":18902,"compounds":"H(+) + H2O + N-benzyloxycarbonyl-L-leucine => benzyl alcohol + CO2 + L-leucine"}
{"X":21877,"RHEA_ID":18903,"compounds":"benzyl alcohol + CO2 + L-leucine => H(+) + H2O + N-benzyloxycarbonyl-L-leucine"}
{"X":21878,"RHEA_ID":39415,"compounds":"(2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH = (21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+)"}
{"X":21879,"RHEA_ID":18905,"DIRECTION":"UN","MASTER_ID":18905,"ec":"3.11.1.1","compounds":"H2O + phosphonoacetaldehyde = acetaldehyde + H(+) + phosphate"}
{"X":21880,"RHEA_ID":18906,"DIRECTION":"LR","MASTER_ID":18905,"macie":"M0181","compounds":"H2O + phosphonoacetaldehyde => acetaldehyde + H(+) + phosphate"}
{"X":21881,"RHEA_ID":18907,"compounds":"acetaldehyde + H(+) + phosphate => H2O + phosphonoacetaldehyde"}
{"X":21882,"RHEA_ID":18909,"DIRECTION":"UN","MASTER_ID":18909,"ec":"2.1.1.136","compounds":"2,4,6-trichlorophenol + S-adenosyl-L-methionine = 2,4,6-trichloroanisole + S-adenosyl-L-homocysteine"}
{"X":21883,"RHEA_ID":18910,"DIRECTION":"LR","MASTER_ID":18909,"metacyc":"2.1.1.136-RXN","compounds":"2,4,6-trichlorophenol + S-adenosyl-L-methionine => 2,4,6-trichloroanisole + S-adenosyl-L-homocysteine"}
{"X":21884,"RHEA_ID":18911,"compounds":"2,4,6-trichloroanisole + S-adenosyl-L-homocysteine => 2,4,6-trichlorophenol + S-adenosyl-L-methionine"}
{"X":21885,"RHEA_ID":39423,"compounds":"(3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA = (2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H2O"}
{"X":21886,"RHEA_ID":18913,"DIRECTION":"UN","MASTER_ID":18913,"ec":"2.4.99.6","compounds":"a neolactoside nLc4Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + CMP + H(+)"}
{"X":21887,"RHEA_ID":18913,"DIRECTION":"UN","MASTER_ID":18913,"ec":"2.4.99.10","compounds":"a neolactoside nLc4Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + CMP + H(+)"}
{"X":21888,"RHEA_ID":18914,"DIRECTION":"LR","MASTER_ID":18913,"metacyc":"2.4.99.10-RXN","compounds":"a neolactoside nLc4Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + CMP + H(+)"}
{"X":21889,"RHEA_ID":18915,"compounds":"a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + CMP + H(+) => a neolactoside nLc4Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate"}
{"X":21890,"RHEA_ID":29512,"DIRECTION":"LR","MASTER_ID":29511,"metacyc":"RXN-8608","compounds":"(2E,6E)-farnesyl diphosphate => (+)-valencene + diphosphate"}
{"X":21891,"RHEA_ID":18917,"compounds":"5alpha-cholest-7-en-3beta-ol + H(+) + NADPH + O2 = cholesta-5,7-dien-3beta-ol + 2 H2O + NADP(+)"}
{"X":21892,"RHEA_ID":18918,"compounds":"5alpha-cholest-7-en-3beta-ol + H(+) + NADPH + O2 => cholesta-5,7-dien-3beta-ol + 2 H2O + NADP(+)"}
{"X":21893,"RHEA_ID":18919,"compounds":"cholesta-5,7-dien-3beta-ol + 2 H2O + NADP(+) => 5alpha-cholest-7-en-3beta-ol + H(+) + NADPH + O2"}
{"X":21894,"RHEA_ID":29516,"DIRECTION":"LR","MASTER_ID":29515,"metacyc":"RXN-5462","compounds":"beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose => alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)"}
{"X":21895,"RHEA_ID":18921,"compounds":"5alpha-cholest-7-en-3beta-ol + H(+) + NADH + O2 = cholesta-5,7-dien-3beta-ol + 2 H2O + NAD(+)"}
{"X":21896,"RHEA_ID":18922,"compounds":"5alpha-cholest-7-en-3beta-ol + H(+) + NADH + O2 => cholesta-5,7-dien-3beta-ol + 2 H2O + NAD(+)"}
{"X":21897,"RHEA_ID":18923,"compounds":"cholesta-5,7-dien-3beta-ol + 2 H2O + NAD(+) => 5alpha-cholest-7-en-3beta-ol + H(+) + NADH + O2"}
{"X":21898,"RHEA_ID":18925,"DIRECTION":"UN","MASTER_ID":18925,"ec":"1.1.1.20","metacyc":"GLUCURONOLACTONE-REDUCTASE-RXN","compounds":"L-gulono-1,4-lactone + NADP(+) = D-glucurono-3,6-lactone + H(+) + NADPH"}
{"X":21899,"RHEA_ID":18926,"compounds":"L-gulono-1,4-lactone + NADP(+) => D-glucurono-3,6-lactone + H(+) + NADPH"}
{"X":21900,"RHEA_ID":18927,"compounds":"D-glucurono-3,6-lactone + H(+) + NADPH => L-gulono-1,4-lactone + NADP(+)"}
{"X":21901,"RHEA_ID":29523,"DIRECTION":"UN","MASTER_ID":29523,"ec":"2.4.1.131","compounds":"alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose = alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H(+)"}
{"X":21902,"RHEA_ID":18929,"DIRECTION":"UN","MASTER_ID":18929,"ec":"1.14.99.35","compounds":"AH2 + O2 + thiophene-2-carbonyl-CoA = 5-hydroxythiophene-2-carbonyl-CoA + A + H(+) + H2O"}
{"X":21903,"RHEA_ID":18930,"DIRECTION":"LR","MASTER_ID":18929,"metacyc":"1.14.99.35-RXN","compounds":"AH2 + O2 + thiophene-2-carbonyl-CoA => 5-hydroxythiophene-2-carbonyl-CoA + A + H(+) + H2O"}
{"X":21904,"RHEA_ID":18931,"compounds":"5-hydroxythiophene-2-carbonyl-CoA + A + H(+) + H2O => AH2 + O2 + thiophene-2-carbonyl-CoA"}
{"X":21905,"RHEA_ID":29527,"DIRECTION":"UN","MASTER_ID":29527,"ec":"2.4.1.258","compounds":"alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate = alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+)"}
{"X":21906,"RHEA_ID":18933,"DIRECTION":"UN","MASTER_ID":18933,"ec":"4.2.1.107","compounds":"(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O"}
{"X":21907,"RHEA_ID":18934,"DIRECTION":"LR","MASTER_ID":18933,"metacyc":"RXN-9847","compounds":"(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA => (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O"}
{"X":21908,"RHEA_ID":18935,"compounds":"(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O => (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA"}
{"X":21909,"RHEA_ID":18937,"DIRECTION":"UN","MASTER_ID":18937,"ec":"3.5.1.97","compounds":"an N-acyl-L-homoserine lactone + H2O = a carboxylate + L-homoserine lactone"}
{"X":21910,"RHEA_ID":18938,"DIRECTION":"LR","MASTER_ID":18937,"metacyc":"3.5.1.97-RXN","compounds":"an N-acyl-L-homoserine lactone + H2O => a carboxylate + L-homoserine lactone"}
{"X":21911,"RHEA_ID":18939,"compounds":"a carboxylate + L-homoserine lactone => an N-acyl-L-homoserine lactone + H2O"}
{"X":21912,"RHEA_ID":18941,"DIRECTION":"UN","MASTER_ID":18941,"ec":"1.1.1.413","compounds":"a (3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one + NADP(+) = a (3R,4R)-3-alkanoyl-4-(hydroxymethyl)oxolan-2-one + H(+) + NADPH"}
{"X":21913,"RHEA_ID":18942,"compounds":"a (3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one + NADP(+) => a (3R,4R)-3-alkanoyl-4-(hydroxymethyl)oxolan-2-one + H(+) + NADPH"}
{"X":21914,"RHEA_ID":18943,"DIRECTION":"RL","MASTER_ID":18941,"metacyc":"RXN-18649","compounds":"a (3R,4R)-3-alkanoyl-4-(hydroxymethyl)oxolan-2-one + H(+) + NADPH => a (3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one + NADP(+)"}
{"X":21915,"RHEA_ID":18945,"DIRECTION":"UN","MASTER_ID":18945,"ec":"1.14.11.2","compounds":"2-oxoglutarate + L-prolyl-[procollagen] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[procollagen]"}
{"X":21916,"RHEA_ID":18946,"DIRECTION":"LR","MASTER_ID":18945,"metacyc":"1.14.11.2-RXN","compounds":"2-oxoglutarate + L-prolyl-[procollagen] + O2 => CO2 + succinate + trans-4-hydroxy-L-prolyl-[procollagen]"}
{"X":21917,"RHEA_ID":18947,"compounds":"CO2 + succinate + trans-4-hydroxy-L-prolyl-[procollagen] => 2-oxoglutarate + L-prolyl-[procollagen] + O2"}
{"X":21918,"RHEA_ID":29543,"DIRECTION":"UN","MASTER_ID":29543,"ec":"2.4.1.256","compounds":"alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate = alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+)"}
{"X":21919,"RHEA_ID":18949,"DIRECTION":"UN","MASTER_ID":18949,"ec":"1.14.14.106","compounds":"O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha,13alpha-diol"}
{"X":21920,"RHEA_ID":18950,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha,13alpha-diol"}
{"X":21921,"RHEA_ID":18951,"compounds":"H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha,13alpha-diol => O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol"}
{"X":21922,"RHEA_ID":29547,"compounds":"H2O + UDP-N-acetyl-alpha-D-glucosamine = 2 H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UMP"}
{"X":21923,"RHEA_ID":18953,"DIRECTION":"UN","MASTER_ID":18953,"ec":"1.1.1.153","compounds":"L-erythro-7,8-dihydrobiopterin + NADP(+) = H(+) + NADPH + sepiapterin"}
{"X":21924,"RHEA_ID":18954,"compounds":"L-erythro-7,8-dihydrobiopterin + NADP(+) => H(+) + NADPH + sepiapterin"}
{"X":21925,"RHEA_ID":18955,"compounds":"H(+) + NADPH + sepiapterin => L-erythro-7,8-dihydrobiopterin + NADP(+)"}
{"X":21926,"RHEA_ID":29551,"compounds":"H2O + UDP-alpha-D-glucose = alpha-D-galactose 1-phosphate + 2 H(+) + UMP"}
{"X":21927,"RHEA_ID":18957,"DIRECTION":"UN","MASTER_ID":18957,"ec":"1.14.14.53","compounds":"(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":21928,"RHEA_ID":18958,"DIRECTION":"LR","MASTER_ID":18957,"metacyc":"RXN-10746","compounds":"(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] => (1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":21929,"RHEA_ID":18959,"compounds":"(1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":21930,"RHEA_ID":29555,"compounds":"H2O + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + 2 H(+) + UMP"}
{"X":21931,"RHEA_ID":18961,"compounds":"D-allose + L-lysyl-[protein] = H2O + N(6)-(D-psicosyl)-L-lysyl-[protein]"}
{"X":21932,"RHEA_ID":18962,"compounds":"D-allose + L-lysyl-[protein] => H2O + N(6)-(D-psicosyl)-L-lysyl-[protein]"}
{"X":21933,"RHEA_ID":18963,"compounds":"H2O + N(6)-(D-psicosyl)-L-lysyl-[protein] => D-allose + L-lysyl-[protein]"}
{"X":21934,"RHEA_ID":18964,"compounds":"D-allose + L-lysyl-[protein] <=> H2O + N(6)-(D-psicosyl)-L-lysyl-[protein]"}
{"X":21935,"RHEA_ID":18965,"DIRECTION":"UN","MASTER_ID":18965,"ec":"4.2.1.75","compounds":"hydroxymethylbilane = H2O + uroporphyrinogen III"}
{"X":21936,"RHEA_ID":18966,"DIRECTION":"LR","MASTER_ID":18965,"macie":"M0204","reactome":"R-HSA-189488.1","compounds":"hydroxymethylbilane => H2O + uroporphyrinogen III"}
{"X":21937,"RHEA_ID":18967,"compounds":"H2O + uroporphyrinogen III => hydroxymethylbilane"}
{"X":21938,"RHEA_ID":29563,"DIRECTION":"UN","MASTER_ID":29563,"ec":"6.3.2.45","compounds":"ATP + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate"}
{"X":21939,"RHEA_ID":18969,"DIRECTION":"UN","MASTER_ID":18969,"ec":"4.1.1.106","compounds":"a long-chain fatty acid + H(+) + hnu = a long-chain alkane + CO2"}
{"X":21940,"RHEA_ID":18970,"DIRECTION":"LR","MASTER_ID":18969,"metacyc":"RXN-19209","compounds":"a long-chain fatty acid + H(+) + hnu => a long-chain alkane + CO2"}
{"X":21941,"RHEA_ID":18971,"compounds":"a long-chain alkane + CO2 => a long-chain fatty acid + H(+) + hnu"}
{"X":21942,"RHEA_ID":18973,"DIRECTION":"UN","MASTER_ID":18973,"ec":"1.14.11.20","compounds":"2-oxoglutarate + deacetoxyvindoline + O2 = 4-O-deacetylvindoline + CO2 + succinate"}
{"X":21943,"RHEA_ID":18974,"DIRECTION":"LR","MASTER_ID":18973,"metacyc":"1.14.11.20-RXN","compounds":"2-oxoglutarate + deacetoxyvindoline + O2 => 4-O-deacetylvindoline + CO2 + succinate"}
{"X":21944,"RHEA_ID":18975,"compounds":"4-O-deacetylvindoline + CO2 + succinate => 2-oxoglutarate + deacetoxyvindoline + O2"}
{"X":21945,"RHEA_ID":29571,"compounds":"H(+)(in) + L-idonate(in) = H(+)(out) + L-idonate(out)"}
{"X":21946,"RHEA_ID":18977,"DIRECTION":"UN","MASTER_ID":18977,"ec":"1.1.5.3","compounds":"a quinone + sn-glycerol 3-phosphate = a quinol + dihydroxyacetone phosphate"}
{"X":21947,"RHEA_ID":18978,"DIRECTION":"LR","MASTER_ID":18977,"metacyc":"RXN-15745","compounds":"a quinone + sn-glycerol 3-phosphate => a quinol + dihydroxyacetone phosphate"}
{"X":21948,"RHEA_ID":18979,"compounds":"a quinol + dihydroxyacetone phosphate => a quinone + sn-glycerol 3-phosphate"}
{"X":21949,"RHEA_ID":29575,"compounds":"L-serine(in) + Na(+)(in) = L-serine(out) + Na(+)(out)"}
{"X":21950,"RHEA_ID":18981,"DIRECTION":"UN","MASTER_ID":18981,"ec":"1.1.1.168","compounds":"(R)-pantolactone + NADP(+) = 2-dehydropantolactone + H(+) + NADPH"}
{"X":21951,"RHEA_ID":18981,"DIRECTION":"UN","MASTER_ID":18981,"ec":"1.1.1.214","compounds":"(R)-pantolactone + NADP(+) = 2-dehydropantolactone + H(+) + NADPH"}
{"X":21952,"RHEA_ID":18981,"DIRECTION":"UN","MASTER_ID":18981,"ec":"1.1.1.358","compounds":"(R)-pantolactone + NADP(+) = 2-dehydropantolactone + H(+) + NADPH"}
{"X":21953,"RHEA_ID":18982,"compounds":"(R)-pantolactone + NADP(+) => 2-dehydropantolactone + H(+) + NADPH"}
{"X":21954,"RHEA_ID":18983,"DIRECTION":"RL","MASTER_ID":18981,"metacyc":"1.1.1.168-RXN","compounds":"2-dehydropantolactone + H(+) + NADPH => (R)-pantolactone + NADP(+)"}
{"X":21955,"RHEA_ID":18983,"DIRECTION":"RL","MASTER_ID":18981,"metacyc":"DEHYDROPANTLACRED-RXN","compounds":"2-dehydropantolactone + H(+) + NADPH => (R)-pantolactone + NADP(+)"}
{"X":21956,"RHEA_ID":29580,"DIRECTION":"LR","MASTER_ID":29579,"reactome":"R-HSA-435349.1","compounds":"Fe(2+)(in) + H(+)(in) => Fe(2+)(out) + H(+)(out)"}
{"X":21957,"RHEA_ID":29581,"DIRECTION":"RL","MASTER_ID":29579,"ecocyc":"RXN0-2421","compounds":"Fe(2+)(out) + H(+)(out) => Fe(2+)(in) + H(+)(in)"}
{"X":21958,"RHEA_ID":18985,"DIRECTION":"UN","MASTER_ID":18985,"ec":"5.4.4.2","compounds":"chorismate = isochorismate"}
{"X":21959,"RHEA_ID":18986,"DIRECTION":"LR","MASTER_ID":18985,"macie":"M0325","compounds":"chorismate => isochorismate"}
{"X":21960,"RHEA_ID":18987,"compounds":"isochorismate => chorismate"}
{"X":21961,"RHEA_ID":29585,"compounds":"guanosine(out) + H(+)(in) => guanosine(in) + H(+)(out)"}
{"X":21962,"RHEA_ID":18989,"DIRECTION":"UN","MASTER_ID":18989,"ec":"4.1.1.14","metacyc":"VALINE-DECARBOXYLASE-RXN","compounds":"H(+) + L-valine = 2-methylpropan-1-amine + CO2"}
{"X":21963,"RHEA_ID":18990,"compounds":"H(+) + L-valine => 2-methylpropan-1-amine + CO2"}
{"X":21964,"RHEA_ID":18991,"compounds":"2-methylpropan-1-amine + CO2 => H(+) + L-valine"}
{"X":21965,"RHEA_ID":18993,"DIRECTION":"UN","MASTER_ID":18993,"ec":"1.13.11.45","compounds":"(9Z,12Z)-octadecadienoate + O2 = (11S)-hydroperoxy-(9Z,12Z)-octadecadienoate"}
{"X":21966,"RHEA_ID":18994,"DIRECTION":"LR","MASTER_ID":18993,"metacyc":"1.13.11.45-RXN","compounds":"(9Z,12Z)-octadecadienoate + O2 => (11S)-hydroperoxy-(9Z,12Z)-octadecadienoate"}
{"X":21967,"RHEA_ID":18995,"compounds":"(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2"}
{"X":21968,"RHEA_ID":29593,"DIRECTION":"RL","MASTER_ID":29591,"metacyc":"RXN-12148","compounds":"H(+) + NADPH + sulfoacetaldehyde => 2-hydroxyethane-1-sulfonate + NADP(+)"}
{"X":21969,"RHEA_ID":18997,"DIRECTION":"UN","MASTER_ID":18997,"ec":"2.7.7.15","compounds":"CTP + H(+) + phosphocholine = CDP-choline + diphosphate"}
{"X":21970,"RHEA_ID":18998,"DIRECTION":"LR","MASTER_ID":18997,"metacyc":"2.7.7.15-RXN","compounds":"CTP + H(+) + phosphocholine => CDP-choline + diphosphate"}
{"X":21971,"RHEA_ID":18999,"compounds":"CDP-choline + diphosphate => CTP + H(+) + phosphocholine"}
{"X":21972,"RHEA_ID":29597,"compounds":"H(+) + NADPH + sulfoacetyl-CoA => CoA + NADP(+) + sulfoacetaldehyde"}
{"X":21973,"RHEA_ID":19009,"DIRECTION":"UN","MASTER_ID":19009,"ec":"3.7.1.5","compounds":"a 3-acylpyruvate + H2O = a carboxylate + H(+) + pyruvate"}
{"X":21974,"RHEA_ID":19010,"DIRECTION":"LR","MASTER_ID":19009,"metacyc":"ACYLPYRUVATE-HYDROLASE-RXN","compounds":"a 3-acylpyruvate + H2O => a carboxylate + H(+) + pyruvate"}
{"X":21975,"RHEA_ID":19011,"compounds":"a carboxylate + H(+) + pyruvate => a 3-acylpyruvate + H2O"}
{"X":21976,"RHEA_ID":19013,"DIRECTION":"UN","MASTER_ID":19013,"ec":"3.6.1.39","compounds":"dTTP + H2O = dTDP + H(+) + phosphate"}
{"X":21977,"RHEA_ID":19014,"DIRECTION":"LR","MASTER_ID":19013,"metacyc":"THYMIDINE-TRIPHOSPHATASE-RXN","compounds":"dTTP + H2O => dTDP + H(+) + phosphate"}
{"X":21978,"RHEA_ID":19015,"compounds":"dTDP + H(+) + phosphate => dTTP + H2O"}
{"X":21979,"RHEA_ID":29605,"DIRECTION":"RL","MASTER_ID":29603,"metacyc":"OHBENZCOARED-RXN","compounds":"4-hydroxybenzoyl-CoA + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] => benzoyl-CoA + H2O + oxidized 2[4Fe-4S]-[ferredoxin]"}
{"X":21980,"RHEA_ID":19017,"DIRECTION":"UN","MASTER_ID":19017,"ec":"4.2.1.93","compounds":"(6S)-NADHX + ATP = ADP + H(+) + NADH + phosphate"}
{"X":21981,"RHEA_ID":19018,"DIRECTION":"LR","MASTER_ID":19017,"metacyc":"4.2.1.93-RXN","compounds":"(6S)-NADHX + ATP => ADP + H(+) + NADH + phosphate"}
{"X":21982,"RHEA_ID":19019,"compounds":"ADP + H(+) + NADH + phosphate => (6S)-NADHX + ATP"}
{"X":21983,"RHEA_ID":29609,"compounds":"H(+) + NADH + 2 nitric oxide => H2O + NAD(+) + nitrous oxide"}
{"X":21984,"RHEA_ID":19021,"DIRECTION":"UN","MASTER_ID":19021,"ec":"2.4.1.40","compounds":"an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-N-acetyl-alpha-D-galactosamine = an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP"}
{"X":21985,"RHEA_ID":19022,"DIRECTION":"LR","MASTER_ID":19021,"metacyc":"2.4.1.40-RXN","compounds":"an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-N-acetyl-alpha-D-galactosamine => an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP"}
{"X":21986,"RHEA_ID":19023,"compounds":"an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP => an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-N-acetyl-alpha-D-galactosamine"}
{"X":21987,"RHEA_ID":29613,"compounds":"H(+) + NADPH + 2 nitric oxide => H2O + NADP(+) + nitrous oxide"}
{"X":21988,"RHEA_ID":19025,"compounds":"H2O + L-aspartate + O2 = H2O2 + NH4(+) + oxaloacetate"}
{"X":21989,"RHEA_ID":19026,"compounds":"H2O + L-aspartate + O2 => H2O2 + NH4(+) + oxaloacetate"}
{"X":21990,"RHEA_ID":19027,"compounds":"H2O2 + NH4(+) + oxaloacetate => H2O + L-aspartate + O2"}
{"X":21991,"RHEA_ID":29616,"compounds":"alpha-maltotriose + beta-maltose => alpha-maltotetraose + beta-D-glucose"}
{"X":21992,"RHEA_ID":19029,"DIRECTION":"UN","MASTER_ID":19029,"ec":"3.5.1.54","compounds":"3 H(+) + H2O + urea-1-carboxylate = 2 CO2 + 2 NH4(+)"}
{"X":21993,"RHEA_ID":19030,"DIRECTION":"LR","MASTER_ID":19029,"metacyc":"ALLOPHANATE-HYDROLASE-RXN","compounds":"3 H(+) + H2O + urea-1-carboxylate => 2 CO2 + 2 NH4(+)"}
{"X":21994,"RHEA_ID":19031,"compounds":"2 CO2 + 2 NH4(+) => 3 H(+) + H2O + urea-1-carboxylate"}
{"X":21995,"RHEA_ID":19033,"DIRECTION":"UN","MASTER_ID":19033,"ec":"5.1.3.8","compounds":"an N-acyl-D-glucosamine = an N-acyl-D-mannosamine"}
{"X":21996,"RHEA_ID":19034,"compounds":"an N-acyl-D-glucosamine => an N-acyl-D-mannosamine"}
{"X":21997,"RHEA_ID":19035,"compounds":"an N-acyl-D-mannosamine => an N-acyl-D-glucosamine"}
{"X":21998,"RHEA_ID":19037,"DIRECTION":"UN","MASTER_ID":19037,"ec":"3.3.2.10","compounds":"an epoxide + H2O = an ethanediol"}
{"X":21999,"RHEA_ID":19038,"compounds":"an epoxide + H2O => an ethanediol"}
{"X":22000,"RHEA_ID":19039,"compounds":"an ethanediol => an epoxide + H2O"}
{"X":22001,"RHEA_ID":19041,"DIRECTION":"UN","MASTER_ID":19041,"ec":"1.14.14.29","compounds":"(25R)-cholest-5-ene-3beta,26-diol + O2 + reduced [NADPH--hemoprotein reductase] = (25R)-cholest-5-en-3beta,7alpha,26-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":22002,"RHEA_ID":19042,"DIRECTION":"LR","MASTER_ID":19041,"metacyc":"1.14.13.60-RXN","compounds":"(25R)-cholest-5-ene-3beta,26-diol + O2 + reduced [NADPH--hemoprotein reductase] => (25R)-cholest-5-en-3beta,7alpha,26-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":22003,"RHEA_ID":19042,"DIRECTION":"LR","MASTER_ID":19041,"metacyc":"RXN-7981","compounds":"(25R)-cholest-5-ene-3beta,26-diol + O2 + reduced [NADPH--hemoprotein reductase] => (25R)-cholest-5-en-3beta,7alpha,26-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":22004,"RHEA_ID":19043,"compounds":"(25R)-cholest-5-en-3beta,7alpha,26-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (25R)-cholest-5-ene-3beta,26-diol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":22005,"RHEA_ID":29633,"compounds":"alpha-D-glucose + alpha-maltotriose => alpha-maltotetraose + H2O"}
{"X":22006,"RHEA_ID":19045,"DIRECTION":"UN","MASTER_ID":19045,"ec":"2.3.1.182","compounds":"acetyl-CoA + H2O + pyruvate = (3R)-citramalate + CoA + H(+)"}
{"X":22007,"RHEA_ID":19046,"compounds":"acetyl-CoA + H2O + pyruvate => (3R)-citramalate + CoA + H(+)"}
{"X":22008,"RHEA_ID":19047,"compounds":"(3R)-citramalate + CoA + H(+) => acetyl-CoA + H2O + pyruvate"}
{"X":22009,"RHEA_ID":29637,"compounds":"alpha-D-glucose + alpha-maltotetraose => alpha-maltopentaose + H2O"}
{"X":22010,"RHEA_ID":19049,"DIRECTION":"UN","MASTER_ID":19049,"ec":"2.7.1.81","compounds":"(5R)-5-hydroxy-L-lysine + GTP = (5R)-5-phosphooxy-L-lysine + GDP + H(+)"}
{"X":22011,"RHEA_ID":19050,"compounds":"(5R)-5-hydroxy-L-lysine + GTP => (5R)-5-phosphooxy-L-lysine + GDP + H(+)"}
{"X":22012,"RHEA_ID":19051,"compounds":"(5R)-5-phosphooxy-L-lysine + GDP + H(+) => (5R)-5-hydroxy-L-lysine + GTP"}
{"X":22013,"RHEA_ID":29641,"compounds":"alpha-D-glucose + alpha-maltopentaose => alpha-maltohexaose + H2O"}
{"X":22014,"RHEA_ID":19053,"DIRECTION":"UN","MASTER_ID":19053,"ec":"3.5.4.27","compounds":"5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = H(+) + N(5)-formyl-5,6,7,8-tetrahydromethanopterin"}
{"X":22015,"RHEA_ID":19054,"compounds":"5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O => H(+) + N(5)-formyl-5,6,7,8-tetrahydromethanopterin"}
{"X":22016,"RHEA_ID":19055,"compounds":"H(+) + N(5)-formyl-5,6,7,8-tetrahydromethanopterin => 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O"}
{"X":22017,"RHEA_ID":29645,"compounds":"alpha-D-glucose + alpha-maltohexaose => alpha-maltoheptaose + H2O"}
{"X":22018,"RHEA_ID":19057,"DIRECTION":"UN","MASTER_ID":19057,"ec":"1.11.1.12","compounds":"a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O"}
{"X":22019,"RHEA_ID":19058,"DIRECTION":"LR","MASTER_ID":19057,"metacyc":"1.11.1.12-RXN","compounds":"a hydroperoxy polyunsaturated fatty acid + 2 glutathione => a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O"}
{"X":22020,"RHEA_ID":19059,"compounds":"a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O => a hydroperoxy polyunsaturated fatty acid + 2 glutathione"}
{"X":22021,"RHEA_ID":29649,"compounds":"alpha-D-glucose 1-phosphate + alpha-maltotetraose => alpha-maltopentaose + phosphate"}
{"X":22022,"RHEA_ID":19061,"DIRECTION":"UN","MASTER_ID":19061,"ec":"1.7.1.2","compounds":"H2O + NADP(+) + nitrite = H(+) + NADPH + nitrate"}
{"X":22023,"RHEA_ID":19061,"DIRECTION":"UN","MASTER_ID":19061,"ec":"1.7.1.3","compounds":"H2O + NADP(+) + nitrite = H(+) + NADPH + nitrate"}
{"X":22024,"RHEA_ID":19062,"compounds":"H2O + NADP(+) + nitrite => H(+) + NADPH + nitrate"}
{"X":22025,"RHEA_ID":19063,"DIRECTION":"RL","MASTER_ID":19061,"metacyc":"NITRATE-REDUCTASE-NADPH-RXN","compounds":"H(+) + NADPH + nitrate => H2O + NADP(+) + nitrite"}
{"X":22026,"RHEA_ID":19063,"DIRECTION":"RL","MASTER_ID":19061,"metacyc":"NITRATE-REDUCTASE-NADPORNOPH-RXN","compounds":"H(+) + NADPH + nitrate => H2O + NADP(+) + nitrite"}
{"X":22027,"RHEA_ID":19069,"DIRECTION":"UN","MASTER_ID":19069,"ec":"4.4.1.5","compounds":"(R)-S-lactoylglutathione = glutathione + methylglyoxal"}
{"X":22028,"RHEA_ID":19070,"compounds":"(R)-S-lactoylglutathione => glutathione + methylglyoxal"}
{"X":22029,"RHEA_ID":19071,"DIRECTION":"RL","MASTER_ID":19069,"ecocyc":"GLYOXI-RXN","macie":"M0032","reactome":"R-HSA-5694071.1","compounds":"glutathione + methylglyoxal => (R)-S-lactoylglutathione"}
{"X":22030,"RHEA_ID":29659,"compounds":"O-acetyl-L-serine(in) = O-acetyl-L-serine(out)"}
{"X":22031,"RHEA_ID":19073,"DIRECTION":"UN","MASTER_ID":19073,"ec":"2.7.11.10","compounds":"[I-kappa-B protein]-L-serine + ATP = [I-kappa-B protein]-O-phospho-L-serine + ADP + H(+)"}
{"X":22032,"RHEA_ID":19074,"compounds":"[I-kappa-B protein]-L-serine + ATP => [I-kappa-B protein]-O-phospho-L-serine + ADP + H(+)"}
{"X":22033,"RHEA_ID":19075,"compounds":"[I-kappa-B protein]-O-phospho-L-serine + ADP + H(+) => [I-kappa-B protein]-L-serine + ATP"}
{"X":22034,"RHEA_ID":19076,"DIRECTION":"BI","MASTER_ID":19073,"metacyc":"2.7.11.10-RXN","compounds":"[I-kappa-B protein]-L-serine + ATP <=> [I-kappa-B protein]-O-phospho-L-serine + ADP + H(+)"}
{"X":22035,"RHEA_ID":19077,"compounds":"H2O + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein] = 3-deoxyglucosone + L-lysyl-[protein] + phosphate"}
{"X":22036,"RHEA_ID":19078,"compounds":"H2O + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein] => 3-deoxyglucosone + L-lysyl-[protein] + phosphate"}
{"X":22037,"RHEA_ID":19079,"compounds":"3-deoxyglucosone + L-lysyl-[protein] + phosphate => H2O + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein]"}
{"X":22038,"RHEA_ID":19080,"compounds":"H2O + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein] <=> 3-deoxyglucosone + L-lysyl-[protein] + phosphate"}
{"X":22039,"RHEA_ID":19081,"DIRECTION":"UN","MASTER_ID":19081,"ec":"3.8.1.5","compounds":"1-haloalkane + H2O = a halide anion + a primary alcohol + H(+)"}
{"X":22040,"RHEA_ID":19082,"DIRECTION":"LR","MASTER_ID":19081,"metacyc":"HALOALKANE-DEHALOGENASE-RXN","compounds":"1-haloalkane + H2O => a halide anion + a primary alcohol + H(+)"}
{"X":22041,"RHEA_ID":19083,"compounds":"a halide anion + a primary alcohol + H(+) => 1-haloalkane + H2O"}
{"X":22042,"RHEA_ID":19085,"DIRECTION":"UN","MASTER_ID":19085,"ec":"2.6.1.33","compounds":"2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate"}
{"X":22043,"RHEA_ID":19086,"compounds":"2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-glucose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate"}
{"X":22044,"RHEA_ID":19087,"compounds":"dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate => 2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-glucose"}
{"X":22045,"RHEA_ID":29670,"DIRECTION":"BI","MASTER_ID":29667,"ecocyc":"TRANS-RXN-145","compounds":"H2O(in) <=> H2O(out)"}
{"X":22046,"RHEA_ID":19089,"compounds":"S-adenosyl-L-methionine + uroporphyrinogen III = H(+) + precorrin-1 + S-adenosyl-L-homocysteine"}
{"X":22047,"RHEA_ID":19090,"DIRECTION":"LR","MASTER_ID":19089,"ecocyc":"UROPORIIIMETHYLTRANSA-RXN","metacyc":"UROPORIIIMETHYLTRANSA-RXN","compounds":"S-adenosyl-L-methionine + uroporphyrinogen III => H(+) + precorrin-1 + S-adenosyl-L-homocysteine"}
{"X":22048,"RHEA_ID":19091,"compounds":"H(+) + precorrin-1 + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uroporphyrinogen III"}
{"X":22049,"RHEA_ID":29672,"DIRECTION":"LR","MASTER_ID":29671,"ecocyc":"TRANS-RXN-144","reactome":"R-HSA-8949178.1","compounds":"Ca(2+)(in) => Ca(2+)(out)"}
{"X":22050,"RHEA_ID":19093,"DIRECTION":"UN","MASTER_ID":19093,"ec":"4.1.1.111","compounds":"2 H(+) + siroheme = 12,18-didecarboxysiroheme + 2 CO2"}
{"X":22051,"RHEA_ID":19094,"DIRECTION":"LR","MASTER_ID":19093,"metacyc":"RXN-15805","compounds":"2 H(+) + siroheme => 12,18-didecarboxysiroheme + 2 CO2"}
{"X":22052,"RHEA_ID":19095,"compounds":"12,18-didecarboxysiroheme + 2 CO2 => 2 H(+) + siroheme"}
{"X":22053,"RHEA_ID":29672,"DIRECTION":"LR","MASTER_ID":29671,"ecocyc":"TRANS-RXN-144","reactome":"R-HSA-5577213.5","compounds":"Ca(2+)(in) => Ca(2+)(out)"}
{"X":22054,"RHEA_ID":19097,"compounds":"AH2 + 2 ATP + benzoyl-CoA + 2 H2O = A + 2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + 2 H(+) + 2 phosphate"}
{"X":22055,"RHEA_ID":19098,"compounds":"AH2 + 2 ATP + benzoyl-CoA + 2 H2O => A + 2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + 2 H(+) + 2 phosphate"}
{"X":22056,"RHEA_ID":19099,"compounds":"A + 2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + 2 H(+) + 2 phosphate => AH2 + 2 ATP + benzoyl-CoA + 2 H2O"}
{"X":22057,"RHEA_ID":29672,"DIRECTION":"LR","MASTER_ID":29671,"ecocyc":"TRANS-RXN-144","reactome":"R-HSA-139855.2","compounds":"Ca(2+)(in) => Ca(2+)(out)"}
{"X":22058,"RHEA_ID":19101,"DIRECTION":"UN","MASTER_ID":19101,"ec":"1.1.1.165","metacyc":"2-ALKYN-1-OL-DEHYDROGENASE-RXN","compounds":"2-butyne-1,4-diol + NAD(+) = 4-hydroxy-2-butynal + H(+) + NADH"}
{"X":22059,"RHEA_ID":19102,"compounds":"2-butyne-1,4-diol + NAD(+) => 4-hydroxy-2-butynal + H(+) + NADH"}
{"X":22060,"RHEA_ID":19103,"compounds":"4-hydroxy-2-butynal + H(+) + NADH => 2-butyne-1,4-diol + NAD(+)"}
{"X":22061,"RHEA_ID":19105,"DIRECTION":"UN","MASTER_ID":19105,"ec":"1.2.1.19","compounds":"4-aminobutanal + H2O + NAD(+) = 4-aminobutanoate + 2 H(+) + NADH"}
{"X":22062,"RHEA_ID":19106,"DIRECTION":"LR","MASTER_ID":19105,"ecocyc":"AMINOBUTDEHYDROG-RXN","metacyc":"AMINOBUTDEHYDROG-RXN","compounds":"4-aminobutanal + H2O + NAD(+) => 4-aminobutanoate + 2 H(+) + NADH"}
{"X":22063,"RHEA_ID":19107,"compounds":"4-aminobutanoate + 2 H(+) + NADH => 4-aminobutanal + H2O + NAD(+)"}
{"X":22064,"RHEA_ID":29673,"DIRECTION":"RL","MASTER_ID":29671,"reactome":"R-HSA-418309.1","compounds":"Ca(2+)(out) => Ca(2+)(in)"}
{"X":22065,"RHEA_ID":19109,"DIRECTION":"UN","MASTER_ID":19109,"ec":"2.3.1.143","compounds":"1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose = 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + D-glucose + H(+)"}
{"X":22066,"RHEA_ID":19110,"DIRECTION":"LR","MASTER_ID":19109,"metacyc":"2.3.1.143-RXN","compounds":"1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose => 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + D-glucose + H(+)"}
{"X":22067,"RHEA_ID":19111,"compounds":"1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + D-glucose + H(+) => 1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose"}
{"X":22068,"RHEA_ID":29675,"compounds":"glycerol(in) = glycerol(out)"}
{"X":22069,"RHEA_ID":19113,"compounds":"(8Z,11Z,14Z)-heptadecatrienal + A + H2O = (8Z,11Z,14Z)-heptadecatrienoate + AH2 + H(+)"}
{"X":22070,"RHEA_ID":19114,"compounds":"(8Z,11Z,14Z)-heptadecatrienal + A + H2O => (8Z,11Z,14Z)-heptadecatrienoate + AH2 + H(+)"}
{"X":22071,"RHEA_ID":19115,"compounds":"(8Z,11Z,14Z)-heptadecatrienoate + AH2 + H(+) => (8Z,11Z,14Z)-heptadecatrienal + A + H2O"}
{"X":22072,"RHEA_ID":19116,"compounds":"(8Z,11Z,14Z)-heptadecatrienal + A + H2O <=> (8Z,11Z,14Z)-heptadecatrienoate + AH2 + H(+)"}
{"X":22073,"RHEA_ID":19117,"DIRECTION":"UN","MASTER_ID":19117,"ec":"1.14.17.1","compounds":"dopamine + 2 L-ascorbate + O2 = (R)-noradrenaline + H2O + 2 monodehydro-L-ascorbate radical"}
{"X":22074,"RHEA_ID":19118,"DIRECTION":"LR","MASTER_ID":19117,"metacyc":"DOPAMINE-BETA-MONOOXYGENASE-RXN","compounds":"dopamine + 2 L-ascorbate + O2 => (R)-noradrenaline + H2O + 2 monodehydro-L-ascorbate radical"}
{"X":22075,"RHEA_ID":19119,"compounds":"(R)-noradrenaline + H2O + 2 monodehydro-L-ascorbate radical => dopamine + 2 L-ascorbate + O2"}
{"X":22076,"RHEA_ID":29681,"DIRECTION":"RL","MASTER_ID":29679,"reactome":"R-HSA-6803255.1","compounds":"formate(out) => formate(in)"}
{"X":22077,"RHEA_ID":19121,"DIRECTION":"UN","MASTER_ID":19121,"ec":"7.6.2.3","compounds":"an S-substituted glutathione(in) + ATP + H2O = ADP + an S-substituted glutathione(out) + H(+) + phosphate"}
{"X":22078,"RHEA_ID":19122,"DIRECTION":"LR","MASTER_ID":19121,"metacyc":"TRANS-RXN-358","compounds":"an S-substituted glutathione(in) + ATP + H2O => ADP + an S-substituted glutathione(out) + H(+) + phosphate"}
{"X":22079,"RHEA_ID":19123,"compounds":"ADP + an S-substituted glutathione(out) + H(+) + phosphate => an S-substituted glutathione(in) + ATP + H2O"}
{"X":22080,"RHEA_ID":19124,"compounds":"an S-substituted glutathione(in) + ATP + H2O <=> ADP + an S-substituted glutathione(out) + H(+) + phosphate"}
{"X":22081,"RHEA_ID":19125,"DIRECTION":"UN","MASTER_ID":19125,"ec":"2.6.1.45","compounds":"glyoxylate + L-serine = 3-hydroxypyruvate + glycine"}
{"X":22082,"RHEA_ID":19126,"compounds":"glyoxylate + L-serine => 3-hydroxypyruvate + glycine"}
{"X":22083,"RHEA_ID":19127,"compounds":"3-hydroxypyruvate + glycine => glyoxylate + L-serine"}
{"X":22084,"RHEA_ID":29689,"compounds":"alpha-D-glucose 1-phosphate + alpha-maltohexaose => alpha-maltoheptaose + phosphate"}
{"X":22085,"RHEA_ID":19129,"DIRECTION":"UN","MASTER_ID":19129,"ec":"2.7.1.145","compounds":"ATP + thymidine = ADP + dTMP + H(+)"}
{"X":22086,"RHEA_ID":19129,"DIRECTION":"UN","MASTER_ID":19129,"ec":"2.7.1.21","compounds":"ATP + thymidine = ADP + dTMP + H(+)"}
{"X":22087,"RHEA_ID":19130,"DIRECTION":"LR","MASTER_ID":19129,"ecocyc":"THYKI-RXN","metacyc":"THYKI-RXN","reactome":"R-HSA-73632.3","compounds":"ATP + thymidine => ADP + dTMP + H(+)"}
{"X":22088,"RHEA_ID":19131,"compounds":"ADP + dTMP + H(+) => ATP + thymidine"}
{"X":22089,"RHEA_ID":29694,"DIRECTION":"BI","MASTER_ID":29691,"ecocyc":"RXN0-5182","metacyc":"RXN0-5182","compounds":"alpha-maltotetraose + phosphate <=> alpha-D-glucose 1-phosphate + alpha-maltotriose"}
{"X":22090,"RHEA_ID":19133,"DIRECTION":"UN","MASTER_ID":19133,"ec":"2.6.1.26","compounds":"2-oxoglutarate + 3,3',5-triiodo-L-thyronine = 3,5,3'-triiodothyropyruvate + L-glutamate"}
{"X":22091,"RHEA_ID":19134,"compounds":"2-oxoglutarate + 3,3',5-triiodo-L-thyronine => 3,5,3'-triiodothyropyruvate + L-glutamate"}
{"X":22092,"RHEA_ID":19135,"compounds":"3,5,3'-triiodothyropyruvate + L-glutamate => 2-oxoglutarate + 3,3',5-triiodo-L-thyronine"}
{"X":22093,"RHEA_ID":29697,"DIRECTION":"RL","MASTER_ID":29695,"ecocyc":"TRANS-RXN0-455","compounds":"cob(I)inamide(out) => cob(I)inamide(in)"}
{"X":22094,"RHEA_ID":19137,"DIRECTION":"UN","MASTER_ID":19137,"ec":"1.14.99.11","compounds":"17beta-estradiol + AH2 + O2 = 6beta-hydroxyestradiol-17beta + A + H2O"}
{"X":22095,"RHEA_ID":19138,"DIRECTION":"LR","MASTER_ID":19137,"metacyc":"ESTRADIOL-6-BETA-MONOOXYGENASE-RXN","compounds":"17beta-estradiol + AH2 + O2 => 6beta-hydroxyestradiol-17beta + A + H2O"}
{"X":22096,"RHEA_ID":19139,"compounds":"6beta-hydroxyestradiol-17beta + A + H2O => 17beta-estradiol + AH2 + O2"}
{"X":22097,"RHEA_ID":29701,"DIRECTION":"RL","MASTER_ID":29699,"ecocyc":"TRANS-RXN0-273","compounds":"dimethyl sulfoxide(out) => dimethyl sulfoxide(in)"}
{"X":22098,"RHEA_ID":19141,"compounds":"all-trans-retinol = 11-cis-retinol"}
{"X":22099,"RHEA_ID":19142,"compounds":"all-trans-retinol => 11-cis-retinol"}
{"X":22100,"RHEA_ID":19143,"compounds":"11-cis-retinol => all-trans-retinol"}
{"X":22101,"RHEA_ID":29704,"DIRECTION":"LR","MASTER_ID":29703,"ecocyc":"TRANS-RXN0-269","reactome":"R-HSA-352107.1","compounds":"L-valine(in) => L-valine(out)"}
{"X":22102,"RHEA_ID":19145,"DIRECTION":"UN","MASTER_ID":19145,"ec":"3.1.6.3","compounds":"D-glucose 6-sulfate + H2O = D-glucose + H(+) + sulfate"}
{"X":22103,"RHEA_ID":19146,"DIRECTION":"LR","MASTER_ID":19145,"metacyc":"GLYCOSULFATASE-RXN","compounds":"D-glucose 6-sulfate + H2O => D-glucose + H(+) + sulfate"}
{"X":22104,"RHEA_ID":19147,"compounds":"D-glucose + H(+) + sulfate => D-glucose 6-sulfate + H2O"}
{"X":22105,"RHEA_ID":29706,"compounds":"L-valine(in) <=> L-valine(out)"}
{"X":22106,"RHEA_ID":19149,"DIRECTION":"UN","MASTER_ID":19149,"ec":"2.4.2.31","compounds":"L-arginyl-[protein] + NAD(+) = H(+) + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide"}
{"X":22107,"RHEA_ID":19150,"compounds":"L-arginyl-[protein] + NAD(+) => H(+) + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide"}
{"X":22108,"RHEA_ID":19151,"compounds":"H(+) + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide => L-arginyl-[protein] + NAD(+)"}
{"X":22109,"RHEA_ID":29710,"compounds":"1,6-anhydro-N-acetyl-beta-muramate(in) <=> 1,6-anhydro-N-acetyl-beta-muramate(out)"}
{"X":22110,"RHEA_ID":19153,"DIRECTION":"UN","MASTER_ID":19153,"ec":"2.4.2.25","compounds":"apigenin 7-O-beta-D-glucoside + UDP-alpha-D-apiose = 7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone + H(+) + UDP"}
{"X":22111,"RHEA_ID":19154,"DIRECTION":"LR","MASTER_ID":19153,"metacyc":"FLAVONE-APIOSYLTRANSFERASE-RXN","compounds":"apigenin 7-O-beta-D-glucoside + UDP-alpha-D-apiose => 7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone + H(+) + UDP"}
{"X":22112,"RHEA_ID":19155,"compounds":"7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone + H(+) + UDP => apigenin 7-O-beta-D-glucoside + UDP-alpha-D-apiose"}
{"X":22113,"RHEA_ID":29714,"compounds":"cadaverine(in) + H(+)(in) <=> cadaverine(out) + H(+)(out)"}
{"X":22114,"RHEA_ID":19157,"DIRECTION":"UN","MASTER_ID":19157,"ec":"4.2.1.82","compounds":"D-xylonate = 2-dehydro-3-deoxy-D-arabinonate + H2O"}
{"X":22115,"RHEA_ID":19158,"DIRECTION":"LR","MASTER_ID":19157,"metacyc":"XYLONATE-DEHYDRATASE-RXN","compounds":"D-xylonate => 2-dehydro-3-deoxy-D-arabinonate + H2O"}
{"X":22116,"RHEA_ID":19159,"compounds":"2-dehydro-3-deoxy-D-arabinonate + H2O => D-xylonate"}
{"X":22117,"RHEA_ID":29718,"compounds":"2-hydroxyethane-1-sulfonate + FMNH2 + O2 <=> FMN + glycolaldehyde + 2 H(+) + H2O + sulfite"}
{"X":22118,"RHEA_ID":19161,"compounds":"2 2-aminophenol + O2 = 2 6-iminocyclohexa-2,4-dienone + 2 H2O"}
{"X":22119,"RHEA_ID":19162,"compounds":"2 2-aminophenol + O2 => 2 6-iminocyclohexa-2,4-dienone + 2 H2O"}
{"X":22120,"RHEA_ID":19163,"compounds":"2 6-iminocyclohexa-2,4-dienone + 2 H2O => 2 2-aminophenol + O2"}
{"X":22121,"RHEA_ID":19164,"compounds":"2 2-aminophenol + O2 <=> 2 6-iminocyclohexa-2,4-dienone + 2 H2O"}
{"X":22122,"RHEA_ID":19165,"DIRECTION":"UN","MASTER_ID":19165,"ec":"2.4.1.208","compounds":"a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose = 1,2-diacyl-3-O-[alpha-D-glucosyl-(1-> 2)-alpha-D-glucosyl]-sn-glycerol + H(+) + UDP"}
{"X":22123,"RHEA_ID":19166,"compounds":"a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose => 1,2-diacyl-3-O-[alpha-D-glucosyl-(1-> 2)-alpha-D-glucosyl]-sn-glycerol + H(+) + UDP"}
{"X":22124,"RHEA_ID":19167,"compounds":"1,2-diacyl-3-O-[alpha-D-glucosyl-(1-> 2)-alpha-D-glucosyl]-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose"}
{"X":22125,"RHEA_ID":29725,"DIRECTION":"RL","MASTER_ID":29723,"ecocyc":"RXN0-1982","reactome":"R-HSA-6784434.2","compounds":"glyoxylate(out) => glyoxylate(in)"}
{"X":22126,"RHEA_ID":19169,"DIRECTION":"UN","MASTER_ID":19169,"ec":"4.3.1.17","compounds":"L-serine = NH4(+) + pyruvate"}
{"X":22127,"RHEA_ID":19170,"DIRECTION":"LR","MASTER_ID":19169,"ecocyc":"4.3.1.17-RXN","macie":"M0186","metacyc":"4.3.1.17-RXN","reactome":"R-HSA-9034539.2","compounds":"L-serine => NH4(+) + pyruvate"}
{"X":22128,"RHEA_ID":19171,"compounds":"NH4(+) + pyruvate => L-serine"}
{"X":22129,"RHEA_ID":19173,"DIRECTION":"UN","MASTER_ID":19173,"ec":"1.14.12.12","compounds":"H(+) + NADH + naphthalene + O2 = (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+)"}
{"X":22130,"RHEA_ID":19174,"DIRECTION":"LR","MASTER_ID":19173,"metacyc":"NAPHTHALENE-12-DIOXYGENASE-RXN","compounds":"H(+) + NADH + naphthalene + O2 => (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+)"}
{"X":22131,"RHEA_ID":19175,"compounds":"(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+) => H(+) + NADH + naphthalene + O2"}
{"X":22132,"RHEA_ID":29732,"compounds":"beta-maltose(in) => beta-maltose(out)"}
{"X":22133,"RHEA_ID":19177,"DIRECTION":"UN","MASTER_ID":19177,"ec":"5.4.3.2","compounds":"L-lysine = (3S)-3,6-diaminohexanoate"}
{"X":22134,"RHEA_ID":19178,"DIRECTION":"LR","MASTER_ID":19177,"metacyc":"LYSINE-23-AMINOMUTASE-RXN","compounds":"L-lysine => (3S)-3,6-diaminohexanoate"}
{"X":22135,"RHEA_ID":19179,"compounds":"(3S)-3,6-diaminohexanoate => L-lysine"}
{"X":22136,"RHEA_ID":29736,"compounds":"butane-1-sulfonate + FMNH2 + O2 => butanal + FMN + 2 H(+) + H2O + sulfite"}
{"X":22137,"RHEA_ID":19181,"DIRECTION":"UN","MASTER_ID":19181,"ec":"1.3.8.9","compounds":"a very-long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a very-long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":22138,"RHEA_ID":19182,"DIRECTION":"LR","MASTER_ID":19181,"metacyc":"RXN-13451","compounds":"a very-long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => a very-long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":22139,"RHEA_ID":19183,"compounds":"a very-long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein] => a very-long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":22140,"RHEA_ID":19184,"compounds":"a very-long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> a very-long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":22141,"RHEA_ID":19185,"DIRECTION":"UN","MASTER_ID":19185,"ec":"2.3.3.11","compounds":"glyoxylate + H2O + propanoyl-CoA = 2-hydroxyglutarate + CoA + H(+)"}
{"X":22142,"RHEA_ID":19186,"DIRECTION":"LR","MASTER_ID":19185,"ecocyc":"HYDGLUTSYN-RXN","metacyc":"HYDGLUTSYN-RXN","compounds":"glyoxylate + H2O + propanoyl-CoA => 2-hydroxyglutarate + CoA + H(+)"}
{"X":22143,"RHEA_ID":19187,"compounds":"2-hydroxyglutarate + CoA + H(+) => glyoxylate + H2O + propanoyl-CoA"}
{"X":22144,"RHEA_ID":29744,"compounds":"2-phenylethylamine(in) => 2-phenylethylamine(out)"}
{"X":22145,"RHEA_ID":19189,"DIRECTION":"UN","MASTER_ID":19189,"ec":"1.2.4.1","compounds":"[dihydrolipoyllysine-residue acetyltransferase]-(R)-N(6)-lipoyl-L-lysine + H(+) + pyruvate = [dihydrolipoyllysine-residue acetyltransferase]-(R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysine + CO2"}
{"X":22146,"RHEA_ID":19190,"DIRECTION":"LR","MASTER_ID":19189,"ecocyc":"RXN0-1134","compounds":"[dihydrolipoyllysine-residue acetyltransferase]-(R)-N(6)-lipoyl-L-lysine + H(+) + pyruvate => [dihydrolipoyllysine-residue acetyltransferase]-(R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysine + CO2"}
{"X":22147,"RHEA_ID":19191,"compounds":"[dihydrolipoyllysine-residue acetyltransferase]-(R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysine + CO2 => [dihydrolipoyllysine-residue acetyltransferase]-(R)-N(6)-lipoyl-L-lysine + H(+) + pyruvate"}
{"X":22148,"RHEA_ID":19193,"DIRECTION":"UN","MASTER_ID":19193,"ec":"1.3.99.23","compounds":"A + all-trans-13,14-dihydroretinol = AH2 + all-trans-retinol"}
{"X":22149,"RHEA_ID":19194,"compounds":"A + all-trans-13,14-dihydroretinol => AH2 + all-trans-retinol"}
{"X":22150,"RHEA_ID":19195,"DIRECTION":"RL","MASTER_ID":19193,"metacyc":"1.3.99.23-RXN","compounds":"AH2 + all-trans-retinol => A + all-trans-13,14-dihydroretinol"}
{"X":22151,"RHEA_ID":29752,"compounds":"acetoacetate(in) => acetoacetate(out)"}
{"X":22152,"RHEA_ID":19197,"DIRECTION":"UN","MASTER_ID":19197,"ec":"2.7.7.51","compounds":"adenosine 5'-phosphosulfate + NH4(+) = adenosine 5'-phosphoramidate + 2 H(+) + sulfate"}
{"X":22153,"RHEA_ID":19198,"DIRECTION":"LR","MASTER_ID":19197,"metacyc":"2.7.7.51-RXN","compounds":"adenosine 5'-phosphosulfate + NH4(+) => adenosine 5'-phosphoramidate + 2 H(+) + sulfate"}
{"X":22154,"RHEA_ID":19199,"compounds":"adenosine 5'-phosphoramidate + 2 H(+) + sulfate => adenosine 5'-phosphosulfate + NH4(+)"}
{"X":22155,"RHEA_ID":29756,"DIRECTION":"LR","MASTER_ID":29755,"ecocyc":"TRANS-RXN0-278","compounds":"(R)-lipoate(in) => (R)-lipoate(out)"}
{"X":22156,"RHEA_ID":19201,"DIRECTION":"UN","MASTER_ID":19201,"ec":"2.7.1.145","compounds":"2'-deoxyguanosine + ATP = ADP + dGMP + H(+)"}
{"X":22157,"RHEA_ID":19201,"DIRECTION":"UN","MASTER_ID":19201,"ec":"2.7.1.113","compounds":"2'-deoxyguanosine + ATP = ADP + dGMP + H(+)"}
{"X":22158,"RHEA_ID":19202,"DIRECTION":"LR","MASTER_ID":19201,"metacyc":"DEOXYGUANOSINE-KINASE-RXN","compounds":"2'-deoxyguanosine + ATP => ADP + dGMP + H(+)"}
{"X":22159,"RHEA_ID":19203,"compounds":"ADP + dGMP + H(+) => 2'-deoxyguanosine + ATP"}
{"X":22160,"RHEA_ID":29761,"DIRECTION":"RL","MASTER_ID":29759,"ecocyc":"TRANS-RXN0-272","compounds":"octanoate(out) => octanoate(in)"}
{"X":22161,"RHEA_ID":19205,"DIRECTION":"UN","MASTER_ID":19205,"ec":"3.5.4.30","compounds":"dCTP + 2 H2O = diphosphate + dUMP + NH4(+)"}
{"X":22162,"RHEA_ID":19206,"DIRECTION":"LR","MASTER_ID":19205,"metacyc":"3.5.4.30-RXN","compounds":"dCTP + 2 H2O => diphosphate + dUMP + NH4(+)"}
{"X":22163,"RHEA_ID":19207,"compounds":"diphosphate + dUMP + NH4(+) => dCTP + 2 H2O"}
{"X":22164,"RHEA_ID":29765,"compounds":"ADP + H(+) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in) + phosphate => ATP + H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out)"}
{"X":22165,"RHEA_ID":19209,"DIRECTION":"UN","MASTER_ID":19209,"ec":"1.1.1.247","compounds":"codeine + NADP(+) = codeinone + H(+) + NADPH"}
{"X":22166,"RHEA_ID":19210,"compounds":"codeine + NADP(+) => codeinone + H(+) + NADPH"}
{"X":22167,"RHEA_ID":19211,"compounds":"codeinone + H(+) + NADPH => codeine + NADP(+)"}
{"X":22168,"RHEA_ID":29769,"compounds":"ADP + D-methionine(in) + H(+) + phosphate => ATP + D-methionine(out) + H2O"}
{"X":22169,"RHEA_ID":19213,"DIRECTION":"UN","MASTER_ID":19213,"ec":"2.3.1.80","compounds":"acetyl-CoA + an S-substituted L-cysteine = an N-acetyl-L-cysteine-S-conjugate + CoA + H(+)"}
{"X":22170,"RHEA_ID":19214,"DIRECTION":"LR","MASTER_ID":19213,"metacyc":"2.3.1.80-RXN","compounds":"acetyl-CoA + an S-substituted L-cysteine => an N-acetyl-L-cysteine-S-conjugate + CoA + H(+)"}
{"X":22171,"RHEA_ID":19215,"compounds":"an N-acetyl-L-cysteine-S-conjugate + CoA + H(+) => acetyl-CoA + an S-substituted L-cysteine"}
{"X":22172,"RHEA_ID":29773,"compounds":"ADP + arsenate(out) + H(+) + phosphate => arsenate(in) + ATP + H2O"}
{"X":22173,"RHEA_ID":19217,"DIRECTION":"UN","MASTER_ID":19217,"ec":"4.5.1.1","compounds":"1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H(+)"}
{"X":22174,"RHEA_ID":19218,"compounds":"1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane => 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H(+)"}
{"X":22175,"RHEA_ID":19219,"compounds":"1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H(+) => 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane"}
{"X":22176,"RHEA_ID":29777,"compounds":"ADP + alpha-D-ribose 1,5-bisphosphate + H(+) => alpha-D-ribose 1-phosphate + ATP"}
{"X":22177,"RHEA_ID":19221,"DIRECTION":"UN","MASTER_ID":19221,"ec":"1.2.98.1","compounds":"2 formaldehyde + H2O = formate + H(+) + methanol"}
{"X":22178,"RHEA_ID":19222,"compounds":"2 formaldehyde + H2O => formate + H(+) + methanol"}
{"X":22179,"RHEA_ID":19223,"compounds":"formate + H(+) + methanol => 2 formaldehyde + H2O"}
{"X":22180,"RHEA_ID":19225,"DIRECTION":"UN","MASTER_ID":19225,"ec":"1.97.1.4","compounds":"glycyl-[formate C-acetyltransferase] + reduced [flavodoxin] + S-adenosyl-L-methionine = 5'-deoxyadenosine + glycin-2-yl radical-[formate C-acetyltransferase] + H(+) + L-methionine + semiquinone [flavodoxin]"}
{"X":22181,"RHEA_ID":19226,"DIRECTION":"LR","MASTER_ID":19225,"metacyc":"TDCEACT-RXN","compounds":"glycyl-[formate C-acetyltransferase] + reduced [flavodoxin] + S-adenosyl-L-methionine => 5'-deoxyadenosine + glycin-2-yl radical-[formate C-acetyltransferase] + H(+) + L-methionine + semiquinone [flavodoxin]"}
{"X":22182,"RHEA_ID":19227,"compounds":"5'-deoxyadenosine + glycin-2-yl radical-[formate C-acetyltransferase] + H(+) + L-methionine + semiquinone [flavodoxin] => glycyl-[formate C-acetyltransferase] + reduced [flavodoxin] + S-adenosyl-L-methionine"}
{"X":22183,"RHEA_ID":29785,"compounds":"ADP + H(+) + L-cysteine(out) + phosphate => ATP + H2O + L-cysteine(in)"}
{"X":22184,"RHEA_ID":19229,"DIRECTION":"UN","MASTER_ID":19229,"ec":"1.2.1.30","compounds":"AMP + an aromatic aldehyde + diphosphate + NADP(+) = an aromatic carboxylate + ATP + H(+) + NADPH"}
{"X":22185,"RHEA_ID":19230,"compounds":"AMP + an aromatic aldehyde + diphosphate + NADP(+) => an aromatic carboxylate + ATP + H(+) + NADPH"}
{"X":22186,"RHEA_ID":19231,"DIRECTION":"RL","MASTER_ID":19229,"metacyc":"ARYL-ALDEHYDE-DEHYDROGENASE-NADP%2b-RXN","compounds":"an aromatic carboxylate + ATP + H(+) + NADPH => AMP + an aromatic aldehyde + diphosphate + NADP(+)"}
{"X":22187,"RHEA_ID":29789,"compounds":"ADP + glutathione(out) + H(+) + phosphate => ATP + glutathione(in) + H2O"}
{"X":22188,"RHEA_ID":19233,"DIRECTION":"UN","MASTER_ID":19233,"ec":"3.1.2.22","compounds":"H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein]"}
{"X":22189,"RHEA_ID":19234,"DIRECTION":"LR","MASTER_ID":19233,"metacyc":"3.1.2.22-RXN","compounds":"H2O + S-hexadecanoyl-L-cysteinyl-[protein] => H(+) + hexadecanoate + L-cysteinyl-[protein]"}
{"X":22190,"RHEA_ID":19235,"compounds":"H(+) + hexadecanoate + L-cysteinyl-[protein] => H2O + S-hexadecanoyl-L-cysteinyl-[protein]"}
{"X":22191,"RHEA_ID":19237,"DIRECTION":"UN","MASTER_ID":19237,"ec":"5.4.99.14","compounds":"4-carboxymethyl-4-methylbut-2-en-1,4-olide = 4-carboxymethyl-3-methylbut-2-en-1,4-olide"}
{"X":22192,"RHEA_ID":19238,"DIRECTION":"LR","MASTER_ID":19237,"metacyc":"5.4.99.14-RXN","compounds":"4-carboxymethyl-4-methylbut-2-en-1,4-olide => 4-carboxymethyl-3-methylbut-2-en-1,4-olide"}
{"X":22193,"RHEA_ID":19239,"compounds":"4-carboxymethyl-3-methylbut-2-en-1,4-olide => 4-carboxymethyl-4-methylbut-2-en-1,4-olide"}
{"X":22194,"RHEA_ID":29797,"compounds":"ADP(in) + H(+)(in) + phosphate(in) + Zn(2+)(in) => ATP(in) + H2O(in) + Zn(2+)(out)"}
{"X":22195,"RHEA_ID":19241,"compounds":"ent-kaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase] = ent-7alpha-hydroxykaur-16-en-19-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":22196,"RHEA_ID":19242,"DIRECTION":"LR","MASTER_ID":19241,"metacyc":"1.14.13.79-RXN","compounds":"ent-kaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase] => ent-7alpha-hydroxykaur-16-en-19-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":22197,"RHEA_ID":19243,"compounds":"ent-7alpha-hydroxykaur-16-en-19-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":22198,"RHEA_ID":29801,"compounds":"ADP + D-allose(in) + H(+) + phosphate => ATP + D-allose(out) + H2O"}
{"X":22199,"RHEA_ID":19245,"DIRECTION":"UN","MASTER_ID":19245,"ec":"5.4.4.1","compounds":"N-phenylhydroxylamine = 2-aminophenol"}
{"X":22200,"RHEA_ID":19246,"DIRECTION":"LR","MASTER_ID":19245,"metacyc":"5.4.4.1-RXN","compounds":"N-phenylhydroxylamine => 2-aminophenol"}
{"X":22201,"RHEA_ID":19247,"compounds":"2-aminophenol => N-phenylhydroxylamine"}
{"X":22202,"RHEA_ID":29805,"compounds":"ADP + H(+) + L-valine(out) + phosphate => ATP + H2O + L-valine(in)"}
{"X":22203,"RHEA_ID":19249,"DIRECTION":"UN","MASTER_ID":19249,"ec":"2.6.1.63","compounds":"glyoxylate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine"}
{"X":22204,"RHEA_ID":19250,"compounds":"glyoxylate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine"}
{"X":22205,"RHEA_ID":19251,"compounds":"4-(2-aminophenyl)-2,4-dioxobutanoate + glycine => glyoxylate + L-kynurenine"}
{"X":22206,"RHEA_ID":29809,"compounds":"ADP + H(+) + L-leucine(in) + phosphate => ATP + H2O + L-leucine(out)"}
{"X":22207,"RHEA_ID":19253,"DIRECTION":"UN","MASTER_ID":19253,"ec":"3.1.4.12","compounds":"H2O + sphingomyelin = an N-acylsphing-4-enine + H(+) + phosphocholine"}
{"X":22208,"RHEA_ID":19254,"DIRECTION":"LR","MASTER_ID":19253,"metacyc":"SPHINGOMYELIN-PHOSPHODIESTERASE-RXN","reactome":"R-HSA-193706.1","compounds":"H2O + sphingomyelin => an N-acylsphing-4-enine + H(+) + phosphocholine"}
{"X":22209,"RHEA_ID":19254,"DIRECTION":"LR","MASTER_ID":19253,"metacyc":"SPHINGOMYELIN-PHOSPHODIESTERASE-RXN","reactome":"R-HSA-1605797.1","compounds":"H2O + sphingomyelin => an N-acylsphing-4-enine + H(+) + phosphocholine"}
{"X":22210,"RHEA_ID":19255,"compounds":"an N-acylsphing-4-enine + H(+) + phosphocholine => H2O + sphingomyelin"}
{"X":22211,"RHEA_ID":19257,"DIRECTION":"UN","MASTER_ID":19257,"ec":"1.1.1.2","metacyc":"CARBONYL-REDUCTASE-NADPH-RXN","compounds":"a secondary alcohol + NADP(+) = a ketone + H(+) + NADPH"}
{"X":22212,"RHEA_ID":19257,"DIRECTION":"UN","MASTER_ID":19257,"ec":"1.1.1.184","metacyc":"CARBONYL-REDUCTASE-NADPH-RXN","compounds":"a secondary alcohol + NADP(+) = a ketone + H(+) + NADPH"}
{"X":22213,"RHEA_ID":19258,"compounds":"a secondary alcohol + NADP(+) => a ketone + H(+) + NADPH"}
{"X":22214,"RHEA_ID":19259,"compounds":"a ketone + H(+) + NADPH => a secondary alcohol + NADP(+)"}
{"X":22215,"RHEA_ID":19261,"DIRECTION":"UN","MASTER_ID":19261,"ec":"7.6.2.5","compounds":"ATP + H2O + heme b(in) = ADP + H(+) + heme b(out) + phosphate"}
{"X":22216,"RHEA_ID":19262,"DIRECTION":"LR","MASTER_ID":19261,"metacyc":"3.6.3.41-RXN","compounds":"ATP + H2O + heme b(in) => ADP + H(+) + heme b(out) + phosphate"}
{"X":22217,"RHEA_ID":19263,"compounds":"ADP + H(+) + heme b(out) + phosphate => ATP + H2O + heme b(in)"}
{"X":22218,"RHEA_ID":19264,"compounds":"ATP + H2O + heme b(in) <=> ADP + H(+) + heme b(out) + phosphate"}
{"X":22219,"RHEA_ID":19265,"DIRECTION":"UN","MASTER_ID":19265,"ec":"1.1.1.108","compounds":"carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH"}
{"X":22220,"RHEA_ID":19266,"compounds":"carnitine + NAD(+) => 3-dehydrocarnitine + H(+) + NADH"}
{"X":22221,"RHEA_ID":19267,"compounds":"3-dehydrocarnitine + H(+) + NADH => carnitine + NAD(+)"}
{"X":22222,"RHEA_ID":29824,"DIRECTION":"LR","MASTER_ID":29823,"reactome":"R-HSA-975449.1","compounds":"chloride(in) => chloride(out)"}
{"X":22223,"RHEA_ID":19269,"DIRECTION":"UN","MASTER_ID":19269,"ec":"6.2.1.31","compounds":"2-furoate + ATP + CoA = 2-furoyl-CoA + AMP + diphosphate"}
{"X":22224,"RHEA_ID":19270,"DIRECTION":"LR","MASTER_ID":19269,"metacyc":"2-FUROATE--COA-LIGASE-RXN","compounds":"2-furoate + ATP + CoA => 2-furoyl-CoA + AMP + diphosphate"}
{"X":22225,"RHEA_ID":19271,"compounds":"2-furoyl-CoA + AMP + diphosphate => 2-furoate + ATP + CoA"}
{"X":22226,"RHEA_ID":29825,"DIRECTION":"RL","MASTER_ID":29823,"ecocyc":"TRANS-RXN-139","reactome":"R-HSA-2744242.3","compounds":"chloride(out) => chloride(in)"}
{"X":22227,"RHEA_ID":19273,"DIRECTION":"UN","MASTER_ID":19273,"ec":"2.5.1.56","compounds":"H2O + N-acetyl-D-mannosamine + phosphoenolpyruvate = N-acetylneuraminate + phosphate"}
{"X":22228,"RHEA_ID":19274,"DIRECTION":"LR","MASTER_ID":19273,"metacyc":"N-ACETYLNEURAMINATE-SYNTHASE-RXN","compounds":"H2O + N-acetyl-D-mannosamine + phosphoenolpyruvate => N-acetylneuraminate + phosphate"}
{"X":22229,"RHEA_ID":19275,"compounds":"N-acetylneuraminate + phosphate => H2O + N-acetyl-D-mannosamine + phosphoenolpyruvate"}
{"X":22230,"RHEA_ID":29825,"DIRECTION":"RL","MASTER_ID":29823,"ecocyc":"TRANS-RXN-139","reactome":"R-HSA-2684901.3","compounds":"chloride(out) => chloride(in)"}
{"X":22231,"RHEA_ID":19277,"DIRECTION":"UN","MASTER_ID":19277,"ec":"6.1.1.26","compounds":"ATP + L-pyrrolysine + tRNA(Pyl) = AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl)"}
{"X":22232,"RHEA_ID":19278,"DIRECTION":"LR","MASTER_ID":19277,"metacyc":"6.1.1.26-RXN","compounds":"ATP + L-pyrrolysine + tRNA(Pyl) => AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl)"}
{"X":22233,"RHEA_ID":19279,"compounds":"AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl) => ATP + L-pyrrolysine + tRNA(Pyl)"}
{"X":22234,"RHEA_ID":29828,"DIRECTION":"LR","MASTER_ID":29827,"reactome":"R-HSA-442661.2","compounds":"Mg(2+)(in) => Mg(2+)(out)"}
{"X":22235,"RHEA_ID":19281,"DIRECTION":"UN","MASTER_ID":19281,"ec":"1.14.14.141","compounds":"(7S)-marmesin + O2 + reduced [NADPH--hemoprotein reductase] = acetone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + psoralen"}
{"X":22236,"RHEA_ID":19282,"DIRECTION":"LR","MASTER_ID":19281,"metacyc":"RXN-8386","compounds":"(7S)-marmesin + O2 + reduced [NADPH--hemoprotein reductase] => acetone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + psoralen"}
{"X":22237,"RHEA_ID":19283,"compounds":"acetone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + psoralen => (7S)-marmesin + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":22238,"RHEA_ID":29828,"DIRECTION":"LR","MASTER_ID":29827,"reactome":"R-HSA-5339538.1","compounds":"Mg(2+)(in) => Mg(2+)(out)"}
{"X":22239,"RHEA_ID":19285,"DIRECTION":"UN","MASTER_ID":19285,"ec":"2.3.1.83","metacyc":"2.3.1.83-RXN","compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + di-trans,poly-cis-dolichol = a 1-acyl-sn-glycero-3-phosphocholine + acyldolichol"}
{"X":22240,"RHEA_ID":19286,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + di-trans,poly-cis-dolichol => a 1-acyl-sn-glycero-3-phosphocholine + acyldolichol"}
{"X":22241,"RHEA_ID":19287,"compounds":"a 1-acyl-sn-glycero-3-phosphocholine + acyldolichol => a 1,2-diacyl-sn-glycero-3-phosphocholine + di-trans,poly-cis-dolichol"}
{"X":22242,"RHEA_ID":19289,"DIRECTION":"UN","MASTER_ID":19289,"ec":"3.1.3.24","compounds":"H2O + sucrose 6(F)-phosphate = phosphate + sucrose"}
{"X":22243,"RHEA_ID":19290,"DIRECTION":"LR","MASTER_ID":19289,"metacyc":"SUCROSE-PHOSPHATASE-RXN","compounds":"H2O + sucrose 6(F)-phosphate => phosphate + sucrose"}
{"X":22244,"RHEA_ID":19291,"compounds":"phosphate + sucrose => H2O + sucrose 6(F)-phosphate"}
{"X":22245,"RHEA_ID":29836,"compounds":"D-galactonate(in) + H(+)(in) => D-galactonate(out) + H(+)(out)"}
{"X":22246,"RHEA_ID":19293,"DIRECTION":"UN","MASTER_ID":19293,"ec":"2.7.1.94","compounds":"a monoacylglycerol + ATP = ADP + H(+) + monoacyl-sn-glycero-3-phosphate"}
{"X":22247,"RHEA_ID":19294,"compounds":"a monoacylglycerol + ATP => ADP + H(+) + monoacyl-sn-glycero-3-phosphate"}
{"X":22248,"RHEA_ID":19295,"compounds":"ADP + H(+) + monoacyl-sn-glycero-3-phosphate => a monoacylglycerol + ATP"}
{"X":22249,"RHEA_ID":19296,"compounds":"a monoacylglycerol + ATP <=> ADP + H(+) + monoacyl-sn-glycero-3-phosphate"}
{"X":22250,"RHEA_ID":19297,"DIRECTION":"UN","MASTER_ID":19297,"ec":"6.3.2.11","compounds":"ATP + beta-alanine + L-histidine = ADP + carnosine + H(+) + phosphate"}
{"X":22251,"RHEA_ID":19298,"DIRECTION":"LR","MASTER_ID":19297,"metacyc":"CARNOSINE-SYNTHASE-RXN","reactome":"R-HSA-6786245.1","compounds":"ATP + beta-alanine + L-histidine => ADP + carnosine + H(+) + phosphate"}
{"X":22252,"RHEA_ID":19299,"compounds":"ADP + carnosine + H(+) + phosphate => ATP + beta-alanine + L-histidine"}
{"X":22253,"RHEA_ID":29844,"compounds":"ATP + CoA + propanoate => ADP + phosphate + propanoyl-CoA"}
{"X":22254,"RHEA_ID":19301,"DIRECTION":"UN","MASTER_ID":19301,"ec":"2.1.1.8","compounds":"histamine + S-adenosyl-L-methionine = H(+) + N(tau)-methylhistamine + S-adenosyl-L-homocysteine"}
{"X":22255,"RHEA_ID":19302,"DIRECTION":"LR","MASTER_ID":19301,"metacyc":"HISTAMINE-N-METHYLTRANSFERASE-RXN","reactome":"R-HSA-175993.1","compounds":"histamine + S-adenosyl-L-methionine => H(+) + N(tau)-methylhistamine + S-adenosyl-L-homocysteine"}
{"X":22256,"RHEA_ID":19303,"compounds":"H(+) + N(tau)-methylhistamine + S-adenosyl-L-homocysteine => histamine + S-adenosyl-L-methionine"}
{"X":22257,"RHEA_ID":29848,"compounds":"(2E)-tetradecenoyl-CoA => (3Z)-tetradecenoyl-CoA"}
{"X":22258,"RHEA_ID":19305,"DIRECTION":"UN","MASTER_ID":19305,"ec":"2.3.1.151","compounds":"3-hydroxybenzoyl-CoA + 2 H(+) + 3 malonyl-CoA = 2,3',4,6-tetrahydroxybenzophenone + 3 CO2 + 4 CoA"}
{"X":22259,"RHEA_ID":19306,"DIRECTION":"LR","MASTER_ID":19305,"metacyc":"2.3.1.151-RXN","compounds":"3-hydroxybenzoyl-CoA + 2 H(+) + 3 malonyl-CoA => 2,3',4,6-tetrahydroxybenzophenone + 3 CO2 + 4 CoA"}
{"X":22260,"RHEA_ID":19307,"compounds":"2,3',4,6-tetrahydroxybenzophenone + 3 CO2 + 4 CoA => 3-hydroxybenzoyl-CoA + 2 H(+) + 3 malonyl-CoA"}
{"X":22261,"RHEA_ID":29852,"compounds":"H2O + UDP-N-acetyl-alpha-D-galactosamine => 2 H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UMP"}
{"X":22262,"RHEA_ID":19309,"DIRECTION":"UN","MASTER_ID":19309,"ec":"3.1.3.70","compounds":"2-O-(alpha-D-mannosyl)-3-phosphoglycerate + H2O = (2R)-2-O-(alpha-D-mannosyl)-glycerate + phosphate"}
{"X":22263,"RHEA_ID":19310,"DIRECTION":"LR","MASTER_ID":19309,"metacyc":"3.1.3.70-RXN","compounds":"2-O-(alpha-D-mannosyl)-3-phosphoglycerate + H2O => (2R)-2-O-(alpha-D-mannosyl)-glycerate + phosphate"}
{"X":22264,"RHEA_ID":19311,"compounds":"(2R)-2-O-(alpha-D-mannosyl)-glycerate + phosphate => 2-O-(alpha-D-mannosyl)-3-phosphoglycerate + H2O"}
{"X":22265,"RHEA_ID":29856,"compounds":"H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine => D-alanine + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate"}
{"X":22266,"RHEA_ID":19313,"DIRECTION":"UN","MASTER_ID":19313,"ec":"2.4.99.8","compounds":"an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP + H(+)"}
{"X":22267,"RHEA_ID":19314,"DIRECTION":"LR","MASTER_ID":19313,"metacyc":"2.4.99.8-RXN","compounds":"an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP-N-acetyl-beta-neuraminate => an N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP + H(+)"}
{"X":22268,"RHEA_ID":19315,"compounds":"an N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP + H(+) => an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP-N-acetyl-beta-neuraminate"}
{"X":22269,"RHEA_ID":29860,"DIRECTION":"LR","MASTER_ID":29859,"metacyc":"RXN0-6550","compounds":"5'-deoxyadenosine + H2O => 5-deoxy-alpha-D-ribose + adenine"}
{"X":22270,"RHEA_ID":19317,"DIRECTION":"UN","MASTER_ID":19317,"ec":"6.3.4.18","compounds":"5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate"}
{"X":22271,"RHEA_ID":19318,"DIRECTION":"LR","MASTER_ID":19317,"ecocyc":"RXN0-742","metacyc":"RXN0-742","compounds":"5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate => 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate"}
{"X":22272,"RHEA_ID":19319,"compounds":"5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate"}
{"X":22273,"RHEA_ID":29864,"DIRECTION":"LR","MASTER_ID":29863,"reactome":"R-HSA-1008248.3","compounds":"AMP + GTP => ADP + GDP"}
{"X":22274,"RHEA_ID":19321,"DIRECTION":"UN","MASTER_ID":19321,"ec":"4.1.2.24","metacyc":"DIMETHYLANILINE-N-OXIDE-ALDOLASE-RXN","compounds":"N,N-dimethylaniline N-oxide = formaldehyde + N-methylaniline"}
{"X":22275,"RHEA_ID":19322,"compounds":"N,N-dimethylaniline N-oxide => formaldehyde + N-methylaniline"}
{"X":22276,"RHEA_ID":19323,"compounds":"formaldehyde + N-methylaniline => N,N-dimethylaniline N-oxide"}
{"X":22277,"RHEA_ID":29868,"compounds":"AMP + ITP => ADP + IDP"}
{"X":22278,"RHEA_ID":19325,"DIRECTION":"UN","MASTER_ID":19325,"ec":"1.14.13.62","compounds":"H(+) + NADH + O2 + quinolin-4-ol = H2O + NAD(+) + quinoline-3,4-diol"}
{"X":22279,"RHEA_ID":19326,"DIRECTION":"LR","MASTER_ID":19325,"metacyc":"1.14.13.62-RXN","compounds":"H(+) + NADH + O2 + quinolin-4-ol => H2O + NAD(+) + quinoline-3,4-diol"}
{"X":22280,"RHEA_ID":19327,"compounds":"H2O + NAD(+) + quinoline-3,4-diol => H(+) + NADH + O2 + quinolin-4-ol"}
{"X":22281,"RHEA_ID":29872,"DIRECTION":"LR","MASTER_ID":29871,"ecocyc":"ABC-7-RXN","compounds":"ATP + H2O + thiosulfate(out) => ADP + H(+) + phosphate + thiosulfate(in)"}
{"X":22282,"RHEA_ID":19329,"DIRECTION":"UN","MASTER_ID":19329,"ec":"2.4.1.192","compounds":"nuatigenin + UDP-alpha-D-glucose = H(+) + nuatigenin 3-beta-D-glucopyranoside + UDP"}
{"X":22283,"RHEA_ID":19330,"DIRECTION":"LR","MASTER_ID":19329,"metacyc":"2.4.1.192-RXN","compounds":"nuatigenin + UDP-alpha-D-glucose => H(+) + nuatigenin 3-beta-D-glucopyranoside + UDP"}
{"X":22284,"RHEA_ID":19331,"compounds":"H(+) + nuatigenin 3-beta-D-glucopyranoside + UDP => nuatigenin + UDP-alpha-D-glucose"}
{"X":22285,"RHEA_ID":29876,"DIRECTION":"LR","MASTER_ID":29875,"ecocyc":"RXN-14136","metacyc":"RXN-14136","compounds":"H2O + sn-glycero-3-phospho-L-serine => H(+) + L-serine + sn-glycerol 3-phosphate"}
{"X":22286,"RHEA_ID":19333,"DIRECTION":"UN","MASTER_ID":19333,"ec":"4.1.1.8","compounds":"H(+) + oxalyl-CoA = CO2 + formyl-CoA"}
{"X":22287,"RHEA_ID":19334,"DIRECTION":"LR","MASTER_ID":19333,"ecocyc":"OXALYL-COA-DECARBOXYLASE-RXN","metacyc":"OXALYL-COA-DECARBOXYLASE-RXN","compounds":"H(+) + oxalyl-CoA => CO2 + formyl-CoA"}
{"X":22288,"RHEA_ID":19335,"compounds":"CO2 + formyl-CoA => H(+) + oxalyl-CoA"}
{"X":22289,"RHEA_ID":29880,"DIRECTION":"LR","MASTER_ID":29879,"ecocyc":"ABC-4-RXN","metacyc":"ABC-4-RXN","compounds":"ATP + H2O + L-arginine(out) => ADP + H(+) + L-arginine(in) + phosphate"}
{"X":22290,"RHEA_ID":19337,"DIRECTION":"UN","MASTER_ID":19337,"ec":"1.7.1.5","metacyc":"HYPONITRITE-REDUCTASE-RXN","compounds":"2 hydroxylamine + 2 NAD(+) = 2 H(+) + hyponitrous acid + 2 NADH"}
{"X":22291,"RHEA_ID":19338,"compounds":"2 hydroxylamine + 2 NAD(+) => 2 H(+) + hyponitrous acid + 2 NADH"}
{"X":22292,"RHEA_ID":19339,"compounds":"2 H(+) + hyponitrous acid + 2 NADH => 2 hydroxylamine + 2 NAD(+)"}
{"X":22293,"RHEA_ID":19341,"DIRECTION":"UN","MASTER_ID":19341,"ec":"1.14.15.3","compounds":"2 H(+) + O2 + octane + 2 reduced [rubredoxin] = H2O + octan-1-ol + 2 oxidized [rubredoxin]"}
{"X":22294,"RHEA_ID":19342,"DIRECTION":"LR","MASTER_ID":19341,"metacyc":"ALKANE-1-MONOOXYGENASE-RXN","compounds":"2 H(+) + O2 + octane + 2 reduced [rubredoxin] => H2O + octan-1-ol + 2 oxidized [rubredoxin]"}
{"X":22295,"RHEA_ID":19343,"compounds":"H2O + octan-1-ol + 2 oxidized [rubredoxin] => 2 H(+) + O2 + octane + 2 reduced [rubredoxin]"}
{"X":22296,"RHEA_ID":29888,"DIRECTION":"LR","MASTER_ID":29887,"ecocyc":"ABC-3-RXN","metacyc":"ABC-3-RXN","compounds":"ATP + H2O + L-lysine(out) => ADP + H(+) + L-lysine(in) + phosphate"}
{"X":22297,"RHEA_ID":19345,"DIRECTION":"UN","MASTER_ID":19345,"ec":"2.5.1.36","compounds":"(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate = (6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate"}
{"X":22298,"RHEA_ID":19346,"DIRECTION":"LR","MASTER_ID":19345,"metacyc":"RXN-4510","compounds":"(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate => (6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate"}
{"X":22299,"RHEA_ID":19347,"compounds":"(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate => (6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate"}
{"X":22300,"RHEA_ID":29892,"DIRECTION":"LR","MASTER_ID":29891,"ecocyc":"ABC-14-RXN","compounds":"ATP + H2O + L-histidine(out) => ADP + H(+) + L-histidine(in) + phosphate"}
{"X":22301,"RHEA_ID":19349,"DIRECTION":"UN","MASTER_ID":19349,"ec":"1.2.1.33","metacyc":"R-DEHYDROPANTOATE-DEHYDROGENASE-RXN","compounds":"(R)-4-dehydropantoate + H2O + NAD(+) = (R)-3,3-dimethylmalate + 2 H(+) + NADH"}
{"X":22302,"RHEA_ID":19350,"compounds":"(R)-4-dehydropantoate + H2O + NAD(+) => (R)-3,3-dimethylmalate + 2 H(+) + NADH"}
{"X":22303,"RHEA_ID":19351,"compounds":"(R)-3,3-dimethylmalate + 2 H(+) + NADH => (R)-4-dehydropantoate + H2O + NAD(+)"}
{"X":22304,"RHEA_ID":29896,"DIRECTION":"LR","MASTER_ID":29895,"ecocyc":"ABC-12-RXN","compounds":"ATP + H2O + L-glutamine(out) => ADP + H(+) + L-glutamine(in) + phosphate"}
{"X":22305,"RHEA_ID":19353,"DIRECTION":"UN","MASTER_ID":19353,"ec":"3.5.1.24","compounds":"glycocholate + H2O = cholate + glycine"}
{"X":22306,"RHEA_ID":19354,"DIRECTION":"LR","MASTER_ID":19353,"metacyc":"CHOLOYLGLYCINE-HYDROLASE-RXN","compounds":"glycocholate + H2O => cholate + glycine"}
{"X":22307,"RHEA_ID":19355,"compounds":"cholate + glycine => glycocholate + H2O"}
{"X":22308,"RHEA_ID":29899,"DIRECTION":"UN","MASTER_ID":29899,"ec":"7.5.2.10","compounds":"ATP + D-xylose(out) + H2O = ADP + D-xylose(in) + H(+) + phosphate"}
{"X":22309,"RHEA_ID":19361,"DIRECTION":"UN","MASTER_ID":19361,"ec":"2.5.1.10","compounds":"(2E)-geranyl diphosphate + isopentenyl diphosphate = (2E,6E)-farnesyl diphosphate + diphosphate"}
{"X":22310,"RHEA_ID":19362,"DIRECTION":"LR","MASTER_ID":19361,"ecocyc":"FPPSYN-RXN","reactome":"R-HSA-191303.1","compounds":"(2E)-geranyl diphosphate + isopentenyl diphosphate => (2E,6E)-farnesyl diphosphate + diphosphate"}
{"X":22311,"RHEA_ID":19363,"compounds":"(2E,6E)-farnesyl diphosphate + diphosphate => (2E)-geranyl diphosphate + isopentenyl diphosphate"}
{"X":22312,"RHEA_ID":29903,"DIRECTION":"UN","MASTER_ID":29903,"ec":"7.5.2.7","compounds":"ATP + D-ribose(out) + H2O = ADP + D-ribose(in) + H(+) + phosphate"}
{"X":22313,"RHEA_ID":19365,"DIRECTION":"UN","MASTER_ID":19365,"ec":"2.7.1.19","compounds":"ATP + D-ribulose 5-phosphate = ADP + D-ribulose 1,5-bisphosphate + H(+)"}
{"X":22314,"RHEA_ID":19366,"compounds":"ATP + D-ribulose 5-phosphate => ADP + D-ribulose 1,5-bisphosphate + H(+)"}
{"X":22315,"RHEA_ID":19367,"compounds":"ADP + D-ribulose 1,5-bisphosphate + H(+) => ATP + D-ribulose 5-phosphate"}
{"X":22316,"RHEA_ID":29907,"DIRECTION":"UN","MASTER_ID":29907,"ec":"3.1.4.46","compounds":"H2O + sn-glycero-3-phospho-(1'-rac-glycerol) = glycerol + H(+) + sn-glycerol 3-phosphate"}
{"X":22317,"RHEA_ID":19369,"DIRECTION":"UN","MASTER_ID":19369,"ec":"2.1.1.85","compounds":"L-histidyl-[protein] + S-adenosyl-L-methionine = H(+) + N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":22318,"RHEA_ID":19370,"DIRECTION":"LR","MASTER_ID":19369,"metacyc":"2.1.1.85-RXN","compounds":"L-histidyl-[protein] + S-adenosyl-L-methionine => H(+) + N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":22319,"RHEA_ID":19371,"compounds":"H(+) + N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine => L-histidyl-[protein] + S-adenosyl-L-methionine"}
{"X":22320,"RHEA_ID":29911,"compounds":"ATP + H2O + N-acetyl-D-glucosamine(in) = ADP + H(+) + N-acetyl-D-glucosamine(out) + phosphate"}
{"X":22321,"RHEA_ID":19373,"DIRECTION":"UN","MASTER_ID":19373,"ec":"1.5.1.8","compounds":"H2O + L-saccharopine + NADP(+) = 2-oxoglutarate + H(+) + L-lysine + NADPH"}
{"X":22322,"RHEA_ID":19374,"compounds":"H2O + L-saccharopine + NADP(+) => 2-oxoglutarate + H(+) + L-lysine + NADPH"}
{"X":22323,"RHEA_ID":19375,"DIRECTION":"RL","MASTER_ID":19373,"metacyc":"1.5.1.8-RXN","reactome":"R-HSA-70938.3","compounds":"2-oxoglutarate + H(+) + L-lysine + NADPH => H2O + L-saccharopine + NADP(+)"}
{"X":22324,"RHEA_ID":29915,"compounds":"L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose = alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP"}
{"X":22325,"RHEA_ID":19377,"DIRECTION":"UN","MASTER_ID":19377,"ec":"1.5.1.30","compounds":"NADP(+) + reduced riboflavin = 2 H(+) + NADPH + riboflavin"}
{"X":22326,"RHEA_ID":19377,"DIRECTION":"UN","MASTER_ID":19377,"ec":"1.5.1.41","compounds":"NADP(+) + reduced riboflavin = 2 H(+) + NADPH + riboflavin"}
{"X":22327,"RHEA_ID":19378,"compounds":"NADP(+) + reduced riboflavin => 2 H(+) + NADPH + riboflavin"}
{"X":22328,"RHEA_ID":19379,"DIRECTION":"RL","MASTER_ID":19377,"ecocyc":"RXN-12445","metacyc":"NADPH-DEHYDROGENASE-FLAVIN-RXN","compounds":"2 H(+) + NADPH + riboflavin => NADP(+) + reduced riboflavin"}
{"X":22329,"RHEA_ID":19379,"DIRECTION":"RL","MASTER_ID":19377,"ecocyc":"RXN-12445","metacyc":"RXN-12445","compounds":"2 H(+) + NADPH + riboflavin => NADP(+) + reduced riboflavin"}
{"X":22330,"RHEA_ID":19379,"DIRECTION":"RL","MASTER_ID":19377,"ecocyc":"NADPH-DEHYDROGENASE-FLAVIN-RXN","metacyc":"NADPH-DEHYDROGENASE-FLAVIN-RXN","compounds":"2 H(+) + NADPH + riboflavin => NADP(+) + reduced riboflavin"}
{"X":22331,"RHEA_ID":19379,"DIRECTION":"RL","MASTER_ID":19377,"ecocyc":"NADPH-DEHYDROGENASE-FLAVIN-RXN","metacyc":"RXN-12445","compounds":"2 H(+) + NADPH + riboflavin => NADP(+) + reduced riboflavin"}
{"X":22332,"RHEA_ID":29923,"compounds":"ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A = ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)"}
{"X":22333,"RHEA_ID":19381,"compounds":"H(+) + oxalosuccinate = 2-oxoglutarate + CO2"}
{"X":22334,"RHEA_ID":19382,"compounds":"H(+) + oxalosuccinate => 2-oxoglutarate + CO2"}
{"X":22335,"RHEA_ID":19383,"compounds":"2-oxoglutarate + CO2 => H(+) + oxalosuccinate"}
{"X":22336,"RHEA_ID":29927,"compounds":"(R)-pantothenate(in) + Na(+)(in) = (R)-pantothenate(out) + Na(+)(out)"}
{"X":22337,"RHEA_ID":19385,"DIRECTION":"UN","MASTER_ID":19385,"ec":"2.4.1.219","compounds":"UDP-alpha-D-glucose + vomilenine = H(+) + raucaffricine + UDP"}
{"X":22338,"RHEA_ID":19386,"DIRECTION":"LR","MASTER_ID":19385,"metacyc":"2.4.1.219-RXN","compounds":"UDP-alpha-D-glucose + vomilenine => H(+) + raucaffricine + UDP"}
{"X":22339,"RHEA_ID":19387,"compounds":"H(+) + raucaffricine + UDP => UDP-alpha-D-glucose + vomilenine"}
{"X":22340,"RHEA_ID":29931,"compounds":"alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP = ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)"}
{"X":22341,"RHEA_ID":19389,"DIRECTION":"UN","MASTER_ID":19389,"ec":"6.2.1.34","compounds":"ATP + CoA + trans-ferulate = (E)-feruloyl-CoA + ADP + phosphate"}
{"X":22342,"RHEA_ID":19390,"compounds":"ATP + CoA + trans-ferulate => (E)-feruloyl-CoA + ADP + phosphate"}
{"X":22343,"RHEA_ID":19391,"compounds":"(E)-feruloyl-CoA + ADP + phosphate => ATP + CoA + trans-ferulate"}
{"X":22344,"RHEA_ID":19392,"compounds":"ATP + CoA + trans-ferulate <=> (E)-feruloyl-CoA + ADP + phosphate"}
{"X":22345,"RHEA_ID":19393,"DIRECTION":"UN","MASTER_ID":19393,"ec":"2.6.1.71","compounds":"L-lysine + pyruvate = (S)-2-amino-6-oxohexanoate + L-alanine"}
{"X":22346,"RHEA_ID":19394,"compounds":"L-lysine + pyruvate => (S)-2-amino-6-oxohexanoate + L-alanine"}
{"X":22347,"RHEA_ID":19395,"compounds":"(S)-2-amino-6-oxohexanoate + L-alanine => L-lysine + pyruvate"}
{"X":22348,"RHEA_ID":29939,"compounds":"H(+)(in) + phosphate(in) = H(+)(out) + phosphate(out)"}
{"X":22349,"RHEA_ID":19397,"DIRECTION":"UN","MASTER_ID":19397,"ec":"6.3.2.5","compounds":"(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine"}
{"X":22350,"RHEA_ID":19398,"DIRECTION":"LR","MASTER_ID":19397,"ecocyc":"P-PANTOCYSLIG-RXN","metacyc":"P-PANTOCYSLIG-RXN","compounds":"(R)-4'-phosphopantothenate + CTP + L-cysteine => CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine"}
{"X":22351,"RHEA_ID":19399,"compounds":"CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine => (R)-4'-phosphopantothenate + CTP + L-cysteine"}
{"X":22352,"RHEA_ID":29943,"compounds":"2-dehydro-3-deoxy-D-gluconate(in) + H(+)(in) = 2-dehydro-3-deoxy-D-gluconate(out) + H(+)(out)"}
{"X":22353,"RHEA_ID":19401,"DIRECTION":"UN","MASTER_ID":19401,"ec":"1.1.1.244","compounds":"methanol + NAD(+) = formaldehyde + H(+) + NADH"}
{"X":22354,"RHEA_ID":19402,"DIRECTION":"LR","MASTER_ID":19401,"metacyc":"METHANOL-DEHYDROGENASE-RXN","compounds":"methanol + NAD(+) => formaldehyde + H(+) + NADH"}
{"X":22355,"RHEA_ID":19403,"compounds":"formaldehyde + H(+) + NADH => methanol + NAD(+)"}
{"X":22356,"RHEA_ID":19405,"DIRECTION":"UN","MASTER_ID":19405,"ec":"2.8.3.10","compounds":"acetyl-CoA + citrate = (3S)-citryl-CoA + acetate"}
{"X":22357,"RHEA_ID":19406,"compounds":"acetyl-CoA + citrate => (3S)-citryl-CoA + acetate"}
{"X":22358,"RHEA_ID":19407,"compounds":"(3S)-citryl-CoA + acetate => acetyl-CoA + citrate"}
{"X":22359,"RHEA_ID":29951,"compounds":"H(+)(in) + uridine(in) = H(+)(out) + uridine(out)"}
{"X":22360,"RHEA_ID":19409,"DIRECTION":"UN","MASTER_ID":19409,"ec":"1.1.1.159","compounds":"cholate + NAD(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH"}
{"X":22361,"RHEA_ID":19410,"DIRECTION":"LR","MASTER_ID":19409,"ecocyc":"7-ALPHA-HYDROXYSTEROID-DEH-RXN","metacyc":"7-ALPHA-HYDROXYSTEROID-DEH-RXN","compounds":"cholate + NAD(+) => 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH"}
{"X":22362,"RHEA_ID":19411,"compounds":"3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH => cholate + NAD(+)"}
{"X":22363,"RHEA_ID":29955,"compounds":"H(+)(in) + thymidine(in) = H(+)(out) + thymidine(out)"}
{"X":22364,"RHEA_ID":19413,"DIRECTION":"UN","MASTER_ID":19413,"ec":"6.1.1.20","compounds":"ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)"}
{"X":22365,"RHEA_ID":19414,"DIRECTION":"LR","MASTER_ID":19413,"ecocyc":"PHENYLALANINE--TRNA-LIGASE-RXN","metacyc":"PHENYLALANINE--TRNA-LIGASE-RXN","compounds":"ATP + L-phenylalanine + tRNA(Phe) => AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)"}
{"X":22366,"RHEA_ID":19415,"compounds":"AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe) => ATP + L-phenylalanine + tRNA(Phe)"}
{"X":22367,"RHEA_ID":29959,"compounds":"alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-galactose = alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP"}
{"X":22368,"RHEA_ID":19417,"DIRECTION":"UN","MASTER_ID":19417,"ec":"2.7.4.20","compounds":"[phosphate](n) + dolichyl diphosphate = [phosphate](n+1) + dolichyl phosphate"}
{"X":22369,"RHEA_ID":19418,"DIRECTION":"LR","MASTER_ID":19417,"metacyc":"2.7.4.20-RXN","compounds":"[phosphate](n) + dolichyl diphosphate => [phosphate](n+1) + dolichyl phosphate"}
{"X":22370,"RHEA_ID":19419,"compounds":"[phosphate](n+1) + dolichyl phosphate => [phosphate](n) + dolichyl diphosphate"}
{"X":22371,"RHEA_ID":19421,"DIRECTION":"UN","MASTER_ID":19421,"ec":"4.4.1.23","compounds":"(R)-2-hydroxypropyl-coenzyme M = (R)-1,2-epoxypropane + coenzyme M"}
{"X":22372,"RHEA_ID":19422,"compounds":"(R)-2-hydroxypropyl-coenzyme M => (R)-1,2-epoxypropane + coenzyme M"}
{"X":22373,"RHEA_ID":19423,"DIRECTION":"RL","MASTER_ID":19421,"metacyc":"4.2.99.19-RXN","compounds":"(R)-1,2-epoxypropane + coenzyme M => (R)-2-hydroxypropyl-coenzyme M"}
{"X":22374,"RHEA_ID":29967,"compounds":"2'-deoxyuridine(in) + H(+)(in) = 2'-deoxyuridine(out) + H(+)(out)"}
{"X":22375,"RHEA_ID":19425,"DIRECTION":"UN","MASTER_ID":19425,"ec":"1.14.13.5","compounds":"H(+) + imidazole-4-acetate + NADH + O2 = 5-hydroxyimidazole-4-acetate + H2O + NAD(+)"}
{"X":22376,"RHEA_ID":19426,"DIRECTION":"LR","MASTER_ID":19425,"metacyc":"IMIDAZOLEACETATE-4-MONOOXYGENASE-RXN","compounds":"H(+) + imidazole-4-acetate + NADH + O2 => 5-hydroxyimidazole-4-acetate + H2O + NAD(+)"}
{"X":22377,"RHEA_ID":19427,"compounds":"5-hydroxyimidazole-4-acetate + H2O + NAD(+) => H(+) + imidazole-4-acetate + NADH + O2"}
{"X":22378,"RHEA_ID":29971,"compounds":"2'-deoxyinosine(in) + H(+)(in) = 2'-deoxyinosine(out) + H(+)(out)"}
{"X":22379,"RHEA_ID":19429,"DIRECTION":"UN","MASTER_ID":19429,"ec":"2.7.11.15","compounds":"[beta-adrenergic receptor] + ATP = [beta-adrenergic receptor]-phosphate + ADP + H(+)"}
{"X":22380,"RHEA_ID":19430,"compounds":"[beta-adrenergic receptor] + ATP => [beta-adrenergic receptor]-phosphate + ADP + H(+)"}
{"X":22381,"RHEA_ID":19431,"compounds":"[beta-adrenergic receptor]-phosphate + ADP + H(+) => [beta-adrenergic receptor] + ATP"}
{"X":22382,"RHEA_ID":29975,"compounds":"2'-deoxycytidine(in) + H(+)(in) = 2'-deoxycytidine(out) + H(+)(out)"}
{"X":22383,"RHEA_ID":19433,"DIRECTION":"UN","MASTER_ID":19433,"ec":"2.7.1.12","compounds":"ATP + D-gluconate = 6-phospho-D-gluconate + ADP + H(+)"}
{"X":22384,"RHEA_ID":19434,"DIRECTION":"LR","MASTER_ID":19433,"ecocyc":"GLUCONOKIN-RXN","metacyc":"GLUCONOKIN-RXN","compounds":"ATP + D-gluconate => 6-phospho-D-gluconate + ADP + H(+)"}
{"X":22385,"RHEA_ID":19435,"compounds":"6-phospho-D-gluconate + ADP + H(+) => ATP + D-gluconate"}
{"X":22386,"RHEA_ID":29979,"compounds":"2'-deoxyadenosine(in) + H(+)(in) = 2'-deoxyadenosine(out) + H(+)(out)"}
{"X":22387,"RHEA_ID":19437,"DIRECTION":"UN","MASTER_ID":19437,"ec":"2.4.1.196","compounds":"nicotinate + UDP-alpha-D-glucose = N-(beta-D-glucosyl)nicotinate + UDP"}
{"X":22388,"RHEA_ID":19438,"compounds":"nicotinate + UDP-alpha-D-glucose => N-(beta-D-glucosyl)nicotinate + UDP"}
{"X":22389,"RHEA_ID":19439,"compounds":"N-(beta-D-glucosyl)nicotinate + UDP => nicotinate + UDP-alpha-D-glucose"}
{"X":22390,"RHEA_ID":29983,"compounds":"cytidine(in) + H(+)(in) = cytidine(out) + H(+)(out)"}
{"X":22391,"RHEA_ID":19441,"compounds":"benzene-1,2,4-triol + O2 = 3-hydroxy-cis,cis-muconate + 2 H(+)"}
{"X":22392,"RHEA_ID":19442,"DIRECTION":"LR","MASTER_ID":19441,"metacyc":"HYDROXYQUINOL-12-DIOXYGENASE-RXN","compounds":"benzene-1,2,4-triol + O2 => 3-hydroxy-cis,cis-muconate + 2 H(+)"}
{"X":22393,"RHEA_ID":19443,"compounds":"3-hydroxy-cis,cis-muconate + 2 H(+) => benzene-1,2,4-triol + O2"}
{"X":22394,"RHEA_ID":29987,"compounds":"adenosine(in) + H(+)(in) = adenosine(out) + H(+)(out)"}
{"X":22395,"RHEA_ID":19445,"DIRECTION":"UN","MASTER_ID":19445,"ec":"1.13.11.23","compounds":"2,3-dihydroxyindole + O2 = anthranilate + CO2 + H(+)"}
{"X":22396,"RHEA_ID":19446,"DIRECTION":"LR","MASTER_ID":19445,"metacyc":"23-DIHYDROXYINDOLE-23-DIOXYGENASE-RXN","compounds":"2,3-dihydroxyindole + O2 => anthranilate + CO2 + H(+)"}
{"X":22397,"RHEA_ID":19447,"compounds":"anthranilate + CO2 + H(+) => 2,3-dihydroxyindole + O2"}
{"X":22398,"RHEA_ID":29991,"compounds":"H(+)(in) + L-lyxose(in) = H(+)(out) + L-lyxose(out)"}
{"X":22399,"RHEA_ID":19453,"DIRECTION":"UN","MASTER_ID":19453,"ec":"2.6.1.2","compounds":"2-oxoglutarate + L-alanine = L-glutamate + pyruvate"}
{"X":22400,"RHEA_ID":19454,"DIRECTION":"LR","MASTER_ID":19453,"reactome":"R-HSA-507775.2","compounds":"2-oxoglutarate + L-alanine => L-glutamate + pyruvate"}
{"X":22401,"RHEA_ID":19454,"DIRECTION":"LR","MASTER_ID":19453,"reactome":"R-HSA-70523.3","compounds":"2-oxoglutarate + L-alanine => L-glutamate + pyruvate"}
{"X":22402,"RHEA_ID":19455,"DIRECTION":"RL","MASTER_ID":19453,"reactome":"R-HSA-507749.2","compounds":"L-glutamate + pyruvate => 2-oxoglutarate + L-alanine"}
{"X":22403,"RHEA_ID":19455,"DIRECTION":"RL","MASTER_ID":19453,"reactome":"R-HSA-70524.3","compounds":"L-glutamate + pyruvate => 2-oxoglutarate + L-alanine"}
{"X":22404,"RHEA_ID":29997,"compounds":"ADP + H(+) + phosphate + putrescine(in) => ATP + H2O + putrescine(out)"}
{"X":22405,"RHEA_ID":19457,"DIRECTION":"UN","MASTER_ID":19457,"ec":"1.14.13.31","compounds":"2-nitrophenol + 2 H(+) + 2 NADPH + O2 = catechol + H2O + 2 NADP(+) + nitrite"}
{"X":22406,"RHEA_ID":19458,"DIRECTION":"LR","MASTER_ID":19457,"metacyc":"2-NITROPHENOL-2-MONOOXYGENASE-RXN","compounds":"2-nitrophenol + 2 H(+) + 2 NADPH + O2 => catechol + H2O + 2 NADP(+) + nitrite"}
{"X":22407,"RHEA_ID":19459,"compounds":"catechol + H2O + 2 NADP(+) + nitrite => 2-nitrophenol + 2 H(+) + 2 NADPH + O2"}
{"X":22408,"RHEA_ID":30001,"compounds":"ADP + H(+) + phosphate + spermidine(in) => ATP + H2O + spermidine(out)"}
{"X":22409,"RHEA_ID":19461,"compounds":"3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + ATP = 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + ADP + H(+)"}
{"X":22410,"RHEA_ID":19462,"compounds":"3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + ATP => 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + ADP + H(+)"}
{"X":22411,"RHEA_ID":19463,"compounds":"3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + ADP + H(+) => 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + ATP"}
{"X":22412,"RHEA_ID":19464,"compounds":"3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + ATP <=> 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + ADP + H(+)"}
{"X":22413,"RHEA_ID":19465,"DIRECTION":"UN","MASTER_ID":19465,"ec":"1.14.12.17","compounds":"NADPH + 2 nitric oxide + 2 O2 = H(+) + NADP(+) + 2 nitrate"}
{"X":22414,"RHEA_ID":19466,"DIRECTION":"LR","MASTER_ID":19465,"ecocyc":"R621-RXN","metacyc":"R621-RXN","compounds":"NADPH + 2 nitric oxide + 2 O2 => H(+) + NADP(+) + 2 nitrate"}
{"X":22415,"RHEA_ID":19467,"compounds":"H(+) + NADP(+) + 2 nitrate => NADPH + 2 nitric oxide + 2 O2"}
{"X":22416,"RHEA_ID":19469,"DIRECTION":"UN","MASTER_ID":19469,"ec":"1.14.12.17","compounds":"NADH + 2 nitric oxide + 2 O2 = H(+) + NAD(+) + 2 nitrate"}
{"X":22417,"RHEA_ID":19470,"DIRECTION":"LR","MASTER_ID":19469,"ecocyc":"R621-RXN","metacyc":"R621-RXN","compounds":"NADH + 2 nitric oxide + 2 O2 => H(+) + NAD(+) + 2 nitrate"}
{"X":22418,"RHEA_ID":19471,"compounds":"H(+) + NAD(+) + 2 nitrate => NADH + 2 nitric oxide + 2 O2"}
{"X":22419,"RHEA_ID":19473,"DIRECTION":"UN","MASTER_ID":19473,"ec":"1.14.13.33","compounds":"4-hydroxybenzoate + H(+) + NADH + O2 = 3,4-dihydroxybenzoate + H2O + NAD(+)"}
{"X":22420,"RHEA_ID":19474,"DIRECTION":"LR","MASTER_ID":19473,"metacyc":"1.14.13.33-RXN","compounds":"4-hydroxybenzoate + H(+) + NADH + O2 => 3,4-dihydroxybenzoate + H2O + NAD(+)"}
{"X":22421,"RHEA_ID":19475,"compounds":"3,4-dihydroxybenzoate + H2O + NAD(+) => 4-hydroxybenzoate + H(+) + NADH + O2"}
{"X":22422,"RHEA_ID":30016,"DIRECTION":"LR","MASTER_ID":30015,"ecocyc":"RXN0-5126","compounds":"alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP"}
{"X":22423,"RHEA_ID":19477,"DIRECTION":"UN","MASTER_ID":19477,"ec":"1.14.13.2","compounds":"4-hydroxybenzoate + H(+) + NADPH + O2 = 3,4-dihydroxybenzoate + H2O + NADP(+)"}
{"X":22424,"RHEA_ID":19477,"DIRECTION":"UN","MASTER_ID":19477,"ec":"1.14.13.33","compounds":"4-hydroxybenzoate + H(+) + NADPH + O2 = 3,4-dihydroxybenzoate + H2O + NADP(+)"}
{"X":22425,"RHEA_ID":19478,"DIRECTION":"LR","MASTER_ID":19477,"macie":"M0131","metacyc":"1.14.13.33-RXN","compounds":"4-hydroxybenzoate + H(+) + NADPH + O2 => 3,4-dihydroxybenzoate + H2O + NADP(+)"}
{"X":22426,"RHEA_ID":19478,"DIRECTION":"LR","MASTER_ID":19477,"macie":"M0131","metacyc":"4-HYDROXYBENZOATE-3-MONOOXYGENASE-RXN","compounds":"4-hydroxybenzoate + H(+) + NADPH + O2 => 3,4-dihydroxybenzoate + H2O + NADP(+)"}
{"X":22427,"RHEA_ID":19479,"compounds":"3,4-dihydroxybenzoate + H2O + NADP(+) => 4-hydroxybenzoate + H(+) + NADPH + O2"}
{"X":22428,"RHEA_ID":30022,"compounds":"ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A <=> ADP + H(+) + lipid A-core"}
{"X":22429,"RHEA_ID":19481,"DIRECTION":"UN","MASTER_ID":19481,"ec":"2.3.1.174","compounds":"acetyl-CoA + succinyl-CoA = 3-oxoadipyl-CoA + CoA"}
{"X":22430,"RHEA_ID":19482,"compounds":"acetyl-CoA + succinyl-CoA => 3-oxoadipyl-CoA + CoA"}
{"X":22431,"RHEA_ID":19483,"DIRECTION":"RL","MASTER_ID":19481,"ecocyc":"RXN-3641","metacyc":"RXN-3641","compounds":"3-oxoadipyl-CoA + CoA => acetyl-CoA + succinyl-CoA"}
{"X":22432,"RHEA_ID":30026,"compounds":"L-alanine + pyridoxal 5'-phosphate <=> pyridoxamine 5'-phosphate + pyruvate"}
{"X":22433,"RHEA_ID":19485,"DIRECTION":"UN","MASTER_ID":19485,"ec":"2.4.1.23","metacyc":"2.4.1.23-RXN","compounds":"sphing-4-enine + UDP-alpha-D-galactose = beta-D-galactosyl-(1<->1)-sphing-4-enine + H(+) + UDP"}
{"X":22434,"RHEA_ID":19486,"compounds":"sphing-4-enine + UDP-alpha-D-galactose => beta-D-galactosyl-(1<->1)-sphing-4-enine + H(+) + UDP"}
{"X":22435,"RHEA_ID":19487,"compounds":"beta-D-galactosyl-(1<->1)-sphing-4-enine + H(+) + UDP => sphing-4-enine + UDP-alpha-D-galactose"}
{"X":22436,"RHEA_ID":19489,"compounds":"dibenzothiophene 5,5-dioxide + FMNH2 + O2 = 2'-hydroxybiphenyl-2-sulfinate + FMN-N(5)-oxide + 2 H(+)"}
{"X":22437,"RHEA_ID":19490,"DIRECTION":"LR","MASTER_ID":19489,"metacyc":"RXN-623","compounds":"dibenzothiophene 5,5-dioxide + FMNH2 + O2 => 2'-hydroxybiphenyl-2-sulfinate + FMN-N(5)-oxide + 2 H(+)"}
{"X":22438,"RHEA_ID":19491,"compounds":"2'-hydroxybiphenyl-2-sulfinate + FMN-N(5)-oxide + 2 H(+) => dibenzothiophene 5,5-dioxide + FMNH2 + O2"}
{"X":22439,"RHEA_ID":19492,"compounds":"dibenzothiophene 5,5-dioxide + FMNH2 + O2 <=> 2'-hydroxybiphenyl-2-sulfinate + FMN-N(5)-oxide + 2 H(+)"}
{"X":22440,"RHEA_ID":19493,"DIRECTION":"UN","MASTER_ID":19493,"ec":"2.4.1.20","compounds":"D-cellobiose + phosphate = alpha-D-glucose 1-phosphate + D-glucose"}
{"X":22441,"RHEA_ID":19494,"compounds":"D-cellobiose + phosphate => alpha-D-glucose 1-phosphate + D-glucose"}
{"X":22442,"RHEA_ID":19495,"compounds":"alpha-D-glucose 1-phosphate + D-glucose => D-cellobiose + phosphate"}
{"X":22443,"RHEA_ID":40015,"compounds":"(+)-copalyl diphosphate + H2O = 13-epi-manool + diphosphate"}
{"X":22444,"RHEA_ID":19497,"DIRECTION":"UN","MASTER_ID":19497,"ec":"4.1.1.11","compounds":"H(+) + L-aspartate = beta-alanine + CO2"}
{"X":22445,"RHEA_ID":19498,"DIRECTION":"LR","MASTER_ID":19497,"ecocyc":"ASPDECARBOX-RXN","metacyc":"ASPDECARBOX-RXN","reactome":"R-HSA-6787757.2","compounds":"H(+) + L-aspartate => beta-alanine + CO2"}
{"X":22446,"RHEA_ID":19499,"compounds":"beta-alanine + CO2 => H(+) + L-aspartate"}
{"X":22447,"RHEA_ID":19501,"DIRECTION":"UN","MASTER_ID":19501,"ec":"3.5.3.7","compounds":"4-guanidinobutanoate + H2O = 4-aminobutanoate + urea"}
{"X":22448,"RHEA_ID":19502,"DIRECTION":"LR","MASTER_ID":19501,"metacyc":"GUANIDINOBUTYRASE-RXN","compounds":"4-guanidinobutanoate + H2O => 4-aminobutanoate + urea"}
{"X":22449,"RHEA_ID":19503,"compounds":"4-aminobutanoate + urea => 4-guanidinobutanoate + H2O"}
{"X":22450,"RHEA_ID":30046,"compounds":"fumarate + L-aspartate <=> iminosuccinate + succinate"}
{"X":22451,"RHEA_ID":19505,"DIRECTION":"UN","MASTER_ID":19505,"ec":"2.4.2.34","compounds":"indole-3-acetyl-1D-myo-inositol + UDP-beta-L-arabinopyranose = (indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + H(+) + UDP"}
{"X":22452,"RHEA_ID":19506,"DIRECTION":"LR","MASTER_ID":19505,"metacyc":"2.4.2.34-RXN","compounds":"indole-3-acetyl-1D-myo-inositol + UDP-beta-L-arabinopyranose => (indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + H(+) + UDP"}
{"X":22453,"RHEA_ID":19507,"compounds":"(indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + H(+) + UDP => indole-3-acetyl-1D-myo-inositol + UDP-beta-L-arabinopyranose"}
{"X":22454,"RHEA_ID":19509,"DIRECTION":"UN","MASTER_ID":19509,"ec":"1.5.1.33","compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = 2 H(+) + L-erythro-biopterin + 2 NADPH"}
{"X":22455,"RHEA_ID":19510,"compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) => 2 H(+) + L-erythro-biopterin + 2 NADPH"}
{"X":22456,"RHEA_ID":19511,"DIRECTION":"RL","MASTER_ID":19509,"macie":"M0237","compounds":"2 H(+) + L-erythro-biopterin + 2 NADPH => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+)"}
{"X":22457,"RHEA_ID":19513,"DIRECTION":"UN","MASTER_ID":19513,"ec":"2.1.3.3","compounds":"carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate"}
{"X":22458,"RHEA_ID":19514,"DIRECTION":"LR","MASTER_ID":19513,"macie":"M0012","reactome":"R-HSA-70560.3","compounds":"carbamoyl phosphate + L-ornithine => H(+) + L-citrulline + phosphate"}
{"X":22459,"RHEA_ID":19515,"compounds":"H(+) + L-citrulline + phosphate => carbamoyl phosphate + L-ornithine"}
{"X":22460,"RHEA_ID":40035,"DIRECTION":"UN","MASTER_ID":40035,"ec":"6.3.2.41","compounds":"ATP + L-glutamate + N-acetyl-L-aspartate = ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate + phosphate"}
{"X":22461,"RHEA_ID":19517,"DIRECTION":"UN","MASTER_ID":19517,"ec":"3.5.1.56","compounds":"H2O + N,N-dimethylformamide = dimethylamine + formate"}
{"X":22462,"RHEA_ID":19518,"compounds":"H2O + N,N-dimethylformamide => dimethylamine + formate"}
{"X":22463,"RHEA_ID":19519,"compounds":"dimethylamine + formate => H2O + N,N-dimethylformamide"}
{"X":22464,"RHEA_ID":19521,"DIRECTION":"UN","MASTER_ID":19521,"ec":"2.3.1.8","compounds":"acetyl-CoA + phosphate = acetyl phosphate + CoA"}
{"X":22465,"RHEA_ID":19522,"compounds":"acetyl-CoA + phosphate => acetyl phosphate + CoA"}
{"X":22466,"RHEA_ID":19523,"compounds":"acetyl phosphate + CoA => acetyl-CoA + phosphate"}
{"X":22467,"RHEA_ID":30066,"compounds":"2-demethylmenaquinol-8 + S-adenosyl-L-methionine <=> H(+) + menaquinol-8 + S-adenosyl-L-homocysteine"}
{"X":22468,"RHEA_ID":19525,"DIRECTION":"UN","MASTER_ID":19525,"ec":"4.2.3.n2","compounds":"(2E,6E)-farnesyl diphosphate = (1S,8aR)-delta-cadinene + diphosphate"}
{"X":22469,"RHEA_ID":19525,"DIRECTION":"UN","MASTER_ID":19525,"ec":"4.2.3.13","compounds":"(2E,6E)-farnesyl diphosphate = (1S,8aR)-delta-cadinene + diphosphate"}
{"X":22470,"RHEA_ID":19526,"DIRECTION":"LR","MASTER_ID":19525,"metacyc":"4.6.1.11-RXN","compounds":"(2E,6E)-farnesyl diphosphate => (1S,8aR)-delta-cadinene + diphosphate"}
{"X":22471,"RHEA_ID":19527,"compounds":"(1S,8aR)-delta-cadinene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":22472,"RHEA_ID":30071,"compounds":"acetyl-CoA + butanoate = acetate + butanoyl-CoA"}
{"X":22473,"RHEA_ID":19529,"DIRECTION":"UN","MASTER_ID":19529,"ec":"2.4.1.106","compounds":"isovitexin + UDP-alpha-D-glucose = H(+) + isovitexin 2''-O-beta-D-glucoside + UDP"}
{"X":22474,"RHEA_ID":19530,"DIRECTION":"LR","MASTER_ID":19529,"metacyc":"ISOVITEXIN-BETA-GLUCOSYLTRANSFERASE-RXN","compounds":"isovitexin + UDP-alpha-D-glucose => H(+) + isovitexin 2''-O-beta-D-glucoside + UDP"}
{"X":22475,"RHEA_ID":19531,"compounds":"H(+) + isovitexin 2''-O-beta-D-glucoside + UDP => isovitexin + UDP-alpha-D-glucose"}
{"X":22476,"RHEA_ID":30075,"DIRECTION":"UN","MASTER_ID":30075,"ec":"3.2.2.10","compounds":"CMP + H2O = cytosine + D-ribose 5-phosphate"}
{"X":22477,"RHEA_ID":19533,"DIRECTION":"UN","MASTER_ID":19533,"ec":"3.5.3.23","compounds":"2 H(+) + 2 H2O + N(2)-succinyl-L-arginine = CO2 + N(2)-succinyl-L-ornithine + 2 NH4(+)"}
{"X":22478,"RHEA_ID":19534,"DIRECTION":"LR","MASTER_ID":19533,"ecocyc":"SUCCARGDIHYDRO-RXN","metacyc":"SUCCARGDIHYDRO-RXN","compounds":"2 H(+) + 2 H2O + N(2)-succinyl-L-arginine => CO2 + N(2)-succinyl-L-ornithine + 2 NH4(+)"}
{"X":22479,"RHEA_ID":19535,"compounds":"CO2 + N(2)-succinyl-L-ornithine + 2 NH4(+) => 2 H(+) + 2 H2O + N(2)-succinyl-L-arginine"}
{"X":22480,"RHEA_ID":30079,"DIRECTION":"UN","MASTER_ID":30079,"ec":"6.2.1.48","compounds":"ATP + CoA + crotonobetaine = AMP + crotonobetainyl-CoA + diphosphate"}
{"X":22481,"RHEA_ID":19537,"DIRECTION":"UN","MASTER_ID":19537,"ec":"3.1.3.22","compounds":"D-mannitol 1-phosphate + H2O = D-mannitol + phosphate"}
{"X":22482,"RHEA_ID":19538,"DIRECTION":"LR","MASTER_ID":19537,"metacyc":"MANNITOL-1-PHOSPHATASE-RXN","compounds":"D-mannitol 1-phosphate + H2O => D-mannitol + phosphate"}
{"X":22483,"RHEA_ID":19539,"compounds":"D-mannitol + phosphate => D-mannitol 1-phosphate + H2O"}
{"X":22484,"RHEA_ID":30083,"compounds":"4 Cu(+) + 4 H(+) + O2 = 4 Cu(2+) + 2 H2O"}
{"X":22485,"RHEA_ID":19541,"DIRECTION":"UN","MASTER_ID":19541,"ec":"1.2.1.41","compounds":"L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH"}
{"X":22486,"RHEA_ID":19542,"compounds":"L-glutamate 5-semialdehyde + NADP(+) + phosphate => H(+) + L-glutamyl 5-phosphate + NADPH"}
{"X":22487,"RHEA_ID":19543,"DIRECTION":"RL","MASTER_ID":19541,"ecocyc":"GLUTSEMIALDEHYDROG-RXN","metacyc":"GLUTSEMIALDEHYDROG-RXN","compounds":"H(+) + L-glutamyl 5-phosphate + NADPH => L-glutamate 5-semialdehyde + NADP(+) + phosphate"}
{"X":22488,"RHEA_ID":30087,"compounds":"(S)-2-hydroxyglutarate + FAD + H(+) = 2-oxoglutarate + FADH2"}
{"X":22489,"RHEA_ID":19545,"DIRECTION":"UN","MASTER_ID":19545,"ec":"3.1.4.38","compounds":"H2O + sn-glycerol 3-phosphocholine = glycerol + H(+) + phosphocholine"}
{"X":22490,"RHEA_ID":19546,"DIRECTION":"LR","MASTER_ID":19545,"metacyc":"3.1.4.38-RXN","compounds":"H2O + sn-glycerol 3-phosphocholine => glycerol + H(+) + phosphocholine"}
{"X":22491,"RHEA_ID":19547,"compounds":"glycerol + H(+) + phosphocholine => H2O + sn-glycerol 3-phosphocholine"}
{"X":22492,"RHEA_ID":30091,"compounds":"a ubiquinone + D-alanine + H2O = a ubiquinol + NH4(+) + pyruvate"}
{"X":22493,"RHEA_ID":19549,"DIRECTION":"UN","MASTER_ID":19549,"ec":"3.1.1.40","compounds":"H2O + orsellinate depside = H(+) + 2 orsellinate"}
{"X":22494,"RHEA_ID":19550,"DIRECTION":"LR","MASTER_ID":19549,"metacyc":"ORSELLINATE-DEPSIDE-HYDROLASE-RXN","compounds":"H2O + orsellinate depside => H(+) + 2 orsellinate"}
{"X":22495,"RHEA_ID":19551,"compounds":"H(+) + 2 orsellinate => H2O + orsellinate depside"}
{"X":22496,"RHEA_ID":30095,"DIRECTION":"UN","MASTER_ID":30095,"ec":"1.1.5.4","compounds":"(S)-malate + a menaquinone = a menaquinol + oxaloacetate"}
{"X":22497,"RHEA_ID":19553,"DIRECTION":"UN","MASTER_ID":19553,"ec":"4.1.99.1","compounds":"H2O + L-tryptophan = indole + NH4(+) + pyruvate"}
{"X":22498,"RHEA_ID":19554,"DIRECTION":"LR","MASTER_ID":19553,"ecocyc":"TRYPTOPHAN-RXN","metacyc":"TRYPTOPHAN-RXN","compounds":"H2O + L-tryptophan => indole + NH4(+) + pyruvate"}
{"X":22499,"RHEA_ID":19555,"compounds":"indole + NH4(+) + pyruvate => H2O + L-tryptophan"}
{"X":22500,"RHEA_ID":30099,"DIRECTION":"UN","MASTER_ID":30099,"ec":"2.5.1.74","compounds":"1,4-dihydroxy-2-naphthoate + all-trans-octaprenyl diphosphate + H(+) = 2-demethylmenaquinol-8 + CO2 + diphosphate"}
{"X":22501,"RHEA_ID":19557,"DIRECTION":"UN","MASTER_ID":19557,"ec":"1.14.99.24","compounds":"AH2 + O2 + pregna-4,9(11)-diene-3,20-dione = 9,11alpha-epoxypregn-4-ene-3,20-dione + A + H2O"}
{"X":22502,"RHEA_ID":19558,"DIRECTION":"LR","MASTER_ID":19557,"metacyc":"STEROID-9-ALPHA-MONOOXYGENASE-RXN","compounds":"AH2 + O2 + pregna-4,9(11)-diene-3,20-dione => 9,11alpha-epoxypregn-4-ene-3,20-dione + A + H2O"}
{"X":22503,"RHEA_ID":19559,"compounds":"9,11alpha-epoxypregn-4-ene-3,20-dione + A + H2O => AH2 + O2 + pregna-4,9(11)-diene-3,20-dione"}
{"X":22504,"RHEA_ID":30103,"compounds":"2,5-didehydro-D-gluconate + H(+) + NADH = 5-dehydro-D-gluconate + NAD(+)"}
{"X":22505,"RHEA_ID":19561,"DIRECTION":"UN","MASTER_ID":19561,"ec":"1.14.13.54","compounds":"androst-4-ene-3,17-dione + H(+) + NADPH + O2 = H2O + NADP(+) + testololactone"}
{"X":22506,"RHEA_ID":19562,"DIRECTION":"LR","MASTER_ID":19561,"metacyc":"RXN-781","compounds":"androst-4-ene-3,17-dione + H(+) + NADPH + O2 => H2O + NADP(+) + testololactone"}
{"X":22507,"RHEA_ID":19563,"compounds":"H2O + NADP(+) + testololactone => androst-4-ene-3,17-dione + H(+) + NADPH + O2"}
{"X":22508,"RHEA_ID":30107,"compounds":"D-serine + NADP(+) = 2-aminomalonate semialdehyde + H(+) + NADPH"}
{"X":22509,"RHEA_ID":19565,"DIRECTION":"UN","MASTER_ID":19565,"ec":"4.2.3.11","compounds":"(2E)-geranyl diphosphate + H2O = diphosphate + sabinene hydrate"}
{"X":22510,"RHEA_ID":19566,"DIRECTION":"LR","MASTER_ID":19565,"metacyc":"4.2.3.11-RXN","compounds":"(2E)-geranyl diphosphate + H2O => diphosphate + sabinene hydrate"}
{"X":22511,"RHEA_ID":19567,"compounds":"diphosphate + sabinene hydrate => (2E)-geranyl diphosphate + H2O"}
{"X":22512,"RHEA_ID":30111,"DIRECTION":"UN","MASTER_ID":30111,"ec":"3.1.1.108","compounds":"Fe(III)-enterobactin + H(+) + 3 H2O = Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + 2 N-(2,3-dihydroxybenzoyl)-L-serine"}
{"X":22513,"RHEA_ID":19569,"DIRECTION":"UN","MASTER_ID":19569,"ec":"2.1.1.61","compounds":"5-aminomethyl-2-thiouridine(34) in tRNA + S-adenosyl-L-methionine = 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":22514,"RHEA_ID":19570,"DIRECTION":"LR","MASTER_ID":19569,"ecocyc":"RXN0-5144","metacyc":"RXN0-5144","compounds":"5-aminomethyl-2-thiouridine(34) in tRNA + S-adenosyl-L-methionine => 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":22515,"RHEA_ID":19571,"compounds":"5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine => 5-aminomethyl-2-thiouridine(34) in tRNA + S-adenosyl-L-methionine"}
{"X":22516,"RHEA_ID":30115,"compounds":"decanoyl-[ACP] + H2O = decanoate + H(+) + holo-[ACP]"}
{"X":22517,"RHEA_ID":19573,"DIRECTION":"UN","MASTER_ID":19573,"ec":"2.7.4.1","compounds":"[phosphate](n) + ATP = [phosphate](n+1) + ADP"}
{"X":22518,"RHEA_ID":19574,"compounds":"[phosphate](n) + ATP => [phosphate](n+1) + ADP"}
{"X":22519,"RHEA_ID":19575,"compounds":"[phosphate](n+1) + ADP => [phosphate](n) + ATP"}
{"X":22520,"RHEA_ID":30119,"DIRECTION":"UN","MASTER_ID":30119,"ec":"3.1.2.21","compounds":"dodecanoyl-[ACP] + H2O = dodecanoate + H(+) + holo-[ACP]"}
{"X":22521,"RHEA_ID":19577,"DIRECTION":"UN","MASTER_ID":19577,"ec":"2.4.1.81","compounds":"luteolin + UDP-alpha-D-glucose = H(+) + luteolin 7-O-beta-D-glucoside + UDP"}
{"X":22522,"RHEA_ID":19578,"DIRECTION":"LR","MASTER_ID":19577,"metacyc":"FLAVONE-7-O-BETA-GLUCOSYLTRANSFERASE-RXN","compounds":"luteolin + UDP-alpha-D-glucose => H(+) + luteolin 7-O-beta-D-glucoside + UDP"}
{"X":22523,"RHEA_ID":19579,"compounds":"H(+) + luteolin 7-O-beta-D-glucoside + UDP => luteolin + UDP-alpha-D-glucose"}
{"X":22524,"RHEA_ID":30123,"DIRECTION":"UN","MASTER_ID":30123,"ec":"3.1.2.14","compounds":"H2O + tetradecanoyl-[ACP] = H(+) + holo-[ACP] + tetradecanoate"}
{"X":22525,"RHEA_ID":19581,"DIRECTION":"UN","MASTER_ID":19581,"ec":"2.5.1.24","compounds":"N(6)-dimethylallyladenine + S-adenosyl-L-methionine = discadenine + H(+) + S-methyl-5'-thioadenosine"}
{"X":22526,"RHEA_ID":19582,"DIRECTION":"LR","MASTER_ID":19581,"metacyc":"DISCADENINE-SYNTHASE-RXN","compounds":"N(6)-dimethylallyladenine + S-adenosyl-L-methionine => discadenine + H(+) + S-methyl-5'-thioadenosine"}
{"X":22527,"RHEA_ID":19583,"compounds":"discadenine + H(+) + S-methyl-5'-thioadenosine => N(6)-dimethylallyladenine + S-adenosyl-L-methionine"}
{"X":22528,"RHEA_ID":30131,"DIRECTION":"UN","MASTER_ID":30131,"ec":"3.1.2.14","compounds":"H2O + octanoyl-[ACP] = H(+) + holo-[ACP] + octanoate"}
{"X":22529,"RHEA_ID":19585,"DIRECTION":"UN","MASTER_ID":19585,"ec":"1.1.1.52","compounds":"lithocholate + NAD(+) = 3-oxo-5beta-cholan-24-oate + H(+) + NADH"}
{"X":22530,"RHEA_ID":19586,"compounds":"lithocholate + NAD(+) => 3-oxo-5beta-cholan-24-oate + H(+) + NADH"}
{"X":22531,"RHEA_ID":19587,"compounds":"3-oxo-5beta-cholan-24-oate + H(+) + NADH => lithocholate + NAD(+)"}
{"X":22532,"RHEA_ID":30135,"compounds":"dodecanoyl-CoA + H2O = CoA + dodecanoate + H(+)"}
{"X":22533,"RHEA_ID":19597,"DIRECTION":"UN","MASTER_ID":19597,"ec":"3.5.3.6","compounds":"H2O + L-arginine = L-citrulline + NH4(+)"}
{"X":22534,"RHEA_ID":19598,"compounds":"H2O + L-arginine => L-citrulline + NH4(+)"}
{"X":22535,"RHEA_ID":19599,"compounds":"L-citrulline + NH4(+) => H2O + L-arginine"}
{"X":22536,"RHEA_ID":30139,"compounds":"H2O + octadecanoyl-CoA = CoA + H(+) + octadecanoate"}
{"X":22537,"RHEA_ID":19601,"DIRECTION":"UN","MASTER_ID":19601,"ec":"1.14.13.6","compounds":"H(+) + NADH + O2 + orcinol = 2,3,5-trihydroxytoluene + H2O + NAD(+)"}
{"X":22538,"RHEA_ID":19602,"DIRECTION":"LR","MASTER_ID":19601,"metacyc":"ORCINOL-2-MONOOXYGENASE-RXN","compounds":"H(+) + NADH + O2 + orcinol => 2,3,5-trihydroxytoluene + H2O + NAD(+)"}
{"X":22539,"RHEA_ID":19603,"compounds":"2,3,5-trihydroxytoluene + H2O + NAD(+) => H(+) + NADH + O2 + orcinol"}
{"X":22540,"RHEA_ID":30143,"compounds":"H2O + octanoyl-CoA = CoA + H(+) + octanoate"}
{"X":22541,"RHEA_ID":19605,"DIRECTION":"UN","MASTER_ID":19605,"ec":"3.1.1.14","compounds":"a chlorophyll + H2O = a chlorophyllide + H(+) + phytol"}
{"X":22542,"RHEA_ID":19606,"DIRECTION":"LR","MASTER_ID":19605,"metacyc":"CHLOROPHYLLASE-RXN","compounds":"a chlorophyll + H2O => a chlorophyllide + H(+) + phytol"}
{"X":22543,"RHEA_ID":19607,"compounds":"a chlorophyllide + H(+) + phytol => a chlorophyll + H2O"}
{"X":22544,"RHEA_ID":19608,"compounds":"a chlorophyll + H2O <=> a chlorophyllide + H(+) + phytol"}
{"X":22545,"RHEA_ID":19609,"DIRECTION":"UN","MASTER_ID":19609,"ec":"2.1.1.182","compounds":"adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine"}
{"X":22546,"RHEA_ID":19610,"DIRECTION":"LR","MASTER_ID":19609,"ecocyc":"RXN-11633","metacyc":"RXN-11633","compounds":"adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine => 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine"}
{"X":22547,"RHEA_ID":19611,"compounds":"4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine => adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine"}
{"X":22548,"RHEA_ID":19612,"compounds":"adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine <=> 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine"}
{"X":22549,"RHEA_ID":19613,"DIRECTION":"UN","MASTER_ID":19613,"ec":"2.1.1.96","compounds":"dimethyl sulfide + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + trimethylsulfonium"}
{"X":22550,"RHEA_ID":19614,"DIRECTION":"LR","MASTER_ID":19613,"metacyc":"THIOETHER-S-METHYLTRANSFERASE-RXN","compounds":"dimethyl sulfide + S-adenosyl-L-methionine => S-adenosyl-L-homocysteine + trimethylsulfonium"}
{"X":22551,"RHEA_ID":19615,"compounds":"S-adenosyl-L-homocysteine + trimethylsulfonium => dimethyl sulfide + S-adenosyl-L-methionine"}
{"X":22552,"RHEA_ID":40128,"compounds":"an omega-oxo fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => a dicarboxylate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":22553,"RHEA_ID":19617,"DIRECTION":"UN","MASTER_ID":19617,"ec":"2.1.1.57","compounds":"a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":22554,"RHEA_ID":19618,"DIRECTION":"LR","MASTER_ID":19617,"metacyc":"2.1.1.57-RXN","compounds":"a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":22555,"RHEA_ID":19619,"compounds":"a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + S-adenosyl-L-methionine"}
{"X":22556,"RHEA_ID":30158,"compounds":"FADH2 + 2 Fe(3+) <=> FAD + 2 Fe(2+) + 3 H(+)"}
{"X":22557,"RHEA_ID":19621,"DIRECTION":"UN","MASTER_ID":19621,"ec":"3.1.4.16","compounds":"a nucleoside 2',3'-cyclic phosphate + H2O = a nucleoside 3'-phosphate + H(+)"}
{"X":22558,"RHEA_ID":19622,"DIRECTION":"LR","MASTER_ID":19621,"ecocyc":"CYCPHOSDIESTER-RXN","metacyc":"CYCPHOSDIESTER-RXN","compounds":"a nucleoside 2',3'-cyclic phosphate + H2O => a nucleoside 3'-phosphate + H(+)"}
{"X":22559,"RHEA_ID":19623,"compounds":"a nucleoside 3'-phosphate + H(+) => a nucleoside 2',3'-cyclic phosphate + H2O"}
{"X":22560,"RHEA_ID":19625,"DIRECTION":"UN","MASTER_ID":19625,"ec":"4.1.2.5","compounds":"L-threonine = acetaldehyde + glycine"}
{"X":22561,"RHEA_ID":19625,"DIRECTION":"UN","MASTER_ID":19625,"ec":"4.1.2.48","compounds":"L-threonine = acetaldehyde + glycine"}
{"X":22562,"RHEA_ID":19626,"DIRECTION":"LR","MASTER_ID":19625,"ecocyc":"THREONINE-ALDOLASE-RXN","metacyc":"THREONINE-ALDOLASE-RXN","compounds":"L-threonine => acetaldehyde + glycine"}
{"X":22563,"RHEA_ID":19627,"compounds":"acetaldehyde + glycine => L-threonine"}
{"X":22564,"RHEA_ID":19629,"DIRECTION":"UN","MASTER_ID":19629,"ec":"1.1.1.42","compounds":"isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH"}
{"X":22565,"RHEA_ID":19630,"DIRECTION":"LR","MASTER_ID":19629,"macie":"M0007","compounds":"isocitrate + NADP(+) => 2-oxoglutarate + CO2 + NADPH"}
{"X":22566,"RHEA_ID":19631,"compounds":"2-oxoglutarate + CO2 + NADPH => isocitrate + NADP(+)"}
{"X":22567,"RHEA_ID":30171,"compounds":"hexadecanoyl-[ACP] + sn-glycerol 3-phosphate = 1-hexadecanoyl-sn-glycero-3-phosphate + holo-[ACP]"}
{"X":22568,"RHEA_ID":19633,"DIRECTION":"UN","MASTER_ID":19633,"ec":"1.4.1.11","compounds":"(3S,5S)-3,5-diaminohexanoate + H2O + NAD(+) = (5S)-5-amino-3-oxo-hexanoate + H(+) + NADH + NH4(+)"}
{"X":22569,"RHEA_ID":19634,"DIRECTION":"LR","MASTER_ID":19633,"metacyc":"1.4.1.11-RXN","compounds":"(3S,5S)-3,5-diaminohexanoate + H2O + NAD(+) => (5S)-5-amino-3-oxo-hexanoate + H(+) + NADH + NH4(+)"}
{"X":22570,"RHEA_ID":19635,"compounds":"(5S)-5-amino-3-oxo-hexanoate + H(+) + NADH + NH4(+) => (3S,5S)-3,5-diaminohexanoate + H2O + NAD(+)"}
{"X":22571,"RHEA_ID":30175,"DIRECTION":"UN","MASTER_ID":30175,"ec":"1.3.5.5","compounds":"15-cis-phytoene + 2 plastoquinone-9 = 9,9',15-tri-cis-zeta-carotene + 2 plastoquinol-9"}
{"X":22572,"RHEA_ID":19637,"DIRECTION":"UN","MASTER_ID":19637,"ec":"1.5.1.19","compounds":"D-nopaline + H2O + NADP(+) = 2-oxoglutarate + H(+) + L-arginine + NADPH"}
{"X":22573,"RHEA_ID":19638,"compounds":"D-nopaline + H2O + NADP(+) => 2-oxoglutarate + H(+) + L-arginine + NADPH"}
{"X":22574,"RHEA_ID":19639,"DIRECTION":"RL","MASTER_ID":19637,"metacyc":"1.5.1.19-RXN","compounds":"2-oxoglutarate + H(+) + L-arginine + NADPH => D-nopaline + H2O + NADP(+)"}
{"X":22575,"RHEA_ID":30179,"DIRECTION":"UN","MASTER_ID":30179,"ec":"1.2.7.10","compounds":"oxalate + oxidized 2[4Fe-4S]-[ferredoxin] = 2 CO2 + reduced 2[4Fe-4S]-[ferredoxin]"}
{"X":22576,"RHEA_ID":19641,"DIRECTION":"UN","MASTER_ID":19641,"ec":"6.2.1.12","compounds":"4-coumarate + ATP + CoA = 4-coumaroyl-CoA + AMP + diphosphate"}
{"X":22577,"RHEA_ID":19642,"DIRECTION":"LR","MASTER_ID":19641,"metacyc":"4-COUMARATE--COA-LIGASE-RXN","compounds":"4-coumarate + ATP + CoA => 4-coumaroyl-CoA + AMP + diphosphate"}
{"X":22578,"RHEA_ID":19643,"compounds":"4-coumaroyl-CoA + AMP + diphosphate => 4-coumarate + ATP + CoA"}
{"X":22579,"RHEA_ID":30183,"DIRECTION":"UN","MASTER_ID":30183,"ec":"1.1.1.414","compounds":"L-galactonate + NAD(+) = H(+) + keto-D-tagaturonate + NADH"}
{"X":22580,"RHEA_ID":19645,"DIRECTION":"UN","MASTER_ID":19645,"ec":"1.1.1.122","compounds":"a D-threo-aldose + NAD(+) = a D-threo-aldono-1,5-lactone + H(+) + NADH"}
{"X":22581,"RHEA_ID":19646,"compounds":"a D-threo-aldose + NAD(+) => a D-threo-aldono-1,5-lactone + H(+) + NADH"}
{"X":22582,"RHEA_ID":19647,"compounds":"a D-threo-aldono-1,5-lactone + H(+) + NADH => a D-threo-aldose + NAD(+)"}
{"X":22583,"RHEA_ID":19649,"DIRECTION":"UN","MASTER_ID":19649,"ec":"6.1.1.12","compounds":"ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)"}
{"X":22584,"RHEA_ID":19650,"DIRECTION":"LR","MASTER_ID":19649,"ecocyc":"ASPARTATE--TRNA-LIGASE-RXN","metacyc":"ASPARTATE--TRNA-LIGASE-RXN","compounds":"ATP + L-aspartate + tRNA(Asp) => AMP + diphosphate + L-aspartyl-tRNA(Asp)"}
{"X":22585,"RHEA_ID":19651,"compounds":"AMP + diphosphate + L-aspartyl-tRNA(Asp) => ATP + L-aspartate + tRNA(Asp)"}
{"X":22586,"RHEA_ID":30191,"compounds":"15-cis-phytoene + plastoquinone-9 = 15,9'-di-cis-phytofluene + plastoquinol-9"}
{"X":22587,"RHEA_ID":19653,"DIRECTION":"UN","MASTER_ID":19653,"ec":"1.17.1.1","compounds":"CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NAD(+) = CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH"}
{"X":22588,"RHEA_ID":19654,"compounds":"CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NAD(+) => CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH"}
{"X":22589,"RHEA_ID":19655,"DIRECTION":"RL","MASTER_ID":19653,"metacyc":"1.17.1.1-RXN","compounds":"CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH => CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NAD(+)"}
{"X":22590,"RHEA_ID":30195,"compounds":"15,9'-di-cis-phytofluene + plastoquinone-9 = 9,9',15-tri-cis-zeta-carotene + plastoquinol-9"}
{"X":22591,"RHEA_ID":19657,"DIRECTION":"UN","MASTER_ID":19657,"ec":"1.17.1.1","compounds":"CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NADP(+) = CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH"}
{"X":22592,"RHEA_ID":19658,"compounds":"CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NADP(+) => CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH"}
{"X":22593,"RHEA_ID":19659,"DIRECTION":"RL","MASTER_ID":19657,"metacyc":"1.17.1.1-RXN","compounds":"CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH => CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NADP(+)"}
{"X":22594,"RHEA_ID":30199,"DIRECTION":"UN","MASTER_ID":30199,"ec":"1.3.7.8","compounds":"2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate = 2 ATP + benzoyl-CoA + 2 H2O + reduced 2[4Fe-4S]-[ferredoxin]"}
{"X":22595,"RHEA_ID":19661,"DIRECTION":"UN","MASTER_ID":19661,"ec":"1.1.1.17","compounds":"D-mannitol 1-phosphate + NAD(+) = beta-D-fructose 6-phosphate + H(+) + NADH"}
{"X":22596,"RHEA_ID":19662,"compounds":"D-mannitol 1-phosphate + NAD(+) => beta-D-fructose 6-phosphate + H(+) + NADH"}
{"X":22597,"RHEA_ID":19663,"compounds":"beta-D-fructose 6-phosphate + H(+) + NADH => D-mannitol 1-phosphate + NAD(+)"}
{"X":22598,"RHEA_ID":30203,"DIRECTION":"UN","MASTER_ID":30203,"ec":"3.6.1.41","compounds":"H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate = 2 GDP + 2 H(+)"}
{"X":22599,"RHEA_ID":19665,"DIRECTION":"UN","MASTER_ID":19665,"ec":"1.3.1.62","compounds":"6-carboxyhexanoyl-CoA + NAD(+) = 6-carboxyhex-2-enoyl-CoA + H(+) + NADH"}
{"X":22600,"RHEA_ID":19666,"DIRECTION":"LR","MASTER_ID":19665,"metacyc":"1.3.1.62-RXN","compounds":"6-carboxyhexanoyl-CoA + NAD(+) => 6-carboxyhex-2-enoyl-CoA + H(+) + NADH"}
{"X":22601,"RHEA_ID":19667,"compounds":"6-carboxyhex-2-enoyl-CoA + H(+) + NADH => 6-carboxyhexanoyl-CoA + NAD(+)"}
{"X":22602,"RHEA_ID":30207,"DIRECTION":"UN","MASTER_ID":30207,"ec":"1.4.9.1","compounds":"H2O + methylamine + 2 oxidized [amicyanin] = formaldehyde + 2 H(+) + NH4(+) + 2 reduced [amicyanin]"}
{"X":22603,"RHEA_ID":19669,"DIRECTION":"UN","MASTER_ID":19669,"ec":"3.6.5.4","compounds":"GTP + H2O = GDP + H(+) + phosphate"}
{"X":22604,"RHEA_ID":19669,"DIRECTION":"UN","MASTER_ID":19669,"ec":"3.6.5.6","compounds":"GTP + H2O = GDP + H(+) + phosphate"}
{"X":22605,"RHEA_ID":19669,"DIRECTION":"UN","MASTER_ID":19669,"ec":"3.6.5.1","compounds":"GTP + H2O = GDP + H(+) + phosphate"}
{"X":22606,"RHEA_ID":19669,"DIRECTION":"UN","MASTER_ID":19669,"ec":"3.6.5.2","compounds":"GTP + H2O = GDP + H(+) + phosphate"}
{"X":22607,"RHEA_ID":19669,"DIRECTION":"UN","MASTER_ID":19669,"ec":"3.6.5.3","compounds":"GTP + H2O = GDP + H(+) + phosphate"}
{"X":22608,"RHEA_ID":19669,"DIRECTION":"UN","MASTER_ID":19669,"ec":"3.6.5.5","compounds":"GTP + H2O = GDP + H(+) + phosphate"}
{"X":22609,"RHEA_ID":19669,"DIRECTION":"UN","MASTER_ID":19669,"ec":"3.6.5.n1","compounds":"GTP + H2O = GDP + H(+) + phosphate"}
{"X":22610,"RHEA_ID":19670,"DIRECTION":"LR","MASTER_ID":19669,"ecocyc":"3.6.5.1-RXN","metacyc":"3.6.5.1-RXN","compounds":"GTP + H2O => GDP + H(+) + phosphate"}
{"X":22611,"RHEA_ID":19670,"DIRECTION":"LR","MASTER_ID":19669,"ecocyc":"3.6.5.1-RXN","metacyc":"RXN0-5462","compounds":"GTP + H2O => GDP + H(+) + phosphate"}
{"X":22612,"RHEA_ID":19670,"DIRECTION":"LR","MASTER_ID":19669,"ecocyc":"RXN0-5462","metacyc":"3.6.5.1-RXN","compounds":"GTP + H2O => GDP + H(+) + phosphate"}
{"X":22613,"RHEA_ID":19670,"DIRECTION":"LR","MASTER_ID":19669,"ecocyc":"RXN0-5462","metacyc":"RXN0-5462","compounds":"GTP + H2O => GDP + H(+) + phosphate"}
{"X":22614,"RHEA_ID":19671,"compounds":"GDP + H(+) + phosphate => GTP + H2O"}
{"X":22615,"RHEA_ID":30220,"compounds":"dimethyl sulfoxide + H2O + NAD(+) => dimethyl sulfone + H(+) + NADH"}
{"X":22616,"RHEA_ID":30221,"DIRECTION":"RL","MASTER_ID":30219,"metacyc":"RXN-9762","compounds":"dimethyl sulfone + H(+) + NADH => dimethyl sulfoxide + H2O + NAD(+)"}
{"X":22617,"RHEA_ID":30223,"DIRECTION":"UN","MASTER_ID":30223,"ec":"1.8.2.3","compounds":"2 [Fe(III)cytochrome c] + hydrogen sulfide = 2 [Fe(II)cytochrome c] + H(+) + sulfur"}
{"X":22618,"RHEA_ID":30224,"DIRECTION":"LR","MASTER_ID":30223,"metacyc":"RXN-8156","compounds":"2 [Fe(III)cytochrome c] + hydrogen sulfide => 2 [Fe(II)cytochrome c] + H(+) + sulfur"}
{"X":22619,"RHEA_ID":30225,"compounds":"2 [Fe(II)cytochrome c] + H(+) + sulfur => 2 [Fe(III)cytochrome c] + hydrogen sulfide"}
{"X":22620,"RHEA_ID":19673,"DIRECTION":"UN","MASTER_ID":19673,"ec":"1.13.11.35","compounds":"1,2,3-trihydroxybenzene + O2 = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+)"}
{"X":22621,"RHEA_ID":19674,"DIRECTION":"LR","MASTER_ID":19673,"metacyc":"PYROGALLOL-12-OXYGENASE-RXN","compounds":"1,2,3-trihydroxybenzene + O2 => (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+)"}
{"X":22622,"RHEA_ID":19675,"compounds":"(2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+) => 1,2,3-trihydroxybenzene + O2"}
{"X":22623,"RHEA_ID":30229,"compounds":"2 [Fe(II)-cytochrome c2] + dimethyl sulfoxide + 2 H(+) => 2 [Fe(III)-cytochrome c2] + dimethyl sulfide + H2O"}
{"X":22624,"RHEA_ID":19677,"DIRECTION":"UN","MASTER_ID":19677,"ec":"1.13.11.51","compounds":"9'-cis-neoxanthin + O2 = (3S,5R,6R)-3,5-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin"}
{"X":22625,"RHEA_ID":19678,"DIRECTION":"LR","MASTER_ID":19677,"metacyc":"RXN-698","compounds":"9'-cis-neoxanthin + O2 => (3S,5R,6R)-3,5-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin"}
{"X":22626,"RHEA_ID":19679,"compounds":"(3S,5R,6R)-3,5-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin => 9'-cis-neoxanthin + O2"}
{"X":22627,"RHEA_ID":30233,"compounds":"(2E,6E)-farnesal + H2O2 + L-cysteine => H2O + O2 + S-(2E,6E)-farnesyl-L-cysteine"}
{"X":22628,"RHEA_ID":19681,"DIRECTION":"UN","MASTER_ID":19681,"ec":"6.2.1.11","compounds":"ATP + biotin + CoA = AMP + biotinyl-CoA + diphosphate"}
{"X":22629,"RHEA_ID":19682,"DIRECTION":"LR","MASTER_ID":19681,"metacyc":"BIOTIN--COA-LIGASE-RXN","compounds":"ATP + biotin + CoA => AMP + biotinyl-CoA + diphosphate"}
{"X":22630,"RHEA_ID":19683,"compounds":"AMP + biotinyl-CoA + diphosphate => ATP + biotin + CoA"}
{"X":22631,"RHEA_ID":30237,"compounds":"2 H(+) + L-glutamate + NADH => H2O + L-glutamate 5-semialdehyde + NAD(+)"}
{"X":22632,"RHEA_ID":19685,"DIRECTION":"UN","MASTER_ID":19685,"ec":"2.3.1.110","compounds":"(E)-feruloyl-CoA + tyramine = CoA + H(+) + N-[(E)-feruloyl]tyramine"}
{"X":22633,"RHEA_ID":19686,"compounds":"(E)-feruloyl-CoA + tyramine => CoA + H(+) + N-[(E)-feruloyl]tyramine"}
{"X":22634,"RHEA_ID":19687,"compounds":"CoA + H(+) + N-[(E)-feruloyl]tyramine => (E)-feruloyl-CoA + tyramine"}
{"X":22635,"RHEA_ID":30241,"compounds":"n a quinol + n sulfur => n a quinone + n H(+) + n hydrogen sulfide"}
{"X":22636,"RHEA_ID":19689,"DIRECTION":"UN","MASTER_ID":19689,"ec":"4.1.2.19","compounds":"L-rhamnulose 1-phosphate = (S)-lactaldehyde + dihydroxyacetone phosphate"}
{"X":22637,"RHEA_ID":19690,"compounds":"L-rhamnulose 1-phosphate => (S)-lactaldehyde + dihydroxyacetone phosphate"}
{"X":22638,"RHEA_ID":19691,"compounds":"(S)-lactaldehyde + dihydroxyacetone phosphate => L-rhamnulose 1-phosphate"}
{"X":22639,"RHEA_ID":30245,"compounds":"2 H2O + 4 monodehydro-L-ascorbate radical => 4 L-ascorbate + O2"}
{"X":22640,"RHEA_ID":19693,"DIRECTION":"UN","MASTER_ID":19693,"ec":"1.2.1.100","compounds":"5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H2O + NAD(+) = 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + 2 H(+) + NADH"}
{"X":22641,"RHEA_ID":19694,"DIRECTION":"LR","MASTER_ID":19693,"metacyc":"RXN-8756","compounds":"5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H2O + NAD(+) => 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + 2 H(+) + NADH"}
{"X":22642,"RHEA_ID":19695,"compounds":"5-hydroxy-6-methylpyridine-3,4-dicarboxylate + 2 H(+) + NADH => 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H2O + NAD(+)"}
{"X":22643,"RHEA_ID":30249,"compounds":"O2 + 2 plastoquinol-9 => 2 H2O + 4 hnu + 2 plastoquinone-9"}
{"X":22644,"RHEA_ID":19697,"DIRECTION":"UN","MASTER_ID":19697,"ec":"3.1.1.63","compounds":"11-cis-retinyl hexadecanoate + H2O = 11-cis-retinol + H(+) + hexadecanoate"}
{"X":22645,"RHEA_ID":19698,"DIRECTION":"LR","MASTER_ID":19697,"metacyc":"11-CIS-RETINYL-PALMITATE-HYDROLASE-RXN","compounds":"11-cis-retinyl hexadecanoate + H2O => 11-cis-retinol + H(+) + hexadecanoate"}
{"X":22646,"RHEA_ID":19699,"compounds":"11-cis-retinol + H(+) + hexadecanoate => 11-cis-retinyl hexadecanoate + H2O"}
{"X":22647,"RHEA_ID":30253,"compounds":"2 a ubiquinone + n H(+)(out) + 2 H2O => 2 a ubiquinol + n H(+)(in) + O2"}
{"X":22648,"RHEA_ID":19701,"DIRECTION":"UN","MASTER_ID":19701,"ec":"2.4.2.35","metacyc":"2.4.2.35-RXN","compounds":"a flavonol 3-O-glycoside + UDP-alpha-D-xylose = a flavonol 3-O-[beta-D-xylosyl-(1->2)-beta-D-glycoside] + H(+) + UDP"}
{"X":22649,"RHEA_ID":19702,"compounds":"a flavonol 3-O-glycoside + UDP-alpha-D-xylose => a flavonol 3-O-[beta-D-xylosyl-(1->2)-beta-D-glycoside] + H(+) + UDP"}
{"X":22650,"RHEA_ID":19703,"compounds":"a flavonol 3-O-[beta-D-xylosyl-(1->2)-beta-D-glycoside] + H(+) + UDP => a flavonol 3-O-glycoside + UDP-alpha-D-xylose"}
{"X":22651,"RHEA_ID":30257,"compounds":"2 a ubiquinone + 2 H2O => 2 a ubiquinol + O2"}
{"X":22652,"RHEA_ID":19705,"DIRECTION":"UN","MASTER_ID":19705,"ec":"1.2.1.42","compounds":"CoA + hexadecanal + NAD(+) = H(+) + hexadecanoyl-CoA + NADH"}
{"X":22653,"RHEA_ID":19706,"DIRECTION":"LR","MASTER_ID":19705,"metacyc":"1.2.1.42-RXN","compounds":"CoA + hexadecanal + NAD(+) => H(+) + hexadecanoyl-CoA + NADH"}
{"X":22654,"RHEA_ID":19707,"compounds":"H(+) + hexadecanoyl-CoA + NADH => CoA + hexadecanal + NAD(+)"}
{"X":22655,"RHEA_ID":30261,"compounds":"2 a menaquinone + 2 H2O => 2 a menaquinol + O2"}
{"X":22656,"RHEA_ID":19709,"DIRECTION":"UN","MASTER_ID":19709,"ec":"2.3.1.51","compounds":"a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA"}
{"X":22657,"RHEA_ID":19710,"DIRECTION":"LR","MASTER_ID":19709,"ecocyc":"RXN-1623","metacyc":"RXN-1623","compounds":"a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphate + CoA"}
{"X":22658,"RHEA_ID":19711,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphate + CoA => a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA"}
{"X":22659,"RHEA_ID":19713,"DIRECTION":"UN","MASTER_ID":19713,"ec":"6.2.1.15","compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate"}
{"X":22660,"RHEA_ID":19714,"DIRECTION":"LR","MASTER_ID":19713,"metacyc":"ARACHIDONATE--COA-LIGASE-RXN","reactome":"R-HSA-548843.2","compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate"}
{"X":22661,"RHEA_ID":19715,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA"}
{"X":22662,"RHEA_ID":30269,"compounds":"L-ascorbate + L-dehydroascorbate => 2 monodehydro-L-ascorbate radical"}
{"X":22663,"RHEA_ID":19717,"DIRECTION":"UN","MASTER_ID":19717,"ec":"4.1.1.53","compounds":"H(+) + L-phenylalanine = 2-phenylethylamine + CO2"}
{"X":22664,"RHEA_ID":19718,"DIRECTION":"LR","MASTER_ID":19717,"metacyc":"PHENYLALANINE-DECARBOXYLASE-RXN","compounds":"H(+) + L-phenylalanine => 2-phenylethylamine + CO2"}
{"X":22665,"RHEA_ID":19719,"compounds":"2-phenylethylamine + CO2 => H(+) + L-phenylalanine"}
{"X":22666,"RHEA_ID":30273,"compounds":"2 (3,4-dimethoxyphenyl)methanol radical + 2 H2O => 2 (3,4-dimethoxyphenyl)methanol + H2O2"}
{"X":22667,"RHEA_ID":19721,"DIRECTION":"UN","MASTER_ID":19721,"ec":"1.14.19.1","compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":22668,"RHEA_ID":19722,"DIRECTION":"LR","MASTER_ID":19721,"metacyc":"1.14.19.1-RXN","compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + octadecanoyl-CoA => (9Z)-octadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":22669,"RHEA_ID":19723,"compounds":"(9Z)-octadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + octadecanoyl-CoA"}
{"X":22670,"RHEA_ID":19725,"DIRECTION":"UN","MASTER_ID":19725,"ec":"4.1.1.67","metacyc":"UDP-GALACTURONATE-DECARBOXYLASE-RXN","compounds":"H(+) + UDP-alpha-D-galacturonate = CO2 + UDP-beta-L-arabinopyranose"}
{"X":22671,"RHEA_ID":19726,"compounds":"H(+) + UDP-alpha-D-galacturonate => CO2 + UDP-beta-L-arabinopyranose"}
{"X":22672,"RHEA_ID":19727,"compounds":"CO2 + UDP-beta-L-arabinopyranose => H(+) + UDP-alpha-D-galacturonate"}
{"X":22673,"RHEA_ID":30281,"DIRECTION":"RL","MASTER_ID":30279,"metacyc":"RXN-12215","compounds":"3 H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin] => 2 H2 + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":22674,"RHEA_ID":19729,"DIRECTION":"UN","MASTER_ID":19729,"ec":"4.1.1.4","compounds":"acetoacetate + H(+) = acetone + CO2"}
{"X":22675,"RHEA_ID":19730,"DIRECTION":"LR","MASTER_ID":19729,"metacyc":"ACETOACETATE-DECARBOXYLASE-RXN","compounds":"acetoacetate + H(+) => acetone + CO2"}
{"X":22676,"RHEA_ID":19731,"compounds":"acetone + CO2 => acetoacetate + H(+)"}
{"X":22677,"RHEA_ID":19733,"DIRECTION":"UN","MASTER_ID":19733,"ec":"1.1.1.396","compounds":"3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + NAD(+) = bacteriochlorophyllide a + H(+) + NADH"}
{"X":22678,"RHEA_ID":19734,"DIRECTION":"LR","MASTER_ID":19733,"metacyc":"RXN-8787","compounds":"3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + NAD(+) => bacteriochlorophyllide a + H(+) + NADH"}
{"X":22679,"RHEA_ID":19735,"compounds":"bacteriochlorophyllide a + H(+) + NADH => 3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + NAD(+)"}
{"X":22680,"RHEA_ID":30289,"compounds":"9,9',15-tri-cis-zeta-carotene + 2 a plastoquinol => 15-cis-phytoene + 2 a plastoquinone"}
{"X":22681,"RHEA_ID":19737,"DIRECTION":"UN","MASTER_ID":19737,"ec":"3.5.1.94","compounds":"4-(gamma-L-glutamylamino)butanoate + H2O = 4-aminobutanoate + L-glutamate"}
{"X":22682,"RHEA_ID":19738,"DIRECTION":"LR","MASTER_ID":19737,"ecocyc":"RXN0-3942","metacyc":"RXN0-3942","compounds":"4-(gamma-L-glutamylamino)butanoate + H2O => 4-aminobutanoate + L-glutamate"}
{"X":22683,"RHEA_ID":19739,"compounds":"4-aminobutanoate + L-glutamate => 4-(gamma-L-glutamylamino)butanoate + H2O"}
{"X":22684,"RHEA_ID":30293,"compounds":"(9S)-hydroperoxy-(10E,12Z)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2"}
{"X":22685,"RHEA_ID":19741,"DIRECTION":"UN","MASTER_ID":19741,"ec":"3.1.2.10","compounds":"formyl-CoA + H2O = CoA + formate + H(+)"}
{"X":22686,"RHEA_ID":19742,"DIRECTION":"LR","MASTER_ID":19741,"metacyc":"FORMYL-COA-HYDROLASE-RXN","reactome":"R-HSA-389580.1","compounds":"formyl-CoA + H2O => CoA + formate + H(+)"}
{"X":22687,"RHEA_ID":19743,"compounds":"CoA + formate + H(+) => formyl-CoA + H2O"}
{"X":22688,"RHEA_ID":30297,"DIRECTION":"RL","MASTER_ID":30295,"metacyc":"RXN-14117","compounds":"GDP + H(+) + phosphoenolpyruvate => GTP + pyruvate"}
{"X":22689,"RHEA_ID":19745,"DIRECTION":"UN","MASTER_ID":19745,"ec":"1.21.99.4","compounds":"3,3',5-triiodo-L-thyronine + A + H(+) + iodide = AH2 + L-thyroxine"}
{"X":22690,"RHEA_ID":19746,"compounds":"3,3',5-triiodo-L-thyronine + A + H(+) + iodide => AH2 + L-thyroxine"}
{"X":22691,"RHEA_ID":19747,"DIRECTION":"RL","MASTER_ID":19745,"metacyc":"THYROXINE-DEIODINASE-RXN","compounds":"AH2 + L-thyroxine => 3,3',5-triiodo-L-thyronine + A + H(+) + iodide"}
{"X":22692,"RHEA_ID":30301,"compounds":"a nucleobase within DNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + a methylated nucleobase within DNA + O2"}
{"X":22693,"RHEA_ID":19749,"DIRECTION":"UN","MASTER_ID":19749,"ec":"2.4.1.183","compounds":"[(1->3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->3)-alpha-D-glucosyl](n+1) + H(+) + UDP"}
{"X":22694,"RHEA_ID":19750,"compounds":"[(1->3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose => [(1->3)-alpha-D-glucosyl](n+1) + H(+) + UDP"}
{"X":22695,"RHEA_ID":19751,"compounds":"[(1->3)-alpha-D-glucosyl](n+1) + H(+) + UDP => [(1->3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose"}
{"X":22696,"RHEA_ID":30305,"compounds":"germacra-1(10),4,11(13)-trien-12-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => (+)-(R)-germacrene A + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]"}
{"X":22697,"RHEA_ID":19753,"DIRECTION":"UN","MASTER_ID":19753,"ec":"6.3.1.14","compounds":"ATP + diphthine-[translation elongation factor 2] + NH4(+) = AMP + diphosphate + diphthamide-[translation elongation factor 2] + H(+)"}
{"X":22698,"RHEA_ID":19754,"DIRECTION":"LR","MASTER_ID":19753,"metacyc":"DIPHTINE--AMMONIA-LIGASE-RXN","compounds":"ATP + diphthine-[translation elongation factor 2] + NH4(+) => AMP + diphosphate + diphthamide-[translation elongation factor 2] + H(+)"}
{"X":22699,"RHEA_ID":19755,"compounds":"AMP + diphosphate + diphthamide-[translation elongation factor 2] + H(+) => ATP + diphthine-[translation elongation factor 2] + NH4(+)"}
{"X":22700,"RHEA_ID":30309,"compounds":"formaldehyde + H2O + NADP(+) + xanthine => 7-methylxanthine + H(+) + NADPH + O2"}
{"X":22701,"RHEA_ID":19757,"DIRECTION":"UN","MASTER_ID":19757,"ec":"4.3.1.20","compounds":"(3R)-3-hydroxy-L-aspartate = NH4(+) + oxaloacetate"}
{"X":22702,"RHEA_ID":19758,"DIRECTION":"LR","MASTER_ID":19757,"metacyc":"4.3.1.20-RXN","compounds":"(3R)-3-hydroxy-L-aspartate => NH4(+) + oxaloacetate"}
{"X":22703,"RHEA_ID":19759,"compounds":"NH4(+) + oxaloacetate => (3R)-3-hydroxy-L-aspartate"}
{"X":22704,"RHEA_ID":30313,"compounds":"formaldehyde + H2O + NAD(+) + xanthine => 7-methylxanthine + H(+) + NADH + O2"}
{"X":22705,"RHEA_ID":19761,"compounds":"FMN-N(5)-oxide + H(+) + NADH = FMN + H2O + NAD(+)"}
{"X":22706,"RHEA_ID":19762,"DIRECTION":"LR","MASTER_ID":19761,"metacyc":"RXN-20706","compounds":"FMN-N(5)-oxide + H(+) + NADH => FMN + H2O + NAD(+)"}
{"X":22707,"RHEA_ID":19763,"compounds":"FMN + H2O + NAD(+) => FMN-N(5)-oxide + H(+) + NADH"}
{"X":22708,"RHEA_ID":19764,"compounds":"FMN-N(5)-oxide + H(+) + NADH <=> FMN + H2O + NAD(+)"}
{"X":22709,"RHEA_ID":19765,"DIRECTION":"UN","MASTER_ID":19765,"ec":"4.2.1.30","compounds":"glycerol = 3-hydroxypropanal + H2O"}
{"X":22710,"RHEA_ID":19766,"DIRECTION":"LR","MASTER_ID":19765,"metacyc":"GLYCEROL-DEHYDRATASE-RXN","compounds":"glycerol => 3-hydroxypropanal + H2O"}
{"X":22711,"RHEA_ID":19767,"compounds":"3-hydroxypropanal + H2O => glycerol"}
{"X":22712,"RHEA_ID":19769,"DIRECTION":"UN","MASTER_ID":19769,"ec":"4.2.1.97","compounds":"phaseollidin hydrate = H2O + phaseollidin"}
{"X":22713,"RHEA_ID":19770,"compounds":"phaseollidin hydrate => H2O + phaseollidin"}
{"X":22714,"RHEA_ID":19771,"DIRECTION":"RL","MASTER_ID":19769,"metacyc":"4.2.1.97-RXN","compounds":"H2O + phaseollidin => phaseollidin hydrate"}
{"X":22715,"RHEA_ID":30325,"compounds":"beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => all-trans-beta-carotene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":22716,"RHEA_ID":19773,"DIRECTION":"UN","MASTER_ID":19773,"ec":"1.1.1.177","metacyc":"1.1.1.177-RXN","compounds":"NADP(+) + sn-glycerol 3-phosphate = D-glyceraldehyde 3-phosphate + H(+) + NADPH"}
{"X":22717,"RHEA_ID":19774,"compounds":"NADP(+) + sn-glycerol 3-phosphate => D-glyceraldehyde 3-phosphate + H(+) + NADPH"}
{"X":22718,"RHEA_ID":19775,"compounds":"D-glyceraldehyde 3-phosphate + H(+) + NADPH => NADP(+) + sn-glycerol 3-phosphate"}
{"X":22719,"RHEA_ID":30329,"compounds":"all-trans-zeaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":22720,"RHEA_ID":19777,"DIRECTION":"UN","MASTER_ID":19777,"ec":"1.5.99.3","metacyc":"L-PIPECOLATE-DEHYDROGENASE-RXN","compounds":"A + L-pipecolate = AH2 + H(+) + L-1-piperideine-6-carboxylate"}
{"X":22721,"RHEA_ID":19778,"compounds":"A + L-pipecolate => AH2 + H(+) + L-1-piperideine-6-carboxylate"}
{"X":22722,"RHEA_ID":19779,"compounds":"AH2 + H(+) + L-1-piperideine-6-carboxylate => A + L-pipecolate"}
{"X":22723,"RHEA_ID":30333,"compounds":"all-trans-zeaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => all-trans-beta-carotene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]"}
{"X":22724,"RHEA_ID":19781,"DIRECTION":"UN","MASTER_ID":19781,"ec":"2.6.1.24","compounds":"2-oxoglutarate + 3,5-diiodo-L-tyrosine = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + L-glutamate"}
{"X":22725,"RHEA_ID":19782,"compounds":"2-oxoglutarate + 3,5-diiodo-L-tyrosine => 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + L-glutamate"}
{"X":22726,"RHEA_ID":19783,"compounds":"3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + L-glutamate => 2-oxoglutarate + 3,5-diiodo-L-tyrosine"}
{"X":22727,"RHEA_ID":30337,"compounds":"NH4(+) + UTP => CTP + H(+) + H2O"}
{"X":22728,"RHEA_ID":19785,"DIRECTION":"UN","MASTER_ID":19785,"ec":"1.14.11.21","compounds":"2-oxoglutarate + dihydroclavaminate + O2 = clavaminate + CO2 + H2O + succinate"}
{"X":22729,"RHEA_ID":19786,"DIRECTION":"LR","MASTER_ID":19785,"metacyc":"RXN-6267","compounds":"2-oxoglutarate + dihydroclavaminate + O2 => clavaminate + CO2 + H2O + succinate"}
{"X":22730,"RHEA_ID":19787,"compounds":"clavaminate + CO2 + H2O + succinate => 2-oxoglutarate + dihydroclavaminate + O2"}
{"X":22731,"RHEA_ID":30340,"DIRECTION":"LR","MASTER_ID":30339,"metacyc":"AROMATIC-L-AMINO-ACID-DECARBOXYLASE-RXN","compounds":"H(+) + L-tryptophan => CO2 + tryptamine"}
{"X":22732,"RHEA_ID":19789,"DIRECTION":"UN","MASTER_ID":19789,"ec":"1.7.1.11","metacyc":"1.6.6.12-RXN","compounds":"4-(dimethylamino)azobenzene + H2O + NADP(+) = 4-(dimethylamino)phenylazoxybenzene + H(+) + NADPH"}
{"X":22733,"RHEA_ID":19790,"compounds":"4-(dimethylamino)azobenzene + H2O + NADP(+) => 4-(dimethylamino)phenylazoxybenzene + H(+) + NADPH"}
{"X":22734,"RHEA_ID":19791,"compounds":"4-(dimethylamino)phenylazoxybenzene + H(+) + NADPH => 4-(dimethylamino)azobenzene + H2O + NADP(+)"}
{"X":22735,"RHEA_ID":30344,"compounds":"FAD + H(+) + succinate => FADH2 + fumarate"}
{"X":22736,"RHEA_ID":19793,"DIRECTION":"UN","MASTER_ID":19793,"ec":"1.5.8.3","compounds":"H(+) + H2O + oxidized [electron-transfer flavoprotein] + sarcosine = formaldehyde + glycine + reduced [electron-transfer flavoprotein]"}
{"X":22737,"RHEA_ID":19794,"DIRECTION":"LR","MASTER_ID":19793,"metacyc":"SARCOSINE-DEHYDROGENASE-RXN","compounds":"H(+) + H2O + oxidized [electron-transfer flavoprotein] + sarcosine => formaldehyde + glycine + reduced [electron-transfer flavoprotein]"}
{"X":22738,"RHEA_ID":19795,"compounds":"formaldehyde + glycine + reduced [electron-transfer flavoprotein] => H(+) + H2O + oxidized [electron-transfer flavoprotein] + sarcosine"}
{"X":22739,"RHEA_ID":19797,"DIRECTION":"UN","MASTER_ID":19797,"ec":"3.1.3.56","compounds":"1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate"}
{"X":22740,"RHEA_ID":19798,"DIRECTION":"LR","MASTER_ID":19797,"metacyc":"3.1.3.56-RXN","reactome":"R-HSA-1855222.2","compounds":"1D-myo-inositol 1,4,5-trisphosphate + H2O => 1D-myo-inositol 1,4-bisphosphate + phosphate"}
{"X":22741,"RHEA_ID":19798,"DIRECTION":"LR","MASTER_ID":19797,"metacyc":"3.1.3.56-RXN","reactome":"R-HSA-1855174.2","compounds":"1D-myo-inositol 1,4,5-trisphosphate + H2O => 1D-myo-inositol 1,4-bisphosphate + phosphate"}
{"X":22742,"RHEA_ID":19799,"compounds":"1D-myo-inositol 1,4-bisphosphate + phosphate => 1D-myo-inositol 1,4,5-trisphosphate + H2O"}
{"X":22743,"RHEA_ID":30353,"compounds":"5-hydroxypyrrole-2-carboxylate + H2O + NAD(+) => H(+) + NADH + O2 + pyrrole-2-carboxylate"}
{"X":22744,"RHEA_ID":19801,"DIRECTION":"UN","MASTER_ID":19801,"ec":"2.7.7.3","compounds":"ATP + D-pantetheine 4'-phosphate + H(+) = 3'-dephospho-CoA + diphosphate"}
{"X":22745,"RHEA_ID":19802,"DIRECTION":"LR","MASTER_ID":19801,"ecocyc":"PANTEPADENYLYLTRAN-RXN","metacyc":"PANTEPADENYLYLTRAN-RXN","compounds":"ATP + D-pantetheine 4'-phosphate + H(+) => 3'-dephospho-CoA + diphosphate"}
{"X":22746,"RHEA_ID":19803,"compounds":"3'-dephospho-CoA + diphosphate => ATP + D-pantetheine 4'-phosphate + H(+)"}
{"X":22747,"RHEA_ID":30357,"compounds":"a quinone + H2O + methanol => a quinol + methane + O2"}
{"X":22748,"RHEA_ID":19805,"DIRECTION":"UN","MASTER_ID":19805,"ec":"2.4.2.1","compounds":"a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate"}
{"X":22749,"RHEA_ID":19806,"compounds":"a purine D-ribonucleoside + phosphate => a purine nucleobase + alpha-D-ribose 1-phosphate"}
{"X":22750,"RHEA_ID":19807,"compounds":"a purine nucleobase + alpha-D-ribose 1-phosphate => a purine D-ribonucleoside + phosphate"}
{"X":22751,"RHEA_ID":30361,"compounds":"chlorophyllide b + 3 H2O + 2 NADP(+) => chlorophyllide a + 2 H(+) + 2 NADPH + 2 O2"}
{"X":22752,"RHEA_ID":19809,"DIRECTION":"UN","MASTER_ID":19809,"ec":"3.5.1.116","compounds":"(S)-ureidoglycolate + 2 H(+) + H2O = CO2 + glyoxylate + 2 NH4(+)"}
{"X":22753,"RHEA_ID":19810,"DIRECTION":"LR","MASTER_ID":19809,"metacyc":"UREIDOGLYCOLATE-HYDROLASE-RXN","compounds":"(S)-ureidoglycolate + 2 H(+) + H2O => CO2 + glyoxylate + 2 NH4(+)"}
{"X":22754,"RHEA_ID":19811,"compounds":"CO2 + glyoxylate + 2 NH4(+) => (S)-ureidoglycolate + 2 H(+) + H2O"}
{"X":22755,"RHEA_ID":19813,"DIRECTION":"UN","MASTER_ID":19813,"ec":"2.6.1.14","compounds":"a 2-oxocarboxylate + L-asparagine = 2-oxosuccinamate + an L-alpha-amino acid"}
{"X":22756,"RHEA_ID":19814,"compounds":"a 2-oxocarboxylate + L-asparagine => 2-oxosuccinamate + an L-alpha-amino acid"}
{"X":22757,"RHEA_ID":19815,"compounds":"2-oxosuccinamate + an L-alpha-amino acid => a 2-oxocarboxylate + L-asparagine"}
{"X":22758,"RHEA_ID":30369,"compounds":"adenosylcob(III)alamin + phosphate => adenosylcob(III)alamin 5'-phosphate + H2O"}
{"X":22759,"RHEA_ID":19817,"DIRECTION":"UN","MASTER_ID":19817,"ec":"1.5.1.20","compounds":"(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH"}
{"X":22760,"RHEA_ID":19818,"compounds":"(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH"}
{"X":22761,"RHEA_ID":19819,"DIRECTION":"RL","MASTER_ID":19817,"macie":"M0120","compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+)"}
{"X":22762,"RHEA_ID":30373,"compounds":"(-)-geosmin + acetone => (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O"}
{"X":22763,"RHEA_ID":19821,"DIRECTION":"UN","MASTER_ID":19821,"ec":"1.5.1.20","compounds":"(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH"}
{"X":22764,"RHEA_ID":19822,"compounds":"(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH"}
{"X":22765,"RHEA_ID":19823,"compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+)"}
{"X":22766,"RHEA_ID":30377,"compounds":"(+)-thujopsene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":22767,"RHEA_ID":19825,"DIRECTION":"UN","MASTER_ID":19825,"ec":"4.2.3.9","compounds":"(2E,6E)-farnesyl diphosphate = (+)-aristolochene + diphosphate"}
{"X":22768,"RHEA_ID":19826,"DIRECTION":"LR","MASTER_ID":19825,"metacyc":"ARISTOLOCHENE-SYNTHASE-RXN","compounds":"(2E,6E)-farnesyl diphosphate => (+)-aristolochene + diphosphate"}
{"X":22769,"RHEA_ID":19827,"compounds":"(+)-aristolochene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":22770,"RHEA_ID":30381,"compounds":"(+)-beta-chamigrene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":22771,"RHEA_ID":19829,"DIRECTION":"UN","MASTER_ID":19829,"ec":"1.1.3.13","compounds":"a primary alcohol + O2 = an aldehyde + H2O2"}
{"X":22772,"RHEA_ID":19830,"compounds":"a primary alcohol + O2 => an aldehyde + H2O2"}
{"X":22773,"RHEA_ID":19831,"compounds":"an aldehyde + H2O2 => a primary alcohol + O2"}
{"X":22774,"RHEA_ID":19833,"DIRECTION":"UN","MASTER_ID":19833,"ec":"3.5.1.10","compounds":"(6S)-10-formyltetrahydrofolate + H2O = (6S)-5,6,7,8-tetrahydrofolate + formate + H(+)"}
{"X":22775,"RHEA_ID":19834,"DIRECTION":"LR","MASTER_ID":19833,"ecocyc":"FORMYLTHFDEFORMYL-RXN","metacyc":"FORMYLTHFDEFORMYL-RXN","compounds":"(6S)-10-formyltetrahydrofolate + H2O => (6S)-5,6,7,8-tetrahydrofolate + formate + H(+)"}
{"X":22776,"RHEA_ID":19835,"compounds":"(6S)-5,6,7,8-tetrahydrofolate + formate + H(+) => (6S)-10-formyltetrahydrofolate + H2O"}
{"X":22777,"RHEA_ID":30389,"compounds":"alpha-D-glucose 1-phosphate + GDP + H(+) => GDP-alpha-D-glucose + phosphate"}
{"X":22778,"RHEA_ID":40365,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP"}
{"X":22779,"RHEA_ID":19838,"compounds":"D-sorbitol 6-phosphate + NAD(+) => beta-D-fructose 6-phosphate + H(+) + NADH"}
{"X":22780,"RHEA_ID":19839,"compounds":"beta-D-fructose 6-phosphate + H(+) + NADH => D-sorbitol 6-phosphate + NAD(+)"}
{"X":22781,"RHEA_ID":30393,"compounds":"2-oxoglutaramate + L-methionine => 4-methylsulfanyl-2-oxobutanoate + L-glutamine"}
{"X":22782,"RHEA_ID":30394,"DIRECTION":"BI","MASTER_ID":30391,"metacyc":"RXN-15650","compounds":"4-methylsulfanyl-2-oxobutanoate + L-glutamine <=> 2-oxoglutaramate + L-methionine"}
{"X":22783,"RHEA_ID":19842,"compounds":"H2O + N-formylmethanofuran + 2 oxidized [2Fe-2S]-[ferredoxin] => CO2 + H(+) + methanofuran + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":22784,"RHEA_ID":19843,"compounds":"CO2 + H(+) + methanofuran + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + N-formylmethanofuran + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":22785,"RHEA_ID":30401,"compounds":"alpha-cryptoxanthin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => alpha-carotene + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":22786,"RHEA_ID":19845,"DIRECTION":"UN","MASTER_ID":19845,"ec":"2.5.1.38","compounds":"nocardicin E + S-adenosyl-L-methionine = H(+) + isonocardicin A + S-methyl-5'-thioadenosine"}
{"X":22787,"RHEA_ID":19846,"compounds":"nocardicin E + S-adenosyl-L-methionine => H(+) + isonocardicin A + S-methyl-5'-thioadenosine"}
{"X":22788,"RHEA_ID":19847,"compounds":"H(+) + isonocardicin A + S-methyl-5'-thioadenosine => nocardicin E + S-adenosyl-L-methionine"}
{"X":22789,"RHEA_ID":30405,"compounds":"Fe(2+)(out) + H(+) + monodehydro-L-ascorbate radical(in) => Fe(3+)(out) + L-ascorbate(in)"}
{"X":22790,"RHEA_ID":30406,"compounds":"Fe(3+)(out) + L-ascorbate(in) <=> Fe(2+)(out) + H(+) + monodehydro-L-ascorbate radical(in)"}
{"X":22791,"RHEA_ID":19850,"compounds":"H2O + NADP(+) => ADP-D-ribose 2'-phosphate + H(+) + nicotinamide"}
{"X":22792,"RHEA_ID":19851,"compounds":"ADP-D-ribose 2'-phosphate + H(+) + nicotinamide => H2O + NADP(+)"}
{"X":22793,"RHEA_ID":30409,"compounds":"oxidized [plastocyanin] + reduced [2Fe-2S]-[ferredoxin] => hnu + oxidized [2Fe-2S]-[ferredoxin] + reduced [plastocyanin]"}
{"X":22794,"RHEA_ID":19858,"compounds":"a 16alpha-hydroxysteroid + NADP(+) => a 16-oxosteroid + H(+) + NADPH"}
{"X":22795,"RHEA_ID":19859,"compounds":"a 16-oxosteroid + H(+) + NADPH => a 16alpha-hydroxysteroid + NADP(+)"}
{"X":22796,"RHEA_ID":30413,"compounds":"benzyl benzoate + CoA => benzoyl-CoA + benzyl alcohol"}
{"X":22797,"RHEA_ID":40385,"compounds":"1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+) => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP"}
{"X":22798,"RHEA_ID":19862,"compounds":"a 16alpha-hydroxysteroid + NAD(+) => a 16-oxosteroid + H(+) + NADH"}
{"X":22799,"RHEA_ID":19863,"compounds":"a 16-oxosteroid + H(+) + NADH => a 16alpha-hydroxysteroid + NAD(+)"}
{"X":22800,"RHEA_ID":30417,"compounds":"formate + H2O + heptadecane + 2 NADP(+) => H(+) + 2 NADPH + O2 + octadecanal"}
{"X":22801,"RHEA_ID":30418,"compounds":"H(+) + 2 NADPH + O2 + octadecanal <=> formate + H2O + heptadecane + 2 NADP(+)"}
{"X":22802,"RHEA_ID":19866,"DIRECTION":"LR","MASTER_ID":19865,"ecocyc":"UROGENDECARBOX-RXN","metacyc":"UROGENDECARBOX-RXN","reactome":"R-HSA-189425.1","compounds":"4 H(+) + uroporphyrinogen III => 4 CO2 + coproporphyrinogen III"}
{"X":22803,"RHEA_ID":19867,"compounds":"4 CO2 + coproporphyrinogen III => 4 H(+) + uroporphyrinogen III"}
{"X":22804,"RHEA_ID":30425,"compounds":"(+)-delta-selinene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":22805,"RHEA_ID":19869,"DIRECTION":"UN","MASTER_ID":19869,"ec":"2.3.1.13","compounds":"an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)"}
{"X":22806,"RHEA_ID":30427,"DIRECTION":"UN","MASTER_ID":30427,"ec":"4.2.3.77","compounds":"(2E,6E)-farnesyl diphosphate = (+)-germacrene D + diphosphate"}
{"X":22807,"RHEA_ID":19871,"compounds":"an N-acylglycine + CoA + H(+) => an acyl-CoA + glycine"}
{"X":22808,"RHEA_ID":19873,"DIRECTION":"UN","MASTER_ID":19873,"ec":"3.1.6.2","compounds":"3beta-sulfooxy-androst-5-en-17-one + H2O = 3beta-hydroxyandrost-5-en-17-one + H(+) + sulfate"}
{"X":22809,"RHEA_ID":19874,"DIRECTION":"LR","MASTER_ID":19873,"metacyc":"STERYL-SULFATASE-RXN","reactome":"R-HSA-1606839.2","compounds":"3beta-sulfooxy-androst-5-en-17-one + H2O => 3beta-hydroxyandrost-5-en-17-one + H(+) + sulfate"}
{"X":22810,"RHEA_ID":19875,"compounds":"3beta-hydroxyandrost-5-en-17-one + H(+) + sulfate => 3beta-sulfooxy-androst-5-en-17-one + H2O"}
{"X":22811,"RHEA_ID":30433,"compounds":"taraxerol => (S)-2,3-epoxysqualene"}
{"X":22812,"RHEA_ID":19877,"DIRECTION":"UN","MASTER_ID":19877,"ec":"2.7.1.67","compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)"}
{"X":22813,"RHEA_ID":30435,"DIRECTION":"UN","MASTER_ID":30435,"ec":"2.3.2.16","compounds":"beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + glycyl-tRNA(Gly) = beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + H(+) + tRNA(Gly)"}
{"X":22814,"RHEA_ID":19879,"compounds":"1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP"}
{"X":22815,"RHEA_ID":30437,"compounds":"beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + H(+) + tRNA(Gly) => beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + glycyl-tRNA(Gly)"}
{"X":22816,"RHEA_ID":19881,"compounds":"GTP + L-lysyl-[protein] = diphosphate + H(+) + N(epsilon)-GMP-L-lysyl-[protein]"}
{"X":22817,"RHEA_ID":19882,"compounds":"GTP + L-lysyl-[protein] => diphosphate + H(+) + N(epsilon)-GMP-L-lysyl-[protein]"}
{"X":22818,"RHEA_ID":30440,"DIRECTION":"LR","MASTER_ID":30439,"metacyc":"RXN-11296","compounds":"beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + 2 glycyl-tRNA(Gly) => 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly)"}
{"X":22819,"RHEA_ID":19884,"compounds":"GTP + L-lysyl-[protein] <=> diphosphate + H(+) + N(epsilon)-GMP-L-lysyl-[protein]"}
{"X":22820,"RHEA_ID":19885,"DIRECTION":"UN","MASTER_ID":19885,"ec":"1.21.3.3","compounds":"(S)-reticuline + O2 = (S)-scoulerine + H(+) + H2O2"}
{"X":22821,"RHEA_ID":19886,"DIRECTION":"LR","MASTER_ID":19885,"metacyc":"RETICULINE-OXIDASE-RXN","compounds":"(S)-reticuline + O2 => (S)-scoulerine + H(+) + H2O2"}
{"X":22822,"RHEA_ID":30444,"DIRECTION":"LR","MASTER_ID":30443,"metacyc":"RXN-11297","compounds":"2 glycyl-tRNA(Gly) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc => 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-penta-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly)"}
{"X":22823,"RHEA_ID":30445,"compounds":"2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-penta-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly) => 2 glycyl-tRNA(Gly) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc"}
{"X":22824,"RHEA_ID":19889,"DIRECTION":"UN","MASTER_ID":19889,"ec":"2.7.7.9","compounds":"alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose"}
{"X":22825,"RHEA_ID":19890,"DIRECTION":"LR","MASTER_ID":19889,"ecocyc":"GLUC1PURIDYLTRANS-RXN","compounds":"alpha-D-glucose 1-phosphate + H(+) + UTP => diphosphate + UDP-alpha-D-glucose"}
{"X":22826,"RHEA_ID":30448,"DIRECTION":"LR","MASTER_ID":30447,"metacyc":"RXN-13109","compounds":"3-methylxanthine + H(+) + NADH + O2 => formaldehyde + H2O + NAD(+) + xanthine"}
{"X":22827,"RHEA_ID":30449,"compounds":"formaldehyde + H2O + NAD(+) + xanthine => 3-methylxanthine + H(+) + NADH + O2"}
{"X":22828,"RHEA_ID":19893,"DIRECTION":"UN","MASTER_ID":19893,"ec":"2.7.4.7","compounds":"4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP = 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP"}
{"X":22829,"RHEA_ID":19894,"DIRECTION":"LR","MASTER_ID":19893,"ecocyc":"PYRIMSYN3-RXN","metacyc":"PYRIMSYN3-RXN","compounds":"4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP => 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP"}
{"X":22830,"RHEA_ID":19895,"compounds":"4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP => 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP"}
{"X":22831,"RHEA_ID":30453,"compounds":"isomultiflorenol => (S)-2,3-epoxysqualene"}
{"X":22832,"RHEA_ID":19897,"DIRECTION":"UN","MASTER_ID":19897,"ec":"1.14.13.39","compounds":"H(+) + 2 L-arginine + 3 NADPH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide"}
{"X":22833,"RHEA_ID":19898,"DIRECTION":"LR","MASTER_ID":19897,"metacyc":"NITRIC-OXIDE-SYNTHASE-RXN","compounds":"H(+) + 2 L-arginine + 3 NADPH + 4 O2 => 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide"}
{"X":22834,"RHEA_ID":30456,"compounds":"(1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + H2O => (-)-geosmin"}
{"X":22835,"RHEA_ID":19899,"compounds":"4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide => H(+) + 2 L-arginine + 3 NADPH + 4 O2"}
{"X":22836,"RHEA_ID":30458,"compounds":"(1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + H2O <=> (-)-geosmin"}
{"X":22837,"RHEA_ID":19901,"DIRECTION":"UN","MASTER_ID":19901,"ec":"1.3.3.10","compounds":"L-tryptophan + O2 = alpha,beta-didehydrotryptophan + H2O2"}
{"X":22838,"RHEA_ID":30460,"compounds":"(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol => (1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + acetone"}
{"X":22839,"RHEA_ID":19903,"compounds":"alpha,beta-didehydrotryptophan + H2O2 => L-tryptophan + O2"}
{"X":22840,"RHEA_ID":30462,"compounds":"(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol <=> (1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + acetone"}
{"X":22841,"RHEA_ID":19905,"compounds":"NAD(+) + spermidine = dehydrospermidine + H(+) + NADH"}
{"X":22842,"RHEA_ID":30464,"DIRECTION":"LR","MASTER_ID":30463,"metacyc":"RXN-10567","compounds":"(2Z,6Z)-farnesyl diphosphate => (+)-alpha-santalene + diphosphate"}
{"X":22843,"RHEA_ID":19907,"compounds":"dehydrospermidine + H(+) + NADH => NAD(+) + spermidine"}
{"X":22844,"RHEA_ID":40433,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O"}
{"X":22845,"RHEA_ID":19909,"DIRECTION":"UN","MASTER_ID":19909,"ec":"1.1.2.3","compounds":"(S)-lactate + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H(+) + pyruvate"}
{"X":22846,"RHEA_ID":30468,"DIRECTION":"LR","MASTER_ID":30467,"metacyc":"RXN-10483","compounds":"(2Z,6Z)-farnesyl diphosphate => (+)-endo-beta-bergamotene + diphosphate"}
{"X":22847,"RHEA_ID":19911,"compounds":"2 [Fe(II)cytochrome c] + 2 H(+) + pyruvate => (S)-lactate + 2 [Fe(III)cytochrome c]"}
{"X":22848,"RHEA_ID":19913,"DIRECTION":"UN","MASTER_ID":19913,"ec":"1.1.1.212","compounds":"a (3R)-hydroxyacyl-[ACP] + NAD(+) = a 3-oxoacyl-[ACP] + H(+) + NADH"}
{"X":22849,"RHEA_ID":30472,"DIRECTION":"LR","MASTER_ID":30471,"metacyc":"RXN-10482","compounds":"(2Z,6Z)-farnesyl diphosphate => (-)-endo-alpha-bergamotene + diphosphate"}
{"X":22850,"RHEA_ID":19915,"compounds":"a 3-oxoacyl-[ACP] + H(+) + NADH => a (3R)-hydroxyacyl-[ACP] + NAD(+)"}
{"X":22851,"RHEA_ID":19921,"DIRECTION":"UN","MASTER_ID":19921,"ec":"1.1.1.137","compounds":"D-ribitol 5-phosphate + NADP(+) = D-ribulose 5-phosphate + H(+) + NADPH"}
{"X":22852,"RHEA_ID":30476,"DIRECTION":"LR","MASTER_ID":30475,"metacyc":"RXN-14111","compounds":"H2O + oroxylin A 7-O-beta-D-glucuronate => D-glucuronate + H(+) + oroxylin A"}
{"X":22853,"RHEA_ID":19922,"compounds":"D-ribitol 5-phosphate + NADP(+) => D-ribulose 5-phosphate + H(+) + NADPH"}
{"X":22854,"RHEA_ID":19923,"DIRECTION":"RL","MASTER_ID":19921,"metacyc":"RIBITOL-5-PHOSPHATE-2-DEHYDROGENASE-RXN","compounds":"D-ribulose 5-phosphate + H(+) + NADPH => D-ribitol 5-phosphate + NADP(+)"}
{"X":22855,"RHEA_ID":19923,"DIRECTION":"RL","MASTER_ID":19921,"metacyc":"RXN-18411","compounds":"D-ribulose 5-phosphate + H(+) + NADPH => D-ribitol 5-phosphate + NADP(+)"}
{"X":22856,"RHEA_ID":40447,"compounds":"(2R)-pristanoyl-CoA = (2S)-pristanoyl-CoA"}
{"X":22857,"RHEA_ID":19925,"DIRECTION":"UN","MASTER_ID":19925,"ec":"1.1.1.137","compounds":"D-ribitol 5-phosphate + NAD(+) = D-ribulose 5-phosphate + H(+) + NADH"}
{"X":22858,"RHEA_ID":19926,"compounds":"D-ribitol 5-phosphate + NAD(+) => D-ribulose 5-phosphate + H(+) + NADH"}
{"X":22859,"RHEA_ID":19927,"DIRECTION":"RL","MASTER_ID":19925,"metacyc":"RIBITOL-5-PHOSPHATE-2-DEHYDROGENASE-RXN","compounds":"D-ribulose 5-phosphate + H(+) + NADH => D-ribitol 5-phosphate + NAD(+)"}
{"X":22860,"RHEA_ID":40451,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphate + H(+)"}
{"X":22861,"RHEA_ID":19929,"DIRECTION":"UN","MASTER_ID":19929,"ec":"2.4.1.12","compounds":"[(1->4)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->4)-beta-D-glucosyl](n+1) + H(+) + UDP"}
{"X":22862,"RHEA_ID":19930,"compounds":"[(1->4)-beta-D-glucosyl](n) + UDP-alpha-D-glucose => [(1->4)-beta-D-glucosyl](n+1) + H(+) + UDP"}
{"X":22863,"RHEA_ID":19931,"compounds":"[(1->4)-beta-D-glucosyl](n+1) + H(+) + UDP => [(1->4)-beta-D-glucosyl](n) + UDP-alpha-D-glucose"}
{"X":22864,"RHEA_ID":40455,"compounds":"(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA = (25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA"}
{"X":22865,"RHEA_ID":19933,"DIRECTION":"UN","MASTER_ID":19933,"ec":"3.1.3.10","compounds":"alpha-D-glucose 1-phosphate + H2O = D-glucose + phosphate"}
{"X":22866,"RHEA_ID":19934,"DIRECTION":"LR","MASTER_ID":19933,"ecocyc":"GLUCOSE-1-PHOSPHAT-RXN","metacyc":"GLUCOSE-1-PHOSPHAT-RXN","compounds":"alpha-D-glucose 1-phosphate + H2O => D-glucose + phosphate"}
{"X":22867,"RHEA_ID":19935,"compounds":"D-glucose + phosphate => alpha-D-glucose 1-phosphate + H2O"}
{"X":22868,"RHEA_ID":30492,"DIRECTION":"LR","MASTER_ID":30491,"metacyc":"RXN-5063","compounds":"L-valine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-valine + oxidized [NADPH--hemoprotein reductase]"}
{"X":22869,"RHEA_ID":19937,"DIRECTION":"UN","MASTER_ID":19937,"ec":"2.1.1.20","compounds":"glycine + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + sarcosine"}
{"X":22870,"RHEA_ID":19938,"DIRECTION":"LR","MASTER_ID":19937,"macie":"M0023","metacyc":"GLYCINE-N-METHYLTRANSFERASE-RXN","reactome":"R-HSA-6798317.1","compounds":"glycine + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + sarcosine"}
{"X":22871,"RHEA_ID":19939,"compounds":"H(+) + S-adenosyl-L-homocysteine + sarcosine => glycine + S-adenosyl-L-methionine"}
{"X":22872,"RHEA_ID":40462,"compounds":"(2S)-pristanoyl-CoA + O2 <=> (2E)-pristenoyl-CoA + H2O2"}
{"X":22873,"RHEA_ID":19941,"DIRECTION":"UN","MASTER_ID":19941,"ec":"2.1.1.128","compounds":"norcoclaurine + S-adenosyl-L-methionine = coclaurine + H(+) + S-adenosyl-L-homocysteine"}
{"X":22874,"RHEA_ID":19942,"compounds":"norcoclaurine + S-adenosyl-L-methionine => coclaurine + H(+) + S-adenosyl-L-homocysteine"}
{"X":22875,"RHEA_ID":19943,"compounds":"coclaurine + H(+) + S-adenosyl-L-homocysteine => norcoclaurine + S-adenosyl-L-methionine"}
{"X":22876,"RHEA_ID":30500,"DIRECTION":"LR","MASTER_ID":30499,"metacyc":"RXN-5065","compounds":"H(+) + N,N-dihydroxy-L-valine => (E)-2-methylpropanal oxime + CO2 + H2O"}
{"X":22877,"RHEA_ID":19945,"DIRECTION":"UN","MASTER_ID":19945,"ec":"2.4.1.201","compounds":"N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP"}
{"X":22878,"RHEA_ID":19946,"DIRECTION":"LR","MASTER_ID":19945,"metacyc":"2.4.1.201-RXN","compounds":"N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP"}
{"X":22879,"RHEA_ID":19947,"compounds":"H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":22880,"RHEA_ID":30504,"compounds":"H2O + N-acetyl-L-glutamate 5-semialdehyde => acetate + L-glutamate 5-semialdehyde"}
{"X":22881,"RHEA_ID":19949,"DIRECTION":"UN","MASTER_ID":19949,"ec":"2.5.1.15","compounds":"(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate"}
{"X":22882,"RHEA_ID":19950,"DIRECTION":"LR","MASTER_ID":19949,"ecocyc":"H2PTEROATESYNTH-RXN","metacyc":"H2PTEROATESYNTH-RXN","compounds":"(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate => 7,8-dihydropteroate + diphosphate"}
{"X":22883,"RHEA_ID":19951,"compounds":"7,8-dihydropteroate + diphosphate => (7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate"}
{"X":22884,"RHEA_ID":40474,"compounds":"(2S)-methylpentadecanoyl-CoA + O2 <=> 2-methyl-(2E)-pentadecenoyl-CoA + H2O2"}
{"X":22885,"RHEA_ID":19953,"DIRECTION":"UN","MASTER_ID":19953,"ec":"2.6.1.12","compounds":"a 2-oxocarboxylate + L-alanine = an L-alpha-amino acid + pyruvate"}
{"X":22886,"RHEA_ID":19954,"compounds":"a 2-oxocarboxylate + L-alanine => an L-alpha-amino acid + pyruvate"}
{"X":22887,"RHEA_ID":19955,"compounds":"an L-alpha-amino acid + pyruvate => a 2-oxocarboxylate + L-alanine"}
{"X":22888,"RHEA_ID":30512,"compounds":"2-demethylmenaquinone-8 + H(+) + NADPH => 2-demethylmenaquinol-8 + NADP(+)"}
{"X":22889,"RHEA_ID":19957,"compounds":"2 5'-dehydroinosine + O2 = 2 9-riburonosylhypoxanthine + 2 H(+)"}
{"X":22890,"RHEA_ID":19958,"DIRECTION":"LR","MASTER_ID":19957,"metacyc":"RXN-7803","compounds":"2 5'-dehydroinosine + O2 => 2 9-riburonosylhypoxanthine + 2 H(+)"}
{"X":22891,"RHEA_ID":19959,"compounds":"2 9-riburonosylhypoxanthine + 2 H(+) => 2 5'-dehydroinosine + O2"}
{"X":22892,"RHEA_ID":30516,"compounds":"S-adenosyl 3-(methylsulfanyl)propylamine + spermidine => H(+) + S-methyl-5'-thioadenosine + thermospermine"}
{"X":22893,"RHEA_ID":19961,"DIRECTION":"UN","MASTER_ID":19961,"ec":"2.7.1.77","compounds":"a 2'-deoxyribonucleoside + a ribonucleoside 5'-phosphate = a 2'-deoxyribonucleoside 5'-phosphate + a ribonucleoside"}
{"X":22894,"RHEA_ID":40484,"compounds":"1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 5-oxopentanoate + H(+)"}
{"X":22895,"RHEA_ID":19963,"compounds":"a 2'-deoxyribonucleoside 5'-phosphate + a ribonucleoside => a 2'-deoxyribonucleoside + a ribonucleoside 5'-phosphate"}
{"X":22896,"RHEA_ID":19965,"DIRECTION":"UN","MASTER_ID":19965,"ec":"4.4.1.3","compounds":"S,S-dimethyl-beta-propiothetin = acrylate + dimethyl sulfide + H(+)"}
{"X":22897,"RHEA_ID":19966,"DIRECTION":"LR","MASTER_ID":19965,"metacyc":"DIMETHYLPROPIOTHETIN-DETHIOMETHYLASE-RXN","compounds":"S,S-dimethyl-beta-propiothetin => acrylate + dimethyl sulfide + H(+)"}
{"X":22898,"RHEA_ID":19967,"compounds":"acrylate + dimethyl sulfide + H(+) => S,S-dimethyl-beta-propiothetin"}
{"X":22899,"RHEA_ID":19969,"DIRECTION":"UN","MASTER_ID":19969,"ec":"1.7.3.6","compounds":"hydroxylamine + O2 = H(+) + H2O + nitrite"}
{"X":22900,"RHEA_ID":30526,"compounds":"GTP + L-glutamate + oxidized coenzyme F420-1 <=> GDP + H(+) + oxidized coenzyme F420-2 + phosphate"}
{"X":22901,"RHEA_ID":19971,"compounds":"H(+) + H2O + nitrite => hydroxylamine + O2"}
{"X":22902,"RHEA_ID":30529,"compounds":"ADP + ATP + 2 H(+) => H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate"}
{"X":22903,"RHEA_ID":19974,"DIRECTION":"LR","MASTER_ID":19973,"metacyc":"SPERMINE-SYNTHASE-RXN","reactome":"R-HSA-351210.1","compounds":"S-adenosyl 3-(methylsulfanyl)propylamine + spermidine => H(+) + S-methyl-5'-thioadenosine + spermine"}
{"X":22904,"RHEA_ID":19975,"compounds":"H(+) + S-methyl-5'-thioadenosine + spermine => S-adenosyl 3-(methylsulfanyl)propylamine + spermidine"}
{"X":22905,"RHEA_ID":30532,"compounds":"biotinate sulfoxide + H(+) + NADH => biotin + H2O + NAD(+)"}
{"X":22906,"RHEA_ID":30533,"compounds":"biotin + H2O + NAD(+) => biotinate sulfoxide + H(+) + NADH"}
{"X":22907,"RHEA_ID":19978,"compounds":"3'-phosphoadenylyl sulfate + L-tyrosine methyl ester => adenosine 3',5'-bisphosphate + H(+) + L-tyrosine methyl ester 4-sulfate"}
{"X":22908,"RHEA_ID":19979,"compounds":"adenosine 3',5'-bisphosphate + H(+) + L-tyrosine methyl ester 4-sulfate => 3'-phosphoadenylyl sulfate + L-tyrosine methyl ester"}
{"X":22909,"RHEA_ID":30536,"compounds":"biotinate sulfoxide + H(+) + NADPH => biotin + H2O + NADP(+)"}
{"X":22910,"RHEA_ID":19981,"DIRECTION":"UN","MASTER_ID":19981,"ec":"1.1.1.284","compounds":"NADP(+) + S-(hydroxymethyl)glutathione = H(+) + NADPH + S-formylglutathione"}
{"X":22911,"RHEA_ID":19982,"DIRECTION":"LR","MASTER_ID":19981,"ecocyc":"RXN-2962","metacyc":"RXN-2962","compounds":"NADP(+) + S-(hydroxymethyl)glutathione => H(+) + NADPH + S-formylglutathione"}
{"X":22912,"RHEA_ID":19983,"compounds":"H(+) + NADPH + S-formylglutathione => NADP(+) + S-(hydroxymethyl)glutathione"}
{"X":22913,"RHEA_ID":30540,"compounds":"(R)-carnitinyl-CoA => (S)-carnitinyl-CoA"}
{"X":22914,"RHEA_ID":30541,"compounds":"(S)-carnitinyl-CoA => (R)-carnitinyl-CoA"}
{"X":22915,"RHEA_ID":19986,"DIRECTION":"LR","MASTER_ID":19985,"ecocyc":"RXN-2962","metacyc":"RXN-2962","reactome":"R-HSA-5692237.1","compounds":"NAD(+) + S-(hydroxymethyl)glutathione => H(+) + NADH + S-formylglutathione"}
{"X":22916,"RHEA_ID":19987,"compounds":"H(+) + NADH + S-formylglutathione => NAD(+) + S-(hydroxymethyl)glutathione"}
{"X":22917,"RHEA_ID":30544,"compounds":"(S)-carnitine + ATP + CoA => (S)-carnitinyl-CoA + ADP + phosphate"}
{"X":22918,"RHEA_ID":19989,"DIRECTION":"UN","MASTER_ID":19989,"ec":"5.3.1.23","compounds":"S-methyl-5-thio-alpha-D-ribose 1-phosphate = 5-methylsulfanyl-D-ribulose 1-phosphate"}
{"X":22919,"RHEA_ID":19990,"DIRECTION":"LR","MASTER_ID":19989,"metacyc":"5.3.1.23-RXN","reactome":"R-HSA-1237096.1","compounds":"S-methyl-5-thio-alpha-D-ribose 1-phosphate => 5-methylsulfanyl-D-ribulose 1-phosphate"}
{"X":22920,"RHEA_ID":19991,"DIRECTION":"RL","MASTER_ID":19989,"reactome":"R-HSA-1299507.1","compounds":"5-methylsulfanyl-D-ribulose 1-phosphate => S-methyl-5-thio-alpha-D-ribose 1-phosphate"}
{"X":22921,"RHEA_ID":30548,"compounds":"(3S)-hydroxyhexanoyl-CoA => (2E)-hexenoyl-CoA + H2O"}
{"X":22922,"RHEA_ID":30549,"DIRECTION":"RL","MASTER_ID":30547,"reactome":"R-HSA-77325.2","compounds":"(2E)-hexenoyl-CoA + H2O => (3S)-hydroxyhexanoyl-CoA"}
{"X":22923,"RHEA_ID":19993,"DIRECTION":"UN","MASTER_ID":19993,"ec":"1.8.4.11","compounds":"[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide"}
{"X":22924,"RHEA_ID":19994,"compounds":"[thioredoxin]-disulfide + H2O + L-methionine => [thioredoxin]-dithiol + L-methionine (S)-S-oxide"}
{"X":22925,"RHEA_ID":19995,"DIRECTION":"RL","MASTER_ID":19993,"ecocyc":"1.8.4.13-RXN","metacyc":"1.8.4.13-RXN","compounds":"[thioredoxin]-dithiol + L-methionine (S)-S-oxide => [thioredoxin]-disulfide + H2O + L-methionine"}
{"X":22926,"RHEA_ID":40520,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":22927,"RHEA_ID":19997,"DIRECTION":"UN","MASTER_ID":19997,"ec":"3.1.3.60","compounds":"H2O + phosphoenolpyruvate = phosphate + pyruvate"}
{"X":22928,"RHEA_ID":19998,"DIRECTION":"LR","MASTER_ID":19997,"ecocyc":"PHOSPHOENOLPYRUVATE-PHOSPHATASE-RXN","metacyc":"PHOSPHOENOLPYRUVATE-PHOSPHATASE-RXN","compounds":"H2O + phosphoenolpyruvate => phosphate + pyruvate"}
{"X":22929,"RHEA_ID":19999,"compounds":"phosphate + pyruvate => H2O + phosphoenolpyruvate"}
{"X":22930,"RHEA_ID":30557,"compounds":"GDP + H(+) + oxidized coenzyme F420-1 + phosphate => GTP + L-glutamate + oxidized F420-0"}
{"X":22931,"RHEA_ID":20001,"DIRECTION":"UN","MASTER_ID":20001,"ec":"1.2.1.21","compounds":"glycolaldehyde + H2O + NAD(+) = glycolate + 2 H(+) + NADH"}
{"X":22932,"RHEA_ID":20002,"DIRECTION":"LR","MASTER_ID":20001,"ecocyc":"GLYCOLALD-DEHYDROG-RXN","metacyc":"GLYCOLALD-DEHYDROG-RXN","compounds":"glycolaldehyde + H2O + NAD(+) => glycolate + 2 H(+) + NADH"}
{"X":22933,"RHEA_ID":20003,"compounds":"glycolate + 2 H(+) + NADH => glycolaldehyde + H2O + NAD(+)"}
{"X":22934,"RHEA_ID":30561,"compounds":"guanosine + H(+) + triphosphate => GTP + H2O"}
{"X":22935,"RHEA_ID":20005,"DIRECTION":"UN","MASTER_ID":20005,"ec":"3.2.1.139","compounds":"an alpha-D-glucuronoside + H2O = an alcohol + D-glucuronate"}
{"X":22936,"RHEA_ID":20006,"DIRECTION":"LR","MASTER_ID":20005,"metacyc":"3.2.1.139-RXN","compounds":"an alpha-D-glucuronoside + H2O => an alcohol + D-glucuronate"}
{"X":22937,"RHEA_ID":20007,"compounds":"an alcohol + D-glucuronate => an alpha-D-glucuronoside + H2O"}
{"X":22938,"RHEA_ID":30565,"compounds":"7-(3-methylbut-2-enyl)-L-tryptophan + diphosphate => dimethylallyl diphosphate + L-tryptophan"}
{"X":22939,"RHEA_ID":20009,"DIRECTION":"UN","MASTER_ID":20009,"ec":"2.4.1.63","compounds":"2-hydroxy-2-methylpropanenitrile + UDP-alpha-D-glucose = H(+) + linamarin + UDP"}
{"X":22940,"RHEA_ID":20010,"DIRECTION":"LR","MASTER_ID":20009,"metacyc":"LINAMARIN-SYNTHASE-RXN","compounds":"2-hydroxy-2-methylpropanenitrile + UDP-alpha-D-glucose => H(+) + linamarin + UDP"}
{"X":22941,"RHEA_ID":20011,"compounds":"H(+) + linamarin + UDP => 2-hydroxy-2-methylpropanenitrile + UDP-alpha-D-glucose"}
{"X":22942,"RHEA_ID":40535,"DIRECTION":"UN","MASTER_ID":40535,"ec":"1.14.15.33","compounds":"4 H(+) + narbomycin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + novapikromycin + 4 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":22943,"RHEA_ID":20013,"DIRECTION":"UN","MASTER_ID":20013,"ec":"2.1.3.2","compounds":"carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate"}
{"X":22944,"RHEA_ID":20014,"DIRECTION":"LR","MASTER_ID":20013,"ecocyc":"ASPCARBTRANS-RXN","reactome":"R-HSA-73573.2","compounds":"carbamoyl phosphate + L-aspartate => H(+) + N-carbamoyl-L-aspartate + phosphate"}
{"X":22945,"RHEA_ID":20015,"compounds":"H(+) + N-carbamoyl-L-aspartate + phosphate => carbamoyl phosphate + L-aspartate"}
{"X":22946,"RHEA_ID":40539,"DIRECTION":"UN","MASTER_ID":40539,"ec":"1.14.15.33","compounds":"10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + methymycin + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":22947,"RHEA_ID":20017,"DIRECTION":"UN","MASTER_ID":20017,"ec":"1.12.98.2","compounds":"5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2 = 5,10-methylenetetrahydromethanopterin + H(+)"}
{"X":22948,"RHEA_ID":20018,"compounds":"5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2 => 5,10-methylenetetrahydromethanopterin + H(+)"}
{"X":22949,"RHEA_ID":20019,"compounds":"5,10-methylenetetrahydromethanopterin + H(+) => 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2"}
{"X":22950,"RHEA_ID":30577,"compounds":"3 menaquinol-8 + protoporphyrin IX => 3 menaquinone-8 + protoporphyrinogen IX"}
{"X":22951,"RHEA_ID":20021,"DIRECTION":"UN","MASTER_ID":20021,"ec":"1.14.11.21","compounds":"2-oxoglutarate + deoxyamidinoproclavaminate + O2 = amidinoproclavaminate + CO2 + succinate"}
{"X":22952,"RHEA_ID":20022,"DIRECTION":"LR","MASTER_ID":20021,"metacyc":"1.14.11.21-RXN","compounds":"2-oxoglutarate + deoxyamidinoproclavaminate + O2 => amidinoproclavaminate + CO2 + succinate"}
{"X":22953,"RHEA_ID":20023,"compounds":"amidinoproclavaminate + CO2 + succinate => 2-oxoglutarate + deoxyamidinoproclavaminate + O2"}
{"X":22954,"RHEA_ID":40547,"DIRECTION":"UN","MASTER_ID":40547,"ec":"1.14.15.33","compounds":"10-deoxymethymycin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + novamethymycin + 4 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":22955,"RHEA_ID":20025,"DIRECTION":"UN","MASTER_ID":20025,"ec":"2.4.1.176","compounds":"gibberellin A3 + UDP-alpha-D-glucose = gibberellin A3 O-beta-D-glucoside + H(+) + UDP"}
{"X":22956,"RHEA_ID":20026,"DIRECTION":"LR","MASTER_ID":20025,"metacyc":"GIBBERELLIN-BETA-GLUCOSYLTRANSFERASE-RXN","compounds":"gibberellin A3 + UDP-alpha-D-glucose => gibberellin A3 O-beta-D-glucoside + H(+) + UDP"}
{"X":22957,"RHEA_ID":20027,"compounds":"gibberellin A3 O-beta-D-glucoside + H(+) + UDP => gibberellin A3 + UDP-alpha-D-glucose"}
{"X":22958,"RHEA_ID":40551,"DIRECTION":"UN","MASTER_ID":40551,"ec":"2.1.1.329","compounds":"demethylphylloquinol + S-adenosyl-L-methionine = H(+) + phylloquinol + S-adenosyl-L-homocysteine"}
{"X":22959,"RHEA_ID":20029,"DIRECTION":"UN","MASTER_ID":20029,"ec":"1.1.1.273","compounds":"10-deoxysarpagine + NADP(+) = H(+) + NADPH + vellosimine"}
{"X":22960,"RHEA_ID":20030,"compounds":"10-deoxysarpagine + NADP(+) => H(+) + NADPH + vellosimine"}
{"X":22961,"RHEA_ID":20031,"DIRECTION":"RL","MASTER_ID":20029,"metacyc":"1.1.1.273-RXN","compounds":"H(+) + NADPH + vellosimine => 10-deoxysarpagine + NADP(+)"}
{"X":22962,"RHEA_ID":40555,"DIRECTION":"UN","MASTER_ID":40555,"ec":"1.14.13.187","compounds":"dTDP-beta-L-evernosamine + H(+) + 2 NADPH + 2 O2 = dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 3 H2O + 2 NADP(+)"}
{"X":22963,"RHEA_ID":20033,"DIRECTION":"UN","MASTER_ID":20033,"ec":"5.1.1.17","compounds":"isopenicillin N = penicillin N"}
{"X":22964,"RHEA_ID":20034,"compounds":"isopenicillin N => penicillin N"}
{"X":22965,"RHEA_ID":20035,"compounds":"penicillin N => isopenicillin N"}
{"X":22966,"RHEA_ID":30592,"DIRECTION":"LR","MASTER_ID":30591,"metacyc":"RXN-5821","reactome":"R-HSA-141202.1","compounds":"H2O + O2 + tyramine => (4-hydroxyphenyl)acetaldehyde + H2O2 + NH4(+)"}
{"X":22967,"RHEA_ID":20037,"DIRECTION":"UN","MASTER_ID":20037,"ec":"1.1.1.200","compounds":"D-sorbitol 6-phosphate + NADP(+) = aldehydo-D-glucose 6-phosphate + H(+) + NADPH"}
{"X":22968,"RHEA_ID":20038,"compounds":"D-sorbitol 6-phosphate + NADP(+) => aldehydo-D-glucose 6-phosphate + H(+) + NADPH"}
{"X":22969,"RHEA_ID":20039,"compounds":"aldehydo-D-glucose 6-phosphate + H(+) + NADPH => D-sorbitol 6-phosphate + NADP(+)"}
{"X":22970,"RHEA_ID":40563,"compounds":"dTDP-N-hydroxy-beta-L-evernosamine + H(+) + NADPH + O2 = dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 2 H2O + NADP(+)"}
{"X":22971,"RHEA_ID":20041,"DIRECTION":"UN","MASTER_ID":20041,"ec":"1.2.1.15","metacyc":"MALONATE-SEMIALDEHYDE-DEHYDROGENASE-RXN","compounds":"3-oxopropanoate + H2O + NADP(+) = 2 H(+) + malonate + NADPH"}
{"X":22972,"RHEA_ID":20042,"compounds":"3-oxopropanoate + H2O + NADP(+) => 2 H(+) + malonate + NADPH"}
{"X":22973,"RHEA_ID":20043,"compounds":"2 H(+) + malonate + NADPH => 3-oxopropanoate + H2O + NADP(+)"}
{"X":22974,"RHEA_ID":30600,"compounds":"15-cis-phytoene + 3 A => 3 AH2 + all-trans-neurosporene"}
{"X":22975,"RHEA_ID":20045,"DIRECTION":"UN","MASTER_ID":20045,"ec":"1.2.1.15","metacyc":"MALONATE-SEMIALDEHYDE-DEHYDROGENASE-RXN","compounds":"3-oxopropanoate + H2O + NAD(+) = 2 H(+) + malonate + NADH"}
{"X":22976,"RHEA_ID":20046,"compounds":"3-oxopropanoate + H2O + NAD(+) => 2 H(+) + malonate + NADH"}
{"X":22977,"RHEA_ID":20047,"compounds":"2 H(+) + malonate + NADH => 3-oxopropanoate + H2O + NAD(+)"}
{"X":22978,"RHEA_ID":30604,"DIRECTION":"LR","MASTER_ID":30603,"metacyc":"RXN-8023","compounds":"15-cis-phytoene + A => AH2 + all-trans-phytofluene"}
{"X":22979,"RHEA_ID":20049,"DIRECTION":"UN","MASTER_ID":20049,"ec":"3.5.4.19","compounds":"1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide"}
{"X":22980,"RHEA_ID":20050,"DIRECTION":"LR","MASTER_ID":20049,"ecocyc":"HISTCYCLOHYD-RXN","metacyc":"HISTCYCLOHYD-RXN","compounds":"1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O => 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide"}
{"X":22981,"RHEA_ID":20051,"compounds":"1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide => 1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O"}
{"X":22982,"RHEA_ID":30608,"DIRECTION":"LR","MASTER_ID":30607,"metacyc":"RXN-8024","compounds":"A + all-trans-phytofluene => AH2 + all-trans-zeta-carotene"}
{"X":22983,"RHEA_ID":20053,"DIRECTION":"UN","MASTER_ID":20053,"ec":"1.1.1.56","compounds":"NAD(+) + ribitol = D-ribulose + H(+) + NADH"}
{"X":22984,"RHEA_ID":20054,"DIRECTION":"LR","MASTER_ID":20053,"metacyc":"RIBITOL-2-DEHYDROGENASE-RXN","compounds":"NAD(+) + ribitol => D-ribulose + H(+) + NADH"}
{"X":22985,"RHEA_ID":20055,"compounds":"D-ribulose + H(+) + NADH => NAD(+) + ribitol"}
{"X":22986,"RHEA_ID":40579,"compounds":"1-O-(1Z)-hexadecenyl-2 (5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+)"}
{"X":22987,"RHEA_ID":20057,"DIRECTION":"UN","MASTER_ID":20057,"ec":"3.5.1.59","compounds":"2 H(+) + H2O + N-carbamoylsarcosine = CO2 + NH4(+) + sarcosine"}
{"X":22988,"RHEA_ID":20058,"DIRECTION":"LR","MASTER_ID":20057,"macie":"M0025","metacyc":"N-CARBAMOYLSARCOSINE-AMIDASE-RXN","compounds":"2 H(+) + H2O + N-carbamoylsarcosine => CO2 + NH4(+) + sarcosine"}
{"X":22989,"RHEA_ID":20059,"compounds":"CO2 + NH4(+) + sarcosine => 2 H(+) + H2O + N-carbamoylsarcosine"}
{"X":22990,"RHEA_ID":30616,"compounds":"15-cis-phytoene + 2 A => 2 AH2 + all-trans-zeta-carotene"}
{"X":22991,"RHEA_ID":20061,"DIRECTION":"UN","MASTER_ID":20061,"ec":"2.7.1.74","compounds":"2'-deoxycytidine + a ribonucleoside 5'-triphosphate = a ribonucleoside 5'-diphosphate + dCMP + H(+)"}
{"X":22992,"RHEA_ID":20062,"DIRECTION":"LR","MASTER_ID":20061,"metacyc":"DEOXYCYTIDINE-KINASE-RXN","compounds":"2'-deoxycytidine + a ribonucleoside 5'-triphosphate => a ribonucleoside 5'-diphosphate + dCMP + H(+)"}
{"X":22993,"RHEA_ID":20063,"compounds":"a ribonucleoside 5'-diphosphate + dCMP + H(+) => 2'-deoxycytidine + a ribonucleoside 5'-triphosphate"}
{"X":22994,"RHEA_ID":40587,"compounds":"H2O + octanedioyl-CoA = CoA + H(+) + octanedioate"}
{"X":22995,"RHEA_ID":20065,"DIRECTION":"UN","MASTER_ID":20065,"ec":"1.14.11.25","compounds":"2'-deoxymugineate + 2-oxoglutarate + O2 = 3-epihydroxy-2'-deoxymugineate + CO2 + H(+) + succinate"}
{"X":22996,"RHEA_ID":20066,"DIRECTION":"LR","MASTER_ID":20065,"metacyc":"RXN-7983","compounds":"2'-deoxymugineate + 2-oxoglutarate + O2 => 3-epihydroxy-2'-deoxymugineate + CO2 + H(+) + succinate"}
{"X":22997,"RHEA_ID":20067,"compounds":"3-epihydroxy-2'-deoxymugineate + CO2 + H(+) + succinate => 2'-deoxymugineate + 2-oxoglutarate + O2"}
{"X":22998,"RHEA_ID":40591,"compounds":"decanedioyl-CoA + H2O = CoA + decanedioate + H(+)"}
{"X":22999,"RHEA_ID":20069,"DIRECTION":"UN","MASTER_ID":20069,"ec":"4.99.1.7","compounds":"(Z)-phenylacetaldehyde oxime = H2O + phenylacetonitrile"}
{"X":23000,"RHEA_ID":20070,"DIRECTION":"LR","MASTER_ID":20069,"metacyc":"4.99.1.7-RXN","compounds":"(Z)-phenylacetaldehyde oxime => H2O + phenylacetonitrile"}
{"X":23001,"RHEA_ID":20071,"compounds":"H2O + phenylacetonitrile => (Z)-phenylacetaldehyde oxime"}
{"X":23002,"RHEA_ID":40595,"compounds":"dodecanedioyl-CoA + H2O = CoA + dodecanedioate + H(+)"}
{"X":23003,"RHEA_ID":20073,"DIRECTION":"UN","MASTER_ID":20073,"ec":"4.1.2.42","compounds":"D-allothreonine = acetaldehyde + glycine"}
{"X":23004,"RHEA_ID":20074,"compounds":"D-allothreonine => acetaldehyde + glycine"}
{"X":23005,"RHEA_ID":20075,"compounds":"acetaldehyde + glycine => D-allothreonine"}
{"X":23006,"RHEA_ID":40599,"compounds":"1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + H2O = a 2-acyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate"}
{"X":23007,"RHEA_ID":20077,"DIRECTION":"UN","MASTER_ID":20077,"ec":"2.1.1.34","compounds":"guanosine(18) in tRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(18) in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":23008,"RHEA_ID":20078,"DIRECTION":"LR","MASTER_ID":20077,"ecocyc":"2.1.1.34-RXN","metacyc":"2.1.1.34-RXN","compounds":"guanosine(18) in tRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine(18) in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":23009,"RHEA_ID":20079,"compounds":"2'-O-methylguanosine(18) in tRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(18) in tRNA + S-adenosyl-L-methionine"}
{"X":23010,"RHEA_ID":50574,"compounds":"CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-valyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-valyl-[protein]"}
{"X":23011,"RHEA_ID":20081,"DIRECTION":"UN","MASTER_ID":20081,"ec":"3.5.1.39","metacyc":"ALKYLAMIDASE-RXN","compounds":"H2O + N-methylhexanamide = hexanoate + methylamine"}
{"X":23012,"RHEA_ID":20082,"compounds":"H2O + N-methylhexanamide => hexanoate + methylamine"}
{"X":23013,"RHEA_ID":20083,"compounds":"hexanoate + methylamine => H2O + N-methylhexanamide"}
{"X":23014,"RHEA_ID":20085,"DIRECTION":"UN","MASTER_ID":20085,"ec":"2.3.1.116","compounds":"a flavonol 3-O-beta-D-glucoside + malonyl-CoA = a flavonol 3-O-(6-O-malonyl-beta-D-glucoside) + CoA"}
{"X":23015,"RHEA_ID":20086,"DIRECTION":"LR","MASTER_ID":20085,"metacyc":"2.3.1.116-RXN","compounds":"a flavonol 3-O-beta-D-glucoside + malonyl-CoA => a flavonol 3-O-(6-O-malonyl-beta-D-glucoside) + CoA"}
{"X":23016,"RHEA_ID":20087,"compounds":"a flavonol 3-O-(6-O-malonyl-beta-D-glucoside) + CoA => a flavonol 3-O-beta-D-glucoside + malonyl-CoA"}
{"X":23017,"RHEA_ID":50582,"compounds":"CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-lysyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-lysyl-[protein]"}
{"X":23018,"RHEA_ID":20089,"DIRECTION":"UN","MASTER_ID":20089,"ec":"2.3.1.66","metacyc":"LEUCINE-N-ACETYLTRANSFERASE-RXN","compounds":"acetyl-CoA + L-leucine = CoA + H(+) + N-acetyl-L-leucine"}
{"X":23019,"RHEA_ID":20090,"compounds":"acetyl-CoA + L-leucine => CoA + H(+) + N-acetyl-L-leucine"}
{"X":23020,"RHEA_ID":20091,"compounds":"CoA + H(+) + N-acetyl-L-leucine => acetyl-CoA + L-leucine"}
{"X":23021,"RHEA_ID":40615,"compounds":"H2O + tridecanoylglycerol = 2,3-didecanoyl-sn-glycerol + decanoate + H(+)"}
{"X":23022,"RHEA_ID":30647,"DIRECTION":"UN","MASTER_ID":30647,"ec":"2.7.7.74","compounds":"1D-myo-inositol 3-phosphate + CTP + H(+) = CDP-1L-myo-inositol + diphosphate"}
{"X":23023,"RHEA_ID":20094,"DIRECTION":"LR","MASTER_ID":20093,"metacyc":"2.4.1.115-RXN","compounds":"an anthocyanidin + H(+) + UDP-alpha-D-glucose => an anthocyanidin 3-O-beta-D-glucoside + UDP"}
{"X":23024,"RHEA_ID":20095,"compounds":"an anthocyanidin 3-O-beta-D-glucoside + UDP => an anthocyanidin + H(+) + UDP-alpha-D-glucose"}
{"X":23025,"RHEA_ID":40619,"compounds":"H2O + tridodecanoylglycerol = 2,3-didodecanoyl-sn-glycerol + dodecanoate + H(+)"}
{"X":23026,"RHEA_ID":30651,"compounds":"2 H2O + O2 + urate = allantoin + CO2 + H2O2"}
{"X":23027,"RHEA_ID":20098,"DIRECTION":"LR","MASTER_ID":20097,"ecocyc":"MANNONDEHYDRAT-RXN","metacyc":"MANNONDEHYDRAT-RXN","compounds":"D-mannonate => 2-dehydro-3-deoxy-D-gluconate + H2O"}
{"X":23028,"RHEA_ID":20099,"compounds":"2-dehydro-3-deoxy-D-gluconate + H2O => D-mannonate"}
{"X":23029,"RHEA_ID":30654,"DIRECTION":"BI","MASTER_ID":30651,"metacyc":"RXN0-5473","compounds":"2 H2O + O2 + urate <=> allantoin + CO2 + H2O2"}
{"X":23030,"RHEA_ID":20101,"DIRECTION":"UN","MASTER_ID":20101,"ec":"6.2.1.19","compounds":"a long-chain fatty acid + ATP + L-cysteinyl-[protein] = AMP + diphosphate + S-(long-chain fatty acyl)-L-cysteinyl-[protein]"}
{"X":23031,"RHEA_ID":20102,"DIRECTION":"LR","MASTER_ID":20101,"metacyc":"6.2.1.19-RXN","compounds":"a long-chain fatty acid + ATP + L-cysteinyl-[protein] => AMP + diphosphate + S-(long-chain fatty acyl)-L-cysteinyl-[protein]"}
{"X":23032,"RHEA_ID":20103,"compounds":"AMP + diphosphate + S-(long-chain fatty acyl)-L-cysteinyl-[protein] => a long-chain fatty acid + ATP + L-cysteinyl-[protein]"}
{"X":23033,"RHEA_ID":40627,"compounds":"H2O + trihexadecanoylglycerol = 2,3-dihexadecanoyl-sn-glycerol + H(+) + hexadecanoate"}
{"X":23034,"RHEA_ID":20105,"DIRECTION":"UN","MASTER_ID":20105,"ec":"2.7.1.146","compounds":"ADP + beta-D-fructose 6-phosphate = AMP + beta-D-fructose 1,6-bisphosphate + H(+)"}
{"X":23035,"RHEA_ID":20106,"compounds":"ADP + beta-D-fructose 6-phosphate => AMP + beta-D-fructose 1,6-bisphosphate + H(+)"}
{"X":23036,"RHEA_ID":20107,"compounds":"AMP + beta-D-fructose 1,6-bisphosphate + H(+) => ADP + beta-D-fructose 6-phosphate"}
{"X":23037,"RHEA_ID":40631,"compounds":"H2O + trioctadecanoylglycerol = 2,3-dioctadecanoyl-sn-glycerol + H(+) + octadecanoate"}
{"X":23038,"RHEA_ID":30663,"DIRECTION":"UN","MASTER_ID":30663,"ec":"5.5.1.31","compounds":"3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole = hapalindole H"}
{"X":23039,"RHEA_ID":20110,"DIRECTION":"LR","MASTER_ID":20109,"metacyc":"RXN0-1401","compounds":"alpha-D-ribose 1,5-bisphosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate + ADP"}
{"X":23040,"RHEA_ID":20111,"compounds":"5-phospho-alpha-D-ribose 1-diphosphate + ADP => alpha-D-ribose 1,5-bisphosphate + ATP"}
{"X":23041,"RHEA_ID":40635,"compounds":"1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O = 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+) + hexadecanoate"}
{"X":23042,"RHEA_ID":30667,"compounds":"germacra-1(10),4,11(13)-trien-12-ol + H2O + 2 NADP(+) = germacra-1(10),4,11(13)-trien-12-oate + 3 H(+) + 2 NADPH"}
{"X":23043,"RHEA_ID":20114,"DIRECTION":"LR","MASTER_ID":20113,"macie":"M0206","compounds":"beta-D-glucose 1-phosphate => beta-D-glucose 6-phosphate"}
{"X":23044,"RHEA_ID":20115,"compounds":"beta-D-glucose 6-phosphate => beta-D-glucose 1-phosphate"}
{"X":23045,"RHEA_ID":40639,"compounds":"1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H2O = (9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+)"}
{"X":23046,"RHEA_ID":30671,"compounds":"H2O + N,N'-diacetylchitobiose = 2 N-acetyl-D-glucosamine"}
{"X":23047,"RHEA_ID":20118,"DIRECTION":"LR","MASTER_ID":20117,"ecocyc":"RHAMNULOKIN-RXN","metacyc":"RHAMNULOKIN-RXN","compounds":"ATP + L-rhamnulose => ADP + H(+) + L-rhamnulose 1-phosphate"}
{"X":23048,"RHEA_ID":20119,"compounds":"ADP + H(+) + L-rhamnulose 1-phosphate => ATP + L-rhamnulose"}
{"X":23049,"RHEA_ID":40643,"compounds":"1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":23050,"RHEA_ID":30675,"DIRECTION":"UN","MASTER_ID":30675,"ec":"4.2.1.123","compounds":"tetrahymanol = H2O + squalene"}
{"X":23051,"RHEA_ID":20122,"DIRECTION":"LR","MASTER_ID":20121,"ecocyc":"GLUTAMINE--TRNA-LIGASE-RXN","metacyc":"GLUTAMINE--TRNA-LIGASE-RXN","compounds":"ATP + L-glutamine + tRNA(Gln) => AMP + diphosphate + L-glutaminyl-tRNA(Gln)"}
{"X":23052,"RHEA_ID":20123,"compounds":"AMP + diphosphate + L-glutaminyl-tRNA(Gln) => ATP + L-glutamine + tRNA(Gln)"}
{"X":23053,"RHEA_ID":40647,"compounds":"1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+)"}
{"X":23054,"RHEA_ID":30679,"compounds":"D-cellobiose + H2O = 2 beta-D-glucose"}
{"X":23055,"RHEA_ID":20125,"DIRECTION":"UN","MASTER_ID":20125,"ec":"1.18.1.2","compounds":"H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":23056,"RHEA_ID":20126,"DIRECTION":"LR","MASTER_ID":20125,"metacyc":"1.18.1.2-RXN","compounds":"H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] => NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":23057,"RHEA_ID":20127,"compounds":"NADPH + 2 oxidized [2Fe-2S]-[ferredoxin] => H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":23058,"RHEA_ID":30683,"DIRECTION":"UN","MASTER_ID":30683,"ec":"3.2.1.183","compounds":"H2O + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N-acetyl-D-mannosamine + UDP"}
{"X":23059,"RHEA_ID":20129,"DIRECTION":"UN","MASTER_ID":20129,"ec":"3.2.2.4","compounds":"AMP + H2O = adenine + D-ribose 5-phosphate"}
{"X":23060,"RHEA_ID":20130,"DIRECTION":"LR","MASTER_ID":20129,"ecocyc":"AMP-NUCLEOSID-RXN","metacyc":"AMP-NUCLEOSID-RXN","compounds":"AMP + H2O => adenine + D-ribose 5-phosphate"}
{"X":23061,"RHEA_ID":20131,"compounds":"adenine + D-ribose 5-phosphate => AMP + H2O"}
{"X":23062,"RHEA_ID":40656,"compounds":"(R)-malate + succinyl-CoA => (R)-malyl-CoA + succinate"}
{"X":23063,"RHEA_ID":20133,"DIRECTION":"UN","MASTER_ID":20133,"ec":"1.1.1.110","compounds":"3-(indol-3-yl)lactate + NAD(+) = H(+) + indole-3-pyruvate + NADH"}
{"X":23064,"RHEA_ID":20134,"compounds":"3-(indol-3-yl)lactate + NAD(+) => H(+) + indole-3-pyruvate + NADH"}
{"X":23065,"RHEA_ID":20135,"compounds":"H(+) + indole-3-pyruvate + NADH => 3-(indol-3-yl)lactate + NAD(+)"}
{"X":23066,"RHEA_ID":30691,"compounds":"H2O2 + methanol = formaldehyde + 2 H2O"}
{"X":23067,"RHEA_ID":20137,"DIRECTION":"UN","MASTER_ID":20137,"ec":"2.3.1.167","compounds":"10-deacetylbaccatin III + acetyl-CoA = baccatin III + CoA"}
{"X":23068,"RHEA_ID":20138,"DIRECTION":"LR","MASTER_ID":20137,"metacyc":"2.3.1.167-RXN","compounds":"10-deacetylbaccatin III + acetyl-CoA => baccatin III + CoA"}
{"X":23069,"RHEA_ID":20139,"compounds":"baccatin III + CoA => 10-deacetylbaccatin III + acetyl-CoA"}
{"X":23070,"RHEA_ID":30695,"compounds":"3-aminopropanal + H2O + NAD(+) = beta-alanine + 2 H(+) + NADH"}
{"X":23071,"RHEA_ID":30696,"compounds":"3-aminopropanal + H2O + NAD(+) => beta-alanine + 2 H(+) + NADH"}
{"X":23072,"RHEA_ID":20142,"compounds":"an S-alkyl-L-cysteine S-oxide => 2-aminoprop-2-enoate + an S-alkyl sulfenate"}
{"X":23073,"RHEA_ID":20143,"compounds":"2-aminoprop-2-enoate + an S-alkyl sulfenate => an S-alkyl-L-cysteine S-oxide"}
{"X":23074,"RHEA_ID":20145,"compounds":"2-(3-amino-3-carboxypropyl)-L-histidine + S-adenosyl-L-methionine = 2-[3-carboxy-3-(methylammonio)propyl]-L-histidine + H(+) + S-adenosyl-L-homocysteine"}
{"X":23075,"RHEA_ID":30701,"compounds":"3-oxopropanoate + L-glutamate => 2-oxoglutarate + beta-alanine"}
{"X":23076,"RHEA_ID":40671,"DIRECTION":"UN","MASTER_ID":40671,"ec":"3.5.99.10","compounds":"2-iminopropanoate + H2O = NH4(+) + pyruvate"}
{"X":23077,"RHEA_ID":20148,"compounds":"2-(3-amino-3-carboxypropyl)-L-histidine + S-adenosyl-L-methionine <=> 2-[3-carboxy-3-(methylammonio)propyl]-L-histidine + H(+) + S-adenosyl-L-homocysteine"}
{"X":23078,"RHEA_ID":20149,"DIRECTION":"UN","MASTER_ID":20149,"ec":"1.14.14.55","compounds":"O2 + quinine + reduced [NADPH--hemoprotein reductase] = 3-hydroxyquinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":23079,"RHEA_ID":20150,"DIRECTION":"LR","MASTER_ID":20149,"metacyc":"1.14.13.67-RXN","compounds":"O2 + quinine + reduced [NADPH--hemoprotein reductase] => 3-hydroxyquinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":23080,"RHEA_ID":20151,"compounds":"3-hydroxyquinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + quinine + reduced [NADPH--hemoprotein reductase]"}
{"X":23081,"RHEA_ID":30707,"DIRECTION":"UN","MASTER_ID":30707,"ec":"2.6.1.113","compounds":"putrescine + pyruvate = 4-aminobutanal + L-alanine"}
{"X":23082,"RHEA_ID":20153,"DIRECTION":"UN","MASTER_ID":20153,"ec":"2.7.1.46","compounds":"ATP + L-arabinose = ADP + beta-L-arabinose 1-phosphate + H(+)"}
{"X":23083,"RHEA_ID":20154,"DIRECTION":"LR","MASTER_ID":20153,"metacyc":"L-ARABINOKINASE-RXN","compounds":"ATP + L-arabinose => ADP + beta-L-arabinose 1-phosphate + H(+)"}
{"X":23084,"RHEA_ID":30711,"DIRECTION":"UN","MASTER_ID":30711,"ec":"4.2.1.127","compounds":"(S)-linalool = beta-myrcene + H2O"}
{"X":23085,"RHEA_ID":20157,"DIRECTION":"UN","MASTER_ID":20157,"ec":"1.1.2.6","compounds":"2n [Fe(III)cytochrome c] + a polyvinyl alcohol = 2n [Fe(II)cytochrome c] + an oxidized polyvinyl alcohol + 2n H(+)"}
{"X":23086,"RHEA_ID":20158,"DIRECTION":"LR","MASTER_ID":20157,"metacyc":"RXN-11316","compounds":"2n [Fe(III)cytochrome c] + a polyvinyl alcohol => 2n [Fe(II)cytochrome c] + an oxidized polyvinyl alcohol + 2n H(+)"}
{"X":23087,"RHEA_ID":40683,"compounds":"1-hexadecanoylglycerone 3-phosphate + dodecan-1-ol = 1-O-dodecylglycerone 3-phosphate + H(+) + hexadecanoate"}
{"X":23088,"RHEA_ID":20161,"DIRECTION":"UN","MASTER_ID":20161,"ec":"2.4.1.82","compounds":"alpha-D-galactosyl-(1->3)-1D-myo-inositol + sucrose = myo-inositol + raffinose"}
{"X":23089,"RHEA_ID":20162,"DIRECTION":"LR","MASTER_ID":20161,"metacyc":"2.4.1.82-RXN","compounds":"alpha-D-galactosyl-(1->3)-1D-myo-inositol + sucrose => myo-inositol + raffinose"}
{"X":23090,"RHEA_ID":40687,"compounds":"1-hexadecanoylglycerone 3-phosphate + tetradecan-1-ol = 1-O-tetradecylglycerone 3-phosphate + H(+) + hexadecanoate"}
{"X":23091,"RHEA_ID":30719,"compounds":"acetyl-CoA + propanoyl-CoA = 2-methyl-3-oxobutanoyl-CoA + CoA"}
{"X":23092,"RHEA_ID":20165,"DIRECTION":"UN","MASTER_ID":20165,"ec":"3.1.1.48","compounds":"H2O + N(5)-acyl-L-ornithine ester = an alcohol + H(+) + N(5)-acyl-L-ornithine"}
{"X":23093,"RHEA_ID":20166,"DIRECTION":"LR","MASTER_ID":20165,"metacyc":"FUSARININE-C-ORNITHINESTERASE-RXN","compounds":"H2O + N(5)-acyl-L-ornithine ester => an alcohol + H(+) + N(5)-acyl-L-ornithine"}
{"X":23094,"RHEA_ID":20167,"compounds":"an alcohol + H(+) + N(5)-acyl-L-ornithine => H2O + N(5)-acyl-L-ornithine ester"}
{"X":23095,"RHEA_ID":20169,"compounds":"H(+) + NADPH + O2 + tetradecanoyl-CoA = (11E)-tetradecenoyl-CoA + 2 H2O + NADP(+)"}
{"X":23096,"RHEA_ID":20170,"compounds":"H(+) + NADPH + O2 + tetradecanoyl-CoA => (11E)-tetradecenoyl-CoA + 2 H2O + NADP(+)"}
{"X":23097,"RHEA_ID":20171,"compounds":"(11E)-tetradecenoyl-CoA + 2 H2O + NADP(+) => H(+) + NADPH + O2 + tetradecanoyl-CoA"}
{"X":23098,"RHEA_ID":30727,"DIRECTION":"UN","MASTER_ID":30727,"ec":"2.7.1.40","compounds":"dATP + pyruvate = dADP + H(+) + phosphoenolpyruvate"}
{"X":23099,"RHEA_ID":20173,"compounds":"H(+) + NADH + O2 + tetradecanoyl-CoA = (11E)-tetradecenoyl-CoA + 2 H2O + NAD(+)"}
{"X":23100,"RHEA_ID":20174,"compounds":"H(+) + NADH + O2 + tetradecanoyl-CoA => (11E)-tetradecenoyl-CoA + 2 H2O + NAD(+)"}
{"X":23101,"RHEA_ID":20175,"compounds":"(11E)-tetradecenoyl-CoA + 2 H2O + NAD(+) => H(+) + NADH + O2 + tetradecanoyl-CoA"}
{"X":23102,"RHEA_ID":30731,"compounds":"butanoyl-CoA + FAD + H(+) = (2E)-butenoyl-CoA + FADH2"}
{"X":23103,"RHEA_ID":20177,"DIRECTION":"UN","MASTER_ID":20177,"ec":"2.4.1.160","compounds":"pyridoxine + UDP-alpha-D-glucose = 5'-O-beta-D-glucosylpyridoxine + H(+) + UDP"}
{"X":23104,"RHEA_ID":20178,"DIRECTION":"LR","MASTER_ID":20177,"metacyc":"2.4.1.160-RXN","compounds":"pyridoxine + UDP-alpha-D-glucose => 5'-O-beta-D-glucosylpyridoxine + H(+) + UDP"}
{"X":23105,"RHEA_ID":40703,"compounds":"(9Z,12Z)-octadecadien-1-ol + 1-hexadecanoylglycerone 3-phosphate = 1-O-(9Z,12Z)-octadecadienylglycerone 3-phosphate + H(+) + hexadecanoate"}
{"X":23106,"RHEA_ID":30735,"DIRECTION":"UN","MASTER_ID":30735,"ec":"3.1.3.25","compounds":"1D-myo-inositol 4-phosphate + H2O = myo-inositol + phosphate"}
{"X":23107,"RHEA_ID":20181,"DIRECTION":"UN","MASTER_ID":20181,"ec":"2.7.8.19","compounds":"alpha-D-mannose derivative + UDP-alpha-D-glucose = 6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H(+) + UMP"}
{"X":23108,"RHEA_ID":20182,"DIRECTION":"LR","MASTER_ID":20181,"metacyc":"2.7.8.19-RXN","compounds":"alpha-D-mannose derivative + UDP-alpha-D-glucose => 6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H(+) + UMP"}
{"X":23109,"RHEA_ID":40707,"compounds":"(9Z,12Z,15Z)-octadecatrien-1-ol + 1-hexadecanoylglycerone 3-phosphate = 1-O-(9Z,12Z,15Z)-octadecatrienylglycerone 3-phosphate + H(+) + hexadecanoate"}
{"X":23110,"RHEA_ID":30739,"DIRECTION":"UN","MASTER_ID":30739,"ec":"3.1.3.25","compounds":"1D-myo-inositol 3-phosphate + H2O = myo-inositol + phosphate"}
{"X":23111,"RHEA_ID":20185,"DIRECTION":"UN","MASTER_ID":20185,"ec":"3.1.4.40","compounds":"a CMP-N-acyl-beta-neuraminate + H2O = an N-acylneuraminate + CMP + H(+)"}
{"X":23112,"RHEA_ID":20186,"DIRECTION":"LR","MASTER_ID":20185,"metacyc":"3.1.4.40-RXN","compounds":"a CMP-N-acyl-beta-neuraminate + H2O => an N-acylneuraminate + CMP + H(+)"}
{"X":23113,"RHEA_ID":20187,"compounds":"an N-acylneuraminate + CMP + H(+) => a CMP-N-acyl-beta-neuraminate + H2O"}
{"X":23114,"RHEA_ID":20189,"DIRECTION":"UN","MASTER_ID":20189,"ec":"1.3.1.1","compounds":"5,6-dihydrouracil + NAD(+) = H(+) + NADH + uracil"}
{"X":23115,"RHEA_ID":20190,"compounds":"5,6-dihydrouracil + NAD(+) => H(+) + NADH + uracil"}
{"X":23116,"RHEA_ID":20191,"compounds":"H(+) + NADH + uracil => 5,6-dihydrouracil + NAD(+)"}
{"X":23117,"RHEA_ID":40716,"DIRECTION":"LR","MASTER_ID":40715,"reactome":"R-HSA-75879.2","compounds":"dihydroxyacetone phosphate + hexadecanoyl-CoA => 1-hexadecanoylglycerone 3-phosphate + CoA"}
{"X":23118,"RHEA_ID":20193,"DIRECTION":"UN","MASTER_ID":20193,"ec":"1.1.1.33","compounds":"(R)-mevalonate + NADP(+) = H(+) + mevaldate + NADPH"}
{"X":23119,"RHEA_ID":20194,"DIRECTION":"LR","MASTER_ID":20193,"metacyc":"MEVALDATE-REDUCTASE-NADPH-RXN","compounds":"(R)-mevalonate + NADP(+) => H(+) + mevaldate + NADPH"}
{"X":23120,"RHEA_ID":20195,"compounds":"H(+) + mevaldate + NADPH => (R)-mevalonate + NADP(+)"}
{"X":23121,"RHEA_ID":30751,"compounds":"ATP + CoA + hexadecanoate = AMP + diphosphate + hexadecanoyl-CoA"}
{"X":23122,"RHEA_ID":20197,"DIRECTION":"UN","MASTER_ID":20197,"ec":"5.1.3.17","compounds":"[heparosan-N-sulfate](n) = [heparan-N-sulfate](n)"}
{"X":23123,"RHEA_ID":20198,"compounds":"[heparosan-N-sulfate](n) => [heparan-N-sulfate](n)"}
{"X":23124,"RHEA_ID":20199,"compounds":"[heparan-N-sulfate](n) => [heparosan-N-sulfate](n)"}
{"X":23125,"RHEA_ID":40724,"compounds":"(9E)-octadecenoyl-CoA + H2O => (9E)-octadecenoate + CoA + H(+)"}
{"X":23126,"RHEA_ID":20201,"DIRECTION":"UN","MASTER_ID":20201,"ec":"5.1.1.11","compounds":"ATP + H2O + L-phenylalanine = AMP + D-phenylalanine + diphosphate + H(+)"}
{"X":23127,"RHEA_ID":20202,"compounds":"ATP + H2O + L-phenylalanine => AMP + D-phenylalanine + diphosphate + H(+)"}
{"X":23128,"RHEA_ID":20203,"compounds":"AMP + D-phenylalanine + diphosphate + H(+) => ATP + H2O + L-phenylalanine"}
{"X":23129,"RHEA_ID":60892,"compounds":"a 5'-end NAD(+)-phospho-ribonucleoside in snoRNA + H2O = a 5'-end phospho-ribonucleoside in snoRNA + H(+) + NAD(+)"}
{"X":23130,"RHEA_ID":20205,"DIRECTION":"UN","MASTER_ID":20205,"ec":"2.4.1.171","compounds":"methylazoxymethanol + UDP-alpha-D-glucose = cycasin + H(+) + UDP"}
{"X":23131,"RHEA_ID":20206,"DIRECTION":"LR","MASTER_ID":20205,"metacyc":"2.4.1.171-RXN","compounds":"methylazoxymethanol + UDP-alpha-D-glucose => cycasin + H(+) + UDP"}
{"X":23132,"RHEA_ID":20207,"compounds":"cycasin + H(+) + UDP => methylazoxymethanol + UDP-alpha-D-glucose"}
{"X":23133,"RHEA_ID":20209,"DIRECTION":"UN","MASTER_ID":20209,"ec":"2.7.1.122","metacyc":"XYLITOL-KINASE-RXN","compounds":"ATP + xylitol = ADP + H(+) + xylitol 5-phosphate"}
{"X":23134,"RHEA_ID":20210,"compounds":"ATP + xylitol => ADP + H(+) + xylitol 5-phosphate"}
{"X":23135,"RHEA_ID":20211,"compounds":"ADP + H(+) + xylitol 5-phosphate => ATP + xylitol"}
{"X":23136,"RHEA_ID":50711,"compounds":"(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione <=> (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O"}
{"X":23137,"RHEA_ID":20213,"DIRECTION":"UN","MASTER_ID":20213,"ec":"2.3.1.204","compounds":"[glycine-cleavage complex H protein]-N(6)-octanoyl-L-lysine + [lipoyl-carrier protein]-L-lysine = [glycine-cleavage complex H protein]-L-lysine + [lipoyl-carrier protein]-N(6)-octanoyl-L-lysine"}
{"X":23138,"RHEA_ID":20214,"DIRECTION":"LR","MASTER_ID":20213,"metacyc":"RXN-13036","compounds":"[glycine-cleavage complex H protein]-N(6)-octanoyl-L-lysine + [lipoyl-carrier protein]-L-lysine => [glycine-cleavage complex H protein]-L-lysine + [lipoyl-carrier protein]-N(6)-octanoyl-L-lysine"}
{"X":23139,"RHEA_ID":20215,"compounds":"[glycine-cleavage complex H protein]-L-lysine + [lipoyl-carrier protein]-N(6)-octanoyl-L-lysine => [glycine-cleavage complex H protein]-N(6)-octanoyl-L-lysine + [lipoyl-carrier protein]-L-lysine"}
{"X":23140,"RHEA_ID":40740,"DIRECTION":"LR","MASTER_ID":40739,"metacyc":"RXN-14600","compounds":"(20S)-ginsenoside Rb2 + 2 H2O => (20S)-ginsenoside C-Y + 2 D-glucose"}
{"X":23141,"RHEA_ID":20217,"DIRECTION":"UN","MASTER_ID":20217,"ec":"4.1.2.32","compounds":"H(+) + trimethylamine N-oxide = dimethylamine + formaldehyde"}
{"X":23142,"RHEA_ID":20218,"DIRECTION":"LR","MASTER_ID":20217,"metacyc":"TRIMETHYLAMINE-OXIDE-ALDOLASE-RXN","compounds":"H(+) + trimethylamine N-oxide => dimethylamine + formaldehyde"}
{"X":23143,"RHEA_ID":20219,"compounds":"dimethylamine + formaldehyde => H(+) + trimethylamine N-oxide"}
{"X":23144,"RHEA_ID":20221,"DIRECTION":"UN","MASTER_ID":20221,"ec":"6.3.4.3","compounds":"(6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6S)-10-formyltetrahydrofolate + ADP + phosphate"}
{"X":23145,"RHEA_ID":20222,"DIRECTION":"LR","MASTER_ID":20221,"ecocyc":"FORMATETHFLIG-RXN","reactome":"R-HSA-5696839.2","compounds":"(6S)-5,6,7,8-tetrahydrofolate + ATP + formate => (6S)-10-formyltetrahydrofolate + ADP + phosphate"}
{"X":23146,"RHEA_ID":20223,"DIRECTION":"RL","MASTER_ID":20221,"reactome":"R-HSA-6801456.1","compounds":"(6S)-10-formyltetrahydrofolate + ADP + phosphate => (6S)-5,6,7,8-tetrahydrofolate + ATP + formate"}
{"X":23147,"RHEA_ID":50723,"compounds":"FMNH2 + methanesulfinate + O2 <=> FMN + H(+) + H2O + methanesulfonate"}
{"X":23148,"RHEA_ID":20225,"DIRECTION":"UN","MASTER_ID":20225,"ec":"2.1.1.68","compounds":"(E)-caffeate + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + trans-ferulate"}
{"X":23149,"RHEA_ID":20226,"DIRECTION":"LR","MASTER_ID":20225,"metacyc":"RXN-1104","compounds":"(E)-caffeate + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + trans-ferulate"}
{"X":23150,"RHEA_ID":20227,"compounds":"H(+) + S-adenosyl-L-homocysteine + trans-ferulate => (E)-caffeate + S-adenosyl-L-methionine"}
{"X":23151,"RHEA_ID":40752,"compounds":"(9Z)-octadecenoate + 1-hexadecanoylglycerone 3-phosphate => 1-(9Z)-octadecenoylglycerone 3-phosphate + hexadecanoate"}
{"X":23152,"RHEA_ID":30783,"compounds":"D-glyceraldehyde + H2O + NAD(+) = (R)-glycerate + 2 H(+) + NADH"}
{"X":23153,"RHEA_ID":20230,"DIRECTION":"LR","MASTER_ID":20229,"ecocyc":"DHBAMPLIG-RXN","metacyc":"DHBAMPLIG-RXN","compounds":"2,3-dihydroxybenzoate + ATP + H(+) => 2,3-dihydroxybenzoyl-5'-AMP + diphosphate"}
{"X":23154,"RHEA_ID":20231,"compounds":"2,3-dihydroxybenzoyl-5'-AMP + diphosphate => 2,3-dihydroxybenzoate + ATP + H(+)"}
{"X":23155,"RHEA_ID":40756,"compounds":"(9Z,12Z)-octadecadienoate + 1-hexadecanoylglycerone 3-phosphate => 1-(9Z,12Z)-octadecadienoylglycerone 3-phosphate + hexadecanoate"}
{"X":23156,"RHEA_ID":30787,"compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (6R)-L-erythro-6,7-dihydrobiopterin + H2O + L-tyrosine"}
{"X":23157,"RHEA_ID":20234,"compounds":"a 7beta-hydroxysteroid + NADP(+) => a 7-oxosteroid + H(+) + NADPH"}
{"X":23158,"RHEA_ID":20235,"compounds":"a 7-oxosteroid + H(+) + NADPH => a 7beta-hydroxysteroid + NADP(+)"}
{"X":23159,"RHEA_ID":40760,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoylglycerone 3-phosphate => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerone 3-phosphate + hexadecanoate"}
{"X":23160,"RHEA_ID":20237,"compounds":"(1S,4S)-5-oxo-1,2-campholide = [(1R)-2,2,3-trimethyl-2-oxocyclopent-3-en-1-yl]acetate + H(+)"}
{"X":23161,"RHEA_ID":20238,"DIRECTION":"LR","MASTER_ID":20237,"metacyc":"RXN-13044","compounds":"(1S,4S)-5-oxo-1,2-campholide => [(1R)-2,2,3-trimethyl-2-oxocyclopent-3-en-1-yl]acetate + H(+)"}
{"X":23162,"RHEA_ID":20239,"compounds":"[(1R)-2,2,3-trimethyl-2-oxocyclopent-3-en-1-yl]acetate + H(+) => (1S,4S)-5-oxo-1,2-campholide"}
{"X":23163,"RHEA_ID":20240,"compounds":"(1S,4S)-5-oxo-1,2-campholide <=> [(1R)-2,2,3-trimethyl-2-oxocyclopent-3-en-1-yl]acetate + H(+)"}
{"X":23164,"RHEA_ID":30795,"compounds":"2-oxoadipate + CoA + NAD(+) = CO2 + glutaryl-CoA + NADH"}
{"X":23165,"RHEA_ID":20242,"DIRECTION":"LR","MASTER_ID":20241,"metacyc":"NICOTINATE-N-METHYLTRANSFERASE-RXN","compounds":"nicotinate + S-adenosyl-L-methionine => N-methylnicotinate + S-adenosyl-L-homocysteine"}
{"X":23166,"RHEA_ID":20243,"compounds":"N-methylnicotinate + S-adenosyl-L-homocysteine => nicotinate + S-adenosyl-L-methionine"}
{"X":23167,"RHEA_ID":40768,"compounds":"(20S)-ginsenoside R1 + H2O => (20S)-ginsenoside Rg1 + D-xylose"}
{"X":23168,"RHEA_ID":30799,"compounds":"(3S)-hydroxybutanoyl-CoA + NAD(+) = acetoacetyl-CoA + H(+) + NADH"}
{"X":23169,"RHEA_ID":20246,"compounds":"ATP + streptomycin => 3''-adenylylstreptomycin + diphosphate"}
{"X":23170,"RHEA_ID":20247,"compounds":"3''-adenylylstreptomycin + diphosphate => ATP + streptomycin"}
{"X":23171,"RHEA_ID":40772,"compounds":"(20S)-ginsenoside Rg1 + H2O => (20S)-ginsenoside F1 + D-glucose"}
{"X":23172,"RHEA_ID":20249,"DIRECTION":"UN","MASTER_ID":20249,"ec":"5.1.1.1","compounds":"L-alanine = D-alanine"}
{"X":23173,"RHEA_ID":30804,"compounds":"4-aminobutanal + H2O + NADP(+) => 4-aminobutanoate + 2 H(+) + NADPH"}
{"X":23174,"RHEA_ID":20251,"compounds":"D-alanine => L-alanine"}
{"X":23175,"RHEA_ID":20253,"DIRECTION":"UN","MASTER_ID":20253,"ec":"4.2.1.85","compounds":"(2R,3S)-2,3-dimethylmalate = dimethylmaleate + H2O"}
{"X":23176,"RHEA_ID":30808,"compounds":"L-pipecolate + NAD(+) => Delta(1)-piperideine-2-carboxylate + H(+) + NADH"}
{"X":23177,"RHEA_ID":20255,"compounds":"dimethylmaleate + H2O => (2R,3S)-2,3-dimethylmalate"}
{"X":23178,"RHEA_ID":40780,"compounds":"2-aminopentanenitrile + H(+) + 2 H2O => L-2-aminopentanoate + NH4(+)"}
{"X":23179,"RHEA_ID":20257,"DIRECTION":"UN","MASTER_ID":20257,"ec":"1.3.1.17","metacyc":"3-METHYLENEOXINDOLE-REDUCTASE-RXN","compounds":"3-methyloxindole + NADP(+) = 3-methyleneoxindole + H(+) + NADPH"}
{"X":23180,"RHEA_ID":30816,"DIRECTION":"LR","MASTER_ID":30815,"ecocyc":"RXN-5841","metacyc":"RXN-5841","reactome":"R-HSA-8940074.3","compounds":"beta-nicotinamide D-ribonucleotide + H2O => beta-nicotinamide D-riboside + phosphate"}
{"X":23181,"RHEA_ID":20259,"compounds":"3-methyleneoxindole + H(+) + NADPH => 3-methyloxindole + NADP(+)"}
{"X":23182,"RHEA_ID":40784,"compounds":"docosanoyl-CoA + H2O => CoA + docosanoate + H(+)"}
{"X":23183,"RHEA_ID":20265,"DIRECTION":"UN","MASTER_ID":20265,"ec":"1.14.11.28","compounds":"2-oxoglutarate + L-proline + O2 = cis-3-hydroxy-L-proline + CO2 + succinate"}
{"X":23184,"RHEA_ID":30820,"compounds":"allantoin + H2O => allantoate + H(+)"}
{"X":23185,"RHEA_ID":20267,"compounds":"cis-3-hydroxy-L-proline + CO2 + succinate => 2-oxoglutarate + L-proline + O2"}
{"X":23186,"RHEA_ID":20269,"DIRECTION":"UN","MASTER_ID":20269,"ec":"4.2.2.6","compounds":"4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate = 2 5-dehydro-4-deoxy-D-glucuronate"}
{"X":23187,"RHEA_ID":30824,"DIRECTION":"LR","MASTER_ID":30823,"metacyc":"RXN-13252","compounds":"UDP-N-acetyl-alpha-D-glucosamine => H2O + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose"}
{"X":23188,"RHEA_ID":20271,"compounds":"2 5-dehydro-4-deoxy-D-glucuronate => 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate"}
{"X":23189,"RHEA_ID":40792,"compounds":"H2O + hexacosanoyl-CoA => CoA + H(+) + hexacosanoate"}
{"X":23190,"RHEA_ID":20273,"DIRECTION":"UN","MASTER_ID":20273,"ec":"1.14.16.1","compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine"}
{"X":23191,"RHEA_ID":30828,"compounds":"UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose => UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose"}
{"X":23192,"RHEA_ID":20275,"compounds":"(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2"}
{"X":23193,"RHEA_ID":30830,"compounds":"UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose <=> UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose"}
{"X":23194,"RHEA_ID":20277,"DIRECTION":"UN","MASTER_ID":20277,"ec":"2.3.1.118","compounds":"acetyl-CoA + an N-hydroxyarylamine = an N-acetoxyarylamine + CoA"}
{"X":23195,"RHEA_ID":20278,"compounds":"acetyl-CoA + an N-hydroxyarylamine => an N-acetoxyarylamine + CoA"}
{"X":23196,"RHEA_ID":20279,"compounds":"an N-acetoxyarylamine + CoA => acetyl-CoA + an N-hydroxyarylamine"}
{"X":23197,"RHEA_ID":30834,"compounds":"UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose <=> UDP-2-acetamido-2,6-dideoxy-beta-L-lyxo-hex-4-ulose"}
{"X":23198,"RHEA_ID":20281,"DIRECTION":"UN","MASTER_ID":20281,"ec":"2.8.2.24","compounds":"3'-phosphoadenylyl sulfate + desulfoglucotropeolin = adenosine 3',5'-bisphosphate + glucotropeolin + H(+)"}
{"X":23199,"RHEA_ID":30836,"compounds":"H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose => NADP(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose"}
{"X":23200,"RHEA_ID":20283,"compounds":"adenosine 3',5'-bisphosphate + glucotropeolin + H(+) => 3'-phosphoadenylyl sulfate + desulfoglucotropeolin"}
{"X":23201,"RHEA_ID":40804,"DIRECTION":"LR","MASTER_ID":40803,"metacyc":"RXN-18853","compounds":"3,6-anhydro-alpha-L-galactopyranose + H2O + NADP(+) => 3,6-anhydro-L-galactonate + 2 H(+) + NADPH"}
{"X":23202,"RHEA_ID":20285,"DIRECTION":"UN","MASTER_ID":20285,"ec":"2.4.1.211","compounds":"beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + phosphate = alpha-D-galactose 1-phosphate + N-acetyl-D-glucosamine"}
{"X":23203,"RHEA_ID":30840,"DIRECTION":"LR","MASTER_ID":30839,"metacyc":"RXN-14761","compounds":"UDP-2-acetamido-2,6-dideoxy-beta-L-talose => UDP-N-acetyl-beta-L-fucosamine"}
{"X":23204,"RHEA_ID":20287,"compounds":"alpha-D-galactose 1-phosphate + N-acetyl-D-glucosamine => beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + phosphate"}
{"X":23205,"RHEA_ID":40808,"compounds":"a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + H(+) + sn-glycerol 3-phosphocholine"}
{"X":23206,"RHEA_ID":20289,"DIRECTION":"UN","MASTER_ID":20289,"ec":"3.1.2.1","compounds":"acetyl-CoA + H2O = acetate + CoA + H(+)"}
{"X":23207,"RHEA_ID":30844,"DIRECTION":"LR","MASTER_ID":30843,"metacyc":"RXN-11318","compounds":"H2O + N-formylmaleamate => formate + H(+) + maleamate"}
{"X":23208,"RHEA_ID":20291,"compounds":"acetate + CoA + H(+) => acetyl-CoA + H2O"}
{"X":23209,"RHEA_ID":40812,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O => (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":23210,"RHEA_ID":20293,"DIRECTION":"UN","MASTER_ID":20293,"ec":"1.1.1.96","compounds":"3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD(+) = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H(+) + NADH"}
{"X":23211,"RHEA_ID":30848,"DIRECTION":"LR","MASTER_ID":30847,"reactome":"R-HSA-71046.3","compounds":"FAD + glutaryl-CoA + 2 H(+) => (2E)-butenoyl-CoA + CO2 + FADH2"}
{"X":23212,"RHEA_ID":20295,"compounds":"3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H(+) + NADH => 3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD(+)"}
{"X":23213,"RHEA_ID":40816,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O => (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)"}
{"X":23214,"RHEA_ID":20297,"DIRECTION":"UN","MASTER_ID":20297,"ec":"3.5.1.13","metacyc":"ARYL-ACYLAMIDASE-RXN","compounds":"an anilide + H2O = a carboxylate + aniline + H(+)"}
{"X":23215,"RHEA_ID":30852,"DIRECTION":"LR","MASTER_ID":30851,"metacyc":"RXN-8631","compounds":"beta-D-fructose 1-phosphate => D-glyceraldehyde + dihydroxyacetone phosphate"}
{"X":23216,"RHEA_ID":20299,"compounds":"a carboxylate + aniline + H(+) => an anilide + H2O"}
{"X":23217,"RHEA_ID":20301,"DIRECTION":"UN","MASTER_ID":20301,"ec":"6.1.1.19","compounds":"ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)"}
{"X":23218,"RHEA_ID":30856,"compounds":"dammarenediol-II => (S)-2,3-epoxysqualene + H2O"}
{"X":23219,"RHEA_ID":20303,"compounds":"AMP + diphosphate + L-arginyl-tRNA(Arg) => ATP + L-arginine + tRNA(Arg)"}
{"X":23220,"RHEA_ID":40824,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate"}
{"X":23221,"RHEA_ID":20305,"DIRECTION":"UN","MASTER_ID":20305,"ec":"1.2.1.64","compounds":"4-hydroxybenzaldehyde + H2O + NAD(+) = 4-hydroxybenzoate + 2 H(+) + NADH"}
{"X":23222,"RHEA_ID":20306,"DIRECTION":"LR","MASTER_ID":20305,"metacyc":"HYDROXYBENZALDEHYDE-OXIDATION-NAD-RXN","compounds":"4-hydroxybenzaldehyde + H2O + NAD(+) => 4-hydroxybenzoate + 2 H(+) + NADH"}
{"X":23223,"RHEA_ID":20307,"compounds":"4-hydroxybenzoate + 2 H(+) + NADH => 4-hydroxybenzaldehyde + H2O + NAD(+)"}
{"X":23224,"RHEA_ID":30862,"compounds":"dITP + H2O <=> dIDP + H(+) + phosphate"}
{"X":23225,"RHEA_ID":20309,"DIRECTION":"UN","MASTER_ID":20309,"ec":"1.11.1.6","compounds":"2 H2O2 = 2 H2O + O2"}
{"X":23226,"RHEA_ID":30864,"compounds":"4-O-phospho-L-tyrosine + H2O => L-tyrosine + phosphate"}
{"X":23227,"RHEA_ID":20310,"DIRECTION":"LR","MASTER_ID":20309,"ecocyc":"CATAL-RXN","metacyc":"CATAL-RXN","compounds":"2 H2O2 => 2 H2O + O2"}
{"X":23228,"RHEA_ID":20311,"compounds":"2 H2O + O2 => 2 H2O2"}
{"X":23229,"RHEA_ID":20313,"DIRECTION":"UN","MASTER_ID":20313,"ec":"2.7.1.158","compounds":"1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)"}
{"X":23230,"RHEA_ID":20314,"DIRECTION":"LR","MASTER_ID":20313,"metacyc":"RXN-7163","reactome":"R-HSA-1855179.2","compounds":"1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP => 1D-myo-inositol hexakisphosphate + ADP + H(+)"}
{"X":23231,"RHEA_ID":20314,"DIRECTION":"LR","MASTER_ID":20313,"metacyc":"RXN-7163","reactome":"R-HSA-1855176.2","compounds":"1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP => 1D-myo-inositol hexakisphosphate + ADP + H(+)"}
{"X":23232,"RHEA_ID":20315,"compounds":"1D-myo-inositol hexakisphosphate + ADP + H(+) => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP"}
{"X":23233,"RHEA_ID":40838,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2 H2O <=> 2 (9Z)-octadecenoate + 2 H(+) + sn-glycerol 3-phosphocholine"}
{"X":23234,"RHEA_ID":20317,"DIRECTION":"UN","MASTER_ID":20317,"ec":"1.5.1.1","compounds":"L-proline + NADP(+) = 1-pyrroline-2-carboxylate + H(+) + NADPH"}
{"X":23235,"RHEA_ID":20317,"DIRECTION":"UN","MASTER_ID":20317,"ec":"1.5.1.21","compounds":"L-proline + NADP(+) = 1-pyrroline-2-carboxylate + H(+) + NADPH"}
{"X":23236,"RHEA_ID":20317,"DIRECTION":"UN","MASTER_ID":20317,"ec":"1.5.1.49","compounds":"L-proline + NADP(+) = 1-pyrroline-2-carboxylate + H(+) + NADPH"}
{"X":23237,"RHEA_ID":30876,"compounds":"2-oxoglutarate + D-lysine => 6-amino-2-oxohexanoate + D-glutamate"}
{"X":23238,"RHEA_ID":20319,"DIRECTION":"RL","MASTER_ID":20317,"metacyc":"PYRROLINE-2-CARBOXYLATE-REDUCTASE-RXN","compounds":"1-pyrroline-2-carboxylate + H(+) + NADPH => L-proline + NADP(+)"}
{"X":23239,"RHEA_ID":30878,"compounds":"2-oxoglutarate + D-lysine <=> 6-amino-2-oxohexanoate + D-glutamate"}
{"X":23240,"RHEA_ID":20321,"DIRECTION":"UN","MASTER_ID":20321,"ec":"1.5.1.1","compounds":"L-proline + NAD(+) = 1-pyrroline-2-carboxylate + H(+) + NADH"}
{"X":23241,"RHEA_ID":30880,"compounds":"H2O + NAD(+) + prop-2-ynal => 2 H(+) + NADH + propynoate"}
{"X":23242,"RHEA_ID":20322,"compounds":"L-proline + NAD(+) => 1-pyrroline-2-carboxylate + H(+) + NADH"}
{"X":23243,"RHEA_ID":20323,"DIRECTION":"RL","MASTER_ID":20321,"metacyc":"PYRROLINE-2-CARBOXYLATE-REDUCTASE-RXN","compounds":"1-pyrroline-2-carboxylate + H(+) + NADH => L-proline + NAD(+)"}
{"X":23244,"RHEA_ID":30883,"compounds":"D-glucurono-3,6-lactone + 2 H2O + NAD(+) = D-glucarate + 3 H(+) + NADH"}
{"X":23245,"RHEA_ID":30884,"compounds":"D-glucurono-3,6-lactone + 2 H2O + NAD(+) => D-glucarate + 3 H(+) + NADH"}
{"X":23246,"RHEA_ID":20326,"compounds":"N-hydroxy-4-acetylaminobiphenyl => N-acetoxy-4-aminobiphenyl"}
{"X":23247,"RHEA_ID":20327,"compounds":"N-acetoxy-4-aminobiphenyl => N-hydroxy-4-acetylaminobiphenyl"}
{"X":23248,"RHEA_ID":30887,"compounds":"4-aminobenzoate + 6-hydroxymethyl-7,8-dihydropterin = 7,8-dihydropteroate + H2O"}
{"X":23249,"RHEA_ID":30888,"compounds":"4-aminobenzoate + 6-hydroxymethyl-7,8-dihydropterin => 7,8-dihydropteroate + H2O"}
{"X":23250,"RHEA_ID":20330,"compounds":"ATP + L-seryl-[low-density-lipoprotein receptor] => ADP + H(+) + O-phospho-L-seryl-[low-density-lipoprotein receptor]"}
{"X":23251,"RHEA_ID":20331,"compounds":"ADP + H(+) + O-phospho-L-seryl-[low-density-lipoprotein receptor] => ATP + L-seryl-[low-density-lipoprotein receptor]"}
{"X":23252,"RHEA_ID":30891,"DIRECTION":"UN","MASTER_ID":30891,"ec":"2.5.1.144","compounds":"O-acetyl-L-serine + thiosulfate = acetate + H(+) + S-sulfo-L-cysteine"}
{"X":23253,"RHEA_ID":30892,"compounds":"O-acetyl-L-serine + thiosulfate => acetate + H(+) + S-sulfo-L-cysteine"}
{"X":23254,"RHEA_ID":20334,"compounds":"[acetyl-CoA carboxylase]-L-serine + ATP => [acetyl-CoA carboxylase]-O-phospho-L-serine + ADP + H(+)"}
{"X":23255,"RHEA_ID":20335,"compounds":"[acetyl-CoA carboxylase]-O-phospho-L-serine + ADP + H(+) => [acetyl-CoA carboxylase]-L-serine + ATP"}
{"X":23256,"RHEA_ID":30895,"compounds":"H2O + O2 + propane-1,3-diamine = 3-aminopropanal + H2O2 + NH4(+)"}
{"X":23257,"RHEA_ID":20337,"DIRECTION":"UN","MASTER_ID":20337,"ec":"3.1.6.17","compounds":"(R)-2-O-sulfolactate + H2O = (R)-lactate + H(+) + sulfate"}
{"X":23258,"RHEA_ID":20338,"DIRECTION":"LR","MASTER_ID":20337,"metacyc":"D-LACTATE-2-SULFATASE-RXN","compounds":"(R)-2-O-sulfolactate + H2O => (R)-lactate + H(+) + sulfate"}
{"X":23259,"RHEA_ID":20339,"compounds":"(R)-lactate + H(+) + sulfate => (R)-2-O-sulfolactate + H2O"}
{"X":23260,"RHEA_ID":30900,"DIRECTION":"LR","MASTER_ID":30899,"metacyc":"RXN-8474","compounds":"bis(beta-D-glucosyl) crocetin + UDP-alpha-D-glucose => beta-D-gentiobiosyl beta-D-glucosyl crocetin + H(+) + UDP"}
{"X":23261,"RHEA_ID":20342,"compounds":"sn-glycerol 3-phosphate + UDP-alpha-D-galactose => 1-O-alpha-D-galactosyl-sn-glycerol 3-phosphate + H(+) + UDP"}
{"X":23262,"RHEA_ID":20343,"compounds":"1-O-alpha-D-galactosyl-sn-glycerol 3-phosphate + H(+) + UDP => sn-glycerol 3-phosphate + UDP-alpha-D-galactose"}
{"X":23263,"RHEA_ID":30903,"DIRECTION":"UN","MASTER_ID":30903,"ec":"2.1.1.210","compounds":"demethylspheroidene + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + spheroidene"}
{"X":23264,"RHEA_ID":30904,"DIRECTION":"LR","MASTER_ID":30903,"metacyc":"RXN-10669","compounds":"demethylspheroidene + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + spheroidene"}
{"X":23265,"RHEA_ID":20346,"compounds":"[thioredoxin]-dithiol + NADP(+) => [thioredoxin]-disulfide + H(+) + NADPH"}
{"X":23266,"RHEA_ID":20347,"DIRECTION":"RL","MASTER_ID":20345,"ecocyc":"THIOREDOXIN-REDUCT-NADPH-RXN","compounds":"[thioredoxin]-disulfide + H(+) + NADPH => [thioredoxin]-dithiol + NADP(+)"}
{"X":23267,"RHEA_ID":30908,"compounds":"(S)-3-methyl-2-oxopentanoate + CoA + NAD(+) => 2-methylbutanoyl-CoA + CO2 + NADH"}
{"X":23268,"RHEA_ID":20350,"DIRECTION":"LR","MASTER_ID":20349,"metacyc":"TOLUENE-2-MONOOXYGENASE-RXN","compounds":"H(+) + NADH + O2 + toluene => 2-hydroxytoluene + H2O + NAD(+)"}
{"X":23269,"RHEA_ID":20351,"compounds":"2-hydroxytoluene + H2O + NAD(+) => H(+) + NADH + O2 + toluene"}
{"X":23270,"RHEA_ID":20352,"compounds":"H(+) + NADH + O2 + toluene <=> 2-hydroxytoluene + H2O + NAD(+)"}
{"X":23271,"RHEA_ID":30912,"DIRECTION":"LR","MASTER_ID":30911,"metacyc":"RXN-12339","compounds":"H2O + sphingomyelin => a carboxylate + sphing-4-enine-phosphocholine"}
{"X":23272,"RHEA_ID":20354,"compounds":"A + chloride + H(+) + trichloroethene => AH2 + tetrachloroethene"}
{"X":23273,"RHEA_ID":20355,"DIRECTION":"RL","MASTER_ID":20353,"metacyc":"1.97.1.8-RXN","compounds":"AH2 + tetrachloroethene => A + chloride + H(+) + trichloroethene"}
{"X":23274,"RHEA_ID":30915,"DIRECTION":"UN","MASTER_ID":30915,"ec":"3.5.1.109","compounds":"a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = a fatty acid + beta-D-glucosyl-(1<->1)-sphing-4-enine"}
{"X":23275,"RHEA_ID":30916,"DIRECTION":"LR","MASTER_ID":30915,"metacyc":"RXN-12340","compounds":"a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O => a fatty acid + beta-D-glucosyl-(1<->1)-sphing-4-enine"}
{"X":23276,"RHEA_ID":20358,"DIRECTION":"LR","MASTER_ID":20357,"ecocyc":"HCAMULTI-RXN","metacyc":"HCAMULTI-RXN","compounds":"3-phenylpropanoate + H(+) + NADH + O2 => 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+)"}
{"X":23277,"RHEA_ID":20359,"compounds":"3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+) => 3-phenylpropanoate + H(+) + NADH + O2"}
{"X":23278,"RHEA_ID":30919,"DIRECTION":"UN","MASTER_ID":30919,"ec":"1.3.99.27","compounds":"A + rhodopin = (3E)-3,4-didehydrorhodopin + AH2"}
{"X":23279,"RHEA_ID":30920,"DIRECTION":"LR","MASTER_ID":30919,"metacyc":"RXN-11647","compounds":"A + rhodopin => (3E)-3,4-didehydrorhodopin + AH2"}
{"X":23280,"RHEA_ID":20362,"DIRECTION":"LR","MASTER_ID":20361,"metacyc":"RXN3O-58","compounds":"4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":23281,"RHEA_ID":20363,"compounds":"3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":23282,"RHEA_ID":20364,"compounds":"4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":23283,"RHEA_ID":30924,"DIRECTION":"LR","MASTER_ID":30923,"metacyc":"RXN-12028","compounds":"(R)-glycerate + ADP-alpha-D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + ADP + H(+)"}
{"X":23284,"RHEA_ID":20366,"DIRECTION":"LR","MASTER_ID":20365,"metacyc":"2.1.1.103-RXN","compounds":"phosphoethanolamine + S-adenosyl-L-methionine => H(+) + N-methylethanolamine phosphate + S-adenosyl-L-homocysteine"}
{"X":23285,"RHEA_ID":20367,"compounds":"H(+) + N-methylethanolamine phosphate + S-adenosyl-L-homocysteine => phosphoethanolamine + S-adenosyl-L-methionine"}
{"X":23286,"RHEA_ID":30927,"DIRECTION":"UN","MASTER_ID":30927,"ec":"3.2.1.172","compounds":"2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnopyranose + H2O = 5-dehydro-4-deoxy-D-glucuronate + L-rhamnopyranose"}
{"X":23287,"RHEA_ID":30928,"compounds":"2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnopyranose + H2O => 5-dehydro-4-deoxy-D-glucuronate + L-rhamnopyranose"}
{"X":23288,"RHEA_ID":20370,"compounds":"betaine aldehyde + H2O + O2 => betaine + H(+) + H2O2"}
{"X":23289,"RHEA_ID":20371,"compounds":"betaine + H(+) + H2O2 => betaine aldehyde + H2O + O2"}
{"X":23290,"RHEA_ID":30931,"compounds":"L-cysteine + O-acetyl-L-homoserine = acetate + H(+) + L,L-cystathionine"}
{"X":23291,"RHEA_ID":30932,"compounds":"L-cysteine + O-acetyl-L-homoserine => acetate + H(+) + L,L-cystathionine"}
{"X":23292,"RHEA_ID":20374,"DIRECTION":"LR","MASTER_ID":20373,"ecocyc":"PROPIONATE--COA-LIGASE-RXN","compounds":"ATP + CoA + propanoate => AMP + diphosphate + propanoyl-CoA"}
{"X":23293,"RHEA_ID":20375,"compounds":"AMP + diphosphate + propanoyl-CoA => ATP + CoA + propanoate"}
{"X":23294,"RHEA_ID":30935,"compounds":"H2O + nicotinate beta-D-ribonucleotide = beta-D-ribosylnicotinate + phosphate"}
{"X":23295,"RHEA_ID":30936,"compounds":"H2O + nicotinate beta-D-ribonucleotide => beta-D-ribosylnicotinate + phosphate"}
{"X":23296,"RHEA_ID":20378,"DIRECTION":"LR","MASTER_ID":20377,"metacyc":"1.1.1.209-RXN","compounds":"3alpha-hydroxy-5alpha-androstan-17-one + NADP(+) => 5alpha-androstan-3,17-dione + H(+) + NADPH"}
{"X":23297,"RHEA_ID":20379,"compounds":"5alpha-androstan-3,17-dione + H(+) + NADPH => 3alpha-hydroxy-5alpha-androstan-17-one + NADP(+)"}
{"X":23298,"RHEA_ID":30939,"DIRECTION":"UN","MASTER_ID":30939,"ec":"2.7.4.6","compounds":"ATP + dIDP = ADP + dITP"}
{"X":23299,"RHEA_ID":30940,"compounds":"ATP + dIDP => ADP + dITP"}
{"X":23300,"RHEA_ID":20382,"DIRECTION":"LR","MASTER_ID":20381,"metacyc":"1.1.1.209-RXN","compounds":"3alpha-hydroxy-5alpha-androstan-17-one + NAD(+) => 5alpha-androstan-3,17-dione + H(+) + NADH"}
{"X":23301,"RHEA_ID":20383,"compounds":"5alpha-androstan-3,17-dione + H(+) + NADH => 3alpha-hydroxy-5alpha-androstan-17-one + NAD(+)"}
{"X":23302,"RHEA_ID":30943,"compounds":"FAD + H(+) + octanoyl-CoA = (2E)-octenoyl-CoA + FADH2"}
{"X":23303,"RHEA_ID":30944,"DIRECTION":"LR","MASTER_ID":30943,"reactome":"R-HSA-77338.2","compounds":"FAD + H(+) + octanoyl-CoA => (2E)-octenoyl-CoA + FADH2"}
{"X":23304,"RHEA_ID":20386,"DIRECTION":"LR","MASTER_ID":20385,"metacyc":"TAXIFOLIN-8-MONOOXYGENASE-RXN","compounds":"(2R,3R)-dihydroquercetin + H(+) + NADH + O2 => (2R,3R)-2,3-dihydrogossypetin + H2O + NAD(+)"}
{"X":23305,"RHEA_ID":20387,"compounds":"(2R,3R)-2,3-dihydrogossypetin + H2O + NAD(+) => (2R,3R)-dihydroquercetin + H(+) + NADH + O2"}
{"X":23306,"RHEA_ID":30947,"DIRECTION":"UN","MASTER_ID":30947,"ec":"4.2.3.84","compounds":"(2E,6E)-farnesyl diphosphate + H2O = 10-epi-gamma-eudesmol + diphosphate"}
{"X":23307,"RHEA_ID":30948,"DIRECTION":"LR","MASTER_ID":30947,"metacyc":"RXN-10637","compounds":"(2E,6E)-farnesyl diphosphate + H2O => 10-epi-gamma-eudesmol + diphosphate"}
{"X":23308,"RHEA_ID":20390,"DIRECTION":"LR","MASTER_ID":20389,"metacyc":"TAXIFOLIN-8-MONOOXYGENASE-RXN","compounds":"(2R,3R)-dihydroquercetin + H(+) + NADPH + O2 => (2R,3R)-2,3-dihydrogossypetin + H2O + NADP(+)"}
{"X":23309,"RHEA_ID":20391,"compounds":"(2R,3R)-2,3-dihydrogossypetin + H2O + NADP(+) => (2R,3R)-dihydroquercetin + H(+) + NADPH + O2"}
{"X":23310,"RHEA_ID":30951,"DIRECTION":"UN","MASTER_ID":30951,"ec":"4.2.3.85","compounds":"(2E,6E)-farnesyl diphosphate + H2O = alpha-eudesmol + diphosphate"}
{"X":23311,"RHEA_ID":30952,"DIRECTION":"LR","MASTER_ID":30951,"metacyc":"RXN-10635","compounds":"(2E,6E)-farnesyl diphosphate + H2O => alpha-eudesmol + diphosphate"}
{"X":23312,"RHEA_ID":20394,"DIRECTION":"LR","MASTER_ID":20393,"ecocyc":"2.3.1.49-RXN","metacyc":"2.3.1.49-RXN","compounds":"holo-[citrate lyase ACP] + S-acetylphosphopantotheine => acetyl-[citrate lyase ACP] + D-pantetheine 4'-phosphate"}
{"X":23313,"RHEA_ID":20395,"compounds":"acetyl-[citrate lyase ACP] + D-pantetheine 4'-phosphate => holo-[citrate lyase ACP] + S-acetylphosphopantotheine"}
{"X":23314,"RHEA_ID":30955,"DIRECTION":"UN","MASTER_ID":30955,"ec":"1.3.5.6","compounds":"9,9'-di-cis-zeta-carotene + 2 a quinone = 7,7',9,9'-tetra-cis-lycopene + 2 a quinol"}
{"X":23315,"RHEA_ID":30956,"compounds":"9,9'-di-cis-zeta-carotene + 2 a quinone => 7,7',9,9'-tetra-cis-lycopene + 2 a quinol"}
{"X":23316,"RHEA_ID":20398,"DIRECTION":"LR","MASTER_ID":20397,"ecocyc":"O-SUCCHOMOSERLYASE-RXN","metacyc":"O-SUCCHOMOSERLYASE-RXN","compounds":"L-cysteine + O-succinyl-L-homoserine => H(+) + L,L-cystathionine + succinate"}
{"X":23317,"RHEA_ID":20399,"compounds":"H(+) + L,L-cystathionine + succinate => L-cysteine + O-succinyl-L-homoserine"}
{"X":23318,"RHEA_ID":30959,"compounds":"9,9'-di-cis-zeta-carotene + a quinone = 7,9,9'-tri-cis-neurosporene + a quinol"}
{"X":23319,"RHEA_ID":30960,"DIRECTION":"LR","MASTER_ID":30959,"metacyc":"RXN-11356","compounds":"9,9'-di-cis-zeta-carotene + a quinone => 7,9,9'-tri-cis-neurosporene + a quinol"}
{"X":23320,"RHEA_ID":20402,"DIRECTION":"LR","MASTER_ID":20401,"ecocyc":"BETA-LACTAMASE-RXN","metacyc":"BETA-LACTAMASE-RXN","compounds":"a beta-lactam + H2O => a substituted beta-amino acid"}
{"X":23321,"RHEA_ID":20403,"compounds":"a substituted beta-amino acid => a beta-lactam + H2O"}
{"X":23322,"RHEA_ID":30964,"DIRECTION":"LR","MASTER_ID":30963,"metacyc":"RXN-11357","compounds":"7,9,9'-tri-cis-neurosporene + a quinone => 7,7',9,9'-tetra-cis-lycopene + a quinol"}
{"X":23323,"RHEA_ID":20406,"DIRECTION":"LR","MASTER_ID":20405,"metacyc":"N-ACETYLDIAMINOPIMELATE-DEACETYLASE-RXN","compounds":"H2O + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate => (2S,6S)-2,6-diaminoheptanedioate + acetate"}
{"X":23324,"RHEA_ID":20407,"compounds":"(2S,6S)-2,6-diaminoheptanedioate + acetate => H2O + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate"}
{"X":23325,"RHEA_ID":30967,"DIRECTION":"UN","MASTER_ID":30967,"ec":"5.2.1.12","compounds":"9,9',15-tri-cis-zeta-carotene = 9,9'-di-cis-zeta-carotene"}
{"X":23326,"RHEA_ID":30968,"DIRECTION":"LR","MASTER_ID":30967,"metacyc":"RXN-11354","compounds":"9,9',15-tri-cis-zeta-carotene => 9,9'-di-cis-zeta-carotene"}
{"X":23327,"RHEA_ID":20410,"compounds":"alpha-D-glucose 1-phosphate + riboflavin => D-glucose + FMN"}
{"X":23328,"RHEA_ID":20411,"compounds":"D-glucose + FMN => alpha-D-glucose 1-phosphate + riboflavin"}
{"X":23329,"RHEA_ID":30971,"DIRECTION":"UN","MASTER_ID":30971,"ec":"5.2.1.13","compounds":"7,7',9,9'-tetra-cis-lycopene = all-trans-lycopene"}
{"X":23330,"RHEA_ID":20413,"DIRECTION":"UN","MASTER_ID":20413,"ec":"2.1.1.112","compounds":"glucuronoxylan D-glucuronate + n S-adenosyl-L-methionine = glucuronoxylan 4-O-methyl-D-glucuronate + n H(+) + n S-adenosyl-L-homocysteine"}
{"X":23331,"RHEA_ID":20414,"DIRECTION":"LR","MASTER_ID":20413,"metacyc":"GLUCURONOXYLAN-4-O-METHYLTRANSFERASE-RXN","compounds":"glucuronoxylan D-glucuronate + n S-adenosyl-L-methionine => glucuronoxylan 4-O-methyl-D-glucuronate + n H(+) + n S-adenosyl-L-homocysteine"}
{"X":23332,"RHEA_ID":20415,"compounds":"glucuronoxylan 4-O-methyl-D-glucuronate + n H(+) + n S-adenosyl-L-homocysteine => glucuronoxylan D-glucuronate + n S-adenosyl-L-methionine"}
{"X":23333,"RHEA_ID":30975,"DIRECTION":"UN","MASTER_ID":30975,"ec":"1.3.99.30","compounds":"15-cis-phytoene + 5 A = 5 AH2 + all-trans-3,4-didehydrolycopene"}
{"X":23334,"RHEA_ID":30976,"compounds":"15-cis-phytoene + 5 A => 5 AH2 + all-trans-3,4-didehydrolycopene"}
{"X":23335,"RHEA_ID":20418,"DIRECTION":"LR","MASTER_ID":20417,"metacyc":"RXN-3361","compounds":"coelenterazine + O2 => CO2 + coelenteramide + hnu"}
{"X":23336,"RHEA_ID":20419,"compounds":"CO2 + coelenteramide + hnu => coelenterazine + O2"}
{"X":23337,"RHEA_ID":30979,"compounds":"A + all-trans-lycopene = AH2 + all-trans-3,4-didehydrolycopene"}
{"X":23338,"RHEA_ID":20421,"DIRECTION":"UN","MASTER_ID":20421,"ec":"3.2.1.122","compounds":"alpha-maltose 6'-phosphate + H2O = D-glucose + D-glucose 6-phosphate"}
{"X":23339,"RHEA_ID":20422,"DIRECTION":"LR","MASTER_ID":20421,"metacyc":"MALTOSE-6-PHOSPHATE-GLUCOSIDASE-RXN","compounds":"alpha-maltose 6'-phosphate + H2O => D-glucose + D-glucose 6-phosphate"}
{"X":23340,"RHEA_ID":20423,"compounds":"D-glucose + D-glucose 6-phosphate => alpha-maltose 6'-phosphate + H2O"}
{"X":23341,"RHEA_ID":40953,"compounds":"acetate + L-2,4-diaminobutanoate => (2S)-2-acetamido-4-aminobutanoate + H2O"}
{"X":23342,"RHEA_ID":20425,"DIRECTION":"UN","MASTER_ID":20425,"ec":"6.4.1.7","compounds":"2-oxoglutarate + ATP + hydrogencarbonate = ADP + H(+) + oxalosuccinate + phosphate"}
{"X":23343,"RHEA_ID":20426,"DIRECTION":"LR","MASTER_ID":20425,"metacyc":"RXN-8457","compounds":"2-oxoglutarate + ATP + hydrogencarbonate => ADP + H(+) + oxalosuccinate + phosphate"}
{"X":23344,"RHEA_ID":20427,"compounds":"ADP + H(+) + oxalosuccinate + phosphate => 2-oxoglutarate + ATP + hydrogencarbonate"}
{"X":23345,"RHEA_ID":30987,"DIRECTION":"UN","MASTER_ID":30987,"ec":"5.4.99.32","compounds":"(S)-2,3-epoxysqualene = (17Z)-protosta-17(20),24-dien-3beta-ol"}
{"X":23346,"RHEA_ID":30988,"compounds":"(S)-2,3-epoxysqualene => (17Z)-protosta-17(20),24-dien-3beta-ol"}
{"X":23347,"RHEA_ID":20430,"DIRECTION":"LR","MASTER_ID":20429,"metacyc":"APIGENIN-4-O-METHYLTRANSFERASE-RXN","compounds":"apigenin + S-adenosyl-L-methionine => acacetin + H(+) + S-adenosyl-L-homocysteine"}
{"X":23348,"RHEA_ID":20431,"compounds":"acacetin + H(+) + S-adenosyl-L-homocysteine => apigenin + S-adenosyl-L-methionine"}
{"X":23349,"RHEA_ID":30991,"DIRECTION":"UN","MASTER_ID":30991,"ec":"1.14.14.134","compounds":"beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = 24-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":23350,"RHEA_ID":20433,"DIRECTION":"UN","MASTER_ID":20433,"ec":"1.1.1.9","compounds":"NAD(+) + xylitol = D-xylulose + H(+) + NADH"}
{"X":23351,"RHEA_ID":20434,"DIRECTION":"LR","MASTER_ID":20433,"reactome":"R-HSA-5662471.2","compounds":"NAD(+) + xylitol => D-xylulose + H(+) + NADH"}
{"X":23352,"RHEA_ID":20435,"compounds":"D-xylulose + H(+) + NADH => NAD(+) + xylitol"}
{"X":23353,"RHEA_ID":30995,"DIRECTION":"UN","MASTER_ID":30995,"ec":"1.14.14.134","compounds":"O2 + reduced [NADPH--hemoprotein reductase] + sophoradiol = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + soyasapogenol B"}
{"X":23354,"RHEA_ID":30996,"DIRECTION":"LR","MASTER_ID":30995,"metacyc":"RXN-8084","compounds":"O2 + reduced [NADPH--hemoprotein reductase] + sophoradiol => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + soyasapogenol B"}
{"X":23355,"RHEA_ID":20438,"compounds":"5D-5-O-methyl-chiro-inositol + NADP(+) => 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADPH"}
{"X":23356,"RHEA_ID":20439,"compounds":"2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADPH => 5D-5-O-methyl-chiro-inositol + NADP(+)"}
{"X":23357,"RHEA_ID":30999,"DIRECTION":"UN","MASTER_ID":30999,"ec":"5.4.99.33","compounds":"(S)-2,3-epoxysqualene = cucurbitadienol"}
{"X":23358,"RHEA_ID":20441,"DIRECTION":"UN","MASTER_ID":20441,"ec":"1.13.11.20","compounds":"L-cysteine + O2 = 3-sulfino-L-alanine + H(+)"}
{"X":23359,"RHEA_ID":20442,"DIRECTION":"LR","MASTER_ID":20441,"metacyc":"CYSTEINE-DIOXYGENASE-RXN","reactome":"R-HSA-1614645.3","compounds":"L-cysteine + O2 => 3-sulfino-L-alanine + H(+)"}
{"X":23360,"RHEA_ID":20443,"compounds":"3-sulfino-L-alanine + H(+) => L-cysteine + O2"}
{"X":23361,"RHEA_ID":31003,"DIRECTION":"UN","MASTER_ID":31003,"ec":"5.4.99.34","compounds":"(S)-2,3-epoxysqualene = germanicol"}
{"X":23362,"RHEA_ID":31004,"compounds":"(S)-2,3-epoxysqualene => germanicol"}
{"X":23363,"RHEA_ID":20446,"compounds":"L-arogenate + oxaloacetate => L-aspartate + prephenate"}
{"X":23364,"RHEA_ID":20447,"compounds":"L-aspartate + prephenate => L-arogenate + oxaloacetate"}
{"X":23365,"RHEA_ID":31007,"DIRECTION":"UN","MASTER_ID":31007,"ec":"5.4.99.39","compounds":"(S)-2,3-epoxysqualene = beta-amyrin"}
{"X":23366,"RHEA_ID":31008,"compounds":"(S)-2,3-epoxysqualene => beta-amyrin"}
{"X":23367,"RHEA_ID":20450,"DIRECTION":"LR","MASTER_ID":20449,"metacyc":"CHLORIDAZON-CATECHOL-DIOXYGENASE-RXN","compounds":"5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one + O2 => 5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one + 2 H(+)"}
{"X":23368,"RHEA_ID":20451,"compounds":"5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one + 2 H(+) => 5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one + O2"}
{"X":23369,"RHEA_ID":31011,"DIRECTION":"UN","MASTER_ID":31011,"ec":"5.4.99.38","compounds":"(S)-2,3-epoxysqualene = camelliol C"}
{"X":23370,"RHEA_ID":31012,"compounds":"(S)-2,3-epoxysqualene => camelliol C"}
{"X":23371,"RHEA_ID":20454,"DIRECTION":"LR","MASTER_ID":20453,"metacyc":"SCOPOLETIN-GLUCOSYLTRANSFERASE-RXN","compounds":"scopoletin + UDP-alpha-D-glucose => H(+) + scopolin + UDP"}
{"X":23372,"RHEA_ID":20455,"compounds":"H(+) + scopolin + UDP => scopoletin + UDP-alpha-D-glucose"}
{"X":23373,"RHEA_ID":31015,"DIRECTION":"UN","MASTER_ID":31015,"ec":"4.1.1.92","compounds":"H(+) + indole-3-carboxylate = CO2 + indole"}
{"X":23374,"RHEA_ID":20457,"DIRECTION":"UN","MASTER_ID":20457,"ec":"1.1.1.116","compounds":"D-arabinose + NAD(+) = D-arabinono-1,4-lactone + H(+) + NADH"}
{"X":23375,"RHEA_ID":20457,"DIRECTION":"UN","MASTER_ID":20457,"ec":"1.1.1.117","compounds":"D-arabinose + NAD(+) = D-arabinono-1,4-lactone + H(+) + NADH"}
{"X":23376,"RHEA_ID":20458,"DIRECTION":"LR","MASTER_ID":20457,"metacyc":"D-ARABINOSE-1-DEHYDROGENASE-RXN","compounds":"D-arabinose + NAD(+) => D-arabinono-1,4-lactone + H(+) + NADH"}
{"X":23377,"RHEA_ID":20458,"DIRECTION":"LR","MASTER_ID":20457,"metacyc":"1.1.1.117-RXN","compounds":"D-arabinose + NAD(+) => D-arabinono-1,4-lactone + H(+) + NADH"}
{"X":23378,"RHEA_ID":31020,"DIRECTION":"LR","MASTER_ID":31019,"metacyc":"RXN-12223","compounds":"4 AH2 + all-trans-4,4'-diapolycopene + 4 O2 => 4 A + all-trans-4,4'-diapolycopene-4,4'-dial + 6 H2O"}
{"X":23379,"RHEA_ID":31021,"compounds":"4 A + all-trans-4,4'-diapolycopene-4,4'-dial + 6 H2O => 4 AH2 + all-trans-4,4'-diapolycopene + 4 O2"}
{"X":23380,"RHEA_ID":20461,"DIRECTION":"UN","MASTER_ID":20461,"ec":"2.1.1.344","compounds":"an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + 3 S-adenosyl-L-methionine = an N,N,N-trimethylornithine lipid + 3 H(+) + 3 S-adenosyl-L-homocysteine"}
{"X":23381,"RHEA_ID":20462,"DIRECTION":"LR","MASTER_ID":20461,"metacyc":"RXN-18679","compounds":"an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + 3 S-adenosyl-L-methionine => an N,N,N-trimethylornithine lipid + 3 H(+) + 3 S-adenosyl-L-homocysteine"}
{"X":23382,"RHEA_ID":31024,"DIRECTION":"LR","MASTER_ID":31023,"metacyc":"RXN-9895","compounds":"squalene => dammara-20,24-diene"}
{"X":23383,"RHEA_ID":31025,"compounds":"dammara-20,24-diene => squalene"}
{"X":23384,"RHEA_ID":20465,"DIRECTION":"UN","MASTER_ID":20465,"ec":"2.4.1.212","compounds":"[hyaluronan](n) + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP"}
{"X":23385,"RHEA_ID":20466,"compounds":"[hyaluronan](n) + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP"}
{"X":23386,"RHEA_ID":31028,"compounds":"2-trans-(+)-abscisate + UDP-alpha-D-glucose => beta-D-glucopyranosyl trans-(+)-abscisate + UDP"}
{"X":23387,"RHEA_ID":20468,"DIRECTION":"BI","MASTER_ID":20465,"metacyc":"RXN-11627","compounds":"[hyaluronan](n) + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP"}
{"X":23388,"RHEA_ID":20469,"DIRECTION":"UN","MASTER_ID":20469,"ec":"3.2.2.12","compounds":"H2O + IMP = D-ribose 5-phosphate + hypoxanthine"}
{"X":23389,"RHEA_ID":20470,"DIRECTION":"LR","MASTER_ID":20469,"metacyc":"INOSINATE-NUCLEOSIDASE-RXN","compounds":"H2O + IMP => D-ribose 5-phosphate + hypoxanthine"}
{"X":23390,"RHEA_ID":31032,"DIRECTION":"LR","MASTER_ID":31031,"metacyc":"RXN-8155","compounds":"2-cis-(+)-abscisate + UDP-alpha-D-glucose => beta-D-glucopyranosyl cis-(+)-abscisate + UDP"}
{"X":23391,"RHEA_ID":31033,"compounds":"beta-D-glucopyranosyl cis-(+)-abscisate + UDP => 2-cis-(+)-abscisate + UDP-alpha-D-glucose"}
{"X":23392,"RHEA_ID":20473,"compounds":"(R)-lipoyl-5'-AMP + [lipoyl-carrier protein]-L-lysine = [lipoyl-carrier protein]-(R)-N(6)-lipoyl-L-lysine + AMP + 2 H(+)"}
{"X":23393,"RHEA_ID":20474,"DIRECTION":"LR","MASTER_ID":20473,"ecocyc":"RXN-8655","metacyc":"RXN-8655","compounds":"(R)-lipoyl-5'-AMP + [lipoyl-carrier protein]-L-lysine => [lipoyl-carrier protein]-(R)-N(6)-lipoyl-L-lysine + AMP + 2 H(+)"}
{"X":23394,"RHEA_ID":31036,"compounds":"arabidiol => (S)-2,3-epoxysqualene + H2O"}
{"X":23395,"RHEA_ID":31037,"compounds":"(S)-2,3-epoxysqualene + H2O => arabidiol"}
{"X":23396,"RHEA_ID":20481,"DIRECTION":"UN","MASTER_ID":20481,"ec":"2.8.2.10","compounds":"3'-phosphoadenylyl sulfate + coelenterazine h = adenosine 3',5'-bisphosphate + H(+) + luciferyl sulfate"}
{"X":23397,"RHEA_ID":20482,"compounds":"3'-phosphoadenylyl sulfate + coelenterazine h => adenosine 3',5'-bisphosphate + H(+) + luciferyl sulfate"}
{"X":23398,"RHEA_ID":20483,"DIRECTION":"RL","MASTER_ID":20481,"metacyc":"RENILLA-LUCIFERIN-SULFOTRANSFERASE-RXN","compounds":"adenosine 3',5'-bisphosphate + H(+) + luciferyl sulfate => 3'-phosphoadenylyl sulfate + coelenterazine h"}
{"X":23399,"RHEA_ID":31041,"compounds":"(2E)-dodecenoyl-CoA + FADH2 => dodecanoyl-CoA + FAD + H(+)"}
{"X":23400,"RHEA_ID":20485,"DIRECTION":"UN","MASTER_ID":20485,"ec":"1.14.19.65","compounds":"(S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase] = (S)-cheilanthifoline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":23401,"RHEA_ID":20486,"DIRECTION":"LR","MASTER_ID":20485,"metacyc":"1.14.21.2-RXN","compounds":"(S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase] => (S)-cheilanthifoline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":23402,"RHEA_ID":31044,"compounds":"(S)-methylmalonate semialdehyde + H2O + NAD(+) => 2 H(+) + methylmalonate + NADH"}
{"X":23403,"RHEA_ID":31045,"compounds":"2 H(+) + methylmalonate + NADH => (S)-methylmalonate semialdehyde + H2O + NAD(+)"}
{"X":23404,"RHEA_ID":20489,"DIRECTION":"UN","MASTER_ID":20489,"ec":"2.3.2.11","metacyc":"ALANYLPHOSPHATIDYLGLYCEROL-SYNTHASE-RXN","compounds":"1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-alanyl-tRNA(Ala) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-alanyl)-sn-glycerol + tRNA(Ala)"}
{"X":23405,"RHEA_ID":20490,"compounds":"1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-alanyl-tRNA(Ala) => 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-alanyl)-sn-glycerol + tRNA(Ala)"}
{"X":23406,"RHEA_ID":20491,"compounds":"1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-alanyl)-sn-glycerol + tRNA(Ala) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-alanyl-tRNA(Ala)"}
{"X":23407,"RHEA_ID":20493,"DIRECTION":"UN","MASTER_ID":20493,"ec":"2.4.1.244","compounds":"an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-galactosamine = an N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP"}
{"X":23408,"RHEA_ID":20494,"compounds":"an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-galactosamine => an N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP"}
{"X":23409,"RHEA_ID":31052,"compounds":"(3R)-beta-leucine + H2O + NAD(+) => 3-oxo-4-methylpentanoate + H(+) + NADH + NH4(+)"}
{"X":23410,"RHEA_ID":20496,"DIRECTION":"BI","MASTER_ID":20493,"metacyc":"2.4.1.244-RXN","compounds":"an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-galactosamine <=> an N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP"}
{"X":23411,"RHEA_ID":20497,"DIRECTION":"UN","MASTER_ID":20497,"ec":"2.3.1.87","compounds":"2-arylethylamine + acetyl-CoA = CoA + H(+) + N-acetyl-2-arylethylamine"}
{"X":23412,"RHEA_ID":20498,"compounds":"2-arylethylamine + acetyl-CoA => CoA + H(+) + N-acetyl-2-arylethylamine"}
{"X":23413,"RHEA_ID":20499,"compounds":"CoA + H(+) + N-acetyl-2-arylethylamine => 2-arylethylamine + acetyl-CoA"}
{"X":23414,"RHEA_ID":31057,"compounds":"estrone + H(+) + sulfate => estrone 3-sulfate + H2O"}
{"X":23415,"RHEA_ID":20505,"DIRECTION":"UN","MASTER_ID":20505,"ec":"4.3.2.9","compounds":"an alpha-(gamma-L-glutamyl)-L-amino acid = 5-oxo-L-proline + an L-alpha-amino acid"}
{"X":23416,"RHEA_ID":20506,"DIRECTION":"LR","MASTER_ID":20505,"metacyc":"GAMMA-GLUTAMYLCYCLOTRANSFERASE-RXN","compounds":"an alpha-(gamma-L-glutamyl)-L-amino acid => 5-oxo-L-proline + an L-alpha-amino acid"}
{"X":23417,"RHEA_ID":20507,"compounds":"5-oxo-L-proline + an L-alpha-amino acid => an alpha-(gamma-L-glutamyl)-L-amino acid"}
{"X":23418,"RHEA_ID":20509,"DIRECTION":"UN","MASTER_ID":20509,"ec":"2.7.1.103","compounds":"ATP + viomycin = ADP + H(+) + O-phosphoviomycin"}
{"X":23419,"RHEA_ID":20510,"compounds":"ATP + viomycin => ADP + H(+) + O-phosphoviomycin"}
{"X":23420,"RHEA_ID":31064,"DIRECTION":"LR","MASTER_ID":31063,"reactome":"R-HSA-70745.3","compounds":"3-methylbutanoyl-CoA + FAD + H(+) => 3-methylbut-2-enoyl-CoA + FADH2"}
{"X":23421,"RHEA_ID":31065,"compounds":"3-methylbut-2-enoyl-CoA + FADH2 => 3-methylbutanoyl-CoA + FAD + H(+)"}
{"X":23422,"RHEA_ID":20513,"DIRECTION":"UN","MASTER_ID":20513,"ec":"4.1.1.76","compounds":"2-aryl-2-methylmalonate + H(+) = 2-arylpropionate + CO2"}
{"X":23423,"RHEA_ID":20514,"compounds":"2-aryl-2-methylmalonate + H(+) => 2-arylpropionate + CO2"}
{"X":23424,"RHEA_ID":31068,"compounds":"6-amino-2-oxohexanoate => Delta(1)-piperideine-2-carboxylate + H2O"}
{"X":23425,"RHEA_ID":20517,"DIRECTION":"UN","MASTER_ID":20517,"ec":"5.1.3.7","compounds":"UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-galactosamine"}
{"X":23426,"RHEA_ID":20518,"compounds":"UDP-N-acetyl-alpha-D-glucosamine => UDP-N-acetyl-alpha-D-galactosamine"}
{"X":23427,"RHEA_ID":20519,"compounds":"UDP-N-acetyl-alpha-D-galactosamine => UDP-N-acetyl-alpha-D-glucosamine"}
{"X":23428,"RHEA_ID":31073,"compounds":"(S)-3-amino-2-methylpropanoate + pyruvate => (S)-methylmalonate semialdehyde + L-alanine"}
{"X":23429,"RHEA_ID":20521,"DIRECTION":"UN","MASTER_ID":20521,"ec":"1.1.1.30","compounds":"(R)-3-hydroxybutanoate + NAD(+) = acetoacetate + H(+) + NADH"}
{"X":23430,"RHEA_ID":20522,"DIRECTION":"LR","MASTER_ID":20521,"reactome":"R-HSA-5696457.1","compounds":"(R)-3-hydroxybutanoate + NAD(+) => acetoacetate + H(+) + NADH"}
{"X":23431,"RHEA_ID":31076,"compounds":"(3S)-hydroxydodecanoyl-CoA => (2E)-dodecenoyl-CoA + H2O"}
{"X":23432,"RHEA_ID":20523,"DIRECTION":"RL","MASTER_ID":20521,"reactome":"R-HSA-73912.2","compounds":"acetoacetate + H(+) + NADH => (R)-3-hydroxybutanoate + NAD(+)"}
{"X":23433,"RHEA_ID":41048,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol => 1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA"}
{"X":23434,"RHEA_ID":20525,"DIRECTION":"UN","MASTER_ID":20525,"ec":"6.3.1.6","compounds":"ATP + ethylamine + L-glutamate = ADP + H(+) + N(5)-ethyl-L-glutamine + phosphate"}
{"X":23435,"RHEA_ID":31080,"compounds":"3-hydroxyisovaleryl-CoA => 3-methylbut-2-enoyl-CoA + H2O"}
{"X":23436,"RHEA_ID":20527,"compounds":"ADP + H(+) + N(5)-ethyl-L-glutamine + phosphate => ATP + ethylamine + L-glutamate"}
{"X":23437,"RHEA_ID":41052,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + tetradecanoyl-CoA => 1,2-di-(9Z)-octadecenoyl-3-tetradecanoyl-sn-glycerol + CoA"}
{"X":23438,"RHEA_ID":20529,"DIRECTION":"UN","MASTER_ID":20529,"ec":"1.2.3.14","compounds":"2-cis-(+)-abscisic aldehyde + H2O + O2 = 2-cis-(+)-abscisate + H(+) + H2O2"}
{"X":23439,"RHEA_ID":20530,"DIRECTION":"LR","MASTER_ID":20529,"metacyc":"1.2.3.14-RXN","compounds":"2-cis-(+)-abscisic aldehyde + H2O + O2 => 2-cis-(+)-abscisate + H(+) + H2O2"}
{"X":23440,"RHEA_ID":20531,"compounds":"2-cis-(+)-abscisate + H(+) + H2O2 => 2-cis-(+)-abscisic aldehyde + H2O + O2"}
{"X":23441,"RHEA_ID":41056,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + dodecanoyl-CoA => 1,2-di-(9Z)-octadecenoyl-3-dodecanoyl-sn-glycerol + CoA"}
{"X":23442,"RHEA_ID":20533,"DIRECTION":"UN","MASTER_ID":20533,"ec":"3.1.3.74","compounds":"H2O + pyridoxal 5'-phosphate = phosphate + pyridoxal"}
{"X":23443,"RHEA_ID":31088,"compounds":"acetyl-CoA + octanoyl-CoA => 3-oxodecanoyl-CoA + CoA"}
{"X":23444,"RHEA_ID":20535,"compounds":"phosphate + pyridoxal => H2O + pyridoxal 5'-phosphate"}
{"X":23445,"RHEA_ID":41060,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + octadecanoyl-CoA => 1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + CoA"}
{"X":23446,"RHEA_ID":20537,"DIRECTION":"UN","MASTER_ID":20537,"ec":"3.1.4.14","compounds":"H2O + holo-[ACP] = apo-[ACP] + D-pantetheine 4'-phosphate + H(+)"}
{"X":23447,"RHEA_ID":31092,"compounds":"acetyl-CoA + dodecanoyl-CoA => 3-oxotetradecanoyl-CoA + CoA"}
{"X":23448,"RHEA_ID":20539,"compounds":"apo-[ACP] + D-pantetheine 4'-phosphate + H(+) => H2O + holo-[ACP]"}
{"X":23449,"RHEA_ID":20541,"compounds":"H(+) + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADPH + O2 = 2 H2O + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADP(+)"}
{"X":23450,"RHEA_ID":31096,"compounds":"2-methylpropanoyl-CoA + A => (2E)-2-methylpropenoyl-CoA + AH2"}
{"X":23451,"RHEA_ID":20543,"compounds":"2 H2O + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADP(+) => H(+) + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADPH + O2"}
{"X":23452,"RHEA_ID":41068,"compounds":"1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":23453,"RHEA_ID":20545,"DIRECTION":"UN","MASTER_ID":20545,"ec":"1.14.13.9","compounds":"H(+) + L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + H2O + NADP(+)"}
{"X":23454,"RHEA_ID":31100,"DIRECTION":"LR","MASTER_ID":31099,"metacyc":"MEPROPCOA-FAD-RXN","reactome":"R-HSA-70859.3","compounds":"2-methylpropanoyl-CoA + FAD + H(+) => (2E)-2-methylpropenoyl-CoA + FADH2"}
{"X":23455,"RHEA_ID":20547,"compounds":"3-hydroxy-L-kynurenine + H2O + NADP(+) => H(+) + L-kynurenine + NADPH + O2"}
{"X":23456,"RHEA_ID":31102,"compounds":"2-methylpropanoyl-CoA + FAD + H(+) <=> (2E)-2-methylpropenoyl-CoA + FADH2"}
{"X":23457,"RHEA_ID":20549,"DIRECTION":"UN","MASTER_ID":20549,"ec":"1.8.2.2","compounds":"2 [Fe(III)cytochrome c] + 2 thiosulfate = 2 [Fe(II)cytochrome c] + 2 H(+) + tetrathionate"}
{"X":23458,"RHEA_ID":31104,"compounds":"7,8-dihydrofolate + NADP(+) => folate + H(+) + NADPH"}
{"X":23459,"RHEA_ID":20551,"compounds":"2 [Fe(II)cytochrome c] + 2 H(+) + tetrathionate => 2 [Fe(III)cytochrome c] + 2 thiosulfate"}
{"X":23460,"RHEA_ID":20553,"DIRECTION":"UN","MASTER_ID":20553,"ec":"5.1.99.1","compounds":"(R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA"}
{"X":23461,"RHEA_ID":31108,"DIRECTION":"LR","MASTER_ID":31107,"metacyc":"RXN-10815","compounds":"3-phenylpyruvate + O2 => (2-hydroxyphenyl)acetate + CO2"}
{"X":23462,"RHEA_ID":20555,"DIRECTION":"RL","MASTER_ID":20553,"reactome":"R-HSA-71020.2","compounds":"(S)-methylmalonyl-CoA => (R)-methylmalonyl-CoA"}
{"X":23463,"RHEA_ID":41080,"compounds":"1-(9Z-octadecenoyl)-sn-glycerol + ATP => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":23464,"RHEA_ID":20557,"DIRECTION":"UN","MASTER_ID":20557,"ec":"3.5.1.5","compounds":"2 H(+) + H2O + urea = CO2 + 2 NH4(+)"}
{"X":23465,"RHEA_ID":20558,"DIRECTION":"LR","MASTER_ID":20557,"macie":"M0087","compounds":"2 H(+) + H2O + urea => CO2 + 2 NH4(+)"}
{"X":23466,"RHEA_ID":31113,"DIRECTION":"RL","MASTER_ID":31111,"reactome":"R-HSA-77321.2","compounds":"3-oxohexanoyl-CoA + CoA => acetyl-CoA + butanoyl-CoA"}
{"X":23467,"RHEA_ID":20561,"DIRECTION":"UN","MASTER_ID":20561,"ec":"4.1.1.40","compounds":"3-hydroxypyruvate + H(+) = CO2 + glycolaldehyde"}
{"X":23468,"RHEA_ID":20562,"compounds":"3-hydroxypyruvate + H(+) => CO2 + glycolaldehyde"}
{"X":23469,"RHEA_ID":20563,"compounds":"CO2 + glycolaldehyde => 3-hydroxypyruvate + H(+)"}
{"X":23470,"RHEA_ID":41088,"compounds":"1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol => 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine"}
{"X":23471,"RHEA_ID":20565,"DIRECTION":"UN","MASTER_ID":20565,"ec":"4.2.3.10","compounds":"(2E)-geranyl diphosphate + H2O = (1S,2S,4R)-endo-fenchol + diphosphate"}
{"X":23472,"RHEA_ID":20566,"DIRECTION":"LR","MASTER_ID":20565,"metacyc":"4.2.3.10-RXN","compounds":"(2E)-geranyl diphosphate + H2O => (1S,2S,4R)-endo-fenchol + diphosphate"}
{"X":23473,"RHEA_ID":20567,"compounds":"(1S,2S,4R)-endo-fenchol + diphosphate => (2E)-geranyl diphosphate + H2O"}
{"X":23474,"RHEA_ID":51062,"compounds":"AH2 + androsta-1,4-diene-3,17-dione => 5alpha-androst-1-ene-3,17-dione + A"}
{"X":23475,"RHEA_ID":20569,"DIRECTION":"UN","MASTER_ID":20569,"ec":"3.5.3.1","compounds":"H2O + L-arginine = L-ornithine + urea"}
{"X":23476,"RHEA_ID":20570,"DIRECTION":"LR","MASTER_ID":20569,"reactome":"R-HSA-452036.3","compounds":"H2O + L-arginine => L-ornithine + urea"}
{"X":23477,"RHEA_ID":20570,"DIRECTION":"LR","MASTER_ID":20569,"reactome":"R-HSA-70569.3","compounds":"H2O + L-arginine => L-ornithine + urea"}
{"X":23478,"RHEA_ID":20571,"compounds":"L-ornithine + urea => H2O + L-arginine"}
{"X":23479,"RHEA_ID":31127,"compounds":"3-O-methylgallate + O2 = 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + methanol"}
{"X":23480,"RHEA_ID":20573,"DIRECTION":"UN","MASTER_ID":20573,"ec":"1.14.15.18","compounds":"calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = calcitriol + H2O + 2 oxidized [adrenodoxin]"}
{"X":23481,"RHEA_ID":20574,"DIRECTION":"LR","MASTER_ID":20573,"metacyc":"CALCIDIOL-1-MONOOXYGENASE-RXN","compounds":"calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => calcitriol + H2O + 2 oxidized [adrenodoxin]"}
{"X":23482,"RHEA_ID":20575,"compounds":"calcitriol + H2O + 2 oxidized [adrenodoxin] => calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}
{"X":23483,"RHEA_ID":31131,"compounds":"5,10-methenyltetrahydrofolate + H2O + N(1)-(5-phospho-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + 2 H(+) + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide"}
{"X":23484,"RHEA_ID":20577,"DIRECTION":"UN","MASTER_ID":20577,"ec":"5.4.4.3","compounds":"3-hydroxyaminophenol = aminohydroquinone"}
{"X":23485,"RHEA_ID":20578,"compounds":"3-hydroxyaminophenol => aminohydroquinone"}
{"X":23486,"RHEA_ID":20579,"compounds":"aminohydroquinone => 3-hydroxyaminophenol"}
{"X":23487,"RHEA_ID":41105,"compounds":"(9Z)-octadecenoate + 1-hexadecanoyl-3-octadecanoyl-sn-glycerol + H(+) => 1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O"}
{"X":23488,"RHEA_ID":20581,"DIRECTION":"UN","MASTER_ID":20581,"ec":"1.7.1.10","compounds":"H2O + NAD(+) + NH4(+) = 2 H(+) + hydroxylamine + NADH"}
{"X":23489,"RHEA_ID":20582,"compounds":"H2O + NAD(+) + NH4(+) => 2 H(+) + hydroxylamine + NADH"}
{"X":23490,"RHEA_ID":20583,"DIRECTION":"RL","MASTER_ID":20581,"metacyc":"HYDROXYLAMINE-REDUCTASE-NADH-RXN","compounds":"2 H(+) + hydroxylamine + NADH => H2O + NAD(+) + NH4(+)"}
{"X":23491,"RHEA_ID":20585,"DIRECTION":"UN","MASTER_ID":20585,"ec":"1.14.19.62","compounds":"loganin + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + secologanin"}
{"X":23492,"RHEA_ID":20586,"DIRECTION":"LR","MASTER_ID":20585,"metacyc":"1.3.3.9-RXN","compounds":"loganin + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + secologanin"}
{"X":23493,"RHEA_ID":20587,"compounds":"H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + secologanin => loganin + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":23494,"RHEA_ID":31143,"compounds":"(3S)-hydroxyhexanoyl-CoA + NAD(+) = 3-oxohexanoyl-CoA + H(+) + NADH"}
{"X":23495,"RHEA_ID":20589,"compounds":"glutaryl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-glutaconyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":23496,"RHEA_ID":20590,"compounds":"glutaryl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-glutaconyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":23497,"RHEA_ID":20591,"compounds":"(2E)-glutaconyl-CoA + reduced [electron-transfer flavoprotein] => glutaryl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":23498,"RHEA_ID":31147,"compounds":"3,4-dihydroxyphenylethyleneglycol + NAD(+) = 3,4-dihydroxymandelaldehyde + H(+) + NADH"}
{"X":23499,"RHEA_ID":20593,"DIRECTION":"UN","MASTER_ID":20593,"ec":"3.5.1.33","compounds":"H2O + N-acetyl-D-glucosamine = acetate + D-glucosamine"}
{"X":23500,"RHEA_ID":20594,"compounds":"H2O + N-acetyl-D-glucosamine => acetate + D-glucosamine"}
{"X":23501,"RHEA_ID":20595,"compounds":"acetate + D-glucosamine => H2O + N-acetyl-D-glucosamine"}
{"X":23502,"RHEA_ID":31151,"compounds":"H2O + L-selenocystathionine = 2-oxobutanoate + L-selenocysteine + NH4(+)"}
{"X":23503,"RHEA_ID":20597,"DIRECTION":"UN","MASTER_ID":20597,"ec":"1.8.1.6","compounds":"2 L-cysteine + NAD(+) = H(+) + L-cystine + NADH"}
{"X":23504,"RHEA_ID":20598,"compounds":"2 L-cysteine + NAD(+) => H(+) + L-cystine + NADH"}
{"X":23505,"RHEA_ID":41124,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+)"}
{"X":23506,"RHEA_ID":31155,"compounds":"(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NAD(+) = erythro-4-hydroxy-L-glutamate + H(+) + NADH"}
{"X":23507,"RHEA_ID":20601,"compounds":"formaldehyde + mycothiol + NAD(+) = H(+) + NADH + S-formylmycothiol"}
{"X":23508,"RHEA_ID":20602,"compounds":"formaldehyde + mycothiol + NAD(+) => H(+) + NADH + S-formylmycothiol"}
{"X":23509,"RHEA_ID":41128,"compounds":"1-dodecanoyl-sn-glycero-3-phosphocholine + H2O => 1-dodecanoyl-sn-glycerol + H(+) + phosphocholine"}
{"X":23510,"RHEA_ID":31159,"compounds":"(3S)-hydroxyhexadecanoyl-CoA + NAD(+) = 3-oxohexadecanoyl-CoA + H(+) + NADH"}
{"X":23511,"RHEA_ID":20605,"DIRECTION":"UN","MASTER_ID":20605,"ec":"3.5.4.1","compounds":"cytosine + H(+) + H2O = NH4(+) + uracil"}
{"X":23512,"RHEA_ID":20606,"DIRECTION":"LR","MASTER_ID":20605,"ecocyc":"CYTDEAM-RXN","metacyc":"CYTDEAM-RXN","compounds":"cytosine + H(+) + H2O => NH4(+) + uracil"}
{"X":23513,"RHEA_ID":31163,"compounds":"(3S)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2O"}
{"X":23514,"RHEA_ID":20609,"DIRECTION":"UN","MASTER_ID":20609,"ec":"4.1.2.28","compounds":"2-dehydro-3-deoxy-D-arabinonate = glycolaldehyde + pyruvate"}
{"X":23515,"RHEA_ID":20610,"compounds":"2-dehydro-3-deoxy-D-arabinonate => glycolaldehyde + pyruvate"}
{"X":23516,"RHEA_ID":20613,"DIRECTION":"UN","MASTER_ID":20613,"ec":"2.8.2.11","compounds":"3'-phosphoadenylyl sulfate + a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine = adenosine 3',5'-bisphosphate + H(+) + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine"}
{"X":23517,"RHEA_ID":20614,"compounds":"3'-phosphoadenylyl sulfate + a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine => adenosine 3',5'-bisphosphate + H(+) + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine"}
{"X":23518,"RHEA_ID":41140,"compounds":"1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+)"}
{"X":23519,"RHEA_ID":31171,"compounds":"(3S)-hydroxytetradecanoyl-CoA = (2E)-tetradecenoyl-CoA + H2O"}
{"X":23520,"RHEA_ID":20617,"DIRECTION":"UN","MASTER_ID":20617,"ec":"1.3.3.12","compounds":"L-galactono-1,4-lactone + O2 = H(+) + H2O2 + L-ascorbate"}
{"X":23521,"RHEA_ID":20618,"DIRECTION":"LR","MASTER_ID":20617,"metacyc":"1.3.3.12-RXN","compounds":"L-galactono-1,4-lactone + O2 => H(+) + H2O2 + L-ascorbate"}
{"X":23522,"RHEA_ID":41144,"compounds":"1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)"}
{"X":23523,"RHEA_ID":31175,"compounds":"(2E)-2-methylpropenoyl-CoA + H2O = (S)-3-hydroxyisobutanoyl-CoA"}
{"X":23524,"RHEA_ID":20621,"DIRECTION":"UN","MASTER_ID":20621,"ec":"7.2.2.12","compounds":"ATP + H2O + Zn(2+)(in) = ADP + H(+) + phosphate + Zn(2+)(out)"}
{"X":23525,"RHEA_ID":20622,"DIRECTION":"LR","MASTER_ID":20621,"ecocyc":"RXN0-5205","metacyc":"RXN0-5205","compounds":"ATP + H2O + Zn(2+)(in) => ADP + H(+) + phosphate + Zn(2+)(out)"}
{"X":23526,"RHEA_ID":20623,"compounds":"ADP + H(+) + phosphate + Zn(2+)(out) => ATP + H2O + Zn(2+)(in)"}
{"X":23527,"RHEA_ID":41149,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O"}
{"X":23528,"RHEA_ID":20625,"DIRECTION":"UN","MASTER_ID":20625,"ec":"1.12.2.1","compounds":"2 [Fe(III)-cytochrome c3] + H2 = 2 [Fe(II)-cytochrome c3] + 2 H(+)"}
{"X":23529,"RHEA_ID":20626,"compounds":"2 [Fe(III)-cytochrome c3] + H2 => 2 [Fe(II)-cytochrome c3] + 2 H(+)"}
{"X":23530,"RHEA_ID":20627,"compounds":"2 [Fe(II)-cytochrome c3] + 2 H(+) => 2 [Fe(III)-cytochrome c3] + H2"}
{"X":23531,"RHEA_ID":20629,"DIRECTION":"UN","MASTER_ID":20629,"ec":"3.1.3.16","compounds":"H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate"}
{"X":23532,"RHEA_ID":31185,"DIRECTION":"RL","MASTER_ID":31183,"reactome":"R-HSA-77309.2","compounds":"3-oxododecanoyl-CoA + CoA => acetyl-CoA + decanoyl-CoA"}
{"X":23533,"RHEA_ID":20631,"compounds":"L-seryl-[protein] + phosphate => H2O + O-phospho-L-seryl-[protein]"}
{"X":23534,"RHEA_ID":20633,"DIRECTION":"UN","MASTER_ID":20633,"ec":"2.3.2.30","compounds":"a (3R)-hydroxyacyl-[ACP] + L-ornithine = a lyso-ornithine lipid + H(+) + holo-[ACP]"}
{"X":23535,"RHEA_ID":31189,"compounds":"3-oxodecanoyl-CoA + H(+) + NADH => (3S)-hydroxydecanoyl-CoA + NAD(+)"}
{"X":23536,"RHEA_ID":20635,"compounds":"a lyso-ornithine lipid + H(+) + holo-[ACP] => a (3R)-hydroxyacyl-[ACP] + L-ornithine"}
{"X":23537,"RHEA_ID":20637,"DIRECTION":"UN","MASTER_ID":20637,"ec":"1.1.99.28","compounds":"D-fructose + D-glucose = D-glucono-1,5-lactone + D-sorbitol"}
{"X":23538,"RHEA_ID":31193,"DIRECTION":"RL","MASTER_ID":31191,"reactome":"R-HSA-77344.2","compounds":"(2E)-decenoyl-CoA + H2O => (3S)-hydroxydecanoyl-CoA"}
{"X":23539,"RHEA_ID":20639,"compounds":"D-glucono-1,5-lactone + D-sorbitol => D-fructose + D-glucose"}
{"X":23540,"RHEA_ID":31195,"compounds":"(3S)-hydroxyoctanoyl-CoA + NAD(+) = 3-oxooctanoyl-CoA + H(+) + NADH"}
{"X":23541,"RHEA_ID":20641,"DIRECTION":"UN","MASTER_ID":20641,"ec":"1.1.1.23","compounds":"H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH"}
{"X":23542,"RHEA_ID":31197,"compounds":"3-oxooctanoyl-CoA + H(+) + NADH => (3S)-hydroxyoctanoyl-CoA + NAD(+)"}
{"X":23543,"RHEA_ID":20643,"compounds":"3 H(+) + L-histidine + 2 NADH => H2O + L-histidinol + 2 NAD(+)"}
{"X":23544,"RHEA_ID":31199,"compounds":"(3S)-hydroxyoctanoyl-CoA = (2E)-octenoyl-CoA + H2O"}
{"X":23545,"RHEA_ID":20649,"DIRECTION":"UN","MASTER_ID":20649,"ec":"1.3.1.5","metacyc":"CUCURBITACIN-DELTA-23-REDUCTASE-RXN","compounds":"23,24-dihydrocucurbitacin B + NADP(+) = cucurbitacin B + H(+) + NADPH"}
{"X":23546,"RHEA_ID":31201,"DIRECTION":"RL","MASTER_ID":31199,"reactome":"R-HSA-77333.2","compounds":"(2E)-octenoyl-CoA + H2O => (3S)-hydroxyoctanoyl-CoA"}
{"X":23547,"RHEA_ID":20651,"compounds":"cucurbitacin B + H(+) + NADPH => 23,24-dihydrocucurbitacin B + NADP(+)"}
{"X":23548,"RHEA_ID":31203,"compounds":"acetyl-CoA + hexanoyl-CoA = 3-oxooctanoyl-CoA + CoA"}
{"X":23549,"RHEA_ID":20653,"DIRECTION":"UN","MASTER_ID":20653,"ec":"1.3.1.5","metacyc":"CUCURBITACIN-DELTA-23-REDUCTASE-RXN","compounds":"23,24-dihydrocucurbitacin B + NAD(+) = cucurbitacin B + H(+) + NADH"}
{"X":23550,"RHEA_ID":31205,"DIRECTION":"RL","MASTER_ID":31203,"reactome":"R-HSA-77329.2","compounds":"3-oxooctanoyl-CoA + CoA => acetyl-CoA + hexanoyl-CoA"}
{"X":23551,"RHEA_ID":20655,"compounds":"cucurbitacin B + H(+) + NADH => 23,24-dihydrocucurbitacin B + NAD(+)"}
{"X":23552,"RHEA_ID":31207,"compounds":"FAD + H(+) + hexanoyl-CoA = (2E)-hexenoyl-CoA + FADH2"}
{"X":23553,"RHEA_ID":20657,"DIRECTION":"UN","MASTER_ID":20657,"ec":"3.5.5.5","compounds":"4-chlorophenylacetonitrile + 2 H2O = 4-chlorophenylacetate + NH4(+)"}
{"X":23554,"RHEA_ID":31209,"compounds":"(2E)-hexenoyl-CoA + FADH2 => FAD + H(+) + hexanoyl-CoA"}
{"X":23555,"RHEA_ID":20659,"compounds":"4-chlorophenylacetate + NH4(+) => 4-chlorophenylacetonitrile + 2 H2O"}
{"X":23556,"RHEA_ID":31211,"compounds":"ATP + H2O + L-selenomethionine = diphosphate + L-adenosylselenomethionine + phosphate"}
{"X":23557,"RHEA_ID":20661,"DIRECTION":"UN","MASTER_ID":20661,"ec":"3.4.13.22","compounds":"D-alanyl-D-alanine + H2O = 2 D-alanine"}
{"X":23558,"RHEA_ID":31213,"compounds":"diphosphate + L-adenosylselenomethionine + phosphate => ATP + H2O + L-selenomethionine"}
{"X":23559,"RHEA_ID":20663,"compounds":"2 D-alanine => D-alanyl-D-alanine + H2O"}
{"X":23560,"RHEA_ID":20665,"DIRECTION":"UN","MASTER_ID":20665,"ec":"1.1.1.263","compounds":"1,5-anhydro-D-glucitol + NADP(+) = 1,5-anhydro-D-fructose + H(+) + NADPH"}
{"X":23561,"RHEA_ID":31217,"compounds":"(5-hydroxyindol-3-yl)acetate + 2 H(+) + NADH => (5-hydroxyindol-3-yl)acetaldehyde + H2O + NAD(+)"}
{"X":23562,"RHEA_ID":20667,"DIRECTION":"RL","MASTER_ID":20665,"metacyc":"1.1.1.263-RXN","compounds":"1,5-anhydro-D-fructose + H(+) + NADPH => 1,5-anhydro-D-glucitol + NADP(+)"}
{"X":23563,"RHEA_ID":31219,"compounds":"5-hydroxykynurenamine + CO2 = 5-hydroxy-L-kynurenine + H(+)"}
{"X":23564,"RHEA_ID":20669,"compounds":"3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate + NAD(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADH"}
{"X":23565,"RHEA_ID":31221,"compounds":"5-hydroxy-L-kynurenine + H(+) => 5-hydroxykynurenamine + CO2"}
{"X":23566,"RHEA_ID":20671,"compounds":"4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADH => 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate + NAD(+)"}
{"X":23567,"RHEA_ID":31223,"compounds":"cis-beta-D-glucosyl-2-hydroxycinnamate + H2O = beta-D-glucose + cis-2-coumarate"}
{"X":23568,"RHEA_ID":20673,"compounds":"3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADPH"}
{"X":23569,"RHEA_ID":31225,"compounds":"beta-D-glucose + cis-2-coumarate => cis-beta-D-glucosyl-2-hydroxycinnamate + H2O"}
{"X":23570,"RHEA_ID":20675,"compounds":"4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADPH => 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate + NADP(+)"}
{"X":23571,"RHEA_ID":31227,"compounds":"N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine-diphosphoundecaprenol + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine + UDP"}
{"X":23572,"RHEA_ID":20677,"DIRECTION":"UN","MASTER_ID":20677,"ec":"2.4.1.103","compounds":"alizarin + UDP-alpha-D-glucose = 1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone + H(+) + UDP"}
{"X":23573,"RHEA_ID":20678,"DIRECTION":"LR","MASTER_ID":20677,"metacyc":"ALIZARIN-2-BETA-GLUCOSYLTRANSFERASE-RXN","compounds":"alizarin + UDP-alpha-D-glucose => 1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone + H(+) + UDP"}
{"X":23574,"RHEA_ID":41200,"compounds":"1-hexadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate"}
{"X":23575,"RHEA_ID":31231,"compounds":"4-acetamidobutanal + H2O + NAD(+) = 4-acetamidobutanoate + 2 H(+) + NADH"}
{"X":23576,"RHEA_ID":20681,"DIRECTION":"UN","MASTER_ID":20681,"ec":"2.4.1.215","compounds":"cis-zeatin + UDP-alpha-D-glucose = H(+) + O-beta-D-glucosyl-cis-zeatin + UDP"}
{"X":23577,"RHEA_ID":20682,"DIRECTION":"LR","MASTER_ID":20681,"metacyc":"RXN-4735","compounds":"cis-zeatin + UDP-alpha-D-glucose => H(+) + O-beta-D-glucosyl-cis-zeatin + UDP"}
{"X":23578,"RHEA_ID":41204,"compounds":"1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)"}
{"X":23579,"RHEA_ID":31235,"compounds":"2-oxoglutarate + erythro-4-hydroxy-L-glutamate = (4R)-4-hydroxy-2-oxoglutarate + L-glutamate"}
{"X":23580,"RHEA_ID":20685,"DIRECTION":"UN","MASTER_ID":20685,"ec":"1.1.1.16","compounds":"galactitol + NAD(+) = H(+) + keto-D-tagatose + NADH"}
{"X":23581,"RHEA_ID":20686,"DIRECTION":"LR","MASTER_ID":20685,"metacyc":"GALACTITOL-2-DEHYDROGENASE-RXN","compounds":"galactitol + NAD(+) => H(+) + keto-D-tagatose + NADH"}
{"X":23582,"RHEA_ID":20687,"compounds":"H(+) + keto-D-tagatose + NADH => galactitol + NAD(+)"}
{"X":23583,"RHEA_ID":31239,"compounds":"4 H(+) + uroporphyrinogen I = 4 CO2 + coproporphyrinogen I"}
{"X":23584,"RHEA_ID":20689,"DIRECTION":"UN","MASTER_ID":20689,"ec":"3.1.1.42","compounds":"chlorogenate + H2O = (E)-caffeate + H(+) + L-quinate"}
{"X":23585,"RHEA_ID":20690,"DIRECTION":"LR","MASTER_ID":20689,"metacyc":"CHLOROGENATE-HYDROLASE-RXN","compounds":"chlorogenate + H2O => (E)-caffeate + H(+) + L-quinate"}
{"X":23586,"RHEA_ID":41212,"DIRECTION":"LR","MASTER_ID":41211,"metacyc":"RXN-14711","compounds":"(indol-3-yl)acetate + H(+) + NADH + O2 => 2-hydroxy-(1H-indol-3-yl)acetate + H2O + NAD(+)"}
{"X":23587,"RHEA_ID":31243,"compounds":"H2O + L-4-hydroxyglutamate semialdehyde + NAD(+) = erythro-4-hydroxy-L-glutamate + 2 H(+) + NADH"}
{"X":23588,"RHEA_ID":20696,"DIRECTION":"UN","MASTER_ID":20696,"ec":"1.15.1.1","compounds":"2 H(+) + 2 superoxide = H2O2 + O2"}
{"X":23589,"RHEA_ID":20697,"DIRECTION":"LR","MASTER_ID":20696,"ecocyc":"SUPEROX-DISMUT-RXN","macie":"M0138","metacyc":"SUPEROX-DISMUT-RXN","reactome":"R-HSA-1222462.1","compounds":"2 H(+) + 2 superoxide => H2O2 + O2"}
{"X":23590,"RHEA_ID":41216,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+)"}
{"X":23591,"RHEA_ID":20697,"DIRECTION":"LR","MASTER_ID":20696,"ecocyc":"SUPEROX-DISMUT-RXN","macie":"M0138","metacyc":"SUPEROX-DISMUT-RXN","reactome":"R-HSA-3299691.1","compounds":"2 H(+) + 2 superoxide => H2O2 + O2"}
{"X":23592,"RHEA_ID":20697,"DIRECTION":"LR","MASTER_ID":20696,"ecocyc":"SUPEROX-DISMUT-RXN","macie":"M0138","metacyc":"SUPEROX-DISMUT-RXN","reactome":"R-HSA-3299682.1","compounds":"2 H(+) + 2 superoxide => H2O2 + O2"}
{"X":23593,"RHEA_ID":20697,"DIRECTION":"LR","MASTER_ID":20696,"ecocyc":"SUPEROX-DISMUT-RXN","macie":"M0138","metacyc":"SUPEROX-DISMUT-RXN","reactome":"R-HSA-3777112.2","compounds":"2 H(+) + 2 superoxide => H2O2 + O2"}
{"X":23594,"RHEA_ID":20698,"compounds":"H2O2 + O2 => 2 H(+) + 2 superoxide"}
{"X":23595,"RHEA_ID":20700,"DIRECTION":"UN","MASTER_ID":20700,"ec":"2.7.1.130","compounds":"ATP + lipid A disaccharide (E. coli) = ADP + H(+) + lipid IVA (E. coli)"}
{"X":23596,"RHEA_ID":20701,"DIRECTION":"LR","MASTER_ID":20700,"ecocyc":"TETRAACYLDISACC4KIN-RXN","metacyc":"TETRAACYLDISACC4KIN-RXN","compounds":"ATP + lipid A disaccharide (E. coli) => ADP + H(+) + lipid IVA (E. coli)"}
{"X":23597,"RHEA_ID":20702,"compounds":"ADP + H(+) + lipid IVA (E. coli) => ATP + lipid A disaccharide (E. coli)"}
{"X":23598,"RHEA_ID":31256,"compounds":"(2S)-2-acetolactate => 3-hydroxy-3-methyl-2-oxobutanoate"}
{"X":23599,"RHEA_ID":20704,"DIRECTION":"UN","MASTER_ID":20704,"ec":"2.3.1.36","compounds":"a D-alpha-amino acid + acetyl-CoA = an N-acetyl-D-amino acid + CoA + H(+)"}
{"X":23600,"RHEA_ID":41228,"compounds":"(S)-4-hydroxymandelate + O2 => 4-hydroxyphenylglyoxylate + H2O2"}
{"X":23601,"RHEA_ID":20706,"compounds":"an N-acetyl-D-amino acid + CoA + H(+) => a D-alpha-amino acid + acetyl-CoA"}
{"X":23602,"RHEA_ID":31260,"compounds":"but-3-ynal + H2O + NAD(+) => 3-butynoate + 2 H(+) + NADH"}
{"X":23603,"RHEA_ID":20708,"DIRECTION":"UN","MASTER_ID":20708,"ec":"2.7.1.27","metacyc":"ERYTHRITOL-KINASE-RXN","compounds":"ATP + erythritol = ADP + D-erythritol 4-phosphate + H(+)"}
{"X":23604,"RHEA_ID":20710,"compounds":"ADP + D-erythritol 4-phosphate + H(+) => ATP + erythritol"}
{"X":23605,"RHEA_ID":31264,"compounds":"but-3-ynal + H(+) + pyrroloquinoline quinol => but-3-yn-1-ol + pyrroloquinoline quinone"}
{"X":23606,"RHEA_ID":20712,"compounds":"6-carboxyhexanoyl-CoA + H(+) + L-alanine = 8-amino-7-oxononanoate + CO2 + CoA"}
{"X":23607,"RHEA_ID":41240,"compounds":"N-acyl (9Z,12Z)-octadecadienoate octadecasphin-4E-enine + O2 => N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine"}
{"X":23608,"RHEA_ID":20714,"compounds":"8-amino-7-oxononanoate + CO2 + CoA => 6-carboxyhexanoyl-CoA + H(+) + L-alanine"}
{"X":23609,"RHEA_ID":31268,"compounds":"6-hydroxyhexanoate + NADP(+) => 6-oxohexanoate + H(+) + NADPH"}
{"X":23610,"RHEA_ID":20716,"DIRECTION":"UN","MASTER_ID":20716,"ec":"3.5.4.28","compounds":"H(+) + H2O + S-adenosyl-L-homocysteine = NH4(+) + S-inosyl-L-homocysteine"}
{"X":23611,"RHEA_ID":41244,"compounds":"N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine => N-acyl-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecenoate (4E)-octadecasphin-4-enine"}
{"X":23612,"RHEA_ID":20718,"compounds":"NH4(+) + S-inosyl-L-homocysteine => H(+) + H2O + S-adenosyl-L-homocysteine"}
{"X":23613,"RHEA_ID":31272,"DIRECTION":"LR","MASTER_ID":31271,"metacyc":"RXN-12763","compounds":"1-hydroxy-2-naphthoate + 2 H(+) + NADH + O2 => CO2 + H2O + NAD(+) + naphthalene-1,2-diol"}
{"X":23614,"RHEA_ID":20720,"DIRECTION":"UN","MASTER_ID":20720,"ec":"2.3.1.164","compounds":"H2O + isopenicillin N + phenylacetyl-CoA = CoA + H(+) + L-2-aminoadipate + penicillin G"}
{"X":23615,"RHEA_ID":20721,"compounds":"H2O + isopenicillin N + phenylacetyl-CoA => CoA + H(+) + L-2-aminoadipate + penicillin G"}
{"X":23616,"RHEA_ID":20722,"compounds":"CoA + H(+) + L-2-aminoadipate + penicillin G => H2O + isopenicillin N + phenylacetyl-CoA"}
{"X":23617,"RHEA_ID":31276,"DIRECTION":"LR","MASTER_ID":31275,"metacyc":"3-HYDROXYISOBUTYRATE-DEHYDROGENASE-RXN","compounds":"(S)-3-hydroxy-2-methylpropanoate + NAD(+) => (S)-methylmalonate semialdehyde + H(+) + NADH"}
{"X":23618,"RHEA_ID":20724,"DIRECTION":"UN","MASTER_ID":20724,"ec":"4.2.1.17","compounds":"a 4-saturated-(3S)-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O"}
{"X":23619,"RHEA_ID":20725,"compounds":"a 4-saturated-(3S)-hydroxyacyl-CoA => a (3E)-enoyl-CoA + H2O"}
{"X":23620,"RHEA_ID":20726,"compounds":"a (3E)-enoyl-CoA + H2O => a 4-saturated-(3S)-hydroxyacyl-CoA"}
{"X":23621,"RHEA_ID":20728,"DIRECTION":"UN","MASTER_ID":20728,"ec":"1.4.3.11","compounds":"H2O + L-glutamate + O2 = 2-oxoglutarate + H2O2 + NH4(+)"}
{"X":23622,"RHEA_ID":20729,"DIRECTION":"LR","MASTER_ID":20728,"metacyc":"L-GLUTAMATE-OXIDASE-RXN","compounds":"H2O + L-glutamate + O2 => 2-oxoglutarate + H2O2 + NH4(+)"}
{"X":23623,"RHEA_ID":20730,"compounds":"2-oxoglutarate + H2O2 + NH4(+) => H2O + L-glutamate + O2"}
{"X":23624,"RHEA_ID":31284,"DIRECTION":"LR","MASTER_ID":31283,"reactome":"R-HSA-188467.2","compounds":"FAD + H(+) + sn-glycerol 3-phosphate => dihydroxyacetone phosphate + FADH2"}
{"X":23625,"RHEA_ID":20732,"DIRECTION":"UN","MASTER_ID":20732,"ec":"1.8.4.16","compounds":"[protein]-dithiol + [thioredoxin]-disulfide = [protein]-disulfide + [thioredoxin]-dithiol"}
{"X":23626,"RHEA_ID":41260,"DIRECTION":"LR","MASTER_ID":41259,"metacyc":"RXN-17904","compounds":"L-tryptophan => (E)-3-(indol-3-yl)acrylate + NH4(+)"}
{"X":23627,"RHEA_ID":20734,"DIRECTION":"RL","MASTER_ID":20732,"metacyc":"RXN-20162","compounds":"[protein]-disulfide + [thioredoxin]-dithiol => [protein]-dithiol + [thioredoxin]-disulfide"}
{"X":23628,"RHEA_ID":20735,"compounds":"[protein]-dithiol + [thioredoxin]-disulfide <=> [protein]-disulfide + [thioredoxin]-dithiol"}
{"X":23629,"RHEA_ID":20736,"DIRECTION":"UN","MASTER_ID":20736,"ec":"2.3.1.29","compounds":"acetyl-CoA + glycine = (2S)-2-amino-3-oxobutanoate + CoA"}
{"X":23630,"RHEA_ID":41264,"compounds":"NAD(+) + prostaglandin A1 => 15-keto-prostaglandin A1 + H(+) + NADH"}
{"X":23631,"RHEA_ID":20738,"compounds":"(2S)-2-amino-3-oxobutanoate + CoA => acetyl-CoA + glycine"}
{"X":23632,"RHEA_ID":31292,"compounds":"(S)-malate + FAD + H(+) => FADH2 + oxaloacetate"}
{"X":23633,"RHEA_ID":20740,"DIRECTION":"UN","MASTER_ID":20740,"ec":"3.3.2.4","compounds":"H2O + trans-2,3-epoxysuccinate = (2R,3S)-tartrate"}
{"X":23634,"RHEA_ID":41268,"compounds":"H2O + N-(15Z-tetracosenoyl)-sphing-4-enine => (15Z)-tetracosenoate + sphing-4-enine"}
{"X":23635,"RHEA_ID":20742,"compounds":"(2R,3S)-tartrate => H2O + trans-2,3-epoxysuccinate"}
{"X":23636,"RHEA_ID":31296,"compounds":"(2E)-2-hydroxypenta-2,4-dienoate => 2-oxopent-4-enoate"}
{"X":23637,"RHEA_ID":20744,"DIRECTION":"UN","MASTER_ID":20744,"ec":"1.1.1.196","metacyc":"1.1.1.196-RXN","compounds":"NADP(+) + prostaglandin D2 = 15-dehydro-prostaglandin D2 + H(+) + NADPH"}
{"X":23638,"RHEA_ID":31298,"DIRECTION":"BI","MASTER_ID":31295,"ecocyc":"RXN-7282","metacyc":"RXN-7282","compounds":"(2E)-2-hydroxypenta-2,4-dienoate <=> 2-oxopent-4-enoate"}
{"X":23639,"RHEA_ID":20746,"compounds":"15-dehydro-prostaglandin D2 + H(+) + NADPH => NADP(+) + prostaglandin D2"}
{"X":23640,"RHEA_ID":31300,"compounds":"H2O + NAD(+) + perillyl aldehyde => 2 H(+) + NADH + perillate"}
{"X":23641,"RHEA_ID":20748,"DIRECTION":"UN","MASTER_ID":20748,"ec":"1.14.20.1","compounds":"2-oxoglutarate + O2 + penicillin N = CO2 + deacetoxycephalosporin C + H2O + succinate"}
{"X":23642,"RHEA_ID":41276,"compounds":"H2O + N-eicosanoyl-sphing-4-enine => eicosanoate + sphing-4-enine"}
{"X":23643,"RHEA_ID":20750,"compounds":"CO2 + deacetoxycephalosporin C + H2O + succinate => 2-oxoglutarate + O2 + penicillin N"}
{"X":23644,"RHEA_ID":31304,"compounds":"a reduced flavin + NAD(+) => an oxidized flavin + 2 H(+) + NADH"}
{"X":23645,"RHEA_ID":20752,"DIRECTION":"UN","MASTER_ID":20752,"ec":"1.16.1.5","compounds":"2 cob(II)alamin + H(+) + 2 H2O + NADP(+) = 2 aquacob(III)alamin + NADPH"}
{"X":23646,"RHEA_ID":20753,"compounds":"2 cob(II)alamin + H(+) + 2 H2O + NADP(+) => 2 aquacob(III)alamin + NADPH"}
{"X":23647,"RHEA_ID":20754,"compounds":"2 aquacob(III)alamin + NADPH => 2 cob(II)alamin + H(+) + 2 H2O + NADP(+)"}
{"X":23648,"RHEA_ID":20756,"DIRECTION":"UN","MASTER_ID":20756,"ec":"2.3.1.126","metacyc":"2.3.1.126-RXN","compounds":"caffeoyl-CoA + isocitrate = 2-caffeoylisocitrate + CoA"}
{"X":23649,"RHEA_ID":20757,"compounds":"caffeoyl-CoA + isocitrate => 2-caffeoylisocitrate + CoA"}
{"X":23650,"RHEA_ID":20758,"compounds":"2-caffeoylisocitrate + CoA => caffeoyl-CoA + isocitrate"}
{"X":23651,"RHEA_ID":31312,"compounds":"(2R)-3-phosphoglycerate + ADP-alpha-D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + ADP + H(+)"}
{"X":23652,"RHEA_ID":20760,"compounds":"AH2 + linalool + O2 = (6E)-8-hydroxylinalool + A + H2O"}
{"X":23653,"RHEA_ID":31314,"compounds":"(2R)-3-phosphoglycerate + ADP-alpha-D-glucose <=> (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + ADP + H(+)"}
{"X":23654,"RHEA_ID":20762,"compounds":"(6E)-8-hydroxylinalool + A + H2O => AH2 + linalool + O2"}
{"X":23655,"RHEA_ID":31316,"DIRECTION":"LR","MASTER_ID":31315,"metacyc":"RXN-12038","compounds":"(2R)-3-phosphoglycerate + GDP-D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP + H(+)"}
{"X":23656,"RHEA_ID":20764,"DIRECTION":"UN","MASTER_ID":20764,"ec":"2.1.3.1","compounds":"(S)-methylmalonyl-CoA + pyruvate = oxaloacetate + propanoyl-CoA"}
{"X":23657,"RHEA_ID":31318,"compounds":"(2R)-3-phosphoglycerate + GDP-D-glucose <=> (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP + H(+)"}
{"X":23658,"RHEA_ID":20766,"compounds":"oxaloacetate + propanoyl-CoA => (S)-methylmalonyl-CoA + pyruvate"}
{"X":23659,"RHEA_ID":31320,"DIRECTION":"LR","MASTER_ID":31319,"metacyc":"RXN-12041","compounds":"(2R)-3-phosphoglycerate + UDP-alpha-D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H(+) + UDP"}
{"X":23660,"RHEA_ID":20768,"DIRECTION":"UN","MASTER_ID":20768,"ec":"4.1.1.82","compounds":"3-phosphonopyruvate + H(+) = CO2 + phosphonoacetaldehyde"}
{"X":23661,"RHEA_ID":31322,"compounds":"(2R)-3-phosphoglycerate + UDP-alpha-D-glucose <=> (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H(+) + UDP"}
{"X":23662,"RHEA_ID":20770,"compounds":"CO2 + phosphonoacetaldehyde => 3-phosphonopyruvate + H(+)"}
{"X":23663,"RHEA_ID":31324,"DIRECTION":"LR","MASTER_ID":31323,"metacyc":"RXN-12029","compounds":"(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP-alpha-D-mannose => (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + GDP + H(+)"}
{"X":23664,"RHEA_ID":20772,"DIRECTION":"UN","MASTER_ID":20772,"ec":"2.5.1.9","compounds":"2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) = 5-amino-6-(D-ribitylamino)uracil + riboflavin"}
{"X":23665,"RHEA_ID":41300,"compounds":"H2O + N-(9Z-octadecenoyl)-sphing-4-enine => (9Z)-octadecenoate + sphing-4-enine"}
{"X":23666,"RHEA_ID":20774,"compounds":"5-amino-6-(D-ribitylamino)uracil + riboflavin => 2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+)"}
{"X":23667,"RHEA_ID":31328,"DIRECTION":"LR","MASTER_ID":31327,"metacyc":"RXN-11879","compounds":"1D-myo-inositol 3-phosphate + CDP-1L-myo-inositol => bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate + CMP + H(+)"}
{"X":23668,"RHEA_ID":20776,"DIRECTION":"UN","MASTER_ID":20776,"ec":"2.4.1.67","compounds":"alpha-D-galactosyl-(1->3)-1D-myo-inositol + raffinose = myo-inositol + stachyose"}
{"X":23669,"RHEA_ID":41304,"compounds":"H2O + N-(dodecanoyl)-4-hydroxysphinganine => 4-hydroxysphinganine + dodecanoate"}
{"X":23670,"RHEA_ID":20778,"compounds":"myo-inositol + stachyose => alpha-D-galactosyl-(1->3)-1D-myo-inositol + raffinose"}
{"X":23671,"RHEA_ID":31332,"DIRECTION":"LR","MASTER_ID":31331,"ecocyc":"RXN-8344","metacyc":"RXN-8344","compounds":"ATP + H(+) + molybdopterin => adenylyl-molybdopterin + diphosphate"}
{"X":23672,"RHEA_ID":20780,"DIRECTION":"UN","MASTER_ID":20780,"ec":"2.7.4.8","compounds":"ATP + GMP = ADP + GDP"}
{"X":23673,"RHEA_ID":31334,"compounds":"ATP + H(+) + molybdopterin <=> adenylyl-molybdopterin + diphosphate"}
{"X":23674,"RHEA_ID":20782,"compounds":"ADP + GDP => ATP + GMP"}
{"X":23675,"RHEA_ID":31336,"compounds":"CTP + H(+) + Mo-molybdopterin => diphosphate + Mo-molybdopterin cytosine dinucleotide"}
{"X":23676,"RHEA_ID":20784,"DIRECTION":"UN","MASTER_ID":20784,"ec":"3.2.2.19","compounds":"H2O + N(omega)-(ADP-D-ribosyl)-L-arginine = ADP-D-ribose + L-arginine"}
{"X":23677,"RHEA_ID":31338,"DIRECTION":"BI","MASTER_ID":31335,"ecocyc":"RXN0-6254","metacyc":"RXN0-6254","compounds":"CTP + H(+) + Mo-molybdopterin <=> diphosphate + Mo-molybdopterin cytosine dinucleotide"}
{"X":23678,"RHEA_ID":20786,"compounds":"ADP-D-ribose + L-arginine => H2O + N(omega)-(ADP-D-ribosyl)-L-arginine"}
{"X":23679,"RHEA_ID":31340,"DIRECTION":"LR","MASTER_ID":31339,"metacyc":"RXN-9776","compounds":"acetate + ATP + holo-[ACP] => acetyl-[ACP] + AMP + diphosphate"}
{"X":23680,"RHEA_ID":20788,"compounds":"NAD(+) + phosphate = ADP-D-ribose 1''-phosphate + H(+) + nicotinamide"}
{"X":23681,"RHEA_ID":41316,"compounds":"1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate"}
{"X":23682,"RHEA_ID":20790,"compounds":"ADP-D-ribose 1''-phosphate + H(+) + nicotinamide => NAD(+) + phosphate"}
{"X":23683,"RHEA_ID":20791,"compounds":"NAD(+) + phosphate <=> ADP-D-ribose 1''-phosphate + H(+) + nicotinamide"}
{"X":23684,"RHEA_ID":20792,"DIRECTION":"UN","MASTER_ID":20792,"ec":"6.1.1.6","compounds":"ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)"}
{"X":23685,"RHEA_ID":20793,"DIRECTION":"LR","MASTER_ID":20792,"ecocyc":"LYSINE--TRNA-LIGASE-RXN","metacyc":"LYSINE--TRNA-LIGASE-RXN","compounds":"ATP + L-lysine + tRNA(Lys) => AMP + diphosphate + L-lysyl-tRNA(Lys)"}
{"X":23686,"RHEA_ID":20794,"compounds":"AMP + diphosphate + L-lysyl-tRNA(Lys) => ATP + L-lysine + tRNA(Lys)"}
{"X":23687,"RHEA_ID":31348,"DIRECTION":"LR","MASTER_ID":31347,"metacyc":"RXN-11469","compounds":"(+)-abscisic acid D-glucopyranosyl ester + H2O => 2-cis-(+)-abscisate + beta-D-glucose + H(+)"}
{"X":23688,"RHEA_ID":20796,"DIRECTION":"UN","MASTER_ID":20796,"ec":"5.3.1.20","metacyc":"RIBOSE-ISOMERASE-RXN","compounds":"aldehydo-D-ribose = D-ribulose"}
{"X":23689,"RHEA_ID":20797,"compounds":"aldehydo-D-ribose => D-ribulose"}
{"X":23690,"RHEA_ID":31351,"DIRECTION":"UN","MASTER_ID":31351,"ec":"4.2.1.128","compounds":"lupan-3beta,20-diol = (S)-2,3-epoxysqualene + H2O"}
{"X":23691,"RHEA_ID":31352,"compounds":"lupan-3beta,20-diol => (S)-2,3-epoxysqualene + H2O"}
{"X":23692,"RHEA_ID":20800,"DIRECTION":"UN","MASTER_ID":20800,"ec":"2.4.1.175","compounds":"3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP"}
{"X":23693,"RHEA_ID":20801,"DIRECTION":"LR","MASTER_ID":20800,"metacyc":"RXN-16325","compounds":"3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine => 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP"}
{"X":23694,"RHEA_ID":31355,"DIRECTION":"UN","MASTER_ID":31355,"ec":"1.14.13.131","compounds":"dimethyl sulfide + H(+) + NADH + O2 = formaldehyde + H2O + methanethiol + NAD(+)"}
{"X":23695,"RHEA_ID":31356,"DIRECTION":"LR","MASTER_ID":31355,"metacyc":"RXN-9740","compounds":"dimethyl sulfide + H(+) + NADH + O2 => formaldehyde + H2O + methanethiol + NAD(+)"}
{"X":23696,"RHEA_ID":20804,"DIRECTION":"UN","MASTER_ID":20804,"ec":"1.2.1.27","compounds":"2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) = H(+) + hydrogencarbonate + NADH + propanoyl-CoA"}
{"X":23697,"RHEA_ID":31359,"DIRECTION":"UN","MASTER_ID":31359,"ec":"1.14.14.10","compounds":"FMNH2 + nitrilotriacetate + O2 = ammoniodiacetate + FMN + glyoxylate + H2O"}
{"X":23698,"RHEA_ID":20805,"DIRECTION":"LR","MASTER_ID":20804,"metacyc":"RXN-11213","compounds":"2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) => H(+) + hydrogencarbonate + NADH + propanoyl-CoA"}
{"X":23699,"RHEA_ID":20806,"compounds":"H(+) + hydrogencarbonate + NADH + propanoyl-CoA => 2-methyl-3-oxopropanoate + CoA + H2O + NAD(+)"}
{"X":23700,"RHEA_ID":41337,"DIRECTION":"LR","MASTER_ID":41336,"reactome":"R-HSA-2161950.2","compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate"}
{"X":23701,"RHEA_ID":20808,"DIRECTION":"UN","MASTER_ID":20808,"ec":"2.3.1.45","compounds":"acetyl-CoA + N-acetylneuraminate = CoA + N-acetyl-7-O-acetylneuraminate"}
{"X":23702,"RHEA_ID":20809,"compounds":"acetyl-CoA + N-acetylneuraminate => CoA + N-acetyl-7-O-acetylneuraminate"}
{"X":23703,"RHEA_ID":20810,"compounds":"CoA + N-acetyl-7-O-acetylneuraminate => acetyl-CoA + N-acetylneuraminate"}
{"X":23704,"RHEA_ID":31365,"compounds":"2 H(+) + NADPH + oxidized coenzyme F420-(gamma-Glu)(n) => NADP(+) + reduced coenzyme F420-(gamma-Glu)(n)"}
{"X":23705,"RHEA_ID":41342,"compounds":"10R-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate => (6Z,9Z,12Z)-octadecatrienoate + O2"}
{"X":23706,"RHEA_ID":20813,"compounds":"(3S)-citryl-CoA => acetyl-CoA + oxaloacetate"}
{"X":23707,"RHEA_ID":20814,"compounds":"acetyl-CoA + oxaloacetate => (3S)-citryl-CoA"}
{"X":23708,"RHEA_ID":31369,"compounds":"H2O + nitrate + 2 nitric oxide => 2 H(+) + 3 nitrite"}
{"X":23709,"RHEA_ID":20817,"compounds":"3alpha-hydroxyglycyrrhetinate + NADP(+) => 3-oxoglycyrrhetinate + H(+) + NADPH"}
{"X":23710,"RHEA_ID":20818,"compounds":"3-oxoglycyrrhetinate + H(+) + NADPH => 3alpha-hydroxyglycyrrhetinate + NADP(+)"}
{"X":23711,"RHEA_ID":31373,"compounds":"(2R,3S)-2,7-dihydroxy-4'-methoxyisoflavanone + H(+) + S-adenosyl-L-homocysteine => (2R,3S)-2,4',7-trihydroxyisoflavanone + S-adenosyl-L-methionine"}
{"X":23712,"RHEA_ID":41350,"compounds":"2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O"}
{"X":23713,"RHEA_ID":20821,"compounds":"choline sulfate + H2O => choline + H(+) + sulfate"}
{"X":23714,"RHEA_ID":20822,"compounds":"choline + H(+) + sulfate => choline sulfate + H2O"}
{"X":23715,"RHEA_ID":31377,"compounds":"1H-pyrrole + CO2 => H(+) + pyrrole-2-carboxylate"}
{"X":23716,"RHEA_ID":20825,"DIRECTION":"LR","MASTER_ID":20824,"macie":"M0209","metacyc":"ADENOSINE-KINASE-RXN","compounds":"adenosine + ATP => ADP + AMP + H(+)"}
{"X":23717,"RHEA_ID":20826,"compounds":"ADP + AMP + H(+) => adenosine + ATP"}
{"X":23718,"RHEA_ID":31381,"DIRECTION":"RL","MASTER_ID":31379,"metacyc":"RXN-12342","compounds":"1H-pyrrole + hydrogencarbonate => H2O + pyrrole-2-carboxylate"}
{"X":23719,"RHEA_ID":20829,"DIRECTION":"LR","MASTER_ID":20828,"ecocyc":"PHOSPHASERDECARB-RXN","metacyc":"PHOSPHASERDECARB-RXN","compounds":"1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2"}
{"X":23720,"RHEA_ID":20830,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2 => 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+)"}
{"X":23721,"RHEA_ID":41362,"compounds":"H(+) + hexadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":23722,"RHEA_ID":20833,"DIRECTION":"LR","MASTER_ID":20832,"metacyc":"3.6.3.37-RXN","compounds":"ATP + guanine(out) + H2O => ADP + guanine(in) + H(+) + phosphate"}
{"X":23723,"RHEA_ID":20834,"compounds":"ADP + guanine(in) + H(+) + phosphate => ATP + guanine(out) + H2O"}
{"X":23724,"RHEA_ID":20835,"compounds":"ATP + guanine(out) + H2O <=> ADP + guanine(in) + H(+) + phosphate"}
{"X":23725,"RHEA_ID":20836,"compounds":"all-trans-hexaprenyl diphosphate + isopentenyl diphosphate = all-trans-heptaprenyl diphosphate + diphosphate"}
{"X":23726,"RHEA_ID":20837,"DIRECTION":"LR","MASTER_ID":20836,"metacyc":"TRANS-HEXAPRENYLTRANSTRANSFERASE-RXN","compounds":"all-trans-hexaprenyl diphosphate + isopentenyl diphosphate => all-trans-heptaprenyl diphosphate + diphosphate"}
{"X":23727,"RHEA_ID":20838,"compounds":"all-trans-heptaprenyl diphosphate + diphosphate => all-trans-hexaprenyl diphosphate + isopentenyl diphosphate"}
{"X":23728,"RHEA_ID":31393,"compounds":"all-trans-4,4'-diapolycopene + 4 FADH2 => 15-cis-4,4'-diapophytoene + 4 FAD + 4 H(+)"}
{"X":23729,"RHEA_ID":20840,"DIRECTION":"UN","MASTER_ID":20840,"ec":"4.1.1.22","compounds":"H(+) + L-histidine = CO2 + histamine"}
{"X":23730,"RHEA_ID":20841,"DIRECTION":"LR","MASTER_ID":20840,"macie":"M0049","metacyc":"HISTIDINE-DECARBOXYLASE-RXN","reactome":"R-HSA-977301.1","compounds":"H(+) + L-histidine => CO2 + histamine"}
{"X":23731,"RHEA_ID":20842,"compounds":"CO2 + histamine => H(+) + L-histidine"}
{"X":23732,"RHEA_ID":31397,"compounds":"all-trans-4,4'-diapophytofluene + FADH2 => 15-cis-4,4'-diapophytoene + FAD + H(+)"}
{"X":23733,"RHEA_ID":41374,"compounds":"1-O-dodecyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-O-dodecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O"}
{"X":23734,"RHEA_ID":20845,"DIRECTION":"LR","MASTER_ID":20844,"macie":"M0223","metacyc":"PYRUVATE-CARBOXYLASE-RXN","compounds":"ATP + hydrogencarbonate + pyruvate => ADP + H(+) + oxaloacetate + phosphate"}
{"X":23735,"RHEA_ID":20846,"compounds":"ADP + H(+) + oxaloacetate + phosphate => ATP + hydrogencarbonate + pyruvate"}
{"X":23736,"RHEA_ID":31401,"compounds":"all-trans-4,4'-diapo-zeta-carotene + FADH2 => all-trans-4,4'-diapophytofluene + FAD + H(+)"}
{"X":23737,"RHEA_ID":20848,"DIRECTION":"UN","MASTER_ID":20848,"ec":"1.2.3.3","compounds":"H(+) + O2 + phosphate + pyruvate = acetyl phosphate + CO2 + H2O2"}
{"X":23738,"RHEA_ID":20849,"DIRECTION":"LR","MASTER_ID":20848,"macie":"M0274","metacyc":"1.2.3.3-RXN","compounds":"H(+) + O2 + phosphate + pyruvate => acetyl phosphate + CO2 + H2O2"}
{"X":23739,"RHEA_ID":20850,"compounds":"acetyl phosphate + CO2 + H2O2 => H(+) + O2 + phosphate + pyruvate"}
{"X":23740,"RHEA_ID":41382,"compounds":"4-methylphenol + H2O + NAD(+) => H(+) + NADH + O2 + toluene"}
{"X":23741,"RHEA_ID":20853,"DIRECTION":"LR","MASTER_ID":20852,"metacyc":"3.6.3.6-RXN","compounds":"ATP + H(+)(in) + H2O => ADP + 2 H(+)(out) + phosphate"}
{"X":23742,"RHEA_ID":20854,"compounds":"ADP + 2 H(+)(out) + phosphate => ATP + H(+)(in) + H2O"}
{"X":23743,"RHEA_ID":31409,"compounds":"all-trans-4,4'-diapolycopene + FADH2 => all-trans-4,4'-diaponeurosporene + FAD + H(+)"}
{"X":23744,"RHEA_ID":20856,"DIRECTION":"UN","MASTER_ID":20856,"ec":"3.5.1.23","compounds":"an N-acylsphing-4-enine + H2O = a fatty acid + sphing-4-enine"}
{"X":23745,"RHEA_ID":20857,"DIRECTION":"LR","MASTER_ID":20856,"metacyc":"CERAMIDASE-RXN","compounds":"an N-acylsphing-4-enine + H2O => a fatty acid + sphing-4-enine"}
{"X":23746,"RHEA_ID":20858,"compounds":"a fatty acid + sphing-4-enine => an N-acylsphing-4-enine + H2O"}
{"X":23747,"RHEA_ID":41390,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate => 1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O"}
{"X":23748,"RHEA_ID":20861,"DIRECTION":"LR","MASTER_ID":20860,"metacyc":"ISOPIPERITENOL-DEHYDROGENASE-RXN","compounds":"(1S,6R)-isopiperitenol + NAD(+) => (6R)-isopiperitenone + H(+) + NADH"}
{"X":23749,"RHEA_ID":20862,"compounds":"(6R)-isopiperitenone + H(+) + NADH => (1S,6R)-isopiperitenol + NAD(+)"}
{"X":23750,"RHEA_ID":31417,"compounds":"(+)-2-epi-prezizaene + diphosphate => (2Z,6E)-farnesyl diphosphate"}
{"X":23751,"RHEA_ID":31418,"compounds":"(2Z,6E)-farnesyl diphosphate <=> (+)-2-epi-prezizaene + diphosphate"}
{"X":23752,"RHEA_ID":20865,"compounds":"alpha,alpha-trehalose 6-phosphate + phosphate => beta-D-glucose 1-phosphate + D-glucose 6-phosphate"}
{"X":23753,"RHEA_ID":20866,"compounds":"beta-D-glucose 1-phosphate + D-glucose 6-phosphate => alpha,alpha-trehalose 6-phosphate + phosphate"}
{"X":23754,"RHEA_ID":31421,"compounds":"(-)-beta-curcumene + diphosphate => (2Z,6E)-farnesyl diphosphate"}
{"X":23755,"RHEA_ID":20868,"compounds":"alpha,alpha-trehalose + H2O = 2 D-glucose"}
{"X":23756,"RHEA_ID":31423,"compounds":"(2Z,6E)-farnesyl diphosphate = (-)-alpha-cedrene + diphosphate"}
{"X":23757,"RHEA_ID":20870,"compounds":"2 D-glucose => alpha,alpha-trehalose + H2O"}
{"X":23758,"RHEA_ID":31425,"compounds":"(-)-alpha-cedrene + diphosphate => (2Z,6E)-farnesyl diphosphate"}
{"X":23759,"RHEA_ID":20872,"DIRECTION":"UN","MASTER_ID":20872,"ec":"2.4.1.314","compounds":"(20S)-ginsenoside Rd + UDP-alpha-D-glucose = (20S)-ginsenoside Rb1 + H(+) + UDP"}
{"X":23760,"RHEA_ID":31427,"DIRECTION":"UN","MASTER_ID":31427,"ec":"4.2.3.81","compounds":"(2E,6E)-farnesyl diphosphate = (-)-exo-alpha-bergamotene + diphosphate"}
{"X":23761,"RHEA_ID":20874,"compounds":"(20S)-ginsenoside Rb1 + H(+) + UDP => (20S)-ginsenoside Rd + UDP-alpha-D-glucose"}
{"X":23762,"RHEA_ID":31429,"compounds":"(-)-exo-alpha-bergamotene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":23763,"RHEA_ID":20876,"DIRECTION":"UN","MASTER_ID":20876,"ec":"1.3.8.3","compounds":"(R)-2-benzylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (E)-2-benzylidenesuccinyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":23764,"RHEA_ID":20877,"DIRECTION":"LR","MASTER_ID":20876,"metacyc":"RXN-865","compounds":"(R)-2-benzylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (E)-2-benzylidenesuccinyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":23765,"RHEA_ID":31432,"DIRECTION":"LR","MASTER_ID":31431,"metacyc":"RXN-12494","compounds":"(2E,6E)-farnesyl diphosphate => (-)-beta-santalene + diphosphate"}
{"X":23766,"RHEA_ID":20879,"compounds":"(R)-2-benzylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (E)-2-benzylidenesuccinyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":23767,"RHEA_ID":20880,"DIRECTION":"UN","MASTER_ID":20880,"ec":"1.1.1.66","metacyc":"OMEGA-HYDROXYDECANOATE-DEHYDROGENASE-RXN","compounds":"10-hydroxydecanoate + NAD(+) = 10-oxodecanoate + H(+) + NADH"}
{"X":23768,"RHEA_ID":20881,"compounds":"10-hydroxydecanoate + NAD(+) => 10-oxodecanoate + H(+) + NADH"}
{"X":23769,"RHEA_ID":31436,"DIRECTION":"LR","MASTER_ID":31435,"metacyc":"RXN-12493","compounds":"(2E,6E)-farnesyl diphosphate => (+)-alpha-santalene + diphosphate"}
{"X":23770,"RHEA_ID":31437,"compounds":"(+)-alpha-santalene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":23771,"RHEA_ID":20884,"DIRECTION":"UN","MASTER_ID":20884,"ec":"1.4.1.7","metacyc":"SERINE-DEHYDROGENASE-RXN","compounds":"H2O + L-serine + NAD(+) = 3-hydroxypyruvate + H(+) + NADH + NH4(+)"}
{"X":23772,"RHEA_ID":20885,"compounds":"H2O + L-serine + NAD(+) => 3-hydroxypyruvate + H(+) + NADH + NH4(+)"}
{"X":23773,"RHEA_ID":20886,"compounds":"3-hydroxypyruvate + H(+) + NADH + NH4(+) => H2O + L-serine + NAD(+)"}
{"X":23774,"RHEA_ID":31441,"compounds":"alpha-longipinene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":23775,"RHEA_ID":20888,"DIRECTION":"UN","MASTER_ID":20888,"ec":"3.1.2.4","compounds":"3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)"}
{"X":23776,"RHEA_ID":20889,"DIRECTION":"LR","MASTER_ID":20888,"macie":"M0345","metacyc":"3-HYDROXYISOBUTYRYL-COA-HYDROLASE-RXN","compounds":"3-hydroxy-2-methylpropanoyl-CoA + H2O => 3-hydroxy-2-methylpropanoate + CoA + H(+)"}
{"X":23777,"RHEA_ID":31444,"DIRECTION":"LR","MASTER_ID":31443,"ecocyc":"RXN0-6541","compounds":"ATP + D-sedoheptulose 7-phosphate => ADP + H(+) + sedoheptulose 1,7-bisphosphate"}
{"X":23778,"RHEA_ID":31445,"compounds":"ADP + H(+) + sedoheptulose 1,7-bisphosphate => ATP + D-sedoheptulose 7-phosphate"}
{"X":23779,"RHEA_ID":20892,"DIRECTION":"UN","MASTER_ID":20892,"ec":"2.3.1.19","compounds":"butanoyl-CoA + phosphate = butanoyl phosphate + CoA"}
{"X":23780,"RHEA_ID":20893,"compounds":"butanoyl-CoA + phosphate => butanoyl phosphate + CoA"}
{"X":23781,"RHEA_ID":20894,"compounds":"butanoyl phosphate + CoA => butanoyl-CoA + phosphate"}
{"X":23782,"RHEA_ID":31449,"compounds":"5-aminopentanoate + CO2 + H2O => 6-amino-2-oxohexanoate + H2O2"}
{"X":23783,"RHEA_ID":20896,"DIRECTION":"UN","MASTER_ID":20896,"ec":"6.3.4.6","compounds":"ATP + hydrogencarbonate + urea = ADP + H(+) + phosphate + urea-1-carboxylate"}
{"X":23784,"RHEA_ID":20897,"DIRECTION":"LR","MASTER_ID":20896,"metacyc":"UREA-CARBOXYLASE-RXN","compounds":"ATP + hydrogencarbonate + urea => ADP + H(+) + phosphate + urea-1-carboxylate"}
{"X":23785,"RHEA_ID":20898,"compounds":"ADP + H(+) + phosphate + urea-1-carboxylate => ATP + hydrogencarbonate + urea"}
{"X":23786,"RHEA_ID":31453,"compounds":"a cardiolipin + glycerol => 2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)"}
{"X":23787,"RHEA_ID":20900,"DIRECTION":"UN","MASTER_ID":20900,"ec":"3.5.1.58","compounds":"H(+) + H2O + N-benzyloxycarbonylglycine = benzyl alcohol + CO2 + glycine"}
{"X":23788,"RHEA_ID":20901,"DIRECTION":"LR","MASTER_ID":20900,"metacyc":"N-BENZYLOXYCARBONYLGLYCINE-HYDROLASE-RXN","compounds":"H(+) + H2O + N-benzyloxycarbonylglycine => benzyl alcohol + CO2 + glycine"}
{"X":23789,"RHEA_ID":31456,"compounds":"NAD(+) + reduced riboflavin => 2 H(+) + NADH + riboflavin"}
{"X":23790,"RHEA_ID":31457,"DIRECTION":"RL","MASTER_ID":31455,"ecocyc":"RXN-12445","metacyc":"RXN-12445","compounds":"2 H(+) + NADH + riboflavin => NAD(+) + reduced riboflavin"}
{"X":23791,"RHEA_ID":20904,"DIRECTION":"UN","MASTER_ID":20904,"ec":"4.4.1.23","compounds":"(2S)-2-hydroxypropyl-coenzyme M = (S)-1,2-epoxypropane + coenzyme M"}
{"X":23792,"RHEA_ID":20905,"compounds":"(2S)-2-hydroxypropyl-coenzyme M => (S)-1,2-epoxypropane + coenzyme M"}
{"X":23793,"RHEA_ID":31460,"DIRECTION":"LR","MASTER_ID":31459,"metacyc":"RXN-12609","compounds":"2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate => 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate"}
{"X":23794,"RHEA_ID":31461,"compounds":"2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate => 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate"}
{"X":23795,"RHEA_ID":20908,"DIRECTION":"UN","MASTER_ID":20908,"ec":"2.4.1.225","compounds":"3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n+1)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP"}
{"X":23796,"RHEA_ID":20909,"DIRECTION":"LR","MASTER_ID":20908,"metacyc":"2.4.1.225-RXN","compounds":"3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-alpha-D-glucuronate => 3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n+1)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP"}
{"X":23797,"RHEA_ID":31464,"DIRECTION":"LR","MASTER_ID":31463,"metacyc":"RXN-8471","compounds":"crocetin + UDP-alpha-D-glucose => beta-D-glucosyl crocetin + UDP"}
{"X":23798,"RHEA_ID":31465,"compounds":"beta-D-glucosyl crocetin + UDP => crocetin + UDP-alpha-D-glucose"}
{"X":23799,"RHEA_ID":20912,"DIRECTION":"UN","MASTER_ID":20912,"ec":"4.2.3.17","compounds":"all-trans-geranylgeranyl diphosphate = diphosphate + taxa-4,11-diene"}
{"X":23800,"RHEA_ID":20913,"compounds":"all-trans-geranylgeranyl diphosphate => diphosphate + taxa-4,11-diene"}
{"X":23801,"RHEA_ID":31468,"DIRECTION":"LR","MASTER_ID":31467,"metacyc":"RXN-8473","compounds":"beta-D-glucosyl crocetin + UDP-alpha-D-glucose => bis(beta-D-glucosyl) crocetin + UDP"}
{"X":23802,"RHEA_ID":31469,"compounds":"bis(beta-D-glucosyl) crocetin + UDP => beta-D-glucosyl crocetin + UDP-alpha-D-glucose"}
{"X":23803,"RHEA_ID":20916,"DIRECTION":"UN","MASTER_ID":20916,"ec":"4.4.1.10","compounds":"L-cysteine + sulfite = hydrogen sulfide + L-cysteate"}
{"X":23804,"RHEA_ID":20917,"DIRECTION":"LR","MASTER_ID":20916,"metacyc":"CYSTEINE-LYASE-RXN","compounds":"L-cysteine + sulfite => hydrogen sulfide + L-cysteate"}
{"X":23805,"RHEA_ID":20918,"compounds":"hydrogen sulfide + L-cysteate => L-cysteine + sulfite"}
{"X":23806,"RHEA_ID":31473,"compounds":"beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP => beta-D-gentiobiosyl crocetin + UDP-alpha-D-glucose"}
{"X":23807,"RHEA_ID":20920,"DIRECTION":"UN","MASTER_ID":20920,"ec":"1.14.13.20","compounds":"2,4-dichlorophenol + H(+) + NADPH + O2 = 3,5-dichlorocatechol + H2O + NADP(+)"}
{"X":23808,"RHEA_ID":20921,"DIRECTION":"LR","MASTER_ID":20920,"metacyc":"24-DICHLOROPHENOL-6-MONOOXYGENASE-RXN","compounds":"2,4-dichlorophenol + H(+) + NADPH + O2 => 3,5-dichlorocatechol + H2O + NADP(+)"}
{"X":23809,"RHEA_ID":31476,"DIRECTION":"LR","MASTER_ID":31475,"metacyc":"RXN-8086","compounds":"soyasapogenol B + UDP-alpha-D-glucuronate => H(+) + soyasapogenol B 3-O-beta-D-glucuronate + UDP"}
{"X":23810,"RHEA_ID":31477,"compounds":"H(+) + soyasapogenol B 3-O-beta-D-glucuronate + UDP => soyasapogenol B + UDP-alpha-D-glucuronate"}
{"X":23811,"RHEA_ID":20924,"DIRECTION":"UN","MASTER_ID":20924,"ec":"4.3.2.5","compounds":"a [peptide]-C-terminal (2S)-2-hydroxyglycine = a [peptide]-C-terminal amide + glyoxylate"}
{"X":23812,"RHEA_ID":20925,"compounds":"a [peptide]-C-terminal (2S)-2-hydroxyglycine => a [peptide]-C-terminal amide + glyoxylate"}
{"X":23813,"RHEA_ID":31480,"compounds":"soyasapogenol A + UDP-alpha-D-glucuronate => H(+) + soyasapogenol A 3-O-beta-D-glucuronate + UDP"}
{"X":23814,"RHEA_ID":20928,"DIRECTION":"UN","MASTER_ID":20928,"ec":"1.8.5.9","compounds":"[DsbA protein]-dithiol + a quinone = [DsbA protein]-disulfide + a quinol"}
{"X":23815,"RHEA_ID":20929,"DIRECTION":"LR","MASTER_ID":20928,"metacyc":"RXN-20159","compounds":"[DsbA protein]-dithiol + a quinone => [DsbA protein]-disulfide + a quinol"}
{"X":23816,"RHEA_ID":31484,"compounds":"soyasapogenol E + UDP-alpha-D-glucuronate => H(+) + soyasapogenol E 3-O-beta-D-glucuronate + UDP"}
{"X":23817,"RHEA_ID":20932,"DIRECTION":"UN","MASTER_ID":20932,"ec":"4.1.2.2","metacyc":"KETOTETROSE-PHOSPHATE-ALDOLASE-RXN","compounds":"L-erythrulose 1-phosphate = dihydroxyacetone phosphate + formaldehyde"}
{"X":23818,"RHEA_ID":20933,"compounds":"L-erythrulose 1-phosphate => dihydroxyacetone phosphate + formaldehyde"}
{"X":23819,"RHEA_ID":31488,"DIRECTION":"LR","MASTER_ID":31487,"metacyc":"RXN-12319","compounds":"soyasapogenol B 3-O-beta-D-glucuronate + UDP-alpha-D-galactose => H(+) + soyasaponin III + UDP"}
{"X":23820,"RHEA_ID":31489,"compounds":"H(+) + soyasaponin III + UDP => soyasapogenol B 3-O-beta-D-glucuronate + UDP-alpha-D-galactose"}
{"X":23821,"RHEA_ID":20936,"DIRECTION":"UN","MASTER_ID":20936,"ec":"4.2.1.9","compounds":"2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O"}
{"X":23822,"RHEA_ID":20937,"compounds":"2,3-dihydroxy-3-methylbutanoate => 3-methyl-2-oxobutanoate + H2O"}
{"X":23823,"RHEA_ID":20938,"compounds":"3-methyl-2-oxobutanoate + H2O => 2,3-dihydroxy-3-methylbutanoate"}
{"X":23824,"RHEA_ID":31493,"compounds":"H(+) + soyasaponin I + UDP => soyasaponin III + UDP-beta-L-rhamnose"}
{"X":23825,"RHEA_ID":20940,"DIRECTION":"UN","MASTER_ID":20940,"ec":"2.7.1.159","compounds":"1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)"}
{"X":23826,"RHEA_ID":20941,"DIRECTION":"LR","MASTER_ID":20940,"metacyc":"2.7.1.133-RXN","reactome":"R-HSA-1855197.2","compounds":"1D-myo-inositol 1,3,4-trisphosphate + ATP => 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)"}
{"X":23827,"RHEA_ID":20941,"DIRECTION":"LR","MASTER_ID":20940,"metacyc":"2.7.1.133-RXN","reactome":"R-HSA-2267372.3","compounds":"1D-myo-inositol 1,3,4-trisphosphate + ATP => 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)"}
{"X":23828,"RHEA_ID":20942,"compounds":"1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+) => 1D-myo-inositol 1,3,4-trisphosphate + ATP"}
{"X":23829,"RHEA_ID":51440,"compounds":"(9Z,12Z,15Z)-octadecatrienoate + O2 = (11S)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate"}
{"X":23830,"RHEA_ID":20944,"DIRECTION":"UN","MASTER_ID":20944,"ec":"2.1.1.160","compounds":"S-adenosyl-L-methionine + theobromine = caffeine + H(+) + S-adenosyl-L-homocysteine"}
{"X":23831,"RHEA_ID":20945,"DIRECTION":"LR","MASTER_ID":20944,"metacyc":"RXN-7599","compounds":"S-adenosyl-L-methionine + theobromine => caffeine + H(+) + S-adenosyl-L-homocysteine"}
{"X":23832,"RHEA_ID":20946,"compounds":"caffeine + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + theobromine"}
{"X":23833,"RHEA_ID":51444,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-leucine = H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-leucine"}
{"X":23834,"RHEA_ID":20948,"DIRECTION":"UN","MASTER_ID":20948,"ec":"4.1.1.79","compounds":"3-sulfopyruvate + H(+) = CO2 + sulfoacetaldehyde"}
{"X":23835,"RHEA_ID":20949,"DIRECTION":"LR","MASTER_ID":20948,"metacyc":"R231-RXN","compounds":"3-sulfopyruvate + H(+) => CO2 + sulfoacetaldehyde"}
{"X":23836,"RHEA_ID":20950,"compounds":"CO2 + sulfoacetaldehyde => 3-sulfopyruvate + H(+)"}
{"X":23837,"RHEA_ID":31505,"compounds":"4,6-Me(COOH)C-beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-diphospho-di-trans,octa-cis-undecaprenol + phosphate => beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-diphospho-di-trans,octa-cis-undecaprenol + phosphoenolpyruvate"}
{"X":23838,"RHEA_ID":20952,"DIRECTION":"UN","MASTER_ID":20952,"ec":"2.4.1.188","compounds":"N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UDP-alpha-D-glucose = beta-D-glucosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP"}
{"X":23839,"RHEA_ID":20953,"DIRECTION":"LR","MASTER_ID":20952,"metacyc":"2.4.1.188-RXN","compounds":"N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UDP-alpha-D-glucose => beta-D-glucosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP"}
{"X":23840,"RHEA_ID":20954,"compounds":"beta-D-glucosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UDP-alpha-D-glucose"}
{"X":23841,"RHEA_ID":41486,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine"}
{"X":23842,"RHEA_ID":20956,"DIRECTION":"UN","MASTER_ID":20956,"ec":"6.2.1.30","compounds":"2-phenylacetate + ATP + CoA = AMP + diphosphate + phenylacetyl-CoA"}
{"X":23843,"RHEA_ID":20957,"DIRECTION":"LR","MASTER_ID":20956,"ecocyc":"PHENYLACETATE--COA-LIGASE-RXN","metacyc":"RXN-10819","compounds":"2-phenylacetate + ATP + CoA => AMP + diphosphate + phenylacetyl-CoA"}
{"X":23844,"RHEA_ID":20958,"compounds":"AMP + diphosphate + phenylacetyl-CoA => 2-phenylacetate + ATP + CoA"}
{"X":23845,"RHEA_ID":41490,"compounds":"1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine"}
{"X":23846,"RHEA_ID":20960,"DIRECTION":"UN","MASTER_ID":20960,"ec":"3.1.3.26","compounds":"1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,3,5,6-pentakisphosphate + phosphate"}
{"X":23847,"RHEA_ID":20961,"DIRECTION":"LR","MASTER_ID":20960,"metacyc":"RXN-7241","compounds":"1D-myo-inositol hexakisphosphate + H2O => 1D-myo-inositol 1,2,3,5,6-pentakisphosphate + phosphate"}
{"X":23848,"RHEA_ID":20962,"compounds":"1D-myo-inositol 1,2,3,5,6-pentakisphosphate + phosphate => 1D-myo-inositol hexakisphosphate + H2O"}
{"X":23849,"RHEA_ID":41494,"compounds":"1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine"}
{"X":23850,"RHEA_ID":20964,"DIRECTION":"UN","MASTER_ID":20964,"ec":"2.6.1.7","compounds":"2-oxoglutarate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate"}
{"X":23851,"RHEA_ID":20965,"DIRECTION":"LR","MASTER_ID":20964,"ecocyc":"2.6.1.7-RXN","metacyc":"2.6.1.7-RXN","reactome":"R-HSA-893583.1","compounds":"2-oxoglutarate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate"}
{"X":23852,"RHEA_ID":20966,"compounds":"4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate => 2-oxoglutarate + L-kynurenine"}
{"X":23853,"RHEA_ID":41498,"compounds":"1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine => 1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine"}
{"X":23854,"RHEA_ID":20968,"DIRECTION":"UN","MASTER_ID":20968,"ec":"4.2.1.25","compounds":"L-arabinonate = 2-dehydro-3-deoxy-L-arabinonate + H2O"}
{"X":23855,"RHEA_ID":20969,"DIRECTION":"LR","MASTER_ID":20968,"metacyc":"L-ARABINONATE-DEHYDRATASE-RXN","compounds":"L-arabinonate => 2-dehydro-3-deoxy-L-arabinonate + H2O"}
{"X":23856,"RHEA_ID":20970,"compounds":"2-dehydro-3-deoxy-L-arabinonate + H2O => L-arabinonate"}
{"X":23857,"RHEA_ID":31525,"compounds":"3 CO2 + ethene + H2O => 2-oxoglutarate + 2 H(+) + O2"}
{"X":23858,"RHEA_ID":20972,"DIRECTION":"UN","MASTER_ID":20972,"ec":"2.3.1.148","metacyc":"2.3.1.148-RXN","compounds":"1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine = 1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine"}
{"X":23859,"RHEA_ID":20973,"compounds":"1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine => 1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine"}
{"X":23860,"RHEA_ID":20974,"compounds":"1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine => 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine"}
{"X":23861,"RHEA_ID":31529,"compounds":"(S)-1-pyrroline-5-carboxylate + guanidine + H(+) + H2O => N(omega)-hydroxy-L-arginine"}
{"X":23862,"RHEA_ID":20976,"DIRECTION":"UN","MASTER_ID":20976,"ec":"1.7.3.1","compounds":"a primary nitroalkane + H2O + O2 = an aldehyde + H(+) + H2O2 + nitrite"}
{"X":23863,"RHEA_ID":20977,"DIRECTION":"LR","MASTER_ID":20976,"metacyc":"RXN-11045","compounds":"a primary nitroalkane + H2O + O2 => an aldehyde + H(+) + H2O2 + nitrite"}
{"X":23864,"RHEA_ID":20978,"compounds":"an aldehyde + H(+) + H2O2 + nitrite => a primary nitroalkane + H2O + O2"}
{"X":23865,"RHEA_ID":31533,"compounds":"CO2 + N(omega)-hydroxy-L-arginine + succinate => 2-oxoglutarate + L-arginine + O2"}
{"X":23866,"RHEA_ID":20980,"DIRECTION":"UN","MASTER_ID":20980,"ec":"1.3.3.5","compounds":"2 bilirubin IXalpha + O2 = 2 biliverdin IXalpha + 2 H2O"}
{"X":23867,"RHEA_ID":20981,"DIRECTION":"LR","MASTER_ID":20980,"metacyc":"BILIRUBIN-OXIDASE-RXN","compounds":"2 bilirubin IXalpha + O2 => 2 biliverdin IXalpha + 2 H2O"}
{"X":23868,"RHEA_ID":20982,"compounds":"2 biliverdin IXalpha + 2 H2O => 2 bilirubin IXalpha + O2"}
{"X":23869,"RHEA_ID":31537,"compounds":"(S)-1-pyrroline-5-carboxylate + CO2 + guanidine + H(+) + H2O + succinate => 2-oxoglutarate + L-arginine + O2"}
{"X":23870,"RHEA_ID":20984,"DIRECTION":"UN","MASTER_ID":20984,"ec":"3.1.4.41","compounds":"H2O + sphingomyelin = choline + H(+) + N-acylsphing-4-enine 1-phosphate"}
{"X":23871,"RHEA_ID":20985,"compounds":"H2O + sphingomyelin => choline + H(+) + N-acylsphing-4-enine 1-phosphate"}
{"X":23872,"RHEA_ID":20986,"compounds":"choline + H(+) + N-acylsphing-4-enine 1-phosphate => H2O + sphingomyelin"}
{"X":23873,"RHEA_ID":31541,"compounds":"(2S)-sakuranetin + H(+) + S-adenosyl-L-homocysteine => (S)-naringenin + S-adenosyl-L-methionine"}
{"X":23874,"RHEA_ID":20988,"compounds":"ATP + 2 H2O = AMP + 2 H(+) + 2 phosphate"}
{"X":23875,"RHEA_ID":20989,"compounds":"ATP + 2 H2O => AMP + 2 H(+) + 2 phosphate"}
{"X":23876,"RHEA_ID":20990,"compounds":"AMP + 2 H(+) + 2 phosphate => ATP + 2 H2O"}
{"X":23877,"RHEA_ID":41524,"DIRECTION":"UN","MASTER_ID":41524,"ec":"2.3.1.233","compounds":"5 H(+) + 5 malonyl-CoA = 5 CO2 + 5 CoA + H2O + naphthalene-1,3,6,8-tetrol"}
{"X":23878,"RHEA_ID":20992,"DIRECTION":"UN","MASTER_ID":20992,"ec":"2.1.1.94","compounds":"16-hydroxytabersonine + S-adenosyl-L-methionine = 16-methoxytabersonine + H(+) + S-adenosyl-L-homocysteine"}
{"X":23879,"RHEA_ID":20993,"DIRECTION":"LR","MASTER_ID":20992,"metacyc":"2.1.1.94-RXN","compounds":"16-hydroxytabersonine + S-adenosyl-L-methionine => 16-methoxytabersonine + H(+) + S-adenosyl-L-homocysteine"}
{"X":23880,"RHEA_ID":20994,"compounds":"16-methoxytabersonine + H(+) + S-adenosyl-L-homocysteine => 16-hydroxytabersonine + S-adenosyl-L-methionine"}
{"X":23881,"RHEA_ID":31549,"compounds":"15-cis-4,4'-diapophytoene + 2 diphosphate => 2 (2E,6E)-farnesyl diphosphate"}
{"X":23882,"RHEA_ID":20996,"DIRECTION":"UN","MASTER_ID":20996,"ec":"3.5.99.5","compounds":"(2Z,4E)-2-aminomuconate + H2O = (3E)-2-oxohex-3-enedioate + NH4(+)"}
{"X":23883,"RHEA_ID":20997,"DIRECTION":"LR","MASTER_ID":20996,"metacyc":"3.5.99.5-RXN","compounds":"(2Z,4E)-2-aminomuconate + H2O => (3E)-2-oxohex-3-enedioate + NH4(+)"}
{"X":23884,"RHEA_ID":20998,"compounds":"(3E)-2-oxohex-3-enedioate + NH4(+) => (2Z,4E)-2-aminomuconate + H2O"}
{"X":23885,"RHEA_ID":31553,"compounds":"15-cis-4,4'-diapophytoene + diphosphate => presqualene diphosphate"}
{"X":23886,"RHEA_ID":21000,"DIRECTION":"UN","MASTER_ID":21000,"ec":"1.97.1.2","compounds":"1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene = 1,2,3,5-tetrahydroxybenzene + 1,3,5-trihydroxybenzene"}
{"X":23887,"RHEA_ID":21001,"DIRECTION":"LR","MASTER_ID":21000,"metacyc":"1.97.1.2-RXN","compounds":"1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene => 1,2,3,5-tetrahydroxybenzene + 1,3,5-trihydroxybenzene"}
{"X":23888,"RHEA_ID":31556,"compounds":"(5S)-5-amino-3-oxo-hexanoate + acetyl-CoA => (3S)-3-aminobutanoyl-CoA + acetoacetate"}
{"X":23889,"RHEA_ID":31557,"compounds":"(3S)-3-aminobutanoyl-CoA + acetoacetate => (5S)-5-amino-3-oxo-hexanoate + acetyl-CoA"}
{"X":23890,"RHEA_ID":21004,"DIRECTION":"UN","MASTER_ID":21004,"ec":"1.1.99.27","metacyc":"1.1.99.27-RXN","compounds":"(R)-pantolactone + A = 2-dehydropantolactone + AH2"}
{"X":23891,"RHEA_ID":21005,"compounds":"(R)-pantolactone + A => 2-dehydropantolactone + AH2"}
{"X":23892,"RHEA_ID":31560,"DIRECTION":"LR","MASTER_ID":31559,"metacyc":"RXN-1884","compounds":"L-galactose + NAD(+) => H(+) + L-galactono-1,4-lactone + NADH"}
{"X":23893,"RHEA_ID":31561,"compounds":"H(+) + L-galactono-1,4-lactone + NADH => L-galactose + NAD(+)"}
{"X":23894,"RHEA_ID":21008,"DIRECTION":"UN","MASTER_ID":21008,"ec":"1.1.1.229","metacyc":"1.1.1.229-RXN","compounds":"diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP(+) = diethyl 2-methyl-3-oxosuccinate + H(+) + NADPH"}
{"X":23895,"RHEA_ID":21009,"compounds":"diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP(+) => diethyl 2-methyl-3-oxosuccinate + H(+) + NADPH"}
{"X":23896,"RHEA_ID":31564,"DIRECTION":"LR","MASTER_ID":31563,"metacyc":"RXN-12825","reactome":"R-HSA-266046.3","compounds":"H2O + leukotriene C4 => L-glutamate + leukotriene D4"}
{"X":23897,"RHEA_ID":31565,"compounds":"L-glutamate + leukotriene D4 => H2O + leukotriene C4"}
{"X":23898,"RHEA_ID":21012,"DIRECTION":"UN","MASTER_ID":21012,"ec":"2.4.1.70","compounds":"4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine = 4-O-([2-N-acetyl-alpha-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP"}
{"X":23899,"RHEA_ID":21013,"DIRECTION":"LR","MASTER_ID":21012,"metacyc":"2.4.1.53-RXN","compounds":"4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine => 4-O-([2-N-acetyl-alpha-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP"}
{"X":23900,"RHEA_ID":31568,"compounds":"bisphenol A + H(+) + NADH + O2 => 2,2-bis(4-hydroxyphenyl)-1-propanol + H2O + NAD(+)"}
{"X":23901,"RHEA_ID":31569,"compounds":"2,2-bis(4-hydroxyphenyl)-1-propanol + H2O + NAD(+) => bisphenol A + H(+) + NADH + O2"}
{"X":23902,"RHEA_ID":21016,"DIRECTION":"UN","MASTER_ID":21016,"ec":"3.5.1.38","compounds":"H2O + L-asparagine = L-aspartate + NH4(+)"}
{"X":23903,"RHEA_ID":31572,"DIRECTION":"LR","MASTER_ID":31571,"metacyc":"RXN-12763","compounds":"1-hydroxy-2-naphthoate + 2 H(+) + NADPH + O2 => CO2 + H2O + NADP(+) + naphthalene-1,2-diol"}
{"X":23904,"RHEA_ID":21017,"DIRECTION":"LR","MASTER_ID":21016,"ecocyc":"ASPARAGHYD-RXN","macie":"M0029","metacyc":"ASPARAGHYD-RXN","reactome":"R-HSA-6797627.1","compounds":"H2O + L-asparagine => L-aspartate + NH4(+)"}
{"X":23905,"RHEA_ID":21018,"compounds":"L-aspartate + NH4(+) => H2O + L-asparagine"}
{"X":23906,"RHEA_ID":31575,"DIRECTION":"UN","MASTER_ID":31575,"ec":"3.6.1.55","compounds":"8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate + H(+)"}
{"X":23907,"RHEA_ID":31576,"DIRECTION":"LR","MASTER_ID":31575,"reactome":"R-HSA-2395869.3","compounds":"8-oxo-dGTP + H2O => 8-oxo-dGMP + diphosphate + H(+)"}
{"X":23908,"RHEA_ID":21021,"DIRECTION":"LR","MASTER_ID":21020,"ecocyc":"CHORISMATE-SYNTHASE-RXN","metacyc":"CHORISMATE-SYNTHASE-RXN","compounds":"5-O-(1-carboxyvinyl)-3-phosphoshikimate => chorismate + phosphate"}
{"X":23909,"RHEA_ID":21022,"compounds":"chorismate + phosphate => 5-O-(1-carboxyvinyl)-3-phosphoshikimate"}
{"X":23910,"RHEA_ID":31578,"compounds":"8-oxo-dGTP + H2O <=> 8-oxo-dGMP + diphosphate + H(+)"}
{"X":23911,"RHEA_ID":31579,"DIRECTION":"UN","MASTER_ID":31579,"ec":"5.4.4.5","compounds":"(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate = (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate"}
{"X":23912,"RHEA_ID":21025,"compounds":"CoA + glyoxylate + NADP(+) => H(+) + NADPH + oxalyl-CoA"}
{"X":23913,"RHEA_ID":21026,"compounds":"H(+) + NADPH + oxalyl-CoA => CoA + glyoxylate + NADP(+)"}
{"X":23914,"RHEA_ID":41562,"compounds":"(3S)-3-amino-3-(3-chloro-4,5-dihydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FAD + H(+) + H2O => (3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FADH2 + O2"}
{"X":23915,"RHEA_ID":31583,"DIRECTION":"UN","MASTER_ID":31583,"ec":"3.6.1.56","compounds":"2-hydroxy-dATP + H2O = 2-hydroxy-dAMP + diphosphate + H(+)"}
{"X":23916,"RHEA_ID":21029,"compounds":"acetyl-CoA + an N-terminal L-alpha-aminoacyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-alpha-aminoacyl-[protein]"}
{"X":23917,"RHEA_ID":21030,"compounds":"CoA + H(+) + N-terminal N(alpha)-acetyl-L-alpha-aminoacyl-[protein] => acetyl-CoA + an N-terminal L-alpha-aminoacyl-[protein]"}
{"X":23918,"RHEA_ID":21031,"compounds":"acetyl-CoA + an N-terminal L-alpha-aminoacyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-alpha-aminoacyl-[protein]"}
{"X":23919,"RHEA_ID":21032,"DIRECTION":"UN","MASTER_ID":21032,"ec":"2.4.1.17","compounds":"glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP"}
{"X":23920,"RHEA_ID":21033,"DIRECTION":"LR","MASTER_ID":21032,"metacyc":"UDP-GLUCURONOSYLTRANSFERASE-RXN","compounds":"glucuronate acceptor + UDP-alpha-D-glucuronate => acceptor beta-D-glucuronoside + H(+) + UDP"}
{"X":23921,"RHEA_ID":21034,"compounds":"acceptor beta-D-glucuronoside + H(+) + UDP => glucuronate acceptor + UDP-alpha-D-glucuronate"}
{"X":23922,"RHEA_ID":41570,"compounds":"aclacinomycin S + dTDP + H(+) => aclacinomycin T + dTDP-2-deoxy-beta-L-fucose"}
{"X":23923,"RHEA_ID":31591,"compounds":"(Z)-3-ureidoacrylate peracid + H2O = (Z)-3-aminoperacrylic acid + carbamate + H(+)"}
{"X":23924,"RHEA_ID":21037,"DIRECTION":"LR","MASTER_ID":21036,"reactome":"R-HSA-73916.4","compounds":"2 acetyl-CoA => acetoacetyl-CoA + CoA"}
{"X":23925,"RHEA_ID":21037,"DIRECTION":"LR","MASTER_ID":21036,"reactome":"R-HSA-8848215.2","compounds":"2 acetyl-CoA => acetoacetyl-CoA + CoA"}
{"X":23926,"RHEA_ID":21038,"DIRECTION":"RL","MASTER_ID":21036,"reactome":"R-HSA-74181.3","compounds":"acetoacetyl-CoA + CoA => 2 acetyl-CoA"}
{"X":23927,"RHEA_ID":31595,"compounds":"(Z)-2-methylureidoacrylate + H2O = (Z)-2-methylaminoacrylate + carbamate + H(+)"}
{"X":23928,"RHEA_ID":21040,"DIRECTION":"UN","MASTER_ID":21040,"ec":"1.2.7.4","compounds":"CO + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2 + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":23929,"RHEA_ID":21041,"compounds":"CO + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => CO2 + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":23930,"RHEA_ID":21042,"compounds":"CO2 + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => CO + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":23931,"RHEA_ID":31600,"DIRECTION":"LR","MASTER_ID":31599,"ecocyc":"RXN-12886","metacyc":"RXN-12886","compounds":"FMNH2 + NADH + O2 + thymine => (Z)-2-methylureidoacrylate + FMN + H(+) + H2O + NAD(+)"}
{"X":23932,"RHEA_ID":21045,"DIRECTION":"LR","MASTER_ID":21044,"metacyc":"2.1.1.143-RXN","compounds":"24-methylidenelophenol + S-adenosyl-L-methionine => (Z)-24-ethylidenelophenol + H(+) + S-adenosyl-L-homocysteine"}
{"X":23933,"RHEA_ID":21046,"compounds":"(Z)-24-ethylidenelophenol + H(+) + S-adenosyl-L-homocysteine => 24-methylidenelophenol + S-adenosyl-L-methionine"}
{"X":23934,"RHEA_ID":31603,"compounds":"(Z)-3-ureidoacrylate + H2O = (Z)-3-aminoacrylate + carbamate + H(+)"}
{"X":23935,"RHEA_ID":31604,"DIRECTION":"LR","MASTER_ID":31603,"ecocyc":"RXN0-6460","metacyc":"RXN0-6460","compounds":"(Z)-3-ureidoacrylate + H2O => (Z)-3-aminoacrylate + carbamate + H(+)"}
{"X":23936,"RHEA_ID":21049,"DIRECTION":"LR","MASTER_ID":21048,"metacyc":"RXN-8940","compounds":"ATP + isopropylamine + L-glutamate => ADP + gamma-glutamyl-isopropylamide + H(+) + phosphate"}
{"X":23937,"RHEA_ID":21050,"compounds":"ADP + gamma-glutamyl-isopropylamide + H(+) + phosphate => ATP + isopropylamine + L-glutamate"}
{"X":23938,"RHEA_ID":21051,"compounds":"ATP + isopropylamine + L-glutamate <=> ADP + gamma-glutamyl-isopropylamide + H(+) + phosphate"}
{"X":23939,"RHEA_ID":31608,"compounds":"rhodopin => all-trans-lycopene + H2O"}
{"X":23940,"RHEA_ID":21053,"DIRECTION":"LR","MASTER_ID":21052,"metacyc":"1.1.1.269-RXN","compounds":"(2S)-2-hydroxypropyl-coenzyme M + NAD(+) => 2-oxopropyl-coenzyme M + H(+) + NADH"}
{"X":23941,"RHEA_ID":21054,"compounds":"2-oxopropyl-coenzyme M + H(+) + NADH => (2S)-2-hydroxypropyl-coenzyme M + NAD(+)"}
{"X":23942,"RHEA_ID":31611,"DIRECTION":"UN","MASTER_ID":31611,"ec":"4.2.1.131","compounds":"1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene = H2O + rhodopin"}
{"X":23943,"RHEA_ID":31612,"compounds":"1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene => H2O + rhodopin"}
{"X":23944,"RHEA_ID":21057,"compounds":"lactoyl-CoA => acryloyl-CoA + H2O"}
{"X":23945,"RHEA_ID":21058,"compounds":"acryloyl-CoA + H2O => lactoyl-CoA"}
{"X":23946,"RHEA_ID":31615,"DIRECTION":"UN","MASTER_ID":31615,"ec":"2.1.1.236","compounds":"dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose + 2 S-adenosyl-L-methionine = dTDP-D-ravidosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine"}
{"X":23947,"RHEA_ID":31616,"DIRECTION":"LR","MASTER_ID":31615,"metacyc":"RXN-12773","compounds":"dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose + 2 S-adenosyl-L-methionine => dTDP-D-ravidosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine"}
{"X":23948,"RHEA_ID":21061,"compounds":"3,4-dichloroaniline + malonyl-CoA => CoA + N-(3,4-dichlorophenyl)malonamate"}
{"X":23949,"RHEA_ID":21062,"compounds":"CoA + N-(3,4-dichlorophenyl)malonamate => 3,4-dichloroaniline + malonyl-CoA"}
{"X":23950,"RHEA_ID":31619,"DIRECTION":"UN","MASTER_ID":31619,"ec":"2.6.1.90","compounds":"2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose = dTDP-3-dehydro-6-deoxy-alpha-D-galactose + L-glutamate"}
{"X":23951,"RHEA_ID":31620,"compounds":"2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose => dTDP-3-dehydro-6-deoxy-alpha-D-galactose + L-glutamate"}
{"X":23952,"RHEA_ID":21065,"compounds":"[protein]-disulfide + 2 glutathione => [protein]-dithiol + glutathione disulfide"}
{"X":23953,"RHEA_ID":21066,"compounds":"[protein]-dithiol + glutathione disulfide => [protein]-disulfide + 2 glutathione"}
{"X":23954,"RHEA_ID":31623,"DIRECTION":"UN","MASTER_ID":31623,"ec":"2.1.1.239","compounds":"L-olivosyl-oleandolide + S-adenosyl-L-methionine = H(+) + L-oleandrosyl-oleandolide + S-adenosyl-L-homocysteine"}
{"X":23955,"RHEA_ID":31624,"DIRECTION":"LR","MASTER_ID":31623,"metacyc":"RXN-12802","compounds":"L-olivosyl-oleandolide + S-adenosyl-L-methionine => H(+) + L-oleandrosyl-oleandolide + S-adenosyl-L-homocysteine"}
{"X":23956,"RHEA_ID":21069,"compounds":"A + H2O + nitrite => AH2 + nitrate"}
{"X":23957,"RHEA_ID":21070,"compounds":"AH2 + nitrate => A + H2O + nitrite"}
{"X":23958,"RHEA_ID":31628,"DIRECTION":"LR","MASTER_ID":31627,"metacyc":"RXN-12807","compounds":"10-deoxymethynolide + dTDP-alpha-D-desosamine => 10-deoxymethymycin + dTDP + H(+)"}
{"X":23959,"RHEA_ID":21073,"DIRECTION":"LR","MASTER_ID":21072,"metacyc":"2.7.8.22-RXN","compounds":"1-O-(1Z)-alkenyl-2-acylglycerol + CDP-choline => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)"}
{"X":23960,"RHEA_ID":21074,"compounds":"1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+) => 1-O-(1Z)-alkenyl-2-acylglycerol + CDP-choline"}
{"X":23961,"RHEA_ID":31631,"DIRECTION":"UN","MASTER_ID":31631,"ec":"2.5.1.97","compounds":"2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H2O + phosphoenolpyruvate = phosphate + pseudaminate"}
{"X":23962,"RHEA_ID":21076,"DIRECTION":"UN","MASTER_ID":21076,"ec":"1.14.11.3","compounds":"2'-deoxyuridine + 2-oxoglutarate + O2 = CO2 + succinate + uridine"}
{"X":23963,"RHEA_ID":31633,"compounds":"phosphate + pseudaminate => 2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H2O + phosphoenolpyruvate"}
{"X":23964,"RHEA_ID":21078,"compounds":"CO2 + succinate + uridine => 2'-deoxyuridine + 2-oxoglutarate + O2"}
{"X":23965,"RHEA_ID":31635,"DIRECTION":"UN","MASTER_ID":31635,"ec":"3.2.1.179","compounds":"beta-D-Delta(4)-GlcpA-(1->4)-beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-D-Glcp + H2O = 5-dehydro-4-deoxy-D-glucuronate + beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-D-Glcp"}
{"X":23966,"RHEA_ID":21080,"DIRECTION":"UN","MASTER_ID":21080,"ec":"2.5.1.6","compounds":"ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine"}
{"X":23967,"RHEA_ID":31637,"compounds":"5-dehydro-4-deoxy-D-glucuronate + beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-D-Glcp => beta-D-Delta(4)-GlcpA-(1->4)-beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-D-Glcp + H2O"}
{"X":23968,"RHEA_ID":21081,"DIRECTION":"LR","MASTER_ID":21080,"ecocyc":"S-ADENMETSYN-RXN","macie":"M0009","metacyc":"S-ADENMETSYN-RXN","reactome":"R-HSA-5603114.1","compounds":"ATP + H2O + L-methionine => diphosphate + phosphate + S-adenosyl-L-methionine"}
{"X":23969,"RHEA_ID":21082,"compounds":"diphosphate + phosphate + S-adenosyl-L-methionine => ATP + H2O + L-methionine"}
{"X":23970,"RHEA_ID":31640,"DIRECTION":"LR","MASTER_ID":31639,"metacyc":"RXN-12800","compounds":"mycinamicin III + S-adenosyl-L-methionine => H(+) + mycinamicin IV + S-adenosyl-L-homocysteine"}
{"X":23971,"RHEA_ID":21084,"DIRECTION":"UN","MASTER_ID":21084,"ec":"5.1.3.19","compounds":"chondroitin 4'-sulfate = dermatan 4'-sulfate"}
{"X":23972,"RHEA_ID":21085,"DIRECTION":"LR","MASTER_ID":21084,"metacyc":"CHONDROITIN-GLUCURONATE-5-EPIMERASE-RXN","compounds":"chondroitin 4'-sulfate => dermatan 4'-sulfate"}
{"X":23973,"RHEA_ID":21086,"compounds":"dermatan 4'-sulfate => chondroitin 4'-sulfate"}
{"X":23974,"RHEA_ID":31645,"compounds":"H(+) + mycinamicin III + S-adenosyl-L-homocysteine => mycinamicin VI + S-adenosyl-L-methionine"}
{"X":23975,"RHEA_ID":21089,"DIRECTION":"LR","MASTER_ID":21088,"metacyc":"RXN-7999","compounds":"2-oxoglutarate + a (2R,3R)-dihydroflavonol + O2 => a flavonol + CO2 + H2O + succinate"}
{"X":23976,"RHEA_ID":21090,"compounds":"a flavonol + CO2 + H2O + succinate => 2-oxoglutarate + a (2R,3R)-dihydroflavonol + O2"}
{"X":23977,"RHEA_ID":31648,"DIRECTION":"LR","MASTER_ID":31647,"metacyc":"RXN-12177","compounds":"beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc6S + H2O => 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine 6-sulfate"}
{"X":23978,"RHEA_ID":31649,"compounds":"5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine 6-sulfate => beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc6S + H2O"}
{"X":23979,"RHEA_ID":21093,"DIRECTION":"LR","MASTER_ID":21092,"metacyc":"2.1.1.120-RXN","compounds":"12-hydroxydihydrochelirubine + S-adenosyl-L-methionine => dihydromacarpine + H(+) + S-adenosyl-L-homocysteine"}
{"X":23980,"RHEA_ID":21094,"compounds":"dihydromacarpine + H(+) + S-adenosyl-L-homocysteine => 12-hydroxydihydrochelirubine + S-adenosyl-L-methionine"}
{"X":23981,"RHEA_ID":31652,"compounds":"beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc + H2O => 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine"}
{"X":23982,"RHEA_ID":21096,"DIRECTION":"UN","MASTER_ID":21096,"ec":"4.2.1.10","compounds":"3-dehydroquinate = 3-dehydroshikimate + H2O"}
{"X":23983,"RHEA_ID":21097,"DIRECTION":"LR","MASTER_ID":21096,"macie":"M0055","compounds":"3-dehydroquinate => 3-dehydroshikimate + H2O"}
{"X":23984,"RHEA_ID":21097,"DIRECTION":"LR","MASTER_ID":21096,"macie":"M0054","compounds":"3-dehydroquinate => 3-dehydroshikimate + H2O"}
{"X":23985,"RHEA_ID":21098,"compounds":"3-dehydroshikimate + H2O => 3-dehydroquinate"}
{"X":23986,"RHEA_ID":31657,"compounds":"5-dehydro-4-deoxy-2-O-sulfo-D-glucuronate + N-acetyl-beta-D-galactosamine => 4-deoxy-Delta(4)-beta-D-GlcpA2S-(1->3)-beta-D-GalpNAc + H2O"}
{"X":23987,"RHEA_ID":21104,"DIRECTION":"UN","MASTER_ID":21104,"ec":"1.14.99.38","compounds":"AH2 + cholesterol + O2 = 25-hydroxycholesterol + A + H2O"}
{"X":23988,"RHEA_ID":21105,"DIRECTION":"LR","MASTER_ID":21104,"metacyc":"1.14.99.38-RXN","compounds":"AH2 + cholesterol + O2 => 25-hydroxycholesterol + A + H2O"}
{"X":23989,"RHEA_ID":21106,"compounds":"25-hydroxycholesterol + A + H2O => AH2 + cholesterol + O2"}
{"X":23990,"RHEA_ID":31661,"compounds":"5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine => beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GlcpNAc + H2O"}
{"X":23991,"RHEA_ID":21108,"DIRECTION":"UN","MASTER_ID":21108,"ec":"4.1.1.72","compounds":"(S)-3-methyl-2-oxopentanoate + H(+) = 2-methylbutanal + CO2"}
{"X":23992,"RHEA_ID":21109,"DIRECTION":"LR","MASTER_ID":21108,"metacyc":"4.1.1.72-RXN","compounds":"(S)-3-methyl-2-oxopentanoate + H(+) => 2-methylbutanal + CO2"}
{"X":23993,"RHEA_ID":21110,"compounds":"2-methylbutanal + CO2 => (S)-3-methyl-2-oxopentanoate + H(+)"}
{"X":23994,"RHEA_ID":21112,"DIRECTION":"UN","MASTER_ID":21112,"ec":"3.2.1.47","compounds":"globoside Gb3Cer (d18:1(4E)) + H2O = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + D-galactose"}
{"X":23995,"RHEA_ID":21113,"DIRECTION":"LR","MASTER_ID":21112,"metacyc":"3.2.1.47-RXN","compounds":"globoside Gb3Cer (d18:1(4E)) + H2O => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + D-galactose"}
{"X":23996,"RHEA_ID":21114,"compounds":"a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + D-galactose => globoside Gb3Cer (d18:1(4E)) + H2O"}
{"X":23997,"RHEA_ID":21116,"DIRECTION":"UN","MASTER_ID":21116,"ec":"2.4.1.8","compounds":"D-maltose + phosphate = beta-D-glucose 1-phosphate + D-glucose"}
{"X":23998,"RHEA_ID":21117,"compounds":"D-maltose + phosphate => beta-D-glucose 1-phosphate + D-glucose"}
{"X":23999,"RHEA_ID":21118,"compounds":"beta-D-glucose 1-phosphate + D-glucose => D-maltose + phosphate"}
{"X":24000,"RHEA_ID":41658,"DIRECTION":"RL","MASTER_ID":41656,"metacyc":"RXN-9276","compounds":"NADPH + sanguinarine => dihydrosanguinarine + NADP(+)"}
{"X":24001,"RHEA_ID":31675,"DIRECTION":"UN","MASTER_ID":31675,"ec":"1.1.1.317","compounds":"NADP(+) + raucaffrinoline = H(+) + NADPH + perakine"}
{"X":24002,"RHEA_ID":21125,"compounds":"cytidine(72) in tRNA(Thr) + S-adenosyl-L-methionine => 5-methylcytidine(72) in tRNA(Thr) + H(+) + S-adenosyl-L-homocysteine"}
{"X":24003,"RHEA_ID":21126,"compounds":"5-methylcytidine(72) in tRNA(Thr) + H(+) + S-adenosyl-L-homocysteine => cytidine(72) in tRNA(Thr) + S-adenosyl-L-methionine"}
{"X":24004,"RHEA_ID":21127,"compounds":"cytidine(72) in tRNA(Thr) + S-adenosyl-L-methionine <=> 5-methylcytidine(72) in tRNA(Thr) + H(+) + S-adenosyl-L-homocysteine"}
{"X":24005,"RHEA_ID":31679,"DIRECTION":"UN","MASTER_ID":31679,"ec":"1.1.3.42","compounds":"O2 + prosolanapyrone II = H2O2 + prosolanapyrone III"}
{"X":24006,"RHEA_ID":21129,"DIRECTION":"LR","MASTER_ID":21128,"metacyc":"RXN3O-178","compounds":"5alpha-cholesta-8,24-dien-3beta-ol + S-adenosyl-L-methionine => 24-methylene-5alpha-cholest-8-en-3beta-ol + H(+) + S-adenosyl-L-homocysteine"}
{"X":24007,"RHEA_ID":21130,"compounds":"24-methylene-5alpha-cholest-8-en-3beta-ol + H(+) + S-adenosyl-L-homocysteine => 5alpha-cholesta-8,24-dien-3beta-ol + S-adenosyl-L-methionine"}
{"X":24008,"RHEA_ID":41666,"DIRECTION":"RL","MASTER_ID":41664,"metacyc":"RXN-15514","compounds":"chelirubine + NADH => dihydrochelirubine + NAD(+)"}
{"X":24009,"RHEA_ID":21132,"DIRECTION":"UN","MASTER_ID":21132,"ec":"1.17.3.2","compounds":"H2O + O2 + xanthine = H2O2 + urate"}
{"X":24010,"RHEA_ID":21133,"DIRECTION":"LR","MASTER_ID":21132,"metacyc":"XANTHINE-OXIDASE-RXN","reactome":"R-HSA-74258.3","compounds":"H2O + O2 + xanthine => H2O2 + urate"}
{"X":24011,"RHEA_ID":21134,"compounds":"H2O2 + urate => H2O + O2 + xanthine"}
{"X":24012,"RHEA_ID":41670,"DIRECTION":"RL","MASTER_ID":41668,"metacyc":"RXN-15514","compounds":"chelirubine + NADPH => dihydrochelirubine + NADP(+)"}
{"X":24013,"RHEA_ID":31687,"DIRECTION":"UN","MASTER_ID":31687,"ec":"1.13.11.61","compounds":"(9Z,12Z,15Z)-octadecatrienoate + O2 = (9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate"}
{"X":24014,"RHEA_ID":21137,"compounds":"(R)-carnitine + acetyl-CoA => CoA + O-acetyl-(R)-carnitine"}
{"X":24015,"RHEA_ID":21138,"compounds":"CoA + O-acetyl-(R)-carnitine => (R)-carnitine + acetyl-CoA"}
{"X":24016,"RHEA_ID":41674,"compounds":"1-O-hexadecyl-sn-glycero-3-phosphate + ADP + H(+) => 1-O-hexadecyl-sn-glycerol + ATP"}
{"X":24017,"RHEA_ID":31691,"DIRECTION":"UN","MASTER_ID":31691,"ec":"1.13.11.61","compounds":"(9Z,12Z)-octadecadienoate + O2 = (9R,10E,12Z)-9-hydroperoxyoctadeca-10,12-dienoate"}
{"X":24018,"RHEA_ID":21141,"DIRECTION":"LR","MASTER_ID":21140,"ecocyc":"INOSINEKIN-RXN","metacyc":"INOSINEKIN-RXN","compounds":"ATP + inosine => ADP + H(+) + IMP"}
{"X":24019,"RHEA_ID":21142,"compounds":"ADP + H(+) + IMP => ATP + inosine"}
{"X":24020,"RHEA_ID":41678,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + ADP + H(+) => 1-O-hexadecyl-2-acetyl-sn-glycerol + ATP"}
{"X":24021,"RHEA_ID":31695,"DIRECTION":"UN","MASTER_ID":31695,"ec":"1.13.11.62","compounds":"(9Z,12Z)-octadecadienoate + O2 = (8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate"}
{"X":24022,"RHEA_ID":21145,"compounds":"5-methyl-5,6,7,8-tetrahydromethanopterin + H(+) + oxidized coenzyme F420-(gamma-Glu)(n) => 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420-(gamma-Glu)(n)"}
{"X":24023,"RHEA_ID":21146,"compounds":"5,10-methylenetetrahydromethanopterin + reduced coenzyme F420-(gamma-Glu)(n) => 5-methyl-5,6,7,8-tetrahydromethanopterin + H(+) + oxidized coenzyme F420-(gamma-Glu)(n)"}
{"X":24024,"RHEA_ID":41682,"compounds":"a 2-all-trans-polyprenylphenol + CO2 => a 4-hydroxy-3-all-trans-polyprenylbenzoate + H(+)"}
{"X":24025,"RHEA_ID":21148,"DIRECTION":"UN","MASTER_ID":21148,"ec":"2.4.1.156","compounds":"indole-3-acetyl-1D-myo-inositol + UDP-alpha-D-galactose = 5-O-(indol-3-ylacetyl)-myo-inositol D-galactoside + H(+) + UDP"}
{"X":24026,"RHEA_ID":21149,"DIRECTION":"LR","MASTER_ID":21148,"metacyc":"2.4.1.156-RXN","compounds":"indole-3-acetyl-1D-myo-inositol + UDP-alpha-D-galactose => 5-O-(indol-3-ylacetyl)-myo-inositol D-galactoside + H(+) + UDP"}
{"X":24027,"RHEA_ID":21150,"compounds":"5-O-(indol-3-ylacetyl)-myo-inositol D-galactoside + H(+) + UDP => indole-3-acetyl-1D-myo-inositol + UDP-alpha-D-galactose"}
{"X":24028,"RHEA_ID":41686,"compounds":"1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate + choline + H(+) => 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine + H2O"}
{"X":24029,"RHEA_ID":21152,"DIRECTION":"UN","MASTER_ID":21152,"ec":"5.1.1.8","compounds":"trans-4-hydroxy-L-proline = cis-4-hydroxy-D-proline"}
{"X":24030,"RHEA_ID":21153,"DIRECTION":"LR","MASTER_ID":21152,"metacyc":"4-HYDROXYPROLINE-EPIMERASE-RXN","compounds":"trans-4-hydroxy-L-proline => cis-4-hydroxy-D-proline"}
{"X":24031,"RHEA_ID":31705,"compounds":"H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-ol => 2 H(+) + O2 + pentalenene + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":24032,"RHEA_ID":41690,"compounds":"1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + propanoate => 1-O-hexadecyl-2-propanoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":24033,"RHEA_ID":21156,"DIRECTION":"UN","MASTER_ID":21156,"ec":"3.1.3.20","compounds":"(2R)-2-phosphoglycerate + H2O = (R)-glycerate + phosphate"}
{"X":24034,"RHEA_ID":21157,"DIRECTION":"LR","MASTER_ID":21156,"metacyc":"PHOSPHOGLYCERATE-PHOSPHATASE-RXN","compounds":"(2R)-2-phosphoglycerate + H2O => (R)-glycerate + phosphate"}
{"X":24035,"RHEA_ID":31709,"compounds":"2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al => 2 H(+) + O2 + pentalen-13-ol + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":24036,"RHEA_ID":41694,"compounds":"1-O-hexadecyl-sn-glycero-3-phosphocholine + butanoate + H(+) => 1-O-hexadecyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":24037,"RHEA_ID":21160,"DIRECTION":"UN","MASTER_ID":21160,"ec":"2.3.3.8","compounds":"acetyl-CoA + ADP + oxaloacetate + phosphate = ATP + citrate + CoA"}
{"X":24038,"RHEA_ID":21161,"compounds":"acetyl-CoA + ADP + oxaloacetate + phosphate => ATP + citrate + CoA"}
{"X":24039,"RHEA_ID":21162,"DIRECTION":"RL","MASTER_ID":21160,"metacyc":"ATP-CITRATE-PRO-S--LYASE-RXN","reactome":"R-HSA-75848.4","compounds":"ATP + citrate + CoA => acetyl-CoA + ADP + oxaloacetate + phosphate"}
{"X":24040,"RHEA_ID":41698,"compounds":"1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + succinate => 1-O-hexadecyl-2-succinyl-sn-glycero-3-phosphocholine + H2O"}
{"X":24041,"RHEA_ID":21164,"DIRECTION":"UN","MASTER_ID":21164,"ec":"3.1.1.1","compounds":"a carboxylic ester + H2O = a carboxylate + an alcohol + H(+)"}
{"X":24042,"RHEA_ID":21165,"DIRECTION":"LR","MASTER_ID":21164,"ecocyc":"CARBOXYLESTERASE-RXN","metacyc":"CARBOXYLESTERASE-RXN","compounds":"a carboxylic ester + H2O => a carboxylate + an alcohol + H(+)"}
{"X":24043,"RHEA_ID":31717,"compounds":"11alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":24044,"RHEA_ID":21168,"DIRECTION":"UN","MASTER_ID":21168,"ec":"1.14.16.3","compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + anthranilate + O2 = (6R)-L-erythro-6,7-dihydrobiopterin + 3-hydroxyanthranilate + H2O"}
{"X":24045,"RHEA_ID":21169,"DIRECTION":"LR","MASTER_ID":21168,"metacyc":"1.14.16.3-RXN","compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + anthranilate + O2 => (6R)-L-erythro-6,7-dihydrobiopterin + 3-hydroxyanthranilate + H2O"}
{"X":24046,"RHEA_ID":31721,"compounds":"11-oxo-beta-amyrin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 11alpha-hydroxy-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":24047,"RHEA_ID":41706,"compounds":"1-O-hexadecyl-sn-glycero-3-phosphate + acetate + H(+) => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + H2O"}
{"X":24048,"RHEA_ID":21172,"DIRECTION":"UN","MASTER_ID":21172,"ec":"1.1.1.264","compounds":"L-idonate + NAD(+) = 5-dehydro-D-gluconate + H(+) + NADH"}
{"X":24049,"RHEA_ID":21172,"DIRECTION":"UN","MASTER_ID":21172,"ec":"1.1.1.366","compounds":"L-idonate + NAD(+) = 5-dehydro-D-gluconate + H(+) + NADH"}
{"X":24050,"RHEA_ID":31725,"compounds":"(2R,3S)-2,4',7-trihydroxyisoflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":24051,"RHEA_ID":21173,"DIRECTION":"LR","MASTER_ID":21172,"ecocyc":"1.1.1.264-RXN","metacyc":"1.1.1.264-RXN","compounds":"L-idonate + NAD(+) => 5-dehydro-D-gluconate + H(+) + NADH"}
{"X":24052,"RHEA_ID":21174,"compounds":"5-dehydro-D-gluconate + H(+) + NADH => L-idonate + NAD(+)"}
{"X":24053,"RHEA_ID":31728,"DIRECTION":"LR","MASTER_ID":31727,"metacyc":"RXN-12764","compounds":"FADH2 + O2 + styrene => (2S)-2-phenyloxirane + FAD + H(+) + H2O"}
{"X":24054,"RHEA_ID":21176,"DIRECTION":"UN","MASTER_ID":21176,"ec":"1.1.1.264","compounds":"L-idonate + NADP(+) = 5-dehydro-D-gluconate + H(+) + NADPH"}
{"X":24055,"RHEA_ID":21177,"DIRECTION":"LR","MASTER_ID":21176,"ecocyc":"1.1.1.264-RXN","metacyc":"1.1.1.264-RXN","compounds":"L-idonate + NADP(+) => 5-dehydro-D-gluconate + H(+) + NADPH"}
{"X":24056,"RHEA_ID":21177,"DIRECTION":"LR","MASTER_ID":21176,"ecocyc":"1.1.1.264-RXN","metacyc":"L-IDONATE-2-DEHYDROGENASE-RXN","compounds":"L-idonate + NADP(+) => 5-dehydro-D-gluconate + H(+) + NADPH"}
{"X":24057,"RHEA_ID":21178,"compounds":"5-dehydro-D-gluconate + H(+) + NADPH => L-idonate + NADP(+)"}
{"X":24058,"RHEA_ID":41717,"compounds":"a 2-acyl-sn-glycero-3-phospho-L-serine + H2O => a 2-acyl-sn-glycerol 3-phosphate + H(+) + L-serine"}
{"X":24059,"RHEA_ID":21180,"DIRECTION":"UN","MASTER_ID":21180,"ec":"2.3.1.72","compounds":"1-O-(indol-3-ylacetyl)-beta-D-glucose + myo-inositol = D-glucose + indole-3-acetyl-1D-myo-inositol"}
{"X":24060,"RHEA_ID":21181,"DIRECTION":"LR","MASTER_ID":21180,"metacyc":"2.3.1.72-RXN","compounds":"1-O-(indol-3-ylacetyl)-beta-D-glucose + myo-inositol => D-glucose + indole-3-acetyl-1D-myo-inositol"}
{"X":24061,"RHEA_ID":21182,"compounds":"D-glucose + indole-3-acetyl-1D-myo-inositol => 1-O-(indol-3-ylacetyl)-beta-D-glucose + myo-inositol"}
{"X":24062,"RHEA_ID":41721,"compounds":"a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":24063,"RHEA_ID":21184,"DIRECTION":"UN","MASTER_ID":21184,"ec":"2.4.1.83","compounds":"dolichyl phosphate + GDP-alpha-D-mannose = dolichyl beta-D-mannosyl phosphate + GDP"}
{"X":24064,"RHEA_ID":21185,"DIRECTION":"LR","MASTER_ID":21184,"metacyc":"2.4.1.83-RXN","compounds":"dolichyl phosphate + GDP-alpha-D-mannose => dolichyl beta-D-mannosyl phosphate + GDP"}
{"X":24065,"RHEA_ID":21186,"compounds":"dolichyl beta-D-mannosyl phosphate + GDP => dolichyl phosphate + GDP-alpha-D-mannose"}
{"X":24066,"RHEA_ID":31741,"compounds":"a 4'-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine => a 4'-hydroxyisoflavone + S-adenosyl-L-methionine"}
{"X":24067,"RHEA_ID":21188,"DIRECTION":"UN","MASTER_ID":21188,"ec":"6.3.1.5","compounds":"ATP + deamido-NAD(+) + NH4(+) = AMP + diphosphate + H(+) + NAD(+)"}
{"X":24068,"RHEA_ID":21189,"DIRECTION":"LR","MASTER_ID":21188,"ecocyc":"NAD-SYNTH-NH3-RXN","macie":"M0200","metacyc":"NAD-SYNTH-NH3-RXN","compounds":"ATP + deamido-NAD(+) + NH4(+) => AMP + diphosphate + H(+) + NAD(+)"}
{"X":24069,"RHEA_ID":21190,"compounds":"AMP + diphosphate + H(+) + NAD(+) => ATP + deamido-NAD(+) + NH4(+)"}
{"X":24070,"RHEA_ID":31745,"compounds":"a 4'-methoxyflavanone + H(+) + S-adenosyl-L-homocysteine => a 4'-hydroxyflavanone + S-adenosyl-L-methionine"}
{"X":24071,"RHEA_ID":21192,"compounds":"D-galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine + H2O = D-galactosyl-N-acetyl-beta-D-galactosamine + L-serine"}
{"X":24072,"RHEA_ID":21193,"compounds":"D-galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine + H2O => D-galactosyl-N-acetyl-beta-D-galactosamine + L-serine"}
{"X":24073,"RHEA_ID":21194,"compounds":"D-galactosyl-N-acetyl-beta-D-galactosamine + L-serine => D-galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine + H2O"}
{"X":24074,"RHEA_ID":31749,"compounds":"3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH => 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde + H2O + NADP(+)"}
{"X":24075,"RHEA_ID":31750,"compounds":"3-oxo-5,6-dehydrosuberyl-CoA semialdehyde + H2O + NADP(+) <=> 3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH"}
{"X":24076,"RHEA_ID":21197,"compounds":"5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine => L-methionine + tetrahydropteroyltri-L-glutamate"}
{"X":24077,"RHEA_ID":21198,"compounds":"L-methionine + tetrahydropteroyltri-L-glutamate => 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine"}
{"X":24078,"RHEA_ID":31753,"compounds":"7(1)-hydroxychlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => chlorophyllide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":24079,"RHEA_ID":21200,"DIRECTION":"UN","MASTER_ID":21200,"ec":"2.6.1.36","compounds":"2-oxoglutarate + L-lysine = (S)-2-amino-6-oxohexanoate + L-glutamate"}
{"X":24080,"RHEA_ID":21201,"compounds":"2-oxoglutarate + L-lysine => (S)-2-amino-6-oxohexanoate + L-glutamate"}
{"X":24081,"RHEA_ID":21202,"compounds":"(S)-2-amino-6-oxohexanoate + L-glutamate => 2-oxoglutarate + L-lysine"}
{"X":24082,"RHEA_ID":31757,"compounds":"3-oxo-5,6-dehydrosuberyl-CoA semialdehyde => 2-oxepin-2(3H)-ylideneacetyl-CoA + H2O"}
{"X":24083,"RHEA_ID":31758,"compounds":"2-oxepin-2(3H)-ylideneacetyl-CoA + H2O <=> 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde"}
{"X":24084,"RHEA_ID":21205,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + a sterol => a 1-acyl-sn-glycero-3-phosphocholine + a sterol ester"}
{"X":24085,"RHEA_ID":21206,"compounds":"a 1-acyl-sn-glycero-3-phosphocholine + a sterol ester => a 1,2-diacyl-sn-glycero-3-phosphocholine + a sterol"}
{"X":24086,"RHEA_ID":41745,"compounds":"3'-phosphoadenylyl sulfate + a 1-O-alkyl-2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol => a 1-O-alkyl-2-acyl-3-(beta-D-3-sulfogalactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+)"}
{"X":24087,"RHEA_ID":21209,"DIRECTION":"LR","MASTER_ID":21208,"ecocyc":"RXN0-5114","metacyc":"PSERPHOSPHA-RXN","reactome":"R-HSA-977324.2","compounds":"H2O + O-phospho-L-serine => L-serine + phosphate"}
{"X":24088,"RHEA_ID":21209,"DIRECTION":"LR","MASTER_ID":21208,"ecocyc":"RXN0-5114","metacyc":"RXN0-5114","reactome":"R-HSA-977324.2","compounds":"H2O + O-phospho-L-serine => L-serine + phosphate"}
{"X":24089,"RHEA_ID":21210,"compounds":"L-serine + phosphate => H2O + O-phospho-L-serine"}
{"X":24090,"RHEA_ID":31766,"DIRECTION":"BI","MASTER_ID":31763,"metacyc":"R15-RXN","compounds":"a 2-oxocarboxylate + L-methionine <=> 4-methylsulfanyl-2-oxobutanoate + an L-alpha-amino acid"}
{"X":24091,"RHEA_ID":21212,"compounds":"H2O + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein] = 4-hydroxy-2-oxobutanal + L-lysyl-[protein] + phosphate"}
{"X":24092,"RHEA_ID":21213,"compounds":"H2O + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein] => 4-hydroxy-2-oxobutanal + L-lysyl-[protein] + phosphate"}
{"X":24093,"RHEA_ID":21214,"compounds":"4-hydroxy-2-oxobutanal + L-lysyl-[protein] + phosphate => H2O + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein]"}
{"X":24094,"RHEA_ID":41753,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H(+)"}
{"X":24095,"RHEA_ID":21216,"DIRECTION":"UN","MASTER_ID":21216,"ec":"2.7.1.18","compounds":"ATP + D-ribose 5-phosphate = ADP + alpha-D-ribose 1,5-bisphosphate + H(+)"}
{"X":24096,"RHEA_ID":21217,"DIRECTION":"LR","MASTER_ID":21216,"metacyc":"PHOSPHORIBOKINASE-RXN","compounds":"ATP + D-ribose 5-phosphate => ADP + alpha-D-ribose 1,5-bisphosphate + H(+)"}
{"X":24097,"RHEA_ID":21218,"compounds":"ADP + alpha-D-ribose 1,5-bisphosphate + H(+) => ATP + D-ribose 5-phosphate"}
{"X":24098,"RHEA_ID":41757,"compounds":"1-O-methyl-(9Z,12Z)-octadecadienoate + O2 => 1-O-methyl-(13S)-hydroperoxy-(9Z,11E)-octadecadienoate"}
{"X":24099,"RHEA_ID":21220,"DIRECTION":"UN","MASTER_ID":21220,"ec":"1.13.11.29","compounds":"L-dopa + O2 = 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)"}
{"X":24100,"RHEA_ID":21221,"DIRECTION":"LR","MASTER_ID":21220,"metacyc":"RXN-8460","compounds":"L-dopa + O2 => 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)"}
{"X":24101,"RHEA_ID":21222,"compounds":"4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+) => L-dopa + O2"}
{"X":24102,"RHEA_ID":41761,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GM3 (d18:1(4E)) => CMP + ganglioside GD3 (d18:1(4E)) + H(+)"}
{"X":24103,"RHEA_ID":21224,"DIRECTION":"UN","MASTER_ID":21224,"ec":"2.7.8.10","metacyc":"2.7.8.10-RXN","compounds":"CDP-choline + sphing-4-enine = CMP + H(+) + sphing-4-enine-phosphocholine"}
{"X":24104,"RHEA_ID":21225,"compounds":"CDP-choline + sphing-4-enine => CMP + H(+) + sphing-4-enine-phosphocholine"}
{"X":24105,"RHEA_ID":21226,"compounds":"CMP + H(+) + sphing-4-enine-phosphocholine => CDP-choline + sphing-4-enine"}
{"X":24106,"RHEA_ID":21228,"DIRECTION":"UN","MASTER_ID":21228,"ec":"5.1.3.21","compounds":"alpha-maltose = beta-maltose"}
{"X":24107,"RHEA_ID":21229,"compounds":"alpha-maltose => beta-maltose"}
{"X":24108,"RHEA_ID":21230,"compounds":"beta-maltose => alpha-maltose"}
{"X":24109,"RHEA_ID":41769,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GD1a (18:1(4E)) => CMP + ganglioside GT1a (d18:1(4E)) + H(+)"}
{"X":24110,"RHEA_ID":31787,"DIRECTION":"UN","MASTER_ID":31787,"ec":"3.1.7.9","compounds":"H2O + tuberculosinyl diphosphate = (13R)-edaxadiene + diphosphate"}
{"X":24111,"RHEA_ID":21233,"DIRECTION":"LR","MASTER_ID":21232,"metacyc":"HISTIDINE-AMMONIA-LYASE-RXN","reactome":"R-HSA-70899.4","compounds":"L-histidine => NH4(+) + trans-urocanate"}
{"X":24112,"RHEA_ID":21234,"compounds":"NH4(+) + trans-urocanate => L-histidine"}
{"X":24113,"RHEA_ID":31790,"compounds":"H2O + tuberculosinyl diphosphate <=> (13R)-edaxadiene + diphosphate"}
{"X":24114,"RHEA_ID":31791,"DIRECTION":"UN","MASTER_ID":31791,"ec":"3.1.7.9","compounds":"H2O + tuberculosinyl diphosphate = (13S)-edaxadiene + diphosphate"}
{"X":24115,"RHEA_ID":21237,"DIRECTION":"LR","MASTER_ID":21236,"metacyc":"1.14.13.35-RXN","compounds":"anthranilate + 2 H(+) + NADPH + O2 => 2,3-dihydroxybenzoate + NADP(+) + NH4(+)"}
{"X":24116,"RHEA_ID":21238,"compounds":"2,3-dihydroxybenzoate + NADP(+) + NH4(+) => anthranilate + 2 H(+) + NADPH + O2"}
{"X":24117,"RHEA_ID":41777,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E)/18:0) => CMP + ganglioside GM2 (d18:1(4E)/18:0) + H(+)"}
{"X":24118,"RHEA_ID":31795,"DIRECTION":"UN","MASTER_ID":31795,"ec":"4.2.1.138","compounds":"(+)-beta-caryophyllene + H2O = (+)-caryolan-1-ol"}
{"X":24119,"RHEA_ID":21240,"DIRECTION":"UN","MASTER_ID":21240,"ec":"2.5.1.59","compounds":"geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein]"}
{"X":24120,"RHEA_ID":21241,"compounds":"geranylgeranyl diphosphate + L-cysteinyl-[protein] => diphosphate + S-geranylgeranyl-L-cysteinyl-[protein]"}
{"X":24121,"RHEA_ID":21242,"compounds":"diphosphate + S-geranylgeranyl-L-cysteinyl-[protein] => geranylgeranyl diphosphate + L-cysteinyl-[protein]"}
{"X":24122,"RHEA_ID":31799,"DIRECTION":"UN","MASTER_ID":31799,"ec":"3.5.99.2","compounds":"4-amino-5-aminomethyl-2-methylpyrimidine + H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + NH4(+)"}
{"X":24123,"RHEA_ID":21244,"DIRECTION":"UN","MASTER_ID":21244,"ec":"2.1.1.70","compounds":"an 8-hydroxyfurocoumarin + S-adenosyl-L-methionine = an 8-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine"}
{"X":24124,"RHEA_ID":21245,"DIRECTION":"LR","MASTER_ID":21244,"metacyc":"2.1.1.70-RXN","compounds":"an 8-hydroxyfurocoumarin + S-adenosyl-L-methionine => an 8-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine"}
{"X":24125,"RHEA_ID":21246,"compounds":"an 8-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine => an 8-hydroxyfurocoumarin + S-adenosyl-L-methionine"}
{"X":24126,"RHEA_ID":41786,"compounds":"CMP + ganglioside GM1 (d18:1(4E)/18:0) + H(+) => asialo-GM1a ganglioside (d18:1(4E)/18:0) + CMP-N-acetyl-beta-neuraminate"}
{"X":24127,"RHEA_ID":21248,"DIRECTION":"UN","MASTER_ID":21248,"ec":"2.7.7.48","compounds":"a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)"}
{"X":24128,"RHEA_ID":21248,"DIRECTION":"UN","MASTER_ID":21248,"ec":"2.7.7.6","compounds":"a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)"}
{"X":24129,"RHEA_ID":21249,"compounds":"a ribonucleoside 5'-triphosphate + RNA(n) => diphosphate + RNA(n+1)"}
{"X":24130,"RHEA_ID":31807,"DIRECTION":"UN","MASTER_ID":31807,"ec":"4.2.3.87","compounds":"(2E,6E)-farnesyl diphosphate = alpha-guaiene + diphosphate"}
{"X":24131,"RHEA_ID":21252,"DIRECTION":"UN","MASTER_ID":21252,"ec":"1.1.99.2","compounds":"(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2"}
{"X":24132,"RHEA_ID":31811,"DIRECTION":"UN","MASTER_ID":31811,"ec":"4.2.3.88","compounds":"(2E,6E)-farnesyl diphosphate = diphosphate + viridiflorene"}
{"X":24133,"RHEA_ID":21254,"compounds":"2-oxoglutarate + AH2 => (S)-2-hydroxyglutarate + A"}
{"X":24134,"RHEA_ID":31813,"compounds":"diphosphate + viridiflorene => (2E,6E)-farnesyl diphosphate"}
{"X":24135,"RHEA_ID":21256,"DIRECTION":"UN","MASTER_ID":21256,"ec":"2.5.1.19","compounds":"3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate"}
{"X":24136,"RHEA_ID":31815,"DIRECTION":"UN","MASTER_ID":31815,"ec":"4.2.3.89","compounds":"(2E,6E)-farnesyl diphosphate = (+)-beta-caryophyllene + diphosphate"}
{"X":24137,"RHEA_ID":21258,"compounds":"5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate => 3-phosphoshikimate + phosphoenolpyruvate"}
{"X":24138,"RHEA_ID":31817,"compounds":"(+)-beta-caryophyllene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":24139,"RHEA_ID":21260,"DIRECTION":"UN","MASTER_ID":21260,"ec":"1.8.4.14","compounds":"[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (R)-S-oxide"}
{"X":24140,"RHEA_ID":31819,"DIRECTION":"UN","MASTER_ID":31819,"ec":"4.2.3.90","compounds":"(2E,6E)-farnesyl diphosphate = 5-epi-alpha-selinene + diphosphate"}
{"X":24141,"RHEA_ID":21262,"DIRECTION":"RL","MASTER_ID":21260,"ecocyc":"1.8.4.14-RXN","metacyc":"1.8.4.14-RXN","compounds":"[thioredoxin]-dithiol + L-methionine (R)-S-oxide => [thioredoxin]-disulfide + H2O + L-methionine"}
{"X":24142,"RHEA_ID":31821,"compounds":"5-epi-alpha-selinene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":24143,"RHEA_ID":21264,"DIRECTION":"UN","MASTER_ID":21264,"ec":"1.1.99.14","compounds":"A + glycolate = AH2 + glyoxylate"}
{"X":24144,"RHEA_ID":21265,"DIRECTION":"LR","MASTER_ID":21264,"ecocyc":"GLYCOLATEDEHYDRO-RXN","metacyc":"GLYCOLATEDEHYDRO-RXN","compounds":"A + glycolate => AH2 + glyoxylate"}
{"X":24145,"RHEA_ID":31824,"DIRECTION":"LR","MASTER_ID":31823,"metacyc":"RXN-12829","compounds":"(2E,6E)-farnesyl diphosphate + H2O => cubebol + diphosphate"}
{"X":24146,"RHEA_ID":21268,"DIRECTION":"UN","MASTER_ID":21268,"ec":"1.5.1.31","metacyc":"1.5.1.31-RXN","compounds":"(R)-canadine + 2 NADP(+) = berberine + H(+) + 2 NADPH"}
{"X":24147,"RHEA_ID":21269,"compounds":"(R)-canadine + 2 NADP(+) => berberine + H(+) + 2 NADPH"}
{"X":24148,"RHEA_ID":31828,"DIRECTION":"LR","MASTER_ID":31827,"metacyc":"RXN-8588","compounds":"(2E,6E)-farnesyl diphosphate => (+)-gamma-cadinene + diphosphate"}
{"X":24149,"RHEA_ID":31829,"compounds":"(+)-gamma-cadinene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":24150,"RHEA_ID":21272,"DIRECTION":"UN","MASTER_ID":21272,"ec":"6.3.1.8","compounds":"ATP + glutathione + spermidine = ADP + glutathionylspermidine + H(+) + phosphate"}
{"X":24151,"RHEA_ID":21272,"DIRECTION":"UN","MASTER_ID":21272,"ec":"6.3.1.9","compounds":"ATP + glutathione + spermidine = ADP + glutathionylspermidine + H(+) + phosphate"}
{"X":24152,"RHEA_ID":21273,"DIRECTION":"LR","MASTER_ID":21272,"ecocyc":"GSPSYN-RXN","compounds":"ATP + glutathione + spermidine => ADP + glutathionylspermidine + H(+) + phosphate"}
{"X":24153,"RHEA_ID":21274,"compounds":"ADP + glutathionylspermidine + H(+) + phosphate => ATP + glutathione + spermidine"}
{"X":24154,"RHEA_ID":41817,"compounds":"ganglioside GD3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => ganglioside GD2 (d18:1(4E)) + H(+) + UDP"}
{"X":24155,"RHEA_ID":21276,"DIRECTION":"UN","MASTER_ID":21276,"ec":"1.1.1.287","compounds":"D-arabinitol + NADP(+) = D-xylulose + H(+) + NADPH"}
{"X":24156,"RHEA_ID":31836,"DIRECTION":"LR","MASTER_ID":31835,"metacyc":"RXN-12839","compounds":"dTDP-4-dehydro-6-deoxy-alpha-D-glucose => dTDP-3-dehydro-6-deoxy-alpha-D-galactose"}
{"X":24157,"RHEA_ID":21278,"compounds":"D-xylulose + H(+) + NADPH => D-arabinitol + NADP(+)"}
{"X":24158,"RHEA_ID":41821,"compounds":"butanoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxohexanoyl-[ACP] + CO2 + holo-[ACP]"}
{"X":24159,"RHEA_ID":21280,"DIRECTION":"UN","MASTER_ID":21280,"ec":"1.1.3.23","compounds":"H2O + 2 O2 + thiamine = H(+) + 2 H2O2 + thiamine acetate"}
{"X":24160,"RHEA_ID":31840,"DIRECTION":"LR","MASTER_ID":31839,"metacyc":"RXN-12840","compounds":"dTDP-4-dehydro-6-deoxy-alpha-D-glucose => dTDP-3-dehydro-6-deoxy-alpha-D-glucose"}
{"X":24161,"RHEA_ID":21282,"compounds":"H(+) + 2 H2O2 + thiamine acetate => H2O + 2 O2 + thiamine"}
{"X":24162,"RHEA_ID":41825,"compounds":"3-oxohexanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxyhexanoyl-[ACP] + NADP(+)"}
{"X":24163,"RHEA_ID":21284,"DIRECTION":"UN","MASTER_ID":21284,"ec":"1.1.1.105","compounds":"all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH"}
{"X":24164,"RHEA_ID":31844,"compounds":"2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA => 2-oxepin-2(3H)-ylideneacetyl-CoA"}
{"X":24165,"RHEA_ID":21285,"DIRECTION":"LR","MASTER_ID":21284,"reactome":"R-HSA-5362518.1","compounds":"all-trans-retinol + NAD(+) => all-trans-retinal + H(+) + NADH"}
{"X":24166,"RHEA_ID":21286,"compounds":"all-trans-retinal + H(+) + NADH => all-trans-retinol + NAD(+)"}
{"X":24167,"RHEA_ID":31847,"DIRECTION":"UN","MASTER_ID":31847,"ec":"5.4.99.46","compounds":"(S)-2,3-epoxysqualene = shionone"}
{"X":24168,"RHEA_ID":31848,"compounds":"(S)-2,3-epoxysqualene => shionone"}
{"X":24169,"RHEA_ID":21289,"compounds":"D-glucose + sn-glycerol 3-phosphate => D-glucose 6-phosphate + glycerol"}
{"X":24170,"RHEA_ID":21290,"compounds":"D-glucose 6-phosphate + glycerol => D-glucose + sn-glycerol 3-phosphate"}
{"X":24171,"RHEA_ID":31851,"DIRECTION":"UN","MASTER_ID":31851,"ec":"5.4.99.47","compounds":"(S)-2,3-epoxysqualene = parkeol"}
{"X":24172,"RHEA_ID":21292,"DIRECTION":"UN","MASTER_ID":21292,"ec":"2.7.1.153","compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)"}
{"X":24173,"RHEA_ID":21293,"DIRECTION":"LR","MASTER_ID":21292,"metacyc":"2.7.1.153-RXN","compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)"}
{"X":24174,"RHEA_ID":21294,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP"}
{"X":24175,"RHEA_ID":31855,"DIRECTION":"UN","MASTER_ID":31855,"ec":"5.4.99.48","compounds":"(S)-2,3-epoxysqualene = achilleol B"}
{"X":24176,"RHEA_ID":31856,"compounds":"(S)-2,3-epoxysqualene => achilleol B"}
{"X":24177,"RHEA_ID":21297,"DIRECTION":"LR","MASTER_ID":21296,"metacyc":"GALACTODEHYDROG-RXN","compounds":"D-galactose + NAD(+) => D-galactono-1,4-lactone + H(+) + NADH"}
{"X":24178,"RHEA_ID":21298,"compounds":"D-galactono-1,4-lactone + H(+) + NADH => D-galactose + NAD(+)"}
{"X":24179,"RHEA_ID":31859,"DIRECTION":"UN","MASTER_ID":31859,"ec":"5.4.99.49","compounds":"(S)-2,3-epoxysqualene = glutinol"}
{"X":24180,"RHEA_ID":31860,"DIRECTION":"LR","MASTER_ID":31859,"metacyc":"RXN-12099","compounds":"(S)-2,3-epoxysqualene => glutinol"}
{"X":24181,"RHEA_ID":21301,"DIRECTION":"LR","MASTER_ID":21300,"metacyc":"CEREBROSIDE-SULFATASE-RXN","compounds":"H2O + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + sulfate"}
{"X":24182,"RHEA_ID":21302,"compounds":"a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + sulfate => H2O + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine"}
{"X":24183,"RHEA_ID":31864,"compounds":"(S)-2,3-epoxysqualene => friedelin"}
{"X":24184,"RHEA_ID":21305,"DIRECTION":"LR","MASTER_ID":21304,"metacyc":"RXN-5242","compounds":"ent-kaur-16-en-19-ol + O2 + reduced [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":24185,"RHEA_ID":21306,"compounds":"ent-kaur-16-en-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-ol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":24186,"RHEA_ID":31867,"DIRECTION":"UN","MASTER_ID":31867,"ec":"5.4.99.51","compounds":"(S)-2,3-epoxysqualene = baccharis oxide"}
{"X":24187,"RHEA_ID":21308,"DIRECTION":"UN","MASTER_ID":21308,"ec":"5.4.99.8","compounds":"(S)-2,3-epoxysqualene = cycloartenol"}
{"X":24188,"RHEA_ID":21309,"DIRECTION":"LR","MASTER_ID":21308,"metacyc":"CYCLOARTENOL-SYNTHASE-RXN","compounds":"(S)-2,3-epoxysqualene => cycloartenol"}
{"X":24189,"RHEA_ID":21310,"compounds":"cycloartenol => (S)-2,3-epoxysqualene"}
{"X":24190,"RHEA_ID":31871,"DIRECTION":"UN","MASTER_ID":31871,"ec":"5.4.99.52","compounds":"(S)-2,3-epoxysqualene = alpha-seco-amyrin"}
{"X":24191,"RHEA_ID":21312,"DIRECTION":"UN","MASTER_ID":21312,"ec":"4.1.1.62","metacyc":"GENTISATE-DECARBOXYLASE-RXN","compounds":"2,5-dihydroxybenzoate + H(+) = CO2 + hydroquinone"}
{"X":24192,"RHEA_ID":21313,"compounds":"2,5-dihydroxybenzoate + H(+) => CO2 + hydroquinone"}
{"X":24193,"RHEA_ID":21314,"compounds":"CO2 + hydroquinone => 2,5-dihydroxybenzoate + H(+)"}
{"X":24194,"RHEA_ID":31875,"DIRECTION":"UN","MASTER_ID":31875,"ec":"5.4.99.53","compounds":"(S)-2,3-epoxysqualene = marneral"}
{"X":24195,"RHEA_ID":31876,"compounds":"(S)-2,3-epoxysqualene => marneral"}
{"X":24196,"RHEA_ID":21317,"DIRECTION":"LR","MASTER_ID":21316,"metacyc":"PHORBOL-DIESTER-HYDROLASE-RXN","compounds":"H2O + phorbol 12,13-dibutanoate => butanoate + H(+) + phorbol 13-butanoate"}
{"X":24197,"RHEA_ID":21318,"compounds":"butanoate + H(+) + phorbol 13-butanoate => H2O + phorbol 12,13-dibutanoate"}
{"X":24198,"RHEA_ID":31879,"DIRECTION":"UN","MASTER_ID":31879,"ec":"5.4.99.54","compounds":"(S)-2,3-epoxysqualene = beta-seco-amyrin"}
{"X":24199,"RHEA_ID":21320,"DIRECTION":"UN","MASTER_ID":21320,"ec":"1.1.99.21","compounds":"A + D-sorbitol = AH2 + keto-L-sorbose"}
{"X":24200,"RHEA_ID":21321,"DIRECTION":"LR","MASTER_ID":21320,"metacyc":"D-SORBITOL-DEHYDROGENASE-RXN","compounds":"A + D-sorbitol => AH2 + keto-L-sorbose"}
{"X":24201,"RHEA_ID":21322,"compounds":"AH2 + keto-L-sorbose => A + D-sorbitol"}
{"X":24202,"RHEA_ID":31883,"DIRECTION":"UN","MASTER_ID":31883,"ec":"5.4.99.55","compounds":"(S)-2,3-epoxysqualene = delta-amyrin"}
{"X":24203,"RHEA_ID":31884,"compounds":"(S)-2,3-epoxysqualene => delta-amyrin"}
{"X":24204,"RHEA_ID":21325,"compounds":"2 H(+) + reduced [rubredoxin] + superoxide => H2O2 + oxidized [rubredoxin]"}
{"X":24205,"RHEA_ID":21326,"compounds":"H2O2 + oxidized [rubredoxin] => 2 H(+) + reduced [rubredoxin] + superoxide"}
{"X":24206,"RHEA_ID":31888,"DIRECTION":"LR","MASTER_ID":31887,"metacyc":"RXN-12326","compounds":"(S)-2,3-epoxysqualene => tirucalladienol"}
{"X":24207,"RHEA_ID":21329,"compounds":"cholesterol + O2 => cholest-4-en-3-one + H2O2"}
{"X":24208,"RHEA_ID":21330,"compounds":"cholest-4-en-3-one + H2O2 => cholesterol + O2"}
{"X":24209,"RHEA_ID":31891,"DIRECTION":"UN","MASTER_ID":31891,"ec":"1.1.1.320","compounds":"2-hydroxy-1-phenyl-1-propanone + NADP(+) = 1-phenyl-1,2-propanedione + H(+) + NADPH"}
{"X":24210,"RHEA_ID":31892,"compounds":"2-hydroxy-1-phenyl-1-propanone + NADP(+) => 1-phenyl-1,2-propanedione + H(+) + NADPH"}
{"X":24211,"RHEA_ID":21333,"compounds":"acetyl-CoA + D-glucosamine => CoA + H(+) + N-acetyl-D-glucosamine"}
{"X":24212,"RHEA_ID":21334,"compounds":"CoA + H(+) + N-acetyl-D-glucosamine => acetyl-CoA + D-glucosamine"}
{"X":24213,"RHEA_ID":31895,"DIRECTION":"UN","MASTER_ID":31895,"ec":"4.2.3.104","compounds":"(2E,6E)-farnesyl diphosphate = (1E,4E,8E)-alpha-humulene + diphosphate"}
{"X":24214,"RHEA_ID":31896,"DIRECTION":"LR","MASTER_ID":31895,"metacyc":"RXN-8415","compounds":"(2E,6E)-farnesyl diphosphate => (1E,4E,8E)-alpha-humulene + diphosphate"}
{"X":24215,"RHEA_ID":21337,"DIRECTION":"LR","MASTER_ID":21336,"metacyc":"PYRIDOXAL-4-DEHYDROGENASE-RXN","compounds":"NAD(+) + pyridoxal => 4-pyridoxolactone + H(+) + NADH"}
{"X":24216,"RHEA_ID":21338,"compounds":"4-pyridoxolactone + H(+) + NADH => NAD(+) + pyridoxal"}
{"X":24217,"RHEA_ID":31899,"DIRECTION":"UN","MASTER_ID":31899,"ec":"1.14.14.153","compounds":"indole + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + indolin-2-one + oxidized [NADPH--hemoprotein reductase]"}
{"X":24218,"RHEA_ID":31900,"DIRECTION":"LR","MASTER_ID":31899,"metacyc":"RXN-6681","compounds":"indole + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + indolin-2-one + oxidized [NADPH--hemoprotein reductase]"}
{"X":24219,"RHEA_ID":21341,"DIRECTION":"LR","MASTER_ID":21340,"metacyc":"LIGNOSTILBENE-ALPHA-BETA-DIOXYGENASE-RXN","compounds":"1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O2 => 2 vanillin"}
{"X":24220,"RHEA_ID":21342,"compounds":"2 vanillin => 1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O2"}
{"X":24221,"RHEA_ID":31907,"DIRECTION":"UN","MASTER_ID":31907,"ec":"2.1.1.128","compounds":"(S)-norcoclaurine + S-adenosyl-L-methionine = (S)-coclaurine + H(+) + S-adenosyl-L-homocysteine"}
{"X":24222,"RHEA_ID":31908,"DIRECTION":"LR","MASTER_ID":31907,"metacyc":"2.1.1.128-RXN","compounds":"(S)-norcoclaurine + S-adenosyl-L-methionine => (S)-coclaurine + H(+) + S-adenosyl-L-homocysteine"}
{"X":24223,"RHEA_ID":21345,"compounds":"5-hydroxybenzimidazolylcob(I)amide + H(+) + methanol => Co-methyl-Co-5-hydroxybenzimidazolylcob(III)amide + H2O"}
{"X":24224,"RHEA_ID":21346,"compounds":"Co-methyl-Co-5-hydroxybenzimidazolylcob(III)amide + H2O => 5-hydroxybenzimidazolylcob(I)amide + H(+) + methanol"}
{"X":24225,"RHEA_ID":31912,"DIRECTION":"LR","MASTER_ID":31911,"metacyc":"RXN-10053","compounds":"beta-D-fructose 1,6-bisphosphate + methylglyoxal => 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde 3-phosphate"}
{"X":24226,"RHEA_ID":21349,"compounds":"8 H(+) + 10 malonyl-CoA => 10 CO2 + 10 CoA + 2 H2O + tetracenomycin F2"}
{"X":24227,"RHEA_ID":21350,"compounds":"10 CO2 + 10 CoA + 2 H2O + tetracenomycin F2 => 8 H(+) + 10 malonyl-CoA"}
{"X":24228,"RHEA_ID":31915,"DIRECTION":"UN","MASTER_ID":31915,"ec":"2.7.1.175","compounds":"ATP + D-maltose = ADP + alpha-maltose 1-phosphate + H(+)"}
{"X":24229,"RHEA_ID":31916,"compounds":"ATP + D-maltose => ADP + alpha-maltose 1-phosphate + H(+)"}
{"X":24230,"RHEA_ID":21353,"DIRECTION":"LR","MASTER_ID":21352,"metacyc":"1.13.11.25-RXN","compounds":"3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 => (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H(+)"}
{"X":24231,"RHEA_ID":21354,"compounds":"(1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H(+) => 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2"}
{"X":24232,"RHEA_ID":31919,"DIRECTION":"UN","MASTER_ID":31919,"ec":"1.14.14.157","compounds":"indolin-2-one + O2 + reduced [NADPH--hemoprotein reductase] = 3-hydroxyindolin-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":24233,"RHEA_ID":31920,"DIRECTION":"LR","MASTER_ID":31919,"metacyc":"RXN-6682","compounds":"indolin-2-one + O2 + reduced [NADPH--hemoprotein reductase] => 3-hydroxyindolin-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":24234,"RHEA_ID":21357,"compounds":"L-arabinitol + NAD(+) => H(+) + L-ribulose + NADH"}
{"X":24235,"RHEA_ID":21358,"compounds":"H(+) + L-ribulose + NADH => L-arabinitol + NAD(+)"}
{"X":24236,"RHEA_ID":31927,"DIRECTION":"UN","MASTER_ID":31927,"ec":"1.14.14.109","compounds":"3-hydroxyindolin-2-one + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":24237,"RHEA_ID":31928,"DIRECTION":"LR","MASTER_ID":31927,"metacyc":"RXN-6683","compounds":"3-hydroxyindolin-2-one + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":24238,"RHEA_ID":21361,"DIRECTION":"LR","MASTER_ID":21360,"ecocyc":"2.7.7.1-RXN","metacyc":"2.7.7.1-RXN","reactome":"R-HSA-8939959.2","compounds":"ATP + beta-nicotinamide D-ribonucleotide + H(+) => diphosphate + NAD(+)"}
{"X":24239,"RHEA_ID":21362,"compounds":"diphosphate + NAD(+) => ATP + beta-nicotinamide D-ribonucleotide + H(+)"}
{"X":24240,"RHEA_ID":31939,"DIRECTION":"UN","MASTER_ID":31939,"ec":"1.14.14.110","compounds":"2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + O2 + reduced [NADPH--hemoprotein reductase] = DIBOA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":24241,"RHEA_ID":21364,"DIRECTION":"UN","MASTER_ID":21364,"ec":"3.5.1.46","compounds":"H2O + N-(6-aminohexanoyl)-6-aminohexanoate = 2 6-aminohexanoate"}
{"X":24242,"RHEA_ID":21365,"DIRECTION":"LR","MASTER_ID":21364,"metacyc":"RXN-3962","compounds":"H2O + N-(6-aminohexanoyl)-6-aminohexanoate => 2 6-aminohexanoate"}
{"X":24243,"RHEA_ID":21366,"compounds":"2 6-aminohexanoate => H2O + N-(6-aminohexanoyl)-6-aminohexanoate"}
{"X":24244,"RHEA_ID":31943,"compounds":"cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (25S)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":24245,"RHEA_ID":21368,"DIRECTION":"UN","MASTER_ID":21368,"ec":"1.7.3.3","compounds":"H2O + O2 + urate = 5-hydroxyisourate + H2O2"}
{"X":24246,"RHEA_ID":21369,"DIRECTION":"LR","MASTER_ID":21368,"macie":"M0118","metacyc":"URATE-OXIDASE-RXN","compounds":"H2O + O2 + urate => 5-hydroxyisourate + H2O2"}
{"X":24247,"RHEA_ID":21370,"compounds":"5-hydroxyisourate + H2O2 => H2O + O2 + urate"}
{"X":24248,"RHEA_ID":31947,"compounds":"ent-isokaurene + O2 + reduced [NADPH--hemoprotein reductase] = ent-isokauren-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":24249,"RHEA_ID":31948,"DIRECTION":"LR","MASTER_ID":31947,"metacyc":"RXN-12879","compounds":"ent-isokaurene + O2 + reduced [NADPH--hemoprotein reductase] => ent-isokauren-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":24250,"RHEA_ID":21373,"compounds":"H(+) + H2O + urethane => CO2 + ethanol + NH4(+)"}
{"X":24251,"RHEA_ID":21374,"compounds":"CO2 + ethanol + NH4(+) => H(+) + H2O + urethane"}
{"X":24252,"RHEA_ID":21376,"DIRECTION":"UN","MASTER_ID":21376,"ec":"1.13.11.46","compounds":"3-(4-hydroxyphenyl)pyruvate + O2 = (S)-4-hydroxymandelate + CO2"}
{"X":24253,"RHEA_ID":21377,"compounds":"3-(4-hydroxyphenyl)pyruvate + O2 => (S)-4-hydroxymandelate + CO2"}
{"X":24254,"RHEA_ID":21378,"compounds":"(S)-4-hydroxymandelate + CO2 => 3-(4-hydroxyphenyl)pyruvate + O2"}
{"X":24255,"RHEA_ID":31955,"compounds":"9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase] = 9beta-pimara-7,15-dien-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":24256,"RHEA_ID":31956,"DIRECTION":"LR","MASTER_ID":31955,"metacyc":"RXN-12880","compounds":"9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-dien-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":24257,"RHEA_ID":21381,"DIRECTION":"LR","MASTER_ID":21380,"metacyc":"PHYTANATE--COA-LIGASE-RXN","reactome":"R-HSA-389622.1","compounds":"3,7,11,15-tetramethylhexadecanoate + ATP + CoA => AMP + diphosphate + phytanoyl-CoA"}
{"X":24258,"RHEA_ID":21382,"compounds":"AMP + diphosphate + phytanoyl-CoA => 3,7,11,15-tetramethylhexadecanoate + ATP + CoA"}
{"X":24259,"RHEA_ID":31959,"compounds":"9beta-pimara-7,15-dien-19-ol + O2 + reduced [NADPH--hemoprotein reductase] = 9beta-pimara-7,15-dien-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":24260,"RHEA_ID":31960,"DIRECTION":"LR","MASTER_ID":31959,"metacyc":"RXN-12881","compounds":"9beta-pimara-7,15-dien-19-ol + O2 + reduced [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-dien-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":24261,"RHEA_ID":21384,"DIRECTION":"UN","MASTER_ID":21384,"ec":"4.3.1.24","compounds":"L-phenylalanine = NH4(+) + trans-cinnamate"}
{"X":24262,"RHEA_ID":21385,"DIRECTION":"LR","MASTER_ID":21384,"metacyc":"PHENYLALANINE-AMMONIA-LYASE-RXN","compounds":"L-phenylalanine => NH4(+) + trans-cinnamate"}
{"X":24263,"RHEA_ID":21386,"compounds":"NH4(+) + trans-cinnamate => L-phenylalanine"}
{"X":24264,"RHEA_ID":31964,"DIRECTION":"LR","MASTER_ID":31963,"metacyc":"RXN-12882","compounds":"9beta-pimara-7,15-dien-19-al + O2 + reduced [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-dien-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":24265,"RHEA_ID":21388,"DIRECTION":"UN","MASTER_ID":21388,"ec":"3.5.2.11","metacyc":"L-LYSINE-LACTAMASE-RXN","compounds":"H2O + L-2-aminohexano-6-lactam = L-lysine"}
{"X":24266,"RHEA_ID":21389,"compounds":"H2O + L-2-aminohexano-6-lactam => L-lysine"}
{"X":24267,"RHEA_ID":21390,"compounds":"L-lysine => H2O + L-2-aminohexano-6-lactam"}
{"X":24268,"RHEA_ID":21392,"DIRECTION":"UN","MASTER_ID":21392,"ec":"1.2.1.39","compounds":"2-phenylacetaldehyde + H2O + NAD(+) = 2-phenylacetate + 2 H(+) + NADH"}
{"X":24269,"RHEA_ID":21393,"compounds":"2-phenylacetaldehyde + H2O + NAD(+) => 2-phenylacetate + 2 H(+) + NADH"}
{"X":24270,"RHEA_ID":21394,"compounds":"2-phenylacetate + 2 H(+) + NADH => 2-phenylacetaldehyde + H2O + NAD(+)"}
{"X":24271,"RHEA_ID":41939,"compounds":"a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + UDP-alpha-D-galactose <=> a neolactoside IV(3)-beta-[Gal-beta-(1->3)-GlcNAc]-nLc4Cer(d18:1(4E)) + H(+) + UDP"}
{"X":24272,"RHEA_ID":21396,"DIRECTION":"UN","MASTER_ID":21396,"ec":"7.2.4.3","compounds":"(S)-methylmalonyl-CoA + H(+)(out) + Na(+)(in) = CO2 + Na(+)(out) + propanoyl-CoA"}
{"X":24273,"RHEA_ID":21397,"DIRECTION":"LR","MASTER_ID":21396,"macie":"M0070","compounds":"(S)-methylmalonyl-CoA + H(+)(out) + Na(+)(in) => CO2 + Na(+)(out) + propanoyl-CoA"}
{"X":24274,"RHEA_ID":21398,"compounds":"CO2 + Na(+)(out) + propanoyl-CoA => (S)-methylmalonyl-CoA + H(+)(out) + Na(+)(in)"}
{"X":24275,"RHEA_ID":51908,"compounds":"dATP + H2O = dADP + H(+) + phosphate"}
{"X":24276,"RHEA_ID":21400,"DIRECTION":"UN","MASTER_ID":21400,"ec":"1.2.1.52","metacyc":"OXOGLUTARATE-DEHYDROGENASE-NADP%252b-RXN","compounds":"2-oxoglutarate + CoA + NADP(+) = CO2 + NADPH + succinyl-CoA"}
{"X":24277,"RHEA_ID":21401,"compounds":"2-oxoglutarate + CoA + NADP(+) => CO2 + NADPH + succinyl-CoA"}
{"X":24278,"RHEA_ID":21402,"compounds":"CO2 + NADPH + succinyl-CoA => 2-oxoglutarate + CoA + NADP(+)"}
{"X":24279,"RHEA_ID":51912,"DIRECTION":"UN","MASTER_ID":51912,"ec":"6.3.2.17","compounds":"(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate"}
{"X":24280,"RHEA_ID":21404,"DIRECTION":"UN","MASTER_ID":21404,"ec":"1.13.11.49","compounds":"chloride + O2 = chlorite"}
{"X":24281,"RHEA_ID":21405,"compounds":"chloride + O2 => chlorite"}
{"X":24282,"RHEA_ID":21406,"compounds":"chlorite => chloride + O2"}
{"X":24283,"RHEA_ID":31984,"DIRECTION":"LR","MASTER_ID":31983,"metacyc":"RXN-8508","compounds":"abieta-7,13-dien-18-ol + O2 + reduced [NADPH--hemoprotein reductase] => abieta-7,13-dien-18,18-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":24284,"RHEA_ID":21408,"DIRECTION":"UN","MASTER_ID":21408,"ec":"1.4.1.20","compounds":"H2O + L-phenylalanine + NAD(+) = 3-phenylpyruvate + H(+) + NADH + NH4(+)"}
{"X":24285,"RHEA_ID":21409,"compounds":"H2O + L-phenylalanine + NAD(+) => 3-phenylpyruvate + H(+) + NADH + NH4(+)"}
{"X":24286,"RHEA_ID":21410,"compounds":"3-phenylpyruvate + H(+) + NADH + NH4(+) => H2O + L-phenylalanine + NAD(+)"}
{"X":24287,"RHEA_ID":51920,"compounds":"a quinone + AH2 = A + a quinol"}
{"X":24288,"RHEA_ID":21412,"DIRECTION":"UN","MASTER_ID":21412,"ec":"1.1.1.261","compounds":"NAD(+) + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H(+) + NADH"}
{"X":24289,"RHEA_ID":21413,"compounds":"NAD(+) + sn-glycerol 1-phosphate => dihydroxyacetone phosphate + H(+) + NADH"}
{"X":24290,"RHEA_ID":21414,"DIRECTION":"RL","MASTER_ID":21412,"metacyc":"1.1.1.261-RXN","compounds":"dihydroxyacetone phosphate + H(+) + NADH => NAD(+) + sn-glycerol 1-phosphate"}
{"X":24291,"RHEA_ID":41959,"compounds":"2',3'-cyclic CMP + H2O <=> cytidine 2'-phosphate + H(+)"}
{"X":24292,"RHEA_ID":21416,"DIRECTION":"UN","MASTER_ID":21416,"ec":"1.1.1.261","compounds":"NADP(+) + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H(+) + NADPH"}
{"X":24293,"RHEA_ID":21417,"compounds":"NADP(+) + sn-glycerol 1-phosphate => dihydroxyacetone phosphate + H(+) + NADPH"}
{"X":24294,"RHEA_ID":21418,"compounds":"dihydroxyacetone phosphate + H(+) + NADPH => NADP(+) + sn-glycerol 1-phosphate"}
{"X":24295,"RHEA_ID":41963,"compounds":"ganglioside GA2 (d18:1(4E)) + UDP-alpha-D-galactose <=> ganglioside GA1 (d18:1(4E)) + H(+) + UDP"}
{"X":24296,"RHEA_ID":21420,"DIRECTION":"UN","MASTER_ID":21420,"ec":"1.1.1.231","metacyc":"1.1.1.231-RXN","compounds":"NADP(+) + prostaglandin I2 = 15-dehydro-prostaglandin I2 + H(+) + NADPH"}
{"X":24297,"RHEA_ID":21421,"compounds":"NADP(+) + prostaglandin I2 => 15-dehydro-prostaglandin I2 + H(+) + NADPH"}
{"X":24298,"RHEA_ID":21422,"compounds":"15-dehydro-prostaglandin I2 + H(+) + NADPH => NADP(+) + prostaglandin I2"}
{"X":24299,"RHEA_ID":41967,"compounds":"butanoyl-CoA + O2 <=> (2E)-butenoyl-CoA + H2O2"}
{"X":24300,"RHEA_ID":21424,"DIRECTION":"UN","MASTER_ID":21424,"ec":"1.1.1.238","compounds":"3alpha,7alpha,12beta-trihydroxy-5beta-cholanate + NADP(+) = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH"}
{"X":24301,"RHEA_ID":21425,"compounds":"3alpha,7alpha,12beta-trihydroxy-5beta-cholanate + NADP(+) => 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH"}
{"X":24302,"RHEA_ID":21426,"compounds":"3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH => 3alpha,7alpha,12beta-trihydroxy-5beta-cholanate + NADP(+)"}
{"X":24303,"RHEA_ID":32004,"compounds":"(+)-copalyl diphosphate => diphosphate + isopimara-8(14),15-diene"}
{"X":24304,"RHEA_ID":21428,"DIRECTION":"UN","MASTER_ID":21428,"ec":"4.4.1.24","compounds":"(R)-3-sulfolactate = H(+) + pyruvate + sulfite"}
{"X":24305,"RHEA_ID":21429,"DIRECTION":"LR","MASTER_ID":21428,"metacyc":"RXN-11691","compounds":"(R)-3-sulfolactate => H(+) + pyruvate + sulfite"}
{"X":24306,"RHEA_ID":21430,"compounds":"H(+) + pyruvate + sulfite => (R)-3-sulfolactate"}
{"X":24307,"RHEA_ID":32008,"compounds":"9alpha-copalyl diphosphate => diphosphate + isopimara-8(14),15-diene"}
{"X":24308,"RHEA_ID":21432,"DIRECTION":"UN","MASTER_ID":21432,"ec":"1.1.1.37","compounds":"(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate"}
{"X":24309,"RHEA_ID":21432,"DIRECTION":"UN","MASTER_ID":21432,"ec":"1.1.1.299","compounds":"(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate"}
{"X":24310,"RHEA_ID":21433,"DIRECTION":"LR","MASTER_ID":21432,"reactome":"R-HSA-198508.2","compounds":"(S)-malate + NAD(+) => H(+) + NADH + oxaloacetate"}
{"X":24311,"RHEA_ID":21433,"DIRECTION":"LR","MASTER_ID":21432,"reactome":"R-HSA-70979.3","compounds":"(S)-malate + NAD(+) => H(+) + NADH + oxaloacetate"}
{"X":24312,"RHEA_ID":32013,"compounds":"(+)-T-muurolol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}
{"X":24313,"RHEA_ID":41981,"compounds":"3alpha-hydroxy-5alpha-pregnan-20-one + NAD(+) => 5alpha-pregnane-3,20-dione + H(+) + NADH"}
{"X":24314,"RHEA_ID":21436,"DIRECTION":"UN","MASTER_ID":21436,"ec":"2.7.11.20","compounds":"[translation elongation factor 2] + ATP = [translation elongation factor 2]-phosphate + ADP + H(+)"}
{"X":24315,"RHEA_ID":21437,"compounds":"[translation elongation factor 2] + ATP => [translation elongation factor 2]-phosphate + ADP + H(+)"}
{"X":24316,"RHEA_ID":32017,"compounds":"(-)-delta-cadinene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":24317,"RHEA_ID":21439,"DIRECTION":"BI","MASTER_ID":21436,"metacyc":"2.7.11.20-RXN","compounds":"[translation elongation factor 2] + ATP <=> [translation elongation factor 2]-phosphate + ADP + H(+)"}
{"X":24318,"RHEA_ID":21440,"DIRECTION":"UN","MASTER_ID":21440,"ec":"4.1.99.5","compounds":"a long-chain fatty aldehyde + H(+) + 2 NADPH + O2 = a long-chain alkane + formate + H2O + 2 NADP(+)"}
{"X":24319,"RHEA_ID":21441,"DIRECTION":"LR","MASTER_ID":21440,"metacyc":"RXN-13262","compounds":"a long-chain fatty aldehyde + H(+) + 2 NADPH + O2 => a long-chain alkane + formate + H2O + 2 NADP(+)"}
{"X":24320,"RHEA_ID":32021,"compounds":"beta-cubebene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":24321,"RHEA_ID":41989,"compounds":"3beta-hydroxy-5alpha-pregnane-20-one + NAD(+) => 5alpha-pregnane-3,20-dione + H(+) + NADH"}
{"X":24322,"RHEA_ID":21444,"DIRECTION":"UN","MASTER_ID":21444,"ec":"1.3.1.11","metacyc":"COUMARATE-REDUCTASE-RXN","compounds":"3-(2-hydroxyphenyl)propanoate + NAD(+) = H(+) + NADH + trans-2-coumarate"}
{"X":24323,"RHEA_ID":21445,"compounds":"3-(2-hydroxyphenyl)propanoate + NAD(+) => H(+) + NADH + trans-2-coumarate"}
{"X":24324,"RHEA_ID":21446,"compounds":"H(+) + NADH + trans-2-coumarate => 3-(2-hydroxyphenyl)propanoate + NAD(+)"}
{"X":24325,"RHEA_ID":51958,"compounds":"(Z)-2-methylpropanal oxime => (E)-2-methylpropanal oxime"}
{"X":24326,"RHEA_ID":32027,"DIRECTION":"UN","MASTER_ID":32027,"ec":"4.2.3.95","compounds":"(2E,6E)-farnesyl diphosphate = (-)-alpha-cuprenene + diphosphate"}
{"X":24327,"RHEA_ID":21449,"compounds":"16 ATP + 16 H2O + N2 + 8 reduced [2Fe-2S]-[ferredoxin] => 16 ADP + 6 H(+) + H2 + 2 NH4(+) + 8 oxidized [2Fe-2S]-[ferredoxin] + 16 phosphate"}
{"X":24328,"RHEA_ID":21450,"compounds":"16 ADP + 6 H(+) + H2 + 2 NH4(+) + 8 oxidized [2Fe-2S]-[ferredoxin] + 16 phosphate => 16 ATP + 16 H2O + N2 + 8 reduced [2Fe-2S]-[ferredoxin]"}
{"X":24329,"RHEA_ID":41997,"compounds":"globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose => globoside GalGb4Cer (d18:1(4E)) + H(+) + UDP"}
{"X":24330,"RHEA_ID":32031,"DIRECTION":"UN","MASTER_ID":32031,"ec":"4.2.3.94","compounds":"(2E,6E)-farnesyl diphosphate = diphosphate + gamma-curcumene"}
{"X":24331,"RHEA_ID":21453,"DIRECTION":"LR","MASTER_ID":21452,"metacyc":"PEPTIDYLGLYCINE-MONOOXYGENASE-RXN","compounds":"a [peptide]-C-terminal glycine + 2 L-ascorbate + O2 => a [peptide]-C-terminal (2S)-2-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical"}
{"X":24332,"RHEA_ID":21454,"compounds":"a [peptide]-C-terminal (2S)-2-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical => a [peptide]-C-terminal glycine + 2 L-ascorbate + O2"}
{"X":24333,"RHEA_ID":21456,"DIRECTION":"UN","MASTER_ID":21456,"ec":"1.14.19.68","compounds":"(S)-tetrahydrocolumbamine + O2 + reduced [NADPH--hemoprotein reductase] = (S)-canadine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":24334,"RHEA_ID":21457,"DIRECTION":"LR","MASTER_ID":21456,"metacyc":"1.1.3.36-RXN","compounds":"(S)-tetrahydrocolumbamine + O2 + reduced [NADPH--hemoprotein reductase] => (S)-canadine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":24335,"RHEA_ID":21458,"compounds":"(S)-canadine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-tetrahydrocolumbamine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":24336,"RHEA_ID":42005,"compounds":"5alpha-androstane-3alpha,17beta-diol + NAD(+) => 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH"}
{"X":24337,"RHEA_ID":21460,"DIRECTION":"UN","MASTER_ID":21460,"ec":"4.1.2.38","compounds":"benzoin = 2 benzaldehyde"}
{"X":24338,"RHEA_ID":21461,"DIRECTION":"LR","MASTER_ID":21460,"macie":"M0221","compounds":"benzoin => 2 benzaldehyde"}
{"X":24339,"RHEA_ID":21462,"compounds":"2 benzaldehyde => benzoin"}
{"X":24340,"RHEA_ID":42009,"compounds":"5alpha-pregnan-20beta-ol-3-one + NAD(+) => 5alpha-pregnane-3,20-dione + H(+) + NADH"}
{"X":24341,"RHEA_ID":21464,"DIRECTION":"UN","MASTER_ID":21464,"ec":"3.5.5.8","compounds":"2 H(+) + H2O + thiocyanate = carbonyl sulfide + NH4(+)"}
{"X":24342,"RHEA_ID":21465,"DIRECTION":"LR","MASTER_ID":21464,"macie":"M0284","metacyc":"RXN-1761","compounds":"2 H(+) + H2O + thiocyanate => carbonyl sulfide + NH4(+)"}
{"X":24343,"RHEA_ID":21466,"compounds":"carbonyl sulfide + NH4(+) => 2 H(+) + H2O + thiocyanate"}
{"X":24344,"RHEA_ID":32047,"DIRECTION":"UN","MASTER_ID":32047,"ec":"3.6.1.60","compounds":"H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate = adenosine 5'-pentaphosphate + AMP + 2 H(+)"}
{"X":24345,"RHEA_ID":21469,"DIRECTION":"LR","MASTER_ID":21468,"metacyc":"RXN-15063","compounds":"dTDP-alpha-D-mycaminose + tylactone => 5-O-beta-D-mycaminosyltylactone + dTDP + H(+)"}
{"X":24346,"RHEA_ID":21470,"compounds":"5-O-beta-D-mycaminosyltylactone + dTDP + H(+) => dTDP-alpha-D-mycaminose + tylactone"}
{"X":24347,"RHEA_ID":42017,"compounds":"cortisone + NAD(+) => 17alpha-hydroxypregn-4-en-3,11,20-trione-21-al + H(+) + NADH"}
{"X":24348,"RHEA_ID":32051,"DIRECTION":"UN","MASTER_ID":32051,"ec":"3.6.1.60","compounds":"H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate = adenosine 5'-tetraphosphate + AMP + 2 H(+)"}
{"X":24349,"RHEA_ID":21473,"DIRECTION":"LR","MASTER_ID":21472,"metacyc":"CITRATE--COA-LIGASE-RXN","compounds":"ATP + citrate + CoA => (3S)-citryl-CoA + ADP + phosphate"}
{"X":24350,"RHEA_ID":21474,"compounds":"(3S)-citryl-CoA + ADP + phosphate => ATP + citrate + CoA"}
{"X":24351,"RHEA_ID":42021,"compounds":"11-dehydrocorticosterone + NAD(+) => H(+) + NADH + pregn-4-ene-3,11,20,21-tetraone"}
{"X":24352,"RHEA_ID":32059,"DIRECTION":"UN","MASTER_ID":32059,"ec":"3.2.1.208","compounds":"(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + H2O = (R)-glycerate + D-glucose"}
{"X":24353,"RHEA_ID":21477,"compounds":"[(1->3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose => [(1->3)-beta-D-glucosyl](n+1) + H(+) + UDP"}
{"X":24354,"RHEA_ID":21478,"compounds":"[(1->3)-beta-D-glucosyl](n+1) + H(+) + UDP => [(1->3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose"}
{"X":24355,"RHEA_ID":32062,"compounds":"(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + H2O <=> (R)-glycerate + D-glucose"}
{"X":24356,"RHEA_ID":32063,"DIRECTION":"UN","MASTER_ID":32063,"ec":"3.6.1.58","compounds":"8-oxo-dGDP + H2O = 8-oxo-dGMP + H(+) + phosphate"}
{"X":24357,"RHEA_ID":21481,"DIRECTION":"LR","MASTER_ID":21480,"metacyc":"2-FUROYL-COA-DEHYDROGENASE-RXN","compounds":"2-furoyl-CoA + A + H2O => 5-hydroxy-2-furoyl-CoA + AH2 + H(+)"}
{"X":24358,"RHEA_ID":21482,"compounds":"5-hydroxy-2-furoyl-CoA + AH2 + H(+) => 2-furoyl-CoA + A + H2O"}
{"X":24359,"RHEA_ID":32065,"compounds":"8-oxo-dGMP + H(+) + phosphate => 8-oxo-dGDP + H2O"}
{"X":24360,"RHEA_ID":42030,"compounds":"7-oxolithocholate + H(+) + NADH => NAD(+) + ursodeoxycholate"}
{"X":24361,"RHEA_ID":21489,"DIRECTION":"LR","MASTER_ID":21488,"metacyc":"RXN-9156","compounds":"dalnigrein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O => beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalnigrein + H(+)"}
{"X":24362,"RHEA_ID":21490,"compounds":"beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalnigrein + H(+) => dalnigrein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O"}
{"X":24363,"RHEA_ID":21491,"compounds":"dalnigrein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O <=> beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalnigrein + H(+)"}
{"X":24364,"RHEA_ID":42034,"compounds":"2 CO2 + 2 formaldehyde + L-lysyl(36)-[histone H3] + 2 succinate => 2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 O2"}
{"X":24365,"RHEA_ID":21493,"compounds":"2,3-dihydroxybenzoate + H(+) => catechol + CO2"}
{"X":24366,"RHEA_ID":21494,"compounds":"catechol + CO2 => 2,3-dihydroxybenzoate + H(+)"}
{"X":24367,"RHEA_ID":32073,"compounds":"(13E)-labda-7,13-dien-15-yl diphosphate => geranylgeranyl diphosphate"}
{"X":24368,"RHEA_ID":21496,"DIRECTION":"UN","MASTER_ID":21496,"ec":"3.1.7.1","compounds":"dimethylallyl diphosphate + H2O = diphosphate + prenol"}
{"X":24369,"RHEA_ID":21497,"DIRECTION":"LR","MASTER_ID":21496,"metacyc":"PRENYL-PYROPHOSPHATASE-RXN","compounds":"dimethylallyl diphosphate + H2O => diphosphate + prenol"}
{"X":24370,"RHEA_ID":21498,"compounds":"diphosphate + prenol => dimethylallyl diphosphate + H2O"}
{"X":24371,"RHEA_ID":42042,"compounds":"fucosyl ganglioside GM1 (d18:1(4E)) + GDP + H(+) => ganglioside GM1 (d18:1(4E)) + GDP-beta-L-fucose"}
{"X":24372,"RHEA_ID":21501,"DIRECTION":"LR","MASTER_ID":21500,"metacyc":"UDP-GLUCOSE-46-DEHYDRATASE-RXN","compounds":"UDP-alpha-D-glucose => H2O + UDP-4-dehydro-6-deoxy-alpha-D-glucose"}
{"X":24373,"RHEA_ID":21502,"compounds":"H2O + UDP-4-dehydro-6-deoxy-alpha-D-glucose => UDP-alpha-D-glucose"}
{"X":24374,"RHEA_ID":32081,"compounds":"(13E)-labda-7,13-dien-15-ol + diphosphate => (13E)-labda-7,13-dien-15-yl diphosphate + H2O"}
{"X":24375,"RHEA_ID":21504,"DIRECTION":"UN","MASTER_ID":21504,"ec":"2.2.1.4","metacyc":"2.2.1.4-RXN","compounds":"acetoin + aldehydo-D-ribose 5-phosphate = 1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde"}
{"X":24376,"RHEA_ID":21505,"compounds":"acetoin + aldehydo-D-ribose 5-phosphate => 1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde"}
{"X":24377,"RHEA_ID":21506,"compounds":"1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde => acetoin + aldehydo-D-ribose 5-phosphate"}
{"X":24378,"RHEA_ID":32085,"compounds":"CMP-pseudaminate + diphosphate => CTP + pseudaminate"}
{"X":24379,"RHEA_ID":42050,"compounds":"acetoacetyl-CoA + H(+) + NADH => 3-hydroxybutanoyl-CoA + NAD(+)"}
{"X":24380,"RHEA_ID":21509,"DIRECTION":"LR","MASTER_ID":21508,"metacyc":"RETINYL-PALMITATE-ESTERASE-RXN","compounds":"all-trans-retinyl hexadecanoate + H2O => H(+) + hexadecanoate + retinol"}
{"X":24381,"RHEA_ID":21510,"compounds":"H(+) + hexadecanoate + retinol => all-trans-retinyl hexadecanoate + H2O"}
{"X":24382,"RHEA_ID":32089,"compounds":"[4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-(S)-4,6-CH3(COO(-))C-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphate => [4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphoenolpyruvate"}
{"X":24383,"RHEA_ID":32090,"compounds":"[4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphoenolpyruvate <=> [4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-(S)-4,6-CH3(COO(-))C-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphate"}
{"X":24384,"RHEA_ID":21513,"DIRECTION":"LR","MASTER_ID":21512,"metacyc":"RXN-15893","compounds":"3,6-anhydro-L-galactonate => 2-dehydro-3-deoxy-L-galactonate"}
{"X":24385,"RHEA_ID":21514,"compounds":"2-dehydro-3-deoxy-L-galactonate => 3,6-anhydro-L-galactonate"}
{"X":24386,"RHEA_ID":32093,"compounds":"dTDP + erythromycin D + H(+) => 3-O-alpha-L-mycarosylerythronolide B + dTDP-alpha-D-desosamine"}
{"X":24387,"RHEA_ID":42058,"compounds":"13-cis-retinal + H(+) + NADH => 13-cis-retinol + NAD(+)"}
{"X":24388,"RHEA_ID":21517,"compounds":"isopiperitenone => piperitenone"}
{"X":24389,"RHEA_ID":21518,"compounds":"piperitenone => isopiperitenone"}
{"X":24390,"RHEA_ID":32097,"compounds":"CoA + dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactopyranose + H(+) => acetyl-CoA + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose"}
{"X":24391,"RHEA_ID":21520,"DIRECTION":"UN","MASTER_ID":21520,"ec":"1.2.2.1","metacyc":"FORMATE-DEHYDROGENASE-CYTOCHROME-RXN","compounds":"2 [Fe(III)-cytochrome b1] + formate = 2 [Fe(II)-cytochrome b1] + CO2 + H(+)"}
{"X":24392,"RHEA_ID":32099,"DIRECTION":"UN","MASTER_ID":32099,"ec":"2.1.1.241","compounds":"S-adenosyl-L-methionine + TRIBOA beta-D-glucoside = DIMBOA beta-D-glucoside + H(+) + S-adenosyl-L-homocysteine"}
{"X":24393,"RHEA_ID":21522,"compounds":"2 [Fe(II)-cytochrome b1] + CO2 + H(+) => 2 [Fe(III)-cytochrome b1] + formate"}
{"X":24394,"RHEA_ID":21524,"DIRECTION":"UN","MASTER_ID":21524,"ec":"2.3.3.13","compounds":"3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)"}
{"X":24395,"RHEA_ID":32103,"DIRECTION":"UN","MASTER_ID":32103,"ec":"2.1.1.240","compounds":"2 S-adenosyl-L-methionine + trans-resveratrol = 2 H(+) + pterostilbene + 2 S-adenosyl-L-homocysteine"}
{"X":24396,"RHEA_ID":21526,"compounds":"(2S)-2-isopropylmalate + CoA + H(+) => 3-methyl-2-oxobutanoate + acetyl-CoA + H2O"}
{"X":24397,"RHEA_ID":32105,"compounds":"2 H(+) + pterostilbene + 2 S-adenosyl-L-homocysteine => 2 S-adenosyl-L-methionine + trans-resveratrol"}
{"X":24398,"RHEA_ID":21528,"DIRECTION":"UN","MASTER_ID":21528,"ec":"3.6.1.11","compounds":"[phosphate](n) + H2O = [phosphate](n-1) + H(+) + phosphate"}
{"X":24399,"RHEA_ID":21529,"DIRECTION":"LR","MASTER_ID":21528,"ecocyc":"EXOPOLYPHOSPHATASE-RXN","metacyc":"EXOPOLYPHOSPHATASE-RXN","compounds":"[phosphate](n) + H2O => [phosphate](n-1) + H(+) + phosphate"}
{"X":24400,"RHEA_ID":21530,"compounds":"[phosphate](n-1) + H(+) + phosphate => [phosphate](n) + H2O"}
{"X":24401,"RHEA_ID":32109,"compounds":"H(+) + pterostilbene + S-adenosyl-L-homocysteine => 3-methoxy-4',5-dihydroxy-trans-stilbene + S-adenosyl-L-methionine"}
{"X":24402,"RHEA_ID":21532,"DIRECTION":"UN","MASTER_ID":21532,"ec":"6.3.1.9","compounds":"ATP + glutathione + glutathionylspermidine = ADP + H(+) + phosphate + trypanothione"}
{"X":24403,"RHEA_ID":21533,"compounds":"ATP + glutathione + glutathionylspermidine => ADP + H(+) + phosphate + trypanothione"}
{"X":24404,"RHEA_ID":21534,"compounds":"ADP + H(+) + phosphate + trypanothione => ATP + glutathione + glutathionylspermidine"}
{"X":24405,"RHEA_ID":42077,"DIRECTION":"LR","MASTER_ID":42076,"metacyc":"RXN-1082","compounds":"2-hydroxyglutarate + acetyl-CoA => 2-hydroxyglutaryl-CoA + acetate"}
{"X":24406,"RHEA_ID":21536,"DIRECTION":"UN","MASTER_ID":21536,"ec":"4.2.1.18","compounds":"(3S)-hydroxy-3-methylglutaryl-CoA = H2O + trans-3-methylglutaconyl-CoA"}
{"X":24407,"RHEA_ID":21537,"compounds":"(3S)-hydroxy-3-methylglutaryl-CoA => H2O + trans-3-methylglutaconyl-CoA"}
{"X":24408,"RHEA_ID":21538,"DIRECTION":"RL","MASTER_ID":21536,"macie":"M0343","reactome":"R-HSA-70785.3","compounds":"H2O + trans-3-methylglutaconyl-CoA => (3S)-hydroxy-3-methylglutaryl-CoA"}
{"X":24409,"RHEA_ID":42081,"DIRECTION":"LR","MASTER_ID":42080,"reactome":"R-HSA-5362522.1","compounds":"all-trans-retinal + H2O + NAD(+) => all-trans-retinoate + 2 H(+) + NADH"}
{"X":24410,"RHEA_ID":21540,"DIRECTION":"UN","MASTER_ID":21540,"ec":"5.3.1.24","compounds":"N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate"}
{"X":24411,"RHEA_ID":21541,"DIRECTION":"LR","MASTER_ID":21540,"ecocyc":"PRAISOM-RXN","metacyc":"PRAISOM-RXN","compounds":"N-(5-phospho-beta-D-ribosyl)anthranilate => 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate"}
{"X":24412,"RHEA_ID":21542,"compounds":"1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate => N-(5-phospho-beta-D-ribosyl)anthranilate"}
{"X":24413,"RHEA_ID":32121,"compounds":"GDP + H(+) + validoxylamine A 7'-phosphate => GDP-valienol + validamine 7-phosphate"}
{"X":24414,"RHEA_ID":21544,"DIRECTION":"UN","MASTER_ID":21544,"ec":"2.7.4.18","metacyc":"FARNESYL-DIPHOSPHATE-KINASE-RXN","compounds":"(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP"}
{"X":24415,"RHEA_ID":21545,"compounds":"(2E,6E)-farnesyl diphosphate + ATP => (2E,6E)-farnesyl triphosphate + ADP"}
{"X":24416,"RHEA_ID":21546,"compounds":"(2E,6E)-farnesyl triphosphate + ADP => (2E,6E)-farnesyl diphosphate + ATP"}
{"X":24417,"RHEA_ID":42089,"compounds":"all-trans-retinal + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":24418,"RHEA_ID":21548,"compounds":"H2O + N(6)-acetyl-L-lysyl-[alpha-tubulin] = acetate + L-lysyl-[alpha-tubulin]"}
{"X":24419,"RHEA_ID":21549,"compounds":"H2O + N(6)-acetyl-L-lysyl-[alpha-tubulin] => acetate + L-lysyl-[alpha-tubulin]"}
{"X":24420,"RHEA_ID":21550,"compounds":"acetate + L-lysyl-[alpha-tubulin] => H2O + N(6)-acetyl-L-lysyl-[alpha-tubulin]"}
{"X":24421,"RHEA_ID":32129,"compounds":"cis-4-hydroxy-L-proline + CO2 + succinate => 2-oxoglutarate + L-proline + O2"}
{"X":24422,"RHEA_ID":21552,"DIRECTION":"UN","MASTER_ID":21552,"ec":"2.4.99.1","compounds":"a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide"}
{"X":24423,"RHEA_ID":21553,"compounds":"a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide"}
{"X":24424,"RHEA_ID":21554,"compounds":"CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate"}
{"X":24425,"RHEA_ID":32133,"compounds":"butanoyl-CoA + CO2 => (2S)-ethylmalonyl-CoA + H(+)"}
{"X":24426,"RHEA_ID":21556,"DIRECTION":"UN","MASTER_ID":21556,"ec":"2.1.1.60","compounds":"[calmodulin]-L-lysine + S-adenosyl-L-methionine = [calmodulin]-N(6)-methyl-L-lysine + H(+) + S-adenosyl-L-homocysteine"}
{"X":24427,"RHEA_ID":21557,"DIRECTION":"LR","MASTER_ID":21556,"metacyc":"2.1.1.60-RXN","compounds":"[calmodulin]-L-lysine + S-adenosyl-L-methionine => [calmodulin]-N(6)-methyl-L-lysine + H(+) + S-adenosyl-L-homocysteine"}
{"X":24428,"RHEA_ID":21558,"compounds":"[calmodulin]-N(6)-methyl-L-lysine + H(+) + S-adenosyl-L-homocysteine => [calmodulin]-L-lysine + S-adenosyl-L-methionine"}
{"X":24429,"RHEA_ID":42101,"DIRECTION":"LR","MASTER_ID":42100,"metacyc":"RXN-15285","compounds":"ATP + carbamoyl phosphate + H2O + kanamycin A => 6''-O-carbamoylkanamycin A + AMP + diphosphate + H(+) + phosphate"}
{"X":24430,"RHEA_ID":21560,"DIRECTION":"UN","MASTER_ID":21560,"ec":"1.17.4.5","compounds":"3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + oxidized dithiothreitol = 1,4-dithiothreitol + 2,3-epoxyphylloquinone"}
{"X":24431,"RHEA_ID":21561,"compounds":"3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + oxidized dithiothreitol => 1,4-dithiothreitol + 2,3-epoxyphylloquinone"}
{"X":24432,"RHEA_ID":21562,"DIRECTION":"RL","MASTER_ID":21560,"metacyc":"1.1.4.2-RXN","compounds":"1,4-dithiothreitol + 2,3-epoxyphylloquinone => 3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + oxidized dithiothreitol"}
{"X":24433,"RHEA_ID":42105,"compounds":"2-hydroxyethylphosphonate + methylcob(III)alamin + S-adenosyl-L-methionine => (S)-2-hydroxypropylphosphonate + 5'-deoxyadenosine + cob(III)alamin + L-methionine"}
{"X":24434,"RHEA_ID":21564,"DIRECTION":"UN","MASTER_ID":21564,"ec":"2.3.1.16","compounds":"acetyl-CoA + an acyl-CoA = a 3-oxoacyl-CoA + CoA"}
{"X":24435,"RHEA_ID":21565,"compounds":"acetyl-CoA + an acyl-CoA => a 3-oxoacyl-CoA + CoA"}
{"X":24436,"RHEA_ID":21566,"DIRECTION":"RL","MASTER_ID":21564,"ecocyc":"KETOACYLCOATHIOL-RXN","metacyc":"KETOACYLCOATHIOL-RXN","compounds":"a 3-oxoacyl-CoA + CoA => acetyl-CoA + an acyl-CoA"}
{"X":24437,"RHEA_ID":32144,"DIRECTION":"LR","MASTER_ID":32143,"reactome":"R-HSA-375776.1","compounds":"L-arginine(in) => L-arginine(out)"}
{"X":24438,"RHEA_ID":21568,"DIRECTION":"UN","MASTER_ID":21568,"ec":"3.2.1.140","compounds":"beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + H2O = beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + lactose"}
{"X":24439,"RHEA_ID":21569,"DIRECTION":"LR","MASTER_ID":21568,"metacyc":"RXN-8731","compounds":"beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + H2O => beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + lactose"}
{"X":24440,"RHEA_ID":21570,"compounds":"beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + lactose => beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + H2O"}
{"X":24441,"RHEA_ID":42113,"compounds":"(20S)-hydroxypregn-4-en-3-one + NADP(+) => H(+) + NADPH + progesterone"}
{"X":24442,"RHEA_ID":21572,"DIRECTION":"UN","MASTER_ID":21572,"ec":"1.13.11.48","compounds":"3-hydroxy-2-methyl-1H-quinolin-4-one + O2 = CO + H(+) + N-acetylanthranilate"}
{"X":24443,"RHEA_ID":21573,"DIRECTION":"LR","MASTER_ID":21572,"metacyc":"1.13.11.48-RXN","compounds":"3-hydroxy-2-methyl-1H-quinolin-4-one + O2 => CO + H(+) + N-acetylanthranilate"}
{"X":24444,"RHEA_ID":21574,"compounds":"CO + H(+) + N-acetylanthranilate => 3-hydroxy-2-methyl-1H-quinolin-4-one + O2"}
{"X":24445,"RHEA_ID":42117,"compounds":"5alpha-androstane-3alpha,17beta-diol + NADP(+) => 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH"}
{"X":24446,"RHEA_ID":21576,"DIRECTION":"UN","MASTER_ID":21576,"ec":"4.1.1.42","compounds":"carnitine + H(+) = 2-methylcholine + CO2"}
{"X":24447,"RHEA_ID":21577,"compounds":"carnitine + H(+) => 2-methylcholine + CO2"}
{"X":24448,"RHEA_ID":21578,"compounds":"2-methylcholine + CO2 => carnitine + H(+)"}
{"X":24449,"RHEA_ID":32151,"DIRECTION":"UN","MASTER_ID":32151,"ec":"4.2.3.99","compounds":"9alpha-copalyl diphosphate = (12E)-9alpha-labda-8(17),12,14-triene + diphosphate"}
{"X":24450,"RHEA_ID":32152,"compounds":"9alpha-copalyl diphosphate => (12E)-9alpha-labda-8(17),12,14-triene + diphosphate"}
{"X":24451,"RHEA_ID":21581,"DIRECTION":"LR","MASTER_ID":21580,"metacyc":"ACETOLACTATE-DECARBOXYLASE-RXN","compounds":"(2S)-2-acetolactate + H(+) => (R)-acetoin + CO2"}
{"X":24452,"RHEA_ID":21582,"compounds":"(R)-acetoin + CO2 => (2S)-2-acetolactate + H(+)"}
{"X":24453,"RHEA_ID":32156,"DIRECTION":"LR","MASTER_ID":32155,"ecocyc":"RXN0-1342","metacyc":"RXN0-1342","compounds":"7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine => adenine + epoxyqueuosine(34) in tRNA + H(+) + L-methionine"}
{"X":24454,"RHEA_ID":21585,"compounds":"NAD(+) + propane-1,2-diol 1-phosphate => H(+) + hydroxyacetone phosphate + NADH"}
{"X":24455,"RHEA_ID":21586,"compounds":"H(+) + hydroxyacetone phosphate + NADH => NAD(+) + propane-1,2-diol 1-phosphate"}
{"X":24456,"RHEA_ID":32159,"DIRECTION":"UN","MASTER_ID":32159,"ec":"1.17.99.6","compounds":"AH2 + epoxyqueuosine(34) in tRNA = A + H2O + queuosine(34) in tRNA"}
{"X":24457,"RHEA_ID":32160,"DIRECTION":"LR","MASTER_ID":32159,"ecocyc":"RXN-12104","metacyc":"RXN-12104","compounds":"AH2 + epoxyqueuosine(34) in tRNA => A + H2O + queuosine(34) in tRNA"}
{"X":24458,"RHEA_ID":21589,"compounds":"N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate => H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH"}
{"X":24459,"RHEA_ID":21590,"compounds":"H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH => N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate"}
{"X":24460,"RHEA_ID":32163,"DIRECTION":"UN","MASTER_ID":32163,"ec":"6.3.2.38","compounds":"ATP + citrate + N(6)-acetyl-N(6)-hydroxy-L-lysine = AMP + diphosphate + H(+) + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine"}
{"X":24461,"RHEA_ID":32164,"DIRECTION":"LR","MASTER_ID":32163,"metacyc":"RXN-13054","compounds":"ATP + citrate + N(6)-acetyl-N(6)-hydroxy-L-lysine => AMP + diphosphate + H(+) + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine"}
{"X":24462,"RHEA_ID":21593,"compounds":"(2S)-2-[(R)-1-carboxyethylamino]pentanoate + H2O + NAD(+) => H(+) + L-2-aminopentanoate + NADH + pyruvate"}
{"X":24463,"RHEA_ID":21594,"compounds":"H(+) + L-2-aminopentanoate + NADH + pyruvate => (2S)-2-[(R)-1-carboxyethylamino]pentanoate + H2O + NAD(+)"}
{"X":24464,"RHEA_ID":32167,"DIRECTION":"UN","MASTER_ID":32167,"ec":"6.3.2.39","compounds":"ATP + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine + N(6)-acetyl-N(6)-hydroxy-L-lysine = aerobactin + AMP + diphosphate + H(+)"}
{"X":24465,"RHEA_ID":32168,"DIRECTION":"LR","MASTER_ID":32167,"metacyc":"RXN-13056","compounds":"ATP + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine + N(6)-acetyl-N(6)-hydroxy-L-lysine => aerobactin + AMP + diphosphate + H(+)"}
{"X":24466,"RHEA_ID":21597,"DIRECTION":"LR","MASTER_ID":21596,"ecocyc":"RXN0-2201","metacyc":"RXN0-2201","compounds":"L-serine + NADP(+) => 2-aminomalonate semialdehyde + H(+) + NADPH"}
{"X":24467,"RHEA_ID":21598,"compounds":"2-aminomalonate semialdehyde + H(+) + NADPH => L-serine + NADP(+)"}
{"X":24468,"RHEA_ID":32171,"DIRECTION":"UN","MASTER_ID":32171,"ec":"1.14.13.149","compounds":"H(+) + NADPH + O2 + phenylacetyl-CoA = 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP(+)"}
{"X":24469,"RHEA_ID":21600,"DIRECTION":"UN","MASTER_ID":21600,"ec":"2.3.1.144","compounds":"anthranilate + benzoyl-CoA = CoA + N-benzoylanthranilate"}
{"X":24470,"RHEA_ID":21601,"DIRECTION":"LR","MASTER_ID":21600,"metacyc":"ANTHRANILATE-N-BENZOYLTRANSFERASE-RXN","compounds":"anthranilate + benzoyl-CoA => CoA + N-benzoylanthranilate"}
{"X":24471,"RHEA_ID":21602,"compounds":"CoA + N-benzoylanthranilate => anthranilate + benzoyl-CoA"}
{"X":24472,"RHEA_ID":32175,"DIRECTION":"UN","MASTER_ID":32175,"ec":"2.4.1.69","compounds":"a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose = alpha-L-fucosyl-(1->2)- beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + GDP + H(+)"}
{"X":24473,"RHEA_ID":21604,"DIRECTION":"UN","MASTER_ID":21604,"ec":"5.3.99.7","compounds":"styrene oxide = 2-phenylacetaldehyde"}
{"X":24474,"RHEA_ID":21605,"compounds":"styrene oxide => 2-phenylacetaldehyde"}
{"X":24475,"RHEA_ID":21606,"compounds":"2-phenylacetaldehyde => styrene oxide"}
{"X":24476,"RHEA_ID":32179,"compounds":"(S)-2,3-dihydrodipicolinate + NAD(+) = dipicolinate + H(+) + NADH"}
{"X":24477,"RHEA_ID":32180,"DIRECTION":"LR","MASTER_ID":32179,"metacyc":"RXN-5041","compounds":"(S)-2,3-dihydrodipicolinate + NAD(+) => dipicolinate + H(+) + NADH"}
{"X":24478,"RHEA_ID":21609,"DIRECTION":"LR","MASTER_ID":21608,"metacyc":"RXN-3501","compounds":"isoliquiritigenin + S-adenosyl-L-methionine => 2'-O-methylisoliquiritigenin + S-adenosyl-L-homocysteine"}
{"X":24479,"RHEA_ID":21610,"compounds":"2'-O-methylisoliquiritigenin + S-adenosyl-L-homocysteine => isoliquiritigenin + S-adenosyl-L-methionine"}
{"X":24480,"RHEA_ID":32183,"DIRECTION":"UN","MASTER_ID":32183,"ec":"1.1.3.6","compounds":"cholesterol + O2 = cholest-5-en-3-one + H2O2"}
{"X":24481,"RHEA_ID":32184,"DIRECTION":"LR","MASTER_ID":32183,"metacyc":"RXN-12778","compounds":"cholesterol + O2 => cholest-5-en-3-one + H2O2"}
{"X":24482,"RHEA_ID":21612,"DIRECTION":"UN","MASTER_ID":21612,"ec":"4.2.1.140","compounds":"D-gluconate = 2-dehydro-3-deoxy-D-gluconate + H2O"}
{"X":24483,"RHEA_ID":21613,"DIRECTION":"LR","MASTER_ID":21612,"metacyc":"GLUCONATE-DEHYDRATASE-RXN","compounds":"D-gluconate => 2-dehydro-3-deoxy-D-gluconate + H2O"}
{"X":24484,"RHEA_ID":21614,"compounds":"2-dehydro-3-deoxy-D-gluconate + H2O => D-gluconate"}
{"X":24485,"RHEA_ID":32188,"DIRECTION":"LR","MASTER_ID":32187,"metacyc":"RXN-12694","compounds":"cholest-5-en-3-one => cholest-4-en-3-one"}
{"X":24486,"RHEA_ID":21616,"DIRECTION":"UN","MASTER_ID":21616,"ec":"2.4.99.4","compounds":"a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)"}
{"X":24487,"RHEA_ID":21617,"DIRECTION":"LR","MASTER_ID":21616,"metacyc":"2.4.99.3-RXN","compounds":"a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate => an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)"}
{"X":24488,"RHEA_ID":21618,"compounds":"an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+) => a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate"}
{"X":24489,"RHEA_ID":32192,"DIRECTION":"LR","MASTER_ID":32191,"metacyc":"RXN-12878","compounds":"H2O + L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-oxoglutarate + 2 H(+) + NH4(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":24490,"RHEA_ID":21620,"DIRECTION":"UN","MASTER_ID":21620,"ec":"1.5.1.39","compounds":"FMNH2 + NAD(+) = FMN + 2 H(+) + NADH"}
{"X":24491,"RHEA_ID":21620,"DIRECTION":"UN","MASTER_ID":21620,"ec":"1.5.1.42","compounds":"FMNH2 + NAD(+) = FMN + 2 H(+) + NADH"}
{"X":24492,"RHEA_ID":21621,"compounds":"FMNH2 + NAD(+) => FMN + 2 H(+) + NADH"}
{"X":24493,"RHEA_ID":32196,"DIRECTION":"LR","MASTER_ID":32195,"metacyc":"RXN-8509","compounds":"abieta-7,13-dien-18,18-diol => abieta-7,13-dien-18-al + H2O"}
{"X":24494,"RHEA_ID":32197,"compounds":"abieta-7,13-dien-18-al + H2O => abieta-7,13-dien-18,18-diol"}
{"X":24495,"RHEA_ID":21624,"DIRECTION":"UN","MASTER_ID":21624,"ec":"1.5.1.38","compounds":"FMNH2 + NADP(+) = FMN + 2 H(+) + NADPH"}
{"X":24496,"RHEA_ID":21624,"DIRECTION":"UN","MASTER_ID":21624,"ec":"1.5.1.39","compounds":"FMNH2 + NADP(+) = FMN + 2 H(+) + NADPH"}
{"X":24497,"RHEA_ID":32200,"DIRECTION":"LR","MASTER_ID":32199,"metacyc":"RXN-12691","compounds":"androsta-1,4-diene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":24498,"RHEA_ID":21626,"DIRECTION":"RL","MASTER_ID":21624,"ecocyc":"FMNREDUCT-RXN","metacyc":"FMNREDUCT-RXN","compounds":"FMN + 2 H(+) + NADPH => FMNH2 + NADP(+)"}
{"X":24499,"RHEA_ID":21626,"DIRECTION":"RL","MASTER_ID":21624,"ecocyc":"FMNREDUCT-RXN","metacyc":"RXN-12444","compounds":"FMN + 2 H(+) + NADPH => FMNH2 + NADP(+)"}
{"X":24500,"RHEA_ID":21626,"DIRECTION":"RL","MASTER_ID":21624,"ecocyc":"RXN-12444","metacyc":"FMNREDUCT-RXN","compounds":"FMN + 2 H(+) + NADPH => FMNH2 + NADP(+)"}
{"X":24501,"RHEA_ID":21626,"DIRECTION":"RL","MASTER_ID":21624,"ecocyc":"RXN-12444","metacyc":"RXN-12444","compounds":"FMN + 2 H(+) + NADPH => FMNH2 + NADP(+)"}
{"X":24502,"RHEA_ID":32205,"compounds":"(4-hydroxyphenyl)acetaldehyde + methylamine => (R)-synephrine"}
{"X":24503,"RHEA_ID":21628,"DIRECTION":"UN","MASTER_ID":21628,"ec":"1.14.13.54","compounds":"17alpha-hydroxyprogesterone + NADPH + O2 = acetate + androst-4-ene-3,17-dione + H2O + NADP(+)"}
{"X":24504,"RHEA_ID":21629,"DIRECTION":"LR","MASTER_ID":21628,"metacyc":"RXN-7819","compounds":"17alpha-hydroxyprogesterone + NADPH + O2 => acetate + androst-4-ene-3,17-dione + H2O + NADP(+)"}
{"X":24505,"RHEA_ID":32208,"compounds":"(2E,4Z)-2-hydroxyhexa-2,4-dienedioate => (3Z)-2-oxohex-3-enedioate"}
{"X":24506,"RHEA_ID":32209,"compounds":"(3Z)-2-oxohex-3-enedioate => (2E,4Z)-2-hydroxyhexa-2,4-dienedioate"}
{"X":24507,"RHEA_ID":21632,"DIRECTION":"UN","MASTER_ID":21632,"ec":"1.10.3.1","compounds":"2 catechol + O2 = 2 1,2-benzoquinone + 2 H2O"}
{"X":24508,"RHEA_ID":21633,"DIRECTION":"LR","MASTER_ID":21632,"macie":"M0125","metacyc":"CATECHOL-OXIDASE-RXN","compounds":"2 catechol + O2 => 2 1,2-benzoquinone + 2 H2O"}
{"X":24509,"RHEA_ID":32212,"compounds":"(Z)-5-oxohex-2-enedioate => (2E,4Z)-2-hydroxyhexa-2,4-dienedioate"}
{"X":24510,"RHEA_ID":32213,"compounds":"(2E,4Z)-2-hydroxyhexa-2,4-dienedioate => (Z)-5-oxohex-2-enedioate"}
{"X":24511,"RHEA_ID":21636,"DIRECTION":"UN","MASTER_ID":21636,"ec":"2.4.1.126","compounds":"trans-4-coumarate + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-trans-4-coumarate + H(+) + UDP"}
{"X":24512,"RHEA_ID":21637,"DIRECTION":"LR","MASTER_ID":21636,"metacyc":"2.4.1.126-RXN","compounds":"trans-4-coumarate + UDP-alpha-D-glucose => 4-O-(beta-D-glucosyl)-trans-4-coumarate + H(+) + UDP"}
{"X":24513,"RHEA_ID":32216,"DIRECTION":"LR","MASTER_ID":32215,"ecocyc":"RXN-12752","metacyc":"RXN-12752","compounds":"(6R)-NADHX => (6S)-NADHX"}
{"X":24514,"RHEA_ID":32217,"compounds":"(6S)-NADHX => (6R)-NADHX"}
{"X":24515,"RHEA_ID":21640,"DIRECTION":"UN","MASTER_ID":21640,"ec":"1.3.1.13","compounds":"NADP(+) + prephenate = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH"}
{"X":24516,"RHEA_ID":21641,"compounds":"NADP(+) + prephenate => 3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH"}
{"X":24517,"RHEA_ID":32220,"DIRECTION":"LR","MASTER_ID":32219,"metacyc":"RXN1F-150","compounds":"all-trans-lycopene => gamma-carotene"}
{"X":24518,"RHEA_ID":32221,"compounds":"gamma-carotene => all-trans-lycopene"}
{"X":24519,"RHEA_ID":21644,"DIRECTION":"UN","MASTER_ID":21644,"ec":"2.7.1.30","compounds":"ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate"}
{"X":24520,"RHEA_ID":21645,"DIRECTION":"LR","MASTER_ID":21644,"ecocyc":"GLYCEROL-KIN-RXN","reactome":"R-HSA-75887.2","compounds":"ATP + glycerol => ADP + H(+) + sn-glycerol 3-phosphate"}
{"X":24521,"RHEA_ID":21646,"compounds":"ADP + H(+) + sn-glycerol 3-phosphate => ATP + glycerol"}
{"X":24522,"RHEA_ID":32225,"compounds":"AMP + H(+) + NADH + phosphate => (6S)-NADHX + ADP"}
{"X":24523,"RHEA_ID":21648,"DIRECTION":"UN","MASTER_ID":21648,"ec":"4.2.1.51","compounds":"H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O"}
{"X":24524,"RHEA_ID":21649,"DIRECTION":"LR","MASTER_ID":21648,"ecocyc":"PREPHENATEDEHYDRAT-RXN","compounds":"H(+) + prephenate => 3-phenylpyruvate + CO2 + H2O"}
{"X":24525,"RHEA_ID":32228,"DIRECTION":"LR","MASTER_ID":32227,"ecocyc":"RXN-13142","metacyc":"RXN-13142","reactome":"R-HSA-6806966.2","compounds":"(6R)-NADPHX => (6S)-NADPHX"}
{"X":24526,"RHEA_ID":32229,"compounds":"(6S)-NADPHX => (6R)-NADPHX"}
{"X":24527,"RHEA_ID":21652,"DIRECTION":"UN","MASTER_ID":21652,"ec":"1.14.12.13","compounds":"2-chlorobenzoate + H(+) + NADH + O2 = catechol + chloride + CO2 + NAD(+)"}
{"X":24528,"RHEA_ID":21653,"DIRECTION":"LR","MASTER_ID":21652,"metacyc":"2-CHLOROBENZOATE-12-DIOXYGENASE-RXN","compounds":"2-chlorobenzoate + H(+) + NADH + O2 => catechol + chloride + CO2 + NAD(+)"}
{"X":24529,"RHEA_ID":32232,"DIRECTION":"LR","MASTER_ID":32231,"metacyc":"RXN-13139","reactome":"R-HSA-6806967.2","compounds":"(6S)-NADPHX + ATP => ADP + H(+) + NADPH + phosphate"}
{"X":24530,"RHEA_ID":32233,"compounds":"ADP + H(+) + NADPH + phosphate => (6S)-NADPHX + ATP"}
{"X":24531,"RHEA_ID":21656,"DIRECTION":"UN","MASTER_ID":21656,"ec":"5.1.3.10","compounds":"CDP-alpha-D-paratose = CDP-3,6-dideoxy-alpha-D-mannose"}
{"X":24532,"RHEA_ID":21657,"DIRECTION":"LR","MASTER_ID":21656,"metacyc":"RXN-9160","compounds":"CDP-alpha-D-paratose => CDP-3,6-dideoxy-alpha-D-mannose"}
{"X":24533,"RHEA_ID":32236,"DIRECTION":"LR","MASTER_ID":32235,"ecocyc":"RXN-13141","metacyc":"RXN-13141","compounds":"(6S)-NADPHX + ADP => AMP + H(+) + NADPH + phosphate"}
{"X":24534,"RHEA_ID":32237,"compounds":"AMP + H(+) + NADPH + phosphate => (6S)-NADPHX + ADP"}
{"X":24535,"RHEA_ID":21660,"DIRECTION":"UN","MASTER_ID":21660,"ec":"1.2.1.7","compounds":"benzaldehyde + H2O + NADP(+) = benzoate + 2 H(+) + NADPH"}
{"X":24536,"RHEA_ID":21661,"DIRECTION":"LR","MASTER_ID":21660,"metacyc":"BENZALDEHYDE-DEHYDROGENASE-NADP%2b-RXN","compounds":"benzaldehyde + H2O + NADP(+) => benzoate + 2 H(+) + NADPH"}
{"X":24537,"RHEA_ID":21662,"compounds":"benzoate + 2 H(+) + NADPH => benzaldehyde + H2O + NADP(+)"}
{"X":24538,"RHEA_ID":32241,"compounds":"all-trans-beta-carotene => gamma-carotene"}
{"X":24539,"RHEA_ID":21664,"DIRECTION":"UN","MASTER_ID":21664,"ec":"3.1.3.41","compounds":"4-nitrophenyl phosphate + H2O = 4-nitrophenol + H(+) + phosphate"}
{"X":24540,"RHEA_ID":21665,"DIRECTION":"LR","MASTER_ID":21664,"ecocyc":"4-NITROPHENYLPHOSPHATASE-RXN","metacyc":"4-NITROPHENYLPHOSPHATASE-RXN","compounds":"4-nitrophenyl phosphate + H2O => 4-nitrophenol + H(+) + phosphate"}
{"X":24541,"RHEA_ID":32244,"DIRECTION":"LR","MASTER_ID":32243,"metacyc":"RXN-8801","compounds":"alpha-D-ribose 1,5-bisphosphate => D-ribulose 1,5-bisphosphate"}
{"X":24542,"RHEA_ID":32245,"compounds":"D-ribulose 1,5-bisphosphate => alpha-D-ribose 1,5-bisphosphate"}
{"X":24543,"RHEA_ID":21668,"DIRECTION":"UN","MASTER_ID":21668,"ec":"7.6.2.10","compounds":"ATP + H2O + sn-glycerol 3-phosphate(out) = ADP + H(+) + phosphate + sn-glycerol 3-phosphate(in)"}
{"X":24544,"RHEA_ID":21669,"DIRECTION":"LR","MASTER_ID":21668,"ecocyc":"ABC-34-RXN","metacyc":"3.6.3.20-RXN","compounds":"ATP + H2O + sn-glycerol 3-phosphate(out) => ADP + H(+) + phosphate + sn-glycerol 3-phosphate(in)"}
{"X":24545,"RHEA_ID":32248,"compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) => (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADPH"}
{"X":24546,"RHEA_ID":21671,"compounds":"ATP + H2O + sn-glycerol 3-phosphate(out) <=> ADP + H(+) + phosphate + sn-glycerol 3-phosphate(in)"}
{"X":24547,"RHEA_ID":21672,"DIRECTION":"UN","MASTER_ID":21672,"ec":"2.1.1.100","compounds":"[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine"}
{"X":24548,"RHEA_ID":21673,"DIRECTION":"LR","MASTER_ID":21672,"metacyc":"2.1.1.100-RXN","compounds":"[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine => [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine"}
{"X":24549,"RHEA_ID":32252,"compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD(+) => (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADH"}
{"X":24550,"RHEA_ID":32253,"DIRECTION":"RL","MASTER_ID":32251,"metacyc":"RXN-14245","compounds":"(6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADH => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD(+)"}
{"X":24551,"RHEA_ID":21676,"DIRECTION":"UN","MASTER_ID":21676,"ec":"2.5.1.69","metacyc":"2.5.1.69-RXN","compounds":"2 dimethylallyl diphosphate = (R)-lavandulyl diphosphate + diphosphate"}
{"X":24552,"RHEA_ID":21677,"compounds":"2 dimethylallyl diphosphate => (R)-lavandulyl diphosphate + diphosphate"}
{"X":24553,"RHEA_ID":32255,"compounds":"meso-2,6-diaminoheptanedioate + NADP(+) = (S)-2,3,4,5-tetrahydrodipicolinate + 2 H(+) + NADPH + NH4(+)"}
{"X":24554,"RHEA_ID":32256,"compounds":"meso-2,6-diaminoheptanedioate + NADP(+) => (S)-2,3,4,5-tetrahydrodipicolinate + 2 H(+) + NADPH + NH4(+)"}
{"X":24555,"RHEA_ID":21680,"DIRECTION":"UN","MASTER_ID":21680,"ec":"1.1.3.27","compounds":"(2S)-2-hydroxyphytanate + O2 = 2-oxophytanate + H2O2"}
{"X":24556,"RHEA_ID":21681,"DIRECTION":"LR","MASTER_ID":21680,"metacyc":"HYDROXYPHYTANATE-OXIDASE-RXN","compounds":"(2S)-2-hydroxyphytanate + O2 => 2-oxophytanate + H2O2"}
{"X":24557,"RHEA_ID":32259,"DIRECTION":"UN","MASTER_ID":32259,"ec":"2.2.1.11","compounds":"beta-D-fructose 1-phosphate + methylglyoxal = 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde"}
{"X":24558,"RHEA_ID":32260,"compounds":"beta-D-fructose 1-phosphate + methylglyoxal => 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde"}
{"X":24559,"RHEA_ID":21684,"DIRECTION":"UN","MASTER_ID":21684,"ec":"1.5.1.26","compounds":"(R)-beta-alanopine + H2O + NAD(+) = beta-alanine + H(+) + NADH + pyruvate"}
{"X":24560,"RHEA_ID":21685,"compounds":"(R)-beta-alanopine + H2O + NAD(+) => beta-alanine + H(+) + NADH + pyruvate"}
{"X":24561,"RHEA_ID":32263,"DIRECTION":"UN","MASTER_ID":32263,"ec":"2.6.1.96","compounds":"4-aminobutanoate + pyruvate = L-alanine + succinate semialdehyde"}
{"X":24562,"RHEA_ID":32264,"compounds":"4-aminobutanoate + pyruvate => L-alanine + succinate semialdehyde"}
{"X":24563,"RHEA_ID":21688,"DIRECTION":"UN","MASTER_ID":21688,"ec":"1.1.3.30","compounds":"a polyvinyl alcohol + n O2 = an oxidized polyvinyl alcohol + n H2O2"}
{"X":24564,"RHEA_ID":21689,"DIRECTION":"LR","MASTER_ID":21688,"metacyc":"POLYVINYL-ALCOHOL-OXIDASE-RXN","compounds":"a polyvinyl alcohol + n O2 => an oxidized polyvinyl alcohol + n H2O2"}
{"X":24565,"RHEA_ID":32267,"DIRECTION":"UN","MASTER_ID":32267,"ec":"2.6.1.96","compounds":"4-aminobutanoate + glyoxylate = glycine + succinate semialdehyde"}
{"X":24566,"RHEA_ID":21692,"DIRECTION":"UN","MASTER_ID":21692,"ec":"3.6.1.16","compounds":"CDP-glycerol + H2O = CMP + 2 H(+) + sn-glycerol 3-phosphate"}
{"X":24567,"RHEA_ID":21693,"compounds":"CDP-glycerol + H2O => CMP + 2 H(+) + sn-glycerol 3-phosphate"}
{"X":24568,"RHEA_ID":32271,"DIRECTION":"UN","MASTER_ID":32271,"ec":"1.1.1.85","compounds":"(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH"}
{"X":24569,"RHEA_ID":32272,"DIRECTION":"LR","MASTER_ID":32271,"ecocyc":"RXN-13158","metacyc":"RXN-13158","compounds":"(2R,3S)-3-isopropylmalate + NAD(+) => 4-methyl-2-oxopentanoate + CO2 + NADH"}
{"X":24570,"RHEA_ID":21696,"compounds":"N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine"}
{"X":24571,"RHEA_ID":21697,"compounds":"N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine"}
{"X":24572,"RHEA_ID":21698,"compounds":"H(+) + N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-methionine"}
{"X":24573,"RHEA_ID":21699,"compounds":"N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine"}
{"X":24574,"RHEA_ID":21700,"DIRECTION":"UN","MASTER_ID":21700,"ec":"3.1.3.77","compounds":"5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate"}
{"X":24575,"RHEA_ID":21701,"DIRECTION":"LR","MASTER_ID":21700,"metacyc":"3.1.3.77-RXN","reactome":"R-HSA-1237129.1","compounds":"5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O => 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate"}
{"X":24576,"RHEA_ID":32279,"compounds":"allantoate + 2 H(+) + 2 H2O = (S)-ureidoglycolate + CO2 + 2 NH4(+)"}
{"X":24577,"RHEA_ID":32280,"compounds":"allantoate + 2 H(+) + 2 H2O => (S)-ureidoglycolate + CO2 + 2 NH4(+)"}
{"X":24578,"RHEA_ID":21704,"DIRECTION":"UN","MASTER_ID":21704,"ec":"4.1.99.2","compounds":"H2O + L-tyrosine = NH4(+) + phenol + pyruvate"}
{"X":24579,"RHEA_ID":21705,"compounds":"H2O + L-tyrosine => NH4(+) + phenol + pyruvate"}
{"X":24580,"RHEA_ID":32283,"compounds":"3-hydroxyanthranilate + O2 = H(+) + H2O + quinolinate"}
{"X":24581,"RHEA_ID":21708,"DIRECTION":"UN","MASTER_ID":21708,"ec":"3.3.1.1","compounds":"H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine"}
{"X":24582,"RHEA_ID":21709,"DIRECTION":"LR","MASTER_ID":21708,"macie":"M0090","compounds":"H2O + S-adenosyl-L-homocysteine => adenosine + L-homocysteine"}
{"X":24583,"RHEA_ID":32287,"DIRECTION":"UN","MASTER_ID":32287,"ec":"4.2.1.33","compounds":"(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate"}
{"X":24584,"RHEA_ID":32288,"compounds":"(2R,3S)-3-isopropylmalate => (2S)-2-isopropylmalate"}
{"X":24585,"RHEA_ID":21712,"DIRECTION":"UN","MASTER_ID":21712,"ec":"4.1.2.26","compounds":"L-threo-3-phenylserine = benzaldehyde + glycine"}
{"X":24586,"RHEA_ID":21713,"compounds":"L-threo-3-phenylserine => benzaldehyde + glycine"}
{"X":24587,"RHEA_ID":32291,"compounds":"phosphoethanolamine + 3 S-adenosyl-L-methionine = 3 H(+) + phosphocholine + 3 S-adenosyl-L-homocysteine"}
{"X":24588,"RHEA_ID":32292,"compounds":"phosphoethanolamine + 3 S-adenosyl-L-methionine => 3 H(+) + phosphocholine + 3 S-adenosyl-L-homocysteine"}
{"X":24589,"RHEA_ID":21716,"DIRECTION":"UN","MASTER_ID":21716,"ec":"1.14.16.6","compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + (S)-mandelate + O2 = (6R)-L-erythro-6,7-dihydrobiopterin + (S)-4-hydroxymandelate + H2O"}
{"X":24590,"RHEA_ID":21717,"DIRECTION":"LR","MASTER_ID":21716,"metacyc":"MANDELATE-4-MONOOXYGENASE-RXN","compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + (S)-mandelate + O2 => (6R)-L-erythro-6,7-dihydrobiopterin + (S)-4-hydroxymandelate + H2O"}
{"X":24591,"RHEA_ID":32295,"DIRECTION":"UN","MASTER_ID":32295,"ec":"2.5.1.21","compounds":"2 (2E,6E)-farnesyl diphosphate + H(+) + NADPH = 2 diphosphate + NADP(+) + squalene"}
{"X":24592,"RHEA_ID":32296,"DIRECTION":"LR","MASTER_ID":32295,"macie":"M0264","metacyc":"RXN-13162","compounds":"2 (2E,6E)-farnesyl diphosphate + H(+) + NADPH => 2 diphosphate + NADP(+) + squalene"}
{"X":24593,"RHEA_ID":21720,"DIRECTION":"UN","MASTER_ID":21720,"ec":"4.2.1.66","compounds":"formamide = H2O + hydrogen cyanide"}
{"X":24594,"RHEA_ID":21721,"compounds":"formamide => H2O + hydrogen cyanide"}
{"X":24595,"RHEA_ID":21722,"DIRECTION":"RL","MASTER_ID":21720,"metacyc":"CYANIDE-HYDRATASE-RXN","compounds":"H2O + hydrogen cyanide => formamide"}
{"X":24596,"RHEA_ID":21724,"DIRECTION":"UN","MASTER_ID":21724,"ec":"3.5.5.1","compounds":"a nitrile + 2 H2O = a carboxylate + NH4(+)"}
{"X":24597,"RHEA_ID":21725,"DIRECTION":"LR","MASTER_ID":21724,"metacyc":"3.5.5.1-RXN","compounds":"a nitrile + 2 H2O => a carboxylate + NH4(+)"}
{"X":24598,"RHEA_ID":21726,"compounds":"a carboxylate + NH4(+) => a nitrile + 2 H2O"}
{"X":24599,"RHEA_ID":32304,"compounds":"(2R)-homocitrate => (1R,2S)-homoisocitrate"}
{"X":24600,"RHEA_ID":21728,"DIRECTION":"UN","MASTER_ID":21728,"ec":"1.1.1.132","compounds":"GDP-alpha-D-mannose + H2O + 2 NAD(+) = GDP-alpha-D-mannuronate + 3 H(+) + 2 NADH"}
{"X":24601,"RHEA_ID":21729,"DIRECTION":"LR","MASTER_ID":21728,"metacyc":"GDP-MANNOSE-6-DEHYDROGENASE-RXN","compounds":"GDP-alpha-D-mannose + H2O + 2 NAD(+) => GDP-alpha-D-mannuronate + 3 H(+) + 2 NADH"}
{"X":24602,"RHEA_ID":21730,"compounds":"GDP-alpha-D-mannuronate + 3 H(+) + 2 NADH => GDP-alpha-D-mannose + H2O + 2 NAD(+)"}
{"X":24603,"RHEA_ID":42279,"compounds":"2-methylbutanoyl-CoA + H(+) + malonyl-[ACP] <=> 3-oxo-4-methylhexanoyl-[ACP] + CO2 + CoA"}
{"X":24604,"RHEA_ID":21732,"DIRECTION":"UN","MASTER_ID":21732,"ec":"4.1.3.27","compounds":"chorismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate"}
{"X":24605,"RHEA_ID":21733,"DIRECTION":"LR","MASTER_ID":21732,"ecocyc":"ANTHRANSYN-RXN","macie":"M0314","compounds":"chorismate + L-glutamine => anthranilate + H(+) + L-glutamate + pyruvate"}
{"X":24606,"RHEA_ID":21734,"compounds":"anthranilate + H(+) + L-glutamate + pyruvate => chorismate + L-glutamine"}
{"X":24607,"RHEA_ID":32312,"DIRECTION":"LR","MASTER_ID":32311,"metacyc":"RXN-13187","compounds":"L-tyrosine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-4-hydroxyphenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":24608,"RHEA_ID":21736,"DIRECTION":"UN","MASTER_ID":21736,"ec":"5.4.3.3","compounds":"(3S)-3,6-diaminohexanoate = (3S,5S)-3,5-diaminohexanoate"}
{"X":24609,"RHEA_ID":42285,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate"}
{"X":24610,"RHEA_ID":21738,"compounds":"(3S,5S)-3,5-diaminohexanoate => (3S)-3,6-diaminohexanoate"}
{"X":24611,"RHEA_ID":32324,"DIRECTION":"LR","MASTER_ID":32323,"metacyc":"RXN-13190","compounds":"ent-kaur-16-ene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}
{"X":24612,"RHEA_ID":21740,"DIRECTION":"UN","MASTER_ID":21740,"ec":"2.8.1.2","compounds":"3-mercaptopyruvate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + H(+) + hydrogen sulfide + pyruvate"}
{"X":24613,"RHEA_ID":42289,"DIRECTION":"LR","MASTER_ID":42288,"ecocyc":"RXN-11484","metacyc":"RXN-11484","compounds":"6-carboxyhexanoyl-[ACP] + H(+) + L-alanine => 8-amino-7-oxononanoate + CO2 + holo-[ACP]"}
{"X":24614,"RHEA_ID":21742,"compounds":"[thioredoxin]-disulfide + H(+) + hydrogen sulfide + pyruvate => 3-mercaptopyruvate + [thioredoxin]-dithiol"}
{"X":24615,"RHEA_ID":21744,"DIRECTION":"UN","MASTER_ID":21744,"ec":"4.4.1.14","compounds":"S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + H(+) + S-methyl-5'-thioadenosine"}
{"X":24616,"RHEA_ID":21745,"DIRECTION":"LR","MASTER_ID":21744,"metacyc":"4.4.1.14-RXN","compounds":"S-adenosyl-L-methionine => 1-aminocyclopropane-1-carboxylate + H(+) + S-methyl-5'-thioadenosine"}
{"X":24617,"RHEA_ID":21746,"compounds":"1-aminocyclopropane-1-carboxylate + H(+) + S-methyl-5'-thioadenosine => S-adenosyl-L-methionine"}
{"X":24618,"RHEA_ID":32332,"compounds":"(1S,2S,4R)-endo-fenchol + NAD(+) => (1S,4R)-fenchone + H(+) + NADH"}
{"X":24619,"RHEA_ID":21748,"DIRECTION":"UN","MASTER_ID":21748,"ec":"1.1.1.283","compounds":"(S)-lactaldehyde + NADP(+) = H(+) + methylglyoxal + NADPH"}
{"X":24620,"RHEA_ID":42297,"DIRECTION":"LR","MASTER_ID":42296,"ecocyc":"1-ACYLGLYCEROL-3-P-ACYLTRANSFER-RXN","metacyc":"1-ACYLGLYCEROL-3-P-ACYLTRANSFER-RXN","compounds":"a 1-acyl-sn-glycero-3-phosphate + a fatty acyl-[ACP] => a 1,2-diacyl-sn-glycero-3-phosphate + holo-[ACP]"}
{"X":24621,"RHEA_ID":21750,"DIRECTION":"RL","MASTER_ID":21748,"ecocyc":"1.1.1.283-RXN","metacyc":"1.1.1.283-RXN","compounds":"H(+) + methylglyoxal + NADPH => (S)-lactaldehyde + NADP(+)"}
{"X":24622,"RHEA_ID":21752,"DIRECTION":"UN","MASTER_ID":21752,"ec":"5.3.99.8","compounds":"all-trans-violaxanthin = all-trans-capsorubin"}
{"X":24623,"RHEA_ID":42301,"DIRECTION":"LR","MASTER_ID":42300,"ecocyc":"RXN-10462","metacyc":"RXN-10462","compounds":"a fatty acyl-[ACP] + sn-glycerol 3-phosphate => a 1-acyl-sn-glycero-3-phosphate + holo-[ACP]"}
{"X":24624,"RHEA_ID":21754,"compounds":"all-trans-capsorubin => all-trans-violaxanthin"}
{"X":24625,"RHEA_ID":32340,"compounds":"(+)-thujan-3-ol + NADP(+) => (+)-thujan-3-one + H(+) + NADPH"}
{"X":24626,"RHEA_ID":21756,"DIRECTION":"UN","MASTER_ID":21756,"ec":"4.3.3.3","compounds":"deacetylisoipecoside + H2O = dopamine + secologanin"}
{"X":24627,"RHEA_ID":42305,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol-3'-phosphate) + H2O => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate"}
{"X":24628,"RHEA_ID":21758,"compounds":"dopamine + secologanin => deacetylisoipecoside + H2O"}
{"X":24629,"RHEA_ID":32344,"compounds":"(+)-thujan-3-ol + NAD(+) => (+)-thujan-3-one + H(+) + NADH"}
{"X":24630,"RHEA_ID":21760,"DIRECTION":"UN","MASTER_ID":21760,"ec":"5.1.2.3","compounds":"(3S)-hydroxybutanoyl-CoA = (3R)-hydroxybutanoyl-CoA"}
{"X":24631,"RHEA_ID":42309,"compounds":"1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}
{"X":24632,"RHEA_ID":21762,"compounds":"(3R)-hydroxybutanoyl-CoA => (3S)-hydroxybutanoyl-CoA"}
{"X":24633,"RHEA_ID":32348,"DIRECTION":"LR","MASTER_ID":32347,"metacyc":"RXN-13196","compounds":"2 S-adenosyl-L-methionine + tricetin => 3',5'-di-O-methyltricetin + 2 H(+) + 2 S-adenosyl-L-homocysteine"}
{"X":24634,"RHEA_ID":21764,"DIRECTION":"UN","MASTER_ID":21764,"ec":"1.14.14.18","compounds":"heme b + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = biliverdin IXalpha + CO + Fe(2+) + H(+) + 3 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}
{"X":24635,"RHEA_ID":21765,"DIRECTION":"LR","MASTER_ID":21764,"metacyc":"HEME-OXYGENASE-DECYCLIZING-RXN","compounds":"heme b + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => biliverdin IXalpha + CO + Fe(2+) + H(+) + 3 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}
{"X":24636,"RHEA_ID":21766,"compounds":"biliverdin IXalpha + CO + Fe(2+) + H(+) + 3 H2O + 3 oxidized [NADPH--hemoprotein reductase] => heme b + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]"}
{"X":24637,"RHEA_ID":32352,"DIRECTION":"LR","MASTER_ID":32351,"metacyc":"RXN-11585","compounds":"3 S-adenosyl-L-methionine + tricetin => 3',4',5'-O-trimethyltricetin + 3 H(+) + 3 S-adenosyl-L-homocysteine"}
{"X":24638,"RHEA_ID":21768,"DIRECTION":"UN","MASTER_ID":21768,"ec":"1.4.1.17","compounds":"H2O + N-methyl-L-alanine + NADP(+) = H(+) + methylamine + NADPH + pyruvate"}
{"X":24639,"RHEA_ID":21769,"compounds":"H2O + N-methyl-L-alanine + NADP(+) => H(+) + methylamine + NADPH + pyruvate"}
{"X":24640,"RHEA_ID":21770,"compounds":"H(+) + methylamine + NADPH + pyruvate => H2O + N-methyl-L-alanine + NADP(+)"}
{"X":24641,"RHEA_ID":32356,"DIRECTION":"LR","MASTER_ID":32355,"metacyc":"RXN-13411","compounds":"delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + 2 UDP-alpha-D-glucose => 2 H(+) + ternatin C5 + 2 UDP"}
{"X":24642,"RHEA_ID":21772,"DIRECTION":"UN","MASTER_ID":21772,"ec":"3.5.4.36","compounds":"cytidine(6666) in apoB mRNA + H(+) + H2O = NH4(+) + uridine(6666) in apoB mRNA"}
{"X":24643,"RHEA_ID":21773,"compounds":"cytidine(6666) in apoB mRNA + H(+) + H2O => NH4(+) + uridine(6666) in apoB mRNA"}
{"X":24644,"RHEA_ID":32359,"DIRECTION":"UN","MASTER_ID":32359,"ec":"2.7.1.151","compounds":"1D-myo-inositol 1,4,5-trisphosphate + 2 ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+)"}
{"X":24645,"RHEA_ID":21775,"DIRECTION":"BI","MASTER_ID":21772,"metacyc":"RXN-13994","compounds":"cytidine(6666) in apoB mRNA + H(+) + H2O <=> NH4(+) + uridine(6666) in apoB mRNA"}
{"X":24646,"RHEA_ID":21776,"DIRECTION":"UN","MASTER_ID":21776,"ec":"6.2.1.28","compounds":"(25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate + ATP + CoA = (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate"}
{"X":24647,"RHEA_ID":21777,"DIRECTION":"LR","MASTER_ID":21776,"metacyc":"6.2.1.28-RXN","compounds":"(25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate + ATP + CoA => (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate"}
{"X":24648,"RHEA_ID":32363,"DIRECTION":"UN","MASTER_ID":32363,"ec":"1.1.3.8","compounds":"L-gulono-1,4-lactone + O2 = H(+) + H2O2 + L-ascorbate"}
{"X":24649,"RHEA_ID":32364,"DIRECTION":"LR","MASTER_ID":32363,"metacyc":"RXN-13689","compounds":"L-gulono-1,4-lactone + O2 => H(+) + H2O2 + L-ascorbate"}
{"X":24650,"RHEA_ID":21780,"DIRECTION":"UN","MASTER_ID":21780,"ec":"1.3.99.14","metacyc":"CYCLOHEXANONE-DEHYDROGENASE-RXN","compounds":"A + cyclohexanone = AH2 + cyclohex-2-enone"}
{"X":24651,"RHEA_ID":21781,"compounds":"A + cyclohexanone => AH2 + cyclohex-2-enone"}
{"X":24652,"RHEA_ID":21782,"compounds":"AH2 + cyclohex-2-enone => A + cyclohexanone"}
{"X":24653,"RHEA_ID":32368,"compounds":"4 [Fe(III)cytochrome c] + L-galactono-1,4-lactone => 4 [Fe(II)cytochrome c] + 5 H(+) + L-dehydroascorbate"}
{"X":24654,"RHEA_ID":21784,"compounds":"H2O + L-ascorbate + O2 = 2 H(+) + L-threonate + oxalate"}
{"X":24655,"RHEA_ID":21785,"compounds":"H2O + L-ascorbate + O2 => 2 H(+) + L-threonate + oxalate"}
{"X":24656,"RHEA_ID":32371,"DIRECTION":"UN","MASTER_ID":32371,"ec":"1.23.5.1","compounds":"all-trans-violaxanthin + 2 L-ascorbate = all-trans-zeaxanthin + 2 H2O + 2 L-dehydroascorbate"}
{"X":24657,"RHEA_ID":32372,"compounds":"all-trans-violaxanthin + 2 L-ascorbate => all-trans-zeaxanthin + 2 H2O + 2 L-dehydroascorbate"}
{"X":24658,"RHEA_ID":21788,"compounds":"2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + O2 = CO2 + formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + succinate"}
{"X":24659,"RHEA_ID":21789,"DIRECTION":"LR","MASTER_ID":21788,"metacyc":"RXN-20631","compounds":"2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + O2 => CO2 + formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + succinate"}
{"X":24660,"RHEA_ID":32375,"compounds":"limonene-1,2-diol + NAD(+) = 1-hydroxylimonen-2-one + H(+) + NADH"}
{"X":24661,"RHEA_ID":21791,"compounds":"2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + succinate"}
{"X":24662,"RHEA_ID":21792,"DIRECTION":"UN","MASTER_ID":21792,"ec":"1.1.1.80","compounds":"NADP(+) + propan-2-ol = acetone + H(+) + NADPH"}
{"X":24663,"RHEA_ID":21793,"compounds":"NADP(+) + propan-2-ol => acetone + H(+) + NADPH"}
{"X":24664,"RHEA_ID":32379,"DIRECTION":"UN","MASTER_ID":32379,"ec":"1.1.1.297","compounds":"(1R,2R,4S)-limonene-1,2-diol + NAD(+) = (1R,4S)-1-hydroxylimonen-2-one + H(+) + NADH"}
{"X":24665,"RHEA_ID":21796,"DIRECTION":"UN","MASTER_ID":21796,"ec":"1.1.1.133","compounds":"dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH"}
{"X":24666,"RHEA_ID":21797,"compounds":"dTDP-beta-L-rhamnose + NADP(+) => dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH"}
{"X":24667,"RHEA_ID":32383,"DIRECTION":"UN","MASTER_ID":32383,"ec":"1.1.1.297","compounds":"(1S,2S,4R)-limonene-1,2-diol + NAD(+) = (1S,4R)-1-hydroxylimonen-2-one + H(+) + NADH"}
{"X":24668,"RHEA_ID":32384,"compounds":"(1S,2S,4R)-limonene-1,2-diol + NAD(+) => (1S,4R)-1-hydroxylimonen-2-one + H(+) + NADH"}
{"X":24669,"RHEA_ID":21800,"compounds":"all-trans-antheraxanthin + L-ascorbate = all-trans-zeaxanthin + H2O + L-dehydroascorbate"}
{"X":24670,"RHEA_ID":21801,"DIRECTION":"LR","MASTER_ID":21800,"metacyc":"RXN-7985","compounds":"all-trans-antheraxanthin + L-ascorbate => all-trans-zeaxanthin + H2O + L-dehydroascorbate"}
{"X":24671,"RHEA_ID":32387,"DIRECTION":"UN","MASTER_ID":32387,"ec":"1.1.1.296","compounds":"dihydrocarveol + NAD(+) = dihydrocarvone + H(+) + NADH"}
{"X":24672,"RHEA_ID":32388,"compounds":"dihydrocarveol + NAD(+) => dihydrocarvone + H(+) + NADH"}
{"X":24673,"RHEA_ID":21804,"DIRECTION":"UN","MASTER_ID":21804,"ec":"2.7.1.64","compounds":"ATP + myo-inositol = 1D-myo-inositol 3-phosphate + ADP + H(+)"}
{"X":24674,"RHEA_ID":21805,"DIRECTION":"LR","MASTER_ID":21804,"metacyc":"MYO-INOSITOL-1-KINASE-RXN","compounds":"ATP + myo-inositol => 1D-myo-inositol 3-phosphate + ADP + H(+)"}
{"X":24675,"RHEA_ID":42354,"compounds":"(R)-6-hydroxynicotine + AH2 => (R)-nicotine + A + H2O"}
{"X":24676,"RHEA_ID":32391,"DIRECTION":"UN","MASTER_ID":32391,"ec":"1.1.1.296","compounds":"(1R,2R,4R)-dihydrocarveol + NAD(+) = (1R,4R)-dihydrocarvone + H(+) + NADH"}
{"X":24677,"RHEA_ID":21808,"DIRECTION":"UN","MASTER_ID":21808,"ec":"3.5.2.13","metacyc":"25-DIOXOPIPERAZINE-HYDROLASE-RXN","compounds":"2,5-dioxopiperazine + H2O = glycylglycine"}
{"X":24678,"RHEA_ID":21809,"compounds":"2,5-dioxopiperazine + H2O => glycylglycine"}
{"X":24679,"RHEA_ID":21810,"compounds":"glycylglycine => 2,5-dioxopiperazine + H2O"}
{"X":24680,"RHEA_ID":32395,"DIRECTION":"UN","MASTER_ID":32395,"ec":"1.1.1.296","compounds":"(1S,2S,4S)-dihydrocarveol + NAD(+) = (1S,4S)-dihydrocarvone + H(+) + NADH"}
{"X":24681,"RHEA_ID":21812,"DIRECTION":"UN","MASTER_ID":21812,"ec":"1.14.14.23","compounds":"cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":24682,"RHEA_ID":21813,"DIRECTION":"LR","MASTER_ID":21812,"metacyc":"CHOLESTEROL-7-ALPHA-MONOOXYGENASE-RXN","compounds":"cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":24683,"RHEA_ID":32398,"compounds":"(1S,2S,4S)-dihydrocarveol + NAD(+) <=> (1S,4S)-dihydrocarvone + H(+) + NADH"}
{"X":24684,"RHEA_ID":32399,"DIRECTION":"UN","MASTER_ID":32399,"ec":"1.1.1.296","compounds":"(1S,2R,4S)-neodihydrocarveol + NAD(+) = (1S,4S)-dihydrocarvone + H(+) + NADH"}
{"X":24685,"RHEA_ID":21816,"DIRECTION":"UN","MASTER_ID":21816,"ec":"1.4.3.3","compounds":"a D-alpha-amino acid + H2O + O2 = a 2-oxocarboxylate + H2O2 + NH4(+)"}
{"X":24686,"RHEA_ID":21817,"DIRECTION":"LR","MASTER_ID":21816,"metacyc":"D-AMINO-ACID-OXIDASE-RXN","compounds":"a D-alpha-amino acid + H2O + O2 => a 2-oxocarboxylate + H2O2 + NH4(+)"}
{"X":24687,"RHEA_ID":32402,"compounds":"(1S,2R,4S)-neodihydrocarveol + NAD(+) <=> (1S,4S)-dihydrocarvone + H(+) + NADH"}
{"X":24688,"RHEA_ID":21820,"DIRECTION":"UN","MASTER_ID":21820,"ec":"2.1.1.10","compounds":"L-homocysteine + S-adenosyl-L-methionine = H(+) + L-methionine + S-adenosyl-L-homocysteine"}
{"X":24689,"RHEA_ID":21821,"DIRECTION":"LR","MASTER_ID":21820,"ecocyc":"HOMOCYSTEINE-S-METHYLTRANSFERASE-RXN","metacyc":"HOMOCYSTEINE-S-METHYLTRANSFERASE-RXN","compounds":"L-homocysteine + S-adenosyl-L-methionine => H(+) + L-methionine + S-adenosyl-L-homocysteine"}
{"X":24690,"RHEA_ID":32406,"compounds":"(1R,2S,4R)-neodihydrocarveol + NAD(+) <=> (1R,4R)-dihydrocarvone + H(+) + NADH"}
{"X":24691,"RHEA_ID":32407,"DIRECTION":"UN","MASTER_ID":32407,"ec":"1.1.1.296","compounds":"(1R,2S,4S)-neoisodihydrocarveol + NAD(+) = (1R,4S)-isodihydrocarvone + H(+) + NADH"}
{"X":24692,"RHEA_ID":21824,"DIRECTION":"UN","MASTER_ID":21824,"ec":"2.6.1.1","compounds":"2-oxoglutarate + L-aspartate = L-glutamate + oxaloacetate"}
{"X":24693,"RHEA_ID":21825,"DIRECTION":"LR","MASTER_ID":21824,"reactome":"R-HSA-70592.4","compounds":"2-oxoglutarate + L-aspartate => L-glutamate + oxaloacetate"}
{"X":24694,"RHEA_ID":32410,"compounds":"(1R,2S,4S)-neoisodihydrocarveol + NAD(+) <=> (1R,4S)-isodihydrocarvone + H(+) + NADH"}
{"X":24695,"RHEA_ID":21826,"DIRECTION":"RL","MASTER_ID":21824,"reactome":"R-HSA-70581.2","compounds":"L-glutamate + oxaloacetate => 2-oxoglutarate + L-aspartate"}
{"X":24696,"RHEA_ID":21826,"DIRECTION":"RL","MASTER_ID":21824,"reactome":"R-HSA-70613.3","compounds":"L-glutamate + oxaloacetate => 2-oxoglutarate + L-aspartate"}
{"X":24697,"RHEA_ID":32413,"compounds":"(1R,4S)-isodihydrocarvone + H(+) + NADH => (1R,2R,4S)-isodihydrocarveol + NAD(+)"}
{"X":24698,"RHEA_ID":32414,"compounds":"(1R,2R,4S)-isodihydrocarveol + NAD(+) <=> (1R,4S)-isodihydrocarvone + H(+) + NADH"}
{"X":24699,"RHEA_ID":21829,"compounds":"H2O + nitrite + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + nitrate + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":24700,"RHEA_ID":21830,"DIRECTION":"RL","MASTER_ID":21828,"metacyc":"1.7.7.2-RXN","compounds":"2 H(+) + nitrate + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + nitrite + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":24701,"RHEA_ID":32418,"compounds":"(1S,2S,4R)-isodihydrocarveol + NAD(+) <=> (1S,4R)-isodihydrocarvone + H(+) + NADH"}
{"X":24702,"RHEA_ID":21833,"DIRECTION":"LR","MASTER_ID":21832,"metacyc":"2.1.1.83-RXN","compounds":"3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine => 3',5-dihydroxy-3,4',7-trimethoxyflavone + H(+) + S-adenosyl-L-homocysteine"}
{"X":24703,"RHEA_ID":21834,"compounds":"3',5-dihydroxy-3,4',7-trimethoxyflavone + H(+) + S-adenosyl-L-homocysteine => 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine"}
{"X":24704,"RHEA_ID":32421,"compounds":"(1S,4R)-isodihydrocarvone + H(+) + NADH => (1S,2R,4R)-neoisodihydrocarveol + NAD(+)"}
{"X":24705,"RHEA_ID":21836,"DIRECTION":"UN","MASTER_ID":21836,"ec":"4.2.1.5","compounds":"D-arabinonate = 2-dehydro-3-deoxy-D-arabinonate + H2O"}
{"X":24706,"RHEA_ID":21837,"DIRECTION":"LR","MASTER_ID":21836,"metacyc":"ARABINONATE-DEHYDRATASE-RXN","compounds":"D-arabinonate => 2-dehydro-3-deoxy-D-arabinonate + H2O"}
{"X":24707,"RHEA_ID":21838,"compounds":"2-dehydro-3-deoxy-D-arabinonate + H2O => D-arabinonate"}
{"X":24708,"RHEA_ID":32425,"DIRECTION":"RL","MASTER_ID":32423,"metacyc":"RXN-9403","compounds":"(R)-carvone + AH2 => (1R,4R)-dihydrocarvone + A"}
{"X":24709,"RHEA_ID":42389,"DIRECTION":"LR","MASTER_ID":42388,"metacyc":"RXN-8472","compounds":"beta-D-glucosyl crocetin + UDP-alpha-D-glucose => beta-D-gentiobiosyl crocetin + H(+) + UDP"}
{"X":24710,"RHEA_ID":21841,"compounds":"N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine"}
{"X":24711,"RHEA_ID":21842,"compounds":"H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-methionine"}
{"X":24712,"RHEA_ID":21843,"compounds":"N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine"}
{"X":24713,"RHEA_ID":21844,"DIRECTION":"UN","MASTER_ID":21844,"ec":"2.3.1.14","compounds":"L-glutamine + phenylacetyl-CoA = CoA + H(+) + N(2)-phenylacetyl-L-glutamine"}
{"X":24714,"RHEA_ID":21845,"DIRECTION":"LR","MASTER_ID":21844,"metacyc":"RXN-10850","reactome":"R-HSA-177160.2","compounds":"L-glutamine + phenylacetyl-CoA => CoA + H(+) + N(2)-phenylacetyl-L-glutamine"}
{"X":24715,"RHEA_ID":21846,"compounds":"CoA + H(+) + N(2)-phenylacetyl-L-glutamine => L-glutamine + phenylacetyl-CoA"}
{"X":24716,"RHEA_ID":32433,"compounds":"(4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+) => (1R,4S)-menthone + H(+) + NADPH + O2"}
{"X":24717,"RHEA_ID":42397,"DIRECTION":"LR","MASTER_ID":42396,"metacyc":"RXN-11868","compounds":"cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine => 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 H(+) + 2 S-adenosyl-L-homocysteine"}
{"X":24718,"RHEA_ID":21849,"compounds":"(E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide => (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide"}
{"X":24719,"RHEA_ID":21850,"compounds":"(Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide => (E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide"}
{"X":24720,"RHEA_ID":32437,"compounds":"4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+) => dihydrocarvone + H(+) + NADPH + O2"}
{"X":24721,"RHEA_ID":32438,"compounds":"dihydrocarvone + H(+) + NADPH + O2 <=> 4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)"}
{"X":24722,"RHEA_ID":21853,"compounds":"(R)-10-hydroxyoctadecanoate => (9Z)-octadecenoate + H2O"}
{"X":24723,"RHEA_ID":21854,"compounds":"(9Z)-octadecenoate + H2O => (R)-10-hydroxyoctadecanoate"}
{"X":24724,"RHEA_ID":32441,"compounds":"albaflavenone + 3 H2O + 2 NADP(+) => (+)-epi-isozizaene + 2 H(+) + 2 NADPH + 2 O2"}
{"X":24725,"RHEA_ID":21856,"DIRECTION":"UN","MASTER_ID":21856,"ec":"4.2.1.100","compounds":"cyclohexa-1,5-diene-1-carbonyl-CoA + H2O = 6-hydroxycyclohex-1-ene-1-carbonyl-CoA"}
{"X":24726,"RHEA_ID":21857,"compounds":"cyclohexa-1,5-diene-1-carbonyl-CoA + H2O => 6-hydroxycyclohex-1-ene-1-carbonyl-CoA"}
{"X":24727,"RHEA_ID":21858,"compounds":"6-hydroxycyclohex-1-ene-1-carbonyl-CoA => cyclohexa-1,5-diene-1-carbonyl-CoA + H2O"}
{"X":24728,"RHEA_ID":32445,"compounds":"all-trans-violaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => all-trans-zeaxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]"}
{"X":24729,"RHEA_ID":21861,"DIRECTION":"LR","MASTER_ID":21860,"metacyc":"2.8.2.28-RXN","compounds":"3'-phosphoadenylyl sulfate + quercetin 3,3'-bissulfate => adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3',7-trissulfate"}
{"X":24730,"RHEA_ID":21862,"compounds":"adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3',7-trissulfate => 3'-phosphoadenylyl sulfate + quercetin 3,3'-bissulfate"}
{"X":24731,"RHEA_ID":32453,"compounds":"all-trans-phytoene + 2 diphosphate => 2 all-trans-geranylgeranyl diphosphate"}
{"X":24732,"RHEA_ID":42413,"DIRECTION":"LR","MASTER_ID":42412,"metacyc":"RXN-20986","compounds":"(2R)-2,3-bisphosphoglycerate + ATP + H(+) => ADP + cyclic (2R)-2,3-bisphosphoglycerate + phosphate"}
{"X":24733,"RHEA_ID":21865,"DIRECTION":"LR","MASTER_ID":21864,"metacyc":"RXN-7919","compounds":"an S-(2-hydroxyacyl)glutathione + H2O => a 2-hydroxy carboxylate + glutathione + H(+)"}
{"X":24734,"RHEA_ID":21866,"compounds":"a 2-hydroxy carboxylate + glutathione + H(+) => an S-(2-hydroxyacyl)glutathione + H2O"}
{"X":24735,"RHEA_ID":21868,"DIRECTION":"UN","MASTER_ID":21868,"ec":"3.5.4.26","compounds":"2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O = 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)"}
{"X":24736,"RHEA_ID":21869,"DIRECTION":"LR","MASTER_ID":21868,"ecocyc":"RIBOFLAVINSYNDEAM-RXN","metacyc":"RIBOFLAVINSYNDEAM-RXN","compounds":"2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O => 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)"}
{"X":24737,"RHEA_ID":21870,"compounds":"5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+) => 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O"}
{"X":24738,"RHEA_ID":32461,"compounds":"H(+) + precorrin-2 + 2 S-adenosyl-L-homocysteine => 2 S-adenosyl-L-methionine + uroporphyrinogen III"}
{"X":24739,"RHEA_ID":42421,"compounds":"2-oxoglutarate + L-lysine + O2 => (4R)-4-hydroxy-L-lysine + CO2 + succinate"}
{"X":24740,"RHEA_ID":21873,"DIRECTION":"LR","MASTER_ID":21872,"metacyc":"2.1.1.124-RXN","compounds":"L-arginyl-[cytochrome c] + S-adenosyl-L-methionine => H(+) + N(omega)-methyl-L-arginyl-[cytochrome c] + S-adenosyl-L-homocysteine"}
{"X":24741,"RHEA_ID":21874,"compounds":"H(+) + N(omega)-methyl-L-arginyl-[cytochrome c] + S-adenosyl-L-homocysteine => L-arginyl-[cytochrome c] + S-adenosyl-L-methionine"}
{"X":24742,"RHEA_ID":32465,"compounds":"2 H(+) + N,N-dimethylglycine + 2 S-adenosyl-L-homocysteine => glycine + 2 S-adenosyl-L-methionine"}
{"X":24743,"RHEA_ID":42425,"DIRECTION":"LR","MASTER_ID":42424,"metacyc":"RXN-7744","compounds":"2-methylmaleate + H2O => (2R,3S)-3-methylmalate"}
{"X":24744,"RHEA_ID":21877,"compounds":"(6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD(+) => (S)-usnate + 2 H(+) + NADH"}
{"X":24745,"RHEA_ID":21878,"compounds":"(S)-usnate + 2 H(+) + NADH => (6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD(+)"}
{"X":24746,"RHEA_ID":32469,"compounds":"betaine + 2 H(+) + 2 S-adenosyl-L-homocysteine => 2 S-adenosyl-L-methionine + sarcosine"}
{"X":24747,"RHEA_ID":21880,"DIRECTION":"UN","MASTER_ID":21880,"ec":"1.2.3.4","compounds":"2 H(+) + O2 + oxalate = 2 CO2 + H2O2"}
{"X":24748,"RHEA_ID":21881,"DIRECTION":"LR","MASTER_ID":21880,"metacyc":"OXALATE-OXIDASE-RXN","compounds":"2 H(+) + O2 + oxalate => 2 CO2 + H2O2"}
{"X":24749,"RHEA_ID":21882,"compounds":"2 CO2 + H2O2 => 2 H(+) + O2 + oxalate"}
{"X":24750,"RHEA_ID":21884,"DIRECTION":"UN","MASTER_ID":21884,"ec":"3.12.1.1","compounds":"H2O + trithionate = H(+) + sulfate + thiosulfate"}
{"X":24751,"RHEA_ID":21885,"compounds":"H2O + trithionate => H(+) + sulfate + thiosulfate"}
{"X":24752,"RHEA_ID":32476,"DIRECTION":"LR","MASTER_ID":32475,"metacyc":"RXN-13406","compounds":"glycine + 3 S-adenosyl-L-methionine => betaine + 3 H(+) + 3 S-adenosyl-L-homocysteine"}
{"X":24753,"RHEA_ID":21888,"DIRECTION":"UN","MASTER_ID":21888,"ec":"1.3.1.42","compounds":"NADP(+) + OPC-8 = (10Z,15Z)-12-oxophytodienoate + H(+) + NADPH"}
{"X":24754,"RHEA_ID":21889,"compounds":"NADP(+) + OPC-8 => (10Z,15Z)-12-oxophytodienoate + H(+) + NADPH"}
{"X":24755,"RHEA_ID":32480,"compounds":"2 iodide + L-tyrosine + 2 NADP(+) => 3,5-diiodo-L-tyrosine + H(+) + 2 NADPH"}
{"X":24756,"RHEA_ID":32481,"DIRECTION":"RL","MASTER_ID":32479,"metacyc":"RXN-13402","compounds":"3,5-diiodo-L-tyrosine + H(+) + 2 NADPH => 2 iodide + L-tyrosine + 2 NADP(+)"}
{"X":24757,"RHEA_ID":21892,"DIRECTION":"UN","MASTER_ID":21892,"ec":"1.1.1.117","compounds":"D-arabinose + NADP(+) = D-arabinono-1,4-lactone + H(+) + NADPH"}
{"X":24758,"RHEA_ID":21893,"DIRECTION":"LR","MASTER_ID":21892,"metacyc":"1.1.1.117-RXN","compounds":"D-arabinose + NADP(+) => D-arabinono-1,4-lactone + H(+) + NADPH"}
{"X":24759,"RHEA_ID":32484,"DIRECTION":"LR","MASTER_ID":32483,"metacyc":"3.1.1.82-RXN","compounds":"H(+) + H2O + pheophorbide a => CO2 + methanol + pyropheophorbide a"}
{"X":24760,"RHEA_ID":21894,"compounds":"D-arabinono-1,4-lactone + H(+) + NADPH => D-arabinose + NADP(+)"}
{"X":24761,"RHEA_ID":42445,"compounds":"L-aspartate + NADP(+) => H(+) + iminosuccinate + NADPH"}
{"X":24762,"RHEA_ID":21896,"DIRECTION":"UN","MASTER_ID":21896,"ec":"6.3.1.10","compounds":"(R)-1-aminopropan-2-yl phosphate + adenosylcob(III)yrate + ATP = adenosylcob(III)inamide phosphate + ADP + H(+) + phosphate"}
{"X":24763,"RHEA_ID":32488,"compounds":"CDP-choline + H2O => CMP + 2 H(+) + phosphocholine"}
{"X":24764,"RHEA_ID":21898,"compounds":"adenosylcob(III)inamide phosphate + ADP + H(+) + phosphate => (R)-1-aminopropan-2-yl phosphate + adenosylcob(III)yrate + ATP"}
{"X":24765,"RHEA_ID":42449,"DIRECTION":"LR","MASTER_ID":42448,"metacyc":"RXN-1083","compounds":"(R)-2-hydroxyglutaryl-CoA => (2E)-glutaconyl-CoA + H2O"}
{"X":24766,"RHEA_ID":21904,"DIRECTION":"UN","MASTER_ID":21904,"ec":"5.4.2.11","compounds":"(2R)-2,3-bisphosphoglycerate + H2O = (2R)-3-phosphoglycerate + phosphate"}
{"X":24767,"RHEA_ID":32492,"DIRECTION":"LR","MASTER_ID":32491,"metacyc":"RXN-10628","compounds":"(1E,4E,8E)-alpha-humulene + O2 + reduced [NADPH--hemoprotein reductase] => 10-hydroxy-alpha-humulene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":24768,"RHEA_ID":21906,"compounds":"(2R)-3-phosphoglycerate + phosphate => (2R)-2,3-bisphosphoglycerate + H2O"}
{"X":24769,"RHEA_ID":42453,"DIRECTION":"LR","MASTER_ID":42452,"ecocyc":"RXN-10720","metacyc":"RXN-10720","reactome":"R-HSA-893597.1","compounds":"4-(2-aminophenyl)-2,4-dioxobutanoate => H2O + kynurenate"}
{"X":24770,"RHEA_ID":21908,"DIRECTION":"UN","MASTER_ID":21908,"ec":"1.1.1.252","compounds":"NADP(+) + scytalone = H(+) + NADPH + naphthalene-1,3,6,8-tetrol"}
{"X":24771,"RHEA_ID":21909,"compounds":"NADP(+) + scytalone => H(+) + NADPH + naphthalene-1,3,6,8-tetrol"}
{"X":24772,"RHEA_ID":21910,"compounds":"H(+) + NADPH + naphthalene-1,3,6,8-tetrol => NADP(+) + scytalone"}
{"X":24773,"RHEA_ID":42456,"compounds":"4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol = 5alpha-cholesta-8,24-dien-3beta-ol"}
{"X":24774,"RHEA_ID":21912,"DIRECTION":"UN","MASTER_ID":21912,"ec":"1.2.3.6","compounds":"CoA + H(+) + O2 + pyruvate = acetyl-CoA + CO2 + H2O2"}
{"X":24775,"RHEA_ID":32500,"compounds":"(1R,5R)-sabinene + H(+) + NADPH + O2 => (1S,3R,5S)-sabinol + H2O + NADP(+)"}
{"X":24776,"RHEA_ID":21914,"compounds":"acetyl-CoA + CO2 + H2O2 => CoA + H(+) + O2 + pyruvate"}
{"X":24777,"RHEA_ID":42460,"compounds":"dibenzofuran + H(+) + NADH + O2 = biphenyl-2,2',3-triol + NAD(+)"}
{"X":24778,"RHEA_ID":21916,"compounds":"2 [Fe(III)cytochrome c550] + an aliphatic amine + H2O = 2 [Fe(II)cytochrome c550] + an aldehyde + 2 H(+) + NH4(+)"}
{"X":24779,"RHEA_ID":32504,"DIRECTION":"LR","MASTER_ID":32503,"metacyc":"LINALOOL-8-MONOOXYGENASE-RXN","compounds":"linalool + O2 + reduced [NADPH--hemoprotein reductase] => (6E)-8-hydroxylinalool + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":24780,"RHEA_ID":21918,"compounds":"2 [Fe(II)cytochrome c550] + an aldehyde + 2 H(+) + NH4(+) => 2 [Fe(III)cytochrome c550] + an aliphatic amine + H2O"}
{"X":24781,"RHEA_ID":21919,"DIRECTION":"BI","MASTER_ID":21916,"metacyc":"AMINE-DEHYDROGENASE-RXN","compounds":"2 [Fe(III)cytochrome c550] + an aliphatic amine + H2O <=> 2 [Fe(II)cytochrome c550] + an aldehyde + 2 H(+) + NH4(+)"}
{"X":24782,"RHEA_ID":21920,"DIRECTION":"UN","MASTER_ID":21920,"ec":"2.7.8.13","compounds":"di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine = Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + UMP"}
{"X":24783,"RHEA_ID":32508,"compounds":"4-isopropenyl-7-methyloxepan-2-one + H2O => 6-hydroxy-3-isopropenylheptanoate + H(+)"}
{"X":24784,"RHEA_ID":21922,"compounds":"Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + UMP => di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine"}
{"X":24785,"RHEA_ID":32510,"DIRECTION":"BI","MASTER_ID":32507,"metacyc":"RXN-9393","compounds":"4-isopropenyl-7-methyloxepan-2-one + H2O <=> 6-hydroxy-3-isopropenylheptanoate + H(+)"}
{"X":24786,"RHEA_ID":21924,"DIRECTION":"UN","MASTER_ID":21924,"ec":"1.1.1.130","compounds":"3-dehydro-L-gulonate + NAD(+) = 2,3-dioxo-L-gulonate + H(+) + NADH"}
{"X":24787,"RHEA_ID":32512,"DIRECTION":"LR","MASTER_ID":32511,"metacyc":"RXN-9394","compounds":"(4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O => (3R,6R)-6-hydroxy-3-isopropenylheptanoate + H(+)"}
{"X":24788,"RHEA_ID":21926,"DIRECTION":"RL","MASTER_ID":21924,"ecocyc":"RXN0-703","metacyc":"RXN0-703","compounds":"2,3-dioxo-L-gulonate + H(+) + NADH => 3-dehydro-L-gulonate + NAD(+)"}
{"X":24789,"RHEA_ID":42472,"compounds":"dibenzo-p-dioxin + NADH + O2 = 2,2',3-trihydroxydiphenyl ether + H(+) + NAD(+)"}
{"X":24790,"RHEA_ID":21928,"DIRECTION":"UN","MASTER_ID":21928,"ec":"1.1.1.130","compounds":"3-dehydro-L-gulonate + NADP(+) = 2,3-dioxo-L-gulonate + H(+) + NADPH"}
{"X":24791,"RHEA_ID":21929,"compounds":"3-dehydro-L-gulonate + NADP(+) => 2,3-dioxo-L-gulonate + H(+) + NADPH"}
{"X":24792,"RHEA_ID":21930,"compounds":"2,3-dioxo-L-gulonate + H(+) + NADPH => 3-dehydro-L-gulonate + NADP(+)"}
{"X":24793,"RHEA_ID":42476,"compounds":"2,2',3-trihydroxydiphenyl ether + H(+) + O2 = 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate"}
{"X":24794,"RHEA_ID":21932,"DIRECTION":"UN","MASTER_ID":21932,"ec":"2.5.1.4","compounds":"S-adenosyl-L-methionine = homoserine lactone + S-methyl-5'-thioadenosine"}
{"X":24795,"RHEA_ID":32520,"DIRECTION":"LR","MASTER_ID":32519,"metacyc":"RXN-12975","compounds":"(2E)-geranyl diphosphate + S-adenosyl-L-methionine => (E)-2-methylgeranyl diphosphate + H(+) + S-adenosyl-L-homocysteine"}
{"X":24796,"RHEA_ID":21934,"compounds":"homoserine lactone + S-methyl-5'-thioadenosine => S-adenosyl-L-methionine"}
{"X":24797,"RHEA_ID":42480,"compounds":"2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + catechol + H(+)"}
{"X":24798,"RHEA_ID":21936,"DIRECTION":"UN","MASTER_ID":21936,"ec":"2.1.3.6","compounds":"carbamoyl phosphate + putrescine = H(+) + N-carbamoylputrescine + phosphate"}
{"X":24799,"RHEA_ID":32524,"compounds":"nigerose + phosphate => beta-D-glucose 1-phosphate + D-glucose"}
{"X":24800,"RHEA_ID":21938,"compounds":"H(+) + N-carbamoylputrescine + phosphate => carbamoyl phosphate + putrescine"}
{"X":24801,"RHEA_ID":42484,"DIRECTION":"UN","MASTER_ID":42484,"ec":"2.7.1.198","compounds":"D-sorbitol(out) + N(pros)-phospho-L-histidyl-[protein] = D-sorbitol 6-phosphate(in) + L-histidyl-[protein]"}
{"X":24802,"RHEA_ID":21940,"compounds":"AH2 + O2 + squalene = (S)-2,3-epoxysqualene + A + H2O"}
{"X":24803,"RHEA_ID":32528,"compounds":"N,N'-diacetylchitobiose + phosphate => N-acetyl-alpha-D-glucosamine 1-phosphate + N-acetyl-D-glucosamine"}
{"X":24804,"RHEA_ID":21942,"compounds":"(S)-2,3-epoxysqualene + A + H2O => AH2 + O2 + squalene"}
{"X":24805,"RHEA_ID":21944,"DIRECTION":"UN","MASTER_ID":21944,"ec":"2.7.1.85","compounds":"ATP + D-cellobiose = 6-phospho-beta-D-glucosyl-(1->4)-D-glucose + ADP + H(+)"}
{"X":24806,"RHEA_ID":32532,"compounds":"4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate => alpha-D-mannose 1-phosphate + D-glucose"}
{"X":24807,"RHEA_ID":21946,"compounds":"6-phospho-beta-D-glucosyl-(1->4)-D-glucose + ADP + H(+) => ATP + D-cellobiose"}
{"X":24808,"RHEA_ID":42492,"compounds":"3'-N-debenzoyl-2'-deoxytaxol + AH2 + O2 = 3'-N-debenzoyltaxol + A + H2O"}
{"X":24809,"RHEA_ID":21948,"DIRECTION":"UN","MASTER_ID":21948,"ec":"3.5.1.49","compounds":"formamide + H2O = formate + NH4(+)"}
{"X":24810,"RHEA_ID":32536,"DIRECTION":"LR","MASTER_ID":32535,"metacyc":"RXN-12734","compounds":"(2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H2O => 4-hydroxy-2-oxohexanoate"}
{"X":24811,"RHEA_ID":21950,"compounds":"formate + NH4(+) => formamide + H2O"}
{"X":24812,"RHEA_ID":21952,"DIRECTION":"UN","MASTER_ID":21952,"ec":"1.3.1.22","compounds":"5alpha-pregnane-3,20-dione + NADP(+) = H(+) + NADPH + progesterone"}
{"X":24813,"RHEA_ID":21953,"compounds":"5alpha-pregnane-3,20-dione + NADP(+) => H(+) + NADPH + progesterone"}
{"X":24814,"RHEA_ID":21954,"DIRECTION":"RL","MASTER_ID":21952,"metacyc":"PROGESTERONE-5-ALPHA-REDUCTASE-RXN","compounds":"H(+) + NADPH + progesterone => 5alpha-pregnane-3,20-dione + NADP(+)"}
{"X":24815,"RHEA_ID":42500,"compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) = 6-lactoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH"}
{"X":24816,"RHEA_ID":21956,"DIRECTION":"UN","MASTER_ID":21956,"ec":"2.4.1.105","compounds":"UDP-alpha-D-glucose + vitexin = H(+) + UDP + vitexin 2''-O-beta-D-glucoside"}
{"X":24817,"RHEA_ID":32544,"DIRECTION":"LR","MASTER_ID":32543,"metacyc":"RXN-12980","compounds":"(2E)-geranyl diphosphate + H2O => 1,8-cineole + diphosphate"}
{"X":24818,"RHEA_ID":21958,"compounds":"H(+) + UDP + vitexin 2''-O-beta-D-glucoside => UDP-alpha-D-glucose + vitexin"}
{"X":24819,"RHEA_ID":42504,"compounds":"2-oxoglutarate + N(6)-acetyl-L-lysine = 6-acetamido-2-oxohexanoate + L-glutamate"}
{"X":24820,"RHEA_ID":21960,"compounds":"(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + [protein]-disulfide + H(+) + H2O = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + [protein]-dithiol"}
{"X":24821,"RHEA_ID":32548,"DIRECTION":"LR","MASTER_ID":32547,"metacyc":"RXN-12982","compounds":"(2E)-geranyl diphosphate => (1R,5R)-sabinene + diphosphate"}
{"X":24822,"RHEA_ID":21962,"compounds":"2-C-methyl-D-erythritol 2,4-cyclic diphosphate + [protein]-dithiol => (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + [protein]-disulfide + H(+) + H2O"}
{"X":24823,"RHEA_ID":21963,"compounds":"(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + [protein]-disulfide + H(+) + H2O <=> 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + [protein]-dithiol"}
{"X":24824,"RHEA_ID":21964,"DIRECTION":"UN","MASTER_ID":21964,"ec":"3.1.1.8","compounds":"an acylcholine + H2O = a carboxylate + choline + H(+)"}
{"X":24825,"RHEA_ID":32552,"DIRECTION":"LR","MASTER_ID":32551,"metacyc":"RXN-5101","compounds":"(2E)-geranyl diphosphate + H2O => (S)-alpha-terpineol + diphosphate"}
{"X":24826,"RHEA_ID":21966,"compounds":"a carboxylate + choline + H(+) => an acylcholine + H2O"}
{"X":24827,"RHEA_ID":21968,"DIRECTION":"UN","MASTER_ID":21968,"ec":"4.2.3.4","compounds":"7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate"}
{"X":24828,"RHEA_ID":21969,"DIRECTION":"LR","MASTER_ID":21968,"ecocyc":"3-DEHYDROQUINATE-SYNTHASE-RXN","macie":"M0059","metacyc":"3-DEHYDROQUINATE-SYNTHASE-RXN","compounds":"7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate => 3-dehydroquinate + phosphate"}
{"X":24829,"RHEA_ID":21970,"compounds":"3-dehydroquinate + phosphate => 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate"}
{"X":24830,"RHEA_ID":42516,"compounds":"H2O + L-gulono-1,4-lactone = H(+) + L-gulonate"}
{"X":24831,"RHEA_ID":21972,"compounds":"precorrin-1 + S-adenosyl-L-methionine = precorrin-2 + S-adenosyl-L-homocysteine"}
{"X":24832,"RHEA_ID":21973,"DIRECTION":"LR","MASTER_ID":21972,"ecocyc":"RXN-8675","metacyc":"RXN-8675","compounds":"precorrin-1 + S-adenosyl-L-methionine => precorrin-2 + S-adenosyl-L-homocysteine"}
{"X":24833,"RHEA_ID":21974,"compounds":"precorrin-2 + S-adenosyl-L-homocysteine => precorrin-1 + S-adenosyl-L-methionine"}
{"X":24834,"RHEA_ID":42520,"DIRECTION":"UN","MASTER_ID":42520,"ec":"5.4.99.22","compounds":"23S rRNA uridine(2605) = 23S rRNA pseudouridine(2605)"}
{"X":24835,"RHEA_ID":21976,"DIRECTION":"UN","MASTER_ID":21976,"ec":"1.8.4.10","compounds":"[thioredoxin]-disulfide + AMP + 2 H(+) + sulfite = [thioredoxin]-dithiol + adenosine 5'-phosphosulfate"}
{"X":24836,"RHEA_ID":21977,"compounds":"[thioredoxin]-disulfide + AMP + 2 H(+) + sulfite => [thioredoxin]-dithiol + adenosine 5'-phosphosulfate"}
{"X":24837,"RHEA_ID":21978,"DIRECTION":"RL","MASTER_ID":21976,"metacyc":"RXN-12019","compounds":"[thioredoxin]-dithiol + adenosine 5'-phosphosulfate => [thioredoxin]-disulfide + AMP + 2 H(+) + sulfite"}
{"X":24838,"RHEA_ID":52507,"compounds":"(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 9(R)-hydroxy-(10E,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":24839,"RHEA_ID":21980,"DIRECTION":"UN","MASTER_ID":21980,"ec":"2.8.2.8","compounds":"3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = adenosine 3',5'-bisphosphate + 2 H(+) + N-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n)"}
{"X":24840,"RHEA_ID":21981,"compounds":"3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) => adenosine 3',5'-bisphosphate + 2 H(+) + N-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n)"}
{"X":24841,"RHEA_ID":21982,"compounds":"adenosine 3',5'-bisphosphate + 2 H(+) + N-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) => 3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n)"}
{"X":24842,"RHEA_ID":42528,"DIRECTION":"UN","MASTER_ID":42528,"ec":"5.4.99.24","compounds":"uridine(955/2504/2580) in 23S rRNA = pseudouridine(955/2504/2580) in 23S rRNA"}
{"X":24843,"RHEA_ID":21984,"DIRECTION":"UN","MASTER_ID":21984,"ec":"2.8.2.6","metacyc":"CHOLINE-SULFOTRANSFERASE-RXN","compounds":"3'-phosphoadenylyl sulfate + choline = adenosine 3',5'-bisphosphate + choline sulfate + H(+)"}
{"X":24844,"RHEA_ID":21985,"compounds":"3'-phosphoadenylyl sulfate + choline => adenosine 3',5'-bisphosphate + choline sulfate + H(+)"}
{"X":24845,"RHEA_ID":21986,"compounds":"adenosine 3',5'-bisphosphate + choline sulfate + H(+) => 3'-phosphoadenylyl sulfate + choline"}
{"X":24846,"RHEA_ID":25336,"compounds":"H(+) + L-cysteine + tRNA(Cys) => H2O + L-cysteinyl-tRNA(Cys)"}
{"X":24847,"RHEA_ID":21988,"DIRECTION":"UN","MASTER_ID":21988,"ec":"2.3.1.172","compounds":"malonyl-CoA + pelargonidin 3-O-(6-O-[(E)-caffeoyl]-beta-D-glucoside) 5-O-beta-D-glucoside = 4'''-demalonylsalvianin + CoA"}
{"X":24848,"RHEA_ID":21989,"DIRECTION":"LR","MASTER_ID":21988,"metacyc":"2.3.1.172-RXN","compounds":"malonyl-CoA + pelargonidin 3-O-(6-O-[(E)-caffeoyl]-beta-D-glucoside) 5-O-beta-D-glucoside => 4'''-demalonylsalvianin + CoA"}
{"X":24849,"RHEA_ID":21990,"compounds":"4'''-demalonylsalvianin + CoA => malonyl-CoA + pelargonidin 3-O-(6-O-[(E)-caffeoyl]-beta-D-glucoside) 5-O-beta-D-glucoside"}
{"X":24850,"RHEA_ID":42536,"DIRECTION":"UN","MASTER_ID":42536,"ec":"5.4.99.26","compounds":"uridine(65) in tRNA = pseudouridine(65) in tRNA"}
{"X":24851,"RHEA_ID":21992,"DIRECTION":"UN","MASTER_ID":21992,"ec":"2.3.1.48","compounds":"acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone]"}
{"X":24852,"RHEA_ID":21993,"DIRECTION":"LR","MASTER_ID":21992,"metacyc":"HISTONE-ACETYLTRANSFERASE-RXN","compounds":"acetyl-CoA + L-lysyl-[histone] => CoA + H(+) + N(6)-acetyl-L-lysyl-[histone]"}
{"X":24853,"RHEA_ID":21994,"compounds":"CoA + H(+) + N(6)-acetyl-L-lysyl-[histone] => acetyl-CoA + L-lysyl-[histone]"}
{"X":24854,"RHEA_ID":52523,"compounds":"O2 + prostaglandin E1 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy prostaglandin E1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":24855,"RHEA_ID":21996,"DIRECTION":"UN","MASTER_ID":21996,"ec":"2.3.1.125","metacyc":"2.3.1.125-RXN","compounds":"a 1-O-alkyl-2-acetyl-sn-glycerol + an acyl-CoA = a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + CoA"}
{"X":24856,"RHEA_ID":21997,"compounds":"a 1-O-alkyl-2-acetyl-sn-glycerol + an acyl-CoA => a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + CoA"}
{"X":24857,"RHEA_ID":21998,"compounds":"a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + CoA => a 1-O-alkyl-2-acetyl-sn-glycerol + an acyl-CoA"}
{"X":24858,"RHEA_ID":32586,"compounds":"dihydrocarvone + H(+) + NADPH + O2 <=> 6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)"}
{"X":24859,"RHEA_ID":22000,"DIRECTION":"UN","MASTER_ID":22000,"ec":"1.1.1.179","compounds":"D-xylose + NADP(+) = D-xylono-1,5-lactone + H(+) + NADPH"}
{"X":24860,"RHEA_ID":22000,"DIRECTION":"UN","MASTER_ID":22000,"ec":"1.1.1.359","compounds":"D-xylose + NADP(+) = D-xylono-1,5-lactone + H(+) + NADPH"}
{"X":24861,"RHEA_ID":22001,"compounds":"D-xylose + NADP(+) => D-xylono-1,5-lactone + H(+) + NADPH"}
{"X":24862,"RHEA_ID":22002,"compounds":"D-xylono-1,5-lactone + H(+) + NADPH => D-xylose + NADP(+)"}
{"X":24863,"RHEA_ID":32591,"DIRECTION":"UN","MASTER_ID":32591,"ec":"3.1.1.83","compounds":"(4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O = (3R,6S)-6-hydroxy-3,7-dimethyloctanoate + H(+)"}
{"X":24864,"RHEA_ID":22004,"DIRECTION":"UN","MASTER_ID":22004,"ec":"2.7.11.18","compounds":"[myosin light chain]-L-serine + ATP = [myosin light chain]-O-phospho-L-serine + ADP + H(+)"}
{"X":24865,"RHEA_ID":22005,"compounds":"[myosin light chain]-L-serine + ATP => [myosin light chain]-O-phospho-L-serine + ADP + H(+)"}
{"X":24866,"RHEA_ID":32594,"compounds":"(4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O <=> (3R,6S)-6-hydroxy-3,7-dimethyloctanoate + H(+)"}
{"X":24867,"RHEA_ID":32595,"DIRECTION":"UN","MASTER_ID":32595,"ec":"3.1.1.83","compounds":"7-isopropyl-4-methyloxepan-2-one + H2O = 6-hydroxy-3,7-dimethyloctanoate + H(+)"}
{"X":24868,"RHEA_ID":22008,"DIRECTION":"UN","MASTER_ID":22008,"ec":"2.3.1.46","compounds":"L-homoserine + succinyl-CoA = CoA + O-succinyl-L-homoserine"}
{"X":24869,"RHEA_ID":22009,"DIRECTION":"LR","MASTER_ID":22008,"ecocyc":"HOMSUCTRAN-RXN","metacyc":"HOMSUCTRAN-RXN","compounds":"L-homoserine + succinyl-CoA => CoA + O-succinyl-L-homoserine"}
{"X":24870,"RHEA_ID":32598,"DIRECTION":"BI","MASTER_ID":32595,"metacyc":"RXN-9984","compounds":"7-isopropyl-4-methyloxepan-2-one + H2O <=> 6-hydroxy-3,7-dimethyloctanoate + H(+)"}
{"X":24871,"RHEA_ID":32599,"compounds":"7-hydroxy-4-isopropenyl-7-methyloxepan-2-one = 3-isopropenyl-6-oxoheptanoate + H(+)"}
{"X":24872,"RHEA_ID":22012,"DIRECTION":"UN","MASTER_ID":22012,"ec":"2.1.1.133","compounds":"precorrin-4 + S-adenosyl-L-methionine = precorrin-5 + S-adenosyl-L-homocysteine"}
{"X":24873,"RHEA_ID":22013,"DIRECTION":"LR","MASTER_ID":22012,"metacyc":"2.1.1.133-RXN","compounds":"precorrin-4 + S-adenosyl-L-methionine => precorrin-5 + S-adenosyl-L-homocysteine"}
{"X":24874,"RHEA_ID":32602,"compounds":"7-hydroxy-4-isopropenyl-7-methyloxepan-2-one <=> 3-isopropenyl-6-oxoheptanoate + H(+)"}
{"X":24875,"RHEA_ID":32603,"compounds":"(6E)-8-hydroxygeraniol + NADP(+) = (6E)-8-oxogeraniol + H(+) + NADPH"}
{"X":24876,"RHEA_ID":22016,"DIRECTION":"UN","MASTER_ID":22016,"ec":"1.20.4.1","compounds":"[glutaredoxin]-dithiol + arsenate + H(+) = [glutaredoxin]-disulfide + arsenite + H2O"}
{"X":24877,"RHEA_ID":22017,"compounds":"[glutaredoxin]-dithiol + arsenate + H(+) => [glutaredoxin]-disulfide + arsenite + H2O"}
{"X":24878,"RHEA_ID":22018,"compounds":"[glutaredoxin]-disulfide + arsenite + H2O => [glutaredoxin]-dithiol + arsenate + H(+)"}
{"X":24879,"RHEA_ID":22020,"DIRECTION":"UN","MASTER_ID":22020,"ec":"7.3.2.5","compounds":"ATP + H2O + molybdate(out) = ADP + H(+) + molybdate(in) + phosphate"}
{"X":24880,"RHEA_ID":22021,"DIRECTION":"LR","MASTER_ID":22020,"ecocyc":"ABC-19-RXN","metacyc":"3.6.3.29-RXN","compounds":"ATP + H2O + molybdate(out) => ADP + H(+) + molybdate(in) + phosphate"}
{"X":24881,"RHEA_ID":22022,"compounds":"ADP + H(+) + molybdate(in) + phosphate => ATP + H2O + molybdate(out)"}
{"X":24882,"RHEA_ID":22023,"compounds":"ATP + H2O + molybdate(out) <=> ADP + H(+) + molybdate(in) + phosphate"}
{"X":24883,"RHEA_ID":22024,"DIRECTION":"UN","MASTER_ID":22024,"ec":"1.7.2.3","compounds":"H2O + NAD(+) + trimethylamine = 2 H(+) + NADH + trimethylamine N-oxide"}
{"X":24884,"RHEA_ID":22025,"compounds":"H2O + NAD(+) + trimethylamine => 2 H(+) + NADH + trimethylamine N-oxide"}
{"X":24885,"RHEA_ID":42572,"compounds":"3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+) = 2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + CO2"}
{"X":24886,"RHEA_ID":22028,"DIRECTION":"UN","MASTER_ID":22028,"ec":"2.3.1.162","compounds":"acetyl-CoA + taxa-4(20),11-dien-5alpha-ol = CoA + taxa-4(20),11-dien-5alpha-yl acetate"}
{"X":24887,"RHEA_ID":22029,"compounds":"acetyl-CoA + taxa-4(20),11-dien-5alpha-ol => CoA + taxa-4(20),11-dien-5alpha-yl acetate"}
{"X":24888,"RHEA_ID":42576,"compounds":"2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + H2O = 2-methylpropanoate + 2-oxopent-4-enoate + H(+)"}
{"X":24889,"RHEA_ID":32619,"DIRECTION":"UN","MASTER_ID":32619,"ec":"1.1.1.325","compounds":"L-threo-7,8-dihydrobiopterin + NADP(+) = H(+) + NADPH + sepiapterin"}
{"X":24890,"RHEA_ID":22032,"DIRECTION":"UN","MASTER_ID":22032,"ec":"4.1.3.13","compounds":"3-oxalomalate = glyoxylate + oxaloacetate"}
{"X":24891,"RHEA_ID":22033,"DIRECTION":"LR","MASTER_ID":22032,"metacyc":"OXALOMALATE-LYASE-RXN","compounds":"3-oxalomalate => glyoxylate + oxaloacetate"}
{"X":24892,"RHEA_ID":42580,"DIRECTION":"UN","MASTER_ID":42580,"ec":"6.1.1.11","compounds":"ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)"}
{"X":24893,"RHEA_ID":32623,"DIRECTION":"UN","MASTER_ID":32623,"ec":"1.1.1.325","compounds":"L-threo-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH"}
{"X":24894,"RHEA_ID":22036,"DIRECTION":"UN","MASTER_ID":22036,"ec":"2.7.1.63","compounds":"[phosphate](n) + D-glucose = [phosphate](n-1) + D-glucose 6-phosphate + H(+)"}
{"X":24895,"RHEA_ID":22037,"DIRECTION":"LR","MASTER_ID":22036,"metacyc":"2.7.1.63-RXN","compounds":"[phosphate](n) + D-glucose => [phosphate](n-1) + D-glucose 6-phosphate + H(+)"}
{"X":24896,"RHEA_ID":42584,"compounds":"1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = 1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}
{"X":24897,"RHEA_ID":32627,"DIRECTION":"UN","MASTER_ID":32627,"ec":"1.1.1.153","compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH"}
{"X":24898,"RHEA_ID":22040,"DIRECTION":"UN","MASTER_ID":22040,"ec":"3.5.1.8","metacyc":"FORMYLASPARTATE-DEFORMYLASE-RXN","compounds":"H2O + N-formyl-L-aspartate = formate + L-aspartate"}
{"X":24899,"RHEA_ID":22041,"compounds":"H2O + N-formyl-L-aspartate => formate + L-aspartate"}
{"X":24900,"RHEA_ID":42588,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":24901,"RHEA_ID":32631,"DIRECTION":"UN","MASTER_ID":32631,"ec":"1.14.13.154","compounds":"erythromycin D + H(+) + NADPH + O2 = erythromycin C + H2O + NADP(+)"}
{"X":24902,"RHEA_ID":22044,"DIRECTION":"UN","MASTER_ID":22044,"ec":"7.2.2.19","compounds":"ATP + H(+)(in) + H2O + K(+)(out) = ADP + 2 H(+)(out) + K(+)(in) + phosphate"}
{"X":24903,"RHEA_ID":22045,"DIRECTION":"LR","MASTER_ID":22044,"metacyc":"3.6.3.10-RXN","compounds":"ATP + H(+)(in) + H2O + K(+)(out) => ADP + 2 H(+)(out) + K(+)(in) + phosphate"}
{"X":24904,"RHEA_ID":42592,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":24905,"RHEA_ID":22047,"compounds":"ATP + H(+)(in) + H2O + K(+)(out) <=> ADP + 2 H(+)(out) + K(+)(in) + phosphate"}
{"X":24906,"RHEA_ID":22048,"DIRECTION":"UN","MASTER_ID":22048,"ec":"4.2.3.12","compounds":"7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate"}
{"X":24907,"RHEA_ID":22049,"DIRECTION":"LR","MASTER_ID":22048,"macie":"M0084","metacyc":"4.2.3.12-RXN","compounds":"7,8-dihydroneopterin 3'-triphosphate => 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate"}
{"X":24908,"RHEA_ID":42596,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = prostaglandin G2"}
{"X":24909,"RHEA_ID":32639,"compounds":"(6E)-8-hydroxylinalool + O2 + reduced [NADPH--hemoprotein reductase] = (6E)-8-oxolinalool + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":24910,"RHEA_ID":22052,"DIRECTION":"UN","MASTER_ID":22052,"ec":"1.7.99.1","compounds":"A + H2O + NH4(+) = AH2 + H(+) + hydroxylamine"}
{"X":24911,"RHEA_ID":22053,"compounds":"A + H2O + NH4(+) => AH2 + H(+) + hydroxylamine"}
{"X":24912,"RHEA_ID":42599,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 <=> prostaglandin G2"}
{"X":24913,"RHEA_ID":22056,"DIRECTION":"UN","MASTER_ID":22056,"ec":"1.1.1.164","metacyc":"HEXADECANOL-DEHYDROGENASE-RXN","compounds":"hexadecan-1-ol + NAD(+) = H(+) + hexadecanal + NADH"}
{"X":24914,"RHEA_ID":22057,"compounds":"hexadecan-1-ol + NAD(+) => H(+) + hexadecanal + NADH"}
{"X":24915,"RHEA_ID":42603,"compounds":"AH2 + prostaglandin G2 <=> A + H2O + prostaglandin H2"}
{"X":24916,"RHEA_ID":32647,"DIRECTION":"UN","MASTER_ID":32647,"ec":"2.1.1.254","compounds":"erythromycin C + S-adenosyl-L-methionine = erythromycin A + H(+) + S-adenosyl-L-homocysteine"}
{"X":24917,"RHEA_ID":22060,"DIRECTION":"UN","MASTER_ID":22060,"ec":"2.8.1.6","compounds":"[sulfur carrier]-SH + dethiobiotin + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":24918,"RHEA_ID":22061,"DIRECTION":"LR","MASTER_ID":22060,"ecocyc":"2.8.1.6-RXN","metacyc":"2.8.1.6-RXN","compounds":"[sulfur carrier]-SH + dethiobiotin + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":24919,"RHEA_ID":22062,"compounds":"2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] => [sulfur carrier]-SH + dethiobiotin + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine"}
{"X":24920,"RHEA_ID":32651,"DIRECTION":"UN","MASTER_ID":32651,"ec":"2.1.1.254","compounds":"erythromycin D + S-adenosyl-L-methionine = erythromycin B + H(+) + S-adenosyl-L-homocysteine"}
{"X":24921,"RHEA_ID":22064,"DIRECTION":"UN","MASTER_ID":22064,"ec":"4.2.1.62","compounds":"5alpha-ergosta-7,22-diene-3beta,5-diol = ergosterol + H2O"}
{"X":24922,"RHEA_ID":22065,"compounds":"5alpha-ergosta-7,22-diene-3beta,5-diol => ergosterol + H2O"}
{"X":24923,"RHEA_ID":42611,"compounds":"a plastoquinone + (n+1) H(+)(in) + NADH <=> a plastoquinol + n H(+)(out) + NAD(+)"}
{"X":24924,"RHEA_ID":32655,"DIRECTION":"UN","MASTER_ID":32655,"ec":"1.1.1.318","metacyc":"RXN-12939","compounds":"a carboxylate + eugenol + NADP(+) = a coniferyl ester + NADPH"}
{"X":24925,"RHEA_ID":22068,"DIRECTION":"UN","MASTER_ID":22068,"ec":"1.1.1.383","compounds":"(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + H(+) + NADPH"}
{"X":24926,"RHEA_ID":22068,"DIRECTION":"UN","MASTER_ID":22068,"ec":"1.1.1.86","compounds":"(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + H(+) + NADPH"}
{"X":24927,"RHEA_ID":42615,"compounds":"a plastoquinone + (n+1) H(+)(in) + NADPH <=> a plastoquinol + n H(+)(out) + NADP(+)"}
{"X":24928,"RHEA_ID":22070,"compounds":"(2S)-2-acetolactate + H(+) + NADPH => (2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+)"}
{"X":24929,"RHEA_ID":32660,"DIRECTION":"LR","MASTER_ID":32659,"metacyc":"RXN-12961","compounds":"(6E)-8-hydroxygeraniol + 2 NADP(+) => (6E)-8-oxogeranial + 2 H(+) + 2 NADPH"}
{"X":24930,"RHEA_ID":32661,"compounds":"(6E)-8-oxogeranial + 2 H(+) + 2 NADPH => (6E)-8-hydroxygeraniol + 2 NADP(+)"}
{"X":24931,"RHEA_ID":22072,"DIRECTION":"UN","MASTER_ID":22072,"ec":"2.7.1.16","compounds":"ATP + L-ribulose = ADP + H(+) + L-ribulose 5-phosphate"}
{"X":24932,"RHEA_ID":22073,"DIRECTION":"LR","MASTER_ID":22072,"ecocyc":"RXN0-5116","metacyc":"RXN0-5116","compounds":"ATP + L-ribulose => ADP + H(+) + L-ribulose 5-phosphate"}
{"X":24933,"RHEA_ID":22074,"compounds":"ADP + H(+) + L-ribulose 5-phosphate => ATP + L-ribulose"}
{"X":24934,"RHEA_ID":32665,"compounds":"5-guanidino-3-methyl-2-oxopentanoate + H(+) + S-adenosyl-L-homocysteine => 5-guanidino-2-oxopentanoate + S-adenosyl-L-methionine"}
{"X":24935,"RHEA_ID":52607,"compounds":"3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-seryl-[protein] + ATP <=> 3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-6-O-phospho-alpha-D-mannosyl)-L-seryl-[protein] + ADP + H(+)"}
{"X":24936,"RHEA_ID":22081,"DIRECTION":"LR","MASTER_ID":22080,"metacyc":"1.14.13.61-RXN","compounds":"H(+) + NADH + O2 + quinolin-2-ol => H2O + NAD(+) + quinoline-2,8-diol"}
{"X":24937,"RHEA_ID":22082,"compounds":"H2O + NAD(+) + quinoline-2,8-diol => H(+) + NADH + O2 + quinolin-2-ol"}
{"X":24938,"RHEA_ID":32669,"compounds":"H(+) + hydrogen sulfide + methyl-coenzyme M => coenzyme M + methanethiol"}
{"X":24939,"RHEA_ID":42627,"compounds":"(Z)-3-ureidoacrylate + H(+) + H2O <=> (Z)-3-aminoacrylate + CO2 + NH4(+)"}
{"X":24940,"RHEA_ID":22085,"DIRECTION":"LR","MASTER_ID":22084,"ecocyc":"4.3.1.15-RXN","metacyc":"4.3.1.15-RXN","compounds":"(S)-2,3-diaminopropanoate + H(+) + H2O => 2 NH4(+) + pyruvate"}
{"X":24941,"RHEA_ID":22086,"compounds":"2 NH4(+) + pyruvate => (S)-2,3-diaminopropanoate + H(+) + H2O"}
{"X":24942,"RHEA_ID":22088,"DIRECTION":"UN","MASTER_ID":22088,"ec":"2.7.6.5","compounds":"ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate"}
{"X":24943,"RHEA_ID":32675,"DIRECTION":"UN","MASTER_ID":32675,"ec":"3.2.1.28","compounds":"alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose"}
{"X":24944,"RHEA_ID":22090,"compounds":"AMP + guanosine 3'-diphosphate 5'-triphosphate => ATP + GTP"}
{"X":24945,"RHEA_ID":32677,"compounds":"alpha-D-glucose + beta-D-glucose => alpha,alpha-trehalose + H2O"}
{"X":24946,"RHEA_ID":22092,"DIRECTION":"UN","MASTER_ID":22092,"ec":"1.3.7.3","compounds":"(3Z)-phycoerythrobilin + oxidized 2[4Fe-4S]-[ferredoxin] = 15,16-dihydrobiliverdin + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]"}
{"X":24947,"RHEA_ID":32679,"DIRECTION":"UN","MASTER_ID":32679,"ec":"3.1.7.11","compounds":"(2E)-geranyl diphosphate + H2O = diphosphate + geraniol"}
{"X":24948,"RHEA_ID":22094,"DIRECTION":"RL","MASTER_ID":22092,"metacyc":"1.3.7.3-RXN","compounds":"15,16-dihydrobiliverdin + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] => (3Z)-phycoerythrobilin + oxidized 2[4Fe-4S]-[ferredoxin]"}
{"X":24949,"RHEA_ID":32681,"compounds":"diphosphate + geraniol => (2E)-geranyl diphosphate + H2O"}
{"X":24950,"RHEA_ID":22096,"DIRECTION":"UN","MASTER_ID":22096,"ec":"2.7.7.8","compounds":"phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n)"}
{"X":24951,"RHEA_ID":32683,"DIRECTION":"UN","MASTER_ID":32683,"ec":"1.1.3.47","compounds":"5-hydroxymethylfurfural + 2 H2O + 3 O2 = 2,5-dicarboxyfuran + 2 H(+) + 3 H2O2"}
{"X":24952,"RHEA_ID":22098,"compounds":"a ribonucleoside 5'-diphosphate + RNA(n) => phosphate + RNA(n+1)"}
{"X":24953,"RHEA_ID":22100,"DIRECTION":"UN","MASTER_ID":22100,"ec":"3.5.5.6","metacyc":"3.5.5.6-RXN","compounds":"3,5-dibromo-4-hydroxybenzonitrile + 2 H2O = 3,5-dibromo-4-hydroxybenzoate + NH4(+)"}
{"X":24954,"RHEA_ID":32687,"DIRECTION":"UN","MASTER_ID":32687,"ec":"4.2.3.105","compounds":"(2E)-geranyl diphosphate = diphosphate + tricyclene"}
{"X":24955,"RHEA_ID":22102,"compounds":"3,5-dibromo-4-hydroxybenzoate + NH4(+) => 3,5-dibromo-4-hydroxybenzonitrile + 2 H2O"}
{"X":24956,"RHEA_ID":32689,"compounds":"diphosphate + tricyclene => (2E)-geranyl diphosphate"}
{"X":24957,"RHEA_ID":22104,"DIRECTION":"UN","MASTER_ID":22104,"ec":"2.6.1.80","compounds":"2-oxoglutarate + nicotianamine = 3''-deamino-3''-oxonicotianamine + L-glutamate"}
{"X":24958,"RHEA_ID":32691,"DIRECTION":"UN","MASTER_ID":32691,"ec":"4.2.3.106","compounds":"(2E)-geranyl diphosphate = (E)-beta-ocimene + diphosphate"}
{"X":24959,"RHEA_ID":22106,"compounds":"3''-deamino-3''-oxonicotianamine + L-glutamate => 2-oxoglutarate + nicotianamine"}
{"X":24960,"RHEA_ID":32693,"compounds":"(E)-beta-ocimene + diphosphate => (2E)-geranyl diphosphate"}
{"X":24961,"RHEA_ID":22108,"DIRECTION":"UN","MASTER_ID":22108,"ec":"4.3.1.19","compounds":"L-threonine = 2-oxobutanoate + NH4(+)"}
{"X":24962,"RHEA_ID":32695,"compounds":"(2E)-geranyl diphosphate = (-)-car-3-ene + diphosphate"}
{"X":24963,"RHEA_ID":22110,"compounds":"2-oxobutanoate + NH4(+) => L-threonine"}
{"X":24964,"RHEA_ID":32697,"compounds":"(-)-car-3-ene + diphosphate => (2E)-geranyl diphosphate"}
{"X":24965,"RHEA_ID":22112,"DIRECTION":"UN","MASTER_ID":22112,"ec":"2.5.1.118","metacyc":"RXN-15245","compounds":"isoxazolin-5-one + O-acetyl-L-serine = 3-(5-oxoisoxazolin-2-yl)-L-alanine + acetate + H(+)"}
{"X":24966,"RHEA_ID":32699,"DIRECTION":"UN","MASTER_ID":32699,"ec":"4.2.3.123","compounds":"(2E,6E)-farnesyl diphosphate = beta-sesquiphellandrene + diphosphate"}
{"X":24967,"RHEA_ID":22114,"compounds":"3-(5-oxoisoxazolin-2-yl)-L-alanine + acetate + H(+) => isoxazolin-5-one + O-acetyl-L-serine"}
{"X":24968,"RHEA_ID":32701,"compounds":"beta-sesquiphellandrene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":24969,"RHEA_ID":22116,"DIRECTION":"UN","MASTER_ID":22116,"ec":"2.4.1.191","compounds":"luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP-alpha-D-glucuronate = H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] 4'-O-beta-D-glucuronide + UDP"}
{"X":24970,"RHEA_ID":32703,"DIRECTION":"UN","MASTER_ID":32703,"ec":"4.2.1.133","compounds":"all-trans-geranylgeranyl diphosphate + H2O = 8-hydroxycopalyl diphosphate"}
{"X":24971,"RHEA_ID":22118,"compounds":"H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] 4'-O-beta-D-glucuronide + UDP => luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP-alpha-D-glucuronate"}
{"X":24972,"RHEA_ID":32705,"compounds":"8-hydroxycopalyl diphosphate => all-trans-geranylgeranyl diphosphate + H2O"}
{"X":24973,"RHEA_ID":22120,"DIRECTION":"UN","MASTER_ID":22120,"ec":"6.2.1.4","compounds":"CoA + GTP + succinate = GDP + phosphate + succinyl-CoA"}
{"X":24974,"RHEA_ID":22121,"compounds":"CoA + GTP + succinate => GDP + phosphate + succinyl-CoA"}
{"X":24975,"RHEA_ID":22122,"DIRECTION":"RL","MASTER_ID":22120,"reactome":"R-HSA-71775.3","compounds":"GDP + phosphate + succinyl-CoA => CoA + GTP + succinate"}
{"X":24976,"RHEA_ID":32709,"compounds":"(2R,4S)-bornyl diphosphate => (2E)-geranyl diphosphate"}
{"X":24977,"RHEA_ID":22124,"DIRECTION":"UN","MASTER_ID":22124,"ec":"3.1.1.80","compounds":"17-O-acetylajmaline + H2O = acetate + ajmaline + H(+)"}
{"X":24978,"RHEA_ID":32711,"DIRECTION":"UN","MASTER_ID":32711,"ec":"1.1.1.n12","compounds":"a (3R)-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH"}
{"X":24979,"RHEA_ID":22125,"DIRECTION":"LR","MASTER_ID":22124,"metacyc":"RXN-8652","compounds":"17-O-acetylajmaline + H2O => acetate + ajmaline + H(+)"}
{"X":24980,"RHEA_ID":22126,"compounds":"acetate + ajmaline + H(+) => 17-O-acetylajmaline + H2O"}
{"X":24981,"RHEA_ID":32714,"compounds":"a (3R)-hydroxyacyl-CoA + NAD(+) <=> a 3-oxoacyl-CoA + H(+) + NADH"}
{"X":24982,"RHEA_ID":32715,"DIRECTION":"UN","MASTER_ID":32715,"ec":"1.1.1.n5","compounds":"(2R,3S)-3-methylmalate + NAD(+) = 2-oxobutanoate + CO2 + NADH"}
{"X":24983,"RHEA_ID":22129,"DIRECTION":"LR","MASTER_ID":22128,"metacyc":"--BORNEOL-DEHYDROGENASE-RXN","compounds":"(1S,2R,4S)-borneol + NAD(+) => (1S,4S)-camphor + H(+) + NADH"}
{"X":24984,"RHEA_ID":22130,"compounds":"(1S,4S)-camphor + H(+) + NADH => (1S,2R,4S)-borneol + NAD(+)"}
{"X":24985,"RHEA_ID":42674,"compounds":"H2O + L-gamma-glutamyl-hercynylcysteine S-oxide => hercynine + L-gamma-glutamyl-L-cysteine + O2"}
{"X":24986,"RHEA_ID":22132,"DIRECTION":"UN","MASTER_ID":22132,"ec":"7.5.2.1","compounds":"ATP + D-maltose(out) + H2O = ADP + D-maltose(in) + H(+) + phosphate"}
{"X":24987,"RHEA_ID":22133,"DIRECTION":"LR","MASTER_ID":22132,"ecocyc":"ABC-16-RXN","metacyc":"ABC-16-RXN","compounds":"ATP + D-maltose(out) + H2O => ADP + D-maltose(in) + H(+) + phosphate"}
{"X":24988,"RHEA_ID":22134,"compounds":"ADP + D-maltose(in) + H(+) + phosphate => ATP + D-maltose(out) + H2O"}
{"X":24989,"RHEA_ID":22135,"compounds":"ATP + D-maltose(out) + H2O <=> ADP + D-maltose(in) + H(+) + phosphate"}
{"X":24990,"RHEA_ID":32723,"DIRECTION":"UN","MASTER_ID":32723,"ec":"1.14.14.42","compounds":"L-trihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-6-(methylsulfanyl)hexanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":24991,"RHEA_ID":22137,"DIRECTION":"LR","MASTER_ID":22136,"metacyc":"RXN-7677","compounds":"7(1)-hydroxychlorophyllide a + H(+) + NADPH + O2 => chlorophyllide b + 2 H2O + NADP(+)"}
{"X":24992,"RHEA_ID":22138,"compounds":"chlorophyllide b + 2 H2O + NADP(+) => 7(1)-hydroxychlorophyllide a + H(+) + NADPH + O2"}
{"X":24993,"RHEA_ID":42682,"compounds":"2 H2O + 2 hercynylselenocysteine => 2 hercynine + 2 L-selenocysteine + O2"}
{"X":24994,"RHEA_ID":32727,"DIRECTION":"UN","MASTER_ID":32727,"ec":"2.3.1.199","compounds":"a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA"}
{"X":24995,"RHEA_ID":22141,"DIRECTION":"LR","MASTER_ID":22140,"metacyc":"NUCLEOTIDASE-RXN","compounds":"a nucleoside 5'-phosphate + H2O => a nucleoside + phosphate"}
{"X":24996,"RHEA_ID":22142,"compounds":"a nucleoside + phosphate => a nucleoside 5'-phosphate + H2O"}
{"X":24997,"RHEA_ID":32731,"DIRECTION":"UN","MASTER_ID":32731,"ec":"3.1.1.79","compounds":"a diacylglycerol + H2O = a fatty acid + a monoacylglycerol + H(+)"}
{"X":24998,"RHEA_ID":22145,"compounds":"cis-aconitate + H2O => isocitrate"}
{"X":24999,"RHEA_ID":22146,"compounds":"isocitrate => cis-aconitate + H2O"}
{"X":25000,"RHEA_ID":32734,"compounds":"a diacylglycerol + H2O <=> a fatty acid + a monoacylglycerol + H(+)"}
{"X":25001,"RHEA_ID":22148,"DIRECTION":"UN","MASTER_ID":22148,"ec":"7.1.1.6","compounds":"a plastoquinol + 2 H(+)(in) + 2 oxidized [plastocyanin] = a plastoquinone + 4 H(+)(out) + 2 reduced [plastocyanin]"}
{"X":25002,"RHEA_ID":22149,"DIRECTION":"LR","MASTER_ID":22148,"metacyc":"PLASTOQUINOL--PLASTOCYANIN-REDUCTASE-RXN","compounds":"a plastoquinol + 2 H(+)(in) + 2 oxidized [plastocyanin] => a plastoquinone + 4 H(+)(out) + 2 reduced [plastocyanin]"}
{"X":25003,"RHEA_ID":22150,"compounds":"a plastoquinone + 4 H(+)(out) + 2 reduced [plastocyanin] => a plastoquinol + 2 H(+)(in) + 2 oxidized [plastocyanin]"}
{"X":25004,"RHEA_ID":32739,"DIRECTION":"UN","MASTER_ID":32739,"ec":"2.1.1.71","compounds":"1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine"}
{"X":25005,"RHEA_ID":22153,"DIRECTION":"LR","MASTER_ID":22152,"ecocyc":"RXN0-6373","metacyc":"RXN0-6373","compounds":"a ubiquinone + D-glucose => a ubiquinol + D-glucono-1,5-lactone"}
{"X":25006,"RHEA_ID":22153,"DIRECTION":"LR","MASTER_ID":22152,"ecocyc":"RXN0-6373","metacyc":"GLUCDEHYDROG-RXN","compounds":"a ubiquinone + D-glucose => a ubiquinol + D-glucono-1,5-lactone"}
{"X":25007,"RHEA_ID":22153,"DIRECTION":"LR","MASTER_ID":22152,"ecocyc":"GLUCDEHYDROG-RXN","metacyc":"RXN0-6373","compounds":"a ubiquinone + D-glucose => a ubiquinol + D-glucono-1,5-lactone"}
{"X":25008,"RHEA_ID":32743,"DIRECTION":"UN","MASTER_ID":32743,"ec":"2.5.1.134","compounds":"L-homocysteine + O-acetyl-L-serine = acetate + H(+) + L,L-cystathionine"}
{"X":25009,"RHEA_ID":22154,"compounds":"a ubiquinol + D-glucono-1,5-lactone => a ubiquinone + D-glucose"}
{"X":25010,"RHEA_ID":32745,"compounds":"acetate + H(+) + L,L-cystathionine => L-homocysteine + O-acetyl-L-serine"}
{"X":25011,"RHEA_ID":22156,"DIRECTION":"UN","MASTER_ID":22156,"ec":"3.6.1.42","compounds":"GDP + H2O = GMP + H(+) + phosphate"}
{"X":25012,"RHEA_ID":22157,"DIRECTION":"LR","MASTER_ID":22156,"ecocyc":"GUANOSINE-DIPHOSPHATASE-RXN","metacyc":"GUANOSINE-DIPHOSPHATASE-RXN","compounds":"GDP + H2O => GMP + H(+) + phosphate"}
{"X":25013,"RHEA_ID":22158,"compounds":"GMP + H(+) + phosphate => GDP + H2O"}
{"X":25014,"RHEA_ID":32749,"compounds":"ethanolamine(out) => ethanolamine(in)"}
{"X":25015,"RHEA_ID":22160,"DIRECTION":"UN","MASTER_ID":22160,"ec":"2.3.1.173","compounds":"4-coumaroyl-CoA + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside = a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] + CoA"}
{"X":25016,"RHEA_ID":22161,"compounds":"4-coumaroyl-CoA + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside => a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] + CoA"}
{"X":25017,"RHEA_ID":22162,"compounds":"a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] + CoA => 4-coumaroyl-CoA + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside"}
{"X":25018,"RHEA_ID":22163,"DIRECTION":"BI","MASTER_ID":22160,"metacyc":"2.3.1.173-RXN","compounds":"4-coumaroyl-CoA + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside <=> a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] + CoA"}
{"X":25019,"RHEA_ID":22164,"DIRECTION":"UN","MASTER_ID":22164,"ec":"2.4.1.88","compounds":"globoside Gb4Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = globoside Forssman (d18:1(4E)) + H(+) + UDP"}
{"X":25020,"RHEA_ID":32753,"DIRECTION":"RL","MASTER_ID":32751,"reactome":"R-HSA-444433.1","compounds":"choline(in) => choline(out)"}
{"X":25021,"RHEA_ID":22166,"compounds":"globoside Forssman (d18:1(4E)) + H(+) + UDP => globoside Gb4Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine"}
{"X":25022,"RHEA_ID":32753,"DIRECTION":"RL","MASTER_ID":32751,"reactome":"R-HSA-6797956.1","compounds":"choline(in) => choline(out)"}
{"X":25023,"RHEA_ID":22168,"DIRECTION":"UN","MASTER_ID":22168,"ec":"5.1.3.2","compounds":"UDP-alpha-D-glucose = UDP-alpha-D-galactose"}
{"X":25024,"RHEA_ID":22169,"compounds":"UDP-alpha-D-glucose => UDP-alpha-D-galactose"}
{"X":25025,"RHEA_ID":22170,"compounds":"UDP-alpha-D-galactose => UDP-alpha-D-glucose"}
{"X":25026,"RHEA_ID":32757,"compounds":"apigenin + CO2 + H(+) + H2O + succinate => (S)-naringenin + 2-oxoglutarate + O2"}
{"X":25027,"RHEA_ID":22172,"DIRECTION":"UN","MASTER_ID":22172,"ec":"2.4.1.14","compounds":"beta-D-fructose 6-phosphate + UDP-alpha-D-glucose = H(+) + sucrose 6(F)-phosphate + UDP"}
{"X":25028,"RHEA_ID":32759,"DIRECTION":"UN","MASTER_ID":32759,"ec":"5.4.99.58","compounds":"L-lysine = (3R)-3-methyl-D-ornithine"}
{"X":25029,"RHEA_ID":22174,"compounds":"H(+) + sucrose 6(F)-phosphate + UDP => beta-D-fructose 6-phosphate + UDP-alpha-D-glucose"}
{"X":25030,"RHEA_ID":32761,"compounds":"(3R)-3-methyl-D-ornithine => L-lysine"}
{"X":25031,"RHEA_ID":22176,"DIRECTION":"UN","MASTER_ID":22176,"ec":"1.14.14.94","compounds":"leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":25032,"RHEA_ID":32763,"compounds":"(3R)-3-methyl-D-ornithine + L-lysine = (3R)-3-methyl-D-ornithyl-N(6)-L-lysine + H2O"}
{"X":25033,"RHEA_ID":22178,"compounds":"20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":25034,"RHEA_ID":32765,"compounds":"(3R)-3-methyl-D-ornithyl-N(6)-L-lysine + H2O => (3R)-3-methyl-D-ornithine + L-lysine"}
{"X":25035,"RHEA_ID":22180,"compounds":"(S)-norreticuline + S-adenosyl-L-methionine = (S)-norcodamine + H(+) + S-adenosyl-L-homocysteine"}
{"X":25036,"RHEA_ID":32767,"DIRECTION":"UN","MASTER_ID":32767,"ec":"2.1.1.225","compounds":"cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Pro) + H(+) + S-adenosyl-L-homocysteine"}
{"X":25037,"RHEA_ID":22182,"compounds":"(S)-norcodamine + H(+) + S-adenosyl-L-homocysteine => (S)-norreticuline + S-adenosyl-L-methionine"}
{"X":25038,"RHEA_ID":22183,"compounds":"(S)-norreticuline + S-adenosyl-L-methionine <=> (S)-norcodamine + H(+) + S-adenosyl-L-homocysteine"}
{"X":25039,"RHEA_ID":22184,"DIRECTION":"UN","MASTER_ID":22184,"ec":"1.10.1.1","metacyc":"1.10.1.1-RXN","compounds":"(+-)-trans-acenaphthene-1,2-diol + 2 NADP(+) = acenaphthene-1,2-dione + 2 H(+) + 2 NADPH"}
{"X":25040,"RHEA_ID":32771,"compounds":"2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate = 2,6-dioxo-6-phenylhexa-3-enoate"}
{"X":25041,"RHEA_ID":22186,"compounds":"acenaphthene-1,2-dione + 2 H(+) + 2 NADPH => (+-)-trans-acenaphthene-1,2-diol + 2 NADP(+)"}
{"X":25042,"RHEA_ID":32773,"compounds":"2,6-dioxo-6-phenylhexa-3-enoate => 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate"}
{"X":25043,"RHEA_ID":22188,"DIRECTION":"UN","MASTER_ID":22188,"ec":"3.8.1.10","compounds":"an (R)-2-haloacid + H2O = a (2S)-2-hydroxycarboxylate + a halide anion + H(+)"}
{"X":25044,"RHEA_ID":32775,"compounds":"(2-aminoethyl)phosphonate(out) + ATP + H2O = (2-aminoethyl)phosphonate(in) + ADP + H(+) + phosphate"}
{"X":25045,"RHEA_ID":22189,"DIRECTION":"LR","MASTER_ID":22188,"metacyc":"RXN-6264","compounds":"an (R)-2-haloacid + H2O => a (2S)-2-hydroxycarboxylate + a halide anion + H(+)"}
{"X":25046,"RHEA_ID":22190,"compounds":"a (2S)-2-hydroxycarboxylate + a halide anion + H(+) => an (R)-2-haloacid + H2O"}
{"X":25047,"RHEA_ID":22192,"DIRECTION":"UN","MASTER_ID":22192,"ec":"2.1.2.3","compounds":"(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide"}
{"X":25048,"RHEA_ID":22193,"DIRECTION":"LR","MASTER_ID":22192,"reactome":"R-HSA-73798.2","compounds":"(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide => (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide"}
{"X":25049,"RHEA_ID":22194,"compounds":"(6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide => (6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide"}
{"X":25050,"RHEA_ID":32782,"compounds":"ATP + Co(2+)(out) + H2O <=> ADP + Co(2+)(in) + H(+) + phosphate"}
{"X":25051,"RHEA_ID":32783,"compounds":"ATP + betaine(out) + H2O = ADP + betaine(in) + H(+) + phosphate"}
{"X":25052,"RHEA_ID":22197,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + AH2 + O2 => (6Z,9Z,12Z)-octadecatrienoyl-CoA + A + 2 H2O"}
{"X":25053,"RHEA_ID":22198,"compounds":"(6Z,9Z,12Z)-octadecatrienoyl-CoA + A + 2 H2O => (9Z,12Z)-octadecadienoyl-CoA + AH2 + O2"}
{"X":25054,"RHEA_ID":32787,"compounds":"ATP + H2O + L-ectoine(out) = ADP + H(+) + L-ectoine(in) + phosphate"}
{"X":25055,"RHEA_ID":22201,"DIRECTION":"LR","MASTER_ID":22200,"metacyc":"2.1.1.145-RXN","compounds":"S-adenosyl-L-methionine + trans-aconitate => (E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine"}
{"X":25056,"RHEA_ID":22202,"compounds":"(E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + trans-aconitate"}
{"X":25057,"RHEA_ID":32790,"compounds":"ATP + H2O + L-ectoine(out) <=> ADP + H(+) + L-ectoine(in) + phosphate"}
{"X":25058,"RHEA_ID":32791,"compounds":"L-ectoine(in) = L-ectoine(out)"}
{"X":25059,"RHEA_ID":22205,"DIRECTION":"LR","MASTER_ID":22204,"metacyc":"1.14.13.63-RXN","compounds":"3-hydroxyphenylacetate + H(+) + NADPH + O2 => H2O + homogentisate + NADP(+)"}
{"X":25060,"RHEA_ID":22206,"compounds":"H2O + homogentisate + NADP(+) => 3-hydroxyphenylacetate + H(+) + NADPH + O2"}
{"X":25061,"RHEA_ID":32794,"compounds":"L-ectoine(in) <=> L-ectoine(out)"}
{"X":25062,"RHEA_ID":32795,"compounds":"ATP + H2O + L-cysteine(out) = ADP + H(+) + L-cysteine(in) + phosphate"}
{"X":25063,"RHEA_ID":22209,"DIRECTION":"LR","MASTER_ID":22208,"metacyc":"1.14.13.63-RXN","compounds":"3-hydroxyphenylacetate + H(+) + NADH + O2 => H2O + homogentisate + NAD(+)"}
{"X":25064,"RHEA_ID":22210,"compounds":"H2O + homogentisate + NAD(+) => 3-hydroxyphenylacetate + H(+) + NADH + O2"}
{"X":25065,"RHEA_ID":32798,"compounds":"ATP + H2O + L-cysteine(out) <=> ADP + H(+) + L-cysteine(in) + phosphate"}
{"X":25066,"RHEA_ID":32799,"compounds":"urea(in) = urea(out)"}
{"X":25067,"RHEA_ID":22213,"compounds":"(2R,3R)-tartrate => (2R,3S)-tartrate"}
{"X":25068,"RHEA_ID":22214,"compounds":"(2R,3S)-tartrate => (2R,3R)-tartrate"}
{"X":25069,"RHEA_ID":32801,"DIRECTION":"RL","MASTER_ID":32799,"reactome":"R-HSA-507873.3","compounds":"urea(out) => urea(in)"}
{"X":25070,"RHEA_ID":22216,"DIRECTION":"UN","MASTER_ID":22216,"ec":"1.13.11.22","compounds":"(E)-caffeate + O2 = 3-(2-carboxyethenyl)-cis,cis-muconate + 2 H(+)"}
{"X":25071,"RHEA_ID":32803,"compounds":"ATP + H2O + urea(out) = ADP + H(+) + phosphate + urea(in)"}
{"X":25072,"RHEA_ID":22218,"compounds":"3-(2-carboxyethenyl)-cis,cis-muconate + 2 H(+) => (E)-caffeate + O2"}
{"X":25073,"RHEA_ID":32805,"compounds":"ADP + H(+) + phosphate + urea(in) => ATP + H2O + urea(out)"}
{"X":25074,"RHEA_ID":22220,"DIRECTION":"UN","MASTER_ID":22220,"ec":"4.2.3.19","compounds":"ent-copalyl diphosphate = diphosphate + ent-kaur-16-ene"}
{"X":25075,"RHEA_ID":32807,"compounds":"thiosulfate(in) = thiosulfate(out)"}
{"X":25076,"RHEA_ID":22222,"compounds":"diphosphate + ent-kaur-16-ene => ent-copalyl diphosphate"}
{"X":25077,"RHEA_ID":32809,"compounds":"thiosulfate(out) => thiosulfate(in)"}
{"X":25078,"RHEA_ID":22224,"DIRECTION":"UN","MASTER_ID":22224,"ec":"2.3.1.159","compounds":"3 H(+) + 3 malonyl-CoA + N-methylanthraniloyl-CoA = 1,3-dihydroxy-N-methylacridone + 3 CO2 + 4 CoA + H2O"}
{"X":25079,"RHEA_ID":32811,"compounds":"benzoate(in) = benzoate(out)"}
{"X":25080,"RHEA_ID":22226,"compounds":"1,3-dihydroxy-N-methylacridone + 3 CO2 + 4 CoA + H2O => 3 H(+) + 3 malonyl-CoA + N-methylanthraniloyl-CoA"}
{"X":25081,"RHEA_ID":32813,"compounds":"benzoate(out) => benzoate(in)"}
{"X":25082,"RHEA_ID":22228,"compounds":"H(+) + NADH + presqualene diphosphate = diphosphate + NAD(+) + squalene"}
{"X":25083,"RHEA_ID":32815,"compounds":"Hg(2+)(in) = Hg(2+)(out)"}
{"X":25084,"RHEA_ID":22230,"compounds":"diphosphate + NAD(+) + squalene => H(+) + NADH + presqualene diphosphate"}
{"X":25085,"RHEA_ID":32817,"compounds":"Hg(2+)(out) => Hg(2+)(in)"}
{"X":25086,"RHEA_ID":22232,"DIRECTION":"UN","MASTER_ID":22232,"ec":"1.3.1.96","compounds":"H(+) + NADPH + presqualene diphosphate = diphosphate + NADP(+) + squalene"}
{"X":25087,"RHEA_ID":32819,"compounds":"chromate(in) = chromate(out)"}
{"X":25088,"RHEA_ID":22234,"compounds":"diphosphate + NADP(+) + squalene => H(+) + NADPH + presqualene diphosphate"}
{"X":25089,"RHEA_ID":32821,"compounds":"chromate(out) => chromate(in)"}
{"X":25090,"RHEA_ID":22236,"DIRECTION":"UN","MASTER_ID":22236,"ec":"3.1.3.68","compounds":"2-deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate"}
{"X":25091,"RHEA_ID":32823,"compounds":"phosphate(in) = phosphate(out)"}
{"X":25092,"RHEA_ID":22238,"compounds":"2-deoxy-D-glucose + phosphate => 2-deoxy-D-glucose 6-phosphate + H2O"}
{"X":25093,"RHEA_ID":32825,"compounds":"phosphate(out) => phosphate(in)"}
{"X":25094,"RHEA_ID":22240,"compounds":"H2O + methylenediurea = N-(carboxyaminomethyl)urea + NH4(+)"}
{"X":25095,"RHEA_ID":32827,"compounds":"ATP + H2O + methionine(out) = ADP + H(+) + methionine(in) + phosphate"}
{"X":25096,"RHEA_ID":22242,"compounds":"N-(carboxyaminomethyl)urea + NH4(+) => H2O + methylenediurea"}
{"X":25097,"RHEA_ID":32829,"compounds":"ADP + H(+) + methionine(in) + phosphate => ATP + H2O + methionine(out)"}
{"X":25098,"RHEA_ID":22244,"DIRECTION":"UN","MASTER_ID":22244,"ec":"2.4.2.56","metacyc":"RXN-14702","compounds":"kaempferol + UDP-alpha-D-xylose = H(+) + kaempferol 3-O-beta-D-xyloside + UDP"}
{"X":25099,"RHEA_ID":32831,"compounds":"cob(III)alamin(in) = cob(III)alamin(out)"}
{"X":25100,"RHEA_ID":22246,"compounds":"H(+) + kaempferol 3-O-beta-D-xyloside + UDP => kaempferol + UDP-alpha-D-xylose"}
{"X":25101,"RHEA_ID":32833,"DIRECTION":"RL","MASTER_ID":32831,"reactome":"R-HSA-3000238.1","compounds":"cob(III)alamin(out) => cob(III)alamin(in)"}
{"X":25102,"RHEA_ID":22248,"DIRECTION":"UN","MASTER_ID":22248,"ec":"1.3.1.18","metacyc":"1.3.1.18-RXN","compounds":"7,8-dihydro-7,8-dihydroxykynurenate + NAD(+) = 7,8-dihydroxykynurenate + H(+) + NADH"}
{"X":25103,"RHEA_ID":32835,"compounds":"4-(trimethylamino)butanoate(in) = 4-(trimethylamino)butanoate(out)"}
{"X":25104,"RHEA_ID":22250,"compounds":"7,8-dihydroxykynurenate + H(+) + NADH => 7,8-dihydro-7,8-dihydroxykynurenate + NAD(+)"}
{"X":25105,"RHEA_ID":32837,"compounds":"4-(trimethylamino)butanoate(out) => 4-(trimethylamino)butanoate(in)"}
{"X":25106,"RHEA_ID":22252,"DIRECTION":"UN","MASTER_ID":22252,"ec":"2.4.1.79","compounds":"globoside Gb3Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = globoside Gb4Cer (d18:1(4E)) + H(+) + UDP"}
{"X":25107,"RHEA_ID":32843,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycerol = a 1-acyl-sn-glycero-3-phosphocholine + a triacyl-sn-glycerol"}
{"X":25108,"RHEA_ID":22254,"compounds":"globoside Gb4Cer (d18:1(4E)) + H(+) + UDP => globoside Gb3Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine"}
{"X":25109,"RHEA_ID":32845,"compounds":"a 1-acyl-sn-glycero-3-phosphocholine + a triacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycerol"}
{"X":25110,"RHEA_ID":22256,"DIRECTION":"UN","MASTER_ID":22256,"ec":"1.1.1.36","compounds":"a (3R)-hydroxyacyl-CoA + NADP(+) = a 3-oxoacyl-CoA + H(+) + NADPH"}
{"X":25111,"RHEA_ID":22257,"compounds":"a (3R)-hydroxyacyl-CoA + NADP(+) => a 3-oxoacyl-CoA + H(+) + NADPH"}
{"X":25112,"RHEA_ID":22258,"compounds":"a 3-oxoacyl-CoA + H(+) + NADPH => a (3R)-hydroxyacyl-CoA + NADP(+)"}
{"X":25113,"RHEA_ID":22260,"DIRECTION":"UN","MASTER_ID":22260,"ec":"3.1.1.38","compounds":"H2O + triacetate lactone = H(+) + triacetate"}
{"X":25114,"RHEA_ID":32851,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol = a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine"}
{"X":25115,"RHEA_ID":22262,"compounds":"H(+) + triacetate => H2O + triacetate lactone"}
{"X":25116,"RHEA_ID":32853,"compounds":"a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol"}
{"X":25117,"RHEA_ID":22268,"DIRECTION":"UN","MASTER_ID":22268,"ec":"2.7.1.72","compounds":"ATP + streptomycin = ADP + H(+) + streptomycin 6-phosphate"}
{"X":25118,"RHEA_ID":32855,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol = a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine"}
{"X":25119,"RHEA_ID":22270,"compounds":"ADP + H(+) + streptomycin 6-phosphate => ATP + streptomycin"}
{"X":25120,"RHEA_ID":32857,"compounds":"a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol"}
{"X":25121,"RHEA_ID":22272,"DIRECTION":"UN","MASTER_ID":22272,"ec":"1.14.14.121","compounds":"(20S)-protopanaxadiol + O2 + reduced [NADPH--hemoprotein reductase] = (20S)-protopanaxatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":25122,"RHEA_ID":32859,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol = a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine"}
{"X":25123,"RHEA_ID":22274,"compounds":"(20S)-protopanaxatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (20S)-protopanaxadiol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":25124,"RHEA_ID":32861,"compounds":"a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol"}
{"X":25125,"RHEA_ID":22276,"DIRECTION":"UN","MASTER_ID":22276,"ec":"1.2.1.23","metacyc":"2-OXOALDEHYDE-DEHYDROGENASE-NAD%2B-RXN","compounds":"2-oxoaldehyde + H2O + NAD(+) = a 2-oxocarboxylate + 2 H(+) + NADH"}
{"X":25126,"RHEA_ID":32863,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycerol = a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine"}
{"X":25127,"RHEA_ID":22278,"compounds":"a 2-oxocarboxylate + 2 H(+) + NADH => 2-oxoaldehyde + H2O + NAD(+)"}
{"X":25128,"RHEA_ID":22280,"DIRECTION":"UN","MASTER_ID":22280,"ec":"2.1.1.38","compounds":"O-demethylpuromycin + S-adenosyl-L-methionine = H(+) + puromycin + S-adenosyl-L-homocysteine"}
{"X":25129,"RHEA_ID":22281,"DIRECTION":"LR","MASTER_ID":22280,"metacyc":"2.1.1.38-RXN","compounds":"O-demethylpuromycin + S-adenosyl-L-methionine => H(+) + puromycin + S-adenosyl-L-homocysteine"}
{"X":25130,"RHEA_ID":32868,"compounds":"myo-inositol(out) => myo-inositol(in)"}
{"X":25131,"RHEA_ID":32869,"compounds":"myo-inositol(in) => myo-inositol(out)"}
{"X":25132,"RHEA_ID":22284,"DIRECTION":"UN","MASTER_ID":22284,"ec":"3.5.1.53","compounds":"2 H(+) + H2O + N-carbamoylputrescine = CO2 + NH4(+) + putrescine"}
{"X":25133,"RHEA_ID":22285,"DIRECTION":"LR","MASTER_ID":22284,"metacyc":"N-CARBAMOYLPUTRESCINE-AMIDASE-RXN","compounds":"2 H(+) + H2O + N-carbamoylputrescine => CO2 + NH4(+) + putrescine"}
{"X":25134,"RHEA_ID":32872,"compounds":"a 2-acylglycerol + H2O => a carboxylate + glycerol + H(+)"}
{"X":25135,"RHEA_ID":22288,"DIRECTION":"UN","MASTER_ID":22288,"ec":"3.2.1.123","compounds":"an oligoglycosyl-(1->4)-glucosyl-(1<->1)-ceramide + H2O = an oligoglycosyl-(1->4)-beta-D-glucose + N-acyl-sphingoid base"}
{"X":25136,"RHEA_ID":22289,"DIRECTION":"LR","MASTER_ID":22288,"metacyc":"ENDOGLYCOSYLCERAMIDASE-RXN","compounds":"an oligoglycosyl-(1->4)-glucosyl-(1<->1)-ceramide + H2O => an oligoglycosyl-(1->4)-beta-D-glucose + N-acyl-sphingoid base"}
{"X":25137,"RHEA_ID":32876,"compounds":"a 1-acyl-sn-glycerol + H2O => a fatty acid + glycerol + H(+)"}
{"X":25138,"RHEA_ID":22292,"DIRECTION":"UN","MASTER_ID":22292,"ec":"2.3.1.177","compounds":"benzoyl-CoA + 3 H(+) + 3 malonyl-CoA = biphenyl-3,5-diol + 4 CO2 + 4 CoA"}
{"X":25139,"RHEA_ID":22293,"DIRECTION":"LR","MASTER_ID":22292,"metacyc":"2.3.1.177-RXN","compounds":"benzoyl-CoA + 3 H(+) + 3 malonyl-CoA => biphenyl-3,5-diol + 4 CO2 + 4 CoA"}
{"X":25140,"RHEA_ID":32880,"DIRECTION":"LR","MASTER_ID":32879,"metacyc":"R542-RXN","compounds":"(1R,4R,5R)-5-hydroxycamphor + NAD(+) => (1R,4R)-bornane-2,5-dione + H(+) + NADH"}
{"X":25141,"RHEA_ID":32881,"compounds":"(1R,4R)-bornane-2,5-dione + H(+) + NADH => (1R,4R,5R)-5-hydroxycamphor + NAD(+)"}
{"X":25142,"RHEA_ID":22296,"compounds":"2 all-trans-geranylgeranyl diphosphate = (1R,2R,3R)-prephytoene diphosphate + diphosphate"}
{"X":25143,"RHEA_ID":22297,"DIRECTION":"LR","MASTER_ID":22296,"metacyc":"2.5.1.32-RXN","compounds":"2 all-trans-geranylgeranyl diphosphate => (1R,2R,3R)-prephytoene diphosphate + diphosphate"}
{"X":25144,"RHEA_ID":22298,"compounds":"(1R,2R,3R)-prephytoene diphosphate + diphosphate => 2 all-trans-geranylgeranyl diphosphate"}
{"X":25145,"RHEA_ID":32885,"DIRECTION":"RL","MASTER_ID":32883,"metacyc":"RXN-8053","compounds":"(+)-artemisinic aldehyde + H(+) + NADPH => (11R)-dihydroartemisinic aldehyde + NADP(+)"}
{"X":25146,"RHEA_ID":22300,"DIRECTION":"UN","MASTER_ID":22300,"ec":"2.4.1.91","compounds":"a flavonol + UDP-alpha-D-glucose = a flavonol 3-O-beta-D-glucoside + H(+) + UDP"}
{"X":25147,"RHEA_ID":22301,"DIRECTION":"LR","MASTER_ID":22300,"metacyc":"FLAVONOL-3-O-GLUCOSYLTRANSFERASE-RXN","compounds":"a flavonol + UDP-alpha-D-glucose => a flavonol 3-O-beta-D-glucoside + H(+) + UDP"}
{"X":25148,"RHEA_ID":22302,"compounds":"a flavonol 3-O-beta-D-glucoside + H(+) + UDP => a flavonol + UDP-alpha-D-glucose"}
{"X":25149,"RHEA_ID":32889,"compounds":"2 all-trans-retinal => all-trans-beta-carotene + O2"}
{"X":25150,"RHEA_ID":22304,"DIRECTION":"UN","MASTER_ID":22304,"ec":"1.1.99.11","compounds":"A + D-fructose = 5-dehydro-D-fructose + AH2"}
{"X":25151,"RHEA_ID":22305,"compounds":"A + D-fructose => 5-dehydro-D-fructose + AH2"}
{"X":25152,"RHEA_ID":32892,"DIRECTION":"LR","MASTER_ID":32891,"metacyc":"RXN-12972","compounds":"(1S,5S)-alpha-pinene + H(+) + NADH + O2 => alpha-pinene oxide + H2O + NAD(+)"}
{"X":25153,"RHEA_ID":32893,"compounds":"alpha-pinene oxide + H2O + NAD(+) => (1S,5S)-alpha-pinene + H(+) + NADH + O2"}
{"X":25154,"RHEA_ID":22308,"DIRECTION":"UN","MASTER_ID":22308,"ec":"1.1.3.41","compounds":"O2 + xylitol = D-xylose + H2O2"}
{"X":25155,"RHEA_ID":22309,"DIRECTION":"LR","MASTER_ID":22308,"metacyc":"1.1.3.41-RXN","compounds":"O2 + xylitol => D-xylose + H2O2"}
{"X":25156,"RHEA_ID":32896,"DIRECTION":"LR","MASTER_ID":32895,"metacyc":"RXN-13133","compounds":"1,8-cineole + O2 + reduced [NADPH--hemoprotein reductase] => 2-exo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":25157,"RHEA_ID":32897,"compounds":"2-exo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 1,8-cineole + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":25158,"RHEA_ID":22312,"DIRECTION":"UN","MASTER_ID":22312,"ec":"2.7.1.100","compounds":"ATP + S-methyl-5-thio-D-ribose = ADP + H(+) + S-methyl-5-thio-alpha-D-ribose 1-phosphate"}
{"X":25159,"RHEA_ID":22313,"DIRECTION":"LR","MASTER_ID":22312,"metacyc":"5-METHYLTHIORIBOSE-KINASE-RXN","compounds":"ATP + S-methyl-5-thio-D-ribose => ADP + H(+) + S-methyl-5-thio-alpha-D-ribose 1-phosphate"}
{"X":25160,"RHEA_ID":22314,"compounds":"ADP + H(+) + S-methyl-5-thio-alpha-D-ribose 1-phosphate => ATP + S-methyl-5-thio-D-ribose"}
{"X":25161,"RHEA_ID":32901,"compounds":"2-endo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [flavodoxin] => 1,8-cineole + O2 + reduced [flavodoxin]"}
{"X":25162,"RHEA_ID":22316,"DIRECTION":"UN","MASTER_ID":22316,"ec":"2.4.1.158","compounds":"13-hydroxydocosanoate + UDP-alpha-D-glucose = 13-(beta-D-glucosyloxy)docosanoate + H(+) + UDP"}
{"X":25163,"RHEA_ID":22317,"DIRECTION":"LR","MASTER_ID":22316,"metacyc":"HYDROXYDOCOSANOATE-TRANS-RXN","compounds":"13-hydroxydocosanoate + UDP-alpha-D-glucose => 13-(beta-D-glucosyloxy)docosanoate + H(+) + UDP"}
{"X":25164,"RHEA_ID":32904,"DIRECTION":"LR","MASTER_ID":32903,"metacyc":"RXN-9829","compounds":"calciol + O2 + reduced [NADPH--hemoprotein reductase] => calcidiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":25165,"RHEA_ID":32905,"compounds":"calcidiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => calciol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":25166,"RHEA_ID":22320,"DIRECTION":"UN","MASTER_ID":22320,"ec":"2.4.1.139","metacyc":"MALTOSE-SYNTHASE-RXN","compounds":"2 alpha-D-glucose 1-phosphate + H2O = D-maltose + 2 phosphate"}
{"X":25167,"RHEA_ID":22321,"compounds":"2 alpha-D-glucose 1-phosphate + H2O => D-maltose + 2 phosphate"}
{"X":25168,"RHEA_ID":32908,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + 2 H2O => 2 a carboxylate + 2 H(+) + sn-glycerol 3-phosphocholine"}
{"X":25169,"RHEA_ID":32909,"compounds":"2 a carboxylate + 2 H(+) + sn-glycerol 3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + 2 H2O"}
{"X":25170,"RHEA_ID":22324,"DIRECTION":"UN","MASTER_ID":22324,"ec":"3.3.2.6","compounds":"H2O + leukotriene A4 = leukotriene B4"}
{"X":25171,"RHEA_ID":22325,"DIRECTION":"LR","MASTER_ID":22324,"macie":"M0166","metacyc":"LEUKOTRIENE-A4-HYDROLASE-RXN","reactome":"R-HSA-266072.1","compounds":"H2O + leukotriene A4 => leukotriene B4"}
{"X":25172,"RHEA_ID":22326,"compounds":"leukotriene B4 => H2O + leukotriene A4"}
{"X":25173,"RHEA_ID":22328,"DIRECTION":"UN","MASTER_ID":22328,"ec":"2.5.1.3","compounds":"4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate"}
{"X":25174,"RHEA_ID":22329,"DIRECTION":"LR","MASTER_ID":22328,"ecocyc":"THI-P-SYN-RXN","metacyc":"THI-P-SYN-RXN","compounds":"4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) => diphosphate + thiamine phosphate"}
{"X":25175,"RHEA_ID":32916,"compounds":"sn-glycero-3-phospho-1D-myo-inositol(out) => sn-glycero-3-phospho-1D-myo-inositol(in)"}
{"X":25176,"RHEA_ID":32917,"compounds":"sn-glycero-3-phospho-1D-myo-inositol(in) => sn-glycero-3-phospho-1D-myo-inositol(out)"}
{"X":25177,"RHEA_ID":22332,"DIRECTION":"UN","MASTER_ID":22332,"ec":"4.2.1.35","compounds":"(3R)-citramalate = 2-methylmaleate + H2O"}
{"X":25178,"RHEA_ID":22333,"DIRECTION":"LR","MASTER_ID":22332,"metacyc":"R-2-METHYLMALATE-DEHYDRATASE-RXN","compounds":"(3R)-citramalate => 2-methylmaleate + H2O"}
{"X":25179,"RHEA_ID":32924,"compounds":"H2O + sn-glycero-3-phospho-(1'-sn-glycerol) => glycerol + H(+) + sn-glycerol 3-phosphate"}
{"X":25180,"RHEA_ID":32925,"compounds":"glycerol + H(+) + sn-glycerol 3-phosphate => H2O + sn-glycero-3-phospho-(1'-sn-glycerol)"}
{"X":25181,"RHEA_ID":22336,"DIRECTION":"UN","MASTER_ID":22336,"ec":"2.1.1.5","compounds":"betaine + L-homocysteine = L-methionine + N,N-dimethylglycine"}
{"X":25182,"RHEA_ID":22337,"DIRECTION":"LR","MASTER_ID":22336,"metacyc":"2.1.1.5-RXN","compounds":"betaine + L-homocysteine => L-methionine + N,N-dimethylglycine"}
{"X":25183,"RHEA_ID":32928,"compounds":"1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => a 1,2-diacyl-sn-glycerol + H(+) + sn-glycerol 3-phosphate"}
{"X":25184,"RHEA_ID":32929,"compounds":"a 1,2-diacyl-sn-glycerol + H(+) + sn-glycerol 3-phosphate => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O"}
{"X":25185,"RHEA_ID":22340,"DIRECTION":"UN","MASTER_ID":22340,"ec":"1.1.1.97","compounds":"3-hydroxybenzyl alcohol + NADP(+) = 3-hydroxybenzaldehyde + H(+) + NADPH"}
{"X":25186,"RHEA_ID":22341,"DIRECTION":"LR","MASTER_ID":22340,"metacyc":"1.1.1.97-RXN","compounds":"3-hydroxybenzyl alcohol + NADP(+) => 3-hydroxybenzaldehyde + H(+) + NADPH"}
{"X":25187,"RHEA_ID":22342,"compounds":"3-hydroxybenzaldehyde + H(+) + NADPH => 3-hydroxybenzyl alcohol + NADP(+)"}
{"X":25188,"RHEA_ID":42886,"compounds":"(R)-3-phosphomevalonate + ADP + H(+) => (R)-mevalonate + ATP"}
{"X":25189,"RHEA_ID":22344,"DIRECTION":"UN","MASTER_ID":22344,"ec":"2.3.1.140","compounds":"(2R)-3-(3,4-dihydroxyphenyl)lactate + caffeoyl-CoA = (R)-rosmarinate + CoA"}
{"X":25190,"RHEA_ID":22345,"DIRECTION":"LR","MASTER_ID":22344,"metacyc":"ROSMARINATE-SYNTHASE-RXN","compounds":"(2R)-3-(3,4-dihydroxyphenyl)lactate + caffeoyl-CoA => (R)-rosmarinate + CoA"}
{"X":25191,"RHEA_ID":22346,"compounds":"(R)-rosmarinate + CoA => (2R)-3-(3,4-dihydroxyphenyl)lactate + caffeoyl-CoA"}
{"X":25192,"RHEA_ID":42890,"compounds":"(R)-3,5-bisphosphomevalonate + ADP + H(+) => (R)-3-phosphomevalonate + ATP"}
{"X":25193,"RHEA_ID":22348,"DIRECTION":"UN","MASTER_ID":22348,"ec":"3.5.4.8","compounds":"4-aminoimidazole + H(+) + H2O = imidazol-4-one + NH4(+)"}
{"X":25194,"RHEA_ID":22349,"DIRECTION":"LR","MASTER_ID":22348,"metacyc":"R13-RXN","compounds":"4-aminoimidazole + H(+) + H2O => imidazol-4-one + NH4(+)"}
{"X":25195,"RHEA_ID":22350,"compounds":"imidazol-4-one + NH4(+) => 4-aminoimidazole + H(+) + H2O"}
{"X":25196,"RHEA_ID":22352,"DIRECTION":"UN","MASTER_ID":22352,"ec":"4.1.1.18","compounds":"H(+) + L-lysine = cadaverine + CO2"}
{"X":25197,"RHEA_ID":22353,"DIRECTION":"LR","MASTER_ID":22352,"ecocyc":"LYSDECARBOX-RXN","metacyc":"LYSDECARBOX-RXN","compounds":"H(+) + L-lysine => cadaverine + CO2"}
{"X":25198,"RHEA_ID":22354,"compounds":"cadaverine + CO2 => H(+) + L-lysine"}
{"X":25199,"RHEA_ID":32945,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+) => a 1,2-diacyl-sn-glycerol + CDP-ethanolamine"}
{"X":25200,"RHEA_ID":22356,"DIRECTION":"UN","MASTER_ID":22356,"ec":"4.1.1.38","compounds":"diphosphate + oxaloacetate = CO2 + phosphate + phosphoenolpyruvate"}
{"X":25201,"RHEA_ID":32947,"DIRECTION":"UN","MASTER_ID":32947,"ec":"2.3.1.22","compounds":"a 2-acylglycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA"}
{"X":25202,"RHEA_ID":22358,"compounds":"CO2 + phosphate + phosphoenolpyruvate => diphosphate + oxaloacetate"}
{"X":25203,"RHEA_ID":32949,"compounds":"a 1,2-diacyl-sn-glycerol + CoA => a 2-acylglycerol + an acyl-CoA"}
{"X":25204,"RHEA_ID":22360,"DIRECTION":"UN","MASTER_ID":22360,"ec":"4.2.1.48","compounds":"D-glutamate = 5-oxo-D-proline + H2O"}
{"X":25205,"RHEA_ID":22361,"compounds":"D-glutamate => 5-oxo-D-proline + H2O"}
{"X":25206,"RHEA_ID":22362,"compounds":"5-oxo-D-proline + H2O => D-glutamate"}
{"X":25207,"RHEA_ID":32953,"compounds":"trehalulose => sucrose"}
{"X":25208,"RHEA_ID":22364,"DIRECTION":"UN","MASTER_ID":22364,"ec":"1.1.1.24","compounds":"L-quinate + NAD(+) = 3-dehydroquinate + H(+) + NADH"}
{"X":25209,"RHEA_ID":32955,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate"}
{"X":25210,"RHEA_ID":22365,"DIRECTION":"LR","MASTER_ID":22364,"ecocyc":"RXN-7967","metacyc":"QUINATE-5-DEHYDROGENASE-RXN","compounds":"L-quinate + NAD(+) => 3-dehydroquinate + H(+) + NADH"}
{"X":25211,"RHEA_ID":22365,"DIRECTION":"LR","MASTER_ID":22364,"ecocyc":"RXN-7967","metacyc":"RXN-7967","compounds":"L-quinate + NAD(+) => 3-dehydroquinate + H(+) + NADH"}
{"X":25212,"RHEA_ID":22366,"compounds":"3-dehydroquinate + H(+) + NADH => L-quinate + NAD(+)"}
{"X":25213,"RHEA_ID":42912,"DIRECTION":"UN","MASTER_ID":42912,"ec":"2.1.1.191","compounds":"cytidine(1962) in 23S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(1962) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":25214,"RHEA_ID":22368,"DIRECTION":"UN","MASTER_ID":22368,"ec":"5.1.3.4","compounds":"L-ribulose 5-phosphate = D-xylulose 5-phosphate"}
{"X":25215,"RHEA_ID":22369,"compounds":"L-ribulose 5-phosphate => D-xylulose 5-phosphate"}
{"X":25216,"RHEA_ID":22370,"compounds":"D-xylulose 5-phosphate => L-ribulose 5-phosphate"}
{"X":25217,"RHEA_ID":42916,"DIRECTION":"UN","MASTER_ID":42916,"ec":"2.1.1.192","compounds":"adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine"}
{"X":25218,"RHEA_ID":22372,"DIRECTION":"UN","MASTER_ID":22372,"ec":"1.7.3.5","compounds":"H2O + O2 + propionate 3-nitronate = 3-oxopropanoate + H(+) + H2O2 + nitrite"}
{"X":25219,"RHEA_ID":22373,"DIRECTION":"LR","MASTER_ID":22372,"metacyc":"3-ACI-NITROPROPANOATE-OXIDASE-RXN","compounds":"H2O + O2 + propionate 3-nitronate => 3-oxopropanoate + H(+) + H2O2 + nitrite"}
{"X":25220,"RHEA_ID":22374,"compounds":"3-oxopropanoate + H(+) + H2O2 + nitrite => H2O + O2 + propionate 3-nitronate"}
{"X":25221,"RHEA_ID":42920,"DIRECTION":"UN","MASTER_ID":42920,"ec":"2.1.1.193","compounds":"S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine"}
{"X":25222,"RHEA_ID":22376,"DIRECTION":"UN","MASTER_ID":22376,"ec":"5.4.99.12","compounds":"uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA"}
{"X":25223,"RHEA_ID":22377,"DIRECTION":"LR","MASTER_ID":22376,"ecocyc":"TRNA-PSEUDOURIDINE-SYNTHASE-I-RXN","metacyc":"TRNA-PSEUDOURIDINE-SYNTHASE-I-RXN","compounds":"uridine(38/39/40) in tRNA => pseudouridine(38/39/40) in tRNA"}
{"X":25224,"RHEA_ID":22378,"compounds":"pseudouridine(38/39/40) in tRNA => uridine(38/39/40) in tRNA"}
{"X":25225,"RHEA_ID":32970,"compounds":"a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> a fatty acid + H(+) + sn-glycero-3-phosphoethanolamine"}
{"X":25226,"RHEA_ID":22380,"DIRECTION":"UN","MASTER_ID":22380,"ec":"3.1.1.11","compounds":"[(1->4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1->4)-alpha-D-galacturonosyl](n) + n H(+) + n methanol"}
{"X":25227,"RHEA_ID":22381,"DIRECTION":"LR","MASTER_ID":22380,"metacyc":"PECTINESTERASE-RXN","compounds":"[(1->4)-alpha-D-galacturonosyl methyl ester](n) + n H2O => [(1->4)-alpha-D-galacturonosyl](n) + n H(+) + n methanol"}
{"X":25228,"RHEA_ID":22382,"compounds":"[(1->4)-alpha-D-galacturonosyl](n) + n H(+) + n methanol => [(1->4)-alpha-D-galacturonosyl methyl ester](n) + n H2O"}
{"X":25229,"RHEA_ID":32974,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + 2 H2O <=> 2 a carboxylate + 2 H(+) + sn-glycero-3-phosphoethanolamine"}
{"X":25230,"RHEA_ID":22384,"DIRECTION":"UN","MASTER_ID":22384,"ec":"3.6.1.52","compounds":"5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + H(+) + phosphate"}
{"X":25231,"RHEA_ID":22385,"DIRECTION":"LR","MASTER_ID":22384,"metacyc":"RXN-10964","reactome":"R-HSA-1855198.2","compounds":"5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O => 1D-myo-inositol hexakisphosphate + H(+) + phosphate"}
{"X":25232,"RHEA_ID":22386,"compounds":"1D-myo-inositol hexakisphosphate + H(+) + phosphate => 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O"}
{"X":25233,"RHEA_ID":42932,"DIRECTION":"UN","MASTER_ID":42932,"ec":"2.1.1.200","compounds":"cytidine(32) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":25234,"RHEA_ID":22388,"DIRECTION":"UN","MASTER_ID":22388,"ec":"2.3.1.102","compounds":"acetyl-CoA + N(6)-hydroxy-L-lysine = CoA + N(6)-acetyl-N(6)-hydroxy-L-lysine"}
{"X":25235,"RHEA_ID":22389,"DIRECTION":"LR","MASTER_ID":22388,"metacyc":"N6-HYDROXYLYSINE-O-ACETYLTRANSFERASE-RXN","compounds":"acetyl-CoA + N(6)-hydroxy-L-lysine => CoA + N(6)-acetyl-N(6)-hydroxy-L-lysine"}
{"X":25236,"RHEA_ID":22390,"compounds":"CoA + N(6)-acetyl-N(6)-hydroxy-L-lysine => acetyl-CoA + N(6)-hydroxy-L-lysine"}
{"X":25237,"RHEA_ID":42936,"DIRECTION":"UN","MASTER_ID":42936,"ec":"2.1.1.200","compounds":"S-adenosyl-L-methionine + uridine(32) in tRNA = 2'-O-methyluridine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":25238,"RHEA_ID":22392,"compounds":"(9Z,12Z)-octadecadienoate + O2 = (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate"}
{"X":25239,"RHEA_ID":22393,"compounds":"(9Z,12Z)-octadecadienoate + O2 => (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate"}
{"X":25240,"RHEA_ID":22394,"compounds":"(7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate => (9Z,12Z)-octadecadienoate + O2"}
{"X":25241,"RHEA_ID":32986,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + 2 H2O <=> 2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-1D-myo-inositol"}
{"X":25242,"RHEA_ID":22396,"DIRECTION":"UN","MASTER_ID":22396,"ec":"1.11.1.16","compounds":"1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 = glycolaldehyde + guaiacol + H2O + vanillin"}
{"X":25243,"RHEA_ID":22397,"DIRECTION":"LR","MASTER_ID":22396,"metacyc":"RXN-17139","compounds":"1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 => glycolaldehyde + guaiacol + H2O + vanillin"}
{"X":25244,"RHEA_ID":22398,"compounds":"glycolaldehyde + guaiacol + H2O + vanillin => 1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2"}
{"X":25245,"RHEA_ID":52931,"compounds":"cyclic di-3',5'-guanylate + 2 H2O <=> 2 GMP + 2 H(+)"}
{"X":25246,"RHEA_ID":22400,"DIRECTION":"UN","MASTER_ID":22400,"ec":"1.1.1.53","compounds":"androstan-3alpha,17beta-diol + NAD(+) = 17beta-hydroxyandrostanone + H(+) + NADH"}
{"X":25247,"RHEA_ID":22401,"compounds":"androstan-3alpha,17beta-diol + NAD(+) => 17beta-hydroxyandrostanone + H(+) + NADH"}
{"X":25248,"RHEA_ID":22402,"compounds":"17beta-hydroxyandrostanone + H(+) + NADH => androstan-3alpha,17beta-diol + NAD(+)"}
{"X":25249,"RHEA_ID":32994,"compounds":"2 a 1-acyl-sn-glycero-3-phosphocholine <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine"}
{"X":25250,"RHEA_ID":22404,"DIRECTION":"UN","MASTER_ID":22404,"ec":"1.1.1.203","compounds":"beta-D-galacturonate + NAD(+) = D-galactaro-1,5-lactone + H(+) + NADH"}
{"X":25251,"RHEA_ID":22405,"DIRECTION":"LR","MASTER_ID":22404,"metacyc":"URONATE-DEHYDROGENASE-RXN","compounds":"beta-D-galacturonate + NAD(+) => D-galactaro-1,5-lactone + H(+) + NADH"}
{"X":25252,"RHEA_ID":22406,"compounds":"D-galactaro-1,5-lactone + H(+) + NADH => beta-D-galacturonate + NAD(+)"}
{"X":25253,"RHEA_ID":52943,"compounds":"chenodeoxycholate + UDP-alpha-D-glucuronate <=> chenodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP"}
{"X":25254,"RHEA_ID":22408,"DIRECTION":"UN","MASTER_ID":22408,"ec":"2.5.1.1","compounds":"dimethylallyl diphosphate + isopentenyl diphosphate = (2E)-geranyl diphosphate + diphosphate"}
{"X":25255,"RHEA_ID":22409,"DIRECTION":"LR","MASTER_ID":22408,"ecocyc":"GPPSYN-RXN","reactome":"R-HSA-191322.1","compounds":"dimethylallyl diphosphate + isopentenyl diphosphate => (2E)-geranyl diphosphate + diphosphate"}
{"X":25256,"RHEA_ID":22410,"compounds":"(2E)-geranyl diphosphate + diphosphate => dimethylallyl diphosphate + isopentenyl diphosphate"}
{"X":25257,"RHEA_ID":25781,"compounds":"H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-mannosamine => 3 H(+) + 2 NADH + UDP-N-acetyl-alpha-D-mannosaminouronate"}
{"X":25258,"RHEA_ID":22412,"compounds":"anthranilate + ATP = diphosphate + N-adenylylanthranilate"}
{"X":25259,"RHEA_ID":22413,"compounds":"anthranilate + ATP => diphosphate + N-adenylylanthranilate"}
{"X":25260,"RHEA_ID":22414,"compounds":"diphosphate + N-adenylylanthranilate => anthranilate + ATP"}
{"X":25261,"RHEA_ID":52951,"compounds":"deoxycholate + UDP-alpha-D-glucuronate <=> deoxycholoyl-24-O-(beta-D-glucuronate) + UDP"}
{"X":25262,"RHEA_ID":22416,"DIRECTION":"UN","MASTER_ID":22416,"ec":"4.1.1.63","compounds":"3,4-dihydroxybenzoate + H(+) = catechol + CO2"}
{"X":25263,"RHEA_ID":22417,"compounds":"3,4-dihydroxybenzoate + H(+) => catechol + CO2"}
{"X":25264,"RHEA_ID":22418,"compounds":"catechol + CO2 => 3,4-dihydroxybenzoate + H(+)"}
{"X":25265,"RHEA_ID":52955,"compounds":"lithocholate + UDP-alpha-D-glucuronate <=> lithocholoyl-24-O-(beta-D-glucuronate) + UDP"}
{"X":25266,"RHEA_ID":22420,"DIRECTION":"UN","MASTER_ID":22420,"ec":"1.2.1.61","compounds":"cis,trans-4-hydroxymuconate semialdehyde + H2O + NAD(+) = 2 H(+) + maleylacetate + NADH"}
{"X":25267,"RHEA_ID":22421,"DIRECTION":"LR","MASTER_ID":22420,"metacyc":"1.2.1.61-RXN","compounds":"cis,trans-4-hydroxymuconate semialdehyde + H2O + NAD(+) => 2 H(+) + maleylacetate + NADH"}
{"X":25268,"RHEA_ID":22422,"compounds":"2 H(+) + maleylacetate + NADH => cis,trans-4-hydroxymuconate semialdehyde + H2O + NAD(+)"}
{"X":25269,"RHEA_ID":52959,"compounds":"hyodeoxycholate + UDP-alpha-D-glucuronate <=> hyodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP"}
{"X":25270,"RHEA_ID":22424,"DIRECTION":"UN","MASTER_ID":22424,"ec":"4.4.1.6","compounds":"an S-alkyl-L-cysteine + H2O = an alkyl thiol + NH4(+) + pyruvate"}
{"X":25271,"RHEA_ID":22425,"compounds":"an S-alkyl-L-cysteine + H2O => an alkyl thiol + NH4(+) + pyruvate"}
{"X":25272,"RHEA_ID":22426,"compounds":"an alkyl thiol + NH4(+) + pyruvate => an S-alkyl-L-cysteine + H2O"}
{"X":25273,"RHEA_ID":42971,"compounds":"cytidine(56) in tRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(56) in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":25274,"RHEA_ID":22428,"DIRECTION":"UN","MASTER_ID":22428,"ec":"1.21.3.1","compounds":"N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 = 2 H2O + isopenicillin N"}
{"X":25275,"RHEA_ID":22429,"DIRECTION":"LR","MASTER_ID":22428,"macie":"M0145","metacyc":"1.21.3.1-RXN","compounds":"N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 => 2 H2O + isopenicillin N"}
{"X":25276,"RHEA_ID":22430,"compounds":"2 H2O + isopenicillin N => N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2"}
{"X":25277,"RHEA_ID":52967,"compounds":"hyodeoxycholate + UDP-alpha-D-glucuronate <=> H(+) + hyodeoxycholate 6-O-(beta-D-glucuronate) + UDP"}
{"X":25278,"RHEA_ID":22432,"DIRECTION":"UN","MASTER_ID":22432,"ec":"1.1.1.35","compounds":"a (3S)-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH"}
{"X":25279,"RHEA_ID":22433,"DIRECTION":"LR","MASTER_ID":22432,"ecocyc":"OHACYL-COA-DEHYDROG-RXN","metacyc":"OHACYL-COA-DEHYDROG-RXN","compounds":"a (3S)-hydroxyacyl-CoA + NAD(+) => a 3-oxoacyl-CoA + H(+) + NADH"}
{"X":25280,"RHEA_ID":22434,"compounds":"a 3-oxoacyl-CoA + H(+) + NADH => a (3S)-hydroxyacyl-CoA + NAD(+)"}
{"X":25281,"RHEA_ID":33024,"DIRECTION":"LR","MASTER_ID":33023,"metacyc":"6PGLUCONDEHYDROG-RXN","compounds":"6-phospho-D-gluconate + NAD(+) => CO2 + D-ribulose 5-phosphate + NADH"}
{"X":25282,"RHEA_ID":22436,"DIRECTION":"UN","MASTER_ID":22436,"ec":"4.2.3.22","compounds":"(2E,6E)-farnesyl diphosphate + H2O = (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate"}
{"X":25283,"RHEA_ID":22437,"DIRECTION":"LR","MASTER_ID":22436,"metacyc":"RXN-8648","compounds":"(2E,6E)-farnesyl diphosphate + H2O => (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate"}
{"X":25284,"RHEA_ID":22438,"compounds":"(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}
{"X":25285,"RHEA_ID":42983,"compounds":"L-tyrosine <=> 2-aminoprop-2-enoate + phenol"}
{"X":25286,"RHEA_ID":22440,"DIRECTION":"UN","MASTER_ID":22440,"ec":"2.7.8.18","metacyc":"2.7.8.18-RXN","compounds":"UDP-alpha-D-galactose + UDP-N-acetyl-alpha-D-glucosamine = H(+) + UDP-N-acetyl-6-(alpha-D-galactose-1-phospho)-alpha-D-glucosamine + UMP"}
{"X":25287,"RHEA_ID":22441,"compounds":"UDP-alpha-D-galactose + UDP-N-acetyl-alpha-D-glucosamine => H(+) + UDP-N-acetyl-6-(alpha-D-galactose-1-phospho)-alpha-D-glucosamine + UMP"}
{"X":25288,"RHEA_ID":22442,"compounds":"H(+) + UDP-N-acetyl-6-(alpha-D-galactose-1-phospho)-alpha-D-glucosamine + UMP => UDP-alpha-D-galactose + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":25289,"RHEA_ID":52979,"compounds":"a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] <=> a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin]"}
{"X":25290,"RHEA_ID":22444,"DIRECTION":"UN","MASTER_ID":22444,"ec":"1.1.1.194","compounds":"(E)-coniferol + NADP(+) = (E)-coniferaldehyde + H(+) + NADPH"}
{"X":25291,"RHEA_ID":22444,"DIRECTION":"UN","MASTER_ID":22444,"ec":"1.1.1.195","compounds":"(E)-coniferol + NADP(+) = (E)-coniferaldehyde + H(+) + NADPH"}
{"X":25292,"RHEA_ID":22445,"compounds":"(E)-coniferol + NADP(+) => (E)-coniferaldehyde + H(+) + NADPH"}
{"X":25293,"RHEA_ID":33036,"DIRECTION":"LR","MASTER_ID":33035,"metacyc":"RXN-11653","compounds":"2-oxospirilloxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => 2,2'-dioxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":25294,"RHEA_ID":22446,"DIRECTION":"RL","MASTER_ID":22444,"metacyc":"RXN-2602","compounds":"(E)-coniferaldehyde + H(+) + NADPH => (E)-coniferol + NADP(+)"}
{"X":25295,"RHEA_ID":42993,"DIRECTION":"LR","MASTER_ID":42992,"metacyc":"RXN-15706","compounds":"all-trans-geranylgeranyl diphosphate + H2O => (R)-nephthenol + diphosphate"}
{"X":25296,"RHEA_ID":22448,"DIRECTION":"UN","MASTER_ID":22448,"ec":"2.7.1.83","compounds":"ATP + pseudouridine = ADP + H(+) + psi-UMP"}
{"X":25297,"RHEA_ID":22449,"DIRECTION":"LR","MASTER_ID":22448,"ecocyc":"PSEUDOURIDINE-KINASE-RXN","metacyc":"PSEUDOURIDINE-KINASE-RXN","compounds":"ATP + pseudouridine => ADP + H(+) + psi-UMP"}
{"X":25298,"RHEA_ID":22450,"compounds":"ADP + H(+) + psi-UMP => ATP + pseudouridine"}
{"X":25299,"RHEA_ID":42997,"DIRECTION":"LR","MASTER_ID":42996,"metacyc":"RXN-15707","compounds":"all-trans-geranylgeranyl diphosphate => (R)-cembrene A + diphosphate"}
{"X":25300,"RHEA_ID":22452,"DIRECTION":"UN","MASTER_ID":22452,"ec":"3.6.1.10","compounds":"[phosphate](n+1) + n H2O = n H(+) + (n+1) phosphate"}
{"X":25301,"RHEA_ID":33044,"DIRECTION":"LR","MASTER_ID":33043,"metacyc":"RXN-13324","compounds":"(1R,4R)-camphor + H(+) + NADPH + O2 => (+)-6-exo-hydroxycamphor + H2O + NADP(+)"}
{"X":25302,"RHEA_ID":22454,"compounds":"n H(+) + (n+1) phosphate => [phosphate](n+1) + n H2O"}
{"X":25303,"RHEA_ID":22456,"DIRECTION":"UN","MASTER_ID":22456,"ec":"3.5.3.3","compounds":"creatine + H2O = sarcosine + urea"}
{"X":25304,"RHEA_ID":33048,"DIRECTION":"LR","MASTER_ID":33047,"metacyc":"RXN-13325","compounds":"(1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin] => (+)-6-endo-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin]"}
{"X":25305,"RHEA_ID":22458,"compounds":"sarcosine + urea => creatine + H2O"}
{"X":25306,"RHEA_ID":22460,"DIRECTION":"UN","MASTER_ID":22460,"ec":"1.3.1.8","compounds":"a 2,3-saturated acyl-CoA + NADP(+) = a 2,3-dehydroacyl-CoA + H(+) + NADPH"}
{"X":25307,"RHEA_ID":33052,"DIRECTION":"LR","MASTER_ID":33051,"metacyc":"RXN-6021","compounds":"choline + NAD(+) => betaine aldehyde + H(+) + NADH"}
{"X":25308,"RHEA_ID":22462,"DIRECTION":"RL","MASTER_ID":22460,"metacyc":"ACYL-COA-DEHYDROGENASE-NADP%2b-RXN","compounds":"a 2,3-dehydroacyl-CoA + H(+) + NADPH => a 2,3-saturated acyl-CoA + NADP(+)"}
{"X":25309,"RHEA_ID":22464,"compounds":"L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase]"}
{"X":25310,"RHEA_ID":33056,"DIRECTION":"LR","MASTER_ID":33055,"ecocyc":"RXN0-6427","metacyc":"RXN0-6427","compounds":"guanosine 3'-diphosphate 5'-triphosphate + H2O => diphosphate + GTP + H(+)"}
{"X":25311,"RHEA_ID":22466,"compounds":"2 H(+) + H2O + N-hydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase] => L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":25312,"RHEA_ID":33058,"compounds":"guanosine 3'-diphosphate 5'-triphosphate + H2O <=> diphosphate + GTP + H(+)"}
{"X":25313,"RHEA_ID":22468,"DIRECTION":"UN","MASTER_ID":22468,"ec":"3.5.4.29","compounds":"GTP + 3 H2O = 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 H(+) + 2 phosphate"}
{"X":25314,"RHEA_ID":33060,"compounds":"(R)-dihydrolipoamide + NAD(+) => (R)-lipoamide + H(+) + NADH"}
{"X":25315,"RHEA_ID":22470,"compounds":"2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 H(+) + 2 phosphate => GTP + 3 H2O"}
{"X":25316,"RHEA_ID":43017,"DIRECTION":"LR","MASTER_ID":43016,"metacyc":"RXN-15577","compounds":"an S-alkyl-L-cysteine => 2-aminoprop-2-enoate + an alkyl thiol"}
{"X":25317,"RHEA_ID":22472,"DIRECTION":"UN","MASTER_ID":22472,"ec":"2.7.1.34","compounds":"(R)-pantetheine + ATP = ADP + D-pantetheine 4'-phosphate + H(+)"}
{"X":25318,"RHEA_ID":33064,"compounds":"H(+) + NAD(+) + 2 reduced [2Fe-2S]-[putidaredoxin] => NADH + 2 oxidized [2Fe-2S]-[putidaredoxin]"}
{"X":25319,"RHEA_ID":22474,"compounds":"ADP + D-pantetheine 4'-phosphate + H(+) => (R)-pantetheine + ATP"}
{"X":25320,"RHEA_ID":22476,"DIRECTION":"UN","MASTER_ID":22476,"ec":"1.7.1.9","metacyc":"1.7.1.9-RXN","compounds":"4-(hydroxyamino)quinoline N-oxide + H2O + 2 NADP(+) = 4-nitroquinoline N-oxide + 2 H(+) + 2 NADPH"}
{"X":25321,"RHEA_ID":22477,"compounds":"4-(hydroxyamino)quinoline N-oxide + H2O + 2 NADP(+) => 4-nitroquinoline N-oxide + 2 H(+) + 2 NADPH"}
{"X":25322,"RHEA_ID":33069,"compounds":"4-hydroxysphinganine + phosphate => 4-hydroxysphinganine 1-phosphate + H2O"}
{"X":25323,"RHEA_ID":33070,"compounds":"4-hydroxysphinganine 1-phosphate + H2O <=> 4-hydroxysphinganine + phosphate"}
{"X":25324,"RHEA_ID":22480,"DIRECTION":"UN","MASTER_ID":22480,"ec":"1.7.1.9","metacyc":"1.7.1.9-RXN","compounds":"4-(hydroxyamino)quinoline N-oxide + H2O + 2 NAD(+) = 4-nitroquinoline N-oxide + 2 H(+) + 2 NADH"}
{"X":25325,"RHEA_ID":22481,"compounds":"4-(hydroxyamino)quinoline N-oxide + H2O + 2 NAD(+) => 4-nitroquinoline N-oxide + 2 H(+) + 2 NADH"}
{"X":25326,"RHEA_ID":22482,"compounds":"4-nitroquinoline N-oxide + 2 H(+) + 2 NADH => 4-(hydroxyamino)quinoline N-oxide + H2O + 2 NAD(+)"}
{"X":25327,"RHEA_ID":43029,"compounds":"L-cysteate => 2-aminoprop-2-enoate + H(+) + sulfite"}
{"X":25328,"RHEA_ID":22484,"DIRECTION":"UN","MASTER_ID":22484,"ec":"3.6.1.17","compounds":"H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate = GMP + GTP + 2 H(+)"}
{"X":25329,"RHEA_ID":22485,"DIRECTION":"LR","MASTER_ID":22484,"reactome":"R-HSA-5696197.1","compounds":"H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate => GMP + GTP + 2 H(+)"}
{"X":25330,"RHEA_ID":33077,"compounds":"6-amino-6-deoxyfutalosine + H(+) + hydrogencarbonate + L-methionine => 3-[(1-carboxyvinyl)-oxy]benzoate + H2O + S-adenosyl-L-methionine"}
{"X":25331,"RHEA_ID":43033,"DIRECTION":"LR","MASTER_ID":43032,"metacyc":"RXN-15584","compounds":"3-chloro-D-alanine => 2-aminoprop-2-enoate + chloride + H(+)"}
{"X":25332,"RHEA_ID":22488,"DIRECTION":"UN","MASTER_ID":22488,"ec":"4.4.1.22","compounds":"S-(hydroxymethyl)glutathione = formaldehyde + glutathione"}
{"X":25333,"RHEA_ID":22489,"DIRECTION":"LR","MASTER_ID":22488,"ecocyc":"RXN-2961","metacyc":"RXN-2961","compounds":"S-(hydroxymethyl)glutathione => formaldehyde + glutathione"}
{"X":25334,"RHEA_ID":22490,"compounds":"formaldehyde + glutathione => S-(hydroxymethyl)glutathione"}
{"X":25335,"RHEA_ID":43037,"DIRECTION":"LR","MASTER_ID":43036,"ecocyc":"RXN-15129","metacyc":"RXN-15129","compounds":"L-cysteine => 2-aminoprop-2-enoate + H(+) + hydrogen sulfide"}
{"X":25336,"RHEA_ID":22492,"DIRECTION":"UN","MASTER_ID":22492,"ec":"3.5.3.8","compounds":"H2O + N-formimidoyl-L-glutamate = formamide + L-glutamate"}
{"X":25337,"RHEA_ID":22493,"DIRECTION":"LR","MASTER_ID":22492,"metacyc":"FORMIMINOGLUTAMASE-RXN","compounds":"H2O + N-formimidoyl-L-glutamate => formamide + L-glutamate"}
{"X":25338,"RHEA_ID":33085,"compounds":"5'-deoxyadenosine + cyclic dehypoxanthinylfutalosinate + H(+) + L-methionine => dehypoxanthine futalosine + S-adenosyl-L-methionine"}
{"X":25339,"RHEA_ID":33086,"compounds":"dehypoxanthine futalosine + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + cyclic dehypoxanthinylfutalosinate + H(+) + L-methionine"}
{"X":25340,"RHEA_ID":22500,"DIRECTION":"UN","MASTER_ID":22500,"ec":"2.3.1.218","compounds":"(E)-feruloyl-CoA + H(+) + malonyl-CoA = (E)-feruloylacetyl-CoA + CO2 + CoA"}
{"X":25341,"RHEA_ID":22501,"DIRECTION":"LR","MASTER_ID":22500,"metacyc":"RXN-11221","compounds":"(E)-feruloyl-CoA + H(+) + malonyl-CoA => (E)-feruloylacetyl-CoA + CO2 + CoA"}
{"X":25342,"RHEA_ID":33089,"compounds":"1,4-dihydroxy-6-naphthoate + chemical entity => cyclic dehypoxanthinylfutalosinate"}
{"X":25343,"RHEA_ID":33090,"compounds":"cyclic dehypoxanthinylfutalosinate <=> 1,4-dihydroxy-6-naphthoate + chemical entity"}
{"X":25344,"RHEA_ID":22504,"DIRECTION":"UN","MASTER_ID":22504,"ec":"2.8.2.26","compounds":"3'-phosphoadenylyl sulfate + quercetin 3-sulfate = adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3'-bissulfate"}
{"X":25345,"RHEA_ID":22505,"DIRECTION":"LR","MASTER_ID":22504,"metacyc":"2.8.2.26-RXN","compounds":"3'-phosphoadenylyl sulfate + quercetin 3-sulfate => adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3'-bissulfate"}
{"X":25346,"RHEA_ID":22506,"compounds":"adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3'-bissulfate => 3'-phosphoadenylyl sulfate + quercetin 3-sulfate"}
{"X":25347,"RHEA_ID":33094,"compounds":"1,4-dihydroxy-6-naphthoate + all-trans-octaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-8 + CO2 + diphosphate"}
{"X":25348,"RHEA_ID":22508,"DIRECTION":"UN","MASTER_ID":22508,"ec":"2.7.7.7","compounds":"a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)"}
{"X":25349,"RHEA_ID":22508,"DIRECTION":"UN","MASTER_ID":22508,"ec":"2.7.7.31","compounds":"a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)"}
{"X":25350,"RHEA_ID":22508,"DIRECTION":"UN","MASTER_ID":22508,"ec":"2.7.7.49","compounds":"a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)"}
{"X":25351,"RHEA_ID":22509,"compounds":"a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) => diphosphate + DNA(n+1)"}
{"X":25352,"RHEA_ID":22510,"compounds":"diphosphate + DNA(n+1) => a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n)"}
{"X":25353,"RHEA_ID":33101,"compounds":"CoA + H(+) + N(1)-acetylspermine => acetyl-CoA + spermine"}
{"X":25354,"RHEA_ID":22512,"DIRECTION":"UN","MASTER_ID":22512,"ec":"5.4.99.61","compounds":"3 H(+) + precorrin-8X = hydrogenobyrinate"}
{"X":25355,"RHEA_ID":22513,"DIRECTION":"LR","MASTER_ID":22512,"macie":"M0193","compounds":"3 H(+) + precorrin-8X => hydrogenobyrinate"}
{"X":25356,"RHEA_ID":33105,"compounds":"alpha-muurolene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":25357,"RHEA_ID":43061,"compounds":"2-O-(alpha-D-glucopyranosyl)glycerol + phosphate => beta-D-glucose 1-phosphate + glycerol"}
{"X":25358,"RHEA_ID":22516,"DIRECTION":"UN","MASTER_ID":22516,"ec":"2.7.3.4","compounds":"ATP + taurocyamine = ADP + H(+) + N-phosphotaurocyamine"}
{"X":25359,"RHEA_ID":22517,"compounds":"ATP + taurocyamine => ADP + H(+) + N-phosphotaurocyamine"}
{"X":25360,"RHEA_ID":33109,"compounds":"diphosphate + gamma-muurolene => (2E,6E)-farnesyl diphosphate"}
{"X":25361,"RHEA_ID":43065,"DIRECTION":"LR","MASTER_ID":43064,"metacyc":"RXN-15694","compounds":"(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + monacolin J carboxylate => holo-[2-methylbutanoate polyketide synthase] + lovastatin carboxylate"}
{"X":25362,"RHEA_ID":22520,"DIRECTION":"UN","MASTER_ID":22520,"ec":"1.2.3.1","compounds":"all-trans-retinal + H2O + O2 = all-trans-retinoate + H(+) + H2O2"}
{"X":25363,"RHEA_ID":22521,"DIRECTION":"LR","MASTER_ID":22520,"metacyc":"RXN-13681","compounds":"all-trans-retinal + H2O + O2 => all-trans-retinoate + H(+) + H2O2"}
{"X":25364,"RHEA_ID":33113,"compounds":"beta-copaene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":25365,"RHEA_ID":43069,"DIRECTION":"LR","MASTER_ID":43068,"metacyc":"RXN-13509","compounds":"beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 4 H(+) + 4 H2O + oleanolate + 3 oxidized [NADPH--hemoprotein reductase]"}
{"X":25366,"RHEA_ID":22524,"DIRECTION":"UN","MASTER_ID":22524,"ec":"1.3.99.39","compounds":"2 A + a carotenoid beta-end derivative = a carotenoid phi-end derivative + 2 AH2"}
{"X":25367,"RHEA_ID":22525,"DIRECTION":"LR","MASTER_ID":22524,"metacyc":"RXN-19143","compounds":"2 A + a carotenoid beta-end derivative => a carotenoid phi-end derivative + 2 AH2"}
{"X":25368,"RHEA_ID":33117,"compounds":"malonate(out) => malonate(in)"}
{"X":25369,"RHEA_ID":22527,"compounds":"2 A + a carotenoid beta-end derivative <=> a carotenoid phi-end derivative + 2 AH2"}
{"X":25370,"RHEA_ID":22528,"DIRECTION":"UN","MASTER_ID":22528,"ec":"2.4.1.159","compounds":"a flavonol 3-O-beta-D-glucoside + UDP-beta-L-rhamnose = a flavonol 3-O-[alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + H(+) + UDP"}
{"X":25371,"RHEA_ID":22529,"compounds":"a flavonol 3-O-beta-D-glucoside + UDP-beta-L-rhamnose => a flavonol 3-O-[alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + H(+) + UDP"}
{"X":25372,"RHEA_ID":33121,"compounds":"(+)-sativene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":25373,"RHEA_ID":43077,"DIRECTION":"LR","MASTER_ID":43076,"metacyc":"RXN-13504","compounds":"erythrodiol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oleanolic aldehyde + oxidized [NADPH--hemoprotein reductase]"}
{"X":25374,"RHEA_ID":22532,"compounds":"(2E)-octenedioyl-CoA + H2O = (3S)-hydroxyoctanedioyl-CoA"}
{"X":25375,"RHEA_ID":22533,"compounds":"(2E)-octenedioyl-CoA + H2O => (3S)-hydroxyoctanedioyl-CoA"}
{"X":25376,"RHEA_ID":22534,"compounds":"(3S)-hydroxyoctanedioyl-CoA => (2E)-octenedioyl-CoA + H2O"}
{"X":25377,"RHEA_ID":22535,"compounds":"(2E)-octenedioyl-CoA + H2O <=> (3S)-hydroxyoctanedioyl-CoA"}
{"X":25378,"RHEA_ID":22536,"DIRECTION":"UN","MASTER_ID":22536,"ec":"2.1.1.89","compounds":"(S)-tetrahydrocolumbamine + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + tetrahydropalmatine"}
{"X":25379,"RHEA_ID":22537,"DIRECTION":"LR","MASTER_ID":22536,"metacyc":"2.1.1.89-RXN","compounds":"(S)-tetrahydrocolumbamine + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + tetrahydropalmatine"}
{"X":25380,"RHEA_ID":33129,"compounds":"beta-D-glucose 6-phosphate + salicyl alcohol => H2O + salicin-6-phosphate"}
{"X":25381,"RHEA_ID":43085,"DIRECTION":"LR","MASTER_ID":43084,"ecocyc":"RXN-11860","metacyc":"RXN-11860","compounds":"cytidine(34) in tRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":25382,"RHEA_ID":22540,"compounds":"5'-dehydroadenosine + H2O + O2 = 9-riburonosyladenine + H(+) + H2O2"}
{"X":25383,"RHEA_ID":22541,"DIRECTION":"LR","MASTER_ID":22540,"metacyc":"RXN-11787","compounds":"5'-dehydroadenosine + H2O + O2 => 9-riburonosyladenine + H(+) + H2O2"}
{"X":25384,"RHEA_ID":33133,"compounds":"3-phenylpyruvate + tetrahydrotyrosine => L-phenylalanine + tetrahydro-4-hydroxyphenylpyruvate"}
{"X":25385,"RHEA_ID":33134,"compounds":"L-phenylalanine + tetrahydro-4-hydroxyphenylpyruvate <=> 3-phenylpyruvate + tetrahydrotyrosine"}
{"X":25386,"RHEA_ID":22544,"DIRECTION":"UN","MASTER_ID":22544,"ec":"3.3.2.2","compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine"}
{"X":25387,"RHEA_ID":22545,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O => a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine"}
{"X":25388,"RHEA_ID":33137,"compounds":"malonate(out) + Na(+)(out) => malonate(in) + Na(+)(in)"}
{"X":25389,"RHEA_ID":22548,"DIRECTION":"UN","MASTER_ID":22548,"ec":"1.4.3.20","compounds":"H2O + L-lysine + O2 = (S)-2-amino-6-oxohexanoate + H2O2 + NH4(+)"}
{"X":25390,"RHEA_ID":22549,"DIRECTION":"LR","MASTER_ID":22548,"metacyc":"1.4.3.20-RXN","compounds":"H2O + L-lysine + O2 => (S)-2-amino-6-oxohexanoate + H2O2 + NH4(+)"}
{"X":25391,"RHEA_ID":33141,"compounds":"L-alanine(in) + L-aspartate(out) => L-alanine(out) + L-aspartate(in)"}
{"X":25392,"RHEA_ID":33142,"compounds":"L-alanine(out) + L-aspartate(in) <=> L-alanine(in) + L-aspartate(out)"}
{"X":25393,"RHEA_ID":22552,"DIRECTION":"UN","MASTER_ID":22552,"ec":"2.8.2.2","compounds":"3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate + H(+)"}
{"X":25394,"RHEA_ID":22553,"compounds":"3'-phosphoadenylyl sulfate + an alcohol => adenosine 3',5'-bisphosphate + an alkyl sulfate + H(+)"}
{"X":25395,"RHEA_ID":33145,"compounds":"galactitol(out) => galactitol(in)"}
{"X":25396,"RHEA_ID":33146,"compounds":"galactitol(in) <=> galactitol(out)"}
{"X":25397,"RHEA_ID":22556,"compounds":"(S)-malate + A = AH2 + oxaloacetate"}
{"X":25398,"RHEA_ID":22557,"compounds":"(S)-malate + A => AH2 + oxaloacetate"}
{"X":25399,"RHEA_ID":33149,"compounds":"ADP + daunorubicin(out) + H(+) + phosphate => ATP + daunorubicin(in) + H2O"}
{"X":25400,"RHEA_ID":33150,"compounds":"ATP + daunorubicin(in) + H2O <=> ADP + daunorubicin(out) + H(+) + phosphate"}
{"X":25401,"RHEA_ID":22560,"DIRECTION":"UN","MASTER_ID":22560,"ec":"1.3.1.45","compounds":"(3R)-vestitone + NADP(+) = 2'-hydroxyformononetin + 2 H(+) + NADPH"}
{"X":25402,"RHEA_ID":22561,"compounds":"(3R)-vestitone + NADP(+) => 2'-hydroxyformononetin + 2 H(+) + NADPH"}
{"X":25403,"RHEA_ID":33153,"compounds":"(R)-S(6)-acetyldihydrolipoamide + CoA => (R)-dihydrolipoamide + acetyl-CoA"}
{"X":25404,"RHEA_ID":33154,"DIRECTION":"BI","MASTER_ID":33151,"metacyc":"DIHYDLIPACETRANS-RXN","compounds":"(R)-dihydrolipoamide + acetyl-CoA <=> (R)-S(6)-acetyldihydrolipoamide + CoA"}
{"X":25405,"RHEA_ID":22564,"DIRECTION":"UN","MASTER_ID":22564,"ec":"1.3.1.39","compounds":"a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + H(+) + NADPH"}
{"X":25406,"RHEA_ID":22564,"DIRECTION":"UN","MASTER_ID":22564,"ec":"1.3.1.10","compounds":"a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + H(+) + NADPH"}
{"X":25407,"RHEA_ID":33157,"compounds":"a 1-acyl-sn-glycerol + phosphate => a 1-acyl-sn-glycero-3-phosphate + H2O"}
{"X":25408,"RHEA_ID":22565,"compounds":"a 2,3-saturated acyl-[ACP] + NADP(+) => a (2E)-enoyl-[ACP] + H(+) + NADPH"}
{"X":25409,"RHEA_ID":22566,"DIRECTION":"RL","MASTER_ID":22564,"ecocyc":"ENOYL-ACP-REDUCT-NADPH-RXN","metacyc":"ENOYL-ACP-REDUCT-NADPH-RXN","compounds":"a (2E)-enoyl-[ACP] + H(+) + NADPH => a 2,3-saturated acyl-[ACP] + NADP(+)"}
{"X":25410,"RHEA_ID":33161,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+) => H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine"}
{"X":25411,"RHEA_ID":22569,"DIRECTION":"LR","MASTER_ID":22568,"metacyc":"5.3.3.15-RXN","compounds":"ascopyrone M => ascopyrone P"}
{"X":25412,"RHEA_ID":22570,"compounds":"ascopyrone P => ascopyrone M"}
{"X":25413,"RHEA_ID":33164,"compounds":"beta-nicotinamide D-riboside(in) => beta-nicotinamide D-riboside(out)"}
{"X":25414,"RHEA_ID":22572,"DIRECTION":"UN","MASTER_ID":22572,"ec":"1.5.99.5","compounds":"A + H2O + N-methyl-L-glutamate = AH2 + formaldehyde + L-glutamate"}
{"X":25415,"RHEA_ID":33166,"compounds":"beta-nicotinamide D-riboside(in) <=> beta-nicotinamide D-riboside(out)"}
{"X":25416,"RHEA_ID":22574,"compounds":"AH2 + formaldehyde + L-glutamate => A + H2O + N-methyl-L-glutamate"}
{"X":25417,"RHEA_ID":33168,"compounds":"2 a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycero-3-phospho-1D-myo-inositol"}
{"X":25418,"RHEA_ID":22576,"DIRECTION":"UN","MASTER_ID":22576,"ec":"3.1.1.81","compounds":"an N-acyl-L-homoserine lactone + H2O = an N-acyl-L-homoserine + H(+)"}
{"X":25419,"RHEA_ID":22577,"DIRECTION":"LR","MASTER_ID":22576,"metacyc":"3.1.1.81-RXN","compounds":"an N-acyl-L-homoserine lactone + H2O => an N-acyl-L-homoserine + H(+)"}
{"X":25420,"RHEA_ID":22578,"compounds":"an N-acyl-L-homoserine + H(+) => an N-acyl-L-homoserine lactone + H2O"}
{"X":25421,"RHEA_ID":22580,"DIRECTION":"UN","MASTER_ID":22580,"ec":"4.2.1.80","compounds":"(S)-4-hydroxy-2-oxopentanoate = (2Z)-2-hydroxypenta-2,4-dienoate + H2O"}
{"X":25422,"RHEA_ID":33174,"compounds":"D-maltose(in) <=> D-maltose(out)"}
{"X":25423,"RHEA_ID":22582,"DIRECTION":"RL","MASTER_ID":22580,"ecocyc":"2-OXOPENT-4-ENOATE-HYDRATASE-RXN","compounds":"(2Z)-2-hydroxypenta-2,4-dienoate + H2O => (S)-4-hydroxy-2-oxopentanoate"}
{"X":25424,"RHEA_ID":33176,"compounds":"4-hydroxyphenylacetate(in) => 4-hydroxyphenylacetate(out)"}
{"X":25425,"RHEA_ID":22584,"DIRECTION":"UN","MASTER_ID":22584,"ec":"4.99.1.1","compounds":"2 H(+) + heme b = Fe(2+) + protoporphyrin IX"}
{"X":25426,"RHEA_ID":22585,"compounds":"2 H(+) + heme b => Fe(2+) + protoporphyrin IX"}
{"X":25427,"RHEA_ID":22586,"DIRECTION":"RL","MASTER_ID":22584,"ecocyc":"PROTOHEMEFERROCHELAT-RXN","metacyc":"PROTOHEMEFERROCHELAT-RXN","reactome":"R-HSA-189465.2","compounds":"Fe(2+) + protoporphyrin IX => 2 H(+) + heme b"}
{"X":25428,"RHEA_ID":33180,"DIRECTION":"LR","MASTER_ID":33179,"metacyc":"3.1.4.11-RXN","compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O => 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)"}
{"X":25429,"RHEA_ID":22588,"compounds":"4-aminobutanal = 1-pyrroline + H2O"}
{"X":25430,"RHEA_ID":22590,"compounds":"1-pyrroline + H2O => 4-aminobutanal"}
{"X":25431,"RHEA_ID":22592,"DIRECTION":"UN","MASTER_ID":22592,"ec":"5.3.99.6","compounds":"(9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate = (10Z,15Z)-12-oxophytodienoate"}
{"X":25432,"RHEA_ID":33186,"compounds":"citrate(in) <=> citrate(out)"}
{"X":25433,"RHEA_ID":22594,"compounds":"(10Z,15Z)-12-oxophytodienoate => (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate"}
{"X":25434,"RHEA_ID":33188,"compounds":"(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":25435,"RHEA_ID":22596,"DIRECTION":"UN","MASTER_ID":22596,"ec":"3.1.1.41","compounds":"cephalosporin C + H2O = acetate + deacetylcephalosporin C + H(+)"}
{"X":25436,"RHEA_ID":33190,"compounds":"(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":25437,"RHEA_ID":22598,"compounds":"acetate + deacetylcephalosporin C + H(+) => cephalosporin C + H2O"}
{"X":25438,"RHEA_ID":33192,"compounds":"a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA => 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA"}
{"X":25439,"RHEA_ID":22600,"DIRECTION":"UN","MASTER_ID":22600,"ec":"3.1.1.53","compounds":"H2O + N-acetyl-9-O-acetylneuraminate = acetate + H(+) + N-acetylneuraminate"}
{"X":25440,"RHEA_ID":33194,"compounds":"a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA <=> 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA"}
{"X":25441,"RHEA_ID":22602,"compounds":"acetate + H(+) + N-acetylneuraminate => H2O + N-acetyl-9-O-acetylneuraminate"}
{"X":25442,"RHEA_ID":33196,"compounds":"a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}
{"X":25443,"RHEA_ID":22604,"DIRECTION":"UN","MASTER_ID":22604,"ec":"5.3.1.7","compounds":"D-mannose = D-fructose"}
{"X":25444,"RHEA_ID":33198,"compounds":"a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}
{"X":25445,"RHEA_ID":22606,"compounds":"D-fructose => D-mannose"}
{"X":25446,"RHEA_ID":33200,"compounds":"butan-1-ol + NAD(+) => butanal + H(+) + NADH"}
{"X":25447,"RHEA_ID":22608,"DIRECTION":"UN","MASTER_ID":22608,"ec":"3.5.1.18","compounds":"H2O + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate = (2S,6S)-2,6-diaminoheptanedioate + succinate"}
{"X":25448,"RHEA_ID":22610,"compounds":"(2S,6S)-2,6-diaminoheptanedioate + succinate => H2O + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate"}
{"X":25449,"RHEA_ID":33204,"compounds":"1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":25450,"RHEA_ID":22612,"DIRECTION":"UN","MASTER_ID":22612,"ec":"4.1.3.25","compounds":"(3S)-citramalyl-CoA = acetyl-CoA + pyruvate"}
{"X":25451,"RHEA_ID":22613,"DIRECTION":"LR","MASTER_ID":22612,"metacyc":"CITRAMALYL-COA-LYASE-RXN","compounds":"(3S)-citramalyl-CoA => acetyl-CoA + pyruvate"}
{"X":25452,"RHEA_ID":22614,"compounds":"acetyl-CoA + pyruvate => (3S)-citramalyl-CoA"}
{"X":25453,"RHEA_ID":33208,"DIRECTION":"LR","MASTER_ID":33207,"reactome":"R-HSA-508040.2","compounds":"ATP + H(+) + L-glutamate + NADPH => ADP + L-glutamate 5-semialdehyde + NADP(+) + phosphate"}
{"X":25454,"RHEA_ID":22616,"DIRECTION":"UN","MASTER_ID":22616,"ec":"1.21.3.5","compounds":"2 H(+) + O2 + 2 sulochrin = 2 (2R)-bisdechlorogeodin + 2 H2O"}
{"X":25455,"RHEA_ID":22617,"DIRECTION":"LR","MASTER_ID":22616,"metacyc":"1.10.3.8-RXN","compounds":"2 H(+) + O2 + 2 sulochrin => 2 (2R)-bisdechlorogeodin + 2 H2O"}
{"X":25456,"RHEA_ID":22618,"compounds":"2 (2R)-bisdechlorogeodin + 2 H2O => 2 H(+) + O2 + 2 sulochrin"}
{"X":25457,"RHEA_ID":33212,"DIRECTION":"LR","MASTER_ID":33211,"metacyc":"RXN-9190","compounds":"1,4-dihydroxy-2-naphthoate + all-trans-heptaprenyl diphosphate + H(+) => 2-demethylmenaquinol-7 + CO2 + diphosphate"}
{"X":25458,"RHEA_ID":22620,"DIRECTION":"UN","MASTER_ID":22620,"ec":"1.13.99.3","compounds":"H(+) + L-tryptophan + O2 = 3-indoleglycolaldehyde + CO2 + NH4(+)"}
{"X":25459,"RHEA_ID":22621,"DIRECTION":"LR","MASTER_ID":22620,"metacyc":"TRYPTOPHAN-2-DIOXYGENASE-RXN","compounds":"H(+) + L-tryptophan + O2 => 3-indoleglycolaldehyde + CO2 + NH4(+)"}
{"X":25460,"RHEA_ID":33215,"compounds":"all-trans-geranylgeranyl diphosphate + 3 isopentenyl diphosphate = all-trans-heptaprenyl diphosphate + 3 diphosphate"}
{"X":25461,"RHEA_ID":33216,"compounds":"all-trans-geranylgeranyl diphosphate + 3 isopentenyl diphosphate => all-trans-heptaprenyl diphosphate + 3 diphosphate"}
{"X":25462,"RHEA_ID":22624,"DIRECTION":"UN","MASTER_ID":22624,"ec":"4.1.3.39","compounds":"(S)-4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate"}
{"X":25463,"RHEA_ID":22625,"compounds":"(S)-4-hydroxy-2-oxopentanoate => acetaldehyde + pyruvate"}
{"X":25464,"RHEA_ID":33219,"DIRECTION":"UN","MASTER_ID":33219,"ec":"1.14.14.107","compounds":"ent-kaur-16-en-19-oate + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = gibberellin A12 + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}
{"X":25465,"RHEA_ID":22628,"DIRECTION":"UN","MASTER_ID":22628,"ec":"6.3.2.6","compounds":"5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate"}
{"X":25466,"RHEA_ID":22629,"DIRECTION":"LR","MASTER_ID":22628,"ecocyc":"SAICARSYN-RXN","metacyc":"SAICARSYN-RXN","reactome":"R-HSA-73805.2","compounds":"5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate => (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate"}
{"X":25467,"RHEA_ID":33223,"compounds":"2-oxobutanoate + CoA + NAD(+) = CO2 + NADH + propanoyl-CoA"}
{"X":25468,"RHEA_ID":33224,"DIRECTION":"LR","MASTER_ID":33223,"metacyc":"RXN-7790","compounds":"2-oxobutanoate + CoA + NAD(+) => CO2 + NADH + propanoyl-CoA"}
{"X":25469,"RHEA_ID":22632,"compounds":"(2E,6E,10E,14E)-geranylfarnesyl diphosphate + isopentenyl diphosphate = all-trans-hexaprenyl diphosphate + diphosphate"}
{"X":25470,"RHEA_ID":22633,"DIRECTION":"LR","MASTER_ID":22632,"metacyc":"TRANS-PENTAPRENYLTRANSFERASE-RXN","compounds":"(2E,6E,10E,14E)-geranylfarnesyl diphosphate + isopentenyl diphosphate => all-trans-hexaprenyl diphosphate + diphosphate"}
{"X":25471,"RHEA_ID":33227,"DIRECTION":"UN","MASTER_ID":33227,"ec":"4.1.1.102","compounds":"H(+) + trans-4-coumarate = 4-hydroxystyrene + CO2"}
{"X":25472,"RHEA_ID":33228,"compounds":"H(+) + trans-4-coumarate => 4-hydroxystyrene + CO2"}
{"X":25473,"RHEA_ID":22636,"DIRECTION":"UN","MASTER_ID":22636,"ec":"3.6.1.65","compounds":"dCTP + H2O = dCMP + diphosphate + H(+)"}
{"X":25474,"RHEA_ID":22636,"DIRECTION":"UN","MASTER_ID":22636,"ec":"3.6.1.9","compounds":"dCTP + H2O = dCMP + diphosphate + H(+)"}
{"X":25475,"RHEA_ID":33231,"compounds":"H2O2 + heme b = heme d cis-diol"}
{"X":25476,"RHEA_ID":22637,"DIRECTION":"LR","MASTER_ID":22636,"ecocyc":"DCTP-PYROPHOSPHATASE-RXN","metacyc":"DCTP-PYROPHOSPHATASE-RXN","compounds":"dCTP + H2O => dCMP + diphosphate + H(+)"}
{"X":25477,"RHEA_ID":22638,"compounds":"dCMP + diphosphate + H(+) => dCTP + H2O"}
{"X":25478,"RHEA_ID":33234,"DIRECTION":"BI","MASTER_ID":33231,"metacyc":"RXN-8073","compounds":"H2O2 + heme b <=> heme d cis-diol"}
{"X":25479,"RHEA_ID":33235,"DIRECTION":"UN","MASTER_ID":33235,"ec":"1.14.13.81","compounds":"2 H(+) + Mg-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 O2 = 3,8-divinyl protochlorophyllide a + 5 H2O + 3 NADP(+)"}
{"X":25480,"RHEA_ID":22641,"compounds":"NADP(+) + sphinganine => 3-oxosphinganine + H(+) + NADPH"}
{"X":25481,"RHEA_ID":22642,"DIRECTION":"RL","MASTER_ID":22640,"metacyc":"3-DEHYDROSPHINGANINE-REDUCTASE-RXN","compounds":"3-oxosphinganine + H(+) + NADPH => NADP(+) + sphinganine"}
{"X":25482,"RHEA_ID":43193,"DIRECTION":"LR","MASTER_ID":43192,"metacyc":"RXN-12478","compounds":"cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine => 2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + H(+) + S-adenosyl-L-homocysteine"}
{"X":25483,"RHEA_ID":33239,"compounds":"L-threonine + NAD(+) = aminoacetone + CO2 + NADH"}
{"X":25484,"RHEA_ID":22645,"DIRECTION":"LR","MASTER_ID":22644,"metacyc":"1.14.13.55-RXN","compounds":"O2 + protopine + reduced [NADPH--hemoprotein reductase] => 6-hydroxyprotopine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":25485,"RHEA_ID":22646,"compounds":"6-hydroxyprotopine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + protopine + reduced [NADPH--hemoprotein reductase]"}
{"X":25486,"RHEA_ID":33242,"compounds":"L-threonine + NAD(+) <=> aminoacetone + CO2 + NADH"}
{"X":25487,"RHEA_ID":33243,"DIRECTION":"UN","MASTER_ID":33243,"ec":"1.14.14.42","compounds":"L-tetrahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-7-(methylsulfanyl)heptanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":25488,"RHEA_ID":22649,"compounds":"holo-[cytochrome c] => apo-[cytochrome c] + heme b"}
{"X":25489,"RHEA_ID":22650,"compounds":"apo-[cytochrome c] + heme b => holo-[cytochrome c]"}
{"X":25490,"RHEA_ID":22652,"DIRECTION":"UN","MASTER_ID":22652,"ec":"3.1.3.69","compounds":"2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + H2O = 2-O-(alpha-D-glucopyranosyl)glycerol + phosphate"}
{"X":25491,"RHEA_ID":22653,"DIRECTION":"LR","MASTER_ID":22652,"metacyc":"3.1.3.69-RXN","compounds":"2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + H2O => 2-O-(alpha-D-glucopyranosyl)glycerol + phosphate"}
{"X":25492,"RHEA_ID":22654,"compounds":"2-O-(alpha-D-glucopyranosyl)glycerol + phosphate => 2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + H2O"}
{"X":25493,"RHEA_ID":33250,"compounds":"O2 + putrescine <=> 1-pyrroline + H2O2 + NH4(+)"}
{"X":25494,"RHEA_ID":33251,"compounds":"2 sucrose = 6-kestotriose + beta-D-glucose"}
{"X":25495,"RHEA_ID":22657,"compounds":"CDP-ethanolamine + L-serine => CMP + H(+) + L-serine-phosphoethanolamine"}
{"X":25496,"RHEA_ID":22658,"compounds":"CMP + H(+) + L-serine-phosphoethanolamine => CDP-ethanolamine + L-serine"}
{"X":25497,"RHEA_ID":33254,"compounds":"2 sucrose <=> 6-kestotriose + beta-D-glucose"}
{"X":25498,"RHEA_ID":22660,"compounds":"a fatty acid + ATP + holo-[ACP] = a fatty acyl-[ACP] + AMP + diphosphate"}
{"X":25499,"RHEA_ID":22661,"compounds":"a fatty acid + ATP + holo-[ACP] => a fatty acyl-[ACP] + AMP + diphosphate"}
{"X":25500,"RHEA_ID":22662,"compounds":"a fatty acyl-[ACP] + AMP + diphosphate => a fatty acid + ATP + holo-[ACP]"}
{"X":25501,"RHEA_ID":33258,"compounds":"2-demethylmenaquinol-7 + S-adenosyl-L-methionine <=> H(+) + menaquinol-7 + S-adenosyl-L-homocysteine"}
{"X":25502,"RHEA_ID":33259,"compounds":"4-aminoimidazole + H(+) + 2 H2O = N-formimidoylglycine + NH4(+)"}
{"X":25503,"RHEA_ID":22665,"DIRECTION":"LR","MASTER_ID":22664,"metacyc":"2.3.1.103-RXN","compounds":"2 1-O-(trans-sinapoyl)-beta-D-glucose => 1,2-di-O-sinapoyl beta-D-glucose + D-glucose"}
{"X":25504,"RHEA_ID":22666,"compounds":"1,2-di-O-sinapoyl beta-D-glucose + D-glucose => 2 1-O-(trans-sinapoyl)-beta-D-glucose"}
{"X":25505,"RHEA_ID":33262,"compounds":"4-aminoimidazole + H(+) + 2 H2O <=> N-formimidoylglycine + NH4(+)"}
{"X":25506,"RHEA_ID":33263,"DIRECTION":"UN","MASTER_ID":33263,"ec":"1.14.14.40","compounds":"L-phenylalanine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-phenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":25507,"RHEA_ID":22669,"DIRECTION":"LR","MASTER_ID":22668,"ecocyc":"LIPIDADISACCHARIDESYNTH-RXN","metacyc":"LIPIDADISACCHARIDESYNTH-RXN","compounds":"2-N,3-O-bis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl 1-phosphate + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine => H(+) + lipid A disaccharide (E. coli) + UDP"}
{"X":25508,"RHEA_ID":22670,"compounds":"H(+) + lipid A disaccharide (E. coli) + UDP => 2-N,3-O-bis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl 1-phosphate + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine"}
{"X":25509,"RHEA_ID":43221,"DIRECTION":"LR","MASTER_ID":43220,"ecocyc":"RXN0-6731","metacyc":"RXN0-6731","compounds":"guanosine(1516) in 16S rRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(1516) in 16S rRNA + S-adenosyl-L-homocysteine"}
{"X":25510,"RHEA_ID":22672,"DIRECTION":"UN","MASTER_ID":22672,"ec":"2.5.1.103","compounds":"2 (2E,6E)-farnesyl diphosphate = diphosphate + presqualene diphosphate"}
{"X":25511,"RHEA_ID":22673,"DIRECTION":"LR","MASTER_ID":22672,"metacyc":"2.5.1.21-RXN","reactome":"R-HSA-191405.1","compounds":"2 (2E,6E)-farnesyl diphosphate => diphosphate + presqualene diphosphate"}
{"X":25512,"RHEA_ID":22674,"compounds":"diphosphate + presqualene diphosphate => 2 (2E,6E)-farnesyl diphosphate"}
{"X":25513,"RHEA_ID":33270,"compounds":"(S)-2,3,4,5-tetrahydrodipicolinate + 2 H2O + meso-2,6-diaminoheptanedioate + NADP(+) <=> 2 (S)-2-amino-6-oxoheptanedioate + NADPH + NH4(+)"}
{"X":25514,"RHEA_ID":22676,"compounds":"chlorophyllide a + H(+) + NADPH + O2 = 7(1)-hydroxychlorophyllide a + H2O + NADP(+)"}
{"X":25515,"RHEA_ID":22677,"DIRECTION":"LR","MASTER_ID":22676,"metacyc":"RXN-7676","compounds":"chlorophyllide a + H(+) + NADPH + O2 => 7(1)-hydroxychlorophyllide a + H2O + NADP(+)"}
{"X":25516,"RHEA_ID":22678,"compounds":"7(1)-hydroxychlorophyllide a + H2O + NADP(+) => chlorophyllide a + H(+) + NADPH + O2"}
{"X":25517,"RHEA_ID":33275,"compounds":"a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)"}
{"X":25518,"RHEA_ID":22681,"DIRECTION":"LR","MASTER_ID":22680,"ecocyc":"DCTP-DEAM-RXN","metacyc":"DCTP-DEAM-RXN","compounds":"dCTP + H(+) + H2O => dUTP + NH4(+)"}
{"X":25519,"RHEA_ID":22682,"compounds":"dUTP + NH4(+) => dCTP + H(+) + H2O"}
{"X":25520,"RHEA_ID":33278,"compounds":"a 1,2-diacyl-sn-glycerol + H2O <=> a 2-acylglycerol + a fatty acid + H(+)"}
{"X":25521,"RHEA_ID":33279,"DIRECTION":"UN","MASTER_ID":33279,"ec":"1.14.14.156","compounds":"L-tryptophan + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-(indol-3-yl)acetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":25522,"RHEA_ID":22685,"DIRECTION":"LR","MASTER_ID":22684,"metacyc":"RXN-20196","compounds":"4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AH2 + O2 => (2R)-2-(4-aminophenyl)-L-seryl-[peptidyl-carrier protein] + A + H2O"}
{"X":25523,"RHEA_ID":22686,"compounds":"(2R)-2-(4-aminophenyl)-L-seryl-[peptidyl-carrier protein] + A + H2O => 4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AH2 + O2"}
{"X":25524,"RHEA_ID":22687,"compounds":"4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AH2 + O2 <=> (2R)-2-(4-aminophenyl)-L-seryl-[peptidyl-carrier protein] + A + H2O"}
{"X":25525,"RHEA_ID":33283,"DIRECTION":"UN","MASTER_ID":33283,"ec":"1.14.13.66","compounds":"2-hydroxycyclohexan-1-one + NADPH + O2 = 6-oxohexanoate + H2O + NADP(+)"}
{"X":25526,"RHEA_ID":22689,"DIRECTION":"LR","MASTER_ID":22688,"metacyc":"RXN-8672","compounds":"D-alanine + H2O + O2 => H2O2 + NH4(+) + pyruvate"}
{"X":25527,"RHEA_ID":22690,"compounds":"H2O2 + NH4(+) + pyruvate => D-alanine + H2O + O2"}
{"X":25528,"RHEA_ID":33287,"compounds":"A + spermidine = 1-pyrroline + AH2 + propane-1,3-diamine"}
{"X":25529,"RHEA_ID":22693,"DIRECTION":"LR","MASTER_ID":22692,"metacyc":"3-HYDROXYBENZOATE-6-MONOOXYGENASE-RXN","compounds":"3-hydroxybenzoate + H(+) + NADH + O2 => 2,5-dihydroxybenzoate + H2O + NAD(+)"}
{"X":25530,"RHEA_ID":22694,"compounds":"2,5-dihydroxybenzoate + H2O + NAD(+) => 3-hydroxybenzoate + H(+) + NADH + O2"}
{"X":25531,"RHEA_ID":33290,"compounds":"A + spermidine <=> 1-pyrroline + AH2 + propane-1,3-diamine"}
{"X":25532,"RHEA_ID":33291,"DIRECTION":"UN","MASTER_ID":33291,"ec":"1.14.14.42","compounds":"L-pentahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-8-(methylsulfanyl)octanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":25533,"RHEA_ID":22697,"DIRECTION":"LR","MASTER_ID":22696,"metacyc":"1.14.99.12-RXN","compounds":"AH2 + androst-4-ene-3,17-dione + O2 => A + H2O + testololactone"}
{"X":25534,"RHEA_ID":22698,"compounds":"A + H2O + testololactone => AH2 + androst-4-ene-3,17-dione + O2"}
{"X":25535,"RHEA_ID":43249,"compounds":"1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O => 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + phosphate"}
{"X":25536,"RHEA_ID":22700,"compounds":"gibberellin A12 aldehyde + O2 + reduced [NADPH--hemoprotein reductase] = gibberellin A12 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":25537,"RHEA_ID":22701,"DIRECTION":"LR","MASTER_ID":22700,"metacyc":"RXN1F-161","compounds":"gibberellin A12 aldehyde + O2 + reduced [NADPH--hemoprotein reductase] => gibberellin A12 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":25538,"RHEA_ID":22702,"compounds":"gibberellin A12 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => gibberellin A12 aldehyde + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":25539,"RHEA_ID":43253,"compounds":"1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O => 1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate"}
{"X":25540,"RHEA_ID":22704,"DIRECTION":"UN","MASTER_ID":22704,"ec":"3.5.5.2","compounds":"2 H2O + ricinine = 4-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate + NH4(+)"}
{"X":25541,"RHEA_ID":22705,"DIRECTION":"LR","MASTER_ID":22704,"metacyc":"3.5.5.2-RXN","compounds":"2 H2O + ricinine => 4-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate + NH4(+)"}
{"X":25542,"RHEA_ID":22706,"compounds":"4-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate + NH4(+) => 2 H2O + ricinine"}
{"X":25543,"RHEA_ID":33307,"DIRECTION":"UN","MASTER_ID":33307,"ec":"2.7.1.195","compounds":"(2R)-2-O-(alpha-D-mannosyl)-glycerate(out) + N(pros)-phospho-L-histidyl-[protein] = (2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate(in) + L-histidyl-[protein]"}
{"X":25544,"RHEA_ID":22709,"DIRECTION":"LR","MASTER_ID":22708,"metacyc":"GLUTATHIONE-THIOESTERASE-RXN","compounds":"H2O + S-acylglutathione => a carboxylate + glutathione + H(+)"}
{"X":25545,"RHEA_ID":22710,"compounds":"a carboxylate + glutathione + H(+) => H2O + S-acylglutathione"}
{"X":25546,"RHEA_ID":33311,"compounds":"2 A + hydroxylamine + NH4(+) = 2 AH2 + H(+) + H2O + N2"}
{"X":25547,"RHEA_ID":22713,"DIRECTION":"LR","MASTER_ID":22712,"ecocyc":"COBINPGUANYLYLTRANS-RXN","compounds":"adenosylcob(III)inamide phosphate + GTP + H(+) => adenosylcob(III)inamide-GDP + diphosphate"}
{"X":25548,"RHEA_ID":22714,"compounds":"adenosylcob(III)inamide-GDP + diphosphate => adenosylcob(III)inamide phosphate + GTP + H(+)"}
{"X":25549,"RHEA_ID":33315,"compounds":"a 1-acyl-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":25550,"RHEA_ID":22717,"DIRECTION":"LR","MASTER_ID":22716,"metacyc":"1.14.13.98-RXN","compounds":"cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24S)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":25551,"RHEA_ID":22718,"compounds":"(24S)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":25552,"RHEA_ID":33318,"compounds":"a 1-acyl-sn-glycero-3-phosphate + hexadecanoyl-CoA <=> 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":25553,"RHEA_ID":22720,"DIRECTION":"UN","MASTER_ID":22720,"ec":"2.7.13.1","compounds":"ATP + L-histidyl-[protein] = ADP + H(+) + N(pros)-phospho-L-histidyl-[protein]"}
{"X":25554,"RHEA_ID":33320,"compounds":"a 1-acyl-sn-glycero-3-phosphate + octadecanoyl-CoA => a 1-acyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":25555,"RHEA_ID":22722,"compounds":"ADP + H(+) + N(pros)-phospho-L-histidyl-[protein] => ATP + L-histidyl-[protein]"}
{"X":25556,"RHEA_ID":33322,"compounds":"a 1-acyl-sn-glycero-3-phosphate + octadecanoyl-CoA <=> a 1-acyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":25557,"RHEA_ID":22724,"DIRECTION":"UN","MASTER_ID":22724,"ec":"2.4.1.173","compounds":"a sterol + UDP-alpha-D-glucose = a sterol 3-beta-D-glucoside + H(+) + UDP"}
{"X":25558,"RHEA_ID":33324,"compounds":"a 1-acyl-sn-glycero-3-phosphate + tetradecanoyl-CoA => a 1-acyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":25559,"RHEA_ID":22726,"compounds":"a sterol 3-beta-D-glucoside + H(+) + UDP => a sterol + UDP-alpha-D-glucose"}
{"X":25560,"RHEA_ID":33326,"compounds":"a 1-acyl-sn-glycero-3-phosphate + tetradecanoyl-CoA <=> a 1-acyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":25561,"RHEA_ID":22728,"DIRECTION":"UN","MASTER_ID":22728,"ec":"2.9.1.1","compounds":"H(+) + L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + phosphate"}
{"X":25562,"RHEA_ID":33336,"compounds":"1,2-dioctadecanoyl-sn-glycero-3-phosphate + H2O => 1,2-dioctadecanoyl-sn-glycerol + phosphate"}
{"X":25563,"RHEA_ID":22730,"compounds":"L-selenocysteinyl-tRNA(Sec) + phosphate => H(+) + L-seryl-tRNA(Sec) + selenophosphate"}
{"X":25564,"RHEA_ID":22732,"DIRECTION":"UN","MASTER_ID":22732,"ec":"4.1.1.83","compounds":"4-hydroxyphenylacetate + H(+) = 4-methylphenol + CO2"}
{"X":25565,"RHEA_ID":33340,"compounds":"4-hydroxysphinganine + hexacosanoyl-CoA => CoA + H(+) + N-(hexacosanoyl)-(4R)-hydroxysphinganine"}
{"X":25566,"RHEA_ID":22734,"compounds":"4-methylphenol + CO2 => 4-hydroxyphenylacetate + H(+)"}
{"X":25567,"RHEA_ID":33342,"compounds":"4-hydroxysphinganine + hexacosanoyl-CoA <=> CoA + H(+) + N-(hexacosanoyl)-(4R)-hydroxysphinganine"}
{"X":25568,"RHEA_ID":22736,"DIRECTION":"UN","MASTER_ID":22736,"ec":"4.3.1.4","compounds":"5-formimidoyltetrahydrofolate + 2 H(+) = 5,10-methenyltetrahydrofolate + NH4(+)"}
{"X":25569,"RHEA_ID":22737,"compounds":"5-formimidoyltetrahydrofolate + 2 H(+) => 5,10-methenyltetrahydrofolate + NH4(+)"}
{"X":25570,"RHEA_ID":22738,"compounds":"5,10-methenyltetrahydrofolate + NH4(+) => 5-formimidoyltetrahydrofolate + 2 H(+)"}
{"X":25571,"RHEA_ID":22740,"DIRECTION":"UN","MASTER_ID":22740,"ec":"2.7.1.1","compounds":"ATP + D-hexose = ADP + D-hexose 6-phosphate + H(+)"}
{"X":25572,"RHEA_ID":33348,"DIRECTION":"LR","MASTER_ID":33347,"metacyc":"RXN-13329","compounds":"2-iminoacetate + H2O => glyoxylate + NH4(+)"}
{"X":25573,"RHEA_ID":22742,"compounds":"ADP + D-hexose 6-phosphate + H(+) => ATP + D-hexose"}
{"X":25574,"RHEA_ID":22744,"DIRECTION":"UN","MASTER_ID":22744,"ec":"2.1.1.62","compounds":"a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":25575,"RHEA_ID":33352,"compounds":"hexacosanoyl-CoA + sphinganine => CoA + H(+) + N-hexacosanoylsphinganine"}
{"X":25576,"RHEA_ID":22746,"compounds":"a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + S-adenosyl-L-methionine"}
{"X":25577,"RHEA_ID":33354,"compounds":"hexacosanoyl-CoA + sphinganine <=> CoA + H(+) + N-hexacosanoylsphinganine"}
{"X":25578,"RHEA_ID":22748,"DIRECTION":"UN","MASTER_ID":22748,"ec":"4.1.3.17","compounds":"4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate"}
{"X":25579,"RHEA_ID":33356,"compounds":"a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA => 1-octadecanoyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + CoA"}
{"X":25580,"RHEA_ID":22750,"DIRECTION":"RL","MASTER_ID":22748,"metacyc":"4.1.3.17-RXN","compounds":"2 pyruvate => 4-hydroxy-4-methyl-2-oxoglutarate"}
{"X":25581,"RHEA_ID":22752,"DIRECTION":"UN","MASTER_ID":22752,"ec":"1.17.99.4","compounds":"A + H2O + uracil = AH2 + barbiturate + H(+)"}
{"X":25582,"RHEA_ID":22753,"DIRECTION":"LR","MASTER_ID":22752,"metacyc":"URACIL-DEHYDROGENASE-RXN","compounds":"A + H2O + uracil => AH2 + barbiturate + H(+)"}
{"X":25583,"RHEA_ID":22754,"compounds":"AH2 + barbiturate + H(+) => A + H2O + uracil"}
{"X":25584,"RHEA_ID":33362,"compounds":"(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine <=> 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":25585,"RHEA_ID":22756,"DIRECTION":"UN","MASTER_ID":22756,"ec":"1.1.3.20","compounds":"a long-chain primary fatty alcohol + O2 = a long-chain fatty aldehyde + H2O2"}
{"X":25586,"RHEA_ID":33364,"DIRECTION":"LR","MASTER_ID":33363,"ecocyc":"TRANS-RXN-156","metacyc":"TRANS-RXN-156","compounds":"D-mannitol(out) + N(pros)-phospho-L-histidyl-[protein] => D-mannitol 1-phosphate(in) + L-histidyl-[protein]"}
{"X":25587,"RHEA_ID":22757,"DIRECTION":"LR","MASTER_ID":22756,"macie":"M0322","metacyc":"LONG-CHAIN-ALCOHOL-OXIDASE-RXN","compounds":"a long-chain primary fatty alcohol + O2 => a long-chain fatty aldehyde + H2O2"}
{"X":25588,"RHEA_ID":22758,"compounds":"a long-chain fatty aldehyde + H2O2 => a long-chain primary fatty alcohol + O2"}
{"X":25589,"RHEA_ID":22759,"compounds":"a long-chain primary fatty alcohol + O2 <=> a long-chain fatty aldehyde + H2O2"}
{"X":25590,"RHEA_ID":33368,"DIRECTION":"LR","MASTER_ID":33367,"ecocyc":"TRANS-RXN-157","metacyc":"TRANS-RXN-157","compounds":"D-glucose(out) + N(pros)-phospho-L-histidyl-[protein] => D-glucose 6-phosphate(in) + L-histidyl-[protein]"}
{"X":25591,"RHEA_ID":22761,"DIRECTION":"LR","MASTER_ID":22760,"metacyc":"CYPRIDINA-LUCIFERIN-2-MONOOXYGENASE-RXN","compounds":"Cypridina luciferin + O2 => CO2 + hnu + oxidized Cypridina luciferin"}
{"X":25592,"RHEA_ID":22762,"compounds":"CO2 + hnu + oxidized Cypridina luciferin => Cypridina luciferin + O2"}
{"X":25593,"RHEA_ID":33371,"DIRECTION":"UN","MASTER_ID":33371,"ec":"2.7.1.201","compounds":"alpha,alpha-trehalose(out) + N(pros)-phospho-L-histidyl-[protein] = alpha,alpha-trehalose 6-phosphate(in) + L-histidyl-[protein]"}
{"X":25594,"RHEA_ID":22764,"DIRECTION":"UN","MASTER_ID":22764,"ec":"3.1.3.36","compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate"}
{"X":25595,"RHEA_ID":22765,"DIRECTION":"LR","MASTER_ID":22764,"metacyc":"PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN","compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O => 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate"}
{"X":25596,"RHEA_ID":22766,"compounds":"1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O"}
{"X":25597,"RHEA_ID":22768,"DIRECTION":"UN","MASTER_ID":22768,"ec":"4.3.3.1","metacyc":"3-KETOVALIDOXYLAMINE-C-N-LYASE-RXN","compounds":"4-nitrophenyl-3-ketovalidamine = 4-nitroaniline + 5D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one"}
{"X":25598,"RHEA_ID":22769,"compounds":"4-nitrophenyl-3-ketovalidamine => 4-nitroaniline + 5D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one"}
{"X":25599,"RHEA_ID":22770,"compounds":"4-nitroaniline + 5D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one => 4-nitrophenyl-3-ketovalidamine"}
{"X":25600,"RHEA_ID":33379,"compounds":"4-hydroxyeicosasphinganine 1-phosphate + H2O = (4R)-hydroxyeicosasphinganine + phosphate"}
{"X":25601,"RHEA_ID":33380,"compounds":"4-hydroxyeicosasphinganine 1-phosphate + H2O => (4R)-hydroxyeicosasphinganine + phosphate"}
{"X":25602,"RHEA_ID":22773,"compounds":"L-fuconate => 2-dehydro-3-deoxy-L-fuconate + H2O"}
{"X":25603,"RHEA_ID":22774,"compounds":"2-dehydro-3-deoxy-L-fuconate + H2O => L-fuconate"}
{"X":25604,"RHEA_ID":33383,"compounds":"(S)-malate + UDP-N-acetyl-alpha-D-glucosamine = (S)-malyl N-acetyl-alpha-D-glucosaminide + H(+) + UDP"}
{"X":25605,"RHEA_ID":33384,"DIRECTION":"LR","MASTER_ID":33383,"metacyc":"RXN8J2-1","compounds":"(S)-malate + UDP-N-acetyl-alpha-D-glucosamine => (S)-malyl N-acetyl-alpha-D-glucosaminide + H(+) + UDP"}
{"X":25606,"RHEA_ID":22776,"DIRECTION":"UN","MASTER_ID":22776,"ec":"1.11.1.16","compounds":"2 H(+) + H2O2 + 2 Mn(2+) = 2 H2O + 2 Mn(3+)"}
{"X":25607,"RHEA_ID":22777,"DIRECTION":"LR","MASTER_ID":22776,"metacyc":"MANGANESE-PEROXIDASE-RXN","compounds":"2 H(+) + H2O2 + 2 Mn(2+) => 2 H2O + 2 Mn(3+)"}
{"X":25608,"RHEA_ID":22778,"compounds":"2 H2O + 2 Mn(3+) => 2 H(+) + H2O2 + 2 Mn(2+)"}
{"X":25609,"RHEA_ID":22780,"DIRECTION":"UN","MASTER_ID":22780,"ec":"1.13.11.12","compounds":"(9Z,12Z)-octadecadienoate + O2 = (13S)-hydroperoxy-(9Z,11E)-octadecadienoate"}
{"X":25610,"RHEA_ID":22781,"DIRECTION":"LR","MASTER_ID":22780,"metacyc":"LIPOXYGENASE-RXN","compounds":"(9Z,12Z)-octadecadienoate + O2 => (13S)-hydroperoxy-(9Z,11E)-octadecadienoate"}
{"X":25611,"RHEA_ID":22782,"compounds":"(13S)-hydroperoxy-(9Z,11E)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2"}
{"X":25612,"RHEA_ID":33392,"compounds":"C20 sphinganine 1-phosphate + H2O => C20 sphinganine + phosphate"}
{"X":25613,"RHEA_ID":22784,"DIRECTION":"UN","MASTER_ID":22784,"ec":"4.4.1.19","compounds":"(2R)-O-phospho-3-sulfolactate = H(+) + phosphoenolpyruvate + sulfite"}
{"X":25614,"RHEA_ID":22785,"compounds":"(2R)-O-phospho-3-sulfolactate => H(+) + phosphoenolpyruvate + sulfite"}
{"X":25615,"RHEA_ID":22786,"DIRECTION":"RL","MASTER_ID":22784,"metacyc":"4.4.1.19-RXN","compounds":"H(+) + phosphoenolpyruvate + sulfite => (2R)-O-phospho-3-sulfolactate"}
{"X":25616,"RHEA_ID":22788,"DIRECTION":"UN","MASTER_ID":22788,"ec":"2.1.1.3","compounds":"dimethylsulfonioacetate + L-homocysteine = (methylsulfanyl)acetate + H(+) + L-methionine"}
{"X":25617,"RHEA_ID":22789,"compounds":"dimethylsulfonioacetate + L-homocysteine => (methylsulfanyl)acetate + H(+) + L-methionine"}
{"X":25618,"RHEA_ID":22790,"compounds":"(methylsulfanyl)acetate + H(+) + L-methionine => dimethylsulfonioacetate + L-homocysteine"}
{"X":25619,"RHEA_ID":43343,"compounds":"[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] <=> [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]"}
{"X":25620,"RHEA_ID":22792,"DIRECTION":"UN","MASTER_ID":22792,"ec":"5.1.1.14","compounds":"isonocardicin A = nocardicin A"}
{"X":25621,"RHEA_ID":22793,"compounds":"isonocardicin A => nocardicin A"}
{"X":25622,"RHEA_ID":22794,"compounds":"nocardicin A => isonocardicin A"}
{"X":25623,"RHEA_ID":33404,"DIRECTION":"LR","MASTER_ID":33403,"metacyc":"RXN-9377","compounds":"ATP + L-threonine => diphosphate + L-threonyl-5'-AMP"}
{"X":25624,"RHEA_ID":22796,"DIRECTION":"UN","MASTER_ID":22796,"ec":"2.7.1.102","metacyc":"HAMAMELOSE-KINASE-RXN","compounds":"ATP + D-hamamelose = ADP + D-hamamelose 2'-phosphate + H(+)"}
{"X":25625,"RHEA_ID":22797,"compounds":"ATP + D-hamamelose => ADP + D-hamamelose 2'-phosphate + H(+)"}
{"X":25626,"RHEA_ID":22798,"compounds":"ADP + D-hamamelose 2'-phosphate + H(+) => ATP + D-hamamelose"}
{"X":25627,"RHEA_ID":33408,"DIRECTION":"LR","MASTER_ID":33407,"metacyc":"RXN-9376","compounds":"ATP + glycine + H(+) => diphosphate + glycyl-5'-AMP"}
{"X":25628,"RHEA_ID":22800,"DIRECTION":"UN","MASTER_ID":22800,"ec":"5.5.1.9","compounds":"cycloeucalenol = obtusifoliol"}
{"X":25629,"RHEA_ID":22801,"DIRECTION":"LR","MASTER_ID":22800,"metacyc":"CYCLOEUCALENOL-CYCLOISOMERASE-RXN","compounds":"cycloeucalenol => obtusifoliol"}
{"X":25630,"RHEA_ID":22802,"compounds":"obtusifoliol => cycloeucalenol"}
{"X":25631,"RHEA_ID":33412,"DIRECTION":"LR","MASTER_ID":33411,"metacyc":"RXN8J2-2","compounds":"(S)-malyl N-acetyl-alpha-D-glucosaminide + H2O => (S)-malyl alpha-D-glucosaminide + acetate"}
{"X":25632,"RHEA_ID":33413,"compounds":"(S)-malyl alpha-D-glucosaminide + acetate => (S)-malyl N-acetyl-alpha-D-glucosaminide + H2O"}
{"X":25633,"RHEA_ID":22805,"compounds":"(6S,9R)-vomifoliol + NAD(+) => (6S)-6-hydroxy-3-oxo-alpha-ionone + H(+) + NADH"}
{"X":25634,"RHEA_ID":22806,"compounds":"(6S)-6-hydroxy-3-oxo-alpha-ionone + H(+) + NADH => (6S,9R)-vomifoliol + NAD(+)"}
{"X":25635,"RHEA_ID":33416,"compounds":"bornane-2,6-dione + H2O => [(1S)-4-hydroxy-2,2,3-trimethylcyclopent-3-enyl]acetate + H(+)"}
{"X":25636,"RHEA_ID":33417,"compounds":"[(1S)-4-hydroxy-2,2,3-trimethylcyclopent-3-enyl]acetate + H(+) => bornane-2,6-dione + H2O"}
{"X":25637,"RHEA_ID":22809,"DIRECTION":"LR","MASTER_ID":22808,"metacyc":"RXN-7585","compounds":"6-hydroxynicotinate + H2O + O2 => 2,6-dihydroxynicotinate + H2O2"}
{"X":25638,"RHEA_ID":22810,"compounds":"2,6-dihydroxynicotinate + H2O2 => 6-hydroxynicotinate + H2O + O2"}
{"X":25639,"RHEA_ID":33420,"DIRECTION":"LR","MASTER_ID":33419,"metacyc":"R545-RXN","compounds":"[(1R)-2,2,3-trimethyl-2-oxocyclopent-3-en-1-yl]acetate + ATP + CoA => [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + AMP + diphosphate"}
{"X":25640,"RHEA_ID":33421,"compounds":"[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + AMP + diphosphate => [(1R)-2,2,3-trimethyl-2-oxocyclopent-3-en-1-yl]acetate + ATP + CoA"}
{"X":25641,"RHEA_ID":22813,"compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) => 5,10-methenyltetrahydrofolate + NADPH"}
{"X":25642,"RHEA_ID":22814,"compounds":"5,10-methenyltetrahydrofolate + NADPH => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+)"}
{"X":25643,"RHEA_ID":33424,"DIRECTION":"LR","MASTER_ID":33423,"ecocyc":"TRANS-RXN-155B","metacyc":"TRANS-RXN-155B","compounds":"N(pros)-phospho-L-histidyl-[protein] + N,N'-diacetylchitobiose(out) => diacetylchitobiose-6'-phosphate(in) + L-histidyl-[protein]"}
{"X":25644,"RHEA_ID":22816,"DIRECTION":"UN","MASTER_ID":22816,"ec":"5.3.1.5","compounds":"D-xylose = D-xylulose"}
{"X":25645,"RHEA_ID":22817,"compounds":"D-xylose => D-xylulose"}
{"X":25646,"RHEA_ID":22818,"compounds":"D-xylulose => D-xylose"}
{"X":25647,"RHEA_ID":33428,"DIRECTION":"LR","MASTER_ID":33427,"metacyc":"RXN8J2-3","compounds":"(S)-malyl alpha-D-glucosaminide + L-cysteine => bacillithiol + H2O"}
{"X":25648,"RHEA_ID":22820,"DIRECTION":"UN","MASTER_ID":22820,"ec":"2.4.2.n3","compounds":"3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP"}
{"X":25649,"RHEA_ID":22821,"compounds":"3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose => 3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP"}
{"X":25650,"RHEA_ID":22822,"compounds":"3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP => 3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose"}
{"X":25651,"RHEA_ID":22823,"compounds":"3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose <=> 3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP"}
{"X":25652,"RHEA_ID":33433,"compounds":"(3E)-2-oxohex-3-enedioate => (2Z,4E)-2-hydroxyhexa-2,4-dienedioate"}
{"X":25653,"RHEA_ID":22825,"compounds":"2'-deoxyuridine + phosphate => 2-deoxy-alpha-D-ribose 1-phosphate + uracil"}
{"X":25654,"RHEA_ID":22826,"compounds":"2-deoxy-alpha-D-ribose 1-phosphate + uracil => 2'-deoxyuridine + phosphate"}
{"X":25655,"RHEA_ID":33436,"DIRECTION":"LR","MASTER_ID":33435,"metacyc":"RXN3O-203","compounds":"24-methylene-5alpha-cholest-8-en-3beta-ol => episterol"}
{"X":25656,"RHEA_ID":33437,"compounds":"episterol => 24-methylene-5alpha-cholest-8-en-3beta-ol"}
{"X":25657,"RHEA_ID":22829,"DIRECTION":"LR","MASTER_ID":22828,"ecocyc":"HISTPRATPHYD-RXN","metacyc":"HISTPRATPHYD-RXN","compounds":"1-(5-phospho-beta-D-ribosyl)-ATP + H2O => 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)"}
{"X":25658,"RHEA_ID":22830,"compounds":"1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+) => 1-(5-phospho-beta-D-ribosyl)-ATP + H2O"}
{"X":25659,"RHEA_ID":33440,"DIRECTION":"LR","MASTER_ID":33439,"metacyc":"RXN-17511","compounds":"glyoxal + H2O + O2 => glyoxylate + H(+) + H2O2"}
{"X":25660,"RHEA_ID":33441,"compounds":"glyoxylate + H(+) + H2O2 => glyoxal + H2O + O2"}
{"X":25661,"RHEA_ID":22833,"DIRECTION":"LR","MASTER_ID":22832,"metacyc":"FORMIMINOGLUTAMATE-DEIMINASE-RXN","compounds":"H2O + N-formimidoyl-L-glutamate => N-formyl-L-glutamate + NH4(+)"}
{"X":25662,"RHEA_ID":22834,"compounds":"N-formyl-L-glutamate + NH4(+) => H2O + N-formimidoyl-L-glutamate"}
{"X":25663,"RHEA_ID":33448,"DIRECTION":"LR","MASTER_ID":33447,"metacyc":"RXN66-313","compounds":"4alpha-carboxyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) => 4-methyl-5alpha-cholesta-8,24-dien-3-one + CO2 + NADPH"}
{"X":25664,"RHEA_ID":33449,"compounds":"4-methyl-5alpha-cholesta-8,24-dien-3-one + CO2 + NADPH => 4alpha-carboxyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+)"}
{"X":25665,"RHEA_ID":22837,"compounds":"a fatty acyl-[ACP] + H(+) + malonyl-[ACP] => a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]"}
{"X":25666,"RHEA_ID":22838,"compounds":"a 3-oxoacyl-[ACP] + CO2 + holo-[ACP] => a fatty acyl-[ACP] + H(+) + malonyl-[ACP]"}
{"X":25667,"RHEA_ID":33453,"compounds":"AH2 + formaldehyde + N(6)-methyl-L-lysyl-[protein] => A + H2O + N(6),N(6)-dimethyl-L-lysyl-[protein]"}
{"X":25668,"RHEA_ID":22841,"compounds":"D-glutamine + H2O => D-glutamate + NH4(+)"}
{"X":25669,"RHEA_ID":22842,"compounds":"D-glutamate + NH4(+) => D-glutamine + H2O"}
{"X":25670,"RHEA_ID":33456,"compounds":"4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) => CO2 + NADPH + zymosterone"}
{"X":25671,"RHEA_ID":33457,"compounds":"CO2 + NADPH + zymosterone => 4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+)"}
{"X":25672,"RHEA_ID":22845,"DIRECTION":"LR","MASTER_ID":22844,"metacyc":"RXN-4511","compounds":"(6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] => glyceollin I + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":25673,"RHEA_ID":22846,"compounds":"glyceollin I + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":25674,"RHEA_ID":33460,"compounds":"H(+) + NADPH + zymosterone => 5alpha-cholesta-8,24-dien-3beta-ol + NADP(+)"}
{"X":25675,"RHEA_ID":33461,"compounds":"5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) => H(+) + NADPH + zymosterone"}
{"X":25676,"RHEA_ID":22849,"compounds":"(3S)-hydroxyoctanedioyl-CoA + NAD(+) => 3-oxooctanedioyl-CoA + H(+) + NADH"}
{"X":25677,"RHEA_ID":22850,"compounds":"3-oxooctanedioyl-CoA + H(+) + NADH => (3S)-hydroxyoctanedioyl-CoA + NAD(+)"}
{"X":25678,"RHEA_ID":22851,"compounds":"(3S)-hydroxyoctanedioyl-CoA + NAD(+) <=> 3-oxooctanedioyl-CoA + H(+) + NADH"}
{"X":25679,"RHEA_ID":33465,"compounds":"ergosta-5,7,24(28)-trien-3beta-ol + 2 H2O + NADP(+) => episterol + H(+) + NADPH + O2"}
{"X":25680,"RHEA_ID":22853,"compounds":"L-serine + pyruvate => 3-hydroxypyruvate + L-alanine"}
{"X":25681,"RHEA_ID":22854,"compounds":"3-hydroxypyruvate + L-alanine => L-serine + pyruvate"}
{"X":25682,"RHEA_ID":33468,"DIRECTION":"LR","MASTER_ID":33467,"metacyc":"RXN3O-227","compounds":"ergosta-5,7,24(28)-trien-3beta-ol + H(+) + NADPH + O2 => ergosta-5,7,22,24(28)-tetraen-3beta-ol + 2 H2O + NADP(+)"}
{"X":25683,"RHEA_ID":22856,"DIRECTION":"UN","MASTER_ID":22856,"ec":"2.3.1.150","compounds":"(7S)-salutaridinol + acetyl-CoA = (7S)-O-acetylsalutaridinol + CoA"}
{"X":25684,"RHEA_ID":22857,"DIRECTION":"LR","MASTER_ID":22856,"metacyc":"2.3.1.150-RXN","compounds":"(7S)-salutaridinol + acetyl-CoA => (7S)-O-acetylsalutaridinol + CoA"}
{"X":25685,"RHEA_ID":22858,"compounds":"(7S)-O-acetylsalutaridinol + CoA => (7S)-salutaridinol + acetyl-CoA"}
{"X":25686,"RHEA_ID":33472,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-(4R)-4-hydroxysphinganine => a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol"}
{"X":25687,"RHEA_ID":33473,"compounds":"a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-(4R)-4-hydroxysphinganine"}
{"X":25688,"RHEA_ID":22861,"DIRECTION":"LR","MASTER_ID":22860,"ecocyc":"NICONUCADENYLYLTRAN-RXN","metacyc":"NICONUCADENYLYLTRAN-RXN","reactome":"R-HSA-197235.5","compounds":"ATP + H(+) + nicotinate beta-D-ribonucleotide => deamido-NAD(+) + diphosphate"}
{"X":25689,"RHEA_ID":22861,"DIRECTION":"LR","MASTER_ID":22860,"ecocyc":"NICONUCADENYLYLTRAN-RXN","metacyc":"NICONUCADENYLYLTRAN-RXN","reactome":"R-HSA-200512.4","compounds":"ATP + H(+) + nicotinate beta-D-ribonucleotide => deamido-NAD(+) + diphosphate"}
{"X":25690,"RHEA_ID":22861,"DIRECTION":"LR","MASTER_ID":22860,"ecocyc":"NICONUCADENYLYLTRAN-RXN","metacyc":"NICONUCADENYLYLTRAN-RXN","reactome":"R-HSA-200474.4","compounds":"ATP + H(+) + nicotinate beta-D-ribonucleotide => deamido-NAD(+) + diphosphate"}
{"X":25691,"RHEA_ID":33477,"compounds":"a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-(1D-myo-inositol) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acylsphinganine"}
{"X":25692,"RHEA_ID":33478,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acylsphinganine <=> a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-(1D-myo-inositol)"}
{"X":25693,"RHEA_ID":22864,"DIRECTION":"UN","MASTER_ID":22864,"ec":"5.1.1.5","compounds":"L-lysine = D-lysine"}
{"X":25694,"RHEA_ID":22865,"DIRECTION":"LR","MASTER_ID":22864,"metacyc":"LYSINE-RACEMASE-RXN","compounds":"L-lysine => D-lysine"}
{"X":25695,"RHEA_ID":22866,"compounds":"D-lysine => L-lysine"}
{"X":25696,"RHEA_ID":43421,"compounds":"1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + ATP => 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":25697,"RHEA_ID":22868,"DIRECTION":"UN","MASTER_ID":22868,"ec":"4.5.1.5","compounds":"3-chloro-L-alanine + thioglycolate = chloride + H(+) + S-carboxymethyl-L-cysteine"}
{"X":25698,"RHEA_ID":22869,"compounds":"3-chloro-L-alanine + thioglycolate => chloride + H(+) + S-carboxymethyl-L-cysteine"}
{"X":25699,"RHEA_ID":22870,"compounds":"chloride + H(+) + S-carboxymethyl-L-cysteine => 3-chloro-L-alanine + thioglycolate"}
{"X":25700,"RHEA_ID":43425,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":25701,"RHEA_ID":22872,"DIRECTION":"UN","MASTER_ID":22872,"ec":"1.14.11.7","compounds":"2-oxoglutarate + L-prolyl-[procollagen] + O2 = CO2 + succinate + trans-3-hydroxy-L-prolyl-[procollagen]"}
{"X":25702,"RHEA_ID":22873,"DIRECTION":"LR","MASTER_ID":22872,"metacyc":"PROCOLLAGEN-PROLINE-3-DIOXYGENASE-RXN","compounds":"2-oxoglutarate + L-prolyl-[procollagen] + O2 => CO2 + succinate + trans-3-hydroxy-L-prolyl-[procollagen]"}
{"X":25703,"RHEA_ID":22874,"compounds":"CO2 + succinate + trans-3-hydroxy-L-prolyl-[procollagen] => 2-oxoglutarate + L-prolyl-[procollagen] + O2"}
{"X":25704,"RHEA_ID":43429,"compounds":"1,2-didecanoyl-sn-glycerol + ATP => 1,2-didecanoyl-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":25705,"RHEA_ID":22876,"DIRECTION":"UN","MASTER_ID":22876,"ec":"3.5.1.86","compounds":"(R)-mandelamide + H2O = (R)-mandelate + NH4(+)"}
{"X":25706,"RHEA_ID":22877,"compounds":"(R)-mandelamide + H2O => (R)-mandelate + NH4(+)"}
{"X":25707,"RHEA_ID":22878,"compounds":"(R)-mandelate + NH4(+) => (R)-mandelamide + H2O"}
{"X":25708,"RHEA_ID":43433,"DIRECTION":"LR","MASTER_ID":43432,"metacyc":"RXN-17642","compounds":"2 [Fe(III)cytochrome c] + butan-1-ol => 2 [Fe(II)cytochrome c] + butanal + 2 H(+)"}
{"X":25709,"RHEA_ID":22880,"DIRECTION":"UN","MASTER_ID":22880,"ec":"2.6.1.79","compounds":"2-oxoglutarate + L-arogenate = L-glutamate + prephenate"}
{"X":25710,"RHEA_ID":22881,"compounds":"2-oxoglutarate + L-arogenate => L-glutamate + prephenate"}
{"X":25711,"RHEA_ID":22882,"compounds":"L-glutamate + prephenate => 2-oxoglutarate + L-arogenate"}
{"X":25712,"RHEA_ID":43437,"DIRECTION":"LR","MASTER_ID":43436,"metacyc":"RXN-17517","compounds":"coproporphyrinogen III + 3 O2 => coproporphyrin III + 3 H2O2"}
{"X":25713,"RHEA_ID":22884,"DIRECTION":"UN","MASTER_ID":22884,"ec":"2.6.1.73","compounds":"glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine"}
{"X":25714,"RHEA_ID":22885,"compounds":"glyoxylate + L-methionine => 4-methylsulfanyl-2-oxobutanoate + glycine"}
{"X":25715,"RHEA_ID":22886,"compounds":"4-methylsulfanyl-2-oxobutanoate + glycine => glyoxylate + L-methionine"}
{"X":25716,"RHEA_ID":43441,"compounds":"hexadecanoate + sphinganine => H2O + N-hexadecanoylsphinganine"}
{"X":25717,"RHEA_ID":22888,"DIRECTION":"UN","MASTER_ID":22888,"ec":"5.4.99.2","compounds":"(R)-methylmalonyl-CoA = succinyl-CoA"}
{"X":25718,"RHEA_ID":22889,"DIRECTION":"LR","MASTER_ID":22888,"reactome":"R-HSA-71010.2","compounds":"(R)-methylmalonyl-CoA => succinyl-CoA"}
{"X":25719,"RHEA_ID":22890,"DIRECTION":"RL","MASTER_ID":22888,"macie":"M0062","compounds":"succinyl-CoA => (R)-methylmalonyl-CoA"}
{"X":25720,"RHEA_ID":43445,"compounds":"1,2-ditetradecanoyl-sn-glycerol + ATP => 1,2-ditetradecanoyl-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":25721,"RHEA_ID":22892,"DIRECTION":"UN","MASTER_ID":22892,"ec":"1.5.1.15","compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH"}
{"X":25722,"RHEA_ID":22893,"DIRECTION":"LR","MASTER_ID":22892,"metacyc":"1.5.1.15-RXN","compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NAD(+) => 5,10-methenyltetrahydrofolate + NADH"}
{"X":25723,"RHEA_ID":22894,"compounds":"5,10-methenyltetrahydrofolate + NADH => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NAD(+)"}
{"X":25724,"RHEA_ID":33510,"compounds":"sphing-4-enine 1-phosphate <=> (2E)-hexadecenal + phosphoethanolamine"}
{"X":25725,"RHEA_ID":22896,"DIRECTION":"UN","MASTER_ID":22896,"ec":"2.3.1.86","compounds":"acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH = a long-chain fatty acyl-CoA + n CO2 + n CoA + H2O + 2n NADP(+)"}
{"X":25726,"RHEA_ID":22897,"DIRECTION":"LR","MASTER_ID":22896,"metacyc":"FATTY-ACYL-COA-SYNTHASE-RXN","compounds":"acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH => a long-chain fatty acyl-CoA + n CO2 + n CoA + H2O + 2n NADP(+)"}
{"X":25727,"RHEA_ID":22898,"compounds":"a long-chain fatty acyl-CoA + n CO2 + n CoA + H2O + 2n NADP(+) => acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH"}
{"X":25728,"RHEA_ID":33514,"compounds":"4-hydroxysphinganine 1-phosphate <=> 2-hydroxyhexadecanal + phosphoethanolamine"}
{"X":25729,"RHEA_ID":22900,"DIRECTION":"UN","MASTER_ID":22900,"ec":"1.1.1.303","compounds":"(R)-acetoin + NAD(+) = diacetyl + H(+) + NADH"}
{"X":25730,"RHEA_ID":33516,"DIRECTION":"LR","MASTER_ID":33515,"metacyc":"RXN-11404","compounds":"2 5,6-dihydroxyindole + O2 => 2 H2O + 2 indole-5,6-quinone"}
{"X":25731,"RHEA_ID":22902,"DIRECTION":"RL","MASTER_ID":22900,"metacyc":"RXN-11036","compounds":"diacetyl + H(+) + NADH => (R)-acetoin + NAD(+)"}
{"X":25732,"RHEA_ID":22904,"compounds":"ent-7alpha-hydroxykaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase] = gibberellin A12 aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":25733,"RHEA_ID":33520,"DIRECTION":"LR","MASTER_ID":33519,"metacyc":"RXN3O-1380","compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + sphinganine => 4-hydroxysphinganine + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":25734,"RHEA_ID":22906,"compounds":"gibberellin A12 aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => ent-7alpha-hydroxykaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":25735,"RHEA_ID":33522,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + sphinganine <=> 4-hydroxysphinganine + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":25736,"RHEA_ID":22908,"DIRECTION":"UN","MASTER_ID":22908,"ec":"3.5.4.46","compounds":"3',5'-cyclic AMP + H(+) + H2O = 3',5'-cyclic IMP + NH4(+)"}
{"X":25737,"RHEA_ID":33524,"compounds":"ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate + H2O => acetate + ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+)"}
{"X":25738,"RHEA_ID":22910,"compounds":"3',5'-cyclic IMP + NH4(+) => 3',5'-cyclic AMP + H(+) + H2O"}
{"X":25739,"RHEA_ID":33526,"compounds":"ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate + H2O <=> acetate + ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+)"}
{"X":25740,"RHEA_ID":22912,"DIRECTION":"UN","MASTER_ID":22912,"ec":"2.6.1.66","compounds":"L-valine + pyruvate = 3-methyl-2-oxobutanoate + L-alanine"}
{"X":25741,"RHEA_ID":22913,"compounds":"L-valine + pyruvate => 3-methyl-2-oxobutanoate + L-alanine"}
{"X":25742,"RHEA_ID":22914,"compounds":"3-methyl-2-oxobutanoate + L-alanine => L-valine + pyruvate"}
{"X":25743,"RHEA_ID":33530,"compounds":"acetyl-CoA + ergosta-5,7,22,24(28)-tetraen-3beta-ol <=> CoA + ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate"}
{"X":25744,"RHEA_ID":22916,"DIRECTION":"UN","MASTER_ID":22916,"ec":"1.14.13.84","compounds":"4'-hydroxyacetophenone + H(+) + NADPH + O2 = 4-acetoxyphenol + H2O + NADP(+)"}
{"X":25745,"RHEA_ID":33536,"compounds":"H2O + lanosteryl ester => a carboxylate + H(+) + lanosterol"}
{"X":25746,"RHEA_ID":22918,"compounds":"4-acetoxyphenol + H2O + NADP(+) => 4'-hydroxyacetophenone + H(+) + NADPH + O2"}
{"X":25747,"RHEA_ID":33538,"compounds":"H2O + lanosteryl ester <=> a carboxylate + H(+) + lanosterol"}
{"X":25748,"RHEA_ID":22920,"DIRECTION":"UN","MASTER_ID":22920,"ec":"2.6.1.50","compounds":"L-glutamine + scyllo-inosose = 1-amino-1-deoxy-scyllo-inositol + 2-oxoglutaramate"}
{"X":25749,"RHEA_ID":33540,"compounds":"ergosteryl ester + H2O => a carboxylate + ergosterol + H(+)"}
{"X":25750,"RHEA_ID":22922,"compounds":"1-amino-1-deoxy-scyllo-inositol + 2-oxoglutaramate => L-glutamine + scyllo-inosose"}
{"X":25751,"RHEA_ID":33542,"compounds":"ergosteryl ester + H2O <=> a carboxylate + ergosterol + H(+)"}
{"X":25752,"RHEA_ID":22924,"DIRECTION":"UN","MASTER_ID":22924,"ec":"3.5.4.12","compounds":"dCMP + H(+) + H2O = dUMP + NH4(+)"}
{"X":25753,"RHEA_ID":22925,"DIRECTION":"LR","MASTER_ID":22924,"metacyc":"DCMP-DEAMINASE-RXN","reactome":"R-HSA-73596.4","compounds":"dCMP + H(+) + H2O => dUMP + NH4(+)"}
{"X":25754,"RHEA_ID":22926,"compounds":"dUMP + NH4(+) => dCMP + H(+) + H2O"}
{"X":25755,"RHEA_ID":33546,"compounds":"ergosteryl palmitate + H2O <=> ergosterol + H(+) + hexadecanoate"}
{"X":25756,"RHEA_ID":22928,"DIRECTION":"UN","MASTER_ID":22928,"ec":"3.5.1.51","compounds":"4-acetamidobutanoyl-CoA + H2O = 4-aminobutanoyl-CoA + acetate"}
{"X":25757,"RHEA_ID":33548,"compounds":"H2O + lanosteryl hexadecanoate => H(+) + hexadecanoate + lanosterol"}
{"X":25758,"RHEA_ID":22930,"compounds":"4-aminobutanoyl-CoA + acetate => 4-acetamidobutanoyl-CoA + H2O"}
{"X":25759,"RHEA_ID":33550,"compounds":"H2O + lanosteryl hexadecanoate <=> H(+) + hexadecanoate + lanosterol"}
{"X":25760,"RHEA_ID":22932,"DIRECTION":"UN","MASTER_ID":22932,"ec":"2.4.1.38","compounds":"an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP"}
{"X":25761,"RHEA_ID":22933,"DIRECTION":"LR","MASTER_ID":22932,"metacyc":"2.4.1.38-RXN","compounds":"an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP"}
{"X":25762,"RHEA_ID":22934,"compounds":"a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose"}
{"X":25763,"RHEA_ID":33554,"compounds":"an N-acylsphinganine + H2O <=> a fatty acid + sphinganine"}
{"X":25764,"RHEA_ID":22936,"DIRECTION":"UN","MASTER_ID":22936,"ec":"3.5.1.25","compounds":"H2O + N-acetyl-D-glucosamine 6-phosphate = acetate + D-glucosamine 6-phosphate"}
{"X":25765,"RHEA_ID":33556,"compounds":"an N-acyl-(4R)-4-hydroxysphinganine + H2O => 4-hydroxysphinganine + a fatty acid"}
{"X":25766,"RHEA_ID":22938,"compounds":"acetate + D-glucosamine 6-phosphate => H2O + N-acetyl-D-glucosamine 6-phosphate"}
{"X":25767,"RHEA_ID":33558,"compounds":"an N-acyl-(4R)-4-hydroxysphinganine + H2O <=> 4-hydroxysphinganine + a fatty acid"}
{"X":25768,"RHEA_ID":22940,"DIRECTION":"UN","MASTER_ID":22940,"ec":"2.7.3.3","compounds":"ATP + L-arginine = ADP + H(+) + N(omega)-phospho-L-arginine"}
{"X":25769,"RHEA_ID":22941,"DIRECTION":"LR","MASTER_ID":22940,"macie":"M0086","compounds":"ATP + L-arginine => ADP + H(+) + N(omega)-phospho-L-arginine"}
{"X":25770,"RHEA_ID":22942,"compounds":"ADP + H(+) + N(omega)-phospho-L-arginine => ATP + L-arginine"}
{"X":25771,"RHEA_ID":43497,"DIRECTION":"LR","MASTER_ID":43496,"metacyc":"RXN-15920","compounds":"L-gulonate + NAD(+) => H(+) + keto-D-fructuronate + NADH"}
{"X":25772,"RHEA_ID":22944,"DIRECTION":"UN","MASTER_ID":22944,"ec":"1.1.1.277","metacyc":"1.1.1.277-RXN","compounds":"3beta-hydroxy-5beta-pregnane-20-one + NADP(+) = 5beta-pregnan-3,20-dione + H(+) + NADPH"}
{"X":25773,"RHEA_ID":33564,"DIRECTION":"LR","MASTER_ID":33563,"metacyc":"RXN3O-458","compounds":"4-hydroxysphinganine + ATP => 4-hydroxysphinganine 1-phosphate + ADP + H(+)"}
{"X":25774,"RHEA_ID":22946,"compounds":"5beta-pregnan-3,20-dione + H(+) + NADPH => 3beta-hydroxy-5beta-pregnane-20-one + NADP(+)"}
{"X":25775,"RHEA_ID":33566,"compounds":"4-hydroxysphinganine + ATP <=> 4-hydroxysphinganine 1-phosphate + ADP + H(+)"}
{"X":25776,"RHEA_ID":22948,"DIRECTION":"UN","MASTER_ID":22948,"ec":"4.1.2.40","compounds":"D-tagatofuranose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate"}
{"X":25777,"RHEA_ID":33568,"compounds":"A + ethanol => acetaldehyde + AH2"}
{"X":25778,"RHEA_ID":22950,"compounds":"D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate => D-tagatofuranose 1,6-bisphosphate"}
{"X":25779,"RHEA_ID":33570,"DIRECTION":"BI","MASTER_ID":33567,"metacyc":"RXN-11454","compounds":"A + ethanol <=> acetaldehyde + AH2"}
{"X":25780,"RHEA_ID":22952,"compounds":"O2 + octanedioyl-CoA = (2E)-octenedioyl-CoA + H2O2"}
{"X":25781,"RHEA_ID":33572,"DIRECTION":"LR","MASTER_ID":33571,"metacyc":"RXN-11451","compounds":"A + methanol => AH2 + formaldehyde"}
{"X":25782,"RHEA_ID":22954,"compounds":"(2E)-octenedioyl-CoA + H2O2 => O2 + octanedioyl-CoA"}
{"X":25783,"RHEA_ID":22955,"compounds":"O2 + octanedioyl-CoA <=> (2E)-octenedioyl-CoA + H2O2"}
{"X":25784,"RHEA_ID":22956,"DIRECTION":"UN","MASTER_ID":22956,"ec":"1.14.99.19","compounds":"1-(1,2-saturated alkyl)-2-acyl-sn-glycero-3-phosphoethanolamine + AH2 + O2 = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + A + 2 H2O"}
{"X":25785,"RHEA_ID":33576,"compounds":"beta-D-mannose + inositol phosphophytoceramide => H2O + mannosylinositol phosphophytoceramide"}
{"X":25786,"RHEA_ID":22958,"compounds":"1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + A + 2 H2O => 1-(1,2-saturated alkyl)-2-acyl-sn-glycero-3-phosphoethanolamine + AH2 + O2"}
{"X":25787,"RHEA_ID":22960,"DIRECTION":"UN","MASTER_ID":22960,"ec":"1.14.14.88","compounds":"formononetin + O2 + reduced [NADPH--hemoprotein reductase] = calycosin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":25788,"RHEA_ID":33580,"DIRECTION":"LR","MASTER_ID":33579,"metacyc":"RXN-13585","compounds":"NAD(+) + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate => H(+) + NADH + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate"}
{"X":25789,"RHEA_ID":22962,"compounds":"calycosin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => formononetin + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":25790,"RHEA_ID":43517,"DIRECTION":"LR","MASTER_ID":43516,"metacyc":"RXN-15853","compounds":"2-carboxy-5-formylfuran + H2O => 2-carboxy-5-(dihydroxymethyl)furan"}
{"X":25791,"RHEA_ID":22964,"DIRECTION":"UN","MASTER_ID":22964,"ec":"4.1.1.17","compounds":"H(+) + L-ornithine = CO2 + putrescine"}
{"X":25792,"RHEA_ID":33584,"compounds":"L-glutamate + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate => 2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate"}
{"X":25793,"RHEA_ID":22966,"compounds":"CO2 + putrescine => H(+) + L-ornithine"}
{"X":25794,"RHEA_ID":22968,"DIRECTION":"UN","MASTER_ID":22968,"ec":"1.2.1.57","compounds":"butanal + CoA + NAD(+) = butanoyl-CoA + H(+) + NADH"}
{"X":25795,"RHEA_ID":33588,"DIRECTION":"LR","MASTER_ID":33587,"metacyc":"RXN-13589","compounds":"acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate => CoA + H(+) + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate"}
{"X":25796,"RHEA_ID":22970,"compounds":"butanoyl-CoA + H(+) + NADH => butanal + CoA + NAD(+)"}
{"X":25797,"RHEA_ID":43525,"DIRECTION":"LR","MASTER_ID":43524,"ecocyc":"RXN-16001","metacyc":"RXN-16001","compounds":"L-allo-threonine + NADP(+) => aminoacetone + CO2 + NADPH"}
{"X":25798,"RHEA_ID":22972,"DIRECTION":"UN","MASTER_ID":22972,"ec":"1.2.1.57","compounds":"butanal + CoA + NADP(+) = butanoyl-CoA + H(+) + NADPH"}
{"X":25799,"RHEA_ID":33592,"compounds":"sphinganine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoylsphinganine"}
{"X":25800,"RHEA_ID":22974,"compounds":"butanoyl-CoA + H(+) + NADPH => butanal + CoA + NADP(+)"}
{"X":25801,"RHEA_ID":33594,"compounds":"sphinganine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoylsphinganine"}
{"X":25802,"RHEA_ID":22976,"DIRECTION":"UN","MASTER_ID":22976,"ec":"6.2.1.7","compounds":"(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate"}
{"X":25803,"RHEA_ID":33596,"compounds":"4-hydroxysphinganine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoylphytosphingosine"}
{"X":25804,"RHEA_ID":22978,"compounds":"(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA"}
{"X":25805,"RHEA_ID":33598,"compounds":"4-hydroxysphinganine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoylphytosphingosine"}
{"X":25806,"RHEA_ID":22980,"DIRECTION":"UN","MASTER_ID":22980,"ec":"2.4.99.18","compounds":"a dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = dolichyl diphosphate + H(+) + N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein]"}
{"X":25807,"RHEA_ID":33600,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + N-hexacosanoylsphinganine + O2 => 2 [Fe(III)-cytochrome b5] + H2O + N-(hexacosanoyl)-(4R)-hydroxysphinganine"}
{"X":25808,"RHEA_ID":22982,"compounds":"dolichyl diphosphate + H(+) + N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] => a dolichyl diphosphooligosaccharide + L-asparaginyl-[protein]"}
{"X":25809,"RHEA_ID":22984,"DIRECTION":"UN","MASTER_ID":22984,"ec":"2.1.3.5","compounds":"carbamoyl phosphate + oxamate = N-carbamoyl-2-oxoglycine + phosphate"}
{"X":25810,"RHEA_ID":22985,"compounds":"carbamoyl phosphate + oxamate => N-carbamoyl-2-oxoglycine + phosphate"}
{"X":25811,"RHEA_ID":22986,"DIRECTION":"RL","MASTER_ID":22984,"ecocyc":"OXAMATE-CARBAMOYLTRANSFERASE-RXN","metacyc":"OXAMATE-CARBAMOYLTRANSFERASE-RXN","compounds":"N-carbamoyl-2-oxoglycine + phosphate => carbamoyl phosphate + oxamate"}
{"X":25812,"RHEA_ID":33606,"compounds":"H(+) + N-hexacosanoylsphinganine + NADPH + O2 <=> H2O + N-(2-hydroxyhexacosanoyl)sphinganine + NADP(+)"}
{"X":25813,"RHEA_ID":22988,"DIRECTION":"UN","MASTER_ID":22988,"ec":"1.2.1.18","compounds":"3-oxopropanoate + CoA + NADP(+) = acetyl-CoA + CO2 + NADPH"}
{"X":25814,"RHEA_ID":33608,"compounds":"(9Z)-octadecenoate + ATP + CoA => (9Z)-octadecenoyl-CoA + AMP + diphosphate"}
{"X":25815,"RHEA_ID":22990,"compounds":"acetyl-CoA + CO2 + NADPH => 3-oxopropanoate + CoA + NADP(+)"}
{"X":25816,"RHEA_ID":33610,"compounds":"(9Z)-octadecenoate + ATP + CoA <=> (9Z)-octadecenoyl-CoA + AMP + diphosphate"}
{"X":25817,"RHEA_ID":22992,"DIRECTION":"UN","MASTER_ID":22992,"ec":"1.2.1.18","compounds":"3-oxopropanoate + CoA + NAD(+) = acetyl-CoA + CO2 + NADH"}
{"X":25818,"RHEA_ID":33616,"compounds":"ATP + CoA + octadecanoate => AMP + diphosphate + octadecanoyl-CoA"}
{"X":25819,"RHEA_ID":22993,"DIRECTION":"LR","MASTER_ID":22992,"metacyc":"RXN-9958","compounds":"3-oxopropanoate + CoA + NAD(+) => acetyl-CoA + CO2 + NADH"}
{"X":25820,"RHEA_ID":22994,"compounds":"acetyl-CoA + CO2 + NADH => 3-oxopropanoate + CoA + NAD(+)"}
{"X":25821,"RHEA_ID":33619,"compounds":"ATP + CoA + tetradecanoate = AMP + diphosphate + tetradecanoyl-CoA"}
{"X":25822,"RHEA_ID":33620,"compounds":"ATP + CoA + tetradecanoate => AMP + diphosphate + tetradecanoyl-CoA"}
{"X":25823,"RHEA_ID":22997,"DIRECTION":"LR","MASTER_ID":22996,"ecocyc":"RXN-12440","metacyc":"RXN-12440","compounds":"H2O2 + L-ascorbate => 2 H2O + L-dehydroascorbate"}
{"X":25824,"RHEA_ID":22998,"compounds":"2 H2O + L-dehydroascorbate => H2O2 + L-ascorbate"}
{"X":25825,"RHEA_ID":33623,"compounds":"ATP + CoA + dodecanoate = AMP + diphosphate + dodecanoyl-CoA"}
{"X":25826,"RHEA_ID":33624,"compounds":"ATP + CoA + dodecanoate => AMP + diphosphate + dodecanoyl-CoA"}
{"X":25827,"RHEA_ID":23001,"compounds":"(R)-pantoate + NAD(+) => (R)-4-dehydropantoate + H(+) + NADH"}
{"X":25828,"RHEA_ID":23002,"compounds":"(R)-4-dehydropantoate + H(+) + NADH => (R)-pantoate + NAD(+)"}
{"X":25829,"RHEA_ID":33627,"compounds":"ATP + CoA + decanoate = AMP + decanoyl-CoA + diphosphate"}
{"X":25830,"RHEA_ID":23004,"compounds":"a neolactoside nLc4Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine = a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + H(+) + UDP"}
{"X":25831,"RHEA_ID":23005,"compounds":"a neolactoside nLc4Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine => a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + H(+) + UDP"}
{"X":25832,"RHEA_ID":23006,"compounds":"a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + H(+) + UDP => a neolactoside nLc4Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":25833,"RHEA_ID":33631,"compounds":"ATP + CoA + octanoate = AMP + diphosphate + octanoyl-CoA"}
{"X":25834,"RHEA_ID":33632,"compounds":"ATP + CoA + octanoate => AMP + diphosphate + octanoyl-CoA"}
{"X":25835,"RHEA_ID":23009,"DIRECTION":"LR","MASTER_ID":23008,"ecocyc":"TRE6PHYDRO-RXN","metacyc":"TRE6PHYDRO-RXN","compounds":"alpha,alpha-trehalose 6-phosphate + H2O => D-glucose + D-glucose 6-phosphate"}
{"X":25836,"RHEA_ID":23010,"compounds":"D-glucose + D-glucose 6-phosphate => alpha,alpha-trehalose 6-phosphate + H2O"}
{"X":25837,"RHEA_ID":33635,"compounds":"ATP + CoA + docosanoate = AMP + diphosphate + docosanoyl-CoA"}
{"X":25838,"RHEA_ID":23012,"DIRECTION":"UN","MASTER_ID":23012,"ec":"2.1.1.15","compounds":"a fatty acid + S-adenosyl-L-methionine = a fatty acid methyl ester + S-adenosyl-L-homocysteine"}
{"X":25839,"RHEA_ID":23013,"DIRECTION":"LR","MASTER_ID":23012,"metacyc":"FATTY-ACID-O-METHYLTRANSFERASE-RXN","compounds":"a fatty acid + S-adenosyl-L-methionine => a fatty acid methyl ester + S-adenosyl-L-homocysteine"}
{"X":25840,"RHEA_ID":23014,"compounds":"a fatty acid methyl ester + S-adenosyl-L-homocysteine => a fatty acid + S-adenosyl-L-methionine"}
{"X":25841,"RHEA_ID":33639,"compounds":"ATP + CoA + tetracosanoate = AMP + diphosphate + tetracosanoyl-CoA"}
{"X":25842,"RHEA_ID":33640,"compounds":"ATP + CoA + tetracosanoate => AMP + diphosphate + tetracosanoyl-CoA"}
{"X":25843,"RHEA_ID":23017,"compounds":"(2R,3S,4S)-3,4-leucopelargonidin + NADP(+) => (2R,3R)-dihydrokaempferol + H(+) + NADPH"}
{"X":25844,"RHEA_ID":23018,"DIRECTION":"RL","MASTER_ID":23016,"metacyc":"DIHYDROKAEMPFEROL-4-REDUCTASE-RXN","compounds":"(2R,3R)-dihydrokaempferol + H(+) + NADPH => (2R,3S,4S)-3,4-leucopelargonidin + NADP(+)"}
{"X":25845,"RHEA_ID":33643,"compounds":"(9Z)-tetradecenoate + ATP + CoA = (9Z)-tetradecenoyl-CoA + AMP + diphosphate"}
{"X":25846,"RHEA_ID":23024,"DIRECTION":"UN","MASTER_ID":23024,"ec":"2.4.1.49","metacyc":"CELLODEXTRIN-PHOSPHORYLASE-RXN","compounds":"[(1->4)-beta-D-glucosyl](n) + phosphate = [(1->4)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate"}
{"X":25847,"RHEA_ID":23025,"compounds":"[(1->4)-beta-D-glucosyl](n) + phosphate => [(1->4)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate"}
{"X":25848,"RHEA_ID":23026,"compounds":"[(1->4)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate => [(1->4)-beta-D-glucosyl](n) + phosphate"}
{"X":25849,"RHEA_ID":33648,"compounds":"(9Z)-hexadecenoate + ATP + CoA => (9Z)-hexadecenoyl-CoA + AMP + diphosphate"}
{"X":25850,"RHEA_ID":23029,"DIRECTION":"LR","MASTER_ID":23028,"metacyc":"RXN-9775","compounds":"malonyl-[ACP] + N(6)-biotinyl-L-lysyl-[protein] => acetyl-[ACP] + N(6)-carboxybiotinyl-L-lysyl-[protein]"}
{"X":25851,"RHEA_ID":23030,"compounds":"acetyl-[ACP] + N(6)-carboxybiotinyl-L-lysyl-[protein] => malonyl-[ACP] + N(6)-biotinyl-L-lysyl-[protein]"}
{"X":25852,"RHEA_ID":33652,"compounds":"(9Z,12Z)-octadecadienoate + ATP + CoA => (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate"}
{"X":25853,"RHEA_ID":23033,"DIRECTION":"LR","MASTER_ID":23032,"ecocyc":"AIRS-RXN","metacyc":"AIRS-RXN","compounds":"2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate"}
{"X":25854,"RHEA_ID":23034,"compounds":"5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate => 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP"}
{"X":25855,"RHEA_ID":33655,"compounds":"(9Z)-octadecenoate(out) = (9Z)-octadecenoate(in)"}
{"X":25856,"RHEA_ID":33656,"compounds":"(9Z)-octadecenoate(out) => (9Z)-octadecenoate(in)"}
{"X":25857,"RHEA_ID":23037,"compounds":"2 inosine + O2 => 2 5'-dehydroinosine + 2 H2O"}
{"X":25858,"RHEA_ID":23038,"compounds":"2 5'-dehydroinosine + 2 H2O => 2 inosine + O2"}
{"X":25859,"RHEA_ID":33659,"compounds":"H(+) + N-tetracosanoylsphinganine + NADPH + O2 = H2O + N-(2-hydroxytetracosanoyl)sphinganine + NADP(+)"}
{"X":25860,"RHEA_ID":23040,"DIRECTION":"UN","MASTER_ID":23040,"ec":"2.3.3.6","metacyc":"2-ETHYLMALATE-SYNTHASE-RXN","compounds":"2-oxobutanoate + acetyl-CoA + H2O = (R)-2-ethylmalate + CoA + H(+)"}
{"X":25861,"RHEA_ID":23041,"compounds":"2-oxobutanoate + acetyl-CoA + H2O => (R)-2-ethylmalate + CoA + H(+)"}
{"X":25862,"RHEA_ID":23042,"compounds":"(R)-2-ethylmalate + CoA + H(+) => 2-oxobutanoate + acetyl-CoA + H2O"}
{"X":25863,"RHEA_ID":33663,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + N-(hexacosanoyl)-(4R)-hydroxysphinganine + O2 = 2 [Fe(III)-cytochrome b5] + H2O + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine"}
{"X":25864,"RHEA_ID":23044,"compounds":"H(+) + N,N-dihydroxy-L-tyrosine = (E)-4-hydroxyphenylacetaldehyde oxime + CO2 + H2O"}
{"X":25865,"RHEA_ID":23045,"DIRECTION":"LR","MASTER_ID":23044,"metacyc":"RXN-7749","compounds":"H(+) + N,N-dihydroxy-L-tyrosine => (E)-4-hydroxyphenylacetaldehyde oxime + CO2 + H2O"}
{"X":25866,"RHEA_ID":23046,"compounds":"(E)-4-hydroxyphenylacetaldehyde oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-tyrosine"}
{"X":25867,"RHEA_ID":33667,"compounds":"H(+) + N-tetracosanoylphytosphingosine + NADPH + O2 = H2O + N-(2-hydroxytetracosanoyl)phytosphingosine + NADP(+)"}
{"X":25868,"RHEA_ID":23048,"DIRECTION":"UN","MASTER_ID":23048,"ec":"1.1.99.24","compounds":"(S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate"}
{"X":25869,"RHEA_ID":23049,"compounds":"(S)-3-hydroxybutanoate + 2-oxoglutarate => (R)-2-hydroxyglutarate + acetoacetate"}
{"X":25870,"RHEA_ID":33670,"compounds":"H(+) + N-tetracosanoylphytosphingosine + NADPH + O2 <=> H2O + N-(2-hydroxytetracosanoyl)phytosphingosine + NADP(+)"}
{"X":25871,"RHEA_ID":33671,"compounds":"2 [Fe(III)-cytochrome b5] + H2O + N-(2,3-dihydroxyhexacosanoyl)-(4S)-hydroxysphinganine = 2 [Fe(II)-cytochrome b5] + 2 H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine + O2"}
{"X":25872,"RHEA_ID":23052,"DIRECTION":"UN","MASTER_ID":23052,"ec":"2.7.11.2","compounds":"[pyruvate dehydrogenase E1 alpha subunit]-L-serine + ATP = [pyruvate dehydrogenase E1 alpha subunit]-O-phospho-L-serine + ADP + H(+)"}
{"X":25873,"RHEA_ID":23053,"DIRECTION":"LR","MASTER_ID":23052,"metacyc":"2.7.11.2-RXN","compounds":"[pyruvate dehydrogenase E1 alpha subunit]-L-serine + ATP => [pyruvate dehydrogenase E1 alpha subunit]-O-phospho-L-serine + ADP + H(+)"}
{"X":25874,"RHEA_ID":23054,"compounds":"[pyruvate dehydrogenase E1 alpha subunit]-O-phospho-L-serine + ADP + H(+) => [pyruvate dehydrogenase E1 alpha subunit]-L-serine + ATP"}
{"X":25875,"RHEA_ID":33675,"compounds":"(4S)-N-(2,3-dihydroxytetracosanoyl)-4-hydroxysphinganine + H2O + NADP(+) = H(+) + N-(2-hydroxytetracosanoyl)phytosphingosine + NADPH + O2"}
{"X":25876,"RHEA_ID":33676,"compounds":"(4S)-N-(2,3-dihydroxytetracosanoyl)-4-hydroxysphinganine + H2O + NADP(+) => H(+) + N-(2-hydroxytetracosanoyl)phytosphingosine + NADPH + O2"}
{"X":25877,"RHEA_ID":23057,"compounds":"urea => cyanamide + H2O"}
{"X":25878,"RHEA_ID":23058,"compounds":"cyanamide + H2O => urea"}
{"X":25879,"RHEA_ID":33680,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + N-tetracosanoylsphinganine + O2 => 2 [Fe(III)-cytochrome b5] + H2O + N-tetracosanoylphytosphingosine"}
{"X":25880,"RHEA_ID":23061,"DIRECTION":"LR","MASTER_ID":23060,"metacyc":"RXN-18557","compounds":"a (2R,3S)-2-alkyl-3-hydroxyalkanoate + ATP => a cis-3-alkyl-4-alkyloxetan-2-one + AMP + diphosphate"}
{"X":25881,"RHEA_ID":23062,"compounds":"a cis-3-alkyl-4-alkyloxetan-2-one + AMP + diphosphate => a (2R,3S)-2-alkyl-3-hydroxyalkanoate + ATP"}
{"X":25882,"RHEA_ID":33683,"compounds":"H(+) + L-serine + octadecanoyl-CoA = 3-oxoeicosasphinganine + CO2 + CoA"}
{"X":25883,"RHEA_ID":23064,"DIRECTION":"UN","MASTER_ID":23064,"ec":"1.14.14.5","compounds":"an alkanesulfonate + FMNH2 + O2 = an aldehyde + FMN + 2 H(+) + H2O + sulfite"}
{"X":25884,"RHEA_ID":33685,"compounds":"3-oxoeicosasphinganine + CO2 + CoA => H(+) + L-serine + octadecanoyl-CoA"}
{"X":25885,"RHEA_ID":23066,"compounds":"an aldehyde + FMN + 2 H(+) + H2O + sulfite => an alkanesulfonate + FMNH2 + O2"}
{"X":25886,"RHEA_ID":33687,"compounds":"3'-N-debenzoyltaxol + benzoyl-CoA = CoA + H(+) + taxol"}
{"X":25887,"RHEA_ID":23068,"DIRECTION":"UN","MASTER_ID":23068,"ec":"2.3.1.94","compounds":"6 (S)-methylmalonyl-CoA + 12 H(+) + 6 NADPH + propanoyl-CoA = 6-deoxyerythronolide B + 6 CO2 + 7 CoA + H2O + 6 NADP(+)"}
{"X":25888,"RHEA_ID":33689,"compounds":"CoA + H(+) + taxol => 3'-N-debenzoyltaxol + benzoyl-CoA"}
{"X":25889,"RHEA_ID":23070,"compounds":"6-deoxyerythronolide B + 6 CO2 + 7 CoA + H2O + 6 NADP(+) => 6 (S)-methylmalonyl-CoA + 12 H(+) + 6 NADPH + propanoyl-CoA"}
{"X":25890,"RHEA_ID":33691,"compounds":"2-(1-hydroxyethyl)thiamine diphosphate + 2-oxobutanoate = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + thiamine diphosphate"}
{"X":25891,"RHEA_ID":23072,"compounds":"H(+) + oxaloacetate + phosphate = CO2 + H2O + phosphoenolpyruvate"}
{"X":25892,"RHEA_ID":33693,"compounds":"(S)-2-ethyl-2-hydroxy-3-oxobutanoate + thiamine diphosphate => 2-(1-hydroxyethyl)thiamine diphosphate + 2-oxobutanoate"}
{"X":25893,"RHEA_ID":23074,"compounds":"CO2 + H2O + phosphoenolpyruvate => H(+) + oxaloacetate + phosphate"}
{"X":25894,"RHEA_ID":33695,"compounds":"C20 sphinganine + NADP(+) = 3-oxoeicosasphinganine + H(+) + NADPH"}
{"X":25895,"RHEA_ID":23076,"DIRECTION":"UN","MASTER_ID":23076,"ec":"1.21.1.2","compounds":"4-chlorobenzoyl-CoA + chloride + NADP(+) = 2,4-dichlorobenzoyl-CoA + NADPH"}
{"X":25896,"RHEA_ID":33697,"compounds":"3-oxoeicosasphinganine + H(+) + NADPH => C20 sphinganine + NADP(+)"}
{"X":25897,"RHEA_ID":23078,"DIRECTION":"RL","MASTER_ID":23076,"metacyc":"1.3.1.63-RXN","compounds":"2,4-dichlorobenzoyl-CoA + NADPH => 4-chlorobenzoyl-CoA + chloride + NADP(+)"}
{"X":25898,"RHEA_ID":33699,"compounds":"2 [Fe(II)-cytochrome b5] + C20 sphinganine + 2 H(+) + O2 = (4R)-hydroxyeicosasphinganine + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":25899,"RHEA_ID":23080,"DIRECTION":"UN","MASTER_ID":23080,"ec":"4.2.1.90","compounds":"L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H2O"}
{"X":25900,"RHEA_ID":33701,"compounds":"(4R)-hydroxyeicosasphinganine + 2 [Fe(III)-cytochrome b5] + H2O => 2 [Fe(II)-cytochrome b5] + C20 sphinganine + 2 H(+) + O2"}
{"X":25901,"RHEA_ID":23082,"compounds":"2-dehydro-3-deoxy-L-rhamnonate + H2O => L-rhamnonate"}
{"X":25902,"RHEA_ID":33703,"compounds":"(4R)-hydroxyeicosasphinganine + hexacosanoyl-CoA = CoA + H(+) + N-hexacosanoyl-C20-4-hydroxysphinganine"}
{"X":25903,"RHEA_ID":23084,"DIRECTION":"UN","MASTER_ID":23084,"ec":"4.1.3.26","compounds":"3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 7-methyl-3-oxooct-6-enoyl-CoA + acetate"}
{"X":25904,"RHEA_ID":23085,"DIRECTION":"LR","MASTER_ID":23084,"metacyc":"4.1.3.26-RXN","compounds":"3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA => 7-methyl-3-oxooct-6-enoyl-CoA + acetate"}
{"X":25905,"RHEA_ID":33706,"compounds":"(4R)-hydroxyeicosasphinganine + hexacosanoyl-CoA <=> CoA + H(+) + N-hexacosanoyl-C20-4-hydroxysphinganine"}
{"X":25906,"RHEA_ID":33707,"DIRECTION":"UN","MASTER_ID":33707,"ec":"2.7.1.177","compounds":"ATP + L-threonine = ADP + H(+) + O-phospho-L-threonine"}
{"X":25907,"RHEA_ID":23088,"DIRECTION":"UN","MASTER_ID":23088,"ec":"2.7.1.84","metacyc":"ALKYLGLYCERONE-KINASE-RXN","compounds":"ATP + O-alkylglycerone = 1-O-alkylglycerone 3-phosphate + ADP + H(+)"}
{"X":25908,"RHEA_ID":23089,"compounds":"ATP + O-alkylglycerone => 1-O-alkylglycerone 3-phosphate + ADP + H(+)"}
{"X":25909,"RHEA_ID":43641,"compounds":"dodecanoyl-CoA + H(+) + malonyl-[ACP] => 3-oxotetradecanoyl-[ACP] + CO2 + CoA"}
{"X":25910,"RHEA_ID":33711,"DIRECTION":"UN","MASTER_ID":33711,"ec":"3.1.1.92","compounds":"4-sulfomuconolactone + H2O = 2 H(+) + maleylacetate + sulfite"}
{"X":25911,"RHEA_ID":23092,"DIRECTION":"UN","MASTER_ID":23092,"ec":"3.5.4.43","compounds":"H(+) + H2O + hydroxyatrazine = ethylamine + N-isopropylammelide"}
{"X":25912,"RHEA_ID":23093,"DIRECTION":"LR","MASTER_ID":23092,"metacyc":"R122-RXN","compounds":"H(+) + H2O + hydroxyatrazine => ethylamine + N-isopropylammelide"}
{"X":25913,"RHEA_ID":43645,"compounds":"H(+) + malonyl-[ACP] + tetradecanoyl-CoA => 3-oxohexadecanoyl-[ACP] + CO2 + CoA"}
{"X":25914,"RHEA_ID":33715,"compounds":"4-hydroxyeicosasphinganine 1-phosphate = 2-hydroxyoctadecanal + phosphoethanolamine"}
{"X":25915,"RHEA_ID":23096,"DIRECTION":"UN","MASTER_ID":23096,"ec":"2.7.1.49","compounds":"4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+)"}
{"X":25916,"RHEA_ID":23097,"DIRECTION":"LR","MASTER_ID":23096,"ecocyc":"OHMETPYRKIN-RXN","metacyc":"OHMETPYRKIN-RXN","compounds":"4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP => 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+)"}
{"X":25917,"RHEA_ID":23098,"compounds":"4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+) => 4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP"}
{"X":25918,"RHEA_ID":33719,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-hexacosanoylsphinganine = a 1,2-diacyl-sn-glycerol + N-(hexacosanoyl)-sphinganine-1-(1D-myo-inositol)"}
{"X":25919,"RHEA_ID":23100,"DIRECTION":"UN","MASTER_ID":23100,"ec":"2.7.4.11","compounds":"ATP + dAMP = ADP + dADP"}
{"X":25920,"RHEA_ID":23101,"DIRECTION":"LR","MASTER_ID":23100,"metacyc":"DEOXYADENYLATE-KINASE-RXN","reactome":"R-HSA-74220.5","compounds":"ATP + dAMP => ADP + dADP"}
{"X":25921,"RHEA_ID":33722,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-hexacosanoylsphinganine <=> a 1,2-diacyl-sn-glycerol + N-(hexacosanoyl)-sphinganine-1-(1D-myo-inositol)"}
{"X":25922,"RHEA_ID":33723,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-tetracosanoylsphinganine = a 1,2-diacyl-sn-glycerol + N-tetracosanoylsphinganine-(1D-myo-inositol)"}
{"X":25923,"RHEA_ID":23104,"DIRECTION":"UN","MASTER_ID":23104,"ec":"5.3.1.13","compounds":"D-arabinose 5-phosphate = D-ribulose 5-phosphate"}
{"X":25924,"RHEA_ID":23105,"compounds":"D-arabinose 5-phosphate => D-ribulose 5-phosphate"}
{"X":25925,"RHEA_ID":33726,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-tetracosanoylsphinganine <=> a 1,2-diacyl-sn-glycerol + N-tetracosanoylsphinganine-(1D-myo-inositol)"}
{"X":25926,"RHEA_ID":33727,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-(2-hydroxyhexacosanoyl)sphinganine = a 1,2-diacyl-sn-glycerol + Ins-1-P-Cer(d18:0/2-OH-26:0)"}
{"X":25927,"RHEA_ID":23108,"DIRECTION":"UN","MASTER_ID":23108,"ec":"3.1.1.30","compounds":"D-arabinono-1,4-lactone + H2O = D-arabinonate + H(+)"}
{"X":25928,"RHEA_ID":23109,"DIRECTION":"LR","MASTER_ID":23108,"metacyc":"D-ARABINONOLACTONASE-RXN","compounds":"D-arabinono-1,4-lactone + H2O => D-arabinonate + H(+)"}
{"X":25929,"RHEA_ID":33730,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-(2-hydroxyhexacosanoyl)sphinganine <=> a 1,2-diacyl-sn-glycerol + Ins-1-P-Cer(d18:0/2-OH-26:0)"}
{"X":25930,"RHEA_ID":33731,"compounds":"1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a 1-acyl-sn-glycero-3-phosphocholine + a cardiolipin"}
{"X":25931,"RHEA_ID":23112,"DIRECTION":"UN","MASTER_ID":23112,"ec":"4.1.1.52","compounds":"6-methylsalicylate + H(+) = 3-methylphenol + CO2"}
{"X":25932,"RHEA_ID":23113,"DIRECTION":"LR","MASTER_ID":23112,"metacyc":"6-METHYLSALICYLATE-DECARBOXYLASE-RXN","compounds":"6-methylsalicylate + H(+) => 3-methylphenol + CO2"}
{"X":25933,"RHEA_ID":33734,"compounds":"1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine <=> a 1-acyl-sn-glycero-3-phosphocholine + a cardiolipin"}
{"X":25934,"RHEA_ID":33739,"compounds":"2 H(+) + hexadecanoate + NADH = H2O + hexadecanal + NAD(+)"}
{"X":25935,"RHEA_ID":23116,"DIRECTION":"UN","MASTER_ID":23116,"ec":"6.2.1.27","compounds":"4-hydroxybenzoate + ATP + CoA = 4-hydroxybenzoyl-CoA + AMP + diphosphate"}
{"X":25936,"RHEA_ID":23117,"compounds":"4-hydroxybenzoate + ATP + CoA => 4-hydroxybenzoyl-CoA + AMP + diphosphate"}
{"X":25937,"RHEA_ID":33742,"compounds":"2 H(+) + hexadecanoate + NADH <=> H2O + hexadecanal + NAD(+)"}
{"X":25938,"RHEA_ID":33743,"compounds":"H2O + N-acylsphing-4-enine 1-phosphate = an N-acylsphing-4-enine + phosphate"}
{"X":25939,"RHEA_ID":23120,"DIRECTION":"UN","MASTER_ID":23120,"ec":"7.4.2.9","compounds":"a dipeptide(out) + ATP + H2O = a dipeptide(in) + ADP + H(+) + phosphate"}
{"X":25940,"RHEA_ID":23121,"DIRECTION":"LR","MASTER_ID":23120,"ecocyc":"ABC-8-RXN","metacyc":"ABC-8-RXN","compounds":"a dipeptide(out) + ATP + H2O => a dipeptide(in) + ADP + H(+) + phosphate"}
{"X":25941,"RHEA_ID":33746,"compounds":"H2O + N-acylsphing-4-enine 1-phosphate <=> an N-acylsphing-4-enine + phosphate"}
{"X":25942,"RHEA_ID":23123,"compounds":"a dipeptide(out) + ATP + H2O <=> a dipeptide(in) + ADP + H(+) + phosphate"}
{"X":25943,"RHEA_ID":23124,"DIRECTION":"UN","MASTER_ID":23124,"ec":"4.1.1.39","compounds":"2 (2R)-3-phosphoglycerate + 2 H(+) = CO2 + D-ribulose 1,5-bisphosphate + H2O"}
{"X":25944,"RHEA_ID":23125,"compounds":"2 (2R)-3-phosphoglycerate + 2 H(+) => CO2 + D-ribulose 1,5-bisphosphate + H2O"}
{"X":25945,"RHEA_ID":23126,"DIRECTION":"RL","MASTER_ID":23124,"metacyc":"RIBULOSE-BISPHOSPHATE-CARBOXYLASE-RXN","compounds":"CO2 + D-ribulose 1,5-bisphosphate + H2O => 2 (2R)-3-phosphoglycerate + 2 H(+)"}
{"X":25946,"RHEA_ID":33751,"DIRECTION":"UN","MASTER_ID":33751,"ec":"3.1.3.27","compounds":"1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate"}
{"X":25947,"RHEA_ID":23128,"DIRECTION":"UN","MASTER_ID":23128,"ec":"6.2.1.40","compounds":"4-hydroxybutanoate + ATP + CoA = 4-hydroxybutanoyl-CoA + AMP + diphosphate"}
{"X":25948,"RHEA_ID":23129,"DIRECTION":"LR","MASTER_ID":23128,"metacyc":"RXN-9092","compounds":"4-hydroxybutanoate + ATP + CoA => 4-hydroxybutanoyl-CoA + AMP + diphosphate"}
{"X":25949,"RHEA_ID":23130,"compounds":"4-hydroxybutanoyl-CoA + AMP + diphosphate => 4-hydroxybutanoate + ATP + CoA"}
{"X":25950,"RHEA_ID":33755,"compounds":"H2O + N-hexadecanoyl-4-hydroxysphinganine = 4-hydroxysphinganine + hexadecanoate"}
{"X":25951,"RHEA_ID":23132,"DIRECTION":"UN","MASTER_ID":23132,"ec":"1.8.7.1","compounds":"3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] = 7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite"}
{"X":25952,"RHEA_ID":23133,"compounds":"3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] => 7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite"}
{"X":25953,"RHEA_ID":33758,"compounds":"H2O + N-hexadecanoyl-4-hydroxysphinganine <=> 4-hydroxysphinganine + hexadecanoate"}
{"X":25954,"RHEA_ID":23136,"DIRECTION":"UN","MASTER_ID":23136,"ec":"2.1.1.49","compounds":"a primary amine + S-adenosyl-L-methionine = a methylated primary amine + H(+) + S-adenosyl-L-homocysteine"}
{"X":25955,"RHEA_ID":23137,"DIRECTION":"LR","MASTER_ID":23136,"metacyc":"AMINE-N-METHYLTRANSFERASE-RXN","compounds":"a primary amine + S-adenosyl-L-methionine => a methylated primary amine + H(+) + S-adenosyl-L-homocysteine"}
{"X":25956,"RHEA_ID":33762,"compounds":"3-oxo-fatty acyl-CoA + H(+) + NADPH <=> a 3-hydroxyacyl-CoA + NADP(+)"}
{"X":25957,"RHEA_ID":33763,"DIRECTION":"UN","MASTER_ID":33763,"ec":"1.3.1.38","compounds":"a (2E)-enoyl-CoA + H(+) + NADPH = a 2,3-saturated acyl-CoA + NADP(+)"}
{"X":25958,"RHEA_ID":23140,"DIRECTION":"UN","MASTER_ID":23140,"ec":"3.2.2.14","compounds":"beta-nicotinamide D-ribonucleotide + H2O = D-ribose 5-phosphate + H(+) + nicotinamide"}
{"X":25959,"RHEA_ID":23141,"DIRECTION":"LR","MASTER_ID":23140,"ecocyc":"NMNNUCLEOSID-RXN","metacyc":"NMNNUCLEOSID-RXN","compounds":"beta-nicotinamide D-ribonucleotide + H2O => D-ribose 5-phosphate + H(+) + nicotinamide"}
{"X":25960,"RHEA_ID":23142,"compounds":"D-ribose 5-phosphate + H(+) + nicotinamide => beta-nicotinamide D-ribonucleotide + H2O"}
{"X":25961,"RHEA_ID":33767,"compounds":"a 3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O"}
{"X":25962,"RHEA_ID":23144,"DIRECTION":"UN","MASTER_ID":23144,"ec":"1.1.1.240","metacyc":"N-ACETYLHEXOSAMINE-1-DEHYDROGENASE-RXN","compounds":"H2O + N-acetyl-alpha-D-glucosamine + NAD(+) = 2 H(+) + N-acetyl-D-glucosaminate + NADH"}
{"X":25963,"RHEA_ID":23145,"compounds":"H2O + N-acetyl-alpha-D-glucosamine + NAD(+) => 2 H(+) + N-acetyl-D-glucosaminate + NADH"}
{"X":25964,"RHEA_ID":33770,"compounds":"a 3-hydroxyacyl-CoA <=> a (2E)-enoyl-CoA + H2O"}
{"X":25965,"RHEA_ID":33771,"compounds":"a 1,2-diacyl-sn-glycerol + CDP-N-methylethanolamine = 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + CMP + H(+)"}
{"X":25966,"RHEA_ID":23148,"DIRECTION":"UN","MASTER_ID":23148,"ec":"2.7.2.15","compounds":"ATP + propanoate = ADP + propanoyl phosphate"}
{"X":25967,"RHEA_ID":23149,"compounds":"ATP + propanoate => ADP + propanoyl phosphate"}
{"X":25968,"RHEA_ID":33774,"compounds":"a 1,2-diacyl-sn-glycerol + CDP-N-methylethanolamine <=> 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + CMP + H(+)"}
{"X":25969,"RHEA_ID":33775,"compounds":"a 1,2-diacyl-sn-glycerol + CDP-N,N-dimethylethanolamine = 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+)"}
{"X":25970,"RHEA_ID":33776,"compounds":"a 1,2-diacyl-sn-glycerol + CDP-N,N-dimethylethanolamine => 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+)"}
{"X":25971,"RHEA_ID":23152,"DIRECTION":"UN","MASTER_ID":23152,"ec":"1.6.5.9","compounds":"a ubiquinone + H(+) + NADH = a ubiquinol + NAD(+)"}
{"X":25972,"RHEA_ID":33778,"compounds":"a 1,2-diacyl-sn-glycerol + CDP-N,N-dimethylethanolamine <=> 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+)"}
{"X":25973,"RHEA_ID":23154,"compounds":"a ubiquinol + NAD(+) => a ubiquinone + H(+) + NADH"}
{"X":25974,"RHEA_ID":23156,"DIRECTION":"UN","MASTER_ID":23156,"ec":"4.99.1.6","compounds":"(E)-(indol-3-yl)acetaldehyde oxime = (indol-3-yl)acetonitrile + H2O"}
{"X":25975,"RHEA_ID":33782,"DIRECTION":"BI","MASTER_ID":33779,"metacyc":"RXN-9068","compounds":"6-kestotriose + sucrose <=> 6,6-kestotetraose + beta-D-glucose"}
{"X":25976,"RHEA_ID":23158,"compounds":"(indol-3-yl)acetonitrile + H2O => (E)-(indol-3-yl)acetaldehyde oxime"}
{"X":25977,"RHEA_ID":33784,"DIRECTION":"LR","MASTER_ID":33783,"metacyc":"RXN-1804","compounds":"1(F)-beta-D-fructosylsucrose + sucrose => 1,6-kestotetraose + beta-D-glucose"}
{"X":25978,"RHEA_ID":23160,"DIRECTION":"UN","MASTER_ID":23160,"ec":"5.3.1.14","compounds":"L-rhamnopyranose = L-rhamnulose"}
{"X":25979,"RHEA_ID":33786,"compounds":"1(F)-beta-D-fructosylsucrose + sucrose <=> 1,6-kestotetraose + beta-D-glucose"}
{"X":25980,"RHEA_ID":23162,"compounds":"L-rhamnulose => L-rhamnopyranose"}
{"X":25981,"RHEA_ID":33788,"DIRECTION":"LR","MASTER_ID":33787,"metacyc":"KETOLACTOSE-RXN","compounds":"3'-ketolactose + H2O => 3-keto-beta-D-galactose + beta-D-glucose"}
{"X":25982,"RHEA_ID":23164,"DIRECTION":"UN","MASTER_ID":23164,"ec":"2.4.1.237","compounds":"a 7-O-hydroxy-flavonol + UDP-alpha-D-glucose = a flavonol 7-O-beta-D-glucoside + H(+) + UDP"}
{"X":25983,"RHEA_ID":33790,"compounds":"3'-ketolactose + H2O <=> 3-keto-beta-D-galactose + beta-D-glucose"}
{"X":25984,"RHEA_ID":23166,"compounds":"a flavonol 7-O-beta-D-glucoside + H(+) + UDP => a 7-O-hydroxy-flavonol + UDP-alpha-D-glucose"}
{"X":25985,"RHEA_ID":33792,"DIRECTION":"LR","MASTER_ID":33791,"metacyc":"3.2.1.26-RXN","compounds":"H2O + sucrose 6(F)-phosphate => beta-D-fructose + beta-D-glucose 6-phosphate"}
{"X":25986,"RHEA_ID":23168,"DIRECTION":"UN","MASTER_ID":23168,"ec":"1.1.1.235","metacyc":"8-OXOCOFORMYCIN-REDUCTASE-RXN","compounds":"coformycin + NADP(+) = 8-oxocoformycin + H(+) + NADPH"}
{"X":25987,"RHEA_ID":33794,"compounds":"H2O + sucrose 6(F)-phosphate <=> beta-D-fructose + beta-D-glucose 6-phosphate"}
{"X":25988,"RHEA_ID":23170,"compounds":"8-oxocoformycin + H(+) + NADPH => coformycin + NADP(+)"}
{"X":25989,"RHEA_ID":33796,"DIRECTION":"LR","MASTER_ID":33795,"metacyc":"RXN-1461","compounds":"H2O + sucrose => alpha-D-glucose + beta-D-fructose"}
{"X":25990,"RHEA_ID":23172,"DIRECTION":"UN","MASTER_ID":23172,"ec":"2.7.11.31","compounds":"[3-hydroxy-3-methylglutaryl-coenzyme A reductase]-L-serine + ATP = [3-hydroxy-3-methylglutaryl-coenzyme A reductase]-O-phospho-L-serine + ADP + H(+)"}
{"X":25991,"RHEA_ID":23173,"compounds":"[3-hydroxy-3-methylglutaryl-coenzyme A reductase]-L-serine + ATP => [3-hydroxy-3-methylglutaryl-coenzyme A reductase]-O-phospho-L-serine + ADP + H(+)"}
{"X":25992,"RHEA_ID":23174,"compounds":"[3-hydroxy-3-methylglutaryl-coenzyme A reductase]-O-phospho-L-serine + ADP + H(+) => [3-hydroxy-3-methylglutaryl-coenzyme A reductase]-L-serine + ATP"}
{"X":25993,"RHEA_ID":33800,"DIRECTION":"LR","MASTER_ID":33799,"metacyc":"HISTOLDEHYD-RXN","compounds":"L-histidinol + NAD(+) => H(+) + L-histidinal + NADH"}
{"X":25994,"RHEA_ID":23176,"DIRECTION":"UN","MASTER_ID":23176,"ec":"6.2.1.1","compounds":"acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate"}
{"X":25995,"RHEA_ID":43729,"DIRECTION":"LR","MASTER_ID":43728,"metacyc":"RXN-11621","compounds":"methyl (2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + juvenile hormone III + oxidized [NADPH--hemoprotein reductase]"}
{"X":25996,"RHEA_ID":23177,"DIRECTION":"LR","MASTER_ID":23176,"ecocyc":"ACETATE--COA-LIGASE-RXN","reactome":"R-HSA-8875071.1","compounds":"acetate + ATP + CoA => acetyl-CoA + AMP + diphosphate"}
{"X":25997,"RHEA_ID":23177,"DIRECTION":"LR","MASTER_ID":23176,"ecocyc":"ACETATE--COA-LIGASE-RXN","reactome":"R-HSA-449911.2","compounds":"acetate + ATP + CoA => acetyl-CoA + AMP + diphosphate"}
{"X":25998,"RHEA_ID":23178,"compounds":"acetyl-CoA + AMP + diphosphate => acetate + ATP + CoA"}
{"X":25999,"RHEA_ID":53724,"DIRECTION":"UN","MASTER_ID":53724,"ec":"2.7.1.162","compounds":"ATP + N-acetyl-D-glucosamine = ADP + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate"}
{"X":26000,"RHEA_ID":23180,"DIRECTION":"UN","MASTER_ID":23180,"ec":"1.1.3.18","compounds":"a secondary alcohol + O2 = a ketone + H2O2"}
{"X":26001,"RHEA_ID":23181,"DIRECTION":"LR","MASTER_ID":23180,"metacyc":"SECONDARY-ALCOHOL-OXIDASE-RXN","compounds":"a secondary alcohol + O2 => a ketone + H2O2"}
{"X":26002,"RHEA_ID":23182,"compounds":"a ketone + H2O2 => a secondary alcohol + O2"}
{"X":26003,"RHEA_ID":23184,"DIRECTION":"UN","MASTER_ID":23184,"ec":"2.5.1.36","compounds":"(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate = (6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate"}
{"X":26004,"RHEA_ID":23185,"DIRECTION":"LR","MASTER_ID":23184,"metacyc":"RXN-4509","compounds":"(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate => (6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate"}
{"X":26005,"RHEA_ID":23186,"compounds":"(6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate => (6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate"}
{"X":26006,"RHEA_ID":43741,"compounds":"ATP + CoA + hexanoate => AMP + diphosphate + hexanoyl-CoA"}
{"X":26007,"RHEA_ID":23188,"DIRECTION":"UN","MASTER_ID":23188,"ec":"1.1.1.202","compounds":"NAD(+) + propane-1,3-diol = 3-hydroxypropanal + H(+) + NADH"}
{"X":26008,"RHEA_ID":23189,"compounds":"NAD(+) + propane-1,3-diol => 3-hydroxypropanal + H(+) + NADH"}
{"X":26009,"RHEA_ID":23190,"compounds":"3-hydroxypropanal + H(+) + NADH => NAD(+) + propane-1,3-diol"}
{"X":26010,"RHEA_ID":23192,"DIRECTION":"UN","MASTER_ID":23192,"ec":"2.4.1.227","compounds":"Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + UDP-N-acetyl-alpha-D-glucosamine = beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + H(+) + UDP"}
{"X":26011,"RHEA_ID":23193,"DIRECTION":"LR","MASTER_ID":23192,"metacyc":"RXN-8976","compounds":"Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + UDP-N-acetyl-alpha-D-glucosamine => beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + H(+) + UDP"}
{"X":26012,"RHEA_ID":23194,"compounds":"beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + H(+) + UDP => Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":26013,"RHEA_ID":53740,"compounds":"[Rab1 protein]-O(4)-(5'-adenylyl)-L-tyrosine + H2O = [Rab1 protein]-L-tyrosine + AMP + H(+)"}
{"X":26014,"RHEA_ID":23196,"DIRECTION":"UN","MASTER_ID":23196,"ec":"6.3.2.26","compounds":"3 ATP + H2O + L-2-aminoadipate + L-cysteine + L-valine = 3 AMP + 3 diphosphate + 3 H(+) + N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine"}
{"X":26015,"RHEA_ID":23197,"DIRECTION":"LR","MASTER_ID":23196,"metacyc":"6.3.2.26-RXN","compounds":"3 ATP + H2O + L-2-aminoadipate + L-cysteine + L-valine => 3 AMP + 3 diphosphate + 3 H(+) + N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine"}
{"X":26016,"RHEA_ID":23198,"compounds":"3 AMP + 3 diphosphate + 3 H(+) + N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine => 3 ATP + H2O + L-2-aminoadipate + L-cysteine + L-valine"}
{"X":26017,"RHEA_ID":43753,"DIRECTION":"LR","MASTER_ID":43752,"ecocyc":"RXN-18434","metacyc":"RXN-18434","compounds":"acetyl-CoA + N-terminal L-alanyl-[ribosomal protein uS5] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein uS5]"}
{"X":26018,"RHEA_ID":23200,"DIRECTION":"UN","MASTER_ID":23200,"ec":"1.5.3.4","compounds":"H2O + N(6)-methyl-L-lysine + O2 = formaldehyde + H2O2 + L-lysine"}
{"X":26019,"RHEA_ID":23201,"DIRECTION":"LR","MASTER_ID":23200,"metacyc":"N6-METHYL-LYSINE-OXIDASE-RXN","compounds":"H2O + N(6)-methyl-L-lysine + O2 => formaldehyde + H2O2 + L-lysine"}
{"X":26020,"RHEA_ID":23202,"compounds":"formaldehyde + H2O2 + L-lysine => H2O + N(6)-methyl-L-lysine + O2"}
{"X":26021,"RHEA_ID":43757,"DIRECTION":"LR","MASTER_ID":43756,"ecocyc":"2.3.1.128-RXN","metacyc":"2.3.1.128-RXN","compounds":"acetyl-CoA + N-terminal L-alanyl-[ribosomal protein bS18] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein bS18]"}
{"X":26022,"RHEA_ID":23204,"DIRECTION":"UN","MASTER_ID":23204,"ec":"2.3.1.98","compounds":"chlorogenate + D-glucarate = 2-O-caffeoylglucarate + L-quinate"}
{"X":26023,"RHEA_ID":23205,"DIRECTION":"LR","MASTER_ID":23204,"metacyc":"2.3.1.98-RXN","compounds":"chlorogenate + D-glucarate => 2-O-caffeoylglucarate + L-quinate"}
{"X":26024,"RHEA_ID":23206,"compounds":"2-O-caffeoylglucarate + L-quinate => chlorogenate + D-glucarate"}
{"X":26025,"RHEA_ID":43761,"DIRECTION":"LR","MASTER_ID":43760,"ecocyc":"RXN0-5231","compounds":"acetyl-CoA + N-terminal L-seryl-[ribosomal protein bL12] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[ribosomal protein bL12]"}
{"X":26026,"RHEA_ID":23208,"DIRECTION":"UN","MASTER_ID":23208,"ec":"2.8.3.12","compounds":"acetyl-CoA + trans-glutaconate = (2E)-glutaconyl-CoA + acetate"}
{"X":26027,"RHEA_ID":23209,"compounds":"acetyl-CoA + trans-glutaconate => (2E)-glutaconyl-CoA + acetate"}
{"X":26028,"RHEA_ID":23210,"compounds":"(2E)-glutaconyl-CoA + acetate => acetyl-CoA + trans-glutaconate"}
{"X":26029,"RHEA_ID":43765,"compounds":"ATP + chenodeoxycholate + CoA => AMP + chenodeoxycholoyl-CoA + diphosphate"}
{"X":26030,"RHEA_ID":23212,"DIRECTION":"UN","MASTER_ID":23212,"ec":"3.5.1.21","compounds":"H2O + N-acetyl-beta-alanine = acetate + beta-alanine"}
{"X":26031,"RHEA_ID":23213,"DIRECTION":"LR","MASTER_ID":23212,"metacyc":"N-ACETYL-BETA-ALANINE-DEACETYLASE-RXN","compounds":"H2O + N-acetyl-beta-alanine => acetate + beta-alanine"}
{"X":26032,"RHEA_ID":23214,"compounds":"acetate + beta-alanine => H2O + N-acetyl-beta-alanine"}
{"X":26033,"RHEA_ID":33846,"compounds":"H2O + N-tetracosanoylsphinganine <=> sphinganine + tetracosanoate"}
{"X":26034,"RHEA_ID":23216,"DIRECTION":"UN","MASTER_ID":23216,"ec":"1.14.13.58","compounds":"benzoyl-CoA + H(+) + NADPH + O2 = 3-hydroxybenzoyl-CoA + H2O + NADP(+)"}
{"X":26035,"RHEA_ID":23217,"DIRECTION":"LR","MASTER_ID":23216,"metacyc":"1.14.13.58-RXN","compounds":"benzoyl-CoA + H(+) + NADPH + O2 => 3-hydroxybenzoyl-CoA + H2O + NADP(+)"}
{"X":26036,"RHEA_ID":23218,"compounds":"3-hydroxybenzoyl-CoA + H2O + NADP(+) => benzoyl-CoA + H(+) + NADPH + O2"}
{"X":26037,"RHEA_ID":43773,"DIRECTION":"LR","MASTER_ID":43772,"ecocyc":"RXN0-6950","metacyc":"RXN0-6950","compounds":"guanosine(2069) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(2069) in 23S rRNA + S-adenosyl-L-homocysteine"}
{"X":26038,"RHEA_ID":23220,"DIRECTION":"UN","MASTER_ID":23220,"ec":"6.2.1.33","compounds":"4-chlorobenzoate + ATP + CoA = 4-chlorobenzoyl-CoA + AMP + diphosphate"}
{"X":26039,"RHEA_ID":23221,"DIRECTION":"LR","MASTER_ID":23220,"metacyc":"6.2.1.33-RXN","compounds":"4-chlorobenzoate + ATP + CoA => 4-chlorobenzoyl-CoA + AMP + diphosphate"}
{"X":26040,"RHEA_ID":23222,"compounds":"4-chlorobenzoyl-CoA + AMP + diphosphate => 4-chlorobenzoate + ATP + CoA"}
{"X":26041,"RHEA_ID":43777,"compounds":"an N-(acyl)-sphingosylphosphocholine(in) => an N-(acyl)-sphingosylphosphocholine(out)"}
{"X":26042,"RHEA_ID":23224,"DIRECTION":"UN","MASTER_ID":23224,"ec":"2.4.1.203","compounds":"trans-zeatin + UDP-alpha-D-glucose = H(+) + O-beta-D-glucosyl-trans-zeatin + UDP"}
{"X":26043,"RHEA_ID":23225,"DIRECTION":"LR","MASTER_ID":23224,"metacyc":"RXN-4723","compounds":"trans-zeatin + UDP-alpha-D-glucose => H(+) + O-beta-D-glucosyl-trans-zeatin + UDP"}
{"X":26044,"RHEA_ID":23226,"compounds":"H(+) + O-beta-D-glucosyl-trans-zeatin + UDP => trans-zeatin + UDP-alpha-D-glucose"}
{"X":26045,"RHEA_ID":43781,"compounds":"2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-2-methylbutenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":26046,"RHEA_ID":23228,"DIRECTION":"UN","MASTER_ID":23228,"ec":"1.14.13.59","compounds":"L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+)"}
{"X":26047,"RHEA_ID":23229,"DIRECTION":"LR","MASTER_ID":23228,"metacyc":"1.14.13.59-RXN","compounds":"L-lysine + NADPH + O2 => H2O + N(6)-hydroxy-L-lysine + NADP(+)"}
{"X":26048,"RHEA_ID":23230,"compounds":"H2O + N(6)-hydroxy-L-lysine + NADP(+) => L-lysine + NADPH + O2"}
{"X":26049,"RHEA_ID":53776,"compounds":"3-mercaptopropanoate + O2 = 3-sulfinopropanoate + H(+)"}
{"X":26050,"RHEA_ID":23232,"DIRECTION":"UN","MASTER_ID":23232,"ec":"1.7.2.8","compounds":"4 [Fe(III)cytochrome c] + hydrazine = 4 [Fe(II)cytochrome c] + 4 H(+) + N2"}
{"X":26051,"RHEA_ID":23233,"DIRECTION":"LR","MASTER_ID":23232,"metacyc":"1.7.99.8-RXN","compounds":"4 [Fe(III)cytochrome c] + hydrazine => 4 [Fe(II)cytochrome c] + 4 H(+) + N2"}
{"X":26052,"RHEA_ID":23234,"compounds":"4 [Fe(II)cytochrome c] + 4 H(+) + N2 => 4 [Fe(III)cytochrome c] + hydrazine"}
{"X":26053,"RHEA_ID":33866,"compounds":"menaquinone-7 + succinate <=> fumarate + menaquinol-7"}
{"X":26054,"RHEA_ID":23236,"DIRECTION":"UN","MASTER_ID":23236,"ec":"3.1.1.61","compounds":"[protein]-L-glutamate 5-O-methyl ester + H2O = H(+) + L-glutamyl-[protein] + methanol"}
{"X":26055,"RHEA_ID":23237,"DIRECTION":"LR","MASTER_ID":23236,"ecocyc":"MCPMETEST-RXN","metacyc":"MCPMETEST-RXN","compounds":"[protein]-L-glutamate 5-O-methyl ester + H2O => H(+) + L-glutamyl-[protein] + methanol"}
{"X":26056,"RHEA_ID":23238,"compounds":"H(+) + L-glutamyl-[protein] + methanol => [protein]-L-glutamate 5-O-methyl ester + H2O"}
{"X":26057,"RHEA_ID":43793,"DIRECTION":"LR","MASTER_ID":43792,"metacyc":"RXN-14550","compounds":"adenosine(645) in 25S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyladenosine(645) in 25S rRNA + S-adenosyl-L-homocysteine"}
{"X":26058,"RHEA_ID":23240,"DIRECTION":"UN","MASTER_ID":23240,"ec":"2.1.2.5","compounds":"5-formyltetrahydrofolate + L-glutamate = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-glutamate"}
{"X":26059,"RHEA_ID":23241,"compounds":"5-formyltetrahydrofolate + L-glutamate => (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-glutamate"}
{"X":26060,"RHEA_ID":23242,"compounds":"(6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-glutamate => 5-formyltetrahydrofolate + L-glutamate"}
{"X":26061,"RHEA_ID":33874,"compounds":"(S)-2-ureidoglycine + H2O <=> glyoxylate + NH4(+) + urea"}
{"X":26062,"RHEA_ID":23244,"DIRECTION":"UN","MASTER_ID":23244,"ec":"2.5.1.23","compounds":"propane-1,3-diamine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + norspermidine + S-methyl-5'-thioadenosine"}
{"X":26063,"RHEA_ID":23245,"compounds":"propane-1,3-diamine + S-adenosyl 3-(methylsulfanyl)propylamine => H(+) + norspermidine + S-methyl-5'-thioadenosine"}
{"X":26064,"RHEA_ID":23246,"compounds":"H(+) + norspermidine + S-methyl-5'-thioadenosine => propane-1,3-diamine + S-adenosyl 3-(methylsulfanyl)propylamine"}
{"X":26065,"RHEA_ID":43801,"compounds":"1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":26066,"RHEA_ID":23248,"DIRECTION":"UN","MASTER_ID":23248,"ec":"2.1.1.129","compounds":"myo-inositol + S-adenosyl-L-methionine = 1D-4-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine"}
{"X":26067,"RHEA_ID":23249,"DIRECTION":"LR","MASTER_ID":23248,"metacyc":"2.1.1.129-RXN","compounds":"myo-inositol + S-adenosyl-L-methionine => 1D-4-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine"}
{"X":26068,"RHEA_ID":23250,"compounds":"1D-4-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine => myo-inositol + S-adenosyl-L-methionine"}
{"X":26069,"RHEA_ID":53796,"compounds":"deoxycholoyl-CoA + ursodeoxycholate = deoxycholate + ursodeoxycholoyl-CoA"}
{"X":26070,"RHEA_ID":23252,"DIRECTION":"UN","MASTER_ID":23252,"ec":"1.17.4.1","compounds":"[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate"}
{"X":26071,"RHEA_ID":23253,"compounds":"[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O => [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate"}
{"X":26072,"RHEA_ID":23254,"DIRECTION":"RL","MASTER_ID":23252,"ecocyc":"RIBONUCLEOSIDE-DIP-REDUCTI-RXN","metacyc":"RIBONUCLEOSIDE-DIP-REDUCTI-RXN","compounds":"[thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate => [thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O"}
{"X":26073,"RHEA_ID":43813,"compounds":"1,2-dioctadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine"}
{"X":26074,"RHEA_ID":23256,"DIRECTION":"UN","MASTER_ID":23256,"ec":"6.3.5.10","compounds":"adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H2O + 4 L-glutamine = adenosylcob(III)yrate + 4 ADP + 4 H(+) + 4 L-glutamate + 4 phosphate"}
{"X":26075,"RHEA_ID":23257,"DIRECTION":"LR","MASTER_ID":23256,"metacyc":"R345-RXN","compounds":"adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H2O + 4 L-glutamine => adenosylcob(III)yrate + 4 ADP + 4 H(+) + 4 L-glutamate + 4 phosphate"}
{"X":26076,"RHEA_ID":23258,"compounds":"adenosylcob(III)yrate + 4 ADP + 4 H(+) + 4 L-glutamate + 4 phosphate => adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H2O + 4 L-glutamine"}
{"X":26077,"RHEA_ID":53804,"compounds":"allodeoxycholoyl-CoA + ursodeoxycholate = allodeoxycholate + ursodeoxycholoyl-CoA"}
{"X":26078,"RHEA_ID":23260,"DIRECTION":"UN","MASTER_ID":23260,"ec":"1.1.1.232","compounds":"(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NAD(+) = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADH"}
{"X":26079,"RHEA_ID":23261,"DIRECTION":"LR","MASTER_ID":23260,"reactome":"R-HSA-2161789.2","compounds":"(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NAD(+) => 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADH"}
{"X":26080,"RHEA_ID":23262,"compounds":"15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADH => (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NAD(+)"}
{"X":26081,"RHEA_ID":43821,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":26082,"RHEA_ID":23264,"DIRECTION":"UN","MASTER_ID":23264,"ec":"1.1.1.232","compounds":"(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NADP(+) = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADPH"}
{"X":26083,"RHEA_ID":23265,"DIRECTION":"LR","MASTER_ID":23264,"reactome":"R-HSA-2161789.2","compounds":"(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NADP(+) => 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADPH"}
{"X":26084,"RHEA_ID":23266,"compounds":"15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADPH => (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NADP(+)"}
{"X":26085,"RHEA_ID":53812,"compounds":"cholestanol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-26-hydroxycholestanol + H2O + 2 oxidized [adrenodoxin]"}
{"X":26086,"RHEA_ID":23268,"DIRECTION":"UN","MASTER_ID":23268,"ec":"3.5.3.2","metacyc":"GUANIDINOACETASE-RXN","compounds":"guanidinoacetate + H2O = glycine + urea"}
{"X":26087,"RHEA_ID":23269,"compounds":"guanidinoacetate + H2O => glycine + urea"}
{"X":26088,"RHEA_ID":23270,"compounds":"glycine + urea => guanidinoacetate + H2O"}
{"X":26089,"RHEA_ID":43829,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)"}
{"X":26090,"RHEA_ID":23272,"DIRECTION":"UN","MASTER_ID":23272,"ec":"2.4.1.118","compounds":"an N(6)-alkylaminopurine + UDP-alpha-D-glucose = an N(6)-alkylamino-7-beta-D-glucosylpurine + H(+) + UDP"}
{"X":26091,"RHEA_ID":23273,"DIRECTION":"LR","MASTER_ID":23272,"metacyc":"CYTOKININ-7-BETA-GLUCOSYLTRANSFERASE-RXN","compounds":"an N(6)-alkylaminopurine + UDP-alpha-D-glucose => an N(6)-alkylamino-7-beta-D-glucosylpurine + H(+) + UDP"}
{"X":26092,"RHEA_ID":23274,"compounds":"an N(6)-alkylamino-7-beta-D-glucosylpurine + H(+) + UDP => an N(6)-alkylaminopurine + UDP-alpha-D-glucose"}
{"X":26093,"RHEA_ID":53820,"compounds":"chenodeoxycholate + NADP(+) = 7-oxolithocholate + H(+) + NADPH"}
{"X":26094,"RHEA_ID":23276,"DIRECTION":"UN","MASTER_ID":23276,"ec":"4.1.2.12","metacyc":"KETOPANTOALDOLASE-RXN","compounds":"2-dehydropantoate = 3-methyl-2-oxobutanoate + formaldehyde"}
{"X":26095,"RHEA_ID":23277,"compounds":"2-dehydropantoate => 3-methyl-2-oxobutanoate + formaldehyde"}
{"X":26096,"RHEA_ID":23278,"compounds":"3-methyl-2-oxobutanoate + formaldehyde => 2-dehydropantoate"}
{"X":26097,"RHEA_ID":43837,"DIRECTION":"LR","MASTER_ID":43836,"reactome":"R-HSA-192123.1","compounds":"cholesterol + H(+) + NADPH + O2 => 26-hydroxycholesterol + H2O + NADP(+)"}
{"X":26098,"RHEA_ID":23280,"DIRECTION":"UN","MASTER_ID":23280,"ec":"2.3.1.11","metacyc":"THIOETHANOLAMINE-S-ACETYLTRANSFERASE-RXN","compounds":"acetyl-CoA + cysteamine = CoA + S-acetylcysteamine"}
{"X":26099,"RHEA_ID":23281,"compounds":"acetyl-CoA + cysteamine => CoA + S-acetylcysteamine"}
{"X":26100,"RHEA_ID":23282,"compounds":"CoA + S-acetylcysteamine => acetyl-CoA + cysteamine"}
{"X":26101,"RHEA_ID":43841,"compounds":"26-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (3beta)-hydroxy-cholest-5-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":26102,"RHEA_ID":23284,"DIRECTION":"UN","MASTER_ID":23284,"ec":"5.3.3.2","compounds":"isopentenyl diphosphate = dimethylallyl diphosphate"}
{"X":26103,"RHEA_ID":23285,"DIRECTION":"LR","MASTER_ID":23284,"macie":"M0190","reactome":"R-HSA-191382.1","compounds":"isopentenyl diphosphate => dimethylallyl diphosphate"}
{"X":26104,"RHEA_ID":23286,"compounds":"dimethylallyl diphosphate => isopentenyl diphosphate"}
{"X":26105,"RHEA_ID":53832,"compounds":"2-oxoglutarate + a 5-formyl-2'-deoxycytidine in DNA + O2 = a 5-carboxyl-2'-deoxycytidine in DNA + CO2 + H(+) + succinate"}
{"X":26106,"RHEA_ID":23288,"DIRECTION":"UN","MASTER_ID":23288,"ec":"1.2.1.10","compounds":"acetaldehyde + CoA + NAD(+) = acetyl-CoA + H(+) + NADH"}
{"X":26107,"RHEA_ID":23289,"compounds":"acetaldehyde + CoA + NAD(+) => acetyl-CoA + H(+) + NADH"}
{"X":26108,"RHEA_ID":23290,"compounds":"acetyl-CoA + H(+) + NADH => acetaldehyde + CoA + NAD(+)"}
{"X":26109,"RHEA_ID":53836,"compounds":"a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-acyl-alpha-D-glucosamine = a UDP-2-N,3-O-bis((3R)-3-hydroxyacyl)-alpha-D-glucosamine + H(+) + holo-[ACP]"}
{"X":26110,"RHEA_ID":23292,"DIRECTION":"UN","MASTER_ID":23292,"ec":"2.7.3.5","compounds":"ATP + L-lombricine = ADP + H(+) + N-phospho-L-lombricine"}
{"X":26111,"RHEA_ID":23293,"compounds":"ATP + L-lombricine => ADP + H(+) + N-phospho-L-lombricine"}
{"X":26112,"RHEA_ID":23294,"compounds":"ADP + H(+) + N-phospho-L-lombricine => ATP + L-lombricine"}
{"X":26113,"RHEA_ID":53844,"compounds":"glycochenodeoxycholate + NAD(+) = 7-oxo-glycolithocholate + H(+) + NADH"}
{"X":26114,"RHEA_ID":23296,"DIRECTION":"UN","MASTER_ID":23296,"ec":"4.1.3.3","compounds":"N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate"}
{"X":26115,"RHEA_ID":23297,"DIRECTION":"LR","MASTER_ID":23296,"reactome":"R-HSA-4085217.1","compounds":"N-acetylneuraminate => N-acetyl-D-mannosamine + pyruvate"}
{"X":26116,"RHEA_ID":23298,"compounds":"N-acetyl-D-mannosamine + pyruvate => N-acetylneuraminate"}
{"X":26117,"RHEA_ID":53848,"compounds":"NAD(+) + taurocholate = 7-oxo-taurodeoxycholate + H(+) + NADH"}
{"X":26118,"RHEA_ID":23300,"DIRECTION":"UN","MASTER_ID":23300,"ec":"2.5.1.68","compounds":"(2E)-geranyl diphosphate + isopentenyl diphosphate = (2Z,6E)-farnesyl diphosphate + diphosphate"}
{"X":26119,"RHEA_ID":23301,"DIRECTION":"LR","MASTER_ID":23300,"metacyc":"2.5.1.68-RXN","compounds":"(2E)-geranyl diphosphate + isopentenyl diphosphate => (2Z,6E)-farnesyl diphosphate + diphosphate"}
{"X":26120,"RHEA_ID":23302,"compounds":"(2Z,6E)-farnesyl diphosphate + diphosphate => (2E)-geranyl diphosphate + isopentenyl diphosphate"}
{"X":26121,"RHEA_ID":53852,"compounds":"glycocholate + NAD(+) = 7-oxo-glycodeoxycholate + H(+) + NADH"}
{"X":26122,"RHEA_ID":23304,"DIRECTION":"UN","MASTER_ID":23304,"ec":"3.1.1.10","compounds":"atropine + H2O = H(+) + tropate + tropine"}
{"X":26123,"RHEA_ID":23305,"DIRECTION":"LR","MASTER_ID":23304,"metacyc":"TROPINESTERASE-RXN","compounds":"atropine + H2O => H(+) + tropate + tropine"}
{"X":26124,"RHEA_ID":23306,"compounds":"H(+) + tropate + tropine => atropine + H2O"}
{"X":26125,"RHEA_ID":43865,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine(in) => 1-hexadecanoyl-sn-glycero-3-phosphocholine(out)"}
{"X":26126,"RHEA_ID":23308,"DIRECTION":"UN","MASTER_ID":23308,"ec":"2.3.1.131","compounds":"D-glucarate + sinapoyl-CoA = 2-O-sinapoyl-D-glucarate + CoA"}
{"X":26127,"RHEA_ID":23309,"DIRECTION":"LR","MASTER_ID":23308,"metacyc":"2.3.1.131-RXN","compounds":"D-glucarate + sinapoyl-CoA => 2-O-sinapoyl-D-glucarate + CoA"}
{"X":26128,"RHEA_ID":23310,"compounds":"2-O-sinapoyl-D-glucarate + CoA => D-glucarate + sinapoyl-CoA"}
{"X":26129,"RHEA_ID":33942,"compounds":"H(+) + L-arginine + NADH + O2 <=> H2O + N(omega)-hydroxy-L-arginine + NAD(+)"}
{"X":26130,"RHEA_ID":23312,"DIRECTION":"UN","MASTER_ID":23312,"ec":"2.4.1.99","compounds":"2 sucrose = 1(F)-beta-D-fructosylsucrose + D-glucose"}
{"X":26131,"RHEA_ID":23313,"DIRECTION":"LR","MASTER_ID":23312,"metacyc":"RXN-1781","compounds":"2 sucrose => 1(F)-beta-D-fructosylsucrose + D-glucose"}
{"X":26132,"RHEA_ID":23314,"compounds":"1(F)-beta-D-fructosylsucrose + D-glucose => 2 sucrose"}
{"X":26133,"RHEA_ID":53864,"compounds":"3alpha,7beta-dihydroxy-12-oxo-5beta-cholan-24-oate + NADP(+) = 7,12-dioxo-lithocholate + H(+) + NADPH"}
{"X":26134,"RHEA_ID":23316,"DIRECTION":"UN","MASTER_ID":23316,"ec":"1.14.11.10","compounds":"2'-deoxyuridine + 2-oxoglutarate + O2 = 2-deoxy-D-ribono-1,4-lactone + CO2 + succinate + uracil"}
{"X":26135,"RHEA_ID":23317,"DIRECTION":"LR","MASTER_ID":23316,"metacyc":"1.14.11.10-RXN","compounds":"2'-deoxyuridine + 2-oxoglutarate + O2 => 2-deoxy-D-ribono-1,4-lactone + CO2 + succinate + uracil"}
{"X":26136,"RHEA_ID":23318,"compounds":"2-deoxy-D-ribono-1,4-lactone + CO2 + succinate + uracil => 2'-deoxyuridine + 2-oxoglutarate + O2"}
{"X":26137,"RHEA_ID":53868,"DIRECTION":"UN","MASTER_ID":53868,"ec":"1.14.13.218","compounds":"2 H(+) + NADH + O2 + phenazine-1-carboxylate = 1-hydroxyphenazine + CO2 + H2O + NAD(+)"}
{"X":26138,"RHEA_ID":23320,"DIRECTION":"UN","MASTER_ID":23320,"ec":"2.3.1.112","metacyc":"D-TRYPTOPHAN-N-MALONYLTRANSFERASE-RXN","compounds":"D-tryptophan + malonyl-CoA = CoA + H(+) + N(2)-malonyl-D-tryptophan"}
{"X":26139,"RHEA_ID":23321,"compounds":"D-tryptophan + malonyl-CoA => CoA + H(+) + N(2)-malonyl-D-tryptophan"}
{"X":26140,"RHEA_ID":23322,"compounds":"CoA + H(+) + N(2)-malonyl-D-tryptophan => D-tryptophan + malonyl-CoA"}
{"X":26141,"RHEA_ID":53872,"compounds":"CTP + D-ribose 5-phosphate + H(+) = CDP-D-ribose + diphosphate"}
{"X":26142,"RHEA_ID":23324,"DIRECTION":"UN","MASTER_ID":23324,"ec":"2.7.1.160","compounds":"2'-phospho-[ligated tRNA] + NAD(+) = ADP-D-ribose 1'',2''-cyclic phosphate + mature tRNA + nicotinamide"}
{"X":26143,"RHEA_ID":23325,"DIRECTION":"LR","MASTER_ID":23324,"metacyc":"2.7.1.160-RXN","compounds":"2'-phospho-[ligated tRNA] + NAD(+) => ADP-D-ribose 1'',2''-cyclic phosphate + mature tRNA + nicotinamide"}
{"X":26144,"RHEA_ID":23326,"compounds":"ADP-D-ribose 1'',2''-cyclic phosphate + mature tRNA + nicotinamide => 2'-phospho-[ligated tRNA] + NAD(+)"}
{"X":26145,"RHEA_ID":43885,"compounds":"3-oxochol-4-en-22-oyl-CoA + NAD(+) => 3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH"}
{"X":26146,"RHEA_ID":23328,"DIRECTION":"UN","MASTER_ID":23328,"ec":"1.13.11.51","compounds":"a 9-cis-epoxycarotenoid + O2 = 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal"}
{"X":26147,"RHEA_ID":23329,"DIRECTION":"LR","MASTER_ID":23328,"metacyc":"RXN-7973","compounds":"a 9-cis-epoxycarotenoid + O2 => 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal"}
{"X":26148,"RHEA_ID":23330,"compounds":"2-cis,4-trans-xanthoxin + a 12'-apo-carotenal => a 9-cis-epoxycarotenoid + O2"}
{"X":26149,"RHEA_ID":43889,"compounds":"[sulfur carrier]-H + [sulfur-carrier protein]-S-sulfanyl-L-cysteine => [sulfur carrier]-SH + [sulfur-carrier protein]-L-cysteine"}
{"X":26150,"RHEA_ID":23332,"DIRECTION":"UN","MASTER_ID":23332,"ec":"2.7.2.10","metacyc":"PHOSPHOGLYCERATE-KINASE-GTP-RXN","compounds":"(2R)-3-phosphoglycerate + GTP = (2R)-3-phospho-glyceroyl phosphate + GDP"}
{"X":26151,"RHEA_ID":23333,"compounds":"(2R)-3-phosphoglycerate + GTP => (2R)-3-phospho-glyceroyl phosphate + GDP"}
{"X":26152,"RHEA_ID":23334,"compounds":"(2R)-3-phospho-glyceroyl phosphate + GDP => (2R)-3-phosphoglycerate + GTP"}
{"X":26153,"RHEA_ID":43893,"DIRECTION":"LR","MASTER_ID":43892,"ecocyc":"RXN-12588","metacyc":"RXN-12588","compounds":"[sulfur carrier]-H + L-cysteine => [sulfur carrier]-SH + L-alanine"}
{"X":26154,"RHEA_ID":33967,"DIRECTION":"UN","MASTER_ID":33967,"ec":"3.1.1.91","compounds":"2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H2O = 3-maleylpyruvate + H(+)"}
{"X":26155,"RHEA_ID":23337,"DIRECTION":"LR","MASTER_ID":23336,"metacyc":"IODIDE-PEROXIDASE-RXN","compounds":"2 H(+) + H2O2 + 2 iodide => diiodine + 2 H2O"}
{"X":26156,"RHEA_ID":23338,"compounds":"diiodine + 2 H2O => 2 H(+) + H2O2 + 2 iodide"}
{"X":26157,"RHEA_ID":23340,"DIRECTION":"UN","MASTER_ID":23340,"ec":"4.1.2.23","metacyc":"4.1.2.23-RXN","compounds":"3-deoxy-alpha-D-manno-oct-2-ulosonate = D-arabinose + pyruvate"}
{"X":26158,"RHEA_ID":23341,"compounds":"3-deoxy-alpha-D-manno-oct-2-ulosonate => D-arabinose + pyruvate"}
{"X":26159,"RHEA_ID":23342,"compounds":"D-arabinose + pyruvate => 3-deoxy-alpha-D-manno-oct-2-ulosonate"}
{"X":26160,"RHEA_ID":43901,"DIRECTION":"LR","MASTER_ID":43900,"metacyc":"RXN-9163","compounds":"dalpatein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O => beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalpatein + H(+)"}
{"X":26161,"RHEA_ID":33975,"DIRECTION":"UN","MASTER_ID":33975,"ec":"3.2.1.182","compounds":"DIMBOA beta-D-glucoside + H2O = D-glucose + DIMBOA"}
{"X":26162,"RHEA_ID":23345,"DIRECTION":"LR","MASTER_ID":23344,"metacyc":"PURINE-NUCLEOSIDASE-RXN","compounds":"a purine D-ribonucleoside + H2O => a purine nucleobase + D-ribose"}
{"X":26163,"RHEA_ID":23346,"compounds":"a purine nucleobase + D-ribose => a purine D-ribonucleoside + H2O"}
{"X":26164,"RHEA_ID":33978,"compounds":"DIMBOA beta-D-glucoside + H2O <=> D-glucose + DIMBOA"}
{"X":26165,"RHEA_ID":33979,"DIRECTION":"UN","MASTER_ID":33979,"ec":"3.2.1.182","compounds":"DIBOA beta-D-glucoside + H2O = D-glucose + DIBOA"}
{"X":26166,"RHEA_ID":23349,"DIRECTION":"LR","MASTER_ID":23348,"metacyc":"4-CARBOXYMUCONOLACTONE-DECARBOXYLASE-RXN","compounds":"(R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H(+) => (4,5-dihydro-5-oxofuran-2-yl)-acetate + CO2"}
{"X":26167,"RHEA_ID":23350,"compounds":"(4,5-dihydro-5-oxofuran-2-yl)-acetate + CO2 => (R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H(+)"}
{"X":26168,"RHEA_ID":33982,"compounds":"DIBOA beta-D-glucoside + H2O <=> D-glucose + DIBOA"}
{"X":26169,"RHEA_ID":33983,"DIRECTION":"UN","MASTER_ID":33983,"ec":"4.2.3.131","compounds":"(+)-copalyl diphosphate = diphosphate + miltiradiene"}
{"X":26170,"RHEA_ID":23353,"DIRECTION":"LR","MASTER_ID":23352,"reactome":"R-HSA-916855.3","compounds":"2-oxoglutarate + 4-aminobutanoate => L-glutamate + succinate semialdehyde"}
{"X":26171,"RHEA_ID":23354,"compounds":"L-glutamate + succinate semialdehyde => 2-oxoglutarate + 4-aminobutanoate"}
{"X":26172,"RHEA_ID":43913,"DIRECTION":"LR","MASTER_ID":43912,"metacyc":"RXN-17646","compounds":"cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (25R)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":26173,"RHEA_ID":33987,"DIRECTION":"UN","MASTER_ID":33987,"ec":"4.2.3.132","compounds":"(+)-copalyl diphosphate = diphosphate + neoabietadiene"}
{"X":26174,"RHEA_ID":23357,"compounds":"[rhodopsin]-L-serine + ATP => [rhodopsin]-O-phospho-L-serine + ADP + H(+)"}
{"X":26175,"RHEA_ID":23358,"compounds":"[rhodopsin]-O-phospho-L-serine + ADP + H(+) => [rhodopsin]-L-serine + ATP"}
{"X":26176,"RHEA_ID":43917,"DIRECTION":"LR","MASTER_ID":43916,"metacyc":"RXN-17647","compounds":"(25R)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (25R)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":26177,"RHEA_ID":23360,"DIRECTION":"UN","MASTER_ID":23360,"ec":"2.4.1.186","compounds":"L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-glucosyl-L-tyrosyl-[glycogenin] + H(+) + UDP"}
{"X":26178,"RHEA_ID":23361,"DIRECTION":"LR","MASTER_ID":23360,"metacyc":"GLYCOGENIN-GLUCOSYLTRANSFERASE-RXN","compounds":"L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose => alpha-D-glucosyl-L-tyrosyl-[glycogenin] + H(+) + UDP"}
{"X":26179,"RHEA_ID":23362,"compounds":"alpha-D-glucosyl-L-tyrosyl-[glycogenin] + H(+) + UDP => L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose"}
{"X":26180,"RHEA_ID":43921,"DIRECTION":"LR","MASTER_ID":43920,"metacyc":"RXN-17648","compounds":"(25R)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (25R)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":26181,"RHEA_ID":33995,"DIRECTION":"UN","MASTER_ID":33995,"ec":"4.3.2.6","compounds":"gamma-L-glutamyl-butirosin B = 5-oxo-L-proline + butirosin B"}
{"X":26182,"RHEA_ID":23369,"DIRECTION":"LR","MASTER_ID":23368,"macie":"M0220","metacyc":"BENZOYLFORMATE-DECARBOXYLASE-RXN","compounds":"H(+) + phenylglyoxylate => benzaldehyde + CO2"}
{"X":26183,"RHEA_ID":23370,"compounds":"benzaldehyde + CO2 => H(+) + phenylglyoxylate"}
{"X":26184,"RHEA_ID":43925,"DIRECTION":"LR","MASTER_ID":43924,"reactome":"R-HSA-196350.1","compounds":"NAD(+) + pregnenolone => H(+) + NADH + pregn-5-ene-3,20-dione"}
{"X":26185,"RHEA_ID":33999,"compounds":"5alpha-cholesta-8,24-dien-3beta-ol = 5alpha-cholesta-7,24-dien-3beta-ol"}
{"X":26186,"RHEA_ID":23373,"DIRECTION":"LR","MASTER_ID":23372,"ecocyc":"UDP-NACMUR-ALA-LIG-RXN","metacyc":"UDP-NACMUR-ALA-LIG-RXN","compounds":"ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine"}
{"X":26187,"RHEA_ID":23374,"compounds":"ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine => ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate"}
{"X":26188,"RHEA_ID":34002,"compounds":"5alpha-cholesta-8,24-dien-3beta-ol <=> 5alpha-cholesta-7,24-dien-3beta-ol"}
{"X":26189,"RHEA_ID":34003,"compounds":"5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH + O2 = cholesta-5,7,24-trien-3beta-ol + 2 H2O + NADP(+)"}
{"X":26190,"RHEA_ID":23377,"compounds":"L-threonate + NAD(+) => 3-dehydro-D-erythronate + H(+) + NADH"}
{"X":26191,"RHEA_ID":23378,"compounds":"3-dehydro-D-erythronate + H(+) + NADH => L-threonate + NAD(+)"}
{"X":26192,"RHEA_ID":34006,"compounds":"5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH + O2 <=> cholesta-5,7,24-trien-3beta-ol + 2 H2O + NADP(+)"}
{"X":26193,"RHEA_ID":34007,"compounds":"cholesta-5,7,24-trien-3beta-ol + S-adenosyl-L-methionine = ergosta-5,7,24(28)-trien-3beta-ol + H(+) + S-adenosyl-L-homocysteine"}
{"X":26194,"RHEA_ID":23381,"DIRECTION":"LR","MASTER_ID":23380,"metacyc":"2.4.1.141-RXN","compounds":"N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N,N'-diacetylchitobiosyl diphosphodolichol + UDP"}
{"X":26195,"RHEA_ID":23382,"compounds":"H(+) + N,N'-diacetylchitobiosyl diphosphodolichol + UDP => N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":26196,"RHEA_ID":34010,"compounds":"cholesta-5,7,24-trien-3beta-ol + S-adenosyl-L-methionine <=> ergosta-5,7,24(28)-trien-3beta-ol + H(+) + S-adenosyl-L-homocysteine"}
{"X":26197,"RHEA_ID":34011,"compounds":"ergosta-5,7,24(28)-trien-3beta-ol + 2 H2O + NADP(+) = ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2"}
{"X":26198,"RHEA_ID":23385,"compounds":"D-cellobiose => beta-D-glucosyl-(1->4)-D-mannopyranose"}
{"X":26199,"RHEA_ID":23386,"compounds":"beta-D-glucosyl-(1->4)-D-mannopyranose => D-cellobiose"}
{"X":26200,"RHEA_ID":34014,"compounds":"ergosta-5,7,24(28)-trien-3beta-ol + 2 H2O + NADP(+) <=> ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2"}
{"X":26201,"RHEA_ID":34015,"compounds":"ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2 = ergosterol + 2 H2O + NADP(+)"}
{"X":26202,"RHEA_ID":23389,"compounds":"ATP + hygromycin B => 7''-O-phosphohygromycin B + ADP + H(+)"}
{"X":26203,"RHEA_ID":23390,"compounds":"7''-O-phosphohygromycin B + ADP + H(+) => ATP + hygromycin B"}
{"X":26204,"RHEA_ID":34018,"compounds":"ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2 <=> ergosterol + 2 H2O + NADP(+)"}
{"X":26205,"RHEA_ID":34019,"compounds":"a 1-acylglycerol + H2O = a fatty acid + glycerol + H(+)"}
{"X":26206,"RHEA_ID":23393,"DIRECTION":"LR","MASTER_ID":23392,"macie":"M0178","compounds":"(nucleoside 5'-monophosphate)n + (n-1) H2O => n a ribonucleoside 5'-phosphate + n H(+)"}
{"X":26207,"RHEA_ID":23393,"DIRECTION":"LR","MASTER_ID":23392,"macie":"M0179","compounds":"(nucleoside 5'-monophosphate)n + (n-1) H2O => n a ribonucleoside 5'-phosphate + n H(+)"}
{"X":26208,"RHEA_ID":23394,"compounds":"n a ribonucleoside 5'-phosphate + n H(+) => (nucleoside 5'-monophosphate)n + (n-1) H2O"}
{"X":26209,"RHEA_ID":34023,"DIRECTION":"UN","MASTER_ID":34023,"ec":"1.1.1.328","compounds":"3,3'-bipyridine-2,2',5,5',6,6'-hexol + NAD(+) = (E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADH"}
{"X":26210,"RHEA_ID":23396,"DIRECTION":"UN","MASTER_ID":23396,"ec":"3.7.1.4","compounds":"H2O + phloretin = 1,3,5-trihydroxybenzene + H(+) + phloretate"}
{"X":26211,"RHEA_ID":23397,"compounds":"H2O + phloretin => 1,3,5-trihydroxybenzene + H(+) + phloretate"}
{"X":26212,"RHEA_ID":23398,"compounds":"1,3,5-trihydroxybenzene + H(+) + phloretate => H2O + phloretin"}
{"X":26213,"RHEA_ID":34027,"DIRECTION":"UN","MASTER_ID":34027,"ec":"1.1.1.328","compounds":"3,3'-bipyridine-2,2',5,5',6,6'-hexol + NADP(+) = (E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADPH"}
{"X":26214,"RHEA_ID":23400,"DIRECTION":"UN","MASTER_ID":23400,"ec":"1.13.11.10","compounds":"7,8-dihydroxykynurenate + O2 = 5-(3-carboxy-3-oxoprop-1-en-1-yl)-4,6-dihydroxypyridine-2-carboxylate + H(+)"}
{"X":26215,"RHEA_ID":23401,"DIRECTION":"LR","MASTER_ID":23400,"metacyc":"1.13.11.10-RXN","compounds":"7,8-dihydroxykynurenate + O2 => 5-(3-carboxy-3-oxoprop-1-en-1-yl)-4,6-dihydroxypyridine-2-carboxylate + H(+)"}
{"X":26216,"RHEA_ID":23402,"compounds":"5-(3-carboxy-3-oxoprop-1-en-1-yl)-4,6-dihydroxypyridine-2-carboxylate + H(+) => 7,8-dihydroxykynurenate + O2"}
{"X":26217,"RHEA_ID":43970,"compounds":"2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O"}
{"X":26218,"RHEA_ID":23404,"DIRECTION":"UN","MASTER_ID":23404,"ec":"2.5.1.41","compounds":"all-trans-geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate"}
{"X":26219,"RHEA_ID":23405,"DIRECTION":"LR","MASTER_ID":23404,"metacyc":"2.5.1.41-RXN","compounds":"all-trans-geranylgeranyl diphosphate + sn-glycerol 1-phosphate => diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate"}
{"X":26220,"RHEA_ID":23406,"compounds":"diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate => all-trans-geranylgeranyl diphosphate + sn-glycerol 1-phosphate"}
{"X":26221,"RHEA_ID":43974,"compounds":"H(+) + hexadecanoate + hexadecanoyl-glycero-3-phospho-(1D-myo-inositol) => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O"}
{"X":26222,"RHEA_ID":23408,"DIRECTION":"UN","MASTER_ID":23408,"ec":"1.3.1.54","compounds":"NADP(+) + precorrin-6B = 2 H(+) + NADPH + precorrin-6A"}
{"X":26223,"RHEA_ID":23409,"compounds":"NADP(+) + precorrin-6B => 2 H(+) + NADPH + precorrin-6A"}
{"X":26224,"RHEA_ID":23410,"compounds":"2 H(+) + NADPH + precorrin-6A => NADP(+) + precorrin-6B"}
{"X":26225,"RHEA_ID":43978,"compounds":"14-hydroxyhexadecanoate + H2O + NADP(+) => H(+) + hexadecanoate + NADPH + O2"}
{"X":26226,"RHEA_ID":23412,"DIRECTION":"UN","MASTER_ID":23412,"ec":"3.5.1.62","compounds":"H2O + N-acetylputrescine = acetate + putrescine"}
{"X":26227,"RHEA_ID":23413,"compounds":"H2O + N-acetylputrescine => acetate + putrescine"}
{"X":26228,"RHEA_ID":23414,"compounds":"acetate + putrescine => H2O + N-acetylputrescine"}
{"X":26229,"RHEA_ID":34043,"DIRECTION":"UN","MASTER_ID":34043,"ec":"2.4.2.49","compounds":"5-phospho-alpha-D-ribose 1-diphosphate + neamine = 5''-phosphoribostamycin + diphosphate"}
{"X":26230,"RHEA_ID":23416,"DIRECTION":"UN","MASTER_ID":23416,"ec":"3.1.3.71","compounds":"(2R)-O-phospho-3-sulfolactate + H2O = (R)-3-sulfolactate + phosphate"}
{"X":26231,"RHEA_ID":23417,"DIRECTION":"LR","MASTER_ID":23416,"metacyc":"R229-RXN","compounds":"(2R)-O-phospho-3-sulfolactate + H2O => (R)-3-sulfolactate + phosphate"}
{"X":26232,"RHEA_ID":23418,"compounds":"(R)-3-sulfolactate + phosphate => (2R)-O-phospho-3-sulfolactate + H2O"}
{"X":26233,"RHEA_ID":43986,"compounds":"(2E,6E)-omega-hydroxy-farnesol + H2O + NADP(+) => (2E,6E)-farnesol + H(+) + NADPH + O2"}
{"X":26234,"RHEA_ID":23420,"DIRECTION":"UN","MASTER_ID":23420,"ec":"3.1.3.12","compounds":"alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-trehalose + phosphate"}
{"X":26235,"RHEA_ID":23421,"DIRECTION":"LR","MASTER_ID":23420,"ecocyc":"TREHALOSEPHOSPHA-RXN","compounds":"alpha,alpha-trehalose 6-phosphate + H2O => alpha,alpha-trehalose + phosphate"}
{"X":26236,"RHEA_ID":23422,"compounds":"alpha,alpha-trehalose + phosphate => alpha,alpha-trehalose 6-phosphate + H2O"}
{"X":26237,"RHEA_ID":34051,"DIRECTION":"UN","MASTER_ID":34051,"ec":"3.5.1.113","compounds":"2'''-acetyl-6'''-hydroxyneomycin C + H2O = 6'''-deamino-6'''-hydroxyneomycin C + acetate"}
{"X":26238,"RHEA_ID":23424,"DIRECTION":"UN","MASTER_ID":23424,"ec":"5.4.2.10","compounds":"alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate"}
{"X":26239,"RHEA_ID":23425,"compounds":"alpha-D-glucosamine 1-phosphate => D-glucosamine 6-phosphate"}
{"X":26240,"RHEA_ID":23426,"compounds":"D-glucosamine 6-phosphate => alpha-D-glucosamine 1-phosphate"}
{"X":26241,"RHEA_ID":43994,"compounds":"16-hydroxy-(2E,6E,10E)-geranylgeraniol + H2O + NADP(+) => (2E,6E,10E)-geranylgeraniol + H(+) + NADPH + O2"}
{"X":26242,"RHEA_ID":23428,"DIRECTION":"UN","MASTER_ID":23428,"ec":"2.4.1.226","compounds":"3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP"}
{"X":26243,"RHEA_ID":23429,"DIRECTION":"LR","MASTER_ID":23428,"metacyc":"RXN-16324","compounds":"3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate => 3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP"}
{"X":26244,"RHEA_ID":23430,"compounds":"3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate"}
{"X":26245,"RHEA_ID":34059,"DIRECTION":"UN","MASTER_ID":34059,"ec":"1.5.1.46","compounds":"agroclavine + NADP(+) = didehydroagroclavine + H(+) + NADPH"}
{"X":26246,"RHEA_ID":23432,"DIRECTION":"UN","MASTER_ID":23432,"ec":"1.14.14.52","compounds":"(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (4S)-perillyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":26247,"RHEA_ID":23433,"DIRECTION":"LR","MASTER_ID":23432,"metacyc":"--LIMONENE-7-MONOOXYGENASE-RXN","compounds":"(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] => (4S)-perillyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":26248,"RHEA_ID":23434,"compounds":"(4S)-perillyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":26249,"RHEA_ID":44002,"compounds":"2-hydroxy-3-methylhexadecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + 3-methylhexadecanoyl-CoA + O2"}
{"X":26250,"RHEA_ID":23436,"compounds":"2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O = 2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate"}
{"X":26251,"RHEA_ID":23437,"compounds":"2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O => 2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate"}
{"X":26252,"RHEA_ID":23438,"compounds":"2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate => 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O"}
{"X":26253,"RHEA_ID":23439,"compounds":"2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O <=> 2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate"}
{"X":26254,"RHEA_ID":34068,"DIRECTION":"LR","MASTER_ID":34067,"metacyc":"RXN-11078","compounds":"5-phospho-alpha-D-ribose 1-diphosphate + H(+) + trans,octa-cis-decaprenyl phosphate => diphosphate + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose 5-phosphate"}
{"X":26255,"RHEA_ID":23441,"DIRECTION":"LR","MASTER_ID":23440,"metacyc":"4-CHLOROBENZOATE-DEHALOGENASE-RXN","compounds":"4-chlorobenzoate + H2O => 4-hydroxybenzoate + chloride + H(+)"}
{"X":26256,"RHEA_ID":23442,"compounds":"4-hydroxybenzoate + chloride + H(+) => 4-chlorobenzoate + H2O"}
{"X":26257,"RHEA_ID":34071,"DIRECTION":"UN","MASTER_ID":34071,"ec":"2.7.8.35","compounds":"trans,octa-cis-decaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol + UMP"}
{"X":26258,"RHEA_ID":23444,"DIRECTION":"UN","MASTER_ID":23444,"ec":"1.1.1.27","compounds":"(S)-lactate + NAD(+) = H(+) + NADH + pyruvate"}
{"X":26259,"RHEA_ID":23445,"DIRECTION":"LR","MASTER_ID":23444,"reactome":"R-HSA-70510.5","compounds":"(S)-lactate + NAD(+) => H(+) + NADH + pyruvate"}
{"X":26260,"RHEA_ID":23446,"DIRECTION":"RL","MASTER_ID":23444,"reactome":"R-HSA-6807826.2","compounds":"H(+) + NADH + pyruvate => (S)-lactate + NAD(+)"}
{"X":26261,"RHEA_ID":23446,"DIRECTION":"RL","MASTER_ID":23444,"reactome":"R-HSA-71849.6","compounds":"H(+) + NADH + pyruvate => (S)-lactate + NAD(+)"}
{"X":26262,"RHEA_ID":34076,"DIRECTION":"LR","MASTER_ID":34075,"metacyc":"RXN-9591","compounds":"an acyl phosphate + sn-glycerol 3-phosphate => a 1-acyl-sn-glycero-3-phosphate + phosphate"}
{"X":26263,"RHEA_ID":23448,"DIRECTION":"UN","MASTER_ID":23448,"ec":"2.7.7.38","compounds":"3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP = CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate"}
{"X":26264,"RHEA_ID":23449,"DIRECTION":"LR","MASTER_ID":23448,"ecocyc":"CPM-KDOSYNTH-RXN","metacyc":"CPM-KDOSYNTH-RXN","compounds":"3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP => CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate"}
{"X":26265,"RHEA_ID":23450,"compounds":"CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate => 3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP"}
{"X":26266,"RHEA_ID":44019,"compounds":"2,6,10,14-tetramethylpentadecanal + H2O + NAD(+) <=> 2,6,10,14-tetramethylpentadecanoate + 2 H(+) + NADH"}
{"X":26267,"RHEA_ID":23452,"DIRECTION":"UN","MASTER_ID":23452,"ec":"2.7.1.145","compounds":"2'-deoxyadenosine + ATP = ADP + dAMP + H(+)"}
{"X":26268,"RHEA_ID":23452,"DIRECTION":"UN","MASTER_ID":23452,"ec":"2.7.1.76","compounds":"2'-deoxyadenosine + ATP = ADP + dAMP + H(+)"}
{"X":26269,"RHEA_ID":23453,"DIRECTION":"LR","MASTER_ID":23452,"metacyc":"DEOXYADENOSINE-KINASE-RXN","compounds":"2'-deoxyadenosine + ATP => ADP + dAMP + H(+)"}
{"X":26270,"RHEA_ID":34084,"compounds":"a (3R)-hydroxyacyl-CoA => a (3S)-hydroxyacyl-CoA"}
{"X":26271,"RHEA_ID":34085,"compounds":"a (3S)-hydroxyacyl-CoA => a (3R)-hydroxyacyl-CoA"}
{"X":26272,"RHEA_ID":23456,"compounds":"(9Z,12Z)-octadecadienoate + AH2 + O2 = A + crepenynate + 2 H2O"}
{"X":26273,"RHEA_ID":23457,"compounds":"(9Z,12Z)-octadecadienoate + AH2 + O2 => A + crepenynate + 2 H2O"}
{"X":26274,"RHEA_ID":23458,"compounds":"A + crepenynate + 2 H2O => (9Z,12Z)-octadecadienoate + AH2 + O2"}
{"X":26275,"RHEA_ID":34089,"compounds":"a 1-acyl-sn-glycero-3-phosphocholine + a cholesterol ester => a 1,2-diacyl-sn-glycero-3-phosphocholine + cholesterol"}
{"X":26276,"RHEA_ID":23460,"DIRECTION":"UN","MASTER_ID":23460,"ec":"3.1.1.70","compounds":"benzyl cetraxate + H2O = benzyl alcohol + cetraxate + H(+)"}
{"X":26277,"RHEA_ID":23461,"DIRECTION":"LR","MASTER_ID":23460,"metacyc":"CETRAXATE-BENZYLESTERASE-RXN","compounds":"benzyl cetraxate + H2O => benzyl alcohol + cetraxate + H(+)"}
{"X":26278,"RHEA_ID":23462,"compounds":"benzyl alcohol + cetraxate + H(+) => benzyl cetraxate + H2O"}
{"X":26279,"RHEA_ID":34093,"compounds":"(S)-2-amino-6-oxohexanoate + NH4(+) + phosphate => (5R)-5-phosphooxy-L-lysine + H2O"}
{"X":26280,"RHEA_ID":23464,"DIRECTION":"UN","MASTER_ID":23464,"ec":"2.4.1.174","compounds":"3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP"}
{"X":26281,"RHEA_ID":23465,"DIRECTION":"LR","MASTER_ID":23464,"metacyc":"2.4.1.174-RXN","compounds":"3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine => 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP"}
{"X":26282,"RHEA_ID":34096,"DIRECTION":"LR","MASTER_ID":34095,"metacyc":"RXN-11564","compounds":"carboxyspermidine + H(+) => CO2 + spermidine"}
{"X":26283,"RHEA_ID":23468,"DIRECTION":"UN","MASTER_ID":23468,"ec":"1.14.12.14","compounds":"2-aminobenzenesulfonate + 2 H(+) + NADH + O2 = 2,3-dihydroxybenzenesulfonate + NAD(+) + NH4(+)"}
{"X":26284,"RHEA_ID":23469,"DIRECTION":"LR","MASTER_ID":23468,"metacyc":"2ASDOSALCAL-RXN","compounds":"2-aminobenzenesulfonate + 2 H(+) + NADH + O2 => 2,3-dihydroxybenzenesulfonate + NAD(+) + NH4(+)"}
{"X":26285,"RHEA_ID":34100,"DIRECTION":"LR","MASTER_ID":34099,"metacyc":"RXN-9380","compounds":"carboxynorspermidine + H(+) => CO2 + norspermidine"}
{"X":26286,"RHEA_ID":34101,"compounds":"CO2 + norspermidine => carboxynorspermidine + H(+)"}
{"X":26287,"RHEA_ID":23472,"DIRECTION":"UN","MASTER_ID":23472,"ec":"2.3.1.122","compounds":"2 alpha,alpha'-trehalose 6-mycolate = alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose"}
{"X":26288,"RHEA_ID":23473,"DIRECTION":"LR","MASTER_ID":23472,"metacyc":"RXN1G-874","compounds":"2 alpha,alpha'-trehalose 6-mycolate => alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose"}
{"X":26289,"RHEA_ID":34104,"DIRECTION":"LR","MASTER_ID":34103,"metacyc":"RXN-14572","compounds":"N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol => N-acetyl-alpha-D-galactosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol"}
{"X":26290,"RHEA_ID":34105,"compounds":"N-acetyl-alpha-D-galactosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol => N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol"}
{"X":26291,"RHEA_ID":23476,"DIRECTION":"UN","MASTER_ID":23476,"ec":"4.1.1.48","compounds":"1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O"}
{"X":26292,"RHEA_ID":23477,"DIRECTION":"LR","MASTER_ID":23476,"ecocyc":"IGPSYN-RXN","metacyc":"IGPSYN-RXN","compounds":"1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) => (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O"}
{"X":26293,"RHEA_ID":23478,"compounds":"(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O => 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)"}
{"X":26294,"RHEA_ID":34109,"compounds":"1-deoxymethyl-3-dehydrosphinganine + CO2 + CoA => glycine + H(+) + hexadecanoyl-CoA"}
{"X":26295,"RHEA_ID":23480,"DIRECTION":"UN","MASTER_ID":23480,"ec":"5.3.3.6","compounds":"2-methylene-3-methylsuccinate = dimethylmaleate"}
{"X":26296,"RHEA_ID":23481,"DIRECTION":"LR","MASTER_ID":23480,"metacyc":"METHYLITACONATE-DELTA-ISOMERASE-RXN","compounds":"2-methylene-3-methylsuccinate => dimethylmaleate"}
{"X":26297,"RHEA_ID":34112,"compounds":"carboxyspermidine + H2O + NADP(+) => H(+) + L-aspartate 4-semialdehyde + NADPH + putrescine"}
{"X":26298,"RHEA_ID":34113,"DIRECTION":"RL","MASTER_ID":34111,"metacyc":"RXN-11566","compounds":"H(+) + L-aspartate 4-semialdehyde + NADPH + putrescine => carboxyspermidine + H2O + NADP(+)"}
{"X":26299,"RHEA_ID":23484,"DIRECTION":"UN","MASTER_ID":23484,"ec":"1.1.99.18","compounds":"A + D-cellobiose = AH2 + D-cellobiono-1,5-lactone"}
{"X":26300,"RHEA_ID":23485,"compounds":"A + D-cellobiose => AH2 + D-cellobiono-1,5-lactone"}
{"X":26301,"RHEA_ID":23486,"compounds":"AH2 + D-cellobiono-1,5-lactone => A + D-cellobiose"}
{"X":26302,"RHEA_ID":44056,"compounds":"2-O-hexadecanoyl-alpha,alpha-trehalose + hexadecanoyl-CoA = 2-O,3-O-dihexadecanoyl-alpha,alpha-trehalose + CoA"}
{"X":26303,"RHEA_ID":23488,"DIRECTION":"UN","MASTER_ID":23488,"ec":"1.6.5.6","compounds":"1,4-benzoquinone + H(+) + NADPH = hydroquinone + NADP(+)"}
{"X":26304,"RHEA_ID":23489,"DIRECTION":"LR","MASTER_ID":23488,"metacyc":"1.6.5.6-RXN","compounds":"1,4-benzoquinone + H(+) + NADPH => hydroquinone + NADP(+)"}
{"X":26305,"RHEA_ID":23490,"compounds":"hydroquinone + NADP(+) => 1,4-benzoquinone + H(+) + NADPH"}
{"X":26306,"RHEA_ID":44060,"DIRECTION":"UN","MASTER_ID":44060,"ec":"2.3.1.288","compounds":"2-O-sulfo-alpha,alpha-trehalose + hexadecanoyl-CoA = 2-O-sulfo-2'-O-hexadecanoyl-alpha,alpha-trehalose + CoA"}
{"X":26307,"RHEA_ID":23492,"DIRECTION":"UN","MASTER_ID":23492,"ec":"5.1.3.16","metacyc":"UDP-GLUCOSAMINE-EPIMERASE-RXN","compounds":"UDP-alpha-D-glucosamine = UDP-alpha-D-galactosamine"}
{"X":26308,"RHEA_ID":23493,"compounds":"UDP-alpha-D-glucosamine => UDP-alpha-D-galactosamine"}
{"X":26309,"RHEA_ID":23494,"compounds":"UDP-alpha-D-galactosamine => UDP-alpha-D-glucosamine"}
{"X":26310,"RHEA_ID":34125,"compounds":"CoA + H(+) + olivetolate => 3,5,7-trioxododecanoyl-CoA"}
{"X":26311,"RHEA_ID":23496,"DIRECTION":"UN","MASTER_ID":23496,"ec":"2.8.3.14","metacyc":"5-HYDROXYPENTANOATE-COA-TRANSFERASE-RXN","compounds":"5-hydroxypentanoate + acetyl-CoA = 5-hydroxy-pentanoyl-CoA + acetate"}
{"X":26312,"RHEA_ID":23497,"compounds":"5-hydroxypentanoate + acetyl-CoA => 5-hydroxy-pentanoyl-CoA + acetate"}
{"X":26313,"RHEA_ID":23498,"compounds":"5-hydroxy-pentanoyl-CoA + acetate => 5-hydroxypentanoate + acetyl-CoA"}
{"X":26314,"RHEA_ID":44068,"compounds":"1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)"}
{"X":26315,"RHEA_ID":23500,"compounds":"H2O + N(6)-propanoyl-L-lysyl-[protein] + NAD(+) = 3''-O-propanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide"}
{"X":26316,"RHEA_ID":23501,"compounds":"H2O + N(6)-propanoyl-L-lysyl-[protein] + NAD(+) => 3''-O-propanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide"}
{"X":26317,"RHEA_ID":23502,"compounds":"3''-O-propanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-propanoyl-L-lysyl-[protein] + NAD(+)"}
{"X":26318,"RHEA_ID":34133,"compounds":"cannabinerolate + diphosphate => neryl diphosphate + olivetolate"}
{"X":26319,"RHEA_ID":23504,"DIRECTION":"UN","MASTER_ID":23504,"ec":"3.5.1.90","compounds":"adenosylcob(III)inamide + H2O = (R)-1-aminopropan-2-ol + adenosylcob(III)yrate"}
{"X":26320,"RHEA_ID":23505,"DIRECTION":"LR","MASTER_ID":23504,"metacyc":"R346-RXN","compounds":"adenosylcob(III)inamide + H2O => (R)-1-aminopropan-2-ol + adenosylcob(III)yrate"}
{"X":26321,"RHEA_ID":23506,"compounds":"(R)-1-aminopropan-2-ol + adenosylcob(III)yrate => adenosylcob(III)inamide + H2O"}
{"X":26322,"RHEA_ID":34137,"compounds":"Delta(9)-tetrahydrocannabinolate + H2O2 => cannabigerolate + O2"}
{"X":26323,"RHEA_ID":23508,"DIRECTION":"UN","MASTER_ID":23508,"ec":"3.5.1.93","compounds":"(7R)-7-(4-carboxybutanamido)cephalosporanate + H2O = (7R)-7-aminocephalosporanate + glutarate"}
{"X":26324,"RHEA_ID":23509,"compounds":"(7R)-7-(4-carboxybutanamido)cephalosporanate + H2O => (7R)-7-aminocephalosporanate + glutarate"}
{"X":26325,"RHEA_ID":23510,"compounds":"(7R)-7-aminocephalosporanate + glutarate => (7R)-7-(4-carboxybutanamido)cephalosporanate + H2O"}
{"X":26326,"RHEA_ID":34141,"compounds":"CO2 + Delta(9)-tetrahydrocannabinol => Delta(9)-tetrahydrocannabinolate + H(+)"}
{"X":26327,"RHEA_ID":23512,"DIRECTION":"UN","MASTER_ID":23512,"ec":"2.4.1.64","compounds":"alpha,alpha-trehalose + phosphate = beta-D-glucose 1-phosphate + D-glucose"}
{"X":26328,"RHEA_ID":23513,"compounds":"alpha,alpha-trehalose + phosphate => beta-D-glucose 1-phosphate + D-glucose"}
{"X":26329,"RHEA_ID":23514,"compounds":"beta-D-glucose 1-phosphate + D-glucose => alpha,alpha-trehalose + phosphate"}
{"X":26330,"RHEA_ID":44084,"compounds":"ATP + CoA + heptadecanoate = AMP + diphosphate + heptadecanoyl-CoA"}
{"X":26331,"RHEA_ID":23516,"DIRECTION":"UN","MASTER_ID":23516,"ec":"2.7.1.31","compounds":"(R)-glycerate + ATP = (2R)-3-phosphoglycerate + ADP + H(+)"}
{"X":26332,"RHEA_ID":23517,"DIRECTION":"LR","MASTER_ID":23516,"ecocyc":"GLY3KIN-RXN","metacyc":"GLY3KIN-RXN","reactome":"R-HSA-6799495.1","compounds":"(R)-glycerate + ATP => (2R)-3-phosphoglycerate + ADP + H(+)"}
{"X":26333,"RHEA_ID":23518,"compounds":"(2R)-3-phosphoglycerate + ADP + H(+) => (R)-glycerate + ATP"}
{"X":26334,"RHEA_ID":44088,"compounds":"ATP + CoA + heptanoate = AMP + diphosphate + heptanoyl-CoA"}
{"X":26335,"RHEA_ID":23520,"DIRECTION":"UN","MASTER_ID":23520,"ec":"2.8.3.1","compounds":"acetyl-CoA + propanoate = acetate + propanoyl-CoA"}
{"X":26336,"RHEA_ID":23521,"compounds":"acetyl-CoA + propanoate => acetate + propanoyl-CoA"}
{"X":26337,"RHEA_ID":23522,"compounds":"acetate + propanoyl-CoA => acetyl-CoA + propanoate"}
{"X":26338,"RHEA_ID":44092,"compounds":"ATP + CoA + nonadecanoate = AMP + diphosphate + nonadecanoyl-CoA"}
{"X":26339,"RHEA_ID":23524,"DIRECTION":"UN","MASTER_ID":23524,"ec":"2.3.1.152","metacyc":"2.3.1.152-RXN","compounds":"1-O-(trans-cinnamoyl)-beta-D-glucose + an alcohol = an alkyl cinnamate + beta-D-glucose"}
{"X":26340,"RHEA_ID":23525,"compounds":"1-O-(trans-cinnamoyl)-beta-D-glucose + an alcohol => an alkyl cinnamate + beta-D-glucose"}
{"X":26341,"RHEA_ID":23526,"compounds":"an alkyl cinnamate + beta-D-glucose => 1-O-(trans-cinnamoyl)-beta-D-glucose + an alcohol"}
{"X":26342,"RHEA_ID":44096,"compounds":"decan-1-ol + hexadecanoyl-CoA = CoA + decanyl hexadecanoate"}
{"X":26343,"RHEA_ID":23528,"compounds":"citramalate + succinyl-CoA = citramalyl-CoA + succinate"}
{"X":26344,"RHEA_ID":23529,"compounds":"citramalate + succinyl-CoA => citramalyl-CoA + succinate"}
{"X":26345,"RHEA_ID":23530,"compounds":"citramalyl-CoA + succinate => citramalate + succinyl-CoA"}
{"X":26346,"RHEA_ID":34161,"compounds":"CoA + H(+) + UDP-N,N'-diacetylbacillosamine => acetyl-CoA + UDP-N-acetylbacillosamine"}
{"X":26347,"RHEA_ID":23532,"DIRECTION":"UN","MASTER_ID":23532,"ec":"6.2.1.7","compounds":"ATP + cholate + CoA = AMP + choloyl-CoA + diphosphate"}
{"X":26348,"RHEA_ID":23533,"DIRECTION":"LR","MASTER_ID":23532,"metacyc":"CHOLATE--COA-LIGASE-RXN","compounds":"ATP + cholate + CoA => AMP + choloyl-CoA + diphosphate"}
{"X":26349,"RHEA_ID":23534,"compounds":"AMP + choloyl-CoA + diphosphate => ATP + cholate + CoA"}
{"X":26350,"RHEA_ID":44104,"compounds":"decanal + H2O + NAD(+) = decanoate + 2 H(+) + NADH"}
{"X":26351,"RHEA_ID":23536,"DIRECTION":"UN","MASTER_ID":23536,"ec":"5.4.2.2","compounds":"alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate"}
{"X":26352,"RHEA_ID":23536,"DIRECTION":"UN","MASTER_ID":23536,"ec":"5.4.2.5","compounds":"alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate"}
{"X":26353,"RHEA_ID":23537,"DIRECTION":"LR","MASTER_ID":23536,"metacyc":"5.4.2.5-RXN","compounds":"alpha-D-glucose 1-phosphate => alpha-D-glucose 6-phosphate"}
{"X":26354,"RHEA_ID":34169,"compounds":"2,6-dihydroxypyridine + 4-(methylamino)butanoate + H(+) => 2,6-dihydroxypseudooxynicotine + H2O"}
{"X":26355,"RHEA_ID":44109,"compounds":"H2O + heptanal + NAD(+) => 2 H(+) + heptanoate + NADH"}
{"X":26356,"RHEA_ID":23540,"DIRECTION":"UN","MASTER_ID":23540,"ec":"6.1.1.17","compounds":"ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)"}
{"X":26357,"RHEA_ID":23541,"DIRECTION":"LR","MASTER_ID":23540,"ecocyc":"GLURS-RXN","metacyc":"GLURS-RXN","compounds":"ATP + L-glutamate + tRNA(Glu) => AMP + diphosphate + L-glutamyl-tRNA(Glu)"}
{"X":26358,"RHEA_ID":34173,"compounds":"(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O => L-aspartate 4-semialdehyde + pyruvate"}
{"X":26359,"RHEA_ID":44113,"compounds":"hexadecanoyl-CoA + nonan-1-ol => CoA + nonyl hexadecanoate"}
{"X":26360,"RHEA_ID":23544,"DIRECTION":"UN","MASTER_ID":23544,"ec":"2.4.1.240","compounds":"a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-alpha-D-glucose = a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP"}
{"X":26361,"RHEA_ID":23545,"DIRECTION":"LR","MASTER_ID":23544,"metacyc":"2.4.1.240-RXN","compounds":"a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-alpha-D-glucose => a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP"}
{"X":26362,"RHEA_ID":34177,"compounds":"4-hydroxycoumarin + CO2 + 2 CoA => 2-hydroxybenzoyl-CoA + malonyl-CoA"}
{"X":26363,"RHEA_ID":44117,"compounds":"eicosan-1-ol + hexadecanoyl-CoA => CoA + eicosanyl hexadecanoate"}
{"X":26364,"RHEA_ID":23548,"DIRECTION":"UN","MASTER_ID":23548,"ec":"2.1.1.171","compounds":"guanosine(966) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine"}
{"X":26365,"RHEA_ID":23549,"DIRECTION":"LR","MASTER_ID":23548,"ecocyc":"RXN0-6515","metacyc":"RXN0-6515","compounds":"guanosine(966) in 16S rRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine"}
{"X":26366,"RHEA_ID":23550,"compounds":"H(+) + N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine => guanosine(966) in 16S rRNA + S-adenosyl-L-methionine"}
{"X":26367,"RHEA_ID":44121,"compounds":"hexadecanoyl-CoA + octadecan-1-ol => CoA + octadecanyl hexadecanoate"}
{"X":26368,"RHEA_ID":23552,"DIRECTION":"UN","MASTER_ID":23552,"ec":"1.1.1.400","compounds":"2-methylpropane-1,2-diol + NAD(+) = 2-hydroxy-2-methylpropanal + H(+) + NADH"}
{"X":26369,"RHEA_ID":23553,"DIRECTION":"LR","MASTER_ID":23552,"metacyc":"RXN-17602","compounds":"2-methylpropane-1,2-diol + NAD(+) => 2-hydroxy-2-methylpropanal + H(+) + NADH"}
{"X":26370,"RHEA_ID":23554,"compounds":"2-hydroxy-2-methylpropanal + H(+) + NADH => 2-methylpropane-1,2-diol + NAD(+)"}
{"X":26371,"RHEA_ID":23556,"DIRECTION":"UN","MASTER_ID":23556,"ec":"2.3.2.14","compounds":"D-alanine + L-glutamine = gamma-L-glutamyl-D-alanine + NH4(+)"}
{"X":26372,"RHEA_ID":23557,"DIRECTION":"LR","MASTER_ID":23556,"metacyc":"D-ALANINE-GAMMA-GLUTAMYLTRANSFERASE-RXN","compounds":"D-alanine + L-glutamine => gamma-L-glutamyl-D-alanine + NH4(+)"}
{"X":26373,"RHEA_ID":23558,"compounds":"gamma-L-glutamyl-D-alanine + NH4(+) => D-alanine + L-glutamine"}
{"X":26374,"RHEA_ID":54105,"DIRECTION":"LR","MASTER_ID":54104,"metacyc":"RXN-15120","compounds":"N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":26375,"RHEA_ID":23560,"DIRECTION":"UN","MASTER_ID":23560,"ec":"2.7.8.26","compounds":"adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)"}
{"X":26376,"RHEA_ID":23561,"DIRECTION":"LR","MASTER_ID":23560,"ecocyc":"COBALAMIN5PSYN-RXN","metacyc":"COBALAMIN5PSYN-RXN","compounds":"adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate => adenosylcob(III)alamin 5'-phosphate + GMP + H(+)"}
{"X":26377,"RHEA_ID":23562,"compounds":"adenosylcob(III)alamin 5'-phosphate + GMP + H(+) => adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate"}
{"X":26378,"RHEA_ID":44133,"compounds":"2 S-adenosyl 3-(methylsulfanyl)propylamine + spermidine => 2 H(+) + N(4)-bis(aminopropyl)spermidine + 2 S-methyl-5'-thioadenosine"}
{"X":26379,"RHEA_ID":23564,"DIRECTION":"UN","MASTER_ID":23564,"ec":"1.21.3.2","compounds":"2 columbamine + O2 = 2 berberine + 2 H2O"}
{"X":26380,"RHEA_ID":23565,"DIRECTION":"LR","MASTER_ID":23564,"metacyc":"COLUMBAMINE-OXIDASE-RXN","compounds":"2 columbamine + O2 => 2 berberine + 2 H2O"}
{"X":26381,"RHEA_ID":23566,"compounds":"2 berberine + 2 H2O => 2 columbamine + O2"}
{"X":26382,"RHEA_ID":54113,"DIRECTION":"LR","MASTER_ID":54112,"metacyc":"RXN-18886","compounds":"(2E,6E)-farnesyl diphosphate => diphosphate + selina-4(15),7(11)-diene"}
{"X":26383,"RHEA_ID":23568,"DIRECTION":"UN","MASTER_ID":23568,"ec":"5.3.3.14","compounds":"(2E)-decenoyl-[ACP] = (3Z)-decenoyl-[ACP]"}
{"X":26384,"RHEA_ID":23569,"compounds":"(2E)-decenoyl-[ACP] => (3Z)-decenoyl-[ACP]"}
{"X":26385,"RHEA_ID":23570,"compounds":"(3Z)-decenoyl-[ACP] => (2E)-decenoyl-[ACP]"}
{"X":26386,"RHEA_ID":44141,"compounds":"CoA + 2 H(+) + oxidized [flavodoxin] + pyruvate => acetyl-CoA + CO2 + reduced [flavodoxin]"}
{"X":26387,"RHEA_ID":23572,"DIRECTION":"UN","MASTER_ID":23572,"ec":"2.3.1.156","compounds":"3-methylbutanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 3 CO2 + 4 CoA + phlorisovalerophenone"}
{"X":26388,"RHEA_ID":23573,"DIRECTION":"LR","MASTER_ID":23572,"metacyc":"2.3.1.156-RXN","compounds":"3-methylbutanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 3 CO2 + 4 CoA + phlorisovalerophenone"}
{"X":26389,"RHEA_ID":23574,"compounds":"3 CO2 + 4 CoA + phlorisovalerophenone => 3-methylbutanoyl-CoA + 3 H(+) + 3 malonyl-CoA"}
{"X":26390,"RHEA_ID":54121,"DIRECTION":"LR","MASTER_ID":54120,"metacyc":"RXN-18875","compounds":"coelenterazine h + O2 => coelenterazine h dioxetanone"}
{"X":26391,"RHEA_ID":23576,"DIRECTION":"UN","MASTER_ID":23576,"ec":"1.14.19.66","compounds":"(R)-N-methylcoclaurine + (S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase] = berbamunine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":26392,"RHEA_ID":23577,"DIRECTION":"LR","MASTER_ID":23576,"metacyc":"1.1.3.34-RXN","compounds":"(R)-N-methylcoclaurine + (S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase] => berbamunine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":26393,"RHEA_ID":23578,"compounds":"berbamunine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (R)-N-methylcoclaurine + (S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":26394,"RHEA_ID":54125,"DIRECTION":"LR","MASTER_ID":54124,"metacyc":"RXN-18866","compounds":"coelenterazine h dioxetanone => CO2 + excited coelenteramide h monoanion + H(+)"}
{"X":26395,"RHEA_ID":23580,"DIRECTION":"UN","MASTER_ID":23580,"ec":"5.3.99.4","compounds":"prostaglandin H2 = prostaglandin I2"}
{"X":26396,"RHEA_ID":23581,"DIRECTION":"LR","MASTER_ID":23580,"metacyc":"PROSTAGLANDIN-I-SYNTHASE-RXN","reactome":"R-HSA-76496.2","compounds":"prostaglandin H2 => prostaglandin I2"}
{"X":26397,"RHEA_ID":23582,"compounds":"prostaglandin I2 => prostaglandin H2"}
{"X":26398,"RHEA_ID":44153,"DIRECTION":"LR","MASTER_ID":44152,"metacyc":"RXN-7253","compounds":"1D-myo-inositol 2-phosphate + H2O => myo-inositol + phosphate"}
{"X":26399,"RHEA_ID":23584,"DIRECTION":"UN","MASTER_ID":23584,"ec":"6.3.2.12","compounds":"7,8-dihydropteroate + ATP + L-glutamate = 7,8-dihydrofolate + ADP + H(+) + phosphate"}
{"X":26400,"RHEA_ID":23585,"DIRECTION":"LR","MASTER_ID":23584,"ecocyc":"DIHYDROFOLATESYNTH-RXN","metacyc":"DIHYDROFOLATESYNTH-RXN","compounds":"7,8-dihydropteroate + ATP + L-glutamate => 7,8-dihydrofolate + ADP + H(+) + phosphate"}
{"X":26401,"RHEA_ID":23586,"compounds":"7,8-dihydrofolate + ADP + H(+) + phosphate => 7,8-dihydropteroate + ATP + L-glutamate"}
{"X":26402,"RHEA_ID":44157,"DIRECTION":"LR","MASTER_ID":44156,"metacyc":"RXN-10953","compounds":"1D-myo-inositol 5-phosphate + H2O => myo-inositol + phosphate"}
{"X":26403,"RHEA_ID":23588,"DIRECTION":"UN","MASTER_ID":23588,"ec":"2.8.3.2","compounds":"oxalate + succinyl-CoA = oxalyl-CoA + succinate"}
{"X":26404,"RHEA_ID":23589,"compounds":"oxalate + succinyl-CoA => oxalyl-CoA + succinate"}
{"X":26405,"RHEA_ID":23590,"compounds":"oxalyl-CoA + succinate => oxalate + succinyl-CoA"}
{"X":26406,"RHEA_ID":54137,"compounds":"cytidine(48) in tRNA precursor + S-adenosyl-L-methionine => 5-methylcytidine(48) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine"}
{"X":26407,"RHEA_ID":23592,"DIRECTION":"UN","MASTER_ID":23592,"ec":"1.1.1.72","compounds":"glycerol + NADP(+) = D-glyceraldehyde + H(+) + NADPH"}
{"X":26408,"RHEA_ID":23592,"DIRECTION":"UN","MASTER_ID":23592,"ec":"1.1.1.372","compounds":"glycerol + NADP(+) = D-glyceraldehyde + H(+) + NADPH"}
{"X":26409,"RHEA_ID":23593,"compounds":"glycerol + NADP(+) => D-glyceraldehyde + H(+) + NADPH"}
{"X":26410,"RHEA_ID":44165,"compounds":"ATP + H2O => adenine + D-ribose 5-triphosphate"}
{"X":26411,"RHEA_ID":23596,"DIRECTION":"UN","MASTER_ID":23596,"ec":"1.1.1.22","compounds":"H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate"}
{"X":26412,"RHEA_ID":23597,"DIRECTION":"LR","MASTER_ID":23596,"ecocyc":"UGD-RXN","metacyc":"UGD-RXN","compounds":"H2O + 2 NAD(+) + UDP-alpha-D-glucose => 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate"}
{"X":26413,"RHEA_ID":23598,"compounds":"3 H(+) + 2 NADH + UDP-alpha-D-glucuronate => H2O + 2 NAD(+) + UDP-alpha-D-glucose"}
{"X":26414,"RHEA_ID":34231,"compounds":"5-nitrosalicylate + O2 = 4-nitro-6-oxohepta-2,4-dienedioate + H(+)"}
{"X":26415,"RHEA_ID":23600,"DIRECTION":"UN","MASTER_ID":23600,"ec":"2.6.1.67","compounds":"2-oxoglutarate + L-2-aminohexanoate = 2-oxohexanoate + L-glutamate"}
{"X":26416,"RHEA_ID":23601,"compounds":"2-oxoglutarate + L-2-aminohexanoate => 2-oxohexanoate + L-glutamate"}
{"X":26417,"RHEA_ID":44173,"compounds":"H2O + NAD(+) + tetradecanal => 2 H(+) + NADH + tetradecanoate"}
{"X":26418,"RHEA_ID":34235,"compounds":"4-nitro-6-oxohepta-2,4-dienedioate = 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + nitrite"}
{"X":26419,"RHEA_ID":23604,"DIRECTION":"UN","MASTER_ID":23604,"ec":"4.2.1.95","compounds":"kievitone hydrate = H2O + kievitone"}
{"X":26420,"RHEA_ID":23605,"compounds":"kievitone hydrate => H2O + kievitone"}
{"X":26421,"RHEA_ID":23606,"DIRECTION":"RL","MASTER_ID":23604,"metacyc":"KIEVITONE-HYDRATASE-RXN","compounds":"H2O + kievitone => kievitone hydrate"}
{"X":26422,"RHEA_ID":34239,"DIRECTION":"UN","MASTER_ID":34239,"ec":"5.4.3.9","compounds":"L-glutamate = 3-aminopentanedioate"}
{"X":26423,"RHEA_ID":23608,"DIRECTION":"UN","MASTER_ID":23608,"ec":"3.5.4.42","compounds":"H(+) + H2O + N-isopropylammelide = cyanurate + isopropylamine"}
{"X":26424,"RHEA_ID":23609,"DIRECTION":"LR","MASTER_ID":23608,"metacyc":"R123-RXN","compounds":"H(+) + H2O + N-isopropylammelide => cyanurate + isopropylamine"}
{"X":26425,"RHEA_ID":44181,"compounds":"2-methylpropanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":26426,"RHEA_ID":34243,"DIRECTION":"UN","MASTER_ID":34243,"ec":"2.7.7.77","compounds":"GTP + H(+) + Mo-molybdopterin = diphosphate + Mo-molybdopterin guanine dinucleotide"}
{"X":26427,"RHEA_ID":23612,"DIRECTION":"UN","MASTER_ID":23612,"ec":"1.3.1.47","metacyc":"ALPHA-SANTONIN-12-REDUCTASE-RXN","compounds":"1,2-dihydro-alpha-santonin + NAD(+) = alpha-santonin + H(+) + NADH"}
{"X":26428,"RHEA_ID":23613,"compounds":"1,2-dihydro-alpha-santonin + NAD(+) => alpha-santonin + H(+) + NADH"}
{"X":26429,"RHEA_ID":23614,"compounds":"alpha-santonin + H(+) + NADH => 1,2-dihydro-alpha-santonin + NAD(+)"}
{"X":26430,"RHEA_ID":34247,"compounds":"1-deoxymethyl-sphinganine + NADP(+) = 1-deoxymethyl-3-dehydrosphinganine + H(+) + NADPH"}
{"X":26431,"RHEA_ID":23616,"DIRECTION":"UN","MASTER_ID":23616,"ec":"1.3.1.47","metacyc":"ALPHA-SANTONIN-12-REDUCTASE-RXN","compounds":"1,2-dihydro-alpha-santonin + NADP(+) = alpha-santonin + H(+) + NADPH"}
{"X":26432,"RHEA_ID":23617,"compounds":"1,2-dihydro-alpha-santonin + NADP(+) => alpha-santonin + H(+) + NADPH"}
{"X":26433,"RHEA_ID":23618,"compounds":"alpha-santonin + H(+) + NADPH => 1,2-dihydro-alpha-santonin + NADP(+)"}
{"X":26434,"RHEA_ID":34251,"compounds":"1-deoxysphinganine + NADP(+) = 1-deoxy-3-dehydrosphinganine + H(+) + NADPH"}
{"X":26435,"RHEA_ID":23620,"DIRECTION":"UN","MASTER_ID":23620,"ec":"6.3.3.4","compounds":"ATP + N(2)-(2-carboxyethyl)-L-arginine = AMP + deoxyamidinoproclavaminate + diphosphate + H(+)"}
{"X":26436,"RHEA_ID":23621,"DIRECTION":"LR","MASTER_ID":23620,"macie":"M0303","metacyc":"6.3.3.4-RXN","compounds":"ATP + N(2)-(2-carboxyethyl)-L-arginine => AMP + deoxyamidinoproclavaminate + diphosphate + H(+)"}
{"X":26437,"RHEA_ID":34254,"compounds":"1-deoxysphinganine + NADP(+) <=> 1-deoxy-3-dehydrosphinganine + H(+) + NADPH"}
{"X":26438,"RHEA_ID":34255,"DIRECTION":"UN","MASTER_ID":34255,"ec":"4.2.1.137","compounds":"sporulenol = H2O + tetraprenyl-beta-curcumene"}
{"X":26439,"RHEA_ID":23624,"compounds":"a 5,6-dihydrouridine in tRNA + NADP(+) = a uridine in tRNA + H(+) + NADPH"}
{"X":26440,"RHEA_ID":23625,"compounds":"a 5,6-dihydrouridine in tRNA + NADP(+) => a uridine in tRNA + H(+) + NADPH"}
{"X":26441,"RHEA_ID":44197,"compounds":"3-methylundecanoate + ATP + CoA => 3-methylundecanoyl-CoA + AMP + diphosphate"}
{"X":26442,"RHEA_ID":23627,"compounds":"a 5,6-dihydrouridine in tRNA + NADP(+) <=> a uridine in tRNA + H(+) + NADPH"}
{"X":26443,"RHEA_ID":23628,"DIRECTION":"UN","MASTER_ID":23628,"ec":"2.4.1.65","compounds":"a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)"}
{"X":26444,"RHEA_ID":23629,"DIRECTION":"LR","MASTER_ID":23628,"metacyc":"2.4.1.65-RXN","compounds":"a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose => a beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)"}
{"X":26445,"RHEA_ID":44201,"compounds":"12-methyloctadecanoate + ATP + CoA => 12-methyloctadecanoyl-CoA + AMP + diphosphate"}
{"X":26446,"RHEA_ID":34263,"DIRECTION":"UN","MASTER_ID":34263,"ec":"2.5.1.100","compounds":"dimethylallyl diphosphate + fumigaclavine A = diphosphate + fumigaclavine C"}
{"X":26447,"RHEA_ID":23632,"DIRECTION":"UN","MASTER_ID":23632,"ec":"1.1.1.286","compounds":"D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH"}
{"X":26448,"RHEA_ID":23632,"DIRECTION":"UN","MASTER_ID":23632,"ec":"1.1.1.41","compounds":"D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH"}
{"X":26449,"RHEA_ID":44205,"compounds":"2-hydroxyhexadecanoate + ATP + CoA => 2-hydroxyhexadecanoyl-CoA + AMP + diphosphate"}
{"X":26450,"RHEA_ID":23633,"DIRECTION":"LR","MASTER_ID":23632,"metacyc":"ISOCITRATE-DEHYDROGENASE-NAD%2b-RXN","reactome":"R-HSA-70967.4","compounds":"D-threo-isocitrate + NAD(+) => 2-oxoglutarate + CO2 + NADH"}
{"X":26451,"RHEA_ID":23634,"compounds":"2-oxoglutarate + CO2 + NADH => D-threo-isocitrate + NAD(+)"}
{"X":26452,"RHEA_ID":34269,"compounds":"CoA + fumigaclavine A => acetyl-CoA + fumigaclavine B"}
{"X":26453,"RHEA_ID":44209,"compounds":"12-methyltridecanoate + ATP + CoA => 12-methyltridecanoyl-CoA + AMP + diphosphate"}
{"X":26454,"RHEA_ID":23641,"DIRECTION":"LR","MASTER_ID":23640,"metacyc":"ETHYL-RXN","compounds":"1-aminocyclopropane-1-carboxylate + L-ascorbate + O2 => CO2 + ethene + 2 H2O + hydrogen cyanide + L-dehydroascorbate"}
{"X":26455,"RHEA_ID":23642,"compounds":"CO2 + ethene + 2 H2O + hydrogen cyanide + L-dehydroascorbate => 1-aminocyclopropane-1-carboxylate + L-ascorbate + O2"}
{"X":26456,"RHEA_ID":34273,"compounds":"1,3-dihydro-2H-imidazol-2-one + H(+) + nitrite => 2-nitroimidazole + H2O"}
{"X":26457,"RHEA_ID":23644,"DIRECTION":"UN","MASTER_ID":23644,"ec":"1.14.14.57","compounds":"lithocholate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + hyodeoxycholate + oxidized [NADPH--hemoprotein reductase]"}
{"X":26458,"RHEA_ID":34275,"DIRECTION":"UN","MASTER_ID":34275,"ec":"1.1.99.38","compounds":"2-deoxy-scyllo-inosamine + S-adenosyl-L-methionine = 3-amino-2,3-dideoxy-scyllo-inosose + 5'-deoxyadenosine + H(+) + L-methionine"}
{"X":26459,"RHEA_ID":23646,"compounds":"H(+) + H2O + hyodeoxycholate + oxidized [NADPH--hemoprotein reductase] => lithocholate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":26460,"RHEA_ID":34277,"compounds":"3-amino-2,3-dideoxy-scyllo-inosose + 5'-deoxyadenosine + H(+) + L-methionine => 2-deoxy-scyllo-inosamine + S-adenosyl-L-methionine"}
{"X":26461,"RHEA_ID":23648,"DIRECTION":"UN","MASTER_ID":23648,"ec":"1.1.1.134","metacyc":"1.1.1.134-RXN","compounds":"dTDP-6-deoxy-beta-L-talose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH"}
{"X":26462,"RHEA_ID":23648,"DIRECTION":"UN","MASTER_ID":23648,"ec":"1.1.1.134","metacyc":"RXN-14184","compounds":"dTDP-6-deoxy-beta-L-talose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH"}
{"X":26463,"RHEA_ID":34280,"compounds":"di-trans,poly-cis-dolichol + NADP(+) => di-trans,cis-polyprenol + H(+) + NADPH"}
{"X":26464,"RHEA_ID":23648,"DIRECTION":"UN","MASTER_ID":23648,"ec":"1.1.1.344","metacyc":"RXN-14184","compounds":"dTDP-6-deoxy-beta-L-talose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH"}
{"X":26465,"RHEA_ID":23649,"compounds":"dTDP-6-deoxy-beta-L-talose + NADP(+) => dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH"}
{"X":26466,"RHEA_ID":23650,"compounds":"dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH => dTDP-6-deoxy-beta-L-talose + NADP(+)"}
{"X":26467,"RHEA_ID":44223,"compounds":"15-hydroxypentadecanoate + ATP + CoA <=> 15-hydroxypentadecanoyl-CoA + AMP + diphosphate"}
{"X":26468,"RHEA_ID":23652,"DIRECTION":"UN","MASTER_ID":23652,"ec":"2.3.2.5","compounds":"N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+)"}
{"X":26469,"RHEA_ID":23653,"compounds":"N-terminal L-glutaminyl-[peptide] => N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+)"}
{"X":26470,"RHEA_ID":23654,"compounds":"N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+) => N-terminal L-glutaminyl-[peptide]"}
{"X":26471,"RHEA_ID":34288,"DIRECTION":"LR","MASTER_ID":34287,"metacyc":"RXN-13061","reactome":"R-HSA-5662692.1","compounds":"2 L-dopa + O2 => 2 H2O + 2 L-dopaquinone"}
{"X":26472,"RHEA_ID":23656,"DIRECTION":"UN","MASTER_ID":23656,"ec":"5.5.1.2","compounds":"2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate = 3-carboxy-cis,cis-muconate + H(+)"}
{"X":26473,"RHEA_ID":23657,"compounds":"2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate => 3-carboxy-cis,cis-muconate + H(+)"}
{"X":26474,"RHEA_ID":23658,"DIRECTION":"RL","MASTER_ID":23656,"metacyc":"5.5.1.2-RXN","compounds":"3-carboxy-cis,cis-muconate + H(+) => 2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate"}
{"X":26475,"RHEA_ID":34292,"DIRECTION":"LR","MASTER_ID":34291,"metacyc":"RXN-8453","compounds":"2',4,4',6'-tetrahydroxychalcone + UDP-alpha-D-glucose => 2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP"}
{"X":26476,"RHEA_ID":23660,"DIRECTION":"UN","MASTER_ID":23660,"ec":"3.5.2.7","compounds":"4-imidazolone-5-propanoate + H2O = N-formimidoyl-L-glutamate"}
{"X":26477,"RHEA_ID":23661,"DIRECTION":"LR","MASTER_ID":23660,"metacyc":"IMIDAZOLONEPROPIONASE-RXN","reactome":"R-HSA-70906.2","compounds":"4-imidazolone-5-propanoate + H2O => N-formimidoyl-L-glutamate"}
{"X":26478,"RHEA_ID":23662,"compounds":"N-formimidoyl-L-glutamate => 4-imidazolone-5-propanoate + H2O"}
{"X":26479,"RHEA_ID":44235,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":26480,"RHEA_ID":23664,"DIRECTION":"UN","MASTER_ID":23664,"ec":"1.1.99.30","compounds":"A + a (2R)-2-hydroxycarboxylate = a 2-oxocarboxylate + AH2"}
{"X":26481,"RHEA_ID":23665,"compounds":"A + a (2R)-2-hydroxycarboxylate => a 2-oxocarboxylate + AH2"}
{"X":26482,"RHEA_ID":23666,"compounds":"a 2-oxocarboxylate + AH2 => A + a (2R)-2-hydroxycarboxylate"}
{"X":26483,"RHEA_ID":34300,"compounds":"2'-deamino-2'-hydroxyneamine + 2-oxoglutarate => 2'-deamino-2'-hydroxy-6'-dehydroparomamine + L-glutamate"}
{"X":26484,"RHEA_ID":23668,"DIRECTION":"UN","MASTER_ID":23668,"ec":"6.3.4.9","compounds":"apo-[methylmalonyl-CoA:pyruvate carboxytransferase] + ATP + biotin = AMP + diphosphate + H(+) + holo-[methylmalonyl-CoA:pyruvate carboxytransferase]"}
{"X":26485,"RHEA_ID":23669,"compounds":"apo-[methylmalonyl-CoA:pyruvate carboxytransferase] + ATP + biotin => AMP + diphosphate + H(+) + holo-[methylmalonyl-CoA:pyruvate carboxytransferase]"}
{"X":26486,"RHEA_ID":23670,"compounds":"AMP + diphosphate + H(+) + holo-[methylmalonyl-CoA:pyruvate carboxytransferase] => apo-[methylmalonyl-CoA:pyruvate carboxytransferase] + ATP + biotin"}
{"X":26487,"RHEA_ID":44243,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol <=> a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + di-(9Z)-octadecenoylglycerol"}
{"X":26488,"RHEA_ID":23672,"DIRECTION":"UN","MASTER_ID":23672,"ec":"1.1.5.8","compounds":"a quinone + L-quinate = 3-dehydroquinate + a quinol"}
{"X":26489,"RHEA_ID":23673,"DIRECTION":"LR","MASTER_ID":23672,"metacyc":"1.1.99.25-RXN","compounds":"a quinone + L-quinate => 3-dehydroquinate + a quinol"}
{"X":26490,"RHEA_ID":23674,"compounds":"3-dehydroquinate + a quinol => a quinone + L-quinate"}
{"X":26491,"RHEA_ID":34308,"DIRECTION":"LR","MASTER_ID":34307,"metacyc":"RXN-11965","compounds":"4-nitrocatechol + NADPH + O2 => 2-hydroxy-1,4-benzoquinone + H2O + NADP(+) + nitrite"}
{"X":26492,"RHEA_ID":23676,"DIRECTION":"UN","MASTER_ID":23676,"ec":"6.3.2.13","compounds":"ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate"}
{"X":26493,"RHEA_ID":23677,"DIRECTION":"LR","MASTER_ID":23676,"ecocyc":"UDP-NACMURALGLDAPLIG-RXN","metacyc":"UDP-NACMURALGLDAPLIG-RXN","compounds":"ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate"}
{"X":26494,"RHEA_ID":23678,"compounds":"ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate => ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate"}
{"X":26495,"RHEA_ID":34312,"DIRECTION":"LR","MASTER_ID":34311,"metacyc":"RXN-11965","compounds":"4-nitrocatechol + NADH + O2 => 2-hydroxy-1,4-benzoquinone + H2O + NAD(+) + nitrite"}
{"X":26496,"RHEA_ID":34313,"compounds":"2-hydroxy-1,4-benzoquinone + H2O + NAD(+) + nitrite => 4-nitrocatechol + NADH + O2"}
{"X":26497,"RHEA_ID":23681,"DIRECTION":"LR","MASTER_ID":23680,"metacyc":"NUCLEOSIDE-TRIPHOSPHATASE-RXN","compounds":"a ribonucleoside 5'-triphosphate + H2O => a ribonucleoside 5'-diphosphate + H(+) + phosphate"}
{"X":26498,"RHEA_ID":23682,"compounds":"a ribonucleoside 5'-diphosphate + H(+) + phosphate => a ribonucleoside 5'-triphosphate + H2O"}
{"X":26499,"RHEA_ID":34329,"compounds":"1,4-benzoquinone + H2O + NADP(+) + nitrite => 4-nitrophenol + H(+) + NADPH + O2"}
{"X":26500,"RHEA_ID":23685,"DIRECTION":"LR","MASTER_ID":23684,"metacyc":"1.14.13.37-RXN","compounds":"(S)-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] => allocryptopine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":26501,"RHEA_ID":23686,"compounds":"allocryptopine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":26502,"RHEA_ID":34332,"DIRECTION":"LR","MASTER_ID":34331,"metacyc":"RXNDQC-2","compounds":"H(+) + indole-3-pyruvate + NADPH + O2 => (indol-3-yl)acetate + CO2 + H2O + NADP(+)"}
{"X":26503,"RHEA_ID":34333,"compounds":"(indol-3-yl)acetate + CO2 + H2O + NADP(+) => H(+) + indole-3-pyruvate + NADPH + O2"}
{"X":26504,"RHEA_ID":23689,"DIRECTION":"LR","MASTER_ID":23688,"ecocyc":"ADENINE-DEAMINASE-RXN","metacyc":"ADENINE-DEAMINASE-RXN","compounds":"adenine + H(+) + H2O => hypoxanthine + NH4(+)"}
{"X":26505,"RHEA_ID":23690,"compounds":"hypoxanthine + NH4(+) => adenine + H(+) + H2O"}
{"X":26506,"RHEA_ID":34336,"DIRECTION":"LR","MASTER_ID":34335,"metacyc":"RXN-7875","compounds":"cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 22R-hydroxycholesterol + H2O + 2 oxidized [adrenodoxin]"}
{"X":26507,"RHEA_ID":34337,"compounds":"22R-hydroxycholesterol + H2O + 2 oxidized [adrenodoxin] => cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}
{"X":26508,"RHEA_ID":23693,"compounds":"(R)-malate => H2O + maleate"}
{"X":26509,"RHEA_ID":23694,"compounds":"H2O + maleate => (R)-malate"}
{"X":26510,"RHEA_ID":34340,"DIRECTION":"LR","MASTER_ID":34339,"metacyc":"RXN66-338","compounds":"22R-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (20R,22R)-20,22-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin]"}
{"X":26511,"RHEA_ID":34341,"compounds":"(20R,22R)-20,22-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin] => 22R-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}
{"X":26512,"RHEA_ID":23697,"DIRECTION":"LR","MASTER_ID":23696,"metacyc":"MYO-INOSITOL-OXYGENASE-RXN","compounds":"myo-inositol + O2 => D-glucuronate + H(+) + H2O"}
{"X":26513,"RHEA_ID":23698,"compounds":"D-glucuronate + H(+) + H2O => myo-inositol + O2"}
{"X":26514,"RHEA_ID":34344,"DIRECTION":"LR","MASTER_ID":34343,"metacyc":"RXN66-339","compounds":"(20R,22R)-20,22-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 4-methylpentanal + 2 H2O + 2 oxidized [adrenodoxin] + pregnenolone"}
{"X":26515,"RHEA_ID":23700,"DIRECTION":"UN","MASTER_ID":23700,"ec":"3.5.4.9","compounds":"5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)"}
{"X":26516,"RHEA_ID":23701,"DIRECTION":"LR","MASTER_ID":23700,"reactome":"R-HSA-6801462.1","compounds":"5,10-methenyltetrahydrofolate + H2O => (6S)-10-formyltetrahydrofolate + H(+)"}
{"X":26517,"RHEA_ID":23702,"compounds":"(6S)-10-formyltetrahydrofolate + H(+) => 5,10-methenyltetrahydrofolate + H2O"}
{"X":26518,"RHEA_ID":34348,"compounds":"geraniol + NAD(+) => geranial + H(+) + NADH"}
{"X":26519,"RHEA_ID":34349,"compounds":"geranial + H(+) + NADH => geraniol + NAD(+)"}
{"X":26520,"RHEA_ID":23705,"DIRECTION":"LR","MASTER_ID":23704,"ecocyc":"GTP-CYCLOHYDRO-II-RXN","metacyc":"GTP-CYCLOHYDRO-II-RXN","compounds":"GTP + 3 H2O => 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + diphosphate + formate + 2 H(+)"}
{"X":26521,"RHEA_ID":23706,"compounds":"2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + diphosphate + formate + 2 H(+) => GTP + 3 H2O"}
{"X":26522,"RHEA_ID":34352,"compounds":"geranial + H2O + NAD(+) => geranate + 2 H(+) + NADH"}
{"X":26523,"RHEA_ID":34353,"compounds":"geranate + 2 H(+) + NADH => geranial + H2O + NAD(+)"}
{"X":26524,"RHEA_ID":23709,"DIRECTION":"LR","MASTER_ID":23708,"metacyc":"2.4.1.129-RXN","compounds":"[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-diphospho-di-trans,octa-cis-undecaprenol + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol => [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-diphospho-di-trans-octa-cis-undecaprenol + di-trans,octa-cis-undecaprenyl diphosphate + H(+)"}
{"X":26525,"RHEA_ID":23710,"compounds":"[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-diphospho-di-trans-octa-cis-undecaprenol + di-trans,octa-cis-undecaprenyl diphosphate + H(+) => [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-diphospho-di-trans,octa-cis-undecaprenol + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol"}
{"X":26526,"RHEA_ID":34361,"compounds":"a 2-acylglycerol + a carboxylate + H(+) => a 1,2-diacylglycerol + H2O"}
{"X":26527,"RHEA_ID":23713,"compounds":"NADP(+) + pregnan-21-ol => H(+) + NADPH + pregnan-21-al"}
{"X":26528,"RHEA_ID":23714,"compounds":"H(+) + NADPH + pregnan-21-al => NADP(+) + pregnan-21-ol"}
{"X":26529,"RHEA_ID":34364,"compounds":"H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UTP => diphosphate + UDP-N-acetyl-alpha-D-galactosamine"}
{"X":26530,"RHEA_ID":34365,"compounds":"diphosphate + UDP-N-acetyl-alpha-D-galactosamine => H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UTP"}
{"X":26531,"RHEA_ID":23717,"DIRECTION":"LR","MASTER_ID":23716,"macie":"M0341","compounds":"(3Z)-dodecenoyl-CoA => (2E)-dodecenoyl-CoA"}
{"X":26532,"RHEA_ID":23718,"compounds":"(2E)-dodecenoyl-CoA => (3Z)-dodecenoyl-CoA"}
{"X":26533,"RHEA_ID":34368,"DIRECTION":"LR","MASTER_ID":34367,"metacyc":"R311-RXN","compounds":"acrylamide + H2O => acrylate + NH4(+)"}
{"X":26534,"RHEA_ID":23720,"DIRECTION":"UN","MASTER_ID":23720,"ec":"6.4.1.3","compounds":"ATP + hydrogencarbonate + propanoyl-CoA = (S)-methylmalonyl-CoA + ADP + H(+) + phosphate"}
{"X":26535,"RHEA_ID":23721,"DIRECTION":"LR","MASTER_ID":23720,"ecocyc":"PROPIONYL-COA-CARBOXY-RXN","macie":"M0201","compounds":"ATP + hydrogencarbonate + propanoyl-CoA => (S)-methylmalonyl-CoA + ADP + H(+) + phosphate"}
{"X":26536,"RHEA_ID":23722,"compounds":"(S)-methylmalonyl-CoA + ADP + H(+) + phosphate => ATP + hydrogencarbonate + propanoyl-CoA"}
{"X":26537,"RHEA_ID":34372,"DIRECTION":"LR","MASTER_ID":34371,"metacyc":"RXNN-404","compounds":"H2O + indole-3-acetamide => (indol-3-yl)acetate + NH4(+)"}
{"X":26538,"RHEA_ID":34373,"compounds":"(indol-3-yl)acetate + NH4(+) => H2O + indole-3-acetamide"}
{"X":26539,"RHEA_ID":23725,"DIRECTION":"LR","MASTER_ID":23724,"metacyc":"PYRIDOXAL-OXIDASE-RXN","reactome":"R-HSA-3204311.1","compounds":"H2O + O2 + pyridoxal => 4-pyridoxate + H(+) + H2O2"}
{"X":26540,"RHEA_ID":23726,"compounds":"4-pyridoxate + H(+) + H2O2 => H2O + O2 + pyridoxal"}
{"X":26541,"RHEA_ID":34376,"DIRECTION":"LR","MASTER_ID":34375,"metacyc":"GUANIDINOBUTANAMIDE-NH3-RXN","compounds":"4-guanidinobutanamide + H2O => 4-guanidinobutanoate + NH4(+)"}
{"X":26542,"RHEA_ID":34377,"compounds":"4-guanidinobutanoate + NH4(+) => 4-guanidinobutanamide + H2O"}
{"X":26543,"RHEA_ID":23729,"DIRECTION":"LR","MASTER_ID":23728,"metacyc":"PROSTAGLANDIN-ENDOPEROXIDE-SYNTHASE-RXN","compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 => A + H2O + prostaglandin H2"}
{"X":26544,"RHEA_ID":23730,"compounds":"A + H2O + prostaglandin H2 => (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2"}
{"X":26545,"RHEA_ID":34380,"compounds":"alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 UDP-alpha-D-galactofuranose => beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 H(+) + 2 UDP"}
{"X":26546,"RHEA_ID":34381,"compounds":"beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 H(+) + 2 UDP => alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 UDP-alpha-D-galactofuranose"}
{"X":26547,"RHEA_ID":23733,"DIRECTION":"LR","MASTER_ID":23732,"metacyc":"DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN","reactome":"R-HSA-191414.1","compounds":"(R)-5-diphosphomevalonate + ATP => ADP + CO2 + isopentenyl diphosphate + phosphate"}
{"X":26548,"RHEA_ID":23734,"compounds":"ADP + CO2 + isopentenyl diphosphate + phosphate => (R)-5-diphosphomevalonate + ATP"}
{"X":26549,"RHEA_ID":34384,"DIRECTION":"LR","MASTER_ID":34383,"metacyc":"RXN-11072","compounds":"alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + UDP-alpha-D-galactofuranose => beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + H(+) + UDP"}
{"X":26550,"RHEA_ID":34385,"compounds":"beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + H(+) + UDP => alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + UDP-alpha-D-galactofuranose"}
{"X":26551,"RHEA_ID":23737,"DIRECTION":"LR","MASTER_ID":23736,"metacyc":"3.5.2.17-RXN","compounds":"5-hydroxyisourate + H2O => 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)"}
{"X":26552,"RHEA_ID":23738,"compounds":"5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+) => 5-hydroxyisourate + H2O"}
{"X":26553,"RHEA_ID":34388,"DIRECTION":"LR","MASTER_ID":34387,"metacyc":"RXN-11075","compounds":"beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + UDP-alpha-D-galactofuranose => beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + H(+) + UDP"}
{"X":26554,"RHEA_ID":34389,"compounds":"beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + H(+) + UDP => beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + UDP-alpha-D-galactofuranose"}
{"X":26555,"RHEA_ID":23741,"compounds":"4-hydroxyphenylacetonitrile + H(+) + NADPH + O2 => 4-hydroxymandelonitrile + H2O + NADP(+)"}
{"X":26556,"RHEA_ID":23742,"compounds":"4-hydroxymandelonitrile + H2O + NADP(+) => 4-hydroxyphenylacetonitrile + H(+) + NADPH + O2"}
{"X":26557,"RHEA_ID":34392,"DIRECTION":"LR","MASTER_ID":34391,"metacyc":"RXN-11077","compounds":"beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 UDP-alpha-D-galactofuranose => [beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->6)]14-beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 H(+) + 28 UDP"}
{"X":26558,"RHEA_ID":23744,"DIRECTION":"UN","MASTER_ID":23744,"ec":"2.6.1.9","compounds":"2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate"}
{"X":26559,"RHEA_ID":23745,"compounds":"2-oxoglutarate + L-histidinol phosphate => 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate"}
{"X":26560,"RHEA_ID":23746,"compounds":"3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate => 2-oxoglutarate + L-histidinol phosphate"}
{"X":26561,"RHEA_ID":34396,"DIRECTION":"LR","MASTER_ID":34395,"metacyc":"RXN-13484","compounds":"L-phenylalanine => L-beta-phenylalanine"}
{"X":26562,"RHEA_ID":34397,"compounds":"L-beta-phenylalanine => L-phenylalanine"}
{"X":26563,"RHEA_ID":23749,"DIRECTION":"LR","MASTER_ID":23748,"metacyc":"RXN-15539","compounds":"ATP + GTP => diphosphate + pppGp(2'-5')A"}
{"X":26564,"RHEA_ID":23750,"compounds":"diphosphate + pppGp(2'-5')A => ATP + GTP"}
{"X":26565,"RHEA_ID":23751,"compounds":"ATP + GTP <=> diphosphate + pppGp(2'-5')A"}
{"X":26566,"RHEA_ID":34401,"compounds":"9-cis-10'-apo-beta-carotenal + beta-ionone => 9-cis-beta-carotene + O2"}
{"X":26567,"RHEA_ID":23753,"compounds":"all-trans-undecaprenol + ATP => ADP + all-trans-undecaprenyl phosphate + H(+)"}
{"X":26568,"RHEA_ID":23754,"compounds":"ADP + all-trans-undecaprenyl phosphate + H(+) => all-trans-undecaprenol + ATP"}
{"X":26569,"RHEA_ID":34404,"DIRECTION":"LR","MASTER_ID":34403,"metacyc":"RXN-13643","compounds":"9-cis-10'-apo-beta-carotenal + 2 O2 => (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal + carlactone"}
{"X":26570,"RHEA_ID":34405,"compounds":"(2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal + carlactone => 9-cis-10'-apo-beta-carotenal + 2 O2"}
{"X":26571,"RHEA_ID":23757,"compounds":"D-arabinono-1,4-lactone + O2 => dehydro-D-arabinono-1,4-lactone + H(+) + H2O2"}
{"X":26572,"RHEA_ID":23758,"compounds":"dehydro-D-arabinono-1,4-lactone + H(+) + H2O2 => D-arabinono-1,4-lactone + O2"}
{"X":26573,"RHEA_ID":34408,"DIRECTION":"LR","MASTER_ID":34407,"metacyc":"RXN-13648","compounds":"3 ATP => 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 diphosphate"}
{"X":26574,"RHEA_ID":34409,"compounds":"5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 diphosphate => 3 ATP"}
{"X":26575,"RHEA_ID":23761,"DIRECTION":"LR","MASTER_ID":23760,"metacyc":"COENZYME-F420-HYDROGENASE-RXN","compounds":"H(+) + H2 + oxidized coenzyme F420-(gamma-Glu)(n) => reduced coenzyme F420-(gamma-Glu)(n)"}
{"X":26576,"RHEA_ID":23762,"compounds":"reduced coenzyme F420-(gamma-Glu)(n) => H(+) + H2 + oxidized coenzyme F420-(gamma-Glu)(n)"}
{"X":26577,"RHEA_ID":34412,"DIRECTION":"LR","MASTER_ID":34411,"metacyc":"RXN-7855","compounds":"cannabigerolate + O2 => cannabidiolate + H2O2"}
{"X":26578,"RHEA_ID":23764,"DIRECTION":"UN","MASTER_ID":23764,"ec":"2.7.1.80","compounds":"diphosphate + L-serine = H(+) + O-phospho-L-serine + phosphate"}
{"X":26579,"RHEA_ID":23765,"DIRECTION":"LR","MASTER_ID":23764,"metacyc":"2.7.1.80-RXN","compounds":"diphosphate + L-serine => H(+) + O-phospho-L-serine + phosphate"}
{"X":26580,"RHEA_ID":23766,"compounds":"H(+) + O-phospho-L-serine + phosphate => diphosphate + L-serine"}
{"X":26581,"RHEA_ID":34416,"DIRECTION":"LR","MASTER_ID":34415,"metacyc":"R543-RXN","compounds":"(1R,4R)-bornane-2,5-dione + FMNH2 + O2 => (1R,4R)-5-oxo-1,2-campholide + FMN + H(+) + H2O"}
{"X":26582,"RHEA_ID":23768,"DIRECTION":"UN","MASTER_ID":23768,"ec":"2.3.1.24","compounds":"an acyl-CoA + sphing-4-enine = an N-acylsphing-4-enine + CoA + H(+)"}
{"X":26583,"RHEA_ID":23769,"compounds":"an acyl-CoA + sphing-4-enine => an N-acylsphing-4-enine + CoA + H(+)"}
{"X":26584,"RHEA_ID":23770,"compounds":"an N-acylsphing-4-enine + CoA + H(+) => an acyl-CoA + sphing-4-enine"}
{"X":26585,"RHEA_ID":34420,"compounds":"(+)-lariciresinol + NADP(+) => (+)-pinoresinol + H(+) + NADPH"}
{"X":26586,"RHEA_ID":23772,"DIRECTION":"UN","MASTER_ID":23772,"ec":"1.3.1.58","compounds":"(2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+) = 2,3-dihydroxy-p-cumate + H(+) + NADH"}
{"X":26587,"RHEA_ID":23773,"compounds":"(2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+) => 2,3-dihydroxy-p-cumate + H(+) + NADH"}
{"X":26588,"RHEA_ID":23774,"compounds":"2,3-dihydroxy-p-cumate + H(+) + NADH => (2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+)"}
{"X":26589,"RHEA_ID":34424,"compounds":"(-)-secoisolariciresinol + NADP(+) => (+)-lariciresinol + H(+) + NADPH"}
{"X":26590,"RHEA_ID":34425,"DIRECTION":"RL","MASTER_ID":34423,"metacyc":"RXN-8679","compounds":"(+)-lariciresinol + H(+) + NADPH => (-)-secoisolariciresinol + NADP(+)"}
{"X":26591,"RHEA_ID":23777,"DIRECTION":"LR","MASTER_ID":23776,"ecocyc":"ASPARTATEKIN-RXN","compounds":"ATP + L-aspartate => 4-phospho-L-aspartate + ADP"}
{"X":26592,"RHEA_ID":23778,"compounds":"4-phospho-L-aspartate + ADP => ATP + L-aspartate"}
{"X":26593,"RHEA_ID":34428,"compounds":"(-)-lariciresinol + NADP(+) => (-)-pinoresinol + H(+) + NADPH"}
{"X":26594,"RHEA_ID":34429,"DIRECTION":"RL","MASTER_ID":34427,"metacyc":"RXN-8683","compounds":"(-)-pinoresinol + H(+) + NADPH => (-)-lariciresinol + NADP(+)"}
{"X":26595,"RHEA_ID":23781,"DIRECTION":"LR","MASTER_ID":23780,"ecocyc":"2-METHYLCITRATE-SYNTHASE-RXN","compounds":"H2O + oxaloacetate + propanoyl-CoA => (2S,3S)-2-methylcitrate + CoA + H(+)"}
{"X":26596,"RHEA_ID":23782,"compounds":"(2S,3S)-2-methylcitrate + CoA + H(+) => H2O + oxaloacetate + propanoyl-CoA"}
{"X":26597,"RHEA_ID":34432,"compounds":"(+)-secoisolariciresinol + NADP(+) => (-)-lariciresinol + H(+) + NADPH"}
{"X":26598,"RHEA_ID":34433,"DIRECTION":"RL","MASTER_ID":34431,"metacyc":"RXN-8684","compounds":"(-)-lariciresinol + H(+) + NADPH => (+)-secoisolariciresinol + NADP(+)"}
{"X":26599,"RHEA_ID":23785,"DIRECTION":"LR","MASTER_ID":23784,"metacyc":"RXN-14903","compounds":"a quinone + L-proline => (S)-1-pyrroline-5-carboxylate + a quinol + H(+)"}
{"X":26600,"RHEA_ID":23786,"compounds":"(S)-1-pyrroline-5-carboxylate + a quinol + H(+) => a quinone + L-proline"}
{"X":26601,"RHEA_ID":34436,"DIRECTION":"LR","MASTER_ID":34435,"metacyc":"RXN-11386","compounds":"4-(3-methylbut-2-enyl)-L-tryptophan + S-adenosyl-L-methionine => 4-(3-methylbut-2-enyl)-L-abrine + H(+) + S-adenosyl-L-homocysteine"}
{"X":26602,"RHEA_ID":23788,"DIRECTION":"UN","MASTER_ID":23788,"ec":"6.2.1.22","compounds":"acetate + ATP + holo-[citrate lyase ACP] = acetyl-[citrate lyase ACP] + AMP + diphosphate"}
{"X":26603,"RHEA_ID":23789,"DIRECTION":"LR","MASTER_ID":23788,"ecocyc":"CITC-RXN","metacyc":"CITC-RXN","compounds":"acetate + ATP + holo-[citrate lyase ACP] => acetyl-[citrate lyase ACP] + AMP + diphosphate"}
{"X":26604,"RHEA_ID":23790,"compounds":"acetyl-[citrate lyase ACP] + AMP + diphosphate => acetate + ATP + holo-[citrate lyase ACP]"}
{"X":26605,"RHEA_ID":34440,"compounds":"2,3-didehydroadipyl-CoA + acetyl-CoA => 3-oxo-5,6-didehydrosuberyl-CoA + CoA"}
{"X":26606,"RHEA_ID":23796,"DIRECTION":"UN","MASTER_ID":23796,"ec":"3.1.1.80","compounds":"17-O-acetylnorajmaline + H2O = acetate + H(+) + norajmaline"}
{"X":26607,"RHEA_ID":23797,"DIRECTION":"LR","MASTER_ID":23796,"metacyc":"RXN-8653","compounds":"17-O-acetylnorajmaline + H2O => acetate + H(+) + norajmaline"}
{"X":26608,"RHEA_ID":23797,"DIRECTION":"LR","MASTER_ID":23796,"metacyc":"RXN-8220","compounds":"17-O-acetylnorajmaline + H2O => acetate + H(+) + norajmaline"}
{"X":26609,"RHEA_ID":23798,"compounds":"acetate + H(+) + norajmaline => 17-O-acetylnorajmaline + H2O"}
{"X":26610,"RHEA_ID":34445,"compounds":"CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + H(+) => acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose"}
{"X":26611,"RHEA_ID":23800,"DIRECTION":"UN","MASTER_ID":23800,"ec":"4.4.1.11","compounds":"H2O + L-methionine = 2-oxobutanoate + methanethiol + NH4(+)"}
{"X":26612,"RHEA_ID":23801,"DIRECTION":"LR","MASTER_ID":23800,"metacyc":"METHIONINE-GAMMA-LYASE-RXN","compounds":"H2O + L-methionine => 2-oxobutanoate + methanethiol + NH4(+)"}
{"X":26613,"RHEA_ID":23802,"compounds":"2-oxobutanoate + methanethiol + NH4(+) => H2O + L-methionine"}
{"X":26614,"RHEA_ID":44372,"compounds":"Cr(6+) + 2 NADH + O2 = Cr(3+) + 2 H(+) + 2 NAD(+) + superoxide"}
{"X":26615,"RHEA_ID":23804,"DIRECTION":"UN","MASTER_ID":23804,"ec":"5.4.2.3","compounds":"N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate"}
{"X":26616,"RHEA_ID":23805,"compounds":"N-acetyl-alpha-D-glucosamine 1-phosphate => N-acetyl-D-glucosamine 6-phosphate"}
{"X":26617,"RHEA_ID":23806,"compounds":"N-acetyl-D-glucosamine 6-phosphate => N-acetyl-alpha-D-glucosamine 1-phosphate"}
{"X":26618,"RHEA_ID":44376,"compounds":"a 1-acyl-sn-glycero-3-phosphocholine(in) = a 1-acyl-sn-glycero-3-phosphocholine(out)"}
{"X":26619,"RHEA_ID":23808,"DIRECTION":"UN","MASTER_ID":23808,"ec":"2.1.1.117","compounds":"(S)-scoulerine + S-adenosyl-L-methionine = (S)-tetrahydrocolumbamine + H(+) + S-adenosyl-L-homocysteine"}
{"X":26620,"RHEA_ID":23809,"DIRECTION":"LR","MASTER_ID":23808,"metacyc":"2.1.1.117-RXN","compounds":"(S)-scoulerine + S-adenosyl-L-methionine => (S)-tetrahydrocolumbamine + H(+) + S-adenosyl-L-homocysteine"}
{"X":26621,"RHEA_ID":23810,"compounds":"(S)-tetrahydrocolumbamine + H(+) + S-adenosyl-L-homocysteine => (S)-scoulerine + S-adenosyl-L-methionine"}
{"X":26622,"RHEA_ID":44380,"DIRECTION":"UN","MASTER_ID":44380,"ec":"2.1.1.64","compounds":"a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + H(+) + S-adenosyl-L-homocysteine"}
{"X":26623,"RHEA_ID":23812,"DIRECTION":"UN","MASTER_ID":23812,"ec":"1.1.1.208","compounds":"(+)-neomenthol + NADP(+) = (1R,4S)-menthone + H(+) + NADPH"}
{"X":26624,"RHEA_ID":23813,"compounds":"(+)-neomenthol + NADP(+) => (1R,4S)-menthone + H(+) + NADPH"}
{"X":26625,"RHEA_ID":23814,"DIRECTION":"RL","MASTER_ID":23812,"metacyc":"%2b-NEOMENTHOL-DEHYDROGENASE-RXN","compounds":"(1R,4S)-menthone + H(+) + NADPH => (+)-neomenthol + NADP(+)"}
{"X":26626,"RHEA_ID":44384,"compounds":"1-heptadecanoyl-sn-glycero-3-phosphate + dodecanoyl-CoA = 1-heptadecanoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":26627,"RHEA_ID":23816,"compounds":"2-oxoglutarate + putrescine = 4-aminobutanal + L-glutamate"}
{"X":26628,"RHEA_ID":23817,"DIRECTION":"LR","MASTER_ID":23816,"ecocyc":"PUTTRANSAM-RXN","metacyc":"PUTTRANSAM-RXN","compounds":"2-oxoglutarate + putrescine => 4-aminobutanal + L-glutamate"}
{"X":26629,"RHEA_ID":23818,"compounds":"4-aminobutanal + L-glutamate => 2-oxoglutarate + putrescine"}
{"X":26630,"RHEA_ID":34464,"DIRECTION":"LR","MASTER_ID":34463,"metacyc":"RXN-13770","compounds":"8-hydroxycopalyl diphosphate => cis-abienol + diphosphate"}
{"X":26631,"RHEA_ID":23820,"DIRECTION":"UN","MASTER_ID":23820,"ec":"4.2.1.47","compounds":"GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O"}
{"X":26632,"RHEA_ID":23821,"DIRECTION":"LR","MASTER_ID":23820,"ecocyc":"GDPMANDEHYDRA-RXN","metacyc":"GDPMANDEHYDRA-RXN","reactome":"R-HSA-6787632.1","compounds":"GDP-alpha-D-mannose => GDP-4-dehydro-alpha-D-rhamnose + H2O"}
{"X":26633,"RHEA_ID":23822,"compounds":"GDP-4-dehydro-alpha-D-rhamnose + H2O => GDP-alpha-D-mannose"}
{"X":26634,"RHEA_ID":44392,"compounds":"1-heptadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-heptadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":26635,"RHEA_ID":23824,"DIRECTION":"UN","MASTER_ID":23824,"ec":"1.3.1.28","compounds":"(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD(+) = 2,3-dihydroxybenzoate + H(+) + NADH"}
{"X":26636,"RHEA_ID":23825,"DIRECTION":"LR","MASTER_ID":23824,"ecocyc":"DHBDEHYD-RXN","metacyc":"DHBDEHYD-RXN","compounds":"(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD(+) => 2,3-dihydroxybenzoate + H(+) + NADH"}
{"X":26637,"RHEA_ID":23826,"compounds":"2,3-dihydroxybenzoate + H(+) + NADH => (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD(+)"}
{"X":26638,"RHEA_ID":44396,"compounds":"1-heptadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-heptadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":26639,"RHEA_ID":23828,"DIRECTION":"UN","MASTER_ID":23828,"ec":"1.1.1.274","compounds":"2-dehydro-D-gluconate + NADP(+) = 2,5-didehydro-D-gluconate + H(+) + NADPH"}
{"X":26640,"RHEA_ID":23829,"compounds":"2-dehydro-D-gluconate + NADP(+) => 2,5-didehydro-D-gluconate + H(+) + NADPH"}
{"X":26641,"RHEA_ID":23830,"compounds":"2,5-didehydro-D-gluconate + H(+) + NADPH => 2-dehydro-D-gluconate + NADP(+)"}
{"X":26642,"RHEA_ID":44400,"DIRECTION":"UN","MASTER_ID":44400,"ec":"2.1.1.64","compounds":"3-demethylubiquinol-6 + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + ubiquinol-6"}
{"X":26643,"RHEA_ID":23832,"DIRECTION":"UN","MASTER_ID":23832,"ec":"2.7.1.60","compounds":"an N-acyl-D-mannosamine + ATP = ADP + an N-acyl-D-mannosamine 6-phosphate + H(+)"}
{"X":26644,"RHEA_ID":23833,"compounds":"an N-acyl-D-mannosamine + ATP => ADP + an N-acyl-D-mannosamine 6-phosphate + H(+)"}
{"X":26645,"RHEA_ID":23834,"compounds":"ADP + an N-acyl-D-mannosamine 6-phosphate + H(+) => an N-acyl-D-mannosamine + ATP"}
{"X":26646,"RHEA_ID":34480,"DIRECTION":"LR","MASTER_ID":34479,"metacyc":"RXNARA-8002","compounds":"(1R,2R,3R)-prephytoene diphosphate => 15-cis-phytoene + diphosphate"}
{"X":26647,"RHEA_ID":34481,"compounds":"15-cis-phytoene + diphosphate => (1R,2R,3R)-prephytoene diphosphate"}
{"X":26648,"RHEA_ID":23837,"compounds":"D-methionine + pyruvate => 4-methylsulfanyl-2-oxobutanoate + L-alanine"}
{"X":26649,"RHEA_ID":23838,"compounds":"4-methylsulfanyl-2-oxobutanoate + L-alanine => D-methionine + pyruvate"}
{"X":26650,"RHEA_ID":34484,"DIRECTION":"LR","MASTER_ID":34483,"metacyc":"RXN-8458","compounds":"4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA => 4-hydroxybenzalacetone + 2 CO2 + 2 CoA"}
{"X":26651,"RHEA_ID":34485,"compounds":"4-hydroxybenzalacetone + 2 CO2 + 2 CoA => 4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA"}
{"X":26652,"RHEA_ID":23841,"DIRECTION":"LR","MASTER_ID":23840,"ecocyc":"1.13.11.16-RXN","metacyc":"1.13.11.16-RXN","compounds":"3-(2,3-dihydroxyphenyl)propanoate + O2 => (2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H(+)"}
{"X":26653,"RHEA_ID":23842,"compounds":"(2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H(+) => 3-(2,3-dihydroxyphenyl)propanoate + O2"}
{"X":26654,"RHEA_ID":34488,"DIRECTION":"LR","MASTER_ID":34487,"metacyc":"RXN-11070","compounds":"dTDP-beta-L-rhamnose + N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol => alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + dTDP + H(+)"}
{"X":26655,"RHEA_ID":34489,"compounds":"alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + dTDP + H(+) => dTDP-beta-L-rhamnose + N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol"}
{"X":26656,"RHEA_ID":23845,"DIRECTION":"LR","MASTER_ID":23844,"reactome":"R-HSA-8959719.2","compounds":"ATP + sedoheptulose => ADP + D-sedoheptulose 7-phosphate + H(+)"}
{"X":26657,"RHEA_ID":23846,"compounds":"ADP + D-sedoheptulose 7-phosphate + H(+) => ATP + sedoheptulose"}
{"X":26658,"RHEA_ID":34492,"DIRECTION":"LR","MASTER_ID":34491,"metacyc":"RXN-13574","compounds":"H2O + UDP-N,N'-diacetylbacillosamine => 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H(+) + UDP"}
{"X":26659,"RHEA_ID":23852,"DIRECTION":"UN","MASTER_ID":23852,"ec":"1.13.11.1","compounds":"catechol + O2 = cis,cis-muconate + 2 H(+)"}
{"X":26660,"RHEA_ID":23853,"DIRECTION":"LR","MASTER_ID":23852,"metacyc":"CATECHOL-12-DIOXYGENASE-RXN","compounds":"catechol + O2 => cis,cis-muconate + 2 H(+)"}
{"X":26661,"RHEA_ID":23854,"compounds":"cis,cis-muconate + 2 H(+) => catechol + O2"}
{"X":26662,"RHEA_ID":34496,"DIRECTION":"LR","MASTER_ID":34495,"metacyc":"RXN-1321","compounds":"(9Z,12Z,15Z)-octadecatrienoate + O2 => (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate"}
{"X":26663,"RHEA_ID":34497,"compounds":"(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2"}
{"X":26664,"RHEA_ID":23857,"compounds":"H(+) + Hg + NADP(+) => Hg(2+) + NADPH"}
{"X":26665,"RHEA_ID":23858,"DIRECTION":"RL","MASTER_ID":23856,"metacyc":"MERCURY-II-REDUCTASE-RXN","compounds":"Hg(2+) + NADPH => H(+) + Hg + NADP(+)"}
{"X":26666,"RHEA_ID":34501,"compounds":"H2O + oxidized 2[4Fe-4S]-[ferredoxin] + pentalenate => 1-deoxypentalenate + 2 H(+) + O2 + reduced 2[4Fe-4S]-[ferredoxin]"}
{"X":26667,"RHEA_ID":23861,"DIRECTION":"LR","MASTER_ID":23860,"metacyc":"2.3.1.175-RXN","compounds":"acetyl-CoA + deacetylcephalosporin C => cephalosporin C + CoA"}
{"X":26668,"RHEA_ID":23862,"compounds":"cephalosporin C + CoA => acetyl-CoA + deacetylcephalosporin C"}
{"X":26669,"RHEA_ID":34504,"DIRECTION":"LR","MASTER_ID":34503,"metacyc":"RXN-13764","compounds":"(2E,6E)-farnesyl diphosphate + H2O => (+)-epi-alpha-bisabolol + diphosphate"}
{"X":26670,"RHEA_ID":34505,"compounds":"(+)-epi-alpha-bisabolol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}
{"X":26671,"RHEA_ID":23865,"DIRECTION":"LR","MASTER_ID":23864,"ecocyc":"RXN0-302","metacyc":"RXN0-302","compounds":"4-CDP-2-C-methyl-D-erythritol 2-phosphate => 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP"}
{"X":26672,"RHEA_ID":23866,"compounds":"2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP => 4-CDP-2-C-methyl-D-erythritol 2-phosphate"}
{"X":26673,"RHEA_ID":34508,"DIRECTION":"LR","MASTER_ID":34507,"metacyc":"RXN-12238","compounds":"2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H2O + phosphoenolpyruvate => N,N-diacetyllegionaminate + phosphate"}
{"X":26674,"RHEA_ID":34509,"compounds":"N,N-diacetyllegionaminate + phosphate => 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H2O + phosphoenolpyruvate"}
{"X":26675,"RHEA_ID":23869,"compounds":"(1-hydroxycyclohexan-1-yl)acetyl-CoA => acetyl-CoA + cyclohexanone"}
{"X":26676,"RHEA_ID":23870,"compounds":"acetyl-CoA + cyclohexanone => (1-hydroxycyclohexan-1-yl)acetyl-CoA"}
{"X":26677,"RHEA_ID":34512,"DIRECTION":"LR","MASTER_ID":34511,"metacyc":"RXN-13274","compounds":"N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UDP-N-acetyl-alpha-D-galactosamine => H(+) + N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP"}
{"X":26678,"RHEA_ID":34513,"compounds":"H(+) + N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP => N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UDP-N-acetyl-alpha-D-galactosamine"}
{"X":26679,"RHEA_ID":23873,"compounds":"(R)-propane-1,2-diol + NAD(+) => (R)-lactaldehyde + H(+) + NADH"}
{"X":26680,"RHEA_ID":23874,"DIRECTION":"RL","MASTER_ID":23872,"metacyc":"RXN-8641","compounds":"(R)-lactaldehyde + H(+) + NADH => (R)-propane-1,2-diol + NAD(+)"}
{"X":26681,"RHEA_ID":34517,"compounds":"N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UMP => tri-trans,hepta-cis-undecaprenyl phosphate + UDP-N,N'-diacetylbacillosamine"}
{"X":26682,"RHEA_ID":23877,"compounds":"protoaphin aglucone => H2O + xanthoaphin"}
{"X":26683,"RHEA_ID":23878,"compounds":"H2O + xanthoaphin => protoaphin aglucone"}
{"X":26684,"RHEA_ID":34520,"DIRECTION":"LR","MASTER_ID":34519,"metacyc":"RXN-13276","compounds":"N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + 3 UDP-N-acetyl-alpha-D-galactosamine => [alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + 3 H(+) + 3 UDP"}
{"X":26685,"RHEA_ID":23880,"DIRECTION":"UN","MASTER_ID":23880,"ec":"2.7.3.9","compounds":"L-histidyl-[protein] + phosphoenolpyruvate = N(pros)-phospho-L-histidyl-[protein] + pyruvate"}
{"X":26686,"RHEA_ID":23881,"compounds":"L-histidyl-[protein] + phosphoenolpyruvate => N(pros)-phospho-L-histidyl-[protein] + pyruvate"}
{"X":26687,"RHEA_ID":23882,"compounds":"N(pros)-phospho-L-histidyl-[protein] + pyruvate => L-histidyl-[protein] + phosphoenolpyruvate"}
{"X":26688,"RHEA_ID":34525,"compounds":"[alpha-D-GalNAc-(1->4)]2-[beta-D-Glc-(1->3)]-[alpha-D-GalNAc-(1->4)]2-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + H(+) + UDP => [alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose"}
{"X":26689,"RHEA_ID":23885,"DIRECTION":"LR","MASTER_ID":23884,"metacyc":"NICOTINAMIDE-N-METHYLTRANSFERASE-RXN","reactome":"R-HSA-5359451.1","compounds":"nicotinamide + S-adenosyl-L-methionine => 1-methylnicotinamide + S-adenosyl-L-homocysteine"}
{"X":26690,"RHEA_ID":23886,"compounds":"1-methylnicotinamide + S-adenosyl-L-homocysteine => nicotinamide + S-adenosyl-L-methionine"}
{"X":26691,"RHEA_ID":34528,"compounds":"L-phenylalanine => (S)-3-amino-3-phenylpropanoate"}
{"X":26692,"RHEA_ID":34529,"compounds":"(S)-3-amino-3-phenylpropanoate => L-phenylalanine"}
{"X":26693,"RHEA_ID":23889,"DIRECTION":"LR","MASTER_ID":23888,"metacyc":"6.3.2.30-RXN","compounds":"[L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ATP + L-arginine => [L-4-(L-arginin-2-N-yl)aspartate](n+1) + ADP + H(+) + phosphate"}
{"X":26694,"RHEA_ID":23890,"compounds":"[L-4-(L-arginin-2-N-yl)aspartate](n+1) + ADP + H(+) + phosphate => [L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ATP + L-arginine"}
{"X":26695,"RHEA_ID":34532,"DIRECTION":"LR","MASTER_ID":34531,"metacyc":"RXN-13755","compounds":"acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose => CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-glucose + H(+)"}
{"X":26696,"RHEA_ID":34533,"compounds":"CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-glucose + H(+) => acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose"}
{"X":26697,"RHEA_ID":23893,"compounds":"3-nitropropanoate + NADP(+) => 3-nitroacrylate + H(+) + NADPH"}
{"X":26698,"RHEA_ID":23894,"compounds":"3-nitroacrylate + H(+) + NADPH => 3-nitropropanoate + NADP(+)"}
{"X":26699,"RHEA_ID":34536,"compounds":"H(+) + hexadecanoyl-CoA + L-alanine => 1-deoxy-3-dehydrosphinganine + CO2 + CoA"}
{"X":26700,"RHEA_ID":34537,"compounds":"1-deoxy-3-dehydrosphinganine + CO2 + CoA => H(+) + hexadecanoyl-CoA + L-alanine"}
{"X":26701,"RHEA_ID":23897,"compounds":"5-dehydro-4-deoxy-D-glucuronate => 3-deoxy-D-glycero-2,5-hexodiulosonate"}
{"X":26702,"RHEA_ID":23898,"compounds":"3-deoxy-D-glycero-2,5-hexodiulosonate => 5-dehydro-4-deoxy-D-glucuronate"}
{"X":26703,"RHEA_ID":34540,"DIRECTION":"LR","MASTER_ID":34539,"ecocyc":"RXN0-6576","metacyc":"RXN0-6576","compounds":"S-adenosyl-L-methionine + tellurite => methanetellurite + S-adenosyl-L-homocysteine"}
{"X":26704,"RHEA_ID":23900,"DIRECTION":"UN","MASTER_ID":23900,"ec":"3.3.2.9","compounds":"cis-stilbene oxide + H2O = (1R,2R)-hydrobenzoin"}
{"X":26705,"RHEA_ID":23901,"DIRECTION":"LR","MASTER_ID":23900,"metacyc":"3.3.2.9-RXN","compounds":"cis-stilbene oxide + H2O => (1R,2R)-hydrobenzoin"}
{"X":26706,"RHEA_ID":23902,"compounds":"(1R,2R)-hydrobenzoin => cis-stilbene oxide + H2O"}
{"X":26707,"RHEA_ID":34544,"DIRECTION":"LR","MASTER_ID":34543,"metacyc":"RXN-13275","compounds":"N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine => H(+) + N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + UDP"}
{"X":26708,"RHEA_ID":34545,"compounds":"H(+) + N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + UDP => N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine"}
{"X":26709,"RHEA_ID":23905,"compounds":"an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] => 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]"}
{"X":26710,"RHEA_ID":23906,"compounds":"5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide] => an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide]"}
{"X":26711,"RHEA_ID":23908,"DIRECTION":"UN","MASTER_ID":23908,"ec":"1.16.1.8","compounds":"2 [methionine synthase]-methylcob(III)alamin + H(+) + NADP(+) + 2 S-adenosyl-L-homocysteine = 2 [methionine synthase]-cob(II)alamin + NADPH + 2 S-adenosyl-L-methionine"}
{"X":26712,"RHEA_ID":23909,"compounds":"2 [methionine synthase]-methylcob(III)alamin + H(+) + NADP(+) + 2 S-adenosyl-L-homocysteine => 2 [methionine synthase]-cob(II)alamin + NADPH + 2 S-adenosyl-L-methionine"}
{"X":26713,"RHEA_ID":23910,"DIRECTION":"RL","MASTER_ID":23908,"metacyc":"2.1.1.135-RXN","compounds":"2 [methionine synthase]-cob(II)alamin + NADPH + 2 S-adenosyl-L-methionine => 2 [methionine synthase]-methylcob(III)alamin + H(+) + NADP(+) + 2 S-adenosyl-L-homocysteine"}
{"X":26714,"RHEA_ID":34552,"DIRECTION":"LR","MASTER_ID":34551,"metacyc":"RXN-14257","compounds":"ATP + cob(II)yrinate c monoamide + H2O + L-glutamine => ADP + cob(II)yrinate a,c diamide + H(+) + L-glutamate + phosphate"}
{"X":26715,"RHEA_ID":34553,"compounds":"ADP + cob(II)yrinate a,c diamide + H(+) + L-glutamate + phosphate => ATP + cob(II)yrinate c monoamide + H2O + L-glutamine"}
{"X":26716,"RHEA_ID":23917,"DIRECTION":"LR","MASTER_ID":23916,"metacyc":"UDP-GLUCURONATE-DECARBOXYLASE-RXN","compounds":"H(+) + UDP-alpha-D-glucuronate => CO2 + UDP-alpha-D-xylose"}
{"X":26717,"RHEA_ID":23918,"compounds":"CO2 + UDP-alpha-D-xylose => H(+) + UDP-alpha-D-glucuronate"}
{"X":26718,"RHEA_ID":34555,"DIRECTION":"UN","MASTER_ID":34555,"ec":"1.1.1.375","compounds":"a (2S)-2-hydroxycarboxylate + NAD(+) = a 2-oxocarboxylate + H(+) + NADH"}
{"X":26719,"RHEA_ID":34556,"compounds":"a (2S)-2-hydroxycarboxylate + NAD(+) => a 2-oxocarboxylate + H(+) + NADH"}
{"X":26720,"RHEA_ID":23921,"DIRECTION":"LR","MASTER_ID":23920,"ecocyc":"AICARSYN-RXN","reactome":"R-HSA-73800.2","compounds":"(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate"}
{"X":26721,"RHEA_ID":23922,"compounds":"5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate => (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate"}
{"X":26722,"RHEA_ID":34559,"DIRECTION":"UN","MASTER_ID":34559,"ec":"1.1.1.340","compounds":"1-deoxy-11beta-hydroxypentalenate + NAD(+) = 1-deoxy-11-oxopentalenate + H(+) + NADH"}
{"X":26723,"RHEA_ID":23925,"DIRECTION":"LR","MASTER_ID":23924,"metacyc":"RXN-15540","compounds":"pppGp(2'-5')A => 2',3'-cGAMP + diphosphate"}
{"X":26724,"RHEA_ID":23926,"compounds":"2',3'-cGAMP + diphosphate => pppGp(2'-5')A"}
{"X":26725,"RHEA_ID":23927,"compounds":"pppGp(2'-5')A <=> 2',3'-cGAMP + diphosphate"}
{"X":26726,"RHEA_ID":23928,"DIRECTION":"UN","MASTER_ID":23928,"ec":"3.5.1.48","compounds":"H2O + N(8)-acetylspermidine = acetate + spermidine"}
{"X":26727,"RHEA_ID":23929,"compounds":"H2O + N(8)-acetylspermidine => acetate + spermidine"}
{"X":26728,"RHEA_ID":23930,"compounds":"acetate + spermidine => H2O + N(8)-acetylspermidine"}
{"X":26729,"RHEA_ID":44492,"DIRECTION":"UN","MASTER_ID":44492,"ec":"2.1.1.114","compounds":"3,4-dihydroxy-5-all-trans-decaprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-all-trans-decaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine"}
{"X":26730,"RHEA_ID":34567,"DIRECTION":"UN","MASTER_ID":34567,"ec":"1.1.1.342","compounds":"CDP-alpha-D-paratose + NADP(+) = CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH"}
{"X":26731,"RHEA_ID":23933,"compounds":"an N-acyl-D-glucosamine 6-phosphate => an N-acyl-D-mannosamine 6-phosphate"}
{"X":26732,"RHEA_ID":23934,"compounds":"an N-acyl-D-mannosamine 6-phosphate => an N-acyl-D-glucosamine 6-phosphate"}
{"X":26733,"RHEA_ID":34571,"DIRECTION":"UN","MASTER_ID":34571,"ec":"1.3.1.97","compounds":"C30 botryococcene + diphosphate + NADP(+) = H(+) + NADPH + presqualene diphosphate"}
{"X":26734,"RHEA_ID":23937,"compounds":"D-gluconate + NADP(+) => 5-dehydro-D-gluconate + H(+) + NADPH"}
{"X":26735,"RHEA_ID":23938,"DIRECTION":"RL","MASTER_ID":23936,"ecocyc":"GLUCONATE-5-DEHYDROGENASE-RXN","metacyc":"GLUCONATE-5-DEHYDROGENASE-RXN","compounds":"5-dehydro-D-gluconate + H(+) + NADPH => D-gluconate + NADP(+)"}
{"X":26736,"RHEA_ID":44500,"compounds":"1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoserine + H(+)"}
{"X":26737,"RHEA_ID":23940,"DIRECTION":"UN","MASTER_ID":23940,"ec":"1.1.1.69","compounds":"D-gluconate + NAD(+) = 5-dehydro-D-gluconate + H(+) + NADH"}
{"X":26738,"RHEA_ID":23941,"compounds":"D-gluconate + NAD(+) => 5-dehydro-D-gluconate + H(+) + NADH"}
{"X":26739,"RHEA_ID":23942,"DIRECTION":"RL","MASTER_ID":23940,"ecocyc":"GLUCONATE-5-DEHYDROGENASE-RXN","metacyc":"GLUCONATE-5-DEHYDROGENASE-RXN","compounds":"5-dehydro-D-gluconate + H(+) + NADH => D-gluconate + NAD(+)"}
{"X":26740,"RHEA_ID":44504,"DIRECTION":"UN","MASTER_ID":44504,"ec":"2.5.1.39","compounds":"4-hydroxybenzoate + an all-trans-polyprenyl diphosphate = a 4-hydroxy-3-all-trans-polyprenylbenzoate + diphosphate"}
{"X":26741,"RHEA_ID":23944,"DIRECTION":"UN","MASTER_ID":23944,"ec":"2.4.1.111","compounds":"(E)-coniferol + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-trans-coniferol + H(+) + UDP"}
{"X":26742,"RHEA_ID":23945,"DIRECTION":"LR","MASTER_ID":23944,"metacyc":"2.4.1.111-RXN","compounds":"(E)-coniferol + UDP-alpha-D-glucose => 4-O-(beta-D-glucosyl)-trans-coniferol + H(+) + UDP"}
{"X":26743,"RHEA_ID":23946,"compounds":"4-O-(beta-D-glucosyl)-trans-coniferol + H(+) + UDP => (E)-coniferol + UDP-alpha-D-glucose"}
{"X":26744,"RHEA_ID":44508,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine"}
{"X":26745,"RHEA_ID":34583,"compounds":"2-oxoglutarate + O2 + pentalenolactone D = CO2 + H2O + pentalenolactone E + succinate"}
{"X":26746,"RHEA_ID":23949,"compounds":"4-hydroxybutanoate + NAD(+) => H(+) + NADH + succinate semialdehyde"}
{"X":26747,"RHEA_ID":23950,"DIRECTION":"RL","MASTER_ID":23948,"ecocyc":"4-HYDROXYBUTYRATE-DEHYDROGENASE-RXN","metacyc":"4-HYDROXYBUTYRATE-DEHYDROGENASE-RXN","compounds":"H(+) + NADH + succinate semialdehyde => 4-hydroxybutanoate + NAD(+)"}
{"X":26748,"RHEA_ID":44512,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphocholine"}
{"X":26749,"RHEA_ID":34587,"compounds":"2-oxoglutarate + O2 + pentalenolactone E = CO2 + pentalenolactone F + succinate"}
{"X":26750,"RHEA_ID":23953,"DIRECTION":"LR","MASTER_ID":23952,"metacyc":"3.5.1.85-RXN","compounds":"H2O + N-(2-phenylethyl)acetamide => 2-phenylethylamine + acetate"}
{"X":26751,"RHEA_ID":23954,"compounds":"2-phenylethylamine + acetate => H2O + N-(2-phenylethyl)acetamide"}
{"X":26752,"RHEA_ID":44516,"compounds":"1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoserine + H2O = (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphoserine + H(+)"}
{"X":26753,"RHEA_ID":34591,"DIRECTION":"UN","MASTER_ID":34591,"ec":"2.1.1.289","compounds":"Co-precorrin-7 + S-adenosyl-L-methionine = Co-precorrin-8X + H(+) + S-adenosyl-L-homocysteine"}
{"X":26754,"RHEA_ID":23957,"DIRECTION":"LR","MASTER_ID":23956,"metacyc":"2.4.1.41-RXN","compounds":"L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP"}
{"X":26755,"RHEA_ID":23958,"compounds":"3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP => L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine"}
{"X":26756,"RHEA_ID":44520,"compounds":"1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":26757,"RHEA_ID":34595,"compounds":"H(+) + isopentadecanoyl-CoA + L-serine = 3-dehydro-15-methylhexadecasphinganine + CO2 + CoA"}
{"X":26758,"RHEA_ID":23960,"DIRECTION":"UN","MASTER_ID":23960,"ec":"1.11.1.3","compounds":"H(+) + 2 H2O2 + hexadecanoate = CO2 + 3 H2O + pentadecanal"}
{"X":26759,"RHEA_ID":23961,"DIRECTION":"LR","MASTER_ID":23960,"metacyc":"FATTY-ACID-PEROXIDASE-RXN","compounds":"H(+) + 2 H2O2 + hexadecanoate => CO2 + 3 H2O + pentadecanal"}
{"X":26760,"RHEA_ID":23962,"compounds":"CO2 + 3 H2O + pentadecanal => H(+) + 2 H2O2 + hexadecanoate"}
{"X":26761,"RHEA_ID":44525,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-glycerol + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-glycerol + H(+)"}
{"X":26762,"RHEA_ID":23964,"DIRECTION":"UN","MASTER_ID":23964,"ec":"1.2.1.68","compounds":"(E)-coniferaldehyde + H2O + NADP(+) = 2 H(+) + NADPH + trans-ferulate"}
{"X":26763,"RHEA_ID":23965,"DIRECTION":"LR","MASTER_ID":23964,"metacyc":"RXN-1241","compounds":"(E)-coniferaldehyde + H2O + NADP(+) => 2 H(+) + NADPH + trans-ferulate"}
{"X":26764,"RHEA_ID":23966,"compounds":"2 H(+) + NADPH + trans-ferulate => (E)-coniferaldehyde + H2O + NADP(+)"}
{"X":26765,"RHEA_ID":44529,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+)"}
{"X":26766,"RHEA_ID":23968,"DIRECTION":"UN","MASTER_ID":23968,"ec":"1.2.1.68","compounds":"(E)-coniferaldehyde + H2O + NAD(+) = 2 H(+) + NADH + trans-ferulate"}
{"X":26767,"RHEA_ID":23969,"DIRECTION":"LR","MASTER_ID":23968,"metacyc":"RXN-1241","compounds":"(E)-coniferaldehyde + H2O + NAD(+) => 2 H(+) + NADH + trans-ferulate"}
{"X":26768,"RHEA_ID":23970,"compounds":"2 H(+) + NADH + trans-ferulate => (E)-coniferaldehyde + H2O + NAD(+)"}
{"X":26769,"RHEA_ID":44533,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphoethanolamine"}
{"X":26770,"RHEA_ID":23972,"DIRECTION":"UN","MASTER_ID":23972,"ec":"7.2.4.5","compounds":"(2E)-glutaconyl-CoA + H(+) + Na(+)(in) = (2E)-butenoyl-CoA + CO2 + Na(+)(out)"}
{"X":26771,"RHEA_ID":23973,"DIRECTION":"LR","MASTER_ID":23972,"metacyc":"GLUTACONYL-COA-DECARBOXYLASE-RXN","compounds":"(2E)-glutaconyl-CoA + H(+) + Na(+)(in) => (2E)-butenoyl-CoA + CO2 + Na(+)(out)"}
{"X":26772,"RHEA_ID":23974,"compounds":"(2E)-butenoyl-CoA + CO2 + Na(+)(out) => (2E)-glutaconyl-CoA + H(+) + Na(+)(in)"}
{"X":26773,"RHEA_ID":44537,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphoethanolamine"}
{"X":26774,"RHEA_ID":23976,"DIRECTION":"UN","MASTER_ID":23976,"ec":"6.5.1.4","compounds":"(RNA)-3'-(3'-phospho-ribonucleoside) + ATP = (RNA)-3'-(2',3'-cyclophospho)-ribonucleoside + AMP + diphosphate"}
{"X":26775,"RHEA_ID":23977,"DIRECTION":"LR","MASTER_ID":23976,"ecocyc":"RNA-3-PHOSPHATE-CYCLASE-RXN","metacyc":"RNA-3-PHOSPHATE-CYCLASE-RXN","compounds":"(RNA)-3'-(3'-phospho-ribonucleoside) + ATP => (RNA)-3'-(2',3'-cyclophospho)-ribonucleoside + AMP + diphosphate"}
{"X":26776,"RHEA_ID":23978,"compounds":"(RNA)-3'-(2',3'-cyclophospho)-ribonucleoside + AMP + diphosphate => (RNA)-3'-(3'-phospho-ribonucleoside) + ATP"}
{"X":26777,"RHEA_ID":44541,"compounds":"1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)"}
{"X":26778,"RHEA_ID":23980,"DIRECTION":"UN","MASTER_ID":23980,"ec":"3.2.1.54","compounds":"cyclomaltodextrin + H2O = linear maltodextrin"}
{"X":26779,"RHEA_ID":23981,"DIRECTION":"LR","MASTER_ID":23980,"metacyc":"CYCLOMALTODEXTRINASE-RXN","compounds":"cyclomaltodextrin + H2O => linear maltodextrin"}
{"X":26780,"RHEA_ID":23982,"compounds":"linear maltodextrin => cyclomaltodextrin + H2O"}
{"X":26781,"RHEA_ID":23984,"DIRECTION":"UN","MASTER_ID":23984,"ec":"1.3.1.21","compounds":"cholesterol + NADP(+) = cholesta-5,7-dien-3beta-ol + H(+) + NADPH"}
{"X":26782,"RHEA_ID":23985,"compounds":"cholesterol + NADP(+) => cholesta-5,7-dien-3beta-ol + H(+) + NADPH"}
{"X":26783,"RHEA_ID":34627,"compounds":"(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + H2O + 2 oxidized [adrenodoxin]"}
{"X":26784,"RHEA_ID":34628,"DIRECTION":"LR","MASTER_ID":34627,"metacyc":"1.2.1.40-RXN","compounds":"(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + H2O + 2 oxidized [adrenodoxin]"}
{"X":26785,"RHEA_ID":23988,"DIRECTION":"UN","MASTER_ID":23988,"ec":"2.6.1.83","compounds":"(2S,6S)-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O + L-glutamate"}
{"X":26786,"RHEA_ID":23989,"compounds":"(2S,6S)-2,6-diaminoheptanedioate + 2-oxoglutarate => (S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O + L-glutamate"}
{"X":26787,"RHEA_ID":34631,"DIRECTION":"UN","MASTER_ID":34631,"ec":"1.14.15.15","compounds":"5beta-cholestane-3alpha,7alpha,12alpha-triol + 5 H(+) + 3 O2 + 6 reduced [adrenodoxin] = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + 4 H2O + 6 oxidized [adrenodoxin]"}
{"X":26788,"RHEA_ID":34632,"DIRECTION":"LR","MASTER_ID":34631,"metacyc":"RXN-13690","compounds":"5beta-cholestane-3alpha,7alpha,12alpha-triol + 5 H(+) + 3 O2 + 6 reduced [adrenodoxin] => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + 4 H2O + 6 oxidized [adrenodoxin]"}
{"X":26789,"RHEA_ID":23992,"DIRECTION":"UN","MASTER_ID":23992,"ec":"2.3.1.63","metacyc":"2.3.1.63-RXN","compounds":"1-O-alkyl-sn-glycero-3-phosphocholine + an acyl-CoA = 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA"}
{"X":26790,"RHEA_ID":23993,"compounds":"1-O-alkyl-sn-glycero-3-phosphocholine + an acyl-CoA => 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA"}
{"X":26791,"RHEA_ID":34635,"DIRECTION":"UN","MASTER_ID":34635,"ec":"1.14.13.170","compounds":"1-deoxy-11-oxopentalenate + H(+) + NADPH + O2 = H2O + NADP(+) + pentalenolactone D"}
{"X":26792,"RHEA_ID":23996,"DIRECTION":"UN","MASTER_ID":23996,"ec":"3.6.1.9","compounds":"a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-phosphate + diphosphate + H(+)"}
{"X":26793,"RHEA_ID":23997,"DIRECTION":"LR","MASTER_ID":23996,"ecocyc":"3.6.1.19-RXN","metacyc":"3.6.1.19-RXN","compounds":"a ribonucleoside 5'-triphosphate + H2O => a ribonucleoside 5'-phosphate + diphosphate + H(+)"}
{"X":26794,"RHEA_ID":34639,"DIRECTION":"UN","MASTER_ID":34639,"ec":"1.14.13.171","compounds":"1-deoxy-11-oxopentalenate + H(+) + NADPH + O2 = H2O + NADP(+) + neopentalenolactone D"}
{"X":26795,"RHEA_ID":24000,"DIRECTION":"UN","MASTER_ID":24000,"ec":"2.1.1.63","compounds":"a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]"}
{"X":26796,"RHEA_ID":24001,"DIRECTION":"LR","MASTER_ID":24000,"ecocyc":"2.1.1.63-RXN","metacyc":"2.1.1.63-RXN","compounds":"a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] => a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]"}
{"X":26797,"RHEA_ID":34643,"DIRECTION":"UN","MASTER_ID":34643,"ec":"2.1.1.262","compounds":"2 S-adenosyl-L-methionine + squalene = 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + 2 H(+) + 2 S-adenosyl-L-homocysteine"}
{"X":26798,"RHEA_ID":24004,"DIRECTION":"UN","MASTER_ID":24004,"ec":"1.3.8.1","compounds":"butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":26799,"RHEA_ID":24005,"compounds":"butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":26800,"RHEA_ID":34647,"compounds":"S-adenosyl-L-methionine + squalene = 3-methyl-1,2-didehydro-2,3-dihydrosqualene + H(+) + S-adenosyl-L-homocysteine"}
{"X":26801,"RHEA_ID":34648,"DIRECTION":"LR","MASTER_ID":34647,"metacyc":"RXN-13284","compounds":"S-adenosyl-L-methionine + squalene => 3-methyl-1,2-didehydro-2,3-dihydrosqualene + H(+) + S-adenosyl-L-homocysteine"}
{"X":26802,"RHEA_ID":24008,"DIRECTION":"UN","MASTER_ID":24008,"ec":"2.7.3.6","metacyc":"HYPOTAUROCYAMINE-KINASE-RXN","compounds":"ATP + hypotaurocyamine = ADP + H(+) + N(omega)-phosphohypotaurocyamine"}
{"X":26803,"RHEA_ID":24009,"compounds":"ATP + hypotaurocyamine => ADP + H(+) + N(omega)-phosphohypotaurocyamine"}
{"X":26804,"RHEA_ID":34651,"compounds":"3-methyl-1,2-didehydro-2,3-dihydrosqualene + S-adenosyl-L-methionine = 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + H(+) + S-adenosyl-L-homocysteine"}
{"X":26805,"RHEA_ID":34652,"DIRECTION":"LR","MASTER_ID":34651,"metacyc":"RXN-13285","compounds":"3-methyl-1,2-didehydro-2,3-dihydrosqualene + S-adenosyl-L-methionine => 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + H(+) + S-adenosyl-L-homocysteine"}
{"X":26806,"RHEA_ID":24012,"DIRECTION":"UN","MASTER_ID":24012,"ec":"2.1.1.95","compounds":"gamma-tocopherol + S-adenosyl-L-methionine = (+)-alpha-tocopherol + H(+) + S-adenosyl-L-homocysteine"}
{"X":26807,"RHEA_ID":24013,"DIRECTION":"LR","MASTER_ID":24012,"metacyc":"TOCOPHEROL-O-METHYLTRANSFERASE-RXN","compounds":"gamma-tocopherol + S-adenosyl-L-methionine => (+)-alpha-tocopherol + H(+) + S-adenosyl-L-homocysteine"}
{"X":26808,"RHEA_ID":34655,"DIRECTION":"UN","MASTER_ID":34655,"ec":"2.1.1.263","compounds":"C30 botryococcene + 2 S-adenosyl-L-methionine = 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + 2 H(+) + 2 S-adenosyl-L-homocysteine"}
{"X":26809,"RHEA_ID":34656,"DIRECTION":"LR","MASTER_ID":34655,"metacyc":"RXN-13754","compounds":"C30 botryococcene + 2 S-adenosyl-L-methionine => 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + 2 H(+) + 2 S-adenosyl-L-homocysteine"}
{"X":26810,"RHEA_ID":24016,"DIRECTION":"UN","MASTER_ID":24016,"ec":"2.3.1.160","compounds":"16-epivellosimine + acetyl-CoA = CoA + vinorine"}
{"X":26811,"RHEA_ID":24017,"compounds":"16-epivellosimine + acetyl-CoA => CoA + vinorine"}
{"X":26812,"RHEA_ID":34659,"compounds":"C30 botryococcene + S-adenosyl-L-methionine = 3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine"}
{"X":26813,"RHEA_ID":34660,"DIRECTION":"LR","MASTER_ID":34659,"metacyc":"RXN-14258","compounds":"C30 botryococcene + S-adenosyl-L-methionine => 3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine"}
{"X":26814,"RHEA_ID":24020,"DIRECTION":"UN","MASTER_ID":24020,"ec":"4.3.2.1","compounds":"2-(N(omega)-L-arginino)succinate = fumarate + L-arginine"}
{"X":26815,"RHEA_ID":24021,"DIRECTION":"LR","MASTER_ID":24020,"reactome":"R-HSA-70573.3","compounds":"2-(N(omega)-L-arginino)succinate => fumarate + L-arginine"}
{"X":26816,"RHEA_ID":34663,"compounds":"20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + S-adenosyl-L-methionine = 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine"}
{"X":26817,"RHEA_ID":34664,"DIRECTION":"LR","MASTER_ID":34663,"metacyc":"RXN-13283","compounds":"20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + S-adenosyl-L-methionine => 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine"}
{"X":26818,"RHEA_ID":24024,"DIRECTION":"UN","MASTER_ID":24024,"ec":"2.6.1.115","compounds":"(2E,5S,6E,8E,10E)-1-aminododeca-2,6,8,10-tetraen-5-ol + pyruvate = (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + L-alanine"}
{"X":26819,"RHEA_ID":24025,"compounds":"(2E,5S,6E,8E,10E)-1-aminododeca-2,6,8,10-tetraen-5-ol + pyruvate => (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + L-alanine"}
{"X":26820,"RHEA_ID":34667,"compounds":"C30 botryococcene + S-adenosyl-L-methionine = 20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine"}
{"X":26821,"RHEA_ID":24027,"DIRECTION":"BI","MASTER_ID":24024,"metacyc":"RXN-18638","compounds":"(2E,5S,6E,8E,10E)-1-aminododeca-2,6,8,10-tetraen-5-ol + pyruvate <=> (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + L-alanine"}
{"X":26822,"RHEA_ID":24028,"DIRECTION":"UN","MASTER_ID":24028,"ec":"1.14.11.1","compounds":"2-oxoglutarate + 4-(trimethylamino)butanoate + O2 = carnitine + CO2 + succinate"}
{"X":26823,"RHEA_ID":24029,"DIRECTION":"LR","MASTER_ID":24028,"metacyc":"1.14.11.1-RXN","reactome":"R-HSA-71261.4","compounds":"2-oxoglutarate + 4-(trimethylamino)butanoate + O2 => carnitine + CO2 + succinate"}
{"X":26824,"RHEA_ID":34671,"compounds":"3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + S-adenosyl-L-methionine = 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine"}
{"X":26825,"RHEA_ID":34672,"DIRECTION":"LR","MASTER_ID":34671,"metacyc":"RXN-14259","compounds":"3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + S-adenosyl-L-methionine => 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine"}
{"X":26826,"RHEA_ID":24032,"DIRECTION":"UN","MASTER_ID":24032,"ec":"5.4.99.11","metacyc":"ISOMALTULOSE-SYNTHASE-RXN","compounds":"sucrose = 6-O-alpha-D-glucopyranosyl-D-fructose"}
{"X":26827,"RHEA_ID":24033,"compounds":"sucrose => 6-O-alpha-D-glucopyranosyl-D-fructose"}
{"X":26828,"RHEA_ID":34675,"DIRECTION":"UN","MASTER_ID":34675,"ec":"2.7.7.82","compounds":"CTP + N,N-diacetyllegionaminate = CMP-N,N-diacetyllegionaminate + diphosphate"}
{"X":26829,"RHEA_ID":34676,"DIRECTION":"LR","MASTER_ID":34675,"metacyc":"RXN-12239","compounds":"CTP + N,N-diacetyllegionaminate => CMP-N,N-diacetyllegionaminate + diphosphate"}
{"X":26830,"RHEA_ID":24036,"DIRECTION":"UN","MASTER_ID":24036,"ec":"2.7.4.4","compounds":"a ribonucleoside 5'-phosphate + ATP = a ribonucleoside 5'-diphosphate + ADP"}
{"X":26831,"RHEA_ID":24037,"DIRECTION":"LR","MASTER_ID":24036,"metacyc":"NUCLEOSIDE-PHOSPHATE-KINASE-RXN","compounds":"a ribonucleoside 5'-phosphate + ATP => a ribonucleoside 5'-diphosphate + ADP"}
{"X":26832,"RHEA_ID":34679,"DIRECTION":"UN","MASTER_ID":34679,"ec":"2.7.8.37","compounds":"ATP + methylphosphonate = adenine + alpha-D-ribose 1-methylphosphonate 5-triphosphate"}
{"X":26833,"RHEA_ID":34680,"DIRECTION":"LR","MASTER_ID":34679,"metacyc":"RXN0-6732","compounds":"ATP + methylphosphonate => adenine + alpha-D-ribose 1-methylphosphonate 5-triphosphate"}
{"X":26834,"RHEA_ID":24040,"DIRECTION":"UN","MASTER_ID":24040,"ec":"1.6.2.4","compounds":"NADPH + 2 oxidized [cytochrome P450] = H(+) + NADP(+) + 2 reduced [cytochrome P450]"}
{"X":26835,"RHEA_ID":24041,"DIRECTION":"LR","MASTER_ID":24040,"metacyc":"NADPH--FERRIHEMOPROTEIN-REDUCTASE-RXN","compounds":"NADPH + 2 oxidized [cytochrome P450] => H(+) + NADP(+) + 2 reduced [cytochrome P450]"}
{"X":26836,"RHEA_ID":24042,"compounds":"H(+) + NADP(+) + 2 reduced [cytochrome P450] => NADPH + 2 oxidized [cytochrome P450]"}
{"X":26837,"RHEA_ID":24043,"compounds":"NADPH + 2 oxidized [cytochrome P450] <=> H(+) + NADP(+) + 2 reduced [cytochrome P450]"}
{"X":26838,"RHEA_ID":24044,"DIRECTION":"UN","MASTER_ID":24044,"ec":"1.13.11.8","compounds":"3,4-dihydroxybenzoate + O2 = 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)"}
{"X":26839,"RHEA_ID":24045,"DIRECTION":"LR","MASTER_ID":24044,"metacyc":"PROTOCATECHUATE-45-DIOXYGENASE-RXN","compounds":"3,4-dihydroxybenzoate + O2 => 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)"}
{"X":26840,"RHEA_ID":24046,"compounds":"4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+) => 3,4-dihydroxybenzoate + O2"}
{"X":26841,"RHEA_ID":34688,"compounds":"AH2 + N-acyl-15-methylhexadecasphinganine + O2 => A + 2 H2O + N-acyl-15-methylhexadecasphing-4-enine"}
{"X":26842,"RHEA_ID":24048,"DIRECTION":"UN","MASTER_ID":24048,"ec":"2.4.1.7","compounds":"phosphate + sucrose = alpha-D-glucose 1-phosphate + D-fructose"}
{"X":26843,"RHEA_ID":24049,"DIRECTION":"LR","MASTER_ID":24048,"metacyc":"SUCROSE-PHOSPHORYLASE-RXN","compounds":"phosphate + sucrose => alpha-D-glucose 1-phosphate + D-fructose"}
{"X":26844,"RHEA_ID":34691,"DIRECTION":"UN","MASTER_ID":34691,"ec":"4.2.1.54","compounds":"(R)-lactoyl-CoA = acryloyl-CoA + H2O"}
{"X":26845,"RHEA_ID":34692,"compounds":"(R)-lactoyl-CoA => acryloyl-CoA + H2O"}
{"X":26846,"RHEA_ID":24052,"DIRECTION":"UN","MASTER_ID":24052,"ec":"1.5.5.1","compounds":"a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":26847,"RHEA_ID":24053,"DIRECTION":"LR","MASTER_ID":24052,"metacyc":"RXN66-550","compounds":"a ubiquinone + reduced [electron-transfer flavoprotein] => a ubiquinol + H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":26848,"RHEA_ID":34695,"DIRECTION":"UN","MASTER_ID":34695,"ec":"4.2.3.135","compounds":"(2E,6E)-farnesyl diphosphate = Delta(6)-protoilludene + diphosphate"}
{"X":26849,"RHEA_ID":24056,"DIRECTION":"UN","MASTER_ID":24056,"ec":"3.1.3.25","compounds":"a myo-inositol phosphate + H2O = myo-inositol + phosphate"}
{"X":26850,"RHEA_ID":24057,"DIRECTION":"LR","MASTER_ID":24056,"metacyc":"RXN-10949","compounds":"a myo-inositol phosphate + H2O => myo-inositol + phosphate"}
{"X":26851,"RHEA_ID":24058,"compounds":"myo-inositol + phosphate => a myo-inositol phosphate + H2O"}
{"X":26852,"RHEA_ID":24060,"compounds":"N-hydroxy-L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase]"}
{"X":26853,"RHEA_ID":24061,"DIRECTION":"LR","MASTER_ID":24060,"metacyc":"RXN-7748","compounds":"N-hydroxy-L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase]"}
{"X":26854,"RHEA_ID":34703,"DIRECTION":"UN","MASTER_ID":34703,"ec":"4.2.3.137","compounds":"(2E,6E)-farnesyl diphosphate = (E)-2-epi-beta-caryophyllene + diphosphate"}
{"X":26855,"RHEA_ID":34704,"DIRECTION":"LR","MASTER_ID":34703,"metacyc":"RXN-13763","compounds":"(2E,6E)-farnesyl diphosphate => (E)-2-epi-beta-caryophyllene + diphosphate"}
{"X":26856,"RHEA_ID":24064,"DIRECTION":"UN","MASTER_ID":24064,"ec":"4.2.1.24","compounds":"2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen"}
{"X":26857,"RHEA_ID":24065,"DIRECTION":"LR","MASTER_ID":24064,"macie":"M0230","reactome":"R-HSA-189439.2","compounds":"2 5-aminolevulinate => H(+) + 2 H2O + porphobilinogen"}
{"X":26858,"RHEA_ID":24066,"compounds":"H(+) + 2 H2O + porphobilinogen => 2 5-aminolevulinate"}
{"X":26859,"RHEA_ID":34708,"DIRECTION":"LR","MASTER_ID":34707,"metacyc":"RXN0-6734","compounds":"AH2 + alpha-D-ribose 1-methylphosphonate 5-phosphate + S-adenosyl-L-methionine => 5'-deoxyadenosine + A + alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H(+) + L-methionine + methane"}
{"X":26860,"RHEA_ID":24068,"DIRECTION":"UN","MASTER_ID":24068,"ec":"1.14.13.22","compounds":"cyclohexanone + H(+) + NADPH + O2 = H2O + hexano-6-lactone + NADP(+)"}
{"X":26861,"RHEA_ID":24069,"DIRECTION":"LR","MASTER_ID":24068,"metacyc":"CYCLOHEXANONE-MONOOXYGENASE-RXN","compounds":"cyclohexanone + H(+) + NADPH + O2 => H2O + hexano-6-lactone + NADP(+)"}
{"X":26862,"RHEA_ID":24070,"compounds":"H2O + hexano-6-lactone + NADP(+) => cyclohexanone + H(+) + NADPH + O2"}
{"X":26863,"RHEA_ID":44634,"compounds":"2-(3,5-dihydroxyphenyl)-2-oxoacetate + CoA + H(+) => (3,5-dihydroxyphenyl)acetyl-CoA + O2"}
{"X":26864,"RHEA_ID":24072,"compounds":"(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate = 12,13-epoxy-(9Z,11E,15Z)-octadecatrienoate + H2O"}
{"X":26865,"RHEA_ID":24073,"compounds":"(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => 12,13-epoxy-(9Z,11E,15Z)-octadecatrienoate + H2O"}
{"X":26866,"RHEA_ID":24074,"compounds":"12,13-epoxy-(9Z,11E,15Z)-octadecatrienoate + H2O => (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate"}
{"X":26867,"RHEA_ID":34716,"compounds":"15-methylhexadecasphing-4-enine + ATP => 15-methylhexadecasphing-4-enine 1-phosphate + ADP + H(+)"}
{"X":26868,"RHEA_ID":24076,"DIRECTION":"UN","MASTER_ID":24076,"ec":"1.1.1.145","compounds":"a 3beta-hydroxy-Delta(5)-steroid + NAD(+) = a 3-oxo-Delta(5)-steroid + H(+) + NADH"}
{"X":26869,"RHEA_ID":24077,"compounds":"a 3beta-hydroxy-Delta(5)-steroid + NAD(+) => a 3-oxo-Delta(5)-steroid + H(+) + NADH"}
{"X":26870,"RHEA_ID":24078,"compounds":"a 3-oxo-Delta(5)-steroid + H(+) + NADH => a 3beta-hydroxy-Delta(5)-steroid + NAD(+)"}
{"X":26871,"RHEA_ID":44642,"compounds":"a 2'-deoxyribonucleoside 5'-triphosphate + ADP => a 2'-deoxyribonucleoside 5'-diphosphate + ATP"}
{"X":26872,"RHEA_ID":24080,"DIRECTION":"UN","MASTER_ID":24080,"ec":"6.1.1.2","compounds":"ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)"}
{"X":26873,"RHEA_ID":24081,"DIRECTION":"LR","MASTER_ID":24080,"ecocyc":"TRYPTOPHAN--TRNA-LIGASE-RXN","metacyc":"TRYPTOPHAN--TRNA-LIGASE-RXN","compounds":"ATP + L-tryptophan + tRNA(Trp) => AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)"}
{"X":26874,"RHEA_ID":24082,"compounds":"AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp) => ATP + L-tryptophan + tRNA(Trp)"}
{"X":26875,"RHEA_ID":44646,"compounds":"a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+) => a 2'-deoxyribonucleoside 5'-triphosphate + H2O"}
{"X":26876,"RHEA_ID":24084,"compounds":"all-trans-zeaxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = all-trans-antheraxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":26877,"RHEA_ID":24085,"DIRECTION":"LR","MASTER_ID":24084,"metacyc":"RXN-13193","compounds":"all-trans-zeaxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => all-trans-antheraxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":26878,"RHEA_ID":24086,"compounds":"all-trans-antheraxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => all-trans-zeaxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":26879,"RHEA_ID":34728,"compounds":"H2O + N-acyl-15-methylhexadecasphinganine => 15-methylhexadecasphinganine + a carboxylate"}
{"X":26880,"RHEA_ID":24092,"DIRECTION":"UN","MASTER_ID":24092,"ec":"1.21.3.4","compounds":"2 H(+) + O2 + 2 sulochrin = 2 (2S)-bisdechlorogeodin + 2 H2O"}
{"X":26881,"RHEA_ID":24093,"DIRECTION":"LR","MASTER_ID":24092,"metacyc":"1.10.3.7-RXN","compounds":"2 H(+) + O2 + 2 sulochrin => 2 (2S)-bisdechlorogeodin + 2 H2O"}
{"X":26882,"RHEA_ID":24094,"compounds":"2 (2S)-bisdechlorogeodin + 2 H2O => 2 H(+) + O2 + 2 sulochrin"}
{"X":26883,"RHEA_ID":34732,"compounds":"15-methylhexadecasphing-4-enine + an acyl-CoA => CoA + H(+) + N-acyl-15-methylhexadecasphing-4-enine"}
{"X":26884,"RHEA_ID":24096,"DIRECTION":"UN","MASTER_ID":24096,"ec":"2.1.1.78","compounds":"isoorientin + S-adenosyl-L-methionine = H(+) + isoscoparin + S-adenosyl-L-homocysteine"}
{"X":26885,"RHEA_ID":24097,"DIRECTION":"LR","MASTER_ID":24096,"metacyc":"ISOORIENTIN-3-O-METHYLTRANSFERASE-RXN","compounds":"isoorientin + S-adenosyl-L-methionine => H(+) + isoscoparin + S-adenosyl-L-homocysteine"}
{"X":26886,"RHEA_ID":24098,"compounds":"H(+) + isoscoparin + S-adenosyl-L-homocysteine => isoorientin + S-adenosyl-L-methionine"}
{"X":26887,"RHEA_ID":34736,"compounds":"an acyl-CoA + sphinganine => an N-acylsphinganine + CoA + H(+)"}
{"X":26888,"RHEA_ID":24100,"DIRECTION":"UN","MASTER_ID":24100,"ec":"3.1.8.2","compounds":"diisopropyl fluorophosphate + H2O = diisopropyl phosphate + fluoride + 2 H(+)"}
{"X":26889,"RHEA_ID":24101,"compounds":"diisopropyl fluorophosphate + H2O => diisopropyl phosphate + fluoride + 2 H(+)"}
{"X":26890,"RHEA_ID":24102,"compounds":"diisopropyl phosphate + fluoride + 2 H(+) => diisopropyl fluorophosphate + H2O"}
{"X":26891,"RHEA_ID":34740,"compounds":"H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine => H(+) + N-acyl-15-methylhexadecasphing-4-enine + phosphocholine"}
{"X":26892,"RHEA_ID":24104,"DIRECTION":"UN","MASTER_ID":24104,"ec":"2.4.2.29","compounds":"7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine"}
{"X":26893,"RHEA_ID":24105,"DIRECTION":"LR","MASTER_ID":24104,"ecocyc":"RXN0-1321","metacyc":"RXN0-1321","compounds":"7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA => 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine"}
{"X":26894,"RHEA_ID":24106,"compounds":"7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine => 7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA"}
{"X":26895,"RHEA_ID":34744,"compounds":"15-methylhexadecasphinganine 1-phosphate => 13-methyltetradecanal + phosphoethanolamine"}
{"X":26896,"RHEA_ID":24108,"DIRECTION":"UN","MASTER_ID":24108,"ec":"3.5.1.36","metacyc":"N-METHYL-2-OXOGLUTARAMATE-HYDROLASE-RXN","compounds":"H2O + N-methyl-2-oxoglutaramate = 2-oxoglutarate + methylamine"}
{"X":26897,"RHEA_ID":24109,"compounds":"H2O + N-methyl-2-oxoglutaramate => 2-oxoglutarate + methylamine"}
{"X":26898,"RHEA_ID":24110,"compounds":"2-oxoglutarate + methylamine => H2O + N-methyl-2-oxoglutaramate"}
{"X":26899,"RHEA_ID":44670,"compounds":"4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+) => 4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol"}
{"X":26900,"RHEA_ID":24112,"DIRECTION":"UN","MASTER_ID":24112,"ec":"1.8.3.3","compounds":"2 glutathione + O2 = glutathione disulfide + H2O2"}
{"X":26901,"RHEA_ID":24113,"DIRECTION":"LR","MASTER_ID":24112,"metacyc":"GLUTATHIONE-OXIDASE-RXN","compounds":"2 glutathione + O2 => glutathione disulfide + H2O2"}
{"X":26902,"RHEA_ID":24114,"compounds":"glutathione disulfide + H2O2 => 2 glutathione + O2"}
{"X":26903,"RHEA_ID":44674,"compounds":"a 1-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+) => 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O"}
{"X":26904,"RHEA_ID":24116,"DIRECTION":"UN","MASTER_ID":24116,"ec":"4.2.3.25","compounds":"(2E)-geranyl diphosphate + H2O = (S)-linalool + diphosphate"}
{"X":26905,"RHEA_ID":24117,"DIRECTION":"LR","MASTER_ID":24116,"metacyc":"4.2.3.25-RXN","compounds":"(2E)-geranyl diphosphate + H2O => (S)-linalool + diphosphate"}
{"X":26906,"RHEA_ID":24118,"compounds":"(S)-linalool + diphosphate => (2E)-geranyl diphosphate + H2O"}
{"X":26907,"RHEA_ID":34756,"compounds":"H2O + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine => D-glucose + N-acyl-15-methylhexadecasphing-4-enine"}
{"X":26908,"RHEA_ID":24120,"DIRECTION":"UN","MASTER_ID":24120,"ec":"1.14.13.34","compounds":"H(+) + leukotriene E4 + NADPH + O2 = 20-hydroxy-leukotriene E4 + H2O + NADP(+)"}
{"X":26909,"RHEA_ID":34758,"compounds":"H2O + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine <=> D-glucose + N-acyl-15-methylhexadecasphing-4-enine"}
{"X":26910,"RHEA_ID":24122,"compounds":"20-hydroxy-leukotriene E4 + H2O + NADP(+) => H(+) + leukotriene E4 + NADPH + O2"}
{"X":26911,"RHEA_ID":34760,"DIRECTION":"LR","MASTER_ID":34759,"ecocyc":"TRANS-RXN0-477","compounds":"ATP + glycerol 2-phosphate(out) + H2O => ADP + glycerol 2-phosphate(in) + H(+) + phosphate"}
{"X":26912,"RHEA_ID":24124,"compounds":"all-trans-retinal = 11-cis-retinal"}
{"X":26913,"RHEA_ID":24125,"compounds":"all-trans-retinal => 11-cis-retinal"}
{"X":26914,"RHEA_ID":24126,"compounds":"11-cis-retinal => all-trans-retinal"}
{"X":26915,"RHEA_ID":34764,"DIRECTION":"LR","MASTER_ID":34763,"ecocyc":"TRANS-RXN0-499","compounds":"(S,S)-tartrate(out) + succinate(in) => (S,S)-tartrate(in) + succinate(out)"}
{"X":26916,"RHEA_ID":24128,"DIRECTION":"UN","MASTER_ID":24128,"ec":"3.6.3.11","compounds":"ATP + chloride(out) + H2O = ADP + chloride(in) + H(+) + phosphate"}
{"X":26917,"RHEA_ID":34766,"compounds":"(S,S)-tartrate(out) + succinate(in) <=> (S,S)-tartrate(in) + succinate(out)"}
{"X":26918,"RHEA_ID":24130,"compounds":"ADP + chloride(in) + H(+) + phosphate => ATP + chloride(out) + H2O"}
{"X":26919,"RHEA_ID":24131,"compounds":"ATP + chloride(out) + H2O <=> ADP + chloride(in) + H(+) + phosphate"}
{"X":26920,"RHEA_ID":24132,"DIRECTION":"UN","MASTER_ID":24132,"ec":"5.4.99.9","compounds":"UDP-alpha-D-galactose = UDP-alpha-D-galactofuranose"}
{"X":26921,"RHEA_ID":34770,"DIRECTION":"BI","MASTER_ID":34767,"ecocyc":"RXN-6321","compounds":"5,10-methenyltetrahydrofolate + H2O <=> 5-formyltetrahydrofolate + H(+)"}
{"X":26922,"RHEA_ID":24134,"compounds":"UDP-alpha-D-galactofuranose => UDP-alpha-D-galactose"}
{"X":26923,"RHEA_ID":34772,"compounds":"a 3beta-hydroxysteroid-4alpha-carboxylate + NADP(+) => a 3-oxosteroid + CO2 + NADPH"}
{"X":26924,"RHEA_ID":24136,"DIRECTION":"UN","MASTER_ID":24136,"ec":"2.8.2.3","compounds":"3'-phosphoadenylyl sulfate + a primary amine = a sulfamate + adenosine 3',5'-bisphosphate + 2 H(+)"}
{"X":26925,"RHEA_ID":44696,"compounds":"a 2-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine"}
{"X":26926,"RHEA_ID":24138,"compounds":"a sulfamate + adenosine 3',5'-bisphosphate + 2 H(+) => 3'-phosphoadenylyl sulfate + a primary amine"}
{"X":26927,"RHEA_ID":34775,"DIRECTION":"UN","MASTER_ID":34775,"ec":"1.1.1.418","compounds":"a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(+) = a 3-oxosteroid + CO2 + NADH"}
{"X":26928,"RHEA_ID":24140,"DIRECTION":"UN","MASTER_ID":24140,"ec":"2.1.1.185","compounds":"guanosine(2251) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(2251) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":26929,"RHEA_ID":34776,"DIRECTION":"LR","MASTER_ID":34775,"metacyc":"RXN-20374","compounds":"a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(+) => a 3-oxosteroid + CO2 + NADH"}
{"X":26930,"RHEA_ID":24142,"compounds":"2'-O-methylguanosine(2251) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(2251) in 23S rRNA + S-adenosyl-L-methionine"}
{"X":26931,"RHEA_ID":24143,"compounds":"guanosine(2251) in 23S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(2251) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":26932,"RHEA_ID":24144,"DIRECTION":"UN","MASTER_ID":24144,"ec":"4.2.1.57","compounds":"3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O"}
{"X":26933,"RHEA_ID":34779,"DIRECTION":"UN","MASTER_ID":34779,"ec":"1.1.1.213","compounds":"a 3alpha-hydroxysteroid + NAD(+) = a 3-oxosteroid + H(+) + NADH"}
{"X":26934,"RHEA_ID":24146,"DIRECTION":"RL","MASTER_ID":24144,"metacyc":"ISOHEXENYLGLUTACONYL-COA-HYDRATASE-RXN","compounds":"3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O => 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA"}
{"X":26935,"RHEA_ID":34780,"compounds":"a 3alpha-hydroxysteroid + NAD(+) => a 3-oxosteroid + H(+) + NADH"}
{"X":26936,"RHEA_ID":24148,"DIRECTION":"UN","MASTER_ID":24148,"ec":"1.2.7.6","compounds":"D-glyceraldehyde 3-phosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2R)-3-phosphoglycerate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":26937,"RHEA_ID":44708,"compounds":"a 1-acyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine"}
{"X":26938,"RHEA_ID":24150,"compounds":"(2R)-3-phosphoglycerate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => D-glyceraldehyde 3-phosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":26939,"RHEA_ID":34783,"DIRECTION":"UN","MASTER_ID":34783,"ec":"1.1.1.50","compounds":"a 3alpha-hydroxysteroid + NADP(+) = a 3-oxosteroid + H(+) + NADPH"}
{"X":26940,"RHEA_ID":24152,"DIRECTION":"UN","MASTER_ID":24152,"ec":"2.7.1.25","compounds":"adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)"}
{"X":26941,"RHEA_ID":34784,"compounds":"a 3alpha-hydroxysteroid + NADP(+) => a 3-oxosteroid + H(+) + NADPH"}
{"X":26942,"RHEA_ID":24154,"compounds":"3'-phosphoadenylyl sulfate + ADP + H(+) => adenosine 5'-phosphosulfate + ATP"}
{"X":26943,"RHEA_ID":44714,"compounds":"a 1-acylglycerol + a fatty acid + H(+) => a 1,2-diacylglycerol + H2O"}
{"X":26944,"RHEA_ID":24156,"DIRECTION":"UN","MASTER_ID":24156,"ec":"2.7.2.14","metacyc":"BRANCHED-CHAIN-FATTY-ACID-KINASE-RXN","compounds":"2-methylpropanoate + ATP = 2-methylpropanoyl phosphate + ADP"}
{"X":26945,"RHEA_ID":24157,"compounds":"2-methylpropanoate + ATP => 2-methylpropanoyl phosphate + ADP"}
{"X":26946,"RHEA_ID":24158,"compounds":"2-methylpropanoyl phosphate + ADP => 2-methylpropanoate + ATP"}
{"X":26947,"RHEA_ID":34790,"DIRECTION":"BI","MASTER_ID":34787,"metacyc":"RXN-13686","compounds":"a 3beta-hydroxysteroid + NADP(+) <=> a 3-oxosteroid + H(+) + NADPH"}
{"X":26948,"RHEA_ID":24160,"DIRECTION":"UN","MASTER_ID":24160,"ec":"1.1.3.9","compounds":"D-galactose + O2 = D-galacto-hexodialdose + H2O2"}
{"X":26949,"RHEA_ID":34792,"DIRECTION":"LR","MASTER_ID":34791,"metacyc":"RXN-10824","compounds":"2-hydroxyethylphosphonate + O2 => formate + H(+) + hydroxymethylphosphonate"}
{"X":26950,"RHEA_ID":24162,"compounds":"D-galacto-hexodialdose + H2O2 => D-galactose + O2"}
{"X":26951,"RHEA_ID":44722,"compounds":"a 1-acyl-sn-glycerol + H(+) + phosphocholine => a 1-acyl-sn-glycero-3-phosphocholine + H2O"}
{"X":26952,"RHEA_ID":24164,"DIRECTION":"UN","MASTER_ID":24164,"ec":"1.8.4.12","compounds":"[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]"}
{"X":26953,"RHEA_ID":34796,"DIRECTION":"LR","MASTER_ID":34795,"metacyc":"RXN0-6710","compounds":"alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O => alpha-D-ribose 1,5-bisphosphate + H(+)"}
{"X":26954,"RHEA_ID":24166,"compounds":"[thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein] => [thioredoxin]-disulfide + H2O + L-methionyl-[protein]"}
{"X":26955,"RHEA_ID":24168,"DIRECTION":"UN","MASTER_ID":24168,"ec":"2.4.1.135","compounds":"3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP"}
{"X":26956,"RHEA_ID":34800,"DIRECTION":"LR","MASTER_ID":34799,"metacyc":"RXN0-6512","compounds":"2,3-didehydroadipoyl-CoA + acetyl-CoA => 3-oxo-5,6-didehydrosuberyl-CoA + CoA"}
{"X":26957,"RHEA_ID":24170,"compounds":"3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate"}
{"X":26958,"RHEA_ID":24172,"DIRECTION":"UN","MASTER_ID":24172,"ec":"1.3.99.6","compounds":"A + a 3-oxo-5beta-steroid = a 3-oxo-Delta(4)-steroid + AH2"}
{"X":26959,"RHEA_ID":34804,"compounds":"2 4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA => bisdemethoxycurcumin + 2 CO2 + 3 CoA"}
{"X":26960,"RHEA_ID":24174,"compounds":"a 3-oxo-Delta(4)-steroid + AH2 => A + a 3-oxo-5beta-steroid"}
{"X":26961,"RHEA_ID":44734,"compounds":"(9Z,12Z)-octadecadienoate + glycerol + H(+) => 2-(9Z,12Z-octadecadienoyl)-glycerol + H2O"}
{"X":26962,"RHEA_ID":24176,"DIRECTION":"UN","MASTER_ID":24176,"ec":"2.8.1.4","compounds":"[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":26963,"RHEA_ID":34808,"DIRECTION":"LR","MASTER_ID":34807,"metacyc":"RXN-8275","compounds":"(R)-dihydrocamalexate + O2 + reduced [NADPH--hemoprotein reductase] => camalexin + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":26964,"RHEA_ID":24178,"compounds":"[ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] => [ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":26965,"RHEA_ID":44738,"DIRECTION":"RL","MASTER_ID":44736,"ecocyc":"RXN-15943","metacyc":"RXN-15943","compounds":"3-hydroxy-2,4-pentanedione 5-phosphate + CoA => acetyl-CoA + dihydroxyacetone phosphate"}
{"X":26966,"RHEA_ID":24180,"compounds":"2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein]"}
{"X":26967,"RHEA_ID":34812,"compounds":"NADP(+) + tetrahydrocurcumin => dihydrocurcumin + H(+) + NADPH"}
{"X":26968,"RHEA_ID":24182,"compounds":"CoA + H(+) + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] => 2-hydroxyisobutanoyl-CoA + L-lysyl-[protein]"}
{"X":26969,"RHEA_ID":24183,"compounds":"2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] <=> CoA + H(+) + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein]"}
{"X":26970,"RHEA_ID":24184,"DIRECTION":"UN","MASTER_ID":24184,"ec":"4.1.1.55","compounds":"4,5-dihydroxyphthalate + H(+) = 3,4-dihydroxybenzoate + CO2"}
{"X":26971,"RHEA_ID":24185,"compounds":"4,5-dihydroxyphthalate + H(+) => 3,4-dihydroxybenzoate + CO2"}
{"X":26972,"RHEA_ID":24186,"compounds":"3,4-dihydroxybenzoate + CO2 => 4,5-dihydroxyphthalate + H(+)"}
{"X":26973,"RHEA_ID":34818,"compounds":"2 NADP(+) + tetrahydrocurcumin <=> curcumin + 2 H(+) + 2 NADPH"}
{"X":26974,"RHEA_ID":24188,"DIRECTION":"UN","MASTER_ID":24188,"ec":"1.3.1.60","compounds":"cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD(+) = 1,2-dihydroxydibenzothiophene + H(+) + NADH"}
{"X":26975,"RHEA_ID":34820,"compounds":"dihydrocurcumin + NADP(+) => curcumin + H(+) + NADPH"}
{"X":26976,"RHEA_ID":24190,"compounds":"1,2-dihydroxydibenzothiophene + H(+) + NADH => cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD(+)"}
{"X":26977,"RHEA_ID":34822,"compounds":"dihydrocurcumin + NADP(+) <=> curcumin + H(+) + NADPH"}
{"X":26978,"RHEA_ID":24192,"DIRECTION":"UN","MASTER_ID":24192,"ec":"1.4.1.12","compounds":"(2R,4S)-2,4-diaminopentanoate + H2O + NADP(+) = (2R)-2-amino-4-oxopentanoate + H(+) + NADPH + NH4(+)"}
{"X":26979,"RHEA_ID":24193,"DIRECTION":"LR","MASTER_ID":24192,"metacyc":"24-DIAMINOPENTANOATE-DEHYDROGENASE-RXN","compounds":"(2R,4S)-2,4-diaminopentanoate + H2O + NADP(+) => (2R)-2-amino-4-oxopentanoate + H(+) + NADPH + NH4(+)"}
{"X":26980,"RHEA_ID":24194,"compounds":"(2R)-2-amino-4-oxopentanoate + H(+) + NADPH + NH4(+) => (2R,4S)-2,4-diaminopentanoate + H2O + NADP(+)"}
{"X":26981,"RHEA_ID":44754,"compounds":"6-methoxy-3-methyl-2-all-trans-hexaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine => 2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine"}
{"X":26982,"RHEA_ID":24196,"DIRECTION":"UN","MASTER_ID":24196,"ec":"1.4.1.12","compounds":"(2R,4S)-2,4-diaminopentanoate + H2O + NAD(+) = (2R)-2-amino-4-oxopentanoate + H(+) + NADH + NH4(+)"}
{"X":26983,"RHEA_ID":34828,"compounds":"H(+) + N-acyl-15-methylhexadecasphinganine + NADPH + O2 => H2O + N-acyl-4-hydroxy-15-methylhexadecasphinganine + NADP(+)"}
{"X":26984,"RHEA_ID":24197,"DIRECTION":"LR","MASTER_ID":24196,"metacyc":"24-DIAMINOPENTANOATE-DEHYDROGENASE-RXN","compounds":"(2R,4S)-2,4-diaminopentanoate + H2O + NAD(+) => (2R)-2-amino-4-oxopentanoate + H(+) + NADH + NH4(+)"}
{"X":26985,"RHEA_ID":24197,"DIRECTION":"LR","MASTER_ID":24196,"metacyc":"RXN-18499","compounds":"(2R,4S)-2,4-diaminopentanoate + H2O + NAD(+) => (2R)-2-amino-4-oxopentanoate + H(+) + NADH + NH4(+)"}
{"X":26986,"RHEA_ID":24198,"compounds":"(2R)-2-amino-4-oxopentanoate + H(+) + NADH + NH4(+) => (2R,4S)-2,4-diaminopentanoate + H2O + NAD(+)"}
{"X":26987,"RHEA_ID":34832,"compounds":"H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate => N-acyl-15-methylhexadecasphing-4-enine + phosphate"}
{"X":26988,"RHEA_ID":24200,"DIRECTION":"UN","MASTER_ID":24200,"ec":"4.1.1.24","compounds":"4-aminobenzoate + H(+) = aniline + CO2"}
{"X":26989,"RHEA_ID":24201,"compounds":"4-aminobenzoate + H(+) => aniline + CO2"}
{"X":26990,"RHEA_ID":24202,"compounds":"aniline + CO2 => 4-aminobenzoate + H(+)"}
{"X":26991,"RHEA_ID":34836,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-4-hydroxy-15-methylhexadecasphinganine => a 1,2-diacyl-sn-glycerol + N-acyl-4-hydroxy-15-methylhexadecasphinganine-1-phosphocholine"}
{"X":26992,"RHEA_ID":24204,"DIRECTION":"UN","MASTER_ID":24204,"ec":"2.3.3.15","compounds":"acetyl phosphate + H(+) + sulfite = phosphate + sulfoacetaldehyde"}
{"X":26993,"RHEA_ID":24205,"compounds":"acetyl phosphate + H(+) + sulfite => phosphate + sulfoacetaldehyde"}
{"X":26994,"RHEA_ID":24206,"DIRECTION":"RL","MASTER_ID":24204,"metacyc":"RXN-2364","compounds":"phosphate + sulfoacetaldehyde => acetyl phosphate + H(+) + sulfite"}
{"X":26995,"RHEA_ID":34840,"DIRECTION":"LR","MASTER_ID":34839,"metacyc":"RXN-11","compounds":"4 H(+) + 5 malonyl-CoA => 5,7-dihydroxy-2-methyl-4H-chromen-4-one + 5 CO2 + 5 CoA + H2O"}
{"X":26996,"RHEA_ID":24208,"DIRECTION":"UN","MASTER_ID":24208,"ec":"1.1.1.292","compounds":"1,5-anhydro-D-mannitol + NADP(+) = 1,5-anhydro-D-fructose + H(+) + NADPH"}
{"X":26997,"RHEA_ID":24209,"compounds":"1,5-anhydro-D-mannitol + NADP(+) => 1,5-anhydro-D-fructose + H(+) + NADPH"}
{"X":26998,"RHEA_ID":24210,"compounds":"1,5-anhydro-D-fructose + H(+) + NADPH => 1,5-anhydro-D-mannitol + NADP(+)"}
{"X":26999,"RHEA_ID":34844,"DIRECTION":"LR","MASTER_ID":34843,"ecocyc":"RXN0-6368","metacyc":"RXN0-6368","compounds":"7,8-dihydromonapterin 3'-triphosphate + 3 H2O => 7,8-dihydromonapterin + 2 H(+) + 3 phosphate"}
{"X":27000,"RHEA_ID":24212,"DIRECTION":"UN","MASTER_ID":24212,"ec":"2.7.1.50","compounds":"5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)"}
{"X":27001,"RHEA_ID":24213,"DIRECTION":"LR","MASTER_ID":24212,"ecocyc":"THIAZOLSYN3-RXN","metacyc":"THIAZOLSYN3-RXN","compounds":"5-(2-hydroxyethyl)-4-methylthiazole + ATP => 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)"}
{"X":27002,"RHEA_ID":24214,"compounds":"4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+) => 5-(2-hydroxyethyl)-4-methylthiazole + ATP"}
{"X":27003,"RHEA_ID":34848,"DIRECTION":"LR","MASTER_ID":34847,"ecocyc":"RXN0-6367","metacyc":"RXN0-6367","compounds":"7,8-dihydromonapterin + H(+) + NADPH => 5,6,7,8-tetrahydromonapterin + NADP(+)"}
{"X":27004,"RHEA_ID":24216,"DIRECTION":"UN","MASTER_ID":24216,"ec":"1.2.1.94","compounds":"(2E,6E)-farnesal + H2O + NAD(+) = (2E,6E)-farnesoate + 2 H(+) + NADH"}
{"X":27005,"RHEA_ID":24217,"DIRECTION":"LR","MASTER_ID":24216,"metacyc":"RXN-11619","compounds":"(2E,6E)-farnesal + H2O + NAD(+) => (2E,6E)-farnesoate + 2 H(+) + NADH"}
{"X":27006,"RHEA_ID":24218,"compounds":"(2E,6E)-farnesoate + 2 H(+) + NADH => (2E,6E)-farnesal + H2O + NAD(+)"}
{"X":27007,"RHEA_ID":44780,"DIRECTION":"UN","MASTER_ID":44780,"ec":"2.1.1.163","compounds":"2-demethylmenaquinol-9 + S-adenosyl-L-methionine = H(+) + menaquinol-9 + S-adenosyl-L-homocysteine"}
{"X":27008,"RHEA_ID":24220,"DIRECTION":"UN","MASTER_ID":24220,"ec":"1.14.14.31","compounds":"beta-myrcene + O2 + reduced [NADPH--hemoprotein reductase] = (4R)-ipsdienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":27009,"RHEA_ID":24221,"DIRECTION":"LR","MASTER_ID":24220,"metacyc":"RXN-15040","compounds":"beta-myrcene + O2 + reduced [NADPH--hemoprotein reductase] => (4R)-ipsdienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":27010,"RHEA_ID":24222,"compounds":"(4R)-ipsdienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => beta-myrcene + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":27011,"RHEA_ID":44784,"DIRECTION":"UN","MASTER_ID":44784,"ec":"2.1.1.163","compounds":"2-demethylmenaquinol-10 + S-adenosyl-L-methionine = H(+) + menaquinol-10 + S-adenosyl-L-homocysteine"}
{"X":27012,"RHEA_ID":24224,"DIRECTION":"UN","MASTER_ID":24224,"ec":"1.3.1.67","metacyc":"1.3.1.67-RXN","compounds":"(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NADP(+) = 4-methylcatechol + CO2 + NADPH"}
{"X":27013,"RHEA_ID":24225,"compounds":"(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NADP(+) => 4-methylcatechol + CO2 + NADPH"}
{"X":27014,"RHEA_ID":24226,"compounds":"4-methylcatechol + CO2 + NADPH => (1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NADP(+)"}
{"X":27015,"RHEA_ID":34860,"compounds":"3-oxocyclopentanecarbonitrile + 2 H2O => 3-oxocyclopentanecarboxylate + NH4(+)"}
{"X":27016,"RHEA_ID":24228,"DIRECTION":"UN","MASTER_ID":24228,"ec":"1.3.1.67","metacyc":"1.3.1.67-RXN","compounds":"(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NAD(+) = 4-methylcatechol + CO2 + NADH"}
{"X":27017,"RHEA_ID":24229,"compounds":"(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NAD(+) => 4-methylcatechol + CO2 + NADH"}
{"X":27018,"RHEA_ID":34863,"DIRECTION":"UN","MASTER_ID":34863,"ec":"4.2.1.17","compounds":"2,3-didehydroadipyl-CoA + H2O = 3-hydroxyadipyl-CoA"}
{"X":27019,"RHEA_ID":34864,"compounds":"2,3-didehydroadipyl-CoA + H2O => 3-hydroxyadipyl-CoA"}
{"X":27020,"RHEA_ID":24232,"DIRECTION":"UN","MASTER_ID":24232,"ec":"1.1.1.127","compounds":"2-dehydro-3-deoxy-D-gluconate + NAD(+) = 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH"}
{"X":27021,"RHEA_ID":24233,"compounds":"2-dehydro-3-deoxy-D-gluconate + NAD(+) => 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH"}
{"X":27022,"RHEA_ID":24234,"compounds":"3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH => 2-dehydro-3-deoxy-D-gluconate + NAD(+)"}
{"X":27023,"RHEA_ID":34868,"compounds":"ATP + CoA + thiophene-2-carboxylate => AMP + diphosphate + thiophene-2-carbonyl-CoA"}
{"X":27024,"RHEA_ID":24236,"DIRECTION":"UN","MASTER_ID":24236,"ec":"1.7.2.3","compounds":"2 [Fe(III)cytochrome c] + H2O + trimethylamine = 2 [Fe(II)cytochrome c] + 3 H(+) + trimethylamine N-oxide"}
{"X":27025,"RHEA_ID":24237,"compounds":"2 [Fe(III)cytochrome c] + H2O + trimethylamine => 2 [Fe(II)cytochrome c] + 3 H(+) + trimethylamine N-oxide"}
{"X":27026,"RHEA_ID":34871,"compounds":"methanol(out) = methanol(in)"}
{"X":27027,"RHEA_ID":24239,"compounds":"2 [Fe(III)cytochrome c] + H2O + trimethylamine <=> 2 [Fe(II)cytochrome c] + 3 H(+) + trimethylamine N-oxide"}
{"X":27028,"RHEA_ID":24240,"DIRECTION":"UN","MASTER_ID":24240,"ec":"1.8.99.2","compounds":"A + AMP + 2 H(+) + sulfite = adenosine 5'-phosphosulfate + AH2"}
{"X":27029,"RHEA_ID":24241,"compounds":"A + AMP + 2 H(+) + sulfite => adenosine 5'-phosphosulfate + AH2"}
{"X":27030,"RHEA_ID":34875,"compounds":"2-oxepin-2(3H)-ylideneacetyl-CoA + 2 H2O + NADP(+) = 3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH"}
{"X":27031,"RHEA_ID":34876,"DIRECTION":"LR","MASTER_ID":34875,"ecocyc":"RXN0-6511","metacyc":"RXN0-6511","compounds":"2-oxepin-2(3H)-ylideneacetyl-CoA + 2 H2O + NADP(+) => 3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH"}
{"X":27032,"RHEA_ID":24244,"DIRECTION":"UN","MASTER_ID":24244,"ec":"1.1.1.236","compounds":"NADP(+) + pseudotropine = H(+) + NADPH + tropinone"}
{"X":27033,"RHEA_ID":24245,"compounds":"NADP(+) + pseudotropine => H(+) + NADPH + tropinone"}
{"X":27034,"RHEA_ID":34879,"compounds":"2 H2O + methyl 3-cyano-2-phenylpropanoate = 4-methoxy-4-oxo-3-phenylbutanoate + NH4(+)"}
{"X":27035,"RHEA_ID":34880,"compounds":"2 H2O + methyl 3-cyano-2-phenylpropanoate => 4-methoxy-4-oxo-3-phenylbutanoate + NH4(+)"}
{"X":27036,"RHEA_ID":24248,"DIRECTION":"UN","MASTER_ID":24248,"ec":"2.6.1.44","compounds":"glyoxylate + L-alanine = glycine + pyruvate"}
{"X":27037,"RHEA_ID":24249,"DIRECTION":"LR","MASTER_ID":24248,"metacyc":"ALANINE--GLYOXYLATE-AMINOTRANSFERASE-RXN","reactome":"R-HSA-904864.3","compounds":"glyoxylate + L-alanine => glycine + pyruvate"}
{"X":27038,"RHEA_ID":34883,"compounds":"ATP + H2O + selenate(out) = ADP + H(+) + phosphate + selenate(in)"}
{"X":27039,"RHEA_ID":24250,"compounds":"glycine + pyruvate => glyoxylate + L-alanine"}
{"X":27040,"RHEA_ID":24252,"DIRECTION":"UN","MASTER_ID":24252,"ec":"3.6.1.41","compounds":"H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate = 2 ADP + 2 H(+)"}
{"X":27041,"RHEA_ID":24253,"DIRECTION":"LR","MASTER_ID":24252,"ecocyc":"3.6.1.41-RXN","metacyc":"3.6.1.41-RXN","compounds":"H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate => 2 ADP + 2 H(+)"}
{"X":27042,"RHEA_ID":24254,"compounds":"2 ADP + 2 H(+) => H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate"}
{"X":27043,"RHEA_ID":34889,"compounds":"selenate(out) => selenate(in)"}
{"X":27044,"RHEA_ID":24256,"DIRECTION":"UN","MASTER_ID":24256,"ec":"2.7.1.95","compounds":"ATP + kanamycin A = ADP + H(+) + kanamycin 3'-phosphate"}
{"X":27045,"RHEA_ID":24257,"compounds":"ATP + kanamycin A => ADP + H(+) + kanamycin 3'-phosphate"}
{"X":27046,"RHEA_ID":24258,"compounds":"ADP + H(+) + kanamycin 3'-phosphate => ATP + kanamycin A"}
{"X":27047,"RHEA_ID":34893,"compounds":"selenite(out) => selenite(in)"}
{"X":27048,"RHEA_ID":24260,"DIRECTION":"UN","MASTER_ID":24260,"ec":"4.1.1.77","compounds":"(3E)-2-oxohex-3-enedioate + H(+) = 2-oxopent-4-enoate + CO2"}
{"X":27049,"RHEA_ID":24261,"DIRECTION":"LR","MASTER_ID":24260,"metacyc":"4.1.1.77-RXN","compounds":"(3E)-2-oxohex-3-enedioate + H(+) => 2-oxopent-4-enoate + CO2"}
{"X":27050,"RHEA_ID":34896,"DIRECTION":"LR","MASTER_ID":34895,"ecocyc":"TRANS-RXN0-479","compounds":"ATP + H2O + selenite(out) => ADP + H(+) + phosphate + selenite(in)"}
{"X":27051,"RHEA_ID":34897,"compounds":"ADP + H(+) + phosphate + selenite(in) => ATP + H2O + selenite(out)"}
{"X":27052,"RHEA_ID":24264,"DIRECTION":"UN","MASTER_ID":24264,"ec":"2.2.1.3","compounds":"D-xylulose 5-phosphate + formaldehyde = D-glyceraldehyde 3-phosphate + dihydroxyacetone"}
{"X":27053,"RHEA_ID":24265,"DIRECTION":"LR","MASTER_ID":24264,"metacyc":"FORMALDEHYDE-TRANSKETOLASE-RXN","compounds":"D-xylulose 5-phosphate + formaldehyde => D-glyceraldehyde 3-phosphate + dihydroxyacetone"}
{"X":27054,"RHEA_ID":34900,"DIRECTION":"LR","MASTER_ID":34899,"ecocyc":"RXN-11475","metacyc":"RXN-11475","compounds":"malonyl-CoA + S-adenosyl-L-methionine => malonyl-CoA methyl ester + S-adenosyl-L-homocysteine"}
{"X":27055,"RHEA_ID":34901,"compounds":"malonyl-CoA methyl ester + S-adenosyl-L-homocysteine => malonyl-CoA + S-adenosyl-L-methionine"}
{"X":27056,"RHEA_ID":24268,"DIRECTION":"UN","MASTER_ID":24268,"ec":"1.3.1.40","metacyc":"1.3.1.40-RXN","compounds":"2,6-dioxo-6-phenylhexanoate + NADP(+) = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+) + NADPH"}
{"X":27057,"RHEA_ID":24269,"compounds":"2,6-dioxo-6-phenylhexanoate + NADP(+) => 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+) + NADPH"}
{"X":27058,"RHEA_ID":24270,"compounds":"2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+) + NADPH => 2,6-dioxo-6-phenylhexanoate + NADP(+)"}
{"X":27059,"RHEA_ID":34905,"compounds":"glutathione disulfide + 3 H2O + selenodiglutathione => 4 glutathione + 2 H(+) + selenite"}
{"X":27060,"RHEA_ID":24272,"compounds":"H(+) + Mg-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = H2O + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADP(+)"}
{"X":27061,"RHEA_ID":24273,"DIRECTION":"LR","MASTER_ID":24272,"metacyc":"RXN-5282","compounds":"H(+) + Mg-protoporphyrin IX 13-monomethyl ester + NADPH + O2 => H2O + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADP(+)"}
{"X":27062,"RHEA_ID":34908,"compounds":"molybdate(in) => molybdate(out)"}
{"X":27063,"RHEA_ID":34909,"compounds":"molybdate(out) => molybdate(in)"}
{"X":27064,"RHEA_ID":24276,"DIRECTION":"UN","MASTER_ID":24276,"ec":"2.7.2.12","metacyc":"ACETATE-KINASE-PYROPHOSPHATE-RXN","compounds":"acetate + diphosphate = acetyl phosphate + phosphate"}
{"X":27065,"RHEA_ID":24277,"compounds":"acetate + diphosphate => acetyl phosphate + phosphate"}
{"X":27066,"RHEA_ID":34912,"compounds":"D-methionine(in) => D-methionine(out)"}
{"X":27067,"RHEA_ID":24280,"compounds":"myricetin + 2 S-adenosyl-L-methionine = 2 H(+) + 2 S-adenosyl-L-homocysteine + syringetin"}
{"X":27068,"RHEA_ID":24281,"compounds":"myricetin + 2 S-adenosyl-L-methionine => 2 H(+) + 2 S-adenosyl-L-homocysteine + syringetin"}
{"X":27069,"RHEA_ID":34916,"compounds":"D-galactose(in) => D-galactose(out)"}
{"X":27070,"RHEA_ID":24283,"DIRECTION":"BI","MASTER_ID":24280,"metacyc":"2.1.1.149-RXN","compounds":"myricetin + 2 S-adenosyl-L-methionine <=> 2 H(+) + 2 S-adenosyl-L-homocysteine + syringetin"}
{"X":27071,"RHEA_ID":24284,"DIRECTION":"UN","MASTER_ID":24284,"ec":"1.2.1.11","compounds":"L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH"}
{"X":27072,"RHEA_ID":24285,"compounds":"L-aspartate 4-semialdehyde + NADP(+) + phosphate => 4-phospho-L-aspartate + H(+) + NADPH"}
{"X":27073,"RHEA_ID":34920,"DIRECTION":"LR","MASTER_ID":34919,"reactome":"R-HSA-199626.1","compounds":"thiamine(in) => thiamine(out)"}
{"X":27074,"RHEA_ID":34921,"compounds":"thiamine(out) => thiamine(in)"}
{"X":27075,"RHEA_ID":24288,"DIRECTION":"UN","MASTER_ID":24288,"ec":"2.1.2.4","compounds":"5-formimidoyltetrahydrofolate + glycine = (6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine"}
{"X":27076,"RHEA_ID":24289,"compounds":"5-formimidoyltetrahydrofolate + glycine => (6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine"}
{"X":27077,"RHEA_ID":34924,"DIRECTION":"LR","MASTER_ID":34923,"reactome":"R-HSA-432036.4","compounds":"nitrate(in) => nitrate(out)"}
{"X":27078,"RHEA_ID":34925,"compounds":"nitrate(out) => nitrate(in)"}
{"X":27079,"RHEA_ID":24292,"DIRECTION":"UN","MASTER_ID":24292,"ec":"2.3.1.1","compounds":"acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate"}
{"X":27080,"RHEA_ID":24293,"DIRECTION":"LR","MASTER_ID":24292,"reactome":"R-HSA-70542.4","compounds":"acetyl-CoA + L-glutamate => CoA + H(+) + N-acetyl-L-glutamate"}
{"X":27081,"RHEA_ID":34928,"DIRECTION":"LR","MASTER_ID":34927,"metacyc":"RXN-12865","reactome":"R-HSA-2408542.1","compounds":"H(+) + NADPH + selenodiglutathione => glutathione + glutathioselenol + NADP(+)"}
{"X":27082,"RHEA_ID":34929,"compounds":"glutathione + glutathioselenol + NADP(+) => H(+) + NADPH + selenodiglutathione"}
{"X":27083,"RHEA_ID":24296,"DIRECTION":"UN","MASTER_ID":24296,"ec":"3.5.2.3","compounds":"(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate"}
{"X":27084,"RHEA_ID":24297,"compounds":"(S)-dihydroorotate + H2O => H(+) + N-carbamoyl-L-aspartate"}
{"X":27085,"RHEA_ID":24298,"DIRECTION":"RL","MASTER_ID":24296,"reactome":"R-HSA-73571.2","compounds":"H(+) + N-carbamoyl-L-aspartate => (S)-dihydroorotate + H2O"}
{"X":27086,"RHEA_ID":34933,"compounds":"glutathione + hydrogenselenide + NADP(+) => glutathioselenol + NADPH"}
{"X":27087,"RHEA_ID":24300,"DIRECTION":"UN","MASTER_ID":24300,"ec":"1.16.8.1","compounds":"2 cob(I)yrinate a,c diamide + FMN + 3 H(+) = 2 cob(II)yrinate a,c diamide + FMNH2"}
{"X":27088,"RHEA_ID":24301,"compounds":"2 cob(I)yrinate a,c diamide + FMN + 3 H(+) => 2 cob(II)yrinate a,c diamide + FMNH2"}
{"X":27089,"RHEA_ID":24302,"DIRECTION":"RL","MASTER_ID":24300,"metacyc":"R343-RXN","compounds":"2 cob(II)yrinate a,c diamide + FMNH2 => 2 cob(I)yrinate a,c diamide + FMN + 3 H(+)"}
{"X":27090,"RHEA_ID":34937,"compounds":"diphosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate => 2 ATP + H(+)"}
{"X":27091,"RHEA_ID":24304,"DIRECTION":"UN","MASTER_ID":24304,"ec":"1.4.4.2","compounds":"glycine + H(+) + N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2"}
{"X":27092,"RHEA_ID":24305,"compounds":"glycine + H(+) + N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] => (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2"}
{"X":27093,"RHEA_ID":34940,"compounds":"H2O + menaquinone-8 + selenite => menaquinol-8 + selenate"}
{"X":27094,"RHEA_ID":24308,"DIRECTION":"UN","MASTER_ID":24308,"ec":"1.14.14.29","compounds":"25-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":27095,"RHEA_ID":24309,"DIRECTION":"LR","MASTER_ID":24308,"metacyc":"RXN-7980","compounds":"25-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 7alpha,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":27096,"RHEA_ID":34944,"DIRECTION":"LR","MASTER_ID":34943,"ecocyc":"TRANS-RXN-153","compounds":"hydroquinone O-beta-D-glucopyranoside(out) + phosphoenolpyruvate(in) => arbutin 6-phosphate(in) + pyruvate(in)"}
{"X":27097,"RHEA_ID":34945,"compounds":"arbutin 6-phosphate(in) + pyruvate(in) => hydroquinone O-beta-D-glucopyranoside(out) + phosphoenolpyruvate(in)"}
{"X":27098,"RHEA_ID":24312,"DIRECTION":"UN","MASTER_ID":24312,"ec":"2.1.1.59","compounds":"L-lysyl-[cytochrome c] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[cytochrome c] + S-adenosyl-L-homocysteine"}
{"X":27099,"RHEA_ID":24313,"DIRECTION":"LR","MASTER_ID":24312,"metacyc":"2.1.1.59-RXN","compounds":"L-lysyl-[cytochrome c] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl-[cytochrome c] + S-adenosyl-L-homocysteine"}
{"X":27100,"RHEA_ID":24314,"compounds":"H(+) + N(6)-methyl-L-lysyl-[cytochrome c] + S-adenosyl-L-homocysteine => L-lysyl-[cytochrome c] + S-adenosyl-L-methionine"}
{"X":27101,"RHEA_ID":34949,"compounds":"3-oxopropanoate + NH4(+) => (Z)-3-aminoacrylate + H(+) + H2O"}
{"X":27102,"RHEA_ID":24316,"DIRECTION":"UN","MASTER_ID":24316,"ec":"5.5.1.12","compounds":"all-trans-geranylgeranyl diphosphate = (+)-copalyl diphosphate"}
{"X":27103,"RHEA_ID":24317,"DIRECTION":"LR","MASTER_ID":24316,"metacyc":"RXN-4861","compounds":"all-trans-geranylgeranyl diphosphate => (+)-copalyl diphosphate"}
{"X":27104,"RHEA_ID":24318,"compounds":"(+)-copalyl diphosphate => all-trans-geranylgeranyl diphosphate"}
{"X":27105,"RHEA_ID":34953,"compounds":"3-hydroxypropanoate(in) => 3-hydroxypropanoate(out)"}
{"X":27106,"RHEA_ID":24320,"compounds":"an L-polyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = an L-N-hydroxypolyhomomethionine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":27107,"RHEA_ID":24321,"DIRECTION":"LR","MASTER_ID":24320,"metacyc":"RXN-18172","compounds":"an L-polyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => an L-N-hydroxypolyhomomethionine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":27108,"RHEA_ID":34956,"DIRECTION":"LR","MASTER_ID":34955,"ecocyc":"TRANS-RXN0-461","compounds":"S-methyl-5-thio-D-ribose(in) => S-methyl-5-thio-D-ribose(out)"}
{"X":27109,"RHEA_ID":24324,"DIRECTION":"UN","MASTER_ID":24324,"ec":"1.14.13.51","compounds":"6-oxocineole + H(+) + NADPH + O2 = 1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + H2O + NADP(+)"}
{"X":27110,"RHEA_ID":24325,"DIRECTION":"LR","MASTER_ID":24324,"metacyc":"6-OXOCINEOLE-DEHYDROGENASE-RXN","compounds":"6-oxocineole + H(+) + NADPH + O2 => 1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + H2O + NADP(+)"}
{"X":27111,"RHEA_ID":34960,"compounds":"(R)-carnitine(in) => (R)-carnitine(out)"}
{"X":27112,"RHEA_ID":34961,"compounds":"(R)-carnitine(out) => (R)-carnitine(in)"}
{"X":27113,"RHEA_ID":24328,"DIRECTION":"UN","MASTER_ID":24328,"ec":"6.3.4.17","compounds":"7,8-dihydrofolate + ATP + formate = 10-formyldihydrofolate + ADP + phosphate"}
{"X":27114,"RHEA_ID":24329,"DIRECTION":"LR","MASTER_ID":24328,"metacyc":"FORMATE--DIHYDROFOLATE-LIGASE-RXN","compounds":"7,8-dihydrofolate + ATP + formate => 10-formyldihydrofolate + ADP + phosphate"}
{"X":27115,"RHEA_ID":34964,"DIRECTION":"LR","MASTER_ID":34963,"reactome":"R-HSA-438037.3","compounds":"Na(+)(in) => Na(+)(out)"}
{"X":27116,"RHEA_ID":34964,"DIRECTION":"LR","MASTER_ID":34963,"reactome":"R-HSA-399711.2","compounds":"Na(+)(in) => Na(+)(out)"}
{"X":27117,"RHEA_ID":24332,"compounds":"3alpha-hydroxy-3,5-dihydromonacolin L carboxylate = H2O + monacolin L carboxylate"}
{"X":27118,"RHEA_ID":24333,"DIRECTION":"LR","MASTER_ID":24332,"metacyc":"RXN-15672","compounds":"3alpha-hydroxy-3,5-dihydromonacolin L carboxylate => H2O + monacolin L carboxylate"}
{"X":27119,"RHEA_ID":34964,"DIRECTION":"LR","MASTER_ID":34963,"reactome":"R-HSA-3295580.1","compounds":"Na(+)(in) => Na(+)(out)"}
{"X":27120,"RHEA_ID":34964,"DIRECTION":"LR","MASTER_ID":34963,"reactome":"R-HSA-426223.1","compounds":"Na(+)(in) => Na(+)(out)"}
{"X":27121,"RHEA_ID":24336,"compounds":"a carboxylate + ATP + CoA = AMP + an acyl-CoA + diphosphate"}
{"X":27122,"RHEA_ID":24337,"DIRECTION":"LR","MASTER_ID":24336,"metacyc":"BUTYRATE--COA-LIGASE-RXN","compounds":"a carboxylate + ATP + CoA => AMP + an acyl-CoA + diphosphate"}
{"X":27123,"RHEA_ID":34964,"DIRECTION":"LR","MASTER_ID":34963,"reactome":"R-HSA-420980.2","compounds":"Na(+)(in) => Na(+)(out)"}
{"X":27124,"RHEA_ID":34964,"DIRECTION":"LR","MASTER_ID":34963,"reactome":"R-HSA-2672334.2","compounds":"Na(+)(in) => Na(+)(out)"}
{"X":27125,"RHEA_ID":24340,"DIRECTION":"UN","MASTER_ID":24340,"ec":"1.1.1.4","compounds":"(R,R)-butane-2,3-diol + NAD(+) = (R)-acetoin + H(+) + NADH"}
{"X":27126,"RHEA_ID":24341,"compounds":"(R,R)-butane-2,3-diol + NAD(+) => (R)-acetoin + H(+) + NADH"}
{"X":27127,"RHEA_ID":34967,"compounds":"sn-glycerol 3-phosphate(in) = sn-glycerol 3-phosphate(out)"}
{"X":27128,"RHEA_ID":24352,"DIRECTION":"UN","MASTER_ID":24352,"ec":"1.1.1.279","metacyc":"1.2.1.55-RXN","compounds":"ethyl (R)-3-hydroxyhexanoate + NADP(+) = ethyl 3-oxohexanoate + H(+) + NADPH"}
{"X":27129,"RHEA_ID":24353,"compounds":"ethyl (R)-3-hydroxyhexanoate + NADP(+) => ethyl 3-oxohexanoate + H(+) + NADPH"}
{"X":27130,"RHEA_ID":34971,"compounds":"Fe(3+)(in) = Fe(3+)(out)"}
{"X":27131,"RHEA_ID":34972,"compounds":"Fe(3+)(in) => Fe(3+)(out)"}
{"X":27132,"RHEA_ID":24356,"DIRECTION":"UN","MASTER_ID":24356,"ec":"5.4.1.1","metacyc":"LYSOLECITHIN-ACYLMUTASE-RXN","compounds":"a 1-acyl-sn-glycero-3-phosphocholine = a 2-acyl-sn-glycero-3-phosphocholine"}
{"X":27133,"RHEA_ID":24357,"compounds":"a 1-acyl-sn-glycero-3-phosphocholine => a 2-acyl-sn-glycero-3-phosphocholine"}
{"X":27134,"RHEA_ID":34975,"compounds":"(R)-pantothenate(in) = (R)-pantothenate(out)"}
{"X":27135,"RHEA_ID":24360,"DIRECTION":"UN","MASTER_ID":24360,"ec":"4.99.1.4","compounds":"2 H(+) + siroheme = Fe(2+) + sirohydrochlorin"}
{"X":27136,"RHEA_ID":24361,"DIRECTION":"LR","MASTER_ID":24360,"ecocyc":"SIROHEME-FERROCHELAT-RXN","metacyc":"SIROHEME-FERROCHELAT-RXN","compounds":"2 H(+) + siroheme => Fe(2+) + sirohydrochlorin"}
{"X":27137,"RHEA_ID":34979,"compounds":"H(+)(in) = H(+)(out)"}
{"X":27138,"RHEA_ID":34980,"DIRECTION":"LR","MASTER_ID":34979,"reactome":"R-HSA-1222516.1","compounds":"H(+)(in) => H(+)(out)"}
{"X":27139,"RHEA_ID":24364,"compounds":"H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + NAD(+) = 2''-O-(2-hydroxyisobutanoyl)-ADP-D-ribose + L-lysyl-[protein] + nicotinamide"}
{"X":27140,"RHEA_ID":24365,"compounds":"H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + NAD(+) => 2''-O-(2-hydroxyisobutanoyl)-ADP-D-ribose + L-lysyl-[protein] + nicotinamide"}
{"X":27141,"RHEA_ID":34981,"DIRECTION":"RL","MASTER_ID":34979,"reactome":"R-HSA-74723.2","compounds":"H(+)(out) => H(+)(in)"}
{"X":27142,"RHEA_ID":24367,"compounds":"H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + NAD(+) <=> 2''-O-(2-hydroxyisobutanoyl)-ADP-D-ribose + L-lysyl-[protein] + nicotinamide"}
{"X":27143,"RHEA_ID":24368,"DIRECTION":"UN","MASTER_ID":24368,"ec":"4.3.1.12","compounds":"L-ornithine = L-proline + NH4(+)"}
{"X":27144,"RHEA_ID":24369,"DIRECTION":"LR","MASTER_ID":24368,"metacyc":"ORNITHINE-CYCLODEAMINASE-RXN","compounds":"L-ornithine => L-proline + NH4(+)"}
{"X":27145,"RHEA_ID":34985,"compounds":"sulfate(out) => sulfate(in)"}
{"X":27146,"RHEA_ID":34986,"compounds":"sulfate(in) <=> sulfate(out)"}
{"X":27147,"RHEA_ID":24372,"DIRECTION":"UN","MASTER_ID":24372,"ec":"3.1.4.45","compounds":"H2O + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] = H(+) + N(4)-[6-phospho-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + N-acetyl-D-glucosamine"}
{"X":27148,"RHEA_ID":24373,"compounds":"H2O + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] => H(+) + N(4)-[6-phospho-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + N-acetyl-D-glucosamine"}
{"X":27149,"RHEA_ID":24374,"compounds":"H(+) + N(4)-[6-phospho-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + N-acetyl-D-glucosamine => H2O + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein]"}
{"X":27150,"RHEA_ID":24376,"DIRECTION":"UN","MASTER_ID":24376,"ec":"6.3.4.11","compounds":"apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin = AMP + diphosphate + H(+) + holo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]"}
{"X":27151,"RHEA_ID":24377,"compounds":"apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin => AMP + diphosphate + H(+) + holo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]"}
{"X":27152,"RHEA_ID":34993,"compounds":"L-arginine(in) + L-ornithine(out) => L-arginine(out) + L-ornithine(in)"}
{"X":27153,"RHEA_ID":34994,"compounds":"L-arginine(out) + L-ornithine(in) <=> L-arginine(in) + L-ornithine(out)"}
{"X":27154,"RHEA_ID":24380,"DIRECTION":"UN","MASTER_ID":24380,"ec":"2.1.2.9","compounds":"(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)"}
{"X":27155,"RHEA_ID":24381,"DIRECTION":"LR","MASTER_ID":24380,"ecocyc":"METHIONYL-TRNA-FORMYLTRANSFERASE-RXN","metacyc":"METHIONYL-TRNA-FORMYLTRANSFERASE-RXN","compounds":"(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) => (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)"}
{"X":27156,"RHEA_ID":34997,"compounds":"L-rhamnose(out) => L-rhamnose(in)"}
{"X":27157,"RHEA_ID":34998,"compounds":"L-rhamnose(in) <=> L-rhamnose(out)"}
{"X":27158,"RHEA_ID":24384,"DIRECTION":"UN","MASTER_ID":24384,"ec":"6.3.5.1","compounds":"ATP + deamido-NAD(+) + H2O + L-glutamine = AMP + diphosphate + H(+) + L-glutamate + NAD(+)"}
{"X":27159,"RHEA_ID":24385,"DIRECTION":"LR","MASTER_ID":24384,"ecocyc":"NAD-SYNTH-GLN-RXN","metacyc":"NAD-SYNTH-GLN-RXN","reactome":"R-HSA-197271.2","compounds":"ATP + deamido-NAD(+) + H2O + L-glutamine => AMP + diphosphate + H(+) + L-glutamate + NAD(+)"}
{"X":27160,"RHEA_ID":35000,"DIRECTION":"LR","MASTER_ID":34999,"reactome":"R-HSA-163215.2","compounds":"ADP(in) + ATP(out) => ADP(out) + ATP(in)"}
{"X":27161,"RHEA_ID":35001,"compounds":"ADP(out) + ATP(in) => ADP(in) + ATP(out)"}
{"X":27162,"RHEA_ID":24388,"DIRECTION":"UN","MASTER_ID":24388,"ec":"2.4.2.2","compounds":"phosphate + uridine = alpha-D-ribose 1-phosphate + uracil"}
{"X":27163,"RHEA_ID":24388,"DIRECTION":"UN","MASTER_ID":24388,"ec":"2.4.2.3","compounds":"phosphate + uridine = alpha-D-ribose 1-phosphate + uracil"}
{"X":27164,"RHEA_ID":35004,"compounds":"L-fucose(in) => L-fucose(out)"}
{"X":27165,"RHEA_ID":24390,"compounds":"alpha-D-ribose 1-phosphate + uracil => phosphate + uridine"}
{"X":27166,"RHEA_ID":35006,"compounds":"L-fucose(in) <=> L-fucose(out)"}
{"X":27167,"RHEA_ID":24392,"DIRECTION":"UN","MASTER_ID":24392,"ec":"2.4.2.27","compounds":"dTDP-L-dihydrostreptose + streptidine 6-phosphate = dTDP + H(+) + O-(1->4)-alpha-L-dihydrostreptosyl-streptidine 6-phosphate"}
{"X":27168,"RHEA_ID":35008,"compounds":"D-fucose(in) => D-fucose(out)"}
{"X":27169,"RHEA_ID":24394,"compounds":"dTDP + H(+) + O-(1->4)-alpha-L-dihydrostreptosyl-streptidine 6-phosphate => dTDP-L-dihydrostreptose + streptidine 6-phosphate"}
{"X":27170,"RHEA_ID":35010,"compounds":"D-fucose(in) <=> D-fucose(out)"}
{"X":27171,"RHEA_ID":24396,"DIRECTION":"UN","MASTER_ID":24396,"ec":"4.2.1.94","compounds":"scytalone = 1,3,8-trihydroxynaphthalene + H2O"}
{"X":27172,"RHEA_ID":24397,"compounds":"scytalone => 1,3,8-trihydroxynaphthalene + H2O"}
{"X":27173,"RHEA_ID":24398,"compounds":"1,3,8-trihydroxynaphthalene + H2O => scytalone"}
{"X":27174,"RHEA_ID":35014,"compounds":"D-fucose(in) + H(+)(in) <=> D-fucose(out) + H(+)(out)"}
{"X":27175,"RHEA_ID":24400,"DIRECTION":"UN","MASTER_ID":24400,"ec":"2.7.4.22","compounds":"ATP + UMP = ADP + UDP"}
{"X":27176,"RHEA_ID":24400,"DIRECTION":"UN","MASTER_ID":24400,"ec":"2.7.4.14","compounds":"ATP + UMP = ADP + UDP"}
{"X":27177,"RHEA_ID":24401,"DIRECTION":"LR","MASTER_ID":24400,"ecocyc":"RXN-12002","metacyc":"RXN-12002","compounds":"ATP + UMP => ADP + UDP"}
{"X":27178,"RHEA_ID":24402,"compounds":"ADP + UDP => ATP + UMP"}
{"X":27179,"RHEA_ID":35019,"compounds":"L-threonine(in) = L-threonine(out)"}
{"X":27180,"RHEA_ID":35020,"compounds":"L-threonine(in) => L-threonine(out)"}
{"X":27181,"RHEA_ID":24405,"DIRECTION":"LR","MASTER_ID":24404,"metacyc":"HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN","reactome":"R-HSA-74180.2","compounds":"(3S)-hydroxy-3-methylglutaryl-CoA => acetoacetate + acetyl-CoA"}
{"X":27182,"RHEA_ID":24405,"DIRECTION":"LR","MASTER_ID":24404,"metacyc":"HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN","reactome":"R-HSA-6788597.1","compounds":"(3S)-hydroxy-3-methylglutaryl-CoA => acetoacetate + acetyl-CoA"}
{"X":27183,"RHEA_ID":24406,"compounds":"acetoacetate + acetyl-CoA => (3S)-hydroxy-3-methylglutaryl-CoA"}
{"X":27184,"RHEA_ID":35024,"compounds":"hydroquinone O-beta-D-glucopyranoside(out) => hydroquinone O-beta-D-glucopyranoside(in)"}
{"X":27185,"RHEA_ID":24408,"DIRECTION":"UN","MASTER_ID":24408,"ec":"3.5.4.4","compounds":"adenosine + H(+) + H2O = inosine + NH4(+)"}
{"X":27186,"RHEA_ID":24409,"DIRECTION":"LR","MASTER_ID":24408,"reactome":"R-HSA-5693346.1","compounds":"adenosine + H(+) + H2O => inosine + NH4(+)"}
{"X":27187,"RHEA_ID":24409,"DIRECTION":"LR","MASTER_ID":24408,"reactome":"R-HSA-74241.4","compounds":"adenosine + H(+) + H2O => inosine + NH4(+)"}
{"X":27188,"RHEA_ID":35028,"DIRECTION":"LR","MASTER_ID":35027,"metacyc":"TRANS-RXN-242","compounds":"ATP + H2O + tungstate(in) => ADP + H(+) + phosphate + tungstate(out)"}
{"X":27189,"RHEA_ID":35029,"compounds":"ADP + H(+) + phosphate + tungstate(out) => ATP + H2O + tungstate(in)"}
{"X":27190,"RHEA_ID":24412,"DIRECTION":"UN","MASTER_ID":24412,"ec":"1.1.1.257","compounds":"4-(hydroxymethyl)benzenesulfonate + NAD(+) = 4-formylbenzenesulfonate + H(+) + NADH"}
{"X":27191,"RHEA_ID":24413,"compounds":"4-(hydroxymethyl)benzenesulfonate + NAD(+) => 4-formylbenzenesulfonate + H(+) + NADH"}
{"X":27192,"RHEA_ID":35032,"DIRECTION":"LR","MASTER_ID":35031,"reactome":"R-HSA-376200.1","compounds":"L-serine(in) => L-serine(out)"}
{"X":27193,"RHEA_ID":35033,"DIRECTION":"RL","MASTER_ID":35031,"reactome":"R-HSA-8932980.1","compounds":"L-serine(out) => L-serine(in)"}
{"X":27194,"RHEA_ID":24416,"DIRECTION":"UN","MASTER_ID":24416,"ec":"1.13.11.41","compounds":"2,4'-dihydroxyacetophenone + O2 = 4-hydroxybenzoate + formate + 2 H(+)"}
{"X":27195,"RHEA_ID":24417,"DIRECTION":"LR","MASTER_ID":24416,"metacyc":"1.13.11.41-RXN","compounds":"2,4'-dihydroxyacetophenone + O2 => 4-hydroxybenzoate + formate + 2 H(+)"}
{"X":27196,"RHEA_ID":35036,"DIRECTION":"LR","MASTER_ID":35035,"reactome":"R-HSA-9653180.1","compounds":"4-aminobutanoate(in) => 4-aminobutanoate(out)"}
{"X":27197,"RHEA_ID":35037,"compounds":"4-aminobutanoate(out) => 4-aminobutanoate(in)"}
{"X":27198,"RHEA_ID":24420,"DIRECTION":"UN","MASTER_ID":24420,"ec":"3.5.1.88","compounds":"H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]"}
{"X":27199,"RHEA_ID":24421,"DIRECTION":"LR","MASTER_ID":24420,"ecocyc":"3.5.1.88-RXN","metacyc":"3.5.1.88-RXN","compounds":"H2O + N-terminal N-formyl-L-methionyl-[peptide] => formate + N-terminal L-methionyl-[peptide]"}
{"X":27200,"RHEA_ID":35040,"DIRECTION":"LR","MASTER_ID":35039,"reactome":"R-HSA-549129.1","compounds":"spermidine(in) => spermidine(out)"}
{"X":27201,"RHEA_ID":24424,"DIRECTION":"UN","MASTER_ID":24424,"ec":"1.8.5.1","compounds":"2 glutathione + L-dehydroascorbate = glutathione disulfide + L-ascorbate"}
{"X":27202,"RHEA_ID":24425,"DIRECTION":"LR","MASTER_ID":24424,"metacyc":"1.8.5.1-RXN","reactome":"R-HSA-198813.3","compounds":"2 glutathione + L-dehydroascorbate => glutathione disulfide + L-ascorbate"}
{"X":27203,"RHEA_ID":35044,"compounds":"N-(4-aminobenzoyl)-L-glutamate(in) => N-(4-aminobenzoyl)-L-glutamate(out)"}
{"X":27204,"RHEA_ID":35045,"compounds":"N-(4-aminobenzoyl)-L-glutamate(out) => N-(4-aminobenzoyl)-L-glutamate(in)"}
{"X":27205,"RHEA_ID":24432,"DIRECTION":"UN","MASTER_ID":24432,"ec":"3.7.1.1","compounds":"H2O + oxaloacetate = acetate + H(+) + oxalate"}
{"X":27206,"RHEA_ID":24433,"DIRECTION":"LR","MASTER_ID":24432,"metacyc":"OXALOACETASE-RXN","compounds":"H2O + oxaloacetate => acetate + H(+) + oxalate"}
{"X":27207,"RHEA_ID":35048,"DIRECTION":"LR","MASTER_ID":35047,"ecocyc":"RXN-8348","metacyc":"RXN-8348","compounds":"adenylyl-molybdopterin + H(+) + molybdate => AMP + H2O + Mo-molybdopterin"}
{"X":27208,"RHEA_ID":24436,"DIRECTION":"UN","MASTER_ID":24436,"ec":"1.12.98.3","compounds":"H2 + methanophenazine = dihydromethanophenazine"}
{"X":27209,"RHEA_ID":24437,"DIRECTION":"LR","MASTER_ID":24436,"metacyc":"RXN-7733","compounds":"H2 + methanophenazine => dihydromethanophenazine"}
{"X":27210,"RHEA_ID":24438,"compounds":"dihydromethanophenazine => H2 + methanophenazine"}
{"X":27211,"RHEA_ID":35053,"compounds":"N,N'-diacetylchitobiose(in) => N,N'-diacetylchitobiose(out)"}
{"X":27212,"RHEA_ID":24440,"DIRECTION":"UN","MASTER_ID":24440,"ec":"7.3.2.1","compounds":"ATP + H2O + phosphate(out) = ADP + H(+) + 2 phosphate(in)"}
{"X":27213,"RHEA_ID":24441,"DIRECTION":"LR","MASTER_ID":24440,"ecocyc":"3.6.3.27-RXN","metacyc":"3.6.3.27-RXN","compounds":"ATP + H2O + phosphate(out) => ADP + H(+) + 2 phosphate(in)"}
{"X":27214,"RHEA_ID":35056,"compounds":"3,6-dichlorocatechol + O2 => (2E,4E)-2,5-dichloromuconate + H(+)"}
{"X":27215,"RHEA_ID":24442,"compounds":"ADP + H(+) + 2 phosphate(in) => ATP + H2O + phosphate(out)"}
{"X":27216,"RHEA_ID":24443,"compounds":"ATP + H2O + phosphate(out) <=> ADP + H(+) + 2 phosphate(in)"}
{"X":27217,"RHEA_ID":24444,"DIRECTION":"UN","MASTER_ID":24444,"ec":"2.4.1.214","compounds":"GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[(1->4)-alpha-L-Fuc]-beta-D-GlcNAc}-L-asparaginyl-[protein]"}
{"X":27218,"RHEA_ID":35060,"compounds":"chloramphenicol(in) + H(+)(out) => chloramphenicol(out) + H(+)(in)"}
{"X":27219,"RHEA_ID":24446,"compounds":"GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[(1->4)-alpha-L-Fuc]-beta-D-GlcNAc}-L-asparaginyl-[protein] => GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]"}
{"X":27220,"RHEA_ID":24448,"DIRECTION":"UN","MASTER_ID":24448,"ec":"2.4.1.369","compounds":"enterobactin + UDP-alpha-D-glucose = monoglucosyl-enterobactin + UDP"}
{"X":27221,"RHEA_ID":24449,"DIRECTION":"LR","MASTER_ID":24448,"metacyc":"RXN-20004","compounds":"enterobactin + UDP-alpha-D-glucose => monoglucosyl-enterobactin + UDP"}
{"X":27222,"RHEA_ID":24450,"compounds":"monoglucosyl-enterobactin + UDP => enterobactin + UDP-alpha-D-glucose"}
{"X":27223,"RHEA_ID":35066,"compounds":"H2O + pyrazinamide <=> NH4(+) + pyrazine-2-carboxylate"}
{"X":27224,"RHEA_ID":24452,"DIRECTION":"UN","MASTER_ID":24452,"ec":"2.1.1.80","compounds":"L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine"}
{"X":27225,"RHEA_ID":35068,"compounds":"(S)-carnitine(out) => (S)-carnitine(in)"}
{"X":27226,"RHEA_ID":24454,"compounds":"[protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine => L-glutamyl-[protein] + S-adenosyl-L-methionine"}
{"X":27227,"RHEA_ID":35070,"compounds":"(S)-carnitine(out) <=> (S)-carnitine(in)"}
{"X":27228,"RHEA_ID":24456,"DIRECTION":"UN","MASTER_ID":24456,"ec":"3.1.3.73","compounds":"alpha-ribazole 5'-phosphate + H2O = alpha-ribazole + phosphate"}
{"X":27229,"RHEA_ID":24457,"DIRECTION":"LR","MASTER_ID":24456,"ecocyc":"RIBAZOLEPHOSPHAT-RXN","metacyc":"RIBAZOLEPHOSPHAT-RXN","compounds":"alpha-ribazole 5'-phosphate + H2O => alpha-ribazole + phosphate"}
{"X":27230,"RHEA_ID":24458,"compounds":"alpha-ribazole + phosphate => alpha-ribazole 5'-phosphate + H2O"}
{"X":27231,"RHEA_ID":35074,"compounds":"4-methylphenol(in) <=> 4-methylphenol(out)"}
{"X":27232,"RHEA_ID":24460,"DIRECTION":"UN","MASTER_ID":24460,"ec":"4.1.1.87","compounds":"H(+) + malonyl-[ACP] = acetyl-[ACP] + CO2"}
{"X":27233,"RHEA_ID":24461,"DIRECTION":"LR","MASTER_ID":24460,"metacyc":"RXN-9730","compounds":"H(+) + malonyl-[ACP] => acetyl-[ACP] + CO2"}
{"X":27234,"RHEA_ID":24462,"compounds":"acetyl-[ACP] + CO2 => H(+) + malonyl-[ACP]"}
{"X":27235,"RHEA_ID":35079,"compounds":"doxorubicin(in) = doxorubicin(out)"}
{"X":27236,"RHEA_ID":24464,"DIRECTION":"UN","MASTER_ID":24464,"ec":"4.1.2.21","compounds":"2-dehydro-3-deoxy-6-phospho-D-galactonate = D-glyceraldehyde 3-phosphate + pyruvate"}
{"X":27237,"RHEA_ID":24465,"compounds":"2-dehydro-3-deoxy-6-phospho-D-galactonate => D-glyceraldehyde 3-phosphate + pyruvate"}
{"X":27238,"RHEA_ID":24466,"compounds":"D-glyceraldehyde 3-phosphate + pyruvate => 2-dehydro-3-deoxy-6-phospho-D-galactonate"}
{"X":27239,"RHEA_ID":35083,"compounds":"diacetylchitobiose-6'-phosphate + H2O = acetate + N'-monoacetylchitobiose-6'-phosphate"}
{"X":27240,"RHEA_ID":24468,"DIRECTION":"UN","MASTER_ID":24468,"ec":"1.14.13.8","compounds":"H(+) + N,N-dimethylaniline + NADPH + O2 = H2O + N,N-dimethylaniline N-oxide + NADP(+)"}
{"X":27241,"RHEA_ID":24469,"DIRECTION":"LR","MASTER_ID":24468,"metacyc":"1.14.13.8-RXN","compounds":"H(+) + N,N-dimethylaniline + NADPH + O2 => H2O + N,N-dimethylaniline N-oxide + NADP(+)"}
{"X":27242,"RHEA_ID":24470,"compounds":"H2O + N,N-dimethylaniline N-oxide + NADP(+) => H(+) + N,N-dimethylaniline + NADPH + O2"}
{"X":27243,"RHEA_ID":45032,"DIRECTION":"UN","MASTER_ID":45032,"ec":"1.7.2.6","compounds":"4 [Fe(III)cytochrome c] + H2O + hydroxylamine = 4 [Fe(II)cytochrome c] + 5 H(+) + nitrite"}
{"X":27244,"RHEA_ID":24472,"DIRECTION":"UN","MASTER_ID":24472,"ec":"1.16.1.3","compounds":"2 cob(II)alamin + H(+) + 2 H2O + NAD(+) = 2 aquacob(III)alamin + NADH"}
{"X":27245,"RHEA_ID":24473,"compounds":"2 cob(II)alamin + H(+) + 2 H2O + NAD(+) => 2 aquacob(III)alamin + NADH"}
{"X":27246,"RHEA_ID":24474,"compounds":"2 aquacob(III)alamin + NADH => 2 cob(II)alamin + H(+) + 2 H2O + NAD(+)"}
{"X":27247,"RHEA_ID":35091,"DIRECTION":"UN","MASTER_ID":35091,"ec":"6.3.2.40","compounds":"anthranilate + 2 ATP + L-phenylalanine + S-adenosyl-L-methionine = 2 AMP + cyclopeptine + 2 diphosphate + 2 H(+) + S-adenosyl-L-homocysteine"}
{"X":27248,"RHEA_ID":24476,"DIRECTION":"UN","MASTER_ID":24476,"ec":"3.5.2.16","metacyc":"3.5.2.16-RXN","compounds":"H2O + maleimide = H(+) + maleamate"}
{"X":27249,"RHEA_ID":24477,"compounds":"H2O + maleimide => H(+) + maleamate"}
{"X":27250,"RHEA_ID":24478,"compounds":"H(+) + maleamate => H2O + maleimide"}
{"X":27251,"RHEA_ID":24480,"DIRECTION":"UN","MASTER_ID":24480,"ec":"3.2.1.149","compounds":"a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O = a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol"}
{"X":27252,"RHEA_ID":24481,"DIRECTION":"LR","MASTER_ID":24480,"metacyc":"3.2.1.149-RXN","compounds":"a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O => a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol"}
{"X":27253,"RHEA_ID":24482,"compounds":"a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol => a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O"}
{"X":27254,"RHEA_ID":35099,"compounds":"fusidate(in) + H(+)(out) = fusidate(out) + H(+)(in)"}
{"X":27255,"RHEA_ID":24484,"DIRECTION":"UN","MASTER_ID":24484,"ec":"1.1.1.260","metacyc":"1.1.1.260-RXN","compounds":"NAD(+) + sulcatol = H(+) + NADH + sulcatone"}
{"X":27256,"RHEA_ID":24485,"compounds":"NAD(+) + sulcatol => H(+) + NADH + sulcatone"}
{"X":27257,"RHEA_ID":24486,"compounds":"H(+) + NADH + sulcatone => NAD(+) + sulcatol"}
{"X":27258,"RHEA_ID":45048,"DIRECTION":"UN","MASTER_ID":45048,"ec":"3.5.1.4","compounds":"acetamide + H2O = acetate + NH4(+)"}
{"X":27259,"RHEA_ID":24488,"DIRECTION":"UN","MASTER_ID":24488,"ec":"1.17.7.4","compounds":"H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":27260,"RHEA_ID":24489,"compounds":"H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] => (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":27261,"RHEA_ID":24490,"DIRECTION":"RL","MASTER_ID":24488,"ecocyc":"ISPH2-RXN","metacyc":"ISPH2-RXN","compounds":"(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":27262,"RHEA_ID":45052,"compounds":"(2E)-butenoyl-CoA + (R)-carnitine = CoA + O-(2E)-butenoyl-(R)-carnitine"}
{"X":27263,"RHEA_ID":24496,"DIRECTION":"UN","MASTER_ID":24496,"ec":"2.3.1.107","compounds":"4-O-deacetylvindoline + acetyl-CoA = CoA + vindoline"}
{"X":27264,"RHEA_ID":24497,"DIRECTION":"LR","MASTER_ID":24496,"metacyc":"2.3.1.107-RXN","compounds":"4-O-deacetylvindoline + acetyl-CoA => CoA + vindoline"}
{"X":27265,"RHEA_ID":24498,"compounds":"CoA + vindoline => 4-O-deacetylvindoline + acetyl-CoA"}
{"X":27266,"RHEA_ID":35111,"DIRECTION":"UN","MASTER_ID":35111,"ec":"1.1.1.346","compounds":"2-dehydro-L-idonate + NADP(+) = 2,5-didehydro-D-gluconate + H(+) + NADPH"}
{"X":27267,"RHEA_ID":35112,"compounds":"2-dehydro-L-idonate + NADP(+) => 2,5-didehydro-D-gluconate + H(+) + NADPH"}
{"X":27268,"RHEA_ID":24501,"DIRECTION":"LR","MASTER_ID":24500,"metacyc":"ADENOSINE-TETRAPHOSPHATASE-RXN","compounds":"adenosine 5'-tetraphosphate + H2O => ATP + H(+) + phosphate"}
{"X":27269,"RHEA_ID":24502,"compounds":"ATP + H(+) + phosphate => adenosine 5'-tetraphosphate + H2O"}
{"X":27270,"RHEA_ID":35115,"DIRECTION":"UN","MASTER_ID":35115,"ec":"2.3.1.218","compounds":"4-coumaroyl-CoA + H(+) + malonyl-CoA = (4-coumaroyl)acetyl-CoA + CO2 + CoA"}
{"X":27271,"RHEA_ID":35116,"DIRECTION":"LR","MASTER_ID":35115,"metacyc":"RXN-11220","compounds":"4-coumaroyl-CoA + H(+) + malonyl-CoA => (4-coumaroyl)acetyl-CoA + CO2 + CoA"}
{"X":27272,"RHEA_ID":24505,"DIRECTION":"LR","MASTER_ID":24504,"metacyc":"R147-RXN","reactome":"R-HSA-1237119.1","compounds":"1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 => 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)"}
{"X":27273,"RHEA_ID":24506,"compounds":"4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+) => 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2"}
{"X":27274,"RHEA_ID":35119,"DIRECTION":"UN","MASTER_ID":35119,"ec":"2.3.1.219","compounds":"(4-coumaroyl)acetyl-CoA + 4-coumaroyl-CoA + H2O = bisdemethoxycurcumin + CO2 + 2 CoA"}
{"X":27275,"RHEA_ID":35120,"DIRECTION":"LR","MASTER_ID":35119,"metacyc":"RXN-11223","compounds":"(4-coumaroyl)acetyl-CoA + 4-coumaroyl-CoA + H2O => bisdemethoxycurcumin + CO2 + 2 CoA"}
{"X":27276,"RHEA_ID":24509,"compounds":"NADP(+) + prostaglandin F2alpha => H(+) + NADPH + prostaglandin E2"}
{"X":27277,"RHEA_ID":24510,"DIRECTION":"RL","MASTER_ID":24508,"reactome":"R-HSA-2161651.2","compounds":"H(+) + NADPH + prostaglandin E2 => NADP(+) + prostaglandin F2alpha"}
{"X":27278,"RHEA_ID":35123,"compounds":"H(+)(out) + L-alanyl-D-glutamate(out) = H(+)(in) + L-alanyl-D-glutamate(in)"}
{"X":27279,"RHEA_ID":35124,"compounds":"H(+)(out) + L-alanyl-D-glutamate(out) => H(+)(in) + L-alanyl-D-glutamate(in)"}
{"X":27280,"RHEA_ID":24513,"compounds":"L-serine + pyrazole => 3-(pyrazol-1-yl)-L-alanine + H2O"}
{"X":27281,"RHEA_ID":24514,"compounds":"3-(pyrazol-1-yl)-L-alanine + H2O => L-serine + pyrazole"}
{"X":27282,"RHEA_ID":35127,"compounds":"L-alanyl-D-glutamate(out) = L-alanyl-D-glutamate(in)"}
{"X":27283,"RHEA_ID":24516,"DIRECTION":"UN","MASTER_ID":24516,"ec":"2.3.1.59","compounds":"acetyl-CoA + gentamicin C1a = CoA + H(+) + N(2')-acetylgentamicin C1a"}
{"X":27284,"RHEA_ID":24517,"compounds":"acetyl-CoA + gentamicin C1a => CoA + H(+) + N(2')-acetylgentamicin C1a"}
{"X":27285,"RHEA_ID":24518,"compounds":"CoA + H(+) + N(2')-acetylgentamicin C1a => acetyl-CoA + gentamicin C1a"}
{"X":27286,"RHEA_ID":35131,"compounds":"H(+)(out) + L-alanyl-L-glutamate(out) = H(+)(in) + L-alanyl-L-glutamate(in)"}
{"X":27287,"RHEA_ID":35132,"compounds":"H(+)(out) + L-alanyl-L-glutamate(out) => H(+)(in) + L-alanyl-L-glutamate(in)"}
{"X":27288,"RHEA_ID":24521,"DIRECTION":"LR","MASTER_ID":24520,"metacyc":"1.5.1.9-RXN","reactome":"R-HSA-70940.4","compounds":"H2O + L-saccharopine + NAD(+) => (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADH"}
{"X":27289,"RHEA_ID":24522,"compounds":"(S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADH => H2O + L-saccharopine + NAD(+)"}
{"X":27290,"RHEA_ID":35135,"compounds":"L-alanyl-L-glutamate(out) = L-alanyl-L-glutamate(in)"}
{"X":27291,"RHEA_ID":35136,"compounds":"L-alanyl-L-glutamate(out) => L-alanyl-L-glutamate(in)"}
{"X":27292,"RHEA_ID":24525,"DIRECTION":"LR","MASTER_ID":24524,"metacyc":"RXN-15060","compounds":"20-oxo-5-O-beta-D-mycaminosyltylonolide + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 5-O-beta-D-mycaminosyltylonolide + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":27293,"RHEA_ID":24526,"compounds":"5-O-beta-D-mycaminosyltylonolide + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 20-oxo-5-O-beta-D-mycaminosyltylonolide + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":27294,"RHEA_ID":35139,"DIRECTION":"UN","MASTER_ID":35139,"ec":"2.3.1.219","compounds":"(E)-4-coumaroyl-CoA + (E)-feruloylacetyl-CoA + H2O = CO2 + 2 CoA + demethoxycurcumin"}
{"X":27295,"RHEA_ID":35140,"DIRECTION":"LR","MASTER_ID":35139,"metacyc":"RXN-11225","compounds":"(E)-4-coumaroyl-CoA + (E)-feruloylacetyl-CoA + H2O => CO2 + 2 CoA + demethoxycurcumin"}
{"X":27296,"RHEA_ID":24529,"compounds":"(R)-lactaldehyde + NAD(+) => H(+) + methylglyoxal + NADH"}
{"X":27297,"RHEA_ID":24530,"compounds":"H(+) + methylglyoxal + NADH => (R)-lactaldehyde + NAD(+)"}
{"X":27298,"RHEA_ID":24532,"compounds":"2-methylbutanoyl-CoA + NAD(+) = 2-methylbut-2-enoyl-CoA + H(+) + NADH"}
{"X":27299,"RHEA_ID":24533,"compounds":"2-methylbutanoyl-CoA + NAD(+) => 2-methylbut-2-enoyl-CoA + H(+) + NADH"}
{"X":27300,"RHEA_ID":24534,"compounds":"2-methylbut-2-enoyl-CoA + H(+) + NADH => 2-methylbutanoyl-CoA + NAD(+)"}
{"X":27301,"RHEA_ID":35147,"compounds":"(2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(in) = (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(out)"}
{"X":27302,"RHEA_ID":24536,"DIRECTION":"UN","MASTER_ID":24536,"ec":"1.13.11.11","compounds":"L-tryptophan + O2 = N-formyl-L-kynurenine"}
{"X":27303,"RHEA_ID":24536,"DIRECTION":"UN","MASTER_ID":24536,"ec":"1.13.11.52","compounds":"L-tryptophan + O2 = N-formyl-L-kynurenine"}
{"X":27304,"RHEA_ID":24537,"DIRECTION":"LR","MASTER_ID":24536,"metacyc":"TRYPTOPHAN-23-DIOXYGENASE-RXN","compounds":"L-tryptophan + O2 => N-formyl-L-kynurenine"}
{"X":27305,"RHEA_ID":24538,"compounds":"N-formyl-L-kynurenine => L-tryptophan + O2"}
{"X":27306,"RHEA_ID":45097,"DIRECTION":"LR","MASTER_ID":45096,"metacyc":"RXN-9616","compounds":"(9Z)-hexadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => (9Z,12Z)-hexadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":27307,"RHEA_ID":24540,"DIRECTION":"UN","MASTER_ID":24540,"ec":"1.1.99.35","compounds":"A + D-glucose = AH2 + D-glucono-1,5-lactone"}
{"X":27308,"RHEA_ID":24541,"compounds":"A + D-glucose => AH2 + D-glucono-1,5-lactone"}
{"X":27309,"RHEA_ID":24542,"compounds":"AH2 + D-glucono-1,5-lactone => A + D-glucose"}
{"X":27310,"RHEA_ID":45101,"DIRECTION":"LR","MASTER_ID":45100,"metacyc":"RXN-16272","compounds":"6-demethylmitomycin B + S-adenosyl-L-methionine => mitomycin B + S-adenosyl-L-homocysteine"}
{"X":27311,"RHEA_ID":24544,"DIRECTION":"UN","MASTER_ID":24544,"ec":"1.4.3.13","compounds":"H2O + L-lysyl-[protein] + O2 = [protein]-(S)-2-amino-6-oxohexanoate + H2O2 + NH4(+)"}
{"X":27312,"RHEA_ID":24545,"DIRECTION":"LR","MASTER_ID":24544,"metacyc":"PROTEIN-LYSINE-6-OXIDASE-RXN","compounds":"H2O + L-lysyl-[protein] + O2 => [protein]-(S)-2-amino-6-oxohexanoate + H2O2 + NH4(+)"}
{"X":27313,"RHEA_ID":24546,"compounds":"[protein]-(S)-2-amino-6-oxohexanoate + H2O2 + NH4(+) => H2O + L-lysyl-[protein] + O2"}
{"X":27314,"RHEA_ID":35160,"DIRECTION":"LR","MASTER_ID":35159,"ecocyc":"RXN-10017","metacyc":"RXN-10017","compounds":"(2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one + H2O => (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol"}
{"X":27315,"RHEA_ID":24548,"DIRECTION":"UN","MASTER_ID":24548,"ec":"3.5.1.17","metacyc":"ACYL-LYSINE-DEACYLASE-RXN","compounds":"an N(6)-acyl-L-lysine + H2O = a carboxylate + L-lysine"}
{"X":27316,"RHEA_ID":24549,"compounds":"an N(6)-acyl-L-lysine + H2O => a carboxylate + L-lysine"}
{"X":27317,"RHEA_ID":24550,"compounds":"a carboxylate + L-lysine => an N(6)-acyl-L-lysine + H2O"}
{"X":27318,"RHEA_ID":35164,"compounds":"H(+)(out) + minocycline(in) => H(+)(in) + minocycline(out)"}
{"X":27319,"RHEA_ID":24552,"compounds":"5alpha-cholestan-3-one + NADP(+) = cholest-4-en-3-one + H(+) + NADPH"}
{"X":27320,"RHEA_ID":24553,"compounds":"5alpha-cholestan-3-one + NADP(+) => cholest-4-en-3-one + H(+) + NADPH"}
{"X":27321,"RHEA_ID":24554,"DIRECTION":"RL","MASTER_ID":24552,"metacyc":"CHOLESTENONE-5-ALPHA-REDUCTASE-RXN","compounds":"cholest-4-en-3-one + H(+) + NADPH => 5alpha-cholestan-3-one + NADP(+)"}
{"X":27322,"RHEA_ID":35168,"compounds":"minocycline(in) => minocycline(out)"}
{"X":27323,"RHEA_ID":24556,"DIRECTION":"UN","MASTER_ID":24556,"ec":"1.3.1.65","compounds":"5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one + NAD(+) = 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + H(+) + NADH"}
{"X":27324,"RHEA_ID":24557,"DIRECTION":"LR","MASTER_ID":24556,"metacyc":"RXN-643","compounds":"5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one + NAD(+) => 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + H(+) + NADH"}
{"X":27325,"RHEA_ID":24558,"compounds":"5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + H(+) + NADH => 5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one + NAD(+)"}
{"X":27326,"RHEA_ID":45117,"compounds":"(4R)-ipsdienol + NADP(+) => H(+) + ipsdienone + NADPH"}
{"X":27327,"RHEA_ID":24560,"DIRECTION":"UN","MASTER_ID":24560,"ec":"2.3.1.30","compounds":"acetyl-CoA + L-serine = CoA + O-acetyl-L-serine"}
{"X":27328,"RHEA_ID":24561,"compounds":"acetyl-CoA + L-serine => CoA + O-acetyl-L-serine"}
{"X":27329,"RHEA_ID":24562,"compounds":"CoA + O-acetyl-L-serine => acetyl-CoA + L-serine"}
{"X":27330,"RHEA_ID":45121,"compounds":"(4R)-ipsdienol + NAD(+) => H(+) + ipsdienone + NADH"}
{"X":27331,"RHEA_ID":24564,"DIRECTION":"UN","MASTER_ID":24564,"ec":"2.8.3.5","compounds":"a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate"}
{"X":27332,"RHEA_ID":24565,"compounds":"a 3-oxo acid + succinyl-CoA => a 3-oxoacyl-CoA + succinate"}
{"X":27333,"RHEA_ID":24566,"compounds":"a 3-oxoacyl-CoA + succinate => a 3-oxo acid + succinyl-CoA"}
{"X":27334,"RHEA_ID":45125,"compounds":"acarbose + ATP => acarbose 7(IV)-phosphate + ADP + H(+)"}
{"X":27335,"RHEA_ID":24568,"DIRECTION":"UN","MASTER_ID":24568,"ec":"3.2.1.85","compounds":"a 6-phospho-beta-D-galactoside + H2O = an alcohol + D-galactose 6-phosphate"}
{"X":27336,"RHEA_ID":24569,"DIRECTION":"LR","MASTER_ID":24568,"metacyc":"6-PHOSPHO-BETA-GALACTOSIDASE-RXN","compounds":"a 6-phospho-beta-D-galactoside + H2O => an alcohol + D-galactose 6-phosphate"}
{"X":27337,"RHEA_ID":24570,"compounds":"an alcohol + D-galactose 6-phosphate => a 6-phospho-beta-D-galactoside + H2O"}
{"X":27338,"RHEA_ID":35184,"compounds":"5-hydroxythiophene-2-carbonyl-CoA + H2O => 4-carboxy-2-thioxobutanoyl-CoA"}
{"X":27339,"RHEA_ID":24572,"DIRECTION":"UN","MASTER_ID":24572,"ec":"2.4.1.4","compounds":"[(1->4)-alpha-D-glucosyl](n) + sucrose = [(1->4)-alpha-D-glucosyl](n+1) + D-fructose"}
{"X":27340,"RHEA_ID":24573,"DIRECTION":"LR","MASTER_ID":24572,"metacyc":"AMYLOSUCRASE-RXN","compounds":"[(1->4)-alpha-D-glucosyl](n) + sucrose => [(1->4)-alpha-D-glucosyl](n+1) + D-fructose"}
{"X":27341,"RHEA_ID":24574,"compounds":"[(1->4)-alpha-D-glucosyl](n+1) + D-fructose => [(1->4)-alpha-D-glucosyl](n) + sucrose"}
{"X":27342,"RHEA_ID":45133,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate"}
{"X":27343,"RHEA_ID":24576,"DIRECTION":"UN","MASTER_ID":24576,"ec":"3.6.1.1","compounds":"diphosphate + H2O = H(+) + 2 phosphate"}
{"X":27344,"RHEA_ID":24577,"DIRECTION":"LR","MASTER_ID":24576,"ecocyc":"INORGPYROPHOSPHAT-RXN","reactome":"R-HSA-6788912.1","compounds":"diphosphate + H2O => H(+) + 2 phosphate"}
{"X":27345,"RHEA_ID":24577,"DIRECTION":"LR","MASTER_ID":24576,"ecocyc":"INORGPYROPHOSPHAT-RXN","reactome":"R-HSA-449937.2","compounds":"diphosphate + H2O => H(+) + 2 phosphate"}
{"X":27346,"RHEA_ID":24577,"DIRECTION":"LR","MASTER_ID":24576,"ecocyc":"INORGPYROPHOSPHAT-RXN","reactome":"R-HSA-71732.5","compounds":"diphosphate + H2O => H(+) + 2 phosphate"}
{"X":27347,"RHEA_ID":24578,"compounds":"H(+) + 2 phosphate => diphosphate + H2O"}
{"X":27348,"RHEA_ID":24580,"DIRECTION":"UN","MASTER_ID":24580,"ec":"3.1.3.50","compounds":"D-sorbitol 6-phosphate + H2O = D-sorbitol + phosphate"}
{"X":27349,"RHEA_ID":35196,"compounds":"L-quinate(in) => L-quinate(out)"}
{"X":27350,"RHEA_ID":24582,"compounds":"D-sorbitol + phosphate => D-sorbitol 6-phosphate + H2O"}
{"X":27351,"RHEA_ID":35198,"compounds":"L-quinate(in) <=> L-quinate(out)"}
{"X":27352,"RHEA_ID":24584,"compounds":"(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + H2O + NAD(+) = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + 2 H(+) + NADH"}
{"X":27353,"RHEA_ID":35200,"compounds":"(S,S)-tartrate(out) => (S,S)-tartrate(in)"}
{"X":27354,"RHEA_ID":24586,"compounds":"(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + 2 H(+) + NADH => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + H2O + NAD(+)"}
{"X":27355,"RHEA_ID":35202,"compounds":"(S,S)-tartrate(out) <=> (S,S)-tartrate(in)"}
{"X":27356,"RHEA_ID":24588,"DIRECTION":"UN","MASTER_ID":24588,"ec":"2.7.1.54","metacyc":"D-ARABINOKINASE-RXN","compounds":"ATP + D-arabinose = ADP + D-arabinose 5-phosphate + H(+)"}
{"X":27357,"RHEA_ID":35208,"DIRECTION":"LR","MASTER_ID":35207,"metacyc":"RXN-14003","reactome":"R-HSA-2509816.4","compounds":"H2O + IDP => H(+) + IMP + phosphate"}
{"X":27358,"RHEA_ID":24590,"compounds":"ADP + D-arabinose 5-phosphate + H(+) => ATP + D-arabinose"}
{"X":27359,"RHEA_ID":55134,"compounds":"AMP + D-alanyl-[D-alanyl-carrier protein] + diphosphate => ATP + D-alanine + holo-[D-alanyl-carrier protein]"}
{"X":27360,"RHEA_ID":24592,"DIRECTION":"UN","MASTER_ID":24592,"ec":"2.7.7.14","compounds":"CTP + H(+) + phosphoethanolamine = CDP-ethanolamine + diphosphate"}
{"X":27361,"RHEA_ID":35212,"DIRECTION":"LR","MASTER_ID":35211,"metacyc":"RXN-14004","reactome":"R-HSA-2509793.4","compounds":"dIDP + H2O => dIMP + H(+) + phosphate"}
{"X":27362,"RHEA_ID":24594,"compounds":"CDP-ethanolamine + diphosphate => CTP + H(+) + phosphoethanolamine"}
{"X":27363,"RHEA_ID":55138,"compounds":"D-alanyl-5'-AMP + diphosphate => ATP + D-alanine + H(+)"}
{"X":27364,"RHEA_ID":24596,"DIRECTION":"UN","MASTER_ID":24596,"ec":"2.3.1.33","compounds":"acetyl-CoA + L-histidine = CoA + H(+) + N(alpha)-acetyl-L-histidine"}
{"X":27365,"RHEA_ID":35216,"compounds":"H2O + XDP => H(+) + phosphate + XMP"}
{"X":27366,"RHEA_ID":24598,"compounds":"CoA + H(+) + N(alpha)-acetyl-L-histidine => acetyl-CoA + L-histidine"}
{"X":27367,"RHEA_ID":35218,"compounds":"H2O + XDP <=> H(+) + phosphate + XMP"}
{"X":27368,"RHEA_ID":24600,"DIRECTION":"UN","MASTER_ID":24600,"ec":"1.8.3.1","compounds":"H2O + O2 + sulfite = H2O2 + sulfate"}
{"X":27369,"RHEA_ID":24601,"DIRECTION":"LR","MASTER_ID":24600,"metacyc":"SULFITE-OXIDASE-RXN","reactome":"R-HSA-1614544.2","compounds":"H2O + O2 + sulfite => H2O2 + sulfate"}
{"X":27370,"RHEA_ID":35221,"compounds":"8-oxo-dAMP + H(+) + phosphate => 8-oxo-dADP + H2O"}
{"X":27371,"RHEA_ID":24604,"DIRECTION":"UN","MASTER_ID":24604,"ec":"2.1.1.160","compounds":"7-methylxanthine + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + theobromine"}
{"X":27372,"RHEA_ID":24604,"DIRECTION":"UN","MASTER_ID":24604,"ec":"2.1.1.159","compounds":"7-methylxanthine + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + theobromine"}
{"X":27373,"RHEA_ID":35225,"compounds":"2-hydroxy-dAMP + H(+) + phosphate => 2-oxo-dADP + H2O"}
{"X":27374,"RHEA_ID":24606,"compounds":"H(+) + S-adenosyl-L-homocysteine + theobromine => 7-methylxanthine + S-adenosyl-L-methionine"}
{"X":27375,"RHEA_ID":35227,"compounds":"H(+)(out) + rifampicin(in) = H(+)(in) + rifampicin(out)"}
{"X":27376,"RHEA_ID":24608,"DIRECTION":"UN","MASTER_ID":24608,"ec":"4.2.1.41","compounds":"5-dehydro-4-deoxy-D-glucarate + H(+) = 2,5-dioxopentanoate + CO2 + H2O"}
{"X":27377,"RHEA_ID":24609,"DIRECTION":"LR","MASTER_ID":24608,"metacyc":"4.2.1.41-RXN","compounds":"5-dehydro-4-deoxy-D-glucarate + H(+) => 2,5-dioxopentanoate + CO2 + H2O"}
{"X":27378,"RHEA_ID":24610,"compounds":"2,5-dioxopentanoate + CO2 + H2O => 5-dehydro-4-deoxy-D-glucarate + H(+)"}
{"X":27379,"RHEA_ID":35231,"compounds":"rifampicin(in) = rifampicin(out)"}
{"X":27380,"RHEA_ID":24612,"DIRECTION":"UN","MASTER_ID":24612,"ec":"1.1.1.62","compounds":"17beta-estradiol + NAD(+) = estrone + H(+) + NADH"}
{"X":27381,"RHEA_ID":35233,"compounds":"rifampicin(out) => rifampicin(in)"}
{"X":27382,"RHEA_ID":24614,"DIRECTION":"RL","MASTER_ID":24612,"metacyc":"ESTRADIOL-17-BETA-DEHYDROGENASE-RXN","compounds":"estrone + H(+) + NADH => 17beta-estradiol + NAD(+)"}
{"X":27383,"RHEA_ID":35235,"compounds":"H(+)(out) + tetracycline(in) = H(+)(in) + tetracycline(out)"}
{"X":27384,"RHEA_ID":24616,"DIRECTION":"UN","MASTER_ID":24616,"ec":"1.1.1.62","compounds":"17beta-estradiol + NADP(+) = estrone + H(+) + NADPH"}
{"X":27385,"RHEA_ID":35237,"compounds":"H(+)(in) + tetracycline(out) => H(+)(out) + tetracycline(in)"}
{"X":27386,"RHEA_ID":24617,"DIRECTION":"LR","MASTER_ID":24616,"reactome":"R-HSA-5696822.1","compounds":"17beta-estradiol + NADP(+) => estrone + H(+) + NADPH"}
{"X":27387,"RHEA_ID":24617,"DIRECTION":"LR","MASTER_ID":24616,"reactome":"R-HSA-6810594.1","compounds":"17beta-estradiol + NADP(+) => estrone + H(+) + NADPH"}
{"X":27388,"RHEA_ID":24617,"DIRECTION":"LR","MASTER_ID":24616,"reactome":"R-HSA-8862137.2","compounds":"17beta-estradiol + NADP(+) => estrone + H(+) + NADPH"}
{"X":27389,"RHEA_ID":24618,"DIRECTION":"RL","MASTER_ID":24616,"metacyc":"ESTRADIOL-17-BETA-DEHYDROGENASE-RXN","reactome":"R-HSA-804969.2","compounds":"estrone + H(+) + NADPH => 17beta-estradiol + NADP(+)"}
{"X":27390,"RHEA_ID":55166,"compounds":"H2O + L-isoleucine-12-hydroxyjasmonate + NADP(+) => a jasmonyl-L-isoleucinate + H(+) + NADPH + O2"}
{"X":27391,"RHEA_ID":24620,"DIRECTION":"UN","MASTER_ID":24620,"ec":"1.1.1.73","compounds":"NAD(+) + octan-1-ol = H(+) + NADH + octanal"}
{"X":27392,"RHEA_ID":24621,"compounds":"NAD(+) + octan-1-ol => H(+) + NADH + octanal"}
{"X":27393,"RHEA_ID":24622,"compounds":"H(+) + NADH + octanal => NAD(+) + octan-1-ol"}
{"X":27394,"RHEA_ID":45187,"compounds":"5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + NH4(+) <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + H2O"}
{"X":27395,"RHEA_ID":24624,"DIRECTION":"UN","MASTER_ID":24624,"ec":"6.1.1.3","compounds":"ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)"}
{"X":27396,"RHEA_ID":24625,"DIRECTION":"LR","MASTER_ID":24624,"ecocyc":"THREONINE--TRNA-LIGASE-RXN","metacyc":"THREONINE--TRNA-LIGASE-RXN","compounds":"ATP + L-threonine + tRNA(Thr) => AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)"}
{"X":27397,"RHEA_ID":24626,"compounds":"AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr) => ATP + L-threonine + tRNA(Thr)"}
{"X":27398,"RHEA_ID":45191,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine"}
{"X":27399,"RHEA_ID":24628,"DIRECTION":"UN","MASTER_ID":24628,"ec":"1.7.1.4","compounds":"2 H2O + 3 NAD(+) + NH4(+) = 5 H(+) + 3 NADH + nitrite"}
{"X":27400,"RHEA_ID":24628,"DIRECTION":"UN","MASTER_ID":24628,"ec":"1.7.1.15","compounds":"2 H2O + 3 NAD(+) + NH4(+) = 5 H(+) + 3 NADH + nitrite"}
{"X":27401,"RHEA_ID":24629,"compounds":"2 H2O + 3 NAD(+) + NH4(+) => 5 H(+) + 3 NADH + nitrite"}
{"X":27402,"RHEA_ID":35254,"compounds":"alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(in) + ATP + H2O <=> ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(out) + H(+) + phosphate"}
{"X":27403,"RHEA_ID":24630,"DIRECTION":"RL","MASTER_ID":24628,"ecocyc":"RXN-13854","metacyc":"RXN0-6377","compounds":"5 H(+) + 3 NADH + nitrite => 2 H2O + 3 NAD(+) + NH4(+)"}
{"X":27404,"RHEA_ID":24632,"DIRECTION":"UN","MASTER_ID":24632,"ec":"1.7.1.4","compounds":"2 H2O + 3 NADP(+) + NH4(+) = 5 H(+) + 3 NADPH + nitrite"}
{"X":27405,"RHEA_ID":35258,"compounds":"ATP + H2O + lipid A-core(in) <=> ADP + H(+) + lipid A-core(out) + phosphate"}
{"X":27406,"RHEA_ID":24634,"DIRECTION":"RL","MASTER_ID":24632,"metacyc":"RXN0-6377","compounds":"5 H(+) + 3 NADPH + nitrite => 2 H2O + 3 NADP(+) + NH4(+)"}
{"X":27407,"RHEA_ID":24636,"DIRECTION":"UN","MASTER_ID":24636,"ec":"1.12.1.2","compounds":"H2 + NAD(+) = H(+) + NADH"}
{"X":27408,"RHEA_ID":35262,"compounds":"7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(in) + ATP + H2O <=> 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(out) + ADP + H(+) + phosphate"}
{"X":27409,"RHEA_ID":24637,"compounds":"H2 + NAD(+) => H(+) + NADH"}
{"X":27410,"RHEA_ID":24638,"compounds":"H(+) + NADH => H2 + NAD(+)"}
{"X":27411,"RHEA_ID":35266,"compounds":"a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + a fatty acid + H(+) <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O"}
{"X":27412,"RHEA_ID":24640,"compounds":"ergosteryl 3-beta-D-glucoside + H2O = D-glucose + ergosterol"}
{"X":27413,"RHEA_ID":24641,"DIRECTION":"LR","MASTER_ID":24640,"metacyc":"RXN3O-9782","compounds":"ergosteryl 3-beta-D-glucoside + H2O => D-glucose + ergosterol"}
{"X":27414,"RHEA_ID":24642,"compounds":"D-glucose + ergosterol => ergosteryl 3-beta-D-glucoside + H2O"}
{"X":27415,"RHEA_ID":35270,"compounds":"ethanol(in) <=> ethanol(out)"}
{"X":27416,"RHEA_ID":24660,"compounds":"H(+) + L-arginine + NADPH + O2 = H2O + N(omega)-hydroxy-L-arginine + NADP(+)"}
{"X":27417,"RHEA_ID":24661,"DIRECTION":"LR","MASTER_ID":24660,"metacyc":"RXN-13564","compounds":"H(+) + L-arginine + NADPH + O2 => H2O + N(omega)-hydroxy-L-arginine + NADP(+)"}
{"X":27418,"RHEA_ID":24661,"DIRECTION":"LR","MASTER_ID":24660,"metacyc":"RXN-13566","compounds":"H(+) + L-arginine + NADPH + O2 => H2O + N(omega)-hydroxy-L-arginine + NADP(+)"}
{"X":27419,"RHEA_ID":35274,"compounds":"a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}
{"X":27420,"RHEA_ID":35275,"compounds":"3-hydroxyoctadecanoyl-CoA + NAD(+) = 3-oxooctadecanoyl-CoA + H(+) + NADH"}
{"X":27421,"RHEA_ID":24664,"compounds":"2 N(omega)-hydroxy-L-arginine + NADPH + 2 O2 = H(+) + 2 H2O + 2 L-citrulline + NADP(+) + 2 nitric oxide"}
{"X":27422,"RHEA_ID":24665,"DIRECTION":"LR","MASTER_ID":24664,"metacyc":"RXN-13567","compounds":"2 N(omega)-hydroxy-L-arginine + NADPH + 2 O2 => H(+) + 2 H2O + 2 L-citrulline + NADP(+) + 2 nitric oxide"}
{"X":27423,"RHEA_ID":35278,"compounds":"3-hydroxyoctadecanoyl-CoA + NAD(+) <=> 3-oxooctadecanoyl-CoA + H(+) + NADH"}
{"X":27424,"RHEA_ID":24666,"compounds":"H(+) + 2 H2O + 2 L-citrulline + NADP(+) + 2 nitric oxide => 2 N(omega)-hydroxy-L-arginine + NADPH + 2 O2"}
{"X":27425,"RHEA_ID":35280,"compounds":"acetyl-CoA + hexadecanoyl-CoA => 3-oxooctadecanoyl-CoA + CoA"}
{"X":27426,"RHEA_ID":24670,"DIRECTION":"UN","MASTER_ID":24670,"ec":"1.17.1.4","compounds":"H2O + hypoxanthine + NAD(+) = H(+) + NADH + xanthine"}
{"X":27427,"RHEA_ID":24671,"DIRECTION":"LR","MASTER_ID":24670,"ecocyc":"RXN-7682","metacyc":"RXN-7682","compounds":"H2O + hypoxanthine + NAD(+) => H(+) + NADH + xanthine"}
{"X":27428,"RHEA_ID":24672,"compounds":"H(+) + NADH + xanthine => H2O + hypoxanthine + NAD(+)"}
{"X":27429,"RHEA_ID":35284,"compounds":"(9Z)-octadecenoyl-CoA => (2E)-octadecenoyl-CoA"}
{"X":27430,"RHEA_ID":24674,"DIRECTION":"UN","MASTER_ID":24674,"ec":"2.7.1.213","compounds":"ATP + cytidine = ADP + CMP + H(+)"}
{"X":27431,"RHEA_ID":35286,"compounds":"(9Z)-octadecenoyl-CoA <=> (2E)-octadecenoyl-CoA"}
{"X":27432,"RHEA_ID":24675,"DIRECTION":"LR","MASTER_ID":24674,"ecocyc":"CYTIKIN-RXN","metacyc":"CYTIKIN-RXN","reactome":"R-HSA-73598.4","compounds":"ATP + cytidine => ADP + CMP + H(+)"}
{"X":27433,"RHEA_ID":24676,"compounds":"ADP + CMP + H(+) => ATP + cytidine"}
{"X":27434,"RHEA_ID":35289,"compounds":"chloramphenicol(out) => chloramphenicol(in)"}
{"X":27435,"RHEA_ID":24678,"DIRECTION":"UN","MASTER_ID":24678,"ec":"4.2.1.147","compounds":"5,6,7,8-tetrahydromethanopterin + formaldehyde = 5,10-methylenetetrahydromethanopterin + H2O"}
{"X":27436,"RHEA_ID":24679,"DIRECTION":"LR","MASTER_ID":24678,"metacyc":"RXN-2882","compounds":"5,6,7,8-tetrahydromethanopterin + formaldehyde => 5,10-methylenetetrahydromethanopterin + H2O"}
{"X":27437,"RHEA_ID":24680,"compounds":"5,10-methylenetetrahydromethanopterin + H2O => 5,6,7,8-tetrahydromethanopterin + formaldehyde"}
{"X":27438,"RHEA_ID":35293,"compounds":"3-oxoisopentadecanoyl-CoA + CO2 + CoA => 11-methyldodecanoyl-CoA + H(+) + malonyl-CoA"}
{"X":27439,"RHEA_ID":35294,"compounds":"11-methyldodecanoyl-CoA + H(+) + malonyl-CoA <=> 3-oxoisopentadecanoyl-CoA + CO2 + CoA"}
{"X":27440,"RHEA_ID":24683,"compounds":"5,10-methylenetetrahydromethanopterin + NADP(+) => 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADPH"}
{"X":27441,"RHEA_ID":24684,"compounds":"5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADPH => 5,10-methylenetetrahydromethanopterin + NADP(+)"}
{"X":27442,"RHEA_ID":35297,"compounds":"AMP + H2O + W-molybdopterin cofactor => adenylyl-molybdopterin + H(+) + tungstate"}
{"X":27443,"RHEA_ID":35298,"compounds":"adenylyl-molybdopterin + H(+) + tungstate <=> AMP + H2O + W-molybdopterin cofactor"}
{"X":27444,"RHEA_ID":24687,"compounds":"H2O + N-formylmethanofuran => formate + methanofuran"}
{"X":27445,"RHEA_ID":24688,"compounds":"formate + methanofuran => H2O + N-formylmethanofuran"}
{"X":27446,"RHEA_ID":35301,"DIRECTION":"RL","MASTER_ID":35299,"reactome":"R-HSA-548818.2","compounds":"3-oxooctadecanoyl-CoA + H(+) + NADPH => 3-hydroxyoctadecanoyl-CoA + NADP(+)"}
{"X":27447,"RHEA_ID":35302,"compounds":"3-hydroxyoctadecanoyl-CoA + NADP(+) <=> 3-oxooctadecanoyl-CoA + H(+) + NADPH"}
{"X":27448,"RHEA_ID":24691,"compounds":"acetate + eugenol + NADP(+) => coniferyl acetate + NADPH"}
{"X":27449,"RHEA_ID":24692,"DIRECTION":"RL","MASTER_ID":24690,"metacyc":"RXN-9245","compounds":"coniferyl acetate + NADPH => acetate + eugenol + NADP(+)"}
{"X":27450,"RHEA_ID":35305,"compounds":"3-oxoisopentadecanoyl-CoA + H(+) + NADPH => 3-hydroxyisopentadecanoyl-CoA + NADP(+)"}
{"X":27451,"RHEA_ID":35306,"compounds":"3-hydroxyisopentadecanoyl-CoA + NADP(+) <=> 3-oxoisopentadecanoyl-CoA + H(+) + NADPH"}
{"X":27452,"RHEA_ID":24695,"compounds":"acetate + NADP(+) + trans-isoeugenol => coniferyl acetate + NADPH"}
{"X":27453,"RHEA_ID":24696,"DIRECTION":"RL","MASTER_ID":24694,"metacyc":"RXN-9246","compounds":"coniferyl acetate + NADPH => acetate + NADP(+) + trans-isoeugenol"}
{"X":27454,"RHEA_ID":35309,"compounds":"2,5-dihydroxybenzoate + H2O + NAD(+) => H(+) + NADH + O2 + salicylate"}
{"X":27455,"RHEA_ID":45251,"compounds":"butanoate(out) <=> butanoate(in)"}
{"X":27456,"RHEA_ID":24699,"DIRECTION":"LR","MASTER_ID":24698,"ecocyc":"RXN-16286","metacyc":"RXN-16286","compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A => 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + a 1,2-diacyl-sn-glycerol"}
{"X":27457,"RHEA_ID":24700,"compounds":"7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + a 1,2-diacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A"}
{"X":27458,"RHEA_ID":24702,"DIRECTION":"UN","MASTER_ID":24702,"ec":"1.1.1.305","compounds":"NAD(+) + UDP-alpha-D-glucuronate = CO2 + NADH + UDP-beta-L-threo-pentopyranos-4-ulose"}
{"X":27459,"RHEA_ID":24703,"DIRECTION":"LR","MASTER_ID":24702,"ecocyc":"RXN0-1861","metacyc":"RXN0-1861","compounds":"NAD(+) + UDP-alpha-D-glucuronate => CO2 + NADH + UDP-beta-L-threo-pentopyranos-4-ulose"}
{"X":27460,"RHEA_ID":24704,"compounds":"CO2 + NADH + UDP-beta-L-threo-pentopyranos-4-ulose => NAD(+) + UDP-alpha-D-glucuronate"}
{"X":27461,"RHEA_ID":35317,"compounds":"3-oxooctadecanoyl-CoA + CO2 + CoA => H(+) + hexadecanoyl-CoA + malonyl-CoA"}
{"X":27462,"RHEA_ID":35318,"compounds":"H(+) + hexadecanoyl-CoA + malonyl-CoA <=> 3-oxooctadecanoyl-CoA + CO2 + CoA"}
{"X":27463,"RHEA_ID":24707,"DIRECTION":"LR","MASTER_ID":24706,"ecocyc":"RXN0-1862","metacyc":"RXN0-1862","compounds":"(6S)-10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinose => (6S)-5,6,7,8-tetrahydrofolate + H(+) + UDP-4-deoxy-4-formamido-beta-L-arabinose"}
{"X":27464,"RHEA_ID":24708,"compounds":"(6S)-5,6,7,8-tetrahydrofolate + H(+) + UDP-4-deoxy-4-formamido-beta-L-arabinose => (6S)-10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinose"}
{"X":27465,"RHEA_ID":35321,"compounds":"3-oxoeicosanoyl-CoA + CO2 + CoA => H(+) + malonyl-CoA + octadecanoyl-CoA"}
{"X":27466,"RHEA_ID":35322,"compounds":"H(+) + malonyl-CoA + octadecanoyl-CoA <=> 3-oxoeicosanoyl-CoA + CO2 + CoA"}
{"X":27467,"RHEA_ID":24711,"compounds":"2-oxoglutarate + UDP-4-amino-4-deoxy-beta-L-arabinose => L-glutamate + UDP-beta-L-threo-pentopyranos-4-ulose"}
{"X":27468,"RHEA_ID":24712,"compounds":"L-glutamate + UDP-beta-L-threo-pentopyranos-4-ulose => 2-oxoglutarate + UDP-4-amino-4-deoxy-beta-L-arabinose"}
{"X":27469,"RHEA_ID":35325,"DIRECTION":"RL","MASTER_ID":35323,"ecocyc":"RXN-14014","metacyc":"RXN-14014","compounds":"(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH => (S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+)"}
{"X":27470,"RHEA_ID":45267,"compounds":"(9Z,12Z)-octadecadienoate(out) <=> (9Z,12Z)-octadecadienoate(in)"}
{"X":27471,"RHEA_ID":24723,"compounds":"H(+) + L-methionyl(44)-[F-actin] + NADPH + O2 => H2O + L-methionyl(44)-(R)-S-oxide-[F-actin] + NADP(+)"}
{"X":27472,"RHEA_ID":24724,"compounds":"H2O + L-methionyl(44)-(R)-S-oxide-[F-actin] + NADP(+) => H(+) + L-methionyl(44)-[F-actin] + NADPH + O2"}
{"X":27473,"RHEA_ID":24725,"DIRECTION":"BI","MASTER_ID":24722,"metacyc":"RXN-17512","compounds":"H(+) + L-methionyl(44)-[F-actin] + NADPH + O2 <=> H2O + L-methionyl(44)-(R)-S-oxide-[F-actin] + NADP(+)"}
{"X":27474,"RHEA_ID":24726,"DIRECTION":"UN","MASTER_ID":24726,"ec":"2.1.1.328","compounds":"N-demethylindolmycin + S-adenosyl-L-methionine = H(+) + indolmycin + S-adenosyl-L-homocysteine"}
{"X":27475,"RHEA_ID":24727,"DIRECTION":"LR","MASTER_ID":24726,"metacyc":"RXN-17534","compounds":"N-demethylindolmycin + S-adenosyl-L-methionine => H(+) + indolmycin + S-adenosyl-L-homocysteine"}
{"X":27476,"RHEA_ID":24728,"compounds":"H(+) + indolmycin + S-adenosyl-L-homocysteine => N-demethylindolmycin + S-adenosyl-L-methionine"}
{"X":27477,"RHEA_ID":35333,"DIRECTION":"RL","MASTER_ID":35331,"ecocyc":"RXN-14014","metacyc":"RXN-14014","compounds":"(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH => (S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+)"}
{"X":27478,"RHEA_ID":45275,"compounds":"12-phosphooxy-(9Z)-octadecenoate + H2O <=> 12-hydroxy-(9Z)-octadecenoate + phosphate"}
{"X":27479,"RHEA_ID":24731,"compounds":"anthranilate + H(+) => aniline + CO2"}
{"X":27480,"RHEA_ID":24732,"compounds":"aniline + CO2 => anthranilate + H(+)"}
{"X":27481,"RHEA_ID":35338,"compounds":"H(+) + isopentadecanoyl-CoA + malonyl-CoA <=> 3-oxoisoheptadecanoyl-CoA + CO2 + CoA"}
{"X":27482,"RHEA_ID":24735,"DIRECTION":"LR","MASTER_ID":24734,"metacyc":"RXN-14300","reactome":"R-HSA-880033.2","compounds":"2-oxoglutarate + 4-hydroxybutanoate => (R)-2-hydroxyglutarate + succinate semialdehyde"}
{"X":27483,"RHEA_ID":24736,"DIRECTION":"RL","MASTER_ID":24734,"reactome":"R-HSA-880002.3","compounds":"(R)-2-hydroxyglutarate + succinate semialdehyde => 2-oxoglutarate + 4-hydroxybutanoate"}
{"X":27484,"RHEA_ID":24737,"compounds":"2-oxoglutarate + 4-hydroxybutanoate <=> (R)-2-hydroxyglutarate + succinate semialdehyde"}
{"X":27485,"RHEA_ID":35342,"compounds":"3-hydroxyicosanoyl-CoA + NADP(+) <=> 3-oxoeicosanoyl-CoA + H(+) + NADPH"}
{"X":27486,"RHEA_ID":24739,"compounds":"(6R)-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) => 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH"}
{"X":27487,"RHEA_ID":24740,"DIRECTION":"RL","MASTER_ID":24738,"metacyc":"RXN-8853","compounds":"6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH => (6R)-5,6,7,8-tetrahydrobiopterin + 2 NADP(+)"}
{"X":27488,"RHEA_ID":24741,"compounds":"(6R)-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH"}
{"X":27489,"RHEA_ID":35346,"compounds":"3-hydroxydocosanoyl-CoA + NADP(+) <=> 3-oxodocosanoyl-CoA + H(+) + NADPH"}
{"X":27490,"RHEA_ID":24743,"compounds":"2-aminobut-2-enoate + H2O => 2-oxobutanoate + NH4(+)"}
{"X":27491,"RHEA_ID":24744,"compounds":"2-oxobutanoate + NH4(+) => 2-aminobut-2-enoate + H2O"}
{"X":27492,"RHEA_ID":35349,"compounds":"(2E)-octadecenoyl-CoA + H2O => 3-hydroxyoctadecanoyl-CoA"}
{"X":27493,"RHEA_ID":35350,"compounds":"3-hydroxyoctadecanoyl-CoA <=> (2E)-octadecenoyl-CoA + H2O"}
{"X":27494,"RHEA_ID":24747,"DIRECTION":"LR","MASTER_ID":24746,"metacyc":"RXN-14301","compounds":"L-methionine => 2-aminobut-2-enoate + methanethiol"}
{"X":27495,"RHEA_ID":24748,"compounds":"2-aminobut-2-enoate + methanethiol => L-methionine"}
{"X":27496,"RHEA_ID":35353,"DIRECTION":"RL","MASTER_ID":35351,"reactome":"R-HSA-548831.2","compounds":"(2E)-octadecenoyl-CoA + H(+) + NADPH => NADP(+) + octadecanoyl-CoA"}
{"X":27497,"RHEA_ID":35354,"compounds":"NADP(+) + octadecanoyl-CoA <=> (2E)-octadecenoyl-CoA + H(+) + NADPH"}
{"X":27498,"RHEA_ID":24753,"compounds":"2 oxidized [2Fe-2S]-[ferredoxin] + primary fluorescent chlorophyll catabolite => 3 H(+) + red chlorophyll catabolite + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":27499,"RHEA_ID":24754,"DIRECTION":"RL","MASTER_ID":24752,"metacyc":"RXN-7741","compounds":"3 H(+) + red chlorophyll catabolite + 2 reduced [2Fe-2S]-[ferredoxin] => 2 oxidized [2Fe-2S]-[ferredoxin] + primary fluorescent chlorophyll catabolite"}
{"X":27500,"RHEA_ID":35357,"compounds":"(2E)-13-methyltetradecenoyl-CoA + H2O => 3-hydroxyisopentadecanoyl-CoA"}
{"X":27501,"RHEA_ID":35358,"compounds":"3-hydroxyisopentadecanoyl-CoA <=> (2E)-13-methyltetradecenoyl-CoA + H2O"}
{"X":27502,"RHEA_ID":24757,"DIRECTION":"LR","MASTER_ID":24756,"metacyc":"RXN-7740","compounds":"H(+) + NADPH + O2 + pheophorbide a => NADP(+) + red chlorophyll catabolite"}
{"X":27503,"RHEA_ID":24758,"compounds":"NADP(+) + red chlorophyll catabolite => H(+) + NADPH + O2 + pheophorbide a"}
{"X":27504,"RHEA_ID":35361,"compounds":"(2E)-15-methylhexadecenoyl-CoA + H2O => 3-hydroxyisoheptadecanoyl-CoA"}
{"X":27505,"RHEA_ID":35362,"compounds":"3-hydroxyisoheptadecanoyl-CoA <=> (2E)-15-methylhexadecenoyl-CoA + H2O"}
{"X":27506,"RHEA_ID":24761,"compounds":"H(+) + L-dopa + NADH => 3-(3,4-dihydroxyphenyl)propanoate + NAD(+) + NH4(+)"}
{"X":27507,"RHEA_ID":24762,"compounds":"3-(3,4-dihydroxyphenyl)propanoate + NAD(+) + NH4(+) => H(+) + L-dopa + NADH"}
{"X":27508,"RHEA_ID":35365,"compounds":"isopentadecanoyl-CoA + NADP(+) => (2E)-13-methyltetradecenoyl-CoA + H(+) + NADPH"}
{"X":27509,"RHEA_ID":35366,"compounds":"(2E)-13-methyltetradecenoyl-CoA + H(+) + NADPH <=> isopentadecanoyl-CoA + NADP(+)"}
{"X":27510,"RHEA_ID":24765,"DIRECTION":"LR","MASTER_ID":24764,"metacyc":"5.1.3.23-RXN","compounds":"UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate => UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate"}
{"X":27511,"RHEA_ID":24766,"compounds":"UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate => UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate"}
{"X":27512,"RHEA_ID":35369,"compounds":"isoheptadecanoyl-coA + NADP(+) => (2E)-15-methylhexadecenoyl-CoA + H(+) + NADPH"}
{"X":27513,"RHEA_ID":35370,"compounds":"(2E)-15-methylhexadecenoyl-CoA + H(+) + NADPH <=> isoheptadecanoyl-coA + NADP(+)"}
{"X":27514,"RHEA_ID":24769,"compounds":"7(1)-hydroxychlorophyllide a + NAD(+) => chlorophyllide b + H(+) + NADH"}
{"X":27515,"RHEA_ID":24770,"compounds":"chlorophyllide b + H(+) + NADH => 7(1)-hydroxychlorophyllide a + NAD(+)"}
{"X":27516,"RHEA_ID":35373,"compounds":"(beta-L-Ara4N)2-(Kdo)2-lipid A + 2 di-trans,octa-cis-undecaprenyl phosphate => 2 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A"}
{"X":27517,"RHEA_ID":24772,"DIRECTION":"UN","MASTER_ID":24772,"ec":"1.1.1.294","compounds":"7(1)-hydroxychlorophyllide a + NADP(+) = chlorophyllide b + H(+) + NADPH"}
{"X":27518,"RHEA_ID":35375,"compounds":"(beta-L-Ara4N)2-(Kdo)2-lipid A(in) + ATP + H2O = (beta-L-Ara4N)2-(Kdo)2-lipid A(out) + ADP + H(+) + phosphate"}
{"X":27519,"RHEA_ID":24774,"compounds":"chlorophyllide b + H(+) + NADPH => 7(1)-hydroxychlorophyllide a + NADP(+)"}
{"X":27520,"RHEA_ID":35377,"compounds":"(beta-L-Ara4N)2-(Kdo)2-lipid A(out) + ADP + H(+) + phosphate => (beta-L-Ara4N)2-(Kdo)2-lipid A(in) + ATP + H2O"}
{"X":27521,"RHEA_ID":24776,"compounds":"H2O + pheophorbide a = C-13(2)-carboxypyropheophorbide a + methanol"}
{"X":27522,"RHEA_ID":24777,"DIRECTION":"LR","MASTER_ID":24776,"metacyc":"RXN-13938","compounds":"H2O + pheophorbide a => C-13(2)-carboxypyropheophorbide a + methanol"}
{"X":27523,"RHEA_ID":24778,"compounds":"C-13(2)-carboxypyropheophorbide a + methanol => H2O + pheophorbide a"}
{"X":27524,"RHEA_ID":35381,"compounds":"(8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA => (6Z,9Z,12Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA"}
{"X":27525,"RHEA_ID":24780,"compounds":"C-13(2)-carboxypyropheophorbide a + H(+) = CO2 + pyropheophorbide a"}
{"X":27526,"RHEA_ID":24781,"DIRECTION":"LR","MASTER_ID":24780,"metacyc":"RXN-13939","compounds":"C-13(2)-carboxypyropheophorbide a + H(+) => CO2 + pyropheophorbide a"}
{"X":27527,"RHEA_ID":24782,"compounds":"CO2 + pyropheophorbide a => C-13(2)-carboxypyropheophorbide a + H(+)"}
{"X":27528,"RHEA_ID":35385,"compounds":"CO2 + H(+) + precorrin-7 + S-adenosyl-L-homocysteine => precorrin-6B + S-adenosyl-L-methionine"}
{"X":27529,"RHEA_ID":24785,"DIRECTION":"UN","MASTER_ID":24785,"ec":"1.14.13.127","compounds":"3-(3-hydroxyphenyl)propanoate + H(+) + NADH + O2 = 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+)"}
{"X":27530,"RHEA_ID":35387,"compounds":"precorrin-7 + S-adenosyl-L-methionine = 2 H(+) + precorrin-8X + S-adenosyl-L-homocysteine"}
{"X":27531,"RHEA_ID":24787,"compounds":"3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+) => 3-(3-hydroxyphenyl)propanoate + H(+) + NADH + O2"}
{"X":27532,"RHEA_ID":35389,"compounds":"2 H(+) + precorrin-8X + S-adenosyl-L-homocysteine => precorrin-7 + S-adenosyl-L-methionine"}
{"X":27533,"RHEA_ID":24789,"compounds":"(2E,4Z)-2-hydroxy-6-oxononadienedioate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + H(+) + succinate"}
{"X":27534,"RHEA_ID":35391,"compounds":"(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + H(+) + malonyl-CoA = (8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + CO2 + CoA"}
{"X":27535,"RHEA_ID":24791,"compounds":"(2E)-2-hydroxypenta-2,4-dienoate + H(+) + succinate => (2E,4Z)-2-hydroxy-6-oxononadienedioate + H2O"}
{"X":27536,"RHEA_ID":35393,"compounds":"(8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + CO2 + CoA => (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + H(+) + malonyl-CoA"}
{"X":27537,"RHEA_ID":24793,"DIRECTION":"UN","MASTER_ID":24793,"ec":"4.3.2.10","compounds":"5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate"}
{"X":27538,"RHEA_ID":35399,"DIRECTION":"UN","MASTER_ID":35399,"ec":"2.3.1.213","compounds":"1-O-(trans-4-coumaroyl)-beta-D-glucose + cyanidin 3-O-(6-O-glucosyl-2-O-xylosylgalactoside) betaine = beta-D-glucose + cyanidin 3-O-[6-O-(6-O-4-hydroxycinnamoyl-beta-D-glucosyl)-2-O-beta-D-xylosyl-beta-D-galactoside] + H(+)"}
{"X":27539,"RHEA_ID":24795,"DIRECTION":"RL","MASTER_ID":24793,"ecocyc":"GLUTAMIDOTRANS-RXN","metacyc":"GLUTAMIDOTRANS-RXN","compounds":"5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate => 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine"}
{"X":27540,"RHEA_ID":35401,"compounds":"beta-D-glucose + cyanidin 3-O-[6-O-(6-O-4-hydroxycinnamoyl-beta-D-glucosyl)-2-O-beta-D-xylosyl-beta-D-galactoside] + H(+) => 1-O-(trans-4-coumaroyl)-beta-D-glucose + cyanidin 3-O-(6-O-glucosyl-2-O-xylosylgalactoside) betaine"}
{"X":27541,"RHEA_ID":24797,"compounds":"(S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O = (S)-2-amino-6-oxoheptanedioate"}
{"X":27542,"RHEA_ID":35403,"DIRECTION":"UN","MASTER_ID":35403,"ec":"1.1.1.348","compounds":"(3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol + NADP(+) = (3R)-vestitone + H(+) + NADPH"}
{"X":27543,"RHEA_ID":24799,"compounds":"(S)-2-amino-6-oxoheptanedioate => (S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O"}
{"X":27544,"RHEA_ID":35405,"DIRECTION":"RL","MASTER_ID":35403,"metacyc":"RXN-3601","compounds":"(3R)-vestitone + H(+) + NADPH => (3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol + NADP(+)"}
{"X":27545,"RHEA_ID":24801,"DIRECTION":"UN","MASTER_ID":24801,"ec":"2.6.1.42","compounds":"2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate"}
{"X":27546,"RHEA_ID":35407,"compounds":"H2O + medicarpin = 4'-methoxyisoflavan-2',4,7-triol"}
{"X":27547,"RHEA_ID":24803,"compounds":"(S)-3-methyl-2-oxopentanoate + L-glutamate => 2-oxoglutarate + L-isoleucine"}
{"X":27548,"RHEA_ID":35409,"compounds":"4'-methoxyisoflavan-2',4,7-triol => H2O + medicarpin"}
{"X":27549,"RHEA_ID":24805,"compounds":"(2S)-2-acetolactate + thiamine diphosphate = 2-(1-hydroxyethyl)thiamine diphosphate + pyruvate"}
{"X":27550,"RHEA_ID":24806,"compounds":"(2S)-2-acetolactate + thiamine diphosphate => 2-(1-hydroxyethyl)thiamine diphosphate + pyruvate"}
{"X":27551,"RHEA_ID":24807,"compounds":"2-(1-hydroxyethyl)thiamine diphosphate + pyruvate => (2S)-2-acetolactate + thiamine diphosphate"}
{"X":27552,"RHEA_ID":35413,"compounds":"an anthocyanidin 3-O-[6-O-(4-hydroxycinnamoyl)-beta-D--glucoside] + CoA + H(+) => (E)-4-coumaroyl-CoA + an anthocyanidin 3-O-beta-D-glucoside"}
{"X":27553,"RHEA_ID":24809,"DIRECTION":"UN","MASTER_ID":24809,"ec":"4.2.1.9","compounds":"(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O"}
{"X":27554,"RHEA_ID":35415,"DIRECTION":"UN","MASTER_ID":35415,"ec":"2.4.1.295","compounds":"an anthocyanidin 3-O-beta-D-sambubioside + UDP-alpha-D-glucose = an anthocyanidin 5-O-beta-D-glucoside 3-O-beta-D-sambubioside + H(+) + UDP"}
{"X":27555,"RHEA_ID":24811,"compounds":"3-methyl-2-oxobutanoate + H2O => (2R)-2,3-dihydroxy-3-methylbutanoate"}
{"X":27556,"RHEA_ID":35417,"compounds":"an anthocyanidin 5-O-beta-D-glucoside 3-O-beta-D-sambubioside + H(+) + UDP => an anthocyanidin 3-O-beta-D-sambubioside + UDP-alpha-D-glucose"}
{"X":27557,"RHEA_ID":24813,"DIRECTION":"UN","MASTER_ID":24813,"ec":"2.6.1.42","compounds":"2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate"}
{"X":27558,"RHEA_ID":35419,"DIRECTION":"UN","MASTER_ID":35419,"ec":"2.4.1.297","compounds":"an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose = an anthocyanidin 3-O-sophoroside + 2 H(+) + UDP"}
{"X":27559,"RHEA_ID":24815,"compounds":"3-methyl-2-oxobutanoate + L-glutamate => 2-oxoglutarate + L-valine"}
{"X":27560,"RHEA_ID":35421,"compounds":"an anthocyanidin 3-O-sophoroside + 2 H(+) + UDP => an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose"}
{"X":27561,"RHEA_ID":24825,"DIRECTION":"UN","MASTER_ID":24825,"ec":"1.17.7.4","compounds":"dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":27562,"RHEA_ID":35423,"DIRECTION":"UN","MASTER_ID":35423,"ec":"2.4.1.298","compounds":"an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose = an anthocyanidin 3,5-di-O-beta-D-glucoside + 2 H(+) + UDP"}
{"X":27563,"RHEA_ID":24827,"DIRECTION":"RL","MASTER_ID":24825,"ecocyc":"RXN0-884","metacyc":"RXN0-884","compounds":"(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":27564,"RHEA_ID":35425,"compounds":"an anthocyanidin 3,5-di-O-beta-D-glucoside + 2 H(+) + UDP => an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose"}
{"X":27565,"RHEA_ID":24829,"compounds":"ATP + formate + N(1)-(5-phospho-D-ribosyl)glycinamide = ADP + H(+) + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + phosphate"}
{"X":27566,"RHEA_ID":24830,"DIRECTION":"LR","MASTER_ID":24829,"ecocyc":"GARTRANSFORMYL2-RXN","metacyc":"GARTRANSFORMYL2-RXN","compounds":"ATP + formate + N(1)-(5-phospho-D-ribosyl)glycinamide => ADP + H(+) + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + phosphate"}
{"X":27567,"RHEA_ID":35428,"DIRECTION":"LR","MASTER_ID":35427,"metacyc":"RXN-13967","compounds":"1-O-(trans-sinapoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside => cyanidin 3,5-di-O-beta-D-glucoside + trans-sinapate"}
{"X":27568,"RHEA_ID":35429,"compounds":"cyanidin 3,5-di-O-beta-D-glucoside + trans-sinapate => 1-O-(trans-sinapoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside"}
{"X":27569,"RHEA_ID":24836,"DIRECTION":"UN","MASTER_ID":24836,"ec":"6.3.4.23","compounds":"5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + ATP + formate = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + ADP + phosphate"}
{"X":27570,"RHEA_ID":24837,"compounds":"5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + ATP + formate => 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + ADP + phosphate"}
{"X":27571,"RHEA_ID":35432,"DIRECTION":"LR","MASTER_ID":35431,"metacyc":"RXN-13969","compounds":"1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside => 4-hydroxy-3-methoxybenzoate + cyanidin 3,7-di-O-beta-D-glucoside"}
{"X":27572,"RHEA_ID":35433,"compounds":"4-hydroxy-3-methoxybenzoate + cyanidin 3,7-di-O-beta-D-glucoside => 1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside"}
{"X":27573,"RHEA_ID":24840,"DIRECTION":"UN","MASTER_ID":24840,"ec":"4.1.99.17","compounds":"5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine"}
{"X":27574,"RHEA_ID":24841,"DIRECTION":"LR","MASTER_ID":24840,"ecocyc":"PYRIMSYN1-RXN","metacyc":"PYRIMSYN1-RXN","compounds":"5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine => 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine"}
{"X":27575,"RHEA_ID":35436,"DIRECTION":"LR","MASTER_ID":35435,"metacyc":"RXN-13974","compounds":"cyanidin 3-O-beta-D-galactoside + UDP-alpha-D-xylose => cyanidin 3-O-[beta-D-xylosyl-(1->2)-beta-D-galactoside] + H(+) + UDP"}
{"X":27576,"RHEA_ID":35437,"compounds":"cyanidin 3-O-[beta-D-xylosyl-(1->2)-beta-D-galactoside] + H(+) + UDP => cyanidin 3-O-beta-D-galactoside + UDP-alpha-D-xylose"}
{"X":27577,"RHEA_ID":24844,"DIRECTION":"UN","MASTER_ID":24844,"ec":"3.2.1.204","compounds":"cyclobis-(1->3)-alpha-isomaltosyl + 2 H2O = 2 isomaltose"}
{"X":27578,"RHEA_ID":24845,"DIRECTION":"LR","MASTER_ID":24844,"metacyc":"RXN-18150","compounds":"cyclobis-(1->3)-alpha-isomaltosyl + 2 H2O => 2 isomaltose"}
{"X":27579,"RHEA_ID":35440,"DIRECTION":"LR","MASTER_ID":35439,"metacyc":"RXN-9996","compounds":"CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol + L-serine => archaetidylserine + CMP + H(+)"}
{"X":27580,"RHEA_ID":35441,"compounds":"archaetidylserine + CMP + H(+) => CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol + L-serine"}
{"X":27581,"RHEA_ID":24848,"DIRECTION":"UN","MASTER_ID":24848,"ec":"4.2.1.118","compounds":"3-dehydroshikimate = 3,4-dihydroxybenzoate + H2O"}
{"X":27582,"RHEA_ID":24849,"DIRECTION":"LR","MASTER_ID":24848,"metacyc":"DHSHIKIMATE-DEHYDRO-RXN","compounds":"3-dehydroshikimate => 3,4-dihydroxybenzoate + H2O"}
{"X":27583,"RHEA_ID":35444,"compounds":"an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-xylose => an anthocyanidin 3-O-beta-D-sambubioside + 2 H(+) + UDP"}
{"X":27584,"RHEA_ID":35445,"compounds":"an anthocyanidin 3-O-beta-D-sambubioside + 2 H(+) + UDP => an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-xylose"}
{"X":27585,"RHEA_ID":24861,"DIRECTION":"UN","MASTER_ID":24861,"ec":"2.4.1.116","compounds":"pelargonidin 3-O-rutinoside + UDP-alpha-D-glucose = H(+) + pelargonidin 3-O-rutinoside 5-O-beta-D-glucoside + UDP"}
{"X":27586,"RHEA_ID":24862,"DIRECTION":"LR","MASTER_ID":24861,"metacyc":"RXN-7832","compounds":"pelargonidin 3-O-rutinoside + UDP-alpha-D-glucose => H(+) + pelargonidin 3-O-rutinoside 5-O-beta-D-glucoside + UDP"}
{"X":27587,"RHEA_ID":35448,"compounds":"(1'S)-averantin + NADP(+) => H(+) + NADPH + norsolorinic acid"}
{"X":27588,"RHEA_ID":35449,"compounds":"H(+) + NADPH + norsolorinic acid => (1'S)-averantin + NADP(+)"}
{"X":27589,"RHEA_ID":24865,"DIRECTION":"UN","MASTER_ID":24865,"ec":"1.14.11.20","compounds":"(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + 2-oxoglutarate + O2 = 4-O-deacetyl-16-O-demethylvindoline + CO2 + succinate"}
{"X":27590,"RHEA_ID":24866,"compounds":"(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + 2-oxoglutarate + O2 => 4-O-deacetyl-16-O-demethylvindoline + CO2 + succinate"}
{"X":27591,"RHEA_ID":35456,"compounds":"5alpha-cholest-7-en-3-one + 2 H(+) + 3 NADPH + 3 O2 => (25S)-Delta7-dafachronate + 4 H2O + 3 NADP(+)"}
{"X":27592,"RHEA_ID":24868,"compounds":"(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + 2-oxoglutarate + O2 <=> 4-O-deacetyl-16-O-demethylvindoline + CO2 + succinate"}
{"X":27593,"RHEA_ID":24869,"DIRECTION":"UN","MASTER_ID":24869,"ec":"2.4.2.28","compounds":"5'-deoxyadenosine + phosphate = 5-deoxy-alpha-D-ribose 1-phosphate + adenine"}
{"X":27594,"RHEA_ID":24870,"DIRECTION":"LR","MASTER_ID":24869,"metacyc":"RXN-14304","compounds":"5'-deoxyadenosine + phosphate => 5-deoxy-alpha-D-ribose 1-phosphate + adenine"}
{"X":27595,"RHEA_ID":35460,"compounds":"cholesterol + NAD(+) => cholest-5-en-3-one + H(+) + NADH"}
{"X":27596,"RHEA_ID":24872,"compounds":"5'-deoxyadenosine + phosphate <=> 5-deoxy-alpha-D-ribose 1-phosphate + adenine"}
{"X":27597,"RHEA_ID":24873,"DIRECTION":"UN","MASTER_ID":24873,"ec":"3.1.3.3","compounds":"H2O + O-phospho-D-serine = D-serine + phosphate"}
{"X":27598,"RHEA_ID":24874,"DIRECTION":"LR","MASTER_ID":24873,"metacyc":"PSERPHOSPHA-RXN","compounds":"H2O + O-phospho-D-serine => D-serine + phosphate"}
{"X":27599,"RHEA_ID":24875,"compounds":"D-serine + phosphate => H2O + O-phospho-D-serine"}
{"X":27600,"RHEA_ID":35465,"compounds":"5alpha-cholest-7-en-3-one + H(+) + NADH => 5alpha-cholest-7-en-3beta-ol + NAD(+)"}
{"X":27601,"RHEA_ID":24878,"DIRECTION":"UN","MASTER_ID":24878,"ec":"1.1.99.32","compounds":"A + L-sorbopyranose = 1-dehydro-L-sorbose + AH2"}
{"X":27602,"RHEA_ID":24879,"DIRECTION":"LR","MASTER_ID":24878,"metacyc":"RXN-8782","compounds":"A + L-sorbopyranose => 1-dehydro-L-sorbose + AH2"}
{"X":27603,"RHEA_ID":24880,"compounds":"1-dehydro-L-sorbose + AH2 => A + L-sorbopyranose"}
{"X":27604,"RHEA_ID":35469,"compounds":"(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-(methylsulfanyl)propanoate + H(+) => (6S)-5,6,7,8-tetrahydrofolate + S,S-dimethyl-beta-propiothetin"}
{"X":27605,"RHEA_ID":24882,"DIRECTION":"UN","MASTER_ID":24882,"ec":"1.2.1.88","compounds":"(S)-1-pyrroline-5-carboxylate + 2 H2O + NADP(+) = H(+) + L-glutamate + NADPH"}
{"X":27606,"RHEA_ID":24883,"compounds":"(S)-1-pyrroline-5-carboxylate + 2 H2O + NADP(+) => H(+) + L-glutamate + NADPH"}
{"X":27607,"RHEA_ID":35472,"DIRECTION":"LR","MASTER_ID":35471,"metacyc":"RXN-4002","compounds":"(+)-6a-hydroxymaackiain + S-adenosyl-L-methionine => (+)-pisatin + H(+) + S-adenosyl-L-homocysteine"}
{"X":27608,"RHEA_ID":35473,"compounds":"(+)-pisatin + H(+) + S-adenosyl-L-homocysteine => (+)-6a-hydroxymaackiain + S-adenosyl-L-methionine"}
{"X":27609,"RHEA_ID":24886,"DIRECTION":"UN","MASTER_ID":24886,"ec":"1.2.1.88","compounds":"(R)-1-pyrroline-5-carboxylate + 2 H2O + NAD(+) = D-glutamate + H(+) + NADH"}
{"X":27610,"RHEA_ID":24887,"compounds":"(R)-1-pyrroline-5-carboxylate + 2 H2O + NAD(+) => D-glutamate + H(+) + NADH"}
{"X":27611,"RHEA_ID":35476,"DIRECTION":"LR","MASTER_ID":35475,"metacyc":"RXN-9483","compounds":"(1'S,5'S)-5'-hydroxyaverantin + NAD(+) => (S)-5'-oxoaverantin + H(+) + NADH"}
{"X":27612,"RHEA_ID":24889,"compounds":"(R)-1-pyrroline-5-carboxylate + 2 H2O + NAD(+) <=> D-glutamate + H(+) + NADH"}
{"X":27613,"RHEA_ID":24890,"DIRECTION":"UN","MASTER_ID":24890,"ec":"1.2.1.88","compounds":"1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NAD(+) = 4-hydroxy-L-glutamate + H(+) + NADH"}
{"X":27614,"RHEA_ID":24891,"DIRECTION":"LR","MASTER_ID":24890,"metacyc":"HYDROXYPYRROLINEDEH-RXN","compounds":"1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NAD(+) => 4-hydroxy-L-glutamate + H(+) + NADH"}
{"X":27615,"RHEA_ID":35480,"DIRECTION":"LR","MASTER_ID":35479,"metacyc":"RXN-9484","compounds":"(1'S,5'R)-5'-hydroxyaverantin + NAD(+) => (S)-5'-oxoaverantin + 2 H(+) + NADH"}
{"X":27616,"RHEA_ID":35481,"compounds":"(S)-5'-oxoaverantin + 2 H(+) + NADH => (1'S,5'R)-5'-hydroxyaverantin + NAD(+)"}
{"X":27617,"RHEA_ID":24894,"DIRECTION":"UN","MASTER_ID":24894,"ec":"2.1.1.69","compounds":"5-hydroxyxanthotoxin + S-adenosyl-L-methionine = isopimpinellin + S-adenosyl-L-homocysteine"}
{"X":27618,"RHEA_ID":24895,"DIRECTION":"LR","MASTER_ID":24894,"metacyc":"RXN-14041","compounds":"5-hydroxyxanthotoxin + S-adenosyl-L-methionine => isopimpinellin + S-adenosyl-L-homocysteine"}
{"X":27619,"RHEA_ID":35484,"compounds":"5alpha-cholest-7-en-3-one + S-adenosyl-L-methionine => 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + S-adenosyl-L-homocysteine"}
{"X":27620,"RHEA_ID":35485,"compounds":"4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + S-adenosyl-L-homocysteine => 5alpha-cholest-7-en-3-one + S-adenosyl-L-methionine"}
{"X":27621,"RHEA_ID":24898,"DIRECTION":"UN","MASTER_ID":24898,"ec":"2.7.7.65","compounds":"2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate"}
{"X":27622,"RHEA_ID":24899,"DIRECTION":"LR","MASTER_ID":24898,"ecocyc":"GTP-CYCLOHYDRO-II-RXN","metacyc":"GTP-CYCLOHYDRO-II-RXN","compounds":"2 GTP => cyclic di-3',5'-guanylate + 2 diphosphate"}
{"X":27623,"RHEA_ID":35488,"DIRECTION":"LR","MASTER_ID":35487,"metacyc":"RXN-1541","compounds":"(S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-2,3-dihydrogenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":27624,"RHEA_ID":35489,"compounds":"2-hydroxy-2,3-dihydrogenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":27625,"RHEA_ID":24902,"DIRECTION":"UN","MASTER_ID":24902,"ec":"3.1.4.52","compounds":"cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H(+)"}
{"X":27626,"RHEA_ID":24903,"DIRECTION":"LR","MASTER_ID":24902,"ecocyc":"RXN0-4181","metacyc":"RXN0-4181","compounds":"cyclic di-3',5'-guanylate + H2O => 5'-phosphoguanylyl(3'->5')guanosine + H(+)"}
{"X":27627,"RHEA_ID":35496,"DIRECTION":"LR","MASTER_ID":35495,"ecocyc":"RXN0-5040","metacyc":"RXN0-5040","compounds":"H2O + N-(4-aminobenzoyl)-L-glutamate => 4-aminobenzoate + L-glutamate"}
{"X":27628,"RHEA_ID":35497,"compounds":"4-aminobenzoate + L-glutamate => H2O + N-(4-aminobenzoyl)-L-glutamate"}
{"X":27629,"RHEA_ID":24906,"DIRECTION":"UN","MASTER_ID":24906,"ec":"4.3.1.23","compounds":"L-tyrosine = NH4(+) + trans-4-coumarate"}
{"X":27630,"RHEA_ID":24906,"DIRECTION":"UN","MASTER_ID":24906,"ec":"4.3.1.25","compounds":"L-tyrosine = NH4(+) + trans-4-coumarate"}
{"X":27631,"RHEA_ID":24907,"DIRECTION":"LR","MASTER_ID":24906,"metacyc":"RXN-9697","compounds":"L-tyrosine => NH4(+) + trans-4-coumarate"}
{"X":27632,"RHEA_ID":24908,"compounds":"NH4(+) + trans-4-coumarate => L-tyrosine"}
{"X":27633,"RHEA_ID":45431,"compounds":"H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine <=> H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + sn-glycerol 3-phosphate"}
{"X":27634,"RHEA_ID":24910,"compounds":"L,L-cystathionine = 2-aminobut-2-enoate + L-cysteine"}
{"X":27635,"RHEA_ID":24911,"DIRECTION":"LR","MASTER_ID":24910,"metacyc":"RXN-14301","compounds":"L,L-cystathionine => 2-aminobut-2-enoate + L-cysteine"}
{"X":27636,"RHEA_ID":24912,"compounds":"2-aminobut-2-enoate + L-cysteine => L,L-cystathionine"}
{"X":27637,"RHEA_ID":55425,"DIRECTION":"LR","MASTER_ID":55424,"metacyc":"RXN-11911","compounds":"(3S,6E)-nerolidol + O2 + reduced [NADPH--hemoprotein reductase] => (3E)-4,8-dimethylnona-1,3,7-triene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":27638,"RHEA_ID":24919,"compounds":"L-homoserine = 2-aminobut-2-enoate + H2O"}
{"X":27639,"RHEA_ID":24920,"DIRECTION":"LR","MASTER_ID":24919,"metacyc":"RXN-14049","compounds":"L-homoserine => 2-aminobut-2-enoate + H2O"}
{"X":27640,"RHEA_ID":24921,"compounds":"2-aminobut-2-enoate + H2O => L-homoserine"}
{"X":27641,"RHEA_ID":45439,"compounds":"H2O + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> H(+) + N-hexadecanoylethanolamine + sn-glycerol 3-phosphate"}
{"X":27642,"RHEA_ID":24923,"DIRECTION":"UN","MASTER_ID":24923,"ec":"4.4.1.1","compounds":"L-homoserine = 2-oxobutanoate + NH4(+)"}
{"X":27643,"RHEA_ID":24924,"DIRECTION":"LR","MASTER_ID":24923,"metacyc":"HOMOSERDEAM-RXN","compounds":"L-homoserine => 2-oxobutanoate + NH4(+)"}
{"X":27644,"RHEA_ID":24925,"compounds":"2-oxobutanoate + NH4(+) => L-homoserine"}
{"X":27645,"RHEA_ID":24926,"compounds":"L-homoserine <=> 2-oxobutanoate + NH4(+)"}
{"X":27646,"RHEA_ID":24927,"DIRECTION":"UN","MASTER_ID":24927,"ec":"4.4.1.35","compounds":"H2O + L-cystine = NH4(+) + pyruvate + S-sulfanyl-L-cysteine"}
{"X":27647,"RHEA_ID":24928,"DIRECTION":"LR","MASTER_ID":24927,"metacyc":"CYSTHIOCYS-RXN","compounds":"H2O + L-cystine => NH4(+) + pyruvate + S-sulfanyl-L-cysteine"}
{"X":27648,"RHEA_ID":24929,"compounds":"NH4(+) + pyruvate + S-sulfanyl-L-cysteine => H2O + L-cystine"}
{"X":27649,"RHEA_ID":45447,"compounds":"H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-sn-glycero-3-phosphoethanolamine <=> H(+) + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl ethanolamine + sn-glycerol 3-phosphate"}
{"X":27650,"RHEA_ID":24931,"DIRECTION":"UN","MASTER_ID":24931,"ec":"4.4.1.1","compounds":"H2O + L-cysteine = H(+) + hydrogen sulfide + NH4(+) + pyruvate"}
{"X":27651,"RHEA_ID":24931,"DIRECTION":"UN","MASTER_ID":24931,"ec":"4.4.1.28","compounds":"H2O + L-cysteine = H(+) + hydrogen sulfide + NH4(+) + pyruvate"}
{"X":27652,"RHEA_ID":24932,"DIRECTION":"LR","MASTER_ID":24931,"ecocyc":"LCYSDESULF-RXN","metacyc":"LCYSDESULF-RXN","compounds":"H2O + L-cysteine => H(+) + hydrogen sulfide + NH4(+) + pyruvate"}
{"X":27653,"RHEA_ID":24933,"compounds":"H(+) + hydrogen sulfide + NH4(+) + pyruvate => H2O + L-cysteine"}
{"X":27654,"RHEA_ID":35523,"compounds":"H(+) + N-ethylmaleimide + NADPH = N-ethylsuccinimide + NADP(+)"}
{"X":27655,"RHEA_ID":24935,"compounds":"H2O + imidazol-4-one = N-formimidoylglycine"}
{"X":27656,"RHEA_ID":24936,"DIRECTION":"LR","MASTER_ID":24935,"metacyc":"R63-RXN","compounds":"H2O + imidazol-4-one => N-formimidoylglycine"}
{"X":27657,"RHEA_ID":24937,"compounds":"N-formimidoylglycine => H2O + imidazol-4-one"}
{"X":27658,"RHEA_ID":35527,"compounds":"H(+) + N-ethylmaleimide + NADH = N-ethylsuccinimide + NAD(+)"}
{"X":27659,"RHEA_ID":24939,"DIRECTION":"UN","MASTER_ID":24939,"ec":"1.2.1.88","compounds":"(R)-1-pyrroline-5-carboxylate + 2 H2O + NADP(+) = D-glutamate + H(+) + NADPH"}
{"X":27660,"RHEA_ID":24940,"compounds":"(R)-1-pyrroline-5-carboxylate + 2 H2O + NADP(+) => D-glutamate + H(+) + NADPH"}
{"X":27661,"RHEA_ID":24941,"compounds":"D-glutamate + H(+) + NADPH => (R)-1-pyrroline-5-carboxylate + 2 H2O + NADP(+)"}
{"X":27662,"RHEA_ID":35531,"DIRECTION":"UN","MASTER_ID":35531,"ec":"1.3.3.13","compounds":"cyclo(L-phenylalanyl-L-leucyl) + 2 O2 = albonoursin + 2 H2O2"}
{"X":27663,"RHEA_ID":24943,"DIRECTION":"UN","MASTER_ID":24943,"ec":"1.2.1.88","compounds":"1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NADP(+) = 4-hydroxy-L-glutamate + H(+) + NADPH"}
{"X":27664,"RHEA_ID":24944,"compounds":"1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NADP(+) => 4-hydroxy-L-glutamate + H(+) + NADPH"}
{"X":27665,"RHEA_ID":24945,"compounds":"4-hydroxy-L-glutamate + H(+) + NADPH => 1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NADP(+)"}
{"X":27666,"RHEA_ID":35535,"compounds":"cyclo(L-phenylalanyl-L-leucyl) + O2 = cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + H2O2"}
{"X":27667,"RHEA_ID":24948,"DIRECTION":"UN","MASTER_ID":24948,"ec":"2.8.3.13","compounds":"3-hydroxy-3-methylglutarate + malonyl-CoA = (3S)-hydroxy-3-methylglutaryl-CoA + malonate"}
{"X":27668,"RHEA_ID":24949,"compounds":"3-hydroxy-3-methylglutarate + malonyl-CoA => (3S)-hydroxy-3-methylglutaryl-CoA + malonate"}
{"X":27669,"RHEA_ID":24950,"compounds":"(3S)-hydroxy-3-methylglutaryl-CoA + malonate => 3-hydroxy-3-methylglutarate + malonyl-CoA"}
{"X":27670,"RHEA_ID":35539,"compounds":"cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + O2 = albonoursin + H2O2"}
{"X":27671,"RHEA_ID":24952,"DIRECTION":"UN","MASTER_ID":24952,"ec":"2.7.1.170","compounds":"1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O = ADP + H(+) + N-acetyl-D-muramate 6-phosphate"}
{"X":27672,"RHEA_ID":24953,"DIRECTION":"LR","MASTER_ID":24952,"ecocyc":"RXN0-4621","metacyc":"RXN0-4621","compounds":"1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O => ADP + H(+) + N-acetyl-D-muramate 6-phosphate"}
{"X":27673,"RHEA_ID":24954,"compounds":"ADP + H(+) + N-acetyl-D-muramate 6-phosphate => 1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O"}
{"X":27674,"RHEA_ID":24955,"compounds":"1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O <=> ADP + H(+) + N-acetyl-D-muramate 6-phosphate"}
{"X":27675,"RHEA_ID":24956,"compounds":"H2O + N-acetyl-beta-D-muramate 6-phosphate = (R)-lactate + N-acetyl-beta-D-glucosamine 6-phosphate"}
{"X":27676,"RHEA_ID":24957,"compounds":"H2O + N-acetyl-beta-D-muramate 6-phosphate => (R)-lactate + N-acetyl-beta-D-glucosamine 6-phosphate"}
{"X":27677,"RHEA_ID":24958,"compounds":"(R)-lactate + N-acetyl-beta-D-glucosamine 6-phosphate => H2O + N-acetyl-beta-D-muramate 6-phosphate"}
{"X":27678,"RHEA_ID":24959,"compounds":"H2O + N-acetyl-beta-D-muramate 6-phosphate <=> (R)-lactate + N-acetyl-beta-D-glucosamine 6-phosphate"}
{"X":27679,"RHEA_ID":24960,"DIRECTION":"UN","MASTER_ID":24960,"ec":"1.13.12.24","compounds":"apo-[aequorin] + 3 Ca(2+) + coelenterazine + O2 = [excited state blue fluorescent protein] + CO2"}
{"X":27680,"RHEA_ID":24961,"compounds":"apo-[aequorin] + 3 Ca(2+) + coelenterazine + O2 => [excited state blue fluorescent protein] + CO2"}
{"X":27681,"RHEA_ID":24962,"compounds":"[excited state blue fluorescent protein] + CO2 => apo-[aequorin] + 3 Ca(2+) + coelenterazine + O2"}
{"X":27682,"RHEA_ID":24963,"compounds":"apo-[aequorin] + 3 Ca(2+) + coelenterazine + O2 <=> [excited state blue fluorescent protein] + CO2"}
{"X":27683,"RHEA_ID":35556,"DIRECTION":"LR","MASTER_ID":35555,"metacyc":"RXN-14312","compounds":"cyclo(L-leucyl-L-leucyl) + 4 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] + pulcherriminic acid"}
{"X":27684,"RHEA_ID":35557,"compounds":"4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] + pulcherriminic acid => cyclo(L-leucyl-L-leucyl) + 4 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]"}
{"X":27685,"RHEA_ID":24966,"compounds":"calcitetrol + H2O + 2 oxidized [adrenodoxin] => calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}
{"X":27686,"RHEA_ID":35559,"compounds":"H(+) + menaquinone-7 + NADH = menaquinol-7 + NAD(+)"}
{"X":27687,"RHEA_ID":24968,"DIRECTION":"UN","MASTER_ID":24968,"ec":"1.14.15.16","compounds":"calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = H2O + 2 oxidized [adrenodoxin] + secalciferol"}
{"X":27688,"RHEA_ID":35561,"compounds":"menaquinol-7 + NAD(+) => H(+) + menaquinone-7 + NADH"}
{"X":27689,"RHEA_ID":24970,"compounds":"H2O + 2 oxidized [adrenodoxin] + secalciferol => calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}
{"X":27690,"RHEA_ID":35563,"compounds":"H2O + N-(9Z-hexadecenoyl) ethanolamine = (9Z)-hexadecenoate + ethanolamine"}
{"X":27691,"RHEA_ID":24972,"DIRECTION":"UN","MASTER_ID":24972,"ec":"1.14.15.16","compounds":"calcitetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (1S)-1,25-dihydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin]"}
{"X":27692,"RHEA_ID":35565,"compounds":"(9Z)-hexadecenoate + ethanolamine => H2O + N-(9Z-hexadecenoyl) ethanolamine"}
{"X":27693,"RHEA_ID":24974,"compounds":"(1S)-1,25-dihydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin] => calcitetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}
{"X":27694,"RHEA_ID":24975,"compounds":"calcitetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (1S)-1,25-dihydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin]"}
{"X":27695,"RHEA_ID":24976,"DIRECTION":"UN","MASTER_ID":24976,"ec":"1.14.15.16","compounds":"(1S)-1,25-dihydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (1S)-1,23,25-trihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin]"}
{"X":27696,"RHEA_ID":35569,"compounds":"(9Z,12Z)-octadecadienoate + ethanolamine => H2O + linoleoyl ethanolamide"}
{"X":27697,"RHEA_ID":24978,"compounds":"(1S)-1,23,25-trihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin] => (1S)-1,25-dihydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}
{"X":27698,"RHEA_ID":24979,"compounds":"(1S)-1,25-dihydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (1S)-1,23,25-trihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin]"}
{"X":27699,"RHEA_ID":24980,"DIRECTION":"UN","MASTER_ID":24980,"ec":"2.7.7.97","compounds":"3-hydroxy-4-methylanthranilate + ATP + H(+) = 3-hydroxy-4-methylanthranilyl-5'-AMP + diphosphate"}
{"X":27700,"RHEA_ID":35573,"compounds":"(1'S,5'S)-5'-hydroxyaverantin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":27701,"RHEA_ID":24982,"compounds":"3-hydroxy-4-methylanthranilyl-5'-AMP + diphosphate => 3-hydroxy-4-methylanthranilate + ATP + H(+)"}
{"X":27702,"RHEA_ID":35575,"DIRECTION":"UN","MASTER_ID":35575,"ec":"1.14.14.116","compounds":"(1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase] = (1'S,5'R)-5'-hydroxyaverantin + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":27703,"RHEA_ID":24984,"DIRECTION":"UN","MASTER_ID":24984,"ec":"1.14.15.16","compounds":"(1S)-1,23-dihydroxy-24,25,26,27-tetranorcalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + 2 H2O + 2 oxidized [adrenodoxin]"}
{"X":27704,"RHEA_ID":35577,"compounds":"(1'S,5'R)-5'-hydroxyaverantin + H2O + oxidized [NADPH--hemoprotein reductase] => (1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":27705,"RHEA_ID":24986,"compounds":"(1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + 2 H2O + 2 oxidized [adrenodoxin] => (1S)-1,23-dihydroxy-24,25,26,27-tetranorcalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}
{"X":27706,"RHEA_ID":24987,"compounds":"(1S)-1,23-dihydroxy-24,25,26,27-tetranorcalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + 2 H2O + 2 oxidized [adrenodoxin]"}
{"X":27707,"RHEA_ID":24988,"DIRECTION":"UN","MASTER_ID":24988,"ec":"1.14.15.16","compounds":"(1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + H(+) + O2 + 2 reduced [adrenodoxin] = calcitroate + H2O + 2 oxidized [adrenodoxin]"}
{"X":27708,"RHEA_ID":24989,"compounds":"(1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + H(+) + O2 + 2 reduced [adrenodoxin] => calcitroate + H2O + 2 oxidized [adrenodoxin]"}
{"X":27709,"RHEA_ID":24990,"compounds":"calcitroate + H2O + 2 oxidized [adrenodoxin] => (1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + H(+) + O2 + 2 reduced [adrenodoxin]"}
{"X":27710,"RHEA_ID":24991,"compounds":"(1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + H(+) + O2 + 2 reduced [adrenodoxin] <=> calcitroate + H2O + 2 oxidized [adrenodoxin]"}
{"X":27711,"RHEA_ID":24992,"compounds":"L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase]"}
{"X":27712,"RHEA_ID":35585,"compounds":"D-glyceraldehyde + pyruvate => 2-dehydro-3-deoxy-D-gluconate"}
{"X":27713,"RHEA_ID":24994,"compounds":"2 H(+) + H2O + N-hydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase] => L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":27714,"RHEA_ID":35587,"DIRECTION":"UN","MASTER_ID":35587,"ec":"3.1.3.102","compounds":"FMN + H2O = phosphate + riboflavin"}
{"X":27715,"RHEA_ID":24996,"compounds":"N-hydroxy-L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase]"}
{"X":27716,"RHEA_ID":35589,"compounds":"phosphate + riboflavin => FMN + H2O"}
{"X":27717,"RHEA_ID":24998,"compounds":"H(+) + H2O + N,N-dihydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":27718,"RHEA_ID":35591,"DIRECTION":"UN","MASTER_ID":35591,"ec":"1.12.98.4","compounds":"H2 + n sulfur = H(+) + hydrogen sulfide + (n-1) sulfur"}
{"X":27719,"RHEA_ID":25000,"compounds":"H(+) + N,N-dihydroxy-L-phenylalanine = (E)-phenylacetaldehyde oxime + CO2 + H2O"}
{"X":27720,"RHEA_ID":35593,"compounds":"H(+) + hydrogen sulfide + (n-1) sulfur => H2 + n sulfur"}
{"X":27721,"RHEA_ID":25002,"compounds":"(E)-phenylacetaldehyde oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-phenylalanine"}
{"X":27722,"RHEA_ID":35595,"DIRECTION":"UN","MASTER_ID":35595,"ec":"1.13.11.37","compounds":"benzene-1,2,4-triol + O2 = 2 H(+) + maleylacetate"}
{"X":27723,"RHEA_ID":25005,"compounds":"L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase]"}
{"X":27724,"RHEA_ID":25006,"DIRECTION":"LR","MASTER_ID":25005,"metacyc":"RXN-12061","compounds":"L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase]"}
{"X":27725,"RHEA_ID":45523,"compounds":"[phycoerythrocyanin alpha-subunit]-Cys(84)-phycoviolobilin <=> (2R,3E)-phycocyanobilin + apo-[phycoerythrocyanin alpha-subunit]"}
{"X":27726,"RHEA_ID":45524,"DIRECTION":"UN","MASTER_ID":45524,"ec":"4.4.1.32","compounds":"[C-phycocyanin alpha-subunit]-Cys(84)-phycocyanobilin = (2R,3E)-phycocyanobilin + apo-[C-phycocyanin alpha-subunit]"}
{"X":27727,"RHEA_ID":25009,"compounds":"N-hydroxy-L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase]"}
{"X":27728,"RHEA_ID":25010,"DIRECTION":"LR","MASTER_ID":25009,"metacyc":"RXN-12062","compounds":"N-hydroxy-L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase]"}
{"X":27729,"RHEA_ID":25011,"compounds":"H(+) + H2O + N,N-dihydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":27730,"RHEA_ID":35603,"compounds":"beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate"}
{"X":27731,"RHEA_ID":25013,"compounds":"H(+) + N,N-dihydroxy-L-tryptophan = (E)-(indol-3-yl)acetaldehyde oxime + CO2 + H2O"}
{"X":27732,"RHEA_ID":25014,"DIRECTION":"LR","MASTER_ID":25013,"metacyc":"RXN-12063","compounds":"H(+) + N,N-dihydroxy-L-tryptophan => (E)-(indol-3-yl)acetaldehyde oxime + CO2 + H2O"}
{"X":27733,"RHEA_ID":25015,"compounds":"(E)-(indol-3-yl)acetaldehyde oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-tryptophan"}
{"X":27734,"RHEA_ID":35607,"compounds":"acetoin + NADP(+) = diacetyl + H(+) + NADPH"}
{"X":27735,"RHEA_ID":25017,"DIRECTION":"UN","MASTER_ID":25017,"ec":"3.1.3.67","compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate"}
{"X":27736,"RHEA_ID":25018,"DIRECTION":"LR","MASTER_ID":25017,"metacyc":"3.1.3.67-RXN","compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate"}
{"X":27737,"RHEA_ID":25019,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O"}
{"X":27738,"RHEA_ID":35611,"compounds":"menadiol + 2 O2 = 2 H(+) + menadione + 2 superoxide"}
{"X":27739,"RHEA_ID":25021,"DIRECTION":"UN","MASTER_ID":25021,"ec":"2.7.1.161","compounds":"CTP + riboflavin = CDP + FMN + H(+)"}
{"X":27740,"RHEA_ID":25022,"DIRECTION":"LR","MASTER_ID":25021,"metacyc":"RXN-9296","compounds":"CTP + riboflavin => CDP + FMN + H(+)"}
{"X":27741,"RHEA_ID":25023,"compounds":"CDP + FMN + H(+) => CTP + riboflavin"}
{"X":27742,"RHEA_ID":45540,"compounds":"H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}
{"X":27743,"RHEA_ID":25025,"DIRECTION":"UN","MASTER_ID":25025,"ec":"3.5.4.31","compounds":"H(+) + H2O + S-methyl-5'-thioadenosine = NH4(+) + S-methyl-5'-thioinosine"}
{"X":27744,"RHEA_ID":25026,"compounds":"H(+) + H2O + S-methyl-5'-thioadenosine => NH4(+) + S-methyl-5'-thioinosine"}
{"X":27745,"RHEA_ID":25027,"compounds":"NH4(+) + S-methyl-5'-thioinosine => H(+) + H2O + S-methyl-5'-thioadenosine"}
{"X":27746,"RHEA_ID":35619,"compounds":"L-idarate = D-glucarate"}
{"X":27747,"RHEA_ID":25029,"DIRECTION":"UN","MASTER_ID":25029,"ec":"3.1.3.84","compounds":"ADP-D-ribose 1''-phosphate + H2O = ADP-D-ribose + phosphate"}
{"X":27748,"RHEA_ID":25030,"DIRECTION":"LR","MASTER_ID":25029,"metacyc":"RXN-10034","compounds":"ADP-D-ribose 1''-phosphate + H2O => ADP-D-ribose + phosphate"}
{"X":27749,"RHEA_ID":25031,"compounds":"ADP-D-ribose + phosphate => ADP-D-ribose 1''-phosphate + H2O"}
{"X":27750,"RHEA_ID":35623,"DIRECTION":"UN","MASTER_ID":35623,"ec":"2.3.2.1","metacyc":"D-GLUTAMYLTRANSFERASE-RXN","compounds":"D-glutamate + D-glutamine = D-gamma-glutamyl-D-glutamate + NH4(+)"}
{"X":27751,"RHEA_ID":25033,"DIRECTION":"UN","MASTER_ID":25033,"ec":"1.1.1.300","compounds":"all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH"}
{"X":27752,"RHEA_ID":25034,"compounds":"all-trans-retinol + NADP(+) => all-trans-retinal + H(+) + NADPH"}
{"X":27753,"RHEA_ID":25035,"DIRECTION":"RL","MASTER_ID":25033,"reactome":"R-HSA-2464822.1","compounds":"all-trans-retinal + H(+) + NADPH => all-trans-retinol + NADP(+)"}
{"X":27754,"RHEA_ID":35627,"DIRECTION":"UN","MASTER_ID":35627,"ec":"2.4.1.238","compounds":"delphinidin 3,5-bis-O-beta-D-glucoside + UDP-alpha-D-glucose = delphinidin 3,3',5-tri-O-beta-D-glucoside + H(+) + UDP"}
{"X":27755,"RHEA_ID":25035,"DIRECTION":"RL","MASTER_ID":25033,"reactome":"R-HSA-5623643.1","compounds":"all-trans-retinal + H(+) + NADPH => all-trans-retinol + NADP(+)"}
{"X":27756,"RHEA_ID":25035,"DIRECTION":"RL","MASTER_ID":25033,"reactome":"R-HSA-2464803.2","compounds":"all-trans-retinal + H(+) + NADPH => all-trans-retinol + NADP(+)"}
{"X":27757,"RHEA_ID":25035,"DIRECTION":"RL","MASTER_ID":25033,"reactome":"R-HSA-5419165.1","compounds":"all-trans-retinal + H(+) + NADPH => all-trans-retinol + NADP(+)"}
{"X":27758,"RHEA_ID":25035,"DIRECTION":"RL","MASTER_ID":25033,"reactome":"R-HSA-5615668.1","compounds":"all-trans-retinal + H(+) + NADPH => all-trans-retinol + NADP(+)"}
{"X":27759,"RHEA_ID":35632,"DIRECTION":"LR","MASTER_ID":35631,"metacyc":"RXN-13960","compounds":"cyanidin + UDP-alpha-D-galactose => cyanidin 3-O-beta-D-galactoside + H(+) + UDP"}
{"X":27760,"RHEA_ID":25037,"DIRECTION":"UN","MASTER_ID":25037,"ec":"2.7.1.164","compounds":"ATP + L-seryl-tRNA(Sec) = ADP + O-phospho-L-seryl-tRNA(Sec)"}
{"X":27761,"RHEA_ID":25038,"compounds":"ATP + L-seryl-tRNA(Sec) => ADP + O-phospho-L-seryl-tRNA(Sec)"}
{"X":27762,"RHEA_ID":35635,"DIRECTION":"UN","MASTER_ID":35635,"ec":"2.4.1.296","compounds":"an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + UDP-alpha-D-glucose = an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] 5-O-beta-D-glucoside + H(+) + UDP"}
{"X":27763,"RHEA_ID":35636,"DIRECTION":"LR","MASTER_ID":35635,"metacyc":"RXN-13964","compounds":"an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + UDP-alpha-D-glucose => an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] 5-O-beta-D-glucoside + H(+) + UDP"}
{"X":27764,"RHEA_ID":25041,"DIRECTION":"UN","MASTER_ID":25041,"ec":"2.9.1.2","compounds":"H2O + O-phospho-L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + 2 phosphate"}
{"X":27765,"RHEA_ID":25042,"DIRECTION":"LR","MASTER_ID":25041,"metacyc":"RXN-10039","compounds":"H2O + O-phospho-L-seryl-tRNA(Sec) + selenophosphate => L-selenocysteinyl-tRNA(Sec) + 2 phosphate"}
{"X":27766,"RHEA_ID":25043,"compounds":"L-selenocysteinyl-tRNA(Sec) + 2 phosphate => H2O + O-phospho-L-seryl-tRNA(Sec) + selenophosphate"}
{"X":27767,"RHEA_ID":25046,"compounds":"(2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)"}
{"X":27768,"RHEA_ID":25047,"DIRECTION":"LR","MASTER_ID":25046,"ecocyc":"RXN-12070","metacyc":"RXN-12070","compounds":"(2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O => (2E)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)"}
{"X":27769,"RHEA_ID":25048,"compounds":"(2E)-2-hydroxypenta-2,4-dienoate + fumarate + H(+) => (2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O"}
{"X":27770,"RHEA_ID":35644,"compounds":"a (2R)-2-hydroxycarboxylate + NAD(+) => a 2-oxocarboxylate + H(+) + NADH"}
{"X":27771,"RHEA_ID":25054,"DIRECTION":"UN","MASTER_ID":25054,"ec":"1.13.11.16","compounds":"(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O2 = (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H(+)"}
{"X":27772,"RHEA_ID":25055,"DIRECTION":"LR","MASTER_ID":25054,"ecocyc":"RXN-12073","metacyc":"RXN-12073","compounds":"(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O2 => (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H(+)"}
{"X":27773,"RHEA_ID":35647,"compounds":"ATP + GTP = 3',3'-cGAMP + 2 diphosphate"}
{"X":27774,"RHEA_ID":35648,"DIRECTION":"LR","MASTER_ID":35647,"reactome":"R-HSA-3244614.3","compounds":"ATP + GTP => 3',3'-cGAMP + 2 diphosphate"}
{"X":27775,"RHEA_ID":25058,"DIRECTION":"UN","MASTER_ID":25058,"ec":"1.14.12.19","compounds":"H(+) + NADH + O2 + trans-cinnamate = (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+)"}
{"X":27776,"RHEA_ID":25059,"DIRECTION":"LR","MASTER_ID":25058,"ecocyc":"RXN-12072","metacyc":"RXN-12072","compounds":"H(+) + NADH + O2 + trans-cinnamate => (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+)"}
{"X":27777,"RHEA_ID":35651,"compounds":"4-hydroxysphinganine + an acyl-CoA = an N-acyl-(4R)-4-hydroxysphinganine + CoA + H(+)"}
{"X":27778,"RHEA_ID":35652,"compounds":"4-hydroxysphinganine + an acyl-CoA => an N-acyl-(4R)-4-hydroxysphinganine + CoA + H(+)"}
{"X":27779,"RHEA_ID":25062,"DIRECTION":"UN","MASTER_ID":25062,"ec":"1.3.1.87","compounds":"3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+) = 3-(2,3-dihydroxyphenyl)propanoate + H(+) + NADH"}
{"X":27780,"RHEA_ID":25063,"DIRECTION":"LR","MASTER_ID":25062,"ecocyc":"PHENPRODIOLDEHYDROG-RXN","metacyc":"PHENPRODIOLDEHYDROG-RXN","compounds":"3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+) => 3-(2,3-dihydroxyphenyl)propanoate + H(+) + NADH"}
{"X":27781,"RHEA_ID":25064,"compounds":"3-(2,3-dihydroxyphenyl)propanoate + H(+) + NADH => 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+)"}
{"X":27782,"RHEA_ID":35656,"compounds":"2 ATP => 3',3'-c-di-AMP + 2 diphosphate"}
{"X":27783,"RHEA_ID":25066,"DIRECTION":"UN","MASTER_ID":25066,"ec":"1.3.1.87","compounds":"(2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+) = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H(+) + NADH"}
{"X":27784,"RHEA_ID":25067,"DIRECTION":"LR","MASTER_ID":25066,"ecocyc":"RXN-12071","metacyc":"RXN-12071","compounds":"(2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+) => (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H(+) + NADH"}
{"X":27785,"RHEA_ID":35659,"compounds":"an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + GDP-alpha-D-mannose = GDP + H(+) + mannosylinositol phosphorylphytoceramide"}
{"X":27786,"RHEA_ID":35660,"compounds":"an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + GDP-alpha-D-mannose => GDP + H(+) + mannosylinositol phosphorylphytoceramide"}
{"X":27787,"RHEA_ID":25070,"DIRECTION":"UN","MASTER_ID":25070,"ec":"6.2.1.37","compounds":"3-hydroxybenzoate + ATP + CoA = 3-hydroxybenzoyl-CoA + AMP + diphosphate"}
{"X":27788,"RHEA_ID":25071,"DIRECTION":"LR","MASTER_ID":25070,"metacyc":"RXN-7488","compounds":"3-hydroxybenzoate + ATP + CoA => 3-hydroxybenzoyl-CoA + AMP + diphosphate"}
{"X":27789,"RHEA_ID":35663,"compounds":"a 1,2-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)"}
{"X":27790,"RHEA_ID":25073,"compounds":"3-hydroxybenzoate + ATP + CoA <=> 3-hydroxybenzoyl-CoA + AMP + diphosphate"}
{"X":27791,"RHEA_ID":25074,"DIRECTION":"UN","MASTER_ID":25074,"ec":"4.2.1.92","compounds":"(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate = (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate + H2O"}
{"X":27792,"RHEA_ID":25075,"DIRECTION":"LR","MASTER_ID":25074,"metacyc":"RXN1F-19","compounds":"(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate + H2O"}
{"X":27793,"RHEA_ID":35667,"compounds":"a triacylglycerol + H2O = a 1,2-diacylglycerol + a fatty acid + H(+)"}
{"X":27794,"RHEA_ID":35668,"compounds":"a triacylglycerol + H2O => a 1,2-diacylglycerol + a fatty acid + H(+)"}
{"X":27795,"RHEA_ID":25078,"compounds":"(2S)-2-isopropyl-3-oxosuccinate + H(+) = 4-methyl-2-oxopentanoate + CO2"}
{"X":27796,"RHEA_ID":25079,"DIRECTION":"LR","MASTER_ID":25078,"ecocyc":"RXN-7800","metacyc":"RXN-7800","compounds":"(2S)-2-isopropyl-3-oxosuccinate + H(+) => 4-methyl-2-oxopentanoate + CO2"}
{"X":27797,"RHEA_ID":25080,"compounds":"4-methyl-2-oxopentanoate + CO2 => (2S)-2-isopropyl-3-oxosuccinate + H(+)"}
{"X":27798,"RHEA_ID":35672,"DIRECTION":"LR","MASTER_ID":35671,"metacyc":"RXN-9485","compounds":"(S)-5'-oxoaverantin + H(+) => (1'S,5'S)-averufin + H2O"}
{"X":27799,"RHEA_ID":25094,"DIRECTION":"UN","MASTER_ID":25094,"ec":"2.7.4.25","compounds":"ATP + dCMP = ADP + dCDP"}
{"X":27800,"RHEA_ID":25094,"DIRECTION":"UN","MASTER_ID":25094,"ec":"2.7.4.14","compounds":"ATP + dCMP = ADP + dCDP"}
{"X":27801,"RHEA_ID":35675,"compounds":"H(+) + L-serine + tetradecanoyl-CoA = 3-oxohexadecasphinganine + CO2 + CoA"}
{"X":27802,"RHEA_ID":25095,"DIRECTION":"LR","MASTER_ID":25094,"ecocyc":"RXN-7913","metacyc":"RXN-7913","compounds":"ATP + dCMP => ADP + dCDP"}
{"X":27803,"RHEA_ID":25095,"DIRECTION":"LR","MASTER_ID":25094,"ecocyc":"RXN-11831","metacyc":"RXN-11831","compounds":"ATP + dCMP => ADP + dCDP"}
{"X":27804,"RHEA_ID":25095,"DIRECTION":"LR","MASTER_ID":25094,"ecocyc":"RXN-11831","metacyc":"RXN-7913","compounds":"ATP + dCMP => ADP + dCDP"}
{"X":27805,"RHEA_ID":35679,"compounds":"dodecanoyl-CoA + H(+) + L-serine = 3-oxotetradecasphinganine + CO2 + CoA"}
{"X":27806,"RHEA_ID":35680,"compounds":"dodecanoyl-CoA + H(+) + L-serine => 3-oxotetradecasphinganine + CO2 + CoA"}
{"X":27807,"RHEA_ID":25098,"DIRECTION":"UN","MASTER_ID":25098,"ec":"2.7.4.6","compounds":"ATP + UDP = ADP + UTP"}
{"X":27808,"RHEA_ID":25099,"DIRECTION":"LR","MASTER_ID":25098,"ecocyc":"UDPKIN-RXN","metacyc":"UDPKIN-RXN","compounds":"ATP + UDP => ADP + UTP"}
{"X":27809,"RHEA_ID":35683,"compounds":"hexadecasphinganine + NADP(+) = 3-oxohexadecasphinganine + H(+) + NADPH"}
{"X":27810,"RHEA_ID":35684,"compounds":"hexadecasphinganine + NADP(+) => 3-oxohexadecasphinganine + H(+) + NADPH"}
{"X":27811,"RHEA_ID":25104,"DIRECTION":"UN","MASTER_ID":25104,"ec":"2.7.1.35","compounds":"ATP + pyridoxamine = ADP + H(+) + pyridoxamine 5'-phosphate"}
{"X":27812,"RHEA_ID":25105,"DIRECTION":"LR","MASTER_ID":25104,"ecocyc":"PYRAMKIN-RXN","metacyc":"PYRAMKIN-RXN","reactome":"R-HSA-964958.1","compounds":"ATP + pyridoxamine => ADP + H(+) + pyridoxamine 5'-phosphate"}
{"X":27813,"RHEA_ID":25106,"compounds":"ADP + H(+) + pyridoxamine 5'-phosphate => ATP + pyridoxamine"}
{"X":27814,"RHEA_ID":35688,"compounds":"NADP(+) + tetradecasphinganine => 3-oxotetradecasphinganine + H(+) + NADPH"}
{"X":27815,"RHEA_ID":25108,"DIRECTION":"UN","MASTER_ID":25108,"ec":"2.7.1.35","compounds":"ATP + pyridoxine = ADP + H(+) + pyridoxine 5'-phosphate"}
{"X":27816,"RHEA_ID":25109,"DIRECTION":"LR","MASTER_ID":25108,"ecocyc":"PNKIN-RXN","metacyc":"PNKIN-RXN","reactome":"R-HSA-964962.1","compounds":"ATP + pyridoxine => ADP + H(+) + pyridoxine 5'-phosphate"}
{"X":27817,"RHEA_ID":35691,"DIRECTION":"UN","MASTER_ID":35691,"ec":"1.1.1.353","compounds":"(2S)-versicolorone + NADP(+) = 1'-hydroxyversicolorone + H(+) + NADPH"}
{"X":27818,"RHEA_ID":35692,"compounds":"(2S)-versicolorone + NADP(+) => 1'-hydroxyversicolorone + H(+) + NADPH"}
{"X":27819,"RHEA_ID":25112,"DIRECTION":"UN","MASTER_ID":25112,"ec":"3.1.3.74","compounds":"H2O + pyridoxine 5'-phosphate = phosphate + pyridoxine"}
{"X":27820,"RHEA_ID":25113,"compounds":"H2O + pyridoxine 5'-phosphate => phosphate + pyridoxine"}
{"X":27821,"RHEA_ID":35695,"DIRECTION":"UN","MASTER_ID":35695,"ec":"1.1.1.353","compounds":"(3S)-versiconol acetate + NADP(+) = (2S,3S)-versiconal hemiacetal acetate + H(+) + NADPH"}
{"X":27822,"RHEA_ID":35696,"compounds":"(3S)-versiconol acetate + NADP(+) => (2S,3S)-versiconal hemiacetal acetate + H(+) + NADPH"}
{"X":27823,"RHEA_ID":25117,"compounds":"H2O + L-lysine + NAD(+) = (S)-2-amino-6-oxohexanoate + H(+) + NADH + NH4(+)"}
{"X":27824,"RHEA_ID":25118,"DIRECTION":"LR","MASTER_ID":25117,"metacyc":"RXN-8808","compounds":"H2O + L-lysine + NAD(+) => (S)-2-amino-6-oxohexanoate + H(+) + NADH + NH4(+)"}
{"X":27825,"RHEA_ID":25119,"compounds":"(S)-2-amino-6-oxohexanoate + H(+) + NADH + NH4(+) => H2O + L-lysine + NAD(+)"}
{"X":27826,"RHEA_ID":35700,"compounds":"(S)-versiconol + NADP(+) => (2S-3S)-versiconal hemiacetal + H(+) + NADPH"}
{"X":27827,"RHEA_ID":25121,"compounds":"(S)-2-amino-6-oxohexanoate = H(+) + H2O + L-1-piperideine-6-carboxylate"}
{"X":27828,"RHEA_ID":25122,"compounds":"(S)-2-amino-6-oxohexanoate => H(+) + H2O + L-1-piperideine-6-carboxylate"}
{"X":27829,"RHEA_ID":25123,"compounds":"H(+) + H2O + L-1-piperideine-6-carboxylate => (S)-2-amino-6-oxohexanoate"}
{"X":27830,"RHEA_ID":35704,"DIRECTION":"LR","MASTER_ID":35703,"metacyc":"RXN-9487","compounds":"1'-hydroxyversicolorone + H(+) + NADPH + O2 => (2S,3S)-versiconal hemiacetal acetate + H2O + NADP(+)"}
{"X":27831,"RHEA_ID":25135,"DIRECTION":"UN","MASTER_ID":25135,"ec":"3.1.3.74","compounds":"phosphate + pyridoxamine = H2O + pyridoxamine 5'-phosphate"}
{"X":27832,"RHEA_ID":25136,"compounds":"phosphate + pyridoxamine => H2O + pyridoxamine 5'-phosphate"}
{"X":27833,"RHEA_ID":35707,"compounds":"(2S)-versicolorone + H(+) + NADPH + O2 = (3S)-versiconol acetate + H2O + NADP(+)"}
{"X":27834,"RHEA_ID":35708,"DIRECTION":"LR","MASTER_ID":35707,"metacyc":"RXN-9492","compounds":"(2S)-versicolorone + H(+) + NADPH + O2 => (3S)-versiconol acetate + H2O + NADP(+)"}
{"X":27835,"RHEA_ID":25139,"compounds":"(2S)-2-amino-3-oxo-4-(phosphooxy)butanoate + H(+) = 3-amino-2-oxopropyl phosphate + CO2"}
{"X":27836,"RHEA_ID":25140,"DIRECTION":"LR","MASTER_ID":25139,"ecocyc":"RXN-8447","metacyc":"RXN-8447","compounds":"(2S)-2-amino-3-oxo-4-(phosphooxy)butanoate + H(+) => 3-amino-2-oxopropyl phosphate + CO2"}
{"X":27837,"RHEA_ID":25141,"compounds":"3-amino-2-oxopropyl phosphate + CO2 => (2S)-2-amino-3-oxo-4-(phosphooxy)butanoate + H(+)"}
{"X":27838,"RHEA_ID":35712,"compounds":"acetate + succinyl-CoA => acetyl-CoA + succinate"}
{"X":27839,"RHEA_ID":25143,"DIRECTION":"UN","MASTER_ID":25143,"ec":"3.7.1.3","compounds":"3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + H(+) + L-alanine"}
{"X":27840,"RHEA_ID":25144,"DIRECTION":"LR","MASTER_ID":25143,"metacyc":"3-HYDROXY-KYNURENINASE-RXN","reactome":"R-HSA-71217.2","compounds":"3-hydroxy-L-kynurenine + H2O => 3-hydroxyanthranilate + H(+) + L-alanine"}
{"X":27841,"RHEA_ID":35715,"DIRECTION":"UN","MASTER_ID":35715,"ec":"3.1.1.94","compounds":"(2S,3S)-versiconal hemiacetal acetate + H2O = (2S-3S)-versiconal hemiacetal + acetate + H(+)"}
{"X":27842,"RHEA_ID":35716,"DIRECTION":"LR","MASTER_ID":35715,"metacyc":"RXN-9488","compounds":"(2S,3S)-versiconal hemiacetal acetate + H2O => (2S-3S)-versiconal hemiacetal + acetate + H(+)"}
{"X":27843,"RHEA_ID":25147,"compounds":"(2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde = H(+) + H2O + quinolinate"}
{"X":27844,"RHEA_ID":25148,"DIRECTION":"LR","MASTER_ID":25147,"metacyc":"RXN-5721","compounds":"(2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde => H(+) + H2O + quinolinate"}
{"X":27845,"RHEA_ID":35719,"DIRECTION":"UN","MASTER_ID":35719,"ec":"3.1.1.94","compounds":"(3S)-versiconol acetate + H2O = (S)-versiconol + acetate + H(+)"}
{"X":27846,"RHEA_ID":35720,"DIRECTION":"LR","MASTER_ID":35719,"metacyc":"RXN-9492","compounds":"(3S)-versiconol acetate + H2O => (S)-versiconol + acetate + H(+)"}
{"X":27847,"RHEA_ID":25152,"DIRECTION":"UN","MASTER_ID":25152,"ec":"2.6.1.5","compounds":"2-oxoglutarate + L-phenylalanine = 3-phenylpyruvate + L-glutamate"}
{"X":27848,"RHEA_ID":25152,"DIRECTION":"UN","MASTER_ID":25152,"ec":"2.6.1.57","compounds":"2-oxoglutarate + L-phenylalanine = 3-phenylpyruvate + L-glutamate"}
{"X":27849,"RHEA_ID":25153,"compounds":"2-oxoglutarate + L-phenylalanine => 3-phenylpyruvate + L-glutamate"}
{"X":27850,"RHEA_ID":25154,"compounds":"3-phenylpyruvate + L-glutamate => 2-oxoglutarate + L-phenylalanine"}
{"X":27851,"RHEA_ID":35725,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphate + CoA => hexadecanoyl-CoA + sn-glycerol 3-phosphate"}
{"X":27852,"RHEA_ID":25156,"DIRECTION":"UN","MASTER_ID":25156,"ec":"6.3.2.51","compounds":"(R)-4'-phosphopantothenate + ATP + L-cysteine = AMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine"}
{"X":27853,"RHEA_ID":35727,"compounds":"dodecanoyl-CoA + sn-glycerol 3-phosphate = 1-dodecanoyl-sn-glycerol 3-phosphate + CoA"}
{"X":27854,"RHEA_ID":25158,"compounds":"AMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine => (R)-4'-phosphopantothenate + ATP + L-cysteine"}
{"X":27855,"RHEA_ID":35729,"compounds":"1-dodecanoyl-sn-glycerol 3-phosphate + CoA => dodecanoyl-CoA + sn-glycerol 3-phosphate"}
{"X":27856,"RHEA_ID":25160,"DIRECTION":"UN","MASTER_ID":25160,"ec":"2.6.1.13","compounds":"2-oxoglutarate + L-ornithine = L-glutamate + L-glutamate 5-semialdehyde"}
{"X":27857,"RHEA_ID":35731,"compounds":"sn-glycerol 3-phosphate + tetradecanoyl-CoA = 1-tetradecanoyl-sn-glycerol 3-phosphate + CoA"}
{"X":27858,"RHEA_ID":25162,"DIRECTION":"RL","MASTER_ID":25160,"reactome":"R-HSA-70666.3","compounds":"L-glutamate + L-glutamate 5-semialdehyde => 2-oxoglutarate + L-ornithine"}
{"X":27859,"RHEA_ID":35733,"compounds":"1-tetradecanoyl-sn-glycerol 3-phosphate + CoA => sn-glycerol 3-phosphate + tetradecanoyl-CoA"}
{"X":27860,"RHEA_ID":25164,"compounds":"A + butanoyl-CoA = (2E)-butenoyl-CoA + AH2"}
{"X":27861,"RHEA_ID":35735,"DIRECTION":"UN","MASTER_ID":35735,"ec":"1.1.1.272","compounds":"a (2R)-2-hydroxycarboxylate + NADP(+) = a 2-oxocarboxylate + H(+) + NADPH"}
{"X":27862,"RHEA_ID":25166,"compounds":"(2E)-butenoyl-CoA + AH2 => A + butanoyl-CoA"}
{"X":27863,"RHEA_ID":25168,"compounds":"6-hydroxyhexan-6-olide = 6-oxohexanoate + H(+)"}
{"X":27864,"RHEA_ID":35739,"DIRECTION":"UN","MASTER_ID":35739,"ec":"1.14.15.6","compounds":"cholesterol + 6 H(+) + 3 O2 + 6 reduced [adrenodoxin] = 4-methylpentanal + 4 H2O + 6 oxidized [adrenodoxin] + pregnenolone"}
{"X":27865,"RHEA_ID":25170,"compounds":"6-oxohexanoate + H(+) => 6-hydroxyhexan-6-olide"}
{"X":27866,"RHEA_ID":25171,"DIRECTION":"BI","MASTER_ID":25168,"metacyc":"RXN-14101","compounds":"6-hydroxyhexan-6-olide <=> 6-oxohexanoate + H(+)"}
{"X":27867,"RHEA_ID":25173,"DIRECTION":"UN","MASTER_ID":25173,"ec":"3.5.3.18","compounds":"H2O + N(omega)-methyl-L-arginine = L-citrulline + methylamine"}
{"X":27868,"RHEA_ID":35743,"DIRECTION":"UN","MASTER_ID":35743,"ec":"1.14.19.n5","compounds":"H(+) + NADPH + O2 + versicolorin B = 2 H2O + NADP(+) + versicolorin A"}
{"X":27869,"RHEA_ID":25175,"compounds":"L-citrulline + methylamine => H2O + N(omega)-methyl-L-arginine"}
{"X":27870,"RHEA_ID":25176,"compounds":"H2O + N(omega)-methyl-L-arginine <=> L-citrulline + methylamine"}
{"X":27871,"RHEA_ID":25177,"DIRECTION":"UN","MASTER_ID":25177,"ec":"1.2.1.25","compounds":"4-methyl-2-oxopentanoate + CoA + NAD(+) = 3-methylbutanoyl-CoA + CO2 + NADH"}
{"X":27872,"RHEA_ID":35747,"DIRECTION":"UN","MASTER_ID":35747,"ec":"4.2.3.142","compounds":"(2E,6E)-farnesyl diphosphate = 7-epizingiberene + diphosphate"}
{"X":27873,"RHEA_ID":25179,"compounds":"3-methylbutanoyl-CoA + CO2 + NADH => 4-methyl-2-oxopentanoate + CoA + NAD(+)"}
{"X":27874,"RHEA_ID":35749,"compounds":"7-epizingiberene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":27875,"RHEA_ID":25181,"DIRECTION":"UN","MASTER_ID":25181,"ec":"2.3.1.57","compounds":"acetyl-CoA + putrescine = CoA + H(+) + N-acetylputrescine"}
{"X":27876,"RHEA_ID":35751,"DIRECTION":"UN","MASTER_ID":35751,"ec":"2.7.1.179","compounds":"ATP + kanosamine = ADP + D-kanosamine 6-phosphate + H(+)"}
{"X":27877,"RHEA_ID":25183,"compounds":"CoA + H(+) + N-acetylputrescine => acetyl-CoA + putrescine"}
{"X":27878,"RHEA_ID":35753,"compounds":"ADP + D-kanosamine 6-phosphate + H(+) => ATP + kanosamine"}
{"X":27879,"RHEA_ID":25185,"DIRECTION":"UN","MASTER_ID":25185,"ec":"3.8.1.5","compounds":"1,2-dichloroethane + H2O = 2-chloroethanol + chloride + H(+)"}
{"X":27880,"RHEA_ID":35755,"compounds":"NAD(+) + UDP-alpha-D-glucose = H(+) + NADH + UDP-3-oxo-alpha-D-glucose"}
{"X":27881,"RHEA_ID":25187,"compounds":"2-chloroethanol + chloride + H(+) => 1,2-dichloroethane + H2O"}
{"X":27882,"RHEA_ID":25189,"DIRECTION":"UN","MASTER_ID":25189,"ec":"3.8.1.3","compounds":"chloroacetate + H2O = chloride + glycolate + H(+)"}
{"X":27883,"RHEA_ID":35759,"DIRECTION":"UN","MASTER_ID":35759,"ec":"1.14.14.117","compounds":"8-O-methylsterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = aflatoxin B1 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":27884,"RHEA_ID":25191,"compounds":"chloride + glycolate + H(+) => chloroacetate + H2O"}
{"X":27885,"RHEA_ID":25193,"DIRECTION":"UN","MASTER_ID":25193,"ec":"1.3.1.19","compounds":"(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+) = 3-methylcatechol + H(+) + NADH"}
{"X":27886,"RHEA_ID":25194,"DIRECTION":"LR","MASTER_ID":25193,"metacyc":"TOLUENE-DIOL-DEHYDROGENASE-RXN","compounds":"(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+) => 3-methylcatechol + H(+) + NADH"}
{"X":27887,"RHEA_ID":25195,"compounds":"3-methylcatechol + H(+) + NADH => (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+)"}
{"X":27888,"RHEA_ID":35765,"compounds":"aflatoxin B2 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase] => 8-O-methyldihydrosterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}
{"X":27889,"RHEA_ID":25197,"DIRECTION":"UN","MASTER_ID":25197,"ec":"3.1.3.104","compounds":"5-amino-6-(5-phospho-D-ribitylamino)uracil + H2O = 5-amino-6-(D-ribitylamino)uracil + phosphate"}
{"X":27890,"RHEA_ID":35767,"DIRECTION":"UN","MASTER_ID":35767,"ec":"2.1.1.110","compounds":"dihydrosterigmatocystin + S-adenosyl-L-methionine = 8-O-methyldihydrosterigmatocystin + H(+) + S-adenosyl-L-homocysteine"}
{"X":27891,"RHEA_ID":25199,"compounds":"5-amino-6-(D-ribitylamino)uracil + phosphate => 5-amino-6-(5-phospho-D-ribitylamino)uracil + H2O"}
{"X":27892,"RHEA_ID":35769,"compounds":"8-O-methyldihydrosterigmatocystin + H(+) + S-adenosyl-L-homocysteine => dihydrosterigmatocystin + S-adenosyl-L-methionine"}
{"X":27893,"RHEA_ID":25201,"DIRECTION":"UN","MASTER_ID":25201,"ec":"4.1.2.43","compounds":"D-ribulose 5-phosphate + formaldehyde = D-arabino-hex-3-ulose 6-phosphate"}
{"X":27894,"RHEA_ID":35771,"DIRECTION":"UN","MASTER_ID":35771,"ec":"4.2.1.144","compounds":"5-deoxy-5-amino-3-dehydroshikimate = 3-amino-5-hydroxybenzoate + H(+) + H2O"}
{"X":27895,"RHEA_ID":25203,"compounds":"D-arabino-hex-3-ulose 6-phosphate => D-ribulose 5-phosphate + formaldehyde"}
{"X":27896,"RHEA_ID":35773,"compounds":"3-amino-5-hydroxybenzoate + H(+) + H2O => 5-deoxy-5-amino-3-dehydroshikimate"}
{"X":27897,"RHEA_ID":25209,"DIRECTION":"UN","MASTER_ID":25209,"ec":"3.5.1.108","compounds":"H2O + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine = acetate + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine"}
{"X":27898,"RHEA_ID":35775,"compounds":"L-glutamine + UDP-3-oxo-alpha-D-glucose = 2-oxoglutaramate + UDP-alpha-D-kanosamine"}
{"X":27899,"RHEA_ID":25211,"compounds":"acetate + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine => H2O + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine"}
{"X":27900,"RHEA_ID":35777,"compounds":"2-oxoglutaramate + UDP-alpha-D-kanosamine => L-glutamine + UDP-3-oxo-alpha-D-glucose"}
{"X":27901,"RHEA_ID":25213,"DIRECTION":"UN","MASTER_ID":25213,"ec":"3.6.1.54","compounds":"H2O + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine = 2-N,3-O-bis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP"}
{"X":27902,"RHEA_ID":25214,"DIRECTION":"LR","MASTER_ID":25213,"ecocyc":"LIPIDXSYNTHESIS-RXN","metacyc":"LIPIDXSYNTHESIS-RXN","compounds":"H2O + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine => 2-N,3-O-bis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP"}
{"X":27903,"RHEA_ID":25215,"compounds":"2-N,3-O-bis(3-hydroxytetradecanoyl)-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP => H2O + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine"}
{"X":27904,"RHEA_ID":25217,"DIRECTION":"UN","MASTER_ID":25217,"ec":"2.3.1.87","compounds":"acetyl-CoA + serotonin = CoA + H(+) + N-acetylserotonin"}
{"X":27905,"RHEA_ID":25218,"DIRECTION":"LR","MASTER_ID":25217,"macie":"M0022","metacyc":"RXN3DJ-35528","reactome":"R-HSA-209792.1","compounds":"acetyl-CoA + serotonin => CoA + H(+) + N-acetylserotonin"}
{"X":27906,"RHEA_ID":25219,"compounds":"CoA + H(+) + N-acetylserotonin => acetyl-CoA + serotonin"}
{"X":27907,"RHEA_ID":35785,"compounds":"H(+) + kanamycin B + UDP => neamine + UDP-alpha-D-kanosamine"}
{"X":27908,"RHEA_ID":25221,"DIRECTION":"UN","MASTER_ID":25221,"ec":"4.1.1.29","compounds":"H(+) + L-cysteate = CO2 + taurine"}
{"X":27909,"RHEA_ID":35787,"DIRECTION":"UN","MASTER_ID":35787,"ec":"2.4.1.301","compounds":"paromamine + UDP-alpha-D-kanosamine = H(+) + kanamycin C + UDP"}
{"X":27910,"RHEA_ID":25223,"compounds":"CO2 + taurine => H(+) + L-cysteate"}
{"X":27911,"RHEA_ID":35789,"compounds":"H(+) + kanamycin C + UDP => paromamine + UDP-alpha-D-kanosamine"}
{"X":27912,"RHEA_ID":25225,"DIRECTION":"UN","MASTER_ID":25225,"ec":"1.1.1.21","compounds":"L-arabinitol + NAD(+) = H(+) + L-arabinose + NADH"}
{"X":27913,"RHEA_ID":35791,"DIRECTION":"UN","MASTER_ID":35791,"ec":"2.4.1.301","compounds":"2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-kanosamine = H(+) + kanamycin X + UDP"}
{"X":27914,"RHEA_ID":25227,"compounds":"H(+) + L-arabinose + NADH => L-arabinitol + NAD(+)"}
{"X":27915,"RHEA_ID":35793,"compounds":"H(+) + kanamycin X + UDP => 2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-kanosamine"}
{"X":27916,"RHEA_ID":45719,"compounds":"H2O + N,N,N-trimethylglycyl-CoA <=> betaine + CoA + H(+)"}
{"X":27917,"RHEA_ID":25229,"DIRECTION":"UN","MASTER_ID":25229,"ec":"1.1.1.21","compounds":"L-arabinitol + NADP(+) = H(+) + L-arabinose + NADPH"}
{"X":27918,"RHEA_ID":25230,"compounds":"L-arabinitol + NADP(+) => H(+) + L-arabinose + NADPH"}
{"X":27919,"RHEA_ID":25231,"compounds":"H(+) + L-arabinose + NADPH => L-arabinitol + NADP(+)"}
{"X":27920,"RHEA_ID":45723,"compounds":"N-hexadecanoylsphing-4-enine(in) <=> N-hexadecanoylsphing-4-enine(out)"}
{"X":27921,"RHEA_ID":35799,"DIRECTION":"UN","MASTER_ID":35799,"ec":"3.1.4.56","compounds":"7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O = 7,8-dihydroneopterin 3'-phosphate + H(+)"}
{"X":27922,"RHEA_ID":25234,"compounds":"N-acetyl-alpha-neuraminate => N-acetyl-beta-neuraminate"}
{"X":27923,"RHEA_ID":25235,"compounds":"N-acetyl-beta-neuraminate => N-acetyl-alpha-neuraminate"}
{"X":27924,"RHEA_ID":25236,"compounds":"N-acetyl-alpha-neuraminate <=> N-acetyl-beta-neuraminate"}
{"X":27925,"RHEA_ID":35803,"DIRECTION":"UN","MASTER_ID":35803,"ec":"3.1.4.56","compounds":"7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O = 7,8-dihydroneopterin 2'-phosphate + H(+)"}
{"X":27926,"RHEA_ID":25238,"DIRECTION":"LR","MASTER_ID":25237,"ecocyc":"CDPKIN-RXN","metacyc":"CDPKIN-RXN","compounds":"ATP + CDP => ADP + CTP"}
{"X":27927,"RHEA_ID":25239,"compounds":"ADP + CTP => ATP + CDP"}
{"X":27928,"RHEA_ID":55744,"DIRECTION":"UN","MASTER_ID":55744,"ec":"1.8.98.4","compounds":"coenzyme B + coenzyme M + 4 H(+) + 2 oxidized coenzyme F420-(gamma-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin] = coenzyme M-coenzyme B heterodisulfide + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 reduced coenzyme F420-(gamma-Glu)(n)"}
{"X":27929,"RHEA_ID":35807,"DIRECTION":"UN","MASTER_ID":35807,"ec":"4.2.1.141","compounds":"2-dehydro-3-deoxy-D-arabinonate = 2,5-dioxopentanoate + H2O"}
{"X":27930,"RHEA_ID":25242,"DIRECTION":"LR","MASTER_ID":25241,"ecocyc":"URUR-RXN","metacyc":"URUR-RXN","compounds":"(S)-2-ureidoglycine + H2O => (S)-ureidoglycolate + NH4(+)"}
{"X":27931,"RHEA_ID":25243,"compounds":"(S)-ureidoglycolate + NH4(+) => (S)-2-ureidoglycine + H2O"}
{"X":27932,"RHEA_ID":45735,"compounds":"D-ribulose 5-phosphate + L-tyrosine <=> (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate"}
{"X":27933,"RHEA_ID":35811,"DIRECTION":"UN","MASTER_ID":35811,"ec":"4.2.1.139","compounds":"(3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol = (-)-medicarpin + H2O"}
{"X":27934,"RHEA_ID":25246,"DIRECTION":"LR","MASTER_ID":25245,"macie":"M0157","metacyc":"GLYOXII-RXN","compounds":"(R)-S-lactoylglutathione + H2O => (R)-lactate + glutathione + H(+)"}
{"X":27935,"RHEA_ID":25247,"compounds":"(R)-lactate + glutathione + H(+) => (R)-S-lactoylglutathione + H2O"}
{"X":27936,"RHEA_ID":45739,"compounds":"(3E)-hexenoyl-CoA <=> (2E)-hexenoyl-CoA"}
{"X":27937,"RHEA_ID":35815,"compounds":"4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) = 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate"}
{"X":27938,"RHEA_ID":25250,"DIRECTION":"LR","MASTER_ID":25249,"ecocyc":"ACETOLACTSYN-RXN","metacyc":"ACETOLACTSYN-RXN","compounds":"H(+) + 2 pyruvate => (2S)-2-acetolactate + CO2"}
{"X":27939,"RHEA_ID":25251,"DIRECTION":"RL","MASTER_ID":25249,"macie":"M0289","compounds":"(2S)-2-acetolactate + CO2 => H(+) + 2 pyruvate"}
{"X":27940,"RHEA_ID":35819,"DIRECTION":"UN","MASTER_ID":35819,"ec":"1.5.1.47","compounds":"5,6,7,8-tetrahydromethanopterin + NADP(+) = 7,8-dihydromethanopterin + H(+) + NADPH"}
{"X":27941,"RHEA_ID":25254,"DIRECTION":"LR","MASTER_ID":25253,"ecocyc":"NANK-RXN","metacyc":"NANK-RXN","reactome":"R-HSA-4085028.1","compounds":"ATP + N-acetyl-D-mannosamine => ADP + H(+) + N-acetyl-D-mannosamine 6-phosphate"}
{"X":27942,"RHEA_ID":25255,"compounds":"ADP + H(+) + N-acetyl-D-mannosamine 6-phosphate => ATP + N-acetyl-D-mannosamine"}
{"X":27943,"RHEA_ID":45747,"compounds":"(6S)-5,6,7,8-tetrahydropteroate + NAD(+) <=> 7,8-dihydropteroate + H(+) + NADH"}
{"X":27944,"RHEA_ID":35823,"DIRECTION":"UN","MASTER_ID":35823,"ec":"1.5.1.47","compounds":"5,6,7,8-tetrahydromethanopterin + NAD(+) = 7,8-dihydromethanopterin + H(+) + NADH"}
{"X":27945,"RHEA_ID":25258,"compounds":"N-acetyl-D-glucosamine 6-phosphate => N-acetyl-D-mannosamine 6-phosphate"}
{"X":27946,"RHEA_ID":25259,"DIRECTION":"RL","MASTER_ID":25257,"metacyc":"NANE-RXN","compounds":"N-acetyl-D-mannosamine 6-phosphate => N-acetyl-D-glucosamine 6-phosphate"}
{"X":27947,"RHEA_ID":45751,"compounds":"(3Z)-hexenoyl-CoA <=> (2E)-hexenoyl-CoA"}
{"X":27948,"RHEA_ID":35827,"DIRECTION":"UN","MASTER_ID":35827,"ec":"3.5.3.24","compounds":"H2O + N(1)-aminopropylagmatine = spermidine + urea"}
{"X":27949,"RHEA_ID":25262,"compounds":"2-hydroxyglutarate + FAD + H(+) => 2-oxoglutarate + FADH2"}
{"X":27950,"RHEA_ID":25263,"compounds":"2-oxoglutarate + FADH2 => 2-hydroxyglutarate + FAD + H(+)"}
{"X":27951,"RHEA_ID":45755,"DIRECTION":"BI","MASTER_ID":45752,"metacyc":"RXN-14804","compounds":"(3E)-decenoyl-CoA <=> (2E)-decenoyl-CoA"}
{"X":27952,"RHEA_ID":35831,"DIRECTION":"UN","MASTER_ID":35831,"ec":"1.14.11.37","compounds":"2-oxoglutarate + kanamycin B + O2 = 2'-dehydrokanamycin A + CO2 + NH4(+) + succinate"}
{"X":27953,"RHEA_ID":25266,"DIRECTION":"LR","MASTER_ID":25265,"ecocyc":"AMINEPHEN-RXN","metacyc":"RXN-10817","reactome":"R-HSA-141200.1","compounds":"2-phenylethylamine + H2O + O2 => 2-phenylacetaldehyde + H2O2 + NH4(+)"}
{"X":27954,"RHEA_ID":25266,"DIRECTION":"LR","MASTER_ID":25265,"ecocyc":"AMINEPHEN-RXN","metacyc":"AMINEPHEN-RXN","reactome":"R-HSA-141200.1","compounds":"2-phenylethylamine + H2O + O2 => 2-phenylacetaldehyde + H2O2 + NH4(+)"}
{"X":27955,"RHEA_ID":25267,"compounds":"2-phenylacetaldehyde + H2O2 + NH4(+) => 2-phenylethylamine + H2O + O2"}
{"X":27956,"RHEA_ID":35835,"DIRECTION":"UN","MASTER_ID":35835,"ec":"1.1.1.355","compounds":"2'-dehydrokanamycin A + H(+) + NADPH = kanamycin A + NADP(+)"}
{"X":27957,"RHEA_ID":25269,"DIRECTION":"UN","MASTER_ID":25269,"ec":"2.1.1.28","compounds":"(R)-noradrenaline + S-adenosyl-L-methionine = (R)-adrenaline + H(+) + S-adenosyl-L-homocysteine"}
{"X":27958,"RHEA_ID":25270,"DIRECTION":"LR","MASTER_ID":25269,"metacyc":"RXN66-241","reactome":"R-HSA-209903.1","compounds":"(R)-noradrenaline + S-adenosyl-L-methionine => (R)-adrenaline + H(+) + S-adenosyl-L-homocysteine"}
{"X":27959,"RHEA_ID":25271,"compounds":"(R)-adrenaline + H(+) + S-adenosyl-L-homocysteine => (R)-noradrenaline + S-adenosyl-L-methionine"}
{"X":27960,"RHEA_ID":45764,"compounds":"H2O + L-aspartate 4-semialdehyde + NAD(+) = 2 H(+) + L-aspartate + NADH"}
{"X":27961,"RHEA_ID":25273,"DIRECTION":"UN","MASTER_ID":25273,"ec":"6.3.2.37","compounds":"ATP + D-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + N(6)-(UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl)-D-lysine + phosphate"}
{"X":27962,"RHEA_ID":25274,"DIRECTION":"LR","MASTER_ID":25273,"metacyc":"RXN-12042","compounds":"ATP + D-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate => ADP + H(+) + N(6)-(UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl)-D-lysine + phosphate"}
{"X":27963,"RHEA_ID":25275,"compounds":"ADP + H(+) + N(6)-(UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl)-D-lysine + phosphate => ATP + D-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate"}
{"X":27964,"RHEA_ID":45768,"compounds":"gamma-glutamyl-L-alaninol + H2O = L-alaninol + L-glutamate"}
{"X":27965,"RHEA_ID":25277,"DIRECTION":"UN","MASTER_ID":25277,"ec":"3.1.4.53","compounds":"3',5'-cyclic AMP + H2O = AMP + H(+)"}
{"X":27966,"RHEA_ID":25278,"DIRECTION":"LR","MASTER_ID":25277,"ecocyc":"RXN0-5038","metacyc":"RXN0-5038","reactome":"R-HSA-162425.4","compounds":"3',5'-cyclic AMP + H2O => AMP + H(+)"}
{"X":27967,"RHEA_ID":25278,"DIRECTION":"LR","MASTER_ID":25277,"ecocyc":"RXN0-5038","metacyc":"RXN0-5038","reactome":"R-HSA-9644869.1","compounds":"3',5'-cyclic AMP + H2O => AMP + H(+)"}
{"X":27968,"RHEA_ID":35847,"DIRECTION":"UN","MASTER_ID":35847,"ec":"2.7.1.91","compounds":"ATP + sphing-4-enine = ADP + H(+) + sphing-4-enine 1-phosphate"}
{"X":27969,"RHEA_ID":25278,"DIRECTION":"LR","MASTER_ID":25277,"ecocyc":"RXN0-5038","metacyc":"RXN0-5038","reactome":"R-HSA-9629675.1","compounds":"3',5'-cyclic AMP + H2O => AMP + H(+)"}
{"X":27970,"RHEA_ID":25278,"DIRECTION":"LR","MASTER_ID":25277,"ecocyc":"RXN0-5038","metacyc":"RXN0-5038","reactome":"R-HSA-111962.2","compounds":"3',5'-cyclic AMP + H2O => AMP + H(+)"}
{"X":27971,"RHEA_ID":25278,"DIRECTION":"LR","MASTER_ID":25277,"ecocyc":"RXN0-5038","metacyc":"RXN0-5038","reactome":"R-HSA-111955.1","compounds":"3',5'-cyclic AMP + H2O => AMP + H(+)"}
{"X":27972,"RHEA_ID":35851,"compounds":"1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":27973,"RHEA_ID":35852,"compounds":"1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":27974,"RHEA_ID":25282,"DIRECTION":"UN","MASTER_ID":25282,"ec":"1.14.14.17","compounds":"O2 + reduced [NADPH--hemoprotein reductase] + squalene = (S)-2,3-epoxysqualene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":27975,"RHEA_ID":25283,"DIRECTION":"LR","MASTER_ID":25282,"metacyc":"SQUALENE-MONOOXYGENASE-RXN","compounds":"O2 + reduced [NADPH--hemoprotein reductase] + squalene => (S)-2,3-epoxysqualene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":27976,"RHEA_ID":35855,"compounds":"1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":27977,"RHEA_ID":35856,"compounds":"1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA => 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":27978,"RHEA_ID":25286,"DIRECTION":"UN","MASTER_ID":25286,"ec":"1.14.14.154","compounds":"lanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}
{"X":27979,"RHEA_ID":25287,"DIRECTION":"LR","MASTER_ID":25286,"metacyc":"RXN3O-130","compounds":"lanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}
{"X":27980,"RHEA_ID":25288,"compounds":"4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => lanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]"}
{"X":27981,"RHEA_ID":35860,"compounds":"1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA => 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":27982,"RHEA_ID":25290,"DIRECTION":"UN","MASTER_ID":25290,"ec":"1.1.1.1","compounds":"ethanol + NAD(+) = acetaldehyde + H(+) + NADH"}
{"X":27983,"RHEA_ID":25291,"DIRECTION":"LR","MASTER_ID":25290,"reactome":"R-HSA-71707.2","compounds":"ethanol + NAD(+) => acetaldehyde + H(+) + NADH"}
{"X":27984,"RHEA_ID":25292,"compounds":"acetaldehyde + H(+) + NADH => ethanol + NAD(+)"}
{"X":27985,"RHEA_ID":25294,"DIRECTION":"UN","MASTER_ID":25294,"ec":"1.2.1.3","compounds":"acetaldehyde + H2O + NAD(+) = acetate + 2 H(+) + NADH"}
{"X":27986,"RHEA_ID":35866,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA <=> 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":27987,"RHEA_ID":25295,"DIRECTION":"LR","MASTER_ID":25294,"metacyc":"RXN66-3","reactome":"R-HSA-5696091.1","compounds":"acetaldehyde + H2O + NAD(+) => acetate + 2 H(+) + NADH"}
{"X":27988,"RHEA_ID":25295,"DIRECTION":"LR","MASTER_ID":25294,"metacyc":"RXN66-3","reactome":"R-HSA-71723.2","compounds":"acetaldehyde + H2O + NAD(+) => acetate + 2 H(+) + NADH"}
{"X":27989,"RHEA_ID":25296,"compounds":"acetate + 2 H(+) + NADH => acetaldehyde + H2O + NAD(+)"}
{"X":27990,"RHEA_ID":35870,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-D-myo-inositol + CoA"}
{"X":27991,"RHEA_ID":25298,"DIRECTION":"UN","MASTER_ID":25298,"ec":"1.2.1.4","compounds":"acetaldehyde + H2O + NADP(+) = acetate + 2 H(+) + NADPH"}
{"X":27992,"RHEA_ID":25299,"DIRECTION":"LR","MASTER_ID":25298,"ecocyc":"RXN0-3962","metacyc":"RXN0-3962","compounds":"acetaldehyde + H2O + NADP(+) => acetate + 2 H(+) + NADPH"}
{"X":27993,"RHEA_ID":25300,"compounds":"acetate + 2 H(+) + NADPH => acetaldehyde + H2O + NADP(+)"}
{"X":27994,"RHEA_ID":25302,"DIRECTION":"UN","MASTER_ID":25302,"ec":"3.6.1.67","compounds":"7,8-dihydroneopterin 3'-triphosphate + H2O = 7,8-dihydroneopterin 3'-phosphate + diphosphate + H(+)"}
{"X":27995,"RHEA_ID":25303,"DIRECTION":"LR","MASTER_ID":25302,"ecocyc":"H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN","metacyc":"H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN","compounds":"7,8-dihydroneopterin 3'-triphosphate + H2O => 7,8-dihydroneopterin 3'-phosphate + diphosphate + H(+)"}
{"X":27996,"RHEA_ID":25304,"compounds":"7,8-dihydroneopterin 3'-phosphate + diphosphate + H(+) => 7,8-dihydroneopterin 3'-triphosphate + H2O"}
{"X":27997,"RHEA_ID":45803,"DIRECTION":"BI","MASTER_ID":45800,"metacyc":"RXN-14862","compounds":"15-demethylaclacinomycin T + AH2 + O2 <=> 10-decarboxymethylaclacinomycin T + A + CO2 + H2O"}
{"X":27998,"RHEA_ID":25306,"compounds":"7,8-dihydroneopterin + phosphate = 7,8-dihydroneopterin 3'-phosphate + H2O"}
{"X":27999,"RHEA_ID":25307,"compounds":"7,8-dihydroneopterin + phosphate => 7,8-dihydroneopterin 3'-phosphate + H2O"}
{"X":28000,"RHEA_ID":25308,"DIRECTION":"RL","MASTER_ID":25306,"ecocyc":"DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN","metacyc":"DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN","compounds":"7,8-dihydroneopterin 3'-phosphate + H2O => 7,8-dihydroneopterin + phosphate"}
{"X":28001,"RHEA_ID":45807,"compounds":"ATP + hydroxylamine + L-glutamate <=> ADP + L-glutamine hydroxamate + phosphate"}
{"X":28002,"RHEA_ID":25311,"DIRECTION":"UN","MASTER_ID":25311,"ec":"1.1.3.15","compounds":"glycolate + O2 = glyoxylate + H2O2"}
{"X":28003,"RHEA_ID":25312,"DIRECTION":"LR","MASTER_ID":25311,"metacyc":"RXN-969","reactome":"R-HSA-389842.5","compounds":"glycolate + O2 => glyoxylate + H2O2"}
{"X":28004,"RHEA_ID":25313,"compounds":"glyoxylate + H2O2 => glycolate + O2"}
{"X":28005,"RHEA_ID":25315,"compounds":"2-oxoglutarate + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate = L-2-acetamido-6-oxoheptanedioate + L-glutamate"}
{"X":28006,"RHEA_ID":25316,"compounds":"2-oxoglutarate + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate => L-2-acetamido-6-oxoheptanedioate + L-glutamate"}
{"X":28007,"RHEA_ID":25317,"DIRECTION":"RL","MASTER_ID":25315,"metacyc":"RXN-4822","compounds":"L-2-acetamido-6-oxoheptanedioate + L-glutamate => 2-oxoglutarate + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate"}
{"X":28008,"RHEA_ID":25321,"DIRECTION":"UN","MASTER_ID":25321,"ec":"2.1.1.103","compounds":"N-methylethanolamine phosphate + S-adenosyl-L-methionine = H(+) + N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine"}
{"X":28009,"RHEA_ID":25322,"DIRECTION":"LR","MASTER_ID":25321,"metacyc":"RXN-5642","compounds":"N-methylethanolamine phosphate + S-adenosyl-L-methionine => H(+) + N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine"}
{"X":28010,"RHEA_ID":25323,"compounds":"H(+) + N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine => N-methylethanolamine phosphate + S-adenosyl-L-methionine"}
{"X":28011,"RHEA_ID":35894,"compounds":"(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":28012,"RHEA_ID":35895,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":28013,"RHEA_ID":25326,"DIRECTION":"LR","MASTER_ID":25325,"metacyc":"RXN-5643","compounds":"N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine => H(+) + phosphocholine + S-adenosyl-L-homocysteine"}
{"X":28014,"RHEA_ID":25327,"compounds":"H(+) + phosphocholine + S-adenosyl-L-homocysteine => N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine"}
{"X":28015,"RHEA_ID":35898,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":28016,"RHEA_ID":35899,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":28017,"RHEA_ID":25331,"compounds":"(R)-carnitine + NAD(+) => 3-dehydrocarnitine + H(+) + NADH"}
{"X":28018,"RHEA_ID":25332,"compounds":"3-dehydrocarnitine + H(+) + NADH => (R)-carnitine + NAD(+)"}
{"X":28019,"RHEA_ID":25333,"DIRECTION":"BI","MASTER_ID":25330,"metacyc":"CARNITINE-3-DEHYDROGENASE-RXN","compounds":"(R)-carnitine + NAD(+) <=> 3-dehydrocarnitine + H(+) + NADH"}
{"X":28020,"RHEA_ID":35903,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":28021,"RHEA_ID":25335,"compounds":"H2O + L-cysteinyl-tRNA(Cys) => H(+) + L-cysteine + tRNA(Cys)"}
{"X":28022,"RHEA_ID":39234,"compounds":"3-oxo-triacontanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxytriacontanoyl-CoA + NADP(+)"}
{"X":28023,"RHEA_ID":25337,"compounds":"H2O + L-cysteinyl-tRNA(Cys) <=> H(+) + L-cysteine + tRNA(Cys)"}
{"X":28024,"RHEA_ID":35907,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":28025,"RHEA_ID":25339,"compounds":"H(+) + urea => isocyanate + NH4(+)"}
{"X":28026,"RHEA_ID":25340,"compounds":"isocyanate + NH4(+) => H(+) + urea"}
{"X":28027,"RHEA_ID":25341,"compounds":"H(+) + urea <=> isocyanate + NH4(+)"}
{"X":28028,"RHEA_ID":35911,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA"}
{"X":28029,"RHEA_ID":25343,"compounds":"H2O + urea => carbamate + NH4(+)"}
{"X":28030,"RHEA_ID":25344,"compounds":"carbamate + NH4(+) => H2O + urea"}
{"X":28031,"RHEA_ID":25345,"compounds":"H2O + urea <=> carbamate + NH4(+)"}
{"X":28032,"RHEA_ID":35915,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":28033,"RHEA_ID":25348,"compounds":"D-tyrosyl-tRNA(Tyr) + H2O => D-tyrosine + tRNA(Tyr)"}
{"X":28034,"RHEA_ID":25349,"compounds":"D-tyrosine + tRNA(Tyr) => D-tyrosyl-tRNA(Tyr) + H2O"}
{"X":28035,"RHEA_ID":25350,"compounds":"D-tyrosyl-tRNA(Tyr) + H2O <=> D-tyrosine + tRNA(Tyr)"}
{"X":28036,"RHEA_ID":25351,"DIRECTION":"UN","MASTER_ID":25351,"ec":"3.6.1.n2","compounds":"H2O + L-cysteinyl-tRNA(Pro) = H(+) + L-cysteine + tRNA(Pro)"}
{"X":28037,"RHEA_ID":25352,"compounds":"H2O + L-cysteinyl-tRNA(Pro) => H(+) + L-cysteine + tRNA(Pro)"}
{"X":28038,"RHEA_ID":25353,"compounds":"H(+) + L-cysteine + tRNA(Pro) => H2O + L-cysteinyl-tRNA(Pro)"}
{"X":28039,"RHEA_ID":25354,"compounds":"H2O + L-cysteinyl-tRNA(Pro) <=> H(+) + L-cysteine + tRNA(Pro)"}
{"X":28040,"RHEA_ID":25355,"DIRECTION":"UN","MASTER_ID":25355,"ec":"4.1.2.n2","compounds":"2-hydroxyphytanoyl-CoA = 2,6,10,14-tetramethylpentadecanal + formyl-CoA"}
{"X":28041,"RHEA_ID":25356,"DIRECTION":"LR","MASTER_ID":25355,"metacyc":"RXN-14104","reactome":"R-HSA-389611.1","compounds":"2-hydroxyphytanoyl-CoA => 2,6,10,14-tetramethylpentadecanal + formyl-CoA"}
{"X":28042,"RHEA_ID":25357,"compounds":"2,6,10,14-tetramethylpentadecanal + formyl-CoA => 2-hydroxyphytanoyl-CoA"}
{"X":28043,"RHEA_ID":25358,"compounds":"2-hydroxyphytanoyl-CoA <=> 2,6,10,14-tetramethylpentadecanal + formyl-CoA"}
{"X":28044,"RHEA_ID":35927,"compounds":"paromamine + UDP-alpha-D-glucose = 3''-deamino-3''-hydroxykanamycin C + H(+) + UDP"}
{"X":28045,"RHEA_ID":25360,"compounds":"(3Z)-phycoerythrobilin + 2 oxidized 2[4Fe-4S]-[ferredoxin] => biliverdin IXalpha + 4 H(+) + 2 reduced 2[4Fe-4S]-[ferredoxin]"}
{"X":28046,"RHEA_ID":25361,"DIRECTION":"RL","MASTER_ID":25359,"metacyc":"RXN-9292","compounds":"biliverdin IXalpha + 4 H(+) + 2 reduced 2[4Fe-4S]-[ferredoxin] => (3Z)-phycoerythrobilin + 2 oxidized 2[4Fe-4S]-[ferredoxin]"}
{"X":28047,"RHEA_ID":35930,"compounds":"paromamine + UDP-alpha-D-glucose <=> 3''-deamino-3''-hydroxykanamycin C + H(+) + UDP"}
{"X":28048,"RHEA_ID":35931,"compounds":"2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-glucose = 3''-deamino-3''-hydroxykanamycin X + H(+) + UDP"}
{"X":28049,"RHEA_ID":25364,"DIRECTION":"LR","MASTER_ID":25363,"metacyc":"RXN-9290","compounds":"3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NAD(+) => H(+) + momilactone A + NADH"}
{"X":28050,"RHEA_ID":25365,"compounds":"H(+) + momilactone A + NADH => 3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NAD(+)"}
{"X":28051,"RHEA_ID":35934,"compounds":"2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-glucose <=> 3''-deamino-3''-hydroxykanamycin X + H(+) + UDP"}
{"X":28052,"RHEA_ID":35935,"compounds":"2 ATP + L-proline + L-tryptophan = 2 AMP + brevianamide F + 2 diphosphate + 2 H(+)"}
{"X":28053,"RHEA_ID":25368,"DIRECTION":"LR","MASTER_ID":25367,"metacyc":"RXN-9290","compounds":"3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NADP(+) => H(+) + momilactone A + NADPH"}
{"X":28054,"RHEA_ID":25369,"compounds":"H(+) + momilactone A + NADPH => 3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NADP(+)"}
{"X":28055,"RHEA_ID":35938,"DIRECTION":"BI","MASTER_ID":35935,"metacyc":"RXN-15642","compounds":"2 ATP + L-proline + L-tryptophan <=> 2 AMP + brevianamide F + 2 diphosphate + 2 H(+)"}
{"X":28056,"RHEA_ID":25371,"DIRECTION":"UN","MASTER_ID":25371,"ec":"1.3.99.24","compounds":"(2S)-2-amino-4-deoxychorismate + FMN = 3-(1-carboxyvinyloxy)anthranilate + FMNH2"}
{"X":28057,"RHEA_ID":25372,"compounds":"(2S)-2-amino-4-deoxychorismate + FMN => 3-(1-carboxyvinyloxy)anthranilate + FMNH2"}
{"X":28058,"RHEA_ID":35941,"compounds":"diphosphate + tryprostatin B => brevianamide F + dimethylallyl diphosphate"}
{"X":28059,"RHEA_ID":45867,"compounds":"16-hydroxyhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(15-hydroxypentadecyl)-pyran-2-one + 2 CO2 + 3 CoA"}
{"X":28060,"RHEA_ID":25375,"DIRECTION":"UN","MASTER_ID":25375,"ec":"4.1.2.n2","compounds":"2-hydroxy-3-methyl fatty acyl-CoA = 2-methyl-branched fatty aldehyde + formyl-CoA"}
{"X":28061,"RHEA_ID":25376,"compounds":"2-hydroxy-3-methyl fatty acyl-CoA => 2-methyl-branched fatty aldehyde + formyl-CoA"}
{"X":28062,"RHEA_ID":35945,"compounds":"deoxybrevianamide E + diphosphate => brevianamide F + dimethylallyl diphosphate"}
{"X":28063,"RHEA_ID":25378,"compounds":"2-hydroxy-3-methyl fatty acyl-CoA <=> 2-methyl-branched fatty aldehyde + formyl-CoA"}
{"X":28064,"RHEA_ID":25379,"DIRECTION":"UN","MASTER_ID":25379,"ec":"4.1.2.n2","metacyc":"RXN-14105","compounds":"2-hydroxy-3-methylhexadecanoyl-CoA = 2-methylpentadecanal + formyl-CoA"}
{"X":28065,"RHEA_ID":25380,"compounds":"2-hydroxy-3-methylhexadecanoyl-CoA => 2-methylpentadecanal + formyl-CoA"}
{"X":28066,"RHEA_ID":35949,"DIRECTION":"RL","MASTER_ID":35947,"metacyc":"RXN-13476","compounds":"chanoclavine-I aldehyde + H(+) + NADPH => dihydrochanoclavine-I aldehyde + NADP(+)"}
{"X":28067,"RHEA_ID":25382,"compounds":"2-hydroxy-3-methylhexadecanoyl-CoA <=> 2-methylpentadecanal + formyl-CoA"}
{"X":28068,"RHEA_ID":25391,"DIRECTION":"UN","MASTER_ID":25391,"ec":"1.2.1.77","compounds":"(3Z)-6-oxohex-3-enoyl-CoA + H2O + NADP(+) = cis-3,4-dehydroadipyl-CoA + 2 H(+) + NADPH"}
{"X":28069,"RHEA_ID":25392,"DIRECTION":"LR","MASTER_ID":25391,"metacyc":"RXN-11053","compounds":"(3Z)-6-oxohex-3-enoyl-CoA + H2O + NADP(+) => cis-3,4-dehydroadipyl-CoA + 2 H(+) + NADPH"}
{"X":28070,"RHEA_ID":35953,"compounds":"diphosphate + N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate => (7,8-dihydropterin-6-yl)methyl diphosphate + 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate"}
{"X":28071,"RHEA_ID":45879,"compounds":"2-methylhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 6-(hexadecan-2-yl)-4-hydroxy-pyran-2-one + 2 CO2 + 3 CoA"}
{"X":28072,"RHEA_ID":25395,"DIRECTION":"UN","MASTER_ID":25395,"ec":"1.13.11.60","compounds":"(9Z,12Z)-octadecadienoate + O2 = (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate"}
{"X":28073,"RHEA_ID":25396,"DIRECTION":"LR","MASTER_ID":25395,"metacyc":"RXN-12756","compounds":"(9Z,12Z)-octadecadienoate + O2 => (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate"}
{"X":28074,"RHEA_ID":35957,"compounds":"6-hydroxytryprostatin B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin B"}
{"X":28075,"RHEA_ID":45883,"compounds":"3-methylundecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(2-methyldecyl)-pyran-2-one + 2 CO2 + 3 CoA"}
{"X":28076,"RHEA_ID":25399,"DIRECTION":"UN","MASTER_ID":25399,"ec":"5.4.4.6","compounds":"(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate = (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate"}
{"X":28077,"RHEA_ID":25400,"compounds":"(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate => (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate"}
{"X":28078,"RHEA_ID":35961,"compounds":"demethoxyfumitremorgin C + 2 H2O + NADP(+) => H(+) + NADPH + O2 + tryprostatin B"}
{"X":28079,"RHEA_ID":35962,"compounds":"H(+) + NADPH + O2 + tryprostatin B <=> demethoxyfumitremorgin C + 2 H2O + NADP(+)"}
{"X":28080,"RHEA_ID":25404,"DIRECTION":"UN","MASTER_ID":25404,"ec":"5.4.99.3","compounds":"(S)-2-ethyl-2-hydroxy-3-oxobutanoate = (R)-3-hydroxy-3-methyl-2-oxopentanoate"}
{"X":28081,"RHEA_ID":25405,"compounds":"(S)-2-ethyl-2-hydroxy-3-oxobutanoate => (R)-3-hydroxy-3-methyl-2-oxopentanoate"}
{"X":28082,"RHEA_ID":35965,"compounds":"fumitremorgin C + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin A"}
{"X":28083,"RHEA_ID":45891,"compounds":"12-methyltridecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(11-methyldodecyl)-pyran-2-one + 2 CO2 + 3 CoA"}
{"X":28084,"RHEA_ID":25408,"DIRECTION":"UN","MASTER_ID":25408,"ec":"2.4.1.245","compounds":"ADP-alpha-D-glucose + D-glucose = ADP + alpha,alpha-trehalose + H(+)"}
{"X":28085,"RHEA_ID":25409,"compounds":"ADP-alpha-D-glucose + D-glucose => ADP + alpha,alpha-trehalose + H(+)"}
{"X":28086,"RHEA_ID":35969,"compounds":"12alpha,13alpha-dihydroxyfumitremorgin C + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => fumitremorgin C + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}
{"X":28087,"RHEA_ID":25411,"compounds":"ADP-alpha-D-glucose + D-glucose <=> ADP + alpha,alpha-trehalose + H(+)"}
{"X":28088,"RHEA_ID":25416,"compounds":"AH2 + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + A + 2 H2O"}
{"X":28089,"RHEA_ID":25417,"compounds":"AH2 + O2 + octadecanoyl-CoA => (9Z)-octadecenoyl-CoA + A + 2 H2O"}
{"X":28090,"RHEA_ID":25418,"compounds":"(9Z)-octadecenoyl-CoA + A + 2 H2O => AH2 + O2 + octadecanoyl-CoA"}
{"X":28091,"RHEA_ID":25419,"compounds":"AH2 + O2 + octadecanoyl-CoA <=> (9Z)-octadecenoyl-CoA + A + 2 H2O"}
{"X":28092,"RHEA_ID":25420,"DIRECTION":"UN","MASTER_ID":25420,"ec":"1.3.99.n1","compounds":"3-hydroxybenzoyl-CoA + AH2 + 2 ATP + 2 H2O = 3-hydroxycyclohexa-1,5-diene-1-carbonyl-CoA + A + 2 ADP + 2 H(+) + 2 phosphate"}
{"X":28093,"RHEA_ID":25421,"compounds":"3-hydroxybenzoyl-CoA + AH2 + 2 ATP + 2 H2O => 3-hydroxycyclohexa-1,5-diene-1-carbonyl-CoA + A + 2 ADP + 2 H(+) + 2 phosphate"}
{"X":28094,"RHEA_ID":35977,"compounds":"A + CO2 + H2O + succinate + verruculogen => 2-oxoglutarate + AH2 + fumitremorgin B + 2 O2"}
{"X":28095,"RHEA_ID":25423,"compounds":"3-hydroxybenzoyl-CoA + AH2 + 2 ATP + 2 H2O <=> 3-hydroxycyclohexa-1,5-diene-1-carbonyl-CoA + A + 2 ADP + 2 H(+) + 2 phosphate"}
{"X":28096,"RHEA_ID":25424,"DIRECTION":"UN","MASTER_ID":25424,"ec":"2.4.2.8","compounds":"diphosphate + GMP = 5-phospho-alpha-D-ribose 1-diphosphate + guanine"}
{"X":28097,"RHEA_ID":25425,"compounds":"diphosphate + GMP => 5-phospho-alpha-D-ribose 1-diphosphate + guanine"}
{"X":28098,"RHEA_ID":35981,"compounds":"diphosphate + fumitremorgin A => dimethylallyl diphosphate + verruculogen"}
{"X":28099,"RHEA_ID":45907,"compounds":"devancoaminyl-vancomycin + dTDP-beta-L-vancosamine <=> dTDP + epivancomycin + H(+)"}
{"X":28100,"RHEA_ID":25428,"DIRECTION":"UN","MASTER_ID":25428,"ec":"2.7.1.162","compounds":"ATP + N-acetyl-D-hexosamine = ADP + H(+) + N-acetyl-alpha-D-hexosamine 1-phosphate"}
{"X":28101,"RHEA_ID":25429,"compounds":"ATP + N-acetyl-D-hexosamine => ADP + H(+) + N-acetyl-alpha-D-hexosamine 1-phosphate"}
{"X":28102,"RHEA_ID":35985,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA"}
{"X":28103,"RHEA_ID":35986,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":28104,"RHEA_ID":25432,"DIRECTION":"UN","MASTER_ID":25432,"ec":"5.4.99.62","compounds":"beta-D-ribopyranose = beta-D-ribofuranose"}
{"X":28105,"RHEA_ID":25433,"compounds":"beta-D-ribopyranose => beta-D-ribofuranose"}
{"X":28106,"RHEA_ID":25434,"compounds":"beta-D-ribofuranose => beta-D-ribopyranose"}
{"X":28107,"RHEA_ID":35990,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA <=> 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":28108,"RHEA_ID":25436,"DIRECTION":"UN","MASTER_ID":25436,"ec":"4.2.3.38","compounds":"(2E,6E)-farnesyl diphosphate = (E,R)-alpha-bisabolene + diphosphate"}
{"X":28109,"RHEA_ID":25437,"DIRECTION":"LR","MASTER_ID":25436,"metacyc":"RXN-8550","compounds":"(2E,6E)-farnesyl diphosphate => (E,R)-alpha-bisabolene + diphosphate"}
{"X":28110,"RHEA_ID":35993,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":28111,"RHEA_ID":35994,"compounds":"(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":28112,"RHEA_ID":25440,"DIRECTION":"UN","MASTER_ID":25440,"ec":"4.2.3.n2","compounds":"(2E,6E)-farnesyl diphosphate = delta-selinene + diphosphate"}
{"X":28113,"RHEA_ID":25441,"compounds":"(2E,6E)-farnesyl diphosphate => delta-selinene + diphosphate"}
{"X":28114,"RHEA_ID":35997,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":28115,"RHEA_ID":25443,"compounds":"(2E,6E)-farnesyl diphosphate <=> delta-selinene + diphosphate"}
{"X":28116,"RHEA_ID":25444,"DIRECTION":"UN","MASTER_ID":25444,"ec":"4.2.3.n2","compounds":"(2E,6E)-farnesyl diphosphate = (1E,4E)-germacrene B + diphosphate"}
{"X":28117,"RHEA_ID":25444,"DIRECTION":"UN","MASTER_ID":25444,"ec":"4.2.3.71","compounds":"(2E,6E)-farnesyl diphosphate = (1E,4E)-germacrene B + diphosphate"}
{"X":28118,"RHEA_ID":36001,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":28119,"RHEA_ID":25446,"compounds":"(1E,4E)-germacrene B + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":28120,"RHEA_ID":36003,"DIRECTION":"UN","MASTER_ID":36003,"ec":"4.1.3.43","compounds":"(S)-4-hydroxy-2-oxohexanoate = propanal + pyruvate"}
{"X":28121,"RHEA_ID":25448,"DIRECTION":"UN","MASTER_ID":25448,"ec":"4.2.3.n2","compounds":"(2E,6E)-farnesyl diphosphate = (+)-guaia-6,9-diene + diphosphate"}
{"X":28122,"RHEA_ID":36005,"compounds":"propanal + pyruvate => (S)-4-hydroxy-2-oxohexanoate"}
{"X":28123,"RHEA_ID":25450,"compounds":"(+)-guaia-6,9-diene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":28124,"RHEA_ID":25451,"compounds":"(2E,6E)-farnesyl diphosphate <=> (+)-guaia-6,9-diene + diphosphate"}
{"X":28125,"RHEA_ID":25452,"DIRECTION":"UN","MASTER_ID":25452,"ec":"4.2.3.n2","compounds":"(2E,6E)-farnesyl diphosphate = diphosphate + germacrene A"}
{"X":28126,"RHEA_ID":36009,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA"}
{"X":28127,"RHEA_ID":25454,"compounds":"diphosphate + germacrene A => (2E,6E)-farnesyl diphosphate"}
{"X":28128,"RHEA_ID":25455,"compounds":"(2E,6E)-farnesyl diphosphate <=> diphosphate + germacrene A"}
{"X":28129,"RHEA_ID":25456,"DIRECTION":"UN","MASTER_ID":25456,"ec":"4.2.3.56","compounds":"(2E,6E)-farnesyl diphosphate = diphosphate + gamma-humulene"}
{"X":28130,"RHEA_ID":36013,"compounds":"1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA"}
{"X":28131,"RHEA_ID":25458,"compounds":"diphosphate + gamma-humulene => (2E,6E)-farnesyl diphosphate"}
{"X":28132,"RHEA_ID":36015,"compounds":"(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":28133,"RHEA_ID":25460,"DIRECTION":"UN","MASTER_ID":25460,"ec":"4.2.3.56","compounds":"(2E,6E)-farnesyl diphosphate = diphosphate + sibirene"}
{"X":28134,"RHEA_ID":36017,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":28135,"RHEA_ID":25462,"compounds":"diphosphate + sibirene => (2E,6E)-farnesyl diphosphate"}
{"X":28136,"RHEA_ID":25463,"compounds":"(2E,6E)-farnesyl diphosphate <=> diphosphate + sibirene"}
{"X":28137,"RHEA_ID":25464,"DIRECTION":"UN","MASTER_ID":25464,"ec":"4.2.3.56","compounds":"(2E,6E)-farnesyl diphosphate = diphosphate + longifolene"}
{"X":28138,"RHEA_ID":36021,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":28139,"RHEA_ID":36022,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":28140,"RHEA_ID":25466,"compounds":"diphosphate + longifolene => (2E,6E)-farnesyl diphosphate"}
{"X":28141,"RHEA_ID":36024,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":28142,"RHEA_ID":25468,"DIRECTION":"UN","MASTER_ID":25468,"ec":"4.2.3.56","compounds":"(2E,6E)-farnesyl diphosphate = beta-himachalene + diphosphate"}
{"X":28143,"RHEA_ID":25469,"DIRECTION":"LR","MASTER_ID":25468,"metacyc":"RXN-8544","compounds":"(2E,6E)-farnesyl diphosphate => beta-himachalene + diphosphate"}
{"X":28144,"RHEA_ID":25470,"compounds":"beta-himachalene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":28145,"RHEA_ID":25471,"compounds":"(2E,6E)-farnesyl diphosphate <=> beta-himachalene + diphosphate"}
{"X":28146,"RHEA_ID":25472,"DIRECTION":"UN","MASTER_ID":25472,"ec":"4.2.3.56","compounds":"(2E,6E)-farnesyl diphosphate = diphosphate + gamma-himachalene"}
{"X":28147,"RHEA_ID":45955,"compounds":"L-asparaginyl-[protein] + UDP-alpha-D-glucose <=> H(+) + N(4)-(beta-D-glucosyl)-L-asparaginyl-[protein] + UDP"}
{"X":28148,"RHEA_ID":25474,"compounds":"diphosphate + gamma-himachalene => (2E,6E)-farnesyl diphosphate"}
{"X":28149,"RHEA_ID":25475,"compounds":"(2E,6E)-farnesyl diphosphate <=> diphosphate + gamma-himachalene"}
{"X":28150,"RHEA_ID":25476,"DIRECTION":"UN","MASTER_ID":25476,"ec":"4.2.3.56","compounds":"(2E,6E)-farnesyl diphosphate = alpha-himachalene + diphosphate"}
{"X":28151,"RHEA_ID":45959,"compounds":"(9Z)-octadecenoyl-CoA(in) <=> (9Z)-octadecenoyl-CoA(out)"}
{"X":28152,"RHEA_ID":25478,"compounds":"alpha-himachalene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":28153,"RHEA_ID":25479,"compounds":"(2E,6E)-farnesyl diphosphate <=> alpha-himachalene + diphosphate"}
{"X":28154,"RHEA_ID":25480,"DIRECTION":"UN","MASTER_ID":25480,"ec":"2.8.3.5","compounds":"acetoacetate + succinyl-CoA = acetoacetyl-CoA + succinate"}
{"X":28155,"RHEA_ID":25481,"DIRECTION":"LR","MASTER_ID":25480,"reactome":"R-HSA-74177.3","compounds":"acetoacetate + succinyl-CoA => acetoacetyl-CoA + succinate"}
{"X":28156,"RHEA_ID":25482,"compounds":"acetoacetyl-CoA + succinate => acetoacetate + succinyl-CoA"}
{"X":28157,"RHEA_ID":36044,"DIRECTION":"LR","MASTER_ID":36043,"metacyc":"RXN-14333","compounds":"all-trans-8'-apo-beta-carotenal + O2 => 13-apo-beta-carotenone + 2,6-dimethyldeca-2,4,6,8-tetraenedial"}
{"X":28158,"RHEA_ID":25484,"DIRECTION":"UN","MASTER_ID":25484,"ec":"4.2.3.117","compounds":"(2E)-geranyl diphosphate = (1S,4R)-camphene + diphosphate"}
{"X":28159,"RHEA_ID":45967,"compounds":"5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 H2O <=> 2 AMP + ATP + 2 H(+)"}
{"X":28160,"RHEA_ID":25486,"compounds":"(1S,4R)-camphene + diphosphate => (2E)-geranyl diphosphate"}
{"X":28161,"RHEA_ID":36048,"DIRECTION":"LR","MASTER_ID":36047,"metacyc":"GLYCERALDEHYDE-DEHYDRO-RXN","compounds":"A + D-glyceraldehyde + H2O => (R)-glycerate + AH2 + H(+)"}
{"X":28162,"RHEA_ID":25488,"DIRECTION":"UN","MASTER_ID":25488,"ec":"4.2.3.119","compounds":"(2E)-geranyl diphosphate = (1S,5S)-alpha-pinene + diphosphate"}
{"X":28163,"RHEA_ID":25489,"DIRECTION":"LR","MASTER_ID":25488,"metacyc":"RXN-5106","compounds":"(2E)-geranyl diphosphate => (1S,5S)-alpha-pinene + diphosphate"}
{"X":28164,"RHEA_ID":25490,"compounds":"(1S,5S)-alpha-pinene + diphosphate => (2E)-geranyl diphosphate"}
{"X":28165,"RHEA_ID":36052,"DIRECTION":"LR","MASTER_ID":36051,"metacyc":"RXN-14089","compounds":"beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose + H2O => 2 beta-L-arabinofuranose"}
{"X":28166,"RHEA_ID":25492,"DIRECTION":"UN","MASTER_ID":25492,"ec":"4.2.3.52","compounds":"(2E)-geranyl diphosphate = (-)-beta-phellandrene + diphosphate"}
{"X":28167,"RHEA_ID":45975,"compounds":"3-oxochol-4-en-22-oate + H(+) + NADH + O2 <=> 9alpha-hydroxy-3-oxochol-4-en-22-oate + H2O + NAD(+)"}
{"X":28168,"RHEA_ID":25494,"compounds":"(-)-beta-phellandrene + diphosphate => (2E)-geranyl diphosphate"}
{"X":28169,"RHEA_ID":25495,"compounds":"(2E)-geranyl diphosphate <=> (-)-beta-phellandrene + diphosphate"}
{"X":28170,"RHEA_ID":25496,"DIRECTION":"UN","MASTER_ID":25496,"ec":"4.2.3.120","compounds":"(2E)-geranyl diphosphate = (1S,5S)-beta-pinene + diphosphate"}
{"X":28171,"RHEA_ID":25497,"DIRECTION":"LR","MASTER_ID":25496,"metacyc":"RXN-5107","compounds":"(2E)-geranyl diphosphate => (1S,5S)-beta-pinene + diphosphate"}
{"X":28172,"RHEA_ID":36059,"DIRECTION":"UN","MASTER_ID":36059,"ec":"1.3.99.33","compounds":"A + dihydrourocanate = AH2 + urocanate"}
{"X":28173,"RHEA_ID":36060,"compounds":"A + dihydrourocanate => AH2 + urocanate"}
{"X":28174,"RHEA_ID":25500,"DIRECTION":"UN","MASTER_ID":25500,"ec":"4.2.3.113","compounds":"(2E)-geranyl diphosphate = diphosphate + terpinolene"}
{"X":28175,"RHEA_ID":25501,"DIRECTION":"LR","MASTER_ID":25500,"metacyc":"RXN-5108","compounds":"(2E)-geranyl diphosphate => diphosphate + terpinolene"}
{"X":28176,"RHEA_ID":36063,"DIRECTION":"UN","MASTER_ID":36063,"ec":"4.2.3.143","compounds":"(2E,6E)-farnesyl diphosphate + H2O = diphosphate + kunzeaol"}
{"X":28177,"RHEA_ID":36064,"DIRECTION":"LR","MASTER_ID":36063,"metacyc":"RXN-14375","compounds":"(2E,6E)-farnesyl diphosphate + H2O => diphosphate + kunzeaol"}
{"X":28178,"RHEA_ID":25504,"compounds":"(2E)-geranyl diphosphate = beta-phellandrene + diphosphate"}
{"X":28179,"RHEA_ID":25505,"compounds":"(2E)-geranyl diphosphate => beta-phellandrene + diphosphate"}
{"X":28180,"RHEA_ID":36067,"DIRECTION":"UN","MASTER_ID":36067,"ec":"2.1.1.196","compounds":"Co-precorrin-6B + S-adenosyl-L-methionine = Co-precorrin-7 + CO2 + S-adenosyl-L-homocysteine"}
{"X":28181,"RHEA_ID":25507,"compounds":"(2E)-geranyl diphosphate <=> beta-phellandrene + diphosphate"}
{"X":28182,"RHEA_ID":25508,"DIRECTION":"UN","MASTER_ID":25508,"ec":"4.2.3.109","compounds":"(2E)-geranyl diphosphate = (1S,5S)-sabinene + diphosphate"}
{"X":28183,"RHEA_ID":25509,"DIRECTION":"LR","MASTER_ID":25508,"metacyc":"RXN-12981","compounds":"(2E)-geranyl diphosphate => (1S,5S)-sabinene + diphosphate"}
{"X":28184,"RHEA_ID":36071,"DIRECTION":"UN","MASTER_ID":36071,"ec":"4.2.99.22","compounds":"6-tuliposide A = D-glucose + tulipalin A"}
{"X":28185,"RHEA_ID":36072,"compounds":"6-tuliposide A => D-glucose + tulipalin A"}
{"X":28186,"RHEA_ID":25512,"DIRECTION":"UN","MASTER_ID":25512,"ec":"2.6.1.86","compounds":"(2S)-2-amino-4-deoxychorismate + L-glutamate = chorismate + L-glutamine"}
{"X":28187,"RHEA_ID":25513,"compounds":"(2S)-2-amino-4-deoxychorismate + L-glutamate => chorismate + L-glutamine"}
{"X":28188,"RHEA_ID":36075,"compounds":"AH2 + an N-acylsphinganine + O2 = A + an N-acylsphing-4-enine + 2 H2O"}
{"X":28189,"RHEA_ID":36076,"compounds":"AH2 + an N-acylsphinganine + O2 => A + an N-acylsphing-4-enine + 2 H2O"}
{"X":28190,"RHEA_ID":25516,"DIRECTION":"UN","MASTER_ID":25516,"ec":"2.3.1.185","compounds":"an acyl-CoA + tropine = CoA + H(+) + O-acyltropine"}
{"X":28191,"RHEA_ID":25517,"DIRECTION":"LR","MASTER_ID":25516,"metacyc":"RXN-9294","compounds":"an acyl-CoA + tropine => CoA + H(+) + O-acyltropine"}
{"X":28192,"RHEA_ID":25518,"compounds":"CoA + H(+) + O-acyltropine => an acyl-CoA + tropine"}
{"X":28193,"RHEA_ID":36080,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine => a 1,2-diacyl-sn-glycerol + N-acylsphing-4-enine 1-phosphoethanolamine"}
{"X":28194,"RHEA_ID":25520,"DIRECTION":"UN","MASTER_ID":25520,"ec":"2.3.1.186","compounds":"an acyl-CoA + pseudotropine = CoA + H(+) + O-acylpseudotropine"}
{"X":28195,"RHEA_ID":25521,"DIRECTION":"LR","MASTER_ID":25520,"metacyc":"RXN-9295","compounds":"an acyl-CoA + pseudotropine => CoA + H(+) + O-acylpseudotropine"}
{"X":28196,"RHEA_ID":36083,"compounds":"1-O-alkyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycerol + H(+) + phosphocholine"}
{"X":28197,"RHEA_ID":36084,"compounds":"1-O-alkyl-sn-glycero-3-phosphocholine + H2O => 1-O-alkyl-sn-glycerol + H(+) + phosphocholine"}
{"X":28198,"RHEA_ID":25524,"DIRECTION":"UN","MASTER_ID":25524,"ec":"5.5.1.14","compounds":"all-trans-geranylgeranyl diphosphate = 9alpha-copalyl diphosphate"}
{"X":28199,"RHEA_ID":25525,"DIRECTION":"LR","MASTER_ID":25524,"metacyc":"RXN-8528","compounds":"all-trans-geranylgeranyl diphosphate => 9alpha-copalyl diphosphate"}
{"X":28200,"RHEA_ID":25526,"compounds":"9alpha-copalyl diphosphate => all-trans-geranylgeranyl diphosphate"}
{"X":28201,"RHEA_ID":36088,"compounds":"1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycerol + H(+) + phosphocholine"}
{"X":28202,"RHEA_ID":25528,"DIRECTION":"UN","MASTER_ID":25528,"ec":"3.1.3.86","compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate"}
{"X":28203,"RHEA_ID":25529,"DIRECTION":"LR","MASTER_ID":25528,"metacyc":"RXN-10036","compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate"}
{"X":28204,"RHEA_ID":36095,"DIRECTION":"UN","MASTER_ID":36095,"ec":"2.1.1.274","compounds":"S-adenosyl-L-methionine + salicylate = methyl salicylate + S-adenosyl-L-homocysteine"}
{"X":28205,"RHEA_ID":25532,"DIRECTION":"UN","MASTER_ID":25532,"ec":"4.2.3.28","compounds":"ent-copalyl diphosphate = diphosphate + ent-cassa-12,15-diene"}
{"X":28206,"RHEA_ID":25533,"DIRECTION":"LR","MASTER_ID":25532,"metacyc":"RXN-4881","compounds":"ent-copalyl diphosphate => diphosphate + ent-cassa-12,15-diene"}
{"X":28207,"RHEA_ID":36099,"DIRECTION":"UN","MASTER_ID":36099,"ec":"2.1.1.273","compounds":"benzoate + S-adenosyl-L-methionine = methyl benzoate + S-adenosyl-L-homocysteine"}
{"X":28208,"RHEA_ID":36100,"DIRECTION":"LR","MASTER_ID":36099,"metacyc":"RXN-6722","compounds":"benzoate + S-adenosyl-L-methionine => methyl benzoate + S-adenosyl-L-homocysteine"}
{"X":28209,"RHEA_ID":25536,"DIRECTION":"UN","MASTER_ID":25536,"ec":"4.2.3.29","compounds":"ent-copalyl diphosphate = diphosphate + ent-sandaracopimara-8(14),15-diene"}
{"X":28210,"RHEA_ID":25537,"DIRECTION":"LR","MASTER_ID":25536,"metacyc":"RXN-4884","compounds":"ent-copalyl diphosphate => diphosphate + ent-sandaracopimara-8(14),15-diene"}
{"X":28211,"RHEA_ID":25538,"compounds":"diphosphate + ent-sandaracopimara-8(14),15-diene => ent-copalyl diphosphate"}
{"X":28212,"RHEA_ID":36104,"DIRECTION":"LR","MASTER_ID":36103,"metacyc":"RXN-14453","compounds":"anthranilate + S-adenosyl-L-methionine => O-methyl anthranilate + S-adenosyl-L-homocysteine"}
{"X":28213,"RHEA_ID":25540,"DIRECTION":"UN","MASTER_ID":25540,"ec":"4.2.3.30","compounds":"ent-copalyl diphosphate = diphosphate + ent-pimara-8(14),15-diene"}
{"X":28214,"RHEA_ID":25541,"DIRECTION":"LR","MASTER_ID":25540,"metacyc":"RXN-7788","compounds":"ent-copalyl diphosphate => diphosphate + ent-pimara-8(14),15-diene"}
{"X":28215,"RHEA_ID":25542,"compounds":"diphosphate + ent-pimara-8(14),15-diene => ent-copalyl diphosphate"}
{"X":28216,"RHEA_ID":36107,"DIRECTION":"UN","MASTER_ID":36107,"ec":"2.1.1.275","compounds":"gibberellin A4 + S-adenosyl-L-methionine = O-methyl gibberellin A4 + S-adenosyl-L-homocysteine"}
{"X":28217,"RHEA_ID":25544,"DIRECTION":"UN","MASTER_ID":25544,"ec":"4.2.3.31","compounds":"ent-copalyl diphosphate = diphosphate + ent-pimara-9(11),15-diene"}
{"X":28218,"RHEA_ID":25545,"DIRECTION":"LR","MASTER_ID":25544,"metacyc":"RXN-9299","compounds":"ent-copalyl diphosphate => diphosphate + ent-pimara-9(11),15-diene"}
{"X":28219,"RHEA_ID":46028,"DIRECTION":"UN","MASTER_ID":46028,"ec":"1.11.2.4","compounds":"H2O2 + tetradecanoate = (2R)-hydroxytetradecanoate + H2O"}
{"X":28220,"RHEA_ID":36111,"compounds":"gibberellin A1 + S-adenosyl-L-methionine = O-methyl gibberellin A1 + S-adenosyl-L-homocysteine"}
{"X":28221,"RHEA_ID":25548,"DIRECTION":"UN","MASTER_ID":25548,"ec":"4.2.3.32","compounds":"(+)-copalyl diphosphate = abieta-8(14),12-diene + diphosphate"}
{"X":28222,"RHEA_ID":25549,"DIRECTION":"LR","MASTER_ID":25548,"metacyc":"RXN-8511","compounds":"(+)-copalyl diphosphate => abieta-8(14),12-diene + diphosphate"}
{"X":28223,"RHEA_ID":25550,"compounds":"abieta-8(14),12-diene + diphosphate => (+)-copalyl diphosphate"}
{"X":28224,"RHEA_ID":36115,"DIRECTION":"UN","MASTER_ID":36115,"ec":"2.1.1.275","compounds":"gibberellin A3 + S-adenosyl-L-methionine = O-methyl gibberellin A3 + S-adenosyl-L-homocysteine"}
{"X":28225,"RHEA_ID":25552,"DIRECTION":"UN","MASTER_ID":25552,"ec":"4.2.3.33","compounds":"9alpha-copalyl diphosphate = diphosphate + stemar-13-ene"}
{"X":28226,"RHEA_ID":25553,"DIRECTION":"LR","MASTER_ID":25552,"metacyc":"RXN-4882","compounds":"9alpha-copalyl diphosphate => diphosphate + stemar-13-ene"}
{"X":28227,"RHEA_ID":36117,"compounds":"O-methyl gibberellin A3 + S-adenosyl-L-homocysteine => gibberellin A3 + S-adenosyl-L-methionine"}
{"X":28228,"RHEA_ID":36118,"compounds":"gibberellin A3 + S-adenosyl-L-methionine <=> O-methyl gibberellin A3 + S-adenosyl-L-homocysteine"}
{"X":28229,"RHEA_ID":25556,"DIRECTION":"UN","MASTER_ID":25556,"ec":"4.2.3.34","compounds":"9alpha-copalyl diphosphate = diphosphate + stemod-13(17)-ene"}
{"X":28230,"RHEA_ID":25557,"DIRECTION":"LR","MASTER_ID":25556,"metacyc":"RXN-9291","compounds":"9alpha-copalyl diphosphate => diphosphate + stemod-13(17)-ene"}
{"X":28231,"RHEA_ID":36120,"DIRECTION":"LR","MASTER_ID":36119,"metacyc":"RXN-11358","compounds":"gibberellin A9 + S-adenosyl-L-methionine => O-methyl gibberellin A9 + S-adenosyl-L-homocysteine"}
{"X":28232,"RHEA_ID":36121,"compounds":"O-methyl gibberellin A9 + S-adenosyl-L-homocysteine => gibberellin A9 + S-adenosyl-L-methionine"}
{"X":28233,"RHEA_ID":25560,"DIRECTION":"UN","MASTER_ID":25560,"ec":"4.2.3.35","compounds":"9alpha-copalyl diphosphate = 9beta-pimara-7,15-diene + diphosphate"}
{"X":28234,"RHEA_ID":25561,"DIRECTION":"LR","MASTER_ID":25560,"metacyc":"RXN-4883","compounds":"9alpha-copalyl diphosphate => 9beta-pimara-7,15-diene + diphosphate"}
{"X":28235,"RHEA_ID":25562,"compounds":"9beta-pimara-7,15-diene + diphosphate => 9alpha-copalyl diphosphate"}
{"X":28236,"RHEA_ID":36125,"compounds":"gibberellin A20 methyl ester + S-adenosyl-L-homocysteine => gibberellin A20 + S-adenosyl-L-methionine"}
{"X":28237,"RHEA_ID":25564,"DIRECTION":"UN","MASTER_ID":25564,"ec":"3.1.1.53","compounds":"H2O + N-acetyl-4-O-acetylneuraminate = acetate + H(+) + N-acetylneuraminate"}
{"X":28238,"RHEA_ID":25565,"DIRECTION":"LR","MASTER_ID":25564,"metacyc":"RXN-13181","compounds":"H2O + N-acetyl-4-O-acetylneuraminate => acetate + H(+) + N-acetylneuraminate"}
{"X":28239,"RHEA_ID":25566,"compounds":"acetate + H(+) + N-acetylneuraminate => H2O + N-acetyl-4-O-acetylneuraminate"}
{"X":28240,"RHEA_ID":36128,"compounds":"gibberellin A34 + S-adenosyl-L-methionine => O-methyl gibberellin A34 + S-adenosyl-L-homocysteine"}
{"X":28241,"RHEA_ID":36129,"compounds":"O-methyl gibberellin A34 + S-adenosyl-L-homocysteine => gibberellin A34 + S-adenosyl-L-methionine"}
{"X":28242,"RHEA_ID":25569,"DIRECTION":"LR","MASTER_ID":25568,"metacyc":"RXN-8443","reactome":"R-HSA-8869607.3","compounds":"ATP + beta-D-ribosylnicotinate => ADP + H(+) + nicotinate beta-D-ribonucleotide"}
{"X":28243,"RHEA_ID":25569,"DIRECTION":"LR","MASTER_ID":25568,"metacyc":"RXN-8443","reactome":"R-HSA-8869606.3","compounds":"ATP + beta-D-ribosylnicotinate => ADP + H(+) + nicotinate beta-D-ribonucleotide"}
{"X":28244,"RHEA_ID":25570,"compounds":"ADP + H(+) + nicotinate beta-D-ribonucleotide => ATP + beta-D-ribosylnicotinate"}
{"X":28245,"RHEA_ID":36133,"compounds":"methyl (indol-3-yl)acetate + S-adenosyl-L-homocysteine => (indol-3-yl)acetate + S-adenosyl-L-methionine"}
{"X":28246,"RHEA_ID":25572,"compounds":"geranylgeranyl diphosphate + 2 H2O = diphosphate + sclareol"}
{"X":28247,"RHEA_ID":25573,"compounds":"geranylgeranyl diphosphate + 2 H2O => diphosphate + sclareol"}
{"X":28248,"RHEA_ID":25574,"compounds":"diphosphate + sclareol => geranylgeranyl diphosphate + 2 H2O"}
{"X":28249,"RHEA_ID":36137,"compounds":"(E)-hexadec-2-enoate + 2 H(+) + NADH => (2E)-hexadecenal + H2O + NAD(+)"}
{"X":28250,"RHEA_ID":25576,"DIRECTION":"UN","MASTER_ID":25576,"ec":"1.3.3.4","compounds":"3 O2 + protoporphyrinogen IX = 3 H2O2 + protoporphyrin IX"}
{"X":28251,"RHEA_ID":25577,"DIRECTION":"LR","MASTER_ID":25576,"ecocyc":"PROTOPORGENOXI-RXN","metacyc":"PROTOPORGENOXI-RXN","reactome":"R-HSA-189423.1","compounds":"3 O2 + protoporphyrinogen IX => 3 H2O2 + protoporphyrin IX"}
{"X":28252,"RHEA_ID":25578,"compounds":"3 H2O2 + protoporphyrin IX => 3 O2 + protoporphyrinogen IX"}
{"X":28253,"RHEA_ID":46061,"compounds":"(11E)-octadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => (5Z,11E)-octadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":28254,"RHEA_ID":25580,"DIRECTION":"UN","MASTER_ID":25580,"ec":"5.1.3.29","compounds":"alpha-L-fucose = beta-L-fucose"}
{"X":28255,"RHEA_ID":25581,"DIRECTION":"LR","MASTER_ID":25580,"reactome":"R-HSA-6787677.1","compounds":"alpha-L-fucose => beta-L-fucose"}
{"X":28256,"RHEA_ID":25582,"compounds":"beta-L-fucose => alpha-L-fucose"}
{"X":28257,"RHEA_ID":36145,"compounds":"hexadecanoyl-CoA + NADP(+) => (2E)-hexadecenoyl-CoA + H(+) + NADPH"}
{"X":28258,"RHEA_ID":25584,"DIRECTION":"UN","MASTER_ID":25584,"ec":"5.1.3.32","compounds":"alpha-L-rhamnose = beta-L-rhamnose"}
{"X":28259,"RHEA_ID":25585,"compounds":"alpha-L-rhamnose => beta-L-rhamnose"}
{"X":28260,"RHEA_ID":25586,"compounds":"beta-L-rhamnose => alpha-L-rhamnose"}
{"X":28261,"RHEA_ID":25587,"DIRECTION":"BI","MASTER_ID":25584,"ecocyc":"RXN0-5306","metacyc":"RXN0-5306","compounds":"alpha-L-rhamnose <=> beta-L-rhamnose"}
{"X":28262,"RHEA_ID":25588,"compounds":"isocitrate + NADP(+) = H(+) + NADPH + oxalosuccinate"}
{"X":28263,"RHEA_ID":25589,"compounds":"isocitrate + NADP(+) => H(+) + NADPH + oxalosuccinate"}
{"X":28264,"RHEA_ID":25590,"compounds":"H(+) + NADPH + oxalosuccinate => isocitrate + NADP(+)"}
{"X":28265,"RHEA_ID":46073,"compounds":"(2E)-hexadecenoyl-CoA + H(+) + NADH => hexadecanoyl-CoA + NAD(+)"}
{"X":28266,"RHEA_ID":25593,"DIRECTION":"UN","MASTER_ID":25593,"ec":"2.2.1.9","compounds":"2-oxoglutarate + H(+) + isochorismate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2"}
{"X":28267,"RHEA_ID":25594,"DIRECTION":"LR","MASTER_ID":25593,"ecocyc":"2.5.1.64-RXN","metacyc":"2.5.1.64-RXN","compounds":"2-oxoglutarate + H(+) + isochorismate => 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2"}
{"X":28268,"RHEA_ID":25595,"compounds":"5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2 => 2-oxoglutarate + H(+) + isochorismate"}
{"X":28269,"RHEA_ID":46077,"compounds":"(2E)-eicosenoyl-CoA + H(+) + NADH => eicosanoyl-CoA + NAD(+)"}
{"X":28270,"RHEA_ID":25597,"DIRECTION":"UN","MASTER_ID":25597,"ec":"4.2.99.20","compounds":"5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate = (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate + pyruvate"}
{"X":28271,"RHEA_ID":25598,"DIRECTION":"LR","MASTER_ID":25597,"ecocyc":"RXN-9310","metacyc":"RXN-9310","compounds":"5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate => (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate + pyruvate"}
{"X":28272,"RHEA_ID":25599,"compounds":"(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate + pyruvate => 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate"}
{"X":28273,"RHEA_ID":46081,"compounds":"(2E)-tetracosenoyl-CoA + H(+) + NADH => NAD(+) + tetracosanoyl-CoA"}
{"X":28274,"RHEA_ID":25601,"DIRECTION":"UN","MASTER_ID":25601,"ec":"2.3.3.17","compounds":"4-methylsulfanyl-2-oxobutanoate + acetyl-CoA + H2O = 2-(2-methylsulfanyl)ethylmalate + CoA + H(+)"}
{"X":28275,"RHEA_ID":25602,"DIRECTION":"LR","MASTER_ID":25601,"metacyc":"RXN-2202","compounds":"4-methylsulfanyl-2-oxobutanoate + acetyl-CoA + H2O => 2-(2-methylsulfanyl)ethylmalate + CoA + H(+)"}
{"X":28276,"RHEA_ID":25603,"compounds":"2-(2-methylsulfanyl)ethylmalate + CoA + H(+) => 4-methylsulfanyl-2-oxobutanoate + acetyl-CoA + H2O"}
{"X":28277,"RHEA_ID":46085,"DIRECTION":"LR","MASTER_ID":46084,"metacyc":"RXN-14964","compounds":"H2O + sn-glycerol 1-phosphate => glycerol + phosphate"}
{"X":28278,"RHEA_ID":25605,"DIRECTION":"UN","MASTER_ID":25605,"ec":"2.3.3.17","compounds":"2-(5-methylsulfanyl)oxopentanoate + acetyl-CoA + H2O = 2-(3-methylsulfanyl)propylmalate + CoA + H(+)"}
{"X":28279,"RHEA_ID":25606,"DIRECTION":"LR","MASTER_ID":25605,"metacyc":"RXNQT-4163","compounds":"2-(5-methylsulfanyl)oxopentanoate + acetyl-CoA + H2O => 2-(3-methylsulfanyl)propylmalate + CoA + H(+)"}
{"X":28280,"RHEA_ID":25607,"compounds":"2-(3-methylsulfanyl)propylmalate + CoA + H(+) => 2-(5-methylsulfanyl)oxopentanoate + acetyl-CoA + H2O"}
{"X":28281,"RHEA_ID":25608,"compounds":"2-(5-methylsulfanyl)oxopentanoate + acetyl-CoA + H2O <=> 2-(3-methylsulfanyl)propylmalate + CoA + H(+)"}
{"X":28282,"RHEA_ID":25609,"DIRECTION":"UN","MASTER_ID":25609,"ec":"5.4.99.62","compounds":"beta-D-allofuranose = beta-D-allopyranose"}
{"X":28283,"RHEA_ID":25610,"compounds":"beta-D-allofuranose => beta-D-allopyranose"}
{"X":28284,"RHEA_ID":25611,"compounds":"beta-D-allopyranose => beta-D-allofuranose"}
{"X":28285,"RHEA_ID":25612,"compounds":"beta-D-allofuranose <=> beta-D-allopyranose"}
{"X":28286,"RHEA_ID":25613,"DIRECTION":"UN","MASTER_ID":25613,"ec":"5.5.1.15","compounds":"all-trans-geranylgeranyl diphosphate = terpentedienyl diphosphate"}
{"X":28287,"RHEA_ID":25614,"DIRECTION":"LR","MASTER_ID":25613,"metacyc":"RXN-9456","compounds":"all-trans-geranylgeranyl diphosphate => terpentedienyl diphosphate"}
{"X":28288,"RHEA_ID":25615,"compounds":"terpentedienyl diphosphate => all-trans-geranylgeranyl diphosphate"}
{"X":28289,"RHEA_ID":46101,"compounds":"11-deoxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => cortisol + H2O + 2 oxidized [adrenodoxin]"}
{"X":28290,"RHEA_ID":25617,"DIRECTION":"UN","MASTER_ID":25617,"ec":"4.2.3.36","compounds":"terpentedienyl diphosphate = diphosphate + terpentetriene"}
{"X":28291,"RHEA_ID":25618,"DIRECTION":"LR","MASTER_ID":25617,"metacyc":"RXN-9455","compounds":"terpentedienyl diphosphate => diphosphate + terpentetriene"}
{"X":28292,"RHEA_ID":25619,"compounds":"diphosphate + terpentetriene => terpentedienyl diphosphate"}
{"X":28293,"RHEA_ID":46105,"compounds":"21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] => corticosterone + H2O + 2 oxidized [adrenodoxin]"}
{"X":28294,"RHEA_ID":25621,"DIRECTION":"UN","MASTER_ID":25621,"ec":"5.5.1.16","compounds":"geranylgeranyl diphosphate = tuberculosinyl diphosphate"}
{"X":28295,"RHEA_ID":25622,"DIRECTION":"LR","MASTER_ID":25621,"metacyc":"RXN-9457","compounds":"geranylgeranyl diphosphate => tuberculosinyl diphosphate"}
{"X":28296,"RHEA_ID":25623,"compounds":"tuberculosinyl diphosphate => geranylgeranyl diphosphate"}
{"X":28297,"RHEA_ID":46109,"compounds":"(2E,6E,10E)-geranylgeraniol + H(+) + 2 NADPH + 2 O2 => (2E,6E,10E)-geranylgeranate + 3 H2O + 2 NADP(+)"}
{"X":28298,"RHEA_ID":25625,"DIRECTION":"UN","MASTER_ID":25625,"ec":"1.4.3.22","compounds":"H2O + histamine + O2 = H2O2 + imidazole-4-acetaldehyde + NH4(+)"}
{"X":28299,"RHEA_ID":25626,"DIRECTION":"LR","MASTER_ID":25625,"metacyc":"RXN-9600","reactome":"R-HSA-5696131.1","compounds":"H2O + histamine + O2 => H2O2 + imidazole-4-acetaldehyde + NH4(+)"}
{"X":28300,"RHEA_ID":25627,"compounds":"H2O2 + imidazole-4-acetaldehyde + NH4(+) => H2O + histamine + O2"}
{"X":28301,"RHEA_ID":46113,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine"}
{"X":28302,"RHEA_ID":25629,"DIRECTION":"UN","MASTER_ID":25629,"ec":"2.1.1.267","compounds":"myricetin + S-adenosyl-L-methionine = H(+) + laricitrin + S-adenosyl-L-homocysteine"}
{"X":28303,"RHEA_ID":25630,"DIRECTION":"LR","MASTER_ID":25629,"metacyc":"RXN-8451","compounds":"myricetin + S-adenosyl-L-methionine => H(+) + laricitrin + S-adenosyl-L-homocysteine"}
{"X":28304,"RHEA_ID":25631,"compounds":"H(+) + laricitrin + S-adenosyl-L-homocysteine => myricetin + S-adenosyl-L-methionine"}
{"X":28305,"RHEA_ID":46117,"compounds":"2-dehydro-3-deoxy-D-galactonate => D-glyceraldehyde + pyruvate"}
{"X":28306,"RHEA_ID":25633,"DIRECTION":"UN","MASTER_ID":25633,"ec":"2.1.1.267","compounds":"laricitrin + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + syringetin"}
{"X":28307,"RHEA_ID":25634,"DIRECTION":"LR","MASTER_ID":25633,"metacyc":"RXN-8452","compounds":"laricitrin + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + syringetin"}
{"X":28308,"RHEA_ID":25635,"compounds":"H(+) + S-adenosyl-L-homocysteine + syringetin => laricitrin + S-adenosyl-L-methionine"}
{"X":28309,"RHEA_ID":46121,"compounds":"4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 4beta,7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":28310,"RHEA_ID":25637,"DIRECTION":"UN","MASTER_ID":25637,"ec":"1.2.1.73","compounds":"H2O + NAD(+) + sulfoacetaldehyde = 2 H(+) + NADH + sulfoacetate"}
{"X":28311,"RHEA_ID":25638,"compounds":"H2O + NAD(+) + sulfoacetaldehyde => 2 H(+) + NADH + sulfoacetate"}
{"X":28312,"RHEA_ID":25639,"compounds":"2 H(+) + NADH + sulfoacetate => H2O + NAD(+) + sulfoacetaldehyde"}
{"X":28313,"RHEA_ID":36201,"compounds":"1-O-(1Z-alkenyl)-sn-glycerol + H(+) + phosphoethanolamine => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O"}
{"X":28314,"RHEA_ID":25641,"DIRECTION":"UN","MASTER_ID":25641,"ec":"1.3.1.81","compounds":"(1R,4S)-menthone + NADP(+) = (R)-pulegone + H(+) + NADPH"}
{"X":28315,"RHEA_ID":25642,"compounds":"(1R,4S)-menthone + NADP(+) => (R)-pulegone + H(+) + NADPH"}
{"X":28316,"RHEA_ID":25643,"DIRECTION":"RL","MASTER_ID":25641,"metacyc":"RXN-5163","compounds":"(R)-pulegone + H(+) + NADPH => (1R,4S)-menthone + NADP(+)"}
{"X":28317,"RHEA_ID":46129,"compounds":"cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 4beta-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":28318,"RHEA_ID":25645,"DIRECTION":"UN","MASTER_ID":25645,"ec":"1.3.1.81","compounds":"(2R,5R)-isomenthone + NADP(+) = (R)-pulegone + H(+) + NADPH"}
{"X":28319,"RHEA_ID":25646,"compounds":"(2R,5R)-isomenthone + NADP(+) => (R)-pulegone + H(+) + NADPH"}
{"X":28320,"RHEA_ID":25647,"DIRECTION":"RL","MASTER_ID":25645,"metacyc":"RXN-5164","compounds":"(R)-pulegone + H(+) + NADPH => (2R,5R)-isomenthone + NADP(+)"}
{"X":28321,"RHEA_ID":46133,"DIRECTION":"LR","MASTER_ID":46132,"reactome":"R-HSA-191983.1","compounds":"cholesterol + H(+) + NADPH + O2 => 25-hydroxycholesterol + H2O + NADP(+)"}
{"X":28322,"RHEA_ID":25649,"DIRECTION":"UN","MASTER_ID":25649,"ec":"1.3.1.82","compounds":"(2R,5R)-isopulegone + NADP(+) = (6R)-isopiperitenone + H(+) + NADPH"}
{"X":28323,"RHEA_ID":25650,"compounds":"(2R,5R)-isopulegone + NADP(+) => (6R)-isopiperitenone + H(+) + NADPH"}
{"X":28324,"RHEA_ID":25651,"DIRECTION":"RL","MASTER_ID":25649,"metacyc":"RXN-5161","compounds":"(6R)-isopiperitenone + H(+) + NADPH => (2R,5R)-isopulegone + NADP(+)"}
{"X":28325,"RHEA_ID":36213,"compounds":"1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + phosphate => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + H2O"}
{"X":28326,"RHEA_ID":25653,"compounds":"(2S)-2-amino-3-oxobutanoate + H(+) = aminoacetone + CO2"}
{"X":28327,"RHEA_ID":25654,"DIRECTION":"LR","MASTER_ID":25653,"ecocyc":"THREOSPON-RXN","metacyc":"THREOSPON-RXN","compounds":"(2S)-2-amino-3-oxobutanoate + H(+) => aminoacetone + CO2"}
{"X":28328,"RHEA_ID":25655,"compounds":"aminoacetone + CO2 => (2S)-2-amino-3-oxobutanoate + H(+)"}
{"X":28329,"RHEA_ID":36217,"compounds":"1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+) => 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-ethanolamine"}
{"X":28330,"RHEA_ID":25658,"DIRECTION":"UN","MASTER_ID":25658,"ec":"1.14.14.143","compounds":"(R)-pulegone + O2 + reduced [NADPH--hemoprotein reductase] = (R)-menthofuran + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":28331,"RHEA_ID":25659,"DIRECTION":"LR","MASTER_ID":25658,"metacyc":"1.14.13.104-RXN","compounds":"(R)-pulegone + O2 + reduced [NADPH--hemoprotein reductase] => (R)-menthofuran + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":28332,"RHEA_ID":25660,"compounds":"(R)-menthofuran + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (R)-pulegone + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":28333,"RHEA_ID":36221,"compounds":"1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + ethanolamine + H(+) => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O"}
{"X":28334,"RHEA_ID":25662,"compounds":"(2E)-geranyl diphosphate = alpha-pinene + diphosphate"}
{"X":28335,"RHEA_ID":25663,"DIRECTION":"LR","MASTER_ID":25662,"metacyc":"RXN-5106","compounds":"(2E)-geranyl diphosphate => alpha-pinene + diphosphate"}
{"X":28336,"RHEA_ID":25664,"compounds":"alpha-pinene + diphosphate => (2E)-geranyl diphosphate"}
{"X":28337,"RHEA_ID":46149,"DIRECTION":"LR","MASTER_ID":46148,"reactome":"R-HSA-8866601.3","compounds":"a 2'-deoxyribonucleoside 5'-triphosphate + H2O => a 2'-deoxyribonucleoside + H(+) + triphosphate"}
{"X":28338,"RHEA_ID":25666,"compounds":"(2E)-geranyl diphosphate = beta-pinene + diphosphate"}
{"X":28339,"RHEA_ID":25667,"DIRECTION":"LR","MASTER_ID":25666,"metacyc":"RXN-5107","compounds":"(2E)-geranyl diphosphate => beta-pinene + diphosphate"}
{"X":28340,"RHEA_ID":25668,"compounds":"beta-pinene + diphosphate => (2E)-geranyl diphosphate"}
{"X":28341,"RHEA_ID":46153,"DIRECTION":"LR","MASTER_ID":46152,"metacyc":"RXN-12243","compounds":"15-cis-phytoene + a plastoquinone => 15,9'-di-cis-phytofluene + a plastoquinol"}
{"X":28342,"RHEA_ID":25670,"DIRECTION":"UN","MASTER_ID":25670,"ec":"2.4.1.n2","metacyc":"RXN-9934","compounds":"sucrose + UDP-alpha-D-galactose = H(+) + loliose + UDP"}
{"X":28343,"RHEA_ID":25671,"compounds":"sucrose + UDP-alpha-D-galactose => H(+) + loliose + UDP"}
{"X":28344,"RHEA_ID":25672,"compounds":"H(+) + loliose + UDP => sucrose + UDP-alpha-D-galactose"}
{"X":28345,"RHEA_ID":36233,"compounds":"1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+) => 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O"}
{"X":28346,"RHEA_ID":25674,"DIRECTION":"UN","MASTER_ID":25674,"ec":"3.1.3.78","compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate"}
{"X":28347,"RHEA_ID":25675,"DIRECTION":"LR","MASTER_ID":25674,"metacyc":"RXN-9779","compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate"}
{"X":28348,"RHEA_ID":25676,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O"}
{"X":28349,"RHEA_ID":36237,"compounds":"1-O-alkyl-2-acyl-sn-glycero-3-phosphate + CoA => 1-O-alkyl-sn-glycero-3-phosphate + an acyl-CoA"}
{"X":28350,"RHEA_ID":25678,"DIRECTION":"UN","MASTER_ID":25678,"ec":"6.1.1.27","compounds":"ATP + O-phospho-L-serine + tRNA(Cys) = AMP + diphosphate + O-phospho-L-seryl-tRNA(Cys)"}
{"X":28351,"RHEA_ID":25679,"DIRECTION":"LR","MASTER_ID":25678,"metacyc":"RXN-10718","compounds":"ATP + O-phospho-L-serine + tRNA(Cys) => AMP + diphosphate + O-phospho-L-seryl-tRNA(Cys)"}
{"X":28352,"RHEA_ID":25680,"compounds":"AMP + diphosphate + O-phospho-L-seryl-tRNA(Cys) => ATP + O-phospho-L-serine + tRNA(Cys)"}
{"X":28353,"RHEA_ID":46164,"DIRECTION":"UN","MASTER_ID":46164,"ec":"1.6.5.2","compounds":"a quinone + H(+) + NADPH = a quinol + NADP(+)"}
{"X":28354,"RHEA_ID":25682,"compounds":"L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase]"}
{"X":28355,"RHEA_ID":25683,"DIRECTION":"LR","MASTER_ID":25682,"metacyc":"RXN-13017","compounds":"L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase]"}
{"X":28356,"RHEA_ID":25684,"compounds":"2 H(+) + H2O + N-hydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase] => L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":28357,"RHEA_ID":36245,"DIRECTION":"RL","MASTER_ID":36243,"metacyc":"RXN-11264","compounds":"NADPH + trans-coumaryl acetate => acetate + NADP(+) + trans-anol"}
{"X":28358,"RHEA_ID":25686,"DIRECTION":"UN","MASTER_ID":25686,"ec":"2.5.1.73","compounds":"H(+) + hydrogen sulfide + O-phospho-L-seryl-tRNA(Cys) = L-cysteinyl-tRNA(Cys) + phosphate"}
{"X":28359,"RHEA_ID":25687,"DIRECTION":"LR","MASTER_ID":25686,"metacyc":"RXN-10719","compounds":"H(+) + hydrogen sulfide + O-phospho-L-seryl-tRNA(Cys) => L-cysteinyl-tRNA(Cys) + phosphate"}
{"X":28360,"RHEA_ID":25688,"compounds":"L-cysteinyl-tRNA(Cys) + phosphate => H(+) + hydrogen sulfide + O-phospho-L-seryl-tRNA(Cys)"}
{"X":28361,"RHEA_ID":36249,"compounds":"H(+) + S-adenosyl-L-homocysteine + trans-anethole => S-adenosyl-L-methionine + trans-anol"}
{"X":28362,"RHEA_ID":25690,"DIRECTION":"UN","MASTER_ID":25690,"ec":"2.7.7.67","compounds":"2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate + CTP + H(+) = CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol + diphosphate"}
{"X":28363,"RHEA_ID":25691,"DIRECTION":"LR","MASTER_ID":25690,"metacyc":"RXN-9995","compounds":"2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate + CTP + H(+) => CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol + diphosphate"}
{"X":28364,"RHEA_ID":25692,"compounds":"CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol + diphosphate => 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate + CTP + H(+)"}
{"X":28365,"RHEA_ID":36253,"compounds":"(E)-feruloyl-CoA + AMP + diphosphate => ATP + CoA + trans-ferulate"}
{"X":28366,"RHEA_ID":25694,"DIRECTION":"UN","MASTER_ID":25694,"ec":"2.5.1.81","compounds":"all-trans-geranylgeranyl diphosphate + isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate"}
{"X":28367,"RHEA_ID":25695,"compounds":"all-trans-geranylgeranyl diphosphate + isopentenyl diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate"}
{"X":28368,"RHEA_ID":25696,"compounds":"(2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate => all-trans-geranylgeranyl diphosphate + isopentenyl diphosphate"}
{"X":28369,"RHEA_ID":46178,"compounds":"2-methylpropanoyl-CoA + AMP + diphosphate => 2-methylpropanoate + ATP + CoA"}
{"X":28370,"RHEA_ID":25698,"compounds":"H(+) + N,N-dihydroxy-L-hexahomomethionine = (E)-9-(methylsulfanyl)nonanal oxime + CO2 + H2O"}
{"X":28371,"RHEA_ID":25699,"DIRECTION":"LR","MASTER_ID":25698,"metacyc":"RXN-12991","compounds":"H(+) + N,N-dihydroxy-L-hexahomomethionine => (E)-9-(methylsulfanyl)nonanal oxime + CO2 + H2O"}
{"X":28372,"RHEA_ID":25700,"compounds":"(E)-9-(methylsulfanyl)nonanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-hexahomomethionine"}
{"X":28373,"RHEA_ID":36261,"compounds":"an aldehyde + glycerol => a 1-(1-hydroxyalkyl)-sn-glycerol"}
{"X":28374,"RHEA_ID":25702,"compounds":"N-hydroxy-L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase]"}
{"X":28375,"RHEA_ID":25703,"DIRECTION":"LR","MASTER_ID":25702,"metacyc":"RXN-13019","compounds":"N-hydroxy-L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase]"}
{"X":28376,"RHEA_ID":25704,"compounds":"H(+) + H2O + N,N-dihydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":28377,"RHEA_ID":36265,"compounds":"acetate + H(+) + O-ureido-L-serine => hydroxyurea + O-acetyl-L-serine"}
{"X":28378,"RHEA_ID":25706,"compounds":"H(+) + N,N-dihydroxy-L-dihomomethionine = (E)-5-(methylsulfanyl)pentanal oxime + CO2 + H2O"}
{"X":28379,"RHEA_ID":25707,"DIRECTION":"LR","MASTER_ID":25706,"metacyc":"RXN-13020","compounds":"H(+) + N,N-dihydroxy-L-dihomomethionine => (E)-5-(methylsulfanyl)pentanal oxime + CO2 + H2O"}
{"X":28380,"RHEA_ID":25708,"compounds":"(E)-5-(methylsulfanyl)pentanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-dihomomethionine"}
{"X":28381,"RHEA_ID":36269,"compounds":"formaldehyde + H2O + NAD(+) + theobromine => caffeine + H(+) + NADH + O2"}
{"X":28382,"RHEA_ID":25711,"compounds":"L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase]"}
{"X":28383,"RHEA_ID":25712,"DIRECTION":"LR","MASTER_ID":25711,"metacyc":"RXN-13021","compounds":"L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase]"}
{"X":28384,"RHEA_ID":25713,"compounds":"2 H(+) + H2O + N-hydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase] => L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":28385,"RHEA_ID":36273,"compounds":"formaldehyde + H2O + NADP(+) + theobromine => caffeine + H(+) + NADPH + O2"}
{"X":28386,"RHEA_ID":25715,"compounds":"N-hydroxy-L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase]"}
{"X":28387,"RHEA_ID":25716,"DIRECTION":"LR","MASTER_ID":25715,"metacyc":"RXN-13022","compounds":"N-hydroxy-L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase]"}
{"X":28388,"RHEA_ID":25717,"compounds":"H(+) + H2O + N,N-dihydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":28389,"RHEA_ID":36277,"compounds":"3-methylxanthine + formaldehyde + H2O + NADP(+) => H(+) + NADPH + O2 + theophylline"}
{"X":28390,"RHEA_ID":25719,"compounds":"H(+) + N,N-dihydroxy-L-trihomomethionine = (E)-6-(methylsulfanyl)hexanal oxime + CO2 + H2O"}
{"X":28391,"RHEA_ID":25720,"DIRECTION":"LR","MASTER_ID":25719,"metacyc":"RXN-13023","compounds":"H(+) + N,N-dihydroxy-L-trihomomethionine => (E)-6-(methylsulfanyl)hexanal oxime + CO2 + H2O"}
{"X":28392,"RHEA_ID":25721,"compounds":"(E)-6-(methylsulfanyl)hexanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-trihomomethionine"}
{"X":28393,"RHEA_ID":25722,"compounds":"H(+) + N,N-dihydroxy-L-trihomomethionine <=> (E)-6-(methylsulfanyl)hexanal oxime + CO2 + H2O"}
{"X":28394,"RHEA_ID":25723,"compounds":"L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase]"}
{"X":28395,"RHEA_ID":25724,"DIRECTION":"LR","MASTER_ID":25723,"metacyc":"RXN-12989","compounds":"L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase]"}
{"X":28396,"RHEA_ID":25725,"compounds":"2 H(+) + H2O + N-hydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase] => L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":28397,"RHEA_ID":36285,"compounds":"7-methylxanthine + formaldehyde + H2O + NADP(+) => 1,7-dimethylxanthine + H(+) + NADPH + O2"}
{"X":28398,"RHEA_ID":25727,"compounds":"N-hydroxy-L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase]"}
{"X":28399,"RHEA_ID":25728,"DIRECTION":"LR","MASTER_ID":25727,"metacyc":"RXN-13024","compounds":"N-hydroxy-L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase]"}
{"X":28400,"RHEA_ID":25729,"compounds":"H(+) + H2O + N,N-dihydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":28401,"RHEA_ID":36289,"compounds":"7-methylxanthine + formaldehyde + H2O + NADP(+) => H(+) + NADPH + O2 + theobromine"}
{"X":28402,"RHEA_ID":25731,"compounds":"H(+) + N,N-dihydroxy-L-tetrahomomethionine = (E)-7-(methylsulfanyl)heptanal oxime + CO2 + H2O"}
{"X":28403,"RHEA_ID":25732,"DIRECTION":"LR","MASTER_ID":25731,"metacyc":"RXN-13025","compounds":"H(+) + N,N-dihydroxy-L-tetrahomomethionine => (E)-7-(methylsulfanyl)heptanal oxime + CO2 + H2O"}
{"X":28404,"RHEA_ID":25733,"compounds":"(E)-7-(methylsulfanyl)heptanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-tetrahomomethionine"}
{"X":28405,"RHEA_ID":36293,"compounds":"formaldehyde + H2O + NADP(+) + xanthine => 3-methylxanthine + H(+) + NADPH + O2"}
{"X":28406,"RHEA_ID":25735,"compounds":"L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase]"}
{"X":28407,"RHEA_ID":25736,"DIRECTION":"LR","MASTER_ID":25735,"metacyc":"RXN-13003","compounds":"L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase]"}
{"X":28408,"RHEA_ID":25737,"compounds":"2 H(+) + H2O + N-hydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase] => L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":28409,"RHEA_ID":36297,"compounds":"D-maltose + phosphate => alpha-maltose 6'-phosphate + H2O"}
{"X":28410,"RHEA_ID":25739,"compounds":"N-hydroxy-L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase]"}
{"X":28411,"RHEA_ID":25740,"DIRECTION":"LR","MASTER_ID":25739,"metacyc":"RXN-13004","compounds":"N-hydroxy-L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase]"}
{"X":28412,"RHEA_ID":25741,"compounds":"H(+) + H2O + N,N-dihydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":28413,"RHEA_ID":25742,"compounds":"N-hydroxy-L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase]"}
{"X":28414,"RHEA_ID":25743,"compounds":"H(+) + N,N-dihydroxy-L-pentahomomethionine = (E)-8-(methylsulfanyl)octanal oxime + CO2 + H2O"}
{"X":28415,"RHEA_ID":25744,"DIRECTION":"LR","MASTER_ID":25743,"metacyc":"RXN-13005","compounds":"H(+) + N,N-dihydroxy-L-pentahomomethionine => (E)-8-(methylsulfanyl)octanal oxime + CO2 + H2O"}
{"X":28416,"RHEA_ID":25745,"compounds":"(E)-8-(methylsulfanyl)octanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-pentahomomethionine"}
{"X":28417,"RHEA_ID":25746,"compounds":"H(+) + N,N-dihydroxy-L-pentahomomethionine <=> (E)-8-(methylsulfanyl)octanal oxime + CO2 + H2O"}
{"X":28418,"RHEA_ID":25747,"compounds":"L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase]"}
{"X":28419,"RHEA_ID":25748,"DIRECTION":"LR","MASTER_ID":25747,"metacyc":"RXN-13027","compounds":"L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase]"}
{"X":28420,"RHEA_ID":25749,"compounds":"2 H(+) + H2O + N-hydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase] => L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":28421,"RHEA_ID":36309,"compounds":"3,4-dihydroxybenzaldehyde + acetyl-CoA => (E)-caffeoyl-CoA + H2O"}
{"X":28422,"RHEA_ID":25751,"compounds":"N-hydroxy-L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase]"}
{"X":28423,"RHEA_ID":25752,"DIRECTION":"LR","MASTER_ID":25751,"metacyc":"RXN-12990","compounds":"N-hydroxy-L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase]"}
{"X":28424,"RHEA_ID":25753,"compounds":"H(+) + H2O + N,N-dihydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":28425,"RHEA_ID":36313,"compounds":"3,4-dihydroxybenzoate + 2 H(+) + NADH => 3,4-dihydroxybenzaldehyde + H2O + NAD(+)"}
{"X":28426,"RHEA_ID":25759,"DIRECTION":"UN","MASTER_ID":25759,"ec":"4.2.3.103","compounds":"ent-copalyl diphosphate = diphosphate + ent-isokaurene"}
{"X":28427,"RHEA_ID":25760,"DIRECTION":"LR","MASTER_ID":25759,"metacyc":"RXN-12593","compounds":"ent-copalyl diphosphate => diphosphate + ent-isokaurene"}
{"X":28428,"RHEA_ID":25761,"compounds":"diphosphate + ent-isokaurene => ent-copalyl diphosphate"}
{"X":28429,"RHEA_ID":46238,"compounds":"2 [Fe(III)-cytochrome b5] + a (5Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 H2O => 2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2"}
{"X":28430,"RHEA_ID":25763,"DIRECTION":"UN","MASTER_ID":25763,"ec":"1.1.1.n5","compounds":"(2R,3S)-3-methylmalate + NAD(+) = 3-carboxy-2-oxobutanoate + H(+) + NADH"}
{"X":28431,"RHEA_ID":25764,"compounds":"(2R,3S)-3-methylmalate + NAD(+) => 3-carboxy-2-oxobutanoate + H(+) + NADH"}
{"X":28432,"RHEA_ID":25765,"compounds":"3-carboxy-2-oxobutanoate + H(+) + NADH => (2R,3S)-3-methylmalate + NAD(+)"}
{"X":28433,"RHEA_ID":25766,"compounds":"(2R,3S)-3-methylmalate + NAD(+) <=> 3-carboxy-2-oxobutanoate + H(+) + NADH"}
{"X":28434,"RHEA_ID":36321,"compounds":"CoA + 2 NADP(+) + octadecan-1-ol => 2 H(+) + 2 NADPH + octadecanoyl-CoA"}
{"X":28435,"RHEA_ID":25768,"compounds":"3-carboxy-2-oxobutanoate + H(+) => 2-oxobutanoate + CO2"}
{"X":28436,"RHEA_ID":25769,"compounds":"2-oxobutanoate + CO2 => 3-carboxy-2-oxobutanoate + H(+)"}
{"X":28437,"RHEA_ID":25770,"compounds":"3-carboxy-2-oxobutanoate + H(+) <=> 2-oxobutanoate + CO2"}
{"X":28438,"RHEA_ID":36325,"compounds":"(9Z)-octadecen-1-ol + CoA + 2 NADP(+) => (9Z)-octadecenoyl-CoA + 2 H(+) + 2 NADPH"}
{"X":28439,"RHEA_ID":25773,"DIRECTION":"LR","MASTER_ID":25772,"metacyc":"RXN-14123","compounds":"2-oxoglutarate + L-asparagine + O2 => (2S,3S)-3-hydroxyasparagine + CO2 + succinate"}
{"X":28440,"RHEA_ID":25774,"compounds":"(2S,3S)-3-hydroxyasparagine + CO2 + succinate => 2-oxoglutarate + L-asparagine + O2"}
{"X":28441,"RHEA_ID":36328,"DIRECTION":"LR","MASTER_ID":36327,"metacyc":"RXN-4305","compounds":"ADP + dimethylallyl diphosphate => diphosphate + N(6)-(dimethylallyl)adenosine 5'-diphosphate"}
{"X":28442,"RHEA_ID":36329,"compounds":"diphosphate + N(6)-(dimethylallyl)adenosine 5'-diphosphate => ADP + dimethylallyl diphosphate"}
{"X":28443,"RHEA_ID":25777,"compounds":"scyllo-inosose => scyllo-inosine"}
{"X":28444,"RHEA_ID":25778,"compounds":"scyllo-inosine => scyllo-inosose"}
{"X":28445,"RHEA_ID":36332,"DIRECTION":"LR","MASTER_ID":36331,"metacyc":"RXN-4303","compounds":"ATP + dimethylallyl diphosphate => diphosphate + N(6)-(dimethylallyl)adenosine 5'-triphosphate"}
{"X":28446,"RHEA_ID":25780,"DIRECTION":"UN","MASTER_ID":25780,"ec":"1.1.1.336","compounds":"H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-mannosamine = 3 H(+) + 2 NADH + UDP-N-acetyl-alpha-D-mannosaminouronate"}
{"X":28447,"RHEA_ID":29709,"DIRECTION":"RL","MASTER_ID":29707,"ecocyc":"TRANS-RXN0-225","compounds":"1,6-anhydro-N-acetyl-beta-muramate(out) => 1,6-anhydro-N-acetyl-beta-muramate(in)"}
{"X":28448,"RHEA_ID":25782,"compounds":"3 H(+) + 2 NADH + UDP-N-acetyl-alpha-D-mannosaminouronate => H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-mannosamine"}
{"X":28449,"RHEA_ID":36336,"DIRECTION":"LR","MASTER_ID":36335,"metacyc":"RXN-11407","compounds":"D-glucuronate + H2O + NAD(+) => D-glucarate + 2 H(+) + NADH"}
{"X":28450,"RHEA_ID":36337,"compounds":"D-glucarate + 2 H(+) + NADH => D-glucuronate + H2O + NAD(+)"}
{"X":28451,"RHEA_ID":25785,"compounds":"2-dehydro-3-deoxy-L-rhamnonate => (S)-lactaldehyde + pyruvate"}
{"X":28452,"RHEA_ID":25786,"compounds":"(S)-lactaldehyde + pyruvate => 2-dehydro-3-deoxy-L-rhamnonate"}
{"X":28453,"RHEA_ID":36341,"compounds":"2-sulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine => [sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine"}
{"X":28454,"RHEA_ID":25789,"DIRECTION":"LR","MASTER_ID":25788,"metacyc":"4-HYDROXY-2-KETOPIMELATE-LYSIS-RXN","compounds":"4-hydroxy-2-oxoheptanedioate => pyruvate + succinate semialdehyde"}
{"X":28455,"RHEA_ID":25790,"compounds":"pyruvate + succinate semialdehyde => 4-hydroxy-2-oxoheptanedioate"}
{"X":28456,"RHEA_ID":36344,"compounds":"2-methylsulfanyl-N(6)-(Delta(2)-isopentenyl)adenosine in tRNA + H(+) + NADPH + O2 => 2-methylsulfanyl-N(6)-(cis-4-hydroxy-Delta(2)-isopentenyl)adenosine in tRNA + H2O + NADP(+)"}
{"X":28457,"RHEA_ID":36345,"compounds":"2-methylsulfanyl-N(6)-(cis-4-hydroxy-Delta(2)-isopentenyl)adenosine in tRNA + H2O + NADP(+) => 2-methylsulfanyl-N(6)-(Delta(2)-isopentenyl)adenosine in tRNA + H(+) + NADPH + O2"}
{"X":28458,"RHEA_ID":25793,"DIRECTION":"LR","MASTER_ID":25792,"ecocyc":"TRANS-RXN0-207","metacyc":"TRANS-RXN0-207","compounds":"ATP + Cu(+)(in) + H2O => ADP + Cu(+)(out) + H(+) + phosphate"}
{"X":28459,"RHEA_ID":25794,"compounds":"ADP + Cu(+)(out) + H(+) + phosphate => ATP + Cu(+)(in) + H2O"}
{"X":28460,"RHEA_ID":25795,"compounds":"ATP + Cu(+)(in) + H2O <=> ADP + Cu(+)(out) + H(+) + phosphate"}
{"X":28461,"RHEA_ID":36349,"compounds":"4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + CO2 + H2O + L-methionine => N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine"}
{"X":28462,"RHEA_ID":25797,"compounds":"2-oxoglutarate + L-methionine => 4-methylsulfanyl-2-oxobutanoate + L-glutamate"}
{"X":28463,"RHEA_ID":25798,"compounds":"4-methylsulfanyl-2-oxobutanoate + L-glutamate => 2-oxoglutarate + L-methionine"}
{"X":28464,"RHEA_ID":36352,"compounds":"AH2 + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-methionine => 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + A + H(+) + L-methionine"}
{"X":28465,"RHEA_ID":25800,"DIRECTION":"UN","MASTER_ID":25800,"ec":"1.5.3.13","compounds":"H2O + N(1)-acetylspermine + O2 = 3-acetamidopropanal + H2O2 + spermidine"}
{"X":28466,"RHEA_ID":25800,"DIRECTION":"UN","MASTER_ID":25800,"ec":"1.5.3.17","compounds":"H2O + N(1)-acetylspermine + O2 = 3-acetamidopropanal + H2O2 + spermidine"}
{"X":28467,"RHEA_ID":25801,"DIRECTION":"LR","MASTER_ID":25800,"metacyc":"RXN-12090","reactome":"R-HSA-141351.1","compounds":"H2O + N(1)-acetylspermine + O2 => 3-acetamidopropanal + H2O2 + spermidine"}
{"X":28468,"RHEA_ID":25802,"compounds":"3-acetamidopropanal + H2O2 + spermidine => H2O + N(1)-acetylspermine + O2"}
{"X":28469,"RHEA_ID":25804,"DIRECTION":"UN","MASTER_ID":25804,"ec":"1.5.3.17","compounds":"H2O + O2 + spermine = 3-aminopropanal + H2O2 + spermidine"}
{"X":28470,"RHEA_ID":25804,"DIRECTION":"UN","MASTER_ID":25804,"ec":"1.5.3.16","compounds":"H2O + O2 + spermine = 3-aminopropanal + H2O2 + spermidine"}
{"X":28471,"RHEA_ID":25804,"DIRECTION":"UN","MASTER_ID":25804,"ec":"1.5.3.13","compounds":"H2O + O2 + spermine = 3-aminopropanal + H2O2 + spermidine"}
{"X":28472,"RHEA_ID":25805,"DIRECTION":"LR","MASTER_ID":25804,"metacyc":"RXN-9015","reactome":"R-HSA-141341.1","compounds":"H2O + O2 + spermine => 3-aminopropanal + H2O2 + spermidine"}
{"X":28473,"RHEA_ID":25805,"DIRECTION":"LR","MASTER_ID":25804,"metacyc":"1.5.3.17-RXN","reactome":"R-HSA-141341.1","compounds":"H2O + O2 + spermine => 3-aminopropanal + H2O2 + spermidine"}
{"X":28474,"RHEA_ID":25806,"compounds":"3-aminopropanal + H2O2 + spermidine => H2O + O2 + spermine"}
{"X":28475,"RHEA_ID":36364,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 2 H(+) + 2 NADPH => (9Z,12Z)-octadecadien-1-ol + CoA + 2 NADP(+)"}
{"X":28476,"RHEA_ID":25808,"DIRECTION":"UN","MASTER_ID":25808,"ec":"1.5.3.17","compounds":"H2O + O2 + spermidine = 3-aminopropanal + H2O2 + putrescine"}
{"X":28477,"RHEA_ID":25808,"DIRECTION":"UN","MASTER_ID":25808,"ec":"1.5.3.13","compounds":"H2O + O2 + spermidine = 3-aminopropanal + H2O2 + putrescine"}
{"X":28478,"RHEA_ID":25809,"DIRECTION":"LR","MASTER_ID":25808,"metacyc":"RXN-10461","compounds":"H2O + O2 + spermidine => 3-aminopropanal + H2O2 + putrescine"}
{"X":28479,"RHEA_ID":25809,"DIRECTION":"LR","MASTER_ID":25808,"metacyc":"RXN-12089","compounds":"H2O + O2 + spermidine => 3-aminopropanal + H2O2 + putrescine"}
{"X":28480,"RHEA_ID":25810,"compounds":"3-aminopropanal + H2O2 + putrescine => H2O + O2 + spermidine"}
{"X":28481,"RHEA_ID":36370,"compounds":"(S)-alpha-hydroxyglutarate-gamma-lactone + H2O <=> 2-hydroxyglutarate + H(+)"}
{"X":28482,"RHEA_ID":25812,"DIRECTION":"UN","MASTER_ID":25812,"ec":"1.5.3.13","compounds":"H2O + N(1)-acetylspermidine + O2 = 3-acetamidopropanal + H2O2 + putrescine"}
{"X":28483,"RHEA_ID":25812,"DIRECTION":"UN","MASTER_ID":25812,"ec":"1.5.3.17","compounds":"H2O + N(1)-acetylspermidine + O2 = 3-acetamidopropanal + H2O2 + putrescine"}
{"X":28484,"RHEA_ID":25813,"DIRECTION":"LR","MASTER_ID":25812,"metacyc":"RXN-12091","reactome":"R-HSA-141348.1","compounds":"H2O + N(1)-acetylspermidine + O2 => 3-acetamidopropanal + H2O2 + putrescine"}
{"X":28485,"RHEA_ID":46296,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 6beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":28486,"RHEA_ID":25814,"compounds":"3-acetamidopropanal + H2O2 + putrescine => H2O + N(1)-acetylspermidine + O2"}
{"X":28487,"RHEA_ID":36376,"compounds":"ATP + carbamoyl phosphate + H2O => carbamoyl adenylate + diphosphate + phosphate"}
{"X":28488,"RHEA_ID":25816,"DIRECTION":"UN","MASTER_ID":25816,"ec":"1.5.3.16","compounds":"H2O + norspermine + O2 = 3-aminopropanal + H2O2 + norspermidine"}
{"X":28489,"RHEA_ID":46300,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 2-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":28490,"RHEA_ID":25818,"compounds":"3-aminopropanal + H2O2 + norspermidine => H2O + norspermine + O2"}
{"X":28491,"RHEA_ID":25819,"compounds":"H2O + norspermine + O2 <=> 3-aminopropanal + H2O2 + norspermidine"}
{"X":28492,"RHEA_ID":25820,"DIRECTION":"UN","MASTER_ID":25820,"ec":"1.5.3.14","compounds":"H2O + O2 + spermidine = 4-aminobutanal + H2O2 + propane-1,3-diamine"}
{"X":28493,"RHEA_ID":25821,"DIRECTION":"LR","MASTER_ID":25820,"metacyc":"RXN-10747","compounds":"H2O + O2 + spermidine => 4-aminobutanal + H2O2 + propane-1,3-diamine"}
{"X":28494,"RHEA_ID":36383,"compounds":"carbamoyl adenylate + tobramycin = AMP + H(+) + nebramycin 5'"}
{"X":28495,"RHEA_ID":25824,"DIRECTION":"UN","MASTER_ID":25824,"ec":"1.5.3.14","compounds":"H2O + O2 + spermine = H2O2 + N-(3-aminopropyl)-4-aminobutanal + propane-1,3-diamine"}
{"X":28496,"RHEA_ID":25825,"DIRECTION":"LR","MASTER_ID":25824,"metacyc":"RXN-6421","compounds":"H2O + O2 + spermine => H2O2 + N-(3-aminopropyl)-4-aminobutanal + propane-1,3-diamine"}
{"X":28497,"RHEA_ID":36387,"compounds":"carbamoyl adenylate + kanamycin A = 6''-O-carbamoylkanamycin A + AMP + H(+)"}
{"X":28498,"RHEA_ID":25827,"compounds":"H2O + O2 + spermine <=> H2O2 + N-(3-aminopropyl)-4-aminobutanal + propane-1,3-diamine"}
{"X":28499,"RHEA_ID":25828,"compounds":"AH2 + an N-acyl-(4R)-4-hydroxysphinganine + O2 = A + a (4R,8E)-4-hydroxysphingenine ceramide + 2 H2O"}
{"X":28500,"RHEA_ID":25829,"compounds":"AH2 + an N-acyl-(4R)-4-hydroxysphinganine + O2 => A + a (4R,8E)-4-hydroxysphingenine ceramide + 2 H2O"}
{"X":28501,"RHEA_ID":36391,"DIRECTION":"UN","MASTER_ID":36391,"ec":"1.3.1.72","compounds":"cholesterol + NADP(+) = cholesta-5,24-dien-3beta-ol + H(+) + NADPH"}
{"X":28502,"RHEA_ID":25831,"compounds":"AH2 + an N-acyl-(4R)-4-hydroxysphinganine + O2 <=> A + a (4R,8E)-4-hydroxysphingenine ceramide + 2 H2O"}
{"X":28503,"RHEA_ID":25832,"DIRECTION":"UN","MASTER_ID":25832,"ec":"1.1.1.369","compounds":"1D-chiro-inositol + NAD(+) = H(+) + NADH + scyllo-inosine"}
{"X":28504,"RHEA_ID":25833,"compounds":"1D-chiro-inositol + NAD(+) => H(+) + NADH + scyllo-inosine"}
{"X":28505,"RHEA_ID":36395,"DIRECTION":"UN","MASTER_ID":36395,"ec":"1.3.1.72","compounds":"cholesta-5,7-dien-3beta-ol + NADP(+) = cholesta-5,7,24-trien-3beta-ol + H(+) + NADPH"}
{"X":28506,"RHEA_ID":36396,"compounds":"cholesta-5,7-dien-3beta-ol + NADP(+) => cholesta-5,7,24-trien-3beta-ol + H(+) + NADPH"}
{"X":28507,"RHEA_ID":25836,"DIRECTION":"UN","MASTER_ID":25836,"ec":"3.7.1.22","compounds":"3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O = 5-deoxy-D-glucuronate + H(+)"}
{"X":28508,"RHEA_ID":25837,"DIRECTION":"LR","MASTER_ID":25836,"metacyc":"RXN-14149","compounds":"3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O => 5-deoxy-D-glucuronate + H(+)"}
{"X":28509,"RHEA_ID":25838,"compounds":"5-deoxy-D-glucuronate + H(+) => 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O"}
{"X":28510,"RHEA_ID":36400,"compounds":"5alpha-cholest-8-en-3beta-ol + NADP(+) => 5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADPH"}
{"X":28511,"RHEA_ID":25840,"DIRECTION":"UN","MASTER_ID":25840,"ec":"5.3.1.30","compounds":"5-deoxy-D-glucuronate = 5-dehydro-2-deoxy-D-gluconate"}
{"X":28512,"RHEA_ID":46324,"compounds":"3-oxochol-4-en-22-oyl-CoA + A = 3-oxochola-4,17-dien-22-oyl-CoA + AH2"}
{"X":28513,"RHEA_ID":25842,"compounds":"5-dehydro-2-deoxy-D-gluconate => 5-deoxy-D-glucuronate"}
{"X":28514,"RHEA_ID":36404,"compounds":"a cholesterol ester + H2O => a fatty acid + cholesterol + H(+)"}
{"X":28515,"RHEA_ID":25844,"DIRECTION":"UN","MASTER_ID":25844,"ec":"1.1.1.n4","compounds":"(1S,5R)-carveol + NAD(+) = (R)-carvone + H(+) + NADH"}
{"X":28516,"RHEA_ID":25845,"compounds":"(1S,5R)-carveol + NAD(+) => (R)-carvone + H(+) + NADH"}
{"X":28517,"RHEA_ID":25846,"compounds":"(R)-carvone + H(+) + NADH => (1S,5R)-carveol + NAD(+)"}
{"X":28518,"RHEA_ID":25847,"DIRECTION":"BI","MASTER_ID":25844,"metacyc":"RXN-14151","compounds":"(1S,5R)-carveol + NAD(+) <=> (R)-carvone + H(+) + NADH"}
{"X":28519,"RHEA_ID":25848,"DIRECTION":"UN","MASTER_ID":25848,"ec":"1.1.1.n4","compounds":"(1S,5S)-carveol + NAD(+) = (S)-carvone + H(+) + NADH"}
{"X":28520,"RHEA_ID":25849,"compounds":"(1S,5S)-carveol + NAD(+) => (S)-carvone + H(+) + NADH"}
{"X":28521,"RHEA_ID":36411,"compounds":"cholesta-5,7-dien-3beta-ol + hnu = calciol"}
{"X":28522,"RHEA_ID":25851,"compounds":"(1S,5S)-carveol + NAD(+) <=> (S)-carvone + H(+) + NADH"}
{"X":28523,"RHEA_ID":25852,"DIRECTION":"UN","MASTER_ID":25852,"ec":"1.14.19.5","compounds":"2 [Fe(II)-cytochrome b5] + an 11,12-saturated fatty acyl-CoA + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + an (11Z)-Delta(11)-fatty acyl-CoA + 2 H2O"}
{"X":28524,"RHEA_ID":25853,"DIRECTION":"LR","MASTER_ID":25852,"metacyc":"1.14.19.5-RXN","compounds":"2 [Fe(II)-cytochrome b5] + an 11,12-saturated fatty acyl-CoA + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + an (11Z)-Delta(11)-fatty acyl-CoA + 2 H2O"}
{"X":28525,"RHEA_ID":25854,"compounds":"2 [Fe(III)-cytochrome b5] + an (11Z)-Delta(11)-fatty acyl-CoA + 2 H2O => 2 [Fe(II)-cytochrome b5] + an 11,12-saturated fatty acyl-CoA + 2 H(+) + O2"}
{"X":28526,"RHEA_ID":25855,"compounds":"2 [Fe(II)-cytochrome b5] + an 11,12-saturated fatty acyl-CoA + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + an (11Z)-Delta(11)-fatty acyl-CoA + 2 H2O"}
{"X":28527,"RHEA_ID":25856,"DIRECTION":"UN","MASTER_ID":25856,"ec":"1.14.19.6","compounds":"(9Z)-octadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (9Z,12Z)-octadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":28528,"RHEA_ID":25857,"DIRECTION":"LR","MASTER_ID":25856,"metacyc":"RXN-9601","compounds":"(9Z)-octadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => (9Z,12Z)-octadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":28529,"RHEA_ID":25858,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => (9Z)-octadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}
{"X":28530,"RHEA_ID":25860,"DIRECTION":"UN","MASTER_ID":25860,"ec":"3.5.4.39","compounds":"GTP + H2O = 7,8-dihydroneopterin 2',3'-cyclic phosphate + diphosphate + formate + H(+)"}
{"X":28531,"RHEA_ID":25861,"DIRECTION":"LR","MASTER_ID":25860,"metacyc":"RXN-10063","compounds":"GTP + H2O => 7,8-dihydroneopterin 2',3'-cyclic phosphate + diphosphate + formate + H(+)"}
{"X":28532,"RHEA_ID":25862,"compounds":"7,8-dihydroneopterin 2',3'-cyclic phosphate + diphosphate + formate + H(+) => GTP + H2O"}
{"X":28533,"RHEA_ID":36424,"DIRECTION":"LR","MASTER_ID":36423,"metacyc":"RXN-11374","compounds":"2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine => 2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine"}
{"X":28534,"RHEA_ID":25864,"DIRECTION":"UN","MASTER_ID":25864,"ec":"1.5.3.15","compounds":"H2O + N(1)-acetylspermidine + O2 = 4-acetamidobutanal + H2O2 + propane-1,3-diamine"}
{"X":28535,"RHEA_ID":25865,"compounds":"H2O + N(1)-acetylspermidine + O2 => 4-acetamidobutanal + H2O2 + propane-1,3-diamine"}
{"X":28536,"RHEA_ID":25866,"compounds":"4-acetamidobutanal + H2O2 + propane-1,3-diamine => H2O + N(1)-acetylspermidine + O2"}
{"X":28537,"RHEA_ID":25867,"compounds":"H2O + N(1)-acetylspermidine + O2 <=> 4-acetamidobutanal + H2O2 + propane-1,3-diamine"}
{"X":28538,"RHEA_ID":36429,"compounds":"diphthine-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine => 2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine"}
{"X":28539,"RHEA_ID":25869,"DIRECTION":"LR","MASTER_ID":25868,"metacyc":"RXN-10460","compounds":"H2O + N(1),N(12)-diacetylspermine + O2 => 3-acetamidopropanal + H2O2 + N(1)-acetylspermidine"}
{"X":28540,"RHEA_ID":25870,"compounds":"3-acetamidopropanal + H2O2 + N(1)-acetylspermidine => H2O + N(1),N(12)-diacetylspermine + O2"}
{"X":28541,"RHEA_ID":25871,"compounds":"H2O + N(1),N(12)-diacetylspermine + O2 <=> 3-acetamidopropanal + H2O2 + N(1)-acetylspermidine"}
{"X":28542,"RHEA_ID":25872,"compounds":"H2O2 + pyridine = H2O + pyridine N-oxide"}
{"X":28543,"RHEA_ID":25873,"compounds":"H2O2 + pyridine => H2O + pyridine N-oxide"}
{"X":28544,"RHEA_ID":25874,"compounds":"H2O + pyridine N-oxide => H2O2 + pyridine"}
{"X":28545,"RHEA_ID":25875,"compounds":"H2O2 + pyridine <=> H2O + pyridine N-oxide"}
{"X":28546,"RHEA_ID":36437,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphate(out) => a 1,2-diacyl-sn-glycero-3-phosphate(in)"}
{"X":28547,"RHEA_ID":25877,"DIRECTION":"LR","MASTER_ID":25876,"ecocyc":"L-ASPARTATE-OXID-RXN","metacyc":"L-ASPARTATE-OXID-RXN","compounds":"L-aspartate + O2 => H2O2 + iminosuccinate"}
{"X":28548,"RHEA_ID":25878,"compounds":"H2O2 + iminosuccinate => L-aspartate + O2"}
{"X":28549,"RHEA_ID":36440,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ATP + H2O => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ADP + H(+) + phosphate"}
{"X":28550,"RHEA_ID":36441,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ADP + H(+) + phosphate => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ATP + H2O"}
{"X":28551,"RHEA_ID":25881,"DIRECTION":"LR","MASTER_ID":25880,"metacyc":"RXN-9773","compounds":"2 L-dopa + O2 => 2 3-(3,4-dihydroxyphenyl)pyruvate + 2 NH4(+)"}
{"X":28552,"RHEA_ID":25882,"compounds":"2 3-(3,4-dihydroxyphenyl)pyruvate + 2 NH4(+) => 2 L-dopa + O2"}
{"X":28553,"RHEA_ID":36444,"compounds":"dihydrochanoclavine-I aldehyde => 6,8-dimethyl-6,7-didehydroergoline + H2O"}
{"X":28554,"RHEA_ID":36445,"compounds":"6,8-dimethyl-6,7-didehydroergoline + H2O => dihydrochanoclavine-I aldehyde"}
{"X":28555,"RHEA_ID":25885,"compounds":"carbamoyl phosphate + N(2)-succinyl-L-ornithine => H(+) + N(2)-succinyl-L-citrulline + phosphate"}
{"X":28556,"RHEA_ID":25886,"compounds":"H(+) + N(2)-succinyl-L-citrulline + phosphate => carbamoyl phosphate + N(2)-succinyl-L-ornithine"}
{"X":28557,"RHEA_ID":25887,"compounds":"carbamoyl phosphate + N(2)-succinyl-L-ornithine <=> H(+) + N(2)-succinyl-L-citrulline + phosphate"}
{"X":28558,"RHEA_ID":36449,"compounds":"ADP + glycyl-L-proline(in) + H(+) + phosphate => ATP + glycyl-L-proline(out) + H2O"}
{"X":28559,"RHEA_ID":25889,"DIRECTION":"LR","MASTER_ID":25888,"ecocyc":"QUINOLINATE-SYNTHA-RXN","metacyc":"QUINOLINATE-SYNTHA-RXN","compounds":"dihydroxyacetone phosphate + iminosuccinate => H(+) + 2 H2O + phosphate + quinolinate"}
{"X":28560,"RHEA_ID":25890,"compounds":"H(+) + 2 H2O + phosphate + quinolinate => dihydroxyacetone phosphate + iminosuccinate"}
{"X":28561,"RHEA_ID":36452,"compounds":"ATP + glycyl-L-glutamate(out) + H2O => ADP + glycyl-L-glutamate(in) + H(+) + phosphate"}
{"X":28562,"RHEA_ID":25896,"DIRECTION":"UN","MASTER_ID":25896,"ec":"4.1.1.88","compounds":"H(+) + malonate = acetate + CO2"}
{"X":28563,"RHEA_ID":25897,"DIRECTION":"LR","MASTER_ID":25896,"metacyc":"RXN-19735","compounds":"H(+) + malonate => acetate + CO2"}
{"X":28564,"RHEA_ID":25898,"compounds":"acetate + CO2 => H(+) + malonate"}
{"X":28565,"RHEA_ID":36457,"compounds":"ADP + H(+) + L-alanylglycine(in) + phosphate => ATP + H2O + L-alanylglycine(out)"}
{"X":28566,"RHEA_ID":25901,"DIRECTION":"LR","MASTER_ID":25900,"metacyc":"R12-RXN","compounds":"D-arabino-hex-3-ulose 6-phosphate => beta-D-fructose 6-phosphate"}
{"X":28567,"RHEA_ID":25902,"compounds":"beta-D-fructose 6-phosphate => D-arabino-hex-3-ulose 6-phosphate"}
{"X":28568,"RHEA_ID":36460,"DIRECTION":"LR","MASTER_ID":36459,"metacyc":"RXN0-6988","compounds":"glycyl-L-proline + H2O => glycine + L-proline"}
{"X":28569,"RHEA_ID":36461,"compounds":"glycine + L-proline => glycyl-L-proline + H2O"}
{"X":28570,"RHEA_ID":25905,"DIRECTION":"LR","MASTER_ID":25904,"metacyc":"RXN-9780","compounds":"futalosine + H2O => dehypoxanthine futalosine + hypoxanthine"}
{"X":28571,"RHEA_ID":25906,"compounds":"dehypoxanthine futalosine + hypoxanthine => futalosine + H2O"}
{"X":28572,"RHEA_ID":25907,"compounds":"futalosine + H2O <=> dehypoxanthine futalosine + hypoxanthine"}
{"X":28573,"RHEA_ID":36465,"compounds":"glycine + L-glutamate => glycyl-L-glutamate + H2O"}
{"X":28574,"RHEA_ID":25909,"DIRECTION":"LR","MASTER_ID":25908,"metacyc":"RXN-9926","compounds":"an alditol + O2 => an aldose + H2O2"}
{"X":28575,"RHEA_ID":25910,"compounds":"an aldose + H2O2 => an alditol + O2"}
{"X":28576,"RHEA_ID":36468,"DIRECTION":"LR","MASTER_ID":36467,"metacyc":"RXN0-6977","compounds":"H2O + L-alanylglycine => glycine + L-alanine"}
{"X":28577,"RHEA_ID":36469,"compounds":"glycine + L-alanine => H2O + L-alanylglycine"}
{"X":28578,"RHEA_ID":25913,"compounds":"A + H2O + quinolin-5-ol => 5-hydroxyquinolin-2(1H)-one + AH2"}
{"X":28579,"RHEA_ID":25914,"compounds":"5-hydroxyquinolin-2(1H)-one + AH2 => A + H2O + quinolin-5-ol"}
{"X":28580,"RHEA_ID":25915,"compounds":"A + H2O + quinolin-5-ol <=> 5-hydroxyquinolin-2(1H)-one + AH2"}
{"X":28581,"RHEA_ID":25916,"DIRECTION":"UN","MASTER_ID":25916,"ec":"1.3.99.17","compounds":"A + H2O + quinolin-6-ol = 6-hydroxyquinolin-2(1H)-one + AH2"}
{"X":28582,"RHEA_ID":25917,"compounds":"A + H2O + quinolin-6-ol => 6-hydroxyquinolin-2(1H)-one + AH2"}
{"X":28583,"RHEA_ID":25918,"compounds":"6-hydroxyquinolin-2(1H)-one + AH2 => A + H2O + quinolin-6-ol"}
{"X":28584,"RHEA_ID":25919,"compounds":"A + H2O + quinolin-6-ol <=> 6-hydroxyquinolin-2(1H)-one + AH2"}
{"X":28585,"RHEA_ID":36477,"compounds":"(7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CO2 + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA"}
{"X":28586,"RHEA_ID":25921,"compounds":"A + H2O + quinolin-7-ol => 7-hydroxyquinolin-2(1H)-one + AH2"}
{"X":28587,"RHEA_ID":25922,"compounds":"7-hydroxyquinolin-2(1H)-one + AH2 => A + H2O + quinolin-7-ol"}
{"X":28588,"RHEA_ID":25923,"compounds":"A + H2O + quinolin-7-ol <=> 7-hydroxyquinolin-2(1H)-one + AH2"}
{"X":28589,"RHEA_ID":36481,"compounds":"(9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + CO2 + CoA => (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA"}
{"X":28590,"RHEA_ID":25925,"compounds":"A + H2O + quinolin-8-ol => 8-hydroxyquinolin-2(1H)-one + AH2"}
{"X":28591,"RHEA_ID":25926,"compounds":"8-hydroxyquinolin-2(1H)-one + AH2 => A + H2O + quinolin-8-ol"}
{"X":28592,"RHEA_ID":25927,"compounds":"A + H2O + quinolin-8-ol <=> 8-hydroxyquinolin-2(1H)-one + AH2"}
{"X":28593,"RHEA_ID":36485,"compounds":"(7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + CO2 + CoA => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + malonyl-CoA"}
{"X":28594,"RHEA_ID":25929,"DIRECTION":"LR","MASTER_ID":25928,"metacyc":"RXN-641","compounds":"3-methylquinoline + A + H2O => 3-methylquinolin-2(1H)-one + AH2"}
{"X":28595,"RHEA_ID":25930,"compounds":"3-methylquinolin-2(1H)-one + AH2 => 3-methylquinoline + A + H2O"}
{"X":28596,"RHEA_ID":25931,"compounds":"3-methylquinoline + A + H2O <=> 3-methylquinolin-2(1H)-one + AH2"}
{"X":28597,"RHEA_ID":25932,"DIRECTION":"UN","MASTER_ID":25932,"ec":"1.3.99.17","compounds":"4-methylquinoline + A + H2O = 4-methylquinolin-2(1H)-one + AH2"}
{"X":28598,"RHEA_ID":25933,"compounds":"4-methylquinoline + A + H2O => 4-methylquinolin-2(1H)-one + AH2"}
{"X":28599,"RHEA_ID":25934,"compounds":"4-methylquinolin-2(1H)-one + AH2 => 4-methylquinoline + A + H2O"}
{"X":28600,"RHEA_ID":25935,"compounds":"4-methylquinoline + A + H2O <=> 4-methylquinolin-2(1H)-one + AH2"}
{"X":28601,"RHEA_ID":36493,"compounds":"(9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + CO2 + CoA => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + H(+) + malonyl-CoA"}
{"X":28602,"RHEA_ID":25937,"compounds":"8-methylquinoline + A + H2O => 8-methylquinolin-2(1H)-one + AH2"}
{"X":28603,"RHEA_ID":25938,"compounds":"8-methylquinolin-2(1H)-one + AH2 => 8-methylquinoline + A + H2O"}
{"X":28604,"RHEA_ID":25939,"DIRECTION":"BI","MASTER_ID":25936,"metacyc":"RXN-14156","compounds":"8-methylquinoline + A + H2O <=> 8-methylquinolin-2(1H)-one + AH2"}
{"X":28605,"RHEA_ID":36497,"compounds":"ADP + alpha-D-glucose 6-phosphate + H(+) => alpha-D-glucose + ATP"}
{"X":28606,"RHEA_ID":25941,"compounds":"8-chloroquinoline + A + H2O => 8-chloroquinolin-2(1H)-one + AH2"}
{"X":28607,"RHEA_ID":25942,"compounds":"8-chloroquinolin-2(1H)-one + AH2 => 8-chloroquinoline + A + H2O"}
{"X":28608,"RHEA_ID":25943,"compounds":"8-chloroquinoline + A + H2O <=> 8-chloroquinolin-2(1H)-one + AH2"}
{"X":28609,"RHEA_ID":36501,"compounds":"2,4-didehydro-3-deoxy-L-rhamnonate + H(+) + NADH => 2-dehydro-3-deoxy-L-rhamnonate + NAD(+)"}
{"X":28610,"RHEA_ID":25949,"DIRECTION":"LR","MASTER_ID":25948,"metacyc":"RXN-12959","compounds":"a 1,2-diacyl-sn-glycerol + CTP => a 1,2-diacyl-sn-glycero-3-phosphate + CDP + H(+)"}
{"X":28611,"RHEA_ID":25950,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphate + CDP + H(+) => a 1,2-diacyl-sn-glycerol + CTP"}
{"X":28612,"RHEA_ID":36504,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + H(+) + malonyl-CoA => (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA"}
{"X":28613,"RHEA_ID":36505,"compounds":"(11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA => (9Z,12Z)-octadecadienoyl-CoA + H(+) + malonyl-CoA"}
{"X":28614,"RHEA_ID":25953,"DIRECTION":"LR","MASTER_ID":25952,"metacyc":"RXN-10031","compounds":"1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + L-aspartate 4-semialdehyde => 2,3-dioxopropyl phosphate + 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate"}
{"X":28615,"RHEA_ID":25954,"compounds":"2,3-dioxopropyl phosphate + 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate => 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + L-aspartate 4-semialdehyde"}
{"X":28616,"RHEA_ID":36508,"compounds":"docosanoyl-CoA + H(+) + malonyl-CoA => 3-oxotetracosanoyl-CoA + CO2 + CoA"}
{"X":28617,"RHEA_ID":36509,"compounds":"3-oxotetracosanoyl-CoA + CO2 + CoA => docosanoyl-CoA + H(+) + malonyl-CoA"}
{"X":28618,"RHEA_ID":25957,"compounds":"2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) => 3-dehydroquinate + H(+) + NADH + NH4(+)"}
{"X":28619,"RHEA_ID":25958,"compounds":"3-dehydroquinate + H(+) + NADH + NH4(+) => 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+)"}
{"X":28620,"RHEA_ID":36512,"compounds":"(9Z)-octadecenoyl-CoA + H(+) + malonyl-CoA => (11Z)-3-oxoicosenoyl-CoA + CO2 + CoA"}
{"X":28621,"RHEA_ID":36513,"compounds":"(11Z)-3-oxoicosenoyl-CoA + CO2 + CoA => (9Z)-octadecenoyl-CoA + H(+) + malonyl-CoA"}
{"X":28622,"RHEA_ID":25961,"compounds":"benzoin + NADP(+) => benzil + H(+) + NADPH"}
{"X":28623,"RHEA_ID":25962,"compounds":"benzil + H(+) + NADPH => benzoin + NADP(+)"}
{"X":28624,"RHEA_ID":25963,"compounds":"benzoin + NADP(+) <=> benzil + H(+) + NADPH"}
{"X":28625,"RHEA_ID":25964,"DIRECTION":"UN","MASTER_ID":25964,"ec":"1.1.1.321","metacyc":"RXN-12897","compounds":"(R)-benzoin + NADP(+) = benzil + H(+) + NADPH"}
{"X":28626,"RHEA_ID":25965,"compounds":"(R)-benzoin + NADP(+) => benzil + H(+) + NADPH"}
{"X":28627,"RHEA_ID":25966,"compounds":"benzil + H(+) + NADPH => (R)-benzoin + NADP(+)"}
{"X":28628,"RHEA_ID":36520,"compounds":"H(+) + hexacosanoyl-CoA + malonyl-CoA => 3-oxooctacosanyol-CoA + CO2 + CoA"}
{"X":28629,"RHEA_ID":36521,"compounds":"3-oxooctacosanyol-CoA + CO2 + CoA => H(+) + hexacosanoyl-CoA + malonyl-CoA"}
{"X":28630,"RHEA_ID":25969,"compounds":"(S)-benzoin + NADP(+) => benzil + H(+) + NADPH"}
{"X":28631,"RHEA_ID":25970,"compounds":"benzil + H(+) + NADPH => (S)-benzoin + NADP(+)"}
{"X":28632,"RHEA_ID":36524,"compounds":"(9Z,12Z,15Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA => (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA"}
{"X":28633,"RHEA_ID":25972,"DIRECTION":"UN","MASTER_ID":25972,"ec":"1.5.3.17","compounds":"H2O + N(8)-acetylspermidine + O2 = 4-acetamidobutanal + H2O2 + propane-1,3-diamine"}
{"X":28634,"RHEA_ID":36526,"compounds":"(9Z,12Z,15Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA <=> (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA"}
{"X":28635,"RHEA_ID":25973,"DIRECTION":"LR","MASTER_ID":25972,"metacyc":"RXN-10463","compounds":"H2O + N(8)-acetylspermidine + O2 => 4-acetamidobutanal + H2O2 + propane-1,3-diamine"}
{"X":28636,"RHEA_ID":25974,"compounds":"4-acetamidobutanal + H2O2 + propane-1,3-diamine => H2O + N(8)-acetylspermidine + O2"}
{"X":28637,"RHEA_ID":36529,"compounds":"(13Z)-3-oxodocosenoyl-CoA + CO2 + CoA => (11Z)-eicosenoyl-CoA + H(+) + malonyl-CoA"}
{"X":28638,"RHEA_ID":25976,"compounds":"(+)-epi-isozizaene + H(+) + NADPH + O2 = (5S)-albaflavenol + H2O + NADP(+)"}
{"X":28639,"RHEA_ID":25977,"DIRECTION":"LR","MASTER_ID":25976,"metacyc":"RXN-9350","compounds":"(+)-epi-isozizaene + H(+) + NADPH + O2 => (5S)-albaflavenol + H2O + NADP(+)"}
{"X":28640,"RHEA_ID":25978,"compounds":"(5S)-albaflavenol + H2O + NADP(+) => (+)-epi-isozizaene + H(+) + NADPH + O2"}
{"X":28641,"RHEA_ID":36533,"compounds":"(15Z)-3-oxotetracosenoyl-CoA + CO2 + CoA => (13Z)-docosenoyl-CoA + H(+) + malonyl-CoA"}
{"X":28642,"RHEA_ID":25980,"compounds":"(5S)-albaflavenol + H(+) + NADPH + O2 = albaflavenone + 2 H2O + NADP(+)"}
{"X":28643,"RHEA_ID":36535,"compounds":"docosanoyl-CoA + sphinganine = CoA + H(+) + N-docosanoylsphinganine"}
{"X":28644,"RHEA_ID":25982,"compounds":"albaflavenone + 2 H2O + NADP(+) => (5S)-albaflavenol + H(+) + NADPH + O2"}
{"X":28645,"RHEA_ID":36537,"compounds":"CoA + H(+) + N-docosanoylsphinganine => docosanoyl-CoA + sphinganine"}
{"X":28646,"RHEA_ID":25984,"compounds":"(+)-epi-isozizaene + H(+) + NADPH + O2 = (5R)-albaflavenol + H2O + NADP(+)"}
{"X":28647,"RHEA_ID":36539,"compounds":"hexadecanoyl-CoA + sphinganine = CoA + H(+) + N-hexadecanoylsphinganine"}
{"X":28648,"RHEA_ID":25986,"compounds":"(5R)-albaflavenol + H2O + NADP(+) => (+)-epi-isozizaene + H(+) + NADPH + O2"}
{"X":28649,"RHEA_ID":36541,"compounds":"CoA + H(+) + N-hexadecanoylsphinganine => hexadecanoyl-CoA + sphinganine"}
{"X":28650,"RHEA_ID":25988,"compounds":"(5R)-albaflavenol + H(+) + NADPH + O2 = albaflavenone + 2 H2O + NADP(+)"}
{"X":28651,"RHEA_ID":36543,"DIRECTION":"UN","MASTER_ID":36543,"ec":"3.5.1.115","compounds":"H2O + mycothiol S-conjugate = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + an N-acetyl-L-cysteine-S-conjugate"}
{"X":28652,"RHEA_ID":25990,"compounds":"albaflavenone + 2 H2O + NADP(+) => (5R)-albaflavenol + H(+) + NADPH + O2"}
{"X":28653,"RHEA_ID":36545,"compounds":"1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + an N-acetyl-L-cysteine-S-conjugate => H2O + mycothiol S-conjugate"}
{"X":28654,"RHEA_ID":25992,"DIRECTION":"UN","MASTER_ID":25992,"ec":"4.2.3.37","compounds":"(2E,6E)-farnesyl diphosphate = (+)-epi-isozizaene + diphosphate"}
{"X":28655,"RHEA_ID":25993,"DIRECTION":"LR","MASTER_ID":25992,"metacyc":"RXN-9349","compounds":"(2E,6E)-farnesyl diphosphate => (+)-epi-isozizaene + diphosphate"}
{"X":28656,"RHEA_ID":25994,"compounds":"(+)-epi-isozizaene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":28657,"RHEA_ID":36549,"compounds":"CoA + H(+) + N-(octadecanoyl)-sphinganine => octadecanoyl-CoA + sphinganine"}
{"X":28658,"RHEA_ID":25996,"DIRECTION":"UN","MASTER_ID":25996,"ec":"1.5.3.14","compounds":"H2O + N(1)-acetylspermine + O2 = H2O2 + N-(3-acetamidopropyl)-4-aminobutanal + propane-1,3-diamine"}
{"X":28659,"RHEA_ID":25997,"DIRECTION":"LR","MASTER_ID":25996,"metacyc":"RXN-10465","compounds":"H2O + N(1)-acetylspermine + O2 => H2O2 + N-(3-acetamidopropyl)-4-aminobutanal + propane-1,3-diamine"}
{"X":28660,"RHEA_ID":36556,"compounds":"eicosanoyl-CoA + sphinganine => CoA + H(+) + N-eicosanoylsphinganine"}
{"X":28661,"RHEA_ID":25999,"compounds":"H2O + N(1)-acetylspermine + O2 <=> H2O2 + N-(3-acetamidopropyl)-4-aminobutanal + propane-1,3-diamine"}
{"X":28662,"RHEA_ID":26002,"DIRECTION":"UN","MASTER_ID":26002,"ec":"1.1.1.301","compounds":"D-arabinitol 1-phosphate + NAD(+) = D-xylulose 5-phosphate + H(+) + NADH"}
{"X":28663,"RHEA_ID":26003,"compounds":"D-arabinitol 1-phosphate + NAD(+) => D-xylulose 5-phosphate + H(+) + NADH"}
{"X":28664,"RHEA_ID":36560,"DIRECTION":"LR","MASTER_ID":36559,"metacyc":"RXN-8003","compounds":"A + cis-4-hydroxy-D-proline => 4-hydroxy-1-pyrroline-2-carboxylate + AH2 + H(+)"}
{"X":28665,"RHEA_ID":36561,"compounds":"4-hydroxy-1-pyrroline-2-carboxylate + AH2 + H(+) => A + cis-4-hydroxy-D-proline"}
{"X":28666,"RHEA_ID":26006,"compounds":"di-trans,nona-cis-dodecaprenyl phosphate + UDP-alpha-D-galacturonate = beta-D-galacturonosyl di-trans,nona-cis-dodecaprenyl phosphate + UDP"}
{"X":28667,"RHEA_ID":26007,"compounds":"di-trans,nona-cis-dodecaprenyl phosphate + UDP-alpha-D-galacturonate => beta-D-galacturonosyl di-trans,nona-cis-dodecaprenyl phosphate + UDP"}
{"X":28668,"RHEA_ID":36564,"compounds":"GDP-beta-L-colitose + NADP(+) => GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADPH"}
{"X":28669,"RHEA_ID":26009,"compounds":"di-trans,nona-cis-dodecaprenyl phosphate + UDP-alpha-D-galacturonate <=> beta-D-galacturonosyl di-trans,nona-cis-dodecaprenyl phosphate + UDP"}
{"X":28670,"RHEA_ID":26010,"compounds":"2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) = 3,7-dideoxy-D-threo-hepto-2,6-diuolosonate + H(+) + NADH + NH4(+)"}
{"X":28671,"RHEA_ID":26011,"compounds":"2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) => 3,7-dideoxy-D-threo-hepto-2,6-diuolosonate + H(+) + NADH + NH4(+)"}
{"X":28672,"RHEA_ID":26012,"compounds":"3,7-dideoxy-D-threo-hepto-2,6-diuolosonate + H(+) + NADH + NH4(+) => 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+)"}
{"X":28673,"RHEA_ID":26013,"compounds":"2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) <=> 3,7-dideoxy-D-threo-hepto-2,6-diuolosonate + H(+) + NADH + NH4(+)"}
{"X":28674,"RHEA_ID":26014,"compounds":"3,7-dideoxy-D-threo-hepto-2,6-diuolosonate = 3-dehydroquinate"}
{"X":28675,"RHEA_ID":26015,"compounds":"3,7-dideoxy-D-threo-hepto-2,6-diuolosonate => 3-dehydroquinate"}
{"X":28676,"RHEA_ID":36572,"compounds":"sphinganine + tetradecanoyl-CoA => CoA + H(+) + N-(tetradecanoyl)-sphinganine"}
{"X":28677,"RHEA_ID":26017,"compounds":"3,7-dideoxy-D-threo-hepto-2,6-diuolosonate <=> 3-dehydroquinate"}
{"X":28678,"RHEA_ID":26019,"DIRECTION":"UN","MASTER_ID":26019,"ec":"3.1.3.79","compounds":"beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + H2O = beta-D-fructofuranosyl alpha-D-mannopyranoside + phosphate"}
{"X":28679,"RHEA_ID":26020,"DIRECTION":"LR","MASTER_ID":26019,"metacyc":"RXN-9936","compounds":"beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + H2O => beta-D-fructofuranosyl alpha-D-mannopyranoside + phosphate"}
{"X":28680,"RHEA_ID":36576,"compounds":"(9Z)-octadecenoyl-CoA + sphinganine => CoA + H(+) + N-(9Z-octadecenoyl)-sphinganine"}
{"X":28681,"RHEA_ID":36577,"compounds":"CoA + H(+) + N-(9Z-octadecenoyl)-sphinganine => (9Z)-octadecenoyl-CoA + sphinganine"}
{"X":28682,"RHEA_ID":26023,"DIRECTION":"UN","MASTER_ID":26023,"ec":"1.13.11.67","compounds":"8'-apo-beta-carotenol + O2 = (3E,5E)-7-hydroxy-6-methylhepta-3,5-dienal + 14'-apo-beta-carotenal"}
{"X":28683,"RHEA_ID":26024,"DIRECTION":"LR","MASTER_ID":26023,"metacyc":"1.13.12.12-RXN","compounds":"8'-apo-beta-carotenol + O2 => (3E,5E)-7-hydroxy-6-methylhepta-3,5-dienal + 14'-apo-beta-carotenal"}
{"X":28684,"RHEA_ID":26025,"compounds":"(3E,5E)-7-hydroxy-6-methylhepta-3,5-dienal + 14'-apo-beta-carotenal => 8'-apo-beta-carotenol + O2"}
{"X":28685,"RHEA_ID":36581,"DIRECTION":"RL","MASTER_ID":36579,"metacyc":"RXN-14532","compounds":"dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH => dTDP-alpha-D-fucose + NAD(+)"}
{"X":28686,"RHEA_ID":26027,"compounds":"H2O + N(1)-acetylspermidine + O2 = 3-aminopropanal + H2O2 + N-acetylputrescine"}
{"X":28687,"RHEA_ID":26028,"compounds":"H2O + N(1)-acetylspermidine + O2 => 3-aminopropanal + H2O2 + N-acetylputrescine"}
{"X":28688,"RHEA_ID":26029,"compounds":"3-aminopropanal + H2O2 + N-acetylputrescine => H2O + N(1)-acetylspermidine + O2"}
{"X":28689,"RHEA_ID":26030,"compounds":"H2O + N(1)-acetylspermidine + O2 <=> 3-aminopropanal + H2O2 + N-acetylputrescine"}
{"X":28690,"RHEA_ID":26031,"DIRECTION":"UN","MASTER_ID":26031,"ec":"1.14.19.69","compounds":"2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,3'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":28691,"RHEA_ID":26032,"DIRECTION":"LR","MASTER_ID":26031,"metacyc":"RXN-9932","compounds":"2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3,3'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":28692,"RHEA_ID":26033,"compounds":"3,3'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":28693,"RHEA_ID":36589,"compounds":"aldono-1,5-lactone + H(+) + NADPH => an aldopyranose + NADP(+)"}
{"X":28694,"RHEA_ID":26035,"DIRECTION":"UN","MASTER_ID":26035,"ec":"1.14.19.69","compounds":"2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,8'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":28695,"RHEA_ID":26036,"DIRECTION":"LR","MASTER_ID":26035,"metacyc":"RXN-9933","compounds":"2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3,8'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":28696,"RHEA_ID":36592,"compounds":"(S)-2-chloropropanoate + NADP(+) => 2-chloroacrylate + H(+) + NADPH"}
{"X":28697,"RHEA_ID":36593,"DIRECTION":"RL","MASTER_ID":36591,"metacyc":"RXN-14536","compounds":"2-chloroacrylate + H(+) + NADPH => (S)-2-chloropropanoate + NADP(+)"}
{"X":28698,"RHEA_ID":26039,"DIRECTION":"UN","MASTER_ID":26039,"ec":"2.4.1.246","compounds":"beta-D-fructose 6-phosphate + GDP-alpha-D-mannose = beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + GDP + H(+)"}
{"X":28699,"RHEA_ID":26040,"DIRECTION":"LR","MASTER_ID":26039,"metacyc":"RXN-9935","compounds":"beta-D-fructose 6-phosphate + GDP-alpha-D-mannose => beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + GDP + H(+)"}
{"X":28700,"RHEA_ID":26041,"compounds":"beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + GDP + H(+) => beta-D-fructose 6-phosphate + GDP-alpha-D-mannose"}
{"X":28701,"RHEA_ID":36597,"DIRECTION":"RL","MASTER_ID":36595,"metacyc":"RXN-14537","compounds":"NADPH + sulfur => hydrogen sulfide + NADP(+)"}
{"X":28702,"RHEA_ID":26043,"DIRECTION":"UN","MASTER_ID":26043,"ec":"2.3.1.45","compounds":"acetyl-CoA + N-acetylneuraminate = CoA + N-acetyl-9-O-acetylneuraminate"}
{"X":28703,"RHEA_ID":26044,"compounds":"acetyl-CoA + N-acetylneuraminate => CoA + N-acetyl-9-O-acetylneuraminate"}
{"X":28704,"RHEA_ID":36600,"compounds":"hydrogen sulfide + NAD(+) => NADH + sulfur"}
{"X":28705,"RHEA_ID":36601,"DIRECTION":"RL","MASTER_ID":36599,"metacyc":"RXN-14537","compounds":"NADH + sulfur => hydrogen sulfide + NAD(+)"}
{"X":28706,"RHEA_ID":26047,"DIRECTION":"UN","MASTER_ID":26047,"ec":"1.14.14.135","compounds":"(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] = glyceollin II + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":28707,"RHEA_ID":26048,"DIRECTION":"LR","MASTER_ID":26047,"metacyc":"RXN-4512","compounds":"(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] => glyceollin II + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":28708,"RHEA_ID":26049,"compounds":"glyceollin II + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":28709,"RHEA_ID":36605,"compounds":"(3S)-3-hydroxy-L-enduracididine + CO2 + succinate => 2-oxoglutarate + L-enduracididine + O2"}
{"X":28710,"RHEA_ID":26051,"DIRECTION":"UN","MASTER_ID":26051,"ec":"1.14.14.135","compounds":"(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] = glyceollin III + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":28711,"RHEA_ID":26052,"DIRECTION":"LR","MASTER_ID":26051,"metacyc":"RXN-4513","compounds":"(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] => glyceollin III + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":28712,"RHEA_ID":36608,"DIRECTION":"LR","MASTER_ID":36607,"metacyc":"RXN-14542","compounds":"2-oxoglutarate + L-arginine + O2 => (2S,3S)-hydroxyarginine + CO2 + succinate"}
{"X":28713,"RHEA_ID":36609,"compounds":"(2S,3S)-hydroxyarginine + CO2 + succinate => 2-oxoglutarate + L-arginine + O2"}
{"X":28714,"RHEA_ID":26055,"DIRECTION":"UN","MASTER_ID":26055,"ec":"2.7.7.91","compounds":"GTP + H(+) + valienol 1-phosphate = diphosphate + GDP-valienol"}
{"X":28715,"RHEA_ID":26056,"DIRECTION":"LR","MASTER_ID":26055,"metacyc":"RXN-17377","compounds":"GTP + H(+) + valienol 1-phosphate => diphosphate + GDP-valienol"}
{"X":28716,"RHEA_ID":36612,"DIRECTION":"LR","MASTER_ID":36611,"metacyc":"RXN-8949","compounds":"(3S,5S)-carbapenam-3-caboxylate + 2-oxoglutarate + O2 => (5R)-carbapenem-3-carboxylate + CO2 + H2O + succinate"}
{"X":28717,"RHEA_ID":36613,"compounds":"(5R)-carbapenem-3-carboxylate + CO2 + H2O + succinate => (3S,5S)-carbapenam-3-caboxylate + 2-oxoglutarate + O2"}
{"X":28718,"RHEA_ID":26059,"DIRECTION":"UN","MASTER_ID":26059,"ec":"2.1.1.248","compounds":"[Co(I) methylamine-specific corrinoid protein] + H(+) + methylamine = [methyl-Co(III) methylamine-specific corrinoid protein] + NH4(+)"}
{"X":28719,"RHEA_ID":26060,"DIRECTION":"LR","MASTER_ID":26059,"metacyc":"RXN-8098","compounds":"[Co(I) methylamine-specific corrinoid protein] + H(+) + methylamine => [methyl-Co(III) methylamine-specific corrinoid protein] + NH4(+)"}
{"X":28720,"RHEA_ID":26061,"compounds":"[methyl-Co(III) methylamine-specific corrinoid protein] + NH4(+) => [Co(I) methylamine-specific corrinoid protein] + H(+) + methylamine"}
{"X":28721,"RHEA_ID":36617,"compounds":"CoA + H(+) + N-(2-hydroxyoctadecanoyl)sphinganine => 2-hydroxyoctadecanoyl-CoA + sphinganine"}
{"X":28722,"RHEA_ID":26064,"DIRECTION":"UN","MASTER_ID":26064,"ec":"2.7.1.163","compounds":"ATP + hygromycin B = 4-O-phosphohygromycin B + ADP + H(+)"}
{"X":28723,"RHEA_ID":26065,"compounds":"ATP + hygromycin B => 4-O-phosphohygromycin B + ADP + H(+)"}
{"X":28724,"RHEA_ID":26066,"compounds":"4-O-phosphohygromycin B + ADP + H(+) => ATP + hygromycin B"}
{"X":28725,"RHEA_ID":46543,"compounds":"(6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a (9Z,12Z,15Z)-octadeca-9,12,15-trien-6-ynoyl-containing glycerolipid + 2 H2O"}
{"X":28726,"RHEA_ID":26068,"DIRECTION":"UN","MASTER_ID":26068,"ec":"2.3.3.18","compounds":"3-(hydrohydroxyphosphoryl)pyruvate + acetyl-CoA + H2O = CoA + H(+) + phosphinomethylmalate"}
{"X":28727,"RHEA_ID":26069,"DIRECTION":"LR","MASTER_ID":26068,"metacyc":"RXN-10829","compounds":"3-(hydrohydroxyphosphoryl)pyruvate + acetyl-CoA + H2O => CoA + H(+) + phosphinomethylmalate"}
{"X":28728,"RHEA_ID":26070,"compounds":"CoA + H(+) + phosphinomethylmalate => 3-(hydrohydroxyphosphoryl)pyruvate + acetyl-CoA + H2O"}
{"X":28729,"RHEA_ID":36625,"compounds":"(3S)-2-oxo-3-phenylbutanoate + H(+) + S-adenosyl-L-homocysteine => 3-phenylpyruvate + S-adenosyl-L-methionine"}
{"X":28730,"RHEA_ID":26073,"compounds":"H2O + UDP-alpha-D-glucuronate = D-glucuronate + H(+) + UDP"}
{"X":28731,"RHEA_ID":26074,"DIRECTION":"LR","MASTER_ID":26073,"metacyc":"RXN3DJ-64","compounds":"H2O + UDP-alpha-D-glucuronate => D-glucuronate + H(+) + UDP"}
{"X":28732,"RHEA_ID":26075,"compounds":"D-glucuronate + H(+) + UDP => H2O + UDP-alpha-D-glucuronate"}
{"X":28733,"RHEA_ID":26077,"DIRECTION":"UN","MASTER_ID":26077,"ec":"1.14.13.111","compounds":"methanesulfonate + NADH + O2 = formaldehyde + H2O + NAD(+) + sulfite"}
{"X":28734,"RHEA_ID":26078,"DIRECTION":"LR","MASTER_ID":26077,"metacyc":"RXN-9770","compounds":"methanesulfonate + NADH + O2 => formaldehyde + H2O + NAD(+) + sulfite"}
{"X":28735,"RHEA_ID":26079,"compounds":"formaldehyde + H2O + NAD(+) + sulfite => methanesulfonate + NADH + O2"}
{"X":28736,"RHEA_ID":36633,"compounds":"(2R)-3-phosphoglycerate + 2-phosphoglycolate + 2 H(+) => D-ribulose 1,5-bisphosphate + O2"}
{"X":28737,"RHEA_ID":26081,"DIRECTION":"UN","MASTER_ID":26081,"ec":"4.2.3.40","compounds":"(2E,6E)-farnesyl diphosphate = (Z)-gamma-bisabolene + diphosphate"}
{"X":28738,"RHEA_ID":26082,"DIRECTION":"LR","MASTER_ID":26081,"metacyc":"RXN-10005","compounds":"(2E,6E)-farnesyl diphosphate => (Z)-gamma-bisabolene + diphosphate"}
{"X":28739,"RHEA_ID":26083,"compounds":"(Z)-gamma-bisabolene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":28740,"RHEA_ID":56580,"DIRECTION":"UN","MASTER_ID":56580,"ec":"2.1.1.67","compounds":"6-thioguanine + S-adenosyl-L-methionine = 6-methylthioguanine + H(+) + S-adenosyl-L-homocysteine"}
{"X":28741,"RHEA_ID":26085,"DIRECTION":"UN","MASTER_ID":26085,"ec":"1.14.13.107","compounds":"(4S)-limonene + H(+) + NADPH + O2 = H2O + limonene 1,2-epoxide + NADP(+)"}
{"X":28742,"RHEA_ID":26086,"DIRECTION":"LR","MASTER_ID":26085,"metacyc":"RXN-9409","compounds":"(4S)-limonene + H(+) + NADPH + O2 => H2O + limonene 1,2-epoxide + NADP(+)"}
{"X":28743,"RHEA_ID":26087,"compounds":"H2O + limonene 1,2-epoxide + NADP(+) => (4S)-limonene + H(+) + NADPH + O2"}
{"X":28744,"RHEA_ID":56584,"compounds":"1,2-epoxypropane + H2O = propane-1,2-diol"}
{"X":28745,"RHEA_ID":26089,"DIRECTION":"UN","MASTER_ID":26089,"ec":"1.14.13.107","compounds":"(4S)-limonene + H(+) + NADH + O2 = H2O + limonene 1,2-epoxide + NAD(+)"}
{"X":28746,"RHEA_ID":26090,"DIRECTION":"LR","MASTER_ID":26089,"metacyc":"RXN-9409","compounds":"(4S)-limonene + H(+) + NADH + O2 => H2O + limonene 1,2-epoxide + NAD(+)"}
{"X":28747,"RHEA_ID":26091,"compounds":"H2O + limonene 1,2-epoxide + NAD(+) => (4S)-limonene + H(+) + NADH + O2"}
{"X":28748,"RHEA_ID":36645,"compounds":"H(+) + questin + S-adenosyl-L-homocysteine => emodin + S-adenosyl-L-methionine"}
{"X":28749,"RHEA_ID":26093,"DIRECTION":"UN","MASTER_ID":26093,"ec":"1.14.13.107","compounds":"(4R)-limonene + H(+) + NADH + O2 = H2O + limonene 1,2-epoxide + NAD(+)"}
{"X":28750,"RHEA_ID":26094,"DIRECTION":"LR","MASTER_ID":26093,"metacyc":"RXN-9407","compounds":"(4R)-limonene + H(+) + NADH + O2 => H2O + limonene 1,2-epoxide + NAD(+)"}
{"X":28751,"RHEA_ID":26095,"compounds":"H2O + limonene 1,2-epoxide + NAD(+) => (4R)-limonene + H(+) + NADH + O2"}
{"X":28752,"RHEA_ID":36649,"compounds":"CoA + H(+) + N-(2-hydroxyhexadecanoyl)-sphinganine => 2-hydroxyhexadecanoyl-CoA + sphinganine"}
{"X":28753,"RHEA_ID":26097,"DIRECTION":"UN","MASTER_ID":26097,"ec":"1.14.13.107","compounds":"(4R)-limonene + H(+) + NADPH + O2 = H2O + limonene 1,2-epoxide + NADP(+)"}
{"X":28754,"RHEA_ID":26098,"DIRECTION":"LR","MASTER_ID":26097,"metacyc":"RXN-9407","compounds":"(4R)-limonene + H(+) + NADPH + O2 => H2O + limonene 1,2-epoxide + NADP(+)"}
{"X":28755,"RHEA_ID":26099,"compounds":"H2O + limonene 1,2-epoxide + NADP(+) => (4R)-limonene + H(+) + NADPH + O2"}
{"X":28756,"RHEA_ID":36653,"compounds":"H(+) + novobiocic acid + S-adenosyl-L-homocysteine => 8-desmethylnovobiocic acid + S-adenosyl-L-methionine"}
{"X":28757,"RHEA_ID":26101,"compounds":"(2R)-homocitrate = cis-homoaconitate + H2O"}
{"X":28758,"RHEA_ID":26102,"DIRECTION":"LR","MASTER_ID":26101,"metacyc":"RXN3O-1983","compounds":"(2R)-homocitrate => cis-homoaconitate + H2O"}
{"X":28759,"RHEA_ID":26103,"compounds":"cis-homoaconitate + H2O => (2R)-homocitrate"}
{"X":28760,"RHEA_ID":56600,"DIRECTION":"UN","MASTER_ID":56600,"ec":"2.4.2.n3","compounds":"3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-threonyl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-threonyl-[EGF-like domain protein] + H(+) + UDP"}
{"X":28761,"RHEA_ID":26105,"compounds":"homocitrate = cis-homoaconitate + H2O"}
{"X":28762,"RHEA_ID":26106,"compounds":"homocitrate => cis-homoaconitate + H2O"}
{"X":28763,"RHEA_ID":26107,"compounds":"cis-homoaconitate + H2O => homocitrate"}
{"X":28764,"RHEA_ID":36661,"compounds":"novobiocin + phosphate => carbamoyl phosphate + descarbamoylnovobiocin"}
{"X":28765,"RHEA_ID":26111,"DIRECTION":"UN","MASTER_ID":26111,"ec":"4.2.1.115","compounds":"UDP-N-acetyl-alpha-D-glucosamine = H2O + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose"}
{"X":28766,"RHEA_ID":26112,"DIRECTION":"LR","MASTER_ID":26111,"metacyc":"RXN-9998","compounds":"UDP-N-acetyl-alpha-D-glucosamine => H2O + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose"}
{"X":28767,"RHEA_ID":26113,"compounds":"H2O + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose => UDP-N-acetyl-alpha-D-glucosamine"}
{"X":28768,"RHEA_ID":46587,"compounds":"1alpha-hydroxyvitamin D2 + O2 + reduced [NADPH--hemoprotein reductase] <=> 1alpha,25-dihydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":28769,"RHEA_ID":26115,"DIRECTION":"UN","MASTER_ID":26115,"ec":"4.2.3.39","compounds":"(2E,6E)-farnesyl diphosphate + H2O = diphosphate + epi-cedrol"}
{"X":28770,"RHEA_ID":26116,"DIRECTION":"LR","MASTER_ID":26115,"metacyc":"RXN-10004","compounds":"(2E,6E)-farnesyl diphosphate + H2O => diphosphate + epi-cedrol"}
{"X":28771,"RHEA_ID":26117,"compounds":"diphosphate + epi-cedrol => (2E,6E)-farnesyl diphosphate + H2O"}
{"X":28772,"RHEA_ID":36669,"compounds":"CoA + H(+) + N-(15Z-tetracosenoyl)-sphinganine => (15Z)-tetracosenoyl-CoA + sphinganine"}
{"X":28773,"RHEA_ID":26119,"DIRECTION":"UN","MASTER_ID":26119,"ec":"1.17.7.1","compounds":"(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":28774,"RHEA_ID":26120,"compounds":"(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":28775,"RHEA_ID":26121,"DIRECTION":"RL","MASTER_ID":26119,"metacyc":"RXN0-882","compounds":"2-C-methyl-D-erythritol 2,4-cyclic diphosphate + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":28776,"RHEA_ID":46595,"compounds":"alfacalcidol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> calcitriol + H2O + 2 oxidized [adrenodoxin]"}
{"X":28777,"RHEA_ID":26124,"compounds":"FAD + L-proline = (S)-1-pyrroline-5-carboxylate + FADH2"}
{"X":28778,"RHEA_ID":26125,"compounds":"FAD + L-proline => (S)-1-pyrroline-5-carboxylate + FADH2"}
{"X":28779,"RHEA_ID":26126,"compounds":"(S)-1-pyrroline-5-carboxylate + FADH2 => FAD + L-proline"}
{"X":28780,"RHEA_ID":26127,"DIRECTION":"BI","MASTER_ID":26124,"ecocyc":"RXN-821","metacyc":"RXN-821","compounds":"FAD + L-proline <=> (S)-1-pyrroline-5-carboxylate + FADH2"}
{"X":28781,"RHEA_ID":26128,"DIRECTION":"UN","MASTER_ID":26128,"ec":"4.2.3.44","compounds":"(+)-copalyl diphosphate = diphosphate + isopimara-7,15-diene"}
{"X":28782,"RHEA_ID":26129,"DIRECTION":"LR","MASTER_ID":26128,"metacyc":"RXN-8514","compounds":"(+)-copalyl diphosphate => diphosphate + isopimara-7,15-diene"}
{"X":28783,"RHEA_ID":26130,"compounds":"diphosphate + isopimara-7,15-diene => (+)-copalyl diphosphate"}
{"X":28784,"RHEA_ID":36681,"DIRECTION":"RL","MASTER_ID":36679,"metacyc":"RXN-15048","compounds":"dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADH => dTDP-6-deoxy-alpha-D-allose + NAD(+)"}
{"X":28785,"RHEA_ID":46604,"compounds":"[HPr protein]-O-phospho-L-serine + H(+) + phosphate = [HPr protein]-L-serine + diphosphate"}
{"X":28786,"RHEA_ID":26133,"compounds":"2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+)"}
{"X":28787,"RHEA_ID":26134,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+) => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O"}
{"X":28788,"RHEA_ID":26135,"compounds":"2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+)"}
{"X":28789,"RHEA_ID":26136,"DIRECTION":"UN","MASTER_ID":26136,"ec":"3.5.1.99","compounds":"H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + ethanolamine"}
{"X":28790,"RHEA_ID":26137,"DIRECTION":"LR","MASTER_ID":26136,"metacyc":"RXN6666-2","reactome":"R-HSA-5693751.1","compounds":"H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + ethanolamine"}
{"X":28791,"RHEA_ID":26137,"DIRECTION":"LR","MASTER_ID":26136,"metacyc":"RXN6666-2","reactome":"R-HSA-5693742.1","compounds":"H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + ethanolamine"}
{"X":28792,"RHEA_ID":26138,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + ethanolamine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine"}
{"X":28793,"RHEA_ID":46608,"DIRECTION":"UN","MASTER_ID":46608,"ec":"2.7.11.12","compounds":"ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]"}
{"X":28794,"RHEA_ID":26140,"compounds":"2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + H2O = 5-amino-6-(5-phospho-D-ribitylamino)uracil + NH4(+)"}
{"X":28795,"RHEA_ID":26141,"compounds":"2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + H2O => 5-amino-6-(5-phospho-D-ribitylamino)uracil + NH4(+)"}
{"X":28796,"RHEA_ID":26142,"compounds":"5-amino-6-(5-phospho-D-ribitylamino)uracil + NH4(+) => 2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + H2O"}
{"X":28797,"RHEA_ID":36694,"compounds":"octadecanoyl-CoA + sphing-4-enine <=> CoA + H(+) + N-octadecanoylsphing-4-enine"}
{"X":28798,"RHEA_ID":26144,"compounds":"2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + NADPH"}
{"X":28799,"RHEA_ID":26145,"compounds":"2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) => 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + NADPH"}
{"X":28800,"RHEA_ID":26146,"compounds":"2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + NADPH => 2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+)"}
{"X":28801,"RHEA_ID":26147,"compounds":"2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) <=> 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + NADPH"}
{"X":28802,"RHEA_ID":26148,"compounds":"2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + NADH"}
{"X":28803,"RHEA_ID":26149,"compounds":"2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) => 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + NADH"}
{"X":28804,"RHEA_ID":26150,"compounds":"2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + NADH => 2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+)"}
{"X":28805,"RHEA_ID":46614,"compounds":"cholesteryl (5Z,8Z,11Z,14Z,17Z-eicosapentaenoate) + CoA => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + cholesterol"}
{"X":28806,"RHEA_ID":26152,"DIRECTION":"UN","MASTER_ID":26152,"ec":"2.5.1.78","compounds":"(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate"}
{"X":28807,"RHEA_ID":26153,"compounds":"(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil => 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate"}
{"X":28808,"RHEA_ID":26154,"compounds":"6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate => (2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil"}
{"X":28809,"RHEA_ID":56649,"compounds":"3-oxochol-4-en-24-oyl-CoA + NAD(+) => 3-oxochol-4,6-dien-24-oyl-CoA + H(+) + NADH"}
{"X":28810,"RHEA_ID":26156,"compounds":"D-mannose + NADP(+) = D-glucosone + H(+) + NADPH"}
{"X":28811,"RHEA_ID":26157,"compounds":"D-mannose + NADP(+) => D-glucosone + H(+) + NADPH"}
{"X":28812,"RHEA_ID":26158,"compounds":"D-glucosone + H(+) + NADPH => D-mannose + NADP(+)"}
{"X":28813,"RHEA_ID":46622,"compounds":"cholesteryl (9Z,12Z,15Z)-octadecatrienoate + CoA => (9Z,12Z,15Z)-octadecatrienoyl-CoA + cholesterol"}
{"X":28814,"RHEA_ID":26160,"DIRECTION":"UN","MASTER_ID":26160,"ec":"5.4.99.31","compounds":"(S)-2,3-epoxysqualene = thalianol"}
{"X":28815,"RHEA_ID":26161,"DIRECTION":"LR","MASTER_ID":26160,"metacyc":"RXN-9630","compounds":"(S)-2,3-epoxysqualene => thalianol"}
{"X":28816,"RHEA_ID":26162,"compounds":"thalianol => (S)-2,3-epoxysqualene"}
{"X":28817,"RHEA_ID":46626,"compounds":"a L-5-monosubstituted hydantoin => a D-5-monosubstituted hydantoin"}
{"X":28818,"RHEA_ID":36715,"compounds":"sphinganine + tetracosenoyl-CoA = CoA + H(+) + N-tetracosenoylsphinganine"}
{"X":28819,"RHEA_ID":26165,"DIRECTION":"LR","MASTER_ID":26164,"metacyc":"RXN-18964","compounds":"AH2 + echinenone + O2 => 4'-hydroxyechinenone + A + H2O"}
{"X":28820,"RHEA_ID":26166,"compounds":"4'-hydroxyechinenone + A + H2O => AH2 + echinenone + O2"}
{"X":28821,"RHEA_ID":26167,"compounds":"AH2 + echinenone + O2 <=> 4'-hydroxyechinenone + A + H2O"}
{"X":28822,"RHEA_ID":36719,"compounds":"hexacosenoyl-CoA + sphinganine = CoA + H(+) + N-hexacosenoylsphinganine"}
{"X":28823,"RHEA_ID":26169,"DIRECTION":"LR","MASTER_ID":26168,"metacyc":"RXN-10445","compounds":"3-fumarylpyruvate + H2O => fumarate + H(+) + pyruvate"}
{"X":28824,"RHEA_ID":26170,"compounds":"fumarate + H(+) + pyruvate => 3-fumarylpyruvate + H2O"}
{"X":28825,"RHEA_ID":36722,"compounds":"hexacosenoyl-CoA + sphinganine <=> CoA + H(+) + N-hexacosenoylsphinganine"}
{"X":28826,"RHEA_ID":26172,"DIRECTION":"UN","MASTER_ID":26172,"ec":"2.3.1.189","compounds":"1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA = CoA + H(+) + mycothiol"}
{"X":28827,"RHEA_ID":26173,"DIRECTION":"LR","MASTER_ID":26172,"metacyc":"RXN1G-4","compounds":"1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA => CoA + H(+) + mycothiol"}
{"X":28828,"RHEA_ID":26174,"compounds":"CoA + H(+) + mycothiol => 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA"}
{"X":28829,"RHEA_ID":26175,"compounds":"1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA <=> CoA + H(+) + mycothiol"}
{"X":28830,"RHEA_ID":36731,"DIRECTION":"UN","MASTER_ID":36731,"ec":"1.3.1.102","compounds":"1-nitrocyclohexan + NADP(+) = 1-nitrocyclohexene + H(+) + NADPH"}
{"X":28831,"RHEA_ID":26177,"DIRECTION":"LR","MASTER_ID":26176,"metacyc":"RXN1G-121","compounds":"1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + ATP + L-cysteine => 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + H(+)"}
{"X":28832,"RHEA_ID":26178,"compounds":"1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + H(+) => 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + ATP + L-cysteine"}
{"X":28833,"RHEA_ID":26179,"compounds":"1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + ATP + L-cysteine <=> 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + H(+)"}
{"X":28834,"RHEA_ID":26180,"DIRECTION":"UN","MASTER_ID":26180,"ec":"3.5.1.103","compounds":"1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate"}
{"X":28835,"RHEA_ID":26181,"DIRECTION":"LR","MASTER_ID":26180,"metacyc":"RXN1G-2","compounds":"1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O => 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate"}
{"X":28836,"RHEA_ID":26182,"compounds":"1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate => 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O"}
{"X":28837,"RHEA_ID":36742,"compounds":"heptadecasphing-4-enine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoyl-heptadecasphingosine"}
{"X":28838,"RHEA_ID":36743,"compounds":"heptadecasphing-4-enine + tetracosenoyl-CoA = CoA + H(+) + N-tetracosenoyl-heptadecasphingosine"}
{"X":28839,"RHEA_ID":26185,"compounds":"1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H2O => 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + phosphate"}
{"X":28840,"RHEA_ID":26186,"compounds":"1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + phosphate => 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H2O"}
{"X":28841,"RHEA_ID":26187,"compounds":"1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H2O <=> 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + phosphate"}
{"X":28842,"RHEA_ID":26188,"DIRECTION":"UN","MASTER_ID":26188,"ec":"2.4.1.250","compounds":"1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine = 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H(+) + UDP"}
{"X":28843,"RHEA_ID":26189,"DIRECTION":"LR","MASTER_ID":26188,"metacyc":"RXN-6501","compounds":"1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine => 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H(+) + UDP"}
{"X":28844,"RHEA_ID":26190,"compounds":"1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H(+) + UDP => 1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":28845,"RHEA_ID":46654,"compounds":"5beta-dihydroepitestosterone + NADP(+) => epitestosterone + H(+) + NADPH"}
{"X":28846,"RHEA_ID":36751,"DIRECTION":"UN","MASTER_ID":36751,"ec":"2.4.1.304","compounds":"N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UDP-alpha-D-galactose = beta-D-Gal-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,octa-cis-undecaprenol + H(+) + UDP"}
{"X":28847,"RHEA_ID":26194,"compounds":"(S)-malate + ATP + CoA => (S)-malyl-CoA + ADP + phosphate"}
{"X":28848,"RHEA_ID":26195,"compounds":"(S)-malyl-CoA + ADP + phosphate => (S)-malate + ATP + CoA"}
{"X":28849,"RHEA_ID":46658,"compounds":"5beta-androstane-3,17-dione + NADP(+) => androst-4-ene-3,17-dione + H(+) + NADPH"}
{"X":28850,"RHEA_ID":36755,"DIRECTION":"UN","MASTER_ID":36755,"ec":"2.4.1.305","compounds":"N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UDP-alpha-D-glucose = beta-D-Glc-(1->3)-alpha-D-GlcNAc-diphospho-di-trans,octa-cis-undecaprenol + H(+) + UDP"}
{"X":28851,"RHEA_ID":26198,"DIRECTION":"LR","MASTER_ID":26197,"metacyc":"RXN-8015","compounds":"H2O + melamine => ammeline + NH4(+)"}
{"X":28852,"RHEA_ID":26199,"compounds":"ammeline + NH4(+) => H2O + melamine"}
{"X":28853,"RHEA_ID":46662,"compounds":"5beta-pregnan-3,20-dione + NADP(+) => H(+) + NADPH + progesterone"}
{"X":28854,"RHEA_ID":36759,"DIRECTION":"UN","MASTER_ID":36759,"ec":"2.4.1.306","compounds":"N-acetyl-alpha-D-galactosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UDP-N-acetyl-alpha-D-galactosamine = alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-di-trans,octa-cis-undecaprenol + H(+) + UDP"}
{"X":28855,"RHEA_ID":26202,"DIRECTION":"LR","MASTER_ID":26201,"metacyc":"RXN-8016","compounds":"ammeline + H(+) + H2O => ammelide + NH4(+)"}
{"X":28856,"RHEA_ID":26203,"compounds":"ammelide + NH4(+) => ammeline + H(+) + H2O"}
{"X":28857,"RHEA_ID":46666,"compounds":"5beta-dihydrocorticosterone + NADP(+) => corticosterone + H(+) + NADPH"}
{"X":28858,"RHEA_ID":26205,"DIRECTION":"UN","MASTER_ID":26205,"ec":"1.14.13.n7","compounds":"4-nitrophenol + H(+) + NADPH + O2 = 4-nitrocatechol + H2O + NADP(+)"}
{"X":28859,"RHEA_ID":26206,"DIRECTION":"LR","MASTER_ID":26205,"metacyc":"RXN-14162","compounds":"4-nitrophenol + H(+) + NADPH + O2 => 4-nitrocatechol + H2O + NADP(+)"}
{"X":28860,"RHEA_ID":26207,"compounds":"4-nitrocatechol + H2O + NADP(+) => 4-nitrophenol + H(+) + NADPH + O2"}
{"X":28861,"RHEA_ID":26208,"compounds":"4-nitrophenol + H(+) + NADPH + O2 <=> 4-nitrocatechol + H2O + NADP(+)"}
{"X":28862,"RHEA_ID":36767,"compounds":"2-hydroxytetracosenoyl-CoA + sphinganine = CoA + H(+) + N-(2-hydroxytetracosenoyl)-sphinganine"}
{"X":28863,"RHEA_ID":26209,"DIRECTION":"UN","MASTER_ID":26209,"ec":"4.1.2.49","compounds":"L-allo-threonine = acetaldehyde + glycine"}
{"X":28864,"RHEA_ID":26210,"DIRECTION":"LR","MASTER_ID":26209,"ecocyc":"LTAA-RXN","metacyc":"LTAA-RXN","compounds":"L-allo-threonine => acetaldehyde + glycine"}
{"X":28865,"RHEA_ID":26211,"compounds":"acetaldehyde + glycine => L-allo-threonine"}
{"X":28866,"RHEA_ID":36771,"DIRECTION":"UN","MASTER_ID":36771,"ec":"2.4.1.308","compounds":"beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-di-trans,octa-cis-undecaprenol + GDP-beta-L-fucose = alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)"}
{"X":28867,"RHEA_ID":26213,"DIRECTION":"UN","MASTER_ID":26213,"ec":"4.2.3.42","compounds":"9alpha-copalyl diphosphate + H2O = aphidicolan-16beta-ol + diphosphate"}
{"X":28868,"RHEA_ID":26214,"DIRECTION":"LR","MASTER_ID":26213,"metacyc":"RXN-10631","compounds":"9alpha-copalyl diphosphate + H2O => aphidicolan-16beta-ol + diphosphate"}
{"X":28869,"RHEA_ID":26215,"compounds":"aphidicolan-16beta-ol + diphosphate => 9alpha-copalyl diphosphate + H2O"}
{"X":28870,"RHEA_ID":46679,"compounds":"(4R)-hydroxy-(6R)-2,2,6-trimethylcyclohexanone + NAD(+) <=> (6R)-2,2,6-trimethyl-1,4-cyclohexanedione + H(+) + NADH"}
{"X":28871,"RHEA_ID":26217,"DIRECTION":"UN","MASTER_ID":26217,"ec":"1.14.14.144","compounds":"abieta-7,13-diene + O2 + reduced [NADPH--hemoprotein reductase] = abieta-7,13-dien-18-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":28872,"RHEA_ID":26218,"DIRECTION":"LR","MASTER_ID":26217,"metacyc":"RXN-8507","compounds":"abieta-7,13-diene + O2 + reduced [NADPH--hemoprotein reductase] => abieta-7,13-dien-18-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":28873,"RHEA_ID":26219,"compounds":"abieta-7,13-dien-18-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => abieta-7,13-diene + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":28874,"RHEA_ID":26221,"DIRECTION":"UN","MASTER_ID":26221,"ec":"1.14.14.145","compounds":"abieta-7,13-dien-18-ol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = abieta-7,13-dien-18-oate + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":28875,"RHEA_ID":26222,"DIRECTION":"LR","MASTER_ID":26221,"metacyc":"RXN-12799","compounds":"abieta-7,13-dien-18-ol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => abieta-7,13-dien-18-oate + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":28876,"RHEA_ID":26223,"compounds":"abieta-7,13-dien-18-oate + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => abieta-7,13-dien-18-ol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}
{"X":28877,"RHEA_ID":46687,"compounds":"3-oxochol-4-en-24-oyl-CoA + A <=> (22E)-3-oxo-chol-4,22-dien-24-oyl-CoA + AH2"}
{"X":28878,"RHEA_ID":26225,"DIRECTION":"UN","MASTER_ID":26225,"ec":"1.2.1.74","compounds":"abieta-7,13-dien-18-al + H2O + NAD(+) = abieta-7,13-dien-18-oate + 2 H(+) + NADH"}
{"X":28879,"RHEA_ID":26226,"DIRECTION":"LR","MASTER_ID":26225,"metacyc":"RXN-10624","compounds":"abieta-7,13-dien-18-al + H2O + NAD(+) => abieta-7,13-dien-18-oate + 2 H(+) + NADH"}
{"X":28880,"RHEA_ID":26227,"compounds":"abieta-7,13-dien-18-oate + 2 H(+) + NADH => abieta-7,13-dien-18-al + H2O + NAD(+)"}
{"X":28881,"RHEA_ID":46691,"compounds":"(25S)-3-oxocholest-4-en-26-oyl-CoA + A <=> 3-oxo-cholest-4,24-dien-26-oyl-CoA + AH2"}
{"X":28882,"RHEA_ID":26229,"DIRECTION":"UN","MASTER_ID":26229,"ec":"1.3.1.83","compounds":"3 NADP(+) + phytyl diphosphate = geranylgeranyl diphosphate + 3 H(+) + 3 NADPH"}
{"X":28883,"RHEA_ID":26230,"compounds":"3 NADP(+) + phytyl diphosphate => geranylgeranyl diphosphate + 3 H(+) + 3 NADPH"}
{"X":28884,"RHEA_ID":26231,"compounds":"geranylgeranyl diphosphate + 3 H(+) + 3 NADPH => 3 NADP(+) + phytyl diphosphate"}
{"X":28885,"RHEA_ID":36791,"DIRECTION":"UN","MASTER_ID":36791,"ec":"3.5.3.25","compounds":"H2O + N(omega)-hydroxy-L-arginine = hydroxyurea + L-ornithine"}
{"X":28886,"RHEA_ID":26233,"DIRECTION":"UN","MASTER_ID":26233,"ec":"1.14.14.146","compounds":"(2E,6E,10E)-geranylgeraniol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + plaunotol"}
{"X":28887,"RHEA_ID":26234,"DIRECTION":"LR","MASTER_ID":26233,"metacyc":"RXN-10626","compounds":"(2E,6E,10E)-geranylgeraniol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + plaunotol"}
{"X":28888,"RHEA_ID":26235,"compounds":"H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + plaunotol => (2E,6E,10E)-geranylgeraniol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":28889,"RHEA_ID":46699,"compounds":"a pseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine <=> an N(1)-methylpseudouridine in 16S/18S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":28890,"RHEA_ID":26237,"DIRECTION":"UN","MASTER_ID":26237,"ec":"3.1.7.5","compounds":"all-trans-geranylgeranyl diphosphate + H2O = (2E,6E,10E)-geranylgeraniol + diphosphate"}
{"X":28891,"RHEA_ID":26238,"DIRECTION":"LR","MASTER_ID":26237,"metacyc":"RXN-10627","compounds":"all-trans-geranylgeranyl diphosphate + H2O => (2E,6E,10E)-geranylgeraniol + diphosphate"}
{"X":28892,"RHEA_ID":26239,"compounds":"(2E,6E,10E)-geranylgeraniol + diphosphate => all-trans-geranylgeranyl diphosphate + H2O"}
{"X":28893,"RHEA_ID":46703,"compounds":"(R)-lipoate + GTP + H(+) <=> (R)-lipoyl-GMP + diphosphate"}
{"X":28894,"RHEA_ID":26241,"DIRECTION":"UN","MASTER_ID":26241,"ec":"4.2.3.41","compounds":"geranylgeranyl diphosphate = diphosphate + elisabethatriene"}
{"X":28895,"RHEA_ID":26242,"DIRECTION":"LR","MASTER_ID":26241,"metacyc":"RXN-10630","compounds":"geranylgeranyl diphosphate => diphosphate + elisabethatriene"}
{"X":28896,"RHEA_ID":26243,"compounds":"diphosphate + elisabethatriene => geranylgeranyl diphosphate"}
{"X":28897,"RHEA_ID":36803,"DIRECTION":"UN","MASTER_ID":36803,"ec":"4.2.1.105","compounds":"2-hydroxy-2,3-dihydrogenistein = genistein + H(+) + H2O"}
{"X":28898,"RHEA_ID":26245,"DIRECTION":"UN","MASTER_ID":26245,"ec":"4.2.3.43","compounds":"geranylgeranyl diphosphate = diphosphate + fusicocca-2,10(14)-diene"}
{"X":28899,"RHEA_ID":26246,"DIRECTION":"LR","MASTER_ID":26245,"metacyc":"RXN-10632","compounds":"geranylgeranyl diphosphate => diphosphate + fusicocca-2,10(14)-diene"}
{"X":28900,"RHEA_ID":46710,"compounds":"AMP + H(+) + salicyl-[ACP] => 2-hydroxybenzoyl-5'-AMP + holo-[ACP]"}
{"X":28901,"RHEA_ID":36807,"compounds":"H(+) + malonyl-CoA + octacosanoyl-CoA = 3-oxo-triacontanoyl-CoA + CO2 + CoA"}
{"X":28902,"RHEA_ID":26249,"compounds":"H(+) + levopimaradienol + NADPH + O2 = 2 H2O + levopimaradienal + NADP(+)"}
{"X":28903,"RHEA_ID":26250,"compounds":"H(+) + levopimaradienol + NADPH + O2 => 2 H2O + levopimaradienal + NADP(+)"}
{"X":28904,"RHEA_ID":26251,"compounds":"2 H2O + levopimaradienal + NADP(+) => H(+) + levopimaradienol + NADPH + O2"}
{"X":28905,"RHEA_ID":36811,"DIRECTION":"UN","MASTER_ID":36811,"ec":"2.3.1.227","compounds":"acetyl-CoA + GDP-alpha-D-perosamine = CoA + GDP-N-acetyl-alpha-D-perosamine + H(+)"}
{"X":28906,"RHEA_ID":26253,"compounds":"H(+) + isopimara-7,15-dienol + NADPH + O2 = 2 H2O + isopimara-7,15-dienal + NADP(+)"}
{"X":28907,"RHEA_ID":26254,"compounds":"H(+) + isopimara-7,15-dienol + NADPH + O2 => 2 H2O + isopimara-7,15-dienal + NADP(+)"}
{"X":28908,"RHEA_ID":26255,"compounds":"2 H2O + isopimara-7,15-dienal + NADP(+) => H(+) + isopimara-7,15-dienol + NADPH + O2"}
{"X":28909,"RHEA_ID":36815,"DIRECTION":"UN","MASTER_ID":36815,"ec":"5.4.99.59","compounds":"dTDP-alpha-D-fucose = dTDP-alpha-D-fucofuranose"}
{"X":28910,"RHEA_ID":26257,"compounds":"dehydroabietadienol + H(+) + NADPH + O2 = dehydroabietadienal + 2 H2O + NADP(+)"}
{"X":28911,"RHEA_ID":26258,"compounds":"dehydroabietadienol + H(+) + NADPH + O2 => dehydroabietadienal + 2 H2O + NADP(+)"}
{"X":28912,"RHEA_ID":26259,"compounds":"dehydroabietadienal + 2 H2O + NADP(+) => dehydroabietadienol + H(+) + NADPH + O2"}
{"X":28913,"RHEA_ID":36819,"compounds":"(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + CO2 + CoA"}
{"X":28914,"RHEA_ID":26261,"compounds":"H2O + isopimara-7,15-dienal + NADP(+) = 2 H(+) + isopimarate + NADPH"}
{"X":28915,"RHEA_ID":26262,"compounds":"H2O + isopimara-7,15-dienal + NADP(+) => 2 H(+) + isopimarate + NADPH"}
{"X":28916,"RHEA_ID":26263,"compounds":"2 H(+) + isopimarate + NADPH => H2O + isopimara-7,15-dienal + NADP(+)"}
{"X":28917,"RHEA_ID":36823,"DIRECTION":"UN","MASTER_ID":36823,"ec":"2.7.8.39","compounds":"1D-myo-inositol 3-phosphate + CDP-2,3-bis-(O-phytanyl)-sn-glycerol = CMP + H(+) + saturated 1-archaetidyl-1D-myo-inositol 3-phosphate"}
{"X":28918,"RHEA_ID":26265,"compounds":"dehydroabietadienal + H2O + NADP(+) = dehydroabietate + 2 H(+) + NADPH"}
{"X":28919,"RHEA_ID":26266,"compounds":"dehydroabietadienal + H2O + NADP(+) => dehydroabietate + 2 H(+) + NADPH"}
{"X":28920,"RHEA_ID":26267,"compounds":"dehydroabietate + 2 H(+) + NADPH => dehydroabietadienal + H2O + NADP(+)"}
{"X":28921,"RHEA_ID":36827,"DIRECTION":"UN","MASTER_ID":36827,"ec":"3.2.1.189","compounds":"dioscin + 3 H2O = D-glucose + diosgenin + 2 L-rhamnopyranose"}
{"X":28922,"RHEA_ID":26269,"DIRECTION":"UN","MASTER_ID":26269,"ec":"4.99.1.3","compounds":"Co-precorrin-2 + 3 H(+) = Co(2+) + precorrin-2"}
{"X":28923,"RHEA_ID":26270,"compounds":"Co-precorrin-2 + 3 H(+) => Co(2+) + precorrin-2"}
{"X":28924,"RHEA_ID":26271,"DIRECTION":"RL","MASTER_ID":26269,"metacyc":"RXN-8759","compounds":"Co(2+) + precorrin-2 => Co-precorrin-2 + 3 H(+)"}
{"X":28925,"RHEA_ID":36831,"DIRECTION":"UN","MASTER_ID":36831,"ec":"7.1.1.4","compounds":"2 caldariellaquinol + n H(+)(in) + O2 = 2 caldariellaquinone + n H(+)(out) + 2 H2O"}
{"X":28926,"RHEA_ID":26273,"compounds":"Co-precorrin-3 + S-adenosyl-L-methionine = Co-precorrin-4 + S-adenosyl-L-homocysteine"}
{"X":28927,"RHEA_ID":26274,"DIRECTION":"LR","MASTER_ID":26273,"metacyc":"RXN-8761","compounds":"Co-precorrin-3 + S-adenosyl-L-methionine => Co-precorrin-4 + S-adenosyl-L-homocysteine"}
{"X":28928,"RHEA_ID":26275,"compounds":"Co-precorrin-4 + S-adenosyl-L-homocysteine => Co-precorrin-3 + S-adenosyl-L-methionine"}
{"X":28929,"RHEA_ID":36835,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}
{"X":28930,"RHEA_ID":26277,"DIRECTION":"UN","MASTER_ID":26277,"ec":"2.1.1.271","compounds":"Co-precorrin-4 + S-adenosyl-L-methionine = Co-precorrin-5A + H(+) + S-adenosyl-L-homocysteine"}
{"X":28931,"RHEA_ID":26278,"DIRECTION":"LR","MASTER_ID":26277,"metacyc":"RXN-8762","compounds":"Co-precorrin-4 + S-adenosyl-L-methionine => Co-precorrin-5A + H(+) + S-adenosyl-L-homocysteine"}
{"X":28932,"RHEA_ID":26279,"compounds":"Co-precorrin-5A + H(+) + S-adenosyl-L-homocysteine => Co-precorrin-4 + S-adenosyl-L-methionine"}
{"X":28933,"RHEA_ID":36839,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}
{"X":28934,"RHEA_ID":26281,"DIRECTION":"UN","MASTER_ID":26281,"ec":"3.7.1.12","compounds":"Co-precorrin-5A + H2O = acetaldehyde + Co-precorrin-5B + H(+)"}
{"X":28935,"RHEA_ID":26282,"DIRECTION":"LR","MASTER_ID":26281,"metacyc":"RXN-8763","compounds":"Co-precorrin-5A + H2O => acetaldehyde + Co-precorrin-5B + H(+)"}
{"X":28936,"RHEA_ID":26283,"compounds":"acetaldehyde + Co-precorrin-5B + H(+) => Co-precorrin-5A + H2O"}
{"X":28937,"RHEA_ID":36843,"compounds":"(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + CO2 + CoA"}
{"X":28938,"RHEA_ID":26285,"DIRECTION":"UN","MASTER_ID":26285,"ec":"2.1.1.195","compounds":"Co-precorrin-5B + S-adenosyl-L-methionine = Co-precorrin-6A + S-adenosyl-L-homocysteine"}
{"X":28939,"RHEA_ID":26286,"DIRECTION":"LR","MASTER_ID":26285,"metacyc":"RXN-8764","compounds":"Co-precorrin-5B + S-adenosyl-L-methionine => Co-precorrin-6A + S-adenosyl-L-homocysteine"}
{"X":28940,"RHEA_ID":26287,"compounds":"Co-precorrin-6A + S-adenosyl-L-homocysteine => Co-precorrin-5B + S-adenosyl-L-methionine"}
{"X":28941,"RHEA_ID":26289,"DIRECTION":"UN","MASTER_ID":26289,"ec":"6.3.5.11","compounds":"2 ATP + cob(II)yrinate + 2 H2O + 2 L-glutamine = 2 ADP + cob(II)yrinate a,c diamide + 2 H(+) + 2 L-glutamate + 2 phosphate"}
{"X":28942,"RHEA_ID":26290,"DIRECTION":"LR","MASTER_ID":26289,"metacyc":"RXN-8769","compounds":"2 ATP + cob(II)yrinate + 2 H2O + 2 L-glutamine => 2 ADP + cob(II)yrinate a,c diamide + 2 H(+) + 2 L-glutamate + 2 phosphate"}
{"X":28943,"RHEA_ID":26291,"compounds":"2 ADP + cob(II)yrinate a,c diamide + 2 H(+) + 2 L-glutamate + 2 phosphate => 2 ATP + cob(II)yrinate + 2 H2O + 2 L-glutamine"}
{"X":28944,"RHEA_ID":56786,"compounds":"(6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate => (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n + (n-1) H2O"}
{"X":28945,"RHEA_ID":26293,"compounds":"(1'S,5'S)-averufin + NADPH + O2 = 1'-hydroxyversicolorone + H2O + NADP(+)"}
{"X":28946,"RHEA_ID":26294,"DIRECTION":"LR","MASTER_ID":26293,"metacyc":"RXN-9486","compounds":"(1'S,5'S)-averufin + NADPH + O2 => 1'-hydroxyversicolorone + H2O + NADP(+)"}
{"X":28947,"RHEA_ID":26295,"compounds":"1'-hydroxyversicolorone + H2O + NADP(+) => (1'S,5'S)-averufin + NADPH + O2"}
{"X":28948,"RHEA_ID":26296,"compounds":"(1'S,5'S)-averufin + NADPH + O2 <=> 1'-hydroxyversicolorone + H2O + NADP(+)"}
{"X":28949,"RHEA_ID":26297,"DIRECTION":"UN","MASTER_ID":26297,"ec":"2.8.1.10","compounds":"1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O"}
{"X":28950,"RHEA_ID":26298,"DIRECTION":"LR","MASTER_ID":26297,"metacyc":"THIAZOLSYN2-RXN","compounds":"1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH => 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O"}
{"X":28951,"RHEA_ID":26299,"compounds":"2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O => 1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH"}
{"X":28952,"RHEA_ID":56794,"compounds":"2 [corrinoid adenosyltransferase]-cob(I)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] => 2 cob(II)alamin--[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein]"}
{"X":28953,"RHEA_ID":26301,"DIRECTION":"UN","MASTER_ID":26301,"ec":"4.1.1.97","compounds":"5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+) = (S)-allantoin + CO2"}
{"X":28954,"RHEA_ID":26302,"DIRECTION":"LR","MASTER_ID":26301,"metacyc":"RXN-6201","compounds":"5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+) => (S)-allantoin + CO2"}
{"X":28955,"RHEA_ID":26303,"compounds":"(S)-allantoin + CO2 => 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)"}
{"X":28956,"RHEA_ID":46767,"compounds":"a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-acyl-2-[(3E)-hexadec-3-enoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":28957,"RHEA_ID":26305,"DIRECTION":"UN","MASTER_ID":26305,"ec":"1.13.11.74","compounds":"2-aminophenol + O2 = 2-aminomuconate 6-semialdehyde"}
{"X":28958,"RHEA_ID":26306,"DIRECTION":"LR","MASTER_ID":26305,"metacyc":"RXN-8818","compounds":"2-aminophenol + O2 => 2-aminomuconate 6-semialdehyde"}
{"X":28959,"RHEA_ID":26307,"compounds":"2-aminomuconate 6-semialdehyde => 2-aminophenol + O2"}
{"X":28960,"RHEA_ID":46770,"compounds":"a 1-acyl-2-[(9Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":28961,"RHEA_ID":26309,"DIRECTION":"UN","MASTER_ID":26309,"ec":"3.1.2.28","compounds":"1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA + H(+)"}
{"X":28962,"RHEA_ID":26310,"DIRECTION":"LR","MASTER_ID":26309,"ecocyc":"RXN-9311","metacyc":"RXN-9311","compounds":"1,4-dihydroxy-2-naphthoyl-CoA + H2O => 1,4-dihydroxy-2-naphthoate + CoA + H(+)"}
{"X":28963,"RHEA_ID":26311,"compounds":"1,4-dihydroxy-2-naphthoate + CoA + H(+) => 1,4-dihydroxy-2-naphthoyl-CoA + H2O"}
{"X":28964,"RHEA_ID":46774,"compounds":"a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 1-octadecanoyl 2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":28965,"RHEA_ID":26313,"DIRECTION":"UN","MASTER_ID":26313,"ec":"4.1.2.56","compounds":"2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate = dihydroxyacetone phosphate + L-aspartate 4-semialdehyde"}
{"X":28966,"RHEA_ID":26314,"compounds":"2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate => dihydroxyacetone phosphate + L-aspartate 4-semialdehyde"}
{"X":28967,"RHEA_ID":26315,"DIRECTION":"RL","MASTER_ID":26313,"metacyc":"RXN-13865","compounds":"dihydroxyacetone phosphate + L-aspartate 4-semialdehyde => 2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate"}
{"X":28968,"RHEA_ID":36874,"compounds":"(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + CO2 + CoA"}
{"X":28969,"RHEA_ID":26317,"DIRECTION":"UN","MASTER_ID":26317,"ec":"4.1.99.20","compounds":"2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate = 3-amino-4-hydroxybenzoate + H(+) + 2 H2O + phosphate"}
{"X":28970,"RHEA_ID":26318,"DIRECTION":"LR","MASTER_ID":26317,"metacyc":"RXN-13866","compounds":"2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate => 3-amino-4-hydroxybenzoate + H(+) + 2 H2O + phosphate"}
{"X":28971,"RHEA_ID":26319,"compounds":"3-amino-4-hydroxybenzoate + H(+) + 2 H2O + phosphate => 2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate"}
{"X":28972,"RHEA_ID":46782,"compounds":"a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":28973,"RHEA_ID":26321,"DIRECTION":"UN","MASTER_ID":26321,"ec":"2.1.1.n1","compounds":"resorcinol + S-adenosyl-L-methionine = 3-methoxyphenol + H(+) + S-adenosyl-L-homocysteine"}
{"X":28974,"RHEA_ID":26322,"DIRECTION":"LR","MASTER_ID":26321,"metacyc":"RXN-14163","compounds":"resorcinol + S-adenosyl-L-methionine => 3-methoxyphenol + H(+) + S-adenosyl-L-homocysteine"}
{"X":28975,"RHEA_ID":26323,"compounds":"3-methoxyphenol + H(+) + S-adenosyl-L-homocysteine => resorcinol + S-adenosyl-L-methionine"}
{"X":28976,"RHEA_ID":36882,"compounds":"(8Z,11Z,14Z)-eicosatrienoyl-CoA + AH2 + O2 <=> (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + A + 2 H2O"}
{"X":28977,"RHEA_ID":26325,"DIRECTION":"UN","MASTER_ID":26325,"ec":"2.1.1.n7","compounds":"(8Z,11Z)-5-(pentadeca-8,11,14-trien-1-yl)resorcinol + S-adenosyl-L-methionine = (8Z,11Z)-5-(pentadeca- 8,11,14-trien-1-yl)resorcinol-3-methyl ether + H(+) + S-adenosyl-L-homocysteine"}
{"X":28978,"RHEA_ID":26326,"DIRECTION":"LR","MASTER_ID":26325,"metacyc":"RXN-9619","compounds":"(8Z,11Z)-5-(pentadeca-8,11,14-trien-1-yl)resorcinol + S-adenosyl-L-methionine => (8Z,11Z)-5-(pentadeca- 8,11,14-trien-1-yl)resorcinol-3-methyl ether + H(+) + S-adenosyl-L-homocysteine"}
{"X":28979,"RHEA_ID":26327,"compounds":"(8Z,11Z)-5-(pentadeca- 8,11,14-trien-1-yl)resorcinol-3-methyl ether + H(+) + S-adenosyl-L-homocysteine => (8Z,11Z)-5-(pentadeca-8,11,14-trien-1-yl)resorcinol + S-adenosyl-L-methionine"}
{"X":28980,"RHEA_ID":36886,"compounds":"(8Z,11Z,14Z)-eicosatrienoyl-CoA + AH2 + O2 <=> (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + A + 2 H2O"}
{"X":28981,"RHEA_ID":26329,"DIRECTION":"UN","MASTER_ID":26329,"ec":"2.6.1.105","compounds":"8-amino-7-oxononanoate + L-lysine = (S)-2-amino-6-oxohexanoate + 7,8-diaminononanoate"}
{"X":28982,"RHEA_ID":26330,"compounds":"8-amino-7-oxononanoate + L-lysine => (S)-2-amino-6-oxohexanoate + 7,8-diaminononanoate"}
{"X":28983,"RHEA_ID":26331,"compounds":"(S)-2-amino-6-oxohexanoate + 7,8-diaminononanoate => 8-amino-7-oxononanoate + L-lysine"}
{"X":28984,"RHEA_ID":46794,"compounds":"2 [Fe(III)-cytochrome b5] + an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 H2O => 2 [Fe(II)-cytochrome b5] + an (11Z,14Z)-icosadienoyl-containing glycerolipid + 2 H(+) + O2"}
{"X":28985,"RHEA_ID":26333,"DIRECTION":"UN","MASTER_ID":26333,"ec":"2.8.1.12","compounds":"2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + cyclic pyranopterin phosphate + H2O = 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 4 H(+) + molybdopterin"}
{"X":28986,"RHEA_ID":26334,"DIRECTION":"LR","MASTER_ID":26333,"ecocyc":"RXN-8342","metacyc":"RXN-8342","compounds":"2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + cyclic pyranopterin phosphate + H2O => 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 4 H(+) + molybdopterin"}
{"X":28987,"RHEA_ID":26335,"compounds":"2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 4 H(+) + molybdopterin => 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + cyclic pyranopterin phosphate + H2O"}
{"X":28988,"RHEA_ID":36894,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + AH2 + O2 <=> (9Z,12Z,15Z)-octadecatrienoyl-CoA + A + 2 H2O"}
{"X":28989,"RHEA_ID":26337,"DIRECTION":"UN","MASTER_ID":26337,"ec":"2.1.1.10","compounds":"L-homocysteine + S-methyl-L-methionine = H(+) + 2 L-methionine"}
{"X":28990,"RHEA_ID":26338,"DIRECTION":"LR","MASTER_ID":26337,"ecocyc":"MMUM-RXN","metacyc":"MMUM-RXN","compounds":"L-homocysteine + S-methyl-L-methionine => H(+) + 2 L-methionine"}
{"X":28991,"RHEA_ID":26339,"compounds":"H(+) + 2 L-methionine => L-homocysteine + S-methyl-L-methionine"}
{"X":28992,"RHEA_ID":46802,"compounds":"Na(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin] => H(+) + Na(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":28993,"RHEA_ID":26341,"DIRECTION":"UN","MASTER_ID":26341,"ec":"2.1.1.280","compounds":"L-selenocysteine + S-methyl-L-methionine = H(+) + L-methionine + Se-methyl-L-selenocysteine"}
{"X":28994,"RHEA_ID":26342,"DIRECTION":"LR","MASTER_ID":26341,"metacyc":"RXN-11061","compounds":"L-selenocysteine + S-methyl-L-methionine => H(+) + L-methionine + Se-methyl-L-selenocysteine"}
{"X":28995,"RHEA_ID":26343,"compounds":"H(+) + L-methionine + Se-methyl-L-selenocysteine => L-selenocysteine + S-methyl-L-methionine"}
{"X":28996,"RHEA_ID":56838,"compounds":"5'-deoxyadenosine + E-Y cross-linked-[PQQ precursor protein] + H(+) + L-methionine => [PQQ precursor protein] + S-adenosyl-L-methionine"}
{"X":28997,"RHEA_ID":26345,"DIRECTION":"UN","MASTER_ID":26345,"ec":"1.1.1.365","compounds":"L-galactonate + NADP(+) = aldehydo-D-galacturonate + H(+) + NADPH"}
{"X":28998,"RHEA_ID":26346,"compounds":"L-galactonate + NADP(+) => aldehydo-D-galacturonate + H(+) + NADPH"}
{"X":28999,"RHEA_ID":26347,"compounds":"aldehydo-D-galacturonate + H(+) + NADPH => L-galactonate + NADP(+)"}
{"X":29000,"RHEA_ID":56842,"compounds":"(2Z,4E)-4-amino-6-oxohepta-2,4-dienedioate + H(+) => 5-amino-2-hydroxybenzoate + O2"}
{"X":29001,"RHEA_ID":26349,"DIRECTION":"UN","MASTER_ID":26349,"ec":"3.1.3.93","compounds":"beta-L-galactose 1-phosphate + H2O = L-galactose + phosphate"}
{"X":29002,"RHEA_ID":26350,"DIRECTION":"LR","MASTER_ID":26349,"metacyc":"RXNQT-4142","compounds":"beta-L-galactose 1-phosphate + H2O => L-galactose + phosphate"}
{"X":29003,"RHEA_ID":26351,"compounds":"L-galactose + phosphate => beta-L-galactose 1-phosphate + H2O"}
{"X":29004,"RHEA_ID":46814,"compounds":"4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+) => 4,4-dimethyl-8,14-cholestadien-3beta-ol + H(+) + NADPH"}
{"X":29005,"RHEA_ID":26361,"DIRECTION":"UN","MASTER_ID":26361,"ec":"4.1.99.19","compounds":"L-tyrosine + NADPH + S-adenosyl-L-methionine = 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP(+)"}
{"X":29006,"RHEA_ID":26362,"DIRECTION":"LR","MASTER_ID":26361,"ecocyc":"RXN-11319","metacyc":"RXN-11319","compounds":"L-tyrosine + NADPH + S-adenosyl-L-methionine => 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP(+)"}
{"X":29007,"RHEA_ID":26363,"compounds":"2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP(+) => L-tyrosine + NADPH + S-adenosyl-L-methionine"}
{"X":29008,"RHEA_ID":36914,"compounds":"(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + CO2 + CoA"}
{"X":29009,"RHEA_ID":26373,"DIRECTION":"UN","MASTER_ID":26373,"ec":"1.11.1.20","compounds":"[thioredoxin]-disulfide + prostamide F2alpha = [thioredoxin]-dithiol + prostamide H2"}
{"X":29010,"RHEA_ID":26374,"compounds":"[thioredoxin]-disulfide + prostamide F2alpha => [thioredoxin]-dithiol + prostamide H2"}
{"X":29011,"RHEA_ID":26375,"compounds":"[thioredoxin]-dithiol + prostamide H2 => [thioredoxin]-disulfide + prostamide F2alpha"}
{"X":29012,"RHEA_ID":36918,"compounds":"(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + CO2 + CoA"}
{"X":29013,"RHEA_ID":26377,"compounds":"GTP = cyclic pyranopterin phosphate + diphosphate"}
{"X":29014,"RHEA_ID":26378,"DIRECTION":"LR","MASTER_ID":26377,"metacyc":"RXN-8340","compounds":"GTP => cyclic pyranopterin phosphate + diphosphate"}
{"X":29015,"RHEA_ID":26379,"compounds":"cyclic pyranopterin phosphate + diphosphate => GTP"}
{"X":29016,"RHEA_ID":26380,"compounds":"GTP <=> cyclic pyranopterin phosphate + diphosphate"}
{"X":29017,"RHEA_ID":26381,"DIRECTION":"UN","MASTER_ID":26381,"ec":"1.1.1.n11","compounds":"4-hydroxybutanoate + NADP(+) = H(+) + NADPH + succinate semialdehyde"}
{"X":29018,"RHEA_ID":26382,"compounds":"4-hydroxybutanoate + NADP(+) => H(+) + NADPH + succinate semialdehyde"}
{"X":29019,"RHEA_ID":26383,"DIRECTION":"RL","MASTER_ID":26381,"metacyc":"RXN-11002","compounds":"H(+) + NADPH + succinate semialdehyde => 4-hydroxybutanoate + NADP(+)"}
{"X":29020,"RHEA_ID":36926,"compounds":"(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + CO2 + CoA"}
{"X":29021,"RHEA_ID":26385,"DIRECTION":"UN","MASTER_ID":26385,"ec":"1.13.11.75","compounds":"all-trans-8'-apo-beta-carotenal + O2 = (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + all-trans-retinal"}
{"X":29022,"RHEA_ID":26386,"DIRECTION":"LR","MASTER_ID":26385,"metacyc":"RXN-11783","compounds":"all-trans-8'-apo-beta-carotenal + O2 => (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + all-trans-retinal"}
{"X":29023,"RHEA_ID":26387,"compounds":"(2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + all-trans-retinal => all-trans-8'-apo-beta-carotenal + O2"}
{"X":29024,"RHEA_ID":46834,"compounds":"4alpha-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+) => 4alpha-methyl-5alpha-cholest-8-en-3-one + H(+) + NADPH"}
{"X":29025,"RHEA_ID":26389,"DIRECTION":"UN","MASTER_ID":26389,"ec":"1.13.11.71","compounds":"all-trans-beta-carotene + O2 = all-trans-10'-apo-beta-carotenal + beta-ionone"}
{"X":29026,"RHEA_ID":26390,"DIRECTION":"LR","MASTER_ID":26389,"metacyc":"RXN-10741","reactome":"R-HSA-5164399.1","compounds":"all-trans-beta-carotene + O2 => all-trans-10'-apo-beta-carotenal + beta-ionone"}
{"X":29027,"RHEA_ID":26391,"compounds":"all-trans-10'-apo-beta-carotenal + beta-ionone => all-trans-beta-carotene + O2"}
{"X":29028,"RHEA_ID":46838,"compounds":"4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O => 4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}
{"X":29029,"RHEA_ID":26393,"DIRECTION":"UN","MASTER_ID":26393,"ec":"1.14.99.n4","compounds":"all-trans-zeaxanthin + 2 O2 = 2 (3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial"}
{"X":29030,"RHEA_ID":26394,"DIRECTION":"LR","MASTER_ID":26393,"metacyc":"RXN-7885","compounds":"all-trans-zeaxanthin + 2 O2 => 2 (3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial"}
{"X":29031,"RHEA_ID":26395,"compounds":"2 (3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial => all-trans-zeaxanthin + 2 O2"}
{"X":29032,"RHEA_ID":26396,"compounds":"all-trans-zeaxanthin + 2 O2 <=> 2 (3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial"}
{"X":29033,"RHEA_ID":26397,"DIRECTION":"UN","MASTER_ID":26397,"ec":"1.13.11.84","compounds":"all-trans-zeaxanthin + 2 O2 = 2 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde"}
{"X":29034,"RHEA_ID":26398,"DIRECTION":"LR","MASTER_ID":26397,"metacyc":"RXN-8469","compounds":"all-trans-zeaxanthin + 2 O2 => 2 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde"}
{"X":29035,"RHEA_ID":26399,"compounds":"2 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde => all-trans-zeaxanthin + 2 O2"}
{"X":29036,"RHEA_ID":36942,"compounds":"AH2 + O2 + tetradecanoyl-CoA <=> (9Z)-tetradecenoyl-CoA + A + 2 H2O"}
{"X":29037,"RHEA_ID":26401,"DIRECTION":"UN","MASTER_ID":26401,"ec":"1.13.11.70","compounds":"all-trans-10'-apo-beta-carotenal + O2 = (2E,4E,6E)-4-methylocta-2,4,6-trienedial + 13-apo-beta-carotenone"}
{"X":29038,"RHEA_ID":26402,"DIRECTION":"LR","MASTER_ID":26401,"metacyc":"RXN-12393","compounds":"all-trans-10'-apo-beta-carotenal + O2 => (2E,4E,6E)-4-methylocta-2,4,6-trienedial + 13-apo-beta-carotenone"}
{"X":29039,"RHEA_ID":26403,"compounds":"(2E,4E,6E)-4-methylocta-2,4,6-trienedial + 13-apo-beta-carotenone => all-trans-10'-apo-beta-carotenal + O2"}
{"X":29040,"RHEA_ID":46850,"compounds":"5alpha-cholest-8-en-3-one + CO2 + NADPH => 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NADP(+)"}
{"X":29041,"RHEA_ID":26405,"compounds":"aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH4(+) = H(+) + 4 H2O + phosphate + pyridoxal 5'-phosphate"}
{"X":29042,"RHEA_ID":26406,"DIRECTION":"LR","MASTER_ID":26405,"metacyc":"RXN-12590","compounds":"aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH4(+) => H(+) + 4 H2O + phosphate + pyridoxal 5'-phosphate"}
{"X":29043,"RHEA_ID":26407,"compounds":"H(+) + 4 H2O + phosphate + pyridoxal 5'-phosphate => aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH4(+)"}
{"X":29044,"RHEA_ID":46854,"compounds":"5alpha-cholest-8-en-3beta-ol + NADP(+) => 5alpha-cholest-8-en-3-one + H(+) + NADPH"}
{"X":29045,"RHEA_ID":26410,"DIRECTION":"UN","MASTER_ID":26410,"ec":"4.2.1.126","compounds":"H2O + N-acetyl-D-muramate 6-phosphate = (R)-lactate + N-acetyl-D-glucosamine 6-phosphate"}
{"X":29046,"RHEA_ID":26411,"compounds":"H2O + N-acetyl-D-muramate 6-phosphate => (R)-lactate + N-acetyl-D-glucosamine 6-phosphate"}
{"X":29047,"RHEA_ID":26412,"compounds":"(R)-lactate + N-acetyl-D-glucosamine 6-phosphate => H2O + N-acetyl-D-muramate 6-phosphate"}
{"X":29048,"RHEA_ID":46858,"compounds":"4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+) => 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADPH"}
{"X":29049,"RHEA_ID":26414,"DIRECTION":"UN","MASTER_ID":26414,"ec":"1.4.3.4","compounds":"a secondary aliphatic amine + H2O + O2 = a primary amine + an aldehyde + H2O2"}
{"X":29050,"RHEA_ID":26415,"DIRECTION":"LR","MASTER_ID":26414,"metacyc":"RXN-9598","compounds":"a secondary aliphatic amine + H2O + O2 => a primary amine + an aldehyde + H2O2"}
{"X":29051,"RHEA_ID":26416,"compounds":"a primary amine + an aldehyde + H2O2 => a secondary aliphatic amine + H2O + O2"}
{"X":29052,"RHEA_ID":36958,"compounds":"AH2 + O2 + pentadecanoyl-CoA <=> (9Z)-pentadecenoyl-CoA + A + 2 H2O"}
{"X":29053,"RHEA_ID":26418,"compounds":"(3R)-3-hydroxy-8'-apo-beta-carotenal + O2 = (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + (3R)-all-trans-3-hydroxyretinal"}
{"X":29054,"RHEA_ID":26419,"compounds":"(3R)-3-hydroxy-8'-apo-beta-carotenal + O2 => (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + (3R)-all-trans-3-hydroxyretinal"}
{"X":29055,"RHEA_ID":26420,"compounds":"(2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + (3R)-all-trans-3-hydroxyretinal => (3R)-3-hydroxy-8'-apo-beta-carotenal + O2"}
{"X":29056,"RHEA_ID":26421,"compounds":"(3R)-3-hydroxy-8'-apo-beta-carotenal + O2 <=> (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + (3R)-all-trans-3-hydroxyretinal"}
{"X":29057,"RHEA_ID":26422,"DIRECTION":"UN","MASTER_ID":26422,"ec":"2.8.2.n2","compounds":"3'-phosphoadenylyl sulfate + thyroxine = adenosine 3',5'-bisphosphate + H(+) + thyroxine sulfate"}
{"X":29058,"RHEA_ID":26423,"DIRECTION":"LR","MASTER_ID":26422,"metacyc":"RXN-10614","compounds":"3'-phosphoadenylyl sulfate + thyroxine => adenosine 3',5'-bisphosphate + H(+) + thyroxine sulfate"}
{"X":29059,"RHEA_ID":26424,"compounds":"adenosine 3',5'-bisphosphate + H(+) + thyroxine sulfate => 3'-phosphoadenylyl sulfate + thyroxine"}
{"X":29060,"RHEA_ID":26425,"compounds":"3'-phosphoadenylyl sulfate + thyroxine <=> adenosine 3',5'-bisphosphate + H(+) + thyroxine sulfate"}
{"X":29061,"RHEA_ID":26426,"DIRECTION":"UN","MASTER_ID":26426,"ec":"6.3.4.2","compounds":"ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate"}
{"X":29062,"RHEA_ID":26427,"DIRECTION":"LR","MASTER_ID":26426,"ecocyc":"CTPSYN-RXN","metacyc":"CTPSYN-RXN","reactome":"R-HSA-73647.3","compounds":"ATP + H2O + L-glutamine + UTP => ADP + CTP + 2 H(+) + L-glutamate + phosphate"}
{"X":29063,"RHEA_ID":26427,"DIRECTION":"LR","MASTER_ID":26426,"ecocyc":"CTPSYN-RXN","metacyc":"CTPSYN-RXN","reactome":"R-HSA-504054.3","compounds":"ATP + H2O + L-glutamine + UTP => ADP + CTP + 2 H(+) + L-glutamate + phosphate"}
{"X":29064,"RHEA_ID":36970,"compounds":"(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + CO2 + CoA"}
{"X":29065,"RHEA_ID":36971,"DIRECTION":"UN","MASTER_ID":36971,"ec":"5.1.3.27","compounds":"dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-allose"}
{"X":29066,"RHEA_ID":26430,"DIRECTION":"UN","MASTER_ID":26430,"ec":"4.2.3.45","compounds":"(+)-copalyl diphosphate + H2O = diphosphate + phyllocladan-16alpha-ol"}
{"X":29067,"RHEA_ID":26431,"DIRECTION":"LR","MASTER_ID":26430,"metacyc":"RXN-10775","compounds":"(+)-copalyl diphosphate + H2O => diphosphate + phyllocladan-16alpha-ol"}
{"X":29068,"RHEA_ID":46882,"compounds":"3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":29069,"RHEA_ID":36975,"DIRECTION":"UN","MASTER_ID":36975,"ec":"2.4.2.57","compounds":"AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate"}
{"X":29070,"RHEA_ID":26434,"DIRECTION":"UN","MASTER_ID":26434,"ec":"4.2.1.122","compounds":"indole + L-serine = H2O + L-tryptophan"}
{"X":29071,"RHEA_ID":26435,"DIRECTION":"LR","MASTER_ID":26434,"ecocyc":"RXN0-2382","metacyc":"RXN0-2382","compounds":"indole + L-serine => H2O + L-tryptophan"}
{"X":29072,"RHEA_ID":26436,"compounds":"H2O + L-tryptophan => indole + L-serine"}
{"X":29073,"RHEA_ID":36979,"compounds":"(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + CO2 + CoA"}
{"X":29074,"RHEA_ID":26438,"DIRECTION":"UN","MASTER_ID":26438,"ec":"1.1.1.298","compounds":"3-hydroxypropanoate + NADP(+) = 3-oxopropanoate + H(+) + NADPH"}
{"X":29075,"RHEA_ID":26439,"compounds":"3-hydroxypropanoate + NADP(+) => 3-oxopropanoate + H(+) + NADPH"}
{"X":29076,"RHEA_ID":36982,"compounds":"(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + CO2 + CoA"}
{"X":29077,"RHEA_ID":26441,"compounds":"3-hydroxypropanoate + NADP(+) <=> 3-oxopropanoate + H(+) + NADPH"}
{"X":29078,"RHEA_ID":26442,"DIRECTION":"UN","MASTER_ID":26442,"ec":"1.1.5.5","compounds":"a ubiquinone + ethanol = a ubiquinol + acetaldehyde"}
{"X":29079,"RHEA_ID":26443,"compounds":"a ubiquinone + ethanol => a ubiquinol + acetaldehyde"}
{"X":29080,"RHEA_ID":36986,"compounds":"(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + CO2 + CoA"}
{"X":29081,"RHEA_ID":26446,"DIRECTION":"UN","MASTER_ID":26446,"ec":"1.2.1.75","compounds":"3-oxopropanoate + CoA + NADP(+) = H(+) + malonyl-CoA + NADPH"}
{"X":29082,"RHEA_ID":26447,"compounds":"3-oxopropanoate + CoA + NADP(+) => H(+) + malonyl-CoA + NADPH"}
{"X":29083,"RHEA_ID":36990,"compounds":"CMP + phosphate <=> alpha-D-ribose 1,5-bisphosphate + cytosine"}
{"X":29084,"RHEA_ID":36991,"DIRECTION":"UN","MASTER_ID":36991,"ec":"2.4.2.57","compounds":"phosphate + UMP = alpha-D-ribose 1,5-bisphosphate + uracil"}
{"X":29085,"RHEA_ID":26450,"DIRECTION":"UN","MASTER_ID":26450,"ec":"1.2.1.76","compounds":"CoA + NADP(+) + succinate semialdehyde = H(+) + NADPH + succinyl-CoA"}
{"X":29086,"RHEA_ID":26451,"compounds":"CoA + NADP(+) + succinate semialdehyde => H(+) + NADPH + succinyl-CoA"}
{"X":29087,"RHEA_ID":36994,"compounds":"phosphate + UMP <=> alpha-D-ribose 1,5-bisphosphate + uracil"}
{"X":29088,"RHEA_ID":36995,"compounds":"(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + CO2 + CoA"}
{"X":29089,"RHEA_ID":26454,"DIRECTION":"UN","MASTER_ID":26454,"ec":"1.3.1.84","compounds":"NADP(+) + propanoyl-CoA = acryloyl-CoA + H(+) + NADPH"}
{"X":29090,"RHEA_ID":26455,"compounds":"NADP(+) + propanoyl-CoA => acryloyl-CoA + H(+) + NADPH"}
{"X":29091,"RHEA_ID":36998,"compounds":"(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + CO2 + CoA"}
{"X":29092,"RHEA_ID":26457,"compounds":"NADP(+) + propanoyl-CoA <=> acryloyl-CoA + H(+) + NADPH"}
{"X":29093,"RHEA_ID":26458,"compounds":"ethylnitronate + FMNH2 + O2 = acetaldehyde + FMN + 2 H(+) + H2O + nitrite"}
{"X":29094,"RHEA_ID":26459,"compounds":"ethylnitronate + FMNH2 + O2 => acetaldehyde + FMN + 2 H(+) + H2O + nitrite"}
{"X":29095,"RHEA_ID":37002,"compounds":"(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":29096,"RHEA_ID":37003,"compounds":"(11Z,14Z,17Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(13Z,16Z,19Z)-docosatrienoyl-CoA + CO2 + CoA"}
{"X":29097,"RHEA_ID":26462,"DIRECTION":"UN","MASTER_ID":26462,"ec":"2.1.1.163","compounds":"6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + S-adenosyl-L-methionine = 3-methyl-6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + H(+) + S-adenosyl-L-homocysteine"}
{"X":29098,"RHEA_ID":26463,"compounds":"6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + S-adenosyl-L-methionine => 3-methyl-6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + H(+) + S-adenosyl-L-homocysteine"}
{"X":29099,"RHEA_ID":37006,"compounds":"(11Z,14Z,17Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(13Z,16Z,19Z)-docosatrienoyl-CoA + CO2 + CoA"}
{"X":29100,"RHEA_ID":26465,"compounds":"6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + S-adenosyl-L-methionine <=> 3-methyl-6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + H(+) + S-adenosyl-L-homocysteine"}
{"X":29101,"RHEA_ID":26466,"DIRECTION":"UN","MASTER_ID":26466,"ec":"2.1.1.163","compounds":"a 2-demethylmenaquinone + S-adenosyl-L-methionine = a menaquinone + H(+) + S-adenosyl-L-homocysteine"}
{"X":29102,"RHEA_ID":26467,"compounds":"a 2-demethylmenaquinone + S-adenosyl-L-methionine => a menaquinone + H(+) + S-adenosyl-L-homocysteine"}
{"X":29103,"RHEA_ID":26468,"compounds":"a menaquinone + H(+) + S-adenosyl-L-homocysteine => a 2-demethylmenaquinone + S-adenosyl-L-methionine"}
{"X":29104,"RHEA_ID":26470,"DIRECTION":"UN","MASTER_ID":26470,"ec":"2.3.1.188","compounds":"(E)-feruloyl-CoA + 16-hydroxyhexadecanoate = 16-feruloyloxyhexadecanoate + CoA"}
{"X":29105,"RHEA_ID":26471,"compounds":"(E)-feruloyl-CoA + 16-hydroxyhexadecanoate => 16-feruloyloxyhexadecanoate + CoA"}
{"X":29106,"RHEA_ID":26472,"compounds":"16-feruloyloxyhexadecanoate + CoA => (E)-feruloyl-CoA + 16-hydroxyhexadecanoate"}
{"X":29107,"RHEA_ID":37015,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) = a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}
{"X":29108,"RHEA_ID":26474,"DIRECTION":"UN","MASTER_ID":26474,"ec":"2.4.1.247","compounds":"beta-D-galactosyl-(1->4)-L-rhamnose + phosphate = alpha-D-galactose 1-phosphate + L-rhamnopyranose"}
{"X":29109,"RHEA_ID":26475,"compounds":"beta-D-galactosyl-(1->4)-L-rhamnose + phosphate => alpha-D-galactose 1-phosphate + L-rhamnopyranose"}
{"X":29110,"RHEA_ID":26476,"compounds":"alpha-D-galactose 1-phosphate + L-rhamnopyranose => beta-D-galactosyl-(1->4)-L-rhamnose + phosphate"}
{"X":29111,"RHEA_ID":37019,"compounds":"A + D-serine + H2O = 3-hydroxypyruvate + AH2 + NH4(+)"}
{"X":29112,"RHEA_ID":26478,"DIRECTION":"UN","MASTER_ID":26478,"ec":"2.5.1.74","compounds":"1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+) = a 2-demethylmenaquinol + CO2 + diphosphate"}
{"X":29113,"RHEA_ID":26479,"compounds":"1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+) => a 2-demethylmenaquinol + CO2 + diphosphate"}
{"X":29114,"RHEA_ID":26480,"compounds":"a 2-demethylmenaquinol + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+)"}
{"X":29115,"RHEA_ID":26482,"DIRECTION":"UN","MASTER_ID":26482,"ec":"2.5.1.75","compounds":"adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA"}
{"X":29116,"RHEA_ID":26483,"compounds":"adenosine(37) in tRNA + dimethylallyl diphosphate => diphosphate + N(6)-dimethylallyladenosine(37) in tRNA"}
{"X":29117,"RHEA_ID":26484,"compounds":"diphosphate + N(6)-dimethylallyladenosine(37) in tRNA => adenosine(37) in tRNA + dimethylallyl diphosphate"}
{"X":29118,"RHEA_ID":26486,"DIRECTION":"UN","MASTER_ID":26486,"ec":"2.5.1.76","compounds":"H(+) + O-phospho-L-serine + sulfite = L-cysteate + phosphate"}
{"X":29119,"RHEA_ID":37033,"compounds":"2-dehydro-3-deoxy-D-arabinonate + H2O => D-ribonate"}
{"X":29120,"RHEA_ID":26488,"compounds":"L-cysteate + phosphate => H(+) + O-phospho-L-serine + sulfite"}
{"X":29121,"RHEA_ID":26489,"compounds":"H(+) + O-phospho-L-serine + sulfite <=> L-cysteate + phosphate"}
{"X":29122,"RHEA_ID":26490,"DIRECTION":"UN","MASTER_ID":26490,"ec":"1.7.3.1","compounds":"a secondary nitroalkane + H2O + O2 = a ketone + H(+) + H2O2 + nitrite"}
{"X":29123,"RHEA_ID":37037,"compounds":"2-oxopentanoate + H(+) + NADH + NH4(+) => H2O + L-2-aminopentanoate + NAD(+)"}
{"X":29124,"RHEA_ID":26492,"compounds":"a ketone + H(+) + H2O2 + nitrite => a secondary nitroalkane + H2O + O2"}
{"X":29125,"RHEA_ID":26494,"DIRECTION":"UN","MASTER_ID":26494,"ec":"1.14.19.9","compounds":"chloride + FADH2 + L-tryptophan + O2 = 7-chloro-L-tryptophan + FAD + 2 H2O"}
{"X":29126,"RHEA_ID":37041,"compounds":"5 A + delta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O => 5 AH2 + 2 H(+) + heme b + 4 O2"}
{"X":29127,"RHEA_ID":26496,"compounds":"7-chloro-L-tryptophan + FAD + 2 H2O => chloride + FADH2 + L-tryptophan + O2"}
{"X":29128,"RHEA_ID":37043,"compounds":"ATP + H2O + L-alanyl-L-glutamate(out) = ADP + H(+) + L-alanyl-L-glutamate(in) + phosphate"}
{"X":29129,"RHEA_ID":26498,"compounds":"delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + UDP-alpha-D-glucose = delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP"}
{"X":29130,"RHEA_ID":37045,"compounds":"ADP + H(+) + L-alanyl-L-glutamate(in) + phosphate => ATP + H2O + L-alanyl-L-glutamate(out)"}
{"X":29131,"RHEA_ID":26500,"compounds":"delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP => delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + UDP-alpha-D-glucose"}
{"X":29132,"RHEA_ID":37047,"compounds":"H(+)(out) + L-histidine(out) = H(+)(in) + L-histidine(in)"}
{"X":29133,"RHEA_ID":26502,"compounds":"delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP-alpha-D-glucose = 2 H(+) + ternatin C5 + UDP"}
{"X":29134,"RHEA_ID":37049,"compounds":"H(+)(in) + L-histidine(in) => H(+)(out) + L-histidine(out)"}
{"X":29135,"RHEA_ID":26504,"compounds":"2 H(+) + ternatin C5 + UDP => delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP-alpha-D-glucose"}
{"X":29136,"RHEA_ID":37051,"DIRECTION":"UN","MASTER_ID":37051,"ec":"1.3.7.15","compounds":"3-deacetyl-3-vinylbacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate = ATP + chlorophyllide a + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":29137,"RHEA_ID":26506,"DIRECTION":"UN","MASTER_ID":26506,"ec":"3.5.1.99","compounds":"(9Z)-octadecenamide + H2O = (9Z)-octadecenoate + NH4(+)"}
{"X":29138,"RHEA_ID":37053,"DIRECTION":"RL","MASTER_ID":37051,"metacyc":"RXN-8792","compounds":"ATP + chlorophyllide a + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin] => 3-deacetyl-3-vinylbacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate"}
{"X":29139,"RHEA_ID":26508,"compounds":"(9Z)-octadecenoate + NH4(+) => (9Z)-octadecenamide + H2O"}
{"X":29140,"RHEA_ID":37055,"DIRECTION":"UN","MASTER_ID":37055,"ec":"2.5.1.111","compounds":"3-(4-hydroxyphenyl)pyruvate + dimethylallyl diphosphate = 3-dimethylallyl-4-hydroxyphenylpyruvate + diphosphate"}
{"X":29141,"RHEA_ID":26510,"DIRECTION":"UN","MASTER_ID":26510,"ec":"3.5.1.101","compounds":"H2O + L-prolinamide = L-proline + NH4(+)"}
{"X":29142,"RHEA_ID":26511,"compounds":"H2O + L-prolinamide => L-proline + NH4(+)"}
{"X":29143,"RHEA_ID":26512,"compounds":"L-proline + NH4(+) => H2O + L-prolinamide"}
{"X":29144,"RHEA_ID":37059,"DIRECTION":"UN","MASTER_ID":37059,"ec":"2.3.1.234","compounds":"adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA"}
{"X":29145,"RHEA_ID":26514,"DIRECTION":"UN","MASTER_ID":26514,"ec":"3.7.1.11","compounds":"cyclohexan-1,2-dione + H2O = 6-oxohexanoate + H(+)"}
{"X":29146,"RHEA_ID":37061,"compounds":"AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA => adenosine(37) in tRNA + L-threonylcarbamoyladenylate"}
{"X":29147,"RHEA_ID":26516,"compounds":"6-oxohexanoate + H(+) => cyclohexan-1,2-dione + H2O"}
{"X":29148,"RHEA_ID":37063,"compounds":"2-sulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":29149,"RHEA_ID":26518,"DIRECTION":"UN","MASTER_ID":26518,"ec":"4.2.1.116","compounds":"3-hydroxypropanoyl-CoA = acryloyl-CoA + H2O"}
{"X":29150,"RHEA_ID":37065,"compounds":"2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine => 2-sulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine"}
{"X":29151,"RHEA_ID":26520,"DIRECTION":"RL","MASTER_ID":26518,"metacyc":"RXN-6383","compounds":"acryloyl-CoA + H2O => 3-hydroxypropanoyl-CoA"}
{"X":29152,"RHEA_ID":37067,"DIRECTION":"UN","MASTER_ID":37067,"ec":"2.8.4.3","compounds":"[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine"}
{"X":29153,"RHEA_ID":26522,"DIRECTION":"UN","MASTER_ID":26522,"ec":"4.2.1.117","compounds":"(2S,3S)-2-methylcitrate = 2-methyl-trans-aconitate + H2O"}
{"X":29154,"RHEA_ID":37069,"compounds":"2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine => [sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine"}
{"X":29155,"RHEA_ID":26524,"compounds":"2-methyl-trans-aconitate + H2O => (2S,3S)-2-methylcitrate"}
{"X":29156,"RHEA_ID":26525,"compounds":"(2S,3S)-2-methylcitrate <=> 2-methyl-trans-aconitate + H2O"}
{"X":29157,"RHEA_ID":26526,"DIRECTION":"UN","MASTER_ID":26526,"ec":"4.2.1.119","compounds":"a (3R)-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O"}
{"X":29158,"RHEA_ID":37073,"compounds":"2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine => [sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine"}
{"X":29159,"RHEA_ID":26528,"compounds":"a (2E)-enoyl-CoA + H2O => a (3R)-hydroxyacyl-CoA"}
{"X":29160,"RHEA_ID":26530,"DIRECTION":"UN","MASTER_ID":26530,"ec":"4.2.1.120","compounds":"4-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O"}
{"X":29161,"RHEA_ID":37077,"compounds":"2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine => [sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine"}
{"X":29162,"RHEA_ID":26532,"compounds":"(2E)-butenoyl-CoA + H2O => 4-hydroxybutanoyl-CoA"}
{"X":29163,"RHEA_ID":37079,"compounds":"2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":29164,"RHEA_ID":26534,"DIRECTION":"UN","MASTER_ID":26534,"ec":"6.2.1.36","compounds":"3-hydroxypropanoate + ATP + CoA = 3-hydroxypropanoyl-CoA + AMP + diphosphate"}
{"X":29165,"RHEA_ID":37081,"compounds":"2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine => 2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine"}
{"X":29166,"RHEA_ID":26536,"compounds":"3-hydroxypropanoyl-CoA + AMP + diphosphate => 3-hydroxypropanoate + ATP + CoA"}
{"X":29167,"RHEA_ID":37083,"DIRECTION":"UN","MASTER_ID":37083,"ec":"2.8.4.4","compounds":"[sulfur carrier]-SH + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + S-adenosyl-L-methionine = [sulfur carrier]-H + H(+) + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-homocysteine"}
{"X":29168,"RHEA_ID":26538,"compounds":"hydrogencarbonate + NH4(+) + phosphate = carbamoyl phosphate + 2 H2O"}
{"X":29169,"RHEA_ID":26539,"compounds":"hydrogencarbonate + NH4(+) + phosphate => carbamoyl phosphate + 2 H2O"}
{"X":29170,"RHEA_ID":26540,"compounds":"carbamoyl phosphate + 2 H2O => hydrogencarbonate + NH4(+) + phosphate"}
{"X":29171,"RHEA_ID":26541,"compounds":"hydrogencarbonate + NH4(+) + phosphate <=> carbamoyl phosphate + 2 H2O"}
{"X":29172,"RHEA_ID":26542,"DIRECTION":"UN","MASTER_ID":26542,"ec":"3.5.1.100","compounds":"(R)-piperazine-2-carboxamide + H2O = (R)-piperazine-2-carboxylate + NH4(+)"}
{"X":29173,"RHEA_ID":37089,"compounds":"3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine => [sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine"}
{"X":29174,"RHEA_ID":26544,"compounds":"(R)-piperazine-2-carboxylate + NH4(+) => (R)-piperazine-2-carboxamide + H2O"}
{"X":29175,"RHEA_ID":37091,"compounds":"(8Z,11Z,14Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(10Z,13Z,16Z)-docosatrienoyl-CoA + CO2 + CoA"}
{"X":29176,"RHEA_ID":26546,"DIRECTION":"UN","MASTER_ID":26546,"ec":"3.5.1.100","compounds":"beta-alaninamide + H2O = beta-alanine + NH4(+)"}
{"X":29177,"RHEA_ID":37093,"compounds":"3-oxo-(10Z,13Z,16Z)-docosatrienoyl-CoA + CO2 + CoA => (8Z,11Z,14Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA"}
{"X":29178,"RHEA_ID":26548,"compounds":"beta-alanine + NH4(+) => beta-alaninamide + H2O"}
{"X":29179,"RHEA_ID":26550,"DIRECTION":"UN","MASTER_ID":26550,"ec":"3.5.1.101","compounds":"(S)-piperazine-2-carboxamide + H2O = (S)-piperazine-2-carboxylate + NH4(+)"}
{"X":29180,"RHEA_ID":37097,"compounds":"3-oxo-(12Z,15Z,18Z,21Z)-tetracosatetraenoyl-CoA + CO2 + CoA => (10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA"}
{"X":29181,"RHEA_ID":26552,"compounds":"(S)-piperazine-2-carboxylate + NH4(+) => (S)-piperazine-2-carboxamide + H2O"}
{"X":29182,"RHEA_ID":37099,"DIRECTION":"UN","MASTER_ID":37099,"ec":"3.6.1.59","compounds":"a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + H2O = 7-methyl-GMP + a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+)"}
{"X":29183,"RHEA_ID":26554,"DIRECTION":"UN","MASTER_ID":26554,"ec":"3.4.17.23","compounds":"angiotensin II + H2O = angiotensin-(1-7) + L-phenylalanine"}
{"X":29184,"RHEA_ID":37101,"compounds":"7-methyl-GMP + a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + H2O"}
{"X":29185,"RHEA_ID":26556,"compounds":"angiotensin-(1-7) + L-phenylalanine => angiotensin II + H2O"}
{"X":29186,"RHEA_ID":26557,"compounds":"angiotensin II + H2O <=> angiotensin-(1-7) + L-phenylalanine"}
{"X":29187,"RHEA_ID":26558,"DIRECTION":"UN","MASTER_ID":26558,"ec":"4.2.1.116","compounds":"(3S)-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O"}
{"X":29188,"RHEA_ID":37105,"compounds":"(N(2),N(2),N(7))-trimethylguanosine 5'-phosphate + a 5'-diphospho end in mRNA + 2 H(+) => a 5'-(N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine) in mRNA + H2O"}
{"X":29189,"RHEA_ID":26560,"DIRECTION":"RL","MASTER_ID":26558,"reactome":"R-HSA-77314.2","compounds":"(2E)-butenoyl-CoA + H2O => (3S)-hydroxybutanoyl-CoA"}
{"X":29190,"RHEA_ID":37107,"DIRECTION":"UN","MASTER_ID":37107,"ec":"3.1.3.91","compounds":"7-methyl-GMP + H2O = N(7)-methylguanosine + phosphate"}
{"X":29191,"RHEA_ID":26562,"DIRECTION":"UN","MASTER_ID":26562,"ec":"4.1.3.36","compounds":"2-succinylbenzoyl-CoA + H(+) = 1,4-dihydroxy-2-naphthoyl-CoA + H2O"}
{"X":29192,"RHEA_ID":37109,"compounds":"N(7)-methylguanosine + phosphate => 7-methyl-GMP + H2O"}
{"X":29193,"RHEA_ID":26564,"compounds":"1,4-dihydroxy-2-naphthoyl-CoA + H2O => 2-succinylbenzoyl-CoA + H(+)"}
{"X":29194,"RHEA_ID":37111,"compounds":"(15Z)-tetracosenoyl-CoA + sphing-4-enine = CoA + H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine"}
{"X":29195,"RHEA_ID":27270,"DIRECTION":"UN","MASTER_ID":27270,"ec":"1.2.1.n2","compounds":"CoA + hexadecanal + NADP(+) = H(+) + hexadecanoyl-CoA + NADPH"}
{"X":29196,"RHEA_ID":37113,"compounds":"CoA + H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine => (15Z)-tetracosenoyl-CoA + sphing-4-enine"}
{"X":29197,"RHEA_ID":27272,"compounds":"H(+) + hexadecanoyl-CoA + NADPH => CoA + hexadecanal + NADP(+)"}
{"X":29198,"RHEA_ID":27273,"compounds":"CoA + hexadecanal + NADP(+) <=> H(+) + hexadecanoyl-CoA + NADPH"}
{"X":29199,"RHEA_ID":27274,"DIRECTION":"UN","MASTER_ID":27274,"ec":"1.1.1.302","compounds":"2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADH"}
{"X":29200,"RHEA_ID":27275,"compounds":"2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) => 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADH"}
{"X":29201,"RHEA_ID":27276,"DIRECTION":"RL","MASTER_ID":27274,"metacyc":"RXN-10057","compounds":"2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADH => 2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+)"}
{"X":29202,"RHEA_ID":37119,"DIRECTION":"UN","MASTER_ID":37119,"ec":"2.3.1.231","compounds":"7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + CO2 + S-adenosyl-L-methionine = 2 H(+) + S-adenosyl-L-homocysteine + wybutosine(37) in tRNA(Phe)"}
{"X":29203,"RHEA_ID":27278,"DIRECTION":"UN","MASTER_ID":27278,"ec":"1.1.1.302","compounds":"2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADPH"}
{"X":29204,"RHEA_ID":37121,"compounds":"2 H(+) + S-adenosyl-L-homocysteine + wybutosine(37) in tRNA(Phe) => 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + CO2 + S-adenosyl-L-methionine"}
{"X":29205,"RHEA_ID":27280,"DIRECTION":"RL","MASTER_ID":27278,"metacyc":"RXN-10057","compounds":"2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADPH => 2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+)"}
{"X":29206,"RHEA_ID":37123,"compounds":"sphing-4-enine + tetracosenoyl-CoA = CoA + H(+) + N-(tetracosenoyl)-sphing-4-enine"}
{"X":29207,"RHEA_ID":27282,"DIRECTION":"UN","MASTER_ID":27282,"ec":"3.5.1.102","compounds":"2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H(+)"}
{"X":29208,"RHEA_ID":27283,"DIRECTION":"LR","MASTER_ID":27282,"metacyc":"RXN-10056","compounds":"2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O => 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H(+)"}
{"X":29209,"RHEA_ID":27284,"compounds":"2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H(+) => 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O"}
{"X":29210,"RHEA_ID":27285,"compounds":"2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O <=> 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H(+)"}
{"X":29211,"RHEA_ID":27286,"DIRECTION":"UN","MASTER_ID":27286,"ec":"1.1.1.304","compounds":"(S)-acetoin + NAD(+) = diacetyl + H(+) + NADH"}
{"X":29212,"RHEA_ID":37129,"compounds":"CO2 + H(+) + phosphonate + succinate => 2-oxoglutarate + dioxidophosphate + H2O2"}
{"X":29213,"RHEA_ID":27288,"DIRECTION":"RL","MASTER_ID":27286,"metacyc":"RXN-11032","compounds":"diacetyl + H(+) + NADH => (S)-acetoin + NAD(+)"}
{"X":29214,"RHEA_ID":27290,"DIRECTION":"UN","MASTER_ID":27290,"ec":"1.17.99.7","compounds":"A + formate + H(+) = AH2 + CO2"}
{"X":29215,"RHEA_ID":37133,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate"}
{"X":29216,"RHEA_ID":27292,"compounds":"AH2 + CO2 => A + formate + H(+)"}
{"X":29217,"RHEA_ID":27293,"compounds":"A + formate + H(+) <=> AH2 + CO2"}
{"X":29218,"RHEA_ID":27294,"DIRECTION":"UN","MASTER_ID":27294,"ec":"1.1.98.2","compounds":"D-glucose 6-phosphate + H(+) + oxidized coenzyme F420-(gamma-Glu)(n) = 6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420-(gamma-Glu)(n)"}
{"X":29219,"RHEA_ID":37137,"compounds":"1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate"}
{"X":29220,"RHEA_ID":27296,"compounds":"6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420-(gamma-Glu)(n) => D-glucose 6-phosphate + H(+) + oxidized coenzyme F420-(gamma-Glu)(n)"}
{"X":29221,"RHEA_ID":37139,"compounds":"(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycero-3-phosphate = 1-(9Z,12Z,15Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}
{"X":29222,"RHEA_ID":27298,"DIRECTION":"UN","MASTER_ID":27298,"ec":"1.2.1.78","compounds":"2-formylbenzoate + H2O + NAD(+) = 2 H(+) + NADH + phthalate"}
{"X":29223,"RHEA_ID":37141,"compounds":"1-(9Z,12Z,15Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycero-3-phosphate"}
{"X":29224,"RHEA_ID":27300,"compounds":"2 H(+) + NADH + phthalate => 2-formylbenzoate + H2O + NAD(+)"}
{"X":29225,"RHEA_ID":37143,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":29226,"RHEA_ID":27302,"DIRECTION":"UN","MASTER_ID":27302,"ec":"1.4.3.23","compounds":"7-chloro-L-tryptophan + O2 = 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2"}
{"X":29227,"RHEA_ID":27303,"DIRECTION":"LR","MASTER_ID":27302,"metacyc":"RXN-10843","compounds":"7-chloro-L-tryptophan + O2 => 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2"}
{"X":29228,"RHEA_ID":27304,"compounds":"3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 => 7-chloro-L-tryptophan + O2"}
{"X":29229,"RHEA_ID":37147,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":29230,"RHEA_ID":27306,"DIRECTION":"UN","MASTER_ID":27306,"ec":"1.5.99.13","compounds":"A + D-proline = 1-pyrroline-2-carboxylate + AH2"}
{"X":29231,"RHEA_ID":27307,"compounds":"A + D-proline => 1-pyrroline-2-carboxylate + AH2"}
{"X":29232,"RHEA_ID":27308,"compounds":"1-pyrroline-2-carboxylate + AH2 => A + D-proline"}
{"X":29233,"RHEA_ID":37151,"compounds":"(9Z)-octadecenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate = 1-heptadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}
{"X":29234,"RHEA_ID":27310,"DIRECTION":"UN","MASTER_ID":27310,"ec":"1.13.11.56","compounds":"naphthalene-1,2-diol + O2 = 2-hydroxychromene-2-carboxylate + H(+)"}
{"X":29235,"RHEA_ID":37153,"compounds":"1-heptadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate"}
{"X":29236,"RHEA_ID":27312,"compounds":"2-hydroxychromene-2-carboxylate + H(+) => naphthalene-1,2-diol + O2"}
{"X":29237,"RHEA_ID":37155,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + heptadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":29238,"RHEA_ID":27314,"DIRECTION":"UN","MASTER_ID":27314,"ec":"1.13.12.17","compounds":"dichlorochromopyrrolate + 6 H(+) + 4 NADH + 4 O2 = 2 CO2 + dichloroarcyriaflavin A + 6 H2O + 4 NAD(+)"}
{"X":29239,"RHEA_ID":37157,"compounds":"1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + heptadecanoyl-CoA"}
{"X":29240,"RHEA_ID":27316,"compounds":"2 CO2 + dichloroarcyriaflavin A + 6 H2O + 4 NAD(+) => dichlorochromopyrrolate + 6 H(+) + 4 NADH + 4 O2"}
{"X":29241,"RHEA_ID":37159,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA"}
{"X":29242,"RHEA_ID":27318,"compounds":"uracil(in) = uracil(out)"}
{"X":29243,"RHEA_ID":37161,"compounds":"1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate"}
{"X":29244,"RHEA_ID":27320,"compounds":"uracil(in) <=> uracil(out)"}
{"X":29245,"RHEA_ID":27321,"DIRECTION":"UN","MASTER_ID":27321,"ec":"1.14.14.147","compounds":"3-epi-6-deoxocathasterone + O2 + reduced [NADPH--hemoprotein reductase] = 6-deoxotyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":29246,"RHEA_ID":27322,"DIRECTION":"LR","MASTER_ID":27321,"metacyc":"RXN-11052","compounds":"3-epi-6-deoxocathasterone + O2 + reduced [NADPH--hemoprotein reductase] => 6-deoxotyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":29247,"RHEA_ID":37165,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate"}
{"X":29248,"RHEA_ID":37166,"compounds":"(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":29249,"RHEA_ID":27325,"DIRECTION":"UN","MASTER_ID":27325,"ec":"1.14.14.147","compounds":"(22S,24R)-22-hydroxy-5alpha-ergostan-3-one + O2 + reduced [NADPH--hemoprotein reductase] = 3-dehydro-6-deoxoteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":29250,"RHEA_ID":27326,"DIRECTION":"LR","MASTER_ID":27325,"metacyc":"RXN-11101","compounds":"(22S,24R)-22-hydroxy-5alpha-ergostan-3-one + O2 + reduced [NADPH--hemoprotein reductase] => 3-dehydro-6-deoxoteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":29251,"RHEA_ID":37169,"compounds":"(2E,6E)-farnesal + H(+) + NADH => (2E,6E)-farnesol + NAD(+)"}
{"X":29252,"RHEA_ID":47086,"compounds":"3-(4-hydroxyphenyl)pyruvate + L-methionine => 4-methylsulfanyl-2-oxobutanoate + L-tyrosine"}
{"X":29253,"RHEA_ID":27329,"DIRECTION":"UN","MASTER_ID":27329,"ec":"1.14.13.113","compounds":"H(+) + NADH + O2 + urate = 5-hydroxyisourate + H2O + NAD(+)"}
{"X":29254,"RHEA_ID":27330,"DIRECTION":"LR","MASTER_ID":27329,"metacyc":"RXN-11186","compounds":"H(+) + NADH + O2 + urate => 5-hydroxyisourate + H2O + NAD(+)"}
{"X":29255,"RHEA_ID":37173,"compounds":"1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA"}
{"X":29256,"RHEA_ID":37174,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":29257,"RHEA_ID":27333,"DIRECTION":"UN","MASTER_ID":27333,"ec":"1.14.13.114","compounds":"6-hydroxynicotinate + 2 H(+) + NADH + O2 = 2,5-dihydroxypyridine + CO2 + H2O + NAD(+)"}
{"X":29258,"RHEA_ID":27334,"DIRECTION":"LR","MASTER_ID":27333,"metacyc":"RXN-7573","compounds":"6-hydroxynicotinate + 2 H(+) + NADH + O2 => 2,5-dihydroxypyridine + CO2 + H2O + NAD(+)"}
{"X":29259,"RHEA_ID":27335,"compounds":"2,5-dihydroxypyridine + CO2 + H2O + NAD(+) => 6-hydroxynicotinate + 2 H(+) + NADH + O2"}
{"X":29260,"RHEA_ID":37178,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + pentadecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-pentadecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":29261,"RHEA_ID":27337,"DIRECTION":"UN","MASTER_ID":27337,"ec":"1.14.15.8","compounds":"2 H(+) + O2 + progesterone + reduced 2[4Fe-4S]-[ferredoxin] = 15beta-hydroxyprogesterone + H2O + oxidized 2[4Fe-4S]-[ferredoxin]"}
{"X":29262,"RHEA_ID":27338,"DIRECTION":"LR","MASTER_ID":27337,"metacyc":"RXN-11240","compounds":"2 H(+) + O2 + progesterone + reduced 2[4Fe-4S]-[ferredoxin] => 15beta-hydroxyprogesterone + H2O + oxidized 2[4Fe-4S]-[ferredoxin]"}
{"X":29263,"RHEA_ID":27339,"compounds":"15beta-hydroxyprogesterone + H2O + oxidized 2[4Fe-4S]-[ferredoxin] => 2 H(+) + O2 + progesterone + reduced 2[4Fe-4S]-[ferredoxin]"}
{"X":29264,"RHEA_ID":37182,"compounds":"(9Z)-octadecenoyl-CoA + 1-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphate <=> (6Z,9Z,12Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}
{"X":29265,"RHEA_ID":27341,"DIRECTION":"UN","MASTER_ID":27341,"ec":"1.14.99.39","compounds":"AH2 + NH4(+) + O2 = A + H(+) + H2O + hydroxylamine"}
{"X":29266,"RHEA_ID":27342,"DIRECTION":"LR","MASTER_ID":27341,"metacyc":"AMONITRO-RXN","compounds":"AH2 + NH4(+) + O2 => A + H(+) + H2O + hydroxylamine"}
{"X":29267,"RHEA_ID":37185,"compounds":"1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphate"}
{"X":29268,"RHEA_ID":27345,"DIRECTION":"UN","MASTER_ID":27345,"ec":"1.13.11.79","compounds":"FMNH2 + O2 = 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialurate + H(+)"}
{"X":29269,"RHEA_ID":27346,"DIRECTION":"LR","MASTER_ID":27345,"metacyc":"RXN-8771","compounds":"FMNH2 + O2 => 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialurate + H(+)"}
{"X":29270,"RHEA_ID":27347,"compounds":"5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialurate + H(+) => FMNH2 + O2"}
{"X":29271,"RHEA_ID":37190,"compounds":"(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycerol 3-phosphate <=> 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}
{"X":29272,"RHEA_ID":27349,"DIRECTION":"UN","MASTER_ID":27349,"ec":"2.8.4.2","compounds":"arsenate + mycothiol = arseno-mycothiol + H2O"}
{"X":29273,"RHEA_ID":27350,"DIRECTION":"LR","MASTER_ID":27349,"metacyc":"RXN-11187","compounds":"arsenate + mycothiol => arseno-mycothiol + H2O"}
{"X":29274,"RHEA_ID":27351,"compounds":"arseno-mycothiol + H2O => arsenate + mycothiol"}
{"X":29275,"RHEA_ID":37194,"compounds":"2',3'-cyclic AMP + H2O <=> adenosine 2'-phosphate + H(+)"}
{"X":29276,"RHEA_ID":27353,"DIRECTION":"UN","MASTER_ID":27353,"ec":"2.1.1.164","compounds":"4'-demethylrebeccamycin + S-adenosyl-L-methionine = H(+) + rebeccamycin + S-adenosyl-L-homocysteine"}
{"X":29277,"RHEA_ID":27354,"DIRECTION":"LR","MASTER_ID":27353,"metacyc":"RXN-10847","compounds":"4'-demethylrebeccamycin + S-adenosyl-L-methionine => H(+) + rebeccamycin + S-adenosyl-L-homocysteine"}
{"X":29278,"RHEA_ID":27355,"compounds":"H(+) + rebeccamycin + S-adenosyl-L-homocysteine => 4'-demethylrebeccamycin + S-adenosyl-L-methionine"}
{"X":29279,"RHEA_ID":47114,"compounds":"glycochenodeoxycholate + H2O => chenodeoxycholate + glycine"}
{"X":29280,"RHEA_ID":27357,"DIRECTION":"UN","MASTER_ID":27357,"ec":"2.1.1.165","compounds":"iodide + S-adenosyl-L-methionine = iodomethane + S-adenosyl-L-homocysteine"}
{"X":29281,"RHEA_ID":27358,"DIRECTION":"LR","MASTER_ID":27357,"metacyc":"RXN-11241","compounds":"iodide + S-adenosyl-L-methionine => iodomethane + S-adenosyl-L-homocysteine"}
{"X":29282,"RHEA_ID":27359,"compounds":"iodomethane + S-adenosyl-L-homocysteine => iodide + S-adenosyl-L-methionine"}
{"X":29283,"RHEA_ID":47118,"compounds":"H2O + N-eicosanoylglycinate => eicosanoate + glycine"}
{"X":29284,"RHEA_ID":27361,"DIRECTION":"UN","MASTER_ID":27361,"ec":"2.1.1.165","compounds":"chloride + S-adenosyl-L-methionine = chloromethane + S-adenosyl-L-homocysteine"}
{"X":29285,"RHEA_ID":27362,"DIRECTION":"LR","MASTER_ID":27361,"metacyc":"RXN-11267","compounds":"chloride + S-adenosyl-L-methionine => chloromethane + S-adenosyl-L-homocysteine"}
{"X":29286,"RHEA_ID":27363,"compounds":"chloromethane + S-adenosyl-L-homocysteine => chloride + S-adenosyl-L-methionine"}
{"X":29287,"RHEA_ID":37206,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphate <=> 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA"}
{"X":29288,"RHEA_ID":27365,"DIRECTION":"UN","MASTER_ID":27365,"ec":"2.1.1.165","compounds":"bromide + S-adenosyl-L-methionine = bromomethane + S-adenosyl-L-homocysteine"}
{"X":29289,"RHEA_ID":27366,"DIRECTION":"LR","MASTER_ID":27365,"metacyc":"RXN-11268","compounds":"bromide + S-adenosyl-L-methionine => bromomethane + S-adenosyl-L-homocysteine"}
{"X":29290,"RHEA_ID":27367,"compounds":"bromomethane + S-adenosyl-L-homocysteine => bromide + S-adenosyl-L-methionine"}
{"X":29291,"RHEA_ID":37210,"compounds":"(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":29292,"RHEA_ID":27369,"DIRECTION":"UN","MASTER_ID":27369,"ec":"2.3.1.190","compounds":"acetoin + CoA + NAD(+) = acetaldehyde + acetyl-CoA + H(+) + NADH"}
{"X":29293,"RHEA_ID":27370,"DIRECTION":"LR","MASTER_ID":27369,"metacyc":"RXN-9718","compounds":"acetoin + CoA + NAD(+) => acetaldehyde + acetyl-CoA + H(+) + NADH"}
{"X":29294,"RHEA_ID":27371,"compounds":"acetaldehyde + acetyl-CoA + H(+) + NADH => acetoin + CoA + NAD(+)"}
{"X":29295,"RHEA_ID":47130,"compounds":"AMP + deoxycholoyl-CoA + diphosphate => ATP + CoA + deoxycholate"}
{"X":29296,"RHEA_ID":27373,"compounds":"5-amino-6-(D-ribitylamino)uracil + L-tyrosine + 2 S-adenosyl-L-methionine = 2-iminoacetate + 2 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + 2 H(+) + 2 L-methionine + NH4(+)"}
{"X":29297,"RHEA_ID":27374,"DIRECTION":"LR","MASTER_ID":27373,"metacyc":"RXN-8079","compounds":"5-amino-6-(D-ribitylamino)uracil + L-tyrosine + 2 S-adenosyl-L-methionine => 2-iminoacetate + 2 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + 2 H(+) + 2 L-methionine + NH4(+)"}
{"X":29298,"RHEA_ID":27375,"compounds":"2-iminoacetate + 2 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + 2 H(+) + 2 L-methionine + NH4(+) => 5-amino-6-(D-ribitylamino)uracil + L-tyrosine + 2 S-adenosyl-L-methionine"}
{"X":29299,"RHEA_ID":37222,"compounds":"A + D-valine + H2O <=> 3-methyl-2-oxobutanoate + AH2 + NH4(+)"}
{"X":29300,"RHEA_ID":27377,"DIRECTION":"UN","MASTER_ID":27377,"ec":"2.7.1.165","compounds":"(R)-glycerate + ATP = (2R)-2-phosphoglycerate + ADP + H(+)"}
{"X":29301,"RHEA_ID":27378,"DIRECTION":"LR","MASTER_ID":27377,"ecocyc":"GKI-RXN","metacyc":"GKI-RXN","compounds":"(R)-glycerate + ATP => (2R)-2-phosphoglycerate + ADP + H(+)"}
{"X":29302,"RHEA_ID":27379,"compounds":"(2R)-2-phosphoglycerate + ADP + H(+) => (R)-glycerate + ATP"}
{"X":29303,"RHEA_ID":37226,"compounds":"(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate <=> 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphate + CoA"}
{"X":29304,"RHEA_ID":27381,"DIRECTION":"UN","MASTER_ID":27381,"ec":"3.1.3.80","compounds":"(2R)-2,3-bisphosphoglycerate + H2O = (2R)-2-phosphoglycerate + phosphate"}
{"X":29305,"RHEA_ID":27382,"DIRECTION":"LR","MASTER_ID":27381,"metacyc":"RXN-11102","compounds":"(2R)-2,3-bisphosphoglycerate + H2O => (2R)-2-phosphoglycerate + phosphate"}
{"X":29306,"RHEA_ID":27383,"compounds":"(2R)-2-phosphoglycerate + phosphate => (2R)-2,3-bisphosphoglycerate + H2O"}
{"X":29307,"RHEA_ID":47142,"compounds":"(6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => (9Z,12Z)-octadecadienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}
{"X":29308,"RHEA_ID":27385,"DIRECTION":"UN","MASTER_ID":27385,"ec":"3.5.1.107","compounds":"H2O + maleamate = maleate + NH4(+)"}
{"X":29309,"RHEA_ID":27386,"DIRECTION":"LR","MASTER_ID":27385,"metacyc":"RXN-646","compounds":"H2O + maleamate => maleate + NH4(+)"}
{"X":29310,"RHEA_ID":27387,"compounds":"maleate + NH4(+) => H2O + maleamate"}
{"X":29311,"RHEA_ID":37234,"compounds":"H2O + L-alaninamide <=> L-alanine + NH4(+)"}
{"X":29312,"RHEA_ID":27389,"DIRECTION":"UN","MASTER_ID":27389,"ec":"4.1.2.45","compounds":"(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate + H2O = pyruvate + salicylaldehyde"}
{"X":29313,"RHEA_ID":27390,"DIRECTION":"LR","MASTER_ID":27389,"metacyc":"RXN-8615","compounds":"(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate + H2O => pyruvate + salicylaldehyde"}
{"X":29314,"RHEA_ID":27391,"compounds":"pyruvate + salicylaldehyde => (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate + H2O"}
{"X":29315,"RHEA_ID":47150,"compounds":"1,3,7-trimethylurate + a ubiquinol => a ubiquinone + caffeine + H2O"}
{"X":29316,"RHEA_ID":27393,"DIRECTION":"UN","MASTER_ID":27393,"ec":"1.21.98.2","compounds":"2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 = dichlorochromopyrrolate + H(+) + 2 H2O + NH4(+)"}
{"X":29317,"RHEA_ID":27394,"DIRECTION":"LR","MASTER_ID":27393,"metacyc":"RXN-16966","compounds":"2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 => dichlorochromopyrrolate + H(+) + 2 H2O + NH4(+)"}
{"X":29318,"RHEA_ID":27395,"compounds":"dichlorochromopyrrolate + H(+) + 2 H2O + NH4(+) => 2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2"}
{"X":29319,"RHEA_ID":47154,"compounds":"2-oxoglutarate + 2 H(+) + NADH => 2,5-dioxopentanoate + H2O + NAD(+)"}
{"X":29320,"RHEA_ID":27397,"DIRECTION":"UN","MASTER_ID":27397,"ec":"4.3.3.5","compounds":"4'-demethylrebeccamycin + H2O = beta-D-glucose + dichloroarcyriaflavin A"}
{"X":29321,"RHEA_ID":27398,"compounds":"4'-demethylrebeccamycin + H2O => beta-D-glucose + dichloroarcyriaflavin A"}
{"X":29322,"RHEA_ID":27399,"DIRECTION":"RL","MASTER_ID":27397,"metacyc":"RXN-10846","compounds":"beta-D-glucose + dichloroarcyriaflavin A => 4'-demethylrebeccamycin + H2O"}
{"X":29323,"RHEA_ID":47158,"compounds":"7alpha,25-dihydroxy-4-cholesten-3-one + H(+) + NADH => 7alpha,25-dihydroxycholesterol + NAD(+)"}
{"X":29324,"RHEA_ID":27401,"DIRECTION":"UN","MASTER_ID":27401,"ec":"5.99.1.4","compounds":"2-hydroxychromene-2-carboxylate = (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate"}
{"X":29325,"RHEA_ID":27402,"DIRECTION":"LR","MASTER_ID":27401,"metacyc":"RXNN-386","compounds":"2-hydroxychromene-2-carboxylate => (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate"}
{"X":29326,"RHEA_ID":27403,"compounds":"(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate => 2-hydroxychromene-2-carboxylate"}
{"X":29327,"RHEA_ID":37254,"compounds":"cysteamine S-phosphate + H2O <=> cysteamine + phosphate"}
{"X":29328,"RHEA_ID":27405,"DIRECTION":"UN","MASTER_ID":27405,"ec":"1.2.5.1","compounds":"a ubiquinone + H2O + pyruvate = a ubiquinol + acetate + CO2"}
{"X":29329,"RHEA_ID":27406,"DIRECTION":"LR","MASTER_ID":27405,"ecocyc":"RXN-11496","metacyc":"RXN-11496","compounds":"a ubiquinone + H2O + pyruvate => a ubiquinol + acetate + CO2"}
{"X":29330,"RHEA_ID":27407,"compounds":"a ubiquinol + acetate + CO2 => a ubiquinone + H2O + pyruvate"}
{"X":29331,"RHEA_ID":37258,"compounds":"A + D-asparagine + H2O <=> 2-oxosuccinamate + AH2 + NH4(+)"}
{"X":29332,"RHEA_ID":27409,"DIRECTION":"UN","MASTER_ID":27409,"ec":"1.3.5.3","compounds":"3 a menaquinone + protoporphyrinogen IX = 3 a menaquinol + protoporphyrin IX"}
{"X":29333,"RHEA_ID":27410,"DIRECTION":"LR","MASTER_ID":27409,"ecocyc":"RXN0-6259","metacyc":"RXN0-6259","compounds":"3 a menaquinone + protoporphyrinogen IX => 3 a menaquinol + protoporphyrin IX"}
{"X":29334,"RHEA_ID":27411,"compounds":"3 a menaquinol + protoporphyrin IX => 3 a menaquinone + protoporphyrinogen IX"}
{"X":29335,"RHEA_ID":27412,"compounds":"3 a menaquinone + protoporphyrinogen IX <=> 3 a menaquinol + protoporphyrin IX"}
{"X":29336,"RHEA_ID":27413,"DIRECTION":"UN","MASTER_ID":27413,"ec":"1.14.11.32","compounds":"2-oxoglutarate + codeine + O2 = CO2 + formaldehyde + morphine + succinate"}
{"X":29337,"RHEA_ID":27414,"DIRECTION":"LR","MASTER_ID":27413,"metacyc":"RXN-8152","compounds":"2-oxoglutarate + codeine + O2 => CO2 + formaldehyde + morphine + succinate"}
{"X":29338,"RHEA_ID":27415,"compounds":"CO2 + formaldehyde + morphine + succinate => 2-oxoglutarate + codeine + O2"}
{"X":29339,"RHEA_ID":47174,"compounds":"5alpha-cholest-8-en-3-one + CO2 + NADH => 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NAD(+)"}
{"X":29340,"RHEA_ID":27417,"DIRECTION":"UN","MASTER_ID":27417,"ec":"1.17.2.1","compounds":"2 [Fe(III)cytochrome] + H2O + nicotinate = 6-hydroxynicotinate + 2 [Fe(II)cytochrome] + 2 H(+)"}
{"X":29341,"RHEA_ID":27418,"DIRECTION":"LR","MASTER_ID":27417,"metacyc":"NICOTINATE-DEHYDROGENASE-RXN","compounds":"2 [Fe(III)cytochrome] + H2O + nicotinate => 6-hydroxynicotinate + 2 [Fe(II)cytochrome] + 2 H(+)"}
{"X":29342,"RHEA_ID":27419,"compounds":"6-hydroxynicotinate + 2 [Fe(II)cytochrome] + 2 H(+) => 2 [Fe(III)cytochrome] + H2O + nicotinate"}
{"X":29343,"RHEA_ID":47178,"compounds":"(2E)-butenoyl-CoA + H2O => (2R)-hydroxybutanoyl-CoA"}
{"X":29344,"RHEA_ID":27421,"DIRECTION":"UN","MASTER_ID":27421,"ec":"4.2.3.46","compounds":"(2E,6E)-farnesyl diphosphate = (3E,6E)-alpha-farnesene + diphosphate"}
{"X":29345,"RHEA_ID":27422,"DIRECTION":"LR","MASTER_ID":27421,"metacyc":"RXN-8574","compounds":"(2E,6E)-farnesyl diphosphate => (3E,6E)-alpha-farnesene + diphosphate"}
{"X":29346,"RHEA_ID":27423,"compounds":"(3E,6E)-alpha-farnesene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":29347,"RHEA_ID":27424,"compounds":"(2E,6E)-farnesyl diphosphate <=> (3E,6E)-alpha-farnesene + diphosphate"}
{"X":29348,"RHEA_ID":27425,"DIRECTION":"UN","MASTER_ID":27425,"ec":"4.2.3.47","compounds":"(2E,6E)-farnesyl diphosphate = (E)-beta-farnesene + diphosphate"}
{"X":29349,"RHEA_ID":27426,"DIRECTION":"LR","MASTER_ID":27425,"metacyc":"RXN-8422","compounds":"(2E,6E)-farnesyl diphosphate => (E)-beta-farnesene + diphosphate"}
{"X":29350,"RHEA_ID":27427,"compounds":"(E)-beta-farnesene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":29351,"RHEA_ID":37278,"compounds":"H2O + L-alanyl-L-glutamine <=> L-alanine + L-glutamine"}
{"X":29352,"RHEA_ID":27429,"DIRECTION":"UN","MASTER_ID":27429,"ec":"3.1.3.4","compounds":"a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate"}
{"X":29353,"RHEA_ID":27430,"DIRECTION":"LR","MASTER_ID":27429,"metacyc":"PHOSPHATIDATE-PHOSPHATASE-RXN","compounds":"a 1,2-diacyl-sn-glycero-3-phosphate + H2O => a 1,2-diacyl-sn-glycerol + phosphate"}
{"X":29354,"RHEA_ID":27431,"compounds":"a 1,2-diacyl-sn-glycerol + phosphate => a 1,2-diacyl-sn-glycero-3-phosphate + H2O"}
{"X":29355,"RHEA_ID":37282,"compounds":"ATP + H2O + L-alanyl-L-histidine(out) <=> ADP + H(+) + L-alanyl-L-histidine(in) + phosphate"}
{"X":29356,"RHEA_ID":27433,"DIRECTION":"UN","MASTER_ID":27433,"ec":"1.8.1.16","compounds":"2 glutathione amide + NAD(+) = glutathione amide disulfide + H(+) + NADH"}
{"X":29357,"RHEA_ID":27434,"compounds":"2 glutathione amide + NAD(+) => glutathione amide disulfide + H(+) + NADH"}
{"X":29358,"RHEA_ID":27435,"DIRECTION":"RL","MASTER_ID":27433,"metacyc":"RXN-6702","compounds":"glutathione amide disulfide + H(+) + NADH => 2 glutathione amide + NAD(+)"}
{"X":29359,"RHEA_ID":47194,"compounds":"[Co(I) methylated-thiol-specific corrinoid protein] + H(+) + methyl-coenzyme M => [methyl-Co(III) methylated-thiol-specific corrinoid protein] + coenzyme M"}
{"X":29360,"RHEA_ID":27437,"DIRECTION":"UN","MASTER_ID":27437,"ec":"1.11.1.17","compounds":"2 glutathione amide + H2O2 = glutathione amide disulfide + 2 H2O"}
{"X":29361,"RHEA_ID":27438,"DIRECTION":"LR","MASTER_ID":27437,"metacyc":"RXN-6701","compounds":"2 glutathione amide + H2O2 => glutathione amide disulfide + 2 H2O"}
{"X":29362,"RHEA_ID":27439,"compounds":"glutathione amide disulfide + 2 H2O => 2 glutathione amide + H2O2"}
{"X":29363,"RHEA_ID":37290,"compounds":"ATP + H2O + L-alanyl-L-leucine(out) <=> ADP + H(+) + L-alanyl-L-leucine(in) + phosphate"}
{"X":29364,"RHEA_ID":27441,"DIRECTION":"UN","MASTER_ID":27441,"ec":"1.1.1.307","compounds":"NAD(+) + xylitol = D-xylose + H(+) + NADH"}
{"X":29365,"RHEA_ID":27442,"compounds":"NAD(+) + xylitol => D-xylose + H(+) + NADH"}
{"X":29366,"RHEA_ID":27443,"compounds":"D-xylose + H(+) + NADH => NAD(+) + xylitol"}
{"X":29367,"RHEA_ID":37294,"compounds":"H2O + L-alanyl-L-leucine <=> L-alanine + L-leucine"}
{"X":29368,"RHEA_ID":27445,"DIRECTION":"UN","MASTER_ID":27445,"ec":"1.1.1.307","compounds":"NADP(+) + xylitol = D-xylose + H(+) + NADPH"}
{"X":29369,"RHEA_ID":27446,"compounds":"NADP(+) + xylitol => D-xylose + H(+) + NADPH"}
{"X":29370,"RHEA_ID":27447,"compounds":"D-xylose + H(+) + NADPH => NADP(+) + xylitol"}
{"X":29371,"RHEA_ID":37298,"compounds":"ATP + H2O + L-alanyl-L-threonine(out) <=> ADP + H(+) + L-alanyl-L-threonine(in) + phosphate"}
{"X":29372,"RHEA_ID":27449,"DIRECTION":"UN","MASTER_ID":27449,"ec":"3.1.3.81","compounds":"a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + phosphate"}
{"X":29373,"RHEA_ID":27450,"compounds":"a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O => a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + phosphate"}
{"X":29374,"RHEA_ID":37301,"compounds":"L-alanine + L-threonine => H2O + L-alanyl-L-threonine"}
{"X":29375,"RHEA_ID":27452,"DIRECTION":"BI","MASTER_ID":27449,"ecocyc":"RXN0-4461","metacyc":"RXN0-4461","compounds":"a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + phosphate"}
{"X":29376,"RHEA_ID":27452,"DIRECTION":"BI","MASTER_ID":27449,"ecocyc":"RXN0-4461","metacyc":"RXN-11277","compounds":"a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + phosphate"}
{"X":29377,"RHEA_ID":27453,"compounds":"iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH"}
{"X":29378,"RHEA_ID":27454,"DIRECTION":"LR","MASTER_ID":27453,"metacyc":"RXN-11330","compounds":"iodide + L-tyrosine + NADP(+) => 3-iodo-L-tyrosine + NADPH"}
{"X":29379,"RHEA_ID":27455,"DIRECTION":"RL","MASTER_ID":27453,"reactome":"R-HSA-209921.1","compounds":"3-iodo-L-tyrosine + NADPH => iodide + L-tyrosine + NADP(+)"}
{"X":29380,"RHEA_ID":37307,"compounds":"glycyl-L-asparagine + H2O = glycine + L-asparagine"}
{"X":29381,"RHEA_ID":27457,"compounds":"3-iodo-L-tyrosine + iodide + NADP(+) = 3,5-diiodo-L-tyrosine + H(+) + NADPH"}
{"X":29382,"RHEA_ID":37309,"compounds":"glycine + L-asparagine => glycyl-L-asparagine + H2O"}
{"X":29383,"RHEA_ID":27459,"compounds":"3,5-diiodo-L-tyrosine + H(+) + NADPH => 3-iodo-L-tyrosine + iodide + NADP(+)"}
{"X":29384,"RHEA_ID":37311,"compounds":"ATP + glycyl-L-glutamine(out) + H2O = ADP + glycyl-L-glutamine(in) + H(+) + phosphate"}
{"X":29385,"RHEA_ID":27461,"DIRECTION":"UN","MASTER_ID":27461,"ec":"2.7.7.71","compounds":"D-glycero-alpha-D-manno-heptose 1-phosphate + GTP + H(+) = diphosphate + GDP-D-glycero-alpha-D-manno-heptose"}
{"X":29386,"RHEA_ID":37313,"compounds":"ADP + glycyl-L-glutamine(in) + H(+) + phosphate => ATP + glycyl-L-glutamine(out) + H2O"}
{"X":29387,"RHEA_ID":27463,"compounds":"diphosphate + GDP-D-glycero-alpha-D-manno-heptose => D-glycero-alpha-D-manno-heptose 1-phosphate + GTP + H(+)"}
{"X":29388,"RHEA_ID":37315,"compounds":"glycyl-L-glutamine + H2O = glycine + L-glutamine"}
{"X":29389,"RHEA_ID":27465,"DIRECTION":"UN","MASTER_ID":27465,"ec":"2.7.7.70","compounds":"ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) = ADP-D-glycero-beta-D-manno-heptose + diphosphate"}
{"X":29390,"RHEA_ID":37317,"compounds":"glycine + L-glutamine => glycyl-L-glutamine + H2O"}
{"X":29391,"RHEA_ID":27467,"compounds":"ADP-D-glycero-beta-D-manno-heptose + diphosphate => ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+)"}
{"X":29392,"RHEA_ID":37319,"compounds":"ATP + glycyl-L-methionine(out) + H2O = ADP + glycyl-L-methionine(in) + H(+) + phosphate"}
{"X":29393,"RHEA_ID":27469,"DIRECTION":"UN","MASTER_ID":27469,"ec":"3.5.1.105","compounds":"H2O + N,N'-diacetylchitobiose = acetate + N-acetyl-beta-D-glucosaminyl-(1->4)-D-glucosamine"}
{"X":29394,"RHEA_ID":37321,"compounds":"ADP + glycyl-L-methionine(in) + H(+) + phosphate => ATP + glycyl-L-methionine(out) + H2O"}
{"X":29395,"RHEA_ID":27471,"compounds":"acetate + N-acetyl-beta-D-glucosaminyl-(1->4)-D-glucosamine => H2O + N,N'-diacetylchitobiose"}
{"X":29396,"RHEA_ID":37323,"compounds":"glycyl-L-methionine + H2O = glycine + L-methionine"}
{"X":29397,"RHEA_ID":27473,"DIRECTION":"UN","MASTER_ID":27473,"ec":"2.7.1.167","compounds":"ATP + D-glycero-beta-D-manno-heptose 7-phosphate = ADP + D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(+)"}
{"X":29398,"RHEA_ID":37325,"compounds":"glycine + L-methionine => glycyl-L-methionine + H2O"}
{"X":29399,"RHEA_ID":27475,"compounds":"ADP + D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(+) => ATP + D-glycero-beta-D-manno-heptose 7-phosphate"}
{"X":29400,"RHEA_ID":37327,"compounds":"ATP + H2O + L-methionyl-L-alanine(out) = ADP + H(+) + L-methionyl-L-alanine(in) + phosphate"}
{"X":29401,"RHEA_ID":27477,"DIRECTION":"UN","MASTER_ID":27477,"ec":"1.14.11.31","compounds":"2-oxoglutarate + O2 + thebaine = CO2 + formaldehyde + neopinone + succinate"}
{"X":29402,"RHEA_ID":37329,"compounds":"ADP + H(+) + L-methionyl-L-alanine(in) + phosphate => ATP + H2O + L-methionyl-L-alanine(out)"}
{"X":29403,"RHEA_ID":27479,"compounds":"CO2 + formaldehyde + neopinone + succinate => 2-oxoglutarate + O2 + thebaine"}
{"X":29404,"RHEA_ID":37331,"compounds":"H2O + L-methionyl-L-alanine = L-alanine + L-methionine"}
{"X":29405,"RHEA_ID":27481,"DIRECTION":"UN","MASTER_ID":27481,"ec":"1.14.14.148","compounds":"(S)-columbianetin + O2 + reduced [NADPH--hemoprotein reductase] = acetone + angelicin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":29406,"RHEA_ID":37333,"compounds":"L-alanine + L-methionine => H2O + L-methionyl-L-alanine"}
{"X":29407,"RHEA_ID":27483,"compounds":"acetone + angelicin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-columbianetin + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":29408,"RHEA_ID":37335,"DIRECTION":"UN","MASTER_ID":37335,"ec":"3.5.2.2","compounds":"5,6-dihydrothymine + H2O = 3-(carbamoylamino)-2-methylpropanoate + H(+)"}
{"X":29409,"RHEA_ID":27485,"DIRECTION":"UN","MASTER_ID":27485,"ec":"3.5.3.9","compounds":"allantoate + 2 H(+) + H2O = (S)-2-ureidoglycine + CO2 + NH4(+)"}
{"X":29410,"RHEA_ID":37337,"compounds":"3-(carbamoylamino)-2-methylpropanoate + H(+) => 5,6-dihydrothymine + H2O"}
{"X":29411,"RHEA_ID":27487,"compounds":"(S)-2-ureidoglycine + CO2 + NH4(+) => allantoate + 2 H(+) + H2O"}
{"X":29412,"RHEA_ID":37339,"DIRECTION":"UN","MASTER_ID":37339,"ec":"3.5.1.6","compounds":"3-(carbamoylamino)-2-methylpropanoate + 2 H(+) + H2O = (R)-3-amino-2-methylpropanoate + CO2 + NH4(+)"}
{"X":29413,"RHEA_ID":27489,"DIRECTION":"UN","MASTER_ID":27489,"ec":"5.3.1.28","compounds":"2 D-sedoheptulose 7-phosphate = D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate"}
{"X":29414,"RHEA_ID":27490,"DIRECTION":"LR","MASTER_ID":27489,"ecocyc":"RXN0-4301","metacyc":"RXN0-4301","compounds":"2 D-sedoheptulose 7-phosphate => D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate"}
{"X":29415,"RHEA_ID":27491,"compounds":"D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate => 2 D-sedoheptulose 7-phosphate"}
{"X":29416,"RHEA_ID":37343,"compounds":"adenosine 2'-phosphate + H2O = adenosine + phosphate"}
{"X":29417,"RHEA_ID":27493,"compounds":"S-adenosyl-L-methionine + tricetin = 3'-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine"}
{"X":29418,"RHEA_ID":27494,"DIRECTION":"LR","MASTER_ID":27493,"metacyc":"RXN-11582","compounds":"S-adenosyl-L-methionine + tricetin => 3'-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine"}
{"X":29419,"RHEA_ID":27495,"compounds":"3'-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + tricetin"}
{"X":29420,"RHEA_ID":37347,"DIRECTION":"UN","MASTER_ID":37347,"ec":"6.1.2.1","compounds":"(R)-lactate + ATP + D-alanine = ADP + D-alanyl-(R)-lactate + phosphate"}
{"X":29421,"RHEA_ID":27497,"compounds":"3'-O-methyltricetin + S-adenosyl-L-methionine = 3',5'-di-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine"}
{"X":29422,"RHEA_ID":37349,"compounds":"ADP + D-alanyl-(R)-lactate + phosphate => (R)-lactate + ATP + D-alanine"}
{"X":29423,"RHEA_ID":27499,"compounds":"3',5'-di-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine => 3'-O-methyltricetin + S-adenosyl-L-methionine"}
{"X":29424,"RHEA_ID":37351,"compounds":"cytidine 2'-phosphate + H2O = cytidine + phosphate"}
{"X":29425,"RHEA_ID":27501,"compounds":"3',5'-di-O-methyltricetin + S-adenosyl-L-methionine = 3',4',5'-O-trimethyltricetin + H(+) + S-adenosyl-L-homocysteine"}
{"X":29426,"RHEA_ID":27502,"DIRECTION":"LR","MASTER_ID":27501,"metacyc":"RXN-11584","compounds":"3',5'-di-O-methyltricetin + S-adenosyl-L-methionine => 3',4',5'-O-trimethyltricetin + H(+) + S-adenosyl-L-homocysteine"}
{"X":29427,"RHEA_ID":27503,"compounds":"3',4',5'-O-trimethyltricetin + H(+) + S-adenosyl-L-homocysteine => 3',5'-di-O-methyltricetin + S-adenosyl-L-methionine"}
{"X":29428,"RHEA_ID":37355,"compounds":"H2O + uridine 2'-phosphate = phosphate + uridine"}
{"X":29429,"RHEA_ID":27506,"DIRECTION":"UN","MASTER_ID":27506,"ec":"3.1.1.84","compounds":"cocaine + H2O = benzoate + ecgonine methyl ester + H(+)"}
{"X":29430,"RHEA_ID":37357,"compounds":"phosphate + uridine => H2O + uridine 2'-phosphate"}
{"X":29431,"RHEA_ID":27508,"compounds":"benzoate + ecgonine methyl ester + H(+) => cocaine + H2O"}
{"X":29432,"RHEA_ID":37359,"compounds":"D-glucosamine(out) + N(pros)-phospho-L-histidyl-[protein] = D-glucosamine 6-phosphate(in) + L-histidyl-[protein]"}
{"X":29433,"RHEA_ID":27510,"DIRECTION":"UN","MASTER_ID":27510,"ec":"2.7.8.28","compounds":"7,8-didemethyl-8-hydroxy-5-deazariboflavin + enolpyruvoyl-2-diphospho-5'-guanosine = dehydro F420-0 + GMP + H(+)"}
{"X":29434,"RHEA_ID":27511,"DIRECTION":"LR","MASTER_ID":27510,"metacyc":"RXN-8078","compounds":"7,8-didemethyl-8-hydroxy-5-deazariboflavin + enolpyruvoyl-2-diphospho-5'-guanosine => dehydro F420-0 + GMP + H(+)"}
{"X":29435,"RHEA_ID":27512,"compounds":"dehydro F420-0 + GMP + H(+) => 7,8-didemethyl-8-hydroxy-5-deazariboflavin + enolpyruvoyl-2-diphospho-5'-guanosine"}
{"X":29436,"RHEA_ID":37363,"DIRECTION":"UN","MASTER_ID":37363,"ec":"1.14.99.48","compounds":"5 AH2 + 2 H(+) + heme b + 4 O2 = 5 A + beta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O"}
{"X":29437,"RHEA_ID":27514,"compounds":"H2O + sphinganine 1-phosphate = phosphate + sphinganine"}
{"X":29438,"RHEA_ID":27515,"DIRECTION":"LR","MASTER_ID":27514,"metacyc":"DHS-PHOSPHATASE-RXN","reactome":"R-HSA-428664.1","compounds":"H2O + sphinganine 1-phosphate => phosphate + sphinganine"}
{"X":29439,"RHEA_ID":27516,"compounds":"phosphate + sphinganine => H2O + sphinganine 1-phosphate"}
{"X":29440,"RHEA_ID":47275,"DIRECTION":"BI","MASTER_ID":47272,"metacyc":"RXN-16710","compounds":"monoanhydrobacterioruberin <=> bisanhydrobacterioruberin + H2O"}
{"X":29441,"RHEA_ID":27518,"compounds":"H2O + sphing-4-enine 1-phosphate = phosphate + sphing-4-enine"}
{"X":29442,"RHEA_ID":27519,"DIRECTION":"LR","MASTER_ID":27518,"metacyc":"RXN3DJ-25","reactome":"R-HSA-428701.1","compounds":"H2O + sphing-4-enine 1-phosphate => phosphate + sphing-4-enine"}
{"X":29443,"RHEA_ID":27519,"DIRECTION":"LR","MASTER_ID":27518,"metacyc":"RXN3DJ-25","reactome":"R-HSA-428696.1","compounds":"H2O + sphing-4-enine 1-phosphate => phosphate + sphing-4-enine"}
{"X":29444,"RHEA_ID":37371,"DIRECTION":"UN","MASTER_ID":37371,"ec":"3.6.1.62","compounds":"a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + H2O = a 5'-end (purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methylguanosine 5'-diphosphate"}
{"X":29445,"RHEA_ID":27520,"compounds":"phosphate + sphing-4-enine => H2O + sphing-4-enine 1-phosphate"}
{"X":29446,"RHEA_ID":27521,"compounds":"H2O + sphing-4-enine 1-phosphate <=> phosphate + sphing-4-enine"}
{"X":29447,"RHEA_ID":27522,"DIRECTION":"UN","MASTER_ID":27522,"ec":"1.13.11.9","compounds":"2,5-dihydroxypyridine + O2 = H(+) + N-formylmaleamate"}
{"X":29448,"RHEA_ID":37375,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine = 1-(9Z-octadecenoyl)-2-(9Z,12Z-octadienoyl)-sn-glycero-3-phospho-L-serine + CoA"}
{"X":29449,"RHEA_ID":27524,"compounds":"H(+) + N-formylmaleamate => 2,5-dihydroxypyridine + O2"}
{"X":29450,"RHEA_ID":37377,"compounds":"1-(9Z-octadecenoyl)-2-(9Z,12Z-octadienoyl)-sn-glycero-3-phospho-L-serine + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine"}
{"X":29451,"RHEA_ID":27526,"DIRECTION":"UN","MASTER_ID":27526,"ec":"3.1.7.6","compounds":"(2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-farnesol + diphosphate"}
{"X":29452,"RHEA_ID":37379,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine = 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA"}
{"X":29453,"RHEA_ID":27528,"compounds":"(2E,6E)-farnesol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}
{"X":29454,"RHEA_ID":27529,"compounds":"(2E,6E)-farnesyl diphosphate + H2O <=> (2E,6E)-farnesol + diphosphate"}
{"X":29455,"RHEA_ID":27530,"DIRECTION":"UN","MASTER_ID":27530,"ec":"4.2.3.48","compounds":"(2E,6E)-farnesyl diphosphate + H2O = (3S,6E)-nerolidol + diphosphate"}
{"X":29456,"RHEA_ID":37383,"compounds":"a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":29457,"RHEA_ID":27532,"compounds":"(3S,6E)-nerolidol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}
{"X":29458,"RHEA_ID":37385,"compounds":"1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA"}
{"X":29459,"RHEA_ID":27534,"DIRECTION":"UN","MASTER_ID":27534,"ec":"4.2.3.49","compounds":"(2E,6E)-farnesyl diphosphate + H2O = (3R,6E)-nerolidol + diphosphate"}
{"X":29460,"RHEA_ID":37387,"compounds":"(9Z)-octadecenoyl-CoA + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":29461,"RHEA_ID":27536,"compounds":"(3R,6E)-nerolidol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}
{"X":29462,"RHEA_ID":37389,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}
{"X":29463,"RHEA_ID":27538,"DIRECTION":"UN","MASTER_ID":27538,"ec":"1.1.99.36","compounds":"ethanol + N,N-dimethyl-4-nitrosoaniline = 4-(hydroxylamino)-N,N-dimethylaniline + acetaldehyde"}
{"X":29464,"RHEA_ID":27539,"compounds":"ethanol + N,N-dimethyl-4-nitrosoaniline => 4-(hydroxylamino)-N,N-dimethylaniline + acetaldehyde"}
{"X":29465,"RHEA_ID":37392,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-(9Z)-octadecaenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":29466,"RHEA_ID":37393,"compounds":"1-(9Z)-octadecaenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA => (9Z,12Z)-octadecadienoyl-CoA + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}
{"X":29467,"RHEA_ID":27542,"compounds":"methanol + N,N-dimethyl-4-nitrosoaniline = 4-(hydroxylamino)-N,N-dimethylaniline + formaldehyde"}
{"X":29468,"RHEA_ID":27543,"DIRECTION":"LR","MASTER_ID":27542,"metacyc":"RXN-11451","compounds":"methanol + N,N-dimethyl-4-nitrosoaniline => 4-(hydroxylamino)-N,N-dimethylaniline + formaldehyde"}
{"X":29469,"RHEA_ID":27544,"compounds":"4-(hydroxylamino)-N,N-dimethylaniline + formaldehyde => methanol + N,N-dimethyl-4-nitrosoaniline"}
{"X":29470,"RHEA_ID":37397,"compounds":"1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}
{"X":29471,"RHEA_ID":27546,"DIRECTION":"UN","MASTER_ID":27546,"ec":"1.14.14.8","compounds":"anthranilate + FADH2 + O2 = 3-hydroxyanthranilate + FAD + H(+) + H2O"}
{"X":29472,"RHEA_ID":27547,"DIRECTION":"LR","MASTER_ID":27546,"metacyc":"RXN-10724","compounds":"anthranilate + FADH2 + O2 => 3-hydroxyanthranilate + FAD + H(+) + H2O"}
{"X":29473,"RHEA_ID":37400,"compounds":"(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine => 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-L-serine + CoA"}
{"X":29474,"RHEA_ID":37401,"compounds":"1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-L-serine + CoA => (9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine"}
{"X":29475,"RHEA_ID":27551,"DIRECTION":"UN","MASTER_ID":27551,"ec":"2.5.1.31","compounds":"(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate = di-trans,octa-cis-undecaprenyl diphosphate + 8 diphosphate"}
{"X":29476,"RHEA_ID":27552,"DIRECTION":"LR","MASTER_ID":27551,"ecocyc":"RXN-8999","metacyc":"RXN-8999","compounds":"(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate => di-trans,octa-cis-undecaprenyl diphosphate + 8 diphosphate"}
{"X":29477,"RHEA_ID":37404,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + octadecanoyl-CoA => 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serine + CoA"}
{"X":29478,"RHEA_ID":37405,"compounds":"1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serine + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + octadecanoyl-CoA"}
{"X":29479,"RHEA_ID":27555,"DIRECTION":"UN","MASTER_ID":27555,"ec":"2.5.1.82","compounds":"all-trans-geranylgeranyl diphosphate + 2 isopentenyl diphosphate = all-trans-hexaprenyl diphosphate + 2 diphosphate"}
{"X":29480,"RHEA_ID":27556,"compounds":"all-trans-geranylgeranyl diphosphate + 2 isopentenyl diphosphate => all-trans-hexaprenyl diphosphate + 2 diphosphate"}
{"X":29481,"RHEA_ID":37408,"compounds":"(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine => 1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + CoA"}
{"X":29482,"RHEA_ID":37409,"compounds":"1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine"}
{"X":29483,"RHEA_ID":27559,"DIRECTION":"UN","MASTER_ID":27559,"ec":"2.5.1.83","compounds":"(2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate = all-trans-hexaprenyl diphosphate + 3 diphosphate"}
{"X":29484,"RHEA_ID":27560,"compounds":"(2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate => all-trans-hexaprenyl diphosphate + 3 diphosphate"}
{"X":29485,"RHEA_ID":27561,"compounds":"all-trans-hexaprenyl diphosphate + 3 diphosphate => (2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate"}
{"X":29486,"RHEA_ID":37413,"DIRECTION":"RL","MASTER_ID":37411,"metacyc":"RXN-14818","compounds":"aklaviketone + 2 H(+) + NADPH => aklavinone + NADP(+)"}
{"X":29487,"RHEA_ID":27563,"DIRECTION":"UN","MASTER_ID":27563,"ec":"2.5.1.84","compounds":"(2E)-geranyl diphosphate + 7 isopentenyl diphosphate = all-trans-nonaprenyl diphosphate + 7 diphosphate"}
{"X":29488,"RHEA_ID":27564,"DIRECTION":"LR","MASTER_ID":27563,"metacyc":"TRANS-OCTAPRENYLTRANSTRANSFERASE-RXN","compounds":"(2E)-geranyl diphosphate + 7 isopentenyl diphosphate => all-trans-nonaprenyl diphosphate + 7 diphosphate"}
{"X":29489,"RHEA_ID":37416,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA => 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphoserine + CoA"}
{"X":29490,"RHEA_ID":37417,"compounds":"1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphoserine + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA"}
{"X":29491,"RHEA_ID":27570,"DIRECTION":"UN","MASTER_ID":27570,"ec":"2.7.1.168","compounds":"ATP + D-glycero-alpha-D-manno-heptose 7-phosphate = ADP + D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H(+)"}
{"X":29492,"RHEA_ID":27571,"DIRECTION":"LR","MASTER_ID":27570,"metacyc":"RXN-11364","compounds":"ATP + D-glycero-alpha-D-manno-heptose 7-phosphate => ADP + D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H(+)"}
{"X":29493,"RHEA_ID":27572,"compounds":"ADP + D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H(+) => ATP + D-glycero-alpha-D-manno-heptose 7-phosphate"}
{"X":29494,"RHEA_ID":37421,"compounds":"1-hexadecanoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":29495,"RHEA_ID":27574,"DIRECTION":"UN","MASTER_ID":27574,"ec":"3.5.1.100","compounds":"(3R)-piperidine-3-carboxamide + H2O = (3R)-piperidine-3-carboxylate + NH4(+)"}
{"X":29496,"RHEA_ID":27575,"compounds":"(3R)-piperidine-3-carboxamide + H2O => (3R)-piperidine-3-carboxylate + NH4(+)"}
{"X":29497,"RHEA_ID":27576,"compounds":"(3R)-piperidine-3-carboxylate + NH4(+) => (3R)-piperidine-3-carboxamide + H2O"}
{"X":29498,"RHEA_ID":27577,"DIRECTION":"BI","MASTER_ID":27574,"metacyc":"RXN-14173","compounds":"(3R)-piperidine-3-carboxamide + H2O <=> (3R)-piperidine-3-carboxylate + NH4(+)"}
{"X":29499,"RHEA_ID":27578,"DIRECTION":"UN","MASTER_ID":27578,"ec":"3.5.1.100","compounds":"(R)-N-tert-butylpiperazine-2-carboxamide + H2O = (R)-piperazine-2-carboxylate + tert-butylamine"}
{"X":29500,"RHEA_ID":27579,"compounds":"(R)-N-tert-butylpiperazine-2-carboxamide + H2O => (R)-piperazine-2-carboxylate + tert-butylamine"}
{"X":29501,"RHEA_ID":37428,"compounds":"(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate => a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":29502,"RHEA_ID":27581,"DIRECTION":"BI","MASTER_ID":27578,"metacyc":"RXN-14174","compounds":"(R)-N-tert-butylpiperazine-2-carboxamide + H2O <=> (R)-piperazine-2-carboxylate + tert-butylamine"}
{"X":29503,"RHEA_ID":27582,"compounds":"2-(hydroxymethyl)glutarate = 2-methyleneglutarate + H2O"}
{"X":29504,"RHEA_ID":27583,"DIRECTION":"LR","MASTER_ID":27582,"metacyc":"RXN-7640","compounds":"2-(hydroxymethyl)glutarate => 2-methyleneglutarate + H2O"}
{"X":29505,"RHEA_ID":37432,"DIRECTION":"LR","MASTER_ID":37431,"metacyc":"RXN-15809","compounds":"12,18-didecarboxysiroheme + 2 AH2 + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + 2 A + 2 acetate + Fe-coproporphyrin III + 2 H(+) + 2 L-methionine"}
{"X":29506,"RHEA_ID":37433,"compounds":"2 5'-deoxyadenosine + 2 A + 2 acetate + Fe-coproporphyrin III + 2 H(+) + 2 L-methionine => 12,18-didecarboxysiroheme + 2 AH2 + 2 S-adenosyl-L-methionine"}
{"X":29507,"RHEA_ID":27586,"DIRECTION":"UN","MASTER_ID":27586,"ec":"2.6.1.99","compounds":"L-tryptophan + pyruvate = indole-3-pyruvate + L-alanine"}
{"X":29508,"RHEA_ID":27587,"compounds":"L-tryptophan + pyruvate => indole-3-pyruvate + L-alanine"}
{"X":29509,"RHEA_ID":27588,"compounds":"indole-3-pyruvate + L-alanine => L-tryptophan + pyruvate"}
{"X":29510,"RHEA_ID":37437,"compounds":"a 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA => (9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphate"}
{"X":29511,"RHEA_ID":27590,"DIRECTION":"UN","MASTER_ID":27590,"ec":"6.3.2.44","compounds":"(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + ADP + H(+) + phosphate"}
{"X":29512,"RHEA_ID":27591,"DIRECTION":"LR","MASTER_ID":27590,"metacyc":"RXN-14175","compounds":"(R)-pantoate + ATP + beta-alanine => (R)-pantothenate + ADP + H(+) + phosphate"}
{"X":29513,"RHEA_ID":37440,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate => a 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA"}
{"X":29514,"RHEA_ID":37441,"compounds":"a 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate"}
{"X":29515,"RHEA_ID":27594,"DIRECTION":"UN","MASTER_ID":27594,"ec":"2.5.1.85","compounds":"all-trans-geranylgeranyl diphosphate + 5 isopentenyl diphosphate = all-trans-nonaprenyl diphosphate + 5 diphosphate"}
{"X":29516,"RHEA_ID":27595,"DIRECTION":"LR","MASTER_ID":27594,"metacyc":"RXN-11486","compounds":"all-trans-geranylgeranyl diphosphate + 5 isopentenyl diphosphate => all-trans-nonaprenyl diphosphate + 5 diphosphate"}
{"X":29517,"RHEA_ID":37444,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA"}
{"X":29518,"RHEA_ID":37445,"compounds":"1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate"}
{"X":29519,"RHEA_ID":27602,"DIRECTION":"UN","MASTER_ID":27602,"ec":"2.5.1.88","compounds":"(2Z,6E)-farnesyl diphosphate + 9 isopentenyl diphosphate = di-trans,nona-cis-dodecaprenyl diphosphate + 9 diphosphate"}
{"X":29520,"RHEA_ID":27603,"compounds":"(2Z,6E)-farnesyl diphosphate + 9 isopentenyl diphosphate => di-trans,nona-cis-dodecaprenyl diphosphate + 9 diphosphate"}
{"X":29521,"RHEA_ID":37448,"DIRECTION":"LR","MASTER_ID":37447,"metacyc":"RXN-14695","compounds":"O2 + tetracenomycin F1 => H(+) + H2O + tetracenomycin D3"}
{"X":29522,"RHEA_ID":27605,"DIRECTION":"BI","MASTER_ID":27602,"metacyc":"RXN-11487","compounds":"(2Z,6E)-farnesyl diphosphate + 9 isopentenyl diphosphate <=> di-trans,nona-cis-dodecaprenyl diphosphate + 9 diphosphate"}
{"X":29523,"RHEA_ID":27606,"DIRECTION":"UN","MASTER_ID":27606,"ec":"2.7.8.29","compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine = 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine"}
{"X":29524,"RHEA_ID":27607,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine => 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine"}
{"X":29525,"RHEA_ID":37452,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + eicosanoyl-CoA => 1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphate + CoA"}
{"X":29526,"RHEA_ID":27610,"compounds":"formate + H(+) = CO2 + H2"}
{"X":29527,"RHEA_ID":27611,"DIRECTION":"LR","MASTER_ID":27610,"ecocyc":"FHLMULTI-RXN","metacyc":"FHLMULTI-RXN","compounds":"formate + H(+) => CO2 + H2"}
{"X":29528,"RHEA_ID":37456,"compounds":"(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate => 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}
{"X":29529,"RHEA_ID":27613,"compounds":"formate + H(+) <=> CO2 + H2"}
{"X":29530,"RHEA_ID":27614,"DIRECTION":"UN","MASTER_ID":27614,"ec":"2.5.1.88","compounds":"(2Z,6E)-farnesyl diphosphate + 10 isopentenyl diphosphate = di-trans,deca-cis-tridecaprenyl diphosphate + 10 diphosphate"}
{"X":29531,"RHEA_ID":27615,"compounds":"(2Z,6E)-farnesyl diphosphate + 10 isopentenyl diphosphate => di-trans,deca-cis-tridecaprenyl diphosphate + 10 diphosphate"}
{"X":29532,"RHEA_ID":37460,"DIRECTION":"LR","MASTER_ID":37459,"metacyc":"RXN-10972","reactome":"R-HSA-1855216.2","compounds":"1D-myo-inositol hexakisphosphate + ATP => 1-diphospho-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP"}
{"X":29533,"RHEA_ID":27617,"compounds":"(2Z,6E)-farnesyl diphosphate + 10 isopentenyl diphosphate <=> di-trans,deca-cis-tridecaprenyl diphosphate + 10 diphosphate"}
{"X":29534,"RHEA_ID":27618,"DIRECTION":"UN","MASTER_ID":27618,"ec":"2.5.1.88","compounds":"(2Z,6E)-farnesyl diphosphate + 11 isopentenyl diphosphate = di-trans,undeca-cis-tetradecaprenyl diphosphate + 11 diphosphate"}
{"X":29535,"RHEA_ID":27619,"compounds":"(2Z,6E)-farnesyl diphosphate + 11 isopentenyl diphosphate => di-trans,undeca-cis-tetradecaprenyl diphosphate + 11 diphosphate"}
{"X":29536,"RHEA_ID":37464,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + sn-glycerol 3-phosphate => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":29537,"RHEA_ID":27621,"compounds":"(2Z,6E)-farnesyl diphosphate + 11 isopentenyl diphosphate <=> di-trans,undeca-cis-tetradecaprenyl diphosphate + 11 diphosphate"}
{"X":29538,"RHEA_ID":27622,"DIRECTION":"UN","MASTER_ID":27622,"ec":"2.5.1.89","compounds":"geranylgeranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + tri-trans,hepta-cis-undecaprenyl diphosphate"}
{"X":29539,"RHEA_ID":27623,"compounds":"geranylgeranyl diphosphate + 7 isopentenyl diphosphate => 7 diphosphate + tri-trans,hepta-cis-undecaprenyl diphosphate"}
{"X":29540,"RHEA_ID":37468,"DIRECTION":"LR","MASTER_ID":37467,"metacyc":"RXN-10974","reactome":"R-HSA-1855194.2","compounds":"1-diphospho-myo-inositol 2,3,4,5,6-pentakisphosphate + ATP + H(+) => 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP"}
{"X":29541,"RHEA_ID":37468,"DIRECTION":"LR","MASTER_ID":37467,"metacyc":"RXN-10974","reactome":"R-HSA-1855157.2","compounds":"1-diphospho-myo-inositol 2,3,4,5,6-pentakisphosphate + ATP + H(+) => 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP"}
{"X":29542,"RHEA_ID":27626,"DIRECTION":"UN","MASTER_ID":27626,"ec":"2.2.1.1","compounds":"D-erythrose 4-phosphate + D-xylulose 5-phosphate = beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate"}
{"X":29543,"RHEA_ID":27627,"compounds":"D-erythrose 4-phosphate + D-xylulose 5-phosphate => beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate"}
{"X":29544,"RHEA_ID":27628,"compounds":"beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate => D-erythrose 4-phosphate + D-xylulose 5-phosphate"}
{"X":29545,"RHEA_ID":47381,"compounds":"(25R)-3beta-hydroxycholest-5-en-7-one-26-al + H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta-hydroxycholest-5-en-7-one-26-oate + H2O + 2 oxidized [adrenodoxin]"}
{"X":29546,"RHEA_ID":27630,"compounds":"ethylene glycol + NAD(+) = glycolaldehyde + H(+) + NADH"}
{"X":29547,"RHEA_ID":27631,"compounds":"ethylene glycol + NAD(+) => glycolaldehyde + H(+) + NADH"}
{"X":29548,"RHEA_ID":27632,"compounds":"glycolaldehyde + H(+) + NADH => ethylene glycol + NAD(+)"}
{"X":29549,"RHEA_ID":37476,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":29550,"RHEA_ID":27634,"compounds":"5-dehydro-D-gluconate + NADP(+) = 2,5-didehydro-D-gluconate + H(+) + NADPH"}
{"X":29551,"RHEA_ID":27635,"compounds":"5-dehydro-D-gluconate + NADP(+) => 2,5-didehydro-D-gluconate + H(+) + NADPH"}
{"X":29552,"RHEA_ID":27636,"DIRECTION":"RL","MASTER_ID":27634,"ecocyc":"YIAE1-RXN","metacyc":"YIAE1-RXN","compounds":"2,5-didehydro-D-gluconate + H(+) + NADPH => 5-dehydro-D-gluconate + NADP(+)"}
{"X":29553,"RHEA_ID":47389,"compounds":"H2O + tetradecanoate ester => an aliphatic alcohol + H(+) + tetradecanoate"}
{"X":29554,"RHEA_ID":27638,"DIRECTION":"UN","MASTER_ID":27638,"ec":"2.4.2.1","compounds":"phosphate + xanthosine = alpha-D-ribose 1-phosphate + xanthine"}
{"X":29555,"RHEA_ID":27639,"DIRECTION":"LR","MASTER_ID":27638,"ecocyc":"XANTHOSINEPHOSPHORY-RXN","metacyc":"XANTHOSINEPHOSPHORY-RXN","compounds":"phosphate + xanthosine => alpha-D-ribose 1-phosphate + xanthine"}
{"X":29556,"RHEA_ID":27640,"compounds":"alpha-D-ribose 1-phosphate + xanthine => phosphate + xanthosine"}
{"X":29557,"RHEA_ID":47393,"compounds":"H2O + hexadecanoate ester => an aliphatic alcohol + H(+) + hexadecanoate"}
{"X":29558,"RHEA_ID":27642,"DIRECTION":"UN","MASTER_ID":27642,"ec":"2.4.2.1","compounds":"adenosine + phosphate = adenine + alpha-D-ribose 1-phosphate"}
{"X":29559,"RHEA_ID":27643,"compounds":"adenosine + phosphate => adenine + alpha-D-ribose 1-phosphate"}
{"X":29560,"RHEA_ID":27644,"compounds":"adenine + alpha-D-ribose 1-phosphate => adenosine + phosphate"}
{"X":29561,"RHEA_ID":37488,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphocholine => 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":29562,"RHEA_ID":27646,"DIRECTION":"UN","MASTER_ID":27646,"ec":"2.4.2.1","compounds":"inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine"}
{"X":29563,"RHEA_ID":27647,"compounds":"inosine + phosphate => alpha-D-ribose 1-phosphate + hypoxanthine"}
{"X":29564,"RHEA_ID":27648,"compounds":"alpha-D-ribose 1-phosphate + hypoxanthine => inosine + phosphate"}
{"X":29565,"RHEA_ID":47401,"compounds":"3-oxo-(9Z-octadecenoyl)-CoA + CoA => (7Z)-hexadecenoyl-CoA + acetyl-CoA"}
{"X":29566,"RHEA_ID":27650,"compounds":"GTP + uridine = GDP + H(+) + UMP"}
{"X":29567,"RHEA_ID":27651,"compounds":"GTP + uridine => GDP + H(+) + UMP"}
{"X":29568,"RHEA_ID":27652,"compounds":"GDP + H(+) + UMP => GTP + uridine"}
{"X":29569,"RHEA_ID":47405,"compounds":"(24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA + NAD(+) => 3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH"}
{"X":29570,"RHEA_ID":27654,"DIRECTION":"UN","MASTER_ID":27654,"ec":"2.2.1.6","compounds":"2-oxobutanoate + H(+) + pyruvate = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + CO2"}
{"X":29571,"RHEA_ID":27655,"DIRECTION":"LR","MASTER_ID":27654,"ecocyc":"ACETOOHBUTSYN-RXN","metacyc":"ACETOOHBUTSYN-RXN","compounds":"2-oxobutanoate + H(+) + pyruvate => (S)-2-ethyl-2-hydroxy-3-oxobutanoate + CO2"}
{"X":29572,"RHEA_ID":27656,"compounds":"(S)-2-ethyl-2-hydroxy-3-oxobutanoate + CO2 => 2-oxobutanoate + H(+) + pyruvate"}
{"X":29573,"RHEA_ID":47409,"compounds":"(24E)-3alpha,7alpha-dihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O => (24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA"}
{"X":29574,"RHEA_ID":27658,"DIRECTION":"UN","MASTER_ID":27658,"ec":"5.4.2.7","compounds":"2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-D-ribose 5-phosphate"}
{"X":29575,"RHEA_ID":27659,"compounds":"2-deoxy-alpha-D-ribose 1-phosphate => 2-deoxy-D-ribose 5-phosphate"}
{"X":29576,"RHEA_ID":27660,"compounds":"2-deoxy-D-ribose 5-phosphate => 2-deoxy-alpha-D-ribose 1-phosphate"}
{"X":29577,"RHEA_ID":37504,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":29578,"RHEA_ID":37505,"compounds":"1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":29579,"RHEA_ID":27663,"DIRECTION":"LR","MASTER_ID":27662,"ecocyc":"RXN0-5364","metacyc":"RXN0-5364","compounds":"(S)-2-hydroxyglutarate + O2 => 2-oxoglutarate + H2O2"}
{"X":29580,"RHEA_ID":27664,"compounds":"2-oxoglutarate + H2O2 => (S)-2-hydroxyglutarate + O2"}
{"X":29581,"RHEA_ID":27665,"compounds":"(S)-2-hydroxyglutarate + O2 <=> 2-oxoglutarate + H2O2"}
{"X":29582,"RHEA_ID":27666,"compounds":"(R)-methylmalonyl-CoA + H(+) = CO2 + propanoyl-CoA"}
{"X":29583,"RHEA_ID":27667,"DIRECTION":"LR","MASTER_ID":27666,"ecocyc":"RXN0-310","metacyc":"RXN0-310","compounds":"(R)-methylmalonyl-CoA + H(+) => CO2 + propanoyl-CoA"}
{"X":29584,"RHEA_ID":27668,"compounds":"CO2 + propanoyl-CoA => (R)-methylmalonyl-CoA + H(+)"}
{"X":29585,"RHEA_ID":37516,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + dodecanoyl-CoA => 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":29586,"RHEA_ID":37517,"compounds":"1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + dodecanoyl-CoA"}
{"X":29587,"RHEA_ID":27671,"DIRECTION":"LR","MASTER_ID":27670,"ecocyc":"RXN0-5408","metacyc":"RXN0-5408","reactome":"R-HSA-1855154.2","compounds":"1D-myo-inositol 1-phosphate + H2O => myo-inositol + phosphate"}
{"X":29588,"RHEA_ID":27672,"compounds":"myo-inositol + phosphate => 1D-myo-inositol 1-phosphate + H2O"}
{"X":29589,"RHEA_ID":37520,"compounds":"(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":29590,"RHEA_ID":37521,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine"}
{"X":29591,"RHEA_ID":27675,"DIRECTION":"LR","MASTER_ID":27674,"ecocyc":"DADPKIN-RXN","metacyc":"DADPKIN-RXN","compounds":"ATP + dADP => ADP + dATP"}
{"X":29592,"RHEA_ID":27676,"compounds":"ADP + dATP => ATP + dADP"}
{"X":29593,"RHEA_ID":37524,"compounds":"(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine => 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":29594,"RHEA_ID":37525,"compounds":"1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":29595,"RHEA_ID":27679,"DIRECTION":"LR","MASTER_ID":27678,"ecocyc":"DCDPKIN-RXN","metacyc":"DCDPKIN-RXN","compounds":"ATP + dCDP => ADP + dCTP"}
{"X":29596,"RHEA_ID":27680,"compounds":"ADP + dCTP => ATP + dCDP"}
{"X":29597,"RHEA_ID":37528,"compounds":"1-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":29598,"RHEA_ID":37529,"compounds":"1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA"}
{"X":29599,"RHEA_ID":27683,"DIRECTION":"LR","MASTER_ID":27682,"ecocyc":"DTDPKIN-RXN","metacyc":"DTDPKIN-RXN","compounds":"ATP + dTDP => ADP + dTTP"}
{"X":29600,"RHEA_ID":27684,"compounds":"ADP + dTTP => ATP + dTDP"}
{"X":29601,"RHEA_ID":37532,"compounds":"(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA"}
{"X":29602,"RHEA_ID":37533,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine"}
{"X":29603,"RHEA_ID":27687,"DIRECTION":"LR","MASTER_ID":27686,"ecocyc":"GDPKIN-RXN","metacyc":"GDPKIN-RXN","compounds":"ATP + GDP => ADP + GTP"}
{"X":29604,"RHEA_ID":27688,"compounds":"ADP + GTP => ATP + GDP"}
{"X":29605,"RHEA_ID":37536,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA"}
{"X":29606,"RHEA_ID":37537,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine"}
{"X":29607,"RHEA_ID":27691,"DIRECTION":"LR","MASTER_ID":27690,"ecocyc":"DGDPKIN-RXN","metacyc":"DGDPKIN-RXN","compounds":"ATP + dGDP => ADP + dGTP"}
{"X":29608,"RHEA_ID":27692,"compounds":"ADP + dGTP => ATP + dGDP"}
{"X":29609,"RHEA_ID":37540,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA"}
{"X":29610,"RHEA_ID":37541,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine"}
{"X":29611,"RHEA_ID":27695,"DIRECTION":"LR","MASTER_ID":27694,"ecocyc":"DIHYDROXYMETVALDEHYDRAT-RXN","metacyc":"DIHYDROXYMETVALDEHYDRAT-RXN","compounds":"(2R,3R)-2,3-dihydroxy-3-methylpentanoate => (S)-3-methyl-2-oxopentanoate + H2O"}
{"X":29612,"RHEA_ID":27696,"compounds":"(S)-3-methyl-2-oxopentanoate + H2O => (2R,3R)-2,3-dihydroxy-3-methylpentanoate"}
{"X":29613,"RHEA_ID":37544,"DIRECTION":"LR","MASTER_ID":37543,"metacyc":"RXN-8836","compounds":"2-amino-5-chlorophenol + O2 => 2-amino-5-chloromuconate 6-semialdehyde"}
{"X":29614,"RHEA_ID":37545,"compounds":"2-amino-5-chloromuconate 6-semialdehyde => 2-amino-5-chlorophenol + O2"}
{"X":29615,"RHEA_ID":27699,"DIRECTION":"LR","MASTER_ID":27698,"metacyc":"RXNQT-4141","compounds":"GDP-beta-L-galactose + phosphate => beta-L-galactose 1-phosphate + GDP + H(+)"}
{"X":29616,"RHEA_ID":27700,"compounds":"beta-L-galactose 1-phosphate + GDP + H(+) => GDP-beta-L-galactose + phosphate"}
{"X":29617,"RHEA_ID":37548,"DIRECTION":"LR","MASTER_ID":37547,"metacyc":"RXN8J2-136","compounds":"D-glucose 6-phosphate + NAD(+) => 3-dehydro-D-glucose 6-phosphate + H(+) + NADH"}
{"X":29618,"RHEA_ID":37549,"compounds":"3-dehydro-D-glucose 6-phosphate + H(+) + NADH => D-glucose 6-phosphate + NAD(+)"}
{"X":29619,"RHEA_ID":27703,"compounds":"aldehydo-D-galacturonate => keto-D-tagaturonate"}
{"X":29620,"RHEA_ID":27704,"compounds":"keto-D-tagaturonate => aldehydo-D-galacturonate"}
{"X":29621,"RHEA_ID":37552,"compounds":"3-dehydro-D-glucose 6-phosphate + L-glutamate => 2-oxoglutarate + D-kanosamine 6-phosphate"}
{"X":29622,"RHEA_ID":37553,"compounds":"2-oxoglutarate + D-kanosamine 6-phosphate => 3-dehydro-D-glucose 6-phosphate + L-glutamate"}
{"X":29623,"RHEA_ID":27707,"DIRECTION":"LR","MASTER_ID":27706,"metacyc":"RXN-11299","compounds":"ATP + D-alanine + D-serine => ADP + D-alanyl-D-serine + H(+) + phosphate"}
{"X":29624,"RHEA_ID":27708,"compounds":"ADP + D-alanyl-D-serine + H(+) + phosphate => ATP + D-alanine + D-serine"}
{"X":29625,"RHEA_ID":27709,"compounds":"ATP + D-alanine + D-serine <=> ADP + D-alanyl-D-serine + H(+) + phosphate"}
{"X":29626,"RHEA_ID":37557,"compounds":"kanosamine + phosphate => D-kanosamine 6-phosphate + H2O"}
{"X":29627,"RHEA_ID":27711,"DIRECTION":"LR","MASTER_ID":27710,"ecocyc":"GUANOSINEKIN-RXN","metacyc":"GUANOSINEKIN-RXN","compounds":"ATP + guanosine => ADP + GMP + H(+)"}
{"X":29628,"RHEA_ID":27712,"compounds":"ADP + GMP + H(+) => ATP + guanosine"}
{"X":29629,"RHEA_ID":37560,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine => 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":29630,"RHEA_ID":37561,"compounds":"1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine"}
{"X":29631,"RHEA_ID":27715,"DIRECTION":"LR","MASTER_ID":27714,"ecocyc":"RXN-7609","metacyc":"RXN-7609","reactome":"R-HSA-109470.4","compounds":"GMP + H2O => guanosine + phosphate"}
{"X":29632,"RHEA_ID":27715,"DIRECTION":"LR","MASTER_ID":27714,"ecocyc":"RXN-7609","metacyc":"RXN-7609","reactome":"R-HSA-74248.4","compounds":"GMP + H2O => guanosine + phosphate"}
{"X":29633,"RHEA_ID":27715,"DIRECTION":"LR","MASTER_ID":27714,"ecocyc":"RXN-7609","metacyc":"RXN-7609","reactome":"R-HSA-109278.3","compounds":"GMP + H2O => guanosine + phosphate"}
{"X":29634,"RHEA_ID":37565,"compounds":"1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA => (9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine"}
{"X":29635,"RHEA_ID":37566,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine <=> 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":29636,"RHEA_ID":27718,"DIRECTION":"UN","MASTER_ID":27718,"ec":"3.1.3.99","compounds":"H2O + IMP = inosine + phosphate"}
{"X":29637,"RHEA_ID":27719,"DIRECTION":"LR","MASTER_ID":27718,"ecocyc":"RXN-7607","metacyc":"RXN-7607","reactome":"R-HSA-109278.3","compounds":"H2O + IMP => inosine + phosphate"}
{"X":29638,"RHEA_ID":37569,"compounds":"1-acyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA => (9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine"}
{"X":29639,"RHEA_ID":37570,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine <=> 1-acyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA"}
{"X":29640,"RHEA_ID":27722,"DIRECTION":"UN","MASTER_ID":27722,"ec":"2.4.2.53","compounds":"di-trans,octa-cis-undecaprenyl phosphate + UDP-4-deoxy-4-formamido-beta-L-arabinose = 4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + UDP"}
{"X":29641,"RHEA_ID":27723,"DIRECTION":"LR","MASTER_ID":27722,"ecocyc":"RXN0-3521","metacyc":"RXN0-3521","compounds":"di-trans,octa-cis-undecaprenyl phosphate + UDP-4-deoxy-4-formamido-beta-L-arabinose => 4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + UDP"}
{"X":29642,"RHEA_ID":37573,"compounds":"1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine"}
{"X":29643,"RHEA_ID":37574,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine <=> 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA"}
{"X":29644,"RHEA_ID":27726,"compounds":"5-dehydro-4-deoxy-D-glucarate = 2-hydroxy-3-oxopropanoate + pyruvate"}
{"X":29645,"RHEA_ID":27727,"compounds":"5-dehydro-4-deoxy-D-glucarate => 2-hydroxy-3-oxopropanoate + pyruvate"}
{"X":29646,"RHEA_ID":27728,"compounds":"2-hydroxy-3-oxopropanoate + pyruvate => 5-dehydro-4-deoxy-D-glucarate"}
{"X":29647,"RHEA_ID":37578,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine <=> 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":29648,"RHEA_ID":27730,"DIRECTION":"UN","MASTER_ID":27730,"ec":"2.4.2.43","compounds":"4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A (E. coli) = beta-L-Ara4N-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl phosphate"}
{"X":29649,"RHEA_ID":27731,"compounds":"4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A (E. coli) => beta-L-Ara4N-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl phosphate"}
{"X":29650,"RHEA_ID":37581,"compounds":"1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine"}
{"X":29651,"RHEA_ID":27733,"compounds":"4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A (E. coli) <=> beta-L-Ara4N-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl phosphate"}
{"X":29652,"RHEA_ID":27734,"DIRECTION":"UN","MASTER_ID":27734,"ec":"3.5.1.n3","compounds":"4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + H2O = 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + formate"}
{"X":29653,"RHEA_ID":27735,"DIRECTION":"LR","MASTER_ID":27734,"ecocyc":"RXN0-5409","metacyc":"RXN0-5409","compounds":"4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + H2O => 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + formate"}
{"X":29654,"RHEA_ID":37585,"compounds":"6-amino-2-oxohexanoate + H2O2 + NH4(+) => D-lysine + H2O + O2"}
{"X":29655,"RHEA_ID":27738,"DIRECTION":"UN","MASTER_ID":27738,"ec":"2.4.2.1","compounds":"2'-deoxyguanosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + guanine"}
{"X":29656,"RHEA_ID":27739,"compounds":"2'-deoxyguanosine + phosphate => 2-deoxy-alpha-D-ribose 1-phosphate + guanine"}
{"X":29657,"RHEA_ID":27740,"compounds":"2-deoxy-alpha-D-ribose 1-phosphate + guanine => 2'-deoxyguanosine + phosphate"}
{"X":29658,"RHEA_ID":37590,"compounds":"2-oxoglutarate + D-lysine <=> 6-amino-2-oxohexanoate + L-glutamate"}
{"X":29659,"RHEA_ID":27742,"DIRECTION":"UN","MASTER_ID":27742,"ec":"2.4.2.1","compounds":"2'-deoxyadenosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + adenine"}
{"X":29660,"RHEA_ID":27743,"compounds":"2'-deoxyadenosine + phosphate => 2-deoxy-alpha-D-ribose 1-phosphate + adenine"}
{"X":29661,"RHEA_ID":37593,"compounds":"1-(9Z)-octadecenoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + dodecanoyl-CoA"}
{"X":29662,"RHEA_ID":37594,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + dodecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":29663,"RHEA_ID":27746,"compounds":"H(+) + L-cysteine = CO2 + cysteamine"}
{"X":29664,"RHEA_ID":27747,"compounds":"H(+) + L-cysteine => CO2 + cysteamine"}
{"X":29665,"RHEA_ID":27748,"compounds":"CO2 + cysteamine => H(+) + L-cysteine"}
{"X":29666,"RHEA_ID":27749,"compounds":"H(+) + L-cysteine <=> CO2 + cysteamine"}
{"X":29667,"RHEA_ID":27750,"DIRECTION":"UN","MASTER_ID":27750,"ec":"2.4.2.1","compounds":"2'-deoxyinosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine"}
{"X":29668,"RHEA_ID":27751,"compounds":"2'-deoxyinosine + phosphate => 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine"}
{"X":29669,"RHEA_ID":27752,"compounds":"2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine => 2'-deoxyinosine + phosphate"}
{"X":29670,"RHEA_ID":47507,"compounds":"chenodeoxycholate + NADP(+) <=> 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH"}
{"X":29671,"RHEA_ID":37603,"compounds":"(11Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(11Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}
{"X":29672,"RHEA_ID":27754,"DIRECTION":"UN","MASTER_ID":27754,"ec":"4.2.1.130","compounds":"H2O + methylglyoxal = (R)-lactate + H(+)"}
{"X":29673,"RHEA_ID":27755,"DIRECTION":"LR","MASTER_ID":27754,"ecocyc":"GLYOXIII-RXN","metacyc":"GLYOXIII-RXN","compounds":"H2O + methylglyoxal => (R)-lactate + H(+)"}
{"X":29674,"RHEA_ID":27756,"compounds":"(R)-lactate + H(+) => H2O + methylglyoxal"}
{"X":29675,"RHEA_ID":27758,"compounds":"(6S)-5,6,7,8-tetrahydrofolate + glycine + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + CO2 + NADH + NH4(+)"}
{"X":29676,"RHEA_ID":27759,"DIRECTION":"LR","MASTER_ID":27758,"ecocyc":"GCVMULTI-RXN","compounds":"(6S)-5,6,7,8-tetrahydrofolate + glycine + NAD(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + CO2 + NADH + NH4(+)"}
{"X":29677,"RHEA_ID":27760,"compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + CO2 + NADH + NH4(+) => (6S)-5,6,7,8-tetrahydrofolate + glycine + NAD(+)"}
{"X":29678,"RHEA_ID":47516,"compounds":"7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH = isochenodeoxycholate + NAD(+)"}
{"X":29679,"RHEA_ID":27762,"DIRECTION":"UN","MASTER_ID":27762,"ec":"3.6.1.65","compounds":"CTP + H2O = CMP + diphosphate + H(+)"}
{"X":29680,"RHEA_ID":27762,"DIRECTION":"UN","MASTER_ID":27762,"ec":"3.6.1.8","compounds":"CTP + H2O = CMP + diphosphate + H(+)"}
{"X":29681,"RHEA_ID":27762,"DIRECTION":"UN","MASTER_ID":27762,"ec":"3.6.1.9","compounds":"CTP + H2O = CMP + diphosphate + H(+)"}
{"X":29682,"RHEA_ID":27763,"DIRECTION":"LR","MASTER_ID":27762,"ecocyc":"RXN0-383","metacyc":"RXN0-383","compounds":"CTP + H2O => CMP + diphosphate + H(+)"}
{"X":29683,"RHEA_ID":27764,"compounds":"CMP + diphosphate + H(+) => CTP + H2O"}
{"X":29684,"RHEA_ID":37617,"compounds":"1'-[1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol"}
{"X":29685,"RHEA_ID":27770,"DIRECTION":"UN","MASTER_ID":27770,"ec":"2.1.1.222","compounds":"3-(all-trans-octaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = 2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine"}
{"X":29686,"RHEA_ID":37619,"compounds":"(9Z)-octadecenoyl-CoA + 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":29687,"RHEA_ID":27772,"compounds":"2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine => 3-(all-trans-octaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine"}
{"X":29688,"RHEA_ID":37621,"compounds":"1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => (9Z)-octadecenoyl-CoA + 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)"}
{"X":29689,"RHEA_ID":27774,"DIRECTION":"UN","MASTER_ID":27774,"ec":"2.1.1.201","compounds":"2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = 6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine"}
{"X":29690,"RHEA_ID":27775,"DIRECTION":"LR","MASTER_ID":27774,"ecocyc":"2-OCTAPRENYL-METHOXY-BENZOQ-METH-RXN","metacyc":"2-OCTAPRENYL-METHOXY-BENZOQ-METH-RXN","compounds":"2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine => 6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine"}
{"X":29691,"RHEA_ID":27776,"compounds":"6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine => 2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine"}
{"X":29692,"RHEA_ID":27777,"compounds":"2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine <=> 6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine"}
{"X":29693,"RHEA_ID":27778,"DIRECTION":"UN","MASTER_ID":27778,"ec":"4.1.1.98","compounds":"4-hydroxy-3-all-trans-octaprenylbenzoate + H(+) = 2-all-trans-octaprenylphenol + CO2"}
{"X":29694,"RHEA_ID":37627,"compounds":"(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine = 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":29695,"RHEA_ID":27780,"compounds":"2-all-trans-octaprenylphenol + CO2 => 4-hydroxy-3-all-trans-octaprenylbenzoate + H(+)"}
{"X":29696,"RHEA_ID":37629,"compounds":"1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine"}
{"X":29697,"RHEA_ID":27782,"DIRECTION":"UN","MASTER_ID":27782,"ec":"2.5.1.39","compounds":"4-hydroxybenzoate + all-trans-octaprenyl diphosphate = 4-hydroxy-3-all-trans-octaprenylbenzoate + diphosphate"}
{"X":29698,"RHEA_ID":27783,"DIRECTION":"LR","MASTER_ID":27782,"ecocyc":"4OHBENZOATE-OCTAPRENYLTRANSFER-RXN","metacyc":"4OHBENZOATE-OCTAPRENYLTRANSFER-RXN","compounds":"4-hydroxybenzoate + all-trans-octaprenyl diphosphate => 4-hydroxy-3-all-trans-octaprenylbenzoate + diphosphate"}
{"X":29699,"RHEA_ID":27784,"compounds":"4-hydroxy-3-all-trans-octaprenylbenzoate + diphosphate => 4-hydroxybenzoate + all-trans-octaprenyl diphosphate"}
{"X":29700,"RHEA_ID":37633,"compounds":"1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine"}
{"X":29701,"RHEA_ID":27786,"compounds":"2-oxoglutarate + CoA + NAD(+) = CO2 + NADH + succinyl-CoA"}
{"X":29702,"RHEA_ID":37635,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":29703,"RHEA_ID":27788,"compounds":"CO2 + NADH + succinyl-CoA => 2-oxoglutarate + CoA + NAD(+)"}
{"X":29704,"RHEA_ID":37637,"compounds":"1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine"}
{"X":29705,"RHEA_ID":27790,"DIRECTION":"UN","MASTER_ID":27790,"ec":"1.14.13.240","compounds":"2-all-trans-octaprenylphenol + H(+) + NADPH + O2 = 3-(all-trans-octaprenyl)benzene-1,2-diol + H2O + NADP(+)"}
{"X":29706,"RHEA_ID":37639,"compounds":"1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + dodecanoyl-CoA = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}
{"X":29707,"RHEA_ID":27792,"compounds":"3-(all-trans-octaprenyl)benzene-1,2-diol + H2O + NADP(+) => 2-all-trans-octaprenylphenol + H(+) + NADPH + O2"}
{"X":29708,"RHEA_ID":37641,"compounds":"1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + dodecanoyl-CoA"}
{"X":29709,"RHEA_ID":27794,"DIRECTION":"UN","MASTER_ID":27794,"ec":"2.5.1.30","compounds":"(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = all-trans-heptaprenyl diphosphate + 4 diphosphate"}
{"X":29710,"RHEA_ID":37643,"compounds":"(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":29711,"RHEA_ID":27796,"compounds":"all-trans-heptaprenyl diphosphate + 4 diphosphate => (2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate"}
{"X":29712,"RHEA_ID":37645,"compounds":"1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => (9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)"}
{"X":29713,"RHEA_ID":27798,"DIRECTION":"UN","MASTER_ID":27798,"ec":"2.5.1.90","compounds":"(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate = all-trans-octaprenyl diphosphate + 5 diphosphate"}
{"X":29714,"RHEA_ID":27799,"DIRECTION":"LR","MASTER_ID":27798,"ecocyc":"RXN-8992","metacyc":"RXN-8992","compounds":"(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate => all-trans-octaprenyl diphosphate + 5 diphosphate"}
{"X":29715,"RHEA_ID":27800,"compounds":"all-trans-octaprenyl diphosphate + 5 diphosphate => (2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate"}
{"X":29716,"RHEA_ID":37649,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => (9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)"}
{"X":29717,"RHEA_ID":27802,"DIRECTION":"UN","MASTER_ID":27802,"ec":"2.5.1.91","compounds":"(2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate = all-trans-decaprenyl diphosphate + 7 diphosphate"}
{"X":29718,"RHEA_ID":37651,"compounds":"(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":29719,"RHEA_ID":27804,"compounds":"all-trans-decaprenyl diphosphate + 7 diphosphate => (2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate"}
{"X":29720,"RHEA_ID":37653,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)"}
{"X":29721,"RHEA_ID":27806,"compounds":"acetoacetate + acetyl-CoA = acetate + acetoacetyl-CoA"}
{"X":29722,"RHEA_ID":37655,"compounds":"1-tetradecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":29723,"RHEA_ID":27808,"compounds":"acetate + acetoacetyl-CoA => acetoacetate + acetyl-CoA"}
{"X":29724,"RHEA_ID":37657,"compounds":"1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-tetradecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA"}
{"X":29725,"RHEA_ID":27810,"DIRECTION":"UN","MASTER_ID":27810,"ec":"2.5.1.92","compounds":"dimethylallyl diphosphate + 2 isopentenyl diphosphate = (2Z,6Z)-farnesyl diphosphate + 2 diphosphate"}
{"X":29726,"RHEA_ID":37659,"DIRECTION":"UN","MASTER_ID":37659,"ec":"2.3.1.232","compounds":"anthraniloyl-CoA + methanol = CoA + O-methyl anthranilate"}
{"X":29727,"RHEA_ID":27812,"compounds":"(2Z,6Z)-farnesyl diphosphate + 2 diphosphate => dimethylallyl diphosphate + 2 isopentenyl diphosphate"}
{"X":29728,"RHEA_ID":37661,"compounds":"CoA + O-methyl anthranilate => anthraniloyl-CoA + methanol"}
{"X":29729,"RHEA_ID":27814,"compounds":"acetate(in) = acetate(out)"}
{"X":29730,"RHEA_ID":37663,"DIRECTION":"UN","MASTER_ID":37663,"ec":"2.4.1.312","compounds":"3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP"}
{"X":29731,"RHEA_ID":27816,"DIRECTION":"RL","MASTER_ID":27814,"ecocyc":"RXN0-1981","compounds":"acetate(out) => acetate(in)"}
{"X":29732,"RHEA_ID":27817,"compounds":"acetate(in) <=> acetate(out)"}
{"X":29733,"RHEA_ID":27818,"compounds":"2-dehydro-L-idonate + H(+) + NADH = L-idonate + NAD(+)"}
{"X":29734,"RHEA_ID":37667,"DIRECTION":"UN","MASTER_ID":37667,"ec":"2.4.1.313","compounds":"3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP"}
{"X":29735,"RHEA_ID":27820,"compounds":"L-idonate + NAD(+) => 2-dehydro-L-idonate + H(+) + NADH"}
{"X":29736,"RHEA_ID":27821,"compounds":"2-dehydro-L-idonate + H(+) + NADH <=> L-idonate + NAD(+)"}
{"X":29737,"RHEA_ID":27822,"DIRECTION":"UN","MASTER_ID":27822,"ec":"2.5.1.49","compounds":"hydrogen sulfide + O-acetyl-L-homoserine = acetate + L-homocysteine"}
{"X":29738,"RHEA_ID":27823,"compounds":"hydrogen sulfide + O-acetyl-L-homoserine => acetate + L-homocysteine"}
{"X":29739,"RHEA_ID":27824,"compounds":"acetate + L-homocysteine => hydrogen sulfide + O-acetyl-L-homoserine"}
{"X":29740,"RHEA_ID":37677,"compounds":"1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho]-glycerol + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol"}
{"X":29741,"RHEA_ID":27826,"compounds":"hydrogen sulfide + O-succinyl-L-homoserine = L-homocysteine + succinate"}
{"X":29742,"RHEA_ID":37679,"compounds":"1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-dodecanoyl-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":29743,"RHEA_ID":27828,"compounds":"L-homocysteine + succinate => hydrogen sulfide + O-succinyl-L-homoserine"}
{"X":29744,"RHEA_ID":37681,"compounds":"1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-dodecanoyl-sn-glycero-3-phospho]-glycerol + CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA"}
{"X":29745,"RHEA_ID":27830,"DIRECTION":"UN","MASTER_ID":27830,"ec":"4.2.3.51","compounds":"neryl diphosphate = beta-phellandrene + diphosphate"}
{"X":29746,"RHEA_ID":27831,"DIRECTION":"LR","MASTER_ID":27830,"metacyc":"RXN-8584","compounds":"neryl diphosphate => beta-phellandrene + diphosphate"}
{"X":29747,"RHEA_ID":37684,"compounds":"1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA => 1'-[1-acyl-2-dodecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":29748,"RHEA_ID":37685,"compounds":"1'-[1-acyl-2-dodecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA => 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA"}
{"X":29749,"RHEA_ID":27834,"DIRECTION":"UN","MASTER_ID":27834,"ec":"1.3.5.4","compounds":"a menaquinone + succinate = a menaquinol + fumarate"}
{"X":29750,"RHEA_ID":27835,"compounds":"a menaquinone + succinate => a menaquinol + fumarate"}
{"X":29751,"RHEA_ID":37688,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol => 1'-[1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":29752,"RHEA_ID":27837,"compounds":"a menaquinone + succinate <=> a menaquinol + fumarate"}
{"X":29753,"RHEA_ID":27838,"DIRECTION":"UN","MASTER_ID":27838,"ec":"1.14.12.22","compounds":"9H-carbazole + H(+) + NADH + O2 = 2'-aminobiphenyl-2,3-diol + NAD(+)"}
{"X":29754,"RHEA_ID":27839,"DIRECTION":"LR","MASTER_ID":27838,"metacyc":"RXN-11511","compounds":"9H-carbazole + H(+) + NADH + O2 => 2'-aminobiphenyl-2,3-diol + NAD(+)"}
{"X":29755,"RHEA_ID":37692,"compounds":"1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA => 1'-[1-acyl-2-hexadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":29756,"RHEA_ID":37693,"compounds":"1'-[1-acyl-2-hexadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA => 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA"}
{"X":29757,"RHEA_ID":27842,"DIRECTION":"UN","MASTER_ID":27842,"ec":"1.14.12.22","compounds":"9H-carbazole + H(+) + NADPH + O2 = 2'-aminobiphenyl-2,3-diol + NADP(+)"}
{"X":29758,"RHEA_ID":27843,"DIRECTION":"LR","MASTER_ID":27842,"metacyc":"RXN-11511","compounds":"9H-carbazole + H(+) + NADPH + O2 => 2'-aminobiphenyl-2,3-diol + NADP(+)"}
{"X":29759,"RHEA_ID":27844,"compounds":"2'-aminobiphenyl-2,3-diol + NADP(+) => 9H-carbazole + H(+) + NADPH + O2"}
{"X":29760,"RHEA_ID":37697,"compounds":"1'-[1-acyl-2-octadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA => 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octadecanoyl-CoA"}
{"X":29761,"RHEA_ID":27846,"DIRECTION":"UN","MASTER_ID":27846,"ec":"1.14.13.127","compounds":"(2E)-3-(3-hydroxyphenyl)prop-2-enoate + H(+) + NADH + O2 = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD(+)"}
{"X":29762,"RHEA_ID":27847,"DIRECTION":"LR","MASTER_ID":27846,"ecocyc":"RXN-10040","metacyc":"RXN-10040","compounds":"(2E)-3-(3-hydroxyphenyl)prop-2-enoate + H(+) + NADH + O2 => (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD(+)"}
{"X":29763,"RHEA_ID":37700,"compounds":"1-O-octadecyl-sn-glycero-3-phosphocholine + acetyl-CoA => 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA"}
{"X":29764,"RHEA_ID":37701,"compounds":"1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA => 1-O-octadecyl-sn-glycero-3-phosphocholine + acetyl-CoA"}
{"X":29765,"RHEA_ID":27850,"DIRECTION":"UN","MASTER_ID":27850,"ec":"2.3.1.192","compounds":"glycine + phenylacetyl-CoA = CoA + H(+) + phenylacetylglycine"}
{"X":29766,"RHEA_ID":27851,"DIRECTION":"LR","MASTER_ID":27850,"metacyc":"RXN-10821","compounds":"glycine + phenylacetyl-CoA => CoA + H(+) + phenylacetylglycine"}
{"X":29767,"RHEA_ID":37704,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA => 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA"}
{"X":29768,"RHEA_ID":37705,"compounds":"1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA"}
{"X":29769,"RHEA_ID":27854,"DIRECTION":"UN","MASTER_ID":27854,"ec":"2.5.1.93","compounds":"(2E)-geranyl diphosphate + 4-hydroxybenzoate = 3-geranyl-4-hydroxybenzoate + diphosphate"}
{"X":29770,"RHEA_ID":27855,"DIRECTION":"LR","MASTER_ID":27854,"metacyc":"RXN-8920","compounds":"(2E)-geranyl diphosphate + 4-hydroxybenzoate => 3-geranyl-4-hydroxybenzoate + diphosphate"}
{"X":29771,"RHEA_ID":27856,"compounds":"3-geranyl-4-hydroxybenzoate + diphosphate => (2E)-geranyl diphosphate + 4-hydroxybenzoate"}
{"X":29772,"RHEA_ID":37709,"compounds":"1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA => 1-octadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA"}
{"X":29773,"RHEA_ID":27858,"DIRECTION":"UN","MASTER_ID":27858,"ec":"3.1.4.16","compounds":"2',3'-cyclic GMP + H2O = 3'-GMP + H(+)"}
{"X":29774,"RHEA_ID":27859,"DIRECTION":"LR","MASTER_ID":27858,"ecocyc":"RXN-14064","metacyc":"RXN-14064","compounds":"2',3'-cyclic GMP + H2O => 3'-GMP + H(+)"}
{"X":29775,"RHEA_ID":37712,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + acetyl-CoA => 1-O-(1Z)-alkenyl-2-acetyl-sn-glycero-3-phosphocholine + CoA"}
{"X":29776,"RHEA_ID":37713,"compounds":"1-O-(1Z)-alkenyl-2-acetyl-sn-glycero-3-phosphocholine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + acetyl-CoA"}
{"X":29777,"RHEA_ID":27862,"compounds":"3'-GMP + H2O = guanosine + phosphate"}
{"X":29778,"RHEA_ID":27863,"compounds":"3'-GMP + H2O => guanosine + phosphate"}
{"X":29779,"RHEA_ID":27864,"compounds":"guanosine + phosphate => 3'-GMP + H2O"}
{"X":29780,"RHEA_ID":37717,"compounds":"1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-alkyl-sn-glycero-3-phosphocholine"}
{"X":29781,"RHEA_ID":27866,"compounds":"(2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate + H2O = (R)-glycerate + alpha-D-mannose 6-phosphate"}
{"X":29782,"RHEA_ID":27867,"DIRECTION":"LR","MASTER_ID":27866,"ecocyc":"RXN0-5216","metacyc":"RXN0-5216","compounds":"(2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate + H2O => (R)-glycerate + alpha-D-mannose 6-phosphate"}
{"X":29783,"RHEA_ID":27868,"compounds":"(R)-glycerate + alpha-D-mannose 6-phosphate => (2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate + H2O"}
{"X":29784,"RHEA_ID":27869,"compounds":"(2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate + H2O <=> (R)-glycerate + alpha-D-mannose 6-phosphate"}
{"X":29785,"RHEA_ID":27870,"DIRECTION":"UN","MASTER_ID":27870,"ec":"3.7.1.13","compounds":"(2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + anthranilate + H(+)"}
{"X":29786,"RHEA_ID":27871,"DIRECTION":"LR","MASTER_ID":27870,"metacyc":"RXN-11543","compounds":"(2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O => (2E)-2-hydroxypenta-2,4-dienoate + anthranilate + H(+)"}
{"X":29787,"RHEA_ID":37724,"compounds":"(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine => 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":29788,"RHEA_ID":37725,"compounds":"1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphocholine + CoA => (9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine"}
{"X":29789,"RHEA_ID":27874,"DIRECTION":"UN","MASTER_ID":27874,"ec":"4.2.99.21","compounds":"isochorismate = pyruvate + salicylate"}
{"X":29790,"RHEA_ID":27875,"DIRECTION":"LR","MASTER_ID":27874,"metacyc":"RXN-1981","compounds":"isochorismate => pyruvate + salicylate"}
{"X":29791,"RHEA_ID":37728,"compounds":"(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine => 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":29792,"RHEA_ID":37729,"compounds":"1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine"}
{"X":29793,"RHEA_ID":27878,"DIRECTION":"UN","MASTER_ID":27878,"ec":"3.1.4.16","compounds":"2',3'-cyclic UMP + H2O = 3'-UMP + H(+)"}
{"X":29794,"RHEA_ID":27879,"DIRECTION":"LR","MASTER_ID":27878,"ecocyc":"RXN-14091","metacyc":"RXN-14091","compounds":"2',3'-cyclic UMP + H2O => 3'-UMP + H(+)"}
{"X":29795,"RHEA_ID":37732,"compounds":"(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine => 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":29796,"RHEA_ID":37733,"compounds":"1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine"}
{"X":29797,"RHEA_ID":27882,"DIRECTION":"UN","MASTER_ID":27882,"ec":"3.1.4.16","compounds":"2',3'-cyclic CMP + H2O = 3'-CMP + H(+)"}
{"X":29798,"RHEA_ID":27883,"DIRECTION":"LR","MASTER_ID":27882,"ecocyc":"RXN-14112","metacyc":"RXN-14112","compounds":"2',3'-cyclic CMP + H2O => 3'-CMP + H(+)"}
{"X":29799,"RHEA_ID":37736,"compounds":"(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine => 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA"}
{"X":29800,"RHEA_ID":37737,"compounds":"1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA => (9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine"}
{"X":29801,"RHEA_ID":27886,"DIRECTION":"UN","MASTER_ID":27886,"ec":"3.1.4.16","compounds":"2',3'-cyclic AMP + H2O = 3'-AMP + H(+)"}
{"X":29802,"RHEA_ID":27887,"DIRECTION":"LR","MASTER_ID":27886,"ecocyc":"RXN-14113","metacyc":"RXN-14113","compounds":"2',3'-cyclic AMP + H2O => 3'-AMP + H(+)"}
{"X":29803,"RHEA_ID":37740,"compounds":"(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine => 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoserine + CoA"}
{"X":29804,"RHEA_ID":37741,"compounds":"1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoserine + CoA => (9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine"}
{"X":29805,"RHEA_ID":27890,"compounds":"3'-UMP + H2O = phosphate + uridine"}
{"X":29806,"RHEA_ID":27891,"DIRECTION":"LR","MASTER_ID":27890,"ecocyc":"RXN-14115","metacyc":"RXN-14115","compounds":"3'-UMP + H2O => phosphate + uridine"}
{"X":29807,"RHEA_ID":37744,"DIRECTION":"LR","MASTER_ID":37743,"ecocyc":"RXN-16937","metacyc":"RXN-16937","compounds":"dimethylallyl phosphate + FMNH2 => phosphate + prenyl-FMNH2"}
{"X":29808,"RHEA_ID":37745,"compounds":"phosphate + prenyl-FMNH2 => dimethylallyl phosphate + FMNH2"}
{"X":29809,"RHEA_ID":27894,"compounds":"3'-CMP + H2O = cytidine + phosphate"}
{"X":29810,"RHEA_ID":27895,"DIRECTION":"LR","MASTER_ID":27894,"ecocyc":"RXN-14522","metacyc":"RXN-14522","compounds":"3'-CMP + H2O => cytidine + phosphate"}
{"X":29811,"RHEA_ID":37748,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-octadecyl-sn-glycero-3-phosphocholine => 1-O-octadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":29812,"RHEA_ID":37749,"compounds":"1-O-octadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-octadecyl-sn-glycero-3-phosphocholine"}
{"X":29813,"RHEA_ID":27898,"compounds":"3'-AMP + H2O = adenosine + phosphate"}
{"X":29814,"RHEA_ID":27899,"DIRECTION":"LR","MASTER_ID":27898,"ecocyc":"RXN-14126","metacyc":"RXN-14126","compounds":"3'-AMP + H2O => adenosine + phosphate"}
{"X":29815,"RHEA_ID":37752,"DIRECTION":"LR","MASTER_ID":37751,"metacyc":"RXN-8977","compounds":"2-methyl-trans-aconitate => 2-methyl-cis-aconitate"}
{"X":29816,"RHEA_ID":37753,"compounds":"2-methyl-cis-aconitate => 2-methyl-trans-aconitate"}
{"X":29817,"RHEA_ID":27902,"DIRECTION":"UN","MASTER_ID":27902,"ec":"1.17.5.2","compounds":"caffeine + H2O + ubiquinone-0 = 1,3,7-trimethylurate + ubiquinol-0"}
{"X":29818,"RHEA_ID":27903,"compounds":"caffeine + H2O + ubiquinone-0 => 1,3,7-trimethylurate + ubiquinol-0"}
{"X":29819,"RHEA_ID":37756,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA => 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":29820,"RHEA_ID":27905,"compounds":"caffeine + H2O + ubiquinone-0 <=> 1,3,7-trimethylurate + ubiquinol-0"}
{"X":29821,"RHEA_ID":27906,"DIRECTION":"UN","MASTER_ID":27906,"ec":"1.3.1.86","compounds":"butanoyl-CoA + NADP(+) = (2E)-butenoyl-CoA + H(+) + NADPH"}
{"X":29822,"RHEA_ID":27907,"compounds":"butanoyl-CoA + NADP(+) => (2E)-butenoyl-CoA + H(+) + NADPH"}
{"X":29823,"RHEA_ID":37760,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA => 1-O-(1Z)-alkenyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":29824,"RHEA_ID":37761,"compounds":"1-O-(1Z)-alkenyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA"}
{"X":29825,"RHEA_ID":27910,"compounds":"D-gluconate + NAD(+) = 2-dehydro-D-gluconate + H(+) + NADH"}
{"X":29826,"RHEA_ID":27911,"compounds":"D-gluconate + NAD(+) => 2-dehydro-D-gluconate + H(+) + NADH"}
{"X":29827,"RHEA_ID":37764,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octanoyl-CoA => 1-O-(1Z)-alkenyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":29828,"RHEA_ID":27913,"compounds":"D-gluconate + NAD(+) <=> 2-dehydro-D-gluconate + H(+) + NADH"}
{"X":29829,"RHEA_ID":27914,"compounds":"4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H2O = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + H(+) + phosphate"}
{"X":29830,"RHEA_ID":27915,"DIRECTION":"LR","MASTER_ID":27914,"ecocyc":"RXN0-3543","metacyc":"RXN0-3543","compounds":"4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H2O => 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + H(+) + phosphate"}
{"X":29831,"RHEA_ID":27916,"compounds":"4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + H(+) + phosphate => 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H2O"}
{"X":29832,"RHEA_ID":27917,"compounds":"4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H2O <=> 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + H(+) + phosphate"}
{"X":29833,"RHEA_ID":27918,"compounds":"H2O + NADP(+) + propanal = 2 H(+) + NADPH + propanoate"}
{"X":29834,"RHEA_ID":27919,"DIRECTION":"LR","MASTER_ID":27918,"metacyc":"RXN-8946","compounds":"H2O + NADP(+) + propanal => 2 H(+) + NADPH + propanoate"}
{"X":29835,"RHEA_ID":37772,"compounds":"a 1-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA => 1-acyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":29836,"RHEA_ID":27921,"compounds":"H2O + NADP(+) + propanal <=> 2 H(+) + NADPH + propanoate"}
{"X":29837,"RHEA_ID":27922,"compounds":"5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+) + phosphate"}
{"X":29838,"RHEA_ID":27923,"compounds":"5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O + O2 => 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+) + phosphate"}
{"X":29839,"RHEA_ID":27924,"compounds":"4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+) + phosphate => 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O + O2"}
{"X":29840,"RHEA_ID":27925,"compounds":"5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O + O2 <=> 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+) + phosphate"}
{"X":29841,"RHEA_ID":27926,"compounds":"UMP(in) = UMP(out)"}
{"X":29842,"RHEA_ID":27927,"compounds":"UMP(in) => UMP(out)"}
{"X":29843,"RHEA_ID":37780,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":29844,"RHEA_ID":27929,"compounds":"UMP(in) <=> UMP(out)"}
{"X":29845,"RHEA_ID":27930,"DIRECTION":"UN","MASTER_ID":27930,"ec":"6.3.2.36","compounds":"(R)-4-phosphopantoate + ATP + beta-alanine = (R)-4'-phosphopantothenate + AMP + diphosphate + H(+)"}
{"X":29846,"RHEA_ID":27931,"DIRECTION":"LR","MASTER_ID":27930,"metacyc":"RXN-11781","compounds":"(R)-4-phosphopantoate + ATP + beta-alanine => (R)-4'-phosphopantothenate + AMP + diphosphate + H(+)"}
{"X":29847,"RHEA_ID":27932,"compounds":"(R)-4'-phosphopantothenate + AMP + diphosphate + H(+) => (R)-4-phosphopantoate + ATP + beta-alanine"}
{"X":29848,"RHEA_ID":37785,"compounds":"1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine"}
{"X":29849,"RHEA_ID":27934,"DIRECTION":"UN","MASTER_ID":27934,"ec":"4.1.3.41","compounds":"(3S)-3-hydroxy-D-aspartate = glycine + glyoxylate"}
{"X":29850,"RHEA_ID":27935,"compounds":"(3S)-3-hydroxy-D-aspartate => glycine + glyoxylate"}
{"X":29851,"RHEA_ID":37788,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":29852,"RHEA_ID":27938,"DIRECTION":"UN","MASTER_ID":27938,"ec":"4.1.3.41","compounds":"(3R)-3-hydroxy-D-aspartate = glycine + glyoxylate"}
{"X":29853,"RHEA_ID":27939,"compounds":"(3R)-3-hydroxy-D-aspartate => glycine + glyoxylate"}
{"X":29854,"RHEA_ID":37792,"DIRECTION":"LR","MASTER_ID":37791,"metacyc":"RXN-14688","compounds":"aclacinomycin A + O2 => aclacinomycin Y + H2O2"}
{"X":29855,"RHEA_ID":27942,"DIRECTION":"UN","MASTER_ID":27942,"ec":"4.3.1.27","compounds":"(3R)-3-hydroxy-D-aspartate = NH4(+) + oxaloacetate"}
{"X":29856,"RHEA_ID":27943,"compounds":"(3R)-3-hydroxy-D-aspartate => NH4(+) + oxaloacetate"}
{"X":29857,"RHEA_ID":37796,"DIRECTION":"LR","MASTER_ID":37795,"metacyc":"RXN-14690","compounds":"2 H(+) + 2 NADPH + O2 => 2 H2O + 2 NADP(+)"}
{"X":29858,"RHEA_ID":37797,"compounds":"2 H2O + 2 NADP(+) => 2 H(+) + 2 NADPH + O2"}
{"X":29859,"RHEA_ID":27946,"compounds":"dopamine + H2O + O2 = 3,4-dihydroxyphenylacetaldehyde + H2O2 + NH4(+)"}
{"X":29860,"RHEA_ID":27947,"DIRECTION":"LR","MASTER_ID":27946,"metacyc":"RXN6666-4","compounds":"dopamine + H2O + O2 => 3,4-dihydroxyphenylacetaldehyde + H2O2 + NH4(+)"}
{"X":29861,"RHEA_ID":37799,"DIRECTION":"UN","MASTER_ID":37799,"ec":"1.6.3.4","compounds":"2 H(+) + 2 NADH + O2 = 2 H2O + 2 NAD(+)"}
{"X":29862,"RHEA_ID":37800,"DIRECTION":"LR","MASTER_ID":37799,"metacyc":"RXN-14690","compounds":"2 H(+) + 2 NADH + O2 => 2 H2O + 2 NAD(+)"}
{"X":29863,"RHEA_ID":27950,"compounds":"L-phenylalanine(in) = L-phenylalanine(out)"}
{"X":29864,"RHEA_ID":27951,"DIRECTION":"LR","MASTER_ID":27950,"reactome":"R-HSA-352107.1","compounds":"L-phenylalanine(in) => L-phenylalanine(out)"}
{"X":29865,"RHEA_ID":27951,"DIRECTION":"LR","MASTER_ID":27950,"reactome":"R-HSA-352191.2","compounds":"L-phenylalanine(in) => L-phenylalanine(out)"}
{"X":29866,"RHEA_ID":27951,"DIRECTION":"LR","MASTER_ID":27950,"reactome":"R-HSA-352103.1","compounds":"L-phenylalanine(in) => L-phenylalanine(out)"}
{"X":29867,"RHEA_ID":27951,"DIRECTION":"LR","MASTER_ID":27950,"reactome":"R-HSA-352232.3","compounds":"L-phenylalanine(in) => L-phenylalanine(out)"}
{"X":29868,"RHEA_ID":37806,"compounds":"a 1-acyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":29869,"RHEA_ID":27953,"compounds":"L-phenylalanine(in) <=> L-phenylalanine(out)"}
{"X":29870,"RHEA_ID":27954,"DIRECTION":"UN","MASTER_ID":27954,"ec":"4.2.3.74","compounds":"(2E,6E)-farnesyl diphosphate + H2O = diphosphate + presilphiperfolan-8beta-ol"}
{"X":29871,"RHEA_ID":27955,"DIRECTION":"LR","MASTER_ID":27954,"metacyc":"RXN-10640","compounds":"(2E,6E)-farnesyl diphosphate + H2O => diphosphate + presilphiperfolan-8beta-ol"}
{"X":29872,"RHEA_ID":37810,"compounds":"1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA <=> 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":29873,"RHEA_ID":37811,"compounds":"1-O-hexadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":29874,"RHEA_ID":27958,"DIRECTION":"UN","MASTER_ID":27958,"ec":"3.2.2.8","compounds":"cytidine + H2O = cytosine + D-ribose"}
{"X":29875,"RHEA_ID":27959,"DIRECTION":"LR","MASTER_ID":27958,"ecocyc":"RXN0-361","metacyc":"RXN0-361","compounds":"cytidine + H2O => cytosine + D-ribose"}
{"X":29876,"RHEA_ID":37814,"compounds":"1-O-hexadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":29877,"RHEA_ID":37815,"DIRECTION":"UN","MASTER_ID":37815,"ec":"1.14.11.44","compounds":"(R)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2 = 2-methyl-4-chlorophenol + CO2 + pyruvate + succinate"}
{"X":29878,"RHEA_ID":27962,"DIRECTION":"UN","MASTER_ID":27962,"ec":"1.1.5.n1","compounds":"myo-inositol + pyrroloquinoline quinone = H(+) + pyrroloquinoline quinol + scyllo-inosose"}
{"X":29879,"RHEA_ID":27963,"compounds":"myo-inositol + pyrroloquinoline quinone => H(+) + pyrroloquinoline quinol + scyllo-inosose"}
{"X":29880,"RHEA_ID":47721,"DIRECTION":"LR","MASTER_ID":47720,"ecocyc":"RXN0-6708","metacyc":"RXN0-6708","compounds":"H(+) + H2O + isoguanine => NH4(+) + xanthine"}
{"X":29881,"RHEA_ID":27965,"compounds":"myo-inositol + pyrroloquinoline quinone <=> H(+) + pyrroloquinoline quinol + scyllo-inosose"}
{"X":29882,"RHEA_ID":27966,"DIRECTION":"UN","MASTER_ID":27966,"ec":"4.1.2.50","compounds":"7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate"}
{"X":29883,"RHEA_ID":27967,"DIRECTION":"LR","MASTER_ID":27966,"ecocyc":"RXN0-5507","metacyc":"RXN0-5507","compounds":"7,8-dihydroneopterin 3'-triphosphate + H2O => 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate"}
{"X":29884,"RHEA_ID":37822,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":29885,"RHEA_ID":37823,"DIRECTION":"UN","MASTER_ID":37823,"ec":"1.14.11.44","compounds":"(R)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 = 2,4-dichlorophenol + CO2 + pyruvate + succinate"}
{"X":29886,"RHEA_ID":27970,"compounds":"alpha-maltotriose + H2O = alpha-D-glucose + beta-maltose"}
{"X":29887,"RHEA_ID":27971,"DIRECTION":"LR","MASTER_ID":27970,"ecocyc":"RXN0-5183","metacyc":"RXN0-5183","compounds":"alpha-maltotriose + H2O => alpha-D-glucose + beta-maltose"}
{"X":29888,"RHEA_ID":47729,"compounds":"(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP-alpha-D-mannose => (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + GDP + H(+)"}
{"X":29889,"RHEA_ID":27973,"compounds":"alpha-maltotriose + H2O <=> alpha-D-glucose + beta-maltose"}
{"X":29890,"RHEA_ID":27974,"DIRECTION":"UN","MASTER_ID":27974,"ec":"4.3.99.3","compounds":"6-carboxy-5,6,7,8-tetrahydropterin + H(+) = 7-carboxy-7-deazaguanine + NH4(+)"}
{"X":29891,"RHEA_ID":27975,"DIRECTION":"LR","MASTER_ID":27974,"metacyc":"RXN0-6575","compounds":"6-carboxy-5,6,7,8-tetrahydropterin + H(+) => 7-carboxy-7-deazaguanine + NH4(+)"}
{"X":29892,"RHEA_ID":27976,"compounds":"7-carboxy-7-deazaguanine + NH4(+) => 6-carboxy-5,6,7,8-tetrahydropterin + H(+)"}
{"X":29893,"RHEA_ID":27977,"compounds":"6-carboxy-5,6,7,8-tetrahydropterin + H(+) <=> 7-carboxy-7-deazaguanine + NH4(+)"}
{"X":29894,"RHEA_ID":27978,"compounds":"GDP-alpha-D-mannose + H2O = alpha-D-mannose 1-phosphate + GMP + 2 H(+)"}
{"X":29895,"RHEA_ID":27979,"compounds":"GDP-alpha-D-mannose + H2O => alpha-D-mannose 1-phosphate + GMP + 2 H(+)"}
{"X":29896,"RHEA_ID":47737,"compounds":"cytidine(1404) in 16S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(1404) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":29897,"RHEA_ID":37835,"DIRECTION":"UN","MASTER_ID":37835,"ec":"1.14.13.180","compounds":"aklavinone + H(+) + NADPH + O2 = epsilon-rhodomycinone + H2O + NADP(+)"}
{"X":29898,"RHEA_ID":27982,"DIRECTION":"UN","MASTER_ID":27982,"ec":"6.3.4.20","compounds":"7-carboxy-7-deazaguanine + ATP + NH4(+) = 7-cyano-7-deazaguanine + ADP + H(+) + H2O + phosphate"}
{"X":29899,"RHEA_ID":27983,"DIRECTION":"LR","MASTER_ID":27982,"ecocyc":"RXN-12093","metacyc":"RXN-12093","compounds":"7-carboxy-7-deazaguanine + ATP + NH4(+) => 7-cyano-7-deazaguanine + ADP + H(+) + H2O + phosphate"}
{"X":29900,"RHEA_ID":47741,"DIRECTION":"LR","MASTER_ID":47740,"metacyc":"RXN-7568","compounds":"1,4-dioxo-2-naphthoate + H(+) + phytyl diphosphate => CO2 + demethylphylloquinone + diphosphate"}
{"X":29901,"RHEA_ID":27985,"compounds":"7-carboxy-7-deazaguanine + ATP + NH4(+) <=> 7-cyano-7-deazaguanine + ADP + H(+) + H2O + phosphate"}
{"X":29902,"RHEA_ID":27986,"compounds":"hydroxyacetone + NADP(+) = H(+) + methylglyoxal + NADPH"}
{"X":29903,"RHEA_ID":27987,"compounds":"hydroxyacetone + NADP(+) => H(+) + methylglyoxal + NADPH"}
{"X":29904,"RHEA_ID":37842,"compounds":"1-O-octadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-O-octadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":29905,"RHEA_ID":27990,"compounds":"1-deoxy-D-xylulose + ATP = 1-deoxy-D-xylulose 5-phosphate + ADP + H(+)"}
{"X":29906,"RHEA_ID":27991,"DIRECTION":"LR","MASTER_ID":27990,"ecocyc":"RXN0-382","metacyc":"RXN0-382","compounds":"1-deoxy-D-xylulose + ATP => 1-deoxy-D-xylulose 5-phosphate + ADP + H(+)"}
{"X":29907,"RHEA_ID":37846,"compounds":"1-eicosanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-eicosanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":29908,"RHEA_ID":27993,"compounds":"1-deoxy-D-xylulose + ATP <=> 1-deoxy-D-xylulose 5-phosphate + ADP + H(+)"}
{"X":29909,"RHEA_ID":27994,"compounds":"H2O + xanthosine = D-ribose + xanthine"}
{"X":29910,"RHEA_ID":27995,"DIRECTION":"LR","MASTER_ID":27994,"ecocyc":"RXN0-363","metacyc":"RXN0-363","compounds":"H2O + xanthosine => D-ribose + xanthine"}
{"X":29911,"RHEA_ID":47753,"DIRECTION":"LR","MASTER_ID":47752,"metacyc":"RXN-16722","compounds":"5-hydroxy-3-methyl-L-tyrosine + S-adenosyl-L-methionine => 5-hydroxy-3-methyl-O-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine"}
{"X":29912,"RHEA_ID":37851,"DIRECTION":"UN","MASTER_ID":37851,"ec":"1.14.13.181","compounds":"13-deoxydaunorubicin + H(+) + NADPH + O2 = 13-dihydrodaunorubicin + H2O + NADP(+)"}
{"X":29913,"RHEA_ID":27998,"compounds":"H2O + thiamine diphosphate = H(+) + phosphate + thiamine phosphate"}
{"X":29914,"RHEA_ID":27999,"compounds":"H2O + thiamine diphosphate => H(+) + phosphate + thiamine phosphate"}
{"X":29915,"RHEA_ID":47757,"compounds":"guanosine(1370) in 16S rRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine(1370) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":29916,"RHEA_ID":37855,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + hexanoyl-CoA = 1-hexadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":29917,"RHEA_ID":28002,"compounds":"beta-D-fructose 6-phosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone"}
{"X":29918,"RHEA_ID":28003,"compounds":"beta-D-fructose 6-phosphate => D-glyceraldehyde 3-phosphate + dihydroxyacetone"}
{"X":29919,"RHEA_ID":37858,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + hexanoyl-CoA <=> 1-hexadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":29920,"RHEA_ID":28005,"DIRECTION":"BI","MASTER_ID":28002,"ecocyc":"RXN0-313","metacyc":"RXN0-313","compounds":"beta-D-fructose 6-phosphate <=> D-glyceraldehyde 3-phosphate + dihydroxyacetone"}
{"X":29921,"RHEA_ID":28006,"compounds":"H2O + N(alpha)-methyl-L-tryptophan + O2 = formaldehyde + H2O2 + L-tryptophan"}
{"X":29922,"RHEA_ID":28007,"DIRECTION":"LR","MASTER_ID":28006,"ecocyc":"RXN0-301","metacyc":"RXN0-301","compounds":"H2O + N(alpha)-methyl-L-tryptophan + O2 => formaldehyde + H2O2 + L-tryptophan"}
{"X":29923,"RHEA_ID":37862,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + octanoyl-CoA <=> 1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":29924,"RHEA_ID":28009,"compounds":"H2O + N(alpha)-methyl-L-tryptophan + O2 <=> formaldehyde + H2O2 + L-tryptophan"}
{"X":29925,"RHEA_ID":28010,"compounds":"propanoyl-CoA + succinate = propanoate + succinyl-CoA"}
{"X":29926,"RHEA_ID":28011,"compounds":"propanoyl-CoA + succinate => propanoate + succinyl-CoA"}
{"X":29927,"RHEA_ID":37866,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + decanoyl-CoA <=> 1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":29928,"RHEA_ID":37867,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + tetradecanoyl-CoA = 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":29929,"RHEA_ID":28014,"DIRECTION":"UN","MASTER_ID":28014,"ec":"2.1.1.n4","compounds":"S-adenosyl-L-methionine + thiocyanate = methyl thiocyanate + S-adenosyl-L-homocysteine"}
{"X":29930,"RHEA_ID":28015,"DIRECTION":"LR","MASTER_ID":28014,"metacyc":"RXN-12189","compounds":"S-adenosyl-L-methionine + thiocyanate => methyl thiocyanate + S-adenosyl-L-homocysteine"}
{"X":29931,"RHEA_ID":37870,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + tetradecanoyl-CoA <=> 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":29932,"RHEA_ID":28017,"compounds":"S-adenosyl-L-methionine + thiocyanate <=> methyl thiocyanate + S-adenosyl-L-homocysteine"}
{"X":29933,"RHEA_ID":28018,"compounds":"enterobactin + 3 H2O = 2 H(+) + 3 N-(2,3-dihydroxybenzoyl)-L-serine"}
{"X":29934,"RHEA_ID":28019,"DIRECTION":"LR","MASTER_ID":28018,"ecocyc":"RXN0-1661","metacyc":"RXN0-1661","compounds":"enterobactin + 3 H2O => 2 H(+) + 3 N-(2,3-dihydroxybenzoyl)-L-serine"}
{"X":29935,"RHEA_ID":28020,"compounds":"2 H(+) + 3 N-(2,3-dihydroxybenzoyl)-L-serine => enterobactin + 3 H2O"}
{"X":29936,"RHEA_ID":28021,"compounds":"enterobactin + 3 H2O <=> 2 H(+) + 3 N-(2,3-dihydroxybenzoyl)-L-serine"}
{"X":29937,"RHEA_ID":28022,"compounds":"ATP + holo-[ACP] + octanoate = AMP + diphosphate + octanoyl-[ACP]"}
{"X":29938,"RHEA_ID":28023,"DIRECTION":"LR","MASTER_ID":28022,"ecocyc":"RXN-5741","metacyc":"RXN-5741","compounds":"ATP + holo-[ACP] + octanoate => AMP + diphosphate + octanoyl-[ACP]"}
{"X":29939,"RHEA_ID":47781,"compounds":"a cytidine in 25S rRNA + S-adenosyl-L-methionine => a 5-methylcytidine in 25S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":29940,"RHEA_ID":28025,"compounds":"ATP + holo-[ACP] + octanoate <=> AMP + diphosphate + octanoyl-[ACP]"}
{"X":29941,"RHEA_ID":28026,"DIRECTION":"UN","MASTER_ID":28026,"ec":"1.17.4.1","compounds":"[thioredoxin]-disulfide + dUDP + H2O = [thioredoxin]-dithiol + UDP"}
{"X":29942,"RHEA_ID":28027,"compounds":"[thioredoxin]-disulfide + dUDP + H2O => [thioredoxin]-dithiol + UDP"}
{"X":29943,"RHEA_ID":28028,"DIRECTION":"RL","MASTER_ID":28026,"ecocyc":"UDPREDUCT-RXN","metacyc":"UDPREDUCT-RXN","compounds":"[thioredoxin]-dithiol + UDP => [thioredoxin]-disulfide + dUDP + H2O"}
{"X":29944,"RHEA_ID":37883,"DIRECTION":"UN","MASTER_ID":37883,"ec":"2.8.3.19","compounds":"acetyl-CoA + oxalate = acetate + oxalyl-CoA"}
{"X":29945,"RHEA_ID":28030,"DIRECTION":"UN","MASTER_ID":28030,"ec":"1.17.4.1","compounds":"[thioredoxin]-disulfide + dGDP + H2O = [thioredoxin]-dithiol + GDP"}
{"X":29946,"RHEA_ID":28031,"compounds":"[thioredoxin]-disulfide + dGDP + H2O => [thioredoxin]-dithiol + GDP"}
{"X":29947,"RHEA_ID":47789,"compounds":"a cytidine in 28S rRNA + S-adenosyl-L-methionine => a 5-methylcytidine in 28S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":29948,"RHEA_ID":37887,"DIRECTION":"UN","MASTER_ID":37887,"ec":"2.1.1.n8","compounds":"S-adenosyl-L-methionine + small RNA 3'-end nucleotide = H(+) + S-adenosyl-L-homocysteine + small RNA 3'-end 2'-O-methylnucleotide"}
{"X":29949,"RHEA_ID":28034,"DIRECTION":"UN","MASTER_ID":28034,"ec":"1.17.4.1","compounds":"[thioredoxin]-disulfide + dADP + H2O = [thioredoxin]-dithiol + ADP"}
{"X":29950,"RHEA_ID":28035,"compounds":"[thioredoxin]-disulfide + dADP + H2O => [thioredoxin]-dithiol + ADP"}
{"X":29951,"RHEA_ID":37890,"compounds":"S-adenosyl-L-methionine + small RNA 3'-end nucleotide <=> H(+) + S-adenosyl-L-homocysteine + small RNA 3'-end 2'-O-methylnucleotide"}
{"X":29952,"RHEA_ID":37891,"DIRECTION":"UN","MASTER_ID":37891,"ec":"3.1.1.95","compounds":"aclacinomycin T + H2O = 15-demethylaclacinomycin T + methanol"}
{"X":29953,"RHEA_ID":28038,"DIRECTION":"UN","MASTER_ID":28038,"ec":"1.17.4.1","compounds":"[thioredoxin]-disulfide + dCDP + H2O = [thioredoxin]-dithiol + CDP"}
{"X":29954,"RHEA_ID":28039,"compounds":"[thioredoxin]-disulfide + dCDP + H2O => [thioredoxin]-dithiol + CDP"}
{"X":29955,"RHEA_ID":28040,"DIRECTION":"RL","MASTER_ID":28038,"ecocyc":"CDPREDUCT-RXN","metacyc":"CDPREDUCT-RXN","compounds":"[thioredoxin]-dithiol + CDP => [thioredoxin]-disulfide + dCDP + H2O"}
{"X":29956,"RHEA_ID":37895,"DIRECTION":"UN","MASTER_ID":37895,"ec":"3.2.1.186","compounds":"H2O + protodioscin = 26-deglucoprotodioscin + D-glucose"}
{"X":29957,"RHEA_ID":28042,"compounds":"CoA + NAD(+) + pyruvate = acetyl-CoA + CO2 + NADH"}
{"X":29958,"RHEA_ID":28043,"DIRECTION":"LR","MASTER_ID":28042,"ecocyc":"PYRUVDEH-RXN","reactome":"R-HSA-71397.2","compounds":"CoA + NAD(+) + pyruvate => acetyl-CoA + CO2 + NADH"}
{"X":29959,"RHEA_ID":37899,"DIRECTION":"UN","MASTER_ID":37899,"ec":"1.14.11.42","compounds":"2-oxoglutarate + 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + O2 = 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + CO2 + succinate"}
{"X":29960,"RHEA_ID":28046,"DIRECTION":"UN","MASTER_ID":28046,"ec":"2.3.1.222","compounds":"phosphate + propanoyl-CoA = CoA + propanoyl phosphate"}
{"X":29961,"RHEA_ID":28047,"DIRECTION":"LR","MASTER_ID":28046,"ecocyc":"PTAALT-RXN","metacyc":"PTAALT-RXN","compounds":"phosphate + propanoyl-CoA => CoA + propanoyl phosphate"}
{"X":29962,"RHEA_ID":47805,"compounds":"epothilone C + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => epothilone A + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":29963,"RHEA_ID":37903,"DIRECTION":"UN","MASTER_ID":37903,"ec":"2.1.1.293","compounds":"6-hydroxytryprostatin B + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + tryprostatin A"}
{"X":29964,"RHEA_ID":28050,"compounds":"H2O + NADP(+) = NAD(+) + phosphate"}
{"X":29965,"RHEA_ID":28051,"DIRECTION":"LR","MASTER_ID":28050,"ecocyc":"RXN-5822","metacyc":"RXN-5822","compounds":"H2O + NADP(+) => NAD(+) + phosphate"}
{"X":29966,"RHEA_ID":47809,"compounds":"epothilone D + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => epothilone B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":29967,"RHEA_ID":37907,"DIRECTION":"UN","MASTER_ID":37907,"ec":"1.13.11.77","compounds":"(9Z)-octadecenoate + O2 = (8E,10S)-10-hydroperoxy-octadeca-8-enoate"}
{"X":29968,"RHEA_ID":28054,"compounds":"2-oxobutanoate + CoA = formate + propanoyl-CoA"}
{"X":29969,"RHEA_ID":28055,"DIRECTION":"LR","MASTER_ID":28054,"ecocyc":"KETOBUTFORMLY-RXN","metacyc":"KETOBUTFORMLY-RXN","compounds":"2-oxobutanoate + CoA => formate + propanoyl-CoA"}
{"X":29970,"RHEA_ID":47813,"DIRECTION":"LR","MASTER_ID":47812,"metacyc":"RXN-4308","compounds":"H(+) + N(6)-(dimethylallyl)adenosine 5'-phosphate + NADPH + O2 => 9-ribosyl-trans-zeatin 5'-phosphate + H2O + NADP(+)"}
{"X":29971,"RHEA_ID":37911,"compounds":"(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoA"}
{"X":29972,"RHEA_ID":28058,"compounds":"L-lyxose = L-xylulose"}
{"X":29973,"RHEA_ID":28059,"compounds":"L-lyxose => L-xylulose"}
{"X":29974,"RHEA_ID":28060,"compounds":"L-xylulose => L-lyxose"}
{"X":29975,"RHEA_ID":37915,"compounds":"(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-glycerol + CoA"}
{"X":29976,"RHEA_ID":28062,"DIRECTION":"UN","MASTER_ID":28062,"ec":"2.4.99.13","compounds":"alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate = alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)"}
{"X":29977,"RHEA_ID":28063,"DIRECTION":"LR","MASTER_ID":28062,"ecocyc":"KDOTRANS2-RXN","metacyc":"KDOTRANS2-RXN","compounds":"alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)"}
{"X":29978,"RHEA_ID":28064,"compounds":"alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+) => alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate"}
{"X":29979,"RHEA_ID":37919,"DIRECTION":"UN","MASTER_ID":37919,"ec":"1.13.11.77","compounds":"(9Z,12Z)-octadecadienoate + O2 = (8E,10S,12Z)-10-hydroperoxyoctadeca-8,12-dienoate"}
{"X":29980,"RHEA_ID":28066,"DIRECTION":"UN","MASTER_ID":28066,"ec":"2.4.99.12","compounds":"CMP-3-deoxy-beta-D-manno-octulosonate + lipid IVA (E. coli) = alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)"}
{"X":29981,"RHEA_ID":47825,"compounds":"H(+) + malonyl-[ACP] + octadecanoyl-[ACP] => 3-oxoeicosanoyl-[ACP] + CO2 + holo-[ACP]"}
{"X":29982,"RHEA_ID":28068,"compounds":"alpha-Kdo-(2->6)-lipid IVA + CMP + H(+) => CMP-3-deoxy-beta-D-manno-octulosonate + lipid IVA (E. coli)"}
{"X":29983,"RHEA_ID":37924,"DIRECTION":"LR","MASTER_ID":37923,"metacyc":"RXN-14926","compounds":"(9Z,12Z,15Z)-octadecatrienoate + O2 => (8E,10S,12Z,15Z)-10-hydroperoxyoctadeca-8,12,15-trienoate"}
{"X":29984,"RHEA_ID":28070,"DIRECTION":"UN","MASTER_ID":28070,"ec":"2.5.1.141","compounds":"(2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate + Fe(II)-heme o"}
{"X":29985,"RHEA_ID":47829,"compounds":"ganglioside GT1b + H2O => ganglioside GD1b + N-acetylneuraminate"}
{"X":29986,"RHEA_ID":28072,"compounds":"diphosphate + Fe(II)-heme o => (2E,6E)-farnesyl diphosphate + H2O + heme b"}
{"X":29987,"RHEA_ID":37928,"compounds":"(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O"}
{"X":29988,"RHEA_ID":28074,"DIRECTION":"UN","MASTER_ID":28074,"ec":"1.1.1.308","compounds":"(2R)-3-sulfopropanediol + H2O + 2 NAD(+) = (R)-3-sulfolactate + 3 H(+) + 2 NADH"}
{"X":29989,"RHEA_ID":37930,"DIRECTION":"BI","MASTER_ID":37927,"metacyc":"RXN-14945","compounds":"(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate <=> 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O"}
{"X":29990,"RHEA_ID":28076,"compounds":"(R)-3-sulfolactate + 3 H(+) + 2 NADH => (2R)-3-sulfopropanediol + H2O + 2 NAD(+)"}
{"X":29991,"RHEA_ID":37932,"compounds":"(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => (10R)-hydroxy-(8S,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate"}
{"X":29992,"RHEA_ID":28078,"DIRECTION":"UN","MASTER_ID":28078,"ec":"1.1.1.309","compounds":"2-hydroxyethylphosphonate + NAD(+) = H(+) + NADH + phosphonoacetaldehyde"}
{"X":29993,"RHEA_ID":37934,"DIRECTION":"BI","MASTER_ID":37931,"metacyc":"RXN-14953","compounds":"(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate <=> (10R)-hydroxy-(8S,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate"}
{"X":29994,"RHEA_ID":28080,"compounds":"H(+) + NADH + phosphonoacetaldehyde => 2-hydroxyethylphosphonate + NAD(+)"}
{"X":29995,"RHEA_ID":37936,"compounds":"(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O"}
{"X":29996,"RHEA_ID":28082,"DIRECTION":"UN","MASTER_ID":28082,"ec":"1.3.1.85","compounds":"(2S)-ethylmalonyl-CoA + NADP(+) = (2E)-butenoyl-CoA + CO2 + NADPH"}
{"X":29997,"RHEA_ID":37938,"DIRECTION":"BI","MASTER_ID":37935,"metacyc":"RXN-14944","compounds":"(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate <=> 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O"}
{"X":29998,"RHEA_ID":28084,"compounds":"(2E)-butenoyl-CoA + CO2 + NADPH => (2S)-ethylmalonyl-CoA + NADP(+)"}
{"X":29999,"RHEA_ID":28085,"compounds":"(2S)-ethylmalonyl-CoA + NADP(+) <=> (2E)-butenoyl-CoA + CO2 + NADPH"}
{"X":30000,"RHEA_ID":28086,"DIRECTION":"UN","MASTER_ID":28086,"ec":"1.11.1.19","compounds":"2 H2O2 + Reactive Blue 5 = 2,2'-disulfonyl azobenzene + 3-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]benzenesulfonate + 2 H(+) + 2 H2O + phthalate"}
{"X":30001,"RHEA_ID":37942,"DIRECTION":"BI","MASTER_ID":37939,"metacyc":"RXN-14952","compounds":"(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate <=> (8R)-hydroxy-(11R,12R)-epoxy-(5Z,9E,14Z)-eicosatrienoate"}
{"X":30002,"RHEA_ID":28088,"compounds":"2,2'-disulfonyl azobenzene + 3-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]benzenesulfonate + 2 H(+) + 2 H2O + phthalate => 2 H2O2 + Reactive Blue 5"}
{"X":30003,"RHEA_ID":37944,"compounds":"(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O"}
{"X":30004,"RHEA_ID":28090,"DIRECTION":"UN","MASTER_ID":28090,"ec":"2.7.8.33","compounds":"di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UMP"}
{"X":30005,"RHEA_ID":37946,"DIRECTION":"BI","MASTER_ID":37943,"metacyc":"RXN-14943","compounds":"(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate <=> 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O"}
{"X":30006,"RHEA_ID":28092,"compounds":"N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UMP => di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":30007,"RHEA_ID":37948,"compounds":"(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O"}
{"X":30008,"RHEA_ID":28094,"DIRECTION":"UN","MASTER_ID":28094,"ec":"3.6.1.27","compounds":"di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate"}
{"X":30009,"RHEA_ID":37950,"DIRECTION":"BI","MASTER_ID":37947,"metacyc":"RXN-14942","compounds":"(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate <=> 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O"}
{"X":30010,"RHEA_ID":28096,"compounds":"di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate => di-trans,octa-cis-undecaprenyl diphosphate + H2O"}
{"X":30011,"RHEA_ID":37952,"compounds":"(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => (10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate"}
{"X":30012,"RHEA_ID":28098,"compounds":"ATP + GDP = AMP + guanosine 3',5'-bis(diphosphate)"}
{"X":30013,"RHEA_ID":37954,"DIRECTION":"BI","MASTER_ID":37951,"metacyc":"RXN-14951","compounds":"(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate <=> (10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate"}
{"X":30014,"RHEA_ID":28100,"compounds":"AMP + guanosine 3',5'-bis(diphosphate) => ATP + GDP"}
{"X":30015,"RHEA_ID":28101,"compounds":"ATP + GDP <=> AMP + guanosine 3',5'-bis(diphosphate)"}
{"X":30016,"RHEA_ID":28102,"compounds":"GDP-alpha-D-mannose + H2O = D-mannose + GDP + H(+)"}
{"X":30017,"RHEA_ID":28103,"DIRECTION":"LR","MASTER_ID":28102,"ecocyc":"GDPMANMANHYDRO-RXN","metacyc":"GDPMANMANHYDRO-RXN","compounds":"GDP-alpha-D-mannose + H2O => D-mannose + GDP + H(+)"}
{"X":30018,"RHEA_ID":28104,"compounds":"D-mannose + GDP + H(+) => GDP-alpha-D-mannose + H2O"}
{"X":30019,"RHEA_ID":28105,"compounds":"GDP-alpha-D-mannose + H2O <=> D-mannose + GDP + H(+)"}
{"X":30020,"RHEA_ID":28106,"DIRECTION":"UN","MASTER_ID":28106,"ec":"1.1.1.251","compounds":"galactitol 1-phosphate + NAD(+) = H(+) + keto-D-tagatose 6-phosphate + NADH"}
{"X":30021,"RHEA_ID":28107,"compounds":"galactitol 1-phosphate + NAD(+) => H(+) + keto-D-tagatose 6-phosphate + NADH"}
{"X":30022,"RHEA_ID":28108,"compounds":"H(+) + keto-D-tagatose 6-phosphate + NADH => galactitol 1-phosphate + NAD(+)"}
{"X":30023,"RHEA_ID":37964,"compounds":"galactitol + NAD(+) => D-galactose + H(+) + NADH"}
{"X":30024,"RHEA_ID":28110,"DIRECTION":"UN","MASTER_ID":28110,"ec":"2.5.1.94","compounds":"chloride + S-adenosyl-L-methionine = 5'-chloro-5'-deoxyadenosine + L-methionine"}
{"X":30025,"RHEA_ID":47869,"compounds":"di-(9Z)-octadecenoylglycerol + H2O => (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)"}
{"X":30026,"RHEA_ID":28112,"compounds":"5'-chloro-5'-deoxyadenosine + L-methionine => chloride + S-adenosyl-L-methionine"}
{"X":30027,"RHEA_ID":37968,"compounds":"galactitol + NADP(+) => D-galactose + H(+) + NADPH"}
{"X":30028,"RHEA_ID":28114,"compounds":"di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-glucose = alpha-D-galactosyl-diphosphoundecaprenol + UMP"}
{"X":30029,"RHEA_ID":28115,"compounds":"di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-glucose => alpha-D-galactosyl-diphosphoundecaprenol + UMP"}
{"X":30030,"RHEA_ID":28116,"compounds":"alpha-D-galactosyl-diphosphoundecaprenol + UMP => di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-glucose"}
{"X":30031,"RHEA_ID":37972,"compounds":"H(+) + NADPH + O2 + octadecanoyl-CoA => (9Z)-octadecenoyl-CoA + 2 H2O + NADP(+)"}
{"X":30032,"RHEA_ID":28118,"DIRECTION":"UN","MASTER_ID":28118,"ec":"2.4.1.54","compounds":"di-trans,octa-cis-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl di-trans,octa-cis-undecaprenyl phosphate + GDP"}
{"X":30033,"RHEA_ID":37974,"compounds":"H(+) + NADPH + O2 + octadecanoyl-CoA <=> (9Z)-octadecenoyl-CoA + 2 H2O + NADP(+)"}
{"X":30034,"RHEA_ID":28120,"compounds":"D-mannosyl di-trans,octa-cis-undecaprenyl phosphate + GDP => di-trans,octa-cis-undecaprenyl phosphate + GDP-alpha-D-mannose"}
{"X":30035,"RHEA_ID":37976,"DIRECTION":"LR","MASTER_ID":37975,"metacyc":"RXN-2541","compounds":"H(+) + homogentisate + phytyl diphosphate => 2-methyl-6-phytyl-1,4-benzene-1,4-diol + CO2 + diphosphate"}
{"X":30036,"RHEA_ID":28122,"DIRECTION":"UN","MASTER_ID":28122,"ec":"2.7.1.66","compounds":"ATP + di-trans,octa-cis-undecaprenol = ADP + di-trans,octa-cis-undecaprenyl phosphate + H(+)"}
{"X":30037,"RHEA_ID":47881,"compounds":"dioctanoylglycerol + H2O => H(+) + octanoate + octanoylglycerol"}
{"X":30038,"RHEA_ID":28124,"compounds":"ADP + di-trans,octa-cis-undecaprenyl phosphate + H(+) => ATP + di-trans,octa-cis-undecaprenol"}
{"X":30039,"RHEA_ID":37980,"DIRECTION":"LR","MASTER_ID":37979,"metacyc":"RXN-2542","compounds":"2-methyl-6-phytyl-1,4-benzene-1,4-diol + S-adenosyl-L-methionine => 2,3-dimethyl-6-phytylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine"}
{"X":30040,"RHEA_ID":28126,"DIRECTION":"UN","MASTER_ID":28126,"ec":"2.7.8.31","compounds":"di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-glucose = alpha-D-glucosyl di-trans,octa-cis-undecaprenyl diphosphate + UMP"}
{"X":30041,"RHEA_ID":28127,"compounds":"di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-glucose => alpha-D-glucosyl di-trans,octa-cis-undecaprenyl diphosphate + UMP"}
{"X":30042,"RHEA_ID":28128,"compounds":"alpha-D-glucosyl di-trans,octa-cis-undecaprenyl diphosphate + UMP => di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-glucose"}
{"X":30043,"RHEA_ID":28129,"compounds":"di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-glucose <=> alpha-D-glucosyl di-trans,octa-cis-undecaprenyl diphosphate + UMP"}
{"X":30044,"RHEA_ID":28130,"DIRECTION":"UN","MASTER_ID":28130,"ec":"3.2.1.167","compounds":"baicalin + H2O = baicalein + D-glucuronate + H(+)"}
{"X":30045,"RHEA_ID":47889,"compounds":"GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine => GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine"}
{"X":30046,"RHEA_ID":28132,"compounds":"baicalein + D-glucuronate + H(+) => baicalin + H2O"}
{"X":30047,"RHEA_ID":37988,"compounds":"delta-tocopherol => 2-methyl-6-phytyl-1,4-benzene-1,4-diol"}
{"X":30048,"RHEA_ID":28134,"DIRECTION":"UN","MASTER_ID":28134,"ec":"3.2.1.168","compounds":"H2O + hesperidin = hesperetin + rutinose"}
{"X":30049,"RHEA_ID":47893,"compounds":"GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine => GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->6)-N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine"}
{"X":30050,"RHEA_ID":28136,"compounds":"hesperetin + rutinose => H2O + hesperidin"}
{"X":30051,"RHEA_ID":37992,"compounds":"delta-tocopherol + S-adenosyl-L-methionine => beta-tocopherol + H(+) + S-adenosyl-L-homocysteine"}
{"X":30052,"RHEA_ID":28138,"DIRECTION":"UN","MASTER_ID":28138,"ec":"3.5.2.19","compounds":"H2O + streptothricin F = streptothricin F acid"}
{"X":30053,"RHEA_ID":28139,"compounds":"H2O + streptothricin F => streptothricin F acid"}
{"X":30054,"RHEA_ID":28140,"compounds":"streptothricin F acid => H2O + streptothricin F"}
{"X":30055,"RHEA_ID":37996,"DIRECTION":"LR","MASTER_ID":37995,"metacyc":"RXN-2761","compounds":"all-trans-nonaprenyl diphosphate + H(+) + homogentisate => 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2 + diphosphate"}
{"X":30056,"RHEA_ID":28142,"DIRECTION":"UN","MASTER_ID":28142,"ec":"3.5.2.19","compounds":"H2O + streptothricin D = streptothricin D acid"}
{"X":30057,"RHEA_ID":47901,"compounds":"ganglioside GM3 (d18:1(4E)) + H2O => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetylneuraminate"}
{"X":30058,"RHEA_ID":28144,"compounds":"streptothricin D acid => H2O + streptothricin D"}
{"X":30059,"RHEA_ID":28145,"DIRECTION":"BI","MASTER_ID":28142,"metacyc":"RXN-11753","compounds":"H2O + streptothricin D <=> streptothricin D acid"}
{"X":30060,"RHEA_ID":28146,"DIRECTION":"UN","MASTER_ID":28146,"ec":"1.14.13.116","compounds":"geranylhydroquinone + O2 + reduced [NADPH--hemoprotein reductase] = 3''-hydroxy-geranylhydroquinone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":30061,"RHEA_ID":47905,"compounds":"ATP + N-(acetyl)-sphing-4-enine => ADP + H(+) + N-(acetyl)-sphing-4-enine-1-phosphate"}
{"X":30062,"RHEA_ID":28148,"compounds":"3''-hydroxy-geranylhydroquinone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => geranylhydroquinone + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":30063,"RHEA_ID":28149,"compounds":"geranylhydroquinone + O2 + reduced [NADPH--hemoprotein reductase] <=> 3''-hydroxy-geranylhydroquinone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":30064,"RHEA_ID":28150,"DIRECTION":"UN","MASTER_ID":28150,"ec":"2.3.1.57","compounds":"acetyl-CoA + spermidine = CoA + H(+) + N(1)-acetylspermidine"}
{"X":30065,"RHEA_ID":28151,"DIRECTION":"LR","MASTER_ID":28150,"metacyc":"RXN-9943","reactome":"R-HSA-351208.1","compounds":"acetyl-CoA + spermidine => CoA + H(+) + N(1)-acetylspermidine"}
{"X":30066,"RHEA_ID":28152,"compounds":"CoA + H(+) + N(1)-acetylspermidine => acetyl-CoA + spermidine"}
{"X":30067,"RHEA_ID":28153,"DIRECTION":"BI","MASTER_ID":28150,"ecocyc":"SPERMACTRAN-RXN","metacyc":"SPERMACTRAN-RXN","compounds":"acetyl-CoA + spermidine <=> CoA + H(+) + N(1)-acetylspermidine"}
{"X":30068,"RHEA_ID":28154,"DIRECTION":"UN","MASTER_ID":28154,"ec":"2.4.99.14","compounds":"alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate = alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)"}
{"X":30069,"RHEA_ID":47913,"DIRECTION":"LR","MASTER_ID":47912,"metacyc":"RXN-17097","compounds":"6-deoxy-6-sulfo-D-gluconate => 2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate + H2O"}
{"X":30070,"RHEA_ID":28156,"compounds":"alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+) => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate"}
{"X":30071,"RHEA_ID":38012,"DIRECTION":"LR","MASTER_ID":38011,"metacyc":"RXN-7738","compounds":"chlorophyll a + H2O => chlorophyllide a + H(+) + phytol"}
{"X":30072,"RHEA_ID":47917,"compounds":"ATP + N-(hexanoyl)-4-hydroxysphinganine => ADP + H(+) + N-(hexanoyl)-4-hydroxysphinganine-1-phosphate"}
{"X":30073,"RHEA_ID":28159,"DIRECTION":"LR","MASTER_ID":28158,"metacyc":"RXN-11327","compounds":"alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate => alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)"}
{"X":30074,"RHEA_ID":28160,"compounds":"alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+) => alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate"}
{"X":30075,"RHEA_ID":47921,"compounds":"ganglioside GM2 (d18:1(4E)/18:0) + H2O => ganglioside GA2 (d18:1(4E)/18:0) + N-acetylneuraminate"}
{"X":30076,"RHEA_ID":28162,"DIRECTION":"UN","MASTER_ID":28162,"ec":"2.7.1.213","compounds":"cytidine + GTP = CMP + GDP + H(+)"}
{"X":30077,"RHEA_ID":28163,"compounds":"cytidine + GTP => CMP + GDP + H(+)"}
{"X":30078,"RHEA_ID":28164,"compounds":"CMP + GDP + H(+) => cytidine + GTP"}
{"X":30079,"RHEA_ID":47925,"DIRECTION":"LR","MASTER_ID":47924,"metacyc":"RXN-17098","compounds":"2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate => (S)-3-sulfolactaldehyde + pyruvate"}
{"X":30080,"RHEA_ID":28166,"DIRECTION":"UN","MASTER_ID":28166,"ec":"3.5.99.8","compounds":"5-nitroanthranilate + H(+) + H2O = 5-nitrosalicylate + NH4(+)"}
{"X":30081,"RHEA_ID":28167,"DIRECTION":"LR","MASTER_ID":28166,"metacyc":"RXN-11730","compounds":"5-nitroanthranilate + H(+) + H2O => 5-nitrosalicylate + NH4(+)"}
{"X":30082,"RHEA_ID":28168,"compounds":"5-nitrosalicylate + NH4(+) => 5-nitroanthranilate + H(+) + H2O"}
{"X":30083,"RHEA_ID":47929,"DIRECTION":"LR","MASTER_ID":47928,"metacyc":"RXN-17101","compounds":"(S)-3-sulfolactaldehyde + H2O + NADP(+) => (S)-3-sulfolactate + 2 H(+) + NADPH"}
{"X":30084,"RHEA_ID":28170,"DIRECTION":"UN","MASTER_ID":28170,"ec":"4.1.2.46","compounds":"(2R)-2-hydroxy-2-methylbutanenitrile = butan-2-one + hydrogen cyanide"}
{"X":30085,"RHEA_ID":28171,"DIRECTION":"LR","MASTER_ID":28170,"metacyc":"RXN-11733","compounds":"(2R)-2-hydroxy-2-methylbutanenitrile => butan-2-one + hydrogen cyanide"}
{"X":30086,"RHEA_ID":28172,"compounds":"butan-2-one + hydrogen cyanide => (2R)-2-hydroxy-2-methylbutanenitrile"}
{"X":30087,"RHEA_ID":47933,"DIRECTION":"LR","MASTER_ID":47932,"metacyc":"RXN-17101","compounds":"(S)-3-sulfolactaldehyde + H2O + NAD(+) => (R)-3-sulfolactate + 2 H(+) + NADH"}
{"X":30088,"RHEA_ID":28174,"DIRECTION":"UN","MASTER_ID":28174,"ec":"4.2.1.121","compounds":"(9S)-hydroperoxy-(10E,12Z)-octadecadienoate = colneleate + H2O"}
{"X":30089,"RHEA_ID":28175,"DIRECTION":"LR","MASTER_ID":28174,"metacyc":"RXN-8496","compounds":"(9S)-hydroperoxy-(10E,12Z)-octadecadienoate => colneleate + H2O"}
{"X":30090,"RHEA_ID":28176,"compounds":"colneleate + H2O => (9S)-hydroperoxy-(10E,12Z)-octadecadienoate"}
{"X":30091,"RHEA_ID":47937,"DIRECTION":"LR","MASTER_ID":47936,"metacyc":"HYDROXYBENZALDEHYDE-OXIDATION-NADP-RXN","compounds":"4-hydroxybenzaldehyde + H2O + NADP(+) => 4-hydroxybenzoate + 2 H(+) + NADPH"}
{"X":30092,"RHEA_ID":28178,"DIRECTION":"UN","MASTER_ID":28178,"ec":"4.2.1.121","compounds":"(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate = colnelenate + H2O"}
{"X":30093,"RHEA_ID":28179,"DIRECTION":"LR","MASTER_ID":28178,"metacyc":"RXN-8498","compounds":"(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate => colnelenate + H2O"}
{"X":30094,"RHEA_ID":28180,"compounds":"colnelenate + H2O => (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate"}
{"X":30095,"RHEA_ID":38038,"compounds":"(2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate <=> (4Z)-2-oxohept-4-enedioate"}
{"X":30096,"RHEA_ID":28182,"DIRECTION":"UN","MASTER_ID":28182,"ec":"5.3.3.17","compounds":"(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate = (1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate"}
{"X":30097,"RHEA_ID":28183,"DIRECTION":"LR","MASTER_ID":28182,"metacyc":"RXN-9031","compounds":"(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate => (1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate"}
{"X":30098,"RHEA_ID":28184,"compounds":"(1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate => (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate"}
{"X":30099,"RHEA_ID":47945,"DIRECTION":"LR","MASTER_ID":47944,"metacyc":"RXN-17104","compounds":"(2E)-geranyl diphosphate + H2O => (2E)-geranyl phosphate + H(+) + phosphate"}
{"X":30100,"RHEA_ID":28186,"compounds":"aminoacetone + H2O + O2 = H2O2 + methylglyoxal + NH4(+)"}
{"X":30101,"RHEA_ID":28187,"DIRECTION":"LR","MASTER_ID":28186,"ecocyc":"AMACETOXID-RXN","metacyc":"AMACETOXID-RXN","compounds":"aminoacetone + H2O + O2 => H2O2 + methylglyoxal + NH4(+)"}
{"X":30102,"RHEA_ID":28188,"compounds":"H2O2 + methylglyoxal + NH4(+) => aminoacetone + H2O + O2"}
{"X":30103,"RHEA_ID":28190,"compounds":"2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+)"}
{"X":30104,"RHEA_ID":28191,"DIRECTION":"LR","MASTER_ID":28190,"reactome":"R-HSA-74241.4","compounds":"2'-deoxyadenosine + H(+) + H2O => 2'-deoxyinosine + NH4(+)"}
{"X":30105,"RHEA_ID":28192,"compounds":"2'-deoxyinosine + NH4(+) => 2'-deoxyadenosine + H(+) + H2O"}
{"X":30106,"RHEA_ID":38050,"compounds":"2 [Fe(II)-cytochrome b5] + a (9Z)-octadecenoyl-containing glycerolipid + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a (9Z,12E)-octadecadienoyl-containing glycerolipid + 2 H2O"}
{"X":30107,"RHEA_ID":28194,"DIRECTION":"UN","MASTER_ID":28194,"ec":"1.1.1.310","compounds":"(S)-3-sulfolactate + NAD(+) = 3-sulfopyruvate + H(+) + NADH"}
{"X":30108,"RHEA_ID":28195,"compounds":"(S)-3-sulfolactate + NAD(+) => 3-sulfopyruvate + H(+) + NADH"}
{"X":30109,"RHEA_ID":28196,"compounds":"3-sulfopyruvate + H(+) + NADH => (S)-3-sulfolactate + NAD(+)"}
{"X":30110,"RHEA_ID":47957,"DIRECTION":"LR","MASTER_ID":47956,"metacyc":"RXN-10447","compounds":"3-maleylpyruvate + H2O => H(+) + maleate + pyruvate"}
{"X":30111,"RHEA_ID":28198,"DIRECTION":"UN","MASTER_ID":28198,"ec":"1.1.1.311","compounds":"(S)-1-phenylethanol + NAD(+) = acetophenone + H(+) + NADH"}
{"X":30112,"RHEA_ID":28199,"compounds":"(S)-1-phenylethanol + NAD(+) => acetophenone + H(+) + NADH"}
{"X":30113,"RHEA_ID":28200,"compounds":"acetophenone + H(+) + NADH => (S)-1-phenylethanol + NAD(+)"}
{"X":30114,"RHEA_ID":57994,"compounds":"(20S)-ginsenoside F2 + H(+) + UDP => (20S)-ginsenoside C-K + UDP-alpha-D-glucose"}
{"X":30115,"RHEA_ID":28202,"DIRECTION":"UN","MASTER_ID":28202,"ec":"1.3.7.7","compounds":"2 ADP + chlorophyllide a + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate = 2 ATP + 2 H2O + protochlorophyllide a + reduced 2[4Fe-4S]-[ferredoxin]"}
{"X":30116,"RHEA_ID":28203,"compounds":"2 ADP + chlorophyllide a + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate => 2 ATP + 2 H2O + protochlorophyllide a + reduced 2[4Fe-4S]-[ferredoxin]"}
{"X":30117,"RHEA_ID":28204,"DIRECTION":"RL","MASTER_ID":28202,"metacyc":"RXN-11902","compounds":"2 ATP + 2 H2O + protochlorophyllide a + reduced 2[4Fe-4S]-[ferredoxin] => 2 ADP + chlorophyllide a + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate"}
{"X":30118,"RHEA_ID":47964,"DIRECTION":"UN","MASTER_ID":47964,"ec":"3.9.1.3","compounds":"H2O + N(pros)-phospho-L-histidyl-[protein] = L-histidyl-[protein] + phosphate"}
{"X":30119,"RHEA_ID":28206,"compounds":"2'-deoxyuridine + ATP = ADP + dUMP + H(+)"}
{"X":30120,"RHEA_ID":28207,"DIRECTION":"LR","MASTER_ID":28206,"ecocyc":"DURIDKI-RXN","metacyc":"DURIDKI-RXN","compounds":"2'-deoxyuridine + ATP => ADP + dUMP + H(+)"}
{"X":30121,"RHEA_ID":28208,"compounds":"ADP + dUMP + H(+) => 2'-deoxyuridine + ATP"}
{"X":30122,"RHEA_ID":28210,"DIRECTION":"UN","MASTER_ID":28210,"ec":"1.5.3.18","compounds":"H2O + L-saccharopine + O2 = (S)-2-amino-6-oxohexanoate + H2O2 + L-glutamate"}
{"X":30123,"RHEA_ID":28211,"DIRECTION":"LR","MASTER_ID":28210,"metacyc":"RXN-10744","compounds":"H2O + L-saccharopine + O2 => (S)-2-amino-6-oxohexanoate + H2O2 + L-glutamate"}
{"X":30124,"RHEA_ID":28212,"compounds":"(S)-2-amino-6-oxohexanoate + H2O2 + L-glutamate => H2O + L-saccharopine + O2"}
{"X":30125,"RHEA_ID":47971,"compounds":"ganglioside GM2 + H2O <=> ganglioside GM3 + N-acetyl-beta-D-galactosamine"}
{"X":30126,"RHEA_ID":28214,"DIRECTION":"UN","MASTER_ID":28214,"ec":"1.11.1.20","compounds":"[thioredoxin]-dithiol + prostaglandin H2 = [thioredoxin]-disulfide + prostaglandin F2alpha"}
{"X":30127,"RHEA_ID":28215,"compounds":"[thioredoxin]-dithiol + prostaglandin H2 => [thioredoxin]-disulfide + prostaglandin F2alpha"}
{"X":30128,"RHEA_ID":28216,"compounds":"[thioredoxin]-disulfide + prostaglandin F2alpha => [thioredoxin]-dithiol + prostaglandin H2"}
{"X":30129,"RHEA_ID":58009,"DIRECTION":"LR","MASTER_ID":58008,"metacyc":"RXN-19700","compounds":"(20S)-ginsenoside F1 + UDP-alpha-D-glucose => (20S)-ginsenoside Rg1 + H(+) + UDP"}
{"X":30130,"RHEA_ID":28218,"DIRECTION":"UN","MASTER_ID":28218,"ec":"1.11.2.2","compounds":"chloride + H(+) + H2O2 = H2O + hypochlorous acid"}
{"X":30131,"RHEA_ID":28219,"DIRECTION":"LR","MASTER_ID":28218,"reactome":"R-HSA-6789126.1","compounds":"chloride + H(+) + H2O2 => H2O + hypochlorous acid"}
{"X":30132,"RHEA_ID":28219,"DIRECTION":"LR","MASTER_ID":28218,"reactome":"R-HSA-6789031.1","compounds":"chloride + H(+) + H2O2 => H2O + hypochlorous acid"}
{"X":30133,"RHEA_ID":38078,"compounds":"2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA"}
{"X":30134,"RHEA_ID":28222,"compounds":"3-dehydro-L-gulonate + ATP = 3-dehydro-L-gulonate 6-phosphate + ADP + H(+)"}
{"X":30135,"RHEA_ID":38082,"compounds":"2-(9Z-octadecenoyl)-glycerol + eicosanoyl-CoA <=> 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA"}
{"X":30136,"RHEA_ID":28224,"compounds":"3-dehydro-L-gulonate 6-phosphate + ADP + H(+) => 3-dehydro-L-gulonate + ATP"}
{"X":30137,"RHEA_ID":28225,"compounds":"3-dehydro-L-gulonate + ATP <=> 3-dehydro-L-gulonate 6-phosphate + ADP + H(+)"}
{"X":30138,"RHEA_ID":28226,"DIRECTION":"UN","MASTER_ID":28226,"ec":"1.14.14.149","compounds":"(+)-5-epi-aristolochene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = capsidiol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":30139,"RHEA_ID":28227,"DIRECTION":"LR","MASTER_ID":28226,"metacyc":"RXN-11908","compounds":"(+)-5-epi-aristolochene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => capsidiol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":30140,"RHEA_ID":28228,"compounds":"capsidiol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => (+)-5-epi-aristolochene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}
{"X":30141,"RHEA_ID":38088,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol => 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA"}
{"X":30142,"RHEA_ID":28230,"DIRECTION":"UN","MASTER_ID":28230,"ec":"1.14.14.150","compounds":"germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = (+)-costunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":30143,"RHEA_ID":38090,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol <=> 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA"}
{"X":30144,"RHEA_ID":28232,"compounds":"(+)-costunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":30145,"RHEA_ID":38092,"compounds":"delta-tocotrienol + S-adenosyl-L-methionine => beta-tocotrienol + H(+) + S-adenosyl-L-homocysteine"}
{"X":30146,"RHEA_ID":28234,"compounds":"L-glutamate 5-semialdehyde = (S)-1-pyrroline-5-carboxylate + H(+) + H2O"}
{"X":30147,"RHEA_ID":38094,"compounds":"delta-tocotrienol + S-adenosyl-L-methionine <=> beta-tocotrienol + H(+) + S-adenosyl-L-homocysteine"}
{"X":30148,"RHEA_ID":28236,"DIRECTION":"RL","MASTER_ID":28234,"reactome":"R-HSA-70667.3","compounds":"(S)-1-pyrroline-5-carboxylate + H(+) + H2O => L-glutamate 5-semialdehyde"}
{"X":30149,"RHEA_ID":38096,"compounds":"gamma-tocotrienol + S-adenosyl-L-methionine => alpha-tocotrienol + H(+) + S-adenosyl-L-homocysteine"}
{"X":30150,"RHEA_ID":28238,"DIRECTION":"UN","MASTER_ID":28238,"ec":"1.14.19.63","compounds":"calycosin + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + pseudobaptigenin"}
{"X":30151,"RHEA_ID":38098,"compounds":"gamma-tocotrienol + S-adenosyl-L-methionine <=> alpha-tocotrienol + H(+) + S-adenosyl-L-homocysteine"}
{"X":30152,"RHEA_ID":28240,"compounds":"H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + pseudobaptigenin => calycosin + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":30153,"RHEA_ID":38100,"DIRECTION":"LR","MASTER_ID":38099,"metacyc":"RXN-7763","compounds":"a ribonucleoside 5'-triphosphate + phytyl phosphate => a ribonucleoside 5'-diphosphate + phytyl diphosphate"}
{"X":30154,"RHEA_ID":28242,"DIRECTION":"UN","MASTER_ID":28242,"ec":"1.14.19.63","compounds":"O2 + pratensein + reduced [NADPH--hemoprotein reductase] = 5-hydroxypseudobaptigenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":30155,"RHEA_ID":28243,"DIRECTION":"LR","MASTER_ID":28242,"metacyc":"RXN-11547","compounds":"O2 + pratensein + reduced [NADPH--hemoprotein reductase] => 5-hydroxypseudobaptigenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":30156,"RHEA_ID":38103,"DIRECTION":"UN","MASTER_ID":38103,"ec":"4.2.1.146","compounds":"L-galactonate = 2-dehydro-3-deoxy-L-galactonate + H2O"}
{"X":30157,"RHEA_ID":38104,"DIRECTION":"LR","MASTER_ID":38103,"metacyc":"RXN-11380","compounds":"L-galactonate => 2-dehydro-3-deoxy-L-galactonate + H2O"}
{"X":30158,"RHEA_ID":28246,"DIRECTION":"UN","MASTER_ID":28246,"ec":"2.7.1.169","compounds":"(R)-pantoate + ATP = (R)-4-phosphopantoate + ADP + H(+)"}
{"X":30159,"RHEA_ID":28247,"DIRECTION":"LR","MASTER_ID":28246,"metacyc":"RXN-11782","compounds":"(R)-pantoate + ATP => (R)-4-phosphopantoate + ADP + H(+)"}
{"X":30160,"RHEA_ID":38107,"DIRECTION":"UN","MASTER_ID":38107,"ec":"4.1.2.54","compounds":"2-dehydro-3-deoxy-L-galactonate = L-glyceraldehyde + pyruvate"}
{"X":30161,"RHEA_ID":38108,"compounds":"2-dehydro-3-deoxy-L-galactonate => L-glyceraldehyde + pyruvate"}
{"X":30162,"RHEA_ID":28250,"DIRECTION":"UN","MASTER_ID":28250,"ec":"2.3.1.194","compounds":"acetyl-CoA + H(+) + malonyl-CoA = acetoacetyl-CoA + CO2 + CoA"}
{"X":30163,"RHEA_ID":28251,"compounds":"acetyl-CoA + H(+) + malonyl-CoA => acetoacetyl-CoA + CO2 + CoA"}
{"X":30164,"RHEA_ID":38111,"DIRECTION":"UN","MASTER_ID":38111,"ec":"1.1.1.372","compounds":"glycerol + NADP(+) = H(+) + L-glyceraldehyde + NADPH"}
{"X":30165,"RHEA_ID":38112,"compounds":"glycerol + NADP(+) => H(+) + L-glyceraldehyde + NADPH"}
{"X":30166,"RHEA_ID":28254,"DIRECTION":"UN","MASTER_ID":28254,"ec":"2.3.1.195","compounds":"(3Z)-hex-3-en-1-ol + acetyl-CoA = (3Z)-hex-3-en-1-yl acetate + CoA"}
{"X":30167,"RHEA_ID":28255,"DIRECTION":"LR","MASTER_ID":28254,"metacyc":"RXN-11852","compounds":"(3Z)-hex-3-en-1-ol + acetyl-CoA => (3Z)-hex-3-en-1-yl acetate + CoA"}
{"X":30168,"RHEA_ID":38115,"compounds":"(9Z)-octadecenoyl-CoA + 1-dodecanoylglycerol = 1-dodecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA"}
{"X":30169,"RHEA_ID":38116,"compounds":"(9Z)-octadecenoyl-CoA + 1-dodecanoylglycerol => 1-dodecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA"}
{"X":30170,"RHEA_ID":28258,"DIRECTION":"UN","MASTER_ID":28258,"ec":"2.4.1.254","compounds":"cyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucuronate = cyanidin 3-O-(2-O-beta-D-glucuronosyl)-beta-D-glucoside + H(+) + UDP"}
{"X":30171,"RHEA_ID":28259,"compounds":"cyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucuronate => cyanidin 3-O-(2-O-beta-D-glucuronosyl)-beta-D-glucoside + H(+) + UDP"}
{"X":30172,"RHEA_ID":38119,"compounds":"(9Z)-octadecenoyl-CoA + 1-tetradecanoylglycerol = 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA"}
{"X":30173,"RHEA_ID":38120,"compounds":"(9Z)-octadecenoyl-CoA + 1-tetradecanoylglycerol => 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA"}
{"X":30174,"RHEA_ID":28262,"DIRECTION":"UN","MASTER_ID":28262,"ec":"2.7.8.32","compounds":"3-alpha-D-mannopyranosyl-alpha-D-mannopyranose + UDP-alpha-D-xylose = 3-O-(6-O-alpha-D-xylosylphospho-alpha-D-mannopyranosyl)-alpha-D-mannopyranose + H(+) + UMP"}
{"X":30175,"RHEA_ID":28263,"compounds":"3-alpha-D-mannopyranosyl-alpha-D-mannopyranose + UDP-alpha-D-xylose => 3-O-(6-O-alpha-D-xylosylphospho-alpha-D-mannopyranosyl)-alpha-D-mannopyranose + H(+) + UMP"}
{"X":30176,"RHEA_ID":38123,"compounds":"(9Z)-octadecenoyl-CoA + 1-hexadecanoylglycerol = 1-hexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA"}
{"X":30177,"RHEA_ID":38124,"compounds":"(9Z)-octadecenoyl-CoA + 1-hexadecanoylglycerol => 1-hexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA"}
{"X":30178,"RHEA_ID":28266,"DIRECTION":"UN","MASTER_ID":28266,"ec":"4.2.3.55","compounds":"(2E,6E)-farnesyl diphosphate = (S)-beta-bisabolene + diphosphate"}
{"X":30179,"RHEA_ID":28267,"compounds":"(2E,6E)-farnesyl diphosphate => (S)-beta-bisabolene + diphosphate"}
{"X":30180,"RHEA_ID":28268,"compounds":"(S)-beta-bisabolene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":30181,"RHEA_ID":28269,"DIRECTION":"BI","MASTER_ID":28266,"metacyc":"RXN-8429","compounds":"(2E,6E)-farnesyl diphosphate <=> (S)-beta-bisabolene + diphosphate"}
{"X":30182,"RHEA_ID":28270,"DIRECTION":"UN","MASTER_ID":28270,"ec":"2.3.1.57","compounds":"acetyl-CoA + spermidine = CoA + H(+) + N(8)-acetylspermidine"}
{"X":30183,"RHEA_ID":28271,"DIRECTION":"LR","MASTER_ID":28270,"ecocyc":"RXN0-7165","metacyc":"RXN0-7165","compounds":"acetyl-CoA + spermidine => CoA + H(+) + N(8)-acetylspermidine"}
{"X":30184,"RHEA_ID":28272,"compounds":"CoA + H(+) + N(8)-acetylspermidine => acetyl-CoA + spermidine"}
{"X":30185,"RHEA_ID":28273,"compounds":"acetyl-CoA + spermidine <=> CoA + H(+) + N(8)-acetylspermidine"}
{"X":30186,"RHEA_ID":28274,"compounds":"(S)-S-adenosyl-L-methionine = (R)-S-adenosyl-L-methionine"}
{"X":30187,"RHEA_ID":28275,"compounds":"(S)-S-adenosyl-L-methionine => (R)-S-adenosyl-L-methionine"}
{"X":30188,"RHEA_ID":38135,"compounds":"(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA"}
{"X":30189,"RHEA_ID":28277,"compounds":"(S)-S-adenosyl-L-methionine <=> (R)-S-adenosyl-L-methionine"}
{"X":30190,"RHEA_ID":28278,"compounds":"3-sulfino-L-alanine + H2O = H(+) + L-alanine + sulfite"}
{"X":30191,"RHEA_ID":28279,"compounds":"3-sulfino-L-alanine + H2O => H(+) + L-alanine + sulfite"}
{"X":30192,"RHEA_ID":38139,"compounds":"(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerol + CoA"}
{"X":30193,"RHEA_ID":28282,"DIRECTION":"UN","MASTER_ID":28282,"ec":"5.5.1.17","compounds":"(S)-beta-bisabolene = (S)-beta-macrocarpene"}
{"X":30194,"RHEA_ID":28283,"DIRECTION":"LR","MASTER_ID":28282,"metacyc":"RXN-11903","compounds":"(S)-beta-bisabolene => (S)-beta-macrocarpene"}
{"X":30195,"RHEA_ID":28284,"compounds":"(S)-beta-macrocarpene => (S)-beta-bisabolene"}
{"X":30196,"RHEA_ID":38144,"compounds":"carbon disulfide + 2 H2O => CO2 + 2 H(+) + 2 hydrogen sulfide"}
{"X":30197,"RHEA_ID":28286,"DIRECTION":"UN","MASTER_ID":28286,"ec":"2.1.1.201","compounds":"a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine"}
{"X":30198,"RHEA_ID":28287,"DIRECTION":"LR","MASTER_ID":28286,"metacyc":"RXN-11754","compounds":"a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine => a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine"}
{"X":30199,"RHEA_ID":28288,"compounds":"a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine => a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine"}
{"X":30200,"RHEA_ID":38148,"DIRECTION":"LR","MASTER_ID":38147,"metacyc":"RXN-2189","compounds":"carbon disulfide + H2O => carbonyl sulfide + H(+) + hydrogen sulfide"}
{"X":30201,"RHEA_ID":28290,"DIRECTION":"UN","MASTER_ID":28290,"ec":"4.2.3.194","compounds":"(2E,6E)-farnesyl diphosphate + H2O = (5S,9S,10S)-drim-7-en-11-ol + diphosphate"}
{"X":30202,"RHEA_ID":28291,"DIRECTION":"LR","MASTER_ID":28290,"metacyc":"RXN-11900","compounds":"(2E,6E)-farnesyl diphosphate + H2O => (5S,9S,10S)-drim-7-en-11-ol + diphosphate"}
{"X":30203,"RHEA_ID":38151,"DIRECTION":"UN","MASTER_ID":38151,"ec":"3.13.1.7","compounds":"carbonyl sulfide + H2O = CO2 + H(+) + hydrogen sulfide"}
{"X":30204,"RHEA_ID":38152,"DIRECTION":"LR","MASTER_ID":38151,"metacyc":"RXN-1901","compounds":"carbonyl sulfide + H2O => CO2 + H(+) + hydrogen sulfide"}
{"X":30205,"RHEA_ID":28294,"DIRECTION":"UN","MASTER_ID":28294,"ec":"4.2.3.57","compounds":"(2E,6E)-farnesyl diphosphate = (-)-beta-caryophyllene + diphosphate"}
{"X":30206,"RHEA_ID":28295,"DIRECTION":"LR","MASTER_ID":28294,"metacyc":"RXN-8414","compounds":"(2E,6E)-farnesyl diphosphate => (-)-beta-caryophyllene + diphosphate"}
{"X":30207,"RHEA_ID":38155,"DIRECTION":"UN","MASTER_ID":38155,"ec":"4.2.3.144","compounds":"all-trans-geranylgeranyl diphosphate + H2O = (6E,10E)-geranyllinalool + diphosphate"}
{"X":30208,"RHEA_ID":38156,"DIRECTION":"LR","MASTER_ID":38155,"metacyc":"RXN-10441","compounds":"all-trans-geranylgeranyl diphosphate + H2O => (6E,10E)-geranyllinalool + diphosphate"}
{"X":30209,"RHEA_ID":28298,"DIRECTION":"UN","MASTER_ID":28298,"ec":"4.2.3.59","compounds":"(2E,6E)-farnesyl diphosphate = (E)-gamma-bisabolene + diphosphate"}
{"X":30210,"RHEA_ID":28299,"DIRECTION":"LR","MASTER_ID":28298,"metacyc":"RXN-8549","compounds":"(2E,6E)-farnesyl diphosphate => (E)-gamma-bisabolene + diphosphate"}
{"X":30211,"RHEA_ID":38159,"DIRECTION":"UN","MASTER_ID":38159,"ec":"4.2.1.145","compounds":"(2S,3S)-hydroxyarginine = (2S,3R)-capreomycidine + H2O"}
{"X":30212,"RHEA_ID":38160,"compounds":"(2S,3S)-hydroxyarginine => (2S,3R)-capreomycidine + H2O"}
{"X":30213,"RHEA_ID":28302,"DIRECTION":"UN","MASTER_ID":28302,"ec":"4.2.3.60","compounds":"(2E,6E)-farnesyl diphosphate = diphosphate + germacrene C"}
{"X":30214,"RHEA_ID":28303,"DIRECTION":"LR","MASTER_ID":28302,"metacyc":"RXN-8561","compounds":"(2E,6E)-farnesyl diphosphate => diphosphate + germacrene C"}
{"X":30215,"RHEA_ID":28304,"compounds":"diphosphate + germacrene C => (2E,6E)-farnesyl diphosphate"}
{"X":30216,"RHEA_ID":38164,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA => 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA"}
{"X":30217,"RHEA_ID":28306,"DIRECTION":"UN","MASTER_ID":28306,"ec":"2.4.1.251","compounds":"beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose = beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)"}
{"X":30218,"RHEA_ID":28307,"DIRECTION":"LR","MASTER_ID":28306,"metacyc":"RXN-11789","compounds":"beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose => beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)"}
{"X":30219,"RHEA_ID":38167,"compounds":"hexadecan-1-ol + hexadecanoyl-CoA = CoA + hexadecanyl hexadecanoate"}
{"X":30220,"RHEA_ID":38168,"DIRECTION":"LR","MASTER_ID":38167,"reactome":"R-HSA-8848582.3","compounds":"hexadecan-1-ol + hexadecanoyl-CoA => CoA + hexadecanyl hexadecanoate"}
{"X":30221,"RHEA_ID":28310,"DIRECTION":"UN","MASTER_ID":28310,"ec":"2.4.1.252","compounds":"beta-D-Glc-(1->4)-alpha-D-Glc-1-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)"}
{"X":30222,"RHEA_ID":28311,"DIRECTION":"LR","MASTER_ID":28310,"metacyc":"RXN-11788","compounds":"beta-D-Glc-(1->4)-alpha-D-Glc-1-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose => alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)"}
{"X":30223,"RHEA_ID":38171,"compounds":"hexadecane-1,2-diol + hexadecanoyl-CoA = 2-hydroxyhexadecyl hexadecanoate + CoA"}
{"X":30224,"RHEA_ID":38172,"compounds":"hexadecane-1,2-diol + hexadecanoyl-CoA => 2-hydroxyhexadecyl hexadecanoate + CoA"}
{"X":30225,"RHEA_ID":28314,"DIRECTION":"UN","MASTER_ID":28314,"ec":"2.4.1.253","compounds":"baicalein + UDP-alpha-D-glucuronate = baicalin + UDP"}
{"X":30226,"RHEA_ID":28315,"DIRECTION":"LR","MASTER_ID":28314,"metacyc":"RXN-11755","compounds":"baicalein + UDP-alpha-D-glucuronate => baicalin + UDP"}
{"X":30227,"RHEA_ID":38175,"compounds":"all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl hexadecanoate + CoA"}
{"X":30228,"RHEA_ID":38176,"DIRECTION":"LR","MASTER_ID":38175,"reactome":"R-HSA-8848585.3","compounds":"all-trans-retinol + hexadecanoyl-CoA => all-trans-retinyl hexadecanoate + CoA"}
{"X":30229,"RHEA_ID":28318,"DIRECTION":"UN","MASTER_ID":28318,"ec":"2.4.1.253","compounds":"scutellarein + UDP-alpha-D-glucuronate = scutellarin + UDP"}
{"X":30230,"RHEA_ID":28319,"compounds":"scutellarein + UDP-alpha-D-glucuronate => scutellarin + UDP"}
{"X":30231,"RHEA_ID":38179,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 19-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":30232,"RHEA_ID":28321,"DIRECTION":"BI","MASTER_ID":28318,"metacyc":"RXN-14058","compounds":"scutellarein + UDP-alpha-D-glucuronate <=> scutellarin + UDP"}
{"X":30233,"RHEA_ID":28322,"DIRECTION":"UN","MASTER_ID":28322,"ec":"2.4.1.253","compounds":"UDP-alpha-D-glucuronate + wogonin = UDP + wogonin 7-O-beta-D-glucuronate"}
{"X":30234,"RHEA_ID":28323,"DIRECTION":"LR","MASTER_ID":28322,"metacyc":"RXN-14060","compounds":"UDP-alpha-D-glucuronate + wogonin => UDP + wogonin 7-O-beta-D-glucuronate"}
{"X":30235,"RHEA_ID":38183,"compounds":"19-hydroxytestosterone + O2 + reduced [NADPH--hemoprotein reductase] = 19-oxotestosterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":30236,"RHEA_ID":28325,"compounds":"UDP-alpha-D-glucuronate + wogonin <=> UDP + wogonin 7-O-beta-D-glucuronate"}
{"X":30237,"RHEA_ID":28326,"DIRECTION":"UN","MASTER_ID":28326,"ec":"3.2.1.167","compounds":"H2O + wogonin 7-O-beta-D-glucuronate = D-glucuronate + H(+) + wogonin"}
{"X":30238,"RHEA_ID":28327,"compounds":"H2O + wogonin 7-O-beta-D-glucuronate => D-glucuronate + H(+) + wogonin"}
{"X":30239,"RHEA_ID":38187,"compounds":"19-oxotestosterone + O2 + reduced [NADPH--hemoprotein reductase] = 17beta-estradiol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":30240,"RHEA_ID":28329,"compounds":"H2O + wogonin 7-O-beta-D-glucuronate <=> D-glucuronate + H(+) + wogonin"}
{"X":30241,"RHEA_ID":28330,"compounds":"H2O + ITP = H(+) + IDP + phosphate"}
{"X":30242,"RHEA_ID":28331,"DIRECTION":"LR","MASTER_ID":28330,"ecocyc":"RXN0-5073","metacyc":"RXN0-5073","compounds":"H2O + ITP => H(+) + IDP + phosphate"}
{"X":30243,"RHEA_ID":38191,"DIRECTION":"UN","MASTER_ID":38191,"ec":"1.14.14.14","compounds":"3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone = 17beta-estradiol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}
{"X":30244,"RHEA_ID":38192,"DIRECTION":"LR","MASTER_ID":38191,"metacyc":"RXN-14744","compounds":"3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone => 17beta-estradiol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}
{"X":30245,"RHEA_ID":28334,"DIRECTION":"UN","MASTER_ID":28334,"ec":"3.6.1.9","compounds":"dATP + H2O = dAMP + diphosphate + H(+)"}
{"X":30246,"RHEA_ID":28335,"DIRECTION":"LR","MASTER_ID":28334,"ecocyc":"RXN0-384","metacyc":"RXN0-384","compounds":"dATP + H2O => dAMP + diphosphate + H(+)"}
{"X":30247,"RHEA_ID":38195,"DIRECTION":"UN","MASTER_ID":38195,"ec":"1.14.14.14","compounds":"androst-4-ene-3,17-dione + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = estrone + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}
{"X":30248,"RHEA_ID":28337,"compounds":"dATP + H2O <=> dAMP + diphosphate + H(+)"}
{"X":30249,"RHEA_ID":28338,"DIRECTION":"UN","MASTER_ID":28338,"ec":"4.2.1.149","compounds":"(R)-carnitinyl-CoA = crotonobetainyl-CoA + H2O"}
{"X":30250,"RHEA_ID":28339,"DIRECTION":"LR","MASTER_ID":28338,"ecocyc":"RXN0-3561","metacyc":"RXN0-3561","compounds":"(R)-carnitinyl-CoA => crotonobetainyl-CoA + H2O"}
{"X":30251,"RHEA_ID":38199,"compounds":"androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":30252,"RHEA_ID":28341,"DIRECTION":"BI","MASTER_ID":28338,"metacyc":"CARNDETRU-RXN","compounds":"(R)-carnitinyl-CoA <=> crotonobetainyl-CoA + H2O"}
{"X":30253,"RHEA_ID":28342,"DIRECTION":"UN","MASTER_ID":28342,"ec":"3.6.1.66","compounds":"dITP + H2O = dIMP + diphosphate + H(+)"}
{"X":30254,"RHEA_ID":28342,"DIRECTION":"UN","MASTER_ID":28342,"ec":"3.6.1.9","compounds":"dITP + H2O = dIMP + diphosphate + H(+)"}
{"X":30255,"RHEA_ID":38203,"compounds":"19-hydroxyandrost-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] = 19-oxo-androst-4-ene-3,17-dione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":30256,"RHEA_ID":28344,"compounds":"dIMP + diphosphate + H(+) => dITP + H2O"}
{"X":30257,"RHEA_ID":38205,"compounds":"19-oxo-androst-4-ene-3,17-dione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 19-hydroxyandrost-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":30258,"RHEA_ID":28346,"DIRECTION":"UN","MASTER_ID":28346,"ec":"5.1.99.7","compounds":"7,8-dihydroneopterin 3'-triphosphate = 7,8-dihydromonapterin 3'-triphosphate"}
{"X":30259,"RHEA_ID":38207,"compounds":"19-oxo-androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] = estrone + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":30260,"RHEA_ID":28348,"compounds":"7,8-dihydromonapterin 3'-triphosphate => 7,8-dihydroneopterin 3'-triphosphate"}
{"X":30261,"RHEA_ID":28349,"DIRECTION":"BI","MASTER_ID":28346,"ecocyc":"H2NTPEPIM-RXN","metacyc":"H2NTPEPIM-RXN","compounds":"7,8-dihydroneopterin 3'-triphosphate <=> 7,8-dihydromonapterin 3'-triphosphate"}
{"X":30262,"RHEA_ID":28350,"DIRECTION":"UN","MASTER_ID":28350,"ec":"5.4.99.30","compounds":"UDP-beta-L-arabinofuranose = UDP-beta-L-arabinopyranose"}
{"X":30263,"RHEA_ID":38211,"compounds":"hexadecane-1,2-diol + 2 hexadecanoyl-CoA = 1,2-O,O-dihexadecanoyl-1,2-hexadecanediol + 2 CoA"}
{"X":30264,"RHEA_ID":28352,"compounds":"UDP-beta-L-arabinopyranose => UDP-beta-L-arabinofuranose"}
{"X":30265,"RHEA_ID":28353,"DIRECTION":"BI","MASTER_ID":28350,"metacyc":"RXN-11552","compounds":"UDP-beta-L-arabinofuranose <=> UDP-beta-L-arabinopyranose"}
{"X":30266,"RHEA_ID":28354,"compounds":"decanoyl-CoA + FAD + H(+) = (2E)-decenoyl-CoA + FADH2"}
{"X":30267,"RHEA_ID":28355,"DIRECTION":"LR","MASTER_ID":28354,"reactome":"R-HSA-77345.2","compounds":"decanoyl-CoA + FAD + H(+) => (2E)-decenoyl-CoA + FADH2"}
{"X":30268,"RHEA_ID":28356,"compounds":"(2E)-decenoyl-CoA + FADH2 => decanoyl-CoA + FAD + H(+)"}
{"X":30269,"RHEA_ID":38216,"DIRECTION":"LR","MASTER_ID":38215,"metacyc":"RXN-16652","compounds":"D-glucose 6-phosphate + NAD(+) => 6-phospho-D-glucono-1,5-lactone + H(+) + NADH"}
{"X":30270,"RHEA_ID":28358,"compounds":"FAD + H(+) + tetradecanoyl-CoA = (2E)-tetradecenoyl-CoA + FADH2"}
{"X":30271,"RHEA_ID":38218,"compounds":"D-glucose 6-phosphate + NAD(+) <=> 6-phospho-D-glucono-1,5-lactone + H(+) + NADH"}
{"X":30272,"RHEA_ID":28360,"compounds":"(2E)-tetradecenoyl-CoA + FADH2 => FAD + H(+) + tetradecanoyl-CoA"}
{"X":30273,"RHEA_ID":38220,"compounds":"(9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA"}
{"X":30274,"RHEA_ID":28362,"DIRECTION":"UN","MASTER_ID":28362,"ec":"3.6.1.9","compounds":"dGTP + H2O = dGMP + diphosphate + H(+)"}
{"X":30275,"RHEA_ID":38222,"compounds":"(9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA"}
{"X":30276,"RHEA_ID":28364,"compounds":"dGMP + diphosphate + H(+) => dGTP + H2O"}
{"X":30277,"RHEA_ID":38224,"compounds":"(9Z)-octadecenoyl-CoA + decan-1-ol => 1-O-decyl-(9Z)-octadecenoate + CoA"}
{"X":30278,"RHEA_ID":28366,"DIRECTION":"UN","MASTER_ID":28366,"ec":"2.4.1.180","compounds":"N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UDP-N-acetyl-alpha-D-mannosaminouronate = beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-1-diphospho-di-trans,octa-cis-undecaprenol + H(+) + UDP"}
{"X":30279,"RHEA_ID":28367,"DIRECTION":"LR","MASTER_ID":28366,"ecocyc":"UDPMANACATRANS-RXN","metacyc":"UDPMANACATRANS-RXN","compounds":"N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UDP-N-acetyl-alpha-D-mannosaminouronate => beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-1-diphospho-di-trans,octa-cis-undecaprenol + H(+) + UDP"}
{"X":30280,"RHEA_ID":28368,"compounds":"beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-1-diphospho-di-trans,octa-cis-undecaprenol + H(+) + UDP => N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UDP-N-acetyl-alpha-D-mannosaminouronate"}
{"X":30281,"RHEA_ID":38228,"compounds":"(9Z)-octadecenoyl-CoA + hexadecan-1-ol => CoA + hexadecanyl (9Z)-octadecenoate"}
{"X":30282,"RHEA_ID":28370,"DIRECTION":"UN","MASTER_ID":28370,"ec":"4.1.1.31","compounds":"oxaloacetate + phosphate = hydrogencarbonate + phosphoenolpyruvate"}
{"X":30283,"RHEA_ID":28371,"compounds":"oxaloacetate + phosphate => hydrogencarbonate + phosphoenolpyruvate"}
{"X":30284,"RHEA_ID":38231,"compounds":"(9Z)-hexadecen-1-ol + (9Z)-octadecenoyl-CoA = 1-O-(9Z)-hexadecenyl (9Z)-octadecenoate + CoA"}
{"X":30285,"RHEA_ID":28373,"compounds":"oxaloacetate + phosphate <=> hydrogencarbonate + phosphoenolpyruvate"}
{"X":30286,"RHEA_ID":28374,"compounds":"ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine"}
{"X":30287,"RHEA_ID":28375,"DIRECTION":"LR","MASTER_ID":28374,"ecocyc":"UDP-NACMURALGLDAPAALIG-RXN","metacyc":"UDP-NACMURALGLDAPAALIG-RXN","compounds":"ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine"}
{"X":30288,"RHEA_ID":28376,"compounds":"ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine => ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate"}
{"X":30289,"RHEA_ID":48150,"compounds":"ganglioside GD1b(d18:1(4E)/18:0) + N-acetylneuraminate => ganglioside GT1b (d18:1(4E)/18:0) + H2O"}
{"X":30290,"RHEA_ID":28378,"DIRECTION":"UN","MASTER_ID":28378,"ec":"2.7.1.218","compounds":"ATP + N(6)-(D-fructosyl)-L-lysine = ADP + H(+) + N(6)-(6-phospho-D-fructosyl)-L-lysine"}
{"X":30291,"RHEA_ID":28379,"DIRECTION":"LR","MASTER_ID":28378,"ecocyc":"RXN0-962","metacyc":"RXN0-962","compounds":"ATP + N(6)-(D-fructosyl)-L-lysine => ADP + H(+) + N(6)-(6-phospho-D-fructosyl)-L-lysine"}
{"X":30292,"RHEA_ID":28380,"compounds":"ADP + H(+) + N(6)-(6-phospho-D-fructosyl)-L-lysine => ATP + N(6)-(D-fructosyl)-L-lysine"}
{"X":30293,"RHEA_ID":48154,"compounds":"ganglioside GM1 (d18:1(4E)/18:0) + N-acetylneuraminate => ganglioside GD1b(d18:1(4E)/18:0) + H2O"}
{"X":30294,"RHEA_ID":28382,"compounds":"H2O + N(6)-(6-phospho-D-fructosyl)-L-lysine = D-glucose 6-phosphate + L-lysine"}
{"X":30295,"RHEA_ID":28383,"compounds":"H2O + N(6)-(6-phospho-D-fructosyl)-L-lysine => D-glucose 6-phosphate + L-lysine"}
{"X":30296,"RHEA_ID":28384,"compounds":"D-glucose 6-phosphate + L-lysine => H2O + N(6)-(6-phospho-D-fructosyl)-L-lysine"}
{"X":30297,"RHEA_ID":48158,"compounds":"ganglioside GT1b (d18:1(4E)) + N-acetylneuraminate => ganglioside GQ1b (d18:1(4E)) + H2O"}
{"X":30298,"RHEA_ID":28386,"compounds":"di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine-diphosphoundecaprenol + UMP"}
{"X":30299,"RHEA_ID":28387,"DIRECTION":"LR","MASTER_ID":28386,"ecocyc":"PHOSNACMURPENTATRANS-RXN","metacyc":"PHOSNACMURPENTATRANS-RXN","compounds":"di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine => N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine-diphosphoundecaprenol + UMP"}
{"X":30300,"RHEA_ID":28388,"compounds":"N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine-diphosphoundecaprenol + UMP => di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine"}
{"X":30301,"RHEA_ID":48162,"compounds":"epoxypheophorbide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 3 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":30302,"RHEA_ID":28390,"DIRECTION":"UN","MASTER_ID":28390,"ec":"5.1.3.41","compounds":"N(6)-(D-psicosyl)-L-lysine = N(6)-(D-fructosyl)-L-lysine"}
{"X":30303,"RHEA_ID":28391,"compounds":"N(6)-(D-psicosyl)-L-lysine => N(6)-(D-fructosyl)-L-lysine"}
{"X":30304,"RHEA_ID":28392,"compounds":"N(6)-(D-fructosyl)-L-lysine => N(6)-(D-psicosyl)-L-lysine"}
{"X":30305,"RHEA_ID":48166,"compounds":"H(+) + red chlorophyll catabolite => epoxypheophorbide a + H2O"}
{"X":30306,"RHEA_ID":28394,"DIRECTION":"UN","MASTER_ID":28394,"ec":"5.1.1.20","compounds":"L-alanyl-L-glutamate = L-alanyl-D-glutamate"}
{"X":30307,"RHEA_ID":28395,"compounds":"L-alanyl-L-glutamate => L-alanyl-D-glutamate"}
{"X":30308,"RHEA_ID":28396,"compounds":"L-alanyl-D-glutamate => L-alanyl-L-glutamate"}
{"X":30309,"RHEA_ID":38256,"compounds":"(S)-malate + succinyl-CoA => (S)-malyl-CoA + succinate"}
{"X":30310,"RHEA_ID":28398,"compounds":"H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate = L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate"}
{"X":30311,"RHEA_ID":28399,"DIRECTION":"LR","MASTER_ID":28398,"ecocyc":"RXN0-961","metacyc":"RXN0-961","compounds":"H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate => L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate"}
{"X":30312,"RHEA_ID":28400,"compounds":"L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate => H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate"}
{"X":30313,"RHEA_ID":38260,"compounds":"(2R,3S)-beta-methylmalyl-CoA => glyoxylate + propanoyl-CoA"}
{"X":30314,"RHEA_ID":28402,"compounds":"ADP-L-glycero-beta-D-manno-heptose + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A = ADP + H(+) + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A"}
{"X":30315,"RHEA_ID":28403,"DIRECTION":"LR","MASTER_ID":28402,"ecocyc":"RXN0-5118","metacyc":"RXN0-5118","compounds":"ADP-L-glycero-beta-D-manno-heptose + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A => ADP + H(+) + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A"}
{"X":30316,"RHEA_ID":28404,"compounds":"ADP + H(+) + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A => ADP-L-glycero-beta-D-manno-heptose + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A"}
{"X":30317,"RHEA_ID":38264,"compounds":"(2R,3S)-beta-methylmalyl-CoA => 2-methylfumaryl-CoA + H2O"}
{"X":30318,"RHEA_ID":38265,"compounds":"2-methylfumaryl-CoA + H2O => (2R,3S)-beta-methylmalyl-CoA"}
{"X":30319,"RHEA_ID":28407,"DIRECTION":"LR","MASTER_ID":28406,"ecocyc":"RXN0-5074","metacyc":"RXN0-5074","compounds":"H2O + XTP => H(+) + phosphate + XDP"}
{"X":30320,"RHEA_ID":28408,"compounds":"H(+) + phosphate + XDP => H2O + XTP"}
{"X":30321,"RHEA_ID":28409,"compounds":"H2O + XTP <=> H(+) + phosphate + XDP"}
{"X":30322,"RHEA_ID":38269,"compounds":"3-methylfumaryl-CoA => 2-methylfumaryl-CoA"}
{"X":30323,"RHEA_ID":28411,"DIRECTION":"LR","MASTER_ID":28410,"ecocyc":"RXN0-3922","metacyc":"RXN0-3922","compounds":"4-(gamma-L-glutamylamino)butanal + H2O + NADP(+) => 4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADPH"}
{"X":30324,"RHEA_ID":28412,"compounds":"4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADPH => 4-(gamma-L-glutamylamino)butanal + H2O + NADP(+)"}
{"X":30325,"RHEA_ID":38272,"compounds":"(3S)-citramalyl-CoA => 3-methylfumaryl-CoA + H2O"}
{"X":30326,"RHEA_ID":28414,"compounds":"gamma-L-glutamylputrescine + H2O + O2 = 4-(gamma-L-glutamylamino)butanal + H2O2 + NH4(+)"}
{"X":30327,"RHEA_ID":28415,"DIRECTION":"LR","MASTER_ID":28414,"ecocyc":"RXN0-3921","metacyc":"RXN0-3921","compounds":"gamma-L-glutamylputrescine + H2O + O2 => 4-(gamma-L-glutamylamino)butanal + H2O2 + NH4(+)"}
{"X":30328,"RHEA_ID":28416,"compounds":"4-(gamma-L-glutamylamino)butanal + H2O2 + NH4(+) => gamma-L-glutamylputrescine + H2O + O2"}
{"X":30329,"RHEA_ID":38276,"compounds":"(3R)-citramalyl-CoA => acetyl-CoA + pyruvate"}
{"X":30330,"RHEA_ID":38277,"compounds":"acetyl-CoA + pyruvate => (3R)-citramalyl-CoA"}
{"X":30331,"RHEA_ID":28419,"DIRECTION":"LR","MASTER_ID":28418,"ecocyc":"RXN0-3601","metacyc":"RXN0-3601","compounds":"(R)-carnitine + gamma-butyrobetainyl-CoA => (R)-carnitinyl-CoA + 4-(trimethylamino)butanoate"}
{"X":30332,"RHEA_ID":28420,"compounds":"(R)-carnitinyl-CoA + 4-(trimethylamino)butanoate => (R)-carnitine + gamma-butyrobetainyl-CoA"}
{"X":30333,"RHEA_ID":28421,"compounds":"(R)-carnitine + gamma-butyrobetainyl-CoA <=> (R)-carnitinyl-CoA + 4-(trimethylamino)butanoate"}
{"X":30334,"RHEA_ID":28422,"DIRECTION":"UN","MASTER_ID":28422,"ec":"1.14.14.41","compounds":"(1E,2S)-2-methylbutanal oxime + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-2-methylbutanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":30335,"RHEA_ID":48196,"compounds":"H(+) + heptadecanoyl-CoA + oxidized [electron-transfer flavoprotein] = reduced [electron-transfer flavoprotein] + trans-2-heptadecenoyl-CoA"}
{"X":30336,"RHEA_ID":28424,"compounds":"2-hydroxy-2-methylbutanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (1E,2S)-2-methylbutanal oxime + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":30337,"RHEA_ID":28426,"compounds":"D-allulose 6-phosphate = keto-D-fructose 6-phosphate"}
{"X":30338,"RHEA_ID":48200,"compounds":"H(+) + oxidized [electron-transfer flavoprotein] + undecanoyl-CoA = reduced [electron-transfer flavoprotein] + trans-2-undecenoyl-CoA"}
{"X":30339,"RHEA_ID":28428,"compounds":"keto-D-fructose 6-phosphate => D-allulose 6-phosphate"}
{"X":30340,"RHEA_ID":38288,"compounds":"(3S)-citramalate + succinyl-CoA => (3S)-citramalyl-CoA + succinate"}
{"X":30341,"RHEA_ID":28430,"compounds":"D-allose 6-phosphate = D-allulose 6-phosphate"}
{"X":30342,"RHEA_ID":28431,"compounds":"D-allose 6-phosphate => D-allulose 6-phosphate"}
{"X":30343,"RHEA_ID":28432,"compounds":"D-allulose 6-phosphate => D-allose 6-phosphate"}
{"X":30344,"RHEA_ID":38292,"DIRECTION":"LR","MASTER_ID":38291,"metacyc":"RXN-14937","compounds":"(S)-malyl-CoA + H2O => (S)-malate + CoA + H(+)"}
{"X":30345,"RHEA_ID":28434,"compounds":"(9Z)-hexadecenoyl-(Kdo)2-lipid IVA + tetradecanoyl-[ACP] = ((9Z)-hexadecenoyl-tetradecanoyl)-(Kdo)2-lipid A + holo-[ACP]"}
{"X":30346,"RHEA_ID":48208,"compounds":"H(+) + nonanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-nonenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":30347,"RHEA_ID":28436,"compounds":"((9Z)-hexadecenoyl-tetradecanoyl)-(Kdo)2-lipid A + holo-[ACP] => (9Z)-hexadecenoyl-(Kdo)2-lipid IVA + tetradecanoyl-[ACP]"}
{"X":30348,"RHEA_ID":28437,"compounds":"(9Z)-hexadecenoyl-(Kdo)2-lipid IVA + tetradecanoyl-[ACP] <=> ((9Z)-hexadecenoyl-tetradecanoyl)-(Kdo)2-lipid A + holo-[ACP]"}
{"X":30349,"RHEA_ID":28438,"DIRECTION":"UN","MASTER_ID":28438,"ec":"2.3.1.243","compounds":"dodecanoyl-(Kdo)2-lipid IVA + tetradecanoyl-[ACP] = alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + holo-[ACP]"}
{"X":30350,"RHEA_ID":48212,"compounds":"a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O = a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + N-acetyl-alpha-D-galactosamine"}
{"X":30351,"RHEA_ID":28440,"compounds":"alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + holo-[ACP] => dodecanoyl-(Kdo)2-lipid IVA + tetradecanoyl-[ACP]"}
{"X":30352,"RHEA_ID":28442,"DIRECTION":"UN","MASTER_ID":28442,"ec":"2.3.1.241","compounds":"alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + dodecanoyl-[ACP] = dodecanoyl-(Kdo)2-lipid IVA + holo-[ACP]"}
{"X":30353,"RHEA_ID":38302,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA <=> 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA"}
{"X":30354,"RHEA_ID":28444,"compounds":"dodecanoyl-(Kdo)2-lipid IVA + holo-[ACP] => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + dodecanoyl-[ACP]"}
{"X":30355,"RHEA_ID":28446,"compounds":"1-deoxy-D-xylulose(in) = 1-deoxy-D-xylulose(out)"}
{"X":30356,"RHEA_ID":48220,"compounds":"H(+) + oxidized [electron-transfer flavoprotein] + tricosanoyl-CoA = (2E)-tricosenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":30357,"RHEA_ID":28448,"DIRECTION":"RL","MASTER_ID":28446,"ecocyc":"TRANS-RXN0-448","compounds":"1-deoxy-D-xylulose(out) => 1-deoxy-D-xylulose(in)"}
{"X":30358,"RHEA_ID":28449,"compounds":"1-deoxy-D-xylulose(in) <=> 1-deoxy-D-xylulose(out)"}
{"X":30359,"RHEA_ID":28450,"compounds":"N(6)-(D-psicosyl)-L-lysine(in) = N(6)-(D-psicosyl)-L-lysine(out)"}
{"X":30360,"RHEA_ID":38310,"compounds":"(9Z)-octadecenoyl-CoA + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA"}
{"X":30361,"RHEA_ID":28452,"DIRECTION":"RL","MASTER_ID":28450,"ecocyc":"TRANS-RXN0-418","compounds":"N(6)-(D-psicosyl)-L-lysine(out) => N(6)-(D-psicosyl)-L-lysine(in)"}
{"X":30362,"RHEA_ID":28453,"compounds":"N(6)-(D-psicosyl)-L-lysine(in) <=> N(6)-(D-psicosyl)-L-lysine(out)"}
{"X":30363,"RHEA_ID":28454,"compounds":"N(6)-(D-fructosyl)-L-lysine(in) = N(6)-(D-fructosyl)-L-lysine(out)"}
{"X":30364,"RHEA_ID":28455,"compounds":"N(6)-(D-fructosyl)-L-lysine(in) => N(6)-(D-fructosyl)-L-lysine(out)"}
{"X":30365,"RHEA_ID":28456,"DIRECTION":"RL","MASTER_ID":28454,"ecocyc":"TRANS-RXN0-417","compounds":"N(6)-(D-fructosyl)-L-lysine(out) => N(6)-(D-fructosyl)-L-lysine(in)"}
{"X":30366,"RHEA_ID":28457,"compounds":"N(6)-(D-fructosyl)-L-lysine(in) <=> N(6)-(D-fructosyl)-L-lysine(out)"}
{"X":30367,"RHEA_ID":28458,"compounds":"biotin(in) = biotin(out)"}
{"X":30368,"RHEA_ID":48232,"DIRECTION":"UN","MASTER_ID":48232,"ec":"2.3.1.271","compounds":"acetyl-CoA + L-glutamate 5-semialdehyde = CoA + H(+) + N-acetyl-L-glutamate 5-semialdehyde"}
{"X":30369,"RHEA_ID":28460,"DIRECTION":"RL","MASTER_ID":28458,"ecocyc":"TRANS-RXN0-240","metacyc":"TRANS-RXN0-240","compounds":"biotin(out) => biotin(in)"}
{"X":30370,"RHEA_ID":28461,"compounds":"biotin(in) <=> biotin(out)"}
{"X":30371,"RHEA_ID":28462,"compounds":"pyridoxal(in) = pyridoxal(out)"}
{"X":30372,"RHEA_ID":28463,"compounds":"pyridoxal(in) => pyridoxal(out)"}
{"X":30373,"RHEA_ID":28464,"DIRECTION":"RL","MASTER_ID":28462,"ecocyc":"TRANS-RXN0-214","compounds":"pyridoxal(out) => pyridoxal(in)"}
{"X":30374,"RHEA_ID":38324,"compounds":"2 1-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-glycerol + glycerol"}
{"X":30375,"RHEA_ID":28466,"compounds":"pyridoxamine(in) = pyridoxamine(out)"}
{"X":30376,"RHEA_ID":28467,"compounds":"pyridoxamine(in) => pyridoxamine(out)"}
{"X":30377,"RHEA_ID":28468,"DIRECTION":"RL","MASTER_ID":28466,"ecocyc":"TRANS-RXN0-213","compounds":"pyridoxamine(out) => pyridoxamine(in)"}
{"X":30378,"RHEA_ID":28469,"compounds":"pyridoxamine(in) <=> pyridoxamine(out)"}
{"X":30379,"RHEA_ID":28470,"compounds":"pyridoxine(in) = pyridoxine(out)"}
{"X":30380,"RHEA_ID":28471,"compounds":"pyridoxine(in) => pyridoxine(out)"}
{"X":30381,"RHEA_ID":28472,"DIRECTION":"RL","MASTER_ID":28470,"ecocyc":"TRANS-RXN0-205","compounds":"pyridoxine(out) => pyridoxine(in)"}
{"X":30382,"RHEA_ID":38332,"compounds":"1,3-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol"}
{"X":30383,"RHEA_ID":28474,"compounds":"D-glucarate(in) = D-glucarate(out)"}
{"X":30384,"RHEA_ID":28475,"compounds":"D-glucarate(in) => D-glucarate(out)"}
{"X":30385,"RHEA_ID":28476,"DIRECTION":"RL","MASTER_ID":28474,"ecocyc":"TRANS-RXN0-204","compounds":"D-glucarate(out) => D-glucarate(in)"}
{"X":30386,"RHEA_ID":38336,"compounds":"(20S)-ginsenoside Rb1 + 2 H2O => (20S)-ginsenoside Rg3 + 2 D-glucose"}
{"X":30387,"RHEA_ID":28478,"compounds":"galactarate(in) = galactarate(out)"}
{"X":30388,"RHEA_ID":28479,"compounds":"galactarate(in) => galactarate(out)"}
{"X":30389,"RHEA_ID":28480,"DIRECTION":"RL","MASTER_ID":28478,"ecocyc":"TRANS-RXN0-203","compounds":"galactarate(out) => galactarate(in)"}
{"X":30390,"RHEA_ID":28481,"compounds":"galactarate(in) <=> galactarate(out)"}
{"X":30391,"RHEA_ID":28482,"compounds":"beta-nicotinamide D-ribonucleotide(in) = beta-nicotinamide D-ribonucleotide(out)"}
{"X":30392,"RHEA_ID":28483,"compounds":"beta-nicotinamide D-ribonucleotide(in) => beta-nicotinamide D-ribonucleotide(out)"}
{"X":30393,"RHEA_ID":28484,"compounds":"beta-nicotinamide D-ribonucleotide(out) => beta-nicotinamide D-ribonucleotide(in)"}
{"X":30394,"RHEA_ID":38344,"compounds":"(20S)-ginsenoside Rd + H2O => (20S)-ginsenoside Rg3 + D-glucose"}
{"X":30395,"RHEA_ID":28486,"compounds":"Fe(2+)(in) = Fe(2+)(out)"}
{"X":30396,"RHEA_ID":28487,"DIRECTION":"LR","MASTER_ID":28486,"reactome":"R-HSA-1362417.1","compounds":"Fe(2+)(in) => Fe(2+)(out)"}
{"X":30397,"RHEA_ID":28487,"DIRECTION":"LR","MASTER_ID":28486,"reactome":"R-HSA-917936.1","compounds":"Fe(2+)(in) => Fe(2+)(out)"}
{"X":30398,"RHEA_ID":38348,"compounds":"(S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate => 2-(3,5-dihydroxyphenyl)-2-oxoacetate + L-glutamate"}
{"X":30399,"RHEA_ID":28488,"DIRECTION":"RL","MASTER_ID":28486,"ecocyc":"TRANS-RXN-8","reactome":"R-HSA-904830.1","compounds":"Fe(2+)(out) => Fe(2+)(in)"}
{"X":30400,"RHEA_ID":28489,"compounds":"Fe(2+)(in) <=> Fe(2+)(out)"}
{"X":30401,"RHEA_ID":28490,"compounds":"H(+)(in) + K(+)(in) = H(+)(out) + K(+)(out)"}
{"X":30402,"RHEA_ID":38352,"compounds":"(R)-3-phenyllactate + NAD(+) => 3-phenylpyruvate + H(+) + NADH"}
{"X":30403,"RHEA_ID":28492,"DIRECTION":"RL","MASTER_ID":28490,"ecocyc":"TRANS-RXN-3","compounds":"H(+)(out) + K(+)(out) => H(+)(in) + K(+)(in)"}
{"X":30404,"RHEA_ID":28493,"compounds":"H(+)(in) + K(+)(in) <=> H(+)(out) + K(+)(out)"}
{"X":30405,"RHEA_ID":28494,"DIRECTION":"UN","MASTER_ID":28494,"ec":"1.8.5.3","compounds":"a menaquinone + dimethyl sulfide + H2O = a menaquinol + dimethyl sulfoxide"}
{"X":30406,"RHEA_ID":38356,"DIRECTION":"LR","MASTER_ID":38355,"metacyc":"RXN-19883","compounds":"(R)-3-phenyllactoyl-CoA => (E)-cinnamoyl-CoA + H2O"}
{"X":30407,"RHEA_ID":28496,"DIRECTION":"RL","MASTER_ID":28494,"ecocyc":"DIMESULFREDUCT-RXN","metacyc":"DIMESULFREDUCT-RXN","compounds":"a menaquinol + dimethyl sulfoxide => a menaquinone + dimethyl sulfide + H2O"}
{"X":30408,"RHEA_ID":28497,"compounds":"a menaquinone + dimethyl sulfide + H2O <=> a menaquinol + dimethyl sulfoxide"}
{"X":30409,"RHEA_ID":28498,"compounds":"formaldehyde + mycothiol = S-(hydroxymethyl)mycothiol"}
{"X":30410,"RHEA_ID":38360,"compounds":"2 H(+) + hydrogen sulfide + sulfite + ubiquinone-10 => thiosulfate + ubiquinol-10"}
{"X":30411,"RHEA_ID":28500,"compounds":"S-(hydroxymethyl)mycothiol => formaldehyde + mycothiol"}
{"X":30412,"RHEA_ID":28501,"compounds":"formaldehyde + mycothiol <=> S-(hydroxymethyl)mycothiol"}
{"X":30413,"RHEA_ID":28502,"DIRECTION":"UN","MASTER_ID":28502,"ec":"1.1.1.306","compounds":"NAD(+) + S-(hydroxymethyl)mycothiol = H(+) + NADH + S-formylmycothiol"}
{"X":30414,"RHEA_ID":38364,"compounds":"1-octadecanoylglycerol + H2O => glycerol + H(+) + octadecanoate"}
{"X":30415,"RHEA_ID":28504,"compounds":"H(+) + NADH + S-formylmycothiol => NAD(+) + S-(hydroxymethyl)mycothiol"}
{"X":30416,"RHEA_ID":38366,"compounds":"1-octadecanoylglycerol + H2O <=> glycerol + H(+) + octadecanoate"}
{"X":30417,"RHEA_ID":28506,"DIRECTION":"UN","MASTER_ID":28506,"ec":"2.7.1.166","compounds":"alpha-Kdo-(2->6)-lipid IVA + ATP = 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA + ADP + H(+)"}
{"X":30418,"RHEA_ID":38368,"DIRECTION":"LR","MASTER_ID":38367,"metacyc":"RXN-17985","compounds":"8 H(+) + malonamoyl-[OxyC ACP] + 8 malonyl-CoA => 18-carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[OxyC ACP] + 8 CO2 + 8 CoA"}
{"X":30419,"RHEA_ID":28508,"compounds":"4-O-phospho-alpha-Kdo-(2->6)-lipid IVA + ADP + H(+) => alpha-Kdo-(2->6)-lipid IVA + ATP"}
{"X":30420,"RHEA_ID":28509,"DIRECTION":"BI","MASTER_ID":28506,"metacyc":"RXN-11328","compounds":"alpha-Kdo-(2->6)-lipid IVA + ATP <=> 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA + ADP + H(+)"}
{"X":30421,"RHEA_ID":28510,"compounds":"arbutin 6-phosphate + H2O = beta-D-glucose 6-phosphate + hydroquinone"}
{"X":30422,"RHEA_ID":28511,"DIRECTION":"LR","MASTER_ID":28510,"ecocyc":"RXN0-5295","metacyc":"RXN0-5295","compounds":"arbutin 6-phosphate + H2O => beta-D-glucose 6-phosphate + hydroquinone"}
{"X":30423,"RHEA_ID":28512,"compounds":"beta-D-glucose 6-phosphate + hydroquinone => arbutin 6-phosphate + H2O"}
{"X":30424,"RHEA_ID":38374,"compounds":"1-(9Z-octadecenoyl)-sn-glycerol + H2O <=> (9Z)-octadecenoate + glycerol + H(+)"}
{"X":30425,"RHEA_ID":28514,"DIRECTION":"UN","MASTER_ID":28514,"ec":"6.2.1.48","compounds":"(R)-carnitine + ATP + CoA = (R)-carnitinyl-CoA + AMP + diphosphate"}
{"X":30426,"RHEA_ID":38376,"compounds":"bacterioruberin => bisanhydrobacterioruberin + 2 H2O"}
{"X":30427,"RHEA_ID":28516,"compounds":"(R)-carnitinyl-CoA + AMP + diphosphate => (R)-carnitine + ATP + CoA"}
{"X":30428,"RHEA_ID":38378,"DIRECTION":"BI","MASTER_ID":38375,"metacyc":"RXN-16711","compounds":"bacterioruberin <=> bisanhydrobacterioruberin + 2 H2O"}
{"X":30429,"RHEA_ID":28518,"DIRECTION":"UN","MASTER_ID":28518,"ec":"3.1.3.82","compounds":"D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O = D-glycero-beta-D-manno-heptose 1-phosphate + phosphate"}
{"X":30430,"RHEA_ID":38380,"compounds":"(9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H(+) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O"}
{"X":30431,"RHEA_ID":28520,"compounds":"D-glycero-beta-D-manno-heptose 1-phosphate + phosphate => D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O"}
{"X":30432,"RHEA_ID":38382,"compounds":"(9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H(+) <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O"}
{"X":30433,"RHEA_ID":28522,"DIRECTION":"UN","MASTER_ID":28522,"ec":"3.1.3.83","compounds":"D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H2O = D-glycero-alpha-D-manno-heptose 1-phosphate + phosphate"}
{"X":30434,"RHEA_ID":28523,"DIRECTION":"LR","MASTER_ID":28522,"metacyc":"RXN-11365","compounds":"D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H2O => D-glycero-alpha-D-manno-heptose 1-phosphate + phosphate"}
{"X":30435,"RHEA_ID":28524,"compounds":"D-glycero-alpha-D-manno-heptose 1-phosphate + phosphate => D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H2O"}
{"X":30436,"RHEA_ID":38386,"compounds":"2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)"}
{"X":30437,"RHEA_ID":28526,"DIRECTION":"UN","MASTER_ID":28526,"ec":"2.8.3.21","compounds":"(R)-carnitine + crotonobetainyl-CoA = (R)-carnitinyl-CoA + crotonobetaine"}
{"X":30438,"RHEA_ID":28527,"compounds":"(R)-carnitine + crotonobetainyl-CoA => (R)-carnitinyl-CoA + crotonobetaine"}
{"X":30439,"RHEA_ID":28528,"compounds":"(R)-carnitinyl-CoA + crotonobetaine => (R)-carnitine + crotonobetainyl-CoA"}
{"X":30440,"RHEA_ID":28529,"compounds":"(R)-carnitine + crotonobetainyl-CoA <=> (R)-carnitinyl-CoA + crotonobetaine"}
{"X":30441,"RHEA_ID":28530,"compounds":"H2O + XMP = phosphate + xanthosine"}
{"X":30442,"RHEA_ID":38392,"compounds":"1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+)"}
{"X":30443,"RHEA_ID":28532,"compounds":"phosphate + xanthosine => H2O + XMP"}
{"X":30444,"RHEA_ID":38394,"compounds":"1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+)"}
{"X":30445,"RHEA_ID":28534,"DIRECTION":"UN","MASTER_ID":28534,"ec":"3.6.1.9","compounds":"dTTP + H2O = diphosphate + dTMP + H(+)"}
{"X":30446,"RHEA_ID":38396,"compounds":"1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O => (9Z)-hexadecenoate + 1,3-di-(9Z)-hexadecenoylglycerol + H(+)"}
{"X":30447,"RHEA_ID":28536,"compounds":"diphosphate + dTMP + H(+) => dTTP + H2O"}
{"X":30448,"RHEA_ID":28537,"compounds":"dTTP + H2O <=> diphosphate + dTMP + H(+)"}
{"X":30449,"RHEA_ID":28538,"compounds":"ADP-L-glycero-beta-D-manno-heptose + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A = ADP + H(+) + L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A"}
{"X":30450,"RHEA_ID":28539,"DIRECTION":"LR","MASTER_ID":28538,"ecocyc":"RXN0-5061","metacyc":"RXN0-5061","compounds":"ADP-L-glycero-beta-D-manno-heptose + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A => ADP + H(+) + L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A"}
{"X":30451,"RHEA_ID":38401,"compounds":"(9Z)-hexadecenoate + 2,3-di-(9Z)-hexadecenoyl-sn-glycerol + H(+) => 1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O"}
{"X":30452,"RHEA_ID":28541,"compounds":"ADP-L-glycero-beta-D-manno-heptose + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A <=> ADP + H(+) + L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A"}
{"X":30453,"RHEA_ID":28542,"DIRECTION":"UN","MASTER_ID":28542,"ec":"3.1.2.29","compounds":"fluoroacetyl-CoA + H2O = CoA + fluoroacetate + H(+)"}
{"X":30454,"RHEA_ID":28543,"compounds":"fluoroacetyl-CoA + H2O => CoA + fluoroacetate + H(+)"}
{"X":30455,"RHEA_ID":28544,"compounds":"CoA + fluoroacetate + H(+) => fluoroacetyl-CoA + H2O"}
{"X":30456,"RHEA_ID":38406,"compounds":"1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O <=> (9Z,12Z)-octadecadienoate + 1,3-di-(9Z,12Z)-octadecadienoylglycerol + H(+)"}
{"X":30457,"RHEA_ID":28546,"DIRECTION":"UN","MASTER_ID":28546,"ec":"5.3.1.5","compounds":"D-glucose = D-fructose"}
{"X":30458,"RHEA_ID":28547,"compounds":"D-glucose => D-fructose"}
{"X":30459,"RHEA_ID":28548,"compounds":"D-fructose => D-glucose"}
{"X":30460,"RHEA_ID":38410,"compounds":"1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O <=> (9Z,12Z)-octadecadienoate + 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + H(+)"}
{"X":30461,"RHEA_ID":38411,"compounds":"1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O = (9Z,12Z,15Z)-octadecatrienoate + 1,3-di-(9Z,12Z,15Z)-octadecatrienoylglycerol + H(+)"}
{"X":30462,"RHEA_ID":28550,"compounds":"acetyl-CoA + anthranilate = CoA + N-acetylanthranilate"}
{"X":30463,"RHEA_ID":28551,"compounds":"acetyl-CoA + anthranilate => CoA + N-acetylanthranilate"}
{"X":30464,"RHEA_ID":28552,"compounds":"CoA + N-acetylanthranilate => acetyl-CoA + anthranilate"}
{"X":30465,"RHEA_ID":28553,"compounds":"acetyl-CoA + anthranilate <=> CoA + N-acetylanthranilate"}
{"X":30466,"RHEA_ID":28554,"compounds":"D-mannose 6-phosphate + H2O = D-mannose + phosphate"}
{"X":30467,"RHEA_ID":28555,"compounds":"D-mannose 6-phosphate + H2O => D-mannose + phosphate"}
{"X":30468,"RHEA_ID":38418,"compounds":"1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O <=> (9Z,12Z,15Z)-octadecatrienoate + 2,3-di-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycerol + H(+)"}
{"X":30469,"RHEA_ID":28557,"compounds":"D-mannose 6-phosphate + H2O <=> D-mannose + phosphate"}
{"X":30470,"RHEA_ID":28558,"compounds":"D-fructose 6-phosphate + H2O = D-fructose + phosphate"}
{"X":30471,"RHEA_ID":28559,"compounds":"D-fructose 6-phosphate + H2O => D-fructose + phosphate"}
{"X":30472,"RHEA_ID":28560,"compounds":"D-fructose + phosphate => D-fructose 6-phosphate + H2O"}
{"X":30473,"RHEA_ID":28561,"compounds":"D-fructose 6-phosphate + H2O <=> D-fructose + phosphate"}
{"X":30474,"RHEA_ID":38424,"compounds":"1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H(+)"}
{"X":30475,"RHEA_ID":28563,"compounds":"D-alanine + pyridoxal 5'-phosphate => pyridoxamine 5'-phosphate + pyruvate"}
{"X":30476,"RHEA_ID":28564,"compounds":"pyridoxamine 5'-phosphate + pyruvate => D-alanine + pyridoxal 5'-phosphate"}
{"X":30477,"RHEA_ID":38427,"compounds":"1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+) + hexadecanoate"}
{"X":30478,"RHEA_ID":38428,"compounds":"1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O => 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+) + hexadecanoate"}
{"X":30479,"RHEA_ID":28567,"compounds":"3 2,3-dihydroxybenzoyl-5'-AMP + 3 L-seryl-5'-AMP => 6 AMP + enterobactin + 7 H(+)"}
{"X":30480,"RHEA_ID":28568,"compounds":"6 AMP + enterobactin + 7 H(+) => 3 2,3-dihydroxybenzoyl-5'-AMP + 3 L-seryl-5'-AMP"}
{"X":30481,"RHEA_ID":28569,"DIRECTION":"BI","MASTER_ID":28566,"metacyc":"ENTG-RXN","compounds":"3 2,3-dihydroxybenzoyl-5'-AMP + 3 L-seryl-5'-AMP <=> 6 AMP + enterobactin + 7 H(+)"}
{"X":30482,"RHEA_ID":38432,"compounds":"1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O => (9Z)-octadecenoate + 2-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+)"}
{"X":30483,"RHEA_ID":28571,"DIRECTION":"LR","MASTER_ID":28570,"ecocyc":"ENTF-RXN","metacyc":"ENTF-RXN","compounds":"ATP + L-serine => diphosphate + L-seryl-5'-AMP"}
{"X":30484,"RHEA_ID":28572,"compounds":"diphosphate + L-seryl-5'-AMP => ATP + L-serine"}
{"X":30485,"RHEA_ID":28573,"compounds":"ATP + L-serine <=> diphosphate + L-seryl-5'-AMP"}
{"X":30486,"RHEA_ID":28574,"compounds":"H(+)(in) + sulfate(in) = H(+)(out) + sulfate(out)"}
{"X":30487,"RHEA_ID":28575,"compounds":"H(+)(in) + sulfate(in) => H(+)(out) + sulfate(out)"}
{"X":30488,"RHEA_ID":28576,"compounds":"H(+)(out) + sulfate(out) => H(+)(in) + sulfate(in)"}
{"X":30489,"RHEA_ID":28577,"compounds":"H(+)(in) + sulfate(in) <=> H(+)(out) + sulfate(out)"}
{"X":30490,"RHEA_ID":38440,"compounds":"(9Z)-octadecenoyl-CoA + 2,3-di-(9Z)-octadecenoyl-sn-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA"}
{"X":30491,"RHEA_ID":28579,"compounds":"Co(2+)(in) => Co(2+)(out)"}
{"X":30492,"RHEA_ID":28580,"DIRECTION":"RL","MASTER_ID":28578,"ecocyc":"TRANS-RXN-141A","compounds":"Co(2+)(out) => Co(2+)(in)"}
{"X":30493,"RHEA_ID":28581,"compounds":"Co(2+)(in) <=> Co(2+)(out)"}
{"X":30494,"RHEA_ID":38444,"DIRECTION":"LR","MASTER_ID":38443,"metacyc":"RXNQT-4193","compounds":"a long chain fatty alcohol + an acyl-CoA => a wax ester + CoA"}
{"X":30495,"RHEA_ID":28583,"DIRECTION":"LR","MASTER_ID":28582,"ecocyc":"DUDPKIN-RXN","metacyc":"DUDPKIN-RXN","compounds":"ATP + dUDP => ADP + dUTP"}
{"X":30496,"RHEA_ID":28584,"compounds":"ADP + dUTP => ATP + dUDP"}
{"X":30497,"RHEA_ID":38447,"DIRECTION":"UN","MASTER_ID":38447,"ec":"3.2.1.187","compounds":"4-O-(beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + H2O = 4-O-(beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose"}
{"X":30498,"RHEA_ID":38448,"DIRECTION":"LR","MASTER_ID":38447,"metacyc":"RXN-14092","compounds":"4-O-(beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + H2O => 4-O-(beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose"}
{"X":30499,"RHEA_ID":28599,"compounds":"H2O + N-acetyl-L-lysine => acetate + L-lysine"}
{"X":30500,"RHEA_ID":28600,"compounds":"acetate + L-lysine => H2O + N-acetyl-L-lysine"}
{"X":30501,"RHEA_ID":38452,"compounds":"hydrogen sulfide + NADP(+) + n sulfur => NADPH + (n+1) sulfur"}
{"X":30502,"RHEA_ID":28603,"DIRECTION":"LR","MASTER_ID":28602,"metacyc":"1.14.13.117-RXN","compounds":"L-isoleucine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (1E,2S)-2-methylbutanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":30503,"RHEA_ID":28604,"compounds":"(1E,2S)-2-methylbutanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-isoleucine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}
{"X":30504,"RHEA_ID":38455,"compounds":"1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)"}
{"X":30505,"RHEA_ID":28606,"DIRECTION":"UN","MASTER_ID":28606,"ec":"1.14.14.38","compounds":"L-valine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-2-methylpropanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":30506,"RHEA_ID":28607,"DIRECTION":"LR","MASTER_ID":28606,"metacyc":"1.14.13.118-RXN","compounds":"L-valine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-2-methylpropanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":30507,"RHEA_ID":28608,"compounds":"(E)-2-methylpropanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-valine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}
{"X":30508,"RHEA_ID":38460,"DIRECTION":"LR","MASTER_ID":38459,"metacyc":"RXN-17177","compounds":"2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + a mycolipenoyl-CoA => 2-O-(long-chain fatty acyl)-3-O-mycolipenoyl-trehalose + CoA"}
{"X":30509,"RHEA_ID":28610,"DIRECTION":"UN","MASTER_ID":28610,"ec":"3.6.1.9","compounds":"H2O + XTP = diphosphate + H(+) + XMP"}
{"X":30510,"RHEA_ID":28611,"DIRECTION":"LR","MASTER_ID":28610,"ecocyc":"RXN0-1603","metacyc":"RXN0-1603","reactome":"R-HSA-2509831.4","compounds":"H2O + XTP => diphosphate + H(+) + XMP"}
{"X":30511,"RHEA_ID":28612,"compounds":"diphosphate + H(+) + XMP => H2O + XTP"}
{"X":30512,"RHEA_ID":38464,"compounds":"a 1-acyl-sn-glycerol + an acyl-CoA => a 1,2-diacyl-sn-glycerol + CoA"}
{"X":30513,"RHEA_ID":28614,"compounds":"(1Z,2S)-2-methylbutanal oxime = (2S)-2-methylbutanenitrile + H2O"}
{"X":30514,"RHEA_ID":28615,"compounds":"(1Z,2S)-2-methylbutanal oxime => (2S)-2-methylbutanenitrile + H2O"}
{"X":30515,"RHEA_ID":28616,"compounds":"(2S)-2-methylbutanenitrile + H2O => (1Z,2S)-2-methylbutanal oxime"}
{"X":30516,"RHEA_ID":38472,"DIRECTION":"LR","MASTER_ID":38471,"metacyc":"RXN-14431","compounds":"L-histidine + 3 S-adenosyl-L-methionine => 3 H(+) + hercynine + 3 S-adenosyl-L-homocysteine"}
{"X":30517,"RHEA_ID":28618,"compounds":"2-methylbutyronitrile + H(+) + NADPH + O2 = 2-hydroxy-2-methylbutanenitrile + H2O + NADP(+)"}
{"X":30518,"RHEA_ID":28619,"compounds":"2-methylbutyronitrile + H(+) + NADPH + O2 => 2-hydroxy-2-methylbutanenitrile + H2O + NADP(+)"}
{"X":30519,"RHEA_ID":28620,"compounds":"2-hydroxy-2-methylbutanenitrile + H2O + NADP(+) => 2-methylbutyronitrile + H(+) + NADPH + O2"}
{"X":30520,"RHEA_ID":38476,"DIRECTION":"LR","MASTER_ID":38475,"metacyc":"RXN-14438","compounds":"L-histidine + S-adenosyl-L-methionine => H(+) + N(alpha)-methyl-L-histidine + S-adenosyl-L-homocysteine"}
{"X":30521,"RHEA_ID":28622,"DIRECTION":"RL","MASTER_ID":27318,"reactome":"R-HSA-109529.1","compounds":"uracil(out) => uracil(in)"}
{"X":30522,"RHEA_ID":28623,"compounds":"(-)-vetispiradiene + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + solavetivol"}
{"X":30523,"RHEA_ID":28624,"DIRECTION":"LR","MASTER_ID":28623,"metacyc":"RXN-4842","compounds":"(-)-vetispiradiene + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + solavetivol"}
{"X":30524,"RHEA_ID":28625,"compounds":"H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + solavetivol => (-)-vetispiradiene + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":30525,"RHEA_ID":38481,"compounds":"H(+) + N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-homocysteine => N(alpha)-methyl-L-histidine + S-adenosyl-L-methionine"}
{"X":30526,"RHEA_ID":28627,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + solavetivol = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + solavetivone"}
{"X":30527,"RHEA_ID":28628,"DIRECTION":"LR","MASTER_ID":28627,"metacyc":"RXN-11907","compounds":"O2 + reduced [NADPH--hemoprotein reductase] + solavetivol => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + solavetivone"}
{"X":30528,"RHEA_ID":38484,"compounds":"a 2,3-diacyl-sn-glycerol + H2O => a 2-acylglycerol + a fatty acid + H(+)"}
{"X":30529,"RHEA_ID":38485,"compounds":"a 2-acylglycerol + a fatty acid + H(+) => a 2,3-diacyl-sn-glycerol + H2O"}
{"X":30530,"RHEA_ID":28631,"compounds":"dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate = 2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-galactose"}
{"X":30531,"RHEA_ID":28632,"compounds":"dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate => 2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-galactose"}
{"X":30532,"RHEA_ID":38488,"compounds":"1-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + glycerol + H(+)"}
{"X":30533,"RHEA_ID":28634,"DIRECTION":"BI","MASTER_ID":28631,"metacyc":"RFFTRANS-RXN","compounds":"dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate <=> 2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-galactose"}
{"X":30534,"RHEA_ID":28635,"DIRECTION":"UN","MASTER_ID":28635,"ec":"4.2.3.61","compounds":"(2E,6E)-farnesyl diphosphate = (+)-5-epi-aristolochene + diphosphate"}
{"X":30535,"RHEA_ID":28636,"compounds":"(2E,6E)-farnesyl diphosphate => (+)-5-epi-aristolochene + diphosphate"}
{"X":30536,"RHEA_ID":28637,"compounds":"(+)-5-epi-aristolochene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":30537,"RHEA_ID":28638,"compounds":"(2E,6E)-farnesyl diphosphate <=> (+)-5-epi-aristolochene + diphosphate"}
{"X":30538,"RHEA_ID":28639,"DIRECTION":"UN","MASTER_ID":28639,"ec":"4.2.3.62","compounds":"(2Z,6E)-farnesyl diphosphate = (-)-gamma-cadinene + diphosphate"}
{"X":30539,"RHEA_ID":28640,"DIRECTION":"LR","MASTER_ID":28639,"metacyc":"RXN-11906","compounds":"(2Z,6E)-farnesyl diphosphate => (-)-gamma-cadinene + diphosphate"}
{"X":30540,"RHEA_ID":28641,"compounds":"(-)-gamma-cadinene + diphosphate => (2Z,6E)-farnesyl diphosphate"}
{"X":30541,"RHEA_ID":38497,"compounds":"a 1,3-diacylglycerol + a fatty acid + H(+) => a triacylglycerol + H2O"}
{"X":30542,"RHEA_ID":28643,"DIRECTION":"UN","MASTER_ID":28643,"ec":"4.2.3.65","compounds":"(2E,6E)-farnesyl diphosphate = alpha-zingiberene + diphosphate"}
{"X":30543,"RHEA_ID":28644,"DIRECTION":"LR","MASTER_ID":28643,"metacyc":"RXN-8425","compounds":"(2E,6E)-farnesyl diphosphate => alpha-zingiberene + diphosphate"}
{"X":30544,"RHEA_ID":28645,"compounds":"alpha-zingiberene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":30545,"RHEA_ID":38501,"compounds":"a 2,3-diacyl-sn-glycerol + a fatty acid + H(+) => a triacyl-sn-glycerol + H2O"}
{"X":30546,"RHEA_ID":38502,"compounds":"a triacyl-sn-glycerol + H2O <=> a 2,3-diacyl-sn-glycerol + a fatty acid + H(+)"}
{"X":30547,"RHEA_ID":28648,"DIRECTION":"LR","MASTER_ID":28647,"metacyc":"RXN-1303","compounds":"acetophenone + 2 ATP + H2O + hydrogencarbonate => 3-oxo-3-phenylpropanoate + 2 ADP + 2 H(+) + 2 phosphate"}
{"X":30548,"RHEA_ID":28649,"compounds":"3-oxo-3-phenylpropanoate + 2 ADP + 2 H(+) + 2 phosphate => acetophenone + 2 ATP + H2O + hydrogencarbonate"}
{"X":30549,"RHEA_ID":38505,"compounds":"a 1-acyl-sn-glycerol + a fatty acid + H(+) => 1,3-diacyl-sn-glycerol + H2O"}
{"X":30550,"RHEA_ID":38506,"compounds":"1,3-diacyl-sn-glycerol + H2O <=> a 1-acyl-sn-glycerol + a fatty acid + H(+)"}
{"X":30551,"RHEA_ID":28652,"DIRECTION":"LR","MASTER_ID":28651,"metacyc":"NUCLEOSIDE-OXIDASE-RXN","compounds":"inosine + O2 => 9-riburonosylhypoxanthine + H(+) + H2O"}
{"X":30552,"RHEA_ID":28653,"compounds":"9-riburonosylhypoxanthine + H(+) + H2O => inosine + O2"}
{"X":30553,"RHEA_ID":38509,"compounds":"2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) + octadecanoate => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O"}
{"X":30554,"RHEA_ID":38510,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O <=> 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) + octadecanoate"}
{"X":30555,"RHEA_ID":28656,"DIRECTION":"LR","MASTER_ID":28655,"metacyc":"RXN-16574","compounds":"glutathione S,S-dioxide + H2O => glutathione + H(+) + sulfite"}
{"X":30556,"RHEA_ID":28657,"compounds":"glutathione + H(+) + sulfite => glutathione S,S-dioxide + H2O"}
{"X":30557,"RHEA_ID":38513,"compounds":"(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O"}
{"X":30558,"RHEA_ID":28659,"compounds":"beta-lactose + H2O = beta-D-galactose + beta-D-glucose"}
{"X":30559,"RHEA_ID":28660,"DIRECTION":"LR","MASTER_ID":28659,"ecocyc":"BETAGALACTOSID-RXN","metacyc":"BETAGALACTOSID-RXN","compounds":"beta-lactose + H2O => beta-D-galactose + beta-D-glucose"}
{"X":30560,"RHEA_ID":28661,"compounds":"beta-D-galactose + beta-D-glucose => beta-lactose + H2O"}
{"X":30561,"RHEA_ID":38517,"compounds":"(9Z)-octadecenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) => 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O"}
{"X":30562,"RHEA_ID":38518,"compounds":"1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O <=> (9Z)-octadecenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+)"}
{"X":30563,"RHEA_ID":28664,"compounds":"H2O + melibiose => alpha-D-galactose + beta-D-glucose"}
{"X":30564,"RHEA_ID":28665,"compounds":"alpha-D-galactose + beta-D-glucose => H2O + melibiose"}
{"X":30565,"RHEA_ID":38521,"compounds":"(9Z)-octadecenoate + 2-octadecanoylglycerol + H(+) => 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycerol + H2O"}
{"X":30566,"RHEA_ID":28667,"compounds":"H(+) + hydroxyacetone + NADH = (S)-propane-1,2-diol + NAD(+)"}
{"X":30567,"RHEA_ID":28668,"DIRECTION":"LR","MASTER_ID":28667,"ecocyc":"RXN-8632","metacyc":"RXN-8632","compounds":"H(+) + hydroxyacetone + NADH => (S)-propane-1,2-diol + NAD(+)"}
{"X":30568,"RHEA_ID":28669,"compounds":"(S)-propane-1,2-diol + NAD(+) => H(+) + hydroxyacetone + NADH"}
{"X":30569,"RHEA_ID":28670,"compounds":"H(+) + hydroxyacetone + NADH <=> (S)-propane-1,2-diol + NAD(+)"}
{"X":30570,"RHEA_ID":38526,"compounds":"1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O <=> (9Z)-octadecenoate + 2-(9Z,12Z-octadecadienoyl)-glycerol + H(+)"}
{"X":30571,"RHEA_ID":28672,"DIRECTION":"LR","MASTER_ID":28671,"ecocyc":"COBALADENOSYLTRANS-RXN","metacyc":"COBALADENOSYLTRANS-RXN","compounds":"2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] => 2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate"}
{"X":30572,"RHEA_ID":28673,"compounds":"2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate => 2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein]"}
{"X":30573,"RHEA_ID":38530,"compounds":"1-(9Z-octadecenoyl)-2-O-(5Z,8Z,11Z,14Z-eicosatetraenyl)-sn-glycerol + H2O <=> (9Z)-octadecenoate + 2-O-(5Z,8Z,11Z,14Z)-eicosatetraenylglycerol + H(+)"}
{"X":30574,"RHEA_ID":28676,"compounds":"alpha-D-galactose => beta-D-galactose"}
{"X":30575,"RHEA_ID":28677,"compounds":"beta-D-galactose => alpha-D-galactose"}
{"X":30576,"RHEA_ID":28678,"DIRECTION":"BI","MASTER_ID":28675,"metacyc":"ALDOSE1EPIM-RXN","compounds":"alpha-D-galactose <=> beta-D-galactose"}
{"X":30577,"RHEA_ID":48444,"compounds":"H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol = a fatty acid + H(+) + long chain 2-acyl-3-O-beta-D-galactosyl-sn-glycerol"}
{"X":30578,"RHEA_ID":28680,"DIRECTION":"LR","MASTER_ID":28679,"ecocyc":"DHHB-METHYLTRANSFER-RXN","metacyc":"DHHB-METHYLTRANSFER-RXN","compounds":"3-demethylubiquinol-8 + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + ubiquinol-8"}
{"X":30579,"RHEA_ID":28681,"compounds":"H(+) + S-adenosyl-L-homocysteine + ubiquinol-8 => 3-demethylubiquinol-8 + S-adenosyl-L-methionine"}
{"X":30580,"RHEA_ID":28682,"compounds":"3-demethylubiquinol-8 + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + ubiquinol-8"}
{"X":30581,"RHEA_ID":38554,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoate + O2 <=> (R)-2-hydroxyhexadecanoate + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":30582,"RHEA_ID":28684,"compounds":"L-aspartate + ubiquinone-8 => iminosuccinate + ubiquinol-8"}
{"X":30583,"RHEA_ID":28685,"compounds":"iminosuccinate + ubiquinol-8 => L-aspartate + ubiquinone-8"}
{"X":30584,"RHEA_ID":28686,"compounds":"L-aspartate + ubiquinone-8 <=> iminosuccinate + ubiquinol-8"}
{"X":30585,"RHEA_ID":38558,"compounds":"an all-trans-retinyl ester + H2O <=> a fatty acid + all-trans-retinol + H(+)"}
{"X":30586,"RHEA_ID":28688,"compounds":"(S)-dihydroorotate + ubiquinone-8 => orotate + ubiquinol-8"}
{"X":30587,"RHEA_ID":28689,"compounds":"orotate + ubiquinol-8 => (S)-dihydroorotate + ubiquinone-8"}
{"X":30588,"RHEA_ID":28690,"compounds":"(S)-dihydroorotate + ubiquinone-8 <=> orotate + ubiquinol-8"}
{"X":30589,"RHEA_ID":38562,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + tetracosanoate <=> (R)-2-hydroxytetracosanoate + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":30590,"RHEA_ID":28692,"DIRECTION":"LR","MASTER_ID":28691,"ecocyc":"RXN0-6491","metacyc":"RXN0-6491","compounds":"(S)-dihydroorotate + a ubiquinone => a ubiquinol + orotate"}
{"X":30591,"RHEA_ID":28693,"compounds":"a ubiquinol + orotate => (S)-dihydroorotate + a ubiquinone"}
{"X":30592,"RHEA_ID":28694,"compounds":"(S)-dihydroorotate + a ubiquinone <=> a ubiquinol + orotate"}
{"X":30593,"RHEA_ID":28695,"compounds":"hydrogencarbonate(in) = hydrogencarbonate(out)"}
{"X":30594,"RHEA_ID":28696,"compounds":"hydrogencarbonate(in) => hydrogencarbonate(out)"}
{"X":30595,"RHEA_ID":28697,"DIRECTION":"RL","MASTER_ID":28695,"ecocyc":"TRANS-RXN-151","reactome":"R-HSA-2752067.1","compounds":"hydrogencarbonate(out) => hydrogencarbonate(in)"}
{"X":30596,"RHEA_ID":28698,"compounds":"hydrogencarbonate(in) <=> hydrogencarbonate(out)"}
{"X":30597,"RHEA_ID":28699,"compounds":"Mn(2+)(in) = Mn(2+)(out)"}
{"X":30598,"RHEA_ID":28700,"compounds":"Mn(2+)(in) => Mn(2+)(out)"}
{"X":30599,"RHEA_ID":28701,"DIRECTION":"RL","MASTER_ID":28699,"ecocyc":"RXN0-16","reactome":"R-HSA-8959798.1","compounds":"Mn(2+)(out) => Mn(2+)(in)"}
{"X":30600,"RHEA_ID":28702,"compounds":"Mn(2+)(in) <=> Mn(2+)(out)"}
{"X":30601,"RHEA_ID":38574,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine(in) <=> a 1,2-diacyl-sn-glycero-3-phosphocholine(out)"}
{"X":30602,"RHEA_ID":28704,"DIRECTION":"LR","MASTER_ID":28703,"reactome":"R-HSA-437300.2","compounds":"Cu(2+)(in) => Cu(2+)(out)"}
{"X":30603,"RHEA_ID":28705,"DIRECTION":"RL","MASTER_ID":28703,"ecocyc":"RXN0-14","compounds":"Cu(2+)(out) => Cu(2+)(in)"}
{"X":30604,"RHEA_ID":28706,"compounds":"Cu(2+)(in) <=> Cu(2+)(out)"}
{"X":30605,"RHEA_ID":38578,"compounds":"1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H(+)"}
{"X":30606,"RHEA_ID":28708,"compounds":"Cd(2+)(in) => Cd(2+)(out)"}
{"X":30607,"RHEA_ID":28709,"DIRECTION":"RL","MASTER_ID":28707,"ecocyc":"RXN0-10","compounds":"Cd(2+)(out) => Cd(2+)(in)"}
{"X":30608,"RHEA_ID":28710,"compounds":"Cd(2+)(in) <=> Cd(2+)(out)"}
{"X":30609,"RHEA_ID":48476,"compounds":"ganglioside GT1a (d18:1(4E)) + H2O = ganglioside GD1a (18:1(4E)) + N-acetylneuraminate"}
{"X":30610,"RHEA_ID":28712,"compounds":"H(+)(in) + N-(4-aminobenzoyl)-L-glutamate(in) => H(+)(out) + N-(4-aminobenzoyl)-L-glutamate(out)"}
{"X":30611,"RHEA_ID":28713,"DIRECTION":"RL","MASTER_ID":28711,"ecocyc":"TRANS-RXN0-452","compounds":"H(+)(out) + N-(4-aminobenzoyl)-L-glutamate(out) => H(+)(in) + N-(4-aminobenzoyl)-L-glutamate(in)"}
{"X":30612,"RHEA_ID":28714,"compounds":"H(+)(in) + N-(4-aminobenzoyl)-L-glutamate(in) <=> H(+)(out) + N-(4-aminobenzoyl)-L-glutamate(out)"}
{"X":30613,"RHEA_ID":38586,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + H(+) + phosphate"}
{"X":30614,"RHEA_ID":28716,"compounds":"(R)-malate(in) + 2 H(+)(in) => (R)-malate(out) + 2 H(+)(out)"}
{"X":30615,"RHEA_ID":28717,"DIRECTION":"RL","MASTER_ID":28715,"ecocyc":"TRANS-RXN0-451","compounds":"(R)-malate(out) + 2 H(+)(out) => (R)-malate(in) + 2 H(+)(in)"}
{"X":30616,"RHEA_ID":28718,"compounds":"(R)-malate(in) + 2 H(+)(in) <=> (R)-malate(out) + 2 H(+)(out)"}
{"X":30617,"RHEA_ID":28719,"compounds":"adenine(in) + H(+)(in) = adenine(out) + H(+)(out)"}
{"X":30618,"RHEA_ID":28720,"compounds":"adenine(in) + H(+)(in) => adenine(out) + H(+)(out)"}
{"X":30619,"RHEA_ID":28721,"DIRECTION":"RL","MASTER_ID":28719,"ecocyc":"TRANS-RXN0-447","compounds":"adenine(out) + H(+)(out) => adenine(in) + H(+)(in)"}
{"X":30620,"RHEA_ID":28722,"compounds":"adenine(in) + H(+)(in) <=> adenine(out) + H(+)(out)"}
{"X":30621,"RHEA_ID":48488,"DIRECTION":"UN","MASTER_ID":48488,"ec":"1.1.1.105","compounds":"all-trans-retinol--[retinol-binding protein] + NAD(+) = all-trans-retinal--[retinol-binding protein] + H(+) + NADH"}
{"X":30622,"RHEA_ID":28724,"compounds":"(S)-allantoin(in) + H(+)(in) => (S)-allantoin(out) + H(+)(out)"}
{"X":30623,"RHEA_ID":28725,"DIRECTION":"RL","MASTER_ID":28723,"ecocyc":"TRANS-RXN0-444","compounds":"(S)-allantoin(out) + H(+)(out) => (S)-allantoin(in) + H(+)(in)"}
{"X":30624,"RHEA_ID":28726,"compounds":"(S)-allantoin(in) + H(+)(in) <=> (S)-allantoin(out) + H(+)(out)"}
{"X":30625,"RHEA_ID":28727,"compounds":"Cu(2+)(in) + H(+)(in) = Cu(2+)(out) + H(+)(out)"}
{"X":30626,"RHEA_ID":38599,"DIRECTION":"UN","MASTER_ID":38599,"ec":"2.4.99.20","compounds":"NADP(+) + nicotinate = nicotinamide + nicotinate-adenine dinucleotide phosphate"}
{"X":30627,"RHEA_ID":28729,"compounds":"Cu(2+)(out) + H(+)(out) => Cu(2+)(in) + H(+)(in)"}
{"X":30628,"RHEA_ID":28730,"compounds":"Cu(2+)(in) + H(+)(in) <=> Cu(2+)(out) + H(+)(out)"}
{"X":30629,"RHEA_ID":28731,"compounds":"H(+)(out) + L-leucine(in) = H(+)(in) + L-leucine(out)"}
{"X":30630,"RHEA_ID":38603,"compounds":"NADP(+) = 2'-phospho-cyclic ADP-ribose + nicotinamide"}
{"X":30631,"RHEA_ID":28733,"compounds":"H(+)(in) + L-leucine(out) => H(+)(out) + L-leucine(in)"}
{"X":30632,"RHEA_ID":28734,"compounds":"H(+)(out) + L-leucine(in) <=> H(+)(in) + L-leucine(out)"}
{"X":30633,"RHEA_ID":28735,"compounds":"H(+)(in) + spermidine(out) = H(+)(out) + spermidine(in)"}
{"X":30634,"RHEA_ID":38607,"compounds":"2'-phospho-cyclic ADP-ribose + nicotinate = nicotinate-adenine dinucleotide phosphate"}
{"X":30635,"RHEA_ID":28737,"compounds":"H(+)(out) + spermidine(in) => H(+)(in) + spermidine(out)"}
{"X":30636,"RHEA_ID":28738,"compounds":"H(+)(in) + spermidine(out) <=> H(+)(out) + spermidine(in)"}
{"X":30637,"RHEA_ID":28739,"compounds":"Cd(2+)(in) + H(+)(out) = Cd(2+)(out) + H(+)(in)"}
{"X":30638,"RHEA_ID":38611,"compounds":"NAD(+) = cyclic ADP-ribose + H(+) + nicotinamide"}
{"X":30639,"RHEA_ID":28741,"compounds":"Cd(2+)(out) + H(+)(in) => Cd(2+)(in) + H(+)(out)"}
{"X":30640,"RHEA_ID":28742,"compounds":"Cd(2+)(in) + H(+)(out) <=> Cd(2+)(out) + H(+)(in)"}
{"X":30641,"RHEA_ID":28743,"compounds":"nitrate(in) + nitrite(out) = nitrate(out) + nitrite(in)"}
{"X":30642,"RHEA_ID":28744,"compounds":"nitrate(in) + nitrite(out) => nitrate(out) + nitrite(in)"}
{"X":30643,"RHEA_ID":28745,"DIRECTION":"RL","MASTER_ID":28743,"ecocyc":"TRANS-RXN0-239","compounds":"nitrate(out) + nitrite(in) => nitrate(in) + nitrite(out)"}
{"X":30644,"RHEA_ID":28746,"compounds":"nitrate(in) + nitrite(out) <=> nitrate(out) + nitrite(in)"}
{"X":30645,"RHEA_ID":28747,"compounds":"NH4(+)(in) = NH4(+)(out)"}
{"X":30646,"RHEA_ID":38619,"DIRECTION":"UN","MASTER_ID":38619,"ec":"2.4.2.55","compounds":"nicotinate beta-D-ribonucleotide + phenol = H(+) + nicotinate + phenyl 5-phospho-alpha-D-ribofuranoside"}
{"X":30647,"RHEA_ID":28749,"DIRECTION":"RL","MASTER_ID":28747,"ecocyc":"TRANS-RXN0-206","metacyc":"RXN-9615","reactome":"R-HSA-444416.1","compounds":"NH4(+)(out) => NH4(+)(in)"}
{"X":30648,"RHEA_ID":28750,"compounds":"NH4(+)(in) <=> NH4(+)(out)"}
{"X":30649,"RHEA_ID":28751,"DIRECTION":"UN","MASTER_ID":28751,"ec":"1.1.5.3","compounds":"sn-glycerol 3-phosphate + ubiquinone-8 = dihydroxyacetone phosphate + ubiquinol-8"}
{"X":30650,"RHEA_ID":38623,"compounds":"1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-octanoyl-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":30651,"RHEA_ID":28753,"compounds":"dihydroxyacetone phosphate + ubiquinol-8 => sn-glycerol 3-phosphate + ubiquinone-8"}
{"X":30652,"RHEA_ID":28754,"DIRECTION":"BI","MASTER_ID":28751,"ecocyc":"GLYC3PDEHYDROG-RXN","metacyc":"GLYC3PDEHYDROG-RXN","compounds":"sn-glycerol 3-phosphate + ubiquinone-8 <=> dihydroxyacetone phosphate + ubiquinol-8"}
{"X":30653,"RHEA_ID":28755,"DIRECTION":"UN","MASTER_ID":28755,"ec":"1.1.5.3","compounds":"a ubiquinone + sn-glycerol 3-phosphate = a ubiquinol + dihydroxyacetone phosphate"}
{"X":30654,"RHEA_ID":38627,"compounds":"1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA = 1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":30655,"RHEA_ID":28757,"compounds":"a ubiquinol + dihydroxyacetone phosphate => a ubiquinone + sn-glycerol 3-phosphate"}
{"X":30656,"RHEA_ID":38629,"compounds":"1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA => 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA"}
{"X":30657,"RHEA_ID":28759,"DIRECTION":"UN","MASTER_ID":28759,"ec":"2.4.1.325","compounds":"beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-1-diphospho-di-trans,octa-cis-undecaprenol + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose = alpha-D-FucNAc4-(1->4)-beta-D-ManNAcA-(1->4)-D-GlcNAc-undecaprenyl diphosphate + dTDP + H(+)"}
{"X":30658,"RHEA_ID":28760,"DIRECTION":"LR","MASTER_ID":28759,"ecocyc":"FUC4NACTRANS-RXN","metacyc":"FUC4NACTRANS-RXN","compounds":"beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-1-diphospho-di-trans,octa-cis-undecaprenol + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose => alpha-D-FucNAc4-(1->4)-beta-D-ManNAcA-(1->4)-D-GlcNAc-undecaprenyl diphosphate + dTDP + H(+)"}
{"X":30659,"RHEA_ID":28761,"compounds":"alpha-D-FucNAc4-(1->4)-beta-D-ManNAcA-(1->4)-D-GlcNAc-undecaprenyl diphosphate + dTDP + H(+) => beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-1-diphospho-di-trans,octa-cis-undecaprenol + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose"}
{"X":30660,"RHEA_ID":38633,"compounds":"1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA"}
{"X":30661,"RHEA_ID":28763,"compounds":"acetyl-CoA + dTDP-4-amino-4,6-dideoxy-D-galactose = CoA + dTDP-4-acetamido-4,6-dideoxy-D-galactose + H(+)"}
{"X":30662,"RHEA_ID":38635,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":30663,"RHEA_ID":28765,"compounds":"CoA + dTDP-4-acetamido-4,6-dideoxy-D-galactose + H(+) => acetyl-CoA + dTDP-4-amino-4,6-dideoxy-D-galactose"}
{"X":30664,"RHEA_ID":28766,"compounds":"acetyl-CoA + dTDP-4-amino-4,6-dideoxy-D-galactose <=> CoA + dTDP-4-acetamido-4,6-dideoxy-D-galactose + H(+)"}
{"X":30665,"RHEA_ID":28767,"DIRECTION":"UN","MASTER_ID":28767,"ec":"1.13.12.16","compounds":"ethylnitronate + O2 = acetaldehyde + chemical entity + H(+) + nitrite"}
{"X":30666,"RHEA_ID":38639,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":30667,"RHEA_ID":28769,"compounds":"acetaldehyde + chemical entity + H(+) + nitrite => ethylnitronate + O2"}
{"X":30668,"RHEA_ID":28770,"compounds":"ethylnitronate + O2 <=> acetaldehyde + chemical entity + H(+) + nitrite"}
{"X":30669,"RHEA_ID":28771,"compounds":"(2E)-hexadecenoyl-CoA = (9Z)-hexadecenoyl-CoA"}
{"X":30670,"RHEA_ID":28772,"compounds":"(2E)-hexadecenoyl-CoA => (9Z)-hexadecenoyl-CoA"}
{"X":30671,"RHEA_ID":28773,"compounds":"(9Z)-hexadecenoyl-CoA => (2E)-hexadecenoyl-CoA"}
{"X":30672,"RHEA_ID":28774,"compounds":"(2E)-hexadecenoyl-CoA <=> (9Z)-hexadecenoyl-CoA"}
{"X":30673,"RHEA_ID":28775,"DIRECTION":"UN","MASTER_ID":28775,"ec":"1.13.12.18","compounds":"dinoflagellate luciferin + O2 = H(+) + H2O + hnu + oxidized dinoflagellate luciferin"}
{"X":30674,"RHEA_ID":28776,"DIRECTION":"LR","MASTER_ID":28775,"metacyc":"RXN-12115","compounds":"dinoflagellate luciferin + O2 => H(+) + H2O + hnu + oxidized dinoflagellate luciferin"}
{"X":30675,"RHEA_ID":28777,"compounds":"H(+) + H2O + hnu + oxidized dinoflagellate luciferin => dinoflagellate luciferin + O2"}
{"X":30676,"RHEA_ID":38649,"compounds":"(9Z)-octadecenoate + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+) => 1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O"}
{"X":30677,"RHEA_ID":28779,"compounds":"4-hydroxy-L-threonine = glycine + glycolaldehyde"}
{"X":30678,"RHEA_ID":28780,"compounds":"4-hydroxy-L-threonine => glycine + glycolaldehyde"}
{"X":30679,"RHEA_ID":28781,"compounds":"glycine + glycolaldehyde => 4-hydroxy-L-threonine"}
{"X":30680,"RHEA_ID":28782,"DIRECTION":"BI","MASTER_ID":28779,"ecocyc":"RXN0-6563","metacyc":"RXN0-6563","compounds":"4-hydroxy-L-threonine <=> glycine + glycolaldehyde"}
{"X":30681,"RHEA_ID":28783,"compounds":"H2O + L-cysteinylglycine = glycine + L-cysteine"}
{"X":30682,"RHEA_ID":28784,"DIRECTION":"LR","MASTER_ID":28783,"ecocyc":"RXN-6622","metacyc":"RXN-6622","reactome":"R-HSA-1247910.2","compounds":"H2O + L-cysteinylglycine => glycine + L-cysteine"}
{"X":30683,"RHEA_ID":28785,"compounds":"glycine + L-cysteine => H2O + L-cysteinylglycine"}
{"X":30684,"RHEA_ID":38657,"compounds":"D-glucose + tulipalin B => 6-tuliposide B"}
{"X":30685,"RHEA_ID":28787,"compounds":"4-hydroxy-L-threonine + ATP = 4-(phosphooxy)-L-threonine + ADP + H(+)"}
{"X":30686,"RHEA_ID":28788,"compounds":"4-hydroxy-L-threonine + ATP => 4-(phosphooxy)-L-threonine + ADP + H(+)"}
{"X":30687,"RHEA_ID":38660,"compounds":"1,2-di-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)"}
{"X":30688,"RHEA_ID":28790,"DIRECTION":"BI","MASTER_ID":28787,"ecocyc":"RXN0-6564","metacyc":"RXN0-6564","compounds":"4-hydroxy-L-threonine + ATP <=> 4-(phosphooxy)-L-threonine + ADP + H(+)"}
{"X":30689,"RHEA_ID":28791,"DIRECTION":"UN","MASTER_ID":28791,"ec":"1.3.1.1","compounds":"5,6-dihydrothymine + NAD(+) = H(+) + NADH + thymine"}
{"X":30690,"RHEA_ID":28792,"compounds":"5,6-dihydrothymine + NAD(+) => H(+) + NADH + thymine"}
{"X":30691,"RHEA_ID":38664,"compounds":"1,2-diacyl-sn-glycero-3-phospho-L-serine(in) => 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)"}
{"X":30692,"RHEA_ID":38665,"compounds":"1,2-diacyl-sn-glycero-3-phospho-L-serine(out) => 1,2-diacyl-sn-glycero-3-phospho-L-serine(in)"}
{"X":30693,"RHEA_ID":28795,"DIRECTION":"UN","MASTER_ID":28795,"ec":"1.16.1.10","compounds":"2 a Fe(II)-siderophore + H(+) + NADP(+) = 2 a Fe(III)-siderophore + NADPH"}
{"X":30694,"RHEA_ID":28795,"DIRECTION":"UN","MASTER_ID":28795,"ec":"1.16.1.9","compounds":"2 a Fe(II)-siderophore + H(+) + NADP(+) = 2 a Fe(III)-siderophore + NADPH"}
{"X":30695,"RHEA_ID":38668,"compounds":"sphing-4-enine 1-phosphate(in) => sphing-4-enine 1-phosphate(out)"}
{"X":30696,"RHEA_ID":28797,"DIRECTION":"RL","MASTER_ID":28795,"ecocyc":"RXN0-6555","metacyc":"RXN0-6555","compounds":"2 a Fe(III)-siderophore + NADPH => 2 a Fe(II)-siderophore + H(+) + NADP(+)"}
{"X":30697,"RHEA_ID":28799,"compounds":"H2O + L-prolinylglycine = glycine + L-proline"}
{"X":30698,"RHEA_ID":38672,"compounds":"sphinganine 1-phosphate(in) => sphinganine 1-phosphate(out)"}
{"X":30699,"RHEA_ID":28801,"compounds":"glycine + L-proline => H2O + L-prolinylglycine"}
{"X":30700,"RHEA_ID":28802,"compounds":"H2O + L-prolinylglycine <=> glycine + L-proline"}
{"X":30701,"RHEA_ID":28803,"compounds":"H2O + L-ascorbate 6-phosphate = 3-dehydro-L-gulonate 6-phosphate"}
{"X":30702,"RHEA_ID":38676,"DIRECTION":"LR","MASTER_ID":38675,"metacyc":"ARACHIDONATE-8-LIPOXYGENASE-RXN","compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate"}
{"X":30703,"RHEA_ID":28805,"compounds":"3-dehydro-L-gulonate 6-phosphate => H2O + L-ascorbate 6-phosphate"}
{"X":30704,"RHEA_ID":48572,"compounds":"3,5-dichlorocatechol + O2 = (2E,4E)-2,4-dichloromuconate + 2 H(+)"}
{"X":30705,"RHEA_ID":28807,"DIRECTION":"UN","MASTER_ID":28807,"ec":"3.4.19.13","compounds":"glutathione + H2O = L-cysteinylglycine + L-glutamate"}
{"X":30706,"RHEA_ID":38680,"compounds":"ATP + H2O + sphinganine(in) => ADP + H(+) + phosphate + sphinganine(out)"}
{"X":30707,"RHEA_ID":28809,"compounds":"L-cysteinylglycine + L-glutamate => glutathione + H2O"}
{"X":30708,"RHEA_ID":38682,"compounds":"ATP + H2O + sphinganine(in) <=> ADP + H(+) + phosphate + sphinganine(out)"}
{"X":30709,"RHEA_ID":28811,"compounds":"2,3-dioxo-L-gulonate(in) + Na(+)(in) = 2,3-dioxo-L-gulonate(out) + Na(+)(out)"}
{"X":30710,"RHEA_ID":38684,"compounds":"ATP + H2O + sphing-4-enine(in) => ADP + H(+) + phosphate + sphing-4-enine(out)"}
{"X":30711,"RHEA_ID":28813,"DIRECTION":"RL","MASTER_ID":28811,"ecocyc":"TRANS-RXN0-235","compounds":"2,3-dioxo-L-gulonate(out) + Na(+)(out) => 2,3-dioxo-L-gulonate(in) + Na(+)(in)"}
{"X":30712,"RHEA_ID":28814,"compounds":"2,3-dioxo-L-gulonate(in) + Na(+)(in) <=> 2,3-dioxo-L-gulonate(out) + Na(+)(out)"}
{"X":30713,"RHEA_ID":28815,"compounds":"4-hydroxybenzoate(in) + H(+)(out) = 4-hydroxybenzoate(out) + H(+)(in)"}
{"X":30714,"RHEA_ID":38688,"compounds":"4-hydroxysphinganine(in) + ATP + H2O => 4-hydroxysphinganine(out) + ADP + H(+) + phosphate"}
{"X":30715,"RHEA_ID":28817,"compounds":"4-hydroxybenzoate(out) + H(+)(in) => 4-hydroxybenzoate(in) + H(+)(out)"}
{"X":30716,"RHEA_ID":28818,"compounds":"4-hydroxybenzoate(in) + H(+)(out) <=> 4-hydroxybenzoate(out) + H(+)(in)"}
{"X":30717,"RHEA_ID":28819,"compounds":"5-dehydro-D-gluconate(in) + H(+)(in) = 5-dehydro-D-gluconate(out) + H(+)(out)"}
{"X":30718,"RHEA_ID":38692,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)"}
{"X":30719,"RHEA_ID":28821,"DIRECTION":"RL","MASTER_ID":28819,"ecocyc":"TRANS-RXN0-228","compounds":"5-dehydro-D-gluconate(out) + H(+)(out) => 5-dehydro-D-gluconate(in) + H(+)(in)"}
{"X":30720,"RHEA_ID":28822,"compounds":"5-dehydro-D-gluconate(in) + H(+)(in) <=> 5-dehydro-D-gluconate(out) + H(+)(out)"}
{"X":30721,"RHEA_ID":28823,"compounds":"H(+)(in) + L-galactonate(in) = H(+)(out) + L-galactonate(out)"}
{"X":30722,"RHEA_ID":28824,"compounds":"H(+)(in) + L-galactonate(in) => H(+)(out) + L-galactonate(out)"}
{"X":30723,"RHEA_ID":28825,"DIRECTION":"RL","MASTER_ID":28823,"ecocyc":"TRANS-RXN0-227","compounds":"H(+)(out) + L-galactonate(out) => H(+)(in) + L-galactonate(in)"}
{"X":30724,"RHEA_ID":28826,"compounds":"H(+)(in) + L-galactonate(in) <=> H(+)(out) + L-galactonate(out)"}
{"X":30725,"RHEA_ID":28827,"compounds":"L-ornithine(out) + putrescine(in) = L-ornithine(in) + putrescine(out)"}
{"X":30726,"RHEA_ID":38700,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)"}
{"X":30727,"RHEA_ID":28829,"compounds":"L-ornithine(in) + putrescine(out) => L-ornithine(out) + putrescine(in)"}
{"X":30728,"RHEA_ID":28830,"compounds":"L-ornithine(out) + putrescine(in) <=> L-ornithine(in) + putrescine(out)"}
{"X":30729,"RHEA_ID":28831,"compounds":"D-gluconate(in) + H(+)(in) = D-gluconate(out) + H(+)(out)"}
{"X":30730,"RHEA_ID":28832,"compounds":"D-gluconate(in) + H(+)(in) => D-gluconate(out) + H(+)(out)"}
{"X":30731,"RHEA_ID":28833,"DIRECTION":"RL","MASTER_ID":28831,"ecocyc":"TRANS-RXN0-209","compounds":"D-gluconate(out) + H(+)(out) => D-gluconate(in) + H(+)(in)"}
{"X":30732,"RHEA_ID":28834,"compounds":"D-gluconate(in) + H(+)(in) <=> D-gluconate(out) + H(+)(out)"}
{"X":30733,"RHEA_ID":28835,"compounds":"citrate(out) + succinate(in) = citrate(in) + succinate(out)"}
{"X":30734,"RHEA_ID":38708,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-sn-glycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol"}
{"X":30735,"RHEA_ID":28837,"compounds":"citrate(in) + succinate(out) => citrate(out) + succinate(in)"}
{"X":30736,"RHEA_ID":28838,"compounds":"citrate(out) + succinate(in) <=> citrate(in) + succinate(out)"}
{"X":30737,"RHEA_ID":28839,"compounds":"H(+)(out) + Zn(2+)(in) = H(+)(in) + Zn(2+)(out)"}
{"X":30738,"RHEA_ID":38712,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecylglycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-3-(9Z)-octadecenoylglycerol"}
{"X":30739,"RHEA_ID":28841,"compounds":"H(+)(in) + Zn(2+)(out) => H(+)(out) + Zn(2+)(in)"}
{"X":30740,"RHEA_ID":28842,"compounds":"H(+)(out) + Zn(2+)(in) <=> H(+)(in) + Zn(2+)(out)"}
{"X":30741,"RHEA_ID":28843,"compounds":"choline(in) + H(+)(in) = choline(out) + H(+)(out)"}
{"X":30742,"RHEA_ID":38716,"compounds":"ATP + choline(out) + H2O => ADP + choline(in) + H(+) + phosphate"}
{"X":30743,"RHEA_ID":28845,"DIRECTION":"RL","MASTER_ID":28843,"ecocyc":"TRANS-RXN-99","compounds":"choline(out) + H(+)(out) => choline(in) + H(+)(in)"}
{"X":30744,"RHEA_ID":28846,"compounds":"choline(in) + H(+)(in) <=> choline(out) + H(+)(out)"}
{"X":30745,"RHEA_ID":28847,"compounds":"Li(+)(in) + melibiose(in) = Li(+)(out) + melibiose(out)"}
{"X":30746,"RHEA_ID":28848,"compounds":"Li(+)(in) + melibiose(in) => Li(+)(out) + melibiose(out)"}
{"X":30747,"RHEA_ID":28849,"DIRECTION":"RL","MASTER_ID":28847,"ecocyc":"TRANS-RXN-94B","compounds":"Li(+)(out) + melibiose(out) => Li(+)(in) + melibiose(in)"}
{"X":30748,"RHEA_ID":28850,"compounds":"Li(+)(in) + melibiose(in) <=> Li(+)(out) + melibiose(out)"}
{"X":30749,"RHEA_ID":28851,"compounds":"melibiose(in) + Na(+)(in) = melibiose(out) + Na(+)(out)"}
{"X":30750,"RHEA_ID":38724,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-sn-glycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-3-(9Z)-octadecenoyl-sn-glycerol"}
{"X":30751,"RHEA_ID":28853,"DIRECTION":"RL","MASTER_ID":28851,"ecocyc":"TRANS-RXN-94A","compounds":"melibiose(out) + Na(+)(out) => melibiose(in) + Na(+)(in)"}
{"X":30752,"RHEA_ID":28854,"compounds":"melibiose(in) + Na(+)(in) <=> melibiose(out) + Na(+)(out)"}
{"X":30753,"RHEA_ID":28855,"compounds":"H(+)(in) + melibiose(in) = H(+)(out) + melibiose(out)"}
{"X":30754,"RHEA_ID":38728,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol"}
{"X":30755,"RHEA_ID":28857,"DIRECTION":"RL","MASTER_ID":28855,"ecocyc":"TRANS-RXN-94","compounds":"H(+)(out) + melibiose(out) => H(+)(in) + melibiose(in)"}
{"X":30756,"RHEA_ID":28858,"compounds":"H(+)(in) + melibiose(in) <=> H(+)(out) + melibiose(out)"}
{"X":30757,"RHEA_ID":28859,"compounds":"Ag(+)(in) + H(+)(in) = Ag(+)(out) + H(+)(out)"}
{"X":30758,"RHEA_ID":38732,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-hexadecanoyl-sn-glycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol"}
{"X":30759,"RHEA_ID":28861,"compounds":"Ag(+)(out) + H(+)(out) => Ag(+)(in) + H(+)(in)"}
{"X":30760,"RHEA_ID":28862,"compounds":"Ag(+)(in) + H(+)(in) <=> Ag(+)(out) + H(+)(out)"}
{"X":30761,"RHEA_ID":28863,"compounds":"H(+)(out) + lactose(in) = H(+)(in) + lactose(out)"}
{"X":30762,"RHEA_ID":38736,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-hexadecanoylglycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-2-hexadecanoylglycerol"}
{"X":30763,"RHEA_ID":28865,"compounds":"H(+)(in) + lactose(out) => H(+)(out) + lactose(in)"}
{"X":30764,"RHEA_ID":28866,"compounds":"H(+)(out) + lactose(in) <=> H(+)(in) + lactose(out)"}
{"X":30765,"RHEA_ID":28867,"compounds":"H(+)(in) + lactose(in) = H(+)(out) + lactose(out)"}
{"X":30766,"RHEA_ID":38740,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol"}
{"X":30767,"RHEA_ID":28869,"DIRECTION":"RL","MASTER_ID":28867,"ecocyc":"TRANS-RXN-24","compounds":"H(+)(out) + lactose(out) => H(+)(in) + lactose(in)"}
{"X":30768,"RHEA_ID":28870,"compounds":"H(+)(in) + lactose(in) <=> H(+)(out) + lactose(out)"}
{"X":30769,"RHEA_ID":28871,"compounds":"D-fructuronate(in) + H(+)(in) = D-fructuronate(out) + H(+)(out)"}
{"X":30770,"RHEA_ID":38744,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-(9Z-octadecenoyl)-sn-glycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol"}
{"X":30771,"RHEA_ID":28873,"DIRECTION":"RL","MASTER_ID":28871,"ecocyc":"TRANS-RXN-81","compounds":"D-fructuronate(out) + H(+)(out) => D-fructuronate(in) + H(+)(in)"}
{"X":30772,"RHEA_ID":28874,"compounds":"D-fructuronate(in) + H(+)(in) <=> D-fructuronate(out) + H(+)(out)"}
{"X":30773,"RHEA_ID":28875,"compounds":"H(+)(in) + L-tyrosine(in) = H(+)(out) + L-tyrosine(out)"}
{"X":30774,"RHEA_ID":28876,"compounds":"H(+)(in) + L-tyrosine(in) => H(+)(out) + L-tyrosine(out)"}
{"X":30775,"RHEA_ID":28877,"DIRECTION":"RL","MASTER_ID":28875,"ecocyc":"TRANS-RXN-77","compounds":"H(+)(out) + L-tyrosine(out) => H(+)(in) + L-tyrosine(in)"}
{"X":30776,"RHEA_ID":28878,"compounds":"H(+)(in) + L-tyrosine(in) <=> H(+)(out) + L-tyrosine(out)"}
{"X":30777,"RHEA_ID":28879,"compounds":"H(+)(in) + L-tryptophan(in) = H(+)(out) + L-tryptophan(out)"}
{"X":30778,"RHEA_ID":28880,"compounds":"H(+)(in) + L-tryptophan(in) => H(+)(out) + L-tryptophan(out)"}
{"X":30779,"RHEA_ID":28881,"DIRECTION":"RL","MASTER_ID":28879,"ecocyc":"TRANS-RXN-76","compounds":"H(+)(out) + L-tryptophan(out) => H(+)(in) + L-tryptophan(in)"}
{"X":30780,"RHEA_ID":28882,"compounds":"H(+)(in) + L-tryptophan(in) <=> H(+)(out) + L-tryptophan(out)"}
{"X":30781,"RHEA_ID":28883,"compounds":"H(+)(in) + L-threonine(in) = H(+)(out) + L-threonine(out)"}
{"X":30782,"RHEA_ID":28884,"compounds":"H(+)(in) + L-threonine(in) => H(+)(out) + L-threonine(out)"}
{"X":30783,"RHEA_ID":28885,"compounds":"H(+)(out) + L-threonine(out) => H(+)(in) + L-threonine(in)"}
{"X":30784,"RHEA_ID":28886,"compounds":"H(+)(in) + L-threonine(in) <=> H(+)(out) + L-threonine(out)"}
{"X":30785,"RHEA_ID":28887,"compounds":"H(+)(in) + L-serine(in) = H(+)(out) + L-serine(out)"}
{"X":30786,"RHEA_ID":38760,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}
{"X":30787,"RHEA_ID":28889,"DIRECTION":"RL","MASTER_ID":28887,"ecocyc":"TRANS-RXN-71","compounds":"H(+)(out) + L-serine(out) => H(+)(in) + L-serine(in)"}
{"X":30788,"RHEA_ID":28890,"compounds":"H(+)(in) + L-serine(in) <=> H(+)(out) + L-serine(out)"}
{"X":30789,"RHEA_ID":28891,"compounds":"H(+)(in) + putrescine(in) = H(+)(out) + putrescine(out)"}
{"X":30790,"RHEA_ID":28892,"compounds":"H(+)(in) + putrescine(in) => H(+)(out) + putrescine(out)"}
{"X":30791,"RHEA_ID":38765,"compounds":"1-hexadecanoyl-N-(acetyl)-sphing-4-enine + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}
{"X":30792,"RHEA_ID":28894,"compounds":"H(+)(in) + putrescine(in) <=> H(+)(out) + putrescine(out)"}
{"X":30793,"RHEA_ID":28895,"compounds":"cadaverine(in) + L-lysine(out) = cadaverine(out) + L-lysine(in)"}
{"X":30794,"RHEA_ID":28896,"DIRECTION":"LR","MASTER_ID":28895,"ecocyc":"TRANS-RXN-68","compounds":"cadaverine(in) + L-lysine(out) => cadaverine(out) + L-lysine(in)"}
{"X":30795,"RHEA_ID":38769,"compounds":"1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-hexadecanoyl-sn-glycero-3-phosphocholine => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}
{"X":30796,"RHEA_ID":28898,"compounds":"cadaverine(in) + L-lysine(out) <=> cadaverine(out) + L-lysine(in)"}
{"X":30797,"RHEA_ID":28899,"compounds":"glycine(in) + H(+)(in) = glycine(out) + H(+)(out)"}
{"X":30798,"RHEA_ID":28900,"DIRECTION":"LR","MASTER_ID":28899,"reactome":"R-HSA-375405.1","compounds":"glycine(in) + H(+)(in) => glycine(out) + H(+)(out)"}
{"X":30799,"RHEA_ID":28900,"DIRECTION":"LR","MASTER_ID":28899,"reactome":"R-HSA-375417.1","compounds":"glycine(in) + H(+)(in) => glycine(out) + H(+)(out)"}
{"X":30800,"RHEA_ID":38774,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":30801,"RHEA_ID":28902,"compounds":"glycine(in) + H(+)(in) <=> glycine(out) + H(+)(out)"}
{"X":30802,"RHEA_ID":28903,"compounds":"D-alanine(in) + H(+)(in) = D-alanine(out) + H(+)(out)"}
{"X":30803,"RHEA_ID":28904,"compounds":"D-alanine(in) + H(+)(in) => D-alanine(out) + H(+)(out)"}
{"X":30804,"RHEA_ID":38778,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine"}
{"X":30805,"RHEA_ID":28906,"compounds":"D-alanine(in) + H(+)(in) <=> D-alanine(out) + H(+)(out)"}
{"X":30806,"RHEA_ID":28907,"compounds":"3-(3-hydroxyphenyl)propanoate(in) + H(+)(in) = 3-(3-hydroxyphenyl)propanoate(out) + H(+)(out)"}
{"X":30807,"RHEA_ID":28908,"compounds":"3-(3-hydroxyphenyl)propanoate(in) + H(+)(in) => 3-(3-hydroxyphenyl)propanoate(out) + H(+)(out)"}
{"X":30808,"RHEA_ID":38782,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":30809,"RHEA_ID":28910,"compounds":"3-(3-hydroxyphenyl)propanoate(in) + H(+)(in) <=> 3-(3-hydroxyphenyl)propanoate(out) + H(+)(out)"}
{"X":30810,"RHEA_ID":28911,"compounds":"H(+)(out) + L-lysine(out) = H(+)(in) + L-lysine(in)"}
{"X":30811,"RHEA_ID":28912,"compounds":"H(+)(out) + L-lysine(out) => H(+)(in) + L-lysine(in)"}
{"X":30812,"RHEA_ID":38786,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":30813,"RHEA_ID":28914,"compounds":"H(+)(out) + L-lysine(out) <=> H(+)(in) + L-lysine(in)"}
{"X":30814,"RHEA_ID":28915,"compounds":"4-aminobutanoate(in) + H(+)(in) = 4-aminobutanoate(out) + H(+)(out)"}
{"X":30815,"RHEA_ID":28916,"compounds":"4-aminobutanoate(in) + H(+)(in) => 4-aminobutanoate(out) + H(+)(out)"}
{"X":30816,"RHEA_ID":38790,"compounds":"1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":30817,"RHEA_ID":28918,"compounds":"4-aminobutanoate(in) + H(+)(in) <=> 4-aminobutanoate(out) + H(+)(out)"}
{"X":30818,"RHEA_ID":28919,"compounds":"4-aminobutanoate(in) + L-glutamate(out) = 4-aminobutanoate(out) + L-glutamate(in)"}
{"X":30819,"RHEA_ID":28920,"DIRECTION":"LR","MASTER_ID":28919,"ecocyc":"TRANS-RXN-261","compounds":"4-aminobutanoate(in) + L-glutamate(out) => 4-aminobutanoate(out) + L-glutamate(in)"}
{"X":30820,"RHEA_ID":28921,"compounds":"4-aminobutanoate(out) + L-glutamate(in) => 4-aminobutanoate(in) + L-glutamate(out)"}
{"X":30821,"RHEA_ID":28922,"compounds":"4-aminobutanoate(in) + L-glutamate(out) <=> 4-aminobutanoate(out) + L-glutamate(in)"}
{"X":30822,"RHEA_ID":28923,"compounds":"H(+)(in) + L-phenylalanine(in) = H(+)(out) + L-phenylalanine(out)"}
{"X":30823,"RHEA_ID":28924,"compounds":"H(+)(in) + L-phenylalanine(in) => H(+)(out) + L-phenylalanine(out)"}
{"X":30824,"RHEA_ID":38798,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine"}
{"X":30825,"RHEA_ID":28926,"compounds":"H(+)(in) + L-phenylalanine(in) <=> H(+)(out) + L-phenylalanine(out)"}
{"X":30826,"RHEA_ID":28927,"DIRECTION":"UN","MASTER_ID":28927,"ec":"1.13.11.57","compounds":"3,4,5-trihydroxybenzoate + O2 = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + 2 H(+)"}
{"X":30827,"RHEA_ID":28928,"DIRECTION":"LR","MASTER_ID":28927,"metacyc":"GALLATE-DIOXYGENASE-RXN","compounds":"3,4,5-trihydroxybenzoate + O2 => (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + 2 H(+)"}
{"X":30828,"RHEA_ID":38802,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}
{"X":30829,"RHEA_ID":38803,"compounds":"1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}
{"X":30830,"RHEA_ID":28931,"DIRECTION":"UN","MASTER_ID":28931,"ec":"5.3.2.8","compounds":"(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate = 4-carboxy-2-hydroxy-cis,cis-muconate"}
{"X":30831,"RHEA_ID":28932,"compounds":"(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate => 4-carboxy-2-hydroxy-cis,cis-muconate"}
{"X":30832,"RHEA_ID":28933,"compounds":"4-carboxy-2-hydroxy-cis,cis-muconate => (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate"}
{"X":30833,"RHEA_ID":38807,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":30834,"RHEA_ID":28935,"DIRECTION":"UN","MASTER_ID":28935,"ec":"4.1.3.17","compounds":"2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = oxaloacetate + pyruvate"}
{"X":30835,"RHEA_ID":28936,"compounds":"2-hydroxy-4-oxobutane-1,2,4-tricarboxylate => oxaloacetate + pyruvate"}
{"X":30836,"RHEA_ID":38810,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":30837,"RHEA_ID":38811,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine"}
{"X":30838,"RHEA_ID":28939,"compounds":"H(+)(in) + xanthosine(in) = H(+)(out) + xanthosine(out)"}
{"X":30839,"RHEA_ID":28940,"compounds":"H(+)(in) + xanthosine(in) => H(+)(out) + xanthosine(out)"}
{"X":30840,"RHEA_ID":38814,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine"}
{"X":30841,"RHEA_ID":28942,"compounds":"H(+)(in) + xanthosine(in) <=> H(+)(out) + xanthosine(out)"}
{"X":30842,"RHEA_ID":28943,"compounds":"betaine(in) = betaine(out)"}
{"X":30843,"RHEA_ID":28944,"compounds":"betaine(in) => betaine(out)"}
{"X":30844,"RHEA_ID":28945,"DIRECTION":"RL","MASTER_ID":28943,"ecocyc":"TRANS-RXN-29A","reactome":"R-HSA-6797957.1","compounds":"betaine(out) => betaine(in)"}
{"X":30845,"RHEA_ID":28946,"compounds":"betaine(in) <=> betaine(out)"}
{"X":30846,"RHEA_ID":28947,"compounds":"H(+)(out) + L-arabinose(in) = H(+)(in) + L-arabinose(out)"}
{"X":30847,"RHEA_ID":28948,"compounds":"H(+)(out) + L-arabinose(in) => H(+)(in) + L-arabinose(out)"}
{"X":30848,"RHEA_ID":38822,"compounds":"1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":30849,"RHEA_ID":28950,"compounds":"H(+)(out) + L-arabinose(in) <=> H(+)(in) + L-arabinose(out)"}
{"X":30850,"RHEA_ID":28951,"compounds":"H(+)(in) + L-arabinose(in) = H(+)(out) + L-arabinose(out)"}
{"X":30851,"RHEA_ID":28952,"compounds":"H(+)(in) + L-arabinose(in) => H(+)(out) + L-arabinose(out)"}
{"X":30852,"RHEA_ID":38826,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":30853,"RHEA_ID":28954,"compounds":"H(+)(in) + L-arabinose(in) <=> H(+)(out) + L-arabinose(out)"}
{"X":30854,"RHEA_ID":28955,"compounds":"D-glucuronate(in) + H(+)(in) = D-glucuronate(out) + H(+)(out)"}
{"X":30855,"RHEA_ID":28956,"compounds":"D-glucuronate(in) + H(+)(in) => D-glucuronate(out) + H(+)(out)"}
{"X":30856,"RHEA_ID":28957,"DIRECTION":"RL","MASTER_ID":28955,"ecocyc":"TRANS-RXN-35","compounds":"D-glucuronate(out) + H(+)(out) => D-glucuronate(in) + H(+)(in)"}
{"X":30857,"RHEA_ID":28958,"compounds":"D-glucuronate(in) + H(+)(in) <=> D-glucuronate(out) + H(+)(out)"}
{"X":30858,"RHEA_ID":28959,"compounds":"D-xylose(in) + H(+)(in) = D-xylose(out) + H(+)(out)"}
{"X":30859,"RHEA_ID":28960,"compounds":"D-xylose(in) + H(+)(in) => D-xylose(out) + H(+)(out)"}
{"X":30860,"RHEA_ID":38834,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine"}
{"X":30861,"RHEA_ID":28962,"compounds":"D-xylose(in) + H(+)(in) <=> D-xylose(out) + H(+)(out)"}
{"X":30862,"RHEA_ID":28963,"compounds":"H(+)(out) + L-proline(out) = H(+)(in) + L-proline(in)"}
{"X":30863,"RHEA_ID":28964,"compounds":"H(+)(out) + L-proline(out) => H(+)(in) + L-proline(in)"}
{"X":30864,"RHEA_ID":28965,"DIRECTION":"RL","MASTER_ID":28963,"ecocyc":"TRANS-RXN-29","reactome":"R-HSA-375417.1","compounds":"H(+)(in) + L-proline(in) => H(+)(out) + L-proline(out)"}
{"X":30865,"RHEA_ID":28965,"DIRECTION":"RL","MASTER_ID":28963,"ecocyc":"TRANS-RXN-29","reactome":"R-HSA-375405.1","compounds":"H(+)(in) + L-proline(in) => H(+)(out) + L-proline(out)"}
{"X":30866,"RHEA_ID":28966,"compounds":"H(+)(out) + L-proline(out) <=> H(+)(in) + L-proline(in)"}
{"X":30867,"RHEA_ID":28967,"compounds":"L-proline(in) + Na(+)(in) = L-proline(out) + Na(+)(out)"}
{"X":30868,"RHEA_ID":28968,"DIRECTION":"LR","MASTER_ID":28967,"reactome":"R-HSA-352059.1","compounds":"L-proline(in) + Na(+)(in) => L-proline(out) + Na(+)(out)"}
{"X":30869,"RHEA_ID":38843,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine"}
{"X":30870,"RHEA_ID":28968,"DIRECTION":"LR","MASTER_ID":28967,"reactome":"R-HSA-352052.2","compounds":"L-proline(in) + Na(+)(in) => L-proline(out) + Na(+)(out)"}
{"X":30871,"RHEA_ID":28969,"DIRECTION":"RL","MASTER_ID":28967,"ecocyc":"TRANS-RXN-118","compounds":"L-proline(out) + Na(+)(out) => L-proline(in) + Na(+)(in)"}
{"X":30872,"RHEA_ID":28970,"compounds":"L-proline(in) + Na(+)(in) <=> L-proline(out) + Na(+)(out)"}
{"X":30873,"RHEA_ID":38847,"compounds":"1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":30874,"RHEA_ID":28972,"compounds":"H(+)(in) + shikimate(in) => H(+)(out) + shikimate(out)"}
{"X":30875,"RHEA_ID":28973,"DIRECTION":"RL","MASTER_ID":28971,"ecocyc":"TRANS-RXN-27","compounds":"H(+)(out) + shikimate(out) => H(+)(in) + shikimate(in)"}
{"X":30876,"RHEA_ID":28974,"compounds":"H(+)(in) + shikimate(in) <=> H(+)(out) + shikimate(out)"}
{"X":30877,"RHEA_ID":38851,"DIRECTION":"UN","MASTER_ID":38851,"ec":"4.2.1.154","compounds":"H(+) + tetracenomycin F2 = H2O + tetracenomycin F1"}
{"X":30878,"RHEA_ID":28976,"compounds":"H(+)(out) + L-asparagine(in) => H(+)(in) + L-asparagine(out)"}
{"X":30879,"RHEA_ID":28977,"DIRECTION":"RL","MASTER_ID":28975,"ecocyc":"TRANS-RXN-262","compounds":"H(+)(in) + L-asparagine(out) => H(+)(out) + L-asparagine(in)"}
{"X":30880,"RHEA_ID":28978,"compounds":"H(+)(out) + L-asparagine(in) <=> H(+)(in) + L-asparagine(out)"}
{"X":30881,"RHEA_ID":38855,"compounds":"2 [Fe(II)-cytochrome b5] + a 1,2-saturated fatty acid + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a (R)-2-hydroxy fatty acid + H2O"}
{"X":30882,"RHEA_ID":28980,"DIRECTION":"LR","MASTER_ID":28979,"ecocyc":"TRANS-RXN-26","compounds":"H(+)(out) + nitrite(in) => H(+)(in) + nitrite(out)"}
{"X":30883,"RHEA_ID":28981,"compounds":"H(+)(in) + nitrite(out) => H(+)(out) + nitrite(in)"}
{"X":30884,"RHEA_ID":28982,"compounds":"H(+)(out) + nitrite(in) <=> H(+)(in) + nitrite(out)"}
{"X":30885,"RHEA_ID":38859,"DIRECTION":"UN","MASTER_ID":38859,"ec":"2.4.1.330","compounds":"beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP-alpha-D-glucose = bis(beta-D-gentiobiosyl) crocetin + H(+) + UDP"}
{"X":30886,"RHEA_ID":28984,"compounds":"nitrite(in) => nitrite(out)"}
{"X":30887,"RHEA_ID":28985,"DIRECTION":"RL","MASTER_ID":28983,"ecocyc":"TRANS-RXN-137","compounds":"nitrite(out) => nitrite(in)"}
{"X":30888,"RHEA_ID":28986,"compounds":"nitrite(in) <=> nitrite(out)"}
{"X":30889,"RHEA_ID":38863,"DIRECTION":"UN","MASTER_ID":38863,"ec":"2.4.1.329","compounds":"phosphate + sucrose 6(F)-phosphate = alpha-D-glucose 1-phosphate + beta-D-fructose 6-phosphate"}
{"X":30890,"RHEA_ID":28988,"compounds":"H(+)(in) + N-acetylneuraminate(in) => H(+)(out) + N-acetylneuraminate(out)"}
{"X":30891,"RHEA_ID":28989,"DIRECTION":"RL","MASTER_ID":28987,"ecocyc":"TRANS-RXN-25","reactome":"R-HSA-428585.1","compounds":"H(+)(out) + N-acetylneuraminate(out) => H(+)(in) + N-acetylneuraminate(in)"}
{"X":30892,"RHEA_ID":28990,"compounds":"H(+)(in) + N-acetylneuraminate(in) <=> H(+)(out) + N-acetylneuraminate(out)"}
{"X":30893,"RHEA_ID":28991,"compounds":"N-acetylneuraminate(in) = N-acetylneuraminate(out)"}
{"X":30894,"RHEA_ID":28992,"compounds":"N-acetylneuraminate(in) => N-acetylneuraminate(out)"}
{"X":30895,"RHEA_ID":28993,"DIRECTION":"RL","MASTER_ID":28991,"ecocyc":"RXN0-0","reactome":"R-HSA-4085020.1","compounds":"N-acetylneuraminate(out) => N-acetylneuraminate(in)"}
{"X":30896,"RHEA_ID":28994,"compounds":"N-acetylneuraminate(in) <=> N-acetylneuraminate(out)"}
{"X":30897,"RHEA_ID":38871,"DIRECTION":"UN","MASTER_ID":38871,"ec":"5.4.99.20","compounds":"23S rRNA uridine(2457) = pseudouridine(2457) in 23S rRNA"}
{"X":30898,"RHEA_ID":38872,"DIRECTION":"LR","MASTER_ID":38871,"ecocyc":"RXN-11834","metacyc":"RXN-11834","compounds":"23S rRNA uridine(2457) => pseudouridine(2457) in 23S rRNA"}
{"X":30899,"RHEA_ID":28997,"compounds":"H(+)(in) + L-threonine(out) => H(+)(out) + L-threonine(in)"}
{"X":30900,"RHEA_ID":28998,"compounds":"H(+)(out) + L-threonine(in) <=> H(+)(in) + L-threonine(out)"}
{"X":30901,"RHEA_ID":28999,"compounds":"H(+)(out) + homoserine lactone(in) = H(+)(in) + homoserine lactone(out)"}
{"X":30902,"RHEA_ID":29000,"DIRECTION":"LR","MASTER_ID":28999,"ecocyc":"TRANS-RXN-242A","compounds":"H(+)(out) + homoserine lactone(in) => H(+)(in) + homoserine lactone(out)"}
{"X":30903,"RHEA_ID":29001,"compounds":"H(+)(in) + homoserine lactone(out) => H(+)(out) + homoserine lactone(in)"}
{"X":30904,"RHEA_ID":29002,"compounds":"H(+)(out) + homoserine lactone(in) <=> H(+)(in) + homoserine lactone(out)"}
{"X":30905,"RHEA_ID":29003,"compounds":"H(+)(out) + L-homoserine(in) = H(+)(in) + L-homoserine(out)"}
{"X":30906,"RHEA_ID":38880,"compounds":"a fatty acid(in) => a fatty acid(out)"}
{"X":30907,"RHEA_ID":29005,"compounds":"H(+)(in) + L-homoserine(out) => H(+)(out) + L-homoserine(in)"}
{"X":30908,"RHEA_ID":29006,"compounds":"H(+)(out) + L-homoserine(in) <=> H(+)(in) + L-homoserine(out)"}
{"X":30909,"RHEA_ID":29007,"compounds":"H(+)(in) + Mn(2+)(in) = H(+)(out) + Mn(2+)(out)"}
{"X":30910,"RHEA_ID":29008,"compounds":"H(+)(in) + Mn(2+)(in) => H(+)(out) + Mn(2+)(out)"}
{"X":30911,"RHEA_ID":29009,"DIRECTION":"RL","MASTER_ID":29007,"ecocyc":"TRANS-RXN-241","compounds":"H(+)(out) + Mn(2+)(out) => H(+)(in) + Mn(2+)(in)"}
{"X":30912,"RHEA_ID":29010,"compounds":"H(+)(in) + Mn(2+)(in) <=> H(+)(out) + Mn(2+)(out)"}
{"X":30913,"RHEA_ID":29011,"compounds":"2-oxoglutarate(in) + H(+)(in) = 2-oxoglutarate(out) + H(+)(out)"}
{"X":30914,"RHEA_ID":38888,"compounds":"H2O + N-hexanoyl-sphinganine => hexanoate + sphinganine"}
{"X":30915,"RHEA_ID":29013,"DIRECTION":"RL","MASTER_ID":29011,"ecocyc":"TRANS-RXN-23","compounds":"2-oxoglutarate(out) + H(+)(out) => 2-oxoglutarate(in) + H(+)(in)"}
{"X":30916,"RHEA_ID":29014,"compounds":"2-oxoglutarate(in) + H(+)(in) <=> 2-oxoglutarate(out) + H(+)(out)"}
{"X":30917,"RHEA_ID":29015,"compounds":"phosphate(out) + sn-glycerol 3-phosphate(in) = phosphate(in) + sn-glycerol 3-phosphate(out)"}
{"X":30918,"RHEA_ID":38892,"compounds":"H2O + N-hexadecanoylsphing-4-enine => hexadecanoate + sphing-4-enine"}
{"X":30919,"RHEA_ID":29017,"DIRECTION":"RL","MASTER_ID":29015,"ecocyc":"TRANS-RXN-22","compounds":"phosphate(in) + sn-glycerol 3-phosphate(out) => phosphate(out) + sn-glycerol 3-phosphate(in)"}
{"X":30920,"RHEA_ID":29018,"compounds":"phosphate(out) + sn-glycerol 3-phosphate(in) <=> phosphate(in) + sn-glycerol 3-phosphate(out)"}
{"X":30921,"RHEA_ID":29019,"compounds":"D-galactose(in) + H(+)(in) = D-galactose(out) + H(+)(out)"}
{"X":30922,"RHEA_ID":38896,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)"}
{"X":30923,"RHEA_ID":29021,"DIRECTION":"RL","MASTER_ID":29019,"ecocyc":"TRANS-RXN-21","compounds":"D-galactose(out) + H(+)(out) => D-galactose(in) + H(+)(in)"}
{"X":30924,"RHEA_ID":29022,"compounds":"D-galactose(in) + H(+)(in) <=> D-galactose(out) + H(+)(out)"}
{"X":30925,"RHEA_ID":29023,"compounds":"H(+)(in) + L-fucose(in) = H(+)(out) + L-fucose(out)"}
{"X":30926,"RHEA_ID":38900,"compounds":"a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(out) => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(in)"}
{"X":30927,"RHEA_ID":29025,"DIRECTION":"RL","MASTER_ID":29023,"ecocyc":"TRANS-RXN-20","compounds":"H(+)(out) + L-fucose(out) => H(+)(in) + L-fucose(in)"}
{"X":30928,"RHEA_ID":29026,"compounds":"H(+)(in) + L-fucose(in) <=> H(+)(out) + L-fucose(out)"}
{"X":30929,"RHEA_ID":29027,"compounds":"2 H(+)(in) + L-glutamate(in) = 2 H(+)(out) + L-glutamate(out)"}
{"X":30930,"RHEA_ID":38904,"compounds":"ATP + H2O + sphingomyelin(in) => ADP + H(+) + phosphate + sphingomyelin(out)"}
{"X":30931,"RHEA_ID":29029,"DIRECTION":"RL","MASTER_ID":29027,"ecocyc":"TRANS-RXN-162","compounds":"2 H(+)(out) + L-glutamate(out) => 2 H(+)(in) + L-glutamate(in)"}
{"X":30932,"RHEA_ID":29030,"compounds":"2 H(+)(in) + L-glutamate(in) <=> 2 H(+)(out) + L-glutamate(out)"}
{"X":30933,"RHEA_ID":29031,"compounds":"L-glutamate(in) + Na(+)(in) = L-glutamate(out) + Na(+)(out)"}
{"X":30934,"RHEA_ID":38908,"DIRECTION":"LR","MASTER_ID":38907,"metacyc":"RXN-8701","compounds":"(R)-reticuline + S-adenosyl-L-methionine => (R)-laudanine + H(+) + S-adenosyl-L-homocysteine"}
{"X":30935,"RHEA_ID":29033,"DIRECTION":"RL","MASTER_ID":29031,"ecocyc":"TRANS-RXN-122","compounds":"L-glutamate(out) + Na(+)(out) => L-glutamate(in) + Na(+)(in)"}
{"X":30936,"RHEA_ID":29034,"compounds":"L-glutamate(in) + Na(+)(in) <=> L-glutamate(out) + Na(+)(out)"}
{"X":30937,"RHEA_ID":29035,"compounds":"ATP + H2O + L-glutamate(out) = ADP + H(+) + L-glutamate(in) + phosphate"}
{"X":30938,"RHEA_ID":38912,"DIRECTION":"LR","MASTER_ID":38911,"metacyc":"RXN-14980","compounds":"avenacoside B + H2O => 26-desgluco-avenacoside B + D-glucose"}
{"X":30939,"RHEA_ID":29037,"compounds":"ADP + H(+) + L-glutamate(in) + phosphate => ATP + H2O + L-glutamate(out)"}
{"X":30940,"RHEA_ID":29038,"compounds":"ATP + H2O + L-glutamate(out) <=> ADP + H(+) + L-glutamate(in) + phosphate"}
{"X":30941,"RHEA_ID":29039,"compounds":"ATP + H2O + L-aspartate(out) = ADP + H(+) + L-aspartate(in) + phosphate"}
{"X":30942,"RHEA_ID":38916,"compounds":"a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + choline + H(+)"}
{"X":30943,"RHEA_ID":29041,"compounds":"ADP + H(+) + L-aspartate(in) + phosphate => ATP + H2O + L-aspartate(out)"}
{"X":30944,"RHEA_ID":29042,"compounds":"ATP + H2O + L-aspartate(out) <=> ADP + H(+) + L-aspartate(in) + phosphate"}
{"X":30945,"RHEA_ID":29043,"DIRECTION":"UN","MASTER_ID":29043,"ec":"2.1.1.148","compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH = (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+)"}
{"X":30946,"RHEA_ID":38920,"compounds":"H2O + sphing-4-enine-phosphocholine => choline + H(+) + sphing-4-enine 1-phosphate"}
{"X":30947,"RHEA_ID":38921,"compounds":"choline + H(+) + sphing-4-enine 1-phosphate => H2O + sphing-4-enine-phosphocholine"}
{"X":30948,"RHEA_ID":38922,"compounds":"H2O + sphing-4-enine-phosphocholine <=> choline + H(+) + sphing-4-enine 1-phosphate"}
{"X":30949,"RHEA_ID":29047,"compounds":"a menaquinone + 2 H(+)(in) + H2 = a menaquinol + 2 H(+)(out)"}
{"X":30950,"RHEA_ID":29048,"DIRECTION":"LR","MASTER_ID":29047,"ecocyc":"RXN0-5256","metacyc":"RXN0-5256","compounds":"a menaquinone + 2 H(+)(in) + H2 => a menaquinol + 2 H(+)(out)"}
{"X":30951,"RHEA_ID":38925,"compounds":"a ubiquinol + Na(+)(out) + NAD(+) => a ubiquinone + H(+) + Na(+)(in) + NADH"}
{"X":30952,"RHEA_ID":29051,"compounds":"2 H(+)(in) + H2 + menaquinone-8 = 2 H(+)(out) + menaquinol-8"}
{"X":30953,"RHEA_ID":29052,"compounds":"2 H(+)(in) + H2 + menaquinone-8 => 2 H(+)(out) + menaquinol-8"}
{"X":30954,"RHEA_ID":29053,"compounds":"2 H(+)(out) + menaquinol-8 => 2 H(+)(in) + H2 + menaquinone-8"}
{"X":30955,"RHEA_ID":29054,"compounds":"2 H(+)(in) + H2 + menaquinone-8 <=> 2 H(+)(out) + menaquinol-8"}
{"X":30956,"RHEA_ID":29055,"compounds":"a ubiquinone + 2 H(+)(in) + H2 = a ubiquinol + 2 H(+)(out)"}
{"X":30957,"RHEA_ID":29056,"compounds":"a ubiquinone + 2 H(+)(in) + H2 => a ubiquinol + 2 H(+)(out)"}
{"X":30958,"RHEA_ID":38933,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + L-serine => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O"}
{"X":30959,"RHEA_ID":29058,"compounds":"a ubiquinone + 2 H(+)(in) + H2 <=> a ubiquinol + 2 H(+)(out)"}
{"X":30960,"RHEA_ID":29059,"compounds":"2 H(+)(in) + H2 + ubiquinone-8 = 2 H(+)(out) + ubiquinol-8"}
{"X":30961,"RHEA_ID":29060,"compounds":"2 H(+)(in) + H2 + ubiquinone-8 => 2 H(+)(out) + ubiquinol-8"}
{"X":30962,"RHEA_ID":38937,"compounds":"cyclohex-1-ene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein] => cyclohexane-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":30963,"RHEA_ID":29062,"compounds":"2 H(+)(in) + H2 + ubiquinone-8 <=> 2 H(+)(out) + ubiquinol-8"}
{"X":30964,"RHEA_ID":29063,"DIRECTION":"UN","MASTER_ID":29063,"ec":"1.17.5.3","compounds":"a menaquinone + formate + H(+) = a menaquinol + CO2"}
{"X":30965,"RHEA_ID":29064,"DIRECTION":"LR","MASTER_ID":29063,"ecocyc":"FORMATEDEHYDROG-RXN","metacyc":"FORMATEDEHYDROG-RXN","compounds":"a menaquinone + formate + H(+) => a menaquinol + CO2"}
{"X":30966,"RHEA_ID":38941,"compounds":"diosgenin 3-beta-D-glucoside + 2 L-rhamnopyranose => dioscin + 2 H2O"}
{"X":30967,"RHEA_ID":29066,"compounds":"a menaquinone + formate + H(+) <=> a menaquinol + CO2"}
{"X":30968,"RHEA_ID":29067,"DIRECTION":"UN","MASTER_ID":29067,"ec":"1.17.5.3","compounds":"formate + H(+) + menaquinone-8 = CO2 + menaquinol-8"}
{"X":30969,"RHEA_ID":29068,"compounds":"formate + H(+) + menaquinone-8 => CO2 + menaquinol-8"}
{"X":30970,"RHEA_ID":38945,"compounds":"a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ADP + H(+) + phosphate => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ATP + H2O"}
{"X":30971,"RHEA_ID":29070,"compounds":"formate + H(+) + menaquinone-8 <=> CO2 + menaquinol-8"}
{"X":30972,"RHEA_ID":29071,"DIRECTION":"UN","MASTER_ID":29071,"ec":"1.17.5.3","compounds":"a ubiquinone + formate + H(+) = a ubiquinol + CO2"}
{"X":30973,"RHEA_ID":29072,"compounds":"a ubiquinone + formate + H(+) => a ubiquinol + CO2"}
{"X":30974,"RHEA_ID":38949,"compounds":"12-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":30975,"RHEA_ID":29074,"compounds":"a ubiquinone + formate + H(+) <=> a ubiquinol + CO2"}
{"X":30976,"RHEA_ID":29075,"compounds":"formate(out) + 2 H(+)(in) + ubiquinone-8 = CO2(out) + H(+)(out) + ubiquinol-8"}
{"X":30977,"RHEA_ID":29076,"compounds":"formate(out) + 2 H(+)(in) + ubiquinone-8 => CO2(out) + H(+)(out) + ubiquinol-8"}
{"X":30978,"RHEA_ID":29077,"compounds":"CO2(out) + H(+)(out) + ubiquinol-8 => formate(out) + 2 H(+)(in) + ubiquinone-8"}
{"X":30979,"RHEA_ID":29078,"compounds":"formate(out) + 2 H(+)(in) + ubiquinone-8 <=> CO2(out) + H(+)(out) + ubiquinol-8"}
{"X":30980,"RHEA_ID":29079,"compounds":"(R)-lactate + ubiquinone-8 = pyruvate + ubiquinol-8"}
{"X":30981,"RHEA_ID":29080,"compounds":"(R)-lactate + ubiquinone-8 => pyruvate + ubiquinol-8"}
{"X":30982,"RHEA_ID":38957,"compounds":"N-acylsphing-4-enine 1-phosphate(out) => N-acylsphing-4-enine 1-phosphate(in)"}
{"X":30983,"RHEA_ID":29082,"compounds":"(R)-lactate + ubiquinone-8 <=> pyruvate + ubiquinol-8"}
{"X":30984,"RHEA_ID":29083,"compounds":"(S)-malate + ubiquinone-8 = oxaloacetate + ubiquinol-8"}
{"X":30985,"RHEA_ID":29084,"compounds":"(S)-malate + ubiquinone-8 => oxaloacetate + ubiquinol-8"}
{"X":30986,"RHEA_ID":38960,"DIRECTION":"LR","MASTER_ID":38959,"metacyc":"RXN-11026","compounds":"a 2,3-saturated acyl-CoA + O2 => a (2E)-enoyl-CoA + H2O2"}
{"X":30987,"RHEA_ID":29086,"compounds":"(S)-malate + ubiquinone-8 <=> oxaloacetate + ubiquinol-8"}
{"X":30988,"RHEA_ID":29087,"compounds":"(S)-malate + menaquinone-8 = menaquinol-8 + oxaloacetate"}
{"X":30989,"RHEA_ID":29088,"compounds":"(S)-malate + menaquinone-8 => menaquinol-8 + oxaloacetate"}
{"X":30990,"RHEA_ID":38964,"compounds":"ATP + H2O + leukotriene C4(in) => ADP + H(+) + leukotriene C4(out) + phosphate"}
{"X":30991,"RHEA_ID":29090,"compounds":"(S)-malate + menaquinone-8 <=> menaquinol-8 + oxaloacetate"}
{"X":30992,"RHEA_ID":29091,"DIRECTION":"UN","MASTER_ID":29091,"ec":"7.1.1.2","compounds":"a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+)"}
{"X":30993,"RHEA_ID":29092,"compounds":"a ubiquinone + 5 H(+)(in) + NADH => a ubiquinol + 4 H(+)(out) + NAD(+)"}
{"X":30994,"RHEA_ID":29093,"compounds":"a ubiquinol + 4 H(+)(out) + NAD(+) => a ubiquinone + 5 H(+)(in) + NADH"}
{"X":30995,"RHEA_ID":29095,"compounds":"5 H(+)(in) + NADH + ubiquinone-8 = 4 H(+)(out) + NAD(+) + ubiquinol-8"}
{"X":30996,"RHEA_ID":29096,"compounds":"5 H(+)(in) + NADH + ubiquinone-8 => 4 H(+)(out) + NAD(+) + ubiquinol-8"}
{"X":30997,"RHEA_ID":29097,"compounds":"4 H(+)(out) + NAD(+) + ubiquinol-8 => 5 H(+)(in) + NADH + ubiquinone-8"}
{"X":30998,"RHEA_ID":29098,"compounds":"5 H(+)(in) + NADH + ubiquinone-8 <=> 4 H(+)(out) + NAD(+) + ubiquinol-8"}
{"X":30999,"RHEA_ID":29099,"compounds":"a menaquinone + 5 H(+)(in) + NADH = a menaquinol + 4 H(+)(out) + NAD(+)"}
{"X":31000,"RHEA_ID":29100,"compounds":"a menaquinone + 5 H(+)(in) + NADH => a menaquinol + 4 H(+)(out) + NAD(+)"}
{"X":31001,"RHEA_ID":38976,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)"}
{"X":31002,"RHEA_ID":29102,"compounds":"a menaquinone + 5 H(+)(in) + NADH <=> a menaquinol + 4 H(+)(out) + NAD(+)"}
{"X":31003,"RHEA_ID":29103,"compounds":"5 H(+)(in) + menaquinone-8 + NADH = 4 H(+)(out) + menaquinol-8 + NAD(+)"}
{"X":31004,"RHEA_ID":29104,"compounds":"5 H(+)(in) + menaquinone-8 + NADH => 4 H(+)(out) + menaquinol-8 + NAD(+)"}
{"X":31005,"RHEA_ID":38980,"compounds":"1-octadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphate + choline + H(+)"}
{"X":31006,"RHEA_ID":29106,"compounds":"5 H(+)(in) + menaquinone-8 + NADH <=> 4 H(+)(out) + menaquinol-8 + NAD(+)"}
{"X":31007,"RHEA_ID":29107,"compounds":"H(+) + NADH + ubiquinone-8 = NAD(+) + ubiquinol-8"}
{"X":31008,"RHEA_ID":29108,"compounds":"H(+) + NADH + ubiquinone-8 => NAD(+) + ubiquinol-8"}
{"X":31009,"RHEA_ID":38984,"compounds":"1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O => 1-tetradecanoyl-sn-glycerol 3-phosphate + choline + H(+)"}
{"X":31010,"RHEA_ID":29110,"compounds":"H(+) + NADH + ubiquinone-8 <=> NAD(+) + ubiquinol-8"}
{"X":31011,"RHEA_ID":29111,"compounds":"H(+) + NADPH + ubiquinone-8 = NADP(+) + ubiquinol-8"}
{"X":31012,"RHEA_ID":29112,"compounds":"H(+) + NADPH + ubiquinone-8 => NADP(+) + ubiquinol-8"}
{"X":31013,"RHEA_ID":38988,"compounds":"nonanoyl-CoA + O2 => (2E)-nonenoyl-CoA + H2O2"}
{"X":31014,"RHEA_ID":29114,"compounds":"H(+) + NADPH + ubiquinone-8 <=> NADP(+) + ubiquinol-8"}
{"X":31015,"RHEA_ID":29115,"compounds":"H(+) + menaquinone-8 + NADPH = menaquinol-8 + NADP(+)"}
{"X":31016,"RHEA_ID":29116,"compounds":"H(+) + menaquinone-8 + NADPH => menaquinol-8 + NADP(+)"}
{"X":31017,"RHEA_ID":38992,"compounds":"1-dodecanoyl-sn-glycero-3-phosphocholine + H2O => 1-dodecanoyl-sn-glycerol 3-phosphate + choline + H(+)"}
{"X":31018,"RHEA_ID":29118,"compounds":"H(+) + menaquinone-8 + NADPH <=> menaquinol-8 + NADP(+)"}
{"X":31019,"RHEA_ID":29119,"compounds":"a ubiquinol + nitrate = a ubiquinone + H2O + nitrite"}
{"X":31020,"RHEA_ID":29120,"DIRECTION":"LR","MASTER_ID":29119,"ecocyc":"RXN0-6369","metacyc":"RXN0-6369","compounds":"a ubiquinol + nitrate => a ubiquinone + H2O + nitrite"}
{"X":31021,"RHEA_ID":38996,"compounds":"a 1-acyl-sn-glycero-3-phosphocholine + H2O => a 1-acyl-sn-glycero-3-phosphate + choline + H(+)"}
{"X":31022,"RHEA_ID":29123,"compounds":"nitrate(out) + ubiquinol-8(in) = H2O(out) + nitrite(out) + ubiquinone-8(in)"}
{"X":31023,"RHEA_ID":29124,"compounds":"nitrate(out) + ubiquinol-8(in) => H2O(out) + nitrite(out) + ubiquinone-8(in)"}
{"X":31024,"RHEA_ID":29125,"compounds":"H2O(out) + nitrite(out) + ubiquinone-8(in) => nitrate(out) + ubiquinol-8(in)"}
{"X":31025,"RHEA_ID":29126,"compounds":"nitrate(out) + ubiquinol-8(in) <=> H2O(out) + nitrite(out) + ubiquinone-8(in)"}
{"X":31026,"RHEA_ID":29127,"compounds":"a menaquinol + nitrate = a menaquinone + H2O + nitrite"}
{"X":31027,"RHEA_ID":29128,"DIRECTION":"LR","MASTER_ID":29127,"ecocyc":"RXN-16471","metacyc":"RXN-16471","compounds":"a menaquinol + nitrate => a menaquinone + H2O + nitrite"}
{"X":31028,"RHEA_ID":39004,"compounds":"a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O => a 1-acyl-sn-glycero-3-phosphate + ethanolamine + H(+)"}
{"X":31029,"RHEA_ID":29130,"compounds":"a menaquinol + nitrate <=> a menaquinone + H2O + nitrite"}
{"X":31030,"RHEA_ID":29131,"compounds":"menaquinol-8 + nitrate = H2O + menaquinone-8 + nitrite"}
{"X":31031,"RHEA_ID":29132,"compounds":"menaquinol-8 + nitrate => H2O + menaquinone-8 + nitrite"}
{"X":31032,"RHEA_ID":29133,"compounds":"H2O + menaquinone-8 + nitrite => menaquinol-8 + nitrate"}
{"X":31033,"RHEA_ID":29134,"compounds":"menaquinol-8 + nitrate <=> H2O + menaquinone-8 + nitrite"}
{"X":31034,"RHEA_ID":29135,"compounds":"a menaquinol + 2 H(+)(in) + nitrate = a menaquinone + 2 H(+)(out) + H2O + nitrite"}
{"X":31035,"RHEA_ID":29136,"DIRECTION":"LR","MASTER_ID":29135,"ecocyc":"RXN0-3501","metacyc":"RXN0-3501","compounds":"a menaquinol + 2 H(+)(in) + nitrate => a menaquinone + 2 H(+)(out) + H2O + nitrite"}
{"X":31036,"RHEA_ID":39012,"compounds":"a triacyl-sn-glycerol(in) => a triacyl-sn-glycerol(out)"}
{"X":31037,"RHEA_ID":29138,"compounds":"a menaquinol + 2 H(+)(in) + nitrate <=> a menaquinone + 2 H(+)(out) + H2O + nitrite"}
{"X":31038,"RHEA_ID":29139,"compounds":"2 H(+)(in) + menaquinol-8 + nitrate = 2 H(+)(out) + H2O + menaquinone-8 + nitrite"}
{"X":31039,"RHEA_ID":29140,"compounds":"2 H(+)(in) + menaquinol-8 + nitrate => 2 H(+)(out) + H2O + menaquinone-8 + nitrite"}
{"X":31040,"RHEA_ID":39016,"compounds":"22-oxodocosanoate + H2O + NAD(+) => docosanedioate + 2 H(+) + NADH"}
{"X":31041,"RHEA_ID":29142,"compounds":"2 H(+)(in) + menaquinol-8 + nitrate <=> 2 H(+)(out) + H2O + menaquinone-8 + nitrite"}
{"X":31042,"RHEA_ID":29143,"compounds":"a ubiquinol + 2 H(+)(in) + nitrate = a ubiquinone + 2 H(+)(out) + H2O + nitrite"}
{"X":31043,"RHEA_ID":29144,"compounds":"a ubiquinol + 2 H(+)(in) + nitrate => a ubiquinone + 2 H(+)(out) + H2O + nitrite"}
{"X":31044,"RHEA_ID":39020,"DIRECTION":"LR","MASTER_ID":39019,"metacyc":"RXN-10958","compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate"}
{"X":31045,"RHEA_ID":29146,"compounds":"a ubiquinol + 2 H(+)(in) + nitrate <=> a ubiquinone + 2 H(+)(out) + H2O + nitrite"}
{"X":31046,"RHEA_ID":29147,"compounds":"2 H(+)(in) + nitrate + ubiquinol-8 = 2 H(+)(out) + H2O + nitrite + ubiquinone-8"}
{"X":31047,"RHEA_ID":29148,"compounds":"2 H(+)(in) + nitrate + ubiquinol-8 => 2 H(+)(out) + H2O + nitrite + ubiquinone-8"}
{"X":31048,"RHEA_ID":39024,"compounds":"an omega-methyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => an omega-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":31049,"RHEA_ID":29150,"compounds":"2 H(+)(in) + nitrate + ubiquinol-8 <=> 2 H(+)(out) + H2O + nitrite + ubiquinone-8"}
{"X":31050,"RHEA_ID":29151,"compounds":"3 a ubiquinol(in) + 2 H(+)(out) + nitrite(out) = 3 a ubiquinone(in) + 2 H2O(out) + NH4(+)(out)"}
{"X":31051,"RHEA_ID":29152,"compounds":"3 a ubiquinol(in) + 2 H(+)(out) + nitrite(out) => 3 a ubiquinone(in) + 2 H2O(out) + NH4(+)(out)"}
{"X":31052,"RHEA_ID":29153,"compounds":"3 a ubiquinone(in) + 2 H2O(out) + NH4(+)(out) => 3 a ubiquinol(in) + 2 H(+)(out) + nitrite(out)"}
{"X":31053,"RHEA_ID":29154,"compounds":"3 a ubiquinol(in) + 2 H(+)(out) + nitrite(out) <=> 3 a ubiquinone(in) + 2 H2O(out) + NH4(+)(out)"}
{"X":31054,"RHEA_ID":29155,"compounds":"2 H(+)(out) + nitrite(out) + 3 ubiquinol-8(in) = 2 H2O(out) + NH4(+)(out) + 3 ubiquinone-8(in)"}
{"X":31055,"RHEA_ID":29156,"compounds":"2 H(+)(out) + nitrite(out) + 3 ubiquinol-8(in) => 2 H2O(out) + NH4(+)(out) + 3 ubiquinone-8(in)"}
{"X":31056,"RHEA_ID":39032,"compounds":"a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose => a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP"}
{"X":31057,"RHEA_ID":29158,"compounds":"2 H(+)(out) + nitrite(out) + 3 ubiquinol-8(in) <=> 2 H2O(out) + NH4(+)(out) + 3 ubiquinone-8(in)"}
{"X":31058,"RHEA_ID":29159,"compounds":"3 a menaquinol(in) + 2 H(+)(out) + nitrite(out) = 3 a menaquinone(in) + 2 H2O(out) + NH4(+)(out)"}
{"X":31059,"RHEA_ID":29160,"compounds":"3 a menaquinol(in) + 2 H(+)(out) + nitrite(out) => 3 a menaquinone(in) + 2 H2O(out) + NH4(+)(out)"}
{"X":31060,"RHEA_ID":39036,"compounds":"an omega-hydroxy fatty acid + NAD(+) => an omega-oxo fatty acid + H(+) + NADH"}
{"X":31061,"RHEA_ID":29162,"compounds":"3 a menaquinol(in) + 2 H(+)(out) + nitrite(out) <=> 3 a menaquinone(in) + 2 H2O(out) + NH4(+)(out)"}
{"X":31062,"RHEA_ID":29163,"compounds":"2 H(+)(out) + 3 menaquinol-8(in) + nitrite(out) = 2 H2O(out) + 3 menaquinone-8(in) + NH4(+)(out)"}
{"X":31063,"RHEA_ID":29164,"compounds":"2 H(+)(out) + 3 menaquinol-8(in) + nitrite(out) => 2 H2O(out) + 3 menaquinone-8(in) + NH4(+)(out)"}
{"X":31064,"RHEA_ID":29165,"compounds":"2 H2O(out) + 3 menaquinone-8(in) + NH4(+)(out) => 2 H(+)(out) + 3 menaquinol-8(in) + nitrite(out)"}
{"X":31065,"RHEA_ID":29166,"compounds":"2 H(+)(out) + 3 menaquinol-8(in) + nitrite(out) <=> 2 H2O(out) + 3 menaquinone-8(in) + NH4(+)(out)"}
{"X":31066,"RHEA_ID":29167,"compounds":"H2O + pyruvate + ubiquinone-8 = acetate + CO2 + ubiquinol-8"}
{"X":31067,"RHEA_ID":29168,"compounds":"H2O + pyruvate + ubiquinone-8 => acetate + CO2 + ubiquinol-8"}
{"X":31068,"RHEA_ID":29169,"compounds":"acetate + CO2 + ubiquinol-8 => H2O + pyruvate + ubiquinone-8"}
{"X":31069,"RHEA_ID":29171,"DIRECTION":"UN","MASTER_ID":29171,"ec":"1.10.3.17","compounds":"a ubiquinol + 2 O2 = a ubiquinone + 2 H(+) + 2 superoxide"}
{"X":31070,"RHEA_ID":29172,"compounds":"a ubiquinol + 2 O2 => a ubiquinone + 2 H(+) + 2 superoxide"}
{"X":31071,"RHEA_ID":39048,"compounds":"26-oxohexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + hexacosanedioate + oxidized [NADPH--hemoprotein reductase]"}
{"X":31072,"RHEA_ID":29174,"compounds":"a ubiquinol + 2 O2 <=> a ubiquinone + 2 H(+) + 2 superoxide"}
{"X":31073,"RHEA_ID":29175,"compounds":"2 O2 + ubiquinol-8 = 2 H(+) + 2 superoxide + ubiquinone-8"}
{"X":31074,"RHEA_ID":29176,"compounds":"2 O2 + ubiquinol-8 => 2 H(+) + 2 superoxide + ubiquinone-8"}
{"X":31075,"RHEA_ID":39052,"compounds":"ATP + cholesterol(in) + H2O => ADP + cholesterol(out) + H(+) + phosphate"}
{"X":31076,"RHEA_ID":29178,"compounds":"2 O2 + ubiquinol-8 <=> 2 H(+) + 2 superoxide + ubiquinone-8"}
{"X":31077,"RHEA_ID":29179,"compounds":"a menaquinol + 2 O2 = a menaquinone + 2 H(+) + 2 superoxide"}
{"X":31078,"RHEA_ID":29180,"compounds":"a menaquinol + 2 O2 => a menaquinone + 2 H(+) + 2 superoxide"}
{"X":31079,"RHEA_ID":39056,"compounds":"22-hydroxydocosanoate + O2 + reduced [NADPH--hemoprotein reductase] => 22-oxodocosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":31080,"RHEA_ID":29182,"compounds":"a menaquinol + 2 O2 <=> a menaquinone + 2 H(+) + 2 superoxide"}
{"X":31081,"RHEA_ID":29183,"compounds":"menaquinol-8 + 2 O2 = 2 H(+) + menaquinone-8 + 2 superoxide"}
{"X":31082,"RHEA_ID":29184,"compounds":"menaquinol-8 + 2 O2 => 2 H(+) + menaquinone-8 + 2 superoxide"}
{"X":31083,"RHEA_ID":29185,"compounds":"2 H(+) + menaquinone-8 + 2 superoxide => menaquinol-8 + 2 O2"}
{"X":31084,"RHEA_ID":29186,"compounds":"menaquinol-8 + 2 O2 <=> 2 H(+) + menaquinone-8 + 2 superoxide"}
{"X":31085,"RHEA_ID":29187,"compounds":"succinate + ubiquinone-8 = fumarate + ubiquinol-8"}
{"X":31086,"RHEA_ID":29188,"compounds":"succinate + ubiquinone-8 => fumarate + ubiquinol-8"}
{"X":31087,"RHEA_ID":39064,"compounds":"NADP(+) + scyllo-inositol => H(+) + NADPH + scyllo-inosose"}
{"X":31088,"RHEA_ID":29190,"compounds":"succinate + ubiquinone-8 <=> fumarate + ubiquinol-8"}
{"X":31089,"RHEA_ID":29191,"compounds":"L-aspartate + menaquinone-8 = iminosuccinate + menaquinol-8"}
{"X":31090,"RHEA_ID":29192,"compounds":"L-aspartate + menaquinone-8 => iminosuccinate + menaquinol-8"}
{"X":31091,"RHEA_ID":29193,"compounds":"iminosuccinate + menaquinol-8 => L-aspartate + menaquinone-8"}
{"X":31092,"RHEA_ID":39069,"compounds":"acetyl-CoA + hexanedioyl-CoA => 3-oxooctanedioyl-CoA + CoA"}
{"X":31093,"RHEA_ID":29195,"compounds":"(S)-dihydroorotate + a menaquinone = a menaquinol + orotate"}
{"X":31094,"RHEA_ID":29196,"compounds":"(S)-dihydroorotate + a menaquinone => a menaquinol + orotate"}
{"X":31095,"RHEA_ID":29197,"compounds":"a menaquinol + orotate => (S)-dihydroorotate + a menaquinone"}
{"X":31096,"RHEA_ID":39073,"compounds":"(2E)-dodecenedioyl-CoA + H2O2 => dodecanedioyl-CoA + O2"}
{"X":31097,"RHEA_ID":29199,"compounds":"(S)-dihydroorotate + menaquinone-8 = menaquinol-8 + orotate"}
{"X":31098,"RHEA_ID":29200,"compounds":"(S)-dihydroorotate + menaquinone-8 => menaquinol-8 + orotate"}
{"X":31099,"RHEA_ID":29201,"compounds":"menaquinol-8 + orotate => (S)-dihydroorotate + menaquinone-8"}
{"X":31100,"RHEA_ID":39077,"compounds":"(3S)-hydroxydodecanedioyl-CoA => (2E)-dodecenedioyl-CoA + H2O"}
{"X":31101,"RHEA_ID":29203,"compounds":"dimethyl sulfoxide + menaquinol-8 = dimethyl sulfide + H2O + menaquinone-8"}
{"X":31102,"RHEA_ID":29204,"compounds":"dimethyl sulfoxide + menaquinol-8 => dimethyl sulfide + H2O + menaquinone-8"}
{"X":31103,"RHEA_ID":29205,"compounds":"dimethyl sulfide + H2O + menaquinone-8 => dimethyl sulfoxide + menaquinol-8"}
{"X":31104,"RHEA_ID":39081,"compounds":"3-oxododecanedioyl-CoA + H(+) + NADH => (3S)-hydroxydodecanedioyl-CoA + NAD(+)"}
{"X":31105,"RHEA_ID":29207,"compounds":"a menaquinol(in) + dimethyl sulfoxide(out) = a menaquinone(in) + dimethyl sulfide(out) + H2O(out)"}
{"X":31106,"RHEA_ID":29208,"DIRECTION":"LR","MASTER_ID":29207,"ecocyc":"DIMESULFREDUCT-RXN","metacyc":"DIMESULFREDUCT-RXN","compounds":"a menaquinol(in) + dimethyl sulfoxide(out) => a menaquinone(in) + dimethyl sulfide(out) + H2O(out)"}
{"X":31107,"RHEA_ID":29209,"compounds":"a menaquinone(in) + dimethyl sulfide(out) + H2O(out) => a menaquinol(in) + dimethyl sulfoxide(out)"}
{"X":31108,"RHEA_ID":39085,"compounds":"acetyl-CoA + decanedioyl-CoA => 3-oxododecanedioyl-CoA + CoA"}
{"X":31109,"RHEA_ID":29211,"compounds":"H(+)(out) + inosine(in) = H(+)(in) + inosine(out)"}
{"X":31110,"RHEA_ID":29212,"DIRECTION":"LR","MASTER_ID":29211,"ecocyc":"RXN0-18","compounds":"H(+)(out) + inosine(in) => H(+)(in) + inosine(out)"}
{"X":31111,"RHEA_ID":29213,"compounds":"H(+)(in) + inosine(out) => H(+)(out) + inosine(in)"}
{"X":31112,"RHEA_ID":29214,"compounds":"H(+)(out) + inosine(in) <=> H(+)(in) + inosine(out)"}
{"X":31113,"RHEA_ID":29215,"compounds":"fumarate + menaquinol-8 = menaquinone-8 + succinate"}
{"X":31114,"RHEA_ID":29216,"DIRECTION":"LR","MASTER_ID":29215,"ecocyc":"R601-RXN","metacyc":"R601-RXN","compounds":"fumarate + menaquinol-8 => menaquinone-8 + succinate"}
{"X":31115,"RHEA_ID":29217,"compounds":"menaquinone-8 + succinate => fumarate + menaquinol-8"}
{"X":31116,"RHEA_ID":29218,"compounds":"fumarate + menaquinol-8 <=> menaquinone-8 + succinate"}
{"X":31117,"RHEA_ID":29219,"DIRECTION":"UN","MASTER_ID":29219,"ec":"1.1.5.3","compounds":"a menaquinone + sn-glycerol 3-phosphate = a menaquinol + dihydroxyacetone phosphate"}
{"X":31118,"RHEA_ID":29220,"DIRECTION":"LR","MASTER_ID":29219,"ecocyc":"RXN-15740","metacyc":"RXN-15740","compounds":"a menaquinone + sn-glycerol 3-phosphate => a menaquinol + dihydroxyacetone phosphate"}
{"X":31119,"RHEA_ID":29221,"compounds":"a menaquinol + dihydroxyacetone phosphate => a menaquinone + sn-glycerol 3-phosphate"}
{"X":31120,"RHEA_ID":29222,"compounds":"a menaquinone + sn-glycerol 3-phosphate <=> a menaquinol + dihydroxyacetone phosphate"}
{"X":31121,"RHEA_ID":29223,"compounds":"menaquinone-8 + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + menaquinol-8"}
{"X":31122,"RHEA_ID":29224,"compounds":"menaquinone-8 + sn-glycerol 3-phosphate => dihydroxyacetone phosphate + menaquinol-8"}
{"X":31123,"RHEA_ID":29225,"compounds":"dihydroxyacetone phosphate + menaquinol-8 => menaquinone-8 + sn-glycerol 3-phosphate"}
{"X":31124,"RHEA_ID":39101,"compounds":"acetyl-CoA + octanedioyl-CoA => 3-oxodecanedioyl-CoA + CoA"}
{"X":31125,"RHEA_ID":29227,"compounds":"H(+)(in) + indole(in) = H(+)(out) + indole(out)"}
{"X":31126,"RHEA_ID":29228,"compounds":"H(+)(in) + indole(in) => H(+)(out) + indole(out)"}
{"X":31127,"RHEA_ID":29229,"DIRECTION":"RL","MASTER_ID":29227,"ecocyc":"TRANS-RXN-142","compounds":"H(+)(out) + indole(out) => H(+)(in) + indole(in)"}
{"X":31128,"RHEA_ID":29230,"compounds":"H(+)(in) + indole(in) <=> H(+)(out) + indole(out)"}
{"X":31129,"RHEA_ID":29231,"compounds":"cyanate(in) + H(+)(in) = cyanate(out) + H(+)(out)"}
{"X":31130,"RHEA_ID":29232,"compounds":"cyanate(in) + H(+)(in) => cyanate(out) + H(+)(out)"}
{"X":31131,"RHEA_ID":29233,"DIRECTION":"RL","MASTER_ID":29231,"ecocyc":"TRANS-RXN-14","compounds":"cyanate(out) + H(+)(out) => cyanate(in) + H(+)(in)"}
{"X":31132,"RHEA_ID":39109,"compounds":"(5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O => (5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate"}
{"X":31133,"RHEA_ID":29235,"compounds":"a menaquinone + H(+) + NADH = a menaquinol + NAD(+)"}
{"X":31134,"RHEA_ID":29236,"compounds":"a menaquinone + H(+) + NADH => a menaquinol + NAD(+)"}
{"X":31135,"RHEA_ID":29237,"compounds":"a menaquinol + NAD(+) => a menaquinone + H(+) + NADH"}
{"X":31136,"RHEA_ID":29238,"compounds":"a menaquinone + H(+) + NADH <=> a menaquinol + NAD(+)"}
{"X":31137,"RHEA_ID":29239,"compounds":"H(+)(in) + uracil(in) = H(+)(out) + uracil(out)"}
{"X":31138,"RHEA_ID":29240,"compounds":"H(+)(in) + uracil(in) => H(+)(out) + uracil(out)"}
{"X":31139,"RHEA_ID":29241,"DIRECTION":"RL","MASTER_ID":29239,"ecocyc":"TRANS-RXN-132","compounds":"H(+)(out) + uracil(out) => H(+)(in) + uracil(in)"}
{"X":31140,"RHEA_ID":29242,"compounds":"H(+)(in) + uracil(in) <=> H(+)(out) + uracil(out)"}
{"X":31141,"RHEA_ID":29243,"compounds":"H(+) + menaquinone-8 + NADH = menaquinol-8 + NAD(+)"}
{"X":31142,"RHEA_ID":39119,"compounds":"(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + O2 = (2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O2"}
{"X":31143,"RHEA_ID":29245,"compounds":"menaquinol-8 + NAD(+) => H(+) + menaquinone-8 + NADH"}
{"X":31144,"RHEA_ID":29246,"compounds":"H(+) + menaquinone-8 + NADH <=> menaquinol-8 + NAD(+)"}
{"X":31145,"RHEA_ID":29247,"compounds":"3 H(+)(out) + 2 Na(+)(in) = 3 H(+)(in) + 2 Na(+)(out)"}
{"X":31146,"RHEA_ID":39123,"compounds":"(2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O = (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA"}
{"X":31147,"RHEA_ID":29249,"compounds":"3 H(+)(in) + 2 Na(+)(out) => 3 H(+)(out) + 2 Na(+)(in)"}
{"X":31148,"RHEA_ID":29250,"compounds":"3 H(+)(out) + 2 Na(+)(in) <=> 3 H(+)(in) + 2 Na(+)(out)"}
{"X":31149,"RHEA_ID":29251,"compounds":"2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out)"}
{"X":31150,"RHEA_ID":39127,"compounds":"(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + NAD(+) = 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADH"}
{"X":31151,"RHEA_ID":29253,"DIRECTION":"RL","MASTER_ID":29251,"ecocyc":"TRANS-RXN-129","compounds":"2 H(+)(in) + Na(+)(out) => 2 H(+)(out) + Na(+)(in)"}
{"X":31152,"RHEA_ID":29254,"compounds":"2 H(+)(out) + Na(+)(in) <=> 2 H(+)(in) + Na(+)(out)"}
{"X":31153,"RHEA_ID":29255,"compounds":"Ca(2+)(in) + Na(+)(out) = Ca(2+)(out) + Na(+)(in)"}
{"X":31154,"RHEA_ID":39131,"compounds":"3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CoA = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + acetyl-CoA"}
{"X":31155,"RHEA_ID":29257,"compounds":"Ca(2+)(out) + Na(+)(in) => Ca(2+)(in) + Na(+)(out)"}
{"X":31156,"RHEA_ID":29258,"compounds":"Ca(2+)(in) + Na(+)(out) <=> Ca(2+)(out) + Na(+)(in)"}
{"X":31157,"RHEA_ID":29259,"compounds":"(2R,3R)-tartrate(out) + succinate(in) = (2R,3R)-tartrate(in) + succinate(out)"}
{"X":31158,"RHEA_ID":39135,"compounds":"(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + O2 = (2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O2"}
{"X":31159,"RHEA_ID":29261,"compounds":"(2R,3R)-tartrate(in) + succinate(out) => (2R,3R)-tartrate(out) + succinate(in)"}
{"X":31160,"RHEA_ID":29262,"compounds":"(2R,3R)-tartrate(out) + succinate(in) <=> (2R,3R)-tartrate(in) + succinate(out)"}
{"X":31161,"RHEA_ID":29263,"compounds":"L-leucine(in) + Na(+)(in) = L-leucine(out) + Na(+)(out)"}
{"X":31162,"RHEA_ID":39139,"compounds":"(2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O = (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA"}
{"X":31163,"RHEA_ID":29264,"DIRECTION":"LR","MASTER_ID":29263,"reactome":"R-HSA-375473.1","compounds":"L-leucine(in) + Na(+)(in) => L-leucine(out) + Na(+)(out)"}
{"X":31164,"RHEA_ID":29264,"DIRECTION":"LR","MASTER_ID":29263,"reactome":"R-HSA-352108.1","compounds":"L-leucine(in) + Na(+)(in) => L-leucine(out) + Na(+)(out)"}
{"X":31165,"RHEA_ID":29265,"DIRECTION":"RL","MASTER_ID":29263,"ecocyc":"TRANS-RXN-126B","compounds":"L-leucine(out) + Na(+)(out) => L-leucine(in) + Na(+)(in)"}
{"X":31166,"RHEA_ID":29266,"compounds":"L-leucine(in) + Na(+)(in) <=> L-leucine(out) + Na(+)(out)"}
{"X":31167,"RHEA_ID":29267,"compounds":"L-valine(in) + Na(+)(in) = L-valine(out) + Na(+)(out)"}
{"X":31168,"RHEA_ID":29268,"DIRECTION":"LR","MASTER_ID":29267,"reactome":"R-HSA-352059.1","compounds":"L-valine(in) + Na(+)(in) => L-valine(out) + Na(+)(out)"}
{"X":31169,"RHEA_ID":29268,"DIRECTION":"LR","MASTER_ID":29267,"reactome":"R-HSA-375473.1","compounds":"L-valine(in) + Na(+)(in) => L-valine(out) + Na(+)(out)"}
{"X":31170,"RHEA_ID":29269,"DIRECTION":"RL","MASTER_ID":29267,"ecocyc":"TRANS-RXN-126A","compounds":"L-valine(out) + Na(+)(out) => L-valine(in) + Na(+)(in)"}
{"X":31171,"RHEA_ID":29270,"compounds":"L-valine(in) + Na(+)(in) <=> L-valine(out) + Na(+)(out)"}
{"X":31172,"RHEA_ID":29271,"compounds":"a menaquinol + H(+) + trimethylamine N-oxide = a menaquinone + H2O + trimethylamine"}
{"X":31173,"RHEA_ID":29272,"DIRECTION":"LR","MASTER_ID":29271,"ecocyc":"RXN0-5264","metacyc":"RXN0-5264","compounds":"a menaquinol + H(+) + trimethylamine N-oxide => a menaquinone + H2O + trimethylamine"}
{"X":31174,"RHEA_ID":39151,"compounds":"3-oxooctadecanoyl-CoA + H(+) + NADPH = (3R)-hydroxyoctadecanoyl-CoA + NADP(+)"}
{"X":31175,"RHEA_ID":29274,"compounds":"a menaquinol + H(+) + trimethylamine N-oxide <=> a menaquinone + H2O + trimethylamine"}
{"X":31176,"RHEA_ID":29275,"compounds":"L-isoleucine(in) + Na(+)(in) = L-isoleucine(out) + Na(+)(out)"}
{"X":31177,"RHEA_ID":29276,"DIRECTION":"LR","MASTER_ID":29275,"reactome":"R-HSA-375473.1","compounds":"L-isoleucine(in) + Na(+)(in) => L-isoleucine(out) + Na(+)(out)"}
{"X":31178,"RHEA_ID":39155,"compounds":"(3R)-hydroxyoctadecanoyl-CoA = (2E)-octadecenoyl-CoA + H2O"}
{"X":31179,"RHEA_ID":29278,"compounds":"L-isoleucine(in) + Na(+)(in) <=> L-isoleucine(out) + Na(+)(out)"}
{"X":31180,"RHEA_ID":29279,"compounds":"H(+) + menaquinol-8 + trimethylamine N-oxide = H2O + menaquinone-8 + trimethylamine"}
{"X":31181,"RHEA_ID":29280,"DIRECTION":"LR","MASTER_ID":29279,"ecocyc":"RXN0-5264","metacyc":"RXN0-5264","compounds":"H(+) + menaquinol-8 + trimethylamine N-oxide => H2O + menaquinone-8 + trimethylamine"}
{"X":31182,"RHEA_ID":29281,"compounds":"H2O + menaquinone-8 + trimethylamine => H(+) + menaquinol-8 + trimethylamine N-oxide"}
{"X":31183,"RHEA_ID":29282,"compounds":"H(+) + menaquinol-8 + trimethylamine N-oxide <=> H2O + menaquinone-8 + trimethylamine"}
{"X":31184,"RHEA_ID":29283,"compounds":"L-alanine(in) + Na(+)(in) = L-alanine(out) + Na(+)(out)"}
{"X":31185,"RHEA_ID":29284,"DIRECTION":"LR","MASTER_ID":29283,"reactome":"R-HSA-352059.1","compounds":"L-alanine(in) + Na(+)(in) => L-alanine(out) + Na(+)(out)"}
{"X":31186,"RHEA_ID":29284,"DIRECTION":"LR","MASTER_ID":29283,"reactome":"R-HSA-352108.1","compounds":"L-alanine(in) + Na(+)(in) => L-alanine(out) + Na(+)(out)"}
{"X":31187,"RHEA_ID":29284,"DIRECTION":"LR","MASTER_ID":29283,"reactome":"R-HSA-375473.1","compounds":"L-alanine(in) + Na(+)(in) => L-alanine(out) + Na(+)(out)"}
{"X":31188,"RHEA_ID":29285,"DIRECTION":"RL","MASTER_ID":29283,"ecocyc":"TRANS-RXN-125","compounds":"L-alanine(out) + Na(+)(out) => L-alanine(in) + Na(+)(in)"}
{"X":31189,"RHEA_ID":29286,"compounds":"L-alanine(in) + Na(+)(in) <=> L-alanine(out) + Na(+)(out)"}
{"X":31190,"RHEA_ID":29287,"compounds":"2 H(+)(in) + L-aspartate(in) = 2 H(+)(out) + L-aspartate(out)"}
{"X":31191,"RHEA_ID":29288,"compounds":"2 H(+)(in) + L-aspartate(in) => 2 H(+)(out) + L-aspartate(out)"}
{"X":31192,"RHEA_ID":29289,"DIRECTION":"RL","MASTER_ID":29287,"ecocyc":"TRANS-RXN-122A","metacyc":"TRANS-RXN-122A","compounds":"2 H(+)(out) + L-aspartate(out) => 2 H(+)(in) + L-aspartate(in)"}
{"X":31193,"RHEA_ID":29290,"compounds":"2 H(+)(in) + L-aspartate(in) <=> 2 H(+)(out) + L-aspartate(out)"}
{"X":31194,"RHEA_ID":29291,"DIRECTION":"UN","MASTER_ID":29291,"ec":"6.2.1.42","compounds":"(25S)-3-oxocholest-4-en-26-oate + ATP + CoA = (25S)-3-oxocholest-4-en-26-oyl-CoA + AMP + diphosphate"}
{"X":31195,"RHEA_ID":29292,"DIRECTION":"LR","MASTER_ID":29291,"metacyc":"RXN-12702","compounds":"(25S)-3-oxocholest-4-en-26-oate + ATP + CoA => (25S)-3-oxocholest-4-en-26-oyl-CoA + AMP + diphosphate"}
{"X":31196,"RHEA_ID":29293,"compounds":"(25S)-3-oxocholest-4-en-26-oyl-CoA + AMP + diphosphate => (25S)-3-oxocholest-4-en-26-oate + ATP + CoA"}
{"X":31197,"RHEA_ID":49072,"DIRECTION":"UN","MASTER_ID":49072,"ec":"1.14.14.21","metacyc":"RXN-17496","compounds":"dibenzothiophene + 2 FMNH2 + 2 O2 = dibenzothiophene 5,5-dioxide + 2 FMN + 2 H(+) + 2 H2O"}
{"X":31198,"RHEA_ID":29295,"compounds":"aldehydo-D-galacturonate(out) + H(+)(out) = aldehydo-D-galacturonate(in) + H(+)(in)"}
{"X":31199,"RHEA_ID":29296,"compounds":"aldehydo-D-galacturonate(out) + H(+)(out) => aldehydo-D-galacturonate(in) + H(+)(in)"}
{"X":31200,"RHEA_ID":29297,"DIRECTION":"RL","MASTER_ID":29295,"ecocyc":"TRANS-RXN-123","compounds":"aldehydo-D-galacturonate(in) + H(+)(in) => aldehydo-D-galacturonate(out) + H(+)(out)"}
{"X":31201,"RHEA_ID":39178,"compounds":"(3R)-hydroxyeicosanoyl-CoA <=> (2E)-eicosenoyl-CoA + H2O"}
{"X":31202,"RHEA_ID":29303,"compounds":"2 H(+)(in) + succinate(in) = 2 H(+)(out) + succinate(out)"}
{"X":31203,"RHEA_ID":29304,"compounds":"2 H(+)(in) + succinate(in) => 2 H(+)(out) + succinate(out)"}
{"X":31204,"RHEA_ID":29305,"DIRECTION":"RL","MASTER_ID":29303,"ecocyc":"TRANS-RXN-121","compounds":"2 H(+)(out) + succinate(out) => 2 H(+)(in) + succinate(in)"}
{"X":31205,"RHEA_ID":39182,"compounds":"(2E)-eicosenoyl-CoA + H(+) + NADPH <=> eicosanoyl-CoA + NADP(+)"}
{"X":31206,"RHEA_ID":29307,"DIRECTION":"UN","MASTER_ID":29307,"ec":"1.14.14.34","compounds":"FMNH2 + methanesulfonate + O2 = FMN + formaldehyde + 2 H(+) + H2O + sulfite"}
{"X":31207,"RHEA_ID":29308,"DIRECTION":"LR","MASTER_ID":29307,"metacyc":"RXN-18086","compounds":"FMNH2 + methanesulfonate + O2 => FMN + formaldehyde + 2 H(+) + H2O + sulfite"}
{"X":31208,"RHEA_ID":29309,"compounds":"FMN + formaldehyde + 2 H(+) + H2O + sulfite => FMNH2 + methanesulfonate + O2"}
{"X":31209,"RHEA_ID":49084,"DIRECTION":"UN","MASTER_ID":49084,"ec":"1.14.19.72","compounds":"(-)-matairesinol + O2 + reduced [NADPH--hemoprotein reductase] = (-)-pluviatolide + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":31210,"RHEA_ID":29311,"compounds":"FMNH2 + O2 + sulfoacetate = FMN + glyoxylate + 2 H(+) + H2O + sulfite"}
{"X":31211,"RHEA_ID":29312,"compounds":"FMNH2 + O2 + sulfoacetate => FMN + glyoxylate + 2 H(+) + H2O + sulfite"}
{"X":31212,"RHEA_ID":29313,"compounds":"FMN + glyoxylate + 2 H(+) + H2O + sulfite => FMNH2 + O2 + sulfoacetate"}
{"X":31213,"RHEA_ID":39190,"compounds":"(3R)-hydroxydocosanoyl-CoA <=> (2E)-docosenoyl-CoA + H2O"}
{"X":31214,"RHEA_ID":29315,"DIRECTION":"UN","MASTER_ID":29315,"ec":"3.1.3.94","compounds":"alpha-D-galactose 1-phosphate + H2O = D-galactose + phosphate"}
{"X":31215,"RHEA_ID":29316,"DIRECTION":"LR","MASTER_ID":29315,"metacyc":"RXN-14938","compounds":"alpha-D-galactose 1-phosphate + H2O => D-galactose + phosphate"}
{"X":31216,"RHEA_ID":29317,"compounds":"D-galactose + phosphate => alpha-D-galactose 1-phosphate + H2O"}
{"X":31217,"RHEA_ID":49092,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphate + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphate"}
{"X":31218,"RHEA_ID":29319,"compounds":"H2O + sn-glycero-3-phosphoethanolamine = ethanolamine + H(+) + sn-glycerol 3-phosphate"}
{"X":31219,"RHEA_ID":29320,"DIRECTION":"LR","MASTER_ID":29319,"ecocyc":"RXN-14160","metacyc":"RXN-14160","compounds":"H2O + sn-glycero-3-phosphoethanolamine => ethanolamine + H(+) + sn-glycerol 3-phosphate"}
{"X":31220,"RHEA_ID":29321,"compounds":"ethanolamine + H(+) + sn-glycerol 3-phosphate => H2O + sn-glycero-3-phosphoethanolamine"}
{"X":31221,"RHEA_ID":39198,"compounds":"3-oxotetracosanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxytetracosanoyl-CoA + NADP(+)"}
{"X":31222,"RHEA_ID":29323,"compounds":"fumarate(in) + succinate(out) = fumarate(out) + succinate(in)"}
{"X":31223,"RHEA_ID":29324,"compounds":"fumarate(in) + succinate(out) => fumarate(out) + succinate(in)"}
{"X":31224,"RHEA_ID":29325,"DIRECTION":"RL","MASTER_ID":29323,"ecocyc":"TRANS-RXN-106","compounds":"fumarate(out) + succinate(in) => fumarate(in) + succinate(out)"}
{"X":31225,"RHEA_ID":29326,"compounds":"fumarate(in) + succinate(out) <=> fumarate(out) + succinate(in)"}
{"X":31226,"RHEA_ID":29327,"compounds":"(S)-malate(in) + succinate(out) = (S)-malate(out) + succinate(in)"}
{"X":31227,"RHEA_ID":29328,"compounds":"(S)-malate(in) + succinate(out) => (S)-malate(out) + succinate(in)"}
{"X":31228,"RHEA_ID":29329,"DIRECTION":"RL","MASTER_ID":29327,"ecocyc":"TRANS-RXN-106B","compounds":"(S)-malate(out) + succinate(in) => (S)-malate(in) + succinate(out)"}
{"X":31229,"RHEA_ID":39206,"compounds":"(2E)-tetracosenoyl-CoA + H(+) + NADPH <=> NADP(+) + tetracosanoyl-CoA"}
{"X":31230,"RHEA_ID":29331,"compounds":"fumarate(in) + 2 H(+)(in) = fumarate(out) + 2 H(+)(out)"}
{"X":31231,"RHEA_ID":29332,"compounds":"fumarate(in) + 2 H(+)(in) => fumarate(out) + 2 H(+)(out)"}
{"X":31232,"RHEA_ID":29333,"DIRECTION":"RL","MASTER_ID":29331,"ecocyc":"TRANS-RXN-121B","compounds":"fumarate(out) + 2 H(+)(out) => fumarate(in) + 2 H(+)(in)"}
{"X":31233,"RHEA_ID":39210,"compounds":"3-oxohexacosanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxyhexacosanoyl-CoA + NADP(+)"}
{"X":31234,"RHEA_ID":29335,"compounds":"H2O + L-alanyl-L-glutamate = L-alanine + L-glutamate"}
{"X":31235,"RHEA_ID":29336,"DIRECTION":"LR","MASTER_ID":29335,"metacyc":"RXN0-6981","compounds":"H2O + L-alanyl-L-glutamate => L-alanine + L-glutamate"}
{"X":31236,"RHEA_ID":29337,"compounds":"L-alanine + L-glutamate => H2O + L-alanyl-L-glutamate"}
{"X":31237,"RHEA_ID":29338,"compounds":"H2O + L-alanyl-L-glutamate <=> L-alanine + L-glutamate"}
{"X":31238,"RHEA_ID":29339,"compounds":"(S)-malate(in) + 2 H(+)(in) = (S)-malate(out) + 2 H(+)(out)"}
{"X":31239,"RHEA_ID":29340,"compounds":"(S)-malate(in) + 2 H(+)(in) => (S)-malate(out) + 2 H(+)(out)"}
{"X":31240,"RHEA_ID":29341,"DIRECTION":"RL","MASTER_ID":29339,"ecocyc":"TRANS-RXN-121A","compounds":"(S)-malate(out) + 2 H(+)(out) => (S)-malate(in) + 2 H(+)(in)"}
{"X":31241,"RHEA_ID":29342,"compounds":"(S)-malate(in) + 2 H(+)(in) <=> (S)-malate(out) + 2 H(+)(out)"}
{"X":31242,"RHEA_ID":29343,"compounds":"L-aspartate(in) + succinate(out) = L-aspartate(out) + succinate(in)"}
{"X":31243,"RHEA_ID":29344,"compounds":"L-aspartate(in) + succinate(out) => L-aspartate(out) + succinate(in)"}
{"X":31244,"RHEA_ID":29345,"DIRECTION":"RL","MASTER_ID":29343,"ecocyc":"TRANS-RXN-106A","metacyc":"TRANS-RXN-106A","compounds":"L-aspartate(out) + succinate(in) => L-aspartate(in) + succinate(out)"}
{"X":31245,"RHEA_ID":39222,"compounds":"3-oxooctacosanyol-CoA + H(+) + NADPH <=> (3R)-hydroxyoctacosanoyl-CoA + NADP(+)"}
{"X":31246,"RHEA_ID":29347,"compounds":"2 H(+)(in) + orotate(in) = 2 H(+)(out) + orotate(out)"}
{"X":31247,"RHEA_ID":29348,"compounds":"2 H(+)(in) + orotate(in) => 2 H(+)(out) + orotate(out)"}
{"X":31248,"RHEA_ID":29349,"DIRECTION":"RL","MASTER_ID":29347,"ecocyc":"TRANS-RXN-121C","compounds":"2 H(+)(out) + orotate(out) => 2 H(+)(in) + orotate(in)"}
{"X":31249,"RHEA_ID":29350,"compounds":"2 H(+)(in) + orotate(in) <=> 2 H(+)(out) + orotate(out)"}
{"X":31250,"RHEA_ID":29351,"compounds":"Zn(2+)(in) = Zn(2+)(out)"}
{"X":31251,"RHEA_ID":29352,"DIRECTION":"LR","MASTER_ID":29351,"reactome":"R-HSA-442405.1","compounds":"Zn(2+)(in) => Zn(2+)(out)"}
{"X":31252,"RHEA_ID":29352,"DIRECTION":"LR","MASTER_ID":29351,"reactome":"R-HSA-442422.1","compounds":"Zn(2+)(in) => Zn(2+)(out)"}
{"X":31253,"RHEA_ID":39230,"compounds":"(2E)-octacosenoyl-CoA + H(+) + NADPH <=> NADP(+) + octacosanoyl-CoA"}
{"X":31254,"RHEA_ID":29352,"DIRECTION":"LR","MASTER_ID":29351,"reactome":"R-HSA-442393.1","compounds":"Zn(2+)(in) => Zn(2+)(out)"}
{"X":31255,"RHEA_ID":29352,"DIRECTION":"LR","MASTER_ID":29351,"reactome":"R-HSA-437084.1","compounds":"Zn(2+)(in) => Zn(2+)(out)"}
{"X":31256,"RHEA_ID":29352,"DIRECTION":"LR","MASTER_ID":29351,"reactome":"R-HSA-442317.1","compounds":"Zn(2+)(in) => Zn(2+)(out)"}
{"X":31257,"RHEA_ID":32573,"compounds":"2-methylisoborneol + diphosphate => (E)-2-methylgeranyl diphosphate + H2O"}
{"X":31258,"RHEA_ID":29353,"DIRECTION":"RL","MASTER_ID":29351,"ecocyc":"RXN0-12","reactome":"R-HSA-437139.1","compounds":"Zn(2+)(out) => Zn(2+)(in)"}
{"X":31259,"RHEA_ID":29353,"DIRECTION":"RL","MASTER_ID":29351,"ecocyc":"RXN0-12","reactome":"R-HSA-437129.1","compounds":"Zn(2+)(out) => Zn(2+)(in)"}
{"X":31260,"RHEA_ID":29353,"DIRECTION":"RL","MASTER_ID":29351,"ecocyc":"RXN0-12","reactome":"R-HSA-437085.1","compounds":"Zn(2+)(out) => Zn(2+)(in)"}
{"X":31261,"RHEA_ID":29353,"DIRECTION":"RL","MASTER_ID":29351,"ecocyc":"RXN0-12","reactome":"R-HSA-437136.1","compounds":"Zn(2+)(out) => Zn(2+)(in)"}
{"X":31262,"RHEA_ID":29353,"DIRECTION":"RL","MASTER_ID":29351,"ecocyc":"RXN0-12","reactome":"R-HSA-435375.1","compounds":"Zn(2+)(out) => Zn(2+)(in)"}
{"X":31263,"RHEA_ID":29353,"DIRECTION":"RL","MASTER_ID":29351,"ecocyc":"RXN0-12","reactome":"R-HSA-435366.1","compounds":"Zn(2+)(out) => Zn(2+)(in)"}
{"X":31264,"RHEA_ID":29354,"compounds":"Zn(2+)(in) <=> Zn(2+)(out)"}
{"X":31265,"RHEA_ID":39242,"compounds":"(2E)-triacontenoyl-CoA + H(+) + NADPH <=> NADP(+) + triacontanoyl-CoA"}
{"X":31266,"RHEA_ID":29356,"DIRECTION":"LR","MASTER_ID":29355,"ecocyc":"RXN-14143","metacyc":"RXN-14143","compounds":"dUMP + H2O => 2'-deoxyuridine + phosphate"}
{"X":31267,"RHEA_ID":29357,"compounds":"2'-deoxyuridine + phosphate => dUMP + H2O"}
{"X":31268,"RHEA_ID":39245,"compounds":"(3R)-hydroxy-(11Z)-eicosenoyl-CoA + NADP(+) => (11Z)-3-oxoicosenoyl-CoA + H(+) + NADPH"}
{"X":31269,"RHEA_ID":39246,"compounds":"(11Z)-3-oxoicosenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(11Z)-eicosenoyl-CoA + NADP(+)"}
{"X":31270,"RHEA_ID":29360,"DIRECTION":"LR","MASTER_ID":29359,"ecocyc":"RXN-14025","metacyc":"RXN-14025","compounds":"H2O + UMP => phosphate + uridine"}
{"X":31271,"RHEA_ID":29361,"compounds":"phosphate + uridine => H2O + UMP"}
{"X":31272,"RHEA_ID":39249,"compounds":"(2E,11Z)-eicosadienoyl-CoA + H2O => (3R)-hydroxy-(11Z)-eicosenoyl-CoA"}
{"X":31273,"RHEA_ID":39250,"compounds":"(3R)-hydroxy-(11Z)-eicosenoyl-CoA <=> (2E,11Z)-eicosadienoyl-CoA + H2O"}
{"X":31274,"RHEA_ID":29364,"DIRECTION":"LR","MASTER_ID":29363,"ecocyc":"RXN0-5292","metacyc":"RXN0-5292","reactome":"R-HSA-109449.4","compounds":"dCMP + H2O => 2'-deoxycytidine + phosphate"}
{"X":31275,"RHEA_ID":29364,"DIRECTION":"LR","MASTER_ID":29363,"ecocyc":"RXN0-5292","metacyc":"RXN0-5292","reactome":"R-HSA-109380.5","compounds":"dCMP + H2O => 2'-deoxycytidine + phosphate"}
{"X":31276,"RHEA_ID":29365,"compounds":"2'-deoxycytidine + phosphate => dCMP + H2O"}
{"X":31277,"RHEA_ID":49152,"compounds":"dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine = dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + H(+) + S-adenosyl-L-homocysteine"}
{"X":31278,"RHEA_ID":29367,"DIRECTION":"UN","MASTER_ID":29367,"ec":"3.1.3.91","compounds":"CMP + H2O = cytidine + phosphate"}
{"X":31279,"RHEA_ID":29368,"DIRECTION":"LR","MASTER_ID":29367,"ecocyc":"RXN-14026","metacyc":"RXN-14026","reactome":"R-HSA-109291.4","compounds":"CMP + H2O => cytidine + phosphate"}
{"X":31280,"RHEA_ID":29369,"compounds":"cytidine + phosphate => CMP + H2O"}
{"X":31281,"RHEA_ID":49156,"compounds":"dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine = dTDP-alpha-D-forosamine + H(+) + S-adenosyl-L-homocysteine"}
{"X":31282,"RHEA_ID":29371,"compounds":"dAMP + H2O = 2'-deoxyadenosine + phosphate"}
{"X":31283,"RHEA_ID":29372,"DIRECTION":"LR","MASTER_ID":29371,"ecocyc":"RXN-14161","metacyc":"RXN-14161","compounds":"dAMP + H2O => 2'-deoxyadenosine + phosphate"}
{"X":31284,"RHEA_ID":29373,"compounds":"2'-deoxyadenosine + phosphate => dAMP + H2O"}
{"X":31285,"RHEA_ID":49160,"compounds":"1,4-cineole + O2 + reduced [NADPH--hemoprotein reductase] = 2-exo-hydroxy-1,4-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":31286,"RHEA_ID":29375,"compounds":"AMP + H2O = adenosine + phosphate"}
{"X":31287,"RHEA_ID":29376,"DIRECTION":"LR","MASTER_ID":29375,"ecocyc":"AMP-DEPHOSPHORYLATION-RXN","metacyc":"AMP-DEPHOSPHORYLATION-RXN","reactome":"R-HSA-109415.3","compounds":"AMP + H2O => adenosine + phosphate"}
{"X":31288,"RHEA_ID":29377,"compounds":"adenosine + phosphate => AMP + H2O"}
{"X":31289,"RHEA_ID":39266,"compounds":"(2E,13Z)-docosadienoyl-CoA + H(+) + NADPH <=> (13Z)-docosenoyl-CoA + NADP(+)"}
{"X":31290,"RHEA_ID":29379,"compounds":"dGMP + H2O = 2'-deoxyguanosine + phosphate"}
{"X":31291,"RHEA_ID":29380,"DIRECTION":"LR","MASTER_ID":29379,"ecocyc":"RXN-14142","metacyc":"RXN-14142","reactome":"R-HSA-109470.4","compounds":"dGMP + H2O => 2'-deoxyguanosine + phosphate"}
{"X":31292,"RHEA_ID":29380,"DIRECTION":"LR","MASTER_ID":29379,"ecocyc":"RXN-14142","metacyc":"RXN-14142","reactome":"R-HSA-74248.4","compounds":"dGMP + H2O => 2'-deoxyguanosine + phosphate"}
{"X":31293,"RHEA_ID":29381,"compounds":"2'-deoxyguanosine + phosphate => dGMP + H2O"}
{"X":31294,"RHEA_ID":39271,"compounds":"(3R)-hydroxy-(15Z)-tetracosenoyl-CoA = (2E,15Z)-tetracosadienoyl-CoA + H2O"}
{"X":31295,"RHEA_ID":29383,"compounds":"dIMP + H2O = 2'-deoxyinosine + phosphate"}
{"X":31296,"RHEA_ID":29384,"compounds":"dIMP + H2O => 2'-deoxyinosine + phosphate"}
{"X":31297,"RHEA_ID":39274,"compounds":"(3R)-hydroxy-(15Z)-tetracosenoyl-CoA <=> (2E,15Z)-tetracosadienoyl-CoA + H2O"}
{"X":31298,"RHEA_ID":29386,"compounds":"dIMP + H2O <=> 2'-deoxyinosine + phosphate"}
{"X":31299,"RHEA_ID":29387,"compounds":"CTP + H2O = CDP + H(+) + phosphate"}
{"X":31300,"RHEA_ID":29388,"compounds":"CTP + H2O => CDP + H(+) + phosphate"}
{"X":31301,"RHEA_ID":29389,"compounds":"CDP + H(+) + phosphate => CTP + H2O"}
{"X":31302,"RHEA_ID":29390,"compounds":"CTP + H2O <=> CDP + H(+) + phosphate"}
{"X":31303,"RHEA_ID":29391,"DIRECTION":"UN","MASTER_ID":29391,"ec":"3.6.1.8","compounds":"GTP + H2O = diphosphate + GMP + H(+)"}
{"X":31304,"RHEA_ID":29391,"DIRECTION":"UN","MASTER_ID":29391,"ec":"3.6.1.9","compounds":"GTP + H2O = diphosphate + GMP + H(+)"}
{"X":31305,"RHEA_ID":29392,"compounds":"GTP + H2O => diphosphate + GMP + H(+)"}
{"X":31306,"RHEA_ID":29393,"compounds":"diphosphate + GMP + H(+) => GTP + H2O"}
{"X":31307,"RHEA_ID":39284,"compounds":"a long-chain fatty acid(out) => a long-chain fatty acid(in)"}
{"X":31308,"RHEA_ID":29395,"DIRECTION":"UN","MASTER_ID":29395,"ec":"3.6.1.9","compounds":"H2O + UTP = diphosphate + H(+) + UMP"}
{"X":31309,"RHEA_ID":39286,"compounds":"a long-chain fatty acid(out) <=> a long-chain fatty acid(in)"}
{"X":31310,"RHEA_ID":29396,"DIRECTION":"LR","MASTER_ID":29395,"ecocyc":"RXN-14139","metacyc":"RXN-14139","compounds":"H2O + UTP => diphosphate + H(+) + UMP"}
{"X":31311,"RHEA_ID":29397,"compounds":"diphosphate + H(+) + UMP => H2O + UTP"}
{"X":31312,"RHEA_ID":39289,"compounds":"[methyl-Co(III) trimethylamine-specific corrinoid protein] + dimethylamine => [Co(I) trimethylamine-specific corrinoid protein] + H(+) + trimethylamine"}
{"X":31313,"RHEA_ID":29399,"DIRECTION":"UN","MASTER_ID":29399,"ec":"3.6.1.8","compounds":"H2O + ITP = diphosphate + H(+) + IMP"}
{"X":31314,"RHEA_ID":29399,"DIRECTION":"UN","MASTER_ID":29399,"ec":"3.6.1.66","compounds":"H2O + ITP = diphosphate + H(+) + IMP"}
{"X":31315,"RHEA_ID":29399,"DIRECTION":"UN","MASTER_ID":29399,"ec":"3.6.1.9","compounds":"H2O + ITP = diphosphate + H(+) + IMP"}
{"X":31316,"RHEA_ID":29400,"DIRECTION":"LR","MASTER_ID":29399,"ecocyc":"RXN0-6382","metacyc":"RXN0-6382","reactome":"R-HSA-2509827.4","compounds":"H2O + ITP => diphosphate + H(+) + IMP"}
{"X":31317,"RHEA_ID":29401,"compounds":"diphosphate + H(+) + IMP => H2O + ITP"}
{"X":31318,"RHEA_ID":39295,"compounds":"(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + AH2 + O2 = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + A + 2 H2O"}
{"X":31319,"RHEA_ID":29403,"compounds":"6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + AH2 + O2 = 3-demethylubiquinol-8 + A + H2O"}
{"X":31320,"RHEA_ID":29404,"DIRECTION":"LR","MASTER_ID":29403,"ecocyc":"OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-RXN","metacyc":"OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-RXN","compounds":"6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + AH2 + O2 => 3-demethylubiquinol-8 + A + H2O"}
{"X":31321,"RHEA_ID":39298,"compounds":"(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + AH2 + O2 <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + A + 2 H2O"}
{"X":31322,"RHEA_ID":29406,"compounds":"6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + AH2 + O2 <=> 3-demethylubiquinol-8 + A + H2O"}
{"X":31323,"RHEA_ID":29407,"compounds":"2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + NADPH + O2 = 2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + H2O + NADP(+)"}
{"X":31324,"RHEA_ID":29408,"DIRECTION":"LR","MASTER_ID":29407,"ecocyc":"2-OCTAPRENYL-6-METHOXYPHENOL-HYDROX-RXN","metacyc":"2-OCTAPRENYL-6-METHOXYPHENOL-HYDROX-RXN","compounds":"2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + NADPH + O2 => 2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + H2O + NADP(+)"}
{"X":31325,"RHEA_ID":29409,"compounds":"2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + H2O + NADP(+) => 2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + NADPH + O2"}
{"X":31326,"RHEA_ID":29410,"compounds":"2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + NADPH + O2 <=> 2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + H2O + NADP(+)"}
{"X":31327,"RHEA_ID":29411,"compounds":"glycolate(in) + H(+)(in) = glycolate(out) + H(+)(out)"}
{"X":31328,"RHEA_ID":29412,"compounds":"glycolate(in) + H(+)(in) => glycolate(out) + H(+)(out)"}
{"X":31329,"RHEA_ID":39306,"compounds":"(3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA <=> (2E,11Z,14Z)-eicosatrienoyl-CoA + H2O"}
{"X":31330,"RHEA_ID":29414,"compounds":"glycolate(in) + H(+)(in) <=> glycolate(out) + H(+)(out)"}
{"X":31331,"RHEA_ID":29415,"compounds":"(S)-lactate(in) + H(+)(in) = (S)-lactate(out) + H(+)(out)"}
{"X":31332,"RHEA_ID":29416,"DIRECTION":"LR","MASTER_ID":29415,"reactome":"R-HSA-373867.3","compounds":"(S)-lactate(in) + H(+)(in) => (S)-lactate(out) + H(+)(out)"}
{"X":31333,"RHEA_ID":39310,"compounds":"(2E,11Z,14Z)-eicosatrienoyl-CoA + H(+) + NADPH <=> (11Z,14Z)-eicosadienoyl-CoA + NADP(+)"}
{"X":31334,"RHEA_ID":29418,"compounds":"(S)-lactate(in) + H(+)(in) <=> (S)-lactate(out) + H(+)(out)"}
{"X":31335,"RHEA_ID":29419,"compounds":"H(+)(out) + Na(+)(in) = H(+)(in) + Na(+)(out)"}
{"X":31336,"RHEA_ID":29420,"DIRECTION":"LR","MASTER_ID":29419,"ecocyc":"TRANS-RXN-101","reactome":"R-HSA-425994.1","compounds":"H(+)(out) + Na(+)(in) => H(+)(in) + Na(+)(out)"}
{"X":31337,"RHEA_ID":29420,"DIRECTION":"LR","MASTER_ID":29419,"ecocyc":"TRANS-RXN-101","reactome":"R-HSA-2872444.1","compounds":"H(+)(out) + Na(+)(in) => H(+)(in) + Na(+)(out)"}
{"X":31338,"RHEA_ID":29421,"DIRECTION":"RL","MASTER_ID":29419,"reactome":"R-HSA-426015.1","compounds":"H(+)(in) + Na(+)(out) => H(+)(out) + Na(+)(in)"}
{"X":31339,"RHEA_ID":29422,"compounds":"H(+)(out) + Na(+)(in) <=> H(+)(in) + Na(+)(out)"}
{"X":31340,"RHEA_ID":29423,"compounds":"ATP + diphosphate = ADP + H(+) + triphosphate"}
{"X":31341,"RHEA_ID":29424,"compounds":"ATP + diphosphate => ADP + H(+) + triphosphate"}
{"X":31342,"RHEA_ID":29425,"compounds":"ADP + H(+) + triphosphate => ATP + diphosphate"}
{"X":31343,"RHEA_ID":29426,"compounds":"ATP + diphosphate <=> ADP + H(+) + triphosphate"}
{"X":31344,"RHEA_ID":29427,"compounds":"(R)-carnitine(out) + 4-(trimethylamino)butanoate(in) = (R)-carnitine(in) + 4-(trimethylamino)butanoate(out)"}
{"X":31345,"RHEA_ID":39322,"compounds":"(2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + NADPH <=> (8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+)"}
{"X":31346,"RHEA_ID":29429,"compounds":"(R)-carnitine(in) + 4-(trimethylamino)butanoate(out) => (R)-carnitine(out) + 4-(trimethylamino)butanoate(in)"}
{"X":31347,"RHEA_ID":29430,"compounds":"(R)-carnitine(out) + 4-(trimethylamino)butanoate(in) <=> (R)-carnitine(in) + 4-(trimethylamino)butanoate(out)"}
{"X":31348,"RHEA_ID":29431,"compounds":"ATP + phosphate = ADP + diphosphate"}
{"X":31349,"RHEA_ID":39326,"compounds":"(7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+)"}
{"X":31350,"RHEA_ID":29433,"compounds":"ADP + diphosphate => ATP + phosphate"}
{"X":31351,"RHEA_ID":29434,"compounds":"ATP + phosphate <=> ADP + diphosphate"}
{"X":31352,"RHEA_ID":29435,"compounds":"enterobactin(in) + H(+)(out) = enterobactin(out) + H(+)(in)"}
{"X":31353,"RHEA_ID":39330,"compounds":"(3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA <=> (2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H2O"}
{"X":31354,"RHEA_ID":29437,"compounds":"enterobactin(out) + H(+)(in) => enterobactin(in) + H(+)(out)"}
{"X":31355,"RHEA_ID":29438,"compounds":"enterobactin(in) + H(+)(out) <=> enterobactin(out) + H(+)(in)"}
{"X":31356,"RHEA_ID":29439,"compounds":"Fe(2+)(in) + H(+)(out) = Fe(2+)(out) + H(+)(in)"}
{"X":31357,"RHEA_ID":39334,"compounds":"(2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H(+) + NADPH <=> (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+)"}
{"X":31358,"RHEA_ID":29441,"compounds":"Fe(2+)(out) + H(+)(in) => Fe(2+)(in) + H(+)(out)"}
{"X":31359,"RHEA_ID":29442,"compounds":"Fe(2+)(in) + H(+)(out) <=> Fe(2+)(out) + H(+)(in)"}
{"X":31360,"RHEA_ID":29443,"compounds":"H(+)(in) + L-alanine(in) = H(+)(out) + L-alanine(out)"}
{"X":31361,"RHEA_ID":29444,"DIRECTION":"LR","MASTER_ID":29443,"reactome":"R-HSA-375417.1","compounds":"H(+)(in) + L-alanine(in) => H(+)(out) + L-alanine(out)"}
{"X":31362,"RHEA_ID":39339,"compounds":"(9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+)"}
{"X":31363,"RHEA_ID":29446,"compounds":"H(+)(in) + L-alanine(in) <=> H(+)(out) + L-alanine(out)"}
{"X":31364,"RHEA_ID":29447,"compounds":"glycolate(in) = glycolate(out)"}
{"X":31365,"RHEA_ID":29448,"compounds":"glycolate(in) => glycolate(out)"}
{"X":31366,"RHEA_ID":39343,"compounds":"(3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA = (2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H2O"}
{"X":31367,"RHEA_ID":29450,"compounds":"glycolate(in) <=> glycolate(out)"}
{"X":31368,"RHEA_ID":29451,"compounds":"H2O + phosphonate = H2 + phosphate"}
{"X":31369,"RHEA_ID":29452,"compounds":"H2O + phosphonate => H2 + phosphate"}
{"X":31370,"RHEA_ID":39347,"compounds":"(2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADPH = (9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+)"}
{"X":31371,"RHEA_ID":29454,"compounds":"H2O + phosphonate <=> H2 + phosphate"}
{"X":31372,"RHEA_ID":29455,"compounds":"D-serine(in) = D-serine(out)"}
{"X":31373,"RHEA_ID":29456,"DIRECTION":"LR","MASTER_ID":29455,"reactome":"R-HSA-376200.1","compounds":"D-serine(in) => D-serine(out)"}
{"X":31374,"RHEA_ID":39351,"compounds":"(3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA = (2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H2O"}
{"X":31375,"RHEA_ID":29458,"compounds":"D-serine(in) <=> D-serine(out)"}
{"X":31376,"RHEA_ID":29459,"compounds":"beta-alanine(in) + H(+)(in) = beta-alanine(out) + H(+)(out)"}
{"X":31377,"RHEA_ID":29460,"compounds":"beta-alanine(in) + H(+)(in) => beta-alanine(out) + H(+)(out)"}
{"X":31378,"RHEA_ID":39355,"compounds":"(2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H(+) + NADPH = (11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+)"}
{"X":31379,"RHEA_ID":29462,"compounds":"beta-alanine(in) + H(+)(in) <=> beta-alanine(out) + H(+)(out)"}
{"X":31380,"RHEA_ID":29463,"compounds":"K(+)(in) = K(+)(out)"}
{"X":31381,"RHEA_ID":29464,"DIRECTION":"LR","MASTER_ID":29463,"reactome":"R-HSA-1296046.2","compounds":"K(+)(in) => K(+)(out)"}
{"X":31382,"RHEA_ID":39359,"compounds":"(13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+)"}
{"X":31383,"RHEA_ID":29465,"DIRECTION":"RL","MASTER_ID":29463,"ecocyc":"TRANS-RXN-143","reactome":"R-HSA-1299318.1","compounds":"K(+)(out) => K(+)(in)"}
{"X":31384,"RHEA_ID":29465,"DIRECTION":"RL","MASTER_ID":29463,"ecocyc":"TRANS-RXN-143","reactome":"R-HSA-1369017.2","compounds":"K(+)(out) => K(+)(in)"}
{"X":31385,"RHEA_ID":29465,"DIRECTION":"RL","MASTER_ID":29463,"ecocyc":"TRANS-RXN-143","reactome":"R-HSA-1299304.1","compounds":"K(+)(out) => K(+)(in)"}
{"X":31386,"RHEA_ID":39363,"compounds":"(3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA = (2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H2O"}
{"X":31387,"RHEA_ID":29465,"DIRECTION":"RL","MASTER_ID":29463,"ecocyc":"TRANS-RXN-143","reactome":"R-HSA-1296039.1","compounds":"K(+)(out) => K(+)(in)"}
{"X":31388,"RHEA_ID":29465,"DIRECTION":"RL","MASTER_ID":29463,"ecocyc":"TRANS-RXN-143","reactome":"R-HSA-1296035.2","compounds":"K(+)(out) => K(+)(in)"}
{"X":31389,"RHEA_ID":29465,"DIRECTION":"RL","MASTER_ID":29463,"ecocyc":"TRANS-RXN-143","reactome":"R-HSA-877187.1","compounds":"K(+)(out) => K(+)(in)"}
{"X":31390,"RHEA_ID":29465,"DIRECTION":"RL","MASTER_ID":29463,"ecocyc":"TRANS-RXN-143","reactome":"R-HSA-1296348.1","compounds":"K(+)(out) => K(+)(in)"}
{"X":31391,"RHEA_ID":29465,"DIRECTION":"RL","MASTER_ID":29463,"ecocyc":"TRANS-RXN-143","reactome":"R-HSA-5577237.4","compounds":"K(+)(out) => K(+)(in)"}
{"X":31392,"RHEA_ID":29465,"DIRECTION":"RL","MASTER_ID":29463,"ecocyc":"TRANS-RXN-143","reactome":"R-HSA-1013020.1","compounds":"K(+)(out) => K(+)(in)"}
{"X":31393,"RHEA_ID":29465,"DIRECTION":"RL","MASTER_ID":29463,"ecocyc":"TRANS-RXN-143","reactome":"R-HSA-1299297.1","compounds":"K(+)(out) => K(+)(in)"}
{"X":31394,"RHEA_ID":39371,"compounds":"3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+)"}
{"X":31395,"RHEA_ID":29465,"DIRECTION":"RL","MASTER_ID":29463,"ecocyc":"TRANS-RXN-143","reactome":"R-HSA-1296024.2","compounds":"K(+)(out) => K(+)(in)"}
{"X":31396,"RHEA_ID":29465,"DIRECTION":"RL","MASTER_ID":29463,"ecocyc":"TRANS-RXN-143","reactome":"R-HSA-5578910.1","compounds":"K(+)(out) => K(+)(in)"}
{"X":31397,"RHEA_ID":29465,"DIRECTION":"RL","MASTER_ID":29463,"ecocyc":"TRANS-RXN-143","reactome":"R-HSA-1299338.1","compounds":"K(+)(out) => K(+)(in)"}
{"X":31398,"RHEA_ID":39375,"compounds":"(3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA = (2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H2O"}
{"X":31399,"RHEA_ID":29465,"DIRECTION":"RL","MASTER_ID":29463,"ecocyc":"TRANS-RXN-143","reactome":"R-HSA-1296127.1","compounds":"K(+)(out) => K(+)(in)"}
{"X":31400,"RHEA_ID":29465,"DIRECTION":"RL","MASTER_ID":29463,"ecocyc":"TRANS-RXN-143","reactome":"R-HSA-1299359.1","compounds":"K(+)(out) => K(+)(in)"}
{"X":31401,"RHEA_ID":29465,"DIRECTION":"RL","MASTER_ID":29463,"ecocyc":"TRANS-RXN-143","reactome":"R-HSA-2534365.1","compounds":"K(+)(out) => K(+)(in)"}
{"X":31402,"RHEA_ID":39379,"compounds":"(2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H(+) + NADPH = (15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+)"}
{"X":31403,"RHEA_ID":29465,"DIRECTION":"RL","MASTER_ID":29463,"ecocyc":"TRANS-RXN-143","reactome":"R-HSA-5577234.1","compounds":"K(+)(out) => K(+)(in)"}
{"X":31404,"RHEA_ID":29465,"DIRECTION":"RL","MASTER_ID":29463,"ecocyc":"TRANS-RXN-143","reactome":"R-HSA-5577050.1","compounds":"K(+)(out) => K(+)(in)"}
{"X":31405,"RHEA_ID":29466,"compounds":"K(+)(in) <=> K(+)(out)"}
{"X":31406,"RHEA_ID":39383,"compounds":"3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+)"}
{"X":31407,"RHEA_ID":29468,"DIRECTION":"LR","MASTER_ID":29467,"ecocyc":"TRANS-RXN-42","compounds":"H(+)(out) + K(+)(in) => H(+)(in) + K(+)(out)"}
{"X":31408,"RHEA_ID":29469,"compounds":"H(+)(in) + K(+)(out) => H(+)(out) + K(+)(in)"}
{"X":31409,"RHEA_ID":29470,"compounds":"H(+)(out) + K(+)(in) <=> H(+)(in) + K(+)(out)"}
{"X":31410,"RHEA_ID":29471,"compounds":"D-ribose 5-phosphate + H2O = D-ribose + phosphate"}
{"X":31411,"RHEA_ID":29472,"compounds":"D-ribose 5-phosphate + H2O => D-ribose + phosphate"}
{"X":31412,"RHEA_ID":29473,"compounds":"D-ribose + phosphate => D-ribose 5-phosphate + H2O"}
{"X":31413,"RHEA_ID":29474,"compounds":"D-ribose 5-phosphate + H2O <=> D-ribose + phosphate"}
{"X":31414,"RHEA_ID":39391,"compounds":"(2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH = (17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+)"}
{"X":31415,"RHEA_ID":29476,"DIRECTION":"LR","MASTER_ID":29475,"metacyc":"RXN-11905","compounds":"(2E,6E)-farnesyl diphosphate => (+)-cubenene + diphosphate"}
{"X":31416,"RHEA_ID":29477,"compounds":"(+)-cubenene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":31417,"RHEA_ID":39394,"compounds":"(2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH <=> (17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+)"}
{"X":31418,"RHEA_ID":29479,"DIRECTION":"UN","MASTER_ID":29479,"ec":"4.2.3.64","compounds":"(2E,6E)-farnesyl diphosphate + H2O = (+)-epicubenol + diphosphate"}
{"X":31419,"RHEA_ID":29480,"DIRECTION":"LR","MASTER_ID":29479,"metacyc":"RXN-11904","compounds":"(2E,6E)-farnesyl diphosphate + H2O => (+)-epicubenol + diphosphate"}
{"X":31420,"RHEA_ID":29481,"compounds":"(+)-epicubenol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}
{"X":31421,"RHEA_ID":39398,"compounds":"3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+)"}
{"X":31422,"RHEA_ID":39399,"compounds":"(3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA = (2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H2O"}
{"X":31423,"RHEA_ID":29483,"DIRECTION":"UN","MASTER_ID":29483,"ec":"4.2.3.66","compounds":"(2E,6E)-farnesyl diphosphate = (+)-beta-selinene + diphosphate"}
{"X":31424,"RHEA_ID":29484,"DIRECTION":"LR","MASTER_ID":29483,"metacyc":"RXN-10685","compounds":"(2E,6E)-farnesyl diphosphate => (+)-beta-selinene + diphosphate"}
{"X":31425,"RHEA_ID":29485,"compounds":"(+)-beta-selinene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":31426,"RHEA_ID":49300,"DIRECTION":"UN","MASTER_ID":49300,"ec":"2.7.1.208","compounds":"D-maltose(out) + N(pros)-phospho-L-histidyl-[protein] = alpha-maltose 6'-phosphate(in) + L-histidyl-[protein]"}
{"X":31427,"RHEA_ID":29487,"DIRECTION":"UN","MASTER_ID":29487,"ec":"4.2.3.67","compounds":"(2E,6E)-farnesyl diphosphate = cis-muurola-3,5-diene + diphosphate"}
{"X":31428,"RHEA_ID":29488,"DIRECTION":"LR","MASTER_ID":29487,"metacyc":"RXN-9962","compounds":"(2E,6E)-farnesyl diphosphate => cis-muurola-3,5-diene + diphosphate"}
{"X":31429,"RHEA_ID":29489,"compounds":"cis-muurola-3,5-diene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":31430,"RHEA_ID":49304,"compounds":"H2O + N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphinganine = a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + N-acetyl-alpha-D-galactosamine"}
{"X":31431,"RHEA_ID":29491,"DIRECTION":"UN","MASTER_ID":29491,"ec":"4.2.3.67","compounds":"(2E,6E)-farnesyl diphosphate = cis-muurola-4(14),5-diene + diphosphate"}
{"X":31432,"RHEA_ID":29492,"DIRECTION":"LR","MASTER_ID":29491,"metacyc":"RXN-9963","compounds":"(2E,6E)-farnesyl diphosphate => cis-muurola-4(14),5-diene + diphosphate"}
{"X":31433,"RHEA_ID":29493,"compounds":"cis-muurola-4(14),5-diene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":31434,"RHEA_ID":49308,"compounds":"a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O = a neolactoside nLc4Cer(d18:0) + L-fucose"}
{"X":31435,"RHEA_ID":29495,"DIRECTION":"UN","MASTER_ID":29495,"ec":"4.2.3.68","compounds":"(2E,6E)-farnesyl diphosphate + H2O = beta-eudesmol + diphosphate"}
{"X":31436,"RHEA_ID":29496,"DIRECTION":"LR","MASTER_ID":29495,"metacyc":"RXN-10636","compounds":"(2E,6E)-farnesyl diphosphate + H2O => beta-eudesmol + diphosphate"}
{"X":31437,"RHEA_ID":29497,"compounds":"beta-eudesmol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}
{"X":31438,"RHEA_ID":49312,"compounds":"2-trans,4-trans-xanthoxin + NAD(+) = 2-trans-(+)-abscisic aldehyde + H(+) + NADH"}
{"X":31439,"RHEA_ID":29499,"DIRECTION":"UN","MASTER_ID":29499,"ec":"4.2.3.69","compounds":"(2E,6E)-farnesyl diphosphate = (+)-alpha-barbatene + diphosphate"}
{"X":31440,"RHEA_ID":29500,"DIRECTION":"LR","MASTER_ID":29499,"metacyc":"RXN-8417","compounds":"(2E,6E)-farnesyl diphosphate => (+)-alpha-barbatene + diphosphate"}
{"X":31441,"RHEA_ID":29501,"compounds":"(+)-alpha-barbatene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":31442,"RHEA_ID":39419,"compounds":"3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+)"}
{"X":31443,"RHEA_ID":29503,"DIRECTION":"UN","MASTER_ID":29503,"ec":"4.2.3.70","compounds":"(2E,6E)-farnesyl diphosphate + H2O = diphosphate + patchoulol"}
{"X":31444,"RHEA_ID":29504,"DIRECTION":"LR","MASTER_ID":29503,"metacyc":"RXN-10600","compounds":"(2E,6E)-farnesyl diphosphate + H2O => diphosphate + patchoulol"}
{"X":31445,"RHEA_ID":29505,"compounds":"diphosphate + patchoulol => (2E,6E)-farnesyl diphosphate + H2O"}
{"X":31446,"RHEA_ID":49320,"compounds":"all-trans-violaxanthin = (5R,6S)-5,6-epoxi-capsanthin"}
{"X":31447,"RHEA_ID":29507,"DIRECTION":"UN","MASTER_ID":29507,"ec":"4.2.3.72","compounds":"(2E,6E)-farnesyl diphosphate = (-)-alpha-gurjunene + diphosphate"}
{"X":31448,"RHEA_ID":29508,"DIRECTION":"LR","MASTER_ID":29507,"metacyc":"RXN-11910","compounds":"(2E,6E)-farnesyl diphosphate => (-)-alpha-gurjunene + diphosphate"}
{"X":31449,"RHEA_ID":29509,"compounds":"(-)-alpha-gurjunene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":31450,"RHEA_ID":39427,"compounds":"(2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH = (23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+)"}
{"X":31451,"RHEA_ID":29511,"DIRECTION":"UN","MASTER_ID":29511,"ec":"4.2.3.73","compounds":"(2E,6E)-farnesyl diphosphate = (+)-valencene + diphosphate"}
{"X":31452,"RHEA_ID":39429,"compounds":"(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+) => (2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH"}
{"X":31453,"RHEA_ID":29513,"compounds":"(+)-valencene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":31454,"RHEA_ID":39431,"compounds":"1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":31455,"RHEA_ID":29515,"DIRECTION":"UN","MASTER_ID":29515,"ec":"2.4.1.132","compounds":"beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)"}
{"X":31456,"RHEA_ID":39433,"compounds":"1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + CoA => 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA"}
{"X":31457,"RHEA_ID":29517,"compounds":"alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+) => beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose"}
{"X":31458,"RHEA_ID":39435,"compounds":"(11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+)"}
{"X":31459,"RHEA_ID":29519,"DIRECTION":"UN","MASTER_ID":29519,"ec":"2.4.1.257","compounds":"alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)"}
{"X":31460,"RHEA_ID":29520,"DIRECTION":"LR","MASTER_ID":29519,"metacyc":"RXN-5463","compounds":"alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose => alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)"}
{"X":31461,"RHEA_ID":29521,"compounds":"alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+) => alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose"}
{"X":31462,"RHEA_ID":39441,"compounds":"(2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H2O => (3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA"}
{"X":31463,"RHEA_ID":29524,"DIRECTION":"LR","MASTER_ID":29523,"metacyc":"RXN-5464","compounds":"alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H(+)"}
{"X":31464,"RHEA_ID":29525,"compounds":"alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H(+) => alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose"}
{"X":31465,"RHEA_ID":39445,"compounds":"(11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+) => (2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + NADPH"}
{"X":31466,"RHEA_ID":29528,"DIRECTION":"LR","MASTER_ID":29527,"metacyc":"RXN-5466","compounds":"alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+)"}
{"X":31467,"RHEA_ID":29529,"compounds":"alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate"}
{"X":31468,"RHEA_ID":29531,"DIRECTION":"UN","MASTER_ID":29531,"ec":"2.4.1.259","compounds":"alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate = alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+)"}
{"X":31469,"RHEA_ID":29532,"DIRECTION":"LR","MASTER_ID":29531,"metacyc":"RXN-5467","compounds":"alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+)"}
{"X":31470,"RHEA_ID":29533,"compounds":"alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate"}
{"X":31471,"RHEA_ID":29535,"DIRECTION":"UN","MASTER_ID":29535,"ec":"2.4.1.260","compounds":"alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate = alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+)"}
{"X":31472,"RHEA_ID":29536,"DIRECTION":"LR","MASTER_ID":29535,"metacyc":"RXN-5468","compounds":"alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+)"}
{"X":31473,"RHEA_ID":29537,"compounds":"alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate"}
{"X":31474,"RHEA_ID":29539,"DIRECTION":"UN","MASTER_ID":29539,"ec":"2.4.1.261","compounds":"alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate = alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+)"}
{"X":31475,"RHEA_ID":29540,"DIRECTION":"LR","MASTER_ID":29539,"metacyc":"RXN-5469","compounds":"alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+)"}
{"X":31476,"RHEA_ID":29541,"compounds":"alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-mannosyl phosphate"}
{"X":31477,"RHEA_ID":39461,"compounds":"(3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+) => (7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + H(+) + NADPH"}
{"X":31478,"RHEA_ID":29544,"DIRECTION":"LR","MASTER_ID":29543,"metacyc":"RXN-5472","compounds":"alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+)"}
{"X":31479,"RHEA_ID":29545,"compounds":"alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+) => alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate"}
{"X":31480,"RHEA_ID":39465,"compounds":"(2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O => (3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA"}
{"X":31481,"RHEA_ID":29548,"compounds":"H2O + UDP-N-acetyl-alpha-D-glucosamine => 2 H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UMP"}
{"X":31482,"RHEA_ID":29549,"compounds":"2 H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UMP => H2O + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":31483,"RHEA_ID":29550,"compounds":"H2O + UDP-N-acetyl-alpha-D-glucosamine <=> 2 H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UMP"}
{"X":31484,"RHEA_ID":39469,"compounds":"(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+) => (2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + NADPH"}
{"X":31485,"RHEA_ID":29552,"compounds":"H2O + UDP-alpha-D-glucose => alpha-D-galactose 1-phosphate + 2 H(+) + UMP"}
{"X":31486,"RHEA_ID":29553,"compounds":"alpha-D-galactose 1-phosphate + 2 H(+) + UMP => H2O + UDP-alpha-D-glucose"}
{"X":31487,"RHEA_ID":29554,"compounds":"H2O + UDP-alpha-D-glucose <=> alpha-D-galactose 1-phosphate + 2 H(+) + UMP"}
{"X":31488,"RHEA_ID":39473,"compounds":"(3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+) => (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + H(+) + NADPH"}
{"X":31489,"RHEA_ID":29556,"compounds":"H2O + UDP-alpha-D-glucose => alpha-D-glucose 1-phosphate + 2 H(+) + UMP"}
{"X":31490,"RHEA_ID":29557,"compounds":"alpha-D-glucose 1-phosphate + 2 H(+) + UMP => H2O + UDP-alpha-D-glucose"}
{"X":31491,"RHEA_ID":29558,"compounds":"H2O + UDP-alpha-D-glucose <=> alpha-D-glucose 1-phosphate + 2 H(+) + UMP"}
{"X":31492,"RHEA_ID":29559,"compounds":"H2O + UDP-alpha-D-glucuronate = 1-phospho-alpha-D-glucuronate + 2 H(+) + UMP"}
{"X":31493,"RHEA_ID":29560,"compounds":"H2O + UDP-alpha-D-glucuronate => 1-phospho-alpha-D-glucuronate + 2 H(+) + UMP"}
{"X":31494,"RHEA_ID":29561,"compounds":"1-phospho-alpha-D-glucuronate + 2 H(+) + UMP => H2O + UDP-alpha-D-glucuronate"}
{"X":31495,"RHEA_ID":29562,"compounds":"H2O + UDP-alpha-D-glucuronate <=> 1-phospho-alpha-D-glucuronate + 2 H(+) + UMP"}
{"X":31496,"RHEA_ID":39481,"compounds":"(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+) => (2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADPH"}
{"X":31497,"RHEA_ID":29564,"DIRECTION":"LR","MASTER_ID":29563,"ecocyc":"RXN0-2361","metacyc":"RXN0-2361","compounds":"ATP + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramate => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate"}
{"X":31498,"RHEA_ID":29565,"compounds":"ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate => ATP + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramate"}
{"X":31499,"RHEA_ID":39484,"compounds":"3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+)"}
{"X":31500,"RHEA_ID":29567,"compounds":"2 chloride(in) + H(+)(out) = 2 chloride(out) + H(+)(in)"}
{"X":31501,"RHEA_ID":29568,"compounds":"2 chloride(in) + H(+)(out) => 2 chloride(out) + H(+)(in)"}
{"X":31502,"RHEA_ID":29569,"compounds":"2 chloride(out) + H(+)(in) => 2 chloride(in) + H(+)(out)"}
{"X":31503,"RHEA_ID":29570,"DIRECTION":"BI","MASTER_ID":29567,"ecocyc":"RXN0-2501","compounds":"2 chloride(in) + H(+)(out) <=> 2 chloride(out) + H(+)(in)"}
{"X":31504,"RHEA_ID":39489,"compounds":"(2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H2O => (3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA"}
{"X":31505,"RHEA_ID":29572,"compounds":"H(+)(in) + L-idonate(in) => H(+)(out) + L-idonate(out)"}
{"X":31506,"RHEA_ID":29573,"DIRECTION":"RL","MASTER_ID":29571,"ecocyc":"TRANS-RXN-181A","compounds":"H(+)(out) + L-idonate(out) => H(+)(in) + L-idonate(in)"}
{"X":31507,"RHEA_ID":29574,"compounds":"H(+)(in) + L-idonate(in) <=> H(+)(out) + L-idonate(out)"}
{"X":31508,"RHEA_ID":39493,"compounds":"(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+) => (2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH"}
{"X":31509,"RHEA_ID":29576,"DIRECTION":"LR","MASTER_ID":29575,"reactome":"R-HSA-375473.1","compounds":"L-serine(in) + Na(+)(in) => L-serine(out) + Na(+)(out)"}
{"X":31510,"RHEA_ID":29576,"DIRECTION":"LR","MASTER_ID":29575,"reactome":"R-HSA-352108.1","compounds":"L-serine(in) + Na(+)(in) => L-serine(out) + Na(+)(out)"}
{"X":31511,"RHEA_ID":29576,"DIRECTION":"LR","MASTER_ID":29575,"reactome":"R-HSA-352059.1","compounds":"L-serine(in) + Na(+)(in) => L-serine(out) + Na(+)(out)"}
{"X":31512,"RHEA_ID":29577,"DIRECTION":"RL","MASTER_ID":29575,"ecocyc":"RXN0-4083","compounds":"L-serine(out) + Na(+)(out) => L-serine(in) + Na(+)(in)"}
{"X":31513,"RHEA_ID":29578,"compounds":"L-serine(in) + Na(+)(in) <=> L-serine(out) + Na(+)(out)"}
{"X":31514,"RHEA_ID":29579,"compounds":"Fe(2+)(in) + H(+)(in) = Fe(2+)(out) + H(+)(out)"}
{"X":31515,"RHEA_ID":39500,"compounds":"(3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA => (2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H2O"}
{"X":31516,"RHEA_ID":39501,"compounds":"(2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H2O => (3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA"}
{"X":31517,"RHEA_ID":29582,"compounds":"Fe(2+)(in) + H(+)(in) <=> Fe(2+)(out) + H(+)(out)"}
{"X":31518,"RHEA_ID":29583,"compounds":"guanosine(in) + H(+)(out) = guanosine(out) + H(+)(in)"}
{"X":31519,"RHEA_ID":29584,"DIRECTION":"LR","MASTER_ID":29583,"ecocyc":"RXN0-22","compounds":"guanosine(in) + H(+)(out) => guanosine(out) + H(+)(in)"}
{"X":31520,"RHEA_ID":39505,"compounds":"(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+) => (2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH"}
{"X":31521,"RHEA_ID":29586,"compounds":"guanosine(in) + H(+)(out) <=> guanosine(out) + H(+)(in)"}
{"X":31522,"RHEA_ID":29587,"DIRECTION":"UN","MASTER_ID":29587,"ec":"1.1.1.312","compounds":"4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+) = 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + NADPH"}
{"X":31523,"RHEA_ID":29588,"DIRECTION":"LR","MASTER_ID":29587,"metacyc":"1.2.1.45-RXN","compounds":"4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+) => 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + NADPH"}
{"X":31524,"RHEA_ID":29589,"compounds":"2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + NADPH => 4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+)"}
{"X":31525,"RHEA_ID":39510,"compounds":"3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+)"}
{"X":31526,"RHEA_ID":29591,"DIRECTION":"UN","MASTER_ID":29591,"ec":"1.1.1.313","compounds":"2-hydroxyethane-1-sulfonate + NADP(+) = H(+) + NADPH + sulfoacetaldehyde"}
{"X":31527,"RHEA_ID":29592,"compounds":"2-hydroxyethane-1-sulfonate + NADP(+) => H(+) + NADPH + sulfoacetaldehyde"}
{"X":31528,"RHEA_ID":39513,"compounds":"(2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H2O => (3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA"}
{"X":31529,"RHEA_ID":39514,"compounds":"(3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA <=> (2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H2O"}
{"X":31530,"RHEA_ID":29595,"DIRECTION":"UN","MASTER_ID":29595,"ec":"1.2.1.81","compounds":"CoA + NADP(+) + sulfoacetaldehyde = H(+) + NADPH + sulfoacetyl-CoA"}
{"X":31531,"RHEA_ID":29596,"compounds":"CoA + NADP(+) + sulfoacetaldehyde => H(+) + NADPH + sulfoacetyl-CoA"}
{"X":31532,"RHEA_ID":39517,"compounds":"(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+) => (2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH"}
{"X":31533,"RHEA_ID":39518,"compounds":"(2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH <=> (15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+)"}
{"X":31534,"RHEA_ID":29599,"DIRECTION":"UN","MASTER_ID":29599,"ec":"1.14.14.125","compounds":"monacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + monacolin J carboxylate + oxidized [NADPH--hemoprotein reductase]"}
{"X":31535,"RHEA_ID":29600,"DIRECTION":"LR","MASTER_ID":29599,"metacyc":"RXN-15674","compounds":"monacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + monacolin J carboxylate + oxidized [NADPH--hemoprotein reductase]"}
{"X":31536,"RHEA_ID":29601,"compounds":"H(+) + H2O + monacolin J carboxylate + oxidized [NADPH--hemoprotein reductase] => monacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":31537,"RHEA_ID":39522,"compounds":"3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+)"}
{"X":31538,"RHEA_ID":29603,"DIRECTION":"UN","MASTER_ID":29603,"ec":"1.3.7.9","compounds":"benzoyl-CoA + H2O + oxidized 2[4Fe-4S]-[ferredoxin] = 4-hydroxybenzoyl-CoA + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]"}
{"X":31539,"RHEA_ID":29604,"compounds":"benzoyl-CoA + H2O + oxidized 2[4Fe-4S]-[ferredoxin] => 4-hydroxybenzoyl-CoA + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]"}
{"X":31540,"RHEA_ID":39525,"compounds":"(2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H2O => (3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA"}
{"X":31541,"RHEA_ID":39526,"compounds":"(3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA <=> (2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H2O"}
{"X":31542,"RHEA_ID":29607,"DIRECTION":"UN","MASTER_ID":29607,"ec":"1.7.1.14","compounds":"H2O + NAD(+) + nitrous oxide = H(+) + NADH + 2 nitric oxide"}
{"X":31543,"RHEA_ID":29608,"compounds":"H2O + NAD(+) + nitrous oxide => H(+) + NADH + 2 nitric oxide"}
{"X":31544,"RHEA_ID":39529,"compounds":"(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+) => (2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH"}
{"X":31545,"RHEA_ID":29611,"DIRECTION":"UN","MASTER_ID":29611,"ec":"1.7.1.14","compounds":"H2O + NADP(+) + nitrous oxide = H(+) + NADPH + 2 nitric oxide"}
{"X":31546,"RHEA_ID":29612,"compounds":"H2O + NADP(+) + nitrous oxide => H(+) + NADPH + 2 nitric oxide"}
{"X":31547,"RHEA_ID":39533,"compounds":"(3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+) => 3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH"}
{"X":31548,"RHEA_ID":29615,"compounds":"alpha-maltotriose + beta-maltose = alpha-maltotetraose + beta-D-glucose"}
{"X":31549,"RHEA_ID":39537,"compounds":"(2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H2O => (3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA"}
{"X":31550,"RHEA_ID":29617,"compounds":"alpha-maltotetraose + beta-D-glucose => alpha-maltotriose + beta-maltose"}
{"X":31551,"RHEA_ID":29618,"DIRECTION":"BI","MASTER_ID":29615,"ecocyc":"AMYLOMALT-RXN","compounds":"alpha-maltotriose + beta-maltose <=> alpha-maltotetraose + beta-D-glucose"}
{"X":31552,"RHEA_ID":29619,"compounds":"alpha-maltotetraose + beta-maltose = alpha-maltopentaose + beta-D-glucose"}
{"X":31553,"RHEA_ID":29620,"compounds":"alpha-maltotetraose + beta-maltose => alpha-maltopentaose + beta-D-glucose"}
{"X":31554,"RHEA_ID":29621,"compounds":"alpha-maltopentaose + beta-D-glucose => alpha-maltotetraose + beta-maltose"}
{"X":31555,"RHEA_ID":29622,"compounds":"alpha-maltotetraose + beta-maltose <=> alpha-maltopentaose + beta-D-glucose"}
{"X":31556,"RHEA_ID":29623,"compounds":"alpha-maltopentaose + beta-maltose = alpha-maltohexaose + beta-D-glucose"}
{"X":31557,"RHEA_ID":29624,"compounds":"alpha-maltopentaose + beta-maltose => alpha-maltohexaose + beta-D-glucose"}
{"X":31558,"RHEA_ID":29625,"compounds":"alpha-maltohexaose + beta-D-glucose => alpha-maltopentaose + beta-maltose"}
{"X":31559,"RHEA_ID":29626,"compounds":"alpha-maltopentaose + beta-maltose <=> alpha-maltohexaose + beta-D-glucose"}
{"X":31560,"RHEA_ID":29627,"compounds":"alpha-maltohexaose + beta-maltose = alpha-maltoheptaose + beta-D-glucose"}
{"X":31561,"RHEA_ID":29628,"compounds":"alpha-maltohexaose + beta-maltose => alpha-maltoheptaose + beta-D-glucose"}
{"X":31562,"RHEA_ID":29629,"compounds":"alpha-maltoheptaose + beta-D-glucose => alpha-maltohexaose + beta-maltose"}
{"X":31563,"RHEA_ID":29630,"compounds":"alpha-maltohexaose + beta-maltose <=> alpha-maltoheptaose + beta-D-glucose"}
{"X":31564,"RHEA_ID":29631,"compounds":"alpha-maltotetraose + H2O = alpha-D-glucose + alpha-maltotriose"}
{"X":31565,"RHEA_ID":29632,"compounds":"alpha-maltotetraose + H2O => alpha-D-glucose + alpha-maltotriose"}
{"X":31566,"RHEA_ID":39554,"compounds":"(2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH <=> (21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+)"}
{"X":31567,"RHEA_ID":29634,"compounds":"alpha-maltotetraose + H2O <=> alpha-D-glucose + alpha-maltotriose"}
{"X":31568,"RHEA_ID":29635,"compounds":"alpha-maltopentaose + H2O = alpha-D-glucose + alpha-maltotetraose"}
{"X":31569,"RHEA_ID":29636,"compounds":"alpha-maltopentaose + H2O => alpha-D-glucose + alpha-maltotetraose"}
{"X":31570,"RHEA_ID":39558,"compounds":"3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+)"}
{"X":31571,"RHEA_ID":29638,"compounds":"alpha-maltopentaose + H2O <=> alpha-D-glucose + alpha-maltotetraose"}
{"X":31572,"RHEA_ID":29639,"compounds":"alpha-maltohexaose + H2O = alpha-D-glucose + alpha-maltopentaose"}
{"X":31573,"RHEA_ID":29640,"compounds":"alpha-maltohexaose + H2O => alpha-D-glucose + alpha-maltopentaose"}
{"X":31574,"RHEA_ID":39562,"compounds":"(3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA <=> (2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H2O"}
{"X":31575,"RHEA_ID":29642,"compounds":"alpha-maltohexaose + H2O <=> alpha-D-glucose + alpha-maltopentaose"}
{"X":31576,"RHEA_ID":29643,"compounds":"alpha-maltoheptaose + H2O = alpha-D-glucose + alpha-maltohexaose"}
{"X":31577,"RHEA_ID":29644,"compounds":"alpha-maltoheptaose + H2O => alpha-D-glucose + alpha-maltohexaose"}
{"X":31578,"RHEA_ID":39566,"compounds":"(2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H(+) + NADPH <=> (23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+)"}
{"X":31579,"RHEA_ID":29646,"compounds":"alpha-maltoheptaose + H2O <=> alpha-D-glucose + alpha-maltohexaose"}
{"X":31580,"RHEA_ID":29647,"compounds":"alpha-maltopentaose + phosphate = alpha-D-glucose 1-phosphate + alpha-maltotetraose"}
{"X":31581,"RHEA_ID":29648,"compounds":"alpha-maltopentaose + phosphate => alpha-D-glucose 1-phosphate + alpha-maltotetraose"}
{"X":31582,"RHEA_ID":39570,"compounds":"(11Z,14Z)-eicosadienoyl-CoA + AH2 + O2 <=> (8Z,11Z,14Z)-eicosatrienoyl-CoA + A + 2 H2O"}
{"X":31583,"RHEA_ID":29650,"compounds":"alpha-maltopentaose + phosphate <=> alpha-D-glucose 1-phosphate + alpha-maltotetraose"}
{"X":31584,"RHEA_ID":29651,"compounds":"agmatine(in) + L-arginine(out) = agmatine(out) + L-arginine(in)"}
{"X":31585,"RHEA_ID":29652,"DIRECTION":"LR","MASTER_ID":29651,"ecocyc":"RXN0-2162","compounds":"agmatine(in) + L-arginine(out) => agmatine(out) + L-arginine(in)"}
{"X":31586,"RHEA_ID":29653,"compounds":"agmatine(out) + L-arginine(in) => agmatine(in) + L-arginine(out)"}
{"X":31587,"RHEA_ID":29654,"compounds":"agmatine(in) + L-arginine(out) <=> agmatine(out) + L-arginine(in)"}
{"X":31588,"RHEA_ID":29655,"compounds":"L-cysteine(in) = L-cysteine(out)"}
{"X":31589,"RHEA_ID":29656,"DIRECTION":"LR","MASTER_ID":29655,"ecocyc":"RXN0-1924","reactome":"R-HSA-376200.1","compounds":"L-cysteine(in) => L-cysteine(out)"}
{"X":31590,"RHEA_ID":29657,"compounds":"L-cysteine(out) => L-cysteine(in)"}
{"X":31591,"RHEA_ID":29658,"compounds":"L-cysteine(in) <=> L-cysteine(out)"}
{"X":31592,"RHEA_ID":39580,"compounds":"(3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA => (2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H2O"}
{"X":31593,"RHEA_ID":29660,"DIRECTION":"LR","MASTER_ID":29659,"ecocyc":"RXN0-1923","compounds":"O-acetyl-L-serine(in) => O-acetyl-L-serine(out)"}
{"X":31594,"RHEA_ID":29661,"compounds":"O-acetyl-L-serine(out) => O-acetyl-L-serine(in)"}
{"X":31595,"RHEA_ID":29662,"compounds":"O-acetyl-L-serine(in) <=> O-acetyl-L-serine(out)"}
{"X":31596,"RHEA_ID":29663,"compounds":"H(+)(in) + xanthine(in) = H(+)(out) + xanthine(out)"}
{"X":31597,"RHEA_ID":29664,"compounds":"H(+)(in) + xanthine(in) => H(+)(out) + xanthine(out)"}
{"X":31598,"RHEA_ID":29665,"DIRECTION":"RL","MASTER_ID":29663,"ecocyc":"RXN-5076","compounds":"H(+)(out) + xanthine(out) => H(+)(in) + xanthine(in)"}
{"X":31599,"RHEA_ID":29666,"compounds":"H(+)(in) + xanthine(in) <=> H(+)(out) + xanthine(out)"}
{"X":31600,"RHEA_ID":29667,"compounds":"H2O(in) = H2O(out)"}
{"X":31601,"RHEA_ID":29668,"DIRECTION":"LR","MASTER_ID":29667,"reactome":"R-HSA-432010.2","compounds":"H2O(in) => H2O(out)"}
{"X":31602,"RHEA_ID":29668,"DIRECTION":"LR","MASTER_ID":29667,"reactome":"R-HSA-432065.2","compounds":"H2O(in) => H2O(out)"}
{"X":31603,"RHEA_ID":29668,"DIRECTION":"LR","MASTER_ID":29667,"reactome":"R-HSA-507868.4","compounds":"H2O(in) => H2O(out)"}
{"X":31604,"RHEA_ID":29669,"DIRECTION":"RL","MASTER_ID":29667,"reactome":"R-HSA-445714.2","compounds":"H2O(out) => H2O(in)"}
{"X":31605,"RHEA_ID":29669,"DIRECTION":"RL","MASTER_ID":29667,"reactome":"R-HSA-432054.2","compounds":"H2O(out) => H2O(in)"}
{"X":31606,"RHEA_ID":29669,"DIRECTION":"RL","MASTER_ID":29667,"reactome":"R-HSA-432067.2","compounds":"H2O(out) => H2O(in)"}
{"X":31607,"RHEA_ID":29669,"DIRECTION":"RL","MASTER_ID":29667,"reactome":"R-HSA-507870.4","compounds":"H2O(out) => H2O(in)"}
{"X":31608,"RHEA_ID":39596,"compounds":"(2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H(+) + NADPH => (10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+)"}
{"X":31609,"RHEA_ID":29671,"compounds":"Ca(2+)(in) = Ca(2+)(out)"}
{"X":31610,"RHEA_ID":29672,"DIRECTION":"LR","MASTER_ID":29671,"ecocyc":"TRANS-RXN-144","reactome":"R-HSA-629595.2","compounds":"Ca(2+)(in) => Ca(2+)(out)"}
{"X":31611,"RHEA_ID":29672,"DIRECTION":"LR","MASTER_ID":29671,"ecocyc":"TRANS-RXN-144","reactome":"R-HSA-169683.3","compounds":"Ca(2+)(in) => Ca(2+)(out)"}
{"X":31612,"RHEA_ID":39600,"compounds":"3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+)"}
{"X":31613,"RHEA_ID":29672,"DIRECTION":"LR","MASTER_ID":29671,"ecocyc":"TRANS-RXN-144","reactome":"R-HSA-5263618.1","compounds":"Ca(2+)(in) => Ca(2+)(out)"}
{"X":31614,"RHEA_ID":29672,"DIRECTION":"LR","MASTER_ID":29671,"ecocyc":"TRANS-RXN-144","reactome":"R-HSA-2534359.1","compounds":"Ca(2+)(in) => Ca(2+)(out)"}
{"X":31615,"RHEA_ID":29672,"DIRECTION":"LR","MASTER_ID":29671,"ecocyc":"TRANS-RXN-144","reactome":"R-HSA-622326.2","compounds":"Ca(2+)(in) => Ca(2+)(out)"}
{"X":31616,"RHEA_ID":39604,"compounds":"(3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA => (2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H2O"}
{"X":31617,"RHEA_ID":29672,"DIRECTION":"LR","MASTER_ID":29671,"ecocyc":"TRANS-RXN-144","reactome":"R-HSA-434798.1","compounds":"Ca(2+)(in) => Ca(2+)(out)"}
{"X":31618,"RHEA_ID":29672,"DIRECTION":"LR","MASTER_ID":29671,"ecocyc":"TRANS-RXN-144","reactome":"R-HSA-426223.1","compounds":"Ca(2+)(in) => Ca(2+)(out)"}
{"X":31619,"RHEA_ID":29672,"DIRECTION":"LR","MASTER_ID":29671,"ecocyc":"TRANS-RXN-144","reactome":"R-HSA-2089943.2","compounds":"Ca(2+)(in) => Ca(2+)(out)"}
{"X":31620,"RHEA_ID":39608,"compounds":"(2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H(+) + NADPH => (12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+)"}
{"X":31621,"RHEA_ID":29672,"DIRECTION":"LR","MASTER_ID":29671,"ecocyc":"TRANS-RXN-144","reactome":"R-HSA-4420052.2","compounds":"Ca(2+)(in) => Ca(2+)(out)"}
{"X":31622,"RHEA_ID":29672,"DIRECTION":"LR","MASTER_ID":29671,"ecocyc":"TRANS-RXN-144","reactome":"R-HSA-265645.1","compounds":"Ca(2+)(in) => Ca(2+)(out)"}
{"X":31623,"RHEA_ID":29672,"DIRECTION":"LR","MASTER_ID":29671,"ecocyc":"TRANS-RXN-144","reactome":"R-HSA-432164.4","compounds":"Ca(2+)(in) => Ca(2+)(out)"}
{"X":31624,"RHEA_ID":29672,"DIRECTION":"LR","MASTER_ID":29671,"ecocyc":"TRANS-RXN-144","reactome":"R-HSA-210420.3","compounds":"Ca(2+)(in) => Ca(2+)(out)"}
{"X":31625,"RHEA_ID":29672,"DIRECTION":"LR","MASTER_ID":29671,"ecocyc":"TRANS-RXN-144","reactome":"R-HSA-3295579.3","compounds":"Ca(2+)(in) => Ca(2+)(out)"}
{"X":31626,"RHEA_ID":29672,"DIRECTION":"LR","MASTER_ID":29671,"ecocyc":"TRANS-RXN-144","reactome":"R-HSA-451311.2","compounds":"Ca(2+)(in) => Ca(2+)(out)"}
{"X":31627,"RHEA_ID":29672,"DIRECTION":"LR","MASTER_ID":29671,"ecocyc":"TRANS-RXN-144","reactome":"R-HSA-399712.4","compounds":"Ca(2+)(in) => Ca(2+)(out)"}
{"X":31628,"RHEA_ID":39616,"compounds":"(3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA => (2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H2O"}
{"X":31629,"RHEA_ID":29673,"DIRECTION":"RL","MASTER_ID":29671,"reactome":"R-HSA-2685505.2","compounds":"Ca(2+)(out) => Ca(2+)(in)"}
{"X":31630,"RHEA_ID":29673,"DIRECTION":"RL","MASTER_ID":29671,"reactome":"R-HSA-8949145.1","compounds":"Ca(2+)(out) => Ca(2+)(in)"}
{"X":31631,"RHEA_ID":29674,"compounds":"Ca(2+)(in) <=> Ca(2+)(out)"}
{"X":31632,"RHEA_ID":39620,"compounds":"(2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H(+) + NADPH => (14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+)"}
{"X":31633,"RHEA_ID":29676,"DIRECTION":"LR","MASTER_ID":29675,"reactome":"R-HSA-507869.3","compounds":"glycerol(in) => glycerol(out)"}
{"X":31634,"RHEA_ID":29676,"DIRECTION":"LR","MASTER_ID":29675,"reactome":"R-HSA-432049.3","compounds":"glycerol(in) => glycerol(out)"}
{"X":31635,"RHEA_ID":29677,"DIRECTION":"RL","MASTER_ID":29675,"metacyc":"TRANS-RXN-131","reactome":"R-HSA-507871.3","compounds":"glycerol(out) => glycerol(in)"}
{"X":31636,"RHEA_ID":29677,"DIRECTION":"RL","MASTER_ID":29675,"metacyc":"TRANS-RXN-131","reactome":"R-HSA-432074.3","compounds":"glycerol(out) => glycerol(in)"}
{"X":31637,"RHEA_ID":29678,"DIRECTION":"BI","MASTER_ID":29675,"ecocyc":"TRANS-RXN-131","compounds":"glycerol(in) <=> glycerol(out)"}
{"X":31638,"RHEA_ID":29679,"compounds":"formate(in) = formate(out)"}
{"X":31639,"RHEA_ID":29680,"DIRECTION":"LR","MASTER_ID":29679,"ecocyc":"TRANS-RXN-1","compounds":"formate(in) => formate(out)"}
{"X":31640,"RHEA_ID":39628,"compounds":"(3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA => (2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H2O"}
{"X":31641,"RHEA_ID":29682,"compounds":"formate(in) <=> formate(out)"}
{"X":31642,"RHEA_ID":29683,"compounds":"alpha-maltohexaose + phosphate = alpha-D-glucose 1-phosphate + alpha-maltopentaose"}
{"X":31643,"RHEA_ID":29684,"compounds":"alpha-maltohexaose + phosphate => alpha-D-glucose 1-phosphate + alpha-maltopentaose"}
{"X":31644,"RHEA_ID":29685,"compounds":"alpha-D-glucose 1-phosphate + alpha-maltopentaose => alpha-maltohexaose + phosphate"}
{"X":31645,"RHEA_ID":29686,"compounds":"alpha-maltohexaose + phosphate <=> alpha-D-glucose 1-phosphate + alpha-maltopentaose"}
{"X":31646,"RHEA_ID":29687,"compounds":"alpha-maltoheptaose + phosphate = alpha-D-glucose 1-phosphate + alpha-maltohexaose"}
{"X":31647,"RHEA_ID":29688,"compounds":"alpha-maltoheptaose + phosphate => alpha-D-glucose 1-phosphate + alpha-maltohexaose"}
{"X":31648,"RHEA_ID":39636,"compounds":"3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+)"}
{"X":31649,"RHEA_ID":29690,"compounds":"alpha-maltoheptaose + phosphate <=> alpha-D-glucose 1-phosphate + alpha-maltohexaose"}
{"X":31650,"RHEA_ID":29691,"compounds":"alpha-maltotetraose + phosphate = alpha-D-glucose 1-phosphate + alpha-maltotriose"}
{"X":31651,"RHEA_ID":29692,"compounds":"alpha-maltotetraose + phosphate => alpha-D-glucose 1-phosphate + alpha-maltotriose"}
{"X":31652,"RHEA_ID":29693,"compounds":"alpha-D-glucose 1-phosphate + alpha-maltotriose => alpha-maltotetraose + phosphate"}
{"X":31653,"RHEA_ID":39641,"compounds":"(2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H2O => (3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA"}
{"X":31654,"RHEA_ID":29695,"compounds":"cob(I)inamide(in) = cob(I)inamide(out)"}
{"X":31655,"RHEA_ID":29696,"compounds":"cob(I)inamide(in) => cob(I)inamide(out)"}
{"X":31656,"RHEA_ID":29697,"DIRECTION":"RL","MASTER_ID":29695,"ecocyc":"TRANS-RXN0-283","compounds":"cob(I)inamide(out) => cob(I)inamide(in)"}
{"X":31657,"RHEA_ID":39645,"compounds":"(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+) => (2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H(+) + NADPH"}
{"X":31658,"RHEA_ID":29698,"compounds":"cob(I)inamide(in) <=> cob(I)inamide(out)"}
{"X":31659,"RHEA_ID":29699,"compounds":"dimethyl sulfoxide(in) = dimethyl sulfoxide(out)"}
{"X":31660,"RHEA_ID":29700,"compounds":"dimethyl sulfoxide(in) => dimethyl sulfoxide(out)"}
{"X":31661,"RHEA_ID":39649,"compounds":"5'-deoxyadenosine + A + dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + H(+) + L-methionine + NH4(+) => AH2 + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose + S-adenosyl-L-methionine"}
{"X":31662,"RHEA_ID":29702,"compounds":"dimethyl sulfoxide(in) <=> dimethyl sulfoxide(out)"}
{"X":31663,"RHEA_ID":29703,"compounds":"L-valine(in) = L-valine(out)"}
{"X":31664,"RHEA_ID":29704,"DIRECTION":"LR","MASTER_ID":29703,"ecocyc":"TRANS-RXN0-269","reactome":"R-HSA-352191.2","compounds":"L-valine(in) => L-valine(out)"}
{"X":31665,"RHEA_ID":39653,"compounds":"3-hydroxy-6-carboxyhexanoyl-CoA + H(+) => 6-oxocyclohex-1-ene-1-carbonyl-CoA + 2 H2O"}
{"X":31666,"RHEA_ID":29704,"DIRECTION":"LR","MASTER_ID":29703,"ecocyc":"TRANS-RXN0-269","reactome":"R-HSA-352232.3","compounds":"L-valine(in) => L-valine(out)"}
{"X":31667,"RHEA_ID":29704,"DIRECTION":"LR","MASTER_ID":29703,"ecocyc":"TRANS-RXN0-269","reactome":"R-HSA-352103.1","compounds":"L-valine(in) => L-valine(out)"}
{"X":31668,"RHEA_ID":29705,"compounds":"L-valine(out) => L-valine(in)"}
{"X":31669,"RHEA_ID":39657,"compounds":"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + A + 2 H2O => (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + AH2 + O2"}
{"X":31670,"RHEA_ID":29707,"compounds":"1,6-anhydro-N-acetyl-beta-muramate(in) = 1,6-anhydro-N-acetyl-beta-muramate(out)"}
{"X":31671,"RHEA_ID":29708,"compounds":"1,6-anhydro-N-acetyl-beta-muramate(in) => 1,6-anhydro-N-acetyl-beta-muramate(out)"}
{"X":31672,"RHEA_ID":33001,"compounds":"(+)-artemisinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => (+)-amorpha-4,11-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]"}
{"X":31673,"RHEA_ID":39661,"compounds":"1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine => 3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine"}
{"X":31674,"RHEA_ID":29711,"compounds":"cadaverine(in) + H(+)(in) = cadaverine(out) + H(+)(out)"}
{"X":31675,"RHEA_ID":29712,"compounds":"cadaverine(in) + H(+)(in) => cadaverine(out) + H(+)(out)"}
{"X":31676,"RHEA_ID":29713,"DIRECTION":"RL","MASTER_ID":29711,"ecocyc":"TRANS-RXN0-212","compounds":"cadaverine(out) + H(+)(out) => cadaverine(in) + H(+)(in)"}
{"X":31677,"RHEA_ID":39665,"compounds":"a quinone + reduced coenzyme F420-(gamma-Glu)(n) => a quinol + H(+) + oxidized coenzyme F420-(gamma-Glu)(n)"}
{"X":31678,"RHEA_ID":29715,"compounds":"2-hydroxyethane-1-sulfonate + FMNH2 + O2 = FMN + glycolaldehyde + 2 H(+) + H2O + sulfite"}
{"X":31679,"RHEA_ID":29716,"compounds":"2-hydroxyethane-1-sulfonate + FMNH2 + O2 => FMN + glycolaldehyde + 2 H(+) + H2O + sulfite"}
{"X":31680,"RHEA_ID":29717,"compounds":"FMN + glycolaldehyde + 2 H(+) + H2O + sulfite => 2-hydroxyethane-1-sulfonate + FMNH2 + O2"}
{"X":31681,"RHEA_ID":39669,"compounds":"a ketone + reduced coenzyme F420-(gamma-Glu)(n) => a secondary alcohol + H(+) + oxidized coenzyme F420-(gamma-Glu)(n)"}
{"X":31682,"RHEA_ID":29719,"compounds":"cob(I)alamin(in) = cob(I)alamin(out)"}
{"X":31683,"RHEA_ID":29720,"compounds":"cob(I)alamin(in) => cob(I)alamin(out)"}
{"X":31684,"RHEA_ID":29721,"DIRECTION":"RL","MASTER_ID":29719,"ecocyc":"RXN0-2121","compounds":"cob(I)alamin(out) => cob(I)alamin(in)"}
{"X":31685,"RHEA_ID":29721,"DIRECTION":"RL","MASTER_ID":29719,"ecocyc":"RXN0-1565","compounds":"cob(I)alamin(out) => cob(I)alamin(in)"}
{"X":31686,"RHEA_ID":29722,"compounds":"cob(I)alamin(in) <=> cob(I)alamin(out)"}
{"X":31687,"RHEA_ID":29723,"compounds":"glyoxylate(in) = glyoxylate(out)"}
{"X":31688,"RHEA_ID":29724,"compounds":"glyoxylate(in) => glyoxylate(out)"}
{"X":31689,"RHEA_ID":39677,"compounds":"3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoA => (9Z)-hexadecenoyl-CoA + H(+) + malonyl-CoA"}
{"X":31690,"RHEA_ID":29725,"DIRECTION":"RL","MASTER_ID":29723,"ecocyc":"RXN0-1982","reactome":"R-HSA-6784436.3","compounds":"glyoxylate(out) => glyoxylate(in)"}
{"X":31691,"RHEA_ID":29726,"compounds":"glyoxylate(in) <=> glyoxylate(out)"}
{"X":31692,"RHEA_ID":29727,"compounds":"ethane-1-sulfonate + FMNH2 + O2 = acetaldehyde + FMN + 2 H(+) + H2O + sulfite"}
{"X":31693,"RHEA_ID":29728,"compounds":"ethane-1-sulfonate + FMNH2 + O2 => acetaldehyde + FMN + 2 H(+) + H2O + sulfite"}
{"X":31694,"RHEA_ID":29729,"compounds":"acetaldehyde + FMN + 2 H(+) + H2O + sulfite => ethane-1-sulfonate + FMNH2 + O2"}
{"X":31695,"RHEA_ID":29730,"compounds":"ethane-1-sulfonate + FMNH2 + O2 <=> acetaldehyde + FMN + 2 H(+) + H2O + sulfite"}
{"X":31696,"RHEA_ID":29731,"compounds":"beta-maltose(in) = beta-maltose(out)"}
{"X":31697,"RHEA_ID":39685,"compounds":"(R)-3-hydroxy-(11Z)-octadecenoyl-CoA + NADP(+) => 3-oxo-(11Z)-octadecenoyl-CoA + H(+) + NADPH"}
{"X":31698,"RHEA_ID":29733,"DIRECTION":"RL","MASTER_ID":29731,"ecocyc":"RXN0-1741","compounds":"beta-maltose(out) => beta-maltose(in)"}
{"X":31699,"RHEA_ID":29734,"compounds":"beta-maltose(in) <=> beta-maltose(out)"}
{"X":31700,"RHEA_ID":29735,"compounds":"butane-1-sulfonate + FMNH2 + O2 = butanal + FMN + 2 H(+) + H2O + sulfite"}
{"X":31701,"RHEA_ID":39689,"compounds":"(2E,11Z)-octadecadienoyl-CoA + H2O => (R)-3-hydroxy-(11Z)-octadecenoyl-CoA"}
{"X":31702,"RHEA_ID":29737,"compounds":"butanal + FMN + 2 H(+) + H2O + sulfite => butane-1-sulfonate + FMNH2 + O2"}
{"X":31703,"RHEA_ID":29738,"compounds":"butane-1-sulfonate + FMNH2 + O2 <=> butanal + FMN + 2 H(+) + H2O + sulfite"}
{"X":31704,"RHEA_ID":29739,"compounds":"ATP + beta-maltose(out) + H2O = ADP + beta-maltose(in) + H(+) + phosphate"}
{"X":31705,"RHEA_ID":29740,"DIRECTION":"LR","MASTER_ID":29739,"ecocyc":"ABC-16-RXN","compounds":"ATP + beta-maltose(out) + H2O => ADP + beta-maltose(in) + H(+) + phosphate"}
{"X":31706,"RHEA_ID":29741,"compounds":"ADP + beta-maltose(in) + H(+) + phosphate => ATP + beta-maltose(out) + H2O"}
{"X":31707,"RHEA_ID":29742,"compounds":"ATP + beta-maltose(out) + H2O <=> ADP + beta-maltose(in) + H(+) + phosphate"}
{"X":31708,"RHEA_ID":29743,"compounds":"2-phenylethylamine(in) = 2-phenylethylamine(out)"}
{"X":31709,"RHEA_ID":39697,"compounds":"(R)-3-hydroxy-(13Z)-eicosenoyl-CoA + NADP(+) => 3-oxo-(13Z)-eicosenoyl-CoA + H(+) + NADPH"}
{"X":31710,"RHEA_ID":29745,"DIRECTION":"RL","MASTER_ID":29743,"ecocyc":"TRANS-RXN0-284","compounds":"2-phenylethylamine(out) => 2-phenylethylamine(in)"}
{"X":31711,"RHEA_ID":29746,"compounds":"2-phenylethylamine(in) <=> 2-phenylethylamine(out)"}
{"X":31712,"RHEA_ID":29747,"compounds":"3-phenylpropanoate(in) = 3-phenylpropanoate(out)"}
{"X":31713,"RHEA_ID":29748,"compounds":"3-phenylpropanoate(in) => 3-phenylpropanoate(out)"}
{"X":31714,"RHEA_ID":29749,"DIRECTION":"RL","MASTER_ID":29747,"ecocyc":"TRANS-RXN0-282","compounds":"3-phenylpropanoate(out) => 3-phenylpropanoate(in)"}
{"X":31715,"RHEA_ID":29750,"compounds":"3-phenylpropanoate(in) <=> 3-phenylpropanoate(out)"}
{"X":31716,"RHEA_ID":29751,"compounds":"acetoacetate(in) = acetoacetate(out)"}
{"X":31717,"RHEA_ID":39705,"compounds":"(13Z)-eicosenoyl-CoA + NADP(+) => (2E,13Z)-eicosadienoyl-CoA + H(+) + NADPH"}
{"X":31718,"RHEA_ID":29753,"DIRECTION":"RL","MASTER_ID":29751,"ecocyc":"TRANS-RXN0-281","compounds":"acetoacetate(out) => acetoacetate(in)"}
{"X":31719,"RHEA_ID":29754,"compounds":"acetoacetate(in) <=> acetoacetate(out)"}
{"X":31720,"RHEA_ID":29755,"compounds":"(R)-lipoate(in) = (R)-lipoate(out)"}
{"X":31721,"RHEA_ID":39709,"compounds":"a long-chain fatty acyl-CoA(in) => a long-chain fatty acyl-CoA(out)"}
{"X":31722,"RHEA_ID":29757,"compounds":"(R)-lipoate(out) => (R)-lipoate(in)"}
{"X":31723,"RHEA_ID":29758,"compounds":"(R)-lipoate(in) <=> (R)-lipoate(out)"}
{"X":31724,"RHEA_ID":29759,"compounds":"octanoate(in) = octanoate(out)"}
{"X":31725,"RHEA_ID":29760,"compounds":"octanoate(in) => octanoate(out)"}
{"X":31726,"RHEA_ID":49610,"compounds":"2-glutathionyl-2-methylbut-3-enoate + 2 H(+) + NADH => 2-glutathionyl-2-methylbut-3-enal + H2O + NAD(+)"}
{"X":31727,"RHEA_ID":29762,"compounds":"octanoate(in) <=> octanoate(out)"}
{"X":31728,"RHEA_ID":29763,"compounds":"ATP + H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) = ADP + H(+) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in) + phosphate"}
{"X":31729,"RHEA_ID":29764,"DIRECTION":"LR","MASTER_ID":29763,"ecocyc":"TRANS-RXN0-268","compounds":"ATP + H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) => ADP + H(+) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in) + phosphate"}
{"X":31730,"RHEA_ID":39718,"compounds":"(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + AH2 + O2 <=> (6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + A + 2 H2O"}
{"X":31731,"RHEA_ID":29766,"compounds":"ATP + H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) <=> ADP + H(+) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in) + phosphate"}
{"X":31732,"RHEA_ID":29767,"DIRECTION":"UN","MASTER_ID":29767,"ec":"7.4.2.11","compounds":"ATP + D-methionine(out) + H2O = ADP + D-methionine(in) + H(+) + phosphate"}
{"X":31733,"RHEA_ID":29768,"DIRECTION":"LR","MASTER_ID":29767,"ecocyc":"TRANS-RXN0-202","compounds":"ATP + D-methionine(out) + H2O => ADP + D-methionine(in) + H(+) + phosphate"}
{"X":31734,"RHEA_ID":39722,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + tetracosanoate <=> 24-hydroxytetracosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":31735,"RHEA_ID":29770,"compounds":"ATP + D-methionine(out) + H2O <=> ADP + D-methionine(in) + H(+) + phosphate"}
{"X":31736,"RHEA_ID":29771,"compounds":"arsenate(in) + ATP + H2O = ADP + arsenate(out) + H(+) + phosphate"}
{"X":31737,"RHEA_ID":29772,"DIRECTION":"LR","MASTER_ID":29771,"ecocyc":"TRANS-RXN-7","compounds":"arsenate(in) + ATP + H2O => ADP + arsenate(out) + H(+) + phosphate"}
{"X":31738,"RHEA_ID":39726,"compounds":"a 1,2-diacyl-sn-glycerol(in) <=> a 1,2-diacyl-sn-glycerol(out)"}
{"X":31739,"RHEA_ID":29774,"compounds":"arsenate(in) + ATP + H2O <=> ADP + arsenate(out) + H(+) + phosphate"}
{"X":31740,"RHEA_ID":29775,"compounds":"alpha-D-ribose 1-phosphate + ATP = ADP + alpha-D-ribose 1,5-bisphosphate + H(+)"}
{"X":31741,"RHEA_ID":29776,"DIRECTION":"LR","MASTER_ID":29775,"ecocyc":"RXN0-1402","compounds":"alpha-D-ribose 1-phosphate + ATP => ADP + alpha-D-ribose 1,5-bisphosphate + H(+)"}
{"X":31742,"RHEA_ID":39730,"compounds":"sphingomyelin(in) <=> sphingomyelin(out)"}
{"X":31743,"RHEA_ID":29778,"compounds":"alpha-D-ribose 1-phosphate + ATP <=> ADP + alpha-D-ribose 1,5-bisphosphate + H(+)"}
{"X":31744,"RHEA_ID":29779,"DIRECTION":"UN","MASTER_ID":29779,"ec":"7.4.2.11","compounds":"ATP + H2O + L-methionine(out) = ADP + H(+) + L-methionine(in) + phosphate"}
{"X":31745,"RHEA_ID":29780,"DIRECTION":"LR","MASTER_ID":29779,"ecocyc":"RXN0-4522","compounds":"ATP + H2O + L-methionine(out) => ADP + H(+) + L-methionine(in) + phosphate"}
{"X":31746,"RHEA_ID":29781,"compounds":"ADP + H(+) + L-methionine(in) + phosphate => ATP + H2O + L-methionine(out)"}
{"X":31747,"RHEA_ID":29782,"compounds":"ATP + H2O + L-methionine(out) <=> ADP + H(+) + L-methionine(in) + phosphate"}
{"X":31748,"RHEA_ID":29783,"compounds":"ATP + H2O + L-cysteine(in) = ADP + H(+) + L-cysteine(out) + phosphate"}
{"X":31749,"RHEA_ID":29784,"DIRECTION":"LR","MASTER_ID":29783,"ecocyc":"RXN0-3","compounds":"ATP + H2O + L-cysteine(in) => ADP + H(+) + L-cysteine(out) + phosphate"}
{"X":31750,"RHEA_ID":39738,"compounds":"3-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 3,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":31751,"RHEA_ID":29786,"compounds":"ATP + H2O + L-cysteine(in) <=> ADP + H(+) + L-cysteine(out) + phosphate"}
{"X":31752,"RHEA_ID":29787,"compounds":"ATP + glutathione(in) + H2O = ADP + glutathione(out) + H(+) + phosphate"}
{"X":31753,"RHEA_ID":29788,"DIRECTION":"LR","MASTER_ID":29787,"ecocyc":"RXN0-11","compounds":"ATP + glutathione(in) + H2O => ADP + glutathione(out) + H(+) + phosphate"}
{"X":31754,"RHEA_ID":39742,"compounds":"3-hydroxydodecanoate + H(+) + NADPH + O2 <=> 3,12-dihydroxydodecanoate + H2O + NADP(+)"}
{"X":31755,"RHEA_ID":29790,"compounds":"ATP + glutathione(in) + H2O <=> ADP + glutathione(out) + H(+) + phosphate"}
{"X":31756,"RHEA_ID":29791,"DIRECTION":"UN","MASTER_ID":29791,"ec":"7.4.2.10","compounds":"ATP + glutathione(out) + H2O = ADP + glutathione(in) + H(+) + phosphate"}
{"X":31757,"RHEA_ID":29792,"DIRECTION":"LR","MASTER_ID":29791,"ecocyc":"RXN0-21","metacyc":"RXN0-11","compounds":"ATP + glutathione(out) + H2O => ADP + glutathione(in) + H(+) + phosphate"}
{"X":31758,"RHEA_ID":29793,"compounds":"ADP + glutathione(in) + H(+) + phosphate => ATP + glutathione(out) + H2O"}
{"X":31759,"RHEA_ID":29794,"compounds":"ATP + glutathione(out) + H2O <=> ADP + glutathione(in) + H(+) + phosphate"}
{"X":31760,"RHEA_ID":29795,"DIRECTION":"UN","MASTER_ID":29795,"ec":"7.2.2.20","compounds":"ATP(in) + H2O(in) + Zn(2+)(out) = ADP(in) + H(+)(in) + phosphate(in) + Zn(2+)(in)"}
{"X":31761,"RHEA_ID":29796,"DIRECTION":"LR","MASTER_ID":29795,"ecocyc":"ABC-63-RXN","metacyc":"ABC-63-RXN","compounds":"ATP(in) + H2O(in) + Zn(2+)(out) => ADP(in) + H(+)(in) + phosphate(in) + Zn(2+)(in)"}
{"X":31762,"RHEA_ID":39749,"DIRECTION":"RL","MASTER_ID":39747,"reactome":"R-HSA-5250531.2","compounds":"cholesterol(out) => cholesterol(in)"}
{"X":31763,"RHEA_ID":29798,"compounds":"ATP(in) + H2O(in) + Zn(2+)(out) <=> ADP(in) + H(+)(in) + phosphate(in) + Zn(2+)(in)"}
{"X":31764,"RHEA_ID":29799,"DIRECTION":"UN","MASTER_ID":29799,"ec":"7.5.2.8","compounds":"ATP + D-allose(out) + H2O = ADP + D-allose(in) + H(+) + phosphate"}
{"X":31765,"RHEA_ID":29800,"DIRECTION":"LR","MASTER_ID":29799,"ecocyc":"ABC-42-RXN","metacyc":"ABC-42-RXN","compounds":"ATP + D-allose(out) + H2O => ADP + D-allose(in) + H(+) + phosphate"}
{"X":31766,"RHEA_ID":39753,"compounds":"11-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":31767,"RHEA_ID":29802,"compounds":"ATP + D-allose(out) + H2O <=> ADP + D-allose(in) + H(+) + phosphate"}
{"X":31768,"RHEA_ID":29803,"compounds":"ATP + H2O + L-valine(in) = ADP + H(+) + L-valine(out) + phosphate"}
{"X":31769,"RHEA_ID":29804,"DIRECTION":"LR","MASTER_ID":29803,"ecocyc":"ABC-36-RXN","compounds":"ATP + H2O + L-valine(in) => ADP + H(+) + L-valine(out) + phosphate"}
{"X":31770,"RHEA_ID":39757,"compounds":"20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":31771,"RHEA_ID":29806,"compounds":"ATP + H2O + L-valine(in) <=> ADP + H(+) + L-valine(out) + phosphate"}
{"X":31772,"RHEA_ID":29807,"compounds":"ATP + H2O + L-leucine(out) = ADP + H(+) + L-leucine(in) + phosphate"}
{"X":31773,"RHEA_ID":29808,"DIRECTION":"LR","MASTER_ID":29807,"ecocyc":"ABC-35-RXN","compounds":"ATP + H2O + L-leucine(out) => ADP + H(+) + L-leucine(in) + phosphate"}
{"X":31774,"RHEA_ID":39761,"compounds":"19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":31775,"RHEA_ID":29810,"compounds":"ATP + H2O + L-leucine(out) <=> ADP + H(+) + L-leucine(in) + phosphate"}
{"X":31776,"RHEA_ID":29811,"DIRECTION":"UN","MASTER_ID":29811,"ec":"7.6.2.15","compounds":"ATP + H2O + thiamine(out) = ADP + H(+) + phosphate + thiamine(in)"}
{"X":31777,"RHEA_ID":29812,"DIRECTION":"LR","MASTER_ID":29811,"ecocyc":"ABC-32-RXN","metacyc":"ABC-32-RXN","compounds":"ATP + H2O + thiamine(out) => ADP + H(+) + phosphate + thiamine(in)"}
{"X":31778,"RHEA_ID":29813,"compounds":"ADP + H(+) + phosphate + thiamine(in) => ATP + H2O + thiamine(out)"}
{"X":31779,"RHEA_ID":29814,"compounds":"ATP + H2O + thiamine(out) <=> ADP + H(+) + phosphate + thiamine(in)"}
{"X":31780,"RHEA_ID":29815,"compounds":"ATP + H2O + L-proline(out) = ADP + H(+) + L-proline(in) + phosphate"}
{"X":31781,"RHEA_ID":29816,"DIRECTION":"LR","MASTER_ID":29815,"ecocyc":"ABC-26-RXN","compounds":"ATP + H2O + L-proline(out) => ADP + H(+) + L-proline(in) + phosphate"}
{"X":31782,"RHEA_ID":29817,"compounds":"ADP + H(+) + L-proline(in) + phosphate => ATP + H2O + L-proline(out)"}
{"X":31783,"RHEA_ID":29818,"compounds":"ATP + H2O + L-proline(out) <=> ADP + H(+) + L-proline(in) + phosphate"}
{"X":31784,"RHEA_ID":29819,"compounds":"ATP + H2O + L-isoleucine(out) = ADP + H(+) + L-isoleucine(in) + phosphate"}
{"X":31785,"RHEA_ID":29820,"DIRECTION":"LR","MASTER_ID":29819,"ecocyc":"ABC-15-RXN","compounds":"ATP + H2O + L-isoleucine(out) => ADP + H(+) + L-isoleucine(in) + phosphate"}
{"X":31786,"RHEA_ID":29821,"compounds":"ADP + H(+) + L-isoleucine(in) + phosphate => ATP + H2O + L-isoleucine(out)"}
{"X":31787,"RHEA_ID":29822,"compounds":"ATP + H2O + L-isoleucine(out) <=> ADP + H(+) + L-isoleucine(in) + phosphate"}
{"X":31788,"RHEA_ID":29823,"compounds":"chloride(in) = chloride(out)"}
{"X":31789,"RHEA_ID":29824,"DIRECTION":"LR","MASTER_ID":29823,"reactome":"R-HSA-427570.1","compounds":"chloride(in) => chloride(out)"}
{"X":31790,"RHEA_ID":29824,"DIRECTION":"LR","MASTER_ID":29823,"reactome":"R-HSA-432036.4","compounds":"chloride(in) => chloride(out)"}
{"X":31791,"RHEA_ID":29824,"DIRECTION":"LR","MASTER_ID":29823,"reactome":"R-HSA-975340.3","compounds":"chloride(in) => chloride(out)"}
{"X":31792,"RHEA_ID":39783,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (17S,18R)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":31793,"RHEA_ID":29824,"DIRECTION":"LR","MASTER_ID":29823,"reactome":"R-HSA-975389.1","compounds":"chloride(in) => chloride(out)"}
{"X":31794,"RHEA_ID":29825,"DIRECTION":"RL","MASTER_ID":29823,"ecocyc":"TRANS-RXN-139","reactome":"R-HSA-2744361.3","compounds":"chloride(out) => chloride(in)"}
{"X":31795,"RHEA_ID":29825,"DIRECTION":"RL","MASTER_ID":29823,"ecocyc":"TRANS-RXN-139","reactome":"R-HSA-2744228.1","compounds":"chloride(out) => chloride(in)"}
{"X":31796,"RHEA_ID":39787,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":31797,"RHEA_ID":29825,"DIRECTION":"RL","MASTER_ID":29823,"ecocyc":"TRANS-RXN-139","reactome":"R-HSA-2744349.1","compounds":"chloride(out) => chloride(in)"}
{"X":31798,"RHEA_ID":29825,"DIRECTION":"RL","MASTER_ID":29823,"ecocyc":"TRANS-RXN-139","reactome":"R-HSA-8941543.1","compounds":"chloride(out) => chloride(in)"}
{"X":31799,"RHEA_ID":29825,"DIRECTION":"RL","MASTER_ID":29823,"ecocyc":"TRANS-RXN-139","reactome":"R-HSA-9659568.1","compounds":"chloride(out) => chloride(in)"}
{"X":31800,"RHEA_ID":39791,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":31801,"RHEA_ID":29826,"compounds":"chloride(in) <=> chloride(out)"}
{"X":31802,"RHEA_ID":29827,"compounds":"Mg(2+)(in) = Mg(2+)(out)"}
{"X":31803,"RHEA_ID":29828,"DIRECTION":"LR","MASTER_ID":29827,"reactome":"R-HSA-426223.1","compounds":"Mg(2+)(in) => Mg(2+)(out)"}
{"X":31804,"RHEA_ID":39795,"compounds":"7beta-hydroxycholesterol(in) + ATP + H2O = 7beta-hydroxycholesterol(out) + ADP + H(+) + phosphate"}
{"X":31805,"RHEA_ID":29828,"DIRECTION":"LR","MASTER_ID":29827,"reactome":"R-HSA-5336466.1","compounds":"Mg(2+)(in) => Mg(2+)(out)"}
{"X":31806,"RHEA_ID":29828,"DIRECTION":"LR","MASTER_ID":29827,"reactome":"R-HSA-5339528.1","compounds":"Mg(2+)(in) => Mg(2+)(out)"}
{"X":31807,"RHEA_ID":29828,"DIRECTION":"LR","MASTER_ID":29827,"reactome":"R-HSA-5336453.1","compounds":"Mg(2+)(in) => Mg(2+)(out)"}
{"X":31808,"RHEA_ID":39799,"compounds":"20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + NAD(+) = 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + NADH"}
{"X":31809,"RHEA_ID":29829,"DIRECTION":"RL","MASTER_ID":29827,"ecocyc":"TRANS-RXN-141","reactome":"R-HSA-5336454.1","compounds":"Mg(2+)(out) => Mg(2+)(in)"}
{"X":31810,"RHEA_ID":29830,"compounds":"Mg(2+)(in) <=> Mg(2+)(out)"}
{"X":31811,"RHEA_ID":29831,"compounds":"Ni(2+)(in) = Ni(2+)(out)"}
{"X":31812,"RHEA_ID":29832,"compounds":"Ni(2+)(in) => Ni(2+)(out)"}
{"X":31813,"RHEA_ID":29833,"DIRECTION":"RL","MASTER_ID":29831,"ecocyc":"TRANS-RXN-141B","compounds":"Ni(2+)(out) => Ni(2+)(in)"}
{"X":31814,"RHEA_ID":29834,"compounds":"Ni(2+)(in) <=> Ni(2+)(out)"}
{"X":31815,"RHEA_ID":29835,"compounds":"D-galactonate(in) + H(+)(in) = D-galactonate(out) + H(+)(out)"}
{"X":31816,"RHEA_ID":39807,"compounds":"octadecanoate(in) = octadecanoate(out)"}
{"X":31817,"RHEA_ID":29837,"DIRECTION":"RL","MASTER_ID":29835,"ecocyc":"TRANS-RXN-16","compounds":"D-galactonate(out) + H(+)(out) => D-galactonate(in) + H(+)(in)"}
{"X":31818,"RHEA_ID":29838,"compounds":"D-galactonate(in) + H(+)(in) <=> D-galactonate(out) + H(+)(out)"}
{"X":31819,"RHEA_ID":29839,"compounds":"2-dehydro-L-idonate + H(+) + NADPH = L-idonate + NADP(+)"}
{"X":31820,"RHEA_ID":29840,"DIRECTION":"LR","MASTER_ID":29839,"metacyc":"RXN-12106","compounds":"2-dehydro-L-idonate + H(+) + NADPH => L-idonate + NADP(+)"}
{"X":31821,"RHEA_ID":29841,"compounds":"L-idonate + NADP(+) => 2-dehydro-L-idonate + H(+) + NADPH"}
{"X":31822,"RHEA_ID":39813,"compounds":"18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":31823,"RHEA_ID":29843,"DIRECTION":"UN","MASTER_ID":29843,"ec":"6.2.1.13","compounds":"ATP + CoA + propanoate = ADP + phosphate + propanoyl-CoA"}
{"X":31824,"RHEA_ID":39815,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + octadecanoate = 2-hydroxyoctadecanoate + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":31825,"RHEA_ID":29845,"compounds":"ADP + phosphate + propanoyl-CoA => ATP + CoA + propanoate"}
{"X":31826,"RHEA_ID":39817,"compounds":"2-hydroxyoctadecanoate + 2 [Fe(III)-cytochrome b5] + H2O => 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + octadecanoate"}
{"X":31827,"RHEA_ID":29847,"compounds":"(2E)-tetradecenoyl-CoA = (3Z)-tetradecenoyl-CoA"}
{"X":31828,"RHEA_ID":39819,"compounds":"2 [Fe(II)-cytochrome b5] + docosanoate + 2 H(+) + O2 = 2-hydroxydocosanoate + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":31829,"RHEA_ID":29849,"compounds":"(3Z)-tetradecenoyl-CoA => (2E)-tetradecenoyl-CoA"}
{"X":31830,"RHEA_ID":29850,"compounds":"(2E)-tetradecenoyl-CoA <=> (3Z)-tetradecenoyl-CoA"}
{"X":31831,"RHEA_ID":29851,"compounds":"H2O + UDP-N-acetyl-alpha-D-galactosamine = 2 H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UMP"}
{"X":31832,"RHEA_ID":39823,"compounds":"2 [Fe(II)-cytochrome b5] + eicosanoate + 2 H(+) + O2 = 2-hydroxyeicosanoate + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":31833,"RHEA_ID":29853,"compounds":"2 H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UMP => H2O + UDP-N-acetyl-alpha-D-galactosamine"}
{"X":31834,"RHEA_ID":29854,"compounds":"H2O + UDP-N-acetyl-alpha-D-galactosamine <=> 2 H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UMP"}
{"X":31835,"RHEA_ID":29855,"compounds":"H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine = D-alanine + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate"}
{"X":31836,"RHEA_ID":39827,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + tetracosanoate = 2-hydroxytetracosanoate + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":31837,"RHEA_ID":29857,"compounds":"D-alanine + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate => H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine"}
{"X":31838,"RHEA_ID":29858,"DIRECTION":"BI","MASTER_ID":29855,"ecocyc":"RXN0-5227","metacyc":"RXN0-5227","compounds":"H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine <=> D-alanine + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate"}
{"X":31839,"RHEA_ID":29859,"compounds":"5'-deoxyadenosine + H2O = 5-deoxy-alpha-D-ribose + adenine"}
{"X":31840,"RHEA_ID":39831,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoate + O2 = 2-hydroxyhexadecanoate + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":31841,"RHEA_ID":29861,"compounds":"5-deoxy-alpha-D-ribose + adenine => 5'-deoxyadenosine + H2O"}
{"X":31842,"RHEA_ID":29862,"compounds":"5'-deoxyadenosine + H2O <=> 5-deoxy-alpha-D-ribose + adenine"}
{"X":31843,"RHEA_ID":29863,"compounds":"AMP + GTP = ADP + GDP"}
{"X":31844,"RHEA_ID":39835,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-(9Z-octadecenoyl)-sn-glycerol + phosphate"}
{"X":31845,"RHEA_ID":29865,"compounds":"ADP + GDP => AMP + GTP"}
{"X":31846,"RHEA_ID":29866,"compounds":"AMP + GTP <=> ADP + GDP"}
{"X":31847,"RHEA_ID":29867,"compounds":"AMP + ITP = ADP + IDP"}
{"X":31848,"RHEA_ID":39839,"compounds":"a 2,3-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA"}
{"X":31849,"RHEA_ID":29869,"compounds":"ADP + IDP => AMP + ITP"}
{"X":31850,"RHEA_ID":29870,"compounds":"AMP + ITP <=> ADP + IDP"}
{"X":31851,"RHEA_ID":29871,"DIRECTION":"UN","MASTER_ID":29871,"ec":"7.3.2.3","compounds":"ATP + H2O + thiosulfate(out) = ADP + H(+) + phosphate + thiosulfate(in)"}
{"X":31852,"RHEA_ID":39843,"compounds":"1,3-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA"}
{"X":31853,"RHEA_ID":29873,"compounds":"ADP + H(+) + phosphate + thiosulfate(in) => ATP + H2O + thiosulfate(out)"}
{"X":31854,"RHEA_ID":29874,"compounds":"ATP + H2O + thiosulfate(out) <=> ADP + H(+) + phosphate + thiosulfate(in)"}
{"X":31855,"RHEA_ID":29875,"DIRECTION":"UN","MASTER_ID":29875,"ec":"3.1.4.46","compounds":"H2O + sn-glycero-3-phospho-L-serine = H(+) + L-serine + sn-glycerol 3-phosphate"}
{"X":31856,"RHEA_ID":39847,"compounds":"a 2-acylglycerol + ATP = a 2-acyl-sn-glycerol 3-phosphate + ADP + H(+)"}
{"X":31857,"RHEA_ID":29877,"compounds":"H(+) + L-serine + sn-glycerol 3-phosphate => H2O + sn-glycero-3-phospho-L-serine"}
{"X":31858,"RHEA_ID":29878,"compounds":"H2O + sn-glycero-3-phospho-L-serine <=> H(+) + L-serine + sn-glycerol 3-phosphate"}
{"X":31859,"RHEA_ID":29879,"DIRECTION":"UN","MASTER_ID":29879,"ec":"7.4.2.1","compounds":"ATP + H2O + L-arginine(out) = ADP + H(+) + L-arginine(in) + phosphate"}
{"X":31860,"RHEA_ID":39851,"compounds":"2 a 1-acyl-sn-glycerol = a 1,2-diacyl-sn-glycerol + glycerol"}
{"X":31861,"RHEA_ID":29881,"compounds":"ADP + H(+) + L-arginine(in) + phosphate => ATP + H2O + L-arginine(out)"}
{"X":31862,"RHEA_ID":29882,"compounds":"ATP + H2O + L-arginine(out) <=> ADP + H(+) + L-arginine(in) + phosphate"}
{"X":31863,"RHEA_ID":29883,"DIRECTION":"UN","MASTER_ID":29883,"ec":"7.4.2.1","compounds":"ATP + H2O + L-ornithine(out) = ADP + H(+) + L-ornithine(in) + phosphate"}
{"X":31864,"RHEA_ID":29884,"DIRECTION":"LR","MASTER_ID":29883,"ecocyc":"ABC-37-RXN","metacyc":"ABC-37-RXN","compounds":"ATP + H2O + L-ornithine(out) => ADP + H(+) + L-ornithine(in) + phosphate"}
{"X":31865,"RHEA_ID":29885,"compounds":"ADP + H(+) + L-ornithine(in) + phosphate => ATP + H2O + L-ornithine(out)"}
{"X":31866,"RHEA_ID":29886,"compounds":"ATP + H2O + L-ornithine(out) <=> ADP + H(+) + L-ornithine(in) + phosphate"}
{"X":31867,"RHEA_ID":29887,"DIRECTION":"UN","MASTER_ID":29887,"ec":"7.4.2.1","compounds":"ATP + H2O + L-lysine(out) = ADP + H(+) + L-lysine(in) + phosphate"}
{"X":31868,"RHEA_ID":39859,"compounds":"1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycerol = a triacyl-sn-glycerol + glycerol"}
{"X":31869,"RHEA_ID":29889,"compounds":"ADP + H(+) + L-lysine(in) + phosphate => ATP + H2O + L-lysine(out)"}
{"X":31870,"RHEA_ID":29890,"compounds":"ATP + H2O + L-lysine(out) <=> ADP + H(+) + L-lysine(in) + phosphate"}
{"X":31871,"RHEA_ID":29891,"compounds":"ATP + H2O + L-histidine(out) = ADP + H(+) + L-histidine(in) + phosphate"}
{"X":31872,"RHEA_ID":39863,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol = 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine"}
{"X":31873,"RHEA_ID":29893,"compounds":"ADP + H(+) + L-histidine(in) + phosphate => ATP + H2O + L-histidine(out)"}
{"X":31874,"RHEA_ID":29894,"compounds":"ATP + H2O + L-histidine(out) <=> ADP + H(+) + L-histidine(in) + phosphate"}
{"X":31875,"RHEA_ID":29895,"compounds":"ATP + H2O + L-glutamine(out) = ADP + H(+) + L-glutamine(in) + phosphate"}
{"X":31876,"RHEA_ID":39871,"compounds":"3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine"}
{"X":31877,"RHEA_ID":29897,"compounds":"ADP + H(+) + L-glutamine(in) + phosphate => ATP + H2O + L-glutamine(out)"}
{"X":31878,"RHEA_ID":29898,"compounds":"ATP + H2O + L-glutamine(out) <=> ADP + H(+) + L-glutamine(in) + phosphate"}
{"X":31879,"RHEA_ID":29899,"DIRECTION":"UN","MASTER_ID":29899,"ec":"7.5.2.13","compounds":"ATP + D-xylose(out) + H2O = ADP + D-xylose(in) + H(+) + phosphate"}
{"X":31880,"RHEA_ID":39875,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol = a 1-acyl-sn-glycero-3-phosphocholine + a 2,3-diacyl-sn-glycerol"}
{"X":31881,"RHEA_ID":29900,"DIRECTION":"LR","MASTER_ID":29899,"ecocyc":"ABC-33-RXN","metacyc":"ABC-33-RXN","compounds":"ATP + D-xylose(out) + H2O => ADP + D-xylose(in) + H(+) + phosphate"}
{"X":31882,"RHEA_ID":29901,"compounds":"ADP + D-xylose(in) + H(+) + phosphate => ATP + D-xylose(out) + H2O"}
{"X":31883,"RHEA_ID":29902,"compounds":"ATP + D-xylose(out) + H2O <=> ADP + D-xylose(in) + H(+) + phosphate"}
{"X":31884,"RHEA_ID":39879,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol = a 1-acyl-sn-glycero-3-phosphoethanolamine + a 2,3-diacyl-sn-glycerol"}
{"X":31885,"RHEA_ID":29904,"DIRECTION":"LR","MASTER_ID":29903,"ecocyc":"ABC-28-RXN","metacyc":"ABC-28-RXN","compounds":"ATP + D-ribose(out) + H2O => ADP + D-ribose(in) + H(+) + phosphate"}
{"X":31886,"RHEA_ID":29905,"compounds":"ADP + D-ribose(in) + H(+) + phosphate => ATP + D-ribose(out) + H2O"}
{"X":31887,"RHEA_ID":29906,"compounds":"ATP + D-ribose(out) + H2O <=> ADP + D-ribose(in) + H(+) + phosphate"}
{"X":31888,"RHEA_ID":39883,"DIRECTION":"UN","MASTER_ID":39883,"ec":"1.1.1.364","compounds":"dTDP-6-deoxy-alpha-D-allose + NADP(+) = dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADPH"}
{"X":31889,"RHEA_ID":29908,"DIRECTION":"LR","MASTER_ID":29907,"ecocyc":"RXN-14073","metacyc":"RXN-14073","compounds":"H2O + sn-glycero-3-phospho-(1'-rac-glycerol) => glycerol + H(+) + sn-glycerol 3-phosphate"}
{"X":31890,"RHEA_ID":29909,"compounds":"glycerol + H(+) + sn-glycerol 3-phosphate => H2O + sn-glycero-3-phospho-(1'-rac-glycerol)"}
{"X":31891,"RHEA_ID":29910,"compounds":"H2O + sn-glycero-3-phospho-(1'-rac-glycerol) <=> glycerol + H(+) + sn-glycerol 3-phosphate"}
{"X":31892,"RHEA_ID":39887,"DIRECTION":"UN","MASTER_ID":39887,"ec":"1.14.15.33","compounds":"2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pikromycin"}
{"X":31893,"RHEA_ID":29912,"DIRECTION":"LR","MASTER_ID":29911,"ecocyc":"TRANS-RXN0-210","compounds":"ATP + H2O + N-acetyl-D-glucosamine(in) => ADP + H(+) + N-acetyl-D-glucosamine(out) + phosphate"}
{"X":31894,"RHEA_ID":29913,"compounds":"ADP + H(+) + N-acetyl-D-glucosamine(out) + phosphate => ATP + H2O + N-acetyl-D-glucosamine(in)"}
{"X":31895,"RHEA_ID":29914,"compounds":"ATP + H2O + N-acetyl-D-glucosamine(in) <=> ADP + H(+) + N-acetyl-D-glucosamine(out) + phosphate"}
{"X":31896,"RHEA_ID":39891,"DIRECTION":"UN","MASTER_ID":39891,"ec":"2.4.1.322","compounds":"devancoaminyl-vancomycin + dTDP-beta-L-vancosamine = dTDP + H(+) + vancomycin"}
{"X":31897,"RHEA_ID":29916,"DIRECTION":"LR","MASTER_ID":29915,"ecocyc":"RXN0-5120","metacyc":"RXN0-5120","compounds":"L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose => alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP"}
{"X":31898,"RHEA_ID":29917,"compounds":"alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP => L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose"}
{"X":31899,"RHEA_ID":29918,"compounds":"L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose <=> alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP"}
{"X":31900,"RHEA_ID":29919,"compounds":"alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP = ADP + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)"}
{"X":31901,"RHEA_ID":29920,"DIRECTION":"LR","MASTER_ID":29919,"ecocyc":"RXN0-5121","metacyc":"RXN0-5121","compounds":"alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP => ADP + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)"}
{"X":31902,"RHEA_ID":29921,"compounds":"ADP + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) => alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP"}
{"X":31903,"RHEA_ID":29922,"compounds":"alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP <=> ADP + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)"}
{"X":31904,"RHEA_ID":39899,"DIRECTION":"UN","MASTER_ID":39899,"ec":"2.4.1.324","compounds":"7-deoxyloganetin + UDP-alpha-D-glucose = 7-deoxyloganin + H(+) + UDP"}
{"X":31905,"RHEA_ID":29924,"DIRECTION":"LR","MASTER_ID":29923,"ecocyc":"RXN0-5122","metacyc":"RXN0-5122","compounds":"ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A => ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)"}
{"X":31906,"RHEA_ID":29925,"compounds":"ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) => ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A"}
{"X":31907,"RHEA_ID":29926,"compounds":"ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A <=> ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)"}
{"X":31908,"RHEA_ID":39903,"DIRECTION":"UN","MASTER_ID":39903,"ec":"2.5.1.119","metacyc":"RXN-15247","compounds":"isoxazolin-5-one + O-acetyl-L-serine = 3-(5-oxoisoxazolin-4-yl)-L-alanine + acetate + H(+)"}
{"X":31909,"RHEA_ID":29928,"compounds":"(R)-pantothenate(in) + Na(+)(in) => (R)-pantothenate(out) + Na(+)(out)"}
{"X":31910,"RHEA_ID":29929,"DIRECTION":"RL","MASTER_ID":29927,"ecocyc":"TRANS-RXN-117","compounds":"(R)-pantothenate(out) + Na(+)(out) => (R)-pantothenate(in) + Na(+)(in)"}
{"X":31911,"RHEA_ID":29930,"compounds":"(R)-pantothenate(in) + Na(+)(in) <=> (R)-pantothenate(out) + Na(+)(out)"}
{"X":31912,"RHEA_ID":39907,"DIRECTION":"UN","MASTER_ID":39907,"ec":"2.6.1.106","compounds":"2-oxoglutarate + dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose = dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + L-glutamate"}
{"X":31913,"RHEA_ID":29932,"DIRECTION":"LR","MASTER_ID":29931,"ecocyc":"RXN0-5123","metacyc":"RXN0-5123","compounds":"alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP => ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)"}
{"X":31914,"RHEA_ID":29933,"compounds":"ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) => alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP"}
{"X":31915,"RHEA_ID":29934,"compounds":"alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP <=> ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)"}
{"X":31916,"RHEA_ID":29935,"compounds":"cytosine(in) + H(+)(in) = cytosine(out) + H(+)(out)"}
{"X":31917,"RHEA_ID":29936,"compounds":"cytosine(in) + H(+)(in) => cytosine(out) + H(+)(out)"}
{"X":31918,"RHEA_ID":29937,"DIRECTION":"RL","MASTER_ID":29935,"ecocyc":"TRANS-RXN-116","compounds":"cytosine(out) + H(+)(out) => cytosine(in) + H(+)(in)"}
{"X":31919,"RHEA_ID":29938,"compounds":"cytosine(in) + H(+)(in) <=> cytosine(out) + H(+)(out)"}
{"X":31920,"RHEA_ID":39915,"compounds":"1-O-alkyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-sn-glycerol + phosphate"}
{"X":31921,"RHEA_ID":29940,"compounds":"H(+)(in) + phosphate(in) => H(+)(out) + phosphate(out)"}
{"X":31922,"RHEA_ID":29941,"DIRECTION":"RL","MASTER_ID":29939,"ecocyc":"TRANS-RXN-114","compounds":"H(+)(out) + phosphate(out) => H(+)(in) + phosphate(in)"}
{"X":31923,"RHEA_ID":29942,"compounds":"H(+)(in) + phosphate(in) <=> H(+)(out) + phosphate(out)"}
{"X":31924,"RHEA_ID":39919,"compounds":"1-O-(alk-1-enyl)-sn-glycero-3-phosphate + H2O = 1-O-(alk-1-enyl)-sn-glycerol + phosphate"}
{"X":31925,"RHEA_ID":29944,"compounds":"2-dehydro-3-deoxy-D-gluconate(in) + H(+)(in) => 2-dehydro-3-deoxy-D-gluconate(out) + H(+)(out)"}
{"X":31926,"RHEA_ID":29945,"DIRECTION":"RL","MASTER_ID":29943,"ecocyc":"TRANS-RXN-113","compounds":"2-dehydro-3-deoxy-D-gluconate(out) + H(+)(out) => 2-dehydro-3-deoxy-D-gluconate(in) + H(+)(in)"}
{"X":31927,"RHEA_ID":29946,"compounds":"2-dehydro-3-deoxy-D-gluconate(in) + H(+)(in) <=> 2-dehydro-3-deoxy-D-gluconate(out) + H(+)(out)"}
{"X":31928,"RHEA_ID":29947,"compounds":"H(+)(in) + L-rhamnopyranose(in) = H(+)(out) + L-rhamnopyranose(out)"}
{"X":31929,"RHEA_ID":29948,"compounds":"H(+)(in) + L-rhamnopyranose(in) => H(+)(out) + L-rhamnopyranose(out)"}
{"X":31930,"RHEA_ID":29949,"DIRECTION":"RL","MASTER_ID":29947,"ecocyc":"TRANS-RXN-112","metacyc":"TRANS-RXN-112","compounds":"H(+)(out) + L-rhamnopyranose(out) => H(+)(in) + L-rhamnopyranose(in)"}
{"X":31931,"RHEA_ID":29950,"compounds":"H(+)(in) + L-rhamnopyranose(in) <=> H(+)(out) + L-rhamnopyranose(out)"}
{"X":31932,"RHEA_ID":39927,"compounds":"1-O-alkyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)"}
{"X":31933,"RHEA_ID":29952,"compounds":"H(+)(in) + uridine(in) => H(+)(out) + uridine(out)"}
{"X":31934,"RHEA_ID":29953,"DIRECTION":"RL","MASTER_ID":29951,"ecocyc":"TRANS-RXN-108I","compounds":"H(+)(out) + uridine(out) => H(+)(in) + uridine(in)"}
{"X":31935,"RHEA_ID":29954,"compounds":"H(+)(in) + uridine(in) <=> H(+)(out) + uridine(out)"}
{"X":31936,"RHEA_ID":39931,"compounds":"1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H(+)"}
{"X":31937,"RHEA_ID":29956,"compounds":"H(+)(in) + thymidine(in) => H(+)(out) + thymidine(out)"}
{"X":31938,"RHEA_ID":29957,"DIRECTION":"RL","MASTER_ID":29955,"ecocyc":"TRANS-RXN-108H","compounds":"H(+)(out) + thymidine(out) => H(+)(in) + thymidine(in)"}
{"X":31939,"RHEA_ID":29958,"compounds":"H(+)(in) + thymidine(in) <=> H(+)(out) + thymidine(out)"}
{"X":31940,"RHEA_ID":39935,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)"}
{"X":31941,"RHEA_ID":29960,"DIRECTION":"LR","MASTER_ID":29959,"ecocyc":"RXN0-5124","metacyc":"RXN0-5124","compounds":"alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-galactose => alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP"}
{"X":31942,"RHEA_ID":29961,"compounds":"alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP => alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-galactose"}
{"X":31943,"RHEA_ID":29962,"compounds":"alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-galactose <=> alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP"}
{"X":31944,"RHEA_ID":29963,"compounds":"H(+)(in) + inosine(in) = H(+)(out) + inosine(out)"}
{"X":31945,"RHEA_ID":29964,"compounds":"H(+)(in) + inosine(in) => H(+)(out) + inosine(out)"}
{"X":31946,"RHEA_ID":29965,"DIRECTION":"RL","MASTER_ID":29963,"ecocyc":"TRANS-RXN-108G","compounds":"H(+)(out) + inosine(out) => H(+)(in) + inosine(in)"}
{"X":31947,"RHEA_ID":29966,"compounds":"H(+)(in) + inosine(in) <=> H(+)(out) + inosine(out)"}
{"X":31948,"RHEA_ID":39943,"compounds":"a 1-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA"}
{"X":31949,"RHEA_ID":29968,"compounds":"2'-deoxyuridine(in) + H(+)(in) => 2'-deoxyuridine(out) + H(+)(out)"}
{"X":31950,"RHEA_ID":29969,"DIRECTION":"RL","MASTER_ID":29967,"ecocyc":"TRANS-RXN-108F","compounds":"2'-deoxyuridine(out) + H(+)(out) => 2'-deoxyuridine(in) + H(+)(in)"}
{"X":31951,"RHEA_ID":29970,"compounds":"2'-deoxyuridine(in) + H(+)(in) <=> 2'-deoxyuridine(out) + H(+)(out)"}
{"X":31952,"RHEA_ID":39947,"compounds":"1,3-diacyl-sn-glycerol + H2O = a fatty acid + a monoacylglycerol + H(+)"}
{"X":31953,"RHEA_ID":29972,"compounds":"2'-deoxyinosine(in) + H(+)(in) => 2'-deoxyinosine(out) + H(+)(out)"}
{"X":31954,"RHEA_ID":29973,"DIRECTION":"RL","MASTER_ID":29971,"ecocyc":"TRANS-RXN-108E","compounds":"2'-deoxyinosine(out) + H(+)(out) => 2'-deoxyinosine(in) + H(+)(in)"}
{"X":31955,"RHEA_ID":29974,"compounds":"2'-deoxyinosine(in) + H(+)(in) <=> 2'-deoxyinosine(out) + H(+)(out)"}
{"X":31956,"RHEA_ID":39951,"compounds":"(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-glycerol + CoA"}
{"X":31957,"RHEA_ID":29976,"compounds":"2'-deoxycytidine(in) + H(+)(in) => 2'-deoxycytidine(out) + H(+)(out)"}
{"X":31958,"RHEA_ID":29977,"DIRECTION":"RL","MASTER_ID":29975,"ecocyc":"TRANS-RXN-108D","compounds":"2'-deoxycytidine(out) + H(+)(out) => 2'-deoxycytidine(in) + H(+)(in)"}
{"X":31959,"RHEA_ID":29978,"compounds":"2'-deoxycytidine(in) + H(+)(in) <=> 2'-deoxycytidine(out) + H(+)(out)"}
{"X":31960,"RHEA_ID":39955,"compounds":"(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+)"}
{"X":31961,"RHEA_ID":29980,"compounds":"2'-deoxyadenosine(in) + H(+)(in) => 2'-deoxyadenosine(out) + H(+)(out)"}
{"X":31962,"RHEA_ID":29981,"DIRECTION":"RL","MASTER_ID":29979,"ecocyc":"TRANS-RXN-108C","compounds":"2'-deoxyadenosine(out) + H(+)(out) => 2'-deoxyadenosine(in) + H(+)(in)"}
{"X":31963,"RHEA_ID":29982,"compounds":"2'-deoxyadenosine(in) + H(+)(in) <=> 2'-deoxyadenosine(out) + H(+)(out)"}
{"X":31964,"RHEA_ID":39959,"compounds":"1-hexadecanoylglycerol + H2O = glycerol + H(+) + hexadecanoate"}
{"X":31965,"RHEA_ID":29984,"compounds":"cytidine(in) + H(+)(in) => cytidine(out) + H(+)(out)"}
{"X":31966,"RHEA_ID":29985,"DIRECTION":"RL","MASTER_ID":29983,"ecocyc":"TRANS-RXN-108B","compounds":"cytidine(out) + H(+)(out) => cytidine(in) + H(+)(in)"}
{"X":31967,"RHEA_ID":29986,"compounds":"cytidine(in) + H(+)(in) <=> cytidine(out) + H(+)(out)"}
{"X":31968,"RHEA_ID":39963,"compounds":"2-hexadecanoylglycerol + H2O = glycerol + H(+) + hexadecanoate"}
{"X":31969,"RHEA_ID":29988,"compounds":"adenosine(in) + H(+)(in) => adenosine(out) + H(+)(out)"}
{"X":31970,"RHEA_ID":29989,"DIRECTION":"RL","MASTER_ID":29987,"ecocyc":"TRANS-RXN-108A","compounds":"adenosine(out) + H(+)(out) => adenosine(in) + H(+)(in)"}
{"X":31971,"RHEA_ID":29990,"compounds":"adenosine(in) + H(+)(in) <=> adenosine(out) + H(+)(out)"}
{"X":31972,"RHEA_ID":39967,"compounds":"2-aminobut-2-enoate = 2-iminobutanoate"}
{"X":31973,"RHEA_ID":29992,"compounds":"H(+)(in) + L-lyxose(in) => H(+)(out) + L-lyxose(out)"}
{"X":31974,"RHEA_ID":29993,"DIRECTION":"RL","MASTER_ID":29991,"ecocyc":"TRANS-RXN0-236","compounds":"H(+)(out) + L-lyxose(out) => H(+)(in) + L-lyxose(in)"}
{"X":31975,"RHEA_ID":29994,"compounds":"H(+)(in) + L-lyxose(in) <=> H(+)(out) + L-lyxose(out)"}
{"X":31976,"RHEA_ID":29995,"DIRECTION":"UN","MASTER_ID":29995,"ec":"7.6.2.16","compounds":"ATP + H2O + putrescine(out) = ADP + H(+) + phosphate + putrescine(in)"}
{"X":31977,"RHEA_ID":29996,"DIRECTION":"LR","MASTER_ID":29995,"ecocyc":"ABC-25-RXN","metacyc":"ABC-25-RXN","compounds":"ATP + H2O + putrescine(out) => ADP + H(+) + phosphate + putrescine(in)"}
{"X":31978,"RHEA_ID":39973,"compounds":"2-aminobut-2-enoate => 1-aminocyclopropane-1-carboxylate"}
{"X":31979,"RHEA_ID":29998,"compounds":"ATP + H2O + putrescine(out) <=> ADP + H(+) + phosphate + putrescine(in)"}
{"X":31980,"RHEA_ID":29999,"compounds":"ATP + H2O + spermidine(out) = ADP + H(+) + phosphate + spermidine(in)"}
{"X":31981,"RHEA_ID":30000,"DIRECTION":"LR","MASTER_ID":29999,"ecocyc":"ABC-24-RXN","compounds":"ATP + H2O + spermidine(out) => ADP + H(+) + phosphate + spermidine(in)"}
{"X":31982,"RHEA_ID":39977,"compounds":"2-oxobutanoate + NH4(+) => 2-iminobutanoate + H2O"}
{"X":31983,"RHEA_ID":30002,"compounds":"ATP + H2O + spermidine(out) <=> ADP + H(+) + phosphate + spermidine(in)"}
{"X":31984,"RHEA_ID":30003,"compounds":"alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose = alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP"}
{"X":31985,"RHEA_ID":30004,"DIRECTION":"LR","MASTER_ID":30003,"ecocyc":"RXN0-5125","metacyc":"RXN0-5125","compounds":"alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose => alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP"}
{"X":31986,"RHEA_ID":30005,"compounds":"alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP => alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose"}
{"X":31987,"RHEA_ID":30006,"compounds":"alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose <=> alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP"}
{"X":31988,"RHEA_ID":30007,"DIRECTION":"UN","MASTER_ID":30007,"ec":"7.5.2.12","compounds":"ATP + H2O + L-arabinose(out) = ADP + H(+) + L-arabinose(in) + phosphate"}
{"X":31989,"RHEA_ID":30007,"DIRECTION":"UN","MASTER_ID":30007,"ec":"7.5.2.13","compounds":"ATP + H2O + L-arabinose(out) = ADP + H(+) + L-arabinose(in) + phosphate"}
{"X":31990,"RHEA_ID":30008,"DIRECTION":"LR","MASTER_ID":30007,"ecocyc":"ABC-2-RXN","metacyc":"ABC-2-RXN","compounds":"ATP + H2O + L-arabinose(out) => ADP + H(+) + L-arabinose(in) + phosphate"}
{"X":31991,"RHEA_ID":30009,"compounds":"ADP + H(+) + L-arabinose(in) + phosphate => ATP + H2O + L-arabinose(out)"}
{"X":31992,"RHEA_ID":30010,"compounds":"ATP + H2O + L-arabinose(out) <=> ADP + H(+) + L-arabinose(in) + phosphate"}
{"X":31993,"RHEA_ID":30011,"compounds":"ATP + beta-D-galactose(out) + H2O = ADP + beta-D-galactose(in) + H(+) + phosphate"}
{"X":31994,"RHEA_ID":30012,"DIRECTION":"LR","MASTER_ID":30011,"ecocyc":"ABC-18-RXN","metacyc":"ABC-18-RXN","compounds":"ATP + beta-D-galactose(out) + H2O => ADP + beta-D-galactose(in) + H(+) + phosphate"}
{"X":31995,"RHEA_ID":30013,"compounds":"ADP + beta-D-galactose(in) + H(+) + phosphate => ATP + beta-D-galactose(out) + H2O"}
{"X":31996,"RHEA_ID":30014,"compounds":"ATP + beta-D-galactose(out) + H2O <=> ADP + beta-D-galactose(in) + H(+) + phosphate"}
{"X":31997,"RHEA_ID":30015,"compounds":"alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose = alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP"}
{"X":31998,"RHEA_ID":39993,"compounds":"CoA + H(+) + N-acyl-4-hydroxyeicosasphinganine => (4R)-hydroxyeicosasphinganine + an acyl-CoA"}
{"X":31999,"RHEA_ID":30017,"compounds":"alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP => alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose"}
{"X":32000,"RHEA_ID":30018,"compounds":"alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose <=> alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP"}
{"X":32001,"RHEA_ID":30019,"compounds":"ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A = ADP + H(+) + lipid A-core"}
{"X":32002,"RHEA_ID":30020,"DIRECTION":"LR","MASTER_ID":30019,"ecocyc":"RXN0-5127","metacyc":"RXN0-5127","compounds":"ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A => ADP + H(+) + lipid A-core"}
{"X":32003,"RHEA_ID":30021,"compounds":"ADP + H(+) + lipid A-core => ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A"}
{"X":32004,"RHEA_ID":39999,"compounds":"a sphingoid 1-phosphate = a fatty aldehyde + phosphoethanolamine"}
{"X":32005,"RHEA_ID":30023,"compounds":"L-alanine + pyridoxal 5'-phosphate = pyridoxamine 5'-phosphate + pyruvate"}
{"X":32006,"RHEA_ID":30024,"compounds":"L-alanine + pyridoxal 5'-phosphate => pyridoxamine 5'-phosphate + pyruvate"}
{"X":32007,"RHEA_ID":30025,"compounds":"pyridoxamine 5'-phosphate + pyruvate => L-alanine + pyridoxal 5'-phosphate"}
{"X":32008,"RHEA_ID":40003,"compounds":"ent-copalyl diphosphate = (Z)-biformene + diphosphate"}
{"X":32009,"RHEA_ID":30027,"compounds":"D-glyceraldehyde + H(+) + NADH = glycerol + NAD(+)"}
{"X":32010,"RHEA_ID":30028,"DIRECTION":"LR","MASTER_ID":30027,"metacyc":"RXN-11709","compounds":"D-glyceraldehyde + H(+) + NADH => glycerol + NAD(+)"}
{"X":32011,"RHEA_ID":30029,"compounds":"glycerol + NAD(+) => D-glyceraldehyde + H(+) + NADH"}
{"X":32012,"RHEA_ID":40007,"compounds":"(+)-copalyl diphosphate + H2O = (+)-copalol + diphosphate"}
{"X":32013,"RHEA_ID":30031,"DIRECTION":"UN","MASTER_ID":30031,"ec":"5.5.1.1","compounds":"(S)-muconolactone = cis,cis-muconate + H(+)"}
{"X":32014,"RHEA_ID":30032,"compounds":"(S)-muconolactone => cis,cis-muconate + H(+)"}
{"X":32015,"RHEA_ID":30033,"DIRECTION":"RL","MASTER_ID":30031,"metacyc":"MUCONATE-CYCLOISOMERASE-RXN","compounds":"cis,cis-muconate + H(+) => (S)-muconolactone"}
{"X":32016,"RHEA_ID":40011,"compounds":"(+)-copalyl diphosphate + H2O = diphosphate + manool"}
{"X":32017,"RHEA_ID":30035,"compounds":"3,4-dihydroxybenzoate + 2 H(+) + NADH + O2 = benzene-1,2,4-triol + CO2 + H2O + NAD(+)"}
{"X":32018,"RHEA_ID":30036,"compounds":"3,4-dihydroxybenzoate + 2 H(+) + NADH + O2 => benzene-1,2,4-triol + CO2 + H2O + NAD(+)"}
{"X":32019,"RHEA_ID":30037,"compounds":"benzene-1,2,4-triol + CO2 + H2O + NAD(+) => 3,4-dihydroxybenzoate + 2 H(+) + NADH + O2"}
{"X":32020,"RHEA_ID":49988,"DIRECTION":"UN","MASTER_ID":49988,"ec":"1.14.13.226","compounds":"acetone + H(+) + NADPH + O2 = H2O + methyl acetate + NADP(+)"}
{"X":32021,"RHEA_ID":30039,"compounds":"3,4-dihydroxybenzoate + 2 H(+) + NADPH + O2 = benzene-1,2,4-triol + CO2 + H2O + NADP(+)"}
{"X":32022,"RHEA_ID":30040,"compounds":"3,4-dihydroxybenzoate + 2 H(+) + NADPH + O2 => benzene-1,2,4-triol + CO2 + H2O + NADP(+)"}
{"X":32023,"RHEA_ID":30041,"compounds":"benzene-1,2,4-triol + CO2 + H2O + NADP(+) => 3,4-dihydroxybenzoate + 2 H(+) + NADPH + O2"}
{"X":32024,"RHEA_ID":40019,"compounds":"ent-copalyl diphosphate + H2O = (-)-ent-copalol + diphosphate"}
{"X":32025,"RHEA_ID":30043,"compounds":"fumarate + L-aspartate = iminosuccinate + succinate"}
{"X":32026,"RHEA_ID":30044,"DIRECTION":"LR","MASTER_ID":30043,"ecocyc":"RXN-9772","metacyc":"RXN-9772","compounds":"fumarate + L-aspartate => iminosuccinate + succinate"}
{"X":32027,"RHEA_ID":30045,"compounds":"iminosuccinate + succinate => fumarate + L-aspartate"}
{"X":32028,"RHEA_ID":40023,"compounds":"9alpha-copalyl diphosphate + H2O = diphosphate + syn-copalol"}
{"X":32029,"RHEA_ID":30047,"compounds":"chloroacetaldehyde + H2O + NAD(+) = chloroacetate + 2 H(+) + NADH"}
{"X":32030,"RHEA_ID":30048,"compounds":"chloroacetaldehyde + H2O + NAD(+) => chloroacetate + 2 H(+) + NADH"}
{"X":32031,"RHEA_ID":30049,"compounds":"chloroacetate + 2 H(+) + NADH => chloroacetaldehyde + H2O + NAD(+)"}
{"X":32032,"RHEA_ID":40027,"compounds":"9alpha-copalyl diphosphate + H2O = (13S)-vitexifolin A + diphosphate"}
{"X":32033,"RHEA_ID":30051,"DIRECTION":"UN","MASTER_ID":30051,"ec":"3.8.1.3","compounds":"fluoroacetate + H2O = fluoride + glycolate + H(+)"}
{"X":32034,"RHEA_ID":30052,"DIRECTION":"LR","MASTER_ID":30051,"metacyc":"RXN-11761","compounds":"fluoroacetate + H2O => fluoride + glycolate + H(+)"}
{"X":32035,"RHEA_ID":30053,"compounds":"fluoride + glycolate + H(+) => fluoroacetate + H2O"}
{"X":32036,"RHEA_ID":40031,"compounds":"ent-copalyl diphosphate + H2O = diphosphate + ent-manool"}
{"X":32037,"RHEA_ID":30055,"compounds":"L-allo-threonine + NADP(+) = (2S)-2-amino-3-oxobutanoate + H(+) + NADPH"}
{"X":32038,"RHEA_ID":30056,"DIRECTION":"LR","MASTER_ID":30055,"ecocyc":"RXN-16000","metacyc":"RXN-16000","compounds":"L-allo-threonine + NADP(+) => (2S)-2-amino-3-oxobutanoate + H(+) + NADPH"}
{"X":32039,"RHEA_ID":30057,"compounds":"(2S)-2-amino-3-oxobutanoate + H(+) + NADPH => L-allo-threonine + NADP(+)"}
{"X":32040,"RHEA_ID":50008,"DIRECTION":"UN","MASTER_ID":50008,"ec":"1.14.13.232","compounds":"6-methylpretetramide + 2 H(+) + NADPH + O2 = 4-hydroxy-6-methylpretetramide + H2O + NADP(+)"}
{"X":32041,"RHEA_ID":30059,"DIRECTION":"UN","MASTER_ID":30059,"ec":"1.3.98.1","compounds":"(S)-dihydroorotate + fumarate = orotate + succinate"}
{"X":32042,"RHEA_ID":30060,"DIRECTION":"LR","MASTER_ID":30059,"metacyc":"RXN-9929","compounds":"(S)-dihydroorotate + fumarate => orotate + succinate"}
{"X":32043,"RHEA_ID":30061,"compounds":"orotate + succinate => (S)-dihydroorotate + fumarate"}
{"X":32044,"RHEA_ID":40039,"DIRECTION":"UN","MASTER_ID":40039,"ec":"6.3.2.42","compounds":"2 ATP + 2 L-glutamate + N-acetyl-L-aspartate = 2 ADP + 2 H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate + 2 phosphate"}
{"X":32045,"RHEA_ID":30063,"DIRECTION":"UN","MASTER_ID":30063,"ec":"2.1.1.163","compounds":"2-demethylmenaquinol-8 + S-adenosyl-L-methionine = H(+) + menaquinol-8 + S-adenosyl-L-homocysteine"}
{"X":32046,"RHEA_ID":30064,"DIRECTION":"LR","MASTER_ID":30063,"ecocyc":"ADOMET-DMK-METHYLTRANSFER-RXN","metacyc":"ADOMET-DMK-METHYLTRANSFER-RXN","compounds":"2-demethylmenaquinol-8 + S-adenosyl-L-methionine => H(+) + menaquinol-8 + S-adenosyl-L-homocysteine"}
{"X":32047,"RHEA_ID":30065,"compounds":"H(+) + menaquinol-8 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-8 + S-adenosyl-L-methionine"}
{"X":32048,"RHEA_ID":40043,"DIRECTION":"UN","MASTER_ID":40043,"ec":"6.3.1.17","compounds":"ATP + citrate + L-glutamate = ADP + beta-citrylglutamate + H(+) + phosphate"}
{"X":32049,"RHEA_ID":30067,"compounds":"betaine aldehyde + H2O + NADP(+) = betaine + 2 H(+) + NADPH"}
{"X":32050,"RHEA_ID":30068,"compounds":"betaine aldehyde + H2O + NADP(+) => betaine + 2 H(+) + NADPH"}
{"X":32051,"RHEA_ID":30069,"compounds":"betaine + 2 H(+) + NADPH => betaine aldehyde + H2O + NADP(+)"}
{"X":32052,"RHEA_ID":40047,"compounds":"1,2,3-trioctanoylglycerol + H2O = 1,2-dioctanoyl-sn-glycerol + H(+) + octanoate"}
{"X":32053,"RHEA_ID":40048,"compounds":"1,2,3-trioctanoylglycerol + H2O => 1,2-dioctanoyl-sn-glycerol + H(+) + octanoate"}
{"X":32054,"RHEA_ID":30072,"compounds":"acetyl-CoA + butanoate => acetate + butanoyl-CoA"}
{"X":32055,"RHEA_ID":30073,"compounds":"acetate + butanoyl-CoA => acetyl-CoA + butanoate"}
{"X":32056,"RHEA_ID":40051,"DIRECTION":"UN","MASTER_ID":40051,"ec":"4.2.1.151","compounds":"chorismate = 3-[(1-carboxyvinyl)-oxy]benzoate + H2O"}
{"X":32057,"RHEA_ID":40052,"DIRECTION":"LR","MASTER_ID":40051,"metacyc":"RXN-12345","compounds":"chorismate => 3-[(1-carboxyvinyl)-oxy]benzoate + H2O"}
{"X":32058,"RHEA_ID":30076,"DIRECTION":"LR","MASTER_ID":30075,"metacyc":"RXN-14065","compounds":"CMP + H2O => cytosine + D-ribose 5-phosphate"}
{"X":32059,"RHEA_ID":30077,"compounds":"cytosine + D-ribose 5-phosphate => CMP + H2O"}
{"X":32060,"RHEA_ID":40055,"compounds":"1,2,3-trioctanoylglycerol + H2O = 2,3-dioctanoyl-sn-glycerol + H(+) + octanoate"}
{"X":32061,"RHEA_ID":40056,"compounds":"1,2,3-trioctanoylglycerol + H2O => 2,3-dioctanoyl-sn-glycerol + H(+) + octanoate"}
{"X":32062,"RHEA_ID":30080,"compounds":"ATP + CoA + crotonobetaine => AMP + crotonobetainyl-CoA + diphosphate"}
{"X":32063,"RHEA_ID":30081,"compounds":"AMP + crotonobetainyl-CoA + diphosphate => ATP + CoA + crotonobetaine"}
{"X":32064,"RHEA_ID":30082,"DIRECTION":"BI","MASTER_ID":30079,"metacyc":"CROTCOALIG-RXN","compounds":"ATP + CoA + crotonobetaine <=> AMP + crotonobetainyl-CoA + diphosphate"}
{"X":32065,"RHEA_ID":40060,"compounds":"decanoyl-CoA + H2O => CoA + decanoate + H(+)"}
{"X":32066,"RHEA_ID":30084,"DIRECTION":"LR","MASTER_ID":30083,"ecocyc":"RXN0-2945","compounds":"4 Cu(+) + 4 H(+) + O2 => 4 Cu(2+) + 2 H2O"}
{"X":32067,"RHEA_ID":30085,"compounds":"4 Cu(2+) + 2 H2O => 4 Cu(+) + 4 H(+) + O2"}
{"X":32068,"RHEA_ID":30086,"compounds":"4 Cu(+) + 4 H(+) + O2 <=> 4 Cu(2+) + 2 H2O"}
{"X":32069,"RHEA_ID":40064,"compounds":"6-oxocyclohex-1-ene-1-carbonyl-CoA + H2O => 2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA"}
{"X":32070,"RHEA_ID":30088,"DIRECTION":"LR","MASTER_ID":30087,"reactome":"R-HSA-880050.2","compounds":"(S)-2-hydroxyglutarate + FAD + H(+) => 2-oxoglutarate + FADH2"}
{"X":32071,"RHEA_ID":30089,"compounds":"2-oxoglutarate + FADH2 => (S)-2-hydroxyglutarate + FAD + H(+)"}
{"X":32072,"RHEA_ID":30090,"compounds":"(S)-2-hydroxyglutarate + FAD + H(+) <=> 2-oxoglutarate + FADH2"}
{"X":32073,"RHEA_ID":40068,"compounds":"2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA + H2O => 3-hydroxy-6-carboxyhexanoyl-CoA + H(+)"}
{"X":32074,"RHEA_ID":30092,"compounds":"a ubiquinone + D-alanine + H2O => a ubiquinol + NH4(+) + pyruvate"}
{"X":32075,"RHEA_ID":30093,"compounds":"a ubiquinol + NH4(+) + pyruvate => a ubiquinone + D-alanine + H2O"}
{"X":32076,"RHEA_ID":30094,"DIRECTION":"BI","MASTER_ID":30091,"ecocyc":"DALADEHYDROG-RXN","metacyc":"DALADEHYDROG-RXN","compounds":"a ubiquinone + D-alanine + H2O <=> a ubiquinol + NH4(+) + pyruvate"}
{"X":32077,"RHEA_ID":40072,"DIRECTION":"LR","MASTER_ID":40071,"metacyc":"RXN-15127","compounds":"2-aminoprop-2-enoate + H2O => NH4(+) + pyruvate"}
{"X":32078,"RHEA_ID":30096,"DIRECTION":"LR","MASTER_ID":30095,"metacyc":"RXNI-3","compounds":"(S)-malate + a menaquinone => a menaquinol + oxaloacetate"}
{"X":32079,"RHEA_ID":30097,"compounds":"a menaquinol + oxaloacetate => (S)-malate + a menaquinone"}
{"X":32080,"RHEA_ID":30098,"compounds":"(S)-malate + a menaquinone <=> a menaquinol + oxaloacetate"}
{"X":32081,"RHEA_ID":40076,"DIRECTION":"LR","MASTER_ID":40075,"metacyc":"RXN-14910","compounds":"6-amino-6-deoxyfutalosine + H(+) + H2O => futalosine + NH4(+)"}
{"X":32082,"RHEA_ID":30100,"DIRECTION":"LR","MASTER_ID":30099,"ecocyc":"DMK-RXN","metacyc":"DMK-RXN","compounds":"1,4-dihydroxy-2-naphthoate + all-trans-octaprenyl diphosphate + H(+) => 2-demethylmenaquinol-8 + CO2 + diphosphate"}
{"X":32083,"RHEA_ID":30101,"compounds":"2-demethylmenaquinol-8 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-octaprenyl diphosphate + H(+)"}
{"X":32084,"RHEA_ID":40080,"compounds":"docosanoate + O2 + reduced [NADPH--hemoprotein reductase] => 22-hydroxydocosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":32085,"RHEA_ID":30104,"compounds":"2,5-didehydro-D-gluconate + H(+) + NADH => 5-dehydro-D-gluconate + NAD(+)"}
{"X":32086,"RHEA_ID":30105,"compounds":"5-dehydro-D-gluconate + NAD(+) => 2,5-didehydro-D-gluconate + H(+) + NADH"}
{"X":32087,"RHEA_ID":30106,"compounds":"2,5-didehydro-D-gluconate + H(+) + NADH <=> 5-dehydro-D-gluconate + NAD(+)"}
{"X":32088,"RHEA_ID":40084,"compounds":"hexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] => 26-hydroxyhexacosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":32089,"RHEA_ID":30108,"compounds":"D-serine + NADP(+) => 2-aminomalonate semialdehyde + H(+) + NADPH"}
{"X":32090,"RHEA_ID":30109,"compounds":"2-aminomalonate semialdehyde + H(+) + NADPH => D-serine + NADP(+)"}
{"X":32091,"RHEA_ID":30110,"compounds":"D-serine + NADP(+) <=> 2-aminomalonate semialdehyde + H(+) + NADPH"}
{"X":32092,"RHEA_ID":40088,"compounds":"22-hydroxydocosanoate + NAD(+) => 22-oxodocosanoate + H(+) + NADH"}
{"X":32093,"RHEA_ID":30112,"DIRECTION":"LR","MASTER_ID":30111,"ecocyc":"RXN-20025","metacyc":"RXN-20025","compounds":"Fe(III)-enterobactin + H(+) + 3 H2O => Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + 2 N-(2,3-dihydroxybenzoyl)-L-serine"}
{"X":32094,"RHEA_ID":30113,"compounds":"Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + 2 N-(2,3-dihydroxybenzoyl)-L-serine => Fe(III)-enterobactin + H(+) + 3 H2O"}
{"X":32095,"RHEA_ID":30114,"compounds":"Fe(III)-enterobactin + H(+) + 3 H2O <=> Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + 2 N-(2,3-dihydroxybenzoyl)-L-serine"}
{"X":32096,"RHEA_ID":40092,"compounds":"26-hydroxyhexacosanoate + NAD(+) => 26-oxohexacosanoate + H(+) + NADH"}
{"X":32097,"RHEA_ID":30116,"compounds":"decanoyl-[ACP] + H2O => decanoate + H(+) + holo-[ACP]"}
{"X":32098,"RHEA_ID":30117,"compounds":"decanoate + H(+) + holo-[ACP] => decanoyl-[ACP] + H2O"}
{"X":32099,"RHEA_ID":40096,"compounds":"26-oxohexacosanoate + H2O + NAD(+) => 2 H(+) + hexacosanedioate + NADH"}
{"X":32100,"RHEA_ID":30120,"DIRECTION":"LR","MASTER_ID":30119,"ecocyc":"3.1.2.21-RXN","metacyc":"3.1.2.21-RXN","compounds":"dodecanoyl-[ACP] + H2O => dodecanoate + H(+) + holo-[ACP]"}
{"X":32101,"RHEA_ID":30121,"compounds":"dodecanoate + H(+) + holo-[ACP] => dodecanoyl-[ACP] + H2O"}
{"X":32102,"RHEA_ID":40100,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA => 1-(9Z-octadecenoyl)-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":32103,"RHEA_ID":30124,"DIRECTION":"LR","MASTER_ID":30123,"metacyc":"RXN-10727","compounds":"H2O + tetradecanoyl-[ACP] => H(+) + holo-[ACP] + tetradecanoate"}
{"X":32104,"RHEA_ID":30125,"compounds":"H(+) + holo-[ACP] + tetradecanoate => H2O + tetradecanoyl-[ACP]"}
{"X":32105,"RHEA_ID":40104,"compounds":"H2O + propanoyl-CoA => CoA + H(+) + propanoate"}
{"X":32106,"RHEA_ID":30132,"compounds":"H2O + octanoyl-[ACP] => H(+) + holo-[ACP] + octanoate"}
{"X":32107,"RHEA_ID":30133,"compounds":"H(+) + holo-[ACP] + octanoate => H2O + octanoyl-[ACP]"}
{"X":32108,"RHEA_ID":40108,"compounds":"1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA => 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":32109,"RHEA_ID":30136,"DIRECTION":"LR","MASTER_ID":30135,"metacyc":"RXN-9627","compounds":"dodecanoyl-CoA + H2O => CoA + dodecanoate + H(+)"}
{"X":32110,"RHEA_ID":30137,"compounds":"CoA + dodecanoate + H(+) => dodecanoyl-CoA + H2O"}
{"X":32111,"RHEA_ID":30138,"compounds":"dodecanoyl-CoA + H2O <=> CoA + dodecanoate + H(+)"}
{"X":32112,"RHEA_ID":40112,"compounds":"butanoyl-CoA + H2O => butanoate + CoA + H(+)"}
{"X":32113,"RHEA_ID":30140,"DIRECTION":"LR","MASTER_ID":30139,"metacyc":"RXN-9624","compounds":"H2O + octadecanoyl-CoA => CoA + H(+) + octadecanoate"}
{"X":32114,"RHEA_ID":30141,"compounds":"CoA + H(+) + octadecanoate => H2O + octadecanoyl-CoA"}
{"X":32115,"RHEA_ID":40116,"compounds":"H2O + hexanoyl-CoA => CoA + H(+) + hexanoate"}
{"X":32116,"RHEA_ID":30144,"compounds":"H2O + octanoyl-CoA => CoA + H(+) + octanoate"}
{"X":32117,"RHEA_ID":30145,"compounds":"CoA + H(+) + octanoate => H2O + octanoyl-CoA"}
{"X":32118,"RHEA_ID":30146,"compounds":"H2O + octanoyl-CoA <=> CoA + H(+) + octanoate"}
{"X":32119,"RHEA_ID":30147,"DIRECTION":"UN","MASTER_ID":30147,"ec":"1.5.1.37","compounds":"FADH2 + NAD(+) = FAD + 2 H(+) + NADH"}
{"X":32120,"RHEA_ID":30147,"DIRECTION":"UN","MASTER_ID":30147,"ec":"1.5.1.45","compounds":"FADH2 + NAD(+) = FAD + 2 H(+) + NADH"}
{"X":32121,"RHEA_ID":30148,"DIRECTION":"LR","MASTER_ID":30147,"ecocyc":"RXN-8506","metacyc":"RXN-8506","compounds":"FADH2 + NAD(+) => FAD + 2 H(+) + NADH"}
{"X":32122,"RHEA_ID":30149,"compounds":"FAD + 2 H(+) + NADH => FADH2 + NAD(+)"}
{"X":32123,"RHEA_ID":40124,"compounds":"an omega-hydroxy fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => an omega-oxo fatty acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":32124,"RHEA_ID":30151,"DIRECTION":"UN","MASTER_ID":30151,"ec":"1.5.1.45","compounds":"FADH2 + NADP(+) = FAD + 2 H(+) + NADPH"}
{"X":32125,"RHEA_ID":30152,"compounds":"FADH2 + NADP(+) => FAD + 2 H(+) + NADPH"}
{"X":32126,"RHEA_ID":30153,"compounds":"FAD + 2 H(+) + NADPH => FADH2 + NADP(+)"}
{"X":32127,"RHEA_ID":50101,"compounds":"dodecanoyl-CoA + taurine => CoA + H(+) + N-dodecanoyl-taurine"}
{"X":32128,"RHEA_ID":30155,"compounds":"FADH2 + 2 Fe(3+) = FAD + 2 Fe(2+) + 3 H(+)"}
{"X":32129,"RHEA_ID":30156,"compounds":"FADH2 + 2 Fe(3+) => FAD + 2 Fe(2+) + 3 H(+)"}
{"X":32130,"RHEA_ID":30157,"compounds":"FAD + 2 Fe(2+) + 3 H(+) => FADH2 + 2 Fe(3+)"}
{"X":32131,"RHEA_ID":40132,"DIRECTION":"LR","MASTER_ID":40131,"metacyc":"RXN-10662","compounds":"(9Z)-hexadecenoyl-CoA + H2O => (9Z)-hexadecenoate + CoA + H(+)"}
{"X":32132,"RHEA_ID":30159,"compounds":"germacra-1(10),4,11(13)-trien-12-ol + NADP(+) = germacra-1(10),4,11(13)-trien-12-al + H(+) + NADPH"}
{"X":32133,"RHEA_ID":30160,"DIRECTION":"LR","MASTER_ID":30159,"metacyc":"RXN-8969","compounds":"germacra-1(10),4,11(13)-trien-12-ol + NADP(+) => germacra-1(10),4,11(13)-trien-12-al + H(+) + NADPH"}
{"X":32134,"RHEA_ID":30161,"compounds":"germacra-1(10),4,11(13)-trien-12-al + H(+) + NADPH => germacra-1(10),4,11(13)-trien-12-ol + NADP(+)"}
{"X":32135,"RHEA_ID":30163,"compounds":"germacra-1(10),4,11(13)-trien-12-al + H2O + NADP(+) = germacra-1(10),4,11(13)-trien-12-oate + 2 H(+) + NADPH"}
{"X":32136,"RHEA_ID":30164,"DIRECTION":"LR","MASTER_ID":30163,"metacyc":"RXN-8970","compounds":"germacra-1(10),4,11(13)-trien-12-al + H2O + NADP(+) => germacra-1(10),4,11(13)-trien-12-oate + 2 H(+) + NADPH"}
{"X":32137,"RHEA_ID":30165,"compounds":"germacra-1(10),4,11(13)-trien-12-oate + 2 H(+) + NADPH => germacra-1(10),4,11(13)-trien-12-al + H2O + NADP(+)"}
{"X":32138,"RHEA_ID":30167,"compounds":"D-erythrose 4-phosphate + dihydroxyacetone phosphate = sedoheptulose 1,7-bisphosphate"}
{"X":32139,"RHEA_ID":30168,"compounds":"D-erythrose 4-phosphate + dihydroxyacetone phosphate => sedoheptulose 1,7-bisphosphate"}
{"X":32140,"RHEA_ID":30169,"DIRECTION":"RL","MASTER_ID":30167,"ecocyc":"SEDOBISALDOL-RXN","compounds":"sedoheptulose 1,7-bisphosphate => D-erythrose 4-phosphate + dihydroxyacetone phosphate"}
{"X":32141,"RHEA_ID":40144,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + H2O => (9Z,12Z)-octadecadienoate + CoA + H(+)"}
{"X":32142,"RHEA_ID":40145,"compounds":"(9Z,12Z)-octadecadienoate + CoA + H(+) => (9Z,12Z)-octadecadienoyl-CoA + H2O"}
{"X":32143,"RHEA_ID":30172,"compounds":"hexadecanoyl-[ACP] + sn-glycerol 3-phosphate => 1-hexadecanoyl-sn-glycero-3-phosphate + holo-[ACP]"}
{"X":32144,"RHEA_ID":30173,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphate + holo-[ACP] => hexadecanoyl-[ACP] + sn-glycerol 3-phosphate"}
{"X":32145,"RHEA_ID":30174,"compounds":"hexadecanoyl-[ACP] + sn-glycerol 3-phosphate <=> 1-hexadecanoyl-sn-glycero-3-phosphate + holo-[ACP]"}
{"X":32146,"RHEA_ID":40149,"compounds":"CoA + eicosanoate + H(+) => eicosanoyl-CoA + H2O"}
{"X":32147,"RHEA_ID":30176,"compounds":"15-cis-phytoene + 2 plastoquinone-9 => 9,9',15-tri-cis-zeta-carotene + 2 plastoquinol-9"}
{"X":32148,"RHEA_ID":30177,"compounds":"9,9',15-tri-cis-zeta-carotene + 2 plastoquinol-9 => 15-cis-phytoene + 2 plastoquinone-9"}
{"X":32149,"RHEA_ID":30178,"compounds":"15-cis-phytoene + 2 plastoquinone-9 <=> 9,9',15-tri-cis-zeta-carotene + 2 plastoquinol-9"}
{"X":32150,"RHEA_ID":40153,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+) => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O"}
{"X":32151,"RHEA_ID":30180,"DIRECTION":"LR","MASTER_ID":30179,"metacyc":"RXN-12077","compounds":"oxalate + oxidized 2[4Fe-4S]-[ferredoxin] => 2 CO2 + reduced 2[4Fe-4S]-[ferredoxin]"}
{"X":32152,"RHEA_ID":30181,"compounds":"2 CO2 + reduced 2[4Fe-4S]-[ferredoxin] => oxalate + oxidized 2[4Fe-4S]-[ferredoxin]"}
{"X":32153,"RHEA_ID":30182,"compounds":"oxalate + oxidized 2[4Fe-4S]-[ferredoxin] <=> 2 CO2 + reduced 2[4Fe-4S]-[ferredoxin]"}
{"X":32154,"RHEA_ID":40157,"compounds":"22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":32155,"RHEA_ID":30184,"DIRECTION":"LR","MASTER_ID":30183,"ecocyc":"RXN0-5229","metacyc":"RXN0-5229","compounds":"L-galactonate + NAD(+) => H(+) + keto-D-tagaturonate + NADH"}
{"X":32156,"RHEA_ID":30185,"compounds":"H(+) + keto-D-tagaturonate + NADH => L-galactonate + NAD(+)"}
{"X":32157,"RHEA_ID":30186,"compounds":"L-galactonate + NAD(+) <=> H(+) + keto-D-tagaturonate + NADH"}
{"X":32158,"RHEA_ID":30187,"DIRECTION":"UN","MASTER_ID":30187,"ec":"1.3.5.2","compounds":"(S)-dihydroorotate + a quinone = a quinol + orotate"}
{"X":32159,"RHEA_ID":30188,"DIRECTION":"LR","MASTER_ID":30187,"ecocyc":"DIHYDROOROTATE-DEHYDROGENASE-RXN","metacyc":"DIHYDROOROTATE-DEHYDROGENASE-RXN","compounds":"(S)-dihydroorotate + a quinone => a quinol + orotate"}
{"X":32160,"RHEA_ID":30189,"compounds":"a quinol + orotate => (S)-dihydroorotate + a quinone"}
{"X":32161,"RHEA_ID":40164,"compounds":"D-glyceraldehyde + H2O + NADP(+) => (R)-glycerate + 2 H(+) + NADPH"}
{"X":32162,"RHEA_ID":40165,"compounds":"(R)-glycerate + 2 H(+) + NADPH => D-glyceraldehyde + H2O + NADP(+)"}
{"X":32163,"RHEA_ID":30192,"compounds":"15-cis-phytoene + plastoquinone-9 => 15,9'-di-cis-phytofluene + plastoquinol-9"}
{"X":32164,"RHEA_ID":30193,"compounds":"15,9'-di-cis-phytofluene + plastoquinol-9 => 15-cis-phytoene + plastoquinone-9"}
{"X":32165,"RHEA_ID":30194,"compounds":"15-cis-phytoene + plastoquinone-9 <=> 15,9'-di-cis-phytofluene + plastoquinol-9"}
{"X":32166,"RHEA_ID":40169,"compounds":"(2E)-hexadecenoyl-CoA + H2O2 => hexadecanoyl-CoA + O2"}
{"X":32167,"RHEA_ID":30196,"compounds":"15,9'-di-cis-phytofluene + plastoquinone-9 => 9,9',15-tri-cis-zeta-carotene + plastoquinol-9"}
{"X":32168,"RHEA_ID":30197,"compounds":"9,9',15-tri-cis-zeta-carotene + plastoquinol-9 => 15,9'-di-cis-phytofluene + plastoquinone-9"}
{"X":32169,"RHEA_ID":30198,"compounds":"15,9'-di-cis-phytofluene + plastoquinone-9 <=> 9,9',15-tri-cis-zeta-carotene + plastoquinol-9"}
{"X":32170,"RHEA_ID":40173,"compounds":"(2E)-dodecenoyl-CoA + H2O2 => dodecanoyl-CoA + O2"}
{"X":32171,"RHEA_ID":30200,"compounds":"2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate => 2 ATP + benzoyl-CoA + 2 H2O + reduced 2[4Fe-4S]-[ferredoxin]"}
{"X":32172,"RHEA_ID":30201,"compounds":"2 ATP + benzoyl-CoA + 2 H2O + reduced 2[4Fe-4S]-[ferredoxin] => 2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate"}
{"X":32173,"RHEA_ID":40176,"compounds":"O2 + octanoyl-CoA => (2E)-octenoyl-CoA + H2O2"}
{"X":32174,"RHEA_ID":40177,"compounds":"(2E)-octenoyl-CoA + H2O2 => O2 + octanoyl-CoA"}
{"X":32175,"RHEA_ID":30204,"compounds":"H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate => 2 GDP + 2 H(+)"}
{"X":32176,"RHEA_ID":30205,"compounds":"2 GDP + 2 H(+) => H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate"}
{"X":32177,"RHEA_ID":30206,"compounds":"H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate <=> 2 GDP + 2 H(+)"}
{"X":32178,"RHEA_ID":40181,"compounds":"(2E)-decenoyl-CoA + H2O2 => decanoyl-CoA + O2"}
{"X":32179,"RHEA_ID":30208,"DIRECTION":"LR","MASTER_ID":30207,"metacyc":"RXN-2841","compounds":"H2O + methylamine + 2 oxidized [amicyanin] => formaldehyde + 2 H(+) + NH4(+) + 2 reduced [amicyanin]"}
{"X":32180,"RHEA_ID":30209,"compounds":"formaldehyde + 2 H(+) + NH4(+) + 2 reduced [amicyanin] => H2O + methylamine + 2 oxidized [amicyanin]"}
{"X":32181,"RHEA_ID":30211,"DIRECTION":"UN","MASTER_ID":30211,"ec":"1.7.2.5","compounds":"2 [Fe(III)cytochrome c] + H2O + nitrous oxide = 2 [Fe(II)cytochrome c] + 2 H(+) + 2 nitric oxide"}
{"X":32182,"RHEA_ID":30212,"compounds":"2 [Fe(III)cytochrome c] + H2O + nitrous oxide => 2 [Fe(II)cytochrome c] + 2 H(+) + 2 nitric oxide"}
{"X":32183,"RHEA_ID":30213,"DIRECTION":"RL","MASTER_ID":30211,"metacyc":"NITRIC-OXIDE-REDUCTASE-RXN","compounds":"2 [Fe(II)cytochrome c] + 2 H(+) + 2 nitric oxide => 2 [Fe(III)cytochrome c] + H2O + nitrous oxide"}
{"X":32184,"RHEA_ID":30215,"DIRECTION":"UN","MASTER_ID":30215,"ec":"1.7.5.2","compounds":"a menaquinol + 2 nitric oxide = a menaquinone + H2O + nitrous oxide"}
{"X":32185,"RHEA_ID":30216,"DIRECTION":"LR","MASTER_ID":30215,"metacyc":"RXN-12129","compounds":"a menaquinol + 2 nitric oxide => a menaquinone + H2O + nitrous oxide"}
{"X":32186,"RHEA_ID":30217,"compounds":"a menaquinone + H2O + nitrous oxide => a menaquinol + 2 nitric oxide"}
{"X":32187,"RHEA_ID":30219,"DIRECTION":"UN","MASTER_ID":30219,"ec":"1.8.1.17","compounds":"dimethyl sulfoxide + H2O + NAD(+) = dimethyl sulfone + H(+) + NADH"}
{"X":32188,"RHEA_ID":40194,"compounds":"(3R)-hydroxyoctanoyl-CoA + NAD(+) <=> 3-oxooctanoyl-CoA + H(+) + NADH"}
{"X":32189,"RHEA_ID":40195,"compounds":"(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":32190,"RHEA_ID":40196,"compounds":"(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":32191,"RHEA_ID":40197,"compounds":"1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate"}
{"X":32192,"RHEA_ID":40198,"compounds":"(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":32193,"RHEA_ID":40199,"DIRECTION":"UN","MASTER_ID":40199,"ec":"1.14.14.80","compounds":"hexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 16-hydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":32194,"RHEA_ID":30227,"DIRECTION":"UN","MASTER_ID":30227,"ec":"1.8.2.4","compounds":"2 [Fe(III)-cytochrome c2] + dimethyl sulfide + H2O = 2 [Fe(II)-cytochrome c2] + dimethyl sulfoxide + 2 H(+)"}
{"X":32195,"RHEA_ID":30228,"DIRECTION":"LR","MASTER_ID":30227,"metacyc":"RXN-9763","compounds":"2 [Fe(III)-cytochrome c2] + dimethyl sulfide + H2O => 2 [Fe(II)-cytochrome c2] + dimethyl sulfoxide + 2 H(+)"}
{"X":32196,"RHEA_ID":40203,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 14-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":32197,"RHEA_ID":30231,"DIRECTION":"UN","MASTER_ID":30231,"ec":"1.8.3.6","compounds":"H2O + O2 + S-(2E,6E)-farnesyl-L-cysteine = (2E,6E)-farnesal + H2O2 + L-cysteine"}
{"X":32198,"RHEA_ID":30232,"DIRECTION":"LR","MASTER_ID":30231,"metacyc":"RXN-11623","compounds":"H2O + O2 + S-(2E,6E)-farnesyl-L-cysteine => (2E,6E)-farnesal + H2O2 + L-cysteine"}
{"X":32199,"RHEA_ID":40207,"compounds":"(2E)-tetradecenedioyl-CoA + H2O = (3S)-hydroxytetradecanedioyl-CoA"}
{"X":32200,"RHEA_ID":40208,"compounds":"(2E)-tetradecenedioyl-CoA + H2O => (3S)-hydroxytetradecanedioyl-CoA"}
{"X":32201,"RHEA_ID":30235,"DIRECTION":"UN","MASTER_ID":30235,"ec":"1.2.1.88","compounds":"H2O + L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + L-glutamate + NADH"}
{"X":32202,"RHEA_ID":30236,"DIRECTION":"LR","MASTER_ID":30235,"ecocyc":"RXN-14116","metacyc":"RXN-14116","reactome":"R-HSA-70679.4","compounds":"H2O + L-glutamate 5-semialdehyde + NAD(+) => 2 H(+) + L-glutamate + NADH"}
{"X":32203,"RHEA_ID":40211,"compounds":"(3S)-hydroxytetradecanedioyl-CoA + NAD(+) = 3-oxotetradecanedioyl-CoA + H(+) + NADH"}
{"X":32204,"RHEA_ID":40212,"compounds":"(3S)-hydroxytetradecanedioyl-CoA + NAD(+) => 3-oxotetradecanedioyl-CoA + H(+) + NADH"}
{"X":32205,"RHEA_ID":30239,"DIRECTION":"UN","MASTER_ID":30239,"ec":"1.8.5.4","compounds":"n a quinone + n H(+) + n hydrogen sulfide = n a quinol + n sulfur"}
{"X":32206,"RHEA_ID":30240,"DIRECTION":"LR","MASTER_ID":30239,"metacyc":"R17-RXN","compounds":"n a quinone + n H(+) + n hydrogen sulfide => n a quinol + n sulfur"}
{"X":32207,"RHEA_ID":40215,"compounds":"FADH2 + O2 = FAD + H(+) + H2O2"}
{"X":32208,"RHEA_ID":30242,"compounds":"n a quinone + n H(+) + n hydrogen sulfide <=> n a quinol + n sulfur"}
{"X":32209,"RHEA_ID":30243,"DIRECTION":"UN","MASTER_ID":30243,"ec":"1.10.3.3","compounds":"4 L-ascorbate + O2 = 2 H2O + 4 monodehydro-L-ascorbate radical"}
{"X":32210,"RHEA_ID":30244,"DIRECTION":"LR","MASTER_ID":30243,"metacyc":"RXN-3541","compounds":"4 L-ascorbate + O2 => 2 H2O + 4 monodehydro-L-ascorbate radical"}
{"X":32211,"RHEA_ID":40219,"compounds":"H2O + malonyl-CoA = CoA + H(+) + malonate"}
{"X":32212,"RHEA_ID":40220,"compounds":"H2O + malonyl-CoA => CoA + H(+) + malonate"}
{"X":32213,"RHEA_ID":30247,"DIRECTION":"UN","MASTER_ID":30247,"ec":"1.10.3.9","compounds":"2 H2O + 4 hnu + 2 plastoquinone-9 = O2 + 2 plastoquinol-9"}
{"X":32214,"RHEA_ID":30248,"compounds":"2 H2O + 4 hnu + 2 plastoquinone-9 => O2 + 2 plastoquinol-9"}
{"X":32215,"RHEA_ID":40223,"compounds":"4,8-dimethylnonanoyl-CoA + H2O = 4,8-dimethylnonanoate + CoA + H(+)"}
{"X":32216,"RHEA_ID":30250,"compounds":"2 H2O + 4 hnu + 2 plastoquinone-9 <=> O2 + 2 plastoquinol-9"}
{"X":32217,"RHEA_ID":30251,"DIRECTION":"UN","MASTER_ID":30251,"ec":"7.1.1.3","compounds":"2 a ubiquinol + n H(+)(in) + O2 = 2 a ubiquinone + n H(+)(out) + 2 H2O"}
{"X":32218,"RHEA_ID":30252,"DIRECTION":"LR","MASTER_ID":30251,"ecocyc":"RXN0-5268","metacyc":"RXN0-5268","compounds":"2 a ubiquinol + n H(+)(in) + O2 => 2 a ubiquinone + n H(+)(out) + 2 H2O"}
{"X":32219,"RHEA_ID":40227,"DIRECTION":"UN","MASTER_ID":40227,"ec":"2.8.2.36","compounds":"3'-phosphoadenylyl sulfate + desulfo-A47934 = A47934 + adenosine 3',5'-bisphosphate + H(+)"}
{"X":32220,"RHEA_ID":30254,"compounds":"2 a ubiquinol + n H(+)(in) + O2 <=> 2 a ubiquinone + n H(+)(out) + 2 H2O"}
{"X":32221,"RHEA_ID":30255,"DIRECTION":"UN","MASTER_ID":30255,"ec":"1.10.3.11","compounds":"2 a ubiquinol + O2 = 2 a ubiquinone + 2 H2O"}
{"X":32222,"RHEA_ID":30256,"DIRECTION":"LR","MASTER_ID":30255,"metacyc":"RXN-6883","compounds":"2 a ubiquinol + O2 => 2 a ubiquinone + 2 H2O"}
{"X":32223,"RHEA_ID":40231,"compounds":"(25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + 2 H2O + 2 oxidized [adrenodoxin]"}
{"X":32224,"RHEA_ID":30259,"DIRECTION":"UN","MASTER_ID":30259,"ec":"7.1.1.5","compounds":"2 a menaquinol + O2 = 2 a menaquinone + 2 H2O"}
{"X":32225,"RHEA_ID":30260,"DIRECTION":"LR","MASTER_ID":30259,"metacyc":"RXN-12164","compounds":"2 a menaquinol + O2 => 2 a menaquinone + 2 H2O"}
{"X":32226,"RHEA_ID":40235,"DIRECTION":"UN","MASTER_ID":40235,"ec":"1.3.4.1","compounds":"coenzyme B + coenzyme M + fumarate = coenzyme M-coenzyme B heterodisulfide + succinate"}
{"X":32227,"RHEA_ID":30263,"compounds":"H2O2 + 2 L-ascorbate = 2 H2O + 2 monodehydro-L-ascorbate radical"}
{"X":32228,"RHEA_ID":30264,"DIRECTION":"LR","MASTER_ID":30263,"ecocyc":"RXN-3521","metacyc":"RXN-3521","compounds":"H2O2 + 2 L-ascorbate => 2 H2O + 2 monodehydro-L-ascorbate radical"}
{"X":32229,"RHEA_ID":30265,"compounds":"2 H2O + 2 monodehydro-L-ascorbate radical => H2O2 + 2 L-ascorbate"}
{"X":32230,"RHEA_ID":30267,"compounds":"2 monodehydro-L-ascorbate radical = L-ascorbate + L-dehydroascorbate"}
{"X":32231,"RHEA_ID":30268,"DIRECTION":"LR","MASTER_ID":30267,"ecocyc":"RXN-3523","metacyc":"RXN-3523","reactome":"R-HSA-9640302.1","compounds":"2 monodehydro-L-ascorbate radical => L-ascorbate + L-dehydroascorbate"}
{"X":32232,"RHEA_ID":40243,"compounds":"(3R)-hydroxyhexadecanoyl-CoA + NAD(+) = 3-oxohexadecanoyl-CoA + H(+) + NADH"}
{"X":32233,"RHEA_ID":30271,"DIRECTION":"UN","MASTER_ID":30271,"ec":"1.11.1.14","compounds":"2 (3,4-dimethoxyphenyl)methanol + H2O2 = 2 (3,4-dimethoxyphenyl)methanol radical + 2 H2O"}
{"X":32234,"RHEA_ID":30272,"DIRECTION":"LR","MASTER_ID":30271,"metacyc":"RXN-17136","compounds":"2 (3,4-dimethoxyphenyl)methanol + H2O2 => 2 (3,4-dimethoxyphenyl)methanol radical + 2 H2O"}
{"X":32235,"RHEA_ID":40247,"compounds":"H2O + rhodomycin D = 10-carboxy-13-deoxycarminomycin + H(+) + methanol"}
{"X":32236,"RHEA_ID":30275,"DIRECTION":"UN","MASTER_ID":30275,"ec":"1.11.1.21","compounds":"AH2 + H2O2 = A + 2 H2O"}
{"X":32237,"RHEA_ID":30276,"DIRECTION":"LR","MASTER_ID":30275,"ecocyc":"RXN-8667","metacyc":"RXN-8667","compounds":"AH2 + H2O2 => A + 2 H2O"}
{"X":32238,"RHEA_ID":30277,"compounds":"A + 2 H2O => AH2 + H2O2"}
{"X":32239,"RHEA_ID":30279,"DIRECTION":"UN","MASTER_ID":30279,"ec":"1.12.1.4","compounds":"2 H2 + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin] = 3 H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":32240,"RHEA_ID":30280,"compounds":"2 H2 + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin] => 3 H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":32241,"RHEA_ID":40255,"compounds":"(2E)-hexadecenedioyl-CoA + H2O = (3R)-hydroxyhexadecanedioyl-CoA"}
{"X":32242,"RHEA_ID":30283,"DIRECTION":"UN","MASTER_ID":30283,"ec":"3.1.1.88","compounds":"(-)-trans-permethrin + H2O = (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + (3-phenoxyphenyl)methanol + H(+)"}
{"X":32243,"RHEA_ID":30284,"DIRECTION":"LR","MASTER_ID":30283,"metacyc":"RXN-12167","compounds":"(-)-trans-permethrin + H2O => (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + (3-phenoxyphenyl)methanol + H(+)"}
{"X":32244,"RHEA_ID":30285,"compounds":"(1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + (3-phenoxyphenyl)methanol + H(+) => (-)-trans-permethrin + H2O"}
{"X":32245,"RHEA_ID":40260,"compounds":"(2E)-hexadecenedioyl-CoA + H2O => (3S)-hydroxyhexadecanedioyl-CoA"}
{"X":32246,"RHEA_ID":30287,"DIRECTION":"UN","MASTER_ID":30287,"ec":"1.3.5.5","compounds":"15-cis-phytoene + 2 a plastoquinone = 9,9',15-tri-cis-zeta-carotene + 2 a plastoquinol"}
{"X":32247,"RHEA_ID":30288,"DIRECTION":"LR","MASTER_ID":30287,"metacyc":"RXN-11355","compounds":"15-cis-phytoene + 2 a plastoquinone => 9,9',15-tri-cis-zeta-carotene + 2 a plastoquinol"}
{"X":32248,"RHEA_ID":40263,"compounds":"(3R)-hydroxyhexadecanedioyl-CoA + NAD(+) = 3-oxohexadecanedioyl-CoA + H(+) + NADH"}
{"X":32249,"RHEA_ID":40264,"compounds":"(3R)-hydroxyhexadecanedioyl-CoA + NAD(+) => 3-oxohexadecanedioyl-CoA + H(+) + NADH"}
{"X":32250,"RHEA_ID":30291,"DIRECTION":"UN","MASTER_ID":30291,"ec":"1.13.11.58","compounds":"(9Z,12Z)-octadecadienoate + O2 = (9S)-hydroperoxy-(10E,12Z)-octadecadienoate"}
{"X":32251,"RHEA_ID":30292,"DIRECTION":"LR","MASTER_ID":30291,"metacyc":"RXN-8495","compounds":"(9Z,12Z)-octadecadienoate + O2 => (9S)-hydroperoxy-(10E,12Z)-octadecadienoate"}
{"X":32252,"RHEA_ID":40267,"compounds":"(3S)-hydroxyhexadecanedioyl-CoA + NAD(+) = 3-oxohexadecanedioyl-CoA + H(+) + NADH"}
{"X":32253,"RHEA_ID":40268,"compounds":"(3S)-hydroxyhexadecanedioyl-CoA + NAD(+) => 3-oxohexadecanedioyl-CoA + H(+) + NADH"}
{"X":32254,"RHEA_ID":30295,"DIRECTION":"UN","MASTER_ID":30295,"ec":"2.7.1.40","compounds":"GTP + pyruvate = GDP + H(+) + phosphoenolpyruvate"}
{"X":32255,"RHEA_ID":30296,"compounds":"GTP + pyruvate => GDP + H(+) + phosphoenolpyruvate"}
{"X":32256,"RHEA_ID":40271,"compounds":"O2 + tetradecanedioyl-CoA = (2E)-tetradecenedioyl-CoA + H2O2"}
{"X":32257,"RHEA_ID":40272,"compounds":"O2 + tetradecanedioyl-CoA => (2E)-tetradecenedioyl-CoA + H2O2"}
{"X":32258,"RHEA_ID":30299,"DIRECTION":"UN","MASTER_ID":30299,"ec":"1.14.11.33","compounds":"2-oxoglutarate + a methylated nucleobase within DNA + O2 = a nucleobase within DNA + CO2 + formaldehyde + succinate"}
{"X":32259,"RHEA_ID":30300,"DIRECTION":"LR","MASTER_ID":30299,"ecocyc":"RXN-12353","metacyc":"RXN-12353","compounds":"2-oxoglutarate + a methylated nucleobase within DNA + O2 => a nucleobase within DNA + CO2 + formaldehyde + succinate"}
{"X":32260,"RHEA_ID":40275,"compounds":"hexadecanedioyl-CoA + O2 = (2E)-hexadecenedioyl-CoA + H2O2"}
{"X":32261,"RHEA_ID":30302,"compounds":"2-oxoglutarate + a methylated nucleobase within DNA + O2 <=> a nucleobase within DNA + CO2 + formaldehyde + succinate"}
{"X":32262,"RHEA_ID":30303,"DIRECTION":"UN","MASTER_ID":30303,"ec":"1.14.14.95","compounds":"(+)-(R)-germacrene A + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}
{"X":32263,"RHEA_ID":30304,"DIRECTION":"LR","MASTER_ID":30303,"metacyc":"RXN-19749","compounds":"(+)-(R)-germacrene A + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}
{"X":32264,"RHEA_ID":40279,"compounds":"(R)-carnitine + dodecanoyl-CoA = CoA + O-dodecanoyl-R-carnitine"}
{"X":32265,"RHEA_ID":40280,"compounds":"(R)-carnitine + dodecanoyl-CoA => CoA + O-dodecanoyl-R-carnitine"}
{"X":32266,"RHEA_ID":30307,"DIRECTION":"UN","MASTER_ID":30307,"ec":"1.14.13.128","compounds":"7-methylxanthine + H(+) + NADPH + O2 = formaldehyde + H2O + NADP(+) + xanthine"}
{"X":32267,"RHEA_ID":30308,"DIRECTION":"LR","MASTER_ID":30307,"metacyc":"RXN-11518","compounds":"7-methylxanthine + H(+) + NADPH + O2 => formaldehyde + H2O + NADP(+) + xanthine"}
{"X":32268,"RHEA_ID":40283,"compounds":"(R)-carnitine + hexadecanedioyl-CoA = CoA + O-hexadecanedioyl-L-carnitine"}
{"X":32269,"RHEA_ID":40284,"compounds":"(R)-carnitine + hexadecanedioyl-CoA => CoA + O-hexadecanedioyl-L-carnitine"}
{"X":32270,"RHEA_ID":30311,"DIRECTION":"UN","MASTER_ID":30311,"ec":"1.14.13.128","compounds":"7-methylxanthine + H(+) + NADH + O2 = formaldehyde + H2O + NAD(+) + xanthine"}
{"X":32271,"RHEA_ID":30312,"DIRECTION":"LR","MASTER_ID":30311,"metacyc":"RXN-11518","compounds":"7-methylxanthine + H(+) + NADH + O2 => formaldehyde + H2O + NAD(+) + xanthine"}
{"X":32272,"RHEA_ID":40287,"compounds":"ATP + CoA + decanedioate = AMP + decanedioyl-CoA + diphosphate"}
{"X":32273,"RHEA_ID":40288,"compounds":"ATP + CoA + decanedioate => AMP + decanedioyl-CoA + diphosphate"}
{"X":32274,"RHEA_ID":30315,"DIRECTION":"UN","MASTER_ID":30315,"ec":"1.14.13.178","compounds":"1,7-dimethylxanthine + H(+) + NADH + O2 = 7-methylxanthine + formaldehyde + H2O + NAD(+)"}
{"X":32275,"RHEA_ID":30316,"DIRECTION":"LR","MASTER_ID":30315,"metacyc":"RXN-11517","compounds":"1,7-dimethylxanthine + H(+) + NADH + O2 => 7-methylxanthine + formaldehyde + H2O + NAD(+)"}
{"X":32276,"RHEA_ID":30317,"compounds":"7-methylxanthine + formaldehyde + H2O + NAD(+) => 1,7-dimethylxanthine + H(+) + NADH + O2"}
{"X":32277,"RHEA_ID":40292,"compounds":"ATP + CoA + tetradecanedioate => AMP + diphosphate + tetradecanedioyl-CoA"}
{"X":32278,"RHEA_ID":30319,"DIRECTION":"UN","MASTER_ID":30319,"ec":"1.14.13.179","compounds":"H(+) + NADH + O2 + theobromine = 7-methylxanthine + formaldehyde + H2O + NAD(+)"}
{"X":32279,"RHEA_ID":30320,"DIRECTION":"LR","MASTER_ID":30319,"metacyc":"RXN-11516","compounds":"H(+) + NADH + O2 + theobromine => 7-methylxanthine + formaldehyde + H2O + NAD(+)"}
{"X":32280,"RHEA_ID":30321,"compounds":"7-methylxanthine + formaldehyde + H2O + NAD(+) => H(+) + NADH + O2 + theobromine"}
{"X":32281,"RHEA_ID":40296,"compounds":"ATP + CoA + hexadecanedioate => AMP + diphosphate + hexadecanedioyl-CoA"}
{"X":32282,"RHEA_ID":30323,"compounds":"all-trans-beta-carotene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":32283,"RHEA_ID":30324,"DIRECTION":"LR","MASTER_ID":30323,"metacyc":"RXN-8025","compounds":"all-trans-beta-carotene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":32284,"RHEA_ID":40299,"DIRECTION":"UN","MASTER_ID":40299,"ec":"1.14.15.35","compounds":"6-deoxyerythronolide B + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = erythronolide B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":32285,"RHEA_ID":40300,"DIRECTION":"LR","MASTER_ID":40299,"metacyc":"RXN-12918","compounds":"6-deoxyerythronolide B + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => erythronolide B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":32286,"RHEA_ID":30327,"compounds":"beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = all-trans-zeaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":32287,"RHEA_ID":30328,"DIRECTION":"LR","MASTER_ID":30327,"metacyc":"RXN-8026","compounds":"beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => all-trans-zeaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":32288,"RHEA_ID":40303,"compounds":"A + dodecanedioyl-CoA = (2E)-dodecenedioyl-CoA + AH2"}
{"X":32289,"RHEA_ID":40304,"compounds":"A + dodecanedioyl-CoA => (2E)-dodecenedioyl-CoA + AH2"}
{"X":32290,"RHEA_ID":30331,"DIRECTION":"UN","MASTER_ID":30331,"ec":"1.14.15.24","compounds":"all-trans-beta-carotene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = all-trans-zeaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":32291,"RHEA_ID":30332,"DIRECTION":"LR","MASTER_ID":30331,"metacyc":"RXN1F-152","compounds":"all-trans-beta-carotene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => all-trans-zeaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":32292,"RHEA_ID":40307,"compounds":"A + decanedioyl-CoA = (2E)-decenedioyl-CoA + AH2"}
{"X":32293,"RHEA_ID":40308,"compounds":"A + decanedioyl-CoA => (2E)-decenedioyl-CoA + AH2"}
{"X":32294,"RHEA_ID":30335,"compounds":"CTP + H(+) + H2O = NH4(+) + UTP"}
{"X":32295,"RHEA_ID":30336,"compounds":"CTP + H(+) + H2O => NH4(+) + UTP"}
{"X":32296,"RHEA_ID":40311,"compounds":"hexanoyl-CoA + O2 = (2E)-hexenoyl-CoA + H2O2"}
{"X":32297,"RHEA_ID":40312,"compounds":"hexanoyl-CoA + O2 => (2E)-hexenoyl-CoA + H2O2"}
{"X":32298,"RHEA_ID":30339,"DIRECTION":"UN","MASTER_ID":30339,"ec":"4.1.1.105","compounds":"H(+) + L-tryptophan = CO2 + tryptamine"}
{"X":32299,"RHEA_ID":30339,"DIRECTION":"UN","MASTER_ID":30339,"ec":"4.1.1.28","compounds":"H(+) + L-tryptophan = CO2 + tryptamine"}
{"X":32300,"RHEA_ID":40315,"compounds":"glutaryl-CoA + O2 = (2E)-glutaconyl-CoA + H2O2"}
{"X":32301,"RHEA_ID":30341,"compounds":"CO2 + tryptamine => H(+) + L-tryptophan"}
{"X":32302,"RHEA_ID":40317,"compounds":"(2E)-glutaconyl-CoA + H2O2 => glutaryl-CoA + O2"}
{"X":32303,"RHEA_ID":30343,"compounds":"FAD + H(+) + succinate = FADH2 + fumarate"}
{"X":32304,"RHEA_ID":40319,"compounds":"O2 + tetracosanoyl-CoA = (2E)-tetracosenoyl-CoA + H2O2"}
{"X":32305,"RHEA_ID":30345,"compounds":"FADH2 + fumarate => FAD + H(+) + succinate"}
{"X":32306,"RHEA_ID":40321,"compounds":"(2E)-tetracosenoyl-CoA + H2O2 => O2 + tetracosanoyl-CoA"}
{"X":32307,"RHEA_ID":30347,"DIRECTION":"UN","MASTER_ID":30347,"ec":"2.7.4.6","compounds":"ATP + IDP = ADP + ITP"}
{"X":32308,"RHEA_ID":30348,"compounds":"ATP + IDP => ADP + ITP"}
{"X":32309,"RHEA_ID":30349,"compounds":"ADP + ITP => ATP + IDP"}
{"X":32310,"RHEA_ID":40325,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP"}
{"X":32311,"RHEA_ID":30351,"DIRECTION":"UN","MASTER_ID":30351,"ec":"1.14.13.130","compounds":"H(+) + NADH + O2 + pyrrole-2-carboxylate = 5-hydroxypyrrole-2-carboxylate + H2O + NAD(+)"}
{"X":32312,"RHEA_ID":30352,"DIRECTION":"LR","MASTER_ID":30351,"metacyc":"RXN-12222","compounds":"H(+) + NADH + O2 + pyrrole-2-carboxylate => 5-hydroxypyrrole-2-carboxylate + H2O + NAD(+)"}
{"X":32313,"RHEA_ID":40328,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":32314,"RHEA_ID":40329,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP"}
{"X":32315,"RHEA_ID":30355,"DIRECTION":"UN","MASTER_ID":30355,"ec":"1.14.18.3","compounds":"a quinol + methane + O2 = a quinone + H2O + methanol"}
{"X":32316,"RHEA_ID":30356,"DIRECTION":"LR","MASTER_ID":30355,"metacyc":"RXN-12219","compounds":"a quinol + methane + O2 => a quinone + H2O + methanol"}
{"X":32317,"RHEA_ID":40332,"compounds":"1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP => 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":32318,"RHEA_ID":30359,"DIRECTION":"UN","MASTER_ID":30359,"ec":"1.14.13.122","compounds":"chlorophyllide a + 2 H(+) + 2 NADPH + 2 O2 = chlorophyllide b + 3 H2O + 2 NADP(+)"}
{"X":32319,"RHEA_ID":30360,"DIRECTION":"LR","MASTER_ID":30359,"metacyc":"RXN-13398","compounds":"chlorophyllide a + 2 H(+) + 2 NADPH + 2 O2 => chlorophyllide b + 3 H2O + 2 NADP(+)"}
{"X":32320,"RHEA_ID":40336,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":32321,"RHEA_ID":40337,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP"}
{"X":32322,"RHEA_ID":30363,"DIRECTION":"UN","MASTER_ID":30363,"ec":"3.1.1.87","compounds":"fumonisin B1 + 2 H2O = (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + 2 H(+) + 2 tricarballylate"}
{"X":32323,"RHEA_ID":30364,"DIRECTION":"LR","MASTER_ID":30363,"metacyc":"RXN-12265","compounds":"fumonisin B1 + 2 H2O => (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + 2 H(+) + 2 tricarballylate"}
{"X":32324,"RHEA_ID":30365,"compounds":"(2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + 2 H(+) + 2 tricarballylate => fumonisin B1 + 2 H2O"}
{"X":32325,"RHEA_ID":40341,"compounds":"1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + ATP"}
{"X":32326,"RHEA_ID":30367,"DIRECTION":"UN","MASTER_ID":30367,"ec":"3.1.3.73","compounds":"adenosylcob(III)alamin 5'-phosphate + H2O = adenosylcob(III)alamin + phosphate"}
{"X":32327,"RHEA_ID":30368,"DIRECTION":"LR","MASTER_ID":30367,"ecocyc":"RXN-8770","metacyc":"RXN-8770","compounds":"adenosylcob(III)alamin 5'-phosphate + H2O => adenosylcob(III)alamin + phosphate"}
{"X":32328,"RHEA_ID":40344,"compounds":"3-oxohexadecanedioyl-CoA + CoA => acetyl-CoA + tetradecanedioyl-CoA"}
{"X":32329,"RHEA_ID":40345,"compounds":"acetyl-CoA + tetradecanedioyl-CoA => 3-oxohexadecanedioyl-CoA + CoA"}
{"X":32330,"RHEA_ID":30371,"DIRECTION":"UN","MASTER_ID":30371,"ec":"4.1.99.16","compounds":"(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O = (-)-geosmin + acetone"}
{"X":32331,"RHEA_ID":30372,"compounds":"(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O => (-)-geosmin + acetone"}
{"X":32332,"RHEA_ID":40348,"compounds":"3-oxotetradecanedioyl-CoA + CoA => acetyl-CoA + dodecanedioyl-CoA"}
{"X":32333,"RHEA_ID":40349,"compounds":"acetyl-CoA + dodecanedioyl-CoA => 3-oxotetradecanedioyl-CoA + CoA"}
{"X":32334,"RHEA_ID":30375,"DIRECTION":"UN","MASTER_ID":30375,"ec":"4.2.3.79","compounds":"(2E,6E)-farnesyl diphosphate = (+)-thujopsene + diphosphate"}
{"X":32335,"RHEA_ID":30376,"DIRECTION":"LR","MASTER_ID":30375,"metacyc":"RXN-8418","compounds":"(2E,6E)-farnesyl diphosphate => (+)-thujopsene + diphosphate"}
{"X":32336,"RHEA_ID":40352,"compounds":"1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP => 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":32337,"RHEA_ID":40353,"compounds":"1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+) => 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP"}
{"X":32338,"RHEA_ID":30379,"DIRECTION":"UN","MASTER_ID":30379,"ec":"4.2.3.78","compounds":"(2E,6E)-farnesyl diphosphate = (+)-beta-chamigrene + diphosphate"}
{"X":32339,"RHEA_ID":30380,"DIRECTION":"LR","MASTER_ID":30379,"metacyc":"RXN-8424","compounds":"(2E,6E)-farnesyl diphosphate => (+)-beta-chamigrene + diphosphate"}
{"X":32340,"RHEA_ID":40356,"compounds":"1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + ATP => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":32341,"RHEA_ID":40357,"compounds":"1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + ATP"}
{"X":32342,"RHEA_ID":30383,"DIRECTION":"UN","MASTER_ID":30383,"ec":"4.2.3.86","compounds":"(2E,6E)-farnesyl diphosphate = (-)-7-epi-alpha-selinene + diphosphate"}
{"X":32343,"RHEA_ID":30384,"DIRECTION":"LR","MASTER_ID":30383,"metacyc":"RXN-8609","compounds":"(2E,6E)-farnesyl diphosphate => (-)-7-epi-alpha-selinene + diphosphate"}
{"X":32344,"RHEA_ID":30385,"compounds":"(-)-7-epi-alpha-selinene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":32345,"RHEA_ID":40361,"compounds":"1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + ATP"}
{"X":32346,"RHEA_ID":30387,"DIRECTION":"UN","MASTER_ID":30387,"ec":"2.7.7.78","compounds":"GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate + GDP + H(+)"}
{"X":32347,"RHEA_ID":30388,"compounds":"GDP-alpha-D-glucose + phosphate => alpha-D-glucose 1-phosphate + GDP + H(+)"}
{"X":32348,"RHEA_ID":40364,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+)"}
{"X":32349,"RHEA_ID":50337,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + triacontanoate => H(+) + H2O + omega-hydroxy-triacontanoate + oxidized [NADPH--hemoprotein reductase]"}
{"X":32350,"RHEA_ID":30391,"DIRECTION":"UN","MASTER_ID":30391,"ec":"2.6.1.117","compounds":"4-methylsulfanyl-2-oxobutanoate + L-glutamine = 2-oxoglutaramate + L-methionine"}
{"X":32351,"RHEA_ID":30392,"compounds":"4-methylsulfanyl-2-oxobutanoate + L-glutamine => 2-oxoglutaramate + L-methionine"}
{"X":32352,"RHEA_ID":40368,"compounds":"1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP => 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+)"}
{"X":32353,"RHEA_ID":40369,"compounds":"1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+) => 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP"}
{"X":32354,"RHEA_ID":30399,"DIRECTION":"UN","MASTER_ID":30399,"ec":"1.14.14.158","compounds":"alpha-carotene + O2 + reduced [NADPH--hemoprotein reductase] = alpha-cryptoxanthin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":32355,"RHEA_ID":30400,"DIRECTION":"LR","MASTER_ID":30399,"metacyc":"RXN-12226","compounds":"alpha-carotene + O2 + reduced [NADPH--hemoprotein reductase] => alpha-cryptoxanthin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":32356,"RHEA_ID":40372,"DIRECTION":"LR","MASTER_ID":40371,"metacyc":"RXN-14706","compounds":"alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-di-trans,octa-cis-undecaprenol + ATP => 3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-di-trans,octa-cis-undecaprenol + ADP + H(+)"}
{"X":32357,"RHEA_ID":40373,"compounds":"3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-di-trans,octa-cis-undecaprenol + ADP + H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-di-trans,octa-cis-undecaprenol + ATP"}
{"X":32358,"RHEA_ID":30403,"DIRECTION":"UN","MASTER_ID":30403,"ec":"7.2.1.3","compounds":"Fe(3+)(out) + L-ascorbate(in) = Fe(2+)(out) + H(+) + monodehydro-L-ascorbate radical(in)"}
{"X":32359,"RHEA_ID":30404,"compounds":"Fe(3+)(out) + L-ascorbate(in) => Fe(2+)(out) + H(+) + monodehydro-L-ascorbate radical(in)"}
{"X":32360,"RHEA_ID":40376,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + ATP => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)"}
{"X":32361,"RHEA_ID":40377,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + ATP"}
{"X":32362,"RHEA_ID":30407,"DIRECTION":"UN","MASTER_ID":30407,"ec":"1.97.1.12","compounds":"hnu + oxidized [2Fe-2S]-[ferredoxin] + reduced [plastocyanin] = oxidized [plastocyanin] + reduced [2Fe-2S]-[ferredoxin]"}
{"X":32363,"RHEA_ID":30408,"DIRECTION":"LR","MASTER_ID":30407,"metacyc":"RXN490-3650","compounds":"hnu + oxidized [2Fe-2S]-[ferredoxin] + reduced [plastocyanin] => oxidized [plastocyanin] + reduced [2Fe-2S]-[ferredoxin]"}
{"X":32364,"RHEA_ID":40380,"compounds":"1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP => 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)"}
{"X":32365,"RHEA_ID":40381,"compounds":"1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+) => 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP"}
{"X":32366,"RHEA_ID":30411,"DIRECTION":"UN","MASTER_ID":30411,"ec":"2.3.1.196","compounds":"benzoyl-CoA + benzyl alcohol = benzyl benzoate + CoA"}
{"X":32367,"RHEA_ID":30412,"DIRECTION":"LR","MASTER_ID":30411,"metacyc":"RXN-6724","compounds":"benzoyl-CoA + benzyl alcohol => benzyl benzoate + CoA"}
{"X":32368,"RHEA_ID":40384,"compounds":"1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)"}
{"X":32369,"RHEA_ID":50357,"DIRECTION":"LR","MASTER_ID":50356,"metacyc":"RXN-17982","compounds":"4-hydroxy-6-methylpretetramide + NADPH + O2 => 4-dedimethylamino-4-oxo-anhydrotetracycline + H2O + NADP(+)"}
{"X":32370,"RHEA_ID":30415,"DIRECTION":"UN","MASTER_ID":30415,"ec":"4.1.99.5","compounds":"H(+) + 2 NADPH + O2 + octadecanal = formate + H2O + heptadecane + 2 NADP(+)"}
{"X":32371,"RHEA_ID":30416,"compounds":"H(+) + 2 NADPH + O2 + octadecanal => formate + H2O + heptadecane + 2 NADP(+)"}
{"X":32372,"RHEA_ID":40388,"compounds":"1,2-di-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP => 1,2-di(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)"}
{"X":32373,"RHEA_ID":40389,"compounds":"1,2-di(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+) => 1,2-di-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP"}
{"X":32374,"RHEA_ID":30423,"DIRECTION":"UN","MASTER_ID":30423,"ec":"4.2.3.76","compounds":"(2E,6E)-farnesyl diphosphate = (+)-delta-selinene + diphosphate"}
{"X":32375,"RHEA_ID":30424,"DIRECTION":"LR","MASTER_ID":30423,"metacyc":"RXN-8566","compounds":"(2E,6E)-farnesyl diphosphate => (+)-delta-selinene + diphosphate"}
{"X":32376,"RHEA_ID":40392,"compounds":"1-O-alkyl-2-acyl-sn-glycerol + an acyl-CoA => 1-O-alkyl-2,3-diacyl-sn-glycerol + CoA"}
{"X":32377,"RHEA_ID":40393,"compounds":"1-O-alkyl-2,3-diacyl-sn-glycerol + CoA => 1-O-alkyl-2-acyl-sn-glycerol + an acyl-CoA"}
{"X":32378,"RHEA_ID":40394,"compounds":"1-O-alkyl-2-acyl-sn-glycerol + an acyl-CoA <=> 1-O-alkyl-2,3-diacyl-sn-glycerol + CoA"}
{"X":32379,"RHEA_ID":30428,"DIRECTION":"LR","MASTER_ID":30427,"metacyc":"RXN-8939","compounds":"(2E,6E)-farnesyl diphosphate => (+)-germacrene D + diphosphate"}
{"X":32380,"RHEA_ID":30429,"compounds":"(+)-germacrene D + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":32381,"RHEA_ID":40397,"compounds":"H2O2 + NAD(+) => 1,2-dihydro-beta-NAD + H(+) + O2"}
{"X":32382,"RHEA_ID":30431,"DIRECTION":"UN","MASTER_ID":30431,"ec":"5.4.99.35","compounds":"(S)-2,3-epoxysqualene = taraxerol"}
{"X":32383,"RHEA_ID":30432,"DIRECTION":"LR","MASTER_ID":30431,"metacyc":"RXN-9916","compounds":"(S)-2,3-epoxysqualene => taraxerol"}
{"X":32384,"RHEA_ID":40400,"DIRECTION":"LR","MASTER_ID":40399,"metacyc":"RXN-15116","compounds":"1,2-dihydro-beta-NADP + H(+) + O2 => H2O2 + NADP(+)"}
{"X":32385,"RHEA_ID":40401,"compounds":"H2O2 + NADP(+) => 1,2-dihydro-beta-NADP + H(+) + O2"}
{"X":32386,"RHEA_ID":40402,"compounds":"1,2-dihydro-beta-NADP + H(+) + O2 <=> H2O2 + NADP(+)"}
{"X":32387,"RHEA_ID":30436,"DIRECTION":"LR","MASTER_ID":30435,"metacyc":"RXN-11295","compounds":"beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + glycyl-tRNA(Gly) => beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + H(+) + tRNA(Gly)"}
{"X":32388,"RHEA_ID":40404,"compounds":"1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":32389,"RHEA_ID":30439,"DIRECTION":"UN","MASTER_ID":30439,"ec":"2.3.2.17","compounds":"beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + 2 glycyl-tRNA(Gly) = 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly)"}
{"X":32390,"RHEA_ID":40407,"compounds":"1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":32391,"RHEA_ID":30441,"compounds":"2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly) => beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + 2 glycyl-tRNA(Gly)"}
{"X":32392,"RHEA_ID":30443,"DIRECTION":"UN","MASTER_ID":30443,"ec":"2.3.2.18","compounds":"2 glycyl-tRNA(Gly) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc = 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-penta-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly)"}
{"X":32393,"RHEA_ID":40411,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-CDP + myo-inositol = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)"}
{"X":32394,"RHEA_ID":40412,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-CDP + myo-inositol => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)"}
{"X":32395,"RHEA_ID":30447,"DIRECTION":"UN","MASTER_ID":30447,"ec":"1.14.13.179","compounds":"3-methylxanthine + H(+) + NADH + O2 = formaldehyde + H2O + NAD(+) + xanthine"}
{"X":32396,"RHEA_ID":40415,"compounds":"H2O + pristanoyl-CoA = 2,6,10,14-tetramethylpentadecanoate + CoA + H(+)"}
{"X":32397,"RHEA_ID":40416,"compounds":"H2O + pristanoyl-CoA => 2,6,10,14-tetramethylpentadecanoate + CoA + H(+)"}
{"X":32398,"RHEA_ID":40417,"compounds":"2,6,10,14-tetramethylpentadecanoate + CoA + H(+) => H2O + pristanoyl-CoA"}
{"X":32399,"RHEA_ID":30451,"DIRECTION":"UN","MASTER_ID":30451,"ec":"5.4.99.36","compounds":"(S)-2,3-epoxysqualene = isomultiflorenol"}
{"X":32400,"RHEA_ID":30452,"compounds":"(S)-2,3-epoxysqualene => isomultiflorenol"}
{"X":32401,"RHEA_ID":40420,"compounds":"H2O + phytanoyl-CoA => 3,7,11,15-tetramethylhexadecanoate + CoA + H(+)"}
{"X":32402,"RHEA_ID":40421,"compounds":"3,7,11,15-tetramethylhexadecanoate + CoA + H(+) => H2O + phytanoyl-CoA"}
{"X":32403,"RHEA_ID":30455,"DIRECTION":"UN","MASTER_ID":30455,"ec":"4.1.99.16","compounds":"(1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + H2O = (-)-geosmin"}
{"X":32404,"RHEA_ID":40423,"compounds":"(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + AH2 + O2 = (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + A + 2 H2O"}
{"X":32405,"RHEA_ID":30457,"compounds":"(-)-geosmin => (1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + H2O"}
{"X":32406,"RHEA_ID":40425,"compounds":"(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + A + 2 H2O => (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + AH2 + O2"}
{"X":32407,"RHEA_ID":30459,"DIRECTION":"UN","MASTER_ID":30459,"ec":"4.1.99.16","compounds":"(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol = (1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + acetone"}
{"X":32408,"RHEA_ID":40427,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":32409,"RHEA_ID":30461,"compounds":"(1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + acetone => (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol"}
{"X":32410,"RHEA_ID":40429,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O"}
{"X":32411,"RHEA_ID":30463,"DIRECTION":"UN","MASTER_ID":30463,"ec":"4.2.3.50","compounds":"(2Z,6Z)-farnesyl diphosphate = (+)-alpha-santalene + diphosphate"}
{"X":32412,"RHEA_ID":40431,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)"}
{"X":32413,"RHEA_ID":30465,"compounds":"(+)-alpha-santalene + diphosphate => (2Z,6Z)-farnesyl diphosphate"}
{"X":32414,"RHEA_ID":50405,"DIRECTION":"LR","MASTER_ID":50404,"metacyc":"RXN-17707","compounds":"(2-aminobenzoyl)acetate + H(+) + S-octanoyl-L-cysteinyl-[PqsC protein] => 1-(2-aminophenyl)decane-1,3-dione + CO2 + L-cysteinyl-[PqsC protein]"}
{"X":32415,"RHEA_ID":30467,"DIRECTION":"UN","MASTER_ID":30467,"ec":"4.2.3.53","compounds":"(2Z,6Z)-farnesyl diphosphate = (+)-endo-beta-bergamotene + diphosphate"}
{"X":32416,"RHEA_ID":40435,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine"}
{"X":32417,"RHEA_ID":30469,"compounds":"(+)-endo-beta-bergamotene + diphosphate => (2Z,6Z)-farnesyl diphosphate"}
{"X":32418,"RHEA_ID":40437,"compounds":"H(+) + hexadecanoate + sn-glycerol 3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":32419,"RHEA_ID":30471,"DIRECTION":"UN","MASTER_ID":30471,"ec":"4.2.3.54","compounds":"(2Z,6Z)-farnesyl diphosphate = (-)-endo-alpha-bergamotene + diphosphate"}
{"X":32420,"RHEA_ID":40439,"DIRECTION":"UN","MASTER_ID":40439,"ec":"5.3.1.31","compounds":"6-sulfo-D-quinovose = 6-deoxy-6-sulfo-D-fructose"}
{"X":32421,"RHEA_ID":30473,"compounds":"(-)-endo-alpha-bergamotene + diphosphate => (2Z,6Z)-farnesyl diphosphate"}
{"X":32422,"RHEA_ID":40441,"compounds":"6-deoxy-6-sulfo-D-fructose => 6-sulfo-D-quinovose"}
{"X":32423,"RHEA_ID":30475,"DIRECTION":"UN","MASTER_ID":30475,"ec":"3.2.1.167","compounds":"H2O + oroxylin A 7-O-beta-D-glucuronate = D-glucuronate + H(+) + oroxylin A"}
{"X":32424,"RHEA_ID":40443,"DIRECTION":"UN","MASTER_ID":40443,"ec":"2.7.1.184","compounds":"6-deoxy-6-sulfo-D-fructose + ATP = 6-deoxy-6-sulfo-D-fructose 1-phosphate + ADP + H(+)"}
{"X":32425,"RHEA_ID":30477,"compounds":"D-glucuronate + H(+) + oroxylin A => H2O + oroxylin A 7-O-beta-D-glucuronate"}
{"X":32426,"RHEA_ID":40445,"compounds":"6-deoxy-6-sulfo-D-fructose 1-phosphate + ADP + H(+) => 6-deoxy-6-sulfo-D-fructose + ATP"}
{"X":32427,"RHEA_ID":30479,"compounds":"L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase]"}
{"X":32428,"RHEA_ID":30481,"compounds":"2 H(+) + H2O + N-hydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase] => L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":32429,"RHEA_ID":40449,"compounds":"(2S)-pristanoyl-CoA => (2R)-pristanoyl-CoA"}
{"X":32430,"RHEA_ID":30483,"compounds":"N-hydroxy-L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase]"}
{"X":32431,"RHEA_ID":50423,"compounds":"L-leucyl-tRNA(Leu) + N-terminal L-aspartyl-[protein] <=> H(+) + N-terminal L-leucyl-L-aspartyl-[protein] + tRNA(Leu)"}
{"X":32432,"RHEA_ID":30485,"compounds":"H(+) + H2O + N,N-dihydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":32433,"RHEA_ID":40453,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphate + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O"}
{"X":32434,"RHEA_ID":30487,"compounds":"H(+) + N,N-dihydroxy-L-isoleucine = (1E,2S)-2-methylbutanal oxime + CO2 + H2O"}
{"X":32435,"RHEA_ID":50427,"compounds":"(8Z,11Z,14Z)-eicosatrienoate + 2 O2 <=> prostaglandin G1"}
{"X":32436,"RHEA_ID":30489,"compounds":"(1E,2S)-2-methylbutanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-isoleucine"}
{"X":32437,"RHEA_ID":40457,"compounds":"(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA"}
{"X":32438,"RHEA_ID":30491,"compounds":"L-valine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-valine + oxidized [NADPH--hemoprotein reductase]"}
{"X":32439,"RHEA_ID":40459,"compounds":"(2S)-pristanoyl-CoA + O2 = (2E)-pristenoyl-CoA + H2O2"}
{"X":32440,"RHEA_ID":30493,"compounds":"2 H(+) + H2O + N-hydroxy-L-valine + oxidized [NADPH--hemoprotein reductase] => L-valine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":32441,"RHEA_ID":40460,"DIRECTION":"LR","MASTER_ID":40459,"reactome":"R-HSA-389889.2","compounds":"(2S)-pristanoyl-CoA + O2 => (2E)-pristenoyl-CoA + H2O2"}
{"X":32442,"RHEA_ID":30495,"compounds":"N-hydroxy-L-valine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-valine + oxidized [NADPH--hemoprotein reductase]"}
{"X":32443,"RHEA_ID":50435,"compounds":"AH2 + prostaglandin G1 <=> A + H2O + prostaglandin H1"}
{"X":32444,"RHEA_ID":30497,"compounds":"H(+) + H2O + N,N-dihydroxy-L-valine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-valine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":32445,"RHEA_ID":40464,"compounds":"1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O => (9Z)-octadecenoate + 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+)"}
{"X":32446,"RHEA_ID":30499,"compounds":"H(+) + N,N-dihydroxy-L-valine = (E)-2-methylpropanal oxime + CO2 + H2O"}
{"X":32447,"RHEA_ID":40466,"compounds":"1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O <=> (9Z)-octadecenoate + 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+)"}
{"X":32448,"RHEA_ID":30501,"compounds":"(E)-2-methylpropanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-valine"}
{"X":32449,"RHEA_ID":30503,"compounds":"H2O + N-acetyl-L-glutamate 5-semialdehyde = acetate + L-glutamate 5-semialdehyde"}
{"X":32450,"RHEA_ID":40470,"compounds":"1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O <=> (9Z)-octadecenoate + 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+)"}
{"X":32451,"RHEA_ID":30505,"compounds":"acetate + L-glutamate 5-semialdehyde => H2O + N-acetyl-L-glutamate 5-semialdehyde"}
{"X":32452,"RHEA_ID":30506,"compounds":"H2O + N-acetyl-L-glutamate 5-semialdehyde <=> acetate + L-glutamate 5-semialdehyde"}
{"X":32453,"RHEA_ID":30507,"compounds":"2-demethylmenaquinone-8 + H(+) + NADH = 2-demethylmenaquinol-8 + NAD(+)"}
{"X":32454,"RHEA_ID":50447,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 O2 <=> prostaglandin G3"}
{"X":32455,"RHEA_ID":30509,"compounds":"2-demethylmenaquinol-8 + NAD(+) => 2-demethylmenaquinone-8 + H(+) + NADH"}
{"X":32456,"RHEA_ID":30510,"compounds":"2-demethylmenaquinone-8 + H(+) + NADH <=> 2-demethylmenaquinol-8 + NAD(+)"}
{"X":32457,"RHEA_ID":30511,"compounds":"2-demethylmenaquinone-8 + H(+) + NADPH = 2-demethylmenaquinol-8 + NADP(+)"}
{"X":32458,"RHEA_ID":40478,"compounds":"1,2,3-tributanoylglycerol + H2O <=> butanoate + dibutanoylglycerol + H(+)"}
{"X":32459,"RHEA_ID":30513,"compounds":"2-demethylmenaquinol-8 + NADP(+) => 2-demethylmenaquinone-8 + H(+) + NADPH"}
{"X":32460,"RHEA_ID":30514,"compounds":"2-demethylmenaquinone-8 + H(+) + NADPH <=> 2-demethylmenaquinol-8 + NADP(+)"}
{"X":32461,"RHEA_ID":30515,"DIRECTION":"UN","MASTER_ID":30515,"ec":"2.5.1.79","compounds":"S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = H(+) + S-methyl-5'-thioadenosine + thermospermine"}
{"X":32462,"RHEA_ID":40482,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)"}
{"X":32463,"RHEA_ID":30517,"compounds":"H(+) + S-methyl-5'-thioadenosine + thermospermine => S-adenosyl 3-(methylsulfanyl)propylamine + spermidine"}
{"X":32464,"RHEA_ID":50457,"compounds":"prostaglandin H3 => prostaglandin D3"}
{"X":32465,"RHEA_ID":30519,"DIRECTION":"UN","MASTER_ID":30519,"ec":"2.7.7.68","compounds":"GTP + H(+) + phosphoenolpyruvate = diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine"}
{"X":32466,"RHEA_ID":30520,"DIRECTION":"LR","MASTER_ID":30519,"metacyc":"RXN-8077","compounds":"GTP + H(+) + phosphoenolpyruvate => diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine"}
{"X":32467,"RHEA_ID":30521,"compounds":"diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine => GTP + H(+) + phosphoenolpyruvate"}
{"X":32468,"RHEA_ID":40488,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O => 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":32469,"RHEA_ID":30523,"DIRECTION":"UN","MASTER_ID":30523,"ec":"6.3.2.34","compounds":"GTP + L-glutamate + oxidized coenzyme F420-1 = GDP + H(+) + oxidized coenzyme F420-2 + phosphate"}
{"X":32470,"RHEA_ID":30524,"compounds":"GTP + L-glutamate + oxidized coenzyme F420-1 => GDP + H(+) + oxidized coenzyme F420-2 + phosphate"}
{"X":32471,"RHEA_ID":30525,"compounds":"GDP + H(+) + oxidized coenzyme F420-2 + phosphate => GTP + L-glutamate + oxidized coenzyme F420-1"}
{"X":32472,"RHEA_ID":40492,"compounds":"1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+)"}
{"X":32473,"RHEA_ID":30527,"DIRECTION":"UN","MASTER_ID":30527,"ec":"3.6.1.41","compounds":"H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate = ADP + ATP + 2 H(+)"}
{"X":32474,"RHEA_ID":30527,"DIRECTION":"UN","MASTER_ID":30527,"ec":"3.6.1.61","compounds":"H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate = ADP + ATP + 2 H(+)"}
{"X":32475,"RHEA_ID":30528,"compounds":"H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate => ADP + ATP + 2 H(+)"}
{"X":32476,"RHEA_ID":40496,"compounds":"N-[omega-(9Z,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine + O2 => N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine"}
{"X":32477,"RHEA_ID":40497,"compounds":"N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine => N-[omega-(9Z,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine + O2"}
{"X":32478,"RHEA_ID":30531,"compounds":"biotinate sulfoxide + H(+) + NADH = biotin + H2O + NAD(+)"}
{"X":32479,"RHEA_ID":40499,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-L-serine"}
{"X":32480,"RHEA_ID":40500,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O => (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-L-serine"}
{"X":32481,"RHEA_ID":30534,"compounds":"biotinate sulfoxide + H(+) + NADH <=> biotin + H2O + NAD(+)"}
{"X":32482,"RHEA_ID":30535,"compounds":"biotinate sulfoxide + H(+) + NADPH = biotin + H2O + NADP(+)"}
{"X":32483,"RHEA_ID":40503,"compounds":"N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine = N-[omega-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine"}
{"X":32484,"RHEA_ID":30537,"compounds":"biotin + H2O + NADP(+) => biotinate sulfoxide + H(+) + NADPH"}
{"X":32485,"RHEA_ID":30538,"compounds":"biotinate sulfoxide + H(+) + NADPH <=> biotin + H2O + NADP(+)"}
{"X":32486,"RHEA_ID":30539,"compounds":"(R)-carnitinyl-CoA = (S)-carnitinyl-CoA"}
{"X":32487,"RHEA_ID":40507,"compounds":"1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":32488,"RHEA_ID":40508,"compounds":"1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O => a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":32489,"RHEA_ID":30542,"DIRECTION":"BI","MASTER_ID":30539,"metacyc":"CARNCOARACE-RXN","compounds":"(R)-carnitinyl-CoA <=> (S)-carnitinyl-CoA"}
{"X":32490,"RHEA_ID":30543,"compounds":"(S)-carnitine + ATP + CoA = (S)-carnitinyl-CoA + ADP + phosphate"}
{"X":32491,"RHEA_ID":40511,"DIRECTION":"UN","MASTER_ID":40511,"ec":"1.1.1.373","compounds":"2,3-dihydroxypropane-1-sulfonate + NAD(+) = 3-sulfolactaldehyde + H(+) + NADH"}
{"X":32492,"RHEA_ID":30545,"compounds":"(S)-carnitinyl-CoA + ADP + phosphate => (S)-carnitine + ATP + CoA"}
{"X":32493,"RHEA_ID":30546,"DIRECTION":"BI","MASTER_ID":30543,"metacyc":"DCARNCOALIG-RXN","compounds":"(S)-carnitine + ATP + CoA <=> (S)-carnitinyl-CoA + ADP + phosphate"}
{"X":32494,"RHEA_ID":30547,"compounds":"(3S)-hydroxyhexanoyl-CoA = (2E)-hexenoyl-CoA + H2O"}
{"X":32495,"RHEA_ID":40515,"DIRECTION":"UN","MASTER_ID":40515,"ec":"4.1.2.57","compounds":"6-deoxy-6-sulfo-D-fructose 1-phosphate = 3-sulfolactaldehyde + dihydroxyacetone phosphate"}
{"X":32496,"RHEA_ID":40516,"DIRECTION":"LR","MASTER_ID":40515,"metacyc":"RXN-15298","compounds":"6-deoxy-6-sulfo-D-fructose 1-phosphate => 3-sulfolactaldehyde + dihydroxyacetone phosphate"}
{"X":32497,"RHEA_ID":40517,"compounds":"3-sulfolactaldehyde + dihydroxyacetone phosphate => 6-deoxy-6-sulfo-D-fructose 1-phosphate"}
{"X":32498,"RHEA_ID":30551,"compounds":"acetyl-CoA + beta-D-glucose = 6-O-acetyl-beta-D-glucose + CoA"}
{"X":32499,"RHEA_ID":30552,"compounds":"acetyl-CoA + beta-D-glucose => 6-O-acetyl-beta-D-glucose + CoA"}
{"X":32500,"RHEA_ID":50493,"DIRECTION":"LR","MASTER_ID":50492,"metacyc":"RXN-17851","compounds":"acetyl-CoA + N-terminal L-methionyl-L-glutaminyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutaminyl-[protein]"}
{"X":32501,"RHEA_ID":30554,"compounds":"acetyl-CoA + beta-D-glucose <=> 6-O-acetyl-beta-D-glucose + CoA"}
{"X":32502,"RHEA_ID":30555,"DIRECTION":"UN","MASTER_ID":30555,"ec":"6.3.2.31","compounds":"GTP + L-glutamate + oxidized F420-0 = GDP + H(+) + oxidized coenzyme F420-1 + phosphate"}
{"X":32503,"RHEA_ID":30556,"compounds":"GTP + L-glutamate + oxidized F420-0 => GDP + H(+) + oxidized coenzyme F420-1 + phosphate"}
{"X":32504,"RHEA_ID":40523,"DIRECTION":"UN","MASTER_ID":40523,"ec":"1.3.5.4","compounds":"a quinone + succinate = a quinol + fumarate"}
{"X":32505,"RHEA_ID":30558,"compounds":"GTP + L-glutamate + oxidized F420-0 <=> GDP + H(+) + oxidized coenzyme F420-1 + phosphate"}
{"X":32506,"RHEA_ID":30559,"compounds":"GTP + H2O = guanosine + H(+) + triphosphate"}
{"X":32507,"RHEA_ID":30560,"compounds":"GTP + H2O => guanosine + H(+) + triphosphate"}
{"X":32508,"RHEA_ID":40527,"DIRECTION":"UN","MASTER_ID":40527,"ec":"7.1.1.7","compounds":"2 a ubiquinol + 4 H(+)(in) + O2(in) = 2 a ubiquinone + 4 H(+)(out) + 2 H2O(in)"}
{"X":32509,"RHEA_ID":30562,"compounds":"GTP + H2O <=> guanosine + H(+) + triphosphate"}
{"X":32510,"RHEA_ID":30563,"DIRECTION":"UN","MASTER_ID":30563,"ec":"2.5.1.80","compounds":"dimethylallyl diphosphate + L-tryptophan = 7-(3-methylbut-2-enyl)-L-tryptophan + diphosphate"}
{"X":32511,"RHEA_ID":30564,"compounds":"dimethylallyl diphosphate + L-tryptophan => 7-(3-methylbut-2-enyl)-L-tryptophan + diphosphate"}
{"X":32512,"RHEA_ID":40531,"DIRECTION":"UN","MASTER_ID":40531,"ec":"1.14.15.33","compounds":"2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + neopikromycin + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":32513,"RHEA_ID":40532,"DIRECTION":"LR","MASTER_ID":40531,"metacyc":"RXN-15107","compounds":"2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + neopikromycin + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":32514,"RHEA_ID":30567,"DIRECTION":"UN","MASTER_ID":30567,"ec":"6.3.2.33","compounds":"5,6,7,8-tetrahydromethanopterin + ATP + L-glutamate = 5,6,7,8-tetrahydrosarcinapterin + ADP + H(+) + phosphate"}
{"X":32515,"RHEA_ID":30568,"DIRECTION":"LR","MASTER_ID":30567,"metacyc":"RXN-11103","compounds":"5,6,7,8-tetrahydromethanopterin + ATP + L-glutamate => 5,6,7,8-tetrahydrosarcinapterin + ADP + H(+) + phosphate"}
{"X":32516,"RHEA_ID":50509,"DIRECTION":"LR","MASTER_ID":50508,"metacyc":"RXN-17859","compounds":"acetyl-CoA + N-terminal L-valyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-valyl-[protein]"}
{"X":32517,"RHEA_ID":40536,"compounds":"4 H(+) + narbomycin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + novapikromycin + 4 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":32518,"RHEA_ID":30571,"DIRECTION":"UN","MASTER_ID":30571,"ec":"6.3.2.14","compounds":"3 2,3-dihydroxybenzoate + 6 ATP + 3 L-serine = 6 AMP + 6 diphosphate + enterobactin + 4 H(+)"}
{"X":32519,"RHEA_ID":30572,"DIRECTION":"LR","MASTER_ID":30571,"ecocyc":"ENTMULTI-RXN","metacyc":"ENTMULTI-RXN","compounds":"3 2,3-dihydroxybenzoate + 6 ATP + 3 L-serine => 6 AMP + 6 diphosphate + enterobactin + 4 H(+)"}
{"X":32520,"RHEA_ID":50513,"DIRECTION":"LR","MASTER_ID":50512,"metacyc":"RXN-17861","compounds":"acetyl-CoA + N-terminal L-cysteinyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-cysteinyl-[protein]"}
{"X":32521,"RHEA_ID":40540,"DIRECTION":"LR","MASTER_ID":40539,"metacyc":"RXN-15100","compounds":"10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + methymycin + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":32522,"RHEA_ID":30575,"compounds":"3 menaquinone-8 + protoporphyrinogen IX = 3 menaquinol-8 + protoporphyrin IX"}
{"X":32523,"RHEA_ID":30576,"compounds":"3 menaquinone-8 + protoporphyrinogen IX => 3 menaquinol-8 + protoporphyrin IX"}
{"X":32524,"RHEA_ID":40543,"DIRECTION":"UN","MASTER_ID":40543,"ec":"1.14.15.33","compounds":"10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + neomethymycin + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":32525,"RHEA_ID":30578,"compounds":"3 menaquinone-8 + protoporphyrinogen IX <=> 3 menaquinol-8 + protoporphyrin IX"}
{"X":32526,"RHEA_ID":30579,"compounds":"H2O + O-phospho-L-threonine = L-threonine + phosphate"}
{"X":32527,"RHEA_ID":30580,"compounds":"H2O + O-phospho-L-threonine => L-threonine + phosphate"}
{"X":32528,"RHEA_ID":50520,"DIRECTION":"UN","MASTER_ID":50520,"ec":"2.3.1.256","compounds":"acetyl-CoA + N-terminal L-methionyl-L-leucyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein]"}
{"X":32529,"RHEA_ID":30582,"compounds":"H2O + O-phospho-L-threonine <=> L-threonine + phosphate"}
{"X":32530,"RHEA_ID":30583,"compounds":"2-demethylmenaquinol-8 + H(+) + trimethylamine N-oxide = 2-demethylmenaquinone-8 + H2O + trimethylamine"}
{"X":32531,"RHEA_ID":30584,"compounds":"2-demethylmenaquinol-8 + H(+) + trimethylamine N-oxide => 2-demethylmenaquinone-8 + H2O + trimethylamine"}
{"X":32532,"RHEA_ID":50524,"DIRECTION":"UN","MASTER_ID":50524,"ec":"2.3.1.256","compounds":"acetyl-CoA + N-terminal L-methionyl-L-isoleucyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-isoleucyl-[protein]"}
{"X":32533,"RHEA_ID":30586,"compounds":"2-demethylmenaquinol-8 + H(+) + trimethylamine N-oxide <=> 2-demethylmenaquinone-8 + H2O + trimethylamine"}
{"X":32534,"RHEA_ID":30587,"compounds":"2-demethylmenaquinol-8 + dimethyl sulfoxide = 2-demethylmenaquinone-8 + dimethyl sulfide + H2O"}
{"X":32535,"RHEA_ID":30588,"compounds":"2-demethylmenaquinol-8 + dimethyl sulfoxide => 2-demethylmenaquinone-8 + dimethyl sulfide + H2O"}
{"X":32536,"RHEA_ID":50528,"DIRECTION":"UN","MASTER_ID":50528,"ec":"2.3.1.256","compounds":"acetyl-CoA + N-terminal L-methionyl-L-phenylalanyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein]"}
{"X":32537,"RHEA_ID":30590,"compounds":"2-demethylmenaquinol-8 + dimethyl sulfoxide <=> 2-demethylmenaquinone-8 + dimethyl sulfide + H2O"}
{"X":32538,"RHEA_ID":30591,"compounds":"H2O + O2 + tyramine = (4-hydroxyphenyl)acetaldehyde + H2O2 + NH4(+)"}
{"X":32539,"RHEA_ID":30592,"DIRECTION":"LR","MASTER_ID":30591,"metacyc":"RXN-5821","reactome":"R-HSA-5696146.1","compounds":"H2O + O2 + tyramine => (4-hydroxyphenyl)acetaldehyde + H2O2 + NH4(+)"}
{"X":32540,"RHEA_ID":40559,"compounds":"dTDP-beta-L-evernosamine + NADPH + O2 = dTDP-N-hydroxy-beta-L-evernosamine + H2O + NADP(+)"}
{"X":32541,"RHEA_ID":30593,"compounds":"(4-hydroxyphenyl)acetaldehyde + H2O2 + NH4(+) => H2O + O2 + tyramine"}
{"X":32542,"RHEA_ID":40561,"compounds":"dTDP-N-hydroxy-beta-L-evernosamine + H2O + NADP(+) => dTDP-beta-L-evernosamine + NADPH + O2"}
{"X":32543,"RHEA_ID":30595,"DIRECTION":"UN","MASTER_ID":30595,"ec":"1.14.14.9","compounds":"4-hydroxyphenylacetate + FADH2 + O2 = 3,4-dihydroxyphenylacetate + FAD + H(+) + H2O"}
{"X":32544,"RHEA_ID":50534,"compounds":"CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-tyrosyl-[protein]"}
{"X":32545,"RHEA_ID":30597,"compounds":"3,4-dihydroxyphenylacetate + FAD + H(+) + H2O => 4-hydroxyphenylacetate + FADH2 + O2"}
{"X":32546,"RHEA_ID":30598,"compounds":"4-hydroxyphenylacetate + FADH2 + O2 <=> 3,4-dihydroxyphenylacetate + FAD + H(+) + H2O"}
{"X":32547,"RHEA_ID":30599,"DIRECTION":"UN","MASTER_ID":30599,"ec":"1.3.99.28","compounds":"15-cis-phytoene + 3 A = 3 AH2 + all-trans-neurosporene"}
{"X":32548,"RHEA_ID":40567,"compounds":"AH2 + dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + O2 = A + dTDP-beta-L-evernitrose + H2O"}
{"X":32549,"RHEA_ID":30601,"compounds":"3 AH2 + all-trans-neurosporene => 15-cis-phytoene + 3 A"}
{"X":32550,"RHEA_ID":40569,"compounds":"A + dTDP-beta-L-evernitrose + H2O => AH2 + dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + O2"}
{"X":32551,"RHEA_ID":30603,"compounds":"15-cis-phytoene + A = AH2 + all-trans-phytofluene"}
{"X":32552,"RHEA_ID":40571,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":32553,"RHEA_ID":30605,"compounds":"AH2 + all-trans-phytofluene => 15-cis-phytoene + A"}
{"X":32554,"RHEA_ID":40573,"compounds":"2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O"}
{"X":32555,"RHEA_ID":30607,"compounds":"A + all-trans-phytofluene = AH2 + all-trans-zeta-carotene"}
{"X":32556,"RHEA_ID":40575,"compounds":"glutaryl-CoA + H2O = CoA + glutarate + H(+)"}
{"X":32557,"RHEA_ID":30609,"compounds":"AH2 + all-trans-zeta-carotene => A + all-trans-phytofluene"}
{"X":32558,"RHEA_ID":40577,"compounds":"CoA + glutarate + H(+) => glutaryl-CoA + H2O"}
{"X":32559,"RHEA_ID":30611,"compounds":"A + all-trans-zeta-carotene = AH2 + all-trans-neurosporene"}
{"X":32560,"RHEA_ID":50550,"compounds":"H2O + prostaglandin A1 => prostaglandin E1"}
{"X":32561,"RHEA_ID":30613,"compounds":"AH2 + all-trans-neurosporene => A + all-trans-zeta-carotene"}
{"X":32562,"RHEA_ID":40581,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+) => 1-O-(1Z)-hexadecenyl-2 (5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":32563,"RHEA_ID":30615,"DIRECTION":"UN","MASTER_ID":30615,"ec":"1.3.99.29","compounds":"15-cis-phytoene + 2 A = 2 AH2 + all-trans-zeta-carotene"}
{"X":32564,"RHEA_ID":40583,"compounds":"H2O + hexanedioyl-CoA = CoA + H(+) + hexanedioate"}
{"X":32565,"RHEA_ID":30617,"compounds":"2 AH2 + all-trans-zeta-carotene => 15-cis-phytoene + 2 A"}
{"X":32566,"RHEA_ID":40585,"compounds":"CoA + H(+) + hexanedioate => H2O + hexanedioyl-CoA"}
{"X":32567,"RHEA_ID":30619,"DIRECTION":"UN","MASTER_ID":30619,"ec":"1.3.99.26","compounds":"2 A + all-trans-zeta-carotene = 2 AH2 + all-trans-lycopene"}
{"X":32568,"RHEA_ID":50558,"compounds":"H2O + prostaglandin J2 => prostaglandin D2"}
{"X":32569,"RHEA_ID":30621,"compounds":"2 AH2 + all-trans-lycopene => 2 A + all-trans-zeta-carotene"}
{"X":32570,"RHEA_ID":40589,"compounds":"CoA + H(+) + octanedioate => H2O + octanedioyl-CoA"}
{"X":32571,"RHEA_ID":30623,"compounds":"A + all-trans-neurosporene = AH2 + all-trans-lycopene"}
{"X":32572,"RHEA_ID":50562,"compounds":"CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tryptophyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-tryptophyl-[protein]"}
{"X":32573,"RHEA_ID":30625,"compounds":"AH2 + all-trans-lycopene => A + all-trans-neurosporene"}
{"X":32574,"RHEA_ID":40593,"compounds":"CoA + decanedioate + H(+) => decanedioyl-CoA + H2O"}
{"X":32575,"RHEA_ID":30627,"DIRECTION":"UN","MASTER_ID":30627,"ec":"1.1.1.382","compounds":"(2R)-2,3-dihydroxy-3-methylbutanoate + NAD(+) = (2S)-2-acetolactate + H(+) + NADH"}
{"X":32576,"RHEA_ID":50566,"compounds":"CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-alanyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-alanyl-[protein]"}
{"X":32577,"RHEA_ID":30628,"compounds":"(2R)-2,3-dihydroxy-3-methylbutanoate + NAD(+) => (2S)-2-acetolactate + H(+) + NADH"}
{"X":32578,"RHEA_ID":30629,"compounds":"(2S)-2-acetolactate + H(+) + NADH => (2R)-2,3-dihydroxy-3-methylbutanoate + NAD(+)"}
{"X":32579,"RHEA_ID":40598,"compounds":"dodecanedioyl-CoA + H2O <=> CoA + dodecanedioate + H(+)"}
{"X":32580,"RHEA_ID":50570,"compounds":"CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-seryl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-seryl-[protein]"}
{"X":32581,"RHEA_ID":30631,"DIRECTION":"UN","MASTER_ID":30631,"ec":"2.4.1.264","compounds":"alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-diphospho-di-trans,octa-cis-undecaprenol + UDP-alpha-D-glucuronate = beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-diphospho-di-trans,octa-cis-undecaprenol + H(+) + UDP"}
{"X":32582,"RHEA_ID":30632,"DIRECTION":"LR","MASTER_ID":30631,"metacyc":"RXN-11790","compounds":"alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-diphospho-di-trans,octa-cis-undecaprenol + UDP-alpha-D-glucuronate => beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-diphospho-di-trans,octa-cis-undecaprenol + H(+) + UDP"}
{"X":32583,"RHEA_ID":30633,"compounds":"beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-diphospho-di-trans,octa-cis-undecaprenol + H(+) + UDP => alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-diphospho-di-trans,octa-cis-undecaprenol + UDP-alpha-D-glucuronate"}
{"X":32584,"RHEA_ID":60735,"compounds":"H2O + NADP(+) + perillyl aldehyde <=> 2 H(+) + NADPH + perillate"}
{"X":32585,"RHEA_ID":30635,"DIRECTION":"UN","MASTER_ID":30635,"ec":"2.4.1.267","compounds":"alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate = alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+)"}
{"X":32586,"RHEA_ID":30636,"DIRECTION":"LR","MASTER_ID":30635,"metacyc":"RXN-5470","compounds":"alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate => alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+)"}
{"X":32587,"RHEA_ID":30637,"compounds":"alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate"}
{"X":32588,"RHEA_ID":40607,"compounds":"1-tetradecanoyl-sn-glycerol + H2O = glycerol + H(+) + tetradecanoate"}
{"X":32589,"RHEA_ID":30639,"DIRECTION":"UN","MASTER_ID":30639,"ec":"2.4.1.269","compounds":"(R)-glycerate + GDP-alpha-D-mannose = (2R)-2-O-(alpha-D-mannosyl)-glycerate + GDP + H(+)"}
{"X":32590,"RHEA_ID":30640,"DIRECTION":"LR","MASTER_ID":30639,"metacyc":"RXN-8849","compounds":"(R)-glycerate + GDP-alpha-D-mannose => (2R)-2-O-(alpha-D-mannosyl)-glycerate + GDP + H(+)"}
{"X":32591,"RHEA_ID":30641,"compounds":"(2R)-2-O-(alpha-D-mannosyl)-glycerate + GDP + H(+) => (R)-glycerate + GDP-alpha-D-mannose"}
{"X":32592,"RHEA_ID":60743,"compounds":"(S)-(-)-citronellal + H2O + NADP(+) <=> (S)-(-)-citronellate + 2 H(+) + NADPH"}
{"X":32593,"RHEA_ID":30643,"DIRECTION":"UN","MASTER_ID":30643,"ec":"2.4.2.44","compounds":"phosphate + S-methyl-5'-thioinosine = hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate"}
{"X":32594,"RHEA_ID":30644,"DIRECTION":"LR","MASTER_ID":30643,"metacyc":"RXN-12241","compounds":"phosphate + S-methyl-5'-thioinosine => hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate"}
{"X":32595,"RHEA_ID":30645,"compounds":"hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate => phosphate + S-methyl-5'-thioinosine"}
{"X":32596,"RHEA_ID":50586,"compounds":"15-oxo-prostaglandin E1 + H(+) + NADPH => 13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+)"}
{"X":32597,"RHEA_ID":40616,"compounds":"H2O + tridecanoylglycerol => 2,3-didecanoyl-sn-glycerol + decanoate + H(+)"}
{"X":32598,"RHEA_ID":30648,"DIRECTION":"LR","MASTER_ID":30647,"metacyc":"RXN-11877","compounds":"1D-myo-inositol 3-phosphate + CTP + H(+) => CDP-1L-myo-inositol + diphosphate"}
{"X":32599,"RHEA_ID":30649,"compounds":"CDP-1L-myo-inositol + diphosphate => 1D-myo-inositol 3-phosphate + CTP + H(+)"}
{"X":32600,"RHEA_ID":50590,"compounds":"15-oxo-prostaglandin F2alpha + H(+) + NADPH => 13,14-dihydro-15-oxo-PGF2alpha + NADP(+)"}
{"X":32601,"RHEA_ID":40620,"compounds":"H2O + tridodecanoylglycerol => 2,3-didodecanoyl-sn-glycerol + dodecanoate + H(+)"}
{"X":32602,"RHEA_ID":30652,"compounds":"2 H2O + O2 + urate => allantoin + CO2 + H2O2"}
{"X":32603,"RHEA_ID":30653,"compounds":"allantoin + CO2 + H2O2 => 2 H2O + O2 + urate"}
{"X":32604,"RHEA_ID":40623,"compounds":"H2O + tritetradecanoylglycerol = 2,3-ditetradecanoyl-sn-glycerol + H(+) + tetradecanoate"}
{"X":32605,"RHEA_ID":30655,"compounds":"ATP + dUMP = ADP + dUDP"}
{"X":32606,"RHEA_ID":30656,"DIRECTION":"LR","MASTER_ID":30655,"metacyc":"RXN-14122","reactome":"R-HSA-73635.4","compounds":"ATP + dUMP => ADP + dUDP"}
{"X":32607,"RHEA_ID":30657,"DIRECTION":"RL","MASTER_ID":30655,"reactome":"R-HSA-75126.4","compounds":"ADP + dUDP => ATP + dUMP"}
{"X":32608,"RHEA_ID":50598,"compounds":"CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H4] => acetyl-CoA + N-terminal L-seryl-[histone H4]"}
{"X":32609,"RHEA_ID":30659,"compounds":"4-(phosphooxy)-L-threonine + H2O = 4-hydroxy-L-threonine + phosphate"}
{"X":32610,"RHEA_ID":30660,"compounds":"4-(phosphooxy)-L-threonine + H2O => 4-hydroxy-L-threonine + phosphate"}
{"X":32611,"RHEA_ID":30661,"compounds":"4-hydroxy-L-threonine + phosphate => 4-(phosphooxy)-L-threonine + H2O"}
{"X":32612,"RHEA_ID":50602,"compounds":"CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H2A] => acetyl-CoA + N-terminal L-seryl-[histone H2A]"}
{"X":32613,"RHEA_ID":40632,"compounds":"H2O + trioctadecanoylglycerol => 2,3-dioctadecanoyl-sn-glycerol + H(+) + octadecanoate"}
{"X":32614,"RHEA_ID":30664,"DIRECTION":"LR","MASTER_ID":30663,"metacyc":"RXN-19281","compounds":"3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole => hapalindole H"}
{"X":32615,"RHEA_ID":30665,"compounds":"hapalindole H => 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole"}
{"X":32616,"RHEA_ID":50606,"compounds":"CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein] => acetyl-CoA + N-terminal L-methionyl-[transmembrane protein]"}
{"X":32617,"RHEA_ID":40636,"compounds":"1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O => 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+) + hexadecanoate"}
{"X":32618,"RHEA_ID":30668,"compounds":"germacra-1(10),4,11(13)-trien-12-ol + H2O + 2 NADP(+) => germacra-1(10),4,11(13)-trien-12-oate + 3 H(+) + 2 NADPH"}
{"X":32619,"RHEA_ID":30669,"compounds":"germacra-1(10),4,11(13)-trien-12-oate + 3 H(+) + 2 NADPH => germacra-1(10),4,11(13)-trien-12-ol + H2O + 2 NADP(+)"}
{"X":32620,"RHEA_ID":50610,"compounds":"12-oxo-leukotriene B4 + H(+) + NADPH => leukotriene B4 + NADP(+)"}
{"X":32621,"RHEA_ID":40640,"compounds":"1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H2O => (9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+)"}
{"X":32622,"RHEA_ID":30672,"compounds":"H2O + N,N'-diacetylchitobiose => 2 N-acetyl-D-glucosamine"}
{"X":32623,"RHEA_ID":30673,"compounds":"2 N-acetyl-D-glucosamine => H2O + N,N'-diacetylchitobiose"}
{"X":32624,"RHEA_ID":50614,"compounds":"(2E)-dec-2-enal + H(+) + NADPH => decanal + NADP(+)"}
{"X":32625,"RHEA_ID":40644,"compounds":"1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O => (9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":32626,"RHEA_ID":30676,"compounds":"tetrahymanol => H2O + squalene"}
{"X":32627,"RHEA_ID":30677,"DIRECTION":"RL","MASTER_ID":30675,"metacyc":"RXN-12337","compounds":"H2O + squalene => tetrahymanol"}
{"X":32628,"RHEA_ID":50618,"compounds":"(3E)-3-nonen-2-one + H(+) + NADPH => NADP(+) + nonan-2-one"}
{"X":32629,"RHEA_ID":40648,"compounds":"1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+)"}
{"X":32630,"RHEA_ID":30680,"compounds":"D-cellobiose + H2O => 2 beta-D-glucose"}
{"X":32631,"RHEA_ID":30681,"compounds":"2 beta-D-glucose => D-cellobiose + H2O"}
{"X":32632,"RHEA_ID":40651,"compounds":"1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":32633,"RHEA_ID":40652,"compounds":"1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":32634,"RHEA_ID":30684,"DIRECTION":"LR","MASTER_ID":30683,"metacyc":"RXN-9987","reactome":"R-HSA-4085021.1","compounds":"H2O + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N-acetyl-D-mannosamine + UDP"}
{"X":32635,"RHEA_ID":30685,"compounds":"H(+) + N-acetyl-D-mannosamine + UDP => H2O + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":32636,"RHEA_ID":40655,"DIRECTION":"UN","MASTER_ID":40655,"ec":"2.8.3.20","compounds":"(R)-malate + succinyl-CoA = (R)-malyl-CoA + succinate"}
{"X":32637,"RHEA_ID":50627,"DIRECTION":"BI","MASTER_ID":50624,"metacyc":"RXN-18197","compounds":"acetyl-CoA + an omega-(methylsulfanyl)-2-oxoalkanoate + H2O <=> a 2-(omega-methylsulfanyl)alkylmalate + CoA + H(+)"}
{"X":32638,"RHEA_ID":30688,"compounds":"(4R)-4-hydroxy-2-oxoglutarate => glyoxylate + pyruvate"}
{"X":32639,"RHEA_ID":30689,"compounds":"glyoxylate + pyruvate => (4R)-4-hydroxy-2-oxoglutarate"}
{"X":32640,"RHEA_ID":40660,"compounds":"1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol => 1-O-hexadecylglycerone 3-phosphate + H(+) + hexadecanoate"}
{"X":32641,"RHEA_ID":30692,"compounds":"H2O2 + methanol => formaldehyde + 2 H2O"}
{"X":32642,"RHEA_ID":30693,"compounds":"formaldehyde + 2 H2O => H2O2 + methanol"}
{"X":32643,"RHEA_ID":40664,"DIRECTION":"LR","MASTER_ID":40663,"ecocyc":"RXN-15125","metacyc":"RXN-15125","compounds":"L-serine => 2-aminoprop-2-enoate + H2O"}
{"X":32644,"RHEA_ID":40665,"compounds":"2-aminoprop-2-enoate + H2O => L-serine"}
{"X":32645,"RHEA_ID":30697,"compounds":"beta-alanine + 2 H(+) + NADH => 3-aminopropanal + H2O + NAD(+)"}
{"X":32646,"RHEA_ID":30699,"compounds":"2-oxoglutarate + beta-alanine = 3-oxopropanoate + L-glutamate"}
{"X":32647,"RHEA_ID":30700,"compounds":"2-oxoglutarate + beta-alanine => 3-oxopropanoate + L-glutamate"}
{"X":32648,"RHEA_ID":50642,"compounds":"3-(2-methylsulfanyl)ethylmalate => 2-(2-methylsulfanyl)ethylmalate"}
{"X":32649,"RHEA_ID":30703,"DIRECTION":"UN","MASTER_ID":30703,"ec":"4.1.1.91","compounds":"H(+) + salicylate = CO2 + phenol"}
{"X":32650,"RHEA_ID":30704,"DIRECTION":"LR","MASTER_ID":30703,"metacyc":"RXN-11736","compounds":"H(+) + salicylate => CO2 + phenol"}
{"X":32651,"RHEA_ID":30705,"compounds":"CO2 + phenol => H(+) + salicylate"}
{"X":32652,"RHEA_ID":40676,"DIRECTION":"LR","MASTER_ID":40675,"ecocyc":"RXN-15122","metacyc":"RXN-15122","compounds":"L-threonine => 2-aminobut-2-enoate + H2O"}
{"X":32653,"RHEA_ID":30708,"compounds":"putrescine + pyruvate => 4-aminobutanal + L-alanine"}
{"X":32654,"RHEA_ID":30709,"compounds":"4-aminobutanal + L-alanine => putrescine + pyruvate"}
{"X":32655,"RHEA_ID":40679,"compounds":"(9Z)-octadecen-1-ol + 1-hexadecanoylglycerone 3-phosphate = 1-O-(9Z)-octadecenylglycerone 3-phosphate + H(+) + hexadecanoate"}
{"X":32656,"RHEA_ID":40680,"compounds":"(9Z)-octadecen-1-ol + 1-hexadecanoylglycerone 3-phosphate => 1-O-(9Z)-octadecenylglycerone 3-phosphate + H(+) + hexadecanoate"}
{"X":32657,"RHEA_ID":30712,"compounds":"(S)-linalool => beta-myrcene + H2O"}
{"X":32658,"RHEA_ID":30713,"DIRECTION":"RL","MASTER_ID":30711,"metacyc":"RXN-12335","compounds":"beta-myrcene + H2O => (S)-linalool"}
{"X":32659,"RHEA_ID":50654,"compounds":"2-(2-methylsulfanyl)propylmaleate + H2O => 2-(3-methylsulfanyl)propylmalate"}
{"X":32660,"RHEA_ID":30715,"DIRECTION":"UN","MASTER_ID":30715,"ec":"5.4.4.4","compounds":"geraniol = (S)-linalool"}
{"X":32661,"RHEA_ID":30716,"compounds":"geraniol => (S)-linalool"}
{"X":32662,"RHEA_ID":30717,"compounds":"(S)-linalool => geraniol"}
{"X":32663,"RHEA_ID":50658,"compounds":"2-(2-methylsulfanyl)ethylmaleate + H2O => 3-(2-methylsulfanyl)ethylmalate"}
{"X":32664,"RHEA_ID":40688,"compounds":"1-hexadecanoylglycerone 3-phosphate + tetradecan-1-ol => 1-O-tetradecylglycerone 3-phosphate + H(+) + hexadecanoate"}
{"X":32665,"RHEA_ID":30720,"compounds":"acetyl-CoA + propanoyl-CoA => 2-methyl-3-oxobutanoyl-CoA + CoA"}
{"X":32666,"RHEA_ID":30721,"DIRECTION":"RL","MASTER_ID":30719,"reactome":"R-HSA-70844.3","compounds":"2-methyl-3-oxobutanoyl-CoA + CoA => acetyl-CoA + propanoyl-CoA"}
{"X":32667,"RHEA_ID":40691,"compounds":"1-hexadecanoylglycerone 3-phosphate + pentadecan-1-ol = 1-O-pentadecylglycerone 3-phosphate + H(+) + hexadecanoate"}
{"X":32668,"RHEA_ID":30723,"DIRECTION":"UN","MASTER_ID":30723,"ec":"1.3.7.8","compounds":"A + 2 ADP + H(+) + NH4(+) + 2 phosphate = AH2 + 2 ATP + H2O + hydroxylamine"}
{"X":32669,"RHEA_ID":30724,"compounds":"A + 2 ADP + H(+) + NH4(+) + 2 phosphate => AH2 + 2 ATP + H2O + hydroxylamine"}
{"X":32670,"RHEA_ID":30725,"compounds":"AH2 + 2 ATP + H2O + hydroxylamine => A + 2 ADP + H(+) + NH4(+) + 2 phosphate"}
{"X":32671,"RHEA_ID":30726,"compounds":"A + 2 ADP + H(+) + NH4(+) + 2 phosphate <=> AH2 + 2 ATP + H2O + hydroxylamine"}
{"X":32672,"RHEA_ID":40696,"compounds":"1-hexadecanoylglycerone 3-phosphate + heptadecan-1-ol => 1-O-heptadecylglycerone 3-phosphate + H(+) + hexadecanoate"}
{"X":32673,"RHEA_ID":30728,"compounds":"dATP + pyruvate => dADP + H(+) + phosphoenolpyruvate"}
{"X":32674,"RHEA_ID":30729,"DIRECTION":"RL","MASTER_ID":30727,"metacyc":"RXN-14192","compounds":"dADP + H(+) + phosphoenolpyruvate => dATP + pyruvate"}
{"X":32675,"RHEA_ID":40699,"compounds":"1-hexadecanoylglycerone 3-phosphate + octadecan-1-ol = 1-O-octadecylglycerone 3-phosphate + H(+) + hexadecanoate"}
{"X":32676,"RHEA_ID":40700,"compounds":"1-hexadecanoylglycerone 3-phosphate + octadecan-1-ol => 1-O-octadecylglycerone 3-phosphate + H(+) + hexadecanoate"}
{"X":32677,"RHEA_ID":30732,"DIRECTION":"LR","MASTER_ID":30731,"reactome":"R-HSA-77319.3","compounds":"butanoyl-CoA + FAD + H(+) => (2E)-butenoyl-CoA + FADH2"}
{"X":32678,"RHEA_ID":30733,"compounds":"(2E)-butenoyl-CoA + FADH2 => butanoyl-CoA + FAD + H(+)"}
{"X":32679,"RHEA_ID":50674,"compounds":"[(1->4)-N-acetyl-beta-D-glucosaminyl](n-2) + N,N'-diacetylchitobiose => [(1->4)-N-acetyl-beta-D-glucosaminyl](n) + H2O"}
{"X":32680,"RHEA_ID":40704,"compounds":"(9Z,12Z)-octadecadien-1-ol + 1-hexadecanoylglycerone 3-phosphate => 1-O-(9Z,12Z)-octadecadienylglycerone 3-phosphate + H(+) + hexadecanoate"}
{"X":32681,"RHEA_ID":30736,"DIRECTION":"LR","MASTER_ID":30735,"metacyc":"RXN-10952","reactome":"R-HSA-1855211.2","compounds":"1D-myo-inositol 4-phosphate + H2O => myo-inositol + phosphate"}
{"X":32682,"RHEA_ID":30737,"compounds":"myo-inositol + phosphate => 1D-myo-inositol 4-phosphate + H2O"}
{"X":32683,"RHEA_ID":50678,"compounds":"N-terminal L-aspartyl-[protein] + NH4(+) => H(+) + H2O + N-terminal L-asparaginyl-[protein]"}
{"X":32684,"RHEA_ID":40708,"compounds":"(9Z,12Z,15Z)-octadecatrien-1-ol + 1-hexadecanoylglycerone 3-phosphate => 1-O-(9Z,12Z,15Z)-octadecatrienylglycerone 3-phosphate + H(+) + hexadecanoate"}
{"X":32685,"RHEA_ID":30740,"DIRECTION":"LR","MASTER_ID":30739,"metacyc":"MYO-INOSITOL-1OR-4-MONOPHOSPHATASE-RXN","reactome":"R-HSA-1855210.2","compounds":"1D-myo-inositol 3-phosphate + H2O => myo-inositol + phosphate"}
{"X":32686,"RHEA_ID":30741,"compounds":"myo-inositol + phosphate => 1D-myo-inositol 3-phosphate + H2O"}
{"X":32687,"RHEA_ID":40711,"compounds":"1-octadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + H(+) + octadecanoate"}
{"X":32688,"RHEA_ID":30743,"compounds":"beta-nicotinamide D-riboside + H2O = D-ribose + H(+) + nicotinamide"}
{"X":32689,"RHEA_ID":30744,"compounds":"beta-nicotinamide D-riboside + H2O => D-ribose + H(+) + nicotinamide"}
{"X":32690,"RHEA_ID":30745,"compounds":"D-ribose + H(+) + nicotinamide => beta-nicotinamide D-riboside + H2O"}
{"X":32691,"RHEA_ID":40715,"compounds":"dihydroxyacetone phosphate + hexadecanoyl-CoA = 1-hexadecanoylglycerone 3-phosphate + CoA"}
{"X":32692,"RHEA_ID":60880,"compounds":"a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + H(+) + NAD(+)"}
{"X":32693,"RHEA_ID":30748,"DIRECTION":"LR","MASTER_ID":30747,"reactome":"R-HSA-77299.2","compounds":"FAD + H(+) + hexadecanoyl-CoA => (2E)-hexadecenoyl-CoA + FADH2"}
{"X":32694,"RHEA_ID":30749,"compounds":"(2E)-hexadecenoyl-CoA + FADH2 => FAD + H(+) + hexadecanoyl-CoA"}
{"X":32695,"RHEA_ID":40719,"DIRECTION":"UN","MASTER_ID":40719,"ec":"2.5.1.151","compounds":"an alkylcob(III)alamin + apo--[alkylcobalamin reductase] + glutathione = an S-substituted glutathione + cob(I)alamin--[alkylcobalamin reductase] + H(+)"}
{"X":32696,"RHEA_ID":40720,"DIRECTION":"LR","MASTER_ID":40719,"metacyc":"RXN-19370","compounds":"an alkylcob(III)alamin + apo--[alkylcobalamin reductase] + glutathione => an S-substituted glutathione + cob(I)alamin--[alkylcobalamin reductase] + H(+)"}
{"X":32697,"RHEA_ID":30752,"DIRECTION":"LR","MASTER_ID":30751,"reactome":"R-HSA-201035.2","compounds":"ATP + CoA + hexadecanoate => AMP + diphosphate + hexadecanoyl-CoA"}
{"X":32698,"RHEA_ID":30752,"DIRECTION":"LR","MASTER_ID":30751,"reactome":"R-HSA-434382.1","compounds":"ATP + CoA + hexadecanoate => AMP + diphosphate + hexadecanoyl-CoA"}
{"X":32699,"RHEA_ID":30753,"compounds":"AMP + diphosphate + hexadecanoyl-CoA => ATP + CoA + hexadecanoate"}
{"X":32700,"RHEA_ID":60888,"compounds":"a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine-phospho-ribonucleoside in mRNA + H2O = (N(7)-methyl 5'-triphospho-guanosine)-guanosine + a 5'-end phospho-ribonucleoside in mRNA + H(+)"}
{"X":32701,"RHEA_ID":30755,"compounds":"ATP + carbamate = ADP + carbamoyl phosphate"}
{"X":32702,"RHEA_ID":30756,"DIRECTION":"LR","MASTER_ID":30755,"ecocyc":"RXN-14196","metacyc":"RXN-14196","compounds":"ATP + carbamate => ADP + carbamoyl phosphate"}
{"X":32703,"RHEA_ID":30757,"compounds":"ADP + carbamoyl phosphate => ATP + carbamate"}
{"X":32704,"RHEA_ID":44033,"compounds":"9,10-epoxy-(12Z)-octadecenoate + H2O => 9,10-dihydroxy-(12Z)-octadecenoate"}
{"X":32705,"RHEA_ID":30759,"compounds":"5-methylcytosine + H(+) + H2O = NH4(+) + thymine"}
{"X":32706,"RHEA_ID":30760,"compounds":"5-methylcytosine + H(+) + H2O => NH4(+) + thymine"}
{"X":32707,"RHEA_ID":30761,"compounds":"NH4(+) + thymine => 5-methylcytosine + H(+) + H2O"}
{"X":32708,"RHEA_ID":60900,"compounds":"a cytidine in RNA + S-adenosyl-L-methionine = an N(3)-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":32709,"RHEA_ID":30763,"DIRECTION":"UN","MASTER_ID":30763,"ec":"1.4.1.23","compounds":"H2O + L-valine + NAD(+) = 3-methyl-2-oxobutanoate + H(+) + NADH + NH4(+)"}
{"X":32710,"RHEA_ID":30764,"compounds":"H2O + L-valine + NAD(+) => 3-methyl-2-oxobutanoate + H(+) + NADH + NH4(+)"}
{"X":32711,"RHEA_ID":30765,"compounds":"3-methyl-2-oxobutanoate + H(+) + NADH + NH4(+) => H2O + L-valine + NAD(+)"}
{"X":32712,"RHEA_ID":60904,"compounds":"(9Z,12Z,15Z)-octadecatrienoate + O2 = 13-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate"}
{"X":32713,"RHEA_ID":30767,"compounds":"D-glucurono-3,6-lactone + H2O = D-glucuronate + H(+)"}
{"X":32714,"RHEA_ID":30768,"compounds":"D-glucurono-3,6-lactone + H2O => D-glucuronate + H(+)"}
{"X":32715,"RHEA_ID":30769,"compounds":"D-glucuronate + H(+) => D-glucurono-3,6-lactone + H2O"}
{"X":32716,"RHEA_ID":60908,"compounds":"a cytidine in tRNA + S-adenosyl-L-methionine = an N(3)-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":32717,"RHEA_ID":30771,"compounds":"guanosine + H2O = D-ribose + guanine"}
{"X":32718,"RHEA_ID":30772,"DIRECTION":"LR","MASTER_ID":30771,"metacyc":"RXN0-366","compounds":"guanosine + H2O => D-ribose + guanine"}
{"X":32719,"RHEA_ID":30773,"compounds":"D-ribose + guanine => guanosine + H2O"}
{"X":32720,"RHEA_ID":40744,"DIRECTION":"LR","MASTER_ID":40743,"metacyc":"RXN-14617","compounds":"(20S)-ginsenoside Rd + 2 H2O => (20S)-ginsenoside C-K + 2 D-glucose"}
{"X":32721,"RHEA_ID":30775,"compounds":"H2O + O2 + pyridoxamine = H2O2 + NH4(+) + pyridoxal"}
{"X":32722,"RHEA_ID":30776,"compounds":"H2O + O2 + pyridoxamine => H2O2 + NH4(+) + pyridoxal"}
{"X":32723,"RHEA_ID":30777,"compounds":"H2O2 + NH4(+) + pyridoxal => H2O + O2 + pyridoxamine"}
{"X":32724,"RHEA_ID":60916,"compounds":"a cytidine in mRNA + S-adenosyl-L-methionine = an N(3)-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":32725,"RHEA_ID":30779,"compounds":"D-gluconate + FAD + H(+) = 2-dehydro-D-gluconate + FADH2"}
{"X":32726,"RHEA_ID":30780,"compounds":"D-gluconate + FAD + H(+) => 2-dehydro-D-gluconate + FADH2"}
{"X":32727,"RHEA_ID":30781,"compounds":"2-dehydro-D-gluconate + FADH2 => D-gluconate + FAD + H(+)"}
{"X":32728,"RHEA_ID":60920,"compounds":"2-oxoglutarate + an N(3)-methylcytidine in mRNA + O2 = a cytidine in mRNA + CO2 + formaldehyde + succinate"}
{"X":32729,"RHEA_ID":40753,"compounds":"1-(9Z)-octadecenoylglycerone 3-phosphate + hexadecanoate => (9Z)-octadecenoate + 1-hexadecanoylglycerone 3-phosphate"}
{"X":32730,"RHEA_ID":30784,"DIRECTION":"LR","MASTER_ID":30783,"metacyc":"GLYCERALDEHYDE-DEHYDRO-RXN","reactome":"R-HSA-6813749.2","compounds":"D-glyceraldehyde + H2O + NAD(+) => (R)-glycerate + 2 H(+) + NADH"}
{"X":32731,"RHEA_ID":30785,"compounds":"(R)-glycerate + 2 H(+) + NADH => D-glyceraldehyde + H2O + NAD(+)"}
{"X":32732,"RHEA_ID":60924,"compounds":"2-oxoglutarate + N(6)-methyl-L-lysyl-[protein] + O2 = CO2 + formaldehyde + L-lysyl-[protein] + succinate"}
{"X":32733,"RHEA_ID":40757,"compounds":"1-(9Z,12Z)-octadecadienoylglycerone 3-phosphate + hexadecanoate => (9Z,12Z)-octadecadienoate + 1-hexadecanoylglycerone 3-phosphate"}
{"X":32734,"RHEA_ID":30788,"compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 => (6R)-L-erythro-6,7-dihydrobiopterin + H2O + L-tyrosine"}
{"X":32735,"RHEA_ID":30789,"compounds":"(6R)-L-erythro-6,7-dihydrobiopterin + H2O + L-tyrosine => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2"}
{"X":32736,"RHEA_ID":60928,"compounds":"(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = 17-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":32737,"RHEA_ID":30791,"compounds":"dGTP + pyruvate = dGDP + H(+) + phosphoenolpyruvate"}
{"X":32738,"RHEA_ID":30792,"compounds":"dGTP + pyruvate => dGDP + H(+) + phosphoenolpyruvate"}
{"X":32739,"RHEA_ID":30793,"DIRECTION":"RL","MASTER_ID":30791,"metacyc":"RXN-14207","compounds":"dGDP + H(+) + phosphoenolpyruvate => dGTP + pyruvate"}
{"X":32740,"RHEA_ID":40764,"compounds":"(20S)-ginsenoside Re + H2O => (20S)-ginsenoside Rg1 + L-rhamnopyranose"}
{"X":32741,"RHEA_ID":40765,"compounds":"(20S)-ginsenoside Rg1 + L-rhamnopyranose => (20S)-ginsenoside Re + H2O"}
{"X":32742,"RHEA_ID":30796,"DIRECTION":"LR","MASTER_ID":30795,"metacyc":"2-KETO-ADIPATE-DEHYDROG-RXN","reactome":"R-HSA-71037.2","compounds":"2-oxoadipate + CoA + NAD(+) => CO2 + glutaryl-CoA + NADH"}
{"X":32743,"RHEA_ID":30797,"compounds":"CO2 + glutaryl-CoA + NADH => 2-oxoadipate + CoA + NAD(+)"}
{"X":32744,"RHEA_ID":50743,"compounds":"H2O + leukotriene C4 <=> glycine + leukotriene F4"}
{"X":32745,"RHEA_ID":40769,"compounds":"(20S)-ginsenoside Rg1 + D-xylose => (20S)-ginsenoside R1 + H2O"}
{"X":32746,"RHEA_ID":30800,"DIRECTION":"LR","MASTER_ID":30799,"reactome":"R-HSA-77312.2","compounds":"(3S)-hydroxybutanoyl-CoA + NAD(+) => acetoacetyl-CoA + H(+) + NADH"}
{"X":32747,"RHEA_ID":30801,"compounds":"acetoacetyl-CoA + H(+) + NADH => (3S)-hydroxybutanoyl-CoA + NAD(+)"}
{"X":32748,"RHEA_ID":60940,"compounds":"(9Z)-hexadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = (9Z)-16-hydroxyhexadec-9-enoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":32749,"RHEA_ID":30803,"compounds":"4-aminobutanal + H2O + NADP(+) = 4-aminobutanoate + 2 H(+) + NADPH"}
{"X":32750,"RHEA_ID":40774,"DIRECTION":"BI","MASTER_ID":40771,"metacyc":"RXN-14582","compounds":"(20S)-ginsenoside Rg1 + H2O <=> (20S)-ginsenoside F1 + D-glucose"}
{"X":32751,"RHEA_ID":30805,"compounds":"4-aminobutanoate + 2 H(+) + NADPH => 4-aminobutanal + H2O + NADP(+)"}
{"X":32752,"RHEA_ID":40776,"compounds":"2-amino-2-phenylacetonitrile + H(+) + 2 H2O => D-alpha-phenylglycine + NH4(+)"}
{"X":32753,"RHEA_ID":30807,"DIRECTION":"UN","MASTER_ID":30807,"ec":"1.5.1.1","compounds":"L-pipecolate + NAD(+) = Delta(1)-piperideine-2-carboxylate + H(+) + NADH"}
{"X":32754,"RHEA_ID":40778,"compounds":"2-amino-2-phenylacetonitrile + H(+) + 2 H2O <=> D-alpha-phenylglycine + NH4(+)"}
{"X":32755,"RHEA_ID":30809,"DIRECTION":"RL","MASTER_ID":30807,"metacyc":"RXN-8166","compounds":"Delta(1)-piperideine-2-carboxylate + H(+) + NADH => L-pipecolate + NAD(+)"}
{"X":32756,"RHEA_ID":60948,"compounds":"(S)-eriodictyol + S-adenosyl-L-methionine = (S)-homoeriodictyol + H(+) + S-adenosyl-L-homocysteine"}
{"X":32757,"RHEA_ID":30815,"compounds":"beta-nicotinamide D-ribonucleotide + H2O = beta-nicotinamide D-riboside + phosphate"}
{"X":32758,"RHEA_ID":40782,"compounds":"2-aminopentanenitrile + H(+) + 2 H2O <=> L-2-aminopentanoate + NH4(+)"}
{"X":32759,"RHEA_ID":30817,"compounds":"beta-nicotinamide D-riboside + phosphate => beta-nicotinamide D-ribonucleotide + H2O"}
{"X":32760,"RHEA_ID":30819,"compounds":"allantoin + H2O = allantoate + H(+)"}
{"X":32761,"RHEA_ID":40786,"compounds":"docosanoyl-CoA + H2O <=> CoA + docosanoate + H(+)"}
{"X":32762,"RHEA_ID":30821,"compounds":"allantoate + H(+) => allantoin + H2O"}
{"X":32763,"RHEA_ID":40788,"compounds":"H2O + tetracosanoyl-CoA => CoA + H(+) + tetracosanoate"}
{"X":32764,"RHEA_ID":30823,"DIRECTION":"UN","MASTER_ID":30823,"ec":"4.2.1.135","compounds":"UDP-N-acetyl-alpha-D-glucosamine = H2O + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose"}
{"X":32765,"RHEA_ID":40790,"compounds":"H2O + tetracosanoyl-CoA <=> CoA + H(+) + tetracosanoate"}
{"X":32766,"RHEA_ID":30825,"compounds":"H2O + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose => UDP-N-acetyl-alpha-D-glucosamine"}
{"X":32767,"RHEA_ID":60960,"compounds":"18-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose = (9Z)-18-hydroxyoctadec-9-enoate 18-O-beta-D-glucoside + H(+) + UDP"}
{"X":32768,"RHEA_ID":30827,"compounds":"UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose = UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose"}
{"X":32769,"RHEA_ID":40794,"compounds":"H2O + hexacosanoyl-CoA <=> CoA + H(+) + hexacosanoate"}
{"X":32770,"RHEA_ID":30829,"compounds":"UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose => UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose"}
{"X":32771,"RHEA_ID":40796,"compounds":"1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + L-serine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine"}
{"X":32772,"RHEA_ID":30831,"compounds":"UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose = UDP-2-acetamido-2,6-dideoxy-beta-L-lyxo-hex-4-ulose"}
{"X":32773,"RHEA_ID":30832,"compounds":"UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose => UDP-2-acetamido-2,6-dideoxy-beta-L-lyxo-hex-4-ulose"}
{"X":32774,"RHEA_ID":30833,"compounds":"UDP-2-acetamido-2,6-dideoxy-beta-L-lyxo-hex-4-ulose => UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose"}
{"X":32775,"RHEA_ID":40800,"compounds":"2-methylpropanoyl-CoA + H2O => 2-methylpropanoate + CoA + H(+)"}
{"X":32776,"RHEA_ID":30835,"DIRECTION":"UN","MASTER_ID":30835,"ec":"1.1.1.367","compounds":"H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose = NADP(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose"}
{"X":32777,"RHEA_ID":40802,"compounds":"2-methylpropanoyl-CoA + H2O <=> 2-methylpropanoate + CoA + H(+)"}
{"X":32778,"RHEA_ID":30837,"compounds":"NADP(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose => H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose"}
{"X":32779,"RHEA_ID":50779,"compounds":"hexanal + NADP(+) <=> (E)-2-hexenal + H(+) + NADPH"}
{"X":32780,"RHEA_ID":30839,"DIRECTION":"UN","MASTER_ID":30839,"ec":"5.1.3.28","compounds":"UDP-2-acetamido-2,6-dideoxy-beta-L-talose = UDP-N-acetyl-beta-L-fucosamine"}
{"X":32781,"RHEA_ID":50781,"compounds":"NADP(+) + octanal => (2E)-octenal + H(+) + NADPH"}
{"X":32782,"RHEA_ID":30841,"compounds":"UDP-N-acetyl-beta-L-fucosamine => UDP-2-acetamido-2,6-dideoxy-beta-L-talose"}
{"X":32783,"RHEA_ID":50783,"compounds":"NADP(+) + octanal <=> (2E)-octenal + H(+) + NADPH"}
{"X":32784,"RHEA_ID":30843,"DIRECTION":"UN","MASTER_ID":30843,"ec":"3.5.1.106","compounds":"H2O + N-formylmaleamate = formate + H(+) + maleamate"}
{"X":32785,"RHEA_ID":40810,"compounds":"a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + H(+) + sn-glycerol 3-phosphocholine"}
{"X":32786,"RHEA_ID":30845,"compounds":"formate + H(+) + maleamate => H2O + N-formylmaleamate"}
{"X":32787,"RHEA_ID":50787,"compounds":"dodecanal + NADP(+) <=> (2E)-dodecenal + H(+) + NADPH"}
{"X":32788,"RHEA_ID":30847,"compounds":"FAD + glutaryl-CoA + 2 H(+) = (2E)-butenoyl-CoA + CO2 + FADH2"}
{"X":32789,"RHEA_ID":40814,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":32790,"RHEA_ID":30849,"compounds":"(2E)-butenoyl-CoA + CO2 + FADH2 => FAD + glutaryl-CoA + 2 H(+)"}
{"X":32791,"RHEA_ID":50791,"compounds":"NADP(+) + pentan-2-one <=> 2-oxo-(3E)-pentene + H(+) + NADPH"}
{"X":32792,"RHEA_ID":30851,"compounds":"beta-D-fructose 1-phosphate = D-glyceraldehyde + dihydroxyacetone phosphate"}
{"X":32793,"RHEA_ID":40818,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)"}
{"X":32794,"RHEA_ID":30853,"compounds":"D-glyceraldehyde + dihydroxyacetone phosphate => beta-D-fructose 1-phosphate"}
{"X":32795,"RHEA_ID":40820,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":32796,"RHEA_ID":30855,"DIRECTION":"UN","MASTER_ID":30855,"ec":"4.2.1.125","compounds":"dammarenediol-II = (S)-2,3-epoxysqualene + H2O"}
{"X":32797,"RHEA_ID":40822,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":32798,"RHEA_ID":30857,"DIRECTION":"RL","MASTER_ID":30855,"metacyc":"RXN-8885","compounds":"(S)-2,3-epoxysqualene + H2O => dammarenediol-II"}
{"X":32799,"RHEA_ID":50799,"compounds":"glutathione + prostaglandin A2 <=> prostaglandin A2-S-(R)-glutathione"}
{"X":32800,"RHEA_ID":30859,"compounds":"dITP + H2O = dIDP + H(+) + phosphate"}
{"X":32801,"RHEA_ID":30860,"compounds":"dITP + H2O => dIDP + H(+) + phosphate"}
{"X":32802,"RHEA_ID":30861,"compounds":"dIDP + H(+) + phosphate => dITP + H2O"}
{"X":32803,"RHEA_ID":40828,"compounds":"2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine"}
{"X":32804,"RHEA_ID":30863,"compounds":"4-O-phospho-L-tyrosine + H2O = L-tyrosine + phosphate"}
{"X":32805,"RHEA_ID":40830,"compounds":"2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine"}
{"X":32806,"RHEA_ID":30865,"compounds":"L-tyrosine + phosphate => 4-O-phospho-L-tyrosine + H2O"}
{"X":32807,"RHEA_ID":30866,"compounds":"4-O-phospho-L-tyrosine + H2O <=> L-tyrosine + phosphate"}
{"X":32808,"RHEA_ID":30867,"compounds":"H2O + indole-3-acetaldehyde + NAD(+) = (indol-3-yl)acetate + 2 H(+) + NADH"}
{"X":32809,"RHEA_ID":30868,"DIRECTION":"LR","MASTER_ID":30867,"metacyc":"RXN-5581","compounds":"H2O + indole-3-acetaldehyde + NAD(+) => (indol-3-yl)acetate + 2 H(+) + NADH"}
{"X":32810,"RHEA_ID":30869,"compounds":"(indol-3-yl)acetate + 2 H(+) + NADH => H2O + indole-3-acetaldehyde + NAD(+)"}
{"X":32811,"RHEA_ID":40836,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2 H2O => 2 (9Z)-octadecenoate + 2 H(+) + sn-glycerol 3-phosphocholine"}
{"X":32812,"RHEA_ID":30871,"DIRECTION":"UN","MASTER_ID":30871,"ec":"2.7.1.229","compounds":"2-deoxy-D-ribose + ATP = 2-deoxy-D-ribose 5-phosphate + ADP + H(+)"}
{"X":32813,"RHEA_ID":50813,"DIRECTION":"LR","MASTER_ID":50812,"metacyc":"RXN-17521","compounds":"androst-4-ene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 1alpha-hydroxyandrost-4-ene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":32814,"RHEA_ID":30873,"compounds":"2-deoxy-D-ribose 5-phosphate + ADP + H(+) => 2-deoxy-D-ribose + ATP"}
{"X":32815,"RHEA_ID":40840,"compounds":"FAD + H(+) + nonanoyl-CoA => (2E)-nonenoyl-CoA + FADH2"}
{"X":32816,"RHEA_ID":30875,"compounds":"2-oxoglutarate + D-lysine = 6-amino-2-oxohexanoate + D-glutamate"}
{"X":32817,"RHEA_ID":40842,"compounds":"FAD + H(+) + nonanoyl-CoA <=> (2E)-nonenoyl-CoA + FADH2"}
{"X":32818,"RHEA_ID":30877,"compounds":"6-amino-2-oxohexanoate + D-glutamate => 2-oxoglutarate + D-lysine"}
{"X":32819,"RHEA_ID":40844,"compounds":"FAD + H(+) + octadecanoyl-CoA => (2E)-octadecenoyl-CoA + FADH2"}
{"X":32820,"RHEA_ID":30879,"compounds":"H2O + NAD(+) + prop-2-ynal = 2 H(+) + NADH + propynoate"}
{"X":32821,"RHEA_ID":40846,"compounds":"FAD + H(+) + octadecanoyl-CoA <=> (2E)-octadecenoyl-CoA + FADH2"}
{"X":32822,"RHEA_ID":30881,"compounds":"2 H(+) + NADH + propynoate => H2O + NAD(+) + prop-2-ynal"}
{"X":32823,"RHEA_ID":40849,"compounds":"(2E)-eicosenoyl-CoA + FADH2 => eicosanoyl-CoA + FAD + H(+)"}
{"X":32824,"RHEA_ID":40850,"compounds":"eicosanoyl-CoA + FAD + H(+) <=> (2E)-eicosenoyl-CoA + FADH2"}
{"X":32825,"RHEA_ID":30885,"compounds":"D-glucarate + 3 H(+) + NADH => D-glucurono-3,6-lactone + 2 H2O + NAD(+)"}
{"X":32826,"RHEA_ID":40852,"compounds":"FAD + H(+) + pentadecanoyl-CoA => (2E)-pentadecenoyl-CoA + FADH2"}
{"X":32827,"RHEA_ID":40853,"compounds":"(2E)-pentadecenoyl-CoA + FADH2 => FAD + H(+) + pentadecanoyl-CoA"}
{"X":32828,"RHEA_ID":40854,"compounds":"FAD + H(+) + pentadecanoyl-CoA <=> (2E)-pentadecenoyl-CoA + FADH2"}
{"X":32829,"RHEA_ID":30889,"compounds":"7,8-dihydropteroate + H2O => 4-aminobenzoate + 6-hydroxymethyl-7,8-dihydropterin"}
{"X":32830,"RHEA_ID":40856,"compounds":"FAD + H(+) + undecanoyl-CoA => FADH2 + trans-2-undecenoyl-CoA"}
{"X":32831,"RHEA_ID":40857,"compounds":"FADH2 + trans-2-undecenoyl-CoA => FAD + H(+) + undecanoyl-CoA"}
{"X":32832,"RHEA_ID":40858,"compounds":"FAD + H(+) + undecanoyl-CoA <=> FADH2 + trans-2-undecenoyl-CoA"}
{"X":32833,"RHEA_ID":30893,"compounds":"acetate + H(+) + S-sulfo-L-cysteine => O-acetyl-L-serine + thiosulfate"}
{"X":32834,"RHEA_ID":40860,"compounds":"(9Z)-hexadecenoyl-CoA + FAD + H(+) => (2E,9Z)-hexadecadienoyl-CoA + FADH2"}
{"X":32835,"RHEA_ID":40861,"compounds":"(2E,9Z)-hexadecadienoyl-CoA + FADH2 => (9Z)-hexadecenoyl-CoA + FAD + H(+)"}
{"X":32836,"RHEA_ID":30896,"DIRECTION":"LR","MASTER_ID":30895,"metacyc":"RXN-6381","compounds":"H2O + O2 + propane-1,3-diamine => 3-aminopropanal + H2O2 + NH4(+)"}
{"X":32837,"RHEA_ID":30897,"compounds":"3-aminopropanal + H2O2 + NH4(+) => H2O + O2 + propane-1,3-diamine"}
{"X":32838,"RHEA_ID":30899,"DIRECTION":"UN","MASTER_ID":30899,"ec":"2.4.1.330","compounds":"bis(beta-D-glucosyl) crocetin + UDP-alpha-D-glucose = beta-D-gentiobiosyl beta-D-glucosyl crocetin + H(+) + UDP"}
{"X":32839,"RHEA_ID":40866,"compounds":"FAD + H(+) + heptadecanoyl-CoA <=> FADH2 + trans-2-heptadecenoyl-CoA"}
{"X":32840,"RHEA_ID":30901,"compounds":"beta-D-gentiobiosyl beta-D-glucosyl crocetin + H(+) + UDP => bis(beta-D-glucosyl) crocetin + UDP-alpha-D-glucose"}
{"X":32841,"RHEA_ID":40868,"compounds":"(9E)-octadecenoyl-CoA + FAD + H(+) => (2E,9E)-octadecadienoyl-CoA + FADH2"}
{"X":32842,"RHEA_ID":40869,"compounds":"(2E,9E)-octadecadienoyl-CoA + FADH2 => (9E)-octadecenoyl-CoA + FAD + H(+)"}
{"X":32843,"RHEA_ID":40870,"compounds":"(9E)-octadecenoyl-CoA + FAD + H(+) <=> (2E,9E)-octadecadienoyl-CoA + FADH2"}
{"X":32844,"RHEA_ID":30905,"compounds":"H(+) + S-adenosyl-L-homocysteine + spheroidene => demethylspheroidene + S-adenosyl-L-methionine"}
{"X":32845,"RHEA_ID":40872,"compounds":"(9Z)-octadecenoyl-CoA + FAD + H(+) => (2E,9Z)-octadecadienoyl-CoA + FADH2"}
{"X":32846,"RHEA_ID":30907,"DIRECTION":"UN","MASTER_ID":30907,"ec":"1.2.1.25","compounds":"(S)-3-methyl-2-oxopentanoate + CoA + NAD(+) = 2-methylbutanoyl-CoA + CO2 + NADH"}
{"X":32847,"RHEA_ID":40874,"compounds":"(9Z)-octadecenoyl-CoA + FAD + H(+) <=> (2E,9Z)-octadecadienoyl-CoA + FADH2"}
{"X":32848,"RHEA_ID":30909,"compounds":"2-methylbutanoyl-CoA + CO2 + NADH => (S)-3-methyl-2-oxopentanoate + CoA + NAD(+)"}
{"X":32849,"RHEA_ID":40876,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + FAD + H(+) => (2E,9Z,12Z)-octadecatrienoyl-CoA + FADH2"}
{"X":32850,"RHEA_ID":30911,"DIRECTION":"UN","MASTER_ID":30911,"ec":"3.5.1.109","compounds":"H2O + sphingomyelin = a carboxylate + sphing-4-enine-phosphocholine"}
{"X":32851,"RHEA_ID":40878,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + FAD + H(+) <=> (2E,9Z,12Z)-octadecatrienoyl-CoA + FADH2"}
{"X":32852,"RHEA_ID":30913,"compounds":"a carboxylate + sphing-4-enine-phosphocholine => H2O + sphingomyelin"}
{"X":32853,"RHEA_ID":30914,"compounds":"H2O + sphingomyelin <=> a carboxylate + sphing-4-enine-phosphocholine"}
{"X":32854,"RHEA_ID":40881,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine => 2 1-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":32855,"RHEA_ID":40882,"compounds":"2 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine"}
{"X":32856,"RHEA_ID":30917,"compounds":"a fatty acid + beta-D-glucosyl-(1<->1)-sphing-4-enine => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O"}
{"X":32857,"RHEA_ID":30918,"compounds":"a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O <=> a fatty acid + beta-D-glucosyl-(1<->1)-sphing-4-enine"}
{"X":32858,"RHEA_ID":40885,"compounds":"(2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + FADH2 => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + FAD + H(+)"}
{"X":32859,"RHEA_ID":40886,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + FAD + H(+) <=> (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + FADH2"}
{"X":32860,"RHEA_ID":30921,"compounds":"(3E)-3,4-didehydrorhodopin + AH2 => A + rhodopin"}
{"X":32861,"RHEA_ID":40888,"compounds":"1-octadecanoyl-sn-glycero-3-phosphocholine + H2O => H(+) + octadecanoate + sn-glycerol 3-phosphocholine"}
{"X":32862,"RHEA_ID":30923,"DIRECTION":"UN","MASTER_ID":30923,"ec":"2.4.1.268","compounds":"(R)-glycerate + ADP-alpha-D-glucose = (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + ADP + H(+)"}
{"X":32863,"RHEA_ID":40890,"compounds":"1-octadecanoyl-sn-glycero-3-phosphocholine + H2O <=> H(+) + octadecanoate + sn-glycerol 3-phosphocholine"}
{"X":32864,"RHEA_ID":30925,"compounds":"(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + ADP + H(+) => (R)-glycerate + ADP-alpha-D-glucose"}
{"X":32865,"RHEA_ID":40892,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O => H(+) + hexadecanoate + sn-glycero-3-phosphoethanolamine"}
{"X":32866,"RHEA_ID":40893,"compounds":"H(+) + hexadecanoate + sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O"}
{"X":32867,"RHEA_ID":40894,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O <=> H(+) + hexadecanoate + sn-glycero-3-phosphoethanolamine"}
{"X":32868,"RHEA_ID":30929,"compounds":"5-dehydro-4-deoxy-D-glucuronate + L-rhamnopyranose => 2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnopyranose + H2O"}
{"X":32869,"RHEA_ID":30930,"compounds":"2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnopyranose + H2O <=> 5-dehydro-4-deoxy-D-glucuronate + L-rhamnopyranose"}
{"X":32870,"RHEA_ID":40897,"compounds":"(9Z)-octadecenoate + H(+) + sn-glycero-3-phosphoethanolamine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O"}
{"X":32871,"RHEA_ID":40898,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> (9Z)-octadecenoate + H(+) + sn-glycero-3-phosphoethanolamine"}
{"X":32872,"RHEA_ID":30933,"compounds":"acetate + H(+) + L,L-cystathionine => L-cysteine + O-acetyl-L-homoserine"}
{"X":32873,"RHEA_ID":40900,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine"}
{"X":32874,"RHEA_ID":40901,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":32875,"RHEA_ID":40902,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine"}
{"X":32876,"RHEA_ID":30937,"compounds":"beta-D-ribosylnicotinate + phosphate => H2O + nicotinate beta-D-ribonucleotide"}
{"X":32877,"RHEA_ID":40904,"compounds":"2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => H(+) + hexadecanoate + sn-glycerol 3-phosphocholine"}
{"X":32878,"RHEA_ID":40905,"compounds":"H(+) + hexadecanoate + sn-glycerol 3-phosphocholine => 2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":32879,"RHEA_ID":40906,"compounds":"2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> H(+) + hexadecanoate + sn-glycerol 3-phosphocholine"}
{"X":32880,"RHEA_ID":30941,"compounds":"ADP + dITP => ATP + dIDP"}
{"X":32881,"RHEA_ID":40908,"compounds":"2 2-hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine"}
{"X":32882,"RHEA_ID":40909,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine => 2 2-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":32883,"RHEA_ID":40910,"compounds":"2 2-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine"}
{"X":32884,"RHEA_ID":30945,"compounds":"(2E)-octenoyl-CoA + FADH2 => FAD + H(+) + octanoyl-CoA"}
{"X":32885,"RHEA_ID":40912,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)"}
{"X":32886,"RHEA_ID":40913,"compounds":"(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O"}
{"X":32887,"RHEA_ID":40914,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)"}
{"X":32888,"RHEA_ID":30949,"compounds":"10-epi-gamma-eudesmol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}
{"X":32889,"RHEA_ID":40916,"compounds":"1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":32890,"RHEA_ID":40917,"compounds":"(9Z)-octadecenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) => 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":32891,"RHEA_ID":40918,"compounds":"1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":32892,"RHEA_ID":30953,"compounds":"alpha-eudesmol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}
{"X":32893,"RHEA_ID":40920,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+)"}
{"X":32894,"RHEA_ID":40921,"compounds":"(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O"}
{"X":32895,"RHEA_ID":40922,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+)"}
{"X":32896,"RHEA_ID":30957,"compounds":"7,7',9,9'-tetra-cis-lycopene + 2 a quinol => 9,9'-di-cis-zeta-carotene + 2 a quinone"}
{"X":32897,"RHEA_ID":40924,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)"}
{"X":32898,"RHEA_ID":40925,"compounds":"(9Z)-octadecenoate + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O"}
{"X":32899,"RHEA_ID":40926,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)"}
{"X":32900,"RHEA_ID":30961,"compounds":"7,9,9'-tri-cis-neurosporene + a quinol => 9,9'-di-cis-zeta-carotene + a quinone"}
{"X":32901,"RHEA_ID":40928,"compounds":"1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + H2O => (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycerol + H(+)"}
{"X":32902,"RHEA_ID":30963,"compounds":"7,9,9'-tri-cis-neurosporene + a quinone = 7,7',9,9'-tetra-cis-lycopene + a quinol"}
{"X":32903,"RHEA_ID":40930,"compounds":"1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + H2O <=> (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycerol + H(+)"}
{"X":32904,"RHEA_ID":30965,"compounds":"7,7',9,9'-tetra-cis-lycopene + a quinol => 7,9,9'-tri-cis-neurosporene + a quinone"}
{"X":32905,"RHEA_ID":40932,"compounds":"2-oxoglutarate + L-ornithine + O2 => (3S)-3-hydroxy-L-ornithine + CO2 + succinate"}
{"X":32906,"RHEA_ID":40933,"compounds":"(3S)-3-hydroxy-L-ornithine + CO2 + succinate => 2-oxoglutarate + L-ornithine + O2"}
{"X":32907,"RHEA_ID":40934,"compounds":"2-oxoglutarate + L-ornithine + O2 <=> (3S)-3-hydroxy-L-ornithine + CO2 + succinate"}
{"X":32908,"RHEA_ID":30969,"compounds":"9,9'-di-cis-zeta-carotene => 9,9',15-tri-cis-zeta-carotene"}
{"X":32909,"RHEA_ID":40936,"compounds":"a 1-acylglycerone 3-phosphate + hexadecan-1-ol => 1-O-hexadecylglycerone 3-phosphate + a fatty acid + H(+)"}
{"X":32910,"RHEA_ID":40937,"compounds":"1-O-hexadecylglycerone 3-phosphate + a fatty acid + H(+) => a 1-acylglycerone 3-phosphate + hexadecan-1-ol"}
{"X":32911,"RHEA_ID":30972,"DIRECTION":"LR","MASTER_ID":30971,"metacyc":"RXN-8042","compounds":"7,7',9,9'-tetra-cis-lycopene => all-trans-lycopene"}
{"X":32912,"RHEA_ID":30973,"compounds":"all-trans-lycopene => 7,7',9,9'-tetra-cis-lycopene"}
{"X":32913,"RHEA_ID":40940,"compounds":"1-O-hexadecylglycerone 3-phosphate + H(+) + NADPH => 1-O-hexadecyl-sn-glycero-3-phosphate + NADP(+)"}
{"X":32914,"RHEA_ID":40941,"compounds":"1-O-hexadecyl-sn-glycero-3-phosphate + NADP(+) => 1-O-hexadecylglycerone 3-phosphate + H(+) + NADPH"}
{"X":32915,"RHEA_ID":40942,"compounds":"1-O-hexadecylglycerone 3-phosphate + H(+) + NADPH <=> 1-O-hexadecyl-sn-glycero-3-phosphate + NADP(+)"}
{"X":32916,"RHEA_ID":30977,"compounds":"5 AH2 + all-trans-3,4-didehydrolycopene => 15-cis-phytoene + 5 A"}
{"X":32917,"RHEA_ID":40944,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + hexadecanoate"}
{"X":32918,"RHEA_ID":40945,"compounds":"2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O"}
{"X":32919,"RHEA_ID":30980,"DIRECTION":"LR","MASTER_ID":30979,"metacyc":"RXN-11974","compounds":"A + all-trans-lycopene => AH2 + all-trans-3,4-didehydrolycopene"}
{"X":32920,"RHEA_ID":30981,"compounds":"AH2 + all-trans-3,4-didehydrolycopene => A + all-trans-lycopene"}
{"X":32921,"RHEA_ID":40952,"DIRECTION":"LR","MASTER_ID":40951,"metacyc":"RXN-18396","compounds":"(2S)-2-acetamido-4-aminobutanoate + H2O => acetate + L-2,4-diaminobutanoate"}
{"X":32922,"RHEA_ID":50924,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate"}
{"X":32923,"RHEA_ID":30984,"DIRECTION":"LR","MASTER_ID":30983,"metacyc":"3.2.1.97-RXN","compounds":"H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] => beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-seryl-[protein]"}
{"X":32924,"RHEA_ID":30985,"compounds":"beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-seryl-[protein] => H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein]"}
{"X":32925,"RHEA_ID":40957,"compounds":"ADP + CO2 + isopentenyl phosphate + phosphate => (R)-5-phosphomevalonate + ATP"}
{"X":32926,"RHEA_ID":50929,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 => (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate"}
{"X":32927,"RHEA_ID":30989,"compounds":"(17Z)-protosta-17(20),24-dien-3beta-ol => (S)-2,3-epoxysqualene"}
{"X":32928,"RHEA_ID":40960,"compounds":"2 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine => 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine"}
{"X":32929,"RHEA_ID":40961,"compounds":"1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine => 2 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine"}
{"X":32930,"RHEA_ID":30992,"DIRECTION":"LR","MASTER_ID":30991,"metacyc":"RXN-8082","compounds":"beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => 24-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":32931,"RHEA_ID":30993,"compounds":"24-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":32932,"RHEA_ID":40964,"DIRECTION":"LR","MASTER_ID":40963,"metacyc":"O-AMINOPHENOL-OXIDASE-RXN","compounds":"4 2-aminophenol + 3 O2 => 2 2-aminophenoxazin-3-one + 6 H2O"}
{"X":32933,"RHEA_ID":40965,"compounds":"2 2-aminophenoxazin-3-one + 6 H2O => 4 2-aminophenol + 3 O2"}
{"X":32934,"RHEA_ID":50937,"compounds":"2-oxoglutarate + 3-aminobutanoyl-CoA => acetoacetyl-CoA + L-glutamate"}
{"X":32935,"RHEA_ID":30997,"compounds":"H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + soyasapogenol B => O2 + reduced [NADPH--hemoprotein reductase] + sophoradiol"}
{"X":32936,"RHEA_ID":40968,"compounds":"1,2-di-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-glycerol + H(+)"}
{"X":32937,"RHEA_ID":40969,"compounds":"(9Z)-octadecenoate + 1-(9Z-octadecenoyl)-glycerol + H(+) => 1,2-di-(9Z-octadecenoyl)-glycerol + H2O"}
{"X":32938,"RHEA_ID":31000,"compounds":"(S)-2,3-epoxysqualene => cucurbitadienol"}
{"X":32939,"RHEA_ID":31001,"compounds":"cucurbitadienol => (S)-2,3-epoxysqualene"}
{"X":32940,"RHEA_ID":40972,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O => 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":32941,"RHEA_ID":40973,"compounds":"2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O"}
{"X":32942,"RHEA_ID":40974,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":32943,"RHEA_ID":31005,"compounds":"germanicol => (S)-2,3-epoxysqualene"}
{"X":32944,"RHEA_ID":40976,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2 H2O => 2 H(+) + 2 hexadecanoate + sn-glycerol 3-phosphocholine"}
{"X":32945,"RHEA_ID":40977,"compounds":"2 H(+) + 2 hexadecanoate + sn-glycerol 3-phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2 H2O"}
{"X":32946,"RHEA_ID":40978,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2 H2O <=> 2 H(+) + 2 hexadecanoate + sn-glycerol 3-phosphocholine"}
{"X":32947,"RHEA_ID":31009,"compounds":"beta-amyrin => (S)-2,3-epoxysqualene"}
{"X":32948,"RHEA_ID":31010,"compounds":"(S)-2,3-epoxysqualene <=> beta-amyrin"}
{"X":32949,"RHEA_ID":40981,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)glycerol + H(+) + hexadecanoate => 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O"}
{"X":32950,"RHEA_ID":40982,"compounds":"1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)glycerol + H(+) + hexadecanoate"}
{"X":32951,"RHEA_ID":31013,"compounds":"camelliol C => (S)-2,3-epoxysqualene"}
{"X":32952,"RHEA_ID":40984,"compounds":"1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O => (9Z)-octadecenoate + 1,3-dihexadecanoylglycerol + H(+)"}
{"X":32953,"RHEA_ID":40985,"compounds":"(9Z)-octadecenoate + 1,3-dihexadecanoylglycerol + H(+) => 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O"}
{"X":32954,"RHEA_ID":31016,"compounds":"H(+) + indole-3-carboxylate => CO2 + indole"}
{"X":32955,"RHEA_ID":31017,"compounds":"CO2 + indole => H(+) + indole-3-carboxylate"}
{"X":32956,"RHEA_ID":40988,"compounds":"EDTA + 2 FMNH2 + 2 O2 => ethylenediaminediacetate + 2 FMN + 2 glyoxylate + 3 H(+) + 2 H2O"}
{"X":32957,"RHEA_ID":31019,"DIRECTION":"UN","MASTER_ID":31019,"ec":"1.14.99.44","compounds":"4 AH2 + all-trans-4,4'-diapolycopene + 4 O2 = 4 A + all-trans-4,4'-diapolycopene-4,4'-dial + 6 H2O"}
{"X":32958,"RHEA_ID":50961,"DIRECTION":"LR","MASTER_ID":50960,"metacyc":"RXN-13998","compounds":"cytidine(32) in tRNA(Thr) + S-adenosyl-L-methionine => H(+) + N(3)-methylcytidine(32) in tRNA(Thr) + S-adenosyl-L-homocysteine"}
{"X":32959,"RHEA_ID":40991,"compounds":"(E)-4-coumaroyl-CoA + H2O = 3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA"}
{"X":32960,"RHEA_ID":40992,"DIRECTION":"LR","MASTER_ID":40991,"metacyc":"RXN-11244","compounds":"(E)-4-coumaroyl-CoA + H2O => 3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA"}
{"X":32961,"RHEA_ID":31023,"DIRECTION":"UN","MASTER_ID":31023,"ec":"5.4.99.37","compounds":"squalene = dammara-20,24-diene"}
{"X":32962,"RHEA_ID":40994,"compounds":"(E)-4-coumaroyl-CoA + H2O <=> 3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA"}
{"X":32963,"RHEA_ID":40995,"compounds":"3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA = 4-hydroxybenzaldehyde + acetyl-CoA"}
{"X":32964,"RHEA_ID":40996,"DIRECTION":"LR","MASTER_ID":40995,"metacyc":"RXN-13392","compounds":"3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA => 4-hydroxybenzaldehyde + acetyl-CoA"}
{"X":32965,"RHEA_ID":31027,"DIRECTION":"UN","MASTER_ID":31027,"ec":"2.4.1.263","compounds":"2-trans-(+)-abscisate + UDP-alpha-D-glucose = beta-D-glucopyranosyl trans-(+)-abscisate + UDP"}
{"X":32966,"RHEA_ID":40998,"compounds":"3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA <=> 4-hydroxybenzaldehyde + acetyl-CoA"}
{"X":32967,"RHEA_ID":31029,"compounds":"beta-D-glucopyranosyl trans-(+)-abscisate + UDP => 2-trans-(+)-abscisate + UDP-alpha-D-glucose"}
{"X":32968,"RHEA_ID":31030,"compounds":"2-trans-(+)-abscisate + UDP-alpha-D-glucose <=> beta-D-glucopyranosyl trans-(+)-abscisate + UDP"}
{"X":32969,"RHEA_ID":31031,"DIRECTION":"UN","MASTER_ID":31031,"ec":"2.4.1.263","compounds":"2-cis-(+)-abscisate + UDP-alpha-D-glucose = beta-D-glucopyranosyl cis-(+)-abscisate + UDP"}
{"X":32970,"RHEA_ID":41002,"compounds":"1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-tetradecanoyl-sn-glycerol + H(+) + phosphocholine"}
{"X":32971,"RHEA_ID":41003,"compounds":"1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H(+) + phosphocholine"}
{"X":32972,"RHEA_ID":41004,"compounds":"1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H(+) + phosphocholine"}
{"X":32973,"RHEA_ID":31035,"DIRECTION":"UN","MASTER_ID":31035,"ec":"4.2.1.124","compounds":"arabidiol = (S)-2,3-epoxysqualene + H2O"}
{"X":32974,"RHEA_ID":41006,"compounds":"1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H(+) + phosphocholine"}
{"X":32975,"RHEA_ID":41007,"DIRECTION":"UN","MASTER_ID":41007,"ec":"2.5.1.124","compounds":"(2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin = 6-linalyl-2-O,3-dimethylflaviolin + diphosphate"}
{"X":32976,"RHEA_ID":41008,"compounds":"(2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin => 6-linalyl-2-O,3-dimethylflaviolin + diphosphate"}
{"X":32977,"RHEA_ID":31039,"compounds":"dodecanoyl-CoA + FAD + H(+) = (2E)-dodecenoyl-CoA + FADH2"}
{"X":32978,"RHEA_ID":31040,"DIRECTION":"LR","MASTER_ID":31039,"reactome":"R-HSA-77263.2","compounds":"dodecanoyl-CoA + FAD + H(+) => (2E)-dodecenoyl-CoA + FADH2"}
{"X":32979,"RHEA_ID":41011,"DIRECTION":"UN","MASTER_ID":41011,"ec":"2.1.5.1","compounds":"(+)-sesamin + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n = (+)-sesamin monocatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n)"}
{"X":32980,"RHEA_ID":41012,"DIRECTION":"LR","MASTER_ID":41011,"metacyc":"RXN-18465","compounds":"(+)-sesamin + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n => (+)-sesamin monocatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n)"}
{"X":32981,"RHEA_ID":31043,"compounds":"(S)-methylmalonate semialdehyde + H2O + NAD(+) = 2 H(+) + methylmalonate + NADH"}
{"X":32982,"RHEA_ID":50985,"compounds":"prostaglandin E2(out) => prostaglandin E2(in)"}
{"X":32983,"RHEA_ID":41015,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol = 1-O-hexadecyl-2-acetyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA"}
{"X":32984,"RHEA_ID":41016,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol => 1-O-hexadecyl-2-acetyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA"}
{"X":32985,"RHEA_ID":31047,"compounds":"(S)-methylmalonate semialdehyde + CoA + NAD(+) = CO2 + NADH + propanoyl-CoA"}
{"X":32986,"RHEA_ID":31048,"compounds":"(S)-methylmalonate semialdehyde + CoA + NAD(+) => CO2 + NADH + propanoyl-CoA"}
{"X":32987,"RHEA_ID":31049,"compounds":"CO2 + NADH + propanoyl-CoA => (S)-methylmalonate semialdehyde + CoA + NAD(+)"}
{"X":32988,"RHEA_ID":41020,"compounds":"(9Z)-octadecenoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol => 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA"}
{"X":32989,"RHEA_ID":31051,"compounds":"(3R)-beta-leucine + H2O + NAD(+) = 3-oxo-4-methylpentanoate + H(+) + NADH + NH4(+)"}
{"X":32990,"RHEA_ID":41022,"compounds":"(9Z)-octadecenoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol <=> 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA"}
{"X":32991,"RHEA_ID":31053,"compounds":"3-oxo-4-methylpentanoate + H(+) + NADH + NH4(+) => (3R)-beta-leucine + H2O + NAD(+)"}
{"X":32992,"RHEA_ID":31055,"compounds":"estrone 3-sulfate + H2O = estrone + H(+) + sulfate"}
{"X":32993,"RHEA_ID":31056,"compounds":"estrone 3-sulfate + H2O => estrone + H(+) + sulfate"}
{"X":32994,"RHEA_ID":41027,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycerol + tetradecanoyl-CoA = 1-O-hexadecyl-2-acetyl-3-tetradecanoyl-sn-glycerol + CoA"}
{"X":32995,"RHEA_ID":41028,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycerol + tetradecanoyl-CoA => 1-O-hexadecyl-2-acetyl-3-tetradecanoyl-sn-glycerol + CoA"}
{"X":32996,"RHEA_ID":31059,"compounds":"H2O + imidazole-4-acetaldehyde + NAD(+) = 2 H(+) + imidazole-4-acetate + NADH"}
{"X":32997,"RHEA_ID":31060,"DIRECTION":"LR","MASTER_ID":31059,"metacyc":"RXN-10089","compounds":"H2O + imidazole-4-acetaldehyde + NAD(+) => 2 H(+) + imidazole-4-acetate + NADH"}
{"X":32998,"RHEA_ID":31061,"compounds":"2 H(+) + imidazole-4-acetate + NADH => H2O + imidazole-4-acetaldehyde + NAD(+)"}
{"X":32999,"RHEA_ID":41032,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycerol + decanoyl-CoA => 1-O-hexadecyl-2-acetyl-3-decanoyl-sn-glycerol + CoA"}
{"X":33000,"RHEA_ID":31063,"DIRECTION":"UN","MASTER_ID":31063,"ec":"1.3.8.4","compounds":"3-methylbutanoyl-CoA + FAD + H(+) = 3-methylbut-2-enoyl-CoA + FADH2"}
{"X":33001,"RHEA_ID":41034,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycerol + decanoyl-CoA <=> 1-O-hexadecyl-2-acetyl-3-decanoyl-sn-glycerol + CoA"}
{"X":33002,"RHEA_ID":41035,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycerol + hexadecanoyl-CoA = 1-O-hexadecyl-2-acetyl-3-hexadecanoyl-sn-glycerol + CoA"}
{"X":33003,"RHEA_ID":41036,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycerol + hexadecanoyl-CoA => 1-O-hexadecyl-2-acetyl-3-hexadecanoyl-sn-glycerol + CoA"}
{"X":33004,"RHEA_ID":31067,"compounds":"6-amino-2-oxohexanoate = Delta(1)-piperideine-2-carboxylate + H2O"}
{"X":33005,"RHEA_ID":41038,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycerol + hexadecanoyl-CoA <=> 1-O-hexadecyl-2-acetyl-3-hexadecanoyl-sn-glycerol + CoA"}
{"X":33006,"RHEA_ID":31069,"compounds":"Delta(1)-piperideine-2-carboxylate + H2O => 6-amino-2-oxohexanoate"}
{"X":33007,"RHEA_ID":41040,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycerol + dodecanoyl-CoA => 1-O-hexadecyl-2-acetyl-3-dodecanoyl-sn-glycerol + CoA"}
{"X":33008,"RHEA_ID":31071,"compounds":"(S)-methylmalonate semialdehyde + L-alanine = (S)-3-amino-2-methylpropanoate + pyruvate"}
{"X":33009,"RHEA_ID":31072,"compounds":"(S)-methylmalonate semialdehyde + L-alanine => (S)-3-amino-2-methylpropanoate + pyruvate"}
{"X":33010,"RHEA_ID":41043,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycerol + octanoyl-CoA = 1-O-hexadecyl-2-acetyl-3-octanoyl-sn-glycerol + CoA"}
{"X":33011,"RHEA_ID":41044,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycerol + octanoyl-CoA => 1-O-hexadecyl-2-acetyl-3-octanoyl-sn-glycerol + CoA"}
{"X":33012,"RHEA_ID":31075,"compounds":"(3S)-hydroxydodecanoyl-CoA = (2E)-dodecenoyl-CoA + H2O"}
{"X":33013,"RHEA_ID":41046,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycerol + octanoyl-CoA <=> 1-O-hexadecyl-2-acetyl-3-octanoyl-sn-glycerol + CoA"}
{"X":33014,"RHEA_ID":31077,"DIRECTION":"RL","MASTER_ID":31075,"reactome":"R-HSA-77256.2","compounds":"(2E)-dodecenoyl-CoA + H2O => (3S)-hydroxydodecanoyl-CoA"}
{"X":33015,"RHEA_ID":51018,"compounds":"6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde phosphate => 7,8-dihydroneopterin 3'-phosphate"}
{"X":33016,"RHEA_ID":31079,"compounds":"3-hydroxyisovaleryl-CoA = 3-methylbut-2-enoyl-CoA + H2O"}
{"X":33017,"RHEA_ID":41050,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol <=> 1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA"}
{"X":33018,"RHEA_ID":31081,"compounds":"3-methylbut-2-enoyl-CoA + H2O => 3-hydroxyisovaleryl-CoA"}
{"X":33019,"RHEA_ID":51022,"compounds":"2 [Fe(II)cytochrome c] + an aldehyde + 2 H(+) => 2 [Fe(III)cytochrome c] + a primary alcohol"}
{"X":33020,"RHEA_ID":31083,"compounds":"H2O + N-acetyl-D-muramoyl-L-alanine = L-alanine + N-acetyl-D-muramate"}
{"X":33021,"RHEA_ID":31084,"compounds":"H2O + N-acetyl-D-muramoyl-L-alanine => L-alanine + N-acetyl-D-muramate"}
{"X":33022,"RHEA_ID":31085,"compounds":"L-alanine + N-acetyl-D-muramate => H2O + N-acetyl-D-muramoyl-L-alanine"}
{"X":33023,"RHEA_ID":51026,"compounds":"4-(hydroxymethyl)benzenesulfonate + H2O + NAD(+) => H(+) + NADH + O2 + toluene-4-sulfonate"}
{"X":33024,"RHEA_ID":31087,"compounds":"acetyl-CoA + octanoyl-CoA = 3-oxodecanoyl-CoA + CoA"}
{"X":33025,"RHEA_ID":41058,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + dodecanoyl-CoA <=> 1,2-di-(9Z)-octadecenoyl-3-dodecanoyl-sn-glycerol + CoA"}
{"X":33026,"RHEA_ID":31089,"DIRECTION":"RL","MASTER_ID":31087,"reactome":"R-HSA-77340.2","compounds":"3-oxodecanoyl-CoA + CoA => acetyl-CoA + octanoyl-CoA"}
{"X":33027,"RHEA_ID":51030,"compounds":"7-chloroindole-3-pyruvate imine dimer + 2 H2O => 2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2"}
{"X":33028,"RHEA_ID":31091,"compounds":"acetyl-CoA + dodecanoyl-CoA = 3-oxotetradecanoyl-CoA + CoA"}
{"X":33029,"RHEA_ID":41062,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + octadecanoyl-CoA <=> 1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + CoA"}
{"X":33030,"RHEA_ID":31093,"DIRECTION":"RL","MASTER_ID":31091,"reactome":"R-HSA-77271.2","compounds":"3-oxotetradecanoyl-CoA + CoA => acetyl-CoA + dodecanoyl-CoA"}
{"X":33031,"RHEA_ID":41064,"compounds":"1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O => 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":33032,"RHEA_ID":31095,"DIRECTION":"UN","MASTER_ID":31095,"ec":"1.3.99.12","compounds":"2-methylpropanoyl-CoA + A = (2E)-2-methylpropenoyl-CoA + AH2"}
{"X":33033,"RHEA_ID":41066,"compounds":"1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":33034,"RHEA_ID":31097,"compounds":"(2E)-2-methylpropenoyl-CoA + AH2 => 2-methylpropanoyl-CoA + A"}
{"X":33035,"RHEA_ID":51038,"compounds":"2 H2O + indole-3-pyruvate imine dimer => 2 2-iminio-3-(indol-3-yl)propanoate + H2O2"}
{"X":33036,"RHEA_ID":31099,"compounds":"2-methylpropanoyl-CoA + FAD + H(+) = (2E)-2-methylpropenoyl-CoA + FADH2"}
{"X":33037,"RHEA_ID":41070,"compounds":"1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":33038,"RHEA_ID":31101,"compounds":"(2E)-2-methylpropenoyl-CoA + FADH2 => 2-methylpropanoyl-CoA + FAD + H(+)"}
{"X":33039,"RHEA_ID":41072,"compounds":"1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":33040,"RHEA_ID":31103,"compounds":"7,8-dihydrofolate + NADP(+) = folate + H(+) + NADPH"}
{"X":33041,"RHEA_ID":41074,"compounds":"1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":33042,"RHEA_ID":31105,"DIRECTION":"RL","MASTER_ID":31103,"reactome":"R-HSA-197963.1","compounds":"folate + H(+) + NADPH => 7,8-dihydrofolate + NADP(+)"}
{"X":33043,"RHEA_ID":41076,"compounds":"1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+)"}
{"X":33044,"RHEA_ID":31107,"compounds":"3-phenylpyruvate + O2 = (2-hydroxyphenyl)acetate + CO2"}
{"X":33045,"RHEA_ID":41078,"compounds":"1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+)"}
{"X":33046,"RHEA_ID":31109,"compounds":"(2-hydroxyphenyl)acetate + CO2 => 3-phenylpyruvate + O2"}
{"X":33047,"RHEA_ID":51050,"compounds":"AH2 + androst-4-ene-3,17-dione => 5alpha-androstan-3,17-dione + A"}
{"X":33048,"RHEA_ID":31111,"compounds":"acetyl-CoA + butanoyl-CoA = 3-oxohexanoyl-CoA + CoA"}
{"X":33049,"RHEA_ID":31112,"compounds":"acetyl-CoA + butanoyl-CoA => 3-oxohexanoyl-CoA + CoA"}
{"X":33050,"RHEA_ID":41083,"compounds":"1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":33051,"RHEA_ID":41084,"compounds":"1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O => (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":33052,"RHEA_ID":31115,"compounds":"ATP + biotin + H(+) = biotinyl-5'-AMP + diphosphate"}
{"X":33053,"RHEA_ID":31116,"DIRECTION":"LR","MASTER_ID":31115,"ecocyc":"RXN0-7192","metacyc":"RXN0-7192","compounds":"ATP + biotin + H(+) => biotinyl-5'-AMP + diphosphate"}
{"X":33054,"RHEA_ID":31117,"compounds":"biotinyl-5'-AMP + diphosphate => ATP + biotin + H(+)"}
{"X":33055,"RHEA_ID":51058,"compounds":"AH2 + androsta-1,4-diene-3,17-dione => A + androst-4-ene-3,17-dione"}
{"X":33056,"RHEA_ID":31119,"compounds":"(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA = (2E)-2-methylbutenoyl-CoA + H2O"}
{"X":33057,"RHEA_ID":31120,"compounds":"(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA => (2E)-2-methylbutenoyl-CoA + H2O"}
{"X":33058,"RHEA_ID":31121,"DIRECTION":"RL","MASTER_ID":31119,"reactome":"R-HSA-70830.2","compounds":"(2E)-2-methylbutenoyl-CoA + H2O => (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA"}
{"X":33059,"RHEA_ID":61300,"compounds":"5-deoxy-D-ribulose 1-phosphate = acetaldehyde + dihydroxyacetone phosphate"}
{"X":33060,"RHEA_ID":31123,"compounds":"muconolactone = (4,5-dihydro-5-oxofuran-2-yl)-acetate"}
{"X":33061,"RHEA_ID":31124,"DIRECTION":"LR","MASTER_ID":31123,"metacyc":"MUCONOLACTONE-DELTA-ISOMERASE-RXN","compounds":"muconolactone => (4,5-dihydro-5-oxofuran-2-yl)-acetate"}
{"X":33062,"RHEA_ID":31125,"compounds":"(4,5-dihydro-5-oxofuran-2-yl)-acetate => muconolactone"}
{"X":33063,"RHEA_ID":41096,"compounds":"H2O + sphing-4-enine-phosphocholine => H(+) + phosphocholine + sphing-4-enine"}
{"X":33064,"RHEA_ID":41097,"compounds":"H(+) + phosphocholine + sphing-4-enine => H2O + sphing-4-enine-phosphocholine"}
{"X":33065,"RHEA_ID":31128,"DIRECTION":"LR","MASTER_ID":31127,"metacyc":"METHYLGALLATE-RXN","compounds":"3-O-methylgallate + O2 => 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + methanol"}
{"X":33066,"RHEA_ID":31129,"compounds":"2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + methanol => 3-O-methylgallate + O2"}
{"X":33067,"RHEA_ID":41100,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine"}
{"X":33068,"RHEA_ID":41101,"compounds":"1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol"}
{"X":33069,"RHEA_ID":31132,"compounds":"5,10-methenyltetrahydrofolate + H2O + N(1)-(5-phospho-D-ribosyl)glycinamide => (6S)-5,6,7,8-tetrahydrofolate + 2 H(+) + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide"}
{"X":33070,"RHEA_ID":31133,"compounds":"(6S)-5,6,7,8-tetrahydrofolate + 2 H(+) + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide => 5,10-methenyltetrahydrofolate + H2O + N(1)-(5-phospho-D-ribosyl)glycinamide"}
{"X":33071,"RHEA_ID":41104,"compounds":"1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-3-octadecanoyl-sn-glycerol + H(+)"}
{"X":33072,"RHEA_ID":61313,"DIRECTION":"LR","MASTER_ID":61312,"metacyc":"RXN-8969","compounds":"germacra-1(10),4,11(13)-trien-12-ol + O2 + reduced [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":33073,"RHEA_ID":31136,"compounds":"5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + diphosphate => 5-amino-4-imidazolecarboxyamide + 5-phospho-alpha-D-ribose 1-diphosphate"}
{"X":33074,"RHEA_ID":31137,"compounds":"5-amino-4-imidazolecarboxyamide + 5-phospho-alpha-D-ribose 1-diphosphate => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + diphosphate"}
{"X":33075,"RHEA_ID":41108,"compounds":"1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O => 2-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerol + H(+) + hexadecanoate"}
{"X":33076,"RHEA_ID":31139,"compounds":"(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = 3-hydroxy-3-methyl-2-oxobutanoate + H(+) + NADPH"}
{"X":33077,"RHEA_ID":31140,"compounds":"(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) => 3-hydroxy-3-methyl-2-oxobutanoate + H(+) + NADPH"}
{"X":33078,"RHEA_ID":31141,"compounds":"3-hydroxy-3-methyl-2-oxobutanoate + H(+) + NADPH => (2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+)"}
{"X":33079,"RHEA_ID":41112,"compounds":"1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H(+) + octadecanoate"}
{"X":33080,"RHEA_ID":41113,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H(+) + octadecanoate => 1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O"}
{"X":33081,"RHEA_ID":31144,"DIRECTION":"LR","MASTER_ID":31143,"reactome":"R-HSA-77323.2","compounds":"(3S)-hydroxyhexanoyl-CoA + NAD(+) => 3-oxohexanoyl-CoA + H(+) + NADH"}
{"X":33082,"RHEA_ID":31145,"compounds":"3-oxohexanoyl-CoA + H(+) + NADH => (3S)-hydroxyhexanoyl-CoA + NAD(+)"}
{"X":33083,"RHEA_ID":41116,"compounds":"1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O => 1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H(+) + phosphocholine"}
{"X":33084,"RHEA_ID":41117,"compounds":"1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H(+) + phosphocholine => 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":33085,"RHEA_ID":31148,"compounds":"3,4-dihydroxyphenylethyleneglycol + NAD(+) => 3,4-dihydroxymandelaldehyde + H(+) + NADH"}
{"X":33086,"RHEA_ID":31149,"DIRECTION":"RL","MASTER_ID":31147,"metacyc":"RXN-10911","compounds":"3,4-dihydroxymandelaldehyde + H(+) + NADH => 3,4-dihydroxyphenylethyleneglycol + NAD(+)"}
{"X":33087,"RHEA_ID":41120,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycerol + H(+) + phosphocholine"}
{"X":33088,"RHEA_ID":41121,"compounds":"1-hexadecanoyl-sn-glycerol + H(+) + phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":33089,"RHEA_ID":31152,"DIRECTION":"LR","MASTER_ID":31151,"reactome":"R-HSA-2408543.2","compounds":"H2O + L-selenocystathionine => 2-oxobutanoate + L-selenocysteine + NH4(+)"}
{"X":33090,"RHEA_ID":31153,"compounds":"2-oxobutanoate + L-selenocysteine + NH4(+) => H2O + L-selenocystathionine"}
{"X":33091,"RHEA_ID":51094,"compounds":"10,11-epoxy-(4Z,7Z,13Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":33092,"RHEA_ID":41125,"compounds":"(9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O"}
{"X":33093,"RHEA_ID":31156,"DIRECTION":"LR","MASTER_ID":31155,"metacyc":"HYDROXYPYRROLINEDEH-RXN","compounds":"(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NAD(+) => erythro-4-hydroxy-L-glutamate + H(+) + NADH"}
{"X":33094,"RHEA_ID":31157,"compounds":"erythro-4-hydroxy-L-glutamate + H(+) + NADH => (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NAD(+)"}
{"X":33095,"RHEA_ID":51098,"compounds":"19,20-epoxy-(7Z,10Z,13Z,16Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":33096,"RHEA_ID":41129,"compounds":"1-dodecanoyl-sn-glycerol + H(+) + phosphocholine => 1-dodecanoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":33097,"RHEA_ID":31160,"DIRECTION":"LR","MASTER_ID":31159,"reactome":"R-HSA-77303.2","compounds":"(3S)-hydroxyhexadecanoyl-CoA + NAD(+) => 3-oxohexadecanoyl-CoA + H(+) + NADH"}
{"X":33098,"RHEA_ID":31161,"compounds":"3-oxohexadecanoyl-CoA + H(+) + NADH => (3S)-hydroxyhexadecanoyl-CoA + NAD(+)"}
{"X":33099,"RHEA_ID":41132,"compounds":"1-decanoyl-sn-glycero-3-phosphocholine + H2O => 1-decanoyl-sn-glycero-3-phosphate + choline + H(+)"}
{"X":33100,"RHEA_ID":41133,"compounds":"1-decanoyl-sn-glycero-3-phosphate + choline + H(+) => 1-decanoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":33101,"RHEA_ID":31164,"compounds":"(3S)-hydroxyhexadecanoyl-CoA => (2E)-hexadecenoyl-CoA + H2O"}
{"X":33102,"RHEA_ID":31165,"DIRECTION":"RL","MASTER_ID":31163,"reactome":"R-HSA-77301.2","compounds":"(2E)-hexadecenoyl-CoA + H2O => (3S)-hydroxyhexadecanoyl-CoA"}
{"X":33103,"RHEA_ID":41136,"compounds":"1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O => 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + choline + H(+)"}
{"X":33104,"RHEA_ID":31167,"compounds":"(3S)-hydroxytetradecanoyl-CoA + NAD(+) = 3-oxotetradecanoyl-CoA + H(+) + NADH"}
{"X":33105,"RHEA_ID":31168,"DIRECTION":"LR","MASTER_ID":31167,"reactome":"R-HSA-77283.2","compounds":"(3S)-hydroxytetradecanoyl-CoA + NAD(+) => 3-oxotetradecanoyl-CoA + H(+) + NADH"}
{"X":33106,"RHEA_ID":31169,"compounds":"3-oxotetradecanoyl-CoA + H(+) + NADH => (3S)-hydroxytetradecanoyl-CoA + NAD(+)"}
{"X":33107,"RHEA_ID":51110,"compounds":"10,11-epoxy-(7Z,13Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":33108,"RHEA_ID":41141,"compounds":"1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+) => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O"}
{"X":33109,"RHEA_ID":31172,"compounds":"(3S)-hydroxytetradecanoyl-CoA => (2E)-tetradecenoyl-CoA + H2O"}
{"X":33110,"RHEA_ID":31173,"DIRECTION":"RL","MASTER_ID":31171,"reactome":"R-HSA-77277.2","compounds":"(2E)-tetradecenoyl-CoA + H2O => (3S)-hydroxytetradecanoyl-CoA"}
{"X":33111,"RHEA_ID":51114,"compounds":"20-hydroxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":33112,"RHEA_ID":41145,"compounds":"1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+) => 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O"}
{"X":33113,"RHEA_ID":31176,"DIRECTION":"LR","MASTER_ID":31175,"reactome":"R-HSA-70870.2","compounds":"(2E)-2-methylpropenoyl-CoA + H2O => (S)-3-hydroxyisobutanoyl-CoA"}
{"X":33114,"RHEA_ID":31177,"compounds":"(S)-3-hydroxyisobutanoyl-CoA => (2E)-2-methylpropenoyl-CoA + H2O"}
{"X":33115,"RHEA_ID":41148,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}
{"X":33116,"RHEA_ID":51119,"compounds":"guanosine(6) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(6) in tRNA + S-adenosyl-L-homocysteine"}
{"X":33117,"RHEA_ID":31180,"DIRECTION":"LR","MASTER_ID":31179,"reactome":"R-HSA-77254.2","compounds":"(3S)-hydroxydodecanoyl-CoA + NAD(+) => 3-oxododecanoyl-CoA + H(+) + NADH"}
{"X":33118,"RHEA_ID":31181,"compounds":"3-oxododecanoyl-CoA + H(+) + NADH => (3S)-hydroxydodecanoyl-CoA + NAD(+)"}
{"X":33119,"RHEA_ID":41152,"compounds":"1-hexadecanoyl-2-[9-hydroperoxy-(10E-octadecenoyl)]-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-hydroperoxy-10E-octadecenoate + H(+)"}
{"X":33120,"RHEA_ID":31183,"compounds":"acetyl-CoA + decanoyl-CoA = 3-oxododecanoyl-CoA + CoA"}
{"X":33121,"RHEA_ID":31184,"compounds":"acetyl-CoA + decanoyl-CoA => 3-oxododecanoyl-CoA + CoA"}
{"X":33122,"RHEA_ID":41155,"compounds":"1-hexadecanoyl-2-(10-hydroperoxy-8E-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 10-hydroperoxy-8E-octadecenoate + H(+)"}
{"X":33123,"RHEA_ID":41156,"compounds":"1-hexadecanoyl-2-(10-hydroperoxy-8E-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 10-hydroperoxy-8E-octadecenoate + H(+)"}
{"X":33124,"RHEA_ID":31187,"compounds":"(3S)-hydroxydecanoyl-CoA + NAD(+) = 3-oxodecanoyl-CoA + H(+) + NADH"}
{"X":33125,"RHEA_ID":31188,"DIRECTION":"LR","MASTER_ID":31187,"reactome":"R-HSA-77342.2","compounds":"(3S)-hydroxydecanoyl-CoA + NAD(+) => 3-oxodecanoyl-CoA + H(+) + NADH"}
{"X":33126,"RHEA_ID":41159,"compounds":"1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + glutarate + H(+)"}
{"X":33127,"RHEA_ID":41160,"compounds":"1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + glutarate + H(+)"}
{"X":33128,"RHEA_ID":31191,"compounds":"(3S)-hydroxydecanoyl-CoA = (2E)-decenoyl-CoA + H2O"}
{"X":33129,"RHEA_ID":31192,"compounds":"(3S)-hydroxydecanoyl-CoA => (2E)-decenoyl-CoA + H2O"}
{"X":33130,"RHEA_ID":41163,"compounds":"1-O-hexadecyl-2-amino-sn-glycerol + ATP = 1-O-hexadecyl-2-desoxy-2-amino-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":33131,"RHEA_ID":41164,"compounds":"1-O-hexadecyl-2-amino-sn-glycerol + ATP => 1-O-hexadecyl-2-desoxy-2-amino-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":33132,"RHEA_ID":41165,"compounds":"1-O-hexadecyl-2-desoxy-2-amino-sn-glycero-3-phosphate + ADP + H(+) => 1-O-hexadecyl-2-amino-sn-glycerol + ATP"}
{"X":33133,"RHEA_ID":31196,"DIRECTION":"LR","MASTER_ID":31195,"reactome":"R-HSA-77331.2","compounds":"(3S)-hydroxyoctanoyl-CoA + NAD(+) => 3-oxooctanoyl-CoA + H(+) + NADH"}
{"X":33134,"RHEA_ID":41167,"compounds":"a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)"}
{"X":33135,"RHEA_ID":41168,"compounds":"a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)"}
{"X":33136,"RHEA_ID":41169,"compounds":"2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+) => a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O"}
{"X":33137,"RHEA_ID":31200,"compounds":"(3S)-hydroxyoctanoyl-CoA => (2E)-octenoyl-CoA + H2O"}
{"X":33138,"RHEA_ID":41171,"compounds":"1-acyl-2-hexadecenoyl-sn-glycero-3-phosphate + H2O = 2-hexadecenoyl-sn-glycero-3-phosphate + a fatty acid + H(+)"}
{"X":33139,"RHEA_ID":41172,"compounds":"1-acyl-2-hexadecenoyl-sn-glycero-3-phosphate + H2O => 2-hexadecenoyl-sn-glycero-3-phosphate + a fatty acid + H(+)"}
{"X":33140,"RHEA_ID":41173,"compounds":"2-hexadecenoyl-sn-glycero-3-phosphate + a fatty acid + H(+) => 1-acyl-2-hexadecenoyl-sn-glycero-3-phosphate + H2O"}
{"X":33141,"RHEA_ID":31204,"compounds":"acetyl-CoA + hexanoyl-CoA => 3-oxooctanoyl-CoA + CoA"}
{"X":33142,"RHEA_ID":41175,"DIRECTION":"UN","MASTER_ID":41175,"ec":"2.1.1.249","compounds":"[Co(I) dimethylamine-specific corrinoid protein] + dimethylamine + H(+) = [methyl-Co(III) dimethylamine-specific corrinoid protein] + methylamine"}
{"X":33143,"RHEA_ID":41176,"DIRECTION":"LR","MASTER_ID":41175,"metacyc":"RXN-8100","compounds":"[Co(I) dimethylamine-specific corrinoid protein] + dimethylamine + H(+) => [methyl-Co(III) dimethylamine-specific corrinoid protein] + methylamine"}
{"X":33144,"RHEA_ID":41177,"compounds":"[methyl-Co(III) dimethylamine-specific corrinoid protein] + methylamine => [Co(I) dimethylamine-specific corrinoid protein] + dimethylamine + H(+)"}
{"X":33145,"RHEA_ID":31208,"DIRECTION":"LR","MASTER_ID":31207,"reactome":"R-HSA-77327.2","compounds":"FAD + H(+) + hexanoyl-CoA => (2E)-hexenoyl-CoA + FADH2"}
{"X":33146,"RHEA_ID":41179,"compounds":"1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-oxononanoate + H(+)"}
{"X":33147,"RHEA_ID":41180,"compounds":"1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-oxononanoate + H(+)"}
{"X":33148,"RHEA_ID":41181,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-oxononanoate + H(+) => 1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O"}
{"X":33149,"RHEA_ID":31212,"DIRECTION":"LR","MASTER_ID":31211,"reactome":"R-HSA-2408551.1","compounds":"ATP + H2O + L-selenomethionine => diphosphate + L-adenosylselenomethionine + phosphate"}
{"X":33150,"RHEA_ID":41183,"compounds":"1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-octadecyl-sn-glycero-3-phosphocholine + acetate + H(+)"}
{"X":33151,"RHEA_ID":41184,"compounds":"1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-O-octadecyl-sn-glycero-3-phosphocholine + acetate + H(+)"}
{"X":33152,"RHEA_ID":31215,"compounds":"(5-hydroxyindol-3-yl)acetaldehyde + H2O + NAD(+) = (5-hydroxyindol-3-yl)acetate + 2 H(+) + NADH"}
{"X":33153,"RHEA_ID":31216,"DIRECTION":"LR","MASTER_ID":31215,"metacyc":"RXN-10780","compounds":"(5-hydroxyindol-3-yl)acetaldehyde + H2O + NAD(+) => (5-hydroxyindol-3-yl)acetate + 2 H(+) + NADH"}
{"X":33154,"RHEA_ID":41187,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate"}
{"X":33155,"RHEA_ID":41188,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate"}
{"X":33156,"RHEA_ID":41189,"compounds":"2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + H2O"}
{"X":33157,"RHEA_ID":31220,"compounds":"5-hydroxykynurenamine + CO2 => 5-hydroxy-L-kynurenine + H(+)"}
{"X":33158,"RHEA_ID":41191,"compounds":"1-hexadecanoyl-2-propionyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + propanoate"}
{"X":33159,"RHEA_ID":41192,"compounds":"1-hexadecanoyl-2-propionyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + propanoate"}
{"X":33160,"RHEA_ID":41193,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + propanoate => 1-hexadecanoyl-2-propionyl-sn-glycero-3-phosphocholine + H2O"}
{"X":33161,"RHEA_ID":31224,"DIRECTION":"LR","MASTER_ID":31223,"metacyc":"RXN-8036","compounds":"cis-beta-D-glucosyl-2-hydroxycinnamate + H2O => beta-D-glucose + cis-2-coumarate"}
{"X":33162,"RHEA_ID":41195,"compounds":"1-hexadecanoyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + butanoate + H(+)"}
{"X":33163,"RHEA_ID":41196,"compounds":"1-hexadecanoyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + butanoate + H(+)"}
{"X":33164,"RHEA_ID":41197,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + butanoate + H(+) => 1-hexadecanoyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":33165,"RHEA_ID":31228,"compounds":"N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine-diphosphoundecaprenol + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine + UDP"}
{"X":33166,"RHEA_ID":31229,"compounds":"H(+) + N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine + UDP => N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine-diphosphoundecaprenol + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":33167,"RHEA_ID":51170,"compounds":"3,4-dihydroxymandelaldehyde + H2O2 + methylamine => (R)-adrenaline + H2O + O2"}
{"X":33168,"RHEA_ID":41201,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate => 1-hexadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":33169,"RHEA_ID":31232,"DIRECTION":"LR","MASTER_ID":31231,"metacyc":"RXN-37","compounds":"4-acetamidobutanal + H2O + NAD(+) => 4-acetamidobutanoate + 2 H(+) + NADH"}
{"X":33170,"RHEA_ID":31233,"compounds":"4-acetamidobutanoate + 2 H(+) + NADH => 4-acetamidobutanal + H2O + NAD(+)"}
{"X":33171,"RHEA_ID":51174,"compounds":"5-methylcytidine(62) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine => cytidine(62) in tRNA(Asp) + S-adenosyl-L-methionine"}
{"X":33172,"RHEA_ID":41205,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O"}
{"X":33173,"RHEA_ID":31236,"compounds":"2-oxoglutarate + erythro-4-hydroxy-L-glutamate => (4R)-4-hydroxy-2-oxoglutarate + L-glutamate"}
{"X":33174,"RHEA_ID":31237,"compounds":"(4R)-4-hydroxy-2-oxoglutarate + L-glutamate => 2-oxoglutarate + erythro-4-hydroxy-L-glutamate"}
{"X":33175,"RHEA_ID":41208,"compounds":"1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)"}
{"X":33176,"RHEA_ID":41209,"compounds":"2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + a fatty acid + H(+) => 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O"}
{"X":33177,"RHEA_ID":31240,"DIRECTION":"LR","MASTER_ID":31239,"reactome":"R-HSA-190182.1","compounds":"4 H(+) + uroporphyrinogen I => 4 CO2 + coproporphyrinogen I"}
{"X":33178,"RHEA_ID":31241,"compounds":"4 CO2 + coproporphyrinogen I => 4 H(+) + uroporphyrinogen I"}
{"X":33179,"RHEA_ID":51182,"compounds":"5-methylcytidine(49) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine => cytidine(49) in tRNA(Asp) + S-adenosyl-L-methionine"}
{"X":33180,"RHEA_ID":41213,"compounds":"2-hydroxy-(1H-indol-3-yl)acetate + H2O + NAD(+) => (indol-3-yl)acetate + H(+) + NADH + O2"}
{"X":33181,"RHEA_ID":31244,"DIRECTION":"LR","MASTER_ID":31243,"metacyc":"RXN-14472","compounds":"H2O + L-4-hydroxyglutamate semialdehyde + NAD(+) => erythro-4-hydroxy-L-glutamate + 2 H(+) + NADH"}
{"X":33182,"RHEA_ID":31245,"compounds":"erythro-4-hydroxy-L-glutamate + 2 H(+) + NADH => H2O + L-4-hydroxyglutamate semialdehyde + NAD(+)"}
{"X":33183,"RHEA_ID":51186,"compounds":"H(+) + octadecanoate + sn-glycero-3-phospho-L-serine => 1-octadecanoyl-sn-glycero-3-phosphoserine + H2O"}
{"X":33184,"RHEA_ID":31247,"compounds":"H(+) + prop-2-ynal + pyrroloquinoline quinol = prop-2-yn-1-ol + pyrroloquinoline quinone"}
{"X":33185,"RHEA_ID":31248,"compounds":"H(+) + prop-2-ynal + pyrroloquinoline quinol => prop-2-yn-1-ol + pyrroloquinoline quinone"}
{"X":33186,"RHEA_ID":31249,"compounds":"prop-2-yn-1-ol + pyrroloquinoline quinone => H(+) + prop-2-ynal + pyrroloquinoline quinol"}
{"X":33187,"RHEA_ID":41220,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O => (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+)"}
{"X":33188,"RHEA_ID":31251,"compounds":"(S)-3-hydroxyisobutanoyl-CoA + H2O = (S)-3-hydroxy-2-methylpropanoate + CoA + H(+)"}
{"X":33189,"RHEA_ID":31252,"compounds":"(S)-3-hydroxyisobutanoyl-CoA + H2O => (S)-3-hydroxy-2-methylpropanoate + CoA + H(+)"}
{"X":33190,"RHEA_ID":31253,"compounds":"(S)-3-hydroxy-2-methylpropanoate + CoA + H(+) => (S)-3-hydroxyisobutanoyl-CoA + H2O"}
{"X":33191,"RHEA_ID":41224,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":33192,"RHEA_ID":31255,"compounds":"(2S)-2-acetolactate = 3-hydroxy-3-methyl-2-oxobutanoate"}
{"X":33193,"RHEA_ID":41226,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":33194,"RHEA_ID":31257,"compounds":"3-hydroxy-3-methyl-2-oxobutanoate => (2S)-2-acetolactate"}
{"X":33195,"RHEA_ID":51195,"compounds":"(R)-2-hydroxyglutarate + NADP(+) <=> 2-oxoglutarate + H(+) + NADPH"}
{"X":33196,"RHEA_ID":31259,"compounds":"but-3-ynal + H2O + NAD(+) = 3-butynoate + 2 H(+) + NADH"}
{"X":33197,"RHEA_ID":51197,"compounds":"chloride(out) + Na(+)(out) + serotonin(out) => chloride(in) + Na(+)(in) + serotonin(in)"}
{"X":33198,"RHEA_ID":31261,"compounds":"3-butynoate + 2 H(+) + NADH => but-3-ynal + H2O + NAD(+)"}
{"X":33199,"RHEA_ID":41232,"compounds":"1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":33200,"RHEA_ID":31263,"compounds":"but-3-ynal + H(+) + pyrroloquinoline quinol = but-3-yn-1-ol + pyrroloquinoline quinone"}
{"X":33201,"RHEA_ID":41234,"compounds":"1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":33202,"RHEA_ID":31265,"compounds":"but-3-yn-1-ol + pyrroloquinoline quinone => but-3-ynal + H(+) + pyrroloquinoline quinol"}
{"X":33203,"RHEA_ID":51203,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-retinylidene-N-retinylethanolamine <=> H2O + N-retinylidene-N-retinylphosphatidylethanolamine"}
{"X":33204,"RHEA_ID":31267,"compounds":"6-hydroxyhexanoate + NADP(+) = 6-oxohexanoate + H(+) + NADPH"}
{"X":33205,"RHEA_ID":41242,"compounds":"N-acyl (9Z,12Z)-octadecadienoate octadecasphin-4E-enine + O2 <=> N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine"}
{"X":33206,"RHEA_ID":31269,"compounds":"6-oxohexanoate + H(+) + NADPH => 6-hydroxyhexanoate + NADP(+)"}
{"X":33207,"RHEA_ID":51207,"compounds":"6-trans-leukotriene B4 + NADP(+) <=> 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH"}
{"X":33208,"RHEA_ID":31271,"DIRECTION":"UN","MASTER_ID":31271,"ec":"1.14.13.135","compounds":"1-hydroxy-2-naphthoate + 2 H(+) + NADH + O2 = CO2 + H2O + NAD(+) + naphthalene-1,2-diol"}
{"X":33209,"RHEA_ID":41246,"compounds":"N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine <=> N-acyl-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecenoate (4E)-octadecasphin-4-enine"}
{"X":33210,"RHEA_ID":31273,"compounds":"CO2 + H2O + NAD(+) + naphthalene-1,2-diol => 1-hydroxy-2-naphthoate + 2 H(+) + NADH + O2"}
{"X":33211,"RHEA_ID":41248,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 9R-hydroperoxy(5Z,7E,11Z,14Z)-eicosatetraenoate"}
{"X":33212,"RHEA_ID":31275,"DIRECTION":"UN","MASTER_ID":31275,"ec":"1.1.1.31","compounds":"(S)-3-hydroxy-2-methylpropanoate + NAD(+) = (S)-methylmalonate semialdehyde + H(+) + NADH"}
{"X":33213,"RHEA_ID":41250,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 9R-hydroperoxy(5Z,7E,11Z,14Z)-eicosatetraenoate"}
{"X":33214,"RHEA_ID":31277,"compounds":"(S)-methylmalonate semialdehyde + H(+) + NADH => (S)-3-hydroxy-2-methylpropanoate + NAD(+)"}
{"X":33215,"RHEA_ID":41252,"compounds":"(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate => 7R-hydroxy-5S,6S-epoxy-(8Z,11Z,14Z)-eicosatrienoate"}
{"X":33216,"RHEA_ID":31279,"compounds":"(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = 2-cis,6-trans,10-trans-geranylgeranyl diphosphate + diphosphate"}
{"X":33217,"RHEA_ID":31280,"compounds":"(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate => 2-cis,6-trans,10-trans-geranylgeranyl diphosphate + diphosphate"}
{"X":33218,"RHEA_ID":31281,"compounds":"2-cis,6-trans,10-trans-geranylgeranyl diphosphate + diphosphate => (2E,6E)-farnesyl diphosphate + isopentenyl diphosphate"}
{"X":33219,"RHEA_ID":41256,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate"}
{"X":33220,"RHEA_ID":31283,"compounds":"FAD + H(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + FADH2"}
{"X":33221,"RHEA_ID":41258,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate"}
{"X":33222,"RHEA_ID":31285,"compounds":"dihydroxyacetone phosphate + FADH2 => FAD + H(+) + sn-glycerol 3-phosphate"}
{"X":33223,"RHEA_ID":51223,"DIRECTION":"BI","MASTER_ID":51220,"metacyc":"GST-RXN","compounds":"1-chloro-2,4-dinitrobenzene + glutathione <=> 2,4-dinitrophenyl-S-glutathione + chloride + H(+)"}
{"X":33224,"RHEA_ID":31287,"compounds":"H(+) + oxidized [electron-transfer flavoprotein] + propanoyl-CoA = acryloyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":33225,"RHEA_ID":31288,"DIRECTION":"LR","MASTER_ID":31287,"metacyc":"PROPCOASYN-RXN","compounds":"H(+) + oxidized [electron-transfer flavoprotein] + propanoyl-CoA => acryloyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":33226,"RHEA_ID":31289,"compounds":"acryloyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + propanoyl-CoA"}
{"X":33227,"RHEA_ID":51227,"compounds":"2 [Fe(III)cytochrome c] + S-sulfanyl-L-cysteinyl-[SoxY protein] + thiosulfate <=> 2 [Fe(II)cytochrome c] + 2 H(+) + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein]"}
{"X":33228,"RHEA_ID":31291,"compounds":"(S)-malate + FAD + H(+) = FADH2 + oxaloacetate"}
{"X":33229,"RHEA_ID":41266,"compounds":"NAD(+) + prostaglandin A1 <=> 15-keto-prostaglandin A1 + H(+) + NADH"}
{"X":33230,"RHEA_ID":31293,"compounds":"FADH2 + oxaloacetate => (S)-malate + FAD + H(+)"}
{"X":33231,"RHEA_ID":51231,"compounds":"17alpha-ethynylestradiol + 3'-phosphoadenylyl sulfate <=> 17alpha-ethynylestradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)"}
{"X":33232,"RHEA_ID":31295,"compounds":"(2E)-2-hydroxypenta-2,4-dienoate = 2-oxopent-4-enoate"}
{"X":33233,"RHEA_ID":41270,"compounds":"H2O + N-(15Z-tetracosenoyl)-sphing-4-enine <=> (15Z)-tetracosenoate + sphing-4-enine"}
{"X":33234,"RHEA_ID":31297,"compounds":"2-oxopent-4-enoate => (2E)-2-hydroxypenta-2,4-dienoate"}
{"X":33235,"RHEA_ID":41272,"compounds":"1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-O-hexadecyl-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":33236,"RHEA_ID":31299,"compounds":"H2O + NAD(+) + perillyl aldehyde = 2 H(+) + NADH + perillate"}
{"X":33237,"RHEA_ID":41274,"compounds":"1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-O-hexadecyl-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":33238,"RHEA_ID":31301,"compounds":"2 H(+) + NADH + perillate => H2O + NAD(+) + perillyl aldehyde"}
{"X":33239,"RHEA_ID":51239,"compounds":"GTP + L-glutamate + oxidized coenzyme F420-(gamma-Glu)(n) <=> GDP + H(+) + oxidized coenzyme F420-(gamma-Glu)(n+1) + phosphate"}
{"X":33240,"RHEA_ID":31303,"DIRECTION":"UN","MASTER_ID":31303,"ec":"1.5.1.36","compounds":"a reduced flavin + NAD(+) = an oxidized flavin + 2 H(+) + NADH"}
{"X":33241,"RHEA_ID":41278,"compounds":"H2O + N-eicosanoyl-sphing-4-enine <=> eicosanoate + sphing-4-enine"}
{"X":33242,"RHEA_ID":31305,"compounds":"an oxidized flavin + 2 H(+) + NADH => a reduced flavin + NAD(+)"}
{"X":33243,"RHEA_ID":31307,"DIRECTION":"UN","MASTER_ID":31307,"ec":"2.4.1.265","compounds":"alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate = alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+)"}
{"X":33244,"RHEA_ID":31308,"DIRECTION":"LR","MASTER_ID":31307,"metacyc":"RXN-5471","compounds":"alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate => alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+)"}
{"X":33245,"RHEA_ID":31309,"compounds":"alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate + H(+) => alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl beta-D-glucosyl phosphate"}
{"X":33246,"RHEA_ID":31311,"DIRECTION":"UN","MASTER_ID":31311,"ec":"2.4.1.266","compounds":"(2R)-3-phosphoglycerate + ADP-alpha-D-glucose = (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + ADP + H(+)"}
{"X":33247,"RHEA_ID":41286,"compounds":"H2O + N-(tetracosanoyl)-sphing-4-enine <=> sphing-4-enine + tetracosanoate"}
{"X":33248,"RHEA_ID":31313,"compounds":"(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + ADP + H(+) => (2R)-3-phosphoglycerate + ADP-alpha-D-glucose"}
{"X":33249,"RHEA_ID":41288,"compounds":"H2O + N-tetradecanoylsphing-4-enine => sphing-4-enine + tetradecanoate"}
{"X":33250,"RHEA_ID":31315,"DIRECTION":"UN","MASTER_ID":31315,"ec":"2.4.1.266","compounds":"(2R)-3-phosphoglycerate + GDP-D-glucose = (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP + H(+)"}
{"X":33251,"RHEA_ID":41290,"compounds":"H2O + N-tetradecanoylsphing-4-enine <=> sphing-4-enine + tetradecanoate"}
{"X":33252,"RHEA_ID":31317,"compounds":"(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP + H(+) => (2R)-3-phosphoglycerate + GDP-D-glucose"}
{"X":33253,"RHEA_ID":41292,"compounds":"H2O + N-dodecanoylsphing-4-enine => dodecanoate + sphing-4-enine"}
{"X":33254,"RHEA_ID":31319,"DIRECTION":"UN","MASTER_ID":31319,"ec":"2.4.1.266","compounds":"(2R)-3-phosphoglycerate + UDP-alpha-D-glucose = (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H(+) + UDP"}
{"X":33255,"RHEA_ID":41294,"compounds":"H2O + N-dodecanoylsphing-4-enine <=> dodecanoate + sphing-4-enine"}
{"X":33256,"RHEA_ID":31321,"compounds":"(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H(+) + UDP => (2R)-3-phosphoglycerate + UDP-alpha-D-glucose"}
{"X":33257,"RHEA_ID":41296,"compounds":"H2O + N-(hexanoyl)sphing-4-enine => hexanoate + sphing-4-enine"}
{"X":33258,"RHEA_ID":31323,"DIRECTION":"UN","MASTER_ID":31323,"ec":"2.4.1.270","compounds":"(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP-alpha-D-mannose = (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + GDP + H(+)"}
{"X":33259,"RHEA_ID":41298,"compounds":"H2O + N-(hexanoyl)sphing-4-enine <=> hexanoate + sphing-4-enine"}
{"X":33260,"RHEA_ID":31325,"compounds":"(2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + GDP + H(+) => (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP-alpha-D-mannose"}
{"X":33261,"RHEA_ID":61504,"DIRECTION":"UN","MASTER_ID":61504,"ec":"2.4.1.115","compounds":"pelargonidin + UDP-alpha-D-glucose = pelargonidin 3-O-beta-D-glucoside + UDP"}
{"X":33262,"RHEA_ID":31327,"DIRECTION":"UN","MASTER_ID":31327,"ec":"2.7.8.34","compounds":"1D-myo-inositol 3-phosphate + CDP-1L-myo-inositol = bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate + CMP + H(+)"}
{"X":33263,"RHEA_ID":41302,"compounds":"H2O + N-(9Z-octadecenoyl)-sphing-4-enine <=> (9Z)-octadecenoate + sphing-4-enine"}
{"X":33264,"RHEA_ID":31329,"compounds":"bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate + CMP + H(+) => 1D-myo-inositol 3-phosphate + CDP-1L-myo-inositol"}
{"X":33265,"RHEA_ID":61508,"DIRECTION":"UN","MASTER_ID":61508,"ec":"2.4.1.115","compounds":"peonidin + UDP-alpha-D-glucose = peonidin 3-O-beta-D-glucoside + UDP"}
{"X":33266,"RHEA_ID":31331,"DIRECTION":"UN","MASTER_ID":31331,"ec":"2.7.7.75","compounds":"ATP + H(+) + molybdopterin = adenylyl-molybdopterin + diphosphate"}
{"X":33267,"RHEA_ID":41306,"compounds":"H2O + N-(dodecanoyl)-4-hydroxysphinganine <=> 4-hydroxysphinganine + dodecanoate"}
{"X":33268,"RHEA_ID":31333,"compounds":"adenylyl-molybdopterin + diphosphate => ATP + H(+) + molybdopterin"}
{"X":33269,"RHEA_ID":41308,"compounds":"1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H2O => (9Z,12Z,15Z)-octadecatrienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":33270,"RHEA_ID":31335,"DIRECTION":"UN","MASTER_ID":31335,"ec":"2.7.7.76","compounds":"CTP + H(+) + Mo-molybdopterin = diphosphate + Mo-molybdopterin cytosine dinucleotide"}
{"X":33271,"RHEA_ID":41310,"compounds":"1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z,15Z)-octadecatrienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":33272,"RHEA_ID":31337,"compounds":"diphosphate + Mo-molybdopterin cytosine dinucleotide => CTP + H(+) + Mo-molybdopterin"}
{"X":33273,"RHEA_ID":41312,"compounds":"1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl (5Z,8Z,10E,12R,14Z)-hydroperoxyiecosatetraenoate"}
{"X":33274,"RHEA_ID":31339,"DIRECTION":"UN","MASTER_ID":31339,"ec":"6.2.1.35","compounds":"acetate + ATP + holo-[ACP] = acetyl-[ACP] + AMP + diphosphate"}
{"X":33275,"RHEA_ID":41314,"compounds":"1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl (5Z,8Z,10E,12R,14Z)-hydroperoxyiecosatetraenoate"}
{"X":33276,"RHEA_ID":31341,"compounds":"acetyl-[ACP] + AMP + diphosphate => acetate + ATP + holo-[ACP]"}
{"X":33277,"RHEA_ID":51279,"compounds":"(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate <=> (9S)-hydroperoxy-(10E,12Z)-octadecadienoate"}
{"X":33278,"RHEA_ID":31343,"DIRECTION":"UN","MASTER_ID":31343,"ec":"3.1.3.85","compounds":"(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H2O = (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate"}
{"X":33279,"RHEA_ID":31344,"DIRECTION":"LR","MASTER_ID":31343,"metacyc":"RXN-8852","compounds":"(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H2O => (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate"}
{"X":33280,"RHEA_ID":31345,"compounds":"(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate => (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H2O"}
{"X":33281,"RHEA_ID":41321,"compounds":"1-O-(9Z)-octadecenoyl-2-O-acetyl-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 2-acetyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":33282,"RHEA_ID":31347,"DIRECTION":"UN","MASTER_ID":31347,"ec":"3.2.1.175","compounds":"(+)-abscisic acid D-glucopyranosyl ester + H2O = 2-cis-(+)-abscisate + beta-D-glucose + H(+)"}
{"X":33283,"RHEA_ID":41323,"compounds":"1-O-(9Z)-octadecenoyl-2-O-acetyl-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 2-acetyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":33284,"RHEA_ID":31349,"compounds":"2-cis-(+)-abscisate + beta-D-glucose + H(+) => (+)-abscisic acid D-glucopyranosyl ester + H2O"}
{"X":33285,"RHEA_ID":41325,"compounds":"(5Z,8Z,11Z)-eicosatrienoate + O2 => (12S)-hydroperoxy-(5Z,8Z,10E)-eicosatrienoate"}
{"X":33286,"RHEA_ID":41326,"compounds":"(12S)-hydroperoxy-(5Z,8Z,10E)-eicosatrienoate => (5Z,8Z,11Z)-eicosatrienoate + O2"}
{"X":33287,"RHEA_ID":41327,"compounds":"(5Z,8Z,11Z)-eicosatrienoate + O2 <=> (12S)-hydroperoxy-(5Z,8Z,10E)-eicosatrienoate"}
{"X":33288,"RHEA_ID":31353,"DIRECTION":"RL","MASTER_ID":31351,"metacyc":"RXN-12338","compounds":"(S)-2,3-epoxysqualene + H2O => lupan-3beta,20-diol"}
{"X":33289,"RHEA_ID":41329,"compounds":"(8Z,11Z,14Z)-eicosatrienoate + O2 => (12S)-hydroperoxy-(8Z,10E,14Z)-eicosatrienoate"}
{"X":33290,"RHEA_ID":41330,"compounds":"(12S)-hydroperoxy-(8Z,10E,14Z)-eicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2"}
{"X":33291,"RHEA_ID":41331,"compounds":"(8Z,11Z,14Z)-eicosatrienoate + O2 <=> (12S)-hydroperoxy-(8Z,10E,14Z)-eicosatrienoate"}
{"X":33292,"RHEA_ID":31357,"compounds":"formaldehyde + H2O + methanethiol + NAD(+) => dimethyl sulfide + H(+) + NADH + O2"}
{"X":33293,"RHEA_ID":41334,"compounds":"(14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2"}
{"X":33294,"RHEA_ID":31360,"DIRECTION":"LR","MASTER_ID":31359,"metacyc":"RXN-9508","compounds":"FMNH2 + nitrilotriacetate + O2 => ammoniodiacetate + FMN + glyoxylate + H2O"}
{"X":33295,"RHEA_ID":31361,"compounds":"ammoniodiacetate + FMN + glyoxylate + H2O => FMNH2 + nitrilotriacetate + O2"}
{"X":33296,"RHEA_ID":51299,"compounds":"a quinone + H2O + L-methionyl-[protein] <=> a quinol + L-methionyl-(R)-S-oxide-[protein]"}
{"X":33297,"RHEA_ID":31363,"DIRECTION":"UN","MASTER_ID":31363,"ec":"1.6.99.n1","compounds":"NADP(+) + reduced coenzyme F420-(gamma-Glu)(n) = 2 H(+) + NADPH + oxidized coenzyme F420-(gamma-Glu)(n)"}
{"X":33298,"RHEA_ID":31363,"DIRECTION":"UN","MASTER_ID":31363,"ec":"1.5.1.40","compounds":"NADP(+) + reduced coenzyme F420-(gamma-Glu)(n) = 2 H(+) + NADPH + oxidized coenzyme F420-(gamma-Glu)(n)"}
{"X":33299,"RHEA_ID":31364,"compounds":"NADP(+) + reduced coenzyme F420-(gamma-Glu)(n) => 2 H(+) + NADPH + oxidized coenzyme F420-(gamma-Glu)(n)"}
{"X":33300,"RHEA_ID":41341,"compounds":"(6Z,9Z,12Z)-octadecatrienoate + O2 => 10R-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate"}
{"X":33301,"RHEA_ID":51304,"compounds":"(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate = (13R)-hydroperoxy-(9Z,11E)-octadecadienoate"}
{"X":33302,"RHEA_ID":31367,"DIRECTION":"UN","MASTER_ID":31367,"ec":"1.7.6.1","compounds":"2 H(+) + 3 nitrite = H2O + nitrate + 2 nitric oxide"}
{"X":33303,"RHEA_ID":31368,"compounds":"2 H(+) + 3 nitrite => H2O + nitrate + 2 nitric oxide"}
{"X":33304,"RHEA_ID":41345,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 => (5Z,7Z,8Z,10E,14Z,17Z)-12-hydroperoxyeicosapentaenoate"}
{"X":33305,"RHEA_ID":41346,"compounds":"(5Z,7Z,8Z,10E,14Z,17Z)-12-hydroperoxyeicosapentaenoate => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2"}
{"X":33306,"RHEA_ID":31371,"DIRECTION":"UN","MASTER_ID":31371,"ec":"2.1.1.212","compounds":"(2R,3S)-2,4',7-trihydroxyisoflavanone + S-adenosyl-L-methionine = (2R,3S)-2,7-dihydroxy-4'-methoxyisoflavanone + H(+) + S-adenosyl-L-homocysteine"}
{"X":33307,"RHEA_ID":31372,"DIRECTION":"LR","MASTER_ID":31371,"metacyc":"RXN-3624","compounds":"(2R,3S)-2,4',7-trihydroxyisoflavanone + S-adenosyl-L-methionine => (2R,3S)-2,7-dihydroxy-4'-methoxyisoflavanone + H(+) + S-adenosyl-L-homocysteine"}
{"X":33308,"RHEA_ID":41349,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate"}
{"X":33309,"RHEA_ID":51312,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine"}
{"X":33310,"RHEA_ID":31375,"DIRECTION":"UN","MASTER_ID":31375,"ec":"4.1.1.93","compounds":"H(+) + pyrrole-2-carboxylate = 1H-pyrrole + CO2"}
{"X":33311,"RHEA_ID":31376,"DIRECTION":"LR","MASTER_ID":31375,"metacyc":"RXN-12388","compounds":"H(+) + pyrrole-2-carboxylate => 1H-pyrrole + CO2"}
{"X":33312,"RHEA_ID":41353,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) => a 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine"}
{"X":33313,"RHEA_ID":41354,"compounds":"a 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol)"}
{"X":33314,"RHEA_ID":31379,"DIRECTION":"UN","MASTER_ID":31379,"ec":"4.1.1.93","compounds":"H2O + pyrrole-2-carboxylate = 1H-pyrrole + hydrogencarbonate"}
{"X":33315,"RHEA_ID":31380,"compounds":"H2O + pyrrole-2-carboxylate => 1H-pyrrole + hydrogencarbonate"}
{"X":33316,"RHEA_ID":41357,"compounds":"bacteriochlorophyll a + 3 NADP(+) => geranylgeranyl-bacteriochlorophyllide a + 3 H(+) + 3 NADPH"}
{"X":33317,"RHEA_ID":41358,"DIRECTION":"RL","MASTER_ID":41356,"metacyc":"RXN-17426","compounds":"geranylgeranyl-bacteriochlorophyllide a + 3 H(+) + 3 NADPH => bacteriochlorophyll a + 3 NADP(+)"}
{"X":33318,"RHEA_ID":31383,"DIRECTION":"UN","MASTER_ID":31383,"ec":"5.4.99.41","compounds":"(S)-2,3-epoxysqualene = lupeol"}
{"X":33319,"RHEA_ID":31384,"DIRECTION":"LR","MASTER_ID":31383,"metacyc":"RXN-111","compounds":"(S)-2,3-epoxysqualene => lupeol"}
{"X":33320,"RHEA_ID":31385,"compounds":"lupeol => (S)-2,3-epoxysqualene"}
{"X":33321,"RHEA_ID":51328,"compounds":"(8Z,11Z,14Z)-eicosatrienoate + O2 = 10-hydroperoxy-(8Z,11Z,14Z)-eicosatrienoate"}
{"X":33322,"RHEA_ID":31387,"DIRECTION":"UN","MASTER_ID":31387,"ec":"5.4.99.40","compounds":"(S)-2,3-epoxysqualene = alpha-amyrin"}
{"X":33323,"RHEA_ID":31388,"compounds":"(S)-2,3-epoxysqualene => alpha-amyrin"}
{"X":33324,"RHEA_ID":31389,"compounds":"alpha-amyrin => (S)-2,3-epoxysqualene"}
{"X":33325,"RHEA_ID":31390,"compounds":"(S)-2,3-epoxysqualene <=> alpha-amyrin"}
{"X":33326,"RHEA_ID":31391,"DIRECTION":"UN","MASTER_ID":31391,"ec":"1.3.8.2","compounds":"15-cis-4,4'-diapophytoene + 4 FAD + 4 H(+) = all-trans-4,4'-diapolycopene + 4 FADH2"}
{"X":33327,"RHEA_ID":31392,"compounds":"15-cis-4,4'-diapophytoene + 4 FAD + 4 H(+) => all-trans-4,4'-diapolycopene + 4 FADH2"}
{"X":33328,"RHEA_ID":41369,"compounds":"2-O-acetyl-1-O-tetradecyl-sn-glycero-3-phosphocholine + H2O => 1-O-tetradecyl-sn-glycero-3-phosphocholine + acetate + H(+)"}
{"X":33329,"RHEA_ID":41370,"compounds":"1-O-tetradecyl-sn-glycero-3-phosphocholine + acetate + H(+) => 2-O-acetyl-1-O-tetradecyl-sn-glycero-3-phosphocholine + H2O"}
{"X":33330,"RHEA_ID":31395,"compounds":"15-cis-4,4'-diapophytoene + FAD + H(+) = all-trans-4,4'-diapophytofluene + FADH2"}
{"X":33331,"RHEA_ID":31396,"DIRECTION":"LR","MASTER_ID":31395,"metacyc":"RXN-9303","compounds":"15-cis-4,4'-diapophytoene + FAD + H(+) => all-trans-4,4'-diapophytofluene + FADH2"}
{"X":33332,"RHEA_ID":41373,"compounds":"1-O-dodecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-O-dodecyl-sn-glycero-3-phosphocholine + acetate + H(+)"}
{"X":33333,"RHEA_ID":51340,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = 10-hydroperoxy-(4Z,7Z,11E,13Z,16Z,19Z)-docosahexaenoate"}
{"X":33334,"RHEA_ID":31399,"compounds":"all-trans-4,4'-diapophytofluene + FAD + H(+) = all-trans-4,4'-diapo-zeta-carotene + FADH2"}
{"X":33335,"RHEA_ID":31400,"DIRECTION":"LR","MASTER_ID":31399,"metacyc":"RXN-9304","compounds":"all-trans-4,4'-diapophytofluene + FAD + H(+) => all-trans-4,4'-diapo-zeta-carotene + FADH2"}
{"X":33336,"RHEA_ID":41377,"compounds":"1-O-decyl-2-O-acetyl-sn-glycero-3-phosphocholine + H2O => 1-O-decyl-sn-glycero-3-phosphocholine + acetate + H(+)"}
{"X":33337,"RHEA_ID":41378,"compounds":"1-O-decyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-O-decyl-2-O-acetyl-sn-glycero-3-phosphocholine + H2O"}
{"X":33338,"RHEA_ID":31403,"compounds":"all-trans-4,4'-diapo-zeta-carotene + FAD + H(+) = all-trans-4,4'-diaponeurosporene + FADH2"}
{"X":33339,"RHEA_ID":31404,"DIRECTION":"LR","MASTER_ID":31403,"metacyc":"RXN-9305","compounds":"all-trans-4,4'-diapo-zeta-carotene + FAD + H(+) => all-trans-4,4'-diaponeurosporene + FADH2"}
{"X":33340,"RHEA_ID":31405,"compounds":"all-trans-4,4'-diaponeurosporene + FADH2 => all-trans-4,4'-diapo-zeta-carotene + FAD + H(+)"}
{"X":33341,"RHEA_ID":51348,"compounds":"acetyl-CoA + 10 AH2 + 2 H(+) + 7 malonyl-CoA + 5 S-adenosyl-L-methionine = 10 A + 7 CO2 + 8 CoA + dehydroprobetaenone I + 6 H2O + 5 S-adenosyl-L-homocysteine"}
{"X":33342,"RHEA_ID":31407,"compounds":"all-trans-4,4'-diaponeurosporene + FAD + H(+) = all-trans-4,4'-diapolycopene + FADH2"}
{"X":33343,"RHEA_ID":31408,"DIRECTION":"LR","MASTER_ID":31407,"metacyc":"RXN-12258","compounds":"all-trans-4,4'-diaponeurosporene + FAD + H(+) => all-trans-4,4'-diapolycopene + FADH2"}
{"X":33344,"RHEA_ID":41385,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O => H(+) + hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":33345,"RHEA_ID":41386,"compounds":"H(+) + hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":33346,"RHEA_ID":31411,"DIRECTION":"UN","MASTER_ID":31411,"ec":"2.1.1.222","compounds":"a 3-(all-trans-polyprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = a 2-methoxy-6-(all-trans-polyprenyl)phenol + H(+) + S-adenosyl-L-homocysteine"}
{"X":33347,"RHEA_ID":31412,"compounds":"a 3-(all-trans-polyprenyl)benzene-1,2-diol + S-adenosyl-L-methionine => a 2-methoxy-6-(all-trans-polyprenyl)phenol + H(+) + S-adenosyl-L-homocysteine"}
{"X":33348,"RHEA_ID":31413,"compounds":"a 2-methoxy-6-(all-trans-polyprenyl)phenol + H(+) + S-adenosyl-L-homocysteine => a 3-(all-trans-polyprenyl)benzene-1,2-diol + S-adenosyl-L-methionine"}
{"X":33349,"RHEA_ID":51356,"compounds":"H2O + N-(9Z-octadecenoyl)-L-glutamine = (9Z)-octadecenoate + L-glutamine"}
{"X":33350,"RHEA_ID":31415,"compounds":"(2Z,6E)-farnesyl diphosphate = (+)-2-epi-prezizaene + diphosphate"}
{"X":33351,"RHEA_ID":31416,"compounds":"(2Z,6E)-farnesyl diphosphate => (+)-2-epi-prezizaene + diphosphate"}
{"X":33352,"RHEA_ID":41393,"compounds":"2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+)"}
{"X":33353,"RHEA_ID":41394,"compounds":"2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+) => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":33354,"RHEA_ID":31419,"compounds":"(2Z,6E)-farnesyl diphosphate = (-)-beta-curcumene + diphosphate"}
{"X":33355,"RHEA_ID":31420,"compounds":"(2Z,6E)-farnesyl diphosphate => (-)-beta-curcumene + diphosphate"}
{"X":33356,"RHEA_ID":41397,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine => 1-O-(1Z-alkenyl)-2-acetyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine"}
{"X":33357,"RHEA_ID":31422,"compounds":"(2Z,6E)-farnesyl diphosphate <=> (-)-beta-curcumene + diphosphate"}
{"X":33358,"RHEA_ID":41399,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine <=> 1-O-(1Z-alkenyl)-2-acetyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine"}
{"X":33359,"RHEA_ID":31424,"compounds":"(2Z,6E)-farnesyl diphosphate => (-)-alpha-cedrene + diphosphate"}
{"X":33360,"RHEA_ID":41401,"compounds":"1-hexanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexanoyl-sn-glycero-3-phosphate + choline + H(+)"}
{"X":33361,"RHEA_ID":31426,"compounds":"(2Z,6E)-farnesyl diphosphate <=> (-)-alpha-cedrene + diphosphate"}
{"X":33362,"RHEA_ID":41403,"compounds":"1-hexanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexanoyl-sn-glycero-3-phosphate + choline + H(+)"}
{"X":33363,"RHEA_ID":31428,"DIRECTION":"LR","MASTER_ID":31427,"metacyc":"RXN-8621","compounds":"(2E,6E)-farnesyl diphosphate => (-)-exo-alpha-bergamotene + diphosphate"}
{"X":33364,"RHEA_ID":41405,"compounds":"(R)-2-methylpyrrolidine + NADP(+) => 2-methyl-1-pyrroline + H(+) + NADPH"}
{"X":33365,"RHEA_ID":41406,"compounds":"2-methyl-1-pyrroline + H(+) + NADPH => (R)-2-methylpyrrolidine + NADP(+)"}
{"X":33366,"RHEA_ID":31431,"DIRECTION":"UN","MASTER_ID":31431,"ec":"4.2.3.83","compounds":"(2E,6E)-farnesyl diphosphate = (-)-beta-santalene + diphosphate"}
{"X":33367,"RHEA_ID":41408,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + N-(acetyl)-sphing-4-enine"}
{"X":33368,"RHEA_ID":31433,"compounds":"(-)-beta-santalene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":33369,"RHEA_ID":41410,"compounds":"1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + N-(acetyl)-sphing-4-enine => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine"}
{"X":33370,"RHEA_ID":31435,"DIRECTION":"UN","MASTER_ID":31435,"ec":"4.2.3.82","compounds":"(2E,6E)-farnesyl diphosphate = (+)-alpha-santalene + diphosphate"}
{"X":33371,"RHEA_ID":41412,"compounds":"1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-didecanoyl-sn-glycero-3-phosphate + choline + H(+)"}
{"X":33372,"RHEA_ID":41413,"compounds":"1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O => 1,2-didecanoyl-sn-glycero-3-phosphate + choline + H(+)"}
{"X":33373,"RHEA_ID":41414,"compounds":"1,2-didecanoyl-sn-glycero-3-phosphate + choline + H(+) => 1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":33374,"RHEA_ID":31439,"DIRECTION":"UN","MASTER_ID":31439,"ec":"4.2.3.80","compounds":"(2E,6E)-farnesyl diphosphate = alpha-longipinene + diphosphate"}
{"X":33375,"RHEA_ID":31440,"DIRECTION":"LR","MASTER_ID":31439,"metacyc":"RXN-8572","compounds":"(2E,6E)-farnesyl diphosphate => alpha-longipinene + diphosphate"}
{"X":33376,"RHEA_ID":41417,"compounds":"1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O => 1,2-dioctanoyl-sn-glycero-3-phosphate + choline + H(+)"}
{"X":33377,"RHEA_ID":41418,"compounds":"1,2-dioctanoyl-sn-glycero-3-phosphate + choline + H(+) => 1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":33378,"RHEA_ID":31443,"compounds":"ATP + D-sedoheptulose 7-phosphate = ADP + H(+) + sedoheptulose 1,7-bisphosphate"}
{"X":33379,"RHEA_ID":41420,"DIRECTION":"UN","MASTER_ID":41420,"ec":"1.10.3.15","compounds":"2 3-amino-4-hydroxybenzoate + H(+) + N-acetyl-L-cysteine + 2 O2 = CO2 + grixazone B + 4 H2O"}
{"X":33380,"RHEA_ID":41421,"compounds":"2 3-amino-4-hydroxybenzoate + H(+) + N-acetyl-L-cysteine + 2 O2 => CO2 + grixazone B + 4 H2O"}
{"X":33381,"RHEA_ID":41422,"compounds":"CO2 + grixazone B + 4 H2O => 2 3-amino-4-hydroxybenzoate + H(+) + N-acetyl-L-cysteine + 2 O2"}
{"X":33382,"RHEA_ID":31447,"compounds":"6-amino-2-oxohexanoate + H2O2 = 5-aminopentanoate + CO2 + H2O"}
{"X":33383,"RHEA_ID":31448,"DIRECTION":"LR","MASTER_ID":31447,"metacyc":"RXN-8243","compounds":"6-amino-2-oxohexanoate + H2O2 => 5-aminopentanoate + CO2 + H2O"}
{"X":33384,"RHEA_ID":41425,"compounds":"2 3-amino-4-hydroxybenzaldehyde + N-acetyl-L-cysteine + 2 O2 => formate + grixazone A + H(+) + 3 H2O"}
{"X":33385,"RHEA_ID":31450,"compounds":"6-amino-2-oxohexanoate + H2O2 <=> 5-aminopentanoate + CO2 + H2O"}
{"X":33386,"RHEA_ID":31451,"compounds":"2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + glycerol"}
{"X":33387,"RHEA_ID":31452,"DIRECTION":"LR","MASTER_ID":31451,"ecocyc":"CARDIOLIPSYN-RXN","metacyc":"CARDIOLIPSYN-RXN","compounds":"2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) => a cardiolipin + glycerol"}
{"X":33388,"RHEA_ID":41429,"DIRECTION":"LR","MASTER_ID":41428,"metacyc":"RXN-15305","compounds":"L-tyrosine + S-adenosyl-L-methionine => 3-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine"}
{"X":33389,"RHEA_ID":31455,"DIRECTION":"UN","MASTER_ID":31455,"ec":"1.5.1.41","compounds":"NAD(+) + reduced riboflavin = 2 H(+) + NADH + riboflavin"}
{"X":33390,"RHEA_ID":41432,"DIRECTION":"UN","MASTER_ID":41432,"ec":"1.11.2.5","compounds":"3-methyl-L-tyrosine + H2O2 = 5-hydroxy-3-methyl-L-tyrosine + H2O"}
{"X":33391,"RHEA_ID":41433,"compounds":"3-methyl-L-tyrosine + H2O2 => 5-hydroxy-3-methyl-L-tyrosine + H2O"}
{"X":33392,"RHEA_ID":41434,"compounds":"5-hydroxy-3-methyl-L-tyrosine + H2O => 3-methyl-L-tyrosine + H2O2"}
{"X":33393,"RHEA_ID":31459,"DIRECTION":"UN","MASTER_ID":31459,"ec":"5.3.99.10","compounds":"2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate = 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate"}
{"X":33394,"RHEA_ID":41436,"compounds":"(9Z)-octadecenoyl-CoA + cholesterol = cholesteryl (9Z-octadecenoate) + CoA"}
{"X":33395,"RHEA_ID":41437,"compounds":"(9Z)-octadecenoyl-CoA + cholesterol => cholesteryl (9Z-octadecenoate) + CoA"}
{"X":33396,"RHEA_ID":41438,"compounds":"cholesteryl (9Z-octadecenoate) + CoA => (9Z)-octadecenoyl-CoA + cholesterol"}
{"X":33397,"RHEA_ID":31463,"DIRECTION":"UN","MASTER_ID":31463,"ec":"2.4.1.271","compounds":"crocetin + UDP-alpha-D-glucose = beta-D-glucosyl crocetin + UDP"}
{"X":33398,"RHEA_ID":41440,"DIRECTION":"UN","MASTER_ID":41440,"ec":"1.14.11.46","compounds":"(2-aminoethyl)phosphonate + 2-oxoglutarate + O2 = (2R)-(2-amino-1-hydroxyethyl)phosphonate + CO2 + succinate"}
{"X":33399,"RHEA_ID":41441,"DIRECTION":"LR","MASTER_ID":41440,"metacyc":"RXN-15311","compounds":"(2-aminoethyl)phosphonate + 2-oxoglutarate + O2 => (2R)-(2-amino-1-hydroxyethyl)phosphonate + CO2 + succinate"}
{"X":33400,"RHEA_ID":41442,"compounds":"(2R)-(2-amino-1-hydroxyethyl)phosphonate + CO2 + succinate => (2-aminoethyl)phosphonate + 2-oxoglutarate + O2"}
{"X":33401,"RHEA_ID":31467,"DIRECTION":"UN","MASTER_ID":31467,"ec":"2.4.1.271","compounds":"beta-D-glucosyl crocetin + UDP-alpha-D-glucose = bis(beta-D-glucosyl) crocetin + UDP"}
{"X":33402,"RHEA_ID":41444,"DIRECTION":"UN","MASTER_ID":41444,"ec":"1.13.11.78","compounds":"(2R)-(2-amino-1-hydroxyethyl)phosphonate + O2 = glycine + 2 H(+) + phosphate"}
{"X":33403,"RHEA_ID":41445,"DIRECTION":"LR","MASTER_ID":41444,"metacyc":"RXN-15310","compounds":"(2R)-(2-amino-1-hydroxyethyl)phosphonate + O2 => glycine + 2 H(+) + phosphate"}
{"X":33404,"RHEA_ID":41446,"compounds":"glycine + 2 H(+) + phosphate => (2R)-(2-amino-1-hydroxyethyl)phosphonate + O2"}
{"X":33405,"RHEA_ID":31471,"DIRECTION":"UN","MASTER_ID":31471,"ec":"2.4.1.271","compounds":"beta-D-gentiobiosyl crocetin + UDP-alpha-D-glucose = beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP"}
{"X":33406,"RHEA_ID":31472,"DIRECTION":"LR","MASTER_ID":31471,"metacyc":"RXN-8475","compounds":"beta-D-gentiobiosyl crocetin + UDP-alpha-D-glucose => beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP"}
{"X":33407,"RHEA_ID":41449,"DIRECTION":"LR","MASTER_ID":41448,"metacyc":"RXN-13635","compounds":"2-oxoglutarate + L-isoleucine + O2 => (4S)-4-hydroxy-L-isoleucine + CO2 + succinate"}
{"X":33408,"RHEA_ID":41450,"compounds":"(4S)-4-hydroxy-L-isoleucine + CO2 + succinate => 2-oxoglutarate + L-isoleucine + O2"}
{"X":33409,"RHEA_ID":31475,"DIRECTION":"UN","MASTER_ID":31475,"ec":"2.4.1.262","compounds":"soyasapogenol B + UDP-alpha-D-glucuronate = H(+) + soyasapogenol B 3-O-beta-D-glucuronate + UDP"}
{"X":33410,"RHEA_ID":41452,"DIRECTION":"UN","MASTER_ID":41452,"ec":"1.14.13.189","compounds":"5-methyl-1-naphthoate + H(+) + NADPH + O2 = 3-hydroxy-5-methyl-1-naphthoate + H2O + NADP(+)"}
{"X":33411,"RHEA_ID":41453,"compounds":"5-methyl-1-naphthoate + H(+) + NADPH + O2 => 3-hydroxy-5-methyl-1-naphthoate + H2O + NADP(+)"}
{"X":33412,"RHEA_ID":41454,"compounds":"3-hydroxy-5-methyl-1-naphthoate + H2O + NADP(+) => 5-methyl-1-naphthoate + H(+) + NADPH + O2"}
{"X":33413,"RHEA_ID":31479,"DIRECTION":"UN","MASTER_ID":31479,"ec":"2.4.1.262","compounds":"soyasapogenol A + UDP-alpha-D-glucuronate = H(+) + soyasapogenol A 3-O-beta-D-glucuronate + UDP"}
{"X":33414,"RHEA_ID":41456,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + N-acylsphing-4-enine 1-phosphoethanolamine"}
{"X":33415,"RHEA_ID":31481,"compounds":"H(+) + soyasapogenol A 3-O-beta-D-glucuronate + UDP => soyasapogenol A + UDP-alpha-D-glucuronate"}
{"X":33416,"RHEA_ID":31482,"DIRECTION":"BI","MASTER_ID":31479,"metacyc":"RXN-14287","compounds":"soyasapogenol A + UDP-alpha-D-glucuronate <=> H(+) + soyasapogenol A 3-O-beta-D-glucuronate + UDP"}
{"X":33417,"RHEA_ID":31483,"DIRECTION":"UN","MASTER_ID":31483,"ec":"2.4.1.262","compounds":"soyasapogenol E + UDP-alpha-D-glucuronate = H(+) + soyasapogenol E 3-O-beta-D-glucuronate + UDP"}
{"X":33418,"RHEA_ID":41460,"compounds":"1,2-diacyl-glycero-3-phosphocholine + an N-acylsphing-4-enine = a 1,2-diacylglycerol + sphingomyelin"}
{"X":33419,"RHEA_ID":31485,"compounds":"H(+) + soyasapogenol E 3-O-beta-D-glucuronate + UDP => soyasapogenol E + UDP-alpha-D-glucuronate"}
{"X":33420,"RHEA_ID":31486,"DIRECTION":"BI","MASTER_ID":31483,"metacyc":"RXN-14287","compounds":"soyasapogenol E + UDP-alpha-D-glucuronate <=> H(+) + soyasapogenol E 3-O-beta-D-glucuronate + UDP"}
{"X":33421,"RHEA_ID":31487,"DIRECTION":"UN","MASTER_ID":31487,"ec":"2.4.1.272","compounds":"soyasapogenol B 3-O-beta-D-glucuronate + UDP-alpha-D-galactose = H(+) + soyasaponin III + UDP"}
{"X":33422,"RHEA_ID":41464,"DIRECTION":"UN","MASTER_ID":41464,"ec":"1.14.14.70","compounds":"ent-sandaracopimara-8(14),15-diene + O2 + reduced [NADPH--hemoprotein reductase] = ent-sandaracopimaradien-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":33423,"RHEA_ID":41465,"DIRECTION":"LR","MASTER_ID":41464,"metacyc":"RXN-15379","compounds":"ent-sandaracopimara-8(14),15-diene + O2 + reduced [NADPH--hemoprotein reductase] => ent-sandaracopimaradien-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":33424,"RHEA_ID":41466,"compounds":"ent-sandaracopimaradien-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-sandaracopimara-8(14),15-diene + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":33425,"RHEA_ID":31491,"DIRECTION":"UN","MASTER_ID":31491,"ec":"2.4.1.273","compounds":"soyasaponin III + UDP-beta-L-rhamnose = H(+) + soyasaponin I + UDP"}
{"X":33426,"RHEA_ID":31492,"DIRECTION":"LR","MASTER_ID":31491,"metacyc":"RXN-12320","compounds":"soyasaponin III + UDP-beta-L-rhamnose => H(+) + soyasaponin I + UDP"}
{"X":33427,"RHEA_ID":41469,"DIRECTION":"LR","MASTER_ID":41468,"metacyc":"RXN-15381","compounds":"ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oryzalexin E + oxidized [NADPH--hemoprotein reductase]"}
{"X":33428,"RHEA_ID":41470,"compounds":"H(+) + H2O + oryzalexin E + oxidized [NADPH--hemoprotein reductase] => ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":33429,"RHEA_ID":31495,"DIRECTION":"UN","MASTER_ID":31495,"ec":"2.4.1.274","compounds":"a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP"}
{"X":33430,"RHEA_ID":31496,"compounds":"a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP"}
{"X":33431,"RHEA_ID":31497,"compounds":"a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose"}
{"X":33432,"RHEA_ID":61773,"compounds":"rebaudioside E + UDP-alpha-D-glucose => H(+) + rebaudioside D + UDP"}
{"X":33433,"RHEA_ID":31499,"DIRECTION":"UN","MASTER_ID":31499,"ec":"2.4.1.275","compounds":"a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = a neolactoside nLc4Cer(d18:1(4E)) + H(+) + UDP"}
{"X":33434,"RHEA_ID":31500,"compounds":"a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose => a neolactoside nLc4Cer(d18:1(4E)) + H(+) + UDP"}
{"X":33435,"RHEA_ID":31501,"compounds":"a neolactoside nLc4Cer(d18:1(4E)) + H(+) + UDP => a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose"}
{"X":33436,"RHEA_ID":61777,"compounds":"rebaudioside D + UDP-alpha-D-glucose => H(+) + rebaudioside M + UDP"}
{"X":33437,"RHEA_ID":31503,"DIRECTION":"UN","MASTER_ID":31503,"ec":"2.5.1.95","compounds":"beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-diphospho-di-trans,octa-cis-undecaprenol + phosphoenolpyruvate = 4,6-Me(COOH)C-beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-diphospho-di-trans,octa-cis-undecaprenol + phosphate"}
{"X":33438,"RHEA_ID":31504,"DIRECTION":"LR","MASTER_ID":31503,"metacyc":"RXN-11802","compounds":"beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-diphospho-di-trans,octa-cis-undecaprenol + phosphoenolpyruvate => 4,6-Me(COOH)C-beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-diphospho-di-trans,octa-cis-undecaprenol + phosphate"}
{"X":33439,"RHEA_ID":41482,"compounds":"an episterol ester + CoA => an acyl-CoA + episterol"}
{"X":33440,"RHEA_ID":31507,"DIRECTION":"UN","MASTER_ID":31507,"ec":"4.3.3.6","compounds":"aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate"}
{"X":33441,"RHEA_ID":31508,"DIRECTION":"LR","MASTER_ID":31507,"metacyc":"RXN-11322","compounds":"aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine => H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate"}
{"X":33442,"RHEA_ID":51452,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + ursodeoxycholate = beta-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":33443,"RHEA_ID":41487,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine"}
{"X":33444,"RHEA_ID":31511,"DIRECTION":"UN","MASTER_ID":31511,"ec":"3.1.2.27","compounds":"chenodeoxycholoyl-CoA + H2O = chenodeoxycholate + CoA + H(+)"}
{"X":33445,"RHEA_ID":31512,"compounds":"chenodeoxycholoyl-CoA + H2O => chenodeoxycholate + CoA + H(+)"}
{"X":33446,"RHEA_ID":51456,"compounds":"H2O + N-(9Z-octadecenoyl)-L-isoleucine = (9Z)-octadecenoate + L-isoleucine"}
{"X":33447,"RHEA_ID":31515,"DIRECTION":"UN","MASTER_ID":31515,"ec":"1.2.1.82","compounds":"4'-apo-beta-carotenal + H2O + NAD(+) = 2 H(+) + NADH + neurosporaxanthin"}
{"X":33448,"RHEA_ID":31516,"DIRECTION":"LR","MASTER_ID":31515,"metacyc":"RXN-11998","compounds":"4'-apo-beta-carotenal + H2O + NAD(+) => 2 H(+) + NADH + neurosporaxanthin"}
{"X":33449,"RHEA_ID":51460,"compounds":"H2O + N-(9Z-octadecenoyl)-L-glutamate = (9Z)-octadecenoate + L-glutamate"}
{"X":33450,"RHEA_ID":41495,"compounds":"1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine"}
{"X":33451,"RHEA_ID":31519,"DIRECTION":"UN","MASTER_ID":31519,"ec":"1.13.11.59","compounds":"O2 + torulene = 3-methyl-2-butenal + 4'-apo-beta-carotenal"}
{"X":33452,"RHEA_ID":31520,"DIRECTION":"LR","MASTER_ID":31519,"metacyc":"RXN-11989","compounds":"O2 + torulene => 3-methyl-2-butenal + 4'-apo-beta-carotenal"}
{"X":33453,"RHEA_ID":51464,"compounds":"deoxycholate + O2 + reduced [NADPH--hemoprotein reductase] = 1beta-hydroxydeoxycholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":33454,"RHEA_ID":41499,"compounds":"1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine"}
{"X":33455,"RHEA_ID":31523,"DIRECTION":"UN","MASTER_ID":31523,"ec":"1.13.12.19","compounds":"2-oxoglutarate + 2 H(+) + O2 = 3 CO2 + ethene + H2O"}
{"X":33456,"RHEA_ID":31524,"DIRECTION":"LR","MASTER_ID":31523,"metacyc":"RXN-12538","compounds":"2-oxoglutarate + 2 H(+) + O2 => 3 CO2 + ethene + H2O"}
{"X":33457,"RHEA_ID":41502,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoserine + ethanolamine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + L-serine"}
{"X":33458,"RHEA_ID":31527,"compounds":"N(omega)-hydroxy-L-arginine = (S)-1-pyrroline-5-carboxylate + guanidine + H(+) + H2O"}
{"X":33459,"RHEA_ID":31528,"DIRECTION":"LR","MASTER_ID":31527,"metacyc":"RXN-12536","compounds":"N(omega)-hydroxy-L-arginine => (S)-1-pyrroline-5-carboxylate + guanidine + H(+) + H2O"}
{"X":33460,"RHEA_ID":41509,"DIRECTION":"LR","MASTER_ID":41508,"metacyc":"RXN-11128","compounds":"L-ornithine + NADPH + O2 => H2O + N(5)-hydroxy-L-ornithine + NADP(+)"}
{"X":33461,"RHEA_ID":41509,"DIRECTION":"LR","MASTER_ID":41508,"metacyc":"RXN-13783","compounds":"L-ornithine + NADPH + O2 => H2O + N(5)-hydroxy-L-ornithine + NADP(+)"}
{"X":33462,"RHEA_ID":31531,"compounds":"2-oxoglutarate + L-arginine + O2 = CO2 + N(omega)-hydroxy-L-arginine + succinate"}
{"X":33463,"RHEA_ID":31532,"DIRECTION":"LR","MASTER_ID":31531,"metacyc":"RXN-14542","compounds":"2-oxoglutarate + L-arginine + O2 => CO2 + N(omega)-hydroxy-L-arginine + succinate"}
{"X":33464,"RHEA_ID":41512,"DIRECTION":"UN","MASTER_ID":41512,"ec":"1.14.13.196","compounds":"L-ornithine + NADH + O2 = H2O + N(5)-hydroxy-L-ornithine + NAD(+)"}
{"X":33465,"RHEA_ID":41513,"DIRECTION":"LR","MASTER_ID":41512,"metacyc":"RXN-13783","compounds":"L-ornithine + NADH + O2 => H2O + N(5)-hydroxy-L-ornithine + NAD(+)"}
{"X":33466,"RHEA_ID":31535,"DIRECTION":"UN","MASTER_ID":31535,"ec":"1.14.20.7","compounds":"2-oxoglutarate + L-arginine + O2 = (S)-1-pyrroline-5-carboxylate + CO2 + guanidine + H(+) + H2O + succinate"}
{"X":33467,"RHEA_ID":31536,"DIRECTION":"LR","MASTER_ID":31535,"metacyc":"RXN-13396","compounds":"2-oxoglutarate + L-arginine + O2 => (S)-1-pyrroline-5-carboxylate + CO2 + guanidine + H(+) + H2O + succinate"}
{"X":33468,"RHEA_ID":41516,"DIRECTION":"UN","MASTER_ID":41516,"ec":"1.14.14.78","compounds":"O2 + phylloquinone + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + omega-hydroxyphylloquinone + oxidized [NADPH--hemoprotein reductase]"}
{"X":33469,"RHEA_ID":41517,"compounds":"O2 + phylloquinone + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + omega-hydroxyphylloquinone + oxidized [NADPH--hemoprotein reductase]"}
{"X":33470,"RHEA_ID":31539,"DIRECTION":"UN","MASTER_ID":31539,"ec":"2.1.1.232","compounds":"(S)-naringenin + S-adenosyl-L-methionine = (2S)-sakuranetin + H(+) + S-adenosyl-L-homocysteine"}
{"X":33471,"RHEA_ID":31540,"DIRECTION":"LR","MASTER_ID":31539,"metacyc":"RXN-7773","compounds":"(S)-naringenin + S-adenosyl-L-methionine => (2S)-sakuranetin + H(+) + S-adenosyl-L-homocysteine"}
{"X":33472,"RHEA_ID":41520,"DIRECTION":"UN","MASTER_ID":41520,"ec":"1.14.14.78","compounds":"menaquinone-4 + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + omega-hydroxymenaquinone-4 + oxidized [NADPH--hemoprotein reductase]"}
{"X":33473,"RHEA_ID":41521,"compounds":"menaquinone-4 + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + omega-hydroxymenaquinone-4 + oxidized [NADPH--hemoprotein reductase]"}
{"X":33474,"RHEA_ID":31543,"DIRECTION":"UN","MASTER_ID":31543,"ec":"2.4.1.276","compounds":"all-trans-zeaxanthin + 2 UDP-alpha-D-glucose = 2 H(+) + 2 UDP + zeaxanthin bis(beta-D-glucoside)"}
{"X":33475,"RHEA_ID":31544,"DIRECTION":"LR","MASTER_ID":31543,"metacyc":"RXN-12230","compounds":"all-trans-zeaxanthin + 2 UDP-alpha-D-glucose => 2 H(+) + 2 UDP + zeaxanthin bis(beta-D-glucoside)"}
{"X":33476,"RHEA_ID":51488,"compounds":"archaetidylserine + H(+) = archaetidylethanolamine + CO2"}
{"X":33477,"RHEA_ID":41525,"DIRECTION":"LR","MASTER_ID":41524,"metacyc":"RXN-9931","compounds":"5 H(+) + 5 malonyl-CoA => 5 CO2 + 5 CoA + H2O + naphthalene-1,3,6,8-tetrol"}
{"X":33478,"RHEA_ID":31547,"DIRECTION":"UN","MASTER_ID":31547,"ec":"2.5.1.96","compounds":"2 (2E,6E)-farnesyl diphosphate = 15-cis-4,4'-diapophytoene + 2 diphosphate"}
{"X":33479,"RHEA_ID":31548,"compounds":"2 (2E,6E)-farnesyl diphosphate => 15-cis-4,4'-diapophytoene + 2 diphosphate"}
{"X":33480,"RHEA_ID":41528,"compounds":"(2E)-octenoyl-[ACP] + H(+) + NADH = NAD(+) + octanoyl-[ACP]"}
{"X":33481,"RHEA_ID":41529,"compounds":"(2E)-octenoyl-[ACP] + H(+) + NADH => NAD(+) + octanoyl-[ACP]"}
{"X":33482,"RHEA_ID":31551,"compounds":"presqualene diphosphate = 15-cis-4,4'-diapophytoene + diphosphate"}
{"X":33483,"RHEA_ID":31552,"DIRECTION":"LR","MASTER_ID":31551,"metacyc":"RXN-9301","compounds":"presqualene diphosphate => 15-cis-4,4'-diapophytoene + diphosphate"}
{"X":33484,"RHEA_ID":41532,"DIRECTION":"UN","MASTER_ID":41532,"ec":"1.14.16.7","compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 3-hydroxy-L-phenylalanine"}
{"X":33485,"RHEA_ID":41533,"DIRECTION":"LR","MASTER_ID":41532,"metacyc":"RXN-13555","compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 => (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 3-hydroxy-L-phenylalanine"}
{"X":33486,"RHEA_ID":31555,"DIRECTION":"UN","MASTER_ID":31555,"ec":"2.3.1.247","compounds":"(5S)-5-amino-3-oxo-hexanoate + acetyl-CoA = (3S)-3-aminobutanoyl-CoA + acetoacetate"}
{"X":33487,"RHEA_ID":51499,"compounds":"a sphingoid base + ATP <=> a sphingoid 1-phosphate + ADP + H(+)"}
{"X":33488,"RHEA_ID":41536,"DIRECTION":"UN","MASTER_ID":41536,"ec":"2.1.1.303","compounds":"2,7-dihydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine = 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine"}
{"X":33489,"RHEA_ID":41537,"compounds":"2,7-dihydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine => 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine"}
{"X":33490,"RHEA_ID":31559,"DIRECTION":"UN","MASTER_ID":31559,"ec":"1.1.1.316","compounds":"L-galactose + NAD(+) = H(+) + L-galactono-1,4-lactone + NADH"}
{"X":33491,"RHEA_ID":41539,"DIRECTION":"BI","MASTER_ID":41536,"metacyc":"RXN-15306","compounds":"2,7-dihydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine <=> 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine"}
{"X":33492,"RHEA_ID":41540,"DIRECTION":"UN","MASTER_ID":41540,"ec":"2.1.1.305","compounds":"8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + S-adenosyl-L-methionine = 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine"}
{"X":33493,"RHEA_ID":41541,"DIRECTION":"LR","MASTER_ID":41540,"metacyc":"RXN-15405","compounds":"8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + S-adenosyl-L-methionine => 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine"}
{"X":33494,"RHEA_ID":31563,"DIRECTION":"UN","MASTER_ID":31563,"ec":"3.4.19.14","compounds":"H2O + leukotriene C4 = L-glutamate + leukotriene D4"}
{"X":33495,"RHEA_ID":41543,"compounds":"8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + S-adenosyl-L-methionine <=> 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine"}
{"X":33496,"RHEA_ID":41544,"DIRECTION":"UN","MASTER_ID":41544,"ec":"2.1.1.306","compounds":"8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine = 8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine"}
{"X":33497,"RHEA_ID":41545,"DIRECTION":"LR","MASTER_ID":41544,"metacyc":"RXN-15404","compounds":"8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine => 8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine"}
{"X":33498,"RHEA_ID":31567,"compounds":"bisphenol A + H(+) + NADH + O2 = 2,2-bis(4-hydroxyphenyl)-1-propanol + H2O + NAD(+)"}
{"X":33499,"RHEA_ID":41547,"compounds":"8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine <=> 8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine"}
{"X":33500,"RHEA_ID":41548,"DIRECTION":"UN","MASTER_ID":41548,"ec":"2.1.1.307","compounds":"8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine = 8-demethyl-8-(2,3,4-tri-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine"}
{"X":33501,"RHEA_ID":41549,"DIRECTION":"LR","MASTER_ID":41548,"metacyc":"RXN-15403","compounds":"8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine => 8-demethyl-8-(2,3,4-tri-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine"}
{"X":33502,"RHEA_ID":31571,"DIRECTION":"UN","MASTER_ID":31571,"ec":"1.14.13.135","compounds":"1-hydroxy-2-naphthoate + 2 H(+) + NADPH + O2 = CO2 + H2O + NADP(+) + naphthalene-1,2-diol"}
{"X":33503,"RHEA_ID":41551,"compounds":"8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine <=> 8-demethyl-8-(2,3,4-tri-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine"}
{"X":33504,"RHEA_ID":31573,"compounds":"CO2 + H2O + NADP(+) + naphthalene-1,2-diol => 1-hydroxy-2-naphthoate + 2 H(+) + NADPH + O2"}
{"X":33505,"RHEA_ID":41553,"compounds":"(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O => diphosphate + ophiobolin F"}
{"X":33506,"RHEA_ID":41554,"compounds":"diphosphate + ophiobolin F => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O"}
{"X":33507,"RHEA_ID":51519,"compounds":"(R)-reticuline + S-adenosyl-L-methionine <=> (R)-tembetarine + H(+) + S-adenosyl-L-homocysteine"}
{"X":33508,"RHEA_ID":31576,"DIRECTION":"LR","MASTER_ID":31575,"reactome":"R-HSA-2395849.3","compounds":"8-oxo-dGTP + H2O => 8-oxo-dGMP + diphosphate + H(+)"}
{"X":33509,"RHEA_ID":31577,"compounds":"8-oxo-dGMP + diphosphate + H(+) => 8-oxo-dGTP + H2O"}
{"X":33510,"RHEA_ID":41558,"compounds":"(3R)-3-hydroxy-L-arginyl-[ribosomal protein uL16] + CO2 + succinate => 2-oxoglutarate + L-arginyl-[ribosomal protein uL16] + O2"}
{"X":33511,"RHEA_ID":41559,"compounds":"2-oxoglutarate + L-arginyl-[ribosomal protein uL16] + O2 <=> (3R)-3-hydroxy-L-arginyl-[ribosomal protein uL16] + CO2 + succinate"}
{"X":33512,"RHEA_ID":31580,"compounds":"(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate => (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate"}
{"X":33513,"RHEA_ID":31581,"compounds":"(5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate => (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate"}
{"X":33514,"RHEA_ID":51526,"compounds":"magnoflorine + S-adenosyl-L-homocysteine => (S)-corytuberine + S-adenosyl-L-methionine"}
{"X":33515,"RHEA_ID":41563,"compounds":"(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FADH2 + O2 <=> (3S)-3-amino-3-(3-chloro-4,5-dihydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FAD + H(+) + H2O"}
{"X":33516,"RHEA_ID":31584,"DIRECTION":"LR","MASTER_ID":31583,"reactome":"R-HSA-2395818.3","compounds":"2-hydroxy-dATP + H2O => 2-hydroxy-dAMP + diphosphate + H(+)"}
{"X":33517,"RHEA_ID":31585,"compounds":"2-hydroxy-dAMP + diphosphate + H(+) => 2-hydroxy-dATP + H2O"}
{"X":33518,"RHEA_ID":31586,"compounds":"2-hydroxy-dATP + H2O <=> 2-hydroxy-dAMP + diphosphate + H(+)"}
{"X":33519,"RHEA_ID":31587,"DIRECTION":"UN","MASTER_ID":31587,"ec":"1.14.99.46","compounds":"FMNH2 + NADH + O2 + uracil = (Z)-3-ureidoacrylate + FMN + H(+) + H2O + NAD(+)"}
{"X":33520,"RHEA_ID":31588,"DIRECTION":"LR","MASTER_ID":31587,"ecocyc":"RXN0-6444","metacyc":"RXN0-6444","compounds":"FMNH2 + NADH + O2 + uracil => (Z)-3-ureidoacrylate + FMN + H(+) + H2O + NAD(+)"}
{"X":33521,"RHEA_ID":31589,"compounds":"(Z)-3-ureidoacrylate + FMN + H(+) + H2O + NAD(+) => FMNH2 + NADH + O2 + uracil"}
{"X":33522,"RHEA_ID":51534,"compounds":"5-hydroxyisourate + H2O + NADP(+) => H(+) + NADPH + O2 + urate"}
{"X":33523,"RHEA_ID":51535,"compounds":"H(+) + NADPH + O2 + urate <=> 5-hydroxyisourate + H2O + NADP(+)"}
{"X":33524,"RHEA_ID":31592,"DIRECTION":"LR","MASTER_ID":31591,"ecocyc":"RXN0-6460","metacyc":"RXN0-6460","compounds":"(Z)-3-ureidoacrylate peracid + H2O => (Z)-3-aminoperacrylic acid + carbamate + H(+)"}
{"X":33525,"RHEA_ID":31593,"compounds":"(Z)-3-aminoperacrylic acid + carbamate + H(+) => (Z)-3-ureidoacrylate peracid + H2O"}
{"X":33526,"RHEA_ID":41574,"compounds":"15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH => lipoxin A4 + NAD(+)"}
{"X":33527,"RHEA_ID":41575,"compounds":"lipoxin A4 + NAD(+) <=> 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH"}
{"X":33528,"RHEA_ID":31596,"DIRECTION":"LR","MASTER_ID":31595,"ecocyc":"RXN-12896","metacyc":"RXN-12896","compounds":"(Z)-2-methylureidoacrylate + H2O => (Z)-2-methylaminoacrylate + carbamate + H(+)"}
{"X":33529,"RHEA_ID":31597,"compounds":"(Z)-2-methylaminoacrylate + carbamate + H(+) => (Z)-2-methylureidoacrylate + H2O"}
{"X":33530,"RHEA_ID":41578,"compounds":"3-O-alpha-L-mycarosylerythronolide B + dTDP + H(+) => dTDP-beta-L-mycarose + erythronolide B"}
{"X":33531,"RHEA_ID":31599,"DIRECTION":"UN","MASTER_ID":31599,"ec":"1.14.99.46","compounds":"FMNH2 + NADH + O2 + thymine = (Z)-2-methylureidoacrylate + FMN + H(+) + H2O + NAD(+)"}
{"X":33532,"RHEA_ID":41580,"DIRECTION":"UN","MASTER_ID":41580,"ec":"2.5.1.121","compounds":"5,10-dihydrophenazine 1-carboxylate + dimethylallyl diphosphate = 5,10-dihydro-9-dimethylallylphenazine 1-carboxylate + diphosphate"}
{"X":33533,"RHEA_ID":31601,"compounds":"(Z)-2-methylureidoacrylate + FMN + H(+) + H2O + NAD(+) => FMNH2 + NADH + O2 + thymine"}
{"X":33534,"RHEA_ID":41582,"compounds":"5,10-dihydro-9-dimethylallylphenazine 1-carboxylate + diphosphate => 5,10-dihydrophenazine 1-carboxylate + dimethylallyl diphosphate"}
{"X":33535,"RHEA_ID":41583,"DIRECTION":"BI","MASTER_ID":41580,"metacyc":"RXN-15417","compounds":"5,10-dihydrophenazine 1-carboxylate + dimethylallyl diphosphate <=> 5,10-dihydro-9-dimethylallylphenazine 1-carboxylate + diphosphate"}
{"X":33536,"RHEA_ID":41584,"DIRECTION":"UN","MASTER_ID":41584,"ec":"2.5.1.122","compounds":"dimethylallyl diphosphate + L-tyrosine = 4-O-dimethylallyl-L-tyrosine + diphosphate"}
{"X":33537,"RHEA_ID":31605,"compounds":"(Z)-3-aminoacrylate + carbamate + H(+) => (Z)-3-ureidoacrylate + H2O"}
{"X":33538,"RHEA_ID":31606,"compounds":"(Z)-3-ureidoacrylate + H2O <=> (Z)-3-aminoacrylate + carbamate + H(+)"}
{"X":33539,"RHEA_ID":31607,"DIRECTION":"UN","MASTER_ID":31607,"ec":"4.2.1.131","compounds":"rhodopin = all-trans-lycopene + H2O"}
{"X":33540,"RHEA_ID":41588,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + choline + H(+)"}
{"X":33541,"RHEA_ID":31609,"DIRECTION":"RL","MASTER_ID":31607,"metacyc":"RXN-10643","compounds":"all-trans-lycopene + H2O => rhodopin"}
{"X":33542,"RHEA_ID":41590,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + choline + H(+) => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O"}
{"X":33543,"RHEA_ID":41591,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O <=> 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + choline + H(+)"}
{"X":33544,"RHEA_ID":41592,"compounds":"15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH = 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)"}
{"X":33545,"RHEA_ID":31613,"compounds":"H2O + rhodopin => 1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene"}
{"X":33546,"RHEA_ID":41594,"compounds":"15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+) => 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH"}
{"X":33547,"RHEA_ID":41595,"compounds":"15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH <=> 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)"}
{"X":33548,"RHEA_ID":41596,"compounds":"15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + H(+) + NADH = (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)"}
{"X":33549,"RHEA_ID":31617,"compounds":"dTDP-D-ravidosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine => dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose + 2 S-adenosyl-L-methionine"}
{"X":33550,"RHEA_ID":41598,"compounds":"(5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+) => 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + H(+) + NADH"}
{"X":33551,"RHEA_ID":41599,"compounds":"15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + H(+) + NADH <=> (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)"}
{"X":33552,"RHEA_ID":41600,"compounds":"1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine"}
{"X":33553,"RHEA_ID":31621,"compounds":"dTDP-3-dehydro-6-deoxy-alpha-D-galactose + L-glutamate => 2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose"}
{"X":33554,"RHEA_ID":41602,"compounds":"1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine => 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine"}
{"X":33555,"RHEA_ID":41603,"compounds":"1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine"}
{"X":33556,"RHEA_ID":41604,"compounds":"1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine"}
{"X":33557,"RHEA_ID":31625,"compounds":"H(+) + L-oleandrosyl-oleandolide + S-adenosyl-L-homocysteine => L-olivosyl-oleandolide + S-adenosyl-L-methionine"}
{"X":33558,"RHEA_ID":41606,"compounds":"1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine => 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + L-serine"}
{"X":33559,"RHEA_ID":31627,"DIRECTION":"UN","MASTER_ID":31627,"ec":"2.4.1.277","compounds":"10-deoxymethynolide + dTDP-alpha-D-desosamine = 10-deoxymethymycin + dTDP + H(+)"}
{"X":33560,"RHEA_ID":41608,"DIRECTION":"UN","MASTER_ID":41608,"ec":"2.8.2.37","compounds":"3'-phosphoadenylyl sulfate + alpha,alpha-trehalose = 2-O-sulfo-alpha,alpha-trehalose + adenosine 3',5'-bisphosphate + H(+)"}
{"X":33561,"RHEA_ID":31629,"compounds":"10-deoxymethymycin + dTDP + H(+) => 10-deoxymethynolide + dTDP-alpha-D-desosamine"}
{"X":33562,"RHEA_ID":41610,"compounds":"2-O-sulfo-alpha,alpha-trehalose + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + alpha,alpha-trehalose"}
{"X":33563,"RHEA_ID":61936,"compounds":"ATP + cycloheximide(in) + H2O = ADP + cycloheximide(out) + H(+) + phosphate"}
{"X":33564,"RHEA_ID":31632,"DIRECTION":"LR","MASTER_ID":31631,"metacyc":"RXN-10002","compounds":"2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H2O + phosphoenolpyruvate => phosphate + pseudaminate"}
{"X":33565,"RHEA_ID":41613,"DIRECTION":"LR","MASTER_ID":41612,"metacyc":"RXN-14995","compounds":"alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O => D-ribose 2,5-bisphosphate + H(+)"}
{"X":33566,"RHEA_ID":41614,"compounds":"D-ribose 2,5-bisphosphate + H(+) => alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O"}
{"X":33567,"RHEA_ID":41615,"compounds":"alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O <=> D-ribose 2,5-bisphosphate + H(+)"}
{"X":33568,"RHEA_ID":31636,"DIRECTION":"LR","MASTER_ID":31635,"metacyc":"RXN-12270","compounds":"beta-D-Delta(4)-GlcpA-(1->4)-beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-D-Glcp + H2O => 5-dehydro-4-deoxy-D-glucuronate + beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-D-Glcp"}
{"X":33569,"RHEA_ID":41617,"DIRECTION":"LR","MASTER_ID":41616,"metacyc":"RXN-14996","compounds":"D-ribose 2,5-bisphosphate + H2O => D-ribose 5-phosphate + phosphate"}
{"X":33570,"RHEA_ID":41618,"compounds":"D-ribose 5-phosphate + phosphate => D-ribose 2,5-bisphosphate + H2O"}
{"X":33571,"RHEA_ID":31639,"DIRECTION":"UN","MASTER_ID":31639,"ec":"2.1.1.237","compounds":"mycinamicin III + S-adenosyl-L-methionine = H(+) + mycinamicin IV + S-adenosyl-L-homocysteine"}
{"X":33572,"RHEA_ID":41624,"DIRECTION":"UN","MASTER_ID":41624,"ec":"3.13.1.4","compounds":"3-sulfinopropanoyl-CoA + H2O = H(+) + propanoyl-CoA + sulfite"}
{"X":33573,"RHEA_ID":31641,"compounds":"H(+) + mycinamicin IV + S-adenosyl-L-homocysteine => mycinamicin III + S-adenosyl-L-methionine"}
{"X":33574,"RHEA_ID":41626,"compounds":"H(+) + propanoyl-CoA + sulfite => 3-sulfinopropanoyl-CoA + H2O"}
{"X":33575,"RHEA_ID":31643,"DIRECTION":"UN","MASTER_ID":31643,"ec":"2.1.1.238","compounds":"mycinamicin VI + S-adenosyl-L-methionine = H(+) + mycinamicin III + S-adenosyl-L-homocysteine"}
{"X":33576,"RHEA_ID":31644,"DIRECTION":"LR","MASTER_ID":31643,"metacyc":"RXN-12801","compounds":"mycinamicin VI + S-adenosyl-L-methionine => H(+) + mycinamicin III + S-adenosyl-L-homocysteine"}
{"X":33577,"RHEA_ID":41629,"DIRECTION":"LR","MASTER_ID":41628,"metacyc":"RXN-15429","compounds":"geranylgeranyl diphosphate + H2O => cyclooctat-9-en-7-ol + diphosphate"}
{"X":33578,"RHEA_ID":41630,"compounds":"cyclooctat-9-en-7-ol + diphosphate => geranylgeranyl diphosphate + H2O"}
{"X":33579,"RHEA_ID":31647,"DIRECTION":"UN","MASTER_ID":31647,"ec":"3.2.1.180","compounds":"beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc6S + H2O = 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine 6-sulfate"}
{"X":33580,"RHEA_ID":41632,"compounds":"1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + L-serine = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phospho-L-serine + ethanolamine"}
{"X":33581,"RHEA_ID":41633,"compounds":"1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + L-serine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phospho-L-serine + ethanolamine"}
{"X":33582,"RHEA_ID":41634,"compounds":"1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phospho-L-serine + ethanolamine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + L-serine"}
{"X":33583,"RHEA_ID":31651,"DIRECTION":"UN","MASTER_ID":31651,"ec":"3.2.1.179","compounds":"beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc + H2O = 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine"}
{"X":33584,"RHEA_ID":41636,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + H2O = 1-O-(1Z-alkenyl)-sn-glycerol + phosphate"}
{"X":33585,"RHEA_ID":31653,"compounds":"5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine => beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc + H2O"}
{"X":33586,"RHEA_ID":31654,"compounds":"beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc + H2O <=> 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine"}
{"X":33587,"RHEA_ID":31655,"DIRECTION":"UN","MASTER_ID":31655,"ec":"3.2.1.179","compounds":"4-deoxy-Delta(4)-beta-D-GlcpA2S-(1->3)-beta-D-GalpNAc + H2O = 5-dehydro-4-deoxy-2-O-sulfo-D-glucuronate + N-acetyl-beta-D-galactosamine"}
{"X":33588,"RHEA_ID":31656,"compounds":"4-deoxy-Delta(4)-beta-D-GlcpA2S-(1->3)-beta-D-GalpNAc + H2O => 5-dehydro-4-deoxy-2-O-sulfo-D-glucuronate + N-acetyl-beta-D-galactosamine"}
{"X":33589,"RHEA_ID":41641,"DIRECTION":"LR","MASTER_ID":41640,"metacyc":"RXN-12746","compounds":"3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA => 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate"}
{"X":33590,"RHEA_ID":31658,"compounds":"4-deoxy-Delta(4)-beta-D-GlcpA2S-(1->3)-beta-D-GalpNAc + H2O <=> 5-dehydro-4-deoxy-2-O-sulfo-D-glucuronate + N-acetyl-beta-D-galactosamine"}
{"X":33591,"RHEA_ID":31659,"DIRECTION":"UN","MASTER_ID":31659,"ec":"3.2.1.179","compounds":"beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GlcpNAc + H2O = 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine"}
{"X":33592,"RHEA_ID":31660,"compounds":"beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GlcpNAc + H2O => 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine"}
{"X":33593,"RHEA_ID":41645,"DIRECTION":"LR","MASTER_ID":41644,"metacyc":"RXN-15307","compounds":"2-hydroxy-7-methoxy-5-methyl-1-naphthoate + ATP + CoA => 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA + AMP + diphosphate"}
{"X":33594,"RHEA_ID":31662,"compounds":"beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GlcpNAc + H2O <=> 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine"}
{"X":33595,"RHEA_ID":31663,"DIRECTION":"UN","MASTER_ID":31663,"ec":"2.6.1.34","compounds":"2-oxoglutarate + UDP-N-acetylbacillosamine = L-glutamate + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose"}
{"X":33596,"RHEA_ID":31664,"compounds":"2-oxoglutarate + UDP-N-acetylbacillosamine => L-glutamate + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose"}
{"X":33597,"RHEA_ID":31665,"DIRECTION":"RL","MASTER_ID":31663,"metacyc":"RXN-12812","compounds":"L-glutamate + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose => 2-oxoglutarate + UDP-N-acetylbacillosamine"}
{"X":33598,"RHEA_ID":41650,"compounds":"ADP + N(5)-phenyl-L-glutamine + phosphate => aniline + ATP + L-glutamate"}
{"X":33599,"RHEA_ID":31667,"DIRECTION":"UN","MASTER_ID":31667,"ec":"2.6.1.89","compounds":"2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-glucose = dTDP-3-dehydro-6-deoxy-alpha-D-glucose + L-glutamate"}
{"X":33600,"RHEA_ID":31668,"compounds":"2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-glucose => dTDP-3-dehydro-6-deoxy-alpha-D-glucose + L-glutamate"}
{"X":33601,"RHEA_ID":31669,"compounds":"dTDP-3-dehydro-6-deoxy-alpha-D-glucose + L-glutamate => 2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-glucose"}
{"X":33602,"RHEA_ID":41654,"compounds":"2-deoxy-alpha-L-fucosylaclacinomycin S + dTDP + H(+) => aclacinomycin S + dTDP-2-deoxy-beta-L-fucose"}
{"X":33603,"RHEA_ID":31671,"DIRECTION":"UN","MASTER_ID":31671,"ec":"2.1.1.235","compounds":"dTDP-3-amino-3,6-dideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine = dTDP-alpha-D-mycaminose + 2 H(+) + 2 S-adenosyl-L-homocysteine"}
{"X":33604,"RHEA_ID":31672,"DIRECTION":"LR","MASTER_ID":31671,"metacyc":"RXN-12772","compounds":"dTDP-3-amino-3,6-dideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine => dTDP-alpha-D-mycaminose + 2 H(+) + 2 S-adenosyl-L-homocysteine"}
{"X":33605,"RHEA_ID":31673,"compounds":"dTDP-alpha-D-mycaminose + 2 H(+) + 2 S-adenosyl-L-homocysteine => dTDP-3-amino-3,6-dideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine"}
{"X":33606,"RHEA_ID":51618,"compounds":"CO2 + dATP + H2O => ATP + formate + H(+)"}
{"X":33607,"RHEA_ID":61980,"compounds":"H(+) + NADPH + ubiquinone-10 = NADP(+) + ubiquinol-10"}
{"X":33608,"RHEA_ID":31676,"compounds":"NADP(+) + raucaffrinoline => H(+) + NADPH + perakine"}
{"X":33609,"RHEA_ID":31677,"DIRECTION":"RL","MASTER_ID":31675,"metacyc":"RXN-12673","compounds":"H(+) + NADPH + perakine => NADP(+) + raucaffrinoline"}
{"X":33610,"RHEA_ID":41662,"DIRECTION":"RL","MASTER_ID":41660,"metacyc":"RXN-9276","compounds":"NADH + sanguinarine => dihydrosanguinarine + NAD(+)"}
{"X":33611,"RHEA_ID":61984,"compounds":"H(+) + NADH + ubiquinone-10 = NAD(+) + ubiquinol-10"}
{"X":33612,"RHEA_ID":31680,"DIRECTION":"LR","MASTER_ID":31679,"metacyc":"RXN-12674","compounds":"O2 + prosolanapyrone II => H2O2 + prosolanapyrone III"}
{"X":33613,"RHEA_ID":31681,"compounds":"H2O2 + prosolanapyrone III => O2 + prosolanapyrone II"}
{"X":33614,"RHEA_ID":51626,"compounds":"CO2 + dGTP + H2O => formate + GTP + H(+)"}
{"X":33615,"RHEA_ID":31683,"DIRECTION":"UN","MASTER_ID":31683,"ec":"5.5.1.20","compounds":"prosolanapyrone III = (-)-solanapyrone A"}
{"X":33616,"RHEA_ID":31684,"compounds":"prosolanapyrone III => (-)-solanapyrone A"}
{"X":33617,"RHEA_ID":31685,"compounds":"(-)-solanapyrone A => prosolanapyrone III"}
{"X":33618,"RHEA_ID":51630,"compounds":"CO2 + dUTP + H2O => formate + H(+) + UTP"}
{"X":33619,"RHEA_ID":61992,"compounds":"N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine"}
{"X":33620,"RHEA_ID":31688,"DIRECTION":"LR","MASTER_ID":31687,"metacyc":"RXN-12759","compounds":"(9Z,12Z,15Z)-octadecatrienoate + O2 => (9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate"}
{"X":33621,"RHEA_ID":31689,"compounds":"(9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate => (9Z,12Z,15Z)-octadecatrienoate + O2"}
{"X":33622,"RHEA_ID":51634,"compounds":"all-trans-(4S,16)-dihydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-(4S)-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":33623,"RHEA_ID":41675,"compounds":"1-O-hexadecyl-sn-glycerol + ATP <=> 1-O-hexadecyl-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":33624,"RHEA_ID":31692,"compounds":"(9Z,12Z)-octadecadienoate + O2 => (9R,10E,12Z)-9-hydroperoxyoctadeca-10,12-dienoate"}
{"X":33625,"RHEA_ID":31693,"compounds":"(9R,10E,12Z)-9-hydroperoxyoctadeca-10,12-dienoate => (9Z,12Z)-octadecadienoate + O2"}
{"X":33626,"RHEA_ID":51638,"compounds":"a quinol + selenate => a quinone + H2O + selenite"}
{"X":33627,"RHEA_ID":41679,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycerol + ATP <=> 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":33628,"RHEA_ID":31696,"DIRECTION":"LR","MASTER_ID":31695,"metacyc":"RXN-12761","compounds":"(9Z,12Z)-octadecadienoate + O2 => (8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate"}
{"X":33629,"RHEA_ID":31697,"compounds":"(8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate => (9Z,12Z)-octadecadienoate + O2"}
{"X":33630,"RHEA_ID":51642,"compounds":"(11R)-hydroperoxy-(9Z,12Z)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2"}
{"X":33631,"RHEA_ID":31699,"DIRECTION":"UN","MASTER_ID":31699,"ec":"1.14.15.32","compounds":"4 H(+) + 2 O2 + pentalenene + 4 reduced [2Fe-2S]-[ferredoxin] = 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al"}
{"X":33632,"RHEA_ID":31700,"DIRECTION":"LR","MASTER_ID":31699,"metacyc":"RXN-13400","compounds":"4 H(+) + 2 O2 + pentalenene + 4 reduced [2Fe-2S]-[ferredoxin] => 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al"}
{"X":33633,"RHEA_ID":31701,"compounds":"3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al => 4 H(+) + 2 O2 + pentalenene + 4 reduced [2Fe-2S]-[ferredoxin]"}
{"X":33634,"RHEA_ID":51646,"compounds":"cholesta-5,7-dien-3beta-ol + 2 H2O + NAD(+) => cholesterol + H(+) + NADH + O2"}
{"X":33635,"RHEA_ID":31703,"compounds":"2 H(+) + O2 + pentalenene + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-ol"}
{"X":33636,"RHEA_ID":31704,"DIRECTION":"LR","MASTER_ID":31703,"metacyc":"RXN-12649","compounds":"2 H(+) + O2 + pentalenene + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-ol"}
{"X":33637,"RHEA_ID":41689,"compounds":"1-O-hexadecyl-2-propanoyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + propanoate"}
{"X":33638,"RHEA_ID":51650,"compounds":"[protein]-(S)-2-amino-6-oxohexanoate + acetamide + H2O2 => H2O + N(6)-acetyl-L-lysyl-[protein] + O2"}
{"X":33639,"RHEA_ID":31707,"compounds":"2 H(+) + O2 + pentalen-13-ol + 2 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al"}
{"X":33640,"RHEA_ID":31708,"DIRECTION":"LR","MASTER_ID":31707,"metacyc":"RXN-12650","compounds":"2 H(+) + O2 + pentalen-13-ol + 2 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al"}
{"X":33641,"RHEA_ID":41693,"compounds":"1-O-hexadecyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphocholine + butanoate + H(+)"}
{"X":33642,"RHEA_ID":51654,"compounds":"H(+) + keto-D-tagaturonate + NADH => D-mannonate + NAD(+)"}
{"X":33643,"RHEA_ID":31711,"DIRECTION":"UN","MASTER_ID":31711,"ec":"1.14.14.152","compounds":"beta-amyrin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 11-oxo-beta-amyrin + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":33644,"RHEA_ID":31712,"DIRECTION":"LR","MASTER_ID":31711,"metacyc":"RXN-12680","compounds":"beta-amyrin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 11-oxo-beta-amyrin + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":33645,"RHEA_ID":31713,"compounds":"11-oxo-beta-amyrin + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => beta-amyrin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}
{"X":33646,"RHEA_ID":51658,"compounds":"keto-D-fructuronate => keto-D-tagaturonate"}
{"X":33647,"RHEA_ID":31715,"compounds":"beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = 11alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":33648,"RHEA_ID":31716,"DIRECTION":"LR","MASTER_ID":31715,"metacyc":"RXN-12681","compounds":"beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => 11alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":33649,"RHEA_ID":41701,"compounds":"1-O-hexadecyl-2-glutaryl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphocholine + glutarate + H(+)"}
{"X":33650,"RHEA_ID":41702,"compounds":"1-O-hexadecyl-sn-glycero-3-phosphocholine + glutarate + H(+) => 1-O-hexadecyl-2-glutaryl-sn-glycero-3-phosphocholine + H2O"}
{"X":33651,"RHEA_ID":31719,"compounds":"11alpha-hydroxy-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = 11-oxo-beta-amyrin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":33652,"RHEA_ID":31720,"DIRECTION":"LR","MASTER_ID":31719,"metacyc":"RXN-12682","compounds":"11alpha-hydroxy-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => 11-oxo-beta-amyrin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":33653,"RHEA_ID":41705,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + H2O => 1-O-hexadecyl-sn-glycero-3-phosphate + acetate + H(+)"}
{"X":33654,"RHEA_ID":51666,"compounds":"H(+) + N-carbamoyl-D-phenylglycine => D-5-phenylhydantoin + H2O"}
{"X":33655,"RHEA_ID":31723,"DIRECTION":"UN","MASTER_ID":31723,"ec":"1.14.14.87","compounds":"liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase] = (2R,3S)-2,4',7-trihydroxyisoflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":33656,"RHEA_ID":31724,"DIRECTION":"LR","MASTER_ID":31723,"metacyc":"RXN-3283","compounds":"liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase] => (2R,3S)-2,4',7-trihydroxyisoflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":33657,"RHEA_ID":41709,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphoethanolamine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphoethanolamine + acetate + H(+)"}
{"X":33658,"RHEA_ID":41710,"compounds":"1-O-hexadecyl-sn-glycero-3-phosphoethanolamine + acetate + H(+) => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphoethanolamine + H2O"}
{"X":33659,"RHEA_ID":31727,"DIRECTION":"UN","MASTER_ID":31727,"ec":"1.14.14.11","compounds":"FADH2 + O2 + styrene = (2S)-2-phenyloxirane + FAD + H(+) + H2O"}
{"X":33660,"RHEA_ID":41712,"compounds":"a 2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)"}
{"X":33661,"RHEA_ID":31729,"compounds":"(2S)-2-phenyloxirane + FAD + H(+) + H2O => FADH2 + O2 + styrene"}
{"X":33662,"RHEA_ID":41714,"compounds":"a 2-acyl-sn-glycerol 3-phosphate + choline + H(+) => a 2-acyl-sn-glycero-3-phosphocholine + H2O"}
{"X":33663,"RHEA_ID":31731,"DIRECTION":"UN","MASTER_ID":31731,"ec":"1.14.14.12","compounds":"3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H(+) + H2O"}
{"X":33664,"RHEA_ID":31732,"DIRECTION":"LR","MASTER_ID":31731,"metacyc":"RXN-12717","compounds":"3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 => 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H(+) + H2O"}
{"X":33665,"RHEA_ID":51677,"compounds":"[protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide => [protein]-dithiol + 2 AH2 + H(+) + sulfite"}
{"X":33666,"RHEA_ID":41718,"compounds":"a 2-acyl-sn-glycerol 3-phosphate + H(+) + L-serine => a 2-acyl-sn-glycero-3-phospho-L-serine + H2O"}
{"X":33667,"RHEA_ID":31735,"DIRECTION":"UN","MASTER_ID":31735,"ec":"1.3.1.114","compounds":"3-oxocholan-24-oyl-CoA + NAD(+) = 3-oxochol-4-en-24-oyl-CoA + H(+) + NADH"}
{"X":33668,"RHEA_ID":31736,"compounds":"3-oxocholan-24-oyl-CoA + NAD(+) => 3-oxochol-4-en-24-oyl-CoA + H(+) + NADH"}
{"X":33669,"RHEA_ID":51681,"DIRECTION":"LR","MASTER_ID":51680,"metacyc":"RXN-11625","compounds":"(2E,6E)-farnesol + CTP => (2E,6E)-farnesyl phosphate + CDP + H(+)"}
{"X":33670,"RHEA_ID":31739,"DIRECTION":"UN","MASTER_ID":31739,"ec":"2.1.1.46","compounds":"a 4'-hydroxyisoflavone + S-adenosyl-L-methionine = a 4'-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine"}
{"X":33671,"RHEA_ID":31740,"DIRECTION":"LR","MASTER_ID":31739,"metacyc":"ISOFLAVONE-4-O-METHYLTRANSFERASE-RXN","compounds":"a 4'-hydroxyisoflavone + S-adenosyl-L-methionine => a 4'-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine"}
{"X":33672,"RHEA_ID":41725,"compounds":"dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] => (11R)-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":33673,"RHEA_ID":31742,"compounds":"a 4'-hydroxyisoflavone + S-adenosyl-L-methionine <=> a 4'-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine"}
{"X":33674,"RHEA_ID":31743,"DIRECTION":"UN","MASTER_ID":31743,"ec":"2.1.1.231","compounds":"a 4'-hydroxyflavanone + S-adenosyl-L-methionine = a 4'-methoxyflavanone + H(+) + S-adenosyl-L-homocysteine"}
{"X":33675,"RHEA_ID":31744,"DIRECTION":"LR","MASTER_ID":31743,"metacyc":"RXN-12719","compounds":"a 4'-hydroxyflavanone + S-adenosyl-L-methionine => a 4'-methoxyflavanone + H(+) + S-adenosyl-L-homocysteine"}
{"X":33676,"RHEA_ID":41729,"DIRECTION":"LR","MASTER_ID":41728,"metacyc":"RXN-16400","compounds":"(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":33677,"RHEA_ID":41730,"compounds":"18-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":33678,"RHEA_ID":31747,"DIRECTION":"UN","MASTER_ID":31747,"ec":"1.2.1.91","compounds":"3-oxo-5,6-dehydrosuberyl-CoA semialdehyde + H2O + NADP(+) = 3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH"}
{"X":33679,"RHEA_ID":31748,"DIRECTION":"LR","MASTER_ID":31747,"metacyc":"RXNMETA-12672","compounds":"3-oxo-5,6-dehydrosuberyl-CoA semialdehyde + H2O + NADP(+) => 3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH"}
{"X":33680,"RHEA_ID":41733,"compounds":"[(1->4)-alpha-D-glucosyl](n) + phosphate => [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate"}
{"X":33681,"RHEA_ID":41734,"compounds":"[(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate => [(1->4)-alpha-D-glucosyl](n) + phosphate"}
{"X":33682,"RHEA_ID":31751,"DIRECTION":"UN","MASTER_ID":31751,"ec":"1.17.7.2","compounds":"chlorophyllide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = 7(1)-hydroxychlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":33683,"RHEA_ID":31752,"compounds":"chlorophyllide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 7(1)-hydroxychlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":33684,"RHEA_ID":41736,"compounds":"3'-phosphoadenylyl sulfate + a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) = adenosine 3',5'-bisphosphate + beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+)"}
{"X":33685,"RHEA_ID":31754,"compounds":"chlorophyllide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 7(1)-hydroxychlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":33686,"RHEA_ID":31755,"DIRECTION":"UN","MASTER_ID":31755,"ec":"3.3.2.12","compounds":"2-oxepin-2(3H)-ylideneacetyl-CoA + H2O = 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde"}
{"X":33687,"RHEA_ID":31756,"DIRECTION":"LR","MASTER_ID":31755,"metacyc":"RXNMETA-12671","compounds":"2-oxepin-2(3H)-ylideneacetyl-CoA + H2O => 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde"}
{"X":33688,"RHEA_ID":41740,"DIRECTION":"UN","MASTER_ID":41740,"ec":"2.1.1.219","compounds":"adenosine(57)/adenosine(58) in tRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(1)-methyladenosine(57)/N(1)-methyladenosine(58) in tRNA + 2 S-adenosyl-L-homocysteine"}
{"X":33689,"RHEA_ID":41741,"DIRECTION":"LR","MASTER_ID":41740,"metacyc":"RXN-12469","compounds":"adenosine(57)/adenosine(58) in tRNA + 2 S-adenosyl-L-methionine => 2 H(+) + N(1)-methyladenosine(57)/N(1)-methyladenosine(58) in tRNA + 2 S-adenosyl-L-homocysteine"}
{"X":33690,"RHEA_ID":31759,"DIRECTION":"UN","MASTER_ID":31759,"ec":"2.1.1.234","compounds":"dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine = dTDP-alpha-D-desosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine"}
{"X":33691,"RHEA_ID":31760,"DIRECTION":"LR","MASTER_ID":31759,"metacyc":"RXN-12767","compounds":"dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine => dTDP-alpha-D-desosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine"}
{"X":33692,"RHEA_ID":31761,"compounds":"dTDP-alpha-D-desosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine => dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine"}
{"X":33693,"RHEA_ID":51706,"compounds":"4-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + xanthohumol"}
{"X":33694,"RHEA_ID":31763,"DIRECTION":"UN","MASTER_ID":31763,"ec":"2.6.1.88","compounds":"a 2-oxocarboxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + an L-alpha-amino acid"}
{"X":33695,"RHEA_ID":31764,"compounds":"a 2-oxocarboxylate + L-methionine => 4-methylsulfanyl-2-oxobutanoate + an L-alpha-amino acid"}
{"X":33696,"RHEA_ID":31765,"DIRECTION":"RL","MASTER_ID":31763,"reactome":"R-HSA-1237102.2","compounds":"4-methylsulfanyl-2-oxobutanoate + an L-alpha-amino acid => a 2-oxocarboxylate + L-methionine"}
{"X":33697,"RHEA_ID":41749,"compounds":"3'-phosphoadenylyl sulfate + a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol => 3-O-sulfo-beta-D-galactosyl-diacylglycerol + adenosine 3',5'-bisphosphate + H(+)"}
{"X":33698,"RHEA_ID":31767,"DIRECTION":"UN","MASTER_ID":31767,"ec":"2.6.1.92","compounds":"2-oxoglutarate + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine = L-glutamate + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose"}
{"X":33699,"RHEA_ID":31768,"compounds":"2-oxoglutarate + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine => L-glutamate + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose"}
{"X":33700,"RHEA_ID":31769,"compounds":"L-glutamate + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose => 2-oxoglutarate + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine"}
{"X":33701,"RHEA_ID":51714,"compounds":"keto-D-fructose 6-phosphate => keto-D-tagatose 6-phosphate"}
{"X":33702,"RHEA_ID":31771,"DIRECTION":"UN","MASTER_ID":31771,"ec":"3.1.1.64","compounds":"an all-trans-retinyl ester + H2O = 11-cis-retinol + a fatty acid + H(+)"}
{"X":33703,"RHEA_ID":31772,"DIRECTION":"LR","MASTER_ID":31771,"metacyc":"RXN-12550","compounds":"an all-trans-retinyl ester + H2O => 11-cis-retinol + a fatty acid + H(+)"}
{"X":33704,"RHEA_ID":31773,"compounds":"11-cis-retinol + a fatty acid + H(+) => an all-trans-retinyl ester + H2O"}
{"X":33705,"RHEA_ID":51718,"compounds":"AMP(in) + diphosphate(in) + H(+)(in) + hexadecanoyl-CoA(in) => ATP(in) + CoA(in) + H(+)(out) + hexadecanoate(out)"}
{"X":33706,"RHEA_ID":31775,"DIRECTION":"UN","MASTER_ID":31775,"ec":"3.1.1.64","compounds":"all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + H(+) + hexadecanoate"}
{"X":33707,"RHEA_ID":31776,"compounds":"all-trans-retinyl hexadecanoate + H2O => 11-cis-retinol + H(+) + hexadecanoate"}
{"X":33708,"RHEA_ID":31777,"compounds":"11-cis-retinol + H(+) + hexadecanoate => all-trans-retinyl hexadecanoate + H2O"}
{"X":33709,"RHEA_ID":51722,"compounds":"AMP(in) + diphosphate(in) + H(+)(in) + octadecanoyl-CoA(in) => ATP(in) + CoA(in) + H(+)(out) + octadecanoate(out)"}
{"X":33710,"RHEA_ID":31779,"DIRECTION":"UN","MASTER_ID":31779,"ec":"3.1.1.90","compounds":"an all-trans-retinyl ester + H2O = 13-cis-retinol + a fatty acid + H(+)"}
{"X":33711,"RHEA_ID":31780,"DIRECTION":"LR","MASTER_ID":31779,"metacyc":"RXN-12576","compounds":"an all-trans-retinyl ester + H2O => 13-cis-retinol + a fatty acid + H(+)"}
{"X":33712,"RHEA_ID":31781,"compounds":"13-cis-retinol + a fatty acid + H(+) => an all-trans-retinyl ester + H2O"}
{"X":33713,"RHEA_ID":41765,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GD3 (d18:1(4E)) => CMP + ganglioside GT3 (d18:1(4E)) + H(+)"}
{"X":33714,"RHEA_ID":31783,"DIRECTION":"UN","MASTER_ID":31783,"ec":"3.1.7.8","compounds":"H2O + tuberculosinyl diphosphate = diphosphate + tuberculosinol"}
{"X":33715,"RHEA_ID":31784,"DIRECTION":"LR","MASTER_ID":31783,"metacyc":"RXN-9459","compounds":"H2O + tuberculosinyl diphosphate => diphosphate + tuberculosinol"}
{"X":33716,"RHEA_ID":31785,"compounds":"diphosphate + tuberculosinol => H2O + tuberculosinyl diphosphate"}
{"X":33717,"RHEA_ID":51730,"compounds":"dihydroxyacetone + phosphate => dihydroxyacetone phosphate + H2O"}
{"X":33718,"RHEA_ID":41770,"compounds":"CMP + ganglioside GT1a (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GD1a (18:1(4E))"}
{"X":33719,"RHEA_ID":31788,"compounds":"H2O + tuberculosinyl diphosphate => (13R)-edaxadiene + diphosphate"}
{"X":33720,"RHEA_ID":31789,"compounds":"(13R)-edaxadiene + diphosphate => H2O + tuberculosinyl diphosphate"}
{"X":33721,"RHEA_ID":41773,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GT1b (d18:1(4E)) => CMP + ganglioside GQ1b (d18:1(4E)) + H(+)"}
{"X":33722,"RHEA_ID":41774,"compounds":"CMP + ganglioside GQ1b (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GT1b (d18:1(4E))"}
{"X":33723,"RHEA_ID":31792,"DIRECTION":"LR","MASTER_ID":31791,"metacyc":"RXN-12814","compounds":"H2O + tuberculosinyl diphosphate => (13S)-edaxadiene + diphosphate"}
{"X":33724,"RHEA_ID":31793,"compounds":"(13S)-edaxadiene + diphosphate => H2O + tuberculosinyl diphosphate"}
{"X":33725,"RHEA_ID":51738,"compounds":"H(+) + N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => L-lysyl-[protein] + S-adenosyl-L-methionine"}
{"X":33726,"RHEA_ID":41778,"compounds":"CMP + ganglioside GM2 (d18:1(4E)/18:0) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E)/18:0)"}
{"X":33727,"RHEA_ID":31796,"compounds":"(+)-beta-caryophyllene + H2O => (+)-caryolan-1-ol"}
{"X":33728,"RHEA_ID":31797,"compounds":"(+)-caryolan-1-ol => (+)-beta-caryophyllene + H2O"}
{"X":33729,"RHEA_ID":41781,"compounds":"a D-galactosylceramide + CMP-N-acetyl-beta-neuraminate => CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-D-galactosylceramide"}
{"X":33730,"RHEA_ID":41782,"compounds":"CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-D-galactosylceramide => a D-galactosylceramide + CMP-N-acetyl-beta-neuraminate"}
{"X":33731,"RHEA_ID":31800,"DIRECTION":"LR","MASTER_ID":31799,"metacyc":"RXN-12613","compounds":"4-amino-5-aminomethyl-2-methylpyrimidine + H2O => 4-amino-5-hydroxymethyl-2-methylpyrimidine + NH4(+)"}
{"X":33732,"RHEA_ID":31801,"compounds":"4-amino-5-hydroxymethyl-2-methylpyrimidine + NH4(+) => 4-amino-5-aminomethyl-2-methylpyrimidine + H2O"}
{"X":33733,"RHEA_ID":41785,"compounds":"asialo-GM1a ganglioside (d18:1(4E)/18:0) + CMP-N-acetyl-beta-neuraminate => CMP + ganglioside GM1 (d18:1(4E)/18:0) + H(+)"}
{"X":33734,"RHEA_ID":51747,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A <=> a 1,2-diacyl-sn-glycerol + lipid A 1-(2-aminoethyl diphosphate)"}
{"X":33735,"RHEA_ID":31804,"DIRECTION":"LR","MASTER_ID":31803,"metacyc":"RXN-10001","compounds":"H2O + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose => 2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H(+) + UDP"}
{"X":33736,"RHEA_ID":31805,"compounds":"2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H(+) + UDP => H2O + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose"}
{"X":33737,"RHEA_ID":41789,"compounds":"acetyl-CoA + holo-[ACP] => acetyl-[ACP] + CoA"}
{"X":33738,"RHEA_ID":41790,"compounds":"acetyl-[ACP] + CoA => acetyl-CoA + holo-[ACP]"}
{"X":33739,"RHEA_ID":31808,"DIRECTION":"LR","MASTER_ID":31807,"metacyc":"RXN-8556","compounds":"(2E,6E)-farnesyl diphosphate => alpha-guaiene + diphosphate"}
{"X":33740,"RHEA_ID":31809,"compounds":"alpha-guaiene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":33741,"RHEA_ID":41793,"compounds":"holo-[ACP] + malonyl-CoA => CoA + malonyl-[ACP]"}
{"X":33742,"RHEA_ID":41794,"compounds":"CoA + malonyl-[ACP] => holo-[ACP] + malonyl-CoA"}
{"X":33743,"RHEA_ID":31812,"DIRECTION":"LR","MASTER_ID":31811,"metacyc":"RXN-12823","compounds":"(2E,6E)-farnesyl diphosphate => diphosphate + viridiflorene"}
{"X":33744,"RHEA_ID":41796,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoylsphinganine = a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphocholine"}
{"X":33745,"RHEA_ID":41797,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoylsphinganine => a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphocholine"}
{"X":33746,"RHEA_ID":41798,"compounds":"a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoylsphinganine"}
{"X":33747,"RHEA_ID":31816,"DIRECTION":"LR","MASTER_ID":31815,"metacyc":"RXN-12774","compounds":"(2E,6E)-farnesyl diphosphate => (+)-beta-caryophyllene + diphosphate"}
{"X":33748,"RHEA_ID":41800,"compounds":"acetyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + holo-[ACP]"}
{"X":33749,"RHEA_ID":41801,"compounds":"acetyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxobutanoyl-[ACP] + CO2 + holo-[ACP]"}
{"X":33750,"RHEA_ID":41802,"compounds":"3-oxobutanoyl-[ACP] + CO2 + holo-[ACP] => acetyl-[ACP] + H(+) + malonyl-[ACP]"}
{"X":33751,"RHEA_ID":31820,"DIRECTION":"LR","MASTER_ID":31819,"metacyc":"RXN-12824","compounds":"(2E,6E)-farnesyl diphosphate => 5-epi-alpha-selinene + diphosphate"}
{"X":33752,"RHEA_ID":41804,"compounds":"3-oxobutanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxybutanoyl-[ACP] + NADP(+)"}
{"X":33753,"RHEA_ID":41805,"compounds":"3-oxobutanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxybutanoyl-[ACP] + NADP(+)"}
{"X":33754,"RHEA_ID":31823,"DIRECTION":"UN","MASTER_ID":31823,"ec":"4.2.3.91","compounds":"(2E,6E)-farnesyl diphosphate + H2O = cubebol + diphosphate"}
{"X":33755,"RHEA_ID":41807,"compounds":"3-oxobutanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxybutanoyl-[ACP] + NADP(+)"}
{"X":33756,"RHEA_ID":31825,"compounds":"cubebol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}
{"X":33757,"RHEA_ID":41809,"compounds":"(3R)-hydroxybutanoyl-[ACP] => (2E)-butenoyl-[ACP] + H2O"}
{"X":33758,"RHEA_ID":31827,"DIRECTION":"UN","MASTER_ID":31827,"ec":"4.2.3.92","compounds":"(2E,6E)-farnesyl diphosphate = (+)-gamma-cadinene + diphosphate"}
{"X":33759,"RHEA_ID":41811,"compounds":"(3R)-hydroxybutanoyl-[ACP] <=> (2E)-butenoyl-[ACP] + H2O"}
{"X":33760,"RHEA_ID":41812,"compounds":"(2E)-butenoyl-[ACP] + H(+) + NADPH = butanoyl-[ACP] + NADP(+)"}
{"X":33761,"RHEA_ID":41813,"compounds":"(2E)-butenoyl-[ACP] + H(+) + NADPH => butanoyl-[ACP] + NADP(+)"}
{"X":33762,"RHEA_ID":31831,"DIRECTION":"UN","MASTER_ID":31831,"ec":"4.2.3.93","compounds":"(2E,6E)-farnesyl diphosphate = delta-guaiene + diphosphate"}
{"X":33763,"RHEA_ID":31832,"DIRECTION":"LR","MASTER_ID":31831,"metacyc":"RXN-12822","compounds":"(2E,6E)-farnesyl diphosphate => delta-guaiene + diphosphate"}
{"X":33764,"RHEA_ID":31833,"compounds":"delta-guaiene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":33765,"RHEA_ID":51778,"compounds":"deoxycohumulone + diphosphate => 4-prenylphlorisobutanophenone + dimethylallyl diphosphate"}
{"X":33766,"RHEA_ID":31835,"DIRECTION":"UN","MASTER_ID":31835,"ec":"5.3.2.3","compounds":"dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-3-dehydro-6-deoxy-alpha-D-galactose"}
{"X":33767,"RHEA_ID":41819,"compounds":"ganglioside GD3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> ganglioside GD2 (d18:1(4E)) + H(+) + UDP"}
{"X":33768,"RHEA_ID":31837,"compounds":"dTDP-3-dehydro-6-deoxy-alpha-D-galactose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose"}
{"X":33769,"RHEA_ID":51782,"compounds":"deoxyadlupulone + diphosphate => 4-prenylphlormethylbutanophenone + dimethylallyl diphosphate"}
{"X":33770,"RHEA_ID":31839,"DIRECTION":"UN","MASTER_ID":31839,"ec":"5.3.2.4","compounds":"dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-3-dehydro-6-deoxy-alpha-D-glucose"}
{"X":33771,"RHEA_ID":41823,"compounds":"butanoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxohexanoyl-[ACP] + CO2 + holo-[ACP]"}
{"X":33772,"RHEA_ID":31841,"compounds":"dTDP-3-dehydro-6-deoxy-alpha-D-glucose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose"}
{"X":33773,"RHEA_ID":51786,"compounds":"deoxyhumulone + diphosphate => 4-prenylphlorisovalerophenone + dimethylallyl diphosphate"}
{"X":33774,"RHEA_ID":31843,"DIRECTION":"UN","MASTER_ID":31843,"ec":"5.3.3.18","compounds":"2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA = 2-oxepin-2(3H)-ylideneacetyl-CoA"}
{"X":33775,"RHEA_ID":41827,"compounds":"3-oxohexanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxyhexanoyl-[ACP] + NADP(+)"}
{"X":33776,"RHEA_ID":31845,"compounds":"2-oxepin-2(3H)-ylideneacetyl-CoA => 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA"}
{"X":33777,"RHEA_ID":31846,"DIRECTION":"BI","MASTER_ID":31843,"ecocyc":"RXN0-6510","metacyc":"RXN0-6510","compounds":"2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA <=> 2-oxepin-2(3H)-ylideneacetyl-CoA"}
{"X":33778,"RHEA_ID":41830,"compounds":"(2E)-hexenoyl-[ACP] + H2O => (3R)-hydroxyhexanoyl-[ACP]"}
{"X":33779,"RHEA_ID":41831,"compounds":"(3R)-hydroxyhexanoyl-[ACP] <=> (2E)-hexenoyl-[ACP] + H2O"}
{"X":33780,"RHEA_ID":31849,"compounds":"shionone => (S)-2,3-epoxysqualene"}
{"X":33781,"RHEA_ID":41833,"compounds":"(2E)-hexenoyl-[ACP] + H(+) + NADPH => hexanoyl-[ACP] + NADP(+)"}
{"X":33782,"RHEA_ID":41834,"compounds":"hexanoyl-[ACP] + NADP(+) => (2E)-hexenoyl-[ACP] + H(+) + NADPH"}
{"X":33783,"RHEA_ID":31852,"compounds":"(S)-2,3-epoxysqualene => parkeol"}
{"X":33784,"RHEA_ID":31853,"compounds":"parkeol => (S)-2,3-epoxysqualene"}
{"X":33785,"RHEA_ID":41837,"compounds":"H(+) + hexanoyl-[ACP] + malonyl-[ACP] => 3-oxooctanoyl-[ACP] + CO2 + holo-[ACP]"}
{"X":33786,"RHEA_ID":41838,"compounds":"3-oxooctanoyl-[ACP] + CO2 + holo-[ACP] => H(+) + hexanoyl-[ACP] + malonyl-[ACP]"}
{"X":33787,"RHEA_ID":41839,"compounds":"H(+) + hexanoyl-[ACP] + malonyl-[ACP] <=> 3-oxooctanoyl-[ACP] + CO2 + holo-[ACP]"}
{"X":33788,"RHEA_ID":31857,"compounds":"achilleol B => (S)-2,3-epoxysqualene"}
{"X":33789,"RHEA_ID":41841,"compounds":"3-oxooctanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxyoctanoyl-[ACP] + NADP(+)"}
{"X":33790,"RHEA_ID":41842,"compounds":"(3R)-hydroxyoctanoyl-[ACP] + NADP(+) => 3-oxooctanoyl-[ACP] + H(+) + NADPH"}
{"X":33791,"RHEA_ID":41843,"compounds":"3-oxooctanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxyoctanoyl-[ACP] + NADP(+)"}
{"X":33792,"RHEA_ID":31861,"compounds":"glutinol => (S)-2,3-epoxysqualene"}
{"X":33793,"RHEA_ID":41845,"compounds":"(3R)-hydroxyoctanoyl-[ACP] => (2E)-octenoyl-[ACP] + H2O"}
{"X":33794,"RHEA_ID":31863,"DIRECTION":"UN","MASTER_ID":31863,"ec":"5.4.99.50","compounds":"(S)-2,3-epoxysqualene = friedelin"}
{"X":33795,"RHEA_ID":41847,"compounds":"(3R)-hydroxyoctanoyl-[ACP] <=> (2E)-octenoyl-[ACP] + H2O"}
{"X":33796,"RHEA_ID":31865,"compounds":"friedelin => (S)-2,3-epoxysqualene"}
{"X":33797,"RHEA_ID":41849,"compounds":"(2E)-octenoyl-[ACP] + H(+) + NADPH => NADP(+) + octanoyl-[ACP]"}
{"X":33798,"RHEA_ID":41850,"compounds":"NADP(+) + octanoyl-[ACP] => (2E)-octenoyl-[ACP] + H(+) + NADPH"}
{"X":33799,"RHEA_ID":31868,"compounds":"(S)-2,3-epoxysqualene => baccharis oxide"}
{"X":33800,"RHEA_ID":31869,"compounds":"baccharis oxide => (S)-2,3-epoxysqualene"}
{"X":33801,"RHEA_ID":41853,"compounds":"H(+) + malonyl-[ACP] + octanoyl-[ACP] => 3-oxodecanoyl-[ACP] + CO2 + holo-[ACP]"}
{"X":33802,"RHEA_ID":41854,"compounds":"3-oxodecanoyl-[ACP] + CO2 + holo-[ACP] => H(+) + malonyl-[ACP] + octanoyl-[ACP]"}
{"X":33803,"RHEA_ID":31872,"compounds":"(S)-2,3-epoxysqualene => alpha-seco-amyrin"}
{"X":33804,"RHEA_ID":31873,"compounds":"alpha-seco-amyrin => (S)-2,3-epoxysqualene"}
{"X":33805,"RHEA_ID":41857,"compounds":"3-oxodecanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxydecanoyl-[ACP] + NADP(+)"}
{"X":33806,"RHEA_ID":41858,"compounds":"(3R)-hydroxydecanoyl-[ACP] + NADP(+) => 3-oxodecanoyl-[ACP] + H(+) + NADPH"}
{"X":33807,"RHEA_ID":41859,"compounds":"3-oxodecanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxydecanoyl-[ACP] + NADP(+)"}
{"X":33808,"RHEA_ID":31877,"compounds":"marneral => (S)-2,3-epoxysqualene"}
{"X":33809,"RHEA_ID":41861,"DIRECTION":"LR","MASTER_ID":41860,"ecocyc":"RXN-9655","metacyc":"RXN-9655","compounds":"(3R)-hydroxydecanoyl-[ACP] => (2E)-decenoyl-[ACP] + H2O"}
{"X":33810,"RHEA_ID":41862,"compounds":"(2E)-decenoyl-[ACP] + H2O => (3R)-hydroxydecanoyl-[ACP]"}
{"X":33811,"RHEA_ID":31880,"compounds":"(S)-2,3-epoxysqualene => beta-seco-amyrin"}
{"X":33812,"RHEA_ID":31881,"compounds":"beta-seco-amyrin => (S)-2,3-epoxysqualene"}
{"X":33813,"RHEA_ID":41865,"compounds":"(2E)-decenoyl-[ACP] + H(+) + NADPH => decanoyl-[ACP] + NADP(+)"}
{"X":33814,"RHEA_ID":41866,"compounds":"decanoyl-[ACP] + NADP(+) => (2E)-decenoyl-[ACP] + H(+) + NADPH"}
{"X":33815,"RHEA_ID":41867,"compounds":"(2E)-decenoyl-[ACP] + H(+) + NADPH <=> decanoyl-[ACP] + NADP(+)"}
{"X":33816,"RHEA_ID":31885,"compounds":"delta-amyrin => (S)-2,3-epoxysqualene"}
{"X":33817,"RHEA_ID":41869,"compounds":"decanoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxododecanoyl-[ACP] + CO2 + holo-[ACP]"}
{"X":33818,"RHEA_ID":31887,"DIRECTION":"UN","MASTER_ID":31887,"ec":"5.4.99.56","compounds":"(S)-2,3-epoxysqualene = tirucalladienol"}
{"X":33819,"RHEA_ID":41871,"compounds":"decanoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxododecanoyl-[ACP] + CO2 + holo-[ACP]"}
{"X":33820,"RHEA_ID":31889,"compounds":"tirucalladienol => (S)-2,3-epoxysqualene"}
{"X":33821,"RHEA_ID":31890,"compounds":"(S)-2,3-epoxysqualene <=> tirucalladienol"}
{"X":33822,"RHEA_ID":41874,"compounds":"(3R)-hydroxydodecanoyl-[ACP] + NADP(+) => 3-oxododecanoyl-[ACP] + H(+) + NADPH"}
{"X":33823,"RHEA_ID":41875,"compounds":"3-oxododecanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxydodecanoyl-[ACP] + NADP(+)"}
{"X":33824,"RHEA_ID":31893,"compounds":"1-phenyl-1,2-propanedione + H(+) + NADPH => 2-hydroxy-1-phenyl-1-propanone + NADP(+)"}
{"X":33825,"RHEA_ID":31894,"compounds":"2-hydroxy-1-phenyl-1-propanone + NADP(+) <=> 1-phenyl-1,2-propanedione + H(+) + NADPH"}
{"X":33826,"RHEA_ID":41878,"compounds":"(2E)-dodecenoyl-[ACP] + H2O => (3R)-hydroxydodecanoyl-[ACP]"}
{"X":33827,"RHEA_ID":41879,"compounds":"(3R)-hydroxydodecanoyl-[ACP] <=> (2E)-dodecenoyl-[ACP] + H2O"}
{"X":33828,"RHEA_ID":31897,"compounds":"(1E,4E,8E)-alpha-humulene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":33829,"RHEA_ID":41881,"compounds":"(2E)-dodecenoyl-[ACP] + H(+) + NADPH => dodecanoyl-[ACP] + NADP(+)"}
{"X":33830,"RHEA_ID":41882,"compounds":"dodecanoyl-[ACP] + NADP(+) => (2E)-dodecenoyl-[ACP] + H(+) + NADPH"}
{"X":33831,"RHEA_ID":41883,"compounds":"(2E)-dodecenoyl-[ACP] + H(+) + NADPH <=> dodecanoyl-[ACP] + NADP(+)"}
{"X":33832,"RHEA_ID":31901,"compounds":"H(+) + H2O + indolin-2-one + oxidized [NADPH--hemoprotein reductase] => indole + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":33833,"RHEA_ID":41885,"compounds":"dodecanoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxotetradecanoyl-[ACP] + CO2 + holo-[ACP]"}
{"X":33834,"RHEA_ID":41886,"compounds":"3-oxotetradecanoyl-[ACP] + CO2 + holo-[ACP] => dodecanoyl-[ACP] + H(+) + malonyl-[ACP]"}
{"X":33835,"RHEA_ID":41887,"compounds":"dodecanoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxotetradecanoyl-[ACP] + CO2 + holo-[ACP]"}
{"X":33836,"RHEA_ID":31909,"compounds":"(S)-coclaurine + H(+) + S-adenosyl-L-homocysteine => (S)-norcoclaurine + S-adenosyl-L-methionine"}
{"X":33837,"RHEA_ID":41889,"compounds":"3-oxotetradecanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxytetradecanoyl-[ACP] + NADP(+)"}
{"X":33838,"RHEA_ID":31911,"DIRECTION":"UN","MASTER_ID":31911,"ec":"2.2.1.11","compounds":"beta-D-fructose 1,6-bisphosphate + methylglyoxal = 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde 3-phosphate"}
{"X":33839,"RHEA_ID":41891,"compounds":"3-oxotetradecanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxytetradecanoyl-[ACP] + NADP(+)"}
{"X":33840,"RHEA_ID":31913,"compounds":"1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde 3-phosphate => beta-D-fructose 1,6-bisphosphate + methylglyoxal"}
{"X":33841,"RHEA_ID":41893,"compounds":"(3R)-hydroxytetradecanoyl-[ACP] => (2E)-tetradecenoyl-[ACP] + H2O"}
{"X":33842,"RHEA_ID":41894,"compounds":"(2E)-tetradecenoyl-[ACP] + H2O => (3R)-hydroxytetradecanoyl-[ACP]"}
{"X":33843,"RHEA_ID":41895,"compounds":"(3R)-hydroxytetradecanoyl-[ACP] <=> (2E)-tetradecenoyl-[ACP] + H2O"}
{"X":33844,"RHEA_ID":31917,"compounds":"ADP + alpha-maltose 1-phosphate + H(+) => ATP + D-maltose"}
{"X":33845,"RHEA_ID":41897,"compounds":"(2E)-tetradecenoyl-[ACP] + H(+) + NADPH => NADP(+) + tetradecanoyl-[ACP]"}
{"X":33846,"RHEA_ID":41898,"compounds":"NADP(+) + tetradecanoyl-[ACP] => (2E)-tetradecenoyl-[ACP] + H(+) + NADPH"}
{"X":33847,"RHEA_ID":41899,"compounds":"(2E)-tetradecenoyl-[ACP] + H(+) + NADPH <=> NADP(+) + tetradecanoyl-[ACP]"}
{"X":33848,"RHEA_ID":31921,"compounds":"3-hydroxyindolin-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => indolin-2-one + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":33849,"RHEA_ID":41901,"compounds":"H(+) + malonyl-[ACP] + tetradecanoyl-[ACP] => 3-oxohexadecanoyl-[ACP] + CO2 + holo-[ACP]"}
{"X":33850,"RHEA_ID":41902,"compounds":"3-oxohexadecanoyl-[ACP] + CO2 + holo-[ACP] => H(+) + malonyl-[ACP] + tetradecanoyl-[ACP]"}
{"X":33851,"RHEA_ID":41903,"compounds":"H(+) + malonyl-[ACP] + tetradecanoyl-[ACP] <=> 3-oxohexadecanoyl-[ACP] + CO2 + holo-[ACP]"}
{"X":33852,"RHEA_ID":31929,"compounds":"2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-hydroxyindolin-2-one + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":33853,"RHEA_ID":41905,"compounds":"3-oxohexadecanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxyhexadecanoyl-[ACP] + NADP(+)"}
{"X":33854,"RHEA_ID":41906,"compounds":"(3R)-hydroxyhexadecanoyl-[ACP] + NADP(+) => 3-oxohexadecanoyl-[ACP] + H(+) + NADPH"}
{"X":33855,"RHEA_ID":31940,"DIRECTION":"LR","MASTER_ID":31939,"metacyc":"RXN-6684","compounds":"2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + O2 + reduced [NADPH--hemoprotein reductase] => DIBOA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":33856,"RHEA_ID":31941,"compounds":"DIBOA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":33857,"RHEA_ID":41909,"compounds":"(3R)-hydroxyhexadecanoyl-[ACP] => (2E)-hexadecenoyl-[ACP] + H2O"}
{"X":33858,"RHEA_ID":41910,"compounds":"(2E)-hexadecenoyl-[ACP] + H2O => (3R)-hydroxyhexadecanoyl-[ACP]"}
{"X":33859,"RHEA_ID":31944,"DIRECTION":"LR","MASTER_ID":31943,"metacyc":"RXN-12848","compounds":"cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (25S)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":33860,"RHEA_ID":31945,"compounds":"(25S)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":33861,"RHEA_ID":41913,"compounds":"(2E)-hexadecenoyl-[ACP] + H(+) + NADPH => hexadecanoyl-[ACP] + NADP(+)"}
{"X":33862,"RHEA_ID":41914,"compounds":"hexadecanoyl-[ACP] + NADP(+) => (2E)-hexadecenoyl-[ACP] + H(+) + NADPH"}
{"X":33863,"RHEA_ID":41915,"compounds":"(2E)-hexadecenoyl-[ACP] + H(+) + NADPH <=> hexadecanoyl-[ACP] + NADP(+)"}
{"X":33864,"RHEA_ID":31949,"compounds":"ent-isokauren-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-isokaurene + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":33865,"RHEA_ID":41917,"compounds":"H(+) + hexadecanoyl-[ACP] + malonyl-[ACP] => 3-oxooctadecanoyl-[ACP] + CO2 + holo-[ACP]"}
{"X":33866,"RHEA_ID":31951,"DIRECTION":"UN","MASTER_ID":31951,"ec":"1.14.14.111","compounds":"9beta-pimara-7,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 9beta-pimara-7,15-dien-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}
{"X":33867,"RHEA_ID":31952,"DIRECTION":"LR","MASTER_ID":31951,"metacyc":"RXN-12883","compounds":"9beta-pimara-7,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-dien-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}
{"X":33868,"RHEA_ID":31953,"compounds":"9beta-pimara-7,15-dien-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]"}
{"X":33869,"RHEA_ID":41921,"compounds":"3-oxooctadecanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxyoctadecanoyl-[ACP] + NADP(+)"}
{"X":33870,"RHEA_ID":41922,"compounds":"(3R)-hydroxyoctadecanoyl-[ACP] + NADP(+) => 3-oxooctadecanoyl-[ACP] + H(+) + NADPH"}
{"X":33871,"RHEA_ID":41923,"compounds":"3-oxooctadecanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxyoctadecanoyl-[ACP] + NADP(+)"}
{"X":33872,"RHEA_ID":31957,"compounds":"9beta-pimara-7,15-dien-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":33873,"RHEA_ID":41925,"compounds":"(3R)-hydroxyoctadecanoyl-[ACP] => (2E)-octadecenoyl-[ACP] + H2O"}
{"X":33874,"RHEA_ID":41926,"compounds":"(2E)-octadecenoyl-[ACP] + H2O => (3R)-hydroxyoctadecanoyl-[ACP]"}
{"X":33875,"RHEA_ID":41927,"compounds":"(3R)-hydroxyoctadecanoyl-[ACP] <=> (2E)-octadecenoyl-[ACP] + H2O"}
{"X":33876,"RHEA_ID":31961,"compounds":"9beta-pimara-7,15-dien-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-dien-19-ol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":33877,"RHEA_ID":41929,"compounds":"(2E)-octadecenoyl-[ACP] + H(+) + NADPH => NADP(+) + octadecanoyl-[ACP]"}
{"X":33878,"RHEA_ID":31963,"compounds":"9beta-pimara-7,15-dien-19-al + O2 + reduced [NADPH--hemoprotein reductase] = 9beta-pimara-7,15-dien-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":33879,"RHEA_ID":41931,"compounds":"(2E)-octadecenoyl-[ACP] + H(+) + NADPH <=> NADP(+) + octadecanoyl-[ACP]"}
{"X":33880,"RHEA_ID":31965,"compounds":"9beta-pimara-7,15-dien-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-dien-19-al + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":33881,"RHEA_ID":41933,"DIRECTION":"LR","MASTER_ID":41932,"ecocyc":"RXN-9549","metacyc":"RXN-9549","compounds":"H2O + hexadecanoyl-[ACP] => H(+) + hexadecanoate + holo-[ACP]"}
{"X":33882,"RHEA_ID":31967,"DIRECTION":"UN","MASTER_ID":31967,"ec":"1.14.14.112","compounds":"ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase] = ent-11beta-hydroxycassa-12,15-diene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":33883,"RHEA_ID":51900,"compounds":"H2O + N(1)-acetylspermidine = acetate + spermidine"}
{"X":33884,"RHEA_ID":31969,"compounds":"ent-11beta-hydroxycassa-12,15-diene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":33885,"RHEA_ID":41937,"compounds":"a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + UDP-alpha-D-galactose => a neolactoside IV(3)-beta-[Gal-beta-(1->3)-GlcNAc]-nLc4Cer(d18:1(4E)) + H(+) + UDP"}
{"X":33886,"RHEA_ID":31971,"DIRECTION":"UN","MASTER_ID":31971,"ec":"1.14.13.146","compounds":"10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + NADPH + O2 = 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + H2O + NADP(+)"}
{"X":33887,"RHEA_ID":51904,"DIRECTION":"UN","MASTER_ID":51904,"ec":"6.3.2.17","compounds":"10-formyltetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate = 10-formyltetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate"}
{"X":33888,"RHEA_ID":31973,"compounds":"10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + H2O + NADP(+) => 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + NADPH + O2"}
{"X":33889,"RHEA_ID":41941,"DIRECTION":"LR","MASTER_ID":41940,"metacyc":"RXN-15002","compounds":"[amino group carrier protein]-C-terminal-L-glutamate + ATP + L-2-aminoadipate => [amino group carrier protein]-C-terminal-N-(1,5-dicarboxypentan-1-yl)-L-glutamine + ADP + H(+) + phosphate"}
{"X":33890,"RHEA_ID":31975,"DIRECTION":"UN","MASTER_ID":31975,"ec":"1.14.13.147","compounds":"H(+) + NADPH + O2 + taxusin = 7beta-hydroxytaxusin + H2O + NADP(+)"}
{"X":33891,"RHEA_ID":62273,"compounds":"4 (R)-2-hydroxy-3-methylbutyrate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine => 8 AMP + bassianolide + 8 diphosphate + 8 H(+) + 4 S-adenosyl-L-homocysteine"}
{"X":33892,"RHEA_ID":31977,"compounds":"7beta-hydroxytaxusin + H2O + NADP(+) => H(+) + NADPH + O2 + taxusin"}
{"X":33893,"RHEA_ID":41945,"DIRECTION":"LR","MASTER_ID":41944,"metacyc":"RXN-5182","compounds":"[amino group carrier protein]-C-terminal-N-(1,5-dicarboxypentan-1-yl)-L-glutamine + ATP => [amino group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + ADP"}
{"X":33894,"RHEA_ID":31979,"DIRECTION":"UN","MASTER_ID":31979,"ec":"1.14.13.148","compounds":"NADPH + O2 + trimethylamine = H2O + NADP(+) + trimethylamine N-oxide"}
{"X":33895,"RHEA_ID":62277,"compounds":"3 (R)-2-hydroxy-3-methylbutyrate + 6 ATP + 3 L-phenylalanine + 3 S-adenosyl-L-methionine => 6 AMP + beauvericin + 6 diphosphate + 6 H(+) + 3 S-adenosyl-L-homocysteine"}
{"X":33896,"RHEA_ID":31981,"compounds":"H2O + NADP(+) + trimethylamine N-oxide => NADPH + O2 + trimethylamine"}
{"X":33897,"RHEA_ID":31983,"compounds":"abieta-7,13-dien-18-ol + O2 + reduced [NADPH--hemoprotein reductase] = abieta-7,13-dien-18,18-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":33898,"RHEA_ID":31985,"compounds":"abieta-7,13-dien-18,18-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => abieta-7,13-dien-18-ol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":33899,"RHEA_ID":41953,"compounds":"2-oxoglutarate + [amino group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate => [amino group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamate"}
{"X":33900,"RHEA_ID":31987,"DIRECTION":"UN","MASTER_ID":31987,"ec":"5.4.99.57","compounds":"(S)-2,3-epoxysqualene = baruol"}
{"X":33901,"RHEA_ID":62289,"compounds":"(8aS)-3-[(1H-indol-3-yl)methyl]-1H,2H,6H,7H,8H,8aH-pyrrolo[1,2-a]pyrazin-1-one + dimethylallyl diphosphate => (8aS)-3-{[2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl]methyl}-1H,2H,6H,7H,8H,8aH-pyrrolo[1,2-a]pyrazin-1-one + diphosphate"}
{"X":33902,"RHEA_ID":31989,"compounds":"baruol => (S)-2,3-epoxysqualene"}
{"X":33903,"RHEA_ID":41957,"DIRECTION":"LR","MASTER_ID":41956,"metacyc":"RXN-12059","compounds":"2',3'-cyclic CMP + H2O => cytidine 2'-phosphate + H(+)"}
{"X":33904,"RHEA_ID":31991,"DIRECTION":"UN","MASTER_ID":31991,"ec":"4.2.3.102","compounds":"(2E,6E)-farnesyl diphosphate = diphosphate + sesquithujene"}
{"X":33905,"RHEA_ID":51924,"DIRECTION":"UN","MASTER_ID":51924,"ec":"1.3.99.38","compounds":"AH2 + menaquinone-9 = A + beta-dihydromenaquinone-9"}
{"X":33906,"RHEA_ID":31993,"compounds":"diphosphate + sesquithujene => (2E,6E)-farnesyl diphosphate"}
{"X":33907,"RHEA_ID":41961,"compounds":"ganglioside GA2 (d18:1(4E)) + UDP-alpha-D-galactose => ganglioside GA1 (d18:1(4E)) + H(+) + UDP"}
{"X":33908,"RHEA_ID":31995,"DIRECTION":"UN","MASTER_ID":31995,"ec":"4.2.3.101","compounds":"(2E,6E)-farnesyl diphosphate = 7-epi-sesquithujene + diphosphate"}
{"X":33909,"RHEA_ID":51928,"DIRECTION":"UN","MASTER_ID":51928,"ec":"1.5.1.51","compounds":"H2O + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + NAD(+) = (S)-2,3-diaminopropanoate + 2-oxoglutarate + H(+) + NADH"}
{"X":33910,"RHEA_ID":31997,"compounds":"7-epi-sesquithujene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":33911,"RHEA_ID":41965,"compounds":"butanoyl-CoA + O2 => (2E)-butenoyl-CoA + H2O2"}
{"X":33912,"RHEA_ID":31999,"DIRECTION":"UN","MASTER_ID":31999,"ec":"4.2.3.100","compounds":"(2E,6E)-farnesyl diphosphate = bicyclogermacrene + diphosphate"}
{"X":33913,"RHEA_ID":51932,"DIRECTION":"UN","MASTER_ID":51932,"ec":"1.8.2.5","compounds":"2 [Fe(III)-cytochrome c3] + hydrogen sulfide + sulfite = 2 [Fe(II)-cytochrome c3] + thiosulfate"}
{"X":33914,"RHEA_ID":32001,"compounds":"bicyclogermacrene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":33915,"RHEA_ID":41969,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GM1b (d18:1(4E)) => CMP + ganglioside GD1aalpha (d18:1(4E)) + H(+)"}
{"X":33916,"RHEA_ID":32003,"compounds":"(+)-copalyl diphosphate = diphosphate + isopimara-8(14),15-diene"}
{"X":33917,"RHEA_ID":41971,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GM1b (d18:1(4E)) <=> CMP + ganglioside GD1aalpha (d18:1(4E)) + H(+)"}
{"X":33918,"RHEA_ID":32005,"compounds":"diphosphate + isopimara-8(14),15-diene => (+)-copalyl diphosphate"}
{"X":33919,"RHEA_ID":32006,"compounds":"(+)-copalyl diphosphate <=> diphosphate + isopimara-8(14),15-diene"}
{"X":33920,"RHEA_ID":32007,"compounds":"9alpha-copalyl diphosphate = diphosphate + isopimara-8(14),15-diene"}
{"X":33921,"RHEA_ID":41975,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GD1a (18:1(4E)) <=> CMP + ganglioside GT1aalpha (d18:1(4E)) + H(+)"}
{"X":33922,"RHEA_ID":32009,"compounds":"diphosphate + isopimara-8(14),15-diene => 9alpha-copalyl diphosphate"}
{"X":33923,"RHEA_ID":32010,"compounds":"9alpha-copalyl diphosphate <=> diphosphate + isopimara-8(14),15-diene"}
{"X":33924,"RHEA_ID":32011,"DIRECTION":"UN","MASTER_ID":32011,"ec":"4.2.3.98","compounds":"(2E,6E)-farnesyl diphosphate + H2O = (+)-T-muurolol + diphosphate"}
{"X":33925,"RHEA_ID":32012,"DIRECTION":"LR","MASTER_ID":32011,"metacyc":"RXN-12833","compounds":"(2E,6E)-farnesyl diphosphate + H2O => (+)-T-muurolol + diphosphate"}
{"X":33926,"RHEA_ID":41980,"compounds":"3alpha-hydroxy-5alpha-pregnan-20-one + NAD(+) = 5alpha-pregnane-3,20-dione + H(+) + NADH"}
{"X":33927,"RHEA_ID":51946,"compounds":"2 H(+) + roseoflavin + 2 S-adenosyl-L-homocysteine => 8-amino-8-demethylriboflavin + 2 S-adenosyl-L-methionine"}
{"X":33928,"RHEA_ID":32015,"DIRECTION":"UN","MASTER_ID":32015,"ec":"4.2.3.97","compounds":"(2E,6E)-farnesyl diphosphate = (-)-delta-cadinene + diphosphate"}
{"X":33929,"RHEA_ID":32016,"DIRECTION":"LR","MASTER_ID":32015,"metacyc":"RXN-12832","compounds":"(2E,6E)-farnesyl diphosphate => (-)-delta-cadinene + diphosphate"}
{"X":33930,"RHEA_ID":41984,"compounds":"NAD(+) + propan-2-ol = acetone + H(+) + NADH"}
{"X":33931,"RHEA_ID":41985,"compounds":"NAD(+) + propan-2-ol => acetone + H(+) + NADH"}
{"X":33932,"RHEA_ID":32019,"DIRECTION":"UN","MASTER_ID":32019,"ec":"4.2.3.128","compounds":"(2E,6E)-farnesyl diphosphate = beta-cubebene + diphosphate"}
{"X":33933,"RHEA_ID":32020,"DIRECTION":"LR","MASTER_ID":32019,"metacyc":"RXN-8604","compounds":"(2E,6E)-farnesyl diphosphate => beta-cubebene + diphosphate"}
{"X":33934,"RHEA_ID":41988,"compounds":"3beta-hydroxy-5alpha-pregnane-20-one + NAD(+) = 5alpha-pregnane-3,20-dione + H(+) + NADH"}
{"X":33935,"RHEA_ID":51954,"compounds":"2-hydroxy-2-methylpropanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (E)-2-methylpropanal oxime + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":33936,"RHEA_ID":32023,"DIRECTION":"UN","MASTER_ID":32023,"ec":"4.2.3.96","compounds":"(2E,6E)-farnesyl diphosphate + H2O = avermitilol + diphosphate"}
{"X":33937,"RHEA_ID":32024,"DIRECTION":"LR","MASTER_ID":32023,"metacyc":"RXN-12831","compounds":"(2E,6E)-farnesyl diphosphate + H2O => avermitilol + diphosphate"}
{"X":33938,"RHEA_ID":32025,"compounds":"avermitilol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}
{"X":33939,"RHEA_ID":62327,"compounds":"(+)-malbrancheamide B + chloride + FAD + 2 H(+) <=> (+)-malbrancheamide + FADH2"}
{"X":33940,"RHEA_ID":41994,"compounds":"5alpha-androstan-3,17-dione + H(+) + NADH => 17beta-hydroxy-5alpha-androstan-3-one + NAD(+)"}
{"X":33941,"RHEA_ID":32028,"DIRECTION":"LR","MASTER_ID":32027,"metacyc":"RXN-8426","compounds":"(2E,6E)-farnesyl diphosphate => (-)-alpha-cuprenene + diphosphate"}
{"X":33942,"RHEA_ID":32029,"compounds":"(-)-alpha-cuprenene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":33943,"RHEA_ID":51962,"compounds":"2-methylpropanenitrile + H2O => (Z)-2-methylpropanal oxime"}
{"X":33944,"RHEA_ID":41998,"compounds":"globoside GalGb4Cer (d18:1(4E)) + H(+) + UDP => globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose"}
{"X":33945,"RHEA_ID":32032,"DIRECTION":"LR","MASTER_ID":32031,"metacyc":"RXN-10599","compounds":"(2E,6E)-farnesyl diphosphate => diphosphate + gamma-curcumene"}
{"X":33946,"RHEA_ID":32033,"compounds":"diphosphate + gamma-curcumene => (2E,6E)-farnesyl diphosphate"}
{"X":33947,"RHEA_ID":42001,"compounds":"a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose => H(+) + isogloboside iGb3Cer (d18:1(4E)) + UDP"}
{"X":33948,"RHEA_ID":32035,"DIRECTION":"UN","MASTER_ID":32035,"ec":"3.7.1.17","compounds":"(1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H2O = (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + H(+)"}
{"X":33949,"RHEA_ID":32036,"DIRECTION":"LR","MASTER_ID":32035,"metacyc":"RXN-12718","compounds":"(1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H2O => (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + H(+)"}
{"X":33950,"RHEA_ID":32037,"compounds":"(2Z,4Z)-2-hydroxyhexa-2,4-dienoate + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + H(+) => (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H2O"}
{"X":33951,"RHEA_ID":51970,"compounds":"(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate => (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2"}
{"X":33952,"RHEA_ID":32039,"DIRECTION":"UN","MASTER_ID":32039,"ec":"3.6.1.61","compounds":"H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate = AMP + ATP + 2 H(+)"}
{"X":33953,"RHEA_ID":32040,"compounds":"H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate => AMP + ATP + 2 H(+)"}
{"X":33954,"RHEA_ID":32041,"compounds":"AMP + ATP + 2 H(+) => H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate"}
{"X":33955,"RHEA_ID":51974,"compounds":"an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => an L-polyhomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}
{"X":33956,"RHEA_ID":32043,"DIRECTION":"UN","MASTER_ID":32043,"ec":"3.6.1.61","compounds":"H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate = 2 ATP + 2 H(+)"}
{"X":33957,"RHEA_ID":32044,"compounds":"H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate => 2 ATP + 2 H(+)"}
{"X":33958,"RHEA_ID":32045,"compounds":"2 ATP + 2 H(+) => H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate"}
{"X":33959,"RHEA_ID":42013,"compounds":"cortisol + NAD(+) => 11beta,17alpha-dihydroxypregn-4-ene-3,20,21-trione + H(+) + NADH"}
{"X":33960,"RHEA_ID":42014,"compounds":"11beta,17alpha-dihydroxypregn-4-ene-3,20,21-trione + H(+) + NADH => cortisol + NAD(+)"}
{"X":33961,"RHEA_ID":32048,"compounds":"H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate => adenosine 5'-pentaphosphate + AMP + 2 H(+)"}
{"X":33962,"RHEA_ID":32049,"compounds":"adenosine 5'-pentaphosphate + AMP + 2 H(+) => H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate"}
{"X":33963,"RHEA_ID":51982,"compounds":"an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + H2O => an L-N,N-dihydroxypolyhomomethionine + H(+)"}
{"X":33964,"RHEA_ID":42018,"compounds":"17alpha-hydroxypregn-4-en-3,11,20-trione-21-al + H(+) + NADH => cortisone + NAD(+)"}
{"X":33965,"RHEA_ID":32052,"compounds":"H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate => adenosine 5'-tetraphosphate + AMP + 2 H(+)"}
{"X":33966,"RHEA_ID":32053,"compounds":"adenosine 5'-tetraphosphate + AMP + 2 H(+) => H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate"}
{"X":33967,"RHEA_ID":51986,"compounds":"all-trans-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":33968,"RHEA_ID":42022,"compounds":"H(+) + NADH + pregn-4-ene-3,11,20,21-tetraone => 11-dehydrocorticosterone + NAD(+)"}
{"X":33969,"RHEA_ID":32060,"DIRECTION":"LR","MASTER_ID":32059,"metacyc":"RXN-14901","compounds":"(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + H2O => (R)-glycerate + D-glucose"}
{"X":33970,"RHEA_ID":32061,"compounds":"(R)-glycerate + D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + H2O"}
{"X":33971,"RHEA_ID":42025,"compounds":"3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD(+) => 3beta-hydroxy-7-oxo-5beta-cholan-24-oate + H(+) + NADH"}
{"X":33972,"RHEA_ID":42026,"compounds":"3beta-hydroxy-7-oxo-5beta-cholan-24-oate + H(+) + NADH => 3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD(+)"}
{"X":33973,"RHEA_ID":32064,"DIRECTION":"LR","MASTER_ID":32063,"ecocyc":"RXN-12816","metacyc":"RXN-12816","reactome":"R-HSA-2395876.3","compounds":"8-oxo-dGDP + H2O => 8-oxo-dGMP + H(+) + phosphate"}
{"X":33974,"RHEA_ID":32064,"DIRECTION":"LR","MASTER_ID":32063,"ecocyc":"RXN-12816","metacyc":"RXN-12816","reactome":"R-HSA-2395879.3","compounds":"8-oxo-dGDP + H2O => 8-oxo-dGMP + H(+) + phosphate"}
{"X":33975,"RHEA_ID":42029,"compounds":"NAD(+) + ursodeoxycholate => 7-oxolithocholate + H(+) + NADH"}
{"X":33976,"RHEA_ID":32067,"DIRECTION":"UN","MASTER_ID":32067,"ec":"3.5.4.32","compounds":"8-oxoguanine + H(+) + H2O = NH4(+) + urate"}
{"X":33977,"RHEA_ID":32068,"compounds":"8-oxoguanine + H(+) + H2O => NH4(+) + urate"}
{"X":33978,"RHEA_ID":32069,"compounds":"NH4(+) + urate => 8-oxoguanine + H(+) + H2O"}
{"X":33979,"RHEA_ID":32071,"compounds":"geranylgeranyl diphosphate = (13E)-labda-7,13-dien-15-yl diphosphate"}
{"X":33980,"RHEA_ID":32072,"DIRECTION":"LR","MASTER_ID":32071,"metacyc":"RXN-14242","compounds":"geranylgeranyl diphosphate => (13E)-labda-7,13-dien-15-yl diphosphate"}
{"X":33981,"RHEA_ID":42037,"compounds":"chenodeoxycholate + NAD(+) => 7-oxolithocholate + H(+) + NADH"}
{"X":33982,"RHEA_ID":32074,"compounds":"geranylgeranyl diphosphate <=> (13E)-labda-7,13-dien-15-yl diphosphate"}
{"X":33983,"RHEA_ID":32075,"DIRECTION":"UN","MASTER_ID":32075,"ec":"3.1.7.10","compounds":"geranylgeranyl diphosphate + H2O = (13E)-labda-7,13-dien-15-ol + diphosphate"}
{"X":33984,"RHEA_ID":32076,"DIRECTION":"LR","MASTER_ID":32075,"metacyc":"RXN-12892","compounds":"geranylgeranyl diphosphate + H2O => (13E)-labda-7,13-dien-15-ol + diphosphate"}
{"X":33985,"RHEA_ID":32077,"compounds":"(13E)-labda-7,13-dien-15-ol + diphosphate => geranylgeranyl diphosphate + H2O"}
{"X":33986,"RHEA_ID":52011,"compounds":"8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + ATP + CoA <=> 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate"}
{"X":33987,"RHEA_ID":32079,"compounds":"(13E)-labda-7,13-dien-15-yl diphosphate + H2O = (13E)-labda-7,13-dien-15-ol + diphosphate"}
{"X":33988,"RHEA_ID":32080,"DIRECTION":"LR","MASTER_ID":32079,"metacyc":"RXN-14243","compounds":"(13E)-labda-7,13-dien-15-yl diphosphate + H2O => (13E)-labda-7,13-dien-15-ol + diphosphate"}
{"X":33989,"RHEA_ID":42045,"compounds":"GDP-beta-L-fucose + globoside GalGb4Cer (d18:1(4E)) => GDP + globoside Globo-H (d18:1(4E)) + H(+)"}
{"X":33990,"RHEA_ID":32082,"compounds":"(13E)-labda-7,13-dien-15-yl diphosphate + H2O <=> (13E)-labda-7,13-dien-15-ol + diphosphate"}
{"X":33991,"RHEA_ID":32083,"DIRECTION":"UN","MASTER_ID":32083,"ec":"2.7.7.81","compounds":"CTP + pseudaminate = CMP-pseudaminate + diphosphate"}
{"X":33992,"RHEA_ID":32084,"DIRECTION":"LR","MASTER_ID":32083,"metacyc":"RXN-10003","compounds":"CTP + pseudaminate => CMP-pseudaminate + diphosphate"}
{"X":33993,"RHEA_ID":42049,"compounds":"3-hydroxybutanoyl-CoA + NAD(+) => acetoacetyl-CoA + H(+) + NADH"}
{"X":33994,"RHEA_ID":52019,"compounds":"14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + ATP + CoA <=> 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoyl-CoA + AMP + diphosphate"}
{"X":33995,"RHEA_ID":32087,"DIRECTION":"UN","MASTER_ID":32087,"ec":"2.5.1.98","compounds":"[4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphoenolpyruvate = [4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-(S)-4,6-CH3(COO(-))C-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphate"}
{"X":33996,"RHEA_ID":32088,"DIRECTION":"LR","MASTER_ID":32087,"metacyc":"RXN-12809","compounds":"[4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphoenolpyruvate => [4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-(S)-4,6-CH3(COO(-))C-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphate"}
{"X":33997,"RHEA_ID":42053,"compounds":"9-cis-retinol + NAD(+) => 9-cis-retinal + H(+) + NADH"}
{"X":33998,"RHEA_ID":42054,"compounds":"9-cis-retinal + H(+) + NADH => 9-cis-retinol + NAD(+)"}
{"X":33999,"RHEA_ID":32091,"DIRECTION":"UN","MASTER_ID":32091,"ec":"2.4.1.278","compounds":"3-O-alpha-L-mycarosylerythronolide B + dTDP-alpha-D-desosamine = dTDP + erythromycin D + H(+)"}
{"X":34000,"RHEA_ID":32092,"DIRECTION":"LR","MASTER_ID":32091,"metacyc":"RXN-12808","compounds":"3-O-alpha-L-mycarosylerythronolide B + dTDP-alpha-D-desosamine => dTDP + erythromycin D + H(+)"}
{"X":34001,"RHEA_ID":42057,"DIRECTION":"LR","MASTER_ID":42056,"metacyc":"RXN-12577","compounds":"13-cis-retinol + NAD(+) => 13-cis-retinal + H(+) + NADH"}
{"X":34002,"RHEA_ID":52027,"compounds":"(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2 <=> 18S-resolvin E2 + A + H2O"}
{"X":34003,"RHEA_ID":32095,"DIRECTION":"UN","MASTER_ID":32095,"ec":"2.3.1.197","compounds":"acetyl-CoA + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose = CoA + dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactopyranose + H(+)"}
{"X":34004,"RHEA_ID":32096,"DIRECTION":"LR","MASTER_ID":32095,"metacyc":"RXN-12806","compounds":"acetyl-CoA + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose => CoA + dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactopyranose + H(+)"}
{"X":34005,"RHEA_ID":42061,"DIRECTION":"LR","MASTER_ID":42060,"reactome":"R-HSA-5362721.1","compounds":"11-cis-retinol + NAD(+) => 11-cis-retinal + H(+) + NADH"}
{"X":34006,"RHEA_ID":42062,"compounds":"11-cis-retinal + H(+) + NADH => 11-cis-retinol + NAD(+)"}
{"X":34007,"RHEA_ID":52032,"DIRECTION":"UN","MASTER_ID":52032,"ec":"3.5.1.127","compounds":"H2O + L-isoleucine-(+)-7-isojasmonate = (+)-7-isojasmonate + L-isoleucine"}
{"X":34008,"RHEA_ID":32100,"DIRECTION":"LR","MASTER_ID":32099,"metacyc":"RXN-6687","compounds":"S-adenosyl-L-methionine + TRIBOA beta-D-glucoside => DIMBOA beta-D-glucoside + H(+) + S-adenosyl-L-homocysteine"}
{"X":34009,"RHEA_ID":32101,"compounds":"DIMBOA beta-D-glucoside + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + TRIBOA beta-D-glucoside"}
{"X":34010,"RHEA_ID":42066,"compounds":"2',3'-cGAMP + 2 diphosphate => ATP + GTP"}
{"X":34011,"RHEA_ID":52036,"DIRECTION":"UN","MASTER_ID":52036,"ec":"3.5.1.127","compounds":"H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate = L-isoleucine + tuberonate"}
{"X":34012,"RHEA_ID":32104,"DIRECTION":"LR","MASTER_ID":32103,"metacyc":"RXN-12805","compounds":"2 S-adenosyl-L-methionine + trans-resveratrol => 2 H(+) + pterostilbene + 2 S-adenosyl-L-homocysteine"}
{"X":34013,"RHEA_ID":42069,"compounds":"(3R,5R)-clavulanate-9-aldehyde + H(+) + NADPH => clavulanate + NADP(+)"}
{"X":34014,"RHEA_ID":42070,"compounds":"clavulanate + NADP(+) => (3R,5R)-clavulanate-9-aldehyde + H(+) + NADPH"}
{"X":34015,"RHEA_ID":32107,"compounds":"3-methoxy-4',5-dihydroxy-trans-stilbene + S-adenosyl-L-methionine = H(+) + pterostilbene + S-adenosyl-L-homocysteine"}
{"X":34016,"RHEA_ID":32108,"DIRECTION":"LR","MASTER_ID":32107,"metacyc":"RXN-11896","compounds":"3-methoxy-4',5-dihydroxy-trans-stilbene + S-adenosyl-L-methionine => H(+) + pterostilbene + S-adenosyl-L-homocysteine"}
{"X":34017,"RHEA_ID":42073,"DIRECTION":"LR","MASTER_ID":42072,"metacyc":"HYDROXYHEPTA-DIENEDIOATE-HYDROXY-RXN","compounds":"(4Z)-2-oxohept-4-enedioate + H2O => (4S)-4-hydroxy-2-oxoheptanedioate"}
{"X":34018,"RHEA_ID":42074,"compounds":"(4S)-4-hydroxy-2-oxoheptanedioate => (4Z)-2-oxohept-4-enedioate + H2O"}
{"X":34019,"RHEA_ID":32111,"compounds":"S-adenosyl-L-methionine + trans-resveratrol = 3-methoxy-4',5-dihydroxy-trans-stilbene + H(+) + S-adenosyl-L-homocysteine"}
{"X":34020,"RHEA_ID":32112,"DIRECTION":"LR","MASTER_ID":32111,"metacyc":"RXN-11895","compounds":"S-adenosyl-L-methionine + trans-resveratrol => 3-methoxy-4',5-dihydroxy-trans-stilbene + H(+) + S-adenosyl-L-homocysteine"}
{"X":34021,"RHEA_ID":52046,"compounds":"H(+) + mogroside IE + UDP => mogrol + UDP-alpha-D-glucose"}
{"X":34022,"RHEA_ID":42078,"compounds":"2-hydroxyglutaryl-CoA + acetate => 2-hydroxyglutarate + acetyl-CoA"}
{"X":34023,"RHEA_ID":32115,"DIRECTION":"UN","MASTER_ID":32115,"ec":"1.14.11.59","compounds":"2-oxoglutarate + DIBOA beta-D-glucoside + O2 = CO2 + succinate + TRIBOA beta-D-glucoside"}
{"X":34024,"RHEA_ID":32116,"DIRECTION":"LR","MASTER_ID":32115,"metacyc":"RXN-6685","compounds":"2-oxoglutarate + DIBOA beta-D-glucoside + O2 => CO2 + succinate + TRIBOA beta-D-glucoside"}
{"X":34025,"RHEA_ID":52050,"compounds":"(9Z)-octadecenoate + 9-hydroxy-octadecanoate + H(+) => 9-(9Z-octadecenoyloxy)-octadecanoate + H2O"}
{"X":34026,"RHEA_ID":42082,"compounds":"all-trans-retinoate + 2 H(+) + NADH => all-trans-retinal + H2O + NAD(+)"}
{"X":34027,"RHEA_ID":32119,"DIRECTION":"UN","MASTER_ID":32119,"ec":"2.5.1.135","compounds":"GDP-valienol + validamine 7-phosphate = GDP + H(+) + validoxylamine A 7'-phosphate"}
{"X":34028,"RHEA_ID":32120,"DIRECTION":"LR","MASTER_ID":32119,"metacyc":"RXN-17379","compounds":"GDP-valienol + validamine 7-phosphate => GDP + H(+) + validoxylamine A 7'-phosphate"}
{"X":34029,"RHEA_ID":42085,"DIRECTION":"LR","MASTER_ID":42084,"reactome":"R-HSA-5696101.1","compounds":"9-cis-retinal + H2O + NAD(+) => 9-cis-retinoate + 2 H(+) + NADH"}
{"X":34030,"RHEA_ID":42086,"compounds":"9-cis-retinoate + 2 H(+) + NADH => 9-cis-retinal + H2O + NAD(+)"}
{"X":34031,"RHEA_ID":32123,"compounds":"citrate(in) + H(+)(in) = citrate(out) + H(+)(out)"}
{"X":34032,"RHEA_ID":32124,"compounds":"citrate(in) + H(+)(in) => citrate(out) + H(+)(out)"}
{"X":34033,"RHEA_ID":52058,"compounds":"12-hydroxyoctadecanoate + H(+) + hexadecanoate => 12-hexadecanoyloxy-octadecanoate + H2O"}
{"X":34034,"RHEA_ID":32126,"compounds":"citrate(in) + H(+)(in) <=> citrate(out) + H(+)(out)"}
{"X":34035,"RHEA_ID":32127,"DIRECTION":"UN","MASTER_ID":32127,"ec":"1.14.11.56","compounds":"2-oxoglutarate + L-proline + O2 = cis-4-hydroxy-L-proline + CO2 + succinate"}
{"X":34036,"RHEA_ID":32128,"DIRECTION":"LR","MASTER_ID":32127,"metacyc":"RXN-14244","compounds":"2-oxoglutarate + L-proline + O2 => cis-4-hydroxy-L-proline + CO2 + succinate"}
{"X":34037,"RHEA_ID":42093,"compounds":"all-trans-retinol + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-retinal + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":34038,"RHEA_ID":32130,"compounds":"2-oxoglutarate + L-proline + O2 <=> cis-4-hydroxy-L-proline + CO2 + succinate"}
{"X":34039,"RHEA_ID":32131,"DIRECTION":"UN","MASTER_ID":32131,"ec":"4.1.1.94","compounds":"(2S)-ethylmalonyl-CoA + H(+) = butanoyl-CoA + CO2"}
{"X":34040,"RHEA_ID":32132,"compounds":"(2S)-ethylmalonyl-CoA + H(+) => butanoyl-CoA + CO2"}
{"X":34041,"RHEA_ID":42097,"DIRECTION":"LR","MASTER_ID":42096,"metacyc":"RXN-15284","compounds":"ATP + carbamoyl phosphate + H2O + tobramycin => AMP + diphosphate + H(+) + nebramycin 5' + phosphate"}
{"X":34042,"RHEA_ID":42098,"compounds":"AMP + diphosphate + H(+) + nebramycin 5' + phosphate => ATP + carbamoyl phosphate + H2O + tobramycin"}
{"X":34043,"RHEA_ID":32135,"DIRECTION":"UN","MASTER_ID":32135,"ec":"1.2.7.1","compounds":"2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2 + H(+) + propanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":34044,"RHEA_ID":32136,"compounds":"2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] => CO2 + H(+) + propanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":34045,"RHEA_ID":52070,"compounds":"(9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H(+) => 9-(9Z-hexadecenoyloxy)-octadecanoate + H2O"}
{"X":34046,"RHEA_ID":42102,"compounds":"6''-O-carbamoylkanamycin A + AMP + diphosphate + H(+) + phosphate => ATP + carbamoyl phosphate + H2O + kanamycin A"}
{"X":34047,"RHEA_ID":32139,"DIRECTION":"UN","MASTER_ID":32139,"ec":"6.2.1.n3","compounds":"ATP + CoA + malonate = AMP + diphosphate + malonyl-CoA"}
{"X":34048,"RHEA_ID":32140,"compounds":"ATP + CoA + malonate => AMP + diphosphate + malonyl-CoA"}
{"X":34049,"RHEA_ID":52074,"compounds":"(9Z)-hexadecenoate + 12-hydroxyoctadecanoate + H(+) => 12-(9Z-hexadecenoyloxy)-octadecanoate + H2O"}
{"X":34050,"RHEA_ID":32142,"compounds":"ATP + CoA + malonate <=> AMP + diphosphate + malonyl-CoA"}
{"X":34051,"RHEA_ID":32143,"compounds":"L-arginine(in) = L-arginine(out)"}
{"X":34052,"RHEA_ID":32144,"DIRECTION":"LR","MASTER_ID":32143,"reactome":"R-HSA-375770.1","compounds":"L-arginine(in) => L-arginine(out)"}
{"X":34053,"RHEA_ID":42109,"compounds":"(20S)-hydroxypregn-4-en-3-one + NAD(+) => H(+) + NADH + progesterone"}
{"X":34054,"RHEA_ID":32144,"DIRECTION":"LR","MASTER_ID":32143,"reactome":"R-HSA-375790.1","compounds":"L-arginine(in) => L-arginine(out)"}
{"X":34055,"RHEA_ID":32144,"DIRECTION":"LR","MASTER_ID":32143,"reactome":"R-HSA-375768.1","compounds":"L-arginine(in) => L-arginine(out)"}
{"X":34056,"RHEA_ID":32144,"DIRECTION":"LR","MASTER_ID":32143,"reactome":"R-HSA-352136.1","compounds":"L-arginine(in) => L-arginine(out)"}
{"X":34057,"RHEA_ID":52082,"compounds":"12-hydroxyoctadecanoate + H(+) + octadecanoate => 12-octadecanoyloxy-octadecanoate + H2O"}
{"X":34058,"RHEA_ID":32145,"DIRECTION":"RL","MASTER_ID":32143,"reactome":"R-HSA-8932851.1","compounds":"L-arginine(out) => L-arginine(in)"}
{"X":34059,"RHEA_ID":32145,"DIRECTION":"RL","MASTER_ID":32143,"reactome":"R-HSA-8952726.1","compounds":"L-arginine(out) => L-arginine(in)"}
{"X":34060,"RHEA_ID":32146,"compounds":"L-arginine(in) <=> L-arginine(out)"}
{"X":34061,"RHEA_ID":52086,"compounds":"13-hydroxy-octadecanoate + H(+) + octadecanoate => 13-octadecanoyloxy-octadecanoate + H2O"}
{"X":34062,"RHEA_ID":32148,"compounds":"H2O + sepiapterin => 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + H(+)"}
{"X":34063,"RHEA_ID":32149,"compounds":"6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + H(+) => H2O + sepiapterin"}
{"X":34064,"RHEA_ID":32150,"compounds":"H2O + sepiapterin <=> 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + H(+)"}
{"X":34065,"RHEA_ID":42121,"compounds":"17beta-hydroxy-5alpha-androstan-3-one + NADP(+) => 5alpha-androstan-3,17-dione + H(+) + NADPH"}
{"X":34066,"RHEA_ID":42122,"compounds":"5alpha-androstan-3,17-dione + H(+) + NADPH => 17beta-hydroxy-5alpha-androstan-3-one + NADP(+)"}
{"X":34067,"RHEA_ID":32153,"compounds":"(12E)-9alpha-labda-8(17),12,14-triene + diphosphate => 9alpha-copalyl diphosphate"}
{"X":34068,"RHEA_ID":32154,"DIRECTION":"BI","MASTER_ID":32151,"metacyc":"RXN-12834","compounds":"9alpha-copalyl diphosphate <=> (12E)-9alpha-labda-8(17),12,14-triene + diphosphate"}
{"X":34069,"RHEA_ID":32155,"DIRECTION":"UN","MASTER_ID":32155,"ec":"2.4.99.17","compounds":"7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine = adenine + epoxyqueuosine(34) in tRNA + H(+) + L-methionine"}
{"X":34070,"RHEA_ID":42126,"compounds":"3alpha-hydroxy-5alpha-androstan-17-one + H(+) + NADH => 5alpha-androstane-3alpha,17beta-diol + NAD(+)"}
{"X":34071,"RHEA_ID":32157,"compounds":"adenine + epoxyqueuosine(34) in tRNA + H(+) + L-methionine => 7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine"}
{"X":34072,"RHEA_ID":32158,"compounds":"7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine <=> adenine + epoxyqueuosine(34) in tRNA + H(+) + L-methionine"}
{"X":34073,"RHEA_ID":42129,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoylsphinganine => a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphoethanolamine"}
{"X":34074,"RHEA_ID":42130,"compounds":"a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoylsphinganine"}
{"X":34075,"RHEA_ID":32161,"compounds":"A + H2O + queuosine(34) in tRNA => AH2 + epoxyqueuosine(34) in tRNA"}
{"X":34076,"RHEA_ID":32162,"compounds":"AH2 + epoxyqueuosine(34) in tRNA <=> A + H2O + queuosine(34) in tRNA"}
{"X":34077,"RHEA_ID":42133,"DIRECTION":"LR","MASTER_ID":42132,"metacyc":"RXN-17843","compounds":"isonocardicin C => nocardicin C"}
{"X":34078,"RHEA_ID":42134,"compounds":"nocardicin C => isonocardicin C"}
{"X":34079,"RHEA_ID":32165,"compounds":"AMP + diphosphate + H(+) + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine => ATP + citrate + N(6)-acetyl-N(6)-hydroxy-L-lysine"}
{"X":34080,"RHEA_ID":42136,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphinganine = a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphoethanolamine"}
{"X":34081,"RHEA_ID":42137,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphinganine => a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphoethanolamine"}
{"X":34082,"RHEA_ID":42138,"compounds":"a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphinganine"}
{"X":34083,"RHEA_ID":32169,"compounds":"aerobactin + AMP + diphosphate + H(+) => ATP + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine + N(6)-acetyl-N(6)-hydroxy-L-lysine"}
{"X":34084,"RHEA_ID":42140,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-4-hydroxysphinganine = a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-4-hydroxysphinganine-phosphocholine"}
{"X":34085,"RHEA_ID":42141,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-4-hydroxysphinganine => a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-4-hydroxysphinganine-phosphocholine"}
{"X":34086,"RHEA_ID":32172,"DIRECTION":"LR","MASTER_ID":32171,"metacyc":"RXN0-2042","compounds":"H(+) + NADPH + O2 + phenylacetyl-CoA => 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP(+)"}
{"X":34087,"RHEA_ID":32173,"compounds":"2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP(+) => H(+) + NADPH + O2 + phenylacetyl-CoA"}
{"X":34088,"RHEA_ID":32174,"compounds":"H(+) + NADPH + O2 + phenylacetyl-CoA <=> 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP(+)"}
{"X":34089,"RHEA_ID":42145,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoyl-4-hydroxysphinganine => a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-4-hydroxysphinganine-1-phosphoethanolamine"}
{"X":34090,"RHEA_ID":32176,"compounds":"a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose => alpha-L-fucosyl-(1->2)- beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + GDP + H(+)"}
{"X":34091,"RHEA_ID":32177,"compounds":"alpha-L-fucosyl-(1->2)- beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + GDP + H(+) => a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose"}
{"X":34092,"RHEA_ID":32178,"DIRECTION":"BI","MASTER_ID":32175,"metacyc":"GALACTOSIDE-2-L-FUCOSYLTRANSFERASE-RXN","compounds":"a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose <=> alpha-L-fucosyl-(1->2)- beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + GDP + H(+)"}
{"X":34093,"RHEA_ID":42149,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acyl-(4R)-4-hydroxysphinganine => a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoethanolamine"}
{"X":34094,"RHEA_ID":42150,"compounds":"a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acyl-(4R)-4-hydroxysphinganine"}
{"X":34095,"RHEA_ID":32181,"compounds":"dipicolinate + H(+) + NADH => (S)-2,3-dihydrodipicolinate + NAD(+)"}
{"X":34096,"RHEA_ID":32182,"compounds":"(S)-2,3-dihydrodipicolinate + NAD(+) <=> dipicolinate + H(+) + NADH"}
{"X":34097,"RHEA_ID":42153,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acyl-(4R)-4-hydroxysphinganine => a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-phosphocholine"}
{"X":34098,"RHEA_ID":42154,"compounds":"a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acyl-(4R)-4-hydroxysphinganine"}
{"X":34099,"RHEA_ID":32185,"compounds":"cholest-5-en-3-one + H2O2 => cholesterol + O2"}
{"X":34100,"RHEA_ID":42156,"compounds":"3alpha-hydroxy-5alpha-androstan-17-one + H(+) + NADPH = 5alpha-androstane-3alpha,17beta-diol + NADP(+)"}
{"X":34101,"RHEA_ID":32187,"DIRECTION":"UN","MASTER_ID":32187,"ec":"5.3.3.1","compounds":"cholest-5-en-3-one = cholest-4-en-3-one"}
{"X":34102,"RHEA_ID":42158,"compounds":"5alpha-androstane-3alpha,17beta-diol + NADP(+) => 3alpha-hydroxy-5alpha-androstan-17-one + H(+) + NADPH"}
{"X":34103,"RHEA_ID":32189,"compounds":"cholest-4-en-3-one => cholest-5-en-3-one"}
{"X":34104,"RHEA_ID":32190,"compounds":"cholest-5-en-3-one <=> cholest-4-en-3-one"}
{"X":34105,"RHEA_ID":32191,"compounds":"H2O + L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin] = 2-oxoglutarate + 2 H(+) + NH4(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":34106,"RHEA_ID":42162,"compounds":"(5Z,11Z,14Z)-eicosatrienoyl-CoA + A + 2 H2O => (11Z,14Z)-eicosadienoyl-CoA + AH2 + O2"}
{"X":34107,"RHEA_ID":32193,"compounds":"2-oxoglutarate + 2 H(+) + NH4(+) + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":34108,"RHEA_ID":42164,"DIRECTION":"UN","MASTER_ID":42164,"ec":"1.14.19.37","compounds":"(11Z,14Z,17Z)-eicosatrienoyl-CoA + AH2 + O2 = (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + A + 2 H2O"}
{"X":34109,"RHEA_ID":32195,"compounds":"abieta-7,13-dien-18,18-diol = abieta-7,13-dien-18-al + H2O"}
{"X":34110,"RHEA_ID":42166,"compounds":"(5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + A + 2 H2O => (11Z,14Z,17Z)-eicosatrienoyl-CoA + AH2 + O2"}
{"X":34111,"RHEA_ID":42168,"compounds":"20alpha-hydroxy-5beta-pregnan-3-one + NADP(+) = 5beta-pregnan-3,20-dione + H(+) + NADPH"}
{"X":34112,"RHEA_ID":32199,"DIRECTION":"UN","MASTER_ID":32199,"ec":"1.14.15.30","compounds":"androsta-1,4-diene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":34113,"RHEA_ID":42170,"compounds":"5beta-pregnan-3,20-dione + H(+) + NADPH => 20alpha-hydroxy-5beta-pregnan-3-one + NADP(+)"}
{"X":34114,"RHEA_ID":32201,"compounds":"9alpha-hydroxyandrosta-1,4-diene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => androsta-1,4-diene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":34115,"RHEA_ID":42172,"compounds":"(11Z)-eicosenoyl-CoA + AH2 + O2 = (8Z,11Z)-eicosadienoyl-CoA + A + 2 H2O"}
{"X":34116,"RHEA_ID":32203,"DIRECTION":"UN","MASTER_ID":32203,"ec":"4.2.1.88","compounds":"(R)-synephrine = (4-hydroxyphenyl)acetaldehyde + methylamine"}
{"X":34117,"RHEA_ID":32204,"DIRECTION":"LR","MASTER_ID":32203,"metacyc":"SYNEPHRINE-DEHYDRATASE-RXN","compounds":"(R)-synephrine => (4-hydroxyphenyl)acetaldehyde + methylamine"}
{"X":34118,"RHEA_ID":42175,"compounds":"(11Z)-eicosenoyl-CoA + AH2 + O2 <=> (8Z,11Z)-eicosadienoyl-CoA + A + 2 H2O"}
{"X":34119,"RHEA_ID":42176,"compounds":"(9Z)-tetradecenoyl-CoA + AH2 + O2 = (9Z,12Z)-tetradecadienoyl-CoA + A + 2 H2O"}
{"X":34120,"RHEA_ID":32207,"compounds":"(2E,4Z)-2-hydroxyhexa-2,4-dienedioate = (3Z)-2-oxohex-3-enedioate"}
{"X":34121,"RHEA_ID":42178,"compounds":"(9Z,12Z)-tetradecadienoyl-CoA + A + 2 H2O => (9Z)-tetradecenoyl-CoA + AH2 + O2"}
{"X":34122,"RHEA_ID":42179,"compounds":"(9Z)-tetradecenoyl-CoA + AH2 + O2 <=> (9Z,12Z)-tetradecadienoyl-CoA + A + 2 H2O"}
{"X":34123,"RHEA_ID":32210,"compounds":"(2E,4Z)-2-hydroxyhexa-2,4-dienedioate <=> (3Z)-2-oxohex-3-enedioate"}
{"X":34124,"RHEA_ID":32211,"compounds":"(Z)-5-oxohex-2-enedioate = (2E,4Z)-2-hydroxyhexa-2,4-dienedioate"}
{"X":34125,"RHEA_ID":42182,"compounds":"(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + A + 2 H2O => (6Z,9Z,12Z)-octadecatrienoyl-CoA + AH2 + O2"}
{"X":34126,"RHEA_ID":42183,"compounds":"(6Z,9Z,12Z)-octadecatrienoyl-CoA + AH2 + O2 <=> (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + A + 2 H2O"}
{"X":34127,"RHEA_ID":42184,"compounds":"5alpha-androstane-3beta,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH"}
{"X":34128,"RHEA_ID":32215,"DIRECTION":"UN","MASTER_ID":32215,"ec":"5.1.99.6","compounds":"(6R)-NADHX = (6S)-NADHX"}
{"X":34129,"RHEA_ID":42186,"compounds":"17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH => 5alpha-androstane-3beta,17beta-diol + NAD(+)"}
{"X":34130,"RHEA_ID":42187,"compounds":"5alpha-androstane-3beta,17beta-diol + NAD(+) <=> 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH"}
{"X":34131,"RHEA_ID":42188,"compounds":"3beta-hydroxy-5alpha-androstan-17-one + NAD(+) = 5alpha-androstan-3,17-dione + H(+) + NADH"}
{"X":34132,"RHEA_ID":32219,"DIRECTION":"UN","MASTER_ID":32219,"ec":"5.5.1.19","compounds":"all-trans-lycopene = gamma-carotene"}
{"X":34133,"RHEA_ID":42190,"compounds":"5alpha-androstan-3,17-dione + H(+) + NADH => 3beta-hydroxy-5alpha-androstan-17-one + NAD(+)"}
{"X":34134,"RHEA_ID":42191,"compounds":"3beta-hydroxy-5alpha-androstan-17-one + NAD(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADH"}
{"X":34135,"RHEA_ID":42192,"compounds":"(9Z)-pentadecenoyl-CoA + AH2 + O2 = (9Z,12Z)-pentadecadienoyl-CoA + A + 2 H2O"}
{"X":34136,"RHEA_ID":32223,"DIRECTION":"UN","MASTER_ID":32223,"ec":"4.2.1.136","compounds":"(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate"}
{"X":34137,"RHEA_ID":32224,"DIRECTION":"LR","MASTER_ID":32223,"ecocyc":"RXN0-6727","metacyc":"RXN0-6727","compounds":"(6S)-NADHX + ADP => AMP + H(+) + NADH + phosphate"}
{"X":34138,"RHEA_ID":42195,"compounds":"(9Z)-pentadecenoyl-CoA + AH2 + O2 <=> (9Z,12Z)-pentadecadienoyl-CoA + A + 2 H2O"}
{"X":34139,"RHEA_ID":42196,"compounds":"(9Z)-heptadecenoyl-CoA + AH2 + O2 = (9Z,12Z)-heptadecadienoyl-CoA + A + 2 H2O"}
{"X":34140,"RHEA_ID":32227,"DIRECTION":"UN","MASTER_ID":32227,"ec":"5.1.99.6","compounds":"(6R)-NADPHX = (6S)-NADPHX"}
{"X":34141,"RHEA_ID":42198,"compounds":"(9Z,12Z)-heptadecadienoyl-CoA + A + 2 H2O => (9Z)-heptadecenoyl-CoA + AH2 + O2"}
{"X":34142,"RHEA_ID":42199,"compounds":"(9Z)-heptadecenoyl-CoA + AH2 + O2 <=> (9Z,12Z)-heptadecadienoyl-CoA + A + 2 H2O"}
{"X":34143,"RHEA_ID":42200,"compounds":"corticosterone + NADP(+) = 11-dehydrocorticosterone + H(+) + NADPH"}
{"X":34144,"RHEA_ID":32231,"DIRECTION":"UN","MASTER_ID":32231,"ec":"4.2.1.93","compounds":"(6S)-NADPHX + ATP = ADP + H(+) + NADPH + phosphate"}
{"X":34145,"RHEA_ID":42202,"compounds":"11-dehydrocorticosterone + H(+) + NADPH => corticosterone + NADP(+)"}
{"X":34146,"RHEA_ID":42203,"compounds":"corticosterone + NADP(+) <=> 11-dehydrocorticosterone + H(+) + NADPH"}
{"X":34147,"RHEA_ID":42204,"compounds":"corticosterone + NAD(+) = 11-dehydrocorticosterone + H(+) + NADH"}
{"X":34148,"RHEA_ID":32235,"DIRECTION":"UN","MASTER_ID":32235,"ec":"4.2.1.136","compounds":"(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate"}
{"X":34149,"RHEA_ID":42206,"compounds":"11-dehydrocorticosterone + H(+) + NADH => corticosterone + NAD(+)"}
{"X":34150,"RHEA_ID":42207,"compounds":"corticosterone + NAD(+) <=> 11-dehydrocorticosterone + H(+) + NADH"}
{"X":34151,"RHEA_ID":42208,"DIRECTION":"UN","MASTER_ID":42208,"ec":"1.14.13.237","compounds":"an omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + H(+) + NADPH + O2 = an omega-(methylsulfinyl)-alkyl-glucosinolate + H2O + NADP(+)"}
{"X":34152,"RHEA_ID":32239,"DIRECTION":"UN","MASTER_ID":32239,"ec":"5.5.1.19","compounds":"gamma-carotene = all-trans-beta-carotene"}
{"X":34153,"RHEA_ID":32240,"DIRECTION":"LR","MASTER_ID":32239,"metacyc":"RXN1F-151","compounds":"gamma-carotene => all-trans-beta-carotene"}
{"X":34154,"RHEA_ID":42212,"DIRECTION":"UN","MASTER_ID":42212,"ec":"3.1.1.111","compounds":"1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O = a 2-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)"}
{"X":34155,"RHEA_ID":32243,"DIRECTION":"UN","MASTER_ID":32243,"ec":"5.3.1.29","compounds":"alpha-D-ribose 1,5-bisphosphate = D-ribulose 1,5-bisphosphate"}
{"X":34156,"RHEA_ID":42214,"compounds":"a 2-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+) => 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O"}
{"X":34157,"RHEA_ID":42215,"compounds":"1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O <=> a 2-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)"}
{"X":34158,"RHEA_ID":42216,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) = 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-1D-myo-inositol + CoA"}
{"X":34159,"RHEA_ID":32247,"DIRECTION":"UN","MASTER_ID":32247,"ec":"1.5.1.34","compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) = (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADPH"}
{"X":34160,"RHEA_ID":42218,"compounds":"1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-1D-myo-inositol + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)"}
{"X":34161,"RHEA_ID":32249,"DIRECTION":"RL","MASTER_ID":32247,"metacyc":"RXN-14245","compounds":"(6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADPH => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+)"}
{"X":34162,"RHEA_ID":42220,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate = 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA"}
{"X":34163,"RHEA_ID":32251,"DIRECTION":"UN","MASTER_ID":32251,"ec":"1.5.1.34","compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD(+) = (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADH"}
{"X":34164,"RHEA_ID":42222,"compounds":"1-heptadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate"}
{"X":34165,"RHEA_ID":42223,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate <=> 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA"}
{"X":34166,"RHEA_ID":32253,"DIRECTION":"RL","MASTER_ID":32251,"metacyc":"RXN-7909","compounds":"(6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADH => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD(+)"}
{"X":34167,"RHEA_ID":42225,"compounds":"A + testosterone => AH2 + androst-4-ene-3,17-dione"}
{"X":34168,"RHEA_ID":42226,"compounds":"AH2 + androst-4-ene-3,17-dione => A + testosterone"}
{"X":34169,"RHEA_ID":42227,"compounds":"A + testosterone <=> AH2 + androst-4-ene-3,17-dione"}
{"X":34170,"RHEA_ID":32257,"compounds":"(S)-2,3,4,5-tetrahydrodipicolinate + 2 H(+) + NADPH + NH4(+) => meso-2,6-diaminoheptanedioate + NADP(+)"}
{"X":34171,"RHEA_ID":32258,"compounds":"meso-2,6-diaminoheptanedioate + NADP(+) <=> (S)-2,3,4,5-tetrahydrodipicolinate + 2 H(+) + NADPH + NH4(+)"}
{"X":34172,"RHEA_ID":42230,"compounds":"AH2 + estrone => 17beta-estradiol + A"}
{"X":34173,"RHEA_ID":42231,"compounds":"17beta-estradiol + A <=> AH2 + estrone"}
{"X":34174,"RHEA_ID":32261,"compounds":"1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde => beta-D-fructose 1-phosphate + methylglyoxal"}
{"X":34175,"RHEA_ID":42233,"compounds":"(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(9Z)-octadecenoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":34176,"RHEA_ID":42234,"compounds":"1-(9Z)-octadecenoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":34177,"RHEA_ID":42235,"compounds":"(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(9Z)-octadecenoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":34178,"RHEA_ID":32265,"compounds":"L-alanine + succinate semialdehyde => 4-aminobutanoate + pyruvate"}
{"X":34179,"RHEA_ID":42237,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":34180,"RHEA_ID":42238,"compounds":"1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA"}
{"X":34181,"RHEA_ID":32268,"compounds":"4-aminobutanoate + glyoxylate => glycine + succinate semialdehyde"}
{"X":34182,"RHEA_ID":32269,"compounds":"glycine + succinate semialdehyde => 4-aminobutanoate + glyoxylate"}
{"X":34183,"RHEA_ID":42241,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + tetradecanoyl-CoA => 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":34184,"RHEA_ID":42242,"compounds":"1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + tetradecanoyl-CoA"}
{"X":34185,"RHEA_ID":42243,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + tetradecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":34186,"RHEA_ID":32273,"compounds":"4-methyl-2-oxopentanoate + CO2 + NADH => (2R,3S)-3-isopropylmalate + NAD(+)"}
{"X":34187,"RHEA_ID":42245,"compounds":"H(+) + malonyl-[ACP] + propanoyl-CoA => 3-oxopentanoyl-[ACP] + CO2 + CoA"}
{"X":34188,"RHEA_ID":32275,"DIRECTION":"UN","MASTER_ID":32275,"ec":"1.1.1.262","compounds":"4-(phosphooxy)-L-threonine + NAD(+) = 3-amino-2-oxopropyl phosphate + CO2 + NADH"}
{"X":34189,"RHEA_ID":32276,"DIRECTION":"LR","MASTER_ID":32275,"ecocyc":"RXN-13179","metacyc":"RXN-13179","compounds":"4-(phosphooxy)-L-threonine + NAD(+) => 3-amino-2-oxopropyl phosphate + CO2 + NADH"}
{"X":34190,"RHEA_ID":32277,"compounds":"3-amino-2-oxopropyl phosphate + CO2 + NADH => 4-(phosphooxy)-L-threonine + NAD(+)"}
{"X":34191,"RHEA_ID":42249,"DIRECTION":"LR","MASTER_ID":42248,"metacyc":"RXN-9648","compounds":"butanoyl-CoA + H(+) + malonyl-[ACP] => 3-oxohexanoyl-[ACP] + CO2 + CoA"}
{"X":34192,"RHEA_ID":42250,"compounds":"3-oxohexanoyl-[ACP] + CO2 + CoA => butanoyl-CoA + H(+) + malonyl-[ACP]"}
{"X":34193,"RHEA_ID":32281,"compounds":"(S)-ureidoglycolate + CO2 + 2 NH4(+) => allantoate + 2 H(+) + 2 H2O"}
{"X":34194,"RHEA_ID":32282,"compounds":"allantoate + 2 H(+) + 2 H2O <=> (S)-ureidoglycolate + CO2 + 2 NH4(+)"}
{"X":34195,"RHEA_ID":42254,"compounds":"3-oxoheptanoyl-[ACP] + CO2 + CoA => H(+) + malonyl-[ACP] + pentanoyl-CoA"}
{"X":34196,"RHEA_ID":32284,"compounds":"3-hydroxyanthranilate + O2 => H(+) + H2O + quinolinate"}
{"X":34197,"RHEA_ID":32285,"compounds":"H(+) + H2O + quinolinate => 3-hydroxyanthranilate + O2"}
{"X":34198,"RHEA_ID":32286,"compounds":"3-hydroxyanthranilate + O2 <=> H(+) + H2O + quinolinate"}
{"X":34199,"RHEA_ID":42258,"compounds":"3-oxooctanoyl-[ACP] + CO2 + CoA => H(+) + hexanoyl-CoA + malonyl-[ACP]"}
{"X":34200,"RHEA_ID":42259,"compounds":"H(+) + hexanoyl-CoA + malonyl-[ACP] <=> 3-oxooctanoyl-[ACP] + CO2 + CoA"}
{"X":34201,"RHEA_ID":32289,"compounds":"(2S)-2-isopropylmalate => (2R,3S)-3-isopropylmalate"}
{"X":34202,"RHEA_ID":42261,"compounds":"H(+) + heptanoyl-CoA + malonyl-[ACP] => 3-oxononanoyl-[ACP] + CO2 + CoA"}
{"X":34203,"RHEA_ID":42262,"compounds":"3-oxononanoyl-[ACP] + CO2 + CoA => H(+) + heptanoyl-CoA + malonyl-[ACP]"}
{"X":34204,"RHEA_ID":42263,"compounds":"H(+) + heptanoyl-CoA + malonyl-[ACP] <=> 3-oxononanoyl-[ACP] + CO2 + CoA"}
{"X":34205,"RHEA_ID":32293,"compounds":"3 H(+) + phosphocholine + 3 S-adenosyl-L-homocysteine => phosphoethanolamine + 3 S-adenosyl-L-methionine"}
{"X":34206,"RHEA_ID":32294,"compounds":"phosphoethanolamine + 3 S-adenosyl-L-methionine <=> 3 H(+) + phosphocholine + 3 S-adenosyl-L-homocysteine"}
{"X":34207,"RHEA_ID":42266,"compounds":"3-oxodecanoyl-[ACP] + CO2 + CoA => H(+) + malonyl-[ACP] + octanoyl-CoA"}
{"X":34208,"RHEA_ID":52240,"DIRECTION":"UN","MASTER_ID":52240,"ec":"1.16.3.3","compounds":"2 H2O + 2 Mn(2+) + O2 = 4 H(+) + 2 MnO2"}
{"X":34209,"RHEA_ID":32297,"compounds":"2 diphosphate + NADP(+) + squalene => 2 (2E,6E)-farnesyl diphosphate + H(+) + NADPH"}
{"X":34210,"RHEA_ID":42269,"compounds":"2-methylpropanoyl-CoA + H(+) + malonyl-[ACP] => 3-oxo-4-methylpentanoyl-[ACP] + CO2 + CoA"}
{"X":34211,"RHEA_ID":32299,"DIRECTION":"UN","MASTER_ID":32299,"ec":"2.5.1.21","compounds":"2 (2E,6E)-farnesyl diphosphate + H(+) + NADH = 2 diphosphate + NAD(+) + squalene"}
{"X":34212,"RHEA_ID":32300,"DIRECTION":"LR","MASTER_ID":32299,"metacyc":"RXN-13162","compounds":"2 (2E,6E)-farnesyl diphosphate + H(+) + NADH => 2 diphosphate + NAD(+) + squalene"}
{"X":34213,"RHEA_ID":32301,"compounds":"2 diphosphate + NAD(+) + squalene => 2 (2E,6E)-farnesyl diphosphate + H(+) + NADH"}
{"X":34214,"RHEA_ID":32302,"compounds":"2 (2E,6E)-farnesyl diphosphate + H(+) + NADH <=> 2 diphosphate + NAD(+) + squalene"}
{"X":34215,"RHEA_ID":32303,"DIRECTION":"UN","MASTER_ID":32303,"ec":"4.2.1.114","compounds":"(2R)-homocitrate = (1R,2S)-homoisocitrate"}
{"X":34216,"RHEA_ID":42275,"compounds":"3-methylbutanoyl-CoA + H(+) + malonyl-[ACP] <=> 3-oxo-5-methylhexanoyl-[ACP] + CO2 + CoA"}
{"X":34217,"RHEA_ID":32305,"compounds":"(1R,2S)-homoisocitrate => (2R)-homocitrate"}
{"X":34218,"RHEA_ID":42277,"compounds":"2-methylbutanoyl-CoA + H(+) + malonyl-[ACP] => 3-oxo-4-methylhexanoyl-[ACP] + CO2 + CoA"}
{"X":34219,"RHEA_ID":32307,"DIRECTION":"UN","MASTER_ID":32307,"ec":"1.13.11.34","compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = H2O + leukotriene A4"}
{"X":34220,"RHEA_ID":52252,"DIRECTION":"UN","MASTER_ID":52252,"ec":"1.17.98.2","compounds":"a bacteriochlorophyllide c + H2O + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + a bacteriochlorophyllide e + 2 H(+) + 2 L-methionine"}
{"X":34221,"RHEA_ID":32309,"compounds":"H2O + leukotriene A4 => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2"}
{"X":34222,"RHEA_ID":42281,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (5Z,8Z,11R,12E,14Z)-11-hydroperoxyeicosatetraenoate"}
{"X":34223,"RHEA_ID":32311,"DIRECTION":"UN","MASTER_ID":32311,"ec":"1.14.14.36","compounds":"L-tyrosine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-4-hydroxyphenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":34224,"RHEA_ID":42283,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (5Z,8Z,11R,12E,14Z)-11-hydroperoxyeicosatetraenoate"}
{"X":34225,"RHEA_ID":32313,"compounds":"(E)-4-hydroxyphenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-tyrosine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}
{"X":34226,"RHEA_ID":52258,"compounds":"5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide c + H(+) + L-methionine => a 7(1)-hydroxybacteriochlorophyllide c + H2O + S-adenosyl-L-methionine"}
{"X":34227,"RHEA_ID":32323,"DIRECTION":"UN","MASTER_ID":32323,"ec":"1.14.14.86","compounds":"ent-kaur-16-ene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = ent-kaur-16-en-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}
{"X":34228,"RHEA_ID":42287,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate"}
{"X":34229,"RHEA_ID":32325,"compounds":"ent-kaur-16-en-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => ent-kaur-16-ene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]"}
{"X":34230,"RHEA_ID":52262,"compounds":"a bacteriochlorophyllide e + H2O => a 7(1),7(1)-dihydroxybacteriochlorophyllide c"}
{"X":34231,"RHEA_ID":32327,"DIRECTION":"UN","MASTER_ID":32327,"ec":"1.1.1.326","compounds":"10-hydroxy-alpha-humulene + NAD(+) = H(+) + NADH + zerumbone"}
{"X":34232,"RHEA_ID":32328,"DIRECTION":"LR","MASTER_ID":32327,"metacyc":"RXN-10629","compounds":"10-hydroxy-alpha-humulene + NAD(+) => H(+) + NADH + zerumbone"}
{"X":34233,"RHEA_ID":32329,"compounds":"H(+) + NADH + zerumbone => 10-hydroxy-alpha-humulene + NAD(+)"}
{"X":34234,"RHEA_ID":42293,"compounds":"a fatty acyl-[ACP] + phosphate => an acyl phosphate + holo-[ACP]"}
{"X":34235,"RHEA_ID":32331,"DIRECTION":"UN","MASTER_ID":32331,"ec":"1.1.1.322","metacyc":"RXN-12955","compounds":"(1S,2S,4R)-endo-fenchol + NAD(+) = (1S,4R)-fenchone + H(+) + NADH"}
{"X":34236,"RHEA_ID":42295,"DIRECTION":"BI","MASTER_ID":42292,"ecocyc":"RXN-9590","metacyc":"RXN-9590","compounds":"a fatty acyl-[ACP] + phosphate <=> an acyl phosphate + holo-[ACP]"}
{"X":34237,"RHEA_ID":32333,"compounds":"(1S,4R)-fenchone + H(+) + NADH => (1S,2S,4R)-endo-fenchol + NAD(+)"}
{"X":34238,"RHEA_ID":52270,"compounds":"(1H-indol-3-yl)-N-methylmethanamine + H(+) + S-adenosyl-L-homocysteine => 3-(aminomethyl)indole + S-adenosyl-L-methionine"}
{"X":34239,"RHEA_ID":32335,"DIRECTION":"UN","MASTER_ID":32335,"ec":"1.1.1.322","metacyc":"RXN-12955","compounds":"(1S,2S,4R)-endo-fenchol + NADP(+) = (1S,4R)-fenchone + H(+) + NADPH"}
{"X":34240,"RHEA_ID":32336,"compounds":"(1S,2S,4R)-endo-fenchol + NADP(+) => (1S,4R)-fenchone + H(+) + NADPH"}
{"X":34241,"RHEA_ID":32337,"compounds":"(1S,4R)-fenchone + H(+) + NADPH => (1S,2S,4R)-endo-fenchol + NADP(+)"}
{"X":34242,"RHEA_ID":52274,"compounds":"gramine + H(+) + S-adenosyl-L-homocysteine => (1H-indol-3-yl)-N-methylmethanamine + S-adenosyl-L-methionine"}
{"X":34243,"RHEA_ID":32339,"DIRECTION":"UN","MASTER_ID":32339,"ec":"1.1.1.323","compounds":"(+)-thujan-3-ol + NADP(+) = (+)-thujan-3-one + H(+) + NADPH"}
{"X":34244,"RHEA_ID":32341,"compounds":"(+)-thujan-3-one + H(+) + NADPH => (+)-thujan-3-ol + NADP(+)"}
{"X":34245,"RHEA_ID":52278,"compounds":"(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4-dihydroxybenzoate => (6S)-5,6,7,8-tetrahydrofolate + 4-hydroxy-3-methoxybenzoate"}
{"X":34246,"RHEA_ID":32343,"DIRECTION":"UN","MASTER_ID":32343,"ec":"1.1.1.323","compounds":"(+)-thujan-3-ol + NAD(+) = (+)-thujan-3-one + H(+) + NADH"}
{"X":34247,"RHEA_ID":42307,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol-3'-phosphate) + H2O <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate"}
{"X":34248,"RHEA_ID":32345,"compounds":"(+)-thujan-3-one + H(+) + NADH => (+)-thujan-3-ol + NAD(+)"}
{"X":34249,"RHEA_ID":52282,"compounds":"(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4,5-trihydroxybenzoate => (6S)-5,6,7,8-tetrahydrofolate + 3-O-methylgallate"}
{"X":34250,"RHEA_ID":32347,"DIRECTION":"UN","MASTER_ID":32347,"ec":"2.1.1.175","compounds":"2 S-adenosyl-L-methionine + tricetin = 3',5'-di-O-methyltricetin + 2 H(+) + 2 S-adenosyl-L-homocysteine"}
{"X":34251,"RHEA_ID":42311,"compounds":"1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}
{"X":34252,"RHEA_ID":32349,"compounds":"3',5'-di-O-methyltricetin + 2 H(+) + 2 S-adenosyl-L-homocysteine => 2 S-adenosyl-L-methionine + tricetin"}
{"X":34253,"RHEA_ID":42313,"compounds":"H(+) + NADP(+) + 2 reduced [adrenodoxin] => NADPH + 2 oxidized [adrenodoxin]"}
{"X":34254,"RHEA_ID":32351,"DIRECTION":"UN","MASTER_ID":32351,"ec":"2.1.1.169","compounds":"3 S-adenosyl-L-methionine + tricetin = 3',4',5'-O-trimethyltricetin + 3 H(+) + 3 S-adenosyl-L-homocysteine"}
{"X":34255,"RHEA_ID":32353,"compounds":"3',4',5'-O-trimethyltricetin + 3 H(+) + 3 S-adenosyl-L-homocysteine => 3 S-adenosyl-L-methionine + tricetin"}
{"X":34256,"RHEA_ID":42317,"DIRECTION":"LR","MASTER_ID":42316,"metacyc":"RXN-14474","compounds":"a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] => an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":34257,"RHEA_ID":32355,"DIRECTION":"UN","MASTER_ID":32355,"ec":"2.4.1.249","compounds":"delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + 2 UDP-alpha-D-glucose = 2 H(+) + ternatin C5 + 2 UDP"}
{"X":34258,"RHEA_ID":32357,"compounds":"2 H(+) + ternatin C5 + 2 UDP => delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + 2 UDP-alpha-D-glucose"}
{"X":34259,"RHEA_ID":42321,"compounds":"a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O => a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}
{"X":34260,"RHEA_ID":42322,"compounds":"a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O"}
{"X":34261,"RHEA_ID":32360,"compounds":"1D-myo-inositol 1,4,5-trisphosphate + 2 ATP => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+)"}
{"X":34262,"RHEA_ID":32361,"compounds":"1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+) => 1D-myo-inositol 1,4,5-trisphosphate + 2 ATP"}
{"X":34263,"RHEA_ID":42325,"compounds":"2 oxidized [2Fe-2S]-[ferredoxin] + reduced coenzyme F420-(gamma-Glu)(n) => 3 H(+) + oxidized coenzyme F420-(gamma-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":34264,"RHEA_ID":42326,"compounds":"3 H(+) + oxidized coenzyme F420-(gamma-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin] => 2 oxidized [2Fe-2S]-[ferredoxin] + reduced coenzyme F420-(gamma-Glu)(n)"}
{"X":34265,"RHEA_ID":52300,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":34266,"RHEA_ID":32365,"compounds":"H(+) + H2O2 + L-ascorbate => L-gulono-1,4-lactone + O2"}
{"X":34267,"RHEA_ID":42329,"compounds":"1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-3-phosphate) + H2O => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}
{"X":34268,"RHEA_ID":32367,"DIRECTION":"UN","MASTER_ID":32367,"ec":"1.3.2.3","compounds":"4 [Fe(III)cytochrome c] + L-galactono-1,4-lactone = 4 [Fe(II)cytochrome c] + 5 H(+) + L-dehydroascorbate"}
{"X":34269,"RHEA_ID":42331,"compounds":"1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-3-phosphate) + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}
{"X":34270,"RHEA_ID":32369,"compounds":"4 [Fe(II)cytochrome c] + 5 H(+) + L-dehydroascorbate => 4 [Fe(III)cytochrome c] + L-galactono-1,4-lactone"}
{"X":34271,"RHEA_ID":42333,"DIRECTION":"LR","MASTER_ID":42332,"metacyc":"RXN-8087","compounds":"ATP + L-glutamate + oxidized coenzyme F420-2 => ADP + H(+) + oxidized coenzyme alpha-F420-3 + phosphate"}
{"X":34272,"RHEA_ID":42334,"compounds":"ADP + H(+) + oxidized coenzyme alpha-F420-3 + phosphate => ATP + L-glutamate + oxidized coenzyme F420-2"}
{"X":34273,"RHEA_ID":52308,"compounds":"2-hydroxyglutarate + NADP(+) = 2-oxoglutarate + H(+) + NADPH"}
{"X":34274,"RHEA_ID":32373,"compounds":"all-trans-zeaxanthin + 2 H2O + 2 L-dehydroascorbate => all-trans-violaxanthin + 2 L-ascorbate"}
{"X":34275,"RHEA_ID":42337,"compounds":"[thioredoxin]-disulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => [thioredoxin]-dithiol + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":34276,"RHEA_ID":42338,"compounds":"[thioredoxin]-dithiol + 2 oxidized [2Fe-2S]-[ferredoxin] => [thioredoxin]-disulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":34277,"RHEA_ID":32376,"compounds":"limonene-1,2-diol + NAD(+) => 1-hydroxylimonen-2-one + H(+) + NADH"}
{"X":34278,"RHEA_ID":32377,"compounds":"1-hydroxylimonen-2-one + H(+) + NADH => limonene-1,2-diol + NAD(+)"}
{"X":34279,"RHEA_ID":32378,"compounds":"limonene-1,2-diol + NAD(+) <=> 1-hydroxylimonen-2-one + H(+) + NADH"}
{"X":34280,"RHEA_ID":42342,"compounds":"4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADH => 4-(gamma-L-glutamylamino)butanal + H2O + NAD(+)"}
{"X":34281,"RHEA_ID":32380,"compounds":"(1R,2R,4S)-limonene-1,2-diol + NAD(+) => (1R,4S)-1-hydroxylimonen-2-one + H(+) + NADH"}
{"X":34282,"RHEA_ID":32381,"compounds":"(1R,4S)-1-hydroxylimonen-2-one + H(+) + NADH => (1R,2R,4S)-limonene-1,2-diol + NAD(+)"}
{"X":34283,"RHEA_ID":42345,"DIRECTION":"LR","MASTER_ID":42344,"metacyc":"RXN-664","compounds":"H(+) + NADH + O2 + p-cumate => (2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+)"}
{"X":34284,"RHEA_ID":42346,"compounds":"(2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+) => H(+) + NADH + O2 + p-cumate"}
{"X":34285,"RHEA_ID":52320,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + tryptamine = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + serotonin"}
{"X":34286,"RHEA_ID":32385,"compounds":"(1S,4R)-1-hydroxylimonen-2-one + H(+) + NADH => (1S,2S,4R)-limonene-1,2-diol + NAD(+)"}
{"X":34287,"RHEA_ID":42349,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + ADP + H(+)"}
{"X":34288,"RHEA_ID":42350,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + ADP + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP"}
{"X":34289,"RHEA_ID":42351,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + ADP + H(+)"}
{"X":34290,"RHEA_ID":32389,"compounds":"dihydrocarvone + H(+) + NADH => dihydrocarveol + NAD(+)"}
{"X":34291,"RHEA_ID":42353,"DIRECTION":"LR","MASTER_ID":42352,"metacyc":"R161-RXN","compounds":"(R)-nicotine + A + H2O => (R)-6-hydroxynicotine + AH2"}
{"X":34292,"RHEA_ID":45650,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+)"}
{"X":34293,"RHEA_ID":52328,"compounds":"L-arginine + O2 + reduced [flavodoxin] = H(+) + H2O + N(omega)-hydroxy-L-arginine + oxidized [flavodoxin]"}
{"X":34294,"RHEA_ID":32392,"DIRECTION":"LR","MASTER_ID":32391,"metacyc":"RXN-9424","compounds":"(1R,2R,4R)-dihydrocarveol + NAD(+) => (1R,4R)-dihydrocarvone + H(+) + NADH"}
{"X":34295,"RHEA_ID":32393,"compounds":"(1R,4R)-dihydrocarvone + H(+) + NADH => (1R,2R,4R)-dihydrocarveol + NAD(+)"}
{"X":34296,"RHEA_ID":32394,"compounds":"(1R,2R,4R)-dihydrocarveol + NAD(+) <=> (1R,4R)-dihydrocarvone + H(+) + NADH"}
{"X":34297,"RHEA_ID":42359,"compounds":"(9Z)-tetradecenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(11Z)-hexadecenoyl-CoA + CO2 + CoA"}
{"X":34298,"RHEA_ID":32396,"DIRECTION":"LR","MASTER_ID":32395,"metacyc":"RXN-9429","compounds":"(1S,2S,4S)-dihydrocarveol + NAD(+) => (1S,4S)-dihydrocarvone + H(+) + NADH"}
{"X":34299,"RHEA_ID":32397,"compounds":"(1S,4S)-dihydrocarvone + H(+) + NADH => (1S,2S,4S)-dihydrocarveol + NAD(+)"}
{"X":34300,"RHEA_ID":42361,"compounds":"D-allulose => keto-D-fructose"}
{"X":34301,"RHEA_ID":42362,"compounds":"keto-D-fructose => D-allulose"}
{"X":34302,"RHEA_ID":32400,"DIRECTION":"LR","MASTER_ID":32399,"metacyc":"RXN-9430","compounds":"(1S,2R,4S)-neodihydrocarveol + NAD(+) => (1S,4S)-dihydrocarvone + H(+) + NADH"}
{"X":34303,"RHEA_ID":32401,"compounds":"(1S,4S)-dihydrocarvone + H(+) + NADH => (1S,2R,4S)-neodihydrocarveol + NAD(+)"}
{"X":34304,"RHEA_ID":42365,"compounds":"2 a 2-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine"}
{"X":34305,"RHEA_ID":32403,"DIRECTION":"UN","MASTER_ID":32403,"ec":"1.1.1.296","compounds":"(1R,2S,4R)-neodihydrocarveol + NAD(+) = (1R,4R)-dihydrocarvone + H(+) + NADH"}
{"X":34306,"RHEA_ID":32404,"DIRECTION":"LR","MASTER_ID":32403,"metacyc":"RXN-9392","compounds":"(1R,2S,4R)-neodihydrocarveol + NAD(+) => (1R,4R)-dihydrocarvone + H(+) + NADH"}
{"X":34307,"RHEA_ID":32405,"compounds":"(1R,4R)-dihydrocarvone + H(+) + NADH => (1R,2S,4R)-neodihydrocarveol + NAD(+)"}
{"X":34308,"RHEA_ID":42369,"DIRECTION":"LR","MASTER_ID":42368,"metacyc":"RXN-15673","compounds":"dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + monacolin L carboxylate + oxidized [NADPH--hemoprotein reductase]"}
{"X":34309,"RHEA_ID":42370,"compounds":"H(+) + 2 H2O + monacolin L carboxylate + oxidized [NADPH--hemoprotein reductase] => dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":34310,"RHEA_ID":32408,"DIRECTION":"LR","MASTER_ID":32407,"metacyc":"RXN-9425","compounds":"(1R,2S,4S)-neoisodihydrocarveol + NAD(+) => (1R,4S)-isodihydrocarvone + H(+) + NADH"}
{"X":34311,"RHEA_ID":32409,"compounds":"(1R,4S)-isodihydrocarvone + H(+) + NADH => (1R,2S,4S)-neoisodihydrocarveol + NAD(+)"}
{"X":34312,"RHEA_ID":42373,"DIRECTION":"LR","MASTER_ID":42372,"metacyc":"RXN-8200","compounds":"16-methoxytabersonine + H2O => (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine"}
{"X":34313,"RHEA_ID":32411,"DIRECTION":"UN","MASTER_ID":32411,"ec":"1.1.1.296","compounds":"(1R,2R,4S)-isodihydrocarveol + NAD(+) = (1R,4S)-isodihydrocarvone + H(+) + NADH"}
{"X":34314,"RHEA_ID":32412,"DIRECTION":"LR","MASTER_ID":32411,"metacyc":"RXN-9426","compounds":"(1R,2R,4S)-isodihydrocarveol + NAD(+) => (1R,4S)-isodihydrocarvone + H(+) + NADH"}
{"X":34315,"RHEA_ID":42376,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + phosphate"}
{"X":34316,"RHEA_ID":42377,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + phosphate"}
{"X":34317,"RHEA_ID":32415,"DIRECTION":"UN","MASTER_ID":32415,"ec":"1.1.1.296","compounds":"(1S,2S,4R)-isodihydrocarveol + NAD(+) = (1S,4R)-isodihydrocarvone + H(+) + NADH"}
{"X":34318,"RHEA_ID":32416,"DIRECTION":"LR","MASTER_ID":32415,"metacyc":"RXN-9433","compounds":"(1S,2S,4R)-isodihydrocarveol + NAD(+) => (1S,4R)-isodihydrocarvone + H(+) + NADH"}
{"X":34319,"RHEA_ID":32417,"compounds":"(1S,4R)-isodihydrocarvone + H(+) + NADH => (1S,2S,4R)-isodihydrocarveol + NAD(+)"}
{"X":34320,"RHEA_ID":42381,"DIRECTION":"LR","MASTER_ID":42380,"metacyc":"RXN-12225","compounds":"2 A + all-trans-4,4'-diapolycopene-4,4'-dial + 2 H2O => 2 AH2 + all-trans-4,4'-diapolycopene-4,4'-dioate + 2 H(+)"}
{"X":34321,"RHEA_ID":32419,"DIRECTION":"UN","MASTER_ID":32419,"ec":"1.1.1.296","compounds":"(1S,2R,4R)-neoisodihydrocarveol + NAD(+) = (1S,4R)-isodihydrocarvone + H(+) + NADH"}
{"X":34322,"RHEA_ID":32420,"DIRECTION":"LR","MASTER_ID":32419,"metacyc":"RXN-9434","compounds":"(1S,2R,4R)-neoisodihydrocarveol + NAD(+) => (1S,4R)-isodihydrocarvone + H(+) + NADH"}
{"X":34323,"RHEA_ID":42384,"compounds":"4,4'-diaponeurosporenal + H2O + NAD(+) = 4,4'-diaponeurosporenoate + 2 H(+) + NADH"}
{"X":34324,"RHEA_ID":32422,"compounds":"(1S,2R,4R)-neoisodihydrocarveol + NAD(+) <=> (1S,4R)-isodihydrocarvone + H(+) + NADH"}
{"X":34325,"RHEA_ID":32423,"DIRECTION":"UN","MASTER_ID":32423,"ec":"1.3.99.25","compounds":"(1R,4R)-dihydrocarvone + A = (R)-carvone + AH2"}
{"X":34326,"RHEA_ID":32424,"compounds":"(1R,4R)-dihydrocarvone + A => (R)-carvone + AH2"}
{"X":34327,"RHEA_ID":42388,"DIRECTION":"UN","MASTER_ID":42388,"ec":"2.4.1.330","compounds":"beta-D-glucosyl crocetin + UDP-alpha-D-glucose = beta-D-gentiobiosyl crocetin + H(+) + UDP"}
{"X":34328,"RHEA_ID":52371,"compounds":"3'-phosphoadenylyl sulfate + cholesterol <=> adenosine 3',5'-bisphosphate + cholesterol sulfate + H(+)"}
{"X":34329,"RHEA_ID":32427,"DIRECTION":"UN","MASTER_ID":32427,"ec":"1.3.99.25","compounds":"(1R,4S)-isodihydrocarvone + A = (S)-carvone + AH2"}
{"X":34330,"RHEA_ID":32428,"compounds":"(1R,4S)-isodihydrocarvone + A => (S)-carvone + AH2"}
{"X":34331,"RHEA_ID":32429,"DIRECTION":"RL","MASTER_ID":32427,"metacyc":"RXN-9419","compounds":"(S)-carvone + AH2 => (1R,4S)-isodihydrocarvone + A"}
{"X":34332,"RHEA_ID":42393,"compounds":"D-galactose + NAD(+) => D-galactono-1,5-lactone + H(+) + NADH"}
{"X":34333,"RHEA_ID":32431,"DIRECTION":"UN","MASTER_ID":32431,"ec":"1.14.13.105","compounds":"(1R,4S)-menthone + H(+) + NADPH + O2 = (4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)"}
{"X":34334,"RHEA_ID":32432,"DIRECTION":"LR","MASTER_ID":32431,"metacyc":"RXN-9441","compounds":"(1R,4S)-menthone + H(+) + NADPH + O2 => (4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)"}
{"X":34335,"RHEA_ID":42396,"DIRECTION":"UN","MASTER_ID":42396,"ec":"2.1.1.205","compounds":"cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 H(+) + 2 S-adenosyl-L-homocysteine"}
{"X":34336,"RHEA_ID":45694,"compounds":"N-(octanoyl)-sphing-4-enine-1-phosphate(out) => N-(octanoyl)-sphing-4-enine-1-phosphate(in)"}
{"X":34337,"RHEA_ID":32435,"DIRECTION":"UN","MASTER_ID":32435,"ec":"1.14.13.105","compounds":"dihydrocarvone + H(+) + NADPH + O2 = 4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)"}
{"X":34338,"RHEA_ID":32436,"DIRECTION":"LR","MASTER_ID":32435,"metacyc":"RXN-9390","compounds":"dihydrocarvone + H(+) + NADPH + O2 => 4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)"}
{"X":34339,"RHEA_ID":42400,"DIRECTION":"UN","MASTER_ID":42400,"ec":"2.7.1.207","compounds":"lactose(out) + N(pros)-phospho-L-histidyl-[protein] = L-histidyl-[protein] + lactose 6-phosphate(in)"}
{"X":34340,"RHEA_ID":42401,"DIRECTION":"LR","MASTER_ID":42400,"metacyc":"RXN-15085","compounds":"lactose(out) + N(pros)-phospho-L-histidyl-[protein] => L-histidyl-[protein] + lactose 6-phosphate(in)"}
{"X":34341,"RHEA_ID":32439,"DIRECTION":"UN","MASTER_ID":32439,"ec":"1.14.13.106","compounds":"(+)-epi-isozizaene + 2 H(+) + 2 NADPH + 2 O2 = albaflavenone + 3 H2O + 2 NADP(+)"}
{"X":34342,"RHEA_ID":32440,"DIRECTION":"LR","MASTER_ID":32439,"metacyc":"RXN-13194","compounds":"(+)-epi-isozizaene + 2 H(+) + 2 NADPH + 2 O2 => albaflavenone + 3 H2O + 2 NADP(+)"}
{"X":34343,"RHEA_ID":42404,"DIRECTION":"UN","MASTER_ID":42404,"ec":"3.2.1.85","compounds":"H2O + lactose 6-phosphate = beta-D-glucose + D-galactose 6-phosphate"}
{"X":34344,"RHEA_ID":42405,"DIRECTION":"LR","MASTER_ID":42404,"metacyc":"LACTOSE6P-HYDROXY-RXN","compounds":"H2O + lactose 6-phosphate => beta-D-glucose + D-galactose 6-phosphate"}
{"X":34345,"RHEA_ID":32443,"DIRECTION":"UN","MASTER_ID":32443,"ec":"1.14.15.21","compounds":"all-trans-zeaxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = all-trans-violaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":34346,"RHEA_ID":32444,"DIRECTION":"LR","MASTER_ID":32443,"metacyc":"RXN-13193","compounds":"all-trans-zeaxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => all-trans-violaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":34347,"RHEA_ID":42408,"DIRECTION":"UN","MASTER_ID":42408,"ec":"2.7.2.16","compounds":"(2R)-2-phosphoglycerate + ATP = (2R)-2,3-bisphosphoglycerate + ADP + H(+)"}
{"X":34348,"RHEA_ID":42409,"compounds":"(2R)-2-phosphoglycerate + ATP => (2R)-2,3-bisphosphoglycerate + ADP + H(+)"}
{"X":34349,"RHEA_ID":32451,"compounds":"2 all-trans-geranylgeranyl diphosphate = all-trans-phytoene + 2 diphosphate"}
{"X":34350,"RHEA_ID":32452,"DIRECTION":"LR","MASTER_ID":32451,"metacyc":"RXN1F-144","compounds":"2 all-trans-geranylgeranyl diphosphate => all-trans-phytoene + 2 diphosphate"}
{"X":34351,"RHEA_ID":42412,"compounds":"(2R)-2,3-bisphosphoglycerate + ATP + H(+) = ADP + cyclic (2R)-2,3-bisphosphoglycerate + phosphate"}
{"X":34352,"RHEA_ID":45710,"compounds":"3-dehydrocarnityl-CoA + acetate => 3-dehydrocarnitine + acetyl-CoA"}
{"X":34353,"RHEA_ID":32455,"DIRECTION":"UN","MASTER_ID":32455,"ec":"1.14.14.151","compounds":"(-)-vetispiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + solavetivone"}
{"X":34354,"RHEA_ID":32456,"DIRECTION":"LR","MASTER_ID":32455,"metacyc":"RXN-13397","compounds":"(-)-vetispiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + solavetivone"}
{"X":34355,"RHEA_ID":32457,"compounds":"2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + solavetivone => (-)-vetispiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}
{"X":34356,"RHEA_ID":42417,"compounds":"a ubiquinone + L-proline => (S)-1-pyrroline-5-carboxylate + a ubiquinol + H(+)"}
{"X":34357,"RHEA_ID":32459,"DIRECTION":"UN","MASTER_ID":32459,"ec":"2.1.1.107","compounds":"2 S-adenosyl-L-methionine + uroporphyrinogen III = H(+) + precorrin-2 + 2 S-adenosyl-L-homocysteine"}
{"X":34358,"RHEA_ID":32460,"DIRECTION":"LR","MASTER_ID":32459,"ecocyc":"RXN-13403","metacyc":"RXN-13403","compounds":"2 S-adenosyl-L-methionine + uroporphyrinogen III => H(+) + precorrin-2 + 2 S-adenosyl-L-homocysteine"}
{"X":34359,"RHEA_ID":42420,"compounds":"2-oxoglutarate + L-lysine + O2 = (4R)-4-hydroxy-L-lysine + CO2 + succinate"}
{"X":34360,"RHEA_ID":52403,"compounds":"4-O-phospho-D-threonate + NAD(+) <=> 3-dehydro-4-O-phospho-L-erythronate + H(+) + NADH"}
{"X":34361,"RHEA_ID":32463,"DIRECTION":"UN","MASTER_ID":32463,"ec":"2.1.1.156","compounds":"glycine + 2 S-adenosyl-L-methionine = 2 H(+) + N,N-dimethylglycine + 2 S-adenosyl-L-homocysteine"}
{"X":34362,"RHEA_ID":32464,"DIRECTION":"LR","MASTER_ID":32463,"metacyc":"RXN-13404","compounds":"glycine + 2 S-adenosyl-L-methionine => 2 H(+) + N,N-dimethylglycine + 2 S-adenosyl-L-homocysteine"}
{"X":34363,"RHEA_ID":42424,"DIRECTION":"UN","MASTER_ID":42424,"ec":"4.2.1.35","compounds":"2-methylmaleate + H2O = (2R,3S)-3-methylmalate"}
{"X":34364,"RHEA_ID":35797,"compounds":"H(+) + kanamycin A + UDP => 2'-deamino-2'-hydroxyneamine + UDP-alpha-D-kanosamine"}
{"X":34365,"RHEA_ID":32467,"DIRECTION":"UN","MASTER_ID":32467,"ec":"2.1.1.157","compounds":"2 S-adenosyl-L-methionine + sarcosine = betaine + 2 H(+) + 2 S-adenosyl-L-homocysteine"}
{"X":34366,"RHEA_ID":32468,"DIRECTION":"LR","MASTER_ID":32467,"metacyc":"RXN-13405","compounds":"2 S-adenosyl-L-methionine + sarcosine => betaine + 2 H(+) + 2 S-adenosyl-L-homocysteine"}
{"X":34367,"RHEA_ID":42428,"compounds":"clavaminate = (3R,5R)-clavulanate-9-aldehyde"}
{"X":34368,"RHEA_ID":42429,"DIRECTION":"LR","MASTER_ID":42428,"metacyc":"RXN-8892","compounds":"clavaminate => (3R,5R)-clavulanate-9-aldehyde"}
{"X":34369,"RHEA_ID":32471,"DIRECTION":"UN","MASTER_ID":32471,"ec":"1.14.14.66","compounds":"demethylsuberosin + O2 + reduced [NADPH--hemoprotein reductase] = (7S)-marmesin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":34370,"RHEA_ID":32472,"DIRECTION":"LR","MASTER_ID":32471,"metacyc":"RXN-8383","compounds":"demethylsuberosin + O2 + reduced [NADPH--hemoprotein reductase] => (7S)-marmesin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":34371,"RHEA_ID":32473,"compounds":"(7S)-marmesin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => demethylsuberosin + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":34372,"RHEA_ID":42433,"DIRECTION":"LR","MASTER_ID":42432,"metacyc":"RXN-9922","compounds":"3-hydroxy-cis,cis-muconate => maleylacetate"}
{"X":34373,"RHEA_ID":32475,"DIRECTION":"UN","MASTER_ID":32475,"ec":"2.1.1.162","compounds":"glycine + 3 S-adenosyl-L-methionine = betaine + 3 H(+) + 3 S-adenosyl-L-homocysteine"}
{"X":34374,"RHEA_ID":52417,"DIRECTION":"LR","MASTER_ID":52416,"metacyc":"RXN-18589","compounds":"3-dehydro-4-O-phospho-D-erythronate + H(+) => CO2 + dihydroxyacetone phosphate"}
{"X":34375,"RHEA_ID":32477,"compounds":"betaine + 3 H(+) + 3 S-adenosyl-L-homocysteine => glycine + 3 S-adenosyl-L-methionine"}
{"X":34376,"RHEA_ID":42437,"DIRECTION":"LR","MASTER_ID":42436,"ecocyc":"RXN0-2461","metacyc":"RXN0-2461","compounds":"L-ascorbate(out) + N(pros)-phospho-L-histidyl-[protein] => L-ascorbate 6-phosphate(in) + L-histidyl-[protein]"}
{"X":34377,"RHEA_ID":32479,"DIRECTION":"UN","MASTER_ID":32479,"ec":"1.21.1.1","compounds":"2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + H(+) + 2 NADPH"}
{"X":34378,"RHEA_ID":52421,"DIRECTION":"LR","MASTER_ID":52420,"metacyc":"RXN-18665","compounds":"O-phospho-L-serine + thiosulfate => phosphate + S-sulfo-L-cysteine"}
{"X":34379,"RHEA_ID":42440,"compounds":"L-aspartate + NAD(+) = H(+) + iminosuccinate + NADH"}
{"X":34380,"RHEA_ID":42441,"compounds":"L-aspartate + NAD(+) => H(+) + iminosuccinate + NADH"}
{"X":34381,"RHEA_ID":32483,"DIRECTION":"UN","MASTER_ID":32483,"ec":"3.1.1.82","compounds":"H(+) + H2O + pheophorbide a = CO2 + methanol + pyropheophorbide a"}
{"X":34382,"RHEA_ID":52425,"DIRECTION":"LR","MASTER_ID":52424,"metacyc":"2.4.1.41-RXN","compounds":"L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP"}
{"X":34383,"RHEA_ID":32485,"compounds":"CO2 + methanol + pyropheophorbide a => H(+) + H2O + pheophorbide a"}
{"X":34384,"RHEA_ID":52427,"compounds":"L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP"}
{"X":34385,"RHEA_ID":32487,"DIRECTION":"UN","MASTER_ID":32487,"ec":"3.6.1.53","compounds":"CDP-choline + H2O = CMP + 2 H(+) + phosphocholine"}
{"X":34386,"RHEA_ID":52429,"compounds":"12-oxo-leukotriene B4 + H(+) + NADH => 12-oxo-(5S)-hydroxy-(6Z,8E,14Z)-eicosatrienoate + NAD(+)"}
{"X":34387,"RHEA_ID":32489,"compounds":"CMP + 2 H(+) + phosphocholine => CDP-choline + H2O"}
{"X":34388,"RHEA_ID":52431,"compounds":"12-oxo-leukotriene B4 + H(+) + NADH <=> 12-oxo-(5S)-hydroxy-(6Z,8E,14Z)-eicosatrienoate + NAD(+)"}
{"X":34389,"RHEA_ID":32491,"DIRECTION":"UN","MASTER_ID":32491,"ec":"1.14.14.113","compounds":"(1E,4E,8E)-alpha-humulene + O2 + reduced [NADPH--hemoprotein reductase] = 10-hydroxy-alpha-humulene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":34390,"RHEA_ID":52433,"compounds":"(R)-2,3-diaminopropanoate + H(+) + H2O => 2 NH4(+) + pyruvate"}
{"X":34391,"RHEA_ID":32493,"compounds":"10-hydroxy-alpha-humulene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (1E,4E,8E)-alpha-humulene + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":34392,"RHEA_ID":52435,"compounds":"(R)-2,3-diaminopropanoate + H(+) + H2O <=> 2 NH4(+) + pyruvate"}
{"X":34393,"RHEA_ID":32495,"DIRECTION":"UN","MASTER_ID":32495,"ec":"1.14.14.83","compounds":"geraniol + O2 + reduced [NADPH--hemoprotein reductase] = (6E)-8-hydroxygeraniol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":34394,"RHEA_ID":32496,"DIRECTION":"LR","MASTER_ID":32495,"metacyc":"RXN-8197","compounds":"geraniol + O2 + reduced [NADPH--hemoprotein reductase] => (6E)-8-hydroxygeraniol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":34395,"RHEA_ID":32497,"compounds":"(6E)-8-hydroxygeraniol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => geraniol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":34396,"RHEA_ID":52439,"compounds":"a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + an acyl-CoA <=> 2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + CoA"}
{"X":34397,"RHEA_ID":32499,"DIRECTION":"UN","MASTER_ID":32499,"ec":"1.14.13.153","metacyc":"%2b-SABINOL-DEHYDROGENASE-RXN","compounds":"(1R,5R)-sabinene + H(+) + NADPH + O2 = (1S,3R,5S)-sabinol + H2O + NADP(+)"}
{"X":34398,"RHEA_ID":42458,"compounds":"5alpha-cholesta-8,24-dien-3beta-ol => 4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol"}
{"X":34399,"RHEA_ID":32501,"compounds":"(1S,3R,5S)-sabinol + H2O + NADP(+) => (1R,5R)-sabinene + H(+) + NADPH + O2"}
{"X":34400,"RHEA_ID":52443,"compounds":"1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1->2)-D-myo-inositol] + GDP-alpha-D-mannose <=> a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+)"}
{"X":34401,"RHEA_ID":32503,"compounds":"linalool + O2 + reduced [NADPH--hemoprotein reductase] = (6E)-8-hydroxylinalool + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":34402,"RHEA_ID":42462,"compounds":"biphenyl-2,2',3-triol + NAD(+) => dibenzofuran + H(+) + NADH + O2"}
{"X":34403,"RHEA_ID":32505,"compounds":"(6E)-8-hydroxylinalool + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => linalool + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":34404,"RHEA_ID":42464,"compounds":"biphenyl-2,2',3-triol + O2 = 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + 2 H(+)"}
{"X":34405,"RHEA_ID":32507,"DIRECTION":"UN","MASTER_ID":32507,"ec":"3.1.1.83","compounds":"4-isopropenyl-7-methyloxepan-2-one + H2O = 6-hydroxy-3-isopropenylheptanoate + H(+)"}
{"X":34406,"RHEA_ID":42466,"compounds":"2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + 2 H(+) => biphenyl-2,2',3-triol + O2"}
{"X":34407,"RHEA_ID":32509,"compounds":"6-hydroxy-3-isopropenylheptanoate + H(+) => 4-isopropenyl-7-methyloxepan-2-one + H2O"}
{"X":34408,"RHEA_ID":42468,"DIRECTION":"UN","MASTER_ID":42468,"ec":"3.7.1.8","compounds":"2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O = 2-oxopent-4-enoate + salicylate"}
{"X":34409,"RHEA_ID":32511,"DIRECTION":"UN","MASTER_ID":32511,"ec":"3.1.1.83","compounds":"(4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O = (3R,6R)-6-hydroxy-3-isopropenylheptanoate + H(+)"}
{"X":34410,"RHEA_ID":42470,"compounds":"2-oxopent-4-enoate + salicylate => 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O"}
{"X":34411,"RHEA_ID":32513,"compounds":"(3R,6R)-6-hydroxy-3-isopropenylheptanoate + H(+) => (4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O"}
{"X":34412,"RHEA_ID":52455,"compounds":"16alpha-hydroxyestrone + UDP-alpha-D-glucuronate <=> 16alpha-hydroxyestrone 16-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":34413,"RHEA_ID":32515,"DIRECTION":"UN","MASTER_ID":32515,"ec":"3.1.1.83","compounds":"(4S,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O = (3S,6R)-6-hydroxy-3-isopropenylheptanoate + H(+)"}
{"X":34414,"RHEA_ID":32516,"DIRECTION":"LR","MASTER_ID":32515,"metacyc":"RXN-9421","compounds":"(4S,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O => (3S,6R)-6-hydroxy-3-isopropenylheptanoate + H(+)"}
{"X":34415,"RHEA_ID":32517,"compounds":"(3S,6R)-6-hydroxy-3-isopropenylheptanoate + H(+) => (4S,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O"}
{"X":34416,"RHEA_ID":52459,"compounds":"testosterone + UDP-alpha-D-glucuronate <=> H(+) + testosterone 17-O-(beta-D-glucuronate) + UDP"}
{"X":34417,"RHEA_ID":32519,"DIRECTION":"UN","MASTER_ID":32519,"ec":"2.1.1.255","compounds":"(2E)-geranyl diphosphate + S-adenosyl-L-methionine = (E)-2-methylgeranyl diphosphate + H(+) + S-adenosyl-L-homocysteine"}
{"X":34418,"RHEA_ID":42478,"compounds":"2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate => 2,2',3-trihydroxydiphenyl ether + H(+) + O2"}
{"X":34419,"RHEA_ID":32521,"compounds":"(E)-2-methylgeranyl diphosphate + H(+) + S-adenosyl-L-homocysteine => (2E)-geranyl diphosphate + S-adenosyl-L-methionine"}
{"X":34420,"RHEA_ID":52463,"compounds":"17beta-estradiol + UDP-alpha-D-glucuronate <=> 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":34421,"RHEA_ID":32523,"DIRECTION":"UN","MASTER_ID":32523,"ec":"2.4.1.279","compounds":"nigerose + phosphate = beta-D-glucose 1-phosphate + D-glucose"}
{"X":34422,"RHEA_ID":42482,"compounds":"(2Z,4E)-2-hydroxyhexa-2,4-dienedioate + catechol + H(+) => 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O"}
{"X":34423,"RHEA_ID":32525,"compounds":"beta-D-glucose 1-phosphate + D-glucose => nigerose + phosphate"}
{"X":34424,"RHEA_ID":52467,"compounds":"17beta-estradiol + UDP-alpha-D-glucuronate <=> 17beta-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":34425,"RHEA_ID":32527,"DIRECTION":"UN","MASTER_ID":32527,"ec":"2.4.1.280","compounds":"N,N'-diacetylchitobiose + phosphate = N-acetyl-alpha-D-glucosamine 1-phosphate + N-acetyl-D-glucosamine"}
{"X":34426,"RHEA_ID":42486,"compounds":"D-sorbitol 6-phosphate(in) + L-histidyl-[protein] => D-sorbitol(out) + N(pros)-phospho-L-histidyl-[protein]"}
{"X":34427,"RHEA_ID":32529,"compounds":"N-acetyl-alpha-D-glucosamine 1-phosphate + N-acetyl-D-glucosamine => N,N'-diacetylchitobiose + phosphate"}
{"X":34428,"RHEA_ID":42488,"compounds":"(3R)-3-amino-3-phenylpropanoyl-CoA + baccatin III = 3'-N-debenzoyl-2'-deoxytaxol + CoA"}
{"X":34429,"RHEA_ID":32531,"DIRECTION":"UN","MASTER_ID":32531,"ec":"2.4.1.281","compounds":"4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate = alpha-D-mannose 1-phosphate + D-glucose"}
{"X":34430,"RHEA_ID":42490,"compounds":"3'-N-debenzoyl-2'-deoxytaxol + CoA => (3R)-3-amino-3-phenylpropanoyl-CoA + baccatin III"}
{"X":34431,"RHEA_ID":32533,"compounds":"alpha-D-mannose 1-phosphate + D-glucose => 4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate"}
{"X":34432,"RHEA_ID":52475,"compounds":"16alpha,17beta-estriol + UDP-alpha-D-glucuronate <=> 16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":34433,"RHEA_ID":32535,"DIRECTION":"UN","MASTER_ID":32535,"ec":"4.2.1.132","compounds":"(2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H2O = 4-hydroxy-2-oxohexanoate"}
{"X":34434,"RHEA_ID":42494,"compounds":"3'-N-debenzoyltaxol + A + H2O => 3'-N-debenzoyl-2'-deoxytaxol + AH2 + O2"}
{"X":34435,"RHEA_ID":32537,"compounds":"4-hydroxy-2-oxohexanoate => (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H2O"}
{"X":34436,"RHEA_ID":42496,"compounds":"10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate = 10-deacetyl-2-debenzoylbaccatin III"}
{"X":34437,"RHEA_ID":32539,"DIRECTION":"UN","MASTER_ID":32539,"ec":"4.2.3.107","compounds":"(2E)-geranyl diphosphate = (+)-car-3-ene + diphosphate"}
{"X":34438,"RHEA_ID":32540,"DIRECTION":"LR","MASTER_ID":32539,"metacyc":"RXN-8565","compounds":"(2E)-geranyl diphosphate => (+)-car-3-ene + diphosphate"}
{"X":34439,"RHEA_ID":32541,"compounds":"(+)-car-3-ene + diphosphate => (2E)-geranyl diphosphate"}
{"X":34440,"RHEA_ID":35873,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + hexadecanoyl-CoA"}
{"X":34441,"RHEA_ID":32543,"DIRECTION":"UN","MASTER_ID":32543,"ec":"4.2.3.108","compounds":"(2E)-geranyl diphosphate + H2O = 1,8-cineole + diphosphate"}
{"X":34442,"RHEA_ID":42502,"DIRECTION":"RL","MASTER_ID":42500,"metacyc":"RXN-8854","compounds":"6-lactoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+)"}
{"X":34443,"RHEA_ID":32545,"compounds":"1,8-cineole + diphosphate => (2E)-geranyl diphosphate + H2O"}
{"X":34444,"RHEA_ID":35877,"compounds":"1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA"}
{"X":34445,"RHEA_ID":32547,"DIRECTION":"UN","MASTER_ID":32547,"ec":"4.2.3.110","compounds":"(2E)-geranyl diphosphate = (1R,5R)-sabinene + diphosphate"}
{"X":34446,"RHEA_ID":42506,"compounds":"6-acetamido-2-oxohexanoate + L-glutamate => 2-oxoglutarate + N(6)-acetyl-L-lysine"}
{"X":34447,"RHEA_ID":32549,"compounds":"(1R,5R)-sabinene + diphosphate => (2E)-geranyl diphosphate"}
{"X":34448,"RHEA_ID":42508,"compounds":"6-acetamido-2-oxohexanoate + H2O + NAD(+) = 5-acetamidopentanoate + CO2 + H(+) + NADH"}
{"X":34449,"RHEA_ID":32551,"DIRECTION":"UN","MASTER_ID":32551,"ec":"4.2.3.111","compounds":"(2E)-geranyl diphosphate + H2O = (S)-alpha-terpineol + diphosphate"}
{"X":34450,"RHEA_ID":42510,"compounds":"5-acetamidopentanoate + CO2 + H(+) + NADH => 6-acetamido-2-oxohexanoate + H2O + NAD(+)"}
{"X":34451,"RHEA_ID":32553,"compounds":"(S)-alpha-terpineol + diphosphate => (2E)-geranyl diphosphate + H2O"}
{"X":34452,"RHEA_ID":42512,"DIRECTION":"UN","MASTER_ID":42512,"ec":"3.5.1.63","compounds":"5-acetamidopentanoate + H2O = 5-aminopentanoate + acetate"}
{"X":34453,"RHEA_ID":32555,"DIRECTION":"UN","MASTER_ID":32555,"ec":"4.2.3.112","compounds":"(2E)-geranyl diphosphate + H2O = (R)-alpha-terpineol + diphosphate"}
{"X":34454,"RHEA_ID":32556,"DIRECTION":"LR","MASTER_ID":32555,"metacyc":"RXN-12983","compounds":"(2E)-geranyl diphosphate + H2O => (R)-alpha-terpineol + diphosphate"}
{"X":34455,"RHEA_ID":32557,"compounds":"(R)-alpha-terpineol + diphosphate => (2E)-geranyl diphosphate + H2O"}
{"X":34456,"RHEA_ID":52499,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":34457,"RHEA_ID":32559,"DIRECTION":"UN","MASTER_ID":32559,"ec":"4.2.3.114","compounds":"(2E)-geranyl diphosphate = diphosphate + gamma-terpinene"}
{"X":34458,"RHEA_ID":32560,"DIRECTION":"LR","MASTER_ID":32559,"metacyc":"RXN-8547","compounds":"(2E)-geranyl diphosphate => diphosphate + gamma-terpinene"}
{"X":34459,"RHEA_ID":32561,"compounds":"diphosphate + gamma-terpinene => (2E)-geranyl diphosphate"}
{"X":34460,"RHEA_ID":52503,"compounds":"(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (13R)-hydroxy-(9Z,11E)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":34461,"RHEA_ID":32563,"DIRECTION":"UN","MASTER_ID":32563,"ec":"4.2.3.115","compounds":"(2E)-geranyl diphosphate = alpha-terpinene + diphosphate"}
{"X":34462,"RHEA_ID":32564,"DIRECTION":"LR","MASTER_ID":32563,"metacyc":"RXN-8546","compounds":"(2E)-geranyl diphosphate => alpha-terpinene + diphosphate"}
{"X":34463,"RHEA_ID":32565,"compounds":"alpha-terpinene + diphosphate => (2E)-geranyl diphosphate"}
{"X":34464,"RHEA_ID":35897,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)"}
{"X":34465,"RHEA_ID":32567,"DIRECTION":"UN","MASTER_ID":32567,"ec":"4.2.3.116","compounds":"(2E)-geranyl diphosphate = (1R,4S)-camphene + diphosphate"}
{"X":34466,"RHEA_ID":32568,"DIRECTION":"LR","MASTER_ID":32567,"metacyc":"RXN-8576","compounds":"(2E)-geranyl diphosphate => (1R,4S)-camphene + diphosphate"}
{"X":34467,"RHEA_ID":32569,"compounds":"(1R,4S)-camphene + diphosphate => (2E)-geranyl diphosphate"}
{"X":34468,"RHEA_ID":52511,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":34469,"RHEA_ID":32571,"DIRECTION":"UN","MASTER_ID":32571,"ec":"4.2.3.118","compounds":"(E)-2-methylgeranyl diphosphate + H2O = 2-methylisoborneol + diphosphate"}
{"X":34470,"RHEA_ID":32572,"DIRECTION":"LR","MASTER_ID":32571,"metacyc":"RXN-12976","compounds":"(E)-2-methylgeranyl diphosphate + H2O => 2-methylisoborneol + diphosphate"}
{"X":34471,"RHEA_ID":35904,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":34472,"RHEA_ID":35905,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphate + CoA => 1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA"}
{"X":34473,"RHEA_ID":32575,"DIRECTION":"UN","MASTER_ID":32575,"ec":"4.2.3.121","compounds":"(2E)-geranyl diphosphate = (1R,5R)-alpha-pinene + diphosphate"}
{"X":34474,"RHEA_ID":32576,"DIRECTION":"LR","MASTER_ID":32575,"metacyc":"RXN-8563","compounds":"(2E)-geranyl diphosphate => (1R,5R)-alpha-pinene + diphosphate"}
{"X":34475,"RHEA_ID":32577,"compounds":"(1R,5R)-alpha-pinene + diphosphate => (2E)-geranyl diphosphate"}
{"X":34476,"RHEA_ID":52519,"compounds":"trans-4-hydroxy-L-proline + ubiquinone-10 <=> (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + H(+) + ubiquinol-10"}
{"X":34477,"RHEA_ID":32579,"DIRECTION":"UN","MASTER_ID":32579,"ec":"4.2.3.122","compounds":"(2E)-geranyl diphosphate = (1R,5R)-beta-pinene + diphosphate"}
{"X":34478,"RHEA_ID":32580,"DIRECTION":"LR","MASTER_ID":32579,"metacyc":"RXN-8564","compounds":"(2E)-geranyl diphosphate => (1R,5R)-beta-pinene + diphosphate"}
{"X":34479,"RHEA_ID":32581,"compounds":"(1R,5R)-beta-pinene + diphosphate => (2E)-geranyl diphosphate"}
{"X":34480,"RHEA_ID":35913,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate"}
{"X":34481,"RHEA_ID":32583,"DIRECTION":"UN","MASTER_ID":32583,"ec":"1.14.13.105","compounds":"dihydrocarvone + H(+) + NADPH + O2 = 6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)"}
{"X":34482,"RHEA_ID":32584,"DIRECTION":"LR","MASTER_ID":32583,"metacyc":"RXN-9395","compounds":"dihydrocarvone + H(+) + NADPH + O2 => 6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)"}
{"X":34483,"RHEA_ID":32585,"compounds":"6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+) => dihydrocarvone + H(+) + NADPH + O2"}
{"X":34484,"RHEA_ID":42544,"DIRECTION":"UN","MASTER_ID":42544,"ec":"5.4.99.28","compounds":"uridine(32) in tRNA = pseudouridine(32) in tRNA"}
{"X":34485,"RHEA_ID":32587,"compounds":"(1R,4R)-dihydrocarvone + H(+) + NADPH + O2 = (3R,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)"}
{"X":34486,"RHEA_ID":32588,"DIRECTION":"LR","MASTER_ID":32587,"metacyc":"RXN-9396","compounds":"(1R,4R)-dihydrocarvone + H(+) + NADPH + O2 => (3R,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)"}
{"X":34487,"RHEA_ID":32589,"compounds":"(3R,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+) => (1R,4R)-dihydrocarvone + H(+) + NADPH + O2"}
{"X":34488,"RHEA_ID":32590,"compounds":"(1R,4R)-dihydrocarvone + H(+) + NADPH + O2 <=> (3R,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)"}
{"X":34489,"RHEA_ID":42549,"DIRECTION":"LR","MASTER_ID":42548,"ecocyc":"RXN-11843","metacyc":"RXN-11843","compounds":"23S rRNA uridine(746) => 23S rRNA pseudouridine(746)"}
{"X":34490,"RHEA_ID":32592,"compounds":"(4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O => (3R,6S)-6-hydroxy-3,7-dimethyloctanoate + H(+)"}
{"X":34491,"RHEA_ID":32593,"compounds":"(3R,6S)-6-hydroxy-3,7-dimethyloctanoate + H(+) => (4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O"}
{"X":34492,"RHEA_ID":42552,"DIRECTION":"UN","MASTER_ID":42552,"ec":"5.4.99.42","compounds":"uridine(31) in tRNA = pseudouridine(31) in tRNA"}
{"X":34493,"RHEA_ID":42553,"compounds":"uridine(31) in tRNA => pseudouridine(31) in tRNA"}
{"X":34494,"RHEA_ID":32596,"compounds":"7-isopropyl-4-methyloxepan-2-one + H2O => 6-hydroxy-3,7-dimethyloctanoate + H(+)"}
{"X":34495,"RHEA_ID":32597,"compounds":"6-hydroxy-3,7-dimethyloctanoate + H(+) => 7-isopropyl-4-methyloxepan-2-one + H2O"}
{"X":34496,"RHEA_ID":42556,"DIRECTION":"UN","MASTER_ID":42556,"ec":"5.4.99.43","compounds":"uridine(2819) in 21S rRNA = pseudouridine(2819) in 21S rRNA"}
{"X":34497,"RHEA_ID":42557,"compounds":"uridine(2819) in 21S rRNA => pseudouridine(2819) in 21S rRNA"}
{"X":34498,"RHEA_ID":32600,"DIRECTION":"LR","MASTER_ID":32599,"metacyc":"RXN-9955","compounds":"7-hydroxy-4-isopropenyl-7-methyloxepan-2-one => 3-isopropenyl-6-oxoheptanoate + H(+)"}
{"X":34499,"RHEA_ID":32601,"compounds":"3-isopropenyl-6-oxoheptanoate + H(+) => 7-hydroxy-4-isopropenyl-7-methyloxepan-2-one"}
{"X":34500,"RHEA_ID":42560,"DIRECTION":"UN","MASTER_ID":42560,"ec":"5.4.99.44","compounds":"uridine(27/28) in mitochondrial tRNA = pseudouridine(27/28) in mitochondrial tRNA"}
{"X":34501,"RHEA_ID":42561,"compounds":"uridine(27/28) in mitochondrial tRNA => pseudouridine(27/28) in mitochondrial tRNA"}
{"X":34502,"RHEA_ID":32604,"compounds":"(6E)-8-hydroxygeraniol + NADP(+) => (6E)-8-oxogeraniol + H(+) + NADPH"}
{"X":34503,"RHEA_ID":32605,"compounds":"(6E)-8-oxogeraniol + H(+) + NADPH => (6E)-8-hydroxygeraniol + NADP(+)"}
{"X":34504,"RHEA_ID":42564,"DIRECTION":"UN","MASTER_ID":42564,"ec":"5.4.99.45","compounds":"uridine(38/39) in tRNA = pseudouridine(38/39) in tRNA"}
{"X":34505,"RHEA_ID":32607,"compounds":"(6E)-8-hydroxygeraniol + NADP(+) = (6E)-8-hydroxygeranial + H(+) + NADPH"}
{"X":34506,"RHEA_ID":32608,"compounds":"(6E)-8-hydroxygeraniol + NADP(+) => (6E)-8-hydroxygeranial + H(+) + NADPH"}
{"X":34507,"RHEA_ID":32609,"compounds":"(6E)-8-hydroxygeranial + H(+) + NADPH => (6E)-8-hydroxygeraniol + NADP(+)"}
{"X":34508,"RHEA_ID":42568,"compounds":"2,3-dihydroxy-p-cumate + O2 = 3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+)"}
{"X":34509,"RHEA_ID":32611,"compounds":"(6E)-8-hydroxygeranial + NADP(+) = (6E)-8-oxogeranial + H(+) + NADPH"}
{"X":34510,"RHEA_ID":32612,"DIRECTION":"LR","MASTER_ID":32611,"metacyc":"RXN-9369","compounds":"(6E)-8-hydroxygeranial + NADP(+) => (6E)-8-oxogeranial + H(+) + NADPH"}
{"X":34511,"RHEA_ID":32613,"compounds":"(6E)-8-oxogeranial + H(+) + NADPH => (6E)-8-hydroxygeranial + NADP(+)"}
{"X":34512,"RHEA_ID":45870,"compounds":"4-hydroxy-6-(non-8-en-1-yl)-pyran-2-one + 2 CO2 + 3 CoA => 9-decenoyl-CoA + 2 H(+) + 2 malonyl-CoA"}
{"X":34513,"RHEA_ID":32615,"compounds":"(6E)-8-oxogeraniol + NADP(+) = (6E)-8-oxogeranial + H(+) + NADPH"}
{"X":34514,"RHEA_ID":32616,"DIRECTION":"LR","MASTER_ID":32615,"metacyc":"RXN-9370","compounds":"(6E)-8-oxogeraniol + NADP(+) => (6E)-8-oxogeranial + H(+) + NADPH"}
{"X":34515,"RHEA_ID":32617,"compounds":"(6E)-8-oxogeranial + H(+) + NADPH => (6E)-8-oxogeraniol + NADP(+)"}
{"X":34516,"RHEA_ID":45874,"compounds":"4-hydroxy-6-(14-hydroxytetradecyl)-pyran-2-one + 2 CO2 + 3 CoA => 15-hydroxypentadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA"}
{"X":34517,"RHEA_ID":42577,"compounds":"2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + H2O => 2-methylpropanoate + 2-oxopent-4-enoate + H(+)"}
{"X":34518,"RHEA_ID":32620,"compounds":"L-threo-7,8-dihydrobiopterin + NADP(+) => H(+) + NADPH + sepiapterin"}
{"X":34519,"RHEA_ID":32621,"compounds":"H(+) + NADPH + sepiapterin => L-threo-7,8-dihydrobiopterin + NADP(+)"}
{"X":34520,"RHEA_ID":52563,"DIRECTION":"BI","MASTER_ID":52560,"metacyc":"RXN-18593","compounds":"2-dehydro-D-erythronate <=> 3-dehydro-D-erythronate"}
{"X":34521,"RHEA_ID":42581,"DIRECTION":"LR","MASTER_ID":42580,"ecocyc":"RXN0-2161","metacyc":"RXN0-2161","compounds":"ATP + L-serine + tRNA(Sec) => AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)"}
{"X":34522,"RHEA_ID":32624,"compounds":"L-threo-tetrahydrobiopterin + 2 NADP(+) => 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH"}
{"X":34523,"RHEA_ID":32625,"DIRECTION":"RL","MASTER_ID":32623,"metacyc":"RXN-13030","compounds":"6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH => L-threo-tetrahydrobiopterin + 2 NADP(+)"}
{"X":34524,"RHEA_ID":52567,"DIRECTION":"BI","MASTER_ID":52564,"metacyc":"RXN-18592","compounds":"2-dehydro-L-erythronate <=> 3-dehydro-L-erythronate"}
{"X":34525,"RHEA_ID":42585,"compounds":"1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O => 1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}
{"X":34526,"RHEA_ID":32628,"compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) => 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH"}
{"X":34527,"RHEA_ID":32629,"DIRECTION":"RL","MASTER_ID":32627,"metacyc":"RXN-8853","compounds":"6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+)"}
{"X":34528,"RHEA_ID":52571,"compounds":"epitestosterone + UDP-alpha-D-glucuronate <=> epitestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":34529,"RHEA_ID":42589,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":34530,"RHEA_ID":32632,"DIRECTION":"LR","MASTER_ID":32631,"metacyc":"RXN-12925","compounds":"erythromycin D + H(+) + NADPH + O2 => erythromycin C + H2O + NADP(+)"}
{"X":34531,"RHEA_ID":32633,"compounds":"erythromycin C + H2O + NADP(+) => erythromycin D + H(+) + NADPH + O2"}
{"X":34532,"RHEA_ID":45890,"compounds":"4-hydroxy-6-(11-methyldodecyl)-pyran-2-one + 2 CO2 + 3 CoA => 12-methyltridecanoyl-CoA + 2 H(+) + 2 malonyl-CoA"}
{"X":34533,"RHEA_ID":32635,"DIRECTION":"UN","MASTER_ID":32635,"ec":"1.14.14.84","compounds":"linalool + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (6E)-8-oxolinalool + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":34534,"RHEA_ID":32636,"DIRECTION":"LR","MASTER_ID":32635,"metacyc":"RXN-12967","compounds":"linalool + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (6E)-8-oxolinalool + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":34535,"RHEA_ID":32637,"compounds":"(6E)-8-oxolinalool + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => linalool + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}
{"X":34536,"RHEA_ID":52579,"compounds":"hexanoyl-CoA + NAD(+) <=> (2E)-hexenoyl-CoA + H(+) + NADH"}
{"X":34537,"RHEA_ID":42597,"DIRECTION":"LR","MASTER_ID":42596,"reactome":"R-HSA-2309787.1","compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 => prostaglandin G2"}
{"X":34538,"RHEA_ID":32640,"DIRECTION":"LR","MASTER_ID":32639,"metacyc":"RXN-12966","compounds":"(6E)-8-hydroxylinalool + O2 + reduced [NADPH--hemoprotein reductase] => (6E)-8-oxolinalool + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":34539,"RHEA_ID":32641,"compounds":"(6E)-8-oxolinalool + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (6E)-8-hydroxylinalool + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":34540,"RHEA_ID":52583,"compounds":"ATP + H2O + Pb(2+)(in) <=> ADP + H(+) + Pb(2+)(out) + phosphate"}
{"X":34541,"RHEA_ID":32643,"DIRECTION":"UN","MASTER_ID":32643,"ec":"1.17.2.2","compounds":"2 [Fe(III)cytochrome c] + H2O + lupanine = 17-hydroxylupanine + 2 [Fe(II)cytochrome c] + 2 H(+)"}
{"X":34542,"RHEA_ID":32644,"compounds":"2 [Fe(III)cytochrome c] + H2O + lupanine => 17-hydroxylupanine + 2 [Fe(II)cytochrome c] + 2 H(+)"}
{"X":34543,"RHEA_ID":32645,"compounds":"17-hydroxylupanine + 2 [Fe(II)cytochrome c] + 2 H(+) => 2 [Fe(III)cytochrome c] + H2O + lupanine"}
{"X":34544,"RHEA_ID":52587,"compounds":"chenodeoxycholoyl-CoA + NAD(+) <=> 7alpha-hydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH"}
{"X":34545,"RHEA_ID":42604,"compounds":"2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+)"}
{"X":34546,"RHEA_ID":32648,"DIRECTION":"LR","MASTER_ID":32647,"metacyc":"RXN-12923","compounds":"erythromycin C + S-adenosyl-L-methionine => erythromycin A + H(+) + S-adenosyl-L-homocysteine"}
{"X":34547,"RHEA_ID":32649,"compounds":"erythromycin A + H(+) + S-adenosyl-L-homocysteine => erythromycin C + S-adenosyl-L-methionine"}
{"X":34548,"RHEA_ID":42607,"compounds":"2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+)"}
{"X":34549,"RHEA_ID":42608,"compounds":"a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n H(+)(out) + NAD(+)"}
{"X":34550,"RHEA_ID":32652,"DIRECTION":"LR","MASTER_ID":32651,"metacyc":"RXN-12924","compounds":"erythromycin D + S-adenosyl-L-methionine => erythromycin B + H(+) + S-adenosyl-L-homocysteine"}
{"X":34551,"RHEA_ID":32653,"compounds":"erythromycin B + H(+) + S-adenosyl-L-homocysteine => erythromycin D + S-adenosyl-L-methionine"}
{"X":34552,"RHEA_ID":52595,"compounds":"deoxycholoyl-CoA + NAD(+) <=> 12alpha-hydroxy-3-oxocholan-24-oyl-CoA + H(+) + NADH"}
{"X":34553,"RHEA_ID":42612,"compounds":"a plastoquinone + (n+1) H(+)(in) + NADPH = a plastoquinol + n H(+)(out) + NADP(+)"}
{"X":34554,"RHEA_ID":32656,"compounds":"a carboxylate + eugenol + NADP(+) => a coniferyl ester + NADPH"}
{"X":34555,"RHEA_ID":32657,"compounds":"a coniferyl ester + NADPH => a carboxylate + eugenol + NADP(+)"}
{"X":34556,"RHEA_ID":52599,"compounds":"lithocholoyl-CoA + NAD(+) <=> 3-oxocholan-24-oyl-CoA + H(+) + NADH"}
{"X":34557,"RHEA_ID":32659,"DIRECTION":"UN","MASTER_ID":32659,"ec":"1.1.1.324","compounds":"(6E)-8-hydroxygeraniol + 2 NADP(+) = (6E)-8-oxogeranial + 2 H(+) + 2 NADPH"}
{"X":34558,"RHEA_ID":42617,"DIRECTION":"LR","MASTER_ID":42616,"ecocyc":"RXN-12894","metacyc":"RXN-12894","compounds":"(Z)-3-ureidoacrylate peracid + H(+) + H2O => (Z)-3-aminoperacrylic acid + CO2 + NH4(+)"}
{"X":34559,"RHEA_ID":42618,"compounds":"(Z)-3-aminoperacrylic acid + CO2 + NH4(+) => (Z)-3-ureidoacrylate peracid + H(+) + H2O"}
{"X":34560,"RHEA_ID":52603,"compounds":"L-methionine + propanoyl-CoA <=> CoA + H(+) + N-propanoyl-L-methioninate"}
{"X":34561,"RHEA_ID":32663,"DIRECTION":"UN","MASTER_ID":32663,"ec":"2.1.1.243","compounds":"5-guanidino-2-oxopentanoate + S-adenosyl-L-methionine = 5-guanidino-3-methyl-2-oxopentanoate + H(+) + S-adenosyl-L-homocysteine"}
{"X":34562,"RHEA_ID":32664,"DIRECTION":"LR","MASTER_ID":32663,"metacyc":"RXN-11456","compounds":"5-guanidino-2-oxopentanoate + S-adenosyl-L-methionine => 5-guanidino-3-methyl-2-oxopentanoate + H(+) + S-adenosyl-L-homocysteine"}
{"X":34563,"RHEA_ID":42622,"compounds":"(Z)-2-methylaminoacrylate + CO2 + NH4(+) => (Z)-2-methylureidoacrylate + H(+) + H2O"}
{"X":34564,"RHEA_ID":45922,"compounds":"4-hydroxy-6-(17-hydroxy-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA => 16-hydroxyhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA"}
{"X":34565,"RHEA_ID":32667,"DIRECTION":"UN","MASTER_ID":32667,"ec":"2.1.1.251","compounds":"coenzyme M + methanethiol = H(+) + hydrogen sulfide + methyl-coenzyme M"}
{"X":34566,"RHEA_ID":32668,"compounds":"coenzyme M + methanethiol => H(+) + hydrogen sulfide + methyl-coenzyme M"}
{"X":34567,"RHEA_ID":42626,"compounds":"(Z)-3-aminoacrylate + CO2 + NH4(+) => (Z)-3-ureidoacrylate + H(+) + H2O"}
{"X":34568,"RHEA_ID":52611,"compounds":"2-hydroxybutanoate + NADP(+) <=> 2-oxobutanoate + H(+) + NADPH"}
{"X":34569,"RHEA_ID":32671,"DIRECTION":"UN","MASTER_ID":32671,"ec":"2.7.1.176","compounds":"ATP + UDP-N-acetyl-alpha-D-glucosamine = ADP + H(+) + UDP-N-acetyl-alpha-D-glucosamine 3'-phosphate"}
{"X":34570,"RHEA_ID":32672,"compounds":"ATP + UDP-N-acetyl-alpha-D-glucosamine => ADP + H(+) + UDP-N-acetyl-alpha-D-glucosamine 3'-phosphate"}
{"X":34571,"RHEA_ID":32673,"compounds":"ADP + H(+) + UDP-N-acetyl-alpha-D-glucosamine 3'-phosphate => ATP + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":34572,"RHEA_ID":42631,"compounds":"S-adenosyl-L-methionine + uridine(747) in 23S rRNA <=> 5-methyluridine(747) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":34573,"RHEA_ID":42632,"DIRECTION":"UN","MASTER_ID":42632,"ec":"2.1.1.224","compounds":"adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 5'-deoxyadenosine + 8-methyladenosine(2503) in 23S rRNA + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine"}
{"X":34574,"RHEA_ID":32676,"DIRECTION":"LR","MASTER_ID":32675,"ecocyc":"TREHALA-RXN","metacyc":"TREHALA-RXN","compounds":"alpha,alpha-trehalose + H2O => alpha-D-glucose + beta-D-glucose"}
{"X":34575,"RHEA_ID":42634,"compounds":"5'-deoxyadenosine + 8-methyladenosine(2503) in 23S rRNA + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine => adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine"}
{"X":34576,"RHEA_ID":42635,"compounds":"adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine <=> 5'-deoxyadenosine + 8-methyladenosine(2503) in 23S rRNA + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine"}
{"X":34577,"RHEA_ID":42636,"DIRECTION":"UN","MASTER_ID":42636,"ec":"2.8.1.9","compounds":"AH2 + L-cysteine + Mo-molybdopterin = A + H2O + L-alanine + thio-Mo-molybdopterin"}
{"X":34578,"RHEA_ID":32680,"DIRECTION":"LR","MASTER_ID":32679,"metacyc":"RXN-8618","compounds":"(2E)-geranyl diphosphate + H2O => diphosphate + geraniol"}
{"X":34579,"RHEA_ID":42638,"compounds":"A + H2O + L-alanine + thio-Mo-molybdopterin => AH2 + L-cysteine + Mo-molybdopterin"}
{"X":34580,"RHEA_ID":52623,"DIRECTION":"BI","MASTER_ID":52620,"metacyc":"RXN-18585","compounds":"3-methylbutanoyl-CoA <=> 2,2-dimethylpropanoyl-CoA"}
{"X":34581,"RHEA_ID":42640,"DIRECTION":"UN","MASTER_ID":42640,"ec":"2.1.1.163","compounds":"a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H(+) + S-adenosyl-L-homocysteine"}
{"X":34582,"RHEA_ID":32684,"DIRECTION":"LR","MASTER_ID":32683,"metacyc":"RXN-15851","compounds":"5-hydroxymethylfurfural + 2 H2O + 3 O2 => 2,5-dicarboxyfuran + 2 H(+) + 3 H2O2"}
{"X":34583,"RHEA_ID":32685,"compounds":"2,5-dicarboxyfuran + 2 H(+) + 3 H2O2 => 5-hydroxymethylfurfural + 2 H2O + 3 O2"}
{"X":34584,"RHEA_ID":45942,"compounds":"4-hydroxy-6-(13-methyl-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA => 12-methyloctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA"}
{"X":34585,"RHEA_ID":42644,"DIRECTION":"UN","MASTER_ID":42644,"ec":"2.7.7.66","compounds":"2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[malonate decarboxylase ACP] = diphosphate + holo-[malonate decarboxylase ACP]"}
{"X":34586,"RHEA_ID":32688,"DIRECTION":"LR","MASTER_ID":32687,"metacyc":"RXN-5121","compounds":"(2E)-geranyl diphosphate => diphosphate + tricyclene"}
{"X":34587,"RHEA_ID":42646,"compounds":"diphosphate + holo-[malonate decarboxylase ACP] => 2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[malonate decarboxylase ACP]"}
{"X":34588,"RHEA_ID":42648,"compounds":"(2,5-ethylene furandicarboxylate)(n) + 2 H2O = (2,5-ethylene furandicarboxylate)(n-1) + 2,5-dicarboxyfuran + ethylene glycol + 2 H(+)"}
{"X":34589,"RHEA_ID":32692,"DIRECTION":"LR","MASTER_ID":32691,"metacyc":"RXN-5109","compounds":"(2E)-geranyl diphosphate => (E)-beta-ocimene + diphosphate"}
{"X":34590,"RHEA_ID":42650,"compounds":"(2,5-ethylene furandicarboxylate)(n-1) + 2,5-dicarboxyfuran + ethylene glycol + 2 H(+) => (2,5-ethylene furandicarboxylate)(n) + 2 H2O"}
{"X":34591,"RHEA_ID":42651,"compounds":"(2,5-ethylene furandicarboxylate)(n) + 2 H2O <=> (2,5-ethylene furandicarboxylate)(n-1) + 2,5-dicarboxyfuran + ethylene glycol + 2 H(+)"}
{"X":34592,"RHEA_ID":42652,"DIRECTION":"UN","MASTER_ID":42652,"ec":"2.1.1.314","compounds":"2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 3 H(+) + 4 S-adenosyl-L-homocysteine"}
{"X":34593,"RHEA_ID":32696,"compounds":"(2E)-geranyl diphosphate => (-)-car-3-ene + diphosphate"}
{"X":34594,"RHEA_ID":42654,"compounds":"diphthine methyl ester-[translation elongation factor 2] + 3 H(+) + 4 S-adenosyl-L-homocysteine => 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine"}
{"X":34595,"RHEA_ID":32698,"compounds":"(2E)-geranyl diphosphate <=> (-)-car-3-ene + diphosphate"}
{"X":34596,"RHEA_ID":42656,"DIRECTION":"UN","MASTER_ID":42656,"ec":"3.1.1.97","compounds":"diphthine methyl ester-[translation elongation factor 2] + H2O = diphthine-[translation elongation factor 2] + H(+) + methanol"}
{"X":34597,"RHEA_ID":32700,"DIRECTION":"LR","MASTER_ID":32699,"metacyc":"RXN-8430","compounds":"(2E,6E)-farnesyl diphosphate => beta-sesquiphellandrene + diphosphate"}
{"X":34598,"RHEA_ID":42658,"compounds":"diphthine-[translation elongation factor 2] + H(+) + methanol => diphthine methyl ester-[translation elongation factor 2] + H2O"}
{"X":34599,"RHEA_ID":42659,"compounds":"diphthine methyl ester-[translation elongation factor 2] + H2O <=> diphthine-[translation elongation factor 2] + H(+) + methanol"}
{"X":34600,"RHEA_ID":42660,"DIRECTION":"UN","MASTER_ID":42660,"ec":"1.1.1.374","compounds":"NAD(+) + UDP-N-acetyl-alpha-D-glucosamine = H(+) + NADH + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose"}
{"X":34601,"RHEA_ID":32704,"DIRECTION":"LR","MASTER_ID":32703,"metacyc":"RXN-11772","compounds":"all-trans-geranylgeranyl diphosphate + H2O => 8-hydroxycopalyl diphosphate"}
{"X":34602,"RHEA_ID":42662,"compounds":"H(+) + NADH + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose => NAD(+) + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":34603,"RHEA_ID":52646,"compounds":"5-phospho-D-xylonate + H(+) => D-xylono-1,4-lactone 5-phosphate + H2O"}
{"X":34604,"RHEA_ID":32707,"DIRECTION":"UN","MASTER_ID":32707,"ec":"5.5.1.22","compounds":"(2E)-geranyl diphosphate = (2R,4S)-bornyl diphosphate"}
{"X":34605,"RHEA_ID":32708,"DIRECTION":"LR","MASTER_ID":32707,"metacyc":"RXN-13002","compounds":"(2E)-geranyl diphosphate => (2R,4S)-bornyl diphosphate"}
{"X":34606,"RHEA_ID":42666,"compounds":"H(+) + L-arabinono-1,4-lactone + NADPH => L-arabinofuranose + NADP(+)"}
{"X":34607,"RHEA_ID":52649,"DIRECTION":"LR","MASTER_ID":52648,"metacyc":"RXN-19754","compounds":"H2O + L-arabino-1,4-lactone 5-phosphate => 5-phospho-L-arabinonate + H(+)"}
{"X":34608,"RHEA_ID":42668,"DIRECTION":"UN","MASTER_ID":42668,"ec":"1.1.1.377","compounds":"L-rhamnofuranose + NADP(+) = H(+) + L-rhamnono-1,4-lactone + NADPH"}
{"X":34609,"RHEA_ID":32712,"DIRECTION":"LR","MASTER_ID":32711,"metacyc":"RXN66-485","compounds":"a (3R)-hydroxyacyl-CoA + NAD(+) => a 3-oxoacyl-CoA + H(+) + NADH"}
{"X":34610,"RHEA_ID":32713,"compounds":"a 3-oxoacyl-CoA + H(+) + NADH => a (3R)-hydroxyacyl-CoA + NAD(+)"}
{"X":34611,"RHEA_ID":42670,"compounds":"H(+) + L-rhamnono-1,4-lactone + NADPH => L-rhamnofuranose + NADP(+)"}
{"X":34612,"RHEA_ID":52654,"compounds":"24-methylene-24-dihydrolanosterol + H(+) + S-adenosyl-L-homocysteine => lanosterol + S-adenosyl-L-methionine"}
{"X":34613,"RHEA_ID":32716,"DIRECTION":"LR","MASTER_ID":32715,"metacyc":"RXN-7745","compounds":"(2R,3S)-3-methylmalate + NAD(+) => 2-oxobutanoate + CO2 + NADH"}
{"X":34614,"RHEA_ID":32717,"compounds":"2-oxobutanoate + CO2 + NADH => (2R,3S)-3-methylmalate + NAD(+)"}
{"X":34615,"RHEA_ID":52657,"compounds":"a long-chain (3S)-hydroxy fatty acyl-CoA + NAD(+) => a long-chain 3-oxo-fatty acyl-CoA + H(+) + NADH"}
{"X":34616,"RHEA_ID":32719,"DIRECTION":"UN","MASTER_ID":32719,"ec":"1.14.14.42","compounds":"L-dihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-5-(methylsulfanyl)pentanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":34617,"RHEA_ID":32720,"DIRECTION":"LR","MASTER_ID":32719,"metacyc":"RXNQT-4309","compounds":"L-dihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-5-(methylsulfanyl)pentanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":34618,"RHEA_ID":32721,"compounds":"(E)-5-(methylsulfanyl)pentanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-dihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}
{"X":34619,"RHEA_ID":42678,"compounds":"H2O + L-alanin-3-yl L-histidin-5-yl sulfoxide => L-cysteine + L-histidine + O2"}
{"X":34620,"RHEA_ID":52662,"compounds":"AMP + an L-alpha-aminoacyl-[ACP] + diphosphate => an L-alpha-amino acid + ATP + holo-[ACP]"}
{"X":34621,"RHEA_ID":32724,"DIRECTION":"LR","MASTER_ID":32723,"metacyc":"RXNQT-4310","compounds":"L-trihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-6-(methylsulfanyl)hexanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":34622,"RHEA_ID":32725,"compounds":"(E)-6-(methylsulfanyl)hexanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-trihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}
{"X":34623,"RHEA_ID":52665,"compounds":"a short-chain (3S)-hydroxyacyl-CoA => a short-chain (2E)-enoyl-CoA + H2O"}
{"X":34624,"RHEA_ID":42683,"DIRECTION":"BI","MASTER_ID":42680,"metacyc":"RXN-15803","compounds":"2 hercynine + 2 L-selenocysteine + O2 <=> 2 H2O + 2 hercynylselenocysteine"}
{"X":34625,"RHEA_ID":32728,"DIRECTION":"LR","MASTER_ID":32727,"metacyc":"RXN-7697","compounds":"a very-long-chain acyl-CoA + H(+) + malonyl-CoA => a very-long-chain 3-oxoacyl-CoA + CO2 + CoA"}
{"X":34626,"RHEA_ID":32729,"compounds":"a very-long-chain 3-oxoacyl-CoA + CO2 + CoA => a very-long-chain acyl-CoA + H(+) + malonyl-CoA"}
{"X":34627,"RHEA_ID":42686,"compounds":"L-glutamate + S-(hercyn-2-yl)-L-cysteine S-oxide => H2O + L-gamma-glutamyl-hercynylcysteine S-oxide"}
{"X":34628,"RHEA_ID":52670,"DIRECTION":"RL","MASTER_ID":52668,"metacyc":"RXN-15006","compounds":"[amino group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + H(+) + NADPH => [amino group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + NADP(+) + phosphate"}
{"X":34629,"RHEA_ID":32732,"DIRECTION":"LR","MASTER_ID":32731,"metacyc":"RXN-19279","compounds":"a diacylglycerol + H2O => a fatty acid + a monoacylglycerol + H(+)"}
{"X":34630,"RHEA_ID":32733,"compounds":"a fatty acid + a monoacylglycerol + H(+) => a diacylglycerol + H2O"}
{"X":34631,"RHEA_ID":42690,"compounds":"A + ergothioneine + NH4(+) + pyruvate => AH2 + H(+) + S-(hercyn-2-yl)-L-cysteine S-oxide"}
{"X":34632,"RHEA_ID":32735,"DIRECTION":"UN","MASTER_ID":32735,"ec":"2.1.1.71","compounds":"1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine"}
{"X":34633,"RHEA_ID":32736,"DIRECTION":"LR","MASTER_ID":32735,"metacyc":"2.1.1.71-RXN","compounds":"1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine => 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine"}
{"X":34634,"RHEA_ID":32737,"compounds":"1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine => 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine"}
{"X":34635,"RHEA_ID":42694,"compounds":"[(1->4)-alpha-D-glucosyl](n+2) + phosphate => [(1->4)-alpha-D-glucosyl](n) + alpha-maltose 1-phosphate"}
{"X":34636,"RHEA_ID":32740,"DIRECTION":"LR","MASTER_ID":32739,"metacyc":"RXN4FS-2","compounds":"1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine => a 1,2-diacyl-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine"}
{"X":34637,"RHEA_ID":32741,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine => 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine"}
{"X":34638,"RHEA_ID":42698,"compounds":"NH4(+) + pyruvate + selnoneine thione => H2O + hercynylselenocysteine"}
{"X":34639,"RHEA_ID":42699,"compounds":"H2O + hercynylselenocysteine <=> NH4(+) + pyruvate + selnoneine thione"}
{"X":34640,"RHEA_ID":32744,"compounds":"L-homocysteine + O-acetyl-L-serine => acetate + H(+) + L,L-cystathionine"}
{"X":34641,"RHEA_ID":42701,"DIRECTION":"LR","MASTER_ID":42700,"ecocyc":"RXN-11483","metacyc":"RXN-11483","compounds":"6-carboxyhexanoyl-[ACP] methyl ester + H2O => 6-carboxyhexanoyl-[ACP] + H(+) + methanol"}
{"X":34642,"RHEA_ID":42702,"compounds":"6-carboxyhexanoyl-[ACP] + H(+) + methanol => 6-carboxyhexanoyl-[ACP] methyl ester + H2O"}
{"X":34643,"RHEA_ID":32747,"compounds":"ethanolamine(in) = ethanolamine(out)"}
{"X":34644,"RHEA_ID":32748,"compounds":"ethanolamine(in) => ethanolamine(out)"}
{"X":34645,"RHEA_ID":42705,"DIRECTION":"LR","MASTER_ID":42704,"metacyc":"RXN-15801","compounds":"hercynine + L-cysteine + O2 => H2O + S-(hercyn-2-yl)-L-cysteine S-oxide"}
{"X":34646,"RHEA_ID":32750,"compounds":"ethanolamine(in) <=> ethanolamine(out)"}
{"X":34647,"RHEA_ID":32751,"compounds":"choline(out) = choline(in)"}
{"X":34648,"RHEA_ID":32752,"DIRECTION":"LR","MASTER_ID":32751,"reactome":"R-HSA-549322.1","compounds":"choline(out) => choline(in)"}
{"X":34649,"RHEA_ID":32752,"DIRECTION":"LR","MASTER_ID":32751,"reactome":"R-HSA-561054.3","compounds":"choline(out) => choline(in)"}
{"X":34650,"RHEA_ID":32753,"DIRECTION":"RL","MASTER_ID":32751,"reactome":"R-HSA-549279.3","compounds":"choline(in) => choline(out)"}
{"X":34651,"RHEA_ID":52694,"compounds":"3-phenylpyruvate + H(+) + NADPH => 3-phenyllactate + NADP(+)"}
{"X":34652,"RHEA_ID":32753,"DIRECTION":"RL","MASTER_ID":32751,"reactome":"R-HSA-549129.1","compounds":"choline(in) => choline(out)"}
{"X":34653,"RHEA_ID":42713,"DIRECTION":"LR","MASTER_ID":42712,"ecocyc":"TRNA-URACIL-5--METHYLTRANSFERASE-RXN","metacyc":"TRNA-URACIL-5--METHYLTRANSFERASE-RXN","compounds":"S-adenosyl-L-methionine + uridine(54) in tRNA => 5-methyluridine(54) in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":34654,"RHEA_ID":32754,"compounds":"choline(out) <=> choline(in)"}
{"X":34655,"RHEA_ID":32755,"DIRECTION":"UN","MASTER_ID":32755,"ec":"1.14.20.5","compounds":"(S)-naringenin + 2-oxoglutarate + O2 = apigenin + CO2 + H(+) + H2O + succinate"}
{"X":34656,"RHEA_ID":32756,"DIRECTION":"LR","MASTER_ID":32755,"metacyc":"RXN-7686","compounds":"(S)-naringenin + 2-oxoglutarate + O2 => apigenin + CO2 + H(+) + H2O + succinate"}
{"X":34657,"RHEA_ID":42717,"DIRECTION":"LR","MASTER_ID":42716,"ecocyc":"RXN0-2281","metacyc":"RXN0-2281","compounds":"(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + H2O + selenophosphate => 5-methylaminomethyl-2-selenouridine(34) in tRNA + diphosphate + phosphate + thiogeraniol"}
{"X":34658,"RHEA_ID":42718,"compounds":"5-methylaminomethyl-2-selenouridine(34) in tRNA + diphosphate + phosphate + thiogeraniol => (2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + H2O + selenophosphate"}
{"X":34659,"RHEA_ID":42719,"compounds":"(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + H2O + selenophosphate <=> 5-methylaminomethyl-2-selenouridine(34) in tRNA + diphosphate + phosphate + thiogeraniol"}
{"X":34660,"RHEA_ID":32760,"DIRECTION":"LR","MASTER_ID":32759,"metacyc":"RXN-13074","compounds":"L-lysine => (3R)-3-methyl-D-ornithine"}
{"X":34661,"RHEA_ID":42721,"DIRECTION":"LR","MASTER_ID":42720,"ecocyc":"RXN-11845","metacyc":"RXN-11845","compounds":"S-adenosyl-L-methionine + uridine(2552) in 23S rRNA => 2'-O-methyluridine(2552) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":34662,"RHEA_ID":42722,"compounds":"2'-O-methyluridine(2552) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(2552) in 23S rRNA"}
{"X":34663,"RHEA_ID":42723,"compounds":"S-adenosyl-L-methionine + uridine(2552) in 23S rRNA <=> 2'-O-methyluridine(2552) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":34664,"RHEA_ID":32764,"DIRECTION":"LR","MASTER_ID":32763,"metacyc":"RXN-13080","compounds":"(3R)-3-methyl-D-ornithine + L-lysine => (3R)-3-methyl-D-ornithyl-N(6)-L-lysine + H2O"}
{"X":34665,"RHEA_ID":42725,"DIRECTION":"LR","MASTER_ID":42724,"metacyc":"RXN-11581","compounds":"guanosine(2922) in 27S pre-rRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine(2922) in 27S pre-rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":34666,"RHEA_ID":32766,"compounds":"(3R)-3-methyl-D-ornithine + L-lysine <=> (3R)-3-methyl-D-ornithyl-N(6)-L-lysine + H2O"}
{"X":34667,"RHEA_ID":42727,"compounds":"guanosine(2922) in 27S pre-rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(2922) in 27S pre-rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":34668,"RHEA_ID":32768,"DIRECTION":"LR","MASTER_ID":32767,"metacyc":"RXN-12477","compounds":"cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine => 2'-O-methylcytidine(4) in tRNA(Pro) + H(+) + S-adenosyl-L-homocysteine"}
{"X":34669,"RHEA_ID":32769,"compounds":"2'-O-methylcytidine(4) in tRNA(Pro) + H(+) + S-adenosyl-L-homocysteine => cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine"}
{"X":34670,"RHEA_ID":32770,"compounds":"cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(4) in tRNA(Pro) + H(+) + S-adenosyl-L-homocysteine"}
{"X":34671,"RHEA_ID":42731,"compounds":"S-adenosyl-L-methionine + uridine(2791) in 21S rRNA <=> 2'-O-methyluridine(2791) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":34672,"RHEA_ID":32772,"DIRECTION":"LR","MASTER_ID":32771,"metacyc":"RXN-13319","compounds":"2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate => 2,6-dioxo-6-phenylhexa-3-enoate"}
{"X":34673,"RHEA_ID":42733,"DIRECTION":"LR","MASTER_ID":42732,"ecocyc":"RXN-11578","metacyc":"RXN-11578","compounds":"guanosine(527) in 16S rRNA + S-adenosyl-L-methionine => N(7)-methylguanosine(527) in 16S rRNA + S-adenosyl-L-homocysteine"}
{"X":34674,"RHEA_ID":32774,"compounds":"2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate <=> 2,6-dioxo-6-phenylhexa-3-enoate"}
{"X":34675,"RHEA_ID":42735,"compounds":"guanosine(527) in 16S rRNA + S-adenosyl-L-methionine <=> N(7)-methylguanosine(527) in 16S rRNA + S-adenosyl-L-homocysteine"}
{"X":34676,"RHEA_ID":32776,"compounds":"(2-aminoethyl)phosphonate(out) + ATP + H2O => (2-aminoethyl)phosphonate(in) + ADP + H(+) + phosphate"}
{"X":34677,"RHEA_ID":32777,"compounds":"(2-aminoethyl)phosphonate(in) + ADP + H(+) + phosphate => (2-aminoethyl)phosphonate(out) + ATP + H2O"}
{"X":34678,"RHEA_ID":32778,"compounds":"(2-aminoethyl)phosphonate(out) + ATP + H2O <=> (2-aminoethyl)phosphonate(in) + ADP + H(+) + phosphate"}
{"X":34679,"RHEA_ID":32779,"compounds":"ATP + Co(2+)(out) + H2O = ADP + Co(2+)(in) + H(+) + phosphate"}
{"X":34680,"RHEA_ID":32780,"DIRECTION":"LR","MASTER_ID":32779,"ecocyc":"TRANS-RXN-141A","metacyc":"TRANS-RXN-141A","compounds":"ATP + Co(2+)(out) + H2O => ADP + Co(2+)(in) + H(+) + phosphate"}
{"X":34681,"RHEA_ID":32781,"compounds":"ADP + Co(2+)(in) + H(+) + phosphate => ATP + Co(2+)(out) + H2O"}
{"X":34682,"RHEA_ID":42742,"compounds":"H(+) + N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine => guanosine(2445) in 23S rRNA + S-adenosyl-L-methionine"}
{"X":34683,"RHEA_ID":52730,"compounds":"a 12-sulfojasmonate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + a 12-hydroxyjasmonate"}
{"X":34684,"RHEA_ID":32784,"compounds":"ATP + betaine(out) + H2O => ADP + betaine(in) + H(+) + phosphate"}
{"X":34685,"RHEA_ID":32785,"compounds":"ADP + betaine(in) + H(+) + phosphate => ATP + betaine(out) + H2O"}
{"X":34686,"RHEA_ID":32786,"compounds":"ATP + betaine(out) + H2O <=> ADP + betaine(in) + H(+) + phosphate"}
{"X":34687,"RHEA_ID":52734,"compounds":"adenosine 3',5'-bisphosphate + an 11-sulfojasmonate + H(+) => 3'-phosphoadenylyl sulfate + an 11-hydroxyjasmonate"}
{"X":34688,"RHEA_ID":32788,"compounds":"ATP + H2O + L-ectoine(out) => ADP + H(+) + L-ectoine(in) + phosphate"}
{"X":34689,"RHEA_ID":32789,"compounds":"ADP + H(+) + L-ectoine(in) + phosphate => ATP + H2O + L-ectoine(out)"}
{"X":34690,"RHEA_ID":42750,"compounds":"5-methylcytidine(967) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(967) in 16S rRNA + S-adenosyl-L-methionine"}
{"X":34691,"RHEA_ID":42751,"compounds":"cytidine(967) in 16S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(967) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":34692,"RHEA_ID":32792,"compounds":"L-ectoine(in) => L-ectoine(out)"}
{"X":34693,"RHEA_ID":32793,"compounds":"L-ectoine(out) => L-ectoine(in)"}
{"X":34694,"RHEA_ID":42754,"compounds":"H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine => pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine"}
{"X":34695,"RHEA_ID":42755,"compounds":"pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine"}
{"X":34696,"RHEA_ID":32796,"compounds":"ATP + H2O + L-cysteine(out) => ADP + H(+) + L-cysteine(in) + phosphate"}
{"X":34697,"RHEA_ID":32797,"compounds":"ADP + H(+) + L-cysteine(in) + phosphate => ATP + H2O + L-cysteine(out)"}
{"X":34698,"RHEA_ID":42758,"compounds":"5-methylcytidine(1407) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1407) in 16S rRNA + S-adenosyl-L-methionine"}
{"X":34699,"RHEA_ID":42759,"compounds":"cytidine(1407) in 16S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(1407) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":34700,"RHEA_ID":32800,"DIRECTION":"LR","MASTER_ID":32799,"reactome":"R-HSA-507875.3","compounds":"urea(in) => urea(out)"}
{"X":34701,"RHEA_ID":32800,"DIRECTION":"LR","MASTER_ID":32799,"reactome":"R-HSA-444126.1","compounds":"urea(in) => urea(out)"}
{"X":34702,"RHEA_ID":42762,"compounds":"(2R)-3-phosphoglycerate + 2 H(+) + NADH => D-glyceraldehyde 3-phosphate + H2O + NAD(+)"}
{"X":34703,"RHEA_ID":32802,"compounds":"urea(in) <=> urea(out)"}
{"X":34704,"RHEA_ID":42764,"DIRECTION":"UN","MASTER_ID":42764,"ec":"1.17.98.3","metacyc":"RXN-15617","compounds":"formate + 2 H(+) + oxidized coenzyme F420-(gamma-Glu)(n) = CO2 + reduced coenzyme F420-(gamma-Glu)(n)"}
{"X":34705,"RHEA_ID":32804,"compounds":"ATP + H2O + urea(out) => ADP + H(+) + phosphate + urea(in)"}
{"X":34706,"RHEA_ID":42766,"compounds":"CO2 + reduced coenzyme F420-(gamma-Glu)(n) => formate + 2 H(+) + oxidized coenzyme F420-(gamma-Glu)(n)"}
{"X":34707,"RHEA_ID":32806,"compounds":"ATP + H2O + urea(out) <=> ADP + H(+) + phosphate + urea(in)"}
{"X":34708,"RHEA_ID":42768,"DIRECTION":"UN","MASTER_ID":42768,"ec":"1.1.1.375","compounds":"a (2S)-2-hydroxycarboxylate + NADP(+) = a 2-oxocarboxylate + H(+) + NADPH"}
{"X":34709,"RHEA_ID":32808,"compounds":"thiosulfate(in) => thiosulfate(out)"}
{"X":34710,"RHEA_ID":42770,"compounds":"a 2-oxocarboxylate + H(+) + NADPH => a (2S)-2-hydroxycarboxylate + NADP(+)"}
{"X":34711,"RHEA_ID":32810,"compounds":"thiosulfate(in) <=> thiosulfate(out)"}
{"X":34712,"RHEA_ID":42772,"DIRECTION":"UN","MASTER_ID":42772,"ec":"2.1.1.179","compounds":"guanosine(1405) in 16S rRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(1405) in 16S rRNA + S-adenosyl-L-homocysteine"}
{"X":34713,"RHEA_ID":32812,"compounds":"benzoate(in) => benzoate(out)"}
{"X":34714,"RHEA_ID":42774,"compounds":"N(7)-methylguanosine(1405) in 16S rRNA + S-adenosyl-L-homocysteine => guanosine(1405) in 16S rRNA + S-adenosyl-L-methionine"}
{"X":34715,"RHEA_ID":32814,"compounds":"benzoate(in) <=> benzoate(out)"}
{"X":34716,"RHEA_ID":42776,"DIRECTION":"UN","MASTER_ID":42776,"ec":"2.1.1.180","compounds":"adenosine(1408) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(1408) in 16S rRNA + S-adenosyl-L-homocysteine"}
{"X":34717,"RHEA_ID":32816,"compounds":"Hg(2+)(in) => Hg(2+)(out)"}
{"X":34718,"RHEA_ID":42778,"compounds":"H(+) + N(1)-methyladenosine(1408) in 16S rRNA + S-adenosyl-L-homocysteine => adenosine(1408) in 16S rRNA + S-adenosyl-L-methionine"}
{"X":34719,"RHEA_ID":32818,"compounds":"Hg(2+)(in) <=> Hg(2+)(out)"}
{"X":34720,"RHEA_ID":42780,"DIRECTION":"UN","MASTER_ID":42780,"ec":"2.1.1.183","compounds":"adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine"}
{"X":34721,"RHEA_ID":32820,"compounds":"chromate(in) => chromate(out)"}
{"X":34722,"RHEA_ID":42782,"compounds":"4 H(+) + N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine => adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine"}
{"X":34723,"RHEA_ID":32822,"compounds":"chromate(in) <=> chromate(out)"}
{"X":34724,"RHEA_ID":42784,"DIRECTION":"UN","MASTER_ID":42784,"ec":"2.1.1.184","compounds":"adenosine(2085) in 23S rRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(6)-dimethyladenosine(2085) in 23S rRNA + 2 S-adenosyl-L-homocysteine"}
{"X":34725,"RHEA_ID":32824,"compounds":"phosphate(in) => phosphate(out)"}
{"X":34726,"RHEA_ID":42786,"compounds":"2 H(+) + N(6)-dimethyladenosine(2085) in 23S rRNA + 2 S-adenosyl-L-homocysteine => adenosine(2085) in 23S rRNA + 2 S-adenosyl-L-methionine"}
{"X":34727,"RHEA_ID":32826,"compounds":"phosphate(in) <=> phosphate(out)"}
{"X":34728,"RHEA_ID":42788,"DIRECTION":"UN","MASTER_ID":42788,"ec":"2.1.1.186","compounds":"cytidine(2498) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(2498) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":34729,"RHEA_ID":32828,"compounds":"ATP + H2O + methionine(out) => ADP + H(+) + methionine(in) + phosphate"}
{"X":34730,"RHEA_ID":42790,"compounds":"2'-O-methylcytidine(2498) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(2498) in 23S rRNA + S-adenosyl-L-methionine"}
{"X":34731,"RHEA_ID":32830,"compounds":"ATP + H2O + methionine(out) <=> ADP + H(+) + methionine(in) + phosphate"}
{"X":34732,"RHEA_ID":42792,"compounds":"cholesterol + hexadecanoyl-CoA = cholesteryl hexadecanoate + CoA"}
{"X":34733,"RHEA_ID":32832,"compounds":"cob(III)alamin(in) => cob(III)alamin(out)"}
{"X":34734,"RHEA_ID":42794,"compounds":"cholesteryl hexadecanoate + CoA => cholesterol + hexadecanoyl-CoA"}
{"X":34735,"RHEA_ID":32834,"compounds":"cob(III)alamin(in) <=> cob(III)alamin(out)"}
{"X":34736,"RHEA_ID":42796,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + cholesterol = cholesteryl (9Z,12Z)-octadecadienoate + CoA"}
{"X":34737,"RHEA_ID":32836,"compounds":"4-(trimethylamino)butanoate(in) => 4-(trimethylamino)butanoate(out)"}
{"X":34738,"RHEA_ID":42798,"compounds":"cholesteryl (9Z,12Z)-octadecadienoate + CoA => (9Z,12Z)-octadecadienoyl-CoA + cholesterol"}
{"X":34739,"RHEA_ID":32838,"compounds":"4-(trimethylamino)butanoate(in) <=> 4-(trimethylamino)butanoate(out)"}
{"X":34740,"RHEA_ID":42800,"DIRECTION":"UN","MASTER_ID":42800,"ec":"1.3.8.2","compounds":"15-cis-4,4'-diapophytoene + 3 FAD + 3 H(+) = all-trans-4,4'-diaponeurosporene + 3 FADH2"}
{"X":34741,"RHEA_ID":32844,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycerol => a 1-acyl-sn-glycero-3-phosphocholine + a triacyl-sn-glycerol"}
{"X":34742,"RHEA_ID":42802,"compounds":"all-trans-4,4'-diaponeurosporene + 3 FADH2 => 15-cis-4,4'-diapophytoene + 3 FAD + 3 H(+)"}
{"X":34743,"RHEA_ID":32846,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycerol <=> a 1-acyl-sn-glycero-3-phosphocholine + a triacyl-sn-glycerol"}
{"X":34744,"RHEA_ID":32847,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycerol = a 1-acyl-sn-glycero-3-phosphoethanolamine + a triacyl-sn-glycerol"}
{"X":34745,"RHEA_ID":32848,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycerol => a 1-acyl-sn-glycero-3-phosphoethanolamine + a triacyl-sn-glycerol"}
{"X":34746,"RHEA_ID":32849,"compounds":"a 1-acyl-sn-glycero-3-phosphoethanolamine + a triacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycerol"}
{"X":34747,"RHEA_ID":32850,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycerol <=> a 1-acyl-sn-glycero-3-phosphoethanolamine + a triacyl-sn-glycerol"}
{"X":34748,"RHEA_ID":42808,"DIRECTION":"UN","MASTER_ID":42808,"ec":"1.8.98.3","compounds":"2 H(+) + 3 H2O + hydrogen sulfide + 3 oxidized coenzyme F420-(gamma-Glu)(n) = 3 reduced coenzyme F420-(gamma-Glu)(n) + sulfite"}
{"X":34749,"RHEA_ID":32852,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol => a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine"}
{"X":34750,"RHEA_ID":42810,"compounds":"3 reduced coenzyme F420-(gamma-Glu)(n) + sulfite => 2 H(+) + 3 H2O + hydrogen sulfide + 3 oxidized coenzyme F420-(gamma-Glu)(n)"}
{"X":34751,"RHEA_ID":32854,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol <=> a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine"}
{"X":34752,"RHEA_ID":42812,"compounds":"cholesterol + octadecanoyl-CoA = cholesteryl octadecanoate + CoA"}
{"X":34753,"RHEA_ID":32856,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol => a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine"}
{"X":34754,"RHEA_ID":42814,"compounds":"cholesteryl octadecanoate + CoA => cholesterol + octadecanoyl-CoA"}
{"X":34755,"RHEA_ID":32858,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol <=> a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine"}
{"X":34756,"RHEA_ID":42816,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA"}
{"X":34757,"RHEA_ID":32860,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol => a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine"}
{"X":34758,"RHEA_ID":42818,"compounds":"cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol"}
{"X":34759,"RHEA_ID":32862,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol <=> a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine"}
{"X":34760,"RHEA_ID":42820,"DIRECTION":"UN","MASTER_ID":42820,"ec":"1.14.13.200","compounds":"2 H(+) + 2 NADPH + 2 O2 + tetracenomycin A2 = H2O + 2 NADP(+) + tetracenomycin C"}
{"X":34761,"RHEA_ID":32864,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycerol => a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine"}
{"X":34762,"RHEA_ID":32865,"compounds":"a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycerol"}
{"X":34763,"RHEA_ID":32866,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycerol <=> a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine"}
{"X":34764,"RHEA_ID":32867,"compounds":"myo-inositol(out) = myo-inositol(in)"}
{"X":34765,"RHEA_ID":42825,"compounds":"2 H(+) + 2 NADH + 2 O2 + tetracenomycin A2 => H2O + 2 NAD(+) + tetracenomycin C"}
{"X":34766,"RHEA_ID":42826,"compounds":"H2O + 2 NAD(+) + tetracenomycin C => 2 H(+) + 2 NADH + 2 O2 + tetracenomycin A2"}
{"X":34767,"RHEA_ID":32870,"compounds":"myo-inositol(out) <=> myo-inositol(in)"}
{"X":34768,"RHEA_ID":32871,"compounds":"a 2-acylglycerol + H2O = a carboxylate + glycerol + H(+)"}
{"X":34769,"RHEA_ID":42829,"DIRECTION":"LR","MASTER_ID":42828,"metacyc":"RXN-15676","compounds":"2-hydroxy-5-methyl-1-naphthoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2,7-dihydroxy-5-methyl-1-naphthoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":34770,"RHEA_ID":32873,"compounds":"a carboxylate + glycerol + H(+) => a 2-acylglycerol + H2O"}
{"X":34771,"RHEA_ID":32874,"compounds":"a 2-acylglycerol + H2O <=> a carboxylate + glycerol + H(+)"}
{"X":34772,"RHEA_ID":32875,"compounds":"a 1-acyl-sn-glycerol + H2O = a fatty acid + glycerol + H(+)"}
{"X":34773,"RHEA_ID":42833,"DIRECTION":"LR","MASTER_ID":42832,"metacyc":"RXN-15769","compounds":"(2E)-octenal + H(+) + pyruvate => (S)-3-acetyloctanal + CO2"}
{"X":34774,"RHEA_ID":32877,"compounds":"a fatty acid + glycerol + H(+) => a 1-acyl-sn-glycerol + H2O"}
{"X":34775,"RHEA_ID":32878,"compounds":"a 1-acyl-sn-glycerol + H2O <=> a fatty acid + glycerol + H(+)"}
{"X":34776,"RHEA_ID":32879,"DIRECTION":"UN","MASTER_ID":32879,"ec":"1.1.1.327","compounds":"(1R,4R,5R)-5-hydroxycamphor + NAD(+) = (1R,4R)-bornane-2,5-dione + H(+) + NADH"}
{"X":34777,"RHEA_ID":42837,"compounds":"acetyl-CoA + 7 H(+) + 5 malonyl-CoA + 3 NADPH => 5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 4 H2O + 3 NADP(+)"}
{"X":34778,"RHEA_ID":42838,"compounds":"5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 4 H2O + 3 NADP(+) => acetyl-CoA + 7 H(+) + 5 malonyl-CoA + 3 NADPH"}
{"X":34779,"RHEA_ID":42839,"DIRECTION":"BI","MASTER_ID":42836,"metacyc":"RXN-15688","compounds":"acetyl-CoA + 7 H(+) + 5 malonyl-CoA + 3 NADPH <=> 5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 4 H2O + 3 NADP(+)"}
{"X":34780,"RHEA_ID":32883,"DIRECTION":"UN","MASTER_ID":32883,"ec":"1.3.1.92","compounds":"(11R)-dihydroartemisinic aldehyde + NADP(+) = (+)-artemisinic aldehyde + H(+) + NADPH"}
{"X":34781,"RHEA_ID":32884,"compounds":"(11R)-dihydroartemisinic aldehyde + NADP(+) => (+)-artemisinic aldehyde + H(+) + NADPH"}
{"X":34782,"RHEA_ID":42842,"compounds":"2-hydroxy-5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 3 H2O + 2 NADP(+) => acetyl-CoA + 6 H(+) + 5 malonyl-CoA + 2 NADPH"}
{"X":34783,"RHEA_ID":52830,"compounds":"(3S,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+) => (1S,4R)-isodihydrocarvone + H(+) + NADPH + O2"}
{"X":34784,"RHEA_ID":32887,"DIRECTION":"UN","MASTER_ID":32887,"ec":"1.13.11.63","compounds":"all-trans-beta-carotene + O2 = 2 all-trans-retinal"}
{"X":34785,"RHEA_ID":32888,"DIRECTION":"LR","MASTER_ID":32887,"metacyc":"RXN-13374","compounds":"all-trans-beta-carotene + O2 => 2 all-trans-retinal"}
{"X":34786,"RHEA_ID":42846,"compounds":"7 CO2 + 7 CoA + 2 H2O + 5 NADP(+) + narbonolide => 6 (S)-methylmalonyl-CoA + 12 H(+) + malonyl-CoA + 5 NADPH"}
{"X":34787,"RHEA_ID":52834,"compounds":"7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+) => 1-hydroxylimonen-2-one + H(+) + NADPH + O2"}
{"X":34788,"RHEA_ID":32891,"DIRECTION":"UN","MASTER_ID":32891,"ec":"1.14.13.155","compounds":"(1S,5S)-alpha-pinene + H(+) + NADH + O2 = alpha-pinene oxide + H2O + NAD(+)"}
{"X":34789,"RHEA_ID":42849,"DIRECTION":"LR","MASTER_ID":42848,"metacyc":"RXN-15406","compounds":"8-demethyltetracenomycin C + dTDP-beta-L-rhamnose => 8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + dTDP + H(+)"}
{"X":34790,"RHEA_ID":42850,"compounds":"8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + dTDP + H(+) => 8-demethyltetracenomycin C + dTDP-beta-L-rhamnose"}
{"X":34791,"RHEA_ID":32894,"compounds":"(1S,5S)-alpha-pinene + H(+) + NADH + O2 <=> alpha-pinene oxide + H2O + NAD(+)"}
{"X":34792,"RHEA_ID":32895,"DIRECTION":"UN","MASTER_ID":32895,"ec":"1.14.14.56","compounds":"1,8-cineole + O2 + reduced [NADPH--hemoprotein reductase] = 2-exo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":34793,"RHEA_ID":42853,"DIRECTION":"LR","MASTER_ID":42852,"metacyc":"RXN-15718","compounds":"3 H(+) + holo-[2-methylbutanoate polyketide synthase] + 2 malonyl-CoA + 2 NADPH + S-adenosyl-L-methionine => (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CO2 + 2 CoA + H2O + 2 NADP(+) + S-adenosyl-L-homocysteine"}
{"X":34794,"RHEA_ID":42854,"compounds":"(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CO2 + 2 CoA + H2O + 2 NADP(+) + S-adenosyl-L-homocysteine => 3 H(+) + holo-[2-methylbutanoate polyketide synthase] + 2 malonyl-CoA + 2 NADPH + S-adenosyl-L-methionine"}
{"X":34795,"RHEA_ID":52842,"compounds":"1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + UDP => 4-hydroxy-3-methoxybenzoate + UDP-alpha-D-glucose"}
{"X":34796,"RHEA_ID":32899,"DIRECTION":"UN","MASTER_ID":32899,"ec":"1.14.14.133","compounds":"1,8-cineole + O2 + reduced [flavodoxin] = 2-endo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [flavodoxin]"}
{"X":34797,"RHEA_ID":32900,"DIRECTION":"LR","MASTER_ID":32899,"metacyc":"RXN-13136","compounds":"1,8-cineole + O2 + reduced [flavodoxin] => 2-endo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [flavodoxin]"}
{"X":34798,"RHEA_ID":42858,"compounds":"1,2-dioctanoyl-sn-glycero-3-phosphate + H(+) + phosphate => 1,2-dioctanoyl-sn-glycero-3-diphosphate + H2O"}
{"X":34799,"RHEA_ID":42859,"compounds":"1,2-dioctanoyl-sn-glycero-3-diphosphate + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phosphate + H(+) + phosphate"}
{"X":34800,"RHEA_ID":32903,"DIRECTION":"UN","MASTER_ID":32903,"ec":"1.14.14.24","compounds":"calciol + O2 + reduced [NADPH--hemoprotein reductase] = calcidiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":34801,"RHEA_ID":42861,"compounds":"1,2-dioctanoyl-sn-glycero-3-phosphate + H2O => 1,2-dioctanoyl-sn-glycerol + phosphate"}
{"X":34802,"RHEA_ID":42862,"compounds":"1,2-dioctanoyl-sn-glycerol + phosphate => 1,2-dioctanoyl-sn-glycero-3-phosphate + H2O"}
{"X":34803,"RHEA_ID":42863,"compounds":"1,2-dioctanoyl-sn-glycero-3-phosphate + H2O <=> 1,2-dioctanoyl-sn-glycerol + phosphate"}
{"X":34804,"RHEA_ID":32907,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + 2 H2O = 2 a carboxylate + 2 H(+) + sn-glycerol 3-phosphocholine"}
{"X":34805,"RHEA_ID":42865,"compounds":"norspermidine + S-adenosyl 3-(methylsulfanyl)propylamine => H(+) + norspermine + S-methyl-5'-thioadenosine"}
{"X":34806,"RHEA_ID":42866,"compounds":"H(+) + norspermine + S-methyl-5'-thioadenosine => norspermidine + S-adenosyl 3-(methylsulfanyl)propylamine"}
{"X":34807,"RHEA_ID":32910,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + 2 H2O <=> 2 a carboxylate + 2 H(+) + sn-glycerol 3-phosphocholine"}
{"X":34808,"RHEA_ID":32911,"compounds":"sn-glycerol 3-phosphocholine(out) = sn-glycerol 3-phosphocholine(in)"}
{"X":34809,"RHEA_ID":32912,"compounds":"sn-glycerol 3-phosphocholine(out) => sn-glycerol 3-phosphocholine(in)"}
{"X":34810,"RHEA_ID":32913,"compounds":"sn-glycerol 3-phosphocholine(in) => sn-glycerol 3-phosphocholine(out)"}
{"X":34811,"RHEA_ID":32914,"compounds":"sn-glycerol 3-phosphocholine(out) <=> sn-glycerol 3-phosphocholine(in)"}
{"X":34812,"RHEA_ID":32915,"compounds":"sn-glycero-3-phospho-1D-myo-inositol(out) = sn-glycero-3-phospho-1D-myo-inositol(in)"}
{"X":34813,"RHEA_ID":42873,"compounds":"N(4)-aminopropylspermidine + S-adenosyl 3-(methylsulfanyl)propylamine => H(+) + N(4)-bis(aminopropyl)spermidine + S-methyl-5'-thioadenosine"}
{"X":34814,"RHEA_ID":42874,"compounds":"H(+) + N(4)-bis(aminopropyl)spermidine + S-methyl-5'-thioadenosine => N(4)-aminopropylspermidine + S-adenosyl 3-(methylsulfanyl)propylamine"}
{"X":34815,"RHEA_ID":32918,"compounds":"sn-glycero-3-phospho-1D-myo-inositol(out) <=> sn-glycero-3-phospho-1D-myo-inositol(in)"}
{"X":34816,"RHEA_ID":32923,"compounds":"H2O + sn-glycero-3-phospho-(1'-sn-glycerol) = glycerol + H(+) + sn-glycerol 3-phosphate"}
{"X":34817,"RHEA_ID":42877,"compounds":"S-adenosyl 3-(methylsulfanyl)propylamine + spermidine => H(+) + N(4)-aminopropylspermidine + S-methyl-5'-thioadenosine"}
{"X":34818,"RHEA_ID":42878,"compounds":"H(+) + N(4)-aminopropylspermidine + S-methyl-5'-thioadenosine => S-adenosyl 3-(methylsulfanyl)propylamine + spermidine"}
{"X":34819,"RHEA_ID":32926,"compounds":"H2O + sn-glycero-3-phospho-(1'-sn-glycerol) <=> glycerol + H(+) + sn-glycerol 3-phosphate"}
{"X":34820,"RHEA_ID":32927,"compounds":"1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = a 1,2-diacyl-sn-glycerol + H(+) + sn-glycerol 3-phosphate"}
{"X":34821,"RHEA_ID":42881,"compounds":"S-adenosyl 3-(methylsulfanyl)propylamine + spermine => H(+) + N(4)-aminopropylspermine + S-methyl-5'-thioadenosine"}
{"X":34822,"RHEA_ID":42882,"compounds":"H(+) + N(4)-aminopropylspermine + S-methyl-5'-thioadenosine => S-adenosyl 3-(methylsulfanyl)propylamine + spermine"}
{"X":34823,"RHEA_ID":32930,"compounds":"1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> a 1,2-diacyl-sn-glycerol + H(+) + sn-glycerol 3-phosphate"}
{"X":34824,"RHEA_ID":32931,"DIRECTION":"UN","MASTER_ID":32931,"ec":"2.7.8.41","compounds":"1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a CDP-1,2-diacyl-sn-glycerol = a cardiolipin + CMP + H(+)"}
{"X":34825,"RHEA_ID":32932,"DIRECTION":"LR","MASTER_ID":32931,"metacyc":"RXN-8141","compounds":"1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a CDP-1,2-diacyl-sn-glycerol => a cardiolipin + CMP + H(+)"}
{"X":34826,"RHEA_ID":52873,"compounds":"17alpha-estradiol + UDP-alpha-D-glucuronate => 17alpha-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":34827,"RHEA_ID":32935,"compounds":"a cardiolipin + H2O = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+)"}
{"X":34828,"RHEA_ID":32936,"compounds":"a cardiolipin + H2O => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+)"}
{"X":34829,"RHEA_ID":52877,"compounds":"16beta,17beta-estriol + UDP-alpha-D-glucuronate => 16beta,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":34830,"RHEA_ID":32938,"compounds":"a cardiolipin + H2O <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+)"}
{"X":34831,"RHEA_ID":32939,"DIRECTION":"UN","MASTER_ID":32939,"ec":"2.7.8.2","compounds":"a 1,2-diacyl-sn-glycerol + CDP-choline = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)"}
{"X":34832,"RHEA_ID":32940,"compounds":"a 1,2-diacyl-sn-glycerol + CDP-choline => a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)"}
{"X":34833,"RHEA_ID":32941,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+) => a 1,2-diacyl-sn-glycerol + CDP-choline"}
{"X":34834,"RHEA_ID":42895,"DIRECTION":"BI","MASTER_ID":42892,"metacyc":"RXN-15568","compounds":"5'-deoxyadenosine + H(+) + H2O <=> 5'-deoxyinosine + NH4(+)"}
{"X":34835,"RHEA_ID":32943,"DIRECTION":"UN","MASTER_ID":32943,"ec":"2.7.8.1","compounds":"a 1,2-diacyl-sn-glycerol + CDP-ethanolamine = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)"}
{"X":34836,"RHEA_ID":32944,"DIRECTION":"LR","MASTER_ID":32943,"metacyc":"ETHANOLAMINEPHOSPHOTRANSFERASE-RXN","compounds":"a 1,2-diacyl-sn-glycerol + CDP-ethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)"}
{"X":34837,"RHEA_ID":42898,"compounds":"H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine => L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine"}
{"X":34838,"RHEA_ID":42899,"compounds":"L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine <=> H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine"}
{"X":34839,"RHEA_ID":42900,"DIRECTION":"UN","MASTER_ID":42900,"ec":"2.1.1.187","compounds":"guanosine(745) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(745) in 23S rRNA + S-adenosyl-L-homocysteine"}
{"X":34840,"RHEA_ID":32948,"compounds":"a 2-acylglycerol + an acyl-CoA => a 1,2-diacyl-sn-glycerol + CoA"}
{"X":34841,"RHEA_ID":42902,"compounds":"H(+) + N(1)-methylguanosine(745) in 23S rRNA + S-adenosyl-L-homocysteine => guanosine(745) in 23S rRNA + S-adenosyl-L-methionine"}
{"X":34842,"RHEA_ID":32951,"DIRECTION":"UN","MASTER_ID":32951,"ec":"5.4.99.11","compounds":"sucrose = trehalulose"}
{"X":34843,"RHEA_ID":32952,"compounds":"sucrose => trehalulose"}
{"X":34844,"RHEA_ID":42906,"compounds":"H(+) + N(1)-methylguanosine(748) in 23S rRNA + S-adenosyl-L-homocysteine => guanosine(748) in 23S rRNA + S-adenosyl-L-methionine"}
{"X":34845,"RHEA_ID":32954,"compounds":"sucrose <=> trehalulose"}
{"X":34846,"RHEA_ID":42908,"DIRECTION":"UN","MASTER_ID":42908,"ec":"2.1.1.190","compounds":"S-adenosyl-L-methionine + uridine(1939) in 23S rRNA = 5-methyluridine(1939) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":34847,"RHEA_ID":32956,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate"}
{"X":34848,"RHEA_ID":32957,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O"}
{"X":34849,"RHEA_ID":32958,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate"}
{"X":34850,"RHEA_ID":36291,"DIRECTION":"UN","MASTER_ID":36291,"ec":"1.14.13.179","compounds":"3-methylxanthine + H(+) + NADPH + O2 = formaldehyde + H2O + NADP(+) + xanthine"}
{"X":34851,"RHEA_ID":32960,"compounds":"H2O + L-isoleucine + NAD(+) => (S)-3-methyl-2-oxopentanoate + H(+) + NADH + NH4(+)"}
{"X":34852,"RHEA_ID":32961,"compounds":"(S)-3-methyl-2-oxopentanoate + H(+) + NADH + NH4(+) => H2O + L-isoleucine + NAD(+)"}
{"X":34853,"RHEA_ID":42915,"compounds":"cytidine(1962) in 23S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(1962) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":34854,"RHEA_ID":36295,"DIRECTION":"UN","MASTER_ID":36295,"ec":"3.1.3.90","compounds":"alpha-maltose 6'-phosphate + H2O = D-maltose + phosphate"}
{"X":34855,"RHEA_ID":32963,"DIRECTION":"UN","MASTER_ID":32963,"ec":"3.5.1.3","compounds":"2-oxoglutaramate + H2O = 2-oxoglutarate + NH4(+)"}
{"X":34856,"RHEA_ID":32964,"DIRECTION":"LR","MASTER_ID":32963,"metacyc":"RXN-13072","compounds":"2-oxoglutaramate + H2O => 2-oxoglutarate + NH4(+)"}
{"X":34857,"RHEA_ID":32965,"compounds":"2-oxoglutarate + NH4(+) => 2-oxoglutaramate + H2O"}
{"X":34858,"RHEA_ID":36299,"compounds":"(E)-caffeate + ATP + CoA = AMP + caffeoyl-CoA + diphosphate"}
{"X":34859,"RHEA_ID":32967,"compounds":"a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O = a fatty acid + H(+) + sn-glycero-3-phosphoethanolamine"}
{"X":34860,"RHEA_ID":32968,"compounds":"a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O => a fatty acid + H(+) + sn-glycero-3-phosphoethanolamine"}
{"X":34861,"RHEA_ID":32969,"compounds":"a fatty acid + H(+) + sn-glycero-3-phosphoethanolamine => a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O"}
{"X":34862,"RHEA_ID":42924,"DIRECTION":"UN","MASTER_ID":42924,"ec":"2.1.1.198","compounds":"cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":34863,"RHEA_ID":32971,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + 2 H2O = 2 a carboxylate + 2 H(+) + sn-glycero-3-phosphoethanolamine"}
{"X":34864,"RHEA_ID":32972,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + 2 H2O => 2 a carboxylate + 2 H(+) + sn-glycero-3-phosphoethanolamine"}
{"X":34865,"RHEA_ID":32973,"compounds":"2 a carboxylate + 2 H(+) + sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + 2 H2O"}
{"X":34866,"RHEA_ID":42928,"DIRECTION":"UN","MASTER_ID":42928,"ec":"2.1.1.199","compounds":"cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine"}
{"X":34867,"RHEA_ID":32975,"compounds":"1,2-diacyl-sn-glycero-3-phospho-L-serine + 2 H2O = 2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-L-serine"}
{"X":34868,"RHEA_ID":32976,"compounds":"1,2-diacyl-sn-glycero-3-phospho-L-serine + 2 H2O => 2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-L-serine"}
{"X":34869,"RHEA_ID":32977,"compounds":"2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-L-serine => 1,2-diacyl-sn-glycero-3-phospho-L-serine + 2 H2O"}
{"X":34870,"RHEA_ID":52919,"compounds":"16alpha,17alpha-estriol + UDP-alpha-D-glucuronate <=> 16alpha,17alpha-estriol 17-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":34871,"RHEA_ID":32979,"DIRECTION":"UN","MASTER_ID":32979,"ec":"3.1.1.111","compounds":"a 1-acyl-sn-glycero-3-phospho-L-serine + H2O = a fatty acid + H(+) + sn-glycero-3-phospho-L-serine"}
{"X":34872,"RHEA_ID":32980,"DIRECTION":"LR","MASTER_ID":32979,"metacyc":"RXN-20544","compounds":"a 1-acyl-sn-glycero-3-phospho-L-serine + H2O => a fatty acid + H(+) + sn-glycero-3-phospho-L-serine"}
{"X":34873,"RHEA_ID":32981,"compounds":"a fatty acid + H(+) + sn-glycero-3-phospho-L-serine => a 1-acyl-sn-glycero-3-phospho-L-serine + H2O"}
{"X":34874,"RHEA_ID":52923,"compounds":"16alpha,17alpha-estriol + UDP-alpha-D-glucuronate <=> 16alpha,17alpha-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":34875,"RHEA_ID":32983,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + 2 H2O = 2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-1D-myo-inositol"}
{"X":34876,"RHEA_ID":32984,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + 2 H2O => 2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-1D-myo-inositol"}
{"X":34877,"RHEA_ID":32985,"compounds":"2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-1D-myo-inositol => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + 2 H2O"}
{"X":34878,"RHEA_ID":42940,"DIRECTION":"UN","MASTER_ID":42940,"ec":"2.1.1.202","compounds":"cytidine(34) in tRNA precursor + S-adenosyl-L-methionine = 5-methylcytidine(34) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine"}
{"X":34879,"RHEA_ID":32987,"compounds":"a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = a carboxylate + H(+) + sn-glycero-3-phospho-1D-myo-inositol"}
{"X":34880,"RHEA_ID":32988,"compounds":"a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => a carboxylate + H(+) + sn-glycero-3-phospho-1D-myo-inositol"}
{"X":34881,"RHEA_ID":32989,"compounds":"a carboxylate + H(+) + sn-glycero-3-phospho-1D-myo-inositol => a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O"}
{"X":34882,"RHEA_ID":36322,"compounds":"2 H(+) + 2 NADPH + octadecanoyl-CoA <=> CoA + 2 NADP(+) + octadecan-1-ol"}
{"X":34883,"RHEA_ID":32991,"compounds":"2 a 1-acyl-sn-glycero-3-phosphocholine = a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine"}
{"X":34884,"RHEA_ID":32992,"compounds":"2 a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine"}
{"X":34885,"RHEA_ID":32993,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine => 2 a 1-acyl-sn-glycero-3-phosphocholine"}
{"X":34886,"RHEA_ID":52939,"compounds":"3-oxobutanoyl-[ACP] + acetyl-[ACP] + H2O <=> (3S)-hydroxy-3-methylglutaryl-[ACP] + H(+) + holo-[ACP]"}
{"X":34887,"RHEA_ID":32995,"DIRECTION":"UN","MASTER_ID":32995,"ec":"2.3.1.n7","compounds":"a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":34888,"RHEA_ID":32996,"compounds":"a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":34889,"RHEA_ID":32997,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA => a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA"}
{"X":34890,"RHEA_ID":46252,"DIRECTION":"UN","MASTER_ID":46252,"ec":"1.14.19.31","compounds":"2 [Fe(II)-cytochrome b5] + a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-containing glycerolipid + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-containing glycerolipid + 2 H2O"}
{"X":34891,"RHEA_ID":32999,"DIRECTION":"UN","MASTER_ID":32999,"ec":"1.14.14.114","compounds":"(+)-amorpha-4,11-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = (+)-artemisinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}
{"X":34892,"RHEA_ID":33000,"DIRECTION":"LR","MASTER_ID":32999,"metacyc":"RXN-13432","compounds":"(+)-amorpha-4,11-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => (+)-artemisinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}
{"X":34893,"RHEA_ID":36333,"compounds":"diphosphate + N(6)-(dimethylallyl)adenosine 5'-triphosphate => ATP + dimethylallyl diphosphate"}
{"X":34894,"RHEA_ID":46256,"DIRECTION":"UN","MASTER_ID":46256,"ec":"1.14.19.31","compounds":"2 [Fe(II)-cytochrome b5] + a (7Z,10Z,13Z,16Z)-docosatetraenoyl-containing glycerolipid + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-containing glycerolipid + 2 H2O"}
{"X":34895,"RHEA_ID":33003,"compounds":"(+)-amorpha-4,11-diene + O2 + reduced [NADPH--hemoprotein reductase] = (+)-artemisinic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":34896,"RHEA_ID":33004,"DIRECTION":"LR","MASTER_ID":33003,"metacyc":"RXN-8050","compounds":"(+)-amorpha-4,11-diene + O2 + reduced [NADPH--hemoprotein reductase] => (+)-artemisinic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":34897,"RHEA_ID":33005,"compounds":"(+)-artemisinic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-amorpha-4,11-diene + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":34898,"RHEA_ID":46260,"DIRECTION":"UN","MASTER_ID":46260,"ec":"1.14.19.30","compounds":"2 [Fe(II)-cytochrome b5] + an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 H(+) + O2 = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-containing glycerolipid + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":34899,"RHEA_ID":33007,"compounds":"(+)-artemisinic alcohol + O2 + reduced [NADPH--hemoprotein reductase] = (+)-artemisinic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":34900,"RHEA_ID":33008,"DIRECTION":"LR","MASTER_ID":33007,"metacyc":"RXN-8051","compounds":"(+)-artemisinic alcohol + O2 + reduced [NADPH--hemoprotein reductase] => (+)-artemisinic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":34901,"RHEA_ID":33009,"compounds":"(+)-artemisinic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (+)-artemisinic alcohol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":34902,"RHEA_ID":46264,"DIRECTION":"UN","MASTER_ID":46264,"ec":"1.14.19.30","compounds":"2 [Fe(II)-cytochrome b5] + an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-containing glycerolipid + 2 H2O"}
{"X":34903,"RHEA_ID":33011,"compounds":"(+)-artemisinic aldehyde + O2 + reduced [NADPH--hemoprotein reductase] = (+)-artemisinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":34904,"RHEA_ID":33012,"DIRECTION":"LR","MASTER_ID":33011,"metacyc":"RXN-12314","compounds":"(+)-artemisinic aldehyde + O2 + reduced [NADPH--hemoprotein reductase] => (+)-artemisinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":34905,"RHEA_ID":33013,"compounds":"(+)-artemisinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-artemisinic aldehyde + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":34906,"RHEA_ID":36346,"compounds":"2-methylsulfanyl-N(6)-(Delta(2)-isopentenyl)adenosine in tRNA + H(+) + NADPH + O2 <=> 2-methylsulfanyl-N(6)-(cis-4-hydroxy-Delta(2)-isopentenyl)adenosine in tRNA + H2O + NADP(+)"}
{"X":34907,"RHEA_ID":33015,"DIRECTION":"UN","MASTER_ID":33015,"ec":"1.14.13.160","compounds":"[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + H(+) + NADPH + O2 = [(2R)-3,3,4-trimethyl-6-oxo-3,6-dihydro-1H-pyran-2-yl]acetyl-CoA + H2O + NADP(+)"}
{"X":34908,"RHEA_ID":33016,"DIRECTION":"LR","MASTER_ID":33015,"metacyc":"R546-RXN","compounds":"[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + H(+) + NADPH + O2 => [(2R)-3,3,4-trimethyl-6-oxo-3,6-dihydro-1H-pyran-2-yl]acetyl-CoA + H2O + NADP(+)"}
{"X":34909,"RHEA_ID":33017,"compounds":"[(2R)-3,3,4-trimethyl-6-oxo-3,6-dihydro-1H-pyran-2-yl]acetyl-CoA + H2O + NADP(+) => [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + H(+) + NADPH + O2"}
{"X":34910,"RHEA_ID":52963,"compounds":"hyocholate + UDP-alpha-D-glucuronate <=> hyocholoyl-24-O-(beta-D-glucuronate) + UDP"}
{"X":34911,"RHEA_ID":33019,"DIRECTION":"UN","MASTER_ID":33019,"ec":"2.3.1.264","compounds":"(3S)-3,6-diaminohexanoate + acetyl-CoA = (3S)-6-acetamido-3-aminohexanoate + CoA + H(+)"}
{"X":34912,"RHEA_ID":33020,"DIRECTION":"LR","MASTER_ID":33019,"metacyc":"RXN-18530","compounds":"(3S)-3,6-diaminohexanoate + acetyl-CoA => (3S)-6-acetamido-3-aminohexanoate + CoA + H(+)"}
{"X":34913,"RHEA_ID":33021,"compounds":"(3S)-6-acetamido-3-aminohexanoate + CoA + H(+) => (3S)-3,6-diaminohexanoate + acetyl-CoA"}
{"X":34914,"RHEA_ID":46276,"DIRECTION":"UN","MASTER_ID":46276,"ec":"4.1.1.101","compounds":"(S)-malate + H(+) = (S)-lactate + CO2"}
{"X":34915,"RHEA_ID":33023,"DIRECTION":"UN","MASTER_ID":33023,"ec":"1.1.1.343","compounds":"6-phospho-D-gluconate + NAD(+) = CO2 + D-ribulose 5-phosphate + NADH"}
{"X":34916,"RHEA_ID":33023,"DIRECTION":"UN","MASTER_ID":33023,"ec":"1.1.1.351","compounds":"6-phospho-D-gluconate + NAD(+) = CO2 + D-ribulose 5-phosphate + NADH"}
{"X":34917,"RHEA_ID":33024,"DIRECTION":"LR","MASTER_ID":33023,"metacyc":"RXN-3341","compounds":"6-phospho-D-gluconate + NAD(+) => CO2 + D-ribulose 5-phosphate + NADH"}
{"X":34918,"RHEA_ID":42979,"DIRECTION":"BI","MASTER_ID":42976,"ecocyc":"RXN-15578","metacyc":"RXN-15578","compounds":"L-tryptophan <=> 2-aminoprop-2-enoate + indole"}
{"X":34919,"RHEA_ID":33025,"compounds":"CO2 + D-ribulose 5-phosphate + NADH => 6-phospho-D-gluconate + NAD(+)"}
{"X":34920,"RHEA_ID":42981,"DIRECTION":"LR","MASTER_ID":42980,"metacyc":"RXN-15579","compounds":"L-tyrosine => 2-aminoprop-2-enoate + phenol"}
{"X":34921,"RHEA_ID":33027,"DIRECTION":"UN","MASTER_ID":33027,"ec":"1.14.15.9","compounds":"4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spheroidene = 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + spheroiden-2-one"}
{"X":34922,"RHEA_ID":33029,"compounds":"3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + spheroiden-2-one => 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spheroidene"}
{"X":34923,"RHEA_ID":42985,"DIRECTION":"LR","MASTER_ID":42984,"metacyc":"RXN-15704","compounds":"(+)-copalyl diphosphate => diphosphate + pimara-8(14),15-diene"}
{"X":34924,"RHEA_ID":33031,"compounds":"D-fructose + H(+) + NADH = D-sorbitol + NAD(+)"}
{"X":34925,"RHEA_ID":36366,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 2 H(+) + 2 NADPH <=> (9Z,12Z)-octadecadien-1-ol + CoA + 2 NADP(+)"}
{"X":34926,"RHEA_ID":33033,"compounds":"D-sorbitol + NAD(+) => D-fructose + H(+) + NADH"}
{"X":34927,"RHEA_ID":42989,"DIRECTION":"LR","MASTER_ID":42988,"metacyc":"RXN-15705","compounds":"all-trans-geranylgeranyl diphosphate => cembrene C + diphosphate"}
{"X":34928,"RHEA_ID":33035,"DIRECTION":"UN","MASTER_ID":33035,"ec":"1.14.15.9","compounds":"2-oxospirilloxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = 2,2'-dioxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":34929,"RHEA_ID":52983,"compounds":"a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] <=> 7-oxoheptanoyl-[ACP] + a fatty aldehyde + H(+) + 2 H2O + oxidized [flavodoxin]"}
{"X":34930,"RHEA_ID":33037,"compounds":"2,2'-dioxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => 2-oxospirilloxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]"}
{"X":34931,"RHEA_ID":52985,"DIRECTION":"LR","MASTER_ID":52984,"metacyc":"RXN-13837","compounds":"7-oxoheptanoyl-[ACP] + H2O + oxidized [flavodoxin] => 6-carboxyhexanoyl-[ACP] + reduced [flavodoxin]"}
{"X":34932,"RHEA_ID":33039,"DIRECTION":"UN","MASTER_ID":33039,"ec":"1.14.15.9","compounds":"4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin = 2-oxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":34933,"RHEA_ID":33040,"DIRECTION":"LR","MASTER_ID":33039,"metacyc":"RXN-11652","compounds":"4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin => 2-oxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":34934,"RHEA_ID":33041,"compounds":"2-oxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin"}
{"X":34935,"RHEA_ID":52989,"DIRECTION":"LR","MASTER_ID":52988,"metacyc":"RXN-13415","compounds":"[deoxyhypusine synthase]-L-lysine + dehydrospermidine => [deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + propane-1,3-diamine"}
{"X":34936,"RHEA_ID":33043,"DIRECTION":"UN","MASTER_ID":33043,"ec":"1.14.13.161","compounds":"(1R,4R)-camphor + H(+) + NADPH + O2 = (+)-6-exo-hydroxycamphor + H2O + NADP(+)"}
{"X":34937,"RHEA_ID":33045,"compounds":"(+)-6-exo-hydroxycamphor + H2O + NADP(+) => (1R,4R)-camphor + H(+) + NADPH + O2"}
{"X":34938,"RHEA_ID":43001,"DIRECTION":"LR","MASTER_ID":43000,"metacyc":"RXN-15708","compounds":"all-trans-geranylgeranyl diphosphate + H2O => (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol + diphosphate"}
{"X":34939,"RHEA_ID":33047,"DIRECTION":"UN","MASTER_ID":33047,"ec":"1.14.15.10","compounds":"(1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin] = (+)-6-endo-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin]"}
{"X":34940,"RHEA_ID":33049,"compounds":"(+)-6-endo-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin] => (1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin]"}
{"X":34941,"RHEA_ID":43005,"DIRECTION":"LR","MASTER_ID":43004,"metacyc":"RXN-15580","compounds":"H(+) + O-carbamoyl-L-serine => 2-aminoprop-2-enoate + CO2 + NH4(+)"}
{"X":34942,"RHEA_ID":33051,"compounds":"choline + NAD(+) = betaine aldehyde + H(+) + NADH"}
{"X":34943,"RHEA_ID":43007,"compounds":"H(+) + O-carbamoyl-L-serine <=> 2-aminoprop-2-enoate + CO2 + NH4(+)"}
{"X":34944,"RHEA_ID":33053,"compounds":"betaine aldehyde + H(+) + NADH => choline + NAD(+)"}
{"X":34945,"RHEA_ID":43009,"DIRECTION":"LR","MASTER_ID":43008,"ecocyc":"RXN-15581","metacyc":"RXN-15581","compounds":"D-serine => 2-aminoprop-2-enoate + H2O"}
{"X":34946,"RHEA_ID":33055,"DIRECTION":"UN","MASTER_ID":33055,"ec":"3.1.7.2","compounds":"guanosine 3'-diphosphate 5'-triphosphate + H2O = diphosphate + GTP + H(+)"}
{"X":34947,"RHEA_ID":43011,"compounds":"D-serine <=> 2-aminoprop-2-enoate + H2O"}
{"X":34948,"RHEA_ID":33057,"compounds":"diphosphate + GTP + H(+) => guanosine 3'-diphosphate 5'-triphosphate + H2O"}
{"X":34949,"RHEA_ID":43013,"DIRECTION":"LR","MASTER_ID":43012,"metacyc":"RXN-15148","compounds":"L-homocysteine => 2-aminobut-2-enoate + H(+) + hydrogen sulfide"}
{"X":34950,"RHEA_ID":33059,"DIRECTION":"UN","MASTER_ID":33059,"ec":"1.8.1.4","compounds":"(R)-dihydrolipoamide + NAD(+) = (R)-lipoamide + H(+) + NADH"}
{"X":34951,"RHEA_ID":53007,"compounds":"2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate <=> 2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":34952,"RHEA_ID":33061,"compounds":"(R)-lipoamide + H(+) + NADH => (R)-dihydrolipoamide + NAD(+)"}
{"X":34953,"RHEA_ID":53009,"compounds":"(2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate => di-trans,poly-cis-polyprenyl diphosphate + n diphosphate"}
{"X":34954,"RHEA_ID":33063,"DIRECTION":"UN","MASTER_ID":33063,"ec":"1.18.1.5","compounds":"H(+) + NAD(+) + 2 reduced [2Fe-2S]-[putidaredoxin] = NADH + 2 oxidized [2Fe-2S]-[putidaredoxin]"}
{"X":34955,"RHEA_ID":43019,"compounds":"an S-alkyl-L-cysteine <=> 2-aminoprop-2-enoate + an alkyl thiol"}
{"X":34956,"RHEA_ID":33065,"compounds":"NADH + 2 oxidized [2Fe-2S]-[putidaredoxin] => H(+) + NAD(+) + 2 reduced [2Fe-2S]-[putidaredoxin]"}
{"X":34957,"RHEA_ID":43021,"DIRECTION":"LR","MASTER_ID":43020,"ecocyc":"RXN-15131","metacyc":"RXN-15131","compounds":"L,L-cystathionine => 2-aminoprop-2-enoate + L-homocysteine"}
{"X":34958,"RHEA_ID":33067,"compounds":"4-hydroxysphinganine 1-phosphate + H2O = 4-hydroxysphinganine + phosphate"}
{"X":34959,"RHEA_ID":33068,"compounds":"4-hydroxysphinganine 1-phosphate + H2O => 4-hydroxysphinganine + phosphate"}
{"X":34960,"RHEA_ID":43024,"compounds":"an S-substituted L-cysteine = 2-aminoprop-2-enoate + a thiol"}
{"X":34961,"RHEA_ID":43025,"DIRECTION":"LR","MASTER_ID":43024,"metacyc":"RXN-15582","compounds":"an S-substituted L-cysteine => 2-aminoprop-2-enoate + a thiol"}
{"X":34962,"RHEA_ID":33071,"DIRECTION":"UN","MASTER_ID":33071,"ec":"4.2.3.124","compounds":"D-glucose 6-phosphate = 2-deoxy-L-scyllo-inosose + phosphate"}
{"X":34963,"RHEA_ID":33072,"DIRECTION":"LR","MASTER_ID":33071,"metacyc":"RXN-13116","compounds":"D-glucose 6-phosphate => 2-deoxy-L-scyllo-inosose + phosphate"}
{"X":34964,"RHEA_ID":33073,"compounds":"2-deoxy-L-scyllo-inosose + phosphate => D-glucose 6-phosphate"}
{"X":34965,"RHEA_ID":53021,"compounds":"a plastoquinone + an L-alpha-amino acid + H2O => a 2-oxocarboxylate + a plastoquinol + NH4(+)"}
{"X":34966,"RHEA_ID":33075,"DIRECTION":"UN","MASTER_ID":33075,"ec":"2.5.1.120","compounds":"3-[(1-carboxyvinyl)-oxy]benzoate + H2O + S-adenosyl-L-methionine = 6-amino-6-deoxyfutalosine + H(+) + hydrogencarbonate + L-methionine"}
{"X":34967,"RHEA_ID":33076,"DIRECTION":"LR","MASTER_ID":33075,"metacyc":"RXN-15264","compounds":"3-[(1-carboxyvinyl)-oxy]benzoate + H2O + S-adenosyl-L-methionine => 6-amino-6-deoxyfutalosine + H(+) + hydrogencarbonate + L-methionine"}
{"X":34968,"RHEA_ID":43032,"compounds":"3-chloro-D-alanine = 2-aminoprop-2-enoate + chloride + H(+)"}
{"X":34969,"RHEA_ID":53025,"compounds":"a plastoquinone + H2O + L-arginine => 5-guanidino-2-oxopentanoate + a plastoquinol + NH4(+)"}
{"X":34970,"RHEA_ID":33079,"DIRECTION":"UN","MASTER_ID":33079,"ec":"3.2.2.30","compounds":"6-amino-6-deoxyfutalosine + H2O = adenine + dehypoxanthine futalosine"}
{"X":34971,"RHEA_ID":33080,"DIRECTION":"LR","MASTER_ID":33079,"metacyc":"RXN-12346","compounds":"6-amino-6-deoxyfutalosine + H2O => adenine + dehypoxanthine futalosine"}
{"X":34972,"RHEA_ID":33081,"compounds":"adenine + dehypoxanthine futalosine => 6-amino-6-deoxyfutalosine + H2O"}
{"X":34973,"RHEA_ID":53029,"compounds":"lithocholate + UDP-alpha-D-glucuronate => H(+) + lithocholoyl-3-O-(beta-D-glucuronate) + UDP"}
{"X":34974,"RHEA_ID":33083,"DIRECTION":"UN","MASTER_ID":33083,"ec":"1.21.98.1","compounds":"dehypoxanthine futalosine + S-adenosyl-L-methionine = 5'-deoxyadenosine + cyclic dehypoxanthinylfutalosinate + H(+) + L-methionine"}
{"X":34975,"RHEA_ID":33084,"DIRECTION":"LR","MASTER_ID":33083,"metacyc":"RXN-10620","compounds":"dehypoxanthine futalosine + S-adenosyl-L-methionine => 5'-deoxyadenosine + cyclic dehypoxanthinylfutalosinate + H(+) + L-methionine"}
{"X":34976,"RHEA_ID":43040,"compounds":"hexadecanoyl-CoA + hexadecasphinganine = CoA + H(+) + N-hexadecanoylhexadecasphinganine"}
{"X":34977,"RHEA_ID":43041,"compounds":"hexadecanoyl-CoA + hexadecasphinganine => CoA + H(+) + N-hexadecanoylhexadecasphinganine"}
{"X":34978,"RHEA_ID":33087,"compounds":"cyclic dehypoxanthinylfutalosinate = 1,4-dihydroxy-6-naphthoate + chemical entity"}
{"X":34979,"RHEA_ID":33088,"DIRECTION":"LR","MASTER_ID":33087,"metacyc":"RXN-10622","compounds":"cyclic dehypoxanthinylfutalosinate => 1,4-dihydroxy-6-naphthoate + chemical entity"}
{"X":34980,"RHEA_ID":43044,"compounds":"hexadecasphinganine + octadecanoyl-CoA = CoA + H(+) + N-octadecanoylhexadecasphinganine"}
{"X":34981,"RHEA_ID":43045,"compounds":"hexadecasphinganine + octadecanoyl-CoA => CoA + H(+) + N-octadecanoylhexadecasphinganine"}
{"X":34982,"RHEA_ID":33091,"compounds":"1,4-dihydroxy-6-naphthoate + all-trans-octaprenyl diphosphate + H(+) = 2-demethylmenaquinol-8 + CO2 + diphosphate"}
{"X":34983,"RHEA_ID":33092,"DIRECTION":"LR","MASTER_ID":33091,"metacyc":"RXN-10623","compounds":"1,4-dihydroxy-6-naphthoate + all-trans-octaprenyl diphosphate + H(+) => 2-demethylmenaquinol-8 + CO2 + diphosphate"}
{"X":34984,"RHEA_ID":33093,"compounds":"2-demethylmenaquinol-8 + CO2 + diphosphate => 1,4-dihydroxy-6-naphthoate + all-trans-octaprenyl diphosphate + H(+)"}
{"X":34985,"RHEA_ID":43049,"compounds":"keto-D-tagatose => keto-D-sorbose"}
{"X":34986,"RHEA_ID":33095,"compounds":"chorismate + inosine + phosphoenolpyruvate = futalosine"}
{"X":34987,"RHEA_ID":33096,"compounds":"chorismate + inosine + phosphoenolpyruvate => futalosine"}
{"X":34988,"RHEA_ID":33097,"compounds":"futalosine => chorismate + inosine + phosphoenolpyruvate"}
{"X":34989,"RHEA_ID":33098,"compounds":"chorismate + inosine + phosphoenolpyruvate <=> futalosine"}
{"X":34990,"RHEA_ID":33099,"DIRECTION":"UN","MASTER_ID":33099,"ec":"2.3.1.57","compounds":"acetyl-CoA + spermine = CoA + H(+) + N(1)-acetylspermine"}
{"X":34991,"RHEA_ID":33100,"DIRECTION":"LR","MASTER_ID":33099,"metacyc":"RXN-9939","reactome":"R-HSA-351207.1","compounds":"acetyl-CoA + spermine => CoA + H(+) + N(1)-acetylspermine"}
{"X":34992,"RHEA_ID":43056,"DIRECTION":"UN","MASTER_ID":43056,"ec":"2.3.1.239","compounds":"5 (S)-methylmalonyl-CoA + 11 H(+) + malonyl-CoA + 5 NADPH = 10-deoxymethynolide + 6 CO2 + 6 CoA + 2 H2O + 5 NADP(+)"}
{"X":34993,"RHEA_ID":33102,"compounds":"acetyl-CoA + spermine <=> CoA + H(+) + N(1)-acetylspermine"}
{"X":34994,"RHEA_ID":33103,"DIRECTION":"UN","MASTER_ID":33103,"ec":"4.2.3.125","compounds":"(2E,6E)-farnesyl diphosphate = alpha-muurolene + diphosphate"}
{"X":34995,"RHEA_ID":33104,"DIRECTION":"LR","MASTER_ID":33103,"metacyc":"RXN-8599","compounds":"(2E,6E)-farnesyl diphosphate => alpha-muurolene + diphosphate"}
{"X":34996,"RHEA_ID":43060,"DIRECTION":"UN","MASTER_ID":43060,"ec":"2.4.1.332","compounds":"2-O-(alpha-D-glucopyranosyl)glycerol + phosphate = beta-D-glucose 1-phosphate + glycerol"}
{"X":34997,"RHEA_ID":53053,"compounds":"4-hydroxyestrone + UDP-alpha-D-glucuronate => 4-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":34998,"RHEA_ID":33107,"DIRECTION":"UN","MASTER_ID":33107,"ec":"4.2.3.126","compounds":"(2E,6E)-farnesyl diphosphate = diphosphate + gamma-muurolene"}
{"X":34999,"RHEA_ID":33108,"DIRECTION":"LR","MASTER_ID":33107,"metacyc":"RXN-8592","compounds":"(2E,6E)-farnesyl diphosphate => diphosphate + gamma-muurolene"}
{"X":35000,"RHEA_ID":43064,"DIRECTION":"UN","MASTER_ID":43064,"ec":"2.3.1.238","compounds":"(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + monacolin J carboxylate = holo-[2-methylbutanoate polyketide synthase] + lovastatin carboxylate"}
{"X":35001,"RHEA_ID":53057,"DIRECTION":"LR","MASTER_ID":53056,"metacyc":"RXN-14526","compounds":"4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine => H(+) + isowyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine"}
{"X":35002,"RHEA_ID":33111,"DIRECTION":"UN","MASTER_ID":33111,"ec":"4.2.3.127","compounds":"(2E,6E)-farnesyl diphosphate = beta-copaene + diphosphate"}
{"X":35003,"RHEA_ID":33112,"DIRECTION":"LR","MASTER_ID":33111,"metacyc":"RXN-8551","compounds":"(2E,6E)-farnesyl diphosphate => beta-copaene + diphosphate"}
{"X":35004,"RHEA_ID":43068,"DIRECTION":"UN","MASTER_ID":43068,"ec":"1.14.14.126","compounds":"beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 4 H(+) + 4 H2O + oleanolate + 3 oxidized [NADPH--hemoprotein reductase]"}
{"X":35005,"RHEA_ID":53061,"compounds":"4-hydroxyestrone + UDP-alpha-D-glucuronate => estrone 4-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":35006,"RHEA_ID":33115,"compounds":"malonate(in) = malonate(out)"}
{"X":35007,"RHEA_ID":33116,"compounds":"malonate(in) => malonate(out)"}
{"X":35008,"RHEA_ID":43072,"compounds":"beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = erythrodiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":35009,"RHEA_ID":33118,"compounds":"malonate(in) <=> malonate(out)"}
{"X":35010,"RHEA_ID":33119,"DIRECTION":"UN","MASTER_ID":33119,"ec":"4.2.3.129","compounds":"(2E,6E)-farnesyl diphosphate = (+)-sativene + diphosphate"}
{"X":35011,"RHEA_ID":33120,"DIRECTION":"LR","MASTER_ID":33119,"metacyc":"RXN-8601","compounds":"(2E,6E)-farnesyl diphosphate => (+)-sativene + diphosphate"}
{"X":35012,"RHEA_ID":43076,"compounds":"erythrodiol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oleanolic aldehyde + oxidized [NADPH--hemoprotein reductase]"}
{"X":35013,"RHEA_ID":53069,"compounds":"4-methoxyestrone + UDP-alpha-D-glucuronate => 4-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":35014,"RHEA_ID":33123,"DIRECTION":"UN","MASTER_ID":33123,"ec":"4.2.3.130","compounds":"all-trans-heptaprenyl diphosphate = diphosphate + tetraprenyl-beta-curcumene"}
{"X":35015,"RHEA_ID":33124,"DIRECTION":"LR","MASTER_ID":33123,"metacyc":"RXN-13337","compounds":"all-trans-heptaprenyl diphosphate => diphosphate + tetraprenyl-beta-curcumene"}
{"X":35016,"RHEA_ID":33125,"compounds":"diphosphate + tetraprenyl-beta-curcumene => all-trans-heptaprenyl diphosphate"}
{"X":35017,"RHEA_ID":43081,"DIRECTION":"LR","MASTER_ID":43080,"metacyc":"RXN-13505","compounds":"O2 + oleanolic aldehyde + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + oleanolate + oxidized [NADPH--hemoprotein reductase]"}
{"X":35018,"RHEA_ID":33127,"compounds":"H2O + salicin-6-phosphate = beta-D-glucose 6-phosphate + salicyl alcohol"}
{"X":35019,"RHEA_ID":33128,"DIRECTION":"LR","MASTER_ID":33127,"metacyc":"RXN0-5297","compounds":"H2O + salicin-6-phosphate => beta-D-glucose 6-phosphate + salicyl alcohol"}
{"X":35020,"RHEA_ID":43084,"DIRECTION":"UN","MASTER_ID":43084,"ec":"2.1.1.207","compounds":"cytidine(34) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":35021,"RHEA_ID":53077,"compounds":"cytidine(34) in mitochondrial tRNA + S-adenosyl-L-methionine => 5-methylcytidine(34) in mitochondrial tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":35022,"RHEA_ID":33131,"compounds":"L-phenylalanine + tetrahydro-4-hydroxyphenylpyruvate = 3-phenylpyruvate + tetrahydrotyrosine"}
{"X":35023,"RHEA_ID":33132,"compounds":"L-phenylalanine + tetrahydro-4-hydroxyphenylpyruvate => 3-phenylpyruvate + tetrahydrotyrosine"}
{"X":35024,"RHEA_ID":43088,"DIRECTION":"UN","MASTER_ID":43088,"ec":"2.1.1.207","compounds":"5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine = 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine"}
{"X":35025,"RHEA_ID":43089,"DIRECTION":"LR","MASTER_ID":43088,"ecocyc":"RXN-11865","metacyc":"RXN-11865","compounds":"5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine => 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine"}
{"X":35026,"RHEA_ID":33135,"compounds":"malonate(in) + Na(+)(in) = malonate(out) + Na(+)(out)"}
{"X":35027,"RHEA_ID":33136,"compounds":"malonate(in) + Na(+)(in) => malonate(out) + Na(+)(out)"}
{"X":35028,"RHEA_ID":43092,"DIRECTION":"UN","MASTER_ID":43092,"ec":"2.1.1.208","compounds":"S-adenosyl-L-methionine + uridine(2479) in 23S rRNA = 2'-O-methyluridine(2479) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":35029,"RHEA_ID":33138,"compounds":"malonate(in) + Na(+)(in) <=> malonate(out) + Na(+)(out)"}
{"X":35030,"RHEA_ID":33139,"compounds":"L-alanine(out) + L-aspartate(in) = L-alanine(in) + L-aspartate(out)"}
{"X":35031,"RHEA_ID":33140,"compounds":"L-alanine(out) + L-aspartate(in) => L-alanine(in) + L-aspartate(out)"}
{"X":35032,"RHEA_ID":43096,"DIRECTION":"UN","MASTER_ID":43096,"ec":"2.1.1.209","compounds":"guanosine(2535) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(2535) in 23S rRNA + S-adenosyl-L-homocysteine"}
{"X":35033,"RHEA_ID":43097,"DIRECTION":"LR","MASTER_ID":43096,"metacyc":"RXN-12228","compounds":"guanosine(2535) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylguanosine(2535) in 23S rRNA + S-adenosyl-L-homocysteine"}
{"X":35034,"RHEA_ID":33143,"compounds":"galactitol(in) = galactitol(out)"}
{"X":35035,"RHEA_ID":33144,"compounds":"galactitol(in) => galactitol(out)"}
{"X":35036,"RHEA_ID":43100,"DIRECTION":"UN","MASTER_ID":43100,"ec":"2.1.1.211","compounds":"S-adenosyl-L-methionine + uridine(44) in tRNA(Ser) = 2'-O-methyluridine(44) in tRNA(Ser) + H(+) + S-adenosyl-L-homocysteine"}
{"X":35037,"RHEA_ID":43101,"DIRECTION":"LR","MASTER_ID":43100,"metacyc":"RXN-12368","compounds":"S-adenosyl-L-methionine + uridine(44) in tRNA(Ser) => 2'-O-methyluridine(44) in tRNA(Ser) + H(+) + S-adenosyl-L-homocysteine"}
{"X":35038,"RHEA_ID":33147,"DIRECTION":"UN","MASTER_ID":33147,"ec":"7.6.2.2","compounds":"ATP + daunorubicin(in) + H2O = ADP + daunorubicin(out) + H(+) + phosphate"}
{"X":35039,"RHEA_ID":33148,"compounds":"ATP + daunorubicin(in) + H2O => ADP + daunorubicin(out) + H(+) + phosphate"}
{"X":35040,"RHEA_ID":43104,"compounds":"AH2 + N-acyleicosasphinganine + O2 = A + 2 H2O + N-acyleicosasphing-4-enine"}
{"X":35041,"RHEA_ID":43105,"compounds":"AH2 + N-acyleicosasphinganine + O2 => A + 2 H2O + N-acyleicosasphing-4-enine"}
{"X":35042,"RHEA_ID":33151,"DIRECTION":"UN","MASTER_ID":33151,"ec":"2.3.1.12","compounds":"(R)-dihydrolipoamide + acetyl-CoA = (R)-S(6)-acetyldihydrolipoamide + CoA"}
{"X":35043,"RHEA_ID":33152,"compounds":"(R)-dihydrolipoamide + acetyl-CoA => (R)-S(6)-acetyldihydrolipoamide + CoA"}
{"X":35044,"RHEA_ID":43108,"DIRECTION":"UN","MASTER_ID":43108,"ec":"1.7.2.4","compounds":"2 [Fe(III)cytochrome c] + H2O + N2 = 2 [Fe(II)cytochrome c] + 2 H(+) + nitrous oxide"}
{"X":35045,"RHEA_ID":43109,"compounds":"2 [Fe(III)cytochrome c] + H2O + N2 => 2 [Fe(II)cytochrome c] + 2 H(+) + nitrous oxide"}
{"X":35046,"RHEA_ID":33155,"DIRECTION":"UN","MASTER_ID":33155,"ec":"3.1.3.106","compounds":"a 1-acyl-sn-glycero-3-phosphate + H2O = a 1-acyl-sn-glycerol + phosphate"}
{"X":35047,"RHEA_ID":33156,"compounds":"a 1-acyl-sn-glycero-3-phosphate + H2O => a 1-acyl-sn-glycerol + phosphate"}
{"X":35048,"RHEA_ID":43112,"DIRECTION":"UN","MASTER_ID":43112,"ec":"1.1.1.379","compounds":"(R)-mandelate + NAD(+) = H(+) + NADH + phenylglyoxylate"}
{"X":35049,"RHEA_ID":33158,"compounds":"a 1-acyl-sn-glycero-3-phosphate + H2O <=> a 1-acyl-sn-glycerol + phosphate"}
{"X":35050,"RHEA_ID":33159,"DIRECTION":"UN","MASTER_ID":33159,"ec":"3.1.4.54","compounds":"H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 1,2-diacyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)"}
{"X":35051,"RHEA_ID":33160,"DIRECTION":"LR","MASTER_ID":33159,"metacyc":"RXN-12116","compounds":"H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)"}
{"X":35052,"RHEA_ID":43116,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + N-octanoylsphinganine + O2 = 2 [Fe(III)-cytochrome b5] + H2O + N-octanoyl-4-hydroxysphinganine"}
{"X":35053,"RHEA_ID":33162,"compounds":"H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a 1,2-diacyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)"}
{"X":35054,"RHEA_ID":33163,"compounds":"beta-nicotinamide D-riboside(in) = beta-nicotinamide D-riboside(out)"}
{"X":35055,"RHEA_ID":43119,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + N-octanoylsphinganine + O2 <=> 2 [Fe(III)-cytochrome b5] + H2O + N-octanoyl-4-hydroxysphinganine"}
{"X":35056,"RHEA_ID":33165,"compounds":"beta-nicotinamide D-riboside(out) => beta-nicotinamide D-riboside(in)"}
{"X":35057,"RHEA_ID":43121,"DIRECTION":"LR","MASTER_ID":43120,"metacyc":"RXN-15841","compounds":"2-oxoglutarate + O2 + xanthine => CO2 + succinate + urate"}
{"X":35058,"RHEA_ID":33167,"compounds":"2 a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycero-3-phospho-1D-myo-inositol"}
{"X":35059,"RHEA_ID":53115,"compounds":"3alpha-hydroxy-5alpha-androstane 17-O-(beta-D-glucuronate) + NADP(+) <=> 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + NADPH"}
{"X":35060,"RHEA_ID":33169,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycero-3-phospho-1D-myo-inositol => 2 a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol)"}
{"X":35061,"RHEA_ID":33170,"compounds":"2 a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycero-3-phospho-1D-myo-inositol"}
{"X":35062,"RHEA_ID":33171,"compounds":"D-maltose(in) = D-maltose(out)"}
{"X":35063,"RHEA_ID":33172,"compounds":"D-maltose(in) => D-maltose(out)"}
{"X":35064,"RHEA_ID":33173,"compounds":"D-maltose(out) => D-maltose(in)"}
{"X":35065,"RHEA_ID":43129,"DIRECTION":"LR","MASTER_ID":43128,"metacyc":"RXN-12369","compounds":"guanosine(10) in tRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-homocysteine"}
{"X":35066,"RHEA_ID":33175,"compounds":"4-hydroxyphenylacetate(in) = 4-hydroxyphenylacetate(out)"}
{"X":35067,"RHEA_ID":43131,"compounds":"guanosine(10) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-homocysteine"}
{"X":35068,"RHEA_ID":33177,"compounds":"4-hydroxyphenylacetate(out) => 4-hydroxyphenylacetate(in)"}
{"X":35069,"RHEA_ID":33178,"compounds":"4-hydroxyphenylacetate(in) <=> 4-hydroxyphenylacetate(out)"}
{"X":35070,"RHEA_ID":33179,"DIRECTION":"UN","MASTER_ID":33179,"ec":"3.1.4.11","compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)"}
{"X":35071,"RHEA_ID":43135,"compounds":"N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-dimethylguanosine(10) in tRNA + S-adenosyl-L-homocysteine"}
{"X":35072,"RHEA_ID":33181,"compounds":"1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O"}
{"X":35073,"RHEA_ID":43137,"DIRECTION":"LR","MASTER_ID":43136,"metacyc":"RXN-12380","compounds":"guanosine(26)/guanosine(27) in tRNA + 4 S-adenosyl-L-methionine => 4 H(+) + N(2)-dimethylguanosine(26)/N(2)-dimethylguanosine(27) in tRNA + 4 S-adenosyl-L-homocysteine"}
{"X":35074,"RHEA_ID":33183,"compounds":"citrate(in) = citrate(out)"}
{"X":35075,"RHEA_ID":33184,"compounds":"citrate(in) => citrate(out)"}
{"X":35076,"RHEA_ID":33185,"compounds":"citrate(out) => citrate(in)"}
{"X":35077,"RHEA_ID":43141,"DIRECTION":"LR","MASTER_ID":43140,"metacyc":"RXN-12376","compounds":"guanosine(26) in tRNA + 2 S-adenosyl-L-methionine => 2 H(+) + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine"}
{"X":35078,"RHEA_ID":33187,"compounds":"(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":35079,"RHEA_ID":43143,"compounds":"guanosine(26) in tRNA + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine"}
{"X":35080,"RHEA_ID":33189,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate"}
{"X":35081,"RHEA_ID":43145,"DIRECTION":"LR","MASTER_ID":43144,"metacyc":"RXN-12472","compounds":"adenosine(22) in tRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyladenosine(22) in tRNA + S-adenosyl-L-homocysteine"}
{"X":35082,"RHEA_ID":33191,"DIRECTION":"UN","MASTER_ID":33191,"ec":"2.3.1.n6","compounds":"a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA = 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA"}
{"X":35083,"RHEA_ID":43147,"compounds":"adenosine(22) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyladenosine(22) in tRNA + S-adenosyl-L-homocysteine"}
{"X":35084,"RHEA_ID":33193,"compounds":"1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA => a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA"}
{"X":35085,"RHEA_ID":43149,"DIRECTION":"LR","MASTER_ID":43148,"metacyc":"RXN-12471","compounds":"adenosine(9) in tRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyladenosine(9) in tRNA + S-adenosyl-L-homocysteine"}
{"X":35086,"RHEA_ID":33195,"compounds":"a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}
{"X":35087,"RHEA_ID":43151,"compounds":"adenosine(9) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyladenosine(9) in tRNA + S-adenosyl-L-homocysteine"}
{"X":35088,"RHEA_ID":33197,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA"}
{"X":35089,"RHEA_ID":43153,"DIRECTION":"LR","MASTER_ID":43152,"metacyc":"RXN-12466","compounds":"adenosine(58) in tRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine"}
{"X":35090,"RHEA_ID":33199,"compounds":"butan-1-ol + NAD(+) = butanal + H(+) + NADH"}
{"X":35091,"RHEA_ID":43155,"compounds":"adenosine(58) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine"}
{"X":35092,"RHEA_ID":33201,"compounds":"butanal + H(+) + NADH => butan-1-ol + NAD(+)"}
{"X":35093,"RHEA_ID":43157,"DIRECTION":"LR","MASTER_ID":43156,"metacyc":"RXN-12459","compounds":"guanosine(9) in tRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine"}
{"X":35094,"RHEA_ID":33203,"compounds":"1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":35095,"RHEA_ID":43159,"compounds":"guanosine(9) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine"}
{"X":35096,"RHEA_ID":33205,"compounds":"1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA"}
{"X":35097,"RHEA_ID":33206,"compounds":"1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":35098,"RHEA_ID":33207,"compounds":"ATP + H(+) + L-glutamate + NADPH = ADP + L-glutamate 5-semialdehyde + NADP(+) + phosphate"}
{"X":35099,"RHEA_ID":43163,"compounds":"adenosine(37) in tRNA1(Val) + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine(37) in tRNA1(Val) + S-adenosyl-L-homocysteine"}
{"X":35100,"RHEA_ID":33209,"compounds":"ADP + L-glutamate 5-semialdehyde + NADP(+) + phosphate => ATP + H(+) + L-glutamate + NADPH"}
{"X":35101,"RHEA_ID":33210,"compounds":"ATP + H(+) + L-glutamate + NADPH <=> ADP + L-glutamate 5-semialdehyde + NADP(+) + phosphate"}
{"X":35102,"RHEA_ID":33211,"DIRECTION":"UN","MASTER_ID":33211,"ec":"2.5.1.74","compounds":"1,4-dihydroxy-2-naphthoate + all-trans-heptaprenyl diphosphate + H(+) = 2-demethylmenaquinol-7 + CO2 + diphosphate"}
{"X":35103,"RHEA_ID":43167,"compounds":"7-cyano-7-deazaguanine + guanosine(15) in tRNA <=> 7-cyano-7-carbaguanosine(15) in tRNA + guanine"}
{"X":35104,"RHEA_ID":33213,"compounds":"2-demethylmenaquinol-7 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-heptaprenyl diphosphate + H(+)"}
{"X":35105,"RHEA_ID":33214,"compounds":"1,4-dihydroxy-2-naphthoate + all-trans-heptaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-7 + CO2 + diphosphate"}
{"X":35106,"RHEA_ID":43170,"compounds":"inosine(34) in tRNA + NH4(+) => adenosine(34) in tRNA + H(+) + H2O"}
{"X":35107,"RHEA_ID":33217,"compounds":"all-trans-heptaprenyl diphosphate + 3 diphosphate => all-trans-geranylgeranyl diphosphate + 3 isopentenyl diphosphate"}
{"X":35108,"RHEA_ID":33218,"DIRECTION":"BI","MASTER_ID":33215,"metacyc":"RXN-11458","compounds":"all-trans-geranylgeranyl diphosphate + 3 isopentenyl diphosphate <=> all-trans-heptaprenyl diphosphate + 3 diphosphate"}
{"X":35109,"RHEA_ID":43174,"compounds":"N(7)-methylguanosine(1575) in yeast 18S rRNA + S-adenosyl-L-homocysteine => guanosine(1575) in yeast 18S rRNA + S-adenosyl-L-methionine"}
{"X":35110,"RHEA_ID":33220,"DIRECTION":"LR","MASTER_ID":33219,"metacyc":"RXN-13189","compounds":"ent-kaur-16-en-19-oate + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => gibberellin A12 + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}
{"X":35111,"RHEA_ID":33221,"compounds":"gibberellin A12 + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-oate + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]"}
{"X":35112,"RHEA_ID":43177,"DIRECTION":"LR","MASTER_ID":43176,"metacyc":"RXN-15843","compounds":"cytidine(2870) in 25S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(2870) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":35113,"RHEA_ID":43178,"compounds":"5-methylcytidine(2870) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(2870) in 25S rRNA + S-adenosyl-L-methionine"}
{"X":35114,"RHEA_ID":43179,"compounds":"cytidine(2870) in 25S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(2870) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":35115,"RHEA_ID":33225,"compounds":"CO2 + NADH + propanoyl-CoA => 2-oxobutanoate + CoA + NAD(+)"}
{"X":35116,"RHEA_ID":33226,"compounds":"2-oxobutanoate + CoA + NAD(+) <=> CO2 + NADH + propanoyl-CoA"}
{"X":35117,"RHEA_ID":43182,"compounds":"5-methylcytidine(2278) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(2278) in 25S rRNA + S-adenosyl-L-methionine"}
{"X":35118,"RHEA_ID":43183,"compounds":"cytidine(2278) in 25S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(2278) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":35119,"RHEA_ID":33229,"compounds":"4-hydroxystyrene + CO2 => H(+) + trans-4-coumarate"}
{"X":35120,"RHEA_ID":43185,"compounds":"S-adenosyl-L-methionine + uridine(2843) in 25S rRNA => H(+) + N(3)-methyluridine(2843) in 25S rRNA + S-adenosyl-L-homocysteine"}
{"X":35121,"RHEA_ID":43186,"compounds":"H(+) + N(3)-methyluridine(2843) in 25S rRNA + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(2843) in 25S rRNA"}
{"X":35122,"RHEA_ID":33232,"compounds":"H2O2 + heme b => heme d cis-diol"}
{"X":35123,"RHEA_ID":33233,"compounds":"heme d cis-diol => H2O2 + heme b"}
{"X":35124,"RHEA_ID":43189,"DIRECTION":"LR","MASTER_ID":43188,"metacyc":"RXN-15846","compounds":"S-adenosyl-L-methionine + uridine(2634) in 25S rRNA => H(+) + N(3)-methyluridine(2634) in 25S rRNA + S-adenosyl-L-homocysteine"}
{"X":35125,"RHEA_ID":43190,"compounds":"H(+) + N(3)-methyluridine(2634) in 25S rRNA + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(2634) in 25S rRNA"}
{"X":35126,"RHEA_ID":33236,"DIRECTION":"LR","MASTER_ID":33235,"metacyc":"RXN-13191","compounds":"2 H(+) + Mg-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 O2 => 3,8-divinyl protochlorophyllide a + 5 H2O + 3 NADP(+)"}
{"X":35127,"RHEA_ID":33237,"compounds":"3,8-divinyl protochlorophyllide a + 5 H2O + 3 NADP(+) => 2 H(+) + Mg-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 O2"}
{"X":35128,"RHEA_ID":53185,"compounds":"1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H2O => 1-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}
{"X":35129,"RHEA_ID":43194,"compounds":"2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + H(+) + S-adenosyl-L-homocysteine => cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine"}
{"X":35130,"RHEA_ID":33240,"DIRECTION":"LR","MASTER_ID":33239,"ecocyc":"RXN-14249","metacyc":"RXN-14249","compounds":"L-threonine + NAD(+) => aminoacetone + CO2 + NADH"}
{"X":35131,"RHEA_ID":33241,"compounds":"aminoacetone + CO2 + NADH => L-threonine + NAD(+)"}
{"X":35132,"RHEA_ID":43197,"DIRECTION":"LR","MASTER_ID":43196,"metacyc":"RXN-12479","compounds":"adenosine(4) in tRNA(His) + S-adenosyl-L-methionine => 2'-O-methyladenosine(4) in tRNA(His) + H(+) + S-adenosyl-L-homocysteine"}
{"X":35133,"RHEA_ID":43198,"compounds":"2'-O-methyladenosine(4) in tRNA(His) + H(+) + S-adenosyl-L-homocysteine => adenosine(4) in tRNA(His) + S-adenosyl-L-methionine"}
{"X":35134,"RHEA_ID":33244,"compounds":"L-tetrahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-7-(methylsulfanyl)heptanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":35135,"RHEA_ID":33245,"compounds":"(E)-7-(methylsulfanyl)heptanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-tetrahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}
{"X":35136,"RHEA_ID":43201,"DIRECTION":"LR","MASTER_ID":43200,"metacyc":"RXN-12463","compounds":"cytidine(1920) in 23S rRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(1920) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":35137,"RHEA_ID":33247,"compounds":"O2 + putrescine = 1-pyrroline + H2O2 + NH4(+)"}
{"X":35138,"RHEA_ID":33248,"compounds":"O2 + putrescine => 1-pyrroline + H2O2 + NH4(+)"}
{"X":35139,"RHEA_ID":33249,"compounds":"1-pyrroline + H2O2 + NH4(+) => O2 + putrescine"}
{"X":35140,"RHEA_ID":43205,"DIRECTION":"LR","MASTER_ID":43204,"metacyc":"RXN-12462","compounds":"cytidine(1409) in 16S rRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(1409) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":35141,"RHEA_ID":43206,"compounds":"2'-O-methylcytidine(1409) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1409) in 16S rRNA + S-adenosyl-L-methionine"}
{"X":35142,"RHEA_ID":33252,"DIRECTION":"LR","MASTER_ID":33251,"metacyc":"RXN-1803","compounds":"2 sucrose => 6-kestotriose + beta-D-glucose"}
{"X":35143,"RHEA_ID":33253,"compounds":"6-kestotriose + beta-D-glucose => 2 sucrose"}
{"X":35144,"RHEA_ID":43209,"DIRECTION":"LR","MASTER_ID":43208,"metacyc":"RXN-12461","compounds":"carboxymethyluridine(34) in tRNA + S-adenosyl-L-methionine => 5-(2-methoxy-2-oxoethyl)uridine(34) in tRNA + S-adenosyl-L-homocysteine"}
{"X":35145,"RHEA_ID":33255,"DIRECTION":"UN","MASTER_ID":33255,"ec":"2.1.1.163","compounds":"2-demethylmenaquinol-7 + S-adenosyl-L-methionine = H(+) + menaquinol-7 + S-adenosyl-L-homocysteine"}
{"X":35146,"RHEA_ID":33256,"DIRECTION":"LR","MASTER_ID":33255,"metacyc":"RXN-9191","compounds":"2-demethylmenaquinol-7 + S-adenosyl-L-methionine => H(+) + menaquinol-7 + S-adenosyl-L-homocysteine"}
{"X":35147,"RHEA_ID":33257,"compounds":"H(+) + menaquinol-7 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-7 + S-adenosyl-L-methionine"}
{"X":35148,"RHEA_ID":43213,"DIRECTION":"LR","MASTER_ID":43212,"metacyc":"RXN-12464","compounds":"adenosine(1067) in 23S rRNA + S-adenosyl-L-methionine => 2'-O-methyladenosine(1067) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":35149,"RHEA_ID":43214,"compounds":"2'-O-methyladenosine(1067) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => adenosine(1067) in 23S rRNA + S-adenosyl-L-methionine"}
{"X":35150,"RHEA_ID":33260,"compounds":"4-aminoimidazole + H(+) + 2 H2O => N-formimidoylglycine + NH4(+)"}
{"X":35151,"RHEA_ID":33261,"compounds":"N-formimidoylglycine + NH4(+) => 4-aminoimidazole + H(+) + 2 H2O"}
{"X":35152,"RHEA_ID":43217,"compounds":"(24S)-hydroxycholesterol + 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine => (24S)-24-hydroxycholesterol ester + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":35153,"RHEA_ID":43218,"compounds":"(24S)-24-hydroxycholesterol ester + 1-hexadecanoyl-sn-glycero-3-phosphocholine => (24S)-hydroxycholesterol + 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine"}
{"X":35154,"RHEA_ID":33264,"DIRECTION":"LR","MASTER_ID":33263,"metacyc":"RXN-4602","compounds":"L-phenylalanine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-phenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":35155,"RHEA_ID":33265,"compounds":"(E)-phenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-phenylalanine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}
{"X":35156,"RHEA_ID":53213,"compounds":"17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase] => 17beta,18-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":35157,"RHEA_ID":33267,"compounds":"(S)-2,3,4,5-tetrahydrodipicolinate + 2 H2O + meso-2,6-diaminoheptanedioate + NADP(+) = 2 (S)-2-amino-6-oxoheptanedioate + NADPH + NH4(+)"}
{"X":35158,"RHEA_ID":33268,"compounds":"(S)-2,3,4,5-tetrahydrodipicolinate + 2 H2O + meso-2,6-diaminoheptanedioate + NADP(+) => 2 (S)-2-amino-6-oxoheptanedioate + NADPH + NH4(+)"}
{"X":35159,"RHEA_ID":33269,"compounds":"2 (S)-2-amino-6-oxoheptanedioate + NADPH + NH4(+) => (S)-2,3,4,5-tetrahydrodipicolinate + 2 H2O + meso-2,6-diaminoheptanedioate + NADP(+)"}
{"X":35160,"RHEA_ID":43225,"compounds":"(24S)-hydroxycholesterol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => (24S)-hydroxycholesterol 3-linoleoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":35161,"RHEA_ID":33271,"compounds":"a triacyl-sn-glycerol + H2O = a 1,2-diacyl-sn-glycerol + a fatty acid + H(+)"}
{"X":35162,"RHEA_ID":33272,"DIRECTION":"LR","MASTER_ID":33271,"metacyc":"TRIACYLGLYCEROL-LIPASE-RXN","compounds":"a triacyl-sn-glycerol + H2O => a 1,2-diacyl-sn-glycerol + a fatty acid + H(+)"}
{"X":35163,"RHEA_ID":33273,"compounds":"a 1,2-diacyl-sn-glycerol + a fatty acid + H(+) => a triacyl-sn-glycerol + H2O"}
{"X":35164,"RHEA_ID":43229,"compounds":"L-glutamine(104)-[histone H2A] + S-adenosyl-L-methionine => H(+) + N(5)-methyl-L-glutamine(104)-[histone H2A] + S-adenosyl-L-homocysteine"}
{"X":35165,"RHEA_ID":43230,"compounds":"H(+) + N(5)-methyl-L-glutamine(104)-[histone H2A] + S-adenosyl-L-homocysteine => L-glutamine(104)-[histone H2A] + S-adenosyl-L-methionine"}
{"X":35166,"RHEA_ID":33276,"compounds":"a 1,2-diacyl-sn-glycerol + H2O => a 2-acylglycerol + a fatty acid + H(+)"}
{"X":35167,"RHEA_ID":33277,"compounds":"a 2-acylglycerol + a fatty acid + H(+) => a 1,2-diacyl-sn-glycerol + H2O"}
{"X":35168,"RHEA_ID":43233,"DIRECTION":"LR","MASTER_ID":43232,"metacyc":"RXN-3944","compounds":"H2O + isatin => H(+) + isatinate"}
{"X":35169,"RHEA_ID":43234,"compounds":"H(+) + isatinate => H2O + isatin"}
{"X":35170,"RHEA_ID":33280,"DIRECTION":"LR","MASTER_ID":33279,"metacyc":"RXN-1402","compounds":"L-tryptophan + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-(indol-3-yl)acetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":35171,"RHEA_ID":33281,"compounds":"(E)-(indol-3-yl)acetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-tryptophan + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}
{"X":35172,"RHEA_ID":43237,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O => 1,2-dihexadecanoyl-sn-glycerol + phosphate"}
{"X":35173,"RHEA_ID":43238,"compounds":"1,2-dihexadecanoyl-sn-glycerol + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O"}
{"X":35174,"RHEA_ID":33284,"compounds":"2-hydroxycyclohexan-1-one + NADPH + O2 => 6-oxohexanoate + H2O + NADP(+)"}
{"X":35175,"RHEA_ID":33285,"compounds":"6-oxohexanoate + H2O + NADP(+) => 2-hydroxycyclohexan-1-one + NADPH + O2"}
{"X":35176,"RHEA_ID":33286,"compounds":"2-hydroxycyclohexan-1-one + NADPH + O2 <=> 6-oxohexanoate + H2O + NADP(+)"}
{"X":35177,"RHEA_ID":43242,"compounds":"1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O"}
{"X":35178,"RHEA_ID":33288,"compounds":"A + spermidine => 1-pyrroline + AH2 + propane-1,3-diamine"}
{"X":35179,"RHEA_ID":33289,"compounds":"1-pyrroline + AH2 + propane-1,3-diamine => A + spermidine"}
{"X":35180,"RHEA_ID":43245,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + phosphate"}
{"X":35181,"RHEA_ID":43246,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + phosphate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O"}
{"X":35182,"RHEA_ID":33292,"DIRECTION":"LR","MASTER_ID":33291,"metacyc":"RXNQT-4312","compounds":"L-pentahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-8-(methylsulfanyl)octanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":35183,"RHEA_ID":33293,"compounds":"(E)-8-(methylsulfanyl)octanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-pentahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}
{"X":35184,"RHEA_ID":53241,"compounds":"cholesta-5,7-dien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => cholesta-5,7-dien-3beta,25-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":35185,"RHEA_ID":33295,"DIRECTION":"UN","MASTER_ID":33295,"ec":"1.14.14.42","compounds":"L-hexahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-9-(methylsulfanyl)nonanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":35186,"RHEA_ID":33296,"DIRECTION":"LR","MASTER_ID":33295,"metacyc":"RXNQT-4313","compounds":"L-hexahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-9-(methylsulfanyl)nonanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":35187,"RHEA_ID":33297,"compounds":"(E)-9-(methylsulfanyl)nonanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-hexahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}
{"X":35188,"RHEA_ID":53245,"compounds":"cholesta-5,7-dien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => cholesta-5,7-dien-3beta,24S-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":35189,"RHEA_ID":33299,"DIRECTION":"UN","MASTER_ID":33299,"ec":"2.5.1.46","compounds":"[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine"}
{"X":35190,"RHEA_ID":33300,"DIRECTION":"LR","MASTER_ID":33299,"metacyc":"2.5.1.46-RXN","compounds":"[eIF5A protein]-L-lysine + spermidine => [eIF5A protein]-deoxyhypusine + propane-1,3-diamine"}
{"X":35191,"RHEA_ID":33301,"compounds":"[eIF5A protein]-deoxyhypusine + propane-1,3-diamine => [eIF5A protein]-L-lysine + spermidine"}
{"X":35192,"RHEA_ID":43257,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate"}
{"X":35193,"RHEA_ID":43258,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O"}
{"X":35194,"RHEA_ID":33308,"DIRECTION":"LR","MASTER_ID":33307,"ecocyc":"RXN0-2522","metacyc":"RXN0-2522","compounds":"(2R)-2-O-(alpha-D-mannosyl)-glycerate(out) + N(pros)-phospho-L-histidyl-[protein] => (2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate(in) + L-histidyl-[protein]"}
{"X":35195,"RHEA_ID":33309,"compounds":"(2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate(in) + L-histidyl-[protein] => (2R)-2-O-(alpha-D-mannosyl)-glycerate(out) + N(pros)-phospho-L-histidyl-[protein]"}
{"X":35196,"RHEA_ID":43261,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate"}
{"X":35197,"RHEA_ID":43262,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O"}
{"X":35198,"RHEA_ID":33312,"compounds":"2 A + hydroxylamine + NH4(+) => 2 AH2 + H(+) + H2O + N2"}
{"X":35199,"RHEA_ID":33313,"compounds":"2 AH2 + H(+) + H2O + N2 => 2 A + hydroxylamine + NH4(+)"}
{"X":35200,"RHEA_ID":33314,"compounds":"2 A + hydroxylamine + NH4(+) <=> 2 AH2 + H(+) + H2O + N2"}
{"X":35201,"RHEA_ID":43266,"compounds":"1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + eicosanoyl-CoA"}
{"X":35202,"RHEA_ID":33316,"compounds":"a 1-acyl-sn-glycero-3-phosphate + hexadecanoyl-CoA => 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":35203,"RHEA_ID":33317,"compounds":"1-acyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA => a 1-acyl-sn-glycero-3-phosphate + hexadecanoyl-CoA"}
{"X":35204,"RHEA_ID":43269,"compounds":"ganglioside GM3 + UDP-N-acetyl-alpha-D-galactosamine => ganglioside GM2 + H(+) + UDP"}
{"X":35205,"RHEA_ID":33319,"compounds":"a 1-acyl-sn-glycero-3-phosphate + octadecanoyl-CoA = a 1-acyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":35206,"RHEA_ID":43271,"compounds":"ganglioside GM3 + UDP-N-acetyl-alpha-D-galactosamine <=> ganglioside GM2 + H(+) + UDP"}
{"X":35207,"RHEA_ID":33321,"compounds":"a 1-acyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA => a 1-acyl-sn-glycero-3-phosphate + octadecanoyl-CoA"}
{"X":35208,"RHEA_ID":43273,"compounds":"ganglioside GD3 + UDP-N-acetyl-alpha-D-galactosamine => ganglioside GD2 + H(+) + UDP"}
{"X":35209,"RHEA_ID":33323,"compounds":"a 1-acyl-sn-glycero-3-phosphate + tetradecanoyl-CoA = a 1-acyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":35210,"RHEA_ID":43275,"compounds":"ganglioside GD3 + UDP-N-acetyl-alpha-D-galactosamine <=> ganglioside GD2 + H(+) + UDP"}
{"X":35211,"RHEA_ID":33325,"compounds":"a 1-acyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA => a 1-acyl-sn-glycero-3-phosphate + tetradecanoyl-CoA"}
{"X":35212,"RHEA_ID":43277,"compounds":"ganglioside GD1a + UDP-N-acetyl-alpha-D-galactosamine => H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->3)]-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP"}
{"X":35213,"RHEA_ID":33335,"compounds":"1,2-dioctadecanoyl-sn-glycero-3-phosphate + H2O = 1,2-dioctadecanoyl-sn-glycerol + phosphate"}
{"X":35214,"RHEA_ID":43279,"compounds":"ganglioside GD1a + UDP-N-acetyl-alpha-D-galactosamine <=> H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->3)]-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP"}
{"X":35215,"RHEA_ID":33337,"compounds":"1,2-dioctadecanoyl-sn-glycerol + phosphate => 1,2-dioctadecanoyl-sn-glycero-3-phosphate + H2O"}
{"X":35216,"RHEA_ID":33338,"compounds":"1,2-dioctadecanoyl-sn-glycero-3-phosphate + H2O <=> 1,2-dioctadecanoyl-sn-glycerol + phosphate"}
{"X":35217,"RHEA_ID":33339,"compounds":"4-hydroxysphinganine + hexacosanoyl-CoA = CoA + H(+) + N-(hexacosanoyl)-(4R)-hydroxysphinganine"}
{"X":35218,"RHEA_ID":43283,"compounds":"1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O <=> 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate"}
{"X":35219,"RHEA_ID":33341,"compounds":"CoA + H(+) + N-(hexacosanoyl)-(4R)-hydroxysphinganine => 4-hydroxysphinganine + hexacosanoyl-CoA"}
{"X":35220,"RHEA_ID":43285,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate"}
{"X":35221,"RHEA_ID":33343,"compounds":"glycine + O2 = 2-iminoacetate + H2O2"}
{"X":35222,"RHEA_ID":33344,"DIRECTION":"LR","MASTER_ID":33343,"metacyc":"RXN-12614","compounds":"glycine + O2 => 2-iminoacetate + H2O2"}
{"X":35223,"RHEA_ID":33345,"compounds":"2-iminoacetate + H2O2 => glycine + O2"}
{"X":35224,"RHEA_ID":43289,"compounds":"1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + phosphate"}
{"X":35225,"RHEA_ID":33347,"compounds":"2-iminoacetate + H2O = glyoxylate + NH4(+)"}
{"X":35226,"RHEA_ID":43291,"compounds":"1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O <=> 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + phosphate"}
{"X":35227,"RHEA_ID":33349,"compounds":"glyoxylate + NH4(+) => 2-iminoacetate + H2O"}
{"X":35228,"RHEA_ID":43293,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate"}
{"X":35229,"RHEA_ID":33351,"compounds":"hexacosanoyl-CoA + sphinganine = CoA + H(+) + N-hexacosanoylsphinganine"}
{"X":35230,"RHEA_ID":43295,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate"}
{"X":35231,"RHEA_ID":33353,"compounds":"CoA + H(+) + N-hexacosanoylsphinganine => hexacosanoyl-CoA + sphinganine"}
{"X":35232,"RHEA_ID":43297,"compounds":"1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate"}
{"X":35233,"RHEA_ID":33355,"compounds":"a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA = 1-octadecanoyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + CoA"}
{"X":35234,"RHEA_ID":43299,"compounds":"1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O <=> 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate"}
{"X":35235,"RHEA_ID":33357,"compounds":"1-octadecanoyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + CoA => a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA"}
{"X":35236,"RHEA_ID":33358,"compounds":"a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA <=> 1-octadecanoyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + CoA"}
{"X":35237,"RHEA_ID":33359,"compounds":"(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":35238,"RHEA_ID":33360,"compounds":"(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine => 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":35239,"RHEA_ID":33361,"compounds":"1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine"}
{"X":35240,"RHEA_ID":43305,"compounds":"3'-phosphoadenylyl sulfate + a D-galactosylceramide => 1-(3-O-sulfo-beta-D-galactosyl)-ceramide + adenosine 3',5'-bisphosphate + H(+)"}
{"X":35241,"RHEA_ID":33363,"DIRECTION":"UN","MASTER_ID":33363,"ec":"2.7.1.197","compounds":"D-mannitol(out) + N(pros)-phospho-L-histidyl-[protein] = D-mannitol 1-phosphate(in) + L-histidyl-[protein]"}
{"X":35242,"RHEA_ID":43307,"compounds":"3'-phosphoadenylyl sulfate + a D-galactosylceramide <=> 1-(3-O-sulfo-beta-D-galactosyl)-ceramide + adenosine 3',5'-bisphosphate + H(+)"}
{"X":35243,"RHEA_ID":33365,"compounds":"D-mannitol 1-phosphate(in) + L-histidyl-[protein] => D-mannitol(out) + N(pros)-phospho-L-histidyl-[protein]"}
{"X":35244,"RHEA_ID":43309,"compounds":"1-hexadecanoyl-sn-glycerol + ATP => 1-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":35245,"RHEA_ID":33367,"DIRECTION":"UN","MASTER_ID":33367,"ec":"2.7.1.199","compounds":"D-glucose(out) + N(pros)-phospho-L-histidyl-[protein] = D-glucose 6-phosphate(in) + L-histidyl-[protein]"}
{"X":35246,"RHEA_ID":43311,"compounds":"1-hexadecanoyl-sn-glycerol + ATP <=> 1-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":35247,"RHEA_ID":33369,"compounds":"D-glucose 6-phosphate(in) + L-histidyl-[protein] => D-glucose(out) + N(pros)-phospho-L-histidyl-[protein]"}
{"X":35248,"RHEA_ID":43313,"compounds":"ATP + N-(hexanoyl)sphing-4-enine => ADP + H(+) + N-hexanoylsphing-4-enine 1-phosphate"}
{"X":35249,"RHEA_ID":43314,"compounds":"ADP + H(+) + N-hexanoylsphing-4-enine 1-phosphate => ATP + N-(hexanoyl)sphing-4-enine"}
{"X":35250,"RHEA_ID":33372,"DIRECTION":"LR","MASTER_ID":33371,"ecocyc":"TRANS-RXN-168","metacyc":"TRANS-RXN-168","compounds":"alpha,alpha-trehalose(out) + N(pros)-phospho-L-histidyl-[protein] => alpha,alpha-trehalose 6-phosphate(in) + L-histidyl-[protein]"}
{"X":35251,"RHEA_ID":33373,"compounds":"alpha,alpha-trehalose 6-phosphate(in) + L-histidyl-[protein] => alpha,alpha-trehalose(out) + N(pros)-phospho-L-histidyl-[protein]"}
{"X":35252,"RHEA_ID":43317,"compounds":"2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + ATP => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":35253,"RHEA_ID":33375,"compounds":"a 1-acylglycerone 3-phosphate + H(+) + NADPH = a 1-acyl-sn-glycero-3-phosphate + NADP(+)"}
{"X":35254,"RHEA_ID":33376,"compounds":"a 1-acylglycerone 3-phosphate + H(+) + NADPH => a 1-acyl-sn-glycero-3-phosphate + NADP(+)"}
{"X":35255,"RHEA_ID":33377,"compounds":"a 1-acyl-sn-glycero-3-phosphate + NADP(+) => a 1-acylglycerone 3-phosphate + H(+) + NADPH"}
{"X":35256,"RHEA_ID":33378,"compounds":"a 1-acylglycerone 3-phosphate + H(+) + NADPH <=> a 1-acyl-sn-glycero-3-phosphate + NADP(+)"}
{"X":35257,"RHEA_ID":43322,"compounds":"a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine => 1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + sphingomyelin"}
{"X":35258,"RHEA_ID":43323,"compounds":"1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + sphingomyelin <=> a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine"}
{"X":35259,"RHEA_ID":33381,"compounds":"(4R)-hydroxyeicosasphinganine + phosphate => 4-hydroxyeicosasphinganine 1-phosphate + H2O"}
{"X":35260,"RHEA_ID":33382,"compounds":"4-hydroxyeicosasphinganine 1-phosphate + H2O <=> (4R)-hydroxyeicosasphinganine + phosphate"}
{"X":35261,"RHEA_ID":43326,"compounds":"1,2-dihexadecanoyl-sn-glycerol + sphingomyelin => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine"}
{"X":35262,"RHEA_ID":43327,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine <=> 1,2-dihexadecanoyl-sn-glycerol + sphingomyelin"}
{"X":35263,"RHEA_ID":33385,"compounds":"(S)-malyl N-acetyl-alpha-D-glucosaminide + H(+) + UDP => (S)-malate + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":35264,"RHEA_ID":33386,"compounds":"(S)-malate + UDP-N-acetyl-alpha-D-glucosamine <=> (S)-malyl N-acetyl-alpha-D-glucosaminide + H(+) + UDP"}
{"X":35265,"RHEA_ID":33387,"compounds":"cadaverine + S-adenosyl 3-(methylsulfanyl)propylamine = aminopropylcadaverine + H(+) + S-methyl-5'-thioadenosine"}
{"X":35266,"RHEA_ID":33388,"DIRECTION":"LR","MASTER_ID":33387,"ecocyc":"RXN0-5217","metacyc":"RXN0-5217","compounds":"cadaverine + S-adenosyl 3-(methylsulfanyl)propylamine => aminopropylcadaverine + H(+) + S-methyl-5'-thioadenosine"}
{"X":35267,"RHEA_ID":33389,"compounds":"aminopropylcadaverine + H(+) + S-methyl-5'-thioadenosine => cadaverine + S-adenosyl 3-(methylsulfanyl)propylamine"}
{"X":35268,"RHEA_ID":43333,"DIRECTION":"LR","MASTER_ID":43332,"ecocyc":"RXN-11586","metacyc":"RXN-11586","compounds":"adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine => 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine"}
{"X":35269,"RHEA_ID":33391,"compounds":"C20 sphinganine 1-phosphate + H2O = C20 sphinganine + phosphate"}
{"X":35270,"RHEA_ID":43335,"compounds":"adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine <=> 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine"}
{"X":35271,"RHEA_ID":33393,"compounds":"C20 sphinganine + phosphate => C20 sphinganine 1-phosphate + H2O"}
{"X":35272,"RHEA_ID":33394,"compounds":"C20 sphinganine 1-phosphate + H2O <=> C20 sphinganine + phosphate"}
{"X":35273,"RHEA_ID":33395,"compounds":"H2O + N(epsilon)-(5'-guanylyl)-N(alpha)-acetyl-L-lysine methyl ester = GMP + N(alpha)-acetyl-L-lysine methyl ester"}
{"X":35274,"RHEA_ID":53331,"compounds":"H2O + UDP-2,3-diacyl-alpha-D-glucosamine <=> 2,3-diacyl-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP"}
{"X":35275,"RHEA_ID":33397,"compounds":"GMP + N(alpha)-acetyl-L-lysine methyl ester => H2O + N(epsilon)-(5'-guanylyl)-N(alpha)-acetyl-L-lysine methyl ester"}
{"X":35276,"RHEA_ID":33398,"compounds":"H2O + N(epsilon)-(5'-guanylyl)-N(alpha)-acetyl-L-lysine methyl ester <=> GMP + N(alpha)-acetyl-L-lysine methyl ester"}
{"X":35277,"RHEA_ID":33399,"DIRECTION":"UN","MASTER_ID":33399,"ec":"2.7.1.192","compounds":"N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-muramate(out) = L-histidyl-[protein] + N-acetyl-beta-D-muramate 6-phosphate(in)"}
{"X":35278,"RHEA_ID":53335,"compounds":"2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 <=> 2-[15(S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-glycerol"}
{"X":35279,"RHEA_ID":33401,"compounds":"L-histidyl-[protein] + N-acetyl-beta-D-muramate 6-phosphate(in) => N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-muramate(out)"}
{"X":35280,"RHEA_ID":43345,"DIRECTION":"LR","MASTER_ID":43344,"ecocyc":"RXN-9789","metacyc":"RXN-9789","compounds":"[sulfur-carrier protein ThiS]-C-terminal Gly-Gly + ATP + H(+) => [sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + diphosphate"}
{"X":35281,"RHEA_ID":33403,"compounds":"ATP + L-threonine = diphosphate + L-threonyl-5'-AMP"}
{"X":35282,"RHEA_ID":33405,"compounds":"diphosphate + L-threonyl-5'-AMP => ATP + L-threonine"}
{"X":35283,"RHEA_ID":33406,"compounds":"ATP + L-threonine <=> diphosphate + L-threonyl-5'-AMP"}
{"X":35284,"RHEA_ID":33407,"compounds":"ATP + glycine + H(+) = diphosphate + glycyl-5'-AMP"}
{"X":35285,"RHEA_ID":43351,"compounds":"cholesteryl (9Z-octadecenoate)(in) <=> cholesteryl (9Z-octadecenoate)(out)"}
{"X":35286,"RHEA_ID":33409,"compounds":"diphosphate + glycyl-5'-AMP => ATP + glycine + H(+)"}
{"X":35287,"RHEA_ID":33410,"compounds":"ATP + glycine + H(+) <=> diphosphate + glycyl-5'-AMP"}
{"X":35288,"RHEA_ID":33411,"compounds":"(S)-malyl N-acetyl-alpha-D-glucosaminide + H2O = (S)-malyl alpha-D-glucosaminide + acetate"}
{"X":35289,"RHEA_ID":43355,"compounds":"1,2,3-tri-(9Z-octadecenoyl)-glycerol(in) <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol(out)"}
{"X":35290,"RHEA_ID":43356,"compounds":"cholesteryl (9Z,12Z)-octadecadienoate(in) = cholesteryl (9Z,12Z)-octadecadienoate(out)"}
{"X":35291,"RHEA_ID":33414,"compounds":"(S)-malyl N-acetyl-alpha-D-glucosaminide + H2O <=> (S)-malyl alpha-D-glucosaminide + acetate"}
{"X":35292,"RHEA_ID":33415,"DIRECTION":"UN","MASTER_ID":33415,"ec":"3.7.1.18","compounds":"bornane-2,6-dione + H2O = [(1S)-4-hydroxy-2,2,3-trimethylcyclopent-3-enyl]acetate + H(+)"}
{"X":35293,"RHEA_ID":43359,"compounds":"cholesteryl (9Z,12Z)-octadecadienoate(in) <=> cholesteryl (9Z,12Z)-octadecadienoate(out)"}
{"X":35294,"RHEA_ID":43360,"compounds":"an N-acylsphinganine + UDP-alpha-D-glucose = an N-acyl-beta-D-glucosyl-(1<->1')-sphinganine + H(+) + UDP"}
{"X":35295,"RHEA_ID":43361,"compounds":"an N-acylsphinganine + UDP-alpha-D-glucose => an N-acyl-beta-D-glucosyl-(1<->1')-sphinganine + H(+) + UDP"}
{"X":35296,"RHEA_ID":33419,"DIRECTION":"UN","MASTER_ID":33419,"ec":"6.2.1.38","compounds":"[(1R)-2,2,3-trimethyl-2-oxocyclopent-3-en-1-yl]acetate + ATP + CoA = [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + AMP + diphosphate"}
{"X":35297,"RHEA_ID":43363,"compounds":"an N-acylsphinganine + UDP-alpha-D-glucose <=> an N-acyl-beta-D-glucosyl-(1<->1')-sphinganine + H(+) + UDP"}
{"X":35298,"RHEA_ID":43364,"compounds":"L-erythro-N-acylsphing-4-enine + UDP-alpha-D-glucose = beta-D-glucosyl-L-erythro-N-acylsphing-4-enine + H(+) + UDP"}
{"X":35299,"RHEA_ID":43365,"compounds":"L-erythro-N-acylsphing-4-enine + UDP-alpha-D-glucose => beta-D-glucosyl-L-erythro-N-acylsphing-4-enine + H(+) + UDP"}
{"X":35300,"RHEA_ID":33423,"DIRECTION":"UN","MASTER_ID":33423,"ec":"2.7.1.196","compounds":"N(pros)-phospho-L-histidyl-[protein] + N,N'-diacetylchitobiose(out) = diacetylchitobiose-6'-phosphate(in) + L-histidyl-[protein]"}
{"X":35301,"RHEA_ID":43367,"compounds":"L-erythro-N-acylsphing-4-enine + UDP-alpha-D-glucose <=> beta-D-glucosyl-L-erythro-N-acylsphing-4-enine + H(+) + UDP"}
{"X":35302,"RHEA_ID":33425,"compounds":"diacetylchitobiose-6'-phosphate(in) + L-histidyl-[protein] => N(pros)-phospho-L-histidyl-[protein] + N,N'-diacetylchitobiose(out)"}
{"X":35303,"RHEA_ID":43369,"compounds":"dodecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(2-oxotridecyl)pyran-2-one + 3 CO2 + 4 CoA"}
{"X":35304,"RHEA_ID":33427,"compounds":"(S)-malyl alpha-D-glucosaminide + L-cysteine = bacillithiol + H2O"}
{"X":35305,"RHEA_ID":43371,"compounds":"dodecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(2-oxotridecyl)pyran-2-one + 3 CO2 + 4 CoA"}
{"X":35306,"RHEA_ID":33429,"compounds":"bacillithiol + H2O => (S)-malyl alpha-D-glucosaminide + L-cysteine"}
{"X":35307,"RHEA_ID":33430,"compounds":"(S)-malyl alpha-D-glucosaminide + L-cysteine <=> bacillithiol + H2O"}
{"X":35308,"RHEA_ID":33431,"DIRECTION":"UN","MASTER_ID":33431,"ec":"5.3.2.6","compounds":"(2Z,4E)-2-hydroxyhexa-2,4-dienedioate = (3E)-2-oxohex-3-enedioate"}
{"X":35309,"RHEA_ID":33432,"DIRECTION":"LR","MASTER_ID":33431,"metacyc":"RXN-13120","compounds":"(2Z,4E)-2-hydroxyhexa-2,4-dienedioate => (3E)-2-oxohex-3-enedioate"}
{"X":35310,"RHEA_ID":43376,"compounds":"5'-deoxyinosine + phosphate = 5-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine"}
{"X":35311,"RHEA_ID":33434,"DIRECTION":"BI","MASTER_ID":33431,"metacyc":"RXN-8529","compounds":"(2Z,4E)-2-hydroxyhexa-2,4-dienedioate <=> (3E)-2-oxohex-3-enedioate"}
{"X":35312,"RHEA_ID":33435,"compounds":"24-methylene-5alpha-cholest-8-en-3beta-ol = episterol"}
{"X":35313,"RHEA_ID":43379,"compounds":"5'-deoxyinosine + phosphate <=> 5-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine"}
{"X":35314,"RHEA_ID":43380,"DIRECTION":"UN","MASTER_ID":43380,"ec":"3.9.1.2","compounds":"H2O + N(omega)-phospho-L-arginyl-[protein] = L-arginyl-[protein] + phosphate"}
{"X":35315,"RHEA_ID":43381,"compounds":"H2O + N(omega)-phospho-L-arginyl-[protein] => L-arginyl-[protein] + phosphate"}
{"X":35316,"RHEA_ID":33439,"DIRECTION":"UN","MASTER_ID":33439,"ec":"1.2.3.15","compounds":"glyoxal + H2O + O2 = glyoxylate + H(+) + H2O2"}
{"X":35317,"RHEA_ID":43383,"DIRECTION":"BI","MASTER_ID":43380,"metacyc":"RXN8J2-139","compounds":"H2O + N(omega)-phospho-L-arginyl-[protein] <=> L-arginyl-[protein] + phosphate"}
{"X":35318,"RHEA_ID":43384,"DIRECTION":"UN","MASTER_ID":43384,"ec":"2.7.14.1","compounds":"ATP + L-arginyl-[protein] = ADP + H(+) + N(omega)-phospho-L-arginyl-[protein]"}
{"X":35319,"RHEA_ID":33447,"DIRECTION":"UN","MASTER_ID":33447,"ec":"1.1.1.170","compounds":"4alpha-carboxyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) = 4-methyl-5alpha-cholesta-8,24-dien-3-one + CO2 + NADPH"}
{"X":35320,"RHEA_ID":43387,"DIRECTION":"BI","MASTER_ID":43384,"metacyc":"RXN8J2-140","compounds":"ATP + L-arginyl-[protein] <=> ADP + H(+) + N(omega)-phospho-L-arginyl-[protein]"}
{"X":35321,"RHEA_ID":43388,"compounds":"1D-myo-inositol 3,4-bisphosphate + H2O = 1D-myo-inositol 3-phosphate + phosphate"}
{"X":35322,"RHEA_ID":43389,"DIRECTION":"LR","MASTER_ID":43388,"reactome":"R-HSA-1855202.2","compounds":"1D-myo-inositol 3,4-bisphosphate + H2O => 1D-myo-inositol 3-phosphate + phosphate"}
{"X":35323,"RHEA_ID":33451,"compounds":"A + H2O + N(6),N(6)-dimethyl-L-lysyl-[protein] = AH2 + formaldehyde + N(6)-methyl-L-lysyl-[protein]"}
{"X":35324,"RHEA_ID":33452,"compounds":"A + H2O + N(6),N(6)-dimethyl-L-lysyl-[protein] => AH2 + formaldehyde + N(6)-methyl-L-lysyl-[protein]"}
{"X":35325,"RHEA_ID":43392,"compounds":"1D-myo-inositol 1,3,4-trisphosphate + H2O = 1D-myo-inositol 1,3-bisphosphate + phosphate"}
{"X":35326,"RHEA_ID":33455,"compounds":"4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) = CO2 + NADPH + zymosterone"}
{"X":35327,"RHEA_ID":43395,"compounds":"1D-myo-inositol 1,3,4-trisphosphate + H2O <=> 1D-myo-inositol 1,3-bisphosphate + phosphate"}
{"X":35328,"RHEA_ID":43396,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol 3,4,5-triphosphate) + ADP + H(+)"}
{"X":35329,"RHEA_ID":33458,"compounds":"4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) <=> CO2 + NADPH + zymosterone"}
{"X":35330,"RHEA_ID":33459,"compounds":"H(+) + NADPH + zymosterone = 5alpha-cholesta-8,24-dien-3beta-ol + NADP(+)"}
{"X":35331,"RHEA_ID":43399,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ATP <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol 3,4,5-triphosphate) + ADP + H(+)"}
{"X":35332,"RHEA_ID":43400,"compounds":"N-(2-hydroxy-hexanoyl)-sphing-4-enine + UDP-alpha-D-galactose = H(+) + N-(2-hydroxy-hexanoyl)-beta-D-galactosyl-sphing-4-enine + UDP"}
{"X":35333,"RHEA_ID":33462,"compounds":"H(+) + NADPH + zymosterone <=> 5alpha-cholesta-8,24-dien-3beta-ol + NADP(+)"}
{"X":35334,"RHEA_ID":33463,"compounds":"episterol + H(+) + NADPH + O2 = ergosta-5,7,24(28)-trien-3beta-ol + 2 H2O + NADP(+)"}
{"X":35335,"RHEA_ID":33464,"DIRECTION":"LR","MASTER_ID":33463,"metacyc":"RXN3O-218","compounds":"episterol + H(+) + NADPH + O2 => ergosta-5,7,24(28)-trien-3beta-ol + 2 H2O + NADP(+)"}
{"X":35336,"RHEA_ID":43404,"compounds":"N-(2-hydroxy-hexanoyl)-sphinganine + UDP-alpha-D-galactose = H(+) + N-(2-hydroxyhexanoyl)-beta-D-galactosylsphinganine + UDP"}
{"X":35337,"RHEA_ID":43405,"compounds":"N-(2-hydroxy-hexanoyl)-sphinganine + UDP-alpha-D-galactose => H(+) + N-(2-hydroxyhexanoyl)-beta-D-galactosylsphinganine + UDP"}
{"X":35338,"RHEA_ID":33467,"DIRECTION":"UN","MASTER_ID":33467,"ec":"1.14.19.41","compounds":"ergosta-5,7,24(28)-trien-3beta-ol + H(+) + NADPH + O2 = ergosta-5,7,22,24(28)-tetraen-3beta-ol + 2 H2O + NADP(+)"}
{"X":35339,"RHEA_ID":43407,"compounds":"N-(2-hydroxy-hexanoyl)-sphinganine + UDP-alpha-D-galactose <=> H(+) + N-(2-hydroxyhexanoyl)-beta-D-galactosylsphinganine + UDP"}
{"X":35340,"RHEA_ID":33469,"compounds":"ergosta-5,7,22,24(28)-tetraen-3beta-ol + 2 H2O + NADP(+) => ergosta-5,7,24(28)-trien-3beta-ol + H(+) + NADPH + O2"}
{"X":35341,"RHEA_ID":43409,"compounds":"sphinganine + UDP-alpha-D-galactose => beta-D-galactosyl-(1<->1')-sphinganine + H(+) + UDP"}
{"X":35342,"RHEA_ID":33471,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-(4R)-4-hydroxysphinganine = a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol"}
{"X":35343,"RHEA_ID":43411,"compounds":"sphinganine + UDP-alpha-D-galactose <=> beta-D-galactosyl-(1<->1')-sphinganine + H(+) + UDP"}
{"X":35344,"RHEA_ID":43412,"compounds":"a D-galactosylceramide + H2O = D-galactose + N-acyl-sphingoid base"}
{"X":35345,"RHEA_ID":33474,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-(4R)-4-hydroxysphinganine <=> a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol"}
{"X":35346,"RHEA_ID":33475,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acylsphinganine = a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-(1D-myo-inositol)"}
{"X":35347,"RHEA_ID":33476,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acylsphinganine => a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-(1D-myo-inositol)"}
{"X":35348,"RHEA_ID":43416,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":35349,"RHEA_ID":43417,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":35350,"RHEA_ID":33479,"compounds":"an acyl-CoA + lanosterol = CoA + lanosteryl ester"}
{"X":35351,"RHEA_ID":33480,"compounds":"an acyl-CoA + lanosterol => CoA + lanosteryl ester"}
{"X":35352,"RHEA_ID":33481,"compounds":"CoA + lanosteryl ester => an acyl-CoA + lanosterol"}
{"X":35353,"RHEA_ID":53413,"DIRECTION":"LR","MASTER_ID":53412,"metacyc":"RXN-9415","compounds":"(1R,4S)-1-hydroxylimonen-2-one + H(+) + NADPH + O2 => (4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)"}
{"X":35354,"RHEA_ID":33483,"compounds":"an acyl-CoA + ergosterol = CoA + ergosteryl ester"}
{"X":35355,"RHEA_ID":33484,"compounds":"an acyl-CoA + ergosterol => CoA + ergosteryl ester"}
{"X":35356,"RHEA_ID":33485,"compounds":"CoA + ergosteryl ester => an acyl-CoA + ergosterol"}
{"X":35357,"RHEA_ID":53417,"DIRECTION":"LR","MASTER_ID":53416,"metacyc":"RXN-18505","compounds":"8-amino-8-demethylriboflavin + S-adenosyl-L-methionine => 8-demethyl-8-(methylamino)riboflavin + H(+) + S-adenosyl-L-homocysteine"}
{"X":35358,"RHEA_ID":33487,"compounds":"2-hydroxyhexacosanoyl-CoA + 4-hydroxysphinganine = CoA + H(+) + N-(2-hydroxyhexacosanoyl)phytosphingosine"}
{"X":35359,"RHEA_ID":33488,"compounds":"2-hydroxyhexacosanoyl-CoA + 4-hydroxysphinganine => CoA + H(+) + N-(2-hydroxyhexacosanoyl)phytosphingosine"}
{"X":35360,"RHEA_ID":33489,"compounds":"CoA + H(+) + N-(2-hydroxyhexacosanoyl)phytosphingosine => 2-hydroxyhexacosanoyl-CoA + 4-hydroxysphinganine"}
{"X":35361,"RHEA_ID":53421,"DIRECTION":"LR","MASTER_ID":53420,"metacyc":"RXN-18504","compounds":"8-demethyl-8-(methylamino)riboflavin + S-adenosyl-L-methionine => H(+) + roseoflavin + S-adenosyl-L-homocysteine"}
{"X":35362,"RHEA_ID":33491,"compounds":"2-hydroxyhexacosanoyl-CoA + sphinganine = CoA + H(+) + N-(2-hydroxyhexacosanoyl)sphinganine"}
{"X":35363,"RHEA_ID":33492,"compounds":"2-hydroxyhexacosanoyl-CoA + sphinganine => CoA + H(+) + N-(2-hydroxyhexacosanoyl)sphinganine"}
{"X":35364,"RHEA_ID":33493,"compounds":"CoA + H(+) + N-(2-hydroxyhexacosanoyl)sphinganine => 2-hydroxyhexacosanoyl-CoA + sphinganine"}
{"X":35365,"RHEA_ID":53425,"DIRECTION":"LR","MASTER_ID":53424,"metacyc":"SPHINGOSINE-N-ACYLTRANSFERASE-RXN","compounds":"a sphingoid base + an acyl-CoA => CoA + H(+) + N-acyl-sphingoid base"}
{"X":35366,"RHEA_ID":33495,"DIRECTION":"UN","MASTER_ID":33495,"ec":"2.5.1.n9","compounds":"all-trans-heptaprenyl diphosphate + sn-glycerol 1-phosphate = 3-heptaprenyl-sn-glycero-1-phosphate + diphosphate"}
{"X":35367,"RHEA_ID":33496,"compounds":"all-trans-heptaprenyl diphosphate + sn-glycerol 1-phosphate => 3-heptaprenyl-sn-glycero-1-phosphate + diphosphate"}
{"X":35368,"RHEA_ID":33497,"compounds":"3-heptaprenyl-sn-glycero-1-phosphate + diphosphate => all-trans-heptaprenyl diphosphate + sn-glycerol 1-phosphate"}
{"X":35369,"RHEA_ID":53429,"DIRECTION":"LR","MASTER_ID":53428,"ecocyc":"RXN-17824","metacyc":"RXN-17824","compounds":"a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] => a thymidine in DNA + S-methyl-L-cysteinyl-[protein]"}
{"X":35370,"RHEA_ID":33499,"DIRECTION":"UN","MASTER_ID":33499,"ec":"4.1.1.100","compounds":"H(+) + prephenate = 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate + CO2"}
{"X":35371,"RHEA_ID":33500,"DIRECTION":"LR","MASTER_ID":33499,"metacyc":"RXN-16263","compounds":"H(+) + prephenate => 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate + CO2"}
{"X":35372,"RHEA_ID":33501,"compounds":"3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate + CO2 => H(+) + prephenate"}
{"X":35373,"RHEA_ID":53433,"DIRECTION":"LR","MASTER_ID":53432,"metacyc":"RXN-18259","compounds":"an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose => a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP"}
{"X":35374,"RHEA_ID":33503,"compounds":"ATP + H2O + itraconazole(in) = ADP + H(+) + itraconazole(out) + phosphate"}
{"X":35375,"RHEA_ID":33504,"compounds":"ATP + H2O + itraconazole(in) => ADP + H(+) + itraconazole(out) + phosphate"}
{"X":35376,"RHEA_ID":33505,"compounds":"ADP + H(+) + itraconazole(out) + phosphate => ATP + H2O + itraconazole(in)"}
{"X":35377,"RHEA_ID":53437,"compounds":"leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":35378,"RHEA_ID":33507,"DIRECTION":"UN","MASTER_ID":33507,"ec":"4.1.2.27","compounds":"sphing-4-enine 1-phosphate = (2E)-hexadecenal + phosphoethanolamine"}
{"X":35379,"RHEA_ID":33508,"DIRECTION":"LR","MASTER_ID":33507,"reactome":"R-HSA-428676.1","compounds":"sphing-4-enine 1-phosphate => (2E)-hexadecenal + phosphoethanolamine"}
{"X":35380,"RHEA_ID":33509,"compounds":"(2E)-hexadecenal + phosphoethanolamine => sphing-4-enine 1-phosphate"}
{"X":35381,"RHEA_ID":43449,"compounds":"H(+) + hexadecanoyl-CoA + oxidized [electron-transfer flavoprotein] => (2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":35382,"RHEA_ID":33511,"compounds":"4-hydroxysphinganine 1-phosphate = 2-hydroxyhexadecanal + phosphoethanolamine"}
{"X":35383,"RHEA_ID":33512,"compounds":"4-hydroxysphinganine 1-phosphate => 2-hydroxyhexadecanal + phosphoethanolamine"}
{"X":35384,"RHEA_ID":33513,"compounds":"2-hydroxyhexadecanal + phosphoethanolamine => 4-hydroxysphinganine 1-phosphate"}
{"X":35385,"RHEA_ID":43453,"compounds":"2 H(+) + hexanoyl-CoA + 2 malonyl-CoA => 4-hydroxy-6-pentylpyran-2-one + 2 CO2 + 3 CoA"}
{"X":35386,"RHEA_ID":33515,"compounds":"2 5,6-dihydroxyindole + O2 = 2 H2O + 2 indole-5,6-quinone"}
{"X":35387,"RHEA_ID":43455,"compounds":"2 H(+) + hexanoyl-CoA + 2 malonyl-CoA <=> 4-hydroxy-6-pentylpyran-2-one + 2 CO2 + 3 CoA"}
{"X":35388,"RHEA_ID":33517,"compounds":"2 H2O + 2 indole-5,6-quinone => 2 5,6-dihydroxyindole + O2"}
{"X":35389,"RHEA_ID":43457,"compounds":"H(+) + oxidized [electron-transfer flavoprotein] + pentanoyl-CoA => (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":35390,"RHEA_ID":33519,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + sphinganine = 4-hydroxysphinganine + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":35391,"RHEA_ID":43459,"compounds":"H(+) + oxidized [electron-transfer flavoprotein] + pentanoyl-CoA <=> (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":35392,"RHEA_ID":33521,"compounds":"4-hydroxysphinganine + 2 [Fe(III)-cytochrome b5] + H2O => 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + sphinganine"}
{"X":35393,"RHEA_ID":43461,"compounds":"dodecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-undecylpyran-2-one + 2 CO2 + 3 CoA"}
{"X":35394,"RHEA_ID":33523,"compounds":"ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate + H2O = acetate + ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+)"}
{"X":35395,"RHEA_ID":43463,"compounds":"dodecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-undecylpyran-2-one + 2 CO2 + 3 CoA"}
{"X":35396,"RHEA_ID":33525,"compounds":"acetate + ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+) => ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate + H2O"}
{"X":35397,"RHEA_ID":43465,"DIRECTION":"LR","MASTER_ID":43464,"metacyc":"RXN-14278","compounds":"H(+) + hexanoyl-CoA + oxidized [electron-transfer flavoprotein] => (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":35398,"RHEA_ID":33527,"compounds":"acetyl-CoA + ergosta-5,7,22,24(28)-tetraen-3beta-ol = CoA + ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate"}
{"X":35399,"RHEA_ID":33528,"compounds":"acetyl-CoA + ergosta-5,7,22,24(28)-tetraen-3beta-ol => CoA + ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate"}
{"X":35400,"RHEA_ID":33529,"compounds":"CoA + ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate => acetyl-CoA + ergosta-5,7,22,24(28)-tetraen-3beta-ol"}
{"X":35401,"RHEA_ID":43469,"compounds":"(8Z,11Z,14Z)-eicosatrienoate + O2 => (8Z,10E,14Z)-12-hydroperoxyeicosatrienoate"}
{"X":35402,"RHEA_ID":33535,"compounds":"H2O + lanosteryl ester = a carboxylate + H(+) + lanosterol"}
{"X":35403,"RHEA_ID":43471,"compounds":"(8Z,11Z,14Z)-eicosatrienoate + O2 <=> (8Z,10E,14Z)-12-hydroperoxyeicosatrienoate"}
{"X":35404,"RHEA_ID":33537,"compounds":"a carboxylate + H(+) + lanosterol => H2O + lanosteryl ester"}
{"X":35405,"RHEA_ID":43473,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate"}
{"X":35406,"RHEA_ID":33539,"compounds":"ergosteryl ester + H2O = a carboxylate + ergosterol + H(+)"}
{"X":35407,"RHEA_ID":43475,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate"}
{"X":35408,"RHEA_ID":33541,"compounds":"a carboxylate + ergosterol + H(+) => ergosteryl ester + H2O"}
{"X":35409,"RHEA_ID":43477,"compounds":"(6Z,9Z,12Z)-octadecatrienoate + O2 => 10-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate"}
{"X":35410,"RHEA_ID":33543,"compounds":"ergosteryl palmitate + H2O = ergosterol + H(+) + hexadecanoate"}
{"X":35411,"RHEA_ID":33544,"compounds":"ergosteryl palmitate + H2O => ergosterol + H(+) + hexadecanoate"}
{"X":35412,"RHEA_ID":33545,"compounds":"ergosterol + H(+) + hexadecanoate => ergosteryl palmitate + H2O"}
{"X":35413,"RHEA_ID":43481,"compounds":"1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl-8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate"}
{"X":35414,"RHEA_ID":33547,"compounds":"H2O + lanosteryl hexadecanoate = H(+) + hexadecanoate + lanosterol"}
{"X":35415,"RHEA_ID":43483,"compounds":"1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl-8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate"}
{"X":35416,"RHEA_ID":33549,"compounds":"H(+) + hexadecanoate + lanosterol => H2O + lanosteryl hexadecanoate"}
{"X":35417,"RHEA_ID":43485,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)"}
{"X":35418,"RHEA_ID":33551,"compounds":"an N-acylsphinganine + H2O = a fatty acid + sphinganine"}
{"X":35419,"RHEA_ID":33552,"compounds":"an N-acylsphinganine + H2O => a fatty acid + sphinganine"}
{"X":35420,"RHEA_ID":33553,"compounds":"a fatty acid + sphinganine => an N-acylsphinganine + H2O"}
{"X":35421,"RHEA_ID":43489,"compounds":"7(1)-hydroxychlorophyll a + NAD(+) => chlorophyll b + H(+) + NADH"}
{"X":35422,"RHEA_ID":33555,"compounds":"an N-acyl-(4R)-4-hydroxysphinganine + H2O = 4-hydroxysphinganine + a fatty acid"}
{"X":35423,"RHEA_ID":53483,"compounds":"3beta-hydroxy-5alpha-androstan-17-one + H(+) + NADPH <=> 5alpha-androstane-3beta,17beta-diol + NADP(+)"}
{"X":35424,"RHEA_ID":33557,"compounds":"4-hydroxysphinganine + a fatty acid => an N-acyl-(4R)-4-hydroxysphinganine + H2O"}
{"X":35425,"RHEA_ID":43493,"compounds":"7(1)-hydroxychlorophyll a + NADP(+) => chlorophyll b + H(+) + NADPH"}
{"X":35426,"RHEA_ID":33559,"DIRECTION":"UN","MASTER_ID":33559,"ec":"2.3.1.198","compounds":"an acyl-CoA + sn-glycerol 3-phosphate = a 2-acyl-sn-glycerol 3-phosphate + CoA"}
{"X":35427,"RHEA_ID":33560,"compounds":"an acyl-CoA + sn-glycerol 3-phosphate => a 2-acyl-sn-glycerol 3-phosphate + CoA"}
{"X":35428,"RHEA_ID":33561,"compounds":"a 2-acyl-sn-glycerol 3-phosphate + CoA => an acyl-CoA + sn-glycerol 3-phosphate"}
{"X":35429,"RHEA_ID":53489,"compounds":"11beta-hydroxyandrost-4-ene-3,17-dione + H(+) + NADPH => 11beta,17beta-dihydroxyandrost-4-ene-3-one + NADP(+)"}
{"X":35430,"RHEA_ID":33563,"DIRECTION":"UN","MASTER_ID":33563,"ec":"2.7.1.91","compounds":"4-hydroxysphinganine + ATP = 4-hydroxysphinganine 1-phosphate + ADP + H(+)"}
{"X":35431,"RHEA_ID":53491,"compounds":"11beta-hydroxyandrost-4-ene-3,17-dione + H(+) + NADPH <=> 11beta,17beta-dihydroxyandrost-4-ene-3-one + NADP(+)"}
{"X":35432,"RHEA_ID":33565,"compounds":"4-hydroxysphinganine 1-phosphate + ADP + H(+) => 4-hydroxysphinganine + ATP"}
{"X":35433,"RHEA_ID":43501,"DIRECTION":"LR","MASTER_ID":43500,"metacyc":"RXN-11407","compounds":"beta-D-glucuronate + NAD(+) => D-glucaro-1,5-lactone + H(+) + NADH"}
{"X":35434,"RHEA_ID":33567,"DIRECTION":"UN","MASTER_ID":33567,"ec":"1.1.99.36","compounds":"A + ethanol = acetaldehyde + AH2"}
{"X":35435,"RHEA_ID":53495,"DIRECTION":"BI","MASTER_ID":53492,"metacyc":"2.1.1.86-RXN","compounds":"5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(in) <=> 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na(+)(out)"}
{"X":35436,"RHEA_ID":33569,"compounds":"acetaldehyde + AH2 => A + ethanol"}
{"X":35437,"RHEA_ID":43505,"DIRECTION":"LR","MASTER_ID":43504,"metacyc":"RXN-13090","compounds":"5-hydroxymethylfurfural + O2 => 2,5-diformylfuran + H2O2"}
{"X":35438,"RHEA_ID":33571,"DIRECTION":"UN","MASTER_ID":33571,"ec":"1.1.99.37","compounds":"A + methanol = AH2 + formaldehyde"}
{"X":35439,"RHEA_ID":53499,"compounds":"1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O <=> a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexanoate"}
{"X":35440,"RHEA_ID":33573,"compounds":"AH2 + formaldehyde => A + methanol"}
{"X":35441,"RHEA_ID":33574,"compounds":"A + methanol <=> AH2 + formaldehyde"}
{"X":35442,"RHEA_ID":33575,"compounds":"beta-D-mannose + inositol phosphophytoceramide = H2O + mannosylinositol phosphophytoceramide"}
{"X":35443,"RHEA_ID":53503,"compounds":"1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexanoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)"}
{"X":35444,"RHEA_ID":33577,"compounds":"H2O + mannosylinositol phosphophytoceramide => beta-D-mannose + inositol phosphophytoceramide"}
{"X":35445,"RHEA_ID":33578,"compounds":"beta-D-mannose + inositol phosphophytoceramide <=> H2O + mannosylinositol phosphophytoceramide"}
{"X":35446,"RHEA_ID":33579,"DIRECTION":"UN","MASTER_ID":33579,"ec":"1.1.1.335","compounds":"NAD(+) + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate = H(+) + NADH + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate"}
{"X":35447,"RHEA_ID":36905,"compounds":"7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine => 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine"}
{"X":35448,"RHEA_ID":33581,"compounds":"H(+) + NADH + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate => NAD(+) + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate"}
{"X":35449,"RHEA_ID":53509,"DIRECTION":"LR","MASTER_ID":53508,"reactome":"R-HSA-9026777.1","compounds":"(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione => (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate"}
{"X":35450,"RHEA_ID":33583,"DIRECTION":"UN","MASTER_ID":33583,"ec":"2.6.1.98","compounds":"L-glutamate + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate = 2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate"}
{"X":35451,"RHEA_ID":53510,"compounds":"(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate => (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione"}
{"X":35452,"RHEA_ID":33585,"compounds":"2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate => L-glutamate + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate"}
{"X":35453,"RHEA_ID":43521,"DIRECTION":"LR","MASTER_ID":43520,"metacyc":"RXN-13092","compounds":"2-carboxy-5-(dihydroxymethyl)furan + O2 => 2,5-dicarboxyfuran + H(+) + H2O2"}
{"X":35454,"RHEA_ID":33587,"DIRECTION":"UN","MASTER_ID":33587,"ec":"2.3.1.201","compounds":"acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate = CoA + H(+) + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate"}
{"X":35455,"RHEA_ID":53514,"compounds":"(13R)-S-cysteinylglycinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + L-glutamate => (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O"}
{"X":35456,"RHEA_ID":33589,"compounds":"CoA + H(+) + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate => acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate"}
{"X":35457,"RHEA_ID":53516,"compounds":"1-hexadecanoyl-2-(11Z,14Z,17Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (11Z,14Z,17Z)-eicosatrienoate"}
{"X":35458,"RHEA_ID":33591,"compounds":"sphinganine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoylsphinganine"}
{"X":35459,"RHEA_ID":53518,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (11Z,14Z,17Z)-eicosatrienoate => 1-hexadecanoyl-2-(11Z,14Z,17Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol"}
{"X":35460,"RHEA_ID":33593,"compounds":"CoA + H(+) + N-tetracosanoylsphinganine => sphinganine + tetracosanoyl-CoA"}
{"X":35461,"RHEA_ID":43529,"DIRECTION":"LR","MASTER_ID":43528,"metacyc":"RXN-16007","compounds":"L-serine + NAD(+) => 2-aminomalonate semialdehyde + H(+) + NADH"}
{"X":35462,"RHEA_ID":33595,"compounds":"4-hydroxysphinganine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoylphytosphingosine"}
{"X":35463,"RHEA_ID":53522,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z,12Z,15Z)-octadecatrienoate => 1-hexadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol"}
{"X":35464,"RHEA_ID":33597,"compounds":"CoA + H(+) + N-tetracosanoylphytosphingosine => 4-hydroxysphinganine + tetracosanoyl-CoA"}
{"X":35465,"RHEA_ID":43533,"DIRECTION":"LR","MASTER_ID":43532,"metacyc":"RXN-16009","compounds":"a ribonucleoside 3',5'-bisphosphate + H2O => a ribonucleoside 5'-phosphate + phosphate"}
{"X":35466,"RHEA_ID":33599,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + N-hexacosanoylsphinganine + O2 = 2 [Fe(III)-cytochrome b5] + H2O + N-(hexacosanoyl)-(4R)-hydroxysphinganine"}
{"X":35467,"RHEA_ID":33601,"compounds":"2 [Fe(III)-cytochrome b5] + H2O + N-(hexacosanoyl)-(4R)-hydroxysphinganine => 2 [Fe(II)-cytochrome b5] + 2 H(+) + N-hexacosanoylsphinganine + O2"}
{"X":35468,"RHEA_ID":33602,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + N-hexacosanoylsphinganine + O2 <=> 2 [Fe(III)-cytochrome b5] + H2O + N-(hexacosanoyl)-(4R)-hydroxysphinganine"}
{"X":35469,"RHEA_ID":33603,"compounds":"H(+) + N-hexacosanoylsphinganine + NADPH + O2 = H2O + N-(2-hydroxyhexacosanoyl)sphinganine + NADP(+)"}
{"X":35470,"RHEA_ID":33604,"compounds":"H(+) + N-hexacosanoylsphinganine + NADPH + O2 => H2O + N-(2-hydroxyhexacosanoyl)sphinganine + NADP(+)"}
{"X":35471,"RHEA_ID":33605,"compounds":"H2O + N-(2-hydroxyhexacosanoyl)sphinganine + NADP(+) => H(+) + N-hexacosanoylsphinganine + NADPH + O2"}
{"X":35472,"RHEA_ID":43541,"compounds":"[isocitrate dehydrogenase]-L-serine + ATP => [isocitrate dehydrogenase]-O-phospho-L-serine + ADP + H(+)"}
{"X":35473,"RHEA_ID":33607,"compounds":"(9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate"}
{"X":35474,"RHEA_ID":53534,"compounds":"(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O => (14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate"}
{"X":35475,"RHEA_ID":33609,"compounds":"(9Z)-octadecenoyl-CoA + AMP + diphosphate => (9Z)-octadecenoate + ATP + CoA"}
{"X":35476,"RHEA_ID":43545,"DIRECTION":"LR","MASTER_ID":43544,"metacyc":"RXN-15947","compounds":"ATP + L-glutamate + tyramine => ADP + gamma-L-glutamyltyramine + H(+) + phosphate"}
{"X":35477,"RHEA_ID":33615,"compounds":"ATP + CoA + octadecanoate = AMP + diphosphate + octadecanoyl-CoA"}
{"X":35478,"RHEA_ID":53538,"compounds":"(13R,14S)-dihydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate => (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O"}
{"X":35479,"RHEA_ID":33617,"compounds":"AMP + diphosphate + octadecanoyl-CoA => ATP + CoA + octadecanoate"}
{"X":35480,"RHEA_ID":33618,"compounds":"ATP + CoA + octadecanoate <=> AMP + diphosphate + octadecanoyl-CoA"}
{"X":35481,"RHEA_ID":43550,"compounds":"1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O"}
{"X":35482,"RHEA_ID":43551,"compounds":"1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate"}
{"X":35483,"RHEA_ID":33621,"compounds":"AMP + diphosphate + tetradecanoyl-CoA => ATP + CoA + tetradecanoate"}
{"X":35484,"RHEA_ID":33622,"compounds":"ATP + CoA + tetradecanoate <=> AMP + diphosphate + tetradecanoyl-CoA"}
{"X":35485,"RHEA_ID":43554,"compounds":"1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O"}
{"X":35486,"RHEA_ID":43555,"compounds":"1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate"}
{"X":35487,"RHEA_ID":33625,"compounds":"AMP + diphosphate + dodecanoyl-CoA => ATP + CoA + dodecanoate"}
{"X":35488,"RHEA_ID":33626,"compounds":"ATP + CoA + dodecanoate <=> AMP + diphosphate + dodecanoyl-CoA"}
{"X":35489,"RHEA_ID":43558,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O"}
{"X":35490,"RHEA_ID":33628,"compounds":"ATP + CoA + decanoate => AMP + decanoyl-CoA + diphosphate"}
{"X":35491,"RHEA_ID":33629,"compounds":"AMP + decanoyl-CoA + diphosphate => ATP + CoA + decanoate"}
{"X":35492,"RHEA_ID":33630,"compounds":"ATP + CoA + decanoate <=> AMP + decanoyl-CoA + diphosphate"}
{"X":35493,"RHEA_ID":43562,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O"}
{"X":35494,"RHEA_ID":43563,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate"}
{"X":35495,"RHEA_ID":33633,"compounds":"AMP + diphosphate + octanoyl-CoA => ATP + CoA + octanoate"}
{"X":35496,"RHEA_ID":33634,"compounds":"ATP + CoA + octanoate <=> AMP + diphosphate + octanoyl-CoA"}
{"X":35497,"RHEA_ID":43566,"compounds":"[5-(aminomethyl)-3-furyl]methyl phosphate + pyruvate => 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + L-alanine"}
{"X":35498,"RHEA_ID":33636,"compounds":"ATP + CoA + docosanoate => AMP + diphosphate + docosanoyl-CoA"}
{"X":35499,"RHEA_ID":33637,"compounds":"AMP + diphosphate + docosanoyl-CoA => ATP + CoA + docosanoate"}
{"X":35500,"RHEA_ID":33638,"compounds":"ATP + CoA + docosanoate <=> AMP + diphosphate + docosanoyl-CoA"}
{"X":35501,"RHEA_ID":43570,"compounds":"3,6-anhydro-L-galactonate + 2 H(+) + NADH => 3,6-anhydro-alpha-L-galactopyranose + H2O + NAD(+)"}
{"X":35502,"RHEA_ID":53562,"compounds":"18-hydroxy-9,10-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9,10-epoxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":35503,"RHEA_ID":33641,"compounds":"AMP + diphosphate + tetracosanoyl-CoA => ATP + CoA + tetracosanoate"}
{"X":35504,"RHEA_ID":33642,"compounds":"ATP + CoA + tetracosanoate <=> AMP + diphosphate + tetracosanoyl-CoA"}
{"X":35505,"RHEA_ID":43574,"compounds":"5-guanidino-2-oxopentanoate + AH2 + NH4(+) => A + D-arginine + H2O"}
{"X":35506,"RHEA_ID":33644,"compounds":"(9Z)-tetradecenoate + ATP + CoA => (9Z)-tetradecenoyl-CoA + AMP + diphosphate"}
{"X":35507,"RHEA_ID":33645,"compounds":"(9Z)-tetradecenoyl-CoA + AMP + diphosphate => (9Z)-tetradecenoate + ATP + CoA"}
{"X":35508,"RHEA_ID":33646,"compounds":"(9Z)-tetradecenoate + ATP + CoA <=> (9Z)-tetradecenoyl-CoA + AMP + diphosphate"}
{"X":35509,"RHEA_ID":33647,"compounds":"(9Z)-hexadecenoate + ATP + CoA = (9Z)-hexadecenoyl-CoA + AMP + diphosphate"}
{"X":35510,"RHEA_ID":43579,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + phosphate"}
{"X":35511,"RHEA_ID":33649,"compounds":"(9Z)-hexadecenoyl-CoA + AMP + diphosphate => (9Z)-hexadecenoate + ATP + CoA"}
{"X":35512,"RHEA_ID":33650,"compounds":"(9Z)-hexadecenoate + ATP + CoA <=> (9Z)-hexadecenoyl-CoA + AMP + diphosphate"}
{"X":35513,"RHEA_ID":33651,"compounds":"(9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate"}
{"X":35514,"RHEA_ID":53574,"compounds":"20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":35515,"RHEA_ID":33653,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate => (9Z,12Z)-octadecadienoate + ATP + CoA"}
{"X":35516,"RHEA_ID":33654,"compounds":"(9Z,12Z)-octadecadienoate + ATP + CoA <=> (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate"}
{"X":35517,"RHEA_ID":43586,"compounds":"5-guanidino-2-oxopentanoate + NH4(+) => H2O + iminoarginine"}
{"X":35518,"RHEA_ID":53578,"compounds":"20-hydroxy-11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":35519,"RHEA_ID":33657,"DIRECTION":"RL","MASTER_ID":33655,"reactome":"R-HSA-879585.1","compounds":"(9Z)-octadecenoate(in) => (9Z)-octadecenoate(out)"}
{"X":35520,"RHEA_ID":33658,"compounds":"(9Z)-octadecenoate(out) <=> (9Z)-octadecenoate(in)"}
{"X":35521,"RHEA_ID":43590,"compounds":"globoside NOR2 + H(+) + UDP => globoside NORint + UDP-alpha-D-galactose"}
{"X":35522,"RHEA_ID":33660,"compounds":"H(+) + N-tetracosanoylsphinganine + NADPH + O2 => H2O + N-(2-hydroxytetracosanoyl)sphinganine + NADP(+)"}
{"X":35523,"RHEA_ID":33661,"compounds":"H2O + N-(2-hydroxytetracosanoyl)sphinganine + NADP(+) => H(+) + N-tetracosanoylsphinganine + NADPH + O2"}
{"X":35524,"RHEA_ID":33662,"compounds":"H(+) + N-tetracosanoylsphinganine + NADPH + O2 <=> H2O + N-(2-hydroxytetracosanoyl)sphinganine + NADP(+)"}
{"X":35525,"RHEA_ID":43594,"compounds":"(3R)-3-hydroxy-8'-apo-beta-carotenal + 3beta-hydroxy-beta-cyclocitral => all-trans-zeaxanthin + O2"}
{"X":35526,"RHEA_ID":33664,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + N-(hexacosanoyl)-(4R)-hydroxysphinganine + O2 => 2 [Fe(III)-cytochrome b5] + H2O + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine"}
{"X":35527,"RHEA_ID":33665,"compounds":"2 [Fe(III)-cytochrome b5] + H2O + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine => 2 [Fe(II)-cytochrome b5] + 2 H(+) + N-(hexacosanoyl)-(4R)-hydroxysphinganine + O2"}
{"X":35528,"RHEA_ID":33666,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + N-(hexacosanoyl)-(4R)-hydroxysphinganine + O2 <=> 2 [Fe(III)-cytochrome b5] + H2O + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine"}
{"X":35529,"RHEA_ID":43598,"compounds":"3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde => (3R)-3-hydroxy-8'-apo-beta-carotenal + O2"}
{"X":35530,"RHEA_ID":33668,"compounds":"H(+) + N-tetracosanoylphytosphingosine + NADPH + O2 => H2O + N-(2-hydroxytetracosanoyl)phytosphingosine + NADP(+)"}
{"X":35531,"RHEA_ID":33669,"compounds":"H2O + N-(2-hydroxytetracosanoyl)phytosphingosine + NADP(+) => H(+) + N-tetracosanoylphytosphingosine + NADPH + O2"}
{"X":35532,"RHEA_ID":43601,"compounds":"3-oxoeicosanoyl-[ACP] + H(+) + NADPH => 3R-hydroxyeicosanoyl-[ACP] + NADP(+)"}
{"X":35533,"RHEA_ID":43602,"compounds":"3R-hydroxyeicosanoyl-[ACP] + NADP(+) => 3-oxoeicosanoyl-[ACP] + H(+) + NADPH"}
{"X":35534,"RHEA_ID":33672,"compounds":"2 [Fe(III)-cytochrome b5] + H2O + N-(2,3-dihydroxyhexacosanoyl)-(4S)-hydroxysphinganine => 2 [Fe(II)-cytochrome b5] + 2 H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine + O2"}
{"X":35535,"RHEA_ID":33673,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine + O2 => 2 [Fe(III)-cytochrome b5] + H2O + N-(2,3-dihydroxyhexacosanoyl)-(4S)-hydroxysphinganine"}
{"X":35536,"RHEA_ID":33674,"compounds":"2 [Fe(III)-cytochrome b5] + H2O + N-(2,3-dihydroxyhexacosanoyl)-(4S)-hydroxysphinganine <=> 2 [Fe(II)-cytochrome b5] + 2 H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine + O2"}
{"X":35537,"RHEA_ID":43606,"DIRECTION":"RL","MASTER_ID":43604,"ecocyc":"RXN-15878","metacyc":"RXN-15878","compounds":"2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin] => (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin]"}
{"X":35538,"RHEA_ID":53598,"compounds":"1-octadecanoyl-sn-glycerol + phosphate => 1-octadecanoyl-sn-glycero-3-phosphate + H2O"}
{"X":35539,"RHEA_ID":33677,"compounds":"H(+) + N-(2-hydroxytetracosanoyl)phytosphingosine + NADPH + O2 => (4S)-N-(2,3-dihydroxytetracosanoyl)-4-hydroxysphinganine + H2O + NADP(+)"}
{"X":35540,"RHEA_ID":33678,"compounds":"(4S)-N-(2,3-dihydroxytetracosanoyl)-4-hydroxysphinganine + H2O + NADP(+) <=> H(+) + N-(2-hydroxytetracosanoyl)phytosphingosine + NADPH + O2"}
{"X":35541,"RHEA_ID":33679,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + N-tetracosanoylsphinganine + O2 = 2 [Fe(III)-cytochrome b5] + H2O + N-tetracosanoylphytosphingosine"}
{"X":35542,"RHEA_ID":53602,"compounds":"1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O"}
{"X":35543,"RHEA_ID":33681,"compounds":"2 [Fe(III)-cytochrome b5] + H2O + N-tetracosanoylphytosphingosine => 2 [Fe(II)-cytochrome b5] + 2 H(+) + N-tetracosanoylsphinganine + O2"}
{"X":35544,"RHEA_ID":33682,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + N-tetracosanoylsphinganine + O2 <=> 2 [Fe(III)-cytochrome b5] + H2O + N-tetracosanoylphytosphingosine"}
{"X":35545,"RHEA_ID":43614,"compounds":"5-methyluridine(341) in tmRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(341) in tmRNA"}
{"X":35546,"RHEA_ID":33684,"compounds":"H(+) + L-serine + octadecanoyl-CoA => 3-oxoeicosasphinganine + CO2 + CoA"}
{"X":35547,"RHEA_ID":43616,"DIRECTION":"UN","MASTER_ID":43616,"ec":"2.7.7.80","compounds":"[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) = [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate"}
{"X":35548,"RHEA_ID":33686,"compounds":"H(+) + L-serine + octadecanoyl-CoA <=> 3-oxoeicosasphinganine + CO2 + CoA"}
{"X":35549,"RHEA_ID":43618,"compounds":"[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate => [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+)"}
{"X":35550,"RHEA_ID":33688,"DIRECTION":"LR","MASTER_ID":33687,"metacyc":"RXN-8859","compounds":"3'-N-debenzoyltaxol + benzoyl-CoA => CoA + H(+) + taxol"}
{"X":35551,"RHEA_ID":43620,"DIRECTION":"UN","MASTER_ID":43620,"ec":"1.1.1.276","compounds":"L-serine + NADP(+) = aminoacetaldehyde + CO2 + NADPH"}
{"X":35552,"RHEA_ID":43621,"DIRECTION":"LR","MASTER_ID":43620,"ecocyc":"RXN-16003","metacyc":"RXN-16003","compounds":"L-serine + NADP(+) => aminoacetaldehyde + CO2 + NADPH"}
{"X":35553,"RHEA_ID":43622,"compounds":"aminoacetaldehyde + CO2 + NADPH => L-serine + NADP(+)"}
{"X":35554,"RHEA_ID":33692,"compounds":"2-(1-hydroxyethyl)thiamine diphosphate + 2-oxobutanoate => (S)-2-ethyl-2-hydroxy-3-oxobutanoate + thiamine diphosphate"}
{"X":35555,"RHEA_ID":43624,"compounds":"2-aminomalonate semialdehyde + H(+) = aminoacetaldehyde + CO2"}
{"X":35556,"RHEA_ID":43625,"DIRECTION":"LR","MASTER_ID":43624,"ecocyc":"RXN-16002","metacyc":"RXN-16002","compounds":"2-aminomalonate semialdehyde + H(+) => aminoacetaldehyde + CO2"}
{"X":35557,"RHEA_ID":43626,"compounds":"aminoacetaldehyde + CO2 => 2-aminomalonate semialdehyde + H(+)"}
{"X":35558,"RHEA_ID":33696,"compounds":"C20 sphinganine + NADP(+) => 3-oxoeicosasphinganine + H(+) + NADPH"}
{"X":35559,"RHEA_ID":43628,"DIRECTION":"UN","MASTER_ID":43628,"ec":"1.1.1.387","compounds":"L-serine + NAD(+) = aminoacetaldehyde + CO2 + NADH"}
{"X":35560,"RHEA_ID":33698,"compounds":"C20 sphinganine + NADP(+) <=> 3-oxoeicosasphinganine + H(+) + NADPH"}
{"X":35561,"RHEA_ID":43630,"compounds":"aminoacetaldehyde + CO2 + NADH => L-serine + NAD(+)"}
{"X":35562,"RHEA_ID":33700,"compounds":"2 [Fe(II)-cytochrome b5] + C20 sphinganine + 2 H(+) + O2 => (4R)-hydroxyeicosasphinganine + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":35563,"RHEA_ID":43632,"DIRECTION":"UN","MASTER_ID":43632,"ec":"2.3.2.6","compounds":"an N-terminal L-alpha-aminoacyl-[protein] + L-phenylalanyl-tRNA(Phe) = an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein] + tRNA(Phe)"}
{"X":35564,"RHEA_ID":33702,"compounds":"2 [Fe(II)-cytochrome b5] + C20 sphinganine + 2 H(+) + O2 <=> (4R)-hydroxyeicosasphinganine + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":35565,"RHEA_ID":43634,"compounds":"an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein] + tRNA(Phe) => an N-terminal L-alpha-aminoacyl-[protein] + L-phenylalanyl-tRNA(Phe)"}
{"X":35566,"RHEA_ID":33704,"compounds":"(4R)-hydroxyeicosasphinganine + hexacosanoyl-CoA => CoA + H(+) + N-hexacosanoyl-C20-4-hydroxysphinganine"}
{"X":35567,"RHEA_ID":33705,"compounds":"CoA + H(+) + N-hexacosanoyl-C20-4-hydroxysphinganine => (4R)-hydroxyeicosasphinganine + hexacosanoyl-CoA"}
{"X":35568,"RHEA_ID":43637,"DIRECTION":"LR","MASTER_ID":43636,"ecocyc":"RXN0-7078","metacyc":"RXN0-7078","compounds":"H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) => 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide"}
{"X":35569,"RHEA_ID":43638,"compounds":"2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+)"}
{"X":35570,"RHEA_ID":33708,"DIRECTION":"LR","MASTER_ID":33707,"metacyc":"RXN-8626","compounds":"ATP + L-threonine => ADP + H(+) + O-phospho-L-threonine"}
{"X":35571,"RHEA_ID":33709,"compounds":"ADP + H(+) + O-phospho-L-threonine => ATP + L-threonine"}
{"X":35572,"RHEA_ID":53632,"DIRECTION":"UN","MASTER_ID":53632,"ec":"4.2.3.161","compounds":"(2E,6E)-farnesyl diphosphate = (3S)-(+)-asterisca-2(9),6-diene + diphosphate"}
{"X":35573,"RHEA_ID":43642,"compounds":"3-oxotetradecanoyl-[ACP] + CO2 + CoA => dodecanoyl-CoA + H(+) + malonyl-[ACP]"}
{"X":35574,"RHEA_ID":33712,"DIRECTION":"LR","MASTER_ID":33711,"metacyc":"RXN-9733","compounds":"4-sulfomuconolactone + H2O => 2 H(+) + maleylacetate + sulfite"}
{"X":35575,"RHEA_ID":33713,"compounds":"2 H(+) + maleylacetate + sulfite => 4-sulfomuconolactone + H2O"}
{"X":35576,"RHEA_ID":53636,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphocholine"}
{"X":35577,"RHEA_ID":43646,"compounds":"3-oxohexadecanoyl-[ACP] + CO2 + CoA => H(+) + malonyl-[ACP] + tetradecanoyl-CoA"}
{"X":35578,"RHEA_ID":33716,"compounds":"4-hydroxyeicosasphinganine 1-phosphate => 2-hydroxyoctadecanal + phosphoethanolamine"}
{"X":35579,"RHEA_ID":33717,"compounds":"2-hydroxyoctadecanal + phosphoethanolamine => 4-hydroxyeicosasphinganine 1-phosphate"}
{"X":35580,"RHEA_ID":33718,"compounds":"4-hydroxyeicosasphinganine 1-phosphate <=> 2-hydroxyoctadecanal + phosphoethanolamine"}
{"X":35581,"RHEA_ID":43650,"compounds":"3-oxooctadecanoyl-[ACP] + CO2 + CoA => H(+) + hexadecanoyl-CoA + malonyl-[ACP]"}
{"X":35582,"RHEA_ID":33720,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-hexacosanoylsphinganine => a 1,2-diacyl-sn-glycerol + N-(hexacosanoyl)-sphinganine-1-(1D-myo-inositol)"}
{"X":35583,"RHEA_ID":33721,"compounds":"a 1,2-diacyl-sn-glycerol + N-(hexacosanoyl)-sphinganine-1-(1D-myo-inositol) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-hexacosanoylsphinganine"}
{"X":35584,"RHEA_ID":43653,"compounds":"decanoyl-CoA + H(+) + malonyl-[ACP] => 3-oxododecanoyl-[ACP] + CO2 + CoA"}
{"X":35585,"RHEA_ID":43654,"compounds":"3-oxododecanoyl-[ACP] + CO2 + CoA => decanoyl-CoA + H(+) + malonyl-[ACP]"}
{"X":35586,"RHEA_ID":33724,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-tetracosanoylsphinganine => a 1,2-diacyl-sn-glycerol + N-tetracosanoylsphinganine-(1D-myo-inositol)"}
{"X":35587,"RHEA_ID":33725,"compounds":"a 1,2-diacyl-sn-glycerol + N-tetracosanoylsphinganine-(1D-myo-inositol) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-tetracosanoylsphinganine"}
{"X":35588,"RHEA_ID":43657,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + CTP => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CDP + H(+)"}
{"X":35589,"RHEA_ID":43658,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CDP + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CTP"}
{"X":35590,"RHEA_ID":33728,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-(2-hydroxyhexacosanoyl)sphinganine => a 1,2-diacyl-sn-glycerol + Ins-1-P-Cer(d18:0/2-OH-26:0)"}
{"X":35591,"RHEA_ID":33729,"compounds":"a 1,2-diacyl-sn-glycerol + Ins-1-P-Cer(d18:0/2-OH-26:0) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-(2-hydroxyhexacosanoyl)sphinganine"}
{"X":35592,"RHEA_ID":43661,"compounds":"ATP + hydrogencarbonate + propanoyl-CoA => ADP + H(+) + methylmalonyl-CoA + phosphate"}
{"X":35593,"RHEA_ID":43662,"compounds":"ADP + H(+) + methylmalonyl-CoA + phosphate => ATP + hydrogencarbonate + propanoyl-CoA"}
{"X":35594,"RHEA_ID":33732,"compounds":"1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine => a 1-acyl-sn-glycero-3-phosphocholine + a cardiolipin"}
{"X":35595,"RHEA_ID":33733,"compounds":"a 1-acyl-sn-glycero-3-phosphocholine + a cardiolipin => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine"}
{"X":35596,"RHEA_ID":43665,"compounds":"ATP + hydrogencarbonate + tetracosanoyl-CoA => 2-carboxytetracosanoyl-CoA + ADP + H(+) + phosphate"}
{"X":35597,"RHEA_ID":43666,"compounds":"2-carboxytetracosanoyl-CoA + ADP + H(+) + phosphate => ATP + hydrogencarbonate + tetracosanoyl-CoA"}
{"X":35598,"RHEA_ID":33740,"compounds":"2 H(+) + hexadecanoate + NADH => H2O + hexadecanal + NAD(+)"}
{"X":35599,"RHEA_ID":33741,"DIRECTION":"RL","MASTER_ID":33739,"reactome":"R-HSA-5696080.2","compounds":"H2O + hexadecanal + NAD(+) => 2 H(+) + hexadecanoate + NADH"}
{"X":35600,"RHEA_ID":43669,"compounds":"ATP + hexacosanoyl-CoA + hydrogencarbonate => 2-carboxyhexacosanoyl-CoA + ADP + H(+) + phosphate"}
{"X":35601,"RHEA_ID":43670,"compounds":"2-carboxyhexacosanoyl-CoA + ADP + H(+) + phosphate => ATP + hexacosanoyl-CoA + hydrogencarbonate"}
{"X":35602,"RHEA_ID":33744,"compounds":"H2O + N-acylsphing-4-enine 1-phosphate => an N-acylsphing-4-enine + phosphate"}
{"X":35603,"RHEA_ID":33745,"compounds":"an N-acylsphing-4-enine + phosphate => H2O + N-acylsphing-4-enine 1-phosphate"}
{"X":35604,"RHEA_ID":43673,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":35605,"RHEA_ID":33747,"compounds":"a 1-acyl-sn-glycerol + ATP = a 1-acyl-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":35606,"RHEA_ID":33748,"compounds":"a 1-acyl-sn-glycerol + ATP => a 1-acyl-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":35607,"RHEA_ID":33749,"compounds":"a 1-acyl-sn-glycero-3-phosphate + ADP + H(+) => a 1-acyl-sn-glycerol + ATP"}
{"X":35608,"RHEA_ID":33750,"compounds":"a 1-acyl-sn-glycerol + ATP <=> a 1-acyl-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":35609,"RHEA_ID":43678,"compounds":"1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol"}
{"X":35610,"RHEA_ID":33752,"DIRECTION":"LR","MASTER_ID":33751,"ecocyc":"PGPPHOSPHA-RXN","metacyc":"PGPPHOSPHA-RXN","compounds":"1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate"}
{"X":35611,"RHEA_ID":33753,"compounds":"1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O"}
{"X":35612,"RHEA_ID":43682,"compounds":"1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA"}
{"X":35613,"RHEA_ID":33756,"compounds":"H2O + N-hexadecanoyl-4-hydroxysphinganine => 4-hydroxysphinganine + hexadecanoate"}
{"X":35614,"RHEA_ID":33757,"compounds":"4-hydroxysphinganine + hexadecanoate => H2O + N-hexadecanoyl-4-hydroxysphinganine"}
{"X":35615,"RHEA_ID":43685,"compounds":"ATP + L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphate => AMP + diphosphate + H(+) + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]"}
{"X":35616,"RHEA_ID":33759,"compounds":"3-oxo-fatty acyl-CoA + H(+) + NADPH = a 3-hydroxyacyl-CoA + NADP(+)"}
{"X":35617,"RHEA_ID":33760,"compounds":"3-oxo-fatty acyl-CoA + H(+) + NADPH => a 3-hydroxyacyl-CoA + NADP(+)"}
{"X":35618,"RHEA_ID":33761,"compounds":"a 3-hydroxyacyl-CoA + NADP(+) => 3-oxo-fatty acyl-CoA + H(+) + NADPH"}
{"X":35619,"RHEA_ID":43689,"compounds":"N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + pyruvate => L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphoenolpyruvate"}
{"X":35620,"RHEA_ID":43690,"compounds":"L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphoenolpyruvate => N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + pyruvate"}
{"X":35621,"RHEA_ID":33764,"DIRECTION":"LR","MASTER_ID":33763,"ecocyc":"TRANSENOYLCOARED-RXN","metacyc":"TRANSENOYLCOARED-RXN","compounds":"a (2E)-enoyl-CoA + H(+) + NADPH => a 2,3-saturated acyl-CoA + NADP(+)"}
{"X":35622,"RHEA_ID":33765,"compounds":"a 2,3-saturated acyl-CoA + NADP(+) => a (2E)-enoyl-CoA + H(+) + NADPH"}
{"X":35623,"RHEA_ID":43694,"compounds":"AMP + H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase] => ADP + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]"}
{"X":35624,"RHEA_ID":33768,"compounds":"a 3-hydroxyacyl-CoA => a (2E)-enoyl-CoA + H2O"}
{"X":35625,"RHEA_ID":33769,"compounds":"a (2E)-enoyl-CoA + H2O => a 3-hydroxyacyl-CoA"}
{"X":35626,"RHEA_ID":43697,"compounds":"H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase] + phosphate => diphosphate + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]"}
{"X":35627,"RHEA_ID":43698,"compounds":"diphosphate + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] => H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase] + phosphate"}
{"X":35628,"RHEA_ID":33772,"compounds":"a 1,2-diacyl-sn-glycerol + CDP-N-methylethanolamine => 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + CMP + H(+)"}
{"X":35629,"RHEA_ID":33773,"compounds":"1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + CMP + H(+) => a 1,2-diacyl-sn-glycerol + CDP-N-methylethanolamine"}
{"X":35630,"RHEA_ID":43701,"DIRECTION":"LR","MASTER_ID":43700,"metacyc":"RXN-11587","compounds":"(2E,6E)-farnesoate + S-adenosyl-L-methionine => methyl (2E,6E)-farnesoate + S-adenosyl-L-homocysteine"}
{"X":35631,"RHEA_ID":43702,"compounds":"methyl (2E,6E)-farnesoate + S-adenosyl-L-homocysteine => (2E,6E)-farnesoate + S-adenosyl-L-methionine"}
{"X":35632,"RHEA_ID":53694,"compounds":"H(+) + prostaglandin E2 + sn-glycerol 3-phosphocholine => 2-(prostaglandin E2)-sn-glycero-3-phosphocholine + H2O"}
{"X":35633,"RHEA_ID":33777,"compounds":"1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+) => a 1,2-diacyl-sn-glycerol + CDP-N,N-dimethylethanolamine"}
{"X":35634,"RHEA_ID":43705,"compounds":"ATP + H(+) + tetradecanoate => diphosphate + tetradecanoyl-AMP"}
{"X":35635,"RHEA_ID":33779,"compounds":"6-kestotriose + sucrose = 6,6-kestotetraose + beta-D-glucose"}
{"X":35636,"RHEA_ID":33780,"compounds":"6-kestotriose + sucrose => 6,6-kestotetraose + beta-D-glucose"}
{"X":35637,"RHEA_ID":33781,"compounds":"6,6-kestotetraose + beta-D-glucose => 6-kestotriose + sucrose"}
{"X":35638,"RHEA_ID":43709,"DIRECTION":"LR","MASTER_ID":43708,"metacyc":"RXN-17320","compounds":"ATP + H(+) + hexadecanoate => diphosphate + hexadecanoyl-AMP"}
{"X":35639,"RHEA_ID":33783,"compounds":"1(F)-beta-D-fructosylsucrose + sucrose = 1,6-kestotetraose + beta-D-glucose"}
{"X":35640,"RHEA_ID":53702,"compounds":"(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine => 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O"}
{"X":35641,"RHEA_ID":33785,"compounds":"1,6-kestotetraose + beta-D-glucose => 1(F)-beta-D-fructosylsucrose + sucrose"}
{"X":35642,"RHEA_ID":43713,"compounds":"ATP + dodecanoate + H(+) => diphosphate + dodecanoyl-AMP"}
{"X":35643,"RHEA_ID":33787,"compounds":"3'-ketolactose + H2O = 3-keto-beta-D-galactose + beta-D-glucose"}
{"X":35644,"RHEA_ID":43715,"compounds":"ATP + dodecanoate + H(+) <=> diphosphate + dodecanoyl-AMP"}
{"X":35645,"RHEA_ID":33789,"compounds":"3-keto-beta-D-galactose + beta-D-glucose => 3'-ketolactose + H2O"}
{"X":35646,"RHEA_ID":43717,"DIRECTION":"LR","MASTER_ID":43716,"ecocyc":"GSDEADENYLATION-RXN","metacyc":"GSDEADENYLATION-RXN","compounds":"[glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + phosphate => [glutamine synthetase]-L-tyrosine + ADP"}
{"X":35647,"RHEA_ID":33791,"compounds":"H2O + sucrose 6(F)-phosphate = beta-D-fructose + beta-D-glucose 6-phosphate"}
{"X":35648,"RHEA_ID":33793,"compounds":"beta-D-fructose + beta-D-glucose 6-phosphate => H2O + sucrose 6(F)-phosphate"}
{"X":35649,"RHEA_ID":43721,"DIRECTION":"LR","MASTER_ID":43720,"metacyc":"RXN-11771","compounds":"juvenile hormone III carboxylate + S-adenosyl-L-methionine => juvenile hormone III + S-adenosyl-L-homocysteine"}
{"X":35650,"RHEA_ID":33795,"compounds":"H2O + sucrose = alpha-D-glucose + beta-D-fructose"}
{"X":35651,"RHEA_ID":53714,"compounds":"beta-hematin => 2 Fe(III)-heme b"}
{"X":35652,"RHEA_ID":33797,"compounds":"alpha-D-glucose + beta-D-fructose => H2O + sucrose"}
{"X":35653,"RHEA_ID":43725,"DIRECTION":"LR","MASTER_ID":43724,"metacyc":"RXN-11770","compounds":"(2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + juvenile hormone III carboxylate + oxidized [NADPH--hemoprotein reductase]"}
{"X":35654,"RHEA_ID":33799,"compounds":"L-histidinol + NAD(+) = H(+) + L-histidinal + NADH"}
{"X":35655,"RHEA_ID":53718,"compounds":"phosphate + UDP-N-acetyl-alpha-D-muramate => H(+) + N-acetyl-alpha-D-muramate 1-phosphate + UDP"}
{"X":35656,"RHEA_ID":33801,"compounds":"H(+) + L-histidinal + NADH => L-histidinol + NAD(+)"}
{"X":35657,"RHEA_ID":53720,"DIRECTION":"UN","MASTER_ID":53720,"ec":"2.7.1.221","compounds":"ATP + N-acetyl-D-muramate = ADP + H(+) + N-acetyl-alpha-D-muramate 1-phosphate"}
{"X":35658,"RHEA_ID":33803,"compounds":"H2O + L-histidinal + NAD(+) = 2 H(+) + L-histidine + NADH"}
{"X":35659,"RHEA_ID":33804,"DIRECTION":"LR","MASTER_ID":33803,"metacyc":"HISTALDEHYD-RXN","compounds":"H2O + L-histidinal + NAD(+) => 2 H(+) + L-histidine + NADH"}
{"X":35660,"RHEA_ID":33805,"compounds":"2 H(+) + L-histidine + NADH => H2O + L-histidinal + NAD(+)"}
{"X":35661,"RHEA_ID":37127,"compounds":"2-oxoglutarate + dioxidophosphate + H2O2 = CO2 + H(+) + phosphonate + succinate"}
{"X":35662,"RHEA_ID":33807,"DIRECTION":"UN","MASTER_ID":33807,"ec":"4.1.1.102","compounds":"H(+) + trans-ferulate = 2-methoxy-4-vinylphenol + CO2"}
{"X":35663,"RHEA_ID":33808,"compounds":"H(+) + trans-ferulate => 2-methoxy-4-vinylphenol + CO2"}
{"X":35664,"RHEA_ID":33809,"compounds":"2-methoxy-4-vinylphenol + CO2 => H(+) + trans-ferulate"}
{"X":35665,"RHEA_ID":43737,"DIRECTION":"LR","MASTER_ID":43736,"ecocyc":"RXN0-6998","metacyc":"RXN0-6998","compounds":"adenosine(2030) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine(2030) in 23S rRNA + S-adenosyl-L-homocysteine"}
{"X":35666,"RHEA_ID":33811,"compounds":"3 2,3-dihydroxybenzoate + 6 ATP + 3 glycine + 3 L-threonine = 6 AMP + corynebactin + 6 diphosphate + 3 H(+) + 3 H2O"}
{"X":35667,"RHEA_ID":33812,"DIRECTION":"LR","MASTER_ID":33811,"metacyc":"RXN-9374","compounds":"3 2,3-dihydroxybenzoate + 6 ATP + 3 glycine + 3 L-threonine => 6 AMP + corynebactin + 6 diphosphate + 3 H(+) + 3 H2O"}
{"X":35668,"RHEA_ID":33813,"compounds":"6 AMP + corynebactin + 6 diphosphate + 3 H(+) + 3 H2O => 3 2,3-dihydroxybenzoate + 6 ATP + 3 glycine + 3 L-threonine"}
{"X":35669,"RHEA_ID":53732,"compounds":"(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminosalicylate = 2-hydroxy-7,8-dihydropteroate + diphosphate"}
{"X":35670,"RHEA_ID":33815,"DIRECTION":"UN","MASTER_ID":33815,"ec":"2.7.8.44","compounds":"CDP-glycerol + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate = 4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)"}
{"X":35671,"RHEA_ID":33816,"DIRECTION":"LR","MASTER_ID":33815,"metacyc":"TEICHOICSYN3-RXN","compounds":"CDP-glycerol + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate => 4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)"}
{"X":35672,"RHEA_ID":33817,"compounds":"4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+) => CDP-glycerol + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate"}
{"X":35673,"RHEA_ID":33818,"compounds":"CDP-glycerol + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate <=> 4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)"}
{"X":35674,"RHEA_ID":33819,"DIRECTION":"UN","MASTER_ID":33819,"ec":"5.3.3.19","compounds":"3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate = 3-[(1E,4R)-4-hydroxycyclohex-2-en-1-ylidene]pyruvate"}
{"X":35675,"RHEA_ID":33820,"DIRECTION":"LR","MASTER_ID":33819,"metacyc":"RXN-16264","compounds":"3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate => 3-[(1E,4R)-4-hydroxycyclohex-2-en-1-ylidene]pyruvate"}
{"X":35676,"RHEA_ID":33821,"compounds":"3-[(1E,4R)-4-hydroxycyclohex-2-en-1-ylidene]pyruvate => 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate"}
{"X":35677,"RHEA_ID":47059,"compounds":"4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}
{"X":35678,"RHEA_ID":33823,"compounds":"3-(4-hydroxycyclohex-2-en-1-ylidene)pyruvate + H(+) + NADH = NAD(+) + tetrahydro-4-hydroxyphenylpyruvate"}
{"X":35679,"RHEA_ID":33824,"compounds":"3-(4-hydroxycyclohex-2-en-1-ylidene)pyruvate + H(+) + NADH => NAD(+) + tetrahydro-4-hydroxyphenylpyruvate"}
{"X":35680,"RHEA_ID":33825,"compounds":"NAD(+) + tetrahydro-4-hydroxyphenylpyruvate => 3-(4-hydroxycyclohex-2-en-1-ylidene)pyruvate + H(+) + NADH"}
{"X":35681,"RHEA_ID":53744,"DIRECTION":"UN","MASTER_ID":53744,"ec":"3.1.1.96","compounds":"glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala)"}
{"X":35682,"RHEA_ID":33827,"compounds":"ergosterol = vitamin D2"}
{"X":35683,"RHEA_ID":33828,"compounds":"ergosterol => vitamin D2"}
{"X":35684,"RHEA_ID":33829,"compounds":"vitamin D2 => ergosterol"}
{"X":35685,"RHEA_ID":53748,"compounds":"a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose = a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP"}
{"X":35686,"RHEA_ID":33835,"compounds":"H2O + N-(hexacosanoyl)-(4R)-hydroxysphinganine = 4-hydroxysphinganine + hexacosanoate"}
{"X":35687,"RHEA_ID":33836,"compounds":"H2O + N-(hexacosanoyl)-(4R)-hydroxysphinganine => 4-hydroxysphinganine + hexacosanoate"}
{"X":35688,"RHEA_ID":33837,"compounds":"4-hydroxysphinganine + hexacosanoate => H2O + N-(hexacosanoyl)-(4R)-hydroxysphinganine"}
{"X":35689,"RHEA_ID":53752,"compounds":"a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-glucose = a 1,2-diacyl-3-O-[beta-D-glucopyranosyl-(1->6)-beta-D-galactopyranosyl]-sn-glycerol + H(+) + UDP"}
{"X":35690,"RHEA_ID":33839,"DIRECTION":"UN","MASTER_ID":33839,"ec":"2.5.1.125","compounds":"(2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin + H(+) = 7-O-geranyl-2-O,3-dimethylflaviolin + diphosphate"}
{"X":35691,"RHEA_ID":33840,"compounds":"(2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin + H(+) => 7-O-geranyl-2-O,3-dimethylflaviolin + diphosphate"}
{"X":35692,"RHEA_ID":33841,"compounds":"7-O-geranyl-2-O,3-dimethylflaviolin + diphosphate => (2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin + H(+)"}
{"X":35693,"RHEA_ID":53756,"compounds":"allodeoxycholoyl-CoA + cholate = allodeoxycholate + choloyl-CoA"}
{"X":35694,"RHEA_ID":33843,"compounds":"H2O + N-tetracosanoylsphinganine = sphinganine + tetracosanoate"}
{"X":35695,"RHEA_ID":33844,"compounds":"H2O + N-tetracosanoylsphinganine => sphinganine + tetracosanoate"}
{"X":35696,"RHEA_ID":33845,"compounds":"sphinganine + tetracosanoate => H2O + N-tetracosanoylsphinganine"}
{"X":35697,"RHEA_ID":43769,"compounds":"an alkylamine + L-glutaminyl-[protein] => N(5)-alkyl-L-glutaminyl-[protein] + NH4(+)"}
{"X":35698,"RHEA_ID":33847,"compounds":"H2O + N-tetracosanoylphytosphingosine = 4-hydroxysphinganine + tetracosanoate"}
{"X":35699,"RHEA_ID":33848,"compounds":"H2O + N-tetracosanoylphytosphingosine => 4-hydroxysphinganine + tetracosanoate"}
{"X":35700,"RHEA_ID":33849,"compounds":"4-hydroxysphinganine + tetracosanoate => H2O + N-tetracosanoylphytosphingosine"}
{"X":35701,"RHEA_ID":53764,"compounds":"allocholate + lithocholoyl-CoA = allocholoyl-CoA + lithocholate"}
{"X":35702,"RHEA_ID":33851,"compounds":"GDP-alpha-D-mannose + N-tetracosanoylsphinganine-(1D-myo-inositol) = GDP + H(+) + Man-beta1-2-Ins-1-P-Cer(d18:0/24:0)"}
{"X":35703,"RHEA_ID":33852,"compounds":"GDP-alpha-D-mannose + N-tetracosanoylsphinganine-(1D-myo-inositol) => GDP + H(+) + Man-beta1-2-Ins-1-P-Cer(d18:0/24:0)"}
{"X":35704,"RHEA_ID":33853,"compounds":"GDP + H(+) + Man-beta1-2-Ins-1-P-Cer(d18:0/24:0) => GDP-alpha-D-mannose + N-tetracosanoylsphinganine-(1D-myo-inositol)"}
{"X":35705,"RHEA_ID":53768,"compounds":"allocholate + allodeoxycholoyl-CoA = allocholoyl-CoA + allodeoxycholate"}
{"X":35706,"RHEA_ID":33855,"compounds":"an inositol-1-phosphophytoceramide + GDP-alpha-D-mannose = a mannosylinositol-1-phosphophytoceramide + GDP + H(+)"}
{"X":35707,"RHEA_ID":33856,"compounds":"an inositol-1-phosphophytoceramide + GDP-alpha-D-mannose => a mannosylinositol-1-phosphophytoceramide + GDP + H(+)"}
{"X":35708,"RHEA_ID":33857,"compounds":"a mannosylinositol-1-phosphophytoceramide + GDP + H(+) => an inositol-1-phosphophytoceramide + GDP-alpha-D-mannose"}
{"X":35709,"RHEA_ID":53772,"compounds":"chenodeoxycholate + lithocholoyl-CoA = chenodeoxycholoyl-CoA + lithocholate"}
{"X":35710,"RHEA_ID":33859,"DIRECTION":"UN","MASTER_ID":33859,"ec":"4.2.1.143","compounds":"(2S-3S)-versiconal hemiacetal = H2O + versicolorin B"}
{"X":35711,"RHEA_ID":33860,"DIRECTION":"LR","MASTER_ID":33859,"metacyc":"RXN-9494","compounds":"(2S-3S)-versiconal hemiacetal => H2O + versicolorin B"}
{"X":35712,"RHEA_ID":33861,"compounds":"H2O + versicolorin B => (2S-3S)-versiconal hemiacetal"}
{"X":35713,"RHEA_ID":37179,"compounds":"(9Z)-octadecenoyl-CoA + 1-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphate = (6Z,9Z,12Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}
{"X":35714,"RHEA_ID":33863,"compounds":"menaquinone-7 + succinate = fumarate + menaquinol-7"}
{"X":35715,"RHEA_ID":33864,"compounds":"menaquinone-7 + succinate => fumarate + menaquinol-7"}
{"X":35716,"RHEA_ID":33865,"compounds":"fumarate + menaquinol-7 => menaquinone-7 + succinate"}
{"X":35717,"RHEA_ID":43789,"DIRECTION":"LR","MASTER_ID":43788,"ecocyc":"RXN0-5418","metacyc":"RXN0-5418","compounds":"acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O => ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + phosphate"}
{"X":35718,"RHEA_ID":33867,"DIRECTION":"UN","MASTER_ID":33867,"ec":"2.6.1.112","compounds":"(S)-2-ureidoglycine + glyoxylate = glycine + N-carbamoyl-2-oxoglycine"}
{"X":35719,"RHEA_ID":33868,"compounds":"(S)-2-ureidoglycine + glyoxylate => glycine + N-carbamoyl-2-oxoglycine"}
{"X":35720,"RHEA_ID":33869,"compounds":"glycine + N-carbamoyl-2-oxoglycine => (S)-2-ureidoglycine + glyoxylate"}
{"X":35721,"RHEA_ID":53784,"compounds":"beta-muricholate + deoxycholoyl-CoA = beta-muricholoyl-CoA + deoxycholate"}
{"X":35722,"RHEA_ID":33871,"compounds":"(S)-2-ureidoglycine + H2O = glyoxylate + NH4(+) + urea"}
{"X":35723,"RHEA_ID":33872,"compounds":"(S)-2-ureidoglycine + H2O => glyoxylate + NH4(+) + urea"}
{"X":35724,"RHEA_ID":33873,"compounds":"glyoxylate + NH4(+) + urea => (S)-2-ureidoglycine + H2O"}
{"X":35725,"RHEA_ID":43797,"compounds":"1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":35726,"RHEA_ID":33875,"compounds":"cholesteryl (9Z-octadecenoate) + H2O = (9Z)-octadecenoate + cholesterol + H(+)"}
{"X":35727,"RHEA_ID":33876,"compounds":"cholesteryl (9Z-octadecenoate) + H2O => (9Z)-octadecenoate + cholesterol + H(+)"}
{"X":35728,"RHEA_ID":33877,"compounds":"(9Z)-octadecenoate + cholesterol + H(+) => cholesteryl (9Z-octadecenoate) + H2O"}
{"X":35729,"RHEA_ID":53792,"compounds":"O2 + phenylmethanethiol = benzothialdehyde + H2O2"}
{"X":35730,"RHEA_ID":33879,"DIRECTION":"UN","MASTER_ID":33879,"ec":"1.1.1.329","compounds":"2-deoxy-scyllo-inosamine + NADP(+) = 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADPH"}
{"X":35731,"RHEA_ID":33880,"DIRECTION":"LR","MASTER_ID":33879,"metacyc":"RXN-13118","compounds":"2-deoxy-scyllo-inosamine + NADP(+) => 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADPH"}
{"X":35732,"RHEA_ID":33881,"compounds":"3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADPH => 2-deoxy-scyllo-inosamine + NADP(+)"}
{"X":35733,"RHEA_ID":37199,"compounds":"(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphate = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":35734,"RHEA_ID":33883,"DIRECTION":"UN","MASTER_ID":33883,"ec":"1.1.1.329","compounds":"2-deoxy-scyllo-inosamine + NAD(+) = 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADH"}
{"X":35735,"RHEA_ID":33884,"DIRECTION":"LR","MASTER_ID":33883,"metacyc":"RXN-13118","compounds":"2-deoxy-scyllo-inosamine + NAD(+) => 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADH"}
{"X":35736,"RHEA_ID":33885,"compounds":"3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADH => 2-deoxy-scyllo-inosamine + NAD(+)"}
{"X":35737,"RHEA_ID":53800,"compounds":"lithocholoyl-CoA + ursodeoxycholate = lithocholate + ursodeoxycholoyl-CoA"}
{"X":35738,"RHEA_ID":33887,"DIRECTION":"UN","MASTER_ID":33887,"ec":"1.1.1.331","compounds":"(-)-secoisolariciresinol + 2 NAD(+) = (-)-matairesinol + 2 H(+) + 2 NADH"}
{"X":35739,"RHEA_ID":33888,"compounds":"(-)-secoisolariciresinol + 2 NAD(+) => (-)-matairesinol + 2 H(+) + 2 NADH"}
{"X":35740,"RHEA_ID":33889,"compounds":"(-)-matairesinol + 2 H(+) + 2 NADH => (-)-secoisolariciresinol + 2 NAD(+)"}
{"X":35741,"RHEA_ID":37207,"compounds":"(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":35742,"RHEA_ID":33891,"DIRECTION":"UN","MASTER_ID":33891,"ec":"1.1.1.332","compounds":"chanoclavine-I + NAD(+) = chanoclavine-I aldehyde + H(+) + NADH"}
{"X":35743,"RHEA_ID":33892,"DIRECTION":"LR","MASTER_ID":33891,"metacyc":"RXN-13468","compounds":"chanoclavine-I + NAD(+) => chanoclavine-I aldehyde + H(+) + NADH"}
{"X":35744,"RHEA_ID":33893,"compounds":"chanoclavine-I aldehyde + H(+) + NADH => chanoclavine-I + NAD(+)"}
{"X":35745,"RHEA_ID":53808,"compounds":"cholestanol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":35746,"RHEA_ID":33895,"DIRECTION":"UN","MASTER_ID":33895,"ec":"1.1.1.333","compounds":"NAD(+) + trans,octa-cis-decaprenylphospho-beta-D-arabinofuranose = H(+) + NADH + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose"}
{"X":35747,"RHEA_ID":33896,"compounds":"NAD(+) + trans,octa-cis-decaprenylphospho-beta-D-arabinofuranose => H(+) + NADH + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose"}
{"X":35748,"RHEA_ID":33897,"DIRECTION":"RL","MASTER_ID":33895,"metacyc":"RXN-11081","compounds":"H(+) + NADH + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose => NAD(+) + trans,octa-cis-decaprenylphospho-beta-D-arabinofuranose"}
{"X":35749,"RHEA_ID":37219,"compounds":"A + D-valine + H2O = 3-methyl-2-oxobutanoate + AH2 + NH4(+)"}
{"X":35750,"RHEA_ID":33899,"DIRECTION":"UN","MASTER_ID":33899,"ec":"1.1.98.3","compounds":"FAD + H(+) + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose = FADH2 + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose"}
{"X":35751,"RHEA_ID":33900,"DIRECTION":"LR","MASTER_ID":33899,"metacyc":"RXN-11080","compounds":"FAD + H(+) + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose => FADH2 + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose"}
{"X":35752,"RHEA_ID":33901,"compounds":"FADH2 + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose => FAD + H(+) + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose"}
{"X":35753,"RHEA_ID":53816,"compounds":"hydrogen sulfide + O-succinyl-L-serine = L-cysteine + succinate"}
{"X":35754,"RHEA_ID":33903,"DIRECTION":"UN","MASTER_ID":33903,"ec":"1.4.3.24","compounds":"H2O + O2 + pseudooxynicotine = 4-oxo-4-(pyridin-3-yl)butanal + H2O2 + methylamine"}
{"X":35755,"RHEA_ID":33904,"DIRECTION":"LR","MASTER_ID":33903,"ecocyc":"RXN-13088","compounds":"H2O + O2 + pseudooxynicotine => 4-oxo-4-(pyridin-3-yl)butanal + H2O2 + methylamine"}
{"X":35756,"RHEA_ID":33905,"compounds":"4-oxo-4-(pyridin-3-yl)butanal + H2O2 + methylamine => H2O + O2 + pseudooxynicotine"}
{"X":35757,"RHEA_ID":37227,"compounds":"(E,E)-sorbate + H(+) = (E)-1,3-pentadiene + CO2"}
{"X":35758,"RHEA_ID":33907,"DIRECTION":"UN","MASTER_ID":33907,"ec":"1.5.3.19","compounds":"4-(methylamino)butanoate + H2O + O2 = 4-aminobutanoate + formaldehyde + H2O2"}
{"X":35759,"RHEA_ID":33908,"DIRECTION":"LR","MASTER_ID":33907,"metacyc":"RXN-13067","compounds":"4-(methylamino)butanoate + H2O + O2 => 4-aminobutanoate + formaldehyde + H2O2"}
{"X":35760,"RHEA_ID":33909,"compounds":"4-aminobutanoate + formaldehyde + H2O2 => 4-(methylamino)butanoate + H2O + O2"}
{"X":35761,"RHEA_ID":53824,"compounds":"NAD(+) + taurochenodeoxycholate = 7-oxo-taurolithocholate + H(+) + NADH"}
{"X":35762,"RHEA_ID":33911,"DIRECTION":"UN","MASTER_ID":33911,"ec":"1.5.3.20","compounds":"an N-alkylglycine + H2O + O2 = an alkylamine + glyoxylate + H2O2"}
{"X":35763,"RHEA_ID":33912,"DIRECTION":"LR","MASTER_ID":33911,"metacyc":"RXN-13339","compounds":"an N-alkylglycine + H2O + O2 => an alkylamine + glyoxylate + H2O2"}
{"X":35764,"RHEA_ID":33913,"compounds":"an alkylamine + glyoxylate + H2O2 => an N-alkylglycine + H2O + O2"}
{"X":35765,"RHEA_ID":53828,"compounds":"2-oxoglutarate + a 5-hydroxymethyl-2'-deoxycytidine in DNA + O2 = a 5-formyl-2'-deoxycytidine in DNA + CO2 + H2O + succinate"}
{"X":35766,"RHEA_ID":33915,"DIRECTION":"UN","MASTER_ID":33915,"ec":"1.5.3.21","compounds":"4-(methylamino)butanoate + H2O + O2 = H2O2 + methylamine + succinate semialdehyde"}
{"X":35767,"RHEA_ID":33916,"DIRECTION":"LR","MASTER_ID":33915,"metacyc":"RXN-13065","compounds":"4-(methylamino)butanoate + H2O + O2 => H2O2 + methylamine + succinate semialdehyde"}
{"X":35768,"RHEA_ID":33917,"compounds":"H2O2 + methylamine + succinate semialdehyde => 4-(methylamino)butanoate + H2O + O2"}
{"X":35769,"RHEA_ID":37243,"compounds":"(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + CO2 + CoA"}
{"X":35770,"RHEA_ID":33919,"compounds":"H(+) + lanosterol + NADPH = 24,25-dihydrolanosterol + NADP(+)"}
{"X":35771,"RHEA_ID":33920,"compounds":"H(+) + lanosterol + NADPH => 24,25-dihydrolanosterol + NADP(+)"}
{"X":35772,"RHEA_ID":33921,"compounds":"24,25-dihydrolanosterol + NADP(+) => H(+) + lanosterol + NADPH"}
{"X":35773,"RHEA_ID":37247,"compounds":"H2O + thymidine 3'-monophosphate = phosphate + thymidine"}
{"X":35774,"RHEA_ID":33923,"DIRECTION":"UN","MASTER_ID":33923,"ec":"1.14.14.108","compounds":"(1R,4R)-5-oxo-1,2-campholide = [(1R)-2,2,3-trimethyl-2-oxocyclopent-3-en-1-yl]acetate + H(+)"}
{"X":35775,"RHEA_ID":33924,"DIRECTION":"LR","MASTER_ID":33923,"metacyc":"R544-RXN","compounds":"(1R,4R)-5-oxo-1,2-campholide => [(1R)-2,2,3-trimethyl-2-oxocyclopent-3-en-1-yl]acetate + H(+)"}
{"X":35776,"RHEA_ID":33925,"compounds":"[(1R)-2,2,3-trimethyl-2-oxocyclopent-3-en-1-yl]acetate + H(+) => (1R,4R)-5-oxo-1,2-campholide"}
{"X":35777,"RHEA_ID":37251,"compounds":"cysteamine S-phosphate + H2O = cysteamine + phosphate"}
{"X":35778,"RHEA_ID":33927,"DIRECTION":"UN","MASTER_ID":33927,"ec":"1.14.13.163","compounds":"4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 H(+) + 2 NADH + O2 = 2,5-dihydroxypyridine + H2O + 2 NAD(+) + succinate semialdehyde"}
{"X":35779,"RHEA_ID":33928,"DIRECTION":"LR","MASTER_ID":33927,"metacyc":"RXN-13081","compounds":"4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 H(+) + 2 NADH + O2 => 2,5-dihydroxypyridine + H2O + 2 NAD(+) + succinate semialdehyde"}
{"X":35780,"RHEA_ID":33929,"compounds":"2,5-dihydroxypyridine + H2O + 2 NAD(+) + succinate semialdehyde => 4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 H(+) + 2 NADH + O2"}
{"X":35781,"RHEA_ID":37255,"compounds":"A + D-asparagine + H2O = 2-oxosuccinamate + AH2 + NH4(+)"}
{"X":35782,"RHEA_ID":33931,"DIRECTION":"UN","MASTER_ID":33931,"ec":"1.13.11.65","compounds":"all-trans-zeaxanthin + O2 = (3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal"}
{"X":35783,"RHEA_ID":33932,"DIRECTION":"LR","MASTER_ID":33931,"metacyc":"RXN-13355","compounds":"all-trans-zeaxanthin + O2 => (3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal"}
{"X":35784,"RHEA_ID":33933,"compounds":"(3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal => all-trans-zeaxanthin + O2"}
{"X":35785,"RHEA_ID":37259,"compounds":"(2S)-2-aminobutanoate + H2O + NAD(+) = 2-oxobutanoate + H(+) + NADH + NH4(+)"}
{"X":35786,"RHEA_ID":33935,"compounds":"2 N(omega)-hydroxy-L-arginine + NADH + 2 O2 = H(+) + 2 H2O + 2 L-citrulline + NAD(+) + 2 nitric oxide"}
{"X":35787,"RHEA_ID":33936,"compounds":"2 N(omega)-hydroxy-L-arginine + NADH + 2 O2 => H(+) + 2 H2O + 2 L-citrulline + NAD(+) + 2 nitric oxide"}
{"X":35788,"RHEA_ID":33937,"compounds":"H(+) + 2 H2O + 2 L-citrulline + NAD(+) + 2 nitric oxide => 2 N(omega)-hydroxy-L-arginine + NADH + 2 O2"}
{"X":35789,"RHEA_ID":53856,"compounds":"NADP(+) + ursocholate = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH"}
{"X":35790,"RHEA_ID":33939,"compounds":"H(+) + L-arginine + NADH + O2 = H2O + N(omega)-hydroxy-L-arginine + NAD(+)"}
{"X":35791,"RHEA_ID":33940,"compounds":"H(+) + L-arginine + NADH + O2 => H2O + N(omega)-hydroxy-L-arginine + NAD(+)"}
{"X":35792,"RHEA_ID":33941,"compounds":"H2O + N(omega)-hydroxy-L-arginine + NAD(+) => H(+) + L-arginine + NADH + O2"}
{"X":35793,"RHEA_ID":43869,"compounds":"a 1-acyl-sn-glycero-3-phosphoethanolamine(in) => a 1-acyl-sn-glycero-3-phosphoethanolamine(out)"}
{"X":35794,"RHEA_ID":33943,"compounds":"H(+) + 2 L-arginine + 3 NADH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NAD(+) + 2 nitric oxide"}
{"X":35795,"RHEA_ID":33944,"compounds":"H(+) + 2 L-arginine + 3 NADH + 4 O2 => 4 H2O + 2 L-citrulline + 3 NAD(+) + 2 nitric oxide"}
{"X":35796,"RHEA_ID":33945,"compounds":"4 H2O + 2 L-citrulline + 3 NAD(+) + 2 nitric oxide => H(+) + 2 L-arginine + 3 NADH + 4 O2"}
{"X":35797,"RHEA_ID":37271,"compounds":"ATP + H2O + L-alanyl-L-glutamine(out) = ADP + H(+) + L-alanyl-L-glutamine(in) + phosphate"}
{"X":35798,"RHEA_ID":33947,"DIRECTION":"UN","MASTER_ID":33947,"ec":"2.4.1.283","compounds":"2-deoxystreptamine + UDP-N-acetyl-alpha-D-glucosamine = 2'-N-acetylparomamine + H(+) + UDP"}
{"X":35799,"RHEA_ID":33948,"DIRECTION":"LR","MASTER_ID":33947,"metacyc":"RXN-13122","compounds":"2-deoxystreptamine + UDP-N-acetyl-alpha-D-glucosamine => 2'-N-acetylparomamine + H(+) + UDP"}
{"X":35800,"RHEA_ID":33949,"compounds":"2'-N-acetylparomamine + H(+) + UDP => 2-deoxystreptamine + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":35801,"RHEA_ID":37275,"compounds":"H2O + L-alanyl-L-glutamine = L-alanine + L-glutamine"}
{"X":35802,"RHEA_ID":33951,"DIRECTION":"UN","MASTER_ID":33951,"ec":"2.4.1.285","compounds":"ribostamycin + UDP-N-acetyl-alpha-D-glucosamine = 2'''-acetyl-6'''-hydroxyneomycin C + H(+) + UDP"}
{"X":35803,"RHEA_ID":33952,"DIRECTION":"LR","MASTER_ID":33951,"metacyc":"RXN-13176","compounds":"ribostamycin + UDP-N-acetyl-alpha-D-glucosamine => 2'''-acetyl-6'''-hydroxyneomycin C + H(+) + UDP"}
{"X":35804,"RHEA_ID":33953,"compounds":"2'''-acetyl-6'''-hydroxyneomycin C + H(+) + UDP => ribostamycin + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":35805,"RHEA_ID":37279,"compounds":"ATP + H2O + L-alanyl-L-histidine(out) = ADP + H(+) + L-alanyl-L-histidine(in) + phosphate"}
{"X":35806,"RHEA_ID":33955,"DIRECTION":"UN","MASTER_ID":33955,"ec":"2.4.1.202","compounds":"DIBOA + UDP-alpha-D-glucose = DIBOA beta-D-glucoside + H(+) + UDP"}
{"X":35807,"RHEA_ID":33956,"DIRECTION":"LR","MASTER_ID":33955,"metacyc":"RXN-7021","compounds":"DIBOA + UDP-alpha-D-glucose => DIBOA beta-D-glucoside + H(+) + UDP"}
{"X":35808,"RHEA_ID":33957,"compounds":"DIBOA beta-D-glucoside + H(+) + UDP => DIBOA + UDP-alpha-D-glucose"}
{"X":35809,"RHEA_ID":53876,"compounds":"a cytidine in tRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in tRNA + CoA + H(+) + phosphate"}
{"X":35810,"RHEA_ID":33959,"DIRECTION":"UN","MASTER_ID":33959,"ec":"2.6.1.95","compounds":"2-oxoglutarate + neomycin C = 6'''-deamino-6'''-oxoneomycin C + L-glutamate"}
{"X":35811,"RHEA_ID":33960,"compounds":"2-oxoglutarate + neomycin C => 6'''-deamino-6'''-oxoneomycin C + L-glutamate"}
{"X":35812,"RHEA_ID":33961,"compounds":"6'''-deamino-6'''-oxoneomycin C + L-glutamate => 2-oxoglutarate + neomycin C"}
{"X":35813,"RHEA_ID":53880,"DIRECTION":"UN","MASTER_ID":53880,"ec":"2.4.1.347","compounds":"ADP-alpha-D-glucose + D-glucose 6-phosphate = ADP + alpha,alpha-trehalose 6-phosphate + H(+)"}
{"X":35814,"RHEA_ID":33963,"DIRECTION":"UN","MASTER_ID":33963,"ec":"2.7.4.26","compounds":"ATP + isopentenyl phosphate = ADP + isopentenyl diphosphate"}
{"X":35815,"RHEA_ID":33964,"DIRECTION":"LR","MASTER_ID":33963,"metacyc":"RXN-10068","compounds":"ATP + isopentenyl phosphate => ADP + isopentenyl diphosphate"}
{"X":35816,"RHEA_ID":33965,"compounds":"ADP + isopentenyl diphosphate => ATP + isopentenyl phosphate"}
{"X":35817,"RHEA_ID":53884,"compounds":"CDP-alpha-D-glucose + D-glucose 6-phosphate = alpha,alpha-trehalose 6-phosphate + CDP + H(+)"}
{"X":35818,"RHEA_ID":43894,"compounds":"[sulfur carrier]-SH + L-alanine => [sulfur carrier]-H + L-cysteine"}
{"X":35819,"RHEA_ID":33968,"DIRECTION":"LR","MASTER_ID":33967,"metacyc":"RXN-13371","compounds":"2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H2O => 3-maleylpyruvate + H(+)"}
{"X":35820,"RHEA_ID":33969,"compounds":"3-maleylpyruvate + H(+) => 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H2O"}
{"X":35821,"RHEA_ID":43897,"compounds":"3beta-hydroxy-5alpha-androstan-17-one + O2 + reduced [NADPH--hemoprotein reductase] => 3beta,7alpha-dihydroxy-5alpha-androstan-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":35822,"RHEA_ID":33971,"DIRECTION":"UN","MASTER_ID":33971,"ec":"3.1.3.88","compounds":"5''-phosphoribostamycin + H2O = phosphate + ribostamycin"}
{"X":35823,"RHEA_ID":33972,"DIRECTION":"LR","MASTER_ID":33971,"metacyc":"RXN-13204","compounds":"5''-phosphoribostamycin + H2O => phosphate + ribostamycin"}
{"X":35824,"RHEA_ID":33973,"compounds":"phosphate + ribostamycin => 5''-phosphoribostamycin + H2O"}
{"X":35825,"RHEA_ID":53892,"DIRECTION":"UN","MASTER_ID":53892,"ec":"1.8.3.5","compounds":"an S-prenyl-L-cysteine + H2O + O2 = a prenal + H2O2 + L-cysteine"}
{"X":35826,"RHEA_ID":43902,"compounds":"beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalpatein + H(+) => dalpatein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O"}
{"X":35827,"RHEA_ID":33976,"DIRECTION":"LR","MASTER_ID":33975,"metacyc":"RXN-7082","compounds":"DIMBOA beta-D-glucoside + H2O => D-glucose + DIMBOA"}
{"X":35828,"RHEA_ID":33977,"compounds":"D-glucose + DIMBOA => DIMBOA beta-D-glucoside + H2O"}
{"X":35829,"RHEA_ID":43905,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol => all-trans-retinyl hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":35830,"RHEA_ID":43906,"compounds":"all-trans-retinyl hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol"}
{"X":35831,"RHEA_ID":33980,"DIRECTION":"LR","MASTER_ID":33979,"metacyc":"RXN-13137","compounds":"DIBOA beta-D-glucoside + H2O => D-glucose + DIBOA"}
{"X":35832,"RHEA_ID":33981,"compounds":"D-glucose + DIBOA => DIBOA beta-D-glucoside + H2O"}
{"X":35833,"RHEA_ID":43909,"compounds":"beta-D-galactosyl-(1<->1)-sphing-4-enine + H2O => D-galactose + sphing-4-enine"}
{"X":35834,"RHEA_ID":43910,"compounds":"D-galactose + sphing-4-enine => beta-D-galactosyl-(1<->1)-sphing-4-enine + H2O"}
{"X":35835,"RHEA_ID":33984,"DIRECTION":"LR","MASTER_ID":33983,"metacyc":"RXN-13338","compounds":"(+)-copalyl diphosphate => diphosphate + miltiradiene"}
{"X":35836,"RHEA_ID":33985,"compounds":"diphosphate + miltiradiene => (+)-copalyl diphosphate"}
{"X":35837,"RHEA_ID":53904,"DIRECTION":"UN","MASTER_ID":53904,"ec":"2.7.11.26","compounds":"[tau protein]-L-threonine + ATP = [tau protein]-O-phospho-L-threonine + ADP + H(+)"}
{"X":35838,"RHEA_ID":43914,"compounds":"(25R)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":35839,"RHEA_ID":33988,"DIRECTION":"LR","MASTER_ID":33987,"metacyc":"RXN-8512","compounds":"(+)-copalyl diphosphate => diphosphate + neoabietadiene"}
{"X":35840,"RHEA_ID":33989,"compounds":"diphosphate + neoabietadiene => (+)-copalyl diphosphate"}
{"X":35841,"RHEA_ID":53908,"compounds":"(2E)-butenoyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-(2E)-butenoyl-L-lysyl-[protein]"}
{"X":35842,"RHEA_ID":33991,"DIRECTION":"UN","MASTER_ID":33991,"ec":"4.2.3.133","compounds":"(2E,6E)-farnesyl diphosphate = alpha-copaene + diphosphate"}
{"X":35843,"RHEA_ID":33992,"DIRECTION":"LR","MASTER_ID":33991,"metacyc":"RXN-8416","compounds":"(2E,6E)-farnesyl diphosphate => alpha-copaene + diphosphate"}
{"X":35844,"RHEA_ID":33993,"compounds":"alpha-copaene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":35845,"RHEA_ID":53912,"compounds":"butanoyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-butanoyl-L-lysyl-[protein]"}
{"X":35846,"RHEA_ID":43922,"compounds":"(25R)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (25R)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":35847,"RHEA_ID":33996,"DIRECTION":"LR","MASTER_ID":33995,"metacyc":"RXN-13218","compounds":"gamma-L-glutamyl-butirosin B => 5-oxo-L-proline + butirosin B"}
{"X":35848,"RHEA_ID":33997,"compounds":"5-oxo-L-proline + butirosin B => gamma-L-glutamyl-butirosin B"}
{"X":35849,"RHEA_ID":53916,"compounds":"an acyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acyl-L-lysyl-[protein]"}
{"X":35850,"RHEA_ID":43926,"compounds":"H(+) + NADH + pregn-5-ene-3,20-dione => NAD(+) + pregnenolone"}
{"X":35851,"RHEA_ID":34000,"DIRECTION":"LR","MASTER_ID":33999,"reactome":"R-HSA-195690.2","compounds":"5alpha-cholesta-8,24-dien-3beta-ol => 5alpha-cholesta-7,24-dien-3beta-ol"}
{"X":35852,"RHEA_ID":34001,"compounds":"5alpha-cholesta-7,24-dien-3beta-ol => 5alpha-cholesta-8,24-dien-3beta-ol"}
{"X":35853,"RHEA_ID":43929,"DIRECTION":"LR","MASTER_ID":43928,"reactome":"R-HSA-193052.2","compounds":"pregn-5-ene-3,20-dione => progesterone"}
{"X":35854,"RHEA_ID":43930,"compounds":"progesterone => pregn-5-ene-3,20-dione"}
{"X":35855,"RHEA_ID":34004,"compounds":"5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH + O2 => cholesta-5,7,24-trien-3beta-ol + 2 H2O + NADP(+)"}
{"X":35856,"RHEA_ID":34005,"compounds":"cholesta-5,7,24-trien-3beta-ol + 2 H2O + NADP(+) => 5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH + O2"}
{"X":35857,"RHEA_ID":43933,"compounds":"3beta-hydroxyandrost-5-en-17-one + NAD(+) => androst-5-ene-3,17-dione + H(+) + NADH"}
{"X":35858,"RHEA_ID":43934,"compounds":"androst-5-ene-3,17-dione + H(+) + NADH => 3beta-hydroxyandrost-5-en-17-one + NAD(+)"}
{"X":35859,"RHEA_ID":34008,"compounds":"cholesta-5,7,24-trien-3beta-ol + S-adenosyl-L-methionine => ergosta-5,7,24(28)-trien-3beta-ol + H(+) + S-adenosyl-L-homocysteine"}
{"X":35860,"RHEA_ID":34009,"compounds":"ergosta-5,7,24(28)-trien-3beta-ol + H(+) + S-adenosyl-L-homocysteine => cholesta-5,7,24-trien-3beta-ol + S-adenosyl-L-methionine"}
{"X":35861,"RHEA_ID":43937,"compounds":"androst-5-ene-3,17-dione => androst-4-ene-3,17-dione"}
{"X":35862,"RHEA_ID":43938,"compounds":"androst-4-ene-3,17-dione => androst-5-ene-3,17-dione"}
{"X":35863,"RHEA_ID":34012,"compounds":"ergosta-5,7,24(28)-trien-3beta-ol + 2 H2O + NADP(+) => ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2"}
{"X":35864,"RHEA_ID":34013,"compounds":"ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2 => ergosta-5,7,24(28)-trien-3beta-ol + 2 H2O + NADP(+)"}
{"X":35865,"RHEA_ID":43953,"compounds":"3,7,11,15-tetramethylhexadecanoate + H(+) + NADPH + O2 => H2O + NADP(+) + omega-hydroxy-3,7,11,15-tetramethyl-hexadecanoate"}
{"X":35866,"RHEA_ID":43954,"compounds":"H2O + NADP(+) + omega-hydroxy-3,7,11,15-tetramethyl-hexadecanoate => 3,7,11,15-tetramethylhexadecanoate + H(+) + NADPH + O2"}
{"X":35867,"RHEA_ID":34016,"compounds":"ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2 => ergosterol + 2 H2O + NADP(+)"}
{"X":35868,"RHEA_ID":34017,"compounds":"ergosterol + 2 H2O + NADP(+) => ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2"}
{"X":35869,"RHEA_ID":43957,"compounds":"15-methylhexadecanoate + H(+) + NADPH + O2 => H2O + NADP(+) + omega-hydroxy-15-methyl-hexadecanoate"}
{"X":35870,"RHEA_ID":43958,"compounds":"H2O + NADP(+) + omega-hydroxy-15-methyl-hexadecanoate => 15-methylhexadecanoate + H(+) + NADPH + O2"}
{"X":35871,"RHEA_ID":34020,"DIRECTION":"LR","MASTER_ID":34019,"metacyc":"3.1.1.23-RXN","compounds":"a 1-acylglycerol + H2O => a fatty acid + glycerol + H(+)"}
{"X":35872,"RHEA_ID":34021,"compounds":"a fatty acid + glycerol + H(+) => a 1-acylglycerol + H2O"}
{"X":35873,"RHEA_ID":43962,"compounds":"a 1-acyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA"}
{"X":35874,"RHEA_ID":34024,"compounds":"3,3'-bipyridine-2,2',5,5',6,6'-hexol + NAD(+) => (E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADH"}
{"X":35875,"RHEA_ID":34025,"DIRECTION":"RL","MASTER_ID":34023,"metacyc":"RXN-13069","compounds":"(E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADH => 3,3'-bipyridine-2,2',5,5',6,6'-hexol + NAD(+)"}
{"X":35876,"RHEA_ID":43965,"compounds":"a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA => 1-octadecanoyl-2-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}
{"X":35877,"RHEA_ID":43966,"compounds":"1-octadecanoyl-2-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA"}
{"X":35878,"RHEA_ID":34028,"compounds":"3,3'-bipyridine-2,2',5,5',6,6'-hexol + NADP(+) => (E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADPH"}
{"X":35879,"RHEA_ID":34029,"DIRECTION":"RL","MASTER_ID":34027,"metacyc":"RXN-13069","compounds":"(E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADPH => 3,3'-bipyridine-2,2',5,5',6,6'-hexol + NADP(+)"}
{"X":35880,"RHEA_ID":43969,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate"}
{"X":35881,"RHEA_ID":53949,"DIRECTION":"LR","MASTER_ID":53948,"metacyc":"RXN-13213","compounds":"ATP + holo-[BtrI ACP] + L-glutamate => ADP + gamma-L-glutamyl-[BtrI ACP] + phosphate"}
{"X":35882,"RHEA_ID":34032,"DIRECTION":"LR","MASTER_ID":34031,"metacyc":"RXN-13123","compounds":"2'-N-acetylparomamine + H2O => acetate + paromamine"}
{"X":35883,"RHEA_ID":34033,"compounds":"acetate + paromamine => 2'-N-acetylparomamine + H2O"}
{"X":35884,"RHEA_ID":43973,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => H(+) + hexadecanoate + hexadecanoyl-glycero-3-phospho-(1D-myo-inositol)"}
{"X":35885,"RHEA_ID":53953,"DIRECTION":"LR","MASTER_ID":53952,"metacyc":"RXN-13215","compounds":"4-aminobutanoyl-[BtrI ACP] + ATP + L-glutamate => 4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + ADP + H(+) + phosphate"}
{"X":35886,"RHEA_ID":34036,"DIRECTION":"LR","MASTER_ID":34035,"metacyc":"RXN-13165","compounds":"O2 + paromamine => 6'-oxoparomamine + H2O2"}
{"X":35887,"RHEA_ID":34037,"compounds":"6'-oxoparomamine + H2O2 => O2 + paromamine"}
{"X":35888,"RHEA_ID":43977,"compounds":"H(+) + hexadecanoate + NADPH + O2 => 14-hydroxyhexadecanoate + H2O + NADP(+)"}
{"X":35889,"RHEA_ID":53957,"DIRECTION":"LR","MASTER_ID":53956,"metacyc":"RXN-13214","compounds":"gamma-L-glutamyl-[BtrI ACP] + H(+) => 4-aminobutanoyl-[BtrI ACP] + CO2"}
{"X":35890,"RHEA_ID":34040,"compounds":"2-oxoglutarate + neamine => 6'-oxoparomamine + L-glutamate"}
{"X":35891,"RHEA_ID":34041,"compounds":"6'-oxoparomamine + L-glutamate => 2-oxoglutarate + neamine"}
{"X":35892,"RHEA_ID":43981,"compounds":"H(+) + hexadecanoate + NADPH + O2 => 15-hydroxyhexadecanoate + H2O + NADP(+)"}
{"X":35893,"RHEA_ID":43982,"compounds":"15-hydroxyhexadecanoate + H2O + NADP(+) => H(+) + hexadecanoate + NADPH + O2"}
{"X":35894,"RHEA_ID":34044,"DIRECTION":"LR","MASTER_ID":34043,"metacyc":"RXN-13203","compounds":"5-phospho-alpha-D-ribose 1-diphosphate + neamine => 5''-phosphoribostamycin + diphosphate"}
{"X":35895,"RHEA_ID":34045,"compounds":"5''-phosphoribostamycin + diphosphate => 5-phospho-alpha-D-ribose 1-diphosphate + neamine"}
{"X":35896,"RHEA_ID":43985,"compounds":"(2E,6E)-farnesol + H(+) + NADPH + O2 => (2E,6E)-omega-hydroxy-farnesol + H2O + NADP(+)"}
{"X":35897,"RHEA_ID":53965,"DIRECTION":"LR","MASTER_ID":53964,"metacyc":"RXN-13217","compounds":"4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + ribostamycin => gamma-L-glutamyl-butirosin B + H(+) + holo-[BtrI ACP]"}
{"X":35898,"RHEA_ID":34048,"DIRECTION":"LR","MASTER_ID":34047,"metacyc":"RXN-13174","compounds":"6'''-deamino-6'''-hydroxyneomycin C + O2 => 6'''-deamino-6'''-oxoneomycin C + H2O2"}
{"X":35899,"RHEA_ID":34049,"compounds":"6'''-deamino-6'''-oxoneomycin C + H2O2 => 6'''-deamino-6'''-hydroxyneomycin C + O2"}
{"X":35900,"RHEA_ID":43989,"compounds":"(2E,6E)-farnesyl diphosphate + H(+) + NADPH + O2 => (2E,6E)-omega-hydroxy-farnesyl diphosphate + H2O + NADP(+)"}
{"X":35901,"RHEA_ID":43990,"compounds":"(2E,6E)-omega-hydroxy-farnesyl diphosphate + H2O + NADP(+) => (2E,6E)-farnesyl diphosphate + H(+) + NADPH + O2"}
{"X":35902,"RHEA_ID":34052,"DIRECTION":"LR","MASTER_ID":34051,"metacyc":"RXN-13177","compounds":"2'''-acetyl-6'''-hydroxyneomycin C + H2O => 6'''-deamino-6'''-hydroxyneomycin C + acetate"}
{"X":35903,"RHEA_ID":34053,"compounds":"6'''-deamino-6'''-hydroxyneomycin C + acetate => 2'''-acetyl-6'''-hydroxyneomycin C + H2O"}
{"X":35904,"RHEA_ID":43993,"compounds":"(2E,6E,10E)-geranylgeraniol + H(+) + NADPH + O2 => 16-hydroxy-(2E,6E,10E)-geranylgeraniol + H2O + NADP(+)"}
{"X":35905,"RHEA_ID":53973,"compounds":"(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O => (8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate"}
{"X":35906,"RHEA_ID":34056,"compounds":"festuclavine + NAD(+) => 6,8-dimethyl-6,7-didehydroergoline + H(+) + NADH"}
{"X":35907,"RHEA_ID":34057,"DIRECTION":"RL","MASTER_ID":34055,"metacyc":"RXN-13478","compounds":"6,8-dimethyl-6,7-didehydroergoline + H(+) + NADH => festuclavine + NAD(+)"}
{"X":35908,"RHEA_ID":43997,"compounds":"2-oxoglutarate + 3-methyl fatty acyl-CoA + O2 => 2-hydroxy-3-methyl fatty acyl-CoA + CO2 + succinate"}
{"X":35909,"RHEA_ID":43998,"compounds":"2-hydroxy-3-methyl fatty acyl-CoA + CO2 + succinate => 2-oxoglutarate + 3-methyl fatty acyl-CoA + O2"}
{"X":35910,"RHEA_ID":34060,"compounds":"agroclavine + NADP(+) => didehydroagroclavine + H(+) + NADPH"}
{"X":35911,"RHEA_ID":34061,"DIRECTION":"RL","MASTER_ID":34059,"metacyc":"RXN-11390","compounds":"didehydroagroclavine + H(+) + NADPH => agroclavine + NADP(+)"}
{"X":35912,"RHEA_ID":44001,"compounds":"2-oxoglutarate + 3-methylhexadecanoyl-CoA + O2 => 2-hydroxy-3-methylhexadecanoyl-CoA + CO2 + succinate"}
{"X":35913,"RHEA_ID":53981,"compounds":"(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O => (11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate"}
{"X":35914,"RHEA_ID":34064,"DIRECTION":"LR","MASTER_ID":34063,"metacyc":"RXN-13121","compounds":"2-deoxystreptamine + UDP-alpha-D-glucose => 2'-deamino-2'-hydroxyparomamine + H(+) + UDP"}
{"X":35915,"RHEA_ID":34065,"compounds":"2'-deamino-2'-hydroxyparomamine + H(+) + UDP => 2-deoxystreptamine + UDP-alpha-D-glucose"}
{"X":35916,"RHEA_ID":44005,"compounds":"3-methyl fatty acid + ATP + CoA => 3-methyl fatty acyl-CoA + AMP + diphosphate"}
{"X":35917,"RHEA_ID":34067,"DIRECTION":"UN","MASTER_ID":34067,"ec":"2.4.2.45","compounds":"5-phospho-alpha-D-ribose 1-diphosphate + H(+) + trans,octa-cis-decaprenyl phosphate = diphosphate + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose 5-phosphate"}
{"X":35918,"RHEA_ID":44007,"compounds":"3-methyl fatty acid + ATP + CoA <=> 3-methyl fatty acyl-CoA + AMP + diphosphate"}
{"X":35919,"RHEA_ID":34069,"compounds":"diphosphate + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose 5-phosphate => 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + trans,octa-cis-decaprenyl phosphate"}
{"X":35920,"RHEA_ID":44009,"compounds":"2-methyl-branched fatty aldehyde + H2O + NAD(+) => 2-methyl fatty acid + 2 H(+) + NADH"}
{"X":35921,"RHEA_ID":44010,"compounds":"2-methyl fatty acid + 2 H(+) + NADH => 2-methyl-branched fatty aldehyde + H2O + NAD(+)"}
{"X":35922,"RHEA_ID":34072,"DIRECTION":"LR","MASTER_ID":34071,"metacyc":"RXN-6380","compounds":"trans,octa-cis-decaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine => N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol + UMP"}
{"X":35923,"RHEA_ID":34073,"compounds":"N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol + UMP => trans,octa-cis-decaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":35924,"RHEA_ID":44013,"DIRECTION":"LR","MASTER_ID":44012,"ecocyc":"PALMITOTRANS-RXN","metacyc":"PALMITOTRANS-RXN","compounds":"(9Z)-hexadecenoyl-[ACP] + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA => (9Z)-hexadecenoyl-(Kdo)2-lipid IVA + holo-[ACP]"}
{"X":35925,"RHEA_ID":34075,"DIRECTION":"UN","MASTER_ID":34075,"ec":"2.3.1.275","compounds":"an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + phosphate"}
{"X":35926,"RHEA_ID":34077,"compounds":"a 1-acyl-sn-glycero-3-phosphate + phosphate => an acyl phosphate + sn-glycerol 3-phosphate"}
{"X":35927,"RHEA_ID":34078,"compounds":"an acyl phosphate + sn-glycerol 3-phosphate <=> a 1-acyl-sn-glycero-3-phosphate + phosphate"}
{"X":35928,"RHEA_ID":34079,"compounds":"1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + ADP + H(+) = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + ATP"}
{"X":35929,"RHEA_ID":53998,"compounds":"(14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate => (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O"}
{"X":35930,"RHEA_ID":34081,"DIRECTION":"RL","MASTER_ID":34079,"ecocyc":"RXN0-5223","metacyc":"RXN0-5223","compounds":"1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + ATP => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + ADP + H(+)"}
{"X":35931,"RHEA_ID":34082,"compounds":"1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + ADP + H(+) <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + ATP"}
{"X":35932,"RHEA_ID":34083,"compounds":"a (3R)-hydroxyacyl-CoA = a (3S)-hydroxyacyl-CoA"}
{"X":35933,"RHEA_ID":44023,"compounds":"H2O + NAD(+) + octadecanal <=> 2 H(+) + NADH + octadecanoate"}
{"X":35934,"RHEA_ID":44024,"compounds":"(3R)-hydroxydodecanoyl-CoA = (2E)-dodecenoyl-CoA + H2O"}
{"X":35935,"RHEA_ID":34086,"DIRECTION":"BI","MASTER_ID":34083,"metacyc":"OHBUTYRYL-COA-EPIM-RXN","compounds":"a (3R)-hydroxyacyl-CoA <=> a (3S)-hydroxyacyl-CoA"}
{"X":35936,"RHEA_ID":34087,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + cholesterol = a 1-acyl-sn-glycero-3-phosphocholine + a cholesterol ester"}
{"X":35937,"RHEA_ID":34088,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + cholesterol => a 1-acyl-sn-glycero-3-phosphocholine + a cholesterol ester"}
{"X":35938,"RHEA_ID":44028,"DIRECTION":"UN","MASTER_ID":44028,"ec":"4.2.1.156","compounds":"L-altrarate = 5-dehydro-4-deoxy-D-glucarate + H2O"}
{"X":35939,"RHEA_ID":34091,"DIRECTION":"UN","MASTER_ID":34091,"ec":"4.2.3.134","compounds":"(5R)-5-phosphooxy-L-lysine + H2O = (S)-2-amino-6-oxohexanoate + NH4(+) + phosphate"}
{"X":35940,"RHEA_ID":34092,"DIRECTION":"LR","MASTER_ID":34091,"reactome":"R-HSA-5696408.2","compounds":"(5R)-5-phosphooxy-L-lysine + H2O => (S)-2-amino-6-oxohexanoate + NH4(+) + phosphate"}
{"X":35941,"RHEA_ID":44032,"compounds":"9,10-epoxy-(12Z)-octadecenoate + H2O = 9,10-dihydroxy-(12Z)-octadecenoate"}
{"X":35942,"RHEA_ID":37419,"compounds":"(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":35943,"RHEA_ID":34095,"DIRECTION":"UN","MASTER_ID":34095,"ec":"4.1.1.96","compounds":"carboxyspermidine + H(+) = CO2 + spermidine"}
{"X":35944,"RHEA_ID":44035,"compounds":"9,10-epoxy-(12Z)-octadecenoate + H2O <=> 9,10-dihydroxy-(12Z)-octadecenoate"}
{"X":35945,"RHEA_ID":34097,"compounds":"CO2 + spermidine => carboxyspermidine + H(+)"}
{"X":35946,"RHEA_ID":44037,"DIRECTION":"LR","MASTER_ID":44036,"metacyc":"RXN-12134","compounds":"12,13-epoxy-(9Z)-octadecenoate + H2O => 12,13-dihydroxy-(9Z)-octadecenoate"}
{"X":35947,"RHEA_ID":34099,"DIRECTION":"UN","MASTER_ID":34099,"ec":"4.1.1.96","compounds":"carboxynorspermidine + H(+) = CO2 + norspermidine"}
{"X":35948,"RHEA_ID":44039,"compounds":"12,13-epoxy-(9Z)-octadecenoate + H2O <=> 12,13-dihydroxy-(9Z)-octadecenoate"}
{"X":35949,"RHEA_ID":44040,"compounds":"14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = 14,15-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate"}
{"X":35950,"RHEA_ID":44041,"compounds":"14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O => 14,15-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate"}
{"X":35951,"RHEA_ID":34103,"DIRECTION":"UN","MASTER_ID":34103,"ec":"5.1.3.26","compounds":"N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol = N-acetyl-alpha-D-galactosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol"}
{"X":35952,"RHEA_ID":54022,"compounds":"CoA + H(+) + N(6)-propanoyl-L-lysyl-[protein] => L-lysyl-[protein] + propanoyl-CoA"}
{"X":35953,"RHEA_ID":44044,"compounds":"11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = 11,12-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate"}
{"X":35954,"RHEA_ID":34107,"compounds":"glycine + H(+) + hexadecanoyl-CoA = 1-deoxymethyl-3-dehydrosphinganine + CO2 + CoA"}
{"X":35955,"RHEA_ID":34108,"compounds":"glycine + H(+) + hexadecanoyl-CoA => 1-deoxymethyl-3-dehydrosphinganine + CO2 + CoA"}
{"X":35956,"RHEA_ID":44048,"compounds":"8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = 8,9-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate"}
{"X":35957,"RHEA_ID":34110,"compounds":"glycine + H(+) + hexadecanoyl-CoA <=> 1-deoxymethyl-3-dehydrosphinganine + CO2 + CoA"}
{"X":35958,"RHEA_ID":34111,"DIRECTION":"UN","MASTER_ID":34111,"ec":"1.5.1.43","compounds":"carboxyspermidine + H2O + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH + putrescine"}
{"X":35959,"RHEA_ID":54030,"compounds":"a Delta(14) steroid + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]"}
{"X":35960,"RHEA_ID":44052,"compounds":"alpha,alpha-trehalose + hexadecanoyl-CoA = 2-O-hexadecanoyl-alpha,alpha-trehalose + CoA"}
{"X":35961,"RHEA_ID":44053,"compounds":"alpha,alpha-trehalose + hexadecanoyl-CoA => 2-O-hexadecanoyl-alpha,alpha-trehalose + CoA"}
{"X":35962,"RHEA_ID":34115,"DIRECTION":"UN","MASTER_ID":34115,"ec":"1.5.1.43","compounds":"carboxynorspermidine + H2O + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH + propane-1,3-diamine"}
{"X":35963,"RHEA_ID":34116,"compounds":"carboxynorspermidine + H2O + NADP(+) => H(+) + L-aspartate 4-semialdehyde + NADPH + propane-1,3-diamine"}
{"X":35964,"RHEA_ID":54035,"compounds":"(6S)-10-formyltetrahydrofolate + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose <=> (6S)-5,6,7,8-tetrahydrofolate + dTDP-4-formamido-4,6-dideoxy-alpha-D-glucose + H(+)"}
{"X":35965,"RHEA_ID":44057,"compounds":"2-O-hexadecanoyl-alpha,alpha-trehalose + hexadecanoyl-CoA => 2-O,3-O-dihexadecanoyl-alpha,alpha-trehalose + CoA"}
{"X":35966,"RHEA_ID":34119,"DIRECTION":"UN","MASTER_ID":34119,"ec":"2.3.1.206","compounds":"3 H(+) + hexanoyl-CoA + 3 malonyl-CoA = 3,5,7-trioxododecanoyl-CoA + 3 CO2 + 3 CoA"}
{"X":35967,"RHEA_ID":34120,"compounds":"3 H(+) + hexanoyl-CoA + 3 malonyl-CoA => 3,5,7-trioxododecanoyl-CoA + 3 CO2 + 3 CoA"}
{"X":35968,"RHEA_ID":54039,"compounds":"[mycoredoxin]-L-cysteine + arseno-mycothiol + H(+) <=> [mycoredoxin]-S-mycothiol-L-cysteine + arsenite"}
{"X":35969,"RHEA_ID":44061,"DIRECTION":"LR","MASTER_ID":44060,"metacyc":"RXN-17318","compounds":"2-O-sulfo-alpha,alpha-trehalose + hexadecanoyl-CoA => 2-O-sulfo-2'-O-hexadecanoyl-alpha,alpha-trehalose + CoA"}
{"X":35970,"RHEA_ID":34123,"DIRECTION":"UN","MASTER_ID":34123,"ec":"4.4.1.26","compounds":"3,5,7-trioxododecanoyl-CoA = CoA + H(+) + olivetolate"}
{"X":35971,"RHEA_ID":34124,"DIRECTION":"LR","MASTER_ID":34123,"metacyc":"RXN-13612","compounds":"3,5,7-trioxododecanoyl-CoA => CoA + H(+) + olivetolate"}
{"X":35972,"RHEA_ID":44064,"compounds":"hexadecanoyl-CoA + octan-1-ol = CoA + octyl hexadecanoyl"}
{"X":35973,"RHEA_ID":44065,"compounds":"hexadecanoyl-CoA + octan-1-ol => CoA + octyl hexadecanoyl"}
{"X":35974,"RHEA_ID":34127,"DIRECTION":"UN","MASTER_ID":34127,"ec":"2.5.1.102","compounds":"(2E)-geranyl diphosphate + olivetolate = cannabigerolate + diphosphate"}
{"X":35975,"RHEA_ID":34128,"DIRECTION":"LR","MASTER_ID":34127,"metacyc":"RXN-7853","compounds":"(2E)-geranyl diphosphate + olivetolate => cannabigerolate + diphosphate"}
{"X":35976,"RHEA_ID":37454,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + eicosanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphate + CoA"}
{"X":35977,"RHEA_ID":44069,"compounds":"1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + H2O => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)"}
{"X":35978,"RHEA_ID":34131,"compounds":"neryl diphosphate + olivetolate = cannabinerolate + diphosphate"}
{"X":35979,"RHEA_ID":34132,"compounds":"neryl diphosphate + olivetolate => cannabinerolate + diphosphate"}
{"X":35980,"RHEA_ID":44072,"compounds":"1-O-alkyl-2-acyl-sn-glycerol + ATP = 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":35981,"RHEA_ID":34134,"compounds":"neryl diphosphate + olivetolate <=> cannabinerolate + diphosphate"}
{"X":35982,"RHEA_ID":34135,"DIRECTION":"UN","MASTER_ID":34135,"ec":"1.21.3.7","compounds":"cannabigerolate + O2 = Delta(9)-tetrahydrocannabinolate + H2O2"}
{"X":35983,"RHEA_ID":34136,"DIRECTION":"LR","MASTER_ID":34135,"metacyc":"RXN-7854","compounds":"cannabigerolate + O2 => Delta(9)-tetrahydrocannabinolate + H2O2"}
{"X":35984,"RHEA_ID":44076,"compounds":"ATP + CoA + pentadecanoate = AMP + diphosphate + pentadecanoyl-CoA"}
{"X":35985,"RHEA_ID":34138,"compounds":"cannabigerolate + O2 <=> Delta(9)-tetrahydrocannabinolate + H2O2"}
{"X":35986,"RHEA_ID":34139,"compounds":"Delta(9)-tetrahydrocannabinolate + H(+) = CO2 + Delta(9)-tetrahydrocannabinol"}
{"X":35987,"RHEA_ID":34140,"DIRECTION":"LR","MASTER_ID":34139,"metacyc":"RXN-7857","compounds":"Delta(9)-tetrahydrocannabinolate + H(+) => CO2 + Delta(9)-tetrahydrocannabinol"}
{"X":35988,"RHEA_ID":44080,"compounds":"ATP + CoA + undecanoate = AMP + diphosphate + undecanoyl-CoA"}
{"X":35989,"RHEA_ID":34142,"compounds":"Delta(9)-tetrahydrocannabinolate + H(+) <=> CO2 + Delta(9)-tetrahydrocannabinol"}
{"X":35990,"RHEA_ID":34143,"DIRECTION":"UN","MASTER_ID":34143,"ec":"1.21.3.7","compounds":"cannabinerolate + O2 = Delta(9)-tetrahydrocannabinolate + H2O2"}
{"X":35991,"RHEA_ID":34144,"compounds":"cannabinerolate + O2 => Delta(9)-tetrahydrocannabinolate + H2O2"}
{"X":35992,"RHEA_ID":37469,"compounds":"1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP => 1-diphospho-myo-inositol 2,3,4,5,6-pentakisphosphate + ATP + H(+)"}
{"X":35993,"RHEA_ID":34146,"compounds":"cannabinerolate + O2 <=> Delta(9)-tetrahydrocannabinolate + H2O2"}
{"X":35994,"RHEA_ID":34147,"DIRECTION":"UN","MASTER_ID":34147,"ec":"2.6.1.100","compounds":"2-deoxy-L-scyllo-inosose + L-glutamine = 2-deoxy-scyllo-inosamine + 2-oxoglutaramate"}
{"X":35995,"RHEA_ID":34148,"compounds":"2-deoxy-L-scyllo-inosose + L-glutamine => 2-deoxy-scyllo-inosamine + 2-oxoglutaramate"}
{"X":35996,"RHEA_ID":37473,"compounds":"CoA + H(+) + N-isovaleryl-L-homoserine lactone + S-methyl-5'-thioadenosine => 3-methylbutanoyl-CoA + S-adenosyl-L-methionine"}
{"X":35997,"RHEA_ID":44089,"compounds":"ATP + CoA + heptanoate => AMP + diphosphate + heptanoyl-CoA"}
{"X":35998,"RHEA_ID":34151,"DIRECTION":"UN","MASTER_ID":34151,"ec":"2.6.1.101","compounds":"3-amino-2,3-dideoxy-scyllo-inosose + L-glutamine = 2-deoxystreptamine + 2-oxoglutaramate"}
{"X":35999,"RHEA_ID":34152,"compounds":"3-amino-2,3-dideoxy-scyllo-inosose + L-glutamine => 2-deoxystreptamine + 2-oxoglutaramate"}
{"X":36000,"RHEA_ID":37477,"compounds":"1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":36001,"RHEA_ID":44093,"compounds":"ATP + CoA + nonadecanoate => AMP + diphosphate + nonadecanoyl-CoA"}
{"X":36002,"RHEA_ID":34155,"DIRECTION":"UN","MASTER_ID":34155,"ec":"2.3.1.202","compounds":"acetyl-CoA + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine = CoA + H(+) + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose"}
{"X":36003,"RHEA_ID":34156,"DIRECTION":"LR","MASTER_ID":34155,"metacyc":"RXN-10000","compounds":"acetyl-CoA + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine => CoA + H(+) + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose"}
{"X":36004,"RHEA_ID":37481,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine"}
{"X":36005,"RHEA_ID":44097,"compounds":"decan-1-ol + hexadecanoyl-CoA => CoA + decanyl hexadecanoate"}
{"X":36006,"RHEA_ID":34159,"DIRECTION":"UN","MASTER_ID":34159,"ec":"2.3.1.203","compounds":"acetyl-CoA + UDP-N-acetylbacillosamine = CoA + H(+) + UDP-N,N'-diacetylbacillosamine"}
{"X":36007,"RHEA_ID":34160,"DIRECTION":"LR","MASTER_ID":34159,"metacyc":"RXN-13253","compounds":"acetyl-CoA + UDP-N-acetylbacillosamine => CoA + H(+) + UDP-N,N'-diacetylbacillosamine"}
{"X":36008,"RHEA_ID":44100,"compounds":"H2O + NAD(+) + octanal = 2 H(+) + NADH + octanoate"}
{"X":36009,"RHEA_ID":44101,"DIRECTION":"LR","MASTER_ID":44100,"metacyc":"R222-RXN","compounds":"H2O + NAD(+) + octanal => 2 H(+) + NADH + octanoate"}
{"X":36010,"RHEA_ID":34163,"DIRECTION":"UN","MASTER_ID":34163,"ec":"1.13.11.66","compounds":"hydroquinone + O2 = (2E,4Z)-4-hydroxy-6-oxohexa-2,4-dienoate + H(+)"}
{"X":36011,"RHEA_ID":34164,"DIRECTION":"LR","MASTER_ID":34163,"metacyc":"RXN-8740","compounds":"hydroquinone + O2 => (2E,4Z)-4-hydroxy-6-oxohexa-2,4-dienoate + H(+)"}
{"X":36012,"RHEA_ID":54083,"compounds":"5-carboxymethoxyuridine(34) in tRNA + S-adenosyl-L-methionine <=> 5-methoxycarbonylmethoxyuridine(34) in tRNA + S-adenosyl-L-homocysteine"}
{"X":36013,"RHEA_ID":44105,"DIRECTION":"LR","MASTER_ID":44104,"metacyc":"RXN-16653","compounds":"decanal + H2O + NAD(+) => decanoate + 2 H(+) + NADH"}
{"X":36014,"RHEA_ID":34167,"DIRECTION":"UN","MASTER_ID":34167,"ec":"3.7.1.19","compounds":"2,6-dihydroxypseudooxynicotine + H2O = 2,6-dihydroxypyridine + 4-(methylamino)butanoate + H(+)"}
{"X":36015,"RHEA_ID":34168,"DIRECTION":"LR","MASTER_ID":34167,"metacyc":"R181-RXN","compounds":"2,6-dihydroxypseudooxynicotine + H2O => 2,6-dihydroxypyridine + 4-(methylamino)butanoate + H(+)"}
{"X":36016,"RHEA_ID":44108,"compounds":"H2O + heptanal + NAD(+) = 2 H(+) + heptanoate + NADH"}
{"X":36017,"RHEA_ID":54088,"compounds":"3,4-dihydroxyphenylacetate + H(+) + NADH + O2 = 2,4,5-trihydroxyphenylacetate + H2O + NAD(+)"}
{"X":36018,"RHEA_ID":34171,"DIRECTION":"UN","MASTER_ID":34171,"ec":"4.3.3.7","compounds":"L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O"}
{"X":36019,"RHEA_ID":34172,"compounds":"L-aspartate 4-semialdehyde + pyruvate => (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O"}
{"X":36020,"RHEA_ID":44112,"compounds":"hexadecanoyl-CoA + nonan-1-ol = CoA + nonyl hexadecanoate"}
{"X":36021,"RHEA_ID":54092,"compounds":"3,4-dihydroxyphenylacetate + H(+) + NADPH + O2 = 2,4,5-trihydroxyphenylacetate + H2O + NADP(+)"}
{"X":36022,"RHEA_ID":34175,"DIRECTION":"UN","MASTER_ID":34175,"ec":"2.3.1.208","compounds":"2-hydroxybenzoyl-CoA + malonyl-CoA = 4-hydroxycoumarin + CO2 + 2 CoA"}
{"X":36023,"RHEA_ID":34176,"DIRECTION":"LR","MASTER_ID":34175,"metacyc":"RXN-11171","compounds":"2-hydroxybenzoyl-CoA + malonyl-CoA => 4-hydroxycoumarin + CO2 + 2 CoA"}
{"X":36024,"RHEA_ID":44116,"compounds":"eicosan-1-ol + hexadecanoyl-CoA = CoA + eicosanyl hexadecanoate"}
{"X":36025,"RHEA_ID":54096,"DIRECTION":"UN","MASTER_ID":54096,"ec":"2.1.1.299","compounds":"N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":36026,"RHEA_ID":34179,"DIRECTION":"UN","MASTER_ID":34179,"ec":"3.1.1.93","compounds":"H2O + mycophenolic acid O-acyl-glucuronide = D-glucuronate + H(+) + mycophenolate"}
{"X":36027,"RHEA_ID":34180,"DIRECTION":"LR","MASTER_ID":34179,"metacyc":"RXN-13605","compounds":"H2O + mycophenolic acid O-acyl-glucuronide => D-glucuronate + H(+) + mycophenolate"}
{"X":36028,"RHEA_ID":34181,"compounds":"D-glucuronate + H(+) + mycophenolate => H2O + mycophenolic acid O-acyl-glucuronide"}
{"X":36029,"RHEA_ID":54099,"compounds":"N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":36030,"RHEA_ID":34183,"DIRECTION":"UN","MASTER_ID":34183,"ec":"2.4.1.60","compounds":"alpha-D-mannosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-beta-D-galactosyl-1-diphosphodecaprenol + CDP-alpha-D-abequose = alpha-D-Abe-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-beta-D-Gal-1-diphosphodecaprenol + CDP + H(+)"}
{"X":36031,"RHEA_ID":34184,"compounds":"alpha-D-mannosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-beta-D-galactosyl-1-diphosphodecaprenol + CDP-alpha-D-abequose => alpha-D-Abe-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-beta-D-Gal-1-diphosphodecaprenol + CDP + H(+)"}
{"X":36032,"RHEA_ID":34185,"compounds":"alpha-D-Abe-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-beta-D-Gal-1-diphosphodecaprenol + CDP + H(+) => alpha-D-mannosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-beta-D-galactosyl-1-diphosphodecaprenol + CDP-alpha-D-abequose"}
{"X":36033,"RHEA_ID":44125,"compounds":"hexadecanoyl-CoA + tetradecan-1-ol => CoA + tetradecanyl hexadecanoate"}
{"X":36034,"RHEA_ID":34187,"DIRECTION":"UN","MASTER_ID":34187,"ec":"3.7.1.14","compounds":"(2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + H(+) + succinate"}
{"X":36035,"RHEA_ID":34188,"DIRECTION":"LR","MASTER_ID":34187,"ecocyc":"MHPCHYDROL-RXN","metacyc":"MHPCHYDROL-RXN","compounds":"(2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O => (2Z)-2-hydroxypenta-2,4-dienoate + H(+) + succinate"}
{"X":36036,"RHEA_ID":34189,"compounds":"(2Z)-2-hydroxypenta-2,4-dienoate + H(+) + succinate => (2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O"}
{"X":36037,"RHEA_ID":37518,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + dodecanoyl-CoA <=> 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":36038,"RHEA_ID":34191,"DIRECTION":"UN","MASTER_ID":34191,"ec":"3.7.1.14","compounds":"(2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)"}
{"X":36039,"RHEA_ID":34192,"DIRECTION":"LR","MASTER_ID":34191,"ecocyc":"RXN-12070","metacyc":"RXN-12070","compounds":"(2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O => (2Z)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)"}
{"X":36040,"RHEA_ID":34193,"compounds":"(2Z)-2-hydroxypenta-2,4-dienoate + fumarate + H(+) => (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O"}
{"X":36041,"RHEA_ID":54109,"DIRECTION":"LR","MASTER_ID":54108,"metacyc":"RXN-18864","compounds":"(2E,6E)-farnesyl diphosphate => diphosphate + guaia-4,6-diene"}
{"X":36042,"RHEA_ID":34195,"DIRECTION":"UN","MASTER_ID":34195,"ec":"1.21.3.6","compounds":"2 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + 2 H(+) + O2 = 2 aureusidin 6-O-beta-glucoside + 2 H2O"}
{"X":36043,"RHEA_ID":34196,"DIRECTION":"LR","MASTER_ID":34195,"metacyc":"RXN-3102","compounds":"2 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + 2 H(+) + O2 => 2 aureusidin 6-O-beta-glucoside + 2 H2O"}
{"X":36044,"RHEA_ID":34197,"compounds":"2 aureusidin 6-O-beta-glucoside + 2 H2O => 2 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + 2 H(+) + O2"}
{"X":36045,"RHEA_ID":37526,"compounds":"(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":36046,"RHEA_ID":34199,"DIRECTION":"UN","MASTER_ID":34199,"ec":"1.21.3.6","compounds":"2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2 = bracteatin 6-O-beta-glucoside + H2O"}
{"X":36047,"RHEA_ID":34200,"DIRECTION":"LR","MASTER_ID":34199,"metacyc":"RXN-8456","compounds":"2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2 => bracteatin 6-O-beta-glucoside + H2O"}
{"X":36048,"RHEA_ID":34201,"compounds":"bracteatin 6-O-beta-glucoside + H2O => 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2"}
{"X":36049,"RHEA_ID":54117,"DIRECTION":"LR","MASTER_ID":54116,"metacyc":"RXN-18885","compounds":"all-trans-geranylgeranyl diphosphate => diphosphate + pseudolaratriene"}
{"X":36050,"RHEA_ID":34203,"DIRECTION":"UN","MASTER_ID":34203,"ec":"1.21.3.6","compounds":"2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2 = aureusidin 6-O-beta-glucoside + H2O"}
{"X":36051,"RHEA_ID":34204,"DIRECTION":"LR","MASTER_ID":34203,"metacyc":"RXN-8454","compounds":"2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2 => aureusidin 6-O-beta-glucoside + H2O"}
{"X":36052,"RHEA_ID":34205,"compounds":"aureusidin 6-O-beta-glucoside + H2O => 2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2"}
{"X":36053,"RHEA_ID":37534,"compounds":"(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA"}
{"X":36054,"RHEA_ID":34207,"DIRECTION":"UN","MASTER_ID":34207,"ec":"2.4.1.282","compounds":"3-O-alpha-D-glucopyranosyl-L-rhamnose + phosphate = beta-D-glucose 1-phosphate + L-rhamnopyranose"}
{"X":36055,"RHEA_ID":34208,"compounds":"3-O-alpha-D-glucopyranosyl-L-rhamnose + phosphate => beta-D-glucose 1-phosphate + L-rhamnopyranose"}
{"X":36056,"RHEA_ID":34209,"compounds":"beta-D-glucose 1-phosphate + L-rhamnopyranose => 3-O-alpha-D-glucopyranosyl-L-rhamnose + phosphate"}
{"X":36057,"RHEA_ID":37538,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA"}
{"X":36058,"RHEA_ID":34211,"DIRECTION":"UN","MASTER_ID":34211,"ec":"1.1.1.334","compounds":"ecgonine methyl ester + NADP(+) = ecgonone methyl ester + H(+) + NADPH"}
{"X":36059,"RHEA_ID":34212,"compounds":"ecgonine methyl ester + NADP(+) => ecgonone methyl ester + H(+) + NADPH"}
{"X":36060,"RHEA_ID":34213,"compounds":"ecgonone methyl ester + H(+) + NADPH => ecgonine methyl ester + NADP(+)"}
{"X":36061,"RHEA_ID":54129,"compounds":"3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP"}
{"X":36062,"RHEA_ID":34215,"DIRECTION":"UN","MASTER_ID":34215,"ec":"1.2.1.83","compounds":"4-oxo-4-(pyridin-3-yl)butanal + H2O + NADP(+) = 4-oxo-4-(pyridin-3-yl)butanoate + 2 H(+) + NADPH"}
{"X":36063,"RHEA_ID":34216,"DIRECTION":"LR","MASTER_ID":34215,"metacyc":"RXN-13089","compounds":"4-oxo-4-(pyridin-3-yl)butanal + H2O + NADP(+) => 4-oxo-4-(pyridin-3-yl)butanoate + 2 H(+) + NADPH"}
{"X":36064,"RHEA_ID":34217,"compounds":"4-oxo-4-(pyridin-3-yl)butanoate + 2 H(+) + NADPH => 4-oxo-4-(pyridin-3-yl)butanal + H2O + NADP(+)"}
{"X":36065,"RHEA_ID":54133,"compounds":"a ribonucleoside 5'-diphosphate-alpha-D-glucose + D-glucose 6-phosphate => a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose 6-phosphate + H(+)"}
{"X":36066,"RHEA_ID":34219,"DIRECTION":"UN","MASTER_ID":34219,"ec":"1.2.1.85","compounds":"(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O + NAD(+) = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+) + NADH"}
{"X":36067,"RHEA_ID":34220,"DIRECTION":"LR","MASTER_ID":34219,"metacyc":"RXN-8527","compounds":"(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O + NAD(+) => (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+) + NADH"}
{"X":36068,"RHEA_ID":34221,"compounds":"(2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+) + NADH => (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O + NAD(+)"}
{"X":36069,"RHEA_ID":47455,"compounds":"(2E,5Z)-tetradecadienoyl-CoA + H2O <=> (3S)-hydroxy-(5Z-tetradecenoyl)-CoA"}
{"X":36070,"RHEA_ID":34223,"DIRECTION":"UN","MASTER_ID":34223,"ec":"1.5.99.14","compounds":"6-hydroxypseudooxynicotine + A + H2O = 2,6-dihydroxypseudooxynicotine + AH2"}
{"X":36071,"RHEA_ID":34224,"DIRECTION":"LR","MASTER_ID":34223,"metacyc":"R162-RXN","compounds":"6-hydroxypseudooxynicotine + A + H2O => 2,6-dihydroxypseudooxynicotine + AH2"}
{"X":36072,"RHEA_ID":34225,"compounds":"2,6-dihydroxypseudooxynicotine + AH2 => 6-hydroxypseudooxynicotine + A + H2O"}
{"X":36073,"RHEA_ID":54141,"compounds":"cytidine(49) in tRNA precursor + S-adenosyl-L-methionine => 5-methylcytidine(49) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine"}
{"X":36074,"RHEA_ID":34227,"DIRECTION":"UN","MASTER_ID":34227,"ec":"1.13.11.64","compounds":"5-nitrosalicylate + O2 = 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H(+) + nitrite"}
{"X":36075,"RHEA_ID":34228,"DIRECTION":"LR","MASTER_ID":34227,"metacyc":"RXN-13370","compounds":"5-nitrosalicylate + O2 => 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H(+) + nitrite"}
{"X":36076,"RHEA_ID":34229,"compounds":"2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H(+) + nitrite => 5-nitrosalicylate + O2"}
{"X":36077,"RHEA_ID":44169,"compounds":"dodecanoate + 2 H(+) + NADH => dodecanal + H2O + NAD(+)"}
{"X":36078,"RHEA_ID":44170,"DIRECTION":"RL","MASTER_ID":44168,"metacyc":"RXN-16654","compounds":"dodecanal + H2O + NAD(+) => dodecanoate + 2 H(+) + NADH"}
{"X":36079,"RHEA_ID":34232,"DIRECTION":"LR","MASTER_ID":34231,"metacyc":"RXN-14253","compounds":"5-nitrosalicylate + O2 => 4-nitro-6-oxohepta-2,4-dienedioate + H(+)"}
{"X":36080,"RHEA_ID":34233,"compounds":"4-nitro-6-oxohepta-2,4-dienedioate + H(+) => 5-nitrosalicylate + O2"}
{"X":36081,"RHEA_ID":54149,"compounds":"1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene => 1-hydroxy-all-trans-1,2-dihydro-neurosporene + H2O"}
{"X":36082,"RHEA_ID":44174,"compounds":"2 H(+) + NADH + tetradecanoate => H2O + NAD(+) + tetradecanal"}
{"X":36083,"RHEA_ID":34236,"DIRECTION":"LR","MASTER_ID":34235,"metacyc":"RXN-14254","compounds":"4-nitro-6-oxohepta-2,4-dienedioate => 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + nitrite"}
{"X":36084,"RHEA_ID":34237,"compounds":"2-oxo-3-(5-oxofuran-2-ylidene)propanoate + nitrite => 4-nitro-6-oxohepta-2,4-dienedioate"}
{"X":36085,"RHEA_ID":44177,"compounds":"a 2,3-diacyl-sn-glycerol + H2O => 3-acyl-sn-glycerol + a fatty acid + H(+)"}
{"X":36086,"RHEA_ID":44178,"compounds":"3-acyl-sn-glycerol + a fatty acid + H(+) => a 2,3-diacyl-sn-glycerol + H2O"}
{"X":36087,"RHEA_ID":34240,"compounds":"L-glutamate => 3-aminopentanedioate"}
{"X":36088,"RHEA_ID":34241,"compounds":"3-aminopentanedioate => L-glutamate"}
{"X":36089,"RHEA_ID":54157,"compounds":"2-oxoglutarate + [ribosomal protein uS12]-L-proline + O2 => [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + CO2 + succinate"}
{"X":36090,"RHEA_ID":44182,"compounds":"(2E)-2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein] => 2-methylpropanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":36091,"RHEA_ID":34244,"compounds":"GTP + H(+) + Mo-molybdopterin => diphosphate + Mo-molybdopterin guanine dinucleotide"}
{"X":36092,"RHEA_ID":34245,"compounds":"diphosphate + Mo-molybdopterin guanine dinucleotide => GTP + H(+) + Mo-molybdopterin"}
{"X":36093,"RHEA_ID":34246,"compounds":"GTP + H(+) + Mo-molybdopterin <=> diphosphate + Mo-molybdopterin guanine dinucleotide"}
{"X":36094,"RHEA_ID":44186,"compounds":"2-epi-5-epi-valiolone + phosphate => D-sedoheptulose 7-phosphate"}
{"X":36095,"RHEA_ID":34248,"compounds":"1-deoxymethyl-sphinganine + NADP(+) => 1-deoxymethyl-3-dehydrosphinganine + H(+) + NADPH"}
{"X":36096,"RHEA_ID":34249,"compounds":"1-deoxymethyl-3-dehydrosphinganine + H(+) + NADPH => 1-deoxymethyl-sphinganine + NADP(+)"}
{"X":36097,"RHEA_ID":34250,"compounds":"1-deoxymethyl-sphinganine + NADP(+) <=> 1-deoxymethyl-3-dehydrosphinganine + H(+) + NADPH"}
{"X":36098,"RHEA_ID":44190,"compounds":"1-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphate"}
{"X":36099,"RHEA_ID":34252,"compounds":"1-deoxysphinganine + NADP(+) => 1-deoxy-3-dehydrosphinganine + H(+) + NADPH"}
{"X":36100,"RHEA_ID":34253,"compounds":"1-deoxy-3-dehydrosphinganine + H(+) + NADPH => 1-deoxysphinganine + NADP(+)"}
{"X":36101,"RHEA_ID":44193,"compounds":"2-methylhexadecanoate + ATP + CoA => 2-methylhexadecanoyl-CoA + AMP + diphosphate"}
{"X":36102,"RHEA_ID":44194,"compounds":"2-methylhexadecanoyl-CoA + AMP + diphosphate => 2-methylhexadecanoate + ATP + CoA"}
{"X":36103,"RHEA_ID":34256,"compounds":"sporulenol => H2O + tetraprenyl-beta-curcumene"}
{"X":36104,"RHEA_ID":34257,"compounds":"H2O + tetraprenyl-beta-curcumene => sporulenol"}
{"X":36105,"RHEA_ID":54173,"compounds":"H2O + N(6)-acyl-L-lysyl-[protein] + NAD(+) => L-lysyl-[protein] + nicotinamide + O-acyl-ADP-D-ribose"}
{"X":36106,"RHEA_ID":34259,"DIRECTION":"UN","MASTER_ID":34259,"ec":"1.14.99.47","compounds":"(+)-larreatricin + AH2 + O2 = (+)-3'-hydroxylarreatricin + A + H2O"}
{"X":36107,"RHEA_ID":34260,"DIRECTION":"LR","MASTER_ID":34259,"metacyc":"RXN-13434","compounds":"(+)-larreatricin + AH2 + O2 => (+)-3'-hydroxylarreatricin + A + H2O"}
{"X":36108,"RHEA_ID":34261,"compounds":"(+)-3'-hydroxylarreatricin + A + H2O => (+)-larreatricin + AH2 + O2"}
{"X":36109,"RHEA_ID":54177,"compounds":"a long-chain fatty aldehyde + holo-[ACP] + NADP(+) => a long-chain fatty acyl-[ACP] + H(+) + NADPH"}
{"X":36110,"RHEA_ID":44202,"compounds":"12-methyloctadecanoyl-CoA + AMP + diphosphate => 12-methyloctadecanoate + ATP + CoA"}
{"X":36111,"RHEA_ID":34264,"DIRECTION":"LR","MASTER_ID":34263,"metacyc":"RXN-11367","compounds":"dimethylallyl diphosphate + fumigaclavine A => diphosphate + fumigaclavine C"}
{"X":36112,"RHEA_ID":34265,"compounds":"diphosphate + fumigaclavine C => dimethylallyl diphosphate + fumigaclavine A"}
{"X":36113,"RHEA_ID":54181,"compounds":"a long-chain fatty aldehyde + holo-[ACP] + NAD(+) => a long-chain fatty acyl-[ACP] + H(+) + NADH"}
{"X":36114,"RHEA_ID":34267,"DIRECTION":"UN","MASTER_ID":34267,"ec":"2.3.1.205","compounds":"acetyl-CoA + fumigaclavine B = CoA + fumigaclavine A"}
{"X":36115,"RHEA_ID":34268,"DIRECTION":"LR","MASTER_ID":34267,"metacyc":"RXN-11366","compounds":"acetyl-CoA + fumigaclavine B => CoA + fumigaclavine A"}
{"X":36116,"RHEA_ID":44208,"compounds":"12-methyltridecanoate + ATP + CoA = 12-methyltridecanoyl-CoA + AMP + diphosphate"}
{"X":36117,"RHEA_ID":54185,"compounds":"an N-acyl-aromatic L-alpha-amino acid + H2O => a carboxylate + an aromatic L-alpha-amino acid"}
{"X":36118,"RHEA_ID":34271,"DIRECTION":"UN","MASTER_ID":34271,"ec":"3.5.99.9","compounds":"2-nitroimidazole + H2O = 1,3-dihydro-2H-imidazol-2-one + H(+) + nitrite"}
{"X":36119,"RHEA_ID":34272,"DIRECTION":"LR","MASTER_ID":34271,"metacyc":"RXN-13558","compounds":"2-nitroimidazole + H2O => 1,3-dihydro-2H-imidazol-2-one + H(+) + nitrite"}
{"X":36120,"RHEA_ID":44212,"compounds":"3-hydroxytetradecanoate + ATP + CoA = 3-hydroxytetradecanoyl-CoA + AMP + diphosphate"}
{"X":36121,"RHEA_ID":44214,"compounds":"3-hydroxytetradecanoyl-CoA + AMP + diphosphate => 3-hydroxytetradecanoate + ATP + CoA"}
{"X":36122,"RHEA_ID":34276,"DIRECTION":"LR","MASTER_ID":34275,"metacyc":"RXN-13221","compounds":"2-deoxy-scyllo-inosamine + S-adenosyl-L-methionine => 3-amino-2,3-dideoxy-scyllo-inosose + 5'-deoxyadenosine + H(+) + L-methionine"}
{"X":36123,"RHEA_ID":44216,"compounds":"12-hydroxyoctadecanoate + ATP + CoA = 12-hydroxyoctadecanoyl-CoA + AMP + diphosphate"}
{"X":36124,"RHEA_ID":44217,"compounds":"12-hydroxyoctadecanoate + ATP + CoA => 12-hydroxyoctadecanoyl-CoA + AMP + diphosphate"}
{"X":36125,"RHEA_ID":34279,"DIRECTION":"UN","MASTER_ID":34279,"ec":"1.3.1.94","compounds":"di-trans,poly-cis-dolichol + NADP(+) = di-trans,cis-polyprenol + H(+) + NADPH"}
{"X":36126,"RHEA_ID":44219,"compounds":"12-hydroxyoctadecanoate + ATP + CoA <=> 12-hydroxyoctadecanoyl-CoA + AMP + diphosphate"}
{"X":36127,"RHEA_ID":34281,"DIRECTION":"RL","MASTER_ID":34279,"metacyc":"RXN-9971","compounds":"di-trans,cis-polyprenol + H(+) + NADPH => di-trans,poly-cis-dolichol + NADP(+)"}
{"X":36128,"RHEA_ID":34282,"compounds":"di-trans,poly-cis-dolichol + NADP(+) <=> di-trans,cis-polyprenol + H(+) + NADPH"}
{"X":36129,"RHEA_ID":34283,"compounds":"2 L-tyrosine + O2 = 2 L-dopa"}
{"X":36130,"RHEA_ID":37612,"compounds":"(9Z)-octadecenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":36131,"RHEA_ID":34285,"compounds":"2 L-dopa => 2 L-tyrosine + O2"}
{"X":36132,"RHEA_ID":44225,"compounds":"16-hydroxyhexadecanoate + ATP + CoA => 16-hydroxyhexadecanoyl-CoA + AMP + diphosphate"}
{"X":36133,"RHEA_ID":34287,"DIRECTION":"UN","MASTER_ID":34287,"ec":"1.14.18.1","compounds":"2 L-dopa + O2 = 2 H2O + 2 L-dopaquinone"}
{"X":36134,"RHEA_ID":44227,"compounds":"16-hydroxyhexadecanoate + ATP + CoA <=> 16-hydroxyhexadecanoyl-CoA + AMP + diphosphate"}
{"X":36135,"RHEA_ID":34289,"compounds":"2 H2O + 2 L-dopaquinone => 2 L-dopa + O2"}
{"X":36136,"RHEA_ID":44229,"compounds":"9-decenoate + ATP + CoA => 9-decenoyl-CoA + AMP + diphosphate"}
{"X":36137,"RHEA_ID":34291,"DIRECTION":"UN","MASTER_ID":34291,"ec":"2.4.1.286","compounds":"2',4,4',6'-tetrahydroxychalcone + UDP-alpha-D-glucose = 2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP"}
{"X":36138,"RHEA_ID":44231,"compounds":"9-decenoate + ATP + CoA <=> 9-decenoyl-CoA + AMP + diphosphate"}
{"X":36139,"RHEA_ID":34293,"compounds":"2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP => 2',4,4',6'-tetrahydroxychalcone + UDP-alpha-D-glucose"}
{"X":36140,"RHEA_ID":44233,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":36141,"RHEA_ID":34295,"DIRECTION":"UN","MASTER_ID":34295,"ec":"2.4.1.286","compounds":"2',3,4,4',6'-pentahydroxychalcone + UDP-alpha-D-glucose = 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP"}
{"X":36142,"RHEA_ID":54211,"compounds":"2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2 <=> 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O"}
{"X":36143,"RHEA_ID":34297,"compounds":"2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP => 2',3,4,4',6'-pentahydroxychalcone + UDP-alpha-D-glucose"}
{"X":36144,"RHEA_ID":44237,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}
{"X":36145,"RHEA_ID":34299,"DIRECTION":"UN","MASTER_ID":34299,"ec":"2.6.1.94","compounds":"2'-deamino-2'-hydroxyneamine + 2-oxoglutarate = 2'-deamino-2'-hydroxy-6'-dehydroparomamine + L-glutamate"}
{"X":36146,"RHEA_ID":44239,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}
{"X":36147,"RHEA_ID":34301,"compounds":"2'-deamino-2'-hydroxy-6'-dehydroparomamine + L-glutamate => 2'-deamino-2'-hydroxyneamine + 2-oxoglutarate"}
{"X":36148,"RHEA_ID":44241,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol => a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + di-(9Z)-octadecenoylglycerol"}
{"X":36149,"RHEA_ID":34303,"DIRECTION":"UN","MASTER_ID":34303,"ec":"4.3.1.28","compounds":"L-lysine = L-pipecolate + NH4(+)"}
{"X":36150,"RHEA_ID":54219,"compounds":"2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2 <=> 2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O"}
{"X":36151,"RHEA_ID":34305,"compounds":"L-pipecolate + NH4(+) => L-lysine"}
{"X":36152,"RHEA_ID":44245,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-glycerol + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}
{"X":36153,"RHEA_ID":34307,"DIRECTION":"UN","MASTER_ID":34307,"ec":"1.14.13.166","compounds":"4-nitrocatechol + NADPH + O2 = 2-hydroxy-1,4-benzoquinone + H2O + NADP(+) + nitrite"}
{"X":36154,"RHEA_ID":44247,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-(9Z-octadecenoyl)-glycerol <=> 1,2-di-(9Z-octadecenoyl)-glycerol + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}
{"X":36155,"RHEA_ID":34309,"compounds":"2-hydroxy-1,4-benzoquinone + H2O + NADP(+) + nitrite => 4-nitrocatechol + NADPH + O2"}
{"X":36156,"RHEA_ID":34310,"compounds":"4-nitrocatechol + NADPH + O2 <=> 2-hydroxy-1,4-benzoquinone + H2O + NADP(+) + nitrite"}
{"X":36157,"RHEA_ID":34311,"DIRECTION":"UN","MASTER_ID":34311,"ec":"1.14.13.166","compounds":"4-nitrocatechol + NADH + O2 = 2-hydroxy-1,4-benzoquinone + H2O + NAD(+) + nitrite"}
{"X":36158,"RHEA_ID":44251,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":36159,"RHEA_ID":44252,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":36160,"RHEA_ID":34314,"compounds":"4-nitrocatechol + NADH + O2 <=> 2-hydroxy-1,4-benzoquinone + H2O + NAD(+) + nitrite"}
{"X":36161,"RHEA_ID":34327,"DIRECTION":"UN","MASTER_ID":34327,"ec":"1.14.13.167","compounds":"4-nitrophenol + H(+) + NADPH + O2 = 1,4-benzoquinone + H2O + NADP(+) + nitrite"}
{"X":36162,"RHEA_ID":34328,"DIRECTION":"LR","MASTER_ID":34327,"metacyc":"RXN-8739","compounds":"4-nitrophenol + H(+) + NADPH + O2 => 1,4-benzoquinone + H2O + NADP(+) + nitrite"}
{"X":36163,"RHEA_ID":44256,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":36164,"RHEA_ID":44257,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":36165,"RHEA_ID":34331,"DIRECTION":"UN","MASTER_ID":34331,"ec":"1.14.13.168","compounds":"H(+) + indole-3-pyruvate + NADPH + O2 = (indol-3-yl)acetate + CO2 + H2O + NADP(+)"}
{"X":36166,"RHEA_ID":44259,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":36167,"RHEA_ID":44260,"compounds":"2 H(+) + hexadecanoyl-CoA + 2 malonyl-CoA = 4-hydroxy-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA"}
{"X":36168,"RHEA_ID":44261,"compounds":"2 H(+) + hexadecanoyl-CoA + 2 malonyl-CoA => 4-hydroxy-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA"}
{"X":36169,"RHEA_ID":34335,"compounds":"cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 22R-hydroxycholesterol + H2O + 2 oxidized [adrenodoxin]"}
{"X":36170,"RHEA_ID":44263,"compounds":"2 H(+) + hexadecanoyl-CoA + 2 malonyl-CoA <=> 4-hydroxy-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA"}
{"X":36171,"RHEA_ID":44264,"compounds":"eicosanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-nonadecylpyran-2-one + 2 CO2 + 3 CoA"}
{"X":36172,"RHEA_ID":44265,"compounds":"eicosanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-nonadecylpyran-2-one + 2 CO2 + 3 CoA"}
{"X":36173,"RHEA_ID":34339,"compounds":"22R-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (20R,22R)-20,22-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin]"}
{"X":36174,"RHEA_ID":44267,"compounds":"eicosanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-nonadecylpyran-2-one + 2 CO2 + 3 CoA"}
{"X":36175,"RHEA_ID":44268,"compounds":"3 H(+) + hexadecanoyl-CoA + 3 malonyl-CoA = 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA"}
{"X":36176,"RHEA_ID":44269,"compounds":"3 H(+) + hexadecanoyl-CoA + 3 malonyl-CoA => 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA"}
{"X":36177,"RHEA_ID":34343,"compounds":"(20R,22R)-20,22-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 4-methylpentanal + 2 H2O + 2 oxidized [adrenodoxin] + pregnenolone"}
{"X":36178,"RHEA_ID":44271,"compounds":"3 H(+) + hexadecanoyl-CoA + 3 malonyl-CoA <=> 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA"}
{"X":36179,"RHEA_ID":34345,"compounds":"4-methylpentanal + 2 H2O + 2 oxidized [adrenodoxin] + pregnenolone => (20R,22R)-20,22-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}
{"X":36180,"RHEA_ID":44273,"compounds":"3 H(+) + 3 malonyl-CoA + octadecanoyl-CoA => 4-hydroxy-6-(2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA"}
{"X":36181,"RHEA_ID":34347,"DIRECTION":"UN","MASTER_ID":34347,"ec":"1.1.1.347","compounds":"geraniol + NAD(+) = geranial + H(+) + NADH"}
{"X":36182,"RHEA_ID":44275,"compounds":"3 H(+) + 3 malonyl-CoA + octadecanoyl-CoA <=> 4-hydroxy-6-(2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA"}
{"X":36183,"RHEA_ID":44276,"compounds":"eicosanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(2-oxohenicosyl)pyran-2-one + 3 CO2 + 4 CoA"}
{"X":36184,"RHEA_ID":44277,"compounds":"eicosanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(2-oxohenicosyl)pyran-2-one + 3 CO2 + 4 CoA"}
{"X":36185,"RHEA_ID":34351,"DIRECTION":"UN","MASTER_ID":34351,"ec":"1.2.1.86","compounds":"geranial + H2O + NAD(+) = geranate + 2 H(+) + NADH"}
{"X":36186,"RHEA_ID":44279,"compounds":"eicosanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(2-oxohenicosyl)pyran-2-one + 3 CO2 + 4 CoA"}
{"X":36187,"RHEA_ID":44280,"compounds":"2 H(+) + 2 malonyl-CoA + octadecanoyl-CoA = 4-hydroxy-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA"}
{"X":36188,"RHEA_ID":34354,"DIRECTION":"BI","MASTER_ID":34351,"metacyc":"RXN-11970","compounds":"geranial + H2O + NAD(+) <=> geranate + 2 H(+) + NADH"}
{"X":36189,"RHEA_ID":34359,"compounds":"a 1,2-diacylglycerol + H2O = a 2-acylglycerol + a carboxylate + H(+)"}
{"X":36190,"RHEA_ID":34360,"compounds":"a 1,2-diacylglycerol + H2O => a 2-acylglycerol + a carboxylate + H(+)"}
{"X":36191,"RHEA_ID":44284,"compounds":"2 H(+) + 2 malonyl-CoA + octanoyl-CoA = 4-hydroxy-6-heptylpyran-2-one + 2 CO2 + 3 CoA"}
{"X":36192,"RHEA_ID":34362,"compounds":"a 1,2-diacylglycerol + H2O <=> a 2-acylglycerol + a carboxylate + H(+)"}
{"X":36193,"RHEA_ID":34363,"DIRECTION":"UN","MASTER_ID":34363,"ec":"2.7.7.83","compounds":"H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-galactosamine"}
{"X":36194,"RHEA_ID":44287,"compounds":"2 H(+) + 2 malonyl-CoA + octanoyl-CoA <=> 4-hydroxy-6-heptylpyran-2-one + 2 CO2 + 3 CoA"}
{"X":36195,"RHEA_ID":44288,"compounds":"1,2-di-(9Z-octadecenoyl)-glycerol + CDP-choline = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)"}
{"X":36196,"RHEA_ID":44289,"compounds":"1,2-di-(9Z-octadecenoyl)-glycerol + CDP-choline => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)"}
{"X":36197,"RHEA_ID":34367,"compounds":"acrylamide + H2O = acrylate + NH4(+)"}
{"X":36198,"RHEA_ID":44291,"compounds":"1,2-di-(9Z-octadecenoyl)-glycerol + CDP-choline <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)"}
{"X":36199,"RHEA_ID":34369,"compounds":"acrylate + NH4(+) => acrylamide + H2O"}
{"X":36200,"RHEA_ID":34371,"DIRECTION":"UN","MASTER_ID":34371,"ec":"3.5.1.4","compounds":"H2O + indole-3-acetamide = (indol-3-yl)acetate + NH4(+)"}
{"X":36201,"RHEA_ID":44295,"compounds":"1,2-di-(9Z-octadecenoyl)-glycerol + CDP-ethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)"}
{"X":36202,"RHEA_ID":44296,"compounds":"2 H(+) + hexadecanoyl-CoA + malonyl-CoA + methylmalonyl-CoA = 4-hydroxy-5-methyl-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA"}
{"X":36203,"RHEA_ID":44297,"compounds":"2 H(+) + hexadecanoyl-CoA + malonyl-CoA + methylmalonyl-CoA => 4-hydroxy-5-methyl-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA"}
{"X":36204,"RHEA_ID":34375,"compounds":"4-guanidinobutanamide + H2O = 4-guanidinobutanoate + NH4(+)"}
{"X":36205,"RHEA_ID":44299,"compounds":"2 H(+) + hexadecanoyl-CoA + malonyl-CoA + methylmalonyl-CoA <=> 4-hydroxy-5-methyl-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA"}
{"X":36206,"RHEA_ID":44300,"compounds":"2 H(+) + malonyl-CoA + methylmalonyl-CoA + octadecanoyl-CoA = 4-hydroxy-5-methyl-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA"}
{"X":36207,"RHEA_ID":44301,"compounds":"2 H(+) + malonyl-CoA + methylmalonyl-CoA + octadecanoyl-CoA => 4-hydroxy-5-methyl-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA"}
{"X":36208,"RHEA_ID":34379,"DIRECTION":"UN","MASTER_ID":34379,"ec":"2.4.1.287","compounds":"alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 UDP-alpha-D-galactofuranose = beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 H(+) + 2 UDP"}
{"X":36209,"RHEA_ID":44303,"compounds":"2 H(+) + malonyl-CoA + methylmalonyl-CoA + octadecanoyl-CoA <=> 4-hydroxy-5-methyl-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA"}
{"X":36210,"RHEA_ID":44304,"compounds":"a 1-acyl-sn-glycero-3-phosphate + dodecanoyl-CoA = a 1-acyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":36211,"RHEA_ID":34382,"DIRECTION":"BI","MASTER_ID":34379,"metacyc":"RXN-13597","compounds":"alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 UDP-alpha-D-galactofuranose <=> beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 H(+) + 2 UDP"}
{"X":36212,"RHEA_ID":34383,"compounds":"alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + UDP-alpha-D-galactofuranose = beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + H(+) + UDP"}
{"X":36213,"RHEA_ID":44307,"compounds":"a 1-acyl-sn-glycero-3-phosphate + dodecanoyl-CoA <=> a 1-acyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":36214,"RHEA_ID":44308,"compounds":"(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phosphoethanolamine = 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":36215,"RHEA_ID":34386,"compounds":"alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + UDP-alpha-D-galactofuranose <=> beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + H(+) + UDP"}
{"X":36216,"RHEA_ID":34387,"compounds":"beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + UDP-alpha-D-galactofuranose = beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + H(+) + UDP"}
{"X":36217,"RHEA_ID":44311,"compounds":"(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":36218,"RHEA_ID":44312,"compounds":"1-tetradecanoylglycerol + H2O = glycerol + H(+) + tetradecanoate"}
{"X":36219,"RHEA_ID":34390,"compounds":"beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + UDP-alpha-D-galactofuranose <=> beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + H(+) + UDP"}
{"X":36220,"RHEA_ID":34391,"DIRECTION":"UN","MASTER_ID":34391,"ec":"2.4.1.288","compounds":"beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 UDP-alpha-D-galactofuranose = [beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->6)]14-beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 H(+) + 28 UDP"}
{"X":36221,"RHEA_ID":44315,"compounds":"1-tetradecanoylglycerol + H2O <=> glycerol + H(+) + tetradecanoate"}
{"X":36222,"RHEA_ID":34393,"compounds":"[beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->6)]14-beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 H(+) + 28 UDP => beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 UDP-alpha-D-galactofuranose"}
{"X":36223,"RHEA_ID":34394,"compounds":"beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 UDP-alpha-D-galactofuranose <=> [beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->6)]14-beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 H(+) + 28 UDP"}
{"X":36224,"RHEA_ID":34395,"DIRECTION":"UN","MASTER_ID":34395,"ec":"5.4.3.10","compounds":"L-phenylalanine = L-beta-phenylalanine"}
{"X":36225,"RHEA_ID":44319,"compounds":"1-dodecanoylglycerol + H2O <=> dodecanoate + glycerol + H(+)"}
{"X":36226,"RHEA_ID":44320,"compounds":"1-decanoylglycerol + H2O = decanoate + glycerol + H(+)"}
{"X":36227,"RHEA_ID":44321,"compounds":"1-decanoylglycerol + H2O => decanoate + glycerol + H(+)"}
{"X":36228,"RHEA_ID":34399,"DIRECTION":"UN","MASTER_ID":34399,"ec":"1.13.11.68","compounds":"9-cis-beta-carotene + O2 = 9-cis-10'-apo-beta-carotenal + beta-ionone"}
{"X":36229,"RHEA_ID":34400,"DIRECTION":"LR","MASTER_ID":34399,"metacyc":"RXN-13642","compounds":"9-cis-beta-carotene + O2 => 9-cis-10'-apo-beta-carotenal + beta-ionone"}
{"X":36230,"RHEA_ID":44324,"compounds":"1-butyrylglycerol + H2O = butanoate + glycerol + H(+)"}
{"X":36231,"RHEA_ID":44325,"compounds":"1-butyrylglycerol + H2O => butanoate + glycerol + H(+)"}
{"X":36232,"RHEA_ID":34403,"DIRECTION":"UN","MASTER_ID":34403,"ec":"1.13.11.69","compounds":"9-cis-10'-apo-beta-carotenal + 2 O2 = (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal + carlactone"}
{"X":36233,"RHEA_ID":44327,"compounds":"1-butyrylglycerol + H2O <=> butanoate + glycerol + H(+)"}
{"X":36234,"RHEA_ID":44328,"compounds":"1-octanoylglycerol + H2O = glycerol + H(+) + octanoate"}
{"X":36235,"RHEA_ID":44329,"compounds":"1-octanoylglycerol + H2O => glycerol + H(+) + octanoate"}
{"X":36236,"RHEA_ID":34407,"DIRECTION":"UN","MASTER_ID":34407,"ec":"2.7.7.84","compounds":"3 ATP = 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 diphosphate"}
{"X":36237,"RHEA_ID":44331,"compounds":"1-octanoylglycerol + H2O <=> glycerol + H(+) + octanoate"}
{"X":36238,"RHEA_ID":44332,"DIRECTION":"UN","MASTER_ID":44332,"ec":"6.3.2.49","compounds":"ATP + L-alanine + L-anticapsin = ADP + bacilysin + H(+) + phosphate"}
{"X":36239,"RHEA_ID":34411,"DIRECTION":"UN","MASTER_ID":34411,"ec":"1.21.3.8","compounds":"cannabigerolate + O2 = cannabidiolate + H2O2"}
{"X":36240,"RHEA_ID":54311,"compounds":"pseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-homocysteine"}
{"X":36241,"RHEA_ID":34413,"compounds":"cannabidiolate + H2O2 => cannabigerolate + O2"}
{"X":36242,"RHEA_ID":44337,"compounds":"an L-alpha-amino acid + ATP + L-arginine => ADP + H(+) + L-arginyl-L-alpha-amino acid + phosphate"}
{"X":36243,"RHEA_ID":34415,"DIRECTION":"UN","MASTER_ID":34415,"ec":"1.14.14.108","compounds":"(1R,4R)-bornane-2,5-dione + FMNH2 + O2 = (1R,4R)-5-oxo-1,2-campholide + FMN + H(+) + H2O"}
{"X":36244,"RHEA_ID":54323,"DIRECTION":"BI","MASTER_ID":54320,"metacyc":"RXN-16378","compounds":"2 [Fe(II)-cytochrome b5] + a Delta(7)-sterol + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a Delta(5),Delta(7)-sterol + 2 H2O"}
{"X":36245,"RHEA_ID":34417,"compounds":"(1R,4R)-5-oxo-1,2-campholide + FMN + H(+) + H2O => (1R,4R)-bornane-2,5-dione + FMNH2 + O2"}
{"X":36246,"RHEA_ID":44341,"DIRECTION":"LR","MASTER_ID":44340,"metacyc":"RXN-16290","compounds":"(S)-2,3-diaminopropanoate + ATP + fumarate => AMP + diphosphate + N(3)-fumaroyl-(S)-2,3-diaminopropanoate"}
{"X":36247,"RHEA_ID":34419,"DIRECTION":"UN","MASTER_ID":34419,"ec":"1.23.1.1","compounds":"(+)-lariciresinol + NADP(+) = (+)-pinoresinol + H(+) + NADPH"}
{"X":36248,"RHEA_ID":54327,"DIRECTION":"BI","MASTER_ID":54324,"metacyc":"RXN-16519","compounds":"a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid + 16 oxidized [2Fe-2S]-[ferredoxin] <=> a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 16 H(+) + 16 reduced [2Fe-2S]-[ferredoxin]"}
{"X":36249,"RHEA_ID":34421,"DIRECTION":"RL","MASTER_ID":34419,"metacyc":"RXN-8678","compounds":"(+)-pinoresinol + H(+) + NADPH => (+)-lariciresinol + NADP(+)"}
{"X":36250,"RHEA_ID":44345,"DIRECTION":"LR","MASTER_ID":44344,"metacyc":"RXN-16291","compounds":"ATP + L-valine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate => ADP + dapdiamide A + H(+) + phosphate"}
{"X":36251,"RHEA_ID":34423,"DIRECTION":"UN","MASTER_ID":34423,"ec":"1.23.1.2","compounds":"(-)-secoisolariciresinol + NADP(+) = (+)-lariciresinol + H(+) + NADPH"}
{"X":36252,"RHEA_ID":54331,"compounds":"2 H(+) + hexadecanoyl-[ACP] + 2 NADPH <=> hexadecan-1-ol + holo-[ACP] + 2 NADP(+)"}
{"X":36253,"RHEA_ID":44348,"DIRECTION":"UN","MASTER_ID":44348,"ec":"6.3.2.47","compounds":"ATP + L-isoleucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate = ADP + dapdiamide B + H(+) + phosphate"}
{"X":36254,"RHEA_ID":44349,"DIRECTION":"LR","MASTER_ID":44348,"metacyc":"RXN-16292","compounds":"ATP + L-isoleucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate => ADP + dapdiamide B + H(+) + phosphate"}
{"X":36255,"RHEA_ID":34427,"DIRECTION":"UN","MASTER_ID":34427,"ec":"1.23.1.3","compounds":"(-)-lariciresinol + NADP(+) = (-)-pinoresinol + H(+) + NADPH"}
{"X":36256,"RHEA_ID":54335,"compounds":"1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + CDP-choline <=> 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)"}
{"X":36257,"RHEA_ID":44352,"DIRECTION":"UN","MASTER_ID":44352,"ec":"6.3.2.47","compounds":"ATP + L-leucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate = ADP + dapdiamide C + H(+) + phosphate"}
{"X":36258,"RHEA_ID":44353,"DIRECTION":"LR","MASTER_ID":44352,"metacyc":"RXN-16293","compounds":"ATP + L-leucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate => ADP + dapdiamide C + H(+) + phosphate"}
{"X":36259,"RHEA_ID":34431,"DIRECTION":"UN","MASTER_ID":34431,"ec":"1.23.1.4","compounds":"(+)-secoisolariciresinol + NADP(+) = (-)-lariciresinol + H(+) + NADPH"}
{"X":36260,"RHEA_ID":54339,"compounds":"1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-choline <=> 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)"}
{"X":36261,"RHEA_ID":44356,"DIRECTION":"UN","MASTER_ID":44356,"ec":"5.5.1.26","metacyc":"RXN-16288","compounds":"nogalaviketone = methyl nogalonate"}
{"X":36262,"RHEA_ID":44357,"compounds":"nogalaviketone => methyl nogalonate"}
{"X":36263,"RHEA_ID":34435,"DIRECTION":"UN","MASTER_ID":34435,"ec":"2.1.1.261","compounds":"4-(3-methylbut-2-enyl)-L-tryptophan + S-adenosyl-L-methionine = 4-(3-methylbut-2-enyl)-L-abrine + H(+) + S-adenosyl-L-homocysteine"}
{"X":36264,"RHEA_ID":54343,"compounds":"1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-ethanolamine <=> 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)"}
{"X":36265,"RHEA_ID":34437,"compounds":"4-(3-methylbut-2-enyl)-L-abrine + H(+) + S-adenosyl-L-homocysteine => 4-(3-methylbut-2-enyl)-L-tryptophan + S-adenosyl-L-methionine"}
{"X":36266,"RHEA_ID":44361,"DIRECTION":"LR","MASTER_ID":44360,"ecocyc":"RXN-15216","metacyc":"RXN-15216","compounds":"(S)-4-hydroxy-2,3-pentanedione-5-phosphate => 3-hydroxy-2,4-pentanedione 5-phosphate"}
{"X":36267,"RHEA_ID":34439,"DIRECTION":"UN","MASTER_ID":34439,"ec":"2.3.1.223","compounds":"2,3-didehydroadipyl-CoA + acetyl-CoA = 3-oxo-5,6-didehydrosuberyl-CoA + CoA"}
{"X":36268,"RHEA_ID":54347,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)"}
{"X":36269,"RHEA_ID":34441,"DIRECTION":"RL","MASTER_ID":34439,"ecocyc":"RXN0-6512","metacyc":"RXN0-6512","compounds":"3-oxo-5,6-didehydrosuberyl-CoA + CoA => 2,3-didehydroadipyl-CoA + acetyl-CoA"}
{"X":36270,"RHEA_ID":44365,"compounds":"2-epi-5-epi-valiolone + ATP => 2-epi-5-epi-valiolone 7-phosphate + ADP + H(+)"}
{"X":36271,"RHEA_ID":34443,"DIRECTION":"UN","MASTER_ID":34443,"ec":"2.3.1.210","compounds":"acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose = CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + H(+)"}
{"X":36272,"RHEA_ID":34444,"DIRECTION":"LR","MASTER_ID":34443,"metacyc":"TDPFUCACTRANS-RXN","compounds":"acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose => CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + H(+)"}
{"X":36273,"RHEA_ID":44368,"compounds":"Cr(6+) + 2 NADPH + O2 = Cr(3+) + 2 H(+) + 2 NADP(+) + superoxide"}
{"X":36274,"RHEA_ID":34446,"compounds":"acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose <=> CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + H(+)"}
{"X":36275,"RHEA_ID":34447,"DIRECTION":"UN","MASTER_ID":34447,"ec":"1.1.1.339","compounds":"dTDP-6-deoxy-beta-L-talose + NAD(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADH"}
{"X":36276,"RHEA_ID":34447,"DIRECTION":"UN","MASTER_ID":34447,"ec":"1.1.1.344","compounds":"dTDP-6-deoxy-beta-L-talose + NAD(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADH"}
{"X":36277,"RHEA_ID":54356,"DIRECTION":"UN","MASTER_ID":54356,"ec":"4.1.1.72","compounds":"3-methyl-2-oxobutanoate + H(+) = 2-methylpropanal + CO2"}
{"X":36278,"RHEA_ID":34449,"DIRECTION":"RL","MASTER_ID":34447,"metacyc":"RXN-13749","compounds":"dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADH => dTDP-6-deoxy-beta-L-talose + NAD(+)"}
{"X":36279,"RHEA_ID":44374,"compounds":"Cr(3+) + 2 H(+) + 2 NAD(+) + superoxide => Cr(6+) + 2 NADH + O2"}
{"X":36280,"RHEA_ID":34451,"DIRECTION":"UN","MASTER_ID":34451,"ec":"5.1.3.25","compounds":"dTDP-6-deoxy-beta-L-talose = dTDP-beta-L-rhamnose"}
{"X":36281,"RHEA_ID":54360,"DIRECTION":"UN","MASTER_ID":54360,"ec":"4.1.1.72","compounds":"4-methyl-2-oxopentanoate + H(+) = 3-methylbutanal + CO2"}
{"X":36282,"RHEA_ID":34453,"compounds":"dTDP-beta-L-rhamnose => dTDP-6-deoxy-beta-L-talose"}
{"X":36283,"RHEA_ID":44378,"compounds":"a 1-acyl-sn-glycero-3-phosphocholine(out) => a 1-acyl-sn-glycero-3-phosphocholine(in)"}
{"X":36284,"RHEA_ID":34455,"DIRECTION":"UN","MASTER_ID":34455,"ec":"5.2.1.14","compounds":"all-trans-beta-carotene = 9-cis-beta-carotene"}
{"X":36285,"RHEA_ID":54364,"compounds":"2 acetaldehyde = acetoin"}
{"X":36286,"RHEA_ID":34457,"compounds":"9-cis-beta-carotene => all-trans-beta-carotene"}
{"X":36287,"RHEA_ID":44382,"compounds":"a ubiquinol + H(+) + S-adenosyl-L-homocysteine => a 3-demethylubiquinol + S-adenosyl-L-methionine"}
{"X":36288,"RHEA_ID":34459,"DIRECTION":"UN","MASTER_ID":34459,"ec":"4.2.3.141","compounds":"8-hydroxycopalyl diphosphate + H2O = diphosphate + sclareol"}
{"X":36289,"RHEA_ID":54368,"compounds":"acetaldehyde + H(+) + pyruvate = acetoin + CO2"}
{"X":36290,"RHEA_ID":34461,"compounds":"diphosphate + sclareol => 8-hydroxycopalyl diphosphate + H2O"}
{"X":36291,"RHEA_ID":44386,"compounds":"1-heptadecanoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA => 1-heptadecanoyl-sn-glycero-3-phosphate + dodecanoyl-CoA"}
{"X":36292,"RHEA_ID":34463,"DIRECTION":"UN","MASTER_ID":34463,"ec":"4.2.3.140","compounds":"8-hydroxycopalyl diphosphate = cis-abienol + diphosphate"}
{"X":36293,"RHEA_ID":44388,"compounds":"1-heptadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-heptadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":36294,"RHEA_ID":34465,"compounds":"cis-abienol + diphosphate => 8-hydroxycopalyl diphosphate"}
{"X":36295,"RHEA_ID":44390,"compounds":"1-heptadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA => 1-heptadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA"}
{"X":36296,"RHEA_ID":34467,"DIRECTION":"UN","MASTER_ID":34467,"ec":"4.2.3.139","compounds":"(2E,6E)-farnesyl diphosphate = diphosphate + valerena-4,7(11)-diene"}
{"X":36297,"RHEA_ID":54376,"DIRECTION":"UN","MASTER_ID":54376,"ec":"4.2.3.183","compounds":"(+)-copalyl diphosphate + H2O = diphosphate + nezukol"}
{"X":36298,"RHEA_ID":34469,"compounds":"diphosphate + valerena-4,7(11)-diene => (2E,6E)-farnesyl diphosphate"}
{"X":36299,"RHEA_ID":44394,"compounds":"1-heptadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA => 1-heptadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA"}
{"X":36300,"RHEA_ID":34471,"DIRECTION":"UN","MASTER_ID":34471,"ec":"1.3.1.95","compounds":"NAD(+) + propanoyl-CoA = acryloyl-CoA + H(+) + NADH"}
{"X":36301,"RHEA_ID":54380,"DIRECTION":"UN","MASTER_ID":54380,"ec":"4.2.3.184","compounds":"(2E,6E)-farnesyl diphosphate + H2O = 5-hydroxy-alpha-gurjunene + diphosphate"}
{"X":36302,"RHEA_ID":34473,"DIRECTION":"RL","MASTER_ID":34471,"metacyc":"RXN-8568","compounds":"acryloyl-CoA + H(+) + NADH => NAD(+) + propanoyl-CoA"}
{"X":36303,"RHEA_ID":44398,"compounds":"1-heptadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA => 1-heptadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA"}
{"X":36304,"RHEA_ID":34475,"DIRECTION":"UN","MASTER_ID":34475,"ec":"2.5.1.32","compounds":"2 all-trans-geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate"}
{"X":36305,"RHEA_ID":54384,"DIRECTION":"UN","MASTER_ID":54384,"ec":"1.3.1.22","compounds":"a 3-oxo-5alpha-steroid + NADP(+) = a 3-oxo-Delta(4)-steroid + H(+) + NADPH"}
{"X":36306,"RHEA_ID":34477,"compounds":"15-cis-phytoene + 2 diphosphate => 2 all-trans-geranylgeranyl diphosphate"}
{"X":36307,"RHEA_ID":44402,"compounds":"H(+) + S-adenosyl-L-homocysteine + ubiquinol-6 => 3-demethylubiquinol-6 + S-adenosyl-L-methionine"}
{"X":36308,"RHEA_ID":34479,"compounds":"(1R,2R,3R)-prephytoene diphosphate = 15-cis-phytoene + diphosphate"}
{"X":36309,"RHEA_ID":44404,"DIRECTION":"UN","MASTER_ID":44404,"ec":"2.1.1.64","compounds":"3-demethylubiquinol-7 + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + ubiquinol-7"}
{"X":36310,"RHEA_ID":44405,"DIRECTION":"LR","MASTER_ID":44404,"metacyc":"RXN-9229","compounds":"3-demethylubiquinol-7 + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + ubiquinol-7"}
{"X":36311,"RHEA_ID":44406,"compounds":"H(+) + S-adenosyl-L-homocysteine + ubiquinol-7 => 3-demethylubiquinol-7 + S-adenosyl-L-methionine"}
{"X":36312,"RHEA_ID":34483,"DIRECTION":"UN","MASTER_ID":34483,"ec":"2.3.1.212","compounds":"4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA = 4-hydroxybenzalacetone + 2 CO2 + 2 CoA"}
{"X":36313,"RHEA_ID":44408,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O = a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)"}
{"X":36314,"RHEA_ID":44409,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O => a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)"}
{"X":36315,"RHEA_ID":44410,"compounds":"a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O"}
{"X":36316,"RHEA_ID":34487,"DIRECTION":"UN","MASTER_ID":34487,"ec":"2.4.1.289","compounds":"dTDP-beta-L-rhamnose + N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol = alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + dTDP + H(+)"}
{"X":36317,"RHEA_ID":44412,"DIRECTION":"UN","MASTER_ID":44412,"ec":"2.1.1.64","compounds":"3-demethylubiquinol-10 + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + ubiquinol-10"}
{"X":36318,"RHEA_ID":44413,"DIRECTION":"LR","MASTER_ID":44412,"metacyc":"RXN-9237","reactome":"R-HSA-2162186.3","compounds":"3-demethylubiquinol-10 + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + ubiquinol-10"}
{"X":36319,"RHEA_ID":44414,"compounds":"H(+) + S-adenosyl-L-homocysteine + ubiquinol-10 => 3-demethylubiquinol-10 + S-adenosyl-L-methionine"}
{"X":36320,"RHEA_ID":34491,"DIRECTION":"UN","MASTER_ID":34491,"ec":"3.2.1.184","compounds":"H2O + UDP-N,N'-diacetylbacillosamine = 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H(+) + UDP"}
{"X":36321,"RHEA_ID":44416,"compounds":"1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+)"}
{"X":36322,"RHEA_ID":34493,"compounds":"2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H(+) + UDP => H2O + UDP-N,N'-diacetylbacillosamine"}
{"X":36323,"RHEA_ID":44418,"compounds":"1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O"}
{"X":36324,"RHEA_ID":34495,"DIRECTION":"UN","MASTER_ID":34495,"ec":"1.13.11.12","compounds":"(9Z,12Z,15Z)-octadecatrienoate + O2 = (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate"}
{"X":36325,"RHEA_ID":44420,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1-acyl-sn-glycero-3-phosphate + a fatty acid + H(+)"}
{"X":36326,"RHEA_ID":44421,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphate + H2O => a 1-acyl-sn-glycero-3-phosphate + a fatty acid + H(+)"}
{"X":36327,"RHEA_ID":44422,"compounds":"a 1-acyl-sn-glycero-3-phosphate + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphate + H2O"}
{"X":36328,"RHEA_ID":34499,"DIRECTION":"UN","MASTER_ID":34499,"ec":"1.14.15.11","compounds":"1-deoxypentalenate + 2 H(+) + O2 + reduced 2[4Fe-4S]-[ferredoxin] = H2O + oxidized 2[4Fe-4S]-[ferredoxin] + pentalenate"}
{"X":36329,"RHEA_ID":34500,"DIRECTION":"LR","MASTER_ID":34499,"metacyc":"RXNMETA-12666","compounds":"1-deoxypentalenate + 2 H(+) + O2 + reduced 2[4Fe-4S]-[ferredoxin] => H2O + oxidized 2[4Fe-4S]-[ferredoxin] + pentalenate"}
{"X":36330,"RHEA_ID":44425,"compounds":"an acyl-CoA + heptadecasphing-4-enine => CoA + H(+) + N-acyl-heptadecasphing-4-enine"}
{"X":36331,"RHEA_ID":44426,"compounds":"CoA + H(+) + N-acyl-heptadecasphing-4-enine => an acyl-CoA + heptadecasphing-4-enine"}
{"X":36332,"RHEA_ID":34503,"DIRECTION":"UN","MASTER_ID":34503,"ec":"4.2.3.138","compounds":"(2E,6E)-farnesyl diphosphate + H2O = (+)-epi-alpha-bisabolol + diphosphate"}
{"X":36333,"RHEA_ID":44428,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + glycerol = a 1-acyl-sn-glycero-3-phosphocholine + a 1-acylglycerol"}
{"X":36334,"RHEA_ID":44429,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + glycerol => a 1-acyl-sn-glycero-3-phosphocholine + a 1-acylglycerol"}
{"X":36335,"RHEA_ID":44430,"compounds":"a 1-acyl-sn-glycero-3-phosphocholine + a 1-acylglycerol => a 1,2-diacyl-sn-glycero-3-phosphocholine + glycerol"}
{"X":36336,"RHEA_ID":34507,"DIRECTION":"UN","MASTER_ID":34507,"ec":"2.5.1.101","compounds":"2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H2O + phosphoenolpyruvate = N,N-diacetyllegionaminate + phosphate"}
{"X":36337,"RHEA_ID":44432,"compounds":"2 a 1-acylglycerol = a 1,2-diacylglycerol + glycerol"}
{"X":36338,"RHEA_ID":44433,"compounds":"2 a 1-acylglycerol => a 1,2-diacylglycerol + glycerol"}
{"X":36339,"RHEA_ID":44434,"compounds":"a 1,2-diacylglycerol + glycerol => 2 a 1-acylglycerol"}
{"X":36340,"RHEA_ID":34511,"DIRECTION":"UN","MASTER_ID":34511,"ec":"2.4.1.290","compounds":"N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UDP-N-acetyl-alpha-D-galactosamine = H(+) + N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP"}
{"X":36341,"RHEA_ID":44436,"compounds":"a 1,2-diacylglycerol + a 1-acylglycerol = a triacylglycerol + glycerol"}
{"X":36342,"RHEA_ID":44437,"compounds":"a 1,2-diacylglycerol + a 1-acylglycerol => a triacylglycerol + glycerol"}
{"X":36343,"RHEA_ID":44438,"compounds":"a triacylglycerol + glycerol => a 1,2-diacylglycerol + a 1-acylglycerol"}
{"X":36344,"RHEA_ID":34515,"DIRECTION":"UN","MASTER_ID":34515,"ec":"2.7.8.36","compounds":"tri-trans,hepta-cis-undecaprenyl phosphate + UDP-N,N'-diacetylbacillosamine = N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UMP"}
{"X":36345,"RHEA_ID":34516,"DIRECTION":"LR","MASTER_ID":34515,"metacyc":"RXN-13269","compounds":"tri-trans,hepta-cis-undecaprenyl phosphate + UDP-N,N'-diacetylbacillosamine => N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UMP"}
{"X":36346,"RHEA_ID":44441,"compounds":"a 1,3-diacylglycerol + a 1-acylglycerol => a triacylglycerol + glycerol"}
{"X":36347,"RHEA_ID":44442,"compounds":"a triacylglycerol + glycerol => a 1,3-diacylglycerol + a 1-acylglycerol"}
{"X":36348,"RHEA_ID":34519,"DIRECTION":"UN","MASTER_ID":34519,"ec":"2.4.1.292","compounds":"N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + 3 UDP-N-acetyl-alpha-D-galactosamine = [alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + 3 H(+) + 3 UDP"}
{"X":36349,"RHEA_ID":44444,"compounds":"a 1,2-diacylglycerol + H2O = a fatty acid + a monoacylglycerol + H(+)"}
{"X":36350,"RHEA_ID":34521,"compounds":"[alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + 3 H(+) + 3 UDP => N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + 3 UDP-N-acetyl-alpha-D-galactosamine"}
{"X":36351,"RHEA_ID":34522,"compounds":"N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + 3 UDP-N-acetyl-alpha-D-galactosamine <=> [alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + 3 H(+) + 3 UDP"}
{"X":36352,"RHEA_ID":34523,"DIRECTION":"UN","MASTER_ID":34523,"ec":"2.4.1.293","compounds":"[alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose = [alpha-D-GalNAc-(1->4)]2-[beta-D-Glc-(1->3)]-[alpha-D-GalNAc-(1->4)]2-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + H(+) + UDP"}
{"X":36353,"RHEA_ID":34524,"DIRECTION":"LR","MASTER_ID":34523,"metacyc":"RXN-13277","compounds":"[alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose => [alpha-D-GalNAc-(1->4)]2-[beta-D-Glc-(1->3)]-[alpha-D-GalNAc-(1->4)]2-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + H(+) + UDP"}
{"X":36354,"RHEA_ID":44449,"compounds":"an acyl-CoA + H(+) + malonyl-[ACP] => a 3-oxoacyl-[ACP] + CO2 + CoA"}
{"X":36355,"RHEA_ID":34526,"compounds":"[alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose <=> [alpha-D-GalNAc-(1->4)]2-[beta-D-Glc-(1->3)]-[alpha-D-GalNAc-(1->4)]2-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + H(+) + UDP"}
{"X":36356,"RHEA_ID":34527,"DIRECTION":"UN","MASTER_ID":34527,"ec":"5.4.3.11","metacyc":"RXN-13649","compounds":"L-phenylalanine = (S)-3-amino-3-phenylpropanoate"}
{"X":36357,"RHEA_ID":44452,"DIRECTION":"UN","MASTER_ID":44452,"ec":"2.1.1.114","compounds":"3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate + H(+) + S-adenosyl-L-homocysteine"}
{"X":36358,"RHEA_ID":44453,"DIRECTION":"LR","MASTER_ID":44452,"metacyc":"RXN-11757","compounds":"3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L-methionine => 3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate + H(+) + S-adenosyl-L-homocysteine"}
{"X":36359,"RHEA_ID":44454,"compounds":"3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate + H(+) + S-adenosyl-L-homocysteine => 3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L-methionine"}
{"X":36360,"RHEA_ID":34531,"DIRECTION":"UN","MASTER_ID":34531,"ec":"2.3.1.209","compounds":"acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose = CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-glucose + H(+)"}
{"X":36361,"RHEA_ID":44456,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1-O-acyl-N-acylsphingosine + a 1-acyl-sn-glycero-3-phosphocholine"}
{"X":36362,"RHEA_ID":44457,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine => 1-O-acyl-N-acylsphingosine + a 1-acyl-sn-glycero-3-phosphocholine"}
{"X":36363,"RHEA_ID":44458,"compounds":"1-O-acyl-N-acylsphingosine + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine"}
{"X":36364,"RHEA_ID":34535,"compounds":"H(+) + hexadecanoyl-CoA + L-alanine = 1-deoxy-3-dehydrosphinganine + CO2 + CoA"}
{"X":36365,"RHEA_ID":44460,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycerol = a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine"}
{"X":36366,"RHEA_ID":44461,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycerol => a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine"}
{"X":36367,"RHEA_ID":34538,"compounds":"H(+) + hexadecanoyl-CoA + L-alanine <=> 1-deoxy-3-dehydrosphinganine + CO2 + CoA"}
{"X":36368,"RHEA_ID":34539,"DIRECTION":"UN","MASTER_ID":34539,"ec":"2.1.1.265","compounds":"S-adenosyl-L-methionine + tellurite = methanetellurite + S-adenosyl-L-homocysteine"}
{"X":36369,"RHEA_ID":44464,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol = 1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine"}
{"X":36370,"RHEA_ID":34541,"compounds":"methanetellurite + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + tellurite"}
{"X":36371,"RHEA_ID":34542,"compounds":"S-adenosyl-L-methionine + tellurite <=> methanetellurite + S-adenosyl-L-homocysteine"}
{"X":36372,"RHEA_ID":34543,"DIRECTION":"UN","MASTER_ID":34543,"ec":"2.4.1.291","compounds":"N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine = H(+) + N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + UDP"}
{"X":36373,"RHEA_ID":44468,"compounds":"3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine"}
{"X":36374,"RHEA_ID":44469,"compounds":"3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine => 1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine"}
{"X":36375,"RHEA_ID":34546,"compounds":"N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine <=> H(+) + N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + UDP"}
{"X":36376,"RHEA_ID":34547,"compounds":"ATP + cob(II)yrinate + H2O + L-glutamine = ADP + cob(II)yrinate c monoamide + H(+) + L-glutamate + phosphate"}
{"X":36377,"RHEA_ID":34548,"DIRECTION":"LR","MASTER_ID":34547,"metacyc":"RXN-14256","compounds":"ATP + cob(II)yrinate + H2O + L-glutamine => ADP + cob(II)yrinate c monoamide + H(+) + L-glutamate + phosphate"}
{"X":36378,"RHEA_ID":34549,"compounds":"ADP + cob(II)yrinate c monoamide + H(+) + L-glutamate + phosphate => ATP + cob(II)yrinate + H2O + L-glutamine"}
{"X":36379,"RHEA_ID":44474,"compounds":"1-O-alkyl-3-acylglycerol + a monoacyl-sn-glycero-3-phosphocholine => 1-O-alkylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine"}
{"X":36380,"RHEA_ID":34551,"compounds":"ATP + cob(II)yrinate c monoamide + H2O + L-glutamine = ADP + cob(II)yrinate a,c diamide + H(+) + L-glutamate + phosphate"}
{"X":36381,"RHEA_ID":44476,"compounds":"1-O-alkyl-2-acetylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine"}
{"X":36382,"RHEA_ID":44477,"compounds":"1-O-alkyl-2-acetylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine => a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine"}
{"X":36383,"RHEA_ID":44478,"compounds":"a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine => 1-O-alkyl-2-acetylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine"}
{"X":36384,"RHEA_ID":34555,"DIRECTION":"UN","MASTER_ID":34555,"ec":"1.1.1.337","compounds":"a (2S)-2-hydroxycarboxylate + NAD(+) = a 2-oxocarboxylate + H(+) + NADH"}
{"X":36385,"RHEA_ID":44480,"DIRECTION":"UN","MASTER_ID":44480,"ec":"2.1.1.114","compounds":"3,4-dihydroxy-5-all-trans-heptaprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-all-trans-heptaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine"}
{"X":36386,"RHEA_ID":44481,"DIRECTION":"LR","MASTER_ID":44480,"metacyc":"RXN-9287","compounds":"3,4-dihydroxy-5-all-trans-heptaprenylbenzoate + S-adenosyl-L-methionine => 3-methoxy-4-hydroxy-5-all-trans-heptaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine"}
{"X":36387,"RHEA_ID":34557,"compounds":"a 2-oxocarboxylate + H(+) + NADH => a (2S)-2-hydroxycarboxylate + NAD(+)"}
{"X":36388,"RHEA_ID":44484,"DIRECTION":"UN","MASTER_ID":44484,"ec":"2.1.1.114","compounds":"3,4-dihydroxy-5-all-trans-octaprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-all-trans-octaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine"}
{"X":36389,"RHEA_ID":44485,"DIRECTION":"LR","MASTER_ID":44484,"metacyc":"RXN-9280","compounds":"3,4-dihydroxy-5-all-trans-octaprenylbenzoate + S-adenosyl-L-methionine => 3-methoxy-4-hydroxy-5-all-trans-octaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine"}
{"X":36390,"RHEA_ID":34560,"DIRECTION":"LR","MASTER_ID":34559,"metacyc":"RXN-12658","compounds":"1-deoxy-11beta-hydroxypentalenate + NAD(+) => 1-deoxy-11-oxopentalenate + H(+) + NADH"}
{"X":36391,"RHEA_ID":34561,"compounds":"1-deoxy-11-oxopentalenate + H(+) + NADH => 1-deoxy-11beta-hydroxypentalenate + NAD(+)"}
{"X":36392,"RHEA_ID":44488,"DIRECTION":"UN","MASTER_ID":44488,"ec":"2.1.1.114","compounds":"3,4-dihydroxy-5-all-trans-nonaprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-all-trans-nonaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine"}
{"X":36393,"RHEA_ID":34563,"DIRECTION":"UN","MASTER_ID":34563,"ec":"1.1.1.341","compounds":"CDP-alpha-D-abequose + NADP(+) = CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH"}
{"X":36394,"RHEA_ID":34564,"compounds":"CDP-alpha-D-abequose + NADP(+) => CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH"}
{"X":36395,"RHEA_ID":34565,"compounds":"CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH => CDP-alpha-D-abequose + NADP(+)"}
{"X":36396,"RHEA_ID":54476,"compounds":"1-octadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + dodecanoate + H(+)"}
{"X":36397,"RHEA_ID":44493,"DIRECTION":"LR","MASTER_ID":44492,"metacyc":"RXN-9282","reactome":"R-HSA-2162193.3","compounds":"3,4-dihydroxy-5-all-trans-decaprenylbenzoate + S-adenosyl-L-methionine => 3-methoxy-4-hydroxy-5-all-trans-decaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine"}
{"X":36398,"RHEA_ID":34568,"compounds":"CDP-alpha-D-paratose + NADP(+) => CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH"}
{"X":36399,"RHEA_ID":34569,"DIRECTION":"RL","MASTER_ID":34567,"metacyc":"RXN-9159","compounds":"CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH => CDP-alpha-D-paratose + NADP(+)"}
{"X":36400,"RHEA_ID":44496,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylethanolamine = 2-(acylamino)ethyl fatty acid + a monoacyl-sn-glycero-3-phosphocholine"}
{"X":36401,"RHEA_ID":44497,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylethanolamine => 2-(acylamino)ethyl fatty acid + a monoacyl-sn-glycero-3-phosphocholine"}
{"X":36402,"RHEA_ID":34572,"compounds":"C30 botryococcene + diphosphate + NADP(+) => H(+) + NADPH + presqualene diphosphate"}
{"X":36403,"RHEA_ID":34573,"DIRECTION":"RL","MASTER_ID":34571,"metacyc":"RXN-13291","compounds":"H(+) + NADPH + presqualene diphosphate => C30 botryococcene + diphosphate + NADP(+)"}
{"X":36404,"RHEA_ID":54484,"compounds":"1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphocholine = 1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine"}
{"X":36405,"RHEA_ID":34575,"DIRECTION":"UN","MASTER_ID":34575,"ec":"1.14.19.8","compounds":"2 H(+) + O2 + pentalenolactone F + 2 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalenolactone"}
{"X":36406,"RHEA_ID":34576,"DIRECTION":"LR","MASTER_ID":34575,"metacyc":"RXN-12653","compounds":"2 H(+) + O2 + pentalenolactone F + 2 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalenolactone"}
{"X":36407,"RHEA_ID":34577,"compounds":"2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalenolactone => 2 H(+) + O2 + pentalenolactone F + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":36408,"RHEA_ID":54488,"compounds":"1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 1-heptanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-heptanoyl-sn-glycero-3-phosphocholine"}
{"X":36409,"RHEA_ID":34579,"DIRECTION":"UN","MASTER_ID":34579,"ec":"1.14.11.36","compounds":"2 2-oxoglutarate + 2 O2 + pentalenolactone D = 2 CO2 + H2O + pentalenolactone F + 2 succinate"}
{"X":36410,"RHEA_ID":34580,"DIRECTION":"LR","MASTER_ID":34579,"metacyc":"RXN-13751","compounds":"2 2-oxoglutarate + 2 O2 + pentalenolactone D => 2 CO2 + H2O + pentalenolactone F + 2 succinate"}
{"X":36411,"RHEA_ID":34581,"compounds":"2 CO2 + H2O + pentalenolactone F + 2 succinate => 2 2-oxoglutarate + 2 O2 + pentalenolactone D"}
{"X":36412,"RHEA_ID":54492,"compounds":"1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine = 1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphoethanolamine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine"}
{"X":36413,"RHEA_ID":44509,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine"}
{"X":36414,"RHEA_ID":34584,"DIRECTION":"LR","MASTER_ID":34583,"metacyc":"RXN-12660","compounds":"2-oxoglutarate + O2 + pentalenolactone D => CO2 + H2O + pentalenolactone E + succinate"}
{"X":36415,"RHEA_ID":34585,"compounds":"CO2 + H2O + pentalenolactone E + succinate => 2-oxoglutarate + O2 + pentalenolactone D"}
{"X":36416,"RHEA_ID":54496,"DIRECTION":"UN","MASTER_ID":54496,"ec":"4.2.3.185","compounds":"ent-copalyl diphosphate = diphosphate + ent-atiserene"}
{"X":36417,"RHEA_ID":44513,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphocholine"}
{"X":36418,"RHEA_ID":34588,"DIRECTION":"LR","MASTER_ID":34587,"metacyc":"RXN-12655","compounds":"2-oxoglutarate + O2 + pentalenolactone E => CO2 + pentalenolactone F + succinate"}
{"X":36419,"RHEA_ID":34589,"compounds":"CO2 + pentalenolactone F + succinate => 2-oxoglutarate + O2 + pentalenolactone E"}
{"X":36420,"RHEA_ID":54500,"DIRECTION":"UN","MASTER_ID":54500,"ec":"4.2.3.188","compounds":"(2E,6E,10E,14E)-geranylfarnesyl diphosphate = beta-geranylfarnesene + diphosphate"}
{"X":36421,"RHEA_ID":44517,"compounds":"1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoserine + H2O => (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphoserine + H(+)"}
{"X":36422,"RHEA_ID":34592,"DIRECTION":"LR","MASTER_ID":34591,"metacyc":"RXN-8767","compounds":"Co-precorrin-7 + S-adenosyl-L-methionine => Co-precorrin-8X + H(+) + S-adenosyl-L-homocysteine"}
{"X":36423,"RHEA_ID":34593,"compounds":"Co-precorrin-8X + H(+) + S-adenosyl-L-homocysteine => Co-precorrin-7 + S-adenosyl-L-methionine"}
{"X":36424,"RHEA_ID":54504,"DIRECTION":"UN","MASTER_ID":54504,"ec":"4.2.3.188","compounds":"all-trans-hexaprenyl diphosphate = beta-hexaprene + diphosphate"}
{"X":36425,"RHEA_ID":44521,"compounds":"1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":36426,"RHEA_ID":34596,"compounds":"H(+) + isopentadecanoyl-CoA + L-serine => 3-dehydro-15-methylhexadecasphinganine + CO2 + CoA"}
{"X":36427,"RHEA_ID":34597,"compounds":"3-dehydro-15-methylhexadecasphinganine + CO2 + CoA => H(+) + isopentadecanoyl-CoA + L-serine"}
{"X":36428,"RHEA_ID":34598,"compounds":"H(+) + isopentadecanoyl-CoA + L-serine <=> 3-dehydro-15-methylhexadecasphinganine + CO2 + CoA"}
{"X":36429,"RHEA_ID":54509,"DIRECTION":"LR","MASTER_ID":54508,"metacyc":"RXN-18980","compounds":"all-trans-heptaprenyl diphosphate => beta-heptaprene + diphosphate"}
{"X":36430,"RHEA_ID":34600,"compounds":"15-methylhexadecasphinganine + NADP(+) => 3-dehydro-15-methylhexadecasphinganine + H(+) + NADPH"}
{"X":36431,"RHEA_ID":34601,"compounds":"3-dehydro-15-methylhexadecasphinganine + H(+) + NADPH => 15-methylhexadecasphinganine + NADP(+)"}
{"X":36432,"RHEA_ID":34602,"compounds":"15-methylhexadecasphinganine + NADP(+) <=> 3-dehydro-15-methylhexadecasphinganine + H(+) + NADPH"}
{"X":36433,"RHEA_ID":54513,"DIRECTION":"LR","MASTER_ID":54512,"metacyc":"RXN-18976","compounds":"peregrinol diphosphate => (13R)-9,13-epoxylabd-14-ene + diphosphate"}
{"X":36434,"RHEA_ID":34604,"compounds":"15-methylhexadecasphinganine + an acyl-CoA => CoA + H(+) + N-acyl-15-methylhexadecasphinganine"}
{"X":36435,"RHEA_ID":34605,"compounds":"CoA + H(+) + N-acyl-15-methylhexadecasphinganine => 15-methylhexadecasphinganine + an acyl-CoA"}
{"X":36436,"RHEA_ID":34606,"compounds":"15-methylhexadecasphinganine + an acyl-CoA <=> CoA + H(+) + N-acyl-15-methylhexadecasphinganine"}
{"X":36437,"RHEA_ID":54517,"DIRECTION":"LR","MASTER_ID":54516,"metacyc":"RXN-11774","compounds":"8-hydroxycopalyl diphosphate => (13R)-manoyl oxide + diphosphate"}
{"X":36438,"RHEA_ID":34608,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-15-methylhexadecasphing-4-enine => a 1,2-diacyl-sn-glycerol + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine"}
{"X":36439,"RHEA_ID":34609,"compounds":"a 1,2-diacyl-sn-glycerol + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-15-methylhexadecasphing-4-enine"}
{"X":36440,"RHEA_ID":34610,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-15-methylhexadecasphing-4-enine <=> a 1,2-diacyl-sn-glycerol + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine"}
{"X":36441,"RHEA_ID":54521,"DIRECTION":"LR","MASTER_ID":54520,"metacyc":"RXN-18981","compounds":"all-trans-geranylgeranyl diphosphate => cycloaraneosene + diphosphate"}
{"X":36442,"RHEA_ID":34612,"compounds":"N-acyl-15-methylhexadecasphing-4-enine + UDP-alpha-D-glucose => H(+) + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine + UDP"}
{"X":36443,"RHEA_ID":34613,"compounds":"H(+) + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine + UDP => N-acyl-15-methylhexadecasphing-4-enine + UDP-alpha-D-glucose"}
{"X":36444,"RHEA_ID":34614,"compounds":"N-acyl-15-methylhexadecasphing-4-enine + UDP-alpha-D-glucose <=> H(+) + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine + UDP"}
{"X":36445,"RHEA_ID":54525,"compounds":"acetoacetate + H(+) + methylglyoxal => 3-hydroxyhexane-2,5-dione + CO2"}
{"X":36446,"RHEA_ID":34616,"DIRECTION":"LR","MASTER_ID":34615,"metacyc":"RXN-13856","compounds":"2-hydroxyethylphosphonate + O2 => H(+) + hydrogencarbonate + methylphosphonate"}
{"X":36447,"RHEA_ID":34617,"compounds":"H(+) + hydrogencarbonate + methylphosphonate => 2-hydroxyethylphosphonate + O2"}
{"X":36448,"RHEA_ID":34619,"DIRECTION":"UN","MASTER_ID":34619,"ec":"1.14.11.35","compounds":"1-deoxypentalenate + 2-oxoglutarate + O2 = 1-deoxy-11beta-hydroxypentalenate + CO2 + succinate"}
{"X":36449,"RHEA_ID":34620,"DIRECTION":"LR","MASTER_ID":34619,"metacyc":"RXN-12651","compounds":"1-deoxypentalenate + 2-oxoglutarate + O2 => 1-deoxy-11beta-hydroxypentalenate + CO2 + succinate"}
{"X":36450,"RHEA_ID":34621,"compounds":"1-deoxy-11beta-hydroxypentalenate + CO2 + succinate => 1-deoxypentalenate + 2-oxoglutarate + O2"}
{"X":36451,"RHEA_ID":44548,"compounds":"an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an (omega-1)-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":36452,"RHEA_ID":44549,"compounds":"an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => an (omega-1)-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":36453,"RHEA_ID":44550,"compounds":"an (omega-1)-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":36454,"RHEA_ID":34629,"compounds":"(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + H2O + 2 oxidized [adrenodoxin] => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + H(+) + O2 + 2 reduced [adrenodoxin]"}
{"X":36455,"RHEA_ID":44552,"compounds":"1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H2O = H(+) + hexadecanoate + sn-glycero-3-phospho-L-serine"}
{"X":36456,"RHEA_ID":44553,"compounds":"1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H2O => H(+) + hexadecanoate + sn-glycero-3-phospho-L-serine"}
{"X":36457,"RHEA_ID":44554,"compounds":"H(+) + hexadecanoate + sn-glycero-3-phospho-L-serine => 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H2O"}
{"X":36458,"RHEA_ID":34633,"compounds":"(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + 4 H2O + 6 oxidized [adrenodoxin] => 5beta-cholestane-3alpha,7alpha,12alpha-triol + 5 H(+) + 3 O2 + 6 reduced [adrenodoxin]"}
{"X":36459,"RHEA_ID":44556,"DIRECTION":"UN","MASTER_ID":44556,"ec":"2.5.1.39","compounds":"4-hydroxybenzoate + all-trans-hexaprenyl diphosphate = 4-hydroxy-3-all-trans-hexaprenylbenzoate + diphosphate"}
{"X":36460,"RHEA_ID":44557,"DIRECTION":"LR","MASTER_ID":44556,"metacyc":"RXN-9003","compounds":"4-hydroxybenzoate + all-trans-hexaprenyl diphosphate => 4-hydroxy-3-all-trans-hexaprenylbenzoate + diphosphate"}
{"X":36461,"RHEA_ID":34636,"DIRECTION":"LR","MASTER_ID":34635,"metacyc":"RXN-12654","compounds":"1-deoxy-11-oxopentalenate + H(+) + NADPH + O2 => H2O + NADP(+) + pentalenolactone D"}
{"X":36462,"RHEA_ID":34637,"compounds":"H2O + NADP(+) + pentalenolactone D => 1-deoxy-11-oxopentalenate + H(+) + NADPH + O2"}
{"X":36463,"RHEA_ID":44560,"DIRECTION":"UN","MASTER_ID":44560,"ec":"2.5.1.39","compounds":"4-hydroxybenzoate + all-trans-heptaprenyl diphosphate = 4-hydroxy-3-all-trans-heptaprenylbenzoate + diphosphate"}
{"X":36464,"RHEA_ID":44561,"DIRECTION":"LR","MASTER_ID":44560,"metacyc":"RXN-9222","compounds":"4-hydroxybenzoate + all-trans-heptaprenyl diphosphate => 4-hydroxy-3-all-trans-heptaprenylbenzoate + diphosphate"}
{"X":36465,"RHEA_ID":34640,"DIRECTION":"LR","MASTER_ID":34639,"metacyc":"RXN-12661","compounds":"1-deoxy-11-oxopentalenate + H(+) + NADPH + O2 => H2O + NADP(+) + neopentalenolactone D"}
{"X":36466,"RHEA_ID":34641,"compounds":"H2O + NADP(+) + neopentalenolactone D => 1-deoxy-11-oxopentalenate + H(+) + NADPH + O2"}
{"X":36467,"RHEA_ID":44564,"DIRECTION":"UN","MASTER_ID":44564,"ec":"2.5.1.39","compounds":"4-hydroxybenzoate + all-trans-decaprenyl diphosphate = 4-hydroxy-3-all-trans-decaprenylbenzoate + diphosphate"}
{"X":36468,"RHEA_ID":44565,"DIRECTION":"LR","MASTER_ID":44564,"metacyc":"RXN-9230","reactome":"R-HSA-2162192.2","compounds":"4-hydroxybenzoate + all-trans-decaprenyl diphosphate => 4-hydroxy-3-all-trans-decaprenylbenzoate + diphosphate"}
{"X":36469,"RHEA_ID":34644,"DIRECTION":"LR","MASTER_ID":34643,"metacyc":"RXN-13752","compounds":"2 S-adenosyl-L-methionine + squalene => 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + 2 H(+) + 2 S-adenosyl-L-homocysteine"}
{"X":36470,"RHEA_ID":34645,"compounds":"3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + 2 H(+) + 2 S-adenosyl-L-homocysteine => 2 S-adenosyl-L-methionine + squalene"}
{"X":36471,"RHEA_ID":44568,"DIRECTION":"UN","MASTER_ID":44568,"ec":"4.1.1.98","compounds":"4-hydroxy-3-all-trans-hexaprenylbenzoate + H(+) = 2-all-trans-hexaprenylphenol + CO2"}
{"X":36472,"RHEA_ID":44569,"compounds":"4-hydroxy-3-all-trans-hexaprenylbenzoate + H(+) => 2-all-trans-hexaprenylphenol + CO2"}
{"X":36473,"RHEA_ID":44570,"compounds":"2-all-trans-hexaprenylphenol + CO2 => 4-hydroxy-3-all-trans-hexaprenylbenzoate + H(+)"}
{"X":36474,"RHEA_ID":34649,"compounds":"3-methyl-1,2-didehydro-2,3-dihydrosqualene + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + squalene"}
{"X":36475,"RHEA_ID":44572,"DIRECTION":"UN","MASTER_ID":44572,"ec":"4.1.1.98","compounds":"4-hydroxy-3-all-trans-heptaprenylbenzoate + H(+) = 2-all-trans-heptaprenylphenol + CO2"}
{"X":36476,"RHEA_ID":44573,"DIRECTION":"LR","MASTER_ID":44572,"metacyc":"RXN-9223","compounds":"4-hydroxy-3-all-trans-heptaprenylbenzoate + H(+) => 2-all-trans-heptaprenylphenol + CO2"}
{"X":36477,"RHEA_ID":44574,"compounds":"2-all-trans-heptaprenylphenol + CO2 => 4-hydroxy-3-all-trans-heptaprenylbenzoate + H(+)"}
{"X":36478,"RHEA_ID":34653,"compounds":"3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + H(+) + S-adenosyl-L-homocysteine => 3-methyl-1,2-didehydro-2,3-dihydrosqualene + S-adenosyl-L-methionine"}
{"X":36479,"RHEA_ID":44576,"DIRECTION":"UN","MASTER_ID":44576,"ec":"4.1.1.98","compounds":"4-hydroxy-3-all-trans-nonaprenylbenzoate + H(+) = 2-all-trans-nonaprenylphenol + CO2"}
{"X":36480,"RHEA_ID":44577,"DIRECTION":"LR","MASTER_ID":44576,"metacyc":"RXN-9238","compounds":"4-hydroxy-3-all-trans-nonaprenylbenzoate + H(+) => 2-all-trans-nonaprenylphenol + CO2"}
{"X":36481,"RHEA_ID":44578,"compounds":"2-all-trans-nonaprenylphenol + CO2 => 4-hydroxy-3-all-trans-nonaprenylbenzoate + H(+)"}
{"X":36482,"RHEA_ID":34657,"compounds":"3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + 2 H(+) + 2 S-adenosyl-L-homocysteine => C30 botryococcene + 2 S-adenosyl-L-methionine"}
{"X":36483,"RHEA_ID":44580,"DIRECTION":"UN","MASTER_ID":44580,"ec":"4.1.1.98","compounds":"4-hydroxy-3-all-trans-decaprenylbenzoate + H(+) = 2-all-trans-decaprenylphenol + CO2"}
{"X":36484,"RHEA_ID":44581,"DIRECTION":"LR","MASTER_ID":44580,"metacyc":"RXN-9231","compounds":"4-hydroxy-3-all-trans-decaprenylbenzoate + H(+) => 2-all-trans-decaprenylphenol + CO2"}
{"X":36485,"RHEA_ID":44582,"compounds":"2-all-trans-decaprenylphenol + CO2 => 4-hydroxy-3-all-trans-decaprenylbenzoate + H(+)"}
{"X":36486,"RHEA_ID":34661,"compounds":"3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine => C30 botryococcene + S-adenosyl-L-methionine"}
{"X":36487,"RHEA_ID":44584,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-(1'-sn-glycerol)"}
{"X":36488,"RHEA_ID":44585,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-(1'-sn-glycerol)"}
{"X":36489,"RHEA_ID":44586,"compounds":"(9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-(1'-sn-glycerol) => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O"}
{"X":36490,"RHEA_ID":34665,"compounds":"3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine => 20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + S-adenosyl-L-methionine"}
{"X":36491,"RHEA_ID":44588,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-1D-myo-inositol"}
{"X":36492,"RHEA_ID":44589,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-1D-myo-inositol"}
{"X":36493,"RHEA_ID":34668,"DIRECTION":"LR","MASTER_ID":34667,"metacyc":"RXN-13282","compounds":"C30 botryococcene + S-adenosyl-L-methionine => 20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine"}
{"X":36494,"RHEA_ID":34669,"compounds":"20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine => C30 botryococcene + S-adenosyl-L-methionine"}
{"X":36495,"RHEA_ID":44592,"DIRECTION":"UN","MASTER_ID":44592,"ec":"2.1.1.222","compounds":"3-(all-trans-heptaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = 2-methoxy-6-(all-trans-heptaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine"}
{"X":36496,"RHEA_ID":44593,"DIRECTION":"LR","MASTER_ID":44592,"metacyc":"RXN-9225","compounds":"3-(all-trans-heptaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine => 2-methoxy-6-(all-trans-heptaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine"}
{"X":36497,"RHEA_ID":44594,"compounds":"2-methoxy-6-(all-trans-heptaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine => 3-(all-trans-heptaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine"}
{"X":36498,"RHEA_ID":34673,"compounds":"3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine => 3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + S-adenosyl-L-methionine"}
{"X":36499,"RHEA_ID":44596,"compounds":"a fatty acyl-[ACP] + H2O = a fatty acid + H(+) + holo-[ACP]"}
{"X":36500,"RHEA_ID":44597,"compounds":"a fatty acyl-[ACP] + H2O => a fatty acid + H(+) + holo-[ACP]"}
{"X":36501,"RHEA_ID":44598,"compounds":"a fatty acid + H(+) + holo-[ACP] => a fatty acyl-[ACP] + H2O"}
{"X":36502,"RHEA_ID":34677,"compounds":"CMP-N,N-diacetyllegionaminate + diphosphate => CTP + N,N-diacetyllegionaminate"}
{"X":36503,"RHEA_ID":44600,"compounds":"a fatty acid + ATP + H(+) = a fatty acyl-AMP + diphosphate"}
{"X":36504,"RHEA_ID":44601,"compounds":"a fatty acid + ATP + H(+) => a fatty acyl-AMP + diphosphate"}
{"X":36505,"RHEA_ID":44602,"compounds":"a fatty acyl-AMP + diphosphate => a fatty acid + ATP + H(+)"}
{"X":36506,"RHEA_ID":34681,"compounds":"adenine + alpha-D-ribose 1-methylphosphonate 5-triphosphate => ATP + methylphosphonate"}
{"X":36507,"RHEA_ID":34682,"compounds":"ATP + methylphosphonate <=> adenine + alpha-D-ribose 1-methylphosphonate 5-triphosphate"}
{"X":36508,"RHEA_ID":34683,"DIRECTION":"UN","MASTER_ID":34683,"ec":"3.6.1.63","compounds":"alpha-D-ribose 1-methylphosphonate 5-triphosphate + H2O = alpha-D-ribose 1-methylphosphonate 5-phosphate + diphosphate + H(+)"}
{"X":36509,"RHEA_ID":34684,"DIRECTION":"LR","MASTER_ID":34683,"metacyc":"RXN0-6733","compounds":"alpha-D-ribose 1-methylphosphonate 5-triphosphate + H2O => alpha-D-ribose 1-methylphosphonate 5-phosphate + diphosphate + H(+)"}
{"X":36510,"RHEA_ID":34685,"compounds":"alpha-D-ribose 1-methylphosphonate 5-phosphate + diphosphate + H(+) => alpha-D-ribose 1-methylphosphonate 5-triphosphate + H2O"}
{"X":36511,"RHEA_ID":34686,"compounds":"alpha-D-ribose 1-methylphosphonate 5-triphosphate + H2O <=> alpha-D-ribose 1-methylphosphonate 5-phosphate + diphosphate + H(+)"}
{"X":36512,"RHEA_ID":34687,"compounds":"AH2 + N-acyl-15-methylhexadecasphinganine + O2 = A + 2 H2O + N-acyl-15-methylhexadecasphing-4-enine"}
{"X":36513,"RHEA_ID":44610,"compounds":"2-methoxy-6-(all-trans-nonaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine => 3-(all-trans-nonaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine"}
{"X":36514,"RHEA_ID":34689,"compounds":"A + 2 H2O + N-acyl-15-methylhexadecasphing-4-enine => AH2 + N-acyl-15-methylhexadecasphinganine + O2"}
{"X":36515,"RHEA_ID":34690,"compounds":"AH2 + N-acyl-15-methylhexadecasphinganine + O2 <=> A + 2 H2O + N-acyl-15-methylhexadecasphing-4-enine"}
{"X":36516,"RHEA_ID":44613,"DIRECTION":"LR","MASTER_ID":44612,"metacyc":"RXN-9233","compounds":"3-(all-trans-decaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine => 2-methoxy-6-(all-trans-decaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine"}
{"X":36517,"RHEA_ID":44614,"compounds":"2-methoxy-6-(all-trans-decaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine => 3-(all-trans-decaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine"}
{"X":36518,"RHEA_ID":34693,"compounds":"acryloyl-CoA + H2O => (R)-lactoyl-CoA"}
{"X":36519,"RHEA_ID":34694,"DIRECTION":"BI","MASTER_ID":34691,"metacyc":"LACTOYL-COA-DEHYDRATASE-RXN","compounds":"(R)-lactoyl-CoA <=> acryloyl-CoA + H2O"}
{"X":36520,"RHEA_ID":44617,"compounds":"1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + H2O => 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+)"}
{"X":36521,"RHEA_ID":34696,"DIRECTION":"LR","MASTER_ID":34695,"metacyc":"RXN-13761","compounds":"(2E,6E)-farnesyl diphosphate => Delta(6)-protoilludene + diphosphate"}
{"X":36522,"RHEA_ID":34697,"compounds":"Delta(6)-protoilludene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":36523,"RHEA_ID":44620,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphinganine = a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphocholine"}
{"X":36524,"RHEA_ID":34699,"DIRECTION":"UN","MASTER_ID":34699,"ec":"4.2.3.136","compounds":"(2E,6E)-farnesyl diphosphate = (-)-alpha-isocomene + diphosphate"}
{"X":36525,"RHEA_ID":34700,"DIRECTION":"LR","MASTER_ID":34699,"metacyc":"RXN-13762","compounds":"(2E,6E)-farnesyl diphosphate => (-)-alpha-isocomene + diphosphate"}
{"X":36526,"RHEA_ID":34701,"compounds":"(-)-alpha-isocomene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":36527,"RHEA_ID":44624,"DIRECTION":"UN","MASTER_ID":44624,"ec":"1.1.1.384","compounds":"dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + NADP(+) = dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H(+) + NADPH"}
{"X":36528,"RHEA_ID":44625,"compounds":"dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + NADP(+) => dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H(+) + NADPH"}
{"X":36529,"RHEA_ID":44626,"DIRECTION":"RL","MASTER_ID":44624,"metacyc":"RXN-16262","compounds":"dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H(+) + NADPH => dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + NADP(+)"}
{"X":36530,"RHEA_ID":34705,"compounds":"(E)-2-epi-beta-caryophyllene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":36531,"RHEA_ID":44628,"DIRECTION":"UN","MASTER_ID":44628,"ec":"1.1.1.385","compounds":"L-dihydroanticapsin + NAD(+) = H(+) + L-anticapsin + NADH"}
{"X":36532,"RHEA_ID":34707,"DIRECTION":"UN","MASTER_ID":34707,"ec":"4.7.1.1","compounds":"AH2 + alpha-D-ribose 1-methylphosphonate 5-phosphate + S-adenosyl-L-methionine = 5'-deoxyadenosine + A + alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H(+) + L-methionine + methane"}
{"X":36533,"RHEA_ID":44630,"compounds":"H(+) + L-anticapsin + NADH => L-dihydroanticapsin + NAD(+)"}
{"X":36534,"RHEA_ID":34709,"compounds":"5'-deoxyadenosine + A + alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H(+) + L-methionine + methane => AH2 + alpha-D-ribose 1-methylphosphonate 5-phosphate + S-adenosyl-L-methionine"}
{"X":36535,"RHEA_ID":44632,"DIRECTION":"UN","MASTER_ID":44632,"ec":"1.13.11.80","compounds":"(3,5-dihydroxyphenyl)acetyl-CoA + O2 = 2-(3,5-dihydroxyphenyl)-2-oxoacetate + CoA + H(+)"}
{"X":36536,"RHEA_ID":34711,"compounds":"H2O + N-acyl-15-methylhexadecasphing-4-enine = 15-methylhexadecasphing-4-enine + a fatty acid"}
{"X":36537,"RHEA_ID":54618,"compounds":"2-hydroxyheptadecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + heptadecanoyl-CoA + O2"}
{"X":36538,"RHEA_ID":34713,"compounds":"15-methylhexadecasphing-4-enine + a fatty acid => H2O + N-acyl-15-methylhexadecasphing-4-enine"}
{"X":36539,"RHEA_ID":34714,"compounds":"H2O + N-acyl-15-methylhexadecasphing-4-enine <=> 15-methylhexadecasphing-4-enine + a fatty acid"}
{"X":36540,"RHEA_ID":34715,"compounds":"15-methylhexadecasphing-4-enine + ATP = 15-methylhexadecasphing-4-enine 1-phosphate + ADP + H(+)"}
{"X":36541,"RHEA_ID":44638,"compounds":"2,4-dinitrophenol + H(+) + methanol => 2,4-dinitroanisole + H2O"}
{"X":36542,"RHEA_ID":34717,"compounds":"15-methylhexadecasphing-4-enine 1-phosphate + ADP + H(+) => 15-methylhexadecasphing-4-enine + ATP"}
{"X":36543,"RHEA_ID":34718,"compounds":"15-methylhexadecasphing-4-enine + ATP <=> 15-methylhexadecasphing-4-enine 1-phosphate + ADP + H(+)"}
{"X":36544,"RHEA_ID":34719,"compounds":"15-methylhexadecasphing-4-enine 1-phosphate = (2E)-13-methyltetradecenal + phosphoethanolamine"}
{"X":36545,"RHEA_ID":54626,"compounds":"2-hydroxyoctadecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + O2 + octadecanoyl-CoA"}
{"X":36546,"RHEA_ID":34721,"compounds":"(2E)-13-methyltetradecenal + phosphoethanolamine => 15-methylhexadecasphing-4-enine 1-phosphate"}
{"X":36547,"RHEA_ID":34722,"compounds":"15-methylhexadecasphing-4-enine 1-phosphate <=> (2E)-13-methyltetradecenal + phosphoethanolamine"}
{"X":36548,"RHEA_ID":34723,"compounds":"15-methylhexadecasphing-4-enine 1-phosphate + H2O = 15-methylhexadecasphing-4-enine + phosphate"}
{"X":36549,"RHEA_ID":54630,"compounds":"2-hydroxydodecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + dodecanoyl-CoA + O2"}
{"X":36550,"RHEA_ID":34725,"compounds":"15-methylhexadecasphing-4-enine + phosphate => 15-methylhexadecasphing-4-enine 1-phosphate + H2O"}
{"X":36551,"RHEA_ID":34726,"compounds":"15-methylhexadecasphing-4-enine 1-phosphate + H2O <=> 15-methylhexadecasphing-4-enine + phosphate"}
{"X":36552,"RHEA_ID":34727,"compounds":"H2O + N-acyl-15-methylhexadecasphinganine = 15-methylhexadecasphinganine + a carboxylate"}
{"X":36553,"RHEA_ID":44650,"compounds":"a 2-acyl-sn-glycerol 3-phosphate + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphate + H2O"}
{"X":36554,"RHEA_ID":34729,"compounds":"15-methylhexadecasphinganine + a carboxylate => H2O + N-acyl-15-methylhexadecasphinganine"}
{"X":36555,"RHEA_ID":34730,"compounds":"H2O + N-acyl-15-methylhexadecasphinganine <=> 15-methylhexadecasphinganine + a carboxylate"}
{"X":36556,"RHEA_ID":34731,"compounds":"15-methylhexadecasphing-4-enine + an acyl-CoA = CoA + H(+) + N-acyl-15-methylhexadecasphing-4-enine"}
{"X":36557,"RHEA_ID":44654,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine => a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a 1-acyl-sn-glycero-3-phosphocholine"}
{"X":36558,"RHEA_ID":34733,"compounds":"CoA + H(+) + N-acyl-15-methylhexadecasphing-4-enine => 15-methylhexadecasphing-4-enine + an acyl-CoA"}
{"X":36559,"RHEA_ID":34734,"compounds":"15-methylhexadecasphing-4-enine + an acyl-CoA <=> CoA + H(+) + N-acyl-15-methylhexadecasphing-4-enine"}
{"X":36560,"RHEA_ID":34735,"compounds":"an acyl-CoA + sphinganine = an N-acylsphinganine + CoA + H(+)"}
{"X":36561,"RHEA_ID":44658,"compounds":"a monoacyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine"}
{"X":36562,"RHEA_ID":34737,"compounds":"an N-acylsphinganine + CoA + H(+) => an acyl-CoA + sphinganine"}
{"X":36563,"RHEA_ID":34738,"compounds":"an acyl-CoA + sphinganine <=> an N-acylsphinganine + CoA + H(+)"}
{"X":36564,"RHEA_ID":34739,"DIRECTION":"UN","MASTER_ID":34739,"ec":"3.1.4.12","compounds":"H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine = H(+) + N-acyl-15-methylhexadecasphing-4-enine + phosphocholine"}
{"X":36565,"RHEA_ID":44662,"compounds":"1-O-alkyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine + H(+) => 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + sphing-4-enine"}
{"X":36566,"RHEA_ID":34741,"compounds":"H(+) + N-acyl-15-methylhexadecasphing-4-enine + phosphocholine => H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine"}
{"X":36567,"RHEA_ID":34743,"compounds":"15-methylhexadecasphinganine 1-phosphate = 13-methyltetradecanal + phosphoethanolamine"}
{"X":36568,"RHEA_ID":44666,"compounds":"a fatty acid + a monoacyl-sn-glycero-3-phosphocholine + H(+) => a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O"}
{"X":36569,"RHEA_ID":34745,"compounds":"13-methyltetradecanal + phosphoethanolamine => 15-methylhexadecasphinganine 1-phosphate"}
{"X":36570,"RHEA_ID":34746,"compounds":"15-methylhexadecasphinganine 1-phosphate <=> 13-methyltetradecanal + phosphoethanolamine"}
{"X":36571,"RHEA_ID":34747,"compounds":"15-methylhexadecasphinganine + ATP = 15-methylhexadecasphinganine 1-phosphate + ADP + H(+)"}
{"X":36572,"RHEA_ID":54654,"DIRECTION":"RL","MASTER_ID":54652,"metacyc":"RXN-18975","compounds":"all-trans-geranylgeranyl diphosphate + H2O => peregrinol diphosphate"}
{"X":36573,"RHEA_ID":34749,"compounds":"15-methylhexadecasphinganine 1-phosphate + ADP + H(+) => 15-methylhexadecasphinganine + ATP"}
{"X":36574,"RHEA_ID":34750,"compounds":"15-methylhexadecasphinganine + ATP <=> 15-methylhexadecasphinganine 1-phosphate + ADP + H(+)"}
{"X":36575,"RHEA_ID":34751,"compounds":"ATP + N-acyl-15-methylhexadecasphing-4-enine = ADP + H(+) + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate"}
{"X":36576,"RHEA_ID":54658,"compounds":"geraniol => linalool"}
{"X":36577,"RHEA_ID":34753,"compounds":"ADP + H(+) + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate => ATP + N-acyl-15-methylhexadecasphing-4-enine"}
{"X":36578,"RHEA_ID":34754,"compounds":"ATP + N-acyl-15-methylhexadecasphing-4-enine <=> ADP + H(+) + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate"}
{"X":36579,"RHEA_ID":34755,"compounds":"H2O + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine = D-glucose + N-acyl-15-methylhexadecasphing-4-enine"}
{"X":36580,"RHEA_ID":44678,"compounds":"a diacylglycerol + an all-trans-retinyl ester => a triacyl-sn-glycerol + all-trans-retinol"}
{"X":36581,"RHEA_ID":34757,"compounds":"D-glucose + N-acyl-15-methylhexadecasphing-4-enine => H2O + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine"}
{"X":36582,"RHEA_ID":44680,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ADP + H(+)"}
{"X":36583,"RHEA_ID":34759,"compounds":"ATP + glycerol 2-phosphate(out) + H2O = ADP + glycerol 2-phosphate(in) + H(+) + phosphate"}
{"X":36584,"RHEA_ID":44682,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP"}
{"X":36585,"RHEA_ID":34761,"compounds":"ADP + glycerol 2-phosphate(in) + H(+) + phosphate => ATP + glycerol 2-phosphate(out) + H2O"}
{"X":36586,"RHEA_ID":34762,"compounds":"ATP + glycerol 2-phosphate(out) + H2O <=> ADP + glycerol 2-phosphate(in) + H(+) + phosphate"}
{"X":36587,"RHEA_ID":34763,"compounds":"(S,S)-tartrate(out) + succinate(in) = (S,S)-tartrate(in) + succinate(out)"}
{"X":36588,"RHEA_ID":44686,"compounds":"1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine"}
{"X":36589,"RHEA_ID":34765,"compounds":"(S,S)-tartrate(in) + succinate(out) => (S,S)-tartrate(out) + succinate(in)"}
{"X":36590,"RHEA_ID":44688,"compounds":"a 2-acylglycerol + H2O = a fatty acid + glycerol + H(+)"}
{"X":36591,"RHEA_ID":34767,"compounds":"5,10-methenyltetrahydrofolate + H2O = 5-formyltetrahydrofolate + H(+)"}
{"X":36592,"RHEA_ID":34768,"DIRECTION":"LR","MASTER_ID":34767,"ecocyc":"RXN-6321","metacyc":"RXN-6321","compounds":"5,10-methenyltetrahydrofolate + H2O => 5-formyltetrahydrofolate + H(+)"}
{"X":36593,"RHEA_ID":34769,"compounds":"5-formyltetrahydrofolate + H(+) => 5,10-methenyltetrahydrofolate + H2O"}
{"X":36594,"RHEA_ID":44692,"compounds":"an acyl-CoA + hexadecasphinganine = CoA + H(+) + N-acylhexadecasphinganine"}
{"X":36595,"RHEA_ID":34771,"DIRECTION":"UN","MASTER_ID":34771,"ec":"1.1.1.170","compounds":"a 3beta-hydroxysteroid-4alpha-carboxylate + NADP(+) = a 3-oxosteroid + CO2 + NADPH"}
{"X":36596,"RHEA_ID":44694,"compounds":"CoA + H(+) + N-acylhexadecasphinganine => an acyl-CoA + hexadecasphinganine"}
{"X":36597,"RHEA_ID":34773,"compounds":"a 3-oxosteroid + CO2 + NADPH => a 3beta-hydroxysteroid-4alpha-carboxylate + NADP(+)"}
{"X":36598,"RHEA_ID":54684,"DIRECTION":"UN","MASTER_ID":54684,"ec":"5.5.1.28","compounds":"all-trans-geranylgeranyl diphosphate = (-)-kolavenyl diphosphate"}
{"X":36599,"RHEA_ID":34775,"DIRECTION":"UN","MASTER_ID":34775,"ec":"1.1.1.170","compounds":"a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(+) = a 3-oxosteroid + CO2 + NADH"}
{"X":36600,"RHEA_ID":44698,"compounds":"a fatty acid + H(+) + sn-glycerol 3-phosphocholine => a 2-acyl-sn-glycero-3-phosphocholine + H2O"}
{"X":36601,"RHEA_ID":34776,"DIRECTION":"LR","MASTER_ID":34775,"metacyc":"RXN-13926","compounds":"a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(+) => a 3-oxosteroid + CO2 + NADH"}
{"X":36602,"RHEA_ID":44700,"compounds":"a 2,3-saturated acyl-CoA + FAD + H(+) = a (2E)-enoyl-CoA + FADH2"}
{"X":36603,"RHEA_ID":34777,"compounds":"a 3-oxosteroid + CO2 + NADH => a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(+)"}
{"X":36604,"RHEA_ID":44702,"compounds":"a (2E)-enoyl-CoA + FADH2 => a 2,3-saturated acyl-CoA + FAD + H(+)"}
{"X":36605,"RHEA_ID":34779,"DIRECTION":"UN","MASTER_ID":34779,"ec":"1.1.1.357","compounds":"a 3alpha-hydroxysteroid + NAD(+) = a 3-oxosteroid + H(+) + NADH"}
{"X":36606,"RHEA_ID":44704,"compounds":"a 2,3-saturated acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":36607,"RHEA_ID":34779,"DIRECTION":"UN","MASTER_ID":34779,"ec":"1.1.1.50","compounds":"a 3alpha-hydroxysteroid + NAD(+) = a 3-oxosteroid + H(+) + NADH"}
{"X":36608,"RHEA_ID":44706,"compounds":"a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein] => a 2,3-saturated acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":36609,"RHEA_ID":34781,"compounds":"a 3-oxosteroid + H(+) + NADH => a 3alpha-hydroxysteroid + NAD(+)"}
{"X":36610,"RHEA_ID":54696,"DIRECTION":"UN","MASTER_ID":54696,"ec":"6.2.1.50","compounds":"4-hydroxybenzoate + ATP + holo-[4-hydroxyphenylalkanoate synthase] = 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + diphosphate"}
{"X":36611,"RHEA_ID":34783,"DIRECTION":"UN","MASTER_ID":34783,"ec":"1.1.1.357","compounds":"a 3alpha-hydroxysteroid + NADP(+) = a 3-oxosteroid + H(+) + NADPH"}
{"X":36612,"RHEA_ID":44710,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine => a 1-acyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine"}
{"X":36613,"RHEA_ID":34783,"DIRECTION":"UN","MASTER_ID":34783,"ec":"1.1.1.213","compounds":"a 3alpha-hydroxysteroid + NADP(+) = a 3-oxosteroid + H(+) + NADPH"}
{"X":36614,"RHEA_ID":44712,"compounds":"a 1,2-diacylglycerol + H2O = a 1-acylglycerol + a fatty acid + H(+)"}
{"X":36615,"RHEA_ID":34785,"compounds":"a 3-oxosteroid + H(+) + NADPH => a 3alpha-hydroxysteroid + NADP(+)"}
{"X":36616,"RHEA_ID":54702,"compounds":"4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + H(+) => 4-hydroxybenzoyl-5'-AMP + holo-[4-hydroxyphenylalkanoate synthase]"}
{"X":36617,"RHEA_ID":34787,"DIRECTION":"UN","MASTER_ID":34787,"ec":"1.1.1.270","compounds":"a 3beta-hydroxysteroid + NADP(+) = a 3-oxosteroid + H(+) + NADPH"}
{"X":36618,"RHEA_ID":34788,"compounds":"a 3beta-hydroxysteroid + NADP(+) => a 3-oxosteroid + H(+) + NADPH"}
{"X":36619,"RHEA_ID":34789,"compounds":"a 3-oxosteroid + H(+) + NADPH => a 3beta-hydroxysteroid + NADP(+)"}
{"X":36620,"RHEA_ID":44718,"compounds":"AH2 + all-trans-4,4'-diapolycopen-4-oate + H(+) => A + all-trans-4,4'-diapolycopen-4-al + H2O"}
{"X":36621,"RHEA_ID":34791,"DIRECTION":"UN","MASTER_ID":34791,"ec":"1.13.11.72","compounds":"2-hydroxyethylphosphonate + O2 = formate + H(+) + hydroxymethylphosphonate"}
{"X":36622,"RHEA_ID":44720,"compounds":"a 1-acyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycerol + H(+) + phosphocholine"}
{"X":36623,"RHEA_ID":34793,"compounds":"formate + H(+) + hydroxymethylphosphonate => 2-hydroxyethylphosphonate + O2"}
{"X":36624,"RHEA_ID":54710,"compounds":"H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine"}
{"X":36625,"RHEA_ID":34795,"DIRECTION":"UN","MASTER_ID":34795,"ec":"3.1.4.55","compounds":"alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O = alpha-D-ribose 1,5-bisphosphate + H(+)"}
{"X":36626,"RHEA_ID":44724,"compounds":"2,3-saturated fatty aldehyde + NADP(+) = (2E)-fatty aldehyde + H(+) + NADPH"}
{"X":36627,"RHEA_ID":34797,"compounds":"alpha-D-ribose 1,5-bisphosphate + H(+) => alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O"}
{"X":36628,"RHEA_ID":34798,"compounds":"alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O <=> alpha-D-ribose 1,5-bisphosphate + H(+)"}
{"X":36629,"RHEA_ID":34799,"compounds":"2,3-didehydroadipoyl-CoA + acetyl-CoA = 3-oxo-5,6-didehydrosuberyl-CoA + CoA"}
{"X":36630,"RHEA_ID":44728,"compounds":"1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+)"}
{"X":36631,"RHEA_ID":34801,"compounds":"3-oxo-5,6-didehydrosuberyl-CoA + CoA => 2,3-didehydroadipoyl-CoA + acetyl-CoA"}
{"X":36632,"RHEA_ID":34802,"compounds":"2,3-didehydroadipoyl-CoA + acetyl-CoA <=> 3-oxo-5,6-didehydrosuberyl-CoA + CoA"}
{"X":36633,"RHEA_ID":34803,"DIRECTION":"UN","MASTER_ID":34803,"ec":"2.3.1.211","compounds":"2 4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA = bisdemethoxycurcumin + 2 CO2 + 3 CoA"}
{"X":36634,"RHEA_ID":44732,"compounds":"2-(9Z,12Z-octadecadienoyl)-glycerol + H2O = (9Z,12Z)-octadecadienoate + glycerol + H(+)"}
{"X":36635,"RHEA_ID":34805,"compounds":"bisdemethoxycurcumin + 2 CO2 + 3 CoA => 2 4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA"}
{"X":36636,"RHEA_ID":54722,"compounds":"H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine"}
{"X":36637,"RHEA_ID":34807,"compounds":"(R)-dihydrocamalexate + O2 + reduced [NADPH--hemoprotein reductase] = camalexin + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":36638,"RHEA_ID":44736,"DIRECTION":"UN","MASTER_ID":44736,"ec":"2.3.1.245","compounds":"acetyl-CoA + dihydroxyacetone phosphate = 3-hydroxy-2,4-pentanedione 5-phosphate + CoA"}
{"X":36639,"RHEA_ID":34809,"compounds":"camalexin + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (R)-dihydrocamalexate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":36640,"RHEA_ID":54726,"compounds":"3 H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine => N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine"}
{"X":36641,"RHEA_ID":34811,"DIRECTION":"UN","MASTER_ID":34811,"ec":"1.3.1.n3","compounds":"NADP(+) + tetrahydrocurcumin = dihydrocurcumin + H(+) + NADPH"}
{"X":36642,"RHEA_ID":44740,"DIRECTION":"UN","MASTER_ID":44740,"ec":"2.1.1.315","compounds":"27-O-demethylrifamycin SV + S-adenosyl-L-methionine = H(+) + rifamycin SV + S-adenosyl-L-homocysteine"}
{"X":36643,"RHEA_ID":34813,"compounds":"dihydrocurcumin + H(+) + NADPH => NADP(+) + tetrahydrocurcumin"}
{"X":36644,"RHEA_ID":34814,"compounds":"NADP(+) + tetrahydrocurcumin <=> dihydrocurcumin + H(+) + NADPH"}
{"X":36645,"RHEA_ID":34815,"DIRECTION":"UN","MASTER_ID":34815,"ec":"1.3.1.n3","compounds":"2 NADP(+) + tetrahydrocurcumin = curcumin + 2 H(+) + 2 NADPH"}
{"X":36646,"RHEA_ID":34816,"compounds":"2 NADP(+) + tetrahydrocurcumin => curcumin + 2 H(+) + 2 NADPH"}
{"X":36647,"RHEA_ID":34817,"compounds":"curcumin + 2 H(+) + 2 NADPH => 2 NADP(+) + tetrahydrocurcumin"}
{"X":36648,"RHEA_ID":44746,"compounds":"(3,5-dihydroxyphenyl)acetyl-CoA + 4 CO2 + 3 CoA + H2O => 4 H(+) + 4 malonyl-CoA"}
{"X":36649,"RHEA_ID":34819,"DIRECTION":"UN","MASTER_ID":34819,"ec":"1.3.1.n3","compounds":"dihydrocurcumin + NADP(+) = curcumin + H(+) + NADPH"}
{"X":36650,"RHEA_ID":44748,"DIRECTION":"UN","MASTER_ID":44748,"ec":"2.7.1.223","compounds":"5-amino-1-(beta-D-ribosyl)imidazole + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+)"}
{"X":36651,"RHEA_ID":34821,"DIRECTION":"RL","MASTER_ID":34819,"metacyc":"RXN0-6676","compounds":"curcumin + H(+) + NADPH => dihydrocurcumin + NADP(+)"}
{"X":36652,"RHEA_ID":44750,"compounds":"5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) => 5-amino-1-(beta-D-ribosyl)imidazole + ATP"}
{"X":36653,"RHEA_ID":34823,"DIRECTION":"UN","MASTER_ID":34823,"ec":"2.3.1.217","compounds":"(E)-feruloyl-CoA + (E)-feruloylacetyl-CoA + H2O = CO2 + 2 CoA + curcumin"}
{"X":36654,"RHEA_ID":34824,"DIRECTION":"LR","MASTER_ID":34823,"metacyc":"RXN-11226","compounds":"(E)-feruloyl-CoA + (E)-feruloylacetyl-CoA + H2O => CO2 + 2 CoA + curcumin"}
{"X":36655,"RHEA_ID":34825,"compounds":"CO2 + 2 CoA + curcumin => (E)-feruloyl-CoA + (E)-feruloylacetyl-CoA + H2O"}
{"X":36656,"RHEA_ID":54742,"compounds":"19-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":36657,"RHEA_ID":34827,"compounds":"H(+) + N-acyl-15-methylhexadecasphinganine + NADPH + O2 = H2O + N-acyl-4-hydroxy-15-methylhexadecasphinganine + NADP(+)"}
{"X":36658,"RHEA_ID":44756,"DIRECTION":"UN","MASTER_ID":44756,"ec":"2.1.1.201","compounds":"2-methoxy-6-all-trans-heptaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = 6-methoxy-3-methyl-2-all-trans-heptaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine"}
{"X":36659,"RHEA_ID":34829,"compounds":"H2O + N-acyl-4-hydroxy-15-methylhexadecasphinganine + NADP(+) => H(+) + N-acyl-15-methylhexadecasphinganine + NADPH + O2"}
{"X":36660,"RHEA_ID":34830,"compounds":"H(+) + N-acyl-15-methylhexadecasphinganine + NADPH + O2 <=> H2O + N-acyl-4-hydroxy-15-methylhexadecasphinganine + NADP(+)"}
{"X":36661,"RHEA_ID":34831,"compounds":"H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate = N-acyl-15-methylhexadecasphing-4-enine + phosphate"}
{"X":36662,"RHEA_ID":44760,"DIRECTION":"UN","MASTER_ID":44760,"ec":"2.1.1.201","compounds":"2-methoxy-6-all-trans-nonaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = 6-methoxy-3-methyl-2-all-trans-nonaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine"}
{"X":36663,"RHEA_ID":34833,"compounds":"N-acyl-15-methylhexadecasphing-4-enine + phosphate => H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate"}
{"X":36664,"RHEA_ID":34834,"compounds":"H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate <=> N-acyl-15-methylhexadecasphing-4-enine + phosphate"}
{"X":36665,"RHEA_ID":34835,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-4-hydroxy-15-methylhexadecasphinganine = a 1,2-diacyl-sn-glycerol + N-acyl-4-hydroxy-15-methylhexadecasphinganine-1-phosphocholine"}
{"X":36666,"RHEA_ID":44764,"DIRECTION":"UN","MASTER_ID":44764,"ec":"2.1.1.201","compounds":"2-methoxy-6-all-trans-decaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = 6-methoxy-3-methyl-2-all-trans-decaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine"}
{"X":36667,"RHEA_ID":34837,"compounds":"a 1,2-diacyl-sn-glycerol + N-acyl-4-hydroxy-15-methylhexadecasphinganine-1-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-4-hydroxy-15-methylhexadecasphinganine"}
{"X":36668,"RHEA_ID":34838,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-4-hydroxy-15-methylhexadecasphinganine <=> a 1,2-diacyl-sn-glycerol + N-acyl-4-hydroxy-15-methylhexadecasphinganine-1-phosphocholine"}
{"X":36669,"RHEA_ID":34839,"DIRECTION":"UN","MASTER_ID":34839,"ec":"2.3.1.216","compounds":"4 H(+) + 5 malonyl-CoA = 5,7-dihydroxy-2-methyl-4H-chromen-4-one + 5 CO2 + 5 CoA + H2O"}
{"X":36670,"RHEA_ID":44768,"compounds":"3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) = 2-methoxy-6-(all-trans-hexaprenyl)phenol + CO2"}
{"X":36671,"RHEA_ID":34841,"compounds":"5,7-dihydroxy-2-methyl-4H-chromen-4-one + 5 CO2 + 5 CoA + H2O => 4 H(+) + 5 malonyl-CoA"}
{"X":36672,"RHEA_ID":44770,"compounds":"2-methoxy-6-(all-trans-hexaprenyl)phenol + CO2 => 3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+)"}
{"X":36673,"RHEA_ID":34843,"compounds":"7,8-dihydromonapterin 3'-triphosphate + 3 H2O = 7,8-dihydromonapterin + 2 H(+) + 3 phosphate"}
{"X":36674,"RHEA_ID":44772,"compounds":"2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + NADPH + O2 = 2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + H2O + NADP(+)"}
{"X":36675,"RHEA_ID":34845,"compounds":"7,8-dihydromonapterin + 2 H(+) + 3 phosphate => 7,8-dihydromonapterin 3'-triphosphate + 3 H2O"}
{"X":36676,"RHEA_ID":34846,"compounds":"7,8-dihydromonapterin 3'-triphosphate + 3 H2O <=> 7,8-dihydromonapterin + 2 H(+) + 3 phosphate"}
{"X":36677,"RHEA_ID":34847,"DIRECTION":"UN","MASTER_ID":34847,"ec":"1.5.1.50","compounds":"7,8-dihydromonapterin + H(+) + NADPH = 5,6,7,8-tetrahydromonapterin + NADP(+)"}
{"X":36678,"RHEA_ID":44776,"DIRECTION":"UN","MASTER_ID":44776,"ec":"2.1.1.163","compounds":"2-demethylmenaquinol-6 + S-adenosyl-L-methionine = H(+) + menaquinol-6 + S-adenosyl-L-homocysteine"}
{"X":36679,"RHEA_ID":34849,"compounds":"5,6,7,8-tetrahydromonapterin + NADP(+) => 7,8-dihydromonapterin + H(+) + NADPH"}
{"X":36680,"RHEA_ID":34850,"compounds":"7,8-dihydromonapterin + H(+) + NADPH <=> 5,6,7,8-tetrahydromonapterin + NADP(+)"}
{"X":36681,"RHEA_ID":34851,"compounds":"(3S)-3-hydroxyadipyl-CoA + NAD(+) = 3-oxoadipyl-CoA + H(+) + NADH"}
{"X":36682,"RHEA_ID":54768,"compounds":"[LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine = [LarE protein]-dehydroalanine + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide"}
{"X":36683,"RHEA_ID":34853,"compounds":"3-oxoadipyl-CoA + H(+) + NADH => (3S)-3-hydroxyadipyl-CoA + NAD(+)"}
{"X":36684,"RHEA_ID":44782,"compounds":"H(+) + menaquinol-9 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-9 + S-adenosyl-L-methionine"}
{"X":36685,"RHEA_ID":34855,"compounds":"2 H2O + iminodiacetonitrile = N-(cyanomethyl)glycine + NH4(+)"}
{"X":36686,"RHEA_ID":54772,"compounds":"ATP + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide = 1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + diphosphate"}
{"X":36687,"RHEA_ID":34857,"compounds":"N-(cyanomethyl)glycine + NH4(+) => 2 H2O + iminodiacetonitrile"}
{"X":36688,"RHEA_ID":34858,"compounds":"2 H2O + iminodiacetonitrile <=> N-(cyanomethyl)glycine + NH4(+)"}
{"X":36689,"RHEA_ID":34859,"compounds":"3-oxocyclopentanecarbonitrile + 2 H2O = 3-oxocyclopentanecarboxylate + NH4(+)"}
{"X":36690,"RHEA_ID":44788,"DIRECTION":"UN","MASTER_ID":44788,"ec":"2.1.1.163","compounds":"2-demethylmenaquinol-11 + S-adenosyl-L-methionine = H(+) + menaquinol-11 + S-adenosyl-L-homocysteine"}
{"X":36691,"RHEA_ID":34861,"compounds":"3-oxocyclopentanecarboxylate + NH4(+) => 3-oxocyclopentanecarbonitrile + 2 H2O"}
{"X":36692,"RHEA_ID":34862,"compounds":"3-oxocyclopentanecarbonitrile + 2 H2O <=> 3-oxocyclopentanecarboxylate + NH4(+)"}
{"X":36693,"RHEA_ID":44791,"compounds":"2-demethylmenaquinol-11 + S-adenosyl-L-methionine <=> H(+) + menaquinol-11 + S-adenosyl-L-homocysteine"}
{"X":36694,"RHEA_ID":44792,"DIRECTION":"UN","MASTER_ID":44792,"ec":"2.1.1.163","compounds":"2-demethylmenaquinol-12 + S-adenosyl-L-methionine = H(+) + menaquinol-12 + S-adenosyl-L-homocysteine"}
{"X":36695,"RHEA_ID":34865,"compounds":"3-hydroxyadipyl-CoA => 2,3-didehydroadipyl-CoA + H2O"}
{"X":36696,"RHEA_ID":34866,"DIRECTION":"BI","MASTER_ID":34863,"ecocyc":"RXN0-6513","metacyc":"RXN0-6513","compounds":"2,3-didehydroadipyl-CoA + H2O <=> 3-hydroxyadipyl-CoA"}
{"X":36697,"RHEA_ID":34867,"compounds":"ATP + CoA + thiophene-2-carboxylate = AMP + diphosphate + thiophene-2-carbonyl-CoA"}
{"X":36698,"RHEA_ID":44796,"DIRECTION":"UN","MASTER_ID":44796,"ec":"2.1.1.163","compounds":"2-demethylmenaquinol-13 + S-adenosyl-L-methionine = H(+) + menaquinol-13 + S-adenosyl-L-homocysteine"}
{"X":36699,"RHEA_ID":34869,"compounds":"AMP + diphosphate + thiophene-2-carbonyl-CoA => ATP + CoA + thiophene-2-carboxylate"}
{"X":36700,"RHEA_ID":34870,"compounds":"ATP + CoA + thiophene-2-carboxylate <=> AMP + diphosphate + thiophene-2-carbonyl-CoA"}
{"X":36701,"RHEA_ID":44799,"compounds":"2-demethylmenaquinol-13 + S-adenosyl-L-methionine <=> H(+) + menaquinol-13 + S-adenosyl-L-homocysteine"}
{"X":36702,"RHEA_ID":34872,"compounds":"methanol(out) => methanol(in)"}
{"X":36703,"RHEA_ID":34873,"DIRECTION":"RL","MASTER_ID":34871,"ecocyc":"TRANS-RXN0-459","compounds":"methanol(in) => methanol(out)"}
{"X":36704,"RHEA_ID":34874,"compounds":"methanol(out) <=> methanol(in)"}
{"X":36705,"RHEA_ID":44803,"compounds":"1,4-dihydroxy-2-naphthoate + all-trans-hexaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-6 + CO2 + diphosphate"}
{"X":36706,"RHEA_ID":44804,"DIRECTION":"UN","MASTER_ID":44804,"ec":"2.5.1.74","compounds":"1,4-dihydroxy-2-naphthoate + all-trans-nonaprenyl diphosphate + H(+) = 2-demethylmenaquinol-9 + CO2 + diphosphate"}
{"X":36707,"RHEA_ID":34877,"compounds":"3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH => 2-oxepin-2(3H)-ylideneacetyl-CoA + 2 H2O + NADP(+)"}
{"X":36708,"RHEA_ID":34878,"compounds":"2-oxepin-2(3H)-ylideneacetyl-CoA + 2 H2O + NADP(+) <=> 3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH"}
{"X":36709,"RHEA_ID":44807,"compounds":"1,4-dihydroxy-2-naphthoate + all-trans-nonaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-9 + CO2 + diphosphate"}
{"X":36710,"RHEA_ID":44808,"DIRECTION":"UN","MASTER_ID":44808,"ec":"2.5.1.74","compounds":"1,4-dihydroxy-2-naphthoate + all-trans-decaprenyl diphosphate + H(+) = 2-demethylmenaquinol-10 + CO2 + diphosphate"}
{"X":36711,"RHEA_ID":34881,"compounds":"4-methoxy-4-oxo-3-phenylbutanoate + NH4(+) => 2 H2O + methyl 3-cyano-2-phenylpropanoate"}
{"X":36712,"RHEA_ID":34882,"compounds":"2 H2O + methyl 3-cyano-2-phenylpropanoate <=> 4-methoxy-4-oxo-3-phenylbutanoate + NH4(+)"}
{"X":36713,"RHEA_ID":44811,"compounds":"1,4-dihydroxy-2-naphthoate + all-trans-decaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-10 + CO2 + diphosphate"}
{"X":36714,"RHEA_ID":34884,"DIRECTION":"LR","MASTER_ID":34883,"ecocyc":"TRANS-RXN0-478","compounds":"ATP + H2O + selenate(out) => ADP + H(+) + phosphate + selenate(in)"}
{"X":36715,"RHEA_ID":34885,"compounds":"ADP + H(+) + phosphate + selenate(in) => ATP + H2O + selenate(out)"}
{"X":36716,"RHEA_ID":34886,"compounds":"ATP + H2O + selenate(out) <=> ADP + H(+) + phosphate + selenate(in)"}
{"X":36717,"RHEA_ID":34887,"compounds":"selenate(in) = selenate(out)"}
{"X":36718,"RHEA_ID":34888,"compounds":"selenate(in) => selenate(out)"}
{"X":36719,"RHEA_ID":44817,"DIRECTION":"LR","MASTER_ID":44816,"metacyc":"RXN-9360","compounds":"1,4-dihydroxy-2-naphthoate + all-trans-dodecaprenyl diphosphate + H(+) => 2-demethylmenaquinol-12 + CO2 + diphosphate"}
{"X":36720,"RHEA_ID":34890,"compounds":"selenate(in) <=> selenate(out)"}
{"X":36721,"RHEA_ID":34891,"compounds":"selenite(in) = selenite(out)"}
{"X":36722,"RHEA_ID":34892,"compounds":"selenite(in) => selenite(out)"}
{"X":36723,"RHEA_ID":44821,"DIRECTION":"LR","MASTER_ID":44820,"metacyc":"RXN-9365","compounds":"1,4-dihydroxy-2-naphthoate + all-trans-tridecaprenyl diphosphate + H(+) => 2-demethylmenaquinol-13 + CO2 + diphosphate"}
{"X":36724,"RHEA_ID":34894,"compounds":"selenite(in) <=> selenite(out)"}
{"X":36725,"RHEA_ID":34895,"compounds":"ATP + H2O + selenite(out) = ADP + H(+) + phosphate + selenite(in)"}
{"X":36726,"RHEA_ID":44824,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol = a 1,2-diacylglycerol + a monoacyl-sn-glycero-3-phosphocholine"}
{"X":36727,"RHEA_ID":44825,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol => a 1,2-diacylglycerol + a monoacyl-sn-glycero-3-phosphocholine"}
{"X":36728,"RHEA_ID":34898,"compounds":"ATP + H2O + selenite(out) <=> ADP + H(+) + phosphate + selenite(in)"}
{"X":36729,"RHEA_ID":34899,"compounds":"malonyl-CoA + S-adenosyl-L-methionine = malonyl-CoA methyl ester + S-adenosyl-L-homocysteine"}
{"X":36730,"RHEA_ID":44828,"compounds":"(R)-carnitine + decanoyl-CoA = CoA + O-decanoyl-(R)-carnitine"}
{"X":36731,"RHEA_ID":44829,"compounds":"(R)-carnitine + decanoyl-CoA => CoA + O-decanoyl-(R)-carnitine"}
{"X":36732,"RHEA_ID":34902,"compounds":"malonyl-CoA + S-adenosyl-L-methionine <=> malonyl-CoA methyl ester + S-adenosyl-L-homocysteine"}
{"X":36733,"RHEA_ID":34903,"compounds":"4 glutathione + 2 H(+) + selenite = glutathione disulfide + 3 H2O + selenodiglutathione"}
{"X":36734,"RHEA_ID":34904,"DIRECTION":"LR","MASTER_ID":34903,"ecocyc":"RXN-12864","metacyc":"RXN-12864","reactome":"R-HSA-2408556.1","compounds":"4 glutathione + 2 H(+) + selenite => glutathione disulfide + 3 H2O + selenodiglutathione"}
{"X":36735,"RHEA_ID":44833,"compounds":"(R)-carnitine + tetradecanoyl-CoA => CoA + O-tetradecanoyl-(R)-carnitine"}
{"X":36736,"RHEA_ID":34906,"compounds":"4 glutathione + 2 H(+) + selenite <=> glutathione disulfide + 3 H2O + selenodiglutathione"}
{"X":36737,"RHEA_ID":34907,"compounds":"molybdate(in) = molybdate(out)"}
{"X":36738,"RHEA_ID":44836,"compounds":"globoside NORint (d18:1(4E)) + UDP-alpha-D-galactose = globoside NOR2 (d18:1(4E)) + H(+) + UDP"}
{"X":36739,"RHEA_ID":44837,"compounds":"globoside NORint (d18:1(4E)) + UDP-alpha-D-galactose => globoside NOR2 (d18:1(4E)) + H(+) + UDP"}
{"X":36740,"RHEA_ID":34910,"compounds":"molybdate(in) <=> molybdate(out)"}
{"X":36741,"RHEA_ID":34911,"compounds":"D-methionine(in) = D-methionine(out)"}
{"X":36742,"RHEA_ID":44840,"compounds":"(R)-carnitine + octadecanoyl-CoA = CoA + O-octadecanoyl-(R)-carnitine"}
{"X":36743,"RHEA_ID":34913,"compounds":"D-methionine(out) => D-methionine(in)"}
{"X":36744,"RHEA_ID":34914,"compounds":"D-methionine(in) <=> D-methionine(out)"}
{"X":36745,"RHEA_ID":34915,"compounds":"D-galactose(in) = D-galactose(out)"}
{"X":36746,"RHEA_ID":44844,"compounds":"(R)-carnitine + eicosanoyl-CoA = CoA + O-eicosanoyl-(R)-carnitine"}
{"X":36747,"RHEA_ID":34917,"compounds":"D-galactose(out) => D-galactose(in)"}
{"X":36748,"RHEA_ID":34918,"compounds":"D-galactose(in) <=> D-galactose(out)"}
{"X":36749,"RHEA_ID":34919,"compounds":"thiamine(in) = thiamine(out)"}
{"X":36750,"RHEA_ID":44848,"compounds":"(9Z)-tetradecenoyl-CoA + (R)-carnitine = CoA + O-(9Z)-tetradecenoyl-(R)-carnitine"}
{"X":36751,"RHEA_ID":44849,"compounds":"(9Z)-tetradecenoyl-CoA + (R)-carnitine => CoA + O-(9Z)-tetradecenoyl-(R)-carnitine"}
{"X":36752,"RHEA_ID":34922,"compounds":"thiamine(in) <=> thiamine(out)"}
{"X":36753,"RHEA_ID":34923,"compounds":"nitrate(in) = nitrate(out)"}
{"X":36754,"RHEA_ID":44852,"compounds":"(5Z)-tetradecenoyl-CoA + (R)-carnitine = CoA + O-(5Z)-tetradecenoyl-(R)-carnitine"}
{"X":36755,"RHEA_ID":44853,"compounds":"(5Z)-tetradecenoyl-CoA + (R)-carnitine => CoA + O-(5Z)-tetradecenoyl-(R)-carnitine"}
{"X":36756,"RHEA_ID":34926,"compounds":"nitrate(in) <=> nitrate(out)"}
{"X":36757,"RHEA_ID":34927,"compounds":"H(+) + NADPH + selenodiglutathione = glutathione + glutathioselenol + NADP(+)"}
{"X":36758,"RHEA_ID":44856,"compounds":"(9Z)-octadecenoyl-CoA + (R)-carnitine = CoA + O-(9Z)-octadecenoyl-(R)-carnitine"}
{"X":36759,"RHEA_ID":44857,"compounds":"(9Z)-octadecenoyl-CoA + (R)-carnitine => CoA + O-(9Z)-octadecenoyl-(R)-carnitine"}
{"X":36760,"RHEA_ID":34930,"compounds":"H(+) + NADPH + selenodiglutathione <=> glutathione + glutathioselenol + NADP(+)"}
{"X":36761,"RHEA_ID":34931,"compounds":"glutathioselenol + NADPH = glutathione + hydrogenselenide + NADP(+)"}
{"X":36762,"RHEA_ID":34932,"DIRECTION":"LR","MASTER_ID":34931,"metacyc":"RXN-12867","compounds":"glutathioselenol + NADPH => glutathione + hydrogenselenide + NADP(+)"}
{"X":36763,"RHEA_ID":44861,"compounds":"(R)-carnitine + 4,8-dimethylnonanoyl-CoA => CoA + O-4,8-dimethylnonanoyl-(R)-carnitine"}
{"X":36764,"RHEA_ID":34934,"compounds":"glutathioselenol + NADPH <=> glutathione + hydrogenselenide + NADP(+)"}
{"X":36765,"RHEA_ID":34935,"compounds":"2 ATP + H(+) = diphosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate"}
{"X":36766,"RHEA_ID":34936,"compounds":"2 ATP + H(+) => diphosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate"}
{"X":36767,"RHEA_ID":44865,"compounds":"a triacyl-sn-glycerol + H2O => a 1,2-diacylglycerol + a fatty acid + H(+)"}
{"X":36768,"RHEA_ID":34938,"DIRECTION":"BI","MASTER_ID":34935,"ecocyc":"RXN0-5208","metacyc":"RXN0-5208","compounds":"2 ATP + H(+) <=> diphosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate"}
{"X":36769,"RHEA_ID":34939,"DIRECTION":"UN","MASTER_ID":34939,"ec":"1.97.1.9","compounds":"H2O + menaquinone-8 + selenite = menaquinol-8 + selenate"}
{"X":36770,"RHEA_ID":44868,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + ethanol = 1,2-diacyl-sn-glycero-3-phosphoethanol + choline"}
{"X":36771,"RHEA_ID":34941,"compounds":"menaquinol-8 + selenate => H2O + menaquinone-8 + selenite"}
{"X":36772,"RHEA_ID":34942,"compounds":"H2O + menaquinone-8 + selenite <=> menaquinol-8 + selenate"}
{"X":36773,"RHEA_ID":34943,"compounds":"hydroquinone O-beta-D-glucopyranoside(out) + phosphoenolpyruvate(in) = arbutin 6-phosphate(in) + pyruvate(in)"}
{"X":36774,"RHEA_ID":44872,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)"}
{"X":36775,"RHEA_ID":44873,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)"}
{"X":36776,"RHEA_ID":34946,"compounds":"hydroquinone O-beta-D-glucopyranoside(out) + phosphoenolpyruvate(in) <=> arbutin 6-phosphate(in) + pyruvate(in)"}
{"X":36777,"RHEA_ID":34947,"compounds":"(Z)-3-aminoacrylate + H(+) + H2O = 3-oxopropanoate + NH4(+)"}
{"X":36778,"RHEA_ID":34948,"DIRECTION":"LR","MASTER_ID":34947,"ecocyc":"RXN0-6452","metacyc":"RXN0-6452","compounds":"(Z)-3-aminoacrylate + H(+) + H2O => 3-oxopropanoate + NH4(+)"}
{"X":36779,"RHEA_ID":44877,"compounds":"a 1,3-diacylglycerol + H2O => 3-acyl-sn-glycerol + a fatty acid + H(+)"}
{"X":36780,"RHEA_ID":34950,"compounds":"(Z)-3-aminoacrylate + H(+) + H2O <=> 3-oxopropanoate + NH4(+)"}
{"X":36781,"RHEA_ID":34951,"compounds":"3-hydroxypropanoate(out) = 3-hydroxypropanoate(in)"}
{"X":36782,"RHEA_ID":34952,"compounds":"3-hydroxypropanoate(out) => 3-hydroxypropanoate(in)"}
{"X":36783,"RHEA_ID":44881,"compounds":"[receptor-protein]-L-threonine + ATP => [receptor-protein]-O-phospho-L-threonine + ADP + H(+)"}
{"X":36784,"RHEA_ID":34954,"compounds":"3-hydroxypropanoate(out) <=> 3-hydroxypropanoate(in)"}
{"X":36785,"RHEA_ID":34955,"compounds":"S-methyl-5-thio-D-ribose(in) = S-methyl-5-thio-D-ribose(out)"}
{"X":36786,"RHEA_ID":44888,"compounds":"1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-sn-glycero-3-phosphate + a fatty acid + H(+)"}
{"X":36787,"RHEA_ID":34957,"compounds":"S-methyl-5-thio-D-ribose(out) => S-methyl-5-thio-D-ribose(in)"}
{"X":36788,"RHEA_ID":34958,"compounds":"S-methyl-5-thio-D-ribose(in) <=> S-methyl-5-thio-D-ribose(out)"}
{"X":36789,"RHEA_ID":34959,"compounds":"(R)-carnitine(in) = (R)-carnitine(out)"}
{"X":36790,"RHEA_ID":44892,"compounds":"an N-(2-hydroxyacyl)-sphinganine + UDP-alpha-D-galactose = an N-(2-hydroxyacyl)-beta-D-galactosyl-sphinganine + H(+) + UDP"}
{"X":36791,"RHEA_ID":44893,"compounds":"an N-(2-hydroxyacyl)-sphinganine + UDP-alpha-D-galactose => an N-(2-hydroxyacyl)-beta-D-galactosyl-sphinganine + H(+) + UDP"}
{"X":36792,"RHEA_ID":34962,"compounds":"(R)-carnitine(in) <=> (R)-carnitine(out)"}
{"X":36793,"RHEA_ID":34963,"compounds":"Na(+)(in) = Na(+)(out)"}
{"X":36794,"RHEA_ID":44896,"compounds":"a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose = H(+) + N-(2-hydroxyacyl)-beta-D-galactosyl-sphing-4-enine + UDP"}
{"X":36795,"RHEA_ID":44897,"compounds":"a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose => H(+) + N-(2-hydroxyacyl)-beta-D-galactosyl-sphing-4-enine + UDP"}
{"X":36796,"RHEA_ID":34964,"DIRECTION":"LR","MASTER_ID":34963,"reactome":"R-HSA-5576895.5","compounds":"Na(+)(in) => Na(+)(out)"}
{"X":36797,"RHEA_ID":34964,"DIRECTION":"LR","MASTER_ID":34963,"reactome":"R-HSA-451310.2","compounds":"Na(+)(in) => Na(+)(out)"}
{"X":36798,"RHEA_ID":44900,"DIRECTION":"UN","MASTER_ID":44900,"ec":"3.1.1.25","compounds":"D-galactono-1,4-lactone + H2O = D-galactonate + H(+)"}
{"X":36799,"RHEA_ID":44901,"DIRECTION":"LR","MASTER_ID":44900,"ecocyc":"GALACTONOLACTONASE-RXN","metacyc":"GALACTONOLACTONASE-RXN","compounds":"D-galactono-1,4-lactone + H2O => D-galactonate + H(+)"}
{"X":36800,"RHEA_ID":34964,"DIRECTION":"LR","MASTER_ID":34963,"reactome":"R-HSA-622325.2","compounds":"Na(+)(in) => Na(+)(out)"}
{"X":36801,"RHEA_ID":34964,"DIRECTION":"LR","MASTER_ID":34963,"reactome":"R-HSA-2671885.3","compounds":"Na(+)(in) => Na(+)(out)"}
{"X":36802,"RHEA_ID":44904,"DIRECTION":"UN","MASTER_ID":44904,"ec":"3.1.3.9","compounds":"alpha-D-glucose 6-phosphate + H2O = alpha-D-glucose + phosphate"}
{"X":36803,"RHEA_ID":44904,"DIRECTION":"UN","MASTER_ID":44904,"ec":"3.1.3.58","compounds":"alpha-D-glucose 6-phosphate + H2O = alpha-D-glucose + phosphate"}
{"X":36804,"RHEA_ID":34965,"DIRECTION":"RL","MASTER_ID":34963,"reactome":"R-HSA-2730664.2","compounds":"Na(+)(out) => Na(+)(in)"}
{"X":36805,"RHEA_ID":34966,"compounds":"Na(+)(in) <=> Na(+)(out)"}
{"X":36806,"RHEA_ID":44905,"DIRECTION":"LR","MASTER_ID":44904,"ecocyc":"RXN-15312","metacyc":"RXN-15312","reactome":"R-HSA-3266566.3","compounds":"alpha-D-glucose 6-phosphate + H2O => alpha-D-glucose + phosphate"}
{"X":36807,"RHEA_ID":34968,"compounds":"sn-glycerol 3-phosphate(in) => sn-glycerol 3-phosphate(out)"}
{"X":36808,"RHEA_ID":34969,"compounds":"sn-glycerol 3-phosphate(out) => sn-glycerol 3-phosphate(in)"}
{"X":36809,"RHEA_ID":34970,"compounds":"sn-glycerol 3-phosphate(in) <=> sn-glycerol 3-phosphate(out)"}
{"X":36810,"RHEA_ID":44913,"compounds":"(2E,4E)-hexadienoyl-CoA + H(+) + NADPH => (3E)-hexenoyl-CoA + NADP(+)"}
{"X":36811,"RHEA_ID":44914,"compounds":"(3E)-hexenoyl-CoA + NADP(+) => (2E,4E)-hexadienoyl-CoA + H(+) + NADPH"}
{"X":36812,"RHEA_ID":34973,"compounds":"Fe(3+)(out) => Fe(3+)(in)"}
{"X":36813,"RHEA_ID":34974,"compounds":"Fe(3+)(in) <=> Fe(3+)(out)"}
{"X":36814,"RHEA_ID":44917,"compounds":"(2E,4E)-decadienoyl-CoA + H(+) + NADPH => (3E)-decenoyl-CoA + NADP(+)"}
{"X":36815,"RHEA_ID":34976,"compounds":"(R)-pantothenate(in) => (R)-pantothenate(out)"}
{"X":36816,"RHEA_ID":34977,"compounds":"(R)-pantothenate(out) => (R)-pantothenate(in)"}
{"X":36817,"RHEA_ID":34978,"compounds":"(R)-pantothenate(in) <=> (R)-pantothenate(out)"}
{"X":36818,"RHEA_ID":44921,"compounds":"(2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + H(+) + NADPH => (3E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + NADP(+)"}
{"X":36819,"RHEA_ID":44922,"compounds":"(3E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + NADP(+) => (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + H(+) + NADPH"}
{"X":36820,"RHEA_ID":34980,"DIRECTION":"LR","MASTER_ID":34979,"reactome":"R-HSA-170026.4","compounds":"H(+)(in) => H(+)(out)"}
{"X":36821,"RHEA_ID":34980,"DIRECTION":"LR","MASTER_ID":34979,"reactome":"R-HSA-6788999.2","compounds":"H(+)(in) => H(+)(out)"}
{"X":36822,"RHEA_ID":44925,"DIRECTION":"LR","MASTER_ID":44924,"metacyc":"R211-RXN","compounds":"2-oxoadipate + acetyl-CoA + H2O => (R)-dihomocitrate + CoA + H(+)"}
{"X":36823,"RHEA_ID":34982,"compounds":"H(+)(in) <=> H(+)(out)"}
{"X":36824,"RHEA_ID":34983,"compounds":"sulfate(in) = sulfate(out)"}
{"X":36825,"RHEA_ID":34984,"DIRECTION":"LR","MASTER_ID":34983,"reactome":"R-HSA-8875871.1","compounds":"sulfate(in) => sulfate(out)"}
{"X":36826,"RHEA_ID":44929,"DIRECTION":"LR","MASTER_ID":44928,"metacyc":"R215-RXN","compounds":"2-oxoheptanedioate + acetyl-CoA + H2O => (R)-trihomocitrate + CoA + H(+)"}
{"X":36827,"RHEA_ID":44930,"compounds":"(R)-trihomocitrate + CoA + H(+) => 2-oxoheptanedioate + acetyl-CoA + H2O"}
{"X":36828,"RHEA_ID":34987,"compounds":"(S)-lactate(in) = (S)-lactate(out)"}
{"X":36829,"RHEA_ID":34988,"compounds":"(S)-lactate(in) => (S)-lactate(out)"}
{"X":36830,"RHEA_ID":34989,"compounds":"(S)-lactate(out) => (S)-lactate(in)"}
{"X":36831,"RHEA_ID":34990,"compounds":"(S)-lactate(in) <=> (S)-lactate(out)"}
{"X":36832,"RHEA_ID":34991,"compounds":"L-arginine(out) + L-ornithine(in) = L-arginine(in) + L-ornithine(out)"}
{"X":36833,"RHEA_ID":34992,"compounds":"L-arginine(out) + L-ornithine(in) => L-arginine(in) + L-ornithine(out)"}
{"X":36834,"RHEA_ID":44937,"compounds":"(9Z,12Z,15Z)-octadecatrienoate + ATP + CoA => (9Z,12Z,15Z)-octadecatrienoyl-CoA + AMP + diphosphate"}
{"X":36835,"RHEA_ID":44938,"compounds":"(9Z,12Z,15Z)-octadecatrienoyl-CoA + AMP + diphosphate => (9Z,12Z,15Z)-octadecatrienoate + ATP + CoA"}
{"X":36836,"RHEA_ID":34995,"compounds":"L-rhamnose(in) = L-rhamnose(out)"}
{"X":36837,"RHEA_ID":34996,"compounds":"L-rhamnose(in) => L-rhamnose(out)"}
{"X":36838,"RHEA_ID":44941,"compounds":"1-O-alkyl-2,3-diacyl-sn-glycerol + H2O => 1-O-alkyl-3-acyl-sn-glycerol + a fatty acid + H(+)"}
{"X":36839,"RHEA_ID":44942,"compounds":"1-O-alkyl-3-acyl-sn-glycerol + a fatty acid + H(+) => 1-O-alkyl-2,3-diacyl-sn-glycerol + H2O"}
{"X":36840,"RHEA_ID":34999,"compounds":"ADP(in) + ATP(out) = ADP(out) + ATP(in)"}
{"X":36841,"RHEA_ID":35000,"DIRECTION":"LR","MASTER_ID":34999,"reactome":"R-HSA-5672027.4","compounds":"ADP(in) + ATP(out) => ADP(out) + ATP(in)"}
{"X":36842,"RHEA_ID":44945,"compounds":"1-O-alkyl-3-acyl-sn-glycerol + H2O => 1-O-alkyl-sn-glycerol + a fatty acid + H(+)"}
{"X":36843,"RHEA_ID":44946,"compounds":"1-O-alkyl-sn-glycerol + a fatty acid + H(+) => 1-O-alkyl-3-acyl-sn-glycerol + H2O"}
{"X":36844,"RHEA_ID":35002,"compounds":"ADP(in) + ATP(out) <=> ADP(out) + ATP(in)"}
{"X":36845,"RHEA_ID":35003,"compounds":"L-fucose(in) = L-fucose(out)"}
{"X":36846,"RHEA_ID":44949,"compounds":"1-O-alkyl-2,3-diacyl-sn-glycerol + H2O => 1-O-alkyl-2-acyl-sn-glycerol + a fatty acid + H(+)"}
{"X":36847,"RHEA_ID":35005,"compounds":"L-fucose(out) => L-fucose(in)"}
{"X":36848,"RHEA_ID":44951,"compounds":"1-O-alkyl-2,3-diacyl-sn-glycerol + H2O <=> 1-O-alkyl-2-acyl-sn-glycerol + a fatty acid + H(+)"}
{"X":36849,"RHEA_ID":35007,"compounds":"D-fucose(in) = D-fucose(out)"}
{"X":36850,"RHEA_ID":44953,"compounds":"(2E)-octenoyl-CoA + H(+) + NADPH => NADP(+) + octanoyl-CoA"}
{"X":36851,"RHEA_ID":35009,"compounds":"D-fucose(out) => D-fucose(in)"}
{"X":36852,"RHEA_ID":44955,"compounds":"(2E)-octenoyl-CoA + H(+) + NADPH <=> NADP(+) + octanoyl-CoA"}
{"X":36853,"RHEA_ID":35011,"compounds":"D-fucose(in) + H(+)(in) = D-fucose(out) + H(+)(out)"}
{"X":36854,"RHEA_ID":35012,"compounds":"D-fucose(in) + H(+)(in) => D-fucose(out) + H(+)(out)"}
{"X":36855,"RHEA_ID":35013,"compounds":"D-fucose(out) + H(+)(out) => D-fucose(in) + H(+)(in)"}
{"X":36856,"RHEA_ID":44959,"compounds":"(2E)-hexenoyl-CoA + H(+) + NADPH <=> hexanoyl-CoA + NADP(+)"}
{"X":36857,"RHEA_ID":35015,"compounds":"riboflavin(in) = riboflavin(out)"}
{"X":36858,"RHEA_ID":35016,"DIRECTION":"LR","MASTER_ID":35015,"reactome":"R-HSA-3165230.3","compounds":"riboflavin(in) => riboflavin(out)"}
{"X":36859,"RHEA_ID":35017,"compounds":"riboflavin(out) => riboflavin(in)"}
{"X":36860,"RHEA_ID":35018,"compounds":"riboflavin(in) <=> riboflavin(out)"}
{"X":36861,"RHEA_ID":44964,"compounds":"(2E)-dodecenoyl-CoA + H(+) + NADPH = dodecanoyl-CoA + NADP(+)"}
{"X":36862,"RHEA_ID":44965,"compounds":"(2E)-dodecenoyl-CoA + H(+) + NADPH => dodecanoyl-CoA + NADP(+)"}
{"X":36863,"RHEA_ID":35021,"compounds":"L-threonine(out) => L-threonine(in)"}
{"X":36864,"RHEA_ID":35022,"compounds":"L-threonine(in) <=> L-threonine(out)"}
{"X":36865,"RHEA_ID":35023,"compounds":"hydroquinone O-beta-D-glucopyranoside(out) = hydroquinone O-beta-D-glucopyranoside(in)"}
{"X":36866,"RHEA_ID":44969,"compounds":"(2E)-tetradecenoyl-CoA + H(+) + NADPH => NADP(+) + tetradecanoyl-CoA"}
{"X":36867,"RHEA_ID":35025,"compounds":"hydroquinone O-beta-D-glucopyranoside(in) => hydroquinone O-beta-D-glucopyranoside(out)"}
{"X":36868,"RHEA_ID":35026,"compounds":"hydroquinone O-beta-D-glucopyranoside(out) <=> hydroquinone O-beta-D-glucopyranoside(in)"}
{"X":36869,"RHEA_ID":35027,"DIRECTION":"UN","MASTER_ID":35027,"ec":"7.3.2.6","compounds":"ATP + H2O + tungstate(in) = ADP + H(+) + phosphate + tungstate(out)"}
{"X":36870,"RHEA_ID":44973,"compounds":"(R)-carnitine + hexanoyl-CoA => CoA + O-hexanoyl-(R)-carnitine"}
{"X":36871,"RHEA_ID":44974,"compounds":"CoA + O-hexanoyl-(R)-carnitine => (R)-carnitine + hexanoyl-CoA"}
{"X":36872,"RHEA_ID":44975,"compounds":"(R)-carnitine + hexanoyl-CoA <=> CoA + O-hexanoyl-(R)-carnitine"}
{"X":36873,"RHEA_ID":35031,"compounds":"L-serine(in) = L-serine(out)"}
{"X":36874,"RHEA_ID":44977,"compounds":"(R)-carnitine + propanoyl-CoA => CoA + O-propanoyl-(R)-carnitine"}
{"X":36875,"RHEA_ID":44978,"compounds":"CoA + O-propanoyl-(R)-carnitine => (R)-carnitine + propanoyl-CoA"}
{"X":36876,"RHEA_ID":35034,"compounds":"L-serine(in) <=> L-serine(out)"}
{"X":36877,"RHEA_ID":35035,"compounds":"4-aminobutanoate(in) = 4-aminobutanoate(out)"}
{"X":36878,"RHEA_ID":44981,"compounds":"(R)-carnitine + butanoyl-CoA => CoA + O-butanoyl-(R)-carnitine"}
{"X":36879,"RHEA_ID":44982,"compounds":"CoA + O-butanoyl-(R)-carnitine => (R)-carnitine + butanoyl-CoA"}
{"X":36880,"RHEA_ID":35038,"compounds":"4-aminobutanoate(in) <=> 4-aminobutanoate(out)"}
{"X":36881,"RHEA_ID":35039,"compounds":"spermidine(in) = spermidine(out)"}
{"X":36882,"RHEA_ID":44985,"compounds":"(R)-carnitine + 3-methylbutanoyl-CoA => CoA + O-3-methylbutanoyl-(R)-carnitine"}
{"X":36883,"RHEA_ID":35041,"DIRECTION":"RL","MASTER_ID":35039,"reactome":"R-HSA-549322.1","compounds":"spermidine(out) => spermidine(in)"}
{"X":36884,"RHEA_ID":35042,"compounds":"spermidine(in) <=> spermidine(out)"}
{"X":36885,"RHEA_ID":35043,"compounds":"N-(4-aminobenzoyl)-L-glutamate(in) = N-(4-aminobenzoyl)-L-glutamate(out)"}
{"X":36886,"RHEA_ID":44989,"compounds":"(R)-carnitine + 2-methylpropanoyl-CoA => CoA + O-isobutanoyl-(R)-carnitine"}
{"X":36887,"RHEA_ID":44990,"compounds":"CoA + O-isobutanoyl-(R)-carnitine => (R)-carnitine + 2-methylpropanoyl-CoA"}
{"X":36888,"RHEA_ID":35046,"compounds":"N-(4-aminobenzoyl)-L-glutamate(in) <=> N-(4-aminobenzoyl)-L-glutamate(out)"}
{"X":36889,"RHEA_ID":35047,"DIRECTION":"UN","MASTER_ID":35047,"ec":"2.10.1.1","compounds":"adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin"}
{"X":36890,"RHEA_ID":44993,"compounds":"(R)-carnitine + 2-methylbutanoyl-CoA => CoA + O-2-methylbutanoyl-(R)-carnitine"}
{"X":36891,"RHEA_ID":35049,"compounds":"AMP + H2O + Mo-molybdopterin => adenylyl-molybdopterin + H(+) + molybdate"}
{"X":36892,"RHEA_ID":44995,"compounds":"(R)-carnitine + 2-methylbutanoyl-CoA <=> CoA + O-2-methylbutanoyl-(R)-carnitine"}
{"X":36893,"RHEA_ID":35051,"compounds":"N,N'-diacetylchitobiose(out) = N,N'-diacetylchitobiose(in)"}
{"X":36894,"RHEA_ID":35052,"compounds":"N,N'-diacetylchitobiose(out) => N,N'-diacetylchitobiose(in)"}
{"X":36895,"RHEA_ID":44998,"compounds":"CoA + O-3-oxobutanoyl-(R)-carnitine => (R)-carnitine + acetoacetyl-CoA"}
{"X":36896,"RHEA_ID":35054,"compounds":"N,N'-diacetylchitobiose(out) <=> N,N'-diacetylchitobiose(in)"}
{"X":36897,"RHEA_ID":35055,"compounds":"3,6-dichlorocatechol + O2 = (2E,4E)-2,5-dichloromuconate + H(+)"}
{"X":36898,"RHEA_ID":45001,"compounds":"(R)-carnitine + 3-hydroxybutanoyl-CoA => CoA + O-3-hydroxybutanoyl-(R)-carnitine"}
{"X":36899,"RHEA_ID":35057,"compounds":"(2E,4E)-2,5-dichloromuconate + H(+) => 3,6-dichlorocatechol + O2"}
{"X":36900,"RHEA_ID":45003,"compounds":"(R)-carnitine + 3-hydroxybutanoyl-CoA <=> CoA + O-3-hydroxybutanoyl-(R)-carnitine"}
{"X":36901,"RHEA_ID":35059,"compounds":"chloramphenicol(in) + H(+)(out) = chloramphenicol(out) + H(+)(in)"}
{"X":36902,"RHEA_ID":45005,"compounds":"(R)-carnitine + 2,6-dimethylheptanoyl-CoA => CoA + O-2,6-dimethylheptanoyl-(R)-carnitine"}
{"X":36903,"RHEA_ID":35061,"compounds":"chloramphenicol(out) + H(+)(in) => chloramphenicol(in) + H(+)(out)"}
{"X":36904,"RHEA_ID":35062,"compounds":"chloramphenicol(in) + H(+)(out) <=> chloramphenicol(out) + H(+)(in)"}
{"X":36905,"RHEA_ID":35063,"compounds":"H2O + pyrazinamide = NH4(+) + pyrazine-2-carboxylate"}
{"X":36906,"RHEA_ID":35064,"DIRECTION":"LR","MASTER_ID":35063,"ecocyc":"PYRAZIN-RXN","metacyc":"PYRAZIN-RXN","compounds":"H2O + pyrazinamide => NH4(+) + pyrazine-2-carboxylate"}
{"X":36907,"RHEA_ID":35065,"compounds":"NH4(+) + pyrazine-2-carboxylate => H2O + pyrazinamide"}
{"X":36908,"RHEA_ID":45011,"compounds":"H2O + N-(octadecanoyl)-sphinganine <=> octadecanoate + sphinganine"}
{"X":36909,"RHEA_ID":35067,"compounds":"(S)-carnitine(out) = (S)-carnitine(in)"}
{"X":36910,"RHEA_ID":45013,"compounds":"H2O + N-(octadecanoyl)-4-hydroxysphinganine => 4-hydroxysphinganine + octadecanoate"}
{"X":36911,"RHEA_ID":35069,"compounds":"(S)-carnitine(in) => (S)-carnitine(out)"}
{"X":36912,"RHEA_ID":45015,"compounds":"H2O + N-(octadecanoyl)-4-hydroxysphinganine <=> 4-hydroxysphinganine + octadecanoate"}
{"X":36913,"RHEA_ID":35071,"compounds":"4-methylphenol(in) = 4-methylphenol(out)"}
{"X":36914,"RHEA_ID":35072,"DIRECTION":"LR","MASTER_ID":35071,"ecocyc":"TRANS-RXN0-500","compounds":"4-methylphenol(in) => 4-methylphenol(out)"}
{"X":36915,"RHEA_ID":35073,"compounds":"4-methylphenol(out) => 4-methylphenol(in)"}
{"X":36916,"RHEA_ID":55002,"compounds":"3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n+1)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine"}
{"X":36917,"RHEA_ID":35075,"compounds":"doxorubicin(in) + H(+)(out) = doxorubicin(out) + H(+)(in)"}
{"X":36918,"RHEA_ID":35076,"compounds":"doxorubicin(in) + H(+)(out) => doxorubicin(out) + H(+)(in)"}
{"X":36919,"RHEA_ID":35077,"compounds":"doxorubicin(out) + H(+)(in) => doxorubicin(in) + H(+)(out)"}
{"X":36920,"RHEA_ID":35078,"compounds":"doxorubicin(in) + H(+)(out) <=> doxorubicin(out) + H(+)(in)"}
{"X":36921,"RHEA_ID":45024,"DIRECTION":"UN","MASTER_ID":45024,"ec":"1.14.19.21","compounds":"cholesterol + H(+) + NADPH + O2 = cholesta-5,7-dien-3beta-ol + 2 H2O + NADP(+)"}
{"X":36922,"RHEA_ID":35080,"compounds":"doxorubicin(in) => doxorubicin(out)"}
{"X":36923,"RHEA_ID":35081,"compounds":"doxorubicin(out) => doxorubicin(in)"}
{"X":36924,"RHEA_ID":35082,"compounds":"doxorubicin(in) <=> doxorubicin(out)"}
{"X":36925,"RHEA_ID":45028,"DIRECTION":"UN","MASTER_ID":45028,"ec":"1.3.8.12","compounds":"(2S)-methylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = 2-methylfumaryl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":36926,"RHEA_ID":35084,"DIRECTION":"LR","MASTER_ID":35083,"ecocyc":"RXN0-7001","metacyc":"RXN0-7001","compounds":"diacetylchitobiose-6'-phosphate + H2O => acetate + N'-monoacetylchitobiose-6'-phosphate"}
{"X":36927,"RHEA_ID":35085,"compounds":"acetate + N'-monoacetylchitobiose-6'-phosphate => diacetylchitobiose-6'-phosphate + H2O"}
{"X":36928,"RHEA_ID":35086,"compounds":"diacetylchitobiose-6'-phosphate + H2O <=> acetate + N'-monoacetylchitobiose-6'-phosphate"}
{"X":36929,"RHEA_ID":55015,"compounds":"(1S,4R)-1-hydroxylimonen-2-one + NADPH + O2 <=> (3R)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)"}
{"X":36930,"RHEA_ID":35088,"DIRECTION":"LR","MASTER_ID":35087,"ecocyc":"RXN0-7002","metacyc":"RXN0-7002","compounds":"H2O + N'-monoacetylchitobiose-6'-phosphate => D-glucosamine + N-acetyl-D-glucosamine 6-phosphate"}
{"X":36931,"RHEA_ID":35089,"compounds":"D-glucosamine + N-acetyl-D-glucosamine 6-phosphate => H2O + N'-monoacetylchitobiose-6'-phosphate"}
{"X":36932,"RHEA_ID":35090,"compounds":"H2O + N'-monoacetylchitobiose-6'-phosphate <=> D-glucosamine + N-acetyl-D-glucosamine 6-phosphate"}
{"X":36933,"RHEA_ID":45036,"DIRECTION":"UN","MASTER_ID":45036,"ec":"1.7.2.6","compounds":"3 [Fe(III)cytochrome c] + hydroxylamine = 3 [Fe(II)cytochrome c] + 3 H(+) + nitric oxide"}
{"X":36934,"RHEA_ID":35092,"DIRECTION":"LR","MASTER_ID":35091,"metacyc":"RXN-13989","compounds":"anthranilate + 2 ATP + L-phenylalanine + S-adenosyl-L-methionine => 2 AMP + cyclopeptine + 2 diphosphate + 2 H(+) + S-adenosyl-L-homocysteine"}
{"X":36935,"RHEA_ID":35093,"compounds":"2 AMP + cyclopeptine + 2 diphosphate + 2 H(+) + S-adenosyl-L-homocysteine => anthranilate + 2 ATP + L-phenylalanine + S-adenosyl-L-methionine"}
{"X":36936,"RHEA_ID":35095,"DIRECTION":"UN","MASTER_ID":35095,"ec":"4.3.99.4","compounds":"choline = acetaldehyde + trimethylamine"}
{"X":36937,"RHEA_ID":35096,"DIRECTION":"LR","MASTER_ID":35095,"metacyc":"RXN-13946","compounds":"choline => acetaldehyde + trimethylamine"}
{"X":36938,"RHEA_ID":35097,"compounds":"acetaldehyde + trimethylamine => choline"}
{"X":36939,"RHEA_ID":45044,"compounds":"2 [Fe(II)cytochrome c] + H(+) + nitroxyl + O2 = 2 [Fe(III)cytochrome c] + H2O + nitrite"}
{"X":36940,"RHEA_ID":35100,"compounds":"fusidate(in) + H(+)(out) => fusidate(out) + H(+)(in)"}
{"X":36941,"RHEA_ID":35101,"compounds":"fusidate(out) + H(+)(in) => fusidate(in) + H(+)(out)"}
{"X":36942,"RHEA_ID":35102,"compounds":"fusidate(in) + H(+)(out) <=> fusidate(out) + H(+)(in)"}
{"X":36943,"RHEA_ID":38433,"compounds":"(9Z)-octadecenoate + 2-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+) => 1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O"}
{"X":36944,"RHEA_ID":35104,"compounds":"fusidate(in) => fusidate(out)"}
{"X":36945,"RHEA_ID":35105,"compounds":"fusidate(out) => fusidate(in)"}
{"X":36946,"RHEA_ID":35106,"compounds":"fusidate(in) <=> fusidate(out)"}
{"X":36947,"RHEA_ID":38437,"compounds":"1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1,3-di-(9Z-octadecenoyl)-glycerol"}
{"X":36948,"RHEA_ID":35108,"compounds":"3-nitrotyramine + H2O + O2 => 4-hydroxy-3-nitrophenylacetaldehyde + H2O2 + NH4(+)"}
{"X":36949,"RHEA_ID":35109,"compounds":"4-hydroxy-3-nitrophenylacetaldehyde + H2O2 + NH4(+) => 3-nitrotyramine + H2O + O2"}
{"X":36950,"RHEA_ID":35110,"compounds":"3-nitrotyramine + H2O + O2 <=> 4-hydroxy-3-nitrophenylacetaldehyde + H2O2 + NH4(+)"}
{"X":36951,"RHEA_ID":45056,"DIRECTION":"UN","MASTER_ID":45056,"ec":"1.13.12.22","compounds":"deoxynogalonate + O2 = H(+) + H2O + nogalonate"}
{"X":36952,"RHEA_ID":45057,"DIRECTION":"LR","MASTER_ID":45056,"metacyc":"RXN-16270","compounds":"deoxynogalonate + O2 => H(+) + H2O + nogalonate"}
{"X":36953,"RHEA_ID":35113,"compounds":"2,5-didehydro-D-gluconate + H(+) + NADPH => 2-dehydro-L-idonate + NADP(+)"}
{"X":36954,"RHEA_ID":35114,"compounds":"2-dehydro-L-idonate + NADP(+) <=> 2,5-didehydro-D-gluconate + H(+) + NADPH"}
{"X":36955,"RHEA_ID":45060,"compounds":"H2O + N-(9Z-octadecenoyl) ethanolamine = (9Z)-octadecenoate + ethanolamine"}
{"X":36956,"RHEA_ID":45061,"compounds":"H2O + N-(9Z-octadecenoyl) ethanolamine => (9Z)-octadecenoate + ethanolamine"}
{"X":36957,"RHEA_ID":35117,"compounds":"(4-coumaroyl)acetyl-CoA + CO2 + CoA => 4-coumaroyl-CoA + H(+) + malonyl-CoA"}
{"X":36958,"RHEA_ID":45063,"compounds":"H2O + N-(9Z-octadecenoyl) ethanolamine <=> (9Z)-octadecenoate + ethanolamine"}
{"X":36959,"RHEA_ID":45064,"compounds":"H2O + N-hexadecanoylethanolamine = ethanolamine + hexadecanoate"}
{"X":36960,"RHEA_ID":45065,"compounds":"H2O + N-hexadecanoylethanolamine => ethanolamine + hexadecanoate"}
{"X":36961,"RHEA_ID":35121,"compounds":"bisdemethoxycurcumin + CO2 + 2 CoA => (4-coumaroyl)acetyl-CoA + 4-coumaroyl-CoA + H2O"}
{"X":36962,"RHEA_ID":45067,"compounds":"H2O + N-hexadecanoylethanolamine <=> ethanolamine + hexadecanoate"}
{"X":36963,"RHEA_ID":45068,"compounds":"(R)-carnitine + an acyl-CoA = CoA + O-acyl-(R)-carnitine"}
{"X":36964,"RHEA_ID":45069,"compounds":"(R)-carnitine + an acyl-CoA => CoA + O-acyl-(R)-carnitine"}
{"X":36965,"RHEA_ID":35125,"compounds":"H(+)(in) + L-alanyl-D-glutamate(in) => H(+)(out) + L-alanyl-D-glutamate(out)"}
{"X":36966,"RHEA_ID":35126,"compounds":"H(+)(out) + L-alanyl-D-glutamate(out) <=> H(+)(in) + L-alanyl-D-glutamate(in)"}
{"X":36967,"RHEA_ID":45072,"DIRECTION":"UN","MASTER_ID":45072,"ec":"1.14.14.129","compounds":"(9Z)-octadecenoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase] = (9Z)-18-hydroxyoctadecenoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":36968,"RHEA_ID":35128,"compounds":"L-alanyl-D-glutamate(out) => L-alanyl-D-glutamate(in)"}
{"X":36969,"RHEA_ID":35129,"compounds":"L-alanyl-D-glutamate(in) => L-alanyl-D-glutamate(out)"}
{"X":36970,"RHEA_ID":35130,"compounds":"L-alanyl-D-glutamate(out) <=> L-alanyl-D-glutamate(in)"}
{"X":36971,"RHEA_ID":45076,"DIRECTION":"UN","MASTER_ID":45076,"ec":"1.14.14.129","compounds":"(9Z,12Z)-octadecadienoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase] = (9Z,12Z)-18-hydroxyoctadecadienoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":36972,"RHEA_ID":45077,"DIRECTION":"LR","MASTER_ID":45076,"metacyc":"RXN-16116","compounds":"(9Z,12Z)-octadecadienoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase] => (9Z,12Z)-18-hydroxyoctadecadienoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":36973,"RHEA_ID":35133,"compounds":"H(+)(in) + L-alanyl-L-glutamate(in) => H(+)(out) + L-alanyl-L-glutamate(out)"}
{"X":36974,"RHEA_ID":35134,"compounds":"H(+)(out) + L-alanyl-L-glutamate(out) <=> H(+)(in) + L-alanyl-L-glutamate(in)"}
{"X":36975,"RHEA_ID":45080,"DIRECTION":"UN","MASTER_ID":45080,"ec":"6.3.2.47","compounds":"3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine + ATP + L-valine = ADP + dapdiamide E + H(+) + phosphate"}
{"X":36976,"RHEA_ID":45081,"DIRECTION":"LR","MASTER_ID":45080,"metacyc":"RXN-16991","compounds":"3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine + ATP + L-valine => ADP + dapdiamide E + H(+) + phosphate"}
{"X":36977,"RHEA_ID":35137,"compounds":"L-alanyl-L-glutamate(in) => L-alanyl-L-glutamate(out)"}
{"X":36978,"RHEA_ID":35138,"compounds":"L-alanyl-L-glutamate(out) <=> L-alanyl-L-glutamate(in)"}
{"X":36979,"RHEA_ID":45084,"DIRECTION":"UN","MASTER_ID":45084,"ec":"1.14.14.130","compounds":"dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 7-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":36980,"RHEA_ID":45085,"DIRECTION":"LR","MASTER_ID":45084,"metacyc":"RXN-12186","compounds":"dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 7-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":36981,"RHEA_ID":35141,"compounds":"CO2 + 2 CoA + demethoxycurcumin => (E)-4-coumaroyl-CoA + (E)-feruloylacetyl-CoA + H2O"}
{"X":36982,"RHEA_ID":55070,"compounds":"a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 12-oxojasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":36983,"RHEA_ID":35143,"DIRECTION":"UN","MASTER_ID":35143,"ec":"2.3.1.220","compounds":"benzoyl-CoA + 2 H(+) + 3 malonyl-CoA = 2,4,6-trihydroxybenzophenone + 3 CO2 + 4 CoA"}
{"X":36984,"RHEA_ID":35144,"DIRECTION":"LR","MASTER_ID":35143,"metacyc":"RXN-7481","compounds":"benzoyl-CoA + 2 H(+) + 3 malonyl-CoA => 2,4,6-trihydroxybenzophenone + 3 CO2 + 4 CoA"}
{"X":36985,"RHEA_ID":35145,"compounds":"2,4,6-trihydroxybenzophenone + 3 CO2 + 4 CoA => benzoyl-CoA + 2 H(+) + 3 malonyl-CoA"}
{"X":36986,"RHEA_ID":45091,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine <=> 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline"}
{"X":36987,"RHEA_ID":45092,"compounds":"H2O + N-octanoylsphing-4-enine = octanoate + sphing-4-enine"}
{"X":36988,"RHEA_ID":35148,"DIRECTION":"LR","MASTER_ID":35147,"ecocyc":"TRANS-RXN0-453","compounds":"(2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(in) => (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(out)"}
{"X":36989,"RHEA_ID":35149,"compounds":"(2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(out) => (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(in)"}
{"X":36990,"RHEA_ID":35150,"compounds":"(2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(in) <=> (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(out)"}
{"X":36991,"RHEA_ID":35151,"compounds":"4-hydroxy-3-nitrophenylacetaldehyde + H2O + NAD(+) = (3-nitro-4-oxidophenyl)acetate + 2 H(+) + NADH"}
{"X":36992,"RHEA_ID":55080,"DIRECTION":"UN","MASTER_ID":55080,"ec":"2.4.1.13","compounds":"ADP-alpha-D-glucose + D-fructose = ADP + H(+) + sucrose"}
{"X":36993,"RHEA_ID":35153,"compounds":"(3-nitro-4-oxidophenyl)acetate + 2 H(+) + NADH => 4-hydroxy-3-nitrophenylacetaldehyde + H2O + NAD(+)"}
{"X":36994,"RHEA_ID":35154,"compounds":"4-hydroxy-3-nitrophenylacetaldehyde + H2O + NAD(+) <=> (3-nitro-4-oxidophenyl)acetate + 2 H(+) + NADH"}
{"X":36995,"RHEA_ID":35155,"compounds":"(S)-4,5-dihydroxypentane-2,3-dione = (2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one"}
{"X":36996,"RHEA_ID":55084,"compounds":"(3R)-hydroxypentanoyl-CoA + H2O = (3R)-hydroxypentanoate + CoA + H(+)"}
{"X":36997,"RHEA_ID":35157,"compounds":"(2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one => (S)-4,5-dihydroxypentane-2,3-dione"}
{"X":36998,"RHEA_ID":35158,"compounds":"(S)-4,5-dihydroxypentane-2,3-dione <=> (2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one"}
{"X":36999,"RHEA_ID":35159,"compounds":"(2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one + H2O = (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol"}
{"X":37000,"RHEA_ID":45105,"DIRECTION":"LR","MASTER_ID":45104,"metacyc":"RXN-16271","compounds":"6-demethylmitomycin A + S-adenosyl-L-methionine => mitomycin A + S-adenosyl-L-homocysteine"}
{"X":37001,"RHEA_ID":35161,"compounds":"(2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol => (2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one + H2O"}
{"X":37002,"RHEA_ID":35162,"compounds":"(2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one + H2O <=> (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol"}
{"X":37003,"RHEA_ID":35163,"compounds":"H(+)(out) + minocycline(in) = H(+)(in) + minocycline(out)"}
{"X":37004,"RHEA_ID":45109,"compounds":"(+)-alpha-tocopherol + O2 + reduced [NADPH--hemoprotein reductase] => 13-hydroxy-alpha-tocopherol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":37005,"RHEA_ID":35165,"compounds":"H(+)(in) + minocycline(out) => H(+)(out) + minocycline(in)"}
{"X":37006,"RHEA_ID":35166,"compounds":"H(+)(out) + minocycline(in) <=> H(+)(in) + minocycline(out)"}
{"X":37007,"RHEA_ID":35167,"compounds":"minocycline(in) = minocycline(out)"}
{"X":37008,"RHEA_ID":45113,"compounds":"gamma-tocopherol + H(+) + NADPH + O2 => 13-hydroxy-gamma-tocopherol + H2O + NADP(+)"}
{"X":37009,"RHEA_ID":35169,"compounds":"minocycline(out) => minocycline(in)"}
{"X":37010,"RHEA_ID":35170,"compounds":"minocycline(in) <=> minocycline(out)"}
{"X":37011,"RHEA_ID":35171,"compounds":"H(+)(out) + novobiocin(in) = H(+)(in) + novobiocin(out)"}
{"X":37012,"RHEA_ID":55100,"compounds":"3-oxopentanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxypentanoyl-[ACP] + NADP(+)"}
{"X":37013,"RHEA_ID":35173,"compounds":"H(+)(in) + novobiocin(out) => H(+)(out) + novobiocin(in)"}
{"X":37014,"RHEA_ID":35174,"compounds":"H(+)(out) + novobiocin(in) <=> H(+)(in) + novobiocin(out)"}
{"X":37015,"RHEA_ID":35175,"compounds":"novobiocin(in) = novobiocin(out)"}
{"X":37016,"RHEA_ID":55104,"compounds":"3-oxoheptanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyheptanoyl-[ACP] + NADP(+)"}
{"X":37017,"RHEA_ID":35177,"compounds":"novobiocin(out) => novobiocin(in)"}
{"X":37018,"RHEA_ID":35178,"compounds":"novobiocin(in) <=> novobiocin(out)"}
{"X":37019,"RHEA_ID":35179,"DIRECTION":"UN","MASTER_ID":35179,"ec":"2.3.1.221","compounds":"6 H(+) + hexanoyl-[ACP] + 7 malonyl-CoA = 7 CO2 + 7 CoA + 2 H2O + holo-[ACP] + noranthrone"}
{"X":37020,"RHEA_ID":55108,"compounds":"3-oxononanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxynonanoyl-[ACP] + NADP(+)"}
{"X":37021,"RHEA_ID":35181,"compounds":"7 CO2 + 7 CoA + 2 H2O + holo-[ACP] + noranthrone => 6 H(+) + hexanoyl-[ACP] + 7 malonyl-CoA"}
{"X":37022,"RHEA_ID":55110,"compounds":"(3R)-hydroxynonanoyl-[ACP] + NADP(+) => 3-oxononanoyl-[ACP] + H(+) + NADPH"}
{"X":37023,"RHEA_ID":35183,"compounds":"5-hydroxythiophene-2-carbonyl-CoA + H2O = 4-carboxy-2-thioxobutanoyl-CoA"}
{"X":37024,"RHEA_ID":45129,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)"}
{"X":37025,"RHEA_ID":35185,"compounds":"4-carboxy-2-thioxobutanoyl-CoA => 5-hydroxythiophene-2-carbonyl-CoA + H2O"}
{"X":37026,"RHEA_ID":35186,"compounds":"5-hydroxythiophene-2-carbonyl-CoA + H2O <=> 4-carboxy-2-thioxobutanoyl-CoA"}
{"X":37027,"RHEA_ID":35187,"compounds":"(Z)-3-aminoperacrylic acid + AH2 = (Z)-3-aminoacrylate + A + H(+) + H2O"}
{"X":37028,"RHEA_ID":55116,"compounds":"3-oxo-5-methylhexanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxy-5-methylhexanoyl-[ACP] + NADP(+)"}
{"X":37029,"RHEA_ID":35189,"compounds":"(Z)-3-aminoacrylate + A + H(+) + H2O => (Z)-3-aminoperacrylic acid + AH2"}
{"X":37030,"RHEA_ID":35190,"compounds":"(Z)-3-aminoperacrylic acid + AH2 <=> (Z)-3-aminoacrylate + A + H(+) + H2O"}
{"X":37031,"RHEA_ID":35191,"DIRECTION":"UN","MASTER_ID":35191,"ec":"1.13.12.20","compounds":"noranthrone + O2 = H2O + norsolorinic acid"}
{"X":37032,"RHEA_ID":35192,"DIRECTION":"LR","MASTER_ID":35191,"metacyc":"RXN-11624","compounds":"noranthrone + O2 => H2O + norsolorinic acid"}
{"X":37033,"RHEA_ID":35193,"compounds":"H2O + norsolorinic acid => noranthrone + O2"}
{"X":37034,"RHEA_ID":55122,"compounds":"(3R)-hydroxy-4-methylhexanoyl-[ACP] + NADP(+) => 3-oxo-4-methylhexanoyl-[ACP] + H(+) + NADPH"}
{"X":37035,"RHEA_ID":35195,"compounds":"L-quinate(in) = L-quinate(out)"}
{"X":37036,"RHEA_ID":45141,"compounds":"2,3-epoxyphylloquinone + 4-carboxy-L-glutamyl-[protein] + H(+) + H2O => CO2 + L-glutamyl-[protein] + O2 + phylloquinol"}
{"X":37037,"RHEA_ID":35197,"compounds":"L-quinate(out) => L-quinate(in)"}
{"X":37038,"RHEA_ID":55126,"compounds":"5-methylhexanoyl-[ACP] + NAD(+) => (2E)-5-methylhexenoyl-[ACP] + H(+) + NADH"}
{"X":37039,"RHEA_ID":35199,"compounds":"(S,S)-tartrate(out) = (S,S)-tartrate(in)"}
{"X":37040,"RHEA_ID":45145,"DIRECTION":"LR","MASTER_ID":45144,"metacyc":"RXN-12573","compounds":"3-(methylsulfanyl)acryloyl-CoA + 2 H2O => acetaldehyde + CO2 + CoA + methanethiol"}
{"X":37041,"RHEA_ID":35201,"compounds":"(S,S)-tartrate(in) => (S,S)-tartrate(out)"}
{"X":37042,"RHEA_ID":55130,"compounds":"(2E)-5-methylhexenoyl-[ACP] + H2O => (3R)-hydroxy-5-methylhexanoyl-[ACP]"}
{"X":37043,"RHEA_ID":35207,"DIRECTION":"UN","MASTER_ID":35207,"ec":"3.6.1.64","compounds":"H2O + IDP = H(+) + IMP + phosphate"}
{"X":37044,"RHEA_ID":45149,"DIRECTION":"LR","MASTER_ID":45148,"metacyc":"RXN-16010","compounds":"3-(methylsulfanyl)acryloyl-CoA + H2O => 3-hydroxy-3-(methylsulfanyl)propanoyl-CoA"}
{"X":37045,"RHEA_ID":35209,"compounds":"H(+) + IMP + phosphate => H2O + IDP"}
{"X":37046,"RHEA_ID":38556,"DIRECTION":"LR","MASTER_ID":38555,"metacyc":"RXN-12575","compounds":"an all-trans-retinyl ester + H2O => a fatty acid + all-trans-retinol + H(+)"}
{"X":37047,"RHEA_ID":35211,"DIRECTION":"UN","MASTER_ID":35211,"ec":"3.6.1.64","compounds":"dIDP + H2O = dIMP + H(+) + phosphate"}
{"X":37048,"RHEA_ID":45153,"DIRECTION":"LR","MASTER_ID":45152,"metacyc":"RXN-16011","compounds":"3-hydroxy-3-(methylsulfanyl)propanoyl-CoA => 3-oxopropanoyl-CoA + methanethiol"}
{"X":37049,"RHEA_ID":35213,"compounds":"dIMP + H(+) + phosphate => dIDP + H2O"}
{"X":37050,"RHEA_ID":38560,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + tetracosanoate => (R)-2-hydroxytetracosanoate + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":37051,"RHEA_ID":35215,"compounds":"H2O + XDP = H(+) + phosphate + XMP"}
{"X":37052,"RHEA_ID":45157,"DIRECTION":"LR","MASTER_ID":45156,"metacyc":"RXN-16012","compounds":"3-oxopropanoyl-CoA + H2O => 3-oxopropanoate + CoA + H(+)"}
{"X":37053,"RHEA_ID":35217,"compounds":"H(+) + phosphate + XMP => H2O + XDP"}
{"X":37054,"RHEA_ID":55142,"compounds":"AMP + D-alanyl-[D-alanyl-carrier protein] + H(+) => D-alanyl-5'-AMP + holo-[D-alanyl-carrier protein]"}
{"X":37055,"RHEA_ID":35219,"compounds":"8-oxo-dADP + H2O = 8-oxo-dAMP + H(+) + phosphate"}
{"X":37056,"RHEA_ID":35220,"compounds":"8-oxo-dADP + H2O => 8-oxo-dAMP + H(+) + phosphate"}
{"X":37057,"RHEA_ID":45162,"compounds":"acetaldehyde + CO2 => 3-oxopropanoate + H(+)"}
{"X":37058,"RHEA_ID":35222,"compounds":"8-oxo-dADP + H2O <=> 8-oxo-dAMP + H(+) + phosphate"}
{"X":37059,"RHEA_ID":35223,"compounds":"2-oxo-dADP + H2O = 2-hydroxy-dAMP + H(+) + phosphate"}
{"X":37060,"RHEA_ID":35224,"compounds":"2-oxo-dADP + H2O => 2-hydroxy-dAMP + H(+) + phosphate"}
{"X":37061,"RHEA_ID":45166,"compounds":"2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O"}
{"X":37062,"RHEA_ID":35226,"compounds":"2-oxo-dADP + H2O <=> 2-hydroxy-dAMP + H(+) + phosphate"}
{"X":37063,"RHEA_ID":45168,"DIRECTION":"UN","MASTER_ID":45168,"ec":"2.3.1.248","compounds":"2 sinapoyl-CoA + spermidine = 2 CoA + 2 H(+) + N(1),N(8)-bis(sinapoyl)-spermidine"}
{"X":37064,"RHEA_ID":35228,"compounds":"H(+)(out) + rifampicin(in) => H(+)(in) + rifampicin(out)"}
{"X":37065,"RHEA_ID":35229,"compounds":"H(+)(in) + rifampicin(out) => H(+)(out) + rifampicin(in)"}
{"X":37066,"RHEA_ID":35230,"compounds":"H(+)(out) + rifampicin(in) <=> H(+)(in) + rifampicin(out)"}
{"X":37067,"RHEA_ID":45172,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":37068,"RHEA_ID":35232,"compounds":"rifampicin(in) => rifampicin(out)"}
{"X":37069,"RHEA_ID":45174,"compounds":"2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":37070,"RHEA_ID":35234,"compounds":"rifampicin(in) <=> rifampicin(out)"}
{"X":37071,"RHEA_ID":45176,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":37072,"RHEA_ID":35236,"compounds":"H(+)(out) + tetracycline(in) => H(+)(in) + tetracycline(out)"}
{"X":37073,"RHEA_ID":45178,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":37074,"RHEA_ID":35238,"compounds":"H(+)(out) + tetracycline(in) <=> H(+)(in) + tetracycline(out)"}
{"X":37075,"RHEA_ID":35239,"compounds":"tetracycline(in) = tetracycline(out)"}
{"X":37076,"RHEA_ID":35240,"compounds":"tetracycline(in) => tetracycline(out)"}
{"X":37077,"RHEA_ID":35241,"compounds":"tetracycline(out) => tetracycline(in)"}
{"X":37078,"RHEA_ID":38588,"compounds":"UDP-alpha-D-glucose + vancomycin aglycone => devancoaminyl-vancomycin + UDP"}
{"X":37079,"RHEA_ID":35243,"compounds":"ADP + H(+) + thiamine diphosphate = adenosine thiamine triphosphate + phosphate"}
{"X":37080,"RHEA_ID":35244,"compounds":"ADP + H(+) + thiamine diphosphate => adenosine thiamine triphosphate + phosphate"}
{"X":37081,"RHEA_ID":35245,"compounds":"adenosine thiamine triphosphate + phosphate => ADP + H(+) + thiamine diphosphate"}
{"X":37082,"RHEA_ID":55170,"compounds":"[TtuB sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate => [TtuB sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+)"}
{"X":37083,"RHEA_ID":35247,"compounds":"alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA(in) + ATP + H2O = ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA(out) + H(+) + phosphate"}
{"X":37084,"RHEA_ID":35248,"compounds":"alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA(in) + ATP + H2O => ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA(out) + H(+) + phosphate"}
{"X":37085,"RHEA_ID":35249,"compounds":"ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA(out) + H(+) + phosphate => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA(in) + ATP + H2O"}
{"X":37086,"RHEA_ID":55174,"compounds":"2-hydroxyhexanoyl-CoA + CO2 + succinate => 2-oxoglutarate + hexanoyl-CoA + O2"}
{"X":37087,"RHEA_ID":35251,"compounds":"alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(in) + ATP + H2O = ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(out) + H(+) + phosphate"}
{"X":37088,"RHEA_ID":35252,"compounds":"alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(in) + ATP + H2O => ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(out) + H(+) + phosphate"}
{"X":37089,"RHEA_ID":35253,"compounds":"ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(out) + H(+) + phosphate => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(in) + ATP + H2O"}
{"X":37090,"RHEA_ID":45195,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a 1-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine"}
{"X":37091,"RHEA_ID":35255,"compounds":"ATP + H2O + lipid A-core(in) = ADP + H(+) + lipid A-core(out) + phosphate"}
{"X":37092,"RHEA_ID":35256,"compounds":"ATP + H2O + lipid A-core(in) => ADP + H(+) + lipid A-core(out) + phosphate"}
{"X":37093,"RHEA_ID":35257,"compounds":"ADP + H(+) + lipid A-core(out) + phosphate => ATP + H2O + lipid A-core(in)"}
{"X":37094,"RHEA_ID":55182,"compounds":"2-hydroxy-3-methylnonanoyl-CoA + CO2 + succinate => 2-oxoglutarate + 3-methylnonanoyl-CoA + O2"}
{"X":37095,"RHEA_ID":35259,"compounds":"7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(in) + ATP + H2O = 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(out) + ADP + H(+) + phosphate"}
{"X":37096,"RHEA_ID":35260,"compounds":"7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(in) + ATP + H2O => 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(out) + ADP + H(+) + phosphate"}
{"X":37097,"RHEA_ID":35261,"compounds":"7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(out) + ADP + H(+) + phosphate => 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(in) + ATP + H2O"}
{"X":37098,"RHEA_ID":55186,"compounds":"2-hydroxy-3-methylundecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + 3-methylundecanoyl-CoA + O2"}
{"X":37099,"RHEA_ID":35263,"compounds":"a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + a fatty acid + H(+) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O"}
{"X":37100,"RHEA_ID":35264,"compounds":"a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O"}
{"X":37101,"RHEA_ID":35265,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + a fatty acid + H(+)"}
{"X":37102,"RHEA_ID":35267,"compounds":"ethanol(in) = ethanol(out)"}
{"X":37103,"RHEA_ID":35268,"compounds":"ethanol(in) => ethanol(out)"}
{"X":37104,"RHEA_ID":35269,"compounds":"ethanol(out) => ethanol(in)"}
{"X":37105,"RHEA_ID":55194,"compounds":"2-hydroxy-3-methyldodecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + 3-methyldodecanoyl-CoA + O2"}
{"X":37106,"RHEA_ID":35271,"compounds":"a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}
{"X":37107,"RHEA_ID":35272,"compounds":"a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}
{"X":37108,"RHEA_ID":35273,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + an acyl-CoA"}
{"X":37109,"RHEA_ID":55198,"compounds":"formyl-CoA + heptadecanal => 2-hydroxyoctadecanoyl-CoA"}
{"X":37110,"RHEA_ID":45216,"DIRECTION":"UN","MASTER_ID":45216,"ec":"2.1.1.247","compounds":"[methyl-Co(III) dimethylamine-specific corrinoid protein] + coenzyme M = [Co(I) dimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M"}
{"X":37111,"RHEA_ID":35276,"compounds":"3-hydroxyoctadecanoyl-CoA + NAD(+) => 3-oxooctadecanoyl-CoA + H(+) + NADH"}
{"X":37112,"RHEA_ID":35277,"compounds":"3-oxooctadecanoyl-CoA + H(+) + NADH => 3-hydroxyoctadecanoyl-CoA + NAD(+)"}
{"X":37113,"RHEA_ID":45219,"compounds":"[methyl-Co(III) dimethylamine-specific corrinoid protein] + coenzyme M <=> [Co(I) dimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M"}
{"X":37114,"RHEA_ID":35279,"compounds":"acetyl-CoA + hexadecanoyl-CoA = 3-oxooctadecanoyl-CoA + CoA"}
{"X":37115,"RHEA_ID":45221,"DIRECTION":"LR","MASTER_ID":45220,"metacyc":"RXN-8103","compounds":"[methyl-Co(III) trimethylamine-specific corrinoid protein] + coenzyme M => [Co(I) trimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M"}
{"X":37116,"RHEA_ID":35281,"compounds":"3-oxooctadecanoyl-CoA + CoA => acetyl-CoA + hexadecanoyl-CoA"}
{"X":37117,"RHEA_ID":35282,"compounds":"acetyl-CoA + hexadecanoyl-CoA <=> 3-oxooctadecanoyl-CoA + CoA"}
{"X":37118,"RHEA_ID":35283,"compounds":"(9Z)-octadecenoyl-CoA = (2E)-octadecenoyl-CoA"}
{"X":37119,"RHEA_ID":45225,"compounds":"(3E,5Z,8Z,11Z,14Z)-eicosapentaenoyl-CoA => (2E,4E,8Z,11Z,14Z)-eicosapentaenoyl-CoA"}
{"X":37120,"RHEA_ID":35285,"compounds":"(2E)-octadecenoyl-CoA => (9Z)-octadecenoyl-CoA"}
{"X":37121,"RHEA_ID":45227,"compounds":"(3E,5Z,8Z,11Z,14Z)-eicosapentaenoyl-CoA <=> (2E,4E,8Z,11Z,14Z)-eicosapentaenoyl-CoA"}
{"X":37122,"RHEA_ID":35287,"compounds":"chloramphenicol(in) = chloramphenicol(out)"}
{"X":37123,"RHEA_ID":35288,"compounds":"chloramphenicol(in) => chloramphenicol(out)"}
{"X":37124,"RHEA_ID":45230,"compounds":"a 4-saturated (2E)-enoyl-CoA => a (3E)-enoyl-CoA"}
{"X":37125,"RHEA_ID":35290,"compounds":"chloramphenicol(in) <=> chloramphenicol(out)"}
{"X":37126,"RHEA_ID":35291,"compounds":"11-methyldodecanoyl-CoA + H(+) + malonyl-CoA = 3-oxoisopentadecanoyl-CoA + CO2 + CoA"}
{"X":37127,"RHEA_ID":35292,"compounds":"11-methyldodecanoyl-CoA + H(+) + malonyl-CoA => 3-oxoisopentadecanoyl-CoA + CO2 + CoA"}
{"X":37128,"RHEA_ID":45234,"compounds":"a 4,5-saturated-(2E)-enoyl-CoA + NADP(+) => a (2E,4Z)-dienoyl-CoA + H(+) + NADPH"}
{"X":37129,"RHEA_ID":45235,"compounds":"a (2E,4Z)-dienoyl-CoA + H(+) + NADPH <=> a 4,5-saturated-(2E)-enoyl-CoA + NADP(+)"}
{"X":37130,"RHEA_ID":35295,"compounds":"adenylyl-molybdopterin + H(+) + tungstate = AMP + H2O + W-molybdopterin cofactor"}
{"X":37131,"RHEA_ID":35296,"compounds":"adenylyl-molybdopterin + H(+) + tungstate => AMP + H2O + W-molybdopterin cofactor"}
{"X":37132,"RHEA_ID":45238,"compounds":"(25R)-3beta-hydroxy-5-cholestenoate + H2O + 2 oxidized [adrenodoxin] => (25R)-3beta-hydroxy-5-cholesten-26-al + H(+) + O2 + 2 reduced [adrenodoxin]"}
{"X":37133,"RHEA_ID":45239,"compounds":"(25R)-3beta-hydroxy-5-cholesten-26-al + H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta-hydroxy-5-cholestenoate + H2O + 2 oxidized [adrenodoxin]"}
{"X":37134,"RHEA_ID":35299,"compounds":"3-hydroxyoctadecanoyl-CoA + NADP(+) = 3-oxooctadecanoyl-CoA + H(+) + NADPH"}
{"X":37135,"RHEA_ID":35300,"compounds":"3-hydroxyoctadecanoyl-CoA + NADP(+) => 3-oxooctadecanoyl-CoA + H(+) + NADPH"}
{"X":37136,"RHEA_ID":45242,"compounds":"a (2E,4E)-(5,6-saturated)-dienoyl-CoA => a (3E,5Z)-dienoyl-CoA"}
{"X":37137,"RHEA_ID":45243,"compounds":"a (3E,5Z)-dienoyl-CoA <=> a (2E,4E)-(5,6-saturated)-dienoyl-CoA"}
{"X":37138,"RHEA_ID":35303,"compounds":"3-hydroxyisopentadecanoyl-CoA + NADP(+) = 3-oxoisopentadecanoyl-CoA + H(+) + NADPH"}
{"X":37139,"RHEA_ID":35304,"compounds":"3-hydroxyisopentadecanoyl-CoA + NADP(+) => 3-oxoisopentadecanoyl-CoA + H(+) + NADPH"}
{"X":37140,"RHEA_ID":45246,"compounds":"(2E,4E)-octadienoyl-CoA => (3E,5Z)-octadienoyl-CoA"}
{"X":37141,"RHEA_ID":45247,"compounds":"(3E,5Z)-octadienoyl-CoA <=> (2E,4E)-octadienoyl-CoA"}
{"X":37142,"RHEA_ID":35307,"DIRECTION":"UN","MASTER_ID":35307,"ec":"1.14.13.172","compounds":"H(+) + NADH + O2 + salicylate = 2,5-dihydroxybenzoate + H2O + NAD(+)"}
{"X":37143,"RHEA_ID":35308,"DIRECTION":"LR","MASTER_ID":35307,"metacyc":"RXN-10446","compounds":"H(+) + NADH + O2 + salicylate => 2,5-dihydroxybenzoate + H2O + NAD(+)"}
{"X":37144,"RHEA_ID":45250,"compounds":"butanoate(in) => butanoate(out)"}
{"X":37145,"RHEA_ID":55234,"compounds":"3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate + 2 [Fe(III)-cytochrome b561] + H2O => 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 [Fe(II)-cytochrome b5] + H(+) + O2"}
{"X":37146,"RHEA_ID":35311,"compounds":"3-hydroxyisoheptadecanoyl-CoA + NADP(+) = 3-oxoisoheptadecanoyl-CoA + H(+) + NADPH"}
{"X":37147,"RHEA_ID":35312,"compounds":"3-hydroxyisoheptadecanoyl-CoA + NADP(+) => 3-oxoisoheptadecanoyl-CoA + H(+) + NADPH"}
{"X":37148,"RHEA_ID":35313,"compounds":"3-oxoisoheptadecanoyl-CoA + H(+) + NADPH => 3-hydroxyisoheptadecanoyl-CoA + NADP(+)"}
{"X":37149,"RHEA_ID":35314,"compounds":"3-hydroxyisoheptadecanoyl-CoA + NADP(+) <=> 3-oxoisoheptadecanoyl-CoA + H(+) + NADPH"}
{"X":37150,"RHEA_ID":35315,"compounds":"H(+) + hexadecanoyl-CoA + malonyl-CoA = 3-oxooctadecanoyl-CoA + CO2 + CoA"}
{"X":37151,"RHEA_ID":35316,"DIRECTION":"LR","MASTER_ID":35315,"reactome":"R-HSA-548814.1","compounds":"H(+) + hexadecanoyl-CoA + malonyl-CoA => 3-oxooctadecanoyl-CoA + CO2 + CoA"}
{"X":37152,"RHEA_ID":45258,"DIRECTION":"RL","MASTER_ID":45256,"reactome":"R-HSA-434381.1","compounds":"hexadecanoate(in) => hexadecanoate(out)"}
{"X":37153,"RHEA_ID":45259,"compounds":"hexadecanoate(out) <=> hexadecanoate(in)"}
{"X":37154,"RHEA_ID":35319,"compounds":"H(+) + malonyl-CoA + octadecanoyl-CoA = 3-oxoeicosanoyl-CoA + CO2 + CoA"}
{"X":37155,"RHEA_ID":35320,"compounds":"H(+) + malonyl-CoA + octadecanoyl-CoA => 3-oxoeicosanoyl-CoA + CO2 + CoA"}
{"X":37156,"RHEA_ID":45262,"compounds":"tetracosanoate(in) => tetracosanoate(out)"}
{"X":37157,"RHEA_ID":45263,"compounds":"tetracosanoate(out) <=> tetracosanoate(in)"}
{"X":37158,"RHEA_ID":35323,"DIRECTION":"UN","MASTER_ID":35323,"ec":"1.17.1.8","compounds":"(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH"}
{"X":37159,"RHEA_ID":35324,"compounds":"(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) => (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH"}
{"X":37160,"RHEA_ID":45266,"compounds":"(9Z,12Z)-octadecadienoate(in) => (9Z,12Z)-octadecadienoate(out)"}
{"X":37161,"RHEA_ID":55250,"compounds":"2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":37162,"RHEA_ID":35327,"compounds":"eicosanoyl-CoA + H(+) + malonyl-CoA = 3-oxodocosanoyl-CoA + CO2 + CoA"}
{"X":37163,"RHEA_ID":35328,"DIRECTION":"LR","MASTER_ID":35327,"reactome":"R-HSA-548815.2","compounds":"eicosanoyl-CoA + H(+) + malonyl-CoA => 3-oxodocosanoyl-CoA + CO2 + CoA"}
{"X":37164,"RHEA_ID":35329,"compounds":"3-oxodocosanoyl-CoA + CO2 + CoA => eicosanoyl-CoA + H(+) + malonyl-CoA"}
{"X":37165,"RHEA_ID":35330,"compounds":"eicosanoyl-CoA + H(+) + malonyl-CoA <=> 3-oxodocosanoyl-CoA + CO2 + CoA"}
{"X":37166,"RHEA_ID":35331,"DIRECTION":"UN","MASTER_ID":35331,"ec":"1.17.1.8","compounds":"(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH"}
{"X":37167,"RHEA_ID":35332,"compounds":"(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) => (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH"}
{"X":37168,"RHEA_ID":45274,"compounds":"12-hydroxy-(9Z)-octadecenoate + phosphate => 12-phosphooxy-(9Z)-octadecenoate + H2O"}
{"X":37169,"RHEA_ID":55258,"compounds":"2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":37170,"RHEA_ID":35335,"compounds":"H(+) + isopentadecanoyl-CoA + malonyl-CoA = 3-oxoisoheptadecanoyl-CoA + CO2 + CoA"}
{"X":37171,"RHEA_ID":35336,"compounds":"H(+) + isopentadecanoyl-CoA + malonyl-CoA => 3-oxoisoheptadecanoyl-CoA + CO2 + CoA"}
{"X":37172,"RHEA_ID":35337,"compounds":"3-oxoisoheptadecanoyl-CoA + CO2 + CoA => H(+) + isopentadecanoyl-CoA + malonyl-CoA"}
{"X":37173,"RHEA_ID":45279,"compounds":"12-phosphooxy-(9E)-octadecenoate + H2O <=> 12-hydroxy-(9E)-octadecenoate + phosphate"}
{"X":37174,"RHEA_ID":35339,"compounds":"3-hydroxyicosanoyl-CoA + NADP(+) = 3-oxoeicosanoyl-CoA + H(+) + NADPH"}
{"X":37175,"RHEA_ID":35340,"compounds":"3-hydroxyicosanoyl-CoA + NADP(+) => 3-oxoeicosanoyl-CoA + H(+) + NADPH"}
{"X":37176,"RHEA_ID":35341,"compounds":"3-oxoeicosanoyl-CoA + H(+) + NADPH => 3-hydroxyicosanoyl-CoA + NADP(+)"}
{"X":37177,"RHEA_ID":45283,"compounds":"12-(phosphooxy)octadecanoate + H2O <=> 12-hydroxyoctadecanoate + phosphate"}
{"X":37178,"RHEA_ID":35343,"compounds":"3-hydroxydocosanoyl-CoA + NADP(+) = 3-oxodocosanoyl-CoA + H(+) + NADPH"}
{"X":37179,"RHEA_ID":35344,"compounds":"3-hydroxydocosanoyl-CoA + NADP(+) => 3-oxodocosanoyl-CoA + H(+) + NADPH"}
{"X":37180,"RHEA_ID":35345,"compounds":"3-oxodocosanoyl-CoA + H(+) + NADPH => 3-hydroxydocosanoyl-CoA + NADP(+)"}
{"X":37181,"RHEA_ID":45287,"compounds":"eicosanoyl-CoA + sphing-4-enine <=> CoA + H(+) + N-eicosanoyl-sphing-4-enine"}
{"X":37182,"RHEA_ID":35347,"compounds":"3-hydroxyoctadecanoyl-CoA = (2E)-octadecenoyl-CoA + H2O"}
{"X":37183,"RHEA_ID":35348,"compounds":"3-hydroxyoctadecanoyl-CoA => (2E)-octadecenoyl-CoA + H2O"}
{"X":37184,"RHEA_ID":45290,"compounds":"2-glyceryl-prostaglandin G2 => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 2 O2"}
{"X":37185,"RHEA_ID":45291,"compounds":"2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 2 O2 <=> 2-glyceryl-prostaglandin G2"}
{"X":37186,"RHEA_ID":35351,"compounds":"NADP(+) + octadecanoyl-CoA = (2E)-octadecenoyl-CoA + H(+) + NADPH"}
{"X":37187,"RHEA_ID":35352,"compounds":"NADP(+) + octadecanoyl-CoA => (2E)-octadecenoyl-CoA + H(+) + NADPH"}
{"X":37188,"RHEA_ID":45294,"compounds":"2-glyceryl-prostaglandin H2 + A + H2O => 2-glyceryl-prostaglandin G2 + AH2"}
{"X":37189,"RHEA_ID":45295,"compounds":"2-glyceryl-prostaglandin G2 + AH2 <=> 2-glyceryl-prostaglandin H2 + A + H2O"}
{"X":37190,"RHEA_ID":35355,"compounds":"3-hydroxyisopentadecanoyl-CoA = (2E)-13-methyltetradecenoyl-CoA + H2O"}
{"X":37191,"RHEA_ID":35356,"compounds":"3-hydroxyisopentadecanoyl-CoA => (2E)-13-methyltetradecenoyl-CoA + H2O"}
{"X":37192,"RHEA_ID":45298,"compounds":"a sphingoid base + H(+) + phosphocholine => H2O + sphingosylphosphocholine"}
{"X":37193,"RHEA_ID":45299,"compounds":"H2O + sphingosylphosphocholine <=> a sphingoid base + H(+) + phosphocholine"}
{"X":37194,"RHEA_ID":35359,"compounds":"3-hydroxyisoheptadecanoyl-CoA = (2E)-15-methylhexadecenoyl-CoA + H2O"}
{"X":37195,"RHEA_ID":35360,"compounds":"3-hydroxyisoheptadecanoyl-CoA => (2E)-15-methylhexadecenoyl-CoA + H2O"}
{"X":37196,"RHEA_ID":45302,"compounds":"H(+) + N-acyl-sphingoid base + phosphocholine => an N-(acyl)-sphingosylphosphocholine + H2O"}
{"X":37197,"RHEA_ID":45303,"compounds":"an N-(acyl)-sphingosylphosphocholine + H2O <=> H(+) + N-acyl-sphingoid base + phosphocholine"}
{"X":37198,"RHEA_ID":35363,"compounds":"(2E)-13-methyltetradecenoyl-CoA + H(+) + NADPH = isopentadecanoyl-CoA + NADP(+)"}
{"X":37199,"RHEA_ID":35364,"compounds":"(2E)-13-methyltetradecenoyl-CoA + H(+) + NADPH => isopentadecanoyl-CoA + NADP(+)"}
{"X":37200,"RHEA_ID":45306,"compounds":"1,2-dihexadecanoyl-sn-glycerol + H(+) + phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":37201,"RHEA_ID":45307,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1,2-dihexadecanoyl-sn-glycerol + H(+) + phosphocholine"}
{"X":37202,"RHEA_ID":35367,"compounds":"(2E)-15-methylhexadecenoyl-CoA + H(+) + NADPH = isoheptadecanoyl-coA + NADP(+)"}
{"X":37203,"RHEA_ID":35368,"compounds":"(2E)-15-methylhexadecenoyl-CoA + H(+) + NADPH => isoheptadecanoyl-coA + NADP(+)"}
{"X":37204,"RHEA_ID":45310,"compounds":"11beta-prostaglandin F2-ethanolamide + NADP(+) => H(+) + NADPH + prostaglandin D2-ethanolamide"}
{"X":37205,"RHEA_ID":45311,"compounds":"H(+) + NADPH + prostaglandin D2-ethanolamide <=> 11beta-prostaglandin F2-ethanolamide + NADP(+)"}
{"X":37206,"RHEA_ID":35371,"DIRECTION":"UN","MASTER_ID":35371,"ec":"2.4.2.43","compounds":"2 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A = (beta-L-Ara4N)2-(Kdo)2-lipid A + 2 di-trans,octa-cis-undecaprenyl phosphate"}
{"X":37207,"RHEA_ID":35372,"DIRECTION":"LR","MASTER_ID":35371,"ecocyc":"RXN0-2001","metacyc":"RXN0-2001","compounds":"2 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A => (beta-L-Ara4N)2-(Kdo)2-lipid A + 2 di-trans,octa-cis-undecaprenyl phosphate"}
{"X":37208,"RHEA_ID":45314,"DIRECTION":"RL","MASTER_ID":45312,"reactome":"R-HSA-2161549.2","compounds":"H(+) + NADPH + prostaglandin H2 => NADP(+) + prostaglandin F2alpha"}
{"X":37209,"RHEA_ID":35374,"compounds":"2 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A <=> (beta-L-Ara4N)2-(Kdo)2-lipid A + 2 di-trans,octa-cis-undecaprenyl phosphate"}
{"X":37210,"RHEA_ID":45316,"compounds":"H(+) + NADPH + prostaglandin D2 = 11beta-prostaglandin F2 + NADP(+)"}
{"X":37211,"RHEA_ID":35376,"compounds":"(beta-L-Ara4N)2-(Kdo)2-lipid A(in) + ATP + H2O => (beta-L-Ara4N)2-(Kdo)2-lipid A(out) + ADP + H(+) + phosphate"}
{"X":37212,"RHEA_ID":45318,"compounds":"11beta-prostaglandin F2 + NADP(+) => H(+) + NADPH + prostaglandin D2"}
{"X":37213,"RHEA_ID":35378,"compounds":"(beta-L-Ara4N)2-(Kdo)2-lipid A(in) + ATP + H2O <=> (beta-L-Ara4N)2-(Kdo)2-lipid A(out) + ADP + H(+) + phosphate"}
{"X":37214,"RHEA_ID":35379,"compounds":"(6Z,9Z,12Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA = (8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA"}
{"X":37215,"RHEA_ID":35380,"compounds":"(6Z,9Z,12Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA => (8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA"}
{"X":37216,"RHEA_ID":45322,"compounds":"H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine + phosphocholine => H2O + N-(15Z-tetracosenoyl)sphing-4-enine-1-phosphocholine"}
{"X":37217,"RHEA_ID":35382,"compounds":"(6Z,9Z,12Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA <=> (8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA"}
{"X":37218,"RHEA_ID":35383,"compounds":"precorrin-6B + S-adenosyl-L-methionine = CO2 + H(+) + precorrin-7 + S-adenosyl-L-homocysteine"}
{"X":37219,"RHEA_ID":35384,"DIRECTION":"LR","MASTER_ID":35383,"metacyc":"RXN-13824","compounds":"precorrin-6B + S-adenosyl-L-methionine => CO2 + H(+) + precorrin-7 + S-adenosyl-L-homocysteine"}
{"X":37220,"RHEA_ID":45326,"compounds":"H(+) + N-(tetracosanoyl)-sphing-4-enine + phosphocholine => H2O + N-(tetracosanoyl)-sphing-4-enine-1-phosphocholine"}
{"X":37221,"RHEA_ID":35386,"compounds":"precorrin-6B + S-adenosyl-L-methionine <=> CO2 + H(+) + precorrin-7 + S-adenosyl-L-homocysteine"}
{"X":37222,"RHEA_ID":45328,"DIRECTION":"UN","MASTER_ID":45328,"ec":"5.1.99.8","compounds":"7,8-dihydroneopterin = 7,8-dihydromonapterin"}
{"X":37223,"RHEA_ID":35388,"DIRECTION":"LR","MASTER_ID":35387,"metacyc":"RXN-13826","compounds":"precorrin-7 + S-adenosyl-L-methionine => 2 H(+) + precorrin-8X + S-adenosyl-L-homocysteine"}
{"X":37224,"RHEA_ID":45330,"compounds":"7,8-dihydromonapterin => 7,8-dihydroneopterin"}
{"X":37225,"RHEA_ID":35390,"compounds":"precorrin-7 + S-adenosyl-L-methionine <=> 2 H(+) + precorrin-8X + S-adenosyl-L-homocysteine"}
{"X":37226,"RHEA_ID":45332,"DIRECTION":"UN","MASTER_ID":45332,"ec":"1.13.11.81","compounds":"7,8-dihydroneopterin + O2 = 7,8-dihydroxanthopterin + formate + glycolaldehyde + H(+)"}
{"X":37227,"RHEA_ID":35392,"compounds":"(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + H(+) + malonyl-CoA => (8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + CO2 + CoA"}
{"X":37228,"RHEA_ID":45334,"compounds":"7,8-dihydroxanthopterin + formate + glycolaldehyde + H(+) => 7,8-dihydroneopterin + O2"}
{"X":37229,"RHEA_ID":35394,"compounds":"(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + H(+) + malonyl-CoA <=> (8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + CO2 + CoA"}
{"X":37230,"RHEA_ID":45336,"DIRECTION":"UN","MASTER_ID":45336,"ec":"2.3.1.250","metacyc":"RXN-16481","compounds":"(9Z)-hexadecenoyl-CoA + [Wnt protein]-L-serine = [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + CoA"}
{"X":37231,"RHEA_ID":35400,"DIRECTION":"LR","MASTER_ID":35399,"metacyc":"RXN-13962","compounds":"1-O-(trans-4-coumaroyl)-beta-D-glucose + cyanidin 3-O-(6-O-glucosyl-2-O-xylosylgalactoside) betaine => beta-D-glucose + cyanidin 3-O-[6-O-(6-O-4-hydroxycinnamoyl-beta-D-glucosyl)-2-O-beta-D-xylosyl-beta-D-galactoside] + H(+)"}
{"X":37232,"RHEA_ID":45338,"compounds":"[Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + CoA => (9Z)-hexadecenoyl-CoA + [Wnt protein]-L-serine"}
{"X":37233,"RHEA_ID":45340,"DIRECTION":"UN","MASTER_ID":45340,"ec":"3.1.1.98","compounds":"[Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + H2O = (9Z)-hexadecenoate + [Wnt protein]-L-serine + H(+)"}
{"X":37234,"RHEA_ID":35404,"compounds":"(3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol + NADP(+) => (3R)-vestitone + H(+) + NADPH"}
{"X":37235,"RHEA_ID":45342,"compounds":"(9Z)-hexadecenoate + [Wnt protein]-L-serine + H(+) => [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + H2O"}
{"X":37236,"RHEA_ID":45344,"compounds":"globoside NOR1 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = globoside NORint (d18:1(4E)) + H(+) + UDP"}
{"X":37237,"RHEA_ID":35408,"compounds":"H2O + medicarpin => 4'-methoxyisoflavan-2',4,7-triol"}
{"X":37238,"RHEA_ID":45346,"compounds":"globoside NORint (d18:1(4E)) + H(+) + UDP => globoside NOR1 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine"}
{"X":37239,"RHEA_ID":35410,"compounds":"H2O + medicarpin <=> 4'-methoxyisoflavan-2',4,7-triol"}
{"X":37240,"RHEA_ID":35411,"DIRECTION":"UN","MASTER_ID":35411,"ec":"2.3.1.215","compounds":"(E)-4-coumaroyl-CoA + an anthocyanidin 3-O-beta-D-glucoside = an anthocyanidin 3-O-[6-O-(4-hydroxycinnamoyl)-beta-D--glucoside] + CoA + H(+)"}
{"X":37241,"RHEA_ID":35412,"compounds":"(E)-4-coumaroyl-CoA + an anthocyanidin 3-O-beta-D-glucoside => an anthocyanidin 3-O-[6-O-(4-hydroxycinnamoyl)-beta-D--glucoside] + CoA + H(+)"}
{"X":37242,"RHEA_ID":45350,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + sphing-4-enine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphing-4-enine"}
{"X":37243,"RHEA_ID":45351,"compounds":"H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphing-4-enine <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + sphing-4-enine"}
{"X":37244,"RHEA_ID":45352,"compounds":"9,10-epoxyoctadecanoate + H2O = 9,10-dihydroxyoctadecanoate"}
{"X":37245,"RHEA_ID":35416,"DIRECTION":"LR","MASTER_ID":35415,"metacyc":"RXN-13963","compounds":"an anthocyanidin 3-O-beta-D-sambubioside + UDP-alpha-D-glucose => an anthocyanidin 5-O-beta-D-glucoside 3-O-beta-D-sambubioside + H(+) + UDP"}
{"X":37246,"RHEA_ID":45354,"compounds":"9,10-dihydroxyoctadecanoate => 9,10-epoxyoctadecanoate + H2O"}
{"X":37247,"RHEA_ID":45355,"compounds":"9,10-epoxyoctadecanoate + H2O <=> 9,10-dihydroxyoctadecanoate"}
{"X":37248,"RHEA_ID":45356,"compounds":"H2O + N-(11Z-eicosenoyl)-sphing-4-enine = (11Z)-eicosenoate + sphing-4-enine"}
{"X":37249,"RHEA_ID":35420,"DIRECTION":"LR","MASTER_ID":35419,"metacyc":"RXN-13964","compounds":"an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose => an anthocyanidin 3-O-sophoroside + 2 H(+) + UDP"}
{"X":37250,"RHEA_ID":45358,"compounds":"(11Z)-eicosenoate + sphing-4-enine => H2O + N-(11Z-eicosenoyl)-sphing-4-enine"}
{"X":37251,"RHEA_ID":45359,"compounds":"H2O + N-(11Z-eicosenoyl)-sphing-4-enine <=> (11Z)-eicosenoate + sphing-4-enine"}
{"X":37252,"RHEA_ID":45360,"compounds":"H2O + N-(11Z-eicosenoyl)-sphinganine = (11Z)-eicosenoate + sphinganine"}
{"X":37253,"RHEA_ID":35424,"DIRECTION":"LR","MASTER_ID":35423,"metacyc":"RXN-13966","compounds":"an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose => an anthocyanidin 3,5-di-O-beta-D-glucoside + 2 H(+) + UDP"}
{"X":37254,"RHEA_ID":45362,"compounds":"(11Z)-eicosenoate + sphinganine => H2O + N-(11Z-eicosenoyl)-sphinganine"}
{"X":37255,"RHEA_ID":45363,"compounds":"H2O + N-(11Z-eicosenoyl)-sphinganine <=> (11Z)-eicosenoate + sphinganine"}
{"X":37256,"RHEA_ID":35427,"DIRECTION":"UN","MASTER_ID":35427,"ec":"2.4.1.299","compounds":"1-O-(trans-sinapoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside = cyanidin 3,5-di-O-beta-D-glucoside + trans-sinapate"}
{"X":37257,"RHEA_ID":45365,"compounds":"H2O + N-(11Z-eicosenoyl)-4-hydroxysphinganine => (11Z)-eicosenoate + 4-hydroxysphinganine"}
{"X":37258,"RHEA_ID":45366,"compounds":"(11Z)-eicosenoate + 4-hydroxysphinganine => H2O + N-(11Z-eicosenoyl)-4-hydroxysphinganine"}
{"X":37259,"RHEA_ID":45367,"compounds":"H2O + N-(11Z-eicosenoyl)-4-hydroxysphinganine <=> (11Z)-eicosenoate + 4-hydroxysphinganine"}
{"X":37260,"RHEA_ID":35431,"DIRECTION":"UN","MASTER_ID":35431,"ec":"2.4.1.300","compounds":"1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside = 4-hydroxy-3-methoxybenzoate + cyanidin 3,7-di-O-beta-D-glucoside"}
{"X":37261,"RHEA_ID":45369,"compounds":"H2O + N-(9Z-octadecenoyl)-4-hydroxysphinganine => (9Z)-octadecenoate + 4-hydroxysphinganine"}
{"X":37262,"RHEA_ID":45370,"compounds":"(9Z)-octadecenoate + 4-hydroxysphinganine => H2O + N-(9Z-octadecenoyl)-4-hydroxysphinganine"}
{"X":37263,"RHEA_ID":45371,"compounds":"H2O + N-(9Z-octadecenoyl)-4-hydroxysphinganine <=> (9Z)-octadecenoate + 4-hydroxysphinganine"}
{"X":37264,"RHEA_ID":35435,"DIRECTION":"UN","MASTER_ID":35435,"ec":"2.4.2.50","compounds":"cyanidin 3-O-beta-D-galactoside + UDP-alpha-D-xylose = cyanidin 3-O-[beta-D-xylosyl-(1->2)-beta-D-galactoside] + H(+) + UDP"}
{"X":37265,"RHEA_ID":45373,"compounds":"H2O + N-(9Z-octadecenoyl)-sphinganine => (9Z)-octadecenoate + sphinganine"}
{"X":37266,"RHEA_ID":45374,"compounds":"(9Z)-octadecenoate + sphinganine => H2O + N-(9Z-octadecenoyl)-sphinganine"}
{"X":37267,"RHEA_ID":45375,"compounds":"H2O + N-(9Z-octadecenoyl)-sphinganine <=> (9Z)-octadecenoate + sphinganine"}
{"X":37268,"RHEA_ID":35439,"DIRECTION":"UN","MASTER_ID":35439,"ec":"2.7.8.38","compounds":"CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol + L-serine = archaetidylserine + CMP + H(+)"}
{"X":37269,"RHEA_ID":45377,"compounds":"H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphinganine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + sphinganine"}
{"X":37270,"RHEA_ID":45378,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + sphinganine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphinganine"}
{"X":37271,"RHEA_ID":45379,"compounds":"H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphinganine <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + sphinganine"}
{"X":37272,"RHEA_ID":35443,"DIRECTION":"UN","MASTER_ID":35443,"ec":"2.4.2.51","metacyc":"RXN-13975","compounds":"an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-xylose = an anthocyanidin 3-O-beta-D-sambubioside + 2 H(+) + UDP"}
{"X":37273,"RHEA_ID":45381,"compounds":"H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4-hydroxysphinganine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 4-hydroxysphinganine"}
{"X":37274,"RHEA_ID":45382,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + 4-hydroxysphinganine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4-hydroxysphinganine"}
{"X":37275,"RHEA_ID":45383,"compounds":"H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4-hydroxysphinganine <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 4-hydroxysphinganine"}
{"X":37276,"RHEA_ID":35447,"DIRECTION":"UN","MASTER_ID":35447,"ec":"1.1.1.349","compounds":"(1'S)-averantin + NADP(+) = H(+) + NADPH + norsolorinic acid"}
{"X":37277,"RHEA_ID":45385,"compounds":"H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => (9Z)-octadecenoate + H(+) + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":37278,"RHEA_ID":45386,"compounds":"(9Z)-octadecenoate + H(+) + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine => H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":37279,"RHEA_ID":45387,"compounds":"H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z)-octadecenoate + H(+) + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":37280,"RHEA_ID":35455,"compounds":"5alpha-cholest-7-en-3-one + 2 H(+) + 3 NADPH + 3 O2 = (25S)-Delta7-dafachronate + 4 H2O + 3 NADP(+)"}
{"X":37281,"RHEA_ID":45389,"compounds":"H2O + N-octadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => (9Z)-octadecenoate + H(+) + N-octadecanoyl-sn-glycero-3-phospho-ethanolamine"}
{"X":37282,"RHEA_ID":35457,"compounds":"(25S)-Delta7-dafachronate + 4 H2O + 3 NADP(+) => 5alpha-cholest-7-en-3-one + 2 H(+) + 3 NADPH + 3 O2"}
{"X":37283,"RHEA_ID":35458,"compounds":"5alpha-cholest-7-en-3-one + 2 H(+) + 3 NADPH + 3 O2 <=> (25S)-Delta7-dafachronate + 4 H2O + 3 NADP(+)"}
{"X":37284,"RHEA_ID":35459,"compounds":"cholesterol + NAD(+) = cholest-5-en-3-one + H(+) + NADH"}
{"X":37285,"RHEA_ID":45393,"compounds":"H2O + N-eicosanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => (9Z)-octadecenoate + H(+) + N-eicosanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":37286,"RHEA_ID":35461,"compounds":"cholest-5-en-3-one + H(+) + NADH => cholesterol + NAD(+)"}
{"X":37287,"RHEA_ID":35462,"DIRECTION":"BI","MASTER_ID":35459,"metacyc":"RXN-12693","compounds":"cholesterol + NAD(+) <=> cholest-5-en-3-one + H(+) + NADH"}
{"X":37288,"RHEA_ID":35463,"compounds":"5alpha-cholest-7-en-3beta-ol + NAD(+) = 5alpha-cholest-7-en-3-one + H(+) + NADH"}
{"X":37289,"RHEA_ID":35464,"compounds":"5alpha-cholest-7-en-3beta-ol + NAD(+) => 5alpha-cholest-7-en-3-one + H(+) + NADH"}
{"X":37290,"RHEA_ID":45398,"compounds":"(9Z)-octadecenoate + H(+) + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":37291,"RHEA_ID":35466,"compounds":"5alpha-cholest-7-en-3beta-ol + NAD(+) <=> 5alpha-cholest-7-en-3-one + H(+) + NADH"}
{"X":37292,"RHEA_ID":35467,"DIRECTION":"UN","MASTER_ID":35467,"ec":"2.1.1.269","compounds":"(6S)-5,6,7,8-tetrahydrofolate + S,S-dimethyl-beta-propiothetin = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-(methylsulfanyl)propanoate + H(+)"}
{"X":37293,"RHEA_ID":35468,"DIRECTION":"LR","MASTER_ID":35467,"metacyc":"RXN-9736","compounds":"(6S)-5,6,7,8-tetrahydrofolate + S,S-dimethyl-beta-propiothetin => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-(methylsulfanyl)propanoate + H(+)"}
{"X":37294,"RHEA_ID":45402,"compounds":"(9Z)-octadecenoate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":37295,"RHEA_ID":45403,"compounds":"H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z)-octadecenoate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":37296,"RHEA_ID":35471,"DIRECTION":"UN","MASTER_ID":35471,"ec":"2.1.1.270","compounds":"(+)-6a-hydroxymaackiain + S-adenosyl-L-methionine = (+)-pisatin + H(+) + S-adenosyl-L-homocysteine"}
{"X":37297,"RHEA_ID":45405,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate => 1-O-(9Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":37298,"RHEA_ID":45406,"compounds":"1-O-(9Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate"}
{"X":37299,"RHEA_ID":45407,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate <=> 1-O-(9Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":37300,"RHEA_ID":35475,"DIRECTION":"UN","MASTER_ID":35475,"ec":"1.1.1.352","compounds":"(1'S,5'S)-5'-hydroxyaverantin + NAD(+) = (S)-5'-oxoaverantin + H(+) + NADH"}
{"X":37301,"RHEA_ID":45409,"compounds":"(2E)-dodecenoyl-CoA + H(+) + NADH => dodecanoyl-CoA + NAD(+)"}
{"X":37302,"RHEA_ID":35477,"compounds":"(S)-5'-oxoaverantin + H(+) + NADH => (1'S,5'S)-5'-hydroxyaverantin + NAD(+)"}
{"X":37303,"RHEA_ID":45411,"compounds":"(2E)-dodecenoyl-CoA + H(+) + NADH <=> dodecanoyl-CoA + NAD(+)"}
{"X":37304,"RHEA_ID":35479,"DIRECTION":"UN","MASTER_ID":35479,"ec":"1.1.1.352","compounds":"(1'S,5'R)-5'-hydroxyaverantin + NAD(+) = (S)-5'-oxoaverantin + 2 H(+) + NADH"}
{"X":37305,"RHEA_ID":45413,"compounds":"H2O + prostaglandin D2-1-glycerol ester => glycerol + H(+) + prostaglandin D2"}
{"X":37306,"RHEA_ID":45414,"compounds":"glycerol + H(+) + prostaglandin D2 => H2O + prostaglandin D2-1-glycerol ester"}
{"X":37307,"RHEA_ID":45415,"compounds":"H2O + prostaglandin D2-1-glycerol ester <=> glycerol + H(+) + prostaglandin D2"}
{"X":37308,"RHEA_ID":35483,"compounds":"5alpha-cholest-7-en-3-one + S-adenosyl-L-methionine = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + S-adenosyl-L-homocysteine"}
{"X":37309,"RHEA_ID":45417,"compounds":"11-oxo-5Z,9,12E,14E-prostatetraenoate + H2O => 15-deoxy-Delta(12,14)-prostaglandin J2 + glycerol + H(+)"}
{"X":37310,"RHEA_ID":45418,"compounds":"15-deoxy-Delta(12,14)-prostaglandin J2 + glycerol + H(+) => 11-oxo-5Z,9,12E,14E-prostatetraenoate + H2O"}
{"X":37311,"RHEA_ID":35486,"compounds":"5alpha-cholest-7-en-3-one + S-adenosyl-L-methionine <=> 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + S-adenosyl-L-homocysteine"}
{"X":37312,"RHEA_ID":35487,"DIRECTION":"UN","MASTER_ID":35487,"ec":"1.14.14.87","compounds":"(S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-2,3-dihydrogenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":37313,"RHEA_ID":45421,"compounds":"H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine => a fatty acid + H(+) + N-acyl-sn-glycero-3-phosphoethanolamine"}
{"X":37314,"RHEA_ID":45422,"compounds":"a fatty acid + H(+) + N-acyl-sn-glycero-3-phosphoethanolamine => H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine"}
{"X":37315,"RHEA_ID":45423,"compounds":"H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine <=> a fatty acid + H(+) + N-acyl-sn-glycero-3-phosphoethanolamine"}
{"X":37316,"RHEA_ID":35495,"compounds":"H2O + N-(4-aminobenzoyl)-L-glutamate = 4-aminobenzoate + L-glutamate"}
{"X":37317,"RHEA_ID":45425,"compounds":"H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => (9Z)-octadecenoate + H(+) + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":37318,"RHEA_ID":45426,"compounds":"(9Z)-octadecenoate + H(+) + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":37319,"RHEA_ID":35498,"compounds":"H2O + N-(4-aminobenzoyl)-L-glutamate <=> 4-aminobenzoate + L-glutamate"}
{"X":37320,"RHEA_ID":35499,"DIRECTION":"UN","MASTER_ID":35499,"ec":"1.14.14.115","compounds":"11-oxo-beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = glycyrrhetinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}
{"X":37321,"RHEA_ID":35500,"DIRECTION":"LR","MASTER_ID":35499,"metacyc":"RXN-13506","compounds":"11-oxo-beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => glycyrrhetinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}
{"X":37322,"RHEA_ID":35501,"compounds":"glycyrrhetinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 11-oxo-beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]"}
{"X":37323,"RHEA_ID":55421,"compounds":"hexadecanoyl-CoA + L-lysyl-[protein] => CoA + H(+) + N(6)-hexadecanoyl-L-lysyl-[protein]"}
{"X":37324,"RHEA_ID":35503,"compounds":"11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = 30-hydroxy-11-oxo-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":37325,"RHEA_ID":35504,"DIRECTION":"LR","MASTER_ID":35503,"metacyc":"RXN-13492","compounds":"11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => 30-hydroxy-11-oxo-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":37326,"RHEA_ID":35505,"compounds":"30-hydroxy-11-oxo-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":37327,"RHEA_ID":38840,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":37328,"RHEA_ID":35507,"compounds":"30-hydroxy-11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = glycyrrhetaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":37329,"RHEA_ID":35508,"DIRECTION":"LR","MASTER_ID":35507,"metacyc":"RXN-13493","compounds":"30-hydroxy-11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => glycyrrhetaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":37330,"RHEA_ID":35509,"compounds":"glycyrrhetaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 30-hydroxy-11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":37331,"RHEA_ID":55429,"DIRECTION":"LR","MASTER_ID":55428,"metacyc":"RXN-18880","compounds":"ferruginol + O2 + reduced [NADPH--hemoprotein reductase] => 11-hydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":37332,"RHEA_ID":35511,"compounds":"glycyrrhetaldehyde + O2 + reduced [NADPH--hemoprotein reductase] = glycyrrhetinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":37333,"RHEA_ID":35512,"DIRECTION":"LR","MASTER_ID":35511,"metacyc":"RXN-13494","compounds":"glycyrrhetaldehyde + O2 + reduced [NADPH--hemoprotein reductase] => glycyrrhetinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":37334,"RHEA_ID":35513,"compounds":"glycyrrhetinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => glycyrrhetaldehyde + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":37335,"RHEA_ID":45443,"compounds":"H2O + N-eicosanoyl-sn-glycero-3-phosphoethanolamine <=> H(+) + N-eicosanoyl ethanolamine + sn-glycerol 3-phosphate"}
{"X":37336,"RHEA_ID":35515,"DIRECTION":"UN","MASTER_ID":35515,"ec":"2.3.1.214","compounds":"4'''-demalonylsalvianin + malonyl-CoA = CoA + salvianin"}
{"X":37337,"RHEA_ID":35516,"DIRECTION":"LR","MASTER_ID":35515,"metacyc":"RXN-8139","compounds":"4'''-demalonylsalvianin + malonyl-CoA => CoA + salvianin"}
{"X":37338,"RHEA_ID":35517,"compounds":"CoA + salvianin => 4'''-demalonylsalvianin + malonyl-CoA"}
{"X":37339,"RHEA_ID":55437,"DIRECTION":"LR","MASTER_ID":55436,"metacyc":"RXN-18882","compounds":"ferruginol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + salviol"}
{"X":37340,"RHEA_ID":35519,"compounds":"(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl) ethanolamine + H2O = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ethanolamine"}
{"X":37341,"RHEA_ID":35520,"compounds":"(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl) ethanolamine + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ethanolamine"}
{"X":37342,"RHEA_ID":35521,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ethanolamine => (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl) ethanolamine + H2O"}
{"X":37343,"RHEA_ID":35522,"compounds":"(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl) ethanolamine + H2O <=> (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ethanolamine"}
{"X":37344,"RHEA_ID":45452,"compounds":"H2O + N-tetradecanoylethanolamine = ethanolamine + tetradecanoate"}
{"X":37345,"RHEA_ID":35524,"DIRECTION":"LR","MASTER_ID":35523,"ecocyc":"RXN0-5101","metacyc":"RXN0-5101","compounds":"H(+) + N-ethylmaleimide + NADPH => N-ethylsuccinimide + NADP(+)"}
{"X":37346,"RHEA_ID":35525,"compounds":"N-ethylsuccinimide + NADP(+) => H(+) + N-ethylmaleimide + NADPH"}
{"X":37347,"RHEA_ID":35526,"compounds":"H(+) + N-ethylmaleimide + NADPH <=> N-ethylsuccinimide + NADP(+)"}
{"X":37348,"RHEA_ID":45456,"compounds":"H2O + N-dodecanoylethanolamine = dodecanoate + ethanolamine"}
{"X":37349,"RHEA_ID":35528,"compounds":"H(+) + N-ethylmaleimide + NADH => N-ethylsuccinimide + NAD(+)"}
{"X":37350,"RHEA_ID":35529,"compounds":"N-ethylsuccinimide + NAD(+) => H(+) + N-ethylmaleimide + NADH"}
{"X":37351,"RHEA_ID":35530,"compounds":"H(+) + N-ethylmaleimide + NADH <=> N-ethylsuccinimide + NAD(+)"}
{"X":37352,"RHEA_ID":45460,"compounds":"H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine = a fatty acid + H(+) + N,1-diacyl-sn-glycero-3-phosphoethanolamine"}
{"X":37353,"RHEA_ID":35532,"DIRECTION":"LR","MASTER_ID":35531,"metacyc":"RXN-14310","compounds":"cyclo(L-phenylalanyl-L-leucyl) + 2 O2 => albonoursin + 2 H2O2"}
{"X":37354,"RHEA_ID":35533,"compounds":"albonoursin + 2 H2O2 => cyclo(L-phenylalanyl-L-leucyl) + 2 O2"}
{"X":37355,"RHEA_ID":45463,"compounds":"H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a fatty acid + H(+) + N,1-diacyl-sn-glycero-3-phosphoethanolamine"}
{"X":37356,"RHEA_ID":45464,"DIRECTION":"UN","MASTER_ID":45464,"ec":"1.14.19.10","compounds":"2 [Fe(II)-cytochrome b5] + eicosanoyl-CoA + 2 H(+) + O2 = (5Z)-eicosenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":37357,"RHEA_ID":35536,"DIRECTION":"LR","MASTER_ID":35535,"metacyc":"RXN-14308","compounds":"cyclo(L-phenylalanyl-L-leucyl) + O2 => cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + H2O2"}
{"X":37358,"RHEA_ID":35537,"compounds":"cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + H2O2 => cyclo(L-phenylalanyl-L-leucyl) + O2"}
{"X":37359,"RHEA_ID":45468,"DIRECTION":"UN","MASTER_ID":45468,"ec":"2.7.4.29","compounds":"alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + di-trans,octa-cis-undecaprenyl diphosphate = (Kdo)2-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate"}
{"X":37360,"RHEA_ID":35540,"DIRECTION":"LR","MASTER_ID":35539,"metacyc":"RXN-14309","compounds":"cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + O2 => albonoursin + H2O2"}
{"X":37361,"RHEA_ID":35541,"compounds":"albonoursin + H2O2 => cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + O2"}
{"X":37362,"RHEA_ID":55461,"DIRECTION":"LR","MASTER_ID":55460,"metacyc":"RXN-18902","compounds":"11-hydroxyferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 11-hydroxysugiol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":37363,"RHEA_ID":35543,"compounds":"3-phosphooxypyruvate + H2O = 3-hydroxypyruvate + phosphate"}
{"X":37364,"RHEA_ID":35544,"DIRECTION":"LR","MASTER_ID":35543,"ecocyc":"RXN0-6562","metacyc":"RXN0-6562","compounds":"3-phosphooxypyruvate + H2O => 3-hydroxypyruvate + phosphate"}
{"X":37365,"RHEA_ID":35545,"compounds":"3-hydroxypyruvate + phosphate => 3-phosphooxypyruvate + H2O"}
{"X":37366,"RHEA_ID":35546,"compounds":"3-phosphooxypyruvate + H2O <=> 3-hydroxypyruvate + phosphate"}
{"X":37367,"RHEA_ID":35547,"DIRECTION":"UN","MASTER_ID":35547,"ec":"1.14.19.70","compounds":"cyclo(L-tyrosyl-L-tyrosyl) + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + mycoclysin + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":37368,"RHEA_ID":35548,"DIRECTION":"LR","MASTER_ID":35547,"metacyc":"RXN-14313","compounds":"cyclo(L-tyrosyl-L-tyrosyl) + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + mycoclysin + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":37369,"RHEA_ID":35549,"compounds":"2 H2O + mycoclysin + 2 oxidized [2Fe-2S]-[ferredoxin] => cyclo(L-tyrosyl-L-tyrosyl) + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":37370,"RHEA_ID":45479,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":37371,"RHEA_ID":35555,"DIRECTION":"UN","MASTER_ID":35555,"ec":"1.14.15.13","compounds":"cyclo(L-leucyl-L-leucyl) + 4 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] = 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] + pulcherriminic acid"}
{"X":37372,"RHEA_ID":45481,"DIRECTION":"LR","MASTER_ID":45480,"metacyc":"LINA1-RXN","compounds":"gamma-hexachlorocyclohexane => (3R,4S,5S,6R)-pentachlorocyclohexene + chloride + H(+)"}
{"X":37373,"RHEA_ID":45482,"compounds":"(3R,4S,5S,6R)-pentachlorocyclohexene + chloride + H(+) => gamma-hexachlorocyclohexane"}
{"X":37374,"RHEA_ID":55473,"DIRECTION":"LR","MASTER_ID":55472,"metacyc":"RXN-18937","compounds":"9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-diene-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":37375,"RHEA_ID":45484,"DIRECTION":"UN","MASTER_ID":45484,"ec":"4.1.1.1","compounds":"H(+) + pyruvate = acetaldehyde + CO2"}
{"X":37376,"RHEA_ID":35560,"compounds":"H(+) + menaquinone-7 + NADH => menaquinol-7 + NAD(+)"}
{"X":37377,"RHEA_ID":45486,"compounds":"acetaldehyde + CO2 => H(+) + pyruvate"}
{"X":37378,"RHEA_ID":35562,"compounds":"H(+) + menaquinone-7 + NADH <=> menaquinol-7 + NAD(+)"}
{"X":37379,"RHEA_ID":45488,"DIRECTION":"UN","MASTER_ID":45488,"ec":"4.4.1.29","compounds":"[C-phycocyanin beta-subunit]-Cys(84)-phycocyanobilin = (2R,3E)-phycocyanobilin + apo-[C-phycocyanin beta-subunit]"}
{"X":37380,"RHEA_ID":35564,"compounds":"H2O + N-(9Z-hexadecenoyl) ethanolamine => (9Z)-hexadecenoate + ethanolamine"}
{"X":37381,"RHEA_ID":45490,"DIRECTION":"RL","MASTER_ID":45488,"metacyc":"RXN-15991","compounds":"(2R,3E)-phycocyanobilin + apo-[C-phycocyanin beta-subunit] => [C-phycocyanin beta-subunit]-Cys(84)-phycocyanobilin"}
{"X":37382,"RHEA_ID":35566,"compounds":"H2O + N-(9Z-hexadecenoyl) ethanolamine <=> (9Z)-hexadecenoate + ethanolamine"}
{"X":37383,"RHEA_ID":35567,"compounds":"H2O + linoleoyl ethanolamide = (9Z,12Z)-octadecadienoate + ethanolamine"}
{"X":37384,"RHEA_ID":35568,"compounds":"H2O + linoleoyl ethanolamide => (9Z,12Z)-octadecadienoate + ethanolamine"}
{"X":37385,"RHEA_ID":45494,"DIRECTION":"RL","MASTER_ID":45492,"metacyc":"RXN-15993","compounds":"(2R,3E)-phycocyanobilin + apo-[phycoerythrocyanin beta-subunit] => [phycoerythrocyanin beta-subunit]-Cys(84)-phycocyanobilin"}
{"X":37386,"RHEA_ID":35570,"compounds":"H2O + linoleoyl ethanolamide <=> (9Z,12Z)-octadecadienoate + ethanolamine"}
{"X":37387,"RHEA_ID":35571,"DIRECTION":"UN","MASTER_ID":35571,"ec":"1.14.14.116","compounds":"(1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase] = (1'S,5'S)-5'-hydroxyaverantin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":37388,"RHEA_ID":35572,"DIRECTION":"LR","MASTER_ID":35571,"metacyc":"RXN-9481","compounds":"(1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase] => (1'S,5'S)-5'-hydroxyaverantin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":37389,"RHEA_ID":45498,"DIRECTION":"RL","MASTER_ID":45496,"metacyc":"RXN-15996","compounds":"(2R,3E)-phycocyanobilin + apo-[allophycocyanin alpha-subunit] => [allophycocyanin alpha-subunit]-Cys(84)-phycocyanobilin"}
{"X":37390,"RHEA_ID":45499,"compounds":"[allophycocyanin alpha-subunit]-Cys(84)-phycocyanobilin <=> (2R,3E)-phycocyanobilin + apo-[allophycocyanin alpha-subunit]"}
{"X":37391,"RHEA_ID":45500,"DIRECTION":"UN","MASTER_ID":45500,"ec":"4.4.1.29","compounds":"[allophycocyanin beta-subunit]-Cys(84)-phycocyanobilin = (2R,3E)-phycocyanobilin + apo-[allophycocyanin beta-subunit]"}
{"X":37392,"RHEA_ID":35576,"DIRECTION":"LR","MASTER_ID":35575,"metacyc":"RXN-9482","compounds":"(1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase] => (1'S,5'R)-5'-hydroxyaverantin + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":37393,"RHEA_ID":45502,"DIRECTION":"RL","MASTER_ID":45500,"metacyc":"RXN-15995","compounds":"(2R,3E)-phycocyanobilin + apo-[allophycocyanin beta-subunit] => [allophycocyanin beta-subunit]-Cys(84)-phycocyanobilin"}
{"X":37394,"RHEA_ID":45503,"compounds":"[allophycocyanin beta-subunit]-Cys(84)-phycocyanobilin <=> (2R,3E)-phycocyanobilin + apo-[allophycocyanin beta-subunit]"}
{"X":37395,"RHEA_ID":35579,"DIRECTION":"UN","MASTER_ID":35579,"ec":"2.3.1.n12","metacyc":"RXN-14355","compounds":"1-O-(trans-sinapoyl)-beta-D-glucose + cyanidin 3-O-[6-O-(4-O-beta-D-glucosyl-p-coumaroyl)-2-O-(beta-D-xylosyl)-beta-D-glucosyl]-5-O-(6-O-malonyl-beta-D-glucoside) = cyanidin 3-O-[6-O-(4-O-beta-D-glucosyl-p-coumaroyl)-2-O-(2-O-sinapoyl-beta-D-xylosyl)-beta-D-glucosyl]-5-O-(6-O-malonyl-beta-D-glucoside) + D-glucose"}
{"X":37396,"RHEA_ID":35580,"compounds":"1-O-(trans-sinapoyl)-beta-D-glucose + cyanidin 3-O-[6-O-(4-O-beta-D-glucosyl-p-coumaroyl)-2-O-(beta-D-xylosyl)-beta-D-glucosyl]-5-O-(6-O-malonyl-beta-D-glucoside) => cyanidin 3-O-[6-O-(4-O-beta-D-glucosyl-p-coumaroyl)-2-O-(2-O-sinapoyl-beta-D-xylosyl)-beta-D-glucosyl]-5-O-(6-O-malonyl-beta-D-glucoside) + D-glucose"}
{"X":37397,"RHEA_ID":35581,"compounds":"cyanidin 3-O-[6-O-(4-O-beta-D-glucosyl-p-coumaroyl)-2-O-(2-O-sinapoyl-beta-D-xylosyl)-beta-D-glucosyl]-5-O-(6-O-malonyl-beta-D-glucoside) + D-glucose => 1-O-(trans-sinapoyl)-beta-D-glucose + cyanidin 3-O-[6-O-(4-O-beta-D-glucosyl-p-coumaroyl)-2-O-(beta-D-xylosyl)-beta-D-glucosyl]-5-O-(6-O-malonyl-beta-D-glucoside)"}
{"X":37398,"RHEA_ID":35582,"compounds":"1-O-(trans-sinapoyl)-beta-D-glucose + cyanidin 3-O-[6-O-(4-O-beta-D-glucosyl-p-coumaroyl)-2-O-(beta-D-xylosyl)-beta-D-glucosyl]-5-O-(6-O-malonyl-beta-D-glucoside) <=> cyanidin 3-O-[6-O-(4-O-beta-D-glucosyl-p-coumaroyl)-2-O-(2-O-sinapoyl-beta-D-xylosyl)-beta-D-glucosyl]-5-O-(6-O-malonyl-beta-D-glucoside) + D-glucose"}
{"X":37399,"RHEA_ID":35583,"DIRECTION":"UN","MASTER_ID":35583,"ec":"4.1.2.51","compounds":"2-dehydro-3-deoxy-D-gluconate = D-glyceraldehyde + pyruvate"}
{"X":37400,"RHEA_ID":35584,"compounds":"2-dehydro-3-deoxy-D-gluconate => D-glyceraldehyde + pyruvate"}
{"X":37401,"RHEA_ID":45510,"DIRECTION":"RL","MASTER_ID":45508,"metacyc":"RXN-15998","compounds":"(2R,3E)-phycoerythrobilin + apo-[C-phycoerythrin beta-subunit] => [C-phycoerythrin beta-subunit]-Cys(84)-phycoerythrobilin"}
{"X":37402,"RHEA_ID":45512,"DIRECTION":"UN","MASTER_ID":45512,"ec":"4.4.1.30","compounds":"[C-phycocyanin beta-subunit]-Cys(155)-phycocyanobilin = (2R,3E)-phycocyanobilin + apo-[C-phycocyanin beta-subunit]-Cys(155)"}
{"X":37403,"RHEA_ID":35588,"DIRECTION":"LR","MASTER_ID":35587,"ecocyc":"RXN0-5187","metacyc":"RXN0-5187","reactome":"R-HSA-196950.2","compounds":"FMN + H2O => phosphate + riboflavin"}
{"X":37404,"RHEA_ID":45514,"DIRECTION":"RL","MASTER_ID":45512,"metacyc":"RXN-15992","compounds":"(2R,3E)-phycocyanobilin + apo-[C-phycocyanin beta-subunit]-Cys(155) => [C-phycocyanin beta-subunit]-Cys(155)-phycocyanobilin"}
{"X":37405,"RHEA_ID":45515,"compounds":"[C-phycocyanin beta-subunit]-Cys(155)-phycocyanobilin <=> (2R,3E)-phycocyanobilin + apo-[C-phycocyanin beta-subunit]-Cys(155)"}
{"X":37406,"RHEA_ID":45516,"DIRECTION":"UN","MASTER_ID":45516,"ec":"4.4.1.30","compounds":"[phycoerythrocyanin beta-subunit]-Cys(155)-phycocyanobilin = (2R,3E)-phycocyanobilin + apo-[phycoerythrocyanin beta-subunit]-Cys(155)"}
{"X":37407,"RHEA_ID":35592,"DIRECTION":"LR","MASTER_ID":35591,"metacyc":"RXN-8269","compounds":"H2 + n sulfur => H(+) + hydrogen sulfide + (n-1) sulfur"}
{"X":37408,"RHEA_ID":45518,"DIRECTION":"RL","MASTER_ID":45516,"metacyc":"RXN-15994","compounds":"(2R,3E)-phycocyanobilin + apo-[phycoerythrocyanin beta-subunit]-Cys(155) => [phycoerythrocyanin beta-subunit]-Cys(155)-phycocyanobilin"}
{"X":37409,"RHEA_ID":45520,"DIRECTION":"UN","MASTER_ID":45520,"ec":"4.4.1.31","compounds":"[phycoerythrocyanin alpha-subunit]-Cys(84)-phycoviolobilin = (2R,3E)-phycocyanobilin + apo-[phycoerythrocyanin alpha-subunit]"}
{"X":37410,"RHEA_ID":35596,"DIRECTION":"LR","MASTER_ID":35595,"metacyc":"RXN-10137","compounds":"benzene-1,2,4-triol + O2 => 2 H(+) + maleylacetate"}
{"X":37411,"RHEA_ID":35597,"compounds":"2 H(+) + maleylacetate => benzene-1,2,4-triol + O2"}
{"X":37412,"RHEA_ID":55512,"compounds":"cucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase] = 11-hydroxycucurbitadienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":37413,"RHEA_ID":55513,"DIRECTION":"LR","MASTER_ID":55512,"metacyc":"RXN-18953","compounds":"cucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase] => 11-hydroxycucurbitadienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":37414,"RHEA_ID":35600,"compounds":"NADP(+) + propane-1,3-diol => 3-hydroxypropanal + H(+) + NADPH"}
{"X":37415,"RHEA_ID":35601,"compounds":"3-hydroxypropanal + H(+) + NADPH => NADP(+) + propane-1,3-diol"}
{"X":37416,"RHEA_ID":35602,"DIRECTION":"BI","MASTER_ID":35599,"ecocyc":"RXN0-6487","metacyc":"RXN0-6487","compounds":"NADP(+) + propane-1,3-diol <=> 3-hydroxypropanal + H(+) + NADPH"}
{"X":37417,"RHEA_ID":45528,"compounds":"H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine"}
{"X":37418,"RHEA_ID":35604,"DIRECTION":"LR","MASTER_ID":35603,"ecocyc":"RXN0-5186","metacyc":"RXN0-5186","compounds":"beta-D-fructose 1-phosphate + H2O => D-fructose + phosphate"}
{"X":37419,"RHEA_ID":35605,"compounds":"D-fructose + phosphate => beta-D-fructose 1-phosphate + H2O"}
{"X":37420,"RHEA_ID":45531,"compounds":"H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine"}
{"X":37421,"RHEA_ID":45532,"compounds":"H2O + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine"}
{"X":37422,"RHEA_ID":35608,"compounds":"acetoin + NADP(+) => diacetyl + H(+) + NADPH"}
{"X":37423,"RHEA_ID":35609,"DIRECTION":"RL","MASTER_ID":35607,"metacyc":"ACETOINDEHYDROG-A-RXN","compounds":"diacetyl + H(+) + NADPH => acetoin + NADP(+)"}
{"X":37424,"RHEA_ID":35610,"DIRECTION":"BI","MASTER_ID":35607,"ecocyc":"ACETOINDEHYDROG-A-RXN","metacyc":"ACETOINDEHYDROG-A-RXN","compounds":"acetoin + NADP(+) <=> diacetyl + H(+) + NADPH"}
{"X":37425,"RHEA_ID":45536,"compounds":"H2O + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-octadecanoyl ethanolamine"}
{"X":37426,"RHEA_ID":35612,"compounds":"menadiol + 2 O2 => 2 H(+) + menadione + 2 superoxide"}
{"X":37427,"RHEA_ID":35613,"compounds":"2 H(+) + menadione + 2 superoxide => menadiol + 2 O2"}
{"X":37428,"RHEA_ID":35614,"compounds":"menadiol + 2 O2 <=> 2 H(+) + menadione + 2 superoxide"}
{"X":37429,"RHEA_ID":55529,"DIRECTION":"LR","MASTER_ID":55528,"metacyc":"RXN-19274","compounds":"H(+) + H2O + L-tyrosine + O2 => (4-hydroxyphenyl)acetaldehyde + CO2 + H2O2 + NH4(+)"}
{"X":37430,"RHEA_ID":35616,"compounds":"hydroxyacetone + NAD(+) => H(+) + methylglyoxal + NADH"}
{"X":37431,"RHEA_ID":35617,"DIRECTION":"RL","MASTER_ID":35615,"ecocyc":"RXN0-5213","metacyc":"RXN0-5213","compounds":"H(+) + methylglyoxal + NADH => hydroxyacetone + NAD(+)"}
{"X":37432,"RHEA_ID":45544,"compounds":"H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine"}
{"X":37433,"RHEA_ID":35620,"compounds":"L-idarate => D-glucarate"}
{"X":37434,"RHEA_ID":35621,"compounds":"D-glucarate => L-idarate"}
{"X":37435,"RHEA_ID":35622,"DIRECTION":"BI","MASTER_ID":35619,"ecocyc":"RXN0-5285","metacyc":"RXN0-5285","compounds":"L-idarate <=> D-glucarate"}
{"X":37436,"RHEA_ID":45548,"DIRECTION":"UN","MASTER_ID":45548,"ec":"4.4.1.33","compounds":"[R-phycocyanin alpha-subunit]-Cys(84)-phycourobilin = (2R,3E)-phycoerythrobilin + apo-[R-phycocyanin alpha-subunit]"}
{"X":37437,"RHEA_ID":35624,"compounds":"D-glutamate + D-glutamine => D-gamma-glutamyl-D-glutamate + NH4(+)"}
{"X":37438,"RHEA_ID":35625,"compounds":"D-gamma-glutamyl-D-glutamate + NH4(+) => D-glutamate + D-glutamine"}
{"X":37439,"RHEA_ID":45552,"compounds":"H2O + N-tetradecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-tetradecanoylethanolamine"}
{"X":37440,"RHEA_ID":35628,"DIRECTION":"LR","MASTER_ID":35627,"metacyc":"RXN-8231","compounds":"delphinidin 3,5-bis-O-beta-D-glucoside + UDP-alpha-D-glucose => delphinidin 3,3',5-tri-O-beta-D-glucoside + H(+) + UDP"}
{"X":37441,"RHEA_ID":35629,"compounds":"delphinidin 3,3',5-tri-O-beta-D-glucoside + H(+) + UDP => delphinidin 3,5-bis-O-beta-D-glucoside + UDP-alpha-D-glucose"}
{"X":37442,"RHEA_ID":45555,"compounds":"H2O + N-tetradecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-tetradecanoylethanolamine"}
{"X":37443,"RHEA_ID":35631,"DIRECTION":"UN","MASTER_ID":35631,"ec":"2.4.1.294","compounds":"cyanidin + UDP-alpha-D-galactose = cyanidin 3-O-beta-D-galactoside + H(+) + UDP"}
{"X":37444,"RHEA_ID":45557,"compounds":"H2O + N-dodecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-dodecanoylethanolamine"}
{"X":37445,"RHEA_ID":35633,"compounds":"cyanidin 3-O-beta-D-galactoside + H(+) + UDP => cyanidin + UDP-alpha-D-galactose"}
{"X":37446,"RHEA_ID":45559,"compounds":"H2O + N-dodecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-dodecanoylethanolamine"}
{"X":37447,"RHEA_ID":45560,"DIRECTION":"UN","MASTER_ID":45560,"ec":"5.1.1.21","compounds":"L-isoleucine = D-allo-isoleucine"}
{"X":37448,"RHEA_ID":45561,"compounds":"L-isoleucine => D-allo-isoleucine"}
{"X":37449,"RHEA_ID":35637,"compounds":"an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] 5-O-beta-D-glucoside + H(+) + UDP => an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + UDP-alpha-D-glucose"}
{"X":37450,"RHEA_ID":55552,"compounds":"N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine"}
{"X":37451,"RHEA_ID":35639,"DIRECTION":"UN","MASTER_ID":35639,"ec":"4.1.3.42","compounds":"(4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate"}
{"X":37452,"RHEA_ID":35640,"compounds":"(4S)-4-hydroxy-2-oxoglutarate => glyoxylate + pyruvate"}
{"X":37453,"RHEA_ID":35641,"compounds":"glyoxylate + pyruvate => (4S)-4-hydroxy-2-oxoglutarate"}
{"X":37454,"RHEA_ID":35643,"DIRECTION":"UN","MASTER_ID":35643,"ec":"1.1.1.345","compounds":"a (2R)-2-hydroxycarboxylate + NAD(+) = a 2-oxocarboxylate + H(+) + NADH"}
{"X":37455,"RHEA_ID":45569,"compounds":"[heparosan](n) => [acharan](n)"}
{"X":37456,"RHEA_ID":35645,"compounds":"a 2-oxocarboxylate + H(+) + NADH => a (2R)-2-hydroxycarboxylate + NAD(+)"}
{"X":37457,"RHEA_ID":35646,"DIRECTION":"BI","MASTER_ID":35643,"metacyc":"RXN-14183","compounds":"a (2R)-2-hydroxycarboxylate + NAD(+) <=> a 2-oxocarboxylate + H(+) + NADH"}
{"X":37458,"RHEA_ID":45572,"DIRECTION":"UN","MASTER_ID":45572,"ec":"5.1.3.37","compounds":"[(1->4)-beta-D-mannuronosyl](n) = [alginate](n)"}
{"X":37459,"RHEA_ID":45573,"compounds":"[(1->4)-beta-D-mannuronosyl](n) => [alginate](n)"}
{"X":37460,"RHEA_ID":35649,"compounds":"3',3'-cGAMP + 2 diphosphate => ATP + GTP"}
{"X":37461,"RHEA_ID":35650,"compounds":"ATP + GTP <=> 3',3'-cGAMP + 2 diphosphate"}
{"X":37462,"RHEA_ID":45576,"DIRECTION":"UN","MASTER_ID":45576,"ec":"5.4.99.63","compounds":"(2R)-ethylmalonyl-CoA = (2S)-methylsuccinyl-CoA"}
{"X":37463,"RHEA_ID":45577,"DIRECTION":"LR","MASTER_ID":45576,"metacyc":"RXN-8958","compounds":"(2R)-ethylmalonyl-CoA => (2S)-methylsuccinyl-CoA"}
{"X":37464,"RHEA_ID":35653,"compounds":"an N-acyl-(4R)-4-hydroxysphinganine + CoA + H(+) => 4-hydroxysphinganine + an acyl-CoA"}
{"X":37465,"RHEA_ID":35654,"compounds":"4-hydroxysphinganine + an acyl-CoA <=> an N-acyl-(4R)-4-hydroxysphinganine + CoA + H(+)"}
{"X":37466,"RHEA_ID":35655,"DIRECTION":"UN","MASTER_ID":35655,"ec":"2.7.7.85","compounds":"2 ATP = 3',3'-c-di-AMP + 2 diphosphate"}
{"X":37467,"RHEA_ID":45581,"DIRECTION":"LR","MASTER_ID":45580,"metacyc":"RXN-15901","compounds":"D-galactaro-1,5-lactone => D-galactaro-1,4-lactone"}
{"X":37468,"RHEA_ID":35657,"compounds":"3',3'-c-di-AMP + 2 diphosphate => 2 ATP"}
{"X":37469,"RHEA_ID":55572,"compounds":"4-hydoxytryptamine 4-phosphate + S-adenosyl-L-methionine = 4-hydroxy-N-methyltryptamine 4-phosphate + H(+) + S-adenosyl-L-homocysteine"}
{"X":37470,"RHEA_ID":45584,"compounds":"3-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O"}
{"X":37471,"RHEA_ID":45585,"compounds":"3-hydroxybutanoyl-CoA => (2E)-butenoyl-CoA + H2O"}
{"X":37472,"RHEA_ID":35661,"compounds":"GDP + H(+) + mannosylinositol phosphorylphytoceramide => an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + GDP-alpha-D-mannose"}
{"X":37473,"RHEA_ID":35662,"compounds":"an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + GDP-alpha-D-mannose <=> GDP + H(+) + mannosylinositol phosphorylphytoceramide"}
{"X":37474,"RHEA_ID":45588,"DIRECTION":"UN","MASTER_ID":45588,"ec":"6.2.1.20","compounds":"a long-chain fatty acid + ATP + holo-[ACP] = a long-chain fatty acyl-[ACP] + AMP + diphosphate"}
{"X":37475,"RHEA_ID":35664,"compounds":"a 1,2-diacyl-sn-glycerol + H2O => a 1-acyl-sn-glycerol + a fatty acid + H(+)"}
{"X":37476,"RHEA_ID":35665,"compounds":"a 1-acyl-sn-glycerol + a fatty acid + H(+) => a 1,2-diacyl-sn-glycerol + H2O"}
{"X":37477,"RHEA_ID":35666,"compounds":"a 1,2-diacyl-sn-glycerol + H2O <=> a 1-acyl-sn-glycerol + a fatty acid + H(+)"}
{"X":37478,"RHEA_ID":45592,"compounds":"H2O + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}
{"X":37479,"RHEA_ID":45593,"compounds":"H2O + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}
{"X":37480,"RHEA_ID":35669,"compounds":"a 1,2-diacylglycerol + a fatty acid + H(+) => a triacylglycerol + H2O"}
{"X":37481,"RHEA_ID":35670,"compounds":"a triacylglycerol + H2O <=> a 1,2-diacylglycerol + a fatty acid + H(+)"}
{"X":37482,"RHEA_ID":35671,"DIRECTION":"UN","MASTER_ID":35671,"ec":"4.2.1.142","compounds":"(S)-5'-oxoaverantin + H(+) = (1'S,5'S)-averufin + H2O"}
{"X":37483,"RHEA_ID":45597,"compounds":"H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}
{"X":37484,"RHEA_ID":35673,"compounds":"(1'S,5'S)-averufin + H2O => (S)-5'-oxoaverantin + H(+)"}
{"X":37485,"RHEA_ID":45599,"compounds":"H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}
{"X":37486,"RHEA_ID":45600,"DIRECTION":"UN","MASTER_ID":45600,"ec":"5.5.1.27","compounds":"D-galactaro-1,4-lactone = 5-dehydro-4-deoxy-D-glucarate + H(+)"}
{"X":37487,"RHEA_ID":35676,"compounds":"H(+) + L-serine + tetradecanoyl-CoA => 3-oxohexadecasphinganine + CO2 + CoA"}
{"X":37488,"RHEA_ID":35677,"compounds":"3-oxohexadecasphinganine + CO2 + CoA => H(+) + L-serine + tetradecanoyl-CoA"}
{"X":37489,"RHEA_ID":35678,"compounds":"H(+) + L-serine + tetradecanoyl-CoA <=> 3-oxohexadecasphinganine + CO2 + CoA"}
{"X":37490,"RHEA_ID":45604,"DIRECTION":"UN","MASTER_ID":45604,"ec":"5.5.1.27","compounds":"D-glucaro-1,4-lactone = 5-dehydro-4-deoxy-D-glucarate + H(+)"}
{"X":37491,"RHEA_ID":45605,"DIRECTION":"LR","MASTER_ID":45604,"metacyc":"RXN-15907","compounds":"D-glucaro-1,4-lactone => 5-dehydro-4-deoxy-D-glucarate + H(+)"}
{"X":37492,"RHEA_ID":35681,"compounds":"3-oxotetradecasphinganine + CO2 + CoA => dodecanoyl-CoA + H(+) + L-serine"}
{"X":37493,"RHEA_ID":35682,"compounds":"dodecanoyl-CoA + H(+) + L-serine <=> 3-oxotetradecasphinganine + CO2 + CoA"}
{"X":37494,"RHEA_ID":45608,"compounds":"H2O + N-decanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-decanoyl ethanolamine"}
{"X":37495,"RHEA_ID":45609,"compounds":"H2O + N-decanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-decanoyl ethanolamine"}
{"X":37496,"RHEA_ID":35685,"compounds":"3-oxohexadecasphinganine + H(+) + NADPH => hexadecasphinganine + NADP(+)"}
{"X":37497,"RHEA_ID":35686,"compounds":"hexadecasphinganine + NADP(+) <=> 3-oxohexadecasphinganine + H(+) + NADPH"}
{"X":37498,"RHEA_ID":35687,"compounds":"NADP(+) + tetradecasphinganine = 3-oxotetradecasphinganine + H(+) + NADPH"}
{"X":37499,"RHEA_ID":45613,"compounds":"H2O + N-octanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-octanoyl ethanolamine"}
{"X":37500,"RHEA_ID":35689,"compounds":"3-oxotetradecasphinganine + H(+) + NADPH => NADP(+) + tetradecasphinganine"}
{"X":37501,"RHEA_ID":35690,"compounds":"NADP(+) + tetradecasphinganine <=> 3-oxotetradecasphinganine + H(+) + NADPH"}
{"X":37502,"RHEA_ID":45616,"compounds":"H2O + N-hexanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexanoyl ethanolamine"}
{"X":37503,"RHEA_ID":45617,"compounds":"H2O + N-hexanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexanoyl ethanolamine"}
{"X":37504,"RHEA_ID":35693,"DIRECTION":"RL","MASTER_ID":35691,"metacyc":"RXN-9489","compounds":"1'-hydroxyversicolorone + H(+) + NADPH => (2S)-versicolorone + NADP(+)"}
{"X":37505,"RHEA_ID":45619,"compounds":"H2O + N-hexanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexanoyl ethanolamine"}
{"X":37506,"RHEA_ID":45620,"compounds":"H2O + N-butanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-butanoyl ethanolamine"}
{"X":37507,"RHEA_ID":45621,"compounds":"H2O + N-butanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-butanoyl ethanolamine"}
{"X":37508,"RHEA_ID":35697,"DIRECTION":"RL","MASTER_ID":35695,"metacyc":"RXN-9490","compounds":"(2S,3S)-versiconal hemiacetal acetate + H(+) + NADPH => (3S)-versiconol acetate + NADP(+)"}
{"X":37509,"RHEA_ID":45623,"compounds":"H2O + N-butanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-butanoyl ethanolamine"}
{"X":37510,"RHEA_ID":35699,"DIRECTION":"UN","MASTER_ID":35699,"ec":"1.1.1.353","compounds":"(S)-versiconol + NADP(+) = (2S-3S)-versiconal hemiacetal + H(+) + NADPH"}
{"X":37511,"RHEA_ID":45625,"compounds":"ATP + holo-[CmaA peptidyl-carrier protein] + L-alloisoleucine => AMP + diphosphate + L-alloisoleucyl-[CmaA peptidyl-carrier protein]"}
{"X":37512,"RHEA_ID":35701,"DIRECTION":"RL","MASTER_ID":35699,"metacyc":"RXN-9491","compounds":"(2S-3S)-versiconal hemiacetal + H(+) + NADPH => (S)-versiconol + NADP(+)"}
{"X":37513,"RHEA_ID":55620,"DIRECTION":"UN","MASTER_ID":55620,"ec":"5.5.1.19","compounds":"a carotenoid psi-end group = a carotenoid beta-end derivative"}
{"X":37514,"RHEA_ID":35703,"compounds":"1'-hydroxyversicolorone + H(+) + NADPH + O2 = (2S,3S)-versiconal hemiacetal acetate + H2O + NADP(+)"}
{"X":37515,"RHEA_ID":45629,"compounds":"holo-[CmaD peptidyl-carrier protein] + L-alloisoleucyl-[CmaA peptidyl-carrier protein] => holo-[CmaA peptidyl-carrier protein] + L-alloisoleucyl-[CmaD peptidyl-carrier protein]"}
{"X":37516,"RHEA_ID":35705,"compounds":"(2S,3S)-versiconal hemiacetal acetate + H2O + NADP(+) => 1'-hydroxyversicolorone + H(+) + NADPH + O2"}
{"X":37517,"RHEA_ID":35706,"compounds":"1'-hydroxyversicolorone + H(+) + NADPH + O2 <=> (2S,3S)-versiconal hemiacetal acetate + H2O + NADP(+)"}
{"X":37518,"RHEA_ID":45632,"compounds":"1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate"}
{"X":37519,"RHEA_ID":45633,"compounds":"1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate"}
{"X":37520,"RHEA_ID":35709,"compounds":"(3S)-versiconol acetate + H2O + NADP(+) => (2S)-versicolorone + H(+) + NADPH + O2"}
{"X":37521,"RHEA_ID":35710,"compounds":"(2S)-versicolorone + H(+) + NADPH + O2 <=> (3S)-versiconol acetate + H2O + NADP(+)"}
{"X":37522,"RHEA_ID":35711,"DIRECTION":"UN","MASTER_ID":35711,"ec":"2.8.3.18","compounds":"acetate + succinyl-CoA = acetyl-CoA + succinate"}
{"X":37523,"RHEA_ID":45637,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate"}
{"X":37524,"RHEA_ID":35713,"compounds":"acetyl-CoA + succinate => acetate + succinyl-CoA"}
{"X":37525,"RHEA_ID":45639,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate"}
{"X":37526,"RHEA_ID":45640,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}
{"X":37527,"RHEA_ID":45641,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}
{"X":37528,"RHEA_ID":35717,"compounds":"(2S-3S)-versiconal hemiacetal + acetate + H(+) => (2S,3S)-versiconal hemiacetal acetate + H2O"}
{"X":37529,"RHEA_ID":45643,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}
{"X":37530,"RHEA_ID":45644,"compounds":"H2O + N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine = H(+) + N-hexadecanoylsphing-4-enine + phosphocholine"}
{"X":37531,"RHEA_ID":45645,"compounds":"H2O + N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine => H(+) + N-hexadecanoylsphing-4-enine + phosphocholine"}
{"X":37532,"RHEA_ID":35721,"compounds":"(S)-versiconol + acetate + H(+) => (3S)-versiconol acetate + H2O"}
{"X":37533,"RHEA_ID":45647,"compounds":"H2O + N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine <=> H(+) + N-hexadecanoylsphing-4-enine + phosphocholine"}
{"X":37534,"RHEA_ID":35723,"compounds":"hexadecanoyl-CoA + sn-glycerol 3-phosphate = 1-hexadecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":37535,"RHEA_ID":35724,"compounds":"hexadecanoyl-CoA + sn-glycerol 3-phosphate => 1-hexadecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":37536,"RHEA_ID":39054,"compounds":"ATP + cholesterol(in) + H2O <=> ADP + cholesterol(out) + H(+) + phosphate"}
{"X":37537,"RHEA_ID":35726,"compounds":"hexadecanoyl-CoA + sn-glycerol 3-phosphate <=> 1-hexadecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":37538,"RHEA_ID":45652,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}
{"X":37539,"RHEA_ID":35728,"compounds":"dodecanoyl-CoA + sn-glycerol 3-phosphate => 1-dodecanoyl-sn-glycerol 3-phosphate + CoA"}
{"X":37540,"RHEA_ID":45654,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+)"}
{"X":37541,"RHEA_ID":35730,"compounds":"dodecanoyl-CoA + sn-glycerol 3-phosphate <=> 1-dodecanoyl-sn-glycerol 3-phosphate + CoA"}
{"X":37542,"RHEA_ID":45656,"compounds":"1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CTP + H(+) = 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}
{"X":37543,"RHEA_ID":35732,"compounds":"sn-glycerol 3-phosphate + tetradecanoyl-CoA => 1-tetradecanoyl-sn-glycerol 3-phosphate + CoA"}
{"X":37544,"RHEA_ID":45658,"compounds":"1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CTP + H(+)"}
{"X":37545,"RHEA_ID":35734,"compounds":"sn-glycerol 3-phosphate + tetradecanoyl-CoA <=> 1-tetradecanoyl-sn-glycerol 3-phosphate + CoA"}
{"X":37546,"RHEA_ID":45660,"compounds":"1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}
{"X":37547,"RHEA_ID":35736,"compounds":"a (2R)-2-hydroxycarboxylate + NADP(+) => a 2-oxocarboxylate + H(+) + NADPH"}
{"X":37548,"RHEA_ID":35737,"compounds":"a 2-oxocarboxylate + H(+) + NADPH => a (2R)-2-hydroxycarboxylate + NADP(+)"}
{"X":37549,"RHEA_ID":35738,"DIRECTION":"BI","MASTER_ID":35735,"metacyc":"1.1.1.272-RXN","compounds":"a (2R)-2-hydroxycarboxylate + NADP(+) <=> a 2-oxocarboxylate + H(+) + NADPH"}
{"X":37550,"RHEA_ID":45664,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}
{"X":37551,"RHEA_ID":35740,"DIRECTION":"LR","MASTER_ID":35739,"metacyc":"1.14.15.6-RXN","compounds":"cholesterol + 6 H(+) + 3 O2 + 6 reduced [adrenodoxin] => 4-methylpentanal + 4 H2O + 6 oxidized [adrenodoxin] + pregnenolone"}
{"X":37552,"RHEA_ID":35741,"compounds":"4-methylpentanal + 4 H2O + 6 oxidized [adrenodoxin] + pregnenolone => cholesterol + 6 H(+) + 3 O2 + 6 reduced [adrenodoxin]"}
{"X":37553,"RHEA_ID":45667,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}
{"X":37554,"RHEA_ID":45668,"compounds":"1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}
{"X":37555,"RHEA_ID":35744,"DIRECTION":"LR","MASTER_ID":35743,"metacyc":"RXN-9495","compounds":"H(+) + NADPH + O2 + versicolorin B => 2 H2O + NADP(+) + versicolorin A"}
{"X":37556,"RHEA_ID":35745,"compounds":"2 H2O + NADP(+) + versicolorin A => H(+) + NADPH + O2 + versicolorin B"}
{"X":37557,"RHEA_ID":45671,"compounds":"1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}
{"X":37558,"RHEA_ID":45672,"compounds":"1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}
{"X":37559,"RHEA_ID":35748,"DIRECTION":"LR","MASTER_ID":35747,"metacyc":"RXN-14015","compounds":"(2E,6E)-farnesyl diphosphate => 7-epizingiberene + diphosphate"}
{"X":37560,"RHEA_ID":45674,"compounds":"1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+)"}
{"X":37561,"RHEA_ID":45675,"compounds":"1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}
{"X":37562,"RHEA_ID":45676,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}
{"X":37563,"RHEA_ID":35752,"DIRECTION":"LR","MASTER_ID":35751,"metacyc":"RXN-9581","compounds":"ATP + kanosamine => ADP + D-kanosamine 6-phosphate + H(+)"}
{"X":37564,"RHEA_ID":45678,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+)"}
{"X":37565,"RHEA_ID":45679,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}
{"X":37566,"RHEA_ID":45680,"compounds":"N-(hexadecanoyl)-sphing-4-enine-1-phosphate(in) = N-(hexadecanoyl)-sphing-4-enine-1-phosphate(out)"}
{"X":37567,"RHEA_ID":35756,"DIRECTION":"LR","MASTER_ID":35755,"metacyc":"RXN-9578","compounds":"NAD(+) + UDP-alpha-D-glucose => H(+) + NADH + UDP-3-oxo-alpha-D-glucose"}
{"X":37568,"RHEA_ID":35757,"compounds":"H(+) + NADH + UDP-3-oxo-alpha-D-glucose => NAD(+) + UDP-alpha-D-glucose"}
{"X":37569,"RHEA_ID":45683,"compounds":"N-(hexadecanoyl)-sphing-4-enine-1-phosphate(in) <=> N-(hexadecanoyl)-sphing-4-enine-1-phosphate(out)"}
{"X":37570,"RHEA_ID":45684,"compounds":"N-(dodecanoyl)-sphing-4-enine-1-phosphate(in) = N-(dodecanoyl)-sphing-4-enine-1-phosphate(out)"}
{"X":37571,"RHEA_ID":35760,"DIRECTION":"LR","MASTER_ID":35759,"metacyc":"RXN-9497","compounds":"8-O-methylsterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => aflatoxin B1 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":37572,"RHEA_ID":35761,"compounds":"aflatoxin B1 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase] => 8-O-methylsterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}
{"X":37573,"RHEA_ID":45687,"compounds":"N-(dodecanoyl)-sphing-4-enine-1-phosphate(in) <=> N-(dodecanoyl)-sphing-4-enine-1-phosphate(out)"}
{"X":37574,"RHEA_ID":35763,"DIRECTION":"UN","MASTER_ID":35763,"ec":"1.14.14.117","compounds":"8-O-methyldihydrosterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = aflatoxin B2 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":37575,"RHEA_ID":35764,"DIRECTION":"LR","MASTER_ID":35763,"metacyc":"RXN-9502","compounds":"8-O-methyldihydrosterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => aflatoxin B2 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":37576,"RHEA_ID":45690,"compounds":"N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(out) => N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(in)"}
{"X":37577,"RHEA_ID":45691,"compounds":"N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(in) <=> N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(out)"}
{"X":37578,"RHEA_ID":45692,"compounds":"N-(octanoyl)-sphing-4-enine-1-phosphate(in) = N-(octanoyl)-sphing-4-enine-1-phosphate(out)"}
{"X":37579,"RHEA_ID":35768,"DIRECTION":"LR","MASTER_ID":35767,"metacyc":"RXN-9501","compounds":"dihydrosterigmatocystin + S-adenosyl-L-methionine => 8-O-methyldihydrosterigmatocystin + H(+) + S-adenosyl-L-homocysteine"}
{"X":37580,"RHEA_ID":39098,"compounds":"(3S)-hydroxydecanedioyl-CoA + NAD(+) <=> 3-oxodecanedioyl-CoA + H(+) + NADH"}
{"X":37581,"RHEA_ID":45695,"compounds":"N-(octanoyl)-sphing-4-enine-1-phosphate(in) <=> N-(octanoyl)-sphing-4-enine-1-phosphate(out)"}
{"X":37582,"RHEA_ID":45696,"compounds":"N-(acetyl)-sphing-4-enine-1-phosphate(in) = N-(acetyl)-sphing-4-enine-1-phosphate(out)"}
{"X":37583,"RHEA_ID":35772,"DIRECTION":"LR","MASTER_ID":35771,"metacyc":"RXN-9587","compounds":"5-deoxy-5-amino-3-dehydroshikimate => 3-amino-5-hydroxybenzoate + H(+) + H2O"}
{"X":37584,"RHEA_ID":45698,"compounds":"N-(acetyl)-sphing-4-enine-1-phosphate(out) => N-(acetyl)-sphing-4-enine-1-phosphate(in)"}
{"X":37585,"RHEA_ID":45699,"compounds":"N-(acetyl)-sphing-4-enine-1-phosphate(in) <=> N-(acetyl)-sphing-4-enine-1-phosphate(out)"}
{"X":37586,"RHEA_ID":45700,"compounds":"betaine + H2O + O2 = formaldehyde + H2O2 + N,N-dimethylglycine"}
{"X":37587,"RHEA_ID":35776,"DIRECTION":"LR","MASTER_ID":35775,"metacyc":"RXN-9579","compounds":"L-glutamine + UDP-3-oxo-alpha-D-glucose => 2-oxoglutaramate + UDP-alpha-D-kanosamine"}
{"X":37588,"RHEA_ID":45702,"compounds":"formaldehyde + H2O2 + N,N-dimethylglycine => betaine + H2O + O2"}
{"X":37589,"RHEA_ID":35778,"compounds":"L-glutamine + UDP-3-oxo-alpha-D-glucose <=> 2-oxoglutaramate + UDP-alpha-D-kanosamine"}
{"X":37590,"RHEA_ID":35779,"compounds":"all-trans-geranylgeranyl diphosphate = mutildienyl diphosphate"}
{"X":37591,"RHEA_ID":35780,"compounds":"all-trans-geranylgeranyl diphosphate => mutildienyl diphosphate"}
{"X":37592,"RHEA_ID":35781,"compounds":"mutildienyl diphosphate => all-trans-geranylgeranyl diphosphate"}
{"X":37593,"RHEA_ID":35782,"compounds":"all-trans-geranylgeranyl diphosphate <=> mutildienyl diphosphate"}
{"X":37594,"RHEA_ID":35783,"DIRECTION":"UN","MASTER_ID":35783,"ec":"2.4.1.301","compounds":"neamine + UDP-alpha-D-kanosamine = H(+) + kanamycin B + UDP"}
{"X":37595,"RHEA_ID":35784,"DIRECTION":"LR","MASTER_ID":35783,"metacyc":"RXN-13147","compounds":"neamine + UDP-alpha-D-kanosamine => H(+) + kanamycin B + UDP"}
{"X":37596,"RHEA_ID":49012,"compounds":"aurachin C + H(+) + NADH + O2 = aurachin C epoxide + H2O + NAD(+)"}
{"X":37597,"RHEA_ID":45711,"compounds":"3-dehydrocarnitine + acetyl-CoA <=> 3-dehydrocarnityl-CoA + acetate"}
{"X":37598,"RHEA_ID":45712,"compounds":"3-dehydrocarnityl-CoA + CoA = acetyl-CoA + N,N,N-trimethylglycyl-CoA"}
{"X":37599,"RHEA_ID":35788,"DIRECTION":"LR","MASTER_ID":35787,"metacyc":"RXN-13145","compounds":"paromamine + UDP-alpha-D-kanosamine => H(+) + kanamycin C + UDP"}
{"X":37600,"RHEA_ID":45714,"compounds":"acetyl-CoA + N,N,N-trimethylglycyl-CoA => 3-dehydrocarnityl-CoA + CoA"}
{"X":37601,"RHEA_ID":45715,"compounds":"3-dehydrocarnityl-CoA + CoA <=> acetyl-CoA + N,N,N-trimethylglycyl-CoA"}
{"X":37602,"RHEA_ID":45716,"compounds":"H2O + N,N,N-trimethylglycyl-CoA = betaine + CoA + H(+)"}
{"X":37603,"RHEA_ID":35792,"DIRECTION":"LR","MASTER_ID":35791,"metacyc":"RXN-13124","compounds":"2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-kanosamine => H(+) + kanamycin X + UDP"}
{"X":37604,"RHEA_ID":45718,"compounds":"betaine + CoA + H(+) => H2O + N,N,N-trimethylglycyl-CoA"}
{"X":37605,"RHEA_ID":55732,"compounds":"19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] = 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)"}
{"X":37606,"RHEA_ID":35795,"DIRECTION":"UN","MASTER_ID":35795,"ec":"2.4.1.301","compounds":"2'-deamino-2'-hydroxyneamine + UDP-alpha-D-kanosamine = H(+) + kanamycin A + UDP"}
{"X":37607,"RHEA_ID":35796,"DIRECTION":"LR","MASTER_ID":35795,"metacyc":"RXN-13125","compounds":"2'-deamino-2'-hydroxyneamine + UDP-alpha-D-kanosamine => H(+) + kanamycin A + UDP"}
{"X":37608,"RHEA_ID":39126,"compounds":"(2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O <=> (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA"}
{"X":37609,"RHEA_ID":55736,"DIRECTION":"UN","MASTER_ID":55736,"ec":"2.4.1.351","compounds":"alpha-D-galacturonosyl-[(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n) + UDP-beta-L-rhamnose = [(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP"}
{"X":37610,"RHEA_ID":45724,"DIRECTION":"UN","MASTER_ID":45724,"ec":"1.1.1.195","compounds":"(E)-4-coumaroyl alcohol + NADP(+) = (E)-4-coumaraldehyde + H(+) + NADPH"}
{"X":37611,"RHEA_ID":35800,"DIRECTION":"LR","MASTER_ID":35799,"metacyc":"RXN-12356","compounds":"7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O => 7,8-dihydroneopterin 3'-phosphate + H(+)"}
{"X":37612,"RHEA_ID":35801,"compounds":"7,8-dihydroneopterin 3'-phosphate + H(+) => 7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O"}
{"X":37613,"RHEA_ID":55740,"DIRECTION":"UN","MASTER_ID":55740,"ec":"3.2.1.206","compounds":"H2O + oleuropein = D-glucose + oleuropein aglycone"}
{"X":37614,"RHEA_ID":45728,"compounds":"(E)-caffeyl alcohol + NADP(+) = (E)-caffeyl aldehyde + H(+) + NADPH"}
{"X":37615,"RHEA_ID":35804,"DIRECTION":"LR","MASTER_ID":35803,"metacyc":"RXN-12357","compounds":"7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O => 7,8-dihydroneopterin 2'-phosphate + H(+)"}
{"X":37616,"RHEA_ID":35805,"compounds":"7,8-dihydroneopterin 2'-phosphate + H(+) => 7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O"}
{"X":37617,"RHEA_ID":49033,"DIRECTION":"LR","MASTER_ID":49032,"metacyc":"RXN-17350","compounds":"(-)-4'-desmethyl-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase] => 4'-demethylepipodophyllotoxin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":37618,"RHEA_ID":45732,"DIRECTION":"UN","MASTER_ID":45732,"ec":"4.1.99.24","compounds":"D-ribulose 5-phosphate + L-tyrosine = (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate"}
{"X":37619,"RHEA_ID":35808,"DIRECTION":"LR","MASTER_ID":35807,"metacyc":"RXN-8777","compounds":"2-dehydro-3-deoxy-D-arabinonate => 2,5-dioxopentanoate + H2O"}
{"X":37620,"RHEA_ID":35809,"compounds":"2,5-dioxopentanoate + H2O => 2-dehydro-3-deoxy-D-arabinonate"}
{"X":37621,"RHEA_ID":55748,"DIRECTION":"UN","MASTER_ID":55748,"ec":"1.8.98.5","compounds":"coenzyme B + coenzyme M + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = coenzyme M-coenzyme B heterodisulfide + 2 H2 + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":37622,"RHEA_ID":45736,"compounds":"(3E)-hexenoyl-CoA = (2E)-hexenoyl-CoA"}
{"X":37623,"RHEA_ID":35812,"DIRECTION":"LR","MASTER_ID":35811,"metacyc":"RXN-3602","compounds":"(3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol => (-)-medicarpin + H2O"}
{"X":37624,"RHEA_ID":35813,"compounds":"(-)-medicarpin + H2O => (3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol"}
{"X":37625,"RHEA_ID":55752,"DIRECTION":"UN","MASTER_ID":55752,"ec":"1.8.98.6","compounds":"2 CO2 + coenzyme B + coenzyme M + 2 reduced [2Fe-2S]-[ferredoxin] = coenzyme M-coenzyme B heterodisulfide + 2 formate + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":37626,"RHEA_ID":45740,"DIRECTION":"UN","MASTER_ID":45740,"ec":"1.14.11.55","compounds":"2-oxoglutarate + L-ectoine + O2 = 5-hydroxyectoine + CO2 + succinate"}
{"X":37627,"RHEA_ID":35816,"DIRECTION":"LR","MASTER_ID":35815,"metacyc":"RXN-8124","compounds":"4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) => 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate"}
{"X":37628,"RHEA_ID":35817,"compounds":"4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate => 4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+)"}
{"X":37629,"RHEA_ID":35818,"compounds":"4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) <=> 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate"}
{"X":37630,"RHEA_ID":45744,"compounds":"(6S)-5,6,7,8-tetrahydropteroate + NAD(+) = 7,8-dihydropteroate + H(+) + NADH"}
{"X":37631,"RHEA_ID":35820,"compounds":"5,6,7,8-tetrahydromethanopterin + NADP(+) => 7,8-dihydromethanopterin + H(+) + NADPH"}
{"X":37632,"RHEA_ID":35821,"compounds":"7,8-dihydromethanopterin + H(+) + NADPH => 5,6,7,8-tetrahydromethanopterin + NADP(+)"}
{"X":37633,"RHEA_ID":55760,"DIRECTION":"UN","MASTER_ID":55760,"ec":"2.3.1.270","compounds":"a fatty acyl-[ACP] + a lyso-ornithine lipid = an N(2)-[(3R)-3-(acyloxy)acyl]-L-ornithine lipid + holo-[ACP]"}
{"X":37634,"RHEA_ID":45748,"compounds":"(3Z)-hexenoyl-CoA = (2E)-hexenoyl-CoA"}
{"X":37635,"RHEA_ID":35824,"compounds":"5,6,7,8-tetrahydromethanopterin + NAD(+) => 7,8-dihydromethanopterin + H(+) + NADH"}
{"X":37636,"RHEA_ID":35825,"DIRECTION":"RL","MASTER_ID":35823,"metacyc":"RXN-10029","compounds":"7,8-dihydromethanopterin + H(+) + NADH => 5,6,7,8-tetrahydromethanopterin + NAD(+)"}
{"X":37637,"RHEA_ID":55764,"DIRECTION":"UN","MASTER_ID":55764,"ec":"3.3.2.9","compounds":"1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O = 2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol"}
{"X":37638,"RHEA_ID":45752,"compounds":"(3E)-decenoyl-CoA = (2E)-decenoyl-CoA"}
{"X":37639,"RHEA_ID":35828,"DIRECTION":"LR","MASTER_ID":35827,"metacyc":"RXN-12515","compounds":"H2O + N(1)-aminopropylagmatine => spermidine + urea"}
{"X":37640,"RHEA_ID":35829,"compounds":"spermidine + urea => H2O + N(1)-aminopropylagmatine"}
{"X":37641,"RHEA_ID":55768,"compounds":"all-trans-retinoate + UDP-alpha-D-glucuronate = all-trans-retinoyl-1-O-(beta-D-glucuronate) + UDP"}
{"X":37642,"RHEA_ID":45756,"compounds":"(6S)-5,6,7,8-tetrahydrofolate + N,N-dimethylglycine + O2 = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O2 + sarcosine"}
{"X":37643,"RHEA_ID":35832,"DIRECTION":"LR","MASTER_ID":35831,"metacyc":"RXN-14401","compounds":"2-oxoglutarate + kanamycin B + O2 => 2'-dehydrokanamycin A + CO2 + NH4(+) + succinate"}
{"X":37644,"RHEA_ID":35833,"compounds":"2'-dehydrokanamycin A + CO2 + NH4(+) + succinate => 2-oxoglutarate + kanamycin B + O2"}
{"X":37645,"RHEA_ID":45759,"compounds":"(6S)-5,6,7,8-tetrahydrofolate + N,N-dimethylglycine + O2 <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O2 + sarcosine"}
{"X":37646,"RHEA_ID":45760,"compounds":"dTDP-beta-L-daunosamine + epsilon-rhodomycinone = dTDP + H(+) + rhodomycin D"}
{"X":37647,"RHEA_ID":35836,"DIRECTION":"LR","MASTER_ID":35835,"metacyc":"RXN-14402","compounds":"2'-dehydrokanamycin A + H(+) + NADPH => kanamycin A + NADP(+)"}
{"X":37648,"RHEA_ID":35837,"compounds":"kanamycin A + NADP(+) => 2'-dehydrokanamycin A + H(+) + NADPH"}
{"X":37649,"RHEA_ID":55776,"compounds":"all-trans-4-hydroxyretinoate + UDP-alpha-D-glucuronate = 4-hydroxy-4-O-(beta-D-glucuronide)-all-trans-retinoate + H(+) + UDP"}
{"X":37650,"RHEA_ID":55777,"compounds":"all-trans-4-hydroxyretinoate + UDP-alpha-D-glucuronate => 4-hydroxy-4-O-(beta-D-glucuronide)-all-trans-retinoate + H(+) + UDP"}
{"X":37651,"RHEA_ID":35840,"compounds":"1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA => a cardiolipin + CoA"}
{"X":37652,"RHEA_ID":35841,"compounds":"a cardiolipin + CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA"}
{"X":37653,"RHEA_ID":35842,"compounds":"1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA <=> a cardiolipin + CoA"}
{"X":37654,"RHEA_ID":55781,"compounds":"all-trans-5,6-epoxyretinoate + UDP-alpha-D-glucuronate => all-trans-5,6-epoxyretinoyl-1-O-(beta-D-glucuronate) + UDP"}
{"X":37655,"RHEA_ID":35844,"compounds":"1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1-acyl-sn-glycero-3-phosphoethanolamine + a cardiolipin"}
{"X":37656,"RHEA_ID":35845,"compounds":"a 1-acyl-sn-glycero-3-phosphoethanolamine + a cardiolipin => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine"}
{"X":37657,"RHEA_ID":35846,"compounds":"1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a 1-acyl-sn-glycero-3-phosphoethanolamine + a cardiolipin"}
{"X":37658,"RHEA_ID":45772,"DIRECTION":"UN","MASTER_ID":45772,"ec":"2.4.1.319","compounds":"[(1->4)-beta-D-mannosyl](n) + phosphate = [(1->4)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate"}
{"X":37659,"RHEA_ID":35848,"DIRECTION":"LR","MASTER_ID":35847,"metacyc":"RXN3DJ-11417","compounds":"ATP + sphing-4-enine => ADP + H(+) + sphing-4-enine 1-phosphate"}
{"X":37660,"RHEA_ID":35849,"compounds":"ADP + H(+) + sphing-4-enine 1-phosphate => ATP + sphing-4-enine"}
{"X":37661,"RHEA_ID":45775,"DIRECTION":"BI","MASTER_ID":45772,"metacyc":"RXN-15202","compounds":"[(1->4)-beta-D-mannosyl](n) + phosphate <=> [(1->4)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate"}
{"X":37662,"RHEA_ID":45776,"DIRECTION":"UN","MASTER_ID":45776,"ec":"3.5.5.1","compounds":"(indol-3-yl)acetonitrile + 2 H2O = (indol-3-yl)acetate + NH4(+)"}
{"X":37663,"RHEA_ID":45777,"DIRECTION":"LR","MASTER_ID":45776,"metacyc":"RXN-1404","compounds":"(indol-3-yl)acetonitrile + 2 H2O => (indol-3-yl)acetate + NH4(+)"}
{"X":37664,"RHEA_ID":35853,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA"}
{"X":37665,"RHEA_ID":35854,"compounds":"1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":37666,"RHEA_ID":45780,"compounds":"(9Z)-octadecenoyl-CoA + di-(9Z)-octadecenoylglycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA"}
{"X":37667,"RHEA_ID":45781,"compounds":"(9Z)-octadecenoyl-CoA + di-(9Z)-octadecenoylglycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA"}
{"X":37668,"RHEA_ID":35857,"compounds":"1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA"}
{"X":37669,"RHEA_ID":35858,"compounds":"1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA <=> 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":37670,"RHEA_ID":35859,"compounds":"1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":37671,"RHEA_ID":45785,"DIRECTION":"LR","MASTER_ID":45784,"metacyc":"RXN-18229","compounds":"2 H2O + phenylpropanonitrile => 3-phenylpropanoate + NH4(+)"}
{"X":37672,"RHEA_ID":35861,"compounds":"1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA"}
{"X":37673,"RHEA_ID":35862,"compounds":"1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA <=> 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":37674,"RHEA_ID":35863,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":37675,"RHEA_ID":35864,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":37676,"RHEA_ID":35865,"compounds":"1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA"}
{"X":37677,"RHEA_ID":45791,"compounds":"(9Z)-hexadecenoyl-CoA + 1,2-dihexadecanoyl-sn-glycerol <=> 1,2-dihexadecanoyl-3-(9Z-hexadecenoyl)-sn-glycerol + CoA"}
{"X":37678,"RHEA_ID":35867,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-D-myo-inositol + CoA"}
{"X":37679,"RHEA_ID":35868,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-D-myo-inositol + CoA"}
{"X":37680,"RHEA_ID":35869,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-D-myo-inositol + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)"}
{"X":37681,"RHEA_ID":45795,"compounds":"2-oxoglutarate + [ribosomal protein S23]-L-proline + O2 <=> [ribosomal protein S23]-trans-3-hydroxy-L-proline + CO2 + succinate"}
{"X":37682,"RHEA_ID":35871,"compounds":"1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}
{"X":37683,"RHEA_ID":35872,"compounds":"1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + hexadecanoyl-CoA => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}
{"X":37684,"RHEA_ID":39202,"compounds":"(3R)-hydroxytetracosanoyl-CoA <=> (2E)-tetracosenoyl-CoA + H2O"}
{"X":37685,"RHEA_ID":35874,"compounds":"1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + hexadecanoyl-CoA <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}
{"X":37686,"RHEA_ID":35875,"compounds":"1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}
{"X":37687,"RHEA_ID":35876,"compounds":"1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}
{"X":37688,"RHEA_ID":49104,"compounds":"Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine = 5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester"}
{"X":37689,"RHEA_ID":55816,"compounds":"a bacteriochlorophyllide d + H2O + S-adenosyl-L-methionine = 5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide d + H(+) + L-methionine"}
{"X":37690,"RHEA_ID":35879,"compounds":"(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}
{"X":37691,"RHEA_ID":35880,"compounds":"(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}
{"X":37692,"RHEA_ID":35881,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)"}
{"X":37693,"RHEA_ID":55820,"compounds":"a 7(1)-hydroxybacteriochlorophyllide d + H2O + S-adenosyl-L-methionine = 5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide d + H(+) + L-methionine"}
{"X":37694,"RHEA_ID":35883,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}
{"X":37695,"RHEA_ID":35884,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}
{"X":37696,"RHEA_ID":35885,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)"}
{"X":37697,"RHEA_ID":35886,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}
{"X":37698,"RHEA_ID":35887,"compounds":"1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":37699,"RHEA_ID":35888,"compounds":"1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + octadecanoyl-CoA => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":37700,"RHEA_ID":35889,"compounds":"1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + octadecanoyl-CoA"}
{"X":37701,"RHEA_ID":55828,"compounds":"cortisol + O2 + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":37702,"RHEA_ID":35891,"compounds":"(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":37703,"RHEA_ID":35892,"compounds":"(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":37704,"RHEA_ID":35893,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)"}
{"X":37705,"RHEA_ID":45819,"compounds":"(S)-lactate + A <=> AH2 + pyruvate"}
{"X":37706,"RHEA_ID":45820,"compounds":"mesaconate + succinyl-CoA = 2-methylfumaryl-CoA + succinate"}
{"X":37707,"RHEA_ID":35896,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":37708,"RHEA_ID":39226,"compounds":"(3R)-hydroxyoctacosanoyl-CoA <=> (2E)-octacosenoyl-CoA + H2O"}
{"X":37709,"RHEA_ID":45823,"compounds":"mesaconate + succinyl-CoA <=> 2-methylfumaryl-CoA + succinate"}
{"X":37710,"RHEA_ID":45824,"compounds":"H(+) + L-serine = CO2 + ethanolamine"}
{"X":37711,"RHEA_ID":35900,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA => 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":37712,"RHEA_ID":35901,"compounds":"1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA => 1-hexadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA"}
{"X":37713,"RHEA_ID":35902,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA <=> 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":37714,"RHEA_ID":45828,"compounds":"(3R)-hydroxyhexanoyl-CoA + NAD(+) = 3-oxohexanoyl-CoA + H(+) + NADH"}
{"X":37715,"RHEA_ID":39233,"compounds":"(3R)-hydroxytriacontanoyl-CoA + NADP(+) => 3-oxo-triacontanoyl-CoA + H(+) + NADPH"}
{"X":37716,"RHEA_ID":49132,"compounds":"an adenosine in tRNA + S-adenosyl-L-methionine = an N(1)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":37717,"RHEA_ID":35906,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":37718,"RHEA_ID":45832,"compounds":"(3R)-hydroxydecanoyl-CoA + NAD(+) = 3-oxodecanoyl-CoA + H(+) + NADH"}
{"X":37719,"RHEA_ID":35908,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":37720,"RHEA_ID":35909,"compounds":"1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA => 1-hexadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA"}
{"X":37721,"RHEA_ID":35910,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA <=> 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":37722,"RHEA_ID":45836,"compounds":"1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-4-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}
{"X":37723,"RHEA_ID":35912,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA"}
{"X":37724,"RHEA_ID":49140,"DIRECTION":"UN","MASTER_ID":49140,"ec":"4.2.1.164","compounds":"dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":37725,"RHEA_ID":35914,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA"}
{"X":37726,"RHEA_ID":45840,"compounds":"(3R)-hydroxydecanoyl-CoA + NADP(+) = 3-oxodecanoyl-CoA + H(+) + NADPH"}
{"X":37727,"RHEA_ID":35916,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":37728,"RHEA_ID":35917,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate"}
{"X":37729,"RHEA_ID":35918,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":37730,"RHEA_ID":35919,"compounds":"2'-deamino-2'-hydroxyneamine + UDP-alpha-D-glucose = H(+) + kanamycin D + UDP"}
{"X":37731,"RHEA_ID":35920,"DIRECTION":"LR","MASTER_ID":35919,"metacyc":"RXN-13148","compounds":"2'-deamino-2'-hydroxyneamine + UDP-alpha-D-glucose => H(+) + kanamycin D + UDP"}
{"X":37732,"RHEA_ID":35921,"compounds":"H(+) + kanamycin D + UDP => 2'-deamino-2'-hydroxyneamine + UDP-alpha-D-glucose"}
{"X":37733,"RHEA_ID":35922,"compounds":"2'-deamino-2'-hydroxyneamine + UDP-alpha-D-glucose <=> H(+) + kanamycin D + UDP"}
{"X":37734,"RHEA_ID":35923,"compounds":"neamine + UDP-alpha-D-glucose = 3''-deamino-3''-hydroxykanamycin B + H(+) + UDP"}
{"X":37735,"RHEA_ID":35924,"DIRECTION":"LR","MASTER_ID":35923,"metacyc":"RXN-13149","compounds":"neamine + UDP-alpha-D-glucose => 3''-deamino-3''-hydroxykanamycin B + H(+) + UDP"}
{"X":37736,"RHEA_ID":35925,"compounds":"3''-deamino-3''-hydroxykanamycin B + H(+) + UDP => neamine + UDP-alpha-D-glucose"}
{"X":37737,"RHEA_ID":35926,"compounds":"neamine + UDP-alpha-D-glucose <=> 3''-deamino-3''-hydroxykanamycin B + H(+) + UDP"}
{"X":37738,"RHEA_ID":45852,"compounds":"Co(II)-factor III + H(+) + S-adenosyl-L-methionine = Co(II)-factor IV + S-adenosyl-L-homocysteine"}
{"X":37739,"RHEA_ID":35928,"DIRECTION":"LR","MASTER_ID":35927,"metacyc":"RXN-13164","compounds":"paromamine + UDP-alpha-D-glucose => 3''-deamino-3''-hydroxykanamycin C + H(+) + UDP"}
{"X":37740,"RHEA_ID":35929,"compounds":"3''-deamino-3''-hydroxykanamycin C + H(+) + UDP => paromamine + UDP-alpha-D-glucose"}
{"X":37741,"RHEA_ID":45855,"compounds":"Co(II)-factor III + H(+) + S-adenosyl-L-methionine <=> Co(II)-factor IV + S-adenosyl-L-homocysteine"}
{"X":37742,"RHEA_ID":45856,"compounds":"3-hydroxytetradecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(2-hydroxytridecyl)-pyran-2-one + 2 CO2 + 3 CoA"}
{"X":37743,"RHEA_ID":35932,"compounds":"2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-glucose => 3''-deamino-3''-hydroxykanamycin X + H(+) + UDP"}
{"X":37744,"RHEA_ID":35933,"compounds":"3''-deamino-3''-hydroxykanamycin X + H(+) + UDP => 2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-glucose"}
{"X":37745,"RHEA_ID":45859,"compounds":"3-hydroxytetradecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(2-hydroxytridecyl)-pyran-2-one + 2 CO2 + 3 CoA"}
{"X":37746,"RHEA_ID":45860,"compounds":"12-hydroxyoctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(11-hydroxyheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA"}
{"X":37747,"RHEA_ID":35936,"compounds":"2 ATP + L-proline + L-tryptophan => 2 AMP + brevianamide F + 2 diphosphate + 2 H(+)"}
{"X":37748,"RHEA_ID":35937,"compounds":"2 AMP + brevianamide F + 2 diphosphate + 2 H(+) => 2 ATP + L-proline + L-tryptophan"}
{"X":37749,"RHEA_ID":45863,"compounds":"12-hydroxyoctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(11-hydroxyheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA"}
{"X":37750,"RHEA_ID":35939,"DIRECTION":"UN","MASTER_ID":35939,"ec":"2.5.1.106","compounds":"brevianamide F + dimethylallyl diphosphate = diphosphate + tryprostatin B"}
{"X":37751,"RHEA_ID":35940,"DIRECTION":"LR","MASTER_ID":35939,"metacyc":"RXN-14418","compounds":"brevianamide F + dimethylallyl diphosphate => diphosphate + tryprostatin B"}
{"X":37752,"RHEA_ID":45866,"compounds":"4-hydroxy-6-(15-hydroxypentadecyl)-pyran-2-one + 2 CO2 + 3 CoA => 16-hydroxyhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA"}
{"X":37753,"RHEA_ID":55884,"compounds":"[aequorin] + 3 Ca(2+) = [aequorin]--dioxetanone"}
{"X":37754,"RHEA_ID":35943,"DIRECTION":"UN","MASTER_ID":35943,"ec":"2.5.1.109","compounds":"brevianamide F + dimethylallyl diphosphate = deoxybrevianamide E + diphosphate"}
{"X":37755,"RHEA_ID":35944,"DIRECTION":"LR","MASTER_ID":35943,"metacyc":"RXN-14419","compounds":"brevianamide F + dimethylallyl diphosphate => deoxybrevianamide E + diphosphate"}
{"X":37756,"RHEA_ID":49172,"DIRECTION":"UN","MASTER_ID":49172,"ec":"2.1.1.332","compounds":"8,12-diethyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine = 12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine"}
{"X":37757,"RHEA_ID":45871,"compounds":"9-decenoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(non-8-en-1-yl)-pyran-2-one + 2 CO2 + 3 CoA"}
{"X":37758,"RHEA_ID":35947,"DIRECTION":"UN","MASTER_ID":35947,"ec":"1.3.1.100","compounds":"dihydrochanoclavine-I aldehyde + NADP(+) = chanoclavine-I aldehyde + H(+) + NADPH"}
{"X":37759,"RHEA_ID":35948,"compounds":"dihydrochanoclavine-I aldehyde + NADP(+) => chanoclavine-I aldehyde + H(+) + NADPH"}
{"X":37760,"RHEA_ID":39278,"compounds":"(2E,15Z)-tetracosadienoyl-CoA + H(+) + NADPH <=> (15Z)-tetracosenoyl-CoA + NADP(+)"}
{"X":37761,"RHEA_ID":35950,"compounds":"dihydrochanoclavine-I aldehyde + NADP(+) <=> chanoclavine-I aldehyde + H(+) + NADPH"}
{"X":37762,"RHEA_ID":35951,"DIRECTION":"UN","MASTER_ID":35951,"ec":"2.5.1.105","compounds":"(7,8-dihydropterin-6-yl)methyl diphosphate + 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate = diphosphate + N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate"}
{"X":37763,"RHEA_ID":35952,"DIRECTION":"LR","MASTER_ID":35951,"metacyc":"RXN-10009","compounds":"(7,8-dihydropterin-6-yl)methyl diphosphate + 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate => diphosphate + N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate"}
{"X":37764,"RHEA_ID":45878,"compounds":"6-(hexadecan-2-yl)-4-hydroxy-pyran-2-one + 2 CO2 + 3 CoA => 2-methylhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA"}
{"X":37765,"RHEA_ID":55896,"DIRECTION":"UN","MASTER_ID":55896,"ec":"1.14.19.58","compounds":"chloride + FADH2 + L-tryptophan + O2 = 5-chloro-L-tryptophan + FAD + 2 H2O"}
{"X":37766,"RHEA_ID":35955,"DIRECTION":"UN","MASTER_ID":35955,"ec":"1.14.14.118","compounds":"O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin B = 6-hydroxytryprostatin B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":37767,"RHEA_ID":35956,"DIRECTION":"LR","MASTER_ID":35955,"metacyc":"RXN-14413","compounds":"O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin B => 6-hydroxytryprostatin B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":37768,"RHEA_ID":45882,"compounds":"4-hydroxy-6-(2-methyldecyl)-pyran-2-one + 2 CO2 + 3 CoA => 3-methylundecanoyl-CoA + 2 H(+) + 2 malonyl-CoA"}
{"X":37769,"RHEA_ID":55900,"DIRECTION":"UN","MASTER_ID":55900,"ec":"1.14.19.59","compounds":"chloride + FADH2 + L-tryptophan + O2 = 6-chloro-L-tryptophan + FAD + 2 H2O"}
{"X":37770,"RHEA_ID":35959,"compounds":"H(+) + NADPH + O2 + tryprostatin B = demethoxyfumitremorgin C + 2 H2O + NADP(+)"}
{"X":37771,"RHEA_ID":35960,"compounds":"H(+) + NADPH + O2 + tryprostatin B => demethoxyfumitremorgin C + 2 H2O + NADP(+)"}
{"X":37772,"RHEA_ID":45886,"compounds":"4-hydroxy-6-(11-methylheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA => 12-methyloctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA"}
{"X":37773,"RHEA_ID":45887,"compounds":"12-methyloctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(11-methylheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA"}
{"X":37774,"RHEA_ID":35963,"DIRECTION":"UN","MASTER_ID":35963,"ec":"1.14.19.71","compounds":"O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin A = fumitremorgin C + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":37775,"RHEA_ID":35964,"DIRECTION":"LR","MASTER_ID":35963,"metacyc":"RXN-14415","compounds":"O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin A => fumitremorgin C + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":37776,"RHEA_ID":39294,"compounds":"(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + CO2 + CoA"}
{"X":37777,"RHEA_ID":55920,"DIRECTION":"UN","MASTER_ID":55920,"ec":"1.13.11.85","compounds":"[cis-1,4-isoprene](n) + O2 = (4Z,8Z)-4,8-dimethyl-12-oxotrideca-4,8-dienal + cis-1,4-isoprene(n-3)"}
{"X":37778,"RHEA_ID":35967,"DIRECTION":"UN","MASTER_ID":35967,"ec":"1.14.14.119","compounds":"fumitremorgin C + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 12alpha,13alpha-dihydroxyfumitremorgin C + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":37779,"RHEA_ID":35968,"DIRECTION":"LR","MASTER_ID":35967,"metacyc":"RXN-14414","compounds":"fumitremorgin C + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 12alpha,13alpha-dihydroxyfumitremorgin C + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":37780,"RHEA_ID":45894,"compounds":"CMP + H(+) + N-acylsphing-4-enine 1-phosphoethanolamine => an N-acylsphing-4-enine + CDP-ethanolamine"}
{"X":37781,"RHEA_ID":45895,"compounds":"an N-acylsphing-4-enine + CDP-ethanolamine <=> CMP + H(+) + N-acylsphing-4-enine 1-phosphoethanolamine"}
{"X":37782,"RHEA_ID":35971,"DIRECTION":"UN","MASTER_ID":35971,"ec":"2.5.1.110","compounds":"12alpha,13alpha-dihydroxyfumitremorgin C + dimethylallyl diphosphate = diphosphate + fumitremorgin B"}
{"X":37783,"RHEA_ID":35972,"DIRECTION":"LR","MASTER_ID":35971,"metacyc":"RXN-14420","compounds":"12alpha,13alpha-dihydroxyfumitremorgin C + dimethylallyl diphosphate => diphosphate + fumitremorgin B"}
{"X":37784,"RHEA_ID":35973,"compounds":"diphosphate + fumitremorgin B => 12alpha,13alpha-dihydroxyfumitremorgin C + dimethylallyl diphosphate"}
{"X":37785,"RHEA_ID":45899,"compounds":"CDP-ethanolamine + N-acyl-sphingoid base <=> CMP + H(+) + N-(acyl)-sphingoid 1-phosphoethanolamine"}
{"X":37786,"RHEA_ID":35975,"DIRECTION":"UN","MASTER_ID":35975,"ec":"1.14.11.38","compounds":"2-oxoglutarate + AH2 + fumitremorgin B + 2 O2 = A + CO2 + H2O + succinate + verruculogen"}
{"X":37787,"RHEA_ID":35976,"DIRECTION":"LR","MASTER_ID":35975,"metacyc":"RXN-14407","compounds":"2-oxoglutarate + AH2 + fumitremorgin B + 2 O2 => A + CO2 + H2O + succinate + verruculogen"}
{"X":37788,"RHEA_ID":45902,"compounds":"a 4-saturated (2E)-enoyl-CoA => a (3Z)-enoyl-CoA"}
{"X":37789,"RHEA_ID":45903,"DIRECTION":"BI","MASTER_ID":45900,"metacyc":"ENOYL-COA-DELTA-ISOM-RXN","compounds":"a (3Z)-enoyl-CoA <=> a 4-saturated (2E)-enoyl-CoA"}
{"X":37790,"RHEA_ID":35979,"DIRECTION":"UN","MASTER_ID":35979,"ec":"2.5.1.107","compounds":"dimethylallyl diphosphate + verruculogen = diphosphate + fumitremorgin A"}
{"X":37791,"RHEA_ID":35980,"DIRECTION":"LR","MASTER_ID":35979,"metacyc":"RXN-14421","compounds":"dimethylallyl diphosphate + verruculogen => diphosphate + fumitremorgin A"}
{"X":37792,"RHEA_ID":45906,"compounds":"dTDP + epivancomycin + H(+) => devancoaminyl-vancomycin + dTDP-beta-L-vancosamine"}
{"X":37793,"RHEA_ID":55936,"compounds":"all-trans-4-hydroxyretinol + NAD(+) = all-trans-4-hydroxyretinal + H(+) + NADH"}
{"X":37794,"RHEA_ID":35983,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":37795,"RHEA_ID":35984,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":37796,"RHEA_ID":45910,"compounds":"chloroeremomycin + dTDP + H(+) => chloroorienticin B + dTDP-beta-L-vancosamine"}
{"X":37797,"RHEA_ID":45911,"compounds":"chloroorienticin B + dTDP-beta-L-vancosamine <=> chloroeremomycin + dTDP + H(+)"}
{"X":37798,"RHEA_ID":35987,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":37799,"RHEA_ID":35988,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":37800,"RHEA_ID":35989,"compounds":"1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA"}
{"X":37801,"RHEA_ID":45915,"compounds":"a (2E,4E)-dienoyl-CoA + H(+) + NADPH <=> a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)"}
{"X":37802,"RHEA_ID":35991,"compounds":"(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":37803,"RHEA_ID":35992,"compounds":"(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":37804,"RHEA_ID":45918,"compounds":"4-hydroxy-6-(13-hydroxy-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA => 12-hydroxyoctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA"}
{"X":37805,"RHEA_ID":45919,"compounds":"12-hydroxyoctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(13-hydroxy-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA"}
{"X":37806,"RHEA_ID":35995,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":37807,"RHEA_ID":35996,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":37808,"RHEA_ID":49224,"compounds":"dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + reduced [flavodoxin] = dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H(+) + H2O + oxidized [flavodoxin]"}
{"X":37809,"RHEA_ID":35998,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":37810,"RHEA_ID":35999,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":37811,"RHEA_ID":36000,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":37812,"RHEA_ID":45926,"compounds":"4-hydroxy-6-(2-oxoundec-10-en-1-yl)pyran-2-one + 3 CO2 + 4 CoA => 9-decenoyl-CoA + 3 H(+) + 3 malonyl-CoA"}
{"X":37813,"RHEA_ID":36002,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":37814,"RHEA_ID":45928,"compounds":"15-hydroxypentadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(16-hydroxy-2-oxohexadecyl)pyran-2-one + 3 CO2 + 4 CoA"}
{"X":37815,"RHEA_ID":36004,"compounds":"(S)-4-hydroxy-2-oxohexanoate => propanal + pyruvate"}
{"X":37816,"RHEA_ID":45930,"compounds":"4-hydroxy-6-(16-hydroxy-2-oxohexadecyl)pyran-2-one + 3 CO2 + 4 CoA => 15-hydroxypentadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA"}
{"X":37817,"RHEA_ID":36007,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":37818,"RHEA_ID":36008,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA => 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":37819,"RHEA_ID":45934,"compounds":"4-hydroxy-6-(3-methyl-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA => 2-methylhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA"}
{"X":37820,"RHEA_ID":36010,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":37821,"RHEA_ID":36011,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":37822,"RHEA_ID":36012,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":37823,"RHEA_ID":45938,"compounds":"4-hydroxy-6-(4-methyl-2-oxododecyl)pyran-2-one + 3 CO2 + 4 CoA => 3-methylundecanoyl-CoA + 3 H(+) + 3 malonyl-CoA"}
{"X":37824,"RHEA_ID":36014,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA <=> 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":37825,"RHEA_ID":45940,"compounds":"12-methyloctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(13-methyl-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA"}
{"X":37826,"RHEA_ID":36016,"compounds":"(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":37827,"RHEA_ID":39346,"compounds":"(3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA <=> (2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H2O"}
{"X":37828,"RHEA_ID":36018,"compounds":"(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":37829,"RHEA_ID":36019,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":37830,"RHEA_ID":36020,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":37831,"RHEA_ID":45946,"compounds":"4-hydroxy-6-(13-methyl-2-oxotetradecyl)pyran-2-one + 3 CO2 + 4 CoA => 12-methyltridecanoyl-CoA + 3 H(+) + 3 malonyl-CoA"}
{"X":37832,"RHEA_ID":45947,"compounds":"12-methyltridecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(13-methyl-2-oxotetradecyl)pyran-2-one + 3 CO2 + 4 CoA"}
{"X":37833,"RHEA_ID":36023,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":37834,"RHEA_ID":45949,"DIRECTION":"LR","MASTER_ID":45948,"ecocyc":"RXN0-7160","metacyc":"RXN0-7160","compounds":"acetyl-CoA + L-lysyl-[protein] => CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]"}
{"X":37835,"RHEA_ID":36025,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":37836,"RHEA_ID":36026,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":37837,"RHEA_ID":36027,"DIRECTION":"UN","MASTER_ID":36027,"ec":"1.2.1.87","compounds":"CoA + NAD(+) + propanal = H(+) + NADH + propanoyl-CoA"}
{"X":37838,"RHEA_ID":36028,"compounds":"CoA + NAD(+) + propanal => H(+) + NADH + propanoyl-CoA"}
{"X":37839,"RHEA_ID":36029,"compounds":"H(+) + NADH + propanoyl-CoA => CoA + NAD(+) + propanal"}
{"X":37840,"RHEA_ID":55984,"DIRECTION":"UN","MASTER_ID":55984,"ec":"2.4.1.354","compounds":"(R)-mandelonitrile + UDP-alpha-D-glucose = (R)-prunasin + H(+) + UDP"}
{"X":37841,"RHEA_ID":36035,"DIRECTION":"UN","MASTER_ID":36035,"ec":"1.3.1.101","compounds":"2,3-bis-(O-phytanyl)-sn-glycerol 1-phosphate + 8 NADP(+) = 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADPH"}
{"X":37842,"RHEA_ID":36036,"compounds":"2,3-bis-(O-phytanyl)-sn-glycerol 1-phosphate + 8 NADP(+) => 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADPH"}
{"X":37843,"RHEA_ID":36037,"DIRECTION":"RL","MASTER_ID":36035,"metacyc":"RXN-14398","compounds":"2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADPH => 2,3-bis-(O-phytanyl)-sn-glycerol 1-phosphate + 8 NADP(+)"}
{"X":37844,"RHEA_ID":55988,"DIRECTION":"UN","MASTER_ID":55988,"ec":"3.2.1.106","compounds":"H2O + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] = beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein]"}
{"X":37845,"RHEA_ID":36039,"DIRECTION":"UN","MASTER_ID":36039,"ec":"1.3.1.101","compounds":"2,3-bis-(O-phytanyl)-sn-glycerol 1-phosphate + 8 NAD(+) = 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADH"}
{"X":37846,"RHEA_ID":36040,"compounds":"2,3-bis-(O-phytanyl)-sn-glycerol 1-phosphate + 8 NAD(+) => 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADH"}
{"X":37847,"RHEA_ID":36041,"DIRECTION":"RL","MASTER_ID":36039,"metacyc":"RXN-14398","compounds":"2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADH => 2,3-bis-(O-phytanyl)-sn-glycerol 1-phosphate + 8 NAD(+)"}
{"X":37848,"RHEA_ID":45963,"compounds":"24,25-dihydrolanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}
{"X":37849,"RHEA_ID":36043,"DIRECTION":"UN","MASTER_ID":36043,"ec":"1.13.11.82","compounds":"all-trans-8'-apo-beta-carotenal + O2 = 13-apo-beta-carotenone + 2,6-dimethyldeca-2,4,6,8-tetraenedial"}
{"X":37850,"RHEA_ID":45965,"compounds":"5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 H2O => 2 AMP + ATP + 2 H(+)"}
{"X":37851,"RHEA_ID":36045,"compounds":"13-apo-beta-carotenone + 2,6-dimethyldeca-2,4,6,8-tetraenedial => all-trans-8'-apo-beta-carotenal + O2"}
{"X":37852,"RHEA_ID":55996,"DIRECTION":"UN","MASTER_ID":55996,"ec":"3.2.1.207","compounds":"H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] = beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein]"}
{"X":37853,"RHEA_ID":36047,"DIRECTION":"UN","MASTER_ID":36047,"ec":"1.2.99.8","compounds":"A + D-glyceraldehyde + H2O = (R)-glycerate + AH2 + H(+)"}
{"X":37854,"RHEA_ID":45969,"compounds":"androst-4-ene-3,17-dione + H(+) + NADH + O2 => 9alpha-hydroxy-androst-4-ene-3,17-dione + H2O + NAD(+)"}
{"X":37855,"RHEA_ID":36049,"compounds":"(R)-glycerate + AH2 + H(+) => A + D-glyceraldehyde + H2O"}
{"X":37856,"RHEA_ID":36051,"DIRECTION":"UN","MASTER_ID":36051,"ec":"3.2.1.185","compounds":"beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose + H2O = 2 beta-L-arabinofuranose"}
{"X":37857,"RHEA_ID":45973,"compounds":"3-oxochol-4-en-22-oate + H(+) + NADH + O2 => 9alpha-hydroxy-3-oxochol-4-en-22-oate + H2O + NAD(+)"}
{"X":37858,"RHEA_ID":36053,"compounds":"2 beta-L-arabinofuranose => beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose + H2O"}
{"X":37859,"RHEA_ID":56004,"DIRECTION":"UN","MASTER_ID":56004,"ec":"3.2.1.209","compounds":"H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) = beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3)"}
{"X":37860,"RHEA_ID":36055,"DIRECTION":"UN","MASTER_ID":36055,"ec":"3.5.4.11","compounds":"a 2-amino-4-hydroxypteridine + H(+) + H2O = a 2,4-dihydroxypteridine + NH4(+)"}
{"X":37861,"RHEA_ID":36056,"compounds":"a 2-amino-4-hydroxypteridine + H(+) + H2O => a 2,4-dihydroxypteridine + NH4(+)"}
{"X":37862,"RHEA_ID":36057,"compounds":"a 2,4-dihydroxypteridine + NH4(+) => a 2-amino-4-hydroxypteridine + H(+) + H2O"}
{"X":37863,"RHEA_ID":36058,"DIRECTION":"BI","MASTER_ID":36055,"metacyc":"PTERIN-DEAMINASE-RXN","compounds":"a 2-amino-4-hydroxypteridine + H(+) + H2O <=> a 2,4-dihydroxypteridine + NH4(+)"}
{"X":37864,"RHEA_ID":45980,"compounds":"3-oxochol-4-en-22-oyl-CoA + H(+) + NADH + O2 = 9alpha-hydroxy-3-oxochol-4-en-22-oyl-CoA + H2O + NAD(+)"}
{"X":37865,"RHEA_ID":45981,"compounds":"3-oxochol-4-en-22-oyl-CoA + H(+) + NADH + O2 => 9alpha-hydroxy-3-oxochol-4-en-22-oyl-CoA + H2O + NAD(+)"}
{"X":37866,"RHEA_ID":36061,"DIRECTION":"RL","MASTER_ID":36059,"metacyc":"RXN-14236","compounds":"AH2 + urocanate => A + dihydrourocanate"}
{"X":37867,"RHEA_ID":45983,"compounds":"3-oxochol-4-en-22-oyl-CoA + H(+) + NADH + O2 <=> 9alpha-hydroxy-3-oxochol-4-en-22-oyl-CoA + H2O + NAD(+)"}
{"X":37868,"RHEA_ID":45984,"compounds":"3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH + O2 = 9alpha-hydroxy-3-oxochola-1,4-dien-22-oyl-CoA + H2O + NAD(+)"}
{"X":37869,"RHEA_ID":45985,"compounds":"3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH + O2 => 9alpha-hydroxy-3-oxochola-1,4-dien-22-oyl-CoA + H2O + NAD(+)"}
{"X":37870,"RHEA_ID":36065,"compounds":"diphosphate + kunzeaol => (2E,6E)-farnesyl diphosphate + H2O"}
{"X":37871,"RHEA_ID":45987,"compounds":"3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH + O2 <=> 9alpha-hydroxy-3-oxochola-1,4-dien-22-oyl-CoA + H2O + NAD(+)"}
{"X":37872,"RHEA_ID":45988,"compounds":"3,17-dihydroxy-9,10-seconandrost-1,3,5(10)-triene-9-one + FMNH2 + O2 = 3,4,17-trihydroxy-9,10-seconandrost-1,3,5(10)-triene-9-one + FMN + H(+) + H2O"}
{"X":37873,"RHEA_ID":36068,"DIRECTION":"LR","MASTER_ID":36067,"metacyc":"RXN-8766","compounds":"Co-precorrin-6B + S-adenosyl-L-methionine => Co-precorrin-7 + CO2 + S-adenosyl-L-homocysteine"}
{"X":37874,"RHEA_ID":36069,"compounds":"Co-precorrin-7 + CO2 + S-adenosyl-L-homocysteine => Co-precorrin-6B + S-adenosyl-L-methionine"}
{"X":37875,"RHEA_ID":36070,"compounds":"Co-precorrin-6B + S-adenosyl-L-methionine <=> Co-precorrin-7 + CO2 + S-adenosyl-L-homocysteine"}
{"X":37876,"RHEA_ID":45992,"compounds":"(3R)-hydroxydecanoyl-CoA = (2E)-decenoyl-CoA + H2O"}
{"X":37877,"RHEA_ID":45993,"compounds":"(3R)-hydroxydecanoyl-CoA => (2E)-decenoyl-CoA + H2O"}
{"X":37878,"RHEA_ID":36073,"compounds":"D-glucose + tulipalin A => 6-tuliposide A"}
{"X":37879,"RHEA_ID":45995,"compounds":"(3R)-hydroxydecanoyl-CoA <=> (2E)-decenoyl-CoA + H2O"}
{"X":37880,"RHEA_ID":45996,"DIRECTION":"UN","MASTER_ID":45996,"ec":"1.4.5.1","compounds":"a D-alpha-amino acid + a quinone + H2O = a 2-oxocarboxylate + a quinol + NH4(+)"}
{"X":37881,"RHEA_ID":45997,"DIRECTION":"LR","MASTER_ID":45996,"ecocyc":"RXN-11193","metacyc":"RXN-11193","compounds":"a D-alpha-amino acid + a quinone + H2O => a 2-oxocarboxylate + a quinol + NH4(+)"}
{"X":37882,"RHEA_ID":36077,"compounds":"A + an N-acylsphing-4-enine + 2 H2O => AH2 + an N-acylsphinganine + O2"}
{"X":37883,"RHEA_ID":36078,"compounds":"AH2 + an N-acylsphinganine + O2 <=> A + an N-acylsphing-4-enine + 2 H2O"}
{"X":37884,"RHEA_ID":36079,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine = a 1,2-diacyl-sn-glycerol + N-acylsphing-4-enine 1-phosphoethanolamine"}
{"X":37885,"RHEA_ID":46001,"compounds":"adenosine + H(+) + tuberculosinyl diphosphate => 1-tuberculosinyladenosine + diphosphate"}
{"X":37886,"RHEA_ID":36081,"compounds":"a 1,2-diacyl-sn-glycerol + N-acylsphing-4-enine 1-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine"}
{"X":37887,"RHEA_ID":36082,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine <=> a 1,2-diacyl-sn-glycerol + N-acylsphing-4-enine 1-phosphoethanolamine"}
{"X":37888,"RHEA_ID":46004,"compounds":"2-methylpropanal + CoA + NAD(+) = 2-methylpropanoyl-CoA + H(+) + NADH"}
{"X":37889,"RHEA_ID":46005,"compounds":"2-methylpropanal + CoA + NAD(+) => 2-methylpropanoyl-CoA + H(+) + NADH"}
{"X":37890,"RHEA_ID":36085,"compounds":"1-O-alkyl-sn-glycerol + H(+) + phosphocholine => 1-O-alkyl-sn-glycero-3-phosphocholine + H2O"}
{"X":37891,"RHEA_ID":36086,"compounds":"1-O-alkyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-alkyl-sn-glycerol + H(+) + phosphocholine"}
{"X":37892,"RHEA_ID":36087,"compounds":"1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycerol + H(+) + phosphocholine"}
{"X":37893,"RHEA_ID":46009,"compounds":"CoA + NAD(+) + pentanal => H(+) + NADH + pentanoyl-CoA"}
{"X":37894,"RHEA_ID":36089,"compounds":"1-O-hexadecyl-sn-glycerol + H(+) + phosphocholine => 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O"}
{"X":37895,"RHEA_ID":36090,"compounds":"1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycerol + H(+) + phosphocholine"}
{"X":37896,"RHEA_ID":46012,"DIRECTION":"UN","MASTER_ID":46012,"ec":"1.1.5.4","compounds":"(S)-malate + a quinone = a quinol + oxaloacetate"}
{"X":37897,"RHEA_ID":36096,"DIRECTION":"LR","MASTER_ID":36095,"metacyc":"RXN-6723","compounds":"S-adenosyl-L-methionine + salicylate => methyl salicylate + S-adenosyl-L-homocysteine"}
{"X":37898,"RHEA_ID":36097,"compounds":"methyl salicylate + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + salicylate"}
{"X":37899,"RHEA_ID":56044,"DIRECTION":"UN","MASTER_ID":56044,"ec":"3.2.1.210","compounds":"H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) = beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B3)"}
{"X":37900,"RHEA_ID":46016,"compounds":"(20R)-20-hydroxypregn-4-en-3-one + NAD(+) = H(+) + NADH + progesterone"}
{"X":37901,"RHEA_ID":46017,"compounds":"(20R)-20-hydroxypregn-4-en-3-one + NAD(+) => H(+) + NADH + progesterone"}
{"X":37902,"RHEA_ID":36101,"compounds":"methyl benzoate + S-adenosyl-L-homocysteine => benzoate + S-adenosyl-L-methionine"}
{"X":37903,"RHEA_ID":46019,"compounds":"(20R)-20-hydroxypregn-4-en-3-one + NAD(+) <=> H(+) + NADH + progesterone"}
{"X":37904,"RHEA_ID":36103,"DIRECTION":"UN","MASTER_ID":36103,"ec":"2.1.1.277","compounds":"anthranilate + S-adenosyl-L-methionine = O-methyl anthranilate + S-adenosyl-L-homocysteine"}
{"X":37905,"RHEA_ID":46021,"compounds":"[pyruvate, water dikinase] + ADP => [pyruvate, water dikinase]-phosphate + AMP + H(+)"}
{"X":37906,"RHEA_ID":36105,"compounds":"O-methyl anthranilate + S-adenosyl-L-homocysteine => anthranilate + S-adenosyl-L-methionine"}
{"X":37907,"RHEA_ID":46023,"DIRECTION":"BI","MASTER_ID":46020,"metacyc":"RXN-13758","compounds":"[pyruvate, water dikinase] + ADP <=> [pyruvate, water dikinase]-phosphate + AMP + H(+)"}
{"X":37908,"RHEA_ID":36107,"DIRECTION":"UN","MASTER_ID":36107,"ec":"2.1.1.276","compounds":"gibberellin A4 + S-adenosyl-L-methionine = O-methyl gibberellin A4 + S-adenosyl-L-homocysteine"}
{"X":37909,"RHEA_ID":46025,"compounds":"H2O2 + tetradecanoate => (3R)-hydroxytetradecanoate + H2O"}
{"X":37910,"RHEA_ID":36108,"DIRECTION":"LR","MASTER_ID":36107,"metacyc":"RXN-11359","compounds":"gibberellin A4 + S-adenosyl-L-methionine => O-methyl gibberellin A4 + S-adenosyl-L-homocysteine"}
{"X":37911,"RHEA_ID":36109,"compounds":"O-methyl gibberellin A4 + S-adenosyl-L-homocysteine => gibberellin A4 + S-adenosyl-L-methionine"}
{"X":37912,"RHEA_ID":56057,"DIRECTION":"LR","MASTER_ID":56056,"metacyc":"RXN-3581","compounds":"genistein + UDP-alpha-D-glucose => genistein 7-O-beta-D-glucoside + H(+) + UDP"}
{"X":37913,"RHEA_ID":46029,"compounds":"H2O2 + tetradecanoate => (2R)-hydroxytetradecanoate + H2O"}
{"X":37914,"RHEA_ID":36112,"compounds":"gibberellin A1 + S-adenosyl-L-methionine => O-methyl gibberellin A1 + S-adenosyl-L-homocysteine"}
{"X":37915,"RHEA_ID":36113,"compounds":"O-methyl gibberellin A1 + S-adenosyl-L-homocysteine => gibberellin A1 + S-adenosyl-L-methionine"}
{"X":37916,"RHEA_ID":36114,"compounds":"gibberellin A1 + S-adenosyl-L-methionine <=> O-methyl gibberellin A1 + S-adenosyl-L-homocysteine"}
{"X":37917,"RHEA_ID":46033,"compounds":"H2O2 + tetradecanoate => (2S)-hydroxytetradecanoate + H2O"}
{"X":37918,"RHEA_ID":36115,"DIRECTION":"UN","MASTER_ID":36115,"ec":"2.1.1.276","compounds":"gibberellin A3 + S-adenosyl-L-methionine = O-methyl gibberellin A3 + S-adenosyl-L-homocysteine"}
{"X":37919,"RHEA_ID":36116,"compounds":"gibberellin A3 + S-adenosyl-L-methionine => O-methyl gibberellin A3 + S-adenosyl-L-homocysteine"}
{"X":37920,"RHEA_ID":46036,"DIRECTION":"UN","MASTER_ID":46036,"ec":"2.7.1.74","compounds":"2'-deoxycytidine + UTP = dCMP + H(+) + UDP"}
{"X":37921,"RHEA_ID":46037,"compounds":"2'-deoxycytidine + UTP => dCMP + H(+) + UDP"}
{"X":37922,"RHEA_ID":36119,"DIRECTION":"UN","MASTER_ID":36119,"ec":"2.1.1.275","compounds":"gibberellin A9 + S-adenosyl-L-methionine = O-methyl gibberellin A9 + S-adenosyl-L-homocysteine"}
{"X":37923,"RHEA_ID":36119,"DIRECTION":"UN","MASTER_ID":36119,"ec":"2.1.1.276","compounds":"gibberellin A9 + S-adenosyl-L-methionine = O-methyl gibberellin A9 + S-adenosyl-L-homocysteine"}
{"X":37924,"RHEA_ID":46040,"DIRECTION":"UN","MASTER_ID":46040,"ec":"2.7.1.145","compounds":"2'-deoxycytidine + ATP = ADP + dCMP + H(+)"}
{"X":37925,"RHEA_ID":46040,"DIRECTION":"UN","MASTER_ID":46040,"ec":"2.7.1.74","compounds":"2'-deoxycytidine + ATP = ADP + dCMP + H(+)"}
{"X":37926,"RHEA_ID":46041,"DIRECTION":"LR","MASTER_ID":46040,"reactome":"R-HSA-73598.4","compounds":"2'-deoxycytidine + ATP => ADP + dCMP + H(+)"}
{"X":37927,"RHEA_ID":36123,"DIRECTION":"UN","MASTER_ID":36123,"ec":"2.1.1.275","compounds":"gibberellin A20 + S-adenosyl-L-methionine = gibberellin A20 methyl ester + S-adenosyl-L-homocysteine"}
{"X":37928,"RHEA_ID":36124,"compounds":"gibberellin A20 + S-adenosyl-L-methionine => gibberellin A20 methyl ester + S-adenosyl-L-homocysteine"}
{"X":37929,"RHEA_ID":46044,"compounds":"(3Z)-octenoyl-CoA = (2E)-octenoyl-CoA"}
{"X":37930,"RHEA_ID":36126,"compounds":"gibberellin A20 + S-adenosyl-L-methionine <=> gibberellin A20 methyl ester + S-adenosyl-L-homocysteine"}
{"X":37931,"RHEA_ID":36127,"DIRECTION":"UN","MASTER_ID":36127,"ec":"2.1.1.275","compounds":"gibberellin A34 + S-adenosyl-L-methionine = O-methyl gibberellin A34 + S-adenosyl-L-homocysteine"}
{"X":37932,"RHEA_ID":36127,"DIRECTION":"UN","MASTER_ID":36127,"ec":"2.1.1.276","compounds":"gibberellin A34 + S-adenosyl-L-methionine = O-methyl gibberellin A34 + S-adenosyl-L-homocysteine"}
{"X":37933,"RHEA_ID":46048,"DIRECTION":"UN","MASTER_ID":46048,"ec":"5.4.2.13","compounds":"D-galactosamine 6-phosphate = alpha-D-galactosamine 1-phosphate"}
{"X":37934,"RHEA_ID":46049,"compounds":"D-galactosamine 6-phosphate => alpha-D-galactosamine 1-phosphate"}
{"X":37935,"RHEA_ID":36130,"compounds":"gibberellin A34 + S-adenosyl-L-methionine <=> O-methyl gibberellin A34 + S-adenosyl-L-homocysteine"}
{"X":37936,"RHEA_ID":36131,"DIRECTION":"UN","MASTER_ID":36131,"ec":"2.1.1.278","compounds":"(indol-3-yl)acetate + S-adenosyl-L-methionine = methyl (indol-3-yl)acetate + S-adenosyl-L-homocysteine"}
{"X":37937,"RHEA_ID":36132,"DIRECTION":"LR","MASTER_ID":36131,"metacyc":"RXN-9825","compounds":"(indol-3-yl)acetate + S-adenosyl-L-methionine => methyl (indol-3-yl)acetate + S-adenosyl-L-homocysteine"}
{"X":37938,"RHEA_ID":46053,"compounds":"U6 RNA 3'-terminal UU => U6 RNA 3'-terminal uridine 2',3'-cyclic phosphate + uridine"}
{"X":37939,"RHEA_ID":46054,"compounds":"U6 RNA 3'-terminal uridine 2',3'-cyclic phosphate + uridine => U6 RNA 3'-terminal UU"}
{"X":37940,"RHEA_ID":36135,"compounds":"(2E)-hexadecenal + H2O + NAD(+) = (E)-hexadec-2-enoate + 2 H(+) + NADH"}
{"X":37941,"RHEA_ID":36136,"compounds":"(2E)-hexadecenal + H2O + NAD(+) => (E)-hexadec-2-enoate + 2 H(+) + NADH"}
{"X":37942,"RHEA_ID":46057,"compounds":"(11E)-octadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => (11E,13Z)-octadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":37943,"RHEA_ID":36138,"compounds":"(2E)-hexadecenal + H2O + NAD(+) <=> (E)-hexadec-2-enoate + 2 H(+) + NADH"}
{"X":37944,"RHEA_ID":36139,"compounds":"(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate"}
{"X":37945,"RHEA_ID":36140,"compounds":"(E)-hexadec-2-enoate + ATP + CoA => (2E)-hexadecenoyl-CoA + AMP + diphosphate"}
{"X":37946,"RHEA_ID":56090,"compounds":"CMP + globoside DSGG + H(+) => CMP-N-acetyl-beta-neuraminate + globoside MSGG"}
{"X":37947,"RHEA_ID":36142,"compounds":"(E)-hexadec-2-enoate + ATP + CoA <=> (2E)-hexadecenoyl-CoA + AMP + diphosphate"}
{"X":37948,"RHEA_ID":36143,"compounds":"(2E)-hexadecenoyl-CoA + H(+) + NADPH = hexadecanoyl-CoA + NADP(+)"}
{"X":37949,"RHEA_ID":36144,"compounds":"(2E)-hexadecenoyl-CoA + H(+) + NADPH => hexadecanoyl-CoA + NADP(+)"}
{"X":37950,"RHEA_ID":46065,"compounds":"(11E)-octadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => (6Z,11E)-octadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":37951,"RHEA_ID":36146,"compounds":"(2E)-hexadecenoyl-CoA + H(+) + NADPH <=> hexadecanoyl-CoA + NADP(+)"}
{"X":37952,"RHEA_ID":36147,"DIRECTION":"UN","MASTER_ID":36147,"ec":"2.3.1.224","compounds":"acetyl-CoA + benzyl alcohol = benzyl acetate + CoA"}
{"X":37953,"RHEA_ID":36148,"DIRECTION":"LR","MASTER_ID":36147,"metacyc":"RXN-6762","compounds":"acetyl-CoA + benzyl alcohol => benzyl acetate + CoA"}
{"X":37954,"RHEA_ID":36149,"compounds":"benzyl acetate + CoA => acetyl-CoA + benzyl alcohol"}
{"X":37955,"RHEA_ID":46070,"compounds":"(2E)-nonenoyl-CoA => (3E)-nonenoyl-CoA"}
{"X":37956,"RHEA_ID":36151,"DIRECTION":"UN","MASTER_ID":36151,"ec":"2.3.1.224","compounds":"acetyl-CoA + cinnamyl alcohol = cinnamyl acetate + CoA"}
{"X":37957,"RHEA_ID":36152,"compounds":"acetyl-CoA + cinnamyl alcohol => cinnamyl acetate + CoA"}
{"X":37958,"RHEA_ID":56102,"compounds":"[small archaeal modifier protein]-C-terminal Gly-Gly-AMP + diphosphate => [small archaeal modifier protein]-C-terminal Gly-Gly + ATP + H(+)"}
{"X":37959,"RHEA_ID":46074,"compounds":"hexadecanoyl-CoA + NAD(+) => (2E)-hexadecenoyl-CoA + H(+) + NADH"}
{"X":37960,"RHEA_ID":36155,"DIRECTION":"UN","MASTER_ID":36155,"ec":"2.1.1.272","compounds":"AH2 + Co(II)-factor III + S-adenosyl-L-methionine = A + Co-precorrin-4 + S-adenosyl-L-homocysteine"}
{"X":37961,"RHEA_ID":36156,"DIRECTION":"LR","MASTER_ID":36155,"metacyc":"RXN-14314","compounds":"AH2 + Co(II)-factor III + S-adenosyl-L-methionine => A + Co-precorrin-4 + S-adenosyl-L-homocysteine"}
{"X":37962,"RHEA_ID":56106,"compounds":"4,4'-diaponeurosporenal + 2 A + 3 H2O => 2 AH2 + all-trans-4,4'-diaponeurosporene + 2 O2"}
{"X":37963,"RHEA_ID":36158,"compounds":"AH2 + Co(II)-factor III + S-adenosyl-L-methionine <=> A + Co-precorrin-4 + S-adenosyl-L-homocysteine"}
{"X":37964,"RHEA_ID":36159,"DIRECTION":"UN","MASTER_ID":36159,"ec":"1.3.7.11","compounds":"2,3-bis-(O-phytanyl)-sn-glycerol 1-phosphate + 16 oxidized [2Fe-2S]-[ferredoxin] = 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate + 16 H(+) + 16 reduced [2Fe-2S]-[ferredoxin]"}
{"X":37965,"RHEA_ID":36160,"compounds":"2,3-bis-(O-phytanyl)-sn-glycerol 1-phosphate + 16 oxidized [2Fe-2S]-[ferredoxin] => 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate + 16 H(+) + 16 reduced [2Fe-2S]-[ferredoxin]"}
{"X":37966,"RHEA_ID":56110,"compounds":"2'-hydroxygenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => genistein + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":37967,"RHEA_ID":46082,"compounds":"NAD(+) + tetracosanoyl-CoA => (2E)-tetracosenoyl-CoA + H(+) + NADH"}
{"X":37968,"RHEA_ID":36163,"DIRECTION":"UN","MASTER_ID":36163,"ec":"6.3.4.21","compounds":"5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate"}
{"X":37969,"RHEA_ID":36164,"DIRECTION":"LR","MASTER_ID":36163,"ecocyc":"NICOTINATEPRIBOSYLTRANS-RXN","metacyc":"NICOTINATEPRIBOSYLTRANS-RXN","compounds":"5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate => ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate"}
{"X":37970,"RHEA_ID":56114,"compounds":"3-(all-trans-nonaprenyl)benzene-1,2-diol + H2O + NADP(+) => 2-all-trans-nonaprenylphenol + H(+) + NADPH + O2"}
{"X":37971,"RHEA_ID":46086,"compounds":"glycerol + phosphate => H2O + sn-glycerol 1-phosphate"}
{"X":37972,"RHEA_ID":36167,"DIRECTION":"UN","MASTER_ID":36167,"ec":"3.1.3.89","compounds":"a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate"}
{"X":37973,"RHEA_ID":36168,"DIRECTION":"LR","MASTER_ID":36167,"ecocyc":"RXN0-3741","metacyc":"RXN0-3741","compounds":"a 2'-deoxyribonucleoside 5'-phosphate + H2O => a 2'-deoxyribonucleoside + phosphate"}
{"X":37974,"RHEA_ID":36169,"compounds":"a 2'-deoxyribonucleoside + phosphate => a 2'-deoxyribonucleoside 5'-phosphate + H2O"}
{"X":37975,"RHEA_ID":36171,"DIRECTION":"UN","MASTER_ID":36171,"ec":"2.5.1.26","compounds":"a 1-acylglycerone 3-phosphate + a long chain fatty alcohol = 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+)"}
{"X":37976,"RHEA_ID":36172,"compounds":"a 1-acylglycerone 3-phosphate + a long chain fatty alcohol => 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+)"}
{"X":37977,"RHEA_ID":36173,"compounds":"1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+) => a 1-acylglycerone 3-phosphate + a long chain fatty alcohol"}
{"X":37978,"RHEA_ID":36175,"DIRECTION":"UN","MASTER_ID":36175,"ec":"1.1.1.101","compounds":"1-O-alkylglycerone 3-phosphate + H(+) + NADPH = 1-O-alkyl-sn-glycero-3-phosphate + NADP(+)"}
{"X":37979,"RHEA_ID":36176,"compounds":"1-O-alkylglycerone 3-phosphate + H(+) + NADPH => 1-O-alkyl-sn-glycero-3-phosphate + NADP(+)"}
{"X":37980,"RHEA_ID":56126,"compounds":"AH2 + diphosphate + nonaflavuxanthin => A + all-trans-lycopene + dimethylallyl diphosphate + H2O"}
{"X":37981,"RHEA_ID":36179,"DIRECTION":"UN","MASTER_ID":36179,"ec":"2.7.8.2","compounds":"1-O-alkyl-2-acyl-sn-glycerol + CDP-choline = 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)"}
{"X":37982,"RHEA_ID":36180,"compounds":"1-O-alkyl-2-acyl-sn-glycerol + CDP-choline => 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)"}
{"X":37983,"RHEA_ID":56130,"compounds":"AH2 + diphosphate + flavuxanthin => A + dimethylallyl diphosphate + H2O + nonaflavuxanthin"}
{"X":37984,"RHEA_ID":46106,"compounds":"corticosterone + H2O + 2 oxidized [adrenodoxin] => 21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}
{"X":37985,"RHEA_ID":36183,"DIRECTION":"UN","MASTER_ID":36183,"ec":"2.7.8.2","compounds":"a 1-O-alkyl-2-acetyl-sn-glycerol + CDP-choline = 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+)"}
{"X":37986,"RHEA_ID":36184,"compounds":"a 1-O-alkyl-2-acetyl-sn-glycerol + CDP-choline => 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+)"}
{"X":37987,"RHEA_ID":56134,"compounds":"a thymidine dimer in DNA => (5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine in DNA"}
{"X":37988,"RHEA_ID":46110,"compounds":"(2E,6E,10E)-geranylgeranate + 3 H2O + 2 NADP(+) => (2E,6E,10E)-geranylgeraniol + H(+) + 2 NADPH + 2 O2"}
{"X":37989,"RHEA_ID":36187,"compounds":"1-O-alkyl-2-acyl-sn-glycerol + CDP-ethanolamine = 1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)"}
{"X":37990,"RHEA_ID":36188,"compounds":"1-O-alkyl-2-acyl-sn-glycerol + CDP-ethanolamine => 1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)"}
{"X":37991,"RHEA_ID":56138,"compounds":"2 a phenolic radical donor + 2 H2O => 2 a phenolic donor + H2O2"}
{"X":37992,"RHEA_ID":46114,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine"}
{"X":37993,"RHEA_ID":36191,"compounds":"1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + choline = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + ethanolamine"}
{"X":37994,"RHEA_ID":36192,"compounds":"1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + choline => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + ethanolamine"}
{"X":37995,"RHEA_ID":56142,"compounds":"adenosine + H(+) + L-methionine => H2O + S-adenosyl-L-methionine"}
{"X":37996,"RHEA_ID":36195,"compounds":"1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + a carboxylate + H(+)"}
{"X":37997,"RHEA_ID":36196,"compounds":"1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + a carboxylate + H(+)"}
{"X":37998,"RHEA_ID":56146,"compounds":"a quinone + H2O + nitrite => a quinol + nitrate"}
{"X":37999,"RHEA_ID":36199,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-O-(1Z-alkenyl)-sn-glycerol + H(+) + phosphoethanolamine"}
{"X":38000,"RHEA_ID":36200,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O => 1-O-(1Z-alkenyl)-sn-glycerol + H(+) + phosphoethanolamine"}
{"X":38001,"RHEA_ID":46125,"DIRECTION":"LR","MASTER_ID":46124,"metacyc":"1.14.13.99-RXN","compounds":"(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":38002,"RHEA_ID":36203,"DIRECTION":"UN","MASTER_ID":36203,"ec":"3.1.4.39","compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + ethanolamine + H(+)"}
{"X":38003,"RHEA_ID":36204,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + ethanolamine + H(+)"}
{"X":38004,"RHEA_ID":56154,"compounds":"(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA => (9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphocholine"}
{"X":38005,"RHEA_ID":36207,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an acyl-CoA = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + CoA"}
{"X":38006,"RHEA_ID":36208,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an acyl-CoA => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + CoA"}
{"X":38007,"RHEA_ID":56158,"compounds":"(12R-hydroxy-9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA => (12R)-hydroxy-(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine"}
{"X":38008,"RHEA_ID":36211,"compounds":"1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + phosphate"}
{"X":38009,"RHEA_ID":36212,"compounds":"1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + H2O => 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + phosphate"}
{"X":38010,"RHEA_ID":46137,"DIRECTION":"LR","MASTER_ID":46136,"metacyc":"RXN-11794","compounds":"aminopyrrolnitrin + H(+) + NADPH + 2 O2 => 2 H2O + NADP(+) + pyrrolnitrin"}
{"X":38011,"RHEA_ID":36215,"DIRECTION":"UN","MASTER_ID":36215,"ec":"2.7.8.1","compounds":"1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-ethanolamine = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)"}
{"X":38012,"RHEA_ID":36216,"compounds":"1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-ethanolamine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)"}
{"X":38013,"RHEA_ID":46141,"compounds":"cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 22R-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":38014,"RHEA_ID":46142,"compounds":"22R-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":38015,"RHEA_ID":36219,"DIRECTION":"UN","MASTER_ID":36219,"ec":"3.1.4.4","compounds":"1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + ethanolamine + H(+)"}
{"X":38016,"RHEA_ID":36220,"compounds":"1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + ethanolamine + H(+)"}
{"X":38017,"RHEA_ID":46145,"compounds":"cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":38018,"RHEA_ID":36223,"compounds":"1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O = 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + H(+) + phosphoethanolamine"}
{"X":38019,"RHEA_ID":36224,"compounds":"1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O => 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + H(+) + phosphoethanolamine"}
{"X":38020,"RHEA_ID":56174,"compounds":"8-demethyl-8-formylriboflavin 5'-phosphate + H2O => FMN + O2"}
{"X":38021,"RHEA_ID":36227,"compounds":"1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-choline = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)"}
{"X":38022,"RHEA_ID":36228,"compounds":"1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-choline => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)"}
{"X":38023,"RHEA_ID":56178,"compounds":"8-carboxy-8-demethylriboflavin 5'-phosphate + AH2 + H(+) => 8-demethyl-8-formylriboflavin 5'-phosphate + A + H2O"}
{"X":38024,"RHEA_ID":46154,"compounds":"15,9'-di-cis-phytofluene + a plastoquinol => 15-cis-phytoene + a plastoquinone"}
{"X":38025,"RHEA_ID":36231,"DIRECTION":"UN","MASTER_ID":36231,"ec":"3.1.1.4","compounds":"1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)"}
{"X":38026,"RHEA_ID":36232,"compounds":"1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O => 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)"}
{"X":38027,"RHEA_ID":46157,"DIRECTION":"LR","MASTER_ID":46156,"metacyc":"RXN-12244","compounds":"15,9'-di-cis-phytofluene + a plastoquinone => 9,9',15-tri-cis-zeta-carotene + a plastoquinol"}
{"X":38028,"RHEA_ID":36235,"compounds":"1-O-alkyl-sn-glycero-3-phosphate + an acyl-CoA = 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + CoA"}
{"X":38029,"RHEA_ID":36236,"compounds":"1-O-alkyl-sn-glycero-3-phosphate + an acyl-CoA => 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + CoA"}
{"X":38030,"RHEA_ID":46160,"DIRECTION":"UN","MASTER_ID":46160,"ec":"1.6.5.11","compounds":"a quinone + H(+) + NADH = a quinol + NAD(+)"}
{"X":38031,"RHEA_ID":36239,"DIRECTION":"UN","MASTER_ID":36239,"ec":"3.1.3.4","compounds":"1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-2-acyl-sn-glycerol + phosphate"}
{"X":38032,"RHEA_ID":36240,"compounds":"1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O => 1-O-alkyl-2-acyl-sn-glycerol + phosphate"}
{"X":38033,"RHEA_ID":56190,"compounds":"3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":38034,"RHEA_ID":36243,"DIRECTION":"UN","MASTER_ID":36243,"ec":"1.1.1.319","compounds":"acetate + NADP(+) + trans-anol = NADPH + trans-coumaryl acetate"}
{"X":38035,"RHEA_ID":36244,"compounds":"acetate + NADP(+) + trans-anol => NADPH + trans-coumaryl acetate"}
{"X":38036,"RHEA_ID":46166,"compounds":"a quinol + NADP(+) => a quinone + H(+) + NADPH"}
{"X":38037,"RHEA_ID":36246,"compounds":"acetate + NADP(+) + trans-anol <=> NADPH + trans-coumaryl acetate"}
{"X":38038,"RHEA_ID":36247,"DIRECTION":"UN","MASTER_ID":36247,"ec":"2.1.1.279","compounds":"S-adenosyl-L-methionine + trans-anol = H(+) + S-adenosyl-L-homocysteine + trans-anethole"}
{"X":38039,"RHEA_ID":36248,"DIRECTION":"LR","MASTER_ID":36247,"metacyc":"RXN-9312","compounds":"S-adenosyl-L-methionine + trans-anol => H(+) + S-adenosyl-L-homocysteine + trans-anethole"}
{"X":38040,"RHEA_ID":46170,"compounds":"AMP + diphosphate + pentanoyl-CoA => ATP + CoA + pentanoate"}
{"X":38041,"RHEA_ID":46171,"compounds":"ATP + CoA + pentanoate <=> AMP + diphosphate + pentanoyl-CoA"}
{"X":38042,"RHEA_ID":36251,"compounds":"ATP + CoA + trans-ferulate = (E)-feruloyl-CoA + AMP + diphosphate"}
{"X":38043,"RHEA_ID":36252,"DIRECTION":"LR","MASTER_ID":36251,"metacyc":"6.2.1.34-RXN","compounds":"ATP + CoA + trans-ferulate => (E)-feruloyl-CoA + AMP + diphosphate"}
{"X":38044,"RHEA_ID":46174,"compounds":"AMP + butanoyl-CoA + diphosphate => ATP + butanoate + CoA"}
{"X":38045,"RHEA_ID":46175,"compounds":"ATP + butanoate + CoA <=> AMP + butanoyl-CoA + diphosphate"}
{"X":38046,"RHEA_ID":36255,"DIRECTION":"UN","MASTER_ID":36255,"ec":"1.14.16.5","compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 1-O-(1,2-saturated-alkyl)-sn-glycerol + O2 = (6R)-L-erythro-6,7-dihydrobiopterin + a 1-(1-hydroxyalkyl)-sn-glycerol + H2O"}
{"X":38047,"RHEA_ID":36256,"DIRECTION":"LR","MASTER_ID":36255,"metacyc":"GLYCERYL-ETHER-MONOOXYGENASE-RXN","compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 1-O-(1,2-saturated-alkyl)-sn-glycerol + O2 => (6R)-L-erythro-6,7-dihydrobiopterin + a 1-(1-hydroxyalkyl)-sn-glycerol + H2O"}
{"X":38048,"RHEA_ID":56206,"compounds":"3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + CMP + H(+) => CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein]"}
{"X":38049,"RHEA_ID":36259,"compounds":"a 1-(1-hydroxyalkyl)-sn-glycerol = an aldehyde + glycerol"}
{"X":38050,"RHEA_ID":36260,"compounds":"a 1-(1-hydroxyalkyl)-sn-glycerol => an aldehyde + glycerol"}
{"X":38051,"RHEA_ID":46182,"compounds":"2-methylbutanoyl-CoA + AMP + diphosphate => 2-methylbutanoate + ATP + CoA"}
{"X":38052,"RHEA_ID":36263,"DIRECTION":"UN","MASTER_ID":36263,"ec":"2.6.99.3","compounds":"hydroxyurea + O-acetyl-L-serine = acetate + H(+) + O-ureido-L-serine"}
{"X":38053,"RHEA_ID":36264,"DIRECTION":"LR","MASTER_ID":36263,"metacyc":"RXN-14458","compounds":"hydroxyurea + O-acetyl-L-serine => acetate + H(+) + O-ureido-L-serine"}
{"X":38054,"RHEA_ID":46186,"compounds":"3-methylbutanoyl-CoA + AMP + diphosphate => ATP + CoA + isovalerate"}
{"X":38055,"RHEA_ID":46187,"compounds":"ATP + CoA + isovalerate <=> 3-methylbutanoyl-CoA + AMP + diphosphate"}
{"X":38056,"RHEA_ID":36267,"DIRECTION":"UN","MASTER_ID":36267,"ec":"1.14.13.178","compounds":"caffeine + H(+) + NADH + O2 = formaldehyde + H2O + NAD(+) + theobromine"}
{"X":38057,"RHEA_ID":36268,"DIRECTION":"LR","MASTER_ID":36267,"metacyc":"RXN-11513","compounds":"caffeine + H(+) + NADH + O2 => formaldehyde + H2O + NAD(+) + theobromine"}
{"X":38058,"RHEA_ID":46190,"compounds":"a carboxylate + NH4(+) => an aliphatic nitrile + 2 H2O"}
{"X":38059,"RHEA_ID":46191,"compounds":"an aliphatic nitrile + 2 H2O <=> a carboxylate + NH4(+)"}
{"X":38060,"RHEA_ID":36271,"DIRECTION":"UN","MASTER_ID":36271,"ec":"1.14.13.178","compounds":"caffeine + H(+) + NADPH + O2 = formaldehyde + H2O + NADP(+) + theobromine"}
{"X":38061,"RHEA_ID":36272,"compounds":"caffeine + H(+) + NADPH + O2 => formaldehyde + H2O + NADP(+) + theobromine"}
{"X":38062,"RHEA_ID":46194,"compounds":"3beta,7alpha-dihydroxyandrost-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":38063,"RHEA_ID":46195,"compounds":"3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta,7alpha-dihydroxyandrost-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":38064,"RHEA_ID":36275,"DIRECTION":"UN","MASTER_ID":36275,"ec":"1.14.13.178","compounds":"H(+) + NADPH + O2 + theophylline = 3-methylxanthine + formaldehyde + H2O + NADP(+)"}
{"X":38065,"RHEA_ID":36276,"DIRECTION":"LR","MASTER_ID":36275,"metacyc":"RXN-13108","compounds":"H(+) + NADPH + O2 + theophylline => 3-methylxanthine + formaldehyde + H2O + NADP(+)"}
{"X":38066,"RHEA_ID":46198,"compounds":"7alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + pregnenolone + reduced [NADPH--hemoprotein reductase]"}
{"X":38067,"RHEA_ID":46199,"compounds":"O2 + pregnenolone + reduced [NADPH--hemoprotein reductase] <=> 7alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":38068,"RHEA_ID":36279,"DIRECTION":"UN","MASTER_ID":36279,"ec":"1.14.13.178","compounds":"H(+) + NADH + O2 + theophylline = 3-methylxanthine + formaldehyde + H2O + NAD(+)"}
{"X":38069,"RHEA_ID":36280,"DIRECTION":"LR","MASTER_ID":36279,"metacyc":"RXN-13108","compounds":"H(+) + NADH + O2 + theophylline => 3-methylxanthine + formaldehyde + H2O + NAD(+)"}
{"X":38070,"RHEA_ID":36281,"compounds":"3-methylxanthine + formaldehyde + H2O + NAD(+) => H(+) + NADH + O2 + theophylline"}
{"X":38071,"RHEA_ID":46203,"compounds":"5alpha-androstane-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase] <=> 5alpha-androstane-3beta,6alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":38072,"RHEA_ID":36283,"DIRECTION":"UN","MASTER_ID":36283,"ec":"1.14.13.178","compounds":"1,7-dimethylxanthine + H(+) + NADPH + O2 = 7-methylxanthine + formaldehyde + H2O + NADP(+)"}
{"X":38073,"RHEA_ID":36284,"DIRECTION":"LR","MASTER_ID":36283,"metacyc":"RXN-11517","compounds":"1,7-dimethylxanthine + H(+) + NADPH + O2 => 7-methylxanthine + formaldehyde + H2O + NADP(+)"}
{"X":38074,"RHEA_ID":46206,"compounds":"androst-5-en-3beta,7alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => androst-5-en-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":38075,"RHEA_ID":46207,"compounds":"androst-5-en-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase] <=> androst-5-en-3beta,7alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":38076,"RHEA_ID":36287,"DIRECTION":"UN","MASTER_ID":36287,"ec":"1.14.13.179","compounds":"H(+) + NADPH + O2 + theobromine = 7-methylxanthine + formaldehyde + H2O + NADP(+)"}
{"X":38077,"RHEA_ID":36288,"DIRECTION":"LR","MASTER_ID":36287,"metacyc":"RXN-11516","compounds":"H(+) + NADPH + O2 + theobromine => 7-methylxanthine + formaldehyde + H2O + NADP(+)"}
{"X":38078,"RHEA_ID":46210,"compounds":"AMP + diphosphate + eicosanoyl-CoA => ATP + CoA + eicosanoate"}
{"X":38079,"RHEA_ID":46211,"compounds":"ATP + CoA + eicosanoate <=> AMP + diphosphate + eicosanoyl-CoA"}
{"X":38080,"RHEA_ID":49512,"compounds":"2-(phosphinatomethylidene)butanedioate + H2O = phosphinomethylisomalate"}
{"X":38081,"RHEA_ID":36292,"DIRECTION":"LR","MASTER_ID":36291,"metacyc":"RXN-13109","compounds":"3-methylxanthine + H(+) + NADPH + O2 => formaldehyde + H2O + NADP(+) + xanthine"}
{"X":38082,"RHEA_ID":46214,"compounds":"4-amino-5-aminomethyl-2-methylpyrimidine + formate => H2O + N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine"}
{"X":38083,"RHEA_ID":46215,"compounds":"H2O + N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine <=> 4-amino-5-aminomethyl-2-methylpyrimidine + formate"}
{"X":38084,"RHEA_ID":49516,"DIRECTION":"UN","MASTER_ID":49516,"ec":"1.14.11.54","compounds":"2-oxoglutarate + N(1)-methyladenosine in mRNA + O2 = adenosine in mRNA + CO2 + formaldehyde + succinate"}
{"X":38085,"RHEA_ID":36296,"DIRECTION":"LR","MASTER_ID":36295,"metacyc":"RXN-14475","compounds":"alpha-maltose 6'-phosphate + H2O => D-maltose + phosphate"}
{"X":38086,"RHEA_ID":46218,"compounds":"3beta-hydroxypregn-4-ene-20-one + NADP(+) => H(+) + NADPH + progesterone"}
{"X":38087,"RHEA_ID":46219,"compounds":"H(+) + NADPH + progesterone <=> 3beta-hydroxypregn-4-ene-20-one + NADP(+)"}
{"X":38088,"RHEA_ID":39624,"compounds":"3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+)"}
{"X":38089,"RHEA_ID":36300,"DIRECTION":"LR","MASTER_ID":36299,"metacyc":"RXN-1126","compounds":"(E)-caffeate + ATP + CoA => AMP + caffeoyl-CoA + diphosphate"}
{"X":38090,"RHEA_ID":36301,"compounds":"AMP + caffeoyl-CoA + diphosphate => (E)-caffeate + ATP + CoA"}
{"X":38091,"RHEA_ID":46223,"compounds":"androst-5-en-3beta,17beta-diol + NAD(+) <=> 3beta-hydroxyandrost-5-en-17-one + H(+) + NADH"}
{"X":38092,"RHEA_ID":36303,"DIRECTION":"UN","MASTER_ID":36303,"ec":"1.2.1.n2","compounds":"an acyl-CoA + 2 H(+) + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP(+)"}
{"X":38093,"RHEA_ID":36304,"compounds":"an acyl-CoA + 2 H(+) + 2 NADPH => a long-chain primary fatty alcohol + CoA + 2 NADP(+)"}
{"X":38094,"RHEA_ID":36305,"compounds":"a long-chain primary fatty alcohol + CoA + 2 NADP(+) => an acyl-CoA + 2 H(+) + 2 NADPH"}
{"X":38095,"RHEA_ID":46227,"compounds":"(E)-feruloyl-CoA + H2O <=> CoA + H(+) + trans-ferulate"}
{"X":38096,"RHEA_ID":36307,"compounds":"(E)-caffeoyl-CoA + H2O = 3,4-dihydroxybenzaldehyde + acetyl-CoA"}
{"X":38097,"RHEA_ID":36308,"DIRECTION":"LR","MASTER_ID":36307,"metacyc":"RXN-21005","compounds":"(E)-caffeoyl-CoA + H2O => 3,4-dihydroxybenzaldehyde + acetyl-CoA"}
{"X":38098,"RHEA_ID":46230,"compounds":"adenosine 3',5'-bisphosphate + H(+) + holo-[peptidyl-carrier protein] => apo-[peptidyl-carrier protein] + CoA"}
{"X":38099,"RHEA_ID":36310,"compounds":"(E)-caffeoyl-CoA + H2O <=> 3,4-dihydroxybenzaldehyde + acetyl-CoA"}
{"X":38100,"RHEA_ID":36311,"compounds":"3,4-dihydroxybenzaldehyde + H2O + NAD(+) = 3,4-dihydroxybenzoate + 2 H(+) + NADH"}
{"X":38101,"RHEA_ID":36312,"compounds":"3,4-dihydroxybenzaldehyde + H2O + NAD(+) => 3,4-dihydroxybenzoate + 2 H(+) + NADH"}
{"X":38102,"RHEA_ID":46234,"compounds":"(9Z,12Z,15Z)-hexadecatrienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => (9Z,12Z)-hexadecadienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}
{"X":38103,"RHEA_ID":36314,"compounds":"3,4-dihydroxybenzaldehyde + H2O + NAD(+) <=> 3,4-dihydroxybenzoate + 2 H(+) + NADH"}
{"X":38104,"RHEA_ID":36315,"DIRECTION":"UN","MASTER_ID":36315,"ec":"1.2.1.84","compounds":"2 H(+) + hexadecanoyl-CoA + 2 NADPH = CoA + hexadecan-1-ol + 2 NADP(+)"}
{"X":38105,"RHEA_ID":36316,"DIRECTION":"LR","MASTER_ID":36315,"metacyc":"RXN-17743","reactome":"R-HSA-390425.3","compounds":"2 H(+) + hexadecanoyl-CoA + 2 NADPH => CoA + hexadecan-1-ol + 2 NADP(+)"}
{"X":38106,"RHEA_ID":56264,"compounds":"CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = CMP + H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]"}
{"X":38107,"RHEA_ID":36317,"compounds":"CoA + hexadecan-1-ol + 2 NADP(+) => 2 H(+) + hexadecanoyl-CoA + 2 NADPH"}
{"X":38108,"RHEA_ID":36318,"compounds":"2 H(+) + hexadecanoyl-CoA + 2 NADPH <=> CoA + hexadecan-1-ol + 2 NADP(+)"}
{"X":38109,"RHEA_ID":36319,"DIRECTION":"UN","MASTER_ID":36319,"ec":"1.2.1.84","compounds":"2 H(+) + 2 NADPH + octadecanoyl-CoA = CoA + 2 NADP(+) + octadecan-1-ol"}
{"X":38110,"RHEA_ID":36320,"DIRECTION":"LR","MASTER_ID":36319,"metacyc":"RXN-17744","compounds":"2 H(+) + 2 NADPH + octadecanoyl-CoA => CoA + 2 NADP(+) + octadecan-1-ol"}
{"X":38111,"RHEA_ID":46243,"compounds":"2 [Fe(II)-cytochrome b5] + a (9Z)-hexadecenoyl-containing glycerolipid + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a (9Z,12E)-hexadecadienoyl-containing glycerolipid + 2 H2O"}
{"X":38112,"RHEA_ID":39648,"DIRECTION":"LR","MASTER_ID":39647,"metacyc":"RXN-12769","compounds":"AH2 + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose + S-adenosyl-L-methionine => 5'-deoxyadenosine + A + dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + H(+) + L-methionine + NH4(+)"}
{"X":38113,"RHEA_ID":36323,"compounds":"(9Z)-octadecenoyl-CoA + 2 H(+) + 2 NADPH = (9Z)-octadecen-1-ol + CoA + 2 NADP(+)"}
{"X":38114,"RHEA_ID":36324,"compounds":"(9Z)-octadecenoyl-CoA + 2 H(+) + 2 NADPH => (9Z)-octadecen-1-ol + CoA + 2 NADP(+)"}
{"X":38115,"RHEA_ID":36326,"compounds":"(9Z)-octadecenoyl-CoA + 2 H(+) + 2 NADPH <=> (9Z)-octadecen-1-ol + CoA + 2 NADP(+)"}
{"X":38116,"RHEA_ID":36327,"DIRECTION":"UN","MASTER_ID":36327,"ec":"2.5.1.112","compounds":"ADP + dimethylallyl diphosphate = diphosphate + N(6)-(dimethylallyl)adenosine 5'-diphosphate"}
{"X":38117,"RHEA_ID":46250,"compounds":"(14Z)-hexadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => 2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2"}
{"X":38118,"RHEA_ID":39656,"compounds":"(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + AH2 + O2 => (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + A + 2 H2O"}
{"X":38119,"RHEA_ID":36331,"DIRECTION":"UN","MASTER_ID":36331,"ec":"2.5.1.112","compounds":"ATP + dimethylallyl diphosphate = diphosphate + N(6)-(dimethylallyl)adenosine 5'-triphosphate"}
{"X":38120,"RHEA_ID":46254,"compounds":"2 [Fe(III)-cytochrome b5] + a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-containing glycerolipid + 2 H2O => 2 [Fe(II)-cytochrome b5] + a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-containing glycerolipid + 2 H(+) + O2"}
{"X":38121,"RHEA_ID":39659,"compounds":"3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine"}
{"X":38122,"RHEA_ID":39660,"compounds":"3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine => 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine"}
{"X":38123,"RHEA_ID":36335,"compounds":"D-glucuronate + H2O + NAD(+) = D-glucarate + 2 H(+) + NADH"}
{"X":38124,"RHEA_ID":46258,"compounds":"2 [Fe(III)-cytochrome b5] + a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-containing glycerolipid + 2 H2O => 2 [Fe(II)-cytochrome b5] + a (7Z,10Z,13Z,16Z)-docosatetraenoyl-containing glycerolipid + 2 H(+) + O2"}
{"X":38125,"RHEA_ID":46259,"DIRECTION":"BI","MASTER_ID":46256,"metacyc":"RXN-16111","compounds":"2 [Fe(II)-cytochrome b5] + a (7Z,10Z,13Z,16Z)-docosatetraenoyl-containing glycerolipid + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-containing glycerolipid + 2 H2O"}
{"X":38126,"RHEA_ID":39664,"compounds":"a quinol + H(+) + oxidized coenzyme F420-(gamma-Glu)(n) => a quinone + reduced coenzyme F420-(gamma-Glu)(n)"}
{"X":38127,"RHEA_ID":36339,"compounds":"[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine = 2-sulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine"}
{"X":38128,"RHEA_ID":36340,"DIRECTION":"LR","MASTER_ID":36339,"ecocyc":"RXN-14480","metacyc":"RXN-14480","compounds":"[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine => 2-sulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine"}
{"X":38129,"RHEA_ID":46263,"compounds":"2 [Fe(II)-cytochrome b5] + an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 H(+) + O2 <=> (5Z,8Z,11Z,14Z)-eicosatetraenoyl-containing glycerolipid + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":38130,"RHEA_ID":39668,"compounds":"a secondary alcohol + H(+) + oxidized coenzyme F420-(gamma-Glu)(n) => a ketone + reduced coenzyme F420-(gamma-Glu)(n)"}
{"X":38131,"RHEA_ID":36343,"compounds":"2-methylsulfanyl-N(6)-(Delta(2)-isopentenyl)adenosine in tRNA + H(+) + NADPH + O2 = 2-methylsulfanyl-N(6)-(cis-4-hydroxy-Delta(2)-isopentenyl)adenosine in tRNA + H2O + NADP(+)"}
{"X":38132,"RHEA_ID":46266,"compounds":"2 [Fe(III)-cytochrome b5] + a (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-containing glycerolipid + 2 H2O => 2 [Fe(II)-cytochrome b5] + an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 H(+) + O2"}
{"X":38133,"RHEA_ID":46267,"compounds":"2 [Fe(II)-cytochrome b5] + an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-containing glycerolipid + 2 H2O"}
{"X":38134,"RHEA_ID":39672,"compounds":"(9Z)-hexadecenoyl-CoA + AH2 + O2 => (9Z,12Z)-hexadecadienoyl-CoA + A + 2 H2O"}
{"X":38135,"RHEA_ID":36347,"DIRECTION":"UN","MASTER_ID":36347,"ec":"4.1.3.44","compounds":"N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + CO2 + H2O + L-methionine"}
{"X":38136,"RHEA_ID":36348,"DIRECTION":"LR","MASTER_ID":36347,"metacyc":"RXN-14516","compounds":"N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine => 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + CO2 + H2O + L-methionine"}
{"X":38137,"RHEA_ID":46272,"DIRECTION":"UN","MASTER_ID":46272,"ec":"1.14.19.29","compounds":"2 [Fe(II)-cytochrome b5] + an N-acyl-(4R)-4-hydroxysphinganine + 2 H(+) + O2 = (4R,8Z)-4-hydroxysphing-8-enine ceramide + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":38138,"RHEA_ID":36351,"DIRECTION":"UN","MASTER_ID":36351,"ec":"2.8.4.4","compounds":"AH2 + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-methionine = 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + A + H(+) + L-methionine"}
{"X":38139,"RHEA_ID":46274,"compounds":"(4R,8Z)-4-hydroxysphing-8-enine ceramide + 2 [Fe(III)-cytochrome b5] + 2 H2O => 2 [Fe(II)-cytochrome b5] + an N-acyl-(4R)-4-hydroxysphinganine + 2 H(+) + O2"}
{"X":38140,"RHEA_ID":36353,"compounds":"3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + A + H(+) + L-methionine => AH2 + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-methionine"}
{"X":38141,"RHEA_ID":39680,"compounds":"(11Z)-octadecenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(13Z)-eicosenoyl-CoA + CO2 + CoA"}
{"X":38142,"RHEA_ID":36355,"DIRECTION":"UN","MASTER_ID":36355,"ec":"2.5.1.114","compounds":"4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine"}
{"X":38143,"RHEA_ID":36356,"DIRECTION":"LR","MASTER_ID":36355,"metacyc":"RXN-14518","compounds":"4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine => 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine"}
{"X":38144,"RHEA_ID":56305,"DIRECTION":"LR","MASTER_ID":56304,"metacyc":"RXN-18733","compounds":"ATP + H2O + rifampicin => 21-phosphorifampicin + AMP + 2 H(+) + phosphate"}
{"X":38145,"RHEA_ID":46280,"DIRECTION":"UN","MASTER_ID":46280,"ec":"1.14.19.18","compounds":"2 [Fe(II)-cytochrome b5] + an N-acylsphing-4-enine + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 H2O"}
{"X":38146,"RHEA_ID":36359,"DIRECTION":"UN","MASTER_ID":36359,"ec":"1.10.3.9","compounds":"2 a plastoquinone + 2 H2O + 4 hnu = 2 a plastoquinol + O2"}
{"X":38147,"RHEA_ID":36360,"DIRECTION":"LR","MASTER_ID":36359,"metacyc":"PSII-RXN","compounds":"2 a plastoquinone + 2 H2O + 4 hnu => 2 a plastoquinol + O2"}
{"X":38148,"RHEA_ID":36361,"compounds":"2 a plastoquinol + O2 => 2 a plastoquinone + 2 H2O + 4 hnu"}
{"X":38149,"RHEA_ID":36363,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 2 H(+) + 2 NADPH = (9Z,12Z)-octadecadien-1-ol + CoA + 2 NADP(+)"}
{"X":38150,"RHEA_ID":46286,"compounds":"(6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(III)-cytochrome b5] + 2 H2O => 2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2"}
{"X":38151,"RHEA_ID":36365,"compounds":"(9Z,12Z)-octadecadien-1-ol + CoA + 2 NADP(+) => (9Z,12Z)-octadecadienoyl-CoA + 2 H(+) + 2 NADPH"}
{"X":38152,"RHEA_ID":39692,"compounds":"(2E,11Z)-octadecadienoyl-CoA + H(+) + NADPH => (11Z)-octadecenoyl-CoA + NADP(+)"}
{"X":38153,"RHEA_ID":36367,"compounds":"(S)-alpha-hydroxyglutarate-gamma-lactone + H2O = 2-hydroxyglutarate + H(+)"}
{"X":38154,"RHEA_ID":36368,"compounds":"(S)-alpha-hydroxyglutarate-gamma-lactone + H2O => 2-hydroxyglutarate + H(+)"}
{"X":38155,"RHEA_ID":36369,"compounds":"2-hydroxyglutarate + H(+) => (S)-alpha-hydroxyglutarate-gamma-lactone + H2O"}
{"X":38156,"RHEA_ID":46292,"DIRECTION":"UN","MASTER_ID":46292,"ec":"2.7.7.88","compounds":"a 5'-end triphospho-(purine-ribonucleotide) in mRNA + GDP + H(+) = a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + diphosphate"}
{"X":38157,"RHEA_ID":36371,"compounds":"(2S)-hydroxybutanoate + NAD(+) = 2-oxobutanoate + H(+) + NADH"}
{"X":38158,"RHEA_ID":36372,"compounds":"(2S)-hydroxybutanoate + NAD(+) => 2-oxobutanoate + H(+) + NADH"}
{"X":38159,"RHEA_ID":36373,"compounds":"2-oxobutanoate + H(+) + NADH => (2S)-hydroxybutanoate + NAD(+)"}
{"X":38160,"RHEA_ID":56322,"compounds":"an anthocyanin 5-O-beta-D-glucoside + H(+) + UDP => a 5-hydroxy anthocyanidin + UDP-alpha-D-glucose"}
{"X":38161,"RHEA_ID":36375,"compounds":"ATP + carbamoyl phosphate + H2O = carbamoyl adenylate + diphosphate + phosphate"}
{"X":38162,"RHEA_ID":46298,"compounds":"6beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone"}
{"X":38163,"RHEA_ID":36377,"compounds":"carbamoyl adenylate + diphosphate + phosphate => ATP + carbamoyl phosphate + H2O"}
{"X":38164,"RHEA_ID":56326,"compounds":"a deoxyribonucleotide in DNA + H(+) + S-methyl-L-cysteinyl-[protein] => a methylphosphotriester deoxyribonucleoside in DNA + L-cysteinyl-[protein]"}
{"X":38165,"RHEA_ID":36379,"DIRECTION":"UN","MASTER_ID":36379,"ec":"1.1.1.270","compounds":"4alpha-methyl-5alpha-cholesta-8,24-dien-3-one + H(+) + NADPH = 4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+)"}
{"X":38166,"RHEA_ID":36380,"DIRECTION":"LR","MASTER_ID":36379,"metacyc":"RXN66-314","compounds":"4alpha-methyl-5alpha-cholesta-8,24-dien-3-one + H(+) + NADPH => 4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+)"}
{"X":38167,"RHEA_ID":36381,"compounds":"4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) => 4alpha-methyl-5alpha-cholesta-8,24-dien-3-one + H(+) + NADPH"}
{"X":38168,"RHEA_ID":46304,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 16beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":38169,"RHEA_ID":46305,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 16beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":38170,"RHEA_ID":36384,"DIRECTION":"LR","MASTER_ID":36383,"metacyc":"RXN-13168","compounds":"carbamoyl adenylate + tobramycin => AMP + H(+) + nebramycin 5'"}
{"X":38171,"RHEA_ID":36385,"compounds":"AMP + H(+) + nebramycin 5' => carbamoyl adenylate + tobramycin"}
{"X":38172,"RHEA_ID":46308,"compounds":"O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 17alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":38173,"RHEA_ID":46309,"compounds":"O2 + progesterone + reduced [NADPH--hemoprotein reductase] => 17alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":38174,"RHEA_ID":36388,"DIRECTION":"LR","MASTER_ID":36387,"metacyc":"RXN-13167","compounds":"carbamoyl adenylate + kanamycin A => 6''-O-carbamoylkanamycin A + AMP + H(+)"}
{"X":38175,"RHEA_ID":36389,"compounds":"6''-O-carbamoylkanamycin A + AMP + H(+) => carbamoyl adenylate + kanamycin A"}
{"X":38176,"RHEA_ID":46312,"compounds":"3-oxochol-4-en-22-oyl-CoA + acetyl-CoA = 3,22-dioxochol-4-en-24-oyl-CoA + CoA"}
{"X":38177,"RHEA_ID":46313,"compounds":"3-oxochol-4-en-22-oyl-CoA + acetyl-CoA => 3,22-dioxochol-4-en-24-oyl-CoA + CoA"}
{"X":38178,"RHEA_ID":36392,"compounds":"cholesterol + NADP(+) => cholesta-5,24-dien-3beta-ol + H(+) + NADPH"}
{"X":38179,"RHEA_ID":36393,"DIRECTION":"RL","MASTER_ID":36391,"metacyc":"RXN66-28","compounds":"cholesta-5,24-dien-3beta-ol + H(+) + NADPH => cholesterol + NADP(+)"}
{"X":38180,"RHEA_ID":46316,"DIRECTION":"UN","MASTER_ID":46316,"ec":"3.2.1.184","compounds":"GDP-N,N'-diacetylbacillosamine + H2O = 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + GDP + H(+)"}
{"X":38181,"RHEA_ID":46317,"DIRECTION":"LR","MASTER_ID":46316,"metacyc":"RXN-12236","compounds":"GDP-N,N'-diacetylbacillosamine + H2O => 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + GDP + H(+)"}
{"X":38182,"RHEA_ID":46318,"compounds":"2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + GDP + H(+) => GDP-N,N'-diacetylbacillosamine + H2O"}
{"X":38183,"RHEA_ID":36397,"compounds":"cholesta-5,7,24-trien-3beta-ol + H(+) + NADPH => cholesta-5,7-dien-3beta-ol + NADP(+)"}
{"X":38184,"RHEA_ID":46320,"compounds":"3beta-hydroxy-chol-5-ene-24-oyl-CoA + A = 3beta-hydroxy-chol-5,22-dien-24-oyl-CoA + AH2"}
{"X":38185,"RHEA_ID":36399,"DIRECTION":"UN","MASTER_ID":36399,"ec":"1.3.1.72","compounds":"5alpha-cholest-8-en-3beta-ol + NADP(+) = 5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADPH"}
{"X":38186,"RHEA_ID":46322,"compounds":"3beta-hydroxy-chol-5,22-dien-24-oyl-CoA + AH2 => 3beta-hydroxy-chol-5-ene-24-oyl-CoA + A"}
{"X":38187,"RHEA_ID":36401,"compounds":"5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADPH => 5alpha-cholest-8-en-3beta-ol + NADP(+)"}
{"X":38188,"RHEA_ID":56350,"compounds":"2,4-dibromophenol + CO2 + 4 H2O + 2 NADP(+) => 4-hydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2"}
{"X":38189,"RHEA_ID":36403,"DIRECTION":"UN","MASTER_ID":36403,"ec":"3.1.1.13","compounds":"a cholesterol ester + H2O = a fatty acid + cholesterol + H(+)"}
{"X":38190,"RHEA_ID":46326,"compounds":"3-oxochola-4,17-dien-22-oyl-CoA + AH2 => 3-oxochol-4-en-22-oyl-CoA + A"}
{"X":38191,"RHEA_ID":36405,"compounds":"a fatty acid + cholesterol + H(+) => a cholesterol ester + H2O"}
{"X":38192,"RHEA_ID":36407,"DIRECTION":"UN","MASTER_ID":36407,"ec":"2.7.7.87","compounds":"ATP + hydrogencarbonate + L-threonine = diphosphate + H2O + L-threonylcarbamoyladenylate"}
{"X":38193,"RHEA_ID":36408,"compounds":"ATP + hydrogencarbonate + L-threonine => diphosphate + H2O + L-threonylcarbamoyladenylate"}
{"X":38194,"RHEA_ID":36409,"compounds":"diphosphate + H2O + L-threonylcarbamoyladenylate => ATP + hydrogencarbonate + L-threonine"}
{"X":38195,"RHEA_ID":46332,"DIRECTION":"UN","MASTER_ID":46332,"ec":"1.14.19.22","compounds":"2 [Fe(II)-cytochrome b5] + a (9Z)-octadecenoyl-containing glycerolipid + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H2O"}
{"X":38196,"RHEA_ID":46333,"DIRECTION":"LR","MASTER_ID":46332,"metacyc":"RXN-9669","compounds":"2 [Fe(II)-cytochrome b5] + a (9Z)-octadecenoyl-containing glycerolipid + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H2O"}
{"X":38197,"RHEA_ID":36412,"compounds":"cholesta-5,7-dien-3beta-ol + hnu => calciol"}
{"X":38198,"RHEA_ID":36413,"compounds":"calciol => cholesta-5,7-dien-3beta-ol + hnu"}
{"X":38199,"RHEA_ID":46336,"compounds":"3-oxochola-4,17-dien-22-oyl-CoA + H2O = 17-hydroxy-3-oxochol-4-en-22-oyl-CoA"}
{"X":38200,"RHEA_ID":36415,"DIRECTION":"UN","MASTER_ID":36415,"ec":"2.1.1.98","compounds":"2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine = diphthine-[translation elongation factor 2] + 3 H(+) + 3 S-adenosyl-L-homocysteine"}
{"X":38201,"RHEA_ID":36416,"DIRECTION":"LR","MASTER_ID":36415,"metacyc":"RXN-14326","compounds":"2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine => diphthine-[translation elongation factor 2] + 3 H(+) + 3 S-adenosyl-L-homocysteine"}
{"X":38202,"RHEA_ID":36417,"compounds":"diphthine-[translation elongation factor 2] + 3 H(+) + 3 S-adenosyl-L-homocysteine => 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine"}
{"X":38203,"RHEA_ID":46340,"compounds":"ATP + N-hexadecanoylsphing-4-enine = ADP + H(+) + N-(hexadecanoyl)-sphing-4-enine-1-phosphate"}
{"X":38204,"RHEA_ID":36419,"compounds":"2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine"}
{"X":38205,"RHEA_ID":36420,"DIRECTION":"LR","MASTER_ID":36419,"metacyc":"RXN-11370","compounds":"2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine => 2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine"}
{"X":38206,"RHEA_ID":36421,"compounds":"2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine => 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine"}
{"X":38207,"RHEA_ID":46344,"compounds":"propanoyl-CoA + tetradecanoyl-CoA = 3-oxo-2-methylhexadecanoyl-CoA + CoA"}
{"X":38208,"RHEA_ID":36423,"compounds":"2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine"}
{"X":38209,"RHEA_ID":46346,"compounds":"3-oxo-2-methylhexadecanoyl-CoA + CoA => propanoyl-CoA + tetradecanoyl-CoA"}
{"X":38210,"RHEA_ID":36425,"compounds":"2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine => 2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine"}
{"X":38211,"RHEA_ID":46348,"compounds":"(2E)-octenoyl-CoA + H2O = 3-hydroxyoctanoyl-CoA"}
{"X":38212,"RHEA_ID":36427,"compounds":"2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = diphthine-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine"}
{"X":38213,"RHEA_ID":36428,"DIRECTION":"LR","MASTER_ID":36427,"metacyc":"RXN-11373","compounds":"2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine => diphthine-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine"}
{"X":38214,"RHEA_ID":46351,"compounds":"(2E)-octenoyl-CoA + H2O <=> 3-hydroxyoctanoyl-CoA"}
{"X":38215,"RHEA_ID":46352,"compounds":"(2E)-decenoyl-CoA + H2O = 3-hydroxydecanoyl-CoA"}
{"X":38216,"RHEA_ID":36431,"DIRECTION":"UN","MASTER_ID":36431,"ec":"2.4.2.1","compounds":"a purine 2'-deoxy-D-ribonucleoside + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase"}
{"X":38217,"RHEA_ID":36432,"compounds":"a purine 2'-deoxy-D-ribonucleoside + phosphate => 2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase"}
{"X":38218,"RHEA_ID":36433,"compounds":"2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase => a purine 2'-deoxy-D-ribonucleoside + phosphate"}
{"X":38219,"RHEA_ID":36434,"compounds":"a purine 2'-deoxy-D-ribonucleoside + phosphate <=> 2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase"}
{"X":38220,"RHEA_ID":36435,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphate(in) = a 1,2-diacyl-sn-glycero-3-phosphate(out)"}
{"X":38221,"RHEA_ID":36436,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphate(in) => a 1,2-diacyl-sn-glycero-3-phosphate(out)"}
{"X":38222,"RHEA_ID":46359,"compounds":"O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":38223,"RHEA_ID":36438,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphate(in) <=> a 1,2-diacyl-sn-glycero-3-phosphate(out)"}
{"X":38224,"RHEA_ID":36439,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ADP + H(+) + phosphate"}
{"X":38225,"RHEA_ID":46362,"compounds":"1-acyl-2-[(R)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + 2 [Fe(III)-cytochrome b5] + H2O => 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}
{"X":38226,"RHEA_ID":36442,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ATP + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ADP + H(+) + phosphate"}
{"X":38227,"RHEA_ID":36443,"compounds":"dihydrochanoclavine-I aldehyde = 6,8-dimethyl-6,7-didehydroergoline + H2O"}
{"X":38228,"RHEA_ID":46366,"compounds":"2 [Fe(III)-cytochrome b5] + an N-acyl-(4R)-4-hydroxysphinganine + H2O => 2 [Fe(II)-cytochrome b5] + an N-acylsphinganine + 2 H(+) + O2"}
{"X":38229,"RHEA_ID":36446,"compounds":"dihydrochanoclavine-I aldehyde <=> 6,8-dimethyl-6,7-didehydroergoline + H2O"}
{"X":38230,"RHEA_ID":36447,"compounds":"ATP + glycyl-L-proline(out) + H2O = ADP + glycyl-L-proline(in) + H(+) + phosphate"}
{"X":38231,"RHEA_ID":36448,"compounds":"ATP + glycyl-L-proline(out) + H2O => ADP + glycyl-L-proline(in) + H(+) + phosphate"}
{"X":38232,"RHEA_ID":46371,"compounds":"2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a (9Z,11E,13E)-octadecatrienoyl-containing glycerolipid + 2 H2O"}
{"X":38233,"RHEA_ID":36450,"compounds":"ATP + glycyl-L-proline(out) + H2O <=> ADP + glycyl-L-proline(in) + H(+) + phosphate"}
{"X":38234,"RHEA_ID":36451,"compounds":"ATP + glycyl-L-glutamate(out) + H2O = ADP + glycyl-L-glutamate(in) + H(+) + phosphate"}
{"X":38235,"RHEA_ID":46374,"compounds":"2 [Fe(III)-cytochrome b5] + a (9Z,11E,13E,15Z)-octadecatetraenoyl-containing glycerolipid + 2 H2O => (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}
{"X":38236,"RHEA_ID":36453,"compounds":"ADP + glycyl-L-glutamate(in) + H(+) + phosphate => ATP + glycyl-L-glutamate(out) + H2O"}
{"X":38237,"RHEA_ID":36454,"compounds":"ATP + glycyl-L-glutamate(out) + H2O <=> ADP + glycyl-L-glutamate(in) + H(+) + phosphate"}
{"X":38238,"RHEA_ID":36455,"compounds":"ATP + H2O + L-alanylglycine(out) = ADP + H(+) + L-alanylglycine(in) + phosphate"}
{"X":38239,"RHEA_ID":36456,"compounds":"ATP + H2O + L-alanylglycine(out) => ADP + H(+) + L-alanylglycine(in) + phosphate"}
{"X":38240,"RHEA_ID":46379,"compounds":"a (9Z)-octadecenoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":38241,"RHEA_ID":36458,"compounds":"ATP + H2O + L-alanylglycine(out) <=> ADP + H(+) + L-alanylglycine(in) + phosphate"}
{"X":38242,"RHEA_ID":36459,"compounds":"glycyl-L-proline + H2O = glycine + L-proline"}
{"X":38243,"RHEA_ID":46382,"compounds":"(24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 7alpha-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":38244,"RHEA_ID":46383,"compounds":"7alpha-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":38245,"RHEA_ID":36462,"compounds":"glycyl-L-proline + H2O <=> glycine + L-proline"}
{"X":38246,"RHEA_ID":36463,"compounds":"glycyl-L-glutamate + H2O = glycine + L-glutamate"}
{"X":38247,"RHEA_ID":36464,"DIRECTION":"LR","MASTER_ID":36463,"metacyc":"RXN0-6984","compounds":"glycyl-L-glutamate + H2O => glycine + L-glutamate"}
{"X":38248,"RHEA_ID":46387,"compounds":"(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 24S,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":38249,"RHEA_ID":36466,"compounds":"glycyl-L-glutamate + H2O <=> glycine + L-glutamate"}
{"X":38250,"RHEA_ID":36467,"compounds":"H2O + L-alanylglycine = glycine + L-alanine"}
{"X":38251,"RHEA_ID":46390,"compounds":"(24S,25R)-24,26-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":38252,"RHEA_ID":46391,"compounds":"(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S,25R)-24,26-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":38253,"RHEA_ID":36470,"compounds":"H2O + L-alanylglycine <=> glycine + L-alanine"}
{"X":38254,"RHEA_ID":36471,"compounds":"3,4,5-trihydroxybenzoate(out) + H(+)(out) = 3,4,5-trihydroxybenzoate(in) + H(+)(in)"}
{"X":38255,"RHEA_ID":36472,"compounds":"3,4,5-trihydroxybenzoate(out) + H(+)(out) => 3,4,5-trihydroxybenzoate(in) + H(+)(in)"}
{"X":38256,"RHEA_ID":36473,"compounds":"3,4,5-trihydroxybenzoate(in) + H(+)(in) => 3,4,5-trihydroxybenzoate(out) + H(+)(out)"}
{"X":38257,"RHEA_ID":36474,"compounds":"3,4,5-trihydroxybenzoate(out) + H(+)(out) <=> 3,4,5-trihydroxybenzoate(in) + H(+)(in)"}
{"X":38258,"RHEA_ID":36475,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA = (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CO2 + CoA"}
{"X":38259,"RHEA_ID":36476,"DIRECTION":"LR","MASTER_ID":36475,"reactome":"R-HSA-548800.2","compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA => (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CO2 + CoA"}
{"X":38260,"RHEA_ID":46399,"DIRECTION":"BI","MASTER_ID":46396,"metacyc":"RXN-16428","compounds":"2 [Fe(II)-cytochrome b5] + an 11,12-saturated fatty acyl-CoA + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + an (11E)-Delta(11)-fatty acyl-CoA + 2 H2O"}
{"X":38261,"RHEA_ID":36478,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA <=> (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CO2 + CoA"}
{"X":38262,"RHEA_ID":36479,"compounds":"(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA = (9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + CO2 + CoA"}
{"X":38263,"RHEA_ID":36480,"compounds":"(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA => (9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + CO2 + CoA"}
{"X":38264,"RHEA_ID":46403,"compounds":"cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-cholest-5-ene-3beta,26-diol + H2O + 2 oxidized [adrenodoxin]"}
{"X":38265,"RHEA_ID":36482,"compounds":"(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA <=> (9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + CO2 + CoA"}
{"X":38266,"RHEA_ID":36483,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + malonyl-CoA = (7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + CO2 + CoA"}
{"X":38267,"RHEA_ID":36484,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + malonyl-CoA => (7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + CO2 + CoA"}
{"X":38268,"RHEA_ID":46407,"compounds":"2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 <=> (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":38269,"RHEA_ID":36486,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + malonyl-CoA <=> (7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + CO2 + CoA"}
{"X":38270,"RHEA_ID":36487,"DIRECTION":"UN","MASTER_ID":36487,"ec":"2.5.1.104","compounds":"agmatine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + N(1)-aminopropylagmatine + S-methyl-5'-thioadenosine"}
{"X":38271,"RHEA_ID":36488,"DIRECTION":"LR","MASTER_ID":36487,"metacyc":"RXN-12514","compounds":"agmatine + S-adenosyl 3-(methylsulfanyl)propylamine => H(+) + N(1)-aminopropylagmatine + S-methyl-5'-thioadenosine"}
{"X":38272,"RHEA_ID":36489,"compounds":"H(+) + N(1)-aminopropylagmatine + S-methyl-5'-thioadenosine => agmatine + S-adenosyl 3-(methylsulfanyl)propylamine"}
{"X":38273,"RHEA_ID":46412,"DIRECTION":"UN","MASTER_ID":46412,"ec":"1.14.19.35","compounds":"a (7Z,10Z)-hexadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a (7Z,10Z,13Z)-hexadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":38274,"RHEA_ID":36491,"compounds":"(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + H(+) + malonyl-CoA = (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + CO2 + CoA"}
{"X":38275,"RHEA_ID":36492,"compounds":"(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + H(+) + malonyl-CoA => (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + CO2 + CoA"}
{"X":38276,"RHEA_ID":46415,"compounds":"a (7Z,10Z)-hexadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a (7Z,10Z,13Z)-hexadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":38277,"RHEA_ID":36494,"compounds":"(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + H(+) + malonyl-CoA <=> (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + CO2 + CoA"}
{"X":38278,"RHEA_ID":36495,"compounds":"alpha-D-glucose + ATP = ADP + alpha-D-glucose 6-phosphate + H(+)"}
{"X":38279,"RHEA_ID":36496,"DIRECTION":"LR","MASTER_ID":36495,"metacyc":"RXN-1685","reactome":"R-HSA-70420.3","compounds":"alpha-D-glucose + ATP => ADP + alpha-D-glucose 6-phosphate + H(+)"}
{"X":38280,"RHEA_ID":36498,"compounds":"alpha-D-glucose + ATP <=> ADP + alpha-D-glucose 6-phosphate + H(+)"}
{"X":38281,"RHEA_ID":36499,"DIRECTION":"UN","MASTER_ID":36499,"ec":"1.1.1.401","compounds":"2-dehydro-3-deoxy-L-rhamnonate + NAD(+) = 2,4-didehydro-3-deoxy-L-rhamnonate + H(+) + NADH"}
{"X":38282,"RHEA_ID":36500,"DIRECTION":"LR","MASTER_ID":36499,"metacyc":"RXN-12095","compounds":"2-dehydro-3-deoxy-L-rhamnonate + NAD(+) => 2,4-didehydro-3-deoxy-L-rhamnonate + H(+) + NADH"}
{"X":38283,"RHEA_ID":46424,"DIRECTION":"UN","MASTER_ID":46424,"ec":"1.14.19.44","compounds":"(8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":38284,"RHEA_ID":36503,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + H(+) + malonyl-CoA = (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA"}
{"X":38285,"RHEA_ID":46426,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}
{"X":38286,"RHEA_ID":46427,"compounds":"(8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":38287,"RHEA_ID":36506,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + H(+) + malonyl-CoA <=> (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA"}
{"X":38288,"RHEA_ID":36507,"compounds":"docosanoyl-CoA + H(+) + malonyl-CoA = 3-oxotetracosanoyl-CoA + CO2 + CoA"}
{"X":38289,"RHEA_ID":46430,"compounds":"(25R)-4beta,26-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin] => 4beta-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}
{"X":38290,"RHEA_ID":46431,"compounds":"4beta-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-4beta,26-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin]"}
{"X":38291,"RHEA_ID":36510,"compounds":"docosanoyl-CoA + H(+) + malonyl-CoA <=> 3-oxotetracosanoyl-CoA + CO2 + CoA"}
{"X":38292,"RHEA_ID":36511,"compounds":"(9Z)-octadecenoyl-CoA + H(+) + malonyl-CoA = (11Z)-3-oxoicosenoyl-CoA + CO2 + CoA"}
{"X":38293,"RHEA_ID":46434,"compounds":"(25R)-3beta,4beta-dihydroxycholest-5-en-26-al + 2 H2O + 2 oxidized [adrenodoxin] => (25R)-4beta,26-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}
{"X":38294,"RHEA_ID":46435,"compounds":"(25R)-4beta,26-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta,4beta-dihydroxycholest-5-en-26-al + 2 H2O + 2 oxidized [adrenodoxin]"}
{"X":38295,"RHEA_ID":36514,"compounds":"(9Z)-octadecenoyl-CoA + H(+) + malonyl-CoA <=> (11Z)-3-oxoicosenoyl-CoA + CO2 + CoA"}
{"X":38296,"RHEA_ID":36515,"compounds":"H(+) + malonyl-CoA + tetracosanoyl-CoA = 3-oxohexacosanoyl-CoA + CO2 + CoA"}
{"X":38297,"RHEA_ID":36516,"DIRECTION":"LR","MASTER_ID":36515,"reactome":"R-HSA-548830.1","compounds":"H(+) + malonyl-CoA + tetracosanoyl-CoA => 3-oxohexacosanoyl-CoA + CO2 + CoA"}
{"X":38298,"RHEA_ID":36517,"compounds":"3-oxohexacosanoyl-CoA + CO2 + CoA => H(+) + malonyl-CoA + tetracosanoyl-CoA"}
{"X":38299,"RHEA_ID":36518,"compounds":"H(+) + malonyl-CoA + tetracosanoyl-CoA <=> 3-oxohexacosanoyl-CoA + CO2 + CoA"}
{"X":38300,"RHEA_ID":36519,"compounds":"H(+) + hexacosanoyl-CoA + malonyl-CoA = 3-oxooctacosanyol-CoA + CO2 + CoA"}
{"X":38301,"RHEA_ID":46442,"compounds":"A + a (8E,10E,12Z)-octadecatrienoyl-containing glycerolipid + 2 H2O => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + AH2 + O2"}
{"X":38302,"RHEA_ID":46443,"compounds":"a (9Z,12Z)-octadecadienoyl-containing glycerolipid + AH2 + O2 <=> A + a (8E,10E,12Z)-octadecatrienoyl-containing glycerolipid + 2 H2O"}
{"X":38303,"RHEA_ID":36522,"compounds":"H(+) + hexacosanoyl-CoA + malonyl-CoA <=> 3-oxooctacosanyol-CoA + CO2 + CoA"}
{"X":38304,"RHEA_ID":36523,"compounds":"(9Z,12Z,15Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA = (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA"}
{"X":38305,"RHEA_ID":46446,"compounds":"(10E,12Z)-hexadecadienoyl-CoA + A + 2 H2O => (11Z)-hexadecenoyl-CoA + AH2 + O2"}
{"X":38306,"RHEA_ID":36525,"compounds":"(11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA => (9Z,12Z,15Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA"}
{"X":38307,"RHEA_ID":46448,"DIRECTION":"UN","MASTER_ID":46448,"ec":"2.3.2.21","compounds":"2 L-tyrosyl-tRNA(Tyr) = cyclo(L-tyrosyl-L-tyrosyl) + 2 tRNA(Tyr)"}
{"X":38308,"RHEA_ID":36527,"compounds":"(11Z)-eicosenoyl-CoA + H(+) + malonyl-CoA = (13Z)-3-oxodocosenoyl-CoA + CO2 + CoA"}
{"X":38309,"RHEA_ID":36528,"compounds":"(11Z)-eicosenoyl-CoA + H(+) + malonyl-CoA => (13Z)-3-oxodocosenoyl-CoA + CO2 + CoA"}
{"X":38310,"RHEA_ID":36530,"compounds":"(11Z)-eicosenoyl-CoA + H(+) + malonyl-CoA <=> (13Z)-3-oxodocosenoyl-CoA + CO2 + CoA"}
{"X":38311,"RHEA_ID":36531,"compounds":"(13Z)-docosenoyl-CoA + H(+) + malonyl-CoA = (15Z)-3-oxotetracosenoyl-CoA + CO2 + CoA"}
{"X":38312,"RHEA_ID":36532,"compounds":"(13Z)-docosenoyl-CoA + H(+) + malonyl-CoA => (15Z)-3-oxotetracosenoyl-CoA + CO2 + CoA"}
{"X":38313,"RHEA_ID":36534,"compounds":"(13Z)-docosenoyl-CoA + H(+) + malonyl-CoA <=> (15Z)-3-oxotetracosenoyl-CoA + CO2 + CoA"}
{"X":38314,"RHEA_ID":46457,"compounds":"5alpha-cholest-8,14-dien-3beta-ol + H(+) + NADPH => 5alpha-cholest-8-en-3beta-ol + NADP(+)"}
{"X":38315,"RHEA_ID":36536,"compounds":"docosanoyl-CoA + sphinganine => CoA + H(+) + N-docosanoylsphinganine"}
{"X":38316,"RHEA_ID":46459,"compounds":"5alpha-cholest-8,14-dien-3beta-ol + H(+) + NADPH <=> 5alpha-cholest-8-en-3beta-ol + NADP(+)"}
{"X":38317,"RHEA_ID":36538,"compounds":"docosanoyl-CoA + sphinganine <=> CoA + H(+) + N-docosanoylsphinganine"}
{"X":38318,"RHEA_ID":46461,"compounds":"22R-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (22R,7alpha)-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":38319,"RHEA_ID":36540,"DIRECTION":"LR","MASTER_ID":36539,"metacyc":"RXN-20367","compounds":"hexadecanoyl-CoA + sphinganine => CoA + H(+) + N-hexadecanoylsphinganine"}
{"X":38320,"RHEA_ID":46463,"compounds":"22R-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (22R,7alpha)-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":38321,"RHEA_ID":36542,"compounds":"hexadecanoyl-CoA + sphinganine <=> CoA + H(+) + N-hexadecanoylsphinganine"}
{"X":38322,"RHEA_ID":46465,"compounds":"(24S)-25-epoxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24S,25)-epoxy-7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":38323,"RHEA_ID":36544,"compounds":"H2O + mycothiol S-conjugate => 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + an N-acetyl-L-cysteine-S-conjugate"}
{"X":38324,"RHEA_ID":46467,"compounds":"(24S)-25-epoxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S,25)-epoxy-7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":38325,"RHEA_ID":36546,"compounds":"H2O + mycothiol S-conjugate <=> 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + an N-acetyl-L-cysteine-S-conjugate"}
{"X":38326,"RHEA_ID":36547,"compounds":"octadecanoyl-CoA + sphinganine = CoA + H(+) + N-(octadecanoyl)-sphinganine"}
{"X":38327,"RHEA_ID":36548,"DIRECTION":"LR","MASTER_ID":36547,"metacyc":"RXN-20366","compounds":"octadecanoyl-CoA + sphinganine => CoA + H(+) + N-(octadecanoyl)-sphinganine"}
{"X":38328,"RHEA_ID":46471,"compounds":"an N-(acyl)-sphingosylphosphocholine(in) + ATP + H2O <=> ADP + an N-(acyl)-sphingosylphosphocholine(out) + H(+) + phosphate"}
{"X":38329,"RHEA_ID":36550,"compounds":"octadecanoyl-CoA + sphinganine <=> CoA + H(+) + N-(octadecanoyl)-sphinganine"}
{"X":38330,"RHEA_ID":36555,"compounds":"eicosanoyl-CoA + sphinganine = CoA + H(+) + N-eicosanoylsphinganine"}
{"X":38331,"RHEA_ID":46474,"compounds":"4alpha-hydroxymethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O => 4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}
{"X":38332,"RHEA_ID":36557,"compounds":"CoA + H(+) + N-eicosanoylsphinganine => eicosanoyl-CoA + sphinganine"}
{"X":38333,"RHEA_ID":36558,"compounds":"eicosanoyl-CoA + sphinganine <=> CoA + H(+) + N-eicosanoylsphinganine"}
{"X":38334,"RHEA_ID":36559,"compounds":"A + cis-4-hydroxy-D-proline = 4-hydroxy-1-pyrroline-2-carboxylate + AH2 + H(+)"}
{"X":38335,"RHEA_ID":46478,"compounds":"4alpha-formyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}
{"X":38336,"RHEA_ID":46479,"compounds":"4alpha-hydroxymethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 4alpha-formyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":38337,"RHEA_ID":46480,"compounds":"4alpha-formyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 = 4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":38338,"RHEA_ID":36563,"DIRECTION":"UN","MASTER_ID":36563,"ec":"1.1.1.356","compounds":"GDP-beta-L-colitose + NADP(+) = GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADPH"}
{"X":38339,"RHEA_ID":46482,"compounds":"4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O => 4alpha-formyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2"}
{"X":38340,"RHEA_ID":36565,"DIRECTION":"RL","MASTER_ID":36563,"metacyc":"RXN-8955","compounds":"GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADPH => GDP-beta-L-colitose + NADP(+)"}
{"X":38341,"RHEA_ID":46484,"DIRECTION":"UN","MASTER_ID":46484,"ec":"2.4.99.15","compounds":"alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate = alpha-Kdo-(2->4)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)"}
{"X":38342,"RHEA_ID":36567,"DIRECTION":"UN","MASTER_ID":36567,"ec":"1.1.1.356","compounds":"GDP-beta-L-colitose + NAD(+) = GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADH"}
{"X":38343,"RHEA_ID":36568,"compounds":"GDP-beta-L-colitose + NAD(+) => GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADH"}
{"X":38344,"RHEA_ID":36569,"DIRECTION":"RL","MASTER_ID":36567,"metacyc":"RXN-8955","compounds":"GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADH => GDP-beta-L-colitose + NAD(+)"}
{"X":38345,"RHEA_ID":46488,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out)"}
{"X":38346,"RHEA_ID":36571,"compounds":"sphinganine + tetradecanoyl-CoA = CoA + H(+) + N-(tetradecanoyl)-sphinganine"}
{"X":38347,"RHEA_ID":46490,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out) => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in)"}
{"X":38348,"RHEA_ID":36573,"compounds":"CoA + H(+) + N-(tetradecanoyl)-sphinganine => sphinganine + tetradecanoyl-CoA"}
{"X":38349,"RHEA_ID":36574,"compounds":"sphinganine + tetradecanoyl-CoA <=> CoA + H(+) + N-(tetradecanoyl)-sphinganine"}
{"X":38350,"RHEA_ID":36575,"compounds":"(9Z)-octadecenoyl-CoA + sphinganine = CoA + H(+) + N-(9Z-octadecenoyl)-sphinganine"}
{"X":38351,"RHEA_ID":46494,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(out) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(in)"}
{"X":38352,"RHEA_ID":46495,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(in) <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(out)"}
{"X":38353,"RHEA_ID":36578,"compounds":"(9Z)-octadecenoyl-CoA + sphinganine <=> CoA + H(+) + N-(9Z-octadecenoyl)-sphinganine"}
{"X":38354,"RHEA_ID":36579,"DIRECTION":"UN","MASTER_ID":36579,"ec":"1.1.1.266","compounds":"dTDP-alpha-D-fucose + NAD(+) = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH"}
{"X":38355,"RHEA_ID":36580,"compounds":"dTDP-alpha-D-fucose + NAD(+) => dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH"}
{"X":38356,"RHEA_ID":46499,"compounds":"N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(in) <=> N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(out)"}
{"X":38357,"RHEA_ID":46500,"DIRECTION":"UN","MASTER_ID":46500,"ec":"1.14.11.49","compounds":"2-oxoglutarate + O2 + UMP = CO2 + phosphate + succinate + uridine-5'-aldehyde"}
{"X":38358,"RHEA_ID":36583,"DIRECTION":"UN","MASTER_ID":36583,"ec":"1.1.1.266","compounds":"dTDP-alpha-D-fucose + NADP(+) = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH"}
{"X":38359,"RHEA_ID":36584,"compounds":"dTDP-alpha-D-fucose + NADP(+) => dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH"}
{"X":38360,"RHEA_ID":36585,"DIRECTION":"RL","MASTER_ID":36583,"metacyc":"1.1.1.266-RXN","compounds":"dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH => dTDP-alpha-D-fucose + NADP(+)"}
{"X":38361,"RHEA_ID":46504,"compounds":"dodecanoyl-AMP + holo-[ACP] = AMP + dodecanoyl-[ACP] + H(+)"}
{"X":38362,"RHEA_ID":36587,"DIRECTION":"UN","MASTER_ID":36587,"ec":"1.1.1.359","compounds":"an aldopyranose + NADP(+) = aldono-1,5-lactone + H(+) + NADPH"}
{"X":38363,"RHEA_ID":36588,"compounds":"an aldopyranose + NADP(+) => aldono-1,5-lactone + H(+) + NADPH"}
{"X":38364,"RHEA_ID":46507,"compounds":"dodecanoyl-AMP + holo-[ACP] <=> AMP + dodecanoyl-[ACP] + H(+)"}
{"X":38365,"RHEA_ID":36591,"DIRECTION":"UN","MASTER_ID":36591,"ec":"1.3.1.103","compounds":"(S)-2-chloropropanoate + NADP(+) = 2-chloroacrylate + H(+) + NADPH"}
{"X":38366,"RHEA_ID":46510,"compounds":"catechol + NAD(+) + nitrite => NADH + nitrobenzene + O2"}
{"X":38367,"RHEA_ID":56537,"compounds":"(12R)-hydroxy-(9Z)-octadecenoyl-CoA + 1,2-di-(12R-hydroxy-9Z-octadecenoyl)-sn-glycerol => 1,2,3-tri-(12R-hydroxy-9Z-octadecenoyl)-glycerol + CoA"}
{"X":38368,"RHEA_ID":46512,"DIRECTION":"UN","MASTER_ID":46512,"ec":"1.14.18.7","compounds":"2 [Fe(II)-cytochrome b5] + an N-(1,2-saturated acyl)sphinganine + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + an N-[(2'R)-hydroxyacyl]sphinganine + H2O"}
{"X":38369,"RHEA_ID":36595,"DIRECTION":"UN","MASTER_ID":36595,"ec":"1.8.1.18","compounds":"hydrogen sulfide + NADP(+) = NADPH + sulfur"}
{"X":38370,"RHEA_ID":36596,"compounds":"hydrogen sulfide + NADP(+) => NADPH + sulfur"}
{"X":38371,"RHEA_ID":36598,"compounds":"hydrogen sulfide + NADP(+) <=> NADPH + sulfur"}
{"X":38372,"RHEA_ID":36599,"DIRECTION":"UN","MASTER_ID":36599,"ec":"1.8.1.18","compounds":"hydrogen sulfide + NAD(+) = NADH + sulfur"}
{"X":38373,"RHEA_ID":46522,"compounds":"2 [Fe(III)-cytochrome b5] + an N-(2R-hydroxyacyl)-4R-hydroxysphinganine + H2O => 2 [Fe(II)-cytochrome b5] + an N-(1,2 saturated acyl)-4R-hydroxysphinganine + 2 H(+) + O2"}
{"X":38374,"RHEA_ID":46523,"compounds":"2 [Fe(II)-cytochrome b5] + an N-(1,2 saturated acyl)-4R-hydroxysphinganine + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + an N-(2R-hydroxyacyl)-4R-hydroxysphinganine + H2O"}
{"X":38375,"RHEA_ID":36602,"compounds":"hydrogen sulfide + NAD(+) <=> NADH + sulfur"}
{"X":38376,"RHEA_ID":36603,"DIRECTION":"UN","MASTER_ID":36603,"ec":"1.14.11.40","compounds":"2-oxoglutarate + L-enduracididine + O2 = (3S)-3-hydroxy-L-enduracididine + CO2 + succinate"}
{"X":38377,"RHEA_ID":36604,"DIRECTION":"LR","MASTER_ID":36603,"metacyc":"RXN-14541","compounds":"2-oxoglutarate + L-enduracididine + O2 => (3S)-3-hydroxy-L-enduracididine + CO2 + succinate"}
{"X":38378,"RHEA_ID":46527,"compounds":"(11Z,14Z)-eicosadienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> (5Z,11Z,14Z)-eicosatrienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":38379,"RHEA_ID":46528,"DIRECTION":"UN","MASTER_ID":46528,"ec":"1.14.19.37","compounds":"(11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":38380,"RHEA_ID":36607,"DIRECTION":"UN","MASTER_ID":36607,"ec":"1.14.11.41","compounds":"2-oxoglutarate + L-arginine + O2 = (2S,3S)-hydroxyarginine + CO2 + succinate"}
{"X":38381,"RHEA_ID":46530,"compounds":"(5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => (11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}
{"X":38382,"RHEA_ID":46531,"compounds":"(11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":38383,"RHEA_ID":46532,"DIRECTION":"UN","MASTER_ID":46532,"ec":"1.14.19.16","compounds":"2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a (9Z,11E,13Z)-octadeca-9,11,13-trienoyl-containing glycerolipid + 2 H2O"}
{"X":38384,"RHEA_ID":36611,"DIRECTION":"UN","MASTER_ID":36611,"ec":"1.14.20.3","compounds":"(3S,5S)-carbapenam-3-caboxylate + 2-oxoglutarate + O2 = (5R)-carbapenem-3-carboxylate + CO2 + H2O + succinate"}
{"X":38385,"RHEA_ID":46534,"compounds":"2 [Fe(III)-cytochrome b5] + a (9Z,11E,13Z)-octadeca-9,11,13-trienoyl-containing glycerolipid + 2 H2O => 2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2"}
{"X":38386,"RHEA_ID":46535,"compounds":"2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a (9Z,11E,13Z)-octadeca-9,11,13-trienoyl-containing glycerolipid + 2 H2O"}
{"X":38387,"RHEA_ID":46536,"DIRECTION":"UN","MASTER_ID":46536,"ec":"1.14.19.38","compounds":"(6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a (9Z,12Z)-octadeca-9,12-dien-6-ynoyl-containing glycerolipid + 2 H2O"}
{"X":38388,"RHEA_ID":36615,"compounds":"2-hydroxyoctadecanoyl-CoA + sphinganine = CoA + H(+) + N-(2-hydroxyoctadecanoyl)sphinganine"}
{"X":38389,"RHEA_ID":36616,"compounds":"2-hydroxyoctadecanoyl-CoA + sphinganine => CoA + H(+) + N-(2-hydroxyoctadecanoyl)sphinganine"}
{"X":38390,"RHEA_ID":46539,"compounds":"(6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a (9Z,12Z)-octadeca-9,12-dien-6-ynoyl-containing glycerolipid + 2 H2O"}
{"X":38391,"RHEA_ID":36618,"compounds":"2-hydroxyoctadecanoyl-CoA + sphinganine <=> CoA + H(+) + N-(2-hydroxyoctadecanoyl)sphinganine"}
{"X":38392,"RHEA_ID":36619,"compounds":"2-hydroxydocosanoyl-CoA + sphinganine = CoA + H(+) + N-(2-hydroxydocosanoyl)-sphinganine"}
{"X":38393,"RHEA_ID":36620,"compounds":"2-hydroxydocosanoyl-CoA + sphinganine => CoA + H(+) + N-(2-hydroxydocosanoyl)-sphinganine"}
{"X":38394,"RHEA_ID":56564,"DIRECTION":"UN","MASTER_ID":56564,"ec":"2.4.2.n2","compounds":"3-O-(beta-D-glucosyl)-L-threonyl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-threonyl-[EGF-like domain protein] + H(+) + UDP"}
{"X":38395,"RHEA_ID":36622,"compounds":"2-hydroxydocosanoyl-CoA + sphinganine <=> CoA + H(+) + N-(2-hydroxydocosanoyl)-sphinganine"}
{"X":38396,"RHEA_ID":36623,"DIRECTION":"UN","MASTER_ID":36623,"ec":"2.1.1.281","compounds":"3-phenylpyruvate + S-adenosyl-L-methionine = (3S)-2-oxo-3-phenylbutanoate + H(+) + S-adenosyl-L-homocysteine"}
{"X":38397,"RHEA_ID":36624,"DIRECTION":"LR","MASTER_ID":36623,"metacyc":"RXN-14468","compounds":"3-phenylpyruvate + S-adenosyl-L-methionine => (3S)-2-oxo-3-phenylbutanoate + H(+) + S-adenosyl-L-homocysteine"}
{"X":38398,"RHEA_ID":46548,"DIRECTION":"UN","MASTER_ID":46548,"ec":"1.14.19.19","compounds":"2 [Fe(II)-cytochrome b5] + a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + 2 H2O + N-acyl-(4E,8E,10E)-sphingatrienine"}
{"X":38399,"RHEA_ID":36627,"compounds":"2-hydroxytetracosanoyl-CoA + sphinganine = CoA + H(+) + N-(2-hydroxytetracosanoyl)sphinganine"}
{"X":38400,"RHEA_ID":36628,"compounds":"2-hydroxytetracosanoyl-CoA + sphinganine => CoA + H(+) + N-(2-hydroxytetracosanoyl)sphinganine"}
{"X":38401,"RHEA_ID":56572,"compounds":"beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-alpha-D-galactose = globoside Gb3Cer + H(+) + UDP"}
{"X":38402,"RHEA_ID":36630,"compounds":"2-hydroxytetracosanoyl-CoA + sphinganine <=> CoA + H(+) + N-(2-hydroxytetracosanoyl)sphinganine"}
{"X":38403,"RHEA_ID":36631,"compounds":"D-ribulose 1,5-bisphosphate + O2 = (2R)-3-phosphoglycerate + 2-phosphoglycolate + 2 H(+)"}
{"X":38404,"RHEA_ID":36632,"DIRECTION":"LR","MASTER_ID":36631,"metacyc":"RXN-961","compounds":"D-ribulose 1,5-bisphosphate + O2 => (2R)-3-phosphoglycerate + 2-phosphoglycolate + 2 H(+)"}
{"X":38405,"RHEA_ID":46555,"compounds":"2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a (9Z)-octadec-9-en-12-ynoyl-containing glycerolipid + 2 H2O"}
{"X":38406,"RHEA_ID":46556,"DIRECTION":"UN","MASTER_ID":46556,"ec":"1.14.19.20","compounds":"5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + cholesta-5,7-dien-3beta-ol + 2 H2O"}
{"X":38407,"RHEA_ID":36635,"DIRECTION":"UN","MASTER_ID":36635,"ec":"2.1.1.282","compounds":"4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-adenosyl-L-homocysteine"}
{"X":38408,"RHEA_ID":36636,"DIRECTION":"LR","MASTER_ID":36635,"metacyc":"RXN-14519","compounds":"4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine => 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-adenosyl-L-homocysteine"}
{"X":38409,"RHEA_ID":39966,"compounds":"2-hexadecanoylglycerol + H2O <=> glycerol + H(+) + hexadecanoate"}
{"X":38410,"RHEA_ID":46560,"DIRECTION":"UN","MASTER_ID":46560,"ec":"1.14.19.20","compounds":"2 [Fe(II)-cytochrome b5] + episterol + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + ergosta-5,7,24(28)-trien-3beta-ol + 2 H2O"}
{"X":38411,"RHEA_ID":36639,"DIRECTION":"UN","MASTER_ID":36639,"ec":"2.1.1.294","compounds":"3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-di-trans,octa-cis-undecaprenol + S-adenosyl-L-methionine = 3-O-methylphospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenol + S-adenosyl-L-homocysteine"}
{"X":38412,"RHEA_ID":36640,"DIRECTION":"LR","MASTER_ID":36639,"metacyc":"RXN-14705","compounds":"3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-di-trans,octa-cis-undecaprenol + S-adenosyl-L-methionine => 3-O-methylphospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenol + S-adenosyl-L-homocysteine"}
{"X":38413,"RHEA_ID":59993,"compounds":"H(+) + oxidized [electron-transfer flavoprotein] + phloretate => reduced [electron-transfer flavoprotein] + trans-4-coumarate"}
{"X":38414,"RHEA_ID":46564,"compounds":"acetyl-CoA + apo-[ACP] = acetyl-[ACP] + adenosine 3',5'-bisphosphate + H(+)"}
{"X":38415,"RHEA_ID":36643,"DIRECTION":"UN","MASTER_ID":36643,"ec":"2.1.1.283","compounds":"emodin + S-adenosyl-L-methionine = H(+) + questin + S-adenosyl-L-homocysteine"}
{"X":38416,"RHEA_ID":36644,"DIRECTION":"LR","MASTER_ID":36643,"metacyc":"RXN-13550","compounds":"emodin + S-adenosyl-L-methionine => H(+) + questin + S-adenosyl-L-homocysteine"}
{"X":38417,"RHEA_ID":46567,"compounds":"acetyl-CoA + apo-[ACP] <=> acetyl-[ACP] + adenosine 3',5'-bisphosphate + H(+)"}
{"X":38418,"RHEA_ID":46568,"DIRECTION":"UN","MASTER_ID":46568,"ec":"1.14.19.40","compounds":"5-hexenoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 5-hexynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":38419,"RHEA_ID":36647,"compounds":"2-hydroxyhexadecanoyl-CoA + sphinganine = CoA + H(+) + N-(2-hydroxyhexadecanoyl)-sphinganine"}
{"X":38420,"RHEA_ID":36648,"compounds":"2-hydroxyhexadecanoyl-CoA + sphinganine => CoA + H(+) + N-(2-hydroxyhexadecanoyl)-sphinganine"}
{"X":38421,"RHEA_ID":46571,"compounds":"5-hexenoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 5-hexynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":38422,"RHEA_ID":36650,"compounds":"2-hydroxyhexadecanoyl-CoA + sphinganine <=> CoA + H(+) + N-(2-hydroxyhexadecanoyl)-sphinganine"}
{"X":38423,"RHEA_ID":36651,"DIRECTION":"UN","MASTER_ID":36651,"ec":"2.1.1.284","compounds":"8-desmethylnovobiocic acid + S-adenosyl-L-methionine = H(+) + novobiocic acid + S-adenosyl-L-homocysteine"}
{"X":38424,"RHEA_ID":36652,"DIRECTION":"LR","MASTER_ID":36651,"metacyc":"RXN-14543","compounds":"8-desmethylnovobiocic acid + S-adenosyl-L-methionine => H(+) + novobiocic acid + S-adenosyl-L-homocysteine"}
{"X":38425,"RHEA_ID":46575,"compounds":"2 H(+) + hexanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 5-hexenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":38426,"RHEA_ID":46576,"DIRECTION":"UN","MASTER_ID":46576,"ec":"1.14.19.41","compounds":"(24R)-ethylcholest-5-en-3beta-ol + H(+) + NADPH + O2 = 2 H2O + NADP(+) + stigmasterol"}
{"X":38427,"RHEA_ID":36655,"DIRECTION":"UN","MASTER_ID":36655,"ec":"2.1.1.285","compounds":"desmethyldescarbamoylnovobiocin + S-adenosyl-L-methionine = descarbamoylnovobiocin + H(+) + S-adenosyl-L-homocysteine"}
{"X":38428,"RHEA_ID":36656,"DIRECTION":"LR","MASTER_ID":36655,"metacyc":"RXN-14545","compounds":"desmethyldescarbamoylnovobiocin + S-adenosyl-L-methionine => descarbamoylnovobiocin + H(+) + S-adenosyl-L-homocysteine"}
{"X":38429,"RHEA_ID":39986,"compounds":"2 [Fe(II)-cytochrome b5] + a 1,2-saturated fatty acid + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a 2-hydroxy fatty acid + H2O"}
{"X":38430,"RHEA_ID":46580,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + vitamin D2 = 25-hydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":38431,"RHEA_ID":36659,"DIRECTION":"UN","MASTER_ID":36659,"ec":"2.1.3.12","compounds":"carbamoyl phosphate + descarbamoylnovobiocin = novobiocin + phosphate"}
{"X":38432,"RHEA_ID":36660,"DIRECTION":"LR","MASTER_ID":36659,"metacyc":"RXN-14546","compounds":"carbamoyl phosphate + descarbamoylnovobiocin => novobiocin + phosphate"}
{"X":38433,"RHEA_ID":46583,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + vitamin D2 <=> 25-hydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":38434,"RHEA_ID":46584,"compounds":"1alpha-hydroxyvitamin D2 + O2 + reduced [NADPH--hemoprotein reductase] = 1alpha,25-dihydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":38435,"RHEA_ID":36663,"DIRECTION":"UN","MASTER_ID":36663,"ec":"2.3.1.226","compounds":"(S)-1-pyrroline-5-carboxylate + H(+) + H2O + malonyl-CoA = (2S,5S)-5-carboxymethylproline + CO2 + CoA"}
{"X":38436,"RHEA_ID":36664,"DIRECTION":"LR","MASTER_ID":36663,"metacyc":"RXN-8947","compounds":"(S)-1-pyrroline-5-carboxylate + H(+) + H2O + malonyl-CoA => (2S,5S)-5-carboxymethylproline + CO2 + CoA"}
{"X":38437,"RHEA_ID":56608,"compounds":"5,10-methylenetetrahydrosulfopterin + glycine + H2O = L-serine + tetrahydrosulfopterin"}
{"X":38438,"RHEA_ID":46588,"compounds":"calciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = calcidiol + H2O + 2 oxidized [adrenodoxin]"}
{"X":38439,"RHEA_ID":36667,"compounds":"(15Z)-tetracosenoyl-CoA + sphinganine = CoA + H(+) + N-(15Z-tetracosenoyl)-sphinganine"}
{"X":38440,"RHEA_ID":36668,"compounds":"(15Z)-tetracosenoyl-CoA + sphinganine => CoA + H(+) + N-(15Z-tetracosenoyl)-sphinganine"}
{"X":38441,"RHEA_ID":46591,"compounds":"calciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> calcidiol + H2O + 2 oxidized [adrenodoxin]"}
{"X":38442,"RHEA_ID":36670,"compounds":"(15Z)-tetracosenoyl-CoA + sphinganine <=> CoA + H(+) + N-(15Z-tetracosenoyl)-sphinganine"}
{"X":38443,"RHEA_ID":36671,"compounds":"(17Z)-hexacosenoyl-CoA + sphinganine = CoA + H(+) + N-[(17Z)-hexacosenoyl]dihydrosphingosine"}
{"X":38444,"RHEA_ID":36672,"compounds":"(17Z)-hexacosenoyl-CoA + sphinganine => CoA + H(+) + N-[(17Z)-hexacosenoyl]dihydrosphingosine"}
{"X":38445,"RHEA_ID":56616,"compounds":"(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene = 1,2,4-trichlorobenzene + chloride + H(+)"}
{"X":38446,"RHEA_ID":36674,"compounds":"(17Z)-hexacosenoyl-CoA + sphinganine <=> CoA + H(+) + N-[(17Z)-hexacosenoyl]dihydrosphingosine"}
{"X":38447,"RHEA_ID":36675,"compounds":"octacosanoyl-CoA + sphinganine = CoA + H(+) + N-(octacosanoyl)-sphinganine"}
{"X":38448,"RHEA_ID":36676,"compounds":"octacosanoyl-CoA + sphinganine => CoA + H(+) + N-(octacosanoyl)-sphinganine"}
{"X":38449,"RHEA_ID":36677,"compounds":"CoA + H(+) + N-(octacosanoyl)-sphinganine => octacosanoyl-CoA + sphinganine"}
{"X":38450,"RHEA_ID":36678,"compounds":"octacosanoyl-CoA + sphinganine <=> CoA + H(+) + N-(octacosanoyl)-sphinganine"}
{"X":38451,"RHEA_ID":36679,"DIRECTION":"UN","MASTER_ID":36679,"ec":"1.1.1.364","compounds":"dTDP-6-deoxy-alpha-D-allose + NAD(+) = dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADH"}
{"X":38452,"RHEA_ID":36680,"compounds":"dTDP-6-deoxy-alpha-D-allose + NAD(+) => dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADH"}
{"X":38453,"RHEA_ID":46603,"compounds":"[HPr protein]-L-serine + ATP <=> [HPr protein]-O-phospho-L-serine + ADP + H(+)"}
{"X":38454,"RHEA_ID":56625,"DIRECTION":"LR","MASTER_ID":56624,"metacyc":"LINB2-RXN","compounds":"2,4,5-trichlorocyclohexa-2,5-dien-1-ol + H2O => 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + chloride + H(+)"}
{"X":38455,"RHEA_ID":36683,"DIRECTION":"UN","MASTER_ID":36683,"ec":"2.3.1.225","compounds":"hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]"}
{"X":38456,"RHEA_ID":36684,"compounds":"hexadecanoyl-CoA + L-cysteinyl-[protein] => CoA + S-hexadecanoyl-L-cysteinyl-[protein]"}
{"X":38457,"RHEA_ID":36685,"compounds":"CoA + S-hexadecanoyl-L-cysteinyl-[protein] => hexadecanoyl-CoA + L-cysteinyl-[protein]"}
{"X":38458,"RHEA_ID":36687,"compounds":"hexadecanoyl-CoA + sphing-4-enine = CoA + H(+) + N-hexadecanoylsphing-4-enine"}
{"X":38459,"RHEA_ID":36688,"compounds":"hexadecanoyl-CoA + sphing-4-enine => CoA + H(+) + N-hexadecanoylsphing-4-enine"}
{"X":38460,"RHEA_ID":36689,"compounds":"CoA + H(+) + N-hexadecanoylsphing-4-enine => hexadecanoyl-CoA + sphing-4-enine"}
{"X":38461,"RHEA_ID":56633,"compounds":"H2O + neryl diphosphate => 1,8-cineole + diphosphate"}
{"X":38462,"RHEA_ID":36691,"compounds":"octadecanoyl-CoA + sphing-4-enine = CoA + H(+) + N-octadecanoylsphing-4-enine"}
{"X":38463,"RHEA_ID":36692,"compounds":"octadecanoyl-CoA + sphing-4-enine => CoA + H(+) + N-octadecanoylsphing-4-enine"}
{"X":38464,"RHEA_ID":36693,"compounds":"CoA + H(+) + N-octadecanoylsphing-4-enine => octadecanoyl-CoA + sphing-4-enine"}
{"X":38465,"RHEA_ID":46608,"DIRECTION":"UN","MASTER_ID":46608,"ec":"2.7.11.22","compounds":"ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]"}
{"X":38466,"RHEA_ID":36695,"DIRECTION":"UN","MASTER_ID":36695,"ec":"2.4.1.302","compounds":"dTDP-4-O-demethyl-beta-L-noviose + novobiocic acid = desmethyldescarbamoylnovobiocin + dTDP + H(+)"}
{"X":38467,"RHEA_ID":36696,"DIRECTION":"LR","MASTER_ID":36695,"metacyc":"RXN-14544","compounds":"dTDP-4-O-demethyl-beta-L-noviose + novobiocic acid => desmethyldescarbamoylnovobiocin + dTDP + H(+)"}
{"X":38468,"RHEA_ID":36697,"compounds":"desmethyldescarbamoylnovobiocin + dTDP + H(+) => dTDP-4-O-demethyl-beta-L-noviose + novobiocic acid"}
{"X":38469,"RHEA_ID":46610,"compounds":"ADP + H(+) + O-phospho-L-threonyl-[protein] => ATP + L-threonyl-[protein]"}
{"X":38470,"RHEA_ID":36699,"DIRECTION":"UN","MASTER_ID":36699,"ec":"6.3.1.15","compounds":"3-amino-4,7-dihydroxycoumarin + 3-dimethylallyl-4-hydroxybenzoate + ATP = 8-desmethylnovobiocic acid + AMP + diphosphate"}
{"X":38471,"RHEA_ID":36700,"DIRECTION":"LR","MASTER_ID":36699,"metacyc":"RXN-14547","compounds":"3-amino-4,7-dihydroxycoumarin + 3-dimethylallyl-4-hydroxybenzoate + ATP => 8-desmethylnovobiocic acid + AMP + diphosphate"}
{"X":38472,"RHEA_ID":36701,"compounds":"8-desmethylnovobiocic acid + AMP + diphosphate => 3-amino-4,7-dihydroxycoumarin + 3-dimethylallyl-4-hydroxybenzoate + ATP"}
{"X":38473,"RHEA_ID":56645,"compounds":"a uridine in mRNA => a pseudouridine in mRNA"}
{"X":38474,"RHEA_ID":36703,"DIRECTION":"UN","MASTER_ID":36703,"ec":"6.3.3.6","compounds":"(2S,5S)-5-carboxymethylproline + ATP = (3S,5S)-carbapenam-3-caboxylate + AMP + diphosphate + H(+)"}
{"X":38475,"RHEA_ID":36704,"DIRECTION":"LR","MASTER_ID":36703,"metacyc":"RXN-8948","compounds":"(2S,5S)-5-carboxymethylproline + ATP => (3S,5S)-carbapenam-3-caboxylate + AMP + diphosphate + H(+)"}
{"X":38476,"RHEA_ID":36705,"compounds":"(3S,5S)-carbapenam-3-caboxylate + AMP + diphosphate + H(+) => (2S,5S)-5-carboxymethylproline + ATP"}
{"X":38477,"RHEA_ID":60058,"compounds":"a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + 2 H2O + NAD(+) => a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H(+) + NADH + O2"}
{"X":38478,"RHEA_ID":36707,"DIRECTION":"UN","MASTER_ID":36707,"ec":"5.1.1.19","compounds":"O-ureido-L-serine = O-ureido-D-serine"}
{"X":38479,"RHEA_ID":36708,"compounds":"O-ureido-L-serine => O-ureido-D-serine"}
{"X":38480,"RHEA_ID":36709,"compounds":"O-ureido-D-serine => O-ureido-L-serine"}
{"X":38481,"RHEA_ID":56653,"compounds":"12alpha-hydroxy-3-oxocholan-24-oyl-CoA + NAD(+) => 12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH"}
{"X":38482,"RHEA_ID":36711,"DIRECTION":"UN","MASTER_ID":36711,"ec":"6.3.3.5","compounds":"ATP + H(+) + H2O + O-ureido-D-serine = ADP + CO2 + D-cycloserine + NH4(+) + phosphate"}
{"X":38483,"RHEA_ID":36712,"DIRECTION":"LR","MASTER_ID":36711,"metacyc":"RXN-14460","compounds":"ATP + H(+) + H2O + O-ureido-D-serine => ADP + CO2 + D-cycloserine + NH4(+) + phosphate"}
{"X":38484,"RHEA_ID":36713,"compounds":"ADP + CO2 + D-cycloserine + NH4(+) + phosphate => ATP + H(+) + H2O + O-ureido-D-serine"}
{"X":38485,"RHEA_ID":56657,"compounds":"12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NAD(+) => 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H(+) + NADH"}
{"X":38486,"RHEA_ID":36716,"compounds":"sphinganine + tetracosenoyl-CoA => CoA + H(+) + N-tetracosenoylsphinganine"}
{"X":38487,"RHEA_ID":36717,"compounds":"CoA + H(+) + N-tetracosenoylsphinganine => sphinganine + tetracosenoyl-CoA"}
{"X":38488,"RHEA_ID":36718,"compounds":"sphinganine + tetracosenoyl-CoA <=> CoA + H(+) + N-tetracosenoylsphinganine"}
{"X":38489,"RHEA_ID":46631,"compounds":"3beta-hydroxyandrost-5-en-17-one + H(+) + NADPH <=> androst-5-en-3beta,17beta-diol + NADP(+)"}
{"X":38490,"RHEA_ID":36720,"compounds":"hexacosenoyl-CoA + sphinganine => CoA + H(+) + N-hexacosenoylsphinganine"}
{"X":38491,"RHEA_ID":36721,"compounds":"CoA + H(+) + N-hexacosenoylsphinganine => hexacosenoyl-CoA + sphinganine"}
{"X":38492,"RHEA_ID":46634,"compounds":"7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NADP(+) => 7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + NADPH"}
{"X":38493,"RHEA_ID":36723,"compounds":"2-phenylethylamine + A + H2O = 2-phenylacetaldehyde + AH2 + NH4(+)"}
{"X":38494,"RHEA_ID":36724,"DIRECTION":"LR","MASTER_ID":36723,"metacyc":"RXN-11510","compounds":"2-phenylethylamine + A + H2O => 2-phenylacetaldehyde + AH2 + NH4(+)"}
{"X":38495,"RHEA_ID":36725,"compounds":"2-phenylacetaldehyde + AH2 + NH4(+) => 2-phenylethylamine + A + H2O"}
{"X":38496,"RHEA_ID":46638,"compounds":"H(+) + NADPH + testosterone => 5beta-dihydrotestosterone + NADP(+)"}
{"X":38497,"RHEA_ID":56670,"compounds":"7beta-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH => 7beta-hydroxy-3-oxochol-24-oyl-CoA + NAD(+)"}
{"X":38498,"RHEA_ID":36732,"compounds":"1-nitrocyclohexan + NADP(+) => 1-nitrocyclohexene + H(+) + NADPH"}
{"X":38499,"RHEA_ID":36733,"compounds":"1-nitrocyclohexene + H(+) + NADPH => 1-nitrocyclohexan + NADP(+)"}
{"X":38500,"RHEA_ID":36734,"compounds":"1-nitrocyclohexan + NADP(+) <=> 1-nitrocyclohexene + H(+) + NADPH"}
{"X":38501,"RHEA_ID":36739,"compounds":"heptadecasphing-4-enine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl-heptadecasphingosine"}
{"X":38502,"RHEA_ID":36740,"compounds":"heptadecasphing-4-enine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoyl-heptadecasphingosine"}
{"X":38503,"RHEA_ID":36741,"compounds":"CoA + H(+) + N-tetracosanoyl-heptadecasphingosine => heptadecasphing-4-enine + tetracosanoyl-CoA"}
{"X":38504,"RHEA_ID":46646,"compounds":"5beta-dihydrocortisol + NADP(+) => cortisol + H(+) + NADPH"}
{"X":38505,"RHEA_ID":46647,"compounds":"cortisol + H(+) + NADPH <=> 5beta-dihydrocortisol + NADP(+)"}
{"X":38506,"RHEA_ID":36744,"compounds":"heptadecasphing-4-enine + tetracosenoyl-CoA => CoA + H(+) + N-tetracosenoyl-heptadecasphingosine"}
{"X":38507,"RHEA_ID":36745,"compounds":"CoA + H(+) + N-tetracosenoyl-heptadecasphingosine => heptadecasphing-4-enine + tetracosenoyl-CoA"}
{"X":38508,"RHEA_ID":36746,"compounds":"heptadecasphing-4-enine + tetracosenoyl-CoA <=> CoA + H(+) + N-tetracosenoyl-heptadecasphingosine"}
{"X":38509,"RHEA_ID":36747,"DIRECTION":"UN","MASTER_ID":36747,"ec":"2.4.1.303","compounds":"N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UDP-alpha-D-galactose = beta-D-Gal-(1->3)-alpha-D-GlcNAc-diphospho-di-trans,octa-cis-undecaprenol + H(+) + UDP"}
{"X":38510,"RHEA_ID":36748,"compounds":"N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UDP-alpha-D-galactose => beta-D-Gal-(1->3)-alpha-D-GlcNAc-diphospho-di-trans,octa-cis-undecaprenol + H(+) + UDP"}
{"X":38511,"RHEA_ID":36749,"compounds":"beta-D-Gal-(1->3)-alpha-D-GlcNAc-diphospho-di-trans,octa-cis-undecaprenol + H(+) + UDP => N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UDP-alpha-D-galactose"}
{"X":38512,"RHEA_ID":56685,"DIRECTION":"LR","MASTER_ID":56684,"metacyc":"RXN-18802","compounds":"dihydrorhizobitoxine + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + rhizobitoxine"}
{"X":38513,"RHEA_ID":46655,"compounds":"epitestosterone + H(+) + NADPH <=> 5beta-dihydroepitestosterone + NADP(+)"}
{"X":38514,"RHEA_ID":36752,"compounds":"N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UDP-alpha-D-galactose => beta-D-Gal-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,octa-cis-undecaprenol + H(+) + UDP"}
{"X":38515,"RHEA_ID":36753,"compounds":"beta-D-Gal-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,octa-cis-undecaprenol + H(+) + UDP => N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UDP-alpha-D-galactose"}
{"X":38516,"RHEA_ID":56689,"DIRECTION":"LR","MASTER_ID":56688,"metacyc":"RXN-19262","compounds":"(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + O2 => (2E)-3-(4-hydroxyphenyl)-2-isocyanoprop-2-enoate + CO2 + H2O + succinate"}
{"X":38517,"RHEA_ID":46659,"compounds":"androst-4-ene-3,17-dione + H(+) + NADPH <=> 5beta-androstane-3,17-dione + NADP(+)"}
{"X":38518,"RHEA_ID":36756,"compounds":"N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UDP-alpha-D-glucose => beta-D-Glc-(1->3)-alpha-D-GlcNAc-diphospho-di-trans,octa-cis-undecaprenol + H(+) + UDP"}
{"X":38519,"RHEA_ID":36757,"compounds":"beta-D-Glc-(1->3)-alpha-D-GlcNAc-diphospho-di-trans,octa-cis-undecaprenol + H(+) + UDP => N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UDP-alpha-D-glucose"}
{"X":38520,"RHEA_ID":56693,"DIRECTION":"LR","MASTER_ID":56692,"metacyc":"RXN-19266","compounds":"(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 => 4-[(E)-2-isocyanoethenyl]phenol + 2 CO2 + H2O + succinate"}
{"X":38521,"RHEA_ID":46663,"compounds":"H(+) + NADPH + progesterone <=> 5beta-pregnan-3,20-dione + NADP(+)"}
{"X":38522,"RHEA_ID":36760,"DIRECTION":"LR","MASTER_ID":36759,"metacyc":"RXN-14560","compounds":"N-acetyl-alpha-D-galactosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UDP-N-acetyl-alpha-D-galactosamine => alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-di-trans,octa-cis-undecaprenol + H(+) + UDP"}
{"X":38523,"RHEA_ID":36761,"compounds":"alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-di-trans,octa-cis-undecaprenol + H(+) + UDP => N-acetyl-alpha-D-galactosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UDP-N-acetyl-alpha-D-galactosamine"}
{"X":38524,"RHEA_ID":56697,"DIRECTION":"LR","MASTER_ID":56696,"metacyc":"RXN-19264","compounds":"D-ribulose 5-phosphate + L-tryptophan => (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate"}
{"X":38525,"RHEA_ID":36763,"compounds":"alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-di-trans,octa-cis-undecaprenol + UDP-alpha-D-galactose = beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-di-trans,octa-cis-undecaprenol + H(+) + UDP"}
{"X":38526,"RHEA_ID":36764,"DIRECTION":"LR","MASTER_ID":36763,"metacyc":"RXN-14561","compounds":"alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-di-trans,octa-cis-undecaprenol + UDP-alpha-D-galactose => beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-di-trans,octa-cis-undecaprenol + H(+) + UDP"}
{"X":38527,"RHEA_ID":36765,"compounds":"beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-di-trans,octa-cis-undecaprenol + H(+) + UDP => alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-di-trans,octa-cis-undecaprenol + UDP-alpha-D-galactose"}
{"X":38528,"RHEA_ID":46670,"compounds":"5beta-dihydrodeoxycorticosterone + NADP(+) => 21-hydroxyprogesterone + H(+) + NADPH"}
{"X":38529,"RHEA_ID":46671,"compounds":"21-hydroxyprogesterone + H(+) + NADPH <=> 5beta-dihydrodeoxycorticosterone + NADP(+)"}
{"X":38530,"RHEA_ID":36768,"compounds":"2-hydroxytetracosenoyl-CoA + sphinganine => CoA + H(+) + N-(2-hydroxytetracosenoyl)-sphinganine"}
{"X":38531,"RHEA_ID":36769,"compounds":"CoA + H(+) + N-(2-hydroxytetracosenoyl)-sphinganine => 2-hydroxytetracosenoyl-CoA + sphinganine"}
{"X":38532,"RHEA_ID":36770,"compounds":"2-hydroxytetracosenoyl-CoA + sphinganine <=> CoA + H(+) + N-(2-hydroxytetracosenoyl)-sphinganine"}
{"X":38533,"RHEA_ID":46675,"compounds":"aldosterone + H(+) + NADPH <=> 5beta-dihydroaldosterone + NADP(+)"}
{"X":38534,"RHEA_ID":36772,"DIRECTION":"LR","MASTER_ID":36771,"metacyc":"RXN-14562","compounds":"beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-di-trans,octa-cis-undecaprenol + GDP-beta-L-fucose => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)"}
{"X":38535,"RHEA_ID":36773,"compounds":"alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+) => beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-di-trans,octa-cis-undecaprenol + GDP-beta-L-fucose"}
{"X":38536,"RHEA_ID":46678,"compounds":"(6R)-2,2,6-trimethyl-1,4-cyclohexanedione + H(+) + NADH => (4R)-hydroxy-(6R)-2,2,6-trimethylcyclohexanone + NAD(+)"}
{"X":38537,"RHEA_ID":56710,"compounds":"16alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":38538,"RHEA_ID":36776,"DIRECTION":"LR","MASTER_ID":36775,"metacyc":"RXN-14563","compounds":"alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-di-trans,octa-cis-undecaprenol + UDP-alpha-D-galactose => alpha-D-Gal-(1->3)-[alpha-L-Fuc-(1->2)]-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-di-trans,octa-cis-undecaprenol + H(+) + UDP"}
{"X":38539,"RHEA_ID":36777,"compounds":"alpha-D-Gal-(1->3)-[alpha-L-Fuc-(1->2)]-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-di-trans,octa-cis-undecaprenol + H(+) + UDP => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-di-trans,octa-cis-undecaprenol + UDP-alpha-D-galactose"}
{"X":38540,"RHEA_ID":46682,"compounds":"2 [Fe(II)-cytochrome b5] + H(+) + NAD(+) => 2 [Fe(III)-cytochrome b5] + NADH"}
{"X":38541,"RHEA_ID":56714,"compounds":"H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein]"}
{"X":38542,"RHEA_ID":36780,"compounds":"2-oxoglutarate + GDP-alpha-D-perosamine => GDP-4-dehydro-alpha-D-rhamnose + L-glutamate"}
{"X":38543,"RHEA_ID":36781,"compounds":"GDP-4-dehydro-alpha-D-rhamnose + L-glutamate => 2-oxoglutarate + GDP-alpha-D-perosamine"}
{"X":38544,"RHEA_ID":46686,"compounds":"(22E)-3-oxo-chol-4,22-dien-24-oyl-CoA + AH2 => 3-oxochol-4-en-24-oyl-CoA + A"}
{"X":38545,"RHEA_ID":56718,"compounds":"H(+) + S-disulfanyl-L-cysteinyl-[SoxY protein] + sulfate => H2O + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein]"}
{"X":38546,"RHEA_ID":36784,"DIRECTION":"LR","MASTER_ID":36783,"metacyc":"RXN-11371","compounds":"L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine => 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine"}
{"X":38547,"RHEA_ID":36785,"compounds":"2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine => L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine"}
{"X":38548,"RHEA_ID":46690,"compounds":"3-oxo-cholest-4,24-dien-26-oyl-CoA + AH2 => (25S)-3-oxocholest-4-en-26-oyl-CoA + A"}
{"X":38549,"RHEA_ID":56722,"compounds":"2 [Fe(II)cytochrome c] + 2 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein] => 2 [Fe(III)cytochrome c] + L-cysteinyl-[SoxY protein] + thiosulfate"}
{"X":38550,"RHEA_ID":36788,"compounds":"di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-galactosamine => N-acetyl-alpha-D-galactosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UMP"}
{"X":38551,"RHEA_ID":36789,"compounds":"N-acetyl-alpha-D-galactosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UMP => di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-galactosamine"}
{"X":38552,"RHEA_ID":46694,"compounds":"4-hydroxybenzoyl-5'-AMP + diphosphate => 4-hydroxybenzoate + ATP + H(+)"}
{"X":38553,"RHEA_ID":56726,"compounds":"4-hydroxy-all-trans-beta-carotene + A + H2O => AH2 + all-trans-beta-carotene + O2"}
{"X":38554,"RHEA_ID":36792,"DIRECTION":"LR","MASTER_ID":36791,"metacyc":"RXN-14457","compounds":"H2O + N(omega)-hydroxy-L-arginine => hydroxyurea + L-ornithine"}
{"X":38555,"RHEA_ID":36793,"compounds":"hydroxyurea + L-ornithine => H2O + N(omega)-hydroxy-L-arginine"}
{"X":38556,"RHEA_ID":46698,"compounds":"an N(1)-methylpseudouridine in 16S/18S rRNA + H(+) + S-adenosyl-L-homocysteine => a pseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine"}
{"X":38557,"RHEA_ID":56730,"compounds":"4,4-dihydroxy-all-trans-beta-carotene + A + H2O => 4-hydroxy-all-trans-beta-carotene + AH2 + O2"}
{"X":38558,"RHEA_ID":36796,"DIRECTION":"LR","MASTER_ID":36795,"metacyc":"RXN-14024","compounds":"a ribonucleoside 5'-triphosphate + 2 H2O => a ribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate"}
{"X":38559,"RHEA_ID":36797,"compounds":"a ribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate => a ribonucleoside 5'-triphosphate + 2 H2O"}
{"X":38560,"RHEA_ID":56734,"compounds":"echinenone + H2O => 4,4-dihydroxy-all-trans-beta-carotene"}
{"X":38561,"RHEA_ID":36800,"DIRECTION":"LR","MASTER_ID":36799,"ecocyc":"NUCLEOSIDE-DIPHOSPHATASE-RXN","compounds":"a ribonucleoside 5'-diphosphate + H2O => a ribonucleoside 5'-phosphate + H(+) + phosphate"}
{"X":38562,"RHEA_ID":36801,"compounds":"a ribonucleoside 5'-phosphate + H(+) + phosphate => a ribonucleoside 5'-diphosphate + H2O"}
{"X":38563,"RHEA_ID":46707,"compounds":"ATP + H(+) + salicylate <=> 2-hydroxybenzoyl-5'-AMP + diphosphate"}
{"X":38564,"RHEA_ID":36804,"DIRECTION":"LR","MASTER_ID":36803,"metacyc":"RXN-3303","compounds":"2-hydroxy-2,3-dihydrogenistein => genistein + H(+) + H2O"}
{"X":38565,"RHEA_ID":36805,"compounds":"genistein + H(+) + H2O => 2-hydroxy-2,3-dihydrogenistein"}
{"X":38566,"RHEA_ID":56741,"compounds":"globoside Gb3Cer + UDP-alpha-D-galactose => GalGb3Cer + H(+) + UDP"}
{"X":38567,"RHEA_ID":46711,"compounds":"2-hydroxybenzoyl-5'-AMP + holo-[ACP] <=> AMP + H(+) + salicyl-[ACP]"}
{"X":38568,"RHEA_ID":36808,"compounds":"H(+) + malonyl-CoA + octacosanoyl-CoA => 3-oxo-triacontanoyl-CoA + CO2 + CoA"}
{"X":38569,"RHEA_ID":36809,"compounds":"3-oxo-triacontanoyl-CoA + CO2 + CoA => H(+) + malonyl-CoA + octacosanoyl-CoA"}
{"X":38570,"RHEA_ID":36810,"compounds":"H(+) + malonyl-CoA + octacosanoyl-CoA <=> 3-oxo-triacontanoyl-CoA + CO2 + CoA"}
{"X":38571,"RHEA_ID":46715,"compounds":"pseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-homocysteine"}
{"X":38572,"RHEA_ID":36812,"compounds":"acetyl-CoA + GDP-alpha-D-perosamine => CoA + GDP-N-acetyl-alpha-D-perosamine + H(+)"}
{"X":38573,"RHEA_ID":36813,"compounds":"CoA + GDP-N-acetyl-alpha-D-perosamine + H(+) => acetyl-CoA + GDP-alpha-D-perosamine"}
{"X":38574,"RHEA_ID":46718,"compounds":"H(+) + N(1)-methylpseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-homocysteine => pseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-methionine"}
{"X":38575,"RHEA_ID":46719,"compounds":"pseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylpseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-homocysteine"}
{"X":38576,"RHEA_ID":36816,"compounds":"dTDP-alpha-D-fucose => dTDP-alpha-D-fucofuranose"}
{"X":38577,"RHEA_ID":36817,"compounds":"dTDP-alpha-D-fucofuranose => dTDP-alpha-D-fucose"}
{"X":38578,"RHEA_ID":46722,"compounds":"(2E)-hexenoyl-CoA + H2O => (3R)-hydroxyhexanoyl-CoA"}
{"X":38579,"RHEA_ID":46723,"compounds":"(3R)-hydroxyhexanoyl-CoA <=> (2E)-hexenoyl-CoA + H2O"}
{"X":38580,"RHEA_ID":36820,"compounds":"(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + CO2 + CoA"}
{"X":38581,"RHEA_ID":36821,"compounds":"3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + CO2 + CoA => (11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + malonyl-CoA"}
{"X":38582,"RHEA_ID":36822,"compounds":"(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + CO2 + CoA"}
{"X":38583,"RHEA_ID":46727,"compounds":"(2S)-2-methyltetradecanoyl-CoA <=> (2R)-2-methyltetradecanoyl-CoA"}
{"X":38584,"RHEA_ID":36824,"DIRECTION":"LR","MASTER_ID":36823,"metacyc":"RXN-14403","compounds":"1D-myo-inositol 3-phosphate + CDP-2,3-bis-(O-phytanyl)-sn-glycerol => CMP + H(+) + saturated 1-archaetidyl-1D-myo-inositol 3-phosphate"}
{"X":38585,"RHEA_ID":36825,"compounds":"CMP + H(+) + saturated 1-archaetidyl-1D-myo-inositol 3-phosphate => 1D-myo-inositol 3-phosphate + CDP-2,3-bis-(O-phytanyl)-sn-glycerol"}
{"X":38586,"RHEA_ID":46730,"compounds":"(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O2 => (25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + O2"}
{"X":38587,"RHEA_ID":46731,"compounds":"(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + O2 <=> (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O2"}
{"X":38588,"RHEA_ID":36828,"DIRECTION":"LR","MASTER_ID":36827,"metacyc":"RXN-14573","compounds":"dioscin + 3 H2O => D-glucose + diosgenin + 2 L-rhamnopyranose"}
{"X":38589,"RHEA_ID":36829,"compounds":"D-glucose + diosgenin + 2 L-rhamnopyranose => dioscin + 3 H2O"}
{"X":38590,"RHEA_ID":46734,"compounds":"(2S,6)-dimethylheptanoyl-CoA => (2R,6)-dimethylheptanoyl-CoA"}
{"X":38591,"RHEA_ID":46735,"compounds":"(2R,6)-dimethylheptanoyl-CoA <=> (2S,6)-dimethylheptanoyl-CoA"}
{"X":38592,"RHEA_ID":36832,"DIRECTION":"LR","MASTER_ID":36831,"metacyc":"TRANS-RXN-240","compounds":"2 caldariellaquinol + n H(+)(in) + O2 => 2 caldariellaquinone + n H(+)(out) + 2 H2O"}
{"X":38593,"RHEA_ID":36833,"compounds":"2 caldariellaquinone + n H(+)(out) + 2 H2O => 2 caldariellaquinol + n H(+)(in) + O2"}
{"X":38594,"RHEA_ID":46738,"compounds":"a monoacylglycerol + phosphate => H2O + monoacyl-sn-glycero-3-phosphate"}
{"X":38595,"RHEA_ID":46739,"compounds":"H2O + monoacyl-sn-glycero-3-phosphate <=> a monoacylglycerol + phosphate"}
{"X":38596,"RHEA_ID":36836,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}
{"X":38597,"RHEA_ID":36837,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)"}
{"X":38598,"RHEA_ID":36838,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}
{"X":38599,"RHEA_ID":46743,"compounds":"cholesta-5,7,24-trien-3beta-ol + H(+) + NADPH <=> cholesta-5,24-dien-3beta-ol + NADP(+)"}
{"X":38600,"RHEA_ID":36840,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}
{"X":38601,"RHEA_ID":36841,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)"}
{"X":38602,"RHEA_ID":36842,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}
{"X":38603,"RHEA_ID":56778,"compounds":"(+)-piperitol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (+)-pinoresinol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":38604,"RHEA_ID":36844,"compounds":"(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + CO2 + CoA"}
{"X":38605,"RHEA_ID":36845,"compounds":"3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + CO2 + CoA => (13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + malonyl-CoA"}
{"X":38606,"RHEA_ID":36846,"compounds":"(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + CO2 + CoA"}
{"X":38607,"RHEA_ID":56782,"compounds":"(+)-sesamin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (+)-piperitol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":38608,"RHEA_ID":36848,"compounds":"FAD + L-threonyl-[protein] => AMP + FMN-L-threonyl-[protein] + H(+)"}
{"X":38609,"RHEA_ID":36849,"compounds":"AMP + FMN-L-threonyl-[protein] + H(+) => FAD + L-threonyl-[protein]"}
{"X":38610,"RHEA_ID":46754,"compounds":"7alpha,12alpha-dihydroxycholest-4-en-3-one + 2 [Fe(III)-cytochrome b5] + H2O => 7alpha-hydroxycholest-4-en-3-one + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}
{"X":38611,"RHEA_ID":40172,"compounds":"dodecanoyl-CoA + O2 => (2E)-dodecenoyl-CoA + H2O2"}
{"X":38612,"RHEA_ID":36852,"compounds":"(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + CO2 + CoA"}
{"X":38613,"RHEA_ID":36853,"compounds":"3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + CO2 + CoA => (15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + malonyl-CoA"}
{"X":38614,"RHEA_ID":36854,"compounds":"(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + CO2 + CoA"}
{"X":38615,"RHEA_ID":36855,"DIRECTION":"UN","MASTER_ID":36855,"ec":"3.5.1.14","compounds":"an N-acetyl-L-cysteine-S-conjugate + H2O = acetate + an S-substituted L-cysteine"}
{"X":38616,"RHEA_ID":36855,"DIRECTION":"UN","MASTER_ID":36855,"ec":"3.5.1.114","compounds":"an N-acetyl-L-cysteine-S-conjugate + H2O = acetate + an S-substituted L-cysteine"}
{"X":38617,"RHEA_ID":36856,"compounds":"an N-acetyl-L-cysteine-S-conjugate + H2O => acetate + an S-substituted L-cysteine"}
{"X":38618,"RHEA_ID":36857,"compounds":"acetate + an S-substituted L-cysteine => an N-acetyl-L-cysteine-S-conjugate + H2O"}
{"X":38619,"RHEA_ID":40180,"compounds":"decanoyl-CoA + O2 => (2E)-decenoyl-CoA + H2O2"}
{"X":38620,"RHEA_ID":36859,"compounds":"(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + CO2 + CoA"}
{"X":38621,"RHEA_ID":36860,"compounds":"(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + CO2 + CoA"}
{"X":38622,"RHEA_ID":36861,"compounds":"3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + CO2 + CoA => (17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + malonyl-CoA"}
{"X":38623,"RHEA_ID":56798,"compounds":"adenosylcob(III)alamin + apo-[corrinoid adenosyltransferase] + triphosphate => [corrinoid adenosyltransferase]-cob(I)alamin + ATP"}
{"X":38624,"RHEA_ID":36863,"compounds":"(9Z)-octadecenoyl-CoA + AH2 + O2 = (9Z,12Z)-octadecadienoyl-CoA + A + 2 H2O"}
{"X":38625,"RHEA_ID":36864,"compounds":"(9Z)-octadecenoyl-CoA + AH2 + O2 => (9Z,12Z)-octadecadienoyl-CoA + A + 2 H2O"}
{"X":38626,"RHEA_ID":36865,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + A + 2 H2O => (9Z)-octadecenoyl-CoA + AH2 + O2"}
{"X":38627,"RHEA_ID":56802,"compounds":"cob(II)yrinate a,c diamide--[corrinoid adenosyltransferase] => apo-[corrinoid adenosyltransferase] + cob(II)yrinate a,c diamide"}
{"X":38628,"RHEA_ID":36867,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AH2 + O2 = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + A + 2 H2O"}
{"X":38629,"RHEA_ID":36868,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AH2 + O2 => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + A + 2 H2O"}
{"X":38630,"RHEA_ID":36869,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + A + 2 H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AH2 + O2"}
{"X":38631,"RHEA_ID":56806,"compounds":"2 cob(I)yrinate a,c diamide--[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein] => 2 cob(II)yrinate a,c diamide--[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein]"}
{"X":38632,"RHEA_ID":36871,"compounds":"(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + CO2 + CoA"}
{"X":38633,"RHEA_ID":36872,"compounds":"(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + CO2 + CoA"}
{"X":38634,"RHEA_ID":36873,"compounds":"3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + CO2 + CoA => (19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + malonyl-CoA"}
{"X":38635,"RHEA_ID":46778,"compounds":"a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":38636,"RHEA_ID":36875,"compounds":"(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + CO2 + CoA"}
{"X":38637,"RHEA_ID":36876,"compounds":"(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + CO2 + CoA"}
{"X":38638,"RHEA_ID":36877,"compounds":"3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + CO2 + CoA => (21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + malonyl-CoA"}
{"X":38639,"RHEA_ID":56814,"compounds":"4-chloro-L-threonyl-[peptidyl-carrier protein] + CO2 + H2O + succinate => 2-oxoglutarate + chloride + H(+) + L-threonyl-[peptidyl-carrier protein] + O2"}
{"X":38640,"RHEA_ID":36879,"compounds":"(8Z,11Z,14Z)-eicosatrienoyl-CoA + AH2 + O2 = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + A + 2 H2O"}
{"X":38641,"RHEA_ID":36880,"compounds":"(8Z,11Z,14Z)-eicosatrienoyl-CoA + AH2 + O2 => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + A + 2 H2O"}
{"X":38642,"RHEA_ID":36881,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + A + 2 H2O => (8Z,11Z,14Z)-eicosatrienoyl-CoA + AH2 + O2"}
{"X":38643,"RHEA_ID":46786,"compounds":"a 1-[(9Z,12Z,15Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":38644,"RHEA_ID":36883,"compounds":"(8Z,11Z,14Z)-eicosatrienoyl-CoA + AH2 + O2 = (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + A + 2 H2O"}
{"X":38645,"RHEA_ID":36884,"compounds":"(8Z,11Z,14Z)-eicosatrienoyl-CoA + AH2 + O2 => (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + A + 2 H2O"}
{"X":38646,"RHEA_ID":36885,"compounds":"(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + A + 2 H2O => (8Z,11Z,14Z)-eicosatrienoyl-CoA + AH2 + O2"}
{"X":38647,"RHEA_ID":46790,"compounds":"a 1-[(6Z,9Z,12Z,15Z)-octadectetraenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":38648,"RHEA_ID":36887,"compounds":"(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + AH2 + O2 = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + A + 2 H2O"}
{"X":38649,"RHEA_ID":36888,"compounds":"(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + AH2 + O2 => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + A + 2 H2O"}
{"X":38650,"RHEA_ID":36889,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + A + 2 H2O => (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + AH2 + O2"}
{"X":38651,"RHEA_ID":56826,"compounds":"A + cyclooctatin + H2O => AH2 + cyclooctat-9-ene-5,7-diol + O2"}
{"X":38652,"RHEA_ID":36891,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + AH2 + O2 = (9Z,12Z,15Z)-octadecatrienoyl-CoA + A + 2 H2O"}
{"X":38653,"RHEA_ID":36892,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + AH2 + O2 => (9Z,12Z,15Z)-octadecatrienoyl-CoA + A + 2 H2O"}
{"X":38654,"RHEA_ID":36893,"compounds":"(9Z,12Z,15Z)-octadecatrienoyl-CoA + A + 2 H2O => (9Z,12Z)-octadecadienoyl-CoA + AH2 + O2"}
{"X":38655,"RHEA_ID":46798,"compounds":"2 [Fe(III)-cytochrome b5] + an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 H2O => 2 [Fe(II)-cytochrome b5] + an (11Z,14Z,17Z)-icosatrienoyl-containing glycerolipid + 2 H(+) + O2"}
{"X":38656,"RHEA_ID":36895,"compounds":"(9Z,12Z,15Z)-octadecatrienoyl-CoA + AH2 + O2 = (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + A + 2 H2O"}
{"X":38657,"RHEA_ID":36896,"compounds":"(9Z,12Z,15Z)-octadecatrienoyl-CoA + AH2 + O2 => (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + A + 2 H2O"}
{"X":38658,"RHEA_ID":36897,"compounds":"(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + A + 2 H2O => (9Z,12Z,15Z)-octadecatrienoyl-CoA + AH2 + O2"}
{"X":38659,"RHEA_ID":56834,"DIRECTION":"RL","MASTER_ID":56832,"metacyc":"TECH2REDHAL-RXN","compounds":"2,3,6-trichlorohydroquinone + 2 glutathione => 2,6-dichlorohydroquinone + chloride + glutathione disulfide + H(+)"}
{"X":38660,"RHEA_ID":36899,"DIRECTION":"UN","MASTER_ID":36899,"ec":"2.1.1.228","compounds":"guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine"}
{"X":38661,"RHEA_ID":36900,"DIRECTION":"LR","MASTER_ID":36899,"ecocyc":"RXN-12458","metacyc":"RXN-12458","compounds":"guanosine(37) in tRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine"}
{"X":38662,"RHEA_ID":36901,"compounds":"H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine => guanosine(37) in tRNA + S-adenosyl-L-methionine"}
{"X":38663,"RHEA_ID":40224,"compounds":"4,8-dimethylnonanoyl-CoA + H2O => 4,8-dimethylnonanoate + CoA + H(+)"}
{"X":38664,"RHEA_ID":36903,"DIRECTION":"UN","MASTER_ID":36903,"ec":"2.1.1.290","compounds":"7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine"}
{"X":38665,"RHEA_ID":36904,"DIRECTION":"LR","MASTER_ID":36903,"metacyc":"RXN-14528","compounds":"7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine => 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine"}
{"X":38666,"RHEA_ID":50200,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O"}
{"X":38667,"RHEA_ID":40228,"compounds":"3'-phosphoadenylyl sulfate + desulfo-A47934 => A47934 + adenosine 3',5'-bisphosphate + H(+)"}
{"X":38668,"RHEA_ID":36907,"compounds":"(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + malonyl-CoA = (13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + CO2 + CoA"}
{"X":38669,"RHEA_ID":36908,"compounds":"(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + malonyl-CoA => (13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + CO2 + CoA"}
{"X":38670,"RHEA_ID":36909,"compounds":"(13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + CO2 + CoA => (11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + malonyl-CoA"}
{"X":38671,"RHEA_ID":56846,"compounds":"nocamycin I + S-adenosyl-L-homocysteine => nocamycin E + S-adenosyl-L-methionine"}
{"X":38672,"RHEA_ID":36911,"compounds":"(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + CO2 + CoA"}
{"X":38673,"RHEA_ID":36912,"compounds":"(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + CO2 + CoA"}
{"X":38674,"RHEA_ID":36913,"compounds":"3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + CO2 + CoA => (13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + H(+) + malonyl-CoA"}
{"X":38675,"RHEA_ID":46818,"compounds":"4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O => 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}
{"X":38676,"RHEA_ID":36915,"compounds":"(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + CO2 + CoA"}
{"X":38677,"RHEA_ID":36916,"compounds":"(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + CO2 + CoA"}
{"X":38678,"RHEA_ID":36917,"compounds":"3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + CO2 + CoA => (15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + malonyl-CoA"}
{"X":38679,"RHEA_ID":46822,"compounds":"4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}
{"X":38680,"RHEA_ID":36919,"compounds":"(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + CO2 + CoA"}
{"X":38681,"RHEA_ID":36920,"compounds":"(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + CO2 + CoA"}
{"X":38682,"RHEA_ID":36921,"compounds":"3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + CO2 + CoA => (17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + malonyl-CoA"}
{"X":38683,"RHEA_ID":36922,"compounds":"(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + CO2 + CoA"}
{"X":38684,"RHEA_ID":36923,"compounds":"(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + CO2 + CoA"}
{"X":38685,"RHEA_ID":36924,"compounds":"(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + CO2 + CoA"}
{"X":38686,"RHEA_ID":36925,"compounds":"3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + CO2 + CoA => (19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + malonyl-CoA"}
{"X":38687,"RHEA_ID":46830,"compounds":"4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADPH => 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+)"}
{"X":38688,"RHEA_ID":36927,"compounds":"(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + CO2 + CoA"}
{"X":38689,"RHEA_ID":36928,"compounds":"(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + CO2 + CoA"}
{"X":38690,"RHEA_ID":36929,"compounds":"3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + CO2 + CoA => (21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + malonyl-CoA"}
{"X":38691,"RHEA_ID":56865,"DIRECTION":"LR","MASTER_ID":56864,"metacyc":"RXN-18628","compounds":"12 H(+) + 6 malonyl-CoA + NADH + 5 NADPH => (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + 6 CO2 + 6 CoA + 4 H2O + NAD(+) + 5 NADP(+)"}
{"X":38692,"RHEA_ID":36931,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 = (9Z)-hexadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":38693,"RHEA_ID":36932,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 => (9Z)-hexadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":38694,"RHEA_ID":36933,"compounds":"(9Z)-hexadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => 2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2"}
{"X":38695,"RHEA_ID":56869,"DIRECTION":"LR","MASTER_ID":56868,"metacyc":"RXN-19396","compounds":"(2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + octanoyl-CoA => (2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + CoA"}
{"X":38696,"RHEA_ID":36935,"compounds":"(11E)-octadecenoyl-CoA + AH2 + O2 = (9Z,11E)-octadecadienoyl-CoA + A + 2 H2O"}
{"X":38697,"RHEA_ID":36936,"compounds":"(11E)-octadecenoyl-CoA + AH2 + O2 => (9Z,11E)-octadecadienoyl-CoA + A + 2 H2O"}
{"X":38698,"RHEA_ID":36937,"compounds":"(9Z,11E)-octadecadienoyl-CoA + A + 2 H2O => (11E)-octadecenoyl-CoA + AH2 + O2"}
{"X":38699,"RHEA_ID":36938,"compounds":"(11E)-octadecenoyl-CoA + AH2 + O2 <=> (9Z,11E)-octadecadienoyl-CoA + A + 2 H2O"}
{"X":38700,"RHEA_ID":36939,"compounds":"AH2 + O2 + tetradecanoyl-CoA = (9Z)-tetradecenoyl-CoA + A + 2 H2O"}
{"X":38701,"RHEA_ID":36940,"compounds":"AH2 + O2 + tetradecanoyl-CoA => (9Z)-tetradecenoyl-CoA + A + 2 H2O"}
{"X":38702,"RHEA_ID":36941,"compounds":"(9Z)-tetradecenoyl-CoA + A + 2 H2O => AH2 + O2 + tetradecanoyl-CoA"}
{"X":38703,"RHEA_ID":46846,"compounds":"4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O => 4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2"}
{"X":38704,"RHEA_ID":36943,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CO2 + CoA"}
{"X":38705,"RHEA_ID":36944,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CO2 + CoA"}
{"X":38706,"RHEA_ID":36945,"compounds":"3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CO2 + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + malonyl-CoA"}
{"X":38707,"RHEA_ID":56881,"compounds":"a 3beta-hydroxy-Delta(5)-steroid + NADP(+) => a 3-oxo-Delta(5)-steroid + H(+) + NADPH"}
{"X":38708,"RHEA_ID":36947,"compounds":"(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + CO2 + CoA"}
{"X":38709,"RHEA_ID":36948,"compounds":"(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + CO2 + CoA"}
{"X":38710,"RHEA_ID":36949,"compounds":"3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + CO2 + CoA => (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + malonyl-CoA"}
{"X":38711,"RHEA_ID":56885,"compounds":"adenosine(32) in tRNA + S-adenosyl-L-methionine => 2'-O-methyladenosine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":38712,"RHEA_ID":36951,"compounds":"AH2 + heptadecanoyl-CoA + O2 = (9Z)-heptadecenoyl-CoA + A + 2 H2O"}
{"X":38713,"RHEA_ID":36952,"compounds":"AH2 + heptadecanoyl-CoA + O2 => (9Z)-heptadecenoyl-CoA + A + 2 H2O"}
{"X":38714,"RHEA_ID":36953,"compounds":"(9Z)-heptadecenoyl-CoA + A + 2 H2O => AH2 + heptadecanoyl-CoA + O2"}
{"X":38715,"RHEA_ID":56889,"compounds":"UDP-4-dehydro-6-deoxy-alpha-D-glucose => UDP-4-dehydro-beta-L-rhamnose"}
{"X":38716,"RHEA_ID":36955,"compounds":"AH2 + O2 + pentadecanoyl-CoA = (9Z)-pentadecenoyl-CoA + A + 2 H2O"}
{"X":38717,"RHEA_ID":36956,"compounds":"AH2 + O2 + pentadecanoyl-CoA => (9Z)-pentadecenoyl-CoA + A + 2 H2O"}
{"X":38718,"RHEA_ID":36957,"compounds":"(9Z)-pentadecenoyl-CoA + A + 2 H2O => AH2 + O2 + pentadecanoyl-CoA"}
{"X":38719,"RHEA_ID":46866,"compounds":"a 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid A (E. coli)"}
{"X":38720,"RHEA_ID":36959,"compounds":"D-ribono-1,4-lactone + H(+) + NADH = D-ribose + NAD(+)"}
{"X":38721,"RHEA_ID":36960,"compounds":"D-ribono-1,4-lactone + H(+) + NADH => D-ribose + NAD(+)"}
{"X":38722,"RHEA_ID":36961,"compounds":"D-ribose + NAD(+) => D-ribono-1,4-lactone + H(+) + NADH"}
{"X":38723,"RHEA_ID":36962,"compounds":"D-ribono-1,4-lactone + H(+) + NADH <=> D-ribose + NAD(+)"}
{"X":38724,"RHEA_ID":36963,"compounds":"(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + CO2 + CoA"}
{"X":38725,"RHEA_ID":36964,"compounds":"(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + CO2 + CoA"}
{"X":38726,"RHEA_ID":36965,"compounds":"3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + CO2 + CoA => (8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + malonyl-CoA"}
{"X":38727,"RHEA_ID":36966,"compounds":"(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + CO2 + CoA"}
{"X":38728,"RHEA_ID":36967,"compounds":"(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + CO2 + CoA"}
{"X":38729,"RHEA_ID":36968,"compounds":"(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + CO2 + CoA"}
{"X":38730,"RHEA_ID":36969,"compounds":"3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + CO2 + CoA => (10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + malonyl-CoA"}
{"X":38731,"RHEA_ID":46878,"compounds":"[(1->4)-beta-D-mannuronosyl](n+1) + GDP + H(+) => [(1->4)-beta-D-mannuronosyl](n) + GDP-alpha-D-mannuronate"}
{"X":38732,"RHEA_ID":56906,"compounds":"AMP + an acyl-CoA + H(+) => an acyl-AMP + CoA"}
{"X":38733,"RHEA_ID":36972,"DIRECTION":"LR","MASTER_ID":36971,"metacyc":"RXN-14707","compounds":"dTDP-4-dehydro-6-deoxy-alpha-D-glucose => dTDP-4-dehydro-6-deoxy-alpha-D-allose"}
{"X":38734,"RHEA_ID":36973,"compounds":"dTDP-4-dehydro-6-deoxy-alpha-D-allose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose"}
{"X":38735,"RHEA_ID":56909,"DIRECTION":"LR","MASTER_ID":56908,"metacyc":"RXN-8144","compounds":"(7S)-O-acetylsalutaridinol => acetate + H(+) + thebaine"}
{"X":38736,"RHEA_ID":36976,"DIRECTION":"LR","MASTER_ID":36975,"metacyc":"RXN-8800","compounds":"AMP + phosphate => adenine + alpha-D-ribose 1,5-bisphosphate"}
{"X":38737,"RHEA_ID":36977,"compounds":"adenine + alpha-D-ribose 1,5-bisphosphate => AMP + phosphate"}
{"X":38738,"RHEA_ID":36978,"compounds":"AMP + phosphate <=> adenine + alpha-D-ribose 1,5-bisphosphate"}
{"X":38739,"RHEA_ID":36980,"compounds":"(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + CO2 + CoA"}
{"X":38740,"RHEA_ID":36981,"compounds":"3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + CO2 + CoA => (12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + malonyl-CoA"}
{"X":38741,"RHEA_ID":46890,"compounds":"3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + H2O2 => 3-deoxy-alpha-D-manno-oct-2-ulosonate + O2"}
{"X":38742,"RHEA_ID":36983,"compounds":"(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + CO2 + CoA"}
{"X":38743,"RHEA_ID":36984,"compounds":"(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + CO2 + CoA"}
{"X":38744,"RHEA_ID":36985,"compounds":"3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + CO2 + CoA => (14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + malonyl-CoA"}
{"X":38745,"RHEA_ID":46894,"compounds":"3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + L-glutamate => 2-oxoglutarate + 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate"}
{"X":38746,"RHEA_ID":36987,"DIRECTION":"UN","MASTER_ID":36987,"ec":"2.4.2.57","compounds":"CMP + phosphate = alpha-D-ribose 1,5-bisphosphate + cytosine"}
{"X":38747,"RHEA_ID":36988,"compounds":"CMP + phosphate => alpha-D-ribose 1,5-bisphosphate + cytosine"}
{"X":38748,"RHEA_ID":36989,"compounds":"alpha-D-ribose 1,5-bisphosphate + cytosine => CMP + phosphate"}
{"X":38749,"RHEA_ID":46898,"compounds":"a 1,2-diacyl-sn-glycerol + lipid A hexaacyl 1-(2-aminoethyl diphosphate) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli)"}
{"X":38750,"RHEA_ID":36992,"compounds":"phosphate + UMP => alpha-D-ribose 1,5-bisphosphate + uracil"}
{"X":38751,"RHEA_ID":36993,"compounds":"alpha-D-ribose 1,5-bisphosphate + uracil => phosphate + UMP"}
{"X":38752,"RHEA_ID":46902,"compounds":"a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate) (E. coli) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli)"}
{"X":38753,"RHEA_ID":36996,"compounds":"(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + CO2 + CoA"}
{"X":38754,"RHEA_ID":36997,"compounds":"3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + CO2 + CoA => (16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + malonyl-CoA"}
{"X":38755,"RHEA_ID":46906,"compounds":"a 1,2-diacyl-sn-glycerol + lipid A 1,4'-bis(2-aminoethyl diphosphate) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A hexaacyl 1-(2-aminoethyl diphosphate)"}
{"X":38756,"RHEA_ID":36999,"compounds":"(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":38757,"RHEA_ID":37000,"compounds":"(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":38758,"RHEA_ID":37001,"compounds":"(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}
{"X":38759,"RHEA_ID":46910,"compounds":"7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + a 1,2-diacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA"}
{"X":38760,"RHEA_ID":37004,"compounds":"(11Z,14Z,17Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(13Z,16Z,19Z)-docosatrienoyl-CoA + CO2 + CoA"}
{"X":38761,"RHEA_ID":37005,"compounds":"3-oxo-(13Z,16Z,19Z)-docosatrienoyl-CoA + CO2 + CoA => (11Z,14Z,17Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA"}
{"X":38762,"RHEA_ID":46914,"compounds":"H(+) + juvenile hormone III carboxylate + methanol => H2O + juvenile hormone III"}
{"X":38763,"RHEA_ID":37007,"compounds":"(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + CO2 + CoA"}
{"X":38764,"RHEA_ID":37008,"compounds":"(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + CO2 + CoA"}
{"X":38765,"RHEA_ID":37009,"compounds":"3-oxo-(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + CO2 + CoA => (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA"}
{"X":38766,"RHEA_ID":37010,"compounds":"(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + CO2 + CoA"}
{"X":38767,"RHEA_ID":37011,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) = a 1-acyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}
{"X":38768,"RHEA_ID":37012,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) => a 1-acyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}
{"X":38769,"RHEA_ID":37013,"compounds":"a 1-acyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol)"}
{"X":38770,"RHEA_ID":37014,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> a 1-acyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}
{"X":38771,"RHEA_ID":56950,"compounds":"H(+) + phosphoenolpyruvate + UDP => pyruvate + UTP"}
{"X":38772,"RHEA_ID":37016,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) => a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}
{"X":38773,"RHEA_ID":37017,"compounds":"a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol)"}
{"X":38774,"RHEA_ID":37018,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}
{"X":38775,"RHEA_ID":56954,"compounds":"CDP + H(+) + phosphoenolpyruvate => CTP + pyruvate"}
{"X":38776,"RHEA_ID":37020,"compounds":"A + D-serine + H2O => 3-hydroxypyruvate + AH2 + NH4(+)"}
{"X":38777,"RHEA_ID":37021,"compounds":"3-hydroxypyruvate + AH2 + NH4(+) => A + D-serine + H2O"}
{"X":38778,"RHEA_ID":37022,"compounds":"A + D-serine + H2O <=> 3-hydroxypyruvate + AH2 + NH4(+)"}
{"X":38779,"RHEA_ID":37023,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 = (6Z)-hexadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":38780,"RHEA_ID":37024,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 => (6Z)-hexadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":38781,"RHEA_ID":37025,"compounds":"(6Z)-hexadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => 2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2"}
{"X":38782,"RHEA_ID":37026,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 <=> (6Z)-hexadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":38783,"RHEA_ID":37031,"compounds":"D-ribonate = 2-dehydro-3-deoxy-D-arabinonate + H2O"}
{"X":38784,"RHEA_ID":37032,"compounds":"D-ribonate => 2-dehydro-3-deoxy-D-arabinonate + H2O"}
{"X":38785,"RHEA_ID":46937,"compounds":"(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) => ATP + H(+) + L-2-aminoadipate + NADPH"}
{"X":38786,"RHEA_ID":37034,"compounds":"D-ribonate <=> 2-dehydro-3-deoxy-D-arabinonate + H2O"}
{"X":38787,"RHEA_ID":37035,"compounds":"H2O + L-2-aminopentanoate + NAD(+) = 2-oxopentanoate + H(+) + NADH + NH4(+)"}
{"X":38788,"RHEA_ID":37036,"compounds":"H2O + L-2-aminopentanoate + NAD(+) => 2-oxopentanoate + H(+) + NADH + NH4(+)"}
{"X":38789,"RHEA_ID":46941,"compounds":"AMP + diphosphate + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] => ATP + holo-[LYS2 peptidyl-carrier protein] + L-2-aminoadipate"}
{"X":38790,"RHEA_ID":37038,"compounds":"H2O + L-2-aminopentanoate + NAD(+) <=> 2-oxopentanoate + H(+) + NADH + NH4(+)"}
{"X":38791,"RHEA_ID":37039,"DIRECTION":"UN","MASTER_ID":37039,"ec":"1.14.99.48","compounds":"5 AH2 + 2 H(+) + heme b + 4 O2 = 5 A + delta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O"}
{"X":38792,"RHEA_ID":37040,"DIRECTION":"LR","MASTER_ID":37039,"metacyc":"RXN-14696","compounds":"5 AH2 + 2 H(+) + heme b + 4 O2 => 5 A + delta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O"}
{"X":38793,"RHEA_ID":46945,"compounds":"(S)-2-amino-6-oxohexanoate + holo-[LYS2 peptidyl-carrier protein] + NADP(+) => H(+) + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] + NADPH"}
{"X":38794,"RHEA_ID":46946,"DIRECTION":"RL","MASTER_ID":46944,"metacyc":"RXN-16758","compounds":"H(+) + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] + NADPH => (S)-2-amino-6-oxohexanoate + holo-[LYS2 peptidyl-carrier protein] + NADP(+)"}
{"X":38795,"RHEA_ID":46947,"compounds":"(S)-2-amino-6-oxohexanoate + holo-[LYS2 peptidyl-carrier protein] + NADP(+) <=> H(+) + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] + NADPH"}
{"X":38796,"RHEA_ID":37044,"compounds":"ATP + H2O + L-alanyl-L-glutamate(out) => ADP + H(+) + L-alanyl-L-glutamate(in) + phosphate"}
{"X":38797,"RHEA_ID":46949,"compounds":"GTP + S-adenosyl-L-methionine => 7-methyl-GTP + S-adenosyl-L-homocysteine"}
{"X":38798,"RHEA_ID":37046,"compounds":"ATP + H2O + L-alanyl-L-glutamate(out) <=> ADP + H(+) + L-alanyl-L-glutamate(in) + phosphate"}
{"X":38799,"RHEA_ID":46951,"compounds":"GTP + S-adenosyl-L-methionine <=> 7-methyl-GTP + S-adenosyl-L-homocysteine"}
{"X":38800,"RHEA_ID":37048,"DIRECTION":"LR","MASTER_ID":37047,"reactome":"R-HSA-428007.1","compounds":"H(+)(out) + L-histidine(out) => H(+)(in) + L-histidine(in)"}
{"X":38801,"RHEA_ID":46953,"compounds":"2 formate + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 CO2 + H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":38802,"RHEA_ID":37050,"compounds":"H(+)(out) + L-histidine(out) <=> H(+)(in) + L-histidine(in)"}
{"X":38803,"RHEA_ID":37052,"compounds":"3-deacetyl-3-vinylbacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate => ATP + chlorophyllide a + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":38804,"RHEA_ID":46957,"compounds":"hydrocaffeoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] => (E)-caffeoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":38805,"RHEA_ID":46958,"compounds":"(E)-caffeoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin] => hydrocaffeoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":38806,"RHEA_ID":46959,"DIRECTION":"BI","MASTER_ID":46956,"metacyc":"RXN-16702","compounds":"hydrocaffeoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> (E)-caffeoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":38807,"RHEA_ID":37056,"DIRECTION":"LR","MASTER_ID":37055,"metacyc":"RXN-14631","compounds":"3-(4-hydroxyphenyl)pyruvate + dimethylallyl diphosphate => 3-dimethylallyl-4-hydroxyphenylpyruvate + diphosphate"}
{"X":38808,"RHEA_ID":37057,"compounds":"3-dimethylallyl-4-hydroxyphenylpyruvate + diphosphate => 3-(4-hydroxyphenyl)pyruvate + dimethylallyl diphosphate"}
{"X":38809,"RHEA_ID":46962,"DIRECTION":"RL","MASTER_ID":46960,"metacyc":"RXN-12558","compounds":"(2E)-butenoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin] => butanoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":38810,"RHEA_ID":56990,"compounds":"6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":38811,"RHEA_ID":37060,"compounds":"adenosine(37) in tRNA + L-threonylcarbamoyladenylate => AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA"}
{"X":38812,"RHEA_ID":46965,"DIRECTION":"LR","MASTER_ID":46964,"metacyc":"RXN-16836","compounds":"lactate + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] => 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate"}
{"X":38813,"RHEA_ID":37062,"DIRECTION":"BI","MASTER_ID":37059,"metacyc":"RXN-14570","compounds":"adenosine(37) in tRNA + L-threonylcarbamoyladenylate <=> AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA"}
{"X":38814,"RHEA_ID":37064,"DIRECTION":"LR","MASTER_ID":37063,"ecocyc":"RXN-14481","metacyc":"RXN-14481","compounds":"2-sulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine => 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":38815,"RHEA_ID":46969,"compounds":"A + dihydroisopentenyldehydrorhodopin => AH2 + isopentenyldehydrorhodopin"}
{"X":38816,"RHEA_ID":46970,"compounds":"AH2 + isopentenyldehydrorhodopin => A + dihydroisopentenyldehydrorhodopin"}
{"X":38817,"RHEA_ID":46971,"DIRECTION":"BI","MASTER_ID":46968,"metacyc":"RXN-16703","compounds":"A + dihydroisopentenyldehydrorhodopin <=> AH2 + isopentenyldehydrorhodopin"}
{"X":38818,"RHEA_ID":37068,"DIRECTION":"LR","MASTER_ID":37067,"ecocyc":"RXN0-5063","metacyc":"RXN0-5063","compounds":"[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine => 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine"}
{"X":38819,"RHEA_ID":46973,"compounds":"A + dihydrobisanhydrobacterioruberin => AH2 + bisanhydrobacterioruberin"}
{"X":38820,"RHEA_ID":46974,"compounds":"AH2 + bisanhydrobacterioruberin => A + dihydrobisanhydrobacterioruberin"}
{"X":38821,"RHEA_ID":37071,"compounds":"[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine = 2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine"}
{"X":38822,"RHEA_ID":37072,"compounds":"[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine => 2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine"}
{"X":38823,"RHEA_ID":46977,"DIRECTION":"LR","MASTER_ID":46976,"metacyc":"RXN-16526","compounds":"(S)-6-hydroxynicotine + O2 => 6-hydroxy-N-methylmyosmine + H2O2"}
{"X":38824,"RHEA_ID":46978,"compounds":"6-hydroxy-N-methylmyosmine + H2O2 => (S)-6-hydroxynicotine + O2"}
{"X":38825,"RHEA_ID":37075,"DIRECTION":"UN","MASTER_ID":37075,"ec":"2.8.4.5","compounds":"[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine"}
{"X":38826,"RHEA_ID":37076,"compounds":"[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine => 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine"}
{"X":38827,"RHEA_ID":46989,"DIRECTION":"LR","MASTER_ID":46988,"metacyc":"RXN-16528","compounds":"(R)-6-hydroxynicotine + O2 => 6-hydroxy-N-methylmyosmine + H2O2"}
{"X":38828,"RHEA_ID":46990,"compounds":"6-hydroxy-N-methylmyosmine + H2O2 => (R)-6-hydroxynicotine + O2"}
{"X":38829,"RHEA_ID":57010,"compounds":"2,2',3-trihydroxy-3'-methoxy-5,5'-dicarboxybiphenyl + formaldehyde + H2O + NAD(+) => 5,5'-dehydrodivanillate + H(+) + NADH + O2"}
{"X":38830,"RHEA_ID":37080,"compounds":"2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine => 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":38831,"RHEA_ID":46997,"DIRECTION":"LR","MASTER_ID":46996,"metacyc":"RXN-16527","compounds":"6-hydroxy-N-methylmyosmine + H2O => 6-hydroxypseudooxynicotine"}
{"X":38832,"RHEA_ID":46998,"compounds":"6-hydroxypseudooxynicotine => 6-hydroxy-N-methylmyosmine + H2O"}
{"X":38833,"RHEA_ID":57014,"compounds":"a menaquinol + sulfate => a menaquinone + H2O + sulfite"}
{"X":38834,"RHEA_ID":37084,"compounds":"[sulfur carrier]-SH + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + S-adenosyl-L-methionine => [sulfur carrier]-H + H(+) + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-homocysteine"}
{"X":38835,"RHEA_ID":37085,"compounds":"[sulfur carrier]-H + H(+) + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-homocysteine => [sulfur carrier]-SH + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + S-adenosyl-L-methionine"}
{"X":38836,"RHEA_ID":47002,"compounds":"NAD(+) + 2 NADPH + 2 oxidized [2Fe-2S]-[ferredoxin] => H(+) + NADH + 2 NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":38837,"RHEA_ID":37087,"DIRECTION":"UN","MASTER_ID":37087,"ec":"2.8.4.4","compounds":"[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine = 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine"}
{"X":38838,"RHEA_ID":37088,"DIRECTION":"LR","MASTER_ID":37087,"ecocyc":"RXN0-6366","metacyc":"RXN0-6366","compounds":"[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine => 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine"}
{"X":38839,"RHEA_ID":47005,"DIRECTION":"LR","MASTER_ID":47004,"ecocyc":"3.1.3.16-RXN","metacyc":"3.1.3.16-RXN","compounds":"H2O + O-phospho-L-threonyl-[protein] => L-threonyl-[protein] + phosphate"}
{"X":38840,"RHEA_ID":47006,"compounds":"L-threonyl-[protein] + phosphate => H2O + O-phospho-L-threonyl-[protein]"}
{"X":38841,"RHEA_ID":37092,"compounds":"(8Z,11Z,14Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(10Z,13Z,16Z)-docosatrienoyl-CoA + CO2 + CoA"}
{"X":38842,"RHEA_ID":47009,"compounds":"[DsrC protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide => [DsrC protein]-dithiol + 2 AH2 + H(+) + sulfite"}
{"X":38843,"RHEA_ID":37094,"compounds":"(8Z,11Z,14Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(10Z,13Z,16Z)-docosatrienoyl-CoA + CO2 + CoA"}
{"X":38844,"RHEA_ID":37095,"compounds":"(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(12Z,15Z,18Z,21Z)-tetracosatetraenoyl-CoA + CO2 + CoA"}
{"X":38845,"RHEA_ID":37096,"compounds":"(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(12Z,15Z,18Z,21Z)-tetracosatetraenoyl-CoA + CO2 + CoA"}
{"X":38846,"RHEA_ID":47013,"DIRECTION":"LR","MASTER_ID":47012,"metacyc":"RXN-11923","compounds":"[DsrC protein]-disulfide + H(+) + hydrogen sulfide => [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine"}
{"X":38847,"RHEA_ID":37098,"compounds":"(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(12Z,15Z,18Z,21Z)-tetracosatetraenoyl-CoA + CO2 + CoA"}
{"X":38848,"RHEA_ID":47015,"compounds":"[DsrC protein]-disulfide + H(+) + hydrogen sulfide <=> [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine"}
{"X":38849,"RHEA_ID":37100,"compounds":"a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + H2O => 7-methyl-GMP + a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+)"}
{"X":38850,"RHEA_ID":47017,"compounds":"[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 2 A + 3 H2O => [DsrC protein]-dithiol + 2 AH2 + 2 H(+) + sulfite"}
{"X":38851,"RHEA_ID":37103,"DIRECTION":"UN","MASTER_ID":37103,"ec":"3.6.1.59","compounds":"a 5'-(N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine) in mRNA + H2O = (N(2),N(2),N(7))-trimethylguanosine 5'-phosphate + a 5'-diphospho end in mRNA + 2 H(+)"}
{"X":38852,"RHEA_ID":37104,"compounds":"a 5'-(N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine) in mRNA + H2O => (N(2),N(2),N(7))-trimethylguanosine 5'-phosphate + a 5'-diphospho end in mRNA + 2 H(+)"}
{"X":38853,"RHEA_ID":47021,"compounds":"[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O => [DsrC protein]-disulfide + 3 AH2 + 2 H(+) + sulfite"}
{"X":38854,"RHEA_ID":37106,"compounds":"a 5'-(N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine) in mRNA + H2O <=> (N(2),N(2),N(7))-trimethylguanosine 5'-phosphate + a 5'-diphospho end in mRNA + 2 H(+)"}
{"X":38855,"RHEA_ID":47023,"DIRECTION":"BI","MASTER_ID":47020,"metacyc":"RXN-11944","compounds":"[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O <=> [DsrC protein]-disulfide + 3 AH2 + 2 H(+) + sulfite"}
{"X":38856,"RHEA_ID":37108,"DIRECTION":"LR","MASTER_ID":37107,"metacyc":"RXN-14704","reactome":"R-HSA-5694126.1","compounds":"7-methyl-GMP + H2O => N(7)-methylguanosine + phosphate"}
{"X":38857,"RHEA_ID":47025,"DIRECTION":"LR","MASTER_ID":47024,"metacyc":"RXN-16445","compounds":"[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O => [DsrC protein]-S-sulfo-L-cysteine/L-cysteine + 3 AH2 + H(+)"}
{"X":38858,"RHEA_ID":47026,"compounds":"[DsrC protein]-S-sulfo-L-cysteine/L-cysteine + 3 AH2 + H(+) => [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O"}
{"X":38859,"RHEA_ID":47027,"compounds":"[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O <=> [DsrC protein]-S-sulfo-L-cysteine/L-cysteine + 3 AH2 + H(+)"}
{"X":38860,"RHEA_ID":37112,"compounds":"(15Z)-tetracosenoyl-CoA + sphing-4-enine => CoA + H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine"}
{"X":38861,"RHEA_ID":47029,"DIRECTION":"LR","MASTER_ID":47028,"metacyc":"RXN-16446","compounds":"[DsrC protein]-S-sulfo-L-cysteine/L-cysteine => [DsrC protein]-disulfide + H(+) + sulfite"}
{"X":38862,"RHEA_ID":37114,"compounds":"(15Z)-tetracosenoyl-CoA + sphing-4-enine <=> CoA + H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine"}
{"X":38863,"RHEA_ID":37115,"compounds":"sphing-4-enine + tetracosanoyl-CoA = CoA + H(+) + N-(tetracosanoyl)-sphing-4-enine"}
{"X":38864,"RHEA_ID":37116,"compounds":"sphing-4-enine + tetracosanoyl-CoA => CoA + H(+) + N-(tetracosanoyl)-sphing-4-enine"}
{"X":38865,"RHEA_ID":37117,"compounds":"CoA + H(+) + N-(tetracosanoyl)-sphing-4-enine => sphing-4-enine + tetracosanoyl-CoA"}
{"X":38866,"RHEA_ID":37118,"compounds":"sphing-4-enine + tetracosanoyl-CoA <=> CoA + H(+) + N-(tetracosanoyl)-sphing-4-enine"}
{"X":38867,"RHEA_ID":47035,"DIRECTION":"BI","MASTER_ID":47032,"metacyc":"RXN-16820","compounds":"AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA <=> 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]"}
{"X":38868,"RHEA_ID":37120,"DIRECTION":"LR","MASTER_ID":37119,"metacyc":"RXN-14520","compounds":"7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + CO2 + S-adenosyl-L-methionine => 2 H(+) + S-adenosyl-L-homocysteine + wybutosine(37) in tRNA(Phe)"}
{"X":38869,"RHEA_ID":47037,"compounds":"uridine in 5S rRNA => pseudouridine in 5S rRNA"}
{"X":38870,"RHEA_ID":47038,"compounds":"pseudouridine in 5S rRNA => uridine in 5S rRNA"}
{"X":38871,"RHEA_ID":47039,"compounds":"uridine in 5S rRNA <=> pseudouridine in 5S rRNA"}
{"X":38872,"RHEA_ID":37124,"compounds":"sphing-4-enine + tetracosenoyl-CoA => CoA + H(+) + N-(tetracosenoyl)-sphing-4-enine"}
{"X":38873,"RHEA_ID":37125,"compounds":"CoA + H(+) + N-(tetracosenoyl)-sphing-4-enine => sphing-4-enine + tetracosenoyl-CoA"}
{"X":38874,"RHEA_ID":37126,"compounds":"sphing-4-enine + tetracosenoyl-CoA <=> CoA + H(+) + N-(tetracosenoyl)-sphing-4-enine"}
{"X":38875,"RHEA_ID":50417,"DIRECTION":"LR","MASTER_ID":50416,"ecocyc":"RXN-17846","metacyc":"RXN-17846","compounds":"L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] => H(+) + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu)"}
{"X":38876,"RHEA_ID":37128,"compounds":"2-oxoglutarate + dioxidophosphate + H2O2 => CO2 + H(+) + phosphonate + succinate"}
{"X":38877,"RHEA_ID":47045,"compounds":"3-dehydrocarnitine + acetyl-CoA => acetoacetate + N,N,N-trimethylglycyl-CoA"}
{"X":38878,"RHEA_ID":37130,"compounds":"2-oxoglutarate + dioxidophosphate + H2O2 <=> CO2 + H(+) + phosphonate + succinate"}
{"X":38879,"RHEA_ID":37131,"compounds":"(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":38880,"RHEA_ID":37132,"compounds":"(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":38881,"RHEA_ID":47049,"DIRECTION":"LR","MASTER_ID":47048,"metacyc":"SHIKIMATE-PQQ-RXN","compounds":"a quinone + shikimate => 3-dehydroshikimate + a quinol"}
{"X":38882,"RHEA_ID":37134,"compounds":"(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":38883,"RHEA_ID":37135,"compounds":"(9Z)-octadecenoyl-CoA + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate = 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}
{"X":38884,"RHEA_ID":37136,"compounds":"(9Z)-octadecenoyl-CoA + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate => 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}
{"X":38885,"RHEA_ID":47053,"DIRECTION":"LR","MASTER_ID":47052,"metacyc":"RXN-8587","compounds":"(2E,6E)-farnesyl diphosphate => alpha-selinene + diphosphate"}
{"X":38886,"RHEA_ID":37138,"compounds":"(9Z)-octadecenoyl-CoA + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate <=> 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}
{"X":38887,"RHEA_ID":57070,"compounds":"3-oxo-isoapionate 4-phosphate + ADP + H(+) => 3-oxo-isoapionate + ATP"}
{"X":38888,"RHEA_ID":37140,"compounds":"(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycero-3-phosphate => 1-(9Z,12Z,15Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}
{"X":38889,"RHEA_ID":47057,"compounds":"4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}
{"X":38890,"RHEA_ID":37142,"compounds":"(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycero-3-phosphate <=> 1-(9Z,12Z,15Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}
{"X":38891,"RHEA_ID":50433,"compounds":"AH2 + prostaglandin G1 => A + H2O + prostaglandin H1"}
{"X":38892,"RHEA_ID":37144,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA => 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":38893,"RHEA_ID":37145,"compounds":"1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA"}
{"X":38894,"RHEA_ID":37146,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":38895,"RHEA_ID":47063,"compounds":"4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":38896,"RHEA_ID":37148,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA => 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":38897,"RHEA_ID":37149,"compounds":"1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA"}
{"X":38898,"RHEA_ID":37150,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA <=> 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":38899,"RHEA_ID":47067,"compounds":"4alpha-hydroxymethyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 4alpha-formyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":38900,"RHEA_ID":37152,"compounds":"(9Z)-octadecenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate => 1-heptadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}
{"X":38901,"RHEA_ID":47069,"compounds":"4alpha-formyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 => 4alpha-carboxyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":38902,"RHEA_ID":37154,"compounds":"(9Z)-octadecenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate <=> 1-heptadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}
{"X":38903,"RHEA_ID":47071,"compounds":"4alpha-formyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 <=> 4alpha-carboxyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":38904,"RHEA_ID":37156,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + heptadecanoyl-CoA => 1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":38905,"RHEA_ID":47073,"compounds":"1-eicosanoylglycerol + H2O => eicosanoate + glycerol + H(+)"}
{"X":38906,"RHEA_ID":37158,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + heptadecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":38907,"RHEA_ID":47075,"compounds":"1-eicosanoylglycerol + H2O <=> eicosanoate + glycerol + H(+)"}
{"X":38908,"RHEA_ID":37160,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA"}
{"X":38909,"RHEA_ID":47077,"compounds":"17beta-hydroxyandrosta-1,4-dien-3-one + H(+) + NADPH => 17beta-hydroxy-5beta-androst-1-en-3-one + NADP(+)"}
{"X":38910,"RHEA_ID":37162,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA"}
{"X":38911,"RHEA_ID":37163,"compounds":"(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":38912,"RHEA_ID":37164,"compounds":"(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":38913,"RHEA_ID":47081,"compounds":"17beta-hydroxyestr-4-en-3-one + H(+) + NADPH => 17beta-hydroxy-5beta-estran-3-one + NADP(+)"}
{"X":38914,"RHEA_ID":47082,"compounds":"17beta-hydroxy-5beta-estran-3-one + NADP(+) => 17beta-hydroxyestr-4-en-3-one + H(+) + NADPH"}
{"X":38915,"RHEA_ID":37167,"DIRECTION":"UN","MASTER_ID":37167,"ec":"1.1.1.354","compounds":"(2E,6E)-farnesol + NAD(+) = (2E,6E)-farnesal + H(+) + NADH"}
{"X":38916,"RHEA_ID":37168,"compounds":"(2E,6E)-farnesol + NAD(+) => (2E,6E)-farnesal + H(+) + NADH"}
{"X":38917,"RHEA_ID":47085,"compounds":"4-methylsulfanyl-2-oxobutanoate + L-tyrosine => 3-(4-hydroxyphenyl)pyruvate + L-methionine"}
{"X":38918,"RHEA_ID":57101,"DIRECTION":"LR","MASTER_ID":57100,"metacyc":"RXN-14006","compounds":"5-methylsulfanyl-D-ribulose 1-phosphate => 1-methylsulfanyl-D-xylulose 5-phosphate"}
{"X":38919,"RHEA_ID":37171,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":38920,"RHEA_ID":37172,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA => 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":38921,"RHEA_ID":47089,"DIRECTION":"LR","MASTER_ID":47088,"reactome":"R-HSA-193455.1","compounds":"(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + NAD(+) => 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH"}
{"X":38922,"RHEA_ID":47090,"compounds":"3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH => (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + NAD(+)"}
{"X":38923,"RHEA_ID":37175,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + pentadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-pentadecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":38924,"RHEA_ID":37176,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + pentadecanoyl-CoA => 1-(9Z)-octadecenoyl-2-pentadecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":38925,"RHEA_ID":37177,"compounds":"1-(9Z)-octadecenoyl-2-pentadecanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + pentadecanoyl-CoA"}
{"X":38926,"RHEA_ID":47094,"compounds":"dipicolinate + H(+) + NADPH => (S)-2,3-dihydrodipicolinate + NADP(+)"}
{"X":38927,"RHEA_ID":50469,"DIRECTION":"LR","MASTER_ID":50468,"metacyc":"RXN-17236","compounds":"4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 27 H(+) + 9 malonyl-CoA + 18 NADPH => 19-(4-hydroxyphenyl)nonadecanoyl-[4-hydroxyphenylalkanoate synthase] + 9 CO2 + 9 CoA + 9 H2O + 18 NADP(+)"}
{"X":38928,"RHEA_ID":37180,"compounds":"(9Z)-octadecenoyl-CoA + 1-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphate => (6Z,9Z,12Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}
{"X":38929,"RHEA_ID":37181,"compounds":"(6Z,9Z,12Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphate"}
{"X":38930,"RHEA_ID":47098,"compounds":"(2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate + 7 diphosphate => (2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate"}
{"X":38931,"RHEA_ID":37183,"compounds":"(9Z)-octadecenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphate = 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}
{"X":38932,"RHEA_ID":37184,"compounds":"(9Z)-octadecenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphate => 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}
{"X":38933,"RHEA_ID":47101,"DIRECTION":"LR","MASTER_ID":47100,"reactome":"R-HSA-192312.1","compounds":"choloyl-CoA + taurine => CoA + H(+) + taurocholate"}
{"X":38934,"RHEA_ID":37186,"compounds":"(9Z)-octadecenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphate <=> 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}
{"X":38935,"RHEA_ID":37187,"compounds":"(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycerol 3-phosphate = 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}
{"X":38936,"RHEA_ID":37188,"compounds":"(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycerol 3-phosphate => 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}
{"X":38937,"RHEA_ID":37189,"compounds":"1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycerol 3-phosphate"}
{"X":38938,"RHEA_ID":47106,"compounds":"5,6,7,8-tetrahydromethanopterin + L-serine => 5,10-methylenetetrahydromethanopterin + glycine + H2O"}
{"X":38939,"RHEA_ID":37191,"DIRECTION":"UN","MASTER_ID":37191,"ec":"3.1.4.37","compounds":"2',3'-cyclic AMP + H2O = adenosine 2'-phosphate + H(+)"}
{"X":38940,"RHEA_ID":37192,"compounds":"2',3'-cyclic AMP + H2O => adenosine 2'-phosphate + H(+)"}
{"X":38941,"RHEA_ID":37193,"compounds":"adenosine 2'-phosphate + H(+) => 2',3'-cyclic AMP + H2O"}
{"X":38942,"RHEA_ID":47110,"compounds":"H2O + taurocholate => cholate + taurine"}
{"X":38943,"RHEA_ID":37195,"compounds":"octadecanoyl-CoA + sn-glycerol 3-phosphate = 1-octadecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":38944,"RHEA_ID":37196,"compounds":"octadecanoyl-CoA + sn-glycerol 3-phosphate => 1-octadecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":38945,"RHEA_ID":37197,"compounds":"1-octadecanoyl-sn-glycero-3-phosphate + CoA => octadecanoyl-CoA + sn-glycerol 3-phosphate"}
{"X":38946,"RHEA_ID":57128,"compounds":"H2O + 2 oxidized [azurin] + tyramine = (4-hydroxyphenyl)acetaldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin]"}
{"X":38947,"RHEA_ID":50489,"DIRECTION":"LR","MASTER_ID":50488,"metacyc":"RXN-17853","compounds":"acetyl-CoA + N-terminal L-methionyl-L-glutamyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein]"}
{"X":38948,"RHEA_ID":37200,"compounds":"(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphate => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":38949,"RHEA_ID":37201,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphate"}
{"X":38950,"RHEA_ID":57132,"compounds":"L-ascorbate + O2 + tyramine = (2R)-1-(4-hydroxyphenyl)-2-aminoethanol + H2O + L-dehydroascorbate"}
{"X":38951,"RHEA_ID":37203,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphate = 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA"}
{"X":38952,"RHEA_ID":37204,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphate => 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA"}
{"X":38953,"RHEA_ID":37205,"compounds":"1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA => (9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphate"}
{"X":38954,"RHEA_ID":47122,"compounds":"H2O + N-docosanoylglycine => docosanoate + glycine"}
{"X":38955,"RHEA_ID":50497,"DIRECTION":"LR","MASTER_ID":50496,"metacyc":"RXN-17862","compounds":"acetyl-CoA + N-terminal glycyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetylglycyl-[protein]"}
{"X":38956,"RHEA_ID":37208,"compounds":"(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":38957,"RHEA_ID":37209,"compounds":"1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA => (9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":38958,"RHEA_ID":47126,"compounds":"H2O + N-hexacosanoylglycine => glycine + hexacosanoate"}
{"X":38959,"RHEA_ID":37211,"DIRECTION":"UN","MASTER_ID":37211,"ec":"3.1.4.37","compounds":"2',3'-cyclic GMP + H2O = guanosine 2'-monophosphate + H(+)"}
{"X":38960,"RHEA_ID":37212,"DIRECTION":"LR","MASTER_ID":37211,"metacyc":"RXN-12058","compounds":"2',3'-cyclic GMP + H2O => guanosine 2'-monophosphate + H(+)"}
{"X":38961,"RHEA_ID":37213,"compounds":"guanosine 2'-monophosphate + H(+) => 2',3'-cyclic GMP + H2O"}
{"X":38962,"RHEA_ID":57144,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)"}
{"X":38963,"RHEA_ID":50505,"DIRECTION":"LR","MASTER_ID":50504,"metacyc":"RXN-17863","compounds":"acetyl-CoA + N-terminal L-seryl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[protein]"}
{"X":38964,"RHEA_ID":37220,"compounds":"A + D-valine + H2O => 3-methyl-2-oxobutanoate + AH2 + NH4(+)"}
{"X":38965,"RHEA_ID":37221,"compounds":"3-methyl-2-oxobutanoate + AH2 + NH4(+) => A + D-valine + H2O"}
{"X":38966,"RHEA_ID":47134,"compounds":"11-cis-retinoate + 2 H(+) + NADH => 11-cis-retinal + H2O + NAD(+)"}
{"X":38967,"RHEA_ID":37223,"compounds":"(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphate + CoA"}
{"X":38968,"RHEA_ID":37224,"compounds":"(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate => 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphate + CoA"}
{"X":38969,"RHEA_ID":37225,"compounds":"1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphate + CoA => (9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate"}
{"X":38970,"RHEA_ID":47138,"compounds":"AMP + diphosphate + lithocholoyl-CoA => ATP + CoA + lithocholate"}
{"X":38971,"RHEA_ID":60671,"compounds":"(R,R)-chrysanthemol + NAD(+) <=> (1R,3R)-chrysanthemal + H(+) + NADH"}
{"X":38972,"RHEA_ID":37228,"compounds":"(E,E)-sorbate + H(+) => (E)-1,3-pentadiene + CO2"}
{"X":38973,"RHEA_ID":37229,"compounds":"(E)-1,3-pentadiene + CO2 => (E,E)-sorbate + H(+)"}
{"X":38974,"RHEA_ID":57156,"compounds":"2-oxoglutarate + L-lysyl-[protein] + O2 = 4-hydroxy-L-lysyl-[protein] + CO2 + succinate"}
{"X":38975,"RHEA_ID":37231,"compounds":"H2O + L-alaninamide = L-alanine + NH4(+)"}
{"X":38976,"RHEA_ID":37232,"compounds":"H2O + L-alaninamide => L-alanine + NH4(+)"}
{"X":38977,"RHEA_ID":37233,"compounds":"L-alanine + NH4(+) => H2O + L-alaninamide"}
{"X":38978,"RHEA_ID":47146,"compounds":"(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => (9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}
{"X":38979,"RHEA_ID":37239,"DIRECTION":"UN","MASTER_ID":37239,"ec":"3.1.4.37","compounds":"2',3'-cyclic UMP + H2O = H(+) + uridine 2'-phosphate"}
{"X":38980,"RHEA_ID":37240,"DIRECTION":"LR","MASTER_ID":37239,"metacyc":"RXN-12060","compounds":"2',3'-cyclic UMP + H2O => H(+) + uridine 2'-phosphate"}
{"X":38981,"RHEA_ID":37241,"compounds":"H(+) + uridine 2'-phosphate => 2',3'-cyclic UMP + H2O"}
{"X":38982,"RHEA_ID":57164,"compounds":"2-oxoglutarate + L-arginyl-[RCC1 domain-containing protein] + O2 = (3R)-3-hydroxy-L-arginyl-[RCC1 domain-containing protein] + CO2 + succinate"}
{"X":38983,"RHEA_ID":60683,"compounds":"(+)-artemisinic aldehyde + H2O + NADP(+) <=> (+)-artemisinate + 2 H(+) + NADPH"}
{"X":38984,"RHEA_ID":37244,"compounds":"(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + CO2 + CoA"}
{"X":38985,"RHEA_ID":37245,"compounds":"3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + CO2 + CoA => (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + H(+) + malonyl-CoA"}
{"X":38986,"RHEA_ID":57168,"compounds":"(R)-2-hydroxyglutarate + FAD + H(+) = 2-oxoglutarate + FADH2"}
{"X":38987,"RHEA_ID":60687,"compounds":"(11R)-dihydroartemisinic aldehyde + H2O + NADP(+) <=> (11R)-dihydroartemisinate + 2 H(+) + NADPH"}
{"X":38988,"RHEA_ID":37248,"compounds":"H2O + thymidine 3'-monophosphate => phosphate + thymidine"}
{"X":38989,"RHEA_ID":37249,"compounds":"phosphate + thymidine => H2O + thymidine 3'-monophosphate"}
{"X":38990,"RHEA_ID":57172,"compounds":"(S)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH"}
{"X":38991,"RHEA_ID":50531,"compounds":"acetyl-CoA + N-terminal L-methionyl-L-phenylalanyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein]"}
{"X":38992,"RHEA_ID":37252,"compounds":"cysteamine S-phosphate + H2O => cysteamine + phosphate"}
{"X":38993,"RHEA_ID":37253,"compounds":"cysteamine + phosphate => cysteamine S-phosphate + H2O"}
{"X":38994,"RHEA_ID":47162,"compounds":"4-methyl-5alpha-cholesta-8,24-dien-3-one + CO2 + NADH => 4alpha-carboxyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+)"}
{"X":38995,"RHEA_ID":60695,"compounds":"(E)-non-2-enal + H2O + NADP(+) <=> (E)-non-2-enoate + 2 H(+) + NADPH"}
{"X":38996,"RHEA_ID":37256,"compounds":"A + D-asparagine + H2O => 2-oxosuccinamate + AH2 + NH4(+)"}
{"X":38997,"RHEA_ID":37257,"compounds":"2-oxosuccinamate + AH2 + NH4(+) => A + D-asparagine + H2O"}
{"X":38998,"RHEA_ID":47166,"compounds":"CO2 + NADH + zymosterone => 4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+)"}
{"X":38999,"RHEA_ID":50538,"compounds":"H2O + prostaglandin A2 => prostaglandin E2"}
{"X":39000,"RHEA_ID":37260,"compounds":"(2S)-2-aminobutanoate + H2O + NAD(+) => 2-oxobutanoate + H(+) + NADH + NH4(+)"}
{"X":39001,"RHEA_ID":37261,"compounds":"2-oxobutanoate + H(+) + NADH + NH4(+) => (2S)-2-aminobutanoate + H2O + NAD(+)"}
{"X":39002,"RHEA_ID":37262,"compounds":"(2S)-2-aminobutanoate + H2O + NAD(+) <=> 2-oxobutanoate + H(+) + NADH + NH4(+)"}
{"X":39003,"RHEA_ID":37263,"compounds":"ATP + H2O + L-alanyl-L-aspartate(out) = ADP + H(+) + L-alanyl-L-aspartate(in) + phosphate"}
{"X":39004,"RHEA_ID":37264,"compounds":"ATP + H2O + L-alanyl-L-aspartate(out) => ADP + H(+) + L-alanyl-L-aspartate(in) + phosphate"}
{"X":39005,"RHEA_ID":37265,"compounds":"ADP + H(+) + L-alanyl-L-aspartate(in) + phosphate => ATP + H2O + L-alanyl-L-aspartate(out)"}
{"X":39006,"RHEA_ID":57188,"DIRECTION":"UN","MASTER_ID":57188,"ec":"3.5.1.124","compounds":"H2O + N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein] = glycolate + H(+) + L-arginyl-[protein]"}
{"X":39007,"RHEA_ID":37267,"compounds":"H2O + L-alanyl-L-aspartate = L-alanine + L-aspartate"}
{"X":39008,"RHEA_ID":37268,"DIRECTION":"LR","MASTER_ID":37267,"metacyc":"RXN0-6975","compounds":"H2O + L-alanyl-L-aspartate => L-alanine + L-aspartate"}
{"X":39009,"RHEA_ID":37269,"compounds":"L-alanine + L-aspartate => H2O + L-alanyl-L-aspartate"}
{"X":39010,"RHEA_ID":57192,"DIRECTION":"UN","MASTER_ID":57192,"ec":"3.5.1.124","compounds":"H2O + N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein] = glycolate + H(+) + L-lysyl-[protein]"}
{"X":39011,"RHEA_ID":60711,"compounds":"(1R,3R)-chrysanthemal + H2O + NAD(+) <=> (1R,3R)-chrysanthemate + 2 H(+) + NADH"}
{"X":39012,"RHEA_ID":37272,"DIRECTION":"LR","MASTER_ID":37271,"metacyc":"3.6.3.23-RXN","compounds":"ATP + H2O + L-alanyl-L-glutamine(out) => ADP + H(+) + L-alanyl-L-glutamine(in) + phosphate"}
{"X":39013,"RHEA_ID":37273,"compounds":"ADP + H(+) + L-alanyl-L-glutamine(in) + phosphate => ATP + H2O + L-alanyl-L-glutamine(out)"}
{"X":39014,"RHEA_ID":37274,"compounds":"ATP + H2O + L-alanyl-L-glutamine(out) <=> ADP + H(+) + L-alanyl-L-glutamine(in) + phosphate"}
{"X":39015,"RHEA_ID":50554,"compounds":"prostaglandin B1 => prostaglandin C1"}
{"X":39016,"RHEA_ID":37276,"DIRECTION":"LR","MASTER_ID":37275,"metacyc":"RXN0-6976","compounds":"H2O + L-alanyl-L-glutamine => L-alanine + L-glutamine"}
{"X":39017,"RHEA_ID":37277,"compounds":"L-alanine + L-glutamine => H2O + L-alanyl-L-glutamine"}
{"X":39018,"RHEA_ID":47186,"compounds":"2 [Fe(III)-cytochrome b5] + cholesta-5,7,24-trien-3beta-ol + 2 H2O => 5alpha-cholesta-7,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}
{"X":39019,"RHEA_ID":60719,"compounds":"(1R,3R)-chrysanthemal + H2O + NADP(+) <=> (1R,3R)-chrysanthemate + 2 H(+) + NADPH"}
{"X":39020,"RHEA_ID":37280,"compounds":"ATP + H2O + L-alanyl-L-histidine(out) => ADP + H(+) + L-alanyl-L-histidine(in) + phosphate"}
{"X":39021,"RHEA_ID":37281,"compounds":"ADP + H(+) + L-alanyl-L-histidine(in) + phosphate => ATP + H2O + L-alanyl-L-histidine(out)"}
{"X":39022,"RHEA_ID":47190,"compounds":"[methyl-Co(III) methylated-thiol-specific corrinoid protein] + hydrogen sulfide => [Co(I) methylated-thiol-specific corrinoid protein] + methanethiol"}
{"X":39023,"RHEA_ID":37283,"compounds":"H2O + L-alanyl-L-histidine = L-alanine + L-histidine"}
{"X":39024,"RHEA_ID":37284,"DIRECTION":"LR","MASTER_ID":37283,"metacyc":"RXN0-6978","compounds":"H2O + L-alanyl-L-histidine => L-alanine + L-histidine"}
{"X":39025,"RHEA_ID":37285,"compounds":"L-alanine + L-histidine => H2O + L-alanyl-L-histidine"}
{"X":39026,"RHEA_ID":57208,"compounds":"glyoxal + L-cysteinyl-[protein] = S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein]"}
{"X":39027,"RHEA_ID":37287,"compounds":"ATP + H2O + L-alanyl-L-leucine(out) = ADP + H(+) + L-alanyl-L-leucine(in) + phosphate"}
{"X":39028,"RHEA_ID":37288,"compounds":"ATP + H2O + L-alanyl-L-leucine(out) => ADP + H(+) + L-alanyl-L-leucine(in) + phosphate"}
{"X":39029,"RHEA_ID":37289,"compounds":"ADP + H(+) + L-alanyl-L-leucine(in) + phosphate => ATP + H2O + L-alanyl-L-leucine(out)"}
{"X":39030,"RHEA_ID":47198,"compounds":"a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein] => a short-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":39031,"RHEA_ID":37291,"compounds":"H2O + L-alanyl-L-leucine = L-alanine + L-leucine"}
{"X":39032,"RHEA_ID":37292,"DIRECTION":"LR","MASTER_ID":37291,"metacyc":"RXN0-6979","compounds":"H2O + L-alanyl-L-leucine => L-alanine + L-leucine"}
{"X":39033,"RHEA_ID":37293,"compounds":"L-alanine + L-leucine => H2O + L-alanyl-L-leucine"}
{"X":39034,"RHEA_ID":47202,"compounds":"(24S)-7alpha,24-dihydroxycholest-4-en-3-one + H(+) + NADH => (24S)-7alpha-dihydroxycholesterol + NAD(+)"}
{"X":39035,"RHEA_ID":37295,"compounds":"ATP + H2O + L-alanyl-L-threonine(out) = ADP + H(+) + L-alanyl-L-threonine(in) + phosphate"}
{"X":39036,"RHEA_ID":37296,"compounds":"ATP + H2O + L-alanyl-L-threonine(out) => ADP + H(+) + L-alanyl-L-threonine(in) + phosphate"}
{"X":39037,"RHEA_ID":37297,"compounds":"ADP + H(+) + L-alanyl-L-threonine(in) + phosphate => ATP + H2O + L-alanyl-L-threonine(out)"}
{"X":39038,"RHEA_ID":47206,"compounds":"16alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => estrone + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":39039,"RHEA_ID":37299,"compounds":"H2O + L-alanyl-L-threonine = L-alanine + L-threonine"}
{"X":39040,"RHEA_ID":37300,"DIRECTION":"LR","MASTER_ID":37299,"metacyc":"RXN0-6980","compounds":"H2O + L-alanyl-L-threonine => L-alanine + L-threonine"}
{"X":39041,"RHEA_ID":47209,"compounds":"estrone + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":39042,"RHEA_ID":37302,"compounds":"H2O + L-alanyl-L-threonine <=> L-alanine + L-threonine"}
{"X":39043,"RHEA_ID":37303,"compounds":"ATP + glycyl-L-asparagine(out) + H2O = ADP + glycyl-L-asparagine(in) + H(+) + phosphate"}
{"X":39044,"RHEA_ID":37304,"compounds":"ATP + glycyl-L-asparagine(out) + H2O => ADP + glycyl-L-asparagine(in) + H(+) + phosphate"}
{"X":39045,"RHEA_ID":37305,"compounds":"ADP + glycyl-L-asparagine(in) + H(+) + phosphate => ATP + glycyl-L-asparagine(out) + H2O"}
{"X":39046,"RHEA_ID":37306,"compounds":"ATP + glycyl-L-asparagine(out) + H2O <=> ADP + glycyl-L-asparagine(in) + H(+) + phosphate"}
{"X":39047,"RHEA_ID":47215,"compounds":"17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":39048,"RHEA_ID":37308,"DIRECTION":"LR","MASTER_ID":37307,"metacyc":"RXN0-6982","compounds":"glycyl-L-asparagine + H2O => glycine + L-asparagine"}
{"X":39049,"RHEA_ID":47217,"compounds":"17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxyestradiol-17beta + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":39050,"RHEA_ID":37310,"compounds":"glycyl-L-asparagine + H2O <=> glycine + L-asparagine"}
{"X":39051,"RHEA_ID":47219,"compounds":"17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxyestradiol-17beta + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":39052,"RHEA_ID":37312,"compounds":"ATP + glycyl-L-glutamine(out) + H2O => ADP + glycyl-L-glutamine(in) + H(+) + phosphate"}
{"X":39053,"RHEA_ID":47221,"compounds":"3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] => 3beta,16alpha-dihydroxy-androst-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":39054,"RHEA_ID":37314,"compounds":"ATP + glycyl-L-glutamine(out) + H2O <=> ADP + glycyl-L-glutamine(in) + H(+) + phosphate"}
{"X":39055,"RHEA_ID":47223,"compounds":"3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta,16alpha-dihydroxy-androst-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":39056,"RHEA_ID":37316,"DIRECTION":"LR","MASTER_ID":37315,"metacyc":"RXN0-6983","compounds":"glycyl-L-glutamine + H2O => glycine + L-glutamine"}
{"X":39057,"RHEA_ID":47225,"compounds":"3beta-sulfooxy-androst-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] => 3beta-sulfooxy-16alpha-hydroxy-androst-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":39058,"RHEA_ID":37318,"compounds":"glycyl-L-glutamine + H2O <=> glycine + L-glutamine"}
{"X":39059,"RHEA_ID":47227,"compounds":"3beta-sulfooxy-androst-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta-sulfooxy-16alpha-hydroxy-androst-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":39060,"RHEA_ID":37320,"compounds":"ATP + glycyl-L-methionine(out) + H2O => ADP + glycyl-L-methionine(in) + H(+) + phosphate"}
{"X":39061,"RHEA_ID":47229,"compounds":"docosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-docosenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":39062,"RHEA_ID":37322,"compounds":"ATP + glycyl-L-methionine(out) + H2O <=> ADP + glycyl-L-methionine(in) + H(+) + phosphate"}
{"X":39063,"RHEA_ID":47231,"compounds":"docosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-docosenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":39064,"RHEA_ID":37324,"DIRECTION":"LR","MASTER_ID":37323,"metacyc":"RXN0-6974","compounds":"glycyl-L-methionine + H2O => glycine + L-methionine"}
{"X":39065,"RHEA_ID":47233,"compounds":"H(+) + oxidized [electron-transfer flavoprotein] + tetracosanoyl-CoA => (2E)-tetracosenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":39066,"RHEA_ID":37326,"compounds":"glycyl-L-methionine + H2O <=> glycine + L-methionine"}
{"X":39067,"RHEA_ID":47235,"compounds":"H(+) + oxidized [electron-transfer flavoprotein] + tetracosanoyl-CoA <=> (2E)-tetracosenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":39068,"RHEA_ID":37328,"compounds":"ATP + H2O + L-methionyl-L-alanine(out) => ADP + H(+) + L-methionyl-L-alanine(in) + phosphate"}
{"X":39069,"RHEA_ID":47237,"compounds":"eicosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":39070,"RHEA_ID":37330,"compounds":"ATP + H2O + L-methionyl-L-alanine(out) <=> ADP + H(+) + L-methionyl-L-alanine(in) + phosphate"}
{"X":39071,"RHEA_ID":47239,"compounds":"eicosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":39072,"RHEA_ID":37332,"DIRECTION":"LR","MASTER_ID":37331,"metacyc":"RXN0-6985","compounds":"H2O + L-methionyl-L-alanine => L-alanine + L-methionine"}
{"X":39073,"RHEA_ID":47241,"compounds":"H(+) + octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] => (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":39074,"RHEA_ID":37334,"compounds":"H2O + L-methionyl-L-alanine <=> L-alanine + L-methionine"}
{"X":39075,"RHEA_ID":47243,"compounds":"H(+) + octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":39076,"RHEA_ID":37336,"DIRECTION":"LR","MASTER_ID":37335,"metacyc":"RXN-11211","reactome":"R-HSA-73618.2","compounds":"5,6-dihydrothymine + H2O => 3-(carbamoylamino)-2-methylpropanoate + H(+)"}
{"X":39077,"RHEA_ID":47245,"compounds":"(2R)-3-phosphoglycerate + an NDP-alpha-D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + a ribonucleoside 5'-diphosphate + H(+)"}
{"X":39078,"RHEA_ID":37338,"compounds":"5,6-dihydrothymine + H2O <=> 3-(carbamoylamino)-2-methylpropanoate + H(+)"}
{"X":39079,"RHEA_ID":57261,"compounds":"H2O + N(2)-(1-hydroxy-2-oxopropyl)-GDP => GDP + H(+) + lactate"}
{"X":39080,"RHEA_ID":37340,"DIRECTION":"LR","MASTER_ID":37339,"metacyc":"RXN-11210","reactome":"R-HSA-73620.3","compounds":"3-(carbamoylamino)-2-methylpropanoate + 2 H(+) + H2O => (R)-3-amino-2-methylpropanoate + CO2 + NH4(+)"}
{"X":39081,"RHEA_ID":37341,"compounds":"(R)-3-amino-2-methylpropanoate + CO2 + NH4(+) => 3-(carbamoylamino)-2-methylpropanoate + 2 H(+) + H2O"}
{"X":39082,"RHEA_ID":37342,"compounds":"3-(carbamoylamino)-2-methylpropanoate + 2 H(+) + H2O <=> (R)-3-amino-2-methylpropanoate + CO2 + NH4(+)"}
{"X":39083,"RHEA_ID":47251,"compounds":"2 [Fe(III)cytochrome c] + L-gulono-1,4-lactone <=> 2 [Fe(II)cytochrome c] + 3 H(+) + L-ascorbate"}
{"X":39084,"RHEA_ID":37344,"compounds":"adenosine 2'-phosphate + H2O => adenosine + phosphate"}
{"X":39085,"RHEA_ID":37345,"compounds":"adenosine + phosphate => adenosine 2'-phosphate + H2O"}
{"X":39086,"RHEA_ID":37346,"compounds":"adenosine 2'-phosphate + H2O <=> adenosine + phosphate"}
{"X":39087,"RHEA_ID":47255,"compounds":"O2 + progesterone + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":39088,"RHEA_ID":37348,"DIRECTION":"LR","MASTER_ID":37347,"metacyc":"RXN-11298","compounds":"(R)-lactate + ATP + D-alanine => ADP + D-alanyl-(R)-lactate + phosphate"}
{"X":39089,"RHEA_ID":47257,"compounds":"androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":39090,"RHEA_ID":47258,"compounds":"6beta-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":39091,"RHEA_ID":47259,"compounds":"androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":39092,"RHEA_ID":37352,"DIRECTION":"LR","MASTER_ID":37351,"ecocyc":"RXN-14511","metacyc":"RXN-14511","compounds":"cytidine 2'-phosphate + H2O => cytidine + phosphate"}
{"X":39093,"RHEA_ID":37353,"compounds":"cytidine + phosphate => cytidine 2'-phosphate + H2O"}
{"X":39094,"RHEA_ID":37354,"compounds":"cytidine 2'-phosphate + H2O <=> cytidine + phosphate"}
{"X":39095,"RHEA_ID":47263,"compounds":"O2 + progesterone + reduced [NADPH--hemoprotein reductase] <=> 16alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":39096,"RHEA_ID":37356,"compounds":"H2O + uridine 2'-phosphate => phosphate + uridine"}
{"X":39097,"RHEA_ID":47265,"DIRECTION":"LR","MASTER_ID":47264,"reactome":"R-HSA-389632.2","compounds":"2,6,10,14-tetramethylpentadecanoate + ATP + CoA => AMP + diphosphate + pristanoyl-CoA"}
{"X":39098,"RHEA_ID":37358,"compounds":"H2O + uridine 2'-phosphate <=> phosphate + uridine"}
{"X":39099,"RHEA_ID":47267,"compounds":"2,6,10,14-tetramethylpentadecanoate + ATP + CoA <=> AMP + diphosphate + pristanoyl-CoA"}
{"X":39100,"RHEA_ID":37360,"DIRECTION":"LR","MASTER_ID":37359,"ecocyc":"TRANS-RXN-167A","metacyc":"TRANS-RXN-167A","compounds":"D-glucosamine(out) + N(pros)-phospho-L-histidyl-[protein] => D-glucosamine 6-phosphate(in) + L-histidyl-[protein]"}
{"X":39101,"RHEA_ID":37361,"compounds":"D-glucosamine 6-phosphate(in) + L-histidyl-[protein] => D-glucosamine(out) + N(pros)-phospho-L-histidyl-[protein]"}
{"X":39102,"RHEA_ID":47270,"compounds":"H2O + monoanhydrobacterioruberin => bacterioruberin"}
{"X":39103,"RHEA_ID":47271,"DIRECTION":"BI","MASTER_ID":47268,"metacyc":"RXN-16709","compounds":"bacterioruberin <=> H2O + monoanhydrobacterioruberin"}
{"X":39104,"RHEA_ID":37364,"DIRECTION":"LR","MASTER_ID":37363,"metacyc":"RXN-14697","compounds":"5 AH2 + 2 H(+) + heme b + 4 O2 => 5 A + beta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O"}
{"X":39105,"RHEA_ID":37365,"compounds":"5 A + beta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O => 5 AH2 + 2 H(+) + heme b + 4 O2"}
{"X":39106,"RHEA_ID":47274,"compounds":"bisanhydrobacterioruberin + H2O => monoanhydrobacterioruberin"}
{"X":39107,"RHEA_ID":57289,"compounds":"an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA + H2O => a guanosine in RNA + H(+) + lactate"}
{"X":39108,"RHEA_ID":37368,"DIRECTION":"LR","MASTER_ID":37367,"metacyc":"RXN-14405","compounds":"CDP-2,3-bis-(O-phytanyl)-sn-glycerol + L-serine => 2,3-bis-O-phytanyl-sn-glycero-3-phospho-L-serine + CMP + H(+)"}
{"X":39109,"RHEA_ID":37369,"compounds":"2,3-bis-O-phytanyl-sn-glycero-3-phospho-L-serine + CMP + H(+) => CDP-2,3-bis-(O-phytanyl)-sn-glycerol + L-serine"}
{"X":39110,"RHEA_ID":47278,"compounds":"15alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":39111,"RHEA_ID":47279,"compounds":"17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 15alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":39112,"RHEA_ID":37372,"compounds":"a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + H2O => a 5'-end (purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methylguanosine 5'-diphosphate"}
{"X":39113,"RHEA_ID":37373,"compounds":"a 5'-end (purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methylguanosine 5'-diphosphate => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + H2O"}
{"X":39114,"RHEA_ID":47283,"compounds":"17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 4-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":39115,"RHEA_ID":37376,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine => 1-(9Z-octadecenoyl)-2-(9Z,12Z-octadienoyl)-sn-glycero-3-phospho-L-serine + CoA"}
{"X":39116,"RHEA_ID":47285,"compounds":"17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":39117,"RHEA_ID":37378,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine <=> 1-(9Z-octadecenoyl)-2-(9Z,12Z-octadienoyl)-sn-glycero-3-phospho-L-serine + CoA"}
{"X":39118,"RHEA_ID":47287,"compounds":"17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":39119,"RHEA_ID":37380,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine => 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA"}
{"X":39120,"RHEA_ID":37381,"compounds":"1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine"}
{"X":39121,"RHEA_ID":37382,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine <=> 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA"}
{"X":39122,"RHEA_ID":47291,"compounds":"17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 7alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":39123,"RHEA_ID":37384,"compounds":"a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39124,"RHEA_ID":47293,"compounds":"estrone + O2 + reduced [NADPH--hemoprotein reductase] => 4-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":39125,"RHEA_ID":37386,"compounds":"a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39126,"RHEA_ID":47295,"compounds":"estrone + O2 + reduced [NADPH--hemoprotein reductase] <=> 4-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":39127,"RHEA_ID":37388,"compounds":"(9Z)-octadecenoyl-CoA + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":39128,"RHEA_ID":47297,"DIRECTION":"LR","MASTER_ID":47296,"metacyc":"RXN-14262","compounds":"dodecanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":39129,"RHEA_ID":37390,"compounds":"(9Z)-octadecenoyl-CoA + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":39130,"RHEA_ID":37391,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1-(9Z)-octadecaenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39131,"RHEA_ID":47300,"compounds":"(9Z)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,9Z)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":39132,"RHEA_ID":47301,"compounds":"(9Z)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,9Z)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":39133,"RHEA_ID":37394,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1-(9Z)-octadecaenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39134,"RHEA_ID":37395,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39135,"RHEA_ID":37396,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39136,"RHEA_ID":47305,"compounds":"(9Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,9Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":39137,"RHEA_ID":37398,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39138,"RHEA_ID":37399,"compounds":"(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine = 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-L-serine + CoA"}
{"X":39139,"RHEA_ID":47308,"compounds":"estrone + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":39140,"RHEA_ID":47309,"compounds":"estrone + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":39141,"RHEA_ID":37402,"compounds":"(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine <=> 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-L-serine + CoA"}
{"X":39142,"RHEA_ID":37403,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serine + CoA"}
{"X":39143,"RHEA_ID":47312,"compounds":"estrone + O2 + reduced [NADPH--hemoprotein reductase] = 15alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":39144,"RHEA_ID":47313,"compounds":"estrone + O2 + reduced [NADPH--hemoprotein reductase] => 15alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":39145,"RHEA_ID":37406,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + octadecanoyl-CoA <=> 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serine + CoA"}
{"X":39146,"RHEA_ID":37407,"compounds":"(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine = 1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + CoA"}
{"X":39147,"RHEA_ID":47316,"compounds":"H(+) + oxidized [electron-transfer flavoprotein] + tetradecanoyl-CoA = (2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":39148,"RHEA_ID":47317,"compounds":"H(+) + oxidized [electron-transfer flavoprotein] + tetradecanoyl-CoA => (2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":39149,"RHEA_ID":37410,"compounds":"(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine <=> 1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + CoA"}
{"X":39150,"RHEA_ID":37411,"DIRECTION":"UN","MASTER_ID":37411,"ec":"1.1.1.362","compounds":"aklavinone + NADP(+) = aklaviketone + 2 H(+) + NADPH"}
{"X":39151,"RHEA_ID":37412,"compounds":"aklavinone + NADP(+) => aklaviketone + 2 H(+) + NADPH"}
{"X":39152,"RHEA_ID":47321,"DIRECTION":"LR","MASTER_ID":47320,"metacyc":"ADP-RIBOSYLARGININE-HYDROLASE-RXN","compounds":"(S)-3-amino-3-phenylpropanoate + 2-oxoglutarate => 3-oxo-3-phenylpropanoate + L-glutamate"}
{"X":39153,"RHEA_ID":47322,"compounds":"3-oxo-3-phenylpropanoate + L-glutamate => (S)-3-amino-3-phenylpropanoate + 2-oxoglutarate"}
{"X":39154,"RHEA_ID":37415,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphoserine + CoA"}
{"X":39155,"RHEA_ID":47324,"compounds":"(S)-3-amino-3-phenylpropanoate + pyruvate = 3-oxo-3-phenylpropanoate + L-alanine"}
{"X":39156,"RHEA_ID":47325,"compounds":"(S)-3-amino-3-phenylpropanoate + pyruvate => 3-oxo-3-phenylpropanoate + L-alanine"}
{"X":39157,"RHEA_ID":37418,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphoserine + CoA"}
{"X":39158,"RHEA_ID":40727,"compounds":"1-hexadecanoylglycerone 3-phosphate + a long-chain fatty acid = a 1-acylglycerone 3-phosphate + hexadecanoate"}
{"X":39159,"RHEA_ID":37420,"compounds":"(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":39160,"RHEA_ID":47329,"compounds":"1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O => (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+)"}
{"X":39161,"RHEA_ID":37422,"compounds":"(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":39162,"RHEA_ID":37423,"DIRECTION":"UN","MASTER_ID":37423,"ec":"1.1.3.45","compounds":"aclacinomycin N + O2 = aclacinomycin A + H2O2"}
{"X":39163,"RHEA_ID":37424,"DIRECTION":"LR","MASTER_ID":37423,"metacyc":"RXN-14689","compounds":"aclacinomycin N + O2 => aclacinomycin A + H2O2"}
{"X":39164,"RHEA_ID":37425,"compounds":"aclacinomycin A + H2O2 => aclacinomycin N + O2"}
{"X":39165,"RHEA_ID":47334,"compounds":"16alpha,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":39166,"RHEA_ID":37427,"compounds":"(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate = a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":39167,"RHEA_ID":47336,"compounds":"17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 16beta,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":39168,"RHEA_ID":37429,"compounds":"a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate"}
{"X":39169,"RHEA_ID":37430,"compounds":"(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate <=> a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":39170,"RHEA_ID":37431,"compounds":"12,18-didecarboxysiroheme + 2 AH2 + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + 2 A + 2 acetate + Fe-coproporphyrin III + 2 H(+) + 2 L-methionine"}
{"X":39171,"RHEA_ID":47340,"compounds":"estrone + O2 + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":39172,"RHEA_ID":47341,"compounds":"estrone + O2 + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":39173,"RHEA_ID":37434,"compounds":"12,18-didecarboxysiroheme + 2 AH2 + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + 2 A + 2 acetate + Fe-coproporphyrin III + 2 H(+) + 2 L-methionine"}
{"X":39174,"RHEA_ID":37435,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphate = a 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA"}
{"X":39175,"RHEA_ID":37436,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphate => a 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA"}
{"X":39176,"RHEA_ID":47345,"compounds":"3beta-hydroxycholest-5-en-7-one + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta,26-dihydroxycholest-5-en-7-one + H2O + 2 oxidized [adrenodoxin]"}
{"X":39177,"RHEA_ID":37438,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphate <=> a 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA"}
{"X":39178,"RHEA_ID":37439,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate = a 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA"}
{"X":39179,"RHEA_ID":47348,"compounds":"butanoate ester + H2O = an aliphatic alcohol + butanoate + H(+)"}
{"X":39180,"RHEA_ID":47349,"compounds":"butanoate ester + H2O => an aliphatic alcohol + butanoate + H(+)"}
{"X":39181,"RHEA_ID":37442,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate <=> a 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA"}
{"X":39182,"RHEA_ID":37443,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA"}
{"X":39183,"RHEA_ID":47352,"compounds":"H2O + hexanoate ester = an aliphatic alcohol + H(+) + hexanoate"}
{"X":39184,"RHEA_ID":47353,"compounds":"H2O + hexanoate ester => an aliphatic alcohol + H(+) + hexanoate"}
{"X":39185,"RHEA_ID":37446,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA"}
{"X":39186,"RHEA_ID":37447,"DIRECTION":"UN","MASTER_ID":37447,"ec":"1.13.12.21","compounds":"O2 + tetracenomycin F1 = H(+) + H2O + tetracenomycin D3"}
{"X":39187,"RHEA_ID":47356,"compounds":"H2O + octanoate ester = an aliphatic alcohol + H(+) + octanoate"}
{"X":39188,"RHEA_ID":37449,"compounds":"H(+) + H2O + tetracenomycin D3 => O2 + tetracenomycin F1"}
{"X":39189,"RHEA_ID":37450,"compounds":"O2 + tetracenomycin F1 <=> H(+) + H2O + tetracenomycin D3"}
{"X":39190,"RHEA_ID":37451,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + eicosanoyl-CoA = 1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphate + CoA"}
{"X":39191,"RHEA_ID":47360,"compounds":"decanoate ester + H2O = an aliphatic alcohol + decanoate + H(+)"}
{"X":39192,"RHEA_ID":37453,"compounds":"1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + eicosanoyl-CoA"}
{"X":39193,"RHEA_ID":40762,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoylglycerone 3-phosphate <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerone 3-phosphate + hexadecanoate"}
{"X":39194,"RHEA_ID":37455,"compounds":"(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}
{"X":39195,"RHEA_ID":47364,"compounds":"dodecanoate ester + H2O = an aliphatic alcohol + dodecanoate + H(+)"}
{"X":39196,"RHEA_ID":37457,"compounds":"1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate"}
{"X":39197,"RHEA_ID":37458,"compounds":"(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate <=> 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}
{"X":39198,"RHEA_ID":37459,"DIRECTION":"UN","MASTER_ID":37459,"ec":"2.7.4.24","compounds":"1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP"}
{"X":39199,"RHEA_ID":47368,"DIRECTION":"UN","MASTER_ID":47368,"ec":"2.4.1.345","compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + GDP-alpha-D-mannose = 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1->2)-D-myo-inositol] + GDP + H(+)"}
{"X":39200,"RHEA_ID":37461,"compounds":"1-diphospho-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP => 1D-myo-inositol hexakisphosphate + ATP"}
{"X":39201,"RHEA_ID":47370,"compounds":"1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1->2)-D-myo-inositol] + GDP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + GDP-alpha-D-mannose"}
{"X":39202,"RHEA_ID":37463,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + sn-glycerol 3-phosphate = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":39203,"RHEA_ID":47372,"DIRECTION":"UN","MASTER_ID":47372,"ec":"1.1.5.9","compounds":"a quinone + D-glucose = a quinol + D-glucono-1,5-lactone"}
{"X":39204,"RHEA_ID":37465,"compounds":"1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + sn-glycerol 3-phosphate"}
{"X":39205,"RHEA_ID":37466,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + sn-glycerol 3-phosphate <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":39206,"RHEA_ID":37467,"DIRECTION":"UN","MASTER_ID":37467,"ec":"2.7.4.21","compounds":"1-diphospho-myo-inositol 2,3,4,5,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP"}
{"X":39207,"RHEA_ID":47376,"compounds":"(25R)-3beta,26-dihydroxycholest-5-en-7-one + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta-hydroxycholest-5-en-7-one-26-al + 2 H2O + 2 oxidized [adrenodoxin]"}
{"X":39208,"RHEA_ID":47377,"compounds":"(25R)-3beta,26-dihydroxycholest-5-en-7-one + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta-hydroxycholest-5-en-7-one-26-al + 2 H2O + 2 oxidized [adrenodoxin]"}
{"X":39209,"RHEA_ID":50753,"DIRECTION":"LR","MASTER_ID":50752,"metacyc":"RXN-18103","compounds":"2 naphthalene-1,2,4,8-tetrol + O2 => 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+) + 2 H2O"}
{"X":39210,"RHEA_ID":47379,"compounds":"(25R)-3beta,26-dihydroxycholest-5-en-7-one + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta-hydroxycholest-5-en-7-one-26-al + 2 H2O + 2 oxidized [adrenodoxin]"}
{"X":39211,"RHEA_ID":37471,"DIRECTION":"UN","MASTER_ID":37471,"ec":"2.3.1.228","compounds":"3-methylbutanoyl-CoA + S-adenosyl-L-methionine = CoA + H(+) + N-isovaleryl-L-homoserine lactone + S-methyl-5'-thioadenosine"}
{"X":39212,"RHEA_ID":40781,"compounds":"L-2-aminopentanoate + NH4(+) => 2-aminopentanenitrile + H(+) + 2 H2O"}
{"X":39213,"RHEA_ID":50757,"compounds":"NADP(+) + reduced [flavodoxin] => 2 H(+) + NADPH + oxidized [flavodoxin]"}
{"X":39214,"RHEA_ID":47383,"compounds":"(25R)-3beta-hydroxycholest-5-en-7-one-26-al + H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta-hydroxycholest-5-en-7-one-26-oate + H2O + 2 oxidized [adrenodoxin]"}
{"X":39215,"RHEA_ID":37475,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":39216,"RHEA_ID":47385,"compounds":"4-acetoxyphenol + H2O => acetate + H(+) + hydroquinone"}
{"X":39217,"RHEA_ID":50761,"DIRECTION":"LR","MASTER_ID":50760,"metacyc":"RXN-15349","compounds":"a quinone + H2O + sulfite => a quinol + sulfate"}
{"X":39218,"RHEA_ID":37478,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":39219,"RHEA_ID":37479,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":39220,"RHEA_ID":40789,"compounds":"CoA + H(+) + tetracosanoate => H2O + tetracosanoyl-CoA"}
{"X":39221,"RHEA_ID":50765,"DIRECTION":"LR","MASTER_ID":50764,"metacyc":"RXN-17977","compounds":"4-amino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine => 4-methylamino-4-dedimethylamino-anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine"}
{"X":39222,"RHEA_ID":37482,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":39223,"RHEA_ID":37483,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-dodecanoyl-sn-glycero-3-phosphocholine = 1-dodecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39224,"RHEA_ID":40793,"compounds":"CoA + H(+) + hexacosanoate => H2O + hexacosanoyl-CoA"}
{"X":39225,"RHEA_ID":37485,"compounds":"1-dodecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-dodecanoyl-sn-glycero-3-phosphocholine"}
{"X":39226,"RHEA_ID":37486,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-dodecanoyl-sn-glycero-3-phosphocholine <=> 1-dodecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39227,"RHEA_ID":37487,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphocholine = 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39228,"RHEA_ID":47397,"compounds":"H2O + octadecanoate ester => an aliphatic alcohol + H(+) + octadecanoate"}
{"X":39229,"RHEA_ID":37489,"compounds":"1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphocholine"}
{"X":39230,"RHEA_ID":37490,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphocholine <=> 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39231,"RHEA_ID":37491,"DIRECTION":"UN","MASTER_ID":37491,"ec":"2.3.1.229","compounds":"4-coumaroyl-CoA + S-adenosyl-L-methionine = CoA + H(+) + N-(4-coumaroyl)-L-homoserine lactone + S-methyl-5'-thioadenosine"}
{"X":39232,"RHEA_ID":57419,"compounds":"H2O + L-asparaginyl-[protein] <=> L-aspartyl-[protein] + NH4(+)"}
{"X":39233,"RHEA_ID":37493,"compounds":"CoA + H(+) + N-(4-coumaroyl)-L-homoserine lactone + S-methyl-5'-thioadenosine => 4-coumaroyl-CoA + S-adenosyl-L-methionine"}
{"X":39234,"RHEA_ID":47403,"compounds":"3-oxo-(9Z-octadecenoyl)-CoA + CoA <=> (7Z)-hexadecenoyl-CoA + acetyl-CoA"}
{"X":39235,"RHEA_ID":37495,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":39236,"RHEA_ID":57423,"compounds":"NADH + 2 oxidized [cytochrome P450] <=> H(+) + NAD(+) + 2 reduced [cytochrome P450]"}
{"X":39237,"RHEA_ID":37497,"compounds":"1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":39238,"RHEA_ID":37498,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":39239,"RHEA_ID":37499,"compounds":"(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":39240,"RHEA_ID":57427,"compounds":"guaiacol + O2 + reduced [NADH--hemoprotein reductase] <=> catechol + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]"}
{"X":39241,"RHEA_ID":37501,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":39242,"RHEA_ID":37502,"compounds":"(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":39243,"RHEA_ID":37503,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":39244,"RHEA_ID":47413,"DIRECTION":"LR","MASTER_ID":47412,"metacyc":"RXN-18608","compounds":"1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1->2)-D-myo-inositol] + an acyl-CoA => 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1->2)-D-myo-inositol] + CoA"}
{"X":39245,"RHEA_ID":47414,"compounds":"1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1->2)-D-myo-inositol] + CoA => 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1->2)-D-myo-inositol] + an acyl-CoA"}
{"X":39246,"RHEA_ID":37506,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":39247,"RHEA_ID":37511,"compounds":"1-dodecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-dodecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39248,"RHEA_ID":37512,"compounds":"1-dodecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-dodecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39249,"RHEA_ID":37513,"compounds":"1-dodecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-dodecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA"}
{"X":39250,"RHEA_ID":37514,"compounds":"1-dodecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-dodecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39251,"RHEA_ID":37515,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + dodecanoyl-CoA = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39252,"RHEA_ID":47421,"compounds":"A + glutaryl-CoA => (2E)-glutaconyl-CoA + AH2"}
{"X":39253,"RHEA_ID":47422,"compounds":"(2E)-glutaconyl-CoA + AH2 => A + glutaryl-CoA"}
{"X":39254,"RHEA_ID":40823,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate"}
{"X":39255,"RHEA_ID":37519,"compounds":"(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":39256,"RHEA_ID":47425,"compounds":"(2E,9Z)-octadecadienoyl-CoA + H2O => (3S)-hydroxy-(9Z-octadecenoyl)-CoA"}
{"X":39257,"RHEA_ID":47426,"compounds":"(3S)-hydroxy-(9Z-octadecenoyl)-CoA => (2E,9Z)-octadecadienoyl-CoA + H2O"}
{"X":39258,"RHEA_ID":37522,"compounds":"(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":39259,"RHEA_ID":37523,"compounds":"(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine = 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":39260,"RHEA_ID":47429,"compounds":"(3S)-hydroxy-(9Z-octadecenoyl)-CoA + NAD(+) => 3-oxo-(9Z-octadecenoyl)-CoA + H(+) + NADH"}
{"X":39261,"RHEA_ID":47430,"compounds":"3-oxo-(9Z-octadecenoyl)-CoA + H(+) + NADH => (3S)-hydroxy-(9Z-octadecenoyl)-CoA + NAD(+)"}
{"X":39262,"RHEA_ID":40831,"compounds":"1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine"}
{"X":39263,"RHEA_ID":37527,"compounds":"1-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39264,"RHEA_ID":47433,"compounds":"(7Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,7Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":39265,"RHEA_ID":47434,"compounds":"(2E,7Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein] => (7Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":39266,"RHEA_ID":37530,"compounds":"1-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39267,"RHEA_ID":37531,"compounds":"(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA"}
{"X":39268,"RHEA_ID":47437,"compounds":"(2E,7Z)-hexadecadienoyl-CoA + H2O => (3S)-hydroxy-(7Z-hexadecenoyl)-CoA"}
{"X":39269,"RHEA_ID":47438,"compounds":"(3S)-hydroxy-(7Z-hexadecenoyl)-CoA => (2E,7Z)-hexadecadienoyl-CoA + H2O"}
{"X":39270,"RHEA_ID":40839,"compounds":"FAD + H(+) + nonanoyl-CoA = (2E)-nonenoyl-CoA + FADH2"}
{"X":39271,"RHEA_ID":37535,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA"}
{"X":39272,"RHEA_ID":47441,"compounds":"(3S)-hydroxy-(7Z-hexadecenoyl)-CoA + NAD(+) => 3-oxo-(7Z-hexadecenoyl)-CoA + H(+) + NADH"}
{"X":39273,"RHEA_ID":47442,"compounds":"3-oxo-(7Z-hexadecenoyl)-CoA + H(+) + NADH => (3S)-hydroxy-(7Z-hexadecenoyl)-CoA + NAD(+)"}
{"X":39274,"RHEA_ID":40843,"compounds":"FAD + H(+) + octadecanoyl-CoA = (2E)-octadecenoyl-CoA + FADH2"}
{"X":39275,"RHEA_ID":37539,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA"}
{"X":39276,"RHEA_ID":47445,"compounds":"3-oxo-(7Z-hexadecenoyl)-CoA + CoA => (5Z)-tetradecenoyl-CoA + acetyl-CoA"}
{"X":39277,"RHEA_ID":47446,"compounds":"(5Z)-tetradecenoyl-CoA + acetyl-CoA => 3-oxo-(7Z-hexadecenoyl)-CoA + CoA"}
{"X":39278,"RHEA_ID":37542,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA"}
{"X":39279,"RHEA_ID":37543,"DIRECTION":"UN","MASTER_ID":37543,"ec":"1.13.11.76","compounds":"2-amino-5-chlorophenol + O2 = 2-amino-5-chloromuconate 6-semialdehyde"}
{"X":39280,"RHEA_ID":47449,"compounds":"(5Z)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,5Z)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":39281,"RHEA_ID":47450,"compounds":"(2E,5Z)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein] => (5Z)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":39282,"RHEA_ID":47451,"compounds":"(5Z)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,5Z)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":39283,"RHEA_ID":37547,"DIRECTION":"UN","MASTER_ID":37547,"ec":"1.1.1.361","compounds":"D-glucose 6-phosphate + NAD(+) = 3-dehydro-D-glucose 6-phosphate + H(+) + NADH"}
{"X":39284,"RHEA_ID":47453,"compounds":"(2E,5Z)-tetradecadienoyl-CoA + H2O => (3S)-hydroxy-(5Z-tetradecenoyl)-CoA"}
{"X":39285,"RHEA_ID":47454,"compounds":"(3S)-hydroxy-(5Z-tetradecenoyl)-CoA => (2E,5Z)-tetradecadienoyl-CoA + H2O"}
{"X":39286,"RHEA_ID":40855,"compounds":"FAD + H(+) + undecanoyl-CoA = FADH2 + trans-2-undecenoyl-CoA"}
{"X":39287,"RHEA_ID":37551,"DIRECTION":"UN","MASTER_ID":37551,"ec":"2.6.1.104","compounds":"3-dehydro-D-glucose 6-phosphate + L-glutamate = 2-oxoglutarate + D-kanosamine 6-phosphate"}
{"X":39288,"RHEA_ID":47457,"compounds":"(3S)-hydroxy-(5Z-tetradecenoyl)-CoA + NAD(+) => 3-oxo-(5Z-tetradecenoyl)-CoA + H(+) + NADH"}
{"X":39289,"RHEA_ID":47458,"compounds":"3-oxo-(5Z-tetradecenoyl)-CoA + H(+) + NADH => (3S)-hydroxy-(5Z-tetradecenoyl)-CoA + NAD(+)"}
{"X":39290,"RHEA_ID":47459,"compounds":"(3S)-hydroxy-(5Z-tetradecenoyl)-CoA + NAD(+) <=> 3-oxo-(5Z-tetradecenoyl)-CoA + H(+) + NADH"}
{"X":39291,"RHEA_ID":37555,"DIRECTION":"UN","MASTER_ID":37555,"ec":"3.1.3.92","compounds":"D-kanosamine 6-phosphate + H2O = kanosamine + phosphate"}
{"X":39292,"RHEA_ID":37556,"DIRECTION":"LR","MASTER_ID":37555,"metacyc":"RXN8J2-138","compounds":"D-kanosamine 6-phosphate + H2O => kanosamine + phosphate"}
{"X":39293,"RHEA_ID":47462,"compounds":"(3Z)-dodecenoyl-CoA + acetyl-CoA => 3-oxo-(5Z-tetradecenoyl)-CoA + CoA"}
{"X":39294,"RHEA_ID":47463,"compounds":"3-oxo-(5Z-tetradecenoyl)-CoA + CoA <=> (3Z)-dodecenoyl-CoA + acetyl-CoA"}
{"X":39295,"RHEA_ID":37559,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":39296,"RHEA_ID":47465,"compounds":"(3E,5Z)-tetradecadienoyl-CoA => (2E,5Z)-tetradecadienoyl-CoA"}
{"X":39297,"RHEA_ID":47466,"compounds":"(2E,5Z)-tetradecadienoyl-CoA => (3E,5Z)-tetradecadienoyl-CoA"}
{"X":39298,"RHEA_ID":37562,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine <=> 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":39299,"RHEA_ID":37563,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39300,"RHEA_ID":37564,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine => 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39301,"RHEA_ID":47470,"compounds":"(3E,5Z)-tetradecadienoyl-CoA => (2E,4E)-tetradecadienoyl-CoA"}
{"X":39302,"RHEA_ID":47471,"compounds":"(2E,4E)-tetradecadienoyl-CoA <=> (3E,5Z)-tetradecadienoyl-CoA"}
{"X":39303,"RHEA_ID":37567,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine = 1-acyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA"}
{"X":39304,"RHEA_ID":37568,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine => 1-acyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA"}
{"X":39305,"RHEA_ID":47474,"compounds":"(3E)-tetradecenoyl-CoA + NADP(+) => (2E,4E)-tetradecadienoyl-CoA + H(+) + NADPH"}
{"X":39306,"RHEA_ID":47475,"compounds":"(2E,4E)-tetradecadienoyl-CoA + H(+) + NADPH <=> (3E)-tetradecenoyl-CoA + NADP(+)"}
{"X":39307,"RHEA_ID":37571,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine = 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA"}
{"X":39308,"RHEA_ID":37572,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine => 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA"}
{"X":39309,"RHEA_ID":47478,"compounds":"(2E)-tetradecenoyl-CoA => (3E)-tetradecenoyl-CoA"}
{"X":39310,"RHEA_ID":47479,"DIRECTION":"BI","MASTER_ID":47476,"metacyc":"RXN-14716","compounds":"(3E)-tetradecenoyl-CoA <=> (2E)-tetradecenoyl-CoA"}
{"X":39311,"RHEA_ID":37575,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine = 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":39312,"RHEA_ID":37576,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine => 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":39313,"RHEA_ID":37577,"compounds":"1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine"}
{"X":39314,"RHEA_ID":47483,"compounds":"deoxycholate + NADP(+) <=> 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH"}
{"X":39315,"RHEA_ID":37579,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine = 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":39316,"RHEA_ID":37580,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine => 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":39317,"RHEA_ID":47486,"compounds":"12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH => deoxycholate + NAD(+)"}
{"X":39318,"RHEA_ID":37582,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine <=> 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":39319,"RHEA_ID":37583,"DIRECTION":"UN","MASTER_ID":37583,"ec":"1.4.3.3","compounds":"D-lysine + H2O + O2 = 6-amino-2-oxohexanoate + H2O2 + NH4(+)"}
{"X":39320,"RHEA_ID":37584,"DIRECTION":"LR","MASTER_ID":37583,"metacyc":"RXN-8163","compounds":"D-lysine + H2O + O2 => 6-amino-2-oxohexanoate + H2O2 + NH4(+)"}
{"X":39321,"RHEA_ID":47490,"compounds":"isodeoxycholate + NADP(+) => 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH"}
{"X":39322,"RHEA_ID":37586,"compounds":"D-lysine + H2O + O2 <=> 6-amino-2-oxohexanoate + H2O2 + NH4(+)"}
{"X":39323,"RHEA_ID":37587,"compounds":"2-oxoglutarate + D-lysine = 6-amino-2-oxohexanoate + L-glutamate"}
{"X":39324,"RHEA_ID":37588,"compounds":"2-oxoglutarate + D-lysine => 6-amino-2-oxohexanoate + L-glutamate"}
{"X":39325,"RHEA_ID":37589,"compounds":"6-amino-2-oxohexanoate + L-glutamate => 2-oxoglutarate + D-lysine"}
{"X":39326,"RHEA_ID":47495,"compounds":"12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH <=> isodeoxycholate + NAD(+)"}
{"X":39327,"RHEA_ID":37591,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + dodecanoyl-CoA = 1-(9Z)-octadecenoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":39328,"RHEA_ID":37592,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + dodecanoyl-CoA => 1-(9Z)-octadecenoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":39329,"RHEA_ID":47498,"compounds":"3-oxo-5beta-cholan-24-oate + H(+) + NADPH => lithocholate + NADP(+)"}
{"X":39330,"RHEA_ID":57525,"compounds":"a 5'-triphospho-guanosine-ribonucleotide-tRNA(His) + H2O => a 5'-phospho-guanosine-ribonucleotide-tRNA(His) + diphosphate + H(+)"}
{"X":39331,"RHEA_ID":37595,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + nonadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-nonadecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":39332,"RHEA_ID":37596,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + nonadecanoyl-CoA => 1-(9Z)-octadecenoyl-2-nonadecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":39333,"RHEA_ID":37597,"compounds":"1-(9Z)-octadecenoyl-2-nonadecanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + nonadecanoyl-CoA"}
{"X":39334,"RHEA_ID":37598,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + nonadecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-nonadecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":39335,"RHEA_ID":37599,"DIRECTION":"UN","MASTER_ID":37599,"ec":"1.14.19.13","compounds":"(9Z,12Z)-hexadecadienoyl-CoA + AH2 + O2 = (9Z,12Z,15Z)-hexadecatrienoyl-CoA + A + 2 H2O"}
{"X":39336,"RHEA_ID":37600,"compounds":"(9Z,12Z)-hexadecadienoyl-CoA + AH2 + O2 => (9Z,12Z,15Z)-hexadecatrienoyl-CoA + A + 2 H2O"}
{"X":39337,"RHEA_ID":37601,"compounds":"(9Z,12Z,15Z)-hexadecatrienoyl-CoA + A + 2 H2O => (9Z,12Z)-hexadecadienoyl-CoA + AH2 + O2"}
{"X":39338,"RHEA_ID":57533,"compounds":"5'-end ribonucleotide-RNA + ATP + H(+) => adenosine-5'-diphospho-5'-ribonucleotide-RNA + diphosphate"}
{"X":39339,"RHEA_ID":47508,"DIRECTION":"UN","MASTER_ID":47508,"ec":"1.1.1.391","compounds":"3-oxo-5beta-cholan-24-oate + H(+) + NADH = isolithocholate + NAD(+)"}
{"X":39340,"RHEA_ID":37604,"compounds":"(11Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1-(9Z)-octadecenoyl-2-(11Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}
{"X":39341,"RHEA_ID":37605,"compounds":"1-(9Z)-octadecenoyl-2-(11Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (11Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate"}
{"X":39342,"RHEA_ID":37606,"compounds":"(11Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1-(9Z)-octadecenoyl-2-(11Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}
{"X":39343,"RHEA_ID":37607,"compounds":"(6Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(6Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}
{"X":39344,"RHEA_ID":37608,"compounds":"(6Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1-(9Z)-octadecenoyl-2-(6Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}
{"X":39345,"RHEA_ID":37609,"compounds":"1-(9Z)-octadecenoyl-2-(6Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (6Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate"}
{"X":39346,"RHEA_ID":37610,"compounds":"(6Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1-(9Z)-octadecenoyl-2-(6Z)-octadecenoyl-sn-glycero-3-phosphate + CoA"}
{"X":39347,"RHEA_ID":57542,"compounds":"5'-phospho-ribonucleosidyl-ribonucleotide-RNA + diphosphate + H(+) => 5'-NTP-ribonucleotide-RNA + H2O"}
{"X":39348,"RHEA_ID":50892,"compounds":"a menaquinone + 2 H(+) + hydrogen sulfide + sulfite = a menaquinol + thiosulfate"}
{"X":39349,"RHEA_ID":37613,"compounds":"1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho]-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol"}
{"X":39350,"RHEA_ID":37614,"compounds":"(9Z)-octadecenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":39351,"RHEA_ID":37615,"compounds":"(9Z)-octadecenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":39352,"RHEA_ID":37616,"compounds":"(9Z)-octadecenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol => 1'-[1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":39353,"RHEA_ID":47522,"compounds":"isolithocholate + NADP(+) => 3-oxo-5beta-cholan-24-oate + H(+) + NADPH"}
{"X":39354,"RHEA_ID":37618,"compounds":"(9Z)-octadecenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol <=> 1'-[1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":39355,"RHEA_ID":47524,"compounds":"cholate + NAD(+) = 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH"}
{"X":39356,"RHEA_ID":37620,"compounds":"(9Z)-octadecenoyl-CoA + 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":39357,"RHEA_ID":47526,"compounds":"7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH => cholate + NAD(+)"}
{"X":39358,"RHEA_ID":37622,"compounds":"(9Z)-octadecenoyl-CoA + 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":39359,"RHEA_ID":37623,"compounds":"(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) = a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}
{"X":39360,"RHEA_ID":37624,"compounds":"(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) => a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}
{"X":39361,"RHEA_ID":37625,"compounds":"a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol)"}
{"X":39362,"RHEA_ID":37626,"compounds":"(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}
{"X":39363,"RHEA_ID":47532,"compounds":"chenodeoxycholate + NAD(+) = 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH"}
{"X":39364,"RHEA_ID":37628,"compounds":"(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine => 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39365,"RHEA_ID":47534,"compounds":"7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH => chenodeoxycholate + NAD(+)"}
{"X":39366,"RHEA_ID":37630,"compounds":"(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine <=> 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39367,"RHEA_ID":37631,"compounds":"(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":39368,"RHEA_ID":37632,"compounds":"(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine => 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":39369,"RHEA_ID":47538,"compounds":"isochenodeoxycholate + NADP(+) => 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH"}
{"X":39370,"RHEA_ID":37634,"compounds":"(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine <=> 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":39371,"RHEA_ID":47540,"compounds":"7-oxolithocholate + H(+) + NADPH = NADP(+) + ursodeoxycholate"}
{"X":39372,"RHEA_ID":37636,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine => 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":39373,"RHEA_ID":47542,"compounds":"NADP(+) + ursodeoxycholate => 7-oxolithocholate + H(+) + NADPH"}
{"X":39374,"RHEA_ID":37638,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine <=> 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":39375,"RHEA_ID":47544,"DIRECTION":"UN","MASTER_ID":47544,"ec":"5.1.1.22","compounds":"trans-4-hydroxy-L-proline betaine = cis-4-hydroxy-D-proline betaine"}
{"X":39376,"RHEA_ID":37640,"compounds":"1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + dodecanoyl-CoA => 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}
{"X":39377,"RHEA_ID":47546,"compounds":"cis-4-hydroxy-D-proline betaine => trans-4-hydroxy-L-proline betaine"}
{"X":39378,"RHEA_ID":37642,"compounds":"1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + dodecanoyl-CoA <=> 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}
{"X":39379,"RHEA_ID":47548,"compounds":"7alpha-hydroxy-3-oxochol-4-en-24-oate = 3-oxochola-4,6-dien-24-oate + H2O"}
{"X":39380,"RHEA_ID":37644,"compounds":"(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":39381,"RHEA_ID":47550,"compounds":"3-oxochola-4,6-dien-24-oate + H2O => 7alpha-hydroxy-3-oxochol-4-en-24-oate"}
{"X":39382,"RHEA_ID":37646,"compounds":"(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":39383,"RHEA_ID":37647,"compounds":"(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":39384,"RHEA_ID":37648,"compounds":"(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":39385,"RHEA_ID":47554,"compounds":"deoxycholate + glycine => glycodeoxycholate + H2O"}
{"X":39386,"RHEA_ID":37650,"compounds":"(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":39387,"RHEA_ID":47556,"compounds":"H2O + taurodeoxycholate = deoxycholate + taurine"}
{"X":39388,"RHEA_ID":37652,"compounds":"(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":39389,"RHEA_ID":47558,"compounds":"deoxycholate + taurine => H2O + taurodeoxycholate"}
{"X":39390,"RHEA_ID":37654,"compounds":"(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":39391,"RHEA_ID":47560,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)) = CMP + ganglioside GM1b (d18:1(4E)) + H(+)"}
{"X":39392,"RHEA_ID":37656,"compounds":"1-tetradecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39393,"RHEA_ID":47562,"compounds":"CMP + ganglioside GM1b (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E))"}
{"X":39394,"RHEA_ID":37658,"compounds":"1-tetradecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39395,"RHEA_ID":47564,"compounds":"a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = ganglioside GA2 (d18:1(4E)) + H(+) + UDP"}
{"X":39396,"RHEA_ID":37660,"compounds":"anthraniloyl-CoA + methanol => CoA + O-methyl anthranilate"}
{"X":39397,"RHEA_ID":47566,"compounds":"ganglioside GA2 (d18:1(4E)) + H(+) + UDP => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine"}
{"X":39398,"RHEA_ID":47567,"compounds":"a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> ganglioside GA2 (d18:1(4E)) + H(+) + UDP"}
{"X":39399,"RHEA_ID":47568,"compounds":"ganglioside GD2 (d18:1(4E)) + UDP-alpha-D-galactose = ganglioside GD1b (d18:1(4E)) + H(+) + UDP"}
{"X":39400,"RHEA_ID":37664,"compounds":"3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP"}
{"X":39401,"RHEA_ID":37665,"compounds":"3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP => 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":39402,"RHEA_ID":47571,"compounds":"ganglioside GD2 (d18:1(4E)) + UDP-alpha-D-galactose <=> ganglioside GD1b (d18:1(4E)) + H(+) + UDP"}
{"X":39403,"RHEA_ID":47572,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GD1b (d18:1(4E)) = CMP + ganglioside GT1b (d18:1(4E)) + H(+)"}
{"X":39404,"RHEA_ID":37668,"compounds":"3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine => 3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP"}
{"X":39405,"RHEA_ID":37669,"compounds":"3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP => 3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine"}
{"X":39406,"RHEA_ID":47575,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GD1b (d18:1(4E)) <=> CMP + ganglioside GT1b (d18:1(4E)) + H(+)"}
{"X":39407,"RHEA_ID":37675,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":39408,"RHEA_ID":37676,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":39409,"RHEA_ID":47578,"compounds":"CMP + ganglioside GD1c (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM1b (d18:1(4E))"}
{"X":39410,"RHEA_ID":37678,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":39411,"RHEA_ID":47580,"compounds":"ganglioside GT3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = ganglioside GT2 (d18:1(4E)) + H(+) + UDP"}
{"X":39412,"RHEA_ID":37680,"compounds":"1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-dodecanoyl-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":39413,"RHEA_ID":47582,"compounds":"ganglioside GT2 (d18:1(4E)) + H(+) + UDP => ganglioside GT3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine"}
{"X":39414,"RHEA_ID":37682,"compounds":"1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-dodecanoyl-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":39415,"RHEA_ID":37683,"compounds":"1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA = 1'-[1-acyl-2-dodecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":39416,"RHEA_ID":47585,"compounds":"ganglioside GT2 (d18:1(4E)) + UDP-alpha-D-galactose => ganglioside GT1c (d18:1(4E)) + H(+) + UDP"}
{"X":39417,"RHEA_ID":47586,"compounds":"ganglioside GT1c (d18:1(4E)) + H(+) + UDP => ganglioside GT2 (d18:1(4E)) + UDP-alpha-D-galactose"}
{"X":39418,"RHEA_ID":37686,"compounds":"1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA <=> 1'-[1-acyl-2-dodecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":39419,"RHEA_ID":37687,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":39420,"RHEA_ID":47589,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GT1c (d18:1(4E)) => CMP + ganglioside GQ1c (d18:1(4E)) + H(+)"}
{"X":39421,"RHEA_ID":37689,"compounds":"1'-[1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol"}
{"X":39422,"RHEA_ID":37690,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol <=> 1'-[1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":39423,"RHEA_ID":37691,"compounds":"1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA = 1'-[1-acyl-2-hexadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":39424,"RHEA_ID":47593,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GQ1c (d18:1(4E)) => CMP + ganglioside GP1c (d18:1(4E)) + H(+)"}
{"X":39425,"RHEA_ID":47594,"compounds":"CMP + ganglioside GP1c (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GQ1c (d18:1(4E))"}
{"X":39426,"RHEA_ID":37694,"compounds":"1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA <=> 1'-[1-acyl-2-hexadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":39427,"RHEA_ID":37695,"compounds":"1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octadecanoyl-CoA = 1'-[1-acyl-2-octadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":39428,"RHEA_ID":37696,"compounds":"1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octadecanoyl-CoA => 1'-[1-acyl-2-octadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":39429,"RHEA_ID":47598,"compounds":"an archaeal dolichyl 3-O-(2,3-diacetamido-2,3-dideoxy- beta-D-glucuronosyl)-N-acetyl- alpha-D-glucosaminyl phosphate + H(+) + UDP => an archaeal dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate"}
{"X":39430,"RHEA_ID":37698,"compounds":"1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octadecanoyl-CoA <=> 1'-[1-acyl-2-octadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":39431,"RHEA_ID":37699,"compounds":"1-O-octadecyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39432,"RHEA_ID":47601,"compounds":"a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + CMP-N-acetyl-beta-neuraminate => CMP + ganglioside GM4 (d18:1(4E)) + H(+)"}
{"X":39433,"RHEA_ID":47602,"compounds":"CMP + ganglioside GM4 (d18:1(4E)) + H(+) => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + CMP-N-acetyl-beta-neuraminate"}
{"X":39434,"RHEA_ID":37702,"compounds":"1-O-octadecyl-sn-glycero-3-phosphocholine + acetyl-CoA <=> 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39435,"RHEA_ID":37703,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39436,"RHEA_ID":47605,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GQ1c (d18:1(4E)) => CMP + ganglioside GP1calpha (d18:1(4E)) + H(+)"}
{"X":39437,"RHEA_ID":47606,"compounds":"CMP + ganglioside GP1calpha (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GQ1c (d18:1(4E))"}
{"X":39438,"RHEA_ID":37706,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA <=> 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39439,"RHEA_ID":37707,"compounds":"1-octadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39440,"RHEA_ID":37708,"compounds":"1-octadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA => 1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39441,"RHEA_ID":47610,"compounds":"3,3',5-trihydroxybibenzyl + 4 CO2 + 4 CoA => 3-(3-hydroxyphenyl)-propanoyl-CoA + 3 H(+) + 3 malonyl-CoA"}
{"X":39442,"RHEA_ID":37710,"compounds":"1-octadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA <=> 1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39443,"RHEA_ID":37711,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + acetyl-CoA = 1-O-(1Z)-alkenyl-2-acetyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39444,"RHEA_ID":47613,"DIRECTION":"LR","MASTER_ID":47612,"metacyc":"2.4.1.157-RXN","compounds":"a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose => a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + H(+) + UDP"}
{"X":39445,"RHEA_ID":47614,"compounds":"a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + H(+) + UDP => a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose"}
{"X":39446,"RHEA_ID":37714,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + acetyl-CoA <=> 1-O-(1Z)-alkenyl-2-acetyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39447,"RHEA_ID":37715,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-alkyl-sn-glycero-3-phosphocholine = 1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39448,"RHEA_ID":37716,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-alkyl-sn-glycero-3-phosphocholine => 1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39449,"RHEA_ID":47618,"compounds":"ethionamide S-oxide + H2O + NADP(+) => ethionamide + H(+) + NADPH + O2"}
{"X":39450,"RHEA_ID":37718,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-alkyl-sn-glycero-3-phosphocholine <=> 1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39451,"RHEA_ID":37719,"compounds":"1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39452,"RHEA_ID":37720,"compounds":"1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39453,"RHEA_ID":37721,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA => 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA"}
{"X":39454,"RHEA_ID":37722,"compounds":"1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA <=> 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39455,"RHEA_ID":37723,"compounds":"(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39456,"RHEA_ID":47625,"DIRECTION":"LR","MASTER_ID":47624,"metacyc":"RXN-18503","compounds":"cis-3-hydroxy-L-proline => 1-pyrroline-2-carboxylate + H2O"}
{"X":39457,"RHEA_ID":47626,"compounds":"1-pyrroline-2-carboxylate + H2O => cis-3-hydroxy-L-proline"}
{"X":39458,"RHEA_ID":37726,"compounds":"(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine <=> 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39459,"RHEA_ID":37727,"compounds":"(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine = 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":39460,"RHEA_ID":47629,"compounds":"glyoxylate + H2O + propanoyl-CoA => 3-methylmalate + CoA + H(+)"}
{"X":39461,"RHEA_ID":47630,"compounds":"3-methylmalate + CoA + H(+) => glyoxylate + H2O + propanoyl-CoA"}
{"X":39462,"RHEA_ID":37730,"compounds":"(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine <=> 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":39463,"RHEA_ID":37731,"compounds":"(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine = 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":39464,"RHEA_ID":47633,"compounds":"H2O + L-arginine + NAD(+) => 5-guanidino-2-oxopentanoate + H(+) + NADH + NH4(+)"}
{"X":39465,"RHEA_ID":47634,"DIRECTION":"RL","MASTER_ID":47632,"metacyc":"RXN-11194","compounds":"5-guanidino-2-oxopentanoate + H(+) + NADH + NH4(+) => H2O + L-arginine + NAD(+)"}
{"X":39466,"RHEA_ID":37734,"compounds":"(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine <=> 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":39467,"RHEA_ID":37735,"compounds":"(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine = 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA"}
{"X":39468,"RHEA_ID":47637,"compounds":"H2O + L-arginine + NADP(+) => 5-guanidino-2-oxopentanoate + H(+) + NADPH + NH4(+)"}
{"X":39469,"RHEA_ID":47638,"DIRECTION":"RL","MASTER_ID":47636,"metacyc":"RXN-11194","compounds":"5-guanidino-2-oxopentanoate + H(+) + NADPH + NH4(+) => H2O + L-arginine + NADP(+)"}
{"X":39470,"RHEA_ID":37738,"compounds":"(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine <=> 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA"}
{"X":39471,"RHEA_ID":37739,"compounds":"(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine = 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoserine + CoA"}
{"X":39472,"RHEA_ID":47641,"compounds":"adenosine(1785)/adenosine(1786) in 18S rRNA + 4 S-adenosyl-L-methionine => 4 H(+) + N(6)-dimethyladenosine(1785)/N(6)-dimethyladenosine(1786) in 18S rRNA + 4 S-adenosyl-L-homocysteine"}
{"X":39473,"RHEA_ID":47642,"compounds":"4 H(+) + N(6)-dimethyladenosine(1785)/N(6)-dimethyladenosine(1786) in 18S rRNA + 4 S-adenosyl-L-homocysteine => adenosine(1785)/adenosine(1786) in 18S rRNA + 4 S-adenosyl-L-methionine"}
{"X":39474,"RHEA_ID":37742,"compounds":"(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine <=> 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoserine + CoA"}
{"X":39475,"RHEA_ID":37743,"DIRECTION":"UN","MASTER_ID":37743,"ec":"2.5.1.129","compounds":"dimethylallyl phosphate + FMNH2 = phosphate + prenyl-FMNH2"}
{"X":39476,"RHEA_ID":47645,"compounds":"adenosine(1914)/adenosine(1915) in 18S rRNA + 4 S-adenosyl-L-methionine => 4 H(+) + N(6)-dimethyladenosine(1914)/N(6)-dimethyladenosine(1915) in 18S rRNA + 4 S-adenosyl-L-homocysteine"}
{"X":39477,"RHEA_ID":47646,"compounds":"4 H(+) + N(6)-dimethyladenosine(1914)/N(6)-dimethyladenosine(1915) in 18S rRNA + 4 S-adenosyl-L-homocysteine => adenosine(1914)/adenosine(1915) in 18S rRNA + 4 S-adenosyl-L-methionine"}
{"X":39478,"RHEA_ID":47647,"compounds":"adenosine(1914)/adenosine(1915) in 18S rRNA + 4 S-adenosyl-L-methionine <=> 4 H(+) + N(6)-dimethyladenosine(1914)/N(6)-dimethyladenosine(1915) in 18S rRNA + 4 S-adenosyl-L-homocysteine"}
{"X":39479,"RHEA_ID":37747,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-octadecyl-sn-glycero-3-phosphocholine = 1-O-octadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39480,"RHEA_ID":47649,"compounds":"D-ribitol 5-phosphate + H2O => phosphate + ribitol"}
{"X":39481,"RHEA_ID":47650,"compounds":"phosphate + ribitol => D-ribitol 5-phosphate + H2O"}
{"X":39482,"RHEA_ID":37750,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-octadecyl-sn-glycero-3-phosphocholine <=> 1-O-octadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39483,"RHEA_ID":37751,"compounds":"2-methyl-trans-aconitate = 2-methyl-cis-aconitate"}
{"X":39484,"RHEA_ID":47653,"compounds":"D-ribitol 1-phosphate + H2O => phosphate + ribitol"}
{"X":39485,"RHEA_ID":47654,"compounds":"phosphate + ribitol => D-ribitol 1-phosphate + H2O"}
{"X":39486,"RHEA_ID":37754,"compounds":"2-methyl-trans-aconitate <=> 2-methyl-cis-aconitate"}
{"X":39487,"RHEA_ID":37755,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":39488,"RHEA_ID":47657,"compounds":"acetyl-CoA + L-methionine sulfone => CoA + H(+) + N-acetyl-L-methionine sulfone"}
{"X":39489,"RHEA_ID":37757,"compounds":"1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA"}
{"X":39490,"RHEA_ID":37758,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA <=> 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":39491,"RHEA_ID":37759,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-O-(1Z)-alkenyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":39492,"RHEA_ID":47661,"compounds":"acetyl-CoA + L-methionine sulfoximine => CoA + H(+) + N-acetyl-L-methionine sulfoximine"}
{"X":39493,"RHEA_ID":47662,"compounds":"CoA + H(+) + N-acetyl-L-methionine sulfoximine => acetyl-CoA + L-methionine sulfoximine"}
{"X":39494,"RHEA_ID":37762,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA <=> 1-O-(1Z)-alkenyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":39495,"RHEA_ID":37763,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octanoyl-CoA = 1-O-(1Z)-alkenyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":39496,"RHEA_ID":47665,"compounds":"H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD(+) => 2''-O-glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide"}
{"X":39497,"RHEA_ID":37765,"compounds":"1-O-(1Z)-alkenyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octanoyl-CoA"}
{"X":39498,"RHEA_ID":37766,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octanoyl-CoA <=> 1-O-(1Z)-alkenyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":39499,"RHEA_ID":37767,"compounds":"a 1-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":39500,"RHEA_ID":37768,"compounds":"a 1-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA => 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":39501,"RHEA_ID":37769,"compounds":"1-acyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => a 1-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA"}
{"X":39502,"RHEA_ID":37770,"compounds":"a 1-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA <=> 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":39503,"RHEA_ID":37771,"compounds":"a 1-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-acyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":39504,"RHEA_ID":47673,"compounds":"H2O + N(6)-malonyl-L-lysyl-[protein] + NAD(+) => 2''-O-malonyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide"}
{"X":39505,"RHEA_ID":37773,"compounds":"1-acyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => a 1-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA"}
{"X":39506,"RHEA_ID":37774,"compounds":"a 1-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA <=> 1-acyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":39507,"RHEA_ID":37775,"compounds":"a 1-acyl-sn-glycero-3-phosphoethanolamine + octanoyl-CoA = 1-acyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":39508,"RHEA_ID":37776,"compounds":"a 1-acyl-sn-glycero-3-phosphoethanolamine + octanoyl-CoA => 1-acyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":39509,"RHEA_ID":37777,"compounds":"1-acyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA => a 1-acyl-sn-glycero-3-phosphoethanolamine + octanoyl-CoA"}
{"X":39510,"RHEA_ID":37778,"compounds":"a 1-acyl-sn-glycero-3-phosphoethanolamine + octanoyl-CoA <=> 1-acyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":39511,"RHEA_ID":37779,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":39512,"RHEA_ID":47681,"DIRECTION":"LR","MASTER_ID":47680,"metacyc":"RXN-13548","compounds":"D-galactosamine 6-phosphate + H2O => D-tagatose 6-phosphate + NH4(+)"}
{"X":39513,"RHEA_ID":37781,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)"}
{"X":39514,"RHEA_ID":37782,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":39515,"RHEA_ID":37783,"compounds":"(9Z)-octadecenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine = 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39516,"RHEA_ID":37784,"compounds":"(9Z)-octadecenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine => 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39517,"RHEA_ID":47686,"compounds":"[(1->2)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate => [(1->2)-beta-D-glucosyl](n) + phosphate"}
{"X":39518,"RHEA_ID":37786,"compounds":"(9Z)-octadecenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine <=> 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39519,"RHEA_ID":37787,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39520,"RHEA_ID":47689,"compounds":"cis-4-hydroxy-L-proline + NADP(+) => Delta(1)-pyrroline-(4S)-hydroxy-2-carboxylate + 2 H(+) + NADPH"}
{"X":39521,"RHEA_ID":37789,"compounds":"1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine"}
{"X":39522,"RHEA_ID":37790,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine <=> 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39523,"RHEA_ID":37791,"DIRECTION":"UN","MASTER_ID":37791,"ec":"1.3.3.14","compounds":"aclacinomycin A + O2 = aclacinomycin Y + H2O2"}
{"X":39524,"RHEA_ID":47693,"compounds":"AH2 + neomycin C + S-adenosyl-L-methionine => 5'-deoxyadenosine + A + H(+) + L-methionine + neomycin B"}
{"X":39525,"RHEA_ID":37793,"compounds":"aclacinomycin Y + H2O2 => aclacinomycin A + O2"}
{"X":39526,"RHEA_ID":47695,"compounds":"AH2 + neomycin C + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + A + H(+) + L-methionine + neomycin B"}
{"X":39527,"RHEA_ID":37795,"DIRECTION":"UN","MASTER_ID":37795,"ec":"1.6.3.2","compounds":"2 H(+) + 2 NADPH + O2 = 2 H2O + 2 NADP(+)"}
{"X":39528,"RHEA_ID":47697,"DIRECTION":"LR","MASTER_ID":47696,"metacyc":"RXN-12039","compounds":"(2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + H2O => (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + phosphate"}
{"X":39529,"RHEA_ID":47698,"compounds":"(2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + phosphate => (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + H2O"}
{"X":39530,"RHEA_ID":37798,"compounds":"2 H(+) + 2 NADPH + O2 <=> 2 H2O + 2 NADP(+)"}
{"X":39531,"RHEA_ID":37799,"DIRECTION":"UN","MASTER_ID":37799,"ec":"1.6.3.2","compounds":"2 H(+) + 2 NADH + O2 = 2 H2O + 2 NAD(+)"}
{"X":39532,"RHEA_ID":47701,"compounds":"H(+) + ketocytochalasin + NADPH + O2 => H2O + iso-precytochalasin + NADP(+)"}
{"X":39533,"RHEA_ID":47702,"compounds":"H2O + iso-precytochalasin + NADP(+) => H(+) + ketocytochalasin + NADPH + O2"}
{"X":39534,"RHEA_ID":37800,"DIRECTION":"LR","MASTER_ID":37799,"metacyc":"RXN-14692","compounds":"2 H(+) + 2 NADH + O2 => 2 H2O + 2 NAD(+)"}
{"X":39535,"RHEA_ID":37801,"compounds":"2 H2O + 2 NAD(+) => 2 H(+) + 2 NADH + O2"}
{"X":39536,"RHEA_ID":47705,"compounds":"H(+) + iso-precytochalasin + NADPH + O2 => cytochalasin Z16 + H2O + NADP(+)"}
{"X":39537,"RHEA_ID":37803,"compounds":"a 1-acyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39538,"RHEA_ID":37804,"compounds":"a 1-acyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39539,"RHEA_ID":37805,"compounds":"1-acyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => a 1-acyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA"}
{"X":39540,"RHEA_ID":47709,"compounds":"ADP + alpha-D-glucose 1-phosphate + H(+) => ADP-alpha-D-glucose + phosphate"}
{"X":39541,"RHEA_ID":37807,"compounds":"1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":39542,"RHEA_ID":37808,"compounds":"1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA => 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":39543,"RHEA_ID":37809,"compounds":"1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA"}
{"X":39544,"RHEA_ID":47713,"compounds":"trans-3-hydroxy-L-proline => cis-3-hydroxy-D-proline"}
{"X":39545,"RHEA_ID":47714,"compounds":"cis-3-hydroxy-D-proline => trans-3-hydroxy-L-proline"}
{"X":39546,"RHEA_ID":37812,"compounds":"1-O-hexadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39547,"RHEA_ID":37813,"compounds":"1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-O-hexadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA"}
{"X":39548,"RHEA_ID":47717,"compounds":"4-pregnen-20,21-diol-3-one + NAD(+) => 21-hydroxyprogesterone + H(+) + NADH"}
{"X":39549,"RHEA_ID":47718,"compounds":"21-hydroxyprogesterone + H(+) + NADH => 4-pregnen-20,21-diol-3-one + NAD(+)"}
{"X":39550,"RHEA_ID":37816,"DIRECTION":"LR","MASTER_ID":37815,"metacyc":"RXN-14822","compounds":"(R)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2 => 2-methyl-4-chlorophenol + CO2 + pyruvate + succinate"}
{"X":39551,"RHEA_ID":37817,"compounds":"2-methyl-4-chlorophenol + CO2 + pyruvate + succinate => (R)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2"}
{"X":39552,"RHEA_ID":57755,"compounds":"2 (S)-methylmalonyl-CoA + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH <=> C34-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)"}
{"X":39553,"RHEA_ID":37819,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39554,"RHEA_ID":37820,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39555,"RHEA_ID":37821,"compounds":"1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA"}
{"X":39556,"RHEA_ID":47725,"DIRECTION":"LR","MASTER_ID":47724,"ecocyc":"RXN-19024","metacyc":"RXN-19024","reactome":"R-HSA-6785928.2","compounds":"glutathione => 5-oxo-L-proline + L-cysteinylglycine"}
{"X":39557,"RHEA_ID":47726,"compounds":"5-oxo-L-proline + L-cysteinylglycine => glutathione"}
{"X":39558,"RHEA_ID":37824,"DIRECTION":"LR","MASTER_ID":37823,"metacyc":"RXN-14823","compounds":"(R)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 => 2,4-dichlorophenol + CO2 + pyruvate + succinate"}
{"X":39559,"RHEA_ID":37825,"compounds":"2,4-dichlorophenol + CO2 + pyruvate + succinate => (R)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2"}
{"X":39560,"RHEA_ID":57763,"compounds":"2 (S)-methylmalonyl-CoA + 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH <=> C37-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)"}
{"X":39561,"RHEA_ID":37827,"DIRECTION":"UN","MASTER_ID":37827,"ec":"1.14.11.43","compounds":"(S)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 = 2,4-dichlorophenol + CO2 + pyruvate + succinate"}
{"X":39562,"RHEA_ID":37828,"DIRECTION":"LR","MASTER_ID":37827,"metacyc":"RXN-14821","compounds":"(S)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 => 2,4-dichlorophenol + CO2 + pyruvate + succinate"}
{"X":39563,"RHEA_ID":37829,"compounds":"2,4-dichlorophenol + CO2 + pyruvate + succinate => (S)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2"}
{"X":39564,"RHEA_ID":47733,"compounds":"cytidine(1400) in 16S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(1400) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":39565,"RHEA_ID":37831,"DIRECTION":"UN","MASTER_ID":37831,"ec":"1.14.11.43","compounds":"(S)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2 = 2-methyl-4-chlorophenol + CO2 + pyruvate + succinate"}
{"X":39566,"RHEA_ID":37832,"DIRECTION":"LR","MASTER_ID":37831,"metacyc":"RXN-14820","compounds":"(S)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2 => 2-methyl-4-chlorophenol + CO2 + pyruvate + succinate"}
{"X":39567,"RHEA_ID":37833,"compounds":"2-methyl-4-chlorophenol + CO2 + pyruvate + succinate => (S)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2"}
{"X":39568,"RHEA_ID":57771,"compounds":"2-nitrotoluene + NADH + O2 <=> 3-methylcatechol + NAD(+) + nitrite"}
{"X":39569,"RHEA_ID":47738,"compounds":"5-methylcytidine(1404) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1404) in 16S rRNA + S-adenosyl-L-methionine"}
{"X":39570,"RHEA_ID":37836,"DIRECTION":"LR","MASTER_ID":37835,"metacyc":"RXN-14824","compounds":"aklavinone + H(+) + NADPH + O2 => epsilon-rhodomycinone + H2O + NADP(+)"}
{"X":39571,"RHEA_ID":37837,"compounds":"epsilon-rhodomycinone + H2O + NADP(+) => aklavinone + H(+) + NADPH + O2"}
{"X":39572,"RHEA_ID":57775,"compounds":"3-nitrotoluene + NADH + O2 <=> 4-methylcatechol + NAD(+) + nitrite"}
{"X":39573,"RHEA_ID":37839,"compounds":"1-O-octadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-O-octadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39574,"RHEA_ID":37840,"compounds":"1-O-octadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-O-octadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39575,"RHEA_ID":37841,"compounds":"1-O-octadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-O-octadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA"}
{"X":39576,"RHEA_ID":47745,"DIRECTION":"LR","MASTER_ID":47744,"metacyc":"RXN-17007","compounds":"demethylphylloquinone + H(+) + NADPH => demethylphylloquinol + NADP(+)"}
{"X":39577,"RHEA_ID":37843,"compounds":"1-eicosanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-eicosanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39578,"RHEA_ID":37844,"compounds":"1-eicosanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-eicosanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39579,"RHEA_ID":37845,"compounds":"1-eicosanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-eicosanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA"}
{"X":39580,"RHEA_ID":47749,"DIRECTION":"LR","MASTER_ID":47748,"metacyc":"TRANS-RXN-214","compounds":"a ubiquinone + H(+) + n Na(+)(in) + NADH => a ubiquinol + n Na(+)(out) + NAD(+)"}
{"X":39581,"RHEA_ID":37847,"DIRECTION":"UN","MASTER_ID":37847,"ec":"1.14.13.181","compounds":"13-dihydrodaunorubicin + H(+) + NADPH + O2 = daunorubicin + 2 H2O + NADP(+)"}
{"X":39582,"RHEA_ID":37848,"DIRECTION":"LR","MASTER_ID":37847,"metacyc":"RXN-14830","compounds":"13-dihydrodaunorubicin + H(+) + NADPH + O2 => daunorubicin + 2 H2O + NADP(+)"}
{"X":39583,"RHEA_ID":37849,"compounds":"daunorubicin + 2 H2O + NADP(+) => 13-dihydrodaunorubicin + H(+) + NADPH + O2"}
{"X":39584,"RHEA_ID":57787,"compounds":"1,4-dinitrobenzene + NADH + O2 <=> 4-nitrocatechol + H(+) + NAD(+) + nitrite"}
{"X":39585,"RHEA_ID":47754,"compounds":"5-hydroxy-3-methyl-O-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine => 5-hydroxy-3-methyl-L-tyrosine + S-adenosyl-L-methionine"}
{"X":39586,"RHEA_ID":37852,"DIRECTION":"LR","MASTER_ID":37851,"metacyc":"RXN-14829","compounds":"13-deoxydaunorubicin + H(+) + NADPH + O2 => 13-dihydrodaunorubicin + H2O + NADP(+)"}
{"X":39587,"RHEA_ID":37853,"compounds":"13-dihydrodaunorubicin + H2O + NADP(+) => 13-deoxydaunorubicin + H(+) + NADPH + O2"}
{"X":39588,"RHEA_ID":57791,"compounds":"1,3-dinitrobenzene + NADH + O2 <=> 4-nitrocatechol + H(+) + NAD(+) + nitrite"}
{"X":39589,"RHEA_ID":47758,"compounds":"2'-O-methylguanosine(1370) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(1370) in 16S rRNA + S-adenosyl-L-methionine"}
{"X":39590,"RHEA_ID":37856,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + hexanoyl-CoA => 1-hexadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39591,"RHEA_ID":37857,"compounds":"1-hexadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexanoyl-CoA"}
{"X":39592,"RHEA_ID":47761,"compounds":"a uridine in 21S rRNA + S-adenosyl-L-methionine => a 2'-O-methyluridine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":39593,"RHEA_ID":37859,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + octanoyl-CoA = 1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39594,"RHEA_ID":37860,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + octanoyl-CoA => 1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39595,"RHEA_ID":37861,"compounds":"1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + octanoyl-CoA"}
{"X":39596,"RHEA_ID":47765,"compounds":"S-adenosyl-L-methionine + uridine(1369) in 16S rRNA => 2'-O-methyluridine(1369) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":39597,"RHEA_ID":37863,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + decanoyl-CoA = 1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39598,"RHEA_ID":37864,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + decanoyl-CoA => 1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39599,"RHEA_ID":37865,"compounds":"1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + decanoyl-CoA"}
{"X":39600,"RHEA_ID":47769,"compounds":"guanosine(2270) in 21S rRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine(2270) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":39601,"RHEA_ID":47770,"compounds":"2'-O-methylguanosine(2270) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(2270) in 21S rRNA + S-adenosyl-L-methionine"}
{"X":39602,"RHEA_ID":37868,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + tetradecanoyl-CoA => 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":39603,"RHEA_ID":37869,"compounds":"1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + tetradecanoyl-CoA"}
{"X":39604,"RHEA_ID":47773,"compounds":"a guanosine in 21S rRNA + S-adenosyl-L-methionine => a 2'-O-methylguanosine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":39605,"RHEA_ID":37871,"DIRECTION":"UN","MASTER_ID":37871,"ec":"1.14.13.182","compounds":"2-heptyl-4(1H)-quinolone + H(+) + NADH + O2 = 2-heptyl-3-hydroxy-4(1H)-quinolone + H2O + NAD(+)"}
{"X":39606,"RHEA_ID":37872,"DIRECTION":"LR","MASTER_ID":37871,"metacyc":"RXN-11849","compounds":"2-heptyl-4(1H)-quinolone + H(+) + NADH + O2 => 2-heptyl-3-hydroxy-4(1H)-quinolone + H2O + NAD(+)"}
{"X":39607,"RHEA_ID":37873,"compounds":"2-heptyl-3-hydroxy-4(1H)-quinolone + H2O + NAD(+) => 2-heptyl-4(1H)-quinolone + H(+) + NADH + O2"}
{"X":39608,"RHEA_ID":47777,"compounds":"guanosine(1145) in 16S rRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine(1145) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":39609,"RHEA_ID":37875,"DIRECTION":"UN","MASTER_ID":37875,"ec":"2.1.1.288","compounds":"aklanonate + S-adenosyl-L-methionine = methyl aklanonate + S-adenosyl-L-homocysteine"}
{"X":39610,"RHEA_ID":37876,"DIRECTION":"LR","MASTER_ID":37875,"metacyc":"RXN-14831","compounds":"aklanonate + S-adenosyl-L-methionine => methyl aklanonate + S-adenosyl-L-homocysteine"}
{"X":39611,"RHEA_ID":37877,"compounds":"methyl aklanonate + S-adenosyl-L-homocysteine => aklanonate + S-adenosyl-L-methionine"}
{"X":39612,"RHEA_ID":57815,"compounds":"1-chloro-2-nitrobenzene + NADH + O2 <=> 3-chlorocatechol + NAD(+) + nitrite"}
{"X":39613,"RHEA_ID":37879,"DIRECTION":"UN","MASTER_ID":37879,"ec":"5.5.1.23","compounds":"methyl aklanonate = aklaviketone"}
{"X":39614,"RHEA_ID":37880,"DIRECTION":"LR","MASTER_ID":37879,"metacyc":"RXN-14844","compounds":"methyl aklanonate => aklaviketone"}
{"X":39615,"RHEA_ID":37881,"compounds":"aklaviketone => methyl aklanonate"}
{"X":39616,"RHEA_ID":47785,"compounds":"cytidine(3782) in 28S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(3782) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":39617,"RHEA_ID":47786,"compounds":"5-methylcytidine(3782) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(3782) in 28S rRNA + S-adenosyl-L-methionine"}
{"X":39618,"RHEA_ID":37884,"compounds":"acetyl-CoA + oxalate => acetate + oxalyl-CoA"}
{"X":39619,"RHEA_ID":37885,"compounds":"acetate + oxalyl-CoA => acetyl-CoA + oxalate"}
{"X":39620,"RHEA_ID":57823,"compounds":"[phosphate](n) + ADP <=> [phosphate](n+1) + AMP"}
{"X":39621,"RHEA_ID":47790,"compounds":"a 5-methylcytidine in 28S rRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in 28S rRNA + S-adenosyl-L-methionine"}
{"X":39622,"RHEA_ID":37888,"compounds":"S-adenosyl-L-methionine + small RNA 3'-end nucleotide => H(+) + S-adenosyl-L-homocysteine + small RNA 3'-end 2'-O-methylnucleotide"}
{"X":39623,"RHEA_ID":37889,"compounds":"H(+) + S-adenosyl-L-homocysteine + small RNA 3'-end 2'-O-methylnucleotide => S-adenosyl-L-methionine + small RNA 3'-end nucleotide"}
{"X":39624,"RHEA_ID":47793,"compounds":"cytidine(4447) in 28S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(4447) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":39625,"RHEA_ID":47794,"compounds":"5-methylcytidine(4447) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(4447) in 28S rRNA + S-adenosyl-L-methionine"}
{"X":39626,"RHEA_ID":37892,"DIRECTION":"LR","MASTER_ID":37891,"metacyc":"RXN-14703","compounds":"aclacinomycin T + H2O => 15-demethylaclacinomycin T + methanol"}
{"X":39627,"RHEA_ID":37893,"compounds":"15-demethylaclacinomycin T + methanol => aclacinomycin T + H2O"}
{"X":39628,"RHEA_ID":47797,"compounds":"an aralkylamine + H2O + 2 oxidized [azurin] => an aromatic aldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin]"}
{"X":39629,"RHEA_ID":47798,"compounds":"an aromatic aldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin] => an aralkylamine + H2O + 2 oxidized [azurin]"}
{"X":39630,"RHEA_ID":37896,"DIRECTION":"LR","MASTER_ID":37895,"metacyc":"RXN-14633","compounds":"H2O + protodioscin => 26-deglucoprotodioscin + D-glucose"}
{"X":39631,"RHEA_ID":37897,"compounds":"26-deglucoprotodioscin + D-glucose => H2O + protodioscin"}
{"X":39632,"RHEA_ID":47801,"compounds":"4-methylsulfanyl-2-oxobutanoate + an aromatic L-alpha-amino acid => an aromatic oxo-acid + L-methionine"}
{"X":39633,"RHEA_ID":47802,"compounds":"an aromatic oxo-acid + L-methionine => 4-methylsulfanyl-2-oxobutanoate + an aromatic L-alpha-amino acid"}
{"X":39634,"RHEA_ID":37900,"DIRECTION":"LR","MASTER_ID":37899,"metacyc":"RXN-14538","compounds":"2-oxoglutarate + 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + O2 => 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + CO2 + succinate"}
{"X":39635,"RHEA_ID":37901,"compounds":"7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + CO2 + succinate => 2-oxoglutarate + 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + O2"}
{"X":39636,"RHEA_ID":57839,"compounds":"H2O + O2 + thermospermine <=> 3-aminopropanal + H2O2 + spermidine"}
{"X":39637,"RHEA_ID":47806,"compounds":"epothilone A + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => epothilone C + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":39638,"RHEA_ID":37904,"DIRECTION":"LR","MASTER_ID":37903,"metacyc":"RXN-14927","compounds":"6-hydroxytryprostatin B + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + tryprostatin A"}
{"X":39639,"RHEA_ID":37905,"compounds":"H(+) + S-adenosyl-L-homocysteine + tryprostatin A => 6-hydroxytryprostatin B + S-adenosyl-L-methionine"}
{"X":39640,"RHEA_ID":57842,"compounds":"1D-myo-inositol 1-phosphate + phosphate => 1D-myo-inositol 1,3-bisphosphate + H2O"}
{"X":39641,"RHEA_ID":47810,"compounds":"epothilone B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => epothilone D + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":39642,"RHEA_ID":37908,"DIRECTION":"LR","MASTER_ID":37907,"metacyc":"RXN-14923","compounds":"(9Z)-octadecenoate + O2 => (8E,10S)-10-hydroperoxy-octadeca-8-enoate"}
{"X":39643,"RHEA_ID":37909,"compounds":"(8E,10S)-10-hydroperoxy-octadeca-8-enoate => (9Z)-octadecenoate + O2"}
{"X":39644,"RHEA_ID":57846,"compounds":"H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sideretin (reduced form) => fraxetin + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":39645,"RHEA_ID":47814,"compounds":"9-ribosyl-trans-zeatin 5'-phosphate + H2O + NADP(+) => H(+) + N(6)-(dimethylallyl)adenosine 5'-phosphate + NADPH + O2"}
{"X":39646,"RHEA_ID":37912,"compounds":"(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoA"}
{"X":39647,"RHEA_ID":37913,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoA => (9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol"}
{"X":39648,"RHEA_ID":37914,"compounds":"(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol <=> 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoA"}
{"X":39649,"RHEA_ID":47818,"compounds":"9-ribosyl-trans-zeatin 5'-diphosphate + H2O + NADP(+) => H(+) + N(6)-(dimethylallyl)adenosine 5'-diphosphate + NADPH + O2"}
{"X":39650,"RHEA_ID":37916,"compounds":"(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-glycerol + CoA"}
{"X":39651,"RHEA_ID":37917,"compounds":"1,2-di-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol"}
{"X":39652,"RHEA_ID":37918,"compounds":"(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol <=> 1,2-di-(9Z-octadecenoyl)-glycerol + CoA"}
{"X":39653,"RHEA_ID":47822,"compounds":"9-ribosyl-trans-zeatin 5'-triphosphate + H2O + NADP(+) => H(+) + N(6)-(dimethylallyl)adenosine 5'-triphosphate + NADPH + O2"}
{"X":39654,"RHEA_ID":37920,"DIRECTION":"LR","MASTER_ID":37919,"metacyc":"RXN-14925","compounds":"(9Z,12Z)-octadecadienoate + O2 => (8E,10S,12Z)-10-hydroperoxyoctadeca-8,12-dienoate"}
{"X":39655,"RHEA_ID":37921,"compounds":"(8E,10S,12Z)-10-hydroperoxyoctadeca-8,12-dienoate => (9Z,12Z)-octadecadienoate + O2"}
{"X":39656,"RHEA_ID":57858,"compounds":"(E)-6-hydroxyferuloyl-CoA + CO2 + succinate => (E)-feruloyl-CoA + 2-oxoglutarate + O2"}
{"X":39657,"RHEA_ID":37923,"DIRECTION":"UN","MASTER_ID":37923,"ec":"1.13.11.77","compounds":"(9Z,12Z,15Z)-octadecatrienoate + O2 = (8E,10S,12Z,15Z)-10-hydroperoxyoctadeca-8,12,15-trienoate"}
{"X":39658,"RHEA_ID":47827,"compounds":"H(+) + malonyl-[ACP] + octadecanoyl-[ACP] <=> 3-oxoeicosanoyl-[ACP] + CO2 + holo-[ACP]"}
{"X":39659,"RHEA_ID":37925,"compounds":"(8E,10S,12Z,15Z)-10-hydroperoxyoctadeca-8,12,15-trienoate => (9Z,12Z,15Z)-octadecatrienoate + O2"}
{"X":39660,"RHEA_ID":57862,"compounds":"CoA + scopoletin => (E)-6-hydroxyferuloyl-CoA"}
{"X":39661,"RHEA_ID":37927,"DIRECTION":"UN","MASTER_ID":37927,"ec":"4.2.1.152","compounds":"(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate = 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O"}
{"X":39662,"RHEA_ID":47831,"compounds":"ganglioside GT1b + H2O <=> ganglioside GD1b + N-acetylneuraminate"}
{"X":39663,"RHEA_ID":37929,"compounds":"8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O => (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate"}
{"X":39664,"RHEA_ID":47833,"compounds":"ganglioside GD1a + H2O => ganglioside GM1a + N-acetylneuraminate"}
{"X":39665,"RHEA_ID":37931,"DIRECTION":"UN","MASTER_ID":37931,"ec":"5.4.4.7","compounds":"(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate = (10R)-hydroxy-(8S,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate"}
{"X":39666,"RHEA_ID":47835,"compounds":"ganglioside GD1a + H2O <=> ganglioside GM1a + N-acetylneuraminate"}
{"X":39667,"RHEA_ID":37933,"compounds":"(10R)-hydroxy-(8S,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate => (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate"}
{"X":39668,"RHEA_ID":47837,"DIRECTION":"LR","MASTER_ID":47836,"metacyc":"RXN-15944","compounds":"[5-(aminomethyl)-3-furyl]methyl phosphate + ATP => [5-(aminomethyl)furan-3-yl]methyl diphosphate + ADP"}
{"X":39669,"RHEA_ID":37935,"DIRECTION":"UN","MASTER_ID":37935,"ec":"4.2.1.152","compounds":"(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate = 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O"}
{"X":39670,"RHEA_ID":57872,"compounds":"(E)-2,4-dihydroxycinnamoyl-CoA = CoA + umbelliferone"}
{"X":39671,"RHEA_ID":37937,"compounds":"8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O => (8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate"}
{"X":39672,"RHEA_ID":47841,"DIRECTION":"LR","MASTER_ID":47840,"metacyc":"RXN-15945","compounds":"[5-(aminomethyl)furan-3-yl]methyl diphosphate + gamma-L-glutamyltyramine => (4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine + diphosphate"}
{"X":39673,"RHEA_ID":37939,"DIRECTION":"UN","MASTER_ID":37939,"ec":"5.4.4.7","compounds":"(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = (8R)-hydroxy-(11R,12R)-epoxy-(5Z,9E,14Z)-eicosatrienoate"}
{"X":39674,"RHEA_ID":37940,"compounds":"(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => (8R)-hydroxy-(11R,12R)-epoxy-(5Z,9E,14Z)-eicosatrienoate"}
{"X":39675,"RHEA_ID":37941,"compounds":"(8R)-hydroxy-(11R,12R)-epoxy-(5Z,9E,14Z)-eicosatrienoate => (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate"}
{"X":39676,"RHEA_ID":47845,"DIRECTION":"LR","MASTER_ID":47844,"ecocyc":"RXN-12611","metacyc":"RXN-12611","compounds":"2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) => CO2 + diphosphate + thiamine phosphate"}
{"X":39677,"RHEA_ID":37943,"DIRECTION":"UN","MASTER_ID":37943,"ec":"4.2.1.152","compounds":"(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O"}
{"X":39678,"RHEA_ID":57880,"DIRECTION":"UN","MASTER_ID":57880,"ec":"2.4.2.61","compounds":"3-O-[(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-threonyl-[protein] + UDP-alpha-D-xylose = 3-O-[beta-D-xylosyl-(1->4)-(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-threonyl-[protein] + H(+) + UDP"}
{"X":39679,"RHEA_ID":37945,"compounds":"12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O => (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate"}
{"X":39680,"RHEA_ID":47849,"DIRECTION":"LR","MASTER_ID":47848,"metacyc":"RXN-12610","compounds":"2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) => CO2 + diphosphate + thiamine phosphate"}
{"X":39681,"RHEA_ID":37947,"DIRECTION":"UN","MASTER_ID":37947,"ec":"4.2.1.152","compounds":"(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O"}
{"X":39682,"RHEA_ID":57884,"compounds":"diphosphate + H2O + Na(+)(in) = H(+) + Na(+)(out) + 2 phosphate"}
{"X":39683,"RHEA_ID":37949,"compounds":"12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O => (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate"}
{"X":39684,"RHEA_ID":47853,"compounds":"a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + H2O => a neolactoside nLc4Cer(d18:1(4E)) + N-acetylneuraminate"}
{"X":39685,"RHEA_ID":37951,"DIRECTION":"UN","MASTER_ID":37951,"ec":"5.4.4.7","compounds":"(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = (10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate"}
{"X":39686,"RHEA_ID":47855,"compounds":"a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + H2O <=> a neolactoside nLc4Cer(d18:1(4E)) + N-acetylneuraminate"}
{"X":39687,"RHEA_ID":37953,"compounds":"(10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate => (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate"}
{"X":39688,"RHEA_ID":47857,"compounds":"ganglioside GD1a (18:1(4E)) + H2O => ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate"}
{"X":39689,"RHEA_ID":37955,"DIRECTION":"UN","MASTER_ID":37955,"ec":"5.4.4.7","compounds":"(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = (8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate"}
{"X":39690,"RHEA_ID":37956,"compounds":"(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => (8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate"}
{"X":39691,"RHEA_ID":37957,"compounds":"(8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate => (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate"}
{"X":39692,"RHEA_ID":37958,"DIRECTION":"BI","MASTER_ID":37955,"metacyc":"RXN-14948","compounds":"(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate <=> (8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate"}
{"X":39693,"RHEA_ID":37959,"DIRECTION":"UN","MASTER_ID":37959,"ec":"5.4.4.7","compounds":"(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = (13R)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate"}
{"X":39694,"RHEA_ID":37960,"compounds":"(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => (13R)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate"}
{"X":39695,"RHEA_ID":37961,"compounds":"(13R)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate"}
{"X":39696,"RHEA_ID":37962,"compounds":"(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate <=> (13R)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate"}
{"X":39697,"RHEA_ID":37963,"DIRECTION":"UN","MASTER_ID":37963,"ec":"1.1.1.21","compounds":"galactitol + NAD(+) = D-galactose + H(+) + NADH"}
{"X":39698,"RHEA_ID":47867,"compounds":"1,2,3-trioctanoylglycerol + H2O <=> dioctanoylglycerol + H(+) + octanoate"}
{"X":39699,"RHEA_ID":37965,"compounds":"D-galactose + H(+) + NADH => galactitol + NAD(+)"}
{"X":39700,"RHEA_ID":57902,"compounds":"adenosine in U6 snRNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + N(6)-methyladenosine in U6 snRNA + O2"}
{"X":39701,"RHEA_ID":37967,"DIRECTION":"UN","MASTER_ID":37967,"ec":"1.1.1.21","compounds":"galactitol + NADP(+) = D-galactose + H(+) + NADPH"}
{"X":39702,"RHEA_ID":47871,"compounds":"di-(9Z)-octadecenoylglycerol + H2O <=> (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)"}
{"X":39703,"RHEA_ID":37969,"compounds":"D-galactose + H(+) + NADPH => galactitol + NADP(+)"}
{"X":39704,"RHEA_ID":47873,"compounds":"ganglioside GM1a + H2O => ganglioside GA1 + N-acetylneuraminate"}
{"X":39705,"RHEA_ID":37971,"DIRECTION":"UN","MASTER_ID":37971,"ec":"1.14.19.n4","compounds":"H(+) + NADPH + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + 2 H2O + NADP(+)"}
{"X":39706,"RHEA_ID":47875,"compounds":"ganglioside GM1a + H2O <=> ganglioside GA1 + N-acetylneuraminate"}
{"X":39707,"RHEA_ID":37973,"compounds":"(9Z)-octadecenoyl-CoA + 2 H2O + NADP(+) => H(+) + NADPH + O2 + octadecanoyl-CoA"}
{"X":39708,"RHEA_ID":47877,"compounds":"ganglioside GD1b + H2O => ganglioside GM1a + N-acetylneuraminate"}
{"X":39709,"RHEA_ID":37975,"DIRECTION":"UN","MASTER_ID":37975,"ec":"2.5.1.115","compounds":"H(+) + homogentisate + phytyl diphosphate = 2-methyl-6-phytyl-1,4-benzene-1,4-diol + CO2 + diphosphate"}
{"X":39710,"RHEA_ID":47879,"compounds":"ganglioside GD1b + H2O <=> ganglioside GM1a + N-acetylneuraminate"}
{"X":39711,"RHEA_ID":37977,"compounds":"2-methyl-6-phytyl-1,4-benzene-1,4-diol + CO2 + diphosphate => H(+) + homogentisate + phytyl diphosphate"}
{"X":39712,"RHEA_ID":57914,"compounds":"H(+) + L-glutaminyl-tRNA(Gln) + phosphate => 5-phosphooxy-L-glutamyl-tRNA(Gln) + NH4(+)"}
{"X":39713,"RHEA_ID":37979,"DIRECTION":"UN","MASTER_ID":37979,"ec":"2.1.1.295","compounds":"2-methyl-6-phytyl-1,4-benzene-1,4-diol + S-adenosyl-L-methionine = 2,3-dimethyl-6-phytylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine"}
{"X":39714,"RHEA_ID":47883,"compounds":"dioctanoylglycerol + H2O <=> H(+) + octanoate + octanoylglycerol"}
{"X":39715,"RHEA_ID":37981,"compounds":"2,3-dimethyl-6-phytylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine => 2-methyl-6-phytyl-1,4-benzene-1,4-diol + S-adenosyl-L-methionine"}
{"X":39716,"RHEA_ID":47885,"compounds":"CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine => CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine"}
{"X":39717,"RHEA_ID":37983,"DIRECTION":"UN","MASTER_ID":37983,"ec":"5.5.1.24","compounds":"gamma-tocopherol = 2,3-dimethyl-6-phytylbenzene-1,4-diol"}
{"X":39718,"RHEA_ID":37984,"compounds":"gamma-tocopherol => 2,3-dimethyl-6-phytylbenzene-1,4-diol"}
{"X":39719,"RHEA_ID":37985,"DIRECTION":"RL","MASTER_ID":37983,"metacyc":"RXN-2543","compounds":"2,3-dimethyl-6-phytylbenzene-1,4-diol => gamma-tocopherol"}
{"X":39720,"RHEA_ID":57922,"compounds":"H(+) + L-asparaginyl-tRNA(Asn) + phosphate => 4-phosphooxy-L-aspartyl-tRNA(Asn) + NH4(+)"}
{"X":39721,"RHEA_ID":37987,"DIRECTION":"UN","MASTER_ID":37987,"ec":"5.5.1.24","compounds":"delta-tocopherol = 2-methyl-6-phytyl-1,4-benzene-1,4-diol"}
{"X":39722,"RHEA_ID":47891,"compounds":"GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine <=> GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine"}
{"X":39723,"RHEA_ID":37989,"DIRECTION":"RL","MASTER_ID":37987,"metacyc":"RXN-2561","compounds":"2-methyl-6-phytyl-1,4-benzene-1,4-diol => delta-tocopherol"}
{"X":39724,"RHEA_ID":57926,"compounds":"diphosphate + premutilin => H2O + mutildienyl diphosphate"}
{"X":39725,"RHEA_ID":37991,"DIRECTION":"UN","MASTER_ID":37991,"ec":"2.1.1.95","compounds":"delta-tocopherol + S-adenosyl-L-methionine = beta-tocopherol + H(+) + S-adenosyl-L-homocysteine"}
{"X":39726,"RHEA_ID":47895,"compounds":"GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine <=> GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->6)-N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine"}
{"X":39727,"RHEA_ID":37993,"compounds":"beta-tocopherol + H(+) + S-adenosyl-L-homocysteine => delta-tocopherol + S-adenosyl-L-methionine"}
{"X":39728,"RHEA_ID":47897,"DIRECTION":"LR","MASTER_ID":47896,"metacyc":"RXN-17096","compounds":"6-sulfo-D-quinovose + NAD(+) => 6-deoxy-6-sulfo-D-glucono-1,5-lactone + H(+) + NADH"}
{"X":39729,"RHEA_ID":37995,"DIRECTION":"UN","MASTER_ID":37995,"ec":"2.5.1.117","compounds":"all-trans-nonaprenyl diphosphate + H(+) + homogentisate = 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2 + diphosphate"}
{"X":39730,"RHEA_ID":57932,"compounds":"beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + NH4(+) = beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + H(+) + phosphate"}
{"X":39731,"RHEA_ID":37997,"compounds":"2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2 + diphosphate => all-trans-nonaprenyl diphosphate + H(+) + homogentisate"}
{"X":39732,"RHEA_ID":57934,"compounds":"beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + H(+) + phosphate => beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + NH4(+)"}
{"X":39733,"RHEA_ID":37999,"DIRECTION":"UN","MASTER_ID":37999,"ec":"2.1.1.295","compounds":"2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + S-adenosyl-L-methionine = H(+) + plastoquinol-9 + S-adenosyl-L-homocysteine"}
{"X":39734,"RHEA_ID":38000,"DIRECTION":"LR","MASTER_ID":37999,"metacyc":"RXN-2762","compounds":"2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + S-adenosyl-L-methionine => H(+) + plastoquinol-9 + S-adenosyl-L-homocysteine"}
{"X":39735,"RHEA_ID":38001,"compounds":"H(+) + plastoquinol-9 + S-adenosyl-L-homocysteine => 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + S-adenosyl-L-methionine"}
{"X":39736,"RHEA_ID":57938,"compounds":"5-pyridoxate + 2 H(+) + NADH => H2O + isopyridoxal + NAD(+)"}
{"X":39737,"RHEA_ID":38003,"DIRECTION":"UN","MASTER_ID":38003,"ec":"2.5.1.116","compounds":"all-trans-geranylgeranyl diphosphate + H(+) + homogentisate = 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2 + diphosphate"}
{"X":39738,"RHEA_ID":38004,"DIRECTION":"LR","MASTER_ID":38003,"metacyc":"RXN-14929","compounds":"all-trans-geranylgeranyl diphosphate + H(+) + homogentisate => 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2 + diphosphate"}
{"X":39739,"RHEA_ID":38005,"compounds":"6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2 + diphosphate => all-trans-geranylgeranyl diphosphate + H(+) + homogentisate"}
{"X":39740,"RHEA_ID":47909,"DIRECTION":"LR","MASTER_ID":47908,"metacyc":"RXN-17095","compounds":"6-deoxy-6-sulfo-D-glucono-1,5-lactone + H2O => 6-deoxy-6-sulfo-D-gluconate + H(+)"}
{"X":39741,"RHEA_ID":38007,"DIRECTION":"UN","MASTER_ID":38007,"ec":"2.1.1.295","compounds":"6-geranylgeranyl-2-methylbenzene-1,4-diol + S-adenosyl-L-methionine = 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine"}
{"X":39742,"RHEA_ID":38008,"DIRECTION":"LR","MASTER_ID":38007,"metacyc":"RXN-14917","compounds":"6-geranylgeranyl-2-methylbenzene-1,4-diol + S-adenosyl-L-methionine => 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine"}
{"X":39743,"RHEA_ID":38009,"compounds":"6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine => 6-geranylgeranyl-2-methylbenzene-1,4-diol + S-adenosyl-L-methionine"}
{"X":39744,"RHEA_ID":57946,"compounds":"CO2 + 2 H2O + heme b => H(+) + H2O2 + harderoheme III"}
{"X":39745,"RHEA_ID":38011,"DIRECTION":"UN","MASTER_ID":38011,"ec":"3.1.1.14","compounds":"chlorophyll a + H2O = chlorophyllide a + H(+) + phytol"}
{"X":39746,"RHEA_ID":57948,"DIRECTION":"UN","MASTER_ID":57948,"ec":"1.14.13.243","compounds":"2-hydroxytoluene + H(+) + NADH + O2 = 3-methylcatechol + H2O + NAD(+)"}
{"X":39747,"RHEA_ID":38013,"compounds":"chlorophyllide a + H(+) + phytol => chlorophyll a + H2O"}
{"X":39748,"RHEA_ID":57950,"compounds":"3-methylcatechol + H2O + NAD(+) => 2-hydroxytoluene + H(+) + NADH + O2"}
{"X":39749,"RHEA_ID":38015,"DIRECTION":"UN","MASTER_ID":38015,"ec":"5.5.1.24","compounds":"delta-tocotrienol = 6-geranylgeranyl-2-methylbenzene-1,4-diol"}
{"X":39750,"RHEA_ID":38016,"compounds":"delta-tocotrienol => 6-geranylgeranyl-2-methylbenzene-1,4-diol"}
{"X":39751,"RHEA_ID":38017,"DIRECTION":"RL","MASTER_ID":38015,"metacyc":"RXN-14921","compounds":"6-geranylgeranyl-2-methylbenzene-1,4-diol => delta-tocotrienol"}
{"X":39752,"RHEA_ID":57954,"compounds":"catechol + H2O + NAD(+) => H(+) + NADH + O2 + phenol"}
{"X":39753,"RHEA_ID":38019,"compounds":"(9Z)-octadecenoyl-CoA + 1-decanoylglycerol = 1-decanoyl-2-(9Z-octadecenoyl)-glycerol + CoA"}
{"X":39754,"RHEA_ID":38020,"compounds":"(9Z)-octadecenoyl-CoA + 1-decanoylglycerol => 1-decanoyl-2-(9Z-octadecenoyl)-glycerol + CoA"}
{"X":39755,"RHEA_ID":38021,"compounds":"1-decanoyl-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-decanoylglycerol"}
{"X":39756,"RHEA_ID":57958,"compounds":"dimethyl sulfone + H2O + NAD(+) => dimethyl sulfoxide + H(+) + NADH + O2"}
{"X":39757,"RHEA_ID":38023,"DIRECTION":"UN","MASTER_ID":38023,"ec":"5.5.1.24","compounds":"gamma-tocotrienol = 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol"}
{"X":39758,"RHEA_ID":38024,"compounds":"gamma-tocotrienol => 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol"}
{"X":39759,"RHEA_ID":38025,"DIRECTION":"RL","MASTER_ID":38023,"metacyc":"RXN-14922","compounds":"6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol => gamma-tocotrienol"}
{"X":39760,"RHEA_ID":57962,"compounds":"dimethyl sulfoxide + H2O + NAD(+) => dimethyl sulfide + H(+) + NADH + O2"}
{"X":39761,"RHEA_ID":38027,"DIRECTION":"UN","MASTER_ID":38027,"ec":"2.8.3.23","metacyc":"RXN-16745","compounds":"(E)-caffeate + hydrocaffeoyl-CoA = (E)-caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)propanoate"}
{"X":39762,"RHEA_ID":38028,"compounds":"(E)-caffeate + hydrocaffeoyl-CoA => (E)-caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)propanoate"}
{"X":39763,"RHEA_ID":38029,"compounds":"(E)-caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)propanoate => (E)-caffeate + hydrocaffeoyl-CoA"}
{"X":39764,"RHEA_ID":57966,"compounds":"8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":39765,"RHEA_ID":38031,"compounds":"(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+) = (2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate + CO2"}
{"X":39766,"RHEA_ID":38032,"DIRECTION":"LR","MASTER_ID":38031,"metacyc":"CARBOXY-OXOHEPT-ENEDIOATE-DECARBOXY-RXN","compounds":"(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+) => (2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate + CO2"}
{"X":39767,"RHEA_ID":38033,"compounds":"(2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate + CO2 => (3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+)"}
{"X":39768,"RHEA_ID":57970,"compounds":"8-epi-inunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":39769,"RHEA_ID":38035,"compounds":"(2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate = (4Z)-2-oxohept-4-enedioate"}
{"X":39770,"RHEA_ID":38036,"DIRECTION":"LR","MASTER_ID":38035,"metacyc":"RXN1K-87","compounds":"(2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate => (4Z)-2-oxohept-4-enedioate"}
{"X":39771,"RHEA_ID":38037,"compounds":"(4Z)-2-oxohept-4-enedioate => (2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate"}
{"X":39772,"RHEA_ID":47941,"compounds":"ganglioside GM2 (d18:1(4E)) + H2O => ganglioside GM3 (d18:1(4E)) + N-acetyl-beta-D-galactosamine"}
{"X":39773,"RHEA_ID":38039,"DIRECTION":"UN","MASTER_ID":38039,"ec":"1.14.19.12","compounds":"(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a (5Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 H2O"}
{"X":39774,"RHEA_ID":38040,"DIRECTION":"LR","MASTER_ID":38039,"metacyc":"RXN-13857","compounds":"(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a (5Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 H2O"}
{"X":39775,"RHEA_ID":38041,"compounds":"2 [Fe(III)-cytochrome b5] + a (5Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 H2O => (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}
{"X":39776,"RHEA_ID":57978,"compounds":"(20S)-ginsenoside C-K + H(+) + UDP => (20S)-protopanaxadiol + UDP-alpha-D-glucose"}
{"X":39777,"RHEA_ID":38043,"DIRECTION":"UN","MASTER_ID":38043,"ec":"1.14.19.11","compounds":"2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (4Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":39778,"RHEA_ID":38044,"DIRECTION":"LR","MASTER_ID":38043,"metacyc":"RXN-8390","compounds":"2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (4Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":39779,"RHEA_ID":38045,"compounds":"(4Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":39780,"RHEA_ID":47949,"DIRECTION":"LR","MASTER_ID":47948,"metacyc":"RXNQT-4191","compounds":"H2O + thiamine phosphate => phosphate + thiamine"}
{"X":39781,"RHEA_ID":38047,"DIRECTION":"UN","MASTER_ID":38047,"ec":"1.14.19.34","compounds":"2 [Fe(II)-cytochrome b5] + a (9Z)-octadecenoyl-containing glycerolipid + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a (9Z,12E)-octadecadienoyl-containing glycerolipid + 2 H2O"}
{"X":39782,"RHEA_ID":38048,"DIRECTION":"LR","MASTER_ID":38047,"metacyc":"RXN-8392","compounds":"2 [Fe(II)-cytochrome b5] + a (9Z)-octadecenoyl-containing glycerolipid + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a (9Z,12E)-octadecadienoyl-containing glycerolipid + 2 H2O"}
{"X":39783,"RHEA_ID":38049,"compounds":"2 [Fe(III)-cytochrome b5] + a (9Z,12E)-octadecadienoyl-containing glycerolipid + 2 H2O => 2 [Fe(II)-cytochrome b5] + a (9Z)-octadecenoyl-containing glycerolipid + 2 H(+) + O2"}
{"X":39784,"RHEA_ID":47953,"compounds":"[prokaryotic ubiquitin-like protein]-C-terminal-L-glutamine + H2O => [prokaryotic ubiquitin-like protein]-C-terminal-L-glutamate + NH4(+)"}
{"X":39785,"RHEA_ID":38051,"compounds":"2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA = 1-butyryl-2-(9Z)-octadecenoyl-sn-glycerol + CoA"}
{"X":39786,"RHEA_ID":38052,"compounds":"2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA => 1-butyryl-2-(9Z)-octadecenoyl-sn-glycerol + CoA"}
{"X":39787,"RHEA_ID":38053,"compounds":"1-butyryl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA"}
{"X":39788,"RHEA_ID":57990,"compounds":"(20S)-ginsenoside F2 + H(+) + UDP => (20S)-ginsenoside Rh2 + UDP-alpha-D-glucose"}
{"X":39789,"RHEA_ID":38055,"DIRECTION":"UN","MASTER_ID":38055,"ec":"2.7.1.182","compounds":"CTP + phytol = CDP + H(+) + phytyl phosphate"}
{"X":39790,"RHEA_ID":38056,"DIRECTION":"LR","MASTER_ID":38055,"metacyc":"RXN-7683","compounds":"CTP + phytol => CDP + H(+) + phytyl phosphate"}
{"X":39791,"RHEA_ID":38057,"compounds":"CDP + H(+) + phytyl phosphate => CTP + phytol"}
{"X":39792,"RHEA_ID":51336,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = 8-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate"}
{"X":39793,"RHEA_ID":38059,"compounds":"2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA = 1-octanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA"}
{"X":39794,"RHEA_ID":38060,"compounds":"2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA => 1-octanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA"}
{"X":39795,"RHEA_ID":38061,"compounds":"1-octanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA"}
{"X":39796,"RHEA_ID":57998,"compounds":"(20S)-ginsenoside Rh2 + H(+) + UDP => (20S)-protopanaxadiol + UDP-alpha-D-glucose"}
{"X":39797,"RHEA_ID":38063,"compounds":"2-(9Z-octadecenoyl)-glycerol + dodecanoyl-CoA = 1-dodecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA"}
{"X":39798,"RHEA_ID":38064,"compounds":"2-(9Z-octadecenoyl)-glycerol + dodecanoyl-CoA => 1-dodecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA"}
{"X":39799,"RHEA_ID":38065,"compounds":"1-dodecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + dodecanoyl-CoA"}
{"X":39800,"RHEA_ID":58002,"compounds":"(20S)-ginsenoside Rg3 + H(+) + UDP => (20S)-ginsenoside Rh2 + UDP-alpha-D-glucose"}
{"X":39801,"RHEA_ID":38067,"compounds":"2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA = 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA"}
{"X":39802,"RHEA_ID":38068,"compounds":"2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA => 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA"}
{"X":39803,"RHEA_ID":38069,"compounds":"1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA"}
{"X":39804,"RHEA_ID":58006,"compounds":"(20S)-ginsenoside Rd + H(+) + UDP => (20S)-ginsenoside F2 + UDP-alpha-D-glucose"}
{"X":39805,"RHEA_ID":38071,"compounds":"2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA"}
{"X":39806,"RHEA_ID":38072,"compounds":"2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA"}
{"X":39807,"RHEA_ID":38073,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA"}
{"X":39808,"RHEA_ID":51352,"compounds":"H2O + N-(9Z-octadecenoyl)-L-serine = (9Z)-octadecenoate + L-serine"}
{"X":39809,"RHEA_ID":38075,"compounds":"2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA"}
{"X":39810,"RHEA_ID":38076,"compounds":"2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA"}
{"X":39811,"RHEA_ID":38077,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA"}
{"X":39812,"RHEA_ID":58013,"compounds":"cyclic tetraadenylate => 2 5'-hydroxy-diadenylate 2',3'-cylic phosphate"}
{"X":39813,"RHEA_ID":38079,"compounds":"2-(9Z-octadecenoyl)-glycerol + eicosanoyl-CoA = 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA"}
{"X":39814,"RHEA_ID":38080,"compounds":"2-(9Z-octadecenoyl)-glycerol + eicosanoyl-CoA => 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA"}
{"X":39815,"RHEA_ID":38081,"compounds":"1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + eicosanoyl-CoA"}
{"X":39816,"RHEA_ID":58017,"DIRECTION":"LR","MASTER_ID":58016,"metacyc":"RXN-20052","compounds":"8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":39817,"RHEA_ID":38083,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA"}
{"X":39818,"RHEA_ID":38084,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 2-(9Z-octadecenoyl)-glycerol => 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA"}
{"X":39819,"RHEA_ID":38085,"compounds":"1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => (9Z,12Z)-octadecadienoyl-CoA + 2-(9Z-octadecenoyl)-glycerol"}
{"X":39820,"RHEA_ID":38086,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 2-(9Z-octadecenoyl)-glycerol <=> 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA"}
{"X":39821,"RHEA_ID":38087,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA"}
{"X":39822,"RHEA_ID":47989,"DIRECTION":"LR","MASTER_ID":47988,"metacyc":"RXN-16964","compounds":"2-dehydro-3-deoxy-L-galactonate + NAD(+) => 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH"}
{"X":39823,"RHEA_ID":38089,"compounds":"1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol"}
{"X":39824,"RHEA_ID":58025,"DIRECTION":"LR","MASTER_ID":58024,"metacyc":"RXN-19701","compounds":"oleanolate + UDP-alpha-D-glucose => H(+) + oleanolate 3-O-beta-D-glucoside + UDP"}
{"X":39825,"RHEA_ID":38091,"DIRECTION":"UN","MASTER_ID":38091,"ec":"2.1.1.95","compounds":"delta-tocotrienol + S-adenosyl-L-methionine = beta-tocotrienol + H(+) + S-adenosyl-L-homocysteine"}
{"X":39826,"RHEA_ID":47993,"compounds":"H(+)(in) + NAD(+) + NADPH => H(+)(out) + NADH + NADP(+)"}
{"X":39827,"RHEA_ID":38093,"compounds":"beta-tocotrienol + H(+) + S-adenosyl-L-homocysteine => delta-tocotrienol + S-adenosyl-L-methionine"}
{"X":39828,"RHEA_ID":47995,"compounds":"H(+)(in) + NAD(+) + NADPH <=> H(+)(out) + NADH + NADP(+)"}
{"X":39829,"RHEA_ID":38095,"DIRECTION":"UN","MASTER_ID":38095,"ec":"2.1.1.95","compounds":"gamma-tocotrienol + S-adenosyl-L-methionine = alpha-tocotrienol + H(+) + S-adenosyl-L-homocysteine"}
{"X":39830,"RHEA_ID":47997,"compounds":"1,6-dihydro-beta-NAD + H(+) + O2 => H2O2 + NAD(+)"}
{"X":39831,"RHEA_ID":38097,"compounds":"alpha-tocotrienol + H(+) + S-adenosyl-L-homocysteine => gamma-tocotrienol + S-adenosyl-L-methionine"}
{"X":39832,"RHEA_ID":38099,"compounds":"a ribonucleoside 5'-triphosphate + phytyl phosphate = a ribonucleoside 5'-diphosphate + phytyl diphosphate"}
{"X":39833,"RHEA_ID":48001,"compounds":"1,6-dihydro-beta-NADP + H(+) + O2 => H2O2 + NADP(+)"}
{"X":39834,"RHEA_ID":38101,"compounds":"a ribonucleoside 5'-diphosphate + phytyl diphosphate => a ribonucleoside 5'-triphosphate + phytyl phosphate"}
{"X":39835,"RHEA_ID":38102,"compounds":"a ribonucleoside 5'-triphosphate + phytyl phosphate <=> a ribonucleoside 5'-diphosphate + phytyl diphosphate"}
{"X":39836,"RHEA_ID":48004,"DIRECTION":"UN","MASTER_ID":48004,"ec":"1.11.1.14","compounds":"1-(3,4-dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 = 3,4-dimethoxybenzaldehyde + glycolaldehyde + guaiacol + H2O"}
{"X":39837,"RHEA_ID":48005,"DIRECTION":"LR","MASTER_ID":48004,"metacyc":"RXN-17138","compounds":"1-(3,4-dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 => 3,4-dimethoxybenzaldehyde + glycolaldehyde + guaiacol + H2O"}
{"X":39838,"RHEA_ID":38105,"compounds":"2-dehydro-3-deoxy-L-galactonate + H2O => L-galactonate"}
{"X":39839,"RHEA_ID":58041,"compounds":"1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + H2O => (9Z,12Z,15Z)-octadecatrienoate + glycerol + H(+)"}
{"X":39840,"RHEA_ID":48008,"DIRECTION":"UN","MASTER_ID":48008,"ec":"1.14.13.209","compounds":"2-hydroxybenzoyl-CoA + H(+) + NADH + O2 = 2,5-dihydroxybenzoyl-CoA + H2O + NAD(+)"}
{"X":39841,"RHEA_ID":48009,"DIRECTION":"LR","MASTER_ID":48008,"metacyc":"RXN-11740","compounds":"2-hydroxybenzoyl-CoA + H(+) + NADH + O2 => 2,5-dihydroxybenzoyl-CoA + H2O + NAD(+)"}
{"X":39842,"RHEA_ID":38109,"compounds":"L-glyceraldehyde + pyruvate => 2-dehydro-3-deoxy-L-galactonate"}
{"X":39843,"RHEA_ID":48012,"DIRECTION":"UN","MASTER_ID":48012,"ec":"1.14.13.210","compounds":"4-methyl-5-nitrocatechol + NADPH + O2 = 2-hydroxy-5-methylquinone + H(+) + H2O + NADP(+) + nitrite"}
{"X":39844,"RHEA_ID":48013,"DIRECTION":"LR","MASTER_ID":48012,"metacyc":"RXN-8821","compounds":"4-methyl-5-nitrocatechol + NADPH + O2 => 2-hydroxy-5-methylquinone + H(+) + H2O + NADP(+) + nitrite"}
{"X":39845,"RHEA_ID":38113,"DIRECTION":"RL","MASTER_ID":38111,"metacyc":"RXN-11382","compounds":"H(+) + L-glyceraldehyde + NADPH => glycerol + NADP(+)"}
{"X":39846,"RHEA_ID":48016,"DIRECTION":"UN","MASTER_ID":48016,"ec":"1.14.13.210","compounds":"4-methyl-5-nitrocatechol + NADH + O2 = 2-hydroxy-5-methylquinone + H(+) + H2O + NAD(+) + nitrite"}
{"X":39847,"RHEA_ID":48017,"DIRECTION":"LR","MASTER_ID":48016,"metacyc":"RXN-8821","compounds":"4-methyl-5-nitrocatechol + NADH + O2 => 2-hydroxy-5-methylquinone + H(+) + H2O + NAD(+) + nitrite"}
{"X":39848,"RHEA_ID":38117,"compounds":"1-dodecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-dodecanoylglycerol"}
{"X":39849,"RHEA_ID":38118,"compounds":"(9Z)-octadecenoyl-CoA + 1-dodecanoylglycerol <=> 1-dodecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA"}
{"X":39850,"RHEA_ID":48020,"compounds":"globoside Gb3Cer + H2O = beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + D-galactose"}
{"X":39851,"RHEA_ID":48021,"compounds":"globoside Gb3Cer + H2O => beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + D-galactose"}
{"X":39852,"RHEA_ID":38121,"compounds":"1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-tetradecanoylglycerol"}
{"X":39853,"RHEA_ID":38122,"compounds":"(9Z)-octadecenoyl-CoA + 1-tetradecanoylglycerol <=> 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA"}
{"X":39854,"RHEA_ID":48024,"compounds":"1,2,3-tripropanoylglycerol + H2O = dipropanoylglycerol + H(+) + propanoate"}
{"X":39855,"RHEA_ID":48025,"compounds":"1,2,3-tripropanoylglycerol + H2O => dipropanoylglycerol + H(+) + propanoate"}
{"X":39856,"RHEA_ID":38125,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoylglycerol"}
{"X":39857,"RHEA_ID":38126,"compounds":"(9Z)-octadecenoyl-CoA + 1-hexadecanoylglycerol <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA"}
{"X":39858,"RHEA_ID":38127,"compounds":"(9Z)-octadecenoyl-CoA + 1-octadecanoylglycerol = 1-octadecanoyl-2-(9Z)-octadecenoylglycerol + CoA"}
{"X":39859,"RHEA_ID":38128,"compounds":"(9Z)-octadecenoyl-CoA + 1-octadecanoylglycerol => 1-octadecanoyl-2-(9Z)-octadecenoylglycerol + CoA"}
{"X":39860,"RHEA_ID":38129,"compounds":"1-octadecanoyl-2-(9Z)-octadecenoylglycerol + CoA => (9Z)-octadecenoyl-CoA + 1-octadecanoylglycerol"}
{"X":39861,"RHEA_ID":38130,"compounds":"(9Z)-octadecenoyl-CoA + 1-octadecanoylglycerol <=> 1-octadecanoyl-2-(9Z)-octadecenoylglycerol + CoA"}
{"X":39862,"RHEA_ID":38131,"compounds":"(9Z)-octadecenoyl-CoA + 1-(9Z,12Z-octadecadienoyl)-glycerol = 1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA"}
{"X":39863,"RHEA_ID":38132,"compounds":"(9Z)-octadecenoyl-CoA + 1-(9Z,12Z-octadecadienoyl)-glycerol => 1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA"}
{"X":39864,"RHEA_ID":38133,"compounds":"1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z,12Z-octadecadienoyl)-glycerol"}
{"X":39865,"RHEA_ID":38134,"compounds":"(9Z)-octadecenoyl-CoA + 1-(9Z,12Z-octadecadienoyl)-glycerol <=> 1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA"}
{"X":39866,"RHEA_ID":48036,"compounds":"globoside Gb4Cer (d18:1(4E)) + H2O = globoside Gb3Cer (d18:1(4E)) + N-acetyl-beta-D-galactosamine"}
{"X":39867,"RHEA_ID":38136,"compounds":"(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol => 1-(9Z,12Z,15Z-octadecatrienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA"}
{"X":39868,"RHEA_ID":38137,"compounds":"1-(9Z,12Z,15Z-octadecatrienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol"}
{"X":39869,"RHEA_ID":38138,"compounds":"(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol <=> 1-(9Z,12Z,15Z-octadecatrienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA"}
{"X":39870,"RHEA_ID":48040,"compounds":"globoside Gb4Cer + H2O = globoside Gb3Cer + N-acetyl-beta-D-galactosamine"}
{"X":39871,"RHEA_ID":38140,"compounds":"(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerol + CoA"}
{"X":39872,"RHEA_ID":38141,"compounds":"1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol"}
{"X":39873,"RHEA_ID":38142,"compounds":"(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerol + CoA"}
{"X":39874,"RHEA_ID":38143,"DIRECTION":"UN","MASTER_ID":38143,"ec":"3.13.1.5","compounds":"carbon disulfide + 2 H2O = CO2 + 2 H(+) + 2 hydrogen sulfide"}
{"X":39875,"RHEA_ID":48045,"compounds":"ganglioside GM1 (d18:1(4E)/18:0) + H2O => D-galactose + ganglioside GM2 (d18:1(4E)/18:0)"}
{"X":39876,"RHEA_ID":38145,"compounds":"CO2 + 2 H(+) + 2 hydrogen sulfide => carbon disulfide + 2 H2O"}
{"X":39877,"RHEA_ID":38147,"compounds":"carbon disulfide + H2O = carbonyl sulfide + H(+) + hydrogen sulfide"}
{"X":39878,"RHEA_ID":48049,"compounds":"ganglioside GM1 (d18:1(4E)) + H2O => D-galactose + ganglioside GM2 (d18:1(4E))"}
{"X":39879,"RHEA_ID":38149,"compounds":"carbonyl sulfide + H(+) + hydrogen sulfide => carbon disulfide + H2O"}
{"X":39880,"RHEA_ID":48052,"DIRECTION":"UN","MASTER_ID":48052,"ec":"2.8.2.35","compounds":"n 3'-phosphoadenylyl sulfate + dermatan = n adenosine 3',5'-bisphosphate + dermatan 4'-sulfate + n H(+)"}
{"X":39881,"RHEA_ID":48053,"DIRECTION":"LR","MASTER_ID":48052,"metacyc":"RXN-11555","compounds":"n 3'-phosphoadenylyl sulfate + dermatan => n adenosine 3',5'-bisphosphate + dermatan 4'-sulfate + n H(+)"}
{"X":39882,"RHEA_ID":38153,"compounds":"CO2 + H(+) + hydrogen sulfide => carbonyl sulfide + H2O"}
{"X":39883,"RHEA_ID":48056,"compounds":"beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O = beta-D-glucosylceramide + D-galactose"}
{"X":39884,"RHEA_ID":48057,"compounds":"beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O => beta-D-glucosylceramide + D-galactose"}
{"X":39885,"RHEA_ID":38157,"compounds":"(6E,10E)-geranyllinalool + diphosphate => all-trans-geranylgeranyl diphosphate + H2O"}
{"X":39886,"RHEA_ID":48059,"compounds":"beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O <=> beta-D-glucosylceramide + D-galactose"}
{"X":39887,"RHEA_ID":48060,"compounds":"a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H2O = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + D-galactose"}
{"X":39888,"RHEA_ID":48061,"compounds":"a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H2O => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + D-galactose"}
{"X":39889,"RHEA_ID":38161,"compounds":"(2S,3R)-capreomycidine + H2O => (2S,3S)-hydroxyarginine"}
{"X":39890,"RHEA_ID":48063,"compounds":"a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H2O <=> a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + D-galactose"}
{"X":39891,"RHEA_ID":38163,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA"}
{"X":39892,"RHEA_ID":48065,"compounds":"ganglioside GD1b (d18:1(4E)) + H2O => ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate"}
{"X":39893,"RHEA_ID":38165,"compounds":"1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA"}
{"X":39894,"RHEA_ID":38166,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA <=> 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA"}
{"X":39895,"RHEA_ID":48068,"compounds":"ganglioside GM2 (d18:1(4E)) + H2O = ganglioside GA2 (d18:1(4E)) + N-acetylneuraminate"}
{"X":39896,"RHEA_ID":48069,"compounds":"ganglioside GM2 (d18:1(4E)) + H2O => ganglioside GA2 (d18:1(4E)) + N-acetylneuraminate"}
{"X":39897,"RHEA_ID":38169,"compounds":"CoA + hexadecanyl hexadecanoate => hexadecan-1-ol + hexadecanoyl-CoA"}
{"X":39898,"RHEA_ID":38170,"compounds":"hexadecan-1-ol + hexadecanoyl-CoA <=> CoA + hexadecanyl hexadecanoate"}
{"X":39899,"RHEA_ID":48072,"compounds":"ganglioside GM1 (d18:1(4E)) + H2O = ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate"}
{"X":39900,"RHEA_ID":48073,"compounds":"ganglioside GM1 (d18:1(4E)) + H2O => ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate"}
{"X":39901,"RHEA_ID":38173,"compounds":"2-hydroxyhexadecyl hexadecanoate + CoA => hexadecane-1,2-diol + hexadecanoyl-CoA"}
{"X":39902,"RHEA_ID":38174,"compounds":"hexadecane-1,2-diol + hexadecanoyl-CoA <=> 2-hydroxyhexadecyl hexadecanoate + CoA"}
{"X":39903,"RHEA_ID":48076,"compounds":"a primary alcohol + N,N-dimethyl-4-nitrosoaniline = 4-(hydroxylamino)-N,N-dimethylaniline + an aldehyde"}
{"X":39904,"RHEA_ID":48077,"compounds":"a primary alcohol + N,N-dimethyl-4-nitrosoaniline => 4-(hydroxylamino)-N,N-dimethylaniline + an aldehyde"}
{"X":39905,"RHEA_ID":38177,"compounds":"all-trans-retinyl hexadecanoate + CoA => all-trans-retinol + hexadecanoyl-CoA"}
{"X":39906,"RHEA_ID":38178,"compounds":"all-trans-retinol + hexadecanoyl-CoA <=> all-trans-retinyl hexadecanoate + CoA"}
{"X":39907,"RHEA_ID":48080,"DIRECTION":"UN","MASTER_ID":48080,"ec":"1.14.13.190","compounds":"abietatriene + H(+) + NADPH + O2 = ferruginol + H2O + NADP(+)"}
{"X":39908,"RHEA_ID":38180,"DIRECTION":"LR","MASTER_ID":38179,"metacyc":"RXN66-347","compounds":"O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 19-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":39909,"RHEA_ID":38181,"compounds":"19-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone"}
{"X":39910,"RHEA_ID":48083,"compounds":"abietatriene + H(+) + NADPH + O2 <=> ferruginol + H2O + NADP(+)"}
{"X":39911,"RHEA_ID":48096,"DIRECTION":"UN","MASTER_ID":48096,"ec":"2.1.1.319","compounds":"L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine"}
{"X":39912,"RHEA_ID":38184,"DIRECTION":"LR","MASTER_ID":38183,"metacyc":"RXN66-348","compounds":"19-hydroxytestosterone + O2 + reduced [NADPH--hemoprotein reductase] => 19-oxotestosterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":39913,"RHEA_ID":38185,"compounds":"19-oxotestosterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 19-hydroxytestosterone + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":39914,"RHEA_ID":58121,"compounds":"ATP + L-seryl-[protein] => 3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate"}
{"X":39915,"RHEA_ID":48100,"DIRECTION":"UN","MASTER_ID":48100,"ec":"2.1.1.321","compounds":"L-arginyl-[protein] + S-adenosyl-L-methionine = H(+) + N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":39916,"RHEA_ID":38188,"DIRECTION":"LR","MASTER_ID":38187,"metacyc":"RXN66-349","compounds":"19-oxotestosterone + O2 + reduced [NADPH--hemoprotein reductase] => 17beta-estradiol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":39917,"RHEA_ID":38189,"compounds":"17beta-estradiol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 19-oxotestosterone + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":39918,"RHEA_ID":58125,"DIRECTION":"LR","MASTER_ID":58124,"metacyc":"RXN-8224","compounds":"(19S)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + polyneuridine aldehyde"}
{"X":39919,"RHEA_ID":48104,"compounds":"N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine = H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":39920,"RHEA_ID":48105,"DIRECTION":"LR","MASTER_ID":48104,"metacyc":"RXN-16891","compounds":"N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine => H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":39921,"RHEA_ID":38193,"compounds":"17beta-estradiol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone"}
{"X":39922,"RHEA_ID":58129,"compounds":"A + O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine => AH2 + alstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":39923,"RHEA_ID":48108,"DIRECTION":"UN","MASTER_ID":48108,"ec":"2.1.1.320","compounds":"L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine"}
{"X":39924,"RHEA_ID":38196,"DIRECTION":"LR","MASTER_ID":38195,"metacyc":"RXN-14746","compounds":"androst-4-ene-3,17-dione + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => estrone + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}
{"X":39925,"RHEA_ID":38197,"compounds":"estrone + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => androst-4-ene-3,17-dione + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]"}
{"X":39926,"RHEA_ID":58133,"compounds":"A + ajmalicine + O2 + reduced [NADPH--hemoprotein reductase] => AH2 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + serpentine"}
{"X":39927,"RHEA_ID":48112,"compounds":"N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine = H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":39928,"RHEA_ID":38200,"DIRECTION":"LR","MASTER_ID":38199,"metacyc":"RXN66-344","compounds":"androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":39929,"RHEA_ID":38201,"compounds":"19-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":39930,"RHEA_ID":58137,"compounds":"acetate + ATP + H(+) => acetyl-AMP + diphosphate"}
{"X":39931,"RHEA_ID":48116,"DIRECTION":"UN","MASTER_ID":48116,"ec":"2.1.1.322","metacyc":"RXN-16890","compounds":"L-arginyl-[protein] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":39932,"RHEA_ID":38204,"DIRECTION":"LR","MASTER_ID":38203,"metacyc":"RXN66-345","compounds":"19-hydroxyandrost-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] => 19-oxo-androst-4-ene-3,17-dione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":39933,"RHEA_ID":48118,"compounds":"H(+) + N(5)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine => L-arginyl-[protein] + S-adenosyl-L-methionine"}
{"X":39934,"RHEA_ID":58141,"compounds":"acetyl-AMP + cytidine(34) in elongator tRNA(Met) => AMP + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met)"}
{"X":39935,"RHEA_ID":48120,"compounds":"ganglioside GD3 + H2O = ganglioside GM3 + N-acetylneuraminate"}
{"X":39936,"RHEA_ID":38208,"DIRECTION":"LR","MASTER_ID":38207,"metacyc":"RXN66-346","compounds":"19-oxo-androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] => estrone + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":39937,"RHEA_ID":38209,"compounds":"estrone + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 19-oxo-androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":39938,"RHEA_ID":48123,"compounds":"ganglioside GD3 + H2O <=> ganglioside GM3 + N-acetylneuraminate"}
{"X":39939,"RHEA_ID":48124,"compounds":"ganglioside GD3 (d18:1(4E)) + H2O = ganglioside GM3 (d18:1(4E)) + N-acetylneuraminate"}
{"X":39940,"RHEA_ID":38212,"compounds":"hexadecane-1,2-diol + 2 hexadecanoyl-CoA => 1,2-O,O-dihexadecanoyl-1,2-hexadecanediol + 2 CoA"}
{"X":39941,"RHEA_ID":38213,"compounds":"1,2-O,O-dihexadecanoyl-1,2-hexadecanediol + 2 CoA => hexadecane-1,2-diol + 2 hexadecanoyl-CoA"}
{"X":39942,"RHEA_ID":38214,"compounds":"hexadecane-1,2-diol + 2 hexadecanoyl-CoA <=> 1,2-O,O-dihexadecanoyl-1,2-hexadecanediol + 2 CoA"}
{"X":39943,"RHEA_ID":38215,"DIRECTION":"UN","MASTER_ID":38215,"ec":"1.1.1.388","metacyc":"RXN-14819","compounds":"D-glucose 6-phosphate + NAD(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADH"}
{"X":39944,"RHEA_ID":38215,"DIRECTION":"UN","MASTER_ID":38215,"ec":"1.1.1.363","metacyc":"RXN-14819","compounds":"D-glucose 6-phosphate + NAD(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADH"}
{"X":39945,"RHEA_ID":48130,"compounds":"(2E,6E)-farnesyl phosphate + H(+) + phosphate => (2E,6E)-farnesyl diphosphate + H2O"}
{"X":39946,"RHEA_ID":38217,"compounds":"6-phospho-D-glucono-1,5-lactone + H(+) + NADH => D-glucose 6-phosphate + NAD(+)"}
{"X":39947,"RHEA_ID":48132,"compounds":"(2E,6E)-farnesyl phosphate + H2O = (2E,6E)-farnesol + phosphate"}
{"X":39948,"RHEA_ID":38219,"compounds":"(9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA"}
{"X":39949,"RHEA_ID":48134,"compounds":"(2E,6E)-farnesol + phosphate => (2E,6E)-farnesyl phosphate + H2O"}
{"X":39950,"RHEA_ID":38221,"compounds":"1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol"}
{"X":39951,"RHEA_ID":48136,"compounds":"ganglioside GM3 + H2O = beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetylneuraminate"}
{"X":39952,"RHEA_ID":38223,"compounds":"(9Z)-octadecenoyl-CoA + decan-1-ol = 1-O-decyl-(9Z)-octadecenoate + CoA"}
{"X":39953,"RHEA_ID":48138,"compounds":"beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetylneuraminate => ganglioside GM3 + H2O"}
{"X":39954,"RHEA_ID":38225,"compounds":"1-O-decyl-(9Z)-octadecenoate + CoA => (9Z)-octadecenoyl-CoA + decan-1-ol"}
{"X":39955,"RHEA_ID":38226,"compounds":"(9Z)-octadecenoyl-CoA + decan-1-ol <=> 1-O-decyl-(9Z)-octadecenoate + CoA"}
{"X":39956,"RHEA_ID":38227,"compounds":"(9Z)-octadecenoyl-CoA + hexadecan-1-ol = CoA + hexadecanyl (9Z)-octadecenoate"}
{"X":39957,"RHEA_ID":48142,"compounds":"2 oxidized [2Fe-2S]-[ferredoxin] + red chlorophyll catabolite => 2 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":39958,"RHEA_ID":38229,"compounds":"CoA + hexadecanyl (9Z)-octadecenoate => (9Z)-octadecenoyl-CoA + hexadecan-1-ol"}
{"X":39959,"RHEA_ID":38230,"compounds":"(9Z)-octadecenoyl-CoA + hexadecan-1-ol <=> CoA + hexadecanyl (9Z)-octadecenoate"}
{"X":39960,"RHEA_ID":48145,"compounds":"H2O + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-(octadecanoyl)-sphing-4-enine => ganglioside GT1b (d18:1(4E)/18:0) + N-acetylneuraminate"}
{"X":39961,"RHEA_ID":38232,"compounds":"(9Z)-hexadecen-1-ol + (9Z)-octadecenoyl-CoA => 1-O-(9Z)-hexadecenyl (9Z)-octadecenoate + CoA"}
{"X":39962,"RHEA_ID":38233,"compounds":"1-O-(9Z)-hexadecenyl (9Z)-octadecenoate + CoA => (9Z)-hexadecen-1-ol + (9Z)-octadecenoyl-CoA"}
{"X":39963,"RHEA_ID":38234,"compounds":"(9Z)-hexadecen-1-ol + (9Z)-octadecenoyl-CoA <=> 1-O-(9Z)-hexadecenyl (9Z)-octadecenoate + CoA"}
{"X":39964,"RHEA_ID":38235,"compounds":"(9Z)-octadecenoyl-CoA + octadecan-1-ol = 1-O-octadecyl (9Z)-octadecenoate + CoA"}
{"X":39965,"RHEA_ID":58172,"DIRECTION":"UN","MASTER_ID":58172,"ec":"4.2.3.200","compounds":"all-trans-geranylgeranyl diphosphate = beta-pinacene + diphosphate"}
{"X":39966,"RHEA_ID":38237,"compounds":"1-O-octadecyl (9Z)-octadecenoate + CoA => (9Z)-octadecenoyl-CoA + octadecan-1-ol"}
{"X":39967,"RHEA_ID":38238,"compounds":"(9Z)-octadecenoyl-CoA + octadecan-1-ol <=> 1-O-octadecyl (9Z)-octadecenoate + CoA"}
{"X":39968,"RHEA_ID":38239,"compounds":"(9Z)-octadecen-1-ol + (9Z)-octadecenoyl-CoA = 1-O-(9Z)-octadecenyl (9Z)-octadecenoate + CoA"}
{"X":39969,"RHEA_ID":58176,"DIRECTION":"UN","MASTER_ID":58176,"ec":"2.5.1.148","compounds":"2 all-trans-geranylgeranyl diphosphate + H(+) + NADPH = all-trans-lycopaoctaene + 2 diphosphate + NADP(+)"}
{"X":39970,"RHEA_ID":38241,"compounds":"1-O-(9Z)-octadecenyl (9Z)-octadecenoate + CoA => (9Z)-octadecen-1-ol + (9Z)-octadecenoyl-CoA"}
{"X":39971,"RHEA_ID":38242,"compounds":"(9Z)-octadecen-1-ol + (9Z)-octadecenoyl-CoA <=> 1-O-(9Z)-octadecenyl (9Z)-octadecenoate + CoA"}
{"X":39972,"RHEA_ID":38243,"compounds":"(9Z)-octadecenoyl-CoA + eicosan-1-ol = 1-O-eicosanyl (9Z)-octadecenoate + CoA"}
{"X":39973,"RHEA_ID":58180,"compounds":"(1R,2R,3R)-prephytoene diphosphate + H(+) + NADPH = all-trans-lycopaoctaene + diphosphate + NADP(+)"}
{"X":39974,"RHEA_ID":38245,"compounds":"1-O-eicosanyl (9Z)-octadecenoate + CoA => (9Z)-octadecenoyl-CoA + eicosan-1-ol"}
{"X":39975,"RHEA_ID":38246,"compounds":"(9Z)-octadecenoyl-CoA + eicosan-1-ol <=> 1-O-eicosanyl (9Z)-octadecenoate + CoA"}
{"X":39976,"RHEA_ID":38247,"compounds":"(9Z)-hexadecenoyl-CoA + hexadecan-1-ol = 1-O-hexadecyl (9Z)-hexadecenoate + CoA"}
{"X":39977,"RHEA_ID":58184,"DIRECTION":"UN","MASTER_ID":58184,"ec":"2.5.1.148","compounds":"H(+) + NADPH + 2 phytyl diphosphate = (14E,18E)-lycopadiene + 2 diphosphate + NADP(+)"}
{"X":39978,"RHEA_ID":38249,"compounds":"1-O-hexadecyl (9Z)-hexadecenoate + CoA => (9Z)-hexadecenoyl-CoA + hexadecan-1-ol"}
{"X":39979,"RHEA_ID":38250,"compounds":"(9Z)-hexadecenoyl-CoA + hexadecan-1-ol <=> 1-O-hexadecyl (9Z)-hexadecenoate + CoA"}
{"X":39980,"RHEA_ID":38251,"compounds":"hexadecan-1-ol + octadecanoyl-CoA = CoA + hexadecanyl octadecanoate"}
{"X":39981,"RHEA_ID":58188,"DIRECTION":"UN","MASTER_ID":58188,"ec":"2.5.1.150","compounds":"all-trans-lycopene + dimethylallyl diphosphate + H2O = dihydroisopentenyldehydrorhodopin + diphosphate"}
{"X":39982,"RHEA_ID":38253,"compounds":"CoA + hexadecanyl octadecanoate => hexadecan-1-ol + octadecanoyl-CoA"}
{"X":39983,"RHEA_ID":38254,"compounds":"hexadecan-1-ol + octadecanoyl-CoA <=> CoA + hexadecanyl octadecanoate"}
{"X":39984,"RHEA_ID":38255,"DIRECTION":"UN","MASTER_ID":38255,"ec":"2.8.3.22","compounds":"(S)-malate + succinyl-CoA = (S)-malyl-CoA + succinate"}
{"X":39985,"RHEA_ID":48170,"compounds":"N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine + N-acetylneuraminate => H2O + N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine"}
{"X":39986,"RHEA_ID":38257,"compounds":"(S)-malyl-CoA + succinate => (S)-malate + succinyl-CoA"}
{"X":39987,"RHEA_ID":48172,"compounds":"ganglioside GM2 + H2O = N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetylneuraminate"}
{"X":39988,"RHEA_ID":38259,"DIRECTION":"UN","MASTER_ID":38259,"ec":"4.1.3.24","compounds":"(2R,3S)-beta-methylmalyl-CoA = glyoxylate + propanoyl-CoA"}
{"X":39989,"RHEA_ID":48174,"compounds":"N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetylneuraminate => ganglioside GM2 + H2O"}
{"X":39990,"RHEA_ID":38261,"compounds":"glyoxylate + propanoyl-CoA => (2R,3S)-beta-methylmalyl-CoA"}
{"X":39991,"RHEA_ID":48176,"compounds":"decanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-decenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":39992,"RHEA_ID":38263,"DIRECTION":"UN","MASTER_ID":38263,"ec":"4.2.1.148","compounds":"(2R,3S)-beta-methylmalyl-CoA = 2-methylfumaryl-CoA + H2O"}
{"X":39993,"RHEA_ID":48178,"compounds":"(2E)-decenoyl-CoA + reduced [electron-transfer flavoprotein] => decanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":39994,"RHEA_ID":48179,"compounds":"decanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-decenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":39995,"RHEA_ID":48180,"compounds":"H(+) + octanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-octenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":39996,"RHEA_ID":38267,"DIRECTION":"UN","MASTER_ID":38267,"ec":"5.4.1.3","compounds":"2-methylfumaryl-CoA = 3-methylfumaryl-CoA"}
{"X":39997,"RHEA_ID":38268,"compounds":"2-methylfumaryl-CoA => 3-methylfumaryl-CoA"}
{"X":39998,"RHEA_ID":48183,"compounds":"H(+) + octanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> (2E)-octenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":39999,"RHEA_ID":48184,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":40000,"RHEA_ID":38271,"DIRECTION":"UN","MASTER_ID":38271,"ec":"4.2.1.153","compounds":"(3S)-citramalyl-CoA = 3-methylfumaryl-CoA + H2O"}
{"X":40001,"RHEA_ID":48186,"compounds":"(2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + reduced [electron-transfer flavoprotein] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":40002,"RHEA_ID":38273,"DIRECTION":"RL","MASTER_ID":38271,"metacyc":"RXN-8965","compounds":"3-methylfumaryl-CoA + H2O => (3S)-citramalyl-CoA"}
{"X":40003,"RHEA_ID":48188,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,9Z,12Z)-octadecatrienoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":40004,"RHEA_ID":38275,"DIRECTION":"UN","MASTER_ID":38275,"ec":"4.1.3.46","compounds":"(3R)-citramalyl-CoA = acetyl-CoA + pyruvate"}
{"X":40005,"RHEA_ID":48190,"compounds":"(2E,9Z,12Z)-octadecatrienoyl-CoA + reduced [electron-transfer flavoprotein] => (9Z,12Z)-octadecadienoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":40006,"RHEA_ID":48191,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,9Z,12Z)-octadecatrienoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":40007,"RHEA_ID":48192,"compounds":"(9E)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,9E)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":40008,"RHEA_ID":38279,"DIRECTION":"UN","MASTER_ID":38279,"ec":"2.8.3.20","compounds":"(3R)-citramalate + succinyl-CoA = (3R)-citramalyl-CoA + succinate"}
{"X":40009,"RHEA_ID":38280,"compounds":"(3R)-citramalate + succinyl-CoA => (3R)-citramalyl-CoA + succinate"}
{"X":40010,"RHEA_ID":38281,"compounds":"(3R)-citramalyl-CoA + succinate => (3R)-citramalate + succinyl-CoA"}
{"X":40011,"RHEA_ID":58218,"compounds":"AH2 + serpentine => A + dihydroserpentine"}
{"X":40012,"RHEA_ID":38283,"DIRECTION":"UN","MASTER_ID":38283,"ec":"2.8.3.22","compounds":"itaconate + succinyl-CoA = itaconyl-CoA + succinate"}
{"X":40013,"RHEA_ID":38284,"DIRECTION":"LR","MASTER_ID":38283,"metacyc":"RXN-8987","compounds":"itaconate + succinyl-CoA => itaconyl-CoA + succinate"}
{"X":40014,"RHEA_ID":38285,"compounds":"itaconyl-CoA + succinate => itaconate + succinyl-CoA"}
{"X":40015,"RHEA_ID":58222,"compounds":"H(+) + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide => L-lysyl-[protein] + NAD(+)"}
{"X":40016,"RHEA_ID":38287,"DIRECTION":"UN","MASTER_ID":38287,"ec":"2.8.3.22","compounds":"(3S)-citramalate + succinyl-CoA = (3S)-citramalyl-CoA + succinate"}
{"X":40017,"RHEA_ID":48202,"compounds":"reduced [electron-transfer flavoprotein] + trans-2-undecenoyl-CoA => H(+) + oxidized [electron-transfer flavoprotein] + undecanoyl-CoA"}
{"X":40018,"RHEA_ID":38289,"compounds":"(3S)-citramalyl-CoA + succinate => (3S)-citramalate + succinyl-CoA"}
{"X":40019,"RHEA_ID":48204,"compounds":"H(+) + oxidized [electron-transfer flavoprotein] + pentadecanoyl-CoA = (2E)-pentadecenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":40020,"RHEA_ID":38291,"DIRECTION":"UN","MASTER_ID":38291,"ec":"3.1.2.30","compounds":"(S)-malyl-CoA + H2O = (S)-malate + CoA + H(+)"}
{"X":40021,"RHEA_ID":48206,"compounds":"(2E)-pentadecenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + pentadecanoyl-CoA"}
{"X":40022,"RHEA_ID":38293,"compounds":"(S)-malate + CoA + H(+) => (S)-malyl-CoA + H2O"}
{"X":40023,"RHEA_ID":58230,"compounds":"H(+) + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] + nicotinamide => L-asparaginyl-[protein] + NAD(+)"}
{"X":40024,"RHEA_ID":38295,"DIRECTION":"UN","MASTER_ID":38295,"ec":"1.1.99.39","compounds":"(R)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2"}
{"X":40025,"RHEA_ID":38296,"DIRECTION":"LR","MASTER_ID":38295,"metacyc":"RXN-14932","compounds":"(R)-2-hydroxyglutarate + A => 2-oxoglutarate + AH2"}
{"X":40026,"RHEA_ID":38297,"compounds":"2-oxoglutarate + AH2 => (R)-2-hydroxyglutarate + A"}
{"X":40027,"RHEA_ID":58234,"compounds":"H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein] => L-seryl-[protein] + NAD(+)"}
{"X":40028,"RHEA_ID":38299,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA"}
{"X":40029,"RHEA_ID":38300,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA => 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA"}
{"X":40030,"RHEA_ID":38301,"compounds":"1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA"}
{"X":40031,"RHEA_ID":48216,"compounds":"H(+) + hexacosanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-hexacosenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":40032,"RHEA_ID":38303,"DIRECTION":"UN","MASTER_ID":38303,"ec":"4.3.1.29","compounds":"2-amino-2-deoxy-D-gluconate 6-phosphate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + NH4(+)"}
{"X":40033,"RHEA_ID":38304,"DIRECTION":"LR","MASTER_ID":38303,"metacyc":"RXN-14730","compounds":"2-amino-2-deoxy-D-gluconate 6-phosphate => 2-dehydro-3-deoxy-6-phospho-D-gluconate + NH4(+)"}
{"X":40034,"RHEA_ID":38305,"compounds":"2-dehydro-3-deoxy-6-phospho-D-gluconate + NH4(+) => 2-amino-2-deoxy-D-gluconate 6-phosphate"}
{"X":40035,"RHEA_ID":58242,"compounds":"ADP-D-ribose + L-cysteinyl-[protein] => H2O + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]"}
{"X":40036,"RHEA_ID":38307,"compounds":"(9Z)-octadecenoyl-CoA + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA"}
{"X":40037,"RHEA_ID":38308,"compounds":"(9Z)-octadecenoyl-CoA + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA"}
{"X":40038,"RHEA_ID":38309,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol"}
{"X":40039,"RHEA_ID":48224,"compounds":"a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O = a neolactoside nLc4Cer(d18:1(4E)) + L-fucose"}
{"X":40040,"RHEA_ID":38311,"DIRECTION":"UN","MASTER_ID":38311,"ec":"2.1.1.292","compounds":"carminomycin + S-adenosyl-L-methionine = daunorubicin + H(+) + S-adenosyl-L-homocysteine"}
{"X":40041,"RHEA_ID":38312,"compounds":"carminomycin + S-adenosyl-L-methionine => daunorubicin + H(+) + S-adenosyl-L-homocysteine"}
{"X":40042,"RHEA_ID":38313,"compounds":"daunorubicin + H(+) + S-adenosyl-L-homocysteine => carminomycin + S-adenosyl-L-methionine"}
{"X":40043,"RHEA_ID":48228,"DIRECTION":"UN","MASTER_ID":48228,"ec":"2.3.1.269","compounds":"a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 1-lyso-glycerophospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]"}
{"X":40044,"RHEA_ID":38315,"DIRECTION":"UN","MASTER_ID":38315,"ec":"4.1.3.45","compounds":"chorismate = 3-hydroxybenzoate + pyruvate"}
{"X":40045,"RHEA_ID":38316,"compounds":"chorismate => 3-hydroxybenzoate + pyruvate"}
{"X":40046,"RHEA_ID":38317,"compounds":"3-hydroxybenzoate + pyruvate => chorismate"}
{"X":40047,"RHEA_ID":58254,"compounds":"ADP-D-ribose + L-asparaginyl-[protein] => H2O + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein]"}
{"X":40048,"RHEA_ID":38319,"DIRECTION":"UN","MASTER_ID":38319,"ec":"3.3.2.13","compounds":"chorismate + H2O = (3R,4R)-3,4-dihydroxy-3,4-dihydrobenzoate + pyruvate"}
{"X":40049,"RHEA_ID":38320,"compounds":"chorismate + H2O => (3R,4R)-3,4-dihydroxy-3,4-dihydrobenzoate + pyruvate"}
{"X":40050,"RHEA_ID":38321,"compounds":"(3R,4R)-3,4-dihydroxy-3,4-dihydrobenzoate + pyruvate => chorismate + H2O"}
{"X":40051,"RHEA_ID":48236,"DIRECTION":"UN","MASTER_ID":48236,"ec":"2.3.1.272","compounds":"2 2-acetylphloroglucinol = 1,3,5-trihydroxybenzene + 2,4-diacetylphloroglucinol + H(+)"}
{"X":40052,"RHEA_ID":38323,"compounds":"2 1-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-glycerol + glycerol"}
{"X":40053,"RHEA_ID":48238,"compounds":"1,3,5-trihydroxybenzene + 2,4-diacetylphloroglucinol + H(+) => 2 2-acetylphloroglucinol"}
{"X":40054,"RHEA_ID":38325,"compounds":"1,2-di-(9Z-octadecenoyl)-glycerol + glycerol => 2 1-(9Z-octadecenoyl)-glycerol"}
{"X":40055,"RHEA_ID":38326,"compounds":"2 1-(9Z-octadecenoyl)-glycerol <=> 1,2-di-(9Z-octadecenoyl)-glycerol + glycerol"}
{"X":40056,"RHEA_ID":38327,"compounds":"1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol"}
{"X":40057,"RHEA_ID":38328,"compounds":"1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol"}
{"X":40058,"RHEA_ID":38329,"compounds":"1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol => 1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol"}
{"X":40059,"RHEA_ID":38330,"compounds":"1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol"}
{"X":40060,"RHEA_ID":38331,"compounds":"1,3-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol"}
{"X":40061,"RHEA_ID":48246,"compounds":"CMP + ganglioside GM1b + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GA1"}
{"X":40062,"RHEA_ID":38333,"compounds":"1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol => 1,3-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol"}
{"X":40063,"RHEA_ID":38334,"compounds":"1,3-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol"}
{"X":40064,"RHEA_ID":38335,"DIRECTION":"UN","MASTER_ID":38335,"ec":"3.2.1.192","compounds":"(20S)-ginsenoside Rb1 + 2 H2O = (20S)-ginsenoside Rg3 + 2 D-glucose"}
{"X":40065,"RHEA_ID":48250,"compounds":"CMP + ganglioside GD1a (18:1(4E)/18:0) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)/18:0)"}
{"X":40066,"RHEA_ID":38337,"compounds":"(20S)-ginsenoside Rg3 + 2 D-glucose => (20S)-ginsenoside Rb1 + 2 H2O"}
{"X":40067,"RHEA_ID":38338,"DIRECTION":"BI","MASTER_ID":38335,"metacyc":"RXN-14630","compounds":"(20S)-ginsenoside Rb1 + 2 H2O <=> (20S)-ginsenoside Rg3 + 2 D-glucose"}
{"X":40068,"RHEA_ID":38339,"DIRECTION":"UN","MASTER_ID":38339,"ec":"3.2.1.195","compounds":"(20S)-ginsenoside Rb1 + H2O = (20S)-ginsenoside Rd + D-glucose"}
{"X":40069,"RHEA_ID":38340,"DIRECTION":"LR","MASTER_ID":38339,"metacyc":"RXN-11132","compounds":"(20S)-ginsenoside Rb1 + H2O => (20S)-ginsenoside Rd + D-glucose"}
{"X":40070,"RHEA_ID":38341,"compounds":"(20S)-ginsenoside Rd + D-glucose => (20S)-ginsenoside Rb1 + H2O"}
{"X":40071,"RHEA_ID":38342,"compounds":"(20S)-ginsenoside Rb1 + H2O <=> (20S)-ginsenoside Rd + D-glucose"}
{"X":40072,"RHEA_ID":38343,"compounds":"(20S)-ginsenoside Rd + H2O = (20S)-ginsenoside Rg3 + D-glucose"}
{"X":40073,"RHEA_ID":48258,"compounds":"(2E)-2-methylbutenoyl-CoA + reduced [electron-transfer flavoprotein] => (2S)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":40074,"RHEA_ID":38345,"compounds":"(20S)-ginsenoside Rg3 + D-glucose => (20S)-ginsenoside Rd + H2O"}
{"X":40075,"RHEA_ID":38346,"compounds":"(20S)-ginsenoside Rd + H2O <=> (20S)-ginsenoside Rg3 + D-glucose"}
{"X":40076,"RHEA_ID":38347,"DIRECTION":"UN","MASTER_ID":38347,"ec":"2.6.1.103","compounds":"(S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate = 2-(3,5-dihydroxyphenyl)-2-oxoacetate + L-glutamate"}
{"X":40077,"RHEA_ID":48262,"compounds":"CMP + ganglioside GD1a + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM1a"}
{"X":40078,"RHEA_ID":38349,"compounds":"2-(3,5-dihydroxyphenyl)-2-oxoacetate + L-glutamate => (S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate"}
{"X":40079,"RHEA_ID":48264,"DIRECTION":"UN","MASTER_ID":48264,"ec":"3.1.6.20","compounds":"H2O + S-sulfosulfanyl-L-cysteinyl-[SoxY protein] = H(+) + S-sulfanyl-L-cysteinyl-[SoxY protein] + sulfate"}
{"X":40080,"RHEA_ID":38351,"DIRECTION":"UN","MASTER_ID":38351,"ec":"1.1.1.110","compounds":"(R)-3-phenyllactate + NAD(+) = 3-phenylpyruvate + H(+) + NADH"}
{"X":40081,"RHEA_ID":48266,"compounds":"H(+) + S-sulfanyl-L-cysteinyl-[SoxY protein] + sulfate => H2O + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]"}
{"X":40082,"RHEA_ID":38353,"DIRECTION":"RL","MASTER_ID":38351,"metacyc":"RXN-10816","compounds":"3-phenylpyruvate + H(+) + NADH => (R)-3-phenyllactate + NAD(+)"}
{"X":40083,"RHEA_ID":38354,"compounds":"(R)-3-phenyllactate + NAD(+) <=> 3-phenylpyruvate + H(+) + NADH"}
{"X":40084,"RHEA_ID":38355,"DIRECTION":"UN","MASTER_ID":38355,"ec":"4.2.1.175","compounds":"(R)-3-phenyllactoyl-CoA = (E)-cinnamoyl-CoA + H2O"}
{"X":40085,"RHEA_ID":48270,"compounds":"canthaxanthin + H2O => 4',4'-dihydroxyechinenone"}
{"X":40086,"RHEA_ID":38357,"compounds":"(E)-cinnamoyl-CoA + H2O => (R)-3-phenyllactoyl-CoA"}
{"X":40087,"RHEA_ID":48272,"compounds":"2-methylhexanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = 2-methylhexenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":40088,"RHEA_ID":38359,"compounds":"2 H(+) + hydrogen sulfide + sulfite + ubiquinone-10 = thiosulfate + ubiquinol-10"}
{"X":40089,"RHEA_ID":48274,"compounds":"2-methylhexenoyl-CoA + reduced [electron-transfer flavoprotein] => 2-methylhexanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":40090,"RHEA_ID":38361,"compounds":"thiosulfate + ubiquinol-10 => 2 H(+) + hydrogen sulfide + sulfite + ubiquinone-10"}
{"X":40091,"RHEA_ID":38362,"compounds":"2 H(+) + hydrogen sulfide + sulfite + ubiquinone-10 <=> thiosulfate + ubiquinol-10"}
{"X":40092,"RHEA_ID":38363,"compounds":"1-octadecanoylglycerol + H2O = glycerol + H(+) + octadecanoate"}
{"X":40093,"RHEA_ID":48278,"compounds":"beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetyl-beta-D-galactosamine => H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide"}
{"X":40094,"RHEA_ID":38365,"compounds":"glycerol + H(+) + octadecanoate => 1-octadecanoylglycerol + H2O"}
{"X":40095,"RHEA_ID":48280,"compounds":"ganglioside GM2 + UDP-alpha-D-galactose = ganglioside GM1a + H(+) + UDP"}
{"X":40096,"RHEA_ID":38367,"DIRECTION":"UN","MASTER_ID":38367,"ec":"2.3.1.260","compounds":"8 H(+) + malonamoyl-[OxyC ACP] + 8 malonyl-CoA = 18-carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[OxyC ACP] + 8 CO2 + 8 CoA"}
{"X":40097,"RHEA_ID":48282,"compounds":"ganglioside GM1a + H(+) + UDP => ganglioside GM2 + UDP-alpha-D-galactose"}
{"X":40098,"RHEA_ID":38369,"compounds":"18-carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[OxyC ACP] + 8 CO2 + 8 CoA => 8 H(+) + malonamoyl-[OxyC ACP] + 8 malonyl-CoA"}
{"X":40099,"RHEA_ID":48284,"compounds":"globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose = globoside NOR1 (d18:1(4E)) + H(+) + UDP"}
{"X":40100,"RHEA_ID":38371,"compounds":"1-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+)"}
{"X":40101,"RHEA_ID":38372,"compounds":"1-(9Z-octadecenoyl)-sn-glycerol + H2O => (9Z)-octadecenoate + glycerol + H(+)"}
{"X":40102,"RHEA_ID":38373,"compounds":"(9Z)-octadecenoate + glycerol + H(+) => 1-(9Z-octadecenoyl)-sn-glycerol + H2O"}
{"X":40103,"RHEA_ID":48288,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GM3 = CMP + ganglioside GD3 + H(+)"}
{"X":40104,"RHEA_ID":38375,"DIRECTION":"UN","MASTER_ID":38375,"ec":"4.2.1.161","compounds":"bacterioruberin = bisanhydrobacterioruberin + 2 H2O"}
{"X":40105,"RHEA_ID":48290,"compounds":"CMP + ganglioside GD3 + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM3"}
{"X":40106,"RHEA_ID":38377,"compounds":"bisanhydrobacterioruberin + 2 H2O => bacterioruberin"}
{"X":40107,"RHEA_ID":48292,"compounds":"ganglioside GM1a + GDP-beta-L-fucose = fucosyl ganglioside GM1 + GDP + H(+)"}
{"X":40108,"RHEA_ID":38379,"compounds":"(9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H(+) = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O"}
{"X":40109,"RHEA_ID":48294,"compounds":"fucosyl ganglioside GM1 + GDP + H(+) => ganglioside GM1a + GDP-beta-L-fucose"}
{"X":40110,"RHEA_ID":38381,"compounds":"1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H(+)"}
{"X":40111,"RHEA_ID":48296,"compounds":"H2O + prostaglandin E2 1-glyceryl ester = glycerol + H(+) + prostaglandin E2"}
{"X":40112,"RHEA_ID":38383,"compounds":"2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)"}
{"X":40113,"RHEA_ID":38384,"compounds":"2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)"}
{"X":40114,"RHEA_ID":38385,"compounds":"(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+) => 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O"}
{"X":40115,"RHEA_ID":48300,"compounds":"H2O + prostaglandin F2alpha 1-glyceryl ester = glycerol + H(+) + prostaglandin F2alpha"}
{"X":40116,"RHEA_ID":38387,"compounds":"1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 1,3-di-(9Z-octadecenoyl)-glycerol + H(+)"}
{"X":40117,"RHEA_ID":38388,"compounds":"1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 1,3-di-(9Z-octadecenoyl)-glycerol + H(+)"}
{"X":40118,"RHEA_ID":38389,"compounds":"(9Z)-octadecenoate + 1,3-di-(9Z-octadecenoyl)-glycerol + H(+) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O"}
{"X":40119,"RHEA_ID":38390,"compounds":"1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 1,3-di-(9Z-octadecenoyl)-glycerol + H(+)"}
{"X":40120,"RHEA_ID":38391,"compounds":"1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+)"}
{"X":40121,"RHEA_ID":48306,"compounds":"a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+) => a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose"}
{"X":40122,"RHEA_ID":38393,"compounds":"(9Z)-octadecenoate + 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O"}
{"X":40123,"RHEA_ID":48308,"DIRECTION":"UN","MASTER_ID":48308,"ec":"4.1.2.44","compounds":"2,3-epoxy-2,3-dihydrobenzoyl-CoA + 2 H2O = (3Z)-6-oxohex-3-enoyl-CoA + formate + H(+)"}
{"X":40124,"RHEA_ID":38395,"compounds":"1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O = (9Z)-hexadecenoate + 1,3-di-(9Z)-hexadecenoylglycerol + H(+)"}
{"X":40125,"RHEA_ID":48310,"compounds":"(3Z)-6-oxohex-3-enoyl-CoA + formate + H(+) => 2,3-epoxy-2,3-dihydrobenzoyl-CoA + 2 H2O"}
{"X":40126,"RHEA_ID":38397,"compounds":"(9Z)-hexadecenoate + 1,3-di-(9Z)-hexadecenoylglycerol + H(+) => 1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O"}
{"X":40127,"RHEA_ID":38398,"compounds":"1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O <=> (9Z)-hexadecenoate + 1,3-di-(9Z)-hexadecenoylglycerol + H(+)"}
{"X":40128,"RHEA_ID":38399,"compounds":"1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O = (9Z)-hexadecenoate + 2,3-di-(9Z)-hexadecenoyl-sn-glycerol + H(+)"}
{"X":40129,"RHEA_ID":38400,"compounds":"1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O => (9Z)-hexadecenoate + 2,3-di-(9Z)-hexadecenoyl-sn-glycerol + H(+)"}
{"X":40130,"RHEA_ID":58341,"compounds":"beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O => chenodeoxycholate + D-glucose"}
{"X":40131,"RHEA_ID":38402,"compounds":"1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O <=> (9Z)-hexadecenoate + 2,3-di-(9Z)-hexadecenoyl-sn-glycerol + H(+)"}
{"X":40132,"RHEA_ID":38403,"compounds":"1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = (9Z,12Z)-octadecadienoate + 1,3-di-(9Z,12Z)-octadecadienoylglycerol + H(+)"}
{"X":40133,"RHEA_ID":38404,"compounds":"1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O => (9Z,12Z)-octadecadienoate + 1,3-di-(9Z,12Z)-octadecadienoylglycerol + H(+)"}
{"X":40134,"RHEA_ID":38405,"compounds":"(9Z,12Z)-octadecadienoate + 1,3-di-(9Z,12Z)-octadecadienoylglycerol + H(+) => 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O"}
{"X":40135,"RHEA_ID":48320,"compounds":"ganglioside GA1 + GDP-beta-L-fucose = fucosyl ganglioside GA1 + GDP + H(+)"}
{"X":40136,"RHEA_ID":38407,"compounds":"1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = (9Z,12Z)-octadecadienoate + 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + H(+)"}
{"X":40137,"RHEA_ID":38408,"compounds":"1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O => (9Z,12Z)-octadecadienoate + 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + H(+)"}
{"X":40138,"RHEA_ID":38409,"compounds":"(9Z,12Z)-octadecadienoate + 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + H(+) => 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O"}
{"X":40139,"RHEA_ID":48324,"compounds":"ganglioside GD1b + GDP-beta-L-fucose = ganglioside fucosyl GD1b + GDP + H(+)"}
{"X":40140,"RHEA_ID":48325,"compounds":"ganglioside GD1b + GDP-beta-L-fucose => ganglioside fucosyl GD1b + GDP + H(+)"}
{"X":40141,"RHEA_ID":38412,"compounds":"1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O => (9Z,12Z,15Z)-octadecatrienoate + 1,3-di-(9Z,12Z,15Z)-octadecatrienoylglycerol + H(+)"}
{"X":40142,"RHEA_ID":38413,"compounds":"(9Z,12Z,15Z)-octadecatrienoate + 1,3-di-(9Z,12Z,15Z)-octadecatrienoylglycerol + H(+) => 1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O"}
{"X":40143,"RHEA_ID":38414,"compounds":"1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O <=> (9Z,12Z,15Z)-octadecatrienoate + 1,3-di-(9Z,12Z,15Z)-octadecatrienoylglycerol + H(+)"}
{"X":40144,"RHEA_ID":38415,"compounds":"1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O = (9Z,12Z,15Z)-octadecatrienoate + 2,3-di-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycerol + H(+)"}
{"X":40145,"RHEA_ID":38416,"compounds":"1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O => (9Z,12Z,15Z)-octadecatrienoate + 2,3-di-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycerol + H(+)"}
{"X":40146,"RHEA_ID":38417,"compounds":"(9Z,12Z,15Z)-octadecatrienoate + 2,3-di-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycerol + H(+) => 1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O"}
{"X":40147,"RHEA_ID":48332,"compounds":"a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose = a neolactoside III(3)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)"}
{"X":40148,"RHEA_ID":38419,"compounds":"1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O = 1,3-di-(9Z-octadecenoyl)-glycerol + H(+) + hexadecanoate"}
{"X":40149,"RHEA_ID":38420,"compounds":"1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O => 1,3-di-(9Z-octadecenoyl)-glycerol + H(+) + hexadecanoate"}
{"X":40150,"RHEA_ID":38421,"compounds":"1,3-di-(9Z-octadecenoyl)-glycerol + H(+) + hexadecanoate => 1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O"}
{"X":40151,"RHEA_ID":38422,"compounds":"1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O <=> 1,3-di-(9Z-octadecenoyl)-glycerol + H(+) + hexadecanoate"}
{"X":40152,"RHEA_ID":38423,"compounds":"1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H(+)"}
{"X":40153,"RHEA_ID":48338,"compounds":"a neolactoside III(3)-alpha-Fuc-nLc6Cer(d18:1(4E)) + GDP + H(+) => a neolactoside nLc6Cer(d18:1(4E)) + GDP-beta-L-fucose"}
{"X":40154,"RHEA_ID":38425,"compounds":"(9Z)-octadecenoate + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H(+) => 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O"}
{"X":40155,"RHEA_ID":38426,"compounds":"1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H(+)"}
{"X":40156,"RHEA_ID":48341,"compounds":"a medium chain fatty acid + ATP + CoA => a medium-chain fatty acyl-CoA + AMP + diphosphate"}
{"X":40157,"RHEA_ID":48342,"compounds":"a medium-chain fatty acyl-CoA + AMP + diphosphate => a medium chain fatty acid + ATP + CoA"}
{"X":40158,"RHEA_ID":38429,"compounds":"2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+) + hexadecanoate => 1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O"}
{"X":40159,"RHEA_ID":38430,"compounds":"1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O <=> 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+) + hexadecanoate"}
{"X":40160,"RHEA_ID":38431,"compounds":"1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O = (9Z)-octadecenoate + 2-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+)"}
{"X":40161,"RHEA_ID":48346,"compounds":"a D-galactosylceramide + H(+) + UDP => N-acyl-sphingoid base + UDP-alpha-D-galactose"}
{"X":40162,"RHEA_ID":41751,"compounds":"3'-phosphoadenylyl sulfate + a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol <=> 3-O-sulfo-beta-D-galactosyl-diacylglycerol + adenosine 3',5'-bisphosphate + H(+)"}
{"X":40163,"RHEA_ID":38434,"compounds":"1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O <=> (9Z)-octadecenoate + 2-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+)"}
{"X":40164,"RHEA_ID":38435,"compounds":"(9Z)-octadecenoyl-CoA + 1,3-di-(9Z-octadecenoyl)-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA"}
{"X":40165,"RHEA_ID":38436,"compounds":"(9Z)-octadecenoyl-CoA + 1,3-di-(9Z-octadecenoyl)-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA"}
{"X":40166,"RHEA_ID":41755,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H(+)"}
{"X":40167,"RHEA_ID":38438,"compounds":"(9Z)-octadecenoyl-CoA + 1,3-di-(9Z-octadecenoyl)-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA"}
{"X":40168,"RHEA_ID":38439,"compounds":"(9Z)-octadecenoyl-CoA + 2,3-di-(9Z)-octadecenoyl-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA"}
{"X":40169,"RHEA_ID":48354,"compounds":"GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide"}
{"X":40170,"RHEA_ID":38441,"compounds":"1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 2,3-di-(9Z)-octadecenoyl-sn-glycerol"}
{"X":40171,"RHEA_ID":38442,"compounds":"(9Z)-octadecenoyl-CoA + 2,3-di-(9Z)-octadecenoyl-sn-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA"}
{"X":40172,"RHEA_ID":38443,"DIRECTION":"UN","MASTER_ID":38443,"ec":"2.3.1.75","compounds":"a long chain fatty alcohol + an acyl-CoA = a wax ester + CoA"}
{"X":40173,"RHEA_ID":48358,"compounds":"GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide"}
{"X":40174,"RHEA_ID":38445,"compounds":"a wax ester + CoA => a long chain fatty alcohol + an acyl-CoA"}
{"X":40175,"RHEA_ID":48361,"compounds":"a 1,2-saturated fatty acid + H2O2 => a 2-hydroxy fatty acid + H2O"}
{"X":40176,"RHEA_ID":48362,"compounds":"a 2-hydroxy fatty acid + H2O => a 1,2-saturated fatty acid + H2O2"}
{"X":40177,"RHEA_ID":38449,"compounds":"4-O-(beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose => 4-O-(beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + H2O"}
{"X":40178,"RHEA_ID":48364,"compounds":"beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose = beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)"}
{"X":40179,"RHEA_ID":38451,"DIRECTION":"UN","MASTER_ID":38451,"ec":"1.8.1.19","compounds":"hydrogen sulfide + NADP(+) + n sulfur = NADPH + (n+1) sulfur"}
{"X":40180,"RHEA_ID":48366,"compounds":"beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+) => beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose"}
{"X":40181,"RHEA_ID":38453,"compounds":"NADPH + (n+1) sulfur => hydrogen sulfide + NADP(+) + n sulfur"}
{"X":40182,"RHEA_ID":48369,"compounds":"beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose => beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)"}
{"X":40183,"RHEA_ID":38456,"compounds":"1,2-di-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)"}
{"X":40184,"RHEA_ID":38457,"compounds":"(9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+) => 1,2-di-(9Z-octadecenoyl)-glycerol + H2O"}
{"X":40185,"RHEA_ID":38458,"compounds":"1,2-di-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)"}
{"X":40186,"RHEA_ID":38459,"DIRECTION":"UN","MASTER_ID":38459,"ec":"2.3.1.278","compounds":"2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + a mycolipenoyl-CoA = 2-O-(long-chain fatty acyl)-3-O-mycolipenoyl-trehalose + CoA"}
{"X":40187,"RHEA_ID":48374,"compounds":"a fatty acid + acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) => 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O"}
{"X":40188,"RHEA_ID":38461,"compounds":"2-O-(long-chain fatty acyl)-3-O-mycolipenoyl-trehalose + CoA => 2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + a mycolipenoyl-CoA"}
{"X":40189,"RHEA_ID":38463,"compounds":"a 1-acyl-sn-glycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA"}
{"X":40190,"RHEA_ID":48378,"compounds":"a neolactoside III(3)-alpha-Fuc-nLc4Cer + GDP + H(+) => a neolactoside nLc4Cer + GDP-beta-L-fucose"}
{"X":40191,"RHEA_ID":38465,"compounds":"a 1,2-diacyl-sn-glycerol + CoA => a 1-acyl-sn-glycerol + an acyl-CoA"}
{"X":40192,"RHEA_ID":38466,"compounds":"a 1-acyl-sn-glycerol + an acyl-CoA <=> a 1,2-diacyl-sn-glycerol + CoA"}
{"X":40193,"RHEA_ID":38471,"DIRECTION":"UN","MASTER_ID":38471,"ec":"2.1.1.44","compounds":"L-histidine + 3 S-adenosyl-L-methionine = 3 H(+) + hercynine + 3 S-adenosyl-L-homocysteine"}
{"X":40194,"RHEA_ID":48382,"compounds":"alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+) => alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose"}
{"X":40195,"RHEA_ID":38473,"compounds":"3 H(+) + hercynine + 3 S-adenosyl-L-homocysteine => L-histidine + 3 S-adenosyl-L-methionine"}
{"X":40196,"RHEA_ID":48384,"DIRECTION":"UN","MASTER_ID":48384,"ec":"1.11.2.4","compounds":"2,3-saturated fatty acid + H2O2 = 3-hydroxy fatty acid + H2O"}
{"X":40197,"RHEA_ID":38475,"compounds":"L-histidine + S-adenosyl-L-methionine = H(+) + N(alpha)-methyl-L-histidine + S-adenosyl-L-homocysteine"}
{"X":40198,"RHEA_ID":48386,"compounds":"3-hydroxy fatty acid + H2O => 2,3-saturated fatty acid + H2O2"}
{"X":40199,"RHEA_ID":38477,"compounds":"H(+) + N(alpha)-methyl-L-histidine + S-adenosyl-L-homocysteine => L-histidine + S-adenosyl-L-methionine"}
{"X":40200,"RHEA_ID":48388,"compounds":"alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose = alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)"}
{"X":40201,"RHEA_ID":38479,"compounds":"N(alpha)-methyl-L-histidine + S-adenosyl-L-methionine = H(+) + N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-homocysteine"}
{"X":40202,"RHEA_ID":38480,"DIRECTION":"LR","MASTER_ID":38479,"metacyc":"RXN-14437","compounds":"N(alpha)-methyl-L-histidine + S-adenosyl-L-methionine => H(+) + N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-homocysteine"}
{"X":40203,"RHEA_ID":48391,"compounds":"alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose <=> alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)"}
{"X":40204,"RHEA_ID":48392,"compounds":"GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide = GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide"}
{"X":40205,"RHEA_ID":38483,"compounds":"a 2,3-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)"}
{"X":40206,"RHEA_ID":48394,"compounds":"GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide"}
{"X":40207,"RHEA_ID":48395,"compounds":"GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide <=> GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide"}
{"X":40208,"RHEA_ID":38486,"compounds":"a 2,3-diacyl-sn-glycerol + H2O <=> a 2-acylglycerol + a fatty acid + H(+)"}
{"X":40209,"RHEA_ID":38487,"compounds":"1-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+)"}
{"X":40210,"RHEA_ID":48398,"compounds":"1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one + H(+) + S-adenosyl-L-homocysteine => (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + S-adenosyl-L-methionine"}
{"X":40211,"RHEA_ID":38489,"compounds":"(9Z)-octadecenoate + glycerol + H(+) => 1-(9Z-octadecenoyl)-glycerol + H2O"}
{"X":40212,"RHEA_ID":38490,"compounds":"1-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + glycerol + H(+)"}
{"X":40213,"RHEA_ID":38491,"compounds":"2-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+)"}
{"X":40214,"RHEA_ID":38492,"compounds":"2-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + glycerol + H(+)"}
{"X":40215,"RHEA_ID":38493,"compounds":"(9Z)-octadecenoate + glycerol + H(+) => 2-(9Z-octadecenoyl)-glycerol + H2O"}
{"X":40216,"RHEA_ID":38494,"compounds":"2-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + glycerol + H(+)"}
{"X":40217,"RHEA_ID":38495,"compounds":"a triacylglycerol + H2O = a 1,3-diacylglycerol + a fatty acid + H(+)"}
{"X":40218,"RHEA_ID":38496,"compounds":"a triacylglycerol + H2O => a 1,3-diacylglycerol + a fatty acid + H(+)"}
{"X":40219,"RHEA_ID":48407,"compounds":"apo-[EntB isochorismatase/aryl-carrier protein] + CoA <=> adenosine 3',5'-bisphosphate + H(+) + holo-[EntB isochorismatase/aryl-carrier protein]"}
{"X":40220,"RHEA_ID":38498,"compounds":"a triacylglycerol + H2O <=> a 1,3-diacylglycerol + a fatty acid + H(+)"}
{"X":40221,"RHEA_ID":38499,"compounds":"a triacyl-sn-glycerol + H2O = a 2,3-diacyl-sn-glycerol + a fatty acid + H(+)"}
{"X":40222,"RHEA_ID":38500,"compounds":"a triacyl-sn-glycerol + H2O => a 2,3-diacyl-sn-glycerol + a fatty acid + H(+)"}
{"X":40223,"RHEA_ID":48411,"compounds":"apo-[EntF peptidyl-carrier protein] + CoA <=> adenosine 3',5'-bisphosphate + H(+) + holo-[EntF peptidyl-carrier protein]"}
{"X":40224,"RHEA_ID":48412,"compounds":"globoside IV3GalNAc-Gb4Cer + H2O = globoside Gb4Cer + N-acetyl-alpha-D-galactosamine"}
{"X":40225,"RHEA_ID":38503,"compounds":"1,3-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)"}
{"X":40226,"RHEA_ID":38504,"compounds":"1,3-diacyl-sn-glycerol + H2O => a 1-acyl-sn-glycerol + a fatty acid + H(+)"}
{"X":40227,"RHEA_ID":48415,"compounds":"globoside IV3GalNAc-Gb4Cer + H2O <=> globoside Gb4Cer + N-acetyl-alpha-D-galactosamine"}
{"X":40228,"RHEA_ID":48416,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E)) = CMP + ganglioside GM2 (d18:1(4E)) + H(+)"}
{"X":40229,"RHEA_ID":38507,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) + octadecanoate"}
{"X":40230,"RHEA_ID":38508,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) + octadecanoate"}
{"X":40231,"RHEA_ID":48419,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E)) <=> CMP + ganglioside GM2 (d18:1(4E)) + H(+)"}
{"X":40232,"RHEA_ID":48420,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)) = CMP + ganglioside GM1 (d18:1(4E)) + H(+)"}
{"X":40233,"RHEA_ID":38511,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)"}
{"X":40234,"RHEA_ID":38512,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)"}
{"X":40235,"RHEA_ID":48423,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)) <=> CMP + ganglioside GM1 (d18:1(4E)) + H(+)"}
{"X":40236,"RHEA_ID":38514,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)"}
{"X":40237,"RHEA_ID":38515,"compounds":"1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+)"}
{"X":40238,"RHEA_ID":38516,"compounds":"1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O => (9Z)-octadecenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+)"}
{"X":40239,"RHEA_ID":48427,"compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dUMP"}
{"X":40240,"RHEA_ID":48428,"compounds":"1-(9Z,12Z-octadecadienoyl)-glycerol + H2O = (9Z,12Z)-octadecadienoate + glycerol + H(+)"}
{"X":40241,"RHEA_ID":38519,"compounds":"1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 2-octadecanoylglycerol + H(+)"}
{"X":40242,"RHEA_ID":38520,"compounds":"1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 2-octadecanoylglycerol + H(+)"}
{"X":40243,"RHEA_ID":48431,"compounds":"1-(9Z,12Z-octadecadienoyl)-glycerol + H2O <=> (9Z,12Z)-octadecadienoate + glycerol + H(+)"}
{"X":40244,"RHEA_ID":38522,"compounds":"1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 2-octadecanoylglycerol + H(+)"}
{"X":40245,"RHEA_ID":38523,"compounds":"1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z,12Z-octadecadienoyl)-glycerol + H(+)"}
{"X":40246,"RHEA_ID":38524,"compounds":"1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O => (9Z)-octadecenoate + 2-(9Z,12Z-octadecadienoyl)-glycerol + H(+)"}
{"X":40247,"RHEA_ID":38525,"compounds":"(9Z)-octadecenoate + 2-(9Z,12Z-octadecadienoyl)-glycerol + H(+) => 1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O"}
{"X":40248,"RHEA_ID":48436,"compounds":"H2O + pentanoate ester = an aliphatic alcohol + H(+) + pentanoate"}
{"X":40249,"RHEA_ID":38527,"compounds":"1-(9Z-octadecenoyl)-2-O-(5Z,8Z,11Z,14Z-eicosatetraenyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 2-O-(5Z,8Z,11Z,14Z)-eicosatetraenylglycerol + H(+)"}
{"X":40250,"RHEA_ID":38528,"compounds":"1-(9Z-octadecenoyl)-2-O-(5Z,8Z,11Z,14Z-eicosatetraenyl)-sn-glycerol + H2O => (9Z)-octadecenoate + 2-O-(5Z,8Z,11Z,14Z)-eicosatetraenylglycerol + H(+)"}
{"X":40251,"RHEA_ID":38529,"compounds":"(9Z)-octadecenoate + 2-O-(5Z,8Z,11Z,14Z)-eicosatetraenylglycerol + H(+) => 1-(9Z-octadecenoyl)-2-O-(5Z,8Z,11Z,14Z-eicosatetraenyl)-sn-glycerol + H2O"}
{"X":40252,"RHEA_ID":48440,"compounds":"H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol = a fatty acid + H(+) + long chain 2-acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol"}
{"X":40253,"RHEA_ID":38543,"compounds":"H(+) + malonyl-CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein] = (2-aminobenzoyl)acetyl-CoA + CO2 + L-cysteinyl-[PqsD protein]"}
{"X":40254,"RHEA_ID":38544,"DIRECTION":"LR","MASTER_ID":38543,"metacyc":"RXN-17702","compounds":"H(+) + malonyl-CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein] => (2-aminobenzoyl)acetyl-CoA + CO2 + L-cysteinyl-[PqsD protein]"}
{"X":40255,"RHEA_ID":38545,"compounds":"(2-aminobenzoyl)acetyl-CoA + CO2 + L-cysteinyl-[PqsD protein] => H(+) + malonyl-CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein]"}
{"X":40256,"RHEA_ID":58470,"compounds":"2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate => 2 2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 O2"}
{"X":40257,"RHEA_ID":38551,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoate + O2 = (R)-2-hydroxyhexadecanoate + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":40258,"RHEA_ID":38552,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoate + O2 => (R)-2-hydroxyhexadecanoate + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":40259,"RHEA_ID":38553,"compounds":"(R)-2-hydroxyhexadecanoate + 2 [Fe(III)-cytochrome b5] + H2O => 2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoate + O2"}
{"X":40260,"RHEA_ID":48448,"compounds":"H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide = beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetyl-beta-D-galactosamine"}
{"X":40261,"RHEA_ID":38555,"compounds":"an all-trans-retinyl ester + H2O = a fatty acid + all-trans-retinol + H(+)"}
{"X":40262,"RHEA_ID":51815,"compounds":"ATP(in) + CoA(in) + H(+)(out) + tetradecanoate(out) <=> AMP(in) + diphosphate(in) + H(+)(in) + tetradecanoyl-CoA(in)"}
{"X":40263,"RHEA_ID":38557,"compounds":"a fatty acid + all-trans-retinol + H(+) => an all-trans-retinyl ester + H2O"}
{"X":40264,"RHEA_ID":48452,"compounds":"ganglioside GA2 (d18:1(4E)) + H2O = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetyl-beta-D-galactosamine"}
{"X":40265,"RHEA_ID":38559,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + tetracosanoate = (R)-2-hydroxytetracosanoate + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":40266,"RHEA_ID":51819,"compounds":"ATP(in) + CoA(in) + dodecanoate(out) + H(+)(out) <=> AMP(in) + diphosphate(in) + dodecanoyl-CoA(in) + H(+)(in)"}
{"X":40267,"RHEA_ID":38561,"compounds":"(R)-2-hydroxytetracosanoate + 2 [Fe(III)-cytochrome b5] + H2O => 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + tetracosanoate"}
{"X":40268,"RHEA_ID":48456,"compounds":"1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O = 2-octanoyl-3-O-beta-D-galactosyl-sn-glycerol + H(+) + octanoate"}
{"X":40269,"RHEA_ID":38563,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycerol + H2O = 1-O-hexadecyl-sn-glycerol + acetate + H(+)"}
{"X":40270,"RHEA_ID":38564,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycerol + H2O => 1-O-hexadecyl-sn-glycerol + acetate + H(+)"}
{"X":40271,"RHEA_ID":38565,"compounds":"1-O-hexadecyl-sn-glycerol + acetate + H(+) => 1-O-hexadecyl-2-acetyl-sn-glycerol + H2O"}
{"X":40272,"RHEA_ID":38566,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycerol + H2O <=> 1-O-hexadecyl-sn-glycerol + acetate + H(+)"}
{"X":40273,"RHEA_ID":38567,"compounds":"1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + H(+) + phosphate"}
{"X":40274,"RHEA_ID":38568,"compounds":"1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O => 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + H(+) + phosphate"}
{"X":40275,"RHEA_ID":38569,"compounds":"1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + H(+) + phosphate => 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O"}
{"X":40276,"RHEA_ID":38570,"compounds":"1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O <=> 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + H(+) + phosphate"}
{"X":40277,"RHEA_ID":38571,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)"}
{"X":40278,"RHEA_ID":38572,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine(in) => a 1,2-diacyl-sn-glycero-3-phosphocholine(out)"}
{"X":40279,"RHEA_ID":38573,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine(out) => a 1,2-diacyl-sn-glycero-3-phosphocholine(in)"}
{"X":40280,"RHEA_ID":48468,"compounds":"ganglioside GM1b (d18:1(4E)) + H2O = ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate"}
{"X":40281,"RHEA_ID":38575,"compounds":"1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H(+)"}
{"X":40282,"RHEA_ID":38576,"compounds":"1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H(+)"}
{"X":40283,"RHEA_ID":38577,"compounds":"(9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H(+) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O"}
{"X":40284,"RHEA_ID":48472,"compounds":"ganglioside GT1a + H2O = ganglioside GD1a + N-acetylneuraminate"}
{"X":40285,"RHEA_ID":38579,"DIRECTION":"UN","MASTER_ID":38579,"ec":"1.14.14.120","compounds":"dammarenediol-II + O2 + reduced [NADPH--hemoprotein reductase] = (20S)-protopanaxadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":40286,"RHEA_ID":38580,"DIRECTION":"LR","MASTER_ID":38579,"metacyc":"RXN-14975","compounds":"dammarenediol-II + O2 + reduced [NADPH--hemoprotein reductase] => (20S)-protopanaxadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":40287,"RHEA_ID":38581,"compounds":"(20S)-protopanaxadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dammarenediol-II + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":40288,"RHEA_ID":58502,"compounds":"glyoxylate + H2O + NAD(+) + trimethylamine => betaine + H(+) + NADH + O2"}
{"X":40289,"RHEA_ID":38583,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + H(+) + phosphate"}
{"X":40290,"RHEA_ID":38584,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O => a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + H(+) + phosphate"}
{"X":40291,"RHEA_ID":38585,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + H(+) + phosphate => a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O"}
{"X":40292,"RHEA_ID":48480,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + UDP-alpha-D-galactose = 1,2-di-(9Z-octadecenoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP"}
{"X":40293,"RHEA_ID":38587,"DIRECTION":"UN","MASTER_ID":38587,"ec":"2.4.1.310","compounds":"UDP-alpha-D-glucose + vancomycin aglycone = devancoaminyl-vancomycin + UDP"}
{"X":40294,"RHEA_ID":51851,"compounds":"8-methylmenaquinone-6 + succinate <=> 8-methylmenaquinol-6 + fumarate"}
{"X":40295,"RHEA_ID":38589,"compounds":"devancoaminyl-vancomycin + UDP => UDP-alpha-D-glucose + vancomycin aglycone"}
{"X":40296,"RHEA_ID":48484,"compounds":"a propanoate ester + H2O = an aliphatic alcohol + H(+) + propanoate"}
{"X":40297,"RHEA_ID":38591,"DIRECTION":"UN","MASTER_ID":38591,"ec":"2.4.1.311","compounds":"devancoaminyl-vancomycin + dTDP-beta-L-4-epi-vancosamine = chloroorienticin B + dTDP + H(+)"}
{"X":40298,"RHEA_ID":38592,"compounds":"devancoaminyl-vancomycin + dTDP-beta-L-4-epi-vancosamine => chloroorienticin B + dTDP + H(+)"}
{"X":40299,"RHEA_ID":38593,"compounds":"chloroorienticin B + dTDP + H(+) => devancoaminyl-vancomycin + dTDP-beta-L-4-epi-vancosamine"}
{"X":40300,"RHEA_ID":58514,"compounds":"1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+) => 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH"}
{"X":40301,"RHEA_ID":38595,"compounds":"1,3-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+)"}
{"X":40302,"RHEA_ID":38596,"compounds":"1,3-di-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+)"}
{"X":40303,"RHEA_ID":38597,"compounds":"(9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+) => 1,3-di-(9Z-octadecenoyl)-glycerol + H2O"}
{"X":40304,"RHEA_ID":38598,"compounds":"1,3-di-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+)"}
{"X":40305,"RHEA_ID":48493,"compounds":"1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + UDP-alpha-D-galactose => 1,2-di-(9Z,12Z-octadecadienoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP"}
{"X":40306,"RHEA_ID":38600,"DIRECTION":"LR","MASTER_ID":38599,"metacyc":"RXN-13972","compounds":"NADP(+) + nicotinate => nicotinamide + nicotinate-adenine dinucleotide phosphate"}
{"X":40307,"RHEA_ID":38601,"compounds":"nicotinamide + nicotinate-adenine dinucleotide phosphate => NADP(+) + nicotinate"}
{"X":40308,"RHEA_ID":48496,"compounds":"1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + UDP-alpha-D-galactose = 1-(9Z-octadecenoyl)-2-hexadecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP"}
{"X":40309,"RHEA_ID":48497,"compounds":"1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + UDP-alpha-D-galactose => 1-(9Z-octadecenoyl)-2-hexadecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP"}
{"X":40310,"RHEA_ID":38604,"DIRECTION":"LR","MASTER_ID":38603,"metacyc":"RXN-13971","compounds":"NADP(+) => 2'-phospho-cyclic ADP-ribose + nicotinamide"}
{"X":40311,"RHEA_ID":38605,"compounds":"2'-phospho-cyclic ADP-ribose + nicotinamide => NADP(+)"}
{"X":40312,"RHEA_ID":48500,"compounds":"H2O + octanoylglycerol = glycerol + H(+) + octanoate"}
{"X":40313,"RHEA_ID":48501,"compounds":"H2O + octanoylglycerol => glycerol + H(+) + octanoate"}
{"X":40314,"RHEA_ID":38608,"DIRECTION":"LR","MASTER_ID":38607,"metacyc":"RXN-13972","compounds":"2'-phospho-cyclic ADP-ribose + nicotinate => nicotinate-adenine dinucleotide phosphate"}
{"X":40315,"RHEA_ID":38609,"compounds":"nicotinate-adenine dinucleotide phosphate => 2'-phospho-cyclic ADP-ribose + nicotinate"}
{"X":40316,"RHEA_ID":48504,"compounds":"D-glycero-D-manno-heptose 1,7-bisphosphate + H2O = D-glycero-D-manno-heptose 1-phosphate + phosphate"}
{"X":40317,"RHEA_ID":48505,"compounds":"D-glycero-D-manno-heptose 1,7-bisphosphate + H2O => D-glycero-D-manno-heptose 1-phosphate + phosphate"}
{"X":40318,"RHEA_ID":38612,"compounds":"NAD(+) => cyclic ADP-ribose + H(+) + nicotinamide"}
{"X":40319,"RHEA_ID":38613,"compounds":"cyclic ADP-ribose + H(+) + nicotinamide => NAD(+)"}
{"X":40320,"RHEA_ID":48508,"compounds":"cholate + NADP(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH"}
{"X":40321,"RHEA_ID":38615,"compounds":"cyclic ADP-ribose + H2O = ADP-D-ribose"}
{"X":40322,"RHEA_ID":38616,"compounds":"cyclic ADP-ribose + H2O => ADP-D-ribose"}
{"X":40323,"RHEA_ID":38617,"compounds":"ADP-D-ribose => cyclic ADP-ribose + H2O"}
{"X":40324,"RHEA_ID":48512,"compounds":"ATP + H2O + phosphinate(out) = ADP + H(+) + phosphate + phosphinate(in)"}
{"X":40325,"RHEA_ID":48513,"compounds":"ATP + H2O + phosphinate(out) => ADP + H(+) + phosphate + phosphinate(in)"}
{"X":40326,"RHEA_ID":38620,"DIRECTION":"LR","MASTER_ID":38619,"metacyc":"RXN-14701","compounds":"nicotinate beta-D-ribonucleotide + phenol => H(+) + nicotinate + phenyl 5-phospho-alpha-D-ribofuranoside"}
{"X":40327,"RHEA_ID":38621,"compounds":"H(+) + nicotinate + phenyl 5-phospho-alpha-D-ribofuranoside => nicotinate beta-D-ribonucleotide + phenol"}
{"X":40328,"RHEA_ID":48516,"compounds":"1,2-didodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = dodecanoate + dodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+)"}
{"X":40329,"RHEA_ID":48517,"compounds":"1,2-didodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O => dodecanoate + dodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+)"}
{"X":40330,"RHEA_ID":38624,"compounds":"1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-octanoyl-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":40331,"RHEA_ID":38625,"compounds":"1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-octanoyl-sn-glycero-3-phospho]-glycerol + CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA"}
{"X":40332,"RHEA_ID":38626,"compounds":"1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-octanoyl-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":40333,"RHEA_ID":48521,"DIRECTION":"LR","MASTER_ID":48520,"metacyc":"RXN-8409","compounds":"[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + H2O => [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + H(+) + methanol"}
{"X":40334,"RHEA_ID":38628,"compounds":"1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA => 1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":40335,"RHEA_ID":38630,"compounds":"1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA <=> 1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":40336,"RHEA_ID":38631,"compounds":"1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":40337,"RHEA_ID":38632,"compounds":"1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":40338,"RHEA_ID":48527,"compounds":"ganglioside GP1c + H2O <=> ganglioside GQ1c + N-acetylneuraminate"}
{"X":40339,"RHEA_ID":38634,"compounds":"1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":40340,"RHEA_ID":48529,"compounds":"ganglioside GP1c (d18:1(4E)) + H2O => ganglioside GQ1c (d18:1(4E)) + N-acetylneuraminate"}
{"X":40341,"RHEA_ID":38636,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":40342,"RHEA_ID":38637,"compounds":"1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho]-glycerol + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol"}
{"X":40343,"RHEA_ID":38638,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":40344,"RHEA_ID":48533,"compounds":"ganglioside GQ1c (d18:1(4E)) + H2O => ganglioside GT1c (d18:1(4E)) + N-acetylneuraminate"}
{"X":40345,"RHEA_ID":38640,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol => 1'-[1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":40346,"RHEA_ID":38641,"compounds":"1'-[1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol"}
{"X":40347,"RHEA_ID":38642,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol <=> 1'-[1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":40348,"RHEA_ID":38643,"compounds":"1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+)"}
{"X":40349,"RHEA_ID":38644,"compounds":"1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+)"}
{"X":40350,"RHEA_ID":38645,"compounds":"(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+) => 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O"}
{"X":40351,"RHEA_ID":38646,"compounds":"1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+)"}
{"X":40352,"RHEA_ID":38647,"compounds":"1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+)"}
{"X":40353,"RHEA_ID":38648,"compounds":"1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+)"}
{"X":40354,"RHEA_ID":48543,"compounds":"1,2-didodecanoyl-3-beta-D-galactosyl-sn-glycerol + H2O <=> dodecanoate + dodecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+)"}
{"X":40355,"RHEA_ID":38650,"compounds":"1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+)"}
{"X":40356,"RHEA_ID":38651,"compounds":"1,3-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+)"}
{"X":40357,"RHEA_ID":38652,"compounds":"1,3-di-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+)"}
{"X":40358,"RHEA_ID":38653,"compounds":"(9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+) => 1,3-di-(9Z-octadecenoyl)-glycerol + H2O"}
{"X":40359,"RHEA_ID":38654,"compounds":"1,3-di-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+)"}
{"X":40360,"RHEA_ID":38655,"DIRECTION":"UN","MASTER_ID":38655,"ec":"4.2.99.23","compounds":"6-tuliposide B = D-glucose + tulipalin B"}
{"X":40361,"RHEA_ID":38656,"compounds":"6-tuliposide B => D-glucose + tulipalin B"}
{"X":40362,"RHEA_ID":48551,"compounds":"[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O <=> [phosphatase 2A protein]-C-terminal L-leucine + H(+) + methanol"}
{"X":40363,"RHEA_ID":48552,"compounds":"1-(9S,13S-12-oxo-10,15Z-phytodienoyl)-2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O = (10Z,15Z)-12-oxophytodienoate + 2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+)"}
{"X":40364,"RHEA_ID":38659,"compounds":"1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)"}
{"X":40365,"RHEA_ID":48554,"compounds":"(10Z,15Z)-12-oxophytodienoate + 2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) => 1-(9S,13S-12-oxo-10,15Z-phytodienoyl)-2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O"}
{"X":40366,"RHEA_ID":38661,"compounds":"(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+) => 1,2-di-(9Z-octadecenoyl)-glycerol + H2O"}
{"X":40367,"RHEA_ID":38662,"compounds":"1,2-di-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)"}
{"X":40368,"RHEA_ID":38663,"compounds":"1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)"}
{"X":40369,"RHEA_ID":48558,"compounds":"4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate => 4-hydroxybenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+)"}
{"X":40370,"RHEA_ID":58585,"compounds":"dihydroprecondylocarpine acetate => (-)-tabersonine + acetate + H(+)"}
{"X":40371,"RHEA_ID":38666,"compounds":"1,2-diacyl-sn-glycero-3-phospho-L-serine(in) <=> 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)"}
{"X":40372,"RHEA_ID":38667,"compounds":"sphing-4-enine 1-phosphate(in) = sphing-4-enine 1-phosphate(out)"}
{"X":40373,"RHEA_ID":48562,"compounds":"D-ribose 5-phosphate + N(6)-dimethylallyladenine => H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate"}
{"X":40374,"RHEA_ID":38669,"compounds":"sphing-4-enine 1-phosphate(out) => sphing-4-enine 1-phosphate(in)"}
{"X":40375,"RHEA_ID":38670,"compounds":"sphing-4-enine 1-phosphate(in) <=> sphing-4-enine 1-phosphate(out)"}
{"X":40376,"RHEA_ID":38671,"compounds":"sphinganine 1-phosphate(in) = sphinganine 1-phosphate(out)"}
{"X":40377,"RHEA_ID":48566,"compounds":"D-ribose 5-phosphate + trans-zeatin => 9-ribosyl-trans-zeatin 5'-phosphate + H2O"}
{"X":40378,"RHEA_ID":38673,"compounds":"sphinganine 1-phosphate(out) => sphinganine 1-phosphate(in)"}
{"X":40379,"RHEA_ID":38674,"compounds":"sphinganine 1-phosphate(in) <=> sphinganine 1-phosphate(out)"}
{"X":40380,"RHEA_ID":38675,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate"}
{"X":40381,"RHEA_ID":48570,"compounds":"(2E,4Z)-2-chloromuconate + 2 H(+) => 3-chlorocatechol + O2"}
{"X":40382,"RHEA_ID":38677,"compounds":"(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2"}
{"X":40383,"RHEA_ID":58602,"compounds":"H2O + 2 monodehydro-L-ascorbate radical + N-(9Z-octadecenoyl)-(2S)-hydroxyglycine => 2 L-ascorbate + N-(9Z-octadecenoyl)glycine + O2"}
{"X":40384,"RHEA_ID":38679,"compounds":"ATP + H2O + sphinganine(in) = ADP + H(+) + phosphate + sphinganine(out)"}
{"X":40385,"RHEA_ID":48574,"compounds":"(2E,4E)-2,4-dichloromuconate + 2 H(+) => 3,5-dichlorocatechol + O2"}
{"X":40386,"RHEA_ID":38681,"compounds":"ADP + H(+) + phosphate + sphinganine(out) => ATP + H2O + sphinganine(in)"}
{"X":40387,"RHEA_ID":48576,"compounds":"4-chlorocatechol + O2 = 3-chloro-cis,cis-muconate + 2 H(+)"}
{"X":40388,"RHEA_ID":38683,"compounds":"ATP + H2O + sphing-4-enine(in) = ADP + H(+) + phosphate + sphing-4-enine(out)"}
{"X":40389,"RHEA_ID":48578,"compounds":"3-chloro-cis,cis-muconate + 2 H(+) => 4-chlorocatechol + O2"}
{"X":40390,"RHEA_ID":38685,"compounds":"ADP + H(+) + phosphate + sphing-4-enine(out) => ATP + H2O + sphing-4-enine(in)"}
{"X":40391,"RHEA_ID":38686,"compounds":"ATP + H2O + sphing-4-enine(in) <=> ADP + H(+) + phosphate + sphing-4-enine(out)"}
{"X":40392,"RHEA_ID":38687,"compounds":"4-hydroxysphinganine(in) + ATP + H2O = 4-hydroxysphinganine(out) + ADP + H(+) + phosphate"}
{"X":40393,"RHEA_ID":48582,"compounds":"[pyruvate, water dikinase] + diphosphate => [pyruvate, water dikinase]-phosphate + H(+) + phosphate"}
{"X":40394,"RHEA_ID":38689,"compounds":"4-hydroxysphinganine(out) + ADP + H(+) + phosphate => 4-hydroxysphinganine(in) + ATP + H2O"}
{"X":40395,"RHEA_ID":38690,"compounds":"4-hydroxysphinganine(in) + ATP + H2O <=> 4-hydroxysphinganine(out) + ADP + H(+) + phosphate"}
{"X":40396,"RHEA_ID":38691,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)"}
{"X":40397,"RHEA_ID":48586,"compounds":"2 lipoxin A4 => 2 H2O + 2 leukotriene A4 + O2"}
{"X":40398,"RHEA_ID":38693,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in)"}
{"X":40399,"RHEA_ID":38694,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)"}
{"X":40400,"RHEA_ID":38695,"compounds":"a cardiolipin(in) = a cardiolipin(out)"}
{"X":40401,"RHEA_ID":38696,"compounds":"a cardiolipin(in) => a cardiolipin(out)"}
{"X":40402,"RHEA_ID":38697,"compounds":"a cardiolipin(out) => a cardiolipin(in)"}
{"X":40403,"RHEA_ID":38698,"compounds":"a cardiolipin(in) <=> a cardiolipin(out)"}
{"X":40404,"RHEA_ID":38699,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)"}
{"X":40405,"RHEA_ID":48594,"compounds":"a quinol + CO2 => a quinone + formate + H(+)"}
{"X":40406,"RHEA_ID":38701,"compounds":"(9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O"}
{"X":40407,"RHEA_ID":38702,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)"}
{"X":40408,"RHEA_ID":38703,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}
{"X":40409,"RHEA_ID":38704,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}
{"X":40410,"RHEA_ID":38705,"compounds":"1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}
{"X":40411,"RHEA_ID":38706,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}
{"X":40412,"RHEA_ID":38707,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol"}
{"X":40413,"RHEA_ID":48602,"compounds":"[protein-PII]-L-tyrosine + H(+) + UMP => [protein-PII]-uridylyl-L-tyrosine + H2O"}
{"X":40414,"RHEA_ID":38709,"compounds":"(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-sn-glycerol"}
{"X":40415,"RHEA_ID":38710,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-sn-glycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol"}
{"X":40416,"RHEA_ID":38711,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecylglycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-3-(9Z)-octadecenoylglycerol"}
{"X":40417,"RHEA_ID":48606,"compounds":"2,3-dihydroxybenzoyl-[EntB isochorismatase/aryl-carrier protein] + AMP + H(+) => 2,3-dihydroxybenzoyl-5'-AMP + holo-[EntB isochorismatase/aryl-carrier protein]"}
{"X":40418,"RHEA_ID":38713,"compounds":"(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-3-(9Z)-octadecenoylglycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecylglycerol"}
{"X":40419,"RHEA_ID":38714,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecylglycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-3-(9Z)-octadecenoylglycerol"}
{"X":40420,"RHEA_ID":38715,"compounds":"ATP + choline(out) + H2O = ADP + choline(in) + H(+) + phosphate"}
{"X":40421,"RHEA_ID":48610,"compounds":"a 2,3-dehydroacyl-CoA + AH2 => A + a 2,3-saturated acyl-CoA"}
{"X":40422,"RHEA_ID":38717,"compounds":"ADP + choline(in) + H(+) + phosphate => ATP + choline(out) + H2O"}
{"X":40423,"RHEA_ID":38718,"compounds":"ATP + choline(out) + H2O <=> ADP + choline(in) + H(+) + phosphate"}
{"X":40424,"RHEA_ID":38719,"compounds":"(R)-carnitine(out) + ATP + H2O = (R)-carnitine(in) + ADP + H(+) + phosphate"}
{"X":40425,"RHEA_ID":38720,"compounds":"(R)-carnitine(out) + ATP + H2O => (R)-carnitine(in) + ADP + H(+) + phosphate"}
{"X":40426,"RHEA_ID":38721,"compounds":"(R)-carnitine(in) + ADP + H(+) + phosphate => (R)-carnitine(out) + ATP + H2O"}
{"X":40427,"RHEA_ID":38722,"compounds":"(R)-carnitine(out) + ATP + H2O <=> (R)-carnitine(in) + ADP + H(+) + phosphate"}
{"X":40428,"RHEA_ID":38723,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-3-(9Z)-octadecenoyl-sn-glycerol"}
{"X":40429,"RHEA_ID":48618,"compounds":"glycine + leukotriene E4 => H2O + leukotriene D4"}
{"X":40430,"RHEA_ID":38725,"compounds":"(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-3-(9Z)-octadecenoyl-sn-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-sn-glycerol"}
{"X":40431,"RHEA_ID":38726,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-sn-glycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-3-(9Z)-octadecenoyl-sn-glycerol"}
{"X":40432,"RHEA_ID":38727,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol"}
{"X":40433,"RHEA_ID":48622,"compounds":"(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O => (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione"}
{"X":40434,"RHEA_ID":38729,"compounds":"(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycerol"}
{"X":40435,"RHEA_ID":38730,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol"}
{"X":40436,"RHEA_ID":38731,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-hexadecanoyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol"}
{"X":40437,"RHEA_ID":48626,"compounds":"(5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate => (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + O2"}
{"X":40438,"RHEA_ID":38733,"compounds":"(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-hexadecanoyl-sn-glycerol"}
{"X":40439,"RHEA_ID":38734,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-hexadecanoyl-sn-glycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol"}
{"X":40440,"RHEA_ID":38735,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-hexadecanoylglycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-2-hexadecanoylglycerol"}
{"X":40441,"RHEA_ID":48630,"compounds":"a 2'-O-methylribonucleotide in rRNA + H(+) + S-adenosyl-L-homocysteine => a ribonucleotide in rRNA + S-adenosyl-L-methionine"}
{"X":40442,"RHEA_ID":38737,"compounds":"(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-2-hexadecanoylglycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-hexadecanoylglycerol"}
{"X":40443,"RHEA_ID":38738,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-hexadecanoylglycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-2-hexadecanoylglycerol"}
{"X":40444,"RHEA_ID":38739,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol"}
{"X":40445,"RHEA_ID":48634,"compounds":"5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoate + H2O => (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate"}
{"X":40446,"RHEA_ID":38741,"compounds":"(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol"}
{"X":40447,"RHEA_ID":38742,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol"}
{"X":40448,"RHEA_ID":38743,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-(9Z-octadecenoyl)-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol"}
{"X":40449,"RHEA_ID":48638,"compounds":"15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate"}
{"X":40450,"RHEA_ID":38745,"compounds":"(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-(9Z-octadecenoyl)-sn-glycerol"}
{"X":40451,"RHEA_ID":38746,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-(9Z-octadecenoyl)-sn-glycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol"}
{"X":40452,"RHEA_ID":38747,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(9Z-octadecenoyl) ethanolamine = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(9Z)-octadecenoylamino]ethyl (9Z)-octadecenoate"}
{"X":40453,"RHEA_ID":38748,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(9Z-octadecenoyl) ethanolamine => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(9Z)-octadecenoylamino]ethyl (9Z)-octadecenoate"}
{"X":40454,"RHEA_ID":38749,"compounds":"(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(9Z)-octadecenoylamino]ethyl (9Z)-octadecenoate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(9Z-octadecenoyl) ethanolamine"}
{"X":40455,"RHEA_ID":38750,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(9Z-octadecenoyl) ethanolamine <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(9Z)-octadecenoylamino]ethyl (9Z)-octadecenoate"}
{"X":40456,"RHEA_ID":38751,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(5Z,8Z,11Z,14Z)-eicosatetraenoylamino]ethyl (9Z)-octadecenoate"}
{"X":40457,"RHEA_ID":38752,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(5Z,8Z,11Z,14Z)-eicosatetraenoylamino]ethyl (9Z)-octadecenoate"}
{"X":40458,"RHEA_ID":38753,"compounds":"(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(5Z,8Z,11Z,14Z)-eicosatetraenoylamino]ethyl (9Z)-octadecenoate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine"}
{"X":40459,"RHEA_ID":38754,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(5Z,8Z,11Z,14Z)-eicosatetraenoylamino]ethyl (9Z)-octadecenoate"}
{"X":40460,"RHEA_ID":38755,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":40461,"RHEA_ID":38756,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":40462,"RHEA_ID":38757,"compounds":"1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}
{"X":40463,"RHEA_ID":38758,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":40464,"RHEA_ID":38759,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}
{"X":40465,"RHEA_ID":48654,"compounds":"20-hydroxy-lipoxin B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => lipoxin B4 + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":40466,"RHEA_ID":38761,"compounds":"1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}
{"X":40467,"RHEA_ID":38762,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}
{"X":40468,"RHEA_ID":38763,"compounds":"1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}
{"X":40469,"RHEA_ID":38764,"compounds":"1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}
{"X":40470,"RHEA_ID":48659,"compounds":"5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 5,20-dihydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":40471,"RHEA_ID":38766,"compounds":"1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}
{"X":40472,"RHEA_ID":38767,"compounds":"1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":40473,"RHEA_ID":38768,"compounds":"1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":40474,"RHEA_ID":48663,"compounds":"8-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8,20-dihydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":40475,"RHEA_ID":38770,"compounds":"1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":40476,"RHEA_ID":38771,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":40477,"RHEA_ID":38772,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":40478,"RHEA_ID":38773,"compounds":"1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}
{"X":40479,"RHEA_ID":48668,"compounds":"20-hydroxy-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-oxo-leukotriene B4 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":40480,"RHEA_ID":38775,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine"}
{"X":40481,"RHEA_ID":38776,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine"}
{"X":40482,"RHEA_ID":38777,"compounds":"1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}
{"X":40483,"RHEA_ID":48672,"compounds":"20-oxo-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-carboxy-leukotriene B4 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":40484,"RHEA_ID":38779,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":40485,"RHEA_ID":38780,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":40486,"RHEA_ID":38781,"compounds":"(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O"}
{"X":40487,"RHEA_ID":48676,"compounds":"6-trans-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-6-trans-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":40488,"RHEA_ID":38783,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":40489,"RHEA_ID":38784,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":40490,"RHEA_ID":38785,"compounds":"2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O"}
{"X":40491,"RHEA_ID":48680,"DIRECTION":"UN","MASTER_ID":48680,"ec":"1.1.1.330","compounds":"a very-long-chain (3R)-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH"}
{"X":40492,"RHEA_ID":38787,"compounds":"1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":40493,"RHEA_ID":38788,"compounds":"1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":40494,"RHEA_ID":38789,"compounds":"(9Z)-octadecenoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":40495,"RHEA_ID":48684,"DIRECTION":"UN","MASTER_ID":48684,"ec":"3.5.1.130","compounds":"[amino group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O = [amino group carrier protein]-C-terminal-L-glutamate + L-lysine"}
{"X":40496,"RHEA_ID":38791,"compounds":"1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-octadecanoyl-sn-glycero-3-phosphocholine"}
{"X":40497,"RHEA_ID":38792,"compounds":"1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-octadecanoyl-sn-glycero-3-phosphocholine"}
{"X":40498,"RHEA_ID":38793,"compounds":"1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-octadecanoyl-sn-glycero-3-phosphocholine => 1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}
{"X":40499,"RHEA_ID":38794,"compounds":"1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-octadecanoyl-sn-glycero-3-phosphocholine"}
{"X":40500,"RHEA_ID":38795,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine"}
{"X":40501,"RHEA_ID":38796,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine"}
{"X":40502,"RHEA_ID":38797,"compounds":"1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}
{"X":40503,"RHEA_ID":48692,"compounds":"1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = H(+) + octanoate + octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol"}
{"X":40504,"RHEA_ID":38799,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}
{"X":40505,"RHEA_ID":38800,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}
{"X":40506,"RHEA_ID":38801,"compounds":"1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}
{"X":40507,"RHEA_ID":48696,"compounds":"1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O = H(+) + octanoate + octanoyl-3-(beta-D-galactosyl)-sn-glycerol"}
{"X":40508,"RHEA_ID":48697,"compounds":"1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O => H(+) + octanoate + octanoyl-3-(beta-D-galactosyl)-sn-glycerol"}
{"X":40509,"RHEA_ID":38804,"compounds":"1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-octadecanoyl-N-(acetyl)-sphing-4-enine + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}
{"X":40510,"RHEA_ID":38805,"compounds":"1-octadecanoyl-N-(acetyl)-sphing-4-enine + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}
{"X":40511,"RHEA_ID":38806,"compounds":"1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-octadecanoyl-N-(acetyl)-sphing-4-enine + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}
{"X":40512,"RHEA_ID":48701,"compounds":"H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol => a fatty acid + H(+) + long chain acyl-3-O-beta-D-galactosyl-sn-glycerol"}
{"X":40513,"RHEA_ID":38808,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":40514,"RHEA_ID":38809,"compounds":"1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}
{"X":40515,"RHEA_ID":48704,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = 12S-HpEPE"}
{"X":40516,"RHEA_ID":48705,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 => 12S-HpEPE"}
{"X":40517,"RHEA_ID":38812,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine"}
{"X":40518,"RHEA_ID":38813,"compounds":"1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}
{"X":40519,"RHEA_ID":48708,"compounds":"H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol = a fatty acid + H(+) + long chain acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol"}
{"X":40520,"RHEA_ID":38815,"compounds":"1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine"}
{"X":40521,"RHEA_ID":38816,"compounds":"1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine"}
{"X":40522,"RHEA_ID":38817,"compounds":"1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}
{"X":40523,"RHEA_ID":38818,"compounds":"1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine"}
{"X":40524,"RHEA_ID":38819,"compounds":"1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":40525,"RHEA_ID":38820,"compounds":"1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":40526,"RHEA_ID":38821,"compounds":"1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}
{"X":40527,"RHEA_ID":48716,"compounds":"(13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 13-oxo-(9Z,11E)-octadecadienoate + H2O"}
{"X":40528,"RHEA_ID":38823,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":40529,"RHEA_ID":38824,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":40530,"RHEA_ID":38825,"compounds":"1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine"}
{"X":40531,"RHEA_ID":48720,"DIRECTION":"UN","MASTER_ID":48720,"ec":"1.1.1.394","compounds":"aurachin B + H2O + NAD(+) = 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NADH"}
{"X":40532,"RHEA_ID":38827,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":40533,"RHEA_ID":38828,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":40534,"RHEA_ID":38829,"compounds":"1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine"}
{"X":40535,"RHEA_ID":38830,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":40536,"RHEA_ID":38831,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine"}
{"X":40537,"RHEA_ID":38832,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine"}
{"X":40538,"RHEA_ID":38833,"compounds":"1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine"}
{"X":40539,"RHEA_ID":48728,"compounds":"3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NAD(+) = 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H(+) + NADH"}
{"X":40540,"RHEA_ID":38835,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":40541,"RHEA_ID":38836,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":40542,"RHEA_ID":38837,"compounds":"1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine"}
{"X":40543,"RHEA_ID":38838,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":40544,"RHEA_ID":38839,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":40545,"RHEA_ID":52107,"compounds":"a beta-D-galactoside + CMP-N-acetyl-beta-neuraminate <=> an N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H(+)"}
{"X":40546,"RHEA_ID":38841,"compounds":"1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine"}
{"X":40547,"RHEA_ID":38842,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":40548,"RHEA_ID":48737,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":40549,"RHEA_ID":38844,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine"}
{"X":40550,"RHEA_ID":38845,"compounds":"1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine"}
{"X":40551,"RHEA_ID":38846,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine"}
{"X":40552,"RHEA_ID":48741,"DIRECTION":"LR","MASTER_ID":48740,"metacyc":"RXN-14566","compounds":"[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + O-phospho-L-serine => [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + phosphate"}
{"X":40553,"RHEA_ID":38848,"compounds":"1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":40554,"RHEA_ID":38849,"compounds":"a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":40555,"RHEA_ID":38850,"compounds":"1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":40556,"RHEA_ID":48745,"DIRECTION":"LR","MASTER_ID":48744,"metacyc":"RXN-16344","compounds":"(-)-yatein + 2-oxoglutarate + O2 => (-)-deoxypodophyllotoxin + CO2 + H2O + succinate"}
{"X":40557,"RHEA_ID":38852,"DIRECTION":"LR","MASTER_ID":38851,"metacyc":"RXN-15056","compounds":"H(+) + tetracenomycin F2 => H2O + tetracenomycin F1"}
{"X":40558,"RHEA_ID":38853,"compounds":"H2O + tetracenomycin F1 => H(+) + tetracenomycin F2"}
{"X":40559,"RHEA_ID":48748,"DIRECTION":"UN","MASTER_ID":48748,"ec":"1.1.1.403","compounds":"D-threitol + NAD(+) = D-erythrulose + H(+) + NADH"}
{"X":40560,"RHEA_ID":48749,"compounds":"D-threitol + NAD(+) => D-erythrulose + H(+) + NADH"}
{"X":40561,"RHEA_ID":38856,"compounds":"2 [Fe(II)-cytochrome b5] + a 1,2-saturated fatty acid + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a (R)-2-hydroxy fatty acid + H2O"}
{"X":40562,"RHEA_ID":38857,"compounds":"2 [Fe(III)-cytochrome b5] + a (R)-2-hydroxy fatty acid + H2O => 2 [Fe(II)-cytochrome b5] + a 1,2-saturated fatty acid + 2 H(+) + O2"}
{"X":40563,"RHEA_ID":38858,"compounds":"2 [Fe(II)-cytochrome b5] + a 1,2-saturated fatty acid + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a (R)-2-hydroxy fatty acid + H2O"}
{"X":40564,"RHEA_ID":48753,"DIRECTION":"LR","MASTER_ID":48752,"metacyc":"RXN-17381","compounds":"2-oxoglutarate + O2 + validamycin A => CO2 + H(+) + succinate + validamycin B"}
{"X":40565,"RHEA_ID":38860,"DIRECTION":"LR","MASTER_ID":38859,"metacyc":"RXN-8476","compounds":"beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP-alpha-D-glucose => bis(beta-D-gentiobiosyl) crocetin + H(+) + UDP"}
{"X":40566,"RHEA_ID":38861,"compounds":"bis(beta-D-gentiobiosyl) crocetin + H(+) + UDP => beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP-alpha-D-glucose"}
{"X":40567,"RHEA_ID":48756,"compounds":"erythritol + NAD(+) = D-erythrulose + H(+) + NADH"}
{"X":40568,"RHEA_ID":48757,"compounds":"erythritol + NAD(+) => D-erythrulose + H(+) + NADH"}
{"X":40569,"RHEA_ID":38864,"compounds":"phosphate + sucrose 6(F)-phosphate => alpha-D-glucose 1-phosphate + beta-D-fructose 6-phosphate"}
{"X":40570,"RHEA_ID":38865,"compounds":"alpha-D-glucose 1-phosphate + beta-D-fructose 6-phosphate => phosphate + sucrose 6(F)-phosphate"}
{"X":40571,"RHEA_ID":38866,"DIRECTION":"BI","MASTER_ID":38863,"metacyc":"RXN-15605","compounds":"phosphate + sucrose 6(F)-phosphate <=> alpha-D-glucose 1-phosphate + beta-D-fructose 6-phosphate"}
{"X":40572,"RHEA_ID":38867,"DIRECTION":"UN","MASTER_ID":38867,"ec":"5.4.99.19","compounds":"uridine(516) in 16S rRNA = pseudouridine(516) in 16S rRNA"}
{"X":40573,"RHEA_ID":38868,"DIRECTION":"LR","MASTER_ID":38867,"ecocyc":"RXN-11833","metacyc":"RXN-11833","compounds":"uridine(516) in 16S rRNA => pseudouridine(516) in 16S rRNA"}
{"X":40574,"RHEA_ID":38869,"compounds":"pseudouridine(516) in 16S rRNA => uridine(516) in 16S rRNA"}
{"X":40575,"RHEA_ID":38870,"compounds":"uridine(516) in 16S rRNA <=> pseudouridine(516) in 16S rRNA"}
{"X":40576,"RHEA_ID":48765,"DIRECTION":"LR","MASTER_ID":48764,"metacyc":"RXN-17424","compounds":"3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + NAD(+) => 3-acetyl-3-devinylchlorophyllide a + H(+) + NADH"}
{"X":40577,"RHEA_ID":48766,"compounds":"3-acetyl-3-devinylchlorophyllide a + H(+) + NADH => 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + NAD(+)"}
{"X":40578,"RHEA_ID":38873,"compounds":"pseudouridine(2457) in 23S rRNA => 23S rRNA uridine(2457)"}
{"X":40579,"RHEA_ID":38874,"compounds":"23S rRNA uridine(2457) <=> pseudouridine(2457) in 23S rRNA"}
{"X":40580,"RHEA_ID":38875,"DIRECTION":"UN","MASTER_ID":38875,"ec":"5.4.99.21","compounds":"23S rRNA uridine(2604) = pseudouridine(2604) in 23S rRNA"}
{"X":40581,"RHEA_ID":38876,"DIRECTION":"LR","MASTER_ID":38875,"ecocyc":"RXN-11835","metacyc":"RXN-11835","compounds":"23S rRNA uridine(2604) => pseudouridine(2604) in 23S rRNA"}
{"X":40582,"RHEA_ID":38877,"compounds":"pseudouridine(2604) in 23S rRNA => 23S rRNA uridine(2604)"}
{"X":40583,"RHEA_ID":38878,"compounds":"23S rRNA uridine(2604) <=> pseudouridine(2604) in 23S rRNA"}
{"X":40584,"RHEA_ID":38879,"compounds":"a fatty acid(in) = a fatty acid(out)"}
{"X":40585,"RHEA_ID":48774,"DIRECTION":"RL","MASTER_ID":48772,"metacyc":"RXN-8793","compounds":"3-deacetyl-3-vinylbacteriochlorophyllide a + H2O => 3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a"}
{"X":40586,"RHEA_ID":38881,"compounds":"a fatty acid(out) => a fatty acid(in)"}
{"X":40587,"RHEA_ID":38882,"compounds":"a fatty acid(in) <=> a fatty acid(out)"}
{"X":40588,"RHEA_ID":38883,"compounds":"a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate"}
{"X":40589,"RHEA_ID":38884,"compounds":"a fatty acid + ATP + CoA => a fatty acyl-CoA + AMP + diphosphate"}
{"X":40590,"RHEA_ID":38885,"compounds":"a fatty acyl-CoA + AMP + diphosphate => a fatty acid + ATP + CoA"}
{"X":40591,"RHEA_ID":38886,"compounds":"a fatty acid + ATP + CoA <=> a fatty acyl-CoA + AMP + diphosphate"}
{"X":40592,"RHEA_ID":38887,"compounds":"H2O + N-hexanoyl-sphinganine = hexanoate + sphinganine"}
{"X":40593,"RHEA_ID":48782,"compounds":"ADP + H(+) + L-erythrulose 1-phosphate => ATP + L-erythrulose"}
{"X":40594,"RHEA_ID":38889,"compounds":"hexanoate + sphinganine => H2O + N-hexanoyl-sphinganine"}
{"X":40595,"RHEA_ID":38890,"compounds":"H2O + N-hexanoyl-sphinganine <=> hexanoate + sphinganine"}
{"X":40596,"RHEA_ID":38891,"compounds":"H2O + N-hexadecanoylsphing-4-enine = hexadecanoate + sphing-4-enine"}
{"X":40597,"RHEA_ID":48786,"compounds":"D-erythrose 4-phosphate => D-erythrulose 4-phosphate"}
{"X":40598,"RHEA_ID":38893,"compounds":"hexadecanoate + sphing-4-enine => H2O + N-hexadecanoylsphing-4-enine"}
{"X":40599,"RHEA_ID":38894,"compounds":"H2O + N-hexadecanoylsphing-4-enine <=> hexadecanoate + sphing-4-enine"}
{"X":40600,"RHEA_ID":38895,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)"}
{"X":40601,"RHEA_ID":48794,"compounds":"alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+) => GDP-beta-L-fucose + Lc4Cer"}
{"X":40602,"RHEA_ID":38897,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in)"}
{"X":40603,"RHEA_ID":38898,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)"}
{"X":40604,"RHEA_ID":38899,"compounds":"a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(out) = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(in)"}
{"X":40605,"RHEA_ID":48798,"compounds":"19-hydroxyprostaglandin H1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + prostaglandin H1 + reduced [NADPH--hemoprotein reductase]"}
{"X":40606,"RHEA_ID":38901,"compounds":"a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(in) => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(out)"}
{"X":40607,"RHEA_ID":38902,"compounds":"a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(out) <=> a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(in)"}
{"X":40608,"RHEA_ID":38903,"compounds":"ATP + H2O + sphingomyelin(in) = ADP + H(+) + phosphate + sphingomyelin(out)"}
{"X":40609,"RHEA_ID":48802,"compounds":"a neolactoside IV(2)-alpha-Fuc-nLc4Cer + GDP + H(+) => a neolactoside nLc4Cer + GDP-beta-L-fucose"}
{"X":40610,"RHEA_ID":38905,"compounds":"ADP + H(+) + phosphate + sphingomyelin(out) => ATP + H2O + sphingomyelin(in)"}
{"X":40611,"RHEA_ID":38906,"compounds":"ATP + H2O + sphingomyelin(in) <=> ADP + H(+) + phosphate + sphingomyelin(out)"}
{"X":40612,"RHEA_ID":38907,"DIRECTION":"UN","MASTER_ID":38907,"ec":"2.1.1.291","compounds":"(R)-reticuline + S-adenosyl-L-methionine = (R)-laudanine + H(+) + S-adenosyl-L-homocysteine"}
{"X":40613,"RHEA_ID":48806,"compounds":"(5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O => (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2"}
{"X":40614,"RHEA_ID":38909,"compounds":"(R)-laudanine + H(+) + S-adenosyl-L-homocysteine => (R)-reticuline + S-adenosyl-L-methionine"}
{"X":40615,"RHEA_ID":48808,"compounds":"(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O"}
{"X":40616,"RHEA_ID":38911,"DIRECTION":"UN","MASTER_ID":38911,"ec":"3.2.1.188","compounds":"avenacoside B + H2O = 26-desgluco-avenacoside B + D-glucose"}
{"X":40617,"RHEA_ID":48810,"compounds":"(5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O => (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2"}
{"X":40618,"RHEA_ID":38913,"compounds":"26-desgluco-avenacoside B + D-glucose => avenacoside B + H2O"}
{"X":40619,"RHEA_ID":38915,"compounds":"a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + choline + H(+)"}
{"X":40620,"RHEA_ID":48814,"compounds":"(5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O => (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2"}
{"X":40621,"RHEA_ID":38917,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + choline + H(+) => a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O"}
{"X":40622,"RHEA_ID":38918,"compounds":"a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + choline + H(+)"}
{"X":40623,"RHEA_ID":38919,"compounds":"H2O + sphing-4-enine-phosphocholine = choline + H(+) + sphing-4-enine 1-phosphate"}
{"X":40624,"RHEA_ID":48818,"compounds":"17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2"}
{"X":40625,"RHEA_ID":48819,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 <=> 17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O"}
{"X":40626,"RHEA_ID":48820,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O"}
{"X":40627,"RHEA_ID":38923,"compounds":"a ubiquinone + H(+) + Na(+)(in) + NADH = a ubiquinol + Na(+)(out) + NAD(+)"}
{"X":40628,"RHEA_ID":38924,"DIRECTION":"LR","MASTER_ID":38923,"metacyc":"TRANS-RXN-214","compounds":"a ubiquinone + H(+) + Na(+)(in) + NADH => a ubiquinol + Na(+)(out) + NAD(+)"}
{"X":40629,"RHEA_ID":48823,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 <=> 13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O"}
{"X":40630,"RHEA_ID":38926,"compounds":"a ubiquinone + H(+) + Na(+)(in) + NADH <=> a ubiquinol + Na(+)(out) + NAD(+)"}
{"X":40631,"RHEA_ID":38927,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ethanolamine + H(+)"}
{"X":40632,"RHEA_ID":38928,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ethanolamine + H(+)"}
{"X":40633,"RHEA_ID":38929,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ethanolamine + H(+) => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O"}
{"X":40634,"RHEA_ID":38930,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ethanolamine + H(+)"}
{"X":40635,"RHEA_ID":38931,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + L-serine"}
{"X":40636,"RHEA_ID":38932,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + L-serine"}
{"X":40637,"RHEA_ID":58861,"DIRECTION":"LR","MASTER_ID":58860,"metacyc":"RXN-11925","compounds":"4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":40638,"RHEA_ID":38934,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + L-serine"}
{"X":40639,"RHEA_ID":38935,"DIRECTION":"UN","MASTER_ID":38935,"ec":"1.3.8.11","compounds":"cyclohexane-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = cyclohex-1-ene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":40640,"RHEA_ID":38936,"compounds":"cyclohexane-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => cyclohex-1-ene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":40641,"RHEA_ID":48835,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate"}
{"X":40642,"RHEA_ID":48836,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O"}
{"X":40643,"RHEA_ID":38939,"DIRECTION":"UN","MASTER_ID":38939,"ec":"3.2.1.190","compounds":"dioscin + 2 H2O = diosgenin 3-beta-D-glucoside + 2 L-rhamnopyranose"}
{"X":40644,"RHEA_ID":38940,"DIRECTION":"LR","MASTER_ID":38939,"metacyc":"RXN-14574","compounds":"dioscin + 2 H2O => diosgenin 3-beta-D-glucoside + 2 L-rhamnopyranose"}
{"X":40645,"RHEA_ID":48839,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 <=> (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O"}
{"X":40646,"RHEA_ID":48840,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O"}
{"X":40647,"RHEA_ID":38943,"compounds":"a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ATP + H2O = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ADP + H(+) + phosphate"}
{"X":40648,"RHEA_ID":38944,"compounds":"a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ATP + H2O => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ADP + H(+) + phosphate"}
{"X":40649,"RHEA_ID":48843,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 <=> (15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O"}
{"X":40650,"RHEA_ID":38946,"compounds":"a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ATP + H2O <=> a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ADP + H(+) + phosphate"}
{"X":40651,"RHEA_ID":38947,"compounds":"dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 12-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":40652,"RHEA_ID":38948,"compounds":"dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 12-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":40653,"RHEA_ID":48847,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate"}
{"X":40654,"RHEA_ID":38950,"compounds":"dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 12-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":40655,"RHEA_ID":38951,"compounds":"ATP + H2O + sphing-4-enine 1-phosphate(in) = ADP + H(+) + phosphate + sphing-4-enine 1-phosphate(out)"}
{"X":40656,"RHEA_ID":38952,"compounds":"ATP + H2O + sphing-4-enine 1-phosphate(in) => ADP + H(+) + phosphate + sphing-4-enine 1-phosphate(out)"}
{"X":40657,"RHEA_ID":38953,"compounds":"ADP + H(+) + phosphate + sphing-4-enine 1-phosphate(out) => ATP + H2O + sphing-4-enine 1-phosphate(in)"}
{"X":40658,"RHEA_ID":38954,"compounds":"ATP + H2O + sphing-4-enine 1-phosphate(in) <=> ADP + H(+) + phosphate + sphing-4-enine 1-phosphate(out)"}
{"X":40659,"RHEA_ID":38955,"compounds":"N-acylsphing-4-enine 1-phosphate(in) = N-acylsphing-4-enine 1-phosphate(out)"}
{"X":40660,"RHEA_ID":38956,"compounds":"N-acylsphing-4-enine 1-phosphate(in) => N-acylsphing-4-enine 1-phosphate(out)"}
{"X":40661,"RHEA_ID":48855,"compounds":"(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2 <=> 13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O"}
{"X":40662,"RHEA_ID":38958,"compounds":"N-acylsphing-4-enine 1-phosphate(in) <=> N-acylsphing-4-enine 1-phosphate(out)"}
{"X":40663,"RHEA_ID":38959,"DIRECTION":"UN","MASTER_ID":38959,"ec":"1.3.3.6","compounds":"a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2"}
{"X":40664,"RHEA_ID":38960,"DIRECTION":"LR","MASTER_ID":38959,"metacyc":"ACYL-COA-OXIDASE-RXN","compounds":"a 2,3-saturated acyl-CoA + O2 => a (2E)-enoyl-CoA + H2O2"}
{"X":40665,"RHEA_ID":48859,"compounds":"(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 <=> (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + A + H2O"}
{"X":40666,"RHEA_ID":38961,"compounds":"a (2E)-enoyl-CoA + H2O2 => a 2,3-saturated acyl-CoA + O2"}
{"X":40667,"RHEA_ID":38963,"compounds":"ATP + H2O + leukotriene C4(in) = ADP + H(+) + leukotriene C4(out) + phosphate"}
{"X":40668,"RHEA_ID":48863,"compounds":"18-HEPE + O2 <=> (5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate"}
{"X":40669,"RHEA_ID":38965,"compounds":"ADP + H(+) + leukotriene C4(out) + phosphate => ATP + H2O + leukotriene C4(in)"}
{"X":40670,"RHEA_ID":38966,"compounds":"ATP + H2O + leukotriene C4(in) <=> ADP + H(+) + leukotriene C4(out) + phosphate"}
{"X":40671,"RHEA_ID":38967,"compounds":"an N-acylsphing-4-enine(in) + ATP + H2O = ADP + an N-acylsphing-4-enine(out) + H(+) + phosphate"}
{"X":40672,"RHEA_ID":38968,"compounds":"an N-acylsphing-4-enine(in) + ATP + H2O => ADP + an N-acylsphing-4-enine(out) + H(+) + phosphate"}
{"X":40673,"RHEA_ID":38969,"compounds":"ADP + an N-acylsphing-4-enine(out) + H(+) + phosphate => an N-acylsphing-4-enine(in) + ATP + H2O"}
{"X":40674,"RHEA_ID":38970,"compounds":"an N-acylsphing-4-enine(in) + ATP + H2O <=> ADP + an N-acylsphing-4-enine(out) + H(+) + phosphate"}
{"X":40675,"RHEA_ID":38971,"compounds":"O2 + octadecanoyl-CoA = (2E)-octadecenoyl-CoA + H2O2"}
{"X":40676,"RHEA_ID":38972,"compounds":"O2 + octadecanoyl-CoA => (2E)-octadecenoyl-CoA + H2O2"}
{"X":40677,"RHEA_ID":38973,"compounds":"(2E)-octadecenoyl-CoA + H2O2 => O2 + octadecanoyl-CoA"}
{"X":40678,"RHEA_ID":38974,"compounds":"O2 + octadecanoyl-CoA <=> (2E)-octadecenoyl-CoA + H2O2"}
{"X":40679,"RHEA_ID":38975,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)"}
{"X":40680,"RHEA_ID":58913,"DIRECTION":"LR","MASTER_ID":58912,"ecocyc":"ABC-9-RXN","metacyc":"ABC-9-RXN","compounds":"ATP + H2O + iron(III) dicitrate(out) => ADP + H(+) + iron(III) dicitrate(in) + phosphate"}
{"X":40681,"RHEA_ID":38977,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+) => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":40682,"RHEA_ID":38978,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)"}
{"X":40683,"RHEA_ID":38979,"compounds":"1-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphate + choline + H(+)"}
{"X":40684,"RHEA_ID":38981,"compounds":"1-octadecanoyl-sn-glycero-3-phosphate + choline + H(+) => 1-octadecanoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":40685,"RHEA_ID":38982,"compounds":"1-octadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphate + choline + H(+)"}
{"X":40686,"RHEA_ID":38983,"compounds":"1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycerol 3-phosphate + choline + H(+)"}
{"X":40687,"RHEA_ID":38985,"compounds":"1-tetradecanoyl-sn-glycerol 3-phosphate + choline + H(+) => 1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":40688,"RHEA_ID":38986,"compounds":"1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-tetradecanoyl-sn-glycerol 3-phosphate + choline + H(+)"}
{"X":40689,"RHEA_ID":38987,"compounds":"nonanoyl-CoA + O2 = (2E)-nonenoyl-CoA + H2O2"}
{"X":40690,"RHEA_ID":58925,"DIRECTION":"LR","MASTER_ID":58924,"metacyc":"RXN-13700","compounds":"(3R,4R)-3-(6-hydroxy-1,3-benzodioxol-5-yl)-3,4-dihydro-2H-chromene-4,7-diol => (-)-maackiain + H2O"}
{"X":40691,"RHEA_ID":38989,"compounds":"(2E)-nonenoyl-CoA + H2O2 => nonanoyl-CoA + O2"}
{"X":40692,"RHEA_ID":38990,"compounds":"nonanoyl-CoA + O2 <=> (2E)-nonenoyl-CoA + H2O2"}
{"X":40693,"RHEA_ID":38991,"compounds":"1-dodecanoyl-sn-glycero-3-phosphocholine + H2O = 1-dodecanoyl-sn-glycerol 3-phosphate + choline + H(+)"}
{"X":40694,"RHEA_ID":48891,"compounds":"(13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione <=> (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O"}
{"X":40695,"RHEA_ID":38993,"compounds":"1-dodecanoyl-sn-glycerol 3-phosphate + choline + H(+) => 1-dodecanoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":40696,"RHEA_ID":38994,"compounds":"1-dodecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-dodecanoyl-sn-glycerol 3-phosphate + choline + H(+)"}
{"X":40697,"RHEA_ID":38995,"DIRECTION":"UN","MASTER_ID":38995,"ec":"3.1.4.4","compounds":"a 1-acyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphate + choline + H(+)"}
{"X":40698,"RHEA_ID":38997,"compounds":"a 1-acyl-sn-glycero-3-phosphate + choline + H(+) => a 1-acyl-sn-glycero-3-phosphocholine + H2O"}
{"X":40699,"RHEA_ID":38998,"compounds":"a 1-acyl-sn-glycero-3-phosphocholine + H2O <=> a 1-acyl-sn-glycero-3-phosphate + choline + H(+)"}
{"X":40700,"RHEA_ID":38999,"compounds":"a 1-acyl-sn-glycero-3-phospho-L-serine + H2O = a 1-acyl-sn-glycero-3-phosphate + H(+) + L-serine"}
{"X":40701,"RHEA_ID":39000,"compounds":"a 1-acyl-sn-glycero-3-phospho-L-serine + H2O => a 1-acyl-sn-glycero-3-phosphate + H(+) + L-serine"}
{"X":40702,"RHEA_ID":39001,"compounds":"a 1-acyl-sn-glycero-3-phosphate + H(+) + L-serine => a 1-acyl-sn-glycero-3-phospho-L-serine + H2O"}
{"X":40703,"RHEA_ID":39002,"compounds":"a 1-acyl-sn-glycero-3-phospho-L-serine + H2O <=> a 1-acyl-sn-glycero-3-phosphate + H(+) + L-serine"}
{"X":40704,"RHEA_ID":39003,"compounds":"a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-acyl-sn-glycero-3-phosphate + ethanolamine + H(+)"}
{"X":40705,"RHEA_ID":48903,"compounds":"chlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 3,8-divinyl chlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":40706,"RHEA_ID":39005,"compounds":"a 1-acyl-sn-glycero-3-phosphate + ethanolamine + H(+) => a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O"}
{"X":40707,"RHEA_ID":39006,"compounds":"a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> a 1-acyl-sn-glycero-3-phosphate + ethanolamine + H(+)"}
{"X":40708,"RHEA_ID":39007,"compounds":"a cholesterol ester(in) = a cholesterol ester(out)"}
{"X":40709,"RHEA_ID":39008,"compounds":"a cholesterol ester(in) => a cholesterol ester(out)"}
{"X":40710,"RHEA_ID":39009,"DIRECTION":"RL","MASTER_ID":39007,"reactome":"R-HSA-8876731.1","compounds":"a cholesterol ester(out) => a cholesterol ester(in)"}
{"X":40711,"RHEA_ID":39010,"compounds":"a cholesterol ester(in) <=> a cholesterol ester(out)"}
{"X":40712,"RHEA_ID":39011,"compounds":"a triacyl-sn-glycerol(in) = a triacyl-sn-glycerol(out)"}
{"X":40713,"RHEA_ID":58949,"compounds":"4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine => 4-O-([3-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP"}
{"X":40714,"RHEA_ID":39013,"compounds":"a triacyl-sn-glycerol(out) => a triacyl-sn-glycerol(in)"}
{"X":40715,"RHEA_ID":39014,"compounds":"a triacyl-sn-glycerol(in) <=> a triacyl-sn-glycerol(out)"}
{"X":40716,"RHEA_ID":39015,"compounds":"22-oxodocosanoate + H2O + NAD(+) = docosanedioate + 2 H(+) + NADH"}
{"X":40717,"RHEA_ID":48915,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GD1a <=> CMP + ganglioside GT1a + H(+)"}
{"X":40718,"RHEA_ID":39017,"compounds":"docosanedioate + 2 H(+) + NADH => 22-oxodocosanoate + H2O + NAD(+)"}
{"X":40719,"RHEA_ID":39018,"compounds":"22-oxodocosanoate + H2O + NAD(+) <=> docosanedioate + 2 H(+) + NADH"}
{"X":40720,"RHEA_ID":39019,"DIRECTION":"UN","MASTER_ID":39019,"ec":"3.1.3.95","compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate"}
{"X":40721,"RHEA_ID":48919,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GM1b <=> CMP + ganglioside GD1c + H(+)"}
{"X":40722,"RHEA_ID":39021,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O"}
{"X":40723,"RHEA_ID":39022,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate"}
{"X":40724,"RHEA_ID":39023,"compounds":"an omega-methyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":40725,"RHEA_ID":58961,"compounds":"benzaldehyde + H2O + O2 => benzoate + H(+) + H2O2"}
{"X":40726,"RHEA_ID":39025,"compounds":"an omega-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an omega-methyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":40727,"RHEA_ID":39026,"compounds":"an omega-methyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an omega-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":40728,"RHEA_ID":39027,"DIRECTION":"UN","MASTER_ID":39027,"ec":"2.4.1.315","compounds":"a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + UDP-alpha-D-glucose = a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP"}
{"X":40729,"RHEA_ID":39028,"compounds":"a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + UDP-alpha-D-glucose => a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP"}
{"X":40730,"RHEA_ID":39029,"compounds":"a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + UDP-alpha-D-glucose"}
{"X":40731,"RHEA_ID":48929,"compounds":"CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-D-galactosylceramide => CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide"}
{"X":40732,"RHEA_ID":39031,"DIRECTION":"UN","MASTER_ID":39031,"ec":"2.4.1.315","compounds":"a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose = a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP"}
{"X":40733,"RHEA_ID":48931,"compounds":"CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-D-galactosylceramide <=> CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide"}
{"X":40734,"RHEA_ID":39033,"compounds":"a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose"}
{"X":40735,"RHEA_ID":48933,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GT1b => CMP + ganglioside GQ1b + H(+)"}
{"X":40736,"RHEA_ID":39035,"compounds":"an omega-hydroxy fatty acid + NAD(+) = an omega-oxo fatty acid + H(+) + NADH"}
{"X":40737,"RHEA_ID":48935,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GT1b <=> CMP + ganglioside GQ1b + H(+)"}
{"X":40738,"RHEA_ID":39037,"compounds":"an omega-oxo fatty acid + H(+) + NADH => an omega-hydroxy fatty acid + NAD(+)"}
{"X":40739,"RHEA_ID":39038,"compounds":"an omega-hydroxy fatty acid + NAD(+) <=> an omega-oxo fatty acid + H(+) + NADH"}
{"X":40740,"RHEA_ID":39039,"compounds":"an omega-oxo fatty acid + H2O + NAD(+) = a dicarboxylate + 2 H(+) + NADH"}
{"X":40741,"RHEA_ID":39040,"compounds":"an omega-oxo fatty acid + H2O + NAD(+) => a dicarboxylate + 2 H(+) + NADH"}
{"X":40742,"RHEA_ID":39041,"compounds":"a dicarboxylate + 2 H(+) + NADH => an omega-oxo fatty acid + H2O + NAD(+)"}
{"X":40743,"RHEA_ID":39042,"compounds":"an omega-oxo fatty acid + H2O + NAD(+) <=> a dicarboxylate + 2 H(+) + NADH"}
{"X":40744,"RHEA_ID":39043,"compounds":"22-oxodocosanoate + O2 + reduced [NADPH--hemoprotein reductase] = docosanedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":40745,"RHEA_ID":39044,"compounds":"22-oxodocosanoate + O2 + reduced [NADPH--hemoprotein reductase] => docosanedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":40746,"RHEA_ID":39045,"compounds":"docosanedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 22-oxodocosanoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":40747,"RHEA_ID":39046,"compounds":"22-oxodocosanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> docosanedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":40748,"RHEA_ID":39047,"compounds":"26-oxohexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + hexacosanedioate + oxidized [NADPH--hemoprotein reductase]"}
{"X":40749,"RHEA_ID":48946,"DIRECTION":"RL","MASTER_ID":48944,"metacyc":"RXN-17425","compounds":"3-acetyl-3-devinylchlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin] => ADP + bacteriochlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate"}
{"X":40750,"RHEA_ID":39049,"compounds":"2 H(+) + H2O + hexacosanedioate + oxidized [NADPH--hemoprotein reductase] => 26-oxohexacosanoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":40751,"RHEA_ID":39050,"compounds":"26-oxohexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + hexacosanedioate + oxidized [NADPH--hemoprotein reductase]"}
{"X":40752,"RHEA_ID":39051,"compounds":"ATP + cholesterol(in) + H2O = ADP + cholesterol(out) + H(+) + phosphate"}
{"X":40753,"RHEA_ID":48950,"DIRECTION":"RL","MASTER_ID":48948,"metacyc":"RXN-8786","compounds":"3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin] => 3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate"}
{"X":40754,"RHEA_ID":39053,"compounds":"ADP + cholesterol(out) + H(+) + phosphate => ATP + cholesterol(in) + H2O"}
{"X":40755,"RHEA_ID":52326,"compounds":"5 H(+) + 4 H2O + 2 L-citrulline + 2 nitric oxide + 3 oxidized [flavodoxin] => 2 L-arginine + 4 O2 + 3 reduced [flavodoxin]"}
{"X":40756,"RHEA_ID":39055,"compounds":"22-hydroxydocosanoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-oxodocosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":40757,"RHEA_ID":48954,"compounds":"14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + H(+) + NADH => 14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+)"}
{"X":40758,"RHEA_ID":39057,"compounds":"22-oxodocosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 22-hydroxydocosanoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":40759,"RHEA_ID":39058,"compounds":"22-hydroxydocosanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 22-oxodocosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":40760,"RHEA_ID":39059,"compounds":"26-hydroxyhexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] = 26-oxohexacosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":40761,"RHEA_ID":39060,"compounds":"26-hydroxyhexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] => 26-oxohexacosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":40762,"RHEA_ID":39061,"compounds":"26-oxohexacosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 26-hydroxyhexacosanoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":40763,"RHEA_ID":39062,"compounds":"26-hydroxyhexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 26-oxohexacosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":40764,"RHEA_ID":39063,"DIRECTION":"UN","MASTER_ID":39063,"ec":"1.1.1.371","compounds":"NADP(+) + scyllo-inositol = H(+) + NADPH + scyllo-inosose"}
{"X":40765,"RHEA_ID":48962,"compounds":"[thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O => [thyroglobulin]-3-iodo-L-tyrosine + H(+) + H2O2 + iodide"}
{"X":40766,"RHEA_ID":39065,"compounds":"H(+) + NADPH + scyllo-inosose => NADP(+) + scyllo-inositol"}
{"X":40767,"RHEA_ID":48964,"DIRECTION":"UN","MASTER_ID":48964,"ec":"1.11.1.8","compounds":"2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-dehydroalanine + [thyroglobulin]-L-thyroxine + 2 H2O"}
{"X":40768,"RHEA_ID":39067,"compounds":"3-oxooctanedioyl-CoA + CoA = acetyl-CoA + hexanedioyl-CoA"}
{"X":40769,"RHEA_ID":39068,"compounds":"3-oxooctanedioyl-CoA + CoA => acetyl-CoA + hexanedioyl-CoA"}
{"X":40770,"RHEA_ID":39070,"compounds":"3-oxooctanedioyl-CoA + CoA <=> acetyl-CoA + hexanedioyl-CoA"}
{"X":40771,"RHEA_ID":39071,"compounds":"dodecanedioyl-CoA + O2 = (2E)-dodecenedioyl-CoA + H2O2"}
{"X":40772,"RHEA_ID":39072,"compounds":"dodecanedioyl-CoA + O2 => (2E)-dodecenedioyl-CoA + H2O2"}
{"X":40773,"RHEA_ID":39074,"compounds":"dodecanedioyl-CoA + O2 <=> (2E)-dodecenedioyl-CoA + H2O2"}
{"X":40774,"RHEA_ID":39075,"compounds":"(2E)-dodecenedioyl-CoA + H2O = (3S)-hydroxydodecanedioyl-CoA"}
{"X":40775,"RHEA_ID":39076,"compounds":"(2E)-dodecenedioyl-CoA + H2O => (3S)-hydroxydodecanedioyl-CoA"}
{"X":40776,"RHEA_ID":48975,"compounds":"ATP + H2O + phosphite(out) <=> ADP + H(+) + phosphate + phosphite(in)"}
{"X":40777,"RHEA_ID":39078,"compounds":"(2E)-dodecenedioyl-CoA + H2O <=> (3S)-hydroxydodecanedioyl-CoA"}
{"X":40778,"RHEA_ID":39079,"compounds":"(3S)-hydroxydodecanedioyl-CoA + NAD(+) = 3-oxododecanedioyl-CoA + H(+) + NADH"}
{"X":40779,"RHEA_ID":39080,"compounds":"(3S)-hydroxydodecanedioyl-CoA + NAD(+) => 3-oxododecanedioyl-CoA + H(+) + NADH"}
{"X":40780,"RHEA_ID":59018,"compounds":"CO2 + cycloeucalenone + NADH => 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + NAD(+)"}
{"X":40781,"RHEA_ID":39082,"compounds":"(3S)-hydroxydodecanedioyl-CoA + NAD(+) <=> 3-oxododecanedioyl-CoA + H(+) + NADH"}
{"X":40782,"RHEA_ID":39083,"compounds":"3-oxododecanedioyl-CoA + CoA = acetyl-CoA + decanedioyl-CoA"}
{"X":40783,"RHEA_ID":39084,"compounds":"3-oxododecanedioyl-CoA + CoA => acetyl-CoA + decanedioyl-CoA"}
{"X":40784,"RHEA_ID":48983,"compounds":"3,4-dichlorocatechol + O2 <=> (2Z,4Z)-2,3-dichloromuconate + 2 H(+)"}
{"X":40785,"RHEA_ID":39086,"compounds":"3-oxododecanedioyl-CoA + CoA <=> acetyl-CoA + decanedioyl-CoA"}
{"X":40786,"RHEA_ID":39087,"compounds":"decanedioyl-CoA + O2 = (2E)-decenedioyl-CoA + H2O2"}
{"X":40787,"RHEA_ID":39088,"compounds":"decanedioyl-CoA + O2 => (2E)-decenedioyl-CoA + H2O2"}
{"X":40788,"RHEA_ID":39089,"compounds":"(2E)-decenedioyl-CoA + H2O2 => decanedioyl-CoA + O2"}
{"X":40789,"RHEA_ID":39090,"compounds":"decanedioyl-CoA + O2 <=> (2E)-decenedioyl-CoA + H2O2"}
{"X":40790,"RHEA_ID":39091,"compounds":"(2E)-decenedioyl-CoA + H2O = (3S)-hydroxydecanedioyl-CoA"}
{"X":40791,"RHEA_ID":39092,"compounds":"(2E)-decenedioyl-CoA + H2O => (3S)-hydroxydecanedioyl-CoA"}
{"X":40792,"RHEA_ID":39093,"compounds":"(3S)-hydroxydecanedioyl-CoA => (2E)-decenedioyl-CoA + H2O"}
{"X":40793,"RHEA_ID":39094,"compounds":"(2E)-decenedioyl-CoA + H2O <=> (3S)-hydroxydecanedioyl-CoA"}
{"X":40794,"RHEA_ID":39095,"compounds":"(3S)-hydroxydecanedioyl-CoA + NAD(+) = 3-oxodecanedioyl-CoA + H(+) + NADH"}
{"X":40795,"RHEA_ID":39096,"compounds":"(3S)-hydroxydecanedioyl-CoA + NAD(+) => 3-oxodecanedioyl-CoA + H(+) + NADH"}
{"X":40796,"RHEA_ID":39097,"compounds":"3-oxodecanedioyl-CoA + H(+) + NADH => (3S)-hydroxydecanedioyl-CoA + NAD(+)"}
{"X":40797,"RHEA_ID":52378,"compounds":"(+)-sesamin dicatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) => (+)-sesamin monocatechol + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n"}
{"X":40798,"RHEA_ID":39099,"compounds":"3-oxodecanedioyl-CoA + CoA = acetyl-CoA + octanedioyl-CoA"}
{"X":40799,"RHEA_ID":39100,"compounds":"3-oxodecanedioyl-CoA + CoA => acetyl-CoA + octanedioyl-CoA"}
{"X":40800,"RHEA_ID":59038,"compounds":"4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}
{"X":40801,"RHEA_ID":39102,"compounds":"3-oxodecanedioyl-CoA + CoA <=> acetyl-CoA + octanedioyl-CoA"}
{"X":40802,"RHEA_ID":39103,"compounds":"(24R)-ethylcholest-5-en-3beta-ol(in) + ATP + H2O = (24R)-ethylcholest-5-en-3beta-ol(out) + ADP + H(+) + phosphate"}
{"X":40803,"RHEA_ID":39104,"compounds":"(24R)-ethylcholest-5-en-3beta-ol(in) + ATP + H2O => (24R)-ethylcholest-5-en-3beta-ol(out) + ADP + H(+) + phosphate"}
{"X":40804,"RHEA_ID":39105,"compounds":"(24R)-ethylcholest-5-en-3beta-ol(out) + ADP + H(+) + phosphate => (24R)-ethylcholest-5-en-3beta-ol(in) + ATP + H2O"}
{"X":40805,"RHEA_ID":39106,"compounds":"(24R)-ethylcholest-5-en-3beta-ol(in) + ATP + H2O <=> (24R)-ethylcholest-5-en-3beta-ol(out) + ADP + H(+) + phosphate"}
{"X":40806,"RHEA_ID":39107,"compounds":"(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate = (5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O"}
{"X":40807,"RHEA_ID":39108,"compounds":"(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate => (5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O"}
{"X":40808,"RHEA_ID":59046,"compounds":"(20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + H(+) + UDP => dammarenediol-II + UDP-alpha-D-glucose"}
{"X":40809,"RHEA_ID":39110,"compounds":"(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate <=> (5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O"}
{"X":40810,"RHEA_ID":39111,"DIRECTION":"UN","MASTER_ID":39111,"ec":"1.3.1.105","compounds":"4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NADP(+) = 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADPH"}
{"X":40811,"RHEA_ID":39112,"compounds":"4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NADP(+) => 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADPH"}
{"X":40812,"RHEA_ID":39113,"DIRECTION":"RL","MASTER_ID":39111,"metacyc":"RXN-9563","compounds":"4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADPH => 4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NADP(+)"}
{"X":40813,"RHEA_ID":52394,"compounds":"4-phospho-D-erythronate + ADP + H(+) => ATP + D-erythronate"}
{"X":40814,"RHEA_ID":39115,"DIRECTION":"UN","MASTER_ID":39115,"ec":"1.3.1.105","compounds":"4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NAD(+) = 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADH"}
{"X":40815,"RHEA_ID":39116,"compounds":"4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NAD(+) => 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADH"}
{"X":40816,"RHEA_ID":39117,"DIRECTION":"RL","MASTER_ID":39115,"metacyc":"RXN-9563","compounds":"4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADH => 4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NAD(+)"}
{"X":40817,"RHEA_ID":49017,"DIRECTION":"LR","MASTER_ID":49016,"metacyc":"RXN-17356","compounds":"aurachin C epoxide => 2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one"}
{"X":40818,"RHEA_ID":39120,"DIRECTION":"LR","MASTER_ID":39119,"reactome":"R-HSA-2066787.1","compounds":"(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + O2 => (2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O2"}
{"X":40819,"RHEA_ID":39121,"compounds":"(2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O2 => (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + O2"}
{"X":40820,"RHEA_ID":39122,"compounds":"(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + O2 <=> (2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O2"}
{"X":40821,"RHEA_ID":49021,"DIRECTION":"LR","MASTER_ID":49020,"metacyc":"RXN-17334","compounds":"2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one => 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide"}
{"X":40822,"RHEA_ID":39124,"compounds":"(2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O => (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA"}
{"X":40823,"RHEA_ID":39125,"compounds":"(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA => (2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O"}
{"X":40824,"RHEA_ID":52406,"compounds":"CO2 + dihydroxyacetone phosphate => 3-dehydro-4-O-phospho-L-erythronate + H(+)"}
{"X":40825,"RHEA_ID":49025,"DIRECTION":"LR","MASTER_ID":49024,"metacyc":"RXN-10922","compounds":"L-tryptophan + O2 => 2-iminio-3-(indol-3-yl)propanoate + H2O2"}
{"X":40826,"RHEA_ID":39128,"compounds":"(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + NAD(+) => 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADH"}
{"X":40827,"RHEA_ID":39129,"compounds":"3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADH => (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + NAD(+)"}
{"X":40828,"RHEA_ID":39130,"compounds":"(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + NAD(+) <=> 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADH"}
{"X":40829,"RHEA_ID":49029,"DIRECTION":"LR","MASTER_ID":49028,"metacyc":"RXN-17347","compounds":"(-)-bursehernin + O2 + reduced [NADPH--hemoprotein reductase] => (-)-5'-demethylyatein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":40830,"RHEA_ID":39132,"DIRECTION":"LR","MASTER_ID":39131,"reactome":"R-HSA-2066788.2","compounds":"3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + acetyl-CoA"}
{"X":40831,"RHEA_ID":39133,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + acetyl-CoA => 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CoA"}
{"X":40832,"RHEA_ID":39134,"compounds":"3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CoA <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + acetyl-CoA"}
{"X":40833,"RHEA_ID":52415,"compounds":"4-phospho-D-erythronate + NAD(+) <=> 3-dehydro-4-O-phospho-D-erythronate + H(+) + NADH"}
{"X":40834,"RHEA_ID":39136,"compounds":"(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + O2 => (2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O2"}
{"X":40835,"RHEA_ID":39137,"compounds":"(2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O2 => (6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + O2"}
{"X":40836,"RHEA_ID":39138,"compounds":"(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + O2 <=> (2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O2"}
{"X":40837,"RHEA_ID":49037,"DIRECTION":"LR","MASTER_ID":49036,"metacyc":"RXN-16361","compounds":"(-)-pluviatolide + S-adenosyl-L-methionine => (-)-bursehernin + H(+) + S-adenosyl-L-homocysteine"}
{"X":40838,"RHEA_ID":39140,"compounds":"(2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O => (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA"}
{"X":40839,"RHEA_ID":39141,"compounds":"(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA => (2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O"}
{"X":40840,"RHEA_ID":39142,"compounds":"(2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O <=> (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA"}
{"X":40841,"RHEA_ID":39143,"compounds":"(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + NAD(+) = 3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADH"}
{"X":40842,"RHEA_ID":39144,"compounds":"(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + NAD(+) => 3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADH"}
{"X":40843,"RHEA_ID":39145,"compounds":"3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADH => (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + NAD(+)"}
{"X":40844,"RHEA_ID":39146,"compounds":"(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + NAD(+) <=> 3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADH"}
{"X":40845,"RHEA_ID":39147,"compounds":"3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + CoA = (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + acetyl-CoA"}
{"X":40846,"RHEA_ID":39148,"compounds":"3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + CoA => (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + acetyl-CoA"}
{"X":40847,"RHEA_ID":39149,"compounds":"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + acetyl-CoA => 3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + CoA"}
{"X":40848,"RHEA_ID":39150,"compounds":"3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + CoA <=> (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + acetyl-CoA"}
{"X":40849,"RHEA_ID":49049,"compounds":"25-hydroxyvitamin D2 + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 1alpha,25-dihydroxyvitamin D2 + H2O + 2 oxidized [adrenodoxin]"}
{"X":40850,"RHEA_ID":39152,"compounds":"3-oxooctadecanoyl-CoA + H(+) + NADPH => (3R)-hydroxyoctadecanoyl-CoA + NADP(+)"}
{"X":40851,"RHEA_ID":39153,"compounds":"(3R)-hydroxyoctadecanoyl-CoA + NADP(+) => 3-oxooctadecanoyl-CoA + H(+) + NADPH"}
{"X":40852,"RHEA_ID":39154,"compounds":"3-oxooctadecanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxyoctadecanoyl-CoA + NADP(+)"}
{"X":40853,"RHEA_ID":49053,"DIRECTION":"LR","MASTER_ID":49052,"metacyc":"RXN-15799","compounds":"asperlicin C + H(+) + NADH + O2 => asperlicin E + H2O + NAD(+)"}
{"X":40854,"RHEA_ID":39156,"compounds":"(3R)-hydroxyoctadecanoyl-CoA => (2E)-octadecenoyl-CoA + H2O"}
{"X":40855,"RHEA_ID":39157,"compounds":"(2E)-octadecenoyl-CoA + H2O => (3R)-hydroxyoctadecanoyl-CoA"}
{"X":40856,"RHEA_ID":39158,"compounds":"(3R)-hydroxyoctadecanoyl-CoA <=> (2E)-octadecenoyl-CoA + H2O"}
{"X":40857,"RHEA_ID":39159,"compounds":"(3R)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2O"}
{"X":40858,"RHEA_ID":39160,"compounds":"(3R)-hydroxyhexadecanoyl-CoA => (2E)-hexadecenoyl-CoA + H2O"}
{"X":40859,"RHEA_ID":39161,"compounds":"(2E)-hexadecenoyl-CoA + H2O => (3R)-hydroxyhexadecanoyl-CoA"}
{"X":40860,"RHEA_ID":39162,"compounds":"(3R)-hydroxyhexadecanoyl-CoA <=> (2E)-hexadecenoyl-CoA + H2O"}
{"X":40861,"RHEA_ID":39163,"compounds":"3-oxohexadecanoyl-CoA + H(+) + NADPH = (3R)-hydroxyhexadecanoyl-CoA + NADP(+)"}
{"X":40862,"RHEA_ID":39164,"compounds":"3-oxohexadecanoyl-CoA + H(+) + NADPH => (3R)-hydroxyhexadecanoyl-CoA + NADP(+)"}
{"X":40863,"RHEA_ID":39165,"compounds":"(3R)-hydroxyhexadecanoyl-CoA + NADP(+) => 3-oxohexadecanoyl-CoA + H(+) + NADPH"}
{"X":40864,"RHEA_ID":39166,"compounds":"3-oxohexadecanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxyhexadecanoyl-CoA + NADP(+)"}
{"X":40865,"RHEA_ID":39167,"compounds":"H(+) + malonyl-CoA + tetradecanoyl-CoA = 3-oxohexadecanoyl-CoA + CO2 + CoA"}
{"X":40866,"RHEA_ID":39168,"compounds":"H(+) + malonyl-CoA + tetradecanoyl-CoA => 3-oxohexadecanoyl-CoA + CO2 + CoA"}
{"X":40867,"RHEA_ID":39169,"compounds":"3-oxohexadecanoyl-CoA + CO2 + CoA => H(+) + malonyl-CoA + tetradecanoyl-CoA"}
{"X":40868,"RHEA_ID":39170,"compounds":"H(+) + malonyl-CoA + tetradecanoyl-CoA <=> 3-oxohexadecanoyl-CoA + CO2 + CoA"}
{"X":40869,"RHEA_ID":39171,"compounds":"3-oxoeicosanoyl-CoA + H(+) + NADPH = (3R)-hydroxyeicosanoyl-CoA + NADP(+)"}
{"X":40870,"RHEA_ID":39172,"compounds":"3-oxoeicosanoyl-CoA + H(+) + NADPH => (3R)-hydroxyeicosanoyl-CoA + NADP(+)"}
{"X":40871,"RHEA_ID":39173,"compounds":"(3R)-hydroxyeicosanoyl-CoA + NADP(+) => 3-oxoeicosanoyl-CoA + H(+) + NADPH"}
{"X":40872,"RHEA_ID":59111,"compounds":"chenodeoxycholate + octyl beta-D-glucose <=> beta-D-glucosyl-(1->3)-O-chenodeoxycholate + octan-1-ol"}
{"X":40873,"RHEA_ID":39175,"compounds":"(3R)-hydroxyeicosanoyl-CoA = (2E)-eicosenoyl-CoA + H2O"}
{"X":40874,"RHEA_ID":39176,"compounds":"(3R)-hydroxyeicosanoyl-CoA => (2E)-eicosenoyl-CoA + H2O"}
{"X":40875,"RHEA_ID":39177,"compounds":"(2E)-eicosenoyl-CoA + H2O => (3R)-hydroxyeicosanoyl-CoA"}
{"X":40876,"RHEA_ID":49076,"compounds":"dibenzothiophene + FMNH2 + O2 = dibenzothiophene 5-oxide + FMN + H(+) + H2O"}
{"X":40877,"RHEA_ID":39179,"compounds":"(2E)-eicosenoyl-CoA + H(+) + NADPH = eicosanoyl-CoA + NADP(+)"}
{"X":40878,"RHEA_ID":39180,"compounds":"(2E)-eicosenoyl-CoA + H(+) + NADPH => eicosanoyl-CoA + NADP(+)"}
{"X":40879,"RHEA_ID":39181,"compounds":"eicosanoyl-CoA + NADP(+) => (2E)-eicosenoyl-CoA + H(+) + NADPH"}
{"X":40880,"RHEA_ID":49080,"compounds":"dibenzothiophene 5-oxide + FMNH2 + O2 = dibenzothiophene 5,5-dioxide + FMN + H(+) + H2O"}
{"X":40881,"RHEA_ID":39183,"compounds":"3-oxodocosanoyl-CoA + H(+) + NADPH = (3R)-hydroxydocosanoyl-CoA + NADP(+)"}
{"X":40882,"RHEA_ID":39184,"compounds":"3-oxodocosanoyl-CoA + H(+) + NADPH => (3R)-hydroxydocosanoyl-CoA + NADP(+)"}
{"X":40883,"RHEA_ID":39185,"compounds":"(3R)-hydroxydocosanoyl-CoA + NADP(+) => 3-oxodocosanoyl-CoA + H(+) + NADPH"}
{"X":40884,"RHEA_ID":59123,"compounds":"2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + H(+) <=> 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + CO2"}
{"X":40885,"RHEA_ID":39187,"compounds":"(3R)-hydroxydocosanoyl-CoA = (2E)-docosenoyl-CoA + H2O"}
{"X":40886,"RHEA_ID":39188,"compounds":"(3R)-hydroxydocosanoyl-CoA => (2E)-docosenoyl-CoA + H2O"}
{"X":40887,"RHEA_ID":39189,"compounds":"(2E)-docosenoyl-CoA + H2O => (3R)-hydroxydocosanoyl-CoA"}
{"X":40888,"RHEA_ID":49088,"DIRECTION":"UN","MASTER_ID":49088,"ec":"1.17.8.1","compounds":"FAD + H(+) + H2O + squalene = FADH2 + hydroxysqualene"}
{"X":40889,"RHEA_ID":39191,"compounds":"(2E)-docosenoyl-CoA + H(+) + NADPH = docosanoyl-CoA + NADP(+)"}
{"X":40890,"RHEA_ID":39192,"compounds":"(2E)-docosenoyl-CoA + H(+) + NADPH => docosanoyl-CoA + NADP(+)"}
{"X":40891,"RHEA_ID":39193,"compounds":"docosanoyl-CoA + NADP(+) => (2E)-docosenoyl-CoA + H(+) + NADPH"}
{"X":40892,"RHEA_ID":59131,"compounds":"(S)-2,3-diaminopropanoate + 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + ATP <=> 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + AMP + diphosphate"}
{"X":40893,"RHEA_ID":39195,"compounds":"3-oxotetracosanoyl-CoA + H(+) + NADPH = (3R)-hydroxytetracosanoyl-CoA + NADP(+)"}
{"X":40894,"RHEA_ID":39196,"compounds":"3-oxotetracosanoyl-CoA + H(+) + NADPH => (3R)-hydroxytetracosanoyl-CoA + NADP(+)"}
{"X":40895,"RHEA_ID":39197,"compounds":"(3R)-hydroxytetracosanoyl-CoA + NADP(+) => 3-oxotetracosanoyl-CoA + H(+) + NADPH"}
{"X":40896,"RHEA_ID":49096,"DIRECTION":"UN","MASTER_ID":49096,"ec":"1.21.98.3","compounds":"H2O + Mg-protoporphyrin IX 13-monomethyl ester + 3 S-adenosyl-L-methionine = 3,8-divinyl protochlorophyllide a + 3 5'-deoxyadenosine + 4 H(+) + 3 L-methionine"}
{"X":40897,"RHEA_ID":39199,"compounds":"(3R)-hydroxytetracosanoyl-CoA = (2E)-tetracosenoyl-CoA + H2O"}
{"X":40898,"RHEA_ID":39200,"compounds":"(3R)-hydroxytetracosanoyl-CoA => (2E)-tetracosenoyl-CoA + H2O"}
{"X":40899,"RHEA_ID":39201,"compounds":"(2E)-tetracosenoyl-CoA + H2O => (3R)-hydroxytetracosanoyl-CoA"}
{"X":40900,"RHEA_ID":42499,"compounds":"10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate <=> 10-deacetyl-2-debenzoylbaccatin III"}
{"X":40901,"RHEA_ID":39203,"compounds":"(2E)-tetracosenoyl-CoA + H(+) + NADPH = NADP(+) + tetracosanoyl-CoA"}
{"X":40902,"RHEA_ID":39204,"compounds":"(2E)-tetracosenoyl-CoA + H(+) + NADPH => NADP(+) + tetracosanoyl-CoA"}
{"X":40903,"RHEA_ID":39205,"compounds":"NADP(+) + tetracosanoyl-CoA => (2E)-tetracosenoyl-CoA + H(+) + NADPH"}
{"X":40904,"RHEA_ID":52486,"DIRECTION":"RL","MASTER_ID":52484,"metacyc":"RXN-18618","compounds":"(3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + AH2 => (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + A"}
{"X":40905,"RHEA_ID":39207,"compounds":"3-oxohexacosanoyl-CoA + H(+) + NADPH = (3R)-hydroxyhexacosanoyl-CoA + NADP(+)"}
{"X":40906,"RHEA_ID":39208,"compounds":"3-oxohexacosanoyl-CoA + H(+) + NADPH => (3R)-hydroxyhexacosanoyl-CoA + NADP(+)"}
{"X":40907,"RHEA_ID":39209,"compounds":"(3R)-hydroxyhexacosanoyl-CoA + NADP(+) => 3-oxohexacosanoyl-CoA + H(+) + NADPH"}
{"X":40908,"RHEA_ID":49108,"compounds":"Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine = 3,8-divinyl protochlorophyllide a + 5'-deoxyadenosine + 2 H(+) + L-methionine"}
{"X":40909,"RHEA_ID":39211,"compounds":"(3R)-hydroxyhexacosanoyl-CoA = (2E)-hexacosenoyl-CoA + H2O"}
{"X":40910,"RHEA_ID":39212,"compounds":"(3R)-hydroxyhexacosanoyl-CoA => (2E)-hexacosenoyl-CoA + H2O"}
{"X":40911,"RHEA_ID":39213,"compounds":"(2E)-hexacosenoyl-CoA + H2O => (3R)-hydroxyhexacosanoyl-CoA"}
{"X":40912,"RHEA_ID":39214,"compounds":"(3R)-hydroxyhexacosanoyl-CoA <=> (2E)-hexacosenoyl-CoA + H2O"}
{"X":40913,"RHEA_ID":39215,"compounds":"(2E)-hexacosenoyl-CoA + H(+) + NADPH = hexacosanoyl-CoA + NADP(+)"}
{"X":40914,"RHEA_ID":39216,"compounds":"(2E)-hexacosenoyl-CoA + H(+) + NADPH => hexacosanoyl-CoA + NADP(+)"}
{"X":40915,"RHEA_ID":39217,"compounds":"hexacosanoyl-CoA + NADP(+) => (2E)-hexacosenoyl-CoA + H(+) + NADPH"}
{"X":40916,"RHEA_ID":39218,"compounds":"(2E)-hexacosenoyl-CoA + H(+) + NADPH <=> hexacosanoyl-CoA + NADP(+)"}
{"X":40917,"RHEA_ID":39219,"compounds":"3-oxooctacosanyol-CoA + H(+) + NADPH = (3R)-hydroxyoctacosanoyl-CoA + NADP(+)"}
{"X":40918,"RHEA_ID":39220,"compounds":"3-oxooctacosanyol-CoA + H(+) + NADPH => (3R)-hydroxyoctacosanoyl-CoA + NADP(+)"}
{"X":40919,"RHEA_ID":39221,"compounds":"(3R)-hydroxyoctacosanoyl-CoA + NADP(+) => 3-oxooctacosanyol-CoA + H(+) + NADPH"}
{"X":40920,"RHEA_ID":49120,"DIRECTION":"UN","MASTER_ID":49120,"ec":"1.14.13.224","compounds":"H(+) + NADPH + O2 + protoviolaceinate = H2O + NADP(+) + violaceinate"}
{"X":40921,"RHEA_ID":39223,"compounds":"(3R)-hydroxyoctacosanoyl-CoA = (2E)-octacosenoyl-CoA + H2O"}
{"X":40922,"RHEA_ID":39224,"compounds":"(3R)-hydroxyoctacosanoyl-CoA => (2E)-octacosenoyl-CoA + H2O"}
{"X":40923,"RHEA_ID":39225,"compounds":"(2E)-octacosenoyl-CoA + H2O => (3R)-hydroxyoctacosanoyl-CoA"}
{"X":40924,"RHEA_ID":42523,"compounds":"23S rRNA uridine(2605) <=> 23S rRNA pseudouridine(2605)"}
{"X":40925,"RHEA_ID":39227,"compounds":"(2E)-octacosenoyl-CoA + H(+) + NADPH = NADP(+) + octacosanoyl-CoA"}
{"X":40926,"RHEA_ID":39228,"compounds":"(2E)-octacosenoyl-CoA + H(+) + NADPH => NADP(+) + octacosanoyl-CoA"}
{"X":40927,"RHEA_ID":39229,"compounds":"NADP(+) + octacosanoyl-CoA => (2E)-octacosenoyl-CoA + H(+) + NADPH"}
{"X":40928,"RHEA_ID":49128,"DIRECTION":"UN","MASTER_ID":49128,"ec":"2.1.1.326","compounds":"AH2 + N-acetyl-demethyl-L-phosphinothricin + 2 S-adenosyl-L-methionine = 5'-deoxyadenosine + A + 2 H(+) + L-methionine + N-acetyl-L-phosphinothricin + S-adenosyl-L-homocysteine"}
{"X":40929,"RHEA_ID":39231,"compounds":"3-oxo-triacontanoyl-CoA + H(+) + NADPH = (3R)-hydroxytriacontanoyl-CoA + NADP(+)"}
{"X":40930,"RHEA_ID":39232,"compounds":"3-oxo-triacontanoyl-CoA + H(+) + NADPH => (3R)-hydroxytriacontanoyl-CoA + NADP(+)"}
{"X":40931,"RHEA_ID":42530,"compounds":"pseudouridine(955/2504/2580) in 23S rRNA => uridine(955/2504/2580) in 23S rRNA"}
{"X":40932,"RHEA_ID":42531,"compounds":"uridine(955/2504/2580) in 23S rRNA <=> pseudouridine(955/2504/2580) in 23S rRNA"}
{"X":40933,"RHEA_ID":39235,"compounds":"(3R)-hydroxytriacontanoyl-CoA = (2E)-triacontenoyl-CoA + H2O"}
{"X":40934,"RHEA_ID":39236,"compounds":"(3R)-hydroxytriacontanoyl-CoA => (2E)-triacontenoyl-CoA + H2O"}
{"X":40935,"RHEA_ID":39237,"compounds":"(2E)-triacontenoyl-CoA + H2O => (3R)-hydroxytriacontanoyl-CoA"}
{"X":40936,"RHEA_ID":39238,"compounds":"(3R)-hydroxytriacontanoyl-CoA <=> (2E)-triacontenoyl-CoA + H2O"}
{"X":40937,"RHEA_ID":39239,"compounds":"(2E)-triacontenoyl-CoA + H(+) + NADPH = NADP(+) + triacontanoyl-CoA"}
{"X":40938,"RHEA_ID":39240,"compounds":"(2E)-triacontenoyl-CoA + H(+) + NADPH => NADP(+) + triacontanoyl-CoA"}
{"X":40939,"RHEA_ID":39241,"compounds":"NADP(+) + triacontanoyl-CoA => (2E)-triacontenoyl-CoA + H(+) + NADPH"}
{"X":40940,"RHEA_ID":42539,"DIRECTION":"BI","MASTER_ID":42536,"ecocyc":"RXN-11840","metacyc":"RXN-11840","compounds":"uridine(65) in tRNA <=> pseudouridine(65) in tRNA"}
{"X":40941,"RHEA_ID":39243,"compounds":"(11Z)-3-oxoicosenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(11Z)-eicosenoyl-CoA + NADP(+)"}
{"X":40942,"RHEA_ID":39244,"compounds":"(11Z)-3-oxoicosenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(11Z)-eicosenoyl-CoA + NADP(+)"}
{"X":40943,"RHEA_ID":49143,"compounds":"dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":40944,"RHEA_ID":49144,"DIRECTION":"UN","MASTER_ID":49144,"ec":"2.6.1.110","compounds":"2-oxoglutarate + dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose = dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + L-glutamate"}
{"X":40945,"RHEA_ID":39247,"compounds":"(3R)-hydroxy-(11Z)-eicosenoyl-CoA = (2E,11Z)-eicosadienoyl-CoA + H2O"}
{"X":40946,"RHEA_ID":39248,"compounds":"(3R)-hydroxy-(11Z)-eicosenoyl-CoA => (2E,11Z)-eicosadienoyl-CoA + H2O"}
{"X":40947,"RHEA_ID":59218,"compounds":"CO2 + skatole => (indol-3-yl)acetate + H(+)"}
{"X":40948,"RHEA_ID":49148,"DIRECTION":"UN","MASTER_ID":49148,"ec":"2.1.1.324","compounds":"dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + 2 S-adenosyl-L-methionine = dTDP-alpha-D-forosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine"}
{"X":40949,"RHEA_ID":39251,"compounds":"(2E,11Z)-eicosadienoyl-CoA + H(+) + NADPH = (11Z)-eicosenoyl-CoA + NADP(+)"}
{"X":40950,"RHEA_ID":39252,"compounds":"(2E,11Z)-eicosadienoyl-CoA + H(+) + NADPH => (11Z)-eicosenoyl-CoA + NADP(+)"}
{"X":40951,"RHEA_ID":39253,"compounds":"(11Z)-eicosenoyl-CoA + NADP(+) => (2E,11Z)-eicosadienoyl-CoA + H(+) + NADPH"}
{"X":40952,"RHEA_ID":59223,"compounds":"(2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate + H2O <=> (2Z)-2-hydroxypenta-2,4-dienoate + acetate + H(+)"}
{"X":40953,"RHEA_ID":39255,"compounds":"(13Z)-3-oxodocosenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(13Z)-docosenoyl-CoA + NADP(+)"}
{"X":40954,"RHEA_ID":39256,"compounds":"(13Z)-3-oxodocosenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(13Z)-docosenoyl-CoA + NADP(+)"}
{"X":40955,"RHEA_ID":39257,"compounds":"(3R)-hydroxy-(13Z)-docosenoyl-CoA + NADP(+) => (13Z)-3-oxodocosenoyl-CoA + H(+) + NADPH"}
{"X":40956,"RHEA_ID":59227,"compounds":"all-trans-geranylgeranyl diphosphate <=> diphosphate + hydropyrene"}
{"X":40957,"RHEA_ID":39259,"compounds":"(3R)-hydroxy-(13Z)-docosenoyl-CoA = (2E,13Z)-docosadienoyl-CoA + H2O"}
{"X":40958,"RHEA_ID":39260,"compounds":"(3R)-hydroxy-(13Z)-docosenoyl-CoA => (2E,13Z)-docosadienoyl-CoA + H2O"}
{"X":40959,"RHEA_ID":39261,"compounds":"(2E,13Z)-docosadienoyl-CoA + H2O => (3R)-hydroxy-(13Z)-docosenoyl-CoA"}
{"X":40960,"RHEA_ID":59231,"DIRECTION":"BI","MASTER_ID":59228,"metacyc":"RXN-20061","compounds":"6-sulfo-alpha-D-quinovose <=> 6-sulfo-beta-D-quinovose"}
{"X":40961,"RHEA_ID":39263,"compounds":"(2E,13Z)-docosadienoyl-CoA + H(+) + NADPH = (13Z)-docosenoyl-CoA + NADP(+)"}
{"X":40962,"RHEA_ID":39264,"compounds":"(2E,13Z)-docosadienoyl-CoA + H(+) + NADPH => (13Z)-docosenoyl-CoA + NADP(+)"}
{"X":40963,"RHEA_ID":39265,"compounds":"(13Z)-docosenoyl-CoA + NADP(+) => (2E,13Z)-docosadienoyl-CoA + H(+) + NADPH"}
{"X":40964,"RHEA_ID":49164,"compounds":"a bacteriochlorophyllide c + H2O + S-adenosyl-L-methionine = 5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide c + H(+) + L-methionine"}
{"X":40965,"RHEA_ID":39267,"compounds":"(15Z)-3-oxotetracosenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(15Z)-tetracosenoyl-CoA + NADP(+)"}
{"X":40966,"RHEA_ID":39268,"compounds":"(15Z)-3-oxotetracosenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(15Z)-tetracosenoyl-CoA + NADP(+)"}
{"X":40967,"RHEA_ID":39269,"compounds":"(3R)-hydroxy-(15Z)-tetracosenoyl-CoA + NADP(+) => (15Z)-3-oxotetracosenoyl-CoA + H(+) + NADPH"}
{"X":40968,"RHEA_ID":39270,"compounds":"(15Z)-3-oxotetracosenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(15Z)-tetracosenoyl-CoA + NADP(+)"}
{"X":40969,"RHEA_ID":49169,"DIRECTION":"LR","MASTER_ID":49168,"metacyc":"RXN-17430","compounds":"8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine => 8,12-diethyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine"}
{"X":40970,"RHEA_ID":39272,"compounds":"(3R)-hydroxy-(15Z)-tetracosenoyl-CoA => (2E,15Z)-tetracosadienoyl-CoA + H2O"}
{"X":40971,"RHEA_ID":39273,"compounds":"(2E,15Z)-tetracosadienoyl-CoA + H2O => (3R)-hydroxy-(15Z)-tetracosenoyl-CoA"}
{"X":40972,"RHEA_ID":52554,"compounds":"3-dehydro-4-O-phospho-L-erythronate + ADP + H(+) => 3-dehydro-L-erythronate + ATP"}
{"X":40973,"RHEA_ID":39275,"compounds":"(2E,15Z)-tetracosadienoyl-CoA + H(+) + NADPH = (15Z)-tetracosenoyl-CoA + NADP(+)"}
{"X":40974,"RHEA_ID":39276,"compounds":"(2E,15Z)-tetracosadienoyl-CoA + H(+) + NADPH => (15Z)-tetracosenoyl-CoA + NADP(+)"}
{"X":40975,"RHEA_ID":39277,"compounds":"(15Z)-tetracosenoyl-CoA + NADP(+) => (2E,15Z)-tetracosadienoyl-CoA + H(+) + NADPH"}
{"X":40976,"RHEA_ID":52558,"compounds":"3-dehydro-4-O-phospho-D-erythronate + ADP + H(+) => 3-dehydro-D-erythronate + ATP"}
{"X":40977,"RHEA_ID":39279,"compounds":"ATP + dodecanoate(out) + H2O = ADP + dodecanoate(in) + H(+) + phosphate"}
{"X":40978,"RHEA_ID":39280,"compounds":"ATP + dodecanoate(out) + H2O => ADP + dodecanoate(in) + H(+) + phosphate"}
{"X":40979,"RHEA_ID":39281,"compounds":"ADP + dodecanoate(in) + H(+) + phosphate => ATP + dodecanoate(out) + H2O"}
{"X":40980,"RHEA_ID":39282,"compounds":"ATP + dodecanoate(out) + H2O <=> ADP + dodecanoate(in) + H(+) + phosphate"}
{"X":40981,"RHEA_ID":39283,"compounds":"a long-chain fatty acid(out) = a long-chain fatty acid(in)"}
{"X":40982,"RHEA_ID":49182,"compounds":"a bacteriochlorophyllide c + H(+) + S-adenosyl-L-homocysteine => a bacteriochlorophyllide d + S-adenosyl-L-methionine"}
{"X":40983,"RHEA_ID":39285,"compounds":"a long-chain fatty acid(in) => a long-chain fatty acid(out)"}
{"X":40984,"RHEA_ID":49184,"DIRECTION":"UN","MASTER_ID":49184,"ec":"3.1.1.100","compounds":"chlorophyllide a + H(+) + H2O = 8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + CO2 + methanol"}
{"X":40985,"RHEA_ID":39287,"DIRECTION":"UN","MASTER_ID":39287,"ec":"2.1.1.250","compounds":"[Co(I) trimethylamine-specific corrinoid protein] + H(+) + trimethylamine = [methyl-Co(III) trimethylamine-specific corrinoid protein] + dimethylamine"}
{"X":40986,"RHEA_ID":39288,"DIRECTION":"LR","MASTER_ID":39287,"metacyc":"RXN-8102","compounds":"[Co(I) trimethylamine-specific corrinoid protein] + H(+) + trimethylamine => [methyl-Co(III) trimethylamine-specific corrinoid protein] + dimethylamine"}
{"X":40987,"RHEA_ID":59258,"compounds":"Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+) => Fe(III)-enterobactin + H2O"}
{"X":40988,"RHEA_ID":39291,"compounds":"(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + CO2 + CoA"}
{"X":40989,"RHEA_ID":39292,"compounds":"(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + CO2 + CoA"}
{"X":40990,"RHEA_ID":39293,"compounds":"3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + CO2 + CoA => (9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + H(+) + malonyl-CoA"}
{"X":40991,"RHEA_ID":42591,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":40992,"RHEA_ID":49193,"compounds":"calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 1alpha,23S,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]"}
{"X":40993,"RHEA_ID":39296,"compounds":"(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + AH2 + O2 => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + A + 2 H2O"}
{"X":40994,"RHEA_ID":39297,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + A + 2 H2O => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + AH2 + O2"}
{"X":40995,"RHEA_ID":49196,"compounds":"2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol = 25-hydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin]"}
{"X":40996,"RHEA_ID":39299,"compounds":"(11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA + NADP(+)"}
{"X":40997,"RHEA_ID":39300,"compounds":"(11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA + NADP(+)"}
{"X":40998,"RHEA_ID":39301,"compounds":"(3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA + NADP(+) => (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + H(+) + NADPH"}
{"X":40999,"RHEA_ID":39302,"compounds":"(11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA + NADP(+)"}
{"X":41000,"RHEA_ID":39303,"compounds":"(3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA = (2E,11Z,14Z)-eicosatrienoyl-CoA + H2O"}
{"X":41001,"RHEA_ID":39304,"compounds":"(3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA => (2E,11Z,14Z)-eicosatrienoyl-CoA + H2O"}
{"X":41002,"RHEA_ID":39305,"compounds":"(2E,11Z,14Z)-eicosatrienoyl-CoA + H2O => (3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA"}
{"X":41003,"RHEA_ID":49204,"compounds":"20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 20S,24R-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]"}
{"X":41004,"RHEA_ID":39307,"compounds":"(2E,11Z,14Z)-eicosatrienoyl-CoA + H(+) + NADPH = (11Z,14Z)-eicosadienoyl-CoA + NADP(+)"}
{"X":41005,"RHEA_ID":39308,"compounds":"(2E,11Z,14Z)-eicosatrienoyl-CoA + H(+) + NADPH => (11Z,14Z)-eicosadienoyl-CoA + NADP(+)"}
{"X":41006,"RHEA_ID":39309,"compounds":"(11Z,14Z)-eicosadienoyl-CoA + NADP(+) => (2E,11Z,14Z)-eicosatrienoyl-CoA + H(+) + NADPH"}
{"X":41007,"RHEA_ID":49208,"compounds":"20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 20S,24S-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]"}
{"X":41008,"RHEA_ID":39311,"compounds":"(8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+)"}
{"X":41009,"RHEA_ID":39312,"compounds":"(8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+)"}
{"X":41010,"RHEA_ID":39313,"compounds":"(3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+) => (8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH"}
{"X":41011,"RHEA_ID":39314,"compounds":"(8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+)"}
{"X":41012,"RHEA_ID":39315,"compounds":"(3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA = (2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O"}
{"X":41013,"RHEA_ID":39316,"compounds":"(3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA => (2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O"}
{"X":41014,"RHEA_ID":39317,"compounds":"(2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O => (3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA"}
{"X":41015,"RHEA_ID":39318,"compounds":"(3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA <=> (2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O"}
{"X":41016,"RHEA_ID":39319,"compounds":"(2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + NADPH = (8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+)"}
{"X":41017,"RHEA_ID":39320,"compounds":"(2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + NADPH => (8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+)"}
{"X":41018,"RHEA_ID":39321,"compounds":"(8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+) => (2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + NADPH"}
{"X":41019,"RHEA_ID":49220,"DIRECTION":"UN","MASTER_ID":49220,"ec":"2.7.7.92","compounds":"3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + CTP = CMP-beta-3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + diphosphate"}
{"X":41020,"RHEA_ID":39323,"compounds":"(7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+)"}
{"X":41021,"RHEA_ID":39324,"compounds":"(7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+)"}
{"X":41022,"RHEA_ID":39325,"compounds":"(3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+) => (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + H(+) + NADPH"}
{"X":41023,"RHEA_ID":52606,"compounds":"3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-6-O-phospho-alpha-D-mannosyl)-L-seryl-[protein] + ADP + H(+) => 3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-seryl-[protein] + ATP"}
{"X":41024,"RHEA_ID":39327,"compounds":"(3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA = (2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H2O"}
{"X":41025,"RHEA_ID":39328,"compounds":"(3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA => (2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H2O"}
{"X":41026,"RHEA_ID":39329,"compounds":"(2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H2O => (3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA"}
{"X":41027,"RHEA_ID":49228,"DIRECTION":"UN","MASTER_ID":49228,"ec":"2.5.1.133","compounds":"all-trans-geranylgeranyl diphosphate + bacteriochlorophyllide a + H(+) = diphosphate + geranylgeranyl-bacteriochlorophyllide a"}
{"X":41028,"RHEA_ID":39331,"compounds":"(2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H(+) + NADPH = (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+)"}
{"X":41029,"RHEA_ID":39332,"compounds":"(2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H(+) + NADPH => (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+)"}
{"X":41030,"RHEA_ID":39333,"compounds":"(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+) => (2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H(+) + NADPH"}
{"X":41031,"RHEA_ID":49232,"DIRECTION":"UN","MASTER_ID":49232,"ec":"2.7.1.191","compounds":"D-mannose(out) + N(pros)-phospho-L-histidyl-[protein] = D-mannose 6-phosphate(in) + L-histidyl-[protein]"}
{"X":41032,"RHEA_ID":39335,"compounds":"3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+)"}
{"X":41033,"RHEA_ID":39336,"compounds":"3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+)"}
{"X":41034,"RHEA_ID":39337,"compounds":"(3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+) => 3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + NADPH"}
{"X":41035,"RHEA_ID":39338,"compounds":"3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+)"}
{"X":41036,"RHEA_ID":49237,"DIRECTION":"LR","MASTER_ID":49236,"metacyc":"SUCROSEPHOSPHO-RXN","compounds":"N(pros)-phospho-L-histidyl-[protein](out) + sucrose => L-histidyl-[protein] + sucrose 6(G)-phosphate(in)"}
{"X":41037,"RHEA_ID":39340,"compounds":"(9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+)"}
{"X":41038,"RHEA_ID":39341,"compounds":"(3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+) => (9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + H(+) + NADPH"}
{"X":41039,"RHEA_ID":39342,"compounds":"(9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+)"}
{"X":41040,"RHEA_ID":49241,"DIRECTION":"LR","MASTER_ID":49240,"ecocyc":"TRANS-RXN-167","metacyc":"TRANS-RXN-167","compounds":"N(pros)-phospho-L-histidyl-[protein] + N-acetyl-D-glucosamine(out) => L-histidyl-[protein] + N-acetyl-D-glucosamine 6-phosphate(in)"}
{"X":41041,"RHEA_ID":39344,"compounds":"(3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA => (2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H2O"}
{"X":41042,"RHEA_ID":39345,"compounds":"(2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H2O => (3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA"}
{"X":41043,"RHEA_ID":42642,"compounds":"a menaquinol + H(+) + S-adenosyl-L-homocysteine => a 2-demethylmenaquinol + S-adenosyl-L-methionine"}
{"X":41044,"RHEA_ID":49245,"compounds":"NAD(+) + resolvin E1 => 18-oxo-resolvin E1 + H(+) + NADH"}
{"X":41045,"RHEA_ID":39348,"compounds":"(2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADPH => (9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+)"}
{"X":41046,"RHEA_ID":39349,"compounds":"(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+) => (2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADPH"}
{"X":41047,"RHEA_ID":39350,"compounds":"(2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADPH <=> (9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+)"}
{"X":41048,"RHEA_ID":49249,"DIRECTION":"LR","MASTER_ID":49248,"ecocyc":"TRANS-RXN-161","metacyc":"TRANS-RXN-161","compounds":"galactitol(out) + N(pros)-phospho-L-histidyl-[protein] => galactitol 1-phosphate(in) + L-histidyl-[protein]"}
{"X":41049,"RHEA_ID":39352,"compounds":"(3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA => (2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H2O"}
{"X":41050,"RHEA_ID":39353,"compounds":"(2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H2O => (3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA"}
{"X":41051,"RHEA_ID":39354,"compounds":"(3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA <=> (2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H2O"}
{"X":41052,"RHEA_ID":49253,"DIRECTION":"LR","MASTER_ID":49252,"ecocyc":"TRANS-RXN-158","metacyc":"RXN-15151","compounds":"D-fructose(out) + N(pros)-phospho-L-histidyl-[protein] => D-fructose 1-phosphate(in) + L-histidyl-[protein]"}
{"X":41053,"RHEA_ID":39356,"compounds":"(2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H(+) + NADPH => (11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+)"}
{"X":41054,"RHEA_ID":39357,"compounds":"(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+) => (2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H(+) + NADPH"}
{"X":41055,"RHEA_ID":39358,"compounds":"(2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H(+) + NADPH <=> (11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+)"}
{"X":41056,"RHEA_ID":49256,"DIRECTION":"UN","MASTER_ID":49256,"ec":"2.7.1.203","compounds":"2-amino-2-deoxy-D-gluconate(out) + N(pros)-phospho-L-histidyl-[protein] = 2-amino-2-deoxy-D-gluconate 6-phosphate(in) + L-histidyl-[protein]"}
{"X":41057,"RHEA_ID":39360,"compounds":"(13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+)"}
{"X":41058,"RHEA_ID":39361,"compounds":"(3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+) => (13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + H(+) + NADPH"}
{"X":41059,"RHEA_ID":39362,"compounds":"(13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+)"}
{"X":41060,"RHEA_ID":49260,"DIRECTION":"UN","MASTER_ID":49260,"ec":"2.7.1.204","compounds":"D-galactose(out) + N(pros)-phospho-L-histidyl-[protein] = D-galactose 6-phosphate(in) + L-histidyl-[protein]"}
{"X":41061,"RHEA_ID":39364,"compounds":"(3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA => (2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H2O"}
{"X":41062,"RHEA_ID":39365,"compounds":"(2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H2O => (3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA"}
{"X":41063,"RHEA_ID":39366,"compounds":"(3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA <=> (2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H2O"}
{"X":41064,"RHEA_ID":39367,"compounds":"(2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H(+) + NADPH = (13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+)"}
{"X":41065,"RHEA_ID":39368,"compounds":"(2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H(+) + NADPH => (13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+)"}
{"X":41066,"RHEA_ID":39369,"compounds":"(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+) => (2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H(+) + NADPH"}
{"X":41067,"RHEA_ID":39370,"compounds":"(2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H(+) + NADPH <=> (13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+)"}
{"X":41068,"RHEA_ID":49268,"compounds":"25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 23S,25-dihydroxy-24-oxocholecalciferol + H2O + 2 oxidized [adrenodoxin]"}
{"X":41069,"RHEA_ID":39372,"compounds":"3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+)"}
{"X":41070,"RHEA_ID":39373,"compounds":"(3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+) => 3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + NADPH"}
{"X":41071,"RHEA_ID":39374,"compounds":"3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+)"}
{"X":41072,"RHEA_ID":49272,"compounds":"alfacalcidol + O2 + reduced [NADPH--hemoprotein reductase] = calcitriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41073,"RHEA_ID":39376,"compounds":"(3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA => (2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H2O"}
{"X":41074,"RHEA_ID":39377,"compounds":"(2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H2O => (3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA"}
{"X":41075,"RHEA_ID":39378,"compounds":"(3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA <=> (2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H2O"}
{"X":41076,"RHEA_ID":49276,"compounds":"CTP + phytyl phosphate = CDP + phytyl diphosphate"}
{"X":41077,"RHEA_ID":39380,"compounds":"(2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H(+) + NADPH => (15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+)"}
{"X":41078,"RHEA_ID":39381,"compounds":"(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+) => (2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H(+) + NADPH"}
{"X":41079,"RHEA_ID":39382,"compounds":"(2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H(+) + NADPH <=> (15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+)"}
{"X":41080,"RHEA_ID":49280,"DIRECTION":"UN","MASTER_ID":49280,"ec":"1.14.14.20","compounds":"FADH2 + O2 + phenol = catechol + FAD + H(+) + H2O"}
{"X":41081,"RHEA_ID":39384,"compounds":"3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+)"}
{"X":41082,"RHEA_ID":39385,"compounds":"(3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+) => 3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + NADPH"}
{"X":41083,"RHEA_ID":39386,"compounds":"3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+)"}
{"X":41084,"RHEA_ID":39387,"compounds":"(3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA = (2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H2O"}
{"X":41085,"RHEA_ID":39388,"compounds":"(3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA => (2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H2O"}
{"X":41086,"RHEA_ID":39389,"compounds":"(2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H2O => (3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA"}
{"X":41087,"RHEA_ID":39390,"compounds":"(3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA <=> (2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H2O"}
{"X":41088,"RHEA_ID":49288,"DIRECTION":"UN","MASTER_ID":49288,"ec":"6.3.1.20","compounds":"(R)-lipoate + [lipoyl-carrier protein]-L-lysine + ATP = [lipoyl-carrier protein]-(R)-N(6)-lipoyl-L-lysine + AMP + diphosphate + H(+)"}
{"X":41089,"RHEA_ID":39392,"compounds":"(2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH => (17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+)"}
{"X":41090,"RHEA_ID":39393,"compounds":"(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+) => (2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH"}
{"X":41091,"RHEA_ID":59362,"compounds":"beta-alanine + L-histidine => carnosine + H2O"}
{"X":41092,"RHEA_ID":39395,"compounds":"3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+)"}
{"X":41093,"RHEA_ID":39396,"compounds":"3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+)"}
{"X":41094,"RHEA_ID":39397,"compounds":"(3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+) => 3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + NADPH"}
{"X":41095,"RHEA_ID":59366,"compounds":"1-octadecanoyl-sn-glycero-3-phosphoserine + 9,10-epoxyoctadecanoate + H(+) => 1-octadecanoyl-2-(9,10-epoxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O"}
{"X":41096,"RHEA_ID":49296,"DIRECTION":"UN","MASTER_ID":49296,"ec":"2.7.1.206","compounds":"keto-L-sorbose(out) + N(pros)-phospho-L-histidyl-[protein] = L-histidyl-[protein] + L-sorbose 1-phosphate(in)"}
{"X":41097,"RHEA_ID":39400,"compounds":"(3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA => (2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H2O"}
{"X":41098,"RHEA_ID":39401,"compounds":"(2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H2O => (3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA"}
{"X":41099,"RHEA_ID":39402,"compounds":"(3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA <=> (2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H2O"}
{"X":41100,"RHEA_ID":59371,"compounds":"1-octadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphoserine + 10-hydroxyoctadecanoate + H(+)"}
{"X":41101,"RHEA_ID":39404,"compounds":"(2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH => (19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+)"}
{"X":41102,"RHEA_ID":39405,"compounds":"(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+) => (2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH"}
{"X":41103,"RHEA_ID":39406,"compounds":"(2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH <=> (19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+)"}
{"X":41104,"RHEA_ID":59375,"compounds":"1-hexadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + 10-hydroxyoctadecanoate + H(+)"}
{"X":41105,"RHEA_ID":39408,"compounds":"3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+)"}
{"X":41106,"RHEA_ID":39409,"compounds":"(3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+) => 3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + NADPH"}
{"X":41107,"RHEA_ID":39410,"compounds":"3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+)"}
{"X":41108,"RHEA_ID":59379,"DIRECTION":"BI","MASTER_ID":59376,"metacyc":"RXN-20192","compounds":"4-amino-4-deoxychorismate <=> 4-amino-4-deoxyprephenate"}
{"X":41109,"RHEA_ID":39412,"compounds":"(3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA => (2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H2O"}
{"X":41110,"RHEA_ID":39413,"compounds":"(2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H2O => (3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA"}
{"X":41111,"RHEA_ID":39414,"compounds":"(3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA <=> (2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H2O"}
{"X":41112,"RHEA_ID":59383,"compounds":"4-amino-4-deoxyprephenate + NAD(+) <=> 3-(4-aminophenyl)pyruvate + CO2 + H(+) + NADH"}
{"X":41113,"RHEA_ID":39416,"compounds":"(2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH => (21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+)"}
{"X":41114,"RHEA_ID":39417,"compounds":"(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+) => (2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH"}
{"X":41115,"RHEA_ID":39418,"compounds":"(2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH <=> (21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+)"}
{"X":41116,"RHEA_ID":49316,"compounds":"beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (5R,6S)-5,6-epoxi-beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":41117,"RHEA_ID":39420,"compounds":"3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+)"}
{"X":41118,"RHEA_ID":39421,"compounds":"(3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+) => 3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + H(+) + NADPH"}
{"X":41119,"RHEA_ID":39422,"compounds":"3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+)"}
{"X":41120,"RHEA_ID":59391,"compounds":"a fatty acid ester + H2O <=> a fatty acid + an aliphatic alcohol + H(+)"}
{"X":41121,"RHEA_ID":39424,"compounds":"(3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA => (2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H2O"}
{"X":41122,"RHEA_ID":39425,"compounds":"(2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H2O => (3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA"}
{"X":41123,"RHEA_ID":39426,"compounds":"(3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA <=> (2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H2O"}
{"X":41124,"RHEA_ID":49324,"compounds":"(5R,6S)-5,6-epoxi-capsanthin = all-trans-capsorubin"}
{"X":41125,"RHEA_ID":39428,"compounds":"(2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH => (23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+)"}
{"X":41126,"RHEA_ID":49326,"compounds":"all-trans-capsorubin => (5R,6S)-5,6-epoxi-capsanthin"}
{"X":41127,"RHEA_ID":39430,"compounds":"(2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH <=> (23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+)"}
{"X":41128,"RHEA_ID":49328,"compounds":"2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spheroidene = 2-hydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":41129,"RHEA_ID":39432,"compounds":"1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":41130,"RHEA_ID":49330,"compounds":"2-hydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spheroidene"}
{"X":41131,"RHEA_ID":39434,"compounds":"1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":41132,"RHEA_ID":49332,"compounds":"2-hydroxyspheroidene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2,2-dihydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":41133,"RHEA_ID":39436,"compounds":"(11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+)"}
{"X":41134,"RHEA_ID":39437,"compounds":"(3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+) => (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH"}
{"X":41135,"RHEA_ID":39438,"compounds":"(11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+)"}
{"X":41136,"RHEA_ID":39439,"compounds":"(3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA = (2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H2O"}
{"X":41137,"RHEA_ID":39440,"compounds":"(3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA => (2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H2O"}
{"X":41138,"RHEA_ID":49338,"compounds":"H2O + spheroiden-2-one => 2,2-dihydroxyspheroidene"}
{"X":41139,"RHEA_ID":39442,"compounds":"(3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA <=> (2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H2O"}
{"X":41140,"RHEA_ID":39443,"compounds":"(2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + NADPH = (11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+)"}
{"X":41141,"RHEA_ID":39444,"compounds":"(2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + NADPH => (11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+)"}
{"X":41142,"RHEA_ID":49342,"compounds":"2-hydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin"}
{"X":41143,"RHEA_ID":39446,"compounds":"(2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + NADPH <=> (11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+)"}
{"X":41144,"RHEA_ID":39447,"compounds":"(8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+)"}
{"X":41145,"RHEA_ID":39448,"compounds":"(8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+)"}
{"X":41146,"RHEA_ID":39449,"compounds":"(3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+) => (8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + H(+) + NADPH"}
{"X":41147,"RHEA_ID":39450,"compounds":"(8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+)"}
{"X":41148,"RHEA_ID":39451,"compounds":"(3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA = (2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O"}
{"X":41149,"RHEA_ID":39452,"compounds":"(3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA => (2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O"}
{"X":41150,"RHEA_ID":39453,"compounds":"(2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O => (3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA"}
{"X":41151,"RHEA_ID":39454,"compounds":"(3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA <=> (2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O"}
{"X":41152,"RHEA_ID":39455,"compounds":"(2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + NADPH = (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+)"}
{"X":41153,"RHEA_ID":39456,"compounds":"(2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + NADPH => (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+)"}
{"X":41154,"RHEA_ID":39457,"compounds":"(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+) => (2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + NADPH"}
{"X":41155,"RHEA_ID":39458,"compounds":"(2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + NADPH <=> (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+)"}
{"X":41156,"RHEA_ID":39459,"compounds":"(7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+)"}
{"X":41157,"RHEA_ID":39460,"compounds":"(7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+)"}
{"X":41158,"RHEA_ID":49358,"compounds":"2',2'-dihydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2'-hydroxy-2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":41159,"RHEA_ID":39462,"compounds":"(7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+)"}
{"X":41160,"RHEA_ID":39463,"compounds":"(3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA = (2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O"}
{"X":41161,"RHEA_ID":39464,"compounds":"(3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA => (2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O"}
{"X":41162,"RHEA_ID":49362,"compounds":"2,2'-dioxospirilloxanthin + H2O => 2',2'-dihydroxy-2-oxospirilloxanthin"}
{"X":41163,"RHEA_ID":39466,"compounds":"(3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA <=> (2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O"}
{"X":41164,"RHEA_ID":39467,"compounds":"(2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + NADPH = (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+)"}
{"X":41165,"RHEA_ID":39468,"compounds":"(2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + NADPH => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+)"}
{"X":41166,"RHEA_ID":49366,"compounds":"17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + diphosphate => 17-(4-hydroxyphenyl)heptadecanoate + ATP + H(+)"}
{"X":41167,"RHEA_ID":39470,"compounds":"(2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + NADPH <=> (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+)"}
{"X":41168,"RHEA_ID":39471,"compounds":"(9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+)"}
{"X":41169,"RHEA_ID":39472,"compounds":"(9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+)"}
{"X":41170,"RHEA_ID":49370,"compounds":"19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + diphosphate => 19-(4-hydroxyphenyl)nonadecanoate + ATP + H(+)"}
{"X":41171,"RHEA_ID":39474,"compounds":"(9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+)"}
{"X":41172,"RHEA_ID":39475,"compounds":"(3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA = (2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H2O"}
{"X":41173,"RHEA_ID":39476,"compounds":"(3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA => (2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H2O"}
{"X":41174,"RHEA_ID":39477,"compounds":"(2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H2O => (3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA"}
{"X":41175,"RHEA_ID":39478,"compounds":"(3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA <=> (2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H2O"}
{"X":41176,"RHEA_ID":39479,"compounds":"(2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADPH = (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+)"}
{"X":41177,"RHEA_ID":39480,"compounds":"(2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADPH => (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+)"}
{"X":41178,"RHEA_ID":49378,"compounds":"12,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 12-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":41179,"RHEA_ID":39482,"compounds":"(2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADPH <=> (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+)"}
{"X":41180,"RHEA_ID":39483,"compounds":"3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+)"}
{"X":41181,"RHEA_ID":49381,"compounds":"5-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 5,20-dihydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41182,"RHEA_ID":39485,"compounds":"(3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+) => 3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + NADPH"}
{"X":41183,"RHEA_ID":39486,"compounds":"3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+)"}
{"X":41184,"RHEA_ID":39487,"compounds":"(3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA = (2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H2O"}
{"X":41185,"RHEA_ID":39488,"compounds":"(3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA => (2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H2O"}
{"X":41186,"RHEA_ID":49386,"compounds":"(12R),18-dihydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (12R)-hydroxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":41187,"RHEA_ID":39490,"compounds":"(3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA <=> (2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H2O"}
{"X":41188,"RHEA_ID":39491,"compounds":"(2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH = (11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+)"}
{"X":41189,"RHEA_ID":39492,"compounds":"(2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH => (11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+)"}
{"X":41190,"RHEA_ID":49390,"compounds":"H(+) + UDP + validamycin A => UDP-alpha-D-glucose + validoxylamine A"}
{"X":41191,"RHEA_ID":39494,"compounds":"(2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH <=> (11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+)"}
{"X":41192,"RHEA_ID":39495,"compounds":"3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+)"}
{"X":41193,"RHEA_ID":39496,"compounds":"3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+)"}
{"X":41194,"RHEA_ID":39497,"compounds":"(3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+) => 3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + NADPH"}
{"X":41195,"RHEA_ID":39498,"compounds":"3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+)"}
{"X":41196,"RHEA_ID":39499,"compounds":"(3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA = (2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H2O"}
{"X":41197,"RHEA_ID":49397,"compounds":"20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 20S,23,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]"}
{"X":41198,"RHEA_ID":49398,"compounds":"20S,23,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin] => 20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}
{"X":41199,"RHEA_ID":39502,"compounds":"(3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA <=> (2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H2O"}
{"X":41200,"RHEA_ID":39503,"compounds":"(2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH = (13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+)"}
{"X":41201,"RHEA_ID":39504,"compounds":"(2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH => (13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+)"}
{"X":41202,"RHEA_ID":49402,"compounds":"phosphate + validoxylamine A => H2O + validoxylamine A 7'-phosphate"}
{"X":41203,"RHEA_ID":39506,"compounds":"(2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH <=> (13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+)"}
{"X":41204,"RHEA_ID":39507,"compounds":"3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+)"}
{"X":41205,"RHEA_ID":39508,"compounds":"3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+)"}
{"X":41206,"RHEA_ID":39509,"compounds":"(3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+) => 3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + NADPH"}
{"X":41207,"RHEA_ID":49407,"DIRECTION":"BI","MASTER_ID":49404,"metacyc":"RXN-17501","compounds":"beta-D-mannopyranosyl-(1->2)-D-mannopyranose + phosphate <=> alpha-D-mannose 1-phosphate + D-mannose"}
{"X":41208,"RHEA_ID":39511,"compounds":"(3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA = (2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H2O"}
{"X":41209,"RHEA_ID":39512,"compounds":"(3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA => (2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H2O"}
{"X":41210,"RHEA_ID":49410,"compounds":"[(1->2)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate => [(1->2)-beta-D-mannosyl](n) + phosphate"}
{"X":41211,"RHEA_ID":39515,"compounds":"(2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH = (15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+)"}
{"X":41212,"RHEA_ID":39516,"compounds":"(2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH => (15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+)"}
{"X":41213,"RHEA_ID":49414,"compounds":"alpha-L-colitosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP + H(+) => beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-colitose"}
{"X":41214,"RHEA_ID":49415,"compounds":"beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-colitose <=> alpha-L-colitosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP + H(+)"}
{"X":41215,"RHEA_ID":39519,"compounds":"3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+)"}
{"X":41216,"RHEA_ID":39520,"compounds":"3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+)"}
{"X":41217,"RHEA_ID":39521,"compounds":"(3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+) => 3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH"}
{"X":41218,"RHEA_ID":59502,"compounds":"1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H(+) + phosphate => 5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O"}
{"X":41219,"RHEA_ID":39523,"compounds":"(3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA = (2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H2O"}
{"X":41220,"RHEA_ID":39524,"compounds":"(3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA => (2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H2O"}
{"X":41221,"RHEA_ID":49422,"compounds":"ADP + H(+) + valienone 7-phosphate => ATP + valienone"}
{"X":41222,"RHEA_ID":59506,"compounds":"[protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein] => cholesterol + glycyl-L-cysteinyl-[protein] + H(+)"}
{"X":41223,"RHEA_ID":39527,"compounds":"(2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH = (17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+)"}
{"X":41224,"RHEA_ID":39528,"compounds":"(2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH => (17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+)"}
{"X":41225,"RHEA_ID":49426,"compounds":"ADP + H(+) + validone 7-phosphate => ATP + validone"}
{"X":41226,"RHEA_ID":39530,"compounds":"(2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH <=> (17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+)"}
{"X":41227,"RHEA_ID":39531,"compounds":"3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+)"}
{"X":41228,"RHEA_ID":39532,"compounds":"3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+)"}
{"X":41229,"RHEA_ID":49430,"compounds":"CMP-5'-phosphonoformate + diphosphate => CTP + phosphonoformate"}
{"X":41230,"RHEA_ID":39534,"compounds":"3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+)"}
{"X":41231,"RHEA_ID":39535,"compounds":"(3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA = (2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H2O"}
{"X":41232,"RHEA_ID":39536,"compounds":"(3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA => (2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H2O"}
{"X":41233,"RHEA_ID":49434,"compounds":"choloyl-CoA + lithocholate => cholate + lithocholoyl-CoA"}
{"X":41234,"RHEA_ID":39538,"compounds":"(3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA <=> (2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H2O"}
{"X":41235,"RHEA_ID":39539,"compounds":"(2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH = (19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+)"}
{"X":41236,"RHEA_ID":39540,"compounds":"(2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH => (19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+)"}
{"X":41237,"RHEA_ID":39541,"compounds":"(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+) => (2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH"}
{"X":41238,"RHEA_ID":39542,"compounds":"(2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH <=> (19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+)"}
{"X":41239,"RHEA_ID":39543,"compounds":"3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+)"}
{"X":41240,"RHEA_ID":39544,"compounds":"3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+)"}
{"X":41241,"RHEA_ID":39545,"compounds":"(3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+) => 3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH"}
{"X":41242,"RHEA_ID":39546,"compounds":"3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+)"}
{"X":41243,"RHEA_ID":39547,"compounds":"(3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA = (2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H2O"}
{"X":41244,"RHEA_ID":39548,"compounds":"(3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA => (2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H2O"}
{"X":41245,"RHEA_ID":39549,"compounds":"(2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H2O => (3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA"}
{"X":41246,"RHEA_ID":39550,"compounds":"(3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA <=> (2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H2O"}
{"X":41247,"RHEA_ID":39551,"compounds":"(2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH = (21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+)"}
{"X":41248,"RHEA_ID":39552,"compounds":"(2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH => (21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+)"}
{"X":41249,"RHEA_ID":39553,"compounds":"(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+) => (2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH"}
{"X":41250,"RHEA_ID":59534,"compounds":"(S)-codamine + H(+) + S-adenosyl-L-homocysteine => (S)-reticuline + S-adenosyl-L-methionine"}
{"X":41251,"RHEA_ID":39555,"compounds":"3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+)"}
{"X":41252,"RHEA_ID":39556,"compounds":"3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+)"}
{"X":41253,"RHEA_ID":39557,"compounds":"(3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+) => 3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH"}
{"X":41254,"RHEA_ID":49455,"compounds":"a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H2O <=> 6-sulfo-D-quinovose + a 1,2-diacyl-sn-glycerol"}
{"X":41255,"RHEA_ID":39559,"compounds":"(3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA = (2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H2O"}
{"X":41256,"RHEA_ID":39560,"compounds":"(3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA => (2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H2O"}
{"X":41257,"RHEA_ID":39561,"compounds":"(2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H2O => (3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA"}
{"X":41258,"RHEA_ID":49459,"compounds":"(2S)-2-amino-4-deoxychorismate + H2O <=> (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate + pyruvate"}
{"X":41259,"RHEA_ID":39563,"compounds":"(2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H(+) + NADPH = (23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+)"}
{"X":41260,"RHEA_ID":39564,"compounds":"(2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H(+) + NADPH => (23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+)"}
{"X":41261,"RHEA_ID":39565,"compounds":"(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+) => (2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H(+) + NADPH"}
{"X":41262,"RHEA_ID":49463,"DIRECTION":"BI","MASTER_ID":49460,"metacyc":"RXN-8845","compounds":"(2Z,4E)-2-aminomuconate + H2O <=> (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NH4(+)"}
{"X":41263,"RHEA_ID":39567,"compounds":"(11Z,14Z)-eicosadienoyl-CoA + AH2 + O2 = (8Z,11Z,14Z)-eicosatrienoyl-CoA + A + 2 H2O"}
{"X":41264,"RHEA_ID":39568,"compounds":"(11Z,14Z)-eicosadienoyl-CoA + AH2 + O2 => (8Z,11Z,14Z)-eicosatrienoyl-CoA + A + 2 H2O"}
{"X":41265,"RHEA_ID":39569,"compounds":"(8Z,11Z,14Z)-eicosatrienoyl-CoA + A + 2 H2O => (11Z,14Z)-eicosadienoyl-CoA + AH2 + O2"}
{"X":41266,"RHEA_ID":59550,"compounds":"H2O2 + N,N',N''-triacetylchitotriono-1,5-lactone => N,N',N''-triacetylchitotriose + O2"}
{"X":41267,"RHEA_ID":39571,"compounds":"(11Z,14Z,17Z)-eicosatrienoyl-CoA + AH2 + O2 = (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + A + 2 H2O"}
{"X":41268,"RHEA_ID":39572,"compounds":"(11Z,14Z,17Z)-eicosatrienoyl-CoA + AH2 + O2 => (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + A + 2 H2O"}
{"X":41269,"RHEA_ID":39573,"compounds":"(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + A + 2 H2O => (11Z,14Z,17Z)-eicosatrienoyl-CoA + AH2 + O2"}
{"X":41270,"RHEA_ID":39574,"compounds":"(11Z,14Z,17Z)-eicosatrienoyl-CoA + AH2 + O2 <=> (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + A + 2 H2O"}
{"X":41271,"RHEA_ID":39575,"compounds":"3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+)"}
{"X":41272,"RHEA_ID":39576,"compounds":"3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+)"}
{"X":41273,"RHEA_ID":39577,"compounds":"(3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+) => 3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH"}
{"X":41274,"RHEA_ID":39578,"compounds":"3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+)"}
{"X":41275,"RHEA_ID":39579,"compounds":"(3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA = (2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H2O"}
{"X":41276,"RHEA_ID":49477,"DIRECTION":"LR","MASTER_ID":49476,"metacyc":"RXN-10855","compounds":"2 H2O + L-1-piperideine-6-carboxylate + NAD(+) => H(+) + L-2-aminoadipate + NADH"}
{"X":41277,"RHEA_ID":39581,"compounds":"(2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H2O => (3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA"}
{"X":41278,"RHEA_ID":39582,"compounds":"(3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA <=> (2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H2O"}
{"X":41279,"RHEA_ID":39583,"compounds":"(2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H(+) + NADPH = (8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+)"}
{"X":41280,"RHEA_ID":39584,"compounds":"(2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H(+) + NADPH => (8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+)"}
{"X":41281,"RHEA_ID":39585,"compounds":"(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+) => (2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H(+) + NADPH"}
{"X":41282,"RHEA_ID":39586,"compounds":"(2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H(+) + NADPH <=> (8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+)"}
{"X":41283,"RHEA_ID":39587,"compounds":"3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+)"}
{"X":41284,"RHEA_ID":39588,"compounds":"3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+)"}
{"X":41285,"RHEA_ID":39589,"compounds":"(3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+) => 3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH"}
{"X":41286,"RHEA_ID":39590,"compounds":"3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+)"}
{"X":41287,"RHEA_ID":39591,"compounds":"(3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA = (2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H2O"}
{"X":41288,"RHEA_ID":39592,"compounds":"(3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA => (2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H2O"}
{"X":41289,"RHEA_ID":39593,"compounds":"(2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H2O => (3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA"}
{"X":41290,"RHEA_ID":39594,"compounds":"(3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA <=> (2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H2O"}
{"X":41291,"RHEA_ID":39595,"compounds":"(2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H(+) + NADPH = (10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+)"}
{"X":41292,"RHEA_ID":49492,"compounds":"GDP-4-dehydro-alpha-D-rhamnose + L-glutamate = 2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + 2-oxoglutarate + H(+) + H2O"}
{"X":41293,"RHEA_ID":39597,"compounds":"(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+) => (2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H(+) + NADPH"}
{"X":41294,"RHEA_ID":39598,"compounds":"(2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H(+) + NADPH <=> (10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+)"}
{"X":41295,"RHEA_ID":39599,"compounds":"3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+)"}
{"X":41296,"RHEA_ID":49496,"compounds":"2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + H(+) = 2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane"}
{"X":41297,"RHEA_ID":39601,"compounds":"(3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+) => 3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH"}
{"X":41298,"RHEA_ID":39602,"compounds":"3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+)"}
{"X":41299,"RHEA_ID":39603,"compounds":"(3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA = (2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H2O"}
{"X":41300,"RHEA_ID":49500,"compounds":"2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane + H2O = GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+)"}
{"X":41301,"RHEA_ID":39605,"compounds":"(2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H2O => (3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA"}
{"X":41302,"RHEA_ID":39606,"compounds":"(3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA <=> (2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H2O"}
{"X":41303,"RHEA_ID":39607,"compounds":"(2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H(+) + NADPH = (12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+)"}
{"X":41304,"RHEA_ID":49504,"DIRECTION":"UN","MASTER_ID":49504,"ec":"4.2.1.166","compounds":"phosphinomethylmalate = phosphinomethylisomalate"}
{"X":41305,"RHEA_ID":39609,"compounds":"(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+) => (2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H(+) + NADPH"}
{"X":41306,"RHEA_ID":39610,"compounds":"(2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H(+) + NADPH <=> (12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+)"}
{"X":41307,"RHEA_ID":39611,"compounds":"3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+)"}
{"X":41308,"RHEA_ID":39612,"compounds":"3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+)"}
{"X":41309,"RHEA_ID":39613,"compounds":"(3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+) => 3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH"}
{"X":41310,"RHEA_ID":39614,"compounds":"3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+)"}
{"X":41311,"RHEA_ID":39615,"compounds":"(3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA = (2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H2O"}
{"X":41312,"RHEA_ID":42911,"compounds":"S-adenosyl-L-methionine + uridine(1939) in 23S rRNA <=> 5-methyluridine(1939) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":41313,"RHEA_ID":39617,"compounds":"(2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H2O => (3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA"}
{"X":41314,"RHEA_ID":39618,"compounds":"(3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA <=> (2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H2O"}
{"X":41315,"RHEA_ID":39619,"compounds":"(2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H(+) + NADPH = (14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+)"}
{"X":41316,"RHEA_ID":52902,"compounds":"15,17(3)-seco-F430-17(3)-acid + 3 A + ADP + phosphate => 3 AH2 + ATP + H2O + Ni-sirohydrochlorin a,c-diamide"}
{"X":41317,"RHEA_ID":39621,"compounds":"(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+) => (2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H(+) + NADPH"}
{"X":41318,"RHEA_ID":39622,"compounds":"(2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H(+) + NADPH <=> (14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+)"}
{"X":41319,"RHEA_ID":39623,"compounds":"3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+)"}
{"X":41320,"RHEA_ID":42919,"compounds":"adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine <=> 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine"}
{"X":41321,"RHEA_ID":39625,"compounds":"(3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+) => 3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH"}
{"X":41322,"RHEA_ID":39626,"compounds":"3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+)"}
{"X":41323,"RHEA_ID":39627,"compounds":"(3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA = (2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H2O"}
{"X":41324,"RHEA_ID":49524,"DIRECTION":"UN","MASTER_ID":49524,"ec":"1.14.11.51","compounds":"2-oxoglutarate + an N(6)-methyl-2'-deoxyadenosine in DNA + O2 = a 2'-deoxyadenosine in DNA + CO2 + formaldehyde + succinate"}
{"X":41325,"RHEA_ID":39629,"compounds":"(2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H2O => (3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA"}
{"X":41326,"RHEA_ID":39630,"compounds":"(3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA <=> (2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H2O"}
{"X":41327,"RHEA_ID":39631,"compounds":"(2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H(+) + NADPH = (16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+)"}
{"X":41328,"RHEA_ID":39632,"compounds":"(2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H(+) + NADPH => (16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+)"}
{"X":41329,"RHEA_ID":39633,"compounds":"(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+) => (2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H(+) + NADPH"}
{"X":41330,"RHEA_ID":39634,"compounds":"(2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H(+) + NADPH <=> (16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+)"}
{"X":41331,"RHEA_ID":39635,"compounds":"3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+)"}
{"X":41332,"RHEA_ID":49532,"DIRECTION":"UN","MASTER_ID":49532,"ec":"3.1.1.102","compounds":"4-[(2-hydroxyethoxy)carbonyl]benzoate + H2O = ethylene glycol + H(+) + terephthalate"}
{"X":41333,"RHEA_ID":39637,"compounds":"(3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+) => 3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH"}
{"X":41334,"RHEA_ID":39638,"compounds":"3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+)"}
{"X":41335,"RHEA_ID":39639,"compounds":"(3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA = (2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H2O"}
{"X":41336,"RHEA_ID":39640,"compounds":"(3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA => (2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H2O"}
{"X":41337,"RHEA_ID":49537,"DIRECTION":"LR","MASTER_ID":49536,"metacyc":"RXN-15571","compounds":"2-amino-2-deoxy-D-gluconate => (2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate + H2O"}
{"X":41338,"RHEA_ID":39642,"compounds":"(3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA <=> (2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H2O"}
{"X":41339,"RHEA_ID":39643,"compounds":"(2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H(+) + NADPH = (18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+)"}
{"X":41340,"RHEA_ID":39644,"compounds":"(2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H(+) + NADPH => (18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+)"}
{"X":41341,"RHEA_ID":49541,"DIRECTION":"LR","MASTER_ID":49540,"metacyc":"RXN-15572","compounds":"(2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate => (4S,5R)-4,5,6-trihydroxy-2-iminohexanoate"}
{"X":41342,"RHEA_ID":39646,"compounds":"(2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H(+) + NADPH <=> (18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+)"}
{"X":41343,"RHEA_ID":39647,"DIRECTION":"UN","MASTER_ID":39647,"ec":"4.3.1.30","compounds":"AH2 + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose + S-adenosyl-L-methionine = 5'-deoxyadenosine + A + dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + H(+) + L-methionine + NH4(+)"}
{"X":41344,"RHEA_ID":42942,"compounds":"5-methylcytidine(34) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine => cytidine(34) in tRNA precursor + S-adenosyl-L-methionine"}
{"X":41345,"RHEA_ID":49545,"DIRECTION":"LR","MASTER_ID":49544,"metacyc":"RXN-15573","compounds":"(4S,5R)-4,5,6-trihydroxy-2-iminohexanoate + H2O => 2-dehydro-3-deoxy-D-gluconate + NH4(+)"}
{"X":41346,"RHEA_ID":49546,"compounds":"2-dehydro-3-deoxy-D-gluconate + NH4(+) => (4S,5R)-4,5,6-trihydroxy-2-iminohexanoate + H2O"}
{"X":41347,"RHEA_ID":39651,"DIRECTION":"UN","MASTER_ID":39651,"ec":"3.7.1.21","compounds":"6-oxocyclohex-1-ene-1-carbonyl-CoA + 2 H2O = 3-hydroxy-6-carboxyhexanoyl-CoA + H(+)"}
{"X":41348,"RHEA_ID":39652,"compounds":"6-oxocyclohex-1-ene-1-carbonyl-CoA + 2 H2O => 3-hydroxy-6-carboxyhexanoyl-CoA + H(+)"}
{"X":41349,"RHEA_ID":49549,"DIRECTION":"LR","MASTER_ID":49548,"metacyc":"RXN-17630","compounds":"H2O + N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein] => H(+) + L-arginyl-[protein] + lactate"}
{"X":41350,"RHEA_ID":49550,"compounds":"H(+) + L-arginyl-[protein] + lactate => H2O + N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein]"}
{"X":41351,"RHEA_ID":39655,"compounds":"(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + AH2 + O2 = (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + A + 2 H2O"}
{"X":41352,"RHEA_ID":42950,"compounds":"5-methylcytidine(48) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(48) in tRNA + S-adenosyl-L-methionine"}
{"X":41353,"RHEA_ID":49553,"DIRECTION":"LR","MASTER_ID":49552,"metacyc":"RXN-17632","compounds":"H2O + N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein] => H(+) + L-lysyl-[protein] + lactate"}
{"X":41354,"RHEA_ID":39658,"compounds":"(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + AH2 + O2 <=> (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + A + 2 H2O"}
{"X":41355,"RHEA_ID":42953,"DIRECTION":"LR","MASTER_ID":42952,"metacyc":"RXN-11859","compounds":"cytidine(49) in tRNA + S-adenosyl-L-methionine => 5-methylcytidine(49) in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":41356,"RHEA_ID":42954,"compounds":"5-methylcytidine(49) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(49) in tRNA + S-adenosyl-L-methionine"}
{"X":41357,"RHEA_ID":49557,"DIRECTION":"LR","MASTER_ID":49556,"metacyc":"RXN-17634","compounds":"H2O + S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein] => H(+) + L-cysteinyl-[protein] + lactate"}
{"X":41358,"RHEA_ID":39662,"compounds":"3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine <=> 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine"}
{"X":41359,"RHEA_ID":39663,"DIRECTION":"UN","MASTER_ID":39663,"ec":"1.1.98.4","compounds":"a quinol + H(+) + oxidized coenzyme F420-(gamma-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-Glu)(n)"}
{"X":41360,"RHEA_ID":42958,"compounds":"5-methylcytidine(38) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(38) in tRNA + S-adenosyl-L-methionine"}
{"X":41361,"RHEA_ID":49561,"DIRECTION":"LR","MASTER_ID":49560,"metacyc":"RXN-17372","compounds":"D-sedoheptulose 7-phosphate => (R)-demethyl-4-deoxygadusol + H(+) + H2O + phosphate"}
{"X":41362,"RHEA_ID":49562,"compounds":"(R)-demethyl-4-deoxygadusol + H(+) + H2O + phosphate => D-sedoheptulose 7-phosphate"}
{"X":41363,"RHEA_ID":39667,"DIRECTION":"UN","MASTER_ID":39667,"ec":"1.1.98.5","compounds":"a secondary alcohol + H(+) + oxidized coenzyme F420-(gamma-Glu)(n) = a ketone + reduced coenzyme F420-(gamma-Glu)(n)"}
{"X":41364,"RHEA_ID":42962,"compounds":"NADH + 2 oxidized [nitric oxide reductase rubredoxin domain] => H(+) + NAD(+) + 2 reduced [nitric oxide reductase rubredoxin domain]"}
{"X":41365,"RHEA_ID":49565,"DIRECTION":"LR","MASTER_ID":49564,"metacyc":"RXN-17373","compounds":"D-sedoheptulose 7-phosphate => 2-epi-valiolone + phosphate"}
{"X":41366,"RHEA_ID":49566,"compounds":"2-epi-valiolone + phosphate => D-sedoheptulose 7-phosphate"}
{"X":41367,"RHEA_ID":39671,"compounds":"(9Z)-hexadecenoyl-CoA + AH2 + O2 = (9Z,12Z)-hexadecadienoyl-CoA + A + 2 H2O"}
{"X":41368,"RHEA_ID":42966,"compounds":"pseudouridine(54/55) in tRNA => uridine(54/55) in tRNA"}
{"X":41369,"RHEA_ID":39673,"compounds":"(9Z,12Z)-hexadecadienoyl-CoA + A + 2 H2O => (9Z)-hexadecenoyl-CoA + AH2 + O2"}
{"X":41370,"RHEA_ID":39674,"compounds":"(9Z)-hexadecenoyl-CoA + AH2 + O2 <=> (9Z,12Z)-hexadecadienoyl-CoA + A + 2 H2O"}
{"X":41371,"RHEA_ID":39675,"compounds":"(9Z)-hexadecenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoA"}
{"X":41372,"RHEA_ID":39676,"compounds":"(9Z)-hexadecenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoA"}
{"X":41373,"RHEA_ID":49573,"compounds":"Fe-coproporphyrin III + 2 H(+) => coproporphyrin III + Fe(2+)"}
{"X":41374,"RHEA_ID":39678,"compounds":"(9Z)-hexadecenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoA"}
{"X":41375,"RHEA_ID":39679,"compounds":"(11Z)-octadecenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(13Z)-eicosenoyl-CoA + CO2 + CoA"}
{"X":41376,"RHEA_ID":42974,"compounds":"a cardiolipin + ethanolamine => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine"}
{"X":41377,"RHEA_ID":39681,"compounds":"3-oxo-(13Z)-eicosenoyl-CoA + CO2 + CoA => (11Z)-octadecenoyl-CoA + H(+) + malonyl-CoA"}
{"X":41378,"RHEA_ID":39682,"compounds":"(11Z)-octadecenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(13Z)-eicosenoyl-CoA + CO2 + CoA"}
{"X":41379,"RHEA_ID":39683,"compounds":"3-oxo-(11Z)-octadecenoyl-CoA + H(+) + NADPH = (R)-3-hydroxy-(11Z)-octadecenoyl-CoA + NADP(+)"}
{"X":41380,"RHEA_ID":39684,"compounds":"3-oxo-(11Z)-octadecenoyl-CoA + H(+) + NADPH => (R)-3-hydroxy-(11Z)-octadecenoyl-CoA + NADP(+)"}
{"X":41381,"RHEA_ID":49581,"DIRECTION":"LR","MASTER_ID":49580,"ecocyc":"RXN-17809","metacyc":"RXN-17809","compounds":"(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate => cyclic pyranopterin phosphate + diphosphate"}
{"X":41382,"RHEA_ID":39686,"compounds":"3-oxo-(11Z)-octadecenoyl-CoA + H(+) + NADPH <=> (R)-3-hydroxy-(11Z)-octadecenoyl-CoA + NADP(+)"}
{"X":41383,"RHEA_ID":39687,"compounds":"(R)-3-hydroxy-(11Z)-octadecenoyl-CoA = (2E,11Z)-octadecadienoyl-CoA + H2O"}
{"X":41384,"RHEA_ID":39688,"compounds":"(R)-3-hydroxy-(11Z)-octadecenoyl-CoA => (2E,11Z)-octadecadienoyl-CoA + H2O"}
{"X":41385,"RHEA_ID":49585,"compounds":"D-erythrulose 1-phosphate => L-erythrulose 1-phosphate"}
{"X":41386,"RHEA_ID":39690,"compounds":"(R)-3-hydroxy-(11Z)-octadecenoyl-CoA <=> (2E,11Z)-octadecadienoyl-CoA + H2O"}
{"X":41387,"RHEA_ID":39691,"compounds":"(2E,11Z)-octadecadienoyl-CoA + H(+) + NADPH = (11Z)-octadecenoyl-CoA + NADP(+)"}
{"X":41388,"RHEA_ID":42986,"compounds":"diphosphate + pimara-8(14),15-diene => (+)-copalyl diphosphate"}
{"X":41389,"RHEA_ID":39693,"compounds":"(11Z)-octadecenoyl-CoA + NADP(+) => (2E,11Z)-octadecadienoyl-CoA + H(+) + NADPH"}
{"X":41390,"RHEA_ID":39694,"compounds":"(2E,11Z)-octadecadienoyl-CoA + H(+) + NADPH <=> (11Z)-octadecenoyl-CoA + NADP(+)"}
{"X":41391,"RHEA_ID":39695,"compounds":"3-oxo-(13Z)-eicosenoyl-CoA + H(+) + NADPH = (R)-3-hydroxy-(13Z)-eicosenoyl-CoA + NADP(+)"}
{"X":41392,"RHEA_ID":39696,"compounds":"3-oxo-(13Z)-eicosenoyl-CoA + H(+) + NADPH => (R)-3-hydroxy-(13Z)-eicosenoyl-CoA + NADP(+)"}
{"X":41393,"RHEA_ID":49593,"compounds":"2-hydroxyisobutanoyl-CoA => (3S)-hydroxybutanoyl-CoA"}
{"X":41394,"RHEA_ID":39698,"compounds":"3-oxo-(13Z)-eicosenoyl-CoA + H(+) + NADPH <=> (R)-3-hydroxy-(13Z)-eicosenoyl-CoA + NADP(+)"}
{"X":41395,"RHEA_ID":39699,"compounds":"(R)-3-hydroxy-(13Z)-eicosenoyl-CoA = (2E,13Z)-eicosadienoyl-CoA + H2O"}
{"X":41396,"RHEA_ID":39700,"compounds":"(R)-3-hydroxy-(13Z)-eicosenoyl-CoA => (2E,13Z)-eicosadienoyl-CoA + H2O"}
{"X":41397,"RHEA_ID":39701,"compounds":"(2E,13Z)-eicosadienoyl-CoA + H2O => (R)-3-hydroxy-(13Z)-eicosenoyl-CoA"}
{"X":41398,"RHEA_ID":39702,"compounds":"(R)-3-hydroxy-(13Z)-eicosenoyl-CoA <=> (2E,13Z)-eicosadienoyl-CoA + H2O"}
{"X":41399,"RHEA_ID":39703,"compounds":"(2E,13Z)-eicosadienoyl-CoA + H(+) + NADPH = (13Z)-eicosenoyl-CoA + NADP(+)"}
{"X":41400,"RHEA_ID":39704,"compounds":"(2E,13Z)-eicosadienoyl-CoA + H(+) + NADPH => (13Z)-eicosenoyl-CoA + NADP(+)"}
{"X":41401,"RHEA_ID":49601,"compounds":"ATP + CoA + octanedioate => AMP + diphosphate + octanedioyl-CoA"}
{"X":41402,"RHEA_ID":39706,"compounds":"(2E,13Z)-eicosadienoyl-CoA + H(+) + NADPH <=> (13Z)-eicosenoyl-CoA + NADP(+)"}
{"X":41403,"RHEA_ID":39707,"compounds":"a long-chain fatty acyl-CoA(out) = a long-chain fatty acyl-CoA(in)"}
{"X":41404,"RHEA_ID":39708,"compounds":"a long-chain fatty acyl-CoA(out) => a long-chain fatty acyl-CoA(in)"}
{"X":41405,"RHEA_ID":49605,"DIRECTION":"LR","MASTER_ID":49604,"metacyc":"RXN-17593","compounds":"2-glutathionyl-2-methylbut-3-en-1-ol + NAD(+) => 2-glutathionyl-2-methylbut-3-enal + H(+) + NADH"}
{"X":41406,"RHEA_ID":39710,"compounds":"a long-chain fatty acyl-CoA(out) <=> a long-chain fatty acyl-CoA(in)"}
{"X":41407,"RHEA_ID":39711,"DIRECTION":"UN","MASTER_ID":39711,"ec":"1.5.3.22","compounds":"O2 + 2 reduced coenzyme F420-(gamma-Glu)(n) = 2 H(+) + 2 H2O + 2 oxidized coenzyme F420-(gamma-Glu)(n)"}
{"X":41408,"RHEA_ID":39712,"compounds":"O2 + 2 reduced coenzyme F420-(gamma-Glu)(n) => 2 H(+) + 2 H2O + 2 oxidized coenzyme F420-(gamma-Glu)(n)"}
{"X":41409,"RHEA_ID":39713,"compounds":"2 H(+) + 2 H2O + 2 oxidized coenzyme F420-(gamma-Glu)(n) => O2 + 2 reduced coenzyme F420-(gamma-Glu)(n)"}
{"X":41410,"RHEA_ID":59704,"compounds":"D-cellohexaono-1,5-lactone + H2O = D-cellohexaonate + H(+)"}
{"X":41411,"RHEA_ID":39715,"compounds":"(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + AH2 + O2 = (6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + A + 2 H2O"}
{"X":41412,"RHEA_ID":39716,"compounds":"(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + AH2 + O2 => (6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + A + 2 H2O"}
{"X":41413,"RHEA_ID":39717,"compounds":"(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + A + 2 H2O => (9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + AH2 + O2"}
{"X":41414,"RHEA_ID":49614,"compounds":"2-oxoglutarate + H(+) + NADH => (R)-2-hydroxyglutarate + NAD(+)"}
{"X":41415,"RHEA_ID":39719,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + tetracosanoate = 24-hydroxytetracosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41416,"RHEA_ID":39720,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + tetracosanoate => 24-hydroxytetracosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41417,"RHEA_ID":39721,"compounds":"24-hydroxytetracosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetracosanoate"}
{"X":41418,"RHEA_ID":49618,"compounds":"2-hydroxy-2-methylpropanoate + 2 H(+) + NADH => 2-hydroxy-2-methylpropanal + H2O + NAD(+)"}
{"X":41419,"RHEA_ID":39723,"compounds":"a 1,2-diacyl-sn-glycerol(in) = a 1,2-diacyl-sn-glycerol(out)"}
{"X":41420,"RHEA_ID":39724,"compounds":"a 1,2-diacyl-sn-glycerol(in) => a 1,2-diacyl-sn-glycerol(out)"}
{"X":41421,"RHEA_ID":39725,"compounds":"a 1,2-diacyl-sn-glycerol(out) => a 1,2-diacyl-sn-glycerol(in)"}
{"X":41422,"RHEA_ID":49622,"compounds":"D-erythrulose 1-phosphate + H(+) + NADPH => D-erythritol 1-phosphate + NADP(+)"}
{"X":41423,"RHEA_ID":39727,"compounds":"sphingomyelin(in) = sphingomyelin(out)"}
{"X":41424,"RHEA_ID":39728,"compounds":"sphingomyelin(in) => sphingomyelin(out)"}
{"X":41425,"RHEA_ID":39729,"compounds":"sphingomyelin(out) => sphingomyelin(in)"}
{"X":41426,"RHEA_ID":49626,"compounds":"ADP + D-erythritol 1-phosphate + H(+) => ATP + erythritol"}
{"X":41427,"RHEA_ID":39731,"compounds":"3-hydroxyhexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 3,16-dihydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41428,"RHEA_ID":39732,"compounds":"3-hydroxyhexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 3,16-dihydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41429,"RHEA_ID":39733,"compounds":"3,16-dihydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-hydroxyhexadecanoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":41430,"RHEA_ID":39734,"compounds":"3-hydroxyhexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 3,16-dihydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41431,"RHEA_ID":39735,"compounds":"3-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 3,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41432,"RHEA_ID":39736,"compounds":"3-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 3,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41433,"RHEA_ID":39737,"compounds":"3,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":41434,"RHEA_ID":49634,"compounds":"(3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + diphosphate + H(+) => (2E,6E)-farnesyl diphosphate + 3,5-dimethylorsellinate"}
{"X":41435,"RHEA_ID":39739,"compounds":"3-hydroxydodecanoate + H(+) + NADPH + O2 = 3,12-dihydroxydodecanoate + H2O + NADP(+)"}
{"X":41436,"RHEA_ID":39740,"compounds":"3-hydroxydodecanoate + H(+) + NADPH + O2 => 3,12-dihydroxydodecanoate + H2O + NADP(+)"}
{"X":41437,"RHEA_ID":39741,"compounds":"3,12-dihydroxydodecanoate + H2O + NADP(+) => 3-hydroxydodecanoate + H(+) + NADPH + O2"}
{"X":41438,"RHEA_ID":49638,"compounds":"H(+) + H2O2 + pyruvate => H2O + methylglyoxal + O2"}
{"X":41439,"RHEA_ID":39743,"compounds":"1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out)"}
{"X":41440,"RHEA_ID":39744,"compounds":"1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out)"}
{"X":41441,"RHEA_ID":39745,"compounds":"1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in)"}
{"X":41442,"RHEA_ID":39746,"compounds":"1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out)"}
{"X":41443,"RHEA_ID":39747,"compounds":"cholesterol(in) = cholesterol(out)"}
{"X":41444,"RHEA_ID":39748,"DIRECTION":"LR","MASTER_ID":39747,"reactome":"R-HSA-265443.1","compounds":"cholesterol(in) => cholesterol(out)"}
{"X":41445,"RHEA_ID":39748,"DIRECTION":"LR","MASTER_ID":39747,"reactome":"R-HSA-8951850.1","compounds":"cholesterol(in) => cholesterol(out)"}
{"X":41446,"RHEA_ID":49670,"compounds":"deoxyviolaceinate + H2O + NAD(+) => H(+) + NADH + O2 + protodeoxyviolaceinate"}
{"X":41447,"RHEA_ID":39750,"compounds":"cholesterol(in) <=> cholesterol(out)"}
{"X":41448,"RHEA_ID":39751,"compounds":"dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 11-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41449,"RHEA_ID":39752,"compounds":"dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 11-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41450,"RHEA_ID":49678,"compounds":"H2O + L-methionyl(47)-(R)-S-oxide-[F-actin] + NADP(+) => H(+) + L-methionyl(47)-[F-actin] + NADPH + O2"}
{"X":41451,"RHEA_ID":39754,"compounds":"dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41452,"RHEA_ID":39755,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41453,"RHEA_ID":39756,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41454,"RHEA_ID":49686,"compounds":"benzene-1,2,4-triol + H2O + NAD(+) => H(+) + NADH + O2 + resorcinol"}
{"X":41455,"RHEA_ID":39758,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41456,"RHEA_ID":39759,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41457,"RHEA_ID":39760,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41458,"RHEA_ID":49710,"compounds":"H(+) + isonocardicin C + S-methyl-5'-thioadenosine => nocardicin G + S-adenosyl-L-methionine"}
{"X":41459,"RHEA_ID":39762,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41460,"RHEA_ID":39767,"compounds":"20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41461,"RHEA_ID":39768,"compounds":"20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41462,"RHEA_ID":39769,"compounds":"20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":41463,"RHEA_ID":39770,"compounds":"20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41464,"RHEA_ID":39771,"compounds":"20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41465,"RHEA_ID":39772,"compounds":"20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41466,"RHEA_ID":39773,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":41467,"RHEA_ID":39774,"compounds":"20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41468,"RHEA_ID":39775,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 17,18-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41469,"RHEA_ID":39776,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 17,18-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41470,"RHEA_ID":39777,"compounds":"17,18-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":41471,"RHEA_ID":39778,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 17,18-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41472,"RHEA_ID":39779,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41473,"RHEA_ID":39780,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41474,"RHEA_ID":39781,"compounds":"(17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":41475,"RHEA_ID":39782,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41476,"RHEA_ID":49736,"DIRECTION":"UN","MASTER_ID":49736,"ec":"1.14.13.224","compounds":"2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate = CO2 + deoxyviolacein + 2 H2O + NAD(+)"}
{"X":41477,"RHEA_ID":39784,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => (17S,18R)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41478,"RHEA_ID":39785,"compounds":"(17S,18R)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":41479,"RHEA_ID":39786,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (17S,18R)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41480,"RHEA_ID":49740,"DIRECTION":"UN","MASTER_ID":49740,"ec":"1.14.13.224","compounds":"2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate = CO2 + deoxyviolacein + 2 H2O + NADP(+)"}
{"X":41481,"RHEA_ID":39788,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41482,"RHEA_ID":39789,"compounds":"19-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":41483,"RHEA_ID":39790,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41484,"RHEA_ID":49744,"DIRECTION":"UN","MASTER_ID":49744,"ec":"1.14.13.224","compounds":"deoxyviolaceinate + H(+) + O2 = CO2 + deoxyviolacein + H2O"}
{"X":41485,"RHEA_ID":39792,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41486,"RHEA_ID":39793,"compounds":"20-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":41487,"RHEA_ID":39794,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41488,"RHEA_ID":49748,"DIRECTION":"UN","MASTER_ID":49748,"ec":"1.14.13.217","compounds":"2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate = CO2 + 2 H2O + NADP(+) + proviolacein"}
{"X":41489,"RHEA_ID":39796,"compounds":"7beta-hydroxycholesterol(in) + ATP + H2O => 7beta-hydroxycholesterol(out) + ADP + H(+) + phosphate"}
{"X":41490,"RHEA_ID":39797,"compounds":"7beta-hydroxycholesterol(out) + ADP + H(+) + phosphate => 7beta-hydroxycholesterol(in) + ATP + H2O"}
{"X":41491,"RHEA_ID":39798,"compounds":"7beta-hydroxycholesterol(in) + ATP + H2O <=> 7beta-hydroxycholesterol(out) + ADP + H(+) + phosphate"}
{"X":41492,"RHEA_ID":49752,"DIRECTION":"UN","MASTER_ID":49752,"ec":"1.14.13.217","compounds":"2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate = CO2 + 2 H2O + NAD(+) + proviolacein"}
{"X":41493,"RHEA_ID":39800,"compounds":"20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + NAD(+) => 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + NADH"}
{"X":41494,"RHEA_ID":39801,"compounds":"20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + NADH => 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + NAD(+)"}
{"X":41495,"RHEA_ID":39802,"compounds":"20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + NAD(+) <=> 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + NADH"}
{"X":41496,"RHEA_ID":39803,"compounds":"20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O + NAD(+) = (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + NADH"}
{"X":41497,"RHEA_ID":39804,"compounds":"20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O + NAD(+) => (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + NADH"}
{"X":41498,"RHEA_ID":39805,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + NADH => 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O + NAD(+)"}
{"X":41499,"RHEA_ID":39806,"compounds":"20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O + NAD(+) <=> (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + NADH"}
{"X":41500,"RHEA_ID":49760,"compounds":"EDTA + FMNH2 + O2 = ethylenediaminetriacetate + FMN + glyoxylate + 2 H(+) + H2O"}
{"X":41501,"RHEA_ID":39808,"compounds":"octadecanoate(in) => octadecanoate(out)"}
{"X":41502,"RHEA_ID":39809,"compounds":"octadecanoate(out) => octadecanoate(in)"}
{"X":41503,"RHEA_ID":39810,"compounds":"octadecanoate(in) <=> octadecanoate(out)"}
{"X":41504,"RHEA_ID":39811,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41505,"RHEA_ID":39812,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41506,"RHEA_ID":49766,"compounds":"ethylenediaminediacetate + FMN + glyoxylate + H(+) + H2O => ethylenediaminetriacetate + FMNH2 + O2"}
{"X":41507,"RHEA_ID":39814,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41508,"RHEA_ID":49772,"compounds":"glycine + hexacosanoyl-CoA = CoA + H(+) + N-hexacosanoylglycine"}
{"X":41509,"RHEA_ID":39816,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + octadecanoate => 2-hydroxyoctadecanoate + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":41510,"RHEA_ID":49774,"compounds":"CoA + H(+) + N-hexacosanoylglycine => glycine + hexacosanoyl-CoA"}
{"X":41511,"RHEA_ID":39818,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + octadecanoate <=> 2-hydroxyoctadecanoate + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":41512,"RHEA_ID":49780,"compounds":"docosanoyl-CoA + glycine = CoA + H(+) + N-docosanoylglycine"}
{"X":41513,"RHEA_ID":39820,"compounds":"2 [Fe(II)-cytochrome b5] + docosanoate + 2 H(+) + O2 => 2-hydroxydocosanoate + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":41514,"RHEA_ID":39821,"compounds":"2-hydroxydocosanoate + 2 [Fe(III)-cytochrome b5] + H2O => 2 [Fe(II)-cytochrome b5] + docosanoate + 2 H(+) + O2"}
{"X":41515,"RHEA_ID":39822,"compounds":"2 [Fe(II)-cytochrome b5] + docosanoate + 2 H(+) + O2 <=> 2-hydroxydocosanoate + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":41516,"RHEA_ID":49784,"compounds":"chenodeoxycholoyl-CoA + taurine = CoA + H(+) + taurochenodeoxycholate"}
{"X":41517,"RHEA_ID":39824,"compounds":"2 [Fe(II)-cytochrome b5] + eicosanoate + 2 H(+) + O2 => 2-hydroxyeicosanoate + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":41518,"RHEA_ID":39825,"compounds":"2-hydroxyeicosanoate + 2 [Fe(III)-cytochrome b5] + H2O => 2 [Fe(II)-cytochrome b5] + eicosanoate + 2 H(+) + O2"}
{"X":41519,"RHEA_ID":39826,"compounds":"2 [Fe(II)-cytochrome b5] + eicosanoate + 2 H(+) + O2 <=> 2-hydroxyeicosanoate + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":41520,"RHEA_ID":49788,"compounds":"chenodeoxycholoyl-CoA + glycine = CoA + glycochenodeoxycholate + H(+)"}
{"X":41521,"RHEA_ID":39828,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + tetracosanoate => 2-hydroxytetracosanoate + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":41522,"RHEA_ID":39829,"compounds":"2-hydroxytetracosanoate + 2 [Fe(III)-cytochrome b5] + H2O => 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + tetracosanoate"}
{"X":41523,"RHEA_ID":39830,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + tetracosanoate <=> 2-hydroxytetracosanoate + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":41524,"RHEA_ID":49792,"compounds":"eicosanoyl-CoA + glycine = CoA + H(+) + N-eicosanoylglycinate"}
{"X":41525,"RHEA_ID":39832,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoate + O2 => 2-hydroxyhexadecanoate + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":41526,"RHEA_ID":39833,"compounds":"2-hydroxyhexadecanoate + 2 [Fe(III)-cytochrome b5] + H2O => 2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoate + O2"}
{"X":41527,"RHEA_ID":39834,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoate + O2 <=> 2-hydroxyhexadecanoate + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":41528,"RHEA_ID":49796,"compounds":"an N-acylglycine + H2O = a fatty acid + glycine"}
{"X":41529,"RHEA_ID":39836,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 1-(9Z-octadecenoyl)-sn-glycerol + phosphate"}
{"X":41530,"RHEA_ID":39837,"compounds":"1-(9Z-octadecenoyl)-sn-glycerol + phosphate => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O"}
{"X":41531,"RHEA_ID":39838,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 1-(9Z-octadecenoyl)-sn-glycerol + phosphate"}
{"X":41532,"RHEA_ID":49804,"DIRECTION":"UN","MASTER_ID":49804,"ec":"1.14.14.30","compounds":"2-methylpropan-1-amine + FMNH2 + O2 = FMN + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine"}
{"X":41533,"RHEA_ID":39840,"compounds":"a 2,3-diacyl-sn-glycerol + an acyl-CoA => a triacyl-sn-glycerol + CoA"}
{"X":41534,"RHEA_ID":39841,"compounds":"a triacyl-sn-glycerol + CoA => a 2,3-diacyl-sn-glycerol + an acyl-CoA"}
{"X":41535,"RHEA_ID":39842,"compounds":"a 2,3-diacyl-sn-glycerol + an acyl-CoA <=> a triacyl-sn-glycerol + CoA"}
{"X":41536,"RHEA_ID":49808,"DIRECTION":"UN","MASTER_ID":49808,"ec":"1.1.5.11","compounds":"a quinone + butan-1-ol = a quinol + butanal"}
{"X":41537,"RHEA_ID":39844,"compounds":"1,3-diacyl-sn-glycerol + an acyl-CoA => a triacyl-sn-glycerol + CoA"}
{"X":41538,"RHEA_ID":39845,"compounds":"a triacyl-sn-glycerol + CoA => 1,3-diacyl-sn-glycerol + an acyl-CoA"}
{"X":41539,"RHEA_ID":39846,"compounds":"1,3-diacyl-sn-glycerol + an acyl-CoA <=> a triacyl-sn-glycerol + CoA"}
{"X":41540,"RHEA_ID":49816,"DIRECTION":"UN","MASTER_ID":49816,"ec":"1.7.2.7","compounds":"3 [Fe(III)cytochrome c] + H2O + hydrazine = 3 [Fe(II)cytochrome c] + 2 H(+) + NH4(+) + nitric oxide"}
{"X":41541,"RHEA_ID":39848,"compounds":"a 2-acylglycerol + ATP => a 2-acyl-sn-glycerol 3-phosphate + ADP + H(+)"}
{"X":41542,"RHEA_ID":39849,"compounds":"a 2-acyl-sn-glycerol 3-phosphate + ADP + H(+) => a 2-acylglycerol + ATP"}
{"X":41543,"RHEA_ID":39850,"compounds":"a 2-acylglycerol + ATP <=> a 2-acyl-sn-glycerol 3-phosphate + ADP + H(+)"}
{"X":41544,"RHEA_ID":49828,"compounds":"(5E)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,5E)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":41545,"RHEA_ID":39852,"compounds":"2 a 1-acyl-sn-glycerol => a 1,2-diacyl-sn-glycerol + glycerol"}
{"X":41546,"RHEA_ID":39853,"compounds":"a 1,2-diacyl-sn-glycerol + glycerol => 2 a 1-acyl-sn-glycerol"}
{"X":41547,"RHEA_ID":39854,"compounds":"2 a 1-acyl-sn-glycerol <=> a 1,2-diacyl-sn-glycerol + glycerol"}
{"X":41548,"RHEA_ID":39855,"compounds":"a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycerol = a triacyl-sn-glycerol + glycerol"}
{"X":41549,"RHEA_ID":39856,"compounds":"a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycerol => a triacyl-sn-glycerol + glycerol"}
{"X":41550,"RHEA_ID":39857,"compounds":"a triacyl-sn-glycerol + glycerol => a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycerol"}
{"X":41551,"RHEA_ID":39858,"compounds":"a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycerol <=> a triacyl-sn-glycerol + glycerol"}
{"X":41552,"RHEA_ID":49836,"compounds":"(5E)-tetradecenoyl-CoA + (R)-carnitine = (5E)-tetradecenoyl-(R)-carnitine + CoA"}
{"X":41553,"RHEA_ID":39860,"compounds":"1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycerol => a triacyl-sn-glycerol + glycerol"}
{"X":41554,"RHEA_ID":39861,"compounds":"a triacyl-sn-glycerol + glycerol => 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycerol"}
{"X":41555,"RHEA_ID":39862,"compounds":"1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycerol <=> a triacyl-sn-glycerol + glycerol"}
{"X":41556,"RHEA_ID":49840,"compounds":"(-)-dehydrodiconiferyl acid + 2 a quinone + H2O = (-)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+)"}
{"X":41557,"RHEA_ID":39864,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol => 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine"}
{"X":41558,"RHEA_ID":39865,"compounds":"1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol"}
{"X":41559,"RHEA_ID":39866,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol <=> 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine"}
{"X":41560,"RHEA_ID":49844,"compounds":"(-)-dehydrodiconiferyl acid + a quinone = (-)-dehydrodiconiferyl acid ketone + a quinol"}
{"X":41561,"RHEA_ID":39872,"compounds":"3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine => 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine"}
{"X":41562,"RHEA_ID":39873,"compounds":"1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine => 3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine"}
{"X":41563,"RHEA_ID":39874,"compounds":"3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine"}
{"X":41564,"RHEA_ID":49848,"compounds":"(-)-dehydrodiconiferyl acid ketone + a quinone + H2O = (-)-dehydrodiconiferyl acid carboxylate + a quinol + H(+)"}
{"X":41565,"RHEA_ID":39876,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol => a 1-acyl-sn-glycero-3-phosphocholine + a 2,3-diacyl-sn-glycerol"}
{"X":41566,"RHEA_ID":39877,"compounds":"a 1-acyl-sn-glycero-3-phosphocholine + a 2,3-diacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol"}
{"X":41567,"RHEA_ID":39878,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol <=> a 1-acyl-sn-glycero-3-phosphocholine + a 2,3-diacyl-sn-glycerol"}
{"X":41568,"RHEA_ID":49852,"compounds":"(3E)-octenoyl-CoA = (2E)-octenoyl-CoA"}
{"X":41569,"RHEA_ID":39880,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol => a 1-acyl-sn-glycero-3-phosphoethanolamine + a 2,3-diacyl-sn-glycerol"}
{"X":41570,"RHEA_ID":39881,"compounds":"a 1-acyl-sn-glycero-3-phosphoethanolamine + a 2,3-diacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol"}
{"X":41571,"RHEA_ID":39882,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol <=> a 1-acyl-sn-glycero-3-phosphoethanolamine + a 2,3-diacyl-sn-glycerol"}
{"X":41572,"RHEA_ID":49856,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41573,"RHEA_ID":39884,"compounds":"dTDP-6-deoxy-alpha-D-allose + NADP(+) => dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADPH"}
{"X":41574,"RHEA_ID":39885,"DIRECTION":"RL","MASTER_ID":39883,"metacyc":"RXN-15048","compounds":"dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADPH => dTDP-6-deoxy-alpha-D-allose + NADP(+)"}
{"X":41575,"RHEA_ID":49859,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41576,"RHEA_ID":49860,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41577,"RHEA_ID":39888,"DIRECTION":"LR","MASTER_ID":39887,"metacyc":"RXN-15099","compounds":"2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pikromycin"}
{"X":41578,"RHEA_ID":39889,"compounds":"H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pikromycin => 2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":41579,"RHEA_ID":49863,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41580,"RHEA_ID":49864,"compounds":"(+)-dehydrodiconiferyl acid + 2 a quinone + H2O = (+)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+)"}
{"X":41581,"RHEA_ID":39892,"DIRECTION":"LR","MASTER_ID":39891,"metacyc":"RXN-15235","compounds":"devancoaminyl-vancomycin + dTDP-beta-L-vancosamine => dTDP + H(+) + vancomycin"}
{"X":41582,"RHEA_ID":39893,"compounds":"dTDP + H(+) + vancomycin => devancoaminyl-vancomycin + dTDP-beta-L-vancosamine"}
{"X":41583,"RHEA_ID":49867,"DIRECTION":"BI","MASTER_ID":49864,"metacyc":"RXN-17553","compounds":"(+)-dehydrodiconiferyl acid + 2 a quinone + H2O <=> (+)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+)"}
{"X":41584,"RHEA_ID":39895,"DIRECTION":"UN","MASTER_ID":39895,"ec":"2.4.1.323","compounds":"7-deoxyloganetate + UDP-alpha-D-glucose = 7-deoxyloganate + H(+) + UDP"}
{"X":41585,"RHEA_ID":39896,"DIRECTION":"LR","MASTER_ID":39895,"metacyc":"RXN-9372","compounds":"7-deoxyloganetate + UDP-alpha-D-glucose => 7-deoxyloganate + H(+) + UDP"}
{"X":41586,"RHEA_ID":39897,"compounds":"7-deoxyloganate + H(+) + UDP => 7-deoxyloganetate + UDP-alpha-D-glucose"}
{"X":41587,"RHEA_ID":49871,"DIRECTION":"BI","MASTER_ID":49868,"metacyc":"RXN-17550","compounds":"(+)-dehydrodiconiferyl acid + a quinone <=> (+)-dehydrodiconiferyl acid ketone + a quinol"}
{"X":41588,"RHEA_ID":49872,"compounds":"(+)-dehydrodiconiferyl acid ketone + a quinone + H2O = (+)-dehydrodiconiferyl acid carboxylate + a quinol + H(+)"}
{"X":41589,"RHEA_ID":39900,"compounds":"7-deoxyloganetin + UDP-alpha-D-glucose => 7-deoxyloganin + H(+) + UDP"}
{"X":41590,"RHEA_ID":39901,"compounds":"7-deoxyloganin + H(+) + UDP => 7-deoxyloganetin + UDP-alpha-D-glucose"}
{"X":41591,"RHEA_ID":49875,"DIRECTION":"BI","MASTER_ID":49872,"metacyc":"RXN-17551","compounds":"(+)-dehydrodiconiferyl acid ketone + a quinone + H2O <=> (+)-dehydrodiconiferyl acid carboxylate + a quinol + H(+)"}
{"X":41592,"RHEA_ID":49876,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41593,"RHEA_ID":39904,"compounds":"isoxazolin-5-one + O-acetyl-L-serine => 3-(5-oxoisoxazolin-4-yl)-L-alanine + acetate + H(+)"}
{"X":41594,"RHEA_ID":39905,"compounds":"3-(5-oxoisoxazolin-4-yl)-L-alanine + acetate + H(+) => isoxazolin-5-one + O-acetyl-L-serine"}
{"X":41595,"RHEA_ID":49879,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41596,"RHEA_ID":49880,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41597,"RHEA_ID":39908,"compounds":"2-oxoglutarate + dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose => dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + L-glutamate"}
{"X":41598,"RHEA_ID":39909,"compounds":"dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + L-glutamate => 2-oxoglutarate + dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose"}
{"X":41599,"RHEA_ID":49883,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41600,"RHEA_ID":39911,"DIRECTION":"UN","MASTER_ID":39911,"ec":"2.6.1.107","compounds":"(2S,3S)-3-methylphenylalanine + 2-oxoglutarate = (3S)-2-oxo-3-phenylbutanoate + L-glutamate"}
{"X":41601,"RHEA_ID":39912,"compounds":"(2S,3S)-3-methylphenylalanine + 2-oxoglutarate => (3S)-2-oxo-3-phenylbutanoate + L-glutamate"}
{"X":41602,"RHEA_ID":39913,"compounds":"(3S)-2-oxo-3-phenylbutanoate + L-glutamate => (2S,3S)-3-methylphenylalanine + 2-oxoglutarate"}
{"X":41603,"RHEA_ID":39914,"compounds":"(2S,3S)-3-methylphenylalanine + 2-oxoglutarate <=> (3S)-2-oxo-3-phenylbutanoate + L-glutamate"}
{"X":41604,"RHEA_ID":49888,"DIRECTION":"UN","MASTER_ID":49888,"ec":"1.10.3.16","compounds":"(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + O2 = (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + H2O2"}
{"X":41605,"RHEA_ID":39916,"compounds":"1-O-alkyl-sn-glycero-3-phosphate + H2O => 1-O-alkyl-sn-glycerol + phosphate"}
{"X":41606,"RHEA_ID":39917,"compounds":"1-O-alkyl-sn-glycerol + phosphate => 1-O-alkyl-sn-glycero-3-phosphate + H2O"}
{"X":41607,"RHEA_ID":39918,"compounds":"1-O-alkyl-sn-glycero-3-phosphate + H2O <=> 1-O-alkyl-sn-glycerol + phosphate"}
{"X":41608,"RHEA_ID":49892,"DIRECTION":"UN","MASTER_ID":49892,"ec":"1.10.3.16","compounds":"(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + O2 = (5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate + H2O2"}
{"X":41609,"RHEA_ID":39920,"compounds":"1-O-(alk-1-enyl)-sn-glycero-3-phosphate + H2O => 1-O-(alk-1-enyl)-sn-glycerol + phosphate"}
{"X":41610,"RHEA_ID":39921,"compounds":"1-O-(alk-1-enyl)-sn-glycerol + phosphate => 1-O-(alk-1-enyl)-sn-glycero-3-phosphate + H2O"}
{"X":41611,"RHEA_ID":39922,"compounds":"1-O-(alk-1-enyl)-sn-glycero-3-phosphate + H2O <=> 1-O-(alk-1-enyl)-sn-glycerol + phosphate"}
{"X":41612,"RHEA_ID":39923,"compounds":"1-O-octadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-octadecyl-sn-glycerol + H(+) + phosphocholine"}
{"X":41613,"RHEA_ID":39924,"compounds":"1-O-octadecyl-sn-glycero-3-phosphocholine + H2O => 1-O-octadecyl-sn-glycerol + H(+) + phosphocholine"}
{"X":41614,"RHEA_ID":39925,"compounds":"1-O-octadecyl-sn-glycerol + H(+) + phosphocholine => 1-O-octadecyl-sn-glycero-3-phosphocholine + H2O"}
{"X":41615,"RHEA_ID":39926,"compounds":"1-O-octadecyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-octadecyl-sn-glycerol + H(+) + phosphocholine"}
{"X":41616,"RHEA_ID":49900,"compounds":"5,10-dihydrophenazine-1,6-dicarboxylate + O2 = H2O2 + phenazine-1,6-dicarboxylate"}
{"X":41617,"RHEA_ID":39928,"compounds":"1-O-alkyl-sn-glycero-3-phosphocholine + H2O => 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)"}
{"X":41618,"RHEA_ID":39929,"compounds":"1-O-alkyl-sn-glycero-3-phosphate + choline + H(+) => 1-O-alkyl-sn-glycero-3-phosphocholine + H2O"}
{"X":41619,"RHEA_ID":39930,"compounds":"1-O-alkyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)"}
{"X":41620,"RHEA_ID":49904,"compounds":"(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + H(+) + O2 = (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + CO2 + H2O2"}
{"X":41621,"RHEA_ID":39932,"compounds":"1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H(+)"}
{"X":41622,"RHEA_ID":39933,"compounds":"(9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H(+) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O"}
{"X":41623,"RHEA_ID":39934,"compounds":"1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H(+)"}
{"X":41624,"RHEA_ID":49908,"compounds":"(R)-carnitine(out) + O-acetyl-(R)-carnitine(in) = (R)-carnitine(in) + O-acetyl-(R)-carnitine(out)"}
{"X":41625,"RHEA_ID":39936,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O => (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)"}
{"X":41626,"RHEA_ID":39937,"compounds":"(9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O"}
{"X":41627,"RHEA_ID":39938,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O <=> (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)"}
{"X":41628,"RHEA_ID":39939,"compounds":"1,3-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)"}
{"X":41629,"RHEA_ID":39940,"compounds":"1,3-di-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)"}
{"X":41630,"RHEA_ID":39941,"compounds":"(9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+) => 1,3-di-(9Z-octadecenoyl)-glycerol + H2O"}
{"X":41631,"RHEA_ID":39942,"compounds":"1,3-di-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)"}
{"X":41632,"RHEA_ID":49916,"compounds":"(R)-carnitine(out) + O-hexadecanoyl-(R)-carnitine(in) = (R)-carnitine(in) + O-hexadecanoyl-(R)-carnitine(out)"}
{"X":41633,"RHEA_ID":39944,"compounds":"a 1-acylglycerol + an acyl-CoA => a 1,2-diacylglycerol + CoA"}
{"X":41634,"RHEA_ID":39945,"compounds":"a 1,2-diacylglycerol + CoA => a 1-acylglycerol + an acyl-CoA"}
{"X":41635,"RHEA_ID":39946,"compounds":"a 1-acylglycerol + an acyl-CoA <=> a 1,2-diacylglycerol + CoA"}
{"X":41636,"RHEA_ID":49920,"compounds":"(R)-carnitine(out) + O-octanoyl-(R)-carnitine(in) = (R)-carnitine(in) + O-octanoyl-(R)-carnitine(out)"}
{"X":41637,"RHEA_ID":39948,"compounds":"1,3-diacyl-sn-glycerol + H2O => a fatty acid + a monoacylglycerol + H(+)"}
{"X":41638,"RHEA_ID":39949,"compounds":"a fatty acid + a monoacylglycerol + H(+) => 1,3-diacyl-sn-glycerol + H2O"}
{"X":41639,"RHEA_ID":39950,"compounds":"1,3-diacyl-sn-glycerol + H2O <=> a fatty acid + a monoacylglycerol + H(+)"}
{"X":41640,"RHEA_ID":49924,"compounds":"(R)-carnitine(out) + O-acyl-(R)-carnitine(in) = (R)-carnitine(in) + O-acyl-(R)-carnitine(out)"}
{"X":41641,"RHEA_ID":39952,"compounds":"(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-glycerol + CoA"}
{"X":41642,"RHEA_ID":39953,"compounds":"1,2-di-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol"}
{"X":41643,"RHEA_ID":39954,"compounds":"(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol <=> 1,2-di-(9Z-octadecenoyl)-glycerol + CoA"}
{"X":41644,"RHEA_ID":49928,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41645,"RHEA_ID":39956,"compounds":"(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + glycerol + H(+)"}
{"X":41646,"RHEA_ID":39957,"compounds":"(9Z)-octadecenoate + glycerol + H(+) => (9Z-octadecenoyl)-glycerol + H2O"}
{"X":41647,"RHEA_ID":39958,"compounds":"(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + glycerol + H(+)"}
{"X":41648,"RHEA_ID":49932,"compounds":"(3E,5Z)-octadienoyl-CoA = (2E,5Z)-octadienoyl-CoA"}
{"X":41649,"RHEA_ID":39960,"compounds":"1-hexadecanoylglycerol + H2O => glycerol + H(+) + hexadecanoate"}
{"X":41650,"RHEA_ID":39961,"compounds":"glycerol + H(+) + hexadecanoate => 1-hexadecanoylglycerol + H2O"}
{"X":41651,"RHEA_ID":39962,"compounds":"1-hexadecanoylglycerol + H2O <=> glycerol + H(+) + hexadecanoate"}
{"X":41652,"RHEA_ID":49936,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41653,"RHEA_ID":39964,"compounds":"2-hexadecanoylglycerol + H2O => glycerol + H(+) + hexadecanoate"}
{"X":41654,"RHEA_ID":39965,"compounds":"glycerol + H(+) + hexadecanoate => 2-hexadecanoylglycerol + H2O"}
{"X":41655,"RHEA_ID":46558,"compounds":"2 [Fe(III)-cytochrome b5] + cholesta-5,7-dien-3beta-ol + 2 H2O => 5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}
{"X":41656,"RHEA_ID":49940,"DIRECTION":"UN","MASTER_ID":49940,"ec":"1.10.3.16","compounds":"(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + O2 = (10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2"}
{"X":41657,"RHEA_ID":39968,"DIRECTION":"LR","MASTER_ID":39967,"ecocyc":"RXN-15121","metacyc":"RXN-15121","compounds":"2-aminobut-2-enoate => 2-iminobutanoate"}
{"X":41658,"RHEA_ID":39969,"compounds":"2-iminobutanoate => 2-aminobut-2-enoate"}
{"X":41659,"RHEA_ID":53249,"compounds":"cholesta-5,7-dien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => 3beta-hydroxycholest-5-en-7-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41660,"RHEA_ID":39971,"compounds":"1-aminocyclopropane-1-carboxylate = 2-aminobut-2-enoate"}
{"X":41661,"RHEA_ID":39972,"DIRECTION":"LR","MASTER_ID":39971,"metacyc":"RXN-15149","compounds":"1-aminocyclopropane-1-carboxylate => 2-aminobut-2-enoate"}
{"X":41662,"RHEA_ID":49946,"compounds":"(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate => (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate"}
{"X":41663,"RHEA_ID":39974,"compounds":"1-aminocyclopropane-1-carboxylate <=> 2-aminobut-2-enoate"}
{"X":41664,"RHEA_ID":39975,"DIRECTION":"UN","MASTER_ID":39975,"ec":"3.5.99.10","compounds":"2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)"}
{"X":41665,"RHEA_ID":39976,"DIRECTION":"LR","MASTER_ID":39975,"ecocyc":"RXN-15123","metacyc":"RXN-15123","compounds":"2-iminobutanoate + H2O => 2-oxobutanoate + NH4(+)"}
{"X":41666,"RHEA_ID":49950,"compounds":"(10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2 => (1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + O2"}
{"X":41667,"RHEA_ID":49951,"compounds":"(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + O2 <=> (10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2"}
{"X":41668,"RHEA_ID":39979,"DIRECTION":"UN","MASTER_ID":39979,"ec":"2.1.1.300","compounds":"(+-)-pavine + S-adenosyl-L-methionine = H(+) + N-methylpavine + S-adenosyl-L-homocysteine"}
{"X":41669,"RHEA_ID":39980,"DIRECTION":"LR","MASTER_ID":39979,"metacyc":"RXN-15244","compounds":"(+-)-pavine + S-adenosyl-L-methionine => H(+) + N-methylpavine + S-adenosyl-L-homocysteine"}
{"X":41670,"RHEA_ID":39981,"compounds":"H(+) + N-methylpavine + S-adenosyl-L-homocysteine => (+-)-pavine + S-adenosyl-L-methionine"}
{"X":41671,"RHEA_ID":60005,"compounds":"(L-glutamyl)n+1-L-gamma-glutamyl-L-glutamyl-[protein] + H2O => (L-glutamyl)n-L-gamma-glutamyl-L-glutamyl-[protein] + L-glutamate"}
{"X":41672,"RHEA_ID":39983,"compounds":"2 [Fe(II)-cytochrome b5] + a 1,2-saturated fatty acid + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a 2-hydroxy fatty acid + H2O"}
{"X":41673,"RHEA_ID":39984,"compounds":"2 [Fe(II)-cytochrome b5] + a 1,2-saturated fatty acid + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a 2-hydroxy fatty acid + H2O"}
{"X":41674,"RHEA_ID":39985,"compounds":"2 [Fe(III)-cytochrome b5] + a 2-hydroxy fatty acid + H2O => 2 [Fe(II)-cytochrome b5] + a 1,2-saturated fatty acid + 2 H(+) + O2"}
{"X":41675,"RHEA_ID":53265,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 2beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41676,"RHEA_ID":39987,"compounds":"1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol = all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol"}
{"X":41677,"RHEA_ID":39988,"compounds":"1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol => all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol"}
{"X":41678,"RHEA_ID":39989,"compounds":"all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol"}
{"X":41679,"RHEA_ID":39990,"compounds":"1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol <=> all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol"}
{"X":41680,"RHEA_ID":39991,"compounds":"(4R)-hydroxyeicosasphinganine + an acyl-CoA = CoA + H(+) + N-acyl-4-hydroxyeicosasphinganine"}
{"X":41681,"RHEA_ID":39992,"compounds":"(4R)-hydroxyeicosasphinganine + an acyl-CoA => CoA + H(+) + N-acyl-4-hydroxyeicosasphinganine"}
{"X":41682,"RHEA_ID":49966,"compounds":"H2O2 + phenazine => 5,10-dihydrophenazine + O2"}
{"X":41683,"RHEA_ID":39994,"compounds":"(4R)-hydroxyeicosasphinganine + an acyl-CoA <=> CoA + H(+) + N-acyl-4-hydroxyeicosasphinganine"}
{"X":41684,"RHEA_ID":39995,"compounds":"an N-acylethanolamine + H2O = a fatty acid + ethanolamine"}
{"X":41685,"RHEA_ID":39996,"compounds":"an N-acylethanolamine + H2O => a fatty acid + ethanolamine"}
{"X":41686,"RHEA_ID":39997,"compounds":"a fatty acid + ethanolamine => an N-acylethanolamine + H2O"}
{"X":41687,"RHEA_ID":39998,"compounds":"an N-acylethanolamine + H2O <=> a fatty acid + ethanolamine"}
{"X":41688,"RHEA_ID":49972,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41689,"RHEA_ID":40000,"compounds":"a sphingoid 1-phosphate => a fatty aldehyde + phosphoethanolamine"}
{"X":41690,"RHEA_ID":40001,"compounds":"a fatty aldehyde + phosphoethanolamine => a sphingoid 1-phosphate"}
{"X":41691,"RHEA_ID":40002,"compounds":"a sphingoid 1-phosphate <=> a fatty aldehyde + phosphoethanolamine"}
{"X":41692,"RHEA_ID":49976,"compounds":"butanoyl-CoA + H2O = adenosine 3',5'-bisphosphate + butanoyl-4'-phosphopantetheine + 2 H(+)"}
{"X":41693,"RHEA_ID":40004,"compounds":"ent-copalyl diphosphate => (Z)-biformene + diphosphate"}
{"X":41694,"RHEA_ID":40005,"compounds":"(Z)-biformene + diphosphate => ent-copalyl diphosphate"}
{"X":41695,"RHEA_ID":40006,"DIRECTION":"BI","MASTER_ID":40003,"metacyc":"RXN-12985","compounds":"ent-copalyl diphosphate <=> (Z)-biformene + diphosphate"}
{"X":41696,"RHEA_ID":49980,"compounds":"H2O + hexanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + hexanoyl-4'-phosphopantetheine"}
{"X":41697,"RHEA_ID":40008,"compounds":"(+)-copalyl diphosphate + H2O => (+)-copalol + diphosphate"}
{"X":41698,"RHEA_ID":40009,"compounds":"(+)-copalol + diphosphate => (+)-copalyl diphosphate + H2O"}
{"X":41699,"RHEA_ID":40010,"DIRECTION":"BI","MASTER_ID":40007,"metacyc":"RXN-12986","compounds":"(+)-copalyl diphosphate + H2O <=> (+)-copalol + diphosphate"}
{"X":41700,"RHEA_ID":49984,"DIRECTION":"UN","MASTER_ID":49984,"ec":"1.14.13.228","compounds":"H(+) + jasmonate + NADPH + O2 = (1R,2R)-12-hydroxyjasmonate + H2O + NADP(+)"}
{"X":41701,"RHEA_ID":40012,"compounds":"(+)-copalyl diphosphate + H2O => diphosphate + manool"}
{"X":41702,"RHEA_ID":40013,"compounds":"diphosphate + manool => (+)-copalyl diphosphate + H2O"}
{"X":41703,"RHEA_ID":40014,"DIRECTION":"BI","MASTER_ID":40011,"metacyc":"RXN-12987","compounds":"(+)-copalyl diphosphate + H2O <=> diphosphate + manool"}
{"X":41704,"RHEA_ID":60038,"compounds":"3-hydroxy-3-methylhexanoate + L-glutamine => H2O + N(2)-(3-hydroxy-3-methylhexanoyl)-L-glutaminate"}
{"X":41705,"RHEA_ID":40016,"compounds":"(+)-copalyl diphosphate + H2O => 13-epi-manool + diphosphate"}
{"X":41706,"RHEA_ID":40017,"compounds":"13-epi-manool + diphosphate => (+)-copalyl diphosphate + H2O"}
{"X":41707,"RHEA_ID":40018,"DIRECTION":"BI","MASTER_ID":40015,"metacyc":"RXN-12988","compounds":"(+)-copalyl diphosphate + H2O <=> 13-epi-manool + diphosphate"}
{"X":41708,"RHEA_ID":49992,"DIRECTION":"UN","MASTER_ID":49992,"ec":"1.14.13.227","compounds":"H(+) + NADH + O2 + propane = H2O + NAD(+) + propan-2-ol"}
{"X":41709,"RHEA_ID":40020,"compounds":"ent-copalyl diphosphate + H2O => (-)-ent-copalol + diphosphate"}
{"X":41710,"RHEA_ID":40021,"compounds":"(-)-ent-copalol + diphosphate => ent-copalyl diphosphate + H2O"}
{"X":41711,"RHEA_ID":40022,"DIRECTION":"BI","MASTER_ID":40019,"metacyc":"RXN-12995","compounds":"ent-copalyl diphosphate + H2O <=> (-)-ent-copalol + diphosphate"}
{"X":41712,"RHEA_ID":49996,"DIRECTION":"UN","MASTER_ID":49996,"ec":"1.14.15.28","compounds":"cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] = (25R)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":41713,"RHEA_ID":40024,"compounds":"9alpha-copalyl diphosphate + H2O => diphosphate + syn-copalol"}
{"X":41714,"RHEA_ID":40025,"compounds":"diphosphate + syn-copalol => 9alpha-copalyl diphosphate + H2O"}
{"X":41715,"RHEA_ID":40026,"DIRECTION":"BI","MASTER_ID":40023,"metacyc":"RXN-12999","compounds":"9alpha-copalyl diphosphate + H2O <=> diphosphate + syn-copalol"}
{"X":41716,"RHEA_ID":50000,"DIRECTION":"UN","MASTER_ID":50000,"ec":"1.14.13.230","compounds":"butane + H(+) + NADH + O2 = butan-1-ol + H2O + NAD(+)"}
{"X":41717,"RHEA_ID":40028,"DIRECTION":"LR","MASTER_ID":40027,"metacyc":"RXN-13000","compounds":"9alpha-copalyl diphosphate + H2O => (13S)-vitexifolin A + diphosphate"}
{"X":41718,"RHEA_ID":40029,"compounds":"(13S)-vitexifolin A + diphosphate => 9alpha-copalyl diphosphate + H2O"}
{"X":41719,"RHEA_ID":40030,"compounds":"9alpha-copalyl diphosphate + H2O <=> (13S)-vitexifolin A + diphosphate"}
{"X":41720,"RHEA_ID":50004,"DIRECTION":"UN","MASTER_ID":50004,"ec":"1.14.13.231","compounds":"H(+) + NADPH + O2 + tetracycline = 11a-hydroxytetracycline + H2O + NADP(+)"}
{"X":41721,"RHEA_ID":40032,"compounds":"ent-copalyl diphosphate + H2O => diphosphate + ent-manool"}
{"X":41722,"RHEA_ID":40033,"compounds":"diphosphate + ent-manool => ent-copalyl diphosphate + H2O"}
{"X":41723,"RHEA_ID":40034,"DIRECTION":"BI","MASTER_ID":40031,"metacyc":"RXN-12996","compounds":"ent-copalyl diphosphate + H2O <=> diphosphate + ent-manool"}
{"X":41724,"RHEA_ID":53314,"compounds":"16(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":41725,"RHEA_ID":40036,"DIRECTION":"LR","MASTER_ID":40035,"metacyc":"RXN-15265","compounds":"ATP + L-glutamate + N-acetyl-L-aspartate => ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate + phosphate"}
{"X":41726,"RHEA_ID":40037,"compounds":"ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate + phosphate => ATP + L-glutamate + N-acetyl-L-aspartate"}
{"X":41727,"RHEA_ID":60061,"compounds":"a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose => alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP"}
{"X":41728,"RHEA_ID":50012,"DIRECTION":"UN","MASTER_ID":50012,"ec":"1.14.13.229","compounds":"H(+) + NADPH + O2 + tert-butanol = 2-methylpropane-1,2-diol + H2O + NADP(+)"}
{"X":41729,"RHEA_ID":40040,"DIRECTION":"LR","MASTER_ID":40039,"metacyc":"RXN-15267","compounds":"2 ATP + 2 L-glutamate + N-acetyl-L-aspartate => 2 ADP + 2 H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate + 2 phosphate"}
{"X":41730,"RHEA_ID":40041,"compounds":"2 ADP + 2 H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate + 2 phosphate => 2 ATP + 2 L-glutamate + N-acetyl-L-aspartate"}
{"X":41731,"RHEA_ID":50016,"compounds":"H2O + octanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + octanoyl-4'-phosphopantetheine"}
{"X":41732,"RHEA_ID":40044,"DIRECTION":"LR","MASTER_ID":40043,"metacyc":"RXN-15266","compounds":"ATP + citrate + L-glutamate => ADP + beta-citrylglutamate + H(+) + phosphate"}
{"X":41733,"RHEA_ID":40045,"compounds":"ADP + beta-citrylglutamate + H(+) + phosphate => ATP + citrate + L-glutamate"}
{"X":41734,"RHEA_ID":50019,"compounds":"H2O + octanoyl-CoA <=> adenosine 3',5'-bisphosphate + 2 H(+) + octanoyl-4'-phosphopantetheine"}
{"X":41735,"RHEA_ID":50020,"compounds":"decanoyl-CoA + H2O = adenosine 3',5'-bisphosphate + decanoyl-4'-phosphopantetheine + 2 H(+)"}
{"X":41736,"RHEA_ID":50021,"compounds":"decanoyl-CoA + H2O => adenosine 3',5'-bisphosphate + decanoyl-4'-phosphopantetheine + 2 H(+)"}
{"X":41737,"RHEA_ID":40049,"compounds":"1,2-dioctanoyl-sn-glycerol + H(+) + octanoate => 1,2,3-trioctanoylglycerol + H2O"}
{"X":41738,"RHEA_ID":40050,"compounds":"1,2,3-trioctanoylglycerol + H2O <=> 1,2-dioctanoyl-sn-glycerol + H(+) + octanoate"}
{"X":41739,"RHEA_ID":50024,"compounds":"dodecanoyl-CoA + H2O = adenosine 3',5'-bisphosphate + dodecanoyl-4'-phosphopantetheine + 2 H(+)"}
{"X":41740,"RHEA_ID":50025,"compounds":"dodecanoyl-CoA + H2O => adenosine 3',5'-bisphosphate + dodecanoyl-4'-phosphopantetheine + 2 H(+)"}
{"X":41741,"RHEA_ID":40053,"compounds":"3-[(1-carboxyvinyl)-oxy]benzoate + H2O => chorismate"}
{"X":41742,"RHEA_ID":50027,"compounds":"dodecanoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + dodecanoyl-4'-phosphopantetheine + 2 H(+)"}
{"X":41743,"RHEA_ID":50028,"compounds":"H2O + tetradecanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + tetradecanoyl-4'-phosphopantetheine"}
{"X":41744,"RHEA_ID":50029,"compounds":"H2O + tetradecanoyl-CoA => adenosine 3',5'-bisphosphate + 2 H(+) + tetradecanoyl-4'-phosphopantetheine"}
{"X":41745,"RHEA_ID":40057,"compounds":"2,3-dioctanoyl-sn-glycerol + H(+) + octanoate => 1,2,3-trioctanoylglycerol + H2O"}
{"X":41746,"RHEA_ID":40058,"compounds":"1,2,3-trioctanoylglycerol + H2O <=> 2,3-dioctanoyl-sn-glycerol + H(+) + octanoate"}
{"X":41747,"RHEA_ID":40059,"compounds":"decanoyl-CoA + H2O = CoA + decanoate + H(+)"}
{"X":41748,"RHEA_ID":50033,"compounds":"H2O + hexadecanoyl-CoA => adenosine 3',5'-bisphosphate + 2 H(+) + hexadecanoyl-4'-phosphopantetheine"}
{"X":41749,"RHEA_ID":40061,"compounds":"CoA + decanoate + H(+) => decanoyl-CoA + H2O"}
{"X":41750,"RHEA_ID":40062,"compounds":"decanoyl-CoA + H2O <=> CoA + decanoate + H(+)"}
{"X":41751,"RHEA_ID":40063,"compounds":"6-oxocyclohex-1-ene-1-carbonyl-CoA + H2O = 2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA"}
{"X":41752,"RHEA_ID":50037,"compounds":"choloyl-CoA + H2O => adenosine 3',5'-bisphosphate + choloyl-4'-phosphopantetheine + 2 H(+)"}
{"X":41753,"RHEA_ID":40065,"compounds":"2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA => 6-oxocyclohex-1-ene-1-carbonyl-CoA + H2O"}
{"X":41754,"RHEA_ID":50039,"compounds":"choloyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + choloyl-4'-phosphopantetheine + 2 H(+)"}
{"X":41755,"RHEA_ID":40067,"compounds":"2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA + H2O = 3-hydroxy-6-carboxyhexanoyl-CoA + H(+)"}
{"X":41756,"RHEA_ID":50041,"compounds":"3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)"}
{"X":41757,"RHEA_ID":40069,"compounds":"3-hydroxy-6-carboxyhexanoyl-CoA + H(+) => 2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA + H2O"}
{"X":41758,"RHEA_ID":50043,"compounds":"3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O <=> 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)"}
{"X":41759,"RHEA_ID":40071,"compounds":"2-aminoprop-2-enoate + H2O = NH4(+) + pyruvate"}
{"X":41760,"RHEA_ID":50045,"compounds":"an acyl-CoA + H2O => acyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)"}
{"X":41761,"RHEA_ID":40073,"compounds":"NH4(+) + pyruvate => 2-aminoprop-2-enoate + H2O"}
{"X":41762,"RHEA_ID":40074,"compounds":"2-aminoprop-2-enoate + H2O <=> NH4(+) + pyruvate"}
{"X":41763,"RHEA_ID":40075,"DIRECTION":"UN","MASTER_ID":40075,"ec":"3.5.4.40","compounds":"6-amino-6-deoxyfutalosine + H(+) + H2O = futalosine + NH4(+)"}
{"X":41764,"RHEA_ID":50049,"compounds":"ATP + cholate(in) + H2O => ADP + cholate(out) + H(+) + phosphate"}
{"X":41765,"RHEA_ID":40077,"compounds":"futalosine + NH4(+) => 6-amino-6-deoxyfutalosine + H(+) + H2O"}
{"X":41766,"RHEA_ID":50051,"compounds":"ATP + cholate(in) + H2O <=> ADP + cholate(out) + H(+) + phosphate"}
{"X":41767,"RHEA_ID":40079,"compounds":"docosanoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-hydroxydocosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41768,"RHEA_ID":50053,"compounds":"ATP + H2O + taurocholate(in) => ADP + H(+) + phosphate + taurocholate(out)"}
{"X":41769,"RHEA_ID":40081,"compounds":"22-hydroxydocosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => docosanoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":41770,"RHEA_ID":40082,"compounds":"docosanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 22-hydroxydocosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41771,"RHEA_ID":40083,"compounds":"hexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] = 26-hydroxyhexacosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41772,"RHEA_ID":50057,"compounds":"ATP + glycocholate(in) + H2O => ADP + glycocholate(out) + H(+) + phosphate"}
{"X":41773,"RHEA_ID":40085,"compounds":"26-hydroxyhexacosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => hexacosanoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":41774,"RHEA_ID":40086,"compounds":"hexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 26-hydroxyhexacosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41775,"RHEA_ID":40087,"compounds":"22-hydroxydocosanoate + NAD(+) = 22-oxodocosanoate + H(+) + NADH"}
{"X":41776,"RHEA_ID":50061,"compounds":"ATP + glycochenodeoxycholate(in) + H2O => ADP + glycochenodeoxycholate(out) + H(+) + phosphate"}
{"X":41777,"RHEA_ID":40089,"compounds":"22-oxodocosanoate + H(+) + NADH => 22-hydroxydocosanoate + NAD(+)"}
{"X":41778,"RHEA_ID":40090,"compounds":"22-hydroxydocosanoate + NAD(+) <=> 22-oxodocosanoate + H(+) + NADH"}
{"X":41779,"RHEA_ID":40091,"compounds":"26-hydroxyhexacosanoate + NAD(+) = 26-oxohexacosanoate + H(+) + NADH"}
{"X":41780,"RHEA_ID":50065,"compounds":"ATP + H2O + taurochenodeoxycholate(in) => ADP + H(+) + phosphate + taurochenodeoxycholate(out)"}
{"X":41781,"RHEA_ID":40093,"compounds":"26-oxohexacosanoate + H(+) + NADH => 26-hydroxyhexacosanoate + NAD(+)"}
{"X":41782,"RHEA_ID":40094,"compounds":"26-hydroxyhexacosanoate + NAD(+) <=> 26-oxohexacosanoate + H(+) + NADH"}
{"X":41783,"RHEA_ID":40095,"compounds":"26-oxohexacosanoate + H2O + NAD(+) = 2 H(+) + hexacosanedioate + NADH"}
{"X":41784,"RHEA_ID":50069,"compounds":"ATP + glycoursodeoxycholate(in) + H2O => ADP + glycoursodeoxycholate(out) + H(+) + phosphate"}
{"X":41785,"RHEA_ID":40097,"compounds":"2 H(+) + hexacosanedioate + NADH => 26-oxohexacosanoate + H2O + NAD(+)"}
{"X":41786,"RHEA_ID":40098,"compounds":"26-oxohexacosanoate + H2O + NAD(+) <=> 2 H(+) + hexacosanedioate + NADH"}
{"X":41787,"RHEA_ID":40099,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA = 1-(9Z-octadecenoyl)-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":41788,"RHEA_ID":50073,"compounds":"ATP + H2O + tauroursodeoxycholate(in) => ADP + H(+) + phosphate + tauroursodeoxycholate(out)"}
{"X":41789,"RHEA_ID":40101,"compounds":"1-(9Z-octadecenoyl)-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA"}
{"X":41790,"RHEA_ID":40102,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA <=> 1-(9Z-octadecenoyl)-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":41791,"RHEA_ID":40103,"compounds":"H2O + propanoyl-CoA = CoA + H(+) + propanoate"}
{"X":41792,"RHEA_ID":50077,"compounds":"(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41793,"RHEA_ID":40105,"compounds":"CoA + H(+) + propanoate => H2O + propanoyl-CoA"}
{"X":41794,"RHEA_ID":40106,"compounds":"H2O + propanoyl-CoA <=> CoA + H(+) + propanoate"}
{"X":41795,"RHEA_ID":40107,"compounds":"1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":41796,"RHEA_ID":50081,"compounds":"ATP + H2O + taurodeoxycholate(in) => ADP + H(+) + phosphate + taurodeoxycholate(out)"}
{"X":41797,"RHEA_ID":40109,"compounds":"1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA"}
{"X":41798,"RHEA_ID":40110,"compounds":"1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA <=> 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA"}
{"X":41799,"RHEA_ID":40111,"compounds":"butanoyl-CoA + H2O = butanoate + CoA + H(+)"}
{"X":41800,"RHEA_ID":50085,"compounds":"ATP + H2O + taurolithocholate sulfate(in) => ADP + H(+) + phosphate + taurolithocholate sulfate(out)"}
{"X":41801,"RHEA_ID":40113,"compounds":"butanoate + CoA + H(+) => butanoyl-CoA + H2O"}
{"X":41802,"RHEA_ID":40114,"compounds":"butanoyl-CoA + H2O <=> butanoate + CoA + H(+)"}
{"X":41803,"RHEA_ID":40115,"compounds":"H2O + hexanoyl-CoA = CoA + H(+) + hexanoate"}
{"X":41804,"RHEA_ID":50089,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41805,"RHEA_ID":40117,"compounds":"CoA + H(+) + hexanoate => H2O + hexanoyl-CoA"}
{"X":41806,"RHEA_ID":40118,"compounds":"H2O + hexanoyl-CoA <=> CoA + H(+) + hexanoate"}
{"X":41807,"RHEA_ID":40119,"compounds":"H2O + tetradecanoyl-CoA = CoA + H(+) + tetradecanoate"}
{"X":41808,"RHEA_ID":40120,"DIRECTION":"LR","MASTER_ID":40119,"metacyc":"RXN-9626","compounds":"H2O + tetradecanoyl-CoA => CoA + H(+) + tetradecanoate"}
{"X":41809,"RHEA_ID":40121,"compounds":"CoA + H(+) + tetradecanoate => H2O + tetradecanoyl-CoA"}
{"X":41810,"RHEA_ID":40122,"compounds":"H2O + tetradecanoyl-CoA <=> CoA + H(+) + tetradecanoate"}
{"X":41811,"RHEA_ID":40123,"compounds":"an omega-hydroxy fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-oxo fatty acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41812,"RHEA_ID":50097,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate => 13-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41813,"RHEA_ID":40125,"compounds":"an omega-oxo fatty acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => an omega-hydroxy fatty acid + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":41814,"RHEA_ID":40126,"compounds":"an omega-hydroxy fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an omega-oxo fatty acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41815,"RHEA_ID":40127,"compounds":"an omega-oxo fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = a dicarboxylate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41816,"RHEA_ID":60150,"compounds":"(L-glutamyl)n+1-L-gamma-glutamyl-L-glutamyl-[protein] + ADP + H(+) + phosphate => (L-glutamyl)n-L-gamma-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate"}
{"X":41817,"RHEA_ID":40129,"compounds":"a dicarboxylate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an omega-oxo fatty acid + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":41818,"RHEA_ID":40130,"compounds":"an omega-oxo fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> a dicarboxylate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41819,"RHEA_ID":40131,"compounds":"(9Z)-hexadecenoyl-CoA + H2O = (9Z)-hexadecenoate + CoA + H(+)"}
{"X":41820,"RHEA_ID":50105,"compounds":"taurine + tetradecanoyl-CoA => CoA + H(+) + N-tetradecanoyl-taurine"}
{"X":41821,"RHEA_ID":40133,"compounds":"(9Z)-hexadecenoate + CoA + H(+) => (9Z)-hexadecenoyl-CoA + H2O"}
{"X":41822,"RHEA_ID":40134,"compounds":"(9Z)-hexadecenoyl-CoA + H2O <=> (9Z)-hexadecenoate + CoA + H(+)"}
{"X":41823,"RHEA_ID":40135,"compounds":"(9Z)-tetradecenoyl-CoA + H2O = (9Z)-tetradecenoate + CoA + H(+)"}
{"X":41824,"RHEA_ID":40136,"compounds":"(9Z)-tetradecenoyl-CoA + H2O => (9Z)-tetradecenoate + CoA + H(+)"}
{"X":41825,"RHEA_ID":40137,"compounds":"(9Z)-tetradecenoate + CoA + H(+) => (9Z)-tetradecenoyl-CoA + H2O"}
{"X":41826,"RHEA_ID":40138,"compounds":"(9Z)-tetradecenoyl-CoA + H2O <=> (9Z)-tetradecenoate + CoA + H(+)"}
{"X":41827,"RHEA_ID":40139,"compounds":"(9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+)"}
{"X":41828,"RHEA_ID":40140,"DIRECTION":"LR","MASTER_ID":40139,"metacyc":"RXN-9666","compounds":"(9Z)-octadecenoyl-CoA + H2O => (9Z)-octadecenoate + CoA + H(+)"}
{"X":41829,"RHEA_ID":40141,"compounds":"(9Z)-octadecenoate + CoA + H(+) => (9Z)-octadecenoyl-CoA + H2O"}
{"X":41830,"RHEA_ID":40142,"compounds":"(9Z)-octadecenoyl-CoA + H2O <=> (9Z)-octadecenoate + CoA + H(+)"}
{"X":41831,"RHEA_ID":40143,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + H2O = (9Z,12Z)-octadecadienoate + CoA + H(+)"}
{"X":41832,"RHEA_ID":50117,"compounds":"eicosanoyl-CoA + taurine => CoA + H(+) + N-eicosanoyl-taurine"}
{"X":41833,"RHEA_ID":50118,"compounds":"CoA + H(+) + N-eicosanoyl-taurine => eicosanoyl-CoA + taurine"}
{"X":41834,"RHEA_ID":40146,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + H2O <=> (9Z,12Z)-octadecadienoate + CoA + H(+)"}
{"X":41835,"RHEA_ID":40147,"compounds":"eicosanoyl-CoA + H2O = CoA + eicosanoate + H(+)"}
{"X":41836,"RHEA_ID":40148,"DIRECTION":"LR","MASTER_ID":40147,"metacyc":"RXN-9629","compounds":"eicosanoyl-CoA + H2O => CoA + eicosanoate + H(+)"}
{"X":41837,"RHEA_ID":50122,"compounds":"CoA + H(+) + N-tetracosanoyl-taurine => taurine + tetracosanoyl-CoA"}
{"X":41838,"RHEA_ID":40150,"compounds":"eicosanoyl-CoA + H2O <=> CoA + eicosanoate + H(+)"}
{"X":41839,"RHEA_ID":40151,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)"}
{"X":41840,"RHEA_ID":40152,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)"}
{"X":41841,"RHEA_ID":50126,"compounds":"8-oxoresolvin D1 + H(+) + NADH => NAD(+) + resolvin D1"}
{"X":41842,"RHEA_ID":40154,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)"}
{"X":41843,"RHEA_ID":40155,"DIRECTION":"UN","MASTER_ID":40155,"ec":"1.14.14.79","compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41844,"RHEA_ID":40156,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41845,"RHEA_ID":50130,"compounds":"17-oxoresolvin D1 + H(+) + NADH => NAD(+) + resolvin D1"}
{"X":41846,"RHEA_ID":50131,"compounds":"NAD(+) + resolvin D1 <=> 17-oxoresolvin D1 + H(+) + NADH"}
{"X":41847,"RHEA_ID":40159,"DIRECTION":"UN","MASTER_ID":40159,"ec":"1.1.1.367","compounds":"H(+) + NADH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose = NAD(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose"}
{"X":41848,"RHEA_ID":40160,"compounds":"H(+) + NADH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose => NAD(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose"}
{"X":41849,"RHEA_ID":40161,"compounds":"NAD(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose => H(+) + NADH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose"}
{"X":41850,"RHEA_ID":40162,"DIRECTION":"BI","MASTER_ID":40159,"metacyc":"RXN-14994","compounds":"H(+) + NADH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose <=> NAD(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose"}
{"X":41851,"RHEA_ID":40163,"DIRECTION":"UN","MASTER_ID":40163,"ec":"1.2.1.89","compounds":"D-glyceraldehyde + H2O + NADP(+) = (R)-glycerate + 2 H(+) + NADPH"}
{"X":41852,"RHEA_ID":50137,"compounds":"ethyl (9Z)-octadecenoate + H2O => (9Z)-octadecenoate + ethanol + H(+)"}
{"X":41853,"RHEA_ID":50138,"compounds":"(9Z)-octadecenoate + ethanol + H(+) => ethyl (9Z)-octadecenoate + H2O"}
{"X":41854,"RHEA_ID":50139,"compounds":"ethyl (9Z)-octadecenoate + H2O <=> (9Z)-octadecenoate + ethanol + H(+)"}
{"X":41855,"RHEA_ID":40167,"compounds":"hexadecanoyl-CoA + O2 = (2E)-hexadecenoyl-CoA + H2O2"}
{"X":41856,"RHEA_ID":40168,"compounds":"hexadecanoyl-CoA + O2 => (2E)-hexadecenoyl-CoA + H2O2"}
{"X":41857,"RHEA_ID":50142,"compounds":"(14S,15S)-epoxy-(5Z,8Z,10E,12E)-eicosatetraenoate + H2O => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate"}
{"X":41858,"RHEA_ID":40170,"compounds":"hexadecanoyl-CoA + O2 <=> (2E)-hexadecenoyl-CoA + H2O2"}
{"X":41859,"RHEA_ID":40171,"compounds":"dodecanoyl-CoA + O2 = (2E)-dodecenoyl-CoA + H2O2"}
{"X":41860,"RHEA_ID":53451,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate"}
{"X":41861,"RHEA_ID":50146,"compounds":"(9Z)-hexadecenoate + ethanol + H(+) => ethyl (9Z)-hexadecenoate + H2O"}
{"X":41862,"RHEA_ID":40174,"compounds":"dodecanoyl-CoA + O2 <=> (2E)-dodecenoyl-CoA + H2O2"}
{"X":41863,"RHEA_ID":40175,"compounds":"O2 + octanoyl-CoA = (2E)-octenoyl-CoA + H2O2"}
{"X":41864,"RHEA_ID":50149,"compounds":"a fatty acid ethyl ester + H2O => a fatty acid + ethanol + H(+)"}
{"X":41865,"RHEA_ID":50150,"compounds":"a fatty acid + ethanol + H(+) => a fatty acid ethyl ester + H2O"}
{"X":41866,"RHEA_ID":40178,"compounds":"O2 + octanoyl-CoA <=> (2E)-octenoyl-CoA + H2O2"}
{"X":41867,"RHEA_ID":40179,"compounds":"decanoyl-CoA + O2 = (2E)-decenoyl-CoA + H2O2"}
{"X":41868,"RHEA_ID":43467,"compounds":"H(+) + hexanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":41869,"RHEA_ID":50154,"compounds":"15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O => (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate"}
{"X":41870,"RHEA_ID":40182,"compounds":"decanoyl-CoA + O2 <=> (2E)-decenoyl-CoA + H2O2"}
{"X":41871,"RHEA_ID":40183,"compounds":"O2 + tetradecanoyl-CoA = (2E)-tetradecenoyl-CoA + H2O2"}
{"X":41872,"RHEA_ID":40184,"compounds":"O2 + tetradecanoyl-CoA => (2E)-tetradecenoyl-CoA + H2O2"}
{"X":41873,"RHEA_ID":40185,"compounds":"(2E)-tetradecenoyl-CoA + H2O2 => O2 + tetradecanoyl-CoA"}
{"X":41874,"RHEA_ID":40186,"compounds":"O2 + tetradecanoyl-CoA <=> (2E)-tetradecenoyl-CoA + H2O2"}
{"X":41875,"RHEA_ID":40187,"compounds":"(2E)-octenoyl-CoA + H2O = (3R)-hydroxyoctanoyl-CoA"}
{"X":41876,"RHEA_ID":40188,"compounds":"(2E)-octenoyl-CoA + H2O => (3R)-hydroxyoctanoyl-CoA"}
{"X":41877,"RHEA_ID":40189,"compounds":"(3R)-hydroxyoctanoyl-CoA => (2E)-octenoyl-CoA + H2O"}
{"X":41878,"RHEA_ID":40190,"compounds":"(2E)-octenoyl-CoA + H2O <=> (3R)-hydroxyoctanoyl-CoA"}
{"X":41879,"RHEA_ID":40191,"compounds":"(3R)-hydroxyoctanoyl-CoA + NAD(+) = 3-oxooctanoyl-CoA + H(+) + NADH"}
{"X":41880,"RHEA_ID":40192,"compounds":"(3R)-hydroxyoctanoyl-CoA + NAD(+) => 3-oxooctanoyl-CoA + H(+) + NADH"}
{"X":41881,"RHEA_ID":40193,"compounds":"3-oxooctanoyl-CoA + H(+) + NADH => (3R)-hydroxyoctanoyl-CoA + NAD(+)"}
{"X":41882,"RHEA_ID":50167,"compounds":"(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41883,"RHEA_ID":50168,"compounds":"N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycine"}
{"X":41884,"RHEA_ID":50169,"compounds":"N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 => N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycine"}
{"X":41885,"RHEA_ID":50170,"compounds":"N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycine => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2"}
{"X":41886,"RHEA_ID":50171,"compounds":"N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 <=> N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycine"}
{"X":41887,"RHEA_ID":50172,"compounds":"N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-alanine"}
{"X":41888,"RHEA_ID":40200,"DIRECTION":"LR","MASTER_ID":40199,"metacyc":"RXN-16398","compounds":"hexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 16-hydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41889,"RHEA_ID":40201,"compounds":"16-hydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => hexadecanoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":41890,"RHEA_ID":50175,"compounds":"N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 <=> N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-alanine"}
{"X":41891,"RHEA_ID":50176,"compounds":"N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-gamma-aminobutanoate"}
{"X":41892,"RHEA_ID":40204,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate => 14-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41893,"RHEA_ID":40205,"compounds":"14-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate"}
{"X":41894,"RHEA_ID":40206,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate <=> 14-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41895,"RHEA_ID":50180,"compounds":"N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-gamma-aminobutanoate"}
{"X":41896,"RHEA_ID":50181,"compounds":"N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 => N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-gamma-aminobutanoate"}
{"X":41897,"RHEA_ID":40209,"compounds":"(3S)-hydroxytetradecanedioyl-CoA => (2E)-tetradecenedioyl-CoA + H2O"}
{"X":41898,"RHEA_ID":40210,"compounds":"(2E)-tetradecenedioyl-CoA + H2O <=> (3S)-hydroxytetradecanedioyl-CoA"}
{"X":41899,"RHEA_ID":50184,"compounds":"N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-alanine"}
{"X":41900,"RHEA_ID":50185,"compounds":"N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 => N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-alanine"}
{"X":41901,"RHEA_ID":40213,"compounds":"3-oxotetradecanedioyl-CoA + H(+) + NADH => (3S)-hydroxytetradecanedioyl-CoA + NAD(+)"}
{"X":41902,"RHEA_ID":40214,"compounds":"(3S)-hydroxytetradecanedioyl-CoA + NAD(+) <=> 3-oxotetradecanedioyl-CoA + H(+) + NADH"}
{"X":41903,"RHEA_ID":50188,"compounds":"N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycine"}
{"X":41904,"RHEA_ID":40216,"compounds":"FADH2 + O2 => FAD + H(+) + H2O2"}
{"X":41905,"RHEA_ID":40217,"compounds":"FAD + H(+) + H2O2 => FADH2 + O2"}
{"X":41906,"RHEA_ID":40218,"compounds":"FADH2 + O2 <=> FAD + H(+) + H2O2"}
{"X":41907,"RHEA_ID":50192,"DIRECTION":"UN","MASTER_ID":50192,"ec":"2.4.2.26","compounds":"L-seryl-[protein] + UDP-alpha-D-xylose = 3-O-(beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP"}
{"X":41908,"RHEA_ID":50193,"DIRECTION":"LR","MASTER_ID":50192,"metacyc":"2.4.2.26-RXN","compounds":"L-seryl-[protein] + UDP-alpha-D-xylose => 3-O-(beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP"}
{"X":41909,"RHEA_ID":40221,"compounds":"CoA + H(+) + malonate => H2O + malonyl-CoA"}
{"X":41910,"RHEA_ID":40222,"compounds":"H2O + malonyl-CoA <=> CoA + H(+) + malonate"}
{"X":41911,"RHEA_ID":50196,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O"}
{"X":41912,"RHEA_ID":46805,"DIRECTION":"LR","MASTER_ID":46804,"metacyc":"RXN-16336","compounds":"a (4E,8E)-4-sphinga-4,8-dienine ceramide + S-adenosyl-L-methionine => a 9-methyl-(4E,8E)-sphinga-4,8-dienine ceramide + H(+) + S-adenosyl-L-homocysteine"}
{"X":41913,"RHEA_ID":40225,"compounds":"4,8-dimethylnonanoate + CoA + H(+) => 4,8-dimethylnonanoyl-CoA + H2O"}
{"X":41914,"RHEA_ID":40226,"compounds":"4,8-dimethylnonanoyl-CoA + H2O <=> 4,8-dimethylnonanoate + CoA + H(+)"}
{"X":41915,"RHEA_ID":43514,"compounds":"2-carboxy-5-formylfuran + H(+) + H2O2 => 2-(dihydroxymethyl)-5-formylfuran + O2"}
{"X":41916,"RHEA_ID":46809,"DIRECTION":"LR","MASTER_ID":46808,"metacyc":"RXN-16429","compounds":"[trehalose-6-phosphate synthase]-L-cysteine + S-adenosyl-L-methionine => [trehalose-6-phosphate synthase]-S-methyl-L-cysteine + H(+) + S-adenosyl-L-homocysteine"}
{"X":41917,"RHEA_ID":40229,"compounds":"A47934 + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + desulfo-A47934"}
{"X":41918,"RHEA_ID":50203,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 <=> (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O"}
{"X":41919,"RHEA_ID":50204,"compounds":"(18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 = (5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate"}
{"X":41920,"RHEA_ID":40232,"DIRECTION":"LR","MASTER_ID":40231,"metacyc":"CHOLESTANETETRAOL-26-DEHYDROGENASE-RXN","compounds":"(25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + 2 H2O + 2 oxidized [adrenodoxin]"}
{"X":41921,"RHEA_ID":40233,"compounds":"(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + 2 H2O + 2 oxidized [adrenodoxin] => (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}
{"X":41922,"RHEA_ID":50207,"compounds":"(18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 <=> (5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate"}
{"X":41923,"RHEA_ID":50208,"compounds":"cortisol + NAD(+) = cortisone + H(+) + NADH"}
{"X":41924,"RHEA_ID":40236,"compounds":"coenzyme B + coenzyme M + fumarate => coenzyme M-coenzyme B heterodisulfide + succinate"}
{"X":41925,"RHEA_ID":40237,"compounds":"coenzyme M-coenzyme B heterodisulfide + succinate => coenzyme B + coenzyme M + fumarate"}
{"X":41926,"RHEA_ID":50211,"compounds":"cortisol + NAD(+) <=> cortisone + H(+) + NADH"}
{"X":41927,"RHEA_ID":40239,"compounds":"ATP + CoA + dodecanedioate = AMP + diphosphate + dodecanedioyl-CoA"}
{"X":41928,"RHEA_ID":40240,"compounds":"ATP + CoA + dodecanedioate => AMP + diphosphate + dodecanedioyl-CoA"}
{"X":41929,"RHEA_ID":40241,"compounds":"AMP + diphosphate + dodecanedioyl-CoA => ATP + CoA + dodecanedioate"}
{"X":41930,"RHEA_ID":40242,"compounds":"ATP + CoA + dodecanedioate <=> AMP + diphosphate + dodecanedioyl-CoA"}
{"X":41931,"RHEA_ID":50216,"compounds":"(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = (8S)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate"}
{"X":41932,"RHEA_ID":40244,"compounds":"(3R)-hydroxyhexadecanoyl-CoA + NAD(+) => 3-oxohexadecanoyl-CoA + H(+) + NADH"}
{"X":41933,"RHEA_ID":40245,"compounds":"3-oxohexadecanoyl-CoA + H(+) + NADH => (3R)-hydroxyhexadecanoyl-CoA + NAD(+)"}
{"X":41934,"RHEA_ID":40246,"compounds":"(3R)-hydroxyhexadecanoyl-CoA + NAD(+) <=> 3-oxohexadecanoyl-CoA + H(+) + NADH"}
{"X":41935,"RHEA_ID":50220,"compounds":"(S)-demethyl-4-deoxygadusol = (R)-demethyl-4-deoxygadusol"}
{"X":41936,"RHEA_ID":40248,"DIRECTION":"LR","MASTER_ID":40247,"metacyc":"RXN-14856","compounds":"H2O + rhodomycin D => 10-carboxy-13-deoxycarminomycin + H(+) + methanol"}
{"X":41937,"RHEA_ID":40249,"compounds":"10-carboxy-13-deoxycarminomycin + H(+) + methanol => H2O + rhodomycin D"}
{"X":41938,"RHEA_ID":50223,"DIRECTION":"BI","MASTER_ID":50220,"metacyc":"RXN-17895","compounds":"(S)-demethyl-4-deoxygadusol <=> (R)-demethyl-4-deoxygadusol"}
{"X":41939,"RHEA_ID":40251,"compounds":"4-O-methylrhodomycin D + H2O = 10-carboxy-13-deoxydaunorubicin + H(+) + methanol"}
{"X":41940,"RHEA_ID":40252,"DIRECTION":"LR","MASTER_ID":40251,"metacyc":"RXN-14861","compounds":"4-O-methylrhodomycin D + H2O => 10-carboxy-13-deoxydaunorubicin + H(+) + methanol"}
{"X":41941,"RHEA_ID":40253,"compounds":"10-carboxy-13-deoxydaunorubicin + H(+) + methanol => 4-O-methylrhodomycin D + H2O"}
{"X":41942,"RHEA_ID":40254,"compounds":"4-O-methylrhodomycin D + H2O <=> 10-carboxy-13-deoxydaunorubicin + H(+) + methanol"}
{"X":41943,"RHEA_ID":50228,"DIRECTION":"UN","MASTER_ID":50228,"ec":"1.14.14.27","compounds":"FADH2 + O2 + resorcinol = benzene-1,2,4-triol + FAD + H(+) + H2O"}
{"X":41944,"RHEA_ID":40256,"compounds":"(2E)-hexadecenedioyl-CoA + H2O => (3R)-hydroxyhexadecanedioyl-CoA"}
{"X":41945,"RHEA_ID":40257,"compounds":"(3R)-hydroxyhexadecanedioyl-CoA => (2E)-hexadecenedioyl-CoA + H2O"}
{"X":41946,"RHEA_ID":40258,"compounds":"(2E)-hexadecenedioyl-CoA + H2O <=> (3R)-hydroxyhexadecanedioyl-CoA"}
{"X":41947,"RHEA_ID":40259,"compounds":"(2E)-hexadecenedioyl-CoA + H2O = (3S)-hydroxyhexadecanedioyl-CoA"}
{"X":41948,"RHEA_ID":50233,"DIRECTION":"LR","MASTER_ID":50232,"metacyc":"RXN-17523","compounds":"8 H(+) + heme b + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => biliverdin IXalpha + CO + Fe(2+) + 3 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":41949,"RHEA_ID":40261,"compounds":"(3S)-hydroxyhexadecanedioyl-CoA => (2E)-hexadecenedioyl-CoA + H2O"}
{"X":41950,"RHEA_ID":40262,"compounds":"(2E)-hexadecenedioyl-CoA + H2O <=> (3S)-hydroxyhexadecanedioyl-CoA"}
{"X":41951,"RHEA_ID":50236,"compounds":"O2 + pregnenolone + reduced [NADPH--hemoprotein reductase] = 17alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41952,"RHEA_ID":50237,"compounds":"O2 + pregnenolone + reduced [NADPH--hemoprotein reductase] => 17alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41953,"RHEA_ID":40265,"compounds":"3-oxohexadecanedioyl-CoA + H(+) + NADH => (3R)-hydroxyhexadecanedioyl-CoA + NAD(+)"}
{"X":41954,"RHEA_ID":40266,"compounds":"(3R)-hydroxyhexadecanedioyl-CoA + NAD(+) <=> 3-oxohexadecanedioyl-CoA + H(+) + NADH"}
{"X":41955,"RHEA_ID":50240,"DIRECTION":"UN","MASTER_ID":50240,"ec":"4.2.2.1","compounds":"[hyaluronan](n) = n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine + H2O"}
{"X":41956,"RHEA_ID":50241,"DIRECTION":"LR","MASTER_ID":50240,"metacyc":"HYALURONATE-LYASE-RXN","compounds":"[hyaluronan](n) => n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine + H2O"}
{"X":41957,"RHEA_ID":40269,"compounds":"3-oxohexadecanedioyl-CoA + H(+) + NADH => (3S)-hydroxyhexadecanedioyl-CoA + NAD(+)"}
{"X":41958,"RHEA_ID":40270,"compounds":"(3S)-hydroxyhexadecanedioyl-CoA + NAD(+) <=> 3-oxohexadecanedioyl-CoA + H(+) + NADH"}
{"X":41959,"RHEA_ID":50244,"DIRECTION":"UN","MASTER_ID":50244,"ec":"1.14.14.32","compounds":"17alpha-hydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase] = 3beta-hydroxyandrost-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41960,"RHEA_ID":40273,"compounds":"(2E)-tetradecenedioyl-CoA + H2O2 => O2 + tetradecanedioyl-CoA"}
{"X":41961,"RHEA_ID":40274,"compounds":"O2 + tetradecanedioyl-CoA <=> (2E)-tetradecenedioyl-CoA + H2O2"}
{"X":41962,"RHEA_ID":60309,"DIRECTION":"LR","MASTER_ID":60308,"metacyc":"RXN-20652","compounds":"L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-methionine => 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-homocysteine"}
{"X":41963,"RHEA_ID":40276,"compounds":"hexadecanedioyl-CoA + O2 => (2E)-hexadecenedioyl-CoA + H2O2"}
{"X":41964,"RHEA_ID":40277,"compounds":"(2E)-hexadecenedioyl-CoA + H2O2 => hexadecanedioyl-CoA + O2"}
{"X":41965,"RHEA_ID":40278,"compounds":"hexadecanedioyl-CoA + O2 <=> (2E)-hexadecenedioyl-CoA + H2O2"}
{"X":41966,"RHEA_ID":60313,"DIRECTION":"LR","MASTER_ID":60312,"metacyc":"RXN-20601","compounds":"L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":41967,"RHEA_ID":50252,"compounds":"an acyl-CoA + H(+) + malonyl-CoA = a 3-oxoacyl-CoA + CO2 + CoA"}
{"X":41968,"RHEA_ID":40281,"compounds":"CoA + O-dodecanoyl-R-carnitine => (R)-carnitine + dodecanoyl-CoA"}
{"X":41969,"RHEA_ID":40282,"DIRECTION":"BI","MASTER_ID":40279,"metacyc":"RXN-18373","compounds":"(R)-carnitine + dodecanoyl-CoA <=> CoA + O-dodecanoyl-R-carnitine"}
{"X":41970,"RHEA_ID":50255,"compounds":"an acyl-CoA + H(+) + malonyl-CoA <=> a 3-oxoacyl-CoA + CO2 + CoA"}
{"X":41971,"RHEA_ID":50256,"compounds":"cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 25-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41972,"RHEA_ID":40285,"compounds":"CoA + O-hexadecanedioyl-L-carnitine => (R)-carnitine + hexadecanedioyl-CoA"}
{"X":41973,"RHEA_ID":40286,"compounds":"(R)-carnitine + hexadecanedioyl-CoA <=> CoA + O-hexadecanedioyl-L-carnitine"}
{"X":41974,"RHEA_ID":50259,"compounds":"cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 25-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41975,"RHEA_ID":50260,"compounds":"11(S)-hydroxy-14(S),15(S)-epoxy-(5Z,8Z,12E)-eicosatrienoate + glutathione = (11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate"}
{"X":41976,"RHEA_ID":40289,"compounds":"AMP + decanedioyl-CoA + diphosphate => ATP + CoA + decanedioate"}
{"X":41977,"RHEA_ID":40290,"compounds":"ATP + CoA + decanedioate <=> AMP + decanedioyl-CoA + diphosphate"}
{"X":41978,"RHEA_ID":40291,"compounds":"ATP + CoA + tetradecanedioate = AMP + diphosphate + tetradecanedioyl-CoA"}
{"X":41979,"RHEA_ID":50264,"compounds":"cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 26-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":41980,"RHEA_ID":40293,"compounds":"AMP + diphosphate + tetradecanedioyl-CoA => ATP + CoA + tetradecanedioate"}
{"X":41981,"RHEA_ID":40294,"compounds":"ATP + CoA + tetradecanedioate <=> AMP + diphosphate + tetradecanedioyl-CoA"}
{"X":41982,"RHEA_ID":40295,"compounds":"ATP + CoA + hexadecanedioate = AMP + diphosphate + hexadecanedioyl-CoA"}
{"X":41983,"RHEA_ID":50268,"compounds":"(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate = (5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O"}
{"X":41984,"RHEA_ID":40297,"compounds":"AMP + diphosphate + hexadecanedioyl-CoA => ATP + CoA + hexadecanedioate"}
{"X":41985,"RHEA_ID":40298,"compounds":"ATP + CoA + hexadecanedioate <=> AMP + diphosphate + hexadecanedioyl-CoA"}
{"X":41986,"RHEA_ID":50271,"compounds":"(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate <=> (5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O"}
{"X":41987,"RHEA_ID":50272,"compounds":"(5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O = resolvin E1"}
{"X":41988,"RHEA_ID":40301,"compounds":"erythronolide B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 6-deoxyerythronolide B + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":41989,"RHEA_ID":50274,"compounds":"resolvin E1 => (5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O"}
{"X":41990,"RHEA_ID":50275,"compounds":"(5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O <=> resolvin E1"}
{"X":41991,"RHEA_ID":50276,"compounds":"(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (12S)-hydroperoxy-(14R,15S)-epoxy-(5Z,8Z,10E)-eicosatrienoate"}
{"X":41992,"RHEA_ID":40305,"compounds":"(2E)-dodecenedioyl-CoA + AH2 => A + dodecanedioyl-CoA"}
{"X":41993,"RHEA_ID":40306,"compounds":"A + dodecanedioyl-CoA <=> (2E)-dodecenedioyl-CoA + AH2"}
{"X":41994,"RHEA_ID":50279,"compounds":"(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 <=> (12S)-hydroperoxy-(14R,15S)-epoxy-(5Z,8Z,10E)-eicosatrienoate"}
{"X":41995,"RHEA_ID":50280,"compounds":"(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (5S)-hydroperoxy-(14R,15S)-epoxy-(6E,8Z,11Z)-eicosatrienoate"}
{"X":41996,"RHEA_ID":40309,"compounds":"(2E)-decenedioyl-CoA + AH2 => A + decanedioyl-CoA"}
{"X":41997,"RHEA_ID":40310,"compounds":"A + decanedioyl-CoA <=> (2E)-decenedioyl-CoA + AH2"}
{"X":41998,"RHEA_ID":50283,"compounds":"(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 <=> (5S)-hydroperoxy-(14R,15S)-epoxy-(6E,8Z,11Z)-eicosatrienoate"}
{"X":41999,"RHEA_ID":50284,"compounds":"(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (12S)-hydroperoxy-(14S,15R)-epoxy-(5Z,8Z,10E)-eicosatrienoate"}
{"X":42000,"RHEA_ID":40313,"compounds":"(2E)-hexenoyl-CoA + H2O2 => hexanoyl-CoA + O2"}
{"X":42001,"RHEA_ID":40314,"compounds":"hexanoyl-CoA + O2 <=> (2E)-hexenoyl-CoA + H2O2"}
{"X":42002,"RHEA_ID":50287,"compounds":"(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 <=> (12S)-hydroperoxy-(14S,15R)-epoxy-(5Z,8Z,10E)-eicosatrienoate"}
{"X":42003,"RHEA_ID":40316,"compounds":"glutaryl-CoA + O2 => (2E)-glutaconyl-CoA + H2O2"}
{"X":42004,"RHEA_ID":50289,"compounds":"(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 => (8S)-hydroperoxy-(14S,15R)-epoxy-(5Z,9E,11Z)-eicosatrienoate"}
{"X":42005,"RHEA_ID":40318,"compounds":"glutaryl-CoA + O2 <=> (2E)-glutaconyl-CoA + H2O2"}
{"X":42006,"RHEA_ID":50291,"compounds":"(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 <=> (8S)-hydroperoxy-(14S,15R)-epoxy-(5Z,9E,11Z)-eicosatrienoate"}
{"X":42007,"RHEA_ID":40320,"compounds":"O2 + tetracosanoyl-CoA => (2E)-tetracosenoyl-CoA + H2O2"}
{"X":42008,"RHEA_ID":50293,"DIRECTION":"LR","MASTER_ID":50292,"metacyc":"RXN-18778","compounds":"all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => all-trans-3,4-didehydroretinol + 2 H2O + 2 oxidized [adrenodoxin]"}
{"X":42009,"RHEA_ID":40322,"compounds":"O2 + tetracosanoyl-CoA <=> (2E)-tetracosenoyl-CoA + H2O2"}
{"X":42010,"RHEA_ID":40323,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":42011,"RHEA_ID":40324,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":42012,"RHEA_ID":50297,"compounds":"N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + O2 + reduced [NADPH--hemoprotein reductase] => 2-oxo-N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":42013,"RHEA_ID":40326,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":42014,"RHEA_ID":40327,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":42015,"RHEA_ID":50300,"compounds":"all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = all-trans-4-hydroxyretinol + H2O + 2 oxidized [adrenodoxin]"}
{"X":42016,"RHEA_ID":50301,"compounds":"all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => all-trans-4-hydroxyretinol + H2O + 2 oxidized [adrenodoxin]"}
{"X":42017,"RHEA_ID":40330,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":42018,"RHEA_ID":40331,"compounds":"1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP = 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":42019,"RHEA_ID":50304,"compounds":"O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 21-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":42020,"RHEA_ID":40333,"compounds":"1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+) => 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP"}
{"X":42021,"RHEA_ID":40334,"compounds":"1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP <=> 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":42022,"RHEA_ID":40335,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":42023,"RHEA_ID":50308,"compounds":"17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] = 11-deoxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":42024,"RHEA_ID":50309,"compounds":"17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] => 11-deoxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":42025,"RHEA_ID":40338,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":42026,"RHEA_ID":40339,"compounds":"1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + ATP = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":42027,"RHEA_ID":40340,"compounds":"1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + ATP => 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":42028,"RHEA_ID":50313,"DIRECTION":"LR","MASTER_ID":50312,"metacyc":"RXN-14985","compounds":"2-oxopentanoate + H(+) => butanal + CO2"}
{"X":42029,"RHEA_ID":40342,"compounds":"1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + ATP <=> 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":42030,"RHEA_ID":40343,"compounds":"3-oxohexadecanedioyl-CoA + CoA = acetyl-CoA + tetradecanedioyl-CoA"}
{"X":42031,"RHEA_ID":50316,"compounds":"ethyl octadecanoate + H2O = ethanol + H(+) + octadecanoate"}
{"X":42032,"RHEA_ID":50317,"compounds":"ethyl octadecanoate + H2O => ethanol + H(+) + octadecanoate"}
{"X":42033,"RHEA_ID":40346,"compounds":"3-oxohexadecanedioyl-CoA + CoA <=> acetyl-CoA + tetradecanedioyl-CoA"}
{"X":42034,"RHEA_ID":40347,"compounds":"3-oxotetradecanedioyl-CoA + CoA = acetyl-CoA + dodecanedioyl-CoA"}
{"X":42035,"RHEA_ID":50320,"compounds":"a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] = 1-[(9R,10S)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":42036,"RHEA_ID":50321,"compounds":"a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] => 1-[(9R,10S)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":42037,"RHEA_ID":40350,"compounds":"3-oxotetradecanedioyl-CoA + CoA <=> acetyl-CoA + dodecanedioyl-CoA"}
{"X":42038,"RHEA_ID":40351,"compounds":"1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP = 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":42039,"RHEA_ID":50324,"compounds":"a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] = 1-[(9S,10R)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":42040,"RHEA_ID":50325,"compounds":"a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] => 1-[(9S,10R)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":42041,"RHEA_ID":40354,"compounds":"1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP <=> 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":42042,"RHEA_ID":40355,"compounds":"1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + ATP = 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":42043,"RHEA_ID":50328,"compounds":"a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] = 1-[8-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":42044,"RHEA_ID":50329,"compounds":"a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] => 1-[8-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":42045,"RHEA_ID":40358,"compounds":"1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + ATP <=> 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":42046,"RHEA_ID":40359,"compounds":"1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":42047,"RHEA_ID":40360,"compounds":"1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + ATP => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":42048,"RHEA_ID":50333,"compounds":"a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] => 1-[11-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":42049,"RHEA_ID":40362,"compounds":"1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + ATP <=> 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":42050,"RHEA_ID":40363,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+)"}
{"X":42051,"RHEA_ID":50336,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + triacontanoate = H(+) + H2O + omega-hydroxy-triacontanoate + oxidized [NADPH--hemoprotein reductase]"}
{"X":42052,"RHEA_ID":60399,"compounds":"Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O <=> Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine"}
{"X":42053,"RHEA_ID":40366,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+)"}
{"X":42054,"RHEA_ID":40367,"compounds":"1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP = 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+)"}
{"X":42055,"RHEA_ID":50340,"DIRECTION":"UN","MASTER_ID":50340,"ec":"1.14.15.19","metacyc":"RXN-17520","compounds":"2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + testosterone = 1alpha-hydroxytestosterone + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":42056,"RHEA_ID":50341,"compounds":"2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + testosterone => 1alpha-hydroxytestosterone + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":42057,"RHEA_ID":40370,"compounds":"1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP <=> 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+)"}
{"X":42058,"RHEA_ID":40371,"DIRECTION":"UN","MASTER_ID":40371,"ec":"2.7.1.181","compounds":"alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-di-trans,octa-cis-undecaprenol + ATP = 3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-di-trans,octa-cis-undecaprenol + ADP + H(+)"}
{"X":42059,"RHEA_ID":50344,"DIRECTION":"UN","MASTER_ID":50344,"ec":"2.3.1.252","compounds":"3 (S)-methylmalonyl-CoA + a holo-[mycolipanoate synthase] + a long-chain fatty acyl-CoA + 9 H(+) + 6 NADPH = a long-chain mycolipanoyl-[mycolipanoate synthase] + 3 CO2 + 4 CoA + 3 H2O + 6 NADP(+)"}
{"X":42060,"RHEA_ID":50345,"DIRECTION":"LR","MASTER_ID":50344,"metacyc":"RXN-17254","compounds":"3 (S)-methylmalonyl-CoA + a holo-[mycolipanoate synthase] + a long-chain fatty acyl-CoA + 9 H(+) + 6 NADPH => a long-chain mycolipanoyl-[mycolipanoate synthase] + 3 CO2 + 4 CoA + 3 H2O + 6 NADP(+)"}
{"X":42061,"RHEA_ID":50346,"compounds":"a long-chain mycolipanoyl-[mycolipanoate synthase] + 3 CO2 + 4 CoA + 3 H2O + 6 NADP(+) => 3 (S)-methylmalonyl-CoA + a holo-[mycolipanoate synthase] + a long-chain fatty acyl-CoA + 9 H(+) + 6 NADPH"}
{"X":42062,"RHEA_ID":40375,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)"}
{"X":42063,"RHEA_ID":50348,"DIRECTION":"UN","MASTER_ID":50348,"ec":"2.4.99.18","compounds":"alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] = dolichyl diphosphate + H(+) + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein]"}
{"X":42064,"RHEA_ID":50349,"DIRECTION":"LR","MASTER_ID":50348,"metacyc":"2.4.1.119-RXN","compounds":"alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] => dolichyl diphosphate + H(+) + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein]"}
{"X":42065,"RHEA_ID":40378,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + ATP <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)"}
{"X":42066,"RHEA_ID":40379,"compounds":"1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP = 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)"}
{"X":42067,"RHEA_ID":50352,"DIRECTION":"UN","MASTER_ID":50352,"ec":"2.3.1.111","compounds":"3 (R)-methylmalonyl-CoA + a long-chain acyl-[mycocerosate synthase] + 9 H(+) + 6 NADPH = a trimethylated-mycocerosoyl-[mycocerosate synthase] + 3 CO2 + 3 CoA + 3 H2O + 6 NADP(+)"}
{"X":42068,"RHEA_ID":50353,"DIRECTION":"LR","MASTER_ID":50352,"metacyc":"RXN-18051","compounds":"3 (R)-methylmalonyl-CoA + a long-chain acyl-[mycocerosate synthase] + 9 H(+) + 6 NADPH => a trimethylated-mycocerosoyl-[mycocerosate synthase] + 3 CO2 + 3 CoA + 3 H2O + 6 NADP(+)"}
{"X":42069,"RHEA_ID":40382,"compounds":"1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP <=> 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)"}
{"X":42070,"RHEA_ID":40383,"compounds":"1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)"}
{"X":42071,"RHEA_ID":50356,"DIRECTION":"UN","MASTER_ID":50356,"ec":"1.14.13.233","compounds":"4-hydroxy-6-methylpretetramide + NADPH + O2 = 4-dedimethylamino-4-oxo-anhydrotetracycline + H2O + NADP(+)"}
{"X":42072,"RHEA_ID":60431,"compounds":"(indol-3-yl)acetyl-L-aspartate + H2O <=> (indol-3-yl)acetate + L-aspartate"}
{"X":42073,"RHEA_ID":40386,"compounds":"1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP <=> 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)"}
{"X":42074,"RHEA_ID":40387,"compounds":"1,2-di-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP = 1,2-di(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)"}
{"X":42075,"RHEA_ID":50360,"DIRECTION":"UN","MASTER_ID":50360,"ec":"1.1.3.49","compounds":"(R)-mandelonitrile + O2 = benzoyl cyanide + H2O2"}
{"X":42076,"RHEA_ID":50361,"DIRECTION":"LR","MASTER_ID":50360,"metacyc":"RXN-17966","compounds":"(R)-mandelonitrile + O2 => benzoyl cyanide + H2O2"}
{"X":42077,"RHEA_ID":40390,"compounds":"1,2-di-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP <=> 1,2-di(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)"}
{"X":42078,"RHEA_ID":40391,"compounds":"1-O-alkyl-2-acyl-sn-glycerol + an acyl-CoA = 1-O-alkyl-2,3-diacyl-sn-glycerol + CoA"}
{"X":42079,"RHEA_ID":50364,"DIRECTION":"UN","MASTER_ID":50364,"ec":"1.14.19.73","compounds":"(S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase] = (S)-nandinine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":42080,"RHEA_ID":50365,"compounds":"(S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase] => (S)-nandinine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":42081,"RHEA_ID":50366,"compounds":"(S)-nandinine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":42082,"RHEA_ID":40395,"DIRECTION":"UN","MASTER_ID":40395,"ec":"1.6.3.5","compounds":"1,2-dihydro-beta-NAD + H(+) + O2 = H2O2 + NAD(+)"}
{"X":42083,"RHEA_ID":40396,"compounds":"1,2-dihydro-beta-NAD + H(+) + O2 => H2O2 + NAD(+)"}
{"X":42084,"RHEA_ID":50369,"DIRECTION":"LR","MASTER_ID":50368,"metacyc":"RXN-17619","compounds":"2-methylbutan-2-ol + H(+) + NADPH + O2 => 3-hydroxy-3-methylbut-1-ene + 2 H2O + NADP(+)"}
{"X":42085,"RHEA_ID":40399,"DIRECTION":"UN","MASTER_ID":40399,"ec":"1.6.3.5","compounds":"1,2-dihydro-beta-NADP + H(+) + O2 = H2O2 + NADP(+)"}
{"X":42086,"RHEA_ID":50372,"compounds":"an N-acylsphingoid base 1-phosphate(in) = an N-acylsphingoid base 1-phosphate(out)"}
{"X":42087,"RHEA_ID":50373,"compounds":"an N-acylsphingoid base 1-phosphate(in) => an N-acylsphingoid base 1-phosphate(out)"}
{"X":42088,"RHEA_ID":50374,"compounds":"an N-acylsphingoid base 1-phosphate(out) => an N-acylsphingoid base 1-phosphate(in)"}
{"X":42089,"RHEA_ID":40403,"compounds":"1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":42090,"RHEA_ID":50376,"compounds":"a ceramide(in) + ATP + H2O = a ceramide(out) + ADP + H(+) + phosphate"}
{"X":42091,"RHEA_ID":40405,"compounds":"1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP"}
{"X":42092,"RHEA_ID":40406,"compounds":"1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP <=> 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":42093,"RHEA_ID":50379,"compounds":"a ceramide(in) + ATP + H2O <=> a ceramide(out) + ADP + H(+) + phosphate"}
{"X":42094,"RHEA_ID":40408,"compounds":"1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP => 1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":42095,"RHEA_ID":40409,"compounds":"1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP"}
{"X":42096,"RHEA_ID":40410,"compounds":"1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP <=> 1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":42097,"RHEA_ID":60469,"compounds":"3',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) => 3',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)"}
{"X":42098,"RHEA_ID":50384,"DIRECTION":"UN","MASTER_ID":50384,"ec":"1.3.98.4","compounds":"H(+) + oxidized coenzyme F420-(gamma-Glu)(n) + tetracycline = 5a,11a-dehydrotetracycline + reduced coenzyme F420-(gamma-Glu)(n)"}
{"X":42099,"RHEA_ID":40413,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-CDP + myo-inositol"}
{"X":42100,"RHEA_ID":40414,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-CDP + myo-inositol <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)"}
{"X":42101,"RHEA_ID":60473,"compounds":"5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) + 5-formyltetrahydrofolate(out) => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out) + 5-formyltetrahydrofolate(in)"}
{"X":42102,"RHEA_ID":50388,"DIRECTION":"UN","MASTER_ID":50388,"ec":"1.14.13.234","compounds":"5a,11a-dehydrotetracycline + H(+) + NADPH + O2 = 5a,11a-dehydrooxytetracycline + H2O + NADP(+)"}
{"X":42103,"RHEA_ID":50389,"DIRECTION":"LR","MASTER_ID":50388,"metacyc":"RXN-17976","compounds":"5a,11a-dehydrotetracycline + H(+) + NADPH + O2 => 5a,11a-dehydrooxytetracycline + H2O + NADP(+)"}
{"X":42104,"RHEA_ID":40418,"compounds":"H2O + pristanoyl-CoA <=> 2,6,10,14-tetramethylpentadecanoate + CoA + H(+)"}
{"X":42105,"RHEA_ID":40419,"compounds":"H2O + phytanoyl-CoA = 3,7,11,15-tetramethylhexadecanoate + CoA + H(+)"}
{"X":42106,"RHEA_ID":50392,"DIRECTION":"UN","MASTER_ID":50392,"ec":"1.3.98.4","compounds":"H(+) + oxidized coenzyme F420-(gamma-Glu)(n) + oxytetracycline = 5a,11a-dehydrooxytetracycline + reduced coenzyme F420-(gamma-Glu)(n)"}
{"X":42107,"RHEA_ID":50393,"DIRECTION":"LR","MASTER_ID":50392,"metacyc":"RXN-17975","compounds":"H(+) + oxidized coenzyme F420-(gamma-Glu)(n) + oxytetracycline => 5a,11a-dehydrooxytetracycline + reduced coenzyme F420-(gamma-Glu)(n)"}
{"X":42108,"RHEA_ID":40422,"compounds":"H2O + phytanoyl-CoA <=> 3,7,11,15-tetramethylhexadecanoate + CoA + H(+)"}
{"X":42109,"RHEA_ID":60481,"compounds":"2 UTP => c-di-UMP + 2 diphosphate"}
{"X":42110,"RHEA_ID":40424,"compounds":"(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + AH2 + O2 => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + A + 2 H2O"}
{"X":42111,"RHEA_ID":50397,"DIRECTION":"LR","MASTER_ID":50396,"metacyc":"RXN-17711","compounds":"(2-aminobenzoyl)acetate + H(+) + octanoyl-CoA => 2-heptyl-4(1H)-quinolone + CO2 + CoA + H2O"}
{"X":42112,"RHEA_ID":40426,"compounds":"(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + AH2 + O2 <=> (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + A + 2 H2O"}
{"X":42113,"RHEA_ID":60485,"compounds":"CTP + UTP => cyclic CMP-UMP + 2 diphosphate"}
{"X":42114,"RHEA_ID":40428,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":42115,"RHEA_ID":50401,"DIRECTION":"LR","MASTER_ID":50400,"metacyc":"RXN-17708","compounds":"L-cysteinyl-[PqsC protein] + octanoyl-CoA => CoA + S-octanoyl-L-cysteinyl-[PqsC protein]"}
{"X":42116,"RHEA_ID":40430,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":42117,"RHEA_ID":60505,"DIRECTION":"LR","MASTER_ID":60504,"metacyc":"RXN-11639","compounds":"1D-myo-inositol 3-phosphate + a CDP-1,2-diacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)"}
{"X":42118,"RHEA_ID":40432,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)"}
{"X":42119,"RHEA_ID":60507,"compounds":"1D-myo-inositol 3-phosphate + a CDP-1,2-diacyl-sn-glycerol <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)"}
{"X":42120,"RHEA_ID":40434,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)"}
{"X":42121,"RHEA_ID":60509,"compounds":"a guanosine in mRNA + S-adenosyl-L-methionine => an N(7)-methylguanosine in mRNA + S-adenosyl-L-homocysteine"}
{"X":42122,"RHEA_ID":40436,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => H(+) + hexadecanoate + sn-glycerol 3-phosphocholine"}
{"X":42123,"RHEA_ID":50409,"DIRECTION":"LR","MASTER_ID":50408,"metacyc":"RXN-17705","compounds":"1-(2-aminophenyl)decane-1,3-dione => 2-heptyl-4(1H)-quinolone + H2O"}
{"X":42124,"RHEA_ID":40438,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> H(+) + hexadecanoate + sn-glycerol 3-phosphocholine"}
{"X":42125,"RHEA_ID":60513,"compounds":"a guanosine in miRNA + S-adenosyl-L-methionine => an N(7)-methylguanosine in miRNA + S-adenosyl-L-homocysteine"}
{"X":42126,"RHEA_ID":40440,"DIRECTION":"LR","MASTER_ID":40439,"metacyc":"RXN-15296","compounds":"6-sulfo-D-quinovose => 6-deoxy-6-sulfo-D-fructose"}
{"X":42127,"RHEA_ID":50413,"DIRECTION":"LR","MASTER_ID":50412,"metacyc":"RXN-17898","compounds":"L-leucyl-tRNA(Leu) + N-terminal L-glutamyl-[protein] => H(+) + N-terminal L-leucyl-L-glutamyl-[protein] + tRNA(Leu)"}
{"X":42128,"RHEA_ID":40442,"compounds":"6-sulfo-D-quinovose <=> 6-deoxy-6-sulfo-D-fructose"}
{"X":42129,"RHEA_ID":50415,"compounds":"L-leucyl-tRNA(Leu) + N-terminal L-glutamyl-[protein] <=> H(+) + N-terminal L-leucyl-L-glutamyl-[protein] + tRNA(Leu)"}
{"X":42130,"RHEA_ID":40444,"DIRECTION":"LR","MASTER_ID":40443,"metacyc":"RXN-15297","compounds":"6-deoxy-6-sulfo-D-fructose + ATP => 6-deoxy-6-sulfo-D-fructose 1-phosphate + ADP + H(+)"}
{"X":42131,"RHEA_ID":43732,"compounds":"a triacyl-sn-glycerol + H2O = 1,3-diacyl-sn-glycerol + a fatty acid + H(+)"}
{"X":42132,"RHEA_ID":40446,"compounds":"6-deoxy-6-sulfo-D-fructose + ATP <=> 6-deoxy-6-sulfo-D-fructose 1-phosphate + ADP + H(+)"}
{"X":42133,"RHEA_ID":60521,"compounds":"2 H2O + L-cystine-bis-glycine => 2 glycine + L-cystine"}
{"X":42134,"RHEA_ID":40448,"compounds":"(2R)-pristanoyl-CoA => (2S)-pristanoyl-CoA"}
{"X":42135,"RHEA_ID":50421,"DIRECTION":"LR","MASTER_ID":50420,"metacyc":"RXN-17899","compounds":"L-leucyl-tRNA(Leu) + N-terminal L-aspartyl-[protein] => H(+) + N-terminal L-leucyl-L-aspartyl-[protein] + tRNA(Leu)"}
{"X":42136,"RHEA_ID":40450,"compounds":"(2R)-pristanoyl-CoA <=> (2S)-pristanoyl-CoA"}
{"X":42137,"RHEA_ID":60525,"compounds":"5-hydroxyuridine(34) in tRNA + S-adenosyl-L-methionine => 5-methoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":42138,"RHEA_ID":40452,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphate + H(+)"}
{"X":42139,"RHEA_ID":50425,"compounds":"(8Z,11Z,14Z)-eicosatrienoate + 2 O2 => prostaglandin G1"}
{"X":42140,"RHEA_ID":40454,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphate + H(+)"}
{"X":42141,"RHEA_ID":60557,"DIRECTION":"LR","MASTER_ID":60556,"ecocyc":"RXN0-7253","metacyc":"RXN0-7253","compounds":"uridine(35) in tRNA(Tyr) => pseudouridine(35) in tRNA(Tyr)"}
{"X":42142,"RHEA_ID":40456,"DIRECTION":"LR","MASTER_ID":40455,"reactome":"R-HSA-192056.1","compounds":"(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA => (25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA"}
{"X":42143,"RHEA_ID":50429,"DIRECTION":"LR","MASTER_ID":50428,"metacyc":"RXN-17813","compounds":"methanethiol + S-adenosyl-L-methionine => dimethyl sulfide + H(+) + S-adenosyl-L-homocysteine"}
{"X":42144,"RHEA_ID":40458,"compounds":"(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA <=> (25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA"}
{"X":42145,"RHEA_ID":60561,"compounds":"L-methionyl-[protein] + S-adenosyl-L-methionine => S-adenosyl-L-homocysteine + S-methyl-L-methionyl-[protein]"}
{"X":42146,"RHEA_ID":40460,"DIRECTION":"LR","MASTER_ID":40459,"reactome":"R-HSA-389891.1","compounds":"(2S)-pristanoyl-CoA + O2 => (2E)-pristenoyl-CoA + H2O2"}
{"X":42147,"RHEA_ID":43748,"compounds":"ATP + CoA + hexacosanoate = AMP + diphosphate + hexacosanoyl-CoA"}
{"X":42148,"RHEA_ID":40461,"compounds":"(2E)-pristenoyl-CoA + H2O2 => (2S)-pristanoyl-CoA + O2"}
{"X":42149,"RHEA_ID":60565,"compounds":"2-deoxy-D-glucose + ATP => 2-deoxy-D-glucose 6-phosphate + ADP + H(+)"}
{"X":42150,"RHEA_ID":40463,"compounds":"1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O = (9Z)-octadecenoate + 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+)"}
{"X":42151,"RHEA_ID":50437,"compounds":"prostaglandin H1 => prostaglandin E1"}
{"X":42152,"RHEA_ID":40465,"compounds":"(9Z)-octadecenoate + 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+) => 1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O"}
{"X":42153,"RHEA_ID":50439,"compounds":"prostaglandin H1 <=> prostaglandin E1"}
{"X":42154,"RHEA_ID":40467,"compounds":"1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O = (9Z)-octadecenoate + 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+)"}
{"X":42155,"RHEA_ID":40468,"compounds":"1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O => (9Z)-octadecenoate + 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+)"}
{"X":42156,"RHEA_ID":40469,"compounds":"(9Z)-octadecenoate + 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+) => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O"}
{"X":42157,"RHEA_ID":50443,"compounds":"prostaglandin H1 <=> prostaglandin D1"}
{"X":42158,"RHEA_ID":40471,"compounds":"(2S)-methylpentadecanoyl-CoA + O2 = 2-methyl-(2E)-pentadecenoyl-CoA + H2O2"}
{"X":42159,"RHEA_ID":40472,"compounds":"(2S)-methylpentadecanoyl-CoA + O2 => 2-methyl-(2E)-pentadecenoyl-CoA + H2O2"}
{"X":42160,"RHEA_ID":40473,"compounds":"2-methyl-(2E)-pentadecenoyl-CoA + H2O2 => (2S)-methylpentadecanoyl-CoA + O2"}
{"X":42161,"RHEA_ID":60581,"compounds":"(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":42162,"RHEA_ID":40475,"compounds":"1,2,3-tributanoylglycerol + H2O = butanoate + dibutanoylglycerol + H(+)"}
{"X":42163,"RHEA_ID":40476,"compounds":"1,2,3-tributanoylglycerol + H2O => butanoate + dibutanoylglycerol + H(+)"}
{"X":42164,"RHEA_ID":40477,"compounds":"butanoate + dibutanoylglycerol + H(+) => 1,2,3-tributanoylglycerol + H2O"}
{"X":42165,"RHEA_ID":50451,"compounds":"AH2 + prostaglandin G3 <=> A + H2O + prostaglandin H3"}
{"X":42166,"RHEA_ID":40479,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)"}
{"X":42167,"RHEA_ID":40480,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)"}
{"X":42168,"RHEA_ID":40481,"compounds":"1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O"}
{"X":42169,"RHEA_ID":50455,"compounds":"prostaglandin H3 <=> prostaglandin E3"}
{"X":42170,"RHEA_ID":40483,"compounds":"1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 5-oxopentanoate + H(+)"}
{"X":42171,"RHEA_ID":60611,"compounds":"1-tetradecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + ethanolamine"}
{"X":42172,"RHEA_ID":40485,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + 5-oxopentanoate + H(+) => 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O"}
{"X":42173,"RHEA_ID":40486,"compounds":"1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + 5-oxopentanoate + H(+)"}
{"X":42174,"RHEA_ID":40487,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":42175,"RHEA_ID":50461,"DIRECTION":"LR","MASTER_ID":50460,"metacyc":"RXN-16469","compounds":"a medium chain fatty acid + ATP + holo-[ACP] => a medium-chain fatty acyl-[ACP] + AMP + diphosphate"}
{"X":42176,"RHEA_ID":40489,"compounds":"2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":42177,"RHEA_ID":40490,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":42178,"RHEA_ID":40491,"compounds":"1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+)"}
{"X":42179,"RHEA_ID":50465,"DIRECTION":"LR","MASTER_ID":50464,"metacyc":"RXN-17211","compounds":"4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 24 H(+) + 8 malonyl-CoA + 16 NADPH => 17-(4-hydroxyphenyl)heptadecanoyl-[4-hydroxyphenylalkanoate synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+)"}
{"X":42180,"RHEA_ID":40493,"compounds":"(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+) => 1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O"}
{"X":42181,"RHEA_ID":40494,"compounds":"1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+)"}
{"X":42182,"RHEA_ID":40495,"compounds":"N-[omega-(9Z,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine + O2 = N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine"}
{"X":42183,"RHEA_ID":43784,"DIRECTION":"UN","MASTER_ID":43784,"ec":"2.1.1.286","compounds":"adenosine(2142) in 25S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(2142) in 25S rRNA + S-adenosyl-L-homocysteine"}
{"X":42184,"RHEA_ID":50470,"compounds":"19-(4-hydroxyphenyl)nonadecanoyl-[4-hydroxyphenylalkanoate synthase] + 9 CO2 + 9 CoA + 9 H2O + 18 NADP(+) => 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 27 H(+) + 9 malonyl-CoA + 18 NADPH"}
{"X":42185,"RHEA_ID":40498,"compounds":"N-[omega-(9Z,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine + O2 <=> N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine"}
{"X":42186,"RHEA_ID":50472,"DIRECTION":"UN","MASTER_ID":50472,"ec":"2.3.1.262","compounds":"anthraniloyl-CoA + H(+) + malonyl-CoA = (2-aminobenzoyl)acetyl-CoA + CO2 + CoA"}
{"X":42187,"RHEA_ID":50473,"DIRECTION":"LR","MASTER_ID":50472,"metacyc":"RXN-17710","compounds":"anthraniloyl-CoA + H(+) + malonyl-CoA => (2-aminobenzoyl)acetyl-CoA + CO2 + CoA"}
{"X":42188,"RHEA_ID":40501,"compounds":"(9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-L-serine => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O"}
{"X":42189,"RHEA_ID":40502,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O <=> (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-L-serine"}
{"X":42190,"RHEA_ID":50476,"compounds":"anthraniloyl-CoA + L-cysteinyl-[PqsD protein] = CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein]"}
{"X":42191,"RHEA_ID":40504,"compounds":"N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine => N-[omega-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine"}
{"X":42192,"RHEA_ID":40505,"compounds":"N-[omega-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine => N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine"}
{"X":42193,"RHEA_ID":40506,"compounds":"N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine <=> N-[omega-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine"}
{"X":42194,"RHEA_ID":50480,"DIRECTION":"UN","MASTER_ID":50480,"ec":"2.3.1.254","compounds":"acetyl-CoA + N-terminal L-methionyl-L-aspartyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein]"}
{"X":42195,"RHEA_ID":50481,"DIRECTION":"LR","MASTER_ID":50480,"metacyc":"RXN-17852","compounds":"acetyl-CoA + N-terminal L-methionyl-L-aspartyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein]"}
{"X":42196,"RHEA_ID":40509,"compounds":"a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O"}
{"X":42197,"RHEA_ID":40510,"compounds":"1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O <=> a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":42198,"RHEA_ID":50484,"DIRECTION":"UN","MASTER_ID":50484,"ec":"2.3.1.254","compounds":"acetyl-CoA + N-terminal L-methionyl-L-asparaginyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-asparaginyl-[protein]"}
{"X":42199,"RHEA_ID":40512,"compounds":"2,3-dihydroxypropane-1-sulfonate + NAD(+) => 3-sulfolactaldehyde + H(+) + NADH"}
{"X":42200,"RHEA_ID":40513,"DIRECTION":"RL","MASTER_ID":40511,"ecocyc":"RXN-15299","metacyc":"RXN-15299","compounds":"3-sulfolactaldehyde + H(+) + NADH => 2,3-dihydroxypropane-1-sulfonate + NAD(+)"}
{"X":42201,"RHEA_ID":50487,"compounds":"acetyl-CoA + N-terminal L-methionyl-L-asparaginyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-asparaginyl-[protein]"}
{"X":42202,"RHEA_ID":50488,"DIRECTION":"UN","MASTER_ID":50488,"ec":"2.3.1.254","compounds":"acetyl-CoA + N-terminal L-methionyl-L-glutamyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein]"}
{"X":42203,"RHEA_ID":43808,"compounds":"1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine"}
{"X":42204,"RHEA_ID":50490,"compounds":"CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-glutamyl-[protein]"}
{"X":42205,"RHEA_ID":40518,"compounds":"6-deoxy-6-sulfo-D-fructose 1-phosphate <=> 3-sulfolactaldehyde + dihydroxyacetone phosphate"}
{"X":42206,"RHEA_ID":40519,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":42207,"RHEA_ID":60651,"compounds":"an N-(acyl)-sphingosylphosphoethanolamine <=> an N-(acyl)-sphingosyl-1,3-cyclic phosphate + ethanolamine"}
{"X":42208,"RHEA_ID":40521,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O"}
{"X":42209,"RHEA_ID":40522,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":42210,"RHEA_ID":40523,"DIRECTION":"UN","MASTER_ID":40523,"ec":"1.3.5.1","compounds":"a quinone + succinate = a quinol + fumarate"}
{"X":42211,"RHEA_ID":43816,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}
{"X":42212,"RHEA_ID":40524,"DIRECTION":"LR","MASTER_ID":40523,"metacyc":"RXN-14971","compounds":"a quinone + succinate => a quinol + fumarate"}
{"X":42213,"RHEA_ID":40525,"compounds":"a quinol + fumarate => a quinone + succinate"}
{"X":42214,"RHEA_ID":50500,"DIRECTION":"UN","MASTER_ID":50500,"ec":"2.3.1.255","compounds":"acetyl-CoA + N-terminal L-alanyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[protein]"}
{"X":42215,"RHEA_ID":50501,"DIRECTION":"LR","MASTER_ID":50500,"metacyc":"RXN-17860","compounds":"acetyl-CoA + N-terminal L-alanyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[protein]"}
{"X":42216,"RHEA_ID":40528,"DIRECTION":"LR","MASTER_ID":40527,"ecocyc":"RXN0-5266","metacyc":"RXN0-5266","compounds":"2 a ubiquinol + 4 H(+)(in) + O2(in) => 2 a ubiquinone + 4 H(+)(out) + 2 H2O(in)"}
{"X":42217,"RHEA_ID":40529,"compounds":"2 a ubiquinone + 4 H(+)(out) + 2 H2O(in) => 2 a ubiquinol + 4 H(+)(in) + O2(in)"}
{"X":42218,"RHEA_ID":43824,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphate"}
{"X":42219,"RHEA_ID":50506,"compounds":"CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[protein] => acetyl-CoA + N-terminal L-seryl-[protein]"}
{"X":42220,"RHEA_ID":40533,"compounds":"H2O + neopikromycin + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":42221,"RHEA_ID":50508,"DIRECTION":"UN","MASTER_ID":50508,"ec":"2.3.1.255","compounds":"acetyl-CoA + N-terminal L-valyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-valyl-[protein]"}
{"X":42222,"RHEA_ID":60667,"compounds":"H2O + NADPH <=> NADH + phosphate"}
{"X":42223,"RHEA_ID":50510,"compounds":"CoA + H(+) + N-terminal N(alpha)-acetyl-L-valyl-[protein] => acetyl-CoA + N-terminal L-valyl-[protein]"}
{"X":42224,"RHEA_ID":40537,"compounds":"2 H2O + novapikromycin + 4 oxidized [2Fe-2S]-[ferredoxin] => 4 H(+) + narbomycin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]"}
{"X":42225,"RHEA_ID":50512,"DIRECTION":"UN","MASTER_ID":50512,"ec":"2.3.1.255","compounds":"acetyl-CoA + N-terminal L-cysteinyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-cysteinyl-[protein]"}
{"X":42226,"RHEA_ID":43832,"compounds":"5-hydroxy-3-[(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA = 5-hydroxy-3-[(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate"}
{"X":42227,"RHEA_ID":50514,"compounds":"CoA + H(+) + N-terminal N(alpha)-acetyl-L-cysteinyl-[protein] => acetyl-CoA + N-terminal L-cysteinyl-[protein]"}
{"X":42228,"RHEA_ID":40541,"compounds":"H2O + methymycin + 2 oxidized [2Fe-2S]-[ferredoxin] => 10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":42229,"RHEA_ID":50516,"DIRECTION":"UN","MASTER_ID":50516,"ec":"2.3.1.255","compounds":"acetyl-CoA + N-terminal L-threonyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-threonyl-[protein]"}
{"X":42230,"RHEA_ID":50517,"DIRECTION":"LR","MASTER_ID":50516,"metacyc":"RXN-17864","compounds":"acetyl-CoA + N-terminal L-threonyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-threonyl-[protein]"}
{"X":42231,"RHEA_ID":40544,"DIRECTION":"LR","MASTER_ID":40543,"metacyc":"RXN-15101","compounds":"10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + neomethymycin + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":42232,"RHEA_ID":40545,"compounds":"H2O + neomethymycin + 2 oxidized [2Fe-2S]-[ferredoxin] => 10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":42233,"RHEA_ID":50520,"DIRECTION":"UN","MASTER_ID":50520,"ec":"2.3.1.258","compounds":"acetyl-CoA + N-terminal L-methionyl-L-leucyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein]"}
{"X":42234,"RHEA_ID":60679,"compounds":"(S)-(-)-citronellol + NAD(+) <=> (S)-(-)-citronellal + H(+) + NADH"}
{"X":42235,"RHEA_ID":40548,"compounds":"10-deoxymethymycin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + novamethymycin + 4 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":42236,"RHEA_ID":40549,"compounds":"2 H2O + novamethymycin + 4 oxidized [2Fe-2S]-[ferredoxin] => 10-deoxymethymycin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]"}
{"X":42237,"RHEA_ID":50523,"compounds":"acetyl-CoA + N-terminal L-methionyl-L-leucyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein]"}
{"X":42238,"RHEA_ID":43844,"compounds":"(3beta)-hydroxy-cholest-5-en-26-al + NADPH + O2 = (3beta)-hydroxy-cholest-5-en-26-oate + H2O + NADP(+)"}
{"X":42239,"RHEA_ID":40552,"DIRECTION":"LR","MASTER_ID":40551,"metacyc":"RXN-7569","compounds":"demethylphylloquinol + S-adenosyl-L-methionine => H(+) + phylloquinol + S-adenosyl-L-homocysteine"}
{"X":42240,"RHEA_ID":40553,"compounds":"H(+) + phylloquinol + S-adenosyl-L-homocysteine => demethylphylloquinol + S-adenosyl-L-methionine"}
{"X":42241,"RHEA_ID":40554,"compounds":"demethylphylloquinol + S-adenosyl-L-methionine <=> H(+) + phylloquinol + S-adenosyl-L-homocysteine"}
{"X":42242,"RHEA_ID":43848,"DIRECTION":"UN","MASTER_ID":43848,"ec":"1.20.4.4","compounds":"[thioredoxin]-dithiol + arsenate + H(+) = [thioredoxin]-disulfide + arsenite + H2O"}
{"X":42243,"RHEA_ID":40556,"DIRECTION":"LR","MASTER_ID":40555,"metacyc":"RXN-15230","compounds":"dTDP-beta-L-evernosamine + H(+) + 2 NADPH + 2 O2 => dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 3 H2O + 2 NADP(+)"}
{"X":42244,"RHEA_ID":40557,"compounds":"dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 3 H2O + 2 NADP(+) => dTDP-beta-L-evernosamine + H(+) + 2 NADPH + 2 O2"}
{"X":42245,"RHEA_ID":50530,"compounds":"CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-phenylalanyl-[protein]"}
{"X":42246,"RHEA_ID":43852,"compounds":"H(+) + malonyl-CoA + triacontanoyl-CoA = 3-oxo-dotriacontanoyl-CoA + CO2 + CoA"}
{"X":42247,"RHEA_ID":40560,"DIRECTION":"LR","MASTER_ID":40559,"metacyc":"RXN-15228","compounds":"dTDP-beta-L-evernosamine + NADPH + O2 => dTDP-N-hydroxy-beta-L-evernosamine + H2O + NADP(+)"}
{"X":42248,"RHEA_ID":50532,"DIRECTION":"UN","MASTER_ID":50532,"ec":"2.3.1.256","compounds":"acetyl-CoA + N-terminal L-methionyl-L-tyrosyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein]"}
{"X":42249,"RHEA_ID":50533,"DIRECTION":"LR","MASTER_ID":50532,"metacyc":"RXN-17858","compounds":"acetyl-CoA + N-terminal L-methionyl-L-tyrosyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein]"}
{"X":42250,"RHEA_ID":43856,"compounds":"a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(in) = a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(out)"}
{"X":42251,"RHEA_ID":40564,"DIRECTION":"LR","MASTER_ID":40563,"metacyc":"RXN-15229","compounds":"dTDP-N-hydroxy-beta-L-evernosamine + H(+) + NADPH + O2 => dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 2 H2O + NADP(+)"}
{"X":42252,"RHEA_ID":40565,"compounds":"dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 2 H2O + NADP(+) => dTDP-N-hydroxy-beta-L-evernosamine + H(+) + NADPH + O2"}
{"X":42253,"RHEA_ID":50537,"DIRECTION":"LR","MASTER_ID":50536,"reactome":"R-HSA-2161659.2","compounds":"prostaglandin E2 => H2O + prostaglandin A2"}
{"X":42254,"RHEA_ID":43860,"compounds":"1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(in) = 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(out)"}
{"X":42255,"RHEA_ID":40568,"DIRECTION":"LR","MASTER_ID":40567,"metacyc":"RXN-15231","compounds":"AH2 + dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + O2 => A + dTDP-beta-L-evernitrose + H2O"}
{"X":42256,"RHEA_ID":50540,"compounds":"prostaglandin A2 = prostaglandin C2"}
{"X":42257,"RHEA_ID":40570,"compounds":"AH2 + dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + O2 <=> A + dTDP-beta-L-evernitrose + H2O"}
{"X":42258,"RHEA_ID":50542,"compounds":"prostaglandin C2 => prostaglandin A2"}
{"X":42259,"RHEA_ID":40572,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":42260,"RHEA_ID":50544,"compounds":"prostaglandin C2 = prostaglandin B2"}
{"X":42261,"RHEA_ID":40574,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":42262,"RHEA_ID":50546,"compounds":"prostaglandin B2 => prostaglandin C2"}
{"X":42263,"RHEA_ID":40576,"compounds":"glutaryl-CoA + H2O => CoA + glutarate + H(+)"}
{"X":42264,"RHEA_ID":50548,"compounds":"prostaglandin E1 = H2O + prostaglandin A1"}
{"X":42265,"RHEA_ID":40578,"compounds":"glutaryl-CoA + H2O <=> CoA + glutarate + H(+)"}
{"X":42266,"RHEA_ID":43872,"compounds":"3-oxochol-4-en-22-oate + ATP + CoA = 3-oxochol-4-en-22-oyl-CoA + AMP + diphosphate"}
{"X":42267,"RHEA_ID":40580,"compounds":"1-O-(1Z)-hexadecenyl-2 (5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+)"}
{"X":42268,"RHEA_ID":50552,"compounds":"prostaglandin C1 = prostaglandin B1"}
{"X":42269,"RHEA_ID":40582,"compounds":"1-O-(1Z)-hexadecenyl-2 (5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+)"}
{"X":42270,"RHEA_ID":43876,"compounds":"3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oate + ATP + CoA = 3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oyl-CoA + AMP + diphosphate"}
{"X":42271,"RHEA_ID":40584,"compounds":"H2O + hexanedioyl-CoA => CoA + H(+) + hexanedioate"}
{"X":42272,"RHEA_ID":50556,"compounds":"prostaglandin D2 = H2O + prostaglandin J2"}
{"X":42273,"RHEA_ID":40586,"compounds":"H2O + hexanedioyl-CoA <=> CoA + H(+) + hexanedioate"}
{"X":42274,"RHEA_ID":43880,"compounds":"3beta-hydroxy-5-cholestenoate + ATP + CoA = 3beta-hydroxy-5-cholestenoyl-CoA + AMP + diphosphate"}
{"X":42275,"RHEA_ID":40588,"compounds":"H2O + octanedioyl-CoA => CoA + H(+) + octanedioate"}
{"X":42276,"RHEA_ID":50560,"DIRECTION":"UN","MASTER_ID":50560,"ec":"2.3.1.256","compounds":"acetyl-CoA + N-terminal L-methionyl-L-tryptophyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tryptophyl-[protein]"}
{"X":42277,"RHEA_ID":40590,"compounds":"H2O + octanedioyl-CoA <=> CoA + H(+) + octanedioate"}
{"X":42278,"RHEA_ID":60723,"compounds":"(E)-hept-2-enal + H2O + NADP(+) <=> (E)-hept-2-enoate + 2 H(+) + NADPH"}
{"X":42279,"RHEA_ID":40592,"compounds":"decanedioyl-CoA + H2O => CoA + decanedioate + H(+)"}
{"X":42280,"RHEA_ID":50564,"DIRECTION":"UN","MASTER_ID":50564,"ec":"2.3.1.258","compounds":"acetyl-CoA + N-terminal L-methionyl-L-alanyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-alanyl-[protein]"}
{"X":42281,"RHEA_ID":40594,"compounds":"decanedioyl-CoA + H2O <=> CoA + decanedioate + H(+)"}
{"X":42282,"RHEA_ID":60727,"compounds":"dodecanal + H2O + NADP(+) <=> dodecanoate + 2 H(+) + NADPH"}
{"X":42283,"RHEA_ID":40596,"compounds":"dodecanedioyl-CoA + H2O => CoA + dodecanedioate + H(+)"}
{"X":42284,"RHEA_ID":40597,"compounds":"CoA + dodecanedioate + H(+) => dodecanedioyl-CoA + H2O"}
{"X":42285,"RHEA_ID":50569,"DIRECTION":"LR","MASTER_ID":50568,"metacyc":"RXN-17870","compounds":"acetyl-CoA + N-terminal L-methionyl-L-seryl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-seryl-[protein]"}
{"X":42286,"RHEA_ID":60731,"compounds":"citral + H2O + NADP(+) <=> 3,7-dimethylocta-2,6-dienoate + 2 H(+) + NADPH"}
{"X":42287,"RHEA_ID":40600,"compounds":"1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + H2O => a 2-acyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate"}
{"X":42288,"RHEA_ID":40601,"compounds":"a 2-acyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + H2O"}
{"X":42289,"RHEA_ID":40602,"compounds":"1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> a 2-acyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate"}
{"X":42290,"RHEA_ID":43896,"compounds":"3beta-hydroxy-5alpha-androstan-17-one + O2 + reduced [NADPH--hemoprotein reductase] = 3beta,7alpha-dihydroxy-5alpha-androstan-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":42291,"RHEA_ID":40604,"compounds":"1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O => (9Z,12Z)-octadecadienoate + glycerol + H(+)"}
{"X":42292,"RHEA_ID":40605,"compounds":"(9Z,12Z)-octadecadienoate + glycerol + H(+) => 1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O"}
{"X":42293,"RHEA_ID":40606,"compounds":"1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O <=> (9Z,12Z)-octadecadienoate + glycerol + H(+)"}
{"X":42294,"RHEA_ID":50578,"compounds":"CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-threonyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-threonyl-[protein]"}
{"X":42295,"RHEA_ID":40608,"compounds":"1-tetradecanoyl-sn-glycerol + H2O => glycerol + H(+) + tetradecanoate"}
{"X":42296,"RHEA_ID":40609,"compounds":"glycerol + H(+) + tetradecanoate => 1-tetradecanoyl-sn-glycerol + H2O"}
{"X":42297,"RHEA_ID":40610,"compounds":"1-tetradecanoyl-sn-glycerol + H2O <=> glycerol + H(+) + tetradecanoate"}
{"X":42298,"RHEA_ID":43904,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol = all-trans-retinyl hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":42299,"RHEA_ID":40612,"compounds":"H2O + trihexanoylglycerol => 2,3-dihexanoyl-sn-glycerol + H(+) + hexanoate"}
{"X":42300,"RHEA_ID":40613,"compounds":"2,3-dihexanoyl-sn-glycerol + H(+) + hexanoate => H2O + trihexanoylglycerol"}
{"X":42301,"RHEA_ID":40614,"compounds":"H2O + trihexanoylglycerol <=> 2,3-dihexanoyl-sn-glycerol + H(+) + hexanoate"}
{"X":42302,"RHEA_ID":60747,"compounds":"(1R,3R)-chrysanthemoyl-CoA + (Z,S)-pyrethrolone <=> CoA + pyrethrin I"}
{"X":42303,"RHEA_ID":50587,"compounds":"13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) <=> 15-oxo-prostaglandin E1 + H(+) + NADPH"}
{"X":42304,"RHEA_ID":40617,"compounds":"2,3-didecanoyl-sn-glycerol + decanoate + H(+) => H2O + tridecanoylglycerol"}
{"X":42305,"RHEA_ID":40618,"compounds":"H2O + tridecanoylglycerol <=> 2,3-didecanoyl-sn-glycerol + decanoate + H(+)"}
{"X":42306,"RHEA_ID":60751,"compounds":"(1R,3R)-pyrethroyl-CoA + (Z,S)-pyrethrolone <=> CoA + pyrethrin II"}
{"X":42307,"RHEA_ID":50591,"compounds":"13,14-dihydro-15-oxo-PGF2alpha + NADP(+) <=> 15-oxo-prostaglandin F2alpha + H(+) + NADPH"}
{"X":42308,"RHEA_ID":40621,"compounds":"2,3-didodecanoyl-sn-glycerol + dodecanoate + H(+) => H2O + tridodecanoylglycerol"}
{"X":42309,"RHEA_ID":40622,"compounds":"H2O + tridodecanoylglycerol <=> 2,3-didodecanoyl-sn-glycerol + dodecanoate + H(+)"}
{"X":42310,"RHEA_ID":50594,"compounds":"15-oxoprostaglandin F1alpha + H(+) + NADPH => 13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+)"}
{"X":42311,"RHEA_ID":40624,"compounds":"H2O + tritetradecanoylglycerol => 2,3-ditetradecanoyl-sn-glycerol + H(+) + tetradecanoate"}
{"X":42312,"RHEA_ID":40625,"compounds":"2,3-ditetradecanoyl-sn-glycerol + H(+) + tetradecanoate => H2O + tritetradecanoylglycerol"}
{"X":42313,"RHEA_ID":40626,"compounds":"H2O + tritetradecanoylglycerol <=> 2,3-ditetradecanoyl-sn-glycerol + H(+) + tetradecanoate"}
{"X":42314,"RHEA_ID":60759,"compounds":"(1R,3R)-chrysanthemoyl-CoA + (Z,S)-cinerolone <=> cinerin I + CoA"}
{"X":42315,"RHEA_ID":40628,"compounds":"H2O + trihexadecanoylglycerol => 2,3-dihexadecanoyl-sn-glycerol + H(+) + hexadecanoate"}
{"X":42316,"RHEA_ID":40629,"compounds":"2,3-dihexadecanoyl-sn-glycerol + H(+) + hexadecanoate => H2O + trihexadecanoylglycerol"}
{"X":42317,"RHEA_ID":40630,"compounds":"H2O + trihexadecanoylglycerol <=> 2,3-dihexadecanoyl-sn-glycerol + H(+) + hexadecanoate"}
{"X":42318,"RHEA_ID":60763,"compounds":"(1R,3R)-pyrethroyl-CoA + (Z,S)-jasmololone <=> CoA + jasmolin II"}
{"X":42319,"RHEA_ID":50603,"compounds":"acetyl-CoA + N-terminal L-seryl-[histone H2A] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H2A]"}
{"X":42320,"RHEA_ID":40633,"compounds":"2,3-dioctadecanoyl-sn-glycerol + H(+) + octadecanoate => H2O + trioctadecanoylglycerol"}
{"X":42321,"RHEA_ID":40634,"compounds":"H2O + trioctadecanoylglycerol <=> 2,3-dioctadecanoyl-sn-glycerol + H(+) + octadecanoate"}
{"X":42322,"RHEA_ID":60767,"compounds":"(1R,3R)-pyrethroyl-CoA + (Z,S)-cinerolone <=> cinerin II + CoA"}
{"X":42323,"RHEA_ID":50607,"compounds":"acetyl-CoA + N-terminal L-methionyl-[transmembrane protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein]"}
{"X":42324,"RHEA_ID":40637,"compounds":"2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+) + hexadecanoate => 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O"}
{"X":42325,"RHEA_ID":40638,"compounds":"1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O <=> 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+) + hexadecanoate"}
{"X":42326,"RHEA_ID":43932,"DIRECTION":"UN","MASTER_ID":43932,"ec":"1.1.1.145","compounds":"3beta-hydroxyandrost-5-en-17-one + NAD(+) = androst-5-ene-3,17-dione + H(+) + NADH"}
{"X":42327,"RHEA_ID":50611,"compounds":"leukotriene B4 + NADP(+) <=> 12-oxo-leukotriene B4 + H(+) + NADPH"}
{"X":42328,"RHEA_ID":40641,"compounds":"(9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+) => 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H2O"}
{"X":42329,"RHEA_ID":40642,"compounds":"1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H2O <=> (9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+)"}
{"X":42330,"RHEA_ID":43936,"compounds":"androst-5-ene-3,17-dione = androst-4-ene-3,17-dione"}
{"X":42331,"RHEA_ID":50615,"compounds":"decanal + NADP(+) <=> (2E)-dec-2-enal + H(+) + NADPH"}
{"X":42332,"RHEA_ID":40645,"compounds":"(9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+) => 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":42333,"RHEA_ID":40646,"compounds":"1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":42334,"RHEA_ID":60787,"compounds":"2-oxoglutarate + gibberellin A24 + O2 <=> CO2 + gibberellin A25 + H(+) + succinate"}
{"X":42335,"RHEA_ID":50619,"compounds":"NADP(+) + nonan-2-one <=> (3E)-3-nonen-2-one + H(+) + NADPH"}
{"X":42336,"RHEA_ID":40649,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+) => 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H2O"}
{"X":42337,"RHEA_ID":40650,"compounds":"1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+)"}
{"X":42338,"RHEA_ID":50622,"compounds":"alpha-D-Gal-(1->3)-alpha-D-GlcNAc-diphospho-di-trans,octa-cis-undecaprenol + H(+) + UDP => N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UDP-alpha-D-galactose"}
{"X":42339,"RHEA_ID":50623,"DIRECTION":"BI","MASTER_ID":50620,"metacyc":"RXN-18119","compounds":"N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UDP-alpha-D-galactose <=> alpha-D-Gal-(1->3)-alpha-D-GlcNAc-diphospho-di-trans,octa-cis-undecaprenol + H(+) + UDP"}
{"X":42340,"RHEA_ID":40653,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+) => 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O"}
{"X":42341,"RHEA_ID":40654,"compounds":"1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":42342,"RHEA_ID":50626,"compounds":"a 2-(omega-methylsulfanyl)alkylmalate + CoA + H(+) => acetyl-CoA + an omega-(methylsulfanyl)-2-oxoalkanoate + H2O"}
{"X":42343,"RHEA_ID":60820,"compounds":"H2O + NADPH = adenosine 3',5'-bisphosphate + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide"}
{"X":42344,"RHEA_ID":40657,"compounds":"(R)-malyl-CoA + succinate => (R)-malate + succinyl-CoA"}
{"X":42345,"RHEA_ID":50629,"compounds":"a 2-(omega-methylsulfanyl)alkylmalate => a 3-(omega-methylsulfanyl)alkylmalate"}
{"X":42346,"RHEA_ID":40659,"compounds":"1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + H(+) + hexadecanoate"}
{"X":42347,"RHEA_ID":50631,"DIRECTION":"BI","MASTER_ID":50628,"metacyc":"RXN-18196","compounds":"a 2-(omega-methylsulfanyl)alkylmalate <=> a 3-(omega-methylsulfanyl)alkylmalate"}
{"X":42348,"RHEA_ID":40661,"compounds":"1-O-hexadecylglycerone 3-phosphate + H(+) + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol"}
{"X":42349,"RHEA_ID":40662,"compounds":"1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol <=> 1-O-hexadecylglycerone 3-phosphate + H(+) + hexadecanoate"}
{"X":42350,"RHEA_ID":40663,"compounds":"L-serine = 2-aminoprop-2-enoate + H2O"}
{"X":42351,"RHEA_ID":50635,"DIRECTION":"BI","MASTER_ID":50632,"metacyc":"RXN-18194","compounds":"a 2-(omega-methylsulfanyl)alkylmalate <=> a 2-(omega-methylsulfanyl)alkylmaleate + H2O"}
{"X":42352,"RHEA_ID":50636,"DIRECTION":"UN","MASTER_ID":50636,"ec":"4.2.1.170","compounds":"a 3-(omega-methylsulfanyl)alkylmalate = a 2-(omega-methylsulfanyl)alkylmaleate + H2O"}
{"X":42353,"RHEA_ID":40667,"compounds":"2-aminoprop-2-enoate = 2-iminopropanoate"}
{"X":42354,"RHEA_ID":40668,"DIRECTION":"LR","MASTER_ID":40667,"ecocyc":"RXN-15124","metacyc":"RXN-15124","compounds":"2-aminoprop-2-enoate => 2-iminopropanoate"}
{"X":42355,"RHEA_ID":40669,"compounds":"2-iminopropanoate => 2-aminoprop-2-enoate"}
{"X":42356,"RHEA_ID":50641,"DIRECTION":"LR","MASTER_ID":50640,"metacyc":"RXN-2203","compounds":"2-(2-methylsulfanyl)ethylmalate => 3-(2-methylsulfanyl)ethylmalate"}
{"X":42357,"RHEA_ID":60835,"compounds":"a 5'-end triphospho-guanosine in mRNA + H2O <=> a 5'-end diphospho-guanosine in mRNA + H(+) + phosphate"}
{"X":42358,"RHEA_ID":40672,"DIRECTION":"LR","MASTER_ID":40671,"ecocyc":"RXN-15127","metacyc":"RXN-15127","compounds":"2-iminopropanoate + H2O => NH4(+) + pyruvate"}
{"X":42359,"RHEA_ID":40673,"compounds":"NH4(+) + pyruvate => 2-iminopropanoate + H2O"}
{"X":42360,"RHEA_ID":40675,"compounds":"L-threonine = 2-aminobut-2-enoate + H2O"}
{"X":42361,"RHEA_ID":60840,"compounds":"a 5'-end diphospho-adenosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] = a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + L-lysyl-[protein]"}
{"X":42362,"RHEA_ID":40677,"compounds":"2-aminobut-2-enoate + H2O => L-threonine"}
{"X":42363,"RHEA_ID":40678,"compounds":"L-threonine <=> 2-aminobut-2-enoate + H2O"}
{"X":42364,"RHEA_ID":50650,"compounds":"2-(2-methylsulfanyl)ethylmaleate + H2O => 2-(2-methylsulfanyl)ethylmalate"}
{"X":42365,"RHEA_ID":50651,"DIRECTION":"BI","MASTER_ID":50648,"metacyc":"RXN-18182","compounds":"2-(2-methylsulfanyl)ethylmalate <=> 2-(2-methylsulfanyl)ethylmaleate + H2O"}
{"X":42366,"RHEA_ID":40681,"compounds":"1-O-(9Z)-octadecenylglycerone 3-phosphate + H(+) + hexadecanoate => (9Z)-octadecen-1-ol + 1-hexadecanoylglycerone 3-phosphate"}
{"X":42367,"RHEA_ID":40682,"compounds":"(9Z)-octadecen-1-ol + 1-hexadecanoylglycerone 3-phosphate <=> 1-O-(9Z)-octadecenylglycerone 3-phosphate + H(+) + hexadecanoate"}
{"X":42368,"RHEA_ID":60847,"compounds":"a 5'-end diphospho-guanosine in mRNA + GTP + H(+) <=> a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + diphosphate"}
{"X":42369,"RHEA_ID":40684,"compounds":"1-hexadecanoylglycerone 3-phosphate + dodecan-1-ol => 1-O-dodecylglycerone 3-phosphate + H(+) + hexadecanoate"}
{"X":42370,"RHEA_ID":40685,"compounds":"1-O-dodecylglycerone 3-phosphate + H(+) + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + dodecan-1-ol"}
{"X":42371,"RHEA_ID":40686,"compounds":"1-hexadecanoylglycerone 3-phosphate + dodecan-1-ol <=> 1-O-dodecylglycerone 3-phosphate + H(+) + hexadecanoate"}
{"X":42372,"RHEA_ID":60851,"compounds":"a 5'-end diphospho-guanosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] <=> a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + L-lysyl-[protein]"}
{"X":42373,"RHEA_ID":50659,"DIRECTION":"BI","MASTER_ID":50656,"metacyc":"RXN-18183","compounds":"3-(2-methylsulfanyl)ethylmalate <=> 2-(2-methylsulfanyl)ethylmaleate + H2O"}
{"X":42374,"RHEA_ID":40689,"compounds":"1-O-tetradecylglycerone 3-phosphate + H(+) + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + tetradecan-1-ol"}
{"X":42375,"RHEA_ID":40690,"compounds":"1-hexadecanoylglycerone 3-phosphate + tetradecan-1-ol <=> 1-O-tetradecylglycerone 3-phosphate + H(+) + hexadecanoate"}
{"X":42376,"RHEA_ID":50662,"compounds":"2-(2-methylsulfanyl)propylmaleate + H2O => 3-(3-methylsulfanyl)propylmalate"}
{"X":42377,"RHEA_ID":40692,"compounds":"1-hexadecanoylglycerone 3-phosphate + pentadecan-1-ol => 1-O-pentadecylglycerone 3-phosphate + H(+) + hexadecanoate"}
{"X":42378,"RHEA_ID":40693,"compounds":"1-O-pentadecylglycerone 3-phosphate + H(+) + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + pentadecan-1-ol"}
{"X":42379,"RHEA_ID":40694,"compounds":"1-hexadecanoylglycerone 3-phosphate + pentadecan-1-ol <=> 1-O-pentadecylglycerone 3-phosphate + H(+) + hexadecanoate"}
{"X":42380,"RHEA_ID":40695,"compounds":"1-hexadecanoylglycerone 3-phosphate + heptadecan-1-ol = 1-O-heptadecylglycerone 3-phosphate + H(+) + hexadecanoate"}
{"X":42381,"RHEA_ID":50667,"compounds":"a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose <=> an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GlcNAc derivative + GDP + H(+)"}
{"X":42382,"RHEA_ID":40697,"compounds":"1-O-heptadecylglycerone 3-phosphate + H(+) + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + heptadecan-1-ol"}
{"X":42383,"RHEA_ID":40698,"compounds":"1-hexadecanoylglycerone 3-phosphate + heptadecan-1-ol <=> 1-O-heptadecylglycerone 3-phosphate + H(+) + hexadecanoate"}
{"X":42384,"RHEA_ID":50670,"compounds":"an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP + H(+) => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose"}
{"X":42385,"RHEA_ID":60864,"DIRECTION":"UN","MASTER_ID":60864,"ec":"2.1.1.57","compounds":"a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-guanosine) in mRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":42386,"RHEA_ID":40701,"compounds":"1-O-octadecylglycerone 3-phosphate + H(+) + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + octadecan-1-ol"}
{"X":42387,"RHEA_ID":40702,"compounds":"1-hexadecanoylglycerone 3-phosphate + octadecan-1-ol <=> 1-O-octadecylglycerone 3-phosphate + H(+) + hexadecanoate"}
{"X":42388,"RHEA_ID":60867,"compounds":"a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-guanosine) in mRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":42389,"RHEA_ID":50675,"compounds":"[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + H2O <=> [(1->4)-N-acetyl-beta-D-glucosaminyl](n-2) + N,N'-diacetylchitobiose"}
{"X":42390,"RHEA_ID":40705,"compounds":"1-O-(9Z,12Z)-octadecadienylglycerone 3-phosphate + H(+) + hexadecanoate => (9Z,12Z)-octadecadien-1-ol + 1-hexadecanoylglycerone 3-phosphate"}
{"X":42391,"RHEA_ID":40706,"compounds":"(9Z,12Z)-octadecadien-1-ol + 1-hexadecanoylglycerone 3-phosphate <=> 1-O-(9Z,12Z)-octadecadienylglycerone 3-phosphate + H(+) + hexadecanoate"}
{"X":42392,"RHEA_ID":60871,"compounds":"a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O <=> a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(7)-methylguanosine 5'-diphosphate"}
{"X":42393,"RHEA_ID":40709,"compounds":"1-O-(9Z,12Z,15Z)-octadecatrienylglycerone 3-phosphate + H(+) + hexadecanoate => (9Z,12Z,15Z)-octadecatrien-1-ol + 1-hexadecanoylglycerone 3-phosphate"}
{"X":42394,"RHEA_ID":40710,"compounds":"(9Z,12Z,15Z)-octadecatrien-1-ol + 1-hexadecanoylglycerone 3-phosphate <=> 1-O-(9Z,12Z,15Z)-octadecatrienylglycerone 3-phosphate + H(+) + hexadecanoate"}
{"X":42395,"RHEA_ID":50682,"compounds":"N-terminal L-glutamyl-[protein] + NH4(+) => H2O + N-terminal L-glutaminyl-[protein]"}
{"X":42396,"RHEA_ID":40712,"compounds":"1-octadecanoylglycerone 3-phosphate + hexadecan-1-ol => 1-O-hexadecylglycerone 3-phosphate + H(+) + octadecanoate"}
{"X":42397,"RHEA_ID":40713,"compounds":"1-O-hexadecylglycerone 3-phosphate + H(+) + octadecanoate => 1-octadecanoylglycerone 3-phosphate + hexadecan-1-ol"}
{"X":42398,"RHEA_ID":40714,"compounds":"1-octadecanoylglycerone 3-phosphate + hexadecan-1-ol <=> 1-O-hexadecylglycerone 3-phosphate + H(+) + octadecanoate"}
{"X":42399,"RHEA_ID":50686,"compounds":"aniline + H(+) + L-glutamate => H2O + N(5)-phenyl-L-glutamine"}
{"X":42400,"RHEA_ID":44021,"compounds":"H2O + NAD(+) + octadecanal => 2 H(+) + NADH + octadecanoate"}
{"X":42401,"RHEA_ID":40717,"compounds":"1-hexadecanoylglycerone 3-phosphate + CoA => dihydroxyacetone phosphate + hexadecanoyl-CoA"}
{"X":42402,"RHEA_ID":40718,"compounds":"dihydroxyacetone phosphate + hexadecanoyl-CoA <=> 1-hexadecanoylglycerone 3-phosphate + CoA"}
{"X":42403,"RHEA_ID":50694,"compounds":"ADP + alpha-maltose 1-phosphate + H(+) => ADP-alpha-D-glucose + alpha-D-glucose 1-phosphate"}
{"X":42404,"RHEA_ID":50695,"compounds":"ADP-alpha-D-glucose + alpha-D-glucose 1-phosphate <=> ADP + alpha-maltose 1-phosphate + H(+)"}
{"X":42405,"RHEA_ID":40721,"compounds":"an S-substituted glutathione + cob(I)alamin--[alkylcobalamin reductase] + H(+) => an alkylcob(III)alamin + apo--[alkylcobalamin reductase] + glutathione"}
{"X":42406,"RHEA_ID":40722,"compounds":"an alkylcob(III)alamin + apo--[alkylcobalamin reductase] + glutathione <=> an S-substituted glutathione + cob(I)alamin--[alkylcobalamin reductase] + H(+)"}
{"X":42407,"RHEA_ID":40723,"compounds":"(9E)-octadecenoyl-CoA + H2O = (9E)-octadecenoate + CoA + H(+)"}
{"X":42408,"RHEA_ID":44029,"compounds":"L-altrarate => 5-dehydro-4-deoxy-D-glucarate + H2O"}
{"X":42409,"RHEA_ID":40725,"compounds":"(9E)-octadecenoate + CoA + H(+) => (9E)-octadecenoyl-CoA + H2O"}
{"X":42410,"RHEA_ID":40726,"compounds":"(9E)-octadecenoyl-CoA + H2O <=> (9E)-octadecenoate + CoA + H(+)"}
{"X":42411,"RHEA_ID":54011,"compounds":"(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O <=> (8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate"}
{"X":42412,"RHEA_ID":54012,"compounds":"(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = (8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate"}
{"X":42413,"RHEA_ID":40729,"compounds":"a 1-acylglycerone 3-phosphate + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + a long-chain fatty acid"}
{"X":42414,"RHEA_ID":40730,"compounds":"1-hexadecanoylglycerone 3-phosphate + a long-chain fatty acid <=> a 1-acylglycerone 3-phosphate + hexadecanoate"}
{"X":42415,"RHEA_ID":40731,"DIRECTION":"UN","MASTER_ID":40731,"ec":"3.2.1.191","compounds":"(20S)-ginsenoside Rg3 + 2 H2O = (20S)-protopanaxadiol + 2 D-glucose"}
{"X":42416,"RHEA_ID":54016,"compounds":"(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = (8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate"}
{"X":42417,"RHEA_ID":40733,"compounds":"(20S)-protopanaxadiol + 2 D-glucose => (20S)-ginsenoside Rg3 + 2 H2O"}
{"X":42418,"RHEA_ID":40734,"compounds":"(20S)-ginsenoside Rg3 + 2 H2O <=> (20S)-protopanaxadiol + 2 D-glucose"}
{"X":42419,"RHEA_ID":40735,"DIRECTION":"UN","MASTER_ID":40735,"ec":"3.2.1.191","compounds":"(20S)-ginsenoside Rb1 + 2 H2O = 2 D-glucose + gypenoside LXXV"}
{"X":42420,"RHEA_ID":54020,"compounds":"L-lysyl-[protein] + propanoyl-CoA = CoA + H(+) + N(6)-propanoyl-L-lysyl-[protein]"}
{"X":42421,"RHEA_ID":40737,"compounds":"2 D-glucose + gypenoside LXXV => (20S)-ginsenoside Rb1 + 2 H2O"}
{"X":42422,"RHEA_ID":40738,"compounds":"(20S)-ginsenoside Rb1 + 2 H2O <=> 2 D-glucose + gypenoside LXXV"}
{"X":42423,"RHEA_ID":40739,"DIRECTION":"UN","MASTER_ID":40739,"ec":"3.2.1.191","compounds":"(20S)-ginsenoside Rb2 + 2 H2O = (20S)-ginsenoside C-Y + 2 D-glucose"}
{"X":42424,"RHEA_ID":44045,"compounds":"11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O => 11,12-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate"}
{"X":42425,"RHEA_ID":40741,"compounds":"(20S)-ginsenoside C-Y + 2 D-glucose => (20S)-ginsenoside Rb2 + 2 H2O"}
{"X":42426,"RHEA_ID":40742,"compounds":"(20S)-ginsenoside Rb2 + 2 H2O <=> (20S)-ginsenoside C-Y + 2 D-glucose"}
{"X":42427,"RHEA_ID":40743,"DIRECTION":"UN","MASTER_ID":40743,"ec":"3.2.1.191","compounds":"(20S)-ginsenoside Rd + 2 H2O = (20S)-ginsenoside C-K + 2 D-glucose"}
{"X":42428,"RHEA_ID":60912,"compounds":"cytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-methionine = H(+) + N(3)-methylcytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-homocysteine"}
{"X":42429,"RHEA_ID":40745,"compounds":"(20S)-ginsenoside C-K + 2 D-glucose => (20S)-ginsenoside Rd + 2 H2O"}
{"X":42430,"RHEA_ID":40746,"compounds":"(20S)-ginsenoside Rd + 2 H2O <=> (20S)-ginsenoside C-K + 2 D-glucose"}
{"X":42431,"RHEA_ID":40747,"compounds":"2-oxoglutarate + L-lysine + O2 = (3S)-3-hydroxy-L-lysine + CO2 + succinate"}
{"X":42432,"RHEA_ID":54032,"compounds":"(6S)-10-formyltetrahydrofolate + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose = (6S)-5,6,7,8-tetrahydrofolate + dTDP-4-formamido-4,6-dideoxy-alpha-D-glucose + H(+)"}
{"X":42433,"RHEA_ID":40749,"compounds":"(3S)-3-hydroxy-L-lysine + CO2 + succinate => 2-oxoglutarate + L-lysine + O2"}
{"X":42434,"RHEA_ID":40750,"compounds":"2-oxoglutarate + L-lysine + O2 <=> (3S)-3-hydroxy-L-lysine + CO2 + succinate"}
{"X":42435,"RHEA_ID":40751,"compounds":"(9Z)-octadecenoate + 1-hexadecanoylglycerone 3-phosphate = 1-(9Z)-octadecenoylglycerone 3-phosphate + hexadecanoate"}
{"X":42436,"RHEA_ID":54036,"DIRECTION":"UN","MASTER_ID":54036,"ec":"1.20.4.3","compounds":"[mycoredoxin]-L-cysteine + arseno-mycothiol + H(+) = [mycoredoxin]-S-mycothiol-L-cysteine + arsenite"}
{"X":42437,"RHEA_ID":50728,"compounds":"(Z)-(4-hydroxyphenyl)acetaldehyde oxime = 4-hydroxyphenylacetonitrile + H2O"}
{"X":42438,"RHEA_ID":40754,"compounds":"(9Z)-octadecenoate + 1-hexadecanoylglycerone 3-phosphate <=> 1-(9Z)-octadecenoylglycerone 3-phosphate + hexadecanoate"}
{"X":42439,"RHEA_ID":40755,"compounds":"(9Z,12Z)-octadecadienoate + 1-hexadecanoylglycerone 3-phosphate = 1-(9Z,12Z)-octadecadienoylglycerone 3-phosphate + hexadecanoate"}
{"X":42440,"RHEA_ID":54040,"DIRECTION":"UN","MASTER_ID":54040,"ec":"4.2.3.168","compounds":"all-trans-geranylgeranyl diphosphate = (3E,7E)-dolathalia-3,7,11-triene + diphosphate"}
{"X":42441,"RHEA_ID":50732,"compounds":"4-hydroxyphenylacetonitrile + O2 + reduced [NADPH--hemoprotein reductase] = (S)-4-hydroxymandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":42442,"RHEA_ID":40758,"compounds":"(9Z,12Z)-octadecadienoate + 1-hexadecanoylglycerone 3-phosphate <=> 1-(9Z,12Z)-octadecadienoylglycerone 3-phosphate + hexadecanoate"}
{"X":42443,"RHEA_ID":40759,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoylglycerone 3-phosphate = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerone 3-phosphate + hexadecanoate"}
{"X":42444,"RHEA_ID":54044,"DIRECTION":"UN","MASTER_ID":54044,"ec":"4.2.3.169","compounds":"(2E,6E)-farnesyl diphosphate + H2O = 7-epi-alpha-eudesmol + diphosphate"}
{"X":42445,"RHEA_ID":40761,"compounds":"1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerone 3-phosphate + hexadecanoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoylglycerone 3-phosphate"}
{"X":42446,"RHEA_ID":44067,"compounds":"hexadecanoyl-CoA + octan-1-ol <=> CoA + octyl hexadecanoyl"}
{"X":42447,"RHEA_ID":40763,"DIRECTION":"UN","MASTER_ID":40763,"ec":"3.2.1.194","compounds":"(20S)-ginsenoside Re + H2O = (20S)-ginsenoside Rg1 + L-rhamnopyranose"}
{"X":42448,"RHEA_ID":50739,"DIRECTION":"BI","MASTER_ID":50736,"metacyc":"RXN-18002","compounds":"a quinone + 2 H(+) + hydrogen sulfide + sulfite <=> a quinol + thiosulfate"}
{"X":42449,"RHEA_ID":50740,"compounds":"H2O + leukotriene C4 = glycine + leukotriene F4"}
{"X":42450,"RHEA_ID":40766,"DIRECTION":"BI","MASTER_ID":40763,"metacyc":"RXN-14583","compounds":"(20S)-ginsenoside Re + H2O <=> (20S)-ginsenoside Rg1 + L-rhamnopyranose"}
{"X":42451,"RHEA_ID":40767,"DIRECTION":"UN","MASTER_ID":40767,"ec":"3.2.1.194","compounds":"(20S)-ginsenoside R1 + H2O = (20S)-ginsenoside Rg1 + D-xylose"}
{"X":42452,"RHEA_ID":60936,"compounds":"an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an (omega-1)-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":42453,"RHEA_ID":50744,"DIRECTION":"UN","MASTER_ID":50744,"ec":"1.5.3.23","compounds":"2 glyphosate + O2 = 2 aminomethylphosphonate + 2 glyoxylate + 2 H(+)"}
{"X":42454,"RHEA_ID":40770,"DIRECTION":"BI","MASTER_ID":40767,"metacyc":"RXN-14581","compounds":"(20S)-ginsenoside R1 + H2O <=> (20S)-ginsenoside Rg1 + D-xylose"}
{"X":42455,"RHEA_ID":40771,"DIRECTION":"UN","MASTER_ID":40771,"ec":"3.2.1.194","compounds":"(20S)-ginsenoside Rg1 + H2O = (20S)-ginsenoside F1 + D-glucose"}
{"X":42456,"RHEA_ID":44077,"compounds":"ATP + CoA + pentadecanoate => AMP + diphosphate + pentadecanoyl-CoA"}
{"X":42457,"RHEA_ID":40773,"compounds":"(20S)-ginsenoside F1 + D-glucose => (20S)-ginsenoside Rg1 + H2O"}
{"X":42458,"RHEA_ID":50749,"DIRECTION":"LR","MASTER_ID":50748,"metacyc":"RXN-18102","compounds":"H2O + juglone => naphthalene-1,2,4,8-tetrol"}
{"X":42459,"RHEA_ID":40775,"compounds":"2-amino-2-phenylacetonitrile + H(+) + 2 H2O = D-alpha-phenylglycine + NH4(+)"}
{"X":42460,"RHEA_ID":60944,"compounds":"quercetin + S-adenosyl-L-methionine = H(+) + isorhamnetin + S-adenosyl-L-homocysteine"}
{"X":42461,"RHEA_ID":40777,"compounds":"D-alpha-phenylglycine + NH4(+) => 2-amino-2-phenylacetonitrile + H(+) + 2 H2O"}
{"X":42462,"RHEA_ID":44083,"compounds":"ATP + CoA + undecanoate <=> AMP + diphosphate + undecanoyl-CoA"}
{"X":42463,"RHEA_ID":40779,"compounds":"2-aminopentanenitrile + H(+) + 2 H2O = L-2-aminopentanoate + NH4(+)"}
{"X":42464,"RHEA_ID":44085,"compounds":"ATP + CoA + heptadecanoate => AMP + diphosphate + heptadecanoyl-CoA"}
{"X":42465,"RHEA_ID":44086,"compounds":"AMP + diphosphate + heptadecanoyl-CoA => ATP + CoA + heptadecanoate"}
{"X":42466,"RHEA_ID":44087,"compounds":"ATP + CoA + heptadecanoate <=> AMP + diphosphate + heptadecanoyl-CoA"}
{"X":42467,"RHEA_ID":40783,"compounds":"docosanoyl-CoA + H2O = CoA + docosanoate + H(+)"}
{"X":42468,"RHEA_ID":60952,"compounds":"(E)-5-hydroxyferulate + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + trans-sinapate"}
{"X":42469,"RHEA_ID":40785,"compounds":"CoA + docosanoate + H(+) => docosanoyl-CoA + H2O"}
{"X":42470,"RHEA_ID":44091,"compounds":"ATP + CoA + heptanoate <=> AMP + diphosphate + heptanoyl-CoA"}
{"X":42471,"RHEA_ID":40787,"compounds":"H2O + tetracosanoyl-CoA = CoA + H(+) + tetracosanoate"}
{"X":42472,"RHEA_ID":44094,"compounds":"AMP + diphosphate + nonadecanoyl-CoA => ATP + CoA + nonadecanoate"}
{"X":42473,"RHEA_ID":44095,"compounds":"ATP + CoA + nonadecanoate <=> AMP + diphosphate + nonadecanoyl-CoA"}
{"X":42474,"RHEA_ID":40791,"compounds":"H2O + hexacosanoyl-CoA = CoA + H(+) + hexacosanoate"}
{"X":42475,"RHEA_ID":54076,"DIRECTION":"UN","MASTER_ID":54076,"ec":"4.2.3.178","compounds":"(2E,6E,10E,14E)-geranylfarnesyl diphosphate = diphosphate + stellata-2,6,19-triene"}
{"X":42476,"RHEA_ID":44098,"compounds":"CoA + decanyl hexadecanoate => decan-1-ol + hexadecanoyl-CoA"}
{"X":42477,"RHEA_ID":50769,"DIRECTION":"LR","MASTER_ID":50768,"metacyc":"RXN-17978","compounds":"4-methylamino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine => anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine"}
{"X":42478,"RHEA_ID":40795,"compounds":"1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine"}
{"X":42479,"RHEA_ID":60964,"compounds":"(9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + UDP-alpha-D-glucose = (9Z)-17-hydroxyoctadec-9-enoate 17-O-sophoroside + H(+) + UDP"}
{"X":42480,"RHEA_ID":40797,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine => 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + L-serine"}
{"X":42481,"RHEA_ID":40798,"compounds":"1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine"}
{"X":42482,"RHEA_ID":40799,"compounds":"2-methylpropanoyl-CoA + H2O = 2-methylpropanoate + CoA + H(+)"}
{"X":42483,"RHEA_ID":40801,"compounds":"2-methylpropanoate + CoA + H(+) => 2-methylpropanoyl-CoA + H2O"}
{"X":42484,"RHEA_ID":50777,"compounds":"hexanal + NADP(+) => (E)-2-hexenal + H(+) + NADPH"}
{"X":42485,"RHEA_ID":40803,"DIRECTION":"UN","MASTER_ID":40803,"ec":"1.2.1.92","compounds":"3,6-anhydro-alpha-L-galactopyranose + H2O + NADP(+) = 3,6-anhydro-L-galactonate + 2 H(+) + NADPH"}
{"X":42486,"RHEA_ID":60976,"compounds":"(E)-4-hydroxynon-2-en-1-ol + NAD(+) = (E)-4-hydroxynon-2-enal + H(+) + NADH"}
{"X":42487,"RHEA_ID":40805,"compounds":"3,6-anhydro-L-galactonate + 2 H(+) + NADPH => 3,6-anhydro-alpha-L-galactopyranose + H2O + NADP(+)"}
{"X":42488,"RHEA_ID":60978,"compounds":"(E)-4-hydroxynon-2-enal + H(+) + NADH => (E)-4-hydroxynon-2-en-1-ol + NAD(+)"}
{"X":42489,"RHEA_ID":40807,"compounds":"a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + H(+) + sn-glycerol 3-phosphocholine"}
{"X":42490,"RHEA_ID":60980,"compounds":"12-hydroxydodecanoate + NAD(+) = 12-oxododecanoate + H(+) + NADH"}
{"X":42491,"RHEA_ID":40809,"compounds":"(9Z)-octadecenoate + H(+) + sn-glycerol 3-phosphocholine => a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O"}
{"X":42492,"RHEA_ID":50785,"compounds":"dodecanal + NADP(+) => (2E)-dodecenal + H(+) + NADPH"}
{"X":42493,"RHEA_ID":40811,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":42494,"RHEA_ID":60984,"compounds":"16-hydroxyhexadecanoate + NAD(+) = 16-oxohexadecanoate + H(+) + NADH"}
{"X":42495,"RHEA_ID":40813,"compounds":"(9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O"}
{"X":42496,"RHEA_ID":50789,"compounds":"NADP(+) + pentan-2-one => 2-oxo-(3E)-pentene + H(+) + NADPH"}
{"X":42497,"RHEA_ID":40815,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)"}
{"X":42498,"RHEA_ID":60988,"compounds":"(E)-hex-2-en-1-ol + NAD(+) = (E)-2-hexenal + H(+) + NADH"}
{"X":42499,"RHEA_ID":40817,"compounds":"(9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O"}
{"X":42500,"RHEA_ID":50793,"compounds":"18-hydroxycorticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] => aldosterone + 2 H2O + 2 oxidized [adrenodoxin]"}
{"X":42501,"RHEA_ID":40819,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":42502,"RHEA_ID":60996,"compounds":"H2O + L-leucine + O2 = 4-methyl-2-oxopentanoate + H2O2 + NH4(+)"}
{"X":42503,"RHEA_ID":40821,"compounds":"(9Z)-octadecenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O"}
{"X":42504,"RHEA_ID":50797,"compounds":"glutathione + prostaglandin A2 => prostaglandin A2-S-(R)-glutathione"}
{"X":42505,"RHEA_ID":44128,"compounds":"(9E)-octadecenoyl-CoA + hexadecan-1-ol = CoA + hexadecanyl (9E)-octadecenoate"}
{"X":42506,"RHEA_ID":61020,"compounds":"acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA = 5'-deoxyadenosine + carboxymethyluridine(34) in tRNA + CoA + 2 H(+) + L-methionine"}
{"X":42507,"RHEA_ID":40825,"compounds":"2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O"}
{"X":42508,"RHEA_ID":40826,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate"}
{"X":42509,"RHEA_ID":40827,"compounds":"2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine"}
{"X":42510,"RHEA_ID":50803,"compounds":"glutathione + prostaglandin A2 <=> prostaglandin A2-S-(S)-glutathione"}
{"X":42511,"RHEA_ID":40829,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":42512,"RHEA_ID":50805,"compounds":"glutathione + prostaglandin J2 => prostaglandin J2-S-(R)-glutathione"}
{"X":42513,"RHEA_ID":44136,"compounds":"dodecanoyl-CoA + hexadecan-1-ol = CoA + hexadecanyl dodecanoate"}
{"X":42514,"RHEA_ID":40832,"compounds":"1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine"}
{"X":42515,"RHEA_ID":40833,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O"}
{"X":42516,"RHEA_ID":40834,"compounds":"1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine"}
{"X":42517,"RHEA_ID":40835,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2 H2O = 2 (9Z)-octadecenoate + 2 H(+) + sn-glycerol 3-phosphocholine"}
{"X":42518,"RHEA_ID":50811,"compounds":"glutathione + prostaglandin J2 <=> prostaglandin J2-S-(S)-glutathione"}
{"X":42519,"RHEA_ID":40837,"compounds":"2 (9Z)-octadecenoate + 2 H(+) + sn-glycerol 3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2 H2O"}
{"X":42520,"RHEA_ID":61042,"compounds":"(+)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":42521,"RHEA_ID":44144,"compounds":"acetyl-CoA + L-methionine = CoA + H(+) + N(alpha)-acetyl-L-methionine"}
{"X":42522,"RHEA_ID":50815,"DIRECTION":"BI","MASTER_ID":50812,"metacyc":"RXN-17521","compounds":"androst-4-ene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 1alpha-hydroxyandrost-4-ene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":42523,"RHEA_ID":40841,"compounds":"(2E)-nonenoyl-CoA + FADH2 => FAD + H(+) + nonanoyl-CoA"}
{"X":42524,"RHEA_ID":50817,"compounds":"androst-4-ene-3,17-dione + H(+) + NADPH => 5alpha-androstan-3,17-dione + NADP(+)"}
{"X":42525,"RHEA_ID":44148,"compounds":"L-lysine = D-beta-lysine"}
{"X":42526,"RHEA_ID":50819,"compounds":"androst-4-ene-3,17-dione + H(+) + NADPH <=> 5alpha-androstan-3,17-dione + NADP(+)"}
{"X":42527,"RHEA_ID":40845,"compounds":"(2E)-octadecenoyl-CoA + FADH2 => FAD + H(+) + octadecanoyl-CoA"}
{"X":42528,"RHEA_ID":50821,"compounds":"17beta-hydroxy-5alpha-androstan-3-one + NADP(+) => H(+) + NADPH + testosterone"}
{"X":42529,"RHEA_ID":40847,"compounds":"eicosanoyl-CoA + FAD + H(+) = (2E)-eicosenoyl-CoA + FADH2"}
{"X":42530,"RHEA_ID":40848,"compounds":"eicosanoyl-CoA + FAD + H(+) => (2E)-eicosenoyl-CoA + FADH2"}
{"X":42531,"RHEA_ID":50824,"compounds":"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 = 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z)-docosapentaenoate"}
{"X":42532,"RHEA_ID":50825,"compounds":"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 => 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z)-docosapentaenoate"}
{"X":42533,"RHEA_ID":40851,"compounds":"FAD + H(+) + pentadecanoyl-CoA = (2E)-pentadecenoyl-CoA + FADH2"}
{"X":42534,"RHEA_ID":50827,"compounds":"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 <=> 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z)-docosapentaenoate"}
{"X":42535,"RHEA_ID":50828,"compounds":"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 = (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E)-docosapentaenoate"}
{"X":42536,"RHEA_ID":50829,"compounds":"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 => (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E)-docosapentaenoate"}
{"X":42537,"RHEA_ID":44160,"DIRECTION":"UN","MASTER_ID":44160,"ec":"3.1.3.25","compounds":"1D-myo-inositol 6-phosphate + H2O = myo-inositol + phosphate"}
{"X":42538,"RHEA_ID":50831,"compounds":"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 <=> (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E)-docosapentaenoate"}
{"X":42539,"RHEA_ID":50832,"compounds":"(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 = 17-hydroperoxy-(7Z,10Z,13Z,15E,19Z)-docosapentaenoate"}
{"X":42540,"RHEA_ID":50833,"DIRECTION":"LR","MASTER_ID":50832,"reactome":"R-HSA-9027607.2","compounds":"(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 => 17-hydroperoxy-(7Z,10Z,13Z,15E,19Z)-docosapentaenoate"}
{"X":42541,"RHEA_ID":40859,"compounds":"(9Z)-hexadecenoyl-CoA + FAD + H(+) = (2E,9Z)-hexadecadienoyl-CoA + FADH2"}
{"X":42542,"RHEA_ID":50835,"compounds":"(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 <=> 17-hydroperoxy-(7Z,10Z,13Z,15E,19Z)-docosapentaenoate"}
{"X":42543,"RHEA_ID":50836,"compounds":"(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 = 14-hydroperoxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoate"}
{"X":42544,"RHEA_ID":40862,"compounds":"(9Z)-hexadecenoyl-CoA + FAD + H(+) <=> (2E,9Z)-hexadecadienoyl-CoA + FADH2"}
{"X":42545,"RHEA_ID":40863,"compounds":"FAD + H(+) + heptadecanoyl-CoA = FADH2 + trans-2-heptadecenoyl-CoA"}
{"X":42546,"RHEA_ID":40864,"compounds":"FAD + H(+) + heptadecanoyl-CoA => FADH2 + trans-2-heptadecenoyl-CoA"}
{"X":42547,"RHEA_ID":40865,"compounds":"FADH2 + trans-2-heptadecenoyl-CoA => FAD + H(+) + heptadecanoyl-CoA"}
{"X":42548,"RHEA_ID":50841,"DIRECTION":"LR","MASTER_ID":50840,"reactome":"R-HSA-9020275.1","compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate"}
{"X":42549,"RHEA_ID":40867,"compounds":"(9E)-octadecenoyl-CoA + FAD + H(+) = (2E,9E)-octadecadienoyl-CoA + FADH2"}
{"X":42550,"RHEA_ID":50843,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate"}
{"X":42551,"RHEA_ID":50844,"compounds":"(5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate = (5S,6S)-epoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O"}
{"X":42552,"RHEA_ID":50845,"compounds":"(5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate => (5S,6S)-epoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O"}
{"X":42553,"RHEA_ID":40871,"compounds":"(9Z)-octadecenoyl-CoA + FAD + H(+) = (2E,9Z)-octadecadienoyl-CoA + FADH2"}
{"X":42554,"RHEA_ID":50847,"compounds":"(5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate <=> (5S,6S)-epoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O"}
{"X":42555,"RHEA_ID":40873,"compounds":"(2E,9Z)-octadecadienoyl-CoA + FADH2 => (9Z)-octadecenoyl-CoA + FAD + H(+)"}
{"X":42556,"RHEA_ID":50849,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 => (11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoate + A + H2O"}
{"X":42557,"RHEA_ID":40875,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + FAD + H(+) = (2E,9Z,12Z)-octadecatrienoyl-CoA + FADH2"}
{"X":42558,"RHEA_ID":50851,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 <=> (11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoate + A + H2O"}
{"X":42559,"RHEA_ID":40877,"compounds":"(2E,9Z,12Z)-octadecatrienoyl-CoA + FADH2 => (9Z,12Z)-octadecadienoyl-CoA + FAD + H(+)"}
{"X":42560,"RHEA_ID":50853,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 => (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O"}
{"X":42561,"RHEA_ID":40879,"compounds":"2 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine"}
{"X":42562,"RHEA_ID":40880,"compounds":"2 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine"}
{"X":42563,"RHEA_ID":50856,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O"}
{"X":42564,"RHEA_ID":50857,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 => (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O"}
{"X":42565,"RHEA_ID":40883,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + FAD + H(+) = (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + FADH2"}
{"X":42566,"RHEA_ID":40884,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + FAD + H(+) => (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + FADH2"}
{"X":42567,"RHEA_ID":50860,"compounds":"(9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O"}
{"X":42568,"RHEA_ID":50861,"compounds":"(9Z,12Z)-octadecadienoate + AH2 + O2 => 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O"}
{"X":42569,"RHEA_ID":40887,"compounds":"1-octadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + octadecanoate + sn-glycerol 3-phosphocholine"}
{"X":42570,"RHEA_ID":50863,"compounds":"(9Z,12Z)-octadecadienoate + AH2 + O2 <=> 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O"}
{"X":42571,"RHEA_ID":40889,"compounds":"H(+) + octadecanoate + sn-glycerol 3-phosphocholine => 1-octadecanoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":42572,"RHEA_ID":50865,"compounds":"(9Z,12Z)-octadecadienoate + AH2 + O2 => 9-hydroxy-(10E,12Z)-octadecadienoate + A + H2O"}
{"X":42573,"RHEA_ID":40891,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O = H(+) + hexadecanoate + sn-glycero-3-phosphoethanolamine"}
{"X":42574,"RHEA_ID":50867,"compounds":"(9Z,12Z)-octadecadienoate + AH2 + O2 <=> 9-hydroxy-(10E,12Z)-octadecadienoate + A + H2O"}
{"X":42575,"RHEA_ID":50868,"compounds":"(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 = (5,12,18R)-trihydroxy-(6Z,8E,10E,14Z,16E)-eicosapentaenoate"}
{"X":42576,"RHEA_ID":50869,"compounds":"(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 => (5,12,18R)-trihydroxy-(6Z,8E,10E,14Z,16E)-eicosapentaenoate"}
{"X":42577,"RHEA_ID":40895,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (9Z)-octadecenoate + H(+) + sn-glycero-3-phosphoethanolamine"}
{"X":42578,"RHEA_ID":40896,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O => (9Z)-octadecenoate + H(+) + sn-glycero-3-phosphoethanolamine"}
{"X":42579,"RHEA_ID":50872,"compounds":"(15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + O2 = (5,6,15R)-trihydroxy-(7E,9E,11Z,13E,17Z)-eicosapentaenoate"}
{"X":42580,"RHEA_ID":50873,"compounds":"(15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + O2 => (5,6,15R)-trihydroxy-(7E,9E,11Z,13E,17Z)-eicosapentaenoate"}
{"X":42581,"RHEA_ID":40899,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine"}
{"X":42582,"RHEA_ID":50875,"compounds":"(15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + O2 <=> (5,6,15R)-trihydroxy-(7E,9E,11Z,13E,17Z)-eicosapentaenoate"}
{"X":42583,"RHEA_ID":50876,"DIRECTION":"UN","MASTER_ID":50876,"ec":"1.11.1.22","compounds":"a hydroperoxy-polyunsaturated fatty acid + H(+) + NADPH = a hydroxy-polyunsaturated fatty acid + H2O + NADP(+)"}
{"X":42584,"RHEA_ID":50877,"DIRECTION":"LR","MASTER_ID":50876,"metacyc":"RXN-13944","compounds":"a hydroperoxy-polyunsaturated fatty acid + H(+) + NADPH => a hydroxy-polyunsaturated fatty acid + H2O + NADP(+)"}
{"X":42585,"RHEA_ID":40903,"compounds":"2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine"}
{"X":42586,"RHEA_ID":50879,"compounds":"a hydroperoxy-polyunsaturated fatty acid + H(+) + NADPH <=> a hydroxy-polyunsaturated fatty acid + H2O + NADP(+)"}
{"X":42587,"RHEA_ID":50880,"DIRECTION":"UN","MASTER_ID":50880,"ec":"2.7.8.45","compounds":"4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-glycerol = 4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)"}
{"X":42588,"RHEA_ID":50881,"DIRECTION":"LR","MASTER_ID":50880,"metacyc":"RXN-18006","compounds":"4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-glycerol => 4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)"}
{"X":42589,"RHEA_ID":40907,"compounds":"2 2-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine"}
{"X":42590,"RHEA_ID":61120,"compounds":"kaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 2 H(+) + 2 H2O + myricetin + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":42591,"RHEA_ID":50884,"compounds":"(9Z)-octadecenoyl-sn-glycero-3-phosphate + H2O = (9Z-octadecenoyl)-glycerol + phosphate"}
{"X":42592,"RHEA_ID":50885,"compounds":"(9Z)-octadecenoyl-sn-glycero-3-phosphate + H2O => (9Z-octadecenoyl)-glycerol + phosphate"}
{"X":42593,"RHEA_ID":40911,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)"}
{"X":42594,"RHEA_ID":50887,"compounds":"(9Z)-octadecenoyl-sn-glycero-3-phosphate + H2O <=> (9Z-octadecenoyl)-glycerol + phosphate"}
{"X":42595,"RHEA_ID":50888,"compounds":"an N-acylsphingoid base 1-phosphate + H2O = N-acyl-sphingoid base + phosphate"}
{"X":42596,"RHEA_ID":50889,"compounds":"an N-acylsphingoid base 1-phosphate + H2O => N-acyl-sphingoid base + phosphate"}
{"X":42597,"RHEA_ID":40915,"compounds":"1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":42598,"RHEA_ID":50891,"compounds":"an N-acylsphingoid base 1-phosphate + H2O <=> N-acyl-sphingoid base + phosphate"}
{"X":42599,"RHEA_ID":44222,"compounds":"15-hydroxypentadecanoyl-CoA + AMP + diphosphate => 15-hydroxypentadecanoate + ATP + CoA"}
{"X":42600,"RHEA_ID":50893,"DIRECTION":"LR","MASTER_ID":50892,"metacyc":"RXN-18001","compounds":"a menaquinone + 2 H(+) + hydrogen sulfide + sulfite => a menaquinol + thiosulfate"}
{"X":42601,"RHEA_ID":40919,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+)"}
{"X":42602,"RHEA_ID":50895,"compounds":"a menaquinone + 2 H(+) + hydrogen sulfide + sulfite <=> a menaquinol + thiosulfate"}
{"X":42603,"RHEA_ID":50896,"compounds":"8-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate + H2O = (8,11R,12S)-trihydroxy-(5Z,9E,14Z)-eicosatrienoate"}
{"X":42604,"RHEA_ID":50897,"compounds":"8-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate + H2O => (8,11R,12S)-trihydroxy-(5Z,9E,14Z)-eicosatrienoate"}
{"X":42605,"RHEA_ID":40923,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)"}
{"X":42606,"RHEA_ID":50899,"compounds":"8-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate + H2O <=> (8,11R,12S)-trihydroxy-(5Z,9E,14Z)-eicosatrienoate"}
{"X":42607,"RHEA_ID":50900,"compounds":"10-hydroxy-(11S,12S)-epoxy- (5Z,8Z,14Z)-eicosatrienoate + H2O = (10,11S,12R)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoate"}
{"X":42608,"RHEA_ID":50901,"compounds":"10-hydroxy-(11S,12S)-epoxy- (5Z,8Z,14Z)-eicosatrienoate + H2O => (10,11S,12R)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoate"}
{"X":42609,"RHEA_ID":40927,"compounds":"1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + H2O = (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycerol + H(+)"}
{"X":42610,"RHEA_ID":50903,"compounds":"10-hydroxy-(11S,12S)-epoxy- (5Z,8Z,14Z)-eicosatrienoate + H2O <=> (10,11S,12R)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoate"}
{"X":42611,"RHEA_ID":40929,"compounds":"(9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycerol + H(+) => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + H2O"}
{"X":42612,"RHEA_ID":50905,"compounds":"L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine => H(+) + N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine"}
{"X":42613,"RHEA_ID":40931,"compounds":"2-oxoglutarate + L-ornithine + O2 = (3S)-3-hydroxy-L-ornithine + CO2 + succinate"}
{"X":42614,"RHEA_ID":50907,"compounds":"L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine <=> H(+) + N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine"}
{"X":42615,"RHEA_ID":50908,"DIRECTION":"UN","MASTER_ID":50908,"ec":"1.14.99.60","compounds":"a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 = A + a 3-demethylubiquinol + H2O"}
{"X":42616,"RHEA_ID":50909,"DIRECTION":"LR","MASTER_ID":50908,"metacyc":"RXN-18458","compounds":"a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 => A + a 3-demethylubiquinol + H2O"}
{"X":42617,"RHEA_ID":40935,"compounds":"a 1-acylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + a fatty acid + H(+)"}
{"X":42618,"RHEA_ID":50912,"DIRECTION":"UN","MASTER_ID":50912,"ec":"2.7.8.46","compounds":"4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-L-ribitol = 4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)"}
{"X":42619,"RHEA_ID":40938,"compounds":"a 1-acylglycerone 3-phosphate + hexadecan-1-ol <=> 1-O-hexadecylglycerone 3-phosphate + a fatty acid + H(+)"}
{"X":42620,"RHEA_ID":40939,"compounds":"1-O-hexadecylglycerone 3-phosphate + H(+) + NADPH = 1-O-hexadecyl-sn-glycero-3-phosphate + NADP(+)"}
{"X":42621,"RHEA_ID":61152,"compounds":"(E)-caffeoyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] = CoA + myricetin 3-O-[(6-O-(E)-caffeoyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]"}
{"X":42622,"RHEA_ID":50916,"compounds":"a carboxylate + ATP + H(+) + NADPH = AMP + an aldehyde + diphosphate + NADP(+)"}
{"X":42623,"RHEA_ID":50917,"compounds":"a carboxylate + ATP + H(+) + NADPH => AMP + an aldehyde + diphosphate + NADP(+)"}
{"X":42624,"RHEA_ID":40943,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + hexadecanoate"}
{"X":42625,"RHEA_ID":50919,"compounds":"a carboxylate + ATP + H(+) + NADPH <=> AMP + an aldehyde + diphosphate + NADP(+)"}
{"X":42626,"RHEA_ID":50920,"DIRECTION":"UN","MASTER_ID":50920,"ec":"1.21.98.2","compounds":"2 2-iminio-3-(indol-3-yl)propanoate + H2O2 = chromopyrrolate + H(+) + 2 H2O + NH4(+)"}
{"X":42627,"RHEA_ID":40946,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + hexadecanoate"}
{"X":42628,"RHEA_ID":40951,"DIRECTION":"UN","MASTER_ID":40951,"ec":"3.5.1.125","compounds":"(2S)-2-acetamido-4-aminobutanoate + H2O = acetate + L-2,4-diaminobutanoate"}
{"X":42629,"RHEA_ID":50923,"compounds":"2 2-iminio-3-(indol-3-yl)propanoate + H2O2 <=> chromopyrrolate + H(+) + 2 H2O + NH4(+)"}
{"X":42630,"RHEA_ID":61161,"DIRECTION":"LR","MASTER_ID":61160,"metacyc":"RXN-8267","compounds":"quercetin + UDP-beta-L-rhamnose => H(+) + quercitrin + UDP"}
{"X":42631,"RHEA_ID":50925,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 => (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate"}
{"X":42632,"RHEA_ID":40955,"DIRECTION":"UN","MASTER_ID":40955,"ec":"4.1.1.99","compounds":"(R)-5-phosphomevalonate + ATP = ADP + CO2 + isopentenyl phosphate + phosphate"}
{"X":42633,"RHEA_ID":40956,"DIRECTION":"LR","MASTER_ID":40955,"metacyc":"RXN-10067","compounds":"(R)-5-phosphomevalonate + ATP => ADP + CO2 + isopentenyl phosphate + phosphate"}
{"X":42634,"RHEA_ID":50928,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate"}
{"X":42635,"RHEA_ID":61166,"compounds":"H(+) + kaempferol 3-O-alpha-L-rhamnoside + UDP => kaempferol + UDP-beta-L-rhamnose"}
{"X":42636,"RHEA_ID":40959,"compounds":"2 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine = 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine"}
{"X":42637,"RHEA_ID":50931,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 <=> (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate"}
{"X":42638,"RHEA_ID":50932,"compounds":"(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate"}
{"X":42639,"RHEA_ID":40962,"compounds":"2 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine <=> 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine"}
{"X":42640,"RHEA_ID":40963,"DIRECTION":"UN","MASTER_ID":40963,"ec":"1.10.3.4","compounds":"4 2-aminophenol + 3 O2 = 2 2-aminophenoxazin-3-one + 6 H2O"}
{"X":42641,"RHEA_ID":50935,"compounds":"(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 <=> (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate"}
{"X":42642,"RHEA_ID":50936,"DIRECTION":"UN","MASTER_ID":50936,"ec":"2.6.1.111","compounds":"2-oxoglutarate + 3-aminobutanoyl-CoA = acetoacetyl-CoA + L-glutamate"}
{"X":42643,"RHEA_ID":61174,"compounds":"H(+) + myricetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP => myricetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose"}
{"X":42644,"RHEA_ID":40967,"compounds":"1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-glycerol + H(+)"}
{"X":42645,"RHEA_ID":61176,"compounds":"(E)-caffeoyl-CoA + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside = CoA + H(+) + quercetin 3-O-[(6-O-[(E)-caffeoyl]-beta-D-glucosyl)-(1->2)-beta-D-glucoside]"}
{"X":42646,"RHEA_ID":50940,"DIRECTION":"UN","MASTER_ID":50940,"ec":"2.3.2.20","compounds":"L-leucyl-tRNA(Leu) + L-phenylalanyl-tRNA(Phe) = cyclo(L-phenylalanyl-L-leucyl) + H(+) + tRNA(Leu) + tRNA(Phe)"}
{"X":42647,"RHEA_ID":40970,"compounds":"1,2-di-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-glycerol + H(+)"}
{"X":42648,"RHEA_ID":40971,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":42649,"RHEA_ID":50944,"compounds":"3-phenylpropanoate + NAD(+) = H(+) + NADH + trans-cinnamate"}
{"X":42650,"RHEA_ID":50945,"compounds":"3-phenylpropanoate + NAD(+) => H(+) + NADH + trans-cinnamate"}
{"X":42651,"RHEA_ID":40975,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2 H2O = 2 H(+) + 2 hexadecanoate + sn-glycerol 3-phosphocholine"}
{"X":42652,"RHEA_ID":61184,"compounds":"quercitrin + UDP-beta-L-rhamnose = H(+) + quercetin 3,7-bis-O-alpha-L-rhamnoside + UDP"}
{"X":42653,"RHEA_ID":50948,"DIRECTION":"UN","MASTER_ID":50948,"ec":"3.5.4.38","compounds":"a 2'-deoxycytidine in a single-stranded DNA + H(+) + H2O = a 2'-deoxyuridine in a single-stranded DNA + NH4(+)"}
{"X":42654,"RHEA_ID":50949,"compounds":"a 2'-deoxycytidine in a single-stranded DNA + H(+) + H2O => a 2'-deoxyuridine in a single-stranded DNA + NH4(+)"}
{"X":42655,"RHEA_ID":40979,"compounds":"1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)glycerol + H(+) + hexadecanoate"}
{"X":42656,"RHEA_ID":40980,"compounds":"1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O => 1-hexadecanoyl-2-(9Z-octadecenoyl)glycerol + H(+) + hexadecanoate"}
{"X":42657,"RHEA_ID":50952,"compounds":"7-chloro-L-tryptophan + AH2 + O2 = A + CO2 + 2 H2O + monodechloroaminopyrrolnitrin"}
{"X":42658,"RHEA_ID":50953,"DIRECTION":"LR","MASTER_ID":50952,"metacyc":"RXN-11795","compounds":"7-chloro-L-tryptophan + AH2 + O2 => A + CO2 + 2 H2O + monodechloroaminopyrrolnitrin"}
{"X":42659,"RHEA_ID":40983,"compounds":"1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O = (9Z)-octadecenoate + 1,3-dihexadecanoylglycerol + H(+)"}
{"X":42660,"RHEA_ID":61192,"compounds":"(E)-4-coumaroyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] = CoA + H(+) + myricetin 3-O-[(6-O-(E)-4-coumaroyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]"}
{"X":42661,"RHEA_ID":50956,"DIRECTION":"UN","MASTER_ID":50956,"ec":"2.1.1.268","compounds":"cytidine(32) in tRNA(Ser) + S-adenosyl-L-methionine = H(+) + N(3)-methylcytidine(32) in tRNA(Ser) + S-adenosyl-L-homocysteine"}
{"X":42662,"RHEA_ID":40986,"compounds":"1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O <=> (9Z)-octadecenoate + 1,3-dihexadecanoylglycerol + H(+)"}
{"X":42663,"RHEA_ID":40987,"DIRECTION":"UN","MASTER_ID":40987,"ec":"1.14.14.33","metacyc":"RXN-17509","compounds":"EDTA + 2 FMNH2 + 2 O2 = ethylenediaminediacetate + 2 FMN + 2 glyoxylate + 3 H(+) + 2 H2O"}
{"X":42664,"RHEA_ID":50959,"compounds":"cytidine(32) in tRNA(Ser) + S-adenosyl-L-methionine <=> H(+) + N(3)-methylcytidine(32) in tRNA(Ser) + S-adenosyl-L-homocysteine"}
{"X":42665,"RHEA_ID":40989,"compounds":"ethylenediaminediacetate + 2 FMN + 2 glyoxylate + 3 H(+) + 2 H2O => EDTA + 2 FMNH2 + 2 O2"}
{"X":42666,"RHEA_ID":61198,"compounds":"CoA + H(+) + myricetin 3-O-[(6-O-[(E)-feruloyl]-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside] => (E)-feruloyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside]"}
{"X":42667,"RHEA_ID":50962,"compounds":"H(+) + N(3)-methylcytidine(32) in tRNA(Thr) + S-adenosyl-L-homocysteine => cytidine(32) in tRNA(Thr) + S-adenosyl-L-methionine"}
{"X":42668,"RHEA_ID":50963,"compounds":"cytidine(32) in tRNA(Thr) + S-adenosyl-L-methionine <=> H(+) + N(3)-methylcytidine(32) in tRNA(Thr) + S-adenosyl-L-homocysteine"}
{"X":42669,"RHEA_ID":40993,"compounds":"3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA => (E)-4-coumaroyl-CoA + H2O"}
{"X":42670,"RHEA_ID":50965,"compounds":"cytidine(8) in tRNA + H(+) + H2O => NH4(+) + uridine(8) in tRNA"}
{"X":42671,"RHEA_ID":50966,"compounds":"NH4(+) + uridine(8) in tRNA => cytidine(8) in tRNA + H(+) + H2O"}
{"X":42672,"RHEA_ID":50967,"DIRECTION":"BI","MASTER_ID":50964,"metacyc":"RXN-13995","compounds":"cytidine(8) in tRNA + H(+) + H2O <=> NH4(+) + uridine(8) in tRNA"}
{"X":42673,"RHEA_ID":40997,"compounds":"4-hydroxybenzaldehyde + acetyl-CoA => 3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA"}
{"X":42674,"RHEA_ID":50969,"compounds":"adenosine(37) in tRNA(Ala) + H(+) + H2O => inosine(37) in tRNA(Ala) + NH4(+)"}
{"X":42675,"RHEA_ID":40999,"compounds":"1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycerol + H(+) + phosphocholine"}
{"X":42676,"RHEA_ID":41000,"compounds":"1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O => 1-tetradecanoyl-sn-glycerol + H(+) + phosphocholine"}
{"X":42677,"RHEA_ID":41001,"compounds":"1-tetradecanoyl-sn-glycerol + H(+) + phosphocholine => 1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":42678,"RHEA_ID":50973,"compounds":"(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2 => (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate"}
{"X":42679,"RHEA_ID":50974,"compounds":"(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2"}
{"X":42680,"RHEA_ID":50975,"compounds":"(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2 <=> (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate"}
{"X":42681,"RHEA_ID":41005,"compounds":"1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H(+) + phosphocholine => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O"}
{"X":42682,"RHEA_ID":50977,"compounds":"prostaglandin D2(out) => prostaglandin D2(in)"}
{"X":42683,"RHEA_ID":50978,"DIRECTION":"RL","MASTER_ID":50976,"reactome":"R-HSA-879528.1","compounds":"prostaglandin D2(in) => prostaglandin D2(out)"}
{"X":42684,"RHEA_ID":50979,"compounds":"prostaglandin D2(out) <=> prostaglandin D2(in)"}
{"X":42685,"RHEA_ID":41009,"compounds":"6-linalyl-2-O,3-dimethylflaviolin + diphosphate => (2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin"}
{"X":42686,"RHEA_ID":41010,"DIRECTION":"BI","MASTER_ID":41007,"metacyc":"RXN-15422","compounds":"(2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin <=> 6-linalyl-2-O,3-dimethylflaviolin + diphosphate"}
{"X":42687,"RHEA_ID":50982,"DIRECTION":"RL","MASTER_ID":50980,"reactome":"R-HSA-879528.1","compounds":"prostaglandin E1(in) => prostaglandin E1(out)"}
{"X":42688,"RHEA_ID":50983,"compounds":"prostaglandin E1(out) <=> prostaglandin E1(in)"}
{"X":42689,"RHEA_ID":41013,"compounds":"(+)-sesamin monocatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) => (+)-sesamin + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n"}
{"X":42690,"RHEA_ID":61222,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-CDP + 1D-myo-inositol 3-phosphate"}
{"X":42691,"RHEA_ID":50986,"compounds":"prostaglandin E2(in) => prostaglandin E2(out)"}
{"X":42692,"RHEA_ID":50987,"compounds":"prostaglandin E2(out) <=> prostaglandin E2(in)"}
{"X":42693,"RHEA_ID":41017,"compounds":"1-O-hexadecyl-2-acetyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol"}
{"X":42694,"RHEA_ID":41018,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol <=> 1-O-hexadecyl-2-acetyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA"}
{"X":42695,"RHEA_ID":41019,"compounds":"(9Z)-octadecenoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol = 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA"}
{"X":42696,"RHEA_ID":50991,"compounds":"prostaglandin F2alpha(out) <=> prostaglandin F2alpha(in)"}
{"X":42697,"RHEA_ID":41021,"compounds":"1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol"}
{"X":42698,"RHEA_ID":50993,"compounds":"thromboxane B2(out) => thromboxane B2(in)"}
{"X":42699,"RHEA_ID":41023,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycerol + octadecanoyl-CoA = 1-O-hexadecyl-2-acetyl-3-octadecanoyl-sn-glycerol + CoA"}
{"X":42700,"RHEA_ID":41024,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycerol + octadecanoyl-CoA => 1-O-hexadecyl-2-acetyl-3-octadecanoyl-sn-glycerol + CoA"}
{"X":42701,"RHEA_ID":41025,"compounds":"1-O-hexadecyl-2-acetyl-3-octadecanoyl-sn-glycerol + CoA => 1-O-hexadecyl-2-acetyl-sn-glycerol + octadecanoyl-CoA"}
{"X":42702,"RHEA_ID":41026,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycerol + octadecanoyl-CoA <=> 1-O-hexadecyl-2-acetyl-3-octadecanoyl-sn-glycerol + CoA"}
{"X":42703,"RHEA_ID":50998,"compounds":"[ribulose-1,5-bisphosphate carboxylase]-N(6),N(6),N(6)-trimethyl-L-lysine + 3 H(+) + 3 S-adenosyl-L-homocysteine => [ribulose-1,5-bisphosphate carboxylase]-L-lysine + 3 S-adenosyl-L-methionine"}
{"X":42704,"RHEA_ID":61236,"compounds":"H2O + L-methionine + O2 = 4-methylsulfanyl-2-oxobutanoate + H2O2 + NH4(+)"}
{"X":42705,"RHEA_ID":41029,"compounds":"1-O-hexadecyl-2-acetyl-3-tetradecanoyl-sn-glycerol + CoA => 1-O-hexadecyl-2-acetyl-sn-glycerol + tetradecanoyl-CoA"}
{"X":42706,"RHEA_ID":41030,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycerol + tetradecanoyl-CoA <=> 1-O-hexadecyl-2-acetyl-3-tetradecanoyl-sn-glycerol + CoA"}
{"X":42707,"RHEA_ID":41031,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycerol + decanoyl-CoA = 1-O-hexadecyl-2-acetyl-3-decanoyl-sn-glycerol + CoA"}
{"X":42708,"RHEA_ID":51003,"compounds":"[fructose-bisphosphate aldolase]-L-lysine + 3 S-adenosyl-L-methionine <=> [fructose-bisphosphate aldolase]-N(6),N(6),N(6)-trimethyl-L-lysine + 3 H(+) + 3 S-adenosyl-L-homocysteine"}
{"X":42709,"RHEA_ID":41033,"compounds":"1-O-hexadecyl-2-acetyl-3-decanoyl-sn-glycerol + CoA => 1-O-hexadecyl-2-acetyl-sn-glycerol + decanoyl-CoA"}
{"X":42710,"RHEA_ID":51005,"compounds":"2 [Fe(III)cytochrome cL] + a primary alcohol => 2 [Fe(II)cytochrome cL] + an aldehyde + 2 H(+)"}
{"X":42711,"RHEA_ID":51006,"compounds":"2 [Fe(II)cytochrome cL] + an aldehyde + 2 H(+) => 2 [Fe(III)cytochrome cL] + a primary alcohol"}
{"X":42712,"RHEA_ID":41037,"compounds":"1-O-hexadecyl-2-acetyl-3-hexadecanoyl-sn-glycerol + CoA => 1-O-hexadecyl-2-acetyl-sn-glycerol + hexadecanoyl-CoA"}
{"X":42713,"RHEA_ID":51008,"DIRECTION":"UN","MASTER_ID":51008,"ec":"1.1.2.10","compounds":"2 [Fe(III)cytochrome cL] + methanol = 2 [Fe(II)cytochrome cL] + formaldehyde + 2 H(+)"}
{"X":42714,"RHEA_ID":41039,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycerol + dodecanoyl-CoA = 1-O-hexadecyl-2-acetyl-3-dodecanoyl-sn-glycerol + CoA"}
{"X":42715,"RHEA_ID":51010,"compounds":"2 [Fe(II)cytochrome cL] + formaldehyde + 2 H(+) => 2 [Fe(III)cytochrome cL] + methanol"}
{"X":42716,"RHEA_ID":41041,"compounds":"1-O-hexadecyl-2-acetyl-3-dodecanoyl-sn-glycerol + CoA => 1-O-hexadecyl-2-acetyl-sn-glycerol + dodecanoyl-CoA"}
{"X":42717,"RHEA_ID":41042,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycerol + dodecanoyl-CoA <=> 1-O-hexadecyl-2-acetyl-3-dodecanoyl-sn-glycerol + CoA"}
{"X":42718,"RHEA_ID":51013,"compounds":"a monoacyl-sn-glycero-3-phosphocholine + H2O => a monoacylglycerol + H(+) + phosphocholine"}
{"X":42719,"RHEA_ID":51014,"compounds":"a monoacylglycerol + H(+) + phosphocholine => a monoacyl-sn-glycero-3-phosphocholine + H2O"}
{"X":42720,"RHEA_ID":41045,"compounds":"1-O-hexadecyl-2-acetyl-3-octanoyl-sn-glycerol + CoA => 1-O-hexadecyl-2-acetyl-sn-glycerol + octanoyl-CoA"}
{"X":42721,"RHEA_ID":51016,"DIRECTION":"UN","MASTER_ID":51016,"ec":"4.1.2.59","compounds":"7,8-dihydroneopterin 3'-phosphate = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde phosphate"}
{"X":42722,"RHEA_ID":41047,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA"}
{"X":42723,"RHEA_ID":61256,"compounds":"H2O + L-cysteine + O2 = 3-mercaptopyruvate + H2O2 + NH4(+)"}
{"X":42724,"RHEA_ID":41049,"compounds":"1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol"}
{"X":42725,"RHEA_ID":51020,"DIRECTION":"UN","MASTER_ID":51020,"ec":"1.1.2.8","compounds":"2 [Fe(III)cytochrome c] + a primary alcohol = 2 [Fe(II)cytochrome c] + an aldehyde + 2 H(+)"}
{"X":42726,"RHEA_ID":41051,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + tetradecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-tetradecanoyl-sn-glycerol + CoA"}
{"X":42727,"RHEA_ID":61260,"compounds":"H2O + L-glutamine + O2 = 2-oxoglutaramate + H2O2 + NH4(+)"}
{"X":42728,"RHEA_ID":41053,"compounds":"1,2-di-(9Z)-octadecenoyl-3-tetradecanoyl-sn-glycerol + CoA => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + tetradecanoyl-CoA"}
{"X":42729,"RHEA_ID":41054,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + tetradecanoyl-CoA <=> 1,2-di-(9Z)-octadecenoyl-3-tetradecanoyl-sn-glycerol + CoA"}
{"X":42730,"RHEA_ID":41055,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + dodecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-dodecanoyl-sn-glycerol + CoA"}
{"X":42731,"RHEA_ID":61264,"compounds":"H2O + L-alanine + O2 = H2O2 + NH4(+) + pyruvate"}
{"X":42732,"RHEA_ID":41057,"compounds":"1,2-di-(9Z)-octadecenoyl-3-dodecanoyl-sn-glycerol + CoA => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + dodecanoyl-CoA"}
{"X":42733,"RHEA_ID":51028,"compounds":"2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 = 7-chloroindole-3-pyruvate imine dimer + 2 H2O"}
{"X":42734,"RHEA_ID":41059,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + octadecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + CoA"}
{"X":42735,"RHEA_ID":61268,"compounds":"H2O + L-2-aminohexanoate + O2 = 2-oxohexanoate + H2O2 + NH4(+)"}
{"X":42736,"RHEA_ID":41061,"compounds":"1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + CoA => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + octadecanoyl-CoA"}
{"X":42737,"RHEA_ID":51032,"compounds":"7-chloroindole-3-pyruvate imine dimer = dichlorochromopyrrolate + H(+) + NH4(+)"}
{"X":42738,"RHEA_ID":41063,"compounds":"1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":42739,"RHEA_ID":51034,"compounds":"dichlorochromopyrrolate + H(+) + NH4(+) => 7-chloroindole-3-pyruvate imine dimer"}
{"X":42740,"RHEA_ID":41065,"compounds":"2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O"}
{"X":42741,"RHEA_ID":51036,"compounds":"2 2-iminio-3-(indol-3-yl)propanoate + H2O2 = 2 H2O + indole-3-pyruvate imine dimer"}
{"X":42742,"RHEA_ID":41067,"compounds":"1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":42743,"RHEA_ID":61276,"compounds":"H2O + L-ornithine + O2 = 5-amino-2-oxopentanoate + H2O2 + NH4(+)"}
{"X":42744,"RHEA_ID":41069,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":42745,"RHEA_ID":51040,"compounds":"indole-3-pyruvate imine dimer = chromopyrrolate + H(+) + NH4(+)"}
{"X":42746,"RHEA_ID":41071,"compounds":"1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":42747,"RHEA_ID":51042,"compounds":"chromopyrrolate + H(+) + NH4(+) => indole-3-pyruvate imine dimer"}
{"X":42748,"RHEA_ID":41073,"compounds":"1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":42749,"RHEA_ID":51044,"compounds":"indole-3-pyruvate imine dimer = CO2 + NH4(+) + protodeoxyviolaceinate"}
{"X":42750,"RHEA_ID":41075,"compounds":"1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+)"}
{"X":42751,"RHEA_ID":51046,"compounds":"CO2 + NH4(+) + protodeoxyviolaceinate => indole-3-pyruvate imine dimer"}
{"X":42752,"RHEA_ID":41077,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+) => 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O"}
{"X":42753,"RHEA_ID":51048,"DIRECTION":"UN","MASTER_ID":51048,"ec":"1.3.99.5","compounds":"5alpha-androstan-3,17-dione + A = AH2 + androst-4-ene-3,17-dione"}
{"X":42754,"RHEA_ID":41079,"compounds":"1-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":42755,"RHEA_ID":61288,"compounds":"5-deoxy-alpha-D-ribose + ATP = 5-deoxy-alpha-D-ribose 1-phosphate + ADP + H(+)"}
{"X":42756,"RHEA_ID":41081,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-(9Z-octadecenoyl)-sn-glycerol + ATP"}
{"X":42757,"RHEA_ID":41082,"compounds":"1-(9Z-octadecenoyl)-sn-glycerol + ATP <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":42758,"RHEA_ID":51053,"compounds":"5alpha-androstan-3,17-dione + A => 5alpha-androst-1-ene-3,17-dione + AH2"}
{"X":42759,"RHEA_ID":51054,"compounds":"5alpha-androst-1-ene-3,17-dione + AH2 => 5alpha-androstan-3,17-dione + A"}
{"X":42760,"RHEA_ID":41085,"compounds":"(9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":42761,"RHEA_ID":41086,"compounds":"1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":42762,"RHEA_ID":41087,"compounds":"1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine"}
{"X":42763,"RHEA_ID":61296,"compounds":"5-deoxy-alpha-D-ribose 1-phosphate = 5-deoxy-D-ribulose 1-phosphate"}
{"X":42764,"RHEA_ID":41089,"compounds":"1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol"}
{"X":42765,"RHEA_ID":41090,"compounds":"1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol <=> 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine"}
{"X":42766,"RHEA_ID":41091,"compounds":"a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycerol + H(+) + phosphocholine"}
{"X":42767,"RHEA_ID":44393,"compounds":"1-heptadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA => 1-heptadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":42768,"RHEA_ID":41093,"compounds":"1-(9Z-octadecenoyl)-sn-glycerol + H(+) + phosphocholine => a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O"}
{"X":42769,"RHEA_ID":41094,"compounds":"a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-(9Z-octadecenoyl)-sn-glycerol + H(+) + phosphocholine"}
{"X":42770,"RHEA_ID":41095,"compounds":"H2O + sphing-4-enine-phosphocholine = H(+) + phosphocholine + sphing-4-enine"}
{"X":42771,"RHEA_ID":51066,"compounds":"adenosine 3',5'-bisphosphate + H(+) + lithocholate sulfate => 3'-phosphoadenylyl sulfate + lithocholate"}
{"X":42772,"RHEA_ID":51067,"compounds":"3'-phosphoadenylyl sulfate + lithocholate <=> adenosine 3',5'-bisphosphate + H(+) + lithocholate sulfate"}
{"X":42773,"RHEA_ID":41098,"compounds":"H2O + sphing-4-enine-phosphocholine <=> H(+) + phosphocholine + sphing-4-enine"}
{"X":42774,"RHEA_ID":41099,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine"}
{"X":42775,"RHEA_ID":51070,"compounds":"(3S,5R,10R,12S,14S,15R,16R)-3,5,10,14,15-pentahydroxy-12,16-dimethylicosan-2-one + L-alanine => (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + pyruvate"}
{"X":42776,"RHEA_ID":51071,"DIRECTION":"BI","MASTER_ID":51068,"metacyc":"RXN-12266","compounds":"(2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + pyruvate <=> (3S,5R,10R,12S,14S,15R,16R)-3,5,10,14,15-pentahydroxy-12,16-dimethylicosan-2-one + L-alanine"}
{"X":42777,"RHEA_ID":41102,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine"}
{"X":42778,"RHEA_ID":41103,"compounds":"1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-3-octadecanoyl-sn-glycerol + H(+)"}
{"X":42779,"RHEA_ID":51074,"compounds":"a phenol + a phenyl sulfate => a phenol + a phenyl sulfate"}
{"X":42780,"RHEA_ID":54390,"compounds":"2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate => 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O"}
{"X":42781,"RHEA_ID":41106,"compounds":"1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-3-octadecanoyl-sn-glycerol + H(+)"}
{"X":42782,"RHEA_ID":41107,"compounds":"1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerol + H(+) + hexadecanoate"}
{"X":42783,"RHEA_ID":51078,"compounds":"2-hydroxy-17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+) => 2-hydroxy-17beta-estradiol + 3'-phosphoadenylyl sulfate"}
{"X":42784,"RHEA_ID":41109,"compounds":"2-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerol + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O"}
{"X":42785,"RHEA_ID":41110,"compounds":"1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O <=> 2-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerol + H(+) + hexadecanoate"}
{"X":42786,"RHEA_ID":41111,"compounds":"1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H(+) + octadecanoate"}
{"X":42787,"RHEA_ID":51082,"compounds":"19,20-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":42788,"RHEA_ID":51083,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 19,20-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":42789,"RHEA_ID":41114,"compounds":"1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H(+) + octadecanoate"}
{"X":42790,"RHEA_ID":41115,"compounds":"1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = 1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H(+) + phosphocholine"}
{"X":42791,"RHEA_ID":51086,"compounds":"16,17-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":42792,"RHEA_ID":51087,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 16,17-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":42793,"RHEA_ID":41118,"compounds":"1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O <=> 1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H(+) + phosphocholine"}
{"X":42794,"RHEA_ID":41119,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycerol + H(+) + phosphocholine"}
{"X":42795,"RHEA_ID":51090,"compounds":"13,14-epoxy-(4Z,7Z,10Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":42796,"RHEA_ID":51091,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 13,14-epoxy-(4Z,7Z,10Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":42797,"RHEA_ID":41122,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycerol + H(+) + phosphocholine"}
{"X":42798,"RHEA_ID":41123,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+)"}
{"X":42799,"RHEA_ID":61332,"compounds":"ATP + H2O + indoxyl sulfate(in) = ADP + H(+) + indoxyl sulfate(out) + phosphate"}
{"X":42800,"RHEA_ID":51095,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 10,11-epoxy-(4Z,7Z,13Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":42801,"RHEA_ID":41126,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+)"}
{"X":42802,"RHEA_ID":41127,"compounds":"1-dodecanoyl-sn-glycero-3-phosphocholine + H2O = 1-dodecanoyl-sn-glycerol + H(+) + phosphocholine"}
{"X":42803,"RHEA_ID":61336,"compounds":"ATP + H2O + protoporphyrin IX(in) = ADP + H(+) + phosphate + protoporphyrin IX(out)"}
{"X":42804,"RHEA_ID":51099,"compounds":"(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 19,20-epoxy-(7Z,10Z,13Z,16Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":42805,"RHEA_ID":41130,"compounds":"1-dodecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-dodecanoyl-sn-glycerol + H(+) + phosphocholine"}
{"X":42806,"RHEA_ID":41131,"compounds":"1-decanoyl-sn-glycero-3-phosphocholine + H2O = 1-decanoyl-sn-glycero-3-phosphate + choline + H(+)"}
{"X":42807,"RHEA_ID":51102,"compounds":"16,17-epoxy-(7Z,10Z,13Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":42808,"RHEA_ID":51103,"compounds":"(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 16,17-epoxy-(7Z,10Z,13Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":42809,"RHEA_ID":41134,"compounds":"1-decanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-decanoyl-sn-glycero-3-phosphate + choline + H(+)"}
{"X":42810,"RHEA_ID":41135,"compounds":"1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + choline + H(+)"}
{"X":42811,"RHEA_ID":51106,"compounds":"13,14-epoxy-(7Z,10Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":42812,"RHEA_ID":41137,"compounds":"1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + choline + H(+) => 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":42813,"RHEA_ID":41138,"compounds":"1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O <=> 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + choline + H(+)"}
{"X":42814,"RHEA_ID":41139,"compounds":"1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+)"}
{"X":42815,"RHEA_ID":61348,"compounds":"ATP + estrone 3-sulfate(in) + H2O = ADP + estrone 3-sulfate(out) + H(+) + phosphate"}
{"X":42816,"RHEA_ID":51111,"compounds":"(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 10,11-epoxy-(7Z,13Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":42817,"RHEA_ID":41142,"compounds":"1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+)"}
{"X":42818,"RHEA_ID":41143,"compounds":"1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)"}
{"X":42819,"RHEA_ID":61352,"compounds":"ATP + H2O + riboflavin(in) = ADP + H(+) + phosphate + riboflavin(out)"}
{"X":42820,"RHEA_ID":51115,"compounds":"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":42821,"RHEA_ID":41146,"compounds":"1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)"}
{"X":42822,"RHEA_ID":41147,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}
{"X":42823,"RHEA_ID":51118,"compounds":"H(+) + N(2)-methylguanosine(6) in tRNA + S-adenosyl-L-homocysteine => guanosine(6) in tRNA + S-adenosyl-L-methionine"}
{"X":42824,"RHEA_ID":61357,"compounds":"ATP + H2O + methotrexate(in) => ADP + H(+) + methotrexate(out) + phosphate"}
{"X":42825,"RHEA_ID":41150,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}
{"X":42826,"RHEA_ID":41151,"compounds":"1-hexadecanoyl-2-[9-hydroperoxy-(10E-octadecenoyl)]-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-hydroperoxy-10E-octadecenoate + H(+)"}
{"X":42827,"RHEA_ID":51122,"compounds":"(8S,15S)-dihydroxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 A + 2 H2O => (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 AH2"}
{"X":42828,"RHEA_ID":41153,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-hydroperoxy-10E-octadecenoate + H(+) => 1-hexadecanoyl-2-[9-hydroperoxy-(10E-octadecenoyl)]-sn-glycero-3-phosphocholine + H2O"}
{"X":42829,"RHEA_ID":41154,"compounds":"1-hexadecanoyl-2-[9-hydroperoxy-(10E-octadecenoyl)]-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-hydroperoxy-10E-octadecenoate + H(+)"}
{"X":42830,"RHEA_ID":51125,"compounds":"uridine in snRNA => pseudouridine in snRNA"}
{"X":42831,"RHEA_ID":51126,"compounds":"pseudouridine in snRNA => uridine in snRNA"}
{"X":42832,"RHEA_ID":41157,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + 10-hydroperoxy-8E-octadecenoate + H(+) => 1-hexadecanoyl-2-(10-hydroperoxy-8E-octadecenoyl)-sn-glycero-3-phosphocholine + H2O"}
{"X":42833,"RHEA_ID":41158,"compounds":"1-hexadecanoyl-2-(10-hydroperoxy-8E-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + 10-hydroperoxy-8E-octadecenoate + H(+)"}
{"X":42834,"RHEA_ID":51129,"compounds":"A + an aliphatic amine + H2O => AH2 + an aldehyde + NH4(+)"}
{"X":42835,"RHEA_ID":51130,"compounds":"AH2 + an aldehyde + NH4(+) => A + an aliphatic amine + H2O"}
{"X":42836,"RHEA_ID":41161,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + glutarate + H(+) => 1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O"}
{"X":42837,"RHEA_ID":41162,"compounds":"1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + glutarate + H(+)"}
{"X":42838,"RHEA_ID":51133,"compounds":"a purine 2'-deoxyribonucleoside 5'-phosphate + H2O => 2-deoxy-D-ribose 5-phosphate + a purine nucleobase"}
{"X":42839,"RHEA_ID":51134,"compounds":"2-deoxy-D-ribose 5-phosphate + a purine nucleobase => a purine 2'-deoxyribonucleoside 5'-phosphate + H2O"}
{"X":42840,"RHEA_ID":51135,"compounds":"a purine 2'-deoxyribonucleoside 5'-phosphate + H2O <=> 2-deoxy-D-ribose 5-phosphate + a purine nucleobase"}
{"X":42841,"RHEA_ID":41166,"compounds":"1-O-hexadecyl-2-amino-sn-glycerol + ATP <=> 1-O-hexadecyl-2-desoxy-2-amino-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":42842,"RHEA_ID":51137,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 2 O2 => (10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E,19Z)-docosahexaenoate"}
{"X":42843,"RHEA_ID":51138,"compounds":"(10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 2 O2"}
{"X":42844,"RHEA_ID":51139,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 2 O2 <=> (10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E,19Z)-docosahexaenoate"}
{"X":42845,"RHEA_ID":41170,"compounds":"a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)"}
{"X":42846,"RHEA_ID":51141,"compounds":"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + 2 O2 => (10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E)-docosapentaenoate"}
{"X":42847,"RHEA_ID":51142,"compounds":"(10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E)-docosapentaenoate => (4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + 2 O2"}
{"X":42848,"RHEA_ID":51143,"compounds":"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + 2 O2 <=> (10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E)-docosapentaenoate"}
{"X":42849,"RHEA_ID":41174,"compounds":"1-acyl-2-hexadecenoyl-sn-glycero-3-phosphate + H2O <=> 2-hexadecenoyl-sn-glycero-3-phosphate + a fatty acid + H(+)"}
{"X":42850,"RHEA_ID":51145,"compounds":"(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + 2 O2 => (10,17)-dihydroperoxy-(7Z,11Z,13Z,15E,19Z)-docosapentaenoate"}
{"X":42851,"RHEA_ID":51146,"compounds":"(10,17)-dihydroperoxy-(7Z,11Z,13Z,15E,19Z)-docosapentaenoate => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + 2 O2"}
{"X":42852,"RHEA_ID":51147,"compounds":"(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + 2 O2 <=> (10,17)-dihydroperoxy-(7Z,11Z,13Z,15E,19Z)-docosapentaenoate"}
{"X":42853,"RHEA_ID":51149,"compounds":"a primary alcohol + 2 oxidized [azurin] => an aldehyde + 2 H(+) + 2 reduced [azurin]"}
{"X":42854,"RHEA_ID":51150,"compounds":"an aldehyde + 2 H(+) + 2 reduced [azurin] => a primary alcohol + 2 oxidized [azurin]"}
{"X":42855,"RHEA_ID":41182,"compounds":"1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-oxononanoate + H(+)"}
{"X":42856,"RHEA_ID":51153,"DIRECTION":"LR","MASTER_ID":51152,"metacyc":"RXN-16226","compounds":"2 a thiol + L-cysteinyl-[sulfatase] + O2 => 3-oxo-L-alanyl-[sulfatase] + an organic disulfide + H(+) + H2O + hydrogen sulfide"}
{"X":42857,"RHEA_ID":51154,"compounds":"3-oxo-L-alanyl-[sulfatase] + an organic disulfide + H(+) + H2O + hydrogen sulfide => 2 a thiol + L-cysteinyl-[sulfatase] + O2"}
{"X":42858,"RHEA_ID":41185,"compounds":"1-O-octadecyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O"}
{"X":42859,"RHEA_ID":41186,"compounds":"1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-octadecyl-sn-glycero-3-phosphocholine + acetate + H(+)"}
{"X":42860,"RHEA_ID":51157,"compounds":"ATP + L-glutamate + tRNA(Glu) => AMP + diphosphate + L-glutamyl-tRNA(Gln)"}
{"X":42861,"RHEA_ID":51158,"compounds":"AMP + diphosphate + L-glutamyl-tRNA(Gln) => ATP + L-glutamate + tRNA(Glu)"}
{"X":42862,"RHEA_ID":51159,"compounds":"ATP + L-glutamate + tRNA(Glu) <=> AMP + diphosphate + L-glutamyl-tRNA(Gln)"}
{"X":42863,"RHEA_ID":41190,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + H2O <=> 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate"}
{"X":42864,"RHEA_ID":51161,"compounds":"cytidine(60) in tRNA(Asp) + S-adenosyl-L-methionine => 5-methylcytidine(60) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine"}
{"X":42865,"RHEA_ID":51162,"compounds":"5-methylcytidine(60) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine => cytidine(60) in tRNA(Asp) + S-adenosyl-L-methionine"}
{"X":42866,"RHEA_ID":51163,"compounds":"cytidine(60) in tRNA(Asp) + S-adenosyl-L-methionine <=> 5-methylcytidine(60) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine"}
{"X":42867,"RHEA_ID":41194,"compounds":"1-hexadecanoyl-2-propionyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + propanoate"}
{"X":42868,"RHEA_ID":51165,"compounds":"cytidine(61) in tRNA(Asp) + S-adenosyl-L-methionine => 5-methylcytidine(61) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine"}
{"X":42869,"RHEA_ID":51166,"compounds":"5-methylcytidine(61) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine => cytidine(61) in tRNA(Asp) + S-adenosyl-L-methionine"}
{"X":42870,"RHEA_ID":51167,"compounds":"cytidine(61) in tRNA(Asp) + S-adenosyl-L-methionine <=> 5-methylcytidine(61) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine"}
{"X":42871,"RHEA_ID":41198,"compounds":"1-hexadecanoyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + butanoate + H(+)"}
{"X":42872,"RHEA_ID":41199,"compounds":"1-hexadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate"}
{"X":42873,"RHEA_ID":61408,"compounds":"ATP + N(6)-(D-erythrulosyl)-L-lysine = ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysine"}
{"X":42874,"RHEA_ID":61409,"compounds":"ATP + N(6)-(D-erythrulosyl)-L-lysine => ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysine"}
{"X":42875,"RHEA_ID":41202,"compounds":"1-hexadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate"}
{"X":42876,"RHEA_ID":41203,"compounds":"1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)"}
{"X":42877,"RHEA_ID":61412,"compounds":"ATP + N-(D-erythrulosyl)-cadaverine = ADP + H(+) + N-(3-O-phospho-D-erythrulosyl)-cadaverine"}
{"X":42878,"RHEA_ID":51175,"compounds":"cytidine(62) in tRNA(Asp) + S-adenosyl-L-methionine <=> 5-methylcytidine(62) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine"}
{"X":42879,"RHEA_ID":41206,"compounds":"1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)"}
{"X":42880,"RHEA_ID":41207,"compounds":"1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)"}
{"X":42881,"RHEA_ID":51178,"compounds":"5-methylcytidine(48) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine => cytidine(48) in tRNA(Asp) + S-adenosyl-L-methionine"}
{"X":42882,"RHEA_ID":51179,"compounds":"cytidine(48) in tRNA(Asp) + S-adenosyl-L-methionine <=> 5-methylcytidine(48) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine"}
{"X":42883,"RHEA_ID":41210,"compounds":"1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)"}
{"X":42884,"RHEA_ID":41211,"DIRECTION":"UN","MASTER_ID":41211,"ec":"1.14.13.235","compounds":"(indol-3-yl)acetate + H(+) + NADH + O2 = 2-hydroxy-(1H-indol-3-yl)acetate + H2O + NAD(+)"}
{"X":42885,"RHEA_ID":61420,"DIRECTION":"UN","MASTER_ID":61420,"ec":"5.5.1.35","compounds":"(S)-8-oxocitronellyl enol = cis-cis-nepetalactol"}
{"X":42886,"RHEA_ID":51183,"compounds":"cytidine(49) in tRNA(Asp) + S-adenosyl-L-methionine <=> 5-methylcytidine(49) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine"}
{"X":42887,"RHEA_ID":51184,"compounds":"1-octadecanoyl-sn-glycero-3-phosphoserine + H2O = H(+) + octadecanoate + sn-glycero-3-phospho-L-serine"}
{"X":42888,"RHEA_ID":41215,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+)"}
{"X":42889,"RHEA_ID":61424,"DIRECTION":"UN","MASTER_ID":61424,"ec":"1.1.1.419","compounds":"cis-cis-nepetalactol + NAD(+) = cis-cis-nepetalactone + H(+) + NADH"}
{"X":42890,"RHEA_ID":41217,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O"}
{"X":42891,"RHEA_ID":41218,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+)"}
{"X":42892,"RHEA_ID":41219,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+)"}
{"X":42893,"RHEA_ID":51189,"DIRECTION":"LR","MASTER_ID":51188,"reactome":"R-HSA-3697855.1","compounds":"nitric oxide + superoxide => peroxynitrite"}
{"X":42894,"RHEA_ID":41221,"compounds":"(9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O"}
{"X":42895,"RHEA_ID":41222,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O <=> (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+)"}
{"X":42896,"RHEA_ID":41223,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":42897,"RHEA_ID":51191,"compounds":"nitric oxide + superoxide <=> peroxynitrite"}
{"X":42898,"RHEA_ID":41225,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":42899,"RHEA_ID":51193,"compounds":"(R)-2-hydroxyglutarate + NADP(+) => 2-oxoglutarate + H(+) + NADPH"}
{"X":42900,"RHEA_ID":41227,"DIRECTION":"UN","MASTER_ID":41227,"ec":"1.1.3.46","compounds":"(S)-4-hydroxymandelate + O2 = 4-hydroxyphenylglyoxylate + H2O2"}
{"X":42901,"RHEA_ID":61436,"compounds":"ADP + H2O = AMP + H(+) + phosphate"}
{"X":42902,"RHEA_ID":41229,"compounds":"4-hydroxyphenylglyoxylate + H2O2 => (S)-4-hydroxymandelate + O2"}
{"X":42903,"RHEA_ID":61438,"compounds":"AMP + H(+) + phosphate => ADP + H2O"}
{"X":42904,"RHEA_ID":41231,"compounds":"1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":42905,"RHEA_ID":51199,"compounds":"chloride(out) + Na(+)(out) + serotonin(out) <=> chloride(in) + Na(+)(in) + serotonin(in)"}
{"X":42906,"RHEA_ID":41233,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O"}
{"X":42907,"RHEA_ID":51201,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-retinylidene-N-retinylethanolamine => H2O + N-retinylidene-N-retinylphosphatidylethanolamine"}
{"X":42908,"RHEA_ID":41239,"compounds":"N-acyl (9Z,12Z)-octadecadienoate octadecasphin-4E-enine + O2 = N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine"}
{"X":42909,"RHEA_ID":61444,"compounds":"a tetracycline + H(+) + NADPH + O2 = an 11a-hydroxytetracycline + H2O + NADP(+)"}
{"X":42910,"RHEA_ID":41241,"compounds":"N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine => N-acyl (9Z,12Z)-octadecadienoate octadecasphin-4E-enine + O2"}
{"X":42911,"RHEA_ID":51205,"compounds":"6-trans-leukotriene B4 + NADP(+) => 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH"}
{"X":42912,"RHEA_ID":41243,"compounds":"N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine = N-acyl-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecenoate (4E)-octadecasphin-4-enine"}
{"X":42913,"RHEA_ID":61448,"compounds":"H(+) + NADPH + O2 + tigecycline = 11a-hydroxytigecycline + H2O + NADP(+)"}
{"X":42914,"RHEA_ID":41245,"compounds":"N-acyl-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecenoate (4E)-octadecasphin-4-enine => N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine"}
{"X":42915,"RHEA_ID":51209,"compounds":"20-hydroxy-leukotriene B4 + NADP(+) => 12-oxo-20-hydroxy-leukotriene B4 + H(+) + NADPH"}
{"X":42916,"RHEA_ID":41247,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 9R-hydroperoxy(5Z,7E,11Z,14Z)-eicosatetraenoate"}
{"X":42917,"RHEA_ID":51211,"compounds":"20-hydroxy-leukotriene B4 + NADP(+) <=> 12-oxo-20-hydroxy-leukotriene B4 + H(+) + NADPH"}
{"X":42918,"RHEA_ID":41249,"compounds":"9R-hydroperoxy(5Z,7E,11Z,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2"}
{"X":42919,"RHEA_ID":51213,"compounds":"(5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP(+) => 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH"}
{"X":42920,"RHEA_ID":41251,"compounds":"(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = 7R-hydroxy-5S,6S-epoxy-(8Z,11Z,14Z)-eicosatrienoate"}
{"X":42921,"RHEA_ID":51215,"compounds":"(5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP(+) <=> 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH"}
{"X":42922,"RHEA_ID":41253,"compounds":"7R-hydroxy-5S,6S-epoxy-(8Z,11Z,14Z)-eicosatrienoate => (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate"}
{"X":42923,"RHEA_ID":41254,"compounds":"(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate <=> 7R-hydroxy-5S,6S-epoxy-(8Z,11Z,14Z)-eicosatrienoate"}
{"X":42924,"RHEA_ID":41255,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate"}
{"X":42925,"RHEA_ID":51219,"compounds":"3'-phosphoadenylyl sulfate + 3beta-hydroxyandrost-5-en-17-one <=> 3beta-sulfooxy-androst-5-en-17-one + adenosine 3',5'-bisphosphate + H(+)"}
{"X":42926,"RHEA_ID":41257,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O"}
{"X":42927,"RHEA_ID":51221,"DIRECTION":"LR","MASTER_ID":51220,"reactome":"R-HSA-3301943.1","compounds":"1-chloro-2,4-dinitrobenzene + glutathione => 2,4-dinitrophenyl-S-glutathione + chloride + H(+)"}
{"X":42928,"RHEA_ID":41259,"DIRECTION":"UN","MASTER_ID":41259,"ec":"4.3.1.31","compounds":"L-tryptophan = (E)-3-(indol-3-yl)acrylate + NH4(+)"}
{"X":42929,"RHEA_ID":61464,"compounds":"a cytidine in mRNA + S-adenosyl-L-methionine = a 5-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":42930,"RHEA_ID":41261,"compounds":"(E)-3-(indol-3-yl)acrylate + NH4(+) => L-tryptophan"}
{"X":42931,"RHEA_ID":51225,"DIRECTION":"LR","MASTER_ID":51224,"metacyc":"RXN-18796","compounds":"2 [Fe(III)cytochrome c] + S-sulfanyl-L-cysteinyl-[SoxY protein] + thiosulfate => 2 [Fe(II)cytochrome c] + 2 H(+) + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein]"}
{"X":42932,"RHEA_ID":41263,"compounds":"NAD(+) + prostaglandin A1 = 15-keto-prostaglandin A1 + H(+) + NADH"}
{"X":42933,"RHEA_ID":61468,"compounds":"a cytidine in tRNA + S-adenosyl-L-methionine = a 5-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":42934,"RHEA_ID":41265,"compounds":"15-keto-prostaglandin A1 + H(+) + NADH => NAD(+) + prostaglandin A1"}
{"X":42935,"RHEA_ID":51229,"compounds":"17alpha-ethynylestradiol + 3'-phosphoadenylyl sulfate => 17alpha-ethynylestradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)"}
{"X":42936,"RHEA_ID":41267,"compounds":"H2O + N-(15Z-tetracosenoyl)-sphing-4-enine = (15Z)-tetracosenoate + sphing-4-enine"}
{"X":42937,"RHEA_ID":61472,"DIRECTION":"UN","MASTER_ID":61472,"ec":"2.3.1.291","compounds":"a sphingoid base + hexadecanoyl-CoA = an N-hexadecanoyl-sphingoid base + CoA + H(+)"}
{"X":42938,"RHEA_ID":41269,"compounds":"(15Z)-tetracosenoate + sphing-4-enine => H2O + N-(15Z-tetracosenoyl)-sphing-4-enine"}
{"X":42939,"RHEA_ID":51233,"compounds":"2-glyceryl-prostaglandin H2 => 2-glyceryl-prostaglandin D2"}
{"X":42940,"RHEA_ID":41271,"compounds":"1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":42941,"RHEA_ID":51235,"compounds":"2-glyceryl-prostaglandin H2 <=> 2-glyceryl-prostaglandin D2"}
{"X":42942,"RHEA_ID":41273,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-O-hexadecyl-sn-glycero-3-phosphocholine + H2O"}
{"X":42943,"RHEA_ID":51237,"compounds":"GTP + L-glutamate + oxidized coenzyme F420-(gamma-Glu)(n) => GDP + H(+) + oxidized coenzyme F420-(gamma-Glu)(n+1) + phosphate"}
{"X":42944,"RHEA_ID":41275,"compounds":"H2O + N-eicosanoyl-sphing-4-enine = eicosanoate + sphing-4-enine"}
{"X":42945,"RHEA_ID":61480,"DIRECTION":"UN","MASTER_ID":61480,"ec":"2.3.1.297","compounds":"a sphingoid base + a very long-chain fatty acyl-CoA = an N-(very-long-chain fatty acyl)-sphingoid base + CoA + H(+)"}
{"X":42946,"RHEA_ID":41277,"compounds":"eicosanoate + sphing-4-enine => H2O + N-eicosanoyl-sphing-4-enine"}
{"X":42947,"RHEA_ID":51241,"compounds":"(9Z,12Z)-octadecadienoate + O2 => (13R)-hydroperoxy-(9Z,11E)-octadecadienoate"}
{"X":42948,"RHEA_ID":41279,"compounds":"H2O + N-octadecanoylsphing-4-enine = octadecanoate + sphing-4-enine"}
{"X":42949,"RHEA_ID":41280,"compounds":"H2O + N-octadecanoylsphing-4-enine => octadecanoate + sphing-4-enine"}
{"X":42950,"RHEA_ID":41281,"compounds":"octadecanoate + sphing-4-enine => H2O + N-octadecanoylsphing-4-enine"}
{"X":42951,"RHEA_ID":41282,"compounds":"H2O + N-octadecanoylsphing-4-enine <=> octadecanoate + sphing-4-enine"}
{"X":42952,"RHEA_ID":41283,"compounds":"H2O + N-(tetracosanoyl)-sphing-4-enine = sphing-4-enine + tetracosanoate"}
{"X":42953,"RHEA_ID":41284,"compounds":"H2O + N-(tetracosanoyl)-sphing-4-enine => sphing-4-enine + tetracosanoate"}
{"X":42954,"RHEA_ID":41285,"compounds":"sphing-4-enine + tetracosanoate => H2O + N-(tetracosanoyl)-sphing-4-enine"}
{"X":42955,"RHEA_ID":51249,"DIRECTION":"LR","MASTER_ID":51248,"metacyc":"RXN-8497","compounds":"(9Z,12Z,15Z)-octadecatrienoate + O2 => (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate"}
{"X":42956,"RHEA_ID":41287,"compounds":"H2O + N-tetradecanoylsphing-4-enine = sphing-4-enine + tetradecanoate"}
{"X":42957,"RHEA_ID":51251,"compounds":"(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate"}
{"X":42958,"RHEA_ID":41289,"compounds":"sphing-4-enine + tetradecanoate => H2O + N-tetradecanoylsphing-4-enine"}
{"X":42959,"RHEA_ID":51253,"compounds":"(9Z,12Z,15Z)-octadecatrienoate + O2 => (11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate"}
{"X":42960,"RHEA_ID":41291,"compounds":"H2O + N-dodecanoylsphing-4-enine = dodecanoate + sphing-4-enine"}
{"X":42961,"RHEA_ID":51255,"compounds":"(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate"}
{"X":42962,"RHEA_ID":41293,"compounds":"dodecanoate + sphing-4-enine => H2O + N-dodecanoylsphing-4-enine"}
{"X":42963,"RHEA_ID":51257,"compounds":"(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate + O2 => (9S,16S)-dihydroperoxy-(10E,12Z,14E)-octadecatrienoate"}
{"X":42964,"RHEA_ID":41295,"compounds":"H2O + N-(hexanoyl)sphing-4-enine = hexanoate + sphing-4-enine"}
{"X":42965,"RHEA_ID":51259,"compounds":"(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate + O2 <=> (9S,16S)-dihydroperoxy-(10E,12Z,14E)-octadecatrienoate"}
{"X":42966,"RHEA_ID":41297,"compounds":"hexanoate + sphing-4-enine => H2O + N-(hexanoyl)sphing-4-enine"}
{"X":42967,"RHEA_ID":51261,"DIRECTION":"LR","MASTER_ID":51260,"metacyc":"RXN-18142","compounds":"4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase] => (10bR,4aS)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":42968,"RHEA_ID":41299,"compounds":"H2O + N-(9Z-octadecenoyl)-sphing-4-enine = (9Z)-octadecenoate + sphing-4-enine"}
{"X":42969,"RHEA_ID":54581,"compounds":"5'-dephospho-(RNA) + ATP => 5'-end-(RNA) + ADP + H(+)"}
{"X":42970,"RHEA_ID":41301,"compounds":"(9Z)-octadecenoate + sphing-4-enine => H2O + N-(9Z-octadecenoyl)-sphing-4-enine"}
{"X":42971,"RHEA_ID":51265,"DIRECTION":"LR","MASTER_ID":51264,"metacyc":"RXN-18127","compounds":"4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase] => (10bS,4aR)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":42972,"RHEA_ID":41303,"compounds":"H2O + N-(dodecanoyl)-4-hydroxysphinganine = 4-hydroxysphinganine + dodecanoate"}
{"X":42973,"RHEA_ID":54585,"compounds":"a guanosine in 18S rRNA + S-adenosyl-L-methionine => an N(7)-methylguanosine in 18S rRNA + S-adenosyl-L-homocysteine"}
{"X":42974,"RHEA_ID":41305,"compounds":"4-hydroxysphinganine + dodecanoate => H2O + N-(dodecanoyl)-4-hydroxysphinganine"}
{"X":42975,"RHEA_ID":51269,"DIRECTION":"LR","MASTER_ID":51268,"metacyc":"RXN-18122","compounds":"norbelladine + S-adenosyl-L-methionine => 4'-O-methylnorbelladine + H(+) + S-adenosyl-L-homocysteine"}
{"X":42976,"RHEA_ID":41307,"compounds":"1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z,15Z)-octadecatrienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":42977,"RHEA_ID":61512,"compounds":"malvidin + UDP-alpha-D-glucose = malvidin 3-O-beta-D-glucoside + UDP"}
{"X":42978,"RHEA_ID":41309,"compounds":"(9Z,12Z,15Z)-octadecatrienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H2O"}
{"X":42979,"RHEA_ID":51273,"compounds":"(9Z)-octadecenoyl-CoA + glycine => CoA + H(+) + N-(9Z-octadecenoyl)glycine"}
{"X":42980,"RHEA_ID":41311,"compounds":"1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl (5Z,8Z,10E,12R,14Z)-hydroperoxyiecosatetraenoate"}
{"X":42981,"RHEA_ID":51275,"compounds":"(9Z)-octadecenoyl-CoA + glycine <=> CoA + H(+) + N-(9Z-octadecenoyl)glycine"}
{"X":42982,"RHEA_ID":41313,"compounds":"1-O-methyl (5Z,8Z,10E,12R,14Z)-hydroperoxyiecosatetraenoate => 1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2"}
{"X":42983,"RHEA_ID":51277,"compounds":"(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate => (9S)-hydroperoxy-(10E,12Z)-octadecadienoate"}
{"X":42984,"RHEA_ID":41315,"compounds":"1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate"}
{"X":42985,"RHEA_ID":61524,"compounds":"(8Z,11Z,14Z)-eicosatrienoate + O2 = (15S)-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate"}
{"X":42986,"RHEA_ID":41317,"compounds":"1-O-methyl-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => 1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2"}
{"X":42987,"RHEA_ID":41318,"compounds":"1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate"}
{"X":42988,"RHEA_ID":41320,"compounds":"1-O-(9Z)-octadecenoyl-2-O-acetyl-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 2-acetyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":42989,"RHEA_ID":51283,"compounds":"(13R)-hydroperoxy-(9Z,11E)-octadecadienoate <=> (9S)-hydroperoxy-(10E,12Z)-octadecadienoate"}
{"X":42990,"RHEA_ID":41322,"compounds":"(9Z)-octadecenoate + 2-acetyl-sn-glycero-3-phosphocholine + H(+) => 1-O-(9Z)-octadecenoyl-2-O-acetyl-sn-glycero-3-phosphocholine + H2O"}
{"X":42991,"RHEA_ID":51285,"compounds":"(11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate => (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate"}
{"X":42992,"RHEA_ID":41324,"compounds":"(5Z,8Z,11Z)-eicosatrienoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E)-eicosatrienoate"}
{"X":42993,"RHEA_ID":51287,"compounds":"(11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate <=> (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate"}
{"X":42994,"RHEA_ID":51288,"compounds":"(11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate = (13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate"}
{"X":42995,"RHEA_ID":51289,"compounds":"(11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate => (13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate"}
{"X":42996,"RHEA_ID":41328,"compounds":"(8Z,11Z,14Z)-eicosatrienoate + O2 = (12S)-hydroperoxy-(8Z,10E,14Z)-eicosatrienoate"}
{"X":42997,"RHEA_ID":51291,"compounds":"(11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate <=> (13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate"}
{"X":42998,"RHEA_ID":51292,"compounds":"a quinone + H2O + L-methionyl-[protein] = a quinol + L-methionyl-(S)-S-oxide-[protein]"}
{"X":42999,"RHEA_ID":51293,"compounds":"a quinone + H2O + L-methionyl-[protein] => a quinol + L-methionyl-(S)-S-oxide-[protein]"}
{"X":43000,"RHEA_ID":41332,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate"}
{"X":43001,"RHEA_ID":41333,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => (14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate"}
{"X":43002,"RHEA_ID":51296,"compounds":"a quinone + H2O + L-methionyl-[protein] = a quinol + L-methionyl-(R)-S-oxide-[protein]"}
{"X":43003,"RHEA_ID":41335,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> (14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate"}
{"X":43004,"RHEA_ID":41336,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate"}
{"X":43005,"RHEA_ID":61576,"DIRECTION":"UN","MASTER_ID":61576,"ec":"1.3.1.120","compounds":"(4R,5R)-4,5-dihydroxycyclohex-2-ene-1-carbonyl-CoA + NADP(+) = (3R,4R)-3,4-dihydroxycyclohexa-1,5-diene-1-carbonyl-CoA + H(+) + NADPH"}
{"X":43006,"RHEA_ID":41338,"compounds":"(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2"}
{"X":43007,"RHEA_ID":41339,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate"}
{"X":43008,"RHEA_ID":41340,"compounds":"(6Z,9Z,12Z)-octadecatrienoate + O2 = 10R-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate"}
{"X":43009,"RHEA_ID":51303,"compounds":"(9Z)-octadecenoate + L-phenylalanine <=> H2O + N-(9Z-octadecenoyl)-L-phenylalanine"}
{"X":43010,"RHEA_ID":61581,"compounds":"(3S)-3-hydroxycyclohexane-1-carbonyl-CoA + NADP(+) => (5S)-5-hydroxycyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH"}
{"X":43011,"RHEA_ID":41343,"compounds":"(6Z,9Z,12Z)-octadecatrienoate + O2 <=> 10R-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate"}
{"X":43012,"RHEA_ID":41344,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = (5Z,7Z,8Z,10E,14Z,17Z)-12-hydroperoxyeicosapentaenoate"}
{"X":43013,"RHEA_ID":51307,"compounds":"(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate <=> (13R)-hydroperoxy-(9Z,11E)-octadecadienoate"}
{"X":43014,"RHEA_ID":51308,"DIRECTION":"UN","MASTER_ID":51308,"ec":"1.14.13.225","compounds":"H(+) + L-methionyl-[F-actin] + NADPH + O2 = H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+)"}
{"X":43015,"RHEA_ID":41347,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 <=> (5Z,7Z,8Z,10E,14Z,17Z)-12-hydroperoxyeicosapentaenoate"}
{"X":43016,"RHEA_ID":41348,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate"}
{"X":43017,"RHEA_ID":51311,"compounds":"H(+) + L-methionyl-[F-actin] + NADPH + O2 <=> H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+)"}
{"X":43018,"RHEA_ID":61589,"DIRECTION":"LR","MASTER_ID":61588,"metacyc":"RXN-20941","compounds":"amicoumacin A + ATP => ADP + amicoumacin A 2-phosphate + H(+)"}
{"X":43019,"RHEA_ID":41351,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate"}
{"X":43020,"RHEA_ID":41352,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) = a 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine"}
{"X":43021,"RHEA_ID":51315,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine <=> H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine"}
{"X":43022,"RHEA_ID":51316,"compounds":"(9Z)-octadecenoate + glycine = H2O + N-(9Z-octadecenoyl)glycine"}
{"X":43023,"RHEA_ID":41355,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> a 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine"}
{"X":43024,"RHEA_ID":41356,"DIRECTION":"UN","MASTER_ID":41356,"ec":"1.3.1.111","compounds":"bacteriochlorophyll a + 3 NADP(+) = geranylgeranyl-bacteriochlorophyllide a + 3 H(+) + 3 NADPH"}
{"X":43025,"RHEA_ID":51319,"compounds":"(9Z)-octadecenoate + glycine <=> H2O + N-(9Z-octadecenoyl)glycine"}
{"X":43026,"RHEA_ID":51324,"compounds":"(8Z,11Z,14Z)-eicosatrienoate + O2 = (8R)-hydroperoxy-(9E,11Z,14Z)-eicosatrienoate"}
{"X":43027,"RHEA_ID":51325,"compounds":"(8Z,11Z,14Z)-eicosatrienoate + O2 => (8R)-hydroperoxy-(9E,11Z,14Z)-eicosatrienoate"}
{"X":43028,"RHEA_ID":41360,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = H(+) + hexadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":43029,"RHEA_ID":41361,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine => H(+) + hexadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":43030,"RHEA_ID":61605,"DIRECTION":"LR","MASTER_ID":61604,"metacyc":"RXN-20000","compounds":"[DsbA protein]-dithiol + [DsbB protein]-disulfide => [DsbA protein]-disulfide + [DsbB protein]-dithiol"}
{"X":43031,"RHEA_ID":41363,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine <=> H(+) + hexadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":43032,"RHEA_ID":41364,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + a 2-acyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + 2-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":43033,"RHEA_ID":41365,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + a 2-acyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + 2-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":43034,"RHEA_ID":41366,"compounds":"1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + 2-hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + a 2-acyl-sn-glycero-3-phosphocholine"}
{"X":43035,"RHEA_ID":41367,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + a 2-acyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + 2-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":43036,"RHEA_ID":41368,"compounds":"2-O-acetyl-1-O-tetradecyl-sn-glycero-3-phosphocholine + H2O = 1-O-tetradecyl-sn-glycero-3-phosphocholine + acetate + H(+)"}
{"X":43037,"RHEA_ID":51335,"compounds":"(8Z,11Z,14Z)-eicosatrienoate + O2 <=> 11-hydroperoxy-(8Z,12E,14Z)-eicosatrienoate"}
{"X":43038,"RHEA_ID":54650,"DIRECTION":"RL","MASTER_ID":54648,"metacyc":"RXN-18891","compounds":"all-trans-geranylgeranyl diphosphate + H2O => ent-8alpha-hydroxylabd-13-en-15-yl diphosphate"}
{"X":43039,"RHEA_ID":41371,"compounds":"2-O-acetyl-1-O-tetradecyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-tetradecyl-sn-glycero-3-phosphocholine + acetate + H(+)"}
{"X":43040,"RHEA_ID":41372,"compounds":"1-O-dodecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-dodecyl-sn-glycero-3-phosphocholine + acetate + H(+)"}
{"X":43041,"RHEA_ID":51339,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 <=> 8-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate"}
{"X":43042,"RHEA_ID":61621,"DIRECTION":"LR","MASTER_ID":61620,"metacyc":"RXN-20951","compounds":"[(1->2)-beta-D-mannosyl](n) + GDP-alpha-D-mannose => [(1->2)-beta-D-mannosyl](n+1) + GDP + H(+)"}
{"X":43043,"RHEA_ID":41375,"compounds":"1-O-dodecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-dodecyl-sn-glycero-3-phosphocholine + acetate + H(+)"}
{"X":43044,"RHEA_ID":41376,"compounds":"1-O-decyl-2-O-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-decyl-sn-glycero-3-phosphocholine + acetate + H(+)"}
{"X":43045,"RHEA_ID":51343,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> 10-hydroperoxy-(4Z,7Z,11E,13Z,16Z,19Z)-docosahexaenoate"}
{"X":43046,"RHEA_ID":51344,"compounds":"(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate = 8,9-epoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O"}
{"X":43047,"RHEA_ID":41379,"compounds":"1-O-decyl-2-O-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-decyl-sn-glycero-3-phosphocholine + acetate + H(+)"}
{"X":43048,"RHEA_ID":41380,"DIRECTION":"UN","MASTER_ID":41380,"ec":"1.14.13.236","compounds":"H(+) + NADH + O2 + toluene = 4-methylphenol + H2O + NAD(+)"}
{"X":43049,"RHEA_ID":41381,"DIRECTION":"LR","MASTER_ID":41380,"metacyc":"TOLUENE-4-MONOOXYGENASE-RXN","compounds":"H(+) + NADH + O2 + toluene => 4-methylphenol + H2O + NAD(+)"}
{"X":43050,"RHEA_ID":61629,"compounds":"5-aminopentanal => 1-piperideine + H2O"}
{"X":43051,"RHEA_ID":51349,"compounds":"acetyl-CoA + 10 AH2 + 2 H(+) + 7 malonyl-CoA + 5 S-adenosyl-L-methionine => 10 A + 7 CO2 + 8 CoA + dehydroprobetaenone I + 6 H2O + 5 S-adenosyl-L-homocysteine"}
{"X":43052,"RHEA_ID":41384,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":43053,"RHEA_ID":51351,"compounds":"acetyl-CoA + 10 AH2 + 2 H(+) + 7 malonyl-CoA + 5 S-adenosyl-L-methionine <=> 10 A + 7 CO2 + 8 CoA + dehydroprobetaenone I + 6 H2O + 5 S-adenosyl-L-homocysteine"}
{"X":43054,"RHEA_ID":54666,"compounds":"pre-alpha-onocerin => (3S,22S)-2,3:22,23-diepoxy-2,3,22,23-tetrahydrosqualene"}
{"X":43055,"RHEA_ID":41387,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> H(+) + hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":43056,"RHEA_ID":41388,"compounds":"1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate"}
{"X":43057,"RHEA_ID":41389,"compounds":"1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate"}
{"X":43058,"RHEA_ID":61641,"DIRECTION":"LR","MASTER_ID":61640,"metacyc":"RXN-20752","compounds":"H(+) + isophthalyl-CoA => benzoyl-CoA + CO2"}
{"X":43059,"RHEA_ID":41391,"compounds":"1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate"}
{"X":43060,"RHEA_ID":41392,"compounds":"2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+)"}
{"X":43061,"RHEA_ID":51359,"compounds":"H2O + N-(9Z-octadecenoyl)-L-glutamine <=> (9Z)-octadecenoate + L-glutamine"}
{"X":43062,"RHEA_ID":51360,"compounds":"H2O + N-(9Z-octadecenoyl)-L-leucine = (9Z)-octadecenoate + L-leucine"}
{"X":43063,"RHEA_ID":41395,"compounds":"2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O <=> 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+)"}
{"X":43064,"RHEA_ID":41396,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine = 1-O-(1Z-alkenyl)-2-acetyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine"}
{"X":43065,"RHEA_ID":51363,"compounds":"H2O + N-(9Z-octadecenoyl)-L-leucine <=> (9Z)-octadecenoate + L-leucine"}
{"X":43066,"RHEA_ID":41398,"compounds":"1-O-(1Z-alkenyl)-2-acetyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine"}
{"X":43067,"RHEA_ID":51365,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine => CoA + H(+) + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine"}
{"X":43068,"RHEA_ID":41400,"compounds":"1-hexanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexanoyl-sn-glycero-3-phosphate + choline + H(+)"}
{"X":43069,"RHEA_ID":51367,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine <=> CoA + H(+) + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine"}
{"X":43070,"RHEA_ID":41402,"compounds":"1-hexanoyl-sn-glycero-3-phosphate + choline + H(+) => 1-hexanoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":43071,"RHEA_ID":51369,"compounds":"glycine + octadecanoyl-CoA => CoA + H(+) + N-octadecanoylglycine"}
{"X":43072,"RHEA_ID":41404,"DIRECTION":"UN","MASTER_ID":41404,"ec":"1.5.1.48","metacyc":"RXN-15301","compounds":"(R)-2-methylpyrrolidine + NADP(+) = 2-methyl-1-pyrroline + H(+) + NADPH"}
{"X":43073,"RHEA_ID":51371,"compounds":"glycine + octadecanoyl-CoA <=> CoA + H(+) + N-octadecanoylglycine"}
{"X":43074,"RHEA_ID":51372,"compounds":"(9Z)-hexadecenoyl-CoA + glycine = CoA + H(+) + N-(9Z-hexadecenoyl)-glycine"}
{"X":43075,"RHEA_ID":51374,"compounds":"CoA + H(+) + N-(9Z-hexadecenoyl)-glycine => (9Z)-hexadecenoyl-CoA + glycine"}
{"X":43076,"RHEA_ID":41409,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine => 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + N-(acetyl)-sphing-4-enine"}
{"X":43077,"RHEA_ID":51376,"compounds":"dopamine + hexadecanoyl-CoA = CoA + H(+) + N-hexadecanoyl-dopamine"}
{"X":43078,"RHEA_ID":41411,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + N-(acetyl)-sphing-4-enine"}
{"X":43079,"RHEA_ID":51378,"compounds":"CoA + H(+) + N-hexadecanoyl-dopamine => dopamine + hexadecanoyl-CoA"}
{"X":43080,"RHEA_ID":51379,"compounds":"dopamine + hexadecanoyl-CoA <=> CoA + H(+) + N-hexadecanoyl-dopamine"}
{"X":43081,"RHEA_ID":51380,"compounds":"(9Z)-octadecenoyl-CoA + dopamine = CoA + H(+) + N-(9Z-octadecanoyl)-dopamine"}
{"X":43082,"RHEA_ID":41415,"compounds":"1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1,2-didecanoyl-sn-glycero-3-phosphate + choline + H(+)"}
{"X":43083,"RHEA_ID":41416,"compounds":"1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dioctanoyl-sn-glycero-3-phosphate + choline + H(+)"}
{"X":43084,"RHEA_ID":51383,"compounds":"(9Z)-octadecenoyl-CoA + dopamine <=> CoA + H(+) + N-(9Z-octadecanoyl)-dopamine"}
{"X":43085,"RHEA_ID":51384,"compounds":"hexadecanoyl-CoA + serotonin = CoA + H(+) + N-hexadecanoyl-serotonin"}
{"X":43086,"RHEA_ID":41419,"compounds":"1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phosphate + choline + H(+)"}
{"X":43087,"RHEA_ID":51386,"compounds":"CoA + H(+) + N-hexadecanoyl-serotonin => hexadecanoyl-CoA + serotonin"}
{"X":43088,"RHEA_ID":51387,"compounds":"hexadecanoyl-CoA + serotonin <=> CoA + H(+) + N-hexadecanoyl-serotonin"}
{"X":43089,"RHEA_ID":51388,"compounds":"acetyl-CoA + dopamine = CoA + H(+) + N-acetyl-dopamine"}
{"X":43090,"RHEA_ID":51389,"compounds":"acetyl-CoA + dopamine => CoA + H(+) + N-acetyl-dopamine"}
{"X":43091,"RHEA_ID":41424,"DIRECTION":"UN","MASTER_ID":41424,"ec":"1.10.3.15","compounds":"2 3-amino-4-hydroxybenzaldehyde + N-acetyl-L-cysteine + 2 O2 = formate + grixazone A + H(+) + 3 H2O"}
{"X":43092,"RHEA_ID":51391,"compounds":"acetyl-CoA + dopamine <=> CoA + H(+) + N-acetyl-dopamine"}
{"X":43093,"RHEA_ID":41426,"compounds":"formate + grixazone A + H(+) + 3 H2O => 2 3-amino-4-hydroxybenzaldehyde + N-acetyl-L-cysteine + 2 O2"}
{"X":43094,"RHEA_ID":41427,"DIRECTION":"BI","MASTER_ID":41424,"metacyc":"RXN-15415","compounds":"2 3-amino-4-hydroxybenzaldehyde + N-acetyl-L-cysteine + 2 O2 <=> formate + grixazone A + H(+) + 3 H2O"}
{"X":43095,"RHEA_ID":41428,"DIRECTION":"UN","MASTER_ID":41428,"ec":"2.1.1.304","compounds":"L-tyrosine + S-adenosyl-L-methionine = 3-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine"}
{"X":43096,"RHEA_ID":51395,"compounds":"(9Z)-octadecenoyl-CoA + serotonin <=> CoA + H(+) + N-(9Z-octadecenoyl)-serotonin"}
{"X":43097,"RHEA_ID":41430,"compounds":"3-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine => L-tyrosine + S-adenosyl-L-methionine"}
{"X":43098,"RHEA_ID":41431,"compounds":"L-tyrosine + S-adenosyl-L-methionine <=> 3-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine"}
{"X":43099,"RHEA_ID":51398,"compounds":"CoA + H(+) + N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + serotonin"}
{"X":43100,"RHEA_ID":51399,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + serotonin <=> CoA + H(+) + N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin"}
{"X":43101,"RHEA_ID":51400,"compounds":"octadecanoyl-CoA + serotonin = CoA + H(+) + N-octadecanoyl-serotonin"}
{"X":43102,"RHEA_ID":51401,"compounds":"octadecanoyl-CoA + serotonin => CoA + H(+) + N-octadecanoyl-serotonin"}
{"X":43103,"RHEA_ID":51402,"compounds":"CoA + H(+) + N-octadecanoyl-serotonin => octadecanoyl-CoA + serotonin"}
{"X":43104,"RHEA_ID":51403,"compounds":"octadecanoyl-CoA + serotonin <=> CoA + H(+) + N-octadecanoyl-serotonin"}
{"X":43105,"RHEA_ID":51404,"DIRECTION":"UN","MASTER_ID":51404,"ec":"1.4.3.25","compounds":"H2O + L-arginine + O2 = 5-guanidino-2-oxopentanoate + H2O2 + NH4(+)"}
{"X":43106,"RHEA_ID":41439,"compounds":"(9Z)-octadecenoyl-CoA + cholesterol <=> cholesteryl (9Z-octadecenoate) + CoA"}
{"X":43107,"RHEA_ID":51406,"compounds":"5-guanidino-2-oxopentanoate + H2O2 + NH4(+) => H2O + L-arginine + O2"}
{"X":43108,"RHEA_ID":61740,"compounds":"steviolmonoside + UDP-alpha-D-glucose = H(+) + steviolbioside + UDP"}
{"X":43109,"RHEA_ID":51408,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}
{"X":43110,"RHEA_ID":51409,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}
{"X":43111,"RHEA_ID":51410,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H2O"}
{"X":43112,"RHEA_ID":51411,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}
{"X":43113,"RHEA_ID":51412,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = (8R)-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate"}
{"X":43114,"RHEA_ID":41448,"DIRECTION":"UN","MASTER_ID":41448,"ec":"1.14.11.45","compounds":"2-oxoglutarate + L-isoleucine + O2 = (4S)-4-hydroxy-L-isoleucine + CO2 + succinate"}
{"X":43115,"RHEA_ID":51415,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 <=> (8R)-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate"}
{"X":43116,"RHEA_ID":51416,"DIRECTION":"UN","MASTER_ID":51416,"ec":"1.3.1.112","compounds":"a (2S,3R)-flavan-3-ol + 2 NADP(+) = an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH"}
{"X":43117,"RHEA_ID":51417,"compounds":"a (2S,3R)-flavan-3-ol + 2 NADP(+) => an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH"}
{"X":43118,"RHEA_ID":51418,"DIRECTION":"RL","MASTER_ID":51416,"metacyc":"RXN-17716","compounds":"an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH => a (2S,3R)-flavan-3-ol + 2 NADP(+)"}
{"X":43119,"RHEA_ID":61752,"compounds":"steviolbioside + UDP-alpha-D-glucose = H(+) + rebaudioside B + UDP"}
{"X":43120,"RHEA_ID":51420,"DIRECTION":"UN","MASTER_ID":51420,"ec":"1.3.1.112","compounds":"a (2S,3S)-flavan-3-ol + 2 NADP(+) = an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH"}
{"X":43121,"RHEA_ID":51421,"compounds":"a (2S,3S)-flavan-3-ol + 2 NADP(+) => an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH"}
{"X":43122,"RHEA_ID":51422,"DIRECTION":"RL","MASTER_ID":51420,"metacyc":"RXN-17717","compounds":"an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH => a (2S,3S)-flavan-3-ol + 2 NADP(+)"}
{"X":43123,"RHEA_ID":41457,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + N-acylsphing-4-enine 1-phosphoethanolamine"}
{"X":43124,"RHEA_ID":41458,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + N-acylsphing-4-enine 1-phosphoethanolamine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine"}
{"X":43125,"RHEA_ID":41459,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + N-acylsphing-4-enine 1-phosphoethanolamine"}
{"X":43126,"RHEA_ID":51426,"compounds":"ADP + an N(4)-acetylcytidine in 18S rRNA + CoA + H(+) + phosphate => a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O"}
{"X":43127,"RHEA_ID":41461,"compounds":"1,2-diacyl-glycero-3-phosphocholine + an N-acylsphing-4-enine => a 1,2-diacylglycerol + sphingomyelin"}
{"X":43128,"RHEA_ID":41462,"compounds":"a 1,2-diacylglycerol + sphingomyelin => 1,2-diacyl-glycero-3-phosphocholine + an N-acylsphing-4-enine"}
{"X":43129,"RHEA_ID":41463,"compounds":"1,2-diacyl-glycero-3-phosphocholine + an N-acylsphing-4-enine <=> a 1,2-diacylglycerol + sphingomyelin"}
{"X":43130,"RHEA_ID":51430,"compounds":"2-N-acetamidomethylphosphonate + CoA => acetyl-CoA + aminomethylphosphonate"}
{"X":43131,"RHEA_ID":51431,"compounds":"acetyl-CoA + aminomethylphosphonate <=> 2-N-acetamidomethylphosphonate + CoA"}
{"X":43132,"RHEA_ID":51432,"compounds":"(S)-1-aminoethylphosphonate + acetyl-CoA = [(1S)-1-acetamidoethyl]phosphonate + CoA"}
{"X":43133,"RHEA_ID":51433,"DIRECTION":"LR","MASTER_ID":51432,"ecocyc":"RXN-17960","metacyc":"RXN-17960","compounds":"(S)-1-aminoethylphosphonate + acetyl-CoA => [(1S)-1-acetamidoethyl]phosphonate + CoA"}
{"X":43134,"RHEA_ID":41468,"DIRECTION":"UN","MASTER_ID":41468,"ec":"1.14.14.122","compounds":"ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oryzalexin E + oxidized [NADPH--hemoprotein reductase]"}
{"X":43135,"RHEA_ID":51435,"compounds":"(S)-1-aminoethylphosphonate + acetyl-CoA <=> [(1S)-1-acetamidoethyl]phosphonate + CoA"}
{"X":43136,"RHEA_ID":51436,"DIRECTION":"UN","MASTER_ID":51436,"ec":"2.3.1.263","compounds":"acetyl-CoA + D-alanine = (2R)-2-amino-4-oxopentanoate + CoA"}
{"X":43137,"RHEA_ID":51437,"compounds":"acetyl-CoA + D-alanine => (2R)-2-amino-4-oxopentanoate + CoA"}
{"X":43138,"RHEA_ID":41472,"DIRECTION":"UN","MASTER_ID":41472,"ec":"1.14.14.123","compounds":"ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oryzalexin D + oxidized [NADPH--hemoprotein reductase]"}
{"X":43139,"RHEA_ID":41473,"DIRECTION":"LR","MASTER_ID":41472,"metacyc":"RXN-15382","compounds":"ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oryzalexin D + oxidized [NADPH--hemoprotein reductase]"}
{"X":43140,"RHEA_ID":54758,"compounds":"AMP + 2 H(+) + pyridinium-3,5-dicarboxylate mononucleotide => deamido-NAD(+) + hydrogencarbonate"}
{"X":43141,"RHEA_ID":51441,"compounds":"(9Z,12Z,15Z)-octadecatrienoate + O2 => (11S)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate"}
{"X":43142,"RHEA_ID":41476,"compounds":"5alpha-cholesta-8,24-dien-3beta-ol + an acyl-CoA = CoA + zymosterol ester"}
{"X":43143,"RHEA_ID":41477,"compounds":"5alpha-cholesta-8,24-dien-3beta-ol + an acyl-CoA => CoA + zymosterol ester"}
{"X":43144,"RHEA_ID":44774,"compounds":"2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + H2O + NADP(+) => 2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + NADPH + O2"}
{"X":43145,"RHEA_ID":41479,"compounds":"5alpha-cholesta-8,24-dien-3beta-ol + an acyl-CoA <=> CoA + zymosterol ester"}
{"X":43146,"RHEA_ID":41480,"compounds":"an acyl-CoA + episterol = an episterol ester + CoA"}
{"X":43147,"RHEA_ID":41481,"compounds":"an acyl-CoA + episterol => an episterol ester + CoA"}
{"X":43148,"RHEA_ID":51448,"compounds":"chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase] = alpha-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43149,"RHEA_ID":41483,"compounds":"an acyl-CoA + episterol <=> an episterol ester + CoA"}
{"X":43150,"RHEA_ID":41484,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine"}
{"X":43151,"RHEA_ID":41485,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine"}
{"X":43152,"RHEA_ID":61785,"compounds":"L-allulose => keto-L-fructose"}
{"X":43153,"RHEA_ID":51453,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + ursodeoxycholate => beta-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43154,"RHEA_ID":41488,"compounds":"1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine"}
{"X":43155,"RHEA_ID":41489,"compounds":"1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine"}
{"X":43156,"RHEA_ID":61813,"compounds":"3beta-hydroxyandrost-5-en-17-one + UDP-alpha-D-glucose => dehydroepiandrosterone 3-beta-D-glucoside + H(+) + UDP"}
{"X":43157,"RHEA_ID":41491,"compounds":"1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine"}
{"X":43158,"RHEA_ID":41492,"compounds":"1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine"}
{"X":43159,"RHEA_ID":41493,"compounds":"1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine"}
{"X":43160,"RHEA_ID":61817,"compounds":"16,17-didehydropregnenolone + UDP-alpha-D-glucose => 16,17-didehydropregnenolone 3-beta-D-glucoside + H(+) + UDP"}
{"X":43161,"RHEA_ID":51461,"compounds":"H2O + N-(9Z-octadecenoyl)-L-glutamate => (9Z)-octadecenoate + L-glutamate"}
{"X":43162,"RHEA_ID":41496,"compounds":"1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine"}
{"X":43163,"RHEA_ID":41497,"compounds":"1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine => 1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine"}
{"X":43164,"RHEA_ID":61821,"compounds":"3beta-hydroxy-5alpha-androstan-17-one + UDP-alpha-D-glucose => epiandrosterone 3-beta-D-glucoside + H(+) + UDP"}
{"X":43165,"RHEA_ID":51465,"compounds":"deoxycholate + O2 + reduced [NADPH--hemoprotein reductase] => 1beta-hydroxydeoxycholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43166,"RHEA_ID":41500,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoserine + ethanolamine"}
{"X":43167,"RHEA_ID":41501,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + L-serine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoserine + ethanolamine"}
{"X":43168,"RHEA_ID":51468,"DIRECTION":"UN","MASTER_ID":51468,"ec":"1.1.5.12","compounds":"(R)-lactate + a quinone = a quinol + pyruvate"}
{"X":43169,"RHEA_ID":41503,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoserine + ethanolamine"}
{"X":43170,"RHEA_ID":41508,"DIRECTION":"UN","MASTER_ID":41508,"ec":"1.14.13.195","compounds":"L-ornithine + NADPH + O2 = H2O + N(5)-hydroxy-L-ornithine + NADP(+)"}
{"X":43171,"RHEA_ID":41508,"DIRECTION":"UN","MASTER_ID":41508,"ec":"1.14.13.196","compounds":"L-ornithine + NADPH + O2 = H2O + N(5)-hydroxy-L-ornithine + NADP(+)"}
{"X":43172,"RHEA_ID":51472,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43173,"RHEA_ID":51473,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43174,"RHEA_ID":41510,"compounds":"H2O + N(5)-hydroxy-L-ornithine + NADP(+) => L-ornithine + NADPH + O2"}
{"X":43175,"RHEA_ID":51475,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43176,"RHEA_ID":51476,"DIRECTION":"UN","MASTER_ID":51476,"ec":"1.1.98.6","compounds":"a ribonucleoside 5'-triphosphate + formate + H(+) = a 2'-deoxyribonucleoside 5'-triphosphate + CO2 + H2O"}
{"X":43177,"RHEA_ID":51477,"DIRECTION":"LR","MASTER_ID":51476,"ecocyc":"RIBONUCLEOSIDE-TRIP-REDUCT-RXN","metacyc":"RIBONUCLEOSIDE-TRIP-REDUCT-RXN","compounds":"a ribonucleoside 5'-triphosphate + formate + H(+) => a 2'-deoxyribonucleoside 5'-triphosphate + CO2 + H2O"}
{"X":43178,"RHEA_ID":41514,"compounds":"H2O + N(5)-hydroxy-L-ornithine + NAD(+) => L-ornithine + NADH + O2"}
{"X":43179,"RHEA_ID":51480,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43180,"RHEA_ID":51481,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43181,"RHEA_ID":41518,"compounds":"H(+) + H2O + omega-hydroxyphylloquinone + oxidized [NADPH--hemoprotein reductase] => O2 + phylloquinone + reduced [NADPH--hemoprotein reductase]"}
{"X":43182,"RHEA_ID":51483,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43183,"RHEA_ID":51484,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43184,"RHEA_ID":51485,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43185,"RHEA_ID":41522,"compounds":"H(+) + H2O + omega-hydroxymenaquinone-4 + oxidized [NADPH--hemoprotein reductase] => menaquinone-4 + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":43186,"RHEA_ID":41523,"compounds":"menaquinone-4 + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + omega-hydroxymenaquinone-4 + oxidized [NADPH--hemoprotein reductase]"}
{"X":43187,"RHEA_ID":61845,"DIRECTION":"LR","MASTER_ID":61844,"metacyc":"RXN-12123","compounds":"solasodine + UDP-alpha-D-glucose => H(+) + solasodine 3-beta-D-glucoside + UDP"}
{"X":43188,"RHEA_ID":51489,"DIRECTION":"LR","MASTER_ID":51488,"metacyc":"RXN-10935","compounds":"archaetidylserine + H(+) => archaetidylethanolamine + CO2"}
{"X":43189,"RHEA_ID":41526,"compounds":"5 CO2 + 5 CoA + H2O + naphthalene-1,3,6,8-tetrol => 5 H(+) + 5 malonyl-CoA"}
{"X":43190,"RHEA_ID":41527,"compounds":"5 H(+) + 5 malonyl-CoA <=> 5 CO2 + 5 CoA + H2O + naphthalene-1,3,6,8-tetrol"}
{"X":43191,"RHEA_ID":51492,"compounds":"all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-(4S)-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43192,"RHEA_ID":51493,"compounds":"all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-(4S)-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43193,"RHEA_ID":41530,"compounds":"NAD(+) + octanoyl-[ACP] => (2E)-octenoyl-[ACP] + H(+) + NADH"}
{"X":43194,"RHEA_ID":41531,"compounds":"(2E)-octenoyl-[ACP] + H(+) + NADH <=> NAD(+) + octanoyl-[ACP]"}
{"X":43195,"RHEA_ID":51496,"DIRECTION":"UN","MASTER_ID":51496,"ec":"2.7.1.91","compounds":"a sphingoid base + ATP = a sphingoid 1-phosphate + ADP + H(+)"}
{"X":43196,"RHEA_ID":51497,"DIRECTION":"LR","MASTER_ID":51496,"metacyc":"RXN-11376","compounds":"a sphingoid base + ATP => a sphingoid 1-phosphate + ADP + H(+)"}
{"X":43197,"RHEA_ID":41534,"compounds":"(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 3-hydroxy-L-phenylalanine => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2"}
{"X":43198,"RHEA_ID":61856,"compounds":"dehydroprobetaenone I + 3 H(+) + 3 NADPH + 3 O2 = betaenone C + 3 H2O + 3 NADP(+)"}
{"X":43199,"RHEA_ID":51500,"compounds":"ATP + N-acetyl-D-muramate = ADP + H(+) + N-acetyl-D-muramate 6-phosphate"}
{"X":43200,"RHEA_ID":51501,"compounds":"ATP + N-acetyl-D-muramate => ADP + H(+) + N-acetyl-D-muramate 6-phosphate"}
{"X":43201,"RHEA_ID":41538,"compounds":"2-hydroxy-7-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine => 2,7-dihydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine"}
{"X":43202,"RHEA_ID":51503,"compounds":"ATP + N-acetyl-D-muramate <=> ADP + H(+) + N-acetyl-D-muramate 6-phosphate"}
{"X":43203,"RHEA_ID":51504,"DIRECTION":"UN","MASTER_ID":51504,"ec":"2.4.1.360","compounds":"a 3'-hydro-2'-hydroxy-beta-oxodihydrochalcone + UDP-alpha-D-glucose = a 3'-(beta-D-glucopyranosyl)-2'-hydroxy-beta-oxodihydrochalcone + H(+) + UDP"}
{"X":43204,"RHEA_ID":51505,"DIRECTION":"LR","MASTER_ID":51504,"metacyc":"RXN-18732","compounds":"a 3'-hydro-2'-hydroxy-beta-oxodihydrochalcone + UDP-alpha-D-glucose => a 3'-(beta-D-glucopyranosyl)-2'-hydroxy-beta-oxodihydrochalcone + H(+) + UDP"}
{"X":43205,"RHEA_ID":41542,"compounds":"8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine => 8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + S-adenosyl-L-methionine"}
{"X":43206,"RHEA_ID":61864,"compounds":"AH2 + dehydroprobetaenone I = A + probetaenone I"}
{"X":43207,"RHEA_ID":51508,"DIRECTION":"UN","MASTER_ID":51508,"ec":"1.14.11.57","compounds":"2-oxoglutarate + L-proline + O2 = CO2 + succinate + trans-4-hydroxy-L-proline"}
{"X":43208,"RHEA_ID":51509,"DIRECTION":"LR","MASTER_ID":51508,"metacyc":"RXN490-3641","compounds":"2-oxoglutarate + L-proline + O2 => CO2 + succinate + trans-4-hydroxy-L-proline"}
{"X":43209,"RHEA_ID":41546,"compounds":"8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine => 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine"}
{"X":43210,"RHEA_ID":61868,"compounds":"1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl-(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatrienoate"}
{"X":43211,"RHEA_ID":51512,"DIRECTION":"UN","MASTER_ID":51512,"ec":"3.5.1.126","compounds":"H2O + oxamate = NH4(+) + oxalate"}
{"X":43212,"RHEA_ID":51513,"compounds":"H2O + oxamate => NH4(+) + oxalate"}
{"X":43213,"RHEA_ID":41550,"compounds":"8-demethyl-8-(2,3,4-tri-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine => 8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine"}
{"X":43214,"RHEA_ID":41552,"DIRECTION":"UN","MASTER_ID":41552,"ec":"4.2.3.145","compounds":"(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O = diphosphate + ophiobolin F"}
{"X":43215,"RHEA_ID":51517,"compounds":"(R)-reticuline + S-adenosyl-L-methionine => (R)-tembetarine + H(+) + S-adenosyl-L-homocysteine"}
{"X":43216,"RHEA_ID":51518,"compounds":"(R)-tembetarine + H(+) + S-adenosyl-L-homocysteine => (R)-reticuline + S-adenosyl-L-methionine"}
{"X":43217,"RHEA_ID":61876,"compounds":"1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl-8-hydroperoxy-20-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate"}
{"X":43218,"RHEA_ID":41556,"DIRECTION":"UN","MASTER_ID":41556,"ec":"1.14.11.47","compounds":"2-oxoglutarate + L-arginyl-[ribosomal protein uL16] + O2 = (3R)-3-hydroxy-L-arginyl-[ribosomal protein uL16] + CO2 + succinate"}
{"X":43219,"RHEA_ID":41557,"DIRECTION":"LR","MASTER_ID":41556,"ecocyc":"RXN0-7090","metacyc":"RXN0-7090","compounds":"2-oxoglutarate + L-arginyl-[ribosomal protein uL16] + O2 => (3R)-3-hydroxy-L-arginyl-[ribosomal protein uL16] + CO2 + succinate"}
{"X":43220,"RHEA_ID":51522,"compounds":"(S)-tembetarine + H(+) + S-adenosyl-L-homocysteine => (S)-reticuline + S-adenosyl-L-methionine"}
{"X":43221,"RHEA_ID":61880,"compounds":"1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl-12-hydroperoxy-20-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate"}
{"X":43222,"RHEA_ID":41560,"DIRECTION":"UN","MASTER_ID":41560,"ec":"1.14.14.15","compounds":"(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FADH2 + O2 = (3S)-3-amino-3-(3-chloro-4,5-dihydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FAD + H(+) + H2O"}
{"X":43223,"RHEA_ID":41561,"DIRECTION":"LR","MASTER_ID":41560,"metacyc":"RXN-15398","compounds":"(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FADH2 + O2 => (3S)-3-amino-3-(3-chloro-4,5-dihydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FAD + H(+) + H2O"}
{"X":43224,"RHEA_ID":61883,"compounds":"1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl-12-hydroperoxy-20-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate"}
{"X":43225,"RHEA_ID":61884,"compounds":"1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl-9-hydroperoxy-20-hydroxy-(5Z,7E,11Z,14Z)-eicosatetraenoate"}
{"X":43226,"RHEA_ID":41564,"DIRECTION":"UN","MASTER_ID":41564,"ec":"2.4.1.326","compounds":"aklavinone + dTDP-beta-L-rhodosamine = aclacinomycin T + dTDP + 2 H(+)"}
{"X":43227,"RHEA_ID":41565,"DIRECTION":"LR","MASTER_ID":41564,"metacyc":"RXN-14853","compounds":"aklavinone + dTDP-beta-L-rhodosamine => aclacinomycin T + dTDP + 2 H(+)"}
{"X":43228,"RHEA_ID":41566,"compounds":"aclacinomycin T + dTDP + 2 H(+) => aklavinone + dTDP-beta-L-rhodosamine"}
{"X":43229,"RHEA_ID":51531,"compounds":"4-hydroxy-3-methoxybenzoate + H(+) <=> CO2 + guaiacol"}
{"X":43230,"RHEA_ID":41568,"DIRECTION":"UN","MASTER_ID":41568,"ec":"2.4.1.327","compounds":"aclacinomycin T + dTDP-2-deoxy-beta-L-fucose = aclacinomycin S + dTDP + H(+)"}
{"X":43231,"RHEA_ID":41569,"DIRECTION":"LR","MASTER_ID":41568,"metacyc":"RXN-14852","compounds":"aclacinomycin T + dTDP-2-deoxy-beta-L-fucose => aclacinomycin S + dTDP + H(+)"}
{"X":43232,"RHEA_ID":61891,"compounds":"diosgenin + UDP-alpha-D-glucose <=> diosgenin 3-beta-D-glucoside + H(+) + UDP"}
{"X":43233,"RHEA_ID":61896,"compounds":"betaenone C = betaenone A"}
{"X":43234,"RHEA_ID":41572,"compounds":"lipoxin A4 + NAD(+) = 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH"}
{"X":43235,"RHEA_ID":41573,"DIRECTION":"LR","MASTER_ID":41572,"reactome":"R-HSA-2161779.3","compounds":"lipoxin A4 + NAD(+) => 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH"}
{"X":43236,"RHEA_ID":51538,"compounds":"H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-L-tyrosyl-[protein] + UDP => L-tyrosyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":43237,"RHEA_ID":51539,"compounds":"L-tyrosyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-L-tyrosyl-[protein] + UDP"}
{"X":43238,"RHEA_ID":41576,"DIRECTION":"UN","MASTER_ID":41576,"ec":"2.4.1.328","compounds":"dTDP-beta-L-mycarose + erythronolide B = 3-O-alpha-L-mycarosylerythronolide B + dTDP + H(+)"}
{"X":43239,"RHEA_ID":41577,"compounds":"dTDP-beta-L-mycarose + erythronolide B => 3-O-alpha-L-mycarosylerythronolide B + dTDP + H(+)"}
{"X":43240,"RHEA_ID":51542,"compounds":"(S)-corytuberine + 2 H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":43241,"RHEA_ID":51543,"compounds":"(S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-corytuberine + 2 H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43242,"RHEA_ID":51544,"DIRECTION":"UN","MASTER_ID":51544,"ec":"5.1.3.31","compounds":"D-ribulose = D-xylulose"}
{"X":43243,"RHEA_ID":41581,"compounds":"5,10-dihydrophenazine 1-carboxylate + dimethylallyl diphosphate => 5,10-dihydro-9-dimethylallylphenazine 1-carboxylate + diphosphate"}
{"X":43244,"RHEA_ID":51546,"compounds":"D-xylulose => D-ribulose"}
{"X":43245,"RHEA_ID":51547,"compounds":"D-ribulose <=> D-xylulose"}
{"X":43246,"RHEA_ID":51548,"DIRECTION":"UN","MASTER_ID":51548,"ec":"2.1.1.337","compounds":"(R)-tetrahydropapaverine + S-adenosyl-L-methionine = (R)-N-methyltetrahydropapaverine + H(+) + S-adenosyl-L-homocysteine"}
{"X":43247,"RHEA_ID":41585,"compounds":"dimethylallyl diphosphate + L-tyrosine => 4-O-dimethylallyl-L-tyrosine + diphosphate"}
{"X":43248,"RHEA_ID":41586,"compounds":"4-O-dimethylallyl-L-tyrosine + diphosphate => dimethylallyl diphosphate + L-tyrosine"}
{"X":43249,"RHEA_ID":41587,"DIRECTION":"BI","MASTER_ID":41584,"metacyc":"RXN-15419","compounds":"dimethylallyl diphosphate + L-tyrosine <=> 4-O-dimethylallyl-L-tyrosine + diphosphate"}
{"X":43250,"RHEA_ID":51552,"compounds":"D-sorbitol + NADP(+) = H(+) + L-xylo-3-hexulose + NADPH"}
{"X":43251,"RHEA_ID":41589,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + choline + H(+)"}
{"X":43252,"RHEA_ID":51554,"compounds":"H(+) + L-xylo-3-hexulose + NADPH => D-sorbitol + NADP(+)"}
{"X":43253,"RHEA_ID":51555,"DIRECTION":"BI","MASTER_ID":51552,"metacyc":"RXN-12080","compounds":"D-sorbitol + NADP(+) <=> H(+) + L-xylo-3-hexulose + NADPH"}
{"X":43254,"RHEA_ID":51556,"DIRECTION":"UN","MASTER_ID":51556,"ec":"2.1.1.337","compounds":"(S)-glaucine + S-adenosyl-L-methionine = (S)-N-methylglaucine + H(+) + S-adenosyl-L-homocysteine"}
{"X":43255,"RHEA_ID":41593,"compounds":"15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH => 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)"}
{"X":43256,"RHEA_ID":51558,"compounds":"(S)-N-methylglaucine + H(+) + S-adenosyl-L-homocysteine => (S)-glaucine + S-adenosyl-L-methionine"}
{"X":43257,"RHEA_ID":51559,"compounds":"(S)-glaucine + S-adenosyl-L-methionine <=> (S)-N-methylglaucine + H(+) + S-adenosyl-L-homocysteine"}
{"X":43258,"RHEA_ID":51560,"DIRECTION":"UN","MASTER_ID":51560,"ec":"2.1.1.337","compounds":"(S)-bulbocapnine + S-adenosyl-L-methionine = (S)-N-methylbulbocapnine + H(+) + S-adenosyl-L-homocysteine"}
{"X":43259,"RHEA_ID":41597,"compounds":"15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + H(+) + NADH => (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)"}
{"X":43260,"RHEA_ID":51562,"compounds":"(S)-N-methylbulbocapnine + H(+) + S-adenosyl-L-homocysteine => (S)-bulbocapnine + S-adenosyl-L-methionine"}
{"X":43261,"RHEA_ID":51563,"compounds":"(S)-bulbocapnine + S-adenosyl-L-methionine <=> (S)-N-methylbulbocapnine + H(+) + S-adenosyl-L-homocysteine"}
{"X":43262,"RHEA_ID":51564,"DIRECTION":"UN","MASTER_ID":51564,"ec":"1.14.15.29","compounds":"cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] = (25S)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":43263,"RHEA_ID":41601,"compounds":"1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine => 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine"}
{"X":43264,"RHEA_ID":51566,"compounds":"(25S)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]"}
{"X":43265,"RHEA_ID":61928,"compounds":"(R)-miconazole(in) + ATP + H2O = (R)-miconazole(out) + ADP + H(+) + phosphate"}
{"X":43266,"RHEA_ID":51568,"compounds":"(25S)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (25S)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":43267,"RHEA_ID":41605,"compounds":"1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + L-serine => 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine"}
{"X":43268,"RHEA_ID":51570,"compounds":"(25S)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (25S)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":43269,"RHEA_ID":41607,"compounds":"1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine"}
{"X":43270,"RHEA_ID":51572,"compounds":"(25S)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (25S)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":43271,"RHEA_ID":41609,"DIRECTION":"LR","MASTER_ID":41608,"metacyc":"RXN-15426","compounds":"3'-phosphoadenylyl sulfate + alpha,alpha-trehalose => 2-O-sulfo-alpha,alpha-trehalose + adenosine 3',5'-bisphosphate + H(+)"}
{"X":43272,"RHEA_ID":51574,"compounds":"(25S)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (25S)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":43273,"RHEA_ID":44906,"compounds":"alpha-D-glucose + phosphate => alpha-D-glucose 6-phosphate + H2O"}
{"X":43274,"RHEA_ID":41612,"DIRECTION":"UN","MASTER_ID":41612,"ec":"3.1.4.57","compounds":"alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O = D-ribose 2,5-bisphosphate + H(+)"}
{"X":43275,"RHEA_ID":51577,"DIRECTION":"LR","MASTER_ID":51576,"metacyc":"RXN-11465","compounds":"phloretin + UDP-alpha-D-glucose => H(+) + phlorizin + UDP"}
{"X":43276,"RHEA_ID":51578,"compounds":"H(+) + phlorizin + UDP => phloretin + UDP-alpha-D-glucose"}
{"X":43277,"RHEA_ID":61940,"compounds":"3beta-hydroxy-16alpha,17alpha-epoxypregnenolone + UDP-alpha-D-glucose = 3beta-hydroxy-16alpha,17alpha-epoxypregnenolone 3-beta-D-glucoside + H(+) + UDP"}
{"X":43278,"RHEA_ID":41616,"DIRECTION":"UN","MASTER_ID":41616,"ec":"3.1.4.57","compounds":"D-ribose 2,5-bisphosphate + H2O = D-ribose 5-phosphate + phosphate"}
{"X":43279,"RHEA_ID":51581,"compounds":"a fatty acid(out) + ATP(in) + CoA(in) + H(+)(out) => AMP(in) + an acyl-CoA(in) + diphosphate(in) + H(+)(in)"}
{"X":43280,"RHEA_ID":51582,"compounds":"AMP(in) + an acyl-CoA(in) + diphosphate(in) + H(+)(in) => a fatty acid(out) + ATP(in) + CoA(in) + H(+)(out)"}
{"X":43281,"RHEA_ID":41619,"compounds":"D-ribose 2,5-bisphosphate + H2O <=> D-ribose 5-phosphate + phosphate"}
{"X":43282,"RHEA_ID":51584,"DIRECTION":"UN","MASTER_ID":51584,"ec":"1.3.8.13","compounds":"gamma-butyrobetainyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = crotonobetainyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":43283,"RHEA_ID":41625,"DIRECTION":"LR","MASTER_ID":41624,"metacyc":"RXN-15362","compounds":"3-sulfinopropanoyl-CoA + H2O => H(+) + propanoyl-CoA + sulfite"}
{"X":43284,"RHEA_ID":51586,"DIRECTION":"RL","MASTER_ID":51584,"ecocyc":"CROBETREDUCT-RXN","metacyc":"CROBETREDUCT-RXN","compounds":"crotonobetainyl-CoA + reduced [electron-transfer flavoprotein] => gamma-butyrobetainyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":43285,"RHEA_ID":51587,"DIRECTION":"BI","MASTER_ID":51584,"ecocyc":"CROBETREDUCT-RXN","compounds":"gamma-butyrobetainyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> crotonobetainyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":43286,"RHEA_ID":41628,"DIRECTION":"UN","MASTER_ID":41628,"ec":"4.2.3.146","compounds":"geranylgeranyl diphosphate + H2O = cyclooctat-9-en-7-ol + diphosphate"}
{"X":43287,"RHEA_ID":51589,"DIRECTION":"LR","MASTER_ID":51588,"metacyc":"RXN-19621","compounds":"isopyridoxal + NAD(+) => 5-pyridoxolactone + H(+) + NADH"}
{"X":43288,"RHEA_ID":51590,"compounds":"5-pyridoxolactone + H(+) + NADH => isopyridoxal + NAD(+)"}
{"X":43289,"RHEA_ID":51591,"compounds":"isopyridoxal + NAD(+) <=> 5-pyridoxolactone + H(+) + NADH"}
{"X":43290,"RHEA_ID":51592,"DIRECTION":"UN","MASTER_ID":51592,"ec":"1.14.15.26","compounds":"2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + toluene = benzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":43291,"RHEA_ID":51593,"DIRECTION":"LR","MASTER_ID":51592,"metacyc":"TOLUENE-SIDE-CHAIN-MONOOXYGENASE-RXN","compounds":"2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + toluene => benzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":43292,"RHEA_ID":51594,"compounds":"benzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + toluene"}
{"X":43293,"RHEA_ID":41635,"compounds":"1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phospho-L-serine + ethanolamine"}
{"X":43294,"RHEA_ID":51596,"DIRECTION":"UN","MASTER_ID":51596,"ec":"1.14.15.26","compounds":"2 H(+) + O2 + p-xylene + 2 reduced [2Fe-2S]-[ferredoxin] = 4-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":43295,"RHEA_ID":41637,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + H2O => 1-O-(1Z-alkenyl)-sn-glycerol + phosphate"}
{"X":43296,"RHEA_ID":41638,"compounds":"1-O-(1Z-alkenyl)-sn-glycerol + phosphate => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + H2O"}
{"X":43297,"RHEA_ID":41639,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + H2O <=> 1-O-(1Z-alkenyl)-sn-glycerol + phosphate"}
{"X":43298,"RHEA_ID":41640,"DIRECTION":"UN","MASTER_ID":41640,"ec":"6.2.1.41","compounds":"3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA = 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate"}
{"X":43299,"RHEA_ID":51601,"DIRECTION":"LR","MASTER_ID":51600,"metacyc":"RXN-8578","compounds":"2 H(+) + m-xylene + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":43300,"RHEA_ID":41642,"compounds":"3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate => 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA"}
{"X":43301,"RHEA_ID":61964,"compounds":"a 1-O-octadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + AH2 + O2 = A + a 1-O-(1Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 H2O"}
{"X":43302,"RHEA_ID":41644,"DIRECTION":"UN","MASTER_ID":41644,"ec":"6.2.1.43","compounds":"2-hydroxy-7-methoxy-5-methyl-1-naphthoate + ATP + CoA = 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA + AMP + diphosphate"}
{"X":43303,"RHEA_ID":51605,"DIRECTION":"LR","MASTER_ID":51604,"metacyc":"RXN-661","compounds":"2 H(+) + O2 + p-cymene + 2 reduced [2Fe-2S]-[ferredoxin] => 4-isopropylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":43304,"RHEA_ID":41646,"compounds":"2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA + AMP + diphosphate => 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + ATP + CoA"}
{"X":43305,"RHEA_ID":61968,"compounds":"a 1-O-(9Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + AH2 + O2 = A + a 1-O-(1Z,9Z-octadecadienyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 H2O"}
{"X":43306,"RHEA_ID":41648,"DIRECTION":"UN","MASTER_ID":41648,"ec":"6.3.1.18","compounds":"aniline + ATP + L-glutamate = ADP + N(5)-phenyl-L-glutamine + phosphate"}
{"X":43307,"RHEA_ID":41649,"DIRECTION":"LR","MASTER_ID":41648,"metacyc":"RXN-14637","compounds":"aniline + ATP + L-glutamate => ADP + N(5)-phenyl-L-glutamine + phosphate"}
{"X":43308,"RHEA_ID":51610,"compounds":"(R)-lactate + 2-oxoglutarate => (R)-2-hydroxyglutarate + pyruvate"}
{"X":43309,"RHEA_ID":41651,"compounds":"aniline + ATP + L-glutamate <=> ADP + N(5)-phenyl-L-glutamine + phosphate"}
{"X":43310,"RHEA_ID":41652,"DIRECTION":"UN","MASTER_ID":41652,"ec":"2.4.1.327","compounds":"aclacinomycin S + dTDP-2-deoxy-beta-L-fucose = 2-deoxy-alpha-L-fucosylaclacinomycin S + dTDP + H(+)"}
{"X":43311,"RHEA_ID":41653,"DIRECTION":"LR","MASTER_ID":41652,"metacyc":"RXN-14852","compounds":"aclacinomycin S + dTDP-2-deoxy-beta-L-fucose => 2-deoxy-alpha-L-fucosylaclacinomycin S + dTDP + H(+)"}
{"X":43312,"RHEA_ID":51614,"compounds":"(R)-malate + 2-oxoglutarate => (R)-2-hydroxyglutarate + oxaloacetate"}
{"X":43313,"RHEA_ID":41655,"compounds":"aclacinomycin S + dTDP-2-deoxy-beta-L-fucose <=> 2-deoxy-alpha-L-fucosylaclacinomycin S + dTDP + H(+)"}
{"X":43314,"RHEA_ID":41656,"DIRECTION":"UN","MASTER_ID":41656,"ec":"1.3.1.107","compounds":"dihydrosanguinarine + NADP(+) = NADPH + sanguinarine"}
{"X":43315,"RHEA_ID":41657,"compounds":"dihydrosanguinarine + NADP(+) => NADPH + sanguinarine"}
{"X":43316,"RHEA_ID":61979,"compounds":"glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin]"}
{"X":43317,"RHEA_ID":44954,"compounds":"NADP(+) + octanoyl-CoA => (2E)-octenoyl-CoA + H(+) + NADPH"}
{"X":43318,"RHEA_ID":41660,"DIRECTION":"UN","MASTER_ID":41660,"ec":"1.3.1.107","compounds":"dihydrosanguinarine + NAD(+) = NADH + sanguinarine"}
{"X":43319,"RHEA_ID":41661,"compounds":"dihydrosanguinarine + NAD(+) => NADH + sanguinarine"}
{"X":43320,"RHEA_ID":51622,"compounds":"CO2 + dCTP + H2O => CTP + formate + H(+)"}
{"X":43321,"RHEA_ID":44958,"compounds":"hexanoyl-CoA + NADP(+) => (2E)-hexenoyl-CoA + H(+) + NADPH"}
{"X":43322,"RHEA_ID":41664,"DIRECTION":"UN","MASTER_ID":41664,"ec":"1.3.1.107","compounds":"dihydrochelirubine + NAD(+) = chelirubine + NADH"}
{"X":43323,"RHEA_ID":41665,"compounds":"dihydrochelirubine + NAD(+) => chelirubine + NADH"}
{"X":43324,"RHEA_ID":61987,"compounds":"H(+) + NADH + ubiquinone-10 <=> NAD(+) + ubiquinol-10"}
{"X":43325,"RHEA_ID":61988,"compounds":"cytidine(72) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(72) in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":43326,"RHEA_ID":41668,"DIRECTION":"UN","MASTER_ID":41668,"ec":"1.3.1.107","compounds":"dihydrochelirubine + NADP(+) = chelirubine + NADPH"}
{"X":43327,"RHEA_ID":41669,"compounds":"dihydrochelirubine + NADP(+) => chelirubine + NADPH"}
{"X":43328,"RHEA_ID":61991,"compounds":"cytidine(72) in tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(72) in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":43329,"RHEA_ID":44966,"compounds":"dodecanoyl-CoA + NADP(+) => (2E)-dodecenoyl-CoA + H(+) + NADPH"}
{"X":43330,"RHEA_ID":41672,"compounds":"1-O-hexadecyl-sn-glycerol + ATP = 1-O-hexadecyl-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":43331,"RHEA_ID":41673,"compounds":"1-O-hexadecyl-sn-glycerol + ATP => 1-O-hexadecyl-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":43332,"RHEA_ID":61995,"compounds":"N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine"}
{"X":43333,"RHEA_ID":51635,"compounds":"all-trans-(4S)-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-(4S,16)-dihydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43334,"RHEA_ID":41676,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycerol + ATP = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":43335,"RHEA_ID":41677,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycerol + ATP => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":43336,"RHEA_ID":61999,"compounds":"L-lysyl-[protein] + lactoyl-CoA <=> CoA + H(+) + N(6)-lactoyl-L-lysyl-[protein]"}
{"X":43337,"RHEA_ID":51639,"compounds":"a quinone + H2O + selenite <=> a quinol + selenate"}
{"X":43338,"RHEA_ID":41680,"DIRECTION":"UN","MASTER_ID":41680,"ec":"4.1.1.98","compounds":"a 4-hydroxy-3-all-trans-polyprenylbenzoate + H(+) = a 2-all-trans-polyprenylphenol + CO2"}
{"X":43339,"RHEA_ID":41681,"compounds":"a 4-hydroxy-3-all-trans-polyprenylbenzoate + H(+) => a 2-all-trans-polyprenylphenol + CO2"}
{"X":43340,"RHEA_ID":62003,"compounds":"3 A + protoporphyrinogen IX <=> 3 AH2 + protoporphyrin IX"}
{"X":43341,"RHEA_ID":41684,"compounds":"1-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine + H2O = 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate + choline + H(+)"}
{"X":43342,"RHEA_ID":41685,"compounds":"1-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine + H2O => 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate + choline + H(+)"}
{"X":43343,"RHEA_ID":62007,"compounds":"an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc6S derivative + GDP-beta-L-fucose <=> an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc6S derivative + GDP + H(+)"}
{"X":43344,"RHEA_ID":41687,"compounds":"1-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine + H2O <=> 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate + choline + H(+)"}
{"X":43345,"RHEA_ID":41688,"compounds":"1-O-hexadecyl-2-propanoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + propanoate"}
{"X":43346,"RHEA_ID":51649,"DIRECTION":"LR","MASTER_ID":51648,"metacyc":"RXN-18454","compounds":"H2O + N(6)-acetyl-L-lysyl-[protein] + O2 => [protein]-(S)-2-amino-6-oxohexanoate + acetamide + H2O2"}
{"X":43347,"RHEA_ID":62011,"compounds":"alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose <=> alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP + H(+)"}
{"X":43348,"RHEA_ID":41691,"compounds":"1-O-hexadecyl-2-propanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + propanoate"}
{"X":43349,"RHEA_ID":41692,"compounds":"1-O-hexadecyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + butanoate + H(+)"}
{"X":43350,"RHEA_ID":51653,"compounds":"D-mannonate + NAD(+) => H(+) + keto-D-tagaturonate + NADH"}
{"X":43351,"RHEA_ID":62015,"compounds":"cytidine(2499) in 23S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(2499) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":43352,"RHEA_ID":41695,"compounds":"1-O-hexadecyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + butanoate + H(+)"}
{"X":43353,"RHEA_ID":41696,"compounds":"1-O-hexadecyl-2-succinyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + succinate"}
{"X":43354,"RHEA_ID":41697,"compounds":"1-O-hexadecyl-2-succinyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + succinate"}
{"X":43355,"RHEA_ID":62019,"compounds":"L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose <=> 3-O-(beta-D-xylosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP"}
{"X":43356,"RHEA_ID":41699,"compounds":"1-O-hexadecyl-2-succinyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + succinate"}
{"X":43357,"RHEA_ID":41700,"compounds":"1-O-hexadecyl-2-glutaryl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + glutarate + H(+)"}
{"X":43358,"RHEA_ID":51661,"compounds":"an N-(1,2-saturated acyl)sphinganine + H(+) + NADPH + O2 => an N-(2-hydroxyacyl)-sphinganine + H2O + NADP(+)"}
{"X":43359,"RHEA_ID":51662,"compounds":"an N-(2-hydroxyacyl)-sphinganine + H2O + NADP(+) => an N-(1,2-saturated acyl)sphinganine + H(+) + NADPH + O2"}
{"X":43360,"RHEA_ID":41703,"compounds":"1-O-hexadecyl-2-glutaryl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + glutarate + H(+)"}
{"X":43361,"RHEA_ID":41704,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + acetate + H(+)"}
{"X":43362,"RHEA_ID":51665,"DIRECTION":"LR","MASTER_ID":51664,"ecocyc":"RXN0-275","metacyc":"RXN0-275","compounds":"D-5-phenylhydantoin + H2O => H(+) + N-carbamoyl-D-phenylglycine"}
{"X":43363,"RHEA_ID":62027,"compounds":"campesteryl 3-beta-D-glucoside + H2O <=> campesterol + D-glucose"}
{"X":43364,"RHEA_ID":41707,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphate + acetate + H(+)"}
{"X":43365,"RHEA_ID":41708,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphoethanolamine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphoethanolamine + acetate + H(+)"}
{"X":43366,"RHEA_ID":51669,"compounds":"H(+) + mevastatin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2 oxidized [2Fe-2S]-[ferredoxin] + pravastatin"}
{"X":43367,"RHEA_ID":51670,"compounds":"2 oxidized [2Fe-2S]-[ferredoxin] + pravastatin => H(+) + mevastatin + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":43368,"RHEA_ID":41711,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphoethanolamine + acetate + H(+)"}
{"X":43369,"RHEA_ID":51672,"compounds":"glyoxal + H2O = glycolate + H(+)"}
{"X":43370,"RHEA_ID":41713,"compounds":"a 2-acyl-sn-glycero-3-phosphocholine + H2O => a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)"}
{"X":43371,"RHEA_ID":51674,"compounds":"glycolate + H(+) => glyoxal + H2O"}
{"X":43372,"RHEA_ID":41715,"compounds":"a 2-acyl-sn-glycero-3-phosphocholine + H2O <=> a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)"}
{"X":43373,"RHEA_ID":41716,"compounds":"a 2-acyl-sn-glycero-3-phospho-L-serine + H2O = a 2-acyl-sn-glycerol 3-phosphate + H(+) + L-serine"}
{"X":43374,"RHEA_ID":62038,"compounds":"a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+) => a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O"}
{"X":43375,"RHEA_ID":51678,"compounds":"[protein]-dithiol + 2 AH2 + H(+) + sulfite => [protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide"}
{"X":43376,"RHEA_ID":41719,"compounds":"a 2-acyl-sn-glycero-3-phospho-L-serine + H2O <=> a 2-acyl-sn-glycerol 3-phosphate + H(+) + L-serine"}
{"X":43377,"RHEA_ID":41720,"compounds":"a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":43378,"RHEA_ID":62042,"compounds":"N-octanoylsphing-4-enine + phosphate => H2O + N-(octanoyl)-sphing-4-enine-1-phosphate"}
{"X":43379,"RHEA_ID":41722,"compounds":"(9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphocholine + H(+) => a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O"}
{"X":43380,"RHEA_ID":41723,"compounds":"a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":43381,"RHEA_ID":41724,"compounds":"dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = (11R)-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43382,"RHEA_ID":51685,"DIRECTION":"LR","MASTER_ID":51684,"metacyc":"RXN-11626","compounds":"(2E,6E)-farnesyl phosphate + CTP => (2E,6E)-farnesyl diphosphate + CDP"}
{"X":43383,"RHEA_ID":41726,"compounds":"(11R)-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":43384,"RHEA_ID":41727,"compounds":"dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (11R)-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43385,"RHEA_ID":41728,"DIRECTION":"UN","MASTER_ID":41728,"ec":"1.14.14.80","compounds":"(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43386,"RHEA_ID":51689,"compounds":"galactitol + NAD(+) => H(+) + keto-L-tagatose + NADH"}
{"X":43387,"RHEA_ID":51690,"compounds":"H(+) + keto-L-tagatose + NADH => galactitol + NAD(+)"}
{"X":43388,"RHEA_ID":62052,"compounds":"a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphate + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)"}
{"X":43389,"RHEA_ID":41732,"DIRECTION":"UN","MASTER_ID":41732,"ec":"2.4.1.1","compounds":"[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate"}
{"X":43390,"RHEA_ID":51693,"DIRECTION":"LR","MASTER_ID":51692,"ecocyc":"RXN0-7066","metacyc":"RXN0-7066","compounds":"prephenate + S-adenosyl-L-methionine => 3-phenylpyruvate + carboxy-S-adenosyl-L-methionine + H2O"}
{"X":43391,"RHEA_ID":51694,"compounds":"3-phenylpyruvate + carboxy-S-adenosyl-L-methionine + H2O => prephenate + S-adenosyl-L-methionine"}
{"X":43392,"RHEA_ID":51697,"DIRECTION":"LR","MASTER_ID":51696,"metacyc":"RXN-7821","compounds":"desmethylxanthohumol + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + xanthohumol"}
{"X":43393,"RHEA_ID":41737,"compounds":"3'-phosphoadenylyl sulfate + a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) => adenosine 3',5'-bisphosphate + beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+)"}
{"X":43394,"RHEA_ID":41738,"compounds":"adenosine 3',5'-bisphosphate + beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+) => 3'-phosphoadenylyl sulfate + a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))"}
{"X":43395,"RHEA_ID":41739,"compounds":"3'-phosphoadenylyl sulfate + a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) <=> adenosine 3',5'-bisphosphate + beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+)"}
{"X":43396,"RHEA_ID":51701,"compounds":"S-adenosyl-L-methionine + xanthogalenol => 4'-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine"}
{"X":43397,"RHEA_ID":51702,"compounds":"4'-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + xanthogalenol"}
{"X":43398,"RHEA_ID":41742,"compounds":"2 H(+) + N(1)-methyladenosine(57)/N(1)-methyladenosine(58) in tRNA + 2 S-adenosyl-L-homocysteine => adenosine(57)/adenosine(58) in tRNA + 2 S-adenosyl-L-methionine"}
{"X":43399,"RHEA_ID":41743,"compounds":"adenosine(57)/adenosine(58) in tRNA + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(1)-methyladenosine(57)/N(1)-methyladenosine(58) in tRNA + 2 S-adenosyl-L-homocysteine"}
{"X":43400,"RHEA_ID":41744,"DIRECTION":"UN","MASTER_ID":41744,"ec":"2.8.2.11","compounds":"3'-phosphoadenylyl sulfate + a 1-O-alkyl-2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol = a 1-O-alkyl-2-acyl-3-(beta-D-3-sulfogalactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+)"}
{"X":43401,"RHEA_ID":62067,"compounds":"2-deoxy-D-glucose 6-phosphate + NAD(+) <=> 2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADH"}
{"X":43402,"RHEA_ID":41746,"compounds":"a 1-O-alkyl-2-acyl-3-(beta-D-3-sulfogalactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + a 1-O-alkyl-2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol"}
{"X":43403,"RHEA_ID":41747,"compounds":"3'-phosphoadenylyl sulfate + a 1-O-alkyl-2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol <=> a 1-O-alkyl-2-acyl-3-(beta-D-3-sulfogalactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+)"}
{"X":43404,"RHEA_ID":41748,"compounds":"3'-phosphoadenylyl sulfate + a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol = 3-O-sulfo-beta-D-galactosyl-diacylglycerol + adenosine 3',5'-bisphosphate + H(+)"}
{"X":43405,"RHEA_ID":51710,"compounds":"H(+) + keto-D-tagatose + NADH => D-altritol + NAD(+)"}
{"X":43406,"RHEA_ID":41750,"compounds":"3-O-sulfo-beta-D-galactosyl-diacylglycerol + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol"}
{"X":43407,"RHEA_ID":41752,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H(+)"}
{"X":43408,"RHEA_ID":62075,"compounds":"D-galactose 6-phosphate + NADP(+) <=> 6-phospho-D-galactono-1,5-lactone + H(+) + NADPH"}
{"X":43409,"RHEA_ID":41754,"compounds":"(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O"}
{"X":43410,"RHEA_ID":41756,"compounds":"1-O-methyl-(9Z,12Z)-octadecadienoate + O2 = 1-O-methyl-(13S)-hydroperoxy-(9Z,11E)-octadecadienoate"}
{"X":43411,"RHEA_ID":62079,"compounds":"D-galactose 6-phosphate + NAD(+) <=> 6-phospho-D-galactono-1,5-lactone + H(+) + NADH"}
{"X":43412,"RHEA_ID":41758,"compounds":"1-O-methyl-(13S)-hydroperoxy-(9Z,11E)-octadecadienoate => 1-O-methyl-(9Z,12Z)-octadecadienoate + O2"}
{"X":43413,"RHEA_ID":41759,"compounds":"1-O-methyl-(9Z,12Z)-octadecadienoate + O2 <=> 1-O-methyl-(13S)-hydroperoxy-(9Z,11E)-octadecadienoate"}
{"X":43414,"RHEA_ID":41760,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GM3 (d18:1(4E)) = CMP + ganglioside GD3 (d18:1(4E)) + H(+)"}
{"X":43415,"RHEA_ID":62083,"compounds":"D-glucose 6-sulfate + NADP(+) <=> 6-sulfo-D-glucono-1,5-lactone + H(+) + NADPH"}
{"X":43416,"RHEA_ID":41762,"compounds":"CMP + ganglioside GD3 (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM3 (d18:1(4E))"}
{"X":43417,"RHEA_ID":41763,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GM3 (d18:1(4E)) <=> CMP + ganglioside GD3 (d18:1(4E)) + H(+)"}
{"X":43418,"RHEA_ID":41764,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GD3 (d18:1(4E)) = CMP + ganglioside GT3 (d18:1(4E)) + H(+)"}
{"X":43419,"RHEA_ID":51726,"compounds":"adenosine 5'-tetraphosphate + ADP + 2 H(+) => H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate"}
{"X":43420,"RHEA_ID":41766,"compounds":"CMP + ganglioside GT3 (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GD3 (d18:1(4E))"}
{"X":43421,"RHEA_ID":41767,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GD3 (d18:1(4E)) <=> CMP + ganglioside GT3 (d18:1(4E)) + H(+)"}
{"X":43422,"RHEA_ID":41768,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GD1a (18:1(4E)) = CMP + ganglioside GT1a (d18:1(4E)) + H(+)"}
{"X":43423,"RHEA_ID":62091,"compounds":"D-glucosamine 6-phosphate + NADP(+) <=> 2-amino-2-deoxy-6-phospho-D-glucono-1,5-lactone + 2 H(+) + NADPH"}
{"X":43424,"RHEA_ID":41771,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GD1a (18:1(4E)) <=> CMP + ganglioside GT1a (d18:1(4E)) + H(+)"}
{"X":43425,"RHEA_ID":41772,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GT1b (d18:1(4E)) = CMP + ganglioside GQ1b (d18:1(4E)) + H(+)"}
{"X":43426,"RHEA_ID":51734,"compounds":"H(+) + meleagrin + S-adenosyl-L-homocysteine => glandicoline B + S-adenosyl-L-methionine"}
{"X":43427,"RHEA_ID":51735,"compounds":"glandicoline B + S-adenosyl-L-methionine <=> H(+) + meleagrin + S-adenosyl-L-homocysteine"}
{"X":43428,"RHEA_ID":41775,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GT1b (d18:1(4E)) <=> CMP + ganglioside GQ1b (d18:1(4E)) + H(+)"}
{"X":43429,"RHEA_ID":41776,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E)/18:0) = CMP + ganglioside GM2 (d18:1(4E)/18:0) + H(+)"}
{"X":43430,"RHEA_ID":62099,"compounds":"2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 2-(9Z-octadecenoyl)-glycerol + phosphate"}
{"X":43431,"RHEA_ID":62100,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate"}
{"X":43432,"RHEA_ID":41779,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E)/18:0) <=> CMP + ganglioside GM2 (d18:1(4E)/18:0) + H(+)"}
{"X":43433,"RHEA_ID":41780,"compounds":"a D-galactosylceramide + CMP-N-acetyl-beta-neuraminate = CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-D-galactosylceramide"}
{"X":43434,"RHEA_ID":51742,"compounds":"a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A"}
{"X":43435,"RHEA_ID":51743,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A <=> a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate)"}
{"X":43436,"RHEA_ID":41783,"compounds":"a D-galactosylceramide + CMP-N-acetyl-beta-neuraminate <=> CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-D-galactosylceramide"}
{"X":43437,"RHEA_ID":41784,"compounds":"asialo-GM1a ganglioside (d18:1(4E)/18:0) + CMP-N-acetyl-beta-neuraminate = CMP + ganglioside GM1 (d18:1(4E)/18:0) + H(+)"}
{"X":43438,"RHEA_ID":51746,"compounds":"a 1,2-diacyl-sn-glycerol + lipid A 1-(2-aminoethyl diphosphate) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A"}
{"X":43439,"RHEA_ID":62108,"compounds":"an acyl-CoA + sn-glycero-3-phosphoethanolamine = a monoacyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":43440,"RHEA_ID":41787,"compounds":"asialo-GM1a ganglioside (d18:1(4E)/18:0) + CMP-N-acetyl-beta-neuraminate <=> CMP + ganglioside GM1 (d18:1(4E)/18:0) + H(+)"}
{"X":43441,"RHEA_ID":41788,"DIRECTION":"UN","MASTER_ID":41788,"ec":"2.3.1.38","compounds":"acetyl-CoA + holo-[ACP] = acetyl-[ACP] + CoA"}
{"X":43442,"RHEA_ID":51750,"compounds":"4-amino-4-deoxy-beta-L-arabinopyranosyl-lipid A + di-trans,octa-cis-undecaprenyl phosphate => 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A"}
{"X":43443,"RHEA_ID":51751,"compounds":"4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A <=> 4-amino-4-deoxy-beta-L-arabinopyranosyl-lipid A + di-trans,octa-cis-undecaprenyl phosphate"}
{"X":43444,"RHEA_ID":51752,"DIRECTION":"UN","MASTER_ID":51752,"ec":"2.5.1.136","compounds":"a 2-acylphloroglucinol + dimethylallyl diphosphate = a 2-acyl-4-prenylphloroglucinol + diphosphate"}
{"X":43445,"RHEA_ID":41792,"DIRECTION":"UN","MASTER_ID":41792,"ec":"2.3.1.39","compounds":"holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP]"}
{"X":43446,"RHEA_ID":51754,"compounds":"a 2-acyl-4-prenylphloroglucinol + diphosphate => a 2-acylphloroglucinol + dimethylallyl diphosphate"}
{"X":43447,"RHEA_ID":51756,"DIRECTION":"UN","MASTER_ID":51756,"ec":"2.5.1.137","compounds":"a 2-acyl-4-prenylphloroglucinol + dimethylallyl diphosphate = a 2-acyl-4,6-diprenylphloroglucinol + diphosphate"}
{"X":43448,"RHEA_ID":51757,"DIRECTION":"LR","MASTER_ID":51756,"metacyc":"RXN-18444","compounds":"a 2-acyl-4-prenylphloroglucinol + dimethylallyl diphosphate => a 2-acyl-4,6-diprenylphloroglucinol + diphosphate"}
{"X":43449,"RHEA_ID":51758,"compounds":"a 2-acyl-4,6-diprenylphloroglucinol + diphosphate => a 2-acyl-4-prenylphloroglucinol + dimethylallyl diphosphate"}
{"X":43450,"RHEA_ID":41799,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoylsphinganine <=> a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphocholine"}
{"X":43451,"RHEA_ID":51761,"DIRECTION":"LR","MASTER_ID":51760,"metacyc":"RXN-18451","compounds":"a 2-acyl-4,6-diprenylphloroglucinol + dimethylallyl diphosphate => a 2-acyl-4,6,6-triprenylphloroglucinol + diphosphate"}
{"X":43452,"RHEA_ID":51762,"compounds":"a 2-acyl-4,6,6-triprenylphloroglucinol + diphosphate => a 2-acyl-4,6-diprenylphloroglucinol + dimethylallyl diphosphate"}
{"X":43453,"RHEA_ID":41803,"compounds":"acetyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxobutanoyl-[ACP] + CO2 + holo-[ACP]"}
{"X":43454,"RHEA_ID":51765,"DIRECTION":"LR","MASTER_ID":51764,"metacyc":"RXN-7811","compounds":"dimethylallyl diphosphate + phlorisovalerophenone => 4-prenylphlorisovalerophenone + diphosphate"}
{"X":43455,"RHEA_ID":51766,"compounds":"4-prenylphlorisovalerophenone + diphosphate => dimethylallyl diphosphate + phlorisovalerophenone"}
{"X":43456,"RHEA_ID":41806,"compounds":"(3R)-hydroxybutanoyl-[ACP] + NADP(+) => 3-oxobutanoyl-[ACP] + H(+) + NADPH"}
{"X":43457,"RHEA_ID":51768,"DIRECTION":"UN","MASTER_ID":51768,"ec":"2.5.1.136","compounds":"2-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one + dimethylallyl diphosphate = 4-prenylphlormethylbutanophenone + diphosphate"}
{"X":43458,"RHEA_ID":41808,"compounds":"(3R)-hydroxybutanoyl-[ACP] = (2E)-butenoyl-[ACP] + H2O"}
{"X":43459,"RHEA_ID":51770,"compounds":"4-prenylphlormethylbutanophenone + diphosphate => 2-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one + dimethylallyl diphosphate"}
{"X":43460,"RHEA_ID":41810,"compounds":"(2E)-butenoyl-[ACP] + H2O => (3R)-hydroxybutanoyl-[ACP]"}
{"X":43461,"RHEA_ID":51772,"DIRECTION":"UN","MASTER_ID":51772,"ec":"2.5.1.136","compounds":"2-methyl-1-(2,4,6-trihydroxyphenyl)propan-1-one + dimethylallyl diphosphate = 4-prenylphlorisobutanophenone + diphosphate"}
{"X":43462,"RHEA_ID":51773,"DIRECTION":"LR","MASTER_ID":51772,"metacyc":"RXN-7812","compounds":"2-methyl-1-(2,4,6-trihydroxyphenyl)propan-1-one + dimethylallyl diphosphate => 4-prenylphlorisobutanophenone + diphosphate"}
{"X":43463,"RHEA_ID":51774,"compounds":"4-prenylphlorisobutanophenone + diphosphate => 2-methyl-1-(2,4,6-trihydroxyphenyl)propan-1-one + dimethylallyl diphosphate"}
{"X":43464,"RHEA_ID":41814,"compounds":"butanoyl-[ACP] + NADP(+) => (2E)-butenoyl-[ACP] + H(+) + NADPH"}
{"X":43465,"RHEA_ID":41815,"compounds":"(2E)-butenoyl-[ACP] + H(+) + NADPH <=> butanoyl-[ACP] + NADP(+)"}
{"X":43466,"RHEA_ID":41816,"compounds":"ganglioside GD3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = ganglioside GD2 (d18:1(4E)) + H(+) + UDP"}
{"X":43467,"RHEA_ID":62143,"compounds":"dTMP + GTP <=> dTDP + GDP"}
{"X":43468,"RHEA_ID":41818,"compounds":"ganglioside GD2 (d18:1(4E)) + H(+) + UDP => ganglioside GD3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine"}
{"X":43469,"RHEA_ID":51780,"DIRECTION":"UN","MASTER_ID":51780,"ec":"2.5.1.137","compounds":"4-prenylphlormethylbutanophenone + dimethylallyl diphosphate = deoxyadlupulone + diphosphate"}
{"X":43470,"RHEA_ID":41820,"compounds":"butanoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxohexanoyl-[ACP] + CO2 + holo-[ACP]"}
{"X":43471,"RHEA_ID":62147,"compounds":"dGMP + dGTP <=> 2 dGDP"}
{"X":43472,"RHEA_ID":41822,"compounds":"3-oxohexanoyl-[ACP] + CO2 + holo-[ACP] => butanoyl-[ACP] + H(+) + malonyl-[ACP]"}
{"X":43473,"RHEA_ID":51784,"DIRECTION":"UN","MASTER_ID":51784,"ec":"2.5.1.137","compounds":"4-prenylphlorisovalerophenone + dimethylallyl diphosphate = deoxyhumulone + diphosphate"}
{"X":43474,"RHEA_ID":41824,"compounds":"3-oxohexanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyhexanoyl-[ACP] + NADP(+)"}
{"X":43475,"RHEA_ID":62151,"compounds":"dGTP + dTMP <=> dGDP + dTDP"}
{"X":43476,"RHEA_ID":41826,"compounds":"(3R)-hydroxyhexanoyl-[ACP] + NADP(+) => 3-oxohexanoyl-[ACP] + H(+) + NADPH"}
{"X":43477,"RHEA_ID":51788,"compounds":"2-hydroxybenzoyl-5'-AMP + CoA = 2-hydroxybenzoyl-CoA + AMP + H(+)"}
{"X":43478,"RHEA_ID":41828,"compounds":"(3R)-hydroxyhexanoyl-[ACP] = (2E)-hexenoyl-[ACP] + H2O"}
{"X":43479,"RHEA_ID":41829,"compounds":"(3R)-hydroxyhexanoyl-[ACP] => (2E)-hexenoyl-[ACP] + H2O"}
{"X":43480,"RHEA_ID":51791,"compounds":"2-hydroxybenzoyl-5'-AMP + CoA <=> 2-hydroxybenzoyl-CoA + AMP + H(+)"}
{"X":43481,"RHEA_ID":51792,"compounds":"H(+) + NADH + O2 + salicylate = 2,3-dihydroxybenzoate + H2O + NAD(+)"}
{"X":43482,"RHEA_ID":41832,"compounds":"(2E)-hexenoyl-[ACP] + H(+) + NADPH = hexanoyl-[ACP] + NADP(+)"}
{"X":43483,"RHEA_ID":51794,"compounds":"2,3-dihydroxybenzoate + H2O + NAD(+) => H(+) + NADH + O2 + salicylate"}
{"X":43484,"RHEA_ID":51795,"compounds":"H(+) + NADH + O2 + salicylate <=> 2,3-dihydroxybenzoate + H2O + NAD(+)"}
{"X":43485,"RHEA_ID":41835,"compounds":"(2E)-hexenoyl-[ACP] + H(+) + NADPH <=> hexanoyl-[ACP] + NADP(+)"}
{"X":43486,"RHEA_ID":41836,"compounds":"H(+) + hexanoyl-[ACP] + malonyl-[ACP] = 3-oxooctanoyl-[ACP] + CO2 + holo-[ACP]"}
{"X":43487,"RHEA_ID":51798,"compounds":"colupulone + diphosphate + H(+) => deoxycohumulone + dimethylallyl diphosphate"}
{"X":43488,"RHEA_ID":51799,"compounds":"deoxycohumulone + dimethylallyl diphosphate <=> colupulone + diphosphate + H(+)"}
{"X":43489,"RHEA_ID":51800,"DIRECTION":"UN","MASTER_ID":51800,"ec":"2.5.1.137","compounds":"deoxyadlupulone + dimethylallyl diphosphate = adlupulone + diphosphate + H(+)"}
{"X":43490,"RHEA_ID":41840,"compounds":"3-oxooctanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyoctanoyl-[ACP] + NADP(+)"}
{"X":43491,"RHEA_ID":51802,"compounds":"adlupulone + diphosphate + H(+) => deoxyadlupulone + dimethylallyl diphosphate"}
{"X":43492,"RHEA_ID":51803,"compounds":"deoxyadlupulone + dimethylallyl diphosphate <=> adlupulone + diphosphate + H(+)"}
{"X":43493,"RHEA_ID":51804,"DIRECTION":"UN","MASTER_ID":51804,"ec":"2.5.1.137","compounds":"deoxyhumulone + dimethylallyl diphosphate = diphosphate + H(+) + lupulone"}
{"X":43494,"RHEA_ID":41844,"compounds":"(3R)-hydroxyoctanoyl-[ACP] = (2E)-octenoyl-[ACP] + H2O"}
{"X":43495,"RHEA_ID":51806,"compounds":"diphosphate + H(+) + lupulone => deoxyhumulone + dimethylallyl diphosphate"}
{"X":43496,"RHEA_ID":41846,"compounds":"(2E)-octenoyl-[ACP] + H2O => (3R)-hydroxyoctanoyl-[ACP]"}
{"X":43497,"RHEA_ID":51808,"compounds":"(9Z)-octadecenoate(out) + ATP(in) + CoA(in) + H(+)(out) = (9Z)-octadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)"}
{"X":43498,"RHEA_ID":41848,"compounds":"(2E)-octenoyl-[ACP] + H(+) + NADPH = NADP(+) + octanoyl-[ACP]"}
{"X":43499,"RHEA_ID":51810,"compounds":"(9Z)-octadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in) => (9Z)-octadecenoate(out) + ATP(in) + CoA(in) + H(+)(out)"}
{"X":43500,"RHEA_ID":51811,"compounds":"(9Z)-octadecenoate(out) + ATP(in) + CoA(in) + H(+)(out) <=> (9Z)-octadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)"}
{"X":43501,"RHEA_ID":41851,"compounds":"(2E)-octenoyl-[ACP] + H(+) + NADPH <=> NADP(+) + octanoyl-[ACP]"}
{"X":43502,"RHEA_ID":41852,"compounds":"H(+) + malonyl-[ACP] + octanoyl-[ACP] = 3-oxodecanoyl-[ACP] + CO2 + holo-[ACP]"}
{"X":43503,"RHEA_ID":51814,"compounds":"AMP(in) + diphosphate(in) + H(+)(in) + tetradecanoyl-CoA(in) => ATP(in) + CoA(in) + H(+)(out) + tetradecanoate(out)"}
{"X":43504,"RHEA_ID":45150,"compounds":"3-hydroxy-3-(methylsulfanyl)propanoyl-CoA => 3-(methylsulfanyl)acryloyl-CoA + H2O"}
{"X":43505,"RHEA_ID":41855,"compounds":"H(+) + malonyl-[ACP] + octanoyl-[ACP] <=> 3-oxodecanoyl-[ACP] + CO2 + holo-[ACP]"}
{"X":43506,"RHEA_ID":41856,"compounds":"3-oxodecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxydecanoyl-[ACP] + NADP(+)"}
{"X":43507,"RHEA_ID":51818,"compounds":"AMP(in) + diphosphate(in) + dodecanoyl-CoA(in) + H(+)(in) => ATP(in) + CoA(in) + dodecanoate(out) + H(+)(out)"}
{"X":43508,"RHEA_ID":45154,"compounds":"3-oxopropanoyl-CoA + methanethiol => 3-hydroxy-3-(methylsulfanyl)propanoyl-CoA"}
{"X":43509,"RHEA_ID":51820,"compounds":"ATP(in) + CoA(in) + decanoate(out) + H(+)(out) = AMP(in) + decanoyl-CoA(in) + diphosphate(in) + H(+)(in)"}
{"X":43510,"RHEA_ID":41860,"compounds":"(3R)-hydroxydecanoyl-[ACP] = (2E)-decenoyl-[ACP] + H2O"}
{"X":43511,"RHEA_ID":51822,"compounds":"AMP(in) + decanoyl-CoA(in) + diphosphate(in) + H(+)(in) => ATP(in) + CoA(in) + decanoate(out) + H(+)(out)"}
{"X":43512,"RHEA_ID":51823,"compounds":"ATP(in) + CoA(in) + decanoate(out) + H(+)(out) <=> AMP(in) + decanoyl-CoA(in) + diphosphate(in) + H(+)(in)"}
{"X":43513,"RHEA_ID":41863,"compounds":"(3R)-hydroxydecanoyl-[ACP] <=> (2E)-decenoyl-[ACP] + H2O"}
{"X":43514,"RHEA_ID":41864,"compounds":"(2E)-decenoyl-[ACP] + H(+) + NADPH = decanoyl-[ACP] + NADP(+)"}
{"X":43515,"RHEA_ID":51826,"compounds":"AMP(in) + diphosphate(in) + H(+)(in) + octanoyl-CoA(in) => ATP(in) + CoA(in) + H(+)(out) + octanoate(out)"}
{"X":43516,"RHEA_ID":51827,"compounds":"ATP(in) + CoA(in) + H(+)(out) + octanoate(out) <=> AMP(in) + diphosphate(in) + H(+)(in) + octanoyl-CoA(in)"}
{"X":43517,"RHEA_ID":51828,"compounds":"ATP(in) + CoA(in) + docosanoate(out) + H(+)(out) = AMP(in) + diphosphate(in) + docosanoyl-CoA(in) + H(+)(in)"}
{"X":43518,"RHEA_ID":41868,"compounds":"decanoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxododecanoyl-[ACP] + CO2 + holo-[ACP]"}
{"X":43519,"RHEA_ID":51830,"compounds":"AMP(in) + diphosphate(in) + docosanoyl-CoA(in) + H(+)(in) => ATP(in) + CoA(in) + docosanoate(out) + H(+)(out)"}
{"X":43520,"RHEA_ID":41870,"compounds":"3-oxododecanoyl-[ACP] + CO2 + holo-[ACP] => decanoyl-[ACP] + H(+) + malonyl-[ACP]"}
{"X":43521,"RHEA_ID":51832,"compounds":"ATP(in) + CoA(in) + H(+)(out) + tetracosanoate(out) = AMP(in) + diphosphate(in) + H(+)(in) + tetracosanoyl-CoA(in)"}
{"X":43522,"RHEA_ID":41872,"compounds":"3-oxododecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxydodecanoyl-[ACP] + NADP(+)"}
{"X":43523,"RHEA_ID":41873,"compounds":"3-oxododecanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxydodecanoyl-[ACP] + NADP(+)"}
{"X":43524,"RHEA_ID":51835,"compounds":"ATP(in) + CoA(in) + H(+)(out) + tetracosanoate(out) <=> AMP(in) + diphosphate(in) + H(+)(in) + tetracosanoyl-CoA(in)"}
{"X":43525,"RHEA_ID":51836,"compounds":"(9Z)-tetradecenoate(out) + ATP(in) + CoA(in) + H(+)(out) = (9Z)-tetradecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)"}
{"X":43526,"RHEA_ID":41876,"compounds":"(3R)-hydroxydodecanoyl-[ACP] = (2E)-dodecenoyl-[ACP] + H2O"}
{"X":43527,"RHEA_ID":41877,"compounds":"(3R)-hydroxydodecanoyl-[ACP] => (2E)-dodecenoyl-[ACP] + H2O"}
{"X":43528,"RHEA_ID":51839,"compounds":"(9Z)-tetradecenoate(out) + ATP(in) + CoA(in) + H(+)(out) <=> (9Z)-tetradecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)"}
{"X":43529,"RHEA_ID":51844,"compounds":"(9Z)-hexadecenoate(out) + ATP(in) + CoA(in) + H(+)(out) = (9Z)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)"}
{"X":43530,"RHEA_ID":41880,"compounds":"(2E)-dodecenoyl-[ACP] + H(+) + NADPH = dodecanoyl-[ACP] + NADP(+)"}
{"X":43531,"RHEA_ID":51846,"compounds":"(9Z)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in) => (9Z)-hexadecenoate(out) + ATP(in) + CoA(in) + H(+)(out)"}
{"X":43532,"RHEA_ID":51847,"compounds":"(9Z)-hexadecenoate(out) + ATP(in) + CoA(in) + H(+)(out) <=> (9Z)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)"}
{"X":43533,"RHEA_ID":51848,"compounds":"8-methylmenaquinone-6 + succinate = 8-methylmenaquinol-6 + fumarate"}
{"X":43534,"RHEA_ID":41884,"compounds":"dodecanoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxotetradecanoyl-[ACP] + CO2 + holo-[ACP]"}
{"X":43535,"RHEA_ID":51850,"compounds":"8-methylmenaquinol-6 + fumarate => 8-methylmenaquinone-6 + succinate"}
{"X":43536,"RHEA_ID":45182,"compounds":"2 CoA + 2 H(+) + N(1),N(8)-bis(coumaroyl)-spermidine => 2 (E)-4-coumaroyl-CoA + spermidine"}
{"X":43537,"RHEA_ID":51852,"compounds":"(9Z,12Z)-octadecadienoate(out) + ATP(in) + CoA(in) + H(+)(out) = (9Z,12Z)-octadecadienoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)"}
{"X":43538,"RHEA_ID":41888,"compounds":"3-oxotetradecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxytetradecanoyl-[ACP] + NADP(+)"}
{"X":43539,"RHEA_ID":51854,"compounds":"(9Z,12Z)-octadecadienoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in) => (9Z,12Z)-octadecadienoate(out) + ATP(in) + CoA(in) + H(+)(out)"}
{"X":43540,"RHEA_ID":41890,"compounds":"(3R)-hydroxytetradecanoyl-[ACP] + NADP(+) => 3-oxotetradecanoyl-[ACP] + H(+) + NADPH"}
{"X":43541,"RHEA_ID":51856,"compounds":"(E)-hexadec-2-enoate(out) + ATP(in) + CoA(in) + H(+)(out) = (2E)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)"}
{"X":43542,"RHEA_ID":41892,"compounds":"(3R)-hydroxytetradecanoyl-[ACP] = (2E)-tetradecenoyl-[ACP] + H2O"}
{"X":43543,"RHEA_ID":51858,"compounds":"(2E)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in) => (E)-hexadec-2-enoate(out) + ATP(in) + CoA(in) + H(+)(out)"}
{"X":43544,"RHEA_ID":51859,"compounds":"(E)-hexadec-2-enoate(out) + ATP(in) + CoA(in) + H(+)(out) <=> (2E)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)"}
{"X":43545,"RHEA_ID":51860,"DIRECTION":"UN","MASTER_ID":51860,"ec":"2.5.1.138","compounds":"(2E)-geranyl diphosphate + umbelliferone = 8-geranylumbelliferone + diphosphate"}
{"X":43546,"RHEA_ID":41896,"compounds":"(2E)-tetradecenoyl-[ACP] + H(+) + NADPH = NADP(+) + tetradecanoyl-[ACP]"}
{"X":43547,"RHEA_ID":51862,"compounds":"8-geranylumbelliferone + diphosphate => (2E)-geranyl diphosphate + umbelliferone"}
{"X":43548,"RHEA_ID":62228,"compounds":"(E)-ascladiol + A = AH2 + patulin"}
{"X":43549,"RHEA_ID":51864,"DIRECTION":"UN","MASTER_ID":51864,"ec":"2.5.1.138","compounds":"(2E)-geranyl diphosphate + esculetin = 8-geranylesculetin + diphosphate"}
{"X":43550,"RHEA_ID":41900,"compounds":"H(+) + malonyl-[ACP] + tetradecanoyl-[ACP] = 3-oxohexadecanoyl-[ACP] + CO2 + holo-[ACP]"}
{"X":43551,"RHEA_ID":51866,"compounds":"8-geranylesculetin + diphosphate => (2E)-geranyl diphosphate + esculetin"}
{"X":43552,"RHEA_ID":62232,"DIRECTION":"UN","MASTER_ID":62232,"ec":"4.1.99.13","compounds":"a thymidine(6-4)thymidine in DNA = a thymidine dimer in DNA"}
{"X":43553,"RHEA_ID":51868,"DIRECTION":"UN","MASTER_ID":51868,"ec":"2.5.1.139","compounds":"dimethylallyl diphosphate + umbelliferone = demethylsuberosin + diphosphate"}
{"X":43554,"RHEA_ID":41904,"compounds":"3-oxohexadecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyhexadecanoyl-[ACP] + NADP(+)"}
{"X":43555,"RHEA_ID":51870,"compounds":"demethylsuberosin + diphosphate => dimethylallyl diphosphate + umbelliferone"}
{"X":43556,"RHEA_ID":62236,"DIRECTION":"UN","MASTER_ID":62236,"ec":"4.1.99.13","compounds":"a cytidine(6-4)cytidine in DNA = a cytidine dimer in DNA + H(+)"}
{"X":43557,"RHEA_ID":41907,"compounds":"3-oxohexadecanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxyhexadecanoyl-[ACP] + NADP(+)"}
{"X":43558,"RHEA_ID":41908,"compounds":"(3R)-hydroxyhexadecanoyl-[ACP] = (2E)-hexadecenoyl-[ACP] + H2O"}
{"X":43559,"RHEA_ID":51874,"compounds":"diphosphate + osthenol => dimethylallyl diphosphate + umbelliferone"}
{"X":43560,"RHEA_ID":51875,"compounds":"dimethylallyl diphosphate + umbelliferone <=> diphosphate + osthenol"}
{"X":43561,"RHEA_ID":41911,"compounds":"(3R)-hydroxyhexadecanoyl-[ACP] <=> (2E)-hexadecenoyl-[ACP] + H2O"}
{"X":43562,"RHEA_ID":41912,"compounds":"(2E)-hexadecenoyl-[ACP] + H(+) + NADPH = hexadecanoyl-[ACP] + NADP(+)"}
{"X":43563,"RHEA_ID":51878,"compounds":"desmethylxanthohumol + diphosphate => 2',4,4',6'-tetrahydroxychalcone + dimethylallyl diphosphate"}
{"X":43564,"RHEA_ID":51879,"compounds":"2',4,4',6'-tetrahydroxychalcone + dimethylallyl diphosphate <=> desmethylxanthohumol + diphosphate"}
{"X":43565,"RHEA_ID":51880,"compounds":"3,4,6-trichlorocatechol + O2 = (2Z,4E)-2,3,5-trichloromuconate + H(+)"}
{"X":43566,"RHEA_ID":41916,"compounds":"H(+) + hexadecanoyl-[ACP] + malonyl-[ACP] = 3-oxooctadecanoyl-[ACP] + CO2 + holo-[ACP]"}
{"X":43567,"RHEA_ID":51882,"compounds":"(2Z,4E)-2,3,5-trichloromuconate + H(+) => 3,4,6-trichlorocatechol + O2"}
{"X":43568,"RHEA_ID":41918,"compounds":"3-oxooctadecanoyl-[ACP] + CO2 + holo-[ACP] => H(+) + hexadecanoyl-[ACP] + malonyl-[ACP]"}
{"X":43569,"RHEA_ID":41919,"compounds":"H(+) + hexadecanoyl-[ACP] + malonyl-[ACP] <=> 3-oxooctadecanoyl-[ACP] + CO2 + holo-[ACP]"}
{"X":43570,"RHEA_ID":41920,"compounds":"3-oxooctadecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyoctadecanoyl-[ACP] + NADP(+)"}
{"X":43571,"RHEA_ID":51886,"compounds":"D-proline betaine => L-proline betaine"}
{"X":43572,"RHEA_ID":62252,"compounds":"2 hydrogencarbonate(out) + Zn(2+)(out) = 2 hydrogencarbonate(in) + Zn(2+)(in)"}
{"X":43573,"RHEA_ID":51888,"DIRECTION":"UN","MASTER_ID":51888,"ec":"1.1.1.404","compounds":"2,3,5,6-tetrachlorohydroquinone + H(+) + NAD(+) = 2,3,5,6-tetrachloro-1,4-benzoquinone + NADH"}
{"X":43574,"RHEA_ID":41924,"compounds":"(3R)-hydroxyoctadecanoyl-[ACP] = (2E)-octadecenoyl-[ACP] + H2O"}
{"X":43575,"RHEA_ID":51890,"DIRECTION":"RL","MASTER_ID":51888,"metacyc":"RXN-18404","compounds":"2,3,5,6-tetrachloro-1,4-benzoquinone + NADH => 2,3,5,6-tetrachlorohydroquinone + H(+) + NAD(+)"}
{"X":43576,"RHEA_ID":62256,"compounds":"Cd(2+)(out) + 2 hydrogencarbonate(out) = Cd(2+)(in) + 2 hydrogencarbonate(in)"}
{"X":43577,"RHEA_ID":51892,"compounds":"H2O + N-acetylcadaverine = acetate + cadaverine"}
{"X":43578,"RHEA_ID":41928,"compounds":"(2E)-octadecenoyl-[ACP] + H(+) + NADPH = NADP(+) + octadecanoyl-[ACP]"}
{"X":43579,"RHEA_ID":51894,"compounds":"acetate + cadaverine => H2O + N-acetylcadaverine"}
{"X":43580,"RHEA_ID":41930,"compounds":"NADP(+) + octadecanoyl-[ACP] => (2E)-octadecenoyl-[ACP] + H(+) + NADPH"}
{"X":43581,"RHEA_ID":51896,"compounds":"H2O + N(1)-acetylspermine = acetate + spermine"}
{"X":43582,"RHEA_ID":41932,"DIRECTION":"UN","MASTER_ID":41932,"ec":"3.1.2.14","compounds":"H2O + hexadecanoyl-[ACP] = H(+) + hexadecanoate + holo-[ACP]"}
{"X":43583,"RHEA_ID":51898,"compounds":"acetate + spermine => H2O + N(1)-acetylspermine"}
{"X":43584,"RHEA_ID":41934,"compounds":"H(+) + hexadecanoate + holo-[ACP] => H2O + hexadecanoyl-[ACP]"}
{"X":43585,"RHEA_ID":62265,"compounds":"hydrogencarbonate(out) + selenite(out) + Zn(2+)(out) => hydrogencarbonate(in) + selenite(in) + Zn(2+)(in)"}
{"X":43586,"RHEA_ID":41936,"compounds":"a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + UDP-alpha-D-galactose = a neolactoside IV(3)-beta-[Gal-beta-(1->3)-GlcNAc]-nLc4Cer(d18:1(4E)) + H(+) + UDP"}
{"X":43587,"RHEA_ID":51902,"compounds":"acetate + spermidine => H2O + N(1)-acetylspermidine"}
{"X":43588,"RHEA_ID":41938,"compounds":"a neolactoside IV(3)-beta-[Gal-beta-(1->3)-GlcNAc]-nLc4Cer(d18:1(4E)) + H(+) + UDP => a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + UDP-alpha-D-galactose"}
{"X":43589,"RHEA_ID":62269,"compounds":"(R)-2-hydroxy-3-methylbutyrate + NADP(+) => 3-methyl-2-oxobutanoate + H(+) + NADPH"}
{"X":43590,"RHEA_ID":41940,"DIRECTION":"UN","MASTER_ID":41940,"ec":"6.3.2.43","compounds":"[amino group carrier protein]-C-terminal-L-glutamate + ATP + L-2-aminoadipate = [amino group carrier protein]-C-terminal-N-(1,5-dicarboxypentan-1-yl)-L-glutamine + ADP + H(+) + phosphate"}
{"X":43591,"RHEA_ID":51906,"compounds":"10-formyltetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate => 10-formyltetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate"}
{"X":43592,"RHEA_ID":41942,"compounds":"[amino group carrier protein]-C-terminal-N-(1,5-dicarboxypentan-1-yl)-L-glutamine + ADP + H(+) + phosphate => [amino group carrier protein]-C-terminal-L-glutamate + ATP + L-2-aminoadipate"}
{"X":43593,"RHEA_ID":55222,"compounds":"3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate + 6 [Fe(III)-cytochrome b5] + 4 H2O => 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2"}
{"X":43594,"RHEA_ID":41944,"compounds":"[amino group carrier protein]-C-terminal-N-(1,5-dicarboxypentan-1-yl)-L-glutamine + ATP = [amino group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + ADP"}
{"X":43595,"RHEA_ID":51910,"compounds":"dADP + H(+) + phosphate => dATP + H2O"}
{"X":43596,"RHEA_ID":41946,"compounds":"[amino group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + ADP => [amino group carrier protein]-C-terminal-N-(1,5-dicarboxypentan-1-yl)-L-glutamine + ATP"}
{"X":43597,"RHEA_ID":55226,"compounds":"4beta-hydroxymethyl-4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O => 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}
{"X":43598,"RHEA_ID":41948,"DIRECTION":"UN","MASTER_ID":41948,"ec":"1.2.1.103","compounds":"[amino group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + NADP(+) + phosphate = [amino group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + H(+) + NADPH"}
{"X":43599,"RHEA_ID":41949,"compounds":"[amino group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + NADP(+) + phosphate => [amino group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + H(+) + NADPH"}
{"X":43600,"RHEA_ID":41950,"DIRECTION":"RL","MASTER_ID":41948,"metacyc":"RXN-5183","compounds":"[amino group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + H(+) + NADPH => [amino group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + NADP(+) + phosphate"}
{"X":43601,"RHEA_ID":51916,"compounds":"(2S)-2-amino-3-butenoate + H2O = 2-oxobutanoate + NH4(+)"}
{"X":43602,"RHEA_ID":41952,"DIRECTION":"UN","MASTER_ID":41952,"ec":"2.6.1.118","compounds":"2-oxoglutarate + [amino group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate = [amino group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamate"}
{"X":43603,"RHEA_ID":51918,"compounds":"2-oxobutanoate + NH4(+) => (2S)-2-amino-3-butenoate + H2O"}
{"X":43604,"RHEA_ID":41954,"compounds":"[amino group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamate => 2-oxoglutarate + [amino group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate"}
{"X":43605,"RHEA_ID":48550,"compounds":"[phosphatase 2A protein]-C-terminal L-leucine + H(+) + methanol => [phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O"}
{"X":43606,"RHEA_ID":41956,"DIRECTION":"UN","MASTER_ID":41956,"ec":"3.1.4.37","compounds":"2',3'-cyclic CMP + H2O = cytidine 2'-phosphate + H(+)"}
{"X":43607,"RHEA_ID":51922,"compounds":"A + a quinol => a quinone + AH2"}
{"X":43608,"RHEA_ID":41958,"compounds":"cytidine 2'-phosphate + H(+) => 2',3'-cyclic CMP + H2O"}
{"X":43609,"RHEA_ID":62293,"compounds":"(8aS)-3-{[2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl]methyl}-1H,2H,6H,7H,8H,8aH-pyrrolo[1,2-a]pyrazin-1-one + A + H(+) => 1-hydroxy-3-{[2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl]methyl}-6H,7H,8H-5lambda5-pyrrolo[1,2-a]pyrazine + AH2"}
{"X":43610,"RHEA_ID":41960,"compounds":"ganglioside GA2 (d18:1(4E)) + UDP-alpha-D-galactose = ganglioside GA1 (d18:1(4E)) + H(+) + UDP"}
{"X":43611,"RHEA_ID":51926,"compounds":"A + beta-dihydromenaquinone-9 => AH2 + menaquinone-9"}
{"X":43612,"RHEA_ID":41962,"compounds":"ganglioside GA1 (d18:1(4E)) + H(+) + UDP => ganglioside GA2 (d18:1(4E)) + UDP-alpha-D-galactose"}
{"X":43613,"RHEA_ID":62297,"compounds":"(+)-premalbrancheamide + 2 chloride + 2 FAD + 4 H(+) => (+)-malbrancheamide + 2 FADH2"}
{"X":43614,"RHEA_ID":41964,"compounds":"butanoyl-CoA + O2 = (2E)-butenoyl-CoA + H2O2"}
{"X":43615,"RHEA_ID":51930,"compounds":"(S)-2,3-diaminopropanoate + 2-oxoglutarate + H(+) + NADH => H2O + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + NAD(+)"}
{"X":43616,"RHEA_ID":41966,"compounds":"(2E)-butenoyl-CoA + H2O2 => butanoyl-CoA + O2"}
{"X":43617,"RHEA_ID":62301,"compounds":"1-hydroxy-3-{[2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl]methyl}-6H,7H,8H-5lambda5-pyrrolo[1,2-a]pyrazine + H(+) + NADPH => 1-hydroxy-3-{[2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine + NADP(+)"}
{"X":43618,"RHEA_ID":41968,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GM1b (d18:1(4E)) = CMP + ganglioside GD1aalpha (d18:1(4E)) + H(+)"}
{"X":43619,"RHEA_ID":51934,"DIRECTION":"RL","MASTER_ID":51932,"metacyc":"RXN-8339","compounds":"2 [Fe(II)-cytochrome c3] + thiosulfate => 2 [Fe(III)-cytochrome c3] + hydrogen sulfide + sulfite"}
{"X":43620,"RHEA_ID":41970,"compounds":"CMP + ganglioside GD1aalpha (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM1b (d18:1(4E))"}
{"X":43621,"RHEA_ID":51936,"DIRECTION":"UN","MASTER_ID":51936,"ec":"1.8.5.7","compounds":"2-(glutathione-S-yl)-hydroquinone + glutathione = glutathione disulfide + hydroquinone"}
{"X":43622,"RHEA_ID":41972,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GD1a (18:1(4E)) = CMP + ganglioside GT1aalpha (d18:1(4E)) + H(+)"}
{"X":43623,"RHEA_ID":41973,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GD1a (18:1(4E)) => CMP + ganglioside GT1aalpha (d18:1(4E)) + H(+)"}
{"X":43624,"RHEA_ID":41974,"compounds":"CMP + ganglioside GT1aalpha (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GD1a (18:1(4E))"}
{"X":43625,"RHEA_ID":51940,"compounds":"(1E,2S)-2-methylbutanal oxime = (1Z,2S)-2-methylbutanal oxime"}
{"X":43626,"RHEA_ID":41976,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GT1b (d18:1(4E)) = CMP + ganglioside GQ1b alpha (d18:1(4E)) + H(+)"}
{"X":43627,"RHEA_ID":41977,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GT1b (d18:1(4E)) => CMP + ganglioside GQ1b alpha (d18:1(4E)) + H(+)"}
{"X":43628,"RHEA_ID":41978,"compounds":"CMP + ganglioside GQ1b alpha (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GT1b (d18:1(4E))"}
{"X":43629,"RHEA_ID":41979,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GT1b (d18:1(4E)) <=> CMP + ganglioside GQ1b alpha (d18:1(4E)) + H(+)"}
{"X":43630,"RHEA_ID":51945,"DIRECTION":"LR","MASTER_ID":51944,"metacyc":"RXN-18564","compounds":"8-amino-8-demethylriboflavin + 2 S-adenosyl-L-methionine => 2 H(+) + roseoflavin + 2 S-adenosyl-L-homocysteine"}
{"X":43631,"RHEA_ID":62315,"compounds":"salicylate + UDP-alpha-D-glucose <=> H(+) + salicylate 2-O-beta-D-glucoside + UDP"}
{"X":43632,"RHEA_ID":41982,"compounds":"5alpha-pregnane-3,20-dione + H(+) + NADH => 3alpha-hydroxy-5alpha-pregnan-20-one + NAD(+)"}
{"X":43633,"RHEA_ID":41983,"compounds":"3alpha-hydroxy-5alpha-pregnan-20-one + NAD(+) <=> 5alpha-pregnane-3,20-dione + H(+) + NADH"}
{"X":43634,"RHEA_ID":51949,"DIRECTION":"LR","MASTER_ID":51948,"metacyc":"RXN-9642","compounds":"(2S)-2-methylbutanenitrile + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-2-methylbutanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43635,"RHEA_ID":51950,"compounds":"2-hydroxy-2-methylbutanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2S)-2-methylbutanenitrile + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":43636,"RHEA_ID":41986,"compounds":"acetone + H(+) + NADH => NAD(+) + propan-2-ol"}
{"X":43637,"RHEA_ID":51953,"DIRECTION":"LR","MASTER_ID":51952,"metacyc":"RXN-18099","compounds":"(E)-2-methylpropanal oxime + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-2-methylpropanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43638,"RHEA_ID":62323,"compounds":"(+)-premalbrancheamide + chloride + FAD + 2 H(+) <=> (+)-isomalbrancheamide B + FADH2"}
{"X":43639,"RHEA_ID":41990,"compounds":"5alpha-pregnane-3,20-dione + H(+) + NADH => 3beta-hydroxy-5alpha-pregnane-20-one + NAD(+)"}
{"X":43640,"RHEA_ID":41991,"compounds":"3beta-hydroxy-5alpha-pregnane-20-one + NAD(+) <=> 5alpha-pregnane-3,20-dione + H(+) + NADH"}
{"X":43641,"RHEA_ID":41992,"compounds":"17beta-hydroxy-5alpha-androstan-3-one + NAD(+) = 5alpha-androstan-3,17-dione + H(+) + NADH"}
{"X":43642,"RHEA_ID":45289,"compounds":"2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 2 O2 => 2-glyceryl-prostaglandin G2"}
{"X":43643,"RHEA_ID":41995,"compounds":"17beta-hydroxy-5alpha-androstan-3-one + NAD(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADH"}
{"X":43644,"RHEA_ID":41996,"compounds":"globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose = globoside GalGb4Cer (d18:1(4E)) + H(+) + UDP"}
{"X":43645,"RHEA_ID":62331,"compounds":"(+)-isomalbrancheamide B + chloride + FAD + 2 H(+) <=> (+)-malbrancheamide + FADH2"}
{"X":43646,"RHEA_ID":41999,"compounds":"globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose <=> globoside GalGb4Cer (d18:1(4E)) + H(+) + UDP"}
{"X":43647,"RHEA_ID":42000,"compounds":"a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = H(+) + isogloboside iGb3Cer (d18:1(4E)) + UDP"}
{"X":43648,"RHEA_ID":51966,"compounds":"2-hydroxy-2-methylpropanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 2-methylpropanenitrile + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":43649,"RHEA_ID":42002,"compounds":"H(+) + isogloboside iGb3Cer (d18:1(4E)) + UDP => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose"}
{"X":43650,"RHEA_ID":42003,"compounds":"a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose <=> H(+) + isogloboside iGb3Cer (d18:1(4E)) + UDP"}
{"X":43651,"RHEA_ID":42004,"DIRECTION":"UN","MASTER_ID":42004,"ec":"1.1.1.53","compounds":"5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH"}
{"X":43652,"RHEA_ID":62339,"compounds":"AMP + ATP <=> adenosine 3'-diphosphate,5'-phosphate + AMP + H(+)"}
{"X":43653,"RHEA_ID":42006,"compounds":"17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH => 5alpha-androstane-3alpha,17beta-diol + NAD(+)"}
{"X":43654,"RHEA_ID":51972,"DIRECTION":"UN","MASTER_ID":51972,"ec":"1.14.14.42","compounds":"an L-polyhomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":43655,"RHEA_ID":42008,"compounds":"5alpha-pregnan-20beta-ol-3-one + NAD(+) = 5alpha-pregnane-3,20-dione + H(+) + NADH"}
{"X":43656,"RHEA_ID":62343,"compounds":"(+)-premalbrancheamide + bromide + FAD + 2 H(+) <=> (+)-malbrancheamide C + FADH2"}
{"X":43657,"RHEA_ID":42010,"compounds":"5alpha-pregnane-3,20-dione + H(+) + NADH => 5alpha-pregnan-20beta-ol-3-one + NAD(+)"}
{"X":43658,"RHEA_ID":42011,"compounds":"5alpha-pregnan-20beta-ol-3-one + NAD(+) <=> 5alpha-pregnane-3,20-dione + H(+) + NADH"}
{"X":43659,"RHEA_ID":42012,"compounds":"cortisol + NAD(+) = 11beta,17alpha-dihydroxypregn-4-ene-3,20,21-trione + H(+) + NADH"}
{"X":43660,"RHEA_ID":51978,"compounds":"an L-N,N-dihydroxypolyhomomethionine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an L-N-hydroxypolyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":43661,"RHEA_ID":42015,"compounds":"cortisol + NAD(+) <=> 11beta,17alpha-dihydroxypregn-4-ene-3,20,21-trione + H(+) + NADH"}
{"X":43662,"RHEA_ID":42016,"compounds":"cortisone + NAD(+) = 17alpha-hydroxypregn-4-en-3,11,20-trione-21-al + H(+) + NADH"}
{"X":43663,"RHEA_ID":62351,"compounds":"H(+) + NADPH + notoamide E + O2 <=> H2O + NADP(+) + notoamide C"}
{"X":43664,"RHEA_ID":42019,"compounds":"cortisone + NAD(+) <=> 17alpha-hydroxypregn-4-en-3,11,20-trione-21-al + H(+) + NADH"}
{"X":43665,"RHEA_ID":42020,"compounds":"11-dehydrocorticosterone + NAD(+) = H(+) + NADH + pregn-4-ene-3,11,20,21-tetraone"}
{"X":43666,"RHEA_ID":62355,"compounds":"H(+) + NADPH + notoamide E + O2 <=> H2O + NADP(+) + notoamide D"}
{"X":43667,"RHEA_ID":51987,"compounds":"all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43668,"RHEA_ID":42023,"compounds":"11-dehydrocorticosterone + NAD(+) <=> H(+) + NADH + pregn-4-ene-3,11,20,21-tetraone"}
{"X":43669,"RHEA_ID":42024,"compounds":"3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD(+) = 3beta-hydroxy-7-oxo-5beta-cholan-24-oate + H(+) + NADH"}
{"X":43670,"RHEA_ID":51990,"compounds":"18S-resolvin E1 => (5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O"}
{"X":43671,"RHEA_ID":51991,"compounds":"(5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O <=> 18S-resolvin E1"}
{"X":43672,"RHEA_ID":42027,"compounds":"3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD(+) <=> 3beta-hydroxy-7-oxo-5beta-cholan-24-oate + H(+) + NADH"}
{"X":43673,"RHEA_ID":42028,"compounds":"NAD(+) + ursodeoxycholate = 7-oxolithocholate + H(+) + NADH"}
{"X":43674,"RHEA_ID":51994,"compounds":"an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => an (E)-omega-(methylsulfanyl)-alkanal oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":43675,"RHEA_ID":62364,"compounds":"FMNH2 + O2 + thymine = (Z)-2-methylureidoacrylate + FMN-N(5)-oxide + 2 H(+)"}
{"X":43676,"RHEA_ID":42031,"compounds":"NAD(+) + ursodeoxycholate <=> 7-oxolithocholate + H(+) + NADH"}
{"X":43677,"RHEA_ID":42032,"DIRECTION":"UN","MASTER_ID":42032,"ec":"1.14.11.27","compounds":"2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + L-lysyl(36)-[histone H3] + 2 succinate"}
{"X":43678,"RHEA_ID":42033,"DIRECTION":"LR","MASTER_ID":42032,"metacyc":"RXN-13186","compounds":"2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 O2 => 2 CO2 + 2 formaldehyde + L-lysyl(36)-[histone H3] + 2 succinate"}
{"X":43679,"RHEA_ID":62368,"compounds":"Fe(2+)(out) + 2 hydrogencarbonate(out) = Fe(2+)(in) + 2 hydrogencarbonate(in)"}
{"X":43680,"RHEA_ID":52000,"compounds":"a 1-(methylsulfanyl)-4-aci-nitroalkane + glutathione = an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O"}
{"X":43681,"RHEA_ID":42036,"compounds":"chenodeoxycholate + NAD(+) = 7-oxolithocholate + H(+) + NADH"}
{"X":43682,"RHEA_ID":52002,"compounds":"an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O => a 1-(methylsulfanyl)-4-aci-nitroalkane + glutathione"}
{"X":43683,"RHEA_ID":42038,"compounds":"7-oxolithocholate + H(+) + NADH => chenodeoxycholate + NAD(+)"}
{"X":43684,"RHEA_ID":42039,"compounds":"chenodeoxycholate + NAD(+) <=> 7-oxolithocholate + H(+) + NADH"}
{"X":43685,"RHEA_ID":42040,"compounds":"ganglioside GM1 (d18:1(4E)) + GDP-beta-L-fucose = fucosyl ganglioside GM1 (d18:1(4E)) + GDP + H(+)"}
{"X":43686,"RHEA_ID":42041,"compounds":"ganglioside GM1 (d18:1(4E)) + GDP-beta-L-fucose => fucosyl ganglioside GM1 (d18:1(4E)) + GDP + H(+)"}
{"X":43687,"RHEA_ID":62404,"compounds":"(R)-2-hydroxyhexadecanoate + O2 = CO2 + H2O + pentadecanoate"}
{"X":43688,"RHEA_ID":42043,"compounds":"ganglioside GM1 (d18:1(4E)) + GDP-beta-L-fucose <=> fucosyl ganglioside GM1 (d18:1(4E)) + GDP + H(+)"}
{"X":43689,"RHEA_ID":42044,"compounds":"GDP-beta-L-fucose + globoside GalGb4Cer (d18:1(4E)) = GDP + globoside Globo-H (d18:1(4E)) + H(+)"}
{"X":43690,"RHEA_ID":52014,"compounds":"11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate => 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + ATP + CoA"}
{"X":43691,"RHEA_ID":42046,"compounds":"GDP + globoside Globo-H (d18:1(4E)) + H(+) => GDP-beta-L-fucose + globoside GalGb4Cer (d18:1(4E))"}
{"X":43692,"RHEA_ID":42047,"compounds":"GDP-beta-L-fucose + globoside GalGb4Cer (d18:1(4E)) <=> GDP + globoside Globo-H (d18:1(4E)) + H(+)"}
{"X":43693,"RHEA_ID":42048,"compounds":"3-hydroxybutanoyl-CoA + NAD(+) = acetoacetyl-CoA + H(+) + NADH"}
{"X":43694,"RHEA_ID":52018,"compounds":"14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoyl-CoA + AMP + diphosphate => 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + ATP + CoA"}
{"X":43695,"RHEA_ID":62432,"DIRECTION":"UN","MASTER_ID":62432,"ec":"2.5.1.25","compounds":"a uridine in tRNA + S-adenosyl-L-methionine = a 3-[(3S)-3-amino-3-carboxypropyl]-uridine in tRNA + H(+) + S-methyl-5'-thioadenosine"}
{"X":43696,"RHEA_ID":42051,"compounds":"3-hydroxybutanoyl-CoA + NAD(+) <=> acetoacetyl-CoA + H(+) + NADH"}
{"X":43697,"RHEA_ID":42052,"compounds":"9-cis-retinol + NAD(+) = 9-cis-retinal + H(+) + NADH"}
{"X":43698,"RHEA_ID":52022,"compounds":"A + H2O + resolvin E2 => (5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2"}
{"X":43699,"RHEA_ID":52023,"compounds":"(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2 <=> A + H2O + resolvin E2"}
{"X":43700,"RHEA_ID":52024,"compounds":"(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2 = 18S-resolvin E2 + A + H2O"}
{"X":43701,"RHEA_ID":42056,"compounds":"13-cis-retinol + NAD(+) = 13-cis-retinal + H(+) + NADH"}
{"X":43702,"RHEA_ID":52026,"compounds":"18S-resolvin E2 + A + H2O => (5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2"}
{"X":43703,"RHEA_ID":62464,"compounds":"1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O = 2-nonadioyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":43704,"RHEA_ID":42059,"compounds":"13-cis-retinol + NAD(+) <=> 13-cis-retinal + H(+) + NADH"}
{"X":43705,"RHEA_ID":42060,"DIRECTION":"UN","MASTER_ID":42060,"ec":"1.1.1.315","compounds":"11-cis-retinol + NAD(+) = 11-cis-retinal + H(+) + NADH"}
{"X":43706,"RHEA_ID":52030,"compounds":"a jasmonate + an L-alpha-amino acid => a jasmonyl-L-amino acid + H2O"}
{"X":43707,"RHEA_ID":62473,"compounds":"1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-nonadioyl-sn-glycero-3-phosphocholine"}
{"X":43708,"RHEA_ID":42064,"DIRECTION":"UN","MASTER_ID":42064,"ec":"2.7.7.86","compounds":"ATP + GTP = 2',3'-cGAMP + 2 diphosphate"}
{"X":43709,"RHEA_ID":42065,"compounds":"ATP + GTP => 2',3'-cGAMP + 2 diphosphate"}
{"X":43710,"RHEA_ID":52035,"compounds":"H2O + L-isoleucine-(+)-7-isojasmonate <=> (+)-7-isojasmonate + L-isoleucine"}
{"X":43711,"RHEA_ID":62481,"compounds":"1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O => 2-glutaroyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":43712,"RHEA_ID":42068,"compounds":"(3R,5R)-clavulanate-9-aldehyde + H(+) + NADPH = clavulanate + NADP(+)"}
{"X":43713,"RHEA_ID":52038,"compounds":"L-isoleucine + tuberonate => H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate"}
{"X":43714,"RHEA_ID":52039,"compounds":"H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate <=> L-isoleucine + tuberonate"}
{"X":43715,"RHEA_ID":52040,"compounds":"L-cystine = 2-aminoprop-2-enoate + S-sulfanyl-L-cysteine"}
{"X":43716,"RHEA_ID":42072,"DIRECTION":"UN","MASTER_ID":42072,"ec":"4.2.1.163","compounds":"(4Z)-2-oxohept-4-enedioate + H2O = (4S)-4-hydroxy-2-oxoheptanedioate"}
{"X":43717,"RHEA_ID":52042,"compounds":"2-aminoprop-2-enoate + S-sulfanyl-L-cysteine => L-cystine"}
{"X":43718,"RHEA_ID":52043,"compounds":"L-cystine <=> 2-aminoprop-2-enoate + S-sulfanyl-L-cysteine"}
{"X":43719,"RHEA_ID":52044,"DIRECTION":"UN","MASTER_ID":52044,"ec":"2.4.1.350","compounds":"mogrol + UDP-alpha-D-glucose = H(+) + mogroside IE + UDP"}
{"X":43720,"RHEA_ID":42076,"compounds":"2-hydroxyglutarate + acetyl-CoA = 2-hydroxyglutaryl-CoA + acetate"}
{"X":43721,"RHEA_ID":62491,"compounds":"1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":43722,"RHEA_ID":62508,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine"}
{"X":43723,"RHEA_ID":52048,"compounds":"9-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)-octadecenoate + 9-hydroxy-octadecanoate + H(+)"}
{"X":43724,"RHEA_ID":42080,"DIRECTION":"UN","MASTER_ID":42080,"ec":"1.2.1.36","compounds":"all-trans-retinal + H2O + NAD(+) = all-trans-retinoate + 2 H(+) + NADH"}
{"X":43725,"RHEA_ID":62511,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine"}
{"X":43726,"RHEA_ID":52051,"compounds":"9-(9Z-octadecenoyloxy)-octadecanoate + H2O <=> (9Z)-octadecenoate + 9-hydroxy-octadecanoate + H(+)"}
{"X":43727,"RHEA_ID":52052,"compounds":"9-hexadecanoyloxy-octadecanoate + H2O = 9-hydroxy-octadecanoate + H(+) + hexadecanoate"}
{"X":43728,"RHEA_ID":42084,"compounds":"9-cis-retinal + H2O + NAD(+) = 9-cis-retinoate + 2 H(+) + NADH"}
{"X":43729,"RHEA_ID":52054,"compounds":"9-hydroxy-octadecanoate + H(+) + hexadecanoate => 9-hexadecanoyloxy-octadecanoate + H2O"}
{"X":43730,"RHEA_ID":52055,"compounds":"9-hexadecanoyloxy-octadecanoate + H2O <=> 9-hydroxy-octadecanoate + H(+) + hexadecanoate"}
{"X":43731,"RHEA_ID":42087,"compounds":"9-cis-retinal + H2O + NAD(+) <=> 9-cis-retinoate + 2 H(+) + NADH"}
{"X":43732,"RHEA_ID":42088,"compounds":"all-trans-retinal + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43733,"RHEA_ID":62519,"compounds":"beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-galactosamine <=> H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP"}
{"X":43734,"RHEA_ID":42090,"compounds":"all-trans-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-retinal + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":43735,"RHEA_ID":42091,"compounds":"all-trans-retinal + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43736,"RHEA_ID":42092,"compounds":"all-trans-retinol + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-retinal + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43737,"RHEA_ID":52062,"compounds":"(9Z)-octadecenoate + 12-hydroxyoctadecanoate + H(+) => 12-(9Z-octadecenoyloxy)-octadecanoate + H2O"}
{"X":43738,"RHEA_ID":42094,"compounds":"all-trans-retinal + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-retinol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":43739,"RHEA_ID":42095,"compounds":"all-trans-retinol + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-retinal + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43740,"RHEA_ID":42096,"DIRECTION":"UN","MASTER_ID":42096,"ec":"6.1.2.2","compounds":"ATP + carbamoyl phosphate + H2O + tobramycin = AMP + diphosphate + H(+) + nebramycin 5' + phosphate"}
{"X":43741,"RHEA_ID":52066,"compounds":"(9Z)-octadecenoate + 13-hydroxy-octadecanoate + H(+) => 13-(9Z-octadecenoyloxy)-octadecanoate + H2O"}
{"X":43742,"RHEA_ID":52067,"compounds":"13-(9Z-octadecenoyloxy)-octadecanoate + H2O <=> (9Z)-octadecenoate + 13-hydroxy-octadecanoate + H(+)"}
{"X":43743,"RHEA_ID":52068,"compounds":"9-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H(+)"}
{"X":43744,"RHEA_ID":42100,"DIRECTION":"UN","MASTER_ID":42100,"ec":"6.1.2.2","compounds":"ATP + carbamoyl phosphate + H2O + kanamycin A = 6''-O-carbamoylkanamycin A + AMP + diphosphate + H(+) + phosphate"}
{"X":43745,"RHEA_ID":62531,"compounds":"2 [Fe(II)cytochrome c] + digoxin + 3 H(+) <=> 2 [Fe(III)cytochrome c] + dihydrodigoxin"}
{"X":43746,"RHEA_ID":52071,"compounds":"9-(9Z-hexadecenoyloxy)-octadecanoate + H2O <=> (9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H(+)"}
{"X":43747,"RHEA_ID":52072,"compounds":"12-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 12-hydroxyoctadecanoate + H(+)"}
{"X":43748,"RHEA_ID":42104,"compounds":"2-hydroxyethylphosphonate + methylcob(III)alamin + S-adenosyl-L-methionine = (S)-2-hydroxypropylphosphonate + 5'-deoxyadenosine + cob(III)alamin + L-methionine"}
{"X":43749,"RHEA_ID":62535,"compounds":"2 [Fe(II)cytochrome c] + digitoxin + 3 H(+) <=> 2 [Fe(III)cytochrome c] + dihydrodigitoxin"}
{"X":43750,"RHEA_ID":42106,"compounds":"(S)-2-hydroxypropylphosphonate + 5'-deoxyadenosine + cob(III)alamin + L-methionine => 2-hydroxyethylphosphonate + methylcob(III)alamin + S-adenosyl-L-methionine"}
{"X":43751,"RHEA_ID":42107,"compounds":"2-hydroxyethylphosphonate + methylcob(III)alamin + S-adenosyl-L-methionine <=> (S)-2-hydroxypropylphosphonate + 5'-deoxyadenosine + cob(III)alamin + L-methionine"}
{"X":43752,"RHEA_ID":42108,"compounds":"(20S)-hydroxypregn-4-en-3-one + NAD(+) = H(+) + NADH + progesterone"}
{"X":43753,"RHEA_ID":52078,"compounds":"(9Z)-hexadecenoate + 13-hydroxy-octadecanoate + H(+) => 13-(9Z-hexadecenoyloxy)-octadecanoate + H2O"}
{"X":43754,"RHEA_ID":42110,"compounds":"H(+) + NADH + progesterone => (20S)-hydroxypregn-4-en-3-one + NAD(+)"}
{"X":43755,"RHEA_ID":42111,"compounds":"(20S)-hydroxypregn-4-en-3-one + NAD(+) <=> H(+) + NADH + progesterone"}
{"X":43756,"RHEA_ID":42112,"compounds":"(20S)-hydroxypregn-4-en-3-one + NADP(+) = H(+) + NADPH + progesterone"}
{"X":43757,"RHEA_ID":62543,"compounds":"2 [Fe(II)cytochrome c] + 3 H(+) + ouabain <=> 2 [Fe(III)cytochrome c] + dihydroouabain"}
{"X":43758,"RHEA_ID":42114,"compounds":"H(+) + NADPH + progesterone => (20S)-hydroxypregn-4-en-3-one + NADP(+)"}
{"X":43759,"RHEA_ID":42115,"compounds":"(20S)-hydroxypregn-4-en-3-one + NADP(+) <=> H(+) + NADPH + progesterone"}
{"X":43760,"RHEA_ID":42116,"compounds":"5alpha-androstane-3alpha,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH"}
{"X":43761,"RHEA_ID":62547,"compounds":"2 [Fe(II)cytochrome c] + 3 H(+) + ouabagenin <=> 2 [Fe(III)cytochrome c] + dihydroouabagenin"}
{"X":43762,"RHEA_ID":42118,"compounds":"17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH => 5alpha-androstane-3alpha,17beta-diol + NADP(+)"}
{"X":43763,"RHEA_ID":42119,"compounds":"5alpha-androstane-3alpha,17beta-diol + NADP(+) <=> 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH"}
{"X":43764,"RHEA_ID":42120,"compounds":"17beta-hydroxy-5alpha-androstan-3-one + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH"}
{"X":43765,"RHEA_ID":52090,"compounds":"5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate => 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + ATP + CoA"}
{"X":43766,"RHEA_ID":52091,"compounds":"5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + ATP + CoA <=> 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate"}
{"X":43767,"RHEA_ID":42123,"compounds":"17beta-hydroxy-5alpha-androstan-3-one + NADP(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADPH"}
{"X":43768,"RHEA_ID":42124,"compounds":"5alpha-androstane-3alpha,17beta-diol + NAD(+) = 3alpha-hydroxy-5alpha-androstan-17-one + H(+) + NADH"}
{"X":43769,"RHEA_ID":42125,"compounds":"5alpha-androstane-3alpha,17beta-diol + NAD(+) => 3alpha-hydroxy-5alpha-androstan-17-one + H(+) + NADH"}
{"X":43770,"RHEA_ID":52095,"compounds":"5-(9Z-hexadecenoyloxy)-octadecanoate + H2O <=> (9Z)-hexadecenoate + 5-hydroxy-octadecanoate + H(+)"}
{"X":43771,"RHEA_ID":42127,"compounds":"5alpha-androstane-3alpha,17beta-diol + NAD(+) <=> 3alpha-hydroxy-5alpha-androstan-17-one + H(+) + NADH"}
{"X":43772,"RHEA_ID":42128,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoylsphinganine = a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphoethanolamine"}
{"X":43773,"RHEA_ID":52098,"compounds":"9-hydroxy-octadecanoate + H(+) + octadecanoate => 9-octadecanoyloxy-octadecanoate + H2O"}
{"X":43774,"RHEA_ID":52099,"compounds":"9-octadecanoyloxy-octadecanoate + H2O <=> 9-hydroxy-octadecanoate + H(+) + octadecanoate"}
{"X":43775,"RHEA_ID":42131,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoylsphinganine <=> a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphoethanolamine"}
{"X":43776,"RHEA_ID":42132,"DIRECTION":"UN","MASTER_ID":42132,"ec":"5.1.1.14","compounds":"isonocardicin C = nocardicin C"}
{"X":43777,"RHEA_ID":52102,"compounds":"(9Z)-octadecenoate + 5-hydroxy-octadecanoate + H(+) => 5-(9Z-octadecenoyloxy)-octadecanoate + H2O"}
{"X":43778,"RHEA_ID":52103,"compounds":"5-(9Z-octadecenoyloxy)-octadecanoate + H2O <=> (9Z)-octadecenoate + 5-hydroxy-octadecanoate + H(+)"}
{"X":43779,"RHEA_ID":52104,"DIRECTION":"UN","MASTER_ID":52104,"ec":"2.4.99.1","compounds":"a beta-D-galactoside + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H(+)"}
{"X":43780,"RHEA_ID":52105,"DIRECTION":"LR","MASTER_ID":52104,"metacyc":"RXN-18268","compounds":"a beta-D-galactoside + CMP-N-acetyl-beta-neuraminate => an N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H(+)"}
{"X":43781,"RHEA_ID":52106,"compounds":"an N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H(+) => a beta-D-galactoside + CMP-N-acetyl-beta-neuraminate"}
{"X":43782,"RHEA_ID":45434,"compounds":"H(+) + N-(9Z-octadecenoyl) ethanolamine + sn-glycerol 3-phosphate => H2O + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":43783,"RHEA_ID":42139,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphinganine <=> a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphoethanolamine"}
{"X":43784,"RHEA_ID":52109,"compounds":"5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA => 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate"}
{"X":43785,"RHEA_ID":52110,"compounds":"5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate => 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA"}
{"X":43786,"RHEA_ID":42142,"compounds":"a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-4-hydroxysphinganine-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-4-hydroxysphinganine"}
{"X":43787,"RHEA_ID":42143,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-4-hydroxysphinganine <=> a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-4-hydroxysphinganine-phosphocholine"}
{"X":43788,"RHEA_ID":42144,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoyl-4-hydroxysphinganine = a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-4-hydroxysphinganine-1-phosphoethanolamine"}
{"X":43789,"RHEA_ID":52114,"compounds":"12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate => 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA"}
{"X":43790,"RHEA_ID":42146,"compounds":"a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-4-hydroxysphinganine-1-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoyl-4-hydroxysphinganine"}
{"X":43791,"RHEA_ID":42147,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoyl-4-hydroxysphinganine <=> a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-4-hydroxysphinganine-1-phosphoethanolamine"}
{"X":43792,"RHEA_ID":42148,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acyl-(4R)-4-hydroxysphinganine = a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoethanolamine"}
{"X":43793,"RHEA_ID":52118,"compounds":"15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate => 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA"}
{"X":43794,"RHEA_ID":52119,"compounds":"15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA <=> 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate"}
{"X":43795,"RHEA_ID":42151,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acyl-(4R)-4-hydroxysphinganine <=> a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoethanolamine"}
{"X":43796,"RHEA_ID":42152,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acyl-(4R)-4-hydroxysphinganine = a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-phosphocholine"}
{"X":43797,"RHEA_ID":52122,"compounds":"(19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":43798,"RHEA_ID":52123,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43799,"RHEA_ID":42155,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acyl-(4R)-4-hydroxysphinganine <=> a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-phosphocholine"}
{"X":43800,"RHEA_ID":52125,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => (19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43801,"RHEA_ID":42157,"compounds":"3alpha-hydroxy-5alpha-androstan-17-one + H(+) + NADPH => 5alpha-androstane-3alpha,17beta-diol + NADP(+)"}
{"X":43802,"RHEA_ID":52127,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43803,"RHEA_ID":42159,"compounds":"3alpha-hydroxy-5alpha-androstan-17-one + H(+) + NADPH <=> 5alpha-androstane-3alpha,17beta-diol + NADP(+)"}
{"X":43804,"RHEA_ID":42160,"DIRECTION":"UN","MASTER_ID":42160,"ec":"1.14.19.37","compounds":"(11Z,14Z)-eicosadienoyl-CoA + AH2 + O2 = (5Z,11Z,14Z)-eicosatrienoyl-CoA + A + 2 H2O"}
{"X":43805,"RHEA_ID":42161,"compounds":"(11Z,14Z)-eicosadienoyl-CoA + AH2 + O2 => (5Z,11Z,14Z)-eicosatrienoyl-CoA + A + 2 H2O"}
{"X":43806,"RHEA_ID":52131,"compounds":"adenosine-5'-diphospho-5'-(DNA) + H2O <=> AMP + 2 H(+) + phospho-5'-(DNA)"}
{"X":43807,"RHEA_ID":52133,"DIRECTION":"LR","MASTER_ID":52132,"metacyc":"RXN-17914","compounds":"adenosine-5'-diphospho-5'-(ribonucleotide)-(DNA) + H2O => 5'-phospho-(ribonucleotide)-(DNA) + AMP + 2 H(+)"}
{"X":43808,"RHEA_ID":42165,"compounds":"(11Z,14Z,17Z)-eicosatrienoyl-CoA + AH2 + O2 => (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + A + 2 H2O"}
{"X":43809,"RHEA_ID":52135,"compounds":"adenosine-5'-diphospho-5'-(ribonucleotide)-(DNA) + H2O <=> 5'-phospho-(ribonucleotide)-(DNA) + AMP + 2 H(+)"}
{"X":43810,"RHEA_ID":52136,"DIRECTION":"UN","MASTER_ID":52136,"ec":"3.6.1.70","compounds":"guanosine-5'-diphospho-5'-(DNA) + H2O = GMP + 2 H(+) + phospho-5'-(DNA)"}
{"X":43811,"RHEA_ID":52137,"DIRECTION":"LR","MASTER_ID":52136,"metacyc":"RXN-17915","compounds":"guanosine-5'-diphospho-5'-(DNA) + H2O => GMP + 2 H(+) + phospho-5'-(DNA)"}
{"X":43812,"RHEA_ID":42169,"compounds":"20alpha-hydroxy-5beta-pregnan-3-one + NADP(+) => 5beta-pregnan-3,20-dione + H(+) + NADPH"}
{"X":43813,"RHEA_ID":52139,"compounds":"guanosine-5'-diphospho-5'-(DNA) + H2O <=> GMP + 2 H(+) + phospho-5'-(DNA)"}
{"X":43814,"RHEA_ID":42171,"compounds":"20alpha-hydroxy-5beta-pregnan-3-one + NADP(+) <=> 5beta-pregnan-3,20-dione + H(+) + NADPH"}
{"X":43815,"RHEA_ID":52141,"DIRECTION":"LR","MASTER_ID":52140,"metacyc":"RXN-17912","compounds":"(DNA)-3'-diphospho-5'-guanosine + H2O => (DNA)-3'-phosphate + GMP + 2 H(+)"}
{"X":43816,"RHEA_ID":42173,"compounds":"(11Z)-eicosenoyl-CoA + AH2 + O2 => (8Z,11Z)-eicosadienoyl-CoA + A + 2 H2O"}
{"X":43817,"RHEA_ID":42174,"compounds":"(8Z,11Z)-eicosadienoyl-CoA + A + 2 H2O => (11Z)-eicosenoyl-CoA + AH2 + O2"}
{"X":43818,"RHEA_ID":52144,"DIRECTION":"UN","MASTER_ID":52144,"ec":"2.3.3.19","compounds":"3-phosphonopyruvate + acetyl-CoA + H2O = (R)-2-(phosphonomethyl)malate + CoA + H(+)"}
{"X":43819,"RHEA_ID":52145,"DIRECTION":"LR","MASTER_ID":52144,"metacyc":"RXN-15074","compounds":"3-phosphonopyruvate + acetyl-CoA + H2O => (R)-2-(phosphonomethyl)malate + CoA + H(+)"}
{"X":43820,"RHEA_ID":42177,"compounds":"(9Z)-tetradecenoyl-CoA + AH2 + O2 => (9Z,12Z)-tetradecadienoyl-CoA + A + 2 H2O"}
{"X":43821,"RHEA_ID":62616,"compounds":"a lactoside III(4)-a-Fuc-Lc4Cer + GDP-beta-L-fucose = a lactoside IV(2),III(4)-a-[Fuc]2-Lc4Cer + GDP + H(+)"}
{"X":43822,"RHEA_ID":52148,"DIRECTION":"UN","MASTER_ID":52148,"ec":"2.4.1.195","compounds":"an (E)-omega-(methylsulfanyl)alkyl-thiohydroximate + UDP-alpha-D-glucose = an aliphatic desulfo-glucosinolate + UDP"}
{"X":43823,"RHEA_ID":42180,"compounds":"(6Z,9Z,12Z)-octadecatrienoyl-CoA + AH2 + O2 = (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + A + 2 H2O"}
{"X":43824,"RHEA_ID":42181,"compounds":"(6Z,9Z,12Z)-octadecatrienoyl-CoA + AH2 + O2 => (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + A + 2 H2O"}
{"X":43825,"RHEA_ID":52151,"compounds":"an (E)-omega-(methylsulfanyl)alkyl-thiohydroximate + UDP-alpha-D-glucose <=> an aliphatic desulfo-glucosinolate + UDP"}
{"X":43826,"RHEA_ID":52152,"DIRECTION":"UN","MASTER_ID":52152,"ec":"2.4.1.195","compounds":"(E)-2-(1H-indol-3-yl)-1-thioacetohydroximate + UDP-alpha-D-glucose = indolylmethyl-desulfoglucosinolate + UDP"}
{"X":43827,"RHEA_ID":52153,"DIRECTION":"LR","MASTER_ID":52152,"metacyc":"RXN-1442","compounds":"(E)-2-(1H-indol-3-yl)-1-thioacetohydroximate + UDP-alpha-D-glucose => indolylmethyl-desulfoglucosinolate + UDP"}
{"X":43828,"RHEA_ID":42185,"compounds":"5alpha-androstane-3beta,17beta-diol + NAD(+) => 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH"}
{"X":43829,"RHEA_ID":62648,"compounds":"(12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(12S)-hydroxy-(6E,8Z,10E,14Z)-eicosatetraenoate"}
{"X":43830,"RHEA_ID":52156,"DIRECTION":"UN","MASTER_ID":52156,"ec":"1.14.14.44","compounds":"(E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] = (R)-mandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43831,"RHEA_ID":52157,"DIRECTION":"LR","MASTER_ID":52156,"metacyc":"RXN-18096","compounds":"(E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] => (R)-mandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43832,"RHEA_ID":42189,"compounds":"3beta-hydroxy-5alpha-androstan-17-one + NAD(+) => 5alpha-androstan-3,17-dione + H(+) + NADH"}
{"X":43833,"RHEA_ID":62652,"compounds":"acetyl-CoA + 6 H(+) + 6 malonyl-CoA = 6 CO2 + 7 CoA + H2O + YWA1"}
{"X":43834,"RHEA_ID":52160,"compounds":"(E)-phenylacetaldehyde oxime = (Z)-phenylacetaldehyde oxime"}
{"X":43835,"RHEA_ID":52161,"DIRECTION":"LR","MASTER_ID":52160,"metacyc":"RXN-12065","compounds":"(E)-phenylacetaldehyde oxime => (Z)-phenylacetaldehyde oxime"}
{"X":43836,"RHEA_ID":42193,"compounds":"(9Z)-pentadecenoyl-CoA + AH2 + O2 => (9Z,12Z)-pentadecadienoyl-CoA + A + 2 H2O"}
{"X":43837,"RHEA_ID":42194,"compounds":"(9Z,12Z)-pentadecadienoyl-CoA + A + 2 H2O => (9Z)-pentadecenoyl-CoA + AH2 + O2"}
{"X":43838,"RHEA_ID":52164,"DIRECTION":"UN","MASTER_ID":52164,"ec":"1.14.14.77","compounds":"O2 + phenylacetonitrile + reduced [NADPH--hemoprotein reductase] = (R)-mandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43839,"RHEA_ID":52165,"DIRECTION":"LR","MASTER_ID":52164,"metacyc":"RXN-18098","compounds":"O2 + phenylacetonitrile + reduced [NADPH--hemoprotein reductase] => (R)-mandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43840,"RHEA_ID":42197,"compounds":"(9Z)-heptadecenoyl-CoA + AH2 + O2 => (9Z,12Z)-heptadecadienoyl-CoA + A + 2 H2O"}
{"X":43841,"RHEA_ID":62660,"compounds":"2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol = (2'R)-atrovenetin"}
{"X":43842,"RHEA_ID":52168,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 8,9-epoxy-(5Z,11Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43843,"RHEA_ID":52169,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 8,9-epoxy-(5Z,11Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43844,"RHEA_ID":42201,"compounds":"corticosterone + NADP(+) => 11-dehydrocorticosterone + H(+) + NADPH"}
{"X":43845,"RHEA_ID":52171,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8,9-epoxy-(5Z,11Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43846,"RHEA_ID":52172,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 11,12-epoxy-(5Z,8Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43847,"RHEA_ID":52173,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 11,12-epoxy-(5Z,8Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43848,"RHEA_ID":42205,"compounds":"corticosterone + NAD(+) => 11-dehydrocorticosterone + H(+) + NADH"}
{"X":43849,"RHEA_ID":52175,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 11,12-epoxy-(5Z,8Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43850,"RHEA_ID":52176,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 14,15-epoxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43851,"RHEA_ID":52177,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 14,15-epoxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43852,"RHEA_ID":42209,"DIRECTION":"LR","MASTER_ID":42208,"metacyc":"RXN-18213","compounds":"an omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + H(+) + NADPH + O2 => an omega-(methylsulfinyl)-alkyl-glucosinolate + H2O + NADP(+)"}
{"X":43853,"RHEA_ID":42210,"compounds":"an omega-(methylsulfinyl)-alkyl-glucosinolate + H2O + NADP(+) => an omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + H(+) + NADPH + O2"}
{"X":43854,"RHEA_ID":52180,"DIRECTION":"UN","MASTER_ID":52180,"ec":"1.14.14.45","compounds":"(E)-(indol-3-yl)acetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] = (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43855,"RHEA_ID":52181,"DIRECTION":"LR","MASTER_ID":52180,"metacyc":"RXN-18158","compounds":"(E)-(indol-3-yl)acetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] => (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43856,"RHEA_ID":42213,"DIRECTION":"LR","MASTER_ID":42212,"metacyc":"RXN-20542","compounds":"1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O => a 2-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)"}
{"X":43857,"RHEA_ID":62676,"compounds":"10-formyldihydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-thiocarboxamide = 6-thio-IMP + 7,8-dihydrofolate + H2O"}
{"X":43858,"RHEA_ID":52184,"compounds":"(E)-(indol-3-yl)acetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] = 1-aci-nitro-2-(1H-indol-3-yl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43859,"RHEA_ID":52185,"DIRECTION":"LR","MASTER_ID":52184,"metacyc":"RXN-11413","compounds":"(E)-(indol-3-yl)acetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] => 1-aci-nitro-2-(1H-indol-3-yl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43860,"RHEA_ID":42217,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) => 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-1D-myo-inositol + CoA"}
{"X":43861,"RHEA_ID":62680,"compounds":"YWA1 = H(+) + H2O + norrubrofusarin"}
{"X":43862,"RHEA_ID":42219,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-1D-myo-inositol + CoA"}
{"X":43863,"RHEA_ID":52189,"DIRECTION":"LR","MASTER_ID":52188,"metacyc":"RXN-11421","compounds":"1-aci-nitro-2-(1H-indol-3-yl)ethane + glutathione => (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O"}
{"X":43864,"RHEA_ID":42221,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate => 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA"}
{"X":43865,"RHEA_ID":62684,"compounds":"norrubrofusarin + S-adenosyl-L-methionine = H(+) + rubrofusarin + S-adenosyl-L-homocysteine"}
{"X":43866,"RHEA_ID":52192,"DIRECTION":"UN","MASTER_ID":52192,"ec":"1.14.14.45","compounds":"(E)-phenylacetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] = (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43867,"RHEA_ID":42224,"compounds":"A + testosterone = AH2 + androst-4-ene-3,17-dione"}
{"X":43868,"RHEA_ID":52194,"compounds":"(Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (E)-phenylacetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":43869,"RHEA_ID":62688,"compounds":"4 norrubrofusarin + O2 = 2 H2O + 2 ustilaginoidin A"}
{"X":43870,"RHEA_ID":52196,"compounds":"(E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] = 1-aci-nitro-2-(phenyl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43871,"RHEA_ID":42228,"compounds":"17beta-estradiol + A = AH2 + estrone"}
{"X":43872,"RHEA_ID":42229,"compounds":"17beta-estradiol + A => AH2 + estrone"}
{"X":43873,"RHEA_ID":62704,"compounds":"glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine"}
{"X":43874,"RHEA_ID":52200,"compounds":"1-aci-nitro-2-(phenyl)ethane + glutathione = (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O"}
{"X":43875,"RHEA_ID":42232,"compounds":"(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(9Z)-octadecenoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":43876,"RHEA_ID":52202,"compounds":"(Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O => 1-aci-nitro-2-(phenyl)ethane + glutathione"}
{"X":43877,"RHEA_ID":62708,"compounds":"(indol-3-yl)butanoate + UDP-alpha-D-glucose = 4-(indol-3-yl)butanoyl-beta-D-glucose + UDP"}
{"X":43878,"RHEA_ID":52204,"DIRECTION":"UN","MASTER_ID":52204,"ec":"1.14.15.23","compounds":"butachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = butyl formate + H2O + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":43879,"RHEA_ID":42236,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":43880,"RHEA_ID":52206,"compounds":"butyl formate + H2O + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin] => butachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":43881,"RHEA_ID":62712,"compounds":"betaenone C + H(+) + NADPH + O2 = H2O + NADP(+) + stemphyloxin I"}
{"X":43882,"RHEA_ID":42239,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA <=> 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":43883,"RHEA_ID":42240,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + tetradecanoyl-CoA = 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":43884,"RHEA_ID":52210,"compounds":"H2O + methyl formate + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin] => alachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":43885,"RHEA_ID":52211,"compounds":"alachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + methyl formate + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":43886,"RHEA_ID":52212,"compounds":"acetochlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = ethyl formate + H2O + N-(2-ethyl-6-methylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":43887,"RHEA_ID":42244,"compounds":"H(+) + malonyl-[ACP] + propanoyl-CoA = 3-oxopentanoyl-[ACP] + CO2 + CoA"}
{"X":43888,"RHEA_ID":52214,"compounds":"ethyl formate + H2O + N-(2-ethyl-6-methylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin] => acetochlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":43889,"RHEA_ID":42246,"compounds":"3-oxopentanoyl-[ACP] + CO2 + CoA => H(+) + malonyl-[ACP] + propanoyl-CoA"}
{"X":43890,"RHEA_ID":42247,"compounds":"H(+) + malonyl-[ACP] + propanoyl-CoA <=> 3-oxopentanoyl-[ACP] + CO2 + CoA"}
{"X":43891,"RHEA_ID":42248,"compounds":"butanoyl-CoA + H(+) + malonyl-[ACP] = 3-oxohexanoyl-[ACP] + CO2 + CoA"}
{"X":43892,"RHEA_ID":52218,"compounds":"[(1''->2')-ADP-alpha-D-ribose]n-1 + ADP-D-ribose => [(1''->2')-ADP-alpha-D-ribose]n + H2O"}
{"X":43893,"RHEA_ID":52219,"compounds":"[(1''->2')-ADP-alpha-D-ribose]n + H2O <=> [(1''->2')-ADP-alpha-D-ribose]n-1 + ADP-D-ribose"}
{"X":43894,"RHEA_ID":52224,"DIRECTION":"UN","MASTER_ID":52224,"ec":"1.14.99.58","compounds":"3 AH2 + 3 H(+) + heme b + 3 O2 = 3 A + biliverdin delta + CO + Fe(2+) + 3 H2O"}
{"X":43895,"RHEA_ID":42252,"compounds":"H(+) + malonyl-[ACP] + pentanoyl-CoA = 3-oxoheptanoyl-[ACP] + CO2 + CoA"}
{"X":43896,"RHEA_ID":42253,"compounds":"H(+) + malonyl-[ACP] + pentanoyl-CoA => 3-oxoheptanoyl-[ACP] + CO2 + CoA"}
{"X":43897,"RHEA_ID":62728,"compounds":"(+)-malbrancheamide B + bromide + FAD + 2 H(+) = (+)-malbrancheamide D + FADH2"}
{"X":43898,"RHEA_ID":42255,"compounds":"H(+) + malonyl-[ACP] + pentanoyl-CoA <=> 3-oxoheptanoyl-[ACP] + CO2 + CoA"}
{"X":43899,"RHEA_ID":42256,"compounds":"H(+) + hexanoyl-CoA + malonyl-[ACP] = 3-oxooctanoyl-[ACP] + CO2 + CoA"}
{"X":43900,"RHEA_ID":42257,"compounds":"H(+) + hexanoyl-CoA + malonyl-[ACP] => 3-oxooctanoyl-[ACP] + CO2 + CoA"}
{"X":43901,"RHEA_ID":62732,"compounds":"(+)-isomalbrancheamide B + bromide + FAD + 2 H(+) = (+)-isomalbrancheamide D + FADH2"}
{"X":43902,"RHEA_ID":52232,"DIRECTION":"UN","MASTER_ID":52232,"ec":"1.14.99.57","compounds":"3 AH2 + 2 H(+) + heme b + 3 O2 = 3 A + Fe(2+) + 3 H2O + mycobilin a"}
{"X":43903,"RHEA_ID":42260,"compounds":"H(+) + heptanoyl-CoA + malonyl-[ACP] = 3-oxononanoyl-[ACP] + CO2 + CoA"}
{"X":43904,"RHEA_ID":52234,"compounds":"3 A + Fe(2+) + 3 H2O + mycobilin a => 3 AH2 + 2 H(+) + heme b + 3 O2"}
{"X":43905,"RHEA_ID":62736,"compounds":"1-hydroxy-3-(1H-indol-3-ylmethyl)-6H,7H,8H-5lambda5-pyrrolo[1,2-a]pyrazin-5-ylium + dimethylallyl diphosphate = 1-hydroxy-3-{[2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl]methyl}-6H,7H,8H-5lambda5-pyrrolo[1,2-a]pyrazine + diphosphate"}
{"X":43906,"RHEA_ID":52236,"DIRECTION":"UN","MASTER_ID":52236,"ec":"1.14.99.57","compounds":"3 AH2 + 2 H(+) + heme b + 3 O2 = 3 A + Fe(2+) + 3 H2O + mycobilin b"}
{"X":43907,"RHEA_ID":42264,"DIRECTION":"UN","MASTER_ID":42264,"ec":"2.3.1.207","compounds":"H(+) + malonyl-[ACP] + octanoyl-CoA = 3-oxodecanoyl-[ACP] + CO2 + CoA"}
{"X":43908,"RHEA_ID":42265,"DIRECTION":"LR","MASTER_ID":42264,"metacyc":"RXN-13613","compounds":"H(+) + malonyl-[ACP] + octanoyl-CoA => 3-oxodecanoyl-[ACP] + CO2 + CoA"}
{"X":43909,"RHEA_ID":62740,"compounds":"(8aS)-3-[(1H-indol-3-yl)methyl]-1H,2H,6H,7H,8H,8aH-pyrrolo[1,2-a]pyrazin-1-one + A + H(+) = 1-hydroxy-3-(1H-indol-3-ylmethyl)-6H,7H,8H-5lambda5-pyrrolo[1,2-a]pyrazin-5-ylium + AH2"}
{"X":43910,"RHEA_ID":62741,"compounds":"(8aS)-3-[(1H-indol-3-yl)methyl]-1H,2H,6H,7H,8H,8aH-pyrrolo[1,2-a]pyrazin-1-one + A + H(+) => 1-hydroxy-3-(1H-indol-3-ylmethyl)-6H,7H,8H-5lambda5-pyrrolo[1,2-a]pyrazin-5-ylium + AH2"}
{"X":43911,"RHEA_ID":42268,"compounds":"2-methylpropanoyl-CoA + H(+) + malonyl-[ACP] = 3-oxo-4-methylpentanoyl-[ACP] + CO2 + CoA"}
{"X":43912,"RHEA_ID":52242,"compounds":"4 H(+) + 2 MnO2 => 2 H2O + 2 Mn(2+) + O2"}
{"X":43913,"RHEA_ID":42270,"compounds":"3-oxo-4-methylpentanoyl-[ACP] + CO2 + CoA => 2-methylpropanoyl-CoA + H(+) + malonyl-[ACP]"}
{"X":43914,"RHEA_ID":42271,"compounds":"2-methylpropanoyl-CoA + H(+) + malonyl-[ACP] <=> 3-oxo-4-methylpentanoyl-[ACP] + CO2 + CoA"}
{"X":43915,"RHEA_ID":42272,"compounds":"3-methylbutanoyl-CoA + H(+) + malonyl-[ACP] = 3-oxo-5-methylhexanoyl-[ACP] + CO2 + CoA"}
{"X":43916,"RHEA_ID":42273,"compounds":"3-methylbutanoyl-CoA + H(+) + malonyl-[ACP] => 3-oxo-5-methylhexanoyl-[ACP] + CO2 + CoA"}
{"X":43917,"RHEA_ID":42274,"compounds":"3-oxo-5-methylhexanoyl-[ACP] + CO2 + CoA => 3-methylbutanoyl-CoA + H(+) + malonyl-[ACP]"}
{"X":43918,"RHEA_ID":52248,"compounds":"6 H2O + 4 Mn(3+) + O2 = 12 H(+) + 4 MnO2"}
{"X":43919,"RHEA_ID":42276,"compounds":"2-methylbutanoyl-CoA + H(+) + malonyl-[ACP] = 3-oxo-4-methylhexanoyl-[ACP] + CO2 + CoA"}
{"X":43920,"RHEA_ID":52250,"compounds":"12 H(+) + 4 MnO2 => 6 H2O + 4 Mn(3+) + O2"}
{"X":43921,"RHEA_ID":42278,"compounds":"3-oxo-4-methylhexanoyl-[ACP] + CO2 + CoA => 2-methylbutanoyl-CoA + H(+) + malonyl-[ACP]"}
{"X":43922,"RHEA_ID":62765,"compounds":"4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 => 4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":43923,"RHEA_ID":42280,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5Z,8Z,11R,12E,14Z)-11-hydroperoxyeicosatetraenoate"}
{"X":43924,"RHEA_ID":52254,"compounds":"2 5'-deoxyadenosine + a bacteriochlorophyllide e + 2 H(+) + 2 L-methionine => a bacteriochlorophyllide c + H2O + 2 S-adenosyl-L-methionine"}
{"X":43925,"RHEA_ID":42282,"compounds":"(5Z,8Z,11R,12E,14Z)-11-hydroperoxyeicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2"}
{"X":43926,"RHEA_ID":52256,"compounds":"a 7(1)-hydroxybacteriochlorophyllide c + H2O + S-adenosyl-L-methionine = 5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide c + H(+) + L-methionine"}
{"X":43927,"RHEA_ID":42284,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate"}
{"X":43928,"RHEA_ID":62771,"compounds":"4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}
{"X":43929,"RHEA_ID":42286,"compounds":"(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2"}
{"X":43930,"RHEA_ID":52260,"compounds":"a 7(1),7(1)-dihydroxybacteriochlorophyllide c = a bacteriochlorophyllide e + H2O"}
{"X":43931,"RHEA_ID":42288,"DIRECTION":"UN","MASTER_ID":42288,"ec":"2.3.1.47","compounds":"6-carboxyhexanoyl-[ACP] + H(+) + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[ACP]"}
{"X":43932,"RHEA_ID":62779,"compounds":"4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}
{"X":43933,"RHEA_ID":42290,"compounds":"8-amino-7-oxononanoate + CO2 + holo-[ACP] => 6-carboxyhexanoyl-[ACP] + H(+) + L-alanine"}
{"X":43934,"RHEA_ID":52264,"DIRECTION":"UN","MASTER_ID":52264,"ec":"2.1.1.340","compounds":"3-(aminomethyl)indole + 2 S-adenosyl-L-methionine = gramine + 2 H(+) + 2 S-adenosyl-L-homocysteine"}
{"X":43935,"RHEA_ID":42292,"DIRECTION":"UN","MASTER_ID":42292,"ec":"2.3.1.274","compounds":"a fatty acyl-[ACP] + phosphate = an acyl phosphate + holo-[ACP]"}
{"X":43936,"RHEA_ID":52266,"compounds":"gramine + 2 H(+) + 2 S-adenosyl-L-homocysteine => 3-(aminomethyl)indole + 2 S-adenosyl-L-methionine"}
{"X":43937,"RHEA_ID":42294,"compounds":"an acyl phosphate + holo-[ACP] => a fatty acyl-[ACP] + phosphate"}
{"X":43938,"RHEA_ID":52268,"compounds":"3-(aminomethyl)indole + S-adenosyl-L-methionine = (1H-indol-3-yl)-N-methylmethanamine + H(+) + S-adenosyl-L-homocysteine"}
{"X":43939,"RHEA_ID":42296,"DIRECTION":"UN","MASTER_ID":42296,"ec":"2.3.1.n4","compounds":"a 1-acyl-sn-glycero-3-phosphate + a fatty acyl-[ACP] = a 1,2-diacyl-sn-glycero-3-phosphate + holo-[ACP]"}
{"X":43940,"RHEA_ID":55582,"compounds":"AMP + 2 H(+) + N(5)-phospho-L-glutamine + phosphate => ATP + H2O + L-glutamine"}
{"X":43941,"RHEA_ID":42298,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphate + holo-[ACP] => a 1-acyl-sn-glycero-3-phosphate + a fatty acyl-[ACP]"}
{"X":43942,"RHEA_ID":42300,"DIRECTION":"UN","MASTER_ID":42300,"ec":"2.3.1.n5","compounds":"a fatty acyl-[ACP] + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + holo-[ACP]"}
{"X":43943,"RHEA_ID":55586,"compounds":"H(+) + N(6)-methyladenosine in mRNA + S-adenosyl-L-homocysteine => adenosine in mRNA + S-adenosyl-L-methionine"}
{"X":43944,"RHEA_ID":42302,"compounds":"a 1-acyl-sn-glycero-3-phosphate + holo-[ACP] => a fatty acyl-[ACP] + sn-glycerol 3-phosphate"}
{"X":43945,"RHEA_ID":52276,"DIRECTION":"UN","MASTER_ID":52276,"ec":"2.1.1.341","compounds":"(6S)-5,6,7,8-tetrahydrofolate + 4-hydroxy-3-methoxybenzoate = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4-dihydroxybenzoate"}
{"X":43946,"RHEA_ID":42304,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol-3'-phosphate) + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate"}
{"X":43947,"RHEA_ID":45601,"DIRECTION":"LR","MASTER_ID":45600,"metacyc":"RXN-15902","compounds":"D-galactaro-1,4-lactone => 5-dehydro-4-deoxy-D-glucarate + H(+)"}
{"X":43948,"RHEA_ID":42306,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol-3'-phosphate) + H2O"}
{"X":43949,"RHEA_ID":52280,"DIRECTION":"UN","MASTER_ID":52280,"ec":"2.1.1.341","compounds":"(6S)-5,6,7,8-tetrahydrofolate + 3-O-methylgallate = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4,5-trihydroxybenzoate"}
{"X":43950,"RHEA_ID":42308,"compounds":"1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}
{"X":43951,"RHEA_ID":55594,"compounds":"(3R)-3-[(3R)-3-hydroxydecanoyloxy]decanoate + H(+) + 2 holo-[ACP] => 2 (3R)-hydroxydecanoyl-[ACP] + H2O"}
{"X":43952,"RHEA_ID":42310,"compounds":"1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O"}
{"X":43953,"RHEA_ID":52284,"compounds":"(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] = 11-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43954,"RHEA_ID":42312,"DIRECTION":"UN","MASTER_ID":42312,"ec":"1.18.1.6","compounds":"H(+) + NADP(+) + 2 reduced [adrenodoxin] = NADPH + 2 oxidized [adrenodoxin]"}
{"X":43955,"RHEA_ID":52286,"compounds":"11-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":43956,"RHEA_ID":42314,"compounds":"NADPH + 2 oxidized [adrenodoxin] => H(+) + NADP(+) + 2 reduced [adrenodoxin]"}
{"X":43957,"RHEA_ID":52288,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43958,"RHEA_ID":42316,"DIRECTION":"UN","MASTER_ID":42316,"ec":"1.2.7.11","compounds":"a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":43959,"RHEA_ID":52290,"compounds":"7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":43960,"RHEA_ID":42318,"compounds":"an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":43961,"RHEA_ID":52292,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43962,"RHEA_ID":42320,"compounds":"a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}
{"X":43963,"RHEA_ID":52294,"compounds":"13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":43964,"RHEA_ID":52295,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43965,"RHEA_ID":42323,"compounds":"a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O <=> a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}
{"X":43966,"RHEA_ID":42324,"DIRECTION":"UN","MASTER_ID":42324,"ec":"1.5.7.2","compounds":"2 oxidized [2Fe-2S]-[ferredoxin] + reduced coenzyme F420-(gamma-Glu)(n) = 3 H(+) + oxidized coenzyme F420-(gamma-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":43967,"RHEA_ID":52298,"compounds":"10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":43968,"RHEA_ID":52299,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":43969,"RHEA_ID":55616,"DIRECTION":"UN","MASTER_ID":55616,"ec":"5.5.1.18","compounds":"a carotenoid psi-end group = a carotenoid epsilon-end group"}
{"X":43970,"RHEA_ID":42328,"compounds":"1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-3-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}
{"X":43971,"RHEA_ID":52302,"compounds":"(12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":43972,"RHEA_ID":42330,"compounds":"1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => 1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-3-phosphate) + H2O"}
{"X":43973,"RHEA_ID":52304,"DIRECTION":"UN","MASTER_ID":52304,"ec":"3.5.4.44","compounds":"H2O + L-ectoine = (2S)-2-acetamido-4-aminobutanoate"}
{"X":43974,"RHEA_ID":42332,"DIRECTION":"UN","MASTER_ID":42332,"ec":"6.3.2.32","compounds":"ATP + L-glutamate + oxidized coenzyme F420-2 = ADP + H(+) + oxidized coenzyme alpha-F420-3 + phosphate"}
{"X":43975,"RHEA_ID":52306,"compounds":"(2S)-2-acetamido-4-aminobutanoate => H2O + L-ectoine"}
{"X":43976,"RHEA_ID":45630,"compounds":"holo-[CmaA peptidyl-carrier protein] + L-alloisoleucyl-[CmaD peptidyl-carrier protein] => holo-[CmaD peptidyl-carrier protein] + L-alloisoleucyl-[CmaA peptidyl-carrier protein]"}
{"X":43977,"RHEA_ID":45631,"DIRECTION":"BI","MASTER_ID":45628,"metacyc":"RXN-16277","compounds":"holo-[CmaD peptidyl-carrier protein] + L-alloisoleucyl-[CmaA peptidyl-carrier protein] <=> holo-[CmaA peptidyl-carrier protein] + L-alloisoleucyl-[CmaD peptidyl-carrier protein]"}
{"X":43978,"RHEA_ID":42336,"DIRECTION":"UN","MASTER_ID":42336,"ec":"1.8.7.2","compounds":"[thioredoxin]-disulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = [thioredoxin]-dithiol + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":43979,"RHEA_ID":52310,"compounds":"2-oxoglutarate + H(+) + NADPH => 2-hydroxyglutarate + NADP(+)"}
{"X":43980,"RHEA_ID":52311,"compounds":"2-hydroxyglutarate + NADP(+) <=> 2-oxoglutarate + H(+) + NADPH"}
{"X":43981,"RHEA_ID":42340,"DIRECTION":"UN","MASTER_ID":42340,"ec":"1.2.1.99","compounds":"4-(gamma-L-glutamylamino)butanal + H2O + NAD(+) = 4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADH"}
{"X":43982,"RHEA_ID":42341,"DIRECTION":"LR","MASTER_ID":42340,"ecocyc":"RXN0-3922","metacyc":"RXN0-3922","compounds":"4-(gamma-L-glutamylamino)butanal + H2O + NAD(+) => 4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADH"}
{"X":43983,"RHEA_ID":52315,"compounds":"NAD(+) + thromboxane B2 <=> 11-dehydro-thromboxane B2 + H(+) + NADH"}
{"X":43984,"RHEA_ID":52316,"DIRECTION":"UN","MASTER_ID":52316,"ec":"2.4.99.6","compounds":"a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+)"}
{"X":43985,"RHEA_ID":42344,"DIRECTION":"UN","MASTER_ID":42344,"ec":"1.14.12.25","compounds":"H(+) + NADH + O2 + p-cumate = (2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+)"}
{"X":43986,"RHEA_ID":52318,"compounds":"an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+) => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate"}
{"X":43987,"RHEA_ID":45642,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O"}
{"X":43988,"RHEA_ID":55644,"compounds":"ATP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] = ADP + C-terminal S-cyanate-L-cysteinyl-[HypE protein] + H(+) + phosphate"}
{"X":43989,"RHEA_ID":42348,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + ADP + H(+)"}
{"X":43990,"RHEA_ID":52322,"compounds":"H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + serotonin => O2 + reduced [NADPH--hemoprotein reductase] + tryptamine"}
{"X":43991,"RHEA_ID":52323,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + tryptamine <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + serotonin"}
{"X":43992,"RHEA_ID":52324,"DIRECTION":"UN","MASTER_ID":52324,"ec":"1.14.14.47","compounds":"2 L-arginine + 4 O2 + 3 reduced [flavodoxin] = 5 H(+) + 4 H2O + 2 L-citrulline + 2 nitric oxide + 3 oxidized [flavodoxin]"}
{"X":43993,"RHEA_ID":42352,"DIRECTION":"UN","MASTER_ID":42352,"ec":"1.5.99.4","compounds":"(R)-nicotine + A + H2O = (R)-6-hydroxynicotine + AH2"}
{"X":43994,"RHEA_ID":45649,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}
{"X":43995,"RHEA_ID":55651,"compounds":"2-oxoglutarate + O2 + validoxylamine A <=> CO2 + H(+) + succinate + validoxylamine B"}
{"X":43996,"RHEA_ID":45651,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}
{"X":43997,"RHEA_ID":42356,"compounds":"(9Z)-tetradecenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(11Z)-hexadecenoyl-CoA + CO2 + CoA"}
{"X":43998,"RHEA_ID":42357,"compounds":"(9Z)-tetradecenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(11Z)-hexadecenoyl-CoA + CO2 + CoA"}
{"X":43999,"RHEA_ID":42358,"compounds":"3-oxo-(11Z)-hexadecenoyl-CoA + CO2 + CoA => (9Z)-tetradecenoyl-CoA + H(+) + malonyl-CoA"}
{"X":44000,"RHEA_ID":52332,"compounds":"2 N(omega)-hydroxy-L-arginine + 2 O2 + reduced [flavodoxin] = 3 H(+) + 2 H2O + 2 L-citrulline + 2 nitric oxide + oxidized [flavodoxin]"}
{"X":44001,"RHEA_ID":42360,"DIRECTION":"UN","MASTER_ID":42360,"ec":"5.1.3.30","compounds":"D-allulose = keto-D-fructose"}
{"X":44002,"RHEA_ID":42360,"DIRECTION":"UN","MASTER_ID":42360,"ec":"5.1.3.31","compounds":"D-allulose = keto-D-fructose"}
{"X":44003,"RHEA_ID":55659,"compounds":"2 A + a carotenoid beta-end derivative <=> a carotenoid chi-end derivative + 2 AH2"}
{"X":44004,"RHEA_ID":52336,"compounds":"a long-chain fatty acid + ATP + H(+) = a long-chain acyl-AMP + diphosphate"}
{"X":44005,"RHEA_ID":52337,"DIRECTION":"LR","MASTER_ID":52336,"metacyc":"RXN-17251","compounds":"a long-chain fatty acid + ATP + H(+) => a long-chain acyl-AMP + diphosphate"}
{"X":44006,"RHEA_ID":42364,"compounds":"2 a 2-acyl-sn-glycero-3-phosphocholine = a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine"}
{"X":44007,"RHEA_ID":52339,"compounds":"a long-chain fatty acid + ATP + H(+) <=> a long-chain acyl-AMP + diphosphate"}
{"X":44008,"RHEA_ID":42366,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine => 2 a 2-acyl-sn-glycero-3-phosphocholine"}
{"X":44009,"RHEA_ID":42367,"compounds":"2 a 2-acyl-sn-glycero-3-phosphocholine <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine"}
{"X":44010,"RHEA_ID":42368,"DIRECTION":"UN","MASTER_ID":42368,"ec":"1.14.14.124","compounds":"dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + monacolin L carboxylate + oxidized [NADPH--hemoprotein reductase]"}
{"X":44011,"RHEA_ID":52343,"compounds":"a holo-[mycocerosate synthase] + a long-chain acyl-AMP <=> a long-chain acyl-[mycocerosate synthase] + AMP + H(+)"}
{"X":44012,"RHEA_ID":52344,"compounds":"(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate = (24S)-hydroxycholesterol 24-sulfate + adenosine 3',5'-bisphosphate + H(+)"}
{"X":44013,"RHEA_ID":52345,"compounds":"(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate => (24S)-hydroxycholesterol 24-sulfate + adenosine 3',5'-bisphosphate + H(+)"}
{"X":44014,"RHEA_ID":42372,"compounds":"16-methoxytabersonine + H2O = (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine"}
{"X":44015,"RHEA_ID":52347,"compounds":"(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate <=> (24S)-hydroxycholesterol 24-sulfate + adenosine 3',5'-bisphosphate + H(+)"}
{"X":44016,"RHEA_ID":42374,"compounds":"(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine => 16-methoxytabersonine + H2O"}
{"X":44017,"RHEA_ID":52349,"compounds":"(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate => (24S)-hydroxycholesterol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)"}
{"X":44018,"RHEA_ID":52350,"compounds":"(24S)-hydroxycholesterol 3-sulfate + adenosine 3',5'-bisphosphate + H(+) => (24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate"}
{"X":44019,"RHEA_ID":52351,"compounds":"(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate <=> (24S)-hydroxycholesterol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)"}
{"X":44020,"RHEA_ID":42378,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O"}
{"X":44021,"RHEA_ID":42379,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + phosphate"}
{"X":44022,"RHEA_ID":42380,"DIRECTION":"UN","MASTER_ID":42380,"ec":"1.2.99.10","compounds":"2 A + all-trans-4,4'-diapolycopene-4,4'-dial + 2 H2O = 2 AH2 + all-trans-4,4'-diapolycopene-4,4'-dioate + 2 H(+)"}
{"X":44023,"RHEA_ID":52355,"compounds":"(24S)-hydroxycholesterol 24-sulfate + 3'-phosphoadenylyl sulfate <=> (24S)-hydroxycholesterol 3,24-disulfate + adenosine 3',5'-bisphosphate + H(+)"}
{"X":44024,"RHEA_ID":42382,"compounds":"2 AH2 + all-trans-4,4'-diapolycopene-4,4'-dioate + 2 H(+) => 2 A + all-trans-4,4'-diapolycopene-4,4'-dial + 2 H2O"}
{"X":44025,"RHEA_ID":52357,"DIRECTION":"LR","MASTER_ID":52356,"reactome":"R-HSA-176517.2","compounds":"3'-phosphoadenylyl sulfate + pregnenolone => adenosine 3',5'-bisphosphate + H(+) + pregnenolone sulfate"}
{"X":44026,"RHEA_ID":52358,"compounds":"adenosine 3',5'-bisphosphate + H(+) + pregnenolone sulfate => 3'-phosphoadenylyl sulfate + pregnenolone"}
{"X":44027,"RHEA_ID":42385,"DIRECTION":"LR","MASTER_ID":42384,"metacyc":"RXN-9307","compounds":"4,4'-diaponeurosporenal + H2O + NAD(+) => 4,4'-diaponeurosporenoate + 2 H(+) + NADH"}
{"X":44028,"RHEA_ID":42386,"compounds":"4,4'-diaponeurosporenoate + 2 H(+) + NADH => 4,4'-diaponeurosporenal + H2O + NAD(+)"}
{"X":44029,"RHEA_ID":42387,"compounds":"4,4'-diaponeurosporenal + H2O + NAD(+) <=> 4,4'-diaponeurosporenoate + 2 H(+) + NADH"}
{"X":44030,"RHEA_ID":52370,"compounds":"adenosine 3',5'-bisphosphate + cholesterol sulfate + H(+) => 3'-phosphoadenylyl sulfate + cholesterol"}
{"X":44031,"RHEA_ID":45686,"compounds":"N-(dodecanoyl)-sphing-4-enine-1-phosphate(out) => N-(dodecanoyl)-sphing-4-enine-1-phosphate(in)"}
{"X":44032,"RHEA_ID":42390,"compounds":"beta-D-gentiobiosyl crocetin + H(+) + UDP => beta-D-glucosyl crocetin + UDP-alpha-D-glucose"}
{"X":44033,"RHEA_ID":52373,"DIRECTION":"LR","MASTER_ID":52372,"reactome":"R-HSA-176521.2","compounds":"17beta-estradiol + 3'-phosphoadenylyl sulfate => 17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)"}
{"X":44034,"RHEA_ID":42392,"DIRECTION":"UN","MASTER_ID":42392,"ec":"1.1.1.359","compounds":"D-galactose + NAD(+) = D-galactono-1,5-lactone + H(+) + NADH"}
{"X":44035,"RHEA_ID":52375,"compounds":"17beta-estradiol + 3'-phosphoadenylyl sulfate <=> 17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)"}
{"X":44036,"RHEA_ID":42394,"compounds":"D-galactono-1,5-lactone + H(+) + NADH => D-galactose + NAD(+)"}
{"X":44037,"RHEA_ID":52377,"DIRECTION":"LR","MASTER_ID":52376,"metacyc":"RXN-18466","compounds":"(+)-sesamin monocatechol + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n => (+)-sesamin dicatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n)"}
{"X":44038,"RHEA_ID":45693,"compounds":"N-(octanoyl)-sphing-4-enine-1-phosphate(in) => N-(octanoyl)-sphing-4-enine-1-phosphate(out)"}
{"X":44039,"RHEA_ID":48996,"compounds":"3-methylcatechol + O2 = 2-hydroxy-6-oxo-2,4-heptadienoate + H(+)"}
{"X":44040,"RHEA_ID":42398,"compounds":"2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 H(+) + 2 S-adenosyl-L-homocysteine => cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine"}
{"X":44041,"RHEA_ID":42399,"compounds":"cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine <=> 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 H(+) + 2 S-adenosyl-L-homocysteine"}
{"X":44042,"RHEA_ID":52382,"compounds":"an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+) => a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate"}
{"X":44043,"RHEA_ID":49000,"DIRECTION":"UN","MASTER_ID":49000,"ec":"1.14.13.222","compounds":"aurachin C + H(+) + NADH + O2 = 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NAD(+)"}
{"X":44044,"RHEA_ID":42402,"compounds":"L-histidyl-[protein] + lactose 6-phosphate(in) => lactose(out) + N(pros)-phospho-L-histidyl-[protein]"}
{"X":44045,"RHEA_ID":52385,"DIRECTION":"LR","MASTER_ID":52384,"metacyc":"RXN-18395","compounds":"L-glutamate + O-phospho-L-serine => H(+) + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + phosphate"}
{"X":44046,"RHEA_ID":52386,"compounds":"H(+) + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + phosphate => L-glutamate + O-phospho-L-serine"}
{"X":44047,"RHEA_ID":55715,"compounds":"(S,S)-3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O <=> (9Z)-octadecenoate + (S,S)-3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+)"}
{"X":44048,"RHEA_ID":42406,"compounds":"beta-D-glucose + D-galactose 6-phosphate => H2O + lactose 6-phosphate"}
{"X":44049,"RHEA_ID":52389,"DIRECTION":"LR","MASTER_ID":52388,"metacyc":"RXN-18596","compounds":"ATP + D-threonate => 4-O-phospho-D-threonate + ADP + H(+)"}
{"X":44050,"RHEA_ID":52390,"compounds":"4-O-phospho-D-threonate + ADP + H(+) => ATP + D-threonate"}
{"X":44051,"RHEA_ID":45706,"DIRECTION":"RL","MASTER_ID":45704,"metacyc":"RXN-1125","compounds":"(E)-sinapoaldehyde + H(+) + NADPH => (E)-sinapoyl alcohol + NADP(+)"}
{"X":44052,"RHEA_ID":42410,"compounds":"(2R)-2,3-bisphosphoglycerate + ADP + H(+) => (2R)-2-phosphoglycerate + ATP"}
{"X":44053,"RHEA_ID":52393,"DIRECTION":"LR","MASTER_ID":52392,"metacyc":"RXN-18597","compounds":"ATP + D-erythronate => 4-phospho-D-erythronate + ADP + H(+)"}
{"X":44054,"RHEA_ID":45709,"compounds":"3-dehydrocarnitine + acetyl-CoA => 3-dehydrocarnityl-CoA + acetate"}
{"X":44055,"RHEA_ID":59051,"compounds":"D-ornithine + H(+) <=> CO2 + putrescine"}
{"X":44056,"RHEA_ID":42414,"compounds":"ADP + cyclic (2R)-2,3-bisphosphoglycerate + phosphate => (2R)-2,3-bisphosphoglycerate + ATP + H(+)"}
{"X":44057,"RHEA_ID":52397,"DIRECTION":"LR","MASTER_ID":52396,"metacyc":"RXN-18600","compounds":"4-O-phospho-D-threonate + NAD(+) => CO2 + dihydroxyacetone phosphate + NADH"}
{"X":44058,"RHEA_ID":42416,"DIRECTION":"UN","MASTER_ID":42416,"ec":"1.5.5.2","compounds":"a ubiquinone + L-proline = (S)-1-pyrroline-5-carboxylate + a ubiquinol + H(+)"}
{"X":44059,"RHEA_ID":49016,"compounds":"aurachin C epoxide = 2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one"}
{"X":44060,"RHEA_ID":42418,"compounds":"(S)-1-pyrroline-5-carboxylate + a ubiquinol + H(+) => a ubiquinone + L-proline"}
{"X":44061,"RHEA_ID":42419,"compounds":"a ubiquinone + L-proline <=> (S)-1-pyrroline-5-carboxylate + a ubiquinol + H(+)"}
{"X":44062,"RHEA_ID":52402,"compounds":"3-dehydro-4-O-phospho-L-erythronate + H(+) + NADH => 4-O-phospho-D-threonate + NAD(+)"}
{"X":44063,"RHEA_ID":49020,"compounds":"2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one = 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide"}
{"X":44064,"RHEA_ID":42422,"compounds":"(4R)-4-hydroxy-L-lysine + CO2 + succinate => 2-oxoglutarate + L-lysine + O2"}
{"X":44065,"RHEA_ID":42423,"compounds":"2-oxoglutarate + L-lysine + O2 <=> (4R)-4-hydroxy-L-lysine + CO2 + succinate"}
{"X":44066,"RHEA_ID":45721,"compounds":"N-hexadecanoylsphing-4-enine(in) => N-hexadecanoylsphing-4-enine(out)"}
{"X":44067,"RHEA_ID":45722,"compounds":"N-hexadecanoylsphing-4-enine(out) => N-hexadecanoylsphing-4-enine(in)"}
{"X":44068,"RHEA_ID":42426,"compounds":"(2R,3S)-3-methylmalate => 2-methylmaleate + H2O"}
{"X":44069,"RHEA_ID":52409,"DIRECTION":"LR","MASTER_ID":52408,"metacyc":"RXN-18601","compounds":"4-phospho-D-erythronate + NAD(+) => CO2 + dihydroxyacetone phosphate + NADH"}
{"X":44070,"RHEA_ID":52410,"compounds":"CO2 + dihydroxyacetone phosphate + NADH => 4-phospho-D-erythronate + NAD(+)"}
{"X":44071,"RHEA_ID":45726,"DIRECTION":"RL","MASTER_ID":45724,"metacyc":"RXN-1102","compounds":"(E)-4-coumaraldehyde + H(+) + NADPH => (E)-4-coumaroyl alcohol + NADP(+)"}
{"X":44072,"RHEA_ID":42430,"compounds":"(3R,5R)-clavulanate-9-aldehyde => clavaminate"}
{"X":44073,"RHEA_ID":52413,"DIRECTION":"LR","MASTER_ID":52412,"metacyc":"RXN-18598","compounds":"4-phospho-D-erythronate + NAD(+) => 3-dehydro-4-O-phospho-D-erythronate + H(+) + NADH"}
{"X":44074,"RHEA_ID":42432,"compounds":"3-hydroxy-cis,cis-muconate = maleylacetate"}
{"X":44075,"RHEA_ID":45730,"compounds":"(E)-caffeyl aldehyde + H(+) + NADPH => (E)-caffeyl alcohol + NADP(+)"}
{"X":44076,"RHEA_ID":42434,"compounds":"maleylacetate => 3-hydroxy-cis,cis-muconate"}
{"X":44077,"RHEA_ID":55745,"compounds":"coenzyme B + coenzyme M + 4 H(+) + 2 oxidized coenzyme F420-(gamma-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin] => coenzyme M-coenzyme B heterodisulfide + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 reduced coenzyme F420-(gamma-Glu)(n)"}
{"X":44078,"RHEA_ID":42436,"DIRECTION":"UN","MASTER_ID":42436,"ec":"2.7.1.194","compounds":"L-ascorbate(out) + N(pros)-phospho-L-histidyl-[protein] = L-ascorbate 6-phosphate(in) + L-histidyl-[protein]"}
{"X":44079,"RHEA_ID":45734,"compounds":"(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate => D-ribulose 5-phosphate + L-tyrosine"}
{"X":44080,"RHEA_ID":42438,"compounds":"L-ascorbate 6-phosphate(in) + L-histidyl-[protein] => L-ascorbate(out) + N(pros)-phospho-L-histidyl-[protein]"}
{"X":44081,"RHEA_ID":55749,"compounds":"coenzyme B + coenzyme M + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => coenzyme M-coenzyme B heterodisulfide + 2 H2 + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":44082,"RHEA_ID":52422,"compounds":"phosphate + S-sulfo-L-cysteine => O-phospho-L-serine + thiosulfate"}
{"X":44083,"RHEA_ID":45738,"compounds":"(2E)-hexenoyl-CoA => (3E)-hexenoyl-CoA"}
{"X":44084,"RHEA_ID":42442,"compounds":"H(+) + iminosuccinate + NADH => L-aspartate + NAD(+)"}
{"X":44085,"RHEA_ID":55753,"compounds":"2 CO2 + coenzyme B + coenzyme M + 2 reduced [2Fe-2S]-[ferredoxin] => coenzyme M-coenzyme B heterodisulfide + 2 formate + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":44086,"RHEA_ID":42444,"compounds":"L-aspartate + NADP(+) = H(+) + iminosuccinate + NADPH"}
{"X":44087,"RHEA_ID":45742,"compounds":"5-hydroxyectoine + CO2 + succinate => 2-oxoglutarate + L-ectoine + O2"}
{"X":44088,"RHEA_ID":42446,"compounds":"H(+) + iminosuccinate + NADPH => L-aspartate + NADP(+)"}
{"X":44089,"RHEA_ID":55757,"DIRECTION":"LR","MASTER_ID":55756,"metacyc":"RXN-18677","compounds":"2-oxoglutarate + an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + O2 => a 2-hydroxyornithine lipid + CO2 + succinate"}
{"X":44090,"RHEA_ID":42448,"DIRECTION":"UN","MASTER_ID":42448,"ec":"4.2.1.167","compounds":"(R)-2-hydroxyglutaryl-CoA = (2E)-glutaconyl-CoA + H2O"}
{"X":44091,"RHEA_ID":45746,"compounds":"7,8-dihydropteroate + H(+) + NADH => (6S)-5,6,7,8-tetrahydropteroate + NAD(+)"}
{"X":44092,"RHEA_ID":42450,"compounds":"(2E)-glutaconyl-CoA + H2O => (R)-2-hydroxyglutaryl-CoA"}
{"X":44093,"RHEA_ID":55761,"DIRECTION":"LR","MASTER_ID":55760,"metacyc":"RXN-12432","compounds":"a fatty acyl-[ACP] + a lyso-ornithine lipid => an N(2)-[(3R)-3-(acyloxy)acyl]-L-ornithine lipid + holo-[ACP]"}
{"X":44094,"RHEA_ID":42452,"compounds":"4-(2-aminophenyl)-2,4-dioxobutanoate = H2O + kynurenate"}
{"X":44095,"RHEA_ID":45750,"compounds":"(2E)-hexenoyl-CoA => (3Z)-hexenoyl-CoA"}
{"X":44096,"RHEA_ID":42453,"DIRECTION":"LR","MASTER_ID":42452,"ecocyc":"RXN-10720","metacyc":"RXN-10720","reactome":"R-HSA-893609.1","compounds":"4-(2-aminophenyl)-2,4-dioxobutanoate => H2O + kynurenate"}
{"X":44097,"RHEA_ID":42454,"compounds":"H2O + kynurenate => 4-(2-aminophenyl)-2,4-dioxobutanoate"}
{"X":44098,"RHEA_ID":52438,"compounds":"2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + CoA => a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + an acyl-CoA"}
{"X":44099,"RHEA_ID":45754,"compounds":"(2E)-decenoyl-CoA => (3E)-decenoyl-CoA"}
{"X":44100,"RHEA_ID":42457,"compounds":"4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol => 5alpha-cholesta-8,24-dien-3beta-ol"}
{"X":44101,"RHEA_ID":52441,"compounds":"1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1->2)-D-myo-inositol] + GDP-alpha-D-mannose => a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+)"}
{"X":44102,"RHEA_ID":45758,"compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O2 + sarcosine => (6S)-5,6,7,8-tetrahydrofolate + N,N-dimethylglycine + O2"}
{"X":44103,"RHEA_ID":42461,"DIRECTION":"LR","MASTER_ID":42460,"metacyc":"R606-RXN","compounds":"dibenzofuran + H(+) + NADH + O2 => biphenyl-2,2',3-triol + NAD(+)"}
{"X":44104,"RHEA_ID":52445,"compounds":"1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1->2)-D-myo-inositol] + GDP-alpha-D-mannose => 2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+)"}
{"X":44105,"RHEA_ID":52446,"compounds":"2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+) => 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1->2)-D-myo-inositol] + GDP-alpha-D-mannose"}
{"X":44106,"RHEA_ID":52447,"compounds":"1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1->2)-D-myo-inositol] + GDP-alpha-D-mannose <=> 2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+)"}
{"X":44107,"RHEA_ID":42465,"DIRECTION":"LR","MASTER_ID":42464,"metacyc":"R607-RXN","compounds":"biphenyl-2,2',3-triol + O2 => 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + 2 H(+)"}
{"X":44108,"RHEA_ID":52449,"compounds":"16alpha-hydroxyestrone + UDP-alpha-D-glucuronate => 16alpha-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":44109,"RHEA_ID":52450,"compounds":"16alpha-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha-hydroxyestrone + UDP-alpha-D-glucuronate"}
{"X":44110,"RHEA_ID":52451,"compounds":"16alpha-hydroxyestrone + UDP-alpha-D-glucuronate <=> 16alpha-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":44111,"RHEA_ID":42469,"DIRECTION":"LR","MASTER_ID":42468,"metacyc":"R608-RXN","compounds":"2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O => 2-oxopent-4-enoate + salicylate"}
{"X":44112,"RHEA_ID":52453,"compounds":"16alpha-hydroxyestrone + UDP-alpha-D-glucuronate => 16alpha-hydroxyestrone 16-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":44113,"RHEA_ID":52454,"compounds":"16alpha-hydroxyestrone 16-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha-hydroxyestrone + UDP-alpha-D-glucuronate"}
{"X":44114,"RHEA_ID":45770,"compounds":"L-alaninol + L-glutamate => gamma-glutamyl-L-alaninol + H2O"}
{"X":44115,"RHEA_ID":42473,"compounds":"dibenzo-p-dioxin + NADH + O2 => 2,2',3-trihydroxydiphenyl ether + H(+) + NAD(+)"}
{"X":44116,"RHEA_ID":42474,"compounds":"2,2',3-trihydroxydiphenyl ether + H(+) + NAD(+) => dibenzo-p-dioxin + NADH + O2"}
{"X":44117,"RHEA_ID":52458,"compounds":"H(+) + testosterone 17-O-(beta-D-glucuronate) + UDP => testosterone + UDP-alpha-D-glucuronate"}
{"X":44118,"RHEA_ID":45774,"compounds":"[(1->4)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate => [(1->4)-beta-D-mannosyl](n) + phosphate"}
{"X":44119,"RHEA_ID":42477,"DIRECTION":"LR","MASTER_ID":42476,"metacyc":"R604-RXN","compounds":"2,2',3-trihydroxydiphenyl ether + H(+) + O2 => 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate"}
{"X":44120,"RHEA_ID":52461,"compounds":"17beta-estradiol + UDP-alpha-D-glucuronate => 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":44121,"RHEA_ID":52462,"compounds":"17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP => 17beta-estradiol + UDP-alpha-D-glucuronate"}
{"X":44122,"RHEA_ID":45778,"compounds":"(indol-3-yl)acetate + NH4(+) => (indol-3-yl)acetonitrile + 2 H2O"}
{"X":44123,"RHEA_ID":42481,"DIRECTION":"LR","MASTER_ID":42480,"metacyc":"R605-RXN","compounds":"2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O => (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + catechol + H(+)"}
{"X":44124,"RHEA_ID":52465,"compounds":"17beta-estradiol + UDP-alpha-D-glucuronate => 17beta-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":44125,"RHEA_ID":52466,"compounds":"17beta-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP => 17beta-estradiol + UDP-alpha-D-glucuronate"}
{"X":44126,"RHEA_ID":45782,"compounds":"1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + di-(9Z)-octadecenoylglycerol"}
{"X":44127,"RHEA_ID":42485,"DIRECTION":"LR","MASTER_ID":42484,"ecocyc":"TRANS-RXN-169","metacyc":"TRANS-RXN-169","compounds":"D-sorbitol(out) + N(pros)-phospho-L-histidyl-[protein] => D-sorbitol 6-phosphate(in) + L-histidyl-[protein]"}
{"X":44128,"RHEA_ID":52469,"compounds":"16alpha,17beta-estriol + UDP-alpha-D-glucuronate => 16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":44129,"RHEA_ID":52470,"compounds":"16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha,17beta-estriol + UDP-alpha-D-glucuronate"}
{"X":44130,"RHEA_ID":52471,"compounds":"16alpha,17beta-estriol + UDP-alpha-D-glucuronate <=> 16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":44131,"RHEA_ID":42489,"DIRECTION":"LR","MASTER_ID":42488,"metacyc":"RXN-8857","compounds":"(3R)-3-amino-3-phenylpropanoyl-CoA + baccatin III => 3'-N-debenzoyl-2'-deoxytaxol + CoA"}
{"X":44132,"RHEA_ID":52473,"compounds":"16alpha,17beta-estriol + UDP-alpha-D-glucuronate => 16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":44133,"RHEA_ID":52474,"compounds":"16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha,17beta-estriol + UDP-alpha-D-glucuronate"}
{"X":44134,"RHEA_ID":45790,"compounds":"1,2-dihexadecanoyl-3-(9Z-hexadecenoyl)-sn-glycerol + CoA => (9Z)-hexadecenoyl-CoA + 1,2-dihexadecanoyl-sn-glycerol"}
{"X":44135,"RHEA_ID":42493,"DIRECTION":"LR","MASTER_ID":42492,"metacyc":"RXN-11851","compounds":"3'-N-debenzoyl-2'-deoxytaxol + AH2 + O2 => 3'-N-debenzoyltaxol + A + H2O"}
{"X":44136,"RHEA_ID":52477,"compounds":"estrone + UDP-alpha-D-glucuronate => estrone 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":44137,"RHEA_ID":52478,"compounds":"estrone 3-O-(beta-D-glucuronate) + H(+) + UDP => estrone + UDP-alpha-D-glucuronate"}
{"X":44138,"RHEA_ID":52479,"compounds":"estrone + UDP-alpha-D-glucuronate <=> estrone 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":44139,"RHEA_ID":42497,"DIRECTION":"LR","MASTER_ID":42496,"metacyc":"RXN-8865","compounds":"10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate => 10-deacetyl-2-debenzoylbaccatin III"}
{"X":44140,"RHEA_ID":42498,"compounds":"10-deacetyl-2-debenzoylbaccatin III => 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate"}
{"X":44141,"RHEA_ID":45797,"compounds":"(3R)-hydroxybutanoyl-CoA + NADP(+) => acetoacetyl-CoA + H(+) + NADPH"}
{"X":44142,"RHEA_ID":45798,"DIRECTION":"RL","MASTER_ID":45796,"metacyc":"RXN-5901","compounds":"acetoacetyl-CoA + H(+) + NADPH => (3R)-hydroxybutanoyl-CoA + NADP(+)"}
{"X":44143,"RHEA_ID":42501,"compounds":"(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) => 6-lactoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH"}
{"X":44144,"RHEA_ID":52485,"compounds":"(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + A => (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + AH2"}
{"X":44145,"RHEA_ID":45801,"compounds":"15-demethylaclacinomycin T + AH2 + O2 => 10-decarboxymethylaclacinomycin T + A + CO2 + H2O"}
{"X":44146,"RHEA_ID":45802,"compounds":"10-decarboxymethylaclacinomycin T + A + CO2 + H2O => 15-demethylaclacinomycin T + AH2 + O2"}
{"X":44147,"RHEA_ID":42505,"compounds":"2-oxoglutarate + N(6)-acetyl-L-lysine => 6-acetamido-2-oxohexanoate + L-glutamate"}
{"X":44148,"RHEA_ID":52489,"compounds":"O2 + prostaglandin E2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy prostaglandin E2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":44149,"RHEA_ID":52490,"compounds":"20-hydroxy prostaglandin E2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + prostaglandin E2 + reduced [NADPH--hemoprotein reductase]"}
{"X":44150,"RHEA_ID":52491,"compounds":"O2 + prostaglandin E2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy prostaglandin E2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":44151,"RHEA_ID":42509,"DIRECTION":"LR","MASTER_ID":42508,"metacyc":"KETAMID-RXN","compounds":"6-acetamido-2-oxohexanoate + H2O + NAD(+) => 5-acetamidopentanoate + CO2 + H(+) + NADH"}
{"X":44152,"RHEA_ID":52493,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":44153,"RHEA_ID":52494,"compounds":"(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":44154,"RHEA_ID":52495,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":44155,"RHEA_ID":42513,"DIRECTION":"LR","MASTER_ID":42512,"metacyc":"AMVAL-RXN","compounds":"5-acetamidopentanoate + H2O => 5-aminopentanoate + acetate"}
{"X":44156,"RHEA_ID":42514,"compounds":"5-aminopentanoate + acetate => 5-acetamidopentanoate + H2O"}
{"X":44157,"RHEA_ID":52498,"compounds":"(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":44158,"RHEA_ID":45814,"compounds":"a very-long-chain (2E)-enoyl-CoA + H2O => a very-long-chain (3R)-hydroxyacyl-CoA"}
{"X":44159,"RHEA_ID":42517,"DIRECTION":"LR","MASTER_ID":42516,"metacyc":"RXN-8783","compounds":"H2O + L-gulono-1,4-lactone => H(+) + L-gulonate"}
{"X":44160,"RHEA_ID":42518,"compounds":"H(+) + L-gulonate => H2O + L-gulono-1,4-lactone"}
{"X":44161,"RHEA_ID":52502,"compounds":"(13R)-hydroxy-(9Z,11E)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":44162,"RHEA_ID":45818,"compounds":"AH2 + pyruvate => (S)-lactate + A"}
{"X":44163,"RHEA_ID":42521,"DIRECTION":"LR","MASTER_ID":42520,"ecocyc":"RXN-11836","metacyc":"RXN-11836","compounds":"23S rRNA uridine(2605) => 23S rRNA pseudouridine(2605)"}
{"X":44164,"RHEA_ID":42522,"compounds":"23S rRNA pseudouridine(2605) => 23S rRNA uridine(2605)"}
{"X":44165,"RHEA_ID":45821,"DIRECTION":"LR","MASTER_ID":45820,"metacyc":"RXN-12168","compounds":"mesaconate + succinyl-CoA => 2-methylfumaryl-CoA + succinate"}
{"X":44166,"RHEA_ID":45822,"compounds":"2-methylfumaryl-CoA + succinate => mesaconate + succinyl-CoA"}
{"X":44167,"RHEA_ID":42525,"DIRECTION":"LR","MASTER_ID":42524,"ecocyc":"RXN-11837","metacyc":"RXN-11837","compounds":"uridine(1911/1915/1917) in 23S rRNA => pseudouridine(1911/1915/1917) in 23S rRNA"}
{"X":44168,"RHEA_ID":42526,"compounds":"pseudouridine(1911/1915/1917) in 23S rRNA => uridine(1911/1915/1917) in 23S rRNA"}
{"X":44169,"RHEA_ID":42527,"compounds":"uridine(1911/1915/1917) in 23S rRNA <=> pseudouridine(1911/1915/1917) in 23S rRNA"}
{"X":44170,"RHEA_ID":45826,"compounds":"CO2 + ethanolamine => H(+) + L-serine"}
{"X":44171,"RHEA_ID":42529,"DIRECTION":"LR","MASTER_ID":42528,"ecocyc":"RXN-11838","metacyc":"RXN-11838","compounds":"uridine(955/2504/2580) in 23S rRNA => pseudouridine(955/2504/2580) in 23S rRNA"}
{"X":44172,"RHEA_ID":55841,"compounds":"calcidiol + UDP-alpha-D-glucuronate => calcidiol 25-O-(beta-D-glucuronide) + H(+) + UDP"}
{"X":44173,"RHEA_ID":45829,"compounds":"(3R)-hydroxyhexanoyl-CoA + NAD(+) => 3-oxohexanoyl-CoA + H(+) + NADH"}
{"X":44174,"RHEA_ID":45830,"compounds":"3-oxohexanoyl-CoA + H(+) + NADH => (3R)-hydroxyhexanoyl-CoA + NAD(+)"}
{"X":44175,"RHEA_ID":42533,"DIRECTION":"LR","MASTER_ID":42532,"ecocyc":"RXN-11839","metacyc":"RXN-11839","compounds":"uridine(55) in tRNA => pseudouridine(55) in tRNA"}
{"X":44176,"RHEA_ID":42534,"compounds":"pseudouridine(55) in tRNA => uridine(55) in tRNA"}
{"X":44177,"RHEA_ID":42535,"compounds":"uridine(55) in tRNA <=> pseudouridine(55) in tRNA"}
{"X":44178,"RHEA_ID":45834,"compounds":"3-oxodecanoyl-CoA + H(+) + NADH => (3R)-hydroxydecanoyl-CoA + NAD(+)"}
{"X":44179,"RHEA_ID":42537,"DIRECTION":"LR","MASTER_ID":42536,"ecocyc":"RXN-11840","metacyc":"RXN-11840","compounds":"uridine(65) in tRNA => pseudouridine(65) in tRNA"}
{"X":44180,"RHEA_ID":42538,"compounds":"pseudouridine(65) in tRNA => uridine(65) in tRNA"}
{"X":44181,"RHEA_ID":45837,"compounds":"1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-4-phosphate) + H2O => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}
{"X":44182,"RHEA_ID":45838,"compounds":"1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => 1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-4-phosphate) + H2O"}
{"X":44183,"RHEA_ID":42541,"DIRECTION":"LR","MASTER_ID":42540,"ecocyc":"RXN-11841","metacyc":"RXN-11841","compounds":"uridine(13) in tRNA => pseudouridine(13) in tRNA"}
{"X":44184,"RHEA_ID":42542,"compounds":"pseudouridine(13) in tRNA => uridine(13) in tRNA"}
{"X":44185,"RHEA_ID":42543,"compounds":"uridine(13) in tRNA <=> pseudouridine(13) in tRNA"}
{"X":44186,"RHEA_ID":52527,"compounds":"O2 + prostaglandin A1 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy prostaglandin A1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":44187,"RHEA_ID":42545,"DIRECTION":"LR","MASTER_ID":42544,"ecocyc":"RXN-11842","metacyc":"RXN-11842","compounds":"uridine(32) in tRNA => pseudouridine(32) in tRNA"}
{"X":44188,"RHEA_ID":42546,"compounds":"pseudouridine(32) in tRNA => uridine(32) in tRNA"}
{"X":44189,"RHEA_ID":42547,"compounds":"uridine(32) in tRNA <=> pseudouridine(32) in tRNA"}
{"X":44190,"RHEA_ID":42548,"DIRECTION":"UN","MASTER_ID":42548,"ec":"5.4.99.29","compounds":"23S rRNA uridine(746) = 23S rRNA pseudouridine(746)"}
{"X":44191,"RHEA_ID":52532,"compounds":"adenosine + GTP = AMP + GDP + H(+)"}
{"X":44192,"RHEA_ID":42550,"compounds":"23S rRNA pseudouridine(746) => 23S rRNA uridine(746)"}
{"X":44193,"RHEA_ID":42551,"compounds":"23S rRNA uridine(746) <=> 23S rRNA pseudouridine(746)"}
{"X":44194,"RHEA_ID":52535,"compounds":"adenosine + GTP <=> AMP + GDP + H(+)"}
{"X":44195,"RHEA_ID":52536,"compounds":"adenosine + dGTP = AMP + dGDP + H(+)"}
{"X":44196,"RHEA_ID":42554,"compounds":"pseudouridine(31) in tRNA => uridine(31) in tRNA"}
{"X":44197,"RHEA_ID":42555,"DIRECTION":"BI","MASTER_ID":42552,"metacyc":"RXN-12499","compounds":"uridine(31) in tRNA <=> pseudouridine(31) in tRNA"}
{"X":44198,"RHEA_ID":52539,"compounds":"adenosine + dGTP <=> AMP + dGDP + H(+)"}
{"X":44199,"RHEA_ID":52540,"compounds":"cytidine + phosphate = alpha-D-ribose 1-phosphate + cytosine"}
{"X":44200,"RHEA_ID":42558,"compounds":"pseudouridine(2819) in 21S rRNA => uridine(2819) in 21S rRNA"}
{"X":44201,"RHEA_ID":42559,"DIRECTION":"BI","MASTER_ID":42556,"metacyc":"RXN-12498","compounds":"uridine(2819) in 21S rRNA <=> pseudouridine(2819) in 21S rRNA"}
{"X":44202,"RHEA_ID":52543,"compounds":"cytidine + phosphate <=> alpha-D-ribose 1-phosphate + cytosine"}
{"X":44203,"RHEA_ID":52544,"DIRECTION":"UN","MASTER_ID":52544,"ec":"1.1.1.410","compounds":"D-erythronate + NAD(+) = 2-dehydro-D-erythronate + H(+) + NADH"}
{"X":44204,"RHEA_ID":42562,"compounds":"pseudouridine(27/28) in mitochondrial tRNA => uridine(27/28) in mitochondrial tRNA"}
{"X":44205,"RHEA_ID":42563,"DIRECTION":"BI","MASTER_ID":42560,"metacyc":"RXN-12497","compounds":"uridine(27/28) in mitochondrial tRNA <=> pseudouridine(27/28) in mitochondrial tRNA"}
{"X":44206,"RHEA_ID":52547,"compounds":"D-erythronate + NAD(+) <=> 2-dehydro-D-erythronate + H(+) + NADH"}
{"X":44207,"RHEA_ID":42565,"compounds":"uridine(38/39) in tRNA => pseudouridine(38/39) in tRNA"}
{"X":44208,"RHEA_ID":42566,"compounds":"pseudouridine(38/39) in tRNA => uridine(38/39) in tRNA"}
{"X":44209,"RHEA_ID":42567,"DIRECTION":"BI","MASTER_ID":42564,"metacyc":"RXN-12727","compounds":"uridine(38/39) in tRNA <=> pseudouridine(38/39) in tRNA"}
{"X":44210,"RHEA_ID":52551,"compounds":"L-threonate + NAD(+) <=> 2-dehydro-L-erythronate + H(+) + NADH"}
{"X":44211,"RHEA_ID":42569,"DIRECTION":"LR","MASTER_ID":42568,"metacyc":"RXN-666","compounds":"2,3-dihydroxy-p-cumate + O2 => 3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+)"}
{"X":44212,"RHEA_ID":42570,"compounds":"3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+) => 2,3-dihydroxy-p-cumate + O2"}
{"X":44213,"RHEA_ID":45869,"compounds":"9-decenoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(non-8-en-1-yl)-pyran-2-one + 2 CO2 + 3 CoA"}
{"X":44214,"RHEA_ID":55887,"compounds":"[aequorin] + 3 Ca(2+) <=> [aequorin]--dioxetanone"}
{"X":44215,"RHEA_ID":42573,"compounds":"3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+) => 2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + CO2"}
{"X":44216,"RHEA_ID":42574,"compounds":"2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + CO2 => 3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+)"}
{"X":44217,"RHEA_ID":45873,"compounds":"15-hydroxypentadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(14-hydroxytetradecyl)-pyran-2-one + 2 CO2 + 3 CoA"}
{"X":44218,"RHEA_ID":55891,"compounds":"[aequorin]--dioxetanone <=> [excited state blue fluorescent protein] + CO2"}
{"X":44219,"RHEA_ID":52560,"DIRECTION":"UN","MASTER_ID":52560,"ec":"5.3.1.35","compounds":"2-dehydro-D-erythronate = 3-dehydro-D-erythronate"}
{"X":44220,"RHEA_ID":42578,"compounds":"2-methylpropanoate + 2-oxopent-4-enoate + H(+) => 2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + H2O"}
{"X":44221,"RHEA_ID":52562,"compounds":"3-dehydro-D-erythronate => 2-dehydro-D-erythronate"}
{"X":44222,"RHEA_ID":52564,"DIRECTION":"UN","MASTER_ID":52564,"ec":"5.3.1.35","compounds":"2-dehydro-L-erythronate = 3-dehydro-L-erythronate"}
{"X":44223,"RHEA_ID":42582,"compounds":"AMP + diphosphate + H(+) + L-seryl-tRNA(Sec) => ATP + L-serine + tRNA(Sec)"}
{"X":44224,"RHEA_ID":52566,"compounds":"3-dehydro-L-erythronate => 2-dehydro-L-erythronate"}
{"X":44225,"RHEA_ID":59255,"DIRECTION":"BI","MASTER_ID":59252,"metacyc":"RXN-19895","compounds":"(E)-3-(indol-3-yl)acryloyl-CoA + (R)-3-(indol-3-yl)lactate <=> (E)-3-(indol-3-yl)acrylate + (R)-3-(indol-3-yl)lactoyl-CoA"}
{"X":44226,"RHEA_ID":52568,"compounds":"epitestosterone + UDP-alpha-D-glucuronate = epitestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":44227,"RHEA_ID":42586,"compounds":"1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => 1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O"}
{"X":44228,"RHEA_ID":42587,"compounds":"1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O <=> 1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}
{"X":44229,"RHEA_ID":55903,"compounds":"chloride + FADH2 + L-tryptophan + O2 <=> 6-chloro-L-tryptophan + FAD + 2 H2O"}
{"X":44230,"RHEA_ID":52572,"compounds":"butanoyl-CoA + NAD(+) = (2E)-butenoyl-CoA + H(+) + NADH"}
{"X":44231,"RHEA_ID":42590,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate"}
{"X":44232,"RHEA_ID":45889,"compounds":"12-methyltridecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(11-methyldodecyl)-pyran-2-one + 2 CO2 + 3 CoA"}
{"X":44233,"RHEA_ID":49192,"compounds":"calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 1alpha,23S,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]"}
{"X":44234,"RHEA_ID":42593,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":44235,"RHEA_ID":42594,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA"}
{"X":44236,"RHEA_ID":42595,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":44237,"RHEA_ID":52580,"compounds":"ATP + H2O + Pb(2+)(in) = ADP + H(+) + Pb(2+)(out) + phosphate"}
{"X":44238,"RHEA_ID":42597,"DIRECTION":"LR","MASTER_ID":42596,"reactome":"R-HSA-140355.1","compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 => prostaglandin G2"}
{"X":44239,"RHEA_ID":42598,"compounds":"prostaglandin G2 => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2"}
{"X":44240,"RHEA_ID":45898,"compounds":"CMP + H(+) + N-(acyl)-sphingoid 1-phosphoethanolamine => CDP-ethanolamine + N-acyl-sphingoid base"}
{"X":44241,"RHEA_ID":42600,"compounds":"AH2 + prostaglandin G2 = A + H2O + prostaglandin H2"}
{"X":44242,"RHEA_ID":42601,"compounds":"AH2 + prostaglandin G2 => A + H2O + prostaglandin H2"}
{"X":44243,"RHEA_ID":42602,"compounds":"A + H2O + prostaglandin H2 => AH2 + prostaglandin G2"}
{"X":44244,"RHEA_ID":52586,"compounds":"7alpha-hydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH => chenodeoxycholoyl-CoA + NAD(+)"}
{"X":44245,"RHEA_ID":52588,"DIRECTION":"UN","MASTER_ID":52588,"ec":"1.1.1.395","compounds":"choloyl-CoA + NAD(+) = 7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH"}
{"X":44246,"RHEA_ID":42605,"compounds":"2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+)"}
{"X":44247,"RHEA_ID":42606,"compounds":"(9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+) => 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O"}
{"X":44248,"RHEA_ID":52591,"compounds":"choloyl-CoA + NAD(+) <=> 7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH"}
{"X":44249,"RHEA_ID":52592,"DIRECTION":"UN","MASTER_ID":52592,"ec":"1.1.1.395","compounds":"deoxycholoyl-CoA + NAD(+) = 12alpha-hydroxy-3-oxocholan-24-oyl-CoA + H(+) + NADH"}
{"X":44250,"RHEA_ID":42609,"compounds":"a plastoquinone + (n+1) H(+)(in) + NADH => a plastoquinol + n H(+)(out) + NAD(+)"}
{"X":44251,"RHEA_ID":42610,"compounds":"a plastoquinol + n H(+)(out) + NAD(+) => a plastoquinone + (n+1) H(+)(in) + NADH"}
{"X":44252,"RHEA_ID":55939,"compounds":"all-trans-4-hydroxyretinol + NAD(+) <=> all-trans-4-hydroxyretinal + H(+) + NADH"}
{"X":44253,"RHEA_ID":52596,"DIRECTION":"UN","MASTER_ID":52596,"ec":"1.1.1.395","compounds":"lithocholoyl-CoA + NAD(+) = 3-oxocholan-24-oyl-CoA + H(+) + NADH"}
{"X":44254,"RHEA_ID":42613,"compounds":"a plastoquinone + (n+1) H(+)(in) + NADPH => a plastoquinol + n H(+)(out) + NADP(+)"}
{"X":44255,"RHEA_ID":42614,"compounds":"a plastoquinol + n H(+)(out) + NADP(+) => a plastoquinone + (n+1) H(+)(in) + NADPH"}
{"X":44256,"RHEA_ID":45914,"compounds":"a 4,5-saturated-(3E)-enoyl-CoA + NADP(+) => a (2E,4E)-dienoyl-CoA + H(+) + NADPH"}
{"X":44257,"RHEA_ID":42616,"DIRECTION":"UN","MASTER_ID":42616,"ec":"3.5.1.110","compounds":"(Z)-3-ureidoacrylate peracid + H(+) + H2O = (Z)-3-aminoperacrylic acid + CO2 + NH4(+)"}
{"X":44258,"RHEA_ID":52601,"compounds":"L-methionine + propanoyl-CoA => CoA + H(+) + N-propanoyl-L-methioninate"}
{"X":44259,"RHEA_ID":52602,"compounds":"CoA + H(+) + N-propanoyl-L-methioninate => L-methionine + propanoyl-CoA"}
{"X":44260,"RHEA_ID":42620,"DIRECTION":"UN","MASTER_ID":42620,"ec":"3.5.1.110","compounds":"(Z)-2-methylureidoacrylate + H(+) + H2O = (Z)-2-methylaminoacrylate + CO2 + NH4(+)"}
{"X":44261,"RHEA_ID":42621,"DIRECTION":"LR","MASTER_ID":42620,"ecocyc":"RXN-12895","metacyc":"RXN-12895","compounds":"(Z)-2-methylureidoacrylate + H(+) + H2O => (Z)-2-methylaminoacrylate + CO2 + NH4(+)"}
{"X":44262,"RHEA_ID":45921,"compounds":"16-hydroxyhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(17-hydroxy-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA"}
{"X":44263,"RHEA_ID":55951,"compounds":"A + D-alanine + H2O <=> AH2 + NH4(+) + pyruvate"}
{"X":44264,"RHEA_ID":42624,"DIRECTION":"UN","MASTER_ID":42624,"ec":"3.5.1.110","compounds":"(Z)-3-ureidoacrylate + H(+) + H2O = (Z)-3-aminoacrylate + CO2 + NH4(+)"}
{"X":44265,"RHEA_ID":42625,"DIRECTION":"LR","MASTER_ID":42624,"ecocyc":"RXN-12894","metacyc":"RXN-12894","compounds":"(Z)-3-ureidoacrylate + H(+) + H2O => (Z)-3-aminoacrylate + CO2 + NH4(+)"}
{"X":44266,"RHEA_ID":52610,"compounds":"2-oxobutanoate + H(+) + NADPH => 2-hydroxybutanoate + NADP(+)"}
{"X":44267,"RHEA_ID":55955,"compounds":"GDP-alpha-D-mannose + inositol phosphoceramide <=> a mannosylinositol-1-phospho-N-acyl-sphingoid base + GDP + H(+)"}
{"X":44268,"RHEA_ID":42628,"DIRECTION":"UN","MASTER_ID":42628,"ec":"2.1.1.189","compounds":"S-adenosyl-L-methionine + uridine(747) in 23S rRNA = 5-methyluridine(747) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":44269,"RHEA_ID":42629,"DIRECTION":"LR","MASTER_ID":42628,"ecocyc":"RXN-11600","metacyc":"RXN-11600","compounds":"S-adenosyl-L-methionine + uridine(747) in 23S rRNA => 5-methyluridine(747) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":44270,"RHEA_ID":42630,"compounds":"5-methyluridine(747) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(747) in 23S rRNA"}
{"X":44271,"RHEA_ID":52615,"compounds":"3-(methylsulfanyl)propanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> 3-(methylsulfanyl)acryloyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":44272,"RHEA_ID":52616,"DIRECTION":"UN","MASTER_ID":52616,"ec":"2.7.1.183","compounds":"3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + ATP = 3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-6-O-phospho-alpha-D-mannosyl)-L-threonyl-[protein] + ADP + H(+)"}
{"X":44273,"RHEA_ID":42633,"DIRECTION":"LR","MASTER_ID":42632,"metacyc":"RXN-12465","compounds":"adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine => 5'-deoxyadenosine + 8-methyladenosine(2503) in 23S rRNA + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine"}
{"X":44274,"RHEA_ID":52618,"compounds":"3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-6-O-phospho-alpha-D-mannosyl)-L-threonyl-[protein] + ADP + H(+) => 3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + ATP"}
{"X":44275,"RHEA_ID":55963,"compounds":"4-(trimethylamino)butanoate + ATP + CoA <=> AMP + diphosphate + gamma-butyrobetainyl-CoA"}
{"X":44276,"RHEA_ID":52620,"compounds":"3-methylbutanoyl-CoA = 2,2-dimethylpropanoyl-CoA"}
{"X":44277,"RHEA_ID":42637,"DIRECTION":"LR","MASTER_ID":42636,"metacyc":"RXN-8351","compounds":"AH2 + L-cysteine + Mo-molybdopterin => A + H2O + L-alanine + thio-Mo-molybdopterin"}
{"X":44278,"RHEA_ID":52622,"compounds":"2,2-dimethylpropanoyl-CoA => 3-methylbutanoyl-CoA"}
{"X":44279,"RHEA_ID":55967,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + GTP <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + GDP + H(+)"}
{"X":44280,"RHEA_ID":52624,"compounds":"[amino group carrier protein]-C-terminal-L-glutamate + ATP + L-glutamate = [amino group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ADP + H(+) + phosphate"}
{"X":44281,"RHEA_ID":42641,"DIRECTION":"LR","MASTER_ID":42640,"metacyc":"RXN-11046","compounds":"a 2-demethylmenaquinol + S-adenosyl-L-methionine => a menaquinol + H(+) + S-adenosyl-L-homocysteine"}
{"X":44282,"RHEA_ID":45941,"compounds":"12-methyloctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(13-methyl-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA"}
{"X":44283,"RHEA_ID":55971,"compounds":"(+)-kolavelool + S-adenosyl-L-methionine <=> (+)-O-methylkolavelool + H(+) + S-adenosyl-L-homocysteine"}
{"X":44284,"RHEA_ID":52628,"compounds":"an N-fatty-acyl-L-alpha-amino acid + H2O = a fatty acid + an L-alpha-amino acid"}
{"X":44285,"RHEA_ID":42645,"DIRECTION":"LR","MASTER_ID":42644,"metacyc":"RXN-9101","compounds":"2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[malonate decarboxylase ACP] => diphosphate + holo-[malonate decarboxylase ACP]"}
{"X":44286,"RHEA_ID":52630,"compounds":"a fatty acid + an L-alpha-amino acid => an N-fatty-acyl-L-alpha-amino acid + H2O"}
{"X":44287,"RHEA_ID":52631,"compounds":"an N-fatty-acyl-L-alpha-amino acid + H2O <=> a fatty acid + an L-alpha-amino acid"}
{"X":44288,"RHEA_ID":52632,"compounds":"[amino group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ATP = [amino group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + ADP"}
{"X":44289,"RHEA_ID":42649,"compounds":"(2,5-ethylene furandicarboxylate)(n) + 2 H2O => (2,5-ethylene furandicarboxylate)(n-1) + 2,5-dicarboxyfuran + ethylene glycol + 2 H(+)"}
{"X":44290,"RHEA_ID":52634,"compounds":"[amino group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + ADP => [amino group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ATP"}
{"X":44291,"RHEA_ID":45950,"compounds":"CoA + H(+) + N(6)-acetyl-L-lysyl-[protein] => acetyl-CoA + L-lysyl-[protein]"}
{"X":44292,"RHEA_ID":52636,"DIRECTION":"UN","MASTER_ID":52636,"ec":"1.14.11.n2","compounds":"2-oxoglutarate + a 5-methyl-2'-deoxycytidine in DNA + O2 = a 5-hydroxymethyl-2'-deoxycytidine in DNA + CO2 + succinate"}
{"X":44293,"RHEA_ID":42653,"DIRECTION":"LR","MASTER_ID":42652,"metacyc":"RXN-15775","compounds":"2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine => diphthine methyl ester-[translation elongation factor 2] + 3 H(+) + 4 S-adenosyl-L-homocysteine"}
{"X":44294,"RHEA_ID":52638,"compounds":"a 5-hydroxymethyl-2'-deoxycytidine in DNA + CO2 + succinate => 2-oxoglutarate + a 5-methyl-2'-deoxycytidine in DNA + O2"}
{"X":44295,"RHEA_ID":42655,"compounds":"2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine <=> diphthine methyl ester-[translation elongation factor 2] + 3 H(+) + 4 S-adenosyl-L-homocysteine"}
{"X":44296,"RHEA_ID":52640,"compounds":"(2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + octanoyl-CoA = (2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + CoA"}
{"X":44297,"RHEA_ID":42657,"DIRECTION":"LR","MASTER_ID":42656,"metacyc":"RXN-15776","compounds":"diphthine methyl ester-[translation elongation factor 2] + H2O => diphthine-[translation elongation factor 2] + H(+) + methanol"}
{"X":44298,"RHEA_ID":52642,"compounds":"(2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + CoA => (2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + octanoyl-CoA"}
{"X":44299,"RHEA_ID":52643,"compounds":"(2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + octanoyl-CoA <=> (2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + CoA"}
{"X":44300,"RHEA_ID":52644,"DIRECTION":"UN","MASTER_ID":52644,"ec":"3.1.1.25","compounds":"D-xylono-1,4-lactone 5-phosphate + H2O = 5-phospho-D-xylonate + H(+)"}
{"X":44301,"RHEA_ID":42661,"compounds":"NAD(+) + UDP-N-acetyl-alpha-D-glucosamine => H(+) + NADH + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose"}
{"X":44302,"RHEA_ID":52645,"DIRECTION":"LR","MASTER_ID":52644,"metacyc":"RXN-19752","compounds":"D-xylono-1,4-lactone 5-phosphate + H2O => 5-phospho-D-xylonate + H(+)"}
{"X":44303,"RHEA_ID":45962,"compounds":"4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 24,25-dihydrolanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]"}
{"X":44304,"RHEA_ID":42664,"DIRECTION":"UN","MASTER_ID":42664,"ec":"1.1.1.376","compounds":"L-arabinofuranose + NADP(+) = H(+) + L-arabinono-1,4-lactone + NADPH"}
{"X":44305,"RHEA_ID":42665,"DIRECTION":"LR","MASTER_ID":42664,"metacyc":"RXN-8774","compounds":"L-arabinofuranose + NADP(+) => H(+) + L-arabinono-1,4-lactone + NADPH"}
{"X":44306,"RHEA_ID":52648,"DIRECTION":"UN","MASTER_ID":52648,"ec":"3.1.1.104","compounds":"H2O + L-arabino-1,4-lactone 5-phosphate = 5-phospho-L-arabinonate + H(+)"}
{"X":44307,"RHEA_ID":45966,"compounds":"2 AMP + ATP + 2 H(+) => 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 H2O"}
{"X":44308,"RHEA_ID":52650,"compounds":"5-phospho-L-arabinonate + H(+) => H2O + L-arabino-1,4-lactone 5-phosphate"}
{"X":44309,"RHEA_ID":42668,"DIRECTION":"UN","MASTER_ID":42668,"ec":"1.1.1.378","compounds":"L-rhamnofuranose + NADP(+) = H(+) + L-rhamnono-1,4-lactone + NADPH"}
{"X":44310,"RHEA_ID":42669,"DIRECTION":"LR","MASTER_ID":42668,"metacyc":"RXN-12158","compounds":"L-rhamnofuranose + NADP(+) => H(+) + L-rhamnono-1,4-lactone + NADPH"}
{"X":44311,"RHEA_ID":52653,"compounds":"lanosterol + S-adenosyl-L-methionine => 24-methylene-24-dihydrolanosterol + H(+) + S-adenosyl-L-homocysteine"}
{"X":44312,"RHEA_ID":45971,"compounds":"androst-4-ene-3,17-dione + H(+) + NADH + O2 <=> 9alpha-hydroxy-androst-4-ene-3,17-dione + H2O + NAD(+)"}
{"X":44313,"RHEA_ID":42672,"DIRECTION":"UN","MASTER_ID":42672,"ec":"1.14.99.50","compounds":"hercynine + L-gamma-glutamyl-L-cysteine + O2 = H2O + L-gamma-glutamyl-hercynylcysteine S-oxide"}
{"X":44314,"RHEA_ID":42673,"DIRECTION":"LR","MASTER_ID":42672,"metacyc":"RXN-14430","compounds":"hercynine + L-gamma-glutamyl-L-cysteine + O2 => H2O + L-gamma-glutamyl-hercynylcysteine S-oxide"}
{"X":44315,"RHEA_ID":45974,"compounds":"9alpha-hydroxy-3-oxochol-4-en-22-oate + H2O + NAD(+) => 3-oxochol-4-en-22-oate + H(+) + NADH + O2"}
{"X":44316,"RHEA_ID":52658,"compounds":"a long-chain 3-oxo-fatty acyl-CoA + H(+) + NADH => a long-chain (3S)-hydroxy fatty acyl-CoA + NAD(+)"}
{"X":44317,"RHEA_ID":42676,"DIRECTION":"UN","MASTER_ID":42676,"ec":"1.14.99.52","compounds":"L-cysteine + L-histidine + O2 = H2O + L-alanin-3-yl L-histidin-5-yl sulfoxide"}
{"X":44318,"RHEA_ID":42677,"DIRECTION":"LR","MASTER_ID":42676,"metacyc":"RXN-15802","compounds":"L-cysteine + L-histidine + O2 => H2O + L-alanin-3-yl L-histidin-5-yl sulfoxide"}
{"X":44319,"RHEA_ID":52661,"compounds":"an L-alpha-amino acid + ATP + holo-[ACP] => AMP + an L-alpha-aminoacyl-[ACP] + diphosphate"}
{"X":44320,"RHEA_ID":45979,"compounds":"3-oxochola-1,4-dien-22-oate + H(+) + NADH + O2 <=> 9alpha-hydroxy-3-oxochola-1,4-dien-22-oate + H2O + NAD(+)"}
{"X":44321,"RHEA_ID":42680,"compounds":"2 hercynine + 2 L-selenocysteine + O2 = 2 H2O + 2 hercynylselenocysteine"}
{"X":44322,"RHEA_ID":42681,"compounds":"2 hercynine + 2 L-selenocysteine + O2 => 2 H2O + 2 hercynylselenocysteine"}
{"X":44323,"RHEA_ID":45982,"compounds":"9alpha-hydroxy-3-oxochol-4-en-22-oyl-CoA + H2O + NAD(+) => 3-oxochol-4-en-22-oyl-CoA + H(+) + NADH + O2"}
{"X":44324,"RHEA_ID":52666,"compounds":"a short-chain (2E)-enoyl-CoA + H2O => a short-chain (3S)-hydroxyacyl-CoA"}
{"X":44325,"RHEA_ID":42684,"DIRECTION":"UN","MASTER_ID":42684,"ec":"3.5.1.118","compounds":"H2O + L-gamma-glutamyl-hercynylcysteine S-oxide = L-glutamate + S-(hercyn-2-yl)-L-cysteine S-oxide"}
{"X":44326,"RHEA_ID":42685,"DIRECTION":"LR","MASTER_ID":42684,"metacyc":"RXN-14429","compounds":"H2O + L-gamma-glutamyl-hercynylcysteine S-oxide => L-glutamate + S-(hercyn-2-yl)-L-cysteine S-oxide"}
{"X":44327,"RHEA_ID":52669,"compounds":"[amino group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + NADP(+) + phosphate => [amino group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + H(+) + NADPH"}
{"X":44328,"RHEA_ID":56016,"compounds":"H2O + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2) = beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2)"}
{"X":44329,"RHEA_ID":42688,"DIRECTION":"UN","MASTER_ID":42688,"ec":"4.4.1.36","compounds":"AH2 + H(+) + S-(hercyn-2-yl)-L-cysteine S-oxide = A + ergothioneine + NH4(+) + pyruvate"}
{"X":44330,"RHEA_ID":42689,"DIRECTION":"LR","MASTER_ID":42688,"metacyc":"RXN-14428","compounds":"AH2 + H(+) + S-(hercyn-2-yl)-L-cysteine S-oxide => A + ergothioneine + NH4(+) + pyruvate"}
{"X":44331,"RHEA_ID":52673,"compounds":"2-oxoglutarate + [amino group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate => [amino group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + L-glutamate"}
{"X":44332,"RHEA_ID":52674,"compounds":"[amino group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + L-glutamate => 2-oxoglutarate + [amino group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate"}
{"X":44333,"RHEA_ID":42692,"DIRECTION":"UN","MASTER_ID":42692,"ec":"2.4.99.16","compounds":"[(1->4)-alpha-D-glucosyl](n) + alpha-maltose 1-phosphate = [(1->4)-alpha-D-glucosyl](n+2) + phosphate"}
{"X":44334,"RHEA_ID":42693,"compounds":"[(1->4)-alpha-D-glucosyl](n) + alpha-maltose 1-phosphate => [(1->4)-alpha-D-glucosyl](n+2) + phosphate"}
{"X":44335,"RHEA_ID":52677,"DIRECTION":"LR","MASTER_ID":52676,"metacyc":"RXN-15004","compounds":"[amino group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + H2O => [amino group carrier protein]-C-terminal-L-glutamate + L-ornithine"}
{"X":44336,"RHEA_ID":52678,"compounds":"[amino group carrier protein]-C-terminal-L-glutamate + L-ornithine => [amino group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + H2O"}
{"X":44337,"RHEA_ID":42696,"compounds":"H2O + hercynylselenocysteine = NH4(+) + pyruvate + selnoneine thione"}
{"X":44338,"RHEA_ID":42697,"compounds":"H2O + hercynylselenocysteine => NH4(+) + pyruvate + selnoneine thione"}
{"X":44339,"RHEA_ID":52681,"compounds":"acetyl-CoA + L-alpha-phenylglycine => CoA + H(+) + N-acetyl-L-alpha-phenylglycine"}
{"X":44340,"RHEA_ID":52682,"compounds":"CoA + H(+) + N-acetyl-L-alpha-phenylglycine => acetyl-CoA + L-alpha-phenylglycine"}
{"X":44341,"RHEA_ID":42700,"DIRECTION":"UN","MASTER_ID":42700,"ec":"3.1.1.85","compounds":"6-carboxyhexanoyl-[ACP] methyl ester + H2O = 6-carboxyhexanoyl-[ACP] + H(+) + methanol"}
{"X":44342,"RHEA_ID":52684,"compounds":"NAD(+) + pyridoxine = H(+) + NADH + pyridoxal"}
{"X":44343,"RHEA_ID":52685,"compounds":"NAD(+) + pyridoxine => H(+) + NADH + pyridoxal"}
{"X":44344,"RHEA_ID":42704,"DIRECTION":"UN","MASTER_ID":42704,"ec":"1.14.99.51","compounds":"hercynine + L-cysteine + O2 = H2O + S-(hercyn-2-yl)-L-cysteine S-oxide"}
{"X":44345,"RHEA_ID":52688,"compounds":"3-phenyllactate + NAD(+) = 3-phenylpyruvate + H(+) + NADH"}
{"X":44346,"RHEA_ID":42706,"compounds":"H2O + S-(hercyn-2-yl)-L-cysteine S-oxide => hercynine + L-cysteine + O2"}
{"X":44347,"RHEA_ID":42707,"compounds":"hercynine + L-cysteine + O2 <=> H2O + S-(hercyn-2-yl)-L-cysteine S-oxide"}
{"X":44348,"RHEA_ID":42708,"DIRECTION":"UN","MASTER_ID":42708,"ec":"2.1.1.33","compounds":"guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine"}
{"X":44349,"RHEA_ID":42709,"DIRECTION":"LR","MASTER_ID":42708,"ecocyc":"TRNA-GUANINE-N7--METHYLTRANSFERASE-RXN","metacyc":"TRNA-GUANINE-N7--METHYLTRANSFERASE-RXN","compounds":"guanosine(46) in tRNA + S-adenosyl-L-methionine => N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine"}
{"X":44350,"RHEA_ID":42710,"compounds":"N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine => guanosine(46) in tRNA + S-adenosyl-L-methionine"}
{"X":44351,"RHEA_ID":46011,"compounds":"CoA + NAD(+) + pentanal <=> H(+) + NADH + pentanoyl-CoA"}
{"X":44352,"RHEA_ID":42712,"DIRECTION":"UN","MASTER_ID":42712,"ec":"2.1.1.35","compounds":"S-adenosyl-L-methionine + uridine(54) in tRNA = 5-methyluridine(54) in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":44353,"RHEA_ID":52696,"compounds":"a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-galactose = a 1,2-diacyl-3-O-[alpha-D-galactopyranosyl-(1->2)-alpha-D-glucopyranosyl]-sn-glycerol + H(+) + UDP"}
{"X":44354,"RHEA_ID":42714,"compounds":"5-methyluridine(54) in tRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(54) in tRNA"}
{"X":44355,"RHEA_ID":52698,"compounds":"a 1,2-diacyl-3-O-[alpha-D-galactopyranosyl-(1->2)-alpha-D-glucopyranosyl]-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-galactose"}
{"X":44356,"RHEA_ID":42716,"compounds":"(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + H2O + selenophosphate = 5-methylaminomethyl-2-selenouridine(34) in tRNA + diphosphate + phosphate + thiogeraniol"}
{"X":44357,"RHEA_ID":52704,"compounds":"H2O + UMP = D-ribose 5-phosphate + uracil"}
{"X":44358,"RHEA_ID":52705,"compounds":"H2O + UMP => D-ribose 5-phosphate + uracil"}
{"X":44359,"RHEA_ID":52706,"compounds":"D-ribose 5-phosphate + uracil => H2O + UMP"}
{"X":44360,"RHEA_ID":42720,"DIRECTION":"UN","MASTER_ID":42720,"ec":"2.1.1.166","compounds":"S-adenosyl-L-methionine + uridine(2552) in 23S rRNA = 2'-O-methyluridine(2552) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":44361,"RHEA_ID":52708,"compounds":"GMP + H2O = D-ribose 5-phosphate + guanine"}
{"X":44362,"RHEA_ID":52709,"compounds":"GMP + H2O => D-ribose 5-phosphate + guanine"}
{"X":44363,"RHEA_ID":52710,"compounds":"D-ribose 5-phosphate + guanine => GMP + H2O"}
{"X":44364,"RHEA_ID":42724,"DIRECTION":"UN","MASTER_ID":42724,"ec":"2.1.1.167","compounds":"guanosine(2922) in 27S pre-rRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(2922) in 27S pre-rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":44365,"RHEA_ID":52712,"compounds":"dTMP + H2O = 2-deoxy-D-ribose 5-phosphate + thymine"}
{"X":44366,"RHEA_ID":42726,"compounds":"2'-O-methylguanosine(2922) in 27S pre-rRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(2922) in 27S pre-rRNA + S-adenosyl-L-methionine"}
{"X":44367,"RHEA_ID":52714,"compounds":"2-deoxy-D-ribose 5-phosphate + thymine => dTMP + H2O"}
{"X":44368,"RHEA_ID":42728,"DIRECTION":"UN","MASTER_ID":42728,"ec":"2.1.1.168","compounds":"S-adenosyl-L-methionine + uridine(2791) in 21S rRNA = 2'-O-methyluridine(2791) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":44369,"RHEA_ID":42729,"DIRECTION":"LR","MASTER_ID":42728,"metacyc":"RXN-11580","compounds":"S-adenosyl-L-methionine + uridine(2791) in 21S rRNA => 2'-O-methyluridine(2791) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":44370,"RHEA_ID":42730,"compounds":"2'-O-methyluridine(2791) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(2791) in 21S rRNA"}
{"X":44371,"RHEA_ID":52718,"compounds":"a long-chain primary fatty alcohol + CoA + 2 NADP(+) => a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH"}
{"X":44372,"RHEA_ID":42732,"DIRECTION":"UN","MASTER_ID":42732,"ec":"2.1.1.170","compounds":"guanosine(527) in 16S rRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(527) in 16S rRNA + S-adenosyl-L-homocysteine"}
{"X":44373,"RHEA_ID":52720,"DIRECTION":"UN","MASTER_ID":52720,"ec":"2.8.1.15","compounds":"5-methyluridine(54) in tRNA + [TtuB sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + ATP + H2O = 5-methyl-2-thiouridine(54) in tRNA + [TtuB sulfur-carrier protein]-C-terminal Gly-Gly + AMP + diphosphate + 2 H(+)"}
{"X":44374,"RHEA_ID":42734,"compounds":"N(7)-methylguanosine(527) in 16S rRNA + S-adenosyl-L-homocysteine => guanosine(527) in 16S rRNA + S-adenosyl-L-methionine"}
{"X":44375,"RHEA_ID":52722,"compounds":"5-methyl-2-thiouridine(54) in tRNA + [TtuB sulfur-carrier protein]-C-terminal Gly-Gly + AMP + diphosphate + 2 H(+) => 5-methyluridine(54) in tRNA + [TtuB sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + ATP + H2O"}
{"X":44376,"RHEA_ID":42736,"DIRECTION":"UN","MASTER_ID":42736,"ec":"2.1.1.172","compounds":"guanosine(1207) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine"}
{"X":44377,"RHEA_ID":42737,"DIRECTION":"LR","MASTER_ID":42736,"ecocyc":"RXN-11576","metacyc":"RXN-11576","compounds":"guanosine(1207) in 16S rRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine"}
{"X":44378,"RHEA_ID":42738,"compounds":"H(+) + N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine => guanosine(1207) in 16S rRNA + S-adenosyl-L-methionine"}
{"X":44379,"RHEA_ID":52726,"compounds":"adenosine 3',5'-bisphosphate + an omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + H(+) => 3'-phosphoadenylyl sulfate + an aliphatic desulfo-glucosinolate"}
{"X":44380,"RHEA_ID":42740,"DIRECTION":"UN","MASTER_ID":42740,"ec":"2.1.1.173","compounds":"guanosine(2445) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine"}
{"X":44381,"RHEA_ID":42741,"DIRECTION":"LR","MASTER_ID":42740,"ecocyc":"RXN-11574","metacyc":"RXN-11574","compounds":"guanosine(2445) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine"}
{"X":44382,"RHEA_ID":52729,"DIRECTION":"LR","MASTER_ID":52728,"metacyc":"RXN-10451","compounds":"3'-phosphoadenylyl sulfate + a 12-hydroxyjasmonate => a 12-sulfojasmonate + adenosine 3',5'-bisphosphate + H(+)"}
{"X":44383,"RHEA_ID":46042,"compounds":"ADP + dCMP + H(+) => 2'-deoxycytidine + ATP"}
{"X":44384,"RHEA_ID":42744,"DIRECTION":"UN","MASTER_ID":42744,"ec":"2.1.1.174","compounds":"guanosine(1835) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine"}
{"X":44385,"RHEA_ID":42745,"DIRECTION":"LR","MASTER_ID":42744,"ecocyc":"RXN-11635","metacyc":"RXN-11635","compounds":"guanosine(1835) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine"}
{"X":44386,"RHEA_ID":42746,"compounds":"H(+) + N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine => guanosine(1835) in 23S rRNA + S-adenosyl-L-methionine"}
{"X":44387,"RHEA_ID":46046,"compounds":"(2E)-octenoyl-CoA => (3Z)-octenoyl-CoA"}
{"X":44388,"RHEA_ID":42748,"DIRECTION":"UN","MASTER_ID":42748,"ec":"2.1.1.176","compounds":"cytidine(967) in 16S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(967) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":44389,"RHEA_ID":42749,"DIRECTION":"LR","MASTER_ID":42748,"ecocyc":"RXN-11591","metacyc":"RXN-11591","compounds":"cytidine(967) in 16S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(967) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":44390,"RHEA_ID":52737,"DIRECTION":"LR","MASTER_ID":52736,"metacyc":"RXN-1443","compounds":"3'-phosphoadenylyl sulfate + indolylmethyl-desulfoglucosinolate => adenosine 3',5'-bisphosphate + glucobrassicin + H(+)"}
{"X":44391,"RHEA_ID":52738,"compounds":"adenosine 3',5'-bisphosphate + glucobrassicin + H(+) => 3'-phosphoadenylyl sulfate + indolylmethyl-desulfoglucosinolate"}
{"X":44392,"RHEA_ID":42752,"DIRECTION":"UN","MASTER_ID":42752,"ec":"2.1.1.177","compounds":"pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine"}
{"X":44393,"RHEA_ID":42753,"DIRECTION":"LR","MASTER_ID":42752,"ecocyc":"RXN-11592","metacyc":"RXN-11592","compounds":"pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine"}
{"X":44394,"RHEA_ID":52741,"DIRECTION":"LR","MASTER_ID":52740,"metacyc":"RXN-17951","compounds":"glyphosate + H2O + O2 => aminomethylphosphonate + glyoxylate + H(+) + H2O2"}
{"X":44395,"RHEA_ID":52742,"compounds":"aminomethylphosphonate + glyoxylate + H(+) + H2O2 => glyphosate + H2O + O2"}
{"X":44396,"RHEA_ID":42756,"DIRECTION":"UN","MASTER_ID":42756,"ec":"2.1.1.178","compounds":"cytidine(1407) in 16S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(1407) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":44397,"RHEA_ID":42757,"DIRECTION":"LR","MASTER_ID":42756,"ecocyc":"RXN-11593","metacyc":"RXN-11593","compounds":"cytidine(1407) in 16S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(1407) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":44398,"RHEA_ID":52745,"DIRECTION":"LR","MASTER_ID":52744,"metacyc":"RXN-18149","compounds":"cyclobis-(1->3)-alpha-isomaltosyl + H2O => alpha-isomaltosyl-(1->3)-isomaltose"}
{"X":44399,"RHEA_ID":52746,"compounds":"alpha-isomaltosyl-(1->3)-isomaltose => cyclobis-(1->3)-alpha-isomaltosyl + H2O"}
{"X":44400,"RHEA_ID":42760,"DIRECTION":"UN","MASTER_ID":42760,"ec":"1.2.1.90","compounds":"D-glyceraldehyde 3-phosphate + H2O + NAD(+) = (2R)-3-phosphoglycerate + 2 H(+) + NADH"}
{"X":44401,"RHEA_ID":42761,"DIRECTION":"LR","MASTER_ID":42760,"metacyc":"RXN-3443","compounds":"D-glyceraldehyde 3-phosphate + H2O + NAD(+) => (2R)-3-phosphoglycerate + 2 H(+) + NADH"}
{"X":44402,"RHEA_ID":52749,"DIRECTION":"LR","MASTER_ID":52748,"metacyc":"RXN-18151","compounds":"alpha-isomaltosyl-(1->3)-isomaltose + H2O => 2 isomaltose"}
{"X":44403,"RHEA_ID":52750,"compounds":"2 isomaltose => alpha-isomaltosyl-(1->3)-isomaltose + H2O"}
{"X":44404,"RHEA_ID":46063,"compounds":"(11E)-octadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> (5Z,11E)-octadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":44405,"RHEA_ID":42765,"compounds":"formate + 2 H(+) + oxidized coenzyme F420-(gamma-Glu)(n) => CO2 + reduced coenzyme F420-(gamma-Glu)(n)"}
{"X":44406,"RHEA_ID":52753,"DIRECTION":"LR","MASTER_ID":52752,"metacyc":"RXN-18147","compounds":"H2O + isomaltose => beta-D-glucose + D-glucose"}
{"X":44407,"RHEA_ID":52754,"compounds":"beta-D-glucose + D-glucose => H2O + isomaltose"}
{"X":44408,"RHEA_ID":46067,"compounds":"(11E)-octadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> (6Z,11E)-octadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":44409,"RHEA_ID":42769,"compounds":"a (2S)-2-hydroxycarboxylate + NADP(+) => a 2-oxocarboxylate + H(+) + NADPH"}
{"X":44410,"RHEA_ID":52757,"DIRECTION":"LR","MASTER_ID":52756,"metacyc":"RXN-18176","compounds":"an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O => an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-cysteinylglycine + L-glutamate"}
{"X":44411,"RHEA_ID":42773,"DIRECTION":"LR","MASTER_ID":42772,"metacyc":"RXN-11594","compounds":"guanosine(1405) in 16S rRNA + S-adenosyl-L-methionine => N(7)-methylguanosine(1405) in 16S rRNA + S-adenosyl-L-homocysteine"}
{"X":44412,"RHEA_ID":52761,"DIRECTION":"LR","MASTER_ID":52760,"metacyc":"RXN-11428","compounds":"(Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O => (Z)-1-(glycyl-L-cystein-S-yl)-2-phenylacetohydroximate + L-glutamate"}
{"X":44413,"RHEA_ID":42775,"compounds":"guanosine(1405) in 16S rRNA + S-adenosyl-L-methionine <=> N(7)-methylguanosine(1405) in 16S rRNA + S-adenosyl-L-homocysteine"}
{"X":44414,"RHEA_ID":46075,"compounds":"(2E)-hexadecenoyl-CoA + H(+) + NADH <=> hexadecanoyl-CoA + NAD(+)"}
{"X":44415,"RHEA_ID":42777,"DIRECTION":"LR","MASTER_ID":42776,"metacyc":"RXN-11595","compounds":"adenosine(1408) in 16S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyladenosine(1408) in 16S rRNA + S-adenosyl-L-homocysteine"}
{"X":44416,"RHEA_ID":52765,"DIRECTION":"LR","MASTER_ID":52764,"metacyc":"RXN-11429","compounds":"(E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O => (E)-1-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetohydroximate + L-glutamate"}
{"X":44417,"RHEA_ID":42779,"compounds":"adenosine(1408) in 16S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyladenosine(1408) in 16S rRNA + S-adenosyl-L-homocysteine"}
{"X":44418,"RHEA_ID":46079,"compounds":"(2E)-eicosenoyl-CoA + H(+) + NADH <=> eicosanoyl-CoA + NAD(+)"}
{"X":44419,"RHEA_ID":42781,"DIRECTION":"LR","MASTER_ID":42780,"metacyc":"RXN-11634","compounds":"adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine => 4 H(+) + N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine"}
{"X":44420,"RHEA_ID":52769,"DIRECTION":"LR","MASTER_ID":52768,"metacyc":"RXN-11664","compounds":"2-(glutathion-S-yl)-2-(1H-indol-3-yl)acetonitrile + H2O => 2-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetonitrile + L-glutamate"}
{"X":44421,"RHEA_ID":42783,"compounds":"adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine <=> 4 H(+) + N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine"}
{"X":44422,"RHEA_ID":46083,"compounds":"(2E)-tetracosenoyl-CoA + H(+) + NADH <=> NAD(+) + tetracosanoyl-CoA"}
{"X":44423,"RHEA_ID":42785,"DIRECTION":"LR","MASTER_ID":42784,"metacyc":"RXN-11597","compounds":"adenosine(2085) in 23S rRNA + 2 S-adenosyl-L-methionine => 2 H(+) + N(6)-dimethyladenosine(2085) in 23S rRNA + 2 S-adenosyl-L-homocysteine"}
{"X":44424,"RHEA_ID":52773,"DIRECTION":"LR","MASTER_ID":52772,"metacyc":"RXN-18377","compounds":"7,8-dihydroneopterin 3'-triphosphate => 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde triphosphate"}
{"X":44425,"RHEA_ID":52774,"compounds":"6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde triphosphate => 7,8-dihydroneopterin 3'-triphosphate"}
{"X":44426,"RHEA_ID":42789,"DIRECTION":"LR","MASTER_ID":42788,"ecocyc":"RXN-11589","metacyc":"RXN-11589","compounds":"cytidine(2498) in 23S rRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(2498) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":44427,"RHEA_ID":52777,"DIRECTION":"LR","MASTER_ID":52776,"metacyc":"RXN-18199","compounds":"2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => camalexin + CO2 + 2 H(+) + 4 H2O + hydrogen cyanide + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":44428,"RHEA_ID":42791,"compounds":"cytidine(2498) in 23S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(2498) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":44429,"RHEA_ID":46095,"compounds":"(25R)-cholest-5-ene-3beta,26-diol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta-hydroxy-5-cholesten-26-al + 2 H2O + 2 oxidized [adrenodoxin]"}
{"X":44430,"RHEA_ID":42793,"compounds":"cholesterol + hexadecanoyl-CoA => cholesteryl hexadecanoate + CoA"}
{"X":44431,"RHEA_ID":52781,"DIRECTION":"LR","MASTER_ID":52780,"metacyc":"RXN-18088","compounds":"H2O + S-(hercyn-2-yl)-L-cysteine S-oxide => 2-sulfenohercynine + NH4(+) + pyruvate"}
{"X":44432,"RHEA_ID":42795,"compounds":"cholesterol + hexadecanoyl-CoA <=> cholesteryl hexadecanoate + CoA"}
{"X":44433,"RHEA_ID":46099,"compounds":"3-phenylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4 CO2 + 4 CoA + dihydropinosylvin"}
{"X":44434,"RHEA_ID":42797,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + cholesterol => cholesteryl (9Z,12Z)-octadecadienoate + CoA"}
{"X":44435,"RHEA_ID":52785,"DIRECTION":"LR","MASTER_ID":52784,"metacyc":"RXN-18089","compounds":"2-sulfenohercynine + AH2 + H(+) => A + ergothioneine + H2O"}
{"X":44436,"RHEA_ID":42799,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + cholesterol <=> cholesteryl (9Z,12Z)-octadecadienoate + CoA"}
{"X":44437,"RHEA_ID":46103,"compounds":"11-deoxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> cortisol + H2O + 2 oxidized [adrenodoxin]"}
{"X":44438,"RHEA_ID":42801,"compounds":"15-cis-4,4'-diapophytoene + 3 FAD + 3 H(+) => all-trans-4,4'-diaponeurosporene + 3 FADH2"}
{"X":44439,"RHEA_ID":52789,"DIRECTION":"LR","MASTER_ID":52788,"metacyc":"RXN-8378","compounds":"chlorophyll a + 2 H(+) => Mg(2+) + pheophytin a"}
{"X":44440,"RHEA_ID":52790,"compounds":"Mg(2+) + pheophytin a => chlorophyll a + 2 H(+)"}
{"X":44441,"RHEA_ID":42804,"DIRECTION":"UN","MASTER_ID":42804,"ec":"1.5.99.15","compounds":"5,6,7,8-tetrahydromethanopterin + A = 7,8-dihydromethanopterin + AH2"}
{"X":44442,"RHEA_ID":42805,"compounds":"5,6,7,8-tetrahydromethanopterin + A => 7,8-dihydromethanopterin + AH2"}
{"X":44443,"RHEA_ID":42806,"DIRECTION":"RL","MASTER_ID":42804,"metacyc":"RXN-15555","compounds":"7,8-dihydromethanopterin + AH2 => 5,6,7,8-tetrahydromethanopterin + A"}
{"X":44444,"RHEA_ID":52794,"compounds":"Mg(2+) + pheophorbide a => chlorophyllide a + 2 H(+)"}
{"X":44445,"RHEA_ID":46111,"compounds":"(2E,6E,10E)-geranylgeraniol + H(+) + 2 NADPH + 2 O2 <=> (2E,6E,10E)-geranylgeranate + 3 H2O + 2 NADP(+)"}
{"X":44446,"RHEA_ID":42809,"compounds":"2 H(+) + 3 H2O + hydrogen sulfide + 3 oxidized coenzyme F420-(gamma-Glu)(n) => 3 reduced coenzyme F420-(gamma-Glu)(n) + sulfite"}
{"X":44447,"RHEA_ID":52797,"compounds":"2 H(+) + Ni-sirohydrochlorin => Ni(2+) + sirohydrochlorin"}
{"X":44448,"RHEA_ID":52798,"DIRECTION":"RL","MASTER_ID":52796,"metacyc":"RXN-8059","compounds":"Ni(2+) + sirohydrochlorin => 2 H(+) + Ni-sirohydrochlorin"}
{"X":44449,"RHEA_ID":46115,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine"}
{"X":44450,"RHEA_ID":42813,"compounds":"cholesterol + octadecanoyl-CoA => cholesteryl octadecanoate + CoA"}
{"X":44451,"RHEA_ID":52801,"DIRECTION":"LR","MASTER_ID":52800,"metacyc":"RXN-18314","compounds":"acetoacetyl-CoA + ATP + L-isoleucine => AMP + CoA + diphosphate + 2 H(+) + tenuazonic acid"}
{"X":44452,"RHEA_ID":42815,"compounds":"cholesterol + octadecanoyl-CoA <=> cholesteryl octadecanoate + CoA"}
{"X":44453,"RHEA_ID":42817,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol => cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA"}
{"X":44454,"RHEA_ID":52805,"DIRECTION":"LR","MASTER_ID":52804,"metacyc":"RXN-18791","compounds":"(2E,6E)-farnesyl diphosphate => (+)-eremophilene + diphosphate"}
{"X":44455,"RHEA_ID":42819,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol <=> cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA"}
{"X":44456,"RHEA_ID":46123,"compounds":"4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 4beta,7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":44457,"RHEA_ID":42821,"DIRECTION":"LR","MASTER_ID":42820,"metacyc":"RXN-15434","compounds":"2 H(+) + 2 NADPH + 2 O2 + tetracenomycin A2 => H2O + 2 NADP(+) + tetracenomycin C"}
{"X":44458,"RHEA_ID":42822,"compounds":"H2O + 2 NADP(+) + tetracenomycin C => 2 H(+) + 2 NADPH + 2 O2 + tetracenomycin A2"}
{"X":44459,"RHEA_ID":52810,"compounds":"H(+) + N(6)-methyladenosine in U6 snRNA + S-adenosyl-L-homocysteine => adenosine in U6 snRNA + S-adenosyl-L-methionine"}
{"X":44460,"RHEA_ID":42824,"DIRECTION":"UN","MASTER_ID":42824,"ec":"1.14.13.200","compounds":"2 H(+) + 2 NADH + 2 O2 + tetracenomycin A2 = H2O + 2 NAD(+) + tetracenomycin C"}
{"X":44461,"RHEA_ID":52812,"compounds":"1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O = (9Z,12Z)-octadecadienoate + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H(+)"}
{"X":44462,"RHEA_ID":52813,"compounds":"1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O => (9Z,12Z)-octadecadienoate + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H(+)"}
{"X":44463,"RHEA_ID":52814,"compounds":"(9Z,12Z)-octadecadienoate + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H(+) => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O"}
{"X":44464,"RHEA_ID":42828,"DIRECTION":"UN","MASTER_ID":42828,"ec":"1.14.15.31","compounds":"2-hydroxy-5-methyl-1-naphthoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2,7-dihydroxy-5-methyl-1-naphthoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":44465,"RHEA_ID":52816,"compounds":"an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP"}
{"X":44466,"RHEA_ID":42830,"compounds":"2,7-dihydroxy-5-methyl-1-naphthoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-hydroxy-5-methyl-1-naphthoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":44467,"RHEA_ID":52818,"compounds":"an N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":44468,"RHEA_ID":42832,"DIRECTION":"UN","MASTER_ID":42832,"ec":"2.2.1.12","compounds":"(2E)-octenal + H(+) + pyruvate = (S)-3-acetyloctanal + CO2"}
{"X":44469,"RHEA_ID":52820,"compounds":"L-serine + succinyl-CoA = CoA + O-succinyl-L-serine"}
{"X":44470,"RHEA_ID":42834,"compounds":"(S)-3-acetyloctanal + CO2 => (2E)-octenal + H(+) + pyruvate"}
{"X":44471,"RHEA_ID":52822,"compounds":"CoA + O-succinyl-L-serine => L-serine + succinyl-CoA"}
{"X":44472,"RHEA_ID":42836,"DIRECTION":"UN","MASTER_ID":42836,"ec":"2.3.1.236","compounds":"acetyl-CoA + 7 H(+) + 5 malonyl-CoA + 3 NADPH = 5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 4 H2O + 3 NADP(+)"}
{"X":44473,"RHEA_ID":52824,"compounds":"(1R,4R)-dihydrocarvone + H(+) + NADPH + O2 = (4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)"}
{"X":44474,"RHEA_ID":52825,"DIRECTION":"LR","MASTER_ID":52824,"metacyc":"RXN-9391","compounds":"(1R,4R)-dihydrocarvone + H(+) + NADPH + O2 => (4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)"}
{"X":44475,"RHEA_ID":52826,"compounds":"(4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+) => (1R,4R)-dihydrocarvone + H(+) + NADPH + O2"}
{"X":44476,"RHEA_ID":42840,"DIRECTION":"UN","MASTER_ID":42840,"ec":"2.3.1.237","metacyc":"RXN-15689","compounds":"acetyl-CoA + 6 H(+) + 5 malonyl-CoA + 2 NADPH = 2-hydroxy-5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 3 H2O + 2 NADP(+)"}
{"X":44477,"RHEA_ID":42841,"compounds":"acetyl-CoA + 6 H(+) + 5 malonyl-CoA + 2 NADPH => 2-hydroxy-5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 3 H2O + 2 NADP(+)"}
{"X":44478,"RHEA_ID":52829,"compounds":"(1S,4R)-isodihydrocarvone + H(+) + NADPH + O2 => (3S,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)"}
{"X":44479,"RHEA_ID":46146,"compounds":"(24R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":44480,"RHEA_ID":42844,"DIRECTION":"UN","MASTER_ID":42844,"ec":"2.3.1.240","compounds":"6 (S)-methylmalonyl-CoA + 12 H(+) + malonyl-CoA + 5 NADPH = 7 CO2 + 7 CoA + 2 H2O + 5 NADP(+) + narbonolide"}
{"X":44481,"RHEA_ID":42845,"DIRECTION":"LR","MASTER_ID":42844,"metacyc":"RXN-15105","compounds":"6 (S)-methylmalonyl-CoA + 12 H(+) + malonyl-CoA + 5 NADPH => 7 CO2 + 7 CoA + 2 H2O + 5 NADP(+) + narbonolide"}
{"X":44482,"RHEA_ID":52833,"DIRECTION":"LR","MASTER_ID":52832,"metacyc":"RXN-15253","compounds":"1-hydroxylimonen-2-one + H(+) + NADPH + O2 => 7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)"}
{"X":44483,"RHEA_ID":46150,"compounds":"a 2'-deoxyribonucleoside + H(+) + triphosphate => a 2'-deoxyribonucleoside 5'-triphosphate + H2O"}
{"X":44484,"RHEA_ID":42848,"DIRECTION":"UN","MASTER_ID":42848,"ec":"2.4.1.331","compounds":"8-demethyltetracenomycin C + dTDP-beta-L-rhamnose = 8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + dTDP + H(+)"}
{"X":44485,"RHEA_ID":52836,"compounds":"H(+) + indole + NADH + O2 = H2O + indoxyl + NAD(+)"}
{"X":44486,"RHEA_ID":52837,"DIRECTION":"LR","MASTER_ID":52836,"metacyc":"RXN-14713","compounds":"H(+) + indole + NADH + O2 => H2O + indoxyl + NAD(+)"}
{"X":44487,"RHEA_ID":52838,"compounds":"H2O + indoxyl + NAD(+) => H(+) + indole + NADH + O2"}
{"X":44488,"RHEA_ID":42852,"DIRECTION":"UN","MASTER_ID":42852,"ec":"2.3.1.244","compounds":"3 H(+) + holo-[2-methylbutanoate polyketide synthase] + 2 malonyl-CoA + 2 NADPH + S-adenosyl-L-methionine = (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CO2 + 2 CoA + H2O + 2 NADP(+) + S-adenosyl-L-homocysteine"}
{"X":44489,"RHEA_ID":52840,"DIRECTION":"UN","MASTER_ID":52840,"ec":"2.4.1.136","compounds":"4-hydroxy-3-methoxybenzoate + UDP-alpha-D-glucose = 1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + UDP"}
{"X":44490,"RHEA_ID":52841,"compounds":"4-hydroxy-3-methoxybenzoate + UDP-alpha-D-glucose => 1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + UDP"}
{"X":44491,"RHEA_ID":46158,"compounds":"9,9',15-tri-cis-zeta-carotene + a plastoquinol => 15,9'-di-cis-phytofluene + a plastoquinone"}
{"X":44492,"RHEA_ID":42856,"compounds":"1,2-dioctanoyl-sn-glycero-3-diphosphate + H2O = 1,2-dioctanoyl-sn-glycero-3-phosphate + H(+) + phosphate"}
{"X":44493,"RHEA_ID":42857,"compounds":"1,2-dioctanoyl-sn-glycero-3-diphosphate + H2O => 1,2-dioctanoyl-sn-glycero-3-phosphate + H(+) + phosphate"}
{"X":44494,"RHEA_ID":52845,"compounds":"3,4-dihydroxybenzoate + UDP-alpha-D-glucose => 1-O-(3,4-dihydroxy-benzoyl)-beta-D-glucose + UDP"}
{"X":44495,"RHEA_ID":52846,"compounds":"1-O-(3,4-dihydroxy-benzoyl)-beta-D-glucose + UDP => 3,4-dihydroxybenzoate + UDP-alpha-D-glucose"}
{"X":44496,"RHEA_ID":42860,"compounds":"1,2-dioctanoyl-sn-glycero-3-phosphate + H2O = 1,2-dioctanoyl-sn-glycerol + phosphate"}
{"X":44497,"RHEA_ID":52848,"compounds":"5-hydroxyuridine(34) in tRNA + carboxy-S-adenosyl-L-methionine = 5-carboxymethoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":44498,"RHEA_ID":52849,"DIRECTION":"LR","MASTER_ID":52848,"ecocyc":"RXN0-7067","metacyc":"RXN0-7067","compounds":"5-hydroxyuridine(34) in tRNA + carboxy-S-adenosyl-L-methionine => 5-carboxymethoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":44499,"RHEA_ID":52850,"compounds":"5-carboxymethoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine => 5-hydroxyuridine(34) in tRNA + carboxy-S-adenosyl-L-methionine"}
{"X":44500,"RHEA_ID":42864,"DIRECTION":"UN","MASTER_ID":42864,"ec":"2.5.1.126","compounds":"norspermidine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + norspermine + S-methyl-5'-thioadenosine"}
{"X":44501,"RHEA_ID":52852,"DIRECTION":"UN","MASTER_ID":52852,"ec":"1.14.14.46","compounds":"a C2-C8-saturated long-chain fatty acyl-[ACP] + 3 O2 + 2 reduced [flavodoxin] = 6-carboxyhexanoyl-[ACP] + a fatty aldehyde + 3 H(+) + 3 H2O + 2 oxidized [flavodoxin]"}
{"X":44502,"RHEA_ID":52853,"DIRECTION":"LR","MASTER_ID":52852,"metacyc":"RXN-13834","compounds":"a C2-C8-saturated long-chain fatty acyl-[ACP] + 3 O2 + 2 reduced [flavodoxin] => 6-carboxyhexanoyl-[ACP] + a fatty aldehyde + 3 H(+) + 3 H2O + 2 oxidized [flavodoxin]"}
{"X":44503,"RHEA_ID":42867,"DIRECTION":"BI","MASTER_ID":42864,"metacyc":"RXN-15698","compounds":"norspermidine + S-adenosyl 3-(methylsulfanyl)propylamine <=> H(+) + norspermine + S-methyl-5'-thioadenosine"}
{"X":44504,"RHEA_ID":42868,"DIRECTION":"UN","MASTER_ID":42868,"ec":"2.5.1.127","compounds":"norspermine + S-adenosyl 3-(methylsulfanyl)propylamine = caldopentamine + 2 H(+) + S-methyl-5'-thioadenosine"}
{"X":44505,"RHEA_ID":42869,"compounds":"norspermine + S-adenosyl 3-(methylsulfanyl)propylamine => caldopentamine + 2 H(+) + S-methyl-5'-thioadenosine"}
{"X":44506,"RHEA_ID":42870,"compounds":"caldopentamine + 2 H(+) + S-methyl-5'-thioadenosine => norspermine + S-adenosyl 3-(methylsulfanyl)propylamine"}
{"X":44507,"RHEA_ID":42871,"DIRECTION":"BI","MASTER_ID":42868,"metacyc":"RXN-15699","compounds":"norspermine + S-adenosyl 3-(methylsulfanyl)propylamine <=> caldopentamine + 2 H(+) + S-methyl-5'-thioadenosine"}
{"X":44508,"RHEA_ID":42872,"compounds":"N(4)-aminopropylspermidine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + N(4)-bis(aminopropyl)spermidine + S-methyl-5'-thioadenosine"}
{"X":44509,"RHEA_ID":52860,"compounds":"a short-chain fatty acid + ATP + CoA = a short chain fatty acyl-CoA + AMP + diphosphate"}
{"X":44510,"RHEA_ID":52861,"compounds":"a short-chain fatty acid + ATP + CoA => a short chain fatty acyl-CoA + AMP + diphosphate"}
{"X":44511,"RHEA_ID":52862,"compounds":"a short chain fatty acyl-CoA + AMP + diphosphate => a short-chain fatty acid + ATP + CoA"}
{"X":44512,"RHEA_ID":42876,"compounds":"S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = H(+) + N(4)-aminopropylspermidine + S-methyl-5'-thioadenosine"}
{"X":44513,"RHEA_ID":52864,"compounds":"an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)"}
{"X":44514,"RHEA_ID":52865,"DIRECTION":"LR","MASTER_ID":52864,"metacyc":"RXN-18261","compounds":"an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP-beta-L-fucose => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)"}
{"X":44515,"RHEA_ID":52866,"compounds":"an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+) => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP-beta-L-fucose"}
{"X":44516,"RHEA_ID":42880,"compounds":"S-adenosyl 3-(methylsulfanyl)propylamine + spermine = H(+) + N(4)-aminopropylspermine + S-methyl-5'-thioadenosine"}
{"X":44517,"RHEA_ID":52868,"compounds":"17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":44518,"RHEA_ID":52869,"compounds":"17alpha-estradiol + UDP-alpha-D-glucuronate => 17alpha-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":44519,"RHEA_ID":42883,"compounds":"S-adenosyl 3-(methylsulfanyl)propylamine + spermine <=> H(+) + N(4)-aminopropylspermine + S-methyl-5'-thioadenosine"}
{"X":44520,"RHEA_ID":42884,"DIRECTION":"UN","MASTER_ID":42884,"ec":"2.7.1.185","compounds":"(R)-mevalonate + ATP = (R)-3-phosphomevalonate + ADP + H(+)"}
{"X":44521,"RHEA_ID":42885,"DIRECTION":"LR","MASTER_ID":42884,"metacyc":"RXN-15647","compounds":"(R)-mevalonate + ATP => (R)-3-phosphomevalonate + ADP + H(+)"}
{"X":44522,"RHEA_ID":56214,"compounds":"3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP => O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":44523,"RHEA_ID":52874,"compounds":"17alpha-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP => 17alpha-estradiol + UDP-alpha-D-glucuronate"}
{"X":44524,"RHEA_ID":42888,"DIRECTION":"UN","MASTER_ID":42888,"ec":"2.7.1.186","compounds":"(R)-3-phosphomevalonate + ATP = (R)-3,5-bisphosphomevalonate + ADP + H(+)"}
{"X":44525,"RHEA_ID":42889,"DIRECTION":"LR","MASTER_ID":42888,"metacyc":"RXN-15648","compounds":"(R)-3-phosphomevalonate + ATP => (R)-3,5-bisphosphomevalonate + ADP + H(+)"}
{"X":44526,"RHEA_ID":56218,"compounds":"3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP => O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":44527,"RHEA_ID":52878,"compounds":"16beta,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP => 16beta,17beta-estriol + UDP-alpha-D-glucuronate"}
{"X":44528,"RHEA_ID":42892,"DIRECTION":"UN","MASTER_ID":42892,"ec":"3.5.4.41","compounds":"5'-deoxyadenosine + H(+) + H2O = 5'-deoxyinosine + NH4(+)"}
{"X":44529,"RHEA_ID":42893,"compounds":"5'-deoxyadenosine + H(+) + H2O => 5'-deoxyinosine + NH4(+)"}
{"X":44530,"RHEA_ID":42894,"compounds":"5'-deoxyinosine + NH4(+) => 5'-deoxyadenosine + H(+) + H2O"}
{"X":44531,"RHEA_ID":52882,"compounds":"16beta,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP => 16beta,17beta-estriol + UDP-alpha-D-glucuronate"}
{"X":44532,"RHEA_ID":42896,"DIRECTION":"UN","MASTER_ID":42896,"ec":"2.1.1.297","compounds":"L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine"}
{"X":44533,"RHEA_ID":42897,"DIRECTION":"LR","MASTER_ID":42896,"ecocyc":"RXN-14992","metacyc":"RXN-14992","compounds":"L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine => H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine"}
{"X":44534,"RHEA_ID":52885,"compounds":"H2O + N-phenylhydroxylamine + 2 NADP(+) => 2 H(+) + 2 NADPH + nitrobenzene"}
{"X":44535,"RHEA_ID":52886,"DIRECTION":"RL","MASTER_ID":52884,"metacyc":"RXN-8815","compounds":"2 H(+) + 2 NADPH + nitrobenzene => H2O + N-phenylhydroxylamine + 2 NADP(+)"}
{"X":44536,"RHEA_ID":46200,"compounds":"5alpha-androstane-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase] = 5alpha-androstane-3beta,6alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":44537,"RHEA_ID":42901,"DIRECTION":"LR","MASTER_ID":42900,"ecocyc":"RXN-11573","metacyc":"RXN-11573","compounds":"guanosine(745) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylguanosine(745) in 23S rRNA + S-adenosyl-L-homocysteine"}
{"X":44538,"RHEA_ID":52889,"compounds":"N-phenylhydroxylamine + NADP(+) => H(+) + NADPH + nitrosobenzene"}
{"X":44539,"RHEA_ID":52890,"DIRECTION":"RL","MASTER_ID":52888,"metacyc":"RXN-18437","compounds":"H(+) + NADPH + nitrosobenzene => N-phenylhydroxylamine + NADP(+)"}
{"X":44540,"RHEA_ID":42904,"DIRECTION":"UN","MASTER_ID":42904,"ec":"2.1.1.188","compounds":"guanosine(748) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(748) in 23S rRNA + S-adenosyl-L-homocysteine"}
{"X":44541,"RHEA_ID":42905,"DIRECTION":"LR","MASTER_ID":42904,"metacyc":"RXN-11599","compounds":"guanosine(748) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylguanosine(748) in 23S rRNA + S-adenosyl-L-homocysteine"}
{"X":44542,"RHEA_ID":52893,"compounds":"H2O + NADP(+) + nitrosobenzene => H(+) + NADPH + nitrobenzene"}
{"X":44543,"RHEA_ID":52894,"DIRECTION":"RL","MASTER_ID":52892,"metacyc":"RXN-18436","compounds":"H(+) + NADPH + nitrobenzene => H2O + NADP(+) + nitrosobenzene"}
{"X":44544,"RHEA_ID":46208,"compounds":"ATP + CoA + eicosanoate = AMP + diphosphate + eicosanoyl-CoA"}
{"X":44545,"RHEA_ID":42909,"DIRECTION":"LR","MASTER_ID":42908,"ecocyc":"RXN-11601","metacyc":"RXN-11601","compounds":"S-adenosyl-L-methionine + uridine(1939) in 23S rRNA => 5-methyluridine(1939) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":44546,"RHEA_ID":42910,"compounds":"5-methyluridine(1939) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(1939) in 23S rRNA"}
{"X":44547,"RHEA_ID":56237,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine"}
{"X":44548,"RHEA_ID":46212,"compounds":"H2O + N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine = 4-amino-5-aminomethyl-2-methylpyrimidine + formate"}
{"X":44549,"RHEA_ID":42913,"DIRECTION":"LR","MASTER_ID":42912,"ecocyc":"RXN-11602","metacyc":"RXN-11602","compounds":"cytidine(1962) in 23S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(1962) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":44550,"RHEA_ID":42914,"compounds":"5-methylcytidine(1962) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1962) in 23S rRNA + S-adenosyl-L-methionine"}
{"X":44551,"RHEA_ID":56241,"compounds":"1,2-dioctanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] => 2-octanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl octanoate + apo--[retinol-binding protein]"}
{"X":44552,"RHEA_ID":46216,"compounds":"H(+) + NADPH + progesterone = 3beta-hydroxypregn-4-ene-20-one + NADP(+)"}
{"X":44553,"RHEA_ID":42917,"DIRECTION":"LR","MASTER_ID":42916,"ecocyc":"RXN-11586","metacyc":"RXN-11586","compounds":"adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine => 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine"}
{"X":44554,"RHEA_ID":42918,"compounds":"2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine => adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine"}
{"X":44555,"RHEA_ID":56245,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] => 2-hexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl hexadecanoate + apo--[retinol-binding protein]"}
{"X":44556,"RHEA_ID":46220,"compounds":"androst-5-en-3beta,17beta-diol + NAD(+) = 3beta-hydroxyandrost-5-en-17-one + H(+) + NADH"}
{"X":44557,"RHEA_ID":42921,"DIRECTION":"LR","MASTER_ID":42920,"ecocyc":"RXN-11598","metacyc":"RXN-11598","compounds":"S-adenosyl-L-methionine + uridine(1498) in 16S rRNA => H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine"}
{"X":44558,"RHEA_ID":42922,"compounds":"H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(1498) in 16S rRNA"}
{"X":44559,"RHEA_ID":42923,"compounds":"S-adenosyl-L-methionine + uridine(1498) in 16S rRNA <=> H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine"}
{"X":44560,"RHEA_ID":46224,"compounds":"(E)-feruloyl-CoA + H2O = CoA + H(+) + trans-ferulate"}
{"X":44561,"RHEA_ID":42925,"DIRECTION":"LR","MASTER_ID":42924,"ecocyc":"RXN-11637","metacyc":"RXN-11637","compounds":"cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":44562,"RHEA_ID":42926,"compounds":"2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine"}
{"X":44563,"RHEA_ID":42927,"compounds":"cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":44564,"RHEA_ID":46228,"compounds":"apo-[peptidyl-carrier protein] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[peptidyl-carrier protein]"}
{"X":44565,"RHEA_ID":42929,"DIRECTION":"LR","MASTER_ID":42928,"ecocyc":"RXN-11638","metacyc":"RXN-11638","compounds":"cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine => H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine"}
{"X":44566,"RHEA_ID":42930,"compounds":"H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine => cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine"}
{"X":44567,"RHEA_ID":42931,"compounds":"cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine <=> H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine"}
{"X":44568,"RHEA_ID":46232,"compounds":"(9Z,12Z)-hexadecadienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (9Z,12Z,15Z)-hexadecatrienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":44569,"RHEA_ID":42933,"DIRECTION":"LR","MASTER_ID":42932,"ecocyc":"RXN-11866","metacyc":"RXN-11866","compounds":"cytidine(32) in tRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":44570,"RHEA_ID":42934,"compounds":"2'-O-methylcytidine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(32) in tRNA + S-adenosyl-L-methionine"}
{"X":44571,"RHEA_ID":42935,"compounds":"cytidine(32) in tRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":44572,"RHEA_ID":46236,"DIRECTION":"UN","MASTER_ID":46236,"ec":"1.14.19.12","compounds":"2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a (5Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 H2O"}
{"X":44573,"RHEA_ID":42937,"DIRECTION":"LR","MASTER_ID":42936,"ecocyc":"RXN-11867","metacyc":"RXN-11867","compounds":"S-adenosyl-L-methionine + uridine(32) in tRNA => 2'-O-methyluridine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":44574,"RHEA_ID":42938,"compounds":"2'-O-methyluridine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(32) in tRNA"}
{"X":44575,"RHEA_ID":42939,"compounds":"S-adenosyl-L-methionine + uridine(32) in tRNA <=> 2'-O-methyluridine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":44576,"RHEA_ID":52927,"compounds":"16alpha,17alpha-estriol + UDP-alpha-D-glucuronate <=> 16alpha,17alpha-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":44577,"RHEA_ID":42940,"DIRECTION":"UN","MASTER_ID":42940,"ec":"2.1.1.203","compounds":"cytidine(34) in tRNA precursor + S-adenosyl-L-methionine = 5-methylcytidine(34) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine"}
{"X":44578,"RHEA_ID":42941,"DIRECTION":"LR","MASTER_ID":42940,"metacyc":"RXN-11856","compounds":"cytidine(34) in tRNA precursor + S-adenosyl-L-methionine => 5-methylcytidine(34) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine"}
{"X":44579,"RHEA_ID":56269,"DIRECTION":"LR","MASTER_ID":56268,"metacyc":"RXN-19003","compounds":"CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => CMP + H(+) + N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]"}
{"X":44580,"RHEA_ID":46244,"DIRECTION":"UN","MASTER_ID":46244,"ec":"1.14.19.32","compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 = (14E)-hexadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":44581,"RHEA_ID":42944,"DIRECTION":"UN","MASTER_ID":42944,"ec":"2.1.1.202","compounds":"cytidine(40) in tRNA precursor + S-adenosyl-L-methionine = 5-methylcytidine(40) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine"}
{"X":44582,"RHEA_ID":42945,"DIRECTION":"LR","MASTER_ID":42944,"metacyc":"RXN-11857","compounds":"cytidine(40) in tRNA precursor + S-adenosyl-L-methionine => 5-methylcytidine(40) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine"}
{"X":44583,"RHEA_ID":42946,"compounds":"5-methylcytidine(40) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine => cytidine(40) in tRNA precursor + S-adenosyl-L-methionine"}
{"X":44584,"RHEA_ID":46248,"DIRECTION":"UN","MASTER_ID":46248,"ec":"1.14.19.32","compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 = (14Z)-hexadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":44585,"RHEA_ID":42948,"DIRECTION":"UN","MASTER_ID":42948,"ec":"2.1.1.202","compounds":"cytidine(48) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(48) in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":44586,"RHEA_ID":42949,"DIRECTION":"LR","MASTER_ID":42948,"metacyc":"RXN-11858","compounds":"cytidine(48) in tRNA + S-adenosyl-L-methionine => 5-methylcytidine(48) in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":44587,"RHEA_ID":56277,"DIRECTION":"LR","MASTER_ID":56276,"metacyc":"RXN-19079","compounds":"ATP + L-proline => 3'-L-prolyl-AMP + diphosphate"}
{"X":44588,"RHEA_ID":56278,"compounds":"3'-L-prolyl-AMP + diphosphate => ATP + L-proline"}
{"X":44589,"RHEA_ID":42952,"DIRECTION":"UN","MASTER_ID":42952,"ec":"2.1.1.202","compounds":"cytidine(49) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(49) in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":44590,"RHEA_ID":56280,"compounds":"3'-L-prolyl-AMP + holo-[peptidyl-carrier protein] = AMP + L-prolyl-[peptidyl-carrier protein]"}
{"X":44591,"RHEA_ID":46255,"compounds":"2 [Fe(II)-cytochrome b5] + a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-containing glycerolipid + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-containing glycerolipid + 2 H2O"}
{"X":44592,"RHEA_ID":56282,"compounds":"AMP + L-prolyl-[peptidyl-carrier protein] => 3'-L-prolyl-AMP + holo-[peptidyl-carrier protein]"}
{"X":44593,"RHEA_ID":42956,"DIRECTION":"UN","MASTER_ID":42956,"ec":"2.1.1.204","compounds":"cytidine(38) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(38) in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":44594,"RHEA_ID":42957,"DIRECTION":"LR","MASTER_ID":42956,"metacyc":"RXN-11855","compounds":"cytidine(38) in tRNA + S-adenosyl-L-methionine => 5-methylcytidine(38) in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":44595,"RHEA_ID":56285,"compounds":"a (3R,4R)-4,2'-dihydroxyisoflavan + NADP(+) => a (3R)-2'-hydroxyisoflavanone + H(+) + NADPH"}
{"X":44596,"RHEA_ID":56286,"DIRECTION":"RL","MASTER_ID":56284,"metacyc":"RXN-18747","compounds":"a (3R)-2'-hydroxyisoflavanone + H(+) + NADPH => a (3R,4R)-4,2'-dihydroxyisoflavan + NADP(+)"}
{"X":44597,"RHEA_ID":42960,"compounds":"H(+) + NAD(+) + 2 reduced [nitric oxide reductase rubredoxin domain] = NADH + 2 oxidized [nitric oxide reductase rubredoxin domain]"}
{"X":44598,"RHEA_ID":42961,"compounds":"H(+) + NAD(+) + 2 reduced [nitric oxide reductase rubredoxin domain] => NADH + 2 oxidized [nitric oxide reductase rubredoxin domain]"}
{"X":44599,"RHEA_ID":56289,"DIRECTION":"LR","MASTER_ID":56288,"metacyc":"RXN-19052","compounds":"albendazole + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + hydroxyalbendazole + oxidized [NADPH--hemoprotein reductase]"}
{"X":44600,"RHEA_ID":56290,"compounds":"H(+) + H2O + hydroxyalbendazole + oxidized [NADPH--hemoprotein reductase] => albendazole + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":44601,"RHEA_ID":42964,"compounds":"uridine(54/55) in tRNA = pseudouridine(54/55) in tRNA"}
{"X":44602,"RHEA_ID":42965,"compounds":"uridine(54/55) in tRNA => pseudouridine(54/55) in tRNA"}
{"X":44603,"RHEA_ID":56293,"DIRECTION":"LR","MASTER_ID":56292,"metacyc":"RXN-19053","compounds":"fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] => 4'-hydroxyfenbendazole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":44604,"RHEA_ID":46268,"DIRECTION":"UN","MASTER_ID":46268,"ec":"1.14.19.29","compounds":"2 [Fe(II)-cytochrome b5] + an N-acyl-(4R)-4-hydroxysphinganine + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a (4R,8E)-4-hydroxysphingenine ceramide + 2 H2O"}
{"X":44605,"RHEA_ID":42968,"DIRECTION":"UN","MASTER_ID":42968,"ec":"2.1.1.206","compounds":"cytidine(56) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(56) in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":44606,"RHEA_ID":42969,"DIRECTION":"LR","MASTER_ID":42968,"metacyc":"RXN-11869","compounds":"cytidine(56) in tRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(56) in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":44607,"RHEA_ID":42970,"compounds":"2'-O-methylcytidine(56) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(56) in tRNA + S-adenosyl-L-methionine"}
{"X":44608,"RHEA_ID":56298,"compounds":"pyruvate + S-sulfanyl-L-cysteinyl-[protein] => 3-mercaptopyruvate + L-cysteinyl-[protein]"}
{"X":44609,"RHEA_ID":42972,"compounds":"1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a cardiolipin + ethanolamine"}
{"X":44610,"RHEA_ID":42973,"DIRECTION":"LR","MASTER_ID":42972,"ecocyc":"RXN0-7012","metacyc":"RXN0-7012","compounds":"1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine => a cardiolipin + ethanolamine"}
{"X":44611,"RHEA_ID":56302,"compounds":"[thioredoxin]-disulfide + H(+) + hydrogen sulfide + L-cysteinyl-[protein] => [thioredoxin]-dithiol + S-sulfanyl-L-cysteinyl-[protein]"}
{"X":44612,"RHEA_ID":42976,"compounds":"L-tryptophan = 2-aminoprop-2-enoate + indole"}
{"X":44613,"RHEA_ID":42977,"compounds":"L-tryptophan => 2-aminoprop-2-enoate + indole"}
{"X":44614,"RHEA_ID":42978,"compounds":"2-aminoprop-2-enoate + indole => L-tryptophan"}
{"X":44615,"RHEA_ID":52971,"compounds":"hyocholate + UDP-alpha-D-glucuronate <=> H(+) + hyocholate 6-O-(beta-D-glucuronate) + UDP"}
{"X":44616,"RHEA_ID":42980,"compounds":"L-tyrosine = 2-aminoprop-2-enoate + phenol"}
{"X":44617,"RHEA_ID":52973,"DIRECTION":"LR","MASTER_ID":52972,"metacyc":"RXN-13835","compounds":"a C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] => a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin]"}
{"X":44618,"RHEA_ID":42982,"compounds":"2-aminoprop-2-enoate + phenol => L-tyrosine"}
{"X":44619,"RHEA_ID":46284,"DIRECTION":"UN","MASTER_ID":46284,"ec":"1.14.19.47","compounds":"2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 = (6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":44620,"RHEA_ID":42984,"DIRECTION":"UN","MASTER_ID":42984,"ec":"4.2.3.147","compounds":"(+)-copalyl diphosphate = diphosphate + pimara-8(14),15-diene"}
{"X":44621,"RHEA_ID":52977,"DIRECTION":"LR","MASTER_ID":52976,"metacyc":"RXN-13836","compounds":"a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] => a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin]"}
{"X":44622,"RHEA_ID":46287,"compounds":"2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 <=> (6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":44623,"RHEA_ID":46288,"DIRECTION":"UN","MASTER_ID":46288,"ec":"1.14.19.47","compounds":"(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":44624,"RHEA_ID":42988,"DIRECTION":"UN","MASTER_ID":42988,"ec":"4.2.3.148","compounds":"all-trans-geranylgeranyl diphosphate = cembrene C + diphosphate"}
{"X":44625,"RHEA_ID":52981,"DIRECTION":"LR","MASTER_ID":52980,"metacyc":"RXN-13991","compounds":"a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] => 7-oxoheptanoyl-[ACP] + a fatty aldehyde + H(+) + 2 H2O + oxidized [flavodoxin]"}
{"X":44626,"RHEA_ID":42990,"compounds":"cembrene C + diphosphate => all-trans-geranylgeranyl diphosphate"}
{"X":44627,"RHEA_ID":56318,"compounds":"3-acetylamino-4-hydroxybenzoate + CoA => 3-amino-4-hydroxybenzoate + acetyl-CoA"}
{"X":44628,"RHEA_ID":42992,"DIRECTION":"UN","MASTER_ID":42992,"ec":"4.2.3.149","compounds":"all-trans-geranylgeranyl diphosphate + H2O = (R)-nephthenol + diphosphate"}
{"X":44629,"RHEA_ID":46294,"compounds":"a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + diphosphate => a 5'-end triphospho-(purine-ribonucleotide) in mRNA + GDP + H(+)"}
{"X":44630,"RHEA_ID":42994,"compounds":"(R)-nephthenol + diphosphate => all-trans-geranylgeranyl diphosphate + H2O"}
{"X":44631,"RHEA_ID":52987,"compounds":"7-oxoheptanoyl-[ACP] + H2O + oxidized [flavodoxin] <=> 6-carboxyhexanoyl-[ACP] + reduced [flavodoxin]"}
{"X":44632,"RHEA_ID":42996,"DIRECTION":"UN","MASTER_ID":42996,"ec":"4.2.3.150","compounds":"all-trans-geranylgeranyl diphosphate = (R)-cembrene A + diphosphate"}
{"X":44633,"RHEA_ID":56324,"DIRECTION":"UN","MASTER_ID":56324,"ec":"2.1.1.n11","compounds":"a methylphosphotriester deoxyribonucleoside in DNA + L-cysteinyl-[protein] = a deoxyribonucleotide in DNA + H(+) + S-methyl-L-cysteinyl-[protein]"}
{"X":44634,"RHEA_ID":42998,"compounds":"(R)-cembrene A + diphosphate => all-trans-geranylgeranyl diphosphate"}
{"X":44635,"RHEA_ID":49600,"compounds":"ATP + CoA + octanedioate = AMP + diphosphate + octanedioyl-CoA"}
{"X":44636,"RHEA_ID":43000,"DIRECTION":"UN","MASTER_ID":43000,"ec":"4.2.3.151","compounds":"all-trans-geranylgeranyl diphosphate + H2O = (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol + diphosphate"}
{"X":44637,"RHEA_ID":52993,"DIRECTION":"LR","MASTER_ID":52992,"metacyc":"RXN-13416","compounds":"[deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + [eIF5A protein]-L-lysine => [deoxyhypusine synthase]-L-lysine + [eIF5A protein]-N-(4-aminobutylidene)-L-lysine"}
{"X":44638,"RHEA_ID":43002,"compounds":"(1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol + diphosphate => all-trans-geranylgeranyl diphosphate + H2O"}
{"X":44639,"RHEA_ID":56330,"compounds":"5'-triphosphoadenylyl-(2'->5')-adenosine + AMP + H(+) => 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + H2O"}
{"X":44640,"RHEA_ID":43004,"compounds":"H(+) + O-carbamoyl-L-serine = 2-aminoprop-2-enoate + CO2 + NH4(+)"}
{"X":44641,"RHEA_ID":52997,"DIRECTION":"LR","MASTER_ID":52996,"metacyc":"RXN-13417","compounds":"[eIF5A protein]-N-(4-aminobutylidene)-L-lysine + H(+) + NADH => [eIF5A protein]-deoxyhypusine + NAD(+)"}
{"X":44642,"RHEA_ID":43006,"compounds":"2-aminoprop-2-enoate + CO2 + NH4(+) => H(+) + O-carbamoyl-L-serine"}
{"X":44643,"RHEA_ID":43008,"compounds":"D-serine = 2-aminoprop-2-enoate + H2O"}
{"X":44644,"RHEA_ID":53001,"compounds":"17beta-hydroxy-5alpha-androstan-3-one + UDP-alpha-D-glucuronate => 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":44645,"RHEA_ID":43010,"compounds":"2-aminoprop-2-enoate + H2O => D-serine"}
{"X":44646,"RHEA_ID":53003,"compounds":"17beta-hydroxy-5alpha-androstan-3-one + UDP-alpha-D-glucuronate <=> 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":44647,"RHEA_ID":43012,"compounds":"L-homocysteine = 2-aminobut-2-enoate + H(+) + hydrogen sulfide"}
{"X":44648,"RHEA_ID":53005,"compounds":"2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate => 2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":44649,"RHEA_ID":43014,"compounds":"2-aminobut-2-enoate + H(+) + hydrogen sulfide => L-homocysteine"}
{"X":44650,"RHEA_ID":56342,"compounds":"ent-isokaurene-2beta,3beta-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-isokauren-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":44651,"RHEA_ID":43016,"compounds":"an S-alkyl-L-cysteine = 2-aminoprop-2-enoate + an alkyl thiol"}
{"X":44652,"RHEA_ID":56344,"DIRECTION":"UN","MASTER_ID":56344,"ec":"2.4.1.170","compounds":"a 7-hydroxyisoflavone + UDP-alpha-D-glucose = a 7-hydroxyisoflavone 7-O-beta-D-glucoside + H(+) + UDP"}
{"X":44653,"RHEA_ID":43018,"compounds":"2-aminoprop-2-enoate + an alkyl thiol => an S-alkyl-L-cysteine"}
{"X":44654,"RHEA_ID":43020,"compounds":"L,L-cystathionine = 2-aminoprop-2-enoate + L-homocysteine"}
{"X":44655,"RHEA_ID":53013,"compounds":"2,5-dichlorohydroquinone + 2 glutathione => chloride + chlorohydroquinone + glutathione disulfide + H(+)"}
{"X":44656,"RHEA_ID":43022,"compounds":"2-aminoprop-2-enoate + L-homocysteine => L,L-cystathionine"}
{"X":44657,"RHEA_ID":43023,"compounds":"L,L-cystathionine <=> 2-aminoprop-2-enoate + L-homocysteine"}
{"X":44658,"RHEA_ID":53016,"compounds":"chlorohydroquinone + 2 glutathione = chloride + glutathione disulfide + H(+) + hydroquinone"}
{"X":44659,"RHEA_ID":53017,"compounds":"chlorohydroquinone + 2 glutathione => chloride + glutathione disulfide + H(+) + hydroquinone"}
{"X":44660,"RHEA_ID":43026,"compounds":"2-aminoprop-2-enoate + a thiol => an S-substituted L-cysteine"}
{"X":44661,"RHEA_ID":43027,"compounds":"an S-substituted L-cysteine <=> 2-aminoprop-2-enoate + a thiol"}
{"X":44662,"RHEA_ID":43028,"compounds":"L-cysteate = 2-aminoprop-2-enoate + H(+) + sulfite"}
{"X":44663,"RHEA_ID":46330,"compounds":"3-phenylpyruvate + NH4(+) => L-threo-3-phenylserine"}
{"X":44664,"RHEA_ID":43030,"compounds":"2-aminoprop-2-enoate + H(+) + sulfite => L-cysteate"}
{"X":44665,"RHEA_ID":43031,"DIRECTION":"BI","MASTER_ID":43028,"metacyc":"RXN-15583","compounds":"L-cysteate <=> 2-aminoprop-2-enoate + H(+) + sulfite"}
{"X":44666,"RHEA_ID":53024,"compounds":"a plastoquinone + H2O + L-arginine = 5-guanidino-2-oxopentanoate + a plastoquinol + NH4(+)"}
{"X":44667,"RHEA_ID":46334,"compounds":"2 [Fe(III)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H2O => 2 [Fe(II)-cytochrome b5] + a (9Z)-octadecenoyl-containing glycerolipid + 2 H(+) + O2"}
{"X":44668,"RHEA_ID":43034,"compounds":"2-aminoprop-2-enoate + chloride + H(+) => 3-chloro-D-alanine"}
{"X":44669,"RHEA_ID":43035,"compounds":"3-chloro-D-alanine <=> 2-aminoprop-2-enoate + chloride + H(+)"}
{"X":44670,"RHEA_ID":43036,"compounds":"L-cysteine = 2-aminoprop-2-enoate + H(+) + hydrogen sulfide"}
{"X":44671,"RHEA_ID":46338,"compounds":"17-hydroxy-3-oxochol-4-en-22-oyl-CoA => 3-oxochola-4,17-dien-22-oyl-CoA + H2O"}
{"X":44672,"RHEA_ID":43038,"compounds":"2-aminoprop-2-enoate + H(+) + hydrogen sulfide => L-cysteine"}
{"X":44673,"RHEA_ID":43039,"compounds":"L-cysteine <=> 2-aminoprop-2-enoate + H(+) + hydrogen sulfide"}
{"X":44674,"RHEA_ID":53032,"compounds":"2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 2-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":44675,"RHEA_ID":53033,"compounds":"2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate => 17beta-estradiol 2-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":44676,"RHEA_ID":43042,"compounds":"CoA + H(+) + N-hexadecanoylhexadecasphinganine => hexadecanoyl-CoA + hexadecasphinganine"}
{"X":44677,"RHEA_ID":43043,"compounds":"hexadecanoyl-CoA + hexadecasphinganine <=> CoA + H(+) + N-hexadecanoylhexadecasphinganine"}
{"X":44678,"RHEA_ID":53036,"compounds":"4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 4-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":44679,"RHEA_ID":53037,"compounds":"4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate => 4-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":44680,"RHEA_ID":43046,"compounds":"CoA + H(+) + N-octadecanoylhexadecasphinganine => hexadecasphinganine + octadecanoyl-CoA"}
{"X":44681,"RHEA_ID":43047,"compounds":"hexadecasphinganine + octadecanoyl-CoA <=> CoA + H(+) + N-octadecanoylhexadecasphinganine"}
{"X":44682,"RHEA_ID":43048,"DIRECTION":"UN","MASTER_ID":43048,"ec":"5.1.3.31","compounds":"keto-D-tagatose = keto-D-sorbose"}
{"X":44683,"RHEA_ID":53041,"compounds":"4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate => 17beta-estradiol 4-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":44684,"RHEA_ID":43050,"compounds":"keto-D-sorbose => keto-D-tagatose"}
{"X":44685,"RHEA_ID":53043,"compounds":"4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate <=> 17beta-estradiol 4-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":44686,"RHEA_ID":43052,"DIRECTION":"UN","MASTER_ID":43052,"ec":"6.2.1.44","compounds":"3-(methylsulfanyl)propanoate + ATP + CoA = 3-(methylsulfanyl)propanoyl-CoA + AMP + diphosphate"}
{"X":44687,"RHEA_ID":43053,"DIRECTION":"LR","MASTER_ID":43052,"metacyc":"RXN-12571","compounds":"3-(methylsulfanyl)propanoate + ATP + CoA => 3-(methylsulfanyl)propanoyl-CoA + AMP + diphosphate"}
{"X":44688,"RHEA_ID":43054,"compounds":"3-(methylsulfanyl)propanoyl-CoA + AMP + diphosphate => 3-(methylsulfanyl)propanoate + ATP + CoA"}
{"X":44689,"RHEA_ID":46356,"DIRECTION":"UN","MASTER_ID":46356,"ec":"1.14.14.80","compounds":"O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] = 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":44690,"RHEA_ID":53048,"compounds":"2-hydroxyestrone + UDP-alpha-D-glucuronate = 2-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":44691,"RHEA_ID":43057,"DIRECTION":"LR","MASTER_ID":43056,"metacyc":"RXN-15103","compounds":"5 (S)-methylmalonyl-CoA + 11 H(+) + malonyl-CoA + 5 NADPH => 10-deoxymethynolide + 6 CO2 + 6 CoA + 2 H2O + 5 NADP(+)"}
{"X":44692,"RHEA_ID":43058,"compounds":"10-deoxymethynolide + 6 CO2 + 6 CoA + 2 H2O + 5 NADP(+) => 5 (S)-methylmalonyl-CoA + 11 H(+) + malonyl-CoA + 5 NADPH"}
{"X":44693,"RHEA_ID":53051,"compounds":"2-hydroxyestrone + UDP-alpha-D-glucuronate <=> 2-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":44694,"RHEA_ID":53052,"compounds":"4-hydroxyestrone + UDP-alpha-D-glucuronate = 4-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":44695,"RHEA_ID":56388,"compounds":"(5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2 = (4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O"}
{"X":44696,"RHEA_ID":43062,"compounds":"beta-D-glucose 1-phosphate + glycerol => 2-O-(alpha-D-glucopyranosyl)glycerol + phosphate"}
{"X":44697,"RHEA_ID":53055,"compounds":"4-hydroxyestrone + UDP-alpha-D-glucuronate <=> 4-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":44698,"RHEA_ID":53056,"compounds":"4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = H(+) + isowyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine"}
{"X":44699,"RHEA_ID":56392,"DIRECTION":"UN","MASTER_ID":56392,"ec":"3.1.1.75","compounds":"[(3R)-hydroxybutanoate](n) + H2O = (3R)-hydroxybutanoate dimer + [(3R)-hydroxybutanoate](n-2) + H(+)"}
{"X":44700,"RHEA_ID":43066,"compounds":"holo-[2-methylbutanoate polyketide synthase] + lovastatin carboxylate => (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + monacolin J carboxylate"}
{"X":44701,"RHEA_ID":53059,"compounds":"4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine <=> H(+) + isowyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine"}
{"X":44702,"RHEA_ID":53060,"compounds":"4-hydroxyestrone + UDP-alpha-D-glucuronate = estrone 4-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":44703,"RHEA_ID":46370,"compounds":"2 [Fe(III)-cytochrome b5] + a (9Z,11E,13E)-octadecatrienoyl-containing glycerolipid + 2 H2O => 2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2"}
{"X":44704,"RHEA_ID":43070,"compounds":"4 H(+) + 4 H2O + oleanolate + 3 oxidized [NADPH--hemoprotein reductase] => beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]"}
{"X":44705,"RHEA_ID":53063,"compounds":"4-hydroxyestrone + UDP-alpha-D-glucuronate <=> estrone 4-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":44706,"RHEA_ID":53064,"compounds":"2-methoxyestrone + UDP-alpha-D-glucuronate = 2-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":44707,"RHEA_ID":43073,"DIRECTION":"LR","MASTER_ID":43072,"metacyc":"RXN-13503","compounds":"beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => erythrodiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":44708,"RHEA_ID":43074,"compounds":"erythrodiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":44709,"RHEA_ID":53067,"compounds":"2-methoxyestrone + UDP-alpha-D-glucuronate <=> 2-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":44710,"RHEA_ID":53068,"compounds":"4-methoxyestrone + UDP-alpha-D-glucuronate = 4-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":44711,"RHEA_ID":46378,"compounds":"a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a (9Z)-octadecenoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":44712,"RHEA_ID":43078,"compounds":"H(+) + 2 H2O + oleanolic aldehyde + oxidized [NADPH--hemoprotein reductase] => erythrodiol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":44713,"RHEA_ID":53071,"compounds":"4-methoxyestrone + UDP-alpha-D-glucuronate <=> 4-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":44714,"RHEA_ID":43080,"compounds":"O2 + oleanolic aldehyde + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + oleanolate + oxidized [NADPH--hemoprotein reductase]"}
{"X":44715,"RHEA_ID":53073,"compounds":"2-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate => 2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":44716,"RHEA_ID":43082,"compounds":"2 H(+) + H2O + oleanolate + oxidized [NADPH--hemoprotein reductase] => O2 + oleanolic aldehyde + reduced [NADPH--hemoprotein reductase]"}
{"X":44717,"RHEA_ID":53075,"compounds":"2-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate <=> 2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":44718,"RHEA_ID":53076,"compounds":"cytidine(34) in mitochondrial tRNA + S-adenosyl-L-methionine = 5-methylcytidine(34) in mitochondrial tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":44719,"RHEA_ID":46386,"compounds":"24S,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":44720,"RHEA_ID":43086,"compounds":"2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(34) in tRNA + S-adenosyl-L-methionine"}
{"X":44721,"RHEA_ID":43087,"compounds":"cytidine(34) in tRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":44722,"RHEA_ID":53080,"compounds":"4-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate = 4-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":44723,"RHEA_ID":53081,"compounds":"4-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate => 4-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":44724,"RHEA_ID":43090,"compounds":"5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine => 5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine"}
{"X":44725,"RHEA_ID":43091,"compounds":"5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine <=> 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine"}
{"X":44726,"RHEA_ID":53084,"compounds":"[(1->2)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->2)-beta-D-glucosyl](n+1) + H(+) + UDP"}
{"X":44727,"RHEA_ID":43093,"DIRECTION":"LR","MASTER_ID":43092,"metacyc":"RXN-12227","compounds":"S-adenosyl-L-methionine + uridine(2479) in 23S rRNA => 2'-O-methyluridine(2479) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":44728,"RHEA_ID":43094,"compounds":"2'-O-methyluridine(2479) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(2479) in 23S rRNA"}
{"X":44729,"RHEA_ID":43095,"compounds":"S-adenosyl-L-methionine + uridine(2479) in 23S rRNA <=> 2'-O-methyluridine(2479) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":44730,"RHEA_ID":53088,"compounds":"2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine = 2-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine"}
{"X":44731,"RHEA_ID":53089,"compounds":"2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine => 2-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine"}
{"X":44732,"RHEA_ID":43098,"compounds":"H(+) + N(1)-methylguanosine(2535) in 23S rRNA + S-adenosyl-L-homocysteine => guanosine(2535) in 23S rRNA + S-adenosyl-L-methionine"}
{"X":44733,"RHEA_ID":43099,"compounds":"guanosine(2535) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylguanosine(2535) in 23S rRNA + S-adenosyl-L-homocysteine"}
{"X":44734,"RHEA_ID":53092,"compounds":"2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine = 2-hydroxy-3-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine"}
{"X":44735,"RHEA_ID":53093,"compounds":"2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine => 2-hydroxy-3-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine"}
{"X":44736,"RHEA_ID":43102,"compounds":"2'-O-methyluridine(44) in tRNA(Ser) + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(44) in tRNA(Ser)"}
{"X":44737,"RHEA_ID":43103,"compounds":"S-adenosyl-L-methionine + uridine(44) in tRNA(Ser) <=> 2'-O-methyluridine(44) in tRNA(Ser) + H(+) + S-adenosyl-L-homocysteine"}
{"X":44738,"RHEA_ID":53096,"compounds":"4-hydroxy-17beta-estradiol + S-adenosyl-L-methionine = 4-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine"}
{"X":44739,"RHEA_ID":53097,"compounds":"4-hydroxy-17beta-estradiol + S-adenosyl-L-methionine => 4-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine"}
{"X":44740,"RHEA_ID":43106,"compounds":"A + 2 H2O + N-acyleicosasphing-4-enine => AH2 + N-acyleicosasphinganine + O2"}
{"X":44741,"RHEA_ID":43107,"compounds":"AH2 + N-acyleicosasphinganine + O2 <=> A + 2 H2O + N-acyleicosasphing-4-enine"}
{"X":44742,"RHEA_ID":53100,"compounds":"2-hydroxyestrone + S-adenosyl-L-methionine = 2-methoxyestrone + H(+) + S-adenosyl-L-homocysteine"}
{"X":44743,"RHEA_ID":53101,"compounds":"2-hydroxyestrone + S-adenosyl-L-methionine => 2-methoxyestrone + H(+) + S-adenosyl-L-homocysteine"}
{"X":44744,"RHEA_ID":43110,"DIRECTION":"RL","MASTER_ID":43108,"ecocyc":"RXN-12130","metacyc":"RXN-12130","compounds":"2 [Fe(II)cytochrome c] + 2 H(+) + nitrous oxide => 2 [Fe(III)cytochrome c] + H2O + N2"}
{"X":44745,"RHEA_ID":53104,"compounds":"4-hydroxyestrone + S-adenosyl-L-methionine = 4-methoxyestrone + H(+) + S-adenosyl-L-homocysteine"}
{"X":44746,"RHEA_ID":43113,"compounds":"(R)-mandelate + NAD(+) => H(+) + NADH + phenylglyoxylate"}
{"X":44747,"RHEA_ID":43114,"compounds":"H(+) + NADH + phenylglyoxylate => (R)-mandelate + NAD(+)"}
{"X":44748,"RHEA_ID":53107,"compounds":"4-hydroxyestrone + S-adenosyl-L-methionine <=> 4-methoxyestrone + H(+) + S-adenosyl-L-homocysteine"}
{"X":44749,"RHEA_ID":53108,"compounds":"2-hydroxyestrone + S-adenosyl-L-methionine = 2-hydroxy-3-methoxy-estrone + H(+) + S-adenosyl-L-homocysteine"}
{"X":44750,"RHEA_ID":43117,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + N-octanoylsphinganine + O2 => 2 [Fe(III)-cytochrome b5] + H2O + N-octanoyl-4-hydroxysphinganine"}
{"X":44751,"RHEA_ID":43118,"compounds":"2 [Fe(III)-cytochrome b5] + H2O + N-octanoyl-4-hydroxysphinganine => 2 [Fe(II)-cytochrome b5] + 2 H(+) + N-octanoylsphinganine + O2"}
{"X":44752,"RHEA_ID":53111,"compounds":"2-hydroxyestrone + S-adenosyl-L-methionine <=> 2-hydroxy-3-methoxy-estrone + H(+) + S-adenosyl-L-homocysteine"}
{"X":44753,"RHEA_ID":43120,"DIRECTION":"UN","MASTER_ID":43120,"ec":"1.14.11.48","compounds":"2-oxoglutarate + O2 + xanthine = CO2 + succinate + urate"}
{"X":44754,"RHEA_ID":53113,"compounds":"3alpha-hydroxy-5alpha-androstane 17-O-(beta-D-glucuronate) + NADP(+) => 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + NADPH"}
{"X":44755,"RHEA_ID":43122,"compounds":"CO2 + succinate + urate => 2-oxoglutarate + O2 + xanthine"}
{"X":44756,"RHEA_ID":56450,"compounds":"(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O"}
{"X":44757,"RHEA_ID":43124,"DIRECTION":"UN","MASTER_ID":43124,"ec":"2.1.1.213","compounds":"guanosine(10) in tRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(2)-dimethylguanosine(10) in tRNA + 2 S-adenosyl-L-homocysteine"}
{"X":44758,"RHEA_ID":43125,"DIRECTION":"LR","MASTER_ID":43124,"metacyc":"RXN-12373","compounds":"guanosine(10) in tRNA + 2 S-adenosyl-L-methionine => 2 H(+) + N(2)-dimethylguanosine(10) in tRNA + 2 S-adenosyl-L-homocysteine"}
{"X":44759,"RHEA_ID":43126,"compounds":"2 H(+) + N(2)-dimethylguanosine(10) in tRNA + 2 S-adenosyl-L-homocysteine => guanosine(10) in tRNA + 2 S-adenosyl-L-methionine"}
{"X":44760,"RHEA_ID":43127,"compounds":"guanosine(10) in tRNA + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(2)-dimethylguanosine(10) in tRNA + 2 S-adenosyl-L-homocysteine"}
{"X":44761,"RHEA_ID":43128,"DIRECTION":"UN","MASTER_ID":43128,"ec":"2.1.1.214","compounds":"guanosine(10) in tRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-homocysteine"}
{"X":44762,"RHEA_ID":53121,"compounds":"(3beta,5alpha,17beta)-3-hydroxyandrostan-17-yl sulfate + NADP(+) => 5alpha-dihydrotestosterone sulfate + H(+) + NADPH"}
{"X":44763,"RHEA_ID":43130,"compounds":"H(+) + N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-homocysteine => guanosine(10) in tRNA + S-adenosyl-L-methionine"}
{"X":44764,"RHEA_ID":53123,"compounds":"(3beta,5alpha,17beta)-3-hydroxyandrostan-17-yl sulfate + NADP(+) <=> 5alpha-dihydrotestosterone sulfate + H(+) + NADPH"}
{"X":44765,"RHEA_ID":43132,"compounds":"N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-methionine = H(+) + N(2)-dimethylguanosine(10) in tRNA + S-adenosyl-L-homocysteine"}
{"X":44766,"RHEA_ID":43133,"DIRECTION":"LR","MASTER_ID":43132,"metacyc":"RXN-12372","compounds":"N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-methionine => H(+) + N(2)-dimethylguanosine(10) in tRNA + S-adenosyl-L-homocysteine"}
{"X":44767,"RHEA_ID":43134,"compounds":"H(+) + N(2)-dimethylguanosine(10) in tRNA + S-adenosyl-L-homocysteine => N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-methionine"}
{"X":44768,"RHEA_ID":46436,"compounds":"(25R)-3beta,4beta-dihydroxycholest-5-en-26-al + H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta,4beta-dihydroxycholest-5-en-26-oate + H2O + 2 oxidized [adrenodoxin]"}
{"X":44769,"RHEA_ID":43136,"DIRECTION":"UN","MASTER_ID":43136,"ec":"2.1.1.215","compounds":"guanosine(26)/guanosine(27) in tRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(2)-dimethylguanosine(26)/N(2)-dimethylguanosine(27) in tRNA + 4 S-adenosyl-L-homocysteine"}
{"X":44770,"RHEA_ID":53129,"DIRECTION":"LR","MASTER_ID":53128,"metacyc":"RXN-8028","compounds":"delta-carotene => epsilon-carotene"}
{"X":44771,"RHEA_ID":43138,"compounds":"4 H(+) + N(2)-dimethylguanosine(26)/N(2)-dimethylguanosine(27) in tRNA + 4 S-adenosyl-L-homocysteine => guanosine(26)/guanosine(27) in tRNA + 4 S-adenosyl-L-methionine"}
{"X":44772,"RHEA_ID":43139,"compounds":"guanosine(26)/guanosine(27) in tRNA + 4 S-adenosyl-L-methionine <=> 4 H(+) + N(2)-dimethylguanosine(26)/N(2)-dimethylguanosine(27) in tRNA + 4 S-adenosyl-L-homocysteine"}
{"X":44773,"RHEA_ID":43140,"DIRECTION":"UN","MASTER_ID":43140,"ec":"2.1.1.216","compounds":"guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine"}
{"X":44774,"RHEA_ID":53133,"compounds":"A + a 3-oxo-Delta(4)-steroid => a 3-oxo-Delta(1,4)-steroid + AH2"}
{"X":44775,"RHEA_ID":43142,"compounds":"2 H(+) + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine => guanosine(26) in tRNA + 2 S-adenosyl-L-methionine"}
{"X":44776,"RHEA_ID":53135,"compounds":"A + a 3-oxo-Delta(4)-steroid <=> a 3-oxo-Delta(1,4)-steroid + AH2"}
{"X":44777,"RHEA_ID":43144,"DIRECTION":"UN","MASTER_ID":43144,"ec":"2.1.1.217","compounds":"adenosine(22) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(22) in tRNA + S-adenosyl-L-homocysteine"}
{"X":44778,"RHEA_ID":53137,"compounds":"(3beta,5alpha,17beta)-3-hydroxy-androstan-17-yl sulfate + NADP(+) => 5alpha-dihydrotestosterone sulfate + H(+) + NADPH"}
{"X":44779,"RHEA_ID":43146,"compounds":"H(+) + N(1)-methyladenosine(22) in tRNA + S-adenosyl-L-homocysteine => adenosine(22) in tRNA + S-adenosyl-L-methionine"}
{"X":44780,"RHEA_ID":53139,"compounds":"(3beta,5alpha,17beta)-3-hydroxy-androstan-17-yl sulfate + NADP(+) <=> 5alpha-dihydrotestosterone sulfate + H(+) + NADPH"}
{"X":44781,"RHEA_ID":43148,"DIRECTION":"UN","MASTER_ID":43148,"ec":"2.1.1.218","compounds":"adenosine(9) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(9) in tRNA + S-adenosyl-L-homocysteine"}
{"X":44782,"RHEA_ID":53141,"compounds":"N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N-(8,9-epoxy-5Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]"}
{"X":44783,"RHEA_ID":43150,"compounds":"H(+) + N(1)-methyladenosine(9) in tRNA + S-adenosyl-L-homocysteine => adenosine(9) in tRNA + S-adenosyl-L-methionine"}
{"X":44784,"RHEA_ID":53143,"compounds":"N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N-(8,9-epoxy-5Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]"}
{"X":44785,"RHEA_ID":43152,"DIRECTION":"UN","MASTER_ID":43152,"ec":"2.1.1.220","compounds":"adenosine(58) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine"}
{"X":44786,"RHEA_ID":53145,"compounds":"N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N-(11,12-epoxy-5Z,8Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]"}
{"X":44787,"RHEA_ID":43154,"compounds":"H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine => adenosine(58) in tRNA + S-adenosyl-L-methionine"}
{"X":44788,"RHEA_ID":53147,"compounds":"N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N-(11,12-epoxy-5Z,8Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]"}
{"X":44789,"RHEA_ID":43156,"DIRECTION":"UN","MASTER_ID":43156,"ec":"2.1.1.221","compounds":"guanosine(9) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine"}
{"X":44790,"RHEA_ID":53149,"compounds":"N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N-(14,15-epoxy-5Z,8Z,11Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]"}
{"X":44791,"RHEA_ID":43158,"compounds":"H(+) + N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine => guanosine(9) in tRNA + S-adenosyl-L-methionine"}
{"X":44792,"RHEA_ID":53151,"compounds":"N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N-(14,15-epoxy-5Z,8Z,11Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]"}
{"X":44793,"RHEA_ID":43160,"DIRECTION":"UN","MASTER_ID":43160,"ec":"2.1.1.223","compounds":"adenosine(37) in tRNA1(Val) + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(37) in tRNA1(Val) + S-adenosyl-L-homocysteine"}
{"X":44794,"RHEA_ID":43161,"DIRECTION":"LR","MASTER_ID":43160,"ecocyc":"RXN-12480","metacyc":"RXN-12480","compounds":"adenosine(37) in tRNA1(Val) + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine(37) in tRNA1(Val) + S-adenosyl-L-homocysteine"}
{"X":44795,"RHEA_ID":43162,"compounds":"H(+) + N(6)-methyladenosine(37) in tRNA1(Val) + S-adenosyl-L-homocysteine => adenosine(37) in tRNA1(Val) + S-adenosyl-L-methionine"}
{"X":44796,"RHEA_ID":53155,"compounds":"N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N-(20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]"}
{"X":44797,"RHEA_ID":43164,"DIRECTION":"UN","MASTER_ID":43164,"ec":"2.4.2.48","compounds":"7-cyano-7-deazaguanine + guanosine(15) in tRNA = 7-cyano-7-carbaguanosine(15) in tRNA + guanine"}
{"X":44798,"RHEA_ID":43165,"DIRECTION":"LR","MASTER_ID":43164,"metacyc":"RXN-12144","compounds":"7-cyano-7-deazaguanine + guanosine(15) in tRNA => 7-cyano-7-carbaguanosine(15) in tRNA + guanine"}
{"X":44799,"RHEA_ID":43166,"compounds":"7-cyano-7-carbaguanosine(15) in tRNA + guanine => 7-cyano-7-deazaguanine + guanosine(15) in tRNA"}
{"X":44800,"RHEA_ID":53159,"compounds":"N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N-(5,6-epoxy-8Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]"}
{"X":44801,"RHEA_ID":43168,"DIRECTION":"UN","MASTER_ID":43168,"ec":"3.5.4.33","compounds":"adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA + NH4(+)"}
{"X":44802,"RHEA_ID":43169,"compounds":"adenosine(34) in tRNA + H(+) + H2O => inosine(34) in tRNA + NH4(+)"}
{"X":44803,"RHEA_ID":53162,"compounds":"an N-acylethanolamine + H(+) + sn-glycerol 3-phosphate => H2O + N-acyl-sn-glycero-3-phosphoethanolamine"}
{"X":44804,"RHEA_ID":53163,"compounds":"H2O + N-acyl-sn-glycero-3-phosphoethanolamine <=> an N-acylethanolamine + H(+) + sn-glycerol 3-phosphate"}
{"X":44805,"RHEA_ID":43172,"DIRECTION":"UN","MASTER_ID":43172,"ec":"2.1.1.309","compounds":"guanosine(1575) in yeast 18S rRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(1575) in yeast 18S rRNA + S-adenosyl-L-homocysteine"}
{"X":44806,"RHEA_ID":43173,"compounds":"guanosine(1575) in yeast 18S rRNA + S-adenosyl-L-methionine => N(7)-methylguanosine(1575) in yeast 18S rRNA + S-adenosyl-L-homocysteine"}
{"X":44807,"RHEA_ID":53166,"compounds":"a 1-acyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+) => H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine"}
{"X":44808,"RHEA_ID":43175,"DIRECTION":"BI","MASTER_ID":43172,"metacyc":"RXN-15842","compounds":"guanosine(1575) in yeast 18S rRNA + S-adenosyl-L-methionine <=> N(7)-methylguanosine(1575) in yeast 18S rRNA + S-adenosyl-L-homocysteine"}
{"X":44809,"RHEA_ID":43176,"DIRECTION":"UN","MASTER_ID":43176,"ec":"2.1.1.310","compounds":"cytidine(2870) in 25S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(2870) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":44810,"RHEA_ID":53169,"compounds":"H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}
{"X":44811,"RHEA_ID":53170,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":44812,"RHEA_ID":53171,"compounds":"H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}
{"X":44813,"RHEA_ID":43180,"DIRECTION":"UN","MASTER_ID":43180,"ec":"2.1.1.311","compounds":"cytidine(2278) in 25S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(2278) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":44814,"RHEA_ID":43181,"DIRECTION":"LR","MASTER_ID":43180,"metacyc":"RXN-15844","compounds":"cytidine(2278) in 25S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(2278) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":44815,"RHEA_ID":53174,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphate + ethanolamine + H(+) => 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O"}
{"X":44816,"RHEA_ID":53175,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphate + ethanolamine + H(+)"}
{"X":44817,"RHEA_ID":43184,"DIRECTION":"UN","MASTER_ID":43184,"ec":"2.1.1.312","compounds":"S-adenosyl-L-methionine + uridine(2843) in 25S rRNA = H(+) + N(3)-methyluridine(2843) in 25S rRNA + S-adenosyl-L-homocysteine"}
{"X":44818,"RHEA_ID":53177,"compounds":"H2O + N-acyl-1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)"}
{"X":44819,"RHEA_ID":53178,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an N-acylethanolamine + H(+) => H2O + N-acyl-1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine"}
{"X":44820,"RHEA_ID":43187,"DIRECTION":"BI","MASTER_ID":43184,"metacyc":"RXN-15845","compounds":"S-adenosyl-L-methionine + uridine(2843) in 25S rRNA <=> H(+) + N(3)-methyluridine(2843) in 25S rRNA + S-adenosyl-L-homocysteine"}
{"X":44821,"RHEA_ID":43188,"DIRECTION":"UN","MASTER_ID":43188,"ec":"2.1.1.313","compounds":"S-adenosyl-L-methionine + uridine(2634) in 25S rRNA = H(+) + N(3)-methyluridine(2634) in 25S rRNA + S-adenosyl-L-homocysteine"}
{"X":44822,"RHEA_ID":53181,"compounds":"D-erythrose => D-erythrulose"}
{"X":44823,"RHEA_ID":53182,"compounds":"D-erythrulose => D-erythrose"}
{"X":44824,"RHEA_ID":43191,"compounds":"S-adenosyl-L-methionine + uridine(2634) in 25S rRNA <=> H(+) + N(3)-methyluridine(2634) in 25S rRNA + S-adenosyl-L-homocysteine"}
{"X":44825,"RHEA_ID":43192,"DIRECTION":"UN","MASTER_ID":43192,"ec":"2.1.1.225","compounds":"cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + H(+) + S-adenosyl-L-homocysteine"}
{"X":44826,"RHEA_ID":56520,"DIRECTION":"UN","MASTER_ID":56520,"ec":"1.3.98.6","compounds":"Fe-coproporphyrin III + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + 2 CO2 + heme b + 2 L-methionine"}
{"X":44827,"RHEA_ID":53186,"compounds":"1-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H2O"}
{"X":44828,"RHEA_ID":43195,"compounds":"cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + H(+) + S-adenosyl-L-homocysteine"}
{"X":44829,"RHEA_ID":43196,"DIRECTION":"UN","MASTER_ID":43196,"ec":"2.1.1.225","compounds":"adenosine(4) in tRNA(His) + S-adenosyl-L-methionine = 2'-O-methyladenosine(4) in tRNA(His) + H(+) + S-adenosyl-L-homocysteine"}
{"X":44830,"RHEA_ID":53189,"compounds":"1-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-9Z-octadecenoyl)-ethanolamine + H2O => 1-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine"}
{"X":44831,"RHEA_ID":53190,"compounds":"1-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine => 1-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-9Z-octadecenoyl)-ethanolamine + H2O"}
{"X":44832,"RHEA_ID":43199,"compounds":"adenosine(4) in tRNA(His) + S-adenosyl-L-methionine <=> 2'-O-methyladenosine(4) in tRNA(His) + H(+) + S-adenosyl-L-homocysteine"}
{"X":44833,"RHEA_ID":43200,"DIRECTION":"UN","MASTER_ID":43200,"ec":"2.1.1.226","compounds":"cytidine(1920) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1920) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":44834,"RHEA_ID":53193,"compounds":"1-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + H2O => 1-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine"}
{"X":44835,"RHEA_ID":43202,"compounds":"2'-O-methylcytidine(1920) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1920) in 23S rRNA + S-adenosyl-L-methionine"}
{"X":44836,"RHEA_ID":43203,"compounds":"cytidine(1920) in 23S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(1920) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":44837,"RHEA_ID":43204,"DIRECTION":"UN","MASTER_ID":43204,"ec":"2.1.1.227","compounds":"cytidine(1409) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1409) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":44838,"RHEA_ID":53197,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 16alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":44839,"RHEA_ID":53198,"compounds":"16alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone"}
{"X":44840,"RHEA_ID":43207,"compounds":"cytidine(1409) in 16S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(1409) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":44841,"RHEA_ID":43208,"DIRECTION":"UN","MASTER_ID":43208,"ec":"2.1.1.229","compounds":"carboxymethyluridine(34) in tRNA + S-adenosyl-L-methionine = 5-(2-methoxy-2-oxoethyl)uridine(34) in tRNA + S-adenosyl-L-homocysteine"}
{"X":44842,"RHEA_ID":53201,"compounds":"17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase] => 17beta,19-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":44843,"RHEA_ID":43210,"compounds":"5-(2-methoxy-2-oxoethyl)uridine(34) in tRNA + S-adenosyl-L-homocysteine => carboxymethyluridine(34) in tRNA + S-adenosyl-L-methionine"}
{"X":44844,"RHEA_ID":43211,"compounds":"carboxymethyluridine(34) in tRNA + S-adenosyl-L-methionine <=> 5-(2-methoxy-2-oxoethyl)uridine(34) in tRNA + S-adenosyl-L-homocysteine"}
{"X":44845,"RHEA_ID":43212,"DIRECTION":"UN","MASTER_ID":43212,"ec":"2.1.1.230","compounds":"adenosine(1067) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methyladenosine(1067) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":44846,"RHEA_ID":53205,"compounds":"17beta,19-dihydroxy-3-oxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase] => 17beta-hydroxy-3,19-dioxo-5alpha-androstanone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":44847,"RHEA_ID":53206,"compounds":"17beta-hydroxy-3,19-dioxo-5alpha-androstanone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 17beta,19-dihydroxy-3-oxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":44848,"RHEA_ID":43215,"compounds":"adenosine(1067) in 23S rRNA + S-adenosyl-L-methionine <=> 2'-O-methyladenosine(1067) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":44849,"RHEA_ID":43216,"compounds":"(24S)-hydroxycholesterol + 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine = (24S)-24-hydroxycholesterol ester + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":44850,"RHEA_ID":53209,"DIRECTION":"LR","MASTER_ID":53208,"metacyc":"RXN-4501","compounds":"daidzein + O2 + reduced [NADPH--hemoprotein reductase] => 2'-hydroxydaidzein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":44851,"RHEA_ID":53210,"compounds":"2'-hydroxydaidzein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => daidzein + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":44852,"RHEA_ID":43219,"compounds":"(24S)-hydroxycholesterol + 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine <=> (24S)-24-hydroxycholesterol ester + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":44853,"RHEA_ID":43220,"DIRECTION":"UN","MASTER_ID":43220,"ec":"2.1.1.242","compounds":"guanosine(1516) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(1516) in 16S rRNA + S-adenosyl-L-homocysteine"}
{"X":44854,"RHEA_ID":46526,"compounds":"(5Z,11Z,14Z)-eicosatrienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => (11Z,14Z)-eicosadienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}
{"X":44855,"RHEA_ID":43222,"compounds":"H(+) + N(2)-methylguanosine(1516) in 16S rRNA + S-adenosyl-L-homocysteine => guanosine(1516) in 16S rRNA + S-adenosyl-L-methionine"}
{"X":44856,"RHEA_ID":43223,"compounds":"guanosine(1516) in 16S rRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(1516) in 16S rRNA + S-adenosyl-L-homocysteine"}
{"X":44857,"RHEA_ID":43224,"compounds":"(24S)-hydroxycholesterol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine = (24S)-hydroxycholesterol 3-linoleoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":44858,"RHEA_ID":53217,"compounds":"17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] => 16alpha,17alpha-dihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":44859,"RHEA_ID":43226,"compounds":"(24S)-hydroxycholesterol 3-linoleoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine => (24S)-hydroxycholesterol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine"}
{"X":44860,"RHEA_ID":43227,"compounds":"(24S)-hydroxycholesterol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine <=> (24S)-hydroxycholesterol 3-linoleoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":44861,"RHEA_ID":43228,"compounds":"L-glutamine(104)-[histone H2A] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutamine(104)-[histone H2A] + S-adenosyl-L-homocysteine"}
{"X":44862,"RHEA_ID":53221,"compounds":"16alpha,17alpha-dihydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] => 6beta,16alpha,17alpha-trihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":44863,"RHEA_ID":53222,"compounds":"6beta,16alpha,17alpha-trihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 16alpha,17alpha-dihydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":44864,"RHEA_ID":43231,"compounds":"L-glutamine(104)-[histone H2A] + S-adenosyl-L-methionine <=> H(+) + N(5)-methyl-L-glutamine(104)-[histone H2A] + S-adenosyl-L-homocysteine"}
{"X":44865,"RHEA_ID":43232,"DIRECTION":"UN","MASTER_ID":43232,"ec":"3.5.2.20","compounds":"H2O + isatin = H(+) + isatinate"}
{"X":44866,"RHEA_ID":53225,"compounds":"16alpha,17alpha-dihydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase] => 3beta,16alpha-dihydroxy-androst-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":44867,"RHEA_ID":53226,"compounds":"3beta,16alpha-dihydroxy-androst-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 16alpha,17alpha-dihydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":44868,"RHEA_ID":53227,"compounds":"16alpha,17alpha-dihydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta,16alpha-dihydroxy-androst-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":44869,"RHEA_ID":43236,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O = 1,2-dihexadecanoyl-sn-glycerol + phosphate"}
{"X":44870,"RHEA_ID":53229,"compounds":"androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] => 16alpha-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":44871,"RHEA_ID":53230,"compounds":"16alpha-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":44872,"RHEA_ID":43239,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O <=> 1,2-dihexadecanoyl-sn-glycerol + phosphate"}
{"X":44873,"RHEA_ID":43240,"compounds":"1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O = 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate"}
{"X":44874,"RHEA_ID":43241,"compounds":"1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate"}
{"X":44875,"RHEA_ID":53234,"compounds":"(24S)-25-epoxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesta-5,24-dien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":44876,"RHEA_ID":43243,"compounds":"1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O <=> 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate"}
{"X":44877,"RHEA_ID":43244,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + phosphate"}
{"X":44878,"RHEA_ID":53237,"compounds":"cholesta-5,24-dien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => cholesta-5,24Z-dien-3beta,27-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":44879,"RHEA_ID":53238,"compounds":"cholesta-5,24Z-dien-3beta,27-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesta-5,24-dien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":44880,"RHEA_ID":43247,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 1,2-di-(9Z-octadecenoyl)-sn-glycerol + phosphate"}
{"X":44881,"RHEA_ID":43248,"compounds":"1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O = 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + phosphate"}
{"X":44882,"RHEA_ID":46554,"compounds":"2 [Fe(III)-cytochrome b5] + a (9Z)-octadec-9-en-12-ynoyl-containing glycerolipid + 2 H2O => 2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2"}
{"X":44883,"RHEA_ID":43250,"compounds":"1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + phosphate => 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O"}
{"X":44884,"RHEA_ID":43251,"compounds":"1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O <=> 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + phosphate"}
{"X":44885,"RHEA_ID":43252,"compounds":"1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O = 1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate"}
{"X":44886,"RHEA_ID":49938,"compounds":"5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":44887,"RHEA_ID":43254,"compounds":"1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate => 1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O"}
{"X":44888,"RHEA_ID":43255,"compounds":"1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O <=> 1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate"}
{"X":44889,"RHEA_ID":43256,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate"}
{"X":44890,"RHEA_ID":46562,"compounds":"2 [Fe(III)-cytochrome b5] + ergosta-5,7,24(28)-trien-3beta-ol + 2 H2O => 2 [Fe(II)-cytochrome b5] + episterol + 2 H(+) + O2"}
{"X":44891,"RHEA_ID":53250,"compounds":"3beta-hydroxycholest-5-en-7-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesta-5,7-dien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":44892,"RHEA_ID":43259,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate"}
{"X":44893,"RHEA_ID":43260,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate"}
{"X":44894,"RHEA_ID":53253,"compounds":"5alpha-cholest-7-en-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => 5alpha-cholestan-7-oxo-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":44895,"RHEA_ID":53254,"compounds":"5alpha-cholestan-7-oxo-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 5alpha-cholest-7-en-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":44896,"RHEA_ID":43263,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate"}
{"X":44897,"RHEA_ID":43264,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + eicosanoyl-CoA = 1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":44898,"RHEA_ID":43265,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + eicosanoyl-CoA => 1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":44899,"RHEA_ID":53258,"compounds":"7alpha,8alpha-epoxy-5alpha-cholestan-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 5alpha-cholest-7-en-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":44900,"RHEA_ID":43267,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + eicosanoyl-CoA <=> 1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine + CoA"}
{"X":44901,"RHEA_ID":43268,"compounds":"ganglioside GM3 + UDP-N-acetyl-alpha-D-galactosamine = ganglioside GM2 + H(+) + UDP"}
{"X":44902,"RHEA_ID":53261,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 1beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":44903,"RHEA_ID":43270,"compounds":"ganglioside GM2 + H(+) + UDP => ganglioside GM3 + UDP-N-acetyl-alpha-D-galactosamine"}
{"X":44904,"RHEA_ID":53263,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 1beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":44905,"RHEA_ID":43272,"compounds":"ganglioside GD3 + UDP-N-acetyl-alpha-D-galactosamine = ganglioside GD2 + H(+) + UDP"}
{"X":44906,"RHEA_ID":46578,"compounds":"2 H2O + NADP(+) + stigmasterol => (24R)-ethylcholest-5-en-3beta-ol + H(+) + NADPH + O2"}
{"X":44907,"RHEA_ID":43274,"compounds":"ganglioside GD2 + H(+) + UDP => ganglioside GD3 + UDP-N-acetyl-alpha-D-galactosamine"}
{"X":44908,"RHEA_ID":53267,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 2beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":44909,"RHEA_ID":43276,"compounds":"ganglioside GD1a + UDP-N-acetyl-alpha-D-galactosamine = H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->3)]-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP"}
{"X":44910,"RHEA_ID":53269,"compounds":"L-ribulose => L-xylulose"}
{"X":44911,"RHEA_ID":43278,"compounds":"H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->3)]-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP => ganglioside GD1a + UDP-N-acetyl-alpha-D-galactosamine"}
{"X":44912,"RHEA_ID":53271,"compounds":"L-ribulose <=> L-xylulose"}
{"X":44913,"RHEA_ID":43280,"compounds":"1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate"}
{"X":44914,"RHEA_ID":43281,"compounds":"1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate"}
{"X":44915,"RHEA_ID":43282,"compounds":"1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O"}
{"X":44916,"RHEA_ID":53275,"compounds":"5-dehydro-L-gluconate <=> keto-D-tagaturonate"}
{"X":44917,"RHEA_ID":43284,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate"}
{"X":44918,"RHEA_ID":53277,"compounds":"17beta-hydroxy-3,19-dioxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase] => 17beta-hydroxy-3-oxo-19-nor-5alpha-androst-1-ene + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":44919,"RHEA_ID":43286,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O"}
{"X":44920,"RHEA_ID":43287,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate"}
{"X":44921,"RHEA_ID":43288,"compounds":"1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + phosphate"}
{"X":44922,"RHEA_ID":53281,"compounds":"D-threose => D-erythrulose"}
{"X":44923,"RHEA_ID":43290,"compounds":"1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + phosphate => 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O"}
{"X":44924,"RHEA_ID":53283,"compounds":"D-threose <=> D-erythrulose"}
{"X":44925,"RHEA_ID":43292,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate"}
{"X":44926,"RHEA_ID":53285,"DIRECTION":"LR","MASTER_ID":53284,"metacyc":"RXN-14358","compounds":"NAD(+) + scyllo-inosose => 3-dehydro-scyllo-inosose + H(+) + NADH"}
{"X":44927,"RHEA_ID":43294,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O"}
{"X":44928,"RHEA_ID":53287,"compounds":"NAD(+) + scyllo-inosose <=> 3-dehydro-scyllo-inosose + H(+) + NADH"}
{"X":44929,"RHEA_ID":43296,"compounds":"1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate"}
{"X":44930,"RHEA_ID":53289,"DIRECTION":"LR","MASTER_ID":53288,"metacyc":"RXN-14359","compounds":"3-dehydro-scyllo-inosose + H2O => 5-dehydro-L-gluconate + H(+)"}
{"X":44931,"RHEA_ID":43298,"compounds":"1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O"}
{"X":44932,"RHEA_ID":53291,"compounds":"3-dehydro-scyllo-inosose + H2O <=> 5-dehydro-L-gluconate + H(+)"}
{"X":44933,"RHEA_ID":43300,"compounds":"alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP-N-acetyl-alpha-D-galactosamine = H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-glycoloylneuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP"}
{"X":44934,"RHEA_ID":43301,"compounds":"alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP-N-acetyl-alpha-D-galactosamine => H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-glycoloylneuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP"}
{"X":44935,"RHEA_ID":43302,"compounds":"H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-glycoloylneuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP => alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP-N-acetyl-alpha-D-galactosamine"}
{"X":44936,"RHEA_ID":43303,"compounds":"alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP-N-acetyl-alpha-D-galactosamine <=> H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-glycoloylneuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP"}
{"X":44937,"RHEA_ID":43304,"compounds":"3'-phosphoadenylyl sulfate + a D-galactosylceramide = 1-(3-O-sulfo-beta-D-galactosyl)-ceramide + adenosine 3',5'-bisphosphate + H(+)"}
{"X":44938,"RHEA_ID":53297,"compounds":"(2E)-decenoyl-CoA + NADP(+) => (2E,4E)-decadienoyl-CoA + H(+) + NADPH"}
{"X":44939,"RHEA_ID":43306,"compounds":"1-(3-O-sulfo-beta-D-galactosyl)-ceramide + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + a D-galactosylceramide"}
{"X":44940,"RHEA_ID":53299,"compounds":"(2E)-decenoyl-CoA + NADP(+) <=> (2E,4E)-decadienoyl-CoA + H(+) + NADPH"}
{"X":44941,"RHEA_ID":43308,"compounds":"1-hexadecanoyl-sn-glycerol + ATP = 1-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":44942,"RHEA_ID":53301,"compounds":"D-5-[2-(methylsulfanyl)ethyl]hydantoin + H2O => H(+) + N-carbamoyl-D-methionine"}
{"X":44943,"RHEA_ID":43310,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+) => 1-hexadecanoyl-sn-glycerol + ATP"}
{"X":44944,"RHEA_ID":53303,"compounds":"D-5-[2-(methylsulfanyl)ethyl]hydantoin + H2O <=> H(+) + N-carbamoyl-D-methionine"}
{"X":44945,"RHEA_ID":43312,"compounds":"ATP + N-(hexanoyl)sphing-4-enine = ADP + H(+) + N-hexanoylsphing-4-enine 1-phosphate"}
{"X":44946,"RHEA_ID":53305,"compounds":"AH2 + 2 ATP + 2 cob(II)alamin => A + 2 adenosylcob(III)alamin + 2 H(+) + 2 triphosphate"}
{"X":44947,"RHEA_ID":53306,"compounds":"A + 2 adenosylcob(III)alamin + 2 H(+) + 2 triphosphate => AH2 + 2 ATP + 2 cob(II)alamin"}
{"X":44948,"RHEA_ID":43315,"compounds":"ATP + N-(hexanoyl)sphing-4-enine <=> ADP + H(+) + N-hexanoylsphing-4-enine 1-phosphate"}
{"X":44949,"RHEA_ID":43316,"compounds":"2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + ATP = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":44950,"RHEA_ID":53309,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":44951,"RHEA_ID":43318,"compounds":"2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + ATP"}
{"X":44952,"RHEA_ID":43319,"compounds":"2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + ATP <=> 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":44953,"RHEA_ID":43320,"compounds":"1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + sphingomyelin = a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine"}
{"X":44954,"RHEA_ID":43321,"compounds":"1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + sphingomyelin => a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine"}
{"X":44955,"RHEA_ID":46617,"compounds":"calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (23S)-23,25-dihydroxycalciol + H2O + 2 oxidized [adrenodoxin]"}
{"X":44956,"RHEA_ID":53315,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 16(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":44957,"RHEA_ID":43324,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + sphingomyelin"}
{"X":44958,"RHEA_ID":43325,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine => 1,2-dihexadecanoyl-sn-glycerol + sphingomyelin"}
{"X":44959,"RHEA_ID":53318,"compounds":"alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,poly-cis-undecaprenol + GDP + H(+) => GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol"}
{"X":44960,"RHEA_ID":60062,"compounds":"alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose"}
{"X":44961,"RHEA_ID":43328,"compounds":"1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":44962,"RHEA_ID":43329,"compounds":"1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":44963,"RHEA_ID":43330,"compounds":"1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP"}
{"X":44964,"RHEA_ID":43331,"compounds":"1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":44965,"RHEA_ID":43332,"DIRECTION":"UN","MASTER_ID":43332,"ec":"2.1.1.192","compounds":"adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine"}
{"X":44966,"RHEA_ID":53325,"compounds":"2-glyceryl-prostaglandin H2 => 2-glyceryl-prostaglandin E2"}
{"X":44967,"RHEA_ID":43334,"compounds":"2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine => adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine"}
{"X":44968,"RHEA_ID":53327,"compounds":"2-glyceryl-prostaglandin H2 <=> 2-glyceryl-prostaglandin E2"}
{"X":44969,"RHEA_ID":43336,"DIRECTION":"UN","MASTER_ID":43336,"ec":"7.2.4.1","compounds":"H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + n Na(+)(in) = CO2 + N(6)-biotinyl-L-lysyl-[protein] + n Na(+)(out)"}
{"X":44970,"RHEA_ID":43337,"DIRECTION":"LR","MASTER_ID":43336,"metacyc":"RXN-9777","compounds":"H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + n Na(+)(in) => CO2 + N(6)-biotinyl-L-lysyl-[protein] + n Na(+)(out)"}
{"X":44971,"RHEA_ID":43338,"compounds":"CO2 + N(6)-biotinyl-L-lysyl-[protein] + n Na(+)(out) => H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + n Na(+)(in)"}
{"X":44972,"RHEA_ID":56665,"DIRECTION":"LR","MASTER_ID":56664,"metacyc":"BAI3OXO-OXRED-RXN","compounds":"7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + NAD(+) => 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH"}
{"X":44973,"RHEA_ID":43340,"compounds":"[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]"}
{"X":44974,"RHEA_ID":43341,"DIRECTION":"LR","MASTER_ID":43340,"ecocyc":"RXN-9788","metacyc":"RXN-9788","compounds":"[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] => [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]"}
{"X":44975,"RHEA_ID":43342,"compounds":"[sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase] => [sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase]"}
{"X":44976,"RHEA_ID":56669,"DIRECTION":"LR","MASTER_ID":56668,"metacyc":"RXN-17416","compounds":"7beta-hydroxy-3-oxochol-24-oyl-CoA + NAD(+) => 7beta-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH"}
{"X":44977,"RHEA_ID":43344,"DIRECTION":"UN","MASTER_ID":43344,"ec":"2.7.7.73","compounds":"[sulfur-carrier protein ThiS]-C-terminal Gly-Gly + ATP + H(+) = [sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + diphosphate"}
{"X":44978,"RHEA_ID":53337,"compounds":"5,6-dihydrouridine(20) in tRNA + NADP(+) => H(+) + NADPH + uridine(20) in tRNA"}
{"X":44979,"RHEA_ID":43346,"compounds":"[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + diphosphate => [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + ATP + H(+)"}
{"X":44980,"RHEA_ID":53339,"compounds":"5,6-dihydrouridine(20) in tRNA + NADP(+) <=> H(+) + NADPH + uridine(20) in tRNA"}
{"X":44981,"RHEA_ID":43348,"compounds":"cholesteryl (9Z-octadecenoate)(in) = cholesteryl (9Z-octadecenoate)(out)"}
{"X":44982,"RHEA_ID":43349,"compounds":"cholesteryl (9Z-octadecenoate)(in) => cholesteryl (9Z-octadecenoate)(out)"}
{"X":44983,"RHEA_ID":43350,"compounds":"cholesteryl (9Z-octadecenoate)(out) => cholesteryl (9Z-octadecenoate)(in)"}
{"X":44984,"RHEA_ID":53343,"compounds":"5,6-dihydrouridine(20) in tRNA + NAD(+) <=> H(+) + NADH + uridine(20) in tRNA"}
{"X":44985,"RHEA_ID":43352,"compounds":"1,2,3-tri-(9Z-octadecenoyl)-glycerol(in) = 1,2,3-tri-(9Z-octadecenoyl)-glycerol(out)"}
{"X":44986,"RHEA_ID":43353,"compounds":"1,2,3-tri-(9Z-octadecenoyl)-glycerol(in) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol(out)"}
{"X":44987,"RHEA_ID":43354,"compounds":"1,2,3-tri-(9Z-octadecenoyl)-glycerol(out) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol(in)"}
{"X":44988,"RHEA_ID":53347,"compounds":"5,6-dihydrouridine(20a) in tRNA + NADP(+) <=> H(+) + NADPH + uridine(20a) in tRNA"}
{"X":44989,"RHEA_ID":53348,"DIRECTION":"UN","MASTER_ID":53348,"ec":"1.3.1.90","compounds":"5,6-dihydrouridine(20a) in tRNA + NAD(+) = H(+) + NADH + uridine(20a) in tRNA"}
{"X":44990,"RHEA_ID":43357,"compounds":"cholesteryl (9Z,12Z)-octadecadienoate(in) => cholesteryl (9Z,12Z)-octadecadienoate(out)"}
{"X":44991,"RHEA_ID":43358,"compounds":"cholesteryl (9Z,12Z)-octadecadienoate(out) => cholesteryl (9Z,12Z)-octadecadienoate(in)"}
{"X":44992,"RHEA_ID":53351,"compounds":"5,6-dihydrouridine(20a) in tRNA + NAD(+) <=> H(+) + NADH + uridine(20a) in tRNA"}
{"X":44993,"RHEA_ID":53352,"DIRECTION":"UN","MASTER_ID":53352,"ec":"1.3.1.90","compounds":"5,6-dihydrouridine(20b) in tRNA + NAD(+) = H(+) + NADH + uridine(20b) in tRNA"}
{"X":44994,"RHEA_ID":53353,"compounds":"5,6-dihydrouridine(20b) in tRNA + NAD(+) => H(+) + NADH + uridine(20b) in tRNA"}
{"X":44995,"RHEA_ID":43362,"compounds":"an N-acyl-beta-D-glucosyl-(1<->1')-sphinganine + H(+) + UDP => an N-acylsphinganine + UDP-alpha-D-glucose"}
{"X":44996,"RHEA_ID":53355,"compounds":"5,6-dihydrouridine(20b) in tRNA + NAD(+) <=> H(+) + NADH + uridine(20b) in tRNA"}
{"X":44997,"RHEA_ID":53356,"DIRECTION":"UN","MASTER_ID":53356,"ec":"1.3.1.90","compounds":"5,6-dihydrouridine(20b) in tRNA + NADP(+) = H(+) + NADPH + uridine(20b) in tRNA"}
{"X":44998,"RHEA_ID":53357,"compounds":"5,6-dihydrouridine(20b) in tRNA + NADP(+) => H(+) + NADPH + uridine(20b) in tRNA"}
{"X":44999,"RHEA_ID":43366,"compounds":"beta-D-glucosyl-L-erythro-N-acylsphing-4-enine + H(+) + UDP => L-erythro-N-acylsphing-4-enine + UDP-alpha-D-glucose"}
{"X":45000,"RHEA_ID":53359,"compounds":"5,6-dihydrouridine(20b) in tRNA + NADP(+) <=> H(+) + NADPH + uridine(20b) in tRNA"}
{"X":45001,"RHEA_ID":43368,"compounds":"dodecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(2-oxotridecyl)pyran-2-one + 3 CO2 + 4 CoA"}
{"X":45002,"RHEA_ID":53361,"compounds":"5,6-dihydrouridine(47) in tRNA + NADP(+) => H(+) + NADPH + uridine(47) in tRNA"}
{"X":45003,"RHEA_ID":43370,"compounds":"4-hydroxy-6-(2-oxotridecyl)pyran-2-one + 3 CO2 + 4 CoA => dodecanoyl-CoA + 3 H(+) + 3 malonyl-CoA"}
{"X":45004,"RHEA_ID":53363,"compounds":"5,6-dihydrouridine(47) in tRNA + NADP(+) <=> H(+) + NADPH + uridine(47) in tRNA"}
{"X":45005,"RHEA_ID":43372,"compounds":"an N-acylsphing-4-enine + dTDP-alpha-D-glucose = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + dTDP + H(+)"}
{"X":45006,"RHEA_ID":43373,"compounds":"an N-acylsphing-4-enine + dTDP-alpha-D-glucose => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + dTDP + H(+)"}
{"X":45007,"RHEA_ID":43374,"compounds":"a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + dTDP + H(+) => an N-acylsphing-4-enine + dTDP-alpha-D-glucose"}
{"X":45008,"RHEA_ID":43375,"compounds":"an N-acylsphing-4-enine + dTDP-alpha-D-glucose <=> a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + dTDP + H(+)"}
{"X":45009,"RHEA_ID":53368,"DIRECTION":"UN","MASTER_ID":53368,"ec":"1.3.1.88","compounds":"5,6-dihydrouridine(17) in tRNA + NADP(+) = H(+) + NADPH + uridine(17) in tRNA"}
{"X":45010,"RHEA_ID":43377,"compounds":"5'-deoxyinosine + phosphate => 5-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine"}
{"X":45011,"RHEA_ID":43378,"compounds":"5-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine => 5'-deoxyinosine + phosphate"}
{"X":45012,"RHEA_ID":53371,"compounds":"5,6-dihydrouridine(17) in tRNA + NADP(+) <=> H(+) + NADPH + uridine(17) in tRNA"}
{"X":45013,"RHEA_ID":53372,"DIRECTION":"UN","MASTER_ID":53372,"ec":"1.3.1.88","compounds":"5,6-dihydrouridine(17) in tRNA + NAD(+) = H(+) + NADH + uridine(17) in tRNA"}
{"X":45014,"RHEA_ID":53373,"compounds":"5,6-dihydrouridine(17) in tRNA + NAD(+) => H(+) + NADH + uridine(17) in tRNA"}
{"X":45015,"RHEA_ID":43382,"compounds":"L-arginyl-[protein] + phosphate => H2O + N(omega)-phospho-L-arginyl-[protein]"}
{"X":45016,"RHEA_ID":53375,"compounds":"5,6-dihydrouridine(17) in tRNA + NAD(+) <=> H(+) + NADH + uridine(17) in tRNA"}
{"X":45017,"RHEA_ID":53376,"DIRECTION":"UN","MASTER_ID":53376,"ec":"1.3.1.88","compounds":"5,6-dihydrouridine(16) in tRNA + NADP(+) = H(+) + NADPH + uridine(16) in tRNA"}
{"X":45018,"RHEA_ID":43385,"compounds":"ATP + L-arginyl-[protein] => ADP + H(+) + N(omega)-phospho-L-arginyl-[protein]"}
{"X":45019,"RHEA_ID":43386,"compounds":"ADP + H(+) + N(omega)-phospho-L-arginyl-[protein] => ATP + L-arginyl-[protein]"}
{"X":45020,"RHEA_ID":53379,"compounds":"5,6-dihydrouridine(16) in tRNA + NADP(+) <=> H(+) + NADPH + uridine(16) in tRNA"}
{"X":45021,"RHEA_ID":53380,"DIRECTION":"UN","MASTER_ID":53380,"ec":"1.3.1.88","compounds":"5,6-dihydrouridine(16) in tRNA + NAD(+) = H(+) + NADH + uridine(16) in tRNA"}
{"X":45022,"RHEA_ID":53381,"compounds":"5,6-dihydrouridine(16) in tRNA + NAD(+) => H(+) + NADH + uridine(16) in tRNA"}
{"X":45023,"RHEA_ID":43390,"compounds":"1D-myo-inositol 3-phosphate + phosphate => 1D-myo-inositol 3,4-bisphosphate + H2O"}
{"X":45024,"RHEA_ID":43391,"compounds":"1D-myo-inositol 3,4-bisphosphate + H2O <=> 1D-myo-inositol 3-phosphate + phosphate"}
{"X":45025,"RHEA_ID":53384,"compounds":"5,10-methylenetetrahydromethanopterin + NAD(+) = 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADH"}
{"X":45026,"RHEA_ID":43393,"DIRECTION":"LR","MASTER_ID":43392,"reactome":"R-HSA-1855180.2","compounds":"1D-myo-inositol 1,3,4-trisphosphate + H2O => 1D-myo-inositol 1,3-bisphosphate + phosphate"}
{"X":45027,"RHEA_ID":43394,"compounds":"1D-myo-inositol 1,3-bisphosphate + phosphate => 1D-myo-inositol 1,3,4-trisphosphate + H2O"}
{"X":45028,"RHEA_ID":56721,"DIRECTION":"LR","MASTER_ID":56720,"metacyc":"RXN-11951","compounds":"2 [Fe(III)cytochrome c] + L-cysteinyl-[SoxY protein] + thiosulfate => 2 [Fe(II)cytochrome c] + 2 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]"}
{"X":45029,"RHEA_ID":53388,"compounds":"5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + UDP-alpha-D-glucuronate = 5alpha-dihydrotestosterone 17-O-[beta-D-glucuronosyl-(1->2)-glucuronate] + H(+) + UDP"}
{"X":45030,"RHEA_ID":43397,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ATP => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol 3,4,5-triphosphate) + ADP + H(+)"}
{"X":45031,"RHEA_ID":43398,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol 3,4,5-triphosphate) + ADP + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ATP"}
{"X":45032,"RHEA_ID":53391,"compounds":"5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + UDP-alpha-D-glucuronate <=> 5alpha-dihydrotestosterone 17-O-[beta-D-glucuronosyl-(1->2)-glucuronate] + H(+) + UDP"}
{"X":45033,"RHEA_ID":53392,"DIRECTION":"UN","MASTER_ID":53392,"ec":"1.14.14.54","compounds":"2-phenylacetate + O2 + reduced [NADPH--hemoprotein reductase] = (2-hydroxyphenyl)acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":45034,"RHEA_ID":43401,"compounds":"N-(2-hydroxy-hexanoyl)-sphing-4-enine + UDP-alpha-D-galactose => H(+) + N-(2-hydroxy-hexanoyl)-beta-D-galactosyl-sphing-4-enine + UDP"}
{"X":45035,"RHEA_ID":43402,"compounds":"H(+) + N-(2-hydroxy-hexanoyl)-beta-D-galactosyl-sphing-4-enine + UDP => N-(2-hydroxy-hexanoyl)-sphing-4-enine + UDP-alpha-D-galactose"}
{"X":45036,"RHEA_ID":43403,"compounds":"N-(2-hydroxy-hexanoyl)-sphing-4-enine + UDP-alpha-D-galactose <=> H(+) + N-(2-hydroxy-hexanoyl)-beta-D-galactosyl-sphing-4-enine + UDP"}
{"X":45037,"RHEA_ID":53396,"DIRECTION":"UN","MASTER_ID":53396,"ec":"2.4.1.109","compounds":"dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + dolichyl phosphate + H(+)"}
{"X":45038,"RHEA_ID":53397,"DIRECTION":"LR","MASTER_ID":53396,"metacyc":"2.4.1.109-RXN","compounds":"dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] => 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + dolichyl phosphate + H(+)"}
{"X":45039,"RHEA_ID":43406,"compounds":"H(+) + N-(2-hydroxyhexanoyl)-beta-D-galactosylsphinganine + UDP => N-(2-hydroxy-hexanoyl)-sphinganine + UDP-alpha-D-galactose"}
{"X":45040,"RHEA_ID":43408,"compounds":"sphinganine + UDP-alpha-D-galactose = beta-D-galactosyl-(1<->1')-sphinganine + H(+) + UDP"}
{"X":45041,"RHEA_ID":53401,"compounds":"(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => (13S)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate"}
{"X":45042,"RHEA_ID":43410,"compounds":"beta-D-galactosyl-(1<->1')-sphinganine + H(+) + UDP => sphinganine + UDP-alpha-D-galactose"}
{"X":45043,"RHEA_ID":53403,"compounds":"(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate <=> (13S)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate"}
{"X":45044,"RHEA_ID":53404,"compounds":"(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 13-hydroxy-(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate"}
{"X":45045,"RHEA_ID":43413,"compounds":"a D-galactosylceramide + H2O => D-galactose + N-acyl-sphingoid base"}
{"X":45046,"RHEA_ID":43414,"compounds":"D-galactose + N-acyl-sphingoid base => a D-galactosylceramide + H2O"}
{"X":45047,"RHEA_ID":43415,"compounds":"a D-galactosylceramide + H2O <=> D-galactose + N-acyl-sphingoid base"}
{"X":45048,"RHEA_ID":53408,"compounds":"(1S,4R)-1-hydroxylimonen-2-one + H(+) + NADPH + O2 = (4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)"}
{"X":45049,"RHEA_ID":53409,"DIRECTION":"LR","MASTER_ID":53408,"metacyc":"RXN-9416","compounds":"(1S,4R)-1-hydroxylimonen-2-one + H(+) + NADPH + O2 => (4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)"}
{"X":45050,"RHEA_ID":43418,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP"}
{"X":45051,"RHEA_ID":43419,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":45052,"RHEA_ID":43420,"compounds":"1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + ATP = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":45053,"RHEA_ID":46716,"DIRECTION":"UN","MASTER_ID":46716,"ec":"2.1.1.260","compounds":"pseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylpseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-homocysteine"}
{"X":45054,"RHEA_ID":43422,"compounds":"1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+) => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + ATP"}
{"X":45055,"RHEA_ID":43423,"compounds":"1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + ATP <=> 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":45056,"RHEA_ID":43424,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":45057,"RHEA_ID":46720,"compounds":"(3R)-hydroxyhexanoyl-CoA = (2E)-hexenoyl-CoA + H2O"}
{"X":45058,"RHEA_ID":43426,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP"}
{"X":45059,"RHEA_ID":43427,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":45060,"RHEA_ID":43428,"compounds":"1,2-didecanoyl-sn-glycerol + ATP = 1,2-didecanoyl-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":45061,"RHEA_ID":46724,"compounds":"(2S)-2-methyltetradecanoyl-CoA = (2R)-2-methyltetradecanoyl-CoA"}
{"X":45062,"RHEA_ID":43430,"compounds":"1,2-didecanoyl-sn-glycero-3-phosphate + ADP + H(+) => 1,2-didecanoyl-sn-glycerol + ATP"}
{"X":45063,"RHEA_ID":43431,"compounds":"1,2-didecanoyl-sn-glycerol + ATP <=> 1,2-didecanoyl-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":45064,"RHEA_ID":43432,"DIRECTION":"UN","MASTER_ID":43432,"ec":"1.1.2.9","compounds":"2 [Fe(III)cytochrome c] + butan-1-ol = 2 [Fe(II)cytochrome c] + butanal + 2 H(+)"}
{"X":45065,"RHEA_ID":46728,"compounds":"(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + O2 = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O2"}
{"X":45066,"RHEA_ID":43434,"compounds":"2 [Fe(II)cytochrome c] + butanal + 2 H(+) => 2 [Fe(III)cytochrome c] + butan-1-ol"}
{"X":45067,"RHEA_ID":43436,"DIRECTION":"UN","MASTER_ID":43436,"ec":"1.3.3.15","compounds":"coproporphyrinogen III + 3 O2 = coproporphyrin III + 3 H2O2"}
{"X":45068,"RHEA_ID":46732,"compounds":"(2R,6)-dimethylheptanoyl-CoA = (2S,6)-dimethylheptanoyl-CoA"}
{"X":45069,"RHEA_ID":43438,"compounds":"coproporphyrin III + 3 H2O2 => coproporphyrinogen III + 3 O2"}
{"X":45070,"RHEA_ID":53431,"compounds":"a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] <=> a thymidine in DNA + S-methyl-L-cysteinyl-[protein]"}
{"X":45071,"RHEA_ID":43440,"compounds":"hexadecanoate + sphinganine = H2O + N-hexadecanoylsphinganine"}
{"X":45072,"RHEA_ID":46736,"compounds":"H2O + monoacyl-sn-glycero-3-phosphate = a monoacylglycerol + phosphate"}
{"X":45073,"RHEA_ID":43442,"compounds":"H2O + N-hexadecanoylsphinganine => hexadecanoate + sphinganine"}
{"X":45074,"RHEA_ID":43443,"compounds":"hexadecanoate + sphinganine <=> H2O + N-hexadecanoylsphinganine"}
{"X":45075,"RHEA_ID":43444,"compounds":"1,2-ditetradecanoyl-sn-glycerol + ATP = 1,2-ditetradecanoyl-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":45076,"RHEA_ID":46740,"compounds":"cholesta-5,7,24-trien-3beta-ol + H(+) + NADPH = cholesta-5,24-dien-3beta-ol + NADP(+)"}
{"X":45077,"RHEA_ID":43446,"compounds":"1,2-ditetradecanoyl-sn-glycero-3-phosphate + ADP + H(+) => 1,2-ditetradecanoyl-sn-glycerol + ATP"}
{"X":45078,"RHEA_ID":43447,"compounds":"1,2-ditetradecanoyl-sn-glycerol + ATP <=> 1,2-ditetradecanoyl-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":45079,"RHEA_ID":43448,"compounds":"H(+) + hexadecanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":45080,"RHEA_ID":53441,"compounds":"leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":45081,"RHEA_ID":43450,"compounds":"(2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + hexadecanoyl-CoA + oxidized [electron-transfer flavoprotein]"}
{"X":45082,"RHEA_ID":43451,"compounds":"H(+) + hexadecanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> (2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":45083,"RHEA_ID":43452,"compounds":"2 H(+) + hexanoyl-CoA + 2 malonyl-CoA = 4-hydroxy-6-pentylpyran-2-one + 2 CO2 + 3 CoA"}
{"X":45084,"RHEA_ID":53445,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 11beta,17beta-dihydroxyandrost-4-ene-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":45085,"RHEA_ID":43454,"compounds":"4-hydroxy-6-pentylpyran-2-one + 2 CO2 + 3 CoA => 2 H(+) + hexanoyl-CoA + 2 malonyl-CoA"}
{"X":45086,"RHEA_ID":53447,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 11beta,17beta-dihydroxyandrost-4-ene-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":45087,"RHEA_ID":43456,"compounds":"H(+) + oxidized [electron-transfer flavoprotein] + pentanoyl-CoA = (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":45088,"RHEA_ID":53449,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol => 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate"}
{"X":45089,"RHEA_ID":43458,"compounds":"(2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + pentanoyl-CoA"}
{"X":45090,"RHEA_ID":56785,"DIRECTION":"LR","MASTER_ID":56784,"metacyc":"RXN-3741","compounds":"(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n + (n-1) H2O => (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate"}
{"X":45091,"RHEA_ID":43460,"compounds":"dodecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-undecylpyran-2-one + 2 CO2 + 3 CoA"}
{"X":45092,"RHEA_ID":53453,"compounds":"1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + cholesterol => 1-hexadecanoyl-sn-glycero-3-phosphocholine + a cholesterol ester"}
{"X":45093,"RHEA_ID":43462,"compounds":"4-hydroxy-6-undecylpyran-2-one + 2 CO2 + 3 CoA => dodecanoyl-CoA + 2 H(+) + 2 malonyl-CoA"}
{"X":45094,"RHEA_ID":53455,"compounds":"1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + cholesterol <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + a cholesterol ester"}
{"X":45095,"RHEA_ID":43464,"compounds":"H(+) + hexanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":45096,"RHEA_ID":53457,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + cholesterol => 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z-octadecenoate)"}
{"X":45097,"RHEA_ID":43466,"compounds":"(2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + hexanoyl-CoA + oxidized [electron-transfer flavoprotein]"}
{"X":45098,"RHEA_ID":46762,"compounds":"4-methyl-5-nitrocatechol + NAD(+) + nitrite => 2,4-dinitrotoluene + NADH + O2"}
{"X":45099,"RHEA_ID":43468,"compounds":"(8Z,11Z,14Z)-eicosatrienoate + O2 = (8Z,10E,14Z)-12-hydroperoxyeicosatrienoate"}
{"X":45100,"RHEA_ID":53461,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol => 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z)-eicosatrienoate"}
{"X":45101,"RHEA_ID":43470,"compounds":"(8Z,10E,14Z)-12-hydroperoxyeicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2"}
{"X":45102,"RHEA_ID":53463,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z)-eicosatrienoate"}
{"X":45103,"RHEA_ID":43472,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate"}
{"X":45104,"RHEA_ID":53465,"compounds":"1-hexadecanoyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol => 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (8Z,11Z,14Z)-eicosatrienoate"}
{"X":45105,"RHEA_ID":43474,"compounds":"14-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2"}
{"X":45106,"RHEA_ID":53467,"compounds":"1-hexadecanoyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (8Z,11Z,14Z)-eicosatrienoate"}
{"X":45107,"RHEA_ID":43476,"compounds":"(6Z,9Z,12Z)-octadecatrienoate + O2 = 10-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate"}
{"X":45108,"RHEA_ID":53469,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phosphocholine + cholesterol => 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z,14Z,17Z-eicosapentaenoate)"}
{"X":45109,"RHEA_ID":43478,"compounds":"10-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate => (6Z,9Z,12Z)-octadecatrienoate + O2"}
{"X":45110,"RHEA_ID":43479,"compounds":"(6Z,9Z,12Z)-octadecatrienoate + O2 <=> 10-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate"}
{"X":45111,"RHEA_ID":43480,"compounds":"1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl-8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate"}
{"X":45112,"RHEA_ID":53473,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + cholesterol => 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z,12Z)-octadecadienoate"}
{"X":45113,"RHEA_ID":43482,"compounds":"1-O-methyl-8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => 1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2"}
{"X":45114,"RHEA_ID":53475,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + cholesterol <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z,12Z)-octadecadienoate"}
{"X":45115,"RHEA_ID":43484,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)"}
{"X":45116,"RHEA_ID":53477,"compounds":"1-hexadecanoyl-2-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol => 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (6Z,9Z,12Z)-octadecatrienoate"}
{"X":45117,"RHEA_ID":43486,"compounds":"1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O"}
{"X":45118,"RHEA_ID":43487,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)"}
{"X":45119,"RHEA_ID":43488,"DIRECTION":"UN","MASTER_ID":43488,"ec":"1.1.1.294","compounds":"7(1)-hydroxychlorophyll a + NAD(+) = chlorophyll b + H(+) + NADH"}
{"X":45120,"RHEA_ID":53481,"compounds":"3beta-hydroxy-5alpha-androstan-17-one + H(+) + NADPH => 5alpha-androstane-3beta,17beta-diol + NADP(+)"}
{"X":45121,"RHEA_ID":43490,"DIRECTION":"RL","MASTER_ID":43488,"metacyc":"RXN-7678","compounds":"chlorophyll b + H(+) + NADH => 7(1)-hydroxychlorophyll a + NAD(+)"}
{"X":45122,"RHEA_ID":46785,"DIRECTION":"LR","MASTER_ID":46784,"metacyc":"RXN-16071","compounds":"a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-[(9Z,12Z,15Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":45123,"RHEA_ID":43492,"DIRECTION":"UN","MASTER_ID":43492,"ec":"1.1.1.294","compounds":"7(1)-hydroxychlorophyll a + NADP(+) = chlorophyll b + H(+) + NADPH"}
{"X":45124,"RHEA_ID":53485,"compounds":"androst-4-ene-3,11,17-trione + H(+) + NADPH => 17beta-hydroxyandrost-4-ene-3,11-dione + NADP(+)"}
{"X":45125,"RHEA_ID":43494,"DIRECTION":"RL","MASTER_ID":43492,"metacyc":"RXN-7678","compounds":"chlorophyll b + H(+) + NADPH => 7(1)-hydroxychlorophyll a + NADP(+)"}
{"X":45126,"RHEA_ID":53487,"compounds":"androst-4-ene-3,11,17-trione + H(+) + NADPH <=> 17beta-hydroxyandrost-4-ene-3,11-dione + NADP(+)"}
{"X":45127,"RHEA_ID":43496,"DIRECTION":"UN","MASTER_ID":43496,"ec":"1.1.1.380","compounds":"L-gulonate + NAD(+) = H(+) + keto-D-fructuronate + NADH"}
{"X":45128,"RHEA_ID":46791,"compounds":"a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-[(6Z,9Z,12Z,15Z)-octadectetraenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":45129,"RHEA_ID":43498,"compounds":"H(+) + keto-D-fructuronate + NADH => L-gulonate + NAD(+)"}
{"X":45130,"RHEA_ID":46793,"DIRECTION":"LR","MASTER_ID":46792,"metacyc":"RXN-16099","compounds":"2 [Fe(II)-cytochrome b5] + an (11Z,14Z)-icosadienoyl-containing glycerolipid + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 H2O"}
{"X":45131,"RHEA_ID":43500,"DIRECTION":"UN","MASTER_ID":43500,"ec":"1.1.1.203","compounds":"beta-D-glucuronate + NAD(+) = D-glucaro-1,5-lactone + H(+) + NADH"}
{"X":45132,"RHEA_ID":53493,"compounds":"5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(in) => 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na(+)(out)"}
{"X":45133,"RHEA_ID":43502,"compounds":"D-glucaro-1,5-lactone + H(+) + NADH => beta-D-glucuronate + NAD(+)"}
{"X":45134,"RHEA_ID":46797,"DIRECTION":"LR","MASTER_ID":46796,"metacyc":"RXN-16101","compounds":"2 [Fe(II)-cytochrome b5] + an (11Z,14Z,17Z)-icosatrienoyl-containing glycerolipid + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 H2O"}
{"X":45135,"RHEA_ID":43504,"compounds":"5-hydroxymethylfurfural + O2 = 2,5-diformylfuran + H2O2"}
{"X":45136,"RHEA_ID":53497,"compounds":"1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O => a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexanoate"}
{"X":45137,"RHEA_ID":43506,"compounds":"2,5-diformylfuran + H2O2 => 5-hydroxymethylfurfural + O2"}
{"X":45138,"RHEA_ID":46801,"DIRECTION":"LR","MASTER_ID":46800,"metacyc":"TRANS-RXN-276","compounds":"H(+) + Na(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] => Na(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":45139,"RHEA_ID":43508,"compounds":"2,5-diformylfuran + H2O = 2-(dihydroxymethyl)-5-formylfuran"}
{"X":45140,"RHEA_ID":43509,"DIRECTION":"LR","MASTER_ID":43508,"metacyc":"RXN-15852","compounds":"2,5-diformylfuran + H2O => 2-(dihydroxymethyl)-5-formylfuran"}
{"X":45141,"RHEA_ID":43510,"compounds":"2-(dihydroxymethyl)-5-formylfuran => 2,5-diformylfuran + H2O"}
{"X":45142,"RHEA_ID":60257,"DIRECTION":"LR","MASTER_ID":60256,"metacyc":"RXN66-608","compounds":"A + H2O + N(6)-methyl-L-lysyl(4)-[histone H3] => AH2 + formaldehyde + L-lysyl(4)-[histone H3]"}
{"X":45143,"RHEA_ID":43512,"compounds":"2-(dihydroxymethyl)-5-formylfuran + O2 = 2-carboxy-5-formylfuran + H(+) + H2O2"}
{"X":45144,"RHEA_ID":43513,"DIRECTION":"LR","MASTER_ID":43512,"metacyc":"RXN-13091","compounds":"2-(dihydroxymethyl)-5-formylfuran + O2 => 2-carboxy-5-formylfuran + H(+) + H2O2"}
{"X":45145,"RHEA_ID":46808,"DIRECTION":"UN","MASTER_ID":46808,"ec":"2.1.1.318","compounds":"[trehalose-6-phosphate synthase]-L-cysteine + S-adenosyl-L-methionine = [trehalose-6-phosphate synthase]-S-methyl-L-cysteine + H(+) + S-adenosyl-L-homocysteine"}
{"X":45146,"RHEA_ID":60261,"DIRECTION":"LR","MASTER_ID":60260,"metacyc":"RXN-20616","compounds":"L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine"}
{"X":45147,"RHEA_ID":43516,"compounds":"2-carboxy-5-formylfuran + H2O = 2-carboxy-5-(dihydroxymethyl)furan"}
{"X":45148,"RHEA_ID":46811,"compounds":"[trehalose-6-phosphate synthase]-L-cysteine + S-adenosyl-L-methionine <=> [trehalose-6-phosphate synthase]-S-methyl-L-cysteine + H(+) + S-adenosyl-L-homocysteine"}
{"X":45149,"RHEA_ID":43518,"compounds":"2-carboxy-5-(dihydroxymethyl)furan => 2-carboxy-5-formylfuran + H2O"}
{"X":45150,"RHEA_ID":46813,"compounds":"4,4-dimethyl-8,14-cholestadien-3beta-ol + H(+) + NADPH => 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)"}
{"X":45151,"RHEA_ID":43520,"compounds":"2-carboxy-5-(dihydroxymethyl)furan + O2 = 2,5-dicarboxyfuran + H(+) + H2O2"}
{"X":45152,"RHEA_ID":53512,"compounds":"(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O = (13R)-S-cysteinylglycinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + L-glutamate"}
{"X":45153,"RHEA_ID":43522,"compounds":"2,5-dicarboxyfuran + H(+) + H2O2 => 2-carboxy-5-(dihydroxymethyl)furan + O2"}
{"X":45154,"RHEA_ID":46817,"compounds":"4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":45155,"RHEA_ID":43524,"DIRECTION":"UN","MASTER_ID":43524,"ec":"1.1.1.381","compounds":"L-allo-threonine + NADP(+) = aminoacetone + CO2 + NADPH"}
{"X":45156,"RHEA_ID":46819,"compounds":"4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":45157,"RHEA_ID":43526,"compounds":"aminoacetone + CO2 + NADPH => L-allo-threonine + NADP(+)"}
{"X":45158,"RHEA_ID":46821,"compounds":"4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":45159,"RHEA_ID":43528,"compounds":"L-serine + NAD(+) = 2-aminomalonate semialdehyde + H(+) + NADH"}
{"X":45160,"RHEA_ID":53520,"compounds":"1-hexadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z,12Z,15Z)-octadecatrienoate"}
{"X":45161,"RHEA_ID":43530,"compounds":"2-aminomalonate semialdehyde + H(+) + NADH => L-serine + NAD(+)"}
{"X":45162,"RHEA_ID":46825,"compounds":"4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 => 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":45163,"RHEA_ID":43532,"DIRECTION":"UN","MASTER_ID":43532,"ec":"3.1.3.97","compounds":"a ribonucleoside 3',5'-bisphosphate + H2O = a ribonucleoside 5'-phosphate + phosphate"}
{"X":45164,"RHEA_ID":53524,"compounds":"1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine = a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":45165,"RHEA_ID":43534,"compounds":"a ribonucleoside 5'-phosphate + phosphate => a ribonucleoside 3',5'-bisphosphate + H2O"}
{"X":45166,"RHEA_ID":53526,"compounds":"a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine => 1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":45167,"RHEA_ID":43536,"DIRECTION":"UN","MASTER_ID":43536,"ec":"4.2.3.153","compounds":"2 D-glyceraldehyde 3-phosphate = 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + 2 H2O + phosphate"}
{"X":45168,"RHEA_ID":43537,"DIRECTION":"LR","MASTER_ID":43536,"metacyc":"RXN-15946","compounds":"2 D-glyceraldehyde 3-phosphate => 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + 2 H2O + phosphate"}
{"X":45169,"RHEA_ID":43538,"compounds":"4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + 2 H2O + phosphate => 2 D-glyceraldehyde 3-phosphate"}
{"X":45170,"RHEA_ID":53530,"compounds":"2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-(9Z-octadecenoyl)-1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine => 1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":45171,"RHEA_ID":43540,"DIRECTION":"UN","MASTER_ID":43540,"ec":"2.7.11.5","compounds":"[isocitrate dehydrogenase]-L-serine + ATP = [isocitrate dehydrogenase]-O-phospho-L-serine + ADP + H(+)"}
{"X":45172,"RHEA_ID":53532,"compounds":"(14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate = (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O"}
{"X":45173,"RHEA_ID":43542,"compounds":"[isocitrate dehydrogenase]-O-phospho-L-serine + ADP + H(+) => [isocitrate dehydrogenase]-L-serine + ATP"}
{"X":45174,"RHEA_ID":46837,"compounds":"4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":45175,"RHEA_ID":43544,"DIRECTION":"UN","MASTER_ID":43544,"ec":"6.3.4.24","compounds":"ATP + L-glutamate + tyramine = ADP + gamma-L-glutamyltyramine + H(+) + phosphate"}
{"X":45176,"RHEA_ID":53536,"compounds":"(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O = (13R,14S)-dihydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate"}
{"X":45177,"RHEA_ID":43546,"compounds":"ADP + gamma-L-glutamyltyramine + H(+) + phosphate => ATP + L-glutamate + tyramine"}
{"X":45178,"RHEA_ID":46841,"compounds":"4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":45179,"RHEA_ID":43548,"compounds":"1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate"}
{"X":45180,"RHEA_ID":43549,"compounds":"1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate"}
{"X":45181,"RHEA_ID":53541,"DIRECTION":"LR","MASTER_ID":53540,"reactome":"R-HSA-9026771.2","compounds":"(13R)-S-cysteinylglycinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O => (13R)-S-cysteinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glycine"}
{"X":45182,"RHEA_ID":53542,"compounds":"(13R)-S-cysteinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glycine => (13R)-S-cysteinylglycinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O"}
{"X":45183,"RHEA_ID":43552,"compounds":"1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate"}
{"X":45184,"RHEA_ID":43553,"compounds":"1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate"}
{"X":45185,"RHEA_ID":53545,"compounds":"chlorophyll a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 7(1)-hydroxychlorophyll a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":45186,"RHEA_ID":53546,"DIRECTION":"RL","MASTER_ID":53544,"metacyc":"RXN-7679","compounds":"7(1)-hydroxychlorophyll a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => chlorophyll a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":45187,"RHEA_ID":43556,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate"}
{"X":45188,"RHEA_ID":43557,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate"}
{"X":45189,"RHEA_ID":53549,"DIRECTION":"LR","MASTER_ID":53548,"reactome":"R-HSA-2161563.2","compounds":"prostaglandin J2 => Delta(12)-prostaglandin J2"}
{"X":45190,"RHEA_ID":43559,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate"}
{"X":45191,"RHEA_ID":43560,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate"}
{"X":45192,"RHEA_ID":43561,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate"}
{"X":45193,"RHEA_ID":53553,"compounds":"(9S,10R)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-(9S,10R)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":45194,"RHEA_ID":53554,"compounds":"18-hydroxy-(9S,10R)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9S,10R)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":45195,"RHEA_ID":43564,"DIRECTION":"UN","MASTER_ID":43564,"ec":"2.6.1.108","compounds":"4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + L-alanine = [5-(aminomethyl)-3-furyl]methyl phosphate + pyruvate"}
{"X":45196,"RHEA_ID":43565,"DIRECTION":"LR","MASTER_ID":43564,"metacyc":"RXN-8119","compounds":"4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + L-alanine => [5-(aminomethyl)-3-furyl]methyl phosphate + pyruvate"}
{"X":45197,"RHEA_ID":53557,"compounds":"(9R,10S)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-(9R,10S)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":45198,"RHEA_ID":53558,"compounds":"18-hydroxy-(9R,10S)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9R,10S)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":45199,"RHEA_ID":43568,"DIRECTION":"UN","MASTER_ID":43568,"ec":"1.2.1.92","compounds":"3,6-anhydro-alpha-L-galactopyranose + H2O + NAD(+) = 3,6-anhydro-L-galactonate + 2 H(+) + NADH"}
{"X":45200,"RHEA_ID":43569,"DIRECTION":"LR","MASTER_ID":43568,"metacyc":"RXN-18853","compounds":"3,6-anhydro-alpha-L-galactopyranose + H2O + NAD(+) => 3,6-anhydro-L-galactonate + 2 H(+) + NADH"}
{"X":45201,"RHEA_ID":53561,"compounds":"9,10-epoxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-9,10-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":45202,"RHEA_ID":46869,"compounds":"1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA (E. coli) => a 2-acyl-sn-glycero-3-phosphocholine + lipid IVB"}
{"X":45203,"RHEA_ID":43572,"DIRECTION":"UN","MASTER_ID":43572,"ec":"1.4.99.6","compounds":"A + D-arginine + H2O = 5-guanidino-2-oxopentanoate + AH2 + NH4(+)"}
{"X":45204,"RHEA_ID":43573,"compounds":"A + D-arginine + H2O => 5-guanidino-2-oxopentanoate + AH2 + NH4(+)"}
{"X":45205,"RHEA_ID":53565,"compounds":"9,10-epoxy-(12Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-9,10-epoxy-(12Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":45206,"RHEA_ID":53566,"compounds":"18-hydroxy-9,10-epoxy-(12Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9,10-epoxy-(12Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":45207,"RHEA_ID":43576,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + phosphate"}
{"X":45208,"RHEA_ID":43577,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + phosphate"}
{"X":45209,"RHEA_ID":43578,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O"}
{"X":45210,"RHEA_ID":53570,"compounds":"18-hydroxy-12,13-epoxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 12,13-epoxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":45211,"RHEA_ID":43580,"compounds":"A + D-arginine = AH2 + iminoarginine"}
{"X":45212,"RHEA_ID":43581,"DIRECTION":"LR","MASTER_ID":43580,"metacyc":"RXN-15849","compounds":"A + D-arginine => AH2 + iminoarginine"}
{"X":45213,"RHEA_ID":43582,"compounds":"AH2 + iminoarginine => A + D-arginine"}
{"X":45214,"RHEA_ID":46881,"compounds":"3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP"}
{"X":45215,"RHEA_ID":43584,"compounds":"H2O + iminoarginine = 5-guanidino-2-oxopentanoate + NH4(+)"}
{"X":45216,"RHEA_ID":43585,"DIRECTION":"LR","MASTER_ID":43584,"metacyc":"RXN-15850","compounds":"H2O + iminoarginine => 5-guanidino-2-oxopentanoate + NH4(+)"}
{"X":45217,"RHEA_ID":53577,"compounds":"11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":45218,"RHEA_ID":46885,"compounds":"3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP"}
{"X":45219,"RHEA_ID":43588,"compounds":"globoside NORint + UDP-alpha-D-galactose = globoside NOR2 + H(+) + UDP"}
{"X":45220,"RHEA_ID":43589,"compounds":"globoside NORint + UDP-alpha-D-galactose => globoside NOR2 + H(+) + UDP"}
{"X":45221,"RHEA_ID":53581,"compounds":"14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":45222,"RHEA_ID":43592,"compounds":"all-trans-zeaxanthin + O2 = (3R)-3-hydroxy-8'-apo-beta-carotenal + 3beta-hydroxy-beta-cyclocitral"}
{"X":45223,"RHEA_ID":43593,"DIRECTION":"LR","MASTER_ID":43592,"metacyc":"RXN-15979","compounds":"all-trans-zeaxanthin + O2 => (3R)-3-hydroxy-8'-apo-beta-carotenal + 3beta-hydroxy-beta-cyclocitral"}
{"X":45224,"RHEA_ID":53585,"compounds":"NAD(+) + resolvin D2 => 7-oxoresolvin D2 + H(+) + NADH"}
{"X":45225,"RHEA_ID":53586,"compounds":"7-oxoresolvin D2 + H(+) + NADH => NAD(+) + resolvin D2"}
{"X":45226,"RHEA_ID":43596,"compounds":"(3R)-3-hydroxy-8'-apo-beta-carotenal + O2 = 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde"}
{"X":45227,"RHEA_ID":43597,"DIRECTION":"LR","MASTER_ID":43596,"metacyc":"RXN-15980","compounds":"(3R)-3-hydroxy-8'-apo-beta-carotenal + O2 => 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde"}
{"X":45228,"RHEA_ID":53589,"compounds":"NAD(+) + resolvin D2 => 16-oxoresolvin D2 + H(+) + NADH"}
{"X":45229,"RHEA_ID":53590,"compounds":"16-oxoresolvin D2 + H(+) + NADH => NAD(+) + resolvin D2"}
{"X":45230,"RHEA_ID":43600,"compounds":"3-oxoeicosanoyl-[ACP] + H(+) + NADPH = 3R-hydroxyeicosanoyl-[ACP] + NADP(+)"}
{"X":45231,"RHEA_ID":53592,"compounds":"1-tetradecanoyl-sn-glycerol 3-phosphate + H2O = 1-tetradecanoyl-sn-glycerol + phosphate"}
{"X":45232,"RHEA_ID":53593,"compounds":"1-tetradecanoyl-sn-glycerol 3-phosphate + H2O => 1-tetradecanoyl-sn-glycerol + phosphate"}
{"X":45233,"RHEA_ID":43603,"compounds":"3-oxoeicosanoyl-[ACP] + H(+) + NADPH <=> 3R-hydroxyeicosanoyl-[ACP] + NADP(+)"}
{"X":45234,"RHEA_ID":43604,"DIRECTION":"UN","MASTER_ID":43604,"ec":"1.17.7.3","compounds":"(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]"}
{"X":45235,"RHEA_ID":43605,"compounds":"(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] => 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]"}
{"X":45236,"RHEA_ID":53597,"compounds":"1-octadecanoyl-sn-glycero-3-phosphate + H2O => 1-octadecanoyl-sn-glycerol + phosphate"}
{"X":45237,"RHEA_ID":46905,"DIRECTION":"LR","MASTER_ID":46904,"metacyc":"RXN-16284","compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A hexaacyl 1-(2-aminoethyl diphosphate) => a 1,2-diacyl-sn-glycerol + lipid A 1,4'-bis(2-aminoethyl diphosphate)"}
{"X":45238,"RHEA_ID":43608,"DIRECTION":"UN","MASTER_ID":43608,"ec":"6.3.4.22","compounds":"agmatine + ATP + cytidine(34) in tRNA(Ile2) + H2O = 2-agmatinylcytidine(34) in tRNA(Ile2) + AMP + 2 H(+) + 2 phosphate"}
{"X":45239,"RHEA_ID":43609,"DIRECTION":"LR","MASTER_ID":43608,"metacyc":"RXN-14344","compounds":"agmatine + ATP + cytidine(34) in tRNA(Ile2) + H2O => 2-agmatinylcytidine(34) in tRNA(Ile2) + AMP + 2 H(+) + 2 phosphate"}
{"X":45240,"RHEA_ID":43610,"compounds":"2-agmatinylcytidine(34) in tRNA(Ile2) + AMP + 2 H(+) + 2 phosphate => agmatine + ATP + cytidine(34) in tRNA(Ile2) + H2O"}
{"X":45241,"RHEA_ID":46909,"DIRECTION":"LR","MASTER_ID":46908,"ecocyc":"RXN0-4581","metacyc":"RXN0-4581","compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA => 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + a 1,2-diacyl-sn-glycerol"}
{"X":45242,"RHEA_ID":43612,"compounds":"S-adenosyl-L-methionine + uridine(341) in tmRNA = 5-methyluridine(341) in tmRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":45243,"RHEA_ID":43613,"compounds":"S-adenosyl-L-methionine + uridine(341) in tmRNA => 5-methyluridine(341) in tmRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":45244,"RHEA_ID":53605,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphate + H2O => 1-hexadecanoyl-sn-glycerol + phosphate"}
{"X":45245,"RHEA_ID":43615,"compounds":"S-adenosyl-L-methionine + uridine(341) in tmRNA <=> 5-methyluridine(341) in tmRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":45246,"RHEA_ID":53607,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphate + H2O <=> 1-hexadecanoyl-sn-glycerol + phosphate"}
{"X":45247,"RHEA_ID":43617,"DIRECTION":"LR","MASTER_ID":43616,"ecocyc":"RXN-11361","metacyc":"RXN-11361","compounds":"[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) => [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate"}
{"X":45248,"RHEA_ID":53609,"compounds":"4-hydroxyestrone + O2 => (2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + H(+)"}
{"X":45249,"RHEA_ID":53611,"compounds":"4-hydroxyestrone + O2 <=> (2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + H(+)"}
{"X":45250,"RHEA_ID":53612,"compounds":"CTP + D-ribulose 5-phosphate + H(+) = CDP-D-ribulose + diphosphate"}
{"X":45251,"RHEA_ID":53613,"compounds":"CTP + D-ribulose 5-phosphate + H(+) => CDP-D-ribulose + diphosphate"}
{"X":45252,"RHEA_ID":53614,"compounds":"CDP-D-ribulose + diphosphate => CTP + D-ribulose 5-phosphate + H(+)"}
{"X":45253,"RHEA_ID":53615,"compounds":"CTP + D-ribulose 5-phosphate + H(+) <=> CDP-D-ribulose + diphosphate"}
{"X":45254,"RHEA_ID":53616,"DIRECTION":"UN","MASTER_ID":53616,"ec":"4.2.3.157","compounds":"(2E,6E)-farnesyl diphosphate + H2O = (+)-isoafricanol + diphosphate"}
{"X":45255,"RHEA_ID":53617,"DIRECTION":"LR","MASTER_ID":53616,"metacyc":"RXN-18784","compounds":"(2E,6E)-farnesyl diphosphate + H2O => (+)-isoafricanol + diphosphate"}
{"X":45256,"RHEA_ID":46926,"compounds":"4-methylpent-2-enoyl-CoA + H2O => (R)-2-hydroxy-4-methylpentanoyl-CoA"}
{"X":45257,"RHEA_ID":43629,"compounds":"L-serine + NAD(+) => aminoacetaldehyde + CO2 + NADH"}
{"X":45258,"RHEA_ID":53621,"DIRECTION":"LR","MASTER_ID":53620,"metacyc":"RXN-18785","compounds":"all-trans-geranylgeranyl diphosphate => (-)-spiroviolene + diphosphate"}
{"X":45259,"RHEA_ID":53622,"compounds":"(-)-spiroviolene + diphosphate => all-trans-geranylgeranyl diphosphate"}
{"X":45260,"RHEA_ID":46930,"compounds":"a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol => a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol"}
{"X":45261,"RHEA_ID":43633,"compounds":"an N-terminal L-alpha-aminoacyl-[protein] + L-phenylalanyl-tRNA(Phe) => an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein] + tRNA(Phe)"}
{"X":45262,"RHEA_ID":53625,"DIRECTION":"LR","MASTER_ID":53624,"metacyc":"RXN-18786","compounds":"all-trans-geranylgeranyl diphosphate => diphosphate + tsukubadiene"}
{"X":45263,"RHEA_ID":43635,"compounds":"an N-terminal L-alpha-aminoacyl-[protein] + L-phenylalanyl-tRNA(Phe) <=> an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein] + tRNA(Phe)"}
{"X":45264,"RHEA_ID":43636,"DIRECTION":"UN","MASTER_ID":43636,"ec":"2.3.1.286","compounds":"H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide"}
{"X":45265,"RHEA_ID":53628,"DIRECTION":"UN","MASTER_ID":53628,"ec":"4.2.3.160","compounds":"(2E,6E)-farnesyl diphosphate = (2S,3R,6S,9S)-(-)-protoillud-7-ene + diphosphate"}
{"X":45266,"RHEA_ID":53629,"DIRECTION":"LR","MASTER_ID":53628,"metacyc":"RXN-18787","compounds":"(2E,6E)-farnesyl diphosphate => (2S,3R,6S,9S)-(-)-protoillud-7-ene + diphosphate"}
{"X":45267,"RHEA_ID":43639,"compounds":"H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide"}
{"X":45268,"RHEA_ID":43640,"compounds":"dodecanoyl-CoA + H(+) + malonyl-[ACP] = 3-oxotetradecanoyl-[ACP] + CO2 + CoA"}
{"X":45269,"RHEA_ID":56966,"compounds":"a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate => a 2'-deoxyribonucleoside 5'-triphosphate + pyruvate"}
{"X":45270,"RHEA_ID":53633,"DIRECTION":"LR","MASTER_ID":53632,"metacyc":"RXN-18788","compounds":"(2E,6E)-farnesyl diphosphate => (3S)-(+)-asterisca-2(9),6-diene + diphosphate"}
{"X":45271,"RHEA_ID":43643,"compounds":"dodecanoyl-CoA + H(+) + malonyl-[ACP] <=> 3-oxotetradecanoyl-[ACP] + CO2 + CoA"}
{"X":45272,"RHEA_ID":43644,"compounds":"H(+) + malonyl-[ACP] + tetradecanoyl-CoA = 3-oxohexadecanoyl-[ACP] + CO2 + CoA"}
{"X":45273,"RHEA_ID":46943,"compounds":"AMP + diphosphate + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] <=> ATP + holo-[LYS2 peptidyl-carrier protein] + L-2-aminoadipate"}
{"X":45274,"RHEA_ID":53637,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphocholine"}
{"X":45275,"RHEA_ID":43647,"compounds":"H(+) + malonyl-[ACP] + tetradecanoyl-CoA <=> 3-oxohexadecanoyl-[ACP] + CO2 + CoA"}
{"X":45276,"RHEA_ID":43648,"compounds":"H(+) + hexadecanoyl-CoA + malonyl-[ACP] = 3-oxooctadecanoyl-[ACP] + CO2 + CoA"}
{"X":45277,"RHEA_ID":43649,"compounds":"H(+) + hexadecanoyl-CoA + malonyl-[ACP] => 3-oxooctadecanoyl-[ACP] + CO2 + CoA"}
{"X":45278,"RHEA_ID":53641,"DIRECTION":"LR","MASTER_ID":53640,"metacyc":"RXN-18789","compounds":"(2E,6E)-farnesyl diphosphate => (-)-alpha-amorphene + diphosphate"}
{"X":45279,"RHEA_ID":43651,"compounds":"H(+) + hexadecanoyl-CoA + malonyl-[ACP] <=> 3-oxooctadecanoyl-[ACP] + CO2 + CoA"}
{"X":45280,"RHEA_ID":43652,"compounds":"decanoyl-CoA + H(+) + malonyl-[ACP] = 3-oxododecanoyl-[ACP] + CO2 + CoA"}
{"X":45281,"RHEA_ID":53644,"DIRECTION":"UN","MASTER_ID":53644,"ec":"4.2.3.163","compounds":"(2E,6E)-farnesyl diphosphate + H2O = (+)-corvol ether B + diphosphate"}
{"X":45282,"RHEA_ID":53645,"DIRECTION":"LR","MASTER_ID":53644,"metacyc":"RXN-18790","compounds":"(2E,6E)-farnesyl diphosphate + H2O => (+)-corvol ether B + diphosphate"}
{"X":45283,"RHEA_ID":43655,"compounds":"decanoyl-CoA + H(+) + malonyl-[ACP] <=> 3-oxododecanoyl-[ACP] + CO2 + CoA"}
{"X":45284,"RHEA_ID":43656,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + CTP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CDP + H(+)"}
{"X":45285,"RHEA_ID":53648,"DIRECTION":"UN","MASTER_ID":53648,"ec":"4.2.3.171","compounds":"(2E,6E)-farnesyl diphosphate + H2O = (+)-corvol ether A + diphosphate"}
{"X":45286,"RHEA_ID":53649,"DIRECTION":"LR","MASTER_ID":53648,"metacyc":"RXN-18825","compounds":"(2E,6E)-farnesyl diphosphate + H2O => (+)-corvol ether A + diphosphate"}
{"X":45287,"RHEA_ID":43659,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + CTP <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CDP + H(+)"}
{"X":45288,"RHEA_ID":43660,"compounds":"ATP + hydrogencarbonate + propanoyl-CoA = ADP + H(+) + methylmalonyl-CoA + phosphate"}
{"X":45289,"RHEA_ID":53652,"compounds":"(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S,15S)-dihydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate"}
{"X":45290,"RHEA_ID":53653,"compounds":"(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 => (5S,15S)-dihydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate"}
{"X":45291,"RHEA_ID":43663,"compounds":"ATP + hydrogencarbonate + propanoyl-CoA <=> ADP + H(+) + methylmalonyl-CoA + phosphate"}
{"X":45292,"RHEA_ID":43664,"compounds":"ATP + hydrogencarbonate + tetracosanoyl-CoA = 2-carboxytetracosanoyl-CoA + ADP + H(+) + phosphate"}
{"X":45293,"RHEA_ID":53656,"compounds":"(5S,6R)-dihydroxy-(7E,9E,11Z,14Z)-eicosatetraenoate + O2 = (5S,6R)-dihydroxy-(15S)-hydroperoxy-(7E,9E,11Z,13E)-eicosatetraenoate"}
{"X":45294,"RHEA_ID":53657,"compounds":"(5S,6R)-dihydroxy-(7E,9E,11Z,14Z)-eicosatetraenoate + O2 => (5S,6R)-dihydroxy-(15S)-hydroperoxy-(7E,9E,11Z,13E)-eicosatetraenoate"}
{"X":45295,"RHEA_ID":43667,"compounds":"ATP + hydrogencarbonate + tetracosanoyl-CoA <=> 2-carboxytetracosanoyl-CoA + ADP + H(+) + phosphate"}
{"X":45296,"RHEA_ID":43668,"compounds":"ATP + hexacosanoyl-CoA + hydrogencarbonate = 2-carboxyhexacosanoyl-CoA + ADP + H(+) + phosphate"}
{"X":45297,"RHEA_ID":53660,"compounds":"(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S)-hydroxy-(15S)-hydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate"}
{"X":45298,"RHEA_ID":53661,"compounds":"(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 => (5S)-hydroxy-(15S)-hydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate"}
{"X":45299,"RHEA_ID":43671,"compounds":"ATP + hexacosanoyl-CoA + hydrogencarbonate <=> 2-carboxyhexacosanoyl-CoA + ADP + H(+) + phosphate"}
{"X":45300,"RHEA_ID":43672,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol = 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":45301,"RHEA_ID":53664,"compounds":"(2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + NH4(+) = H(+) + 2 H2O + pyridinestrone carboxylate"}
{"X":45302,"RHEA_ID":43674,"compounds":"1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol"}
{"X":45303,"RHEA_ID":43675,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol <=> 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":45304,"RHEA_ID":43676,"compounds":"(9Z)-octadecenoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":45305,"RHEA_ID":43677,"compounds":"(9Z)-octadecenoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":45306,"RHEA_ID":53669,"DIRECTION":"LR","MASTER_ID":53668,"metacyc":"RXN-18792","compounds":"(2E,6E)-farnesyl diphosphate => (1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate"}
{"X":45307,"RHEA_ID":43679,"compounds":"(9Z)-octadecenoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol <=> 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":45308,"RHEA_ID":43680,"compounds":"1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":45309,"RHEA_ID":43681,"compounds":"1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":45310,"RHEA_ID":53673,"compounds":"2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + AH2 + O2 => 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphoethanolamine + A + H2O"}
{"X":45311,"RHEA_ID":43683,"compounds":"1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA <=> 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA"}
{"X":45312,"RHEA_ID":43684,"DIRECTION":"UN","MASTER_ID":43684,"ec":"2.7.9.1","compounds":"ATP + L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphate = AMP + diphosphate + H(+) + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]"}
{"X":45313,"RHEA_ID":53676,"compounds":"2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O"}
{"X":45314,"RHEA_ID":43686,"compounds":"AMP + diphosphate + H(+) + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] => ATP + L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphate"}
{"X":45315,"RHEA_ID":43687,"compounds":"ATP + L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphate <=> AMP + diphosphate + H(+) + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]"}
{"X":45316,"RHEA_ID":43688,"DIRECTION":"UN","MASTER_ID":43688,"ec":"2.7.9.1","compounds":"N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + pyruvate = L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphoenolpyruvate"}
{"X":45317,"RHEA_ID":53680,"compounds":"2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O"}
{"X":45318,"RHEA_ID":53681,"compounds":"2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 => 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O"}
{"X":45319,"RHEA_ID":43691,"compounds":"N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + pyruvate <=> L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphoenolpyruvate"}
{"X":45320,"RHEA_ID":43692,"DIRECTION":"UN","MASTER_ID":43692,"ec":"2.7.11.32","compounds":"ADP + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] = AMP + H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase]"}
{"X":45321,"RHEA_ID":43693,"compounds":"ADP + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] => AMP + H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase]"}
{"X":45322,"RHEA_ID":53685,"compounds":"2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 => 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O"}
{"X":45323,"RHEA_ID":43695,"DIRECTION":"BI","MASTER_ID":43692,"metacyc":"RXN-13757","compounds":"ADP + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] <=> AMP + H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase]"}
{"X":45324,"RHEA_ID":43696,"DIRECTION":"UN","MASTER_ID":43696,"ec":"2.7.4.27","compounds":"H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase] + phosphate = diphosphate + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]"}
{"X":45325,"RHEA_ID":53688,"compounds":"2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine"}
{"X":45326,"RHEA_ID":53689,"compounds":"2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O => (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine"}
{"X":45327,"RHEA_ID":43699,"DIRECTION":"BI","MASTER_ID":43696,"metacyc":"RXN-13756","compounds":"H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase] + phosphate <=> diphosphate + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]"}
{"X":45328,"RHEA_ID":43700,"DIRECTION":"UN","MASTER_ID":43700,"ec":"2.1.1.325","compounds":"(2E,6E)-farnesoate + S-adenosyl-L-methionine = methyl (2E,6E)-farnesoate + S-adenosyl-L-homocysteine"}
{"X":45329,"RHEA_ID":53692,"compounds":"2-(prostaglandin E2)-sn-glycero-3-phosphocholine + H2O = H(+) + prostaglandin E2 + sn-glycerol 3-phosphocholine"}
{"X":45330,"RHEA_ID":53693,"compounds":"2-(prostaglandin E2)-sn-glycero-3-phosphocholine + H2O => H(+) + prostaglandin E2 + sn-glycerol 3-phosphocholine"}
{"X":45331,"RHEA_ID":57028,"compounds":"FADH2 + N-methylnicotinate + O2 = (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FAD + H(+)"}
{"X":45332,"RHEA_ID":43704,"compounds":"ATP + H(+) + tetradecanoate = diphosphate + tetradecanoyl-AMP"}
{"X":45333,"RHEA_ID":53696,"compounds":"2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine"}
{"X":45334,"RHEA_ID":43706,"compounds":"diphosphate + tetradecanoyl-AMP => ATP + H(+) + tetradecanoate"}
{"X":45335,"RHEA_ID":43707,"compounds":"ATP + H(+) + tetradecanoate <=> diphosphate + tetradecanoyl-AMP"}
{"X":45336,"RHEA_ID":43708,"compounds":"ATP + H(+) + hexadecanoate = diphosphate + hexadecanoyl-AMP"}
{"X":45337,"RHEA_ID":53700,"compounds":"2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine"}
{"X":45338,"RHEA_ID":43710,"compounds":"diphosphate + hexadecanoyl-AMP => ATP + H(+) + hexadecanoate"}
{"X":45339,"RHEA_ID":57036,"DIRECTION":"UN","MASTER_ID":57036,"ec":"2.4.1.125","compounds":"[(1->6)-alpha-D-glucosyl](n) + sucrose = (1->3)-alpha-D-glucosyl-[(1->6)-alpha-D-glucosyl]n + D-fructose"}
{"X":45340,"RHEA_ID":43712,"compounds":"ATP + dodecanoate + H(+) = diphosphate + dodecanoyl-AMP"}
{"X":45341,"RHEA_ID":53704,"compounds":"2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine + H2O = H(+) + prostaglandin E2 + sn-glycero-3-phosphoethanolamine"}
{"X":45342,"RHEA_ID":43714,"compounds":"diphosphate + dodecanoyl-AMP => ATP + dodecanoate + H(+)"}
{"X":45343,"RHEA_ID":53706,"compounds":"H(+) + prostaglandin E2 + sn-glycero-3-phosphoethanolamine => 2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine + H2O"}
{"X":45344,"RHEA_ID":43716,"DIRECTION":"UN","MASTER_ID":43716,"ec":"2.7.7.89","compounds":"[glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + phosphate = [glutamine synthetase]-L-tyrosine + ADP"}
{"X":45345,"RHEA_ID":53708,"compounds":"(2E)-decenoyl-CoA + NADP(+) = (2E,4Z)-decadienoyl-CoA + H(+) + NADPH"}
{"X":45346,"RHEA_ID":43718,"compounds":"[glutamine synthetase]-L-tyrosine + ADP => [glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + phosphate"}
{"X":45347,"RHEA_ID":53710,"DIRECTION":"RL","MASTER_ID":53708,"ecocyc":"DIENOYLCOAREDUCT-RXN","metacyc":"DIENOYLCOAREDUCT-RXN","compounds":"(2E,4Z)-decadienoyl-CoA + H(+) + NADPH => (2E)-decenoyl-CoA + NADP(+)"}
{"X":45348,"RHEA_ID":43720,"DIRECTION":"UN","MASTER_ID":43720,"ec":"2.1.1.325","compounds":"juvenile hormone III carboxylate + S-adenosyl-L-methionine = juvenile hormone III + S-adenosyl-L-homocysteine"}
{"X":45349,"RHEA_ID":53712,"DIRECTION":"UN","MASTER_ID":53712,"ec":"4.99.1.8","compounds":"2 Fe(III)-heme b = beta-hematin"}
{"X":45350,"RHEA_ID":43722,"compounds":"juvenile hormone III + S-adenosyl-L-homocysteine => juvenile hormone III carboxylate + S-adenosyl-L-methionine"}
{"X":45351,"RHEA_ID":47033,"compounds":"AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA => 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]"}
{"X":45352,"RHEA_ID":43724,"DIRECTION":"UN","MASTER_ID":43724,"ec":"1.14.14.128","compounds":"(2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + juvenile hormone III carboxylate + oxidized [NADPH--hemoprotein reductase]"}
{"X":45353,"RHEA_ID":53716,"DIRECTION":"UN","MASTER_ID":53716,"ec":"2.7.7.99","compounds":"H(+) + N-acetyl-alpha-D-muramate 1-phosphate + UDP = phosphate + UDP-N-acetyl-alpha-D-muramate"}
{"X":45354,"RHEA_ID":43726,"compounds":"H(+) + H2O + juvenile hormone III carboxylate + oxidized [NADPH--hemoprotein reductase] => (2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":45355,"RHEA_ID":57052,"compounds":"3-oxo-isoapionate + H(+) = CO2 + L-erythrulose"}
{"X":45356,"RHEA_ID":43728,"DIRECTION":"UN","MASTER_ID":43728,"ec":"1.14.14.127","compounds":"methyl (2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + juvenile hormone III + oxidized [NADPH--hemoprotein reductase]"}
{"X":45357,"RHEA_ID":57054,"compounds":"CO2 + L-erythrulose => 3-oxo-isoapionate + H(+)"}
{"X":45358,"RHEA_ID":43730,"compounds":"H(+) + H2O + juvenile hormone III + oxidized [NADPH--hemoprotein reductase] => methyl (2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":45359,"RHEA_ID":53722,"compounds":"ADP + H(+) + N-acetyl-alpha-D-muramate 1-phosphate => ATP + N-acetyl-D-muramate"}
{"X":45360,"RHEA_ID":47042,"compounds":"5-taurinomethyl-2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein] => 5-taurinomethyluridine(34) in tRNA + AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein]"}
{"X":45361,"RHEA_ID":47043,"DIRECTION":"BI","MASTER_ID":47040,"metacyc":"RXN-16821","compounds":"5-taurinomethyluridine(34) in tRNA + AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] <=> 5-taurinomethyl-2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]"}
{"X":45362,"RHEA_ID":43734,"compounds":"1,3-diacyl-sn-glycerol + a fatty acid + H(+) => a triacyl-sn-glycerol + H2O"}
{"X":45363,"RHEA_ID":43735,"compounds":"a triacyl-sn-glycerol + H2O <=> 1,3-diacyl-sn-glycerol + a fatty acid + H(+)"}
{"X":45364,"RHEA_ID":43736,"DIRECTION":"UN","MASTER_ID":43736,"ec":"2.1.1.266","compounds":"adenosine(2030) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(2030) in 23S rRNA + S-adenosyl-L-homocysteine"}
{"X":45365,"RHEA_ID":53728,"DIRECTION":"UN","MASTER_ID":53728,"ec":"3.1.3.105","compounds":"H2O + N-acetyl-D-muramate 6-phosphate = N-acetyl-D-muramate + phosphate"}
{"X":45366,"RHEA_ID":43738,"compounds":"H(+) + N(6)-methyladenosine(2030) in 23S rRNA + S-adenosyl-L-homocysteine => adenosine(2030) in 23S rRNA + S-adenosyl-L-methionine"}
{"X":45367,"RHEA_ID":43739,"compounds":"adenosine(2030) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine(2030) in 23S rRNA + S-adenosyl-L-homocysteine"}
{"X":45368,"RHEA_ID":43740,"compounds":"ATP + CoA + hexanoate = AMP + diphosphate + hexanoyl-CoA"}
{"X":45369,"RHEA_ID":47051,"compounds":"a quinone + shikimate <=> 3-dehydroshikimate + a quinol"}
{"X":45370,"RHEA_ID":43742,"compounds":"AMP + diphosphate + hexanoyl-CoA => ATP + CoA + hexanoate"}
{"X":45371,"RHEA_ID":43743,"compounds":"ATP + CoA + hexanoate <=> AMP + diphosphate + hexanoyl-CoA"}
{"X":45372,"RHEA_ID":43744,"DIRECTION":"UN","MASTER_ID":43744,"ec":"6.3.4.19","compounds":"ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)"}
{"X":45373,"RHEA_ID":43745,"DIRECTION":"LR","MASTER_ID":43744,"ecocyc":"RXN-1961","metacyc":"RXN-1961","compounds":"ATP + cytidine(34) in tRNA(Ile2) + L-lysine => AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)"}
{"X":45374,"RHEA_ID":43746,"compounds":"AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2) => ATP + cytidine(34) in tRNA(Ile2) + L-lysine"}
{"X":45375,"RHEA_ID":53738,"compounds":"a halide anion + catechol + CO2 + NAD(+) => a 2-halobenzoate + H(+) + NADH + O2"}
{"X":45376,"RHEA_ID":47058,"compounds":"4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O => 4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2"}
{"X":45377,"RHEA_ID":57074,"compounds":"CO2 + L-erythrulose 1-phosphate => 3-oxo-isoapionate 4-phosphate + H(+)"}
{"X":45378,"RHEA_ID":43750,"compounds":"AMP + diphosphate + hexacosanoyl-CoA => ATP + CoA + hexacosanoate"}
{"X":45379,"RHEA_ID":43751,"compounds":"ATP + CoA + hexacosanoate <=> AMP + diphosphate + hexacosanoyl-CoA"}
{"X":45380,"RHEA_ID":43752,"DIRECTION":"UN","MASTER_ID":43752,"ec":"2.3.1.267","compounds":"acetyl-CoA + N-terminal L-alanyl-[ribosomal protein uS5] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein uS5]"}
{"X":45381,"RHEA_ID":57078,"compounds":"3-phosphoglycerate + glycolate + H(+) => 3-oxo-isoapionate 4-phosphate + H2O"}
{"X":45382,"RHEA_ID":43754,"compounds":"CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein uS5] => acetyl-CoA + N-terminal L-alanyl-[ribosomal protein uS5]"}
{"X":45383,"RHEA_ID":43755,"compounds":"acetyl-CoA + N-terminal L-alanyl-[ribosomal protein uS5] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein uS5]"}
{"X":45384,"RHEA_ID":43756,"DIRECTION":"UN","MASTER_ID":43756,"ec":"2.3.1.266","compounds":"acetyl-CoA + N-terminal L-alanyl-[ribosomal protein bS18] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein bS18]"}
{"X":45385,"RHEA_ID":57082,"compounds":"1-deoxy-D-xylulose 5-phosphate + S-(methylsulfanyl)glutathione => 1-methylsulfanyl-D-xylulose 5-phosphate + glutathione"}
{"X":45386,"RHEA_ID":43758,"compounds":"CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein bS18] => acetyl-CoA + N-terminal L-alanyl-[ribosomal protein bS18]"}
{"X":45387,"RHEA_ID":43759,"compounds":"acetyl-CoA + N-terminal L-alanyl-[ribosomal protein bS18] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein bS18]"}
{"X":45388,"RHEA_ID":43760,"compounds":"acetyl-CoA + N-terminal L-seryl-[ribosomal protein bL12] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[ribosomal protein bL12]"}
{"X":45389,"RHEA_ID":57086,"compounds":"a fatty acid + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O"}
{"X":45390,"RHEA_ID":43762,"compounds":"CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[ribosomal protein bL12] => acetyl-CoA + N-terminal L-seryl-[ribosomal protein bL12]"}
{"X":45391,"RHEA_ID":43763,"compounds":"acetyl-CoA + N-terminal L-seryl-[ribosomal protein bL12] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[ribosomal protein bL12]"}
{"X":45392,"RHEA_ID":43764,"compounds":"ATP + chenodeoxycholate + CoA = AMP + chenodeoxycholoyl-CoA + diphosphate"}
{"X":45393,"RHEA_ID":57090,"compounds":"3-beta-D-galactosyl-sn-glycerol + a fatty acid + H(+) => an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O"}
{"X":45394,"RHEA_ID":43766,"compounds":"AMP + chenodeoxycholoyl-CoA + diphosphate => ATP + chenodeoxycholate + CoA"}
{"X":45395,"RHEA_ID":43767,"compounds":"ATP + chenodeoxycholate + CoA <=> AMP + chenodeoxycholoyl-CoA + diphosphate"}
{"X":45396,"RHEA_ID":43768,"compounds":"an alkylamine + L-glutaminyl-[protein] = N(5)-alkyl-L-glutaminyl-[protein] + NH4(+)"}
{"X":45397,"RHEA_ID":53760,"compounds":"allocholate + deoxycholoyl-CoA = allocholoyl-CoA + deoxycholate"}
{"X":45398,"RHEA_ID":43770,"compounds":"N(5)-alkyl-L-glutaminyl-[protein] + NH4(+) => an alkylamine + L-glutaminyl-[protein]"}
{"X":45399,"RHEA_ID":43772,"DIRECTION":"UN","MASTER_ID":43772,"ec":"2.1.1.264","compounds":"guanosine(2069) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(2069) in 23S rRNA + S-adenosyl-L-homocysteine"}
{"X":45400,"RHEA_ID":47083,"compounds":"17beta-hydroxyestr-4-en-3-one + H(+) + NADPH <=> 17beta-hydroxy-5beta-estran-3-one + NADP(+)"}
{"X":45401,"RHEA_ID":43774,"compounds":"H(+) + N(2)-methylguanosine(2069) in 23S rRNA + S-adenosyl-L-homocysteine => guanosine(2069) in 23S rRNA + S-adenosyl-L-methionine"}
{"X":45402,"RHEA_ID":43775,"compounds":"guanosine(2069) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(2069) in 23S rRNA + S-adenosyl-L-homocysteine"}
{"X":45403,"RHEA_ID":43776,"compounds":"an N-(acyl)-sphingosylphosphocholine(in) = an N-(acyl)-sphingosylphosphocholine(out)"}
{"X":45404,"RHEA_ID":47087,"compounds":"4-methylsulfanyl-2-oxobutanoate + L-tyrosine <=> 3-(4-hydroxyphenyl)pyruvate + L-methionine"}
{"X":45405,"RHEA_ID":43778,"compounds":"an N-(acyl)-sphingosylphosphocholine(out) => an N-(acyl)-sphingosylphosphocholine(in)"}
{"X":45406,"RHEA_ID":43779,"compounds":"an N-(acyl)-sphingosylphosphocholine(in) <=> an N-(acyl)-sphingosylphosphocholine(out)"}
{"X":45407,"RHEA_ID":43780,"DIRECTION":"UN","MASTER_ID":43780,"ec":"1.3.8.5","compounds":"2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-2-methylbutenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":45408,"RHEA_ID":47091,"compounds":"(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + NAD(+) <=> 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH"}
{"X":45409,"RHEA_ID":43782,"compounds":"(2E)-2-methylbutenoyl-CoA + reduced [electron-transfer flavoprotein] => 2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":45410,"RHEA_ID":53774,"compounds":"chenodeoxycholoyl-CoA + lithocholate => chenodeoxycholate + lithocholoyl-CoA"}
{"X":45411,"RHEA_ID":57108,"compounds":"1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine"}
{"X":45412,"RHEA_ID":47095,"compounds":"(S)-2,3-dihydrodipicolinate + NADP(+) <=> dipicolinate + H(+) + NADPH"}
{"X":45413,"RHEA_ID":43786,"compounds":"H(+) + N(1)-methyladenosine(2142) in 25S rRNA + S-adenosyl-L-homocysteine => adenosine(2142) in 25S rRNA + S-adenosyl-L-methionine"}
{"X":45414,"RHEA_ID":53778,"compounds":"3-sulfinopropanoate + H(+) => 3-mercaptopropanoate + O2"}
{"X":45415,"RHEA_ID":43788,"DIRECTION":"UN","MASTER_ID":43788,"ec":"2.3.1.193","compounds":"acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O = ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + phosphate"}
{"X":45416,"RHEA_ID":53780,"compounds":"beta-muricholate + lithocholoyl-CoA = beta-muricholoyl-CoA + lithocholate"}
{"X":45417,"RHEA_ID":43790,"compounds":"ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + phosphate => acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O"}
{"X":45418,"RHEA_ID":43791,"compounds":"acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O <=> ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + phosphate"}
{"X":45419,"RHEA_ID":43792,"DIRECTION":"UN","MASTER_ID":43792,"ec":"2.1.1.287","compounds":"adenosine(645) in 25S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(645) in 25S rRNA + S-adenosyl-L-homocysteine"}
{"X":45420,"RHEA_ID":47103,"compounds":"choloyl-CoA + taurine <=> CoA + H(+) + taurocholate"}
{"X":45421,"RHEA_ID":43794,"compounds":"H(+) + N(1)-methyladenosine(645) in 25S rRNA + S-adenosyl-L-homocysteine => adenosine(645) in 25S rRNA + S-adenosyl-L-methionine"}
{"X":45422,"RHEA_ID":53786,"compounds":"beta-muricholoyl-CoA + deoxycholate => beta-muricholate + deoxycholoyl-CoA"}
{"X":45423,"RHEA_ID":43796,"compounds":"1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine = 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":45424,"RHEA_ID":53788,"compounds":"allodeoxycholoyl-CoA + beta-muricholate = allodeoxycholate + beta-muricholoyl-CoA"}
{"X":45425,"RHEA_ID":43798,"compounds":"1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine"}
{"X":45426,"RHEA_ID":43799,"compounds":"1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine <=> 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":45427,"RHEA_ID":43800,"compounds":"1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine = 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":45428,"RHEA_ID":47111,"compounds":"cholate + taurine <=> H2O + taurocholate"}
{"X":45429,"RHEA_ID":43802,"compounds":"1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine"}
{"X":45430,"RHEA_ID":43803,"compounds":"1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine <=> 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":45431,"RHEA_ID":60646,"compounds":"3alpha-sulfooxy-5alpha-androstan-17-one + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3alpha-hydroxy-5alpha-androstan-17-one"}
{"X":45432,"RHEA_ID":47115,"compounds":"chenodeoxycholate + glycine <=> glycochenodeoxycholate + H2O"}
{"X":45433,"RHEA_ID":43810,"compounds":"1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":45434,"RHEA_ID":43811,"compounds":"1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine"}
{"X":45435,"RHEA_ID":43812,"compounds":"1,2-dioctadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine"}
{"X":45436,"RHEA_ID":47119,"compounds":"eicosanoate + glycine <=> H2O + N-eicosanoylglycinate"}
{"X":45437,"RHEA_ID":43814,"compounds":"1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1,2-dioctadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":45438,"RHEA_ID":43815,"compounds":"1,2-dioctadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine"}
{"X":45439,"RHEA_ID":57136,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphoserine"}
{"X":45440,"RHEA_ID":47123,"compounds":"docosanoate + glycine <=> H2O + N-docosanoylglycine"}
{"X":45441,"RHEA_ID":43818,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":45442,"RHEA_ID":43819,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}
{"X":45443,"RHEA_ID":43820,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":45444,"RHEA_ID":47127,"compounds":"glycine + hexacosanoate <=> H2O + N-hexacosanoylglycine"}
{"X":45445,"RHEA_ID":43822,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":45446,"RHEA_ID":43823,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":45447,"RHEA_ID":50504,"DIRECTION":"UN","MASTER_ID":50504,"ec":"2.3.1.255","compounds":"acetyl-CoA + N-terminal L-seryl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[protein]"}
{"X":45448,"RHEA_ID":47131,"compounds":"ATP + CoA + deoxycholate <=> AMP + deoxycholoyl-CoA + diphosphate"}
{"X":45449,"RHEA_ID":43826,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphate => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":45450,"RHEA_ID":43827,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphate"}
{"X":45451,"RHEA_ID":43828,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)"}
{"X":45452,"RHEA_ID":47135,"compounds":"11-cis-retinal + H2O + NAD(+) <=> 11-cis-retinoate + 2 H(+) + NADH"}
{"X":45453,"RHEA_ID":43830,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":45454,"RHEA_ID":43831,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)"}
{"X":45455,"RHEA_ID":57152,"DIRECTION":"UN","MASTER_ID":57152,"ec":"1.14.11.63","compounds":"2-oxoglutarate + L-lysyl-[protein] + O2 = (3S)-3-hydroxy-L-lysyl-[protein] + CO2 + succinate"}
{"X":45456,"RHEA_ID":47139,"compounds":"ATP + CoA + lithocholate <=> AMP + diphosphate + lithocholoyl-CoA"}
{"X":45457,"RHEA_ID":43834,"compounds":"5-hydroxy-3-[(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate => 5-hydroxy-3-[(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA"}
{"X":45458,"RHEA_ID":43835,"compounds":"5-hydroxy-3-[(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA <=> 5-hydroxy-3-[(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate"}
{"X":45459,"RHEA_ID":43836,"compounds":"cholesterol + H(+) + NADPH + O2 = 26-hydroxycholesterol + H2O + NADP(+)"}
{"X":45460,"RHEA_ID":43838,"compounds":"26-hydroxycholesterol + H2O + NADP(+) => cholesterol + H(+) + NADPH + O2"}
{"X":45461,"RHEA_ID":43839,"compounds":"cholesterol + H(+) + NADPH + O2 <=> 26-hydroxycholesterol + H2O + NADP(+)"}
{"X":45462,"RHEA_ID":43840,"compounds":"26-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (3beta)-hydroxy-cholest-5-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":45463,"RHEA_ID":43842,"compounds":"(3beta)-hydroxy-cholest-5-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 26-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":45464,"RHEA_ID":43843,"compounds":"26-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (3beta)-hydroxy-cholest-5-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":45465,"RHEA_ID":60682,"compounds":"(+)-artemisinate + 2 H(+) + NADPH => (+)-artemisinic aldehyde + H2O + NADP(+)"}
{"X":45466,"RHEA_ID":57165,"compounds":"2-oxoglutarate + L-arginyl-[RCC1 domain-containing protein] + O2 => (3R)-3-hydroxy-L-arginyl-[RCC1 domain-containing protein] + CO2 + succinate"}
{"X":45467,"RHEA_ID":43846,"compounds":"(3beta)-hydroxy-cholest-5-en-26-oate + H2O + NADP(+) => (3beta)-hydroxy-cholest-5-en-26-al + NADPH + O2"}
{"X":45468,"RHEA_ID":43847,"compounds":"(3beta)-hydroxy-cholest-5-en-26-al + NADPH + O2 <=> (3beta)-hydroxy-cholest-5-en-26-oate + H2O + NADP(+)"}
{"X":45469,"RHEA_ID":50527,"compounds":"acetyl-CoA + N-terminal L-methionyl-L-isoleucyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-isoleucyl-[protein]"}
{"X":45470,"RHEA_ID":47155,"compounds":"2,5-dioxopentanoate + H2O + NAD(+) <=> 2-oxoglutarate + 2 H(+) + NADH"}
{"X":45471,"RHEA_ID":43850,"compounds":"[thioredoxin]-disulfide + arsenite + H2O => [thioredoxin]-dithiol + arsenate + H(+)"}
{"X":45472,"RHEA_ID":43851,"compounds":"[thioredoxin]-dithiol + arsenate + H(+) <=> [thioredoxin]-disulfide + arsenite + H2O"}
{"X":45473,"RHEA_ID":60690,"compounds":"(11R)-dihydroartemisinate + 2 H(+) + NADH => (11R)-dihydroartemisinic aldehyde + H2O + NAD(+)"}
{"X":45474,"RHEA_ID":57173,"compounds":"(S)-2-hydroxyglutarate + NAD(+) => 2-oxoglutarate + H(+) + NADH"}
{"X":45475,"RHEA_ID":43854,"compounds":"3-oxo-dotriacontanoyl-CoA + CO2 + CoA => H(+) + malonyl-CoA + triacontanoyl-CoA"}
{"X":45476,"RHEA_ID":43855,"compounds":"H(+) + malonyl-CoA + triacontanoyl-CoA <=> 3-oxo-dotriacontanoyl-CoA + CO2 + CoA"}
{"X":45477,"RHEA_ID":57176,"compounds":"L-arginyl-[protein] + methylglyoxal = N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein]"}
{"X":45478,"RHEA_ID":47163,"compounds":"4alpha-carboxyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+) <=> 4-methyl-5alpha-cholesta-8,24-dien-3-one + CO2 + NADH"}
{"X":45479,"RHEA_ID":43858,"compounds":"a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(out) => a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(in)"}
{"X":45480,"RHEA_ID":43859,"compounds":"a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(in) <=> a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(out)"}
{"X":45481,"RHEA_ID":57180,"compounds":"L-lysyl-[protein] + methylglyoxal = N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein]"}
{"X":45482,"RHEA_ID":47167,"compounds":"4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+) <=> CO2 + NADH + zymosterone"}
{"X":45483,"RHEA_ID":43862,"compounds":"1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(out) => 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(in)"}
{"X":45484,"RHEA_ID":43863,"compounds":"1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(in) <=> 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(out)"}
{"X":45485,"RHEA_ID":43864,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine(in) = 1-hexadecanoyl-sn-glycero-3-phosphocholine(out)"}
{"X":45486,"RHEA_ID":47171,"compounds":"4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NAD(+) <=> 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADH"}
{"X":45487,"RHEA_ID":43866,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine(out) => 1-hexadecanoyl-sn-glycero-3-phosphocholine(in)"}
{"X":45488,"RHEA_ID":43867,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine(in) <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine(out)"}
{"X":45489,"RHEA_ID":43868,"compounds":"a 1-acyl-sn-glycero-3-phosphoethanolamine(in) = a 1-acyl-sn-glycero-3-phosphoethanolamine(out)"}
{"X":45490,"RHEA_ID":53860,"compounds":"7beta-hydroxy-3,12-dioxo-5beta-cholan-24-oate + NADP(+) = dehydrocholate + H(+) + NADPH"}
{"X":45491,"RHEA_ID":43870,"compounds":"a 1-acyl-sn-glycero-3-phosphoethanolamine(out) => a 1-acyl-sn-glycero-3-phosphoethanolamine(in)"}
{"X":45492,"RHEA_ID":43871,"compounds":"a 1-acyl-sn-glycero-3-phosphoethanolamine(in) <=> a 1-acyl-sn-glycero-3-phosphoethanolamine(out)"}
{"X":45493,"RHEA_ID":50549,"compounds":"prostaglandin E1 => H2O + prostaglandin A1"}
{"X":45494,"RHEA_ID":47179,"compounds":"(2R)-hydroxybutanoyl-CoA <=> (2E)-butenoyl-CoA + H2O"}
{"X":45495,"RHEA_ID":43874,"compounds":"3-oxochol-4-en-22-oyl-CoA + AMP + diphosphate => 3-oxochol-4-en-22-oate + ATP + CoA"}
{"X":45496,"RHEA_ID":43875,"compounds":"3-oxochol-4-en-22-oate + ATP + CoA <=> 3-oxochol-4-en-22-oyl-CoA + AMP + diphosphate"}
{"X":45497,"RHEA_ID":47182,"compounds":"(25R)-7alpha,26-dihydroxycholest-4-en-3-one + H(+) + NADH => (25R)-cholest-5-en-3beta,7alpha,26-triol + NAD(+)"}
{"X":45498,"RHEA_ID":47183,"compounds":"(25R)-cholest-5-en-3beta,7alpha,26-triol + NAD(+) <=> (25R)-7alpha,26-dihydroxycholest-4-en-3-one + H(+) + NADH"}
{"X":45499,"RHEA_ID":43878,"compounds":"3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oyl-CoA + AMP + diphosphate => 3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oate + ATP + CoA"}
{"X":45500,"RHEA_ID":43879,"compounds":"3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oate + ATP + CoA <=> 3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oyl-CoA + AMP + diphosphate"}
{"X":45501,"RHEA_ID":57200,"compounds":"glyoxal + L-arginyl-[protein] = N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein]"}
{"X":45502,"RHEA_ID":47187,"compounds":"5alpha-cholesta-7,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + cholesta-5,7,24-trien-3beta-ol + 2 H2O"}
{"X":45503,"RHEA_ID":43882,"compounds":"3beta-hydroxy-5-cholestenoyl-CoA + AMP + diphosphate => 3beta-hydroxy-5-cholestenoate + ATP + CoA"}
{"X":45504,"RHEA_ID":43883,"compounds":"3beta-hydroxy-5-cholestenoate + ATP + CoA <=> 3beta-hydroxy-5-cholestenoyl-CoA + AMP + diphosphate"}
{"X":45505,"RHEA_ID":43884,"compounds":"3-oxochol-4-en-22-oyl-CoA + NAD(+) = 3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH"}
{"X":45506,"RHEA_ID":43886,"compounds":"3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH => 3-oxochol-4-en-22-oyl-CoA + NAD(+)"}
{"X":45507,"RHEA_ID":43887,"compounds":"3-oxochol-4-en-22-oyl-CoA + NAD(+) <=> 3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH"}
{"X":45508,"RHEA_ID":43888,"compounds":"[sulfur carrier]-H + [sulfur-carrier protein]-S-sulfanyl-L-cysteine = [sulfur carrier]-SH + [sulfur-carrier protein]-L-cysteine"}
{"X":45509,"RHEA_ID":57209,"compounds":"glyoxal + L-cysteinyl-[protein] => S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein]"}
{"X":45510,"RHEA_ID":43890,"compounds":"[sulfur carrier]-SH + [sulfur-carrier protein]-L-cysteine => [sulfur carrier]-H + [sulfur-carrier protein]-S-sulfanyl-L-cysteine"}
{"X":45511,"RHEA_ID":43892,"DIRECTION":"UN","MASTER_ID":43892,"ec":"2.8.1.7","compounds":"[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine"}
{"X":45512,"RHEA_ID":53885,"compounds":"CDP-alpha-D-glucose + D-glucose 6-phosphate => alpha,alpha-trehalose 6-phosphate + CDP + H(+)"}
{"X":45513,"RHEA_ID":57216,"compounds":"dGTP + glyoxal = N(2)-(1-hydroxy-2-oxoethyl)-dGTP"}
{"X":45514,"RHEA_ID":53888,"compounds":"D-glucose 6-phosphate + TDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + H(+) + TDP"}
{"X":45515,"RHEA_ID":43898,"compounds":"3beta,7alpha-dihydroxy-5alpha-androstan-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3beta-hydroxy-5alpha-androstan-17-one + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":45516,"RHEA_ID":53890,"compounds":"alpha,alpha-trehalose 6-phosphate + H(+) + TDP => D-glucose 6-phosphate + TDP-alpha-D-glucose"}
{"X":45517,"RHEA_ID":43900,"DIRECTION":"UN","MASTER_ID":43900,"ec":"3.2.1.161","compounds":"dalpatein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O = beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalpatein + H(+)"}
{"X":45518,"RHEA_ID":47207,"compounds":"estrone + O2 + reduced [NADPH--hemoprotein reductase] <=> 16alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":45519,"RHEA_ID":53893,"compounds":"an S-prenyl-L-cysteine + H2O + O2 => a prenal + H2O2 + L-cysteine"}
{"X":45520,"RHEA_ID":43903,"compounds":"dalpatein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O <=> beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalpatein + H(+)"}
{"X":45521,"RHEA_ID":47210,"compounds":"2-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => estrone + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":45522,"RHEA_ID":53896,"DIRECTION":"UN","MASTER_ID":53896,"ec":"2.4.99.7","compounds":"an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+)"}
{"X":45523,"RHEA_ID":53897,"DIRECTION":"LR","MASTER_ID":53896,"metacyc":"2.4.99.7-RXN","compounds":"an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate => an N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+)"}
{"X":45524,"RHEA_ID":43907,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol <=> all-trans-retinyl hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":45525,"RHEA_ID":43908,"compounds":"beta-D-galactosyl-(1<->1)-sphing-4-enine + H2O = D-galactose + sphing-4-enine"}
{"X":45526,"RHEA_ID":53900,"DIRECTION":"UN","MASTER_ID":53900,"ec":"2.7.11.18","compounds":"[myosin light chain]-L-threonine + ATP = [myosin light chain]-O-phospho-L-threonine + ADP + H(+)"}
{"X":45527,"RHEA_ID":53901,"compounds":"[myosin light chain]-L-threonine + ATP => [myosin light chain]-O-phospho-L-threonine + ADP + H(+)"}
{"X":45528,"RHEA_ID":43911,"compounds":"beta-D-galactosyl-(1<->1)-sphing-4-enine + H2O <=> D-galactose + sphing-4-enine"}
{"X":45529,"RHEA_ID":43912,"compounds":"cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (25R)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":45530,"RHEA_ID":57233,"compounds":"GDP + methylglyoxal => N(2)-(1-hydroxy-2-oxopropyl)-GDP"}
{"X":45531,"RHEA_ID":53905,"compounds":"[tau protein]-L-threonine + ATP => [tau protein]-O-phospho-L-threonine + ADP + H(+)"}
{"X":45532,"RHEA_ID":53906,"compounds":"[tau protein]-O-phospho-L-threonine + ADP + H(+) => [tau protein]-L-threonine + ATP"}
{"X":45533,"RHEA_ID":43916,"compounds":"(25R)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (25R)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":45534,"RHEA_ID":57237,"compounds":"GMP + methylglyoxal => N(2)-(1-hydroxy-2-oxopropyl)-GMP"}
{"X":45535,"RHEA_ID":43918,"compounds":"(25R)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (25R)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":45536,"RHEA_ID":53910,"compounds":"CoA + H(+) + N(6)-(2E)-butenoyl-L-lysyl-[protein] => (2E)-butenoyl-CoA + L-lysyl-[protein]"}
{"X":45537,"RHEA_ID":43920,"compounds":"(25R)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (25R)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":45538,"RHEA_ID":57241,"compounds":"glyoxal + GMP => N(2)-(1-hydroxy-2-oxoethyl)-GMP"}
{"X":45539,"RHEA_ID":53913,"compounds":"butanoyl-CoA + L-lysyl-[protein] => CoA + H(+) + N(6)-butanoyl-L-lysyl-[protein]"}
{"X":45540,"RHEA_ID":53914,"compounds":"CoA + H(+) + N(6)-butanoyl-L-lysyl-[protein] => butanoyl-CoA + L-lysyl-[protein]"}
{"X":45541,"RHEA_ID":43924,"compounds":"NAD(+) + pregnenolone = H(+) + NADH + pregn-5-ene-3,20-dione"}
{"X":45542,"RHEA_ID":57245,"compounds":"H2O + N(2)-(1-hydroxy-2-oxopropyl)-dGTP => dGTP + H(+) + lactate"}
{"X":45543,"RHEA_ID":53917,"compounds":"an acyl-CoA + L-lysyl-[protein] => CoA + H(+) + N(6)-acyl-L-lysyl-[protein]"}
{"X":45544,"RHEA_ID":43927,"compounds":"NAD(+) + pregnenolone <=> H(+) + NADH + pregn-5-ene-3,20-dione"}
{"X":45545,"RHEA_ID":43928,"compounds":"pregn-5-ene-3,20-dione = progesterone"}
{"X":45546,"RHEA_ID":53920,"DIRECTION":"UN","MASTER_ID":53920,"ec":"2.7.11.8","compounds":"[Fas-activated protein]-L-threonine + ATP = [Fas-activated protein]-O-phospho-L-threonine + ADP + H(+)"}
{"X":45547,"RHEA_ID":53921,"compounds":"[Fas-activated protein]-L-threonine + ATP => [Fas-activated protein]-O-phospho-L-threonine + ADP + H(+)"}
{"X":45548,"RHEA_ID":43931,"compounds":"pregn-5-ene-3,20-dione <=> progesterone"}
{"X":45549,"RHEA_ID":47238,"compounds":"(2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein] => eicosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":45550,"RHEA_ID":53924,"DIRECTION":"UN","MASTER_ID":53924,"ec":"2.1.1.49","compounds":"a secondary amine + S-adenosyl-L-methionine = a methylated secondary amine + H(+) + S-adenosyl-L-homocysteine"}
{"X":45551,"RHEA_ID":53925,"DIRECTION":"LR","MASTER_ID":53924,"metacyc":"AMINE-N-METHYLTRANSFERASE-RXN","compounds":"a secondary amine + S-adenosyl-L-methionine => a methylated secondary amine + H(+) + S-adenosyl-L-homocysteine"}
{"X":45552,"RHEA_ID":53926,"compounds":"a methylated secondary amine + H(+) + S-adenosyl-L-homocysteine => a secondary amine + S-adenosyl-L-methionine"}
{"X":45553,"RHEA_ID":47242,"compounds":"(2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + octadecanoyl-CoA + oxidized [electron-transfer flavoprotein]"}
{"X":45554,"RHEA_ID":53928,"DIRECTION":"UN","MASTER_ID":53928,"ec":"2.1.1.49","compounds":"a tertiary amine + S-adenosyl-L-methionine = a methylated tertiary amine + H(+) + S-adenosyl-L-homocysteine"}
{"X":45555,"RHEA_ID":53929,"DIRECTION":"LR","MASTER_ID":53928,"metacyc":"AMINE-N-METHYLTRANSFERASE-RXN","compounds":"a tertiary amine + S-adenosyl-L-methionine => a methylated tertiary amine + H(+) + S-adenosyl-L-homocysteine"}
{"X":45556,"RHEA_ID":43939,"compounds":"androst-5-ene-3,17-dione <=> androst-4-ene-3,17-dione"}
{"X":45557,"RHEA_ID":43952,"compounds":"3,7,11,15-tetramethylhexadecanoate + H(+) + NADPH + O2 = H2O + NADP(+) + omega-hydroxy-3,7,11,15-tetramethyl-hexadecanoate"}
{"X":45558,"RHEA_ID":53932,"compounds":"O2 + prostaglandin I2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-prostaglandin I2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":45559,"RHEA_ID":53933,"compounds":"O2 + prostaglandin I2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxy-prostaglandin I2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":45560,"RHEA_ID":43955,"compounds":"3,7,11,15-tetramethylhexadecanoate + H(+) + NADPH + O2 <=> H2O + NADP(+) + omega-hydroxy-3,7,11,15-tetramethyl-hexadecanoate"}
{"X":45561,"RHEA_ID":43956,"compounds":"15-methylhexadecanoate + H(+) + NADPH + O2 = H2O + NADP(+) + omega-hydroxy-15-methyl-hexadecanoate"}
{"X":45562,"RHEA_ID":53936,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2 = 19-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":45563,"RHEA_ID":53937,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2 => 19-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":45564,"RHEA_ID":43959,"compounds":"15-methylhexadecanoate + H(+) + NADPH + O2 <=> H2O + NADP(+) + omega-hydroxy-15-methyl-hexadecanoate"}
{"X":45565,"RHEA_ID":43960,"compounds":"a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA = a 1-acyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}
{"X":45566,"RHEA_ID":43961,"compounds":"a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA => a 1-acyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}
{"X":45567,"RHEA_ID":53941,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2 => 18-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":45568,"RHEA_ID":43963,"compounds":"a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA <=> a 1-acyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}
{"X":45569,"RHEA_ID":43964,"compounds":"a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA = 1-octadecanoyl-2-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}
{"X":45570,"RHEA_ID":53944,"DIRECTION":"UN","MASTER_ID":53944,"ec":"1.3.1.105","compounds":"2-ethyl-4-hydroxy-5-methyl-3(2H)-furanone + NADP(+) = (2E)-2-ethylidene-4-hydroxy-5-methylfuran-3(2H)-one + H(+) + NADPH"}
{"X":45571,"RHEA_ID":53945,"compounds":"2-ethyl-4-hydroxy-5-methyl-3(2H)-furanone + NADP(+) => (2E)-2-ethylidene-4-hydroxy-5-methylfuran-3(2H)-one + H(+) + NADPH"}
{"X":45572,"RHEA_ID":43967,"compounds":"a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA <=> 1-octadecanoyl-2-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA"}
{"X":45573,"RHEA_ID":43968,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate"}
{"X":45574,"RHEA_ID":53948,"DIRECTION":"UN","MASTER_ID":53948,"ec":"6.2.1.39","compounds":"ATP + holo-[BtrI ACP] + L-glutamate = ADP + gamma-L-glutamyl-[BtrI ACP] + phosphate"}
{"X":45575,"RHEA_ID":47264,"compounds":"2,6,10,14-tetramethylpentadecanoate + ATP + CoA = AMP + diphosphate + pristanoyl-CoA"}
{"X":45576,"RHEA_ID":43971,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate"}
{"X":45577,"RHEA_ID":43972,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = H(+) + hexadecanoate + hexadecanoyl-glycero-3-phospho-(1D-myo-inositol)"}
{"X":45578,"RHEA_ID":53952,"DIRECTION":"UN","MASTER_ID":53952,"ec":"6.2.1.39","compounds":"4-aminobutanoyl-[BtrI ACP] + ATP + L-glutamate = 4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + ADP + H(+) + phosphate"}
{"X":45579,"RHEA_ID":47268,"compounds":"bacterioruberin = H2O + monoanhydrobacterioruberin"}
{"X":45580,"RHEA_ID":43975,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> H(+) + hexadecanoate + hexadecanoyl-glycero-3-phospho-(1D-myo-inositol)"}
{"X":45581,"RHEA_ID":43976,"compounds":"H(+) + hexadecanoate + NADPH + O2 = 14-hydroxyhexadecanoate + H2O + NADP(+)"}
{"X":45582,"RHEA_ID":53956,"DIRECTION":"UN","MASTER_ID":53956,"ec":"4.1.1.95","compounds":"gamma-L-glutamyl-[BtrI ACP] + H(+) = 4-aminobutanoyl-[BtrI ACP] + CO2"}
{"X":45583,"RHEA_ID":47272,"compounds":"monoanhydrobacterioruberin = bisanhydrobacterioruberin + H2O"}
{"X":45584,"RHEA_ID":43979,"compounds":"H(+) + hexadecanoate + NADPH + O2 <=> 14-hydroxyhexadecanoate + H2O + NADP(+)"}
{"X":45585,"RHEA_ID":43980,"compounds":"H(+) + hexadecanoate + NADPH + O2 = 15-hydroxyhexadecanoate + H2O + NADP(+)"}
{"X":45586,"RHEA_ID":53960,"DIRECTION":"UN","MASTER_ID":53960,"ec":"1.14.14.13","compounds":"4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + FMNH2 + O2 = 4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + FMN + H(+) + H2O"}
{"X":45587,"RHEA_ID":53961,"DIRECTION":"LR","MASTER_ID":53960,"metacyc":"RXN-13216","compounds":"4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + FMNH2 + O2 => 4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + FMN + H(+) + H2O"}
{"X":45588,"RHEA_ID":43983,"compounds":"H(+) + hexadecanoate + NADPH + O2 <=> 15-hydroxyhexadecanoate + H2O + NADP(+)"}
{"X":45589,"RHEA_ID":43984,"compounds":"(2E,6E)-farnesol + H(+) + NADPH + O2 = (2E,6E)-omega-hydroxy-farnesol + H2O + NADP(+)"}
{"X":45590,"RHEA_ID":53964,"DIRECTION":"UN","MASTER_ID":53964,"ec":"2.3.2.19","compounds":"4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + ribostamycin = gamma-L-glutamyl-butirosin B + H(+) + holo-[BtrI ACP]"}
{"X":45591,"RHEA_ID":47280,"compounds":"17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":45592,"RHEA_ID":43987,"compounds":"(2E,6E)-farnesol + H(+) + NADPH + O2 <=> (2E,6E)-omega-hydroxy-farnesol + H2O + NADP(+)"}
{"X":45593,"RHEA_ID":43988,"compounds":"(2E,6E)-farnesyl diphosphate + H(+) + NADPH + O2 = (2E,6E)-omega-hydroxy-farnesyl diphosphate + H2O + NADP(+)"}
{"X":45594,"RHEA_ID":53968,"compounds":"apo-[BtrI ACP] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[BtrI ACP]"}
{"X":45595,"RHEA_ID":53969,"compounds":"apo-[BtrI ACP] + CoA => adenosine 3',5'-bisphosphate + H(+) + holo-[BtrI ACP]"}
{"X":45596,"RHEA_ID":43991,"compounds":"(2E,6E)-farnesyl diphosphate + H(+) + NADPH + O2 <=> (2E,6E)-omega-hydroxy-farnesyl diphosphate + H2O + NADP(+)"}
{"X":45597,"RHEA_ID":43992,"compounds":"(2E,6E,10E)-geranylgeraniol + H(+) + NADPH + O2 = 16-hydroxy-(2E,6E,10E)-geranylgeraniol + H2O + NADP(+)"}
{"X":45598,"RHEA_ID":53972,"compounds":"(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = (8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate"}
{"X":45599,"RHEA_ID":47288,"compounds":"17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":45600,"RHEA_ID":43995,"compounds":"(2E,6E,10E)-geranylgeraniol + H(+) + NADPH + O2 <=> 16-hydroxy-(2E,6E,10E)-geranylgeraniol + H2O + NADP(+)"}
{"X":45601,"RHEA_ID":43996,"compounds":"2-oxoglutarate + 3-methyl fatty acyl-CoA + O2 = 2-hydroxy-3-methyl fatty acyl-CoA + CO2 + succinate"}
{"X":45602,"RHEA_ID":53976,"compounds":"(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = (14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate"}
{"X":45603,"RHEA_ID":53977,"compounds":"(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O => (14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate"}
{"X":45604,"RHEA_ID":43999,"compounds":"2-oxoglutarate + 3-methyl fatty acyl-CoA + O2 <=> 2-hydroxy-3-methyl fatty acyl-CoA + CO2 + succinate"}
{"X":45605,"RHEA_ID":44000,"compounds":"2-oxoglutarate + 3-methylhexadecanoyl-CoA + O2 = 2-hydroxy-3-methylhexadecanoyl-CoA + CO2 + succinate"}
{"X":45606,"RHEA_ID":53980,"compounds":"(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = (11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate"}
{"X":45607,"RHEA_ID":47296,"compounds":"dodecanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":45608,"RHEA_ID":44003,"compounds":"2-oxoglutarate + 3-methylhexadecanoyl-CoA + O2 <=> 2-hydroxy-3-methylhexadecanoyl-CoA + CO2 + succinate"}
{"X":45609,"RHEA_ID":44004,"compounds":"3-methyl fatty acid + ATP + CoA = 3-methyl fatty acyl-CoA + AMP + diphosphate"}
{"X":45610,"RHEA_ID":53984,"compounds":"(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = (11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate"}
{"X":45611,"RHEA_ID":44006,"compounds":"3-methyl fatty acyl-CoA + AMP + diphosphate => 3-methyl fatty acid + ATP + CoA"}
{"X":45612,"RHEA_ID":53986,"compounds":"(11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate => (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O"}
{"X":45613,"RHEA_ID":44008,"compounds":"2-methyl-branched fatty aldehyde + H2O + NAD(+) = 2-methyl fatty acid + 2 H(+) + NADH"}
{"X":45614,"RHEA_ID":53988,"DIRECTION":"UN","MASTER_ID":53988,"ec":"3.1.3.53","compounds":"[myosin light chain]-O-phospho-L-threonine + H2O = [myosin light chain]-L-threonine + phosphate"}
{"X":45615,"RHEA_ID":53989,"compounds":"[myosin light chain]-O-phospho-L-threonine + H2O => [myosin light chain]-L-threonine + phosphate"}
{"X":45616,"RHEA_ID":44011,"compounds":"2-methyl-branched fatty aldehyde + H2O + NAD(+) <=> 2-methyl fatty acid + 2 H(+) + NADH"}
{"X":45617,"RHEA_ID":44012,"DIRECTION":"UN","MASTER_ID":44012,"ec":"2.3.1.242","compounds":"(9Z)-hexadecenoyl-[ACP] + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA = (9Z)-hexadecenoyl-(Kdo)2-lipid IVA + holo-[ACP]"}
{"X":45618,"RHEA_ID":53992,"compounds":"(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = (14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate"}
{"X":45619,"RHEA_ID":44014,"compounds":"(9Z)-hexadecenoyl-(Kdo)2-lipid IVA + holo-[ACP] => (9Z)-hexadecenoyl-[ACP] + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA"}
{"X":45620,"RHEA_ID":53994,"compounds":"(14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate => (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O"}
{"X":45621,"RHEA_ID":44016,"compounds":"2,6,10,14-tetramethylpentadecanal + H2O + NAD(+) = 2,6,10,14-tetramethylpentadecanoate + 2 H(+) + NADH"}
{"X":45622,"RHEA_ID":44017,"compounds":"2,6,10,14-tetramethylpentadecanal + H2O + NAD(+) => 2,6,10,14-tetramethylpentadecanoate + 2 H(+) + NADH"}
{"X":45623,"RHEA_ID":44018,"compounds":"2,6,10,14-tetramethylpentadecanoate + 2 H(+) + NADH => 2,6,10,14-tetramethylpentadecanal + H2O + NAD(+)"}
{"X":45624,"RHEA_ID":57327,"compounds":"acetyl-CoA + N-terminal L-glutamyl-L-glutamyl-L-glutamyl-[protein] <=> CoA + H(+) + N-terminal N-acetyl-L-glutamyl-L-glutamyl-L-glutamyl-[protein]"}
{"X":45625,"RHEA_ID":44020,"compounds":"H2O + NAD(+) + octadecanal = 2 H(+) + NADH + octadecanoate"}
{"X":45626,"RHEA_ID":47315,"compounds":"estrone + O2 + reduced [NADPH--hemoprotein reductase] <=> 15alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":45627,"RHEA_ID":44022,"compounds":"2 H(+) + NADH + octadecanoate => H2O + NAD(+) + octadecanal"}
{"X":45628,"RHEA_ID":54002,"compounds":"(11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate => (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O"}
{"X":45629,"RHEA_ID":54003,"compounds":"(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O <=> (11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate"}
{"X":45630,"RHEA_ID":44025,"compounds":"(3R)-hydroxydodecanoyl-CoA => (2E)-dodecenoyl-CoA + H2O"}
{"X":45631,"RHEA_ID":44026,"compounds":"(2E)-dodecenoyl-CoA + H2O => (3R)-hydroxydodecanoyl-CoA"}
{"X":45632,"RHEA_ID":44027,"compounds":"(3R)-hydroxydodecanoyl-CoA <=> (2E)-dodecenoyl-CoA + H2O"}
{"X":45633,"RHEA_ID":54007,"compounds":"(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O <=> (11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate"}
{"X":45634,"RHEA_ID":44030,"compounds":"5-dehydro-4-deoxy-D-glucarate + H2O => L-altrarate"}
{"X":45635,"RHEA_ID":54010,"compounds":"(8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate => (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O"}
{"X":45636,"RHEA_ID":47326,"compounds":"3-oxo-3-phenylpropanoate + L-alanine => (S)-3-amino-3-phenylpropanoate + pyruvate"}
{"X":45637,"RHEA_ID":47327,"compounds":"(S)-3-amino-3-phenylpropanoate + pyruvate <=> 3-oxo-3-phenylpropanoate + L-alanine"}
{"X":45638,"RHEA_ID":44034,"compounds":"9,10-dihydroxy-(12Z)-octadecenoate => 9,10-epoxy-(12Z)-octadecenoate + H2O"}
{"X":45639,"RHEA_ID":54014,"compounds":"(8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate => (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O"}
{"X":45640,"RHEA_ID":44036,"compounds":"12,13-epoxy-(9Z)-octadecenoate + H2O = 12,13-dihydroxy-(9Z)-octadecenoate"}
{"X":45641,"RHEA_ID":47331,"compounds":"1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O <=> (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+)"}
{"X":45642,"RHEA_ID":44038,"compounds":"12,13-dihydroxy-(9Z)-octadecenoate => 12,13-epoxy-(9Z)-octadecenoate + H2O"}
{"X":45643,"RHEA_ID":54018,"compounds":"(8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate => (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O"}
{"X":45644,"RHEA_ID":54019,"compounds":"(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O <=> (8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate"}
{"X":45645,"RHEA_ID":47335,"compounds":"17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 16alpha,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":45646,"RHEA_ID":44042,"compounds":"14,15-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate => 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O"}
{"X":45647,"RHEA_ID":47337,"compounds":"17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 16beta,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":45648,"RHEA_ID":54023,"compounds":"L-lysyl-[protein] + propanoyl-CoA <=> CoA + H(+) + N(6)-propanoyl-L-lysyl-[protein]"}
{"X":45649,"RHEA_ID":47339,"compounds":"17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 16beta,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":45650,"RHEA_ID":44046,"compounds":"11,12-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate => 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O"}
{"X":45651,"RHEA_ID":54026,"compounds":"(3S)-3-hydroxy-L-histidyl-[ribosomal protein uL15] + CO2 + succinate => 2-oxoglutarate + L-histidyl-[ribosomal protein uL15] + O2"}
{"X":45652,"RHEA_ID":54027,"compounds":"2-oxoglutarate + L-histidyl-[ribosomal protein uL15] + O2 <=> (3S)-3-hydroxy-L-histidyl-[ribosomal protein uL15] + CO2 + succinate"}
{"X":45653,"RHEA_ID":44049,"compounds":"8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O => 8,9-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate"}
{"X":45654,"RHEA_ID":44050,"compounds":"8,9-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate => 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O"}
{"X":45655,"RHEA_ID":57363,"compounds":"H2O + NADH <=> (6R)-NADHX"}
{"X":45656,"RHEA_ID":54031,"compounds":"a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> a Delta(14) steroid + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}
{"X":45657,"RHEA_ID":47347,"compounds":"3beta-hydroxycholest-5-en-7-one + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta,26-dihydroxycholest-5-en-7-one + H2O + 2 oxidized [adrenodoxin]"}
{"X":45658,"RHEA_ID":44054,"compounds":"2-O-hexadecanoyl-alpha,alpha-trehalose + CoA => alpha,alpha-trehalose + hexadecanoyl-CoA"}
{"X":45659,"RHEA_ID":44055,"compounds":"alpha,alpha-trehalose + hexadecanoyl-CoA <=> 2-O-hexadecanoyl-alpha,alpha-trehalose + CoA"}
{"X":45660,"RHEA_ID":47350,"compounds":"an aliphatic alcohol + butanoate + H(+) => butanoate ester + H2O"}
{"X":45661,"RHEA_ID":47351,"compounds":"butanoate ester + H2O <=> an aliphatic alcohol + butanoate + H(+)"}
{"X":45662,"RHEA_ID":44058,"compounds":"2-O,3-O-dihexadecanoyl-alpha,alpha-trehalose + CoA => 2-O-hexadecanoyl-alpha,alpha-trehalose + hexadecanoyl-CoA"}
{"X":45663,"RHEA_ID":44059,"compounds":"2-O-hexadecanoyl-alpha,alpha-trehalose + hexadecanoyl-CoA <=> 2-O,3-O-dihexadecanoyl-alpha,alpha-trehalose + CoA"}
{"X":45664,"RHEA_ID":47354,"compounds":"an aliphatic alcohol + H(+) + hexanoate => H2O + hexanoate ester"}
{"X":45665,"RHEA_ID":47355,"compounds":"H2O + hexanoate ester <=> an aliphatic alcohol + H(+) + hexanoate"}
{"X":45666,"RHEA_ID":44062,"compounds":"2-O-sulfo-2'-O-hexadecanoyl-alpha,alpha-trehalose + CoA => 2-O-sulfo-alpha,alpha-trehalose + hexadecanoyl-CoA"}
{"X":45667,"RHEA_ID":44063,"compounds":"2-O-sulfo-alpha,alpha-trehalose + hexadecanoyl-CoA <=> 2-O-sulfo-2'-O-hexadecanoyl-alpha,alpha-trehalose + CoA"}
{"X":45668,"RHEA_ID":47358,"compounds":"an aliphatic alcohol + H(+) + octanoate => H2O + octanoate ester"}
{"X":45669,"RHEA_ID":47359,"compounds":"H2O + octanoate ester <=> an aliphatic alcohol + H(+) + octanoate"}
{"X":45670,"RHEA_ID":44066,"compounds":"CoA + octyl hexadecanoyl => hexadecanoyl-CoA + octan-1-ol"}
{"X":45671,"RHEA_ID":47361,"compounds":"decanoate ester + H2O => an aliphatic alcohol + decanoate + H(+)"}
{"X":45672,"RHEA_ID":47362,"compounds":"an aliphatic alcohol + decanoate + H(+) => decanoate ester + H2O"}
{"X":45673,"RHEA_ID":54048,"DIRECTION":"UN","MASTER_ID":54048,"ec":"4.2.3.170","compounds":"(2E,6E)-farnesyl diphosphate + H2O = 4-epi-cubebol + diphosphate"}
{"X":45674,"RHEA_ID":44070,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+) => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + H2O"}
{"X":45675,"RHEA_ID":44071,"compounds":"1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)"}
{"X":45676,"RHEA_ID":47366,"compounds":"an aliphatic alcohol + dodecanoate + H(+) => dodecanoate ester + H2O"}
{"X":45677,"RHEA_ID":44073,"compounds":"1-O-alkyl-2-acyl-sn-glycerol + ATP => 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":45678,"RHEA_ID":44074,"compounds":"1-O-alkyl-2-acyl-sn-glycero-3-phosphate + ADP + H(+) => 1-O-alkyl-2-acyl-sn-glycerol + ATP"}
{"X":45679,"RHEA_ID":44075,"compounds":"1-O-alkyl-2-acyl-sn-glycerol + ATP <=> 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + ADP + H(+)"}
{"X":45680,"RHEA_ID":57388,"DIRECTION":"UN","MASTER_ID":57388,"ec":"1.14.14.167","compounds":"(13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] = (13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":45681,"RHEA_ID":47371,"DIRECTION":"BI","MASTER_ID":47368,"metacyc":"2.4.1.57-RXN","compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + GDP-alpha-D-mannose <=> 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1->2)-D-myo-inositol] + GDP + H(+)"}
{"X":45682,"RHEA_ID":44078,"compounds":"AMP + diphosphate + pentadecanoyl-CoA => ATP + CoA + pentadecanoate"}
{"X":45683,"RHEA_ID":44079,"compounds":"ATP + CoA + pentadecanoate <=> AMP + diphosphate + pentadecanoyl-CoA"}
{"X":45684,"RHEA_ID":47374,"compounds":"a quinol + D-glucono-1,5-lactone => a quinone + D-glucose"}
{"X":45685,"RHEA_ID":44081,"compounds":"ATP + CoA + undecanoate => AMP + diphosphate + undecanoyl-CoA"}
{"X":45686,"RHEA_ID":44082,"compounds":"AMP + diphosphate + undecanoyl-CoA => ATP + CoA + undecanoate"}
{"X":45687,"RHEA_ID":57395,"compounds":"(13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine <=> 3-O-acetyl-4'-O-demethylpapaveroxine + H(+)"}
{"X":45688,"RHEA_ID":47378,"compounds":"(25R)-3beta-hydroxycholest-5-en-7-one-26-al + 2 H2O + 2 oxidized [adrenodoxin] => (25R)-3beta,26-dihydroxycholest-5-en-7-one + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}
{"X":45689,"RHEA_ID":57397,"DIRECTION":"LR","MASTER_ID":57396,"metacyc":"RXN-13810","compounds":"(S)-S-adenosyl-L-methionine + 3-O-acetyl-4'-O-demethylpapaveroxine => 3-O-acetylpapaveroxine + H(+) + S-adenosyl-L-homocysteine"}
{"X":45690,"RHEA_ID":47380,"compounds":"(25R)-3beta-hydroxycholest-5-en-7-one-26-al + H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta-hydroxycholest-5-en-7-one-26-oate + H2O + 2 oxidized [adrenodoxin]"}
{"X":45691,"RHEA_ID":50756,"DIRECTION":"UN","MASTER_ID":50756,"ec":"1.19.1.1","compounds":"NADP(+) + reduced [flavodoxin] = 2 H(+) + NADPH + oxidized [flavodoxin]"}
{"X":45692,"RHEA_ID":47382,"compounds":"(25R)-3beta-hydroxycholest-5-en-7-one-26-oate + H2O + 2 oxidized [adrenodoxin] => (25R)-3beta-hydroxycholest-5-en-7-one-26-al + H(+) + O2 + 2 reduced [adrenodoxin]"}
{"X":45693,"RHEA_ID":54068,"DIRECTION":"UN","MASTER_ID":54068,"ec":"4.2.3.176","compounds":"(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O = diphosphate + sesterfisherol"}
{"X":45694,"RHEA_ID":44090,"compounds":"AMP + diphosphate + heptanoyl-CoA => ATP + CoA + heptanoate"}
{"X":45695,"RHEA_ID":57403,"compounds":"3-O-acetylpapaveroxine + H2O <=> acetate + H(+) + narcotine hemiacetal"}
{"X":45696,"RHEA_ID":47386,"compounds":"acetate + H(+) + hydroquinone => 4-acetoxyphenol + H2O"}
{"X":45697,"RHEA_ID":54072,"DIRECTION":"UN","MASTER_ID":54072,"ec":"4.2.3.177","compounds":"(2E)-geranyl diphosphate = beta-thujene + diphosphate"}
{"X":45698,"RHEA_ID":47388,"compounds":"H2O + tetradecanoate ester = an aliphatic alcohol + H(+) + tetradecanoate"}
{"X":45699,"RHEA_ID":50764,"DIRECTION":"UN","MASTER_ID":50764,"ec":"2.1.1.335","compounds":"4-amino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine = 4-methylamino-4-dedimethylamino-anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine"}
{"X":45700,"RHEA_ID":47390,"compounds":"an aliphatic alcohol + H(+) + tetradecanoate => H2O + tetradecanoate ester"}
{"X":45701,"RHEA_ID":47391,"compounds":"H2O + tetradecanoate ester <=> an aliphatic alcohol + H(+) + tetradecanoate"}
{"X":45702,"RHEA_ID":47392,"compounds":"H2O + hexadecanoate ester = an aliphatic alcohol + H(+) + hexadecanoate"}
{"X":45703,"RHEA_ID":44099,"compounds":"decan-1-ol + hexadecanoyl-CoA <=> CoA + decanyl hexadecanoate"}
{"X":45704,"RHEA_ID":47394,"compounds":"an aliphatic alcohol + H(+) + hexadecanoate => H2O + hexadecanoate ester"}
{"X":45705,"RHEA_ID":54080,"compounds":"5-carboxymethoxyuridine(34) in tRNA + S-adenosyl-L-methionine = 5-methoxycarbonylmethoxyuridine(34) in tRNA + S-adenosyl-L-homocysteine"}
{"X":45706,"RHEA_ID":44102,"compounds":"2 H(+) + NADH + octanoate => H2O + NAD(+) + octanal"}
{"X":45707,"RHEA_ID":44103,"compounds":"H2O + NAD(+) + octanal <=> 2 H(+) + NADH + octanoate"}
{"X":45708,"RHEA_ID":47398,"compounds":"an aliphatic alcohol + H(+) + octadecanoate => H2O + octadecanoate ester"}
{"X":45709,"RHEA_ID":54084,"DIRECTION":"UN","MASTER_ID":54084,"ec":"2.6.1.97","compounds":"7-cyano-7-carbaguanosine(15) in tRNA + H2O + L-glutamine = archaeosine(15) in tRNA + L-glutamate"}
{"X":45710,"RHEA_ID":44106,"compounds":"decanoate + 2 H(+) + NADH => decanal + H2O + NAD(+)"}
{"X":45711,"RHEA_ID":44107,"compounds":"decanal + H2O + NAD(+) <=> decanoate + 2 H(+) + NADH"}
{"X":45712,"RHEA_ID":54087,"DIRECTION":"BI","MASTER_ID":54084,"metacyc":"RXN-12145","compounds":"7-cyano-7-carbaguanosine(15) in tRNA + H2O + L-glutamine <=> archaeosine(15) in tRNA + L-glutamate"}
{"X":45713,"RHEA_ID":57421,"compounds":"NADH + 2 oxidized [cytochrome P450] => H(+) + NAD(+) + 2 reduced [cytochrome P450]"}
{"X":45714,"RHEA_ID":44110,"compounds":"2 H(+) + heptanoate + NADH => H2O + heptanal + NAD(+)"}
{"X":45715,"RHEA_ID":44111,"compounds":"H2O + heptanal + NAD(+) <=> 2 H(+) + heptanoate + NADH"}
{"X":45716,"RHEA_ID":54091,"compounds":"3,4-dihydroxyphenylacetate + H(+) + NADH + O2 <=> 2,4,5-trihydroxyphenylacetate + H2O + NAD(+)"}
{"X":45717,"RHEA_ID":47407,"compounds":"(24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA + NAD(+) <=> 3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH"}
{"X":45718,"RHEA_ID":44114,"compounds":"CoA + nonyl hexadecanoate => hexadecanoyl-CoA + nonan-1-ol"}
{"X":45719,"RHEA_ID":44115,"compounds":"hexadecanoyl-CoA + nonan-1-ol <=> CoA + nonyl hexadecanoate"}
{"X":45720,"RHEA_ID":54095,"compounds":"3,4-dihydroxyphenylacetate + H(+) + NADPH + O2 <=> 2,4,5-trihydroxyphenylacetate + H2O + NADP(+)"}
{"X":45721,"RHEA_ID":47411,"compounds":"(24E)-3alpha,7alpha-dihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O <=> (24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA"}
{"X":45722,"RHEA_ID":44118,"compounds":"CoA + eicosanyl hexadecanoate => eicosan-1-ol + hexadecanoyl-CoA"}
{"X":45723,"RHEA_ID":44119,"compounds":"eicosan-1-ol + hexadecanoyl-CoA <=> CoA + eicosanyl hexadecanoate"}
{"X":45724,"RHEA_ID":44120,"compounds":"hexadecanoyl-CoA + octadecan-1-ol = CoA + octadecanyl hexadecanoate"}
{"X":45725,"RHEA_ID":44122,"compounds":"CoA + octadecanyl hexadecanoate => hexadecanoyl-CoA + octadecan-1-ol"}
{"X":45726,"RHEA_ID":44123,"compounds":"hexadecanoyl-CoA + octadecan-1-ol <=> CoA + octadecanyl hexadecanoate"}
{"X":45727,"RHEA_ID":44124,"compounds":"hexadecanoyl-CoA + tetradecan-1-ol = CoA + tetradecanyl hexadecanoate"}
{"X":45728,"RHEA_ID":54102,"compounds":"H(+) + N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine"}
{"X":45729,"RHEA_ID":44126,"compounds":"CoA + tetradecanyl hexadecanoate => hexadecanoyl-CoA + tetradecan-1-ol"}
{"X":45730,"RHEA_ID":44127,"compounds":"hexadecanoyl-CoA + tetradecan-1-ol <=> CoA + tetradecanyl hexadecanoate"}
{"X":45731,"RHEA_ID":57440,"compounds":"2-methylanisole + O2 + reduced [NADH--hemoprotein reductase] = 2-hydroxytoluene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]"}
{"X":45732,"RHEA_ID":57441,"compounds":"2-methylanisole + O2 + reduced [NADH--hemoprotein reductase] => 2-hydroxytoluene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]"}
{"X":45733,"RHEA_ID":44130,"compounds":"CoA + hexadecanyl (9E)-octadecenoate => (9E)-octadecenoyl-CoA + hexadecan-1-ol"}
{"X":45734,"RHEA_ID":44131,"compounds":"(9E)-octadecenoyl-CoA + hexadecan-1-ol <=> CoA + hexadecanyl (9E)-octadecenoate"}
{"X":45735,"RHEA_ID":44132,"DIRECTION":"UN","MASTER_ID":44132,"ec":"2.5.1.128","compounds":"2 S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = 2 H(+) + N(4)-bis(aminopropyl)spermidine + 2 S-methyl-5'-thioadenosine"}
{"X":45736,"RHEA_ID":47427,"compounds":"(2E,9Z)-octadecadienoyl-CoA + H2O <=> (3S)-hydroxy-(9Z-octadecenoyl)-CoA"}
{"X":45737,"RHEA_ID":44134,"compounds":"2 H(+) + N(4)-bis(aminopropyl)spermidine + 2 S-methyl-5'-thioadenosine => 2 S-adenosyl 3-(methylsulfanyl)propylamine + spermidine"}
{"X":45738,"RHEA_ID":57447,"compounds":"C-terminal L-tyrosyl-L-glutamyl-L-glutamyl-[alpha-tubulin] + H2O <=> C-terminal detyrosinated L-glutamyl-L-glutamyl-[alpha-tubulin] + L-tyrosine"}
{"X":45739,"RHEA_ID":57448,"compounds":"ATP + D-tyrosine + tRNA(Tyr) = AMP + D-tyrosyl-tRNA(Tyr) + diphosphate + H(+)"}
{"X":45740,"RHEA_ID":47431,"compounds":"(3S)-hydroxy-(9Z-octadecenoyl)-CoA + NAD(+) <=> 3-oxo-(9Z-octadecenoyl)-CoA + H(+) + NADH"}
{"X":45741,"RHEA_ID":44138,"compounds":"CoA + hexadecanyl dodecanoate => dodecanoyl-CoA + hexadecan-1-ol"}
{"X":45742,"RHEA_ID":44139,"compounds":"dodecanoyl-CoA + hexadecan-1-ol <=> CoA + hexadecanyl dodecanoate"}
{"X":45743,"RHEA_ID":44140,"compounds":"CoA + 2 H(+) + oxidized [flavodoxin] + pyruvate = acetyl-CoA + CO2 + reduced [flavodoxin]"}
{"X":45744,"RHEA_ID":47435,"compounds":"(7Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,7Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":45745,"RHEA_ID":44142,"compounds":"acetyl-CoA + CO2 + reduced [flavodoxin] => CoA + 2 H(+) + oxidized [flavodoxin] + pyruvate"}
{"X":45746,"RHEA_ID":50812,"DIRECTION":"UN","MASTER_ID":50812,"ec":"1.14.15.19","compounds":"androst-4-ene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 1alpha-hydroxyandrost-4-ene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":45747,"RHEA_ID":57456,"compounds":"trans-sinapate + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-trans-sinapate + H(+) + UDP"}
{"X":45748,"RHEA_ID":47439,"compounds":"(2E,7Z)-hexadecadienoyl-CoA + H2O <=> (3S)-hydroxy-(7Z-hexadecenoyl)-CoA"}
{"X":45749,"RHEA_ID":44146,"compounds":"CoA + H(+) + N(alpha)-acetyl-L-methionine => acetyl-CoA + L-methionine"}
{"X":45750,"RHEA_ID":44147,"DIRECTION":"BI","MASTER_ID":44144,"ecocyc":"RXN0-6948","metacyc":"RXN0-6948","compounds":"acetyl-CoA + L-methionine <=> CoA + H(+) + N(alpha)-acetyl-L-methionine"}
{"X":45751,"RHEA_ID":57460,"compounds":"(E)-sinapoyl alcohol + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-trans-4-sinapoyl alcohol + H(+) + UDP"}
{"X":45752,"RHEA_ID":47443,"compounds":"(3S)-hydroxy-(7Z-hexadecenoyl)-CoA + NAD(+) <=> 3-oxo-(7Z-hexadecenoyl)-CoA + H(+) + NADH"}
{"X":45753,"RHEA_ID":44150,"compounds":"D-beta-lysine => L-lysine"}
{"X":45754,"RHEA_ID":44151,"DIRECTION":"BI","MASTER_ID":44148,"ecocyc":"RXN0-5192","metacyc":"RXN0-5192","compounds":"L-lysine <=> D-beta-lysine"}
{"X":45755,"RHEA_ID":44152,"DIRECTION":"UN","MASTER_ID":44152,"ec":"3.1.3.25","compounds":"1D-myo-inositol 2-phosphate + H2O = myo-inositol + phosphate"}
{"X":45756,"RHEA_ID":47447,"compounds":"3-oxo-(7Z-hexadecenoyl)-CoA + CoA <=> (5Z)-tetradecenoyl-CoA + acetyl-CoA"}
{"X":45757,"RHEA_ID":44154,"compounds":"myo-inositol + phosphate => 1D-myo-inositol 2-phosphate + H2O"}
{"X":45758,"RHEA_ID":44155,"compounds":"1D-myo-inositol 2-phosphate + H2O <=> myo-inositol + phosphate"}
{"X":45759,"RHEA_ID":44156,"DIRECTION":"UN","MASTER_ID":44156,"ec":"3.1.3.25","compounds":"1D-myo-inositol 5-phosphate + H2O = myo-inositol + phosphate"}
{"X":45760,"RHEA_ID":57469,"compounds":"trans-ferulate + UDP-alpha-D-glucose => 1-O-[(E)-feruloyl]-beta-D-glucose + UDP"}
{"X":45761,"RHEA_ID":44158,"compounds":"myo-inositol + phosphate => 1D-myo-inositol 5-phosphate + H2O"}
{"X":45762,"RHEA_ID":44159,"compounds":"1D-myo-inositol 5-phosphate + H2O <=> myo-inositol + phosphate"}
{"X":45763,"RHEA_ID":57472,"compounds":"trans-4-coumarate + UDP-alpha-D-glucose = 1-O-(trans-4-coumaroyl)-beta-D-glucose + UDP"}
{"X":45764,"RHEA_ID":57473,"compounds":"trans-4-coumarate + UDP-alpha-D-glucose => 1-O-(trans-4-coumaroyl)-beta-D-glucose + UDP"}
{"X":45765,"RHEA_ID":44162,"compounds":"myo-inositol + phosphate => 1D-myo-inositol 6-phosphate + H2O"}
{"X":45766,"RHEA_ID":44163,"compounds":"1D-myo-inositol 6-phosphate + H2O <=> myo-inositol + phosphate"}
{"X":45767,"RHEA_ID":44164,"compounds":"ATP + H2O = adenine + D-ribose 5-triphosphate"}
{"X":45768,"RHEA_ID":57477,"compounds":"dodecanoate + H2O2 => 2-hydroxydodecanoate + H2O"}
{"X":45769,"RHEA_ID":44166,"compounds":"adenine + D-ribose 5-triphosphate => ATP + H2O"}
{"X":45770,"RHEA_ID":44167,"compounds":"ATP + H2O <=> adenine + D-ribose 5-triphosphate"}
{"X":45771,"RHEA_ID":44168,"compounds":"dodecanoate + 2 H(+) + NADH = dodecanal + H2O + NAD(+)"}
{"X":45772,"RHEA_ID":54145,"compounds":"2 2-oxoglutarate + 5-methylcytidine(34) in mitochondrial tRNA(Met) + 2 O2 => 5-formylcytidine(34) in mitochondrial tRNA(Met) + 2 CO2 + H2O + 2 succinate"}
{"X":45773,"RHEA_ID":54146,"compounds":"5-formylcytidine(34) in mitochondrial tRNA(Met) + 2 CO2 + H2O + 2 succinate => 2 2-oxoglutarate + 5-methylcytidine(34) in mitochondrial tRNA(Met) + 2 O2"}
{"X":45774,"RHEA_ID":44171,"compounds":"dodecanoate + 2 H(+) + NADH <=> dodecanal + H2O + NAD(+)"}
{"X":45775,"RHEA_ID":44172,"compounds":"H2O + NAD(+) + tetradecanal = 2 H(+) + NADH + tetradecanoate"}
{"X":45776,"RHEA_ID":47467,"DIRECTION":"BI","MASTER_ID":47464,"ecocyc":"RXN0-5391","metacyc":"RXN0-5391","compounds":"(3E,5Z)-tetradecadienoyl-CoA <=> (2E,5Z)-tetradecadienoyl-CoA"}
{"X":45777,"RHEA_ID":54150,"compounds":"1-hydroxy-all-trans-1,2-dihydro-neurosporene + H2O => 1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene"}
{"X":45778,"RHEA_ID":44175,"compounds":"H2O + NAD(+) + tetradecanal <=> 2 H(+) + NADH + tetradecanoate"}
{"X":45779,"RHEA_ID":44176,"compounds":"a 2,3-diacyl-sn-glycerol + H2O = 3-acyl-sn-glycerol + a fatty acid + H(+)"}
{"X":45780,"RHEA_ID":54153,"compounds":"a uridine in rRNA + S-adenosyl-L-methionine => a 2'-O-methyluridine in rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":45781,"RHEA_ID":54154,"compounds":"a 2'-O-methyluridine in rRNA + H(+) + S-adenosyl-L-homocysteine => a uridine in rRNA + S-adenosyl-L-methionine"}
{"X":45782,"RHEA_ID":44179,"compounds":"a 2,3-diacyl-sn-glycerol + H2O <=> 3-acyl-sn-glycerol + a fatty acid + H(+)"}
{"X":45783,"RHEA_ID":44180,"compounds":"2-methylpropanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":45784,"RHEA_ID":57501,"compounds":"3-hydroxybutane-1,2,3-tricarboxylate => 2-methyl-cis-aconitate + H2O"}
{"X":45785,"RHEA_ID":54158,"compounds":"[ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + CO2 + succinate => 2-oxoglutarate + [ribosomal protein uS12]-L-proline + O2"}
{"X":45786,"RHEA_ID":44183,"compounds":"2-methylpropanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":45787,"RHEA_ID":44184,"DIRECTION":"UN","MASTER_ID":44184,"ec":"4.2.3.152","compounds":"D-sedoheptulose 7-phosphate = 2-epi-5-epi-valiolone + phosphate"}
{"X":45788,"RHEA_ID":44185,"DIRECTION":"LR","MASTER_ID":44184,"metacyc":"RXN-9140","compounds":"D-sedoheptulose 7-phosphate => 2-epi-5-epi-valiolone + phosphate"}
{"X":45789,"RHEA_ID":54162,"compounds":"[ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + CO2 + succinate => 2-oxoglutarate + [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + O2"}
{"X":45790,"RHEA_ID":54163,"compounds":"2-oxoglutarate + [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + O2 <=> [ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + CO2 + succinate"}
{"X":45791,"RHEA_ID":44188,"compounds":"(9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphate = 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":45792,"RHEA_ID":44189,"compounds":"(9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphate => 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":45793,"RHEA_ID":54166,"compounds":"a 5'-(N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + S-adenosyl-L-methionine"}
{"X":45794,"RHEA_ID":44191,"compounds":"(9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphate <=> 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":45795,"RHEA_ID":44192,"compounds":"2-methylhexadecanoate + ATP + CoA = 2-methylhexadecanoyl-CoA + AMP + diphosphate"}
{"X":45796,"RHEA_ID":54169,"compounds":"a 5'-(N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + S-adenosyl-L-methionine => a 5'-(N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":45797,"RHEA_ID":54170,"compounds":"a 5'-(N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-(N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + S-adenosyl-L-methionine"}
{"X":45798,"RHEA_ID":44195,"compounds":"2-methylhexadecanoate + ATP + CoA <=> 2-methylhexadecanoyl-CoA + AMP + diphosphate"}
{"X":45799,"RHEA_ID":44196,"compounds":"3-methylundecanoate + ATP + CoA = 3-methylundecanoyl-CoA + AMP + diphosphate"}
{"X":45800,"RHEA_ID":47491,"compounds":"12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH <=> isodeoxycholate + NADP(+)"}
{"X":45801,"RHEA_ID":44198,"compounds":"3-methylundecanoyl-CoA + AMP + diphosphate => 3-methylundecanoate + ATP + CoA"}
{"X":45802,"RHEA_ID":44199,"compounds":"3-methylundecanoate + ATP + CoA <=> 3-methylundecanoyl-CoA + AMP + diphosphate"}
{"X":45803,"RHEA_ID":44200,"compounds":"12-methyloctadecanoate + ATP + CoA = 12-methyloctadecanoyl-CoA + AMP + diphosphate"}
{"X":45804,"RHEA_ID":57521,"DIRECTION":"LR","MASTER_ID":57520,"metacyc":"RXN-19637","compounds":"15,16-epoxydolabrene + O2 + reduced [NADPH--hemoprotein reductase] => 3beta-hydroxy-15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":45805,"RHEA_ID":54178,"DIRECTION":"RL","MASTER_ID":54176,"metacyc":"RXN-11706","compounds":"a long-chain fatty acyl-[ACP] + H(+) + NADPH => a long-chain fatty aldehyde + holo-[ACP] + NADP(+)"}
{"X":45806,"RHEA_ID":44203,"compounds":"12-methyloctadecanoate + ATP + CoA <=> 12-methyloctadecanoyl-CoA + AMP + diphosphate"}
{"X":45807,"RHEA_ID":44204,"compounds":"2-hydroxyhexadecanoate + ATP + CoA = 2-hydroxyhexadecanoyl-CoA + AMP + diphosphate"}
{"X":45808,"RHEA_ID":50874,"compounds":"(5,6,15R)-trihydroxy-(7E,9E,11Z,13E,17Z)-eicosapentaenoate => (15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + O2"}
{"X":45809,"RHEA_ID":44206,"compounds":"2-hydroxyhexadecanoyl-CoA + AMP + diphosphate => 2-hydroxyhexadecanoate + ATP + CoA"}
{"X":45810,"RHEA_ID":44207,"compounds":"2-hydroxyhexadecanoate + ATP + CoA <=> 2-hydroxyhexadecanoyl-CoA + AMP + diphosphate"}
{"X":45811,"RHEA_ID":54184,"DIRECTION":"UN","MASTER_ID":54184,"ec":"3.5.1.114","metacyc":"RXN-13683","compounds":"an N-acyl-aromatic L-alpha-amino acid + H2O = a carboxylate + an aromatic L-alpha-amino acid"}
{"X":45812,"RHEA_ID":47503,"compounds":"cholate + NADP(+) <=> 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH"}
{"X":45813,"RHEA_ID":44210,"compounds":"12-methyltridecanoyl-CoA + AMP + diphosphate => 12-methyltridecanoate + ATP + CoA"}
{"X":45814,"RHEA_ID":44211,"compounds":"12-methyltridecanoate + ATP + CoA <=> 12-methyltridecanoyl-CoA + AMP + diphosphate"}
{"X":45815,"RHEA_ID":54188,"compounds":"H2O + N-acetyl-L-phenylalanine = acetate + L-phenylalanine"}
{"X":45816,"RHEA_ID":44213,"compounds":"3-hydroxytetradecanoate + ATP + CoA => 3-hydroxytetradecanoyl-CoA + AMP + diphosphate"}
{"X":45817,"RHEA_ID":54190,"compounds":"acetate + L-phenylalanine => H2O + N-acetyl-L-phenylalanine"}
{"X":45818,"RHEA_ID":44215,"compounds":"3-hydroxytetradecanoate + ATP + CoA <=> 3-hydroxytetradecanoyl-CoA + AMP + diphosphate"}
{"X":45819,"RHEA_ID":54192,"compounds":"L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine"}
{"X":45820,"RHEA_ID":54193,"compounds":"L-lysyl-[protein] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine"}
{"X":45821,"RHEA_ID":44218,"compounds":"12-hydroxyoctadecanoyl-CoA + AMP + diphosphate => 12-hydroxyoctadecanoate + ATP + CoA"}
{"X":45822,"RHEA_ID":54195,"compounds":"L-lysyl-[protein] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine"}
{"X":45823,"RHEA_ID":44220,"compounds":"15-hydroxypentadecanoate + ATP + CoA = 15-hydroxypentadecanoyl-CoA + AMP + diphosphate"}
{"X":45824,"RHEA_ID":44221,"compounds":"15-hydroxypentadecanoate + ATP + CoA => 15-hydroxypentadecanoyl-CoA + AMP + diphosphate"}
{"X":45825,"RHEA_ID":61128,"compounds":"O2 + quercetin + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + myricetin + oxidized [NADPH--hemoprotein reductase]"}
{"X":45826,"RHEA_ID":47517,"compounds":"7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH => isochenodeoxycholate + NAD(+)"}
{"X":45827,"RHEA_ID":44224,"compounds":"16-hydroxyhexadecanoate + ATP + CoA = 16-hydroxyhexadecanoyl-CoA + AMP + diphosphate"}
{"X":45828,"RHEA_ID":54201,"compounds":"N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":45829,"RHEA_ID":44226,"compounds":"16-hydroxyhexadecanoyl-CoA + AMP + diphosphate => 16-hydroxyhexadecanoate + ATP + CoA"}
{"X":45830,"RHEA_ID":47521,"compounds":"3-oxo-5beta-cholan-24-oate + H(+) + NADPH => isolithocholate + NADP(+)"}
{"X":45831,"RHEA_ID":44228,"compounds":"9-decenoate + ATP + CoA = 9-decenoyl-CoA + AMP + diphosphate"}
{"X":45832,"RHEA_ID":54205,"compounds":"2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 2 O2 => 2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine"}
{"X":45833,"RHEA_ID":44230,"compounds":"9-decenoyl-CoA + AMP + diphosphate => 9-decenoate + ATP + CoA"}
{"X":45834,"RHEA_ID":54207,"compounds":"2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 2 O2 <=> 2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine"}
{"X":45835,"RHEA_ID":44232,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":45836,"RHEA_ID":54209,"compounds":"2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2 => 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O"}
{"X":45837,"RHEA_ID":44234,"compounds":"1,2,3-tri-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol"}
{"X":45838,"RHEA_ID":47529,"compounds":"7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH => isocholate + NADP(+)"}
{"X":45839,"RHEA_ID":44236,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}
{"X":45840,"RHEA_ID":54213,"compounds":"2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 2 O2 => 2-(prostaglandin G2)-sn-glycero-3-phosphocholine"}
{"X":45841,"RHEA_ID":44238,"compounds":"1,2,3-tri-(9Z-octadecenoyl)-glycerol + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol"}
{"X":45842,"RHEA_ID":54215,"compounds":"2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 2 O2 <=> 2-(prostaglandin G2)-sn-glycero-3-phosphocholine"}
{"X":45843,"RHEA_ID":44240,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol = a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + di-(9Z)-octadecenoylglycerol"}
{"X":45844,"RHEA_ID":54217,"compounds":"2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2 => 2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O"}
{"X":45845,"RHEA_ID":44242,"compounds":"a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + di-(9Z)-octadecenoylglycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol"}
{"X":45846,"RHEA_ID":47537,"compounds":"7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH => isochenodeoxycholate + NADP(+)"}
{"X":45847,"RHEA_ID":44244,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-glycerol + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}
{"X":45848,"RHEA_ID":54221,"compounds":"1-hydroxy-all-trans-1,2-dihydro-neurosporene => all-trans-neurosporene + H2O"}
{"X":45849,"RHEA_ID":44246,"compounds":"1,2-di-(9Z-octadecenoyl)-glycerol + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-(9Z-octadecenoyl)-glycerol"}
{"X":45850,"RHEA_ID":47541,"compounds":"7-oxolithocholate + H(+) + NADPH => NADP(+) + ursodeoxycholate"}
{"X":45851,"RHEA_ID":44248,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":45852,"RHEA_ID":44249,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":45853,"RHEA_ID":44250,"compounds":"1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":45854,"RHEA_ID":54227,"compounds":"2-(prostaglandin H2)-sn-glycero-3-phosphocholine <=> 2-(prostaglandin E2)-sn-glycero-3-phosphocholine"}
{"X":45855,"RHEA_ID":54228,"compounds":"2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine = 2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine"}
{"X":45856,"RHEA_ID":44253,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":45857,"RHEA_ID":44254,"compounds":"1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":45858,"RHEA_ID":44255,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":45859,"RHEA_ID":54232,"compounds":"1,2-dioctanoyl-sn-glycerol + CDP-choline = 1,2-dioctanoyl-sn-glycero-3-phosphocholine + CMP + H(+)"}
{"X":45860,"RHEA_ID":54233,"compounds":"1,2-dioctanoyl-sn-glycerol + CDP-choline => 1,2-dioctanoyl-sn-glycero-3-phosphocholine + CMP + H(+)"}
{"X":45861,"RHEA_ID":44258,"compounds":"1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine"}
{"X":45862,"RHEA_ID":54235,"compounds":"1,2-dioctanoyl-sn-glycerol + CDP-choline <=> 1,2-dioctanoyl-sn-glycero-3-phosphocholine + CMP + H(+)"}
{"X":45863,"RHEA_ID":54236,"compounds":"1,2-didecanoyl-sn-glycerol + CDP-choline = 1,2-didecanoyl-sn-glycero-3-phosphocholine + CMP + H(+)"}
{"X":45864,"RHEA_ID":54237,"compounds":"1,2-didecanoyl-sn-glycerol + CDP-choline => 1,2-didecanoyl-sn-glycero-3-phosphocholine + CMP + H(+)"}
{"X":45865,"RHEA_ID":44262,"compounds":"4-hydroxy-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA => 2 H(+) + hexadecanoyl-CoA + 2 malonyl-CoA"}
{"X":45866,"RHEA_ID":54239,"compounds":"1,2-didecanoyl-sn-glycerol + CDP-choline <=> 1,2-didecanoyl-sn-glycero-3-phosphocholine + CMP + H(+)"}
{"X":45867,"RHEA_ID":54240,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-choline = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)"}
{"X":45868,"RHEA_ID":54241,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-choline => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)"}
{"X":45869,"RHEA_ID":44266,"compounds":"4-hydroxy-6-nonadecylpyran-2-one + 2 CO2 + 3 CoA => eicosanoyl-CoA + 2 H(+) + 2 malonyl-CoA"}
{"X":45870,"RHEA_ID":54243,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-choline <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)"}
{"X":45871,"RHEA_ID":54244,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)"}
{"X":45872,"RHEA_ID":54245,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)"}
{"X":45873,"RHEA_ID":44270,"compounds":"4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA => 3 H(+) + hexadecanoyl-CoA + 3 malonyl-CoA"}
{"X":45874,"RHEA_ID":54247,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)"}
{"X":45875,"RHEA_ID":44272,"compounds":"3 H(+) + 3 malonyl-CoA + octadecanoyl-CoA = 4-hydroxy-6-(2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA"}
{"X":45876,"RHEA_ID":54249,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)"}
{"X":45877,"RHEA_ID":44274,"compounds":"4-hydroxy-6-(2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA => 3 H(+) + 3 malonyl-CoA + octadecanoyl-CoA"}
{"X":45878,"RHEA_ID":54251,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)"}
{"X":45879,"RHEA_ID":54252,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)"}
{"X":45880,"RHEA_ID":54253,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)"}
{"X":45881,"RHEA_ID":44278,"compounds":"4-hydroxy-6-(2-oxohenicosyl)pyran-2-one + 3 CO2 + 4 CoA => eicosanoyl-CoA + 3 H(+) + 3 malonyl-CoA"}
{"X":45882,"RHEA_ID":54255,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)"}
{"X":45883,"RHEA_ID":54256,"compounds":"2-oxoglutarate + L-histidyl-[protein] + O2 = (3S)-3-hydroxy-L-histidyl-[protein] + CO2 + succinate"}
{"X":45884,"RHEA_ID":44281,"compounds":"2 H(+) + 2 malonyl-CoA + octadecanoyl-CoA => 4-hydroxy-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA"}
{"X":45885,"RHEA_ID":44282,"compounds":"4-hydroxy-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA => 2 H(+) + 2 malonyl-CoA + octadecanoyl-CoA"}
{"X":45886,"RHEA_ID":44283,"compounds":"2 H(+) + 2 malonyl-CoA + octadecanoyl-CoA <=> 4-hydroxy-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA"}
{"X":45887,"RHEA_ID":54260,"compounds":"2-oxoglutarate + L-asparaginyl-[protein] + O2 = (3S)-3-hydroxy-L-asparaginyl-[protein] + CO2 + succinate"}
{"X":45888,"RHEA_ID":44285,"compounds":"2 H(+) + 2 malonyl-CoA + octanoyl-CoA => 4-hydroxy-6-heptylpyran-2-one + 2 CO2 + 3 CoA"}
{"X":45889,"RHEA_ID":44286,"compounds":"4-hydroxy-6-heptylpyran-2-one + 2 CO2 + 3 CoA => 2 H(+) + 2 malonyl-CoA + octanoyl-CoA"}
{"X":45890,"RHEA_ID":54263,"compounds":"2-oxoglutarate + L-asparaginyl-[protein] + O2 <=> (3S)-3-hydroxy-L-asparaginyl-[protein] + CO2 + succinate"}
{"X":45891,"RHEA_ID":54264,"DIRECTION":"UN","MASTER_ID":54264,"ec":"1.14.11.n4","compounds":"2-oxoglutarate + L-histidyl-[ankyrin-repeat domain protein] + O2 = (3S)-3-hydroxy-L-histidyl-[ankyrin-repeat domain protein] + CO2 + succinate"}
{"X":45892,"RHEA_ID":54265,"compounds":"2-oxoglutarate + L-histidyl-[ankyrin-repeat domain protein] + O2 => (3S)-3-hydroxy-L-histidyl-[ankyrin-repeat domain protein] + CO2 + succinate"}
{"X":45893,"RHEA_ID":44290,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+) => 1,2-di-(9Z-octadecenoyl)-glycerol + CDP-choline"}
{"X":45894,"RHEA_ID":54267,"compounds":"2-oxoglutarate + L-histidyl-[ankyrin-repeat domain protein] + O2 <=> (3S)-3-hydroxy-L-histidyl-[ankyrin-repeat domain protein] + CO2 + succinate"}
{"X":45895,"RHEA_ID":44292,"compounds":"1,2-di-(9Z-octadecenoyl)-glycerol + CDP-ethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)"}
{"X":45896,"RHEA_ID":44293,"compounds":"1,2-di-(9Z-octadecenoyl)-glycerol + CDP-ethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)"}
{"X":45897,"RHEA_ID":44294,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+) => 1,2-di-(9Z-octadecenoyl)-glycerol + CDP-ethanolamine"}
{"X":45898,"RHEA_ID":54271,"compounds":"2-oxoglutarate + [hypoxia-inducible factor alpha subunit]-L-asparagine + O2 <=> [hypoxia-inducible factor alpha subunit]-(3S)-3-hydroxy-L-asparagine + CO2 + succinate"}
{"X":45899,"RHEA_ID":54272,"DIRECTION":"UN","MASTER_ID":54272,"ec":"1.14.11.n4","compounds":"2-oxoglutarate + L-asparaginyl-[ankyrin-repeat domain protein] + O2 = (3S)-3-hydroxy-L-asparaginyl-[ankyrin-repeat domain protein] + CO2 + succinate"}
{"X":45900,"RHEA_ID":54273,"compounds":"2-oxoglutarate + L-asparaginyl-[ankyrin-repeat domain protein] + O2 => (3S)-3-hydroxy-L-asparaginyl-[ankyrin-repeat domain protein] + CO2 + succinate"}
{"X":45901,"RHEA_ID":44298,"compounds":"4-hydroxy-5-methyl-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA => 2 H(+) + hexadecanoyl-CoA + malonyl-CoA + methylmalonyl-CoA"}
{"X":45902,"RHEA_ID":54275,"compounds":"2-oxoglutarate + L-asparaginyl-[ankyrin-repeat domain protein] + O2 <=> (3S)-3-hydroxy-L-asparaginyl-[ankyrin-repeat domain protein] + CO2 + succinate"}
{"X":45903,"RHEA_ID":54276,"compounds":"2-oxoglutarate + L-aspartyl-[protein] + O2 = (3S)-3-hydroxy-L-aspartyl-[protein] + CO2 + succinate"}
{"X":45904,"RHEA_ID":54277,"compounds":"2-oxoglutarate + L-aspartyl-[protein] + O2 => (3S)-3-hydroxy-L-aspartyl-[protein] + CO2 + succinate"}
{"X":45905,"RHEA_ID":44302,"compounds":"4-hydroxy-5-methyl-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA => 2 H(+) + malonyl-CoA + methylmalonyl-CoA + octadecanoyl-CoA"}
{"X":45906,"RHEA_ID":54279,"compounds":"2-oxoglutarate + L-aspartyl-[protein] + O2 <=> (3S)-3-hydroxy-L-aspartyl-[protein] + CO2 + succinate"}
{"X":45907,"RHEA_ID":54280,"DIRECTION":"UN","MASTER_ID":54280,"ec":"1.14.11.n4","compounds":"2-oxoglutarate + L-aspartyl-[ankyrin-repeat domain protein] + O2 = (3S)-3-hydroxy-L-aspartyl-[ankyrin-repeat domain protein] + CO2 + succinate"}
{"X":45908,"RHEA_ID":44305,"compounds":"a 1-acyl-sn-glycero-3-phosphate + dodecanoyl-CoA => a 1-acyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":45909,"RHEA_ID":44306,"compounds":"a 1-acyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA => a 1-acyl-sn-glycero-3-phosphate + dodecanoyl-CoA"}
{"X":45910,"RHEA_ID":54283,"compounds":"2-oxoglutarate + L-aspartyl-[ankyrin-repeat domain protein] + O2 <=> (3S)-3-hydroxy-L-aspartyl-[ankyrin-repeat domain protein] + CO2 + succinate"}
{"X":45911,"RHEA_ID":54284,"compounds":"H2O + N-(octadecanoyl)-sphing-4-enine-1-phosphocholine = H(+) + N-octadecanoylsphing-4-enine + phosphocholine"}
{"X":45912,"RHEA_ID":44309,"compounds":"(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phosphoethanolamine => 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":45913,"RHEA_ID":44310,"compounds":"1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":45914,"RHEA_ID":54287,"compounds":"H2O + N-(octadecanoyl)-sphing-4-enine-1-phosphocholine <=> H(+) + N-octadecanoylsphing-4-enine + phosphocholine"}
{"X":45915,"RHEA_ID":54288,"DIRECTION":"UN","MASTER_ID":54288,"ec":"2.7.7.n1","compounds":"ATP + L-tyrosyl-[protein] = diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein]"}
{"X":45916,"RHEA_ID":44313,"compounds":"1-tetradecanoylglycerol + H2O => glycerol + H(+) + tetradecanoate"}
{"X":45917,"RHEA_ID":44314,"compounds":"glycerol + H(+) + tetradecanoate => 1-tetradecanoylglycerol + H2O"}
{"X":45918,"RHEA_ID":54291,"compounds":"ATP + L-tyrosyl-[protein] <=> diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein]"}
{"X":45919,"RHEA_ID":44316,"compounds":"1-dodecanoylglycerol + H2O = dodecanoate + glycerol + H(+)"}
{"X":45920,"RHEA_ID":44317,"compounds":"1-dodecanoylglycerol + H2O => dodecanoate + glycerol + H(+)"}
{"X":45921,"RHEA_ID":44318,"compounds":"dodecanoate + glycerol + H(+) => 1-dodecanoylglycerol + H2O"}
{"X":45922,"RHEA_ID":54295,"compounds":"ATP + L-threonyl-[protein] <=> 3-O-(5'-adenylyl)-L-threonyl-[protein] + diphosphate"}
{"X":45923,"RHEA_ID":54296,"DIRECTION":"UN","MASTER_ID":54296,"ec":"2.7.7.n6","compounds":"GTP + L-tyrosyl-[protein] = diphosphate + O-(5'-guanylyl)-L-tyrosyl-[protein]"}
{"X":45924,"RHEA_ID":54297,"compounds":"GTP + L-tyrosyl-[protein] => diphosphate + O-(5'-guanylyl)-L-tyrosyl-[protein]"}
{"X":45925,"RHEA_ID":44322,"compounds":"decanoate + glycerol + H(+) => 1-decanoylglycerol + H2O"}
{"X":45926,"RHEA_ID":44323,"compounds":"1-decanoylglycerol + H2O <=> decanoate + glycerol + H(+)"}
{"X":45927,"RHEA_ID":54300,"DIRECTION":"UN","MASTER_ID":54300,"ec":"2.8.2.33","compounds":"n 3'-phosphoadenylyl sulfate + chondroitin 4'-sulfate = n adenosine 3',5'-bisphosphate + chondroitin 4',6'-disulfate + n H(+)"}
{"X":45928,"RHEA_ID":54301,"DIRECTION":"LR","MASTER_ID":54300,"metacyc":"RXN-7954","compounds":"n 3'-phosphoadenylyl sulfate + chondroitin 4'-sulfate => n adenosine 3',5'-bisphosphate + chondroitin 4',6'-disulfate + n H(+)"}
{"X":45929,"RHEA_ID":44326,"compounds":"butanoate + glycerol + H(+) => 1-butyrylglycerol + H2O"}
{"X":45930,"RHEA_ID":47621,"compounds":"2-ethylhexyl sulfate + 2-oxoglutarate + O2 => 2-ethylhexanal + CO2 + H(+) + succinate + sulfate"}
{"X":45931,"RHEA_ID":54304,"DIRECTION":"UN","MASTER_ID":54304,"ec":"2.8.2.33","compounds":"n 3'-phosphoadenylyl sulfate + dermatan 4'-sulfate = n adenosine 3',5'-bisphosphate + dermatan 4',6'-disulfate + n H(+)"}
{"X":45932,"RHEA_ID":54305,"DIRECTION":"LR","MASTER_ID":54304,"metacyc":"RXN-7953","compounds":"n 3'-phosphoadenylyl sulfate + dermatan 4'-sulfate => n adenosine 3',5'-bisphosphate + dermatan 4',6'-disulfate + n H(+)"}
{"X":45933,"RHEA_ID":44330,"compounds":"glycerol + H(+) + octanoate => 1-octanoylglycerol + H2O"}
{"X":45934,"RHEA_ID":57655,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GA1 <=> CMP + ganglioside GM1alpha + H(+)"}
{"X":45935,"RHEA_ID":54308,"DIRECTION":"UN","MASTER_ID":54308,"ec":"2.1.1.260","compounds":"pseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-homocysteine"}
{"X":45936,"RHEA_ID":44333,"DIRECTION":"LR","MASTER_ID":44332,"metacyc":"RXN-16296","compounds":"ATP + L-alanine + L-anticapsin => ADP + bacilysin + H(+) + phosphate"}
{"X":45937,"RHEA_ID":44334,"compounds":"ADP + bacilysin + H(+) + phosphate => ATP + L-alanine + L-anticapsin"}
{"X":45938,"RHEA_ID":57659,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GD1b <=> CMP + ganglioside GT1balpha + H(+)"}
{"X":45939,"RHEA_ID":44336,"DIRECTION":"UN","MASTER_ID":44336,"ec":"6.3.2.48","compounds":"an L-alpha-amino acid + ATP + L-arginine = ADP + H(+) + L-arginyl-L-alpha-amino acid + phosphate"}
{"X":45940,"RHEA_ID":54321,"compounds":"2 [Fe(II)-cytochrome b5] + a Delta(7)-sterol + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a Delta(5),Delta(7)-sterol + 2 H2O"}
{"X":45941,"RHEA_ID":44338,"compounds":"ADP + H(+) + L-arginyl-L-alpha-amino acid + phosphate => an L-alpha-amino acid + ATP + L-arginine"}
{"X":45942,"RHEA_ID":57663,"compounds":"(+)-valencene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (+)-nootkatone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":45943,"RHEA_ID":44340,"DIRECTION":"UN","MASTER_ID":44340,"ec":"6.3.2.46","compounds":"(S)-2,3-diaminopropanoate + ATP + fumarate = AMP + diphosphate + N(3)-fumaroyl-(S)-2,3-diaminopropanoate"}
{"X":45944,"RHEA_ID":54325,"compounds":"a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid + 16 oxidized [2Fe-2S]-[ferredoxin] => a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 16 H(+) + 16 reduced [2Fe-2S]-[ferredoxin]"}
{"X":45945,"RHEA_ID":44342,"compounds":"AMP + diphosphate + N(3)-fumaroyl-(S)-2,3-diaminopropanoate => (S)-2,3-diaminopropanoate + ATP + fumarate"}
{"X":45946,"RHEA_ID":57667,"compounds":"(+)-valencene + O2 + reduced [NADPH--hemoprotein reductase] <=> alpha-nootkatol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":45947,"RHEA_ID":44344,"DIRECTION":"UN","MASTER_ID":44344,"ec":"6.3.2.47","compounds":"ATP + L-valine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate = ADP + dapdiamide A + H(+) + phosphate"}
{"X":45948,"RHEA_ID":54329,"compounds":"2 H(+) + hexadecanoyl-[ACP] + 2 NADPH => hexadecan-1-ol + holo-[ACP] + 2 NADP(+)"}
{"X":45949,"RHEA_ID":44346,"compounds":"ADP + dapdiamide A + H(+) + phosphate => ATP + L-valine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate"}
{"X":45950,"RHEA_ID":57671,"compounds":"alpha-nootkatol + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-nootkatone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":45951,"RHEA_ID":54332,"compounds":"1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)"}
{"X":45952,"RHEA_ID":54333,"compounds":"1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + CDP-choline => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)"}
{"X":45953,"RHEA_ID":44350,"compounds":"ADP + dapdiamide B + H(+) + phosphate => ATP + L-isoleucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate"}
{"X":45954,"RHEA_ID":57675,"compounds":"(+)-5-epi-aristolochene + O2 + reduced [NADPH--hemoprotein reductase] <=> 2beta-hydroxy-5-epi-aristolochene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":45955,"RHEA_ID":54336,"compounds":"1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-choline = 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)"}
{"X":45956,"RHEA_ID":54337,"compounds":"1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-choline => 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)"}
{"X":45957,"RHEA_ID":44354,"compounds":"ADP + dapdiamide C + H(+) + phosphate => ATP + L-leucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate"}
{"X":45958,"RHEA_ID":57679,"compounds":"4-epi-eremophilene + O2 + reduced [NADPH--hemoprotein reductase] <=> 4-epi-eremophilene-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":45959,"RHEA_ID":54340,"compounds":"1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-ethanolamine = 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)"}
{"X":45960,"RHEA_ID":54341,"compounds":"1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-ethanolamine => 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)"}
{"X":45961,"RHEA_ID":44358,"compounds":"methyl nogalonate => nogalaviketone"}
{"X":45962,"RHEA_ID":57683,"compounds":"a flavanone + O2 + reduced [NADPH--hemoprotein reductase] <=> a flavone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":45963,"RHEA_ID":44360,"DIRECTION":"UN","MASTER_ID":44360,"ec":"5.3.1.32","compounds":"(S)-4-hydroxy-2,3-pentanedione-5-phosphate = 3-hydroxy-2,4-pentanedione 5-phosphate"}
{"X":45964,"RHEA_ID":54345,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)"}
{"X":45965,"RHEA_ID":44362,"compounds":"3-hydroxy-2,4-pentanedione 5-phosphate => (S)-4-hydroxy-2,3-pentanedione-5-phosphate"}
{"X":45966,"RHEA_ID":57691,"compounds":"apo-[corrinoid adenosyltransferase] + cob(II)inamide <=> cob(II)inamide--[corrinoid adenosyltransferase]"}
{"X":45967,"RHEA_ID":44364,"DIRECTION":"UN","MASTER_ID":44364,"ec":"2.7.1.188","compounds":"2-epi-5-epi-valiolone + ATP = 2-epi-5-epi-valiolone 7-phosphate + ADP + H(+)"}
{"X":45968,"RHEA_ID":54349,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycerol + CDP-choline => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+)"}
{"X":45969,"RHEA_ID":44366,"compounds":"2-epi-5-epi-valiolone 7-phosphate + ADP + H(+) => 2-epi-5-epi-valiolone + ATP"}
{"X":45970,"RHEA_ID":44367,"DIRECTION":"BI","MASTER_ID":44364,"metacyc":"RXN-16279","compounds":"2-epi-5-epi-valiolone + ATP <=> 2-epi-5-epi-valiolone 7-phosphate + ADP + H(+)"}
{"X":45971,"RHEA_ID":54352,"compounds":"1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CMP + H(+)"}
{"X":45972,"RHEA_ID":44369,"DIRECTION":"LR","MASTER_ID":44368,"ecocyc":"RXN0-3381","metacyc":"RXN0-3381","compounds":"Cr(6+) + 2 NADPH + O2 => Cr(3+) + 2 H(+) + 2 NADP(+) + superoxide"}
{"X":45973,"RHEA_ID":44370,"compounds":"Cr(3+) + 2 H(+) + 2 NADP(+) + superoxide => Cr(6+) + 2 NADPH + O2"}
{"X":45974,"RHEA_ID":44371,"compounds":"Cr(6+) + 2 NADPH + O2 <=> Cr(3+) + 2 H(+) + 2 NADP(+) + superoxide"}
{"X":45975,"RHEA_ID":47666,"compounds":"2''-O-glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD(+)"}
{"X":45976,"RHEA_ID":44373,"DIRECTION":"LR","MASTER_ID":44372,"ecocyc":"RXN0-3381","metacyc":"RXN0-3381","compounds":"Cr(6+) + 2 NADH + O2 => Cr(3+) + 2 H(+) + 2 NAD(+) + superoxide"}
{"X":45977,"RHEA_ID":54358,"compounds":"2-methylpropanal + CO2 => 3-methyl-2-oxobutanoate + H(+)"}
{"X":45978,"RHEA_ID":44375,"compounds":"Cr(6+) + 2 NADH + O2 <=> Cr(3+) + 2 H(+) + 2 NAD(+) + superoxide"}
{"X":45979,"RHEA_ID":47670,"compounds":"2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+)"}
{"X":45980,"RHEA_ID":44377,"compounds":"a 1-acyl-sn-glycero-3-phosphocholine(in) => a 1-acyl-sn-glycero-3-phosphocholine(out)"}
{"X":45981,"RHEA_ID":54362,"compounds":"3-methylbutanal + CO2 => 4-methyl-2-oxopentanoate + H(+)"}
{"X":45982,"RHEA_ID":44379,"compounds":"a 1-acyl-sn-glycero-3-phosphocholine(in) <=> a 1-acyl-sn-glycero-3-phosphocholine(out)"}
{"X":45983,"RHEA_ID":47674,"compounds":"2''-O-malonyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-malonyl-L-lysyl-[protein] + NAD(+)"}
{"X":45984,"RHEA_ID":44381,"DIRECTION":"LR","MASTER_ID":44380,"metacyc":"RXN-11758","compounds":"a 3-demethylubiquinol + S-adenosyl-L-methionine => a ubiquinol + H(+) + S-adenosyl-L-homocysteine"}
{"X":45985,"RHEA_ID":54366,"compounds":"acetoin => 2 acetaldehyde"}
{"X":45986,"RHEA_ID":54367,"compounds":"2 acetaldehyde <=> acetoin"}
{"X":45987,"RHEA_ID":47678,"compounds":"ADP + H(+) + N-acetyl-D-galactosamine 6-phosphate => ATP + N-acetyl-D-galactosamine"}
{"X":45988,"RHEA_ID":44385,"compounds":"1-heptadecanoyl-sn-glycero-3-phosphate + dodecanoyl-CoA => 1-heptadecanoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":45989,"RHEA_ID":54370,"compounds":"acetoin + CO2 => acetaldehyde + H(+) + pyruvate"}
{"X":45990,"RHEA_ID":44387,"compounds":"1-heptadecanoyl-sn-glycero-3-phosphate + dodecanoyl-CoA <=> 1-heptadecanoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":45991,"RHEA_ID":54372,"DIRECTION":"UN","MASTER_ID":54372,"ec":"4.2.3.182","compounds":"(2E,6E)-farnesyl diphosphate + H2O = (+)-(2S,3R,9R)-pristinol + diphosphate"}
{"X":45992,"RHEA_ID":44389,"compounds":"1-heptadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA => 1-heptadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":45993,"RHEA_ID":54374,"compounds":"(+)-(2S,3R,9R)-pristinol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}
{"X":45994,"RHEA_ID":44391,"compounds":"1-heptadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA <=> 1-heptadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":45995,"RHEA_ID":57720,"DIRECTION":"UN","MASTER_ID":57720,"ec":"7.1.2.2","compounds":"ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate"}
{"X":45996,"RHEA_ID":47687,"DIRECTION":"BI","MASTER_ID":47684,"metacyc":"RXN-15696","compounds":"[(1->2)-beta-D-glucosyl](n) + phosphate <=> [(1->2)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate"}
{"X":45997,"RHEA_ID":54378,"compounds":"diphosphate + nezukol => (+)-copalyl diphosphate + H2O"}
{"X":45998,"RHEA_ID":44395,"compounds":"1-heptadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA <=> 1-heptadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":45999,"RHEA_ID":47690,"compounds":"Delta(1)-pyrroline-(4S)-hydroxy-2-carboxylate + 2 H(+) + NADPH => cis-4-hydroxy-L-proline + NADP(+)"}
{"X":46000,"RHEA_ID":44397,"compounds":"1-heptadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA => 1-heptadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":46001,"RHEA_ID":54382,"compounds":"5-hydroxy-alpha-gurjunene + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}
{"X":46002,"RHEA_ID":44399,"compounds":"1-heptadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA <=> 1-heptadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA"}
{"X":46003,"RHEA_ID":47694,"compounds":"5'-deoxyadenosine + A + H(+) + L-methionine + neomycin B => AH2 + neomycin C + S-adenosyl-L-methionine"}
{"X":46004,"RHEA_ID":44401,"DIRECTION":"LR","MASTER_ID":44400,"metacyc":"RXN3O-102","compounds":"3-demethylubiquinol-6 + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + ubiquinol-6"}
{"X":46005,"RHEA_ID":54386,"DIRECTION":"RL","MASTER_ID":54384,"metacyc":"1.3.99.5-RXN","compounds":"a 3-oxo-Delta(4)-steroid + H(+) + NADPH => a 3-oxo-5alpha-steroid + NADP(+)"}
{"X":46006,"RHEA_ID":54387,"compounds":"a 3-oxo-5alpha-steroid + NADP(+) <=> a 3-oxo-Delta(4)-steroid + H(+) + NADPH"}
{"X":46007,"RHEA_ID":54388,"compounds":"1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate"}
{"X":46008,"RHEA_ID":54389,"compounds":"1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O => 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate"}
{"X":46009,"RHEA_ID":47700,"compounds":"H(+) + ketocytochalasin + NADPH + O2 = H2O + iso-precytochalasin + NADP(+)"}
{"X":46010,"RHEA_ID":44407,"compounds":"3-demethylubiquinol-7 + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + ubiquinol-7"}
{"X":46011,"RHEA_ID":54392,"compounds":"1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":46012,"RHEA_ID":54393,"compounds":"1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O => (9Z,12Z)-octadecadienoate + 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":46013,"RHEA_ID":54394,"compounds":"(9Z,12Z)-octadecadienoate + 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O"}
{"X":46014,"RHEA_ID":44411,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O <=> a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)"}
{"X":46015,"RHEA_ID":54396,"compounds":"1-tetradecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate"}
{"X":46016,"RHEA_ID":54397,"compounds":"1-tetradecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate"}
{"X":46017,"RHEA_ID":54398,"compounds":"2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate => 1-tetradecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O"}
{"X":46018,"RHEA_ID":44415,"compounds":"3-demethylubiquinol-10 + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + ubiquinol-10"}
{"X":46019,"RHEA_ID":54400,"compounds":"1-tetradecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate"}
{"X":46020,"RHEA_ID":44417,"compounds":"1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+)"}
{"X":46021,"RHEA_ID":54402,"compounds":"2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate => 1-tetradecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O"}
{"X":46022,"RHEA_ID":44419,"compounds":"1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+)"}
{"X":46023,"RHEA_ID":54404,"compounds":"1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O = 2-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate"}
{"X":46024,"RHEA_ID":54405,"compounds":"1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O => 2-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate"}
{"X":46025,"RHEA_ID":54406,"compounds":"2-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate => 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":46026,"RHEA_ID":44423,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphate + H2O <=> a 1-acyl-sn-glycero-3-phosphate + a fatty acid + H(+)"}
{"X":46027,"RHEA_ID":44424,"compounds":"an acyl-CoA + heptadecasphing-4-enine = CoA + H(+) + N-acyl-heptadecasphing-4-enine"}
{"X":46028,"RHEA_ID":54409,"compounds":"1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)"}
{"X":46029,"RHEA_ID":54410,"compounds":"1-octadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O"}
{"X":46030,"RHEA_ID":44427,"compounds":"an acyl-CoA + heptadecasphing-4-enine <=> CoA + H(+) + N-acyl-heptadecasphing-4-enine"}
{"X":46031,"RHEA_ID":54412,"compounds":"a 3-oxo-5beta-steroid + NADP(+) = a 3-oxo-Delta(4)-steroid + H(+) + NADPH"}
{"X":46032,"RHEA_ID":54413,"compounds":"a 3-oxo-5beta-steroid + NADP(+) => a 3-oxo-Delta(4)-steroid + H(+) + NADPH"}
{"X":46033,"RHEA_ID":54414,"compounds":"a 3-oxo-Delta(4)-steroid + H(+) + NADPH => a 3-oxo-5beta-steroid + NADP(+)"}
{"X":46034,"RHEA_ID":44431,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + glycerol <=> a 1-acyl-sn-glycero-3-phosphocholine + a 1-acylglycerol"}
{"X":46035,"RHEA_ID":54416,"compounds":"5alpha-campestan-3-one + NADP(+) = campest-4-en-3-one + H(+) + NADPH"}
{"X":46036,"RHEA_ID":54417,"compounds":"5alpha-campestan-3-one + NADP(+) => campest-4-en-3-one + H(+) + NADPH"}
{"X":46037,"RHEA_ID":54418,"DIRECTION":"RL","MASTER_ID":54416,"metacyc":"RXN-711","compounds":"campest-4-en-3-one + H(+) + NADPH => 5alpha-campestan-3-one + NADP(+)"}
{"X":46038,"RHEA_ID":44435,"compounds":"2 a 1-acylglycerol <=> a 1,2-diacylglycerol + glycerol"}
{"X":46039,"RHEA_ID":54420,"DIRECTION":"UN","MASTER_ID":54420,"ec":"3.1.4.59","compounds":"3',3'-c-di-AMP + H2O = 5'-O-phosphonoadenylyl-(3'->5')-adenosine + H(+)"}
{"X":46040,"RHEA_ID":54421,"DIRECTION":"LR","MASTER_ID":54420,"metacyc":"RXN-19814","compounds":"3',3'-c-di-AMP + H2O => 5'-O-phosphonoadenylyl-(3'->5')-adenosine + H(+)"}
{"X":46041,"RHEA_ID":54422,"compounds":"5'-O-phosphonoadenylyl-(3'->5')-adenosine + H(+) => 3',3'-c-di-AMP + H2O"}
{"X":46042,"RHEA_ID":44439,"compounds":"a 1,2-diacylglycerol + a 1-acylglycerol <=> a triacylglycerol + glycerol"}
{"X":46043,"RHEA_ID":44440,"compounds":"a 1,3-diacylglycerol + a 1-acylglycerol = a triacylglycerol + glycerol"}
{"X":46044,"RHEA_ID":54425,"compounds":"L-aspartyl-[protein] + NAD(+) => 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide"}
{"X":46045,"RHEA_ID":54426,"compounds":"4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide => L-aspartyl-[protein] + NAD(+)"}
{"X":46046,"RHEA_ID":44443,"compounds":"a 1,3-diacylglycerol + a 1-acylglycerol <=> a triacylglycerol + glycerol"}
{"X":46047,"RHEA_ID":54428,"compounds":"4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + H2O = ADP-D-ribose + H(+) + L-aspartyl-[protein]"}
{"X":46048,"RHEA_ID":44445,"compounds":"a 1,2-diacylglycerol + H2O => a fatty acid + a monoacylglycerol + H(+)"}
{"X":46049,"RHEA_ID":44446,"compounds":"a fatty acid + a monoacylglycerol + H(+) => a 1,2-diacylglycerol + H2O"}
{"X":46050,"RHEA_ID":44447,"compounds":"a 1,2-diacylglycerol + H2O <=> a fatty acid + a monoacylglycerol + H(+)"}
{"X":46051,"RHEA_ID":44448,"compounds":"an acyl-CoA + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + CoA"}
{"X":46052,"RHEA_ID":54433,"DIRECTION":"LR","MASTER_ID":54432,"metacyc":"RXN-18385","compounds":"2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2 => a 4-H-anthocyanidin with a 3-hydroxy group + CO2 + 2 H2O + succinate"}
{"X":46053,"RHEA_ID":44450,"compounds":"a 3-oxoacyl-[ACP] + CO2 + CoA => an acyl-CoA + H(+) + malonyl-[ACP]"}
{"X":46054,"RHEA_ID":44451,"compounds":"an acyl-CoA + H(+) + malonyl-[ACP] <=> a 3-oxoacyl-[ACP] + CO2 + CoA"}
{"X":46055,"RHEA_ID":54436,"compounds":"2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2 = a (4S)-2,3-dehydroflavan-3,4-diol + CO2 + H(+) + H2O + succinate"}
{"X":46056,"RHEA_ID":54437,"DIRECTION":"LR","MASTER_ID":54436,"metacyc":"RXN-18348","compounds":"2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2 => a (4S)-2,3-dehydroflavan-3,4-diol + CO2 + H(+) + H2O + succinate"}
{"X":46057,"RHEA_ID":54438,"compounds":"a (4S)-2,3-dehydroflavan-3,4-diol + CO2 + H(+) + H2O + succinate => 2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2"}
{"X":46058,"RHEA_ID":54439,"compounds":"2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2 <=> a (4S)-2,3-dehydroflavan-3,4-diol + CO2 + H(+) + H2O + succinate"}
{"X":46059,"RHEA_ID":54440,"compounds":"a (4S)-2,3-dehydroflavan-3,4-diol + H(+) = a 4-H-anthocyanidin with a 3-hydroxy group + H2O"}
{"X":46060,"RHEA_ID":54441,"DIRECTION":"LR","MASTER_ID":54440,"metacyc":"RXN-18349","compounds":"a (4S)-2,3-dehydroflavan-3,4-diol + H(+) => a 4-H-anthocyanidin with a 3-hydroxy group + H2O"}
{"X":46061,"RHEA_ID":54442,"compounds":"a 4-H-anthocyanidin with a 3-hydroxy group + H2O => a (4S)-2,3-dehydroflavan-3,4-diol + H(+)"}
{"X":46062,"RHEA_ID":44459,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine <=> 1-O-acyl-N-acylsphingosine + a 1-acyl-sn-glycero-3-phosphocholine"}
{"X":46063,"RHEA_ID":54444,"DIRECTION":"UN","MASTER_ID":54444,"ec":"1.1.1.219","compounds":"a (2R,3S,4S)-leucoanthocyanidin + NADP(+) = a (2R,3R)-dihydroflavonol + H(+) + NADPH"}
{"X":46064,"RHEA_ID":54445,"compounds":"a (2R,3S,4S)-leucoanthocyanidin + NADP(+) => a (2R,3R)-dihydroflavonol + H(+) + NADPH"}
{"X":46065,"RHEA_ID":44462,"compounds":"a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycerol"}
{"X":46066,"RHEA_ID":44463,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycerol <=> a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine"}
{"X":46067,"RHEA_ID":54448,"DIRECTION":"UN","MASTER_ID":54448,"ec":"3.1.1.29","compounds":"H2O + N-acyl-L-alpha-aminoacyl-tRNA = an N-acyl-L-amino acid + H(+) + tRNA"}
{"X":46068,"RHEA_ID":44465,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol => 1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine"}
{"X":46069,"RHEA_ID":44466,"compounds":"1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol"}
{"X":46070,"RHEA_ID":44467,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol <=> 1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine"}
{"X":46071,"RHEA_ID":54452,"compounds":"a 5,6-dihydrouridine in tRNA + NAD(+) = a uridine in tRNA + H(+) + NADH"}
{"X":46072,"RHEA_ID":54453,"compounds":"a 5,6-dihydrouridine in tRNA + NAD(+) => a uridine in tRNA + H(+) + NADH"}
{"X":46073,"RHEA_ID":44470,"compounds":"1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine => 3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine"}
{"X":46074,"RHEA_ID":44471,"compounds":"3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine <=> 1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine"}
{"X":46075,"RHEA_ID":44472,"compounds":"1-O-alkylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-alkyl-3-acylglycerol + a monoacyl-sn-glycero-3-phosphocholine"}
{"X":46076,"RHEA_ID":44473,"compounds":"1-O-alkylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine => 1-O-alkyl-3-acylglycerol + a monoacyl-sn-glycero-3-phosphocholine"}
{"X":46077,"RHEA_ID":54458,"compounds":"1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate => 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":46078,"RHEA_ID":44475,"compounds":"1-O-alkylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine <=> 1-O-alkyl-3-acylglycerol + a monoacyl-sn-glycero-3-phosphocholine"}
{"X":46079,"RHEA_ID":54460,"compounds":"1-octadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate"}
{"X":46080,"RHEA_ID":54461,"compounds":"1-octadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate"}
{"X":46081,"RHEA_ID":54462,"compounds":"1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate => 1-octadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":46082,"RHEA_ID":44479,"compounds":"1-O-alkyl-2-acetylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine <=> a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine"}
{"X":46083,"RHEA_ID":54464,"compounds":"1-octadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexanoate"}
{"X":46084,"RHEA_ID":54465,"compounds":"1-octadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexanoate"}
{"X":46085,"RHEA_ID":44482,"compounds":"3-methoxy-4-hydroxy-5-all-trans-heptaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine => 3,4-dihydroxy-5-all-trans-heptaprenylbenzoate + S-adenosyl-L-methionine"}
{"X":46086,"RHEA_ID":44483,"compounds":"3,4-dihydroxy-5-all-trans-heptaprenylbenzoate + S-adenosyl-L-methionine <=> 3-methoxy-4-hydroxy-5-all-trans-heptaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine"}
{"X":46087,"RHEA_ID":54468,"compounds":"1-octadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + octanoate"}
{"X":46088,"RHEA_ID":54469,"compounds":"1-octadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + octanoate"}
{"X":46089,"RHEA_ID":44486,"compounds":"3-methoxy-4-hydroxy-5-all-trans-octaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine => 3,4-dihydroxy-5-all-trans-octaprenylbenzoate + S-adenosyl-L-methionine"}
{"X":46090,"RHEA_ID":44487,"compounds":"3,4-dihydroxy-5-all-trans-octaprenylbenzoate + S-adenosyl-L-methionine <=> 3-methoxy-4-hydroxy-5-all-trans-octaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine"}
{"X":46091,"RHEA_ID":54472,"compounds":"1-octadecanoyl-2-nonanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanoate"}
{"X":46092,"RHEA_ID":44489,"DIRECTION":"LR","MASTER_ID":44488,"metacyc":"RXN-9281","compounds":"3,4-dihydroxy-5-all-trans-nonaprenylbenzoate + S-adenosyl-L-methionine => 3-methoxy-4-hydroxy-5-all-trans-nonaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine"}
{"X":46093,"RHEA_ID":44490,"compounds":"3-methoxy-4-hydroxy-5-all-trans-nonaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine => 3,4-dihydroxy-5-all-trans-nonaprenylbenzoate + S-adenosyl-L-methionine"}
{"X":46094,"RHEA_ID":44491,"compounds":"3,4-dihydroxy-5-all-trans-nonaprenylbenzoate + S-adenosyl-L-methionine <=> 3-methoxy-4-hydroxy-5-all-trans-nonaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine"}
{"X":46095,"RHEA_ID":57820,"compounds":"[phosphate](n) + ADP = [phosphate](n+1) + AMP"}
{"X":46096,"RHEA_ID":54477,"compounds":"1-octadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + dodecanoate + H(+)"}
{"X":46097,"RHEA_ID":44494,"compounds":"3-methoxy-4-hydroxy-5-all-trans-decaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine => 3,4-dihydroxy-5-all-trans-decaprenylbenzoate + S-adenosyl-L-methionine"}
{"X":46098,"RHEA_ID":44495,"compounds":"3,4-dihydroxy-5-all-trans-decaprenylbenzoate + S-adenosyl-L-methionine <=> 3-methoxy-4-hydroxy-5-all-trans-decaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine"}
{"X":46099,"RHEA_ID":54480,"compounds":"1-octadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate"}
{"X":46100,"RHEA_ID":54481,"compounds":"1-octadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate"}
{"X":46101,"RHEA_ID":44498,"compounds":"2-(acylamino)ethyl fatty acid + a monoacyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylethanolamine"}
{"X":46102,"RHEA_ID":44499,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylethanolamine <=> 2-(acylamino)ethyl fatty acid + a monoacyl-sn-glycero-3-phosphocholine"}
{"X":46103,"RHEA_ID":57828,"compounds":"dIMP + H2O = 2-deoxy-D-ribose 5-phosphate + hypoxanthine"}
{"X":46104,"RHEA_ID":44501,"compounds":"1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoserine + H(+)"}
{"X":46105,"RHEA_ID":44502,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoserine + H(+) => 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserine + H2O"}
{"X":46106,"RHEA_ID":44503,"compounds":"1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoserine + H(+)"}
{"X":46107,"RHEA_ID":57832,"compounds":"5-oxopentanoate + H2O + NADP(+) = glutarate + 2 H(+) + NADPH"}
{"X":46108,"RHEA_ID":44505,"compounds":"4-hydroxybenzoate + an all-trans-polyprenyl diphosphate => a 4-hydroxy-3-all-trans-polyprenylbenzoate + diphosphate"}
{"X":46109,"RHEA_ID":44506,"compounds":"a 4-hydroxy-3-all-trans-polyprenylbenzoate + diphosphate => 4-hydroxybenzoate + an all-trans-polyprenyl diphosphate"}
{"X":46110,"RHEA_ID":57836,"compounds":"H2O + O2 + thermospermine = 3-aminopropanal + H2O2 + spermidine"}
{"X":46111,"RHEA_ID":54493,"compounds":"1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine => 1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphoethanolamine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine"}
{"X":46112,"RHEA_ID":44510,"compounds":"1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}
{"X":46113,"RHEA_ID":44511,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine"}
{"X":46114,"RHEA_ID":57840,"compounds":"1D-myo-inositol 1,3-bisphosphate + H2O = 1D-myo-inositol 1-phosphate + phosphate"}
{"X":46115,"RHEA_ID":54497,"DIRECTION":"LR","MASTER_ID":54496,"metacyc":"RXN-18890","compounds":"ent-copalyl diphosphate => diphosphate + ent-atiserene"}
{"X":46116,"RHEA_ID":44514,"compounds":"1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}
{"X":46117,"RHEA_ID":44515,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphocholine"}
{"X":46118,"RHEA_ID":57843,"compounds":"1D-myo-inositol 1,3-bisphosphate + H2O <=> 1D-myo-inositol 1-phosphate + phosphate"}
{"X":46119,"RHEA_ID":54501,"DIRECTION":"LR","MASTER_ID":54500,"metacyc":"RXN-18978","compounds":"(2E,6E,10E,14E)-geranylfarnesyl diphosphate => beta-geranylfarnesene + diphosphate"}
{"X":46120,"RHEA_ID":44518,"compounds":"(9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphoserine + H(+) => 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoserine + H2O"}
{"X":46121,"RHEA_ID":44519,"compounds":"1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoserine + H2O <=> (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphoserine + H(+)"}
{"X":46122,"RHEA_ID":57847,"compounds":"fraxetin + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sideretin (reduced form)"}
{"X":46123,"RHEA_ID":54505,"DIRECTION":"LR","MASTER_ID":54504,"metacyc":"RXN-18979","compounds":"all-trans-hexaprenyl diphosphate => beta-hexaprene + diphosphate"}
{"X":46124,"RHEA_ID":44522,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O"}
{"X":46125,"RHEA_ID":44523,"compounds":"1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":46126,"RHEA_ID":44524,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-glycerol + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-glycerol + H(+)"}
{"X":46127,"RHEA_ID":47819,"compounds":"H(+) + N(6)-(dimethylallyl)adenosine 5'-diphosphate + NADPH + O2 <=> 9-ribosyl-trans-zeatin 5'-diphosphate + H2O + NADP(+)"}
{"X":46128,"RHEA_ID":44526,"compounds":"(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-glycerol + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-glycerol + H2O"}
{"X":46129,"RHEA_ID":44527,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-glycerol + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-glycerol + H(+)"}
{"X":46130,"RHEA_ID":44528,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+)"}
{"X":46131,"RHEA_ID":47823,"compounds":"H(+) + N(6)-(dimethylallyl)adenosine 5'-triphosphate + NADPH + O2 <=> 9-ribosyl-trans-zeatin 5'-triphosphate + H2O + NADP(+)"}
{"X":46132,"RHEA_ID":44530,"compounds":"(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O"}
{"X":46133,"RHEA_ID":44531,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+)"}
{"X":46134,"RHEA_ID":44532,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphoethanolamine"}
{"X":46135,"RHEA_ID":57860,"compounds":"(E)-6-hydroxyferuloyl-CoA = CoA + scopoletin"}
{"X":46136,"RHEA_ID":44534,"compounds":"1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine"}
{"X":46137,"RHEA_ID":44535,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphoethanolamine"}
{"X":46138,"RHEA_ID":44536,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphoethanolamine"}
{"X":46139,"RHEA_ID":57864,"DIRECTION":"UN","MASTER_ID":57864,"ec":"1.14.14.165","compounds":"indole-3-carbonyl nitrile + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxy-indole-3-carbonyl nitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":46140,"RHEA_ID":44538,"compounds":"1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine"}
{"X":46141,"RHEA_ID":44539,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphoethanolamine"}
{"X":46142,"RHEA_ID":44540,"compounds":"1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)"}
{"X":46143,"RHEA_ID":57868,"DIRECTION":"UN","MASTER_ID":57868,"ec":"1.14.11.62","compounds":"(E)-4-coumaroyl-CoA + 2-oxoglutarate + O2 = (E)-2,4-dihydroxycinnamoyl-CoA + CO2 + succinate"}
{"X":46144,"RHEA_ID":44542,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) => 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O"}
{"X":46145,"RHEA_ID":44543,"compounds":"1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)"}
{"X":46146,"RHEA_ID":44544,"compounds":"a fatty acid(out) + ATP + H2O = a fatty acid(in) + ADP + H(+) + phosphate"}
{"X":46147,"RHEA_ID":44545,"compounds":"a fatty acid(out) + ATP + H2O => a fatty acid(in) + ADP + H(+) + phosphate"}
{"X":46148,"RHEA_ID":44546,"compounds":"a fatty acid(in) + ADP + H(+) + phosphate => a fatty acid(out) + ATP + H2O"}
{"X":46149,"RHEA_ID":44547,"compounds":"a fatty acid(out) + ATP + H2O <=> a fatty acid(in) + ADP + H(+) + phosphate"}
{"X":46150,"RHEA_ID":54532,"DIRECTION":"UN","MASTER_ID":54532,"ec":"3.5.1.128","compounds":"H2O + N-(4-oxoglutaryl)-L-cysteinylglycine = 2-oxoglutarate + L-cysteinylglycine"}
{"X":46151,"RHEA_ID":54533,"DIRECTION":"LR","MASTER_ID":54532,"metacyc":"RXN-18696","compounds":"H2O + N-(4-oxoglutaryl)-L-cysteinylglycine => 2-oxoglutarate + L-cysteinylglycine"}
{"X":46152,"RHEA_ID":54534,"compounds":"2-oxoglutarate + L-cysteinylglycine => H2O + N-(4-oxoglutaryl)-L-cysteinylglycine"}
{"X":46153,"RHEA_ID":44551,"compounds":"an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an (omega-1)-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":46154,"RHEA_ID":54536,"compounds":"a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate"}
{"X":46155,"RHEA_ID":54537,"DIRECTION":"LR","MASTER_ID":54536,"metacyc":"RXN-16415","compounds":"a very long-chain fatty acid + ATP + CoA => a very long-chain fatty acyl-CoA + AMP + diphosphate"}
{"X":46156,"RHEA_ID":54538,"compounds":"a very long-chain fatty acyl-CoA + AMP + diphosphate => a very long-chain fatty acid + ATP + CoA"}
{"X":46157,"RHEA_ID":44555,"compounds":"1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H2O <=> H(+) + hexadecanoate + sn-glycero-3-phospho-L-serine"}
{"X":46158,"RHEA_ID":54540,"DIRECTION":"UN","MASTER_ID":54540,"ec":"3.2.1.97","compounds":"H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] = beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-threonyl-[protein]"}
{"X":46159,"RHEA_ID":54541,"DIRECTION":"LR","MASTER_ID":54540,"metacyc":"3.2.1.97-RXN","compounds":"H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] => beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-threonyl-[protein]"}
{"X":46160,"RHEA_ID":44558,"compounds":"4-hydroxy-3-all-trans-hexaprenylbenzoate + diphosphate => 4-hydroxybenzoate + all-trans-hexaprenyl diphosphate"}
{"X":46161,"RHEA_ID":54544,"compounds":"1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine + 2-heptanoyl-sn-glycero-3-phosphocholine = 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine + hexanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":46162,"RHEA_ID":54545,"compounds":"1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine + 2-heptanoyl-sn-glycero-3-phosphocholine => 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine + hexanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":46163,"RHEA_ID":44562,"compounds":"4-hydroxy-3-all-trans-heptaprenylbenzoate + diphosphate => 4-hydroxybenzoate + all-trans-heptaprenyl diphosphate"}
{"X":46164,"RHEA_ID":44563,"compounds":"4-hydroxybenzoate + all-trans-heptaprenyl diphosphate <=> 4-hydroxy-3-all-trans-heptaprenylbenzoate + diphosphate"}
{"X":46165,"RHEA_ID":54548,"compounds":"D-xylulose 1,5-bisphosphate + H2O = D-xylulose 5-phosphate + phosphate"}
{"X":46166,"RHEA_ID":54549,"compounds":"D-xylulose 1,5-bisphosphate + H2O => D-xylulose 5-phosphate + phosphate"}
{"X":46167,"RHEA_ID":44566,"compounds":"4-hydroxy-3-all-trans-decaprenylbenzoate + diphosphate => 4-hydroxybenzoate + all-trans-decaprenyl diphosphate"}
{"X":46168,"RHEA_ID":44567,"compounds":"4-hydroxybenzoate + all-trans-decaprenyl diphosphate <=> 4-hydroxy-3-all-trans-decaprenylbenzoate + diphosphate"}
{"X":46169,"RHEA_ID":54552,"compounds":"1-O-hexadecyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate"}
{"X":46170,"RHEA_ID":54553,"compounds":"1-O-hexadecyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate"}
{"X":46171,"RHEA_ID":54554,"compounds":"1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate => 1-O-hexadecyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O"}
{"X":46172,"RHEA_ID":44571,"compounds":"4-hydroxy-3-all-trans-hexaprenylbenzoate + H(+) <=> 2-all-trans-hexaprenylphenol + CO2"}
{"X":46173,"RHEA_ID":54556,"compounds":"5'-end ribonucleotide-tRNA(His) + ATP + H(+) = an adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + diphosphate"}
{"X":46174,"RHEA_ID":54557,"DIRECTION":"LR","MASTER_ID":54556,"metacyc":"RXN-12503","compounds":"5'-end ribonucleotide-tRNA(His) + ATP + H(+) => an adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + diphosphate"}
{"X":46175,"RHEA_ID":54558,"compounds":"an adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + diphosphate => 5'-end ribonucleotide-tRNA(His) + ATP + H(+)"}
{"X":46176,"RHEA_ID":44575,"compounds":"4-hydroxy-3-all-trans-heptaprenylbenzoate + H(+) <=> 2-all-trans-heptaprenylphenol + CO2"}
{"X":46177,"RHEA_ID":54560,"compounds":"an adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + GTP = a 5'-triphospho-guanosine-ribonucleotide-tRNA(His) + AMP + H(+)"}
{"X":46178,"RHEA_ID":54561,"DIRECTION":"LR","MASTER_ID":54560,"metacyc":"RXN-12504","compounds":"an adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + GTP => a 5'-triphospho-guanosine-ribonucleotide-tRNA(His) + AMP + H(+)"}
{"X":46179,"RHEA_ID":54562,"compounds":"a 5'-triphospho-guanosine-ribonucleotide-tRNA(His) + AMP + H(+) => an adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + GTP"}
{"X":46180,"RHEA_ID":44579,"compounds":"4-hydroxy-3-all-trans-nonaprenylbenzoate + H(+) <=> 2-all-trans-nonaprenylphenol + CO2"}
{"X":46181,"RHEA_ID":54564,"DIRECTION":"UN","MASTER_ID":54564,"ec":"2.7.7.79","compounds":"5'-end ribonucleotide-tRNA(His) + ATP + GTP + H2O = a 5'-phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)"}
{"X":46182,"RHEA_ID":54565,"DIRECTION":"LR","MASTER_ID":54564,"metacyc":"RXN-12502","compounds":"5'-end ribonucleotide-tRNA(His) + ATP + GTP + H2O => a 5'-phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)"}
{"X":46183,"RHEA_ID":54566,"compounds":"a 5'-phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+) => 5'-end ribonucleotide-tRNA(His) + ATP + GTP + H2O"}
{"X":46184,"RHEA_ID":44583,"compounds":"4-hydroxy-3-all-trans-decaprenylbenzoate + H(+) <=> 2-all-trans-decaprenylphenol + CO2"}
{"X":46185,"RHEA_ID":54568,"compounds":"a uridine in rRNA = a pseudouridine in rRNA"}
{"X":46186,"RHEA_ID":54569,"compounds":"a uridine in rRNA => a pseudouridine in rRNA"}
{"X":46187,"RHEA_ID":54570,"compounds":"a pseudouridine in rRNA => a uridine in rRNA"}
{"X":46188,"RHEA_ID":44587,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-(1'-sn-glycerol)"}
{"X":46189,"RHEA_ID":54572,"compounds":"a uridine in tRNA = a pseudouridine in tRNA"}
{"X":46190,"RHEA_ID":54573,"compounds":"a uridine in tRNA => a pseudouridine in tRNA"}
{"X":46191,"RHEA_ID":44590,"compounds":"(9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-1D-myo-inositol => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O"}
{"X":46192,"RHEA_ID":44591,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-1D-myo-inositol"}
{"X":46193,"RHEA_ID":54576,"compounds":"2-oxoglutarate + an N(1)-methyladenosine in tRNA + O2 = an adenosine in tRNA + CO2 + formaldehyde + succinate"}
{"X":46194,"RHEA_ID":54577,"compounds":"2-oxoglutarate + an N(1)-methyladenosine in tRNA + O2 => an adenosine in tRNA + CO2 + formaldehyde + succinate"}
{"X":46195,"RHEA_ID":54578,"compounds":"an adenosine in tRNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + an N(1)-methyladenosine in tRNA + O2"}
{"X":46196,"RHEA_ID":44595,"compounds":"3-(all-trans-heptaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> 2-methoxy-6-(all-trans-heptaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine"}
{"X":46197,"RHEA_ID":54580,"DIRECTION":"UN","MASTER_ID":54580,"ec":"2.7.1.78","compounds":"5'-dephospho-(RNA) + ATP = 5'-end-(RNA) + ADP + H(+)"}
{"X":46198,"RHEA_ID":57924,"compounds":"H2O + mutildienyl diphosphate = diphosphate + premutilin"}
{"X":46199,"RHEA_ID":54582,"compounds":"5'-end-(RNA) + ADP + H(+) => 5'-dephospho-(RNA) + ATP"}
{"X":46200,"RHEA_ID":44599,"compounds":"a fatty acyl-[ACP] + H2O <=> a fatty acid + H(+) + holo-[ACP]"}
{"X":46201,"RHEA_ID":54584,"compounds":"a guanosine in 18S rRNA + S-adenosyl-L-methionine = an N(7)-methylguanosine in 18S rRNA + S-adenosyl-L-homocysteine"}
{"X":46202,"RHEA_ID":57928,"DIRECTION":"UN","MASTER_ID":57928,"ec":"6.3.5.13","compounds":"ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + H2O + L-glutamine = ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + H(+) + L-glutamate + phosphate"}
{"X":46203,"RHEA_ID":54586,"compounds":"an N(7)-methylguanosine in 18S rRNA + S-adenosyl-L-homocysteine => a guanosine in 18S rRNA + S-adenosyl-L-methionine"}
{"X":46204,"RHEA_ID":44603,"compounds":"a fatty acid + ATP + H(+) <=> a fatty acyl-AMP + diphosphate"}
{"X":46205,"RHEA_ID":44604,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)"}
{"X":46206,"RHEA_ID":44605,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O => a 1-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)"}
{"X":46207,"RHEA_ID":44606,"compounds":"a 1-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O"}
{"X":46208,"RHEA_ID":44607,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O <=> a 1-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)"}
{"X":46209,"RHEA_ID":44608,"DIRECTION":"UN","MASTER_ID":44608,"ec":"2.1.1.222","compounds":"3-(all-trans-nonaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = 2-methoxy-6-(all-trans-nonaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine"}
{"X":46210,"RHEA_ID":44609,"DIRECTION":"LR","MASTER_ID":44608,"metacyc":"RXN-9240","compounds":"3-(all-trans-nonaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine => 2-methoxy-6-(all-trans-nonaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine"}
{"X":46211,"RHEA_ID":54594,"compounds":"a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + diphosphate => a 5'-end diphospho-(purine-ribonucleoside) in mRNA + GTP + H(+)"}
{"X":46212,"RHEA_ID":44611,"compounds":"3-(all-trans-nonaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> 2-methoxy-6-(all-trans-nonaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine"}
{"X":46213,"RHEA_ID":44612,"DIRECTION":"UN","MASTER_ID":44612,"ec":"2.1.1.222","compounds":"3-(all-trans-decaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = 2-methoxy-6-(all-trans-decaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine"}
{"X":46214,"RHEA_ID":54597,"compounds":"2-oxoglutarate + hexadecanoyl-CoA + O2 => 2-hydroxyhexadecanoyl-CoA + CO2 + succinate"}
{"X":46215,"RHEA_ID":54598,"compounds":"2-hydroxyhexadecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + hexadecanoyl-CoA + O2"}
{"X":46216,"RHEA_ID":44615,"compounds":"3-(all-trans-decaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> 2-methoxy-6-(all-trans-decaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine"}
{"X":46217,"RHEA_ID":44616,"compounds":"1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + H2O = 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+)"}
{"X":46218,"RHEA_ID":54601,"compounds":"2-oxoglutarate + O2 + octanoyl-CoA => 2-hydroxyoctanoyl-CoA + CO2 + succinate"}
{"X":46219,"RHEA_ID":44618,"compounds":"1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+) => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + H2O"}
{"X":46220,"RHEA_ID":44619,"compounds":"1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + H2O <=> 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+)"}
{"X":46221,"RHEA_ID":54604,"compounds":"2-oxoglutarate + decanoyl-CoA + O2 = 2-hydroxydecanoyl-CoA + CO2 + succinate"}
{"X":46222,"RHEA_ID":44621,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphinganine => a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphocholine"}
{"X":46223,"RHEA_ID":44622,"compounds":"a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphinganine"}
{"X":46224,"RHEA_ID":44623,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphinganine <=> a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphocholine"}
{"X":46225,"RHEA_ID":54608,"compounds":"a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] = a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + L-lysyl-[protein]"}
{"X":46226,"RHEA_ID":54609,"compounds":"a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] => a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + L-lysyl-[protein]"}
{"X":46227,"RHEA_ID":54610,"compounds":"a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + L-lysyl-[protein] => a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein]"}
{"X":46228,"RHEA_ID":54611,"compounds":"a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] <=> a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + L-lysyl-[protein]"}
{"X":46229,"RHEA_ID":54612,"compounds":"2-oxoglutarate + 3-methylbutanoyl-CoA + O2 = 2-hydroxy-3-methylbutanoyl-CoA + CO2 + succinate"}
{"X":46230,"RHEA_ID":44629,"DIRECTION":"LR","MASTER_ID":44628,"metacyc":"RXN-16285","compounds":"L-dihydroanticapsin + NAD(+) => H(+) + L-anticapsin + NADH"}
{"X":46231,"RHEA_ID":54614,"compounds":"2-hydroxy-3-methylbutanoyl-CoA + CO2 + succinate => 2-oxoglutarate + 3-methylbutanoyl-CoA + O2"}
{"X":46232,"RHEA_ID":54615,"compounds":"2-oxoglutarate + 3-methylbutanoyl-CoA + O2 <=> 2-hydroxy-3-methylbutanoyl-CoA + CO2 + succinate"}
{"X":46233,"RHEA_ID":54616,"compounds":"2-oxoglutarate + heptadecanoyl-CoA + O2 = 2-hydroxyheptadecanoyl-CoA + CO2 + succinate"}
{"X":46234,"RHEA_ID":44633,"DIRECTION":"LR","MASTER_ID":44632,"metacyc":"RXN-16269","compounds":"(3,5-dihydroxyphenyl)acetyl-CoA + O2 => 2-(3,5-dihydroxyphenyl)-2-oxoacetate + CoA + H(+)"}
{"X":46235,"RHEA_ID":47928,"DIRECTION":"UN","MASTER_ID":47928,"ec":"1.2.1.97","compounds":"(S)-3-sulfolactaldehyde + H2O + NADP(+) = (S)-3-sulfolactate + 2 H(+) + NADPH"}
{"X":46236,"RHEA_ID":54619,"compounds":"2-oxoglutarate + heptadecanoyl-CoA + O2 <=> 2-hydroxyheptadecanoyl-CoA + CO2 + succinate"}
{"X":46237,"RHEA_ID":44636,"DIRECTION":"UN","MASTER_ID":44636,"ec":"3.3.2.14","compounds":"2,4-dinitroanisole + H2O = 2,4-dinitrophenol + H(+) + methanol"}
{"X":46238,"RHEA_ID":44637,"DIRECTION":"LR","MASTER_ID":44636,"metacyc":"RXN-16303","compounds":"2,4-dinitroanisole + H2O => 2,4-dinitrophenol + H(+) + methanol"}
{"X":46239,"RHEA_ID":54622,"compounds":"2-hydroxyeicosanoyl-CoA + CO2 + succinate => 2-oxoglutarate + eicosanoyl-CoA + O2"}
{"X":46240,"RHEA_ID":54623,"compounds":"2-oxoglutarate + eicosanoyl-CoA + O2 <=> 2-hydroxyeicosanoyl-CoA + CO2 + succinate"}
{"X":46241,"RHEA_ID":44640,"DIRECTION":"UN","MASTER_ID":44640,"ec":"2.7.4.6","compounds":"a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP"}
{"X":46242,"RHEA_ID":44641,"DIRECTION":"LR","MASTER_ID":44640,"ecocyc":"NUCLEOSIDE-DIP-KIN-RXN","metacyc":"NUCLEOSIDE-DIP-KIN-RXN","compounds":"a 2'-deoxyribonucleoside 5'-diphosphate + ATP => a 2'-deoxyribonucleoside 5'-triphosphate + ADP"}
{"X":46243,"RHEA_ID":47936,"DIRECTION":"UN","MASTER_ID":47936,"ec":"1.2.1.96","compounds":"4-hydroxybenzaldehyde + H2O + NADP(+) = 4-hydroxybenzoate + 2 H(+) + NADPH"}
{"X":46244,"RHEA_ID":44643,"compounds":"a 2'-deoxyribonucleoside 5'-diphosphate + ATP <=> a 2'-deoxyribonucleoside 5'-triphosphate + ADP"}
{"X":46245,"RHEA_ID":44644,"DIRECTION":"UN","MASTER_ID":44644,"ec":"3.6.1.9","compounds":"a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)"}
{"X":46246,"RHEA_ID":44645,"DIRECTION":"LR","MASTER_ID":44644,"ecocyc":"3.6.1.19-RXN","metacyc":"3.6.1.19-RXN","compounds":"a 2'-deoxyribonucleoside 5'-triphosphate + H2O => a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)"}
{"X":46247,"RHEA_ID":47940,"compounds":"ganglioside GM2 (d18:1(4E)) + H2O = ganglioside GM3 (d18:1(4E)) + N-acetyl-beta-D-galactosamine"}
{"X":46248,"RHEA_ID":44647,"compounds":"a 2'-deoxyribonucleoside 5'-triphosphate + H2O <=> a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)"}
{"X":46249,"RHEA_ID":44648,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 2-acyl-sn-glycerol 3-phosphate + a fatty acid + H(+)"}
{"X":46250,"RHEA_ID":44649,"DIRECTION":"LR","MASTER_ID":44648,"metacyc":"RXN-20541","compounds":"a 1,2-diacyl-sn-glycero-3-phosphate + H2O => a 2-acyl-sn-glycerol 3-phosphate + a fatty acid + H(+)"}
{"X":46251,"RHEA_ID":54634,"compounds":"2-hydroxytetradecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + O2 + tetradecanoyl-CoA"}
{"X":46252,"RHEA_ID":44651,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphate + H2O <=> a 2-acyl-sn-glycerol 3-phosphate + a fatty acid + H(+)"}
{"X":46253,"RHEA_ID":44652,"compounds":"a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a 1-acyl-sn-glycero-3-phosphocholine = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine"}
{"X":46254,"RHEA_ID":44653,"compounds":"a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine"}
{"X":46255,"RHEA_ID":54638,"compounds":"diphosphate + labda-7,13(16),14-triene => (13E)-labda-7,13-dien-15-yl diphosphate"}
{"X":46256,"RHEA_ID":44655,"compounds":"a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a 1-acyl-sn-glycero-3-phosphocholine <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine"}
{"X":46257,"RHEA_ID":44656,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a monoacyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine"}
{"X":46258,"RHEA_ID":44657,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine => a monoacyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine"}
{"X":46259,"RHEA_ID":54642,"compounds":"(12E)-labda-8(17),12,14-triene + diphosphate => (+)-copalyl diphosphate"}
{"X":46260,"RHEA_ID":44659,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a monoacyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine"}
{"X":46261,"RHEA_ID":44660,"compounds":"1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-alkyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine + H(+)"}
{"X":46262,"RHEA_ID":44661,"compounds":"1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + sphing-4-enine => 1-O-alkyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine + H(+)"}
{"X":46263,"RHEA_ID":54646,"compounds":"(S)-1-pyrroline-5-carboxylate + H(+) + H2O => trans-4-hydroxy-L-proline"}
{"X":46264,"RHEA_ID":44663,"compounds":"1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + sphing-4-enine <=> 1-O-alkyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine + H(+)"}
{"X":46265,"RHEA_ID":44664,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + a monoacyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":46266,"RHEA_ID":44665,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O => a fatty acid + a monoacyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":46267,"RHEA_ID":47960,"DIRECTION":"UN","MASTER_ID":47960,"ec":"3.9.1.3","compounds":"H2O + N(tele)-phospho-L-histidyl-[protein] = L-histidyl-[protein] + phosphate"}
{"X":46268,"RHEA_ID":44667,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O <=> a fatty acid + a monoacyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":46269,"RHEA_ID":44668,"DIRECTION":"UN","MASTER_ID":44668,"ec":"2.7.8.47","compounds":"4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol = 4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+)"}
{"X":46270,"RHEA_ID":44669,"DIRECTION":"LR","MASTER_ID":44668,"metacyc":"RXN-18016","compounds":"4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol => 4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+)"}
{"X":46271,"RHEA_ID":57997,"DIRECTION":"LR","MASTER_ID":57996,"metacyc":"RXN-19698","compounds":"(20S)-protopanaxadiol + UDP-alpha-D-glucose => (20S)-ginsenoside Rh2 + H(+) + UDP"}
{"X":46272,"RHEA_ID":44672,"compounds":"1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O = a 1-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)"}
{"X":46273,"RHEA_ID":44673,"compounds":"1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O => a 1-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)"}
{"X":46274,"RHEA_ID":47966,"compounds":"L-histidyl-[protein] + phosphate => H2O + N(pros)-phospho-L-histidyl-[protein]"}
{"X":46275,"RHEA_ID":44675,"compounds":"1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O <=> a 1-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)"}
{"X":46276,"RHEA_ID":44676,"compounds":"a triacyl-sn-glycerol + all-trans-retinol = a diacylglycerol + an all-trans-retinyl ester"}
{"X":46277,"RHEA_ID":44677,"compounds":"a triacyl-sn-glycerol + all-trans-retinol => a diacylglycerol + an all-trans-retinyl ester"}
{"X":46278,"RHEA_ID":54662,"compounds":"an aromatic aldehyde + hydrogen cyanide => an aromatic (S)-hydroxynitrile"}
{"X":46279,"RHEA_ID":44679,"compounds":"a triacyl-sn-glycerol + all-trans-retinol <=> a diacylglycerol + an all-trans-retinyl ester"}
{"X":46280,"RHEA_ID":54664,"DIRECTION":"UN","MASTER_ID":54664,"ec":"5.4.99.65","compounds":"(3S,22S)-2,3:22,23-diepoxy-2,3,22,23-tetrahydrosqualene = pre-alpha-onocerin"}
{"X":46281,"RHEA_ID":44681,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ADP + H(+)"}
{"X":46282,"RHEA_ID":47974,"compounds":"dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H2O => dTDP-4-dehydro-6-deoxy-alpha-D-glucose"}
{"X":46283,"RHEA_ID":44683,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ADP + H(+)"}
{"X":46284,"RHEA_ID":44684,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine"}
{"X":46285,"RHEA_ID":44685,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine"}
{"X":46286,"RHEA_ID":54670,"compounds":"alpha-onocerin => pre-alpha-onocerin"}
{"X":46287,"RHEA_ID":44687,"compounds":"1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine"}
{"X":46288,"RHEA_ID":54672,"DIRECTION":"UN","MASTER_ID":54672,"ec":"3.1.7.12","compounds":"(+)-kolavenyl diphosphate + H2O = (+)-kolavelool + diphosphate"}
{"X":46289,"RHEA_ID":44689,"compounds":"a 2-acylglycerol + H2O => a fatty acid + glycerol + H(+)"}
{"X":46290,"RHEA_ID":44690,"compounds":"a fatty acid + glycerol + H(+) => a 2-acylglycerol + H2O"}
{"X":46291,"RHEA_ID":44691,"compounds":"a 2-acylglycerol + H2O <=> a fatty acid + glycerol + H(+)"}
{"X":46292,"RHEA_ID":54676,"DIRECTION":"UN","MASTER_ID":54676,"ec":"5.5.1.29","compounds":"all-trans-geranylgeranyl diphosphate = (+)-kolavenyl diphosphate"}
{"X":46293,"RHEA_ID":44693,"compounds":"an acyl-CoA + hexadecasphinganine => CoA + H(+) + N-acylhexadecasphinganine"}
{"X":46294,"RHEA_ID":54678,"compounds":"(+)-kolavenyl diphosphate => all-trans-geranylgeranyl diphosphate"}
{"X":46295,"RHEA_ID":44695,"compounds":"an acyl-CoA + hexadecasphinganine <=> CoA + H(+) + N-acylhexadecasphinganine"}
{"X":46296,"RHEA_ID":47988,"DIRECTION":"UN","MASTER_ID":47988,"ec":"1.1.1.389","compounds":"2-dehydro-3-deoxy-L-galactonate + NAD(+) = 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH"}
{"X":46297,"RHEA_ID":44697,"compounds":"a 2-acyl-sn-glycero-3-phosphocholine + H2O => a fatty acid + H(+) + sn-glycerol 3-phosphocholine"}
{"X":46298,"RHEA_ID":54686,"compounds":"(-)-kolavenyl diphosphate => all-trans-geranylgeranyl diphosphate"}
{"X":46299,"RHEA_ID":44699,"compounds":"a 2-acyl-sn-glycero-3-phosphocholine + H2O <=> a fatty acid + H(+) + sn-glycerol 3-phosphocholine"}
{"X":46300,"RHEA_ID":54688,"DIRECTION":"UN","MASTER_ID":54688,"ec":"4.4.1.4","compounds":"alliin = 2-aminoprop-2-enoate + allylsulfenate"}
{"X":46301,"RHEA_ID":44701,"compounds":"a 2,3-saturated acyl-CoA + FAD + H(+) => a (2E)-enoyl-CoA + FADH2"}
{"X":46302,"RHEA_ID":54690,"compounds":"2-aminoprop-2-enoate + allylsulfenate => alliin"}
{"X":46303,"RHEA_ID":44703,"compounds":"a 2,3-saturated acyl-CoA + FAD + H(+) <=> a (2E)-enoyl-CoA + FADH2"}
{"X":46304,"RHEA_ID":54692,"DIRECTION":"UN","MASTER_ID":54692,"ec":"5.5.1.30","compounds":"all-trans-geranylgeranyl diphosphate = (13E)-labda-7,13-dien-15-yl diphosphate"}
{"X":46305,"RHEA_ID":44705,"DIRECTION":"LR","MASTER_ID":44704,"metacyc":"ACYLCOADEHYDROG-RXN","compounds":"a 2,3-saturated acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":46306,"RHEA_ID":54694,"compounds":"(13E)-labda-7,13-dien-15-yl diphosphate => all-trans-geranylgeranyl diphosphate"}
{"X":46307,"RHEA_ID":44707,"compounds":"a 2,3-saturated acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":46308,"RHEA_ID":48000,"DIRECTION":"UN","MASTER_ID":48000,"ec":"1.6.3.5","compounds":"1,6-dihydro-beta-NADP + H(+) + O2 = H2O2 + NADP(+)"}
{"X":46309,"RHEA_ID":44709,"compounds":"a 1-acyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine"}
{"X":46310,"RHEA_ID":54698,"compounds":"4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + diphosphate => 4-hydroxybenzoate + ATP + holo-[4-hydroxyphenylalkanoate synthase]"}
{"X":46311,"RHEA_ID":44711,"compounds":"a 1-acyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine"}
{"X":46312,"RHEA_ID":54700,"compounds":"4-hydroxybenzoyl-5'-AMP + holo-[4-hydroxyphenylalkanoate synthase] = 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + H(+)"}
{"X":46313,"RHEA_ID":44713,"compounds":"a 1,2-diacylglycerol + H2O => a 1-acylglycerol + a fatty acid + H(+)"}
{"X":46314,"RHEA_ID":48006,"compounds":"3,4-dimethoxybenzaldehyde + glycolaldehyde + guaiacol + H2O => 1-(3,4-dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2"}
{"X":46315,"RHEA_ID":44715,"compounds":"a 1,2-diacylglycerol + H2O <=> a 1-acylglycerol + a fatty acid + H(+)"}
{"X":46316,"RHEA_ID":44716,"DIRECTION":"UN","MASTER_ID":44716,"ec":"1.2.99.10","compounds":"A + all-trans-4,4'-diapolycopen-4-al + H2O = AH2 + all-trans-4,4'-diapolycopen-4-oate + H(+)"}
{"X":46317,"RHEA_ID":44717,"DIRECTION":"LR","MASTER_ID":44716,"metacyc":"RXN-18993","compounds":"A + all-trans-4,4'-diapolycopen-4-al + H2O => AH2 + all-trans-4,4'-diapolycopen-4-oate + H(+)"}
{"X":46318,"RHEA_ID":54706,"compounds":"H(+) + N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine"}
{"X":46319,"RHEA_ID":54707,"compounds":"N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":46320,"RHEA_ID":54708,"compounds":"N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":46321,"RHEA_ID":44721,"compounds":"a 1-acyl-sn-glycero-3-phosphocholine + H2O => a 1-acyl-sn-glycerol + H(+) + phosphocholine"}
{"X":46322,"RHEA_ID":48014,"compounds":"2-hydroxy-5-methylquinone + H(+) + H2O + NADP(+) + nitrite => 4-methyl-5-nitrocatechol + NADPH + O2"}
{"X":46323,"RHEA_ID":44723,"compounds":"a 1-acyl-sn-glycero-3-phosphocholine + H2O <=> a 1-acyl-sn-glycerol + H(+) + phosphocholine"}
{"X":46324,"RHEA_ID":54712,"DIRECTION":"UN","MASTER_ID":54712,"ec":"2.1.1.244","compounds":"N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine"}
{"X":46325,"RHEA_ID":44725,"compounds":"2,3-saturated fatty aldehyde + NADP(+) => (2E)-fatty aldehyde + H(+) + NADPH"}
{"X":46326,"RHEA_ID":44726,"compounds":"(2E)-fatty aldehyde + H(+) + NADPH => 2,3-saturated fatty aldehyde + NADP(+)"}
{"X":46327,"RHEA_ID":44727,"compounds":"2,3-saturated fatty aldehyde + NADP(+) <=> (2E)-fatty aldehyde + H(+) + NADPH"}
{"X":46328,"RHEA_ID":54716,"compounds":"N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":46329,"RHEA_ID":44729,"compounds":"1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+)"}
{"X":46330,"RHEA_ID":44730,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+) => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O"}
{"X":46331,"RHEA_ID":44731,"compounds":"1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+)"}
{"X":46332,"RHEA_ID":54720,"compounds":"N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":46333,"RHEA_ID":44733,"compounds":"2-(9Z,12Z-octadecadienoyl)-glycerol + H2O => (9Z,12Z)-octadecadienoate + glycerol + H(+)"}
{"X":46334,"RHEA_ID":48026,"compounds":"dipropanoylglycerol + H(+) + propanoate => 1,2,3-tripropanoylglycerol + H2O"}
{"X":46335,"RHEA_ID":44735,"compounds":"2-(9Z,12Z-octadecadienoyl)-glycerol + H2O <=> (9Z,12Z)-octadecadienoate + glycerol + H(+)"}
{"X":46336,"RHEA_ID":54724,"DIRECTION":"UN","MASTER_ID":54724,"ec":"2.1.1.244","compounds":"N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine"}
{"X":46337,"RHEA_ID":44737,"compounds":"acetyl-CoA + dihydroxyacetone phosphate => 3-hydroxy-2,4-pentanedione 5-phosphate + CoA"}
{"X":46338,"RHEA_ID":48030,"compounds":"acetate + diacetylglycerol + H(+) => H2O + triacetin"}
{"X":46339,"RHEA_ID":54727,"compounds":"N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine"}
{"X":46340,"RHEA_ID":54728,"DIRECTION":"UN","MASTER_ID":54728,"ec":"2.1.3.15","compounds":"acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]"}
{"X":46341,"RHEA_ID":44741,"DIRECTION":"LR","MASTER_ID":44740,"metacyc":"RXN-9611","compounds":"27-O-demethylrifamycin SV + S-adenosyl-L-methionine => H(+) + rifamycin SV + S-adenosyl-L-homocysteine"}
{"X":46342,"RHEA_ID":44742,"compounds":"H(+) + rifamycin SV + S-adenosyl-L-homocysteine => 27-O-demethylrifamycin SV + S-adenosyl-L-methionine"}
{"X":46343,"RHEA_ID":48035,"compounds":"(2S)-2-methylbutanoyl-CoA + FAD + H(+) <=> (2E)-2-methylbutenoyl-CoA + FADH2"}
{"X":46344,"RHEA_ID":44744,"DIRECTION":"UN","MASTER_ID":44744,"ec":"2.3.1.246","compounds":"4 H(+) + 4 malonyl-CoA = (3,5-dihydroxyphenyl)acetyl-CoA + 4 CO2 + 3 CoA + H2O"}
{"X":46345,"RHEA_ID":44745,"compounds":"4 H(+) + 4 malonyl-CoA => (3,5-dihydroxyphenyl)acetyl-CoA + 4 CO2 + 3 CoA + H2O"}
{"X":46346,"RHEA_ID":54734,"compounds":"H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine"}
{"X":46347,"RHEA_ID":54735,"compounds":"N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":46348,"RHEA_ID":54736,"DIRECTION":"UN","MASTER_ID":54736,"ec":"2.1.1.244","compounds":"N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine"}
{"X":46349,"RHEA_ID":44749,"DIRECTION":"LR","MASTER_ID":44748,"metacyc":"RXN-19750","compounds":"5-amino-1-(beta-D-ribosyl)imidazole + ATP => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+)"}
{"X":46350,"RHEA_ID":54738,"compounds":"2 H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine => N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine"}
{"X":46351,"RHEA_ID":44751,"compounds":"5-amino-1-(beta-D-ribosyl)imidazole + ATP <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+)"}
{"X":46352,"RHEA_ID":44752,"DIRECTION":"UN","MASTER_ID":44752,"ec":"2.1.1.201","compounds":"2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = 6-methoxy-3-methyl-2-all-trans-hexaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine"}
{"X":46353,"RHEA_ID":44753,"DIRECTION":"LR","MASTER_ID":44752,"metacyc":"RXN3O-54","compounds":"2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine => 6-methoxy-3-methyl-2-all-trans-hexaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine"}
{"X":46354,"RHEA_ID":48046,"compounds":"D-galactose + ganglioside GM2 (d18:1(4E)/18:0) => ganglioside GM1 (d18:1(4E)/18:0) + H2O"}
{"X":46355,"RHEA_ID":54743,"compounds":"9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":46356,"RHEA_ID":54744,"compounds":"9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":46357,"RHEA_ID":44757,"DIRECTION":"LR","MASTER_ID":44756,"metacyc":"RXN-9227","compounds":"2-methoxy-6-all-trans-heptaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine => 6-methoxy-3-methyl-2-all-trans-heptaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine"}
{"X":46358,"RHEA_ID":44758,"compounds":"6-methoxy-3-methyl-2-all-trans-heptaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine => 2-methoxy-6-all-trans-heptaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine"}
{"X":46359,"RHEA_ID":44759,"compounds":"2-methoxy-6-all-trans-heptaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine <=> 6-methoxy-3-methyl-2-all-trans-heptaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine"}
{"X":46360,"RHEA_ID":54748,"DIRECTION":"UN","MASTER_ID":54748,"ec":"6.2.1.52","compounds":"ATP + CoA + firefly L-luciferin = AMP + diphosphate + L-firefly luciferyl-CoA"}
{"X":46361,"RHEA_ID":44761,"DIRECTION":"LR","MASTER_ID":44760,"metacyc":"RXN-9242","compounds":"2-methoxy-6-all-trans-nonaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine => 6-methoxy-3-methyl-2-all-trans-nonaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine"}
{"X":46362,"RHEA_ID":44762,"compounds":"6-methoxy-3-methyl-2-all-trans-nonaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine => 2-methoxy-6-all-trans-nonaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine"}
{"X":46363,"RHEA_ID":44763,"compounds":"2-methoxy-6-all-trans-nonaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine <=> 6-methoxy-3-methyl-2-all-trans-nonaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine"}
{"X":46364,"RHEA_ID":54752,"DIRECTION":"UN","MASTER_ID":54752,"ec":"1.5.98.3","compounds":"methanophenazine + reduced coenzyme F420-(gamma-Glu)(n) = dihydromethanophenazine + H(+) + oxidized coenzyme F420-(gamma-Glu)(n)"}
{"X":46365,"RHEA_ID":44765,"DIRECTION":"LR","MASTER_ID":44764,"metacyc":"RXN-9235","reactome":"R-HSA-2162188.3","compounds":"2-methoxy-6-all-trans-decaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine => 6-methoxy-3-methyl-2-all-trans-decaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine"}
{"X":46366,"RHEA_ID":44766,"compounds":"6-methoxy-3-methyl-2-all-trans-decaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine => 2-methoxy-6-all-trans-decaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine"}
{"X":46367,"RHEA_ID":44767,"compounds":"2-methoxy-6-all-trans-decaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine <=> 6-methoxy-3-methyl-2-all-trans-decaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine"}
{"X":46368,"RHEA_ID":54756,"DIRECTION":"UN","MASTER_ID":54756,"ec":"2.5.1.143","compounds":"deamido-NAD(+) + hydrogencarbonate = AMP + 2 H(+) + pyridinium-3,5-dicarboxylate mononucleotide"}
{"X":46369,"RHEA_ID":44769,"DIRECTION":"LR","MASTER_ID":44768,"metacyc":"RXN3O-73","compounds":"3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) => 2-methoxy-6-(all-trans-hexaprenyl)phenol + CO2"}
{"X":46370,"RHEA_ID":48062,"compounds":"a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + D-galactose => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H2O"}
{"X":46371,"RHEA_ID":58097,"compounds":"1-tetracosanoylglycerol + H2O => glycerol + H(+) + tetracosanoate"}
{"X":46372,"RHEA_ID":54760,"compounds":"ATP + H(+) + pyridinium-3,5-dicarboxylate mononucleotide = 5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + diphosphate"}
{"X":46373,"RHEA_ID":44773,"DIRECTION":"LR","MASTER_ID":44772,"metacyc":"RXN3O-12","compounds":"2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + NADPH + O2 => 2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + H2O + NADP(+)"}
{"X":46374,"RHEA_ID":48066,"compounds":"ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate => ganglioside GD1b (d18:1(4E)) + H2O"}
{"X":46375,"RHEA_ID":44775,"compounds":"2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + NADPH + O2 <=> 2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + H2O + NADP(+)"}
{"X":46376,"RHEA_ID":54764,"compounds":"5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine = [LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+)"}
{"X":46377,"RHEA_ID":44777,"DIRECTION":"LR","MASTER_ID":44776,"metacyc":"RXN-9220","compounds":"2-demethylmenaquinol-6 + S-adenosyl-L-methionine => H(+) + menaquinol-6 + S-adenosyl-L-homocysteine"}
{"X":46378,"RHEA_ID":44778,"compounds":"H(+) + menaquinol-6 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-6 + S-adenosyl-L-methionine"}
{"X":46379,"RHEA_ID":44779,"compounds":"2-demethylmenaquinol-6 + S-adenosyl-L-methionine <=> H(+) + menaquinol-6 + S-adenosyl-L-homocysteine"}
{"X":46380,"RHEA_ID":58106,"compounds":"(14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate => (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O"}
{"X":46381,"RHEA_ID":44781,"DIRECTION":"LR","MASTER_ID":44780,"metacyc":"RXN-9205","compounds":"2-demethylmenaquinol-9 + S-adenosyl-L-methionine => H(+) + menaquinol-9 + S-adenosyl-L-homocysteine"}
{"X":46382,"RHEA_ID":54770,"compounds":"[LarE protein]-dehydroalanine + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide => [LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine"}
{"X":46383,"RHEA_ID":44783,"compounds":"2-demethylmenaquinol-9 + S-adenosyl-L-methionine <=> H(+) + menaquinol-9 + S-adenosyl-L-homocysteine"}
{"X":46384,"RHEA_ID":58110,"compounds":"acetate + L-lysyl-[protein] => H2O + N(6)-acetyl-L-lysyl-[protein]"}
{"X":46385,"RHEA_ID":44785,"DIRECTION":"LR","MASTER_ID":44784,"metacyc":"RXN-9361","compounds":"2-demethylmenaquinol-10 + S-adenosyl-L-methionine => H(+) + menaquinol-10 + S-adenosyl-L-homocysteine"}
{"X":46386,"RHEA_ID":44786,"compounds":"H(+) + menaquinol-10 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-10 + S-adenosyl-L-methionine"}
{"X":46387,"RHEA_ID":44787,"compounds":"2-demethylmenaquinol-10 + S-adenosyl-L-methionine <=> H(+) + menaquinol-10 + S-adenosyl-L-homocysteine"}
{"X":46388,"RHEA_ID":54776,"compounds":"1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine = [LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+)"}
{"X":46389,"RHEA_ID":44789,"DIRECTION":"LR","MASTER_ID":44788,"metacyc":"RXN-9362","compounds":"2-demethylmenaquinol-11 + S-adenosyl-L-methionine => H(+) + menaquinol-11 + S-adenosyl-L-homocysteine"}
{"X":46390,"RHEA_ID":44790,"compounds":"H(+) + menaquinol-11 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-11 + S-adenosyl-L-methionine"}
{"X":46391,"RHEA_ID":54779,"compounds":"1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine <=> [LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+)"}
{"X":46392,"RHEA_ID":54780,"compounds":"[LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine = [LarE protein]-dehydroalanine + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide"}
{"X":46393,"RHEA_ID":44793,"DIRECTION":"LR","MASTER_ID":44792,"metacyc":"RXN-9363","compounds":"2-demethylmenaquinol-12 + S-adenosyl-L-methionine => H(+) + menaquinol-12 + S-adenosyl-L-homocysteine"}
{"X":46394,"RHEA_ID":44794,"compounds":"H(+) + menaquinol-12 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-12 + S-adenosyl-L-methionine"}
{"X":46395,"RHEA_ID":44795,"compounds":"2-demethylmenaquinol-12 + S-adenosyl-L-methionine <=> H(+) + menaquinol-12 + S-adenosyl-L-homocysteine"}
{"X":46396,"RHEA_ID":54784,"DIRECTION":"UN","MASTER_ID":54784,"ec":"4.99.1.12","compounds":"Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide = Ni(2+) + pyridinium-3,5-bisthiocarboxylate mononucleotide"}
{"X":46397,"RHEA_ID":44797,"DIRECTION":"LR","MASTER_ID":44796,"metacyc":"RXN-9366","compounds":"2-demethylmenaquinol-13 + S-adenosyl-L-methionine => H(+) + menaquinol-13 + S-adenosyl-L-homocysteine"}
{"X":46398,"RHEA_ID":44798,"compounds":"H(+) + menaquinol-13 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-13 + S-adenosyl-L-methionine"}
{"X":46399,"RHEA_ID":61825,"compounds":"pregnenolone + UDP-alpha-D-glucose => H(+) + pregnenolone 3-beta-D-glucoside + UDP"}
{"X":46400,"RHEA_ID":44800,"DIRECTION":"UN","MASTER_ID":44800,"ec":"2.5.1.74","compounds":"1,4-dihydroxy-2-naphthoate + all-trans-hexaprenyl diphosphate + H(+) = 2-demethylmenaquinol-6 + CO2 + diphosphate"}
{"X":46401,"RHEA_ID":44801,"DIRECTION":"LR","MASTER_ID":44800,"metacyc":"RXN-9217","compounds":"1,4-dihydroxy-2-naphthoate + all-trans-hexaprenyl diphosphate + H(+) => 2-demethylmenaquinol-6 + CO2 + diphosphate"}
{"X":46402,"RHEA_ID":44802,"compounds":"2-demethylmenaquinol-6 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-hexaprenyl diphosphate + H(+)"}
{"X":46403,"RHEA_ID":54791,"compounds":"[LarE protein]-L-cysteine + ATP + pyridinium-3,5-dicarboxylate mononucleotide <=> [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide"}
{"X":46404,"RHEA_ID":54792,"compounds":"7-methyl-GTP + [nsP1 protein]-L-histidine = [nsP1 protein]-N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidine + diphosphate"}
{"X":46405,"RHEA_ID":44805,"DIRECTION":"LR","MASTER_ID":44804,"metacyc":"RXN-9204","compounds":"1,4-dihydroxy-2-naphthoate + all-trans-nonaprenyl diphosphate + H(+) => 2-demethylmenaquinol-9 + CO2 + diphosphate"}
{"X":46406,"RHEA_ID":44806,"compounds":"2-demethylmenaquinol-9 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-nonaprenyl diphosphate + H(+)"}
{"X":46407,"RHEA_ID":54795,"compounds":"7-methyl-GTP + [nsP1 protein]-L-histidine <=> [nsP1 protein]-N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidine + diphosphate"}
{"X":46408,"RHEA_ID":54796,"DIRECTION":"UN","MASTER_ID":54796,"ec":"1.1.1.412","compounds":"a (2R,3S)-2-alkyl-3-hydroxyalkanoate + NADP(+) = an (R)-2-alkyl-3-oxoalkanoate + H(+) + NADPH"}
{"X":46409,"RHEA_ID":44809,"DIRECTION":"LR","MASTER_ID":44808,"metacyc":"RXN-9358","compounds":"1,4-dihydroxy-2-naphthoate + all-trans-decaprenyl diphosphate + H(+) => 2-demethylmenaquinol-10 + CO2 + diphosphate"}
{"X":46410,"RHEA_ID":44810,"compounds":"2-demethylmenaquinol-10 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-decaprenyl diphosphate + H(+)"}
{"X":46411,"RHEA_ID":44812,"DIRECTION":"UN","MASTER_ID":44812,"ec":"2.5.1.74","compounds":"1,4-dihydroxy-2-naphthoate + all-trans-undecaprenyl diphosphate + H(+) = 2-demethylmenaquinol-11 + CO2 + diphosphate"}
{"X":46412,"RHEA_ID":44813,"DIRECTION":"LR","MASTER_ID":44812,"metacyc":"RXN-9359","compounds":"1,4-dihydroxy-2-naphthoate + all-trans-undecaprenyl diphosphate + H(+) => 2-demethylmenaquinol-11 + CO2 + diphosphate"}
{"X":46413,"RHEA_ID":44814,"compounds":"2-demethylmenaquinol-11 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-undecaprenyl diphosphate + H(+)"}
{"X":46414,"RHEA_ID":44815,"compounds":"1,4-dihydroxy-2-naphthoate + all-trans-undecaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-11 + CO2 + diphosphate"}
{"X":46415,"RHEA_ID":44816,"DIRECTION":"UN","MASTER_ID":44816,"ec":"2.5.1.74","compounds":"1,4-dihydroxy-2-naphthoate + all-trans-dodecaprenyl diphosphate + H(+) = 2-demethylmenaquinol-12 + CO2 + diphosphate"}
{"X":46416,"RHEA_ID":54805,"compounds":"2 4-sulfanylbutanoate + NAD(+) => 4,4'-disulfanyldibutanoate + H(+) + NADH"}
{"X":46417,"RHEA_ID":44818,"compounds":"2-demethylmenaquinol-12 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-dodecaprenyl diphosphate + H(+)"}
{"X":46418,"RHEA_ID":44819,"compounds":"1,4-dihydroxy-2-naphthoate + all-trans-dodecaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-12 + CO2 + diphosphate"}
{"X":46419,"RHEA_ID":44820,"DIRECTION":"UN","MASTER_ID":44820,"ec":"2.5.1.74","compounds":"1,4-dihydroxy-2-naphthoate + all-trans-tridecaprenyl diphosphate + H(+) = 2-demethylmenaquinol-13 + CO2 + diphosphate"}
{"X":46420,"RHEA_ID":54809,"DIRECTION":"LR","MASTER_ID":54808,"metacyc":"RXN-12421","compounds":"H(+) + L-isoleucine-(+)-7-isojasmonate + NADPH + O2 => H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate + NADP(+)"}
{"X":46421,"RHEA_ID":44822,"compounds":"2-demethylmenaquinol-13 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-tridecaprenyl diphosphate + H(+)"}
{"X":46422,"RHEA_ID":44823,"compounds":"1,4-dihydroxy-2-naphthoate + all-trans-tridecaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-13 + CO2 + diphosphate"}
{"X":46423,"RHEA_ID":54812,"compounds":"(+)-7-isojasmonate + ATP + L-isoleucine = AMP + diphosphate + H(+) + L-isoleucine-(+)-7-isojasmonate"}
{"X":46424,"RHEA_ID":54813,"compounds":"(+)-7-isojasmonate + ATP + L-isoleucine => AMP + diphosphate + H(+) + L-isoleucine-(+)-7-isojasmonate"}
{"X":46425,"RHEA_ID":44826,"compounds":"a 1,2-diacylglycerol + a monoacyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol"}
{"X":46426,"RHEA_ID":44827,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol <=> a 1,2-diacylglycerol + a monoacyl-sn-glycero-3-phosphocholine"}
{"X":46427,"RHEA_ID":54816,"DIRECTION":"UN","MASTER_ID":54816,"ec":"2.3.2.13","compounds":"L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+)"}
{"X":46428,"RHEA_ID":54817,"DIRECTION":"LR","MASTER_ID":54816,"metacyc":"2.3.2.13-RXN","compounds":"L-glutaminyl-[protein] + L-lysyl-[protein] => [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+)"}
{"X":46429,"RHEA_ID":44830,"compounds":"CoA + O-decanoyl-(R)-carnitine => (R)-carnitine + decanoyl-CoA"}
{"X":46430,"RHEA_ID":44831,"DIRECTION":"BI","MASTER_ID":44828,"metacyc":"RXN-18371","compounds":"(R)-carnitine + decanoyl-CoA <=> CoA + O-decanoyl-(R)-carnitine"}
{"X":46431,"RHEA_ID":44832,"compounds":"(R)-carnitine + tetradecanoyl-CoA = CoA + O-tetradecanoyl-(R)-carnitine"}
{"X":46432,"RHEA_ID":54821,"DIRECTION":"LR","MASTER_ID":54820,"metacyc":"2.4.1.150-RXN","compounds":"a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + UDP-N-acetyl-alpha-D-glucosamine => a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP"}
{"X":46433,"RHEA_ID":44834,"compounds":"CoA + O-tetradecanoyl-(R)-carnitine => (R)-carnitine + tetradecanoyl-CoA"}
{"X":46434,"RHEA_ID":44835,"DIRECTION":"BI","MASTER_ID":44832,"metacyc":"RXN-18370","compounds":"(R)-carnitine + tetradecanoyl-CoA <=> CoA + O-tetradecanoyl-(R)-carnitine"}
{"X":46435,"RHEA_ID":54824,"DIRECTION":"UN","MASTER_ID":54824,"ec":"3.2.1.130","compounds":"H2O + N-{alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-asparaginyl-[protein] = alpha-D-glucosyl-(1->3)-D-mannopyranose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)"}
{"X":46436,"RHEA_ID":54825,"DIRECTION":"LR","MASTER_ID":54824,"metacyc":"3.2.1.130-RXN","compounds":"H2O + N-{alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-asparaginyl-[protein] => alpha-D-glucosyl-(1->3)-D-mannopyranose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)"}
{"X":46437,"RHEA_ID":44838,"compounds":"globoside NOR2 (d18:1(4E)) + H(+) + UDP => globoside NORint (d18:1(4E)) + UDP-alpha-D-galactose"}
{"X":46438,"RHEA_ID":44839,"compounds":"globoside NORint (d18:1(4E)) + UDP-alpha-D-galactose <=> globoside NOR2 (d18:1(4E)) + H(+) + UDP"}
{"X":46439,"RHEA_ID":54828,"DIRECTION":"UN","MASTER_ID":54828,"ec":"1.14.13.238","compounds":"dimethylamine + H(+) + NADPH + O2 = formaldehyde + H2O + methylamine + NADP(+)"}
{"X":46440,"RHEA_ID":44841,"compounds":"(R)-carnitine + octadecanoyl-CoA => CoA + O-octadecanoyl-(R)-carnitine"}
{"X":46441,"RHEA_ID":44842,"compounds":"CoA + O-octadecanoyl-(R)-carnitine => (R)-carnitine + octadecanoyl-CoA"}
{"X":46442,"RHEA_ID":44843,"DIRECTION":"BI","MASTER_ID":44840,"metacyc":"RXN-18372","compounds":"(R)-carnitine + octadecanoyl-CoA <=> CoA + O-octadecanoyl-(R)-carnitine"}
{"X":46443,"RHEA_ID":54832,"DIRECTION":"UN","MASTER_ID":54832,"ec":"1.14.14.48","compounds":"a jasmonyl-L-amino acid + O2 + reduced [NADPH--hemoprotein reductase] = a 12-hydroxyjasmonyl-L-alpha-amino acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":46444,"RHEA_ID":44845,"compounds":"(R)-carnitine + eicosanoyl-CoA => CoA + O-eicosanoyl-(R)-carnitine"}
{"X":46445,"RHEA_ID":44846,"compounds":"CoA + O-eicosanoyl-(R)-carnitine => (R)-carnitine + eicosanoyl-CoA"}
{"X":46446,"RHEA_ID":44847,"compounds":"(R)-carnitine + eicosanoyl-CoA <=> CoA + O-eicosanoyl-(R)-carnitine"}
{"X":46447,"RHEA_ID":54836,"compounds":"H(+) + heptan-2-one + NADPH + O2 = H2O + NADP(+) + pentyl acetate"}
{"X":46448,"RHEA_ID":54837,"compounds":"H(+) + heptan-2-one + NADPH + O2 => H2O + NADP(+) + pentyl acetate"}
{"X":46449,"RHEA_ID":44850,"compounds":"CoA + O-(9Z)-tetradecenoyl-(R)-carnitine => (9Z)-tetradecenoyl-CoA + (R)-carnitine"}
{"X":46450,"RHEA_ID":44851,"compounds":"(9Z)-tetradecenoyl-CoA + (R)-carnitine <=> CoA + O-(9Z)-tetradecenoyl-(R)-carnitine"}
{"X":46451,"RHEA_ID":54840,"compounds":"H(+) + NADPH + O2 + octan-3-one = H2O + NADP(+) + pentyl propanoate"}
{"X":46452,"RHEA_ID":54841,"compounds":"H(+) + NADPH + O2 + octan-3-one => H2O + NADP(+) + pentyl propanoate"}
{"X":46453,"RHEA_ID":44854,"compounds":"CoA + O-(5Z)-tetradecenoyl-(R)-carnitine => (5Z)-tetradecenoyl-CoA + (R)-carnitine"}
{"X":46454,"RHEA_ID":44855,"compounds":"(5Z)-tetradecenoyl-CoA + (R)-carnitine <=> CoA + O-(5Z)-tetradecenoyl-(R)-carnitine"}
{"X":46455,"RHEA_ID":54844,"compounds":"H(+) + hexan-3-one + NADPH + O2 = ethyl butanoate + H2O + NADP(+)"}
{"X":46456,"RHEA_ID":54845,"compounds":"H(+) + hexan-3-one + NADPH + O2 => ethyl butanoate + H2O + NADP(+)"}
{"X":46457,"RHEA_ID":44858,"compounds":"CoA + O-(9Z)-octadecenoyl-(R)-carnitine => (9Z)-octadecenoyl-CoA + (R)-carnitine"}
{"X":46458,"RHEA_ID":44859,"compounds":"(9Z)-octadecenoyl-CoA + (R)-carnitine <=> CoA + O-(9Z)-octadecenoyl-(R)-carnitine"}
{"X":46459,"RHEA_ID":44860,"compounds":"(R)-carnitine + 4,8-dimethylnonanoyl-CoA = CoA + O-4,8-dimethylnonanoyl-(R)-carnitine"}
{"X":46460,"RHEA_ID":54849,"compounds":"H(+) + hexan-3-one + NADPH + O2 => H2O + NADP(+) + propyl propanoate"}
{"X":46461,"RHEA_ID":44862,"compounds":"CoA + O-4,8-dimethylnonanoyl-(R)-carnitine => (R)-carnitine + 4,8-dimethylnonanoyl-CoA"}
{"X":46462,"RHEA_ID":44863,"compounds":"(R)-carnitine + 4,8-dimethylnonanoyl-CoA <=> CoA + O-4,8-dimethylnonanoyl-(R)-carnitine"}
{"X":46463,"RHEA_ID":44864,"compounds":"a triacyl-sn-glycerol + H2O = a 1,2-diacylglycerol + a fatty acid + H(+)"}
{"X":46464,"RHEA_ID":54853,"compounds":"H(+) + heptan-4-one + NADPH + O2 => H2O + NADP(+) + propyl butanoate"}
{"X":46465,"RHEA_ID":44866,"compounds":"a 1,2-diacylglycerol + a fatty acid + H(+) => a triacyl-sn-glycerol + H2O"}
{"X":46466,"RHEA_ID":44867,"compounds":"a triacyl-sn-glycerol + H2O <=> a 1,2-diacylglycerol + a fatty acid + H(+)"}
{"X":46467,"RHEA_ID":54856,"compounds":"H(+) + NADPH + O2 + octan-3-one = ethyl hexanoate + H2O + NADP(+)"}
{"X":46468,"RHEA_ID":44869,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + ethanol => 1,2-diacyl-sn-glycero-3-phosphoethanol + choline"}
{"X":46469,"RHEA_ID":44870,"compounds":"1,2-diacyl-sn-glycero-3-phosphoethanol + choline => a 1,2-diacyl-sn-glycero-3-phosphocholine + ethanol"}
{"X":46470,"RHEA_ID":44871,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + ethanol <=> 1,2-diacyl-sn-glycero-3-phosphoethanol + choline"}
{"X":46471,"RHEA_ID":54860,"compounds":"geranial + H(+) + NADPH + O2 = (1E)-2,6-dimethylhepta-1,5-dien-1-yl formate + H2O + NADP(+)"}
{"X":46472,"RHEA_ID":54861,"compounds":"geranial + H(+) + NADPH + O2 => (1E)-2,6-dimethylhepta-1,5-dien-1-yl formate + H2O + NADP(+)"}
{"X":46473,"RHEA_ID":44874,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":46474,"RHEA_ID":44875,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)"}
{"X":46475,"RHEA_ID":44876,"compounds":"a 1,3-diacylglycerol + H2O = 3-acyl-sn-glycerol + a fatty acid + H(+)"}
{"X":46476,"RHEA_ID":54865,"compounds":"H(+) + NADPH + O2 + sulcatone => 4-methylpent-3-en-1-yl acetate + H2O + NADP(+)"}
{"X":46477,"RHEA_ID":44878,"compounds":"3-acyl-sn-glycerol + a fatty acid + H(+) => a 1,3-diacylglycerol + H2O"}
{"X":46478,"RHEA_ID":44879,"compounds":"a 1,3-diacylglycerol + H2O <=> 3-acyl-sn-glycerol + a fatty acid + H(+)"}
{"X":46479,"RHEA_ID":44880,"DIRECTION":"UN","MASTER_ID":44880,"ec":"2.7.11.30","compounds":"[receptor-protein]-L-threonine + ATP = [receptor-protein]-O-phospho-L-threonine + ADP + H(+)"}
{"X":46480,"RHEA_ID":54869,"compounds":"(2E)-butenoyl-[ACP] + H(+) + NADH => butanoyl-[ACP] + NAD(+)"}
{"X":46481,"RHEA_ID":44882,"compounds":"[receptor-protein]-O-phospho-L-threonine + ADP + H(+) => [receptor-protein]-L-threonine + ATP"}
{"X":46482,"RHEA_ID":44883,"compounds":"[receptor-protein]-L-threonine + ATP <=> [receptor-protein]-O-phospho-L-threonine + ADP + H(+)"}
{"X":46483,"RHEA_ID":54872,"compounds":"(1S,4R)-menthone + H(+) + NADPH + O2 = (4S,7R)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)"}
{"X":46484,"RHEA_ID":44889,"compounds":"1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O => 1-O-alkyl-sn-glycero-3-phosphate + a fatty acid + H(+)"}
{"X":46485,"RHEA_ID":44890,"compounds":"1-O-alkyl-sn-glycero-3-phosphate + a fatty acid + H(+) => 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O"}
{"X":46486,"RHEA_ID":44891,"compounds":"1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O <=> 1-O-alkyl-sn-glycero-3-phosphate + a fatty acid + H(+)"}
{"X":46487,"RHEA_ID":54876,"compounds":"(4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one = (3S)-3-isopropenyl-6-oxoheptanoate + H(+)"}
{"X":46488,"RHEA_ID":54877,"DIRECTION":"LR","MASTER_ID":54876,"metacyc":"RXN-9418","compounds":"(4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one => (3S)-3-isopropenyl-6-oxoheptanoate + H(+)"}
{"X":46489,"RHEA_ID":44894,"compounds":"an N-(2-hydroxyacyl)-beta-D-galactosyl-sphinganine + H(+) + UDP => an N-(2-hydroxyacyl)-sphinganine + UDP-alpha-D-galactose"}
{"X":46490,"RHEA_ID":44895,"compounds":"an N-(2-hydroxyacyl)-sphinganine + UDP-alpha-D-galactose <=> an N-(2-hydroxyacyl)-beta-D-galactosyl-sphinganine + H(+) + UDP"}
{"X":46491,"RHEA_ID":54880,"compounds":"(4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one = (3R)-3-isopropenyl-6-oxoheptanoate + H(+)"}
{"X":46492,"RHEA_ID":54881,"DIRECTION":"LR","MASTER_ID":54880,"metacyc":"RXN-9417","compounds":"(4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one => (3R)-3-isopropenyl-6-oxoheptanoate + H(+)"}
{"X":46493,"RHEA_ID":44898,"compounds":"H(+) + N-(2-hydroxyacyl)-beta-D-galactosyl-sphing-4-enine + UDP => a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose"}
{"X":46494,"RHEA_ID":44899,"compounds":"a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose <=> H(+) + N-(2-hydroxyacyl)-beta-D-galactosyl-sphing-4-enine + UDP"}
{"X":46495,"RHEA_ID":54884,"DIRECTION":"UN","MASTER_ID":54884,"ec":"2.4.2.31","compounds":"L-arginyl-[protein] + NADP(+) = H(+) + N(omega)-(2'-phospho-ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide"}
{"X":46496,"RHEA_ID":54885,"compounds":"L-arginyl-[protein] + NADP(+) => H(+) + N(omega)-(2'-phospho-ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide"}
{"X":46497,"RHEA_ID":44902,"compounds":"D-galactonate + H(+) => D-galactono-1,4-lactone + H2O"}
{"X":46498,"RHEA_ID":54887,"compounds":"L-arginyl-[protein] + NADP(+) <=> H(+) + N(omega)-(2'-phospho-ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide"}
{"X":46499,"RHEA_ID":54888,"compounds":"ATP + CoA + OPC-8 = AMP + diphosphate + OPC-8-CoA"}
{"X":46500,"RHEA_ID":54889,"compounds":"ATP + CoA + OPC-8 => AMP + diphosphate + OPC-8-CoA"}
{"X":46501,"RHEA_ID":44905,"DIRECTION":"LR","MASTER_ID":44904,"ecocyc":"RXN-15312","metacyc":"RXN-15312","reactome":"R-HSA-71825.3","compounds":"alpha-D-glucose 6-phosphate + H2O => alpha-D-glucose + phosphate"}
{"X":46502,"RHEA_ID":44905,"DIRECTION":"LR","MASTER_ID":44904,"ecocyc":"RXN-15312","metacyc":"RXN-15312","reactome":"R-HSA-3262512.3","compounds":"alpha-D-glucose 6-phosphate + H2O => alpha-D-glucose + phosphate"}
{"X":46503,"RHEA_ID":54892,"DIRECTION":"UN","MASTER_ID":54892,"ec":"4.4.1.37","compounds":"[LarE protein]-L-cysteine + ATP + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide = [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide"}
{"X":46504,"RHEA_ID":48209,"compounds":"H(+) + nonanoyl-CoA + oxidized [electron-transfer flavoprotein] => (2E)-nonenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":46505,"RHEA_ID":54894,"compounds":"[LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide => [LarE protein]-L-cysteine + ATP + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide"}
{"X":46506,"RHEA_ID":44912,"compounds":"(2E,4E)-hexadienoyl-CoA + H(+) + NADPH = (3E)-hexenoyl-CoA + NADP(+)"}
{"X":46507,"RHEA_ID":54896,"compounds":"(10Z,15Z)-12-oxophytodienoate + ATP + CoA = (10Z,15Z)-12-oxophytodienoyl-CoA + AMP + diphosphate"}
{"X":46508,"RHEA_ID":54897,"compounds":"(10Z,15Z)-12-oxophytodienoate + ATP + CoA => (10Z,15Z)-12-oxophytodienoyl-CoA + AMP + diphosphate"}
{"X":46509,"RHEA_ID":44915,"compounds":"(2E,4E)-hexadienoyl-CoA + H(+) + NADPH <=> (3E)-hexenoyl-CoA + NADP(+)"}
{"X":46510,"RHEA_ID":44916,"compounds":"(2E,4E)-decadienoyl-CoA + H(+) + NADPH = (3E)-decenoyl-CoA + NADP(+)"}
{"X":46511,"RHEA_ID":54900,"compounds":"(2E)-hexadecenoyl-[ACP] + H(+) + NADH = hexadecanoyl-[ACP] + NAD(+)"}
{"X":46512,"RHEA_ID":44918,"compounds":"(3E)-decenoyl-CoA + NADP(+) => (2E,4E)-decadienoyl-CoA + H(+) + NADPH"}
{"X":46513,"RHEA_ID":44919,"compounds":"(2E,4E)-decadienoyl-CoA + H(+) + NADPH <=> (3E)-decenoyl-CoA + NADP(+)"}
{"X":46514,"RHEA_ID":44920,"compounds":"(2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + H(+) + NADPH = (3E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + NADP(+)"}
{"X":46515,"RHEA_ID":54904,"compounds":"(2E,9Z)-hexadecadienoyl-[ACP] + H(+) + NADH = (9Z)-hexadecenoyl-[ACP] + NAD(+)"}
{"X":46516,"RHEA_ID":54905,"compounds":"(2E,9Z)-hexadecadienoyl-[ACP] + H(+) + NADH => (9Z)-hexadecenoyl-[ACP] + NAD(+)"}
{"X":46517,"RHEA_ID":44923,"compounds":"(2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + H(+) + NADPH <=> (3E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + NADP(+)"}
{"X":46518,"RHEA_ID":44924,"compounds":"2-oxoadipate + acetyl-CoA + H2O = (R)-dihomocitrate + CoA + H(+)"}
{"X":46519,"RHEA_ID":54908,"compounds":"(2E,4E)-hexadienoyl-CoA + H(+) + NADPH = (4E)-hexenoyl-CoA + NADP(+)"}
{"X":46520,"RHEA_ID":44926,"compounds":"(R)-dihomocitrate + CoA + H(+) => 2-oxoadipate + acetyl-CoA + H2O"}
{"X":46521,"RHEA_ID":54910,"compounds":"(4E)-hexenoyl-CoA + NADP(+) => (2E,4E)-hexadienoyl-CoA + H(+) + NADPH"}
{"X":46522,"RHEA_ID":44928,"compounds":"2-oxoheptanedioate + acetyl-CoA + H2O = (R)-trihomocitrate + CoA + H(+)"}
{"X":46523,"RHEA_ID":54912,"compounds":"11-cis-retinol + NADP(+) = 11-cis-retinal + H(+) + NADPH"}
{"X":46524,"RHEA_ID":54913,"DIRECTION":"LR","MASTER_ID":54912,"reactome":"R-HSA-2465921.3","compounds":"11-cis-retinol + NADP(+) => 11-cis-retinal + H(+) + NADPH"}
{"X":46525,"RHEA_ID":54914,"compounds":"11-cis-retinal + H(+) + NADPH => 11-cis-retinol + NADP(+)"}
{"X":46526,"RHEA_ID":44932,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + ATP + CoA = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + AMP + diphosphate"}
{"X":46527,"RHEA_ID":44933,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + ATP + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + AMP + diphosphate"}
{"X":46528,"RHEA_ID":44934,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + AMP + diphosphate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + ATP + CoA"}
{"X":46529,"RHEA_ID":44935,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + ATP + CoA <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + AMP + diphosphate"}
{"X":46530,"RHEA_ID":44936,"compounds":"(9Z,12Z,15Z)-octadecatrienoate + ATP + CoA = (9Z,12Z,15Z)-octadecatrienoyl-CoA + AMP + diphosphate"}
{"X":46531,"RHEA_ID":54920,"compounds":"13-cis-retinol + NADP(+) = 13-cis-retinal + H(+) + NADPH"}
{"X":46532,"RHEA_ID":54921,"compounds":"13-cis-retinol + NADP(+) => 13-cis-retinal + H(+) + NADPH"}
{"X":46533,"RHEA_ID":44939,"compounds":"(9Z,12Z,15Z)-octadecatrienoate + ATP + CoA <=> (9Z,12Z,15Z)-octadecatrienoyl-CoA + AMP + diphosphate"}
{"X":46534,"RHEA_ID":44940,"compounds":"1-O-alkyl-2,3-diacyl-sn-glycerol + H2O = 1-O-alkyl-3-acyl-sn-glycerol + a fatty acid + H(+)"}
{"X":46535,"RHEA_ID":54924,"compounds":"(7Z)-tetradecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(9Z)-hexadecenoyl-[ACP] + CO2 + holo-[ACP]"}
{"X":46536,"RHEA_ID":54925,"compounds":"(7Z)-tetradecenoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxo-(9Z)-hexadecenoyl-[ACP] + CO2 + holo-[ACP]"}
{"X":46537,"RHEA_ID":44943,"compounds":"1-O-alkyl-2,3-diacyl-sn-glycerol + H2O <=> 1-O-alkyl-3-acyl-sn-glycerol + a fatty acid + H(+)"}
{"X":46538,"RHEA_ID":44944,"compounds":"1-O-alkyl-3-acyl-sn-glycerol + H2O = 1-O-alkyl-sn-glycerol + a fatty acid + H(+)"}
{"X":46539,"RHEA_ID":54928,"compounds":"3-oxo-(9Z)-hexadecenoyl-[ACP] + H(+) + NADPH = (3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] + NADP(+)"}
{"X":46540,"RHEA_ID":54929,"compounds":"3-oxo-(9Z)-hexadecenoyl-[ACP] + H(+) + NADPH => (3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] + NADP(+)"}
{"X":46541,"RHEA_ID":44947,"compounds":"1-O-alkyl-3-acyl-sn-glycerol + H2O <=> 1-O-alkyl-sn-glycerol + a fatty acid + H(+)"}
{"X":46542,"RHEA_ID":44948,"compounds":"1-O-alkyl-2,3-diacyl-sn-glycerol + H2O = 1-O-alkyl-2-acyl-sn-glycerol + a fatty acid + H(+)"}
{"X":46543,"RHEA_ID":54932,"compounds":"(3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] = (2E,9Z)-hexadecadienoyl-[ACP] + H2O"}
{"X":46544,"RHEA_ID":44950,"compounds":"1-O-alkyl-2-acyl-sn-glycerol + a fatty acid + H(+) => 1-O-alkyl-2,3-diacyl-sn-glycerol + H2O"}
{"X":46545,"RHEA_ID":54934,"compounds":"(2E,9Z)-hexadecadienoyl-[ACP] + H2O => (3R)-hydroxy-(9Z)-hexadecenoyl-[ACP]"}
{"X":46546,"RHEA_ID":44952,"compounds":"(2E)-octenoyl-CoA + H(+) + NADPH = NADP(+) + octanoyl-CoA"}
{"X":46547,"RHEA_ID":54936,"compounds":"(2E)-decenoyl-[ACP] + H(+) + NADH = decanoyl-[ACP] + NAD(+)"}
{"X":46548,"RHEA_ID":48253,"compounds":"ganglioside GD2 + UDP-alpha-D-galactose => ganglioside GD1b + H(+) + UDP"}
{"X":46549,"RHEA_ID":54938,"compounds":"decanoyl-[ACP] + NAD(+) => (2E)-decenoyl-[ACP] + H(+) + NADH"}
{"X":46550,"RHEA_ID":44956,"compounds":"(2E)-hexenoyl-CoA + H(+) + NADPH = hexanoyl-CoA + NADP(+)"}
{"X":46551,"RHEA_ID":44957,"compounds":"(2E)-hexenoyl-CoA + H(+) + NADPH => hexanoyl-CoA + NADP(+)"}
{"X":46552,"RHEA_ID":48257,"compounds":"(2S)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-2-methylbutenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":46553,"RHEA_ID":54942,"compounds":"3-oxo-(5Z)-dodecenoyl-[ACP] + CO2 + holo-[ACP] => (3Z)-decenoyl-[ACP] + H(+) + malonyl-[ACP]"}
{"X":46554,"RHEA_ID":44960,"compounds":"(2E)-decenoyl-CoA + H(+) + NADPH = decanoyl-CoA + NADP(+)"}
{"X":46555,"RHEA_ID":44961,"DIRECTION":"LR","MASTER_ID":44960,"reactome":"R-HSA-8952873.1","compounds":"(2E)-decenoyl-CoA + H(+) + NADPH => decanoyl-CoA + NADP(+)"}
{"X":46556,"RHEA_ID":44962,"compounds":"decanoyl-CoA + NADP(+) => (2E)-decenoyl-CoA + H(+) + NADPH"}
{"X":46557,"RHEA_ID":44963,"compounds":"(2E)-decenoyl-CoA + H(+) + NADPH <=> decanoyl-CoA + NADP(+)"}
{"X":46558,"RHEA_ID":54947,"compounds":"3-oxo-(5Z)-dodecenoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxy-(5Z)-dodecenoyl-[ACP] + NADP(+)"}
{"X":46559,"RHEA_ID":54948,"compounds":"(3R)-hydroxy-(5Z)-dodecenoyl-[ACP] = (2E,5Z)-dodecadienoyl-[ACP] + H2O"}
{"X":46560,"RHEA_ID":48265,"DIRECTION":"LR","MASTER_ID":48264,"metacyc":"RXN-11952","compounds":"H2O + S-sulfosulfanyl-L-cysteinyl-[SoxY protein] => H(+) + S-sulfanyl-L-cysteinyl-[SoxY protein] + sulfate"}
{"X":46561,"RHEA_ID":44967,"compounds":"(2E)-dodecenoyl-CoA + H(+) + NADPH <=> dodecanoyl-CoA + NADP(+)"}
{"X":46562,"RHEA_ID":44968,"compounds":"(2E)-tetradecenoyl-CoA + H(+) + NADPH = NADP(+) + tetradecanoyl-CoA"}
{"X":46563,"RHEA_ID":54952,"compounds":"ATP + CoA + nonanoate = AMP + diphosphate + nonanoyl-CoA"}
{"X":46564,"RHEA_ID":44970,"compounds":"NADP(+) + tetradecanoyl-CoA => (2E)-tetradecenoyl-CoA + H(+) + NADPH"}
{"X":46565,"RHEA_ID":44971,"compounds":"(2E)-tetradecenoyl-CoA + H(+) + NADPH <=> NADP(+) + tetradecanoyl-CoA"}
{"X":46566,"RHEA_ID":44972,"compounds":"(R)-carnitine + hexanoyl-CoA = CoA + O-hexanoyl-(R)-carnitine"}
{"X":46567,"RHEA_ID":54956,"compounds":"ATP + CoA + OPC-6 = AMP + diphosphate + OPC-6-CoA"}
{"X":46568,"RHEA_ID":54957,"compounds":"ATP + CoA + OPC-6 => AMP + diphosphate + OPC-6-CoA"}
{"X":46569,"RHEA_ID":54958,"compounds":"AMP + diphosphate + OPC-6-CoA => ATP + CoA + OPC-6"}
{"X":46570,"RHEA_ID":44976,"compounds":"(R)-carnitine + propanoyl-CoA = CoA + O-propanoyl-(R)-carnitine"}
{"X":46571,"RHEA_ID":54960,"compounds":"ATP + CoA + dinor-OPDA = AMP + dinor-OPDA-CoA + diphosphate"}
{"X":46572,"RHEA_ID":54961,"compounds":"ATP + CoA + dinor-OPDA => AMP + dinor-OPDA-CoA + diphosphate"}
{"X":46573,"RHEA_ID":44979,"compounds":"(R)-carnitine + propanoyl-CoA <=> CoA + O-propanoyl-(R)-carnitine"}
{"X":46574,"RHEA_ID":44980,"compounds":"(R)-carnitine + butanoyl-CoA = CoA + O-butanoyl-(R)-carnitine"}
{"X":46575,"RHEA_ID":54964,"compounds":"hexadecanoyl-[ACP] + phosphate = hexadecanoyl phosphate + holo-[ACP]"}
{"X":46576,"RHEA_ID":54965,"compounds":"hexadecanoyl-[ACP] + phosphate => hexadecanoyl phosphate + holo-[ACP]"}
{"X":46577,"RHEA_ID":44983,"compounds":"(R)-carnitine + butanoyl-CoA <=> CoA + O-butanoyl-(R)-carnitine"}
{"X":46578,"RHEA_ID":44984,"compounds":"(R)-carnitine + 3-methylbutanoyl-CoA = CoA + O-3-methylbutanoyl-(R)-carnitine"}
{"X":46579,"RHEA_ID":54968,"compounds":"hexadecanoyl phosphate + sn-glycerol 3-phosphate = 1-hexadecanoyl-sn-glycero-3-phosphate + phosphate"}
{"X":46580,"RHEA_ID":44986,"compounds":"CoA + O-3-methylbutanoyl-(R)-carnitine => (R)-carnitine + 3-methylbutanoyl-CoA"}
{"X":46581,"RHEA_ID":44987,"compounds":"(R)-carnitine + 3-methylbutanoyl-CoA <=> CoA + O-3-methylbutanoyl-(R)-carnitine"}
{"X":46582,"RHEA_ID":44988,"compounds":"(R)-carnitine + 2-methylpropanoyl-CoA = CoA + O-isobutanoyl-(R)-carnitine"}
{"X":46583,"RHEA_ID":54972,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-[ACP] = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + holo-[ACP]"}
{"X":46584,"RHEA_ID":54973,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-[ACP] => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + holo-[ACP]"}
{"X":46585,"RHEA_ID":44991,"compounds":"(R)-carnitine + 2-methylpropanoyl-CoA <=> CoA + O-isobutanoyl-(R)-carnitine"}
{"X":46586,"RHEA_ID":44992,"compounds":"(R)-carnitine + 2-methylbutanoyl-CoA = CoA + O-2-methylbutanoyl-(R)-carnitine"}
{"X":46587,"RHEA_ID":54976,"compounds":"(3S)-hydroxytetradecanoyl-CoA + H2O = (3S)-hydroxytetradecanoate + CoA + H(+)"}
{"X":46588,"RHEA_ID":44994,"compounds":"CoA + O-2-methylbutanoyl-(R)-carnitine => (R)-carnitine + 2-methylbutanoyl-CoA"}
{"X":46589,"RHEA_ID":54978,"compounds":"(3S)-hydroxytetradecanoate + CoA + H(+) => (3S)-hydroxytetradecanoyl-CoA + H2O"}
{"X":46590,"RHEA_ID":44996,"compounds":"(R)-carnitine + acetoacetyl-CoA = CoA + O-3-oxobutanoyl-(R)-carnitine"}
{"X":46591,"RHEA_ID":44997,"compounds":"(R)-carnitine + acetoacetyl-CoA => CoA + O-3-oxobutanoyl-(R)-carnitine"}
{"X":46592,"RHEA_ID":54981,"compounds":"alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-di-trans,octa-cis-undecaprenol + 2 GDP-alpha-D-mannose => [alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n+1)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenol + 2 GDP + 2 H(+)"}
{"X":46593,"RHEA_ID":44999,"compounds":"(R)-carnitine + acetoacetyl-CoA <=> CoA + O-3-oxobutanoyl-(R)-carnitine"}
{"X":46594,"RHEA_ID":45000,"compounds":"(R)-carnitine + 3-hydroxybutanoyl-CoA = CoA + O-3-hydroxybutanoyl-(R)-carnitine"}
{"X":46595,"RHEA_ID":54984,"compounds":"a ubiquinol = a ubiquinone + 2 e(-) + 2 H(+)"}
{"X":46596,"RHEA_ID":45002,"compounds":"CoA + O-3-hydroxybutanoyl-(R)-carnitine => (R)-carnitine + 3-hydroxybutanoyl-CoA"}
{"X":46597,"RHEA_ID":54986,"compounds":"a ubiquinone + 2 e(-) + 2 H(+) => a ubiquinol"}
{"X":46598,"RHEA_ID":45004,"compounds":"(R)-carnitine + 2,6-dimethylheptanoyl-CoA = CoA + O-2,6-dimethylheptanoyl-(R)-carnitine"}
{"X":46599,"RHEA_ID":54988,"compounds":"4 e(-) + 4 H(+)(in) + O2(in) = 2 H2O(in)"}
{"X":46600,"RHEA_ID":45006,"compounds":"CoA + O-2,6-dimethylheptanoyl-(R)-carnitine => (R)-carnitine + 2,6-dimethylheptanoyl-CoA"}
{"X":46601,"RHEA_ID":45007,"compounds":"(R)-carnitine + 2,6-dimethylheptanoyl-CoA <=> CoA + O-2,6-dimethylheptanoyl-(R)-carnitine"}
{"X":46602,"RHEA_ID":45008,"compounds":"H2O + N-(octadecanoyl)-sphinganine = octadecanoate + sphinganine"}
{"X":46603,"RHEA_ID":45009,"compounds":"H2O + N-(octadecanoyl)-sphinganine => octadecanoate + sphinganine"}
{"X":46604,"RHEA_ID":45010,"compounds":"octadecanoate + sphinganine => H2O + N-(octadecanoyl)-sphinganine"}
{"X":46605,"RHEA_ID":54994,"compounds":"2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 3 AH2 + CO2 + H(+) => 3 A + FMN + H2O + L-glutamate + O2"}
{"X":46606,"RHEA_ID":45012,"compounds":"H2O + N-(octadecanoyl)-4-hydroxysphinganine = 4-hydroxysphinganine + octadecanoate"}
{"X":46607,"RHEA_ID":54996,"DIRECTION":"UN","MASTER_ID":54996,"ec":"2.4.1.226","compounds":"3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP"}
{"X":46608,"RHEA_ID":45014,"compounds":"4-hydroxysphinganine + octadecanoate => H2O + N-(octadecanoyl)-4-hydroxysphinganine"}
{"X":46609,"RHEA_ID":54998,"compounds":"3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate"}
{"X":46610,"RHEA_ID":45016,"DIRECTION":"UN","MASTER_ID":45016,"ec":"2.1.1.14","compounds":"5-methyltetrahydropteroyltri-L-glutamate + L-selenohomocysteine = L-selenomethionine + tetrahydropteroyltri-L-glutamate"}
{"X":46611,"RHEA_ID":45017,"DIRECTION":"LR","MASTER_ID":45016,"metacyc":"RXN-12730","compounds":"5-methyltetrahydropteroyltri-L-glutamate + L-selenohomocysteine => L-selenomethionine + tetrahydropteroyltri-L-glutamate"}
{"X":46612,"RHEA_ID":45018,"compounds":"L-selenomethionine + tetrahydropteroyltri-L-glutamate => 5-methyltetrahydropteroyltri-L-glutamate + L-selenohomocysteine"}
{"X":46613,"RHEA_ID":48318,"compounds":"CMP + ganglioside GD1aalpha + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM1b"}
{"X":46614,"RHEA_ID":45020,"DIRECTION":"UN","MASTER_ID":45020,"ec":"2.1.1.298","compounds":"L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-homocysteine"}
{"X":46615,"RHEA_ID":45021,"DIRECTION":"LR","MASTER_ID":45020,"ecocyc":"RXN0-1241","metacyc":"RXN0-1241","compounds":"L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-methionine => H(+) + N(5)-methyl-L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-homocysteine"}
{"X":46616,"RHEA_ID":45022,"compounds":"H(+) + N(5)-methyl-L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-homocysteine => L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-methionine"}
{"X":46617,"RHEA_ID":45023,"compounds":"L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-methionine <=> H(+) + N(5)-methyl-L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-homocysteine"}
{"X":46618,"RHEA_ID":55007,"compounds":"1-hydroxylimonen-2-one + NADPH + O2 <=> 3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)"}
{"X":46619,"RHEA_ID":45025,"DIRECTION":"LR","MASTER_ID":45024,"metacyc":"RXN-16379","compounds":"cholesterol + H(+) + NADPH + O2 => cholesta-5,7-dien-3beta-ol + 2 H2O + NADP(+)"}
{"X":46620,"RHEA_ID":45026,"compounds":"cholesta-5,7-dien-3beta-ol + 2 H2O + NADP(+) => cholesterol + H(+) + NADPH + O2"}
{"X":46621,"RHEA_ID":55010,"compounds":"(3S)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+) => (1R,4S)-1-hydroxylimonen-2-one + NADPH + O2"}
{"X":46622,"RHEA_ID":55011,"compounds":"(1R,4S)-1-hydroxylimonen-2-one + NADPH + O2 <=> (3S)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)"}
{"X":46623,"RHEA_ID":45029,"DIRECTION":"LR","MASTER_ID":45028,"metacyc":"RXN-8959","compounds":"(2S)-methylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => 2-methylfumaryl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":46624,"RHEA_ID":45030,"compounds":"2-methylfumaryl-CoA + reduced [electron-transfer flavoprotein] => (2S)-methylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":46625,"RHEA_ID":55014,"compounds":"(3R)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+) => (1S,4R)-1-hydroxylimonen-2-one + NADPH + O2"}
{"X":46626,"RHEA_ID":48331,"compounds":"a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose <=> GDP + H(+) + III(4)-a-Fuc-Lc4Cer(d18:1(4E))"}
{"X":46627,"RHEA_ID":45033,"DIRECTION":"LR","MASTER_ID":45032,"metacyc":"HAONITRO-RXN","compounds":"4 [Fe(III)cytochrome c] + H2O + hydroxylamine => 4 [Fe(II)cytochrome c] + 5 H(+) + nitrite"}
{"X":46628,"RHEA_ID":45034,"compounds":"4 [Fe(II)cytochrome c] + 5 H(+) + nitrite => 4 [Fe(III)cytochrome c] + H2O + hydroxylamine"}
{"X":46629,"RHEA_ID":55019,"compounds":"H(+) + menthone + NADPH + O2 <=> 7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)"}
{"X":46630,"RHEA_ID":45037,"DIRECTION":"LR","MASTER_ID":45036,"metacyc":"RXN-13570","compounds":"3 [Fe(III)cytochrome c] + hydroxylamine => 3 [Fe(II)cytochrome c] + 3 H(+) + nitric oxide"}
{"X":46631,"RHEA_ID":45038,"compounds":"3 [Fe(II)cytochrome c] + 3 H(+) + nitric oxide => 3 [Fe(III)cytochrome c] + hydroxylamine"}
{"X":46632,"RHEA_ID":55022,"compounds":"5,6-diaminouracil + D-ribose 5-phosphate => 5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O"}
{"X":46633,"RHEA_ID":45040,"compounds":"2 [Fe(III)cytochrome c] + hydroxylamine = 2 [Fe(II)cytochrome c] + 2 H(+) + nitroxyl"}
{"X":46634,"RHEA_ID":45041,"DIRECTION":"LR","MASTER_ID":45040,"metacyc":"RXN-16318","compounds":"2 [Fe(III)cytochrome c] + hydroxylamine => 2 [Fe(II)cytochrome c] + 2 H(+) + nitroxyl"}
{"X":46635,"RHEA_ID":45042,"compounds":"2 [Fe(II)cytochrome c] + 2 H(+) + nitroxyl => 2 [Fe(III)cytochrome c] + hydroxylamine"}
{"X":46636,"RHEA_ID":48343,"compounds":"a medium chain fatty acid + ATP + CoA <=> a medium-chain fatty acyl-CoA + AMP + diphosphate"}
{"X":46637,"RHEA_ID":45045,"DIRECTION":"LR","MASTER_ID":45044,"metacyc":"RXN-16319","compounds":"2 [Fe(II)cytochrome c] + H(+) + nitroxyl + O2 => 2 [Fe(III)cytochrome c] + H2O + nitrite"}
{"X":46638,"RHEA_ID":45046,"compounds":"2 [Fe(III)cytochrome c] + H2O + nitrite => 2 [Fe(II)cytochrome c] + H(+) + nitroxyl + O2"}
{"X":46639,"RHEA_ID":58372,"compounds":"(E)-oct-2-en-1-ol + NADP(+) = (2E)-octenal + H(+) + NADPH"}
{"X":46640,"RHEA_ID":48347,"compounds":"N-acyl-sphingoid base + UDP-alpha-D-galactose <=> a D-galactosylceramide + H(+) + UDP"}
{"X":46641,"RHEA_ID":45049,"compounds":"acetamide + H2O => acetate + NH4(+)"}
{"X":46642,"RHEA_ID":45050,"compounds":"acetate + NH4(+) => acetamide + H2O"}
{"X":46643,"RHEA_ID":48350,"compounds":"a pseudouridine in RNA => a uridine in RNA"}
{"X":46644,"RHEA_ID":48351,"compounds":"a uridine in RNA <=> a pseudouridine in RNA"}
{"X":46645,"RHEA_ID":45053,"compounds":"(2E)-butenoyl-CoA + (R)-carnitine => CoA + O-(2E)-butenoyl-(R)-carnitine"}
{"X":46646,"RHEA_ID":45054,"compounds":"CoA + O-(2E)-butenoyl-(R)-carnitine => (2E)-butenoyl-CoA + (R)-carnitine"}
{"X":46647,"RHEA_ID":45055,"compounds":"(2E)-butenoyl-CoA + (R)-carnitine <=> CoA + O-(2E)-butenoyl-(R)-carnitine"}
{"X":46648,"RHEA_ID":48355,"compounds":"GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide <=> GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide"}
{"X":46649,"RHEA_ID":55040,"compounds":"(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]"}
{"X":46650,"RHEA_ID":45058,"compounds":"H(+) + H2O + nogalonate => deoxynogalonate + O2"}
{"X":46651,"RHEA_ID":55042,"compounds":"3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP] => (9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP]"}
{"X":46652,"RHEA_ID":55043,"compounds":"(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]"}
{"X":46653,"RHEA_ID":55044,"compounds":"(3E,5Z)-tetradecadienoyl-CoA + H2O = (3E,5Z)-tetradecadienoate + CoA + H(+)"}
{"X":46654,"RHEA_ID":45062,"compounds":"(9Z)-octadecenoate + ethanolamine => H2O + N-(9Z-octadecenoyl) ethanolamine"}
{"X":46655,"RHEA_ID":55046,"compounds":"(3E,5Z)-tetradecadienoate + CoA + H(+) => (3E,5Z)-tetradecadienoyl-CoA + H2O"}
{"X":46656,"RHEA_ID":55047,"compounds":"(3E,5Z)-tetradecadienoyl-CoA + H2O <=> (3E,5Z)-tetradecadienoate + CoA + H(+)"}
{"X":46657,"RHEA_ID":55048,"compounds":"(3E,5Z)-dodecadienoyl-CoA + H2O = (3E,5Z)-dodecadienoate + CoA + H(+)"}
{"X":46658,"RHEA_ID":45066,"compounds":"ethanolamine + hexadecanoate => H2O + N-hexadecanoylethanolamine"}
{"X":46659,"RHEA_ID":55050,"compounds":"(3E,5Z)-dodecadienoate + CoA + H(+) => (3E,5Z)-dodecadienoyl-CoA + H2O"}
{"X":46660,"RHEA_ID":55051,"compounds":"(3E,5Z)-dodecadienoyl-CoA + H2O <=> (3E,5Z)-dodecadienoate + CoA + H(+)"}
{"X":46661,"RHEA_ID":55052,"compounds":"H2O + pentanoyl-CoA = CoA + H(+) + pentanoate"}
{"X":46662,"RHEA_ID":45070,"compounds":"CoA + O-acyl-(R)-carnitine => (R)-carnitine + an acyl-CoA"}
{"X":46663,"RHEA_ID":45071,"compounds":"(R)-carnitine + an acyl-CoA <=> CoA + O-acyl-(R)-carnitine"}
{"X":46664,"RHEA_ID":55055,"compounds":"H2O + pentanoyl-CoA <=> CoA + H(+) + pentanoate"}
{"X":46665,"RHEA_ID":45073,"DIRECTION":"LR","MASTER_ID":45072,"metacyc":"RXN-1063","compounds":"(9Z)-octadecenoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase] => (9Z)-18-hydroxyoctadecenoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":46666,"RHEA_ID":45074,"compounds":"(9Z)-18-hydroxyoctadecenoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z)-octadecenoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":46667,"RHEA_ID":55060,"compounds":"a 12-hydroxyjasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase] = a 12-oxojasmonyl-L-alpha-amino acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":46668,"RHEA_ID":45078,"compounds":"(9Z,12Z)-18-hydroxyoctadecadienoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z,12Z)-octadecadienoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":46669,"RHEA_ID":55064,"compounds":"4-methylpentanoyl-CoA + H2O = 4-methylpentanoate + CoA + H(+)"}
{"X":46670,"RHEA_ID":45082,"compounds":"ADP + dapdiamide E + H(+) + phosphate => 3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine + ATP + L-valine"}
{"X":46671,"RHEA_ID":55066,"compounds":"4-methylpentanoate + CoA + H(+) => 4-methylpentanoyl-CoA + H2O"}
{"X":46672,"RHEA_ID":55067,"compounds":"4-methylpentanoyl-CoA + H2O <=> 4-methylpentanoate + CoA + H(+)"}
{"X":46673,"RHEA_ID":55068,"compounds":"a 12-oxojasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase] = a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":46674,"RHEA_ID":45086,"compounds":"7-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":46675,"RHEA_ID":58412,"DIRECTION":"UN","MASTER_ID":58412,"ec":"2.8.1.16","compounds":"3 H(+) + hydrogen sulfide + L-aspartate 4-semialdehyde + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + L-homocysteine + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":46676,"RHEA_ID":45088,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine = 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline"}
{"X":46677,"RHEA_ID":45089,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine => 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline"}
{"X":46678,"RHEA_ID":45090,"compounds":"1,2-diacyl-sn-glycero-3-phospho-L-serine + choline => a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine"}
{"X":46679,"RHEA_ID":55074,"compounds":"CO2 + propanal => 2-oxobutanoate + H(+)"}
{"X":46680,"RHEA_ID":55075,"compounds":"2-oxobutanoate + H(+) <=> CO2 + propanal"}
{"X":46681,"RHEA_ID":45093,"compounds":"H2O + N-octanoylsphing-4-enine => octanoate + sphing-4-enine"}
{"X":46682,"RHEA_ID":45094,"compounds":"octanoate + sphing-4-enine => H2O + N-octanoylsphing-4-enine"}
{"X":46683,"RHEA_ID":45095,"compounds":"H2O + N-octanoylsphing-4-enine <=> octanoate + sphing-4-enine"}
{"X":46684,"RHEA_ID":45096,"DIRECTION":"UN","MASTER_ID":45096,"ec":"1.14.19.6","compounds":"(9Z)-hexadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (9Z,12Z)-hexadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":46685,"RHEA_ID":48396,"compounds":"(3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + S-adenosyl-L-methionine = 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one + H(+) + S-adenosyl-L-homocysteine"}
{"X":46686,"RHEA_ID":45098,"compounds":"(9Z,12Z)-hexadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => (9Z)-hexadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}
{"X":46687,"RHEA_ID":45100,"DIRECTION":"UN","MASTER_ID":45100,"ec":"2.1.1.316","compounds":"6-demethylmitomycin B + S-adenosyl-L-methionine = mitomycin B + S-adenosyl-L-homocysteine"}
{"X":46688,"RHEA_ID":48400,"DIRECTION":"UN","MASTER_ID":48400,"ec":"1.14.11.29","compounds":"2-oxoglutarate + [hypoxia-inducible factor alpha subunit]-L-proline + O2 = [hypoxia-inducible factor alpha subunit]-trans-4-hydroxy-L-proline + CO2 + succinate"}
{"X":46689,"RHEA_ID":45102,"compounds":"mitomycin B + S-adenosyl-L-homocysteine => 6-demethylmitomycin B + S-adenosyl-L-methionine"}
{"X":46690,"RHEA_ID":55086,"compounds":"(3R)-hydroxypentanoate + CoA + H(+) => (3R)-hydroxypentanoyl-CoA + H2O"}
{"X":46691,"RHEA_ID":45104,"DIRECTION":"UN","MASTER_ID":45104,"ec":"2.1.1.316","compounds":"6-demethylmitomycin A + S-adenosyl-L-methionine = mitomycin A + S-adenosyl-L-homocysteine"}
{"X":46692,"RHEA_ID":55088,"compounds":"24-methylene-24-dihydrolanosterol + S-adenosyl-L-methionine = (24Z)-ethylidenelanosterol + H(+) + S-adenosyl-L-homocysteine"}
{"X":46693,"RHEA_ID":45106,"compounds":"mitomycin A + S-adenosyl-L-homocysteine => 6-demethylmitomycin A + S-adenosyl-L-methionine"}
{"X":46694,"RHEA_ID":55090,"compounds":"(24Z)-ethylidenelanosterol + H(+) + S-adenosyl-L-homocysteine => 24-methylene-24-dihydrolanosterol + S-adenosyl-L-methionine"}
{"X":46695,"RHEA_ID":45108,"compounds":"(+)-alpha-tocopherol + O2 + reduced [NADPH--hemoprotein reductase] = 13-hydroxy-alpha-tocopherol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":46696,"RHEA_ID":55092,"DIRECTION":"UN","MASTER_ID":55092,"ec":"2.4.1.13","compounds":"D-fructose + UDP-alpha-D-glucose = H(+) + sucrose + UDP"}
{"X":46697,"RHEA_ID":45110,"compounds":"13-hydroxy-alpha-tocopherol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-alpha-tocopherol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":46698,"RHEA_ID":45111,"compounds":"(+)-alpha-tocopherol + O2 + reduced [NADPH--hemoprotein reductase] <=> 13-hydroxy-alpha-tocopherol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":46699,"RHEA_ID":45112,"compounds":"gamma-tocopherol + H(+) + NADPH + O2 = 13-hydroxy-gamma-tocopherol + H2O + NADP(+)"}
{"X":46700,"RHEA_ID":55096,"compounds":"(3S)-hydroxypentanoyl-CoA + H2O = (3S)-hydroxypentanoate + CoA + H(+)"}
{"X":46701,"RHEA_ID":45114,"compounds":"13-hydroxy-gamma-tocopherol + H2O + NADP(+) => gamma-tocopherol + H(+) + NADPH + O2"}
{"X":46702,"RHEA_ID":45115,"compounds":"gamma-tocopherol + H(+) + NADPH + O2 <=> 13-hydroxy-gamma-tocopherol + H2O + NADP(+)"}
{"X":46703,"RHEA_ID":45116,"DIRECTION":"UN","MASTER_ID":45116,"ec":"1.1.1.386","compounds":"(4R)-ipsdienol + NADP(+) = H(+) + ipsdienone + NADPH"}
{"X":46704,"RHEA_ID":58442,"compounds":"3 H(+) + N-terminal N,N,N-trimethyl-L-glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-homocysteine => N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-methionine"}
{"X":46705,"RHEA_ID":45118,"compounds":"H(+) + ipsdienone + NADPH => (4R)-ipsdienol + NADP(+)"}
{"X":46706,"RHEA_ID":55102,"compounds":"(3R)-hydroxypentanoyl-[ACP] + NADP(+) => 3-oxopentanoyl-[ACP] + H(+) + NADPH"}
{"X":46707,"RHEA_ID":45120,"DIRECTION":"UN","MASTER_ID":45120,"ec":"1.1.1.386","compounds":"(4R)-ipsdienol + NAD(+) = H(+) + ipsdienone + NADH"}
{"X":46708,"RHEA_ID":58446,"compounds":"H(+) + N-terminal N-methyl-L-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine => N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine"}
{"X":46709,"RHEA_ID":45122,"compounds":"H(+) + ipsdienone + NADH => (4R)-ipsdienol + NAD(+)"}
{"X":46710,"RHEA_ID":55106,"compounds":"(3R)-hydroxyheptanoyl-[ACP] + NADP(+) => 3-oxoheptanoyl-[ACP] + H(+) + NADPH"}
{"X":46711,"RHEA_ID":45124,"DIRECTION":"UN","MASTER_ID":45124,"ec":"2.7.1.187","compounds":"acarbose + ATP = acarbose 7(IV)-phosphate + ADP + H(+)"}
{"X":46712,"RHEA_ID":48424,"compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H2O = (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dUMP"}
{"X":46713,"RHEA_ID":45126,"compounds":"acarbose 7(IV)-phosphate + ADP + H(+) => acarbose + ATP"}
{"X":46714,"RHEA_ID":48426,"compounds":"(6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dUMP => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H2O"}
{"X":46715,"RHEA_ID":45128,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)"}
{"X":46716,"RHEA_ID":55112,"compounds":"3-oxo-4-methylpentanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxy-4-methylpentanoyl-[ACP] + NADP(+)"}
{"X":46717,"RHEA_ID":45130,"compounds":"(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O"}
{"X":46718,"RHEA_ID":45131,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)"}
{"X":46719,"RHEA_ID":45132,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate"}
{"X":46720,"RHEA_ID":48432,"DIRECTION":"UN","MASTER_ID":48432,"ec":"2.7.1.172","compounds":"ATP + N(6)-D-ribulosyl-L-lysyl-[protein] = ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein]"}
{"X":46721,"RHEA_ID":45134,"compounds":"2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O"}
{"X":46722,"RHEA_ID":45135,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate"}
{"X":46723,"RHEA_ID":45136,"DIRECTION":"UN","MASTER_ID":45136,"ec":"4.2.1.160","compounds":"2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate = 7,8-dihydroneopterin 3'-phosphate + H2O"}
{"X":46724,"RHEA_ID":45137,"DIRECTION":"LR","MASTER_ID":45136,"metacyc":"RXN-15730","compounds":"2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate => 7,8-dihydroneopterin 3'-phosphate + H2O"}
{"X":46725,"RHEA_ID":45138,"compounds":"7,8-dihydroneopterin 3'-phosphate + H2O => 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate"}
{"X":46726,"RHEA_ID":48438,"compounds":"an aliphatic alcohol + H(+) + pentanoate => H2O + pentanoate ester"}
{"X":46727,"RHEA_ID":45140,"DIRECTION":"UN","MASTER_ID":45140,"ec":"4.1.1.90","compounds":"2,3-epoxyphylloquinone + 4-carboxy-L-glutamyl-[protein] + H(+) + H2O = CO2 + L-glutamyl-[protein] + O2 + phylloquinol"}
{"X":46728,"RHEA_ID":55124,"compounds":"(2E)-5-methylhexenoyl-[ACP] + H(+) + NADH = 5-methylhexanoyl-[ACP] + NAD(+)"}
{"X":46729,"RHEA_ID":45142,"DIRECTION":"RL","MASTER_ID":45140,"metacyc":"RXN-10683","compounds":"CO2 + L-glutamyl-[protein] + O2 + phylloquinol => 2,3-epoxyphylloquinone + 4-carboxy-L-glutamyl-[protein] + H(+) + H2O"}
{"X":46730,"RHEA_ID":48442,"compounds":"a fatty acid + H(+) + long chain 2-acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol => H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol"}
{"X":46731,"RHEA_ID":45144,"DIRECTION":"UN","MASTER_ID":45144,"ec":"4.2.1.155","compounds":"3-(methylsulfanyl)acryloyl-CoA + 2 H2O = acetaldehyde + CO2 + CoA + methanethiol"}
{"X":46732,"RHEA_ID":55128,"compounds":"(3R)-hydroxy-5-methylhexanoyl-[ACP] = (2E)-5-methylhexenoyl-[ACP] + H2O"}
{"X":46733,"RHEA_ID":45146,"compounds":"acetaldehyde + CO2 + CoA + methanethiol => 3-(methylsulfanyl)acryloyl-CoA + 2 H2O"}
{"X":46734,"RHEA_ID":48446,"compounds":"a fatty acid + H(+) + long chain 2-acyl-3-O-beta-D-galactosyl-sn-glycerol => H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol"}
{"X":46735,"RHEA_ID":45148,"compounds":"3-(methylsulfanyl)acryloyl-CoA + H2O = 3-hydroxy-3-(methylsulfanyl)propanoyl-CoA"}
{"X":46736,"RHEA_ID":55132,"DIRECTION":"UN","MASTER_ID":55132,"ec":"6.2.1.54","compounds":"ATP + D-alanine + holo-[D-alanyl-carrier protein] = AMP + D-alanyl-[D-alanyl-carrier protein] + diphosphate"}
{"X":46737,"RHEA_ID":48449,"compounds":"H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetyl-beta-D-galactosamine"}
{"X":46738,"RHEA_ID":48450,"compounds":"beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetyl-beta-D-galactosamine => H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide"}
{"X":46739,"RHEA_ID":45152,"compounds":"3-hydroxy-3-(methylsulfanyl)propanoyl-CoA = 3-oxopropanoyl-CoA + methanethiol"}
{"X":46740,"RHEA_ID":55136,"compounds":"ATP + D-alanine + H(+) = D-alanyl-5'-AMP + diphosphate"}
{"X":46741,"RHEA_ID":48453,"compounds":"ganglioside GA2 (d18:1(4E)) + H2O => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetyl-beta-D-galactosamine"}
{"X":46742,"RHEA_ID":48454,"compounds":"a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetyl-beta-D-galactosamine => ganglioside GA2 (d18:1(4E)) + H2O"}
{"X":46743,"RHEA_ID":45156,"compounds":"3-oxopropanoyl-CoA + H2O = 3-oxopropanoate + CoA + H(+)"}
{"X":46744,"RHEA_ID":55140,"compounds":"D-alanyl-5'-AMP + holo-[D-alanyl-carrier protein] = AMP + D-alanyl-[D-alanyl-carrier protein] + H(+)"}
{"X":46745,"RHEA_ID":45158,"compounds":"3-oxopropanoate + CoA + H(+) => 3-oxopropanoyl-CoA + H2O"}
{"X":46746,"RHEA_ID":48458,"compounds":"2-octanoyl-3-O-beta-D-galactosyl-sn-glycerol + H(+) + octanoate => 1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O"}
{"X":46747,"RHEA_ID":45160,"compounds":"3-oxopropanoate + H(+) = acetaldehyde + CO2"}
{"X":46748,"RHEA_ID":45161,"DIRECTION":"LR","MASTER_ID":45160,"metacyc":"RXN-16013","compounds":"3-oxopropanoate + H(+) => acetaldehyde + CO2"}
{"X":46749,"RHEA_ID":55145,"compounds":"[(3S)-4-(6-methylheptanoyl)-5-oxooxolan-3-yl]methyl phosphate + NADP(+) => [4-(6-methylheptanoyl)-5-oxo-2H-furan-3-yl]methyl phosphate + H(+) + NADPH"}
{"X":46750,"RHEA_ID":45164,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate"}
{"X":46751,"RHEA_ID":45165,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O => 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate"}
{"X":46752,"RHEA_ID":55149,"compounds":"a [(3S)-4-alkanoyl-5-oxooxolan-3-yl]methyl phosphate + NADP(+) => a (4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate + H(+) + NADPH"}
{"X":46753,"RHEA_ID":45167,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate"}
{"X":46754,"RHEA_ID":45169,"compounds":"2 sinapoyl-CoA + spermidine => 2 CoA + 2 H(+) + N(1),N(8)-bis(sinapoyl)-spermidine"}
{"X":46755,"RHEA_ID":45170,"compounds":"2 CoA + 2 H(+) + N(1),N(8)-bis(sinapoyl)-spermidine => 2 sinapoyl-CoA + spermidine"}
{"X":46756,"RHEA_ID":45171,"DIRECTION":"BI","MASTER_ID":45168,"metacyc":"RXN-16472","compounds":"2 sinapoyl-CoA + spermidine <=> 2 CoA + 2 H(+) + N(1),N(8)-bis(sinapoyl)-spermidine"}
{"X":46757,"RHEA_ID":45173,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine => 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":46758,"RHEA_ID":55157,"DIRECTION":"LR","MASTER_ID":55156,"metacyc":"RXN-19036","compounds":"a quinone + glutathione + H(+) + hydrogen sulfide => a quinol + S-sulfanylglutathione"}
{"X":46759,"RHEA_ID":45175,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine <=> 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":46760,"RHEA_ID":48475,"compounds":"ganglioside GT1a + H2O <=> ganglioside GD1a + N-acetylneuraminate"}
{"X":46761,"RHEA_ID":45177,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":46762,"RHEA_ID":55161,"compounds":"coenzyme B + coenzyme M + 2 oxidized [2Fe-2S]-[ferredoxin] => coenzyme M-coenzyme B heterodisulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":46763,"RHEA_ID":45179,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":46764,"RHEA_ID":45180,"DIRECTION":"UN","MASTER_ID":45180,"ec":"2.3.1.249","compounds":"2 (E)-4-coumaroyl-CoA + spermidine = 2 CoA + 2 H(+) + N(1),N(8)-bis(coumaroyl)-spermidine"}
{"X":46765,"RHEA_ID":45181,"compounds":"2 (E)-4-coumaroyl-CoA + spermidine => 2 CoA + 2 H(+) + N(1),N(8)-bis(coumaroyl)-spermidine"}
{"X":46766,"RHEA_ID":48481,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + UDP-alpha-D-galactose => 1,2-di-(9Z-octadecenoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP"}
{"X":46767,"RHEA_ID":48482,"compounds":"1,2-di-(9Z-octadecenoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + UDP-alpha-D-galactose"}
{"X":46768,"RHEA_ID":45184,"compounds":"5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + NH4(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + H2O"}
{"X":46769,"RHEA_ID":45185,"DIRECTION":"LR","MASTER_ID":45184,"ecocyc":"RXN-17900","metacyc":"RXN-17900","compounds":"5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + NH4(+) => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + H2O"}
{"X":46770,"RHEA_ID":45186,"compounds":"5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + H2O => 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + NH4(+)"}
{"X":46771,"RHEA_ID":48486,"compounds":"an aliphatic alcohol + H(+) + propanoate => a propanoate ester + H2O"}
{"X":46772,"RHEA_ID":45188,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine"}
{"X":46773,"RHEA_ID":45189,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine"}
{"X":46774,"RHEA_ID":45190,"compounds":"a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine"}
{"X":46775,"RHEA_ID":48490,"compounds":"all-trans-retinal--[retinol-binding protein] + H(+) + NADH => all-trans-retinol--[retinol-binding protein] + NAD(+)"}
{"X":46776,"RHEA_ID":45192,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 1-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine"}
{"X":46777,"RHEA_ID":45193,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine"}
{"X":46778,"RHEA_ID":45194,"compounds":"a 1-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine"}
{"X":46779,"RHEA_ID":55178,"compounds":"2-hydroxybutanoyl-CoA + CO2 + succinate => 2-oxoglutarate + butanoyl-CoA + O2"}
{"X":46780,"RHEA_ID":45196,"DIRECTION":"UN","MASTER_ID":45196,"ec":"2.1.1.245","compounds":"5,6,7,8-tetrahydrosarcinapterin + [methyl-Co(III) corrinoid Fe-S protein] = 5-methyltetrahydrosarcinapterin + [Co(I) corrinoid Fe-S protein] + H(+)"}
{"X":46781,"RHEA_ID":45197,"DIRECTION":"LR","MASTER_ID":45196,"metacyc":"RXN-12908","compounds":"5,6,7,8-tetrahydrosarcinapterin + [methyl-Co(III) corrinoid Fe-S protein] => 5-methyltetrahydrosarcinapterin + [Co(I) corrinoid Fe-S protein] + H(+)"}
{"X":46782,"RHEA_ID":45198,"compounds":"5-methyltetrahydrosarcinapterin + [Co(I) corrinoid Fe-S protein] + H(+) => 5,6,7,8-tetrahydrosarcinapterin + [methyl-Co(III) corrinoid Fe-S protein]"}
{"X":46783,"RHEA_ID":48498,"compounds":"1-(9Z-octadecenoyl)-2-hexadecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + UDP-alpha-D-galactose"}
{"X":46784,"RHEA_ID":45200,"DIRECTION":"UN","MASTER_ID":45200,"ec":"2.1.1.258","compounds":"(6S)-5,6,7,8-tetrahydrofolate + [methyl-Co(III) corrinoid Fe-S protein] = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + [Co(I) corrinoid Fe-S protein] + H(+)"}
{"X":46785,"RHEA_ID":45201,"compounds":"(6S)-5,6,7,8-tetrahydrofolate + [methyl-Co(III) corrinoid Fe-S protein] => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + [Co(I) corrinoid Fe-S protein] + H(+)"}
{"X":46786,"RHEA_ID":45202,"compounds":"(6S)-5-methyl-5,6,7,8-tetrahydrofolate + [Co(I) corrinoid Fe-S protein] + H(+) => (6S)-5,6,7,8-tetrahydrofolate + [methyl-Co(III) corrinoid Fe-S protein]"}
{"X":46787,"RHEA_ID":48502,"compounds":"glycerol + H(+) + octanoate => H2O + octanoylglycerol"}
{"X":46788,"RHEA_ID":45204,"DIRECTION":"UN","MASTER_ID":45204,"ec":"2.1.1.90","compounds":"[Co(I) methanol-specific corrinoid protein] + H(+) + methanol = [methyl-Co(III) methanol-specific corrinoid protein] + H2O"}
{"X":46789,"RHEA_ID":45205,"DIRECTION":"LR","MASTER_ID":45204,"metacyc":"RXN-8095","compounds":"[Co(I) methanol-specific corrinoid protein] + H(+) + methanol => [methyl-Co(III) methanol-specific corrinoid protein] + H2O"}
{"X":46790,"RHEA_ID":45206,"compounds":"[methyl-Co(III) methanol-specific corrinoid protein] + H2O => [Co(I) methanol-specific corrinoid protein] + H(+) + methanol"}
{"X":46791,"RHEA_ID":55190,"compounds":"5-methyl-2-thiouridine(54) in tRNA + AMP + diphosphate => 5-methyluridine(54) in tRNA + ATP + hydrogen sulfide"}
{"X":46792,"RHEA_ID":45208,"DIRECTION":"UN","MASTER_ID":45208,"ec":"2.1.1.246","compounds":"[methyl-Co(III) methanol-specific corrinoid protein] + coenzyme M = [Co(I) methanol-specific corrinoid protein] + H(+) + methyl-coenzyme M"}
{"X":46793,"RHEA_ID":45209,"compounds":"[methyl-Co(III) methanol-specific corrinoid protein] + coenzyme M => [Co(I) methanol-specific corrinoid protein] + H(+) + methyl-coenzyme M"}
{"X":46794,"RHEA_ID":45210,"compounds":"[Co(I) methanol-specific corrinoid protein] + H(+) + methyl-coenzyme M => [methyl-Co(III) methanol-specific corrinoid protein] + coenzyme M"}
{"X":46795,"RHEA_ID":48510,"compounds":"3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH => cholate + NADP(+)"}
{"X":46796,"RHEA_ID":45212,"DIRECTION":"UN","MASTER_ID":45212,"ec":"2.3.1.169","compounds":"[Co(I) corrinoid Fe-S protein] + acetyl-CoA + H(+) = [methyl-Co(III) corrinoid Fe-S protein] + CO + CoA"}
{"X":46797,"RHEA_ID":45213,"compounds":"[Co(I) corrinoid Fe-S protein] + acetyl-CoA + H(+) => [methyl-Co(III) corrinoid Fe-S protein] + CO + CoA"}
{"X":46798,"RHEA_ID":45214,"DIRECTION":"RL","MASTER_ID":45212,"metacyc":"ACETYLSYNCLTH-RXN","compounds":"[methyl-Co(III) corrinoid Fe-S protein] + CO + CoA => [Co(I) corrinoid Fe-S protein] + acetyl-CoA + H(+)"}
{"X":46799,"RHEA_ID":48514,"compounds":"ADP + H(+) + phosphate + phosphinate(in) => ATP + H2O + phosphinate(out)"}
{"X":46800,"RHEA_ID":55199,"compounds":"2-hydroxyoctadecanoyl-CoA <=> formyl-CoA + heptadecanal"}
{"X":46801,"RHEA_ID":45217,"DIRECTION":"LR","MASTER_ID":45216,"metacyc":"RXN-8101","compounds":"[methyl-Co(III) dimethylamine-specific corrinoid protein] + coenzyme M => [Co(I) dimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M"}
{"X":46802,"RHEA_ID":45218,"compounds":"[Co(I) dimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M => [methyl-Co(III) dimethylamine-specific corrinoid protein] + coenzyme M"}
{"X":46803,"RHEA_ID":55202,"compounds":"2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H(+) + L-methionine => 5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine"}
{"X":46804,"RHEA_ID":45220,"DIRECTION":"UN","MASTER_ID":45220,"ec":"2.1.1.247","compounds":"[methyl-Co(III) trimethylamine-specific corrinoid protein] + coenzyme M = [Co(I) trimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M"}
{"X":46805,"RHEA_ID":55204,"DIRECTION":"UN","MASTER_ID":55204,"ec":"4.3.1.32","compounds":"5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine = 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H(+) + L-methionine + NH4(+)"}
{"X":46806,"RHEA_ID":45222,"compounds":"[Co(I) trimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M => [methyl-Co(III) trimethylamine-specific corrinoid protein] + coenzyme M"}
{"X":46807,"RHEA_ID":45223,"compounds":"[methyl-Co(III) trimethylamine-specific corrinoid protein] + coenzyme M <=> [Co(I) trimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M"}
{"X":46808,"RHEA_ID":45224,"compounds":"(3E,5Z,8Z,11Z,14Z)-eicosapentaenoyl-CoA = (2E,4E,8Z,11Z,14Z)-eicosapentaenoyl-CoA"}
{"X":46809,"RHEA_ID":55208,"compounds":"4-hydroxysphinganine 1-phosphate = (2R)-hydroxyhexadecanal + phosphoethanolamine"}
{"X":46810,"RHEA_ID":45226,"compounds":"(2E,4E,8Z,11Z,14Z)-eicosapentaenoyl-CoA => (3E,5Z,8Z,11Z,14Z)-eicosapentaenoyl-CoA"}
{"X":46811,"RHEA_ID":55210,"compounds":"(2R)-hydroxyhexadecanal + phosphoethanolamine => 4-hydroxysphinganine 1-phosphate"}
{"X":46812,"RHEA_ID":45228,"DIRECTION":"UN","MASTER_ID":45228,"ec":"5.3.3.8","compounds":"a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA"}
{"X":46813,"RHEA_ID":45229,"compounds":"a (3E)-enoyl-CoA => a 4-saturated (2E)-enoyl-CoA"}
{"X":46814,"RHEA_ID":55213,"compounds":"(2R)-hydroxyhexadecanoyl-CoA => formyl-CoA + pentadecanal"}
{"X":46815,"RHEA_ID":45231,"DIRECTION":"BI","MASTER_ID":45228,"metacyc":"RXN-7836","compounds":"a (3E)-enoyl-CoA <=> a 4-saturated (2E)-enoyl-CoA"}
{"X":46816,"RHEA_ID":45232,"compounds":"a (2E,4Z)-dienoyl-CoA + H(+) + NADPH = a 4,5-saturated-(2E)-enoyl-CoA + NADP(+)"}
{"X":46817,"RHEA_ID":45233,"DIRECTION":"LR","MASTER_ID":45232,"metacyc":"RXN-20995","compounds":"a (2E,4Z)-dienoyl-CoA + H(+) + NADPH => a 4,5-saturated-(2E)-enoyl-CoA + NADP(+)"}
{"X":46818,"RHEA_ID":55217,"DIRECTION":"LR","MASTER_ID":55216,"metacyc":"RXN-19235","compounds":"all-trans-geranylgeranyl diphosphate => diphosphate + rhizathalene A"}
{"X":46819,"RHEA_ID":55218,"compounds":"diphosphate + rhizathalene A => all-trans-geranylgeranyl diphosphate"}
{"X":46820,"RHEA_ID":45236,"compounds":"(25R)-3beta-hydroxy-5-cholesten-26-al + H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta-hydroxy-5-cholestenoate + H2O + 2 oxidized [adrenodoxin]"}
{"X":46821,"RHEA_ID":45237,"compounds":"(25R)-3beta-hydroxy-5-cholesten-26-al + H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta-hydroxy-5-cholestenoate + H2O + 2 oxidized [adrenodoxin]"}
{"X":46822,"RHEA_ID":55221,"DIRECTION":"LR","MASTER_ID":55220,"metacyc":"RXN-13188","compounds":"4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 => 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate + 6 [Fe(III)-cytochrome b5] + 4 H2O"}
{"X":46823,"RHEA_ID":48538,"compounds":"1-beta-D-galactosyl-dodecanoyl-sn-glycerol + dodecanoate + H(+) => 1-beta-D-galactosyl-2,3-didodecanoyl-sn-glycerol + H2O"}
{"X":46824,"RHEA_ID":45240,"DIRECTION":"UN","MASTER_ID":45240,"ec":"5.3.3.21","compounds":"a (3E,5Z)-dienoyl-CoA = a (2E,4E)-(5,6-saturated)-dienoyl-CoA"}
{"X":46825,"RHEA_ID":45241,"DIRECTION":"LR","MASTER_ID":45240,"metacyc":"RXN-12520","compounds":"a (3E,5Z)-dienoyl-CoA => a (2E,4E)-(5,6-saturated)-dienoyl-CoA"}
{"X":46826,"RHEA_ID":55225,"DIRECTION":"LR","MASTER_ID":55224,"metacyc":"1.14.13.72-RXN","compounds":"4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 4beta-hydroxymethyl-4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":46827,"RHEA_ID":48542,"compounds":"dodecanoate + dodecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+) => 1,2-didodecanoyl-3-beta-D-galactosyl-sn-glycerol + H2O"}
{"X":46828,"RHEA_ID":45244,"compounds":"(3E,5Z)-octadienoyl-CoA = (2E,4E)-octadienoyl-CoA"}
{"X":46829,"RHEA_ID":45245,"compounds":"(3E,5Z)-octadienoyl-CoA => (2E,4E)-octadienoyl-CoA"}
{"X":46830,"RHEA_ID":55229,"DIRECTION":"LR","MASTER_ID":55228,"metacyc":"RXN-6271","compounds":"4beta-hydroxymethyl-4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":46831,"RHEA_ID":55230,"compounds":"3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 [Fe(III)-cytochrome b5] + 2 H2O => 4beta-hydroxymethyl-4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}
{"X":46832,"RHEA_ID":45248,"compounds":"butanoate(out) = butanoate(in)"}
{"X":46833,"RHEA_ID":45249,"compounds":"butanoate(out) => butanoate(in)"}
{"X":46834,"RHEA_ID":55233,"DIRECTION":"LR","MASTER_ID":55232,"metacyc":"RXN-6269","compounds":"3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 [Fe(II)-cytochrome b5] + H(+) + O2 => 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate + 2 [Fe(III)-cytochrome b561] + H2O"}
{"X":46835,"RHEA_ID":51919,"compounds":"(2S)-2-amino-3-butenoate + H2O <=> 2-oxobutanoate + NH4(+)"}
{"X":46836,"RHEA_ID":45252,"compounds":"tetradecanoate(out) = tetradecanoate(in)"}
{"X":46837,"RHEA_ID":45253,"compounds":"tetradecanoate(out) => tetradecanoate(in)"}
{"X":46838,"RHEA_ID":45254,"compounds":"tetradecanoate(in) => tetradecanoate(out)"}
{"X":46839,"RHEA_ID":45255,"compounds":"tetradecanoate(out) <=> tetradecanoate(in)"}
{"X":46840,"RHEA_ID":45256,"compounds":"hexadecanoate(out) = hexadecanoate(in)"}
{"X":46841,"RHEA_ID":45257,"compounds":"hexadecanoate(out) => hexadecanoate(in)"}
{"X":46842,"RHEA_ID":55241,"compounds":"1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H2O => (9Z)-octadecenoate + 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H(+)"}
{"X":46843,"RHEA_ID":55242,"compounds":"(9Z)-octadecenoate + 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H(+) => 1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H2O"}
{"X":46844,"RHEA_ID":45260,"compounds":"tetracosanoate(out) = tetracosanoate(in)"}
{"X":46845,"RHEA_ID":45261,"compounds":"tetracosanoate(out) => tetracosanoate(in)"}
{"X":46846,"RHEA_ID":55245,"DIRECTION":"LR","MASTER_ID":55244,"metacyc":"RXN-13712","compounds":"4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}
{"X":46847,"RHEA_ID":55246,"compounds":"4alpha-carboxyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O => 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2"}
{"X":46848,"RHEA_ID":45264,"compounds":"(9Z,12Z)-octadecadienoate(out) = (9Z,12Z)-octadecadienoate(in)"}
{"X":46849,"RHEA_ID":45265,"compounds":"(9Z,12Z)-octadecadienoate(out) => (9Z,12Z)-octadecadienoate(in)"}
{"X":46850,"RHEA_ID":55249,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine => 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":46851,"RHEA_ID":58592,"compounds":"1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH = 1-hexadecanoyl-2-(9-hydroxynonanoyl)-sn-glycero-3-phosphocholine + NADP(+)"}
{"X":46852,"RHEA_ID":45268,"compounds":"4'-hydroxyechinenone + AH2 + O2 = 4',4'-dihydroxyechinenone + A + H2O"}
{"X":46853,"RHEA_ID":45269,"DIRECTION":"LR","MASTER_ID":45268,"metacyc":"RXN-18965","compounds":"4'-hydroxyechinenone + AH2 + O2 => 4',4'-dihydroxyechinenone + A + H2O"}
{"X":46854,"RHEA_ID":45270,"compounds":"4',4'-dihydroxyechinenone + A + H2O => 4'-hydroxyechinenone + AH2 + O2"}
{"X":46855,"RHEA_ID":45271,"compounds":"4'-hydroxyechinenone + AH2 + O2 <=> 4',4'-dihydroxyechinenone + A + H2O"}
{"X":46856,"RHEA_ID":45272,"compounds":"12-phosphooxy-(9Z)-octadecenoate + H2O = 12-hydroxy-(9Z)-octadecenoate + phosphate"}
{"X":46857,"RHEA_ID":45273,"compounds":"12-phosphooxy-(9Z)-octadecenoate + H2O => 12-hydroxy-(9Z)-octadecenoate + phosphate"}
{"X":46858,"RHEA_ID":55257,"compounds":"1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":46859,"RHEA_ID":58604,"compounds":"FAD + 2 H(+) + NADH + O2 = FADH2-C4alpha-hydroperoxide + NAD(+)"}
{"X":46860,"RHEA_ID":45276,"compounds":"12-phosphooxy-(9E)-octadecenoate + H2O = 12-hydroxy-(9E)-octadecenoate + phosphate"}
{"X":46861,"RHEA_ID":45277,"compounds":"12-phosphooxy-(9E)-octadecenoate + H2O => 12-hydroxy-(9E)-octadecenoate + phosphate"}
{"X":46862,"RHEA_ID":45278,"compounds":"12-hydroxy-(9E)-octadecenoate + phosphate => 12-phosphooxy-(9E)-octadecenoate + H2O"}
{"X":46863,"RHEA_ID":55262,"compounds":"2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 2 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":46864,"RHEA_ID":45280,"compounds":"12-(phosphooxy)octadecanoate + H2O = 12-hydroxyoctadecanoate + phosphate"}
{"X":46865,"RHEA_ID":45281,"compounds":"12-(phosphooxy)octadecanoate + H2O => 12-hydroxyoctadecanoate + phosphate"}
{"X":46866,"RHEA_ID":45282,"compounds":"12-hydroxyoctadecanoate + phosphate => 12-(phosphooxy)octadecanoate + H2O"}
{"X":46867,"RHEA_ID":55266,"compounds":"di-(9Z,12Z)-octadecadienoylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine => 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine"}
{"X":46868,"RHEA_ID":45284,"compounds":"eicosanoyl-CoA + sphing-4-enine = CoA + H(+) + N-eicosanoyl-sphing-4-enine"}
{"X":46869,"RHEA_ID":45285,"compounds":"eicosanoyl-CoA + sphing-4-enine => CoA + H(+) + N-eicosanoyl-sphing-4-enine"}
{"X":46870,"RHEA_ID":45286,"compounds":"CoA + H(+) + N-eicosanoyl-sphing-4-enine => eicosanoyl-CoA + sphing-4-enine"}
{"X":46871,"RHEA_ID":55270,"compounds":"(R)-glycerate + alpha-D-glucose 1-phosphate => (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate"}
{"X":46872,"RHEA_ID":45288,"compounds":"2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 2 O2 = 2-glyceryl-prostaglandin G2"}
{"X":46873,"RHEA_ID":48588,"compounds":"2 H2O + 2 leukotriene A4 + O2 = 2 lipoxin B4"}
{"X":46874,"RHEA_ID":55273,"compounds":"11-cis-retinol + tetradecanoyl-CoA => 11-cis-retinyl tetradecanoate + CoA"}
{"X":46875,"RHEA_ID":55274,"compounds":"11-cis-retinyl tetradecanoate + CoA => 11-cis-retinol + tetradecanoyl-CoA"}
{"X":46876,"RHEA_ID":45292,"compounds":"2-glyceryl-prostaglandin G2 + AH2 = 2-glyceryl-prostaglandin H2 + A + H2O"}
{"X":46877,"RHEA_ID":45293,"compounds":"2-glyceryl-prostaglandin G2 + AH2 => 2-glyceryl-prostaglandin H2 + A + H2O"}
{"X":46878,"RHEA_ID":55277,"compounds":"9-cis-retinol + tetradecanoyl-CoA => 9-cis-retinyl tetradecanoate + CoA"}
{"X":46879,"RHEA_ID":55278,"compounds":"9-cis-retinyl tetradecanoate + CoA => 9-cis-retinol + tetradecanoyl-CoA"}
{"X":46880,"RHEA_ID":45296,"compounds":"H2O + sphingosylphosphocholine = a sphingoid base + H(+) + phosphocholine"}
{"X":46881,"RHEA_ID":45297,"compounds":"H2O + sphingosylphosphocholine => a sphingoid base + H(+) + phosphocholine"}
{"X":46882,"RHEA_ID":55281,"compounds":"13-cis-retinol + tetradecanoyl-CoA => 13-cis-retinyl tetradecanoate + CoA"}
{"X":46883,"RHEA_ID":55282,"compounds":"13-cis-retinyl tetradecanoate + CoA => 13-cis-retinol + tetradecanoyl-CoA"}
{"X":46884,"RHEA_ID":45300,"compounds":"an N-(acyl)-sphingosylphosphocholine + H2O = H(+) + N-acyl-sphingoid base + phosphocholine"}
{"X":46885,"RHEA_ID":45301,"compounds":"an N-(acyl)-sphingosylphosphocholine + H2O => H(+) + N-acyl-sphingoid base + phosphocholine"}
{"X":46886,"RHEA_ID":55285,"compounds":"all-trans-retinol + tetradecanoyl-CoA => all-trans-retinyl tetradecanoate + CoA"}
{"X":46887,"RHEA_ID":55286,"compounds":"all-trans-retinyl tetradecanoate + CoA => all-trans-retinol + tetradecanoyl-CoA"}
{"X":46888,"RHEA_ID":45304,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycerol + H(+) + phosphocholine"}
{"X":46889,"RHEA_ID":45305,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1,2-dihexadecanoyl-sn-glycerol + H(+) + phosphocholine"}
{"X":46890,"RHEA_ID":55289,"compounds":"tetradecan-1-ol + tetradecanoyl-CoA => CoA + tetradecanyl tetradecanoate"}
{"X":46891,"RHEA_ID":55290,"compounds":"CoA + tetradecanyl tetradecanoate => tetradecan-1-ol + tetradecanoyl-CoA"}
{"X":46892,"RHEA_ID":45308,"compounds":"H(+) + NADPH + prostaglandin D2-ethanolamide = 11beta-prostaglandin F2-ethanolamide + NADP(+)"}
{"X":46893,"RHEA_ID":45309,"compounds":"H(+) + NADPH + prostaglandin D2-ethanolamide => 11beta-prostaglandin F2-ethanolamide + NADP(+)"}
{"X":46894,"RHEA_ID":55293,"DIRECTION":"LR","MASTER_ID":55292,"metacyc":"RXN-13326","compounds":"pseudouridine(54) in tRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylpseudouridine(54) in tRNA + S-adenosyl-L-homocysteine"}
{"X":46895,"RHEA_ID":55294,"compounds":"H(+) + N(1)-methylpseudouridine(54) in tRNA + S-adenosyl-L-homocysteine => pseudouridine(54) in tRNA + S-adenosyl-L-methionine"}
{"X":46896,"RHEA_ID":45312,"compounds":"NADP(+) + prostaglandin F2alpha = H(+) + NADPH + prostaglandin H2"}
{"X":46897,"RHEA_ID":45313,"compounds":"NADP(+) + prostaglandin F2alpha => H(+) + NADPH + prostaglandin H2"}
{"X":46898,"RHEA_ID":55297,"compounds":"13-cis-retinol + hexadecanoyl-CoA => 13-cis-retinyl hexadecanoate + CoA"}
{"X":46899,"RHEA_ID":45315,"compounds":"NADP(+) + prostaglandin F2alpha <=> H(+) + NADPH + prostaglandin H2"}
{"X":46900,"RHEA_ID":55299,"compounds":"13-cis-retinol + hexadecanoyl-CoA <=> 13-cis-retinyl hexadecanoate + CoA"}
{"X":46901,"RHEA_ID":45317,"DIRECTION":"LR","MASTER_ID":45316,"reactome":"R-HSA-2161614.2","compounds":"H(+) + NADPH + prostaglandin D2 => 11beta-prostaglandin F2 + NADP(+)"}
{"X":46902,"RHEA_ID":55301,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":46903,"RHEA_ID":45319,"compounds":"H(+) + NADPH + prostaglandin D2 <=> 11beta-prostaglandin F2 + NADP(+)"}
{"X":46904,"RHEA_ID":45320,"compounds":"H2O + N-(15Z-tetracosenoyl)sphing-4-enine-1-phosphocholine = H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine + phosphocholine"}
{"X":46905,"RHEA_ID":45321,"compounds":"H2O + N-(15Z-tetracosenoyl)sphing-4-enine-1-phosphocholine => H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine + phosphocholine"}
{"X":46906,"RHEA_ID":55305,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate => 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA"}
{"X":46907,"RHEA_ID":45323,"compounds":"H2O + N-(15Z-tetracosenoyl)sphing-4-enine-1-phosphocholine <=> H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine + phosphocholine"}
{"X":46908,"RHEA_ID":45324,"compounds":"H2O + N-(tetracosanoyl)-sphing-4-enine-1-phosphocholine = H(+) + N-(tetracosanoyl)-sphing-4-enine + phosphocholine"}
{"X":46909,"RHEA_ID":45325,"compounds":"H2O + N-(tetracosanoyl)-sphing-4-enine-1-phosphocholine => H(+) + N-(tetracosanoyl)-sphing-4-enine + phosphocholine"}
{"X":46910,"RHEA_ID":55309,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":46911,"RHEA_ID":45327,"compounds":"H2O + N-(tetracosanoyl)-sphing-4-enine-1-phosphocholine <=> H(+) + N-(tetracosanoyl)-sphing-4-enine + phosphocholine"}
{"X":46912,"RHEA_ID":55311,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate <=> 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":46913,"RHEA_ID":45329,"compounds":"7,8-dihydroneopterin => 7,8-dihydromonapterin"}
{"X":46914,"RHEA_ID":55313,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":46915,"RHEA_ID":55314,"compounds":"1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate"}
{"X":46916,"RHEA_ID":55315,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":46917,"RHEA_ID":45333,"compounds":"7,8-dihydroneopterin + O2 => 7,8-dihydroxanthopterin + formate + glycolaldehyde + H(+)"}
{"X":46918,"RHEA_ID":55317,"compounds":"3 H2O + hydrogen sulfide + 3 NAD(+) => 4 H(+) + 3 NADH + sulfite"}
{"X":46919,"RHEA_ID":55318,"compounds":"4 H(+) + 3 NADH + sulfite => 3 H2O + hydrogen sulfide + 3 NAD(+)"}
{"X":46920,"RHEA_ID":45337,"compounds":"(9Z)-hexadecenoyl-CoA + [Wnt protein]-L-serine => [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + CoA"}
{"X":46921,"RHEA_ID":55321,"compounds":"1,2-diheptanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] => 2-heptanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl heptanoate + apo--[retinol-binding protein]"}
{"X":46922,"RHEA_ID":55322,"compounds":"2-heptanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl heptanoate + apo--[retinol-binding protein] => 1,2-diheptanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein]"}
{"X":46923,"RHEA_ID":55323,"compounds":"1,2-diheptanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] <=> 2-heptanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl heptanoate + apo--[retinol-binding protein]"}
{"X":46924,"RHEA_ID":45341,"compounds":"[Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + H2O => (9Z)-hexadecenoate + [Wnt protein]-L-serine + H(+)"}
{"X":46925,"RHEA_ID":55325,"compounds":"11-cis-retinol + hexadecanoyl-CoA => 11-cis-retinyl hexadecanoate + CoA"}
{"X":46926,"RHEA_ID":55326,"compounds":"11-cis-retinyl hexadecanoate + CoA => 11-cis-retinol + hexadecanoyl-CoA"}
{"X":46927,"RHEA_ID":55327,"compounds":"11-cis-retinol + hexadecanoyl-CoA <=> 11-cis-retinyl hexadecanoate + CoA"}
{"X":46928,"RHEA_ID":45345,"compounds":"globoside NOR1 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => globoside NORint (d18:1(4E)) + H(+) + UDP"}
{"X":46929,"RHEA_ID":55332,"DIRECTION":"UN","MASTER_ID":55332,"ec":"2.1.1.267","compounds":"a 3'-hydroxyflavone + S-adenosyl-L-methionine = a 3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine"}
{"X":46930,"RHEA_ID":45347,"compounds":"globoside NOR1 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> globoside NORint (d18:1(4E)) + H(+) + UDP"}
{"X":46931,"RHEA_ID":45348,"compounds":"H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphing-4-enine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + sphing-4-enine"}
{"X":46932,"RHEA_ID":45349,"compounds":"H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphing-4-enine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + sphing-4-enine"}
{"X":46933,"RHEA_ID":55336,"DIRECTION":"UN","MASTER_ID":55336,"ec":"2.1.1.267","compounds":"a 5'-hydroxy-3'-methoxyflavone + S-adenosyl-L-methionine = a 3',5'-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine"}
{"X":46934,"RHEA_ID":55337,"DIRECTION":"LR","MASTER_ID":55336,"metacyc":"RXN-13956","compounds":"a 5'-hydroxy-3'-methoxyflavone + S-adenosyl-L-methionine => a 3',5'-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine"}
{"X":46935,"RHEA_ID":55338,"compounds":"a 3',5'-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine => a 5'-hydroxy-3'-methoxyflavone + S-adenosyl-L-methionine"}
{"X":46936,"RHEA_ID":45353,"compounds":"9,10-epoxyoctadecanoate + H2O => 9,10-dihydroxyoctadecanoate"}
{"X":46937,"RHEA_ID":55340,"compounds":"(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol = 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol + CoA"}
{"X":46938,"RHEA_ID":55341,"compounds":"(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol => 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol + CoA"}
{"X":46939,"RHEA_ID":55342,"compounds":"1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol"}
{"X":46940,"RHEA_ID":45357,"compounds":"H2O + N-(11Z-eicosenoyl)-sphing-4-enine => (11Z)-eicosenoate + sphing-4-enine"}
{"X":46941,"RHEA_ID":55344,"compounds":"(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol = 1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerol + CoA"}
{"X":46942,"RHEA_ID":55345,"compounds":"(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol => 1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerol + CoA"}
{"X":46943,"RHEA_ID":55346,"compounds":"1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol"}
{"X":46944,"RHEA_ID":45361,"compounds":"H2O + N-(11Z-eicosenoyl)-sphinganine => (11Z)-eicosenoate + sphinganine"}
{"X":46945,"RHEA_ID":55348,"compounds":"all-trans-retinol = 9-cis-retinol"}
{"X":46946,"RHEA_ID":55349,"compounds":"all-trans-retinol => 9-cis-retinol"}
{"X":46947,"RHEA_ID":45364,"compounds":"H2O + N-(11Z-eicosenoyl)-4-hydroxysphinganine = (11Z)-eicosenoate + 4-hydroxysphinganine"}
{"X":46948,"RHEA_ID":55351,"compounds":"all-trans-retinol <=> 9-cis-retinol"}
{"X":46949,"RHEA_ID":55352,"compounds":"all-trans-retinol = 13-cis-retinol"}
{"X":46950,"RHEA_ID":55353,"compounds":"all-trans-retinol => 13-cis-retinol"}
{"X":46951,"RHEA_ID":45368,"compounds":"H2O + N-(9Z-octadecenoyl)-4-hydroxysphinganine = (9Z)-octadecenoate + 4-hydroxysphinganine"}
{"X":46952,"RHEA_ID":55355,"compounds":"all-trans-retinol <=> 13-cis-retinol"}
{"X":46953,"RHEA_ID":55356,"compounds":"11-cis-retinol = 13-cis-retinol"}
{"X":46954,"RHEA_ID":55357,"compounds":"11-cis-retinol => 13-cis-retinol"}
{"X":46955,"RHEA_ID":45372,"compounds":"H2O + N-(9Z-octadecenoyl)-sphinganine = (9Z)-octadecenoate + sphinganine"}
{"X":46956,"RHEA_ID":55359,"compounds":"11-cis-retinol <=> 13-cis-retinol"}
{"X":46957,"RHEA_ID":55360,"compounds":"11-cis-retinol = 9-cis-retinol"}
{"X":46958,"RHEA_ID":55361,"compounds":"11-cis-retinol => 9-cis-retinol"}
{"X":46959,"RHEA_ID":45376,"compounds":"H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphinganine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + sphinganine"}
{"X":46960,"RHEA_ID":55363,"compounds":"11-cis-retinol <=> 9-cis-retinol"}
{"X":46961,"RHEA_ID":55364,"compounds":"(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate = all-trans-nonaprenyl diphosphate + 6 diphosphate"}
{"X":46962,"RHEA_ID":55365,"compounds":"(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate => all-trans-nonaprenyl diphosphate + 6 diphosphate"}
{"X":46963,"RHEA_ID":45380,"compounds":"H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4-hydroxysphinganine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 4-hydroxysphinganine"}
{"X":46964,"RHEA_ID":55367,"compounds":"(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate <=> all-trans-nonaprenyl diphosphate + 6 diphosphate"}
{"X":46965,"RHEA_ID":55368,"DIRECTION":"UN","MASTER_ID":55368,"ec":"1.14.13.239","compounds":"(R)-carnitine + H(+) + NADPH + O2 = (3R)-3-hydroxy-4-oxobutanoate + H2O + NADP(+) + trimethylamine"}
{"X":46966,"RHEA_ID":55369,"DIRECTION":"LR","MASTER_ID":55368,"metacyc":"RXN-5921","compounds":"(R)-carnitine + H(+) + NADPH + O2 => (3R)-3-hydroxy-4-oxobutanoate + H2O + NADP(+) + trimethylamine"}
{"X":46967,"RHEA_ID":45384,"compounds":"H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":46968,"RHEA_ID":58714,"compounds":"H(+) + H2O + NAD(+) + rifampicin para-naphthoquinone carboxamide => NADH + O2 + rifampicin"}
{"X":46969,"RHEA_ID":55376,"compounds":"2 a quinol + O2 = 2 a quinone + 2 H2O"}
{"X":46970,"RHEA_ID":55377,"compounds":"2 a quinol + O2 => 2 a quinone + 2 H2O"}
{"X":46971,"RHEA_ID":45388,"compounds":"H2O + N-octadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-octadecanoyl-sn-glycero-3-phospho-ethanolamine"}
{"X":46972,"RHEA_ID":48688,"DIRECTION":"UN","MASTER_ID":48688,"ec":"3.4.17.13","compounds":"H2O + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanine = D-alanine + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl"}
{"X":46973,"RHEA_ID":45390,"compounds":"(9Z)-octadecenoate + H(+) + N-octadecanoyl-sn-glycero-3-phospho-ethanolamine => H2O + N-octadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":46974,"RHEA_ID":45391,"compounds":"H2O + N-octadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z)-octadecenoate + H(+) + N-octadecanoyl-sn-glycero-3-phospho-ethanolamine"}
{"X":46975,"RHEA_ID":45392,"compounds":"H2O + N-eicosanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-eicosanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":46976,"RHEA_ID":55383,"DIRECTION":"BI","MASTER_ID":55380,"metacyc":"RXN-17408","compounds":"a 3alpha-hydroxy bile acid CoA + NAD(+) <=> a 3-oxo bile acid CoA + H(+) + NADH"}
{"X":46977,"RHEA_ID":45394,"compounds":"(9Z)-octadecenoate + H(+) + N-eicosanoyl-sn-glycero-3-phosphoethanolamine => H2O + N-eicosanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":46978,"RHEA_ID":45395,"compounds":"H2O + N-eicosanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z)-octadecenoate + H(+) + N-eicosanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":46979,"RHEA_ID":45396,"compounds":"H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":46980,"RHEA_ID":45397,"compounds":"H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => (9Z)-octadecenoate + H(+) + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":46981,"RHEA_ID":55388,"DIRECTION":"UN","MASTER_ID":55388,"ec":"1.1.99.41","compounds":"(3R)-3-hydroxy-2,3-dihydrotabersonine + A = (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + AH2"}
{"X":46982,"RHEA_ID":45399,"compounds":"H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z)-octadecenoate + H(+) + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":46983,"RHEA_ID":45400,"compounds":"H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":46984,"RHEA_ID":45401,"compounds":"H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => (9Z)-octadecenoate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":46985,"RHEA_ID":55392,"compounds":"adenosine in mRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine in mRNA + S-adenosyl-L-homocysteine"}
{"X":46986,"RHEA_ID":55393,"compounds":"adenosine in mRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyladenosine in mRNA + S-adenosyl-L-homocysteine"}
{"X":46987,"RHEA_ID":45404,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate = 1-O-(9Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":46988,"RHEA_ID":55395,"compounds":"adenosine in mRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyladenosine in mRNA + S-adenosyl-L-homocysteine"}
{"X":46989,"RHEA_ID":55396,"DIRECTION":"UN","MASTER_ID":55396,"ec":"1.14.13.239","compounds":"(R)-carnitine + H(+) + NADH + O2 = (3R)-3-hydroxy-4-oxobutanoate + H2O + NAD(+) + trimethylamine"}
{"X":46990,"RHEA_ID":55397,"DIRECTION":"LR","MASTER_ID":55396,"metacyc":"RXN-5921","compounds":"(R)-carnitine + H(+) + NADH + O2 => (3R)-3-hydroxy-4-oxobutanoate + H2O + NAD(+) + trimethylamine"}
{"X":46991,"RHEA_ID":45408,"compounds":"(2E)-dodecenoyl-CoA + H(+) + NADH = dodecanoyl-CoA + NAD(+)"}
{"X":46992,"RHEA_ID":58738,"compounds":"5-methyl-UMP + diphosphate + H(+) => 5-methyl-UTP + H2O"}
{"X":46993,"RHEA_ID":45410,"compounds":"dodecanoyl-CoA + NAD(+) => (2E)-dodecenoyl-CoA + H(+) + NADH"}
{"X":46994,"RHEA_ID":55401,"DIRECTION":"LR","MASTER_ID":55400,"metacyc":"RXN-19021","compounds":"7-cyano-7-carbaguanosine(15) in tRNA + NH4(+) => archaeosine(15) in tRNA"}
{"X":46995,"RHEA_ID":45412,"compounds":"H2O + prostaglandin D2-1-glycerol ester = glycerol + H(+) + prostaglandin D2"}
{"X":46996,"RHEA_ID":55403,"compounds":"7-cyano-7-carbaguanosine(15) in tRNA + NH4(+) <=> archaeosine(15) in tRNA"}
{"X":46997,"RHEA_ID":55404,"compounds":"[phosphate](n) + UTP = [phosphate](n+1) + UDP"}
{"X":46998,"RHEA_ID":55405,"compounds":"[phosphate](n) + UTP => [phosphate](n+1) + UDP"}
{"X":46999,"RHEA_ID":45416,"compounds":"11-oxo-5Z,9,12E,14E-prostatetraenoate + H2O = 15-deoxy-Delta(12,14)-prostaglandin J2 + glycerol + H(+)"}
{"X":47000,"RHEA_ID":55407,"compounds":"[phosphate](n) + UTP <=> [phosphate](n+1) + UDP"}
{"X":47001,"RHEA_ID":55408,"compounds":"[phosphate](n) + CTP = [phosphate](n+1) + CDP"}
{"X":47002,"RHEA_ID":45419,"compounds":"11-oxo-5Z,9,12E,14E-prostatetraenoate + H2O <=> 15-deoxy-Delta(12,14)-prostaglandin J2 + glycerol + H(+)"}
{"X":47003,"RHEA_ID":45420,"compounds":"H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine = a fatty acid + H(+) + N-acyl-sn-glycero-3-phosphoethanolamine"}
{"X":47004,"RHEA_ID":55411,"compounds":"[phosphate](n) + CTP <=> [phosphate](n+1) + CDP"}
{"X":47005,"RHEA_ID":55412,"compounds":"[phosphate](n) + GTP = [phosphate](n+1) + GDP"}
{"X":47006,"RHEA_ID":55413,"compounds":"[phosphate](n) + GTP => [phosphate](n+1) + GDP"}
{"X":47007,"RHEA_ID":45424,"compounds":"H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":47008,"RHEA_ID":55415,"compounds":"[phosphate](n) + GTP <=> [phosphate](n+1) + GDP"}
{"X":47009,"RHEA_ID":55416,"DIRECTION":"UN","MASTER_ID":55416,"ec":"2.4.1.170","compounds":"biochanin A + UDP-alpha-D-glucose = biochanin A 7-O-beta-D-glucoside + H(+) + UDP"}
{"X":47010,"RHEA_ID":45427,"compounds":"H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z)-octadecenoate + H(+) + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":47011,"RHEA_ID":45428,"compounds":"H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine = H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + sn-glycerol 3-phosphate"}
{"X":47012,"RHEA_ID":45429,"compounds":"H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine => H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + sn-glycerol 3-phosphate"}
{"X":47013,"RHEA_ID":45430,"compounds":"H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + sn-glycerol 3-phosphate => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":47014,"RHEA_ID":48730,"DIRECTION":"RL","MASTER_ID":48728,"metacyc":"RXN-15030","compounds":"4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H(+) + NADH => 3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NAD(+)"}
{"X":47015,"RHEA_ID":45432,"compounds":"H2O + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = H(+) + N-(9Z-octadecenoyl) ethanolamine + sn-glycerol 3-phosphate"}
{"X":47016,"RHEA_ID":45433,"compounds":"H2O + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => H(+) + N-(9Z-octadecenoyl) ethanolamine + sn-glycerol 3-phosphate"}
{"X":47017,"RHEA_ID":48733,"DIRECTION":"LR","MASTER_ID":48732,"metacyc":"RXN-14567","compounds":"[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + H2O => [CysO sulfur-carrier protein]-C-terminal Gly-Gly + H(+) + L-cysteine"}
{"X":47018,"RHEA_ID":48734,"compounds":"[CysO sulfur-carrier protein]-C-terminal Gly-Gly + H(+) + L-cysteine => [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + H2O"}
{"X":47019,"RHEA_ID":45436,"compounds":"H2O + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine = H(+) + N-hexadecanoylethanolamine + sn-glycerol 3-phosphate"}
{"X":47020,"RHEA_ID":45437,"compounds":"H2O + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine => H(+) + N-hexadecanoylethanolamine + sn-glycerol 3-phosphate"}
{"X":47021,"RHEA_ID":45438,"compounds":"H(+) + N-hexadecanoylethanolamine + sn-glycerol 3-phosphate => H2O + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":47022,"RHEA_ID":48738,"compounds":"(18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":47023,"RHEA_ID":45440,"compounds":"H2O + N-eicosanoyl-sn-glycero-3-phosphoethanolamine = H(+) + N-eicosanoyl ethanolamine + sn-glycerol 3-phosphate"}
{"X":47024,"RHEA_ID":45441,"compounds":"H2O + N-eicosanoyl-sn-glycero-3-phosphoethanolamine => H(+) + N-eicosanoyl ethanolamine + sn-glycerol 3-phosphate"}
{"X":47025,"RHEA_ID":45442,"compounds":"H(+) + N-eicosanoyl ethanolamine + sn-glycerol 3-phosphate => H2O + N-eicosanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":47026,"RHEA_ID":55433,"DIRECTION":"LR","MASTER_ID":55432,"metacyc":"RXN-18881","compounds":"11-hydroxyferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => carnosate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}
{"X":47027,"RHEA_ID":45444,"compounds":"H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-sn-glycero-3-phosphoethanolamine = H(+) + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl ethanolamine + sn-glycerol 3-phosphate"}
{"X":47028,"RHEA_ID":45445,"compounds":"H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-sn-glycero-3-phosphoethanolamine => H(+) + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl ethanolamine + sn-glycerol 3-phosphate"}
{"X":47029,"RHEA_ID":45446,"compounds":"H(+) + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl ethanolamine + sn-glycerol 3-phosphate => H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-sn-glycero-3-phosphoethanolamine"}
{"X":47030,"RHEA_ID":48746,"compounds":"(-)-deoxypodophyllotoxin + CO2 + H2O + succinate => (-)-yatein + 2-oxoglutarate + O2"}
{"X":47031,"RHEA_ID":45448,"compounds":"H2O + N-(dodecanoyl)-sphinganine = dodecanoate + sphinganine"}
{"X":47032,"RHEA_ID":45449,"compounds":"H2O + N-(dodecanoyl)-sphinganine => dodecanoate + sphinganine"}
{"X":47033,"RHEA_ID":45450,"compounds":"dodecanoate + sphinganine => H2O + N-(dodecanoyl)-sphinganine"}
{"X":47034,"RHEA_ID":45451,"compounds":"H2O + N-(dodecanoyl)-sphinganine <=> dodecanoate + sphinganine"}
{"X":47035,"RHEA_ID":55442,"compounds":"H(+) + H2O + maniladiol + oxidized [NADPH--hemoprotein reductase] => beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":47036,"RHEA_ID":45453,"compounds":"H2O + N-tetradecanoylethanolamine => ethanolamine + tetradecanoate"}
{"X":47037,"RHEA_ID":45454,"compounds":"ethanolamine + tetradecanoate => H2O + N-tetradecanoylethanolamine"}
{"X":47038,"RHEA_ID":45455,"compounds":"H2O + N-tetradecanoylethanolamine <=> ethanolamine + tetradecanoate"}
{"X":47039,"RHEA_ID":55446,"compounds":"cochalate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + oleanolate + reduced [NADPH--hemoprotein reductase]"}
{"X":47040,"RHEA_ID":45457,"compounds":"H2O + N-dodecanoylethanolamine => dodecanoate + ethanolamine"}
{"X":47041,"RHEA_ID":45458,"compounds":"dodecanoate + ethanolamine => H2O + N-dodecanoylethanolamine"}
{"X":47042,"RHEA_ID":45459,"compounds":"H2O + N-dodecanoylethanolamine <=> dodecanoate + ethanolamine"}
{"X":47043,"RHEA_ID":55450,"compounds":"a 3',5'-dihydroxyflavanone + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => a 3',5'-unsubstituted flavanone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}
{"X":47044,"RHEA_ID":45461,"compounds":"H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a fatty acid + H(+) + N,1-diacyl-sn-glycero-3-phosphoethanolamine"}
{"X":47045,"RHEA_ID":45462,"compounds":"a fatty acid + H(+) + N,1-diacyl-sn-glycero-3-phosphoethanolamine => H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine"}
{"X":47046,"RHEA_ID":55453,"DIRECTION":"LR","MASTER_ID":55452,"metacyc":"RXN-18884","compounds":"beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => daturadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47047,"RHEA_ID":55454,"compounds":"daturadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":47048,"RHEA_ID":45465,"DIRECTION":"LR","MASTER_ID":45464,"metacyc":"RXN-8372","compounds":"2 [Fe(II)-cytochrome b5] + eicosanoyl-CoA + 2 H(+) + O2 => (5Z)-eicosenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":47049,"RHEA_ID":45466,"compounds":"(5Z)-eicosenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => 2 [Fe(II)-cytochrome b5] + eicosanoyl-CoA + 2 H(+) + O2"}
{"X":47050,"RHEA_ID":55457,"DIRECTION":"LR","MASTER_ID":55456,"metacyc":"RXN-18901","compounds":"ferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + sugiol"}
{"X":47051,"RHEA_ID":55458,"compounds":"2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + sugiol => ferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}
{"X":47052,"RHEA_ID":45469,"DIRECTION":"LR","MASTER_ID":45468,"ecocyc":"RXN-16281","metacyc":"RXN-16281","compounds":"alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + di-trans,octa-cis-undecaprenyl diphosphate => (Kdo)2-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate"}
{"X":47053,"RHEA_ID":45470,"compounds":"(Kdo)2-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + di-trans,octa-cis-undecaprenyl diphosphate"}
{"X":47054,"RHEA_ID":48770,"compounds":"ADP + D-erythrulose 4-phosphate + H(+) => ATP + D-erythrulose"}
{"X":47055,"RHEA_ID":45472,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-glycerol + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-glycerol + H(+) + hexadecanoate"}
{"X":47056,"RHEA_ID":45473,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-glycerol + H2O => 1-hexadecanoyl-sn-glycero-3-phospho-glycerol + H(+) + hexadecanoate"}
{"X":47057,"RHEA_ID":45474,"compounds":"1-hexadecanoyl-sn-glycero-3-phospho-glycerol + H(+) + hexadecanoate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-glycerol + H2O"}
{"X":47058,"RHEA_ID":45475,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-glycerol + H2O <=> 1-hexadecanoyl-sn-glycero-3-phospho-glycerol + H(+) + hexadecanoate"}
{"X":47059,"RHEA_ID":45476,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":47060,"RHEA_ID":45477,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":47061,"RHEA_ID":45478,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine"}
{"X":47062,"RHEA_ID":55469,"DIRECTION":"LR","MASTER_ID":55468,"metacyc":"RXN-18904","compounds":"11-hydroxyferruginol + O2 + reduced [NADPH--hemoprotein reductase] => 11,20-dihydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47063,"RHEA_ID":45480,"compounds":"gamma-hexachlorocyclohexane = (3R,4S,5S,6R)-pentachlorocyclohexene + chloride + H(+)"}
{"X":47064,"RHEA_ID":48780,"DIRECTION":"UN","MASTER_ID":48780,"ec":"2.7.1.209","compounds":"ATP + L-erythrulose = ADP + H(+) + L-erythrulose 1-phosphate"}
{"X":47065,"RHEA_ID":55472,"DIRECTION":"UN","MASTER_ID":55472,"ec":"1.14.14.68","compounds":"9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase] = 9beta-pimara-7,15-diene-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47066,"RHEA_ID":58816,"DIRECTION":"UN","MASTER_ID":58816,"ec":"6.3.2.53","compounds":"ATP + L-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate"}
{"X":47067,"RHEA_ID":55474,"compounds":"9beta-pimara-7,15-diene-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":47068,"RHEA_ID":45485,"DIRECTION":"LR","MASTER_ID":45484,"macie":"M0215","metacyc":"RXN-6161","compounds":"H(+) + pyruvate => acetaldehyde + CO2"}
{"X":47069,"RHEA_ID":55476,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + N-acyleicosasphinganine + O2 = 2 [Fe(III)-cytochrome b5] + H2O + N-acyl-4-hydroxyeicosasphinganine"}
{"X":47070,"RHEA_ID":55478,"compounds":"2 [Fe(III)-cytochrome b5] + H2O + N-acyl-4-hydroxyeicosasphinganine => 2 [Fe(II)-cytochrome b5] + 2 H(+) + N-acyleicosasphinganine + O2"}
{"X":47071,"RHEA_ID":45489,"compounds":"[C-phycocyanin beta-subunit]-Cys(84)-phycocyanobilin => (2R,3E)-phycocyanobilin + apo-[C-phycocyanin beta-subunit]"}
{"X":47072,"RHEA_ID":55480,"DIRECTION":"UN","MASTER_ID":55480,"ec":"1.14.14.69","compounds":"ent-cassa-12,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = ent-3beta-hydroxycassa-12,15-dien-2-one + 3 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}
{"X":47073,"RHEA_ID":45491,"compounds":"[C-phycocyanin beta-subunit]-Cys(84)-phycocyanobilin <=> (2R,3E)-phycocyanobilin + apo-[C-phycocyanin beta-subunit]"}
{"X":47074,"RHEA_ID":45492,"DIRECTION":"UN","MASTER_ID":45492,"ec":"4.4.1.29","compounds":"[phycoerythrocyanin beta-subunit]-Cys(84)-phycocyanobilin = (2R,3E)-phycocyanobilin + apo-[phycoerythrocyanin beta-subunit]"}
{"X":47075,"RHEA_ID":45493,"compounds":"[phycoerythrocyanin beta-subunit]-Cys(84)-phycocyanobilin => (2R,3E)-phycocyanobilin + apo-[phycoerythrocyanin beta-subunit]"}
{"X":47076,"RHEA_ID":48797,"compounds":"O2 + prostaglandin H1 + reduced [NADPH--hemoprotein reductase] => 19-hydroxyprostaglandin H1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47077,"RHEA_ID":45495,"compounds":"[phycoerythrocyanin beta-subunit]-Cys(84)-phycocyanobilin <=> (2R,3E)-phycocyanobilin + apo-[phycoerythrocyanin beta-subunit]"}
{"X":47078,"RHEA_ID":45496,"DIRECTION":"UN","MASTER_ID":45496,"ec":"4.4.1.29","compounds":"[allophycocyanin alpha-subunit]-Cys(84)-phycocyanobilin = (2R,3E)-phycocyanobilin + apo-[allophycocyanin alpha-subunit]"}
{"X":47079,"RHEA_ID":45497,"compounds":"[allophycocyanin alpha-subunit]-Cys(84)-phycocyanobilin => (2R,3E)-phycocyanobilin + apo-[allophycocyanin alpha-subunit]"}
{"X":47080,"RHEA_ID":48801,"compounds":"a neolactoside nLc4Cer + GDP-beta-L-fucose => a neolactoside IV(2)-alpha-Fuc-nLc4Cer + GDP + H(+)"}
{"X":47081,"RHEA_ID":55488,"compounds":"ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = ent-cassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47082,"RHEA_ID":55489,"DIRECTION":"LR","MASTER_ID":55488,"metacyc":"RXN-18941","compounds":"ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47083,"RHEA_ID":45501,"compounds":"[allophycocyanin beta-subunit]-Cys(84)-phycocyanobilin => (2R,3E)-phycocyanobilin + apo-[allophycocyanin beta-subunit]"}
{"X":47084,"RHEA_ID":48805,"compounds":"(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 => (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O"}
{"X":47085,"RHEA_ID":55492,"compounds":"ent-cassa-12,15-dien-2-one + O2 + reduced [NADPH--hemoprotein reductase] = ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47086,"RHEA_ID":45504,"DIRECTION":"UN","MASTER_ID":45504,"ec":"4.4.1.29","compounds":"[C-phycoerythrin alpha-subunit]-Cys(84)-phycoerythrobilin = (2R,3E)-phycoerythrobilin + apo-[C-phycoerythrin alpha-subunit]"}
{"X":47087,"RHEA_ID":45505,"compounds":"[C-phycoerythrin alpha-subunit]-Cys(84)-phycoerythrobilin => (2R,3E)-phycoerythrobilin + apo-[C-phycoerythrin alpha-subunit]"}
{"X":47088,"RHEA_ID":45506,"DIRECTION":"RL","MASTER_ID":45504,"metacyc":"RXN-15997","compounds":"(2R,3E)-phycoerythrobilin + apo-[C-phycoerythrin alpha-subunit] => [C-phycoerythrin alpha-subunit]-Cys(84)-phycoerythrobilin"}
{"X":47089,"RHEA_ID":45507,"compounds":"[C-phycoerythrin alpha-subunit]-Cys(84)-phycoerythrobilin <=> (2R,3E)-phycoerythrobilin + apo-[C-phycoerythrin alpha-subunit]"}
{"X":47090,"RHEA_ID":45508,"DIRECTION":"UN","MASTER_ID":45508,"ec":"4.4.1.29","compounds":"[C-phycoerythrin beta-subunit]-Cys(84)-phycoerythrobilin = (2R,3E)-phycoerythrobilin + apo-[C-phycoerythrin beta-subunit]"}
{"X":47091,"RHEA_ID":45509,"compounds":"[C-phycoerythrin beta-subunit]-Cys(84)-phycoerythrobilin => (2R,3E)-phycoerythrobilin + apo-[C-phycoerythrin beta-subunit]"}
{"X":47092,"RHEA_ID":48813,"compounds":"(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 => (5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O"}
{"X":47093,"RHEA_ID":45511,"compounds":"[C-phycoerythrin beta-subunit]-Cys(84)-phycoerythrobilin <=> (2R,3E)-phycoerythrobilin + apo-[C-phycoerythrin beta-subunit]"}
{"X":47094,"RHEA_ID":55501,"DIRECTION":"LR","MASTER_ID":55500,"metacyc":"RXN-18946","compounds":"ent-cassa-12,15-dien-2beta,3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47095,"RHEA_ID":45513,"compounds":"[C-phycocyanin beta-subunit]-Cys(155)-phycocyanobilin => (2R,3E)-phycocyanobilin + apo-[C-phycocyanin beta-subunit]-Cys(155)"}
{"X":47096,"RHEA_ID":48817,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 => 17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O"}
{"X":47097,"RHEA_ID":55504,"DIRECTION":"UN","MASTER_ID":55504,"ec":"1.14.14.72","compounds":"(5S,9S,10S)-drim-7-en-11-ol + O2 + reduced [NADPH--hemoprotein reductase] = (5S,10S)-(9R)-7-drimene-11,12-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47098,"RHEA_ID":55505,"DIRECTION":"LR","MASTER_ID":55504,"metacyc":"RXN-19012","compounds":"(5S,9S,10S)-drim-7-en-11-ol + O2 + reduced [NADPH--hemoprotein reductase] => (5S,10S)-(9R)-7-drimene-11,12-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47099,"RHEA_ID":45517,"compounds":"[phycoerythrocyanin beta-subunit]-Cys(155)-phycocyanobilin => (2R,3E)-phycocyanobilin + apo-[phycoerythrocyanin beta-subunit]-Cys(155)"}
{"X":47100,"RHEA_ID":48821,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 => 13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O"}
{"X":47101,"RHEA_ID":45519,"compounds":"[phycoerythrocyanin beta-subunit]-Cys(155)-phycocyanobilin <=> (2R,3E)-phycocyanobilin + apo-[phycoerythrocyanin beta-subunit]-Cys(155)"}
{"X":47102,"RHEA_ID":55509,"DIRECTION":"LR","MASTER_ID":55508,"metacyc":"RXN-18955","compounds":"cucurbitadienol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 11-oxocucurbitadienol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":47103,"RHEA_ID":45521,"compounds":"[phycoerythrocyanin alpha-subunit]-Cys(84)-phycoviolobilin => (2R,3E)-phycocyanobilin + apo-[phycoerythrocyanin alpha-subunit]"}
{"X":47104,"RHEA_ID":45522,"DIRECTION":"RL","MASTER_ID":45520,"metacyc":"RXN-15988","compounds":"(2R,3E)-phycocyanobilin + apo-[phycoerythrocyanin alpha-subunit] => [phycoerythrocyanin alpha-subunit]-Cys(84)-phycoviolobilin"}
{"X":47105,"RHEA_ID":48826,"compounds":"a lactoside III(4)-a-Fuc-Lc4Cer + GDP + H(+) => GDP-beta-L-fucose + Lc4Cer"}
{"X":47106,"RHEA_ID":48827,"compounds":"GDP-beta-L-fucose + Lc4Cer <=> a lactoside III(4)-a-Fuc-Lc4Cer + GDP + H(+)"}
{"X":47107,"RHEA_ID":45525,"compounds":"[C-phycocyanin alpha-subunit]-Cys(84)-phycocyanobilin => (2R,3E)-phycocyanobilin + apo-[C-phycocyanin alpha-subunit]"}
{"X":47108,"RHEA_ID":45526,"DIRECTION":"RL","MASTER_ID":45524,"metacyc":"RXN-15984","compounds":"(2R,3E)-phycocyanobilin + apo-[C-phycocyanin alpha-subunit] => [C-phycocyanin alpha-subunit]-Cys(84)-phycocyanobilin"}
{"X":47109,"RHEA_ID":45527,"compounds":"[C-phycocyanin alpha-subunit]-Cys(84)-phycocyanobilin <=> (2R,3E)-phycocyanobilin + apo-[C-phycocyanin alpha-subunit]"}
{"X":47110,"RHEA_ID":55517,"DIRECTION":"LR","MASTER_ID":55516,"metacyc":"RXN-18954","compounds":"11-hydroxycucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase] => 11-oxocucurbitadienol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47111,"RHEA_ID":45529,"compounds":"H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine"}
{"X":47112,"RHEA_ID":45530,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":47113,"RHEA_ID":55520,"DIRECTION":"UN","MASTER_ID":55520,"ec":"2.5.1.142","compounds":"dimethylallyl diphosphate + 3 isopentenyl diphosphate = 3 diphosphate + nerylneryl diphosphate"}
{"X":47114,"RHEA_ID":55521,"DIRECTION":"LR","MASTER_ID":55520,"metacyc":"RXN-18856","compounds":"dimethylallyl diphosphate + 3 isopentenyl diphosphate => 3 diphosphate + nerylneryl diphosphate"}
{"X":47115,"RHEA_ID":45533,"compounds":"H2O + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine"}
{"X":47116,"RHEA_ID":45534,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine => H2O + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":47117,"RHEA_ID":45535,"compounds":"H2O + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine"}
{"X":47118,"RHEA_ID":55525,"DIRECTION":"LR","MASTER_ID":55524,"metacyc":"RXN-19275","compounds":"H(+) + H2O + L-dopa + O2 => 3,4-dihydroxyphenylacetaldehyde + CO2 + H2O2 + NH4(+)"}
{"X":47119,"RHEA_ID":45537,"compounds":"H2O + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-octadecanoyl ethanolamine"}
{"X":47120,"RHEA_ID":45538,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-octadecanoyl ethanolamine => H2O + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":47121,"RHEA_ID":45539,"compounds":"H2O + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-octadecanoyl ethanolamine"}
{"X":47122,"RHEA_ID":58873,"DIRECTION":"LR","MASTER_ID":58872,"metacyc":"RXN-11930","compounds":"24-methylidenelophenol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":47123,"RHEA_ID":45541,"compounds":"H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}
{"X":47124,"RHEA_ID":45542,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":47125,"RHEA_ID":45543,"compounds":"H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}
{"X":47126,"RHEA_ID":55533,"DIRECTION":"LR","MASTER_ID":55532,"metacyc":"RXN-8990","compounds":"H(+) + H2O + L-phenylalanine + O2 => 2-phenylacetaldehyde + CO2 + H2O2 + NH4(+)"}
{"X":47127,"RHEA_ID":45545,"compounds":"H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine"}
{"X":47128,"RHEA_ID":45546,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":47129,"RHEA_ID":45547,"compounds":"H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine"}
{"X":47130,"RHEA_ID":55537,"compounds":"an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose => a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+)"}
{"X":47131,"RHEA_ID":45549,"compounds":"[R-phycocyanin alpha-subunit]-Cys(84)-phycourobilin => (2R,3E)-phycoerythrobilin + apo-[R-phycocyanin alpha-subunit]"}
{"X":47132,"RHEA_ID":45550,"DIRECTION":"RL","MASTER_ID":45548,"metacyc":"RXN-15990","compounds":"(2R,3E)-phycoerythrobilin + apo-[R-phycocyanin alpha-subunit] => [R-phycocyanin alpha-subunit]-Cys(84)-phycourobilin"}
{"X":47133,"RHEA_ID":45551,"compounds":"[R-phycocyanin alpha-subunit]-Cys(84)-phycourobilin <=> (2R,3E)-phycoerythrobilin + apo-[R-phycocyanin alpha-subunit]"}
{"X":47134,"RHEA_ID":55541,"DIRECTION":"LR","MASTER_ID":55540,"metacyc":"RXN-19345","compounds":"40 ATP + 40 H2O + N2 + 12 reduced [2Fe-2S]-[ferredoxin] => 40 ADP + 26 H(+) + 3 H2 + 2 NH4(+) + 12 oxidized [2Fe-2S]-[ferredoxin] + 40 phosphate"}
{"X":47135,"RHEA_ID":45553,"compounds":"H2O + N-tetradecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-tetradecanoylethanolamine"}
{"X":47136,"RHEA_ID":45554,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-tetradecanoylethanolamine => H2O + N-tetradecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":47137,"RHEA_ID":55544,"compounds":"L-lysyl-[citrate synthase] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine"}
{"X":47138,"RHEA_ID":45556,"compounds":"H2O + N-dodecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-dodecanoylethanolamine"}
{"X":47139,"RHEA_ID":55546,"compounds":"H(+) + N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine => L-lysyl-[citrate synthase] + S-adenosyl-L-methionine"}
{"X":47140,"RHEA_ID":45558,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-dodecanoylethanolamine => H2O + N-dodecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":47141,"RHEA_ID":55548,"compounds":"N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine"}
{"X":47142,"RHEA_ID":55549,"compounds":"N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine"}
{"X":47143,"RHEA_ID":55550,"compounds":"H(+) + N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine"}
{"X":47144,"RHEA_ID":45562,"compounds":"D-allo-isoleucine => L-isoleucine"}
{"X":47145,"RHEA_ID":48866,"compounds":"FAD + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine => 2-methylpropan-1-amine + FADH2 + O2"}
{"X":47146,"RHEA_ID":45564,"DIRECTION":"UN","MASTER_ID":45564,"ec":"5.1.3.33","compounds":"2-epi-5-epi-valiolone = 5-epi-valiolone"}
{"X":47147,"RHEA_ID":45565,"DIRECTION":"LR","MASTER_ID":45564,"metacyc":"RXN-9141","compounds":"2-epi-5-epi-valiolone => 5-epi-valiolone"}
{"X":47148,"RHEA_ID":45566,"compounds":"5-epi-valiolone => 2-epi-5-epi-valiolone"}
{"X":47149,"RHEA_ID":55556,"DIRECTION":"UN","MASTER_ID":55556,"ec":"4.2.1.152","compounds":"a hydroperoxyeicosatetraenoate = an oxoeicosatetraenoate + H2O"}
{"X":47150,"RHEA_ID":45568,"DIRECTION":"UN","MASTER_ID":45568,"ec":"5.1.3.36","compounds":"[heparosan](n) = [acharan](n)"}
{"X":47151,"RHEA_ID":55558,"compounds":"an oxoeicosatetraenoate + H2O => a hydroperoxyeicosatetraenoate"}
{"X":47152,"RHEA_ID":45570,"compounds":"[acharan](n) => [heparosan](n)"}
{"X":47153,"RHEA_ID":45571,"DIRECTION":"BI","MASTER_ID":45568,"metacyc":"RXN-16431","compounds":"[heparosan](n) <=> [acharan](n)"}
{"X":47154,"RHEA_ID":55561,"compounds":"a hydroperoxyeicosatetraenoate => a hydroxy epoxy eicosatetraenoate"}
{"X":47155,"RHEA_ID":55562,"compounds":"a hydroxy epoxy eicosatetraenoate => a hydroperoxyeicosatetraenoate"}
{"X":47156,"RHEA_ID":45574,"compounds":"[alginate](n) => [(1->4)-beta-D-mannuronosyl](n)"}
{"X":47157,"RHEA_ID":55565,"DIRECTION":"LR","MASTER_ID":55564,"metacyc":"RXN-19090","compounds":"4-hydroxytryptamine + ATP => 4-hydoxytryptamine 4-phosphate + ADP + H(+)"}
{"X":47158,"RHEA_ID":55566,"compounds":"4-hydoxytryptamine 4-phosphate + ADP + H(+) => 4-hydroxytryptamine + ATP"}
{"X":47159,"RHEA_ID":45578,"compounds":"(2S)-methylsuccinyl-CoA => (2R)-ethylmalonyl-CoA"}
{"X":47160,"RHEA_ID":55568,"DIRECTION":"UN","MASTER_ID":55568,"ec":"2.1.1.345","compounds":"4-hydoxytryptamine 4-phosphate + 2 S-adenosyl-L-methionine = 2 H(+) + psilocybin + 2 S-adenosyl-L-homocysteine"}
{"X":47161,"RHEA_ID":45580,"DIRECTION":"UN","MASTER_ID":45580,"ec":"5.4.1.4","compounds":"D-galactaro-1,5-lactone = D-galactaro-1,4-lactone"}
{"X":47162,"RHEA_ID":55570,"compounds":"2 H(+) + psilocybin + 2 S-adenosyl-L-homocysteine => 4-hydoxytryptamine 4-phosphate + 2 S-adenosyl-L-methionine"}
{"X":47163,"RHEA_ID":45582,"compounds":"D-galactaro-1,4-lactone => D-galactaro-1,5-lactone"}
{"X":47164,"RHEA_ID":48886,"compounds":"3,8-divinyl protochlorophyllide a + H(+) + NADPH => NADP(+) + protochlorophyllide a"}
{"X":47165,"RHEA_ID":55573,"DIRECTION":"LR","MASTER_ID":55572,"metacyc":"RXN-19091","compounds":"4-hydoxytryptamine 4-phosphate + S-adenosyl-L-methionine => 4-hydroxy-N-methyltryptamine 4-phosphate + H(+) + S-adenosyl-L-homocysteine"}
{"X":47166,"RHEA_ID":55574,"compounds":"4-hydroxy-N-methyltryptamine 4-phosphate + H(+) + S-adenosyl-L-homocysteine => 4-hydoxytryptamine 4-phosphate + S-adenosyl-L-methionine"}
{"X":47167,"RHEA_ID":45586,"compounds":"(2E)-butenoyl-CoA + H2O => 3-hydroxybutanoyl-CoA"}
{"X":47168,"RHEA_ID":45587,"compounds":"3-hydroxybutanoyl-CoA <=> (2E)-butenoyl-CoA + H2O"}
{"X":47169,"RHEA_ID":55577,"DIRECTION":"LR","MASTER_ID":55576,"metacyc":"RXN-19092","compounds":"4-hydroxy-N-methyltryptamine 4-phosphate + S-adenosyl-L-methionine => H(+) + psilocybin + S-adenosyl-L-homocysteine"}
{"X":47170,"RHEA_ID":45589,"DIRECTION":"LR","MASTER_ID":45588,"metacyc":"ACYLACPSYNTH-RXN","compounds":"a long-chain fatty acid + ATP + holo-[ACP] => a long-chain fatty acyl-[ACP] + AMP + diphosphate"}
{"X":47171,"RHEA_ID":45590,"compounds":"a long-chain fatty acyl-[ACP] + AMP + diphosphate => a long-chain fatty acid + ATP + holo-[ACP]"}
{"X":47172,"RHEA_ID":55580,"DIRECTION":"UN","MASTER_ID":55580,"ec":"2.7.3.13","compounds":"ATP + H2O + L-glutamine = AMP + 2 H(+) + N(5)-phospho-L-glutamine + phosphate"}
{"X":47173,"RHEA_ID":55581,"DIRECTION":"LR","MASTER_ID":55580,"metacyc":"RXN-18998","compounds":"ATP + H2O + L-glutamine => AMP + 2 H(+) + N(5)-phospho-L-glutamine + phosphate"}
{"X":47174,"RHEA_ID":48896,"DIRECTION":"UN","MASTER_ID":48896,"ec":"1.3.7.13","compounds":"2 oxidized [2Fe-2S]-[ferredoxin] + protochlorophyllide a = 3,8-divinyl protochlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":47175,"RHEA_ID":45594,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => H2O + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":47176,"RHEA_ID":45595,"compounds":"H2O + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}
{"X":47177,"RHEA_ID":45596,"compounds":"H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}
{"X":47178,"RHEA_ID":48900,"DIRECTION":"UN","MASTER_ID":48900,"ec":"1.3.7.13","compounds":"chlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin] = 3,8-divinyl chlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":47179,"RHEA_ID":45598,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":47180,"RHEA_ID":55588,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-acyl-sphingoid base = a 1,2-diacyl-sn-glycerol + inositol phosphoceramide"}
{"X":47181,"RHEA_ID":55589,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-acyl-sphingoid base => a 1,2-diacyl-sn-glycerol + inositol phosphoceramide"}
{"X":47182,"RHEA_ID":48904,"DIRECTION":"UN","MASTER_ID":48904,"ec":"2.4.1.255","compounds":"L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H(+) + UDP"}
{"X":47183,"RHEA_ID":45602,"compounds":"5-dehydro-4-deoxy-D-glucarate + H(+) => D-galactaro-1,4-lactone"}
{"X":47184,"RHEA_ID":55592,"compounds":"2 (3R)-hydroxydecanoyl-[ACP] + H2O = (3R)-3-[(3R)-3-hydroxydecanoyloxy]decanoate + H(+) + 2 holo-[ACP]"}
{"X":47185,"RHEA_ID":55593,"compounds":"2 (3R)-hydroxydecanoyl-[ACP] + H2O => (3R)-3-[(3R)-3-hydroxydecanoyloxy]decanoate + H(+) + 2 holo-[ACP]"}
{"X":47186,"RHEA_ID":48908,"DIRECTION":"UN","MASTER_ID":48908,"ec":"2.4.1.255","compounds":"L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP"}
{"X":47187,"RHEA_ID":45606,"compounds":"5-dehydro-4-deoxy-D-glucarate + H(+) => D-glucaro-1,4-lactone"}
{"X":47188,"RHEA_ID":55596,"compounds":"globoside NOR1 + UDP-N-acetyl-alpha-D-galactosamine = globoside NORint + H(+) + UDP"}
{"X":47189,"RHEA_ID":55597,"compounds":"globoside NOR1 + UDP-N-acetyl-alpha-D-galactosamine => globoside NORint + H(+) + UDP"}
{"X":47190,"RHEA_ID":55598,"compounds":"globoside NORint + H(+) + UDP => globoside NOR1 + UDP-N-acetyl-alpha-D-galactosamine"}
{"X":47191,"RHEA_ID":45610,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-decanoyl ethanolamine => H2O + N-decanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":47192,"RHEA_ID":45611,"compounds":"H2O + N-decanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-decanoyl ethanolamine"}
{"X":47193,"RHEA_ID":45612,"compounds":"H2O + N-octanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-octanoyl ethanolamine"}
{"X":47194,"RHEA_ID":55602,"compounds":"a mannosylinositol-1-phosphoceramide + GDP + H(+) => an inositol-1-phosphoceramide + GDP-alpha-D-mannose"}
{"X":47195,"RHEA_ID":45614,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-octanoyl ethanolamine => H2O + N-octanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":47196,"RHEA_ID":45615,"compounds":"H2O + N-octanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-octanoyl ethanolamine"}
{"X":47197,"RHEA_ID":55605,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-acyl-sphingoid base => a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-acylsphingoid base"}
{"X":47198,"RHEA_ID":55606,"compounds":"a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-acylsphingoid base => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-acyl-sphingoid base"}
{"X":47199,"RHEA_ID":45618,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexanoyl ethanolamine => H2O + N-hexanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":47200,"RHEA_ID":55608,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base = a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base"}
{"X":47201,"RHEA_ID":55609,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base => a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base"}
{"X":47202,"RHEA_ID":55610,"compounds":"a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base"}
{"X":47203,"RHEA_ID":45622,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-butanoyl ethanolamine => H2O + N-butanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":47204,"RHEA_ID":48926,"compounds":"CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine => CMP-N-acetyl-beta-neuraminate + ganglioside GM4 (d18:1(4E))"}
{"X":47205,"RHEA_ID":45624,"DIRECTION":"UN","MASTER_ID":45624,"ec":"6.2.1.46","compounds":"ATP + holo-[CmaA peptidyl-carrier protein] + L-alloisoleucine = AMP + diphosphate + L-alloisoleucyl-[CmaA peptidyl-carrier protein]"}
{"X":47206,"RHEA_ID":55618,"compounds":"a carotenoid epsilon-end group => a carotenoid psi-end group"}
{"X":47207,"RHEA_ID":45626,"compounds":"AMP + diphosphate + L-alloisoleucyl-[CmaA peptidyl-carrier protein] => ATP + holo-[CmaA peptidyl-carrier protein] + L-alloisoleucine"}
{"X":47208,"RHEA_ID":48930,"compounds":"CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide => CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-D-galactosylceramide"}
{"X":47209,"RHEA_ID":45628,"DIRECTION":"UN","MASTER_ID":45628,"ec":"2.3.2.28","compounds":"holo-[CmaD peptidyl-carrier protein] + L-alloisoleucyl-[CmaA peptidyl-carrier protein] = holo-[CmaA peptidyl-carrier protein] + L-alloisoleucyl-[CmaD peptidyl-carrier protein]"}
{"X":47210,"RHEA_ID":55622,"compounds":"a carotenoid beta-end derivative => a carotenoid psi-end group"}
{"X":47211,"RHEA_ID":58971,"compounds":"1-naphthaldehyde + H2O + O2 <=> 1-naphthoate + H(+) + H2O2"}
{"X":47212,"RHEA_ID":48934,"compounds":"CMP + ganglioside GQ1b + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GT1b"}
{"X":47213,"RHEA_ID":55633,"compounds":"1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)"}
{"X":47214,"RHEA_ID":55634,"compounds":"1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+) => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP"}
{"X":47215,"RHEA_ID":45634,"compounds":"1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O"}
{"X":47216,"RHEA_ID":45635,"compounds":"1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate"}
{"X":47217,"RHEA_ID":45636,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate"}
{"X":47218,"RHEA_ID":55638,"compounds":"AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + diphosphate + H(+) + phosphate => ATP + C-terminal L-cysteinyl-[HypE protein] + carbamoyl phosphate + H2O"}
{"X":47219,"RHEA_ID":45638,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + H2O"}
{"X":47220,"RHEA_ID":55640,"compounds":"C-terminal L-cysteinyl-[HypE protein] + carbamoyl adenylate = AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + H(+)"}
{"X":47221,"RHEA_ID":55641,"DIRECTION":"LR","MASTER_ID":55640,"ecocyc":"RXN-15915","metacyc":"RXN-15915","compounds":"C-terminal L-cysteinyl-[HypE protein] + carbamoyl adenylate => AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + H(+)"}
{"X":47222,"RHEA_ID":55642,"compounds":"AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + H(+) => C-terminal L-cysteinyl-[HypE protein] + carbamoyl adenylate"}
{"X":47223,"RHEA_ID":48944,"DIRECTION":"UN","MASTER_ID":48944,"ec":"1.3.7.15","compounds":"ADP + bacteriochlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate = 3-acetyl-3-devinylchlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":47224,"RHEA_ID":48945,"compounds":"ADP + bacteriochlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate => 3-acetyl-3-devinylchlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":47225,"RHEA_ID":55645,"DIRECTION":"LR","MASTER_ID":55644,"ecocyc":"RXN-17943","metacyc":"RXN-17943","compounds":"ATP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] => ADP + C-terminal S-cyanate-L-cysteinyl-[HypE protein] + H(+) + phosphate"}
{"X":47226,"RHEA_ID":55646,"compounds":"ADP + C-terminal S-cyanate-L-cysteinyl-[HypE protein] + H(+) + phosphate => ATP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein]"}
{"X":47227,"RHEA_ID":45646,"compounds":"H(+) + N-hexadecanoylsphing-4-enine + phosphocholine => H2O + N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine"}
{"X":47228,"RHEA_ID":55648,"compounds":"2-oxoglutarate + O2 + validoxylamine A = CO2 + H(+) + succinate + validoxylamine B"}
{"X":47229,"RHEA_ID":45648,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}
{"X":47230,"RHEA_ID":58990,"compounds":"(E)-4-hydroxynon-2-enoate + H(+) + H2O2 => (E)-4-hydroxynon-2-enal + H2O + O2"}
{"X":47231,"RHEA_ID":48952,"compounds":"14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+) = 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + H(+) + NADH"}
{"X":47232,"RHEA_ID":48953,"compounds":"14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+) => 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + H(+) + NADH"}
{"X":47233,"RHEA_ID":55653,"compounds":"1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}
{"X":47234,"RHEA_ID":45653,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}
{"X":47235,"RHEA_ID":55655,"compounds":"1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}
{"X":47236,"RHEA_ID":45655,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}
{"X":47237,"RHEA_ID":55657,"DIRECTION":"LR","MASTER_ID":55656,"metacyc":"RXN-19144","compounds":"2 A + a carotenoid beta-end derivative => a carotenoid chi-end derivative + 2 AH2"}
{"X":47238,"RHEA_ID":45657,"compounds":"1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CTP + H(+) => 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}
{"X":47239,"RHEA_ID":48960,"DIRECTION":"UN","MASTER_ID":48960,"ec":"1.11.1.8","compounds":"[thyroglobulin]-3-iodo-L-tyrosine + H(+) + H2O2 + iodide = [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O"}
{"X":47240,"RHEA_ID":45659,"compounds":"1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CTP + H(+) <=> 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}
{"X":47241,"RHEA_ID":55661,"DIRECTION":"LR","MASTER_ID":55660,"metacyc":"RXN-8184","compounds":"2 AH2 + all-trans-beta-carotene + 2 O2 => 2 A + echinenone + 3 H2O"}
{"X":47242,"RHEA_ID":45661,"compounds":"1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) => 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}
{"X":47243,"RHEA_ID":45662,"compounds":"1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+)"}
{"X":47244,"RHEA_ID":45663,"compounds":"1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}
{"X":47245,"RHEA_ID":55665,"DIRECTION":"LR","MASTER_ID":55664,"metacyc":"RXN-8185","compounds":"2 AH2 + echinenone + 2 O2 => 2 A + canthaxanthin + 3 H2O"}
{"X":47246,"RHEA_ID":45665,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}
{"X":47247,"RHEA_ID":45666,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+)"}
{"X":47248,"RHEA_ID":55668,"DIRECTION":"UN","MASTER_ID":55668,"ec":"1.1.1.315","compounds":"11-cis-retinol--[retinol-binding protein] + NAD(+) = 11-cis-retinal--[retinol-binding protein] + H(+) + NADH"}
{"X":47249,"RHEA_ID":55669,"DIRECTION":"LR","MASTER_ID":55668,"metacyc":"RXN-12551","compounds":"11-cis-retinol--[retinol-binding protein] + NAD(+) => 11-cis-retinal--[retinol-binding protein] + H(+) + NADH"}
{"X":47250,"RHEA_ID":45669,"compounds":"1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CTP + H(+) => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}
{"X":47251,"RHEA_ID":45670,"compounds":"1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CTP + H(+)"}
{"X":47252,"RHEA_ID":55672,"DIRECTION":"UN","MASTER_ID":55672,"ec":"2.4.1.355","compounds":"4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine = 4-O-([2-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP"}
{"X":47253,"RHEA_ID":55673,"compounds":"4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine => 4-O-([2-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP"}
{"X":47254,"RHEA_ID":45673,"compounds":"1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}
{"X":47255,"RHEA_ID":48976,"DIRECTION":"UN","MASTER_ID":48976,"ec":"1.14.13.218","compounds":"5-methyl-phenazine-1-carboxylate + 2 H(+) + NADH + O2 = CO2 + H2O + NAD(+) + pyocyanin"}
{"X":47256,"RHEA_ID":55688,"compounds":"an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + H2O = 1D-myo-inositol 1-phosphate + an N-acyl-(4R)-4-hydroxysphinganine + H(+)"}
{"X":47257,"RHEA_ID":55689,"compounds":"an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + H2O => 1D-myo-inositol 1-phosphate + an N-acyl-(4R)-4-hydroxysphinganine + H(+)"}
{"X":47258,"RHEA_ID":45677,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate"}
{"X":47259,"RHEA_ID":55691,"compounds":"an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + H2O <=> 1D-myo-inositol 1-phosphate + an N-acyl-(4R)-4-hydroxysphinganine + H(+)"}
{"X":47260,"RHEA_ID":55692,"compounds":"H2O + inositol phosphoceramide = 1D-myo-inositol 1-phosphate + H(+) + N-acyl-sphingoid base"}
{"X":47261,"RHEA_ID":55693,"compounds":"H2O + inositol phosphoceramide => 1D-myo-inositol 1-phosphate + H(+) + N-acyl-sphingoid base"}
{"X":47262,"RHEA_ID":45681,"compounds":"N-(hexadecanoyl)-sphing-4-enine-1-phosphate(in) => N-(hexadecanoyl)-sphing-4-enine-1-phosphate(out)"}
{"X":47263,"RHEA_ID":45682,"compounds":"N-(hexadecanoyl)-sphing-4-enine-1-phosphate(out) => N-(hexadecanoyl)-sphing-4-enine-1-phosphate(in)"}
{"X":47264,"RHEA_ID":55696,"compounds":"a mannosylinositol-1-phospho-N-acyl-sphingoid base + H2O = H(+) + mannosylinositol-1-phosphate + N-acyl-sphingoid base"}
{"X":47265,"RHEA_ID":55697,"compounds":"a mannosylinositol-1-phospho-N-acyl-sphingoid base + H2O => H(+) + mannosylinositol-1-phosphate + N-acyl-sphingoid base"}
{"X":47266,"RHEA_ID":45685,"compounds":"N-(dodecanoyl)-sphing-4-enine-1-phosphate(in) => N-(dodecanoyl)-sphing-4-enine-1-phosphate(out)"}
{"X":47267,"RHEA_ID":48988,"DIRECTION":"UN","MASTER_ID":48988,"ec":"1.14.13.211","compounds":"NADH + O2 + rifampicin = 2'-N-hydroxyrifampicin + H2O + NAD(+)"}
{"X":47268,"RHEA_ID":55700,"compounds":"an inositol phosphomannosylinositol-1-phospho-N-acyl-(4R)-4-hydroxysphinganine + H2O = an N-acyl-(4R)-4-hydroxysphinganine + H(+) + mannosyldiinositol-1-phosphate"}
{"X":47269,"RHEA_ID":45688,"compounds":"N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(in) = N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(out)"}
{"X":47270,"RHEA_ID":45689,"compounds":"N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(in) => N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(out)"}
{"X":47271,"RHEA_ID":55703,"compounds":"an inositol phosphomannosylinositol-1-phospho-N-acyl-(4R)-4-hydroxysphinganine + H2O <=> an N-acyl-(4R)-4-hydroxysphinganine + H(+) + mannosyldiinositol-1-phosphate"}
{"X":47272,"RHEA_ID":55704,"DIRECTION":"UN","MASTER_ID":55704,"ec":"2.4.2.59","compounds":"glycine + hydrogen sulfide + NAD(+) = ADP-5-ethyl-4-methylthiazole-2-carboxylate + H(+) + 3 H2O + nicotinamide"}
{"X":47273,"RHEA_ID":55705,"DIRECTION":"LR","MASTER_ID":55704,"metacyc":"RXN-19351","compounds":"glycine + hydrogen sulfide + NAD(+) => ADP-5-ethyl-4-methylthiazole-2-carboxylate + H(+) + 3 H2O + nicotinamide"}
{"X":47274,"RHEA_ID":59034,"compounds":"4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O => (Z)-24-ethylidenelophenol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}
{"X":47275,"RHEA_ID":55706,"compounds":"ADP-5-ethyl-4-methylthiazole-2-carboxylate + H(+) + 3 H2O + nicotinamide => glycine + hydrogen sulfide + NAD(+)"}
{"X":47276,"RHEA_ID":55708,"DIRECTION":"UN","MASTER_ID":55708,"ec":"2.4.2.60","compounds":"[ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) = [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 2 H(+) + 3 H2O + nicotinamide"}
{"X":47277,"RHEA_ID":55709,"DIRECTION":"LR","MASTER_ID":55708,"metacyc":"RXNQT-4300","compounds":"[ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) => [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 2 H(+) + 3 H2O + nicotinamide"}
{"X":47278,"RHEA_ID":45697,"compounds":"N-(acetyl)-sphing-4-enine-1-phosphate(in) => N-(acetyl)-sphing-4-enine-1-phosphate(out)"}
{"X":47279,"RHEA_ID":55710,"compounds":"[ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 2 H(+) + 3 H2O + nicotinamide => [ADP-thiazole synthase]-L-cysteine + glycine + NAD(+)"}
{"X":47280,"RHEA_ID":55712,"compounds":"(S,S)-3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O = (9Z)-octadecenoate + (S,S)-3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+)"}
{"X":47281,"RHEA_ID":55713,"compounds":"(S,S)-3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O => (9Z)-octadecenoate + (S,S)-3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+)"}
{"X":47282,"RHEA_ID":45701,"compounds":"betaine + H2O + O2 => formaldehyde + H2O2 + N,N-dimethylglycine"}
{"X":47283,"RHEA_ID":49004,"DIRECTION":"UN","MASTER_ID":49004,"ec":"1.14.13.222","compounds":"aurachin C + H(+) + NADPH + O2 = 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NADP(+)"}
{"X":47284,"RHEA_ID":45703,"compounds":"betaine + H2O + O2 <=> formaldehyde + H2O2 + N,N-dimethylglycine"}
{"X":47285,"RHEA_ID":45704,"DIRECTION":"UN","MASTER_ID":45704,"ec":"1.1.1.195","compounds":"(E)-sinapoyl alcohol + NADP(+) = (E)-sinapoaldehyde + H(+) + NADPH"}
{"X":47286,"RHEA_ID":45705,"compounds":"(E)-sinapoyl alcohol + NADP(+) => (E)-sinapoaldehyde + H(+) + NADPH"}
{"X":47287,"RHEA_ID":49008,"compounds":"aurachin C + H(+) + NADPH + O2 = aurachin C epoxide + H2O + NADP(+)"}
{"X":47288,"RHEA_ID":55720,"DIRECTION":"UN","MASTER_ID":55720,"ec":"6.2.1.51","compounds":"17-(4-hydroxyphenyl)heptadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] = 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate"}
{"X":47289,"RHEA_ID":45708,"compounds":"3-dehydrocarnitine + acetyl-CoA = 3-dehydrocarnityl-CoA + acetate"}
{"X":47290,"RHEA_ID":59050,"compounds":"CO2 + putrescine => D-ornithine + H(+)"}
{"X":47291,"RHEA_ID":55722,"compounds":"17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate => 17-(4-hydroxyphenyl)heptadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase]"}
{"X":47292,"RHEA_ID":55724,"compounds":"17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] = 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)"}
{"X":47293,"RHEA_ID":55725,"DIRECTION":"LR","MASTER_ID":55724,"metacyc":"RXN-18538","compounds":"17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] => 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)"}
{"X":47294,"RHEA_ID":45713,"compounds":"3-dehydrocarnityl-CoA + CoA => acetyl-CoA + N,N,N-trimethylglycyl-CoA"}
{"X":47295,"RHEA_ID":52398,"compounds":"CO2 + dihydroxyacetone phosphate + NADH => 4-O-phospho-D-threonate + NAD(+)"}
{"X":47296,"RHEA_ID":55728,"DIRECTION":"UN","MASTER_ID":55728,"ec":"6.2.1.51","compounds":"19-(4-hydroxyphenyl)nonadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] = 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate"}
{"X":47297,"RHEA_ID":55729,"DIRECTION":"LR","MASTER_ID":55728,"metacyc":"RXN-18537","compounds":"19-(4-hydroxyphenyl)nonadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] => 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate"}
{"X":47298,"RHEA_ID":45717,"compounds":"H2O + N,N,N-trimethylglycyl-CoA => betaine + CoA + H(+)"}
{"X":47299,"RHEA_ID":55730,"compounds":"19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate => 19-(4-hydroxyphenyl)nonadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase]"}
{"X":47300,"RHEA_ID":59060,"compounds":"(20S)-ginsenoside Rg3 + H2O = (20S)-ginsenoside Rh2 + D-glucose"}
{"X":47301,"RHEA_ID":45720,"compounds":"N-hexadecanoylsphing-4-enine(in) = N-hexadecanoylsphing-4-enine(out)"}
{"X":47302,"RHEA_ID":49023,"compounds":"2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one <=> 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide"}
{"X":47303,"RHEA_ID":49024,"DIRECTION":"UN","MASTER_ID":49024,"ec":"1.4.3.23","compounds":"L-tryptophan + O2 = 2-iminio-3-(indol-3-yl)propanoate + H2O2"}
{"X":47304,"RHEA_ID":59064,"DIRECTION":"UN","MASTER_ID":59064,"ec":"2.1.1.353","compounds":"demethylluteothin + S-adenosyl-L-methionine = luteothin + S-adenosyl-L-homocysteine"}
{"X":47305,"RHEA_ID":55737,"DIRECTION":"LR","MASTER_ID":55736,"metacyc":"RXN-18750","compounds":"alpha-D-galacturonosyl-[(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n) + UDP-beta-L-rhamnose => [(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP"}
{"X":47306,"RHEA_ID":45725,"compounds":"(E)-4-coumaroyl alcohol + NADP(+) => (E)-4-coumaraldehyde + H(+) + NADPH"}
{"X":47307,"RHEA_ID":49028,"DIRECTION":"UN","MASTER_ID":49028,"ec":"1.14.14.131","compounds":"(-)-bursehernin + O2 + reduced [NADPH--hemoprotein reductase] = (-)-5'-demethylyatein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47308,"RHEA_ID":59068,"DIRECTION":"UN","MASTER_ID":59068,"ec":"2.1.1.353","compounds":"demethyldeoxyspectinabilin + S-adenosyl-L-methionine = deoxyspectinabilin + S-adenosyl-L-homocysteine"}
{"X":47309,"RHEA_ID":55741,"DIRECTION":"LR","MASTER_ID":55740,"metacyc":"RXN-18857","compounds":"H2O + oleuropein => D-glucose + oleuropein aglycone"}
{"X":47310,"RHEA_ID":45729,"compounds":"(E)-caffeyl alcohol + NADP(+) => (E)-caffeyl aldehyde + H(+) + NADPH"}
{"X":47311,"RHEA_ID":49032,"DIRECTION":"UN","MASTER_ID":49032,"ec":"1.14.14.132","compounds":"(-)-4'-desmethyl-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase] = 4'-demethylepipodophyllotoxin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47312,"RHEA_ID":59072,"DIRECTION":"UN","MASTER_ID":59072,"ec":"2.1.1.308","compounds":"AH2 + cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + 2 S-adenosyl-L-methionine = 5'-deoxyadenosine + A + cytidine 5'-{[hydroxy(2-hydroxypropyl)phosphonoyl]phosphate} + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine"}
{"X":47313,"RHEA_ID":49034,"compounds":"4'-demethylepipodophyllotoxin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-4'-desmethyl-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":47314,"RHEA_ID":45733,"DIRECTION":"LR","MASTER_ID":45732,"metacyc":"RXN-19261","compounds":"D-ribulose 5-phosphate + L-tyrosine => (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate"}
{"X":47315,"RHEA_ID":49036,"DIRECTION":"UN","MASTER_ID":49036,"ec":"2.1.1.323","compounds":"(-)-pluviatolide + S-adenosyl-L-methionine = (-)-bursehernin + H(+) + S-adenosyl-L-homocysteine"}
{"X":47316,"RHEA_ID":59076,"DIRECTION":"UN","MASTER_ID":59076,"ec":"2.4.1.361","compounds":"bis(myo-inositol) 1,3'-phosphate + 2 GDP-alpha-D-mannose = 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + 2 GDP + 2 H(+)"}
{"X":47317,"RHEA_ID":49038,"compounds":"(-)-bursehernin + H(+) + S-adenosyl-L-homocysteine => (-)-pluviatolide + S-adenosyl-L-methionine"}
{"X":47318,"RHEA_ID":45737,"compounds":"(3E)-hexenoyl-CoA => (2E)-hexenoyl-CoA"}
{"X":47319,"RHEA_ID":49040,"DIRECTION":"UN","MASTER_ID":49040,"ec":"2.1.1.330","compounds":"(-)-5'-demethylyatein + S-adenosyl-L-methionine = (-)-yatein + H(+) + S-adenosyl-L-homocysteine"}
{"X":47320,"RHEA_ID":49041,"DIRECTION":"LR","MASTER_ID":49040,"metacyc":"RXN-17348","compounds":"(-)-5'-demethylyatein + S-adenosyl-L-methionine => (-)-yatein + H(+) + S-adenosyl-L-homocysteine"}
{"X":47321,"RHEA_ID":49042,"compounds":"(-)-yatein + H(+) + S-adenosyl-L-homocysteine => (-)-5'-demethylyatein + S-adenosyl-L-methionine"}
{"X":47322,"RHEA_ID":45741,"DIRECTION":"LR","MASTER_ID":45740,"metacyc":"RXN-18394","compounds":"2-oxoglutarate + L-ectoine + O2 => 5-hydroxyectoine + CO2 + succinate"}
{"X":47323,"RHEA_ID":49044,"DIRECTION":"UN","MASTER_ID":49044,"ec":"1.14.13.215","compounds":"H(+) + NADH + O2 + protoasukamycin = 4-hydroxyprotoasukamycin + H2O + NAD(+)"}
{"X":47324,"RHEA_ID":55756,"DIRECTION":"UN","MASTER_ID":55756,"ec":"1.14.11.58","compounds":"2-oxoglutarate + an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + O2 = a 2-hydroxyornithine lipid + CO2 + succinate"}
{"X":47325,"RHEA_ID":49046,"compounds":"4-hydroxyprotoasukamycin + H2O + NAD(+) => H(+) + NADH + O2 + protoasukamycin"}
{"X":47326,"RHEA_ID":45745,"compounds":"(6S)-5,6,7,8-tetrahydropteroate + NAD(+) => 7,8-dihydropteroate + H(+) + NADH"}
{"X":47327,"RHEA_ID":49048,"compounds":"25-hydroxyvitamin D2 + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 1alpha,25-dihydroxyvitamin D2 + H2O + 2 oxidized [adrenodoxin]"}
{"X":47328,"RHEA_ID":59088,"DIRECTION":"UN","MASTER_ID":59088,"ec":"2.5.1.152","compounds":"D-histidine + S-adenosyl-L-methionine = (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine"}
{"X":47329,"RHEA_ID":49050,"compounds":"1alpha,25-dihydroxyvitamin D2 + H2O + 2 oxidized [adrenodoxin] => 25-hydroxyvitamin D2 + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}
{"X":47330,"RHEA_ID":45749,"compounds":"(3Z)-hexenoyl-CoA => (2E)-hexenoyl-CoA"}
{"X":47331,"RHEA_ID":49052,"DIRECTION":"UN","MASTER_ID":49052,"ec":"1.14.13.216","compounds":"asperlicin C + H(+) + NADH + O2 = asperlicin E + H2O + NAD(+)"}
{"X":47332,"RHEA_ID":59092,"DIRECTION":"UN","MASTER_ID":59092,"ec":"2.4.1.372","compounds":"[(1->3)-alpha-D-glucosyl](n) + sucrose = [(1->3)-alpha-D-glucosyl](n+1) + D-fructose"}
{"X":47333,"RHEA_ID":55765,"DIRECTION":"LR","MASTER_ID":55764,"metacyc":"RXN-19352","compounds":"1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O => 2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol"}
{"X":47334,"RHEA_ID":45753,"DIRECTION":"LR","MASTER_ID":45752,"reactome":"R-HSA-109998.2","compounds":"(3E)-decenoyl-CoA => (2E)-decenoyl-CoA"}
{"X":47335,"RHEA_ID":49056,"DIRECTION":"UN","MASTER_ID":49056,"ec":"1.14.13.216","compounds":"asperlicin C + H(+) + NADPH + O2 = asperlicin E + H2O + NADP(+)"}
{"X":47336,"RHEA_ID":49057,"DIRECTION":"LR","MASTER_ID":49056,"metacyc":"RXN-15799","compounds":"asperlicin C + H(+) + NADPH + O2 => asperlicin E + H2O + NADP(+)"}
{"X":47337,"RHEA_ID":55769,"compounds":"all-trans-retinoate + UDP-alpha-D-glucuronate => all-trans-retinoyl-1-O-(beta-D-glucuronate) + UDP"}
{"X":47338,"RHEA_ID":45757,"compounds":"(6S)-5,6,7,8-tetrahydrofolate + N,N-dimethylglycine + O2 => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O2 + sarcosine"}
{"X":47339,"RHEA_ID":49060,"DIRECTION":"UN","MASTER_ID":49060,"ec":"1.14.14.28","compounds":"a long-chain alkane + FMNH2 + O2 = a long chain fatty alcohol + FMN + H(+) + H2O"}
{"X":47340,"RHEA_ID":55772,"DIRECTION":"UN","MASTER_ID":55772,"ec":"6.3.2.52","compounds":"a jasmonate + an L-alpha-amino acid + ATP = a jasmonyl-L-amino acid + AMP + diphosphate + H(+)"}
{"X":47341,"RHEA_ID":55773,"DIRECTION":"LR","MASTER_ID":55772,"metacyc":"RXN-18494","compounds":"a jasmonate + an L-alpha-amino acid + ATP => a jasmonyl-L-amino acid + AMP + diphosphate + H(+)"}
{"X":47342,"RHEA_ID":45761,"DIRECTION":"LR","MASTER_ID":45760,"metacyc":"RXN-14825","compounds":"dTDP-beta-L-daunosamine + epsilon-rhodomycinone => dTDP + H(+) + rhodomycin D"}
{"X":47343,"RHEA_ID":45762,"compounds":"dTDP + H(+) + rhodomycin D => dTDP-beta-L-daunosamine + epsilon-rhodomycinone"}
{"X":47344,"RHEA_ID":49065,"DIRECTION":"LR","MASTER_ID":49064,"metacyc":"RXN-18233","compounds":"2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol => calcitetrol + H2O + 2 oxidized [adrenodoxin]"}
{"X":47345,"RHEA_ID":49066,"compounds":"calcitetrol + H2O + 2 oxidized [adrenodoxin] => 2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol"}
{"X":47346,"RHEA_ID":45765,"compounds":"H2O + L-aspartate 4-semialdehyde + NAD(+) => 2 H(+) + L-aspartate + NADH"}
{"X":47347,"RHEA_ID":45766,"compounds":"2 H(+) + L-aspartate + NADH => H2O + L-aspartate 4-semialdehyde + NAD(+)"}
{"X":47348,"RHEA_ID":45767,"compounds":"H2O + L-aspartate 4-semialdehyde + NAD(+) <=> 2 H(+) + L-aspartate + NADH"}
{"X":47349,"RHEA_ID":49070,"compounds":"(1S)-1,25-dihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin] => 25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}
{"X":47350,"RHEA_ID":45769,"DIRECTION":"LR","MASTER_ID":45768,"metacyc":"RXN-8942","compounds":"gamma-glutamyl-L-alaninol + H2O => L-alaninol + L-glutamate"}
{"X":47351,"RHEA_ID":55782,"compounds":"all-trans-5,6-epoxyretinoyl-1-O-(beta-D-glucuronate) + UDP => all-trans-5,6-epoxyretinoate + UDP-alpha-D-glucuronate"}
{"X":47352,"RHEA_ID":45771,"compounds":"gamma-glutamyl-L-alaninol + H2O <=> L-alaninol + L-glutamate"}
{"X":47353,"RHEA_ID":55785,"compounds":"all-trans-4-oxoretinoate + UDP-alpha-D-glucuronate => all-trans-4-oxoretinoate 1-O-(beta-D-glucuronate) + UDP"}
{"X":47354,"RHEA_ID":45773,"compounds":"[(1->4)-beta-D-mannosyl](n) + phosphate => [(1->4)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate"}
{"X":47355,"RHEA_ID":59115,"compounds":"ATP + L-serine <=> ADP + H(+) + O-phospho-L-serine"}
{"X":47356,"RHEA_ID":55788,"compounds":"acetone + H(+) + NADH + O2 = H2O + hydroxyacetone + NAD(+)"}
{"X":47357,"RHEA_ID":55789,"DIRECTION":"LR","MASTER_ID":55788,"metacyc":"RXN-17569","compounds":"acetone + H(+) + NADH + O2 => H2O + hydroxyacetone + NAD(+)"}
{"X":47358,"RHEA_ID":55790,"compounds":"H2O + hydroxyacetone + NAD(+) => acetone + H(+) + NADH + O2"}
{"X":47359,"RHEA_ID":59119,"compounds":"[protein]-dithiol + O2 <=> [protein]-disulfide + H2O2"}
{"X":47360,"RHEA_ID":55792,"compounds":"butan-2-one + H(+) + NADH + O2 = 1-hydroxy-2-butanone + H2O + NAD(+)"}
{"X":47361,"RHEA_ID":55793,"compounds":"butan-2-one + H(+) + NADH + O2 => 1-hydroxy-2-butanone + H2O + NAD(+)"}
{"X":47362,"RHEA_ID":55794,"compounds":"1-hydroxy-2-butanone + H2O + NAD(+) => butan-2-one + H(+) + NADH + O2"}
{"X":47363,"RHEA_ID":46872,"DIRECTION":"UN","MASTER_ID":46872,"ec":"2.3.1.251","compounds":"1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IIA = a 2-acyl-sn-glycero-3-phosphocholine + lipid IIB"}
{"X":47364,"RHEA_ID":45783,"compounds":"(9Z)-octadecenoyl-CoA + di-(9Z)-octadecenoylglycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA"}
{"X":47365,"RHEA_ID":45784,"DIRECTION":"UN","MASTER_ID":45784,"ec":"3.5.5.1","compounds":"2 H2O + phenylpropanonitrile = 3-phenylpropanoate + NH4(+)"}
{"X":47366,"RHEA_ID":55798,"compounds":"H2O + hydroquinone + NAD(+) => H(+) + NADH + O2 + phenol"}
{"X":47367,"RHEA_ID":45786,"compounds":"3-phenylpropanoate + NH4(+) => 2 H2O + phenylpropanonitrile"}
{"X":47368,"RHEA_ID":45787,"compounds":"2 H2O + phenylpropanonitrile <=> 3-phenylpropanoate + NH4(+)"}
{"X":47369,"RHEA_ID":45788,"compounds":"(9Z)-hexadecenoyl-CoA + 1,2-dihexadecanoyl-sn-glycerol = 1,2-dihexadecanoyl-3-(9Z-hexadecenoyl)-sn-glycerol + CoA"}
{"X":47370,"RHEA_ID":45789,"compounds":"(9Z)-hexadecenoyl-CoA + 1,2-dihexadecanoyl-sn-glycerol => 1,2-dihexadecanoyl-3-(9Z-hexadecenoyl)-sn-glycerol + CoA"}
{"X":47371,"RHEA_ID":55802,"compounds":"2 [Fe(III)-cytochrome b5] + 2 H2O + N-acyleicosasphing-4-enine => 2 [Fe(II)-cytochrome b5] + 2 H(+) + N-acyleicosasphinganine + O2"}
{"X":47372,"RHEA_ID":55804,"compounds":"(R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(2'-(9Z-octadecenoyl)-3'-sn-glycerol) + H2O = (9Z)-octadecenoate + (R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(3'-sn-glycerol) + H(+)"}
{"X":47373,"RHEA_ID":45792,"compounds":"2-oxoglutarate + [ribosomal protein S23]-L-proline + O2 = [ribosomal protein S23]-trans-3-hydroxy-L-proline + CO2 + succinate"}
{"X":47374,"RHEA_ID":45793,"compounds":"2-oxoglutarate + [ribosomal protein S23]-L-proline + O2 => [ribosomal protein S23]-trans-3-hydroxy-L-proline + CO2 + succinate"}
{"X":47375,"RHEA_ID":45794,"compounds":"[ribosomal protein S23]-trans-3-hydroxy-L-proline + CO2 + succinate => 2-oxoglutarate + [ribosomal protein S23]-L-proline + O2"}
{"X":47376,"RHEA_ID":55808,"DIRECTION":"UN","MASTER_ID":55808,"ec":"1.14.18.5","compounds":"2 [Fe(II)-cytochrome b5] + a dihydroceramide + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a phytoceramide + H2O"}
{"X":47377,"RHEA_ID":45796,"DIRECTION":"UN","MASTER_ID":45796,"ec":"1.1.1.36","compounds":"(3R)-hydroxybutanoyl-CoA + NADP(+) = acetoacetyl-CoA + H(+) + NADPH"}
{"X":47378,"RHEA_ID":59138,"compounds":"AMP + diphosphate + H(+) + N(5)-[(S)-citryl]-D-ornithine => ATP + citrate + D-ornithine"}
{"X":47379,"RHEA_ID":49100,"compounds":"H2O + Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-methionine = 5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester"}
{"X":47380,"RHEA_ID":55812,"DIRECTION":"UN","MASTER_ID":55812,"ec":"1.17.98.2","compounds":"a bacteriochlorophyllide d + H2O + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + a bacteriochlorophyllide f + 2 H(+) + 2 L-methionine"}
{"X":47381,"RHEA_ID":45800,"compounds":"15-demethylaclacinomycin T + AH2 + O2 = 10-decarboxymethylaclacinomycin T + A + CO2 + H2O"}
{"X":47382,"RHEA_ID":59142,"compounds":"AMP + diphosphate + H(+) + staphyloferrin A => ATP + citrate + N(5)-[(S)-citryl]-D-ornithine"}
{"X":47383,"RHEA_ID":55814,"compounds":"2 5'-deoxyadenosine + a bacteriochlorophyllide f + 2 H(+) + 2 L-methionine => a bacteriochlorophyllide d + H2O + 2 S-adenosyl-L-methionine"}
{"X":47384,"RHEA_ID":49105,"DIRECTION":"LR","MASTER_ID":49104,"metacyc":"RXN-8798","compounds":"Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine => 5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester"}
{"X":47385,"RHEA_ID":45804,"compounds":"ATP + hydroxylamine + L-glutamate = ADP + L-glutamine hydroxamate + phosphate"}
{"X":47386,"RHEA_ID":45805,"compounds":"ATP + hydroxylamine + L-glutamate => ADP + L-glutamine hydroxamate + phosphate"}
{"X":47387,"RHEA_ID":45806,"compounds":"ADP + L-glutamine hydroxamate + phosphate => ATP + hydroxylamine + L-glutamate"}
{"X":47388,"RHEA_ID":49109,"DIRECTION":"LR","MASTER_ID":49108,"metacyc":"RXN-8799","compounds":"Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine => 3,8-divinyl protochlorophyllide a + 5'-deoxyadenosine + 2 H(+) + L-methionine"}
{"X":47389,"RHEA_ID":45808,"DIRECTION":"UN","MASTER_ID":45808,"ec":"4.2.1.158","compounds":"galactarate = (2S,3R)-dihydroxy-5-oxohexanedioate + H2O"}
{"X":47390,"RHEA_ID":45809,"compounds":"galactarate => (2S,3R)-dihydroxy-5-oxohexanedioate + H2O"}
{"X":47391,"RHEA_ID":45810,"compounds":"(2S,3R)-dihydroxy-5-oxohexanedioate + H2O => galactarate"}
{"X":47392,"RHEA_ID":55824,"compounds":"a 7(1),7(1)-dihydroxybacteriochlorophyllide d = a bacteriochlorophyllide f + H2O"}
{"X":47393,"RHEA_ID":45812,"DIRECTION":"UN","MASTER_ID":45812,"ec":"4.2.1.134","compounds":"a very-long-chain (3R)-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O"}
{"X":47394,"RHEA_ID":45813,"DIRECTION":"LR","MASTER_ID":45812,"metacyc":"RXN-11750","compounds":"a very-long-chain (3R)-hydroxyacyl-CoA => a very-long-chain (2E)-enoyl-CoA + H2O"}
{"X":47395,"RHEA_ID":49116,"DIRECTION":"UN","MASTER_ID":49116,"ec":"1.14.13.224","compounds":"H(+) + NADPH + O2 + protodeoxyviolaceinate = deoxyviolaceinate + H2O + NADP(+)"}
{"X":47396,"RHEA_ID":49117,"DIRECTION":"LR","MASTER_ID":49116,"metacyc":"RXN-13344","compounds":"H(+) + NADPH + O2 + protodeoxyviolaceinate => deoxyviolaceinate + H2O + NADP(+)"}
{"X":47397,"RHEA_ID":45816,"compounds":"(S)-lactate + A = AH2 + pyruvate"}
{"X":47398,"RHEA_ID":45817,"DIRECTION":"LR","MASTER_ID":45816,"ecocyc":"L-LACTDEHYDROGFMN-RXN","metacyc":"L-LACTDEHYDROGFMN-RXN","compounds":"(S)-lactate + A => AH2 + pyruvate"}
{"X":47399,"RHEA_ID":55830,"compounds":"6beta-hydroxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cortisol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":47400,"RHEA_ID":55832,"compounds":"cortisone + O2 + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxycortisone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47401,"RHEA_ID":55833,"compounds":"cortisone + O2 + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxycortisone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47402,"RHEA_ID":59178,"compounds":"AMP + H(+) + O-phospho-L-serine => ADP + L-serine"}
{"X":47403,"RHEA_ID":49124,"DIRECTION":"UN","MASTER_ID":49124,"ec":"1.14.13.217","compounds":"H(+) + NADPH + O2 + protodeoxyviolaceinate = H2O + NADP(+) + protoviolaceinate"}
{"X":47404,"RHEA_ID":55836,"compounds":"calcitriol + UDP-alpha-D-glucuronate = calcitriol 25-O-(beta-D-glucuronide) + H(+) + UDP"}
{"X":47405,"RHEA_ID":55837,"compounds":"calcitriol + UDP-alpha-D-glucuronate => calcitriol 25-O-(beta-D-glucuronide) + H(+) + UDP"}
{"X":47406,"RHEA_ID":45825,"DIRECTION":"LR","MASTER_ID":45824,"metacyc":"RXN-5641","compounds":"H(+) + L-serine => CO2 + ethanolamine"}
{"X":47407,"RHEA_ID":59183,"compounds":"5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O <=> 2 AMP + H(+)"}
{"X":47408,"RHEA_ID":45827,"compounds":"H(+) + L-serine <=> CO2 + ethanolamine"}
{"X":47409,"RHEA_ID":49130,"compounds":"5'-deoxyadenosine + A + 2 H(+) + L-methionine + N-acetyl-L-phosphinothricin + S-adenosyl-L-homocysteine => AH2 + N-acetyl-demethyl-L-phosphinothricin + 2 S-adenosyl-L-methionine"}
{"X":47410,"RHEA_ID":49131,"DIRECTION":"BI","MASTER_ID":49128,"metacyc":"RXN-17199","compounds":"AH2 + N-acetyl-demethyl-L-phosphinothricin + 2 S-adenosyl-L-methionine <=> 5'-deoxyadenosine + A + 2 H(+) + L-methionine + N-acetyl-L-phosphinothricin + S-adenosyl-L-homocysteine"}
{"X":47411,"RHEA_ID":59187,"compounds":"2,4-diacetylphloroglucinol + H2O <=> 2-acetylphloroglucinol + acetate"}
{"X":47412,"RHEA_ID":45831,"compounds":"(3R)-hydroxyhexanoyl-CoA + NAD(+) <=> 3-oxohexanoyl-CoA + H(+) + NADH"}
{"X":47413,"RHEA_ID":55845,"compounds":"calcidiol + UDP-alpha-D-glucuronate => calcidiol 3-O-(beta-D-glucuronide) + H(+) + UDP"}
{"X":47414,"RHEA_ID":45833,"compounds":"(3R)-hydroxydecanoyl-CoA + NAD(+) => 3-oxodecanoyl-CoA + H(+) + NADH"}
{"X":47415,"RHEA_ID":49136,"compounds":"H(+) + L-methionyl-[protein] + NADPH + O2 = H2O + L-methionyl-S-oxide-[protein] + NADP(+)"}
{"X":47416,"RHEA_ID":45835,"compounds":"(3R)-hydroxydecanoyl-CoA + NAD(+) <=> 3-oxodecanoyl-CoA + H(+) + NADH"}
{"X":47417,"RHEA_ID":55849,"compounds":"[(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA => [(2->6)-alpha-D-glucosyl-(1->4)-N,7-O-diacetyl-alpha-D-neuraminosyl](n) + n CoA"}
{"X":47418,"RHEA_ID":49139,"compounds":"H(+) + L-methionyl-[protein] + NADPH + O2 <=> H2O + L-methionyl-S-oxide-[protein] + NADP(+)"}
{"X":47419,"RHEA_ID":52522,"compounds":"20-hydroxy prostaglandin E1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + prostaglandin E1 + reduced [NADPH--hemoprotein reductase]"}
{"X":47420,"RHEA_ID":45839,"compounds":"1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-4-phosphate) + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}
{"X":47421,"RHEA_ID":55853,"compounds":"[(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA => [(2->6)-alpha-D-glucosyl-(1->4)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA"}
{"X":47422,"RHEA_ID":45841,"compounds":"(3R)-hydroxydecanoyl-CoA + NADP(+) => 3-oxodecanoyl-CoA + H(+) + NADPH"}
{"X":47423,"RHEA_ID":45842,"compounds":"3-oxodecanoyl-CoA + H(+) + NADPH => (3R)-hydroxydecanoyl-CoA + NADP(+)"}
{"X":47424,"RHEA_ID":45843,"compounds":"(3R)-hydroxydecanoyl-CoA + NADP(+) <=> 3-oxodecanoyl-CoA + H(+) + NADPH"}
{"X":47425,"RHEA_ID":45844,"compounds":"(3R)-hydroxyoctanoyl-CoA + NADP(+) = 3-oxooctanoyl-CoA + H(+) + NADPH"}
{"X":47426,"RHEA_ID":45845,"compounds":"(3R)-hydroxyoctanoyl-CoA + NADP(+) => 3-oxooctanoyl-CoA + H(+) + NADPH"}
{"X":47427,"RHEA_ID":45846,"compounds":"3-oxooctanoyl-CoA + H(+) + NADPH => (3R)-hydroxyoctanoyl-CoA + NADP(+)"}
{"X":47428,"RHEA_ID":45847,"compounds":"(3R)-hydroxyoctanoyl-CoA + NADP(+) <=> 3-oxooctanoyl-CoA + H(+) + NADPH"}
{"X":47429,"RHEA_ID":45848,"compounds":"(3R)-hydroxydodecanoyl-CoA + NADP(+) = 3-oxododecanoyl-CoA + H(+) + NADPH"}
{"X":47430,"RHEA_ID":45849,"compounds":"(3R)-hydroxydodecanoyl-CoA + NADP(+) => 3-oxododecanoyl-CoA + H(+) + NADPH"}
{"X":47431,"RHEA_ID":45850,"compounds":"3-oxododecanoyl-CoA + H(+) + NADPH => (3R)-hydroxydodecanoyl-CoA + NADP(+)"}
{"X":47432,"RHEA_ID":45851,"compounds":"(3R)-hydroxydodecanoyl-CoA + NADP(+) <=> 3-oxododecanoyl-CoA + H(+) + NADPH"}
{"X":47433,"RHEA_ID":55869,"DIRECTION":"LR","MASTER_ID":55868,"metacyc":"LACTATE-2-MONOOXYGENASE-RXN","compounds":"(S)-lactate + O2 => H2O2 + pyruvate"}
{"X":47434,"RHEA_ID":45853,"compounds":"Co(II)-factor III + H(+) + S-adenosyl-L-methionine => Co(II)-factor IV + S-adenosyl-L-homocysteine"}
{"X":47435,"RHEA_ID":45854,"compounds":"Co(II)-factor IV + S-adenosyl-L-homocysteine => Co(II)-factor III + H(+) + S-adenosyl-L-methionine"}
{"X":47436,"RHEA_ID":55872,"DIRECTION":"UN","MASTER_ID":55872,"ec":"1.7.1.17","compounds":"anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) = 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH"}
{"X":47437,"RHEA_ID":55873,"compounds":"anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) => 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH"}
{"X":47438,"RHEA_ID":45857,"compounds":"3-hydroxytetradecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(2-hydroxytridecyl)-pyran-2-one + 2 CO2 + 3 CoA"}
{"X":47439,"RHEA_ID":45858,"compounds":"4-hydroxy-6-(2-hydroxytridecyl)-pyran-2-one + 2 CO2 + 3 CoA => 3-hydroxytetradecanoyl-CoA + 2 H(+) + 2 malonyl-CoA"}
{"X":47440,"RHEA_ID":55876,"compounds":"apo-[aequorin] + coelenterazine = apo-[aequorin]--coelenterazine"}
{"X":47441,"RHEA_ID":55877,"DIRECTION":"LR","MASTER_ID":55876,"metacyc":"RXN-18861","compounds":"apo-[aequorin] + coelenterazine => apo-[aequorin]--coelenterazine"}
{"X":47442,"RHEA_ID":45861,"compounds":"12-hydroxyoctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(11-hydroxyheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA"}
{"X":47443,"RHEA_ID":45862,"compounds":"4-hydroxy-6-(11-hydroxyheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA => 12-hydroxyoctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA"}
{"X":47444,"RHEA_ID":55880,"compounds":"apo-[aequorin]--coelenterazine + O2 = [aequorin]"}
{"X":47445,"RHEA_ID":45864,"compounds":"16-hydroxyhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(15-hydroxypentadecyl)-pyran-2-one + 2 CO2 + 3 CoA"}
{"X":47446,"RHEA_ID":45865,"compounds":"16-hydroxyhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(15-hydroxypentadecyl)-pyran-2-one + 2 CO2 + 3 CoA"}
{"X":47447,"RHEA_ID":55883,"compounds":"apo-[aequorin]--coelenterazine + O2 <=> [aequorin]"}
{"X":47448,"RHEA_ID":59240,"DIRECTION":"UN","MASTER_ID":59240,"ec":"2.1.4.3","compounds":"L-arginine + L-lysine = L-homoarginine + L-ornithine"}
{"X":47449,"RHEA_ID":45868,"compounds":"9-decenoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(non-8-en-1-yl)-pyran-2-one + 2 CO2 + 3 CoA"}
{"X":47450,"RHEA_ID":59242,"compounds":"L-homoarginine + L-ornithine => L-arginine + L-lysine"}
{"X":47451,"RHEA_ID":59243,"compounds":"L-arginine + L-lysine <=> L-homoarginine + L-ornithine"}
{"X":47452,"RHEA_ID":55888,"compounds":"[aequorin]--dioxetanone = [excited state blue fluorescent protein] + CO2"}
{"X":47453,"RHEA_ID":45872,"compounds":"15-hydroxypentadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(14-hydroxytetradecyl)-pyran-2-one + 2 CO2 + 3 CoA"}
{"X":47454,"RHEA_ID":59246,"compounds":"acetate + ADP-D-ribose + H(+) => 3''-O-acetyl-ADP-D-ribose + H2O"}
{"X":47455,"RHEA_ID":49176,"DIRECTION":"UN","MASTER_ID":49176,"ec":"2.1.1.332","compounds":"12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine = 12-ethyl-8-isobutyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine"}
{"X":47456,"RHEA_ID":45875,"compounds":"15-hydroxypentadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(14-hydroxytetradecyl)-pyran-2-one + 2 CO2 + 3 CoA"}
{"X":47457,"RHEA_ID":45876,"compounds":"2-methylhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 6-(hexadecan-2-yl)-4-hydroxy-pyran-2-one + 2 CO2 + 3 CoA"}
{"X":47458,"RHEA_ID":45877,"compounds":"2-methylhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 6-(hexadecan-2-yl)-4-hydroxy-pyran-2-one + 2 CO2 + 3 CoA"}
{"X":47459,"RHEA_ID":49180,"DIRECTION":"UN","MASTER_ID":49180,"ec":"2.1.1.333","compounds":"a bacteriochlorophyllide d + S-adenosyl-L-methionine = a bacteriochlorophyllide c + H(+) + S-adenosyl-L-homocysteine"}
{"X":47460,"RHEA_ID":49181,"compounds":"a bacteriochlorophyllide d + S-adenosyl-L-methionine => a bacteriochlorophyllide c + H(+) + S-adenosyl-L-homocysteine"}
{"X":47461,"RHEA_ID":45880,"compounds":"3-methylundecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(2-methyldecyl)-pyran-2-one + 2 CO2 + 3 CoA"}
{"X":47462,"RHEA_ID":45881,"compounds":"3-methylundecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(2-methyldecyl)-pyran-2-one + 2 CO2 + 3 CoA"}
{"X":47463,"RHEA_ID":55898,"compounds":"5-chloro-L-tryptophan + FAD + 2 H2O => chloride + FADH2 + L-tryptophan + O2"}
{"X":47464,"RHEA_ID":49185,"DIRECTION":"LR","MASTER_ID":49184,"metacyc":"RXN-17429","compounds":"chlorophyllide a + H(+) + H2O => 8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + CO2 + methanol"}
{"X":47465,"RHEA_ID":45884,"compounds":"12-methyloctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(11-methylheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA"}
{"X":47466,"RHEA_ID":45885,"compounds":"12-methyloctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(11-methylheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA"}
{"X":47467,"RHEA_ID":49188,"DIRECTION":"UN","MASTER_ID":49188,"ec":"4.2.1.169","compounds":"a bacteriochlorophyllide d = a 3-vinylbacteriochlorophyllide d + H2O"}
{"X":47468,"RHEA_ID":55904,"DIRECTION":"UN","MASTER_ID":55904,"ec":"1.14.19.60","compounds":"7-chloro-L-tryptophan + chloride + FADH2 + O2 = 6,7-dichloro-L-tryptophan + FAD + 2 H2O"}
{"X":47469,"RHEA_ID":45888,"compounds":"12-methyltridecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(11-methyldodecyl)-pyran-2-one + 2 CO2 + 3 CoA"}
{"X":47470,"RHEA_ID":52574,"DIRECTION":"RL","MASTER_ID":52572,"metacyc":"RXN-12558","compounds":"(2E)-butenoyl-CoA + H(+) + NADH => butanoyl-CoA + NAD(+)"}
{"X":47471,"RHEA_ID":59264,"compounds":"Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O = Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + N-(2,3-dihydroxybenzoyl)-L-serine"}
{"X":47472,"RHEA_ID":45892,"DIRECTION":"UN","MASTER_ID":45892,"ec":"2.7.8.n3","compounds":"an N-acylsphing-4-enine + CDP-ethanolamine = CMP + H(+) + N-acylsphing-4-enine 1-phosphoethanolamine"}
{"X":47473,"RHEA_ID":45893,"compounds":"an N-acylsphing-4-enine + CDP-ethanolamine => CMP + H(+) + N-acylsphing-4-enine 1-phosphoethanolamine"}
{"X":47474,"RHEA_ID":59267,"compounds":"Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O <=> Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + N-(2,3-dihydroxybenzoyl)-L-serine"}
{"X":47475,"RHEA_ID":55924,"DIRECTION":"UN","MASTER_ID":55924,"ec":"1.14.14.73","compounds":"albendazole + O2 + reduced [NADPH--hemoprotein reductase] = albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47476,"RHEA_ID":45896,"DIRECTION":"UN","MASTER_ID":45896,"ec":"2.7.8.n3","compounds":"CDP-ethanolamine + N-acyl-sphingoid base = CMP + H(+) + N-(acyl)-sphingoid 1-phosphoethanolamine"}
{"X":47477,"RHEA_ID":45897,"compounds":"CDP-ethanolamine + N-acyl-sphingoid base => CMP + H(+) + N-(acyl)-sphingoid 1-phosphoethanolamine"}
{"X":47478,"RHEA_ID":49200,"DIRECTION":"UN","MASTER_ID":49200,"ec":"2.5.1.132","compounds":"D-mannose 6-phosphate + H2O + phosphoenolpyruvate = 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + phosphate"}
{"X":47479,"RHEA_ID":55928,"DIRECTION":"UN","MASTER_ID":55928,"ec":"1.14.14.73","compounds":"fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] = fenbendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47480,"RHEA_ID":45900,"DIRECTION":"UN","MASTER_ID":45900,"ec":"5.3.3.8","compounds":"a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA"}
{"X":47481,"RHEA_ID":45901,"compounds":"a (3Z)-enoyl-CoA => a 4-saturated (2E)-enoyl-CoA"}
{"X":47482,"RHEA_ID":55930,"compounds":"fenbendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => fenbendazole + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":47483,"RHEA_ID":55932,"compounds":"3-O-(5'-adenylyl)-L-threonyl-[protein] + H2O = AMP + H(+) + L-threonyl-[protein]"}
{"X":47484,"RHEA_ID":45904,"compounds":"devancoaminyl-vancomycin + dTDP-beta-L-vancosamine = dTDP + epivancomycin + H(+)"}
{"X":47485,"RHEA_ID":45905,"compounds":"devancoaminyl-vancomycin + dTDP-beta-L-vancosamine => dTDP + epivancomycin + H(+)"}
{"X":47486,"RHEA_ID":55935,"compounds":"3-O-(5'-adenylyl)-L-threonyl-[protein] + H2O <=> AMP + H(+) + L-threonyl-[protein]"}
{"X":47487,"RHEA_ID":49209,"compounds":"20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 20S,24S-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]"}
{"X":47488,"RHEA_ID":45908,"compounds":"chloroorienticin B + dTDP-beta-L-vancosamine = chloroeremomycin + dTDP + H(+)"}
{"X":47489,"RHEA_ID":45909,"compounds":"chloroorienticin B + dTDP-beta-L-vancosamine => chloroeremomycin + dTDP + H(+)"}
{"X":47490,"RHEA_ID":49212,"compounds":"20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 20S,25-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]"}
{"X":47491,"RHEA_ID":55940,"compounds":"all-trans-3,4-didehydroretinol + NAD(+) = all-trans-3,4-didehydroretinal + H(+) + NADH"}
{"X":47492,"RHEA_ID":45912,"compounds":"a (2E,4E)-dienoyl-CoA + H(+) + NADPH = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)"}
{"X":47493,"RHEA_ID":45913,"DIRECTION":"LR","MASTER_ID":45912,"metacyc":"RXN-7911","compounds":"a (2E,4E)-dienoyl-CoA + H(+) + NADPH => a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)"}
{"X":47494,"RHEA_ID":49216,"DIRECTION":"UN","MASTER_ID":49216,"ec":"3.1.3.103","compounds":"3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + H2O = 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + phosphate"}
{"X":47495,"RHEA_ID":55944,"compounds":"2-chloroethanol + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + chloroacetaldehyde + 2 H(+)"}
{"X":47496,"RHEA_ID":45916,"compounds":"12-hydroxyoctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(13-hydroxy-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA"}
{"X":47497,"RHEA_ID":45917,"compounds":"12-hydroxyoctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(13-hydroxy-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA"}
{"X":47498,"RHEA_ID":59291,"compounds":"beta-D-glucosyl-(1<->1)-sphing-4-enine + H2O <=> D-glucose + sphing-4-enine"}
{"X":47499,"RHEA_ID":55948,"compounds":"A + D-alanine + H2O = AH2 + NH4(+) + pyruvate"}
{"X":47500,"RHEA_ID":45920,"compounds":"16-hydroxyhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(17-hydroxy-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA"}
{"X":47501,"RHEA_ID":59294,"compounds":"D-galactose + N-octadecanoylsphing-4-enine => beta-D-galactosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O"}
{"X":47502,"RHEA_ID":59295,"compounds":"beta-D-galactosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O <=> D-galactose + N-octadecanoylsphing-4-enine"}
{"X":47503,"RHEA_ID":45923,"compounds":"16-hydroxyhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(17-hydroxy-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA"}
{"X":47504,"RHEA_ID":45924,"compounds":"9-decenoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(2-oxoundec-10-en-1-yl)pyran-2-one + 3 CO2 + 4 CoA"}
{"X":47505,"RHEA_ID":45925,"compounds":"9-decenoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(2-oxoundec-10-en-1-yl)pyran-2-one + 3 CO2 + 4 CoA"}
{"X":47506,"RHEA_ID":59299,"compounds":"an N-acylglycine + 2 L-ascorbate + O2 <=> an N-acyl-(2S)-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical"}
{"X":47507,"RHEA_ID":45927,"compounds":"9-decenoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(2-oxoundec-10-en-1-yl)pyran-2-one + 3 CO2 + 4 CoA"}
{"X":47508,"RHEA_ID":55957,"compounds":"(9Z)-octadecenoate + AH2 + O2 => (12R)-hydroxy-(9Z)-octadecenoate + A + H2O"}
{"X":47509,"RHEA_ID":45929,"compounds":"15-hydroxypentadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(16-hydroxy-2-oxohexadecyl)pyran-2-one + 3 CO2 + 4 CoA"}
{"X":47510,"RHEA_ID":55959,"compounds":"(9Z)-octadecenoate + AH2 + O2 <=> (12R)-hydroxy-(9Z)-octadecenoate + A + H2O"}
{"X":47511,"RHEA_ID":45931,"compounds":"15-hydroxypentadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(16-hydroxy-2-oxohexadecyl)pyran-2-one + 3 CO2 + 4 CoA"}
{"X":47512,"RHEA_ID":45932,"compounds":"2-methylhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(3-methyl-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA"}
{"X":47513,"RHEA_ID":45933,"compounds":"2-methylhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(3-methyl-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA"}
{"X":47514,"RHEA_ID":49236,"DIRECTION":"UN","MASTER_ID":49236,"ec":"2.7.1.211","compounds":"N(pros)-phospho-L-histidyl-[protein](out) + sucrose = L-histidyl-[protein] + sucrose 6(G)-phosphate(in)"}
{"X":47515,"RHEA_ID":45935,"compounds":"2-methylhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(3-methyl-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA"}
{"X":47516,"RHEA_ID":45936,"compounds":"3-methylundecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(4-methyl-2-oxododecyl)pyran-2-one + 3 CO2 + 4 CoA"}
{"X":47517,"RHEA_ID":45937,"compounds":"3-methylundecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(4-methyl-2-oxododecyl)pyran-2-one + 3 CO2 + 4 CoA"}
{"X":47518,"RHEA_ID":49240,"DIRECTION":"UN","MASTER_ID":49240,"ec":"2.7.1.193","compounds":"N(pros)-phospho-L-histidyl-[protein] + N-acetyl-D-glucosamine(out) = L-histidyl-[protein] + N-acetyl-D-glucosamine 6-phosphate(in)"}
{"X":47519,"RHEA_ID":45939,"compounds":"3-methylundecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(4-methyl-2-oxododecyl)pyran-2-one + 3 CO2 + 4 CoA"}
{"X":47520,"RHEA_ID":55969,"DIRECTION":"LR","MASTER_ID":55968,"metacyc":"RXN-18974","compounds":"(+)-kolavelool + S-adenosyl-L-methionine => (+)-O-methylkolavelool + H(+) + S-adenosyl-L-homocysteine"}
{"X":47521,"RHEA_ID":59314,"compounds":"D-galactono-1,5-lactone + H2O2 => D-galactose + O2"}
{"X":47522,"RHEA_ID":49244,"compounds":"NAD(+) + resolvin E1 = 18-oxo-resolvin E1 + H(+) + NADH"}
{"X":47523,"RHEA_ID":45943,"compounds":"12-methyloctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(13-methyl-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA"}
{"X":47524,"RHEA_ID":45944,"compounds":"12-methyltridecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(13-methyl-2-oxotetradecyl)pyran-2-one + 3 CO2 + 4 CoA"}
{"X":47525,"RHEA_ID":45945,"compounds":"12-methyltridecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(13-methyl-2-oxotetradecyl)pyran-2-one + 3 CO2 + 4 CoA"}
{"X":47526,"RHEA_ID":49248,"DIRECTION":"UN","MASTER_ID":49248,"ec":"2.7.1.200","compounds":"galactitol(out) + N(pros)-phospho-L-histidyl-[protein] = galactitol 1-phosphate(in) + L-histidyl-[protein]"}
{"X":47527,"RHEA_ID":55976,"compounds":"glutathione + thiosulfate = H(+) + S-sulfanylglutathione + sulfite"}
{"X":47528,"RHEA_ID":45948,"DIRECTION":"UN","MASTER_ID":45948,"ec":"2.3.1.48","compounds":"acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]"}
{"X":47529,"RHEA_ID":55978,"compounds":"H(+) + S-sulfanylglutathione + sulfite => glutathione + thiosulfate"}
{"X":47530,"RHEA_ID":49252,"DIRECTION":"UN","MASTER_ID":49252,"ec":"2.7.1.202","compounds":"D-fructose(out) + N(pros)-phospho-L-histidyl-[protein] = D-fructose 1-phosphate(in) + L-histidyl-[protein]"}
{"X":47531,"RHEA_ID":45951,"compounds":"acetyl-CoA + L-lysyl-[protein] <=> CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]"}
{"X":47532,"RHEA_ID":45952,"compounds":"L-asparaginyl-[protein] + UDP-alpha-D-glucose = H(+) + N(4)-(beta-D-glucosyl)-L-asparaginyl-[protein] + UDP"}
{"X":47533,"RHEA_ID":45953,"compounds":"L-asparaginyl-[protein] + UDP-alpha-D-glucose => H(+) + N(4)-(beta-D-glucosyl)-L-asparaginyl-[protein] + UDP"}
{"X":47534,"RHEA_ID":45954,"compounds":"H(+) + N(4)-(beta-D-glucosyl)-L-asparaginyl-[protein] + UDP => L-asparaginyl-[protein] + UDP-alpha-D-glucose"}
{"X":47535,"RHEA_ID":59328,"DIRECTION":"UN","MASTER_ID":59328,"ec":"3.1.1.110","compounds":"D-xylono-1,5-lactone + H2O = D-xylonate + H(+)"}
{"X":47536,"RHEA_ID":45956,"compounds":"(9Z)-octadecenoyl-CoA(in) = (9Z)-octadecenoyl-CoA(out)"}
{"X":47537,"RHEA_ID":45957,"compounds":"(9Z)-octadecenoyl-CoA(in) => (9Z)-octadecenoyl-CoA(out)"}
{"X":47538,"RHEA_ID":45958,"compounds":"(9Z)-octadecenoyl-CoA(out) => (9Z)-octadecenoyl-CoA(in)"}
{"X":47539,"RHEA_ID":59332,"compounds":"1'-hydroxy-gamma-carotene + A = 1'-hydroxytorulene + AH2"}
{"X":47540,"RHEA_ID":45960,"compounds":"24,25-dihydrolanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}
{"X":47541,"RHEA_ID":45961,"compounds":"24,25-dihydrolanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}
{"X":47542,"RHEA_ID":49263,"compounds":"D-galactose(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-galactose 6-phosphate(in) + L-histidyl-[protein]"}
{"X":47543,"RHEA_ID":55992,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)"}
{"X":47544,"RHEA_ID":45964,"compounds":"5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 H2O = 2 AMP + ATP + 2 H(+)"}
{"X":47545,"RHEA_ID":55994,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP"}
{"X":47546,"RHEA_ID":49267,"compounds":"5-O-[(E)-caffeoyl]-shikimate + H2O <=> (E)-caffeate + H(+) + shikimate"}
{"X":47547,"RHEA_ID":59340,"compounds":"1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene + A = 1'-hydroxy-demethylspheroidene + AH2"}
{"X":47548,"RHEA_ID":45968,"compounds":"androst-4-ene-3,17-dione + H(+) + NADH + O2 = 9alpha-hydroxy-androst-4-ene-3,17-dione + H2O + NAD(+)"}
{"X":47549,"RHEA_ID":55998,"compounds":"beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] => H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein]"}
{"X":47550,"RHEA_ID":45970,"compounds":"9alpha-hydroxy-androst-4-ene-3,17-dione + H2O + NAD(+) => androst-4-ene-3,17-dione + H(+) + NADH + O2"}
{"X":47551,"RHEA_ID":59344,"DIRECTION":"UN","MASTER_ID":59344,"ec":"1.1.3.5","compounds":"D-maltose + O2 = D-maltobiono-1,5-lactone + H2O2"}
{"X":47552,"RHEA_ID":45972,"compounds":"3-oxochol-4-en-22-oate + H(+) + NADH + O2 = 9alpha-hydroxy-3-oxochol-4-en-22-oate + H2O + NAD(+)"}
{"X":47553,"RHEA_ID":56002,"compounds":"beta-D-glucose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) => H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein]"}
{"X":47554,"RHEA_ID":49275,"compounds":"alfacalcidol + O2 + reduced [NADPH--hemoprotein reductase] <=> calcitriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47555,"RHEA_ID":59348,"compounds":"D-maltobiono-1,5-lactone + H2O = D-maltobionate + H(+)"}
{"X":47556,"RHEA_ID":45976,"compounds":"3-oxochola-1,4-dien-22-oate + H(+) + NADH + O2 = 9alpha-hydroxy-3-oxochola-1,4-dien-22-oate + H2O + NAD(+)"}
{"X":47557,"RHEA_ID":45977,"compounds":"3-oxochola-1,4-dien-22-oate + H(+) + NADH + O2 => 9alpha-hydroxy-3-oxochola-1,4-dien-22-oate + H2O + NAD(+)"}
{"X":47558,"RHEA_ID":45978,"compounds":"9alpha-hydroxy-3-oxochola-1,4-dien-22-oate + H2O + NAD(+) => 3-oxochola-1,4-dien-22-oate + H(+) + NADH + O2"}
{"X":47559,"RHEA_ID":59352,"DIRECTION":"UN","MASTER_ID":59352,"ec":"1.1.3.5","compounds":"beta-lactose + O2 = H2O2 + lactobiono-1,5-lactone"}
{"X":47560,"RHEA_ID":56009,"DIRECTION":"LR","MASTER_ID":56008,"metacyc":"RXN-18911","compounds":"4 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) => 4 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)"}
{"X":47561,"RHEA_ID":56010,"compounds":"4 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) => 4 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3)"}
{"X":47562,"RHEA_ID":59355,"compounds":"beta-lactose + O2 <=> H2O2 + lactobiono-1,5-lactone"}
{"X":47563,"RHEA_ID":56012,"compounds":"H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) = beta-D-mannose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)"}
{"X":47564,"RHEA_ID":56013,"DIRECTION":"LR","MASTER_ID":56012,"metacyc":"RXN-18922","compounds":"H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) => beta-D-mannose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)"}
{"X":47565,"RHEA_ID":56014,"compounds":"beta-D-mannose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3)"}
{"X":47566,"RHEA_ID":45986,"compounds":"9alpha-hydroxy-3-oxochola-1,4-dien-22-oyl-CoA + H2O + NAD(+) => 3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH + O2"}
{"X":47567,"RHEA_ID":59360,"DIRECTION":"UN","MASTER_ID":59360,"ec":"3.4.13.20","compounds":"carnosine + H2O = beta-alanine + L-histidine"}
{"X":47568,"RHEA_ID":56017,"DIRECTION":"LR","MASTER_ID":56016,"metacyc":"RXN-18919","compounds":"H2O + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2) => beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2)"}
{"X":47569,"RHEA_ID":45989,"compounds":"3,17-dihydroxy-9,10-seconandrost-1,3,5(10)-triene-9-one + FMNH2 + O2 => 3,4,17-trihydroxy-9,10-seconandrost-1,3,5(10)-triene-9-one + FMN + H(+) + H2O"}
{"X":47570,"RHEA_ID":45990,"compounds":"3,4,17-trihydroxy-9,10-seconandrost-1,3,5(10)-triene-9-one + FMN + H(+) + H2O => 3,17-dihydroxy-9,10-seconandrost-1,3,5(10)-triene-9-one + FMNH2 + O2"}
{"X":47571,"RHEA_ID":45991,"compounds":"3,17-dihydroxy-9,10-seconandrost-1,3,5(10)-triene-9-one + FMNH2 + O2 <=> 3,4,17-trihydroxy-9,10-seconandrost-1,3,5(10)-triene-9-one + FMN + H(+) + H2O"}
{"X":47572,"RHEA_ID":56021,"DIRECTION":"LR","MASTER_ID":56020,"metacyc":"RXN-18920","compounds":"H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2) => beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2)"}
{"X":47573,"RHEA_ID":56022,"compounds":"beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2)"}
{"X":47574,"RHEA_ID":45994,"compounds":"(2E)-decenoyl-CoA + H2O => (3R)-hydroxydecanoyl-CoA"}
{"X":47575,"RHEA_ID":56024,"compounds":"H2O + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2) = beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)"}
{"X":47576,"RHEA_ID":56025,"DIRECTION":"LR","MASTER_ID":56024,"metacyc":"RXN-18921","compounds":"H2O + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2) => beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)"}
{"X":47577,"RHEA_ID":56026,"compounds":"beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) => H2O + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2)"}
{"X":47578,"RHEA_ID":45998,"compounds":"a 2-oxocarboxylate + a quinol + NH4(+) => a D-alpha-amino acid + a quinone + H2O"}
{"X":47579,"RHEA_ID":46000,"compounds":"adenosine + H(+) + tuberculosinyl diphosphate = 1-tuberculosinyladenosine + diphosphate"}
{"X":47580,"RHEA_ID":56030,"compounds":"3 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) => 3 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3)"}
{"X":47581,"RHEA_ID":46002,"compounds":"1-tuberculosinyladenosine + diphosphate => adenosine + H(+) + tuberculosinyl diphosphate"}
{"X":47582,"RHEA_ID":46003,"compounds":"adenosine + H(+) + tuberculosinyl diphosphate <=> 1-tuberculosinyladenosine + diphosphate"}
{"X":47583,"RHEA_ID":56033,"DIRECTION":"LR","MASTER_ID":56032,"metacyc":"RXN-18926","compounds":"H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) => beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1)"}
{"X":47584,"RHEA_ID":56034,"compounds":"beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3)"}
{"X":47585,"RHEA_ID":46006,"compounds":"2-methylpropanoyl-CoA + H(+) + NADH => 2-methylpropanal + CoA + NAD(+)"}
{"X":47586,"RHEA_ID":46007,"compounds":"2-methylpropanal + CoA + NAD(+) <=> 2-methylpropanoyl-CoA + H(+) + NADH"}
{"X":47587,"RHEA_ID":46008,"compounds":"CoA + NAD(+) + pentanal = H(+) + NADH + pentanoyl-CoA"}
{"X":47588,"RHEA_ID":56038,"compounds":"beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1)"}
{"X":47589,"RHEA_ID":46010,"compounds":"H(+) + NADH + pentanoyl-CoA => CoA + NAD(+) + pentanal"}
{"X":47590,"RHEA_ID":52693,"compounds":"3-phenyllactate + NADP(+) => 3-phenylpyruvate + H(+) + NADPH"}
{"X":47591,"RHEA_ID":56041,"DIRECTION":"LR","MASTER_ID":56040,"metacyc":"RXN-18918","compounds":"H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3) => beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)"}
{"X":47592,"RHEA_ID":46013,"DIRECTION":"LR","MASTER_ID":46012,"ecocyc":"MALATE-DEHYDROGENASE-ACCEPTOR-RXN","metacyc":"MALATE-DEHYDROGENASE-ACCEPTOR-RXN","compounds":"(S)-malate + a quinone => a quinol + oxaloacetate"}
{"X":47593,"RHEA_ID":46014,"compounds":"a quinol + oxaloacetate => (S)-malate + a quinone"}
{"X":47594,"RHEA_ID":59387,"DIRECTION":"BI","MASTER_ID":59384,"metacyc":"RXN-20194","compounds":"2-oxoglutarate + 4-amino-L-phenylalanine <=> 3-(4-aminophenyl)pyruvate + L-glutamate"}
{"X":47595,"RHEA_ID":56045,"DIRECTION":"LR","MASTER_ID":56044,"metacyc":"RXN-18916","compounds":"H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) => beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B3)"}
{"X":47596,"RHEA_ID":56046,"compounds":"beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B3) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3)"}
{"X":47597,"RHEA_ID":46018,"compounds":"H(+) + NADH + progesterone => (20R)-20-hydroxypregn-4-en-3-one + NAD(+)"}
{"X":47598,"RHEA_ID":56048,"DIRECTION":"UN","MASTER_ID":56048,"ec":"2.4.1.170","compounds":"daidzein + UDP-alpha-D-glucose = daidzein 7-O-beta-D-glucoside + UDP"}
{"X":47599,"RHEA_ID":46020,"DIRECTION":"UN","MASTER_ID":46020,"ec":"2.7.11.33","compounds":"[pyruvate, water dikinase] + ADP = [pyruvate, water dikinase]-phosphate + AMP + H(+)"}
{"X":47600,"RHEA_ID":56050,"compounds":"daidzein 7-O-beta-D-glucoside + UDP => daidzein + UDP-alpha-D-glucose"}
{"X":47601,"RHEA_ID":46022,"compounds":"[pyruvate, water dikinase]-phosphate + AMP + H(+) => [pyruvate, water dikinase] + ADP"}
{"X":47602,"RHEA_ID":56052,"DIRECTION":"UN","MASTER_ID":56052,"ec":"3.2.1.114","compounds":"2 H2O + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = 2 alpha-D-mannopyranose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]"}
{"X":47603,"RHEA_ID":46024,"DIRECTION":"UN","MASTER_ID":46024,"ec":"1.11.2.4","compounds":"H2O2 + tetradecanoate = (3R)-hydroxytetradecanoate + H2O"}
{"X":47604,"RHEA_ID":56054,"compounds":"2 alpha-D-mannopyranose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => 2 H2O + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]"}
{"X":47605,"RHEA_ID":46026,"compounds":"(3R)-hydroxytetradecanoate + H2O => H2O2 + tetradecanoate"}
{"X":47606,"RHEA_ID":46027,"compounds":"H2O2 + tetradecanoate <=> (3R)-hydroxytetradecanoate + H2O"}
{"X":47607,"RHEA_ID":49329,"DIRECTION":"LR","MASTER_ID":49328,"metacyc":"RXN-15623","compounds":"2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spheroidene => 2-hydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":47608,"RHEA_ID":56058,"compounds":"genistein 7-O-beta-D-glucoside + H(+) + UDP => genistein + UDP-alpha-D-glucose"}
{"X":47609,"RHEA_ID":46030,"compounds":"(2R)-hydroxytetradecanoate + H2O => H2O2 + tetradecanoate"}
{"X":47610,"RHEA_ID":46031,"compounds":"H2O2 + tetradecanoate <=> (2R)-hydroxytetradecanoate + H2O"}
{"X":47611,"RHEA_ID":46032,"DIRECTION":"UN","MASTER_ID":46032,"ec":"1.11.2.4","compounds":"H2O2 + tetradecanoate = (2S)-hydroxytetradecanoate + H2O"}
{"X":47612,"RHEA_ID":56062,"compounds":"CO2 + pentadecane => H(+) + hexadecanoate + hnu"}
{"X":47613,"RHEA_ID":46034,"compounds":"(2S)-hydroxytetradecanoate + H2O => H2O2 + tetradecanoate"}
{"X":47614,"RHEA_ID":46035,"compounds":"H2O2 + tetradecanoate <=> (2S)-hydroxytetradecanoate + H2O"}
{"X":47615,"RHEA_ID":56064,"DIRECTION":"UN","MASTER_ID":56064,"ec":"2.4.2.42","metacyc":"RXN-11242","compounds":"3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP"}
{"X":47616,"RHEA_ID":56065,"compounds":"3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose => 3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP"}
{"X":47617,"RHEA_ID":46038,"compounds":"dCMP + H(+) + UDP => 2'-deoxycytidine + UTP"}
{"X":47618,"RHEA_ID":46039,"DIRECTION":"BI","MASTER_ID":46036,"metacyc":"RXN-14100","compounds":"2'-deoxycytidine + UTP <=> dCMP + H(+) + UDP"}
{"X":47619,"RHEA_ID":56068,"compounds":"an N-acetyl-alpha-D-glucosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl derivative + H(+) + UDP"}
{"X":47620,"RHEA_ID":56069,"compounds":"an N-acetyl-alpha-D-glucosaminyl derivative + UDP-alpha-D-galactose => a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl derivative + H(+) + UDP"}
{"X":47621,"RHEA_ID":56070,"compounds":"a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl derivative + H(+) + UDP => an N-acetyl-alpha-D-glucosaminyl derivative + UDP-alpha-D-galactose"}
{"X":47622,"RHEA_ID":49344,"compounds":"2-hydroxyspirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2,2-dihydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":47623,"RHEA_ID":56072,"DIRECTION":"UN","MASTER_ID":56072,"ec":"2.4.1.358","compounds":"a 2-acylphloroglucinol + UDP-alpha-D-glucose = a 2-acylphloroglucinol 1-O-beta-D-glucoside + UDP"}
{"X":47624,"RHEA_ID":56073,"DIRECTION":"LR","MASTER_ID":56072,"metacyc":"RXN-18606","compounds":"a 2-acylphloroglucinol + UDP-alpha-D-glucose => a 2-acylphloroglucinol 1-O-beta-D-glucoside + UDP"}
{"X":47625,"RHEA_ID":46045,"DIRECTION":"LR","MASTER_ID":46044,"reactome":"R-HSA-6809808.2","compounds":"(3Z)-octenoyl-CoA => (2E)-octenoyl-CoA"}
{"X":47626,"RHEA_ID":49348,"compounds":"2,2-dihydroxyspirilloxanthin = 2-oxospirilloxanthin + H2O"}
{"X":47627,"RHEA_ID":46047,"compounds":"(3Z)-octenoyl-CoA <=> (2E)-octenoyl-CoA"}
{"X":47628,"RHEA_ID":56077,"DIRECTION":"LR","MASTER_ID":56076,"metacyc":"RXN-18254","compounds":"an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)"}
{"X":47629,"RHEA_ID":56078,"compounds":"an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+) => an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose"}
{"X":47630,"RHEA_ID":46050,"compounds":"alpha-D-galactosamine 1-phosphate => D-galactosamine 6-phosphate"}
{"X":47631,"RHEA_ID":46051,"DIRECTION":"BI","MASTER_ID":46048,"metacyc":"RXN-19879","compounds":"D-galactosamine 6-phosphate <=> alpha-D-galactosamine 1-phosphate"}
{"X":47632,"RHEA_ID":46052,"compounds":"U6 RNA 3'-terminal UU = U6 RNA 3'-terminal uridine 2',3'-cyclic phosphate + uridine"}
{"X":47633,"RHEA_ID":56082,"compounds":"[Rab1 protein]-O-phosphocholine-L-serine + CMP + H(+) => [Rab1 protein]-L-serine + CDP-choline"}
{"X":47634,"RHEA_ID":56083,"compounds":"[Rab1 protein]-L-serine + CDP-choline <=> [Rab1 protein]-O-phosphocholine-L-serine + CMP + H(+)"}
{"X":47635,"RHEA_ID":46055,"compounds":"U6 RNA 3'-terminal UU <=> U6 RNA 3'-terminal uridine 2',3'-cyclic phosphate + uridine"}
{"X":47636,"RHEA_ID":46056,"compounds":"(11E)-octadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (11E,13Z)-octadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":47637,"RHEA_ID":56086,"compounds":"[Rab1 protein]-L-serine + H(+) + phosphocholine => [Rab1 protein]-O-phosphocholine-L-serine + H2O"}
{"X":47638,"RHEA_ID":46058,"compounds":"(11E,13Z)-octadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => (11E)-octadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}
{"X":47639,"RHEA_ID":46059,"compounds":"(11E)-octadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> (11E,13Z)-octadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":47640,"RHEA_ID":46060,"compounds":"(11E)-octadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (5Z,11E)-octadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":47641,"RHEA_ID":49363,"compounds":"2',2'-dihydroxy-2-oxospirilloxanthin <=> 2,2'-dioxospirilloxanthin + H2O"}
{"X":47642,"RHEA_ID":46062,"compounds":"(5Z,11E)-octadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => (11E)-octadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}
{"X":47643,"RHEA_ID":49365,"DIRECTION":"LR","MASTER_ID":49364,"metacyc":"RXN-17213","compounds":"17-(4-hydroxyphenyl)heptadecanoate + ATP + H(+) => 17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + diphosphate"}
{"X":47644,"RHEA_ID":46064,"compounds":"(11E)-octadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (6Z,11E)-octadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":47645,"RHEA_ID":56094,"compounds":"biliverdin IXalpha + reduced coenzyme F420-(gamma-Glu)(n) => bilirubin IXalpha + H(+) + oxidized coenzyme F420-(gamma-Glu)(n)"}
{"X":47646,"RHEA_ID":46066,"compounds":"(6Z,11E)-octadecadienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => (11E)-octadecenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}
{"X":47647,"RHEA_ID":49369,"DIRECTION":"LR","MASTER_ID":49368,"metacyc":"RXN-17238","compounds":"19-(4-hydroxyphenyl)nonadecanoate + ATP + H(+) => 19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + diphosphate"}
{"X":47648,"RHEA_ID":46068,"compounds":"(3E)-nonenoyl-CoA = (2E)-nonenoyl-CoA"}
{"X":47649,"RHEA_ID":46069,"compounds":"(3E)-nonenoyl-CoA => (2E)-nonenoyl-CoA"}
{"X":47650,"RHEA_ID":56099,"compounds":"[protein]-C-terminal Gly-Gly + ATP + H(+) <=> [protein]-C-terminal Gly-Gly-AMP + diphosphate"}
{"X":47651,"RHEA_ID":46071,"compounds":"(3E)-nonenoyl-CoA <=> (2E)-nonenoyl-CoA"}
{"X":47652,"RHEA_ID":46072,"compounds":"(2E)-hexadecenoyl-CoA + H(+) + NADH = hexadecanoyl-CoA + NAD(+)"}
{"X":47653,"RHEA_ID":59454,"compounds":"a long-chain fatty aldehyde + H(+) + NADPH => a long-chain primary fatty alcohol + NADP(+)"}
{"X":47654,"RHEA_ID":49377,"compounds":"12-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 12,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47655,"RHEA_ID":46076,"compounds":"(2E)-eicosenoyl-CoA + H(+) + NADH = eicosanoyl-CoA + NAD(+)"}
{"X":47656,"RHEA_ID":49379,"compounds":"12-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 12,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47657,"RHEA_ID":46078,"compounds":"eicosanoyl-CoA + NAD(+) => (2E)-eicosenoyl-CoA + H(+) + NADH"}
{"X":47658,"RHEA_ID":59460,"compounds":"hexadecan-1-ol + NADP(+) = H(+) + hexadecanal + NADPH"}
{"X":47659,"RHEA_ID":46080,"compounds":"(2E)-tetracosenoyl-CoA + H(+) + NADH = NAD(+) + tetracosanoyl-CoA"}
{"X":47660,"RHEA_ID":49383,"compounds":"5-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 5,20-dihydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47661,"RHEA_ID":49384,"compounds":"(12R)-hydroxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = (12R),18-dihydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47662,"RHEA_ID":49385,"compounds":"(12R)-hydroxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] => (12R),18-dihydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47663,"RHEA_ID":46084,"DIRECTION":"UN","MASTER_ID":46084,"ec":"3.1.3.21","compounds":"H2O + sn-glycerol 1-phosphate = glycerol + phosphate"}
{"X":47664,"RHEA_ID":49387,"compounds":"(12R)-hydroxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (12R),18-dihydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47665,"RHEA_ID":56115,"compounds":"2-all-trans-nonaprenylphenol + H(+) + NADPH + O2 <=> 3-(all-trans-nonaprenyl)benzene-1,2-diol + H2O + NADP(+)"}
{"X":47666,"RHEA_ID":49389,"DIRECTION":"LR","MASTER_ID":49388,"metacyc":"RXN-9148","compounds":"UDP-alpha-D-glucose + validoxylamine A => H(+) + UDP + validamycin A"}
{"X":47667,"RHEA_ID":46092,"compounds":"(25R)-cholest-5-ene-3beta,26-diol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta-hydroxy-5-cholesten-26-al + 2 H2O + 2 oxidized [adrenodoxin]"}
{"X":47668,"RHEA_ID":46093,"compounds":"(25R)-cholest-5-ene-3beta,26-diol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta-hydroxy-5-cholesten-26-al + 2 H2O + 2 oxidized [adrenodoxin]"}
{"X":47669,"RHEA_ID":46094,"compounds":"(25R)-3beta-hydroxy-5-cholesten-26-al + 2 H2O + 2 oxidized [adrenodoxin] => (25R)-cholest-5-ene-3beta,26-diol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}
{"X":47670,"RHEA_ID":49393,"compounds":"20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 20S,23,24-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]"}
{"X":47671,"RHEA_ID":46096,"compounds":"3-phenylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4 CO2 + 4 CoA + dihydropinosylvin"}
{"X":47672,"RHEA_ID":46097,"DIRECTION":"LR","MASTER_ID":46096,"metacyc":"RXN-7611","compounds":"3-phenylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4 CO2 + 4 CoA + dihydropinosylvin"}
{"X":47673,"RHEA_ID":46098,"compounds":"4 CO2 + 4 CoA + dihydropinosylvin => 3-phenylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA"}
{"X":47674,"RHEA_ID":59476,"compounds":"2 AH2 + 2 ATP + benzoate + L-phenylalanine = 2 A + 2 AMP + 2 diphosphate + H(+) + N-benzoyl-L-phenylalaninol"}
{"X":47675,"RHEA_ID":46100,"compounds":"11-deoxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = cortisol + H2O + 2 oxidized [adrenodoxin]"}
{"X":47676,"RHEA_ID":49399,"compounds":"20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 20S,23,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]"}
{"X":47677,"RHEA_ID":46102,"compounds":"cortisol + H2O + 2 oxidized [adrenodoxin] => 11-deoxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}
{"X":47678,"RHEA_ID":49401,"DIRECTION":"LR","MASTER_ID":49400,"metacyc":"RXN-17380","compounds":"H2O + validoxylamine A 7'-phosphate => phosphate + validoxylamine A"}
{"X":47679,"RHEA_ID":46104,"compounds":"21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] = corticosterone + H2O + 2 oxidized [adrenodoxin]"}
{"X":47680,"RHEA_ID":49403,"compounds":"H2O + validoxylamine A 7'-phosphate <=> phosphate + validoxylamine A"}
{"X":47681,"RHEA_ID":56131,"compounds":"A + dimethylallyl diphosphate + H2O + nonaflavuxanthin <=> AH2 + diphosphate + flavuxanthin"}
{"X":47682,"RHEA_ID":46107,"compounds":"21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> corticosterone + H2O + 2 oxidized [adrenodoxin]"}
{"X":47683,"RHEA_ID":46108,"compounds":"(2E,6E,10E)-geranylgeraniol + H(+) + 2 NADPH + 2 O2 = (2E,6E,10E)-geranylgeranate + 3 H2O + 2 NADP(+)"}
{"X":47684,"RHEA_ID":59490,"compounds":"ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol => ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol"}
{"X":47685,"RHEA_ID":56135,"compounds":"(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine in DNA <=> a thymidine dimer in DNA"}
{"X":47686,"RHEA_ID":49409,"compounds":"[(1->2)-beta-D-mannosyl](n) + phosphate => [(1->2)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate"}
{"X":47687,"RHEA_ID":46112,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine"}
{"X":47688,"RHEA_ID":59494,"compounds":"3-geranyl-2S,3R-dihydro-N-cyclo-L-tryptophyl-[protein] + diphosphate => (2E)-geranyl diphosphate + L-tryptophyl-[protein]"}
{"X":47689,"RHEA_ID":56139,"compounds":"2 a phenolic donor + H2O2 <=> 2 a phenolic radical donor + 2 H2O"}
{"X":47690,"RHEA_ID":49413,"DIRECTION":"LR","MASTER_ID":49412,"metacyc":"RXN-17516","compounds":"beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-colitose => alpha-L-colitosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP + H(+)"}
{"X":47691,"RHEA_ID":46116,"compounds":"2-dehydro-3-deoxy-D-galactonate = D-glyceraldehyde + pyruvate"}
{"X":47692,"RHEA_ID":59498,"compounds":"(20S)-ginsenoside C-K + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":47693,"RHEA_ID":46118,"compounds":"D-glyceraldehyde + pyruvate => 2-dehydro-3-deoxy-D-galactonate"}
{"X":47694,"RHEA_ID":49417,"DIRECTION":"LR","MASTER_ID":49416,"metacyc":"RXN-17377","compounds":"ADP + alpha-D-ribose 1-phosphate => alpha-D-ribose 1,5-bisphosphate + AMP + H(+)"}
{"X":47695,"RHEA_ID":46120,"compounds":"4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 4beta,7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47696,"RHEA_ID":52804,"DIRECTION":"UN","MASTER_ID":52804,"ec":"4.2.3.164","compounds":"(2E,6E)-farnesyl diphosphate = (+)-eremophilene + diphosphate"}
{"X":47697,"RHEA_ID":46122,"compounds":"4beta,7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":47698,"RHEA_ID":49421,"DIRECTION":"LR","MASTER_ID":49420,"metacyc":"RXN-9144","compounds":"ATP + valienone => ADP + H(+) + valienone 7-phosphate"}
{"X":47699,"RHEA_ID":46124,"DIRECTION":"UN","MASTER_ID":46124,"ec":"1.14.14.26","compounds":"(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47700,"RHEA_ID":56150,"compounds":"CoA + hexadecanoyl-sn-glycero-3-phosphocholine => hexadecanoyl-CoA + sn-glycerol 3-phosphocholine"}
{"X":47701,"RHEA_ID":46126,"compounds":"(24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":47702,"RHEA_ID":56152,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphocholine = (9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":47703,"RHEA_ID":46128,"compounds":"cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 4beta-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47704,"RHEA_ID":59510,"compounds":"S-(2-succinyl)-L-cysteinyl-[protein] => fumarate + L-cysteinyl-[protein]"}
{"X":47705,"RHEA_ID":46130,"compounds":"4beta-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":47706,"RHEA_ID":46131,"compounds":"cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 4beta-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47707,"RHEA_ID":46132,"compounds":"cholesterol + H(+) + NADPH + O2 = 25-hydroxycholesterol + H2O + NADP(+)"}
{"X":47708,"RHEA_ID":59514,"compounds":"O-acetyl-L-seryl-[protein] + salicylate => acetylsalicylate + L-seryl-[protein]"}
{"X":47709,"RHEA_ID":46134,"compounds":"25-hydroxycholesterol + H2O + NADP(+) => cholesterol + H(+) + NADPH + O2"}
{"X":47710,"RHEA_ID":46135,"compounds":"cholesterol + H(+) + NADPH + O2 <=> 25-hydroxycholesterol + H2O + NADP(+)"}
{"X":47711,"RHEA_ID":46136,"compounds":"aminopyrrolnitrin + H(+) + NADPH + 2 O2 = 2 H2O + NADP(+) + pyrrolnitrin"}
{"X":47712,"RHEA_ID":56162,"compounds":"an archaeal dolichyl beta-D-glucuronosyl-(1->4)-alpha-D-glucosyl phosphate + H(+) + UDP => an archaeal dolichyl alpha-D-glucosyl phosphate + UDP-alpha-D-glucuronate"}
{"X":47713,"RHEA_ID":46138,"compounds":"2 H2O + NADP(+) + pyrrolnitrin => aminopyrrolnitrin + H(+) + NADPH + 2 O2"}
{"X":47714,"RHEA_ID":46139,"compounds":"aminopyrrolnitrin + H(+) + NADPH + 2 O2 <=> 2 H2O + NADP(+) + pyrrolnitrin"}
{"X":47715,"RHEA_ID":46140,"compounds":"cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 22R-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47716,"RHEA_ID":56166,"compounds":"(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA => (9Z,12Z,15Z)-octadecatrienoyl-CoA + sn-glycerol 3-phosphocholine"}
{"X":47717,"RHEA_ID":56167,"compounds":"(9Z,12Z,15Z)-octadecatrienoyl-CoA + sn-glycerol 3-phosphocholine <=> (9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":47718,"RHEA_ID":46143,"compounds":"cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 22R-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47719,"RHEA_ID":46144,"compounds":"cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47720,"RHEA_ID":56170,"compounds":"(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine"}
{"X":47721,"RHEA_ID":49444,"DIRECTION":"UN","MASTER_ID":49444,"ec":"3.1.2.32","compounds":"(2-aminobenzoyl)acetyl-CoA + H2O = (2-aminobenzoyl)acetate + CoA + H(+)"}
{"X":47722,"RHEA_ID":46147,"compounds":"cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47723,"RHEA_ID":46148,"compounds":"a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside + H(+) + triphosphate"}
{"X":47724,"RHEA_ID":59530,"compounds":"CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein] => hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein]"}
{"X":47725,"RHEA_ID":49448,"DIRECTION":"UN","MASTER_ID":49448,"ec":"3.2.1.197","compounds":"beta-D-Manp-(1->2)-beta-D-Manp-(1->2)-D-Manp + H2O = alpha-D-mannopyranose + beta-D-mannopyranosyl-(1->2)-D-mannopyranose"}
{"X":47726,"RHEA_ID":46151,"compounds":"a 2'-deoxyribonucleoside 5'-triphosphate + H2O <=> a 2'-deoxyribonucleoside + H(+) + triphosphate"}
{"X":47727,"RHEA_ID":46152,"compounds":"15-cis-phytoene + a plastoquinone = 15,9'-di-cis-phytofluene + a plastoquinol"}
{"X":47728,"RHEA_ID":56177,"DIRECTION":"LR","MASTER_ID":56176,"metacyc":"RXN-18508","compounds":"8-demethyl-8-formylriboflavin 5'-phosphate + A + H2O => 8-carboxy-8-demethylriboflavin 5'-phosphate + AH2 + H(+)"}
{"X":47729,"RHEA_ID":56179,"compounds":"8-demethyl-8-formylriboflavin 5'-phosphate + A + H2O <=> 8-carboxy-8-demethylriboflavin 5'-phosphate + AH2 + H(+)"}
{"X":47730,"RHEA_ID":56180,"compounds":"8-carboxy-8-demethylriboflavin 5'-phosphate + 2 A + H2O + L-glutamate = 2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 2 AH2 + CO2"}
{"X":47731,"RHEA_ID":46156,"compounds":"15,9'-di-cis-phytofluene + a plastoquinone = 9,9',15-tri-cis-zeta-carotene + a plastoquinol"}
{"X":47732,"RHEA_ID":56182,"compounds":"2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 2 AH2 + CO2 => 8-carboxy-8-demethylriboflavin 5'-phosphate + 2 A + H2O + L-glutamate"}
{"X":47733,"RHEA_ID":49456,"DIRECTION":"UN","MASTER_ID":49456,"ec":"3.3.2.15","compounds":"(2S)-2-amino-4-deoxychorismate + H2O = (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate + pyruvate"}
{"X":47734,"RHEA_ID":56184,"compounds":"globoside Gb4Cer + UDP-alpha-D-galactose = globoside NOR1 + H(+) + UDP"}
{"X":47735,"RHEA_ID":46160,"DIRECTION":"UN","MASTER_ID":46160,"ec":"1.6.5.2","compounds":"a quinone + H(+) + NADH = a quinol + NAD(+)"}
{"X":47736,"RHEA_ID":56186,"compounds":"globoside NOR1 + H(+) + UDP => globoside Gb4Cer + UDP-alpha-D-galactose"}
{"X":47737,"RHEA_ID":46161,"DIRECTION":"LR","MASTER_ID":46160,"ecocyc":"NQOR-RXN","metacyc":"NQOR-RXN","compounds":"a quinone + H(+) + NADH => a quinol + NAD(+)"}
{"X":47738,"RHEA_ID":46162,"compounds":"a quinol + NAD(+) => a quinone + H(+) + NADH"}
{"X":47739,"RHEA_ID":59546,"compounds":"H2O2 + N,N'-diacetylchitobiono-1,5-lactone => N,N'-diacetylchitobiose + O2"}
{"X":47740,"RHEA_ID":46164,"DIRECTION":"UN","MASTER_ID":46164,"ec":"1.6.5.10","compounds":"a quinone + H(+) + NADPH = a quinol + NADP(+)"}
{"X":47741,"RHEA_ID":46165,"DIRECTION":"LR","MASTER_ID":46164,"ecocyc":"NQOR-RXN","metacyc":"RXN0-271","compounds":"a quinone + H(+) + NADPH => a quinol + NADP(+)"}
{"X":47742,"RHEA_ID":46165,"DIRECTION":"LR","MASTER_ID":46164,"ecocyc":"NQOR-RXN","metacyc":"NQOR-RXN","compounds":"a quinone + H(+) + NADPH => a quinol + NADP(+)"}
{"X":47743,"RHEA_ID":56194,"compounds":"3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":47744,"RHEA_ID":46168,"compounds":"ATP + CoA + pentanoate = AMP + diphosphate + pentanoyl-CoA"}
{"X":47745,"RHEA_ID":46169,"compounds":"ATP + CoA + pentanoate => AMP + diphosphate + pentanoyl-CoA"}
{"X":47746,"RHEA_ID":56198,"compounds":"H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-alpha-D-galactose"}
{"X":47747,"RHEA_ID":46172,"compounds":"ATP + butanoate + CoA = AMP + butanoyl-CoA + diphosphate"}
{"X":47748,"RHEA_ID":46173,"compounds":"ATP + butanoate + CoA => AMP + butanoyl-CoA + diphosphate"}
{"X":47749,"RHEA_ID":56202,"compounds":"H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-alpha-D-galactose"}
{"X":47750,"RHEA_ID":46176,"compounds":"2-methylpropanoate + ATP + CoA = 2-methylpropanoyl-CoA + AMP + diphosphate"}
{"X":47751,"RHEA_ID":46177,"compounds":"2-methylpropanoate + ATP + CoA => 2-methylpropanoyl-CoA + AMP + diphosphate"}
{"X":47752,"RHEA_ID":49478,"compounds":"H(+) + L-2-aminoadipate + NADH => 2 H2O + L-1-piperideine-6-carboxylate + NAD(+)"}
{"X":47753,"RHEA_ID":46179,"compounds":"2-methylpropanoate + ATP + CoA <=> 2-methylpropanoyl-CoA + AMP + diphosphate"}
{"X":47754,"RHEA_ID":46180,"compounds":"2-methylbutanoate + ATP + CoA = 2-methylbutanoyl-CoA + AMP + diphosphate"}
{"X":47755,"RHEA_ID":46181,"compounds":"2-methylbutanoate + ATP + CoA => 2-methylbutanoyl-CoA + AMP + diphosphate"}
{"X":47756,"RHEA_ID":56210,"compounds":"3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP + H(+) => CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein]"}
{"X":47757,"RHEA_ID":46183,"compounds":"2-methylbutanoate + ATP + CoA <=> 2-methylbutanoyl-CoA + AMP + diphosphate"}
{"X":47758,"RHEA_ID":46184,"compounds":"ATP + CoA + isovalerate = 3-methylbutanoyl-CoA + AMP + diphosphate"}
{"X":47759,"RHEA_ID":46185,"compounds":"ATP + CoA + isovalerate => 3-methylbutanoyl-CoA + AMP + diphosphate"}
{"X":47760,"RHEA_ID":49486,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(in) + ATP + H2O"}
{"X":47761,"RHEA_ID":46188,"DIRECTION":"UN","MASTER_ID":46188,"ec":"3.5.5.7","metacyc":"3.5.5.7-RXN","compounds":"an aliphatic nitrile + 2 H2O = a carboxylate + NH4(+)"}
{"X":47762,"RHEA_ID":46189,"compounds":"an aliphatic nitrile + 2 H2O => a carboxylate + NH4(+)"}
{"X":47763,"RHEA_ID":49490,"compounds":"2-oxoglutarate + GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+) => GDP-4-dehydro-alpha-D-rhamnose + L-glutamate"}
{"X":47764,"RHEA_ID":46192,"compounds":"3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] = 3beta,7alpha-dihydroxyandrost-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47765,"RHEA_ID":46193,"compounds":"3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] => 3beta,7alpha-dihydroxyandrost-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47766,"RHEA_ID":56222,"compounds":"3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-seryl-[protein] + H(+) + UDP => 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":47767,"RHEA_ID":46196,"compounds":"O2 + pregnenolone + reduced [NADPH--hemoprotein reductase] = 7alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47768,"RHEA_ID":46197,"compounds":"O2 + pregnenolone + reduced [NADPH--hemoprotein reductase] => 7alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47769,"RHEA_ID":56225,"DIRECTION":"LR","MASTER_ID":56224,"metacyc":"2.4.1.146-RXN","compounds":"3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-threonyl-[protein] + H(+) + UDP"}
{"X":47770,"RHEA_ID":56226,"compounds":"3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-threonyl-[protein] + H(+) + UDP => 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":47771,"RHEA_ID":59582,"compounds":"CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester => hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester"}
{"X":47772,"RHEA_ID":46201,"compounds":"5alpha-androstane-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase] => 5alpha-androstane-3beta,6alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47773,"RHEA_ID":46202,"compounds":"5alpha-androstane-3beta,6alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 5alpha-androstane-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":47774,"RHEA_ID":56229,"compounds":"(9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphocholine => (9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":47775,"RHEA_ID":46204,"compounds":"androst-5-en-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase] = androst-5-en-3beta,7alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47776,"RHEA_ID":46205,"compounds":"androst-5-en-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase] => androst-5-en-3beta,7alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47777,"RHEA_ID":56232,"DIRECTION":"UN","MASTER_ID":56232,"ec":"3.2.1.82","compounds":"[(1->4)-alpha-D-galacturonosyl](n) + H2O = [(1->4)-alpha-D-galacturonosyl](n-2) + alpha-D-galacturonosyl-(1->4)-D-galacturonate"}
{"X":47778,"RHEA_ID":56233,"DIRECTION":"LR","MASTER_ID":56232,"metacyc":"3.2.1.82-RXN","compounds":"[(1->4)-alpha-D-galacturonosyl](n) + H2O => [(1->4)-alpha-D-galacturonosyl](n-2) + alpha-D-galacturonosyl-(1->4)-D-galacturonate"}
{"X":47779,"RHEA_ID":49508,"compounds":"phosphinomethylmalate = 2-(phosphinatomethylidene)butanedioate + H2O"}
{"X":47780,"RHEA_ID":46209,"compounds":"ATP + CoA + eicosanoate => AMP + diphosphate + eicosanoyl-CoA"}
{"X":47781,"RHEA_ID":56236,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine"}
{"X":47782,"RHEA_ID":49511,"compounds":"phosphinomethylmalate <=> 2-(phosphinatomethylidene)butanedioate + H2O"}
{"X":47783,"RHEA_ID":59594,"compounds":"ADP + beta-alanyl-L-arginine + H(+) + phosphate => ATP + beta-alanine + L-arginine"}
{"X":47784,"RHEA_ID":46213,"compounds":"H2O + N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine => 4-amino-5-aminomethyl-2-methylpyrimidine + formate"}
{"X":47785,"RHEA_ID":56240,"compounds":"1,2-dioctanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] = 2-octanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl octanoate + apo--[retinol-binding protein]"}
{"X":47786,"RHEA_ID":49515,"compounds":"2-(phosphinatomethylidene)butanedioate + H2O <=> phosphinomethylisomalate"}
{"X":47787,"RHEA_ID":59610,"compounds":"beta-alanine + L-lysine => beta-alanyl-L-lysine + H2O"}
{"X":47788,"RHEA_ID":46217,"compounds":"H(+) + NADPH + progesterone => 3beta-hydroxypregn-4-ene-20-one + NADP(+)"}
{"X":47789,"RHEA_ID":56244,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] = 2-hexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl hexadecanoate + apo--[retinol-binding protein]"}
{"X":47790,"RHEA_ID":49519,"DIRECTION":"BI","MASTER_ID":49516,"metacyc":"RXN-17810","compounds":"2-oxoglutarate + N(1)-methyladenosine in mRNA + O2 <=> adenosine in mRNA + CO2 + formaldehyde + succinate"}
{"X":47791,"RHEA_ID":49520,"DIRECTION":"UN","MASTER_ID":49520,"ec":"1.14.11.53","compounds":"2-oxoglutarate + N(6)-methyladenosine in mRNA + O2 = adenosine in mRNA + CO2 + formaldehyde + succinate"}
{"X":47792,"RHEA_ID":46221,"compounds":"androst-5-en-3beta,17beta-diol + NAD(+) => 3beta-hydroxyandrost-5-en-17-one + H(+) + NADH"}
{"X":47793,"RHEA_ID":46222,"compounds":"3beta-hydroxyandrost-5-en-17-one + H(+) + NADH => androst-5-en-3beta,17beta-diol + NAD(+)"}
{"X":47794,"RHEA_ID":56249,"compounds":"1,2-didodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] => 2-dodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl dodecanoate + apo--[retinol-binding protein]"}
{"X":47795,"RHEA_ID":59618,"compounds":"beta-alanine + L-arginine => beta-alanyl-L-arginine + H2O"}
{"X":47796,"RHEA_ID":46225,"compounds":"(E)-feruloyl-CoA + H2O => CoA + H(+) + trans-ferulate"}
{"X":47797,"RHEA_ID":46226,"compounds":"CoA + H(+) + trans-ferulate => (E)-feruloyl-CoA + H2O"}
{"X":47798,"RHEA_ID":56253,"DIRECTION":"LR","MASTER_ID":56252,"metacyc":"RXN-18949","compounds":"3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-seryl-[protein] + UDP"}
{"X":47799,"RHEA_ID":49528,"DIRECTION":"UN","MASTER_ID":49528,"ec":"3.1.1.101","compounds":"(ethylene terephthalate)(n) + H2O = (ethylene terephthalate)(n-1) + 4-[(2-hydroxyethoxy)carbonyl]benzoate + H(+)"}
{"X":47800,"RHEA_ID":46229,"compounds":"apo-[peptidyl-carrier protein] + CoA => adenosine 3',5'-bisphosphate + H(+) + holo-[peptidyl-carrier protein]"}
{"X":47801,"RHEA_ID":56256,"compounds":"3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-threonyl-[protein] + UDP"}
{"X":47802,"RHEA_ID":46231,"compounds":"apo-[peptidyl-carrier protein] + CoA <=> adenosine 3',5'-bisphosphate + H(+) + holo-[peptidyl-carrier protein]"}
{"X":47803,"RHEA_ID":59626,"compounds":"4-aminobutanoate + L-ornithine => H2O + N(2)-(4-aminobutanoyl)-L-ornithine"}
{"X":47804,"RHEA_ID":46233,"DIRECTION":"LR","MASTER_ID":46232,"metacyc":"RXN-9617","compounds":"(9Z,12Z)-hexadecadienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => (9Z,12Z,15Z)-hexadecatrienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":47805,"RHEA_ID":56260,"compounds":"N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP-alpha-D-galactose = 4 H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP"}
{"X":47806,"RHEA_ID":46235,"compounds":"(9Z,12Z)-hexadecadienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z,15Z)-hexadecatrienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":47807,"RHEA_ID":49536,"compounds":"2-amino-2-deoxy-D-gluconate = (2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate + H2O"}
{"X":47808,"RHEA_ID":46237,"DIRECTION":"LR","MASTER_ID":46236,"metacyc":"RXN-13858","compounds":"2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a (5Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 H2O"}
{"X":47809,"RHEA_ID":49538,"compounds":"(2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate + H2O => 2-amino-2-deoxy-D-gluconate"}
{"X":47810,"RHEA_ID":46239,"compounds":"2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a (5Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 H2O"}
{"X":47811,"RHEA_ID":46240,"DIRECTION":"UN","MASTER_ID":46240,"ec":"1.14.19.34","compounds":"2 [Fe(II)-cytochrome b5] + a (9Z)-hexadecenoyl-containing glycerolipid + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a (9Z,12E)-hexadecadienoyl-containing glycerolipid + 2 H2O"}
{"X":47812,"RHEA_ID":46241,"DIRECTION":"LR","MASTER_ID":46240,"metacyc":"RXN-16163","compounds":"2 [Fe(II)-cytochrome b5] + a (9Z)-hexadecenoyl-containing glycerolipid + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a (9Z,12E)-hexadecadienoyl-containing glycerolipid + 2 H2O"}
{"X":47813,"RHEA_ID":46242,"compounds":"2 [Fe(III)-cytochrome b5] + a (9Z,12E)-hexadecadienoyl-containing glycerolipid + 2 H2O => 2 [Fe(II)-cytochrome b5] + a (9Z)-hexadecenoyl-containing glycerolipid + 2 H(+) + O2"}
{"X":47814,"RHEA_ID":59637,"compounds":"D-xylotriose + O2 => D-xylotriono-1,5-lactone + H2O2"}
{"X":47815,"RHEA_ID":49544,"compounds":"(4S,5R)-4,5,6-trihydroxy-2-iminohexanoate + H2O = 2-dehydro-3-deoxy-D-gluconate + NH4(+)"}
{"X":47816,"RHEA_ID":46245,"DIRECTION":"LR","MASTER_ID":46244,"metacyc":"RXN-16230","compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 => (14E)-hexadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":47817,"RHEA_ID":46246,"compounds":"(14E)-hexadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => 2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2"}
{"X":47818,"RHEA_ID":56273,"compounds":"4 [Fe(III)cytochrome cL] + H2O + methanol => 4 [Fe(II)cytochrome cL] + formate + 5 H(+)"}
{"X":47819,"RHEA_ID":49548,"DIRECTION":"UN","MASTER_ID":49548,"ec":"3.5.1.124","compounds":"H2O + N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein] = H(+) + L-arginyl-[protein] + lactate"}
{"X":47820,"RHEA_ID":46249,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 => (14Z)-hexadecenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":47821,"RHEA_ID":56276,"compounds":"ATP + L-proline = 3'-L-prolyl-AMP + diphosphate"}
{"X":47822,"RHEA_ID":49552,"DIRECTION":"UN","MASTER_ID":49552,"ec":"3.5.1.124","compounds":"H2O + N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein] = H(+) + L-lysyl-[protein] + lactate"}
{"X":47823,"RHEA_ID":46253,"DIRECTION":"LR","MASTER_ID":46252,"metacyc":"RXN-12797","compounds":"2 [Fe(II)-cytochrome b5] + a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-containing glycerolipid + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-containing glycerolipid + 2 H2O"}
{"X":47824,"RHEA_ID":49554,"compounds":"H(+) + L-lysyl-[protein] + lactate => H2O + N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein]"}
{"X":47825,"RHEA_ID":49556,"DIRECTION":"UN","MASTER_ID":49556,"ec":"3.5.1.124","compounds":"H2O + S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein] = H(+) + L-cysteinyl-[protein] + lactate"}
{"X":47826,"RHEA_ID":46257,"compounds":"2 [Fe(II)-cytochrome b5] + a (7Z,10Z,13Z,16Z)-docosatetraenoyl-containing glycerolipid + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-containing glycerolipid + 2 H2O"}
{"X":47827,"RHEA_ID":56284,"DIRECTION":"UN","MASTER_ID":56284,"ec":"1.1.1.348","compounds":"a (3R,4R)-4,2'-dihydroxyisoflavan + NADP(+) = a (3R)-2'-hydroxyisoflavanone + H(+) + NADPH"}
{"X":47828,"RHEA_ID":49560,"DIRECTION":"UN","MASTER_ID":49560,"ec":"4.2.3.154","compounds":"D-sedoheptulose 7-phosphate = (R)-demethyl-4-deoxygadusol + H(+) + H2O + phosphate"}
{"X":47829,"RHEA_ID":46261,"DIRECTION":"LR","MASTER_ID":46260,"metacyc":"RXN-8346","compounds":"2 [Fe(II)-cytochrome b5] + an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 H(+) + O2 => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-containing glycerolipid + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":47830,"RHEA_ID":46262,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-containing glycerolipid + 2 [Fe(III)-cytochrome b5] + 2 H2O => 2 [Fe(II)-cytochrome b5] + an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 H(+) + O2"}
{"X":47831,"RHEA_ID":49563,"compounds":"D-sedoheptulose 7-phosphate <=> (R)-demethyl-4-deoxygadusol + H(+) + H2O + phosphate"}
{"X":47832,"RHEA_ID":49564,"DIRECTION":"UN","MASTER_ID":49564,"ec":"4.2.3.155","compounds":"D-sedoheptulose 7-phosphate = 2-epi-valiolone + phosphate"}
{"X":47833,"RHEA_ID":46265,"DIRECTION":"LR","MASTER_ID":46264,"metacyc":"RXN-8350","compounds":"2 [Fe(II)-cytochrome b5] + an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-containing glycerolipid + 2 H2O"}
{"X":47834,"RHEA_ID":56292,"DIRECTION":"UN","MASTER_ID":56292,"ec":"1.14.14.75","compounds":"fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] = 4'-hydroxyfenbendazole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47835,"RHEA_ID":59661,"compounds":"D-cellotetraose + O2 => D-cellotetraono-1,5-lactone + H2O2"}
{"X":47836,"RHEA_ID":49568,"DIRECTION":"UN","MASTER_ID":49568,"ec":"4.4.1.34","compounds":"2-glutathionyl-2-methylbut-3-en-1-ol = (3R)-3,4-epoxy-3-methylbut-1-ene + glutathione"}
{"X":47837,"RHEA_ID":46269,"DIRECTION":"LR","MASTER_ID":46268,"metacyc":"RXN-7798","compounds":"2 [Fe(II)-cytochrome b5] + an N-acyl-(4R)-4-hydroxysphinganine + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a (4R,8E)-4-hydroxysphingenine ceramide + 2 H2O"}
{"X":47838,"RHEA_ID":46270,"compounds":"2 [Fe(III)-cytochrome b5] + a (4R,8E)-4-hydroxysphingenine ceramide + 2 H2O => 2 [Fe(II)-cytochrome b5] + an N-acyl-(4R)-4-hydroxysphinganine + 2 H(+) + O2"}
{"X":47839,"RHEA_ID":56297,"DIRECTION":"LR","MASTER_ID":56296,"ecocyc":"RXN-18702","metacyc":"RXN-18702","compounds":"3-mercaptopyruvate + L-cysteinyl-[protein] => pyruvate + S-sulfanyl-L-cysteinyl-[protein]"}
{"X":47840,"RHEA_ID":49572,"DIRECTION":"UN","MASTER_ID":49572,"ec":"4.99.1.9","compounds":"Fe-coproporphyrin III + 2 H(+) = coproporphyrin III + Fe(2+)"}
{"X":47841,"RHEA_ID":46273,"compounds":"2 [Fe(II)-cytochrome b5] + an N-acyl-(4R)-4-hydroxysphinganine + 2 H(+) + O2 => (4R,8Z)-4-hydroxysphing-8-enine ceramide + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":47842,"RHEA_ID":56300,"compounds":"[thioredoxin]-dithiol + S-sulfanyl-L-cysteinyl-[protein] = [thioredoxin]-disulfide + H(+) + hydrogen sulfide + L-cysteinyl-[protein]"}
{"X":47843,"RHEA_ID":59669,"compounds":"D-cellohexaose + O2 => D-cellohexaono-1,5-lactone + H2O2"}
{"X":47844,"RHEA_ID":49576,"DIRECTION":"UN","MASTER_ID":49576,"ec":"4.1.99.22","compounds":"AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine"}
{"X":47845,"RHEA_ID":46277,"DIRECTION":"LR","MASTER_ID":46276,"metacyc":"RXN-16819","compounds":"(S)-malate + H(+) => (S)-lactate + CO2"}
{"X":47846,"RHEA_ID":46278,"compounds":"(S)-lactate + CO2 => (S)-malate + H(+)"}
{"X":47847,"RHEA_ID":59673,"compounds":"D-maltotriose + O2 => D-maltotriono-1,5-lactone + H2O2"}
{"X":47848,"RHEA_ID":56306,"compounds":"21-phosphorifampicin + AMP + 2 H(+) + phosphate => ATP + H2O + rifampicin"}
{"X":47849,"RHEA_ID":46281,"DIRECTION":"LR","MASTER_ID":46280,"metacyc":"RXN-16374","compounds":"2 [Fe(II)-cytochrome b5] + an N-acylsphing-4-enine + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 H2O"}
{"X":47850,"RHEA_ID":46282,"compounds":"2 [Fe(III)-cytochrome b5] + a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 H2O => 2 [Fe(II)-cytochrome b5] + an N-acylsphing-4-enine + 2 H(+) + O2"}
{"X":47851,"RHEA_ID":49584,"DIRECTION":"UN","MASTER_ID":49584,"ec":"5.1.3.38","compounds":"D-erythrulose 1-phosphate = L-erythrulose 1-phosphate"}
{"X":47852,"RHEA_ID":46285,"DIRECTION":"LR","MASTER_ID":46284,"metacyc":"RXN-11680","compounds":"2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 => (6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":47853,"RHEA_ID":56312,"DIRECTION":"UN","MASTER_ID":56312,"ec":"3.6.1.52","metacyc":"RXN-10976","compounds":"3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + 2 H(+) + phosphate"}
{"X":47854,"RHEA_ID":59681,"compounds":"D-maltopentaose + O2 => D-maltopentaono-1,5-lactone + H2O2"}
{"X":47855,"RHEA_ID":49588,"DIRECTION":"UN","MASTER_ID":49588,"ec":"5.3.1.33","compounds":"L-erythrulose 1-phosphate = D-erythrulose 4-phosphate"}
{"X":47856,"RHEA_ID":46289,"DIRECTION":"LR","MASTER_ID":46288,"metacyc":"RXN-8347","compounds":"(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => (6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":47857,"RHEA_ID":46290,"compounds":"(6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 [Fe(III)-cytochrome b5] + 2 H2O => (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}
{"X":47858,"RHEA_ID":46291,"compounds":"(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> (6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":47859,"RHEA_ID":49592,"DIRECTION":"UN","MASTER_ID":49592,"ec":"5.4.99.64","compounds":"2-hydroxyisobutanoyl-CoA = (3S)-hydroxybutanoyl-CoA"}
{"X":47860,"RHEA_ID":46293,"compounds":"a 5'-end triphospho-(purine-ribonucleotide) in mRNA + GDP + H(+) => a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + diphosphate"}
{"X":47861,"RHEA_ID":49594,"compounds":"(3S)-hydroxybutanoyl-CoA => 2-hydroxyisobutanoyl-CoA"}
{"X":47862,"RHEA_ID":49596,"compounds":"an N-acylsphing-4-enine + UDP-alpha-D-galactose = H(+) + N-acyl-D-galactosylsphing-4-enine + UDP"}
{"X":47863,"RHEA_ID":46297,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 6beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47864,"RHEA_ID":49598,"compounds":"H(+) + N-acyl-D-galactosylsphing-4-enine + UDP => an N-acylsphing-4-enine + UDP-alpha-D-galactose"}
{"X":47865,"RHEA_ID":46299,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 6beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47866,"RHEA_ID":52990,"compounds":"[deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + propane-1,3-diamine => [deoxyhypusine synthase]-L-lysine + dehydrospermidine"}
{"X":47867,"RHEA_ID":46301,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 2-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47868,"RHEA_ID":46302,"compounds":"2-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone"}
{"X":47869,"RHEA_ID":46303,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 2-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47870,"RHEA_ID":49604,"compounds":"2-glutathionyl-2-methylbut-3-en-1-ol + NAD(+) = 2-glutathionyl-2-methylbut-3-enal + H(+) + NADH"}
{"X":47871,"RHEA_ID":56331,"compounds":"5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + H2O <=> 5'-triphosphoadenylyl-(2'->5')-adenosine + AMP + H(+)"}
{"X":47872,"RHEA_ID":46306,"compounds":"16beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone"}
{"X":47873,"RHEA_ID":46307,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 16beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47874,"RHEA_ID":56334,"compounds":"AMP + ATP + H(+) => 5'-triphosphoadenylyl-(2'->5')-adenosine + H2O"}
{"X":47875,"RHEA_ID":56335,"compounds":"5'-triphosphoadenylyl-(2'->5')-adenosine + H2O <=> AMP + ATP + H(+)"}
{"X":47876,"RHEA_ID":46310,"compounds":"17alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + progesterone + reduced [NADPH--hemoprotein reductase]"}
{"X":47877,"RHEA_ID":46311,"compounds":"O2 + progesterone + reduced [NADPH--hemoprotein reductase] <=> 17alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47878,"RHEA_ID":56338,"compounds":"ent-isokaurene-2beta,3beta-diol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => ent-isokaurene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}
{"X":47879,"RHEA_ID":56339,"compounds":"ent-isokaurene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> ent-isokaurene-2beta,3beta-diol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":47880,"RHEA_ID":46314,"DIRECTION":"RL","MASTER_ID":46312,"metacyc":"RXN-12710","compounds":"3,22-dioxochol-4-en-24-oyl-CoA + CoA => 3-oxochol-4-en-22-oyl-CoA + acetyl-CoA"}
{"X":47881,"RHEA_ID":46315,"compounds":"3-oxochol-4-en-22-oyl-CoA + acetyl-CoA <=> 3,22-dioxochol-4-en-24-oyl-CoA + CoA"}
{"X":47882,"RHEA_ID":49616,"DIRECTION":"UN","MASTER_ID":49616,"ec":"1.2.1.98","compounds":"2-hydroxy-2-methylpropanal + H2O + NAD(+) = 2-hydroxy-2-methylpropanoate + 2 H(+) + NADH"}
{"X":47883,"RHEA_ID":56343,"compounds":"ent-isokauren-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-isokaurene-2beta,3beta-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47884,"RHEA_ID":59712,"compounds":"D-maltotetraono-1,5-lactone + H2O = D-maltotetraonate + H(+)"}
{"X":47885,"RHEA_ID":56345,"DIRECTION":"LR","MASTER_ID":56344,"metacyc":"ISOFLAVONE-7-O-GLUCOSYLTRANSFERASE-RXN","compounds":"a 7-hydroxyisoflavone + UDP-alpha-D-glucose => a 7-hydroxyisoflavone 7-O-beta-D-glucoside + H(+) + UDP"}
{"X":47886,"RHEA_ID":56346,"compounds":"a 7-hydroxyisoflavone 7-O-beta-D-glucoside + H(+) + UDP => a 7-hydroxyisoflavone + UDP-alpha-D-glucose"}
{"X":47887,"RHEA_ID":46321,"compounds":"3beta-hydroxy-chol-5-ene-24-oyl-CoA + A => 3beta-hydroxy-chol-5,22-dien-24-oyl-CoA + AH2"}
{"X":47888,"RHEA_ID":56348,"DIRECTION":"UN","MASTER_ID":56348,"ec":"1.14.19.55","compounds":"4-hydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 = 2,4-dibromophenol + CO2 + 4 H2O + 2 NADP(+)"}
{"X":47889,"RHEA_ID":46323,"compounds":"3beta-hydroxy-chol-5-ene-24-oyl-CoA + A <=> 3beta-hydroxy-chol-5,22-dien-24-oyl-CoA + AH2"}
{"X":47890,"RHEA_ID":49624,"DIRECTION":"UN","MASTER_ID":49624,"ec":"2.7.1.215","compounds":"ATP + erythritol = ADP + D-erythritol 1-phosphate + H(+)"}
{"X":47891,"RHEA_ID":46325,"DIRECTION":"LR","MASTER_ID":46324,"metacyc":"RXN-12743","compounds":"3-oxochol-4-en-22-oyl-CoA + A => 3-oxochola-4,17-dien-22-oyl-CoA + AH2"}
{"X":47892,"RHEA_ID":56352,"compounds":"4-hydroxybenzoate + bromide + 2 H(+) + NADPH + O2 = 3-bromo-4-hydroxybenzoate + 2 H2O + NADP(+)"}
{"X":47893,"RHEA_ID":46327,"compounds":"3-oxochol-4-en-22-oyl-CoA + A <=> 3-oxochola-4,17-dien-22-oyl-CoA + AH2"}
{"X":47894,"RHEA_ID":46328,"compounds":"L-threo-3-phenylserine = 3-phenylpyruvate + NH4(+)"}
{"X":47895,"RHEA_ID":46329,"compounds":"L-threo-3-phenylserine => 3-phenylpyruvate + NH4(+)"}
{"X":47896,"RHEA_ID":49630,"compounds":"3,5-dimethylorsellinate + 3 CO2 + 4 CoA + 2 S-adenosyl-L-homocysteine => acetyl-CoA + 3 malonyl-CoA + 2 S-adenosyl-L-methionine"}
{"X":47897,"RHEA_ID":46331,"compounds":"L-threo-3-phenylserine <=> 3-phenylpyruvate + NH4(+)"}
{"X":47898,"RHEA_ID":56358,"compounds":"2,4-dibromophenol + CO2 + 2 H2O + NADP(+) => 3-bromo-4-hydroxybenzoate + bromide + 3 H(+) + NADPH + O2"}
{"X":47899,"RHEA_ID":49633,"compounds":"(2E,6E)-farnesyl diphosphate + 3,5-dimethylorsellinate => (3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + diphosphate + H(+)"}
{"X":47900,"RHEA_ID":59728,"compounds":"(2R)-ethylmalonyl-CoA = (2S)-ethylmalonyl-CoA"}
{"X":47901,"RHEA_ID":46335,"compounds":"2 [Fe(II)-cytochrome b5] + a (9Z)-octadecenoyl-containing glycerolipid + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H2O"}
{"X":47902,"RHEA_ID":56362,"compounds":"13-dihydrocarminomycin + H2O + NADP(+) => 13-deoxycarminomycin + H(+) + NADPH + O2"}
{"X":47903,"RHEA_ID":46337,"compounds":"3-oxochola-4,17-dien-22-oyl-CoA + H2O => 17-hydroxy-3-oxochol-4-en-22-oyl-CoA"}
{"X":47904,"RHEA_ID":59732,"compounds":"biotinyl-5'-AMP + L-lysyl-[protein] = AMP + 2 H(+) + N(6)-biotinyl-L-lysyl-[protein]"}
{"X":47905,"RHEA_ID":46339,"compounds":"3-oxochola-4,17-dien-22-oyl-CoA + H2O <=> 17-hydroxy-3-oxochol-4-en-22-oyl-CoA"}
{"X":47906,"RHEA_ID":56366,"compounds":"carminomycin + 2 H2O + NADP(+) => 13-dihydrocarminomycin + H(+) + NADPH + O2"}
{"X":47907,"RHEA_ID":46341,"compounds":"ATP + N-hexadecanoylsphing-4-enine => ADP + H(+) + N-(hexadecanoyl)-sphing-4-enine-1-phosphate"}
{"X":47908,"RHEA_ID":46342,"compounds":"ADP + H(+) + N-(hexadecanoyl)-sphing-4-enine-1-phosphate => ATP + N-hexadecanoylsphing-4-enine"}
{"X":47909,"RHEA_ID":46343,"compounds":"ATP + N-hexadecanoylsphing-4-enine <=> ADP + H(+) + N-(hexadecanoyl)-sphing-4-enine-1-phosphate"}
{"X":47910,"RHEA_ID":56370,"compounds":"3,5-dibromobenzene-1,2-diol + CO2 + 4 H2O + 2 NADP(+) => 3,4-dihydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2"}
{"X":47911,"RHEA_ID":46345,"compounds":"propanoyl-CoA + tetradecanoyl-CoA => 3-oxo-2-methylhexadecanoyl-CoA + CoA"}
{"X":47912,"RHEA_ID":56372,"compounds":"3,4-dihydroxybenzoate + bromide + 2 H(+) + NADPH + O2 = 3-bromo-4,5-dihydroxybenzoate + 2 H2O + NADP(+)"}
{"X":47913,"RHEA_ID":46347,"compounds":"propanoyl-CoA + tetradecanoyl-CoA <=> 3-oxo-2-methylhexadecanoyl-CoA + CoA"}
{"X":47914,"RHEA_ID":56374,"compounds":"3-bromo-4,5-dihydroxybenzoate + 2 H2O + NADP(+) => 3,4-dihydroxybenzoate + bromide + 2 H(+) + NADPH + O2"}
{"X":47915,"RHEA_ID":46349,"compounds":"(2E)-octenoyl-CoA + H2O => 3-hydroxyoctanoyl-CoA"}
{"X":47916,"RHEA_ID":46350,"compounds":"3-hydroxyoctanoyl-CoA => (2E)-octenoyl-CoA + H2O"}
{"X":47917,"RHEA_ID":56377,"DIRECTION":"LR","MASTER_ID":56376,"metacyc":"RXN-19113","compounds":"3-bromo-4,5-dihydroxybenzoate + bromide + 3 H(+) + NADPH + O2 => 3,5-dibromobenzene-1,2-diol + CO2 + 2 H2O + NADP(+)"}
{"X":47918,"RHEA_ID":56378,"compounds":"3,5-dibromobenzene-1,2-diol + CO2 + 2 H2O + NADP(+) => 3-bromo-4,5-dihydroxybenzoate + bromide + 3 H(+) + NADPH + O2"}
{"X":47919,"RHEA_ID":46353,"compounds":"(2E)-decenoyl-CoA + H2O => 3-hydroxydecanoyl-CoA"}
{"X":47920,"RHEA_ID":46354,"compounds":"3-hydroxydecanoyl-CoA => (2E)-decenoyl-CoA + H2O"}
{"X":47921,"RHEA_ID":46355,"compounds":"(2E)-decenoyl-CoA + H2O <=> 3-hydroxydecanoyl-CoA"}
{"X":47922,"RHEA_ID":49708,"DIRECTION":"UN","MASTER_ID":49708,"ec":"2.5.1.38","compounds":"nocardicin G + S-adenosyl-L-methionine = H(+) + isonocardicin C + S-methyl-5'-thioadenosine"}
{"X":47923,"RHEA_ID":46357,"DIRECTION":"LR","MASTER_ID":46356,"metacyc":"RXN-16399","compounds":"O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] => 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47924,"RHEA_ID":46358,"compounds":"18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + octadecanoate + reduced [NADPH--hemoprotein reductase]"}
{"X":47925,"RHEA_ID":56385,"DIRECTION":"LR","MASTER_ID":56384,"metacyc":"RXN-19081","compounds":"(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2 => (5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O"}
{"X":47926,"RHEA_ID":46360,"DIRECTION":"UN","MASTER_ID":46360,"ec":"1.14.18.4","compounds":"1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 1-acyl-2-[(R)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":47927,"RHEA_ID":46361,"DIRECTION":"LR","MASTER_ID":46360,"metacyc":"PHOSPHATIDYLCHOLINE-12-MONOOXYGENASE-RXN","compounds":"1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 1-acyl-2-[(R)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":47928,"RHEA_ID":49718,"compounds":"3,5-dihydroxy-4-methylanthranilyl-[aryl-carrier protein] + H2O + NAD(+) => 3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] + H(+) + NADH + O2"}
{"X":47929,"RHEA_ID":56389,"DIRECTION":"LR","MASTER_ID":56388,"metacyc":"RXN-19082","compounds":"(5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2 => (4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O"}
{"X":47930,"RHEA_ID":46364,"DIRECTION":"UN","MASTER_ID":46364,"ec":"1.14.18.5","compounds":"2 [Fe(II)-cytochrome b5] + an N-acylsphinganine + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + an N-acyl-(4R)-4-hydroxysphinganine + H2O"}
{"X":47931,"RHEA_ID":46365,"DIRECTION":"LR","MASTER_ID":46364,"metacyc":"RXN-14250","compounds":"2 [Fe(II)-cytochrome b5] + an N-acylsphinganine + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + an N-acyl-(4R)-4-hydroxysphinganine + H2O"}
{"X":47932,"RHEA_ID":49722,"compounds":"CO2 + 2 H2O + NAD(+) + violacein => 2 H(+) + NADH + 2 O2 + protoviolaceinate"}
{"X":47933,"RHEA_ID":56393,"compounds":"[(3R)-hydroxybutanoate](n) + H2O => (3R)-hydroxybutanoate dimer + [(3R)-hydroxybutanoate](n-2) + H(+)"}
{"X":47934,"RHEA_ID":46368,"DIRECTION":"UN","MASTER_ID":46368,"ec":"1.14.19.33","compounds":"2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a (9Z,11E,13E)-octadecatrienoyl-containing glycerolipid + 2 H2O"}
{"X":47935,"RHEA_ID":46369,"DIRECTION":"LR","MASTER_ID":46368,"metacyc":"RXN-8413","compounds":"2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a (9Z,11E,13E)-octadecatrienoyl-containing glycerolipid + 2 H2O"}
{"X":47936,"RHEA_ID":49730,"compounds":"CO2 + 2 H2O + NADP(+) + violacein => 2 H(+) + NADPH + 2 O2 + protoviolaceinate"}
{"X":47937,"RHEA_ID":56397,"compounds":"[(3R)-hydroxybutanoate](n) + H2O => (3R)-hydroxybutanoate trimer + [(3R)-hydroxybutanoate](n-3) + H(+)"}
{"X":47938,"RHEA_ID":46372,"DIRECTION":"UN","MASTER_ID":46372,"ec":"1.14.19.33","compounds":"(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a (9Z,11E,13E,15Z)-octadecatetraenoyl-containing glycerolipid + 2 H2O"}
{"X":47939,"RHEA_ID":46373,"DIRECTION":"LR","MASTER_ID":46372,"metacyc":"RXN-16159","compounds":"(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a (9Z,11E,13E,15Z)-octadecatetraenoyl-containing glycerolipid + 2 H2O"}
{"X":47940,"RHEA_ID":56400,"DIRECTION":"UN","MASTER_ID":56400,"ec":"3.1.1.75","compounds":"[(3R)-hydroxybutanoate](n) + H2O = (3R)-hydroxybutanoate tetramer + [(3R)-hydroxybutanoate](n-4) + H(+)"}
{"X":47941,"RHEA_ID":46375,"compounds":"(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a (9Z,11E,13E,15Z)-octadecatetraenoyl-containing glycerolipid + 2 H2O"}
{"X":47942,"RHEA_ID":46376,"DIRECTION":"UN","MASTER_ID":46376,"ec":"1.14.19.23","compounds":"a (9Z)-octadecenoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":47943,"RHEA_ID":46377,"DIRECTION":"LR","MASTER_ID":46376,"metacyc":"RXN-16036","compounds":"a (9Z)-octadecenoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":47944,"RHEA_ID":49738,"compounds":"CO2 + deoxyviolacein + 2 H2O + NAD(+) => 2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate"}
{"X":47945,"RHEA_ID":56405,"compounds":"[(3R)-hydroxybutanoate](n) + H2O => (3R)-hydroxybutanoate pentamer + [(3R)-hydroxybutanoate](n-5) + H(+)"}
{"X":47946,"RHEA_ID":46380,"compounds":"7alpha-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47947,"RHEA_ID":46381,"compounds":"7alpha-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47948,"RHEA_ID":56408,"compounds":"(9Z,12Z,15Z)-octadecatrienoyl-CoA + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1-(9Z-octadecaenoyl)-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":47949,"RHEA_ID":56409,"compounds":"(9Z,12Z,15Z)-octadecatrienoyl-CoA + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-(9Z-octadecaenoyl)-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":47950,"RHEA_ID":46384,"compounds":"(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 24S,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47951,"RHEA_ID":46385,"compounds":"(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 24S,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47952,"RHEA_ID":49746,"compounds":"CO2 + deoxyviolacein + H2O => deoxyviolaceinate + H(+) + O2"}
{"X":47953,"RHEA_ID":56413,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-ditetradecanoyl-sn-glycerol"}
{"X":47954,"RHEA_ID":46388,"compounds":"(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S,25R)-24,26-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47955,"RHEA_ID":46389,"compounds":"(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24S,25R)-24,26-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47956,"RHEA_ID":56416,"DIRECTION":"UN","MASTER_ID":56416,"ec":"2.4.1.359","compounds":"2-O-(alpha-D-glucopyranosyl)glycerol + phosphate = alpha-D-glucose 1-phosphate + glycerol"}
{"X":47957,"RHEA_ID":56417,"compounds":"2-O-(alpha-D-glucopyranosyl)glycerol + phosphate => alpha-D-glucose 1-phosphate + glycerol"}
{"X":47958,"RHEA_ID":46392,"compounds":"4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 4beta,24S-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47959,"RHEA_ID":46393,"compounds":"4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 4beta,24S-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47960,"RHEA_ID":46394,"compounds":"4beta,24S-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":47961,"RHEA_ID":46395,"compounds":"4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 4beta,24S-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":47962,"RHEA_ID":46396,"DIRECTION":"UN","MASTER_ID":46396,"ec":"1.14.19.24","compounds":"2 [Fe(II)-cytochrome b5] + an 11,12-saturated fatty acyl-CoA + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + an (11E)-Delta(11)-fatty acyl-CoA + 2 H2O"}
{"X":47963,"RHEA_ID":46397,"compounds":"2 [Fe(II)-cytochrome b5] + an 11,12-saturated fatty acyl-CoA + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + an (11E)-Delta(11)-fatty acyl-CoA + 2 H2O"}
{"X":47964,"RHEA_ID":46398,"compounds":"2 [Fe(III)-cytochrome b5] + an (11E)-Delta(11)-fatty acyl-CoA + 2 H2O => 2 [Fe(II)-cytochrome b5] + an 11,12-saturated fatty acyl-CoA + 2 H(+) + O2"}
{"X":47965,"RHEA_ID":56425,"compounds":"H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => (9Z,12Z)-octadecadienoate + H(+) + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":47966,"RHEA_ID":46400,"compounds":"cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-cholest-5-ene-3beta,26-diol + H2O + 2 oxidized [adrenodoxin]"}
{"X":47967,"RHEA_ID":46401,"compounds":"cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-cholest-5-ene-3beta,26-diol + H2O + 2 oxidized [adrenodoxin]"}
{"X":47968,"RHEA_ID":46402,"compounds":"(25R)-cholest-5-ene-3beta,26-diol + H2O + 2 oxidized [adrenodoxin] => cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}
{"X":47969,"RHEA_ID":56429,"compounds":"1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O => (9Z,12Z)-octadecadienoate + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":47970,"RHEA_ID":46404,"DIRECTION":"UN","MASTER_ID":46404,"ec":"1.14.19.25","compounds":"2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 = (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":47971,"RHEA_ID":46405,"DIRECTION":"LR","MASTER_ID":46404,"metacyc":"RXN-16046","compounds":"2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 => (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":47972,"RHEA_ID":46406,"compounds":"(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(III)-cytochrome b5] + 2 H2O => 2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2"}
{"X":47973,"RHEA_ID":56433,"compounds":"1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate"}
{"X":47974,"RHEA_ID":46408,"DIRECTION":"UN","MASTER_ID":46408,"ec":"1.14.19.35","compounds":"a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":47975,"RHEA_ID":46409,"DIRECTION":"LR","MASTER_ID":46408,"metacyc":"RXN-9667","compounds":"a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":47976,"RHEA_ID":46410,"compounds":"(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":47977,"RHEA_ID":46411,"compounds":"a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":47978,"RHEA_ID":56438,"compounds":"2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":47979,"RHEA_ID":46413,"DIRECTION":"LR","MASTER_ID":46412,"metacyc":"RXN-16049","compounds":"a (7Z,10Z)-hexadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a (7Z,10Z,13Z)-hexadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":47980,"RHEA_ID":46414,"compounds":"a (7Z,10Z,13Z)-hexadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a (7Z,10Z)-hexadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":47981,"RHEA_ID":56441,"compounds":"1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":47982,"RHEA_ID":46416,"DIRECTION":"UN","MASTER_ID":46416,"ec":"1.14.19.26","compounds":"2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (6Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":47983,"RHEA_ID":46417,"DIRECTION":"LR","MASTER_ID":46416,"metacyc":"RXN-8388","compounds":"2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (6Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":47984,"RHEA_ID":46418,"compounds":"(6Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":47985,"RHEA_ID":56445,"compounds":"1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate"}
{"X":47986,"RHEA_ID":46420,"DIRECTION":"UN","MASTER_ID":46420,"ec":"1.14.19.44","compounds":"(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":47987,"RHEA_ID":46421,"DIRECTION":"LR","MASTER_ID":46420,"metacyc":"RXN-13429","compounds":"(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":47988,"RHEA_ID":46422,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O => (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}
{"X":47989,"RHEA_ID":56449,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)"}
{"X":47990,"RHEA_ID":59842,"compounds":"(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-O-methylgallate => (6S)-5,6,7,8-tetrahydrofolate + syringate"}
{"X":47991,"RHEA_ID":46425,"DIRECTION":"LR","MASTER_ID":46424,"metacyc":"RXN-16064","compounds":"(8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":47992,"RHEA_ID":56452,"DIRECTION":"UN","MASTER_ID":56452,"ec":"5.5.1.32","compounds":"3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole = 12-epi-hapalindole U"}
{"X":47993,"RHEA_ID":56453,"DIRECTION":"LR","MASTER_ID":56452,"metacyc":"RXN-19273","compounds":"3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole => 12-epi-hapalindole U"}
{"X":47994,"RHEA_ID":46428,"compounds":"4beta-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-4beta,26-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin]"}
{"X":47995,"RHEA_ID":46429,"compounds":"4beta-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-4beta,26-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin]"}
{"X":47996,"RHEA_ID":56456,"DIRECTION":"UN","MASTER_ID":56456,"ec":"5.5.1.33","compounds":"3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole = 12-epi-fischerindole U"}
{"X":47997,"RHEA_ID":56457,"DIRECTION":"LR","MASTER_ID":56456,"metacyc":"RXN-19282","compounds":"3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole => 12-epi-fischerindole U"}
{"X":47998,"RHEA_ID":46432,"compounds":"(25R)-4beta,26-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta,4beta-dihydroxycholest-5-en-26-al + 2 H2O + 2 oxidized [adrenodoxin]"}
{"X":47999,"RHEA_ID":46433,"compounds":"(25R)-4beta,26-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta,4beta-dihydroxycholest-5-en-26-al + 2 H2O + 2 oxidized [adrenodoxin]"}
{"X":48000,"RHEA_ID":56460,"compounds":"H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine"}
{"X":48001,"RHEA_ID":56461,"compounds":"H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine"}
{"X":48002,"RHEA_ID":59854,"compounds":"(R)-tetrahydrodehydrodiconiferyl alcohol + NADP(+) => (2S,3R)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH"}
{"X":48003,"RHEA_ID":46437,"compounds":"(25R)-3beta,4beta-dihydroxycholest-5-en-26-al + H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta,4beta-dihydroxycholest-5-en-26-oate + H2O + 2 oxidized [adrenodoxin]"}
{"X":48004,"RHEA_ID":46438,"compounds":"(25R)-3beta,4beta-dihydroxycholest-5-en-26-oate + H2O + 2 oxidized [adrenodoxin] => (25R)-3beta,4beta-dihydroxycholest-5-en-26-al + H(+) + O2 + 2 reduced [adrenodoxin]"}
{"X":48005,"RHEA_ID":46439,"compounds":"(25R)-3beta,4beta-dihydroxycholest-5-en-26-al + H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta,4beta-dihydroxycholest-5-en-26-oate + H2O + 2 oxidized [adrenodoxin]"}
{"X":48006,"RHEA_ID":46440,"DIRECTION":"UN","MASTER_ID":46440,"ec":"1.14.19.14","compounds":"a (9Z,12Z)-octadecadienoyl-containing glycerolipid + AH2 + O2 = A + a (8E,10E,12Z)-octadecatrienoyl-containing glycerolipid + 2 H2O"}
{"X":48007,"RHEA_ID":46441,"DIRECTION":"LR","MASTER_ID":46440,"metacyc":"RXN-8411","compounds":"a (9Z,12Z)-octadecadienoyl-containing glycerolipid + AH2 + O2 => A + a (8E,10E,12Z)-octadecatrienoyl-containing glycerolipid + 2 H2O"}
{"X":48008,"RHEA_ID":56468,"DIRECTION":"UN","MASTER_ID":56468,"ec":"1.14.19.57","compounds":"(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 bromide + 3 FADH2 + 3 O2 = (3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 FAD + 6 H2O"}
{"X":48009,"RHEA_ID":56469,"DIRECTION":"LR","MASTER_ID":56468,"metacyc":"RXN-19072","compounds":"(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 bromide + 3 FADH2 + 3 O2 => (3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 FAD + 6 H2O"}
{"X":48010,"RHEA_ID":46444,"DIRECTION":"UN","MASTER_ID":46444,"ec":"1.14.19.15","compounds":"(11Z)-hexadecenoyl-CoA + AH2 + O2 = (10E,12Z)-hexadecadienoyl-CoA + A + 2 H2O"}
{"X":48011,"RHEA_ID":46445,"DIRECTION":"LR","MASTER_ID":46444,"metacyc":"RXN-15113","compounds":"(11Z)-hexadecenoyl-CoA + AH2 + O2 => (10E,12Z)-hexadecadienoyl-CoA + A + 2 H2O"}
{"X":48012,"RHEA_ID":56472,"compounds":"(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 = (5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O"}
{"X":48013,"RHEA_ID":56474,"compounds":"(5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O => (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2"}
{"X":48014,"RHEA_ID":46449,"DIRECTION":"LR","MASTER_ID":46448,"metacyc":"RXN-14336","compounds":"2 L-tyrosyl-tRNA(Tyr) => cyclo(L-tyrosyl-L-tyrosyl) + 2 tRNA(Tyr)"}
{"X":48015,"RHEA_ID":46450,"compounds":"cyclo(L-tyrosyl-L-tyrosyl) + 2 tRNA(Tyr) => 2 L-tyrosyl-tRNA(Tyr)"}
{"X":48016,"RHEA_ID":56477,"DIRECTION":"LR","MASTER_ID":56476,"metacyc":"RXN-19095","compounds":"(5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 => (4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O"}
{"X":48017,"RHEA_ID":46452,"DIRECTION":"UN","MASTER_ID":46452,"ec":"2.3.2.22","compounds":"2 L-leucyl-tRNA(Leu) = cyclo(L-leucyl-L-leucyl) + 2 H(+) + 2 tRNA(Leu)"}
{"X":48018,"RHEA_ID":46453,"DIRECTION":"LR","MASTER_ID":46452,"metacyc":"RXN8J2-80","compounds":"2 L-leucyl-tRNA(Leu) => cyclo(L-leucyl-L-leucyl) + 2 H(+) + 2 tRNA(Leu)"}
{"X":48019,"RHEA_ID":46454,"compounds":"cyclo(L-leucyl-L-leucyl) + 2 H(+) + 2 tRNA(Leu) => 2 L-leucyl-tRNA(Leu)"}
{"X":48020,"RHEA_ID":56481,"DIRECTION":"LR","MASTER_ID":56480,"metacyc":"RXN-19096","compounds":"(4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 => (3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O"}
{"X":48021,"RHEA_ID":46456,"compounds":"5alpha-cholest-8,14-dien-3beta-ol + H(+) + NADPH = 5alpha-cholest-8-en-3beta-ol + NADP(+)"}
{"X":48022,"RHEA_ID":49841,"DIRECTION":"LR","MASTER_ID":49840,"metacyc":"RXN-17552","compounds":"(-)-dehydrodiconiferyl acid + 2 a quinone + H2O => (-)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+)"}
{"X":48023,"RHEA_ID":46458,"compounds":"5alpha-cholest-8-en-3beta-ol + NADP(+) => 5alpha-cholest-8,14-dien-3beta-ol + H(+) + NADPH"}
{"X":48024,"RHEA_ID":56485,"DIRECTION":"LR","MASTER_ID":56484,"metacyc":"RXN-19691","compounds":"3 O2 + oleanolate + 3 reduced [NADPH--hemoprotein reductase] => gypsogenate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}
{"X":48025,"RHEA_ID":46460,"compounds":"22R-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (22R,7alpha)-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":48026,"RHEA_ID":56487,"compounds":"3 O2 + oleanolate + 3 reduced [NADPH--hemoprotein reductase] <=> gypsogenate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}
{"X":48027,"RHEA_ID":46462,"compounds":"(22R,7alpha)-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 22R-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":48028,"RHEA_ID":56489,"compounds":"O2 + oleanolate + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + hederagenin + oxidized [NADPH--hemoprotein reductase]"}
{"X":48029,"RHEA_ID":46464,"compounds":"(24S)-25-epoxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S,25)-epoxy-7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":48030,"RHEA_ID":56491,"compounds":"O2 + oleanolate + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + hederagenin + oxidized [NADPH--hemoprotein reductase]"}
{"X":48031,"RHEA_ID":46466,"compounds":"(24S,25)-epoxy-7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (24S)-25-epoxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":48032,"RHEA_ID":56493,"compounds":"hederagenin + O2 + reduced [NADPH--hemoprotein reductase] => gypsogenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":48033,"RHEA_ID":46468,"compounds":"an N-(acyl)-sphingosylphosphocholine(in) + ATP + H2O = ADP + an N-(acyl)-sphingosylphosphocholine(out) + H(+) + phosphate"}
{"X":48034,"RHEA_ID":46469,"compounds":"an N-(acyl)-sphingosylphosphocholine(in) + ATP + H2O => ADP + an N-(acyl)-sphingosylphosphocholine(out) + H(+) + phosphate"}
{"X":48035,"RHEA_ID":46470,"compounds":"ADP + an N-(acyl)-sphingosylphosphocholine(out) + H(+) + phosphate => an N-(acyl)-sphingosylphosphocholine(in) + ATP + H2O"}
{"X":48036,"RHEA_ID":56497,"compounds":"gypsogenin + O2 + reduced [NADPH--hemoprotein reductase] => gypsogenate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":48037,"RHEA_ID":46472,"compounds":"4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":48038,"RHEA_ID":46473,"compounds":"4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":48039,"RHEA_ID":56500,"DIRECTION":"UN","MASTER_ID":56500,"ec":"4.1.1.110","compounds":"(R)-3,5-bisphosphomevalonate + H(+) = CO2 + isopentenyl phosphate + phosphate"}
{"X":48040,"RHEA_ID":46475,"compounds":"4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":48041,"RHEA_ID":46476,"compounds":"4alpha-hydroxymethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 4alpha-formyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":48042,"RHEA_ID":46477,"compounds":"4alpha-hydroxymethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 4alpha-formyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":48043,"RHEA_ID":56504,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":48044,"RHEA_ID":56505,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":48045,"RHEA_ID":56506,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}
{"X":48046,"RHEA_ID":46481,"compounds":"4alpha-formyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 => 4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":48047,"RHEA_ID":56508,"DIRECTION":"UN","MASTER_ID":56508,"ec":"2.4.1.135","compounds":"3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H(+) + UDP"}
{"X":48048,"RHEA_ID":46483,"compounds":"4alpha-formyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":48049,"RHEA_ID":56510,"compounds":"3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate"}
{"X":48050,"RHEA_ID":46485,"DIRECTION":"LR","MASTER_ID":46484,"metacyc":"RXN-11326","compounds":"alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate => alpha-Kdo-(2->4)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)"}
{"X":48051,"RHEA_ID":46486,"compounds":"alpha-Kdo-(2->4)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+) => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate"}
{"X":48052,"RHEA_ID":46487,"compounds":"alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate <=> alpha-Kdo-(2->4)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)"}
{"X":48053,"RHEA_ID":56514,"compounds":"3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + phosphate => 3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H2O"}
{"X":48054,"RHEA_ID":46489,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out)"}
{"X":48055,"RHEA_ID":56516,"DIRECTION":"UN","MASTER_ID":56516,"ec":"1.3.98.5","compounds":"Fe-coproporphyrin III + 2 H(+) + 2 H2O2 = 2 CO2 + 4 H2O + heme b"}
{"X":48056,"RHEA_ID":46491,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out)"}
{"X":48057,"RHEA_ID":46492,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(in) = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(out)"}
{"X":48058,"RHEA_ID":46493,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(in) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(out)"}
{"X":48059,"RHEA_ID":49878,"compounds":"(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":48060,"RHEA_ID":56521,"DIRECTION":"LR","MASTER_ID":56520,"metacyc":"RXN-15808","compounds":"Fe-coproporphyrin III + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + 2 CO2 + heme b + 2 L-methionine"}
{"X":48061,"RHEA_ID":46496,"compounds":"N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(in) = N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(out)"}
{"X":48062,"RHEA_ID":46497,"compounds":"N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(in) => N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(out)"}
{"X":48063,"RHEA_ID":46498,"compounds":"N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(out) => N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(in)"}
{"X":48064,"RHEA_ID":56525,"DIRECTION":"LR","MASTER_ID":56524,"metacyc":"RXN-15807","compounds":"A + dihydro-heme d1 => AH2 + heme d1"}
{"X":48065,"RHEA_ID":56526,"compounds":"AH2 + heme d1 => A + dihydro-heme d1"}
{"X":48066,"RHEA_ID":46501,"DIRECTION":"LR","MASTER_ID":46500,"metacyc":"RXN-14397","compounds":"2-oxoglutarate + O2 + UMP => CO2 + phosphate + succinate + uridine-5'-aldehyde"}
{"X":48067,"RHEA_ID":46502,"compounds":"CO2 + phosphate + succinate + uridine-5'-aldehyde => 2-oxoglutarate + O2 + UMP"}
{"X":48068,"RHEA_ID":56529,"DIRECTION":"LR","MASTER_ID":56528,"metacyc":"RXN-19634","compounds":"chloride + D-tryptophan + FADH2 + O2 => 6-chloro-D-tryptophan + FAD + 2 H2O"}
{"X":48069,"RHEA_ID":56530,"compounds":"6-chloro-D-tryptophan + FAD + 2 H2O => chloride + D-tryptophan + FADH2 + O2"}
{"X":48070,"RHEA_ID":46505,"compounds":"dodecanoyl-AMP + holo-[ACP] => AMP + dodecanoyl-[ACP] + H(+)"}
{"X":48071,"RHEA_ID":46506,"compounds":"AMP + dodecanoyl-[ACP] + H(+) => dodecanoyl-AMP + holo-[ACP]"}
{"X":48072,"RHEA_ID":56533,"compounds":"H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine phosphate => N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + phosphate"}
{"X":48073,"RHEA_ID":46508,"DIRECTION":"UN","MASTER_ID":46508,"ec":"1.14.12.23","compounds":"NADH + nitrobenzene + O2 = catechol + NAD(+) + nitrite"}
{"X":48074,"RHEA_ID":46509,"DIRECTION":"LR","MASTER_ID":46508,"metacyc":"RXN-3661","compounds":"NADH + nitrobenzene + O2 => catechol + NAD(+) + nitrite"}
{"X":48075,"RHEA_ID":56536,"compounds":"(12R)-hydroxy-(9Z)-octadecenoyl-CoA + 1,2-di-(12R-hydroxy-9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(12R-hydroxy-9Z-octadecenoyl)-glycerol + CoA"}
{"X":48076,"RHEA_ID":59937,"compounds":"3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA + H(+)"}
{"X":48077,"RHEA_ID":56538,"compounds":"1,2,3-tri-(12R-hydroxy-9Z-octadecenoyl)-glycerol + CoA => (12R)-hydroxy-(9Z)-octadecenoyl-CoA + 1,2-di-(12R-hydroxy-9Z-octadecenoyl)-sn-glycerol"}
{"X":48078,"RHEA_ID":46513,"DIRECTION":"LR","MASTER_ID":46512,"metacyc":"RXN-7796","compounds":"2 [Fe(II)-cytochrome b5] + an N-(1,2-saturated acyl)sphinganine + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + an N-[(2'R)-hydroxyacyl]sphinganine + H2O"}
{"X":48079,"RHEA_ID":46514,"compounds":"2 [Fe(III)-cytochrome b5] + an N-[(2'R)-hydroxyacyl]sphinganine + H2O => 2 [Fe(II)-cytochrome b5] + an N-(1,2-saturated acyl)sphinganine + 2 H(+) + O2"}
{"X":48080,"RHEA_ID":56541,"compounds":"(9Z)-octadecenoyl-CoA + 1,2-dihexanoyl-sn-glycerol => 1,2-dihexanoyl-3-(9Z-octadecenoyl)-sn-glycerol + CoA"}
{"X":48081,"RHEA_ID":46520,"DIRECTION":"UN","MASTER_ID":46520,"ec":"1.14.18.6","compounds":"2 [Fe(II)-cytochrome b5] + an N-(1,2 saturated acyl)-4R-hydroxysphinganine + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + an N-(2R-hydroxyacyl)-4R-hydroxysphinganine + H2O"}
{"X":48082,"RHEA_ID":46521,"DIRECTION":"LR","MASTER_ID":46520,"metacyc":"RXN3O-4042","compounds":"2 [Fe(II)-cytochrome b5] + an N-(1,2 saturated acyl)-4R-hydroxysphinganine + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + an N-(2R-hydroxyacyl)-4R-hydroxysphinganine + H2O"}
{"X":48083,"RHEA_ID":56544,"compounds":"H2O + N-hexadecanoyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}
{"X":48084,"RHEA_ID":56545,"compounds":"H2O + N-hexadecanoyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}
{"X":48085,"RHEA_ID":46524,"DIRECTION":"UN","MASTER_ID":46524,"ec":"1.14.19.37","compounds":"(11Z,14Z)-eicosadienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (5Z,11Z,14Z)-eicosatrienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":48086,"RHEA_ID":46525,"DIRECTION":"LR","MASTER_ID":46524,"metacyc":"RXN-11677","compounds":"(11Z,14Z)-eicosadienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => (5Z,11Z,14Z)-eicosatrienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":48087,"RHEA_ID":49906,"compounds":"(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + CO2 + H2O2 => (1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + H(+) + O2"}
{"X":48088,"RHEA_ID":56549,"compounds":"H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine"}
{"X":48089,"RHEA_ID":56550,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-diacyl-sn-glycero-3-phosphoethanolamine"}
{"X":48090,"RHEA_ID":46529,"DIRECTION":"LR","MASTER_ID":46528,"metacyc":"RXN-11678","compounds":"(11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":48091,"RHEA_ID":56552,"DIRECTION":"UN","MASTER_ID":56552,"ec":"2.7.11.14","compounds":"[rhodopsin]-L-threonine + ATP = [rhodopsin]-O-phospho-L-threonine + ADP + H(+)"}
{"X":48092,"RHEA_ID":56553,"compounds":"[rhodopsin]-L-threonine + ATP => [rhodopsin]-O-phospho-L-threonine + ADP + H(+)"}
{"X":48093,"RHEA_ID":56554,"compounds":"[rhodopsin]-O-phospho-L-threonine + ADP + H(+) => [rhodopsin]-L-threonine + ATP"}
{"X":48094,"RHEA_ID":46533,"DIRECTION":"LR","MASTER_ID":46532,"metacyc":"RXN-8412","compounds":"2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a (9Z,11E,13Z)-octadeca-9,11,13-trienoyl-containing glycerolipid + 2 H2O"}
{"X":48095,"RHEA_ID":56556,"compounds":"(2E,6E)-farnesyl diphosphate = delta-cadinene + diphosphate"}
{"X":48096,"RHEA_ID":56557,"compounds":"(2E,6E)-farnesyl diphosphate => delta-cadinene + diphosphate"}
{"X":48097,"RHEA_ID":56558,"compounds":"delta-cadinene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":48098,"RHEA_ID":46537,"DIRECTION":"LR","MASTER_ID":46536,"metacyc":"RXN-11681","compounds":"(6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a (9Z,12Z)-octadeca-9,12-dien-6-ynoyl-containing glycerolipid + 2 H2O"}
{"X":48099,"RHEA_ID":46538,"compounds":"2 [Fe(III)-cytochrome b5] + a (9Z,12Z)-octadeca-9,12-dien-6-ynoyl-containing glycerolipid + 2 H2O => (6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}
{"X":48100,"RHEA_ID":56561,"DIRECTION":"LR","MASTER_ID":56560,"metacyc":"RXN-7667","compounds":"[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose => [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + H(+) + UDP"}
{"X":48101,"RHEA_ID":46540,"DIRECTION":"UN","MASTER_ID":46540,"ec":"1.14.19.38","compounds":"(6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a (9Z,12Z,15Z)-octadeca-9,12,15-trien-6-ynoyl-containing glycerolipid + 2 H2O"}
{"X":48102,"RHEA_ID":46541,"DIRECTION":"LR","MASTER_ID":46540,"metacyc":"RXN-11682","compounds":"(6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a (9Z,12Z,15Z)-octadeca-9,12,15-trien-6-ynoyl-containing glycerolipid + 2 H2O"}
{"X":48103,"RHEA_ID":46542,"compounds":"2 [Fe(III)-cytochrome b5] + a (9Z,12Z,15Z)-octadeca-9,12,15-trien-6-ynoyl-containing glycerolipid + 2 H2O => (6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}
{"X":48104,"RHEA_ID":49923,"compounds":"(R)-carnitine(out) + O-octanoyl-(R)-carnitine(in) <=> (R)-carnitine(in) + O-octanoyl-(R)-carnitine(out)"}
{"X":48105,"RHEA_ID":46544,"DIRECTION":"UN","MASTER_ID":46544,"ec":"1.14.19.17","compounds":"2 [Fe(II)-cytochrome b5] + an N-acylsphinganine + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + an N-acylsphing-4-enine + 2 H2O"}
{"X":48106,"RHEA_ID":46545,"DIRECTION":"LR","MASTER_ID":46544,"metacyc":"RXN-16332","compounds":"2 [Fe(II)-cytochrome b5] + an N-acylsphinganine + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + an N-acylsphing-4-enine + 2 H2O"}
{"X":48107,"RHEA_ID":46546,"compounds":"2 [Fe(III)-cytochrome b5] + an N-acylsphing-4-enine + 2 H2O => 2 [Fe(II)-cytochrome b5] + an N-acylsphinganine + 2 H(+) + O2"}
{"X":48108,"RHEA_ID":56568,"compounds":"globoside Gb4Cer + UDP-N-acetyl-alpha-D-galactosamine = globoside IV3GalNAc-Gb4Cer + H(+) + UDP"}
{"X":48109,"RHEA_ID":56569,"compounds":"globoside Gb4Cer + UDP-N-acetyl-alpha-D-galactosamine => globoside IV3GalNAc-Gb4Cer + H(+) + UDP"}
{"X":48110,"RHEA_ID":46549,"DIRECTION":"LR","MASTER_ID":46548,"metacyc":"RXN-16338","compounds":"2 [Fe(II)-cytochrome b5] + a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + 2 H2O + N-acyl-(4E,8E,10E)-sphingatrienine"}
{"X":48111,"RHEA_ID":46550,"compounds":"2 [Fe(III)-cytochrome b5] + 2 H2O + N-acyl-(4E,8E,10E)-sphingatrienine => 2 [Fe(II)-cytochrome b5] + a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 H(+) + O2"}
{"X":48112,"RHEA_ID":49931,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":48113,"RHEA_ID":46552,"DIRECTION":"UN","MASTER_ID":46552,"ec":"1.14.19.39","compounds":"2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a (9Z)-octadec-9-en-12-ynoyl-containing glycerolipid + 2 H2O"}
{"X":48114,"RHEA_ID":46553,"DIRECTION":"LR","MASTER_ID":46552,"metacyc":"1.14.99.33-RXN","compounds":"2 [Fe(II)-cytochrome b5] + a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a (9Z)-octadec-9-en-12-ynoyl-containing glycerolipid + 2 H2O"}
{"X":48115,"RHEA_ID":49934,"compounds":"(2E,5Z)-octadienoyl-CoA => (3E,5Z)-octadienoyl-CoA"}
{"X":48116,"RHEA_ID":56576,"compounds":"globoside Gb3Cer + UDP-N-acetyl-alpha-D-galactosamine = globoside Gb4Cer + H(+) + UDP"}
{"X":48117,"RHEA_ID":56577,"compounds":"globoside Gb3Cer + UDP-N-acetyl-alpha-D-galactosamine => globoside Gb4Cer + H(+) + UDP"}
{"X":48118,"RHEA_ID":46557,"compounds":"5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + cholesta-5,7-dien-3beta-ol + 2 H2O"}
{"X":48119,"RHEA_ID":53244,"compounds":"cholesta-5,7-dien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = cholesta-5,7-dien-3beta,24S-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":48120,"RHEA_ID":49939,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":48121,"RHEA_ID":56581,"compounds":"6-thioguanine + S-adenosyl-L-methionine => 6-methylthioguanine + H(+) + S-adenosyl-L-homocysteine"}
{"X":48122,"RHEA_ID":46561,"DIRECTION":"LR","MASTER_ID":46560,"metacyc":"RXN3O-218","compounds":"2 [Fe(II)-cytochrome b5] + episterol + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + ergosta-5,7,24(28)-trien-3beta-ol + 2 H2O"}
{"X":48123,"RHEA_ID":49942,"compounds":"(10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2 => (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + O2"}
{"X":48124,"RHEA_ID":56583,"compounds":"6-thioguanine + S-adenosyl-L-methionine <=> 6-methylthioguanine + H(+) + S-adenosyl-L-homocysteine"}
{"X":48125,"RHEA_ID":56585,"DIRECTION":"LR","MASTER_ID":56584,"metacyc":"RXN-17617","compounds":"1,2-epoxypropane + H2O => propane-1,2-diol"}
{"X":48126,"RHEA_ID":46565,"compounds":"acetyl-CoA + apo-[ACP] => acetyl-[ACP] + adenosine 3',5'-bisphosphate + H(+)"}
{"X":48127,"RHEA_ID":46566,"compounds":"acetyl-[ACP] + adenosine 3',5'-bisphosphate + H(+) => acetyl-CoA + apo-[ACP]"}
{"X":48128,"RHEA_ID":56588,"DIRECTION":"UN","MASTER_ID":56588,"ec":"4.1.2.47","compounds":"a monosubstituted aliphatic (S)-hydroxynitrile = an aldehyde + hydrogen cyanide"}
{"X":48129,"RHEA_ID":56589,"compounds":"a monosubstituted aliphatic (S)-hydroxynitrile => an aldehyde + hydrogen cyanide"}
{"X":48130,"RHEA_ID":46569,"DIRECTION":"LR","MASTER_ID":46568,"metacyc":"RXN-16464","compounds":"5-hexenoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 5-hexynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":48131,"RHEA_ID":46570,"compounds":"5-hexynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 5-hexenoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":48132,"RHEA_ID":56592,"DIRECTION":"UN","MASTER_ID":56592,"ec":"4.1.2.47","compounds":"a disubstituted aliphatic (S)-hydroxynitrile = a ketone + hydrogen cyanide"}
{"X":48133,"RHEA_ID":46572,"DIRECTION":"UN","MASTER_ID":46572,"ec":"1.14.19.40","compounds":"2 H(+) + hexanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 5-hexenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":48134,"RHEA_ID":46573,"DIRECTION":"LR","MASTER_ID":46572,"metacyc":"RXN-16467","compounds":"2 H(+) + hexanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 5-hexenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":48135,"RHEA_ID":46574,"compounds":"5-hexenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + hexanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":48136,"RHEA_ID":56596,"DIRECTION":"UN","MASTER_ID":56596,"ec":"1.14.14.155","compounds":"(1S,4S)-bornane-2,5-dione + FMNH2 + O2 = (1S,4S)-5-oxo-1,2-campholide + FMN + H(+) + H2O"}
{"X":48137,"RHEA_ID":56597,"compounds":"(1S,4S)-bornane-2,5-dione + FMNH2 + O2 => (1S,4S)-5-oxo-1,2-campholide + FMN + H(+) + H2O"}
{"X":48138,"RHEA_ID":46577,"DIRECTION":"LR","MASTER_ID":46576,"metacyc":"RXN-4243","compounds":"(24R)-ethylcholest-5-en-3beta-ol + H(+) + NADPH + O2 => 2 H2O + NADP(+) + stigmasterol"}
{"X":48139,"RHEA_ID":49958,"compounds":"H2O2 + phenazine-1-carboxylate => 5,10-dihydrophenazine 1-carboxylate + O2"}
{"X":48140,"RHEA_ID":60009,"compounds":"a tRNA precursor + 2 CTP => a tRNA with a 3' CC end + 2 diphosphate"}
{"X":48141,"RHEA_ID":56601,"compounds":"3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-threonyl-[EGF-like domain protein] + UDP-alpha-D-xylose => 3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-threonyl-[EGF-like domain protein] + H(+) + UDP"}
{"X":48142,"RHEA_ID":46581,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + vitamin D2 => 25-hydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":48143,"RHEA_ID":46582,"compounds":"25-hydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + vitamin D2"}
{"X":48144,"RHEA_ID":56604,"compounds":"3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = 6-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)"}
{"X":48145,"RHEA_ID":56605,"compounds":"3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) => 6-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)"}
{"X":48146,"RHEA_ID":46585,"compounds":"1alpha-hydroxyvitamin D2 + O2 + reduced [NADPH--hemoprotein reductase] => 1alpha,25-dihydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":48147,"RHEA_ID":46586,"compounds":"1alpha,25-dihydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 1alpha-hydroxyvitamin D2 + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":48148,"RHEA_ID":60017,"compounds":"(2E,6E)-farnesyl diphosphate => diphosphate + sesquisabinene B"}
{"X":48149,"RHEA_ID":56609,"compounds":"5,10-methylenetetrahydrosulfopterin + glycine + H2O => L-serine + tetrahydrosulfopterin"}
{"X":48150,"RHEA_ID":46589,"compounds":"calciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => calcidiol + H2O + 2 oxidized [adrenodoxin]"}
{"X":48151,"RHEA_ID":46590,"compounds":"calcidiol + H2O + 2 oxidized [adrenodoxin] => calciol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}
{"X":48152,"RHEA_ID":56612,"compounds":"L-cysteinyl-[protein] + NAD(+) = H(+) + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]"}
{"X":48153,"RHEA_ID":46592,"compounds":"alfacalcidol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = calcitriol + H2O + 2 oxidized [adrenodoxin]"}
{"X":48154,"RHEA_ID":46593,"compounds":"alfacalcidol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => calcitriol + H2O + 2 oxidized [adrenodoxin]"}
{"X":48155,"RHEA_ID":46594,"compounds":"calcitriol + H2O + 2 oxidized [adrenodoxin] => alfacalcidol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}
{"X":48156,"RHEA_ID":49975,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":48157,"RHEA_ID":46596,"DIRECTION":"UN","MASTER_ID":46596,"ec":"1.14.13.211","compounds":"NADPH + O2 + rifampicin = 2'-N-hydroxyrifampicin + H2O + NADP(+)"}
{"X":48158,"RHEA_ID":46597,"compounds":"NADPH + O2 + rifampicin => 2'-N-hydroxyrifampicin + H2O + NADP(+)"}
{"X":48159,"RHEA_ID":46598,"compounds":"2'-N-hydroxyrifampicin + H2O + NADP(+) => NADPH + O2 + rifampicin"}
{"X":48160,"RHEA_ID":56620,"compounds":"(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + H2O = 2,4,5-trichlorocyclohexa-2,5-dien-1-ol + chloride + H(+)"}
{"X":48161,"RHEA_ID":46600,"compounds":"[HPr protein]-L-serine + ATP = [HPr protein]-O-phospho-L-serine + ADP + H(+)"}
{"X":48162,"RHEA_ID":46601,"compounds":"[HPr protein]-L-serine + ATP => [HPr protein]-O-phospho-L-serine + ADP + H(+)"}
{"X":48163,"RHEA_ID":46602,"compounds":"[HPr protein]-O-phospho-L-serine + ADP + H(+) => [HPr protein]-L-serine + ATP"}
{"X":48164,"RHEA_ID":56624,"compounds":"2,4,5-trichlorocyclohexa-2,5-dien-1-ol + H2O = 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + chloride + H(+)"}
{"X":48165,"RHEA_ID":60034,"compounds":"8-oxo-GDP + H(+) + phosphate => 8-oxo-GTP + H2O"}
{"X":48166,"RHEA_ID":46605,"compounds":"[HPr protein]-O-phospho-L-serine + H(+) + phosphate => [HPr protein]-L-serine + diphosphate"}
{"X":48167,"RHEA_ID":46606,"compounds":"[HPr protein]-L-serine + diphosphate => [HPr protein]-O-phospho-L-serine + H(+) + phosphate"}
{"X":48168,"RHEA_ID":46607,"compounds":"[HPr protein]-O-phospho-L-serine + H(+) + phosphate <=> [HPr protein]-L-serine + diphosphate"}
{"X":48169,"RHEA_ID":46608,"DIRECTION":"UN","MASTER_ID":46608,"ec":"2.7.11.24","compounds":"ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]"}
{"X":48170,"RHEA_ID":46608,"DIRECTION":"UN","MASTER_ID":46608,"ec":"2.7.11.13","compounds":"ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]"}
{"X":48171,"RHEA_ID":46608,"DIRECTION":"UN","MASTER_ID":46608,"ec":"2.7.12.2","compounds":"ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]"}
{"X":48172,"RHEA_ID":46608,"DIRECTION":"UN","MASTER_ID":46608,"ec":"2.7.11.1","compounds":"ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]"}
{"X":48173,"RHEA_ID":60042,"compounds":"(2E)-3-methylhex-2-enoate + L-glutamine => H2O + N(2)-[(2E)-3-methylhex-2-enoyl]-L-glutaminate"}
{"X":48174,"RHEA_ID":46608,"DIRECTION":"UN","MASTER_ID":46608,"ec":"2.7.11.25","compounds":"ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]"}
{"X":48175,"RHEA_ID":46608,"DIRECTION":"UN","MASTER_ID":46608,"ec":"2.7.12.1","compounds":"ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]"}
{"X":48176,"RHEA_ID":46608,"DIRECTION":"UN","MASTER_ID":46608,"ec":"2.7.11.17","compounds":"ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]"}
{"X":48177,"RHEA_ID":56637,"compounds":"1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O => 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate"}
{"X":48178,"RHEA_ID":46608,"DIRECTION":"UN","MASTER_ID":46608,"ec":"2.7.11.11","compounds":"ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]"}
{"X":48179,"RHEA_ID":46608,"DIRECTION":"UN","MASTER_ID":46608,"ec":"2.7.11.21","compounds":"ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]"}
{"X":48180,"RHEA_ID":46609,"DIRECTION":"LR","MASTER_ID":46608,"ecocyc":"PROTEIN-KINASE-RXN","metacyc":"PROTEIN-KINASE-RXN","compounds":"ATP + L-threonyl-[protein] => ADP + H(+) + O-phospho-L-threonyl-[protein]"}
{"X":48181,"RHEA_ID":56641,"compounds":"1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O => (9Z,12Z)-octadecadienoate + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+)"}
{"X":48182,"RHEA_ID":56642,"compounds":"(9Z,12Z)-octadecadienoate + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O"}
{"X":48183,"RHEA_ID":46612,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z,17Z-eicosapentaenoate) + CoA"}
{"X":48184,"RHEA_ID":46613,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + cholesterol => cholesteryl (5Z,8Z,11Z,14Z,17Z-eicosapentaenoate) + CoA"}
{"X":48185,"RHEA_ID":60054,"compounds":"a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H2O + NAD(+) => a 3beta-hydroxy-4,4-dimethylsteroid + H(+) + NADH + O2"}
{"X":48186,"RHEA_ID":46615,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + cholesterol <=> cholesteryl (5Z,8Z,11Z,14Z,17Z-eicosapentaenoate) + CoA"}
{"X":48187,"RHEA_ID":46616,"compounds":"calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (23S)-23,25-dihydroxycalciol + H2O + 2 oxidized [adrenodoxin]"}
{"X":48188,"RHEA_ID":60057,"DIRECTION":"LR","MASTER_ID":60056,"metacyc":"RXN-20107","compounds":"a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H(+) + NADH + O2 => a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + 2 H2O + NAD(+)"}
{"X":48189,"RHEA_ID":56648,"DIRECTION":"UN","MASTER_ID":56648,"ec":"1.3.1.114","compounds":"3-oxochol-4-en-24-oyl-CoA + NAD(+) = 3-oxochol-4,6-dien-24-oyl-CoA + H(+) + NADH"}
{"X":48190,"RHEA_ID":46619,"compounds":"calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (23S)-23,25-dihydroxycalciol + H2O + 2 oxidized [adrenodoxin]"}
{"X":48191,"RHEA_ID":46620,"compounds":"(9Z,12Z,15Z)-octadecatrienoyl-CoA + cholesterol = cholesteryl (9Z,12Z,15Z)-octadecatrienoate + CoA"}
{"X":48192,"RHEA_ID":46621,"compounds":"(9Z,12Z,15Z)-octadecatrienoyl-CoA + cholesterol => cholesteryl (9Z,12Z,15Z)-octadecatrienoate + CoA"}
{"X":48193,"RHEA_ID":56652,"DIRECTION":"UN","MASTER_ID":56652,"ec":"1.3.1.114","compounds":"12alpha-hydroxy-3-oxocholan-24-oyl-CoA + NAD(+) = 12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH"}
{"X":48194,"RHEA_ID":46623,"compounds":"(9Z,12Z,15Z)-octadecatrienoyl-CoA + cholesterol <=> cholesteryl (9Z,12Z,15Z)-octadecatrienoate + CoA"}
{"X":48195,"RHEA_ID":46624,"DIRECTION":"UN","MASTER_ID":46624,"ec":"5.1.99.5","compounds":"a D-5-monosubstituted hydantoin = a L-5-monosubstituted hydantoin"}
{"X":48196,"RHEA_ID":46625,"compounds":"a D-5-monosubstituted hydantoin => a L-5-monosubstituted hydantoin"}
{"X":48197,"RHEA_ID":60065,"DIRECTION":"LR","MASTER_ID":60064,"metacyc":"RXN-20108","compounds":"a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + NADH + O2 => a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + H2O + NAD(+)"}
{"X":48198,"RHEA_ID":56658,"DIRECTION":"RL","MASTER_ID":56656,"metacyc":"RXN-17402","compounds":"12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H(+) + NADH => 12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NAD(+)"}
{"X":48199,"RHEA_ID":46628,"compounds":"3beta-hydroxyandrost-5-en-17-one + H(+) + NADPH = androst-5-en-3beta,17beta-diol + NADP(+)"}
{"X":48200,"RHEA_ID":46629,"compounds":"3beta-hydroxyandrost-5-en-17-one + H(+) + NADPH => androst-5-en-3beta,17beta-diol + NADP(+)"}
{"X":48201,"RHEA_ID":46630,"compounds":"androst-5-en-3beta,17beta-diol + NADP(+) => 3beta-hydroxyandrost-5-en-17-one + H(+) + NADPH"}
{"X":48202,"RHEA_ID":56662,"compounds":"7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH => 7alpha-hydroxy-3-oxochol-24-oyl-CoA + NAD(+)"}
{"X":48203,"RHEA_ID":46632,"compounds":"7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + NADPH = 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NADP(+)"}
{"X":48204,"RHEA_ID":46633,"compounds":"7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + NADPH => 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NADP(+)"}
{"X":48205,"RHEA_ID":60073,"DIRECTION":"LR","MASTER_ID":60072,"metacyc":"RXN-20112","compounds":"4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADH + O2 => 4beta-hydroxymethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + H2O + NAD(+)"}
{"X":48206,"RHEA_ID":46635,"compounds":"7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + NADPH <=> 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NADP(+)"}
{"X":48207,"RHEA_ID":46636,"DIRECTION":"UN","MASTER_ID":46636,"ec":"1.3.1.3","compounds":"5beta-dihydrotestosterone + NADP(+) = H(+) + NADPH + testosterone"}
{"X":48208,"RHEA_ID":46637,"compounds":"5beta-dihydrotestosterone + NADP(+) => H(+) + NADPH + testosterone"}
{"X":48209,"RHEA_ID":60077,"DIRECTION":"LR","MASTER_ID":60076,"metacyc":"RXN-20113","compounds":"4beta-hydroxymethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADH + O2 => 4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H2O + NAD(+)"}
{"X":48210,"RHEA_ID":60078,"compounds":"4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H2O + NAD(+) => 4beta-hydroxymethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADH + O2"}
{"X":48211,"RHEA_ID":46640,"compounds":"7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH = 7alpha-hydroxy-5beta-cholestan-3-one + NADP(+)"}
{"X":48212,"RHEA_ID":46641,"compounds":"7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH => 7alpha-hydroxy-5beta-cholestan-3-one + NADP(+)"}
{"X":48213,"RHEA_ID":46642,"compounds":"7alpha-hydroxy-5beta-cholestan-3-one + NADP(+) => 7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH"}
{"X":48214,"RHEA_ID":46643,"compounds":"7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH <=> 7alpha-hydroxy-5beta-cholestan-3-one + NADP(+)"}
{"X":48215,"RHEA_ID":46644,"compounds":"cortisol + H(+) + NADPH = 5beta-dihydrocortisol + NADP(+)"}
{"X":48216,"RHEA_ID":46645,"compounds":"cortisol + H(+) + NADPH => 5beta-dihydrocortisol + NADP(+)"}
{"X":48217,"RHEA_ID":56677,"compounds":"dihydroferuloyl-CoA + NADP(+) => (E)-feruloyl-CoA + H(+) + NADPH"}
{"X":48218,"RHEA_ID":56678,"DIRECTION":"RL","MASTER_ID":56676,"metacyc":"RXN-19599","compounds":"(E)-feruloyl-CoA + H(+) + NADPH => dihydroferuloyl-CoA + NADP(+)"}
{"X":48219,"RHEA_ID":46648,"compounds":"17-hydroxy-3-oxochol-4-en-22-oyl-CoA = androst-4-ene-3,17-dione + propanoyl-CoA"}
{"X":48220,"RHEA_ID":46649,"compounds":"17-hydroxy-3-oxochol-4-en-22-oyl-CoA => androst-4-ene-3,17-dione + propanoyl-CoA"}
{"X":48221,"RHEA_ID":46650,"compounds":"androst-4-ene-3,17-dione + propanoyl-CoA => 17-hydroxy-3-oxochol-4-en-22-oyl-CoA"}
{"X":48222,"RHEA_ID":46651,"compounds":"17-hydroxy-3-oxochol-4-en-22-oyl-CoA <=> androst-4-ene-3,17-dione + propanoyl-CoA"}
{"X":48223,"RHEA_ID":46652,"compounds":"epitestosterone + H(+) + NADPH = 5beta-dihydroepitestosterone + NADP(+)"}
{"X":48224,"RHEA_ID":46653,"compounds":"epitestosterone + H(+) + NADPH => 5beta-dihydroepitestosterone + NADP(+)"}
{"X":48225,"RHEA_ID":50044,"compounds":"an acyl-CoA + H2O = acyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)"}
{"X":48226,"RHEA_ID":56686,"compounds":"2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + rhizobitoxine => dihydrorhizobitoxine + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":48227,"RHEA_ID":46656,"compounds":"androst-4-ene-3,17-dione + H(+) + NADPH = 5beta-androstane-3,17-dione + NADP(+)"}
{"X":48228,"RHEA_ID":46657,"compounds":"androst-4-ene-3,17-dione + H(+) + NADPH => 5beta-androstane-3,17-dione + NADP(+)"}
{"X":48229,"RHEA_ID":50048,"compounds":"ATP + cholate(in) + H2O = ADP + cholate(out) + H(+) + phosphate"}
{"X":48230,"RHEA_ID":56690,"compounds":"(2E)-3-(4-hydroxyphenyl)-2-isocyanoprop-2-enoate + CO2 + H2O + succinate => (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + O2"}
{"X":48231,"RHEA_ID":46660,"compounds":"H(+) + NADPH + progesterone = 5beta-pregnan-3,20-dione + NADP(+)"}
{"X":48232,"RHEA_ID":46661,"compounds":"H(+) + NADPH + progesterone => 5beta-pregnan-3,20-dione + NADP(+)"}
{"X":48233,"RHEA_ID":50052,"compounds":"ATP + H2O + taurocholate(in) = ADP + H(+) + phosphate + taurocholate(out)"}
{"X":48234,"RHEA_ID":56694,"compounds":"4-[(E)-2-isocyanoethenyl]phenol + 2 CO2 + H2O + succinate => (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2"}
{"X":48235,"RHEA_ID":46664,"compounds":"corticosterone + H(+) + NADPH = 5beta-dihydrocorticosterone + NADP(+)"}
{"X":48236,"RHEA_ID":46665,"compounds":"corticosterone + H(+) + NADPH => 5beta-dihydrocorticosterone + NADP(+)"}
{"X":48237,"RHEA_ID":50056,"compounds":"ATP + glycocholate(in) + H2O = ADP + glycocholate(out) + H(+) + phosphate"}
{"X":48238,"RHEA_ID":46667,"compounds":"corticosterone + H(+) + NADPH <=> 5beta-dihydrocorticosterone + NADP(+)"}
{"X":48239,"RHEA_ID":46668,"compounds":"21-hydroxyprogesterone + H(+) + NADPH = 5beta-dihydrodeoxycorticosterone + NADP(+)"}
{"X":48240,"RHEA_ID":46669,"compounds":"21-hydroxyprogesterone + H(+) + NADPH => 5beta-dihydrodeoxycorticosterone + NADP(+)"}
{"X":48241,"RHEA_ID":56701,"DIRECTION":"LR","MASTER_ID":56700,"metacyc":"RXN-19268","compounds":"(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 => 3-[(Z)-2-isocyanoethenyl]-1H-indole + 2 CO2 + H2O + succinate"}
{"X":48242,"RHEA_ID":56702,"compounds":"3-[(Z)-2-isocyanoethenyl]-1H-indole + 2 CO2 + H2O + succinate => (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2"}
{"X":48243,"RHEA_ID":46672,"compounds":"aldosterone + H(+) + NADPH = 5beta-dihydroaldosterone + NADP(+)"}
{"X":48244,"RHEA_ID":46673,"compounds":"aldosterone + H(+) + NADPH => 5beta-dihydroaldosterone + NADP(+)"}
{"X":48245,"RHEA_ID":46674,"compounds":"5beta-dihydroaldosterone + NADP(+) => aldosterone + H(+) + NADPH"}
{"X":48246,"RHEA_ID":56706,"compounds":"3-[(E)-2-isocyanovinyl]indole + 2 CO2 + H2O + succinate => (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2"}
{"X":48247,"RHEA_ID":46676,"compounds":"(4R)-hydroxy-(6R)-2,2,6-trimethylcyclohexanone + NAD(+) = (6R)-2,2,6-trimethyl-1,4-cyclohexanedione + H(+) + NADH"}
{"X":48248,"RHEA_ID":46677,"compounds":"(4R)-hydroxy-(6R)-2,2,6-trimethylcyclohexanone + NAD(+) => (6R)-2,2,6-trimethyl-1,4-cyclohexanedione + H(+) + NADH"}
{"X":48249,"RHEA_ID":56709,"DIRECTION":"LR","MASTER_ID":56708,"metacyc":"RXN-18956","compounds":"beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => 16alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":48250,"RHEA_ID":60118,"compounds":"CO2 + hydroxymethylphosphonate + succinate => 2-oxoglutarate + methylphosphonate + O2"}
{"X":48251,"RHEA_ID":46680,"DIRECTION":"UN","MASTER_ID":46680,"ec":"1.6.2.2","compounds":"2 [Fe(III)-cytochrome b5] + NADH = 2 [Fe(II)-cytochrome b5] + H(+) + NAD(+)"}
{"X":48252,"RHEA_ID":46681,"DIRECTION":"LR","MASTER_ID":46680,"metacyc":"CYTOCHROME-B5-REDUCTASE-RXN","compounds":"2 [Fe(III)-cytochrome b5] + NADH => 2 [Fe(II)-cytochrome b5] + H(+) + NAD(+)"}
{"X":48253,"RHEA_ID":56713,"DIRECTION":"LR","MASTER_ID":56712,"ecocyc":"RXN0-20","metacyc":"RXN0-20","compounds":"1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] => H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate"}
{"X":48254,"RHEA_ID":60122,"compounds":"H(+) + pre-sodorifen diphosphate + S-adenosyl-L-homocysteine => (2E,6E)-farnesyl diphosphate + S-adenosyl-L-methionine"}
{"X":48255,"RHEA_ID":46684,"compounds":"3-oxochol-4-en-24-oyl-CoA + A = (22E)-3-oxo-chol-4,22-dien-24-oyl-CoA + AH2"}
{"X":48256,"RHEA_ID":46685,"compounds":"3-oxochol-4-en-24-oyl-CoA + A => (22E)-3-oxo-chol-4,22-dien-24-oyl-CoA + AH2"}
{"X":48257,"RHEA_ID":56717,"DIRECTION":"LR","MASTER_ID":56716,"metacyc":"RXN-18797","compounds":"H2O + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein] => H(+) + S-disulfanyl-L-cysteinyl-[SoxY protein] + sulfate"}
{"X":48258,"RHEA_ID":60126,"compounds":"diphosphate + sodorifen => pre-sodorifen diphosphate"}
{"X":48259,"RHEA_ID":46688,"compounds":"(25S)-3-oxocholest-4-en-26-oyl-CoA + A = 3-oxo-cholest-4,24-dien-26-oyl-CoA + AH2"}
{"X":48260,"RHEA_ID":46689,"compounds":"(25S)-3-oxocholest-4-en-26-oyl-CoA + A => 3-oxo-cholest-4,24-dien-26-oyl-CoA + AH2"}
{"X":48261,"RHEA_ID":50080,"compounds":"ATP + H2O + taurodeoxycholate(in) = ADP + H(+) + phosphate + taurodeoxycholate(out)"}
{"X":48262,"RHEA_ID":60130,"compounds":"17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + H(+) + phosphate => 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O"}
{"X":48263,"RHEA_ID":46692,"compounds":"4-hydroxybenzoate + ATP + H(+) = 4-hydroxybenzoyl-5'-AMP + diphosphate"}
{"X":48264,"RHEA_ID":46693,"compounds":"4-hydroxybenzoate + ATP + H(+) => 4-hydroxybenzoyl-5'-AMP + diphosphate"}
{"X":48265,"RHEA_ID":56725,"DIRECTION":"LR","MASTER_ID":56724,"metacyc":"RXN-16413","compounds":"AH2 + all-trans-beta-carotene + O2 => 4-hydroxy-all-trans-beta-carotene + A + H2O"}
{"X":48266,"RHEA_ID":60134,"compounds":"a (8S,9S)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate => a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2"}
{"X":48267,"RHEA_ID":46696,"DIRECTION":"UN","MASTER_ID":46696,"ec":"2.1.1.260","compounds":"a pseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine = an N(1)-methylpseudouridine in 16S/18S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":48268,"RHEA_ID":46697,"compounds":"a pseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine => an N(1)-methylpseudouridine in 16S/18S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":48269,"RHEA_ID":56729,"DIRECTION":"LR","MASTER_ID":56728,"metacyc":"RXN-18957","compounds":"4-hydroxy-all-trans-beta-carotene + AH2 + O2 => 4,4-dihydroxy-all-trans-beta-carotene + A + H2O"}
{"X":48270,"RHEA_ID":60138,"compounds":"a (8S,9R)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate => a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2"}
{"X":48271,"RHEA_ID":46700,"compounds":"(R)-lipoate + GTP + H(+) = (R)-lipoyl-GMP + diphosphate"}
{"X":48272,"RHEA_ID":46701,"compounds":"(R)-lipoate + GTP + H(+) => (R)-lipoyl-GMP + diphosphate"}
{"X":48273,"RHEA_ID":46702,"compounds":"(R)-lipoyl-GMP + diphosphate => (R)-lipoate + GTP + H(+)"}
{"X":48274,"RHEA_ID":50093,"compounds":"a fatty acyl-CoA + taurine => an N-fatty acyl-taurine + CoA + H(+)"}
{"X":48275,"RHEA_ID":46704,"compounds":"ATP + H(+) + salicylate = 2-hydroxybenzoyl-5'-AMP + diphosphate"}
{"X":48276,"RHEA_ID":46705,"DIRECTION":"LR","MASTER_ID":46704,"metacyc":"RXN-11113","compounds":"ATP + H(+) + salicylate => 2-hydroxybenzoyl-5'-AMP + diphosphate"}
{"X":48277,"RHEA_ID":46706,"compounds":"2-hydroxybenzoyl-5'-AMP + diphosphate => ATP + H(+) + salicylate"}
{"X":48278,"RHEA_ID":56738,"compounds":"H(+) + H2O2 + retinoate => H2O + O2 + retinal"}
{"X":48279,"RHEA_ID":46708,"compounds":"2-hydroxybenzoyl-5'-AMP + holo-[ACP] = AMP + H(+) + salicyl-[ACP]"}
{"X":48280,"RHEA_ID":46709,"DIRECTION":"LR","MASTER_ID":46708,"metacyc":"RXN-19444","compounds":"2-hydroxybenzoyl-5'-AMP + holo-[ACP] => AMP + H(+) + salicyl-[ACP]"}
{"X":48281,"RHEA_ID":50100,"compounds":"dodecanoyl-CoA + taurine = CoA + H(+) + N-dodecanoyl-taurine"}
{"X":48282,"RHEA_ID":56742,"compounds":"GalGb3Cer + H(+) + UDP => globoside Gb3Cer + UDP-alpha-D-galactose"}
{"X":48283,"RHEA_ID":46712,"DIRECTION":"UN","MASTER_ID":46712,"ec":"2.1.1.260","compounds":"pseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-homocysteine"}
{"X":48284,"RHEA_ID":46713,"compounds":"pseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-homocysteine"}
{"X":48285,"RHEA_ID":46714,"compounds":"H(+) + N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-homocysteine => pseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine"}
{"X":48286,"RHEA_ID":56746,"compounds":"(3R)-3-hydroxy-L-arginyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-arginyl-[protein] + O2"}
{"X":48287,"RHEA_ID":50106,"compounds":"CoA + H(+) + N-tetradecanoyl-taurine => taurine + tetradecanoyl-CoA"}
{"X":48288,"RHEA_ID":46717,"DIRECTION":"LR","MASTER_ID":46716,"metacyc":"RXN-13327","compounds":"pseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylpseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-homocysteine"}
{"X":48289,"RHEA_ID":56749,"DIRECTION":"LR","MASTER_ID":56748,"metacyc":"RXN-16394","compounds":"an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => an omega-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":48290,"RHEA_ID":56750,"compounds":"an omega-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":48291,"RHEA_ID":50110,"compounds":"CoA + H(+) + N-hexadecanoyl-taurine => hexadecanoyl-CoA + taurine"}
{"X":48292,"RHEA_ID":46721,"compounds":"(3R)-hydroxyhexanoyl-CoA => (2E)-hexenoyl-CoA + H2O"}
{"X":48293,"RHEA_ID":56753,"DIRECTION":"LR","MASTER_ID":56752,"metacyc":"RXN-20136","compounds":"a 14alpha-methyl steroid + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => a Delta(14) steroid + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":48294,"RHEA_ID":56754,"compounds":"a Delta(14) steroid + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => a 14alpha-methyl steroid + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]"}
{"X":48295,"RHEA_ID":50114,"compounds":"CoA + H(+) + N-octadecanoyl-taurine => octadecanoyl-CoA + taurine"}
{"X":48296,"RHEA_ID":46725,"compounds":"(2S)-2-methyltetradecanoyl-CoA => (2R)-2-methyltetradecanoyl-CoA"}
{"X":48297,"RHEA_ID":46726,"compounds":"(2R)-2-methyltetradecanoyl-CoA => (2S)-2-methyltetradecanoyl-CoA"}
{"X":48298,"RHEA_ID":56758,"compounds":"4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => 5 H(+) + 3 O2 + obtusifoliol + 6 reduced [2Fe-2S]-[ferredoxin]"}
{"X":48299,"RHEA_ID":60167,"compounds":"a guanosine in RNA + S-adenosyl-L-methionine <=> an N(7)-methylguanosine in RNA + S-adenosyl-L-homocysteine"}
{"X":48300,"RHEA_ID":46729,"compounds":"(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + O2 => (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O2"}
{"X":48301,"RHEA_ID":56761,"compounds":"24,25-dihydrolanosterol + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":48302,"RHEA_ID":56762,"compounds":"4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => 24,25-dihydrolanosterol + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]"}
{"X":48303,"RHEA_ID":60183,"compounds":"ATP + D-fructose(out) + H2O <=> ADP + D-fructose(in) + H(+) + phosphate"}
{"X":48304,"RHEA_ID":46733,"compounds":"(2R,6)-dimethylheptanoyl-CoA => (2S,6)-dimethylheptanoyl-CoA"}
{"X":48305,"RHEA_ID":56765,"DIRECTION":"LR","MASTER_ID":56764,"metacyc":"RXN-19283","compounds":"12-epi-fischerindole U + 2-oxoglutarate + chloride + H(+) + O2 => 12-epi-fischerindole G + CO2 + H2O + succinate"}
{"X":48306,"RHEA_ID":56766,"compounds":"12-epi-fischerindole G + CO2 + H2O + succinate => 12-epi-fischerindole U + 2-oxoglutarate + chloride + H(+) + O2"}
{"X":48307,"RHEA_ID":60187,"compounds":"ATP + D-glucose(out) + H2O <=> ADP + D-glucose(in) + H(+) + phosphate"}
{"X":48308,"RHEA_ID":46737,"compounds":"H2O + monoacyl-sn-glycero-3-phosphate => a monoacylglycerol + phosphate"}
{"X":48309,"RHEA_ID":56769,"DIRECTION":"LR","MASTER_ID":56768,"metacyc":"RXN-8189","compounds":"2 AH2 + all-trans-zeaxanthin + 2 O2 => 2 A + all-trans-adonixanthin + 3 H2O"}
{"X":48310,"RHEA_ID":56770,"compounds":"2 A + all-trans-adonixanthin + 3 H2O => 2 AH2 + all-trans-zeaxanthin + 2 O2"}
{"X":48311,"RHEA_ID":60191,"compounds":"2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 O2 <=> 2 CO2 + 2 formaldehyde + L-lysyl(9)-[histone H3] + 2 succinate"}
{"X":48312,"RHEA_ID":46741,"compounds":"cholesta-5,7,24-trien-3beta-ol + H(+) + NADPH => cholesta-5,24-dien-3beta-ol + NADP(+)"}
{"X":48313,"RHEA_ID":46742,"compounds":"cholesta-5,24-dien-3beta-ol + NADP(+) => cholesta-5,7,24-trien-3beta-ol + H(+) + NADPH"}
{"X":48314,"RHEA_ID":56774,"compounds":"2 A + all-trans-(3S,3'S)-astaxanthin + 3 H2O => 2 AH2 + all-trans-adonixanthin + 2 O2"}
{"X":48315,"RHEA_ID":46744,"compounds":"ATP + hydrogencarbonate = ADP + carboxyphosphate"}
{"X":48316,"RHEA_ID":46745,"DIRECTION":"LR","MASTER_ID":46744,"ecocyc":"RXN-16909","metacyc":"RXN-16909","compounds":"ATP + hydrogencarbonate => ADP + carboxyphosphate"}
{"X":48317,"RHEA_ID":46746,"compounds":"ADP + carboxyphosphate => ATP + hydrogencarbonate"}
{"X":48318,"RHEA_ID":60198,"compounds":"CO2 + formaldehyde + L-lysyl(9)-[histone H3] + succinate => 2-oxoglutarate + N(6)-methyl-L-lysyl(9)-[histone H3] + O2"}
{"X":48319,"RHEA_ID":46748,"compounds":"carboxyphosphate + NH4(+) = carbamate + 2 H(+) + phosphate"}
{"X":48320,"RHEA_ID":46749,"DIRECTION":"LR","MASTER_ID":46748,"ecocyc":"RXN-16910","metacyc":"RXN-16910","compounds":"carboxyphosphate + NH4(+) => carbamate + 2 H(+) + phosphate"}
{"X":48321,"RHEA_ID":46750,"compounds":"carbamate + 2 H(+) + phosphate => carboxyphosphate + NH4(+)"}
{"X":48322,"RHEA_ID":50141,"compounds":"(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => (14S,15S)-epoxy-(5Z,8Z,10E,12E)-eicosatetraenoate + H2O"}
{"X":48323,"RHEA_ID":46752,"DIRECTION":"UN","MASTER_ID":46752,"ec":"1.14.18.8","compounds":"7alpha-hydroxycholest-4-en-3-one + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 7alpha,12alpha-dihydroxycholest-4-en-3-one + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":48324,"RHEA_ID":46753,"DIRECTION":"LR","MASTER_ID":46752,"metacyc":"1.14.13.95-RXN","compounds":"7alpha-hydroxycholest-4-en-3-one + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 7alpha,12alpha-dihydroxycholest-4-en-3-one + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":48325,"RHEA_ID":50144,"compounds":"ethyl (9Z)-hexadecenoate + H2O = (9Z)-hexadecenoate + ethanol + H(+)"}
{"X":48326,"RHEA_ID":50145,"compounds":"ethyl (9Z)-hexadecenoate + H2O => (9Z)-hexadecenoate + ethanol + H(+)"}
{"X":48327,"RHEA_ID":46756,"DIRECTION":"UN","MASTER_ID":46756,"ec":"1.14.19.42","compounds":"a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-acyl-2-[(7Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":48328,"RHEA_ID":46757,"DIRECTION":"LR","MASTER_ID":46756,"metacyc":"RXN-16048","compounds":"a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-acyl-2-[(7Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":48329,"RHEA_ID":46758,"compounds":"a 1-acyl-2-[(7Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":48330,"RHEA_ID":46759,"compounds":"a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-acyl-2-[(7Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":48331,"RHEA_ID":46760,"DIRECTION":"UN","MASTER_ID":46760,"ec":"1.14.12.24","compounds":"2,4-dinitrotoluene + NADH + O2 = 4-methyl-5-nitrocatechol + NAD(+) + nitrite"}
{"X":48332,"RHEA_ID":46761,"DIRECTION":"LR","MASTER_ID":46760,"metacyc":"RXN-8820","compounds":"2,4-dinitrotoluene + NADH + O2 => 4-methyl-5-nitrocatechol + NAD(+) + nitrite"}
{"X":48333,"RHEA_ID":50152,"compounds":"(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O"}
{"X":48334,"RHEA_ID":50153,"compounds":"(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O"}
{"X":48335,"RHEA_ID":46764,"DIRECTION":"UN","MASTER_ID":46764,"ec":"1.14.19.43","compounds":"a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-acyl-2-[(3E)-hexadec-3-enoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":48336,"RHEA_ID":46765,"DIRECTION":"LR","MASTER_ID":46764,"metacyc":"RXN-16053","compounds":"a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-acyl-2-[(3E)-hexadec-3-enoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":48337,"RHEA_ID":46766,"compounds":"a 1-acyl-2-[(3E)-hexadec-3-enoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":48338,"RHEA_ID":50157,"compounds":"N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 => N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-taurine"}
{"X":48339,"RHEA_ID":46768,"DIRECTION":"UN","MASTER_ID":46768,"ec":"1.14.19.27","metacyc":"RXN-16388","compounds":"a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-acyl-2-[(9Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":48340,"RHEA_ID":46768,"DIRECTION":"UN","MASTER_ID":46768,"ec":"1.14.19.27","metacyc":"RXN-16382","compounds":"a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-acyl-2-[(9Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":48341,"RHEA_ID":46769,"compounds":"a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-acyl-2-[(9Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":48342,"RHEA_ID":50161,"compounds":"N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 => N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-taurine"}
{"X":48343,"RHEA_ID":46771,"compounds":"a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-acyl-2-[(9Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":48344,"RHEA_ID":46772,"DIRECTION":"UN","MASTER_ID":46772,"ec":"1.14.19.28","metacyc":"RXN-16387","compounds":"1-octadecanoyl 2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":48345,"RHEA_ID":46773,"compounds":"1-octadecanoyl 2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":48346,"RHEA_ID":50165,"compounds":"(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":48347,"RHEA_ID":46775,"compounds":"1-octadecanoyl 2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":48348,"RHEA_ID":46776,"DIRECTION":"UN","MASTER_ID":46776,"ec":"1.14.19.45","compounds":"a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":48349,"RHEA_ID":46777,"compounds":"a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":48350,"RHEA_ID":56810,"compounds":"adenosylcob(III)yrinate a,c-diamide + apo-[corrinoid adenosyltransferase] + triphosphate => ATP + cob(I)yrinate a,c diamide--[corrinoid adenosyltransferase]"}
{"X":48351,"RHEA_ID":46779,"DIRECTION":"BI","MASTER_ID":46776,"metacyc":"RXN-16386","compounds":"a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":48352,"RHEA_ID":46780,"DIRECTION":"UN","MASTER_ID":46780,"ec":"1.14.19.46","compounds":"a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":48353,"RHEA_ID":46781,"compounds":"a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":48354,"RHEA_ID":50173,"compounds":"N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 => N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-alanine"}
{"X":48355,"RHEA_ID":46783,"DIRECTION":"BI","MASTER_ID":46780,"metacyc":"RXN-16385","compounds":"a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":48356,"RHEA_ID":46784,"DIRECTION":"UN","MASTER_ID":46784,"ec":"1.14.19.36","compounds":"a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-[(9Z,12Z,15Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":48357,"RHEA_ID":60237,"DIRECTION":"LR","MASTER_ID":60236,"metacyc":"RXN-20643","compounds":"2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 2 O2 => 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + 2 succinate"}
{"X":48358,"RHEA_ID":56818,"compounds":"a pyrimidine nucleobase + D-ribose => a pyrimidine ribonucleoside + H2O"}
{"X":48359,"RHEA_ID":46787,"compounds":"a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-[(9Z,12Z,15Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":48360,"RHEA_ID":46788,"DIRECTION":"UN","MASTER_ID":46788,"ec":"1.14.19.36","compounds":"a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-[(6Z,9Z,12Z,15Z)-octadectetraenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":48361,"RHEA_ID":46789,"DIRECTION":"LR","MASTER_ID":46788,"metacyc":"RXN-16070","compounds":"a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-[(6Z,9Z,12Z,15Z)-octadectetraenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":48362,"RHEA_ID":56822,"compounds":"A + cyclooctat-9-ene-5,7-diol + H2O => AH2 + cyclooctat-9-en-7-ol + O2"}
{"X":48363,"RHEA_ID":50182,"compounds":"N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-gamma-aminobutanoate => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2"}
{"X":48364,"RHEA_ID":46792,"DIRECTION":"UN","MASTER_ID":46792,"ec":"1.14.19.4","compounds":"2 [Fe(II)-cytochrome b5] + an (11Z,14Z)-icosadienoyl-containing glycerolipid + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 H2O"}
{"X":48365,"RHEA_ID":60245,"DIRECTION":"LR","MASTER_ID":60244,"metacyc":"RXN-20644","compounds":"2 A + 2 H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] => 2 AH2 + 2 formaldehyde + L-lysyl(4)-[histone H3]"}
{"X":48366,"RHEA_ID":60246,"compounds":"2 AH2 + 2 formaldehyde + L-lysyl(4)-[histone H3] => 2 A + 2 H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3]"}
{"X":48367,"RHEA_ID":46795,"compounds":"2 [Fe(II)-cytochrome b5] + an (11Z,14Z)-icosadienoyl-containing glycerolipid + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 H2O"}
{"X":48368,"RHEA_ID":46796,"DIRECTION":"UN","MASTER_ID":46796,"ec":"1.14.19.4","compounds":"2 [Fe(II)-cytochrome b5] + an (11Z,14Z,17Z)-icosatrienoyl-containing glycerolipid + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 H2O"}
{"X":48369,"RHEA_ID":60249,"DIRECTION":"LR","MASTER_ID":60248,"metacyc":"RXN66-607","compounds":"A + H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] => AH2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3]"}
{"X":48370,"RHEA_ID":56830,"DIRECTION":"RL","MASTER_ID":56828,"metacyc":"TECH1REDHAL-RXN","compounds":"2,3,5,6-tetrachlorohydroquinone + 2 glutathione => 2,3,6-trichlorohydroquinone + chloride + glutathione disulfide"}
{"X":48371,"RHEA_ID":46799,"compounds":"2 [Fe(II)-cytochrome b5] + an (11Z,14Z,17Z)-icosatrienoyl-containing glycerolipid + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 H2O"}
{"X":48372,"RHEA_ID":46800,"DIRECTION":"UN","MASTER_ID":46800,"ec":"7.2.1.2","compounds":"H(+) + Na(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = Na(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":48373,"RHEA_ID":60253,"compounds":"(S)-methylmalonyl-CoA + NADP(+) => acryloyl-CoA + CO2 + NADPH"}
{"X":48374,"RHEA_ID":60254,"compounds":"acryloyl-CoA + CO2 + NADPH => (S)-methylmalonyl-CoA + NADP(+)"}
{"X":48375,"RHEA_ID":46803,"compounds":"H(+) + Na(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> Na(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":48376,"RHEA_ID":46804,"DIRECTION":"UN","MASTER_ID":46804,"ec":"2.1.1.317","compounds":"a (4E,8E)-4-sphinga-4,8-dienine ceramide + S-adenosyl-L-methionine = a 9-methyl-(4E,8E)-sphinga-4,8-dienine ceramide + H(+) + S-adenosyl-L-homocysteine"}
{"X":48377,"RHEA_ID":53502,"compounds":"1-hexanoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+) => 1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O"}
{"X":48378,"RHEA_ID":50197,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 => (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O"}
{"X":48379,"RHEA_ID":56839,"compounds":"[PQQ precursor protein] + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + E-Y cross-linked-[PQQ precursor protein] + H(+) + L-methionine"}
{"X":48380,"RHEA_ID":50199,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 <=> (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O"}
{"X":48381,"RHEA_ID":53506,"compounds":"5'-deoxyadenosine + 5-hydroxybenzimidazole + A + formate + 2 H(+) + L-methionine + NH4(+) + phosphate => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + AH2 + S-adenosyl-L-methionine"}
{"X":48382,"RHEA_ID":50201,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 => (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O"}
{"X":48383,"RHEA_ID":50202,"compounds":"(18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2"}
{"X":48384,"RHEA_ID":46812,"compounds":"4,4-dimethyl-8,14-cholestadien-3beta-ol + H(+) + NADPH = 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)"}
{"X":48385,"RHEA_ID":60265,"DIRECTION":"LR","MASTER_ID":60264,"metacyc":"RXN-20598","compounds":"L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":48386,"RHEA_ID":50205,"DIRECTION":"LR","MASTER_ID":50204,"reactome":"R-HSA-9018858.1","compounds":"(18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 => (5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate"}
{"X":48387,"RHEA_ID":46815,"compounds":"4,4-dimethyl-8,14-cholestadien-3beta-ol + H(+) + NADPH <=> 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)"}
{"X":48388,"RHEA_ID":46816,"compounds":"4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":48389,"RHEA_ID":60269,"DIRECTION":"LR","MASTER_ID":60268,"metacyc":"RXN-20604","compounds":"N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":48390,"RHEA_ID":56850,"compounds":"H(+) + reumycin + S-adenosyl-L-homocysteine => 1,6-didemethyltoxoflavin + S-adenosyl-L-methionine"}
{"X":48391,"RHEA_ID":50210,"compounds":"cortisone + H(+) + NADH => cortisol + NAD(+)"}
{"X":48392,"RHEA_ID":46820,"compounds":"4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":48393,"RHEA_ID":50212,"compounds":"(13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 11-hydroxy-(12S,13S)-epoxy-(9Z)-octadecenoate"}
{"X":48394,"RHEA_ID":56854,"compounds":"H(+) + S-adenosyl-L-homocysteine + toxoflavin => reumycin + S-adenosyl-L-methionine"}
{"X":48395,"RHEA_ID":46823,"compounds":"4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":48396,"RHEA_ID":46824,"compounds":"4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 = 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":48397,"RHEA_ID":60277,"DIRECTION":"LR","MASTER_ID":60276,"metacyc":"RXN-20617","compounds":"L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine"}
{"X":48398,"RHEA_ID":46826,"compounds":"4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O => 4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2"}
{"X":48399,"RHEA_ID":46827,"compounds":"4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":48400,"RHEA_ID":46828,"compounds":"4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADPH"}
{"X":48401,"RHEA_ID":46829,"compounds":"4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+) => 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADPH"}
{"X":48402,"RHEA_ID":56861,"DIRECTION":"LR","MASTER_ID":56860,"metacyc":"RXN-18648","compounds":"a medium-chain 3-oxoacyl-[ACP] + dihydroxyacetone phosphate => a 2-oxo-3-(phosphooxy)propyl medium-chain 3-oxoalkanoate + holo-[ACP]"}
{"X":48403,"RHEA_ID":46831,"compounds":"4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+) <=> 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADPH"}
{"X":48404,"RHEA_ID":46832,"compounds":"4alpha-methyl-5alpha-cholest-8-en-3-one + H(+) + NADPH = 4alpha-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+)"}
{"X":48405,"RHEA_ID":46833,"compounds":"4alpha-methyl-5alpha-cholest-8-en-3-one + H(+) + NADPH => 4alpha-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+)"}
{"X":48406,"RHEA_ID":50225,"compounds":"3-(all-trans-hexaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine => 2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine"}
{"X":48407,"RHEA_ID":46835,"compounds":"4alpha-methyl-5alpha-cholest-8-en-3-one + H(+) + NADPH <=> 4alpha-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+)"}
{"X":48408,"RHEA_ID":46836,"compounds":"4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":48409,"RHEA_ID":60289,"DIRECTION":"LR","MASTER_ID":60288,"metacyc":"RXN-20611","compounds":"N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":48410,"RHEA_ID":50229,"DIRECTION":"LR","MASTER_ID":50228,"metacyc":"R307-RXN","compounds":"FADH2 + O2 + resorcinol => benzene-1,2,4-triol + FAD + H(+) + H2O"}
{"X":48411,"RHEA_ID":46839,"compounds":"4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":48412,"RHEA_ID":46840,"compounds":"4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":48413,"RHEA_ID":50232,"DIRECTION":"UN","MASTER_ID":50232,"ec":"1.14.15.20","compounds":"8 H(+) + heme b + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] = biliverdin IXalpha + CO + Fe(2+) + 3 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":48414,"RHEA_ID":46842,"compounds":"4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}
{"X":48415,"RHEA_ID":46843,"compounds":"4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":48416,"RHEA_ID":46844,"compounds":"4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 = 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":48417,"RHEA_ID":46845,"compounds":"4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 => 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":48418,"RHEA_ID":56877,"compounds":"(R)-N-acetyl-1-phenylethylamine + H2O => (R)-1-phenylethylamine + acetate"}
{"X":48419,"RHEA_ID":46847,"compounds":"4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":48420,"RHEA_ID":46848,"compounds":"4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NADP(+) = 5alpha-cholest-8-en-3-one + CO2 + NADPH"}
{"X":48421,"RHEA_ID":46849,"compounds":"4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NADP(+) => 5alpha-cholest-8-en-3-one + CO2 + NADPH"}
{"X":48422,"RHEA_ID":60302,"compounds":"H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine"}
{"X":48423,"RHEA_ID":46851,"compounds":"4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NADP(+) <=> 5alpha-cholest-8-en-3-one + CO2 + NADPH"}
{"X":48424,"RHEA_ID":46852,"compounds":"5alpha-cholest-8-en-3-one + H(+) + NADPH = 5alpha-cholest-8-en-3beta-ol + NADP(+)"}
{"X":48425,"RHEA_ID":46853,"compounds":"5alpha-cholest-8-en-3-one + H(+) + NADPH => 5alpha-cholest-8-en-3beta-ol + NADP(+)"}
{"X":48426,"RHEA_ID":60306,"compounds":"H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine"}
{"X":48427,"RHEA_ID":46855,"compounds":"5alpha-cholest-8-en-3-one + H(+) + NADPH <=> 5alpha-cholest-8-en-3beta-ol + NADP(+)"}
{"X":48428,"RHEA_ID":46856,"compounds":"4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADPH = 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)"}
{"X":48429,"RHEA_ID":46857,"compounds":"4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADPH => 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)"}
{"X":48430,"RHEA_ID":50248,"DIRECTION":"UN","MASTER_ID":50248,"ec":"2.7.7.96","compounds":"ATP + D-ribose 5-phosphate + H(+) = ADP-D-ribose + diphosphate"}
{"X":48431,"RHEA_ID":46859,"compounds":"4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADPH <=> 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)"}
{"X":48432,"RHEA_ID":46864,"DIRECTION":"UN","MASTER_ID":46864,"ec":"2.3.1.251","compounds":"1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid A (E. coli) = a 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A"}
{"X":48433,"RHEA_ID":46865,"DIRECTION":"LR","MASTER_ID":46864,"ecocyc":"RXN0-1842","metacyc":"RXN0-1842","compounds":"1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid A (E. coli) => a 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A"}
{"X":48434,"RHEA_ID":56893,"DIRECTION":"LR","MASTER_ID":56892,"metacyc":"RXN-10740","compounds":"H(+) + NADPH + UDP-4-dehydro-beta-L-rhamnose => NADP(+) + UDP-beta-L-rhamnose"}
{"X":48435,"RHEA_ID":46867,"compounds":"1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid A (E. coli) <=> a 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A"}
{"X":48436,"RHEA_ID":46868,"DIRECTION":"UN","MASTER_ID":46868,"ec":"2.3.1.251","compounds":"1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA (E. coli) = a 2-acyl-sn-glycero-3-phosphocholine + lipid IVB"}
{"X":48437,"RHEA_ID":60317,"DIRECTION":"LR","MASTER_ID":60316,"metacyc":"RXN-20607","compounds":"N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":48438,"RHEA_ID":46870,"compounds":"a 2-acyl-sn-glycero-3-phosphocholine + lipid IVB => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA (E. coli)"}
{"X":48439,"RHEA_ID":46871,"DIRECTION":"BI","MASTER_ID":46868,"metacyc":"RXN-16275","compounds":"1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA (E. coli) <=> a 2-acyl-sn-glycero-3-phosphocholine + lipid IVB"}
{"X":48440,"RHEA_ID":61633,"DIRECTION":"LR","MASTER_ID":61632,"ecocyc":"RXN0-7318","metacyc":"RXN0-7318","compounds":"5-aminopentanal + H2O + NAD(+) => 5-aminopentanoate + 2 H(+) + NADH"}
{"X":48441,"RHEA_ID":46873,"compounds":"1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IIA => a 2-acyl-sn-glycero-3-phosphocholine + lipid IIB"}
{"X":48442,"RHEA_ID":46874,"compounds":"a 2-acyl-sn-glycero-3-phosphocholine + lipid IIB => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IIA"}
{"X":48443,"RHEA_ID":46875,"DIRECTION":"BI","MASTER_ID":46872,"metacyc":"RXN-16274","compounds":"1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IIA <=> a 2-acyl-sn-glycero-3-phosphocholine + lipid IIB"}
{"X":48444,"RHEA_ID":46876,"DIRECTION":"UN","MASTER_ID":46876,"ec":"2.4.1.33","compounds":"[(1->4)-beta-D-mannuronosyl](n) + GDP-alpha-D-mannuronate = [(1->4)-beta-D-mannuronosyl](n+1) + GDP + H(+)"}
{"X":48445,"RHEA_ID":46877,"compounds":"[(1->4)-beta-D-mannuronosyl](n) + GDP-alpha-D-mannuronate => [(1->4)-beta-D-mannuronosyl](n+1) + GDP + H(+)"}
{"X":48446,"RHEA_ID":56905,"compounds":"an acyl-AMP + CoA => AMP + an acyl-CoA + H(+)"}
{"X":48447,"RHEA_ID":50265,"compounds":"cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 26-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":48448,"RHEA_ID":46880,"DIRECTION":"UN","MASTER_ID":46880,"ec":"2.4.1.147","compounds":"3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP"}
{"X":48449,"RHEA_ID":50267,"compounds":"cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 26-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":48450,"RHEA_ID":60330,"compounds":"3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine => L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine"}
{"X":48451,"RHEA_ID":56910,"compounds":"acetate + H(+) + thebaine => (7S)-O-acetylsalutaridinol"}
{"X":48452,"RHEA_ID":46884,"DIRECTION":"UN","MASTER_ID":46884,"ec":"2.4.1.147","compounds":"3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP"}
{"X":48453,"RHEA_ID":60333,"DIRECTION":"LR","MASTER_ID":60332,"metacyc":"RXN-20602","compounds":"L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":48454,"RHEA_ID":46886,"compounds":"3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":48455,"RHEA_ID":56914,"compounds":"(E)-2-((N-methylformamido) methylene)succinate + 3 H(+) + NADH => (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + H2O + NAD(+)"}
{"X":48456,"RHEA_ID":46888,"DIRECTION":"UN","MASTER_ID":46888,"ec":"1.1.3.48","compounds":"3-deoxy-alpha-D-manno-oct-2-ulosonate + O2 = 3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + H2O2"}
{"X":48457,"RHEA_ID":46889,"DIRECTION":"LR","MASTER_ID":46888,"metacyc":"RXN-16746","compounds":"3-deoxy-alpha-D-manno-oct-2-ulosonate + O2 => 3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + H2O2"}
{"X":48458,"RHEA_ID":56917,"compounds":"3beta-hydroxy-5alpha-androstan-17-one + NADP(+) => 5alpha-androstan-3,17-dione + H(+) + NADPH"}
{"X":48459,"RHEA_ID":56918,"compounds":"5alpha-androstan-3,17-dione + H(+) + NADPH => 3beta-hydroxy-5alpha-androstan-17-one + NADP(+)"}
{"X":48460,"RHEA_ID":46892,"DIRECTION":"UN","MASTER_ID":46892,"ec":"2.6.1.109","compounds":"2-oxoglutarate + 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate = 3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + L-glutamate"}
{"X":48461,"RHEA_ID":46893,"compounds":"2-oxoglutarate + 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate => 3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + L-glutamate"}
{"X":48462,"RHEA_ID":56921,"compounds":"a medium chain fatty acid + ATP + H(+) => a medium-chain fatty acyl-AMP + diphosphate"}
{"X":48463,"RHEA_ID":56922,"compounds":"a medium-chain fatty acyl-AMP + diphosphate => a medium chain fatty acid + ATP + H(+)"}
{"X":48464,"RHEA_ID":46896,"DIRECTION":"UN","MASTER_ID":46896,"ec":"2.7.8.43","compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli) = a 1,2-diacyl-sn-glycerol + lipid A hexaacyl 1-(2-aminoethyl diphosphate)"}
{"X":48465,"RHEA_ID":46897,"DIRECTION":"LR","MASTER_ID":46896,"metacyc":"RXN-16283","compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli) => a 1,2-diacyl-sn-glycerol + lipid A hexaacyl 1-(2-aminoethyl diphosphate)"}
{"X":48466,"RHEA_ID":56925,"compounds":"ATP + L-threonyl-[Goodpasture antigen-binding protein] => ADP + H(+) + O-phospho-L-threonyl-[Goodpasture antigen-binding protein]"}
{"X":48467,"RHEA_ID":56926,"compounds":"ADP + H(+) + O-phospho-L-threonyl-[Goodpasture antigen-binding protein] => ATP + L-threonyl-[Goodpasture antigen-binding protein]"}
{"X":48468,"RHEA_ID":46900,"DIRECTION":"UN","MASTER_ID":46900,"ec":"2.7.8.43","compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli) = a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate) (E. coli)"}
{"X":48469,"RHEA_ID":46901,"DIRECTION":"LR","MASTER_ID":46900,"metacyc":"RXN-16282","compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli) => a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate) (E. coli)"}
{"X":48470,"RHEA_ID":56929,"DIRECTION":"LR","MASTER_ID":56928,"metacyc":"RXN-8510","compounds":"abieta-7,13-dien-18-al + O2 + reduced [NADPH--hemoprotein reductase] => abieta-7,13-dien-18-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":48471,"RHEA_ID":56930,"compounds":"abieta-7,13-dien-18-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => abieta-7,13-dien-18-al + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":48472,"RHEA_ID":46904,"DIRECTION":"UN","MASTER_ID":46904,"ec":"2.7.8.43","compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A hexaacyl 1-(2-aminoethyl diphosphate) = a 1,2-diacyl-sn-glycerol + lipid A 1,4'-bis(2-aminoethyl diphosphate)"}
{"X":48473,"RHEA_ID":60353,"compounds":"2-heptyl-3-hydroxy-4(1H)-quinolone + O2 => CO + H(+) + N-octanoylanthranilate"}
{"X":48474,"RHEA_ID":56933,"compounds":"androst-5-en-3beta,17beta-diol + NAD(+) => 17beta-hydroxy-androst-5-en-3-one + H(+) + NADH"}
{"X":48475,"RHEA_ID":46908,"DIRECTION":"UN","MASTER_ID":46908,"ec":"2.7.8.42","compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA = 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + a 1,2-diacyl-sn-glycerol"}
{"X":48476,"RHEA_ID":50295,"compounds":"all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> all-trans-3,4-didehydroretinol + 2 H2O + 2 oxidized [adrenodoxin]"}
{"X":48477,"RHEA_ID":56937,"compounds":"17beta-hydroxy-androst-5-en-3-one => testosterone"}
{"X":48478,"RHEA_ID":56938,"compounds":"testosterone => 17beta-hydroxy-androst-5-en-3-one"}
{"X":48479,"RHEA_ID":46912,"DIRECTION":"UN","MASTER_ID":46912,"ec":"3.1.1.59","compounds":"H2O + juvenile hormone III = H(+) + juvenile hormone III carboxylate + methanol"}
{"X":48480,"RHEA_ID":46913,"DIRECTION":"LR","MASTER_ID":46912,"metacyc":"JUVENILE-HORMONE-ESTERASE-RXN","compounds":"H2O + juvenile hormone III => H(+) + juvenile hormone III carboxylate + methanol"}
{"X":48481,"RHEA_ID":56941,"compounds":"5-methylsulfanyl-D-ribulose 1-phosphate => 2-(methylthio)acetaldehyde + dihydroxyacetone phosphate"}
{"X":48482,"RHEA_ID":56942,"compounds":"2-(methylthio)acetaldehyde + dihydroxyacetone phosphate => 5-methylsulfanyl-D-ribulose 1-phosphate"}
{"X":48483,"RHEA_ID":46916,"DIRECTION":"UN","MASTER_ID":46916,"ec":"3.1.1.59","compounds":"H2O + juvenile hormone I = H(+) + juvenile hormone I carboxylate + methanol"}
{"X":48484,"RHEA_ID":46917,"compounds":"H2O + juvenile hormone I => H(+) + juvenile hormone I carboxylate + methanol"}
{"X":48485,"RHEA_ID":46918,"compounds":"H(+) + juvenile hormone I carboxylate + methanol => H2O + juvenile hormone I"}
{"X":48486,"RHEA_ID":56946,"compounds":"1-deoxy-D-xylulose 5-phosphate + A + H2O => AH2 + D-ribulose 5-phosphate"}
{"X":48487,"RHEA_ID":46920,"DIRECTION":"UN","MASTER_ID":46920,"ec":"4.1.1.102","compounds":"H(+) + trans-cinnamate = CO2 + styrene"}
{"X":48488,"RHEA_ID":46921,"compounds":"H(+) + trans-cinnamate => CO2 + styrene"}
{"X":48489,"RHEA_ID":46922,"compounds":"CO2 + styrene => H(+) + trans-cinnamate"}
{"X":48490,"RHEA_ID":60371,"compounds":"urate(out) <=> urate(in)"}
{"X":48491,"RHEA_ID":46924,"DIRECTION":"UN","MASTER_ID":46924,"ec":"4.2.1.157","compounds":"(R)-2-hydroxy-4-methylpentanoyl-CoA = 4-methylpent-2-enoyl-CoA + H2O"}
{"X":48492,"RHEA_ID":46925,"DIRECTION":"LR","MASTER_ID":46924,"metacyc":"RXN-16247","compounds":"(R)-2-hydroxy-4-methylpentanoyl-CoA => 4-methylpent-2-enoyl-CoA + H2O"}
{"X":48493,"RHEA_ID":50312,"compounds":"2-oxopentanoate + H(+) = butanal + CO2"}
{"X":48494,"RHEA_ID":60375,"compounds":"D-fructose(out) <=> D-fructose(in)"}
{"X":48495,"RHEA_ID":46928,"DIRECTION":"UN","MASTER_ID":46928,"ec":"5.1.3.34","compounds":"a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol = a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol"}
{"X":48496,"RHEA_ID":46929,"DIRECTION":"LR","MASTER_ID":46928,"metacyc":"RXN-16647","compounds":"a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol"}
{"X":48497,"RHEA_ID":60378,"compounds":"D-glucose(in) => D-glucose(out)"}
{"X":48498,"RHEA_ID":46932,"DIRECTION":"UN","MASTER_ID":46932,"ec":"5.1.3.35","compounds":"2-epi-5-epi-valiolone 7-phosphate = 5-epi-valiolone 7-phosphate"}
{"X":48499,"RHEA_ID":46933,"compounds":"2-epi-5-epi-valiolone 7-phosphate => 5-epi-valiolone 7-phosphate"}
{"X":48500,"RHEA_ID":46934,"compounds":"5-epi-valiolone 7-phosphate => 2-epi-5-epi-valiolone 7-phosphate"}
{"X":48501,"RHEA_ID":56962,"compounds":"a ribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate => a ribonucleoside 5'-triphosphate + pyruvate"}
{"X":48502,"RHEA_ID":46936,"DIRECTION":"UN","MASTER_ID":46936,"ec":"1.2.1.95","compounds":"(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) = ATP + H(+) + L-2-aminoadipate + NADPH"}
{"X":48503,"RHEA_ID":56964,"compounds":"a 2'-deoxyribonucleoside 5'-triphosphate + pyruvate = a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate"}
{"X":48504,"RHEA_ID":46938,"DIRECTION":"RL","MASTER_ID":46936,"metacyc":"RXN-16756","compounds":"ATP + H(+) + L-2-aminoadipate + NADPH => (S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+)"}
{"X":48505,"RHEA_ID":56965,"compounds":"a 2'-deoxyribonucleoside 5'-triphosphate + pyruvate => a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate"}
{"X":48506,"RHEA_ID":46940,"compounds":"AMP + diphosphate + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] = ATP + holo-[LYS2 peptidyl-carrier protein] + L-2-aminoadipate"}
{"X":48507,"RHEA_ID":56968,"compounds":"dCTP + pyruvate = dCDP + H(+) + phosphoenolpyruvate"}
{"X":48508,"RHEA_ID":46942,"DIRECTION":"RL","MASTER_ID":46940,"metacyc":"RXN-16757","compounds":"ATP + holo-[LYS2 peptidyl-carrier protein] + L-2-aminoadipate => AMP + diphosphate + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein]"}
{"X":48509,"RHEA_ID":60391,"compounds":"Fe(III)-di(C-5-deoxy-beta-D-glucosyl)-enterobactin + H2O <=> Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+)"}
{"X":48510,"RHEA_ID":46944,"compounds":"(S)-2-amino-6-oxohexanoate + holo-[LYS2 peptidyl-carrier protein] + NADP(+) = H(+) + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] + NADPH"}
{"X":48511,"RHEA_ID":56972,"compounds":"(R)-3-hydroxy-2-methylpropanoate + NAD(+) = (R)-methylmalonate semialdehyde + H(+) + NADH"}
{"X":48512,"RHEA_ID":56973,"compounds":"(R)-3-hydroxy-2-methylpropanoate + NAD(+) => (R)-methylmalonate semialdehyde + H(+) + NADH"}
{"X":48513,"RHEA_ID":56974,"compounds":"(R)-methylmalonate semialdehyde + H(+) + NADH => (R)-3-hydroxy-2-methylpropanoate + NAD(+)"}
{"X":48514,"RHEA_ID":46948,"compounds":"GTP + S-adenosyl-L-methionine = 7-methyl-GTP + S-adenosyl-L-homocysteine"}
{"X":48515,"RHEA_ID":56976,"compounds":"4-methylphenol + H2O + 2 oxidized [azurin] = 4-hydroxybenzyl alcohol + 2 H(+) + 2 reduced [azurin]"}
{"X":48516,"RHEA_ID":46950,"compounds":"7-methyl-GTP + S-adenosyl-L-homocysteine => GTP + S-adenosyl-L-methionine"}
{"X":48517,"RHEA_ID":56978,"compounds":"4-hydroxybenzyl alcohol + 2 H(+) + 2 reduced [azurin] => 4-methylphenol + H2O + 2 oxidized [azurin]"}
{"X":48518,"RHEA_ID":46952,"DIRECTION":"UN","MASTER_ID":46952,"ec":"1.17.1.11","metacyc":"RXN-16835","compounds":"2 formate + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin] = 2 CO2 + H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":48519,"RHEA_ID":56980,"compounds":"4-hydroxybenzyl alcohol + 2 oxidized [azurin] = 4-hydroxybenzaldehyde + 2 H(+) + 2 reduced [azurin]"}
{"X":48520,"RHEA_ID":46954,"compounds":"2 CO2 + H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin] => 2 formate + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":48521,"RHEA_ID":56982,"compounds":"4-hydroxybenzaldehyde + 2 H(+) + 2 reduced [azurin] => 4-hydroxybenzyl alcohol + 2 oxidized [azurin]"}
{"X":48522,"RHEA_ID":46956,"DIRECTION":"UN","MASTER_ID":46956,"ec":"1.3.1.108","compounds":"hydrocaffeoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = (E)-caffeoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":48523,"RHEA_ID":56984,"compounds":"(2E,6E)-farnesyl diphosphate + H2O = (6E)-nerolidol + diphosphate"}
{"X":48524,"RHEA_ID":56985,"compounds":"(2E,6E)-farnesyl diphosphate + H2O => (6E)-nerolidol + diphosphate"}
{"X":48525,"RHEA_ID":56986,"compounds":"(6E)-nerolidol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}
{"X":48526,"RHEA_ID":46960,"DIRECTION":"UN","MASTER_ID":46960,"ec":"1.3.1.109","compounds":"butanoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = (2E)-butenoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":48527,"RHEA_ID":46961,"compounds":"butanoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] => (2E)-butenoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":48528,"RHEA_ID":56989,"DIRECTION":"LR","MASTER_ID":56988,"metacyc":"RXN-15458","compounds":"germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":48529,"RHEA_ID":46964,"DIRECTION":"UN","MASTER_ID":46964,"ec":"1.3.1.110","compounds":"lactate + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate"}
{"X":48530,"RHEA_ID":56992,"compounds":"6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) = (+)-costunolide + H2O"}
{"X":48531,"RHEA_ID":46966,"compounds":"2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate => lactate + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":48532,"RHEA_ID":56994,"compounds":"(+)-costunolide + H2O => 6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+)"}
{"X":48533,"RHEA_ID":46968,"DIRECTION":"UN","MASTER_ID":46968,"ec":"1.3.99.37","compounds":"A + dihydroisopentenyldehydrorhodopin = AH2 + isopentenyldehydrorhodopin"}
{"X":48534,"RHEA_ID":56996,"compounds":"aldehydo-D-apiose = apulose"}
{"X":48535,"RHEA_ID":56997,"compounds":"aldehydo-D-apiose => apulose"}
{"X":48536,"RHEA_ID":56998,"compounds":"apulose => aldehydo-D-apiose"}
{"X":48537,"RHEA_ID":46972,"DIRECTION":"UN","MASTER_ID":46972,"ec":"1.3.99.37","compounds":"A + dihydrobisanhydrobacterioruberin = AH2 + bisanhydrobacterioruberin"}
{"X":48538,"RHEA_ID":57000,"DIRECTION":"UN","MASTER_ID":57000,"metacyc":"RXN-11752","compounds":"acetyl-CoA + streptothricin F = CoA + H(+) + N(beta)-acetylstreptothricin F"}
{"X":48539,"RHEA_ID":57001,"compounds":"acetyl-CoA + streptothricin F => CoA + H(+) + N(beta)-acetylstreptothricin F"}
{"X":48540,"RHEA_ID":46975,"DIRECTION":"BI","MASTER_ID":46972,"metacyc":"RXN-16704","compounds":"A + dihydrobisanhydrobacterioruberin <=> AH2 + bisanhydrobacterioruberin"}
{"X":48541,"RHEA_ID":46976,"compounds":"(S)-6-hydroxynicotine + O2 = 6-hydroxy-N-methylmyosmine + H2O2"}
{"X":48542,"RHEA_ID":57004,"compounds":"acetyl-CoA + streptothricin D = CoA + H(+) + N(beta)-acetylstreptothricin D"}
{"X":48543,"RHEA_ID":57005,"compounds":"acetyl-CoA + streptothricin D => CoA + H(+) + N(beta)-acetylstreptothricin D"}
{"X":48544,"RHEA_ID":57006,"compounds":"CoA + H(+) + N(beta)-acetylstreptothricin D => acetyl-CoA + streptothricin D"}
{"X":48545,"RHEA_ID":46988,"compounds":"(R)-6-hydroxynicotine + O2 = 6-hydroxy-N-methylmyosmine + H2O2"}
{"X":48546,"RHEA_ID":57008,"compounds":"5,5'-dehydrodivanillate + H(+) + NADH + O2 = 2,2',3-trihydroxy-3'-methoxy-5,5'-dicarboxybiphenyl + formaldehyde + H2O + NAD(+)"}
{"X":48547,"RHEA_ID":57009,"DIRECTION":"LR","MASTER_ID":57008,"metacyc":"RXN-10894","compounds":"5,5'-dehydrodivanillate + H(+) + NADH + O2 => 2,2',3-trihydroxy-3'-methoxy-5,5'-dicarboxybiphenyl + formaldehyde + H2O + NAD(+)"}
{"X":48548,"RHEA_ID":60447,"compounds":"an S-substitued L-cysteinylglycine + H2O <=> an S-substituted L-cysteine + glycine"}
{"X":48549,"RHEA_ID":46996,"compounds":"6-hydroxy-N-methylmyosmine + H2O = 6-hydroxypseudooxynicotine"}
{"X":48550,"RHEA_ID":57012,"compounds":"a menaquinone + H2O + sulfite = a menaquinol + sulfate"}
{"X":48551,"RHEA_ID":57013,"DIRECTION":"LR","MASTER_ID":57012,"metacyc":"RXN-15349","compounds":"a menaquinone + H2O + sulfite => a menaquinol + sulfate"}
{"X":48552,"RHEA_ID":60459,"compounds":"ATP + UTP <=> 3',3'-cUAMP + 2 diphosphate"}
{"X":48553,"RHEA_ID":47000,"DIRECTION":"UN","MASTER_ID":47000,"ec":"1.6.1.4","compounds":"H(+) + NADH + 2 NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NAD(+) + 2 NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":48554,"RHEA_ID":47001,"compounds":"H(+) + NADH + 2 NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] => NAD(+) + 2 NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":48555,"RHEA_ID":57017,"compounds":"3,6-dichloro-2-methoxybenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3,6-dichlorosalicylate + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":48556,"RHEA_ID":47003,"DIRECTION":"BI","MASTER_ID":47000,"metacyc":"RXN-16837","compounds":"H(+) + NADH + 2 NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> NAD(+) + 2 NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":48557,"RHEA_ID":47004,"DIRECTION":"UN","MASTER_ID":47004,"ec":"3.1.3.16","compounds":"H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate"}
{"X":48558,"RHEA_ID":57020,"compounds":"apulose + ATP = ADP + apulose 4-phosphate + H(+)"}
{"X":48559,"RHEA_ID":57021,"compounds":"apulose + ATP => ADP + apulose 4-phosphate + H(+)"}
{"X":48560,"RHEA_ID":57022,"compounds":"ADP + apulose 4-phosphate + H(+) => apulose + ATP"}
{"X":48561,"RHEA_ID":47008,"DIRECTION":"UN","MASTER_ID":47008,"ec":"1.8.99.5","compounds":"[DsrC protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide = [DsrC protein]-dithiol + 2 AH2 + H(+) + sulfite"}
{"X":48562,"RHEA_ID":57024,"compounds":"apulose 4-phosphate + D-glyceraldehyde 3-phosphate = D-xylulose 5-phosphate + dihydroxyacetone phosphate"}
{"X":48563,"RHEA_ID":47010,"compounds":"[DsrC protein]-dithiol + 2 AH2 + H(+) + sulfite => [DsrC protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide"}
{"X":48564,"RHEA_ID":47011,"DIRECTION":"BI","MASTER_ID":47008,"metacyc":"SULFITE-REDUCTASE-RXN","compounds":"[DsrC protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide <=> [DsrC protein]-dithiol + 2 AH2 + H(+) + sulfite"}
{"X":48565,"RHEA_ID":47012,"compounds":"[DsrC protein]-disulfide + H(+) + hydrogen sulfide = [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine"}
{"X":48566,"RHEA_ID":57027,"compounds":"apulose 4-phosphate + D-glyceraldehyde 3-phosphate <=> D-xylulose 5-phosphate + dihydroxyacetone phosphate"}
{"X":48567,"RHEA_ID":47014,"compounds":"[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine => [DsrC protein]-disulfide + H(+) + hydrogen sulfide"}
{"X":48568,"RHEA_ID":57030,"compounds":"(Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FAD + H(+) => FADH2 + N-methylnicotinate + O2"}
{"X":48569,"RHEA_ID":47016,"compounds":"[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 2 A + 3 H2O = [DsrC protein]-dithiol + 2 AH2 + 2 H(+) + sulfite"}
{"X":48570,"RHEA_ID":57032,"compounds":"(E)-2-((N-methylformamido) methylene)succinate + H(+) + 2 H2O = CO2 + formate + methylamine + succinate semialdehyde"}
{"X":48571,"RHEA_ID":47018,"DIRECTION":"RL","MASTER_ID":47016,"metacyc":"RXN-11922","compounds":"[DsrC protein]-dithiol + 2 AH2 + 2 H(+) + sulfite => [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 2 A + 3 H2O"}
{"X":48572,"RHEA_ID":47019,"compounds":"[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 2 A + 3 H2O <=> [DsrC protein]-dithiol + 2 AH2 + 2 H(+) + sulfite"}
{"X":48573,"RHEA_ID":47020,"DIRECTION":"UN","MASTER_ID":47020,"ec":"1.8.99.5","compounds":"[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O = [DsrC protein]-disulfide + 3 AH2 + 2 H(+) + sulfite"}
{"X":48574,"RHEA_ID":53701,"compounds":"2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine"}
{"X":48575,"RHEA_ID":47022,"compounds":"[DsrC protein]-disulfide + 3 AH2 + 2 H(+) + sulfite => [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O"}
{"X":48576,"RHEA_ID":57038,"compounds":"(1->3)-alpha-D-glucosyl-[(1->6)-alpha-D-glucosyl]n + D-fructose => [(1->6)-alpha-D-glucosyl](n) + sucrose"}
{"X":48577,"RHEA_ID":47024,"compounds":"[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O = [DsrC protein]-S-sulfo-L-cysteine/L-cysteine + 3 AH2 + H(+)"}
{"X":48578,"RHEA_ID":57040,"compounds":"aldehydo-D-apiose = D-apiofuranose"}
{"X":48579,"RHEA_ID":57041,"compounds":"aldehydo-D-apiose => D-apiofuranose"}
{"X":48580,"RHEA_ID":57042,"compounds":"D-apiofuranose => aldehydo-D-apiose"}
{"X":48581,"RHEA_ID":47028,"compounds":"[DsrC protein]-S-sulfo-L-cysteine/L-cysteine = [DsrC protein]-disulfide + H(+) + sulfite"}
{"X":48582,"RHEA_ID":57044,"DIRECTION":"UN","MASTER_ID":57044,"ec":"1.1.1.421","compounds":"D-apionate + NAD(+) = 3-oxo-D-isoapionate + H(+) + NADH"}
{"X":48583,"RHEA_ID":47030,"compounds":"[DsrC protein]-disulfide + H(+) + sulfite => [DsrC protein]-S-sulfo-L-cysteine/L-cysteine"}
{"X":48584,"RHEA_ID":47031,"compounds":"[DsrC protein]-S-sulfo-L-cysteine/L-cysteine <=> [DsrC protein]-disulfide + H(+) + sulfite"}
{"X":48585,"RHEA_ID":47032,"DIRECTION":"UN","MASTER_ID":47032,"ec":"2.8.1.13","compounds":"AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA = 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]"}
{"X":48586,"RHEA_ID":53713,"DIRECTION":"LR","MASTER_ID":53712,"metacyc":"RXN-10785","compounds":"2 Fe(III)-heme b => beta-hematin"}
{"X":48587,"RHEA_ID":47034,"compounds":"2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein] => AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA"}
{"X":48588,"RHEA_ID":57050,"compounds":"2-thiocytidine(32) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[cysteine desulfurase] => AH2 + ATP + cytidine(32) in tRNA + S-sulfanyl-L-cysteinyl-[cysteine desulfurase]"}
{"X":48589,"RHEA_ID":47036,"compounds":"uridine in 5S rRNA = pseudouridine in 5S rRNA"}
{"X":48590,"RHEA_ID":53717,"DIRECTION":"LR","MASTER_ID":53716,"metacyc":"RXN-18661","compounds":"H(+) + N-acetyl-alpha-D-muramate 1-phosphate + UDP => phosphate + UDP-N-acetyl-alpha-D-muramate"}
{"X":48591,"RHEA_ID":57053,"compounds":"3-oxo-isoapionate + H(+) => CO2 + L-erythrulose"}
{"X":48592,"RHEA_ID":60515,"compounds":"a guanosine in miRNA + S-adenosyl-L-methionine <=> an N(7)-methylguanosine in miRNA + S-adenosyl-L-homocysteine"}
{"X":48593,"RHEA_ID":47040,"DIRECTION":"UN","MASTER_ID":47040,"ec":"2.8.1.14","compounds":"5-taurinomethyluridine(34) in tRNA + AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] = 5-taurinomethyl-2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]"}
{"X":48594,"RHEA_ID":47041,"compounds":"5-taurinomethyluridine(34) in tRNA + AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] => 5-taurinomethyl-2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]"}
{"X":48595,"RHEA_ID":50416,"DIRECTION":"UN","MASTER_ID":50416,"ec":"2.3.2.6","compounds":"L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] = H(+) + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu)"}
{"X":48596,"RHEA_ID":60519,"compounds":"L-tryptophan <=> D-tryptophan"}
{"X":48597,"RHEA_ID":47044,"compounds":"3-dehydrocarnitine + acetyl-CoA = acetoacetate + N,N,N-trimethylglycyl-CoA"}
{"X":48598,"RHEA_ID":57060,"DIRECTION":"UN","MASTER_ID":57060,"ec":"3.1.1.106","compounds":"2''-O-acetyl-ADP-D-ribose + H2O = acetate + ADP-D-ribose + H(+)"}
{"X":48599,"RHEA_ID":47046,"compounds":"acetoacetate + N,N,N-trimethylglycyl-CoA => 3-dehydrocarnitine + acetyl-CoA"}
{"X":48600,"RHEA_ID":47047,"compounds":"3-dehydrocarnitine + acetyl-CoA <=> acetoacetate + N,N,N-trimethylglycyl-CoA"}
{"X":48601,"RHEA_ID":47048,"compounds":"a quinone + shikimate = 3-dehydroshikimate + a quinol"}
{"X":48602,"RHEA_ID":57064,"compounds":"D-apionolactone + H2O = D-apionate + H(+)"}
{"X":48603,"RHEA_ID":47050,"compounds":"3-dehydroshikimate + a quinol => a quinone + shikimate"}
{"X":48604,"RHEA_ID":60527,"compounds":"5-hydroxyuridine(34) in tRNA + S-adenosyl-L-methionine <=> 5-methoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":48605,"RHEA_ID":47052,"DIRECTION":"UN","MASTER_ID":47052,"ec":"4.2.3.198","compounds":"(2E,6E)-farnesyl diphosphate = alpha-selinene + diphosphate"}
{"X":48606,"RHEA_ID":57068,"compounds":"3-oxo-isoapionate + ATP = 3-oxo-isoapionate 4-phosphate + ADP + H(+)"}
{"X":48607,"RHEA_ID":47054,"compounds":"alpha-selinene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":48608,"RHEA_ID":60559,"compounds":"uridine(35) in tRNA(Tyr) <=> pseudouridine(35) in tRNA(Tyr)"}
{"X":48609,"RHEA_ID":47056,"compounds":"4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}
{"X":48610,"RHEA_ID":57072,"compounds":"3-oxo-isoapionate 4-phosphate + H(+) = CO2 + L-erythrulose 1-phosphate"}
{"X":48611,"RHEA_ID":50432,"compounds":"AH2 + prostaglandin G1 = A + H2O + prostaglandin H1"}
{"X":48612,"RHEA_ID":60563,"compounds":"L-methionyl-[protein] + S-adenosyl-L-methionine <=> S-adenosyl-L-homocysteine + S-methyl-L-methionyl-[protein]"}
{"X":48613,"RHEA_ID":47060,"compounds":"4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":48614,"RHEA_ID":47061,"compounds":"4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":48615,"RHEA_ID":47062,"compounds":"4alpha-hydroxymethyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O => 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}
{"X":48616,"RHEA_ID":60567,"compounds":"2-deoxy-D-glucose + ATP <=> 2-deoxy-D-glucose 6-phosphate + ADP + H(+)"}
{"X":48617,"RHEA_ID":47064,"compounds":"4alpha-hydroxymethyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 4alpha-formyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":48618,"RHEA_ID":47065,"compounds":"4alpha-hydroxymethyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 4alpha-formyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":48619,"RHEA_ID":47066,"compounds":"4alpha-formyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}
{"X":48620,"RHEA_ID":50441,"compounds":"prostaglandin H1 => prostaglandin D1"}
{"X":48621,"RHEA_ID":47068,"compounds":"4alpha-formyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 = 4alpha-carboxyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":48622,"RHEA_ID":57084,"compounds":"a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O = a fatty acid + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+)"}
{"X":48623,"RHEA_ID":47070,"compounds":"4alpha-carboxyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O => 4alpha-formyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2"}
{"X":48624,"RHEA_ID":50445,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 O2 => prostaglandin G3"}
{"X":48625,"RHEA_ID":47072,"compounds":"1-eicosanoylglycerol + H2O = eicosanoate + glycerol + H(+)"}
{"X":48626,"RHEA_ID":57088,"compounds":"an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O = 3-beta-D-galactosyl-sn-glycerol + a fatty acid + H(+)"}
{"X":48627,"RHEA_ID":47074,"compounds":"eicosanoate + glycerol + H(+) => 1-eicosanoylglycerol + H2O"}
{"X":48628,"RHEA_ID":50449,"compounds":"AH2 + prostaglandin G3 => A + H2O + prostaglandin H3"}
{"X":48629,"RHEA_ID":47076,"compounds":"17beta-hydroxyandrosta-1,4-dien-3-one + H(+) + NADPH = 17beta-hydroxy-5beta-androst-1-en-3-one + NADP(+)"}
{"X":48630,"RHEA_ID":57092,"compounds":"AH2 + S-(methylsulfanyl)glutathione = A + glutathione + methanethiol"}
{"X":48631,"RHEA_ID":47078,"compounds":"17beta-hydroxy-5beta-androst-1-en-3-one + NADP(+) => 17beta-hydroxyandrosta-1,4-dien-3-one + H(+) + NADPH"}
{"X":48632,"RHEA_ID":47079,"compounds":"17beta-hydroxyandrosta-1,4-dien-3-one + H(+) + NADPH <=> 17beta-hydroxy-5beta-androst-1-en-3-one + NADP(+)"}
{"X":48633,"RHEA_ID":47080,"compounds":"17beta-hydroxyestr-4-en-3-one + H(+) + NADPH = 17beta-hydroxy-5beta-estran-3-one + NADP(+)"}
{"X":48634,"RHEA_ID":57096,"compounds":"1-methylsulfanyl-D-xylulose 5-phosphate + AH2 = 1-deoxy-D-xylulose 5-phosphate + A + methanethiol"}
{"X":48635,"RHEA_ID":57097,"DIRECTION":"LR","MASTER_ID":57096,"metacyc":"RXN-14007","compounds":"1-methylsulfanyl-D-xylulose 5-phosphate + AH2 => 1-deoxy-D-xylulose 5-phosphate + A + methanethiol"}
{"X":48636,"RHEA_ID":53763,"compounds":"allocholate + deoxycholoyl-CoA <=> allocholoyl-CoA + deoxycholate"}
{"X":48637,"RHEA_ID":47084,"compounds":"4-methylsulfanyl-2-oxobutanoate + L-tyrosine = 3-(4-hydroxyphenyl)pyruvate + L-methionine"}
{"X":48638,"RHEA_ID":57100,"compounds":"5-methylsulfanyl-D-ribulose 1-phosphate = 1-methylsulfanyl-D-xylulose 5-phosphate"}
{"X":48639,"RHEA_ID":50460,"DIRECTION":"UN","MASTER_ID":50460,"ec":"6.2.1.47","compounds":"a medium chain fatty acid + ATP + holo-[ACP] = a medium-chain fatty acyl-[ACP] + AMP + diphosphate"}
{"X":48640,"RHEA_ID":60615,"compounds":"1-octanoyl-sn-glycero-3-phosphocholine <=> 1-octanoyl-sn-glycero-2,3-cyclic phosphate + choline"}
{"X":48641,"RHEA_ID":47088,"compounds":"(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + NAD(+) = 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH"}
{"X":48642,"RHEA_ID":57104,"DIRECTION":"UN","MASTER_ID":57104,"ec":"4.2.2.9","compounds":"[(1->4)-alpha-D-galacturonosyl](n) = 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate + [(1->4)-alpha-D-galacturonosyl](n-2)"}
{"X":48643,"RHEA_ID":57105,"DIRECTION":"LR","MASTER_ID":57104,"metacyc":"4.2.2.9-RXN","compounds":"[(1->4)-alpha-D-galacturonosyl](n) => 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate + [(1->4)-alpha-D-galacturonosyl](n-2)"}
{"X":48644,"RHEA_ID":60619,"compounds":"N-dodecanoyl-heptadecasphing-4-enine-1-phosphoethanolamine <=> ethanolamine + N-dodecanoyl-heptadecasphing-4-enine-1,3-cyclic phosphate"}
{"X":48645,"RHEA_ID":47092,"compounds":"(S)-2,3-dihydrodipicolinate + NADP(+) = dipicolinate + H(+) + NADPH"}
{"X":48646,"RHEA_ID":47093,"compounds":"(S)-2,3-dihydrodipicolinate + NADP(+) => dipicolinate + H(+) + NADPH"}
{"X":48647,"RHEA_ID":50468,"DIRECTION":"UN","MASTER_ID":50468,"ec":"2.3.1.261","compounds":"4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 27 H(+) + 9 malonyl-CoA + 18 NADPH = 19-(4-hydroxyphenyl)nonadecanoyl-[4-hydroxyphenylalkanoate synthase] + 9 CO2 + 9 CoA + 9 H2O + 18 NADP(+)"}
{"X":48648,"RHEA_ID":60623,"compounds":"N-hexanoyl-sphing-4-enine-1-phosphocholine <=> choline + N-(hexanoyl)-sphing-4-enine-1,3-cyclic phosphate"}
{"X":48649,"RHEA_ID":47096,"DIRECTION":"UN","MASTER_ID":47096,"ec":"2.5.1.86","compounds":"(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate = (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate + 7 diphosphate"}
{"X":48650,"RHEA_ID":47097,"DIRECTION":"LR","MASTER_ID":47096,"metacyc":"RXN-11023","compounds":"(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate => (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate + 7 diphosphate"}
{"X":48651,"RHEA_ID":57112,"compounds":"1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine"}
{"X":48652,"RHEA_ID":57113,"compounds":"1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine"}
{"X":48653,"RHEA_ID":47100,"compounds":"choloyl-CoA + taurine = CoA + H(+) + taurocholate"}
{"X":48654,"RHEA_ID":57115,"compounds":"1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine"}
{"X":48655,"RHEA_ID":47102,"compounds":"CoA + H(+) + taurocholate => choloyl-CoA + taurine"}
{"X":48656,"RHEA_ID":50477,"DIRECTION":"LR","MASTER_ID":50476,"metacyc":"RXN-17709","compounds":"anthraniloyl-CoA + L-cysteinyl-[PqsD protein] => CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein]"}
{"X":48657,"RHEA_ID":47104,"compounds":"5,10-methylenetetrahydromethanopterin + glycine + H2O = 5,6,7,8-tetrahydromethanopterin + L-serine"}
{"X":48658,"RHEA_ID":47105,"compounds":"5,10-methylenetetrahydromethanopterin + glycine + H2O => 5,6,7,8-tetrahydromethanopterin + L-serine"}
{"X":48659,"RHEA_ID":57120,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine"}
{"X":48660,"RHEA_ID":47107,"compounds":"5,10-methylenetetrahydromethanopterin + glycine + H2O <=> 5,6,7,8-tetrahydromethanopterin + L-serine"}
{"X":48661,"RHEA_ID":47108,"compounds":"cholate + taurine = H2O + taurocholate"}
{"X":48662,"RHEA_ID":47109,"compounds":"cholate + taurine => H2O + taurocholate"}
{"X":48663,"RHEA_ID":57124,"compounds":"2-oxoglutaramate = 2-hydroxy-5-oxoproline"}
{"X":48664,"RHEA_ID":50485,"DIRECTION":"LR","MASTER_ID":50484,"metacyc":"RXN-17850","compounds":"acetyl-CoA + N-terminal L-methionyl-L-asparaginyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-asparaginyl-[protein]"}
{"X":48665,"RHEA_ID":47112,"compounds":"chenodeoxycholate + glycine = glycochenodeoxycholate + H2O"}
{"X":48666,"RHEA_ID":47113,"compounds":"chenodeoxycholate + glycine => glycochenodeoxycholate + H2O"}
{"X":48667,"RHEA_ID":53794,"compounds":"benzothialdehyde + H2O2 => O2 + phenylmethanethiol"}
{"X":48668,"RHEA_ID":60647,"compounds":"3'-phosphoadenylyl sulfate + 3alpha-hydroxy-5alpha-androstan-17-one <=> 3alpha-sulfooxy-5alpha-androstan-17-one + adenosine 3',5'-bisphosphate + H(+)"}
{"X":48669,"RHEA_ID":47116,"compounds":"eicosanoate + glycine = H2O + N-eicosanoylglycinate"}
{"X":48670,"RHEA_ID":47117,"compounds":"eicosanoate + glycine => H2O + N-eicosanoylglycinate"}
{"X":48671,"RHEA_ID":50492,"DIRECTION":"UN","MASTER_ID":50492,"ec":"2.3.1.254","compounds":"acetyl-CoA + N-terminal L-methionyl-L-glutaminyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutaminyl-[protein]"}
{"X":48672,"RHEA_ID":53799,"compounds":"deoxycholoyl-CoA + ursodeoxycholate <=> deoxycholate + ursodeoxycholoyl-CoA"}
{"X":48673,"RHEA_ID":47120,"compounds":"docosanoate + glycine = H2O + N-docosanoylglycine"}
{"X":48674,"RHEA_ID":47121,"compounds":"docosanoate + glycine => H2O + N-docosanoylglycine"}
{"X":48675,"RHEA_ID":50496,"DIRECTION":"UN","MASTER_ID":50496,"ec":"2.3.1.255","compounds":"acetyl-CoA + N-terminal glycyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetylglycyl-[protein]"}
{"X":48676,"RHEA_ID":60655,"compounds":"an N-(acyl)-sphingosylphosphocholine <=> an N-(acyl)-sphingosyl-1,3-cyclic phosphate + choline"}
{"X":48677,"RHEA_ID":47124,"compounds":"glycine + hexacosanoate = H2O + N-hexacosanoylglycine"}
{"X":48678,"RHEA_ID":47125,"compounds":"glycine + hexacosanoate => H2O + N-hexacosanoylglycine"}
{"X":48679,"RHEA_ID":57140,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine"}
{"X":48680,"RHEA_ID":60659,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-sn-glycero-2,3-cyclic phosphate + choline"}
{"X":48681,"RHEA_ID":47128,"compounds":"ATP + CoA + deoxycholate = AMP + deoxycholoyl-CoA + diphosphate"}
{"X":48682,"RHEA_ID":47129,"compounds":"ATP + CoA + deoxycholate => AMP + deoxycholoyl-CoA + diphosphate"}
{"X":48683,"RHEA_ID":53810,"compounds":"(24S)-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholestanol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":48684,"RHEA_ID":60663,"compounds":"1,4-benzoquinone + H(+) + NADH <=> hydroquinone + NAD(+)"}
{"X":48685,"RHEA_ID":47132,"compounds":"11-cis-retinal + H2O + NAD(+) = 11-cis-retinoate + 2 H(+) + NADH"}
{"X":48686,"RHEA_ID":47133,"compounds":"11-cis-retinal + H2O + NAD(+) => 11-cis-retinoate + 2 H(+) + NADH"}
{"X":48687,"RHEA_ID":57148,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)"}
{"X":48688,"RHEA_ID":53815,"compounds":"cholestanol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-26-hydroxycholestanol + H2O + 2 oxidized [adrenodoxin]"}
{"X":48689,"RHEA_ID":47136,"compounds":"ATP + CoA + lithocholate = AMP + diphosphate + lithocholoyl-CoA"}
{"X":48690,"RHEA_ID":47137,"compounds":"ATP + CoA + lithocholate => AMP + diphosphate + lithocholoyl-CoA"}
{"X":48691,"RHEA_ID":60670,"compounds":"(1R,3R)-chrysanthemal + H(+) + NADH => (R,R)-chrysanthemol + NAD(+)"}
{"X":48692,"RHEA_ID":53819,"compounds":"hydrogen sulfide + O-succinyl-L-serine <=> L-cysteine + succinate"}
{"X":48693,"RHEA_ID":47140,"DIRECTION":"UN","MASTER_ID":47140,"ec":"1.14.19.3","compounds":"(9Z,12Z)-octadecadienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":48694,"RHEA_ID":47141,"DIRECTION":"LR","MASTER_ID":47140,"metacyc":"1.14.19.3-RXN","compounds":"(9Z,12Z)-octadecadienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":48695,"RHEA_ID":60674,"compounds":"H(+) + NADH + neral => NAD(+) + nerol"}
{"X":48696,"RHEA_ID":60675,"DIRECTION":"BI","MASTER_ID":60672,"metacyc":"RXN-11969","compounds":"NAD(+) + nerol <=> H(+) + NADH + neral"}
{"X":48697,"RHEA_ID":47144,"DIRECTION":"UN","MASTER_ID":47144,"ec":"1.14.19.3","compounds":"(9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":48698,"RHEA_ID":47145,"DIRECTION":"LR","MASTER_ID":47144,"metacyc":"RXN-13426","compounds":"(9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":48699,"RHEA_ID":57160,"compounds":"2-oxoglutarate + L-arginyl-[ribosomal protein eS6] + O2 = (3R)-3-hydroxy-L-arginyl-[ribosomal protein eS6] + CO2 + succinate"}
{"X":48700,"RHEA_ID":53827,"compounds":"NAD(+) + taurochenodeoxycholate <=> 7-oxo-taurolithocholate + H(+) + NADH"}
{"X":48701,"RHEA_ID":47148,"DIRECTION":"UN","MASTER_ID":47148,"ec":"1.17.5.2","compounds":"a ubiquinone + caffeine + H2O = 1,3,7-trimethylurate + a ubiquinol"}
{"X":48702,"RHEA_ID":47149,"DIRECTION":"LR","MASTER_ID":47148,"metacyc":"RXN-11523","compounds":"a ubiquinone + caffeine + H2O => 1,3,7-trimethylurate + a ubiquinol"}
{"X":48703,"RHEA_ID":53830,"compounds":"a 5-formyl-2'-deoxycytidine in DNA + CO2 + H2O + succinate => 2-oxoglutarate + a 5-hydroxymethyl-2'-deoxycytidine in DNA + O2"}
{"X":48704,"RHEA_ID":53831,"compounds":"2-oxoglutarate + a 5-hydroxymethyl-2'-deoxycytidine in DNA + O2 <=> a 5-formyl-2'-deoxycytidine in DNA + CO2 + H2O + succinate"}
{"X":48705,"RHEA_ID":47152,"compounds":"2,5-dioxopentanoate + H2O + NAD(+) = 2-oxoglutarate + 2 H(+) + NADH"}
{"X":48706,"RHEA_ID":47153,"DIRECTION":"LR","MASTER_ID":47152,"metacyc":"RXN-8775","compounds":"2,5-dioxopentanoate + H2O + NAD(+) => 2-oxoglutarate + 2 H(+) + NADH"}
{"X":48707,"RHEA_ID":53834,"compounds":"a 5-carboxyl-2'-deoxycytidine in DNA + CO2 + H(+) + succinate => 2-oxoglutarate + a 5-formyl-2'-deoxycytidine in DNA + O2"}
{"X":48708,"RHEA_ID":53835,"compounds":"2-oxoglutarate + a 5-formyl-2'-deoxycytidine in DNA + O2 <=> a 5-carboxyl-2'-deoxycytidine in DNA + CO2 + H(+) + succinate"}
{"X":48709,"RHEA_ID":47156,"compounds":"7alpha,25-dihydroxycholesterol + NAD(+) = 7alpha,25-dihydroxy-4-cholesten-3-one + H(+) + NADH"}
{"X":48710,"RHEA_ID":47157,"compounds":"7alpha,25-dihydroxycholesterol + NAD(+) => 7alpha,25-dihydroxy-4-cholesten-3-one + H(+) + NADH"}
{"X":48711,"RHEA_ID":53838,"compounds":"a UDP-2-N,3-O-bis((3R)-3-hydroxyacyl)-alpha-D-glucosamine + H(+) + holo-[ACP] => a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-acyl-alpha-D-glucosamine"}
{"X":48712,"RHEA_ID":60691,"compounds":"(11R)-dihydroartemisinic aldehyde + H2O + NAD(+) <=> (11R)-dihydroartemisinate + 2 H(+) + NADH"}
{"X":48713,"RHEA_ID":47160,"compounds":"4alpha-carboxyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+) = 4-methyl-5alpha-cholesta-8,24-dien-3-one + CO2 + NADH"}
{"X":48714,"RHEA_ID":47161,"compounds":"4alpha-carboxyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+) => 4-methyl-5alpha-cholesta-8,24-dien-3-one + CO2 + NADH"}
{"X":48715,"RHEA_ID":60694,"compounds":"(E)-non-2-enoate + 2 H(+) + NADPH => (E)-non-2-enal + H2O + NADP(+)"}
{"X":48716,"RHEA_ID":53847,"compounds":"glycochenodeoxycholate + NAD(+) <=> 7-oxo-glycolithocholate + H(+) + NADH"}
{"X":48717,"RHEA_ID":47164,"compounds":"4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+) = CO2 + NADH + zymosterone"}
{"X":48718,"RHEA_ID":47165,"compounds":"4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+) => CO2 + NADH + zymosterone"}
{"X":48719,"RHEA_ID":60698,"compounds":"(R)-lavandulol + diphosphate => (R)-lavandulyl diphosphate + H2O"}
{"X":48720,"RHEA_ID":60699,"compounds":"(R)-lavandulyl diphosphate + H2O <=> (R)-lavandulol + diphosphate"}
{"X":48721,"RHEA_ID":47168,"compounds":"4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NAD(+) = 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADH"}
{"X":48722,"RHEA_ID":47169,"compounds":"4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NAD(+) => 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADH"}
{"X":48723,"RHEA_ID":47170,"compounds":"4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADH => 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NAD(+)"}
{"X":48724,"RHEA_ID":60703,"compounds":"a 1-acyl-sn-glycero-3-phosphocholine <=> a 1-acyl-sn-glycero-2,3-cyclic phosphate + choline"}
{"X":48725,"RHEA_ID":47172,"compounds":"4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NAD(+) = 5alpha-cholest-8-en-3-one + CO2 + NADH"}
{"X":48726,"RHEA_ID":47173,"compounds":"4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NAD(+) => 5alpha-cholest-8-en-3-one + CO2 + NADH"}
{"X":48727,"RHEA_ID":50545,"DIRECTION":"LR","MASTER_ID":50544,"reactome":"R-HSA-2161735.2","compounds":"prostaglandin C2 => prostaglandin B2"}
{"X":48728,"RHEA_ID":47175,"compounds":"4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NAD(+) <=> 5alpha-cholest-8-en-3-one + CO2 + NADH"}
{"X":48729,"RHEA_ID":47176,"compounds":"(2R)-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O"}
{"X":48730,"RHEA_ID":47177,"compounds":"(2R)-hydroxybutanoyl-CoA => (2E)-butenoyl-CoA + H2O"}
{"X":48731,"RHEA_ID":53862,"compounds":"dehydrocholate + H(+) + NADPH => 7beta-hydroxy-3,12-dioxo-5beta-cholan-24-oate + NADP(+)"}
{"X":48732,"RHEA_ID":53863,"compounds":"7beta-hydroxy-3,12-dioxo-5beta-cholan-24-oate + NADP(+) <=> dehydrocholate + H(+) + NADPH"}
{"X":48733,"RHEA_ID":47180,"compounds":"(25R)-cholest-5-en-3beta,7alpha,26-triol + NAD(+) = (25R)-7alpha,26-dihydroxycholest-4-en-3-one + H(+) + NADH"}
{"X":48734,"RHEA_ID":47181,"compounds":"(25R)-cholest-5-en-3beta,7alpha,26-triol + NAD(+) => (25R)-7alpha,26-dihydroxycholest-4-en-3-one + H(+) + NADH"}
{"X":48735,"RHEA_ID":50553,"compounds":"prostaglandin C1 => prostaglandin B1"}
{"X":48736,"RHEA_ID":60715,"compounds":"(+)-artemisinic alcohol + NAD(+) <=> (+)-artemisinic aldehyde + H(+) + NADH"}
{"X":48737,"RHEA_ID":47184,"compounds":"5alpha-cholesta-7,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + cholesta-5,7,24-trien-3beta-ol + 2 H2O"}
{"X":48738,"RHEA_ID":47185,"compounds":"5alpha-cholesta-7,24-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + cholesta-5,7,24-trien-3beta-ol + 2 H2O"}
{"X":48739,"RHEA_ID":50557,"DIRECTION":"LR","MASTER_ID":50556,"reactome":"R-HSA-2161733.2","compounds":"prostaglandin D2 => H2O + prostaglandin J2"}
{"X":48740,"RHEA_ID":60718,"compounds":"(1R,3R)-chrysanthemate + 2 H(+) + NADPH => (1R,3R)-chrysanthemal + H2O + NADP(+)"}
{"X":48741,"RHEA_ID":47188,"compounds":"[Co(I) methylated-thiol-specific corrinoid protein] + methanethiol = [methyl-Co(III) methylated-thiol-specific corrinoid protein] + hydrogen sulfide"}
{"X":48742,"RHEA_ID":47189,"DIRECTION":"LR","MASTER_ID":47188,"metacyc":"RXN-8128","compounds":"[Co(I) methylated-thiol-specific corrinoid protein] + methanethiol => [methyl-Co(III) methylated-thiol-specific corrinoid protein] + hydrogen sulfide"}
{"X":48743,"RHEA_ID":57204,"compounds":"glyoxal + L-lysyl-[protein] = N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein]"}
{"X":48744,"RHEA_ID":53875,"compounds":"CTP + D-ribose 5-phosphate + H(+) <=> CDP-D-ribose + diphosphate"}
{"X":48745,"RHEA_ID":47192,"compounds":"[methyl-Co(III) methylated-thiol-specific corrinoid protein] + coenzyme M = [Co(I) methylated-thiol-specific corrinoid protein] + H(+) + methyl-coenzyme M"}
{"X":48746,"RHEA_ID":47193,"DIRECTION":"LR","MASTER_ID":47192,"metacyc":"RXN-8126","compounds":"[methyl-Co(III) methylated-thiol-specific corrinoid protein] + coenzyme M => [Co(I) methylated-thiol-specific corrinoid protein] + H(+) + methyl-coenzyme M"}
{"X":48747,"RHEA_ID":50565,"DIRECTION":"LR","MASTER_ID":50564,"metacyc":"RXN-17869","compounds":"acetyl-CoA + N-terminal L-methionyl-L-alanyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-alanyl-[protein]"}
{"X":48748,"RHEA_ID":53879,"compounds":"a cytidine in tRNA + acetyl-CoA + ATP + H2O <=> ADP + an N(4)-acetylcytidine in tRNA + CoA + H(+) + phosphate"}
{"X":48749,"RHEA_ID":47196,"DIRECTION":"UN","MASTER_ID":47196,"ec":"1.3.8.1","compounds":"a short-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":48750,"RHEA_ID":47197,"DIRECTION":"LR","MASTER_ID":47196,"metacyc":"RXN-13449","compounds":"a short-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":48751,"RHEA_ID":57212,"compounds":"dGTP + methylglyoxal = N(2)-(1-hydroxy-2-oxopropyl)-dGTP"}
{"X":48752,"RHEA_ID":48302,"compounds":"glycerol + H(+) + prostaglandin F2alpha => H2O + prostaglandin F2alpha 1-glyceryl ester"}
{"X":48753,"RHEA_ID":47200,"compounds":"(24S)-7alpha-dihydroxycholesterol + NAD(+) = (24S)-7alpha,24-dihydroxycholest-4-en-3-one + H(+) + NADH"}
{"X":48754,"RHEA_ID":47201,"compounds":"(24S)-7alpha-dihydroxycholesterol + NAD(+) => (24S)-7alpha,24-dihydroxycholest-4-en-3-one + H(+) + NADH"}
{"X":48755,"RHEA_ID":50573,"DIRECTION":"LR","MASTER_ID":50572,"metacyc":"RXN-17868","compounds":"acetyl-CoA + N-terminal L-methionyl-L-valyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-valyl-[protein]"}
{"X":48756,"RHEA_ID":47203,"compounds":"(24S)-7alpha-dihydroxycholesterol + NAD(+) <=> (24S)-7alpha,24-dihydroxycholest-4-en-3-one + H(+) + NADH"}
{"X":48757,"RHEA_ID":47204,"compounds":"estrone + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":48758,"RHEA_ID":47205,"compounds":"estrone + O2 + reduced [NADPH--hemoprotein reductase] => 16alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":48759,"RHEA_ID":57220,"compounds":"GTP + methylglyoxal = N(2)-(1-hydroxy-2-oxopropyl)-GTP"}
{"X":48760,"RHEA_ID":60739,"compounds":"(2E,6E)-farnesal + H2O + NADP(+) <=> (2E,6E)-farnesoate + 2 H(+) + NADPH"}
{"X":48761,"RHEA_ID":47208,"compounds":"estrone + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":48762,"RHEA_ID":57223,"compounds":"GTP + methylglyoxal <=> N(2)-(1-hydroxy-2-oxopropyl)-GTP"}
{"X":48763,"RHEA_ID":50581,"DIRECTION":"LR","MASTER_ID":50580,"metacyc":"RXN-17867","compounds":"acetyl-CoA + N-terminal L-methionyl-L-lysyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-lysyl-[protein]"}
{"X":48764,"RHEA_ID":47211,"compounds":"estrone + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":48765,"RHEA_ID":47212,"compounds":"17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":48766,"RHEA_ID":47213,"compounds":"17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":48767,"RHEA_ID":47214,"compounds":"2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":48768,"RHEA_ID":57229,"compounds":"GDP + glyoxal => N(2)-(1-hydroxy-2-oxoethyl)-GDP"}
{"X":48769,"RHEA_ID":47216,"compounds":"17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxyestradiol-17beta + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":48770,"RHEA_ID":57231,"compounds":"GDP + glyoxal <=> N(2)-(1-hydroxy-2-oxoethyl)-GDP"}
{"X":48771,"RHEA_ID":47218,"compounds":"6beta-hydroxyestradiol-17beta + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":48772,"RHEA_ID":53903,"compounds":"[myosin light chain]-L-threonine + ATP <=> [myosin light chain]-O-phospho-L-threonine + ADP + H(+)"}
{"X":48773,"RHEA_ID":47220,"compounds":"3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] = 3beta,16alpha-dihydroxy-androst-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":48774,"RHEA_ID":57235,"compounds":"GDP + methylglyoxal <=> N(2)-(1-hydroxy-2-oxopropyl)-GDP"}
{"X":48775,"RHEA_ID":47222,"compounds":"3beta,16alpha-dihydroxy-androst-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":48776,"RHEA_ID":60755,"compounds":"(1R,3R)-chrysanthemoyl-CoA + (Z,S)-jasmololone <=> CoA + jasmolin I"}
{"X":48777,"RHEA_ID":47224,"compounds":"3beta-sulfooxy-androst-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] = 3beta-sulfooxy-16alpha-hydroxy-androst-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":48778,"RHEA_ID":57239,"compounds":"GMP + methylglyoxal <=> N(2)-(1-hydroxy-2-oxopropyl)-GMP"}
{"X":48779,"RHEA_ID":47226,"compounds":"3beta-sulfooxy-16alpha-hydroxy-androst-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3beta-sulfooxy-androst-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":48780,"RHEA_ID":53911,"compounds":"(2E)-butenoyl-CoA + L-lysyl-[protein] <=> CoA + H(+) + N(6)-(2E)-butenoyl-L-lysyl-[protein]"}
{"X":48781,"RHEA_ID":47228,"compounds":"docosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-docosenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":48782,"RHEA_ID":57243,"compounds":"glyoxal + GMP <=> N(2)-(1-hydroxy-2-oxoethyl)-GMP"}
{"X":48783,"RHEA_ID":47230,"compounds":"(2E)-docosenoyl-CoA + reduced [electron-transfer flavoprotein] => docosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":48784,"RHEA_ID":53915,"compounds":"butanoyl-CoA + L-lysyl-[protein] <=> CoA + H(+) + N(6)-butanoyl-L-lysyl-[protein]"}
{"X":48785,"RHEA_ID":47232,"compounds":"H(+) + oxidized [electron-transfer flavoprotein] + tetracosanoyl-CoA = (2E)-tetracosenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":48786,"RHEA_ID":57247,"compounds":"H2O + N(2)-(1-hydroxy-2-oxopropyl)-dGTP <=> dGTP + H(+) + lactate"}
{"X":48787,"RHEA_ID":47234,"compounds":"(2E)-tetracosenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + tetracosanoyl-CoA"}
{"X":48788,"RHEA_ID":57249,"compounds":"H2O + N(2)-(1-hydroxy-2-oxoethyl)-dGTP => dGTP + glycolate + H(+)"}
{"X":48789,"RHEA_ID":47236,"compounds":"eicosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":48790,"RHEA_ID":57251,"compounds":"H2O + N(2)-(1-hydroxy-2-oxoethyl)-dGTP <=> dGTP + glycolate + H(+)"}
{"X":48791,"RHEA_ID":50609,"DIRECTION":"LR","MASTER_ID":50608,"reactome":"R-HSA-2161567.2","compounds":"leukotriene B4 + NADP(+) => 12-oxo-leukotriene B4 + H(+) + NADPH"}
{"X":48792,"RHEA_ID":57253,"compounds":"H2O + N(2)-(1-hydroxy-2-oxoethyl)-GTP => glycolate + GTP + H(+)"}
{"X":48793,"RHEA_ID":47240,"compounds":"H(+) + octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":48794,"RHEA_ID":57255,"compounds":"H2O + N(2)-(1-hydroxy-2-oxoethyl)-GTP <=> glycolate + GTP + H(+)"}
{"X":48795,"RHEA_ID":50613,"compounds":"decanal + NADP(+) => (2E)-dec-2-enal + H(+) + NADPH"}
{"X":48796,"RHEA_ID":57257,"compounds":"H2O + N(2)-(1-hydroxy-2-oxopropyl)-GTP => GTP + H(+) + lactate"}
{"X":48797,"RHEA_ID":47244,"DIRECTION":"UN","MASTER_ID":47244,"ec":"2.4.1.266","compounds":"(2R)-3-phosphoglycerate + an NDP-alpha-D-glucose = (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + a ribonucleoside 5'-diphosphate + H(+)"}
{"X":48798,"RHEA_ID":57259,"compounds":"H2O + N(2)-(1-hydroxy-2-oxopropyl)-GTP <=> GTP + H(+) + lactate"}
{"X":48799,"RHEA_ID":47246,"compounds":"(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + a ribonucleoside 5'-diphosphate + H(+) => (2R)-3-phosphoglycerate + an NDP-alpha-D-glucose"}
{"X":48800,"RHEA_ID":53931,"compounds":"a tertiary amine + S-adenosyl-L-methionine <=> a methylated tertiary amine + H(+) + S-adenosyl-L-homocysteine"}
{"X":48801,"RHEA_ID":47248,"compounds":"2 [Fe(III)cytochrome c] + L-gulono-1,4-lactone = 2 [Fe(II)cytochrome c] + 3 H(+) + L-ascorbate"}
{"X":48802,"RHEA_ID":47249,"DIRECTION":"LR","MASTER_ID":47248,"metacyc":"RXN-14395","compounds":"2 [Fe(III)cytochrome c] + L-gulono-1,4-lactone => 2 [Fe(II)cytochrome c] + 3 H(+) + L-ascorbate"}
{"X":48803,"RHEA_ID":47250,"compounds":"2 [Fe(II)cytochrome c] + 3 H(+) + L-ascorbate => 2 [Fe(III)cytochrome c] + L-gulono-1,4-lactone"}
{"X":48804,"RHEA_ID":57265,"compounds":"H2O + N(2)-(1-hydroxy-2-oxoethyl)-GDP => GDP + glycolate + H(+)"}
{"X":48805,"RHEA_ID":47252,"compounds":"O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":48806,"RHEA_ID":47253,"compounds":"O2 + progesterone + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":48807,"RHEA_ID":47254,"compounds":"6beta-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + progesterone + reduced [NADPH--hemoprotein reductase]"}
{"X":48808,"RHEA_ID":57269,"compounds":"H2O + N(2)-(1-hydroxy-2-oxopropyl)-GMP => GMP + H(+) + lactate"}
{"X":48809,"RHEA_ID":47256,"compounds":"androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":48810,"RHEA_ID":57271,"compounds":"H2O + N(2)-(1-hydroxy-2-oxopropyl)-GMP <=> GMP + H(+) + lactate"}
{"X":48811,"RHEA_ID":57272,"compounds":"a 2'-deoxyguanosine in DNA + methylglyoxal = an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA"}
{"X":48812,"RHEA_ID":57273,"compounds":"a 2'-deoxyguanosine in DNA + methylglyoxal => an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA"}
{"X":48813,"RHEA_ID":47260,"compounds":"O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 16alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":48814,"RHEA_ID":47261,"compounds":"O2 + progesterone + reduced [NADPH--hemoprotein reductase] => 16alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":48815,"RHEA_ID":47262,"compounds":"16alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + progesterone + reduced [NADPH--hemoprotein reductase]"}
{"X":48816,"RHEA_ID":57277,"compounds":"a 2'-deoxyguanosine in DNA + glyoxal => an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA"}
{"X":48817,"RHEA_ID":60828,"DIRECTION":"UN","MASTER_ID":60828,"ec":"3.1.3.33","compounds":"a 5'-end triphospho-adenosine in mRNA + H2O = a 5'-end diphospho-adenosine in mRNA + H(+) + phosphate"}
{"X":48818,"RHEA_ID":57279,"compounds":"a 2'-deoxyguanosine in DNA + glyoxal <=> an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA"}
{"X":48819,"RHEA_ID":47266,"compounds":"AMP + diphosphate + pristanoyl-CoA => 2,6,10,14-tetramethylpentadecanoate + ATP + CoA"}
{"X":48820,"RHEA_ID":57281,"compounds":"a guanosine in RNA + glyoxal => an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA"}
{"X":48821,"RHEA_ID":50639,"DIRECTION":"BI","MASTER_ID":50636,"metacyc":"RXN-18195","compounds":"a 3-(omega-methylsulfanyl)alkylmalate <=> a 2-(omega-methylsulfanyl)alkylmaleate + H2O"}
{"X":48822,"RHEA_ID":47269,"compounds":"bacterioruberin => H2O + monoanhydrobacterioruberin"}
{"X":48823,"RHEA_ID":57284,"compounds":"a guanosine in RNA + methylglyoxal = an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA"}
{"X":48824,"RHEA_ID":57285,"compounds":"a guanosine in RNA + methylglyoxal => an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA"}
{"X":48825,"RHEA_ID":60836,"DIRECTION":"UN","MASTER_ID":60836,"ec":"2.7.7.50","compounds":"a 5'-end diphospho-adenosine in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + diphosphate"}
{"X":48826,"RHEA_ID":47273,"compounds":"monoanhydrobacterioruberin => bisanhydrobacterioruberin + H2O"}
{"X":48827,"RHEA_ID":57288,"compounds":"an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA + H2O = a guanosine in RNA + H(+) + lactate"}
{"X":48828,"RHEA_ID":50646,"compounds":"3-(3-methylsulfanyl)propylmalate => 2-(3-methylsulfanyl)propylmalate"}
{"X":48829,"RHEA_ID":47276,"compounds":"17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 15alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":48830,"RHEA_ID":47277,"compounds":"17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 15alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":48831,"RHEA_ID":57292,"compounds":"an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA + H2O = a guanosine in RNA + glycolate + H(+)"}
{"X":48832,"RHEA_ID":57293,"compounds":"an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA + H2O => a guanosine in RNA + glycolate + H(+)"}
{"X":48833,"RHEA_ID":60844,"DIRECTION":"UN","MASTER_ID":60844,"ec":"2.7.7.50","compounds":"a 5'-end diphospho-guanosine in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + diphosphate"}
{"X":48834,"RHEA_ID":47281,"compounds":"17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 4-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":48835,"RHEA_ID":47282,"compounds":"4-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":48836,"RHEA_ID":57297,"compounds":"an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA + H2O => a 2'-deoxyguanosine in DNA + glycolate + H(+)"}
{"X":48837,"RHEA_ID":47284,"compounds":"17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":48838,"RHEA_ID":57299,"compounds":"an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA + H2O <=> a 2'-deoxyguanosine in DNA + glycolate + H(+)"}
{"X":48839,"RHEA_ID":47286,"compounds":"6alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":48840,"RHEA_ID":57301,"compounds":"an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA + H2O => a 2'-deoxyguanosine in DNA + H(+) + lactate"}
{"X":48841,"RHEA_ID":60852,"DIRECTION":"UN","MASTER_ID":60852,"ec":"2.1.1.56","compounds":"a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-homocysteine"}
{"X":48842,"RHEA_ID":47289,"compounds":"17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 7alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":48843,"RHEA_ID":47290,"compounds":"7alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":48844,"RHEA_ID":57305,"compounds":"H2O + N(2)-(1-hydroxy-2-oxoethyl)-GMP => glycolate + GMP + H(+)"}
{"X":48845,"RHEA_ID":47292,"compounds":"estrone + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":48846,"RHEA_ID":57307,"compounds":"H2O + N(2)-(1-hydroxy-2-oxoethyl)-GMP <=> glycolate + GMP + H(+)"}
{"X":48847,"RHEA_ID":47294,"compounds":"4-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => estrone + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":48848,"RHEA_ID":57309,"compounds":"CTP + H(+) + N(5)-phospho-L-glutamine => diphosphate + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine"}
{"X":48849,"RHEA_ID":60860,"DIRECTION":"UN","MASTER_ID":60860,"ec":"2.1.1.57","compounds":"a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-adenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":48850,"RHEA_ID":57311,"compounds":"CTP + H(+) + N(5)-phospho-L-glutamine <=> diphosphate + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine"}
{"X":48851,"RHEA_ID":47298,"compounds":"(2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein] => dodecanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":48852,"RHEA_ID":47299,"compounds":"dodecanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":48853,"RHEA_ID":57314,"compounds":"cytidine 5'-diphosphoramidate + H(+) + L-glutamate => H2O + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine"}
{"X":48854,"RHEA_ID":57315,"compounds":"H2O + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine <=> cytidine 5'-diphosphoramidate + H(+) + L-glutamate"}
{"X":48855,"RHEA_ID":47302,"compounds":"(2E,9Z)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein] => (9Z)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":48856,"RHEA_ID":47303,"compounds":"(9Z)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,9Z)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":48857,"RHEA_ID":47304,"compounds":"(9Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,9Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":48858,"RHEA_ID":57319,"compounds":"ATP + cytidine 5'-diphosphoramidate <=> ADP + cytidine 3'-phospho-5'-diphosphoramidate + H(+)"}
{"X":48859,"RHEA_ID":47306,"compounds":"(2E,9Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein] => (9Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":48860,"RHEA_ID":47307,"compounds":"(9Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,9Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":48861,"RHEA_ID":57322,"compounds":"CoA + H(+) + N-terminal N-acetyl-L-(Asp/Glu)3-[protein] => acetyl-CoA + N-terminal L-(Asp/Glu)3-[protein]"}
{"X":48862,"RHEA_ID":57323,"compounds":"acetyl-CoA + N-terminal L-(Asp/Glu)3-[protein] <=> CoA + H(+) + N-terminal N-acetyl-L-(Asp/Glu)3-[protein]"}
{"X":48863,"RHEA_ID":47310,"compounds":"6alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => estrone + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":48864,"RHEA_ID":47311,"compounds":"estrone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":48865,"RHEA_ID":57326,"compounds":"CoA + H(+) + N-terminal N-acetyl-L-glutamyl-L-glutamyl-L-glutamyl-[protein] => acetyl-CoA + N-terminal L-glutamyl-L-glutamyl-L-glutamyl-[protein]"}
{"X":48866,"RHEA_ID":50684,"DIRECTION":"UN","MASTER_ID":50684,"ec":"3.5.1.123","compounds":"H2O + N(5)-phenyl-L-glutamine = aniline + H(+) + L-glutamate"}
{"X":48867,"RHEA_ID":47314,"compounds":"15alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => estrone + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":48868,"RHEA_ID":60879,"compounds":"a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O <=> a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)"}
{"X":48869,"RHEA_ID":57330,"compounds":"CoA + H(+) + N-terminal N-acetyl-L-aspartyl-L-aspartyl-L-aspartyl-[protein] => acetyl-CoA + N-terminal L-aspartyl-L-aspartyl-L-aspartyl-[protein]"}
{"X":48870,"RHEA_ID":57331,"compounds":"acetyl-CoA + N-terminal L-aspartyl-L-aspartyl-L-aspartyl-[protein] <=> CoA + H(+) + N-terminal N-acetyl-L-aspartyl-L-aspartyl-L-aspartyl-[protein]"}
{"X":48871,"RHEA_ID":47318,"compounds":"(2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + tetradecanoyl-CoA"}
{"X":48872,"RHEA_ID":47319,"compounds":"H(+) + oxidized [electron-transfer flavoprotein] + tetradecanoyl-CoA <=> (2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":48873,"RHEA_ID":47320,"compounds":"(S)-3-amino-3-phenylpropanoate + 2-oxoglutarate = 3-oxo-3-phenylpropanoate + L-glutamate"}
{"X":48874,"RHEA_ID":57335,"compounds":"H2O + 3 O2 + 3 propionate 3-nitronate <=> 3 3-oxopropanoate + 3 H(+) + H2O2 + 2 nitrate + nitrite"}
{"X":48875,"RHEA_ID":57340,"compounds":"3-hydroxy-L-kynurenine + S-adenosyl-L-methionine = 3-hydroxy-4-methyl-L-kynurenine + H(+) + S-adenosyl-L-homocysteine"}
{"X":48876,"RHEA_ID":50698,"compounds":"calcidiol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => calciol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":48877,"RHEA_ID":57342,"compounds":"3-hydroxy-4-methyl-L-kynurenine + H(+) + S-adenosyl-L-homocysteine => 3-hydroxy-L-kynurenine + S-adenosyl-L-methionine"}
{"X":48878,"RHEA_ID":57343,"compounds":"3-hydroxy-L-kynurenine + S-adenosyl-L-methionine <=> 3-hydroxy-4-methyl-L-kynurenine + H(+) + S-adenosyl-L-homocysteine"}
{"X":48879,"RHEA_ID":50701,"DIRECTION":"LR","MASTER_ID":50700,"metacyc":"RXN-18215","compounds":"calcidiol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => calcitriol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":48880,"RHEA_ID":50702,"compounds":"calcitriol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => calcidiol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":48881,"RHEA_ID":47328,"compounds":"1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+)"}
{"X":48882,"RHEA_ID":57347,"compounds":"3-hydroxy-D-kynurenine + S-adenosyl-L-methionine <=> 3-hydroxy-4-methyl-D-kynurenine + H(+) + S-adenosyl-L-homocysteine"}
{"X":48883,"RHEA_ID":47330,"compounds":"(9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+) => 1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O"}
{"X":48884,"RHEA_ID":50706,"compounds":"H(+) + NADH + propanal => 1-propanol + NAD(+)"}
{"X":48885,"RHEA_ID":47332,"compounds":"17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":48886,"RHEA_ID":47333,"compounds":"17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 16alpha,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":48887,"RHEA_ID":57352,"DIRECTION":"UN","MASTER_ID":57352,"ec":"1.14.14.158","compounds":"O2 + reduced [NADPH--hemoprotein reductase] + zeinoxanthin = H(+) + H2O + lutein + oxidized [NADPH--hemoprotein reductase]"}
{"X":48888,"RHEA_ID":50710,"compounds":"(12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O => (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione"}
{"X":48889,"RHEA_ID":57354,"compounds":"H(+) + H2O + lutein + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + zeinoxanthin"}
{"X":48890,"RHEA_ID":50712,"DIRECTION":"UN","MASTER_ID":50712,"ec":"1.14.19.49","compounds":"chloride + FADH2 + O2 + tetracycline = 7-chlorotetracycline + FAD + H(+) + 2 H2O"}
{"X":48891,"RHEA_ID":47338,"compounds":"16beta,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":48892,"RHEA_ID":50714,"compounds":"7-chlorotetracycline + FAD + H(+) + 2 H2O => chloride + FADH2 + O2 + tetracycline"}
{"X":48893,"RHEA_ID":57358,"compounds":"CO2 + H2O + hapalindole G + succinate => 2-oxoglutarate + chloride + H(+) + hapalindole U + O2"}
{"X":48894,"RHEA_ID":50716,"DIRECTION":"UN","MASTER_ID":50716,"ec":"1.14.14.35","compounds":"dimethyl sulfone + FMNH2 + O2 = FMN + formaldehyde + 2 H(+) + H2O + methanesulfinate"}
{"X":48895,"RHEA_ID":47342,"compounds":"6beta-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => estrone + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":48896,"RHEA_ID":47343,"compounds":"estrone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":48897,"RHEA_ID":47344,"compounds":"3beta-hydroxycholest-5-en-7-one + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta,26-dihydroxycholest-5-en-7-one + H2O + 2 oxidized [adrenodoxin]"}
{"X":48898,"RHEA_ID":50720,"DIRECTION":"UN","MASTER_ID":50720,"ec":"1.14.14.35","compounds":"FMNH2 + methanesulfinate + O2 = FMN + H(+) + H2O + methanesulfonate"}
{"X":48899,"RHEA_ID":47346,"compounds":"(25R)-3beta,26-dihydroxycholest-5-en-7-one + H2O + 2 oxidized [adrenodoxin] => 3beta-hydroxycholest-5-en-7-one + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}
{"X":48900,"RHEA_ID":50722,"compounds":"FMN + H(+) + H2O + methanesulfonate => FMNH2 + methanesulfinate + O2"}
{"X":48901,"RHEA_ID":57366,"compounds":"(6S)-NADHX => H2O + NADH"}
{"X":48902,"RHEA_ID":57367,"compounds":"H2O + NADH <=> (6S)-NADHX"}
{"X":48903,"RHEA_ID":50725,"DIRECTION":"LR","MASTER_ID":50724,"metacyc":"RXN-18144","compounds":"(E)-4-hydroxyphenylacetaldehyde oxime => (Z)-(4-hydroxyphenyl)acetaldehyde oxime"}
{"X":48904,"RHEA_ID":50726,"compounds":"(Z)-(4-hydroxyphenyl)acetaldehyde oxime => (E)-4-hydroxyphenylacetaldehyde oxime"}
{"X":48905,"RHEA_ID":57370,"compounds":"(6R)-NADPHX => H2O + NADPH"}
{"X":48906,"RHEA_ID":57371,"compounds":"H2O + NADPH <=> (6R)-NADPHX"}
{"X":48907,"RHEA_ID":50729,"DIRECTION":"LR","MASTER_ID":50728,"metacyc":"RXN-12240","compounds":"(Z)-(4-hydroxyphenyl)acetaldehyde oxime => 4-hydroxyphenylacetonitrile + H2O"}
{"X":48908,"RHEA_ID":50730,"compounds":"4-hydroxyphenylacetonitrile + H2O => (Z)-(4-hydroxyphenyl)acetaldehyde oxime"}
{"X":48909,"RHEA_ID":57374,"compounds":"(6S)-NADPHX => H2O + NADPH"}
{"X":48910,"RHEA_ID":47357,"compounds":"H2O + octanoate ester => an aliphatic alcohol + H(+) + octanoate"}
{"X":48911,"RHEA_ID":50733,"DIRECTION":"LR","MASTER_ID":50732,"metacyc":"1.14.13.42-RXN","compounds":"4-hydroxyphenylacetonitrile + O2 + reduced [NADPH--hemoprotein reductase] => (S)-4-hydroxymandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":48912,"RHEA_ID":50734,"compounds":"(S)-4-hydroxymandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 4-hydroxyphenylacetonitrile + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":48913,"RHEA_ID":57378,"compounds":"(S)-1-hydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":48914,"RHEA_ID":50736,"DIRECTION":"UN","MASTER_ID":50736,"ec":"1.8.5.5","compounds":"a quinone + 2 H(+) + hydrogen sulfide + sulfite = a quinol + thiosulfate"}
{"X":48915,"RHEA_ID":50737,"compounds":"a quinone + 2 H(+) + hydrogen sulfide + sulfite => a quinol + thiosulfate"}
{"X":48916,"RHEA_ID":47363,"compounds":"decanoate ester + H2O <=> an aliphatic alcohol + decanoate + H(+)"}
{"X":48917,"RHEA_ID":57382,"compounds":"(13S,14R)-1,13-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":48918,"RHEA_ID":47365,"compounds":"dodecanoate ester + H2O => an aliphatic alcohol + dodecanoate + H(+)"}
{"X":48919,"RHEA_ID":50741,"compounds":"H2O + leukotriene C4 => glycine + leukotriene F4"}
{"X":48920,"RHEA_ID":47367,"compounds":"dodecanoate ester + H2O <=> an aliphatic alcohol + dodecanoate + H(+)"}
{"X":48921,"RHEA_ID":57386,"compounds":"(13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + CoA => (13S,14R)-1,13-dihydroxy-N-methylcanadine + acetyl-CoA"}
{"X":48922,"RHEA_ID":47369,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + GDP-alpha-D-mannose => 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1->2)-D-myo-inositol] + GDP + H(+)"}
{"X":48923,"RHEA_ID":50745,"DIRECTION":"LR","MASTER_ID":50744,"metacyc":"RXN-17950","compounds":"2 glyphosate + O2 => 2 aminomethylphosphonate + 2 glyoxylate + 2 H(+)"}
{"X":48924,"RHEA_ID":50746,"compounds":"2 aminomethylphosphonate + 2 glyoxylate + 2 H(+) => 2 glyphosate + O2"}
{"X":48925,"RHEA_ID":57390,"compounds":"(13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":48926,"RHEA_ID":47373,"DIRECTION":"LR","MASTER_ID":47372,"metacyc":"GLUCOSE-DEHYDROGENASE-ACCEPTOR-RXN","compounds":"a quinone + D-glucose => a quinol + D-glucono-1,5-lactone"}
{"X":48927,"RHEA_ID":60942,"compounds":"(9Z)-16-hydroxyhexadec-9-enoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z)-hexadecenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":48928,"RHEA_ID":57393,"DIRECTION":"LR","MASTER_ID":57392,"metacyc":"RXN-13809","compounds":"(13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine => 3-O-acetyl-4'-O-demethylpapaveroxine + H(+)"}
{"X":48929,"RHEA_ID":57394,"compounds":"3-O-acetyl-4'-O-demethylpapaveroxine + H(+) => (13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine"}
{"X":48930,"RHEA_ID":50752,"compounds":"2 naphthalene-1,2,4,8-tetrol + O2 = 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+) + 2 H2O"}
{"X":48931,"RHEA_ID":60946,"compounds":"H(+) + isorhamnetin + S-adenosyl-L-homocysteine => quercetin + S-adenosyl-L-methionine"}
{"X":48932,"RHEA_ID":50754,"compounds":"2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+) + 2 H2O => 2 naphthalene-1,2,4,8-tetrol + O2"}
{"X":48933,"RHEA_ID":54064,"DIRECTION":"UN","MASTER_ID":54064,"ec":"4.2.3.175","compounds":"(2E,6E)-farnesyl diphosphate + H2O = 10-epi-cubebol + diphosphate"}
{"X":48934,"RHEA_ID":54065,"DIRECTION":"LR","MASTER_ID":54064,"metacyc":"RXN-18854","compounds":"(2E,6E)-farnesyl diphosphate + H2O => 10-epi-cubebol + diphosphate"}
{"X":48935,"RHEA_ID":60950,"compounds":"(S)-homoeriodictyol + H(+) + S-adenosyl-L-homocysteine => (S)-eriodictyol + S-adenosyl-L-methionine"}
{"X":48936,"RHEA_ID":57401,"DIRECTION":"LR","MASTER_ID":57400,"metacyc":"RXN-13811","compounds":"3-O-acetylpapaveroxine + H2O => acetate + H(+) + narcotine hemiacetal"}
{"X":48937,"RHEA_ID":47384,"compounds":"4-acetoxyphenol + H2O = acetate + H(+) + hydroquinone"}
{"X":48938,"RHEA_ID":50760,"DIRECTION":"UN","MASTER_ID":50760,"ec":"1.8.5.6","compounds":"a quinone + H2O + sulfite = a quinol + sulfate"}
{"X":48939,"RHEA_ID":60954,"compounds":"H(+) + S-adenosyl-L-homocysteine + trans-sinapate => (E)-5-hydroxyferulate + S-adenosyl-L-methionine"}
{"X":48940,"RHEA_ID":47387,"compounds":"4-acetoxyphenol + H2O <=> acetate + H(+) + hydroquinone"}
{"X":48941,"RHEA_ID":60956,"compounds":"17-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose = (9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + H(+) + UDP"}
{"X":48942,"RHEA_ID":54073,"DIRECTION":"LR","MASTER_ID":54072,"metacyc":"RXN-18863","compounds":"(2E)-geranyl diphosphate => beta-thujene + diphosphate"}
{"X":48943,"RHEA_ID":60958,"compounds":"(9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + H(+) + UDP => 17-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose"}
{"X":48944,"RHEA_ID":50766,"compounds":"4-methylamino-4-dedimethylamino-anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine => 4-amino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine"}
{"X":48945,"RHEA_ID":57409,"compounds":"(2R)-3-(3,4-dihydroxyphenyl)lactate + NAD(+) => 3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADH"}
{"X":48946,"RHEA_ID":50768,"DIRECTION":"UN","MASTER_ID":50768,"ec":"2.1.1.335","compounds":"4-methylamino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine = anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine"}
{"X":48947,"RHEA_ID":60962,"compounds":"(9Z)-18-hydroxyoctadec-9-enoate 18-O-beta-D-glucoside + H(+) + UDP => 18-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose"}
{"X":48948,"RHEA_ID":47395,"compounds":"H2O + hexadecanoate ester <=> an aliphatic alcohol + H(+) + hexadecanoate"}
{"X":48949,"RHEA_ID":47396,"compounds":"H2O + octadecanoate ester = an aliphatic alcohol + H(+) + octadecanoate"}
{"X":48950,"RHEA_ID":57415,"compounds":"AMP + diphosphate + L-tyrosinal + NADP(+) <=> ATP + H(+) + L-tyrosine + NADPH"}
{"X":48951,"RHEA_ID":50773,"DIRECTION":"LR","MASTER_ID":50772,"metacyc":"NITROETHANE-OXIDASE-RXN","compounds":"H2O + nitroethane + O2 => acetaldehyde + H(+) + H2O2 + nitrite"}
{"X":48952,"RHEA_ID":47399,"compounds":"H2O + octadecanoate ester <=> an aliphatic alcohol + H(+) + octadecanoate"}
{"X":48953,"RHEA_ID":47400,"compounds":"3-oxo-(9Z-octadecenoyl)-CoA + CoA = (7Z)-hexadecenoyl-CoA + acetyl-CoA"}
{"X":48954,"RHEA_ID":50776,"compounds":"hexanal + NADP(+) = (E)-2-hexenal + H(+) + NADPH"}
{"X":48955,"RHEA_ID":47402,"compounds":"(7Z)-hexadecenoyl-CoA + acetyl-CoA => 3-oxo-(9Z-octadecenoyl)-CoA + CoA"}
{"X":48956,"RHEA_ID":50778,"compounds":"(E)-2-hexenal + H(+) + NADPH => hexanal + NADP(+)"}
{"X":48957,"RHEA_ID":47404,"compounds":"(24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA + NAD(+) = 3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH"}
{"X":48958,"RHEA_ID":50780,"compounds":"NADP(+) + octanal = (2E)-octenal + H(+) + NADPH"}
{"X":48959,"RHEA_ID":47406,"compounds":"3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH => (24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA + NAD(+)"}
{"X":48960,"RHEA_ID":50782,"compounds":"(2E)-octenal + H(+) + NADPH => NADP(+) + octanal"}
{"X":48961,"RHEA_ID":47408,"compounds":"(24E)-3alpha,7alpha-dihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O = (24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA"}
{"X":48962,"RHEA_ID":50784,"compounds":"dodecanal + NADP(+) = (2E)-dodecenal + H(+) + NADPH"}
{"X":48963,"RHEA_ID":47410,"compounds":"(24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA => (24E)-3alpha,7alpha-dihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O"}
{"X":48964,"RHEA_ID":50786,"compounds":"(2E)-dodecenal + H(+) + NADPH => dodecanal + NADP(+)"}
{"X":48965,"RHEA_ID":47412,"DIRECTION":"UN","MASTER_ID":47412,"ec":"2.3.1.265","compounds":"1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1->2)-D-myo-inositol] + an acyl-CoA = 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1->2)-D-myo-inositol] + CoA"}
{"X":48966,"RHEA_ID":57431,"compounds":"anisole + O2 + reduced [NADH--hemoprotein reductase] <=> formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] + phenol"}
{"X":48967,"RHEA_ID":57432,"compounds":"3-methoxycatechol + O2 + reduced [NADH--hemoprotein reductase] = 1,2,3-trihydroxybenzene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]"}
{"X":48968,"RHEA_ID":50790,"compounds":"2-oxo-(3E)-pentene + H(+) + NADPH => NADP(+) + pentan-2-one"}
{"X":48969,"RHEA_ID":47416,"DIRECTION":"UN","MASTER_ID":47416,"ec":"2.4.1.245","compounds":"an NDP-alpha-D-glucose + D-glucose = a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose + H(+)"}
{"X":48970,"RHEA_ID":47417,"compounds":"an NDP-alpha-D-glucose + D-glucose => a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose + H(+)"}
{"X":48971,"RHEA_ID":47418,"compounds":"a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose + H(+) => an NDP-alpha-D-glucose + D-glucose"}
{"X":48972,"RHEA_ID":57437,"compounds":"guaethol + O2 + reduced [NADH--hemoprotein reductase] => acetaldehyde + catechol + H(+) + H2O + oxidized [NADH--hemoprotein reductase]"}
{"X":48973,"RHEA_ID":47420,"DIRECTION":"UN","MASTER_ID":47420,"ec":"1.3.99.32","compounds":"A + glutaryl-CoA = (2E)-glutaconyl-CoA + AH2"}
{"X":48974,"RHEA_ID":57439,"compounds":"guaethol + O2 + reduced [NADH--hemoprotein reductase] <=> acetaldehyde + catechol + H(+) + H2O + oxidized [NADH--hemoprotein reductase]"}
{"X":48975,"RHEA_ID":60998,"compounds":"4-methyl-2-oxopentanoate + H2O2 + NH4(+) => H2O + L-leucine + O2"}
{"X":48976,"RHEA_ID":50798,"compounds":"prostaglandin A2-S-(R)-glutathione => glutathione + prostaglandin A2"}
{"X":48977,"RHEA_ID":47424,"compounds":"(2E,9Z)-octadecadienoyl-CoA + H2O = (3S)-hydroxy-(9Z-octadecenoyl)-CoA"}
{"X":48978,"RHEA_ID":57443,"compounds":"2-methylanisole + O2 + reduced [NADH--hemoprotein reductase] <=> 2-hydroxytoluene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]"}
{"X":48979,"RHEA_ID":57444,"DIRECTION":"UN","MASTER_ID":57444,"ec":"3.4.17.17","compounds":"C-terminal L-tyrosyl-L-glutamyl-L-glutamyl-[alpha-tubulin] + H2O = C-terminal detyrosinated L-glutamyl-L-glutamyl-[alpha-tubulin] + L-tyrosine"}
{"X":48980,"RHEA_ID":50802,"compounds":"prostaglandin A2-S-(S)-glutathione => glutathione + prostaglandin A2"}
{"X":48981,"RHEA_ID":47428,"compounds":"(3S)-hydroxy-(9Z-octadecenoyl)-CoA + NAD(+) = 3-oxo-(9Z-octadecenoyl)-CoA + H(+) + NADH"}
{"X":48982,"RHEA_ID":50804,"compounds":"glutathione + prostaglandin J2 = prostaglandin J2-S-(R)-glutathione"}
{"X":48983,"RHEA_ID":61030,"compounds":"S-(2,3-dicarboxypropyl)-L-cysteinyl-[protein] => itaconate + L-cysteinyl-[protein]"}
{"X":48984,"RHEA_ID":50806,"compounds":"prostaglandin J2-S-(R)-glutathione => glutathione + prostaglandin J2"}
{"X":48985,"RHEA_ID":47432,"compounds":"(7Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,7Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":48986,"RHEA_ID":57451,"compounds":"ATP + D-tyrosine + tRNA(Tyr) <=> AMP + D-tyrosyl-tRNA(Tyr) + diphosphate + H(+)"}
{"X":48987,"RHEA_ID":57452,"compounds":"L-glutaminyl-[protein] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":48988,"RHEA_ID":50810,"compounds":"prostaglandin J2-S-(S)-glutathione => glutathione + prostaglandin J2"}
{"X":48989,"RHEA_ID":47436,"compounds":"(2E,7Z)-hexadecadienoyl-CoA + H2O = (3S)-hydroxy-(7Z-hexadecenoyl)-CoA"}
{"X":48990,"RHEA_ID":54118,"compounds":"diphosphate + pseudolaratriene => all-trans-geranylgeranyl diphosphate"}
{"X":48991,"RHEA_ID":61041,"compounds":"(+)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase] => (+)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":48992,"RHEA_ID":50814,"compounds":"1alpha-hydroxyandrost-4-ene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => androst-4-ene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":48993,"RHEA_ID":47440,"compounds":"(3S)-hydroxy-(7Z-hexadecenoyl)-CoA + NAD(+) = 3-oxo-(7Z-hexadecenoyl)-CoA + H(+) + NADH"}
{"X":48994,"RHEA_ID":57459,"compounds":"trans-sinapate + UDP-alpha-D-glucose <=> 4-O-(beta-D-glucosyl)-trans-sinapate + H(+) + UDP"}
{"X":48995,"RHEA_ID":61046,"compounds":"(-)-(R)-19-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":48996,"RHEA_ID":50818,"compounds":"5alpha-androstan-3,17-dione + NADP(+) => androst-4-ene-3,17-dione + H(+) + NADPH"}
{"X":48997,"RHEA_ID":47444,"compounds":"3-oxo-(7Z-hexadecenoyl)-CoA + CoA = (5Z)-tetradecenoyl-CoA + acetyl-CoA"}
{"X":48998,"RHEA_ID":57463,"compounds":"(E)-sinapoyl alcohol + UDP-alpha-D-glucose <=> 4-O-(beta-D-glucosyl)-trans-4-sinapoyl alcohol + H(+) + UDP"}
{"X":48999,"RHEA_ID":57464,"compounds":"(E)-caffeate + UDP-alpha-D-glucose = 1-O-[(E)-caffeoyl]-beta-D-glucose + UDP"}
{"X":49000,"RHEA_ID":50822,"DIRECTION":"RL","MASTER_ID":50820,"metacyc":"RXN66-343","reactome":"R-HSA-469659.2","compounds":"H(+) + NADPH + testosterone => 17beta-hydroxy-5alpha-androstan-3-one + NADP(+)"}
{"X":49001,"RHEA_ID":47448,"compounds":"(5Z)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,5Z)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":49002,"RHEA_ID":57467,"compounds":"(E)-caffeate + UDP-alpha-D-glucose <=> 1-O-[(E)-caffeoyl]-beta-D-glucose + UDP"}
{"X":49003,"RHEA_ID":57468,"compounds":"trans-ferulate + UDP-alpha-D-glucose = 1-O-[(E)-feruloyl]-beta-D-glucose + UDP"}
{"X":49004,"RHEA_ID":50826,"compounds":"14-hydroperoxy-(4Z,7Z,10Z,12E,16Z)-docosapentaenoate => (4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2"}
{"X":49005,"RHEA_ID":47452,"compounds":"(2E,5Z)-tetradecadienoyl-CoA + H2O = (3S)-hydroxy-(5Z-tetradecenoyl)-CoA"}
{"X":49006,"RHEA_ID":61057,"compounds":"(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + lochnericine + oxidized [NADPH--hemoprotein reductase]"}
{"X":49007,"RHEA_ID":61058,"compounds":"H(+) + H2O + lochnericine + oxidized [NADPH--hemoprotein reductase] => (-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":49008,"RHEA_ID":50830,"compounds":"(17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E)-docosapentaenoate => (4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2"}
{"X":49009,"RHEA_ID":47456,"compounds":"(3S)-hydroxy-(5Z-tetradecenoyl)-CoA + NAD(+) = 3-oxo-(5Z-tetradecenoyl)-CoA + H(+) + NADH"}
{"X":49010,"RHEA_ID":57475,"compounds":"trans-4-coumarate + UDP-alpha-D-glucose <=> 1-O-(trans-4-coumaroyl)-beta-D-glucose + UDP"}
{"X":49011,"RHEA_ID":57476,"compounds":"dodecanoate + H2O2 = 2-hydroxydodecanoate + H2O"}
{"X":49012,"RHEA_ID":50834,"compounds":"17-hydroperoxy-(7Z,10Z,13Z,15E,19Z)-docosapentaenoate => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2"}
{"X":49013,"RHEA_ID":47460,"compounds":"3-oxo-(5Z-tetradecenoyl)-CoA + CoA = (3Z)-dodecenoyl-CoA + acetyl-CoA"}
{"X":49014,"RHEA_ID":47461,"compounds":"3-oxo-(5Z-tetradecenoyl)-CoA + CoA => (3Z)-dodecenoyl-CoA + acetyl-CoA"}
{"X":49015,"RHEA_ID":57480,"compounds":"2-hydroxydodecanoate + H2O2 = 2,3-dihydroxydodecanoate + H2O"}
{"X":49016,"RHEA_ID":57481,"compounds":"2-hydroxydodecanoate + H2O2 => 2,3-dihydroxydodecanoate + H2O"}
{"X":49017,"RHEA_ID":47464,"compounds":"(3E,5Z)-tetradecadienoyl-CoA = (2E,5Z)-tetradecadienoyl-CoA"}
{"X":49018,"RHEA_ID":57483,"compounds":"2-hydroxydodecanoate + H2O2 <=> 2,3-dihydroxydodecanoate + H2O"}
{"X":49019,"RHEA_ID":57492,"compounds":"H2O + oxaloacetate + propanoyl-CoA = 2-methylcitrate + CoA + H(+)"}
{"X":49020,"RHEA_ID":50842,"compounds":"(17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2"}
{"X":49021,"RHEA_ID":47468,"compounds":"(2E,4E)-tetradecadienoyl-CoA = (3E,5Z)-tetradecadienoyl-CoA"}
{"X":49022,"RHEA_ID":47469,"compounds":"(2E,4E)-tetradecadienoyl-CoA => (3E,5Z)-tetradecadienoyl-CoA"}
{"X":49023,"RHEA_ID":57496,"compounds":"2-methylcitrate = 2-methyl-cis-aconitate + H2O"}
{"X":49024,"RHEA_ID":57497,"compounds":"2-methylcitrate => 2-methyl-cis-aconitate + H2O"}
{"X":49025,"RHEA_ID":47472,"compounds":"(2E,4E)-tetradecadienoyl-CoA + H(+) + NADPH = (3E)-tetradecenoyl-CoA + NADP(+)"}
{"X":49026,"RHEA_ID":47473,"compounds":"(2E,4E)-tetradecadienoyl-CoA + H(+) + NADPH => (3E)-tetradecenoyl-CoA + NADP(+)"}
{"X":49027,"RHEA_ID":57500,"compounds":"3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O"}
{"X":49028,"RHEA_ID":50850,"compounds":"(11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoate + A + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2"}
{"X":49029,"RHEA_ID":47476,"compounds":"(3E)-tetradecenoyl-CoA = (2E)-tetradecenoyl-CoA"}
{"X":49030,"RHEA_ID":47477,"compounds":"(3E)-tetradecenoyl-CoA => (2E)-tetradecenoyl-CoA"}
{"X":49031,"RHEA_ID":57504,"compounds":"3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate"}
{"X":49032,"RHEA_ID":57505,"compounds":"3-hydroxybutane-1,2,3-tricarboxylate => pyruvate + succinate"}
{"X":49033,"RHEA_ID":47480,"compounds":"deoxycholate + NADP(+) = 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH"}
{"X":49034,"RHEA_ID":47481,"compounds":"deoxycholate + NADP(+) => 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH"}
{"X":49035,"RHEA_ID":47482,"compounds":"12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH => deoxycholate + NADP(+)"}
{"X":49036,"RHEA_ID":57509,"compounds":"H2O + NADP(+) + staphylopine => (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate"}
{"X":49037,"RHEA_ID":47484,"compounds":"deoxycholate + NAD(+) = 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH"}
{"X":49038,"RHEA_ID":47485,"compounds":"deoxycholate + NAD(+) => 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH"}
{"X":49039,"RHEA_ID":57512,"DIRECTION":"UN","MASTER_ID":57512,"ec":"1.14.12.26","compounds":"chlorobenzene + H(+) + NADH + O2 = (1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+)"}
{"X":49040,"RHEA_ID":47487,"compounds":"deoxycholate + NAD(+) <=> 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH"}
{"X":49041,"RHEA_ID":47488,"compounds":"12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH = isodeoxycholate + NADP(+)"}
{"X":49042,"RHEA_ID":47489,"compounds":"12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH => isodeoxycholate + NADP(+)"}
{"X":49043,"RHEA_ID":57516,"DIRECTION":"UN","MASTER_ID":57516,"ec":"1.14.14.159","compounds":"dolabradiene + O2 + reduced [NADPH--hemoprotein reductase] = 15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":49044,"RHEA_ID":50866,"compounds":"9-hydroxy-(10E,12Z)-octadecadienoate + A + H2O => (9Z,12Z)-octadecadienoate + AH2 + O2"}
{"X":49045,"RHEA_ID":47492,"compounds":"12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH = isodeoxycholate + NAD(+)"}
{"X":49046,"RHEA_ID":47493,"compounds":"12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH => isodeoxycholate + NAD(+)"}
{"X":49047,"RHEA_ID":47494,"compounds":"isodeoxycholate + NAD(+) => 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH"}
{"X":49048,"RHEA_ID":50870,"compounds":"(5,12,18R)-trihydroxy-(6Z,8E,10E,14Z,16E)-eicosapentaenoate => (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2"}
{"X":49049,"RHEA_ID":47496,"DIRECTION":"UN","MASTER_ID":47496,"ec":"1.1.1.392","compounds":"lithocholate + NADP(+) = 3-oxo-5beta-cholan-24-oate + H(+) + NADPH"}
{"X":49050,"RHEA_ID":47497,"DIRECTION":"LR","MASTER_ID":47496,"metacyc":"RXN-12689","compounds":"lithocholate + NADP(+) => 3-oxo-5beta-cholan-24-oate + H(+) + NADPH"}
{"X":49051,"RHEA_ID":57524,"compounds":"a 5'-triphospho-guanosine-ribonucleotide-tRNA(His) + H2O = a 5'-phospho-guanosine-ribonucleotide-tRNA(His) + diphosphate + H(+)"}
{"X":49052,"RHEA_ID":54180,"DIRECTION":"UN","MASTER_ID":54180,"ec":"1.2.1.80","compounds":"a long-chain fatty aldehyde + holo-[ACP] + NAD(+) = a long-chain fatty acyl-[ACP] + H(+) + NADH"}
{"X":49053,"RHEA_ID":47500,"compounds":"cholate + NADP(+) = 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH"}
{"X":49054,"RHEA_ID":47501,"compounds":"cholate + NADP(+) => 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH"}
{"X":49055,"RHEA_ID":47502,"compounds":"7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH => cholate + NADP(+)"}
{"X":49056,"RHEA_ID":50878,"compounds":"a hydroxy-polyunsaturated fatty acid + H2O + NADP(+) => a hydroperoxy-polyunsaturated fatty acid + H(+) + NADPH"}
{"X":49057,"RHEA_ID":47504,"compounds":"chenodeoxycholate + NADP(+) = 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH"}
{"X":49058,"RHEA_ID":47505,"compounds":"chenodeoxycholate + NADP(+) => 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH"}
{"X":49059,"RHEA_ID":47506,"compounds":"7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH => chenodeoxycholate + NADP(+)"}
{"X":49060,"RHEA_ID":50882,"compounds":"4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+) => 4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-glycerol"}
{"X":49061,"RHEA_ID":57534,"compounds":"adenosine-5'-diphospho-5'-ribonucleotide-RNA + diphosphate => 5'-end ribonucleotide-RNA + ATP + H(+)"}
{"X":49062,"RHEA_ID":47509,"DIRECTION":"LR","MASTER_ID":47508,"metacyc":"RXN-17409","compounds":"3-oxo-5beta-cholan-24-oate + H(+) + NADH => isolithocholate + NAD(+)"}
{"X":49063,"RHEA_ID":47510,"compounds":"isolithocholate + NAD(+) => 3-oxo-5beta-cholan-24-oate + H(+) + NADH"}
{"X":49064,"RHEA_ID":47511,"compounds":"3-oxo-5beta-cholan-24-oate + H(+) + NADH <=> isolithocholate + NAD(+)"}
{"X":49065,"RHEA_ID":47512,"compounds":"7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH = isocholate + NAD(+)"}
{"X":49066,"RHEA_ID":47513,"compounds":"7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH => isocholate + NAD(+)"}
{"X":49067,"RHEA_ID":47514,"compounds":"isocholate + NAD(+) => 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH"}
{"X":49068,"RHEA_ID":47515,"compounds":"7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH <=> isocholate + NAD(+)"}
{"X":49069,"RHEA_ID":54197,"compounds":"N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":49070,"RHEA_ID":61129,"compounds":"O2 + quercetin + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + myricetin + oxidized [NADPH--hemoprotein reductase]"}
{"X":49071,"RHEA_ID":47518,"compounds":"isochenodeoxycholate + NAD(+) => 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH"}
{"X":49072,"RHEA_ID":47519,"compounds":"7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH <=> isochenodeoxycholate + NAD(+)"}
{"X":49073,"RHEA_ID":47520,"DIRECTION":"UN","MASTER_ID":47520,"ec":"1.1.1.393","compounds":"3-oxo-5beta-cholan-24-oate + H(+) + NADPH = isolithocholate + NADP(+)"}
{"X":49074,"RHEA_ID":61133,"DIRECTION":"LR","MASTER_ID":61132,"metacyc":"RXN1F-93","compounds":"(2R,3R)-dihydrokaempferol + 2-oxoglutarate + O2 => CO2 + H(+) + H2O + kaempferol + succinate"}
{"X":49075,"RHEA_ID":57548,"compounds":"(S)-beta-macrocarpene + O2 + reduced [NADPH--hemoprotein reductase] = [(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":49076,"RHEA_ID":57549,"DIRECTION":"LR","MASTER_ID":57548,"metacyc":"RXN-12656","compounds":"(S)-beta-macrocarpene + O2 + reduced [NADPH--hemoprotein reductase] => [(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":49077,"RHEA_ID":57550,"compounds":"[(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-beta-macrocarpene + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":49078,"RHEA_ID":47525,"compounds":"cholate + NAD(+) => 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH"}
{"X":49079,"RHEA_ID":57552,"compounds":"[(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + O2 + reduced [NADPH--hemoprotein reductase] = (4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":49080,"RHEA_ID":47527,"DIRECTION":"BI","MASTER_ID":47524,"metacyc":"RXN-11471","compounds":"cholate + NAD(+) <=> 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH"}
{"X":49081,"RHEA_ID":47528,"compounds":"7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH = isocholate + NADP(+)"}
{"X":49082,"RHEA_ID":50904,"compounds":"L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine"}
{"X":49083,"RHEA_ID":47530,"compounds":"isocholate + NADP(+) => 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH"}
{"X":49084,"RHEA_ID":47531,"compounds":"7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH <=> isocholate + NADP(+)"}
{"X":49085,"RHEA_ID":57558,"compounds":"2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + zealexin A1 => (4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":49086,"RHEA_ID":47533,"compounds":"chenodeoxycholate + NAD(+) => 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH"}
{"X":49087,"RHEA_ID":57560,"DIRECTION":"UN","MASTER_ID":57560,"ec":"1.14.14.161","compounds":"(+)-cis-trans-nepetalactol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 7-deoxyloganetate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}
{"X":49088,"RHEA_ID":47535,"compounds":"chenodeoxycholate + NAD(+) <=> 7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH"}
{"X":49089,"RHEA_ID":47536,"compounds":"7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH = isochenodeoxycholate + NADP(+)"}
{"X":49090,"RHEA_ID":61149,"compounds":"myricetin 3-O-alpha-L-rhamnoside + UDP-alpha-D-glucose => H(+) + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] + UDP"}
{"X":49091,"RHEA_ID":57564,"compounds":"(+)-cis-trans-nepetalactol + O2 + reduced [NADPH--hemoprotein reductase] = 7-deoxyloganetic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":49092,"RHEA_ID":47539,"compounds":"7alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH <=> isochenodeoxycholate + NADP(+)"}
{"X":49093,"RHEA_ID":57566,"compounds":"7-deoxyloganetic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-cis-trans-nepetalactol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":49094,"RHEA_ID":61153,"compounds":"(E)-caffeoyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] => CoA + myricetin 3-O-[(6-O-(E)-caffeoyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]"}
{"X":49095,"RHEA_ID":57568,"compounds":"7-deoxyloganetic alcohol + O2 + reduced [NADPH--hemoprotein reductase] = 7-deoxyloganetic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":49096,"RHEA_ID":47543,"compounds":"7-oxolithocholate + H(+) + NADPH <=> NADP(+) + ursodeoxycholate"}
{"X":49097,"RHEA_ID":57570,"compounds":"7-deoxyloganetic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 7-deoxyloganetic alcohol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":49098,"RHEA_ID":47545,"compounds":"trans-4-hydroxy-L-proline betaine => cis-4-hydroxy-D-proline betaine"}
{"X":49099,"RHEA_ID":57572,"compounds":"7-deoxyloganetic aldehyde + O2 + reduced [NADPH--hemoprotein reductase] = 7-deoxyloganetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":49100,"RHEA_ID":47547,"DIRECTION":"BI","MASTER_ID":47544,"metacyc":"RXN-15948","compounds":"trans-4-hydroxy-L-proline betaine <=> cis-4-hydroxy-D-proline betaine"}
{"X":49101,"RHEA_ID":57574,"compounds":"7-deoxyloganetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 7-deoxyloganetic aldehyde + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":49102,"RHEA_ID":47549,"compounds":"7alpha-hydroxy-3-oxochol-4-en-24-oate => 3-oxochola-4,6-dien-24-oate + H2O"}
{"X":49103,"RHEA_ID":57576,"DIRECTION":"UN","MASTER_ID":57576,"ec":"1.14.14.85","compounds":"7-deoxyloganate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + loganate + oxidized [NADPH--hemoprotein reductase]"}
{"X":49104,"RHEA_ID":47551,"compounds":"7alpha-hydroxy-3-oxochol-4-en-24-oate <=> 3-oxochola-4,6-dien-24-oate + H2O"}
{"X":49105,"RHEA_ID":47552,"compounds":"glycodeoxycholate + H2O = deoxycholate + glycine"}
{"X":49106,"RHEA_ID":47553,"compounds":"glycodeoxycholate + H2O => deoxycholate + glycine"}
{"X":49107,"RHEA_ID":57580,"compounds":"5-methylsulfanyl-D-ribulose 1-phosphate = 1-methylsulfanyl-D-ribulose 5-phosphate"}
{"X":49108,"RHEA_ID":47555,"compounds":"glycodeoxycholate + H2O <=> deoxycholate + glycine"}
{"X":49109,"RHEA_ID":57582,"compounds":"1-methylsulfanyl-D-ribulose 5-phosphate => 5-methylsulfanyl-D-ribulose 1-phosphate"}
{"X":49110,"RHEA_ID":47557,"compounds":"H2O + taurodeoxycholate => deoxycholate + taurine"}
{"X":49111,"RHEA_ID":57584,"DIRECTION":"UN","MASTER_ID":57584,"ec":"1.14.14.162","compounds":"a flavanone + O2 + reduced [NADPH--hemoprotein reductase] = a 2-hydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":49112,"RHEA_ID":47559,"compounds":"H2O + taurodeoxycholate <=> deoxycholate + taurine"}
{"X":49113,"RHEA_ID":57586,"compounds":"a 2-hydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a flavanone + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":49114,"RHEA_ID":47561,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)) => CMP + ganglioside GM1b (d18:1(4E)) + H(+)"}
{"X":49115,"RHEA_ID":57588,"compounds":"(S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] = (2S)-2-hydroxynaringenin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":49116,"RHEA_ID":47563,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)) <=> CMP + ganglioside GM1b (d18:1(4E)) + H(+)"}
{"X":49117,"RHEA_ID":57590,"compounds":"(2S)-2-hydroxynaringenin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":49118,"RHEA_ID":47565,"compounds":"a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => ganglioside GA2 (d18:1(4E)) + H(+) + UDP"}
{"X":49119,"RHEA_ID":57592,"compounds":"(S)-pinocembrin + O2 + reduced [NADPH--hemoprotein reductase] = (2S)-2-hydroxypinocembrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":49120,"RHEA_ID":57593,"DIRECTION":"LR","MASTER_ID":57592,"metacyc":"RXN-14083","compounds":"(S)-pinocembrin + O2 + reduced [NADPH--hemoprotein reductase] => (2S)-2-hydroxypinocembrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":49121,"RHEA_ID":57594,"compounds":"(2S)-2-hydroxypinocembrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-pinocembrin + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":49122,"RHEA_ID":47569,"compounds":"ganglioside GD2 (d18:1(4E)) + UDP-alpha-D-galactose => ganglioside GD1b (d18:1(4E)) + H(+) + UDP"}
{"X":49123,"RHEA_ID":47570,"compounds":"ganglioside GD1b (d18:1(4E)) + H(+) + UDP => ganglioside GD2 (d18:1(4E)) + UDP-alpha-D-galactose"}
{"X":49124,"RHEA_ID":57597,"DIRECTION":"LR","MASTER_ID":57596,"metacyc":"RXN-14077","compounds":"(S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase] => (2S)-2-hydroxyeriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":49125,"RHEA_ID":57598,"compounds":"(2S)-2-hydroxyeriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":49126,"RHEA_ID":47573,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GD1b (d18:1(4E)) => CMP + ganglioside GT1b (d18:1(4E)) + H(+)"}
{"X":49127,"RHEA_ID":47574,"compounds":"CMP + ganglioside GT1b (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GD1b (d18:1(4E))"}
{"X":49128,"RHEA_ID":57601,"DIRECTION":"LR","MASTER_ID":57600,"metacyc":"RXN-16238","compounds":"2 [Fe(II)-cytochrome b5] + a 1-hexacosanoyl-2-acyl-phosphoglycerolipid + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a 1-[(17Z)-hexacos-17-enoyl]-2-acyl-phosphoglycerolipid + 2 H2O"}
{"X":49129,"RHEA_ID":47576,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GM1b (d18:1(4E)) = CMP + ganglioside GD1c (d18:1(4E)) + H(+)"}
{"X":49130,"RHEA_ID":47577,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GM1b (d18:1(4E)) => CMP + ganglioside GD1c (d18:1(4E)) + H(+)"}
{"X":49131,"RHEA_ID":57604,"DIRECTION":"UN","MASTER_ID":57604,"ec":"1.14.19.75","compounds":"2 [Fe(II)-cytochrome b5] + a 1-tetracosanoyl-2-acyl-phosphoglycerolipid + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a 1-[(15Z)-tetracos-15-enoyl]-2-acyl-phosphoglycerolipid + 2 H2O"}
{"X":49132,"RHEA_ID":47579,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GM1b (d18:1(4E)) <=> CMP + ganglioside GD1c (d18:1(4E)) + H(+)"}
{"X":49133,"RHEA_ID":57606,"compounds":"2 [Fe(III)-cytochrome b5] + a 1-[(15Z)-tetracos-15-enoyl]-2-acyl-phosphoglycerolipid + 2 H2O => 2 [Fe(II)-cytochrome b5] + a 1-tetracosanoyl-2-acyl-phosphoglycerolipid + 2 H(+) + O2"}
{"X":49134,"RHEA_ID":47581,"compounds":"ganglioside GT3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => ganglioside GT2 (d18:1(4E)) + H(+) + UDP"}
{"X":49135,"RHEA_ID":57608,"DIRECTION":"UN","MASTER_ID":57608,"ec":"1.3.1.119","compounds":"(1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+) = 3-chlorocatechol + H(+) + NADH"}
{"X":49136,"RHEA_ID":47583,"compounds":"ganglioside GT3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> ganglioside GT2 (d18:1(4E)) + H(+) + UDP"}
{"X":49137,"RHEA_ID":47584,"compounds":"ganglioside GT2 (d18:1(4E)) + UDP-alpha-D-galactose = ganglioside GT1c (d18:1(4E)) + H(+) + UDP"}
{"X":49138,"RHEA_ID":50960,"DIRECTION":"UN","MASTER_ID":50960,"ec":"2.1.1.268","compounds":"cytidine(32) in tRNA(Thr) + S-adenosyl-L-methionine = H(+) + N(3)-methylcytidine(32) in tRNA(Thr) + S-adenosyl-L-homocysteine"}
{"X":49139,"RHEA_ID":57612,"compounds":"20 H(+) + holo-[compactin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH = 9 CO2 + 9 CoA + dihydro-ML-236C-[compactin nonaketide synthase] + 6 H2O + 11 NADP(+)"}
{"X":49140,"RHEA_ID":47587,"compounds":"ganglioside GT2 (d18:1(4E)) + UDP-alpha-D-galactose <=> ganglioside GT1c (d18:1(4E)) + H(+) + UDP"}
{"X":49141,"RHEA_ID":47588,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GT1c (d18:1(4E)) = CMP + ganglioside GQ1c (d18:1(4E)) + H(+)"}
{"X":49142,"RHEA_ID":57615,"compounds":"20 H(+) + holo-[compactin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH <=> 9 CO2 + 9 CoA + dihydro-ML-236C-[compactin nonaketide synthase] + 6 H2O + 11 NADP(+)"}
{"X":49143,"RHEA_ID":47590,"compounds":"CMP + ganglioside GQ1c (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GT1c (d18:1(4E))"}
{"X":49144,"RHEA_ID":47591,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GT1c (d18:1(4E)) <=> CMP + ganglioside GQ1c (d18:1(4E)) + H(+)"}
{"X":49145,"RHEA_ID":47592,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GQ1c (d18:1(4E)) = CMP + ganglioside GP1c (d18:1(4E)) + H(+)"}
{"X":49146,"RHEA_ID":57619,"compounds":"dihydro-ML-236C-[compactin nonaketide synthase] + H2O <=> dihydro-ML-236C carboxylate + H(+) + holo-[compactin nonaketide synthase]"}
{"X":49147,"RHEA_ID":57620,"compounds":"dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + ML-236C carboxylate + oxidized [NADPH--hemoprotein reductase]"}
{"X":49148,"RHEA_ID":47595,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GQ1c (d18:1(4E)) <=> CMP + ganglioside GP1c (d18:1(4E)) + H(+)"}
{"X":49149,"RHEA_ID":47596,"DIRECTION":"UN","MASTER_ID":47596,"ec":"2.4.1.335","compounds":"an archaeal dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate = an archaeal dolichyl 3-O-(2,3-diacetamido-2,3-dideoxy- beta-D-glucuronosyl)-N-acetyl- alpha-D-glucosaminyl phosphate + H(+) + UDP"}
{"X":49150,"RHEA_ID":47597,"compounds":"an archaeal dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate => an archaeal dolichyl 3-O-(2,3-diacetamido-2,3-dideoxy- beta-D-glucuronosyl)-N-acetyl- alpha-D-glucosaminyl phosphate + H(+) + UDP"}
{"X":49151,"RHEA_ID":57624,"compounds":"dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] = 3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":49152,"RHEA_ID":57625,"compounds":"dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] => 3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":49153,"RHEA_ID":47600,"compounds":"a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + CMP-N-acetyl-beta-neuraminate = CMP + ganglioside GM4 (d18:1(4E)) + H(+)"}
{"X":49154,"RHEA_ID":57627,"compounds":"dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] <=> 3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":49155,"RHEA_ID":57628,"compounds":"3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate = H2O + ML-236C carboxylate"}
{"X":49156,"RHEA_ID":47603,"compounds":"a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + CMP-N-acetyl-beta-neuraminate <=> CMP + ganglioside GM4 (d18:1(4E)) + H(+)"}
{"X":49157,"RHEA_ID":47604,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GQ1c (d18:1(4E)) = CMP + ganglioside GP1calpha (d18:1(4E)) + H(+)"}
{"X":49158,"RHEA_ID":57631,"compounds":"3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate <=> H2O + ML-236C carboxylate"}
{"X":49159,"RHEA_ID":57632,"compounds":"ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + ML-236A carboxylate + oxidized [NADPH--hemoprotein reductase]"}
{"X":49160,"RHEA_ID":47607,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GQ1c (d18:1(4E)) <=> CMP + ganglioside GP1calpha (d18:1(4E)) + H(+)"}
{"X":49161,"RHEA_ID":47608,"compounds":"3-(3-hydroxyphenyl)-propanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 3,3',5-trihydroxybibenzyl + 4 CO2 + 4 CoA"}
{"X":49162,"RHEA_ID":47609,"compounds":"3-(3-hydroxyphenyl)-propanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 3,3',5-trihydroxybibenzyl + 4 CO2 + 4 CoA"}
{"X":49163,"RHEA_ID":57636,"compounds":"(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + ML-236A carboxylate = compactin carboxylate + holo-[2-methylbutanoate polyketide synthase]"}
{"X":49164,"RHEA_ID":47611,"compounds":"3-(3-hydroxyphenyl)-propanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 3,3',5-trihydroxybibenzyl + 4 CO2 + 4 CoA"}
{"X":49165,"RHEA_ID":47612,"DIRECTION":"UN","MASTER_ID":47612,"ec":"2.4.1.337","compounds":"a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose = a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + H(+) + UDP"}
{"X":49166,"RHEA_ID":57639,"compounds":"(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + ML-236A carboxylate <=> compactin carboxylate + holo-[2-methylbutanoate polyketide synthase]"}
{"X":49167,"RHEA_ID":57640,"compounds":"14 H(+) + holo-[equisetin nonaketide synthase] + 8 malonyl-CoA + 8 NADPH + 2 S-adenosyl-L-methionine = (3-{(1R,2S,6S,8R)-2,8-dimethyl-3-[(E)-prop-1-enyl]-4,5-didehydrodecalin-2-yl}-3-oxopropanoyl)-[equisetin nonaketide synthase] + 8 CO2 + 8 CoA + 6 H2O + 8 NADP(+) + 2 S-adenosyl-L-homocysteine"}
{"X":49168,"RHEA_ID":57641,"DIRECTION":"LR","MASTER_ID":57640,"metacyc":"RXN-16692","compounds":"14 H(+) + holo-[equisetin nonaketide synthase] + 8 malonyl-CoA + 8 NADPH + 2 S-adenosyl-L-methionine => (3-{(1R,2S,6S,8R)-2,8-dimethyl-3-[(E)-prop-1-enyl]-4,5-didehydrodecalin-2-yl}-3-oxopropanoyl)-[equisetin nonaketide synthase] + 8 CO2 + 8 CoA + 6 H2O + 8 NADP(+) + 2 S-adenosyl-L-homocysteine"}
{"X":49169,"RHEA_ID":47616,"compounds":"ethionamide + H(+) + NADPH + O2 = ethionamide S-oxide + H2O + NADP(+)"}
{"X":49170,"RHEA_ID":47617,"compounds":"ethionamide + H(+) + NADPH + O2 => ethionamide S-oxide + H2O + NADP(+)"}
{"X":49171,"RHEA_ID":57644,"compounds":"(3-{(1R,2S,6S,8R)-2,8-dimethyl-3-[(E)-prop-1-enyl]-4,5-didehydrodecalin-2-yl}-3-oxopropanoyl)-[equisetin nonaketide synthase] + L-serine = H(+) + H2O + holo-[equisetin nonaketide synthase] + trichosetin"}
{"X":49172,"RHEA_ID":47619,"compounds":"ethionamide + H(+) + NADPH + O2 <=> ethionamide S-oxide + H2O + NADP(+)"}
{"X":49173,"RHEA_ID":47620,"compounds":"2-ethylhexyl sulfate + 2-oxoglutarate + O2 = 2-ethylhexanal + CO2 + H(+) + succinate + sulfate"}
{"X":49174,"RHEA_ID":50996,"DIRECTION":"UN","MASTER_ID":50996,"ec":"2.1.1.127","compounds":"[ribulose-1,5-bisphosphate carboxylase]-L-lysine + 3 S-adenosyl-L-methionine = [ribulose-1,5-bisphosphate carboxylase]-N(6),N(6),N(6)-trimethyl-L-lysine + 3 H(+) + 3 S-adenosyl-L-homocysteine"}
{"X":49175,"RHEA_ID":47622,"compounds":"2-ethylhexanal + CO2 + H(+) + succinate + sulfate => 2-ethylhexyl sulfate + 2-oxoglutarate + O2"}
{"X":49176,"RHEA_ID":47623,"compounds":"2-ethylhexyl sulfate + 2-oxoglutarate + O2 <=> 2-ethylhexanal + CO2 + H(+) + succinate + sulfate"}
{"X":49177,"RHEA_ID":47624,"DIRECTION":"UN","MASTER_ID":47624,"ec":"4.2.1.171","compounds":"cis-3-hydroxy-L-proline = 1-pyrroline-2-carboxylate + H2O"}
{"X":49178,"RHEA_ID":51000,"DIRECTION":"UN","MASTER_ID":51000,"ec":"2.1.1.259","compounds":"[fructose-bisphosphate aldolase]-L-lysine + 3 S-adenosyl-L-methionine = [fructose-bisphosphate aldolase]-N(6),N(6),N(6)-trimethyl-L-lysine + 3 H(+) + 3 S-adenosyl-L-homocysteine"}
{"X":49179,"RHEA_ID":57656,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GD1b = CMP + ganglioside GT1balpha + H(+)"}
{"X":49180,"RHEA_ID":57657,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GD1b => CMP + ganglioside GT1balpha + H(+)"}
{"X":49181,"RHEA_ID":47628,"compounds":"glyoxylate + H2O + propanoyl-CoA = 3-methylmalate + CoA + H(+)"}
{"X":49182,"RHEA_ID":51004,"DIRECTION":"UN","MASTER_ID":51004,"ec":"1.1.2.7","compounds":"2 [Fe(III)cytochrome cL] + a primary alcohol = 2 [Fe(II)cytochrome cL] + an aldehyde + 2 H(+)"}
{"X":49183,"RHEA_ID":57660,"DIRECTION":"UN","MASTER_ID":57660,"ec":"1.14.14.151","compounds":"(+)-valencene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (+)-nootkatone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":49184,"RHEA_ID":47631,"compounds":"glyoxylate + H2O + propanoyl-CoA <=> 3-methylmalate + CoA + H(+)"}
{"X":49185,"RHEA_ID":47632,"DIRECTION":"UN","MASTER_ID":47632,"ec":"1.4.1.25","compounds":"H2O + L-arginine + NAD(+) = 5-guanidino-2-oxopentanoate + H(+) + NADH + NH4(+)"}
{"X":49186,"RHEA_ID":51008,"DIRECTION":"UN","MASTER_ID":51008,"ec":"1.1.2.7","compounds":"2 [Fe(III)cytochrome cL] + methanol = 2 [Fe(II)cytochrome cL] + formaldehyde + 2 H(+)"}
{"X":49187,"RHEA_ID":57664,"compounds":"(+)-valencene + O2 + reduced [NADPH--hemoprotein reductase] = alpha-nootkatol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":49188,"RHEA_ID":57665,"DIRECTION":"LR","MASTER_ID":57664,"metacyc":"RXN-19787","compounds":"(+)-valencene + O2 + reduced [NADPH--hemoprotein reductase] => alpha-nootkatol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":49189,"RHEA_ID":47636,"DIRECTION":"UN","MASTER_ID":47636,"ec":"1.4.1.25","compounds":"H2O + L-arginine + NADP(+) = 5-guanidino-2-oxopentanoate + H(+) + NADPH + NH4(+)"}
{"X":49190,"RHEA_ID":57668,"compounds":"alpha-nootkatol + O2 + reduced [NADPH--hemoprotein reductase] = (+)-nootkatone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":49191,"RHEA_ID":57669,"DIRECTION":"LR","MASTER_ID":57668,"metacyc":"RXN-19788","compounds":"alpha-nootkatol + O2 + reduced [NADPH--hemoprotein reductase] => (+)-nootkatone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":49192,"RHEA_ID":47640,"compounds":"adenosine(1785)/adenosine(1786) in 18S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1785)/N(6)-dimethyladenosine(1786) in 18S rRNA + 4 S-adenosyl-L-homocysteine"}
{"X":49193,"RHEA_ID":51015,"compounds":"a monoacyl-sn-glycero-3-phosphocholine + H2O <=> a monoacylglycerol + H(+) + phosphocholine"}
{"X":49194,"RHEA_ID":57672,"DIRECTION":"UN","MASTER_ID":57672,"ec":"1.14.14.151","compounds":"(+)-5-epi-aristolochene + O2 + reduced [NADPH--hemoprotein reductase] = 2beta-hydroxy-5-epi-aristolochene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":49195,"RHEA_ID":47643,"compounds":"adenosine(1785)/adenosine(1786) in 18S rRNA + 4 S-adenosyl-L-methionine <=> 4 H(+) + N(6)-dimethyladenosine(1785)/N(6)-dimethyladenosine(1786) in 18S rRNA + 4 S-adenosyl-L-homocysteine"}
{"X":49196,"RHEA_ID":47644,"compounds":"adenosine(1914)/adenosine(1915) in 18S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1914)/N(6)-dimethyladenosine(1915) in 18S rRNA + 4 S-adenosyl-L-homocysteine"}
{"X":49197,"RHEA_ID":61257,"compounds":"H2O + L-cysteine + O2 => 3-mercaptopyruvate + H2O2 + NH4(+)"}
{"X":49198,"RHEA_ID":57676,"DIRECTION":"UN","MASTER_ID":57676,"ec":"1.14.14.151","compounds":"4-epi-eremophilene + O2 + reduced [NADPH--hemoprotein reductase] = 4-epi-eremophilene-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":49199,"RHEA_ID":57677,"compounds":"4-epi-eremophilene + O2 + reduced [NADPH--hemoprotein reductase] => 4-epi-eremophilene-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":49200,"RHEA_ID":47648,"compounds":"D-ribitol 5-phosphate + H2O = phosphate + ribitol"}
{"X":49201,"RHEA_ID":51023,"DIRECTION":"BI","MASTER_ID":51020,"metacyc":"RXN-11333","compounds":"2 [Fe(III)cytochrome c] + a primary alcohol <=> 2 [Fe(II)cytochrome c] + an aldehyde + 2 H(+)"}
{"X":49202,"RHEA_ID":57680,"DIRECTION":"UN","MASTER_ID":57680,"ec":"1.14.19.76","compounds":"a flavanone + O2 + reduced [NADPH--hemoprotein reductase] = a flavone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":49203,"RHEA_ID":47651,"compounds":"D-ribitol 5-phosphate + H2O <=> phosphate + ribitol"}
{"X":49204,"RHEA_ID":47652,"compounds":"D-ribitol 1-phosphate + H2O = phosphate + ribitol"}
{"X":49205,"RHEA_ID":61265,"compounds":"H2O + L-alanine + O2 => H2O2 + NH4(+) + pyruvate"}
{"X":49206,"RHEA_ID":57688,"compounds":"apo-[corrinoid adenosyltransferase] + cob(II)inamide = cob(II)inamide--[corrinoid adenosyltransferase]"}
{"X":49207,"RHEA_ID":47655,"compounds":"D-ribitol 1-phosphate + H2O <=> phosphate + ribitol"}
{"X":49208,"RHEA_ID":47656,"compounds":"acetyl-CoA + L-methionine sulfone = CoA + H(+) + N-acetyl-L-methionine sulfone"}
{"X":49209,"RHEA_ID":51031,"compounds":"2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 <=> 7-chloroindole-3-pyruvate imine dimer + 2 H2O"}
{"X":49210,"RHEA_ID":47658,"compounds":"CoA + H(+) + N-acetyl-L-methionine sulfone => acetyl-CoA + L-methionine sulfone"}
{"X":49211,"RHEA_ID":47659,"compounds":"acetyl-CoA + L-methionine sulfone <=> CoA + H(+) + N-acetyl-L-methionine sulfone"}
{"X":49212,"RHEA_ID":47660,"compounds":"acetyl-CoA + L-methionine sulfoximine = CoA + H(+) + N-acetyl-L-methionine sulfoximine"}
{"X":49213,"RHEA_ID":57695,"compounds":"2 cob(II)inamide--[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] <=> 2 cob(I)inamide--[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":49214,"RHEA_ID":57696,"compounds":"ATP + cob(I)inamide--[corrinoid adenosyltransferase] = adenosylcob(III)inamide + apo-[corrinoid adenosyltransferase] + triphosphate"}
{"X":49215,"RHEA_ID":47663,"compounds":"acetyl-CoA + L-methionine sulfoximine <=> CoA + H(+) + N-acetyl-L-methionine sulfoximine"}
{"X":49216,"RHEA_ID":47664,"compounds":"H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD(+) = 2''-O-glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide"}
{"X":49217,"RHEA_ID":57699,"compounds":"ATP + cob(I)inamide--[corrinoid adenosyltransferase] <=> adenosylcob(III)inamide + apo-[corrinoid adenosyltransferase] + triphosphate"}
{"X":49218,"RHEA_ID":61278,"compounds":"5-amino-2-oxopentanoate + H2O2 + NH4(+) => H2O + L-ornithine + O2"}
{"X":49219,"RHEA_ID":47667,"compounds":"H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD(+) <=> 2''-O-glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide"}
{"X":49220,"RHEA_ID":47668,"compounds":"H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide"}
{"X":49221,"RHEA_ID":47669,"compounds":"H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) => 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide"}
{"X":49222,"RHEA_ID":61282,"compounds":"H2O2 + NH4(+) + succinate semialdehyde => 4-aminobutanoate + H2O + O2"}
{"X":49223,"RHEA_ID":47671,"compounds":"H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide"}
{"X":49224,"RHEA_ID":47672,"compounds":"H2O + N(6)-malonyl-L-lysyl-[protein] + NAD(+) = 2''-O-malonyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide"}
{"X":49225,"RHEA_ID":57707,"compounds":"(2R)-3-(3,4-dihydroxyphenyl)lactate + NADP(+) <=> 3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADPH"}
{"X":49226,"RHEA_ID":61286,"compounds":"(2R)-2-amino-2-carboxylatoethyl-disulfanyl-oxopropanoate + H2O2 + NH4(+) => H2O + L-cystine + O2"}
{"X":49227,"RHEA_ID":47675,"compounds":"H2O + N(6)-malonyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-malonyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide"}
{"X":49228,"RHEA_ID":47676,"compounds":"ATP + N-acetyl-D-galactosamine = ADP + H(+) + N-acetyl-D-galactosamine 6-phosphate"}
{"X":49229,"RHEA_ID":47677,"DIRECTION":"LR","MASTER_ID":47676,"metacyc":"RXN-13547","compounds":"ATP + N-acetyl-D-galactosamine => ADP + H(+) + N-acetyl-D-galactosamine 6-phosphate"}
{"X":49230,"RHEA_ID":51052,"DIRECTION":"UN","MASTER_ID":51052,"ec":"1.3.99.4","compounds":"5alpha-androstan-3,17-dione + A = 5alpha-androst-1-ene-3,17-dione + AH2"}
{"X":49231,"RHEA_ID":47679,"compounds":"ATP + N-acetyl-D-galactosamine <=> ADP + H(+) + N-acetyl-D-galactosamine 6-phosphate"}
{"X":49232,"RHEA_ID":47680,"compounds":"D-galactosamine 6-phosphate + H2O = D-tagatose 6-phosphate + NH4(+)"}
{"X":49233,"RHEA_ID":57715,"compounds":"(E)-sinapoaldehyde + UDP-alpha-D-glucose <=> 4-O-(beta-D-glucosyl)-4-trans-sinapoyl aldehyde + H(+) + UDP"}
{"X":49234,"RHEA_ID":47682,"compounds":"D-tagatose 6-phosphate + NH4(+) => D-galactosamine 6-phosphate + H2O"}
{"X":49235,"RHEA_ID":57717,"compounds":"hydrogencarbonate + NH4(+) => carbamate + H(+) + H2O"}
{"X":49236,"RHEA_ID":47684,"DIRECTION":"UN","MASTER_ID":47684,"ec":"2.4.1.333","compounds":"[(1->2)-beta-D-glucosyl](n) + phosphate = [(1->2)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate"}
{"X":49237,"RHEA_ID":47685,"compounds":"[(1->2)-beta-D-glucosyl](n) + phosphate => [(1->2)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate"}
{"X":49238,"RHEA_ID":51060,"DIRECTION":"UN","MASTER_ID":51060,"ec":"1.3.99.5","compounds":"5alpha-androst-1-ene-3,17-dione + A = AH2 + androsta-1,4-diene-3,17-dione"}
{"X":49239,"RHEA_ID":51061,"compounds":"5alpha-androst-1-ene-3,17-dione + A => AH2 + androsta-1,4-diene-3,17-dione"}
{"X":49240,"RHEA_ID":47688,"compounds":"cis-4-hydroxy-L-proline + NADP(+) = Delta(1)-pyrroline-(4S)-hydroxy-2-carboxylate + 2 H(+) + NADPH"}
{"X":49241,"RHEA_ID":57723,"DIRECTION":"BI","MASTER_ID":57720,"ecocyc":"ATPSYN-RXN","metacyc":"ATPSYN-RXN","compounds":"ATP + 4 H(+)(in) + H2O <=> ADP + 5 H(+)(out) + phosphate"}
{"X":49242,"RHEA_ID":51064,"compounds":"3'-phosphoadenylyl sulfate + lithocholate = adenosine 3',5'-bisphosphate + H(+) + lithocholate sulfate"}
{"X":49243,"RHEA_ID":47691,"compounds":"cis-4-hydroxy-L-proline + NADP(+) <=> Delta(1)-pyrroline-(4S)-hydroxy-2-carboxylate + 2 H(+) + NADPH"}
{"X":49244,"RHEA_ID":47692,"compounds":"AH2 + neomycin C + S-adenosyl-L-methionine = 5'-deoxyadenosine + A + H(+) + L-methionine + neomycin B"}
{"X":49245,"RHEA_ID":57727,"compounds":"H(+) + 2 Na(+)(in) + oxaloacetate <=> CO2 + 2 Na(+)(out) + pyruvate"}
{"X":49246,"RHEA_ID":51068,"compounds":"(2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + pyruvate = (3S,5R,10R,12S,14S,15R,16R)-3,5,10,14,15-pentahydroxy-12,16-dimethylicosan-2-one + L-alanine"}
{"X":49247,"RHEA_ID":57729,"DIRECTION":"LR","MASTER_ID":57728,"metacyc":"RXN-19902","compounds":"H(+) + trans-aconitate => CO2 + itaconate"}
{"X":49248,"RHEA_ID":47696,"compounds":"(2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + H2O = (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + phosphate"}
{"X":49249,"RHEA_ID":61309,"DIRECTION":"LR","MASTER_ID":61308,"metacyc":"RXN-8962","compounds":"(+)-(R)-germacrene A + O2 + reduced [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":49250,"RHEA_ID":57732,"compounds":"A + all-trans-7,8-dihydroretinol = AH2 + all-trans-retinol"}
{"X":49251,"RHEA_ID":47699,"compounds":"(2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + H2O <=> (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + phosphate"}
{"X":49252,"RHEA_ID":61312,"compounds":"germacra-1(10),4,11(13)-trien-12-ol + O2 + reduced [NADPH--hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":49253,"RHEA_ID":57735,"compounds":"A + all-trans-7,8-dihydroretinol <=> AH2 + all-trans-retinol"}
{"X":49254,"RHEA_ID":57736,"compounds":"A + all-trans-3,4-didehydro-13,14-dihydroretinol = AH2 + all-trans-3,4-didehydroretinol"}
{"X":49255,"RHEA_ID":47703,"compounds":"H(+) + ketocytochalasin + NADPH + O2 <=> H2O + iso-precytochalasin + NADP(+)"}
{"X":49256,"RHEA_ID":47704,"compounds":"H(+) + iso-precytochalasin + NADPH + O2 = cytochalasin Z16 + H2O + NADP(+)"}
{"X":49257,"RHEA_ID":57739,"compounds":"A + all-trans-3,4-didehydro-13,14-dihydroretinol <=> AH2 + all-trans-3,4-didehydroretinol"}
{"X":49258,"RHEA_ID":47706,"compounds":"cytochalasin Z16 + H2O + NADP(+) => H(+) + iso-precytochalasin + NADPH + O2"}
{"X":49259,"RHEA_ID":47707,"compounds":"H(+) + iso-precytochalasin + NADPH + O2 <=> cytochalasin Z16 + H2O + NADP(+)"}
{"X":49260,"RHEA_ID":47708,"compounds":"ADP + alpha-D-glucose 1-phosphate + H(+) = ADP-alpha-D-glucose + phosphate"}
{"X":49261,"RHEA_ID":57743,"compounds":"a 2,3-saturated meromycolyl-[ACP] + NAD(+) <=> a trans-Delta(2)-meromycolyl-[ACP] + H(+) + NADH"}
{"X":49262,"RHEA_ID":47710,"compounds":"ADP-alpha-D-glucose + phosphate => ADP + alpha-D-glucose 1-phosphate + H(+)"}
{"X":49263,"RHEA_ID":47711,"compounds":"ADP + alpha-D-glucose 1-phosphate + H(+) <=> ADP-alpha-D-glucose + phosphate"}
{"X":49264,"RHEA_ID":47712,"compounds":"trans-3-hydroxy-L-proline = cis-3-hydroxy-D-proline"}
{"X":49265,"RHEA_ID":57747,"compounds":"[protein]-disulfide + phylloquinol <=> [protein]-dithiol + phylloquinone"}
{"X":49266,"RHEA_ID":57748,"DIRECTION":"UN","MASTER_ID":57748,"ec":"2.3.1.292","compounds":"2 (S)-methylmalonyl-CoA + 10 H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 3 malonyl-CoA + 5 NADPH = C32-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)"}
{"X":49267,"RHEA_ID":47715,"compounds":"trans-3-hydroxy-L-proline <=> cis-3-hydroxy-D-proline"}
{"X":49268,"RHEA_ID":47716,"compounds":"4-pregnen-20,21-diol-3-one + NAD(+) = 21-hydroxyprogesterone + H(+) + NADH"}
{"X":49269,"RHEA_ID":57751,"compounds":"2 (S)-methylmalonyl-CoA + 10 H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 3 malonyl-CoA + 5 NADPH <=> C32-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)"}
{"X":49270,"RHEA_ID":57752,"DIRECTION":"UN","MASTER_ID":57752,"ec":"2.3.1.292","compounds":"2 (S)-methylmalonyl-CoA + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH = C34-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)"}
{"X":49271,"RHEA_ID":47719,"DIRECTION":"BI","MASTER_ID":47716,"ecocyc":"RXN-15607","metacyc":"RXN-15607","compounds":"4-pregnen-20,21-diol-3-one + NAD(+) <=> 21-hydroxyprogesterone + H(+) + NADH"}
{"X":49272,"RHEA_ID":47720,"compounds":"H(+) + H2O + isoguanine = NH4(+) + xanthine"}
{"X":49273,"RHEA_ID":61333,"compounds":"ATP + H2O + indoxyl sulfate(in) => ADP + H(+) + indoxyl sulfate(out) + phosphate"}
{"X":49274,"RHEA_ID":47722,"compounds":"NH4(+) + xanthine => H(+) + H2O + isoguanine"}
{"X":49275,"RHEA_ID":47723,"compounds":"H(+) + H2O + isoguanine <=> NH4(+) + xanthine"}
{"X":49276,"RHEA_ID":47724,"DIRECTION":"UN","MASTER_ID":47724,"ec":"4.3.2.7","compounds":"glutathione = 5-oxo-L-proline + L-cysteinylglycine"}
{"X":49277,"RHEA_ID":57759,"compounds":"2 (S)-methylmalonyl-CoA + 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH <=> C35-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)"}
{"X":49278,"RHEA_ID":57760,"DIRECTION":"UN","MASTER_ID":57760,"ec":"2.3.1.292","compounds":"2 (S)-methylmalonyl-CoA + 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH = C37-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)"}
{"X":49279,"RHEA_ID":57761,"DIRECTION":"LR","MASTER_ID":57760,"metacyc":"RXN-17246","compounds":"2 (S)-methylmalonyl-CoA + 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH => C37-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)"}
{"X":49280,"RHEA_ID":47728,"compounds":"(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP-alpha-D-mannose = (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + GDP + H(+)"}
{"X":49281,"RHEA_ID":61341,"DIRECTION":"LR","MASTER_ID":61340,"metacyc":"METHYLMALONYL-COA-DECARBOXYLASE-RXN","compounds":"(S)-methylmalonyl-CoA + H(+) => CO2 + propanoyl-CoA"}
{"X":49282,"RHEA_ID":47730,"compounds":"(2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + GDP + H(+) => (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP-alpha-D-mannose"}
{"X":49283,"RHEA_ID":47731,"DIRECTION":"BI","MASTER_ID":47728,"metacyc":"RXN-12040","compounds":"(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP-alpha-D-mannose <=> (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + GDP + H(+)"}
{"X":49284,"RHEA_ID":47732,"compounds":"cytidine(1400) in 16S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(1400) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":49285,"RHEA_ID":57767,"compounds":"2,6-dinitrotoluene + NADH + O2 <=> 3-methyl-4-nitrocatechol + NAD(+) + nitrite"}
{"X":49286,"RHEA_ID":47734,"compounds":"5-methylcytidine(1400) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1400) in 16S rRNA + S-adenosyl-L-methionine"}
{"X":49287,"RHEA_ID":47735,"compounds":"cytidine(1400) in 16S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(1400) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":49288,"RHEA_ID":47736,"compounds":"cytidine(1404) in 16S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(1404) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":49289,"RHEA_ID":61349,"compounds":"ATP + estrone 3-sulfate(in) + H2O => ADP + estrone 3-sulfate(out) + H(+) + phosphate"}
{"X":49290,"RHEA_ID":57772,"DIRECTION":"UN","MASTER_ID":57772,"ec":"1.14.12.23","compounds":"3-nitrotoluene + NADH + O2 = 4-methylcatechol + NAD(+) + nitrite"}
{"X":49291,"RHEA_ID":47739,"compounds":"cytidine(1404) in 16S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(1404) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":49292,"RHEA_ID":47740,"DIRECTION":"UN","MASTER_ID":47740,"ec":"2.5.1.130","compounds":"1,4-dioxo-2-naphthoate + H(+) + phytyl diphosphate = CO2 + demethylphylloquinone + diphosphate"}
{"X":49293,"RHEA_ID":61353,"compounds":"ATP + H2O + riboflavin(in) => ADP + H(+) + phosphate + riboflavin(out)"}
{"X":49294,"RHEA_ID":47742,"compounds":"CO2 + demethylphylloquinone + diphosphate => 1,4-dioxo-2-naphthoate + H(+) + phytyl diphosphate"}
{"X":49295,"RHEA_ID":47744,"DIRECTION":"UN","MASTER_ID":47744,"ec":"1.6.5.12","compounds":"demethylphylloquinone + H(+) + NADPH = demethylphylloquinol + NADP(+)"}
{"X":49296,"RHEA_ID":57779,"compounds":"2-chloro-6-nitrotoluene + NADH + O2 <=> 4-chloro-3-methylcatechol + NAD(+) + nitrite"}
{"X":49297,"RHEA_ID":47746,"compounds":"demethylphylloquinol + NADP(+) => demethylphylloquinone + H(+) + NADPH"}
{"X":49298,"RHEA_ID":57781,"compounds":"2-chloro-4-nitrotoluene + NADH + O2 => 3-chloro-4-methylcatechol + NAD(+) + nitrite"}
{"X":49299,"RHEA_ID":47748,"DIRECTION":"UN","MASTER_ID":47748,"ec":"7.2.1.1","compounds":"a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n Na(+)(out) + NAD(+)"}
{"X":49300,"RHEA_ID":57783,"compounds":"2-chloro-4-nitrotoluene + NADH + O2 <=> 3-chloro-4-methylcatechol + NAD(+) + nitrite"}
{"X":49301,"RHEA_ID":47750,"compounds":"a ubiquinol + n Na(+)(out) + NAD(+) => a ubiquinone + H(+) + n Na(+)(in) + NADH"}
{"X":49302,"RHEA_ID":47751,"compounds":"a ubiquinone + H(+) + n Na(+)(in) + NADH <=> a ubiquinol + n Na(+)(out) + NAD(+)"}
{"X":49303,"RHEA_ID":47752,"compounds":"5-hydroxy-3-methyl-L-tyrosine + S-adenosyl-L-methionine = 5-hydroxy-3-methyl-O-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine"}
{"X":49304,"RHEA_ID":51127,"compounds":"uridine in snRNA <=> pseudouridine in snRNA"}
{"X":49305,"RHEA_ID":57788,"DIRECTION":"UN","MASTER_ID":57788,"ec":"1.14.12.23","metacyc":"RXN-16800","compounds":"1,3-dinitrobenzene + NADH + O2 = 4-nitrocatechol + H(+) + NAD(+) + nitrite"}
{"X":49306,"RHEA_ID":47755,"compounds":"5-hydroxy-3-methyl-L-tyrosine + S-adenosyl-L-methionine <=> 5-hydroxy-3-methyl-O-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine"}
{"X":49307,"RHEA_ID":47756,"compounds":"guanosine(1370) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(1370) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":49308,"RHEA_ID":51131,"compounds":"A + an aliphatic amine + H2O <=> AH2 + an aldehyde + NH4(+)"}
{"X":49309,"RHEA_ID":57792,"DIRECTION":"UN","MASTER_ID":57792,"ec":"1.14.12.23","metacyc":"RXN-16799","compounds":"3,4-dinitrotoluene + NADH + O2 = 4-methyl-6-nitrocatechol + NAD(+) + nitrite"}
{"X":49310,"RHEA_ID":47759,"compounds":"guanosine(1370) in 16S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(1370) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":49311,"RHEA_ID":47760,"compounds":"a uridine in 21S rRNA + S-adenosyl-L-methionine = a 2'-O-methyluridine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":49312,"RHEA_ID":57795,"compounds":"3,4-dinitrotoluene + NADH + O2 <=> 4-methyl-6-nitrocatechol + NAD(+) + nitrite"}
{"X":49313,"RHEA_ID":47762,"compounds":"a 2'-O-methyluridine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine => a uridine in 21S rRNA + S-adenosyl-L-methionine"}
{"X":49314,"RHEA_ID":47763,"compounds":"a uridine in 21S rRNA + S-adenosyl-L-methionine <=> a 2'-O-methyluridine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":49315,"RHEA_ID":47764,"compounds":"S-adenosyl-L-methionine + uridine(1369) in 16S rRNA = 2'-O-methyluridine(1369) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":49316,"RHEA_ID":57799,"compounds":"4-nitrotoluene + NADH + O2 <=> 4-methylcatechol + NAD(+) + nitrite"}
{"X":49317,"RHEA_ID":47766,"compounds":"2'-O-methyluridine(1369) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(1369) in 16S rRNA"}
{"X":49318,"RHEA_ID":47767,"compounds":"S-adenosyl-L-methionine + uridine(1369) in 16S rRNA <=> 2'-O-methyluridine(1369) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":49319,"RHEA_ID":47768,"compounds":"guanosine(2270) in 21S rRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(2270) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":49320,"RHEA_ID":57803,"compounds":"2,3-dinitrotoluene + NADH + O2 <=> 4-methyl-3-nitrocatechol + H(+) + NAD(+) + nitrite"}
{"X":49321,"RHEA_ID":57804,"DIRECTION":"UN","MASTER_ID":57804,"ec":"1.14.12.23","metacyc":"RXN-16795","compounds":"1-chloro-3-nitrobenzene + NADH + O2 = 4-chlorocatechol + NAD(+) + nitrite"}
{"X":49322,"RHEA_ID":47771,"compounds":"guanosine(2270) in 21S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(2270) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":49323,"RHEA_ID":47772,"compounds":"a guanosine in 21S rRNA + S-adenosyl-L-methionine = a 2'-O-methylguanosine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":49324,"RHEA_ID":57807,"compounds":"1-chloro-3-nitrobenzene + NADH + O2 <=> 4-chlorocatechol + NAD(+) + nitrite"}
{"X":49325,"RHEA_ID":47774,"compounds":"a 2'-O-methylguanosine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine => a guanosine in 21S rRNA + S-adenosyl-L-methionine"}
{"X":49326,"RHEA_ID":47775,"compounds":"a guanosine in 21S rRNA + S-adenosyl-L-methionine <=> a 2'-O-methylguanosine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":49327,"RHEA_ID":47776,"compounds":"guanosine(1145) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(1145) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":49328,"RHEA_ID":57811,"compounds":"1-chloro-3-nitrobenzene + NADH + O2 <=> 3-chlorocatechol + NAD(+) + nitrite"}
{"X":49329,"RHEA_ID":47778,"compounds":"2'-O-methylguanosine(1145) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(1145) in 16S rRNA + S-adenosyl-L-methionine"}
{"X":49330,"RHEA_ID":47779,"compounds":"guanosine(1145) in 16S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(1145) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":49331,"RHEA_ID":47780,"compounds":"a cytidine in 25S rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in 25S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":49332,"RHEA_ID":51155,"compounds":"2 a thiol + L-cysteinyl-[sulfatase] + O2 <=> 3-oxo-L-alanyl-[sulfatase] + an organic disulfide + H(+) + H2O + hydrogen sulfide"}
{"X":49333,"RHEA_ID":47782,"compounds":"a 5-methylcytidine in 25S rRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in 25S rRNA + S-adenosyl-L-methionine"}
{"X":49334,"RHEA_ID":47783,"compounds":"a cytidine in 25S rRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in 25S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":49335,"RHEA_ID":47784,"compounds":"cytidine(3782) in 28S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(3782) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":49336,"RHEA_ID":57819,"compounds":"dGMP + H2O <=> 2-deoxy-D-ribose 5-phosphate + guanine"}
{"X":49337,"RHEA_ID":51160,"compounds":"cytidine(60) in tRNA(Asp) + S-adenosyl-L-methionine = 5-methylcytidine(60) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine"}
{"X":49338,"RHEA_ID":47787,"compounds":"cytidine(3782) in 28S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(3782) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":49339,"RHEA_ID":47788,"compounds":"a cytidine in 28S rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in 28S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":49340,"RHEA_ID":61401,"compounds":"ATP + N(6)-(D-ribulosyl)-L-lysine => ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysine"}
{"X":49341,"RHEA_ID":57824,"compounds":"dAMP + H2O = 2-deoxy-D-ribose 5-phosphate + adenine"}
{"X":49342,"RHEA_ID":47791,"compounds":"a cytidine in 28S rRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in 28S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":49343,"RHEA_ID":47792,"compounds":"cytidine(4447) in 28S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(4447) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":49344,"RHEA_ID":57827,"compounds":"dAMP + H2O <=> 2-deoxy-D-ribose 5-phosphate + adenine"}
{"X":49345,"RHEA_ID":51168,"compounds":"(R)-adrenaline + H2O + O2 = 3,4-dihydroxymandelaldehyde + H2O2 + methylamine"}
{"X":49346,"RHEA_ID":47795,"compounds":"cytidine(4447) in 28S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(4447) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":49347,"RHEA_ID":47796,"DIRECTION":"UN","MASTER_ID":47796,"ec":"1.4.9.2","compounds":"an aralkylamine + H2O + 2 oxidized [azurin] = an aromatic aldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin]"}
{"X":49348,"RHEA_ID":57831,"compounds":"dIMP + H2O <=> 2-deoxy-D-ribose 5-phosphate + hypoxanthine"}
{"X":49349,"RHEA_ID":51172,"compounds":"cytidine(62) in tRNA(Asp) + S-adenosyl-L-methionine = 5-methylcytidine(62) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine"}
{"X":49350,"RHEA_ID":47799,"DIRECTION":"BI","MASTER_ID":47796,"metacyc":"ARALKYLAMINE-DEHYDROGENASE-RXN","compounds":"an aralkylamine + H2O + 2 oxidized [azurin] <=> an aromatic aldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin]"}
{"X":49351,"RHEA_ID":47800,"compounds":"4-methylsulfanyl-2-oxobutanoate + an aromatic L-alpha-amino acid = an aromatic oxo-acid + L-methionine"}
{"X":49352,"RHEA_ID":61413,"compounds":"ATP + N-(D-erythrulosyl)-cadaverine => ADP + H(+) + N-(3-O-phospho-D-erythrulosyl)-cadaverine"}
{"X":49353,"RHEA_ID":51176,"compounds":"cytidine(48) in tRNA(Asp) + S-adenosyl-L-methionine = 5-methylcytidine(48) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine"}
{"X":49354,"RHEA_ID":47803,"compounds":"4-methylsulfanyl-2-oxobutanoate + an aromatic L-alpha-amino acid <=> an aromatic oxo-acid + L-methionine"}
{"X":49355,"RHEA_ID":47804,"compounds":"epothilone C + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = epothilone A + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":49356,"RHEA_ID":61417,"DIRECTION":"LR","MASTER_ID":61416,"metacyc":"RXN-20744","compounds":"(S)-8-oxocitronellyl enol => cis-trans-nepetalactol"}
{"X":49357,"RHEA_ID":51180,"compounds":"cytidine(49) in tRNA(Asp) + S-adenosyl-L-methionine = 5-methylcytidine(49) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine"}
{"X":49358,"RHEA_ID":47807,"compounds":"epothilone C + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> epothilone A + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":49359,"RHEA_ID":47808,"compounds":"epothilone D + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = epothilone B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":49360,"RHEA_ID":61421,"DIRECTION":"LR","MASTER_ID":61420,"metacyc":"RXN-20746","compounds":"(S)-8-oxocitronellyl enol => cis-cis-nepetalactol"}
{"X":49361,"RHEA_ID":61422,"compounds":"cis-cis-nepetalactol => (S)-8-oxocitronellyl enol"}
{"X":49362,"RHEA_ID":47811,"compounds":"epothilone D + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> epothilone B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":49363,"RHEA_ID":47812,"compounds":"H(+) + N(6)-(dimethylallyl)adenosine 5'-phosphate + NADPH + O2 = 9-ribosyl-trans-zeatin 5'-phosphate + H2O + NADP(+)"}
{"X":49364,"RHEA_ID":51187,"compounds":"1-octadecanoyl-sn-glycero-3-phosphoserine + H2O <=> H(+) + octadecanoate + sn-glycero-3-phospho-L-serine"}
{"X":49365,"RHEA_ID":51188,"compounds":"nitric oxide + superoxide = peroxynitrite"}
{"X":49366,"RHEA_ID":47815,"compounds":"H(+) + N(6)-(dimethylallyl)adenosine 5'-phosphate + NADPH + O2 <=> 9-ribosyl-trans-zeatin 5'-phosphate + H2O + NADP(+)"}
{"X":49367,"RHEA_ID":47816,"compounds":"H(+) + N(6)-(dimethylallyl)adenosine 5'-diphosphate + NADPH + O2 = 9-ribosyl-trans-zeatin 5'-diphosphate + H2O + NADP(+)"}
{"X":49368,"RHEA_ID":47817,"DIRECTION":"LR","MASTER_ID":47816,"metacyc":"RXN-4306","compounds":"H(+) + N(6)-(dimethylallyl)adenosine 5'-diphosphate + NADPH + O2 => 9-ribosyl-trans-zeatin 5'-diphosphate + H2O + NADP(+)"}
{"X":49369,"RHEA_ID":57851,"compounds":"2-oxoglutarate + O2 + scopoletin <=> CO2 + fraxetin + succinate"}
{"X":49370,"RHEA_ID":51190,"compounds":"peroxynitrite => nitric oxide + superoxide"}
{"X":49371,"RHEA_ID":47820,"compounds":"H(+) + N(6)-(dimethylallyl)adenosine 5'-triphosphate + NADPH + O2 = 9-ribosyl-trans-zeatin 5'-triphosphate + H2O + NADP(+)"}
{"X":49372,"RHEA_ID":47821,"DIRECTION":"LR","MASTER_ID":47820,"metacyc":"RXN-4304","compounds":"H(+) + N(6)-(dimethylallyl)adenosine 5'-triphosphate + NADPH + O2 => 9-ribosyl-trans-zeatin 5'-triphosphate + H2O + NADP(+)"}
{"X":49373,"RHEA_ID":57855,"compounds":"a pyrimidine 2'-deoxyribonucleoside 5'-phosphate + H2O <=> 2-deoxy-D-ribose 5-phosphate + a pyrimidine nucleobase"}
{"X":49374,"RHEA_ID":51194,"DIRECTION":"RL","MASTER_ID":51192,"reactome":"R-HSA-880053.2","compounds":"2-oxoglutarate + H(+) + NADPH => (R)-2-hydroxyglutarate + NADP(+)"}
{"X":49375,"RHEA_ID":47824,"compounds":"H(+) + malonyl-[ACP] + octadecanoyl-[ACP] = 3-oxoeicosanoyl-[ACP] + CO2 + holo-[ACP]"}
{"X":49376,"RHEA_ID":51196,"compounds":"chloride(out) + Na(+)(out) + serotonin(out) = chloride(in) + Na(+)(in) + serotonin(in)"}
{"X":49377,"RHEA_ID":47826,"compounds":"3-oxoeicosanoyl-[ACP] + CO2 + holo-[ACP] => H(+) + malonyl-[ACP] + octadecanoyl-[ACP]"}
{"X":49378,"RHEA_ID":51198,"DIRECTION":"RL","MASTER_ID":51196,"reactome":"R-HSA-444008.2","compounds":"chloride(in) + Na(+)(in) + serotonin(in) => chloride(out) + Na(+)(out) + serotonin(out)"}
{"X":49379,"RHEA_ID":47828,"compounds":"ganglioside GT1b + H2O = ganglioside GD1b + N-acetylneuraminate"}
{"X":49380,"RHEA_ID":51200,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-retinylidene-N-retinylethanolamine = H2O + N-retinylidene-N-retinylphosphatidylethanolamine"}
{"X":49381,"RHEA_ID":47830,"compounds":"ganglioside GD1b + N-acetylneuraminate => ganglioside GT1b + H2O"}
{"X":49382,"RHEA_ID":51202,"compounds":"H2O + N-retinylidene-N-retinylphosphatidylethanolamine => a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-retinylidene-N-retinylethanolamine"}
{"X":49383,"RHEA_ID":47832,"compounds":"ganglioside GD1a + H2O = ganglioside GM1a + N-acetylneuraminate"}
{"X":49384,"RHEA_ID":57866,"compounds":"4-hydroxy-indole-3-carbonyl nitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => indole-3-carbonyl nitrile + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":49385,"RHEA_ID":47834,"compounds":"ganglioside GM1a + N-acetylneuraminate => ganglioside GD1a + H2O"}
{"X":49386,"RHEA_ID":51206,"compounds":"12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH => 6-trans-leukotriene B4 + NADP(+)"}
{"X":49387,"RHEA_ID":47836,"DIRECTION":"UN","MASTER_ID":47836,"ec":"2.7.4.31","compounds":"[5-(aminomethyl)-3-furyl]methyl phosphate + ATP = [5-(aminomethyl)furan-3-yl]methyl diphosphate + ADP"}
{"X":49388,"RHEA_ID":57870,"compounds":"(E)-2,4-dihydroxycinnamoyl-CoA + CO2 + succinate => (E)-4-coumaroyl-CoA + 2-oxoglutarate + O2"}
{"X":49389,"RHEA_ID":47838,"compounds":"[5-(aminomethyl)furan-3-yl]methyl diphosphate + ADP => [5-(aminomethyl)-3-furyl]methyl phosphate + ATP"}
{"X":49390,"RHEA_ID":51210,"compounds":"12-oxo-20-hydroxy-leukotriene B4 + H(+) + NADPH => 20-hydroxy-leukotriene B4 + NADP(+)"}
{"X":49391,"RHEA_ID":47840,"DIRECTION":"UN","MASTER_ID":47840,"ec":"2.5.1.131","compounds":"[5-(aminomethyl)furan-3-yl]methyl diphosphate + gamma-L-glutamyltyramine = (4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine + diphosphate"}
{"X":49392,"RHEA_ID":57874,"compounds":"CoA + umbelliferone => (E)-2,4-dihydroxycinnamoyl-CoA"}
{"X":49393,"RHEA_ID":47842,"compounds":"(4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine + diphosphate => [5-(aminomethyl)furan-3-yl]methyl diphosphate + gamma-L-glutamyltyramine"}
{"X":49394,"RHEA_ID":57876,"DIRECTION":"UN","MASTER_ID":57876,"metacyc":"RXN-12501","compounds":"uridine(54) in tRNA = pseudouridine(54) in tRNA"}
{"X":49395,"RHEA_ID":47844,"DIRECTION":"UN","MASTER_ID":47844,"ec":"2.5.1.3","compounds":"2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate"}
{"X":49396,"RHEA_ID":57878,"compounds":"pseudouridine(54) in tRNA => uridine(54) in tRNA"}
{"X":49397,"RHEA_ID":47846,"compounds":"CO2 + diphosphate + thiamine phosphate => 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+)"}
{"X":49398,"RHEA_ID":51218,"compounds":"3beta-sulfooxy-androst-5-en-17-one + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3beta-hydroxyandrost-5-en-17-one"}
{"X":49399,"RHEA_ID":47848,"DIRECTION":"UN","MASTER_ID":47848,"ec":"2.5.1.3","compounds":"2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate"}
{"X":49400,"RHEA_ID":57882,"compounds":"3-O-[beta-D-xylosyl-(1->4)-(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-threonyl-[protein] + H(+) + UDP => 3-O-[(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-threonyl-[protein] + UDP-alpha-D-xylose"}
{"X":49401,"RHEA_ID":47850,"compounds":"CO2 + diphosphate + thiamine phosphate => 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+)"}
{"X":49402,"RHEA_ID":51222,"compounds":"2,4-dinitrophenyl-S-glutathione + chloride + H(+) => 1-chloro-2,4-dinitrobenzene + glutathione"}
{"X":49403,"RHEA_ID":47852,"compounds":"a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + H2O = a neolactoside nLc4Cer(d18:1(4E)) + N-acetylneuraminate"}
{"X":49404,"RHEA_ID":57886,"compounds":"H(+) + Na(+)(out) + 2 phosphate => diphosphate + H2O + Na(+)(in)"}
{"X":49405,"RHEA_ID":47854,"compounds":"a neolactoside nLc4Cer(d18:1(4E)) + N-acetylneuraminate => a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + H2O"}
{"X":49406,"RHEA_ID":57888,"compounds":"a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)"}
{"X":49407,"RHEA_ID":47856,"compounds":"ganglioside GD1a (18:1(4E)) + H2O = ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate"}
{"X":49408,"RHEA_ID":57890,"compounds":"a quinol + 4 H(+)(out) + NAD(+) => a quinone + 5 H(+)(in) + NADH"}
{"X":49409,"RHEA_ID":47858,"compounds":"ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate => ganglioside GD1a (18:1(4E)) + H2O"}
{"X":49410,"RHEA_ID":47859,"compounds":"ganglioside GD1a (18:1(4E)) + H2O <=> ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate"}
{"X":49411,"RHEA_ID":47860,"compounds":"ganglioside GT1b (d18:1(4E)) + H2O = ganglioside GD1b (d18:1(4E)) + N-acetylneuraminate"}
{"X":49412,"RHEA_ID":47861,"compounds":"ganglioside GT1b (d18:1(4E)) + H2O => ganglioside GD1b (d18:1(4E)) + N-acetylneuraminate"}
{"X":49413,"RHEA_ID":47862,"compounds":"ganglioside GD1b (d18:1(4E)) + N-acetylneuraminate => ganglioside GT1b (d18:1(4E)) + H2O"}
{"X":49414,"RHEA_ID":47863,"compounds":"ganglioside GT1b (d18:1(4E)) + H2O <=> ganglioside GD1b (d18:1(4E)) + N-acetylneuraminate"}
{"X":49415,"RHEA_ID":47864,"compounds":"1,2,3-trioctanoylglycerol + H2O = dioctanoylglycerol + H(+) + octanoate"}
{"X":49416,"RHEA_ID":47865,"compounds":"1,2,3-trioctanoylglycerol + H2O => dioctanoylglycerol + H(+) + octanoate"}
{"X":49417,"RHEA_ID":47866,"compounds":"dioctanoylglycerol + H(+) + octanoate => 1,2,3-trioctanoylglycerol + H2O"}
{"X":49418,"RHEA_ID":57900,"compounds":"2-oxoglutarate + N(6)-methyladenosine in U6 snRNA + O2 = adenosine in U6 snRNA + CO2 + formaldehyde + succinate"}
{"X":49419,"RHEA_ID":47868,"compounds":"di-(9Z)-octadecenoylglycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)"}
{"X":49420,"RHEA_ID":51240,"compounds":"(9Z,12Z)-octadecadienoate + O2 = (13R)-hydroperoxy-(9Z,11E)-octadecadienoate"}
{"X":49421,"RHEA_ID":47870,"compounds":"(9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+) => di-(9Z)-octadecenoylglycerol + H2O"}
{"X":49422,"RHEA_ID":57904,"compounds":"2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in U6 snRNA + O2 = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in U6 snRNA + CO2 + formaldehyde + succinate"}
{"X":49423,"RHEA_ID":47872,"compounds":"ganglioside GM1a + H2O = ganglioside GA1 + N-acetylneuraminate"}
{"X":49424,"RHEA_ID":57906,"compounds":"a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in U6 snRNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in U6 snRNA + O2"}
{"X":49425,"RHEA_ID":47874,"compounds":"ganglioside GA1 + N-acetylneuraminate => ganglioside GM1a + H2O"}
{"X":49426,"RHEA_ID":57908,"compounds":"ATP + L-glutamyl-tRNA(Gln) = 5-phosphooxy-L-glutamyl-tRNA(Gln) + ADP"}
{"X":49427,"RHEA_ID":47876,"compounds":"ganglioside GD1b + H2O = ganglioside GM1a + N-acetylneuraminate"}
{"X":49428,"RHEA_ID":57910,"compounds":"5-phosphooxy-L-glutamyl-tRNA(Gln) + ADP => ATP + L-glutamyl-tRNA(Gln)"}
{"X":49429,"RHEA_ID":47878,"compounds":"ganglioside GM1a + N-acetylneuraminate => ganglioside GD1b + H2O"}
{"X":49430,"RHEA_ID":57912,"compounds":"5-phosphooxy-L-glutamyl-tRNA(Gln) + NH4(+) = H(+) + L-glutaminyl-tRNA(Gln) + phosphate"}
{"X":49431,"RHEA_ID":47880,"compounds":"dioctanoylglycerol + H2O = H(+) + octanoate + octanoylglycerol"}
{"X":49432,"RHEA_ID":51252,"compounds":"(9Z,12Z,15Z)-octadecatrienoate + O2 = (11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate"}
{"X":49433,"RHEA_ID":47882,"compounds":"H(+) + octanoate + octanoylglycerol => dioctanoylglycerol + H2O"}
{"X":49434,"RHEA_ID":57916,"compounds":"ATP + L-aspartyl-tRNA(Asn) = 4-phosphooxy-L-aspartyl-tRNA(Asn) + ADP + H(+)"}
{"X":49435,"RHEA_ID":47884,"compounds":"CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine = CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine"}
{"X":49436,"RHEA_ID":57918,"compounds":"4-phosphooxy-L-aspartyl-tRNA(Asn) + ADP + H(+) => ATP + L-aspartyl-tRNA(Asn)"}
{"X":49437,"RHEA_ID":47886,"compounds":"CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine => CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine"}
{"X":49438,"RHEA_ID":47887,"compounds":"CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine <=> CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine"}
{"X":49439,"RHEA_ID":47888,"compounds":"GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine = GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine"}
{"X":49440,"RHEA_ID":51260,"DIRECTION":"UN","MASTER_ID":51260,"ec":"1.14.19.50","compounds":"4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase] = (10bR,4aS)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":49441,"RHEA_ID":47890,"compounds":"GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine => GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine"}
{"X":49442,"RHEA_ID":51262,"compounds":"(10bR,4aS)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":49443,"RHEA_ID":47892,"compounds":"GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine = GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->6)-N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine"}
{"X":49444,"RHEA_ID":51264,"DIRECTION":"UN","MASTER_ID":51264,"ec":"1.14.19.50","compounds":"4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase] = (10bS,4aR)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":49445,"RHEA_ID":47894,"compounds":"GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->6)-N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine => GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine"}
{"X":49446,"RHEA_ID":51266,"compounds":"(10bS,4aR)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":49447,"RHEA_ID":47896,"DIRECTION":"UN","MASTER_ID":47896,"ec":"1.1.1.390","compounds":"6-sulfo-D-quinovose + NAD(+) = 6-deoxy-6-sulfo-D-glucono-1,5-lactone + H(+) + NADH"}
{"X":49448,"RHEA_ID":57930,"compounds":"ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + H(+) + L-glutamate + phosphate => ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + H2O + L-glutamine"}
{"X":49449,"RHEA_ID":47898,"compounds":"6-deoxy-6-sulfo-D-glucono-1,5-lactone + H(+) + NADH => 6-sulfo-D-quinovose + NAD(+)"}
{"X":49450,"RHEA_ID":51270,"compounds":"4'-O-methylnorbelladine + H(+) + S-adenosyl-L-homocysteine => norbelladine + S-adenosyl-L-methionine"}
{"X":49451,"RHEA_ID":47900,"compounds":"ganglioside GM3 (d18:1(4E)) + H2O = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetylneuraminate"}
{"X":49452,"RHEA_ID":51272,"compounds":"(9Z)-octadecenoyl-CoA + glycine = CoA + H(+) + N-(9Z-octadecenoyl)glycine"}
{"X":49453,"RHEA_ID":47902,"compounds":"a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetylneuraminate => ganglioside GM3 (d18:1(4E)) + H2O"}
{"X":49454,"RHEA_ID":47903,"compounds":"ganglioside GM3 (d18:1(4E)) + H2O <=> a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetylneuraminate"}
{"X":49455,"RHEA_ID":47904,"compounds":"ATP + N-(acetyl)-sphing-4-enine = ADP + H(+) + N-(acetyl)-sphing-4-enine-1-phosphate"}
{"X":49456,"RHEA_ID":51276,"compounds":"(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate = (9S)-hydroperoxy-(10E,12Z)-octadecadienoate"}
{"X":49457,"RHEA_ID":47906,"compounds":"ADP + H(+) + N-(acetyl)-sphing-4-enine-1-phosphate => ATP + N-(acetyl)-sphing-4-enine"}
{"X":49458,"RHEA_ID":47907,"compounds":"ATP + N-(acetyl)-sphing-4-enine <=> ADP + H(+) + N-(acetyl)-sphing-4-enine-1-phosphate"}
{"X":49459,"RHEA_ID":47908,"DIRECTION":"UN","MASTER_ID":47908,"ec":"3.1.1.99","compounds":"6-deoxy-6-sulfo-D-glucono-1,5-lactone + H2O = 6-deoxy-6-sulfo-D-gluconate + H(+)"}
{"X":49460,"RHEA_ID":57942,"compounds":"CO2 + 2 H2O + harderoheme III => Fe-coproporphyrin III + H(+) + H2O2"}
{"X":49461,"RHEA_ID":47910,"compounds":"6-deoxy-6-sulfo-D-gluconate + H(+) => 6-deoxy-6-sulfo-D-glucono-1,5-lactone + H2O"}
{"X":49462,"RHEA_ID":57944,"compounds":"H(+) + H2O2 + harderoheme III = CO2 + 2 H2O + heme b"}
{"X":49463,"RHEA_ID":47912,"DIRECTION":"UN","MASTER_ID":47912,"ec":"4.2.1.162","compounds":"6-deoxy-6-sulfo-D-gluconate = 2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate + H2O"}
{"X":49464,"RHEA_ID":51284,"compounds":"(11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate = (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate"}
{"X":49465,"RHEA_ID":47914,"compounds":"2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate + H2O => 6-deoxy-6-sulfo-D-gluconate"}
{"X":49466,"RHEA_ID":51286,"compounds":"(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate => (11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate"}
{"X":49467,"RHEA_ID":47916,"compounds":"ATP + N-(hexanoyl)-4-hydroxysphinganine = ADP + H(+) + N-(hexanoyl)-4-hydroxysphinganine-1-phosphate"}
{"X":49468,"RHEA_ID":61565,"compounds":"a tetracycline + H(+) + NADPH + O2 => a (1S,10aS)-3-(CONH2)-1-(Me2N)-3,3a,4,6-(HO)4-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracene + CO + H2O + NADP(+)"}
{"X":49469,"RHEA_ID":47918,"compounds":"ADP + H(+) + N-(hexanoyl)-4-hydroxysphinganine-1-phosphate => ATP + N-(hexanoyl)-4-hydroxysphinganine"}
{"X":49470,"RHEA_ID":47919,"compounds":"ATP + N-(hexanoyl)-4-hydroxysphinganine <=> ADP + H(+) + N-(hexanoyl)-4-hydroxysphinganine-1-phosphate"}
{"X":49471,"RHEA_ID":47920,"compounds":"ganglioside GM2 (d18:1(4E)/18:0) + H2O = ganglioside GA2 (d18:1(4E)/18:0) + N-acetylneuraminate"}
{"X":49472,"RHEA_ID":61569,"compounds":"an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O => an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + D-galactosamine"}
{"X":49473,"RHEA_ID":47922,"compounds":"ganglioside GA2 (d18:1(4E)/18:0) + N-acetylneuraminate => ganglioside GM2 (d18:1(4E)/18:0) + H2O"}
{"X":49474,"RHEA_ID":47923,"compounds":"ganglioside GM2 (d18:1(4E)/18:0) + H2O <=> ganglioside GA2 (d18:1(4E)/18:0) + N-acetylneuraminate"}
{"X":49475,"RHEA_ID":47924,"DIRECTION":"UN","MASTER_ID":47924,"ec":"4.1.2.58","compounds":"2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate = (S)-3-sulfolactaldehyde + pyruvate"}
{"X":49476,"RHEA_ID":61573,"compounds":"(11Z,14Z)-eicosadienoate + O2 => (15S)-hydroperoxy-(11Z,13E)-eicosadienoate"}
{"X":49477,"RHEA_ID":47926,"compounds":"(S)-3-sulfolactaldehyde + pyruvate => 2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate"}
{"X":49478,"RHEA_ID":47927,"compounds":"2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate <=> (S)-3-sulfolactaldehyde + pyruvate"}
{"X":49479,"RHEA_ID":54617,"compounds":"2-oxoglutarate + heptadecanoyl-CoA + O2 => 2-hydroxyheptadecanoyl-CoA + CO2 + succinate"}
{"X":49480,"RHEA_ID":51300,"compounds":"(9Z)-octadecenoate + L-phenylalanine = H2O + N-(9Z-octadecenoyl)-L-phenylalanine"}
{"X":49481,"RHEA_ID":47930,"compounds":"(S)-3-sulfolactate + 2 H(+) + NADPH => (S)-3-sulfolactaldehyde + H2O + NADP(+)"}
{"X":49482,"RHEA_ID":57964,"DIRECTION":"UN","MASTER_ID":57964,"ec":"1.14.14.168","compounds":"germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":49483,"RHEA_ID":47932,"DIRECTION":"UN","MASTER_ID":47932,"ec":"1.2.1.97","compounds":"(S)-3-sulfolactaldehyde + H2O + NAD(+) = (R)-3-sulfolactate + 2 H(+) + NADH"}
{"X":49484,"RHEA_ID":57965,"compounds":"germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":49485,"RHEA_ID":47934,"compounds":"(R)-3-sulfolactate + 2 H(+) + NADH => (S)-3-sulfolactaldehyde + H2O + NAD(+)"}
{"X":49486,"RHEA_ID":57968,"DIRECTION":"UN","MASTER_ID":57968,"ec":"1.14.14.170","compounds":"germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = 8-epi-inunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":49487,"RHEA_ID":61584,"compounds":"cytidine(72) in tRNA(Cys) + S-adenosyl-L-methionine = 5-methylcytidine(72) in tRNA(Cys) + H(+) + S-adenosyl-L-homocysteine"}
{"X":49488,"RHEA_ID":61585,"compounds":"cytidine(72) in tRNA(Cys) + S-adenosyl-L-methionine => 5-methylcytidine(72) in tRNA(Cys) + H(+) + S-adenosyl-L-homocysteine"}
{"X":49489,"RHEA_ID":47938,"compounds":"4-hydroxybenzoate + 2 H(+) + NADPH => 4-hydroxybenzaldehyde + H2O + NADP(+)"}
{"X":49490,"RHEA_ID":57972,"DIRECTION":"UN","MASTER_ID":57972,"ec":"1.14.14.169","compounds":"8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = eupatolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":49491,"RHEA_ID":61588,"DIRECTION":"UN","MASTER_ID":61588,"ec":"2.7.1.230","compounds":"amicoumacin A + ATP = ADP + amicoumacin A 2-phosphate + H(+)"}
{"X":49492,"RHEA_ID":57974,"compounds":"eupatolide + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":49493,"RHEA_ID":47942,"compounds":"ganglioside GM3 (d18:1(4E)) + N-acetyl-beta-D-galactosamine => ganglioside GM2 (d18:1(4E)) + H2O"}
{"X":49494,"RHEA_ID":47943,"compounds":"ganglioside GM2 (d18:1(4E)) + H2O <=> ganglioside GM3 (d18:1(4E)) + N-acetyl-beta-D-galactosamine"}
{"X":49495,"RHEA_ID":47944,"DIRECTION":"UN","MASTER_ID":47944,"ec":"3.6.1.68","compounds":"(2E)-geranyl diphosphate + H2O = (2E)-geranyl phosphate + H(+) + phosphate"}
{"X":49496,"RHEA_ID":61597,"compounds":"[DsbD protein]-dithiol + [thioredoxin]-disulfide => [DsbD protein]-disulfide + [thioredoxin]-dithiol"}
{"X":49497,"RHEA_ID":47946,"compounds":"(2E)-geranyl phosphate + H(+) + phosphate => (2E)-geranyl diphosphate + H2O"}
{"X":49498,"RHEA_ID":57980,"DIRECTION":"UN","MASTER_ID":57980,"ec":"2.4.1.363","compounds":"(20S)-protopanaxatriol + UDP-alpha-D-glucose = (20S)-ginsenoside F1 + H(+) + UDP"}
{"X":49499,"RHEA_ID":47948,"DIRECTION":"UN","MASTER_ID":47948,"ec":"3.1.3.100","compounds":"H2O + thiamine phosphate = phosphate + thiamine"}
{"X":49500,"RHEA_ID":57982,"compounds":"(20S)-ginsenoside F1 + H(+) + UDP => (20S)-protopanaxatriol + UDP-alpha-D-glucose"}
{"X":49501,"RHEA_ID":47950,"compounds":"phosphate + thiamine => H2O + thiamine phosphate"}
{"X":49502,"RHEA_ID":57984,"DIRECTION":"UN","MASTER_ID":57984,"ec":"2.4.1.363","compounds":"(20S)-ginsenoside Rg3 + UDP-alpha-D-glucose = (20S)-ginsenoside Rd + H(+) + UDP"}
{"X":49503,"RHEA_ID":47952,"DIRECTION":"UN","MASTER_ID":47952,"ec":"3.5.1.119","compounds":"[prokaryotic ubiquitin-like protein]-C-terminal-L-glutamine + H2O = [prokaryotic ubiquitin-like protein]-C-terminal-L-glutamate + NH4(+)"}
{"X":49504,"RHEA_ID":57986,"compounds":"(20S)-ginsenoside Rd + H(+) + UDP => (20S)-ginsenoside Rg3 + UDP-alpha-D-glucose"}
{"X":49505,"RHEA_ID":47954,"compounds":"[prokaryotic ubiquitin-like protein]-C-terminal-L-glutamate + NH4(+) => [prokaryotic ubiquitin-like protein]-C-terminal-L-glutamine + H2O"}
{"X":49506,"RHEA_ID":47956,"DIRECTION":"UN","MASTER_ID":47956,"ec":"3.7.1.23","compounds":"3-maleylpyruvate + H2O = H(+) + maleate + pyruvate"}
{"X":49507,"RHEA_ID":51332,"compounds":"(8Z,11Z,14Z)-eicosatrienoate + O2 = 11-hydroperoxy-(8Z,12E,14Z)-eicosatrienoate"}
{"X":49508,"RHEA_ID":47958,"compounds":"H(+) + maleate + pyruvate => 3-maleylpyruvate + H2O"}
{"X":49509,"RHEA_ID":57992,"DIRECTION":"UN","MASTER_ID":57992,"ec":"2.4.1.364","compounds":"(20S)-ginsenoside C-K + UDP-alpha-D-glucose = (20S)-ginsenoside F2 + H(+) + UDP"}
{"X":49510,"RHEA_ID":61612,"DIRECTION":"UN","MASTER_ID":61612,"ec":"1.14.11.70","compounds":"2-oxoglutarate + 7-deoxycylindrospermopsin + O2 = 7-epi-cylindrospermopsin + CO2 + succinate"}
{"X":49511,"RHEA_ID":61613,"DIRECTION":"LR","MASTER_ID":61612,"metacyc":"RXN-20454","compounds":"2-oxoglutarate + 7-deoxycylindrospermopsin + O2 => 7-epi-cylindrospermopsin + CO2 + succinate"}
{"X":49512,"RHEA_ID":47961,"DIRECTION":"LR","MASTER_ID":47960,"metacyc":"RXN-17133","compounds":"H2O + N(tele)-phospho-L-histidyl-[protein] => L-histidyl-[protein] + phosphate"}
{"X":49513,"RHEA_ID":47962,"compounds":"L-histidyl-[protein] + phosphate => H2O + N(tele)-phospho-L-histidyl-[protein]"}
{"X":49514,"RHEA_ID":61620,"DIRECTION":"UN","MASTER_ID":61620,"ec":"2.4.1.374","compounds":"[(1->2)-beta-D-mannosyl](n) + GDP-alpha-D-mannose = [(1->2)-beta-D-mannosyl](n+1) + GDP + H(+)"}
{"X":49515,"RHEA_ID":49071,"compounds":"25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (1S)-1,25-dihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin]"}
{"X":49516,"RHEA_ID":47965,"DIRECTION":"LR","MASTER_ID":47964,"metacyc":"RXN-17131","compounds":"H2O + N(pros)-phospho-L-histidyl-[protein] => L-histidyl-[protein] + phosphate"}
{"X":49517,"RHEA_ID":47965,"DIRECTION":"LR","MASTER_ID":47964,"metacyc":"RXN-17133","compounds":"H2O + N(pros)-phospho-L-histidyl-[protein] => L-histidyl-[protein] + phosphate"}
{"X":49518,"RHEA_ID":61624,"compounds":"2-oxoglutarate + cadaverine = 5-aminopentanal + L-glutamate"}
{"X":49519,"RHEA_ID":61625,"DIRECTION":"LR","MASTER_ID":61624,"ecocyc":"RXN0-7317","metacyc":"RXN0-7317","compounds":"2-oxoglutarate + cadaverine => 5-aminopentanal + L-glutamate"}
{"X":49520,"RHEA_ID":47968,"compounds":"ganglioside GM2 + H2O = ganglioside GM3 + N-acetyl-beta-D-galactosamine"}
{"X":49521,"RHEA_ID":47969,"compounds":"ganglioside GM2 + H2O => ganglioside GM3 + N-acetyl-beta-D-galactosamine"}
{"X":49522,"RHEA_ID":47970,"compounds":"ganglioside GM3 + N-acetyl-beta-D-galactosamine => ganglioside GM2 + H2O"}
{"X":49523,"RHEA_ID":58005,"DIRECTION":"LR","MASTER_ID":58004,"metacyc":"RXN-19695","compounds":"(20S)-ginsenoside F2 + UDP-alpha-D-glucose => (20S)-ginsenoside Rd + H(+) + UDP"}
{"X":49524,"RHEA_ID":47972,"DIRECTION":"UN","MASTER_ID":47972,"ec":"4.2.1.159","compounds":"dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H2O"}
{"X":49525,"RHEA_ID":47973,"compounds":"dTDP-4-dehydro-6-deoxy-alpha-D-glucose => dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H2O"}
{"X":49526,"RHEA_ID":61632,"compounds":"5-aminopentanal + H2O + NAD(+) = 5-aminopentanoate + 2 H(+) + NADH"}
{"X":49527,"RHEA_ID":59122,"compounds":"2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + CO2 => 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + H(+)"}
{"X":49528,"RHEA_ID":47976,"compounds":"dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose + H2O"}
{"X":49529,"RHEA_ID":47977,"DIRECTION":"LR","MASTER_ID":47976,"metacyc":"RXN-12404","compounds":"dTDP-4-dehydro-6-deoxy-alpha-D-glucose => dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose + H2O"}
{"X":49530,"RHEA_ID":47978,"compounds":"dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose + H2O => dTDP-4-dehydro-6-deoxy-alpha-D-glucose"}
{"X":49531,"RHEA_ID":58012,"compounds":"cyclic tetraadenylate = 2 5'-hydroxy-diadenylate 2',3'-cylic phosphate"}
{"X":49532,"RHEA_ID":47980,"compounds":"dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose = dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose"}
{"X":49533,"RHEA_ID":47981,"DIRECTION":"LR","MASTER_ID":47980,"metacyc":"RXN-12943","compounds":"dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose => dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose"}
{"X":49534,"RHEA_ID":47982,"compounds":"dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose => dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose"}
{"X":49535,"RHEA_ID":61645,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + N(omega)-hydroxy-L-arginine => 2 [Fe(III)-cytochrome b5] + H2O + L-arginine"}
{"X":49536,"RHEA_ID":47984,"DIRECTION":"UN","MASTER_ID":47984,"ec":"4.2.3.156","compounds":"H2O + presqualene diphosphate = diphosphate + hydroxysqualene"}
{"X":49537,"RHEA_ID":47985,"DIRECTION":"LR","MASTER_ID":47984,"metacyc":"RXN-17129","compounds":"H2O + presqualene diphosphate => diphosphate + hydroxysqualene"}
{"X":49538,"RHEA_ID":47986,"compounds":"diphosphate + hydroxysqualene => H2O + presqualene diphosphate"}
{"X":49539,"RHEA_ID":58021,"compounds":"6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) => eupatolide + H2O"}
{"X":49540,"RHEA_ID":61658,"compounds":"(2E,6E)-farnesyl phosphate + ADP + H(+) => (2E,6E)-farnesol + ATP"}
{"X":49541,"RHEA_ID":58023,"compounds":"6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) <=> eupatolide + H2O"}
{"X":49542,"RHEA_ID":47990,"compounds":"3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH => 2-dehydro-3-deoxy-L-galactonate + NAD(+)"}
{"X":49543,"RHEA_ID":51368,"compounds":"glycine + octadecanoyl-CoA = CoA + H(+) + N-octadecanoylglycine"}
{"X":49544,"RHEA_ID":47992,"DIRECTION":"UN","MASTER_ID":47992,"ec":"7.1.1.1","compounds":"H(+)(in) + NAD(+) + NADPH = H(+)(out) + NADH + NADP(+)"}
{"X":49545,"RHEA_ID":58027,"compounds":"oleanolate + UDP-alpha-D-glucose <=> H(+) + oleanolate 3-O-beta-D-glucoside + UDP"}
{"X":49546,"RHEA_ID":47994,"DIRECTION":"RL","MASTER_ID":47992,"ecocyc":"TRANS-RXN0-277","metacyc":"TRANS-RXN0-277","compounds":"H(+)(out) + NADH + NADP(+) => H(+)(in) + NAD(+) + NADPH"}
{"X":49547,"RHEA_ID":58029,"compounds":"5 (S)-methylmalonyl-CoA + a medium-chain fatty acyl-CoA + 32 H(+) + 5 malonyl-CoA + 22 NADPH => a mycoketide-CoA + 10 CO2 + 10 CoA + 11 H2O + 22 NADP(+)"}
{"X":49548,"RHEA_ID":47996,"DIRECTION":"UN","MASTER_ID":47996,"ec":"1.6.3.5","compounds":"1,6-dihydro-beta-NAD + H(+) + O2 = H2O2 + NAD(+)"}
{"X":49549,"RHEA_ID":58031,"compounds":"5 (S)-methylmalonyl-CoA + a medium-chain fatty acyl-CoA + 32 H(+) + 5 malonyl-CoA + 22 NADPH <=> a mycoketide-CoA + 10 CO2 + 10 CoA + 11 H2O + 22 NADP(+)"}
{"X":49550,"RHEA_ID":47998,"compounds":"H2O2 + NAD(+) => 1,6-dihydro-beta-NAD + H(+) + O2"}
{"X":49551,"RHEA_ID":58033,"DIRECTION":"LR","MASTER_ID":58032,"metacyc":"RXN-20049","compounds":"germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => 8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":49552,"RHEA_ID":51377,"compounds":"dopamine + hexadecanoyl-CoA => CoA + H(+) + N-hexadecanoyl-dopamine"}
{"X":49553,"RHEA_ID":58035,"compounds":"germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":49554,"RHEA_ID":48002,"compounds":"H2O2 + NADP(+) => 1,6-dihydro-beta-NADP + H(+) + O2"}
{"X":49555,"RHEA_ID":48003,"DIRECTION":"BI","MASTER_ID":48000,"metacyc":"RXN-16773","compounds":"1,6-dihydro-beta-NADP + H(+) + O2 <=> H2O2 + NADP(+)"}
{"X":49556,"RHEA_ID":58038,"compounds":"8-epi-inunolide + H2O => 8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+)"}
{"X":49557,"RHEA_ID":58039,"compounds":"8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) <=> 8-epi-inunolide + H2O"}
{"X":49558,"RHEA_ID":61716,"DIRECTION":"UN","MASTER_ID":61716,"ec":"7.5.2.9","compounds":"ATP + D-galactofuranose(out) + H2O = ADP + D-galactofuranose(in) + H(+) + phosphate"}
{"X":49559,"RHEA_ID":61717,"DIRECTION":"LR","MASTER_ID":61716,"metacyc":"TRANS-RXN-333","compounds":"ATP + D-galactofuranose(out) + H2O => ADP + D-galactofuranose(in) + H(+) + phosphate"}
{"X":49560,"RHEA_ID":58042,"compounds":"(9Z,12Z,15Z)-octadecatrienoate + glycerol + H(+) => 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + H2O"}
{"X":49561,"RHEA_ID":58043,"compounds":"1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + H2O <=> (9Z,12Z,15Z)-octadecatrienoate + glycerol + H(+)"}
{"X":49562,"RHEA_ID":48010,"compounds":"2,5-dihydroxybenzoyl-CoA + H2O + NAD(+) => 2-hydroxybenzoyl-CoA + H(+) + NADH + O2"}
{"X":49563,"RHEA_ID":58045,"DIRECTION":"LR","MASTER_ID":58044,"metacyc":"RXN-17177","compounds":"a long-chain fatty acyl-CoA + alpha,alpha-trehalose => 2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + CoA"}
{"X":49564,"RHEA_ID":58046,"compounds":"2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + CoA => a long-chain fatty acyl-CoA + alpha,alpha-trehalose"}
{"X":49565,"RHEA_ID":51390,"compounds":"CoA + H(+) + N-acetyl-dopamine => acetyl-CoA + dopamine"}
{"X":49566,"RHEA_ID":61724,"compounds":"a D-glucoside + NAD(+) = a 3-dehydro-D-glucoside + H(+) + NADH"}
{"X":49567,"RHEA_ID":58049,"DIRECTION":"LR","MASTER_ID":58048,"metacyc":"RXN-17326","compounds":"2-O-sulfo-alpha,alpha-trehalose + octadecanoyl-CoA => 2-O-sulfo-2'-O-octadecanoyl-alpha,alpha-trehalose + CoA"}
{"X":49568,"RHEA_ID":58050,"compounds":"2-O-sulfo-2'-O-octadecanoyl-alpha,alpha-trehalose + CoA => 2-O-sulfo-alpha,alpha-trehalose + octadecanoyl-CoA"}
{"X":49569,"RHEA_ID":58051,"compounds":"2-O-sulfo-alpha,alpha-trehalose + octadecanoyl-CoA <=> 2-O-sulfo-2'-O-octadecanoyl-alpha,alpha-trehalose + CoA"}
{"X":49570,"RHEA_ID":48018,"compounds":"2-hydroxy-5-methylquinone + H(+) + H2O + NAD(+) + nitrite => 4-methyl-5-nitrocatechol + NADH + O2"}
{"X":49571,"RHEA_ID":58053,"DIRECTION":"LR","MASTER_ID":58052,"metacyc":"RXN-17962","compounds":"(2-aminoethyl)phosphonate + acetyl-CoA => (2-acetamidoethyl)phosphonate + CoA + H(+)"}
{"X":49572,"RHEA_ID":58054,"compounds":"(2-acetamidoethyl)phosphonate + CoA + H(+) => (2-aminoethyl)phosphonate + acetyl-CoA"}
{"X":49573,"RHEA_ID":58055,"compounds":"(2-aminoethyl)phosphonate + acetyl-CoA <=> (2-acetamidoethyl)phosphonate + CoA + H(+)"}
{"X":49574,"RHEA_ID":48022,"compounds":"beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + D-galactose => globoside Gb3Cer + H2O"}
{"X":49575,"RHEA_ID":48023,"compounds":"globoside Gb3Cer + H2O <=> beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + D-galactose"}
{"X":49576,"RHEA_ID":58058,"compounds":"2-sulfinoacetaldehyde + L-alanine => hypotaurine + pyruvate"}
{"X":49577,"RHEA_ID":58059,"DIRECTION":"BI","MASTER_ID":58056,"metacyc":"RXN-14907","compounds":"hypotaurine + pyruvate <=> 2-sulfinoacetaldehyde + L-alanine"}
{"X":49578,"RHEA_ID":61736,"compounds":"steviolmonoside + UDP-alpha-D-glucose = rubusoside + UDP"}
{"X":49579,"RHEA_ID":48027,"compounds":"1,2,3-tripropanoylglycerol + H2O <=> dipropanoylglycerol + H(+) + propanoate"}
{"X":49580,"RHEA_ID":48028,"compounds":"H2O + triacetin = acetate + diacetylglycerol + H(+)"}
{"X":49581,"RHEA_ID":48029,"compounds":"H2O + triacetin => acetate + diacetylglycerol + H(+)"}
{"X":49582,"RHEA_ID":54725,"DIRECTION":"LR","MASTER_ID":54724,"metacyc":"RXN-13225","compounds":"N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine => 3 H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine"}
{"X":49583,"RHEA_ID":48031,"compounds":"H2O + triacetin <=> acetate + diacetylglycerol + H(+)"}
{"X":49584,"RHEA_ID":48032,"compounds":"(2S)-2-methylbutanoyl-CoA + FAD + H(+) = (2E)-2-methylbutenoyl-CoA + FADH2"}
{"X":49585,"RHEA_ID":48033,"compounds":"(2S)-2-methylbutanoyl-CoA + FAD + H(+) => (2E)-2-methylbutenoyl-CoA + FADH2"}
{"X":49586,"RHEA_ID":48034,"compounds":"(2E)-2-methylbutenoyl-CoA + FADH2 => (2S)-2-methylbutanoyl-CoA + FAD + H(+)"}
{"X":49587,"RHEA_ID":61745,"DIRECTION":"LR","MASTER_ID":61744,"metacyc":"RXN-13514","compounds":"steviolbioside + UDP-alpha-D-glucose => stevioside + UDP"}
{"X":49588,"RHEA_ID":58070,"compounds":"acetaldehyde + vanillin => O2 + trans-isoeugenol"}
{"X":49589,"RHEA_ID":48037,"compounds":"globoside Gb4Cer (d18:1(4E)) + H2O => globoside Gb3Cer (d18:1(4E)) + N-acetyl-beta-D-galactosamine"}
{"X":49590,"RHEA_ID":48038,"compounds":"globoside Gb3Cer (d18:1(4E)) + N-acetyl-beta-D-galactosamine => globoside Gb4Cer (d18:1(4E)) + H2O"}
{"X":49591,"RHEA_ID":48039,"compounds":"globoside Gb4Cer (d18:1(4E)) + H2O <=> globoside Gb3Cer (d18:1(4E)) + N-acetyl-beta-D-galactosamine"}
{"X":49592,"RHEA_ID":58074,"compounds":"a jasmonate + NADP(+) => a 4,5-didehydrojasmonate + H(+) + NADPH"}
{"X":49593,"RHEA_ID":48041,"compounds":"globoside Gb4Cer + H2O => globoside Gb3Cer + N-acetyl-beta-D-galactosamine"}
{"X":49594,"RHEA_ID":48042,"compounds":"globoside Gb3Cer + N-acetyl-beta-D-galactosamine => globoside Gb4Cer + H2O"}
{"X":49595,"RHEA_ID":48043,"compounds":"globoside Gb4Cer + H2O <=> globoside Gb3Cer + N-acetyl-beta-D-galactosamine"}
{"X":49596,"RHEA_ID":48044,"compounds":"ganglioside GM1 (d18:1(4E)/18:0) + H2O = D-galactose + ganglioside GM2 (d18:1(4E)/18:0)"}
{"X":49597,"RHEA_ID":58079,"compounds":"1-(11Z-eicosenoyl)-glycerol + H2O <=> (11Z)-eicosenoate + glycerol + H(+)"}
{"X":49598,"RHEA_ID":61756,"compounds":"stevioside + UDP-alpha-D-glucose = H(+) + rebaudioside A + UDP"}
{"X":49599,"RHEA_ID":48047,"compounds":"ganglioside GM1 (d18:1(4E)/18:0) + H2O <=> D-galactose + ganglioside GM2 (d18:1(4E)/18:0)"}
{"X":49600,"RHEA_ID":48048,"compounds":"ganglioside GM1 (d18:1(4E)) + H2O = D-galactose + ganglioside GM2 (d18:1(4E))"}
{"X":49601,"RHEA_ID":58083,"compounds":"1-docosanoylglycerol + H2O <=> docosanoate + glycerol + H(+)"}
{"X":49602,"RHEA_ID":48050,"compounds":"D-galactose + ganglioside GM2 (d18:1(4E)) => ganglioside GM1 (d18:1(4E)) + H2O"}
{"X":49603,"RHEA_ID":48051,"compounds":"ganglioside GM1 (d18:1(4E)) + H2O <=> D-galactose + ganglioside GM2 (d18:1(4E))"}
{"X":49604,"RHEA_ID":58086,"compounds":"(13Z)-docosenoate + glycerol + H(+) => 1-(13Z-docosenoyl)-glycerol + H2O"}
{"X":49605,"RHEA_ID":58087,"compounds":"1-(13Z-docosenoyl)-glycerol + H2O <=> (13Z)-docosenoate + glycerol + H(+)"}
{"X":49606,"RHEA_ID":48054,"compounds":"n adenosine 3',5'-bisphosphate + dermatan 4'-sulfate + n H(+) => n 3'-phosphoadenylyl sulfate + dermatan"}
{"X":49607,"RHEA_ID":58089,"compounds":"1-(7Z,10Z,13Z,16Z-docosatetraenoyl)-glycerol + H2O => (7Z,10Z,13Z,16Z)-docosatetraenoate + glycerol + H(+)"}
{"X":49608,"RHEA_ID":58090,"compounds":"(7Z,10Z,13Z,16Z)-docosatetraenoate + glycerol + H(+) => 1-(7Z,10Z,13Z,16Z-docosatetraenoyl)-glycerol + H2O"}
{"X":49609,"RHEA_ID":58091,"compounds":"1-(7Z,10Z,13Z,16Z-docosatetraenoyl)-glycerol + H2O <=> (7Z,10Z,13Z,16Z)-docosatetraenoate + glycerol + H(+)"}
{"X":49610,"RHEA_ID":48058,"compounds":"beta-D-glucosylceramide + D-galactose => beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O"}
{"X":49611,"RHEA_ID":58093,"compounds":"1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + glycerol + H(+)"}
{"X":49612,"RHEA_ID":58094,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + glycerol + H(+) => 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O"}
{"X":49613,"RHEA_ID":58095,"compounds":"1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + glycerol + H(+)"}
{"X":49614,"RHEA_ID":61772,"compounds":"rebaudioside E + UDP-alpha-D-glucose = H(+) + rebaudioside D + UDP"}
{"X":49615,"RHEA_ID":58096,"compounds":"1-tetracosanoylglycerol + H2O = glycerol + H(+) + tetracosanoate"}
{"X":49616,"RHEA_ID":48064,"compounds":"ganglioside GD1b (d18:1(4E)) + H2O = ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate"}
{"X":49617,"RHEA_ID":58099,"compounds":"1-tetracosanoylglycerol + H2O <=> glycerol + H(+) + tetracosanoate"}
{"X":49618,"RHEA_ID":51443,"compounds":"(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (11S)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate"}
{"X":49619,"RHEA_ID":48067,"compounds":"ganglioside GD1b (d18:1(4E)) + H2O <=> ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate"}
{"X":49620,"RHEA_ID":58102,"compounds":"(15Z)-tetracosenoate + glycerol + H(+) => 1-(15Z-tetracosenoyl)-glycerol + H2O"}
{"X":49621,"RHEA_ID":58103,"compounds":"1-(15Z-tetracosenoyl)-glycerol + H2O <=> (15Z)-tetracosenoate + glycerol + H(+)"}
{"X":49622,"RHEA_ID":48070,"compounds":"ganglioside GA2 (d18:1(4E)) + N-acetylneuraminate => ganglioside GM2 (d18:1(4E)) + H2O"}
{"X":49623,"RHEA_ID":48071,"compounds":"ganglioside GM2 (d18:1(4E)) + H2O <=> ganglioside GA2 (d18:1(4E)) + N-acetylneuraminate"}
{"X":49624,"RHEA_ID":51449,"compounds":"chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase] => alpha-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":49625,"RHEA_ID":58107,"compounds":"(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O <=> (14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate"}
{"X":49626,"RHEA_ID":48074,"compounds":"ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate => ganglioside GM1 (d18:1(4E)) + H2O"}
{"X":49627,"RHEA_ID":48075,"compounds":"ganglioside GM1 (d18:1(4E)) + H2O <=> ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate"}
{"X":49628,"RHEA_ID":61786,"compounds":"keto-L-fructose => L-allulose"}
{"X":49629,"RHEA_ID":58111,"compounds":"H2O + N(6)-acetyl-L-lysyl-[protein] <=> acetate + L-lysyl-[protein]"}
{"X":49630,"RHEA_ID":48078,"compounds":"4-(hydroxylamino)-N,N-dimethylaniline + an aldehyde => a primary alcohol + N,N-dimethyl-4-nitrosoaniline"}
{"X":49631,"RHEA_ID":48079,"compounds":"a primary alcohol + N,N-dimethyl-4-nitrosoaniline <=> 4-(hydroxylamino)-N,N-dimethylaniline + an aldehyde"}
{"X":49632,"RHEA_ID":58114,"compounds":"acetate + ADP-D-ribose + H(+) => 1''-O-acetyl-ADP-alpha-D-ribose + H2O"}
{"X":49633,"RHEA_ID":48081,"DIRECTION":"LR","MASTER_ID":48080,"metacyc":"RXN-16786","compounds":"abietatriene + H(+) + NADPH + O2 => ferruginol + H2O + NADP(+)"}
{"X":49634,"RHEA_ID":48082,"compounds":"ferruginol + H2O + NADP(+) => abietatriene + H(+) + NADPH + O2"}
{"X":49635,"RHEA_ID":58117,"compounds":"L-seryl-[EGF-like domain protein] + UDP-alpha-D-glucose => 3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP"}
{"X":49636,"RHEA_ID":58118,"compounds":"3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP => L-seryl-[EGF-like domain protein] + UDP-alpha-D-glucose"}
{"X":49637,"RHEA_ID":48097,"compounds":"L-arginyl-[protein] + 2 S-adenosyl-L-methionine => 2 H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine"}
{"X":49638,"RHEA_ID":48098,"compounds":"2 H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine => L-arginyl-[protein] + 2 S-adenosyl-L-methionine"}
{"X":49639,"RHEA_ID":54782,"compounds":"[LarE protein]-dehydroalanine + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide => [LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine"}
{"X":49640,"RHEA_ID":58122,"compounds":"3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate => ATP + L-seryl-[protein]"}
{"X":49641,"RHEA_ID":48101,"DIRECTION":"LR","MASTER_ID":48100,"metacyc":"RXN-16889","compounds":"L-arginyl-[protein] + S-adenosyl-L-methionine => H(+) + N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":49642,"RHEA_ID":48102,"compounds":"H(+) + N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine => L-arginyl-[protein] + S-adenosyl-L-methionine"}
{"X":49643,"RHEA_ID":54786,"DIRECTION":"RL","MASTER_ID":54784,"metacyc":"RXN-19051","compounds":"Ni(2+) + pyridinium-3,5-bisthiocarboxylate mononucleotide => Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide"}
{"X":49644,"RHEA_ID":58126,"compounds":"H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + polyneuridine aldehyde => (19S)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":49645,"RHEA_ID":58127,"compounds":"(19S)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + polyneuridine aldehyde"}
{"X":49646,"RHEA_ID":48106,"compounds":"H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine => N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine"}
{"X":49647,"RHEA_ID":61829,"DIRECTION":"LR","MASTER_ID":61828,"metacyc":"RXN-12126","compounds":"stigmasterol + UDP-alpha-D-glucose => H(+) + stigmasteryl 3-beta-D-glucoside + UDP"}
{"X":49648,"RHEA_ID":58130,"compounds":"AH2 + alstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => A + O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine"}
{"X":49649,"RHEA_ID":48109,"compounds":"L-arginyl-[protein] + 2 S-adenosyl-L-methionine => 2 H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine"}
{"X":49650,"RHEA_ID":48110,"compounds":"2 H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine => L-arginyl-[protein] + 2 S-adenosyl-L-methionine"}
{"X":49651,"RHEA_ID":61833,"DIRECTION":"LR","MASTER_ID":61832,"metacyc":"RXN-12128","compounds":"(24R)-ethylcholest-5-en-3beta-ol + UDP-alpha-D-glucose => H(+) + sitosteryl 3-beta-D-glucoside + UDP"}
{"X":49652,"RHEA_ID":58134,"compounds":"AH2 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + serpentine => A + ajmalicine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":49653,"RHEA_ID":48113,"compounds":"N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine => H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":49654,"RHEA_ID":48114,"compounds":"H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine => N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine"}
{"X":49655,"RHEA_ID":61837,"DIRECTION":"LR","MASTER_ID":61836,"metacyc":"RXN-16975","compounds":"ergosterol + UDP-alpha-D-glucose => ergosteryl 3-beta-D-glucoside + H(+) + UDP"}
{"X":49656,"RHEA_ID":58138,"compounds":"acetyl-AMP + diphosphate => acetate + ATP + H(+)"}
{"X":49657,"RHEA_ID":48117,"compounds":"L-arginyl-[protein] + S-adenosyl-L-methionine => H(+) + N(5)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":49658,"RHEA_ID":58140,"compounds":"acetyl-AMP + cytidine(34) in elongator tRNA(Met) = AMP + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met)"}
{"X":49659,"RHEA_ID":61841,"DIRECTION":"LR","MASTER_ID":61840,"metacyc":"RXN-12125","compounds":"brassicasterol + UDP-alpha-D-glucose => brassicasterol 3-beta-D-glucoside + H(+) + UDP"}
{"X":49660,"RHEA_ID":58142,"compounds":"AMP + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) => acetyl-AMP + cytidine(34) in elongator tRNA(Met)"}
{"X":49661,"RHEA_ID":48121,"compounds":"ganglioside GD3 + H2O => ganglioside GM3 + N-acetylneuraminate"}
{"X":49662,"RHEA_ID":48122,"compounds":"ganglioside GM3 + N-acetylneuraminate => ganglioside GD3 + H2O"}
{"X":49663,"RHEA_ID":58145,"compounds":"acetate + ATP + cytidine(34) in elongator tRNA(Met) => AMP + diphosphate + N(4)-acetylcytidine(34) in elongator tRNA(Met)"}
{"X":49664,"RHEA_ID":58146,"compounds":"AMP + diphosphate + N(4)-acetylcytidine(34) in elongator tRNA(Met) => acetate + ATP + cytidine(34) in elongator tRNA(Met)"}
{"X":49665,"RHEA_ID":48125,"compounds":"ganglioside GD3 (d18:1(4E)) + H2O => ganglioside GM3 (d18:1(4E)) + N-acetylneuraminate"}
{"X":49666,"RHEA_ID":48126,"compounds":"ganglioside GM3 (d18:1(4E)) + N-acetylneuraminate => ganglioside GD3 (d18:1(4E)) + H2O"}
{"X":49667,"RHEA_ID":48127,"compounds":"ganglioside GD3 (d18:1(4E)) + H2O <=> ganglioside GM3 (d18:1(4E)) + N-acetylneuraminate"}
{"X":49668,"RHEA_ID":48128,"compounds":"(2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-farnesyl phosphate + H(+) + phosphate"}
{"X":49669,"RHEA_ID":48129,"compounds":"(2E,6E)-farnesyl diphosphate + H2O => (2E,6E)-farnesyl phosphate + H(+) + phosphate"}
{"X":49670,"RHEA_ID":58152,"compounds":"H2O + NAD(+) + phosphonoacetaldehyde = 2 H(+) + NADH + phosphonoacetate"}
{"X":49671,"RHEA_ID":48131,"DIRECTION":"BI","MASTER_ID":48128,"ecocyc":"RXN-11776","metacyc":"RXN-11776","compounds":"(2E,6E)-farnesyl diphosphate + H2O <=> (2E,6E)-farnesyl phosphate + H(+) + phosphate"}
{"X":49672,"RHEA_ID":58154,"compounds":"2 H(+) + NADH + phosphonoacetate => H2O + NAD(+) + phosphonoacetaldehyde"}
{"X":49673,"RHEA_ID":48133,"DIRECTION":"LR","MASTER_ID":48132,"metacyc":"RXN-11777","compounds":"(2E,6E)-farnesyl phosphate + H2O => (2E,6E)-farnesol + phosphate"}
{"X":49674,"RHEA_ID":58156,"DIRECTION":"UN","MASTER_ID":58156,"ec":"7.2.2.1","compounds":"ATP + H2O + 4 Na(+)(in) = ADP + H(+) + 4 Na(+)(out) + phosphate"}
{"X":49675,"RHEA_ID":48135,"compounds":"(2E,6E)-farnesyl phosphate + H2O <=> (2E,6E)-farnesol + phosphate"}
{"X":49676,"RHEA_ID":58158,"compounds":"ADP + H(+) + 4 Na(+)(out) + phosphate => ATP + H2O + 4 Na(+)(in)"}
{"X":49677,"RHEA_ID":48137,"compounds":"ganglioside GM3 + H2O => beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetylneuraminate"}
{"X":49678,"RHEA_ID":58160,"DIRECTION":"UN","MASTER_ID":58160,"ec":"4.2.3.196","compounds":"ent-copalyl diphosphate = diphosphate + dolabradiene"}
{"X":49679,"RHEA_ID":48139,"compounds":"ganglioside GM3 + H2O <=> beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetylneuraminate"}
{"X":49680,"RHEA_ID":48140,"DIRECTION":"UN","MASTER_ID":48140,"ec":"1.14.15.17","compounds":"2 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin] = 2 oxidized [2Fe-2S]-[ferredoxin] + red chlorophyll catabolite"}
{"X":49681,"RHEA_ID":48141,"DIRECTION":"LR","MASTER_ID":48140,"metacyc":"RXN-7740","compounds":"2 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin] => 2 oxidized [2Fe-2S]-[ferredoxin] + red chlorophyll catabolite"}
{"X":49682,"RHEA_ID":58164,"DIRECTION":"UN","MASTER_ID":58164,"ec":"4.2.3.197","compounds":"(2E,6E)-farnesyl diphosphate + 2 H2O = 7-epi-ent-eudesmane-5,11-diol + diphosphate"}
{"X":49683,"RHEA_ID":58165,"DIRECTION":"LR","MASTER_ID":58164,"metacyc":"RXN-20043","compounds":"(2E,6E)-farnesyl diphosphate + 2 H2O => 7-epi-ent-eudesmane-5,11-diol + diphosphate"}
{"X":49684,"RHEA_ID":48144,"compounds":"H2O + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-(octadecanoyl)-sphing-4-enine = ganglioside GT1b (d18:1(4E)/18:0) + N-acetylneuraminate"}
{"X":49685,"RHEA_ID":51510,"compounds":"CO2 + succinate + trans-4-hydroxy-L-proline => 2-oxoglutarate + L-proline + O2"}
{"X":49686,"RHEA_ID":48146,"compounds":"ganglioside GT1b (d18:1(4E)/18:0) + N-acetylneuraminate => H2O + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-(octadecanoyl)-sphing-4-enine"}
{"X":49687,"RHEA_ID":48147,"compounds":"H2O + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-(octadecanoyl)-sphing-4-enine <=> ganglioside GT1b (d18:1(4E)/18:0) + N-acetylneuraminate"}
{"X":49688,"RHEA_ID":48148,"compounds":"ganglioside GT1b (d18:1(4E)/18:0) + H2O = ganglioside GD1b(d18:1(4E)/18:0) + N-acetylneuraminate"}
{"X":49689,"RHEA_ID":48149,"compounds":"ganglioside GT1b (d18:1(4E)/18:0) + H2O => ganglioside GD1b(d18:1(4E)/18:0) + N-acetylneuraminate"}
{"X":49690,"RHEA_ID":61872,"compounds":"1-O-methyl-(9Z,12Z)-octadecadienoate + O2 = 1-O-methyl-(9R)-hydroperoxy-(10E,12Z)-octadecadienoate"}
{"X":49691,"RHEA_ID":48151,"compounds":"ganglioside GT1b (d18:1(4E)/18:0) + H2O <=> ganglioside GD1b(d18:1(4E)/18:0) + N-acetylneuraminate"}
{"X":49692,"RHEA_ID":48152,"compounds":"ganglioside GD1b(d18:1(4E)/18:0) + H2O = ganglioside GM1 (d18:1(4E)/18:0) + N-acetylneuraminate"}
{"X":49693,"RHEA_ID":48153,"compounds":"ganglioside GD1b(d18:1(4E)/18:0) + H2O => ganglioside GM1 (d18:1(4E)/18:0) + N-acetylneuraminate"}
{"X":49694,"RHEA_ID":58175,"compounds":"all-trans-geranylgeranyl diphosphate <=> beta-pinacene + diphosphate"}
{"X":49695,"RHEA_ID":48155,"compounds":"ganglioside GD1b(d18:1(4E)/18:0) + H2O <=> ganglioside GM1 (d18:1(4E)/18:0) + N-acetylneuraminate"}
{"X":49696,"RHEA_ID":48156,"compounds":"ganglioside GQ1b (d18:1(4E)) + H2O = ganglioside GT1b (d18:1(4E)) + N-acetylneuraminate"}
{"X":49697,"RHEA_ID":48157,"compounds":"ganglioside GQ1b (d18:1(4E)) + H2O => ganglioside GT1b (d18:1(4E)) + N-acetylneuraminate"}
{"X":49698,"RHEA_ID":58179,"compounds":"2 all-trans-geranylgeranyl diphosphate + H(+) + NADPH <=> all-trans-lycopaoctaene + 2 diphosphate + NADP(+)"}
{"X":49699,"RHEA_ID":48159,"compounds":"ganglioside GQ1b (d18:1(4E)) + H2O <=> ganglioside GT1b (d18:1(4E)) + N-acetylneuraminate"}
{"X":49700,"RHEA_ID":48160,"compounds":"3 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin] = epoxypheophorbide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":49701,"RHEA_ID":48161,"DIRECTION":"LR","MASTER_ID":48160,"metacyc":"RXN-17252","compounds":"3 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin] => epoxypheophorbide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":49702,"RHEA_ID":58183,"compounds":"(1R,2R,3R)-prephytoene diphosphate + H(+) + NADPH <=> all-trans-lycopaoctaene + diphosphate + NADP(+)"}
{"X":49703,"RHEA_ID":58185,"DIRECTION":"LR","MASTER_ID":58184,"metacyc":"RXN-19165","compounds":"H(+) + NADPH + 2 phytyl diphosphate => (14E,18E)-lycopadiene + 2 diphosphate + NADP(+)"}
{"X":49704,"RHEA_ID":48164,"compounds":"epoxypheophorbide a + H2O = H(+) + red chlorophyll catabolite"}
{"X":49705,"RHEA_ID":48165,"DIRECTION":"LR","MASTER_ID":48164,"metacyc":"RXN-17253","compounds":"epoxypheophorbide a + H2O => H(+) + red chlorophyll catabolite"}
{"X":49706,"RHEA_ID":61888,"compounds":"diosgenin + UDP-alpha-D-glucose = diosgenin 3-beta-D-glucoside + H(+) + UDP"}
{"X":49707,"RHEA_ID":58189,"DIRECTION":"LR","MASTER_ID":58188,"metacyc":"RXN-19167","compounds":"all-trans-lycopene + dimethylallyl diphosphate + H2O => dihydroisopentenyldehydrorhodopin + diphosphate"}
{"X":49708,"RHEA_ID":48168,"compounds":"H2O + N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine = N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine + N-acetylneuraminate"}
{"X":49709,"RHEA_ID":48169,"compounds":"H2O + N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine => N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine + N-acetylneuraminate"}
{"X":49710,"RHEA_ID":58192,"DIRECTION":"UN","MASTER_ID":58192,"ec":"2.5.1.150","compounds":"dimethylallyl diphosphate + H2O + isopentenyldehydrorhodopin = dihydrobisanhydrobacterioruberin + diphosphate"}
{"X":49711,"RHEA_ID":48171,"compounds":"H2O + N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine <=> N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine + N-acetylneuraminate"}
{"X":49712,"RHEA_ID":58194,"compounds":"dihydrobisanhydrobacterioruberin + diphosphate => dimethylallyl diphosphate + H2O + isopentenyldehydrorhodopin"}
{"X":49713,"RHEA_ID":48173,"compounds":"ganglioside GM2 + H2O => N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetylneuraminate"}
{"X":49714,"RHEA_ID":58196,"DIRECTION":"UN","MASTER_ID":58196,"ec":"3.5.1.98","compounds":"H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl-[histone]"}
{"X":49715,"RHEA_ID":48175,"compounds":"ganglioside GM2 + H2O <=> N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetylneuraminate"}
{"X":49716,"RHEA_ID":58198,"compounds":"acetate + L-lysyl-[histone] => H2O + N(6)-acetyl-L-lysyl-[histone]"}
{"X":49717,"RHEA_ID":48177,"DIRECTION":"LR","MASTER_ID":48176,"metacyc":"RXN-13615","compounds":"decanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-decenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":49718,"RHEA_ID":58200,"DIRECTION":"UN","MASTER_ID":58200,"ec":"2.6.1.116","compounds":"2-oxoglutarate + 6-aminohexanoate = 6-oxohexanoate + L-glutamate"}
{"X":49719,"RHEA_ID":58201,"compounds":"2-oxoglutarate + 6-aminohexanoate => 6-oxohexanoate + L-glutamate"}
{"X":49720,"RHEA_ID":58202,"compounds":"6-oxohexanoate + L-glutamate => 2-oxoglutarate + 6-aminohexanoate"}
{"X":49721,"RHEA_ID":48181,"compounds":"H(+) + octanoyl-CoA + oxidized [electron-transfer flavoprotein] => (2E)-octenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":49722,"RHEA_ID":48182,"compounds":"(2E)-octenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + octanoyl-CoA + oxidized [electron-transfer flavoprotein]"}
{"X":49723,"RHEA_ID":58205,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine => dihydroalstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":49724,"RHEA_ID":58206,"compounds":"dihydroalstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine"}
{"X":49725,"RHEA_ID":48185,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":49726,"RHEA_ID":58208,"compounds":"A + dihydroalstonine = AH2 + alstonine"}
{"X":49727,"RHEA_ID":48187,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":49728,"RHEA_ID":58210,"compounds":"AH2 + alstonine => A + dihydroalstonine"}
{"X":49729,"RHEA_ID":48189,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,9Z,12Z)-octadecatrienoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":49730,"RHEA_ID":58212,"compounds":"ajmalicine + O2 + reduced [NADPH--hemoprotein reductase] = dihydroserpentine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":49731,"RHEA_ID":58213,"compounds":"ajmalicine + O2 + reduced [NADPH--hemoprotein reductase] => dihydroserpentine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":49732,"RHEA_ID":58214,"compounds":"dihydroserpentine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => ajmalicine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":49733,"RHEA_ID":48193,"compounds":"(9E)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,9E)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":49734,"RHEA_ID":48194,"compounds":"(2E,9E)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein] => (9E)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":49735,"RHEA_ID":48195,"compounds":"(9E)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,9E)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":49736,"RHEA_ID":51561,"compounds":"(S)-bulbocapnine + S-adenosyl-L-methionine => (S)-N-methylbulbocapnine + H(+) + S-adenosyl-L-homocysteine"}
{"X":49737,"RHEA_ID":48197,"compounds":"H(+) + heptadecanoyl-CoA + oxidized [electron-transfer flavoprotein] => reduced [electron-transfer flavoprotein] + trans-2-heptadecenoyl-CoA"}
{"X":49738,"RHEA_ID":48198,"compounds":"reduced [electron-transfer flavoprotein] + trans-2-heptadecenoyl-CoA => H(+) + heptadecanoyl-CoA + oxidized [electron-transfer flavoprotein]"}
{"X":49739,"RHEA_ID":48199,"compounds":"H(+) + heptadecanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> reduced [electron-transfer flavoprotein] + trans-2-heptadecenoyl-CoA"}
{"X":49740,"RHEA_ID":51565,"DIRECTION":"LR","MASTER_ID":51564,"metacyc":"RXN-17644","compounds":"cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => (25S)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":49741,"RHEA_ID":48201,"compounds":"H(+) + oxidized [electron-transfer flavoprotein] + undecanoyl-CoA => reduced [electron-transfer flavoprotein] + trans-2-undecenoyl-CoA"}
{"X":49742,"RHEA_ID":58224,"compounds":"L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide"}
{"X":49743,"RHEA_ID":48203,"compounds":"H(+) + oxidized [electron-transfer flavoprotein] + undecanoyl-CoA <=> reduced [electron-transfer flavoprotein] + trans-2-undecenoyl-CoA"}
{"X":49744,"RHEA_ID":58226,"compounds":"5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide => L-glutamyl-[protein] + NAD(+)"}
{"X":49745,"RHEA_ID":48205,"compounds":"H(+) + oxidized [electron-transfer flavoprotein] + pentadecanoyl-CoA => (2E)-pentadecenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":49746,"RHEA_ID":58228,"compounds":"L-asparaginyl-[protein] + NAD(+) = H(+) + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] + nicotinamide"}
{"X":49747,"RHEA_ID":48207,"compounds":"H(+) + oxidized [electron-transfer flavoprotein] + pentadecanoyl-CoA <=> (2E)-pentadecenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":49748,"RHEA_ID":51573,"DIRECTION":"LR","MASTER_ID":51572,"metacyc":"RXN-12849","compounds":"(25S)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (25S)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":49749,"RHEA_ID":61935,"compounds":"(S)-miconazole(in) + ATP + H2O <=> (S)-miconazole(out) + ADP + H(+) + phosphate"}
{"X":49750,"RHEA_ID":48210,"compounds":"(2E)-nonenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + nonanoyl-CoA + oxidized [electron-transfer flavoprotein]"}
{"X":49751,"RHEA_ID":48211,"compounds":"H(+) + nonanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> (2E)-nonenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":49752,"RHEA_ID":61938,"compounds":"ADP + cycloheximide(out) + H(+) + phosphate => ATP + cycloheximide(in) + H2O"}
{"X":49753,"RHEA_ID":48213,"compounds":"a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O => a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + N-acetyl-alpha-D-galactosamine"}
{"X":49754,"RHEA_ID":48214,"compounds":"a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + N-acetyl-alpha-D-galactosamine => a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O"}
{"X":49755,"RHEA_ID":48215,"compounds":"a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O <=> a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + N-acetyl-alpha-D-galactosamine"}
{"X":49756,"RHEA_ID":58238,"compounds":"H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-tyrosyl-[protein] => L-tyrosyl-[protein] + NAD(+)"}
{"X":49757,"RHEA_ID":48217,"compounds":"H(+) + hexacosanoyl-CoA + oxidized [electron-transfer flavoprotein] => (2E)-hexacosenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":49758,"RHEA_ID":48218,"compounds":"(2E)-hexacosenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + hexacosanoyl-CoA + oxidized [electron-transfer flavoprotein]"}
{"X":49759,"RHEA_ID":48219,"compounds":"H(+) + hexacosanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> (2E)-hexacosenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":49760,"RHEA_ID":51585,"compounds":"gamma-butyrobetainyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => crotonobetainyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":49761,"RHEA_ID":48221,"compounds":"H(+) + oxidized [electron-transfer flavoprotein] + tricosanoyl-CoA => (2E)-tricosenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":49762,"RHEA_ID":48222,"compounds":"(2E)-tricosenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + tricosanoyl-CoA"}
{"X":49763,"RHEA_ID":48223,"compounds":"H(+) + oxidized [electron-transfer flavoprotein] + tricosanoyl-CoA <=> (2E)-tricosenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":49764,"RHEA_ID":58246,"compounds":"ADP-D-ribose + L-lysyl-[protein] => H2O + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein]"}
{"X":49765,"RHEA_ID":48225,"compounds":"a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O => a neolactoside nLc4Cer(d18:1(4E)) + L-fucose"}
{"X":49766,"RHEA_ID":48226,"compounds":"a neolactoside nLc4Cer(d18:1(4E)) + L-fucose => a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O"}
{"X":49767,"RHEA_ID":48227,"compounds":"a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O <=> a neolactoside nLc4Cer(d18:1(4E)) + L-fucose"}
{"X":49768,"RHEA_ID":58250,"compounds":"ADP-D-ribose + H(+) + L-glutamyl-[protein] => 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + H2O"}
{"X":49769,"RHEA_ID":48229,"DIRECTION":"LR","MASTER_ID":48228,"ecocyc":"RXN-17363","metacyc":"RXN-17363","compounds":"a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] => a 1-lyso-glycerophospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]"}
{"X":49770,"RHEA_ID":48230,"compounds":"a 1-lyso-glycerophospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] => a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]"}
{"X":49771,"RHEA_ID":48231,"compounds":"a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] <=> a 1-lyso-glycerophospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]"}
{"X":49772,"RHEA_ID":51597,"DIRECTION":"LR","MASTER_ID":51596,"metacyc":"RXN-8579","compounds":"2 H(+) + O2 + p-xylene + 2 reduced [2Fe-2S]-[ferredoxin] => 4-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":49773,"RHEA_ID":48233,"DIRECTION":"LR","MASTER_ID":48232,"metacyc":"RXN-19376","compounds":"acetyl-CoA + L-glutamate 5-semialdehyde => CoA + H(+) + N-acetyl-L-glutamate 5-semialdehyde"}
{"X":49774,"RHEA_ID":48234,"compounds":"CoA + H(+) + N-acetyl-L-glutamate 5-semialdehyde => acetyl-CoA + L-glutamate 5-semialdehyde"}
{"X":49775,"RHEA_ID":58257,"compounds":"H2O + O-(ADP-D-ribosyl)-L-seryl-[protein] => ADP-D-ribose + L-seryl-[protein]"}
{"X":49776,"RHEA_ID":58258,"compounds":"ADP-D-ribose + L-seryl-[protein] => H2O + O-(ADP-D-ribosyl)-L-seryl-[protein]"}
{"X":49777,"RHEA_ID":48237,"DIRECTION":"LR","MASTER_ID":48236,"metacyc":"RXN-19597","compounds":"2 2-acetylphloroglucinol => 1,3,5-trihydroxybenzene + 2,4-diacetylphloroglucinol + H(+)"}
{"X":49778,"RHEA_ID":58260,"compounds":"H2O + O-(ADP-D-ribosyl)-L-tyrosyl-[protein] = ADP-D-ribose + L-tyrosyl-[protein]"}
{"X":49779,"RHEA_ID":58261,"compounds":"H2O + O-(ADP-D-ribosyl)-L-tyrosyl-[protein] => ADP-D-ribose + L-tyrosyl-[protein]"}
{"X":49780,"RHEA_ID":48240,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GD1b = CMP + ganglioside GT1b + H(+)"}
{"X":49781,"RHEA_ID":48241,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GD1b => CMP + ganglioside GT1b + H(+)"}
{"X":49782,"RHEA_ID":48242,"compounds":"CMP + ganglioside GT1b + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GD1b"}
{"X":49783,"RHEA_ID":48243,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GD1b <=> CMP + ganglioside GT1b + H(+)"}
{"X":49784,"RHEA_ID":48244,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GA1 = CMP + ganglioside GM1b + H(+)"}
{"X":49785,"RHEA_ID":48245,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GA1 => CMP + ganglioside GM1b + H(+)"}
{"X":49786,"RHEA_ID":58268,"compounds":"[protein]-C-terminal glycine + NAD(+) = [protein]-C-terminal O-(ADP-D-ribosyl)-glycine + nicotinamide"}
{"X":49787,"RHEA_ID":48247,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GA1 <=> CMP + ganglioside GM1b + H(+)"}
{"X":49788,"RHEA_ID":48248,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)/18:0) = CMP + ganglioside GD1a (18:1(4E)/18:0) + H(+)"}
{"X":49789,"RHEA_ID":48249,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)/18:0) => CMP + ganglioside GD1a (18:1(4E)/18:0) + H(+)"}
{"X":49790,"RHEA_ID":58276,"compounds":"6 ATP = cyclic hexaadenylate + 6 diphosphate"}
{"X":49791,"RHEA_ID":48251,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)/18:0) <=> CMP + ganglioside GD1a (18:1(4E)/18:0) + H(+)"}
{"X":49792,"RHEA_ID":48252,"compounds":"ganglioside GD2 + UDP-alpha-D-galactose = ganglioside GD1b + H(+) + UDP"}
{"X":49793,"RHEA_ID":58278,"compounds":"cyclic hexaadenylate + 6 diphosphate => 6 ATP"}
{"X":49794,"RHEA_ID":48254,"compounds":"ganglioside GD1b + H(+) + UDP => ganglioside GD2 + UDP-alpha-D-galactose"}
{"X":49795,"RHEA_ID":48255,"compounds":"ganglioside GD2 + UDP-alpha-D-galactose <=> ganglioside GD1b + H(+) + UDP"}
{"X":49796,"RHEA_ID":48256,"compounds":"(2S)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-2-methylbutenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":49797,"RHEA_ID":61983,"compounds":"H(+) + NADPH + ubiquinone-10 <=> NADP(+) + ubiquinol-10"}
{"X":49798,"RHEA_ID":58284,"DIRECTION":"UN","MASTER_ID":58284,"ec":"1.3.1.2","compounds":"5,6-dihydrothymine + NADP(+) = H(+) + NADPH + thymine"}
{"X":49799,"RHEA_ID":48259,"compounds":"(2S)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-2-methylbutenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":49800,"RHEA_ID":48260,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GM1a = CMP + ganglioside GD1a + H(+)"}
{"X":49801,"RHEA_ID":48261,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GM1a => CMP + ganglioside GD1a + H(+)"}
{"X":49802,"RHEA_ID":58288,"compounds":"25-substituted-cholesterol + beta-D-glucosyl-N-octanoylsphing-4E-enine = 25-substituted-cholesteryl beta-D-glucoside + N-octanoylsphing-4-enine"}
{"X":49803,"RHEA_ID":48263,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GM1a <=> CMP + ganglioside GD1a + H(+)"}
{"X":49804,"RHEA_ID":58290,"compounds":"25-substituted-cholesteryl beta-D-glucoside + N-octanoylsphing-4-enine => 25-substituted-cholesterol + beta-D-glucosyl-N-octanoylsphing-4E-enine"}
{"X":49805,"RHEA_ID":61990,"compounds":"5-methylcytidine(72) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(72) in tRNA + S-adenosyl-L-methionine"}
{"X":49806,"RHEA_ID":58292,"compounds":"25-substituted-cholesterol + beta-D-glucosyl-N-dodecanoylsphing-4E-enine = 25-substituted-cholesteryl beta-D-glucoside + N-dodecanoylsphing-4-enine"}
{"X":49807,"RHEA_ID":48268,"compounds":"4',4'-dihydroxyechinenone = canthaxanthin + H2O"}
{"X":49808,"RHEA_ID":48269,"DIRECTION":"LR","MASTER_ID":48268,"metacyc":"RXN-18966","compounds":"4',4'-dihydroxyechinenone => canthaxanthin + H2O"}
{"X":49809,"RHEA_ID":58296,"compounds":"25-substituted-cholesterol + beta-D-glucosyl-N-hexadecanoylsphing-4E-enine = 25-substituted-cholesteryl beta-D-glucoside + N-hexadecanoylsphing-4-enine"}
{"X":49810,"RHEA_ID":48271,"compounds":"4',4'-dihydroxyechinenone <=> canthaxanthin + H2O"}
{"X":49811,"RHEA_ID":58298,"compounds":"25-substituted-cholesteryl beta-D-glucoside + N-hexadecanoylsphing-4-enine => 25-substituted-cholesterol + beta-D-glucosyl-N-hexadecanoylsphing-4E-enine"}
{"X":49812,"RHEA_ID":48273,"compounds":"2-methylhexanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => 2-methylhexenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":49813,"RHEA_ID":58300,"compounds":"25-substituted-cholesterol + beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine = 25-substituted-cholesteryl beta-D-glucoside + N-octadecanoylsphing-4-enine"}
{"X":49814,"RHEA_ID":48275,"compounds":"2-methylhexanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> 2-methylhexenoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":49815,"RHEA_ID":48276,"compounds":"H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide = beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetyl-beta-D-galactosamine"}
{"X":49816,"RHEA_ID":48277,"compounds":"H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetyl-beta-D-galactosamine"}
{"X":49817,"RHEA_ID":58304,"compounds":"25-substituted-cholesterol + beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine = 25-substituted-cholesteryl beta-D-glucoside + N-(9Z-octadecenoyl)-sphing-4-enine"}
{"X":49818,"RHEA_ID":48279,"compounds":"H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide <=> beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetyl-beta-D-galactosamine"}
{"X":49819,"RHEA_ID":58306,"compounds":"25-substituted-cholesteryl beta-D-glucoside + N-(9Z-octadecenoyl)-sphing-4-enine => 25-substituted-cholesterol + beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine"}
{"X":49820,"RHEA_ID":48281,"compounds":"ganglioside GM2 + UDP-alpha-D-galactose => ganglioside GM1a + H(+) + UDP"}
{"X":49821,"RHEA_ID":58308,"compounds":"25-substituted-cholesterol + beta-D-glucosyl-N-(15Z-tetracosenoyl)-sphing-4E-enine = 25-substituted-cholesteryl beta-D-glucoside + N-(15Z-tetracosenoyl)-sphing-4-enine"}
{"X":49822,"RHEA_ID":48283,"compounds":"ganglioside GM2 + UDP-alpha-D-galactose <=> ganglioside GM1a + H(+) + UDP"}
{"X":49823,"RHEA_ID":58310,"compounds":"25-substituted-cholesteryl beta-D-glucoside + N-(15Z-tetracosenoyl)-sphing-4-enine => 25-substituted-cholesterol + beta-D-glucosyl-N-(15Z-tetracosenoyl)-sphing-4E-enine"}
{"X":49824,"RHEA_ID":48285,"compounds":"globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose => globoside NOR1 (d18:1(4E)) + H(+) + UDP"}
{"X":49825,"RHEA_ID":48286,"compounds":"globoside NOR1 (d18:1(4E)) + H(+) + UDP => globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose"}
{"X":49826,"RHEA_ID":48287,"compounds":"globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose <=> globoside NOR1 (d18:1(4E)) + H(+) + UDP"}
{"X":49827,"RHEA_ID":58314,"compounds":"25-substituted-cholesterol + D-glucose => 25-substituted-cholesteryl beta-D-glucoside + H2O"}
{"X":49828,"RHEA_ID":48289,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GM3 => CMP + ganglioside GD3 + H(+)"}
{"X":49829,"RHEA_ID":58316,"compounds":"beta-D-glucosyl-N-hexadecanoylsphing-4E-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine"}
{"X":49830,"RHEA_ID":48291,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GM3 <=> CMP + ganglioside GD3 + H(+)"}
{"X":49831,"RHEA_ID":58318,"compounds":"cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine => beta-D-glucosyl-N-hexadecanoylsphing-4E-enine + cholesterol"}
{"X":49832,"RHEA_ID":48293,"compounds":"ganglioside GM1a + GDP-beta-L-fucose => fucosyl ganglioside GM1 + GDP + H(+)"}
{"X":49833,"RHEA_ID":58320,"compounds":"25-substituted-cholesterol + a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine = 25-substituted-cholesteryl beta-D-glucoside + an N-acylsphing-4-enine"}
{"X":49834,"RHEA_ID":48295,"compounds":"ganglioside GM1a + GDP-beta-L-fucose <=> fucosyl ganglioside GM1 + GDP + H(+)"}
{"X":49835,"RHEA_ID":58322,"compounds":"25-substituted-cholesteryl beta-D-glucoside + an N-acylsphing-4-enine => 25-substituted-cholesterol + a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine"}
{"X":49836,"RHEA_ID":48297,"compounds":"H2O + prostaglandin E2 1-glyceryl ester => glycerol + H(+) + prostaglandin E2"}
{"X":49837,"RHEA_ID":48298,"compounds":"glycerol + H(+) + prostaglandin E2 => H2O + prostaglandin E2 1-glyceryl ester"}
{"X":49838,"RHEA_ID":48299,"compounds":"H2O + prostaglandin E2 1-glyceryl ester <=> glycerol + H(+) + prostaglandin E2"}
{"X":49839,"RHEA_ID":58326,"compounds":"cholesteryl 3-beta-D-glucoside + N-(9Z-octadecenoyl)-sphing-4-enine => beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine + cholesterol"}
{"X":49840,"RHEA_ID":48301,"compounds":"H2O + prostaglandin F2alpha 1-glyceryl ester => glycerol + H(+) + prostaglandin F2alpha"}
{"X":49841,"RHEA_ID":52782,"compounds":"2-sulfenohercynine + NH4(+) + pyruvate => H2O + S-(hercyn-2-yl)-L-cysteine S-oxide"}
{"X":49842,"RHEA_ID":48303,"compounds":"H2O + prostaglandin F2alpha 1-glyceryl ester <=> glycerol + H(+) + prostaglandin F2alpha"}
{"X":49843,"RHEA_ID":48304,"compounds":"a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose = a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)"}
{"X":49844,"RHEA_ID":48305,"compounds":"a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose => a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)"}
{"X":49845,"RHEA_ID":58332,"compounds":"(E)-non-2-en-1-ol + NADP(+) = (E)-non-2-enal + H(+) + NADPH"}
{"X":49846,"RHEA_ID":48307,"compounds":"a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose <=> a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)"}
{"X":49847,"RHEA_ID":58334,"compounds":"(E)-non-2-enal + H(+) + NADPH => (E)-non-2-en-1-ol + NADP(+)"}
{"X":49848,"RHEA_ID":48309,"DIRECTION":"LR","MASTER_ID":48308,"metacyc":"RXN-11054","compounds":"2,3-epoxy-2,3-dihydrobenzoyl-CoA + 2 H2O => (3Z)-6-oxohex-3-enoyl-CoA + formate + H(+)"}
{"X":49849,"RHEA_ID":58336,"compounds":"a 4-hydroxynonen-1-ol + NADP(+) = a 4-hydroxynonenal + H(+) + NADPH"}
{"X":49850,"RHEA_ID":48311,"compounds":"2,3-epoxy-2,3-dihydrobenzoyl-CoA + 2 H2O <=> (3Z)-6-oxohex-3-enoyl-CoA + formate + H(+)"}
{"X":49851,"RHEA_ID":48312,"DIRECTION":"UN","MASTER_ID":48312,"ec":"1.14.13.208","compounds":"benzoyl-CoA + H(+) + NADPH + O2 = 2,3-epoxy-2,3-dihydrobenzoyl-CoA + H2O + NADP(+)"}
{"X":49852,"RHEA_ID":48313,"DIRECTION":"LR","MASTER_ID":48312,"metacyc":"RXN-2401","compounds":"benzoyl-CoA + H(+) + NADPH + O2 => 2,3-epoxy-2,3-dihydrobenzoyl-CoA + H2O + NADP(+)"}
{"X":49853,"RHEA_ID":48314,"compounds":"2,3-epoxy-2,3-dihydrobenzoyl-CoA + H2O + NADP(+) => benzoyl-CoA + H(+) + NADPH + O2"}
{"X":49854,"RHEA_ID":51680,"DIRECTION":"UN","MASTER_ID":51680,"ec":"2.7.1.216","compounds":"(2E,6E)-farnesol + CTP = (2E,6E)-farnesyl phosphate + CDP + H(+)"}
{"X":49855,"RHEA_ID":48316,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GM1b = CMP + ganglioside GD1aalpha + H(+)"}
{"X":49856,"RHEA_ID":48317,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GM1b => CMP + ganglioside GD1aalpha + H(+)"}
{"X":49857,"RHEA_ID":62044,"compounds":"a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphoglycerol + H2O = (9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphoglycerol + H(+)"}
{"X":49858,"RHEA_ID":48319,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GM1b <=> CMP + ganglioside GD1aalpha + H(+)"}
{"X":49859,"RHEA_ID":58346,"compounds":"D-glucose + lithocholate => beta-D-glucosyl-(1->3)-O-lithocholate + H2O"}
{"X":49860,"RHEA_ID":48321,"compounds":"ganglioside GA1 + GDP-beta-L-fucose => fucosyl ganglioside GA1 + GDP + H(+)"}
{"X":49861,"RHEA_ID":48322,"compounds":"fucosyl ganglioside GA1 + GDP + H(+) => ganglioside GA1 + GDP-beta-L-fucose"}
{"X":49862,"RHEA_ID":48323,"compounds":"ganglioside GA1 + GDP-beta-L-fucose <=> fucosyl ganglioside GA1 + GDP + H(+)"}
{"X":49863,"RHEA_ID":58350,"compounds":"2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate => 2 2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 O2"}
{"X":49864,"RHEA_ID":58351,"compounds":"2 2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 O2 <=> 2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate"}
{"X":49865,"RHEA_ID":48326,"compounds":"ganglioside fucosyl GD1b + GDP + H(+) => ganglioside GD1b + GDP-beta-L-fucose"}
{"X":49866,"RHEA_ID":48327,"compounds":"ganglioside GD1b + GDP-beta-L-fucose <=> ganglioside fucosyl GD1b + GDP + H(+)"}
{"X":49867,"RHEA_ID":48328,"compounds":"a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose = GDP + H(+) + III(4)-a-Fuc-Lc4Cer(d18:1(4E))"}
{"X":49868,"RHEA_ID":48329,"compounds":"a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose => GDP + H(+) + III(4)-a-Fuc-Lc4Cer(d18:1(4E))"}
{"X":49869,"RHEA_ID":48330,"compounds":"GDP + H(+) + III(4)-a-Fuc-Lc4Cer(d18:1(4E)) => a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose"}
{"X":49870,"RHEA_ID":51696,"DIRECTION":"UN","MASTER_ID":51696,"ec":"2.1.1.338","compounds":"desmethylxanthohumol + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + xanthohumol"}
{"X":49871,"RHEA_ID":58358,"compounds":"CO2 + formaldehyde + L-arginyl-[protein] + succinate => 2-oxoglutarate + N(omega)-methyl-L-arginyl-[protein] + O2"}
{"X":49872,"RHEA_ID":48333,"compounds":"a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose => a neolactoside III(3)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)"}
{"X":49873,"RHEA_ID":48334,"compounds":"a neolactoside III(3)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+) => a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose"}
{"X":49874,"RHEA_ID":48335,"compounds":"a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose <=> a neolactoside III(3)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)"}
{"X":49875,"RHEA_ID":48336,"compounds":"a neolactoside nLc6Cer(d18:1(4E)) + GDP-beta-L-fucose = a neolactoside III(3)-alpha-Fuc-nLc6Cer(d18:1(4E)) + GDP + H(+)"}
{"X":49876,"RHEA_ID":48337,"compounds":"a neolactoside nLc6Cer(d18:1(4E)) + GDP-beta-L-fucose => a neolactoside III(3)-alpha-Fuc-nLc6Cer(d18:1(4E)) + GDP + H(+)"}
{"X":49877,"RHEA_ID":58364,"compounds":"a medium-chain primary fatty alcohol + NADP(+) = a medium-chain fatty aldehyde + H(+) + NADPH"}
{"X":49878,"RHEA_ID":48339,"compounds":"a neolactoside nLc6Cer(d18:1(4E)) + GDP-beta-L-fucose <=> a neolactoside III(3)-alpha-Fuc-nLc6Cer(d18:1(4E)) + GDP + H(+)"}
{"X":49879,"RHEA_ID":48340,"DIRECTION":"UN","MASTER_ID":48340,"ec":"6.2.1.2","compounds":"a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate"}
{"X":49880,"RHEA_ID":58367,"compounds":"a medium-chain primary fatty alcohol + NADP(+) <=> a medium-chain fatty aldehyde + H(+) + NADPH"}
{"X":49881,"RHEA_ID":58368,"compounds":"(2E,6Z)-nona-2,6-dien-1-ol + NADP(+) = (2E,6Z)-nona-2,6-dienal + H(+) + NADPH"}
{"X":49882,"RHEA_ID":51708,"DIRECTION":"UN","MASTER_ID":51708,"ec":"1.1.1.407","compounds":"D-altritol + NAD(+) = H(+) + keto-D-tagatose + NADH"}
{"X":49883,"RHEA_ID":48344,"compounds":"N-acyl-sphingoid base + UDP-alpha-D-galactose = a D-galactosylceramide + H(+) + UDP"}
{"X":49884,"RHEA_ID":48345,"compounds":"N-acyl-sphingoid base + UDP-alpha-D-galactose => a D-galactosylceramide + H(+) + UDP"}
{"X":49885,"RHEA_ID":62072,"compounds":"D-galactose 6-phosphate + NADP(+) = 6-phospho-D-galactono-1,5-lactone + H(+) + NADPH"}
{"X":49886,"RHEA_ID":51712,"DIRECTION":"UN","MASTER_ID":51712,"ec":"5.1.3.40","compounds":"keto-D-tagatose 6-phosphate = keto-D-fructose 6-phosphate"}
{"X":49887,"RHEA_ID":48348,"compounds":"a uridine in RNA = a pseudouridine in RNA"}
{"X":49888,"RHEA_ID":48349,"compounds":"a uridine in RNA => a pseudouridine in RNA"}
{"X":49889,"RHEA_ID":62076,"compounds":"D-galactose 6-phosphate + NAD(+) = 6-phospho-D-galactono-1,5-lactone + H(+) + NADH"}
{"X":49890,"RHEA_ID":51716,"compounds":"ATP(in) + CoA(in) + H(+)(out) + hexadecanoate(out) = AMP(in) + diphosphate(in) + H(+)(in) + hexadecanoyl-CoA(in)"}
{"X":49891,"RHEA_ID":48352,"compounds":"GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide = GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide"}
{"X":49892,"RHEA_ID":48353,"compounds":"GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide"}
{"X":49893,"RHEA_ID":58380,"compounds":"NADP(+) + nonan-1-ol = H(+) + NADPH + nonanal"}
{"X":49894,"RHEA_ID":51720,"compounds":"ATP(in) + CoA(in) + H(+)(out) + octadecanoate(out) = AMP(in) + diphosphate(in) + H(+)(in) + octadecanoyl-CoA(in)"}
{"X":49895,"RHEA_ID":48356,"compounds":"GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide = GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide"}
{"X":49896,"RHEA_ID":48357,"compounds":"GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide"}
{"X":49897,"RHEA_ID":58384,"compounds":"NADP(+) + octan-1-ol = H(+) + NADPH + octanal"}
{"X":49898,"RHEA_ID":48359,"compounds":"GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide <=> GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide"}
{"X":49899,"RHEA_ID":48360,"DIRECTION":"UN","MASTER_ID":48360,"ec":"1.11.2.4","compounds":"a 1,2-saturated fatty acid + H2O2 = a 2-hydroxy fatty acid + H2O"}
{"X":49900,"RHEA_ID":58387,"compounds":"NADP(+) + octan-1-ol <=> H(+) + NADPH + octanal"}
{"X":49901,"RHEA_ID":58388,"compounds":"4-aminobenzoate + all-trans-hexaprenyl diphosphate = 4-amino-3-all-trans-hexaprenylbenzoate + diphosphate"}
{"X":49902,"RHEA_ID":58390,"compounds":"4-amino-3-all-trans-hexaprenylbenzoate + diphosphate => 4-aminobenzoate + all-trans-hexaprenyl diphosphate"}
{"X":49903,"RHEA_ID":48365,"compounds":"beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose => beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)"}
{"X":49904,"RHEA_ID":58392,"compounds":"4-amino-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":49905,"RHEA_ID":48367,"compounds":"beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose <=> beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)"}
{"X":49906,"RHEA_ID":48368,"compounds":"beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose = beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)"}
{"X":49907,"RHEA_ID":58395,"compounds":"4-amino-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":49908,"RHEA_ID":48370,"compounds":"beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+) => beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose"}
{"X":49909,"RHEA_ID":48371,"compounds":"beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose <=> beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)"}
{"X":49910,"RHEA_ID":48372,"compounds":"1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = a fatty acid + acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+)"}
{"X":49911,"RHEA_ID":48373,"compounds":"1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O => a fatty acid + acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+)"}
{"X":49912,"RHEA_ID":58400,"compounds":"heptan-1-ol + NADP(+) = H(+) + heptanal + NADPH"}
{"X":49913,"RHEA_ID":48375,"compounds":"1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O <=> a fatty acid + acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+)"}
{"X":49914,"RHEA_ID":48376,"compounds":"a neolactoside nLc4Cer + GDP-beta-L-fucose = a neolactoside III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)"}
{"X":49915,"RHEA_ID":48377,"compounds":"a neolactoside nLc4Cer + GDP-beta-L-fucose => a neolactoside III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)"}
{"X":49916,"RHEA_ID":58404,"compounds":"hexan-1-ol + NADP(+) = H(+) + hexanal + NADPH"}
{"X":49917,"RHEA_ID":48379,"compounds":"a neolactoside nLc4Cer + GDP-beta-L-fucose <=> a neolactoside III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)"}
{"X":49918,"RHEA_ID":48380,"compounds":"alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose = alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)"}
{"X":49919,"RHEA_ID":48381,"compounds":"alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose => alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)"}
{"X":49920,"RHEA_ID":58408,"compounds":"NADP(+) + undecan-1-ol = H(+) + NADPH + undecanal"}
{"X":49921,"RHEA_ID":48383,"compounds":"alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose <=> alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)"}
{"X":49922,"RHEA_ID":58410,"compounds":"H(+) + NADPH + undecanal => NADP(+) + undecan-1-ol"}
{"X":49923,"RHEA_ID":48385,"compounds":"2,3-saturated fatty acid + H2O2 => 3-hydroxy fatty acid + H2O"}
{"X":49924,"RHEA_ID":62112,"compounds":"(3S)-3-hydroxy-D-aspartate = H2O + iminosuccinate"}
{"X":49925,"RHEA_ID":58414,"compounds":"H2O + L-homocysteine + 2 oxidized [2Fe-2S]-[ferredoxin] => 3 H(+) + hydrogen sulfide + L-aspartate 4-semialdehyde + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":49926,"RHEA_ID":48389,"compounds":"alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose => alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)"}
{"X":49927,"RHEA_ID":48390,"compounds":"alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+) => alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose"}
{"X":49928,"RHEA_ID":58417,"compounds":"(E)-4-hydroxynon-2-en-1-ol + NADP(+) => (E)-4-hydroxynon-2-enal + H(+) + NADPH"}
{"X":49929,"RHEA_ID":58418,"compounds":"(E)-4-hydroxynon-2-enal + H(+) + NADPH => (E)-4-hydroxynon-2-en-1-ol + NADP(+)"}
{"X":49930,"RHEA_ID":48393,"compounds":"GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide"}
{"X":49931,"RHEA_ID":58420,"compounds":"NADP(+) + prenol = 3-methyl-2-butenal + H(+) + NADPH"}
{"X":49932,"RHEA_ID":58421,"compounds":"NADP(+) + prenol => 3-methyl-2-butenal + H(+) + NADPH"}
{"X":49933,"RHEA_ID":62126,"compounds":"a 2'-deoxyribonucleoside 5'-diphosphate + GDP => a 2'-deoxyribonucleoside 5'-phosphate + GTP"}
{"X":49934,"RHEA_ID":48397,"compounds":"(3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + S-adenosyl-L-methionine => 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one + H(+) + S-adenosyl-L-homocysteine"}
{"X":49935,"RHEA_ID":58424,"compounds":"(E)-hex-2-en-1-ol + NADP(+) = (E)-2-hexenal + H(+) + NADPH"}
{"X":49936,"RHEA_ID":48399,"compounds":"(3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + S-adenosyl-L-methionine <=> 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one + H(+) + S-adenosyl-L-homocysteine"}
{"X":49937,"RHEA_ID":62130,"compounds":"a 2'-deoxyribonucleoside 5'-diphosphate + dGDP => a 2'-deoxyribonucleoside 5'-phosphate + dGTP"}
{"X":49938,"RHEA_ID":48401,"DIRECTION":"LR","MASTER_ID":48400,"metacyc":"RXN-11320","compounds":"2-oxoglutarate + [hypoxia-inducible factor alpha subunit]-L-proline + O2 => [hypoxia-inducible factor alpha subunit]-trans-4-hydroxy-L-proline + CO2 + succinate"}
{"X":49939,"RHEA_ID":48402,"compounds":"[hypoxia-inducible factor alpha subunit]-trans-4-hydroxy-L-proline + CO2 + succinate => 2-oxoglutarate + [hypoxia-inducible factor alpha subunit]-L-proline + O2"}
{"X":49940,"RHEA_ID":48403,"compounds":"2-oxoglutarate + [hypoxia-inducible factor alpha subunit]-L-proline + O2 <=> [hypoxia-inducible factor alpha subunit]-trans-4-hydroxy-L-proline + CO2 + succinate"}
{"X":49941,"RHEA_ID":48404,"compounds":"apo-[EntB isochorismatase/aryl-carrier protein] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[EntB isochorismatase/aryl-carrier protein]"}
{"X":49942,"RHEA_ID":48405,"compounds":"apo-[EntB isochorismatase/aryl-carrier protein] + CoA => adenosine 3',5'-bisphosphate + H(+) + holo-[EntB isochorismatase/aryl-carrier protein]"}
{"X":49943,"RHEA_ID":48406,"compounds":"adenosine 3',5'-bisphosphate + H(+) + holo-[EntB isochorismatase/aryl-carrier protein] => apo-[EntB isochorismatase/aryl-carrier protein] + CoA"}
{"X":49944,"RHEA_ID":58433,"compounds":"(E)-4-oxonon-2-en-1-ol + NADP(+) => (E)-4-oxonon-2-enal + H(+) + NADPH"}
{"X":49945,"RHEA_ID":48408,"compounds":"apo-[EntF peptidyl-carrier protein] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[EntF peptidyl-carrier protein]"}
{"X":49946,"RHEA_ID":48409,"compounds":"apo-[EntF peptidyl-carrier protein] + CoA => adenosine 3',5'-bisphosphate + H(+) + holo-[EntF peptidyl-carrier protein]"}
{"X":49947,"RHEA_ID":48410,"compounds":"adenosine 3',5'-bisphosphate + H(+) + holo-[EntF peptidyl-carrier protein] => apo-[EntF peptidyl-carrier protein] + CoA"}
{"X":49948,"RHEA_ID":58437,"compounds":"4-methylpentan-1-ol + NADP(+) => 4-methylpentanal + H(+) + NADPH"}
{"X":49949,"RHEA_ID":58438,"DIRECTION":"RL","MASTER_ID":58436,"reactome":"R-HSA-196060.3","compounds":"4-methylpentanal + H(+) + NADPH => 4-methylpentan-1-ol + NADP(+)"}
{"X":49950,"RHEA_ID":48413,"compounds":"globoside IV3GalNAc-Gb4Cer + H2O => globoside Gb4Cer + N-acetyl-alpha-D-galactosamine"}
{"X":49951,"RHEA_ID":48414,"compounds":"globoside Gb4Cer + N-acetyl-alpha-D-galactosamine => globoside IV3GalNAc-Gb4Cer + H2O"}
{"X":49952,"RHEA_ID":58441,"compounds":"N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-methionine => 3 H(+) + N-terminal N,N,N-trimethyl-L-glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-homocysteine"}
{"X":49953,"RHEA_ID":51781,"DIRECTION":"LR","MASTER_ID":51780,"metacyc":"RXN-18445","compounds":"4-prenylphlormethylbutanophenone + dimethylallyl diphosphate => deoxyadlupulone + diphosphate"}
{"X":49954,"RHEA_ID":48417,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E)) => CMP + ganglioside GM2 (d18:1(4E)) + H(+)"}
{"X":49955,"RHEA_ID":48418,"compounds":"CMP + ganglioside GM2 (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E))"}
{"X":49956,"RHEA_ID":58445,"compounds":"N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N-methyl-L-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":49957,"RHEA_ID":51785,"DIRECTION":"LR","MASTER_ID":51784,"metacyc":"RXN-7810","compounds":"4-prenylphlorisovalerophenone + dimethylallyl diphosphate => deoxyhumulone + diphosphate"}
{"X":49958,"RHEA_ID":48421,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)) => CMP + ganglioside GM1 (d18:1(4E)) + H(+)"}
{"X":49959,"RHEA_ID":48422,"compounds":"CMP + ganglioside GM1 (d18:1(4E)) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E))"}
{"X":49960,"RHEA_ID":58449,"compounds":"N-terminal N-methyl-L-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N-dimethyl-L-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":49961,"RHEA_ID":51789,"DIRECTION":"LR","MASTER_ID":51788,"metacyc":"RXN-11739","compounds":"2-hydroxybenzoyl-5'-AMP + CoA => 2-hydroxybenzoyl-CoA + AMP + H(+)"}
{"X":49962,"RHEA_ID":48425,"compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H2O => (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dUMP"}
{"X":49963,"RHEA_ID":62160,"compounds":"H2O + N-(9Z-octadecenoyl)-ethanolamine phosphate = N-(9Z-octadecenoyl) ethanolamine + phosphate"}
{"X":49964,"RHEA_ID":58453,"compounds":"N-terminal N,N-dimethyl-L-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N,N-trimethyl-L-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":49965,"RHEA_ID":58454,"compounds":"H(+) + N-terminal N,N,N-trimethyl-L-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N,N-dimethyl-L-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine"}
{"X":49966,"RHEA_ID":48429,"compounds":"1-(9Z,12Z-octadecadienoyl)-glycerol + H2O => (9Z,12Z)-octadecadienoate + glycerol + H(+)"}
{"X":49967,"RHEA_ID":48430,"compounds":"(9Z,12Z)-octadecadienoate + glycerol + H(+) => 1-(9Z,12Z-octadecadienoyl)-glycerol + H2O"}
{"X":49968,"RHEA_ID":58457,"DIRECTION":"LR","MASTER_ID":58456,"metacyc":"RXN-14900","compounds":"(2R)-2-O-(alpha-D-mannosyl)-glycerate + H2O => (R)-glycerate + D-mannose"}
{"X":49969,"RHEA_ID":51797,"DIRECTION":"LR","MASTER_ID":51796,"metacyc":"RXN-18449","compounds":"deoxycohumulone + dimethylallyl diphosphate => colupulone + diphosphate + H(+)"}
{"X":49970,"RHEA_ID":48433,"compounds":"ATP + N(6)-D-ribulosyl-L-lysyl-[protein] => ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein]"}
{"X":49971,"RHEA_ID":48434,"compounds":"ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] => ATP + N(6)-D-ribulosyl-L-lysyl-[protein]"}
{"X":49972,"RHEA_ID":48435,"DIRECTION":"BI","MASTER_ID":48432,"metacyc":"RXN-12003","compounds":"ATP + N(6)-D-ribulosyl-L-lysyl-[protein] <=> ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein]"}
{"X":49973,"RHEA_ID":58462,"compounds":"a monoacyl-sn-glycero-3-phosphocholine + CoA => an acyl-CoA + sn-glycerol 3-phosphocholine"}
{"X":49974,"RHEA_ID":48437,"compounds":"H2O + pentanoate ester => an aliphatic alcohol + H(+) + pentanoate"}
{"X":49975,"RHEA_ID":62172,"compounds":"an N-acylethanolamine phosphate + H2O = an N-acylethanolamine + phosphate"}
{"X":49976,"RHEA_ID":48439,"compounds":"H2O + pentanoate ester <=> an aliphatic alcohol + H(+) + pentanoate"}
{"X":49977,"RHEA_ID":58466,"compounds":"a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + H(+) + UDP => a neolactoside nLc4Cer + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":49978,"RHEA_ID":48441,"compounds":"H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol => a fatty acid + H(+) + long chain 2-acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol"}
{"X":49979,"RHEA_ID":51807,"compounds":"deoxyhumulone + dimethylallyl diphosphate <=> diphosphate + H(+) + lupulone"}
{"X":49980,"RHEA_ID":48443,"compounds":"H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol <=> a fatty acid + H(+) + long chain 2-acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol"}
{"X":49981,"RHEA_ID":51809,"compounds":"(9Z)-octadecenoate(out) + ATP(in) + CoA(in) + H(+)(out) => (9Z)-octadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)"}
{"X":49982,"RHEA_ID":48445,"compounds":"H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol => a fatty acid + H(+) + long chain 2-acyl-3-O-beta-D-galactosyl-sn-glycerol"}
{"X":49983,"RHEA_ID":62180,"compounds":"H2O + peregrinol diphosphate = diphosphate + viteagnusin D"}
{"X":49984,"RHEA_ID":48447,"compounds":"H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol <=> a fatty acid + H(+) + long chain 2-acyl-3-O-beta-D-galactosyl-sn-glycerol"}
{"X":49985,"RHEA_ID":58474,"compounds":"CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate => 2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + O2"}
{"X":49986,"RHEA_ID":62183,"compounds":"H2O + peregrinol diphosphate <=> diphosphate + viteagnusin D"}
{"X":49987,"RHEA_ID":62184,"compounds":"peregrinol diphosphate = diphosphate + labd-13(16),14-diene-9-ol"}
{"X":49988,"RHEA_ID":48451,"compounds":"H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide <=> beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetyl-beta-D-galactosamine"}
{"X":49989,"RHEA_ID":58478,"compounds":"a 1-acyl-sn-glycero-3-phosphocholine + CoA => an acyl-CoA + sn-glycerol 3-phosphocholine"}
{"X":49990,"RHEA_ID":62187,"compounds":"peregrinol diphosphate <=> diphosphate + labd-13(16),14-diene-9-ol"}
{"X":49991,"RHEA_ID":62188,"compounds":"9alpha-copalyl diphosphate = diphosphate + syn-isopimara-7,15-diene"}
{"X":49992,"RHEA_ID":48455,"compounds":"ganglioside GA2 (d18:1(4E)) + H2O <=> a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetyl-beta-D-galactosamine"}
{"X":49993,"RHEA_ID":58482,"compounds":"ADP + an N(4)-acetylcytidine in mRNA + CoA + H(+) + phosphate => a cytidine in mRNA + acetyl-CoA + ATP + H2O"}
{"X":49994,"RHEA_ID":48457,"compounds":"1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O => 2-octanoyl-3-O-beta-D-galactosyl-sn-glycerol + H(+) + octanoate"}
{"X":49995,"RHEA_ID":62192,"compounds":"O2 + peregrinol + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + labd-13Z-ene-9,15,16-triol + oxidized [NADPH--hemoprotein reductase]"}
{"X":49996,"RHEA_ID":48459,"compounds":"1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O <=> 2-octanoyl-3-O-beta-D-galactosyl-sn-glycerol + H(+) + octanoate"}
{"X":49997,"RHEA_ID":48460,"compounds":"1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = 2-octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + octanoate"}
{"X":49998,"RHEA_ID":48461,"compounds":"1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O => 2-octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + octanoate"}
{"X":49999,"RHEA_ID":48462,"compounds":"2-octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + octanoate => 1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O"}
{"X":50000,"RHEA_ID":48463,"compounds":"1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O <=> 2-octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + octanoate"}
{"X":50001,"RHEA_ID":48464,"compounds":"ganglioside GM1b + H2O = ganglioside GA1 + N-acetylneuraminate"}
{"X":50002,"RHEA_ID":48465,"compounds":"ganglioside GM1b + H2O => ganglioside GA1 + N-acetylneuraminate"}
{"X":50003,"RHEA_ID":48466,"compounds":"ganglioside GA1 + N-acetylneuraminate => ganglioside GM1b + H2O"}
{"X":50004,"RHEA_ID":48467,"compounds":"ganglioside GM1b + H2O <=> ganglioside GA1 + N-acetylneuraminate"}
{"X":50005,"RHEA_ID":58494,"compounds":"ADP + Fe(III)-enterobactin(in) + H(+) + phosphate => ATP + Fe(III)-enterobactin(out) + H2O"}
{"X":50006,"RHEA_ID":48469,"compounds":"ganglioside GM1b (d18:1(4E)) + H2O => ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate"}
{"X":50007,"RHEA_ID":48470,"compounds":"ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate => ganglioside GM1b (d18:1(4E)) + H2O"}
{"X":50008,"RHEA_ID":48471,"compounds":"ganglioside GM1b (d18:1(4E)) + H2O <=> ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate"}
{"X":50009,"RHEA_ID":58498,"compounds":"glycolaldehyde + H2O + NAD(+) + trimethylamine => choline + H(+) + NADH + O2"}
{"X":50010,"RHEA_ID":48473,"compounds":"ganglioside GT1a + H2O => ganglioside GD1a + N-acetylneuraminate"}
{"X":50011,"RHEA_ID":48474,"compounds":"ganglioside GD1a + N-acetylneuraminate => ganglioside GT1a + H2O"}
{"X":50012,"RHEA_ID":62209,"DIRECTION":"LR","MASTER_ID":62208,"metacyc":"RXN-15470","compounds":"3-methylphenol + O2 + reduced [NADPH--hemoprotein reductase] => 3-hydroxybenzyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50013,"RHEA_ID":51845,"compounds":"(9Z)-hexadecenoate(out) + ATP(in) + CoA(in) + H(+)(out) => (9Z)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)"}
{"X":50014,"RHEA_ID":48477,"compounds":"ganglioside GT1a (d18:1(4E)) + H2O => ganglioside GD1a (18:1(4E)) + N-acetylneuraminate"}
{"X":50015,"RHEA_ID":48478,"compounds":"ganglioside GD1a (18:1(4E)) + N-acetylneuraminate => ganglioside GT1a (d18:1(4E)) + H2O"}
{"X":50016,"RHEA_ID":48479,"compounds":"ganglioside GT1a (d18:1(4E)) + H2O <=> ganglioside GD1a (18:1(4E)) + N-acetylneuraminate"}
{"X":50017,"RHEA_ID":58506,"compounds":"(3Z)-2-oxo-4-carboxy-3-hexenedioate => (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate"}
{"X":50018,"RHEA_ID":62215,"compounds":"3-hydroxybenzyl alcohol + O2 + reduced [NADPH--hemoprotein reductase] <=> gentisyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50019,"RHEA_ID":62216,"compounds":"isoepoxydon + NADP(+) = H(+) + NADPH + phyllostine"}
{"X":50020,"RHEA_ID":48483,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + UDP-alpha-D-galactose <=> 1,2-di-(9Z-octadecenoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP"}
{"X":50021,"RHEA_ID":58510,"compounds":"(2S)-2-hydroxy-4-oxobutane-1,2,4-tricarboxylate => (3Z)-2-oxo-4-carboxy-3-hexenedioate + H2O"}
{"X":50022,"RHEA_ID":48485,"compounds":"a propanoate ester + H2O => an aliphatic alcohol + H(+) + propanoate"}
{"X":50023,"RHEA_ID":51855,"compounds":"(9Z,12Z)-octadecadienoate(out) + ATP(in) + CoA(in) + H(+)(out) <=> (9Z,12Z)-octadecadienoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)"}
{"X":50024,"RHEA_ID":48487,"compounds":"a propanoate ester + H2O <=> an aliphatic alcohol + H(+) + propanoate"}
{"X":50025,"RHEA_ID":51857,"compounds":"(E)-hexadec-2-enoate(out) + ATP(in) + CoA(in) + H(+)(out) => (2E)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)"}
{"X":50026,"RHEA_ID":48489,"DIRECTION":"LR","MASTER_ID":48488,"metacyc":"RXN-12581","compounds":"all-trans-retinol--[retinol-binding protein] + NAD(+) => all-trans-retinal--[retinol-binding protein] + H(+) + NADH"}
{"X":50027,"RHEA_ID":62224,"compounds":"H(+) + NADPH + neopatulin = (E)-ascladiol + NADP(+)"}
{"X":50028,"RHEA_ID":48491,"compounds":"all-trans-retinol--[retinol-binding protein] + NAD(+) <=> all-trans-retinal--[retinol-binding protein] + H(+) + NADH"}
{"X":50029,"RHEA_ID":48492,"compounds":"1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + UDP-alpha-D-galactose = 1,2-di-(9Z,12Z-octadecadienoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP"}
{"X":50030,"RHEA_ID":58519,"compounds":"(19S)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] <=> 15alpha-stemmadenine intermediate I + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50031,"RHEA_ID":48494,"compounds":"1,2-di-(9Z,12Z-octadecadienoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + UDP-alpha-D-galactose"}
{"X":50032,"RHEA_ID":48495,"compounds":"1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + UDP-alpha-D-galactose <=> 1,2-di-(9Z,12Z-octadecadienoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP"}
{"X":50033,"RHEA_ID":58522,"compounds":"akuammicine + formate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (19S)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":50034,"RHEA_ID":58523,"compounds":"(19S)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] <=> akuammicine + formate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50035,"RHEA_ID":55181,"compounds":"2-oxoglutarate + 3-methylnonanoyl-CoA + O2 => 2-hydroxy-3-methylnonanoyl-CoA + CO2 + succinate"}
{"X":50036,"RHEA_ID":48499,"compounds":"1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + UDP-alpha-D-galactose <=> 1-(9Z-octadecenoyl)-2-hexadecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP"}
{"X":50037,"RHEA_ID":58526,"compounds":"(16S)-deshydroxymethyl-stemmadenine + formate + NADP(+) => 15alpha-stemmadenine intermediate I + H2O + NADPH"}
{"X":50038,"RHEA_ID":58527,"compounds":"15alpha-stemmadenine intermediate I + H2O + NADPH <=> (16S)-deshydroxymethyl-stemmadenine + formate + NADP(+)"}
{"X":50039,"RHEA_ID":55185,"compounds":"2-oxoglutarate + 3-methylundecanoyl-CoA + O2 => 2-hydroxy-3-methylundecanoyl-CoA + CO2 + succinate"}
{"X":50040,"RHEA_ID":48503,"compounds":"H2O + octanoylglycerol <=> glycerol + H(+) + octanoate"}
{"X":50041,"RHEA_ID":58530,"compounds":"(16R)-deshydroxymethyl-stemmadenine + formate + NADP(+) => 15alpha-stemmadenine intermediate I + H2O + NADPH"}
{"X":50042,"RHEA_ID":58531,"compounds":"15alpha-stemmadenine intermediate I + H2O + NADPH <=> (16R)-deshydroxymethyl-stemmadenine + formate + NADP(+)"}
{"X":50043,"RHEA_ID":48506,"compounds":"D-glycero-D-manno-heptose 1-phosphate + phosphate => D-glycero-D-manno-heptose 1,7-bisphosphate + H2O"}
{"X":50044,"RHEA_ID":48507,"compounds":"D-glycero-D-manno-heptose 1,7-bisphosphate + H2O <=> D-glycero-D-manno-heptose 1-phosphate + phosphate"}
{"X":50045,"RHEA_ID":58534,"compounds":"akuammicine + formate + H(+) => 15alpha-stemmadenine intermediate I + H2O"}
{"X":50046,"RHEA_ID":48509,"compounds":"cholate + NADP(+) => 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH"}
{"X":50047,"RHEA_ID":62244,"DIRECTION":"UN","MASTER_ID":62244,"ec":"4.1.99.13","compounds":"a cytidine(6-4)thymidine in DNA = a cytidine-thymine dinucleotide in DNA"}
{"X":50048,"RHEA_ID":48511,"compounds":"cholate + NADP(+) <=> 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH"}
{"X":50049,"RHEA_ID":58538,"compounds":"CoA + H(+) + N-hexadecanoylglycine => glycine + hexadecanoyl-CoA"}
{"X":50050,"RHEA_ID":58539,"compounds":"glycine + hexadecanoyl-CoA <=> CoA + H(+) + N-hexadecanoylglycine"}
{"X":50051,"RHEA_ID":62248,"compounds":"chloroacetaldehyde + H2O + NADP(+) = chloroacetate + 2 H(+) + NADPH"}
{"X":50052,"RHEA_ID":48515,"compounds":"ATP + H2O + phosphinate(out) <=> ADP + H(+) + phosphate + phosphinate(in)"}
{"X":50053,"RHEA_ID":58542,"compounds":"H2O + 2 monodehydro-L-ascorbate radical + N-dodecanoyl-(2S)-hydroxyglycine => 2 L-ascorbate + N-dodecanoylglycine + O2"}
{"X":50054,"RHEA_ID":58543,"compounds":"2 L-ascorbate + N-dodecanoylglycine + O2 <=> H2O + 2 monodehydro-L-ascorbate radical + N-dodecanoyl-(2S)-hydroxyglycine"}
{"X":50055,"RHEA_ID":48518,"compounds":"dodecanoate + dodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) => 1,2-didodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O"}
{"X":50056,"RHEA_ID":48519,"compounds":"1,2-didodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O <=> dodecanoate + dodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+)"}
{"X":50057,"RHEA_ID":48520,"DIRECTION":"UN","MASTER_ID":48520,"ec":"3.1.1.n2","compounds":"[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + H2O = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + H(+) + methanol"}
{"X":50058,"RHEA_ID":58547,"compounds":"2 L-ascorbate + N-tetradecanoylglycine + O2 <=> H2O + 2 monodehydro-L-ascorbate radical + N-tetradecanoyl-(2S)-hydroxyglycine"}
{"X":50059,"RHEA_ID":48522,"compounds":"[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + H(+) + methanol => [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + H2O"}
{"X":50060,"RHEA_ID":58549,"compounds":"2 L-ascorbate + N-(9Z,12Z,15Z)-octadecatrienoylglycine + O2 => H2O + 2 monodehydro-L-ascorbate radical + N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine"}
{"X":50061,"RHEA_ID":48524,"compounds":"ganglioside GP1c + H2O = ganglioside GQ1c + N-acetylneuraminate"}
{"X":50062,"RHEA_ID":48525,"compounds":"ganglioside GP1c + H2O => ganglioside GQ1c + N-acetylneuraminate"}
{"X":50063,"RHEA_ID":48526,"compounds":"ganglioside GQ1c + N-acetylneuraminate => ganglioside GP1c + H2O"}
{"X":50064,"RHEA_ID":58553,"compounds":"15alpha-stemmadenine intermediate II + H2O => (16R)-deshydroxymethyl-stemmadenine + formate"}
{"X":50065,"RHEA_ID":48528,"compounds":"ganglioside GP1c (d18:1(4E)) + H2O = ganglioside GQ1c (d18:1(4E)) + N-acetylneuraminate"}
{"X":50066,"RHEA_ID":58555,"compounds":"15alpha-stemmadenine intermediate II + H2O <=> (16R)-deshydroxymethyl-stemmadenine + formate"}
{"X":50067,"RHEA_ID":48530,"compounds":"ganglioside GQ1c (d18:1(4E)) + N-acetylneuraminate => ganglioside GP1c (d18:1(4E)) + H2O"}
{"X":50068,"RHEA_ID":48531,"compounds":"ganglioside GP1c (d18:1(4E)) + H2O <=> ganglioside GQ1c (d18:1(4E)) + N-acetylneuraminate"}
{"X":50069,"RHEA_ID":48532,"compounds":"ganglioside GQ1c (d18:1(4E)) + H2O = ganglioside GT1c (d18:1(4E)) + N-acetylneuraminate"}
{"X":50070,"RHEA_ID":58559,"compounds":"15alpha-stemmadenine intermediate II + H2O <=> (16S)-deshydroxymethyl-stemmadenine + formate"}
{"X":50071,"RHEA_ID":48534,"compounds":"ganglioside GT1c (d18:1(4E)) + N-acetylneuraminate => ganglioside GQ1c (d18:1(4E)) + H2O"}
{"X":50072,"RHEA_ID":48535,"compounds":"ganglioside GQ1c (d18:1(4E)) + H2O <=> ganglioside GT1c (d18:1(4E)) + N-acetylneuraminate"}
{"X":50073,"RHEA_ID":48536,"compounds":"1-beta-D-galactosyl-2,3-didodecanoyl-sn-glycerol + H2O = 1-beta-D-galactosyl-dodecanoyl-sn-glycerol + dodecanoate + H(+)"}
{"X":50074,"RHEA_ID":48537,"compounds":"1-beta-D-galactosyl-2,3-didodecanoyl-sn-glycerol + H2O => 1-beta-D-galactosyl-dodecanoyl-sn-glycerol + dodecanoate + H(+)"}
{"X":50075,"RHEA_ID":51907,"compounds":"10-formyltetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate <=> 10-formyltetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate"}
{"X":50076,"RHEA_ID":48539,"compounds":"1-beta-D-galactosyl-2,3-didodecanoyl-sn-glycerol + H2O <=> 1-beta-D-galactosyl-dodecanoyl-sn-glycerol + dodecanoate + H(+)"}
{"X":50077,"RHEA_ID":48540,"compounds":"1,2-didodecanoyl-3-beta-D-galactosyl-sn-glycerol + H2O = dodecanoate + dodecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+)"}
{"X":50078,"RHEA_ID":48541,"compounds":"1,2-didodecanoyl-3-beta-D-galactosyl-sn-glycerol + H2O => dodecanoate + dodecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+)"}
{"X":50079,"RHEA_ID":51911,"compounds":"dATP + H2O <=> dADP + H(+) + phosphate"}
{"X":50080,"RHEA_ID":58569,"DIRECTION":"LR","MASTER_ID":58568,"metacyc":"RXN-19971","compounds":"15alpha-stemmadenine + acetyl-CoA => CoA + O-acetyl-15alpha-stemmadenine"}
{"X":50081,"RHEA_ID":48544,"DIRECTION":"UN","MASTER_ID":48544,"ec":"2.1.1.233","compounds":"[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine"}
{"X":50082,"RHEA_ID":48545,"DIRECTION":"LR","MASTER_ID":48544,"metacyc":"RXN-12317","compounds":"[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine => [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine"}
{"X":50083,"RHEA_ID":48546,"compounds":"[phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine => [phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine"}
{"X":50084,"RHEA_ID":48547,"compounds":"[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine <=> [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine"}
{"X":50085,"RHEA_ID":48548,"DIRECTION":"UN","MASTER_ID":48548,"ec":"3.1.1.89","compounds":"[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + H(+) + methanol"}
{"X":50086,"RHEA_ID":48549,"DIRECTION":"LR","MASTER_ID":48548,"metacyc":"RXN-12322","compounds":"[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O => [phosphatase 2A protein]-C-terminal L-leucine + H(+) + methanol"}
{"X":50087,"RHEA_ID":58575,"compounds":"O-acetyl-15alpha-stemmadenine + O2 <=> H2O2 + precondylocarpine acetate"}
{"X":50088,"RHEA_ID":58577,"compounds":"dihydroprecondylocarpine acetate + NADP(+) => H(+) + NADPH + precondylocarpine acetate"}
{"X":50089,"RHEA_ID":58578,"DIRECTION":"RL","MASTER_ID":58576,"metacyc":"RXN-19978","compounds":"H(+) + NADPH + precondylocarpine acetate => dihydroprecondylocarpine acetate + NADP(+)"}
{"X":50090,"RHEA_ID":48553,"compounds":"1-(9S,13S-12-oxo-10,15Z-phytodienoyl)-2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O => (10Z,15Z)-12-oxophytodienoate + 2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+)"}
{"X":50091,"RHEA_ID":58580,"compounds":"dihydroprecondylocarpine acetate = acetate + catharanthine + H(+)"}
{"X":50092,"RHEA_ID":48555,"compounds":"1-(9S,13S-12-oxo-10,15Z-phytodienoyl)-2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O <=> (10Z,15Z)-12-oxophytodienoate + 2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+)"}
{"X":50093,"RHEA_ID":48556,"DIRECTION":"UN","MASTER_ID":48556,"ec":"2.4.2.54","compounds":"4-hydroxybenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) = 4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate"}
{"X":50094,"RHEA_ID":48557,"DIRECTION":"LR","MASTER_ID":48556,"metacyc":"RXN-8124","compounds":"4-hydroxybenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) => 4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate"}
{"X":50095,"RHEA_ID":58584,"compounds":"dihydroprecondylocarpine acetate = (-)-tabersonine + acetate + H(+)"}
{"X":50096,"RHEA_ID":49685,"DIRECTION":"LR","MASTER_ID":49684,"metacyc":"RXN-17558","compounds":"H(+) + NADH + O2 + resorcinol => benzene-1,2,4-triol + H2O + NAD(+)"}
{"X":50097,"RHEA_ID":48560,"DIRECTION":"UN","MASTER_ID":48560,"ec":"3.2.2.n1","compounds":"H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate = D-ribose 5-phosphate + N(6)-dimethylallyladenine"}
{"X":50098,"RHEA_ID":48561,"DIRECTION":"LR","MASTER_ID":48560,"metacyc":"RXN-4313","compounds":"H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate => D-ribose 5-phosphate + N(6)-dimethylallyladenine"}
{"X":50099,"RHEA_ID":58588,"compounds":"dihydroprecondylocarpine acetate + NADPH = (+)-vincadifformine + acetate + NADP(+)"}
{"X":50100,"RHEA_ID":58589,"compounds":"dihydroprecondylocarpine acetate + NADPH => (+)-vincadifformine + acetate + NADP(+)"}
{"X":50101,"RHEA_ID":48564,"DIRECTION":"UN","MASTER_ID":48564,"ec":"3.2.2.n1","compounds":"9-ribosyl-trans-zeatin 5'-phosphate + H2O = D-ribose 5-phosphate + trans-zeatin"}
{"X":50102,"RHEA_ID":48565,"DIRECTION":"LR","MASTER_ID":48564,"metacyc":"RXN-4314","compounds":"9-ribosyl-trans-zeatin 5'-phosphate + H2O => D-ribose 5-phosphate + trans-zeatin"}
{"X":50103,"RHEA_ID":58593,"compounds":"1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH => 1-hexadecanoyl-2-(9-hydroxynonanoyl)-sn-glycero-3-phosphocholine + NADP(+)"}
{"X":50104,"RHEA_ID":48568,"compounds":"3-chlorocatechol + O2 = (2E,4Z)-2-chloromuconate + 2 H(+)"}
{"X":50105,"RHEA_ID":48569,"DIRECTION":"LR","MASTER_ID":48568,"metacyc":"RXN-9860","compounds":"3-chlorocatechol + O2 => (2E,4Z)-2-chloromuconate + 2 H(+)"}
{"X":50106,"RHEA_ID":58600,"compounds":"2 L-ascorbate + N-(9Z-octadecenoyl)glycine + O2 = H2O + 2 monodehydro-L-ascorbate radical + N-(9Z-octadecenoyl)-(2S)-hydroxyglycine"}
{"X":50107,"RHEA_ID":58601,"compounds":"2 L-ascorbate + N-(9Z-octadecenoyl)glycine + O2 => H2O + 2 monodehydro-L-ascorbate radical + N-(9Z-octadecenoyl)-(2S)-hydroxyglycine"}
{"X":50108,"RHEA_ID":51941,"DIRECTION":"LR","MASTER_ID":51940,"metacyc":"RXN-9640","compounds":"(1E,2S)-2-methylbutanal oxime => (1Z,2S)-2-methylbutanal oxime"}
{"X":50109,"RHEA_ID":48573,"DIRECTION":"LR","MASTER_ID":48572,"metacyc":"RXN-9855","compounds":"3,5-dichlorocatechol + O2 => (2E,4E)-2,4-dichloromuconate + 2 H(+)"}
{"X":50110,"RHEA_ID":62312,"compounds":"salicylate + UDP-alpha-D-glucose = H(+) + salicylate 2-O-beta-D-glucoside + UDP"}
{"X":50111,"RHEA_ID":58605,"compounds":"FAD + 2 H(+) + NADH + O2 => FADH2-C4alpha-hydroperoxide + NAD(+)"}
{"X":50112,"RHEA_ID":58606,"compounds":"FADH2-C4alpha-hydroperoxide + NAD(+) => FAD + 2 H(+) + NADH + O2"}
{"X":50113,"RHEA_ID":48577,"DIRECTION":"LR","MASTER_ID":48576,"metacyc":"RXN-9870","compounds":"4-chlorocatechol + O2 => 3-chloro-cis,cis-muconate + 2 H(+)"}
{"X":50114,"RHEA_ID":58608,"compounds":"2 L-ascorbate + N-decanoylglycine + O2 = H2O + 2 monodehydro-L-ascorbate radical + N-decanoyl-(2S)-hydroxyglycine"}
{"X":50115,"RHEA_ID":58609,"compounds":"2 L-ascorbate + N-decanoylglycine + O2 => H2O + 2 monodehydro-L-ascorbate radical + N-decanoyl-(2S)-hydroxyglycine"}
{"X":50116,"RHEA_ID":48580,"DIRECTION":"UN","MASTER_ID":48580,"ec":"2.7.4.28","compounds":"[pyruvate, water dikinase]-phosphate + H(+) + phosphate = [pyruvate, water dikinase] + diphosphate"}
{"X":50117,"RHEA_ID":48581,"compounds":"[pyruvate, water dikinase]-phosphate + H(+) + phosphate => [pyruvate, water dikinase] + diphosphate"}
{"X":50118,"RHEA_ID":58612,"compounds":"2 L-ascorbate + N-octanoylglycine + O2 = H2O + 2 monodehydro-L-ascorbate radical + N-octanoyl-(2S)-hydroxyglycine"}
{"X":50119,"RHEA_ID":48583,"DIRECTION":"BI","MASTER_ID":48580,"metacyc":"RXN-13759","compounds":"[pyruvate, water dikinase]-phosphate + H(+) + phosphate <=> [pyruvate, water dikinase] + diphosphate"}
{"X":50120,"RHEA_ID":48584,"compounds":"2 H2O + 2 leukotriene A4 + O2 = 2 lipoxin A4"}
{"X":50121,"RHEA_ID":48585,"compounds":"2 H2O + 2 leukotriene A4 + O2 => 2 lipoxin A4"}
{"X":50122,"RHEA_ID":58616,"compounds":"N-octanoyl-(2S)-hydroxyglycine = glyoxylate + octanamide"}
{"X":50123,"RHEA_ID":48587,"compounds":"2 H2O + 2 leukotriene A4 + O2 <=> 2 lipoxin A4"}
{"X":50124,"RHEA_ID":51957,"DIRECTION":"LR","MASTER_ID":51956,"metacyc":"RXN-5066","compounds":"(E)-2-methylpropanal oxime => (Z)-2-methylpropanal oxime"}
{"X":50125,"RHEA_ID":48589,"compounds":"2 H2O + 2 leukotriene A4 + O2 => 2 lipoxin B4"}
{"X":50126,"RHEA_ID":48590,"compounds":"2 lipoxin B4 => 2 H2O + 2 leukotriene A4 + O2"}
{"X":50127,"RHEA_ID":48591,"compounds":"2 H2O + 2 leukotriene A4 + O2 <=> 2 lipoxin B4"}
{"X":50128,"RHEA_ID":48592,"DIRECTION":"UN","MASTER_ID":48592,"ec":"1.17.5.3","compounds":"a quinone + formate + H(+) = a quinol + CO2"}
{"X":50129,"RHEA_ID":48593,"compounds":"a quinone + formate + H(+) => a quinol + CO2"}
{"X":50130,"RHEA_ID":58624,"compounds":"N-dodecanoyl-(2S)-hydroxyglycine = dodecanamide + glyoxylate"}
{"X":50131,"RHEA_ID":48596,"compounds":"1,2-didecanoylglycerol + H2O = decanoate + decanoylglycerol + H(+)"}
{"X":50132,"RHEA_ID":48597,"compounds":"1,2-didecanoylglycerol + H2O => decanoate + decanoylglycerol + H(+)"}
{"X":50133,"RHEA_ID":48598,"compounds":"decanoate + decanoylglycerol + H(+) => 1,2-didecanoylglycerol + H2O"}
{"X":50134,"RHEA_ID":48599,"compounds":"1,2-didecanoylglycerol + H2O <=> decanoate + decanoylglycerol + H(+)"}
{"X":50135,"RHEA_ID":48600,"compounds":"[protein-PII]-uridylyl-L-tyrosine + H2O = [protein-PII]-L-tyrosine + H(+) + UMP"}
{"X":50136,"RHEA_ID":48601,"DIRECTION":"LR","MASTER_ID":48600,"ecocyc":"RXN-16381","metacyc":"RXN-16381","compounds":"[protein-PII]-uridylyl-L-tyrosine + H2O => [protein-PII]-L-tyrosine + H(+) + UMP"}
{"X":50137,"RHEA_ID":58632,"compounds":"N-tetradecanoyl-(2S)-hydroxyglycine = glyoxylate + tetradecamide"}
{"X":50138,"RHEA_ID":48603,"compounds":"[protein-PII]-uridylyl-L-tyrosine + H2O <=> [protein-PII]-L-tyrosine + H(+) + UMP"}
{"X":50139,"RHEA_ID":48604,"compounds":"2,3-dihydroxybenzoyl-5'-AMP + holo-[EntB isochorismatase/aryl-carrier protein] = 2,3-dihydroxybenzoyl-[EntB isochorismatase/aryl-carrier protein] + AMP + H(+)"}
{"X":50140,"RHEA_ID":48605,"DIRECTION":"LR","MASTER_ID":48604,"ecocyc":"RXN0-6442","metacyc":"RXN0-6442","compounds":"2,3-dihydroxybenzoyl-5'-AMP + holo-[EntB isochorismatase/aryl-carrier protein] => 2,3-dihydroxybenzoyl-[EntB isochorismatase/aryl-carrier protein] + AMP + H(+)"}
{"X":50141,"RHEA_ID":58636,"compounds":"N-(9Z-octadecenoyl)-(2S)-hydroxyglycine = (9Z)-octadecenamide + glyoxylate"}
{"X":50142,"RHEA_ID":48607,"compounds":"2,3-dihydroxybenzoyl-5'-AMP + holo-[EntB isochorismatase/aryl-carrier protein] <=> 2,3-dihydroxybenzoyl-[EntB isochorismatase/aryl-carrier protein] + AMP + H(+)"}
{"X":50143,"RHEA_ID":48608,"compounds":"A + a 2,3-saturated acyl-CoA = a 2,3-dehydroacyl-CoA + AH2"}
{"X":50144,"RHEA_ID":48609,"compounds":"A + a 2,3-saturated acyl-CoA => a 2,3-dehydroacyl-CoA + AH2"}
{"X":50145,"RHEA_ID":58640,"compounds":"a 5'-(5'-phospho)-ribonucleoside-RNA + 2 S-adenosyl-L-methionine = a 5'-(5'-bisphosphomethyl)-ribonucleoside-RNA + 2 S-adenosyl-L-homocysteine"}
{"X":50146,"RHEA_ID":48611,"compounds":"A + a 2,3-saturated acyl-CoA <=> a 2,3-dehydroacyl-CoA + AH2"}
{"X":50147,"RHEA_ID":48612,"DIRECTION":"UN","MASTER_ID":48612,"ec":"2.8.1.11","compounds":"[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]"}
{"X":50148,"RHEA_ID":48613,"DIRECTION":"LR","MASTER_ID":48612,"ecocyc":"RXN-12473","metacyc":"RXN-12473","compounds":"[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] => [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]"}
{"X":50149,"RHEA_ID":48614,"compounds":"[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase] => [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase]"}
{"X":50150,"RHEA_ID":48615,"compounds":"[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] <=> [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]"}
{"X":50151,"RHEA_ID":48616,"compounds":"H2O + leukotriene D4 = glycine + leukotriene E4"}
{"X":50152,"RHEA_ID":48617,"DIRECTION":"LR","MASTER_ID":48616,"metacyc":"RXN66-337","reactome":"R-HSA-266012.2","compounds":"H2O + leukotriene D4 => glycine + leukotriene E4"}
{"X":50153,"RHEA_ID":58648,"compounds":"rifamycin SV hemiaminal = H(+) + rifamycin SV ortho-naphthoquinone carboxamide"}
{"X":50154,"RHEA_ID":58649,"compounds":"rifamycin SV hemiaminal => H(+) + rifamycin SV ortho-naphthoquinone carboxamide"}
{"X":50155,"RHEA_ID":48620,"compounds":"(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O"}
{"X":50156,"RHEA_ID":48621,"DIRECTION":"LR","MASTER_ID":48620,"reactome":"R-HSA-2161946.2","compounds":"(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione => (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O"}
{"X":50157,"RHEA_ID":58652,"compounds":"rifamycin SV ortho-naphthoquinone carboxamide = rifamycin SV para-naphthoquinone carboxamide"}
{"X":50158,"RHEA_ID":48623,"compounds":"(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione <=> (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O"}
{"X":50159,"RHEA_ID":48624,"compounds":"(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + O2 = (5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate"}
{"X":50160,"RHEA_ID":48625,"compounds":"(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + O2 => (5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate"}
{"X":50161,"RHEA_ID":58656,"compounds":"a 5'-(5'-phospho)-ribonucleoside-RNA + S-adenosyl-L-methionine = a 5'-(5'-phosphomethyl)-ribonucleoside-RNA + S-adenosyl-L-homocysteine"}
{"X":50162,"RHEA_ID":48627,"compounds":"(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + O2 <=> (5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate"}
{"X":50163,"RHEA_ID":48628,"compounds":"a ribonucleotide in rRNA + S-adenosyl-L-methionine = a 2'-O-methylribonucleotide in rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":50164,"RHEA_ID":48629,"compounds":"a ribonucleotide in rRNA + S-adenosyl-L-methionine => a 2'-O-methylribonucleotide in rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":50165,"RHEA_ID":58660,"compounds":"a 5'-(5'-phosphomethyl)-ribonucleoside-RNA + S-adenosyl-L-methionine = a 5'-(5'-bisphosphomethyl)-ribonucleoside-RNA + S-adenosyl-L-homocysteine"}
{"X":50166,"RHEA_ID":48631,"compounds":"a ribonucleotide in rRNA + S-adenosyl-L-methionine <=> a 2'-O-methylribonucleotide in rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":50167,"RHEA_ID":48632,"compounds":"(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = 5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoate + H2O"}
{"X":50168,"RHEA_ID":48633,"compounds":"(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate => 5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoate + H2O"}
{"X":50169,"RHEA_ID":58664,"DIRECTION":"UN","MASTER_ID":58664,"ec":"1.1.5.13","compounds":"(S)-2-hydroxyglutarate + a quinone = 2-oxoglutarate + a quinol"}
{"X":50170,"RHEA_ID":48635,"compounds":"(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate <=> 5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoate + H2O"}
{"X":50171,"RHEA_ID":48636,"compounds":"(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O"}
{"X":50172,"RHEA_ID":48637,"compounds":"(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O"}
{"X":50173,"RHEA_ID":58668,"compounds":"3-deoxyfructose + NADP(+) = 3-deoxyglucosone + H(+) + NADPH"}
{"X":50174,"RHEA_ID":48639,"compounds":"(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate <=> 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O"}
{"X":50175,"RHEA_ID":48640,"compounds":"(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+) = 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + NADH"}
{"X":50176,"RHEA_ID":48641,"compounds":"(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+) => 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + NADH"}
{"X":50177,"RHEA_ID":48642,"compounds":"11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + NADH => (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+)"}
{"X":50178,"RHEA_ID":48643,"compounds":"(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+) <=> 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + NADH"}
{"X":50179,"RHEA_ID":48644,"compounds":"prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde"}
{"X":50180,"RHEA_ID":48645,"DIRECTION":"LR","MASTER_ID":48644,"reactome":"R-HSA-2161613.2","compounds":"prostaglandin H2 => (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde"}
{"X":50181,"RHEA_ID":48646,"compounds":"(12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde => prostaglandin H2"}
{"X":50182,"RHEA_ID":48647,"compounds":"prostaglandin H2 <=> (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde"}
{"X":50183,"RHEA_ID":48648,"compounds":"lipoxin A4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-lipoxin A4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50184,"RHEA_ID":48649,"compounds":"lipoxin A4 + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-lipoxin A4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50185,"RHEA_ID":48650,"compounds":"20-hydroxy-lipoxin A4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => lipoxin A4 + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":50186,"RHEA_ID":48651,"compounds":"lipoxin A4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-lipoxin A4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50187,"RHEA_ID":48652,"compounds":"lipoxin B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-lipoxin B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50188,"RHEA_ID":48653,"compounds":"lipoxin B4 + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-lipoxin B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50189,"RHEA_ID":58684,"compounds":"FAD + 2 H(+) + NADPH + O2 = FADH2-C4alpha-hydroperoxide + NADP(+)"}
{"X":50190,"RHEA_ID":48655,"compounds":"lipoxin B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-lipoxin B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50191,"RHEA_ID":48656,"compounds":"5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 5,20-dihydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50192,"RHEA_ID":48657,"compounds":"5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 5,20-dihydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50193,"RHEA_ID":48658,"compounds":"5,20-dihydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":50194,"RHEA_ID":58689,"compounds":"NADH + O2 + rifamycin SV => H2O + NAD(+) + rifamycin SV para-naphthoquinone carboxamide"}
{"X":50195,"RHEA_ID":48660,"compounds":"8-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 8,20-dihydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50196,"RHEA_ID":48661,"compounds":"8-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 8,20-dihydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50197,"RHEA_ID":48662,"compounds":"8,20-dihydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 8-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":50198,"RHEA_ID":58693,"compounds":"FADH2-C4alpha-hydroperoxide + H(+) + NADH + rifamycin SV => FADH2 + H2O + NAD(+) + rifamycin SV hemiaminal"}
{"X":50199,"RHEA_ID":48664,"compounds":"12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 12,20-dihydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50200,"RHEA_ID":48665,"compounds":"12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 12,20-dihydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50201,"RHEA_ID":48666,"compounds":"12,20-dihydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":50202,"RHEA_ID":48667,"compounds":"12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 12,20-dihydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50203,"RHEA_ID":58698,"compounds":"H(+) + H2O + NADP(+) + rifampicin para-naphthoquinone carboxamide => NADPH + O2 + rifampicin"}
{"X":50204,"RHEA_ID":48669,"compounds":"20-hydroxy-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] => 20-oxo-leukotriene B4 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50205,"RHEA_ID":48670,"compounds":"20-oxo-leukotriene B4 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 20-hydroxy-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":50206,"RHEA_ID":48671,"compounds":"20-hydroxy-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-oxo-leukotriene B4 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50207,"RHEA_ID":58702,"compounds":"FADH2 + H(+) + H2O + NADP(+) + rifampicin hemiaminal => FADH2-C4alpha-hydroperoxide + NADPH + rifampicin"}
{"X":50208,"RHEA_ID":48673,"compounds":"20-oxo-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] => 20-carboxy-leukotriene B4 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50209,"RHEA_ID":48674,"compounds":"20-carboxy-leukotriene B4 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 20-oxo-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":50210,"RHEA_ID":48675,"compounds":"20-oxo-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-carboxy-leukotriene B4 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50211,"RHEA_ID":58706,"compounds":"rifampicin ortho-naphthoquinone carboxamide => rifampicin hemiaminal"}
{"X":50212,"RHEA_ID":48677,"compounds":"6-trans-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-6-trans-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50213,"RHEA_ID":48678,"compounds":"20-hydroxy-6-trans-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 6-trans-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":50214,"RHEA_ID":48679,"compounds":"6-trans-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-6-trans-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50215,"RHEA_ID":58710,"compounds":"rifampicin para-naphthoquinone carboxamide => rifampicin ortho-naphthoquinone carboxamide"}
{"X":50216,"RHEA_ID":48681,"compounds":"a very-long-chain (3R)-hydroxyacyl-CoA + NADP(+) => a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH"}
{"X":50217,"RHEA_ID":48682,"DIRECTION":"RL","MASTER_ID":48680,"metacyc":"RXN-7698","compounds":"a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH => a very-long-chain (3R)-hydroxyacyl-CoA + NADP(+)"}
{"X":50218,"RHEA_ID":52057,"compounds":"12-hexadecanoyloxy-octadecanoate + H2O => 12-hydroxyoctadecanoate + H(+) + hexadecanoate"}
{"X":50219,"RHEA_ID":48685,"DIRECTION":"LR","MASTER_ID":48684,"metacyc":"RXN-5185","compounds":"[amino group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O => [amino group carrier protein]-C-terminal-L-glutamate + L-lysine"}
{"X":50220,"RHEA_ID":48686,"compounds":"[amino group carrier protein]-C-terminal-L-glutamate + L-lysine => [amino group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O"}
{"X":50221,"RHEA_ID":52061,"compounds":"12-(9Z-octadecenoyloxy)-octadecanoate + H2O => (9Z)-octadecenoate + 12-hydroxyoctadecanoate + H(+)"}
{"X":50222,"RHEA_ID":48689,"DIRECTION":"LR","MASTER_ID":48688,"metacyc":"3.4.17.13-RXN","compounds":"H2O + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanine => D-alanine + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl"}
{"X":50223,"RHEA_ID":48690,"compounds":"D-alanine + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl => H2O + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanine"}
{"X":50224,"RHEA_ID":48691,"compounds":"H2O + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanine <=> D-alanine + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl"}
{"X":50225,"RHEA_ID":58722,"compounds":"H2O + NADP(+) + trans-(S)-nicotine N(1')-oxide => (S)-nicotine + NADPH + O2"}
{"X":50226,"RHEA_ID":48693,"compounds":"1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O => H(+) + octanoate + octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol"}
{"X":50227,"RHEA_ID":48694,"compounds":"H(+) + octanoate + octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol => 1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O"}
{"X":50228,"RHEA_ID":48695,"compounds":"1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O <=> H(+) + octanoate + octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol"}
{"X":50229,"RHEA_ID":58726,"compounds":"H(+) + N(6)-methyladenosine(4220) in 28S rRNA + S-adenosyl-L-homocysteine => adenosine(4220) in 28S rRNA + S-adenosyl-L-methionine"}
{"X":50230,"RHEA_ID":58727,"compounds":"adenosine(4220) in 28S rRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine(4220) in 28S rRNA + S-adenosyl-L-homocysteine"}
{"X":50231,"RHEA_ID":48698,"compounds":"H(+) + octanoate + octanoyl-3-(beta-D-galactosyl)-sn-glycerol => 1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O"}
{"X":50232,"RHEA_ID":48699,"compounds":"1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O <=> H(+) + octanoate + octanoyl-3-(beta-D-galactosyl)-sn-glycerol"}
{"X":50233,"RHEA_ID":48700,"compounds":"H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol = a fatty acid + H(+) + long chain acyl-3-O-beta-D-galactosyl-sn-glycerol"}
{"X":50234,"RHEA_ID":58731,"compounds":"adenosine in rRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine in rRNA + S-adenosyl-L-homocysteine"}
{"X":50235,"RHEA_ID":48702,"compounds":"a fatty acid + H(+) + long chain acyl-3-O-beta-D-galactosyl-sn-glycerol => H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol"}
{"X":50236,"RHEA_ID":48703,"compounds":"H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol <=> a fatty acid + H(+) + long chain acyl-3-O-beta-D-galactosyl-sn-glycerol"}
{"X":50237,"RHEA_ID":58734,"compounds":"5-methyl-CMP + diphosphate + H(+) => 5-methyl-CTP + H2O"}
{"X":50238,"RHEA_ID":58735,"compounds":"5-methyl-CTP + H2O <=> 5-methyl-CMP + diphosphate + H(+)"}
{"X":50239,"RHEA_ID":48706,"compounds":"12S-HpEPE => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2"}
{"X":50240,"RHEA_ID":48707,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 <=> 12S-HpEPE"}
{"X":50241,"RHEA_ID":52081,"compounds":"12-octadecanoyloxy-octadecanoate + H2O => 12-hydroxyoctadecanoate + H(+) + octadecanoate"}
{"X":50242,"RHEA_ID":48709,"compounds":"H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol => a fatty acid + H(+) + long chain acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol"}
{"X":50243,"RHEA_ID":48710,"compounds":"a fatty acid + H(+) + long chain acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol => H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol"}
{"X":50244,"RHEA_ID":48711,"compounds":"H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol <=> a fatty acid + H(+) + long chain acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol"}
{"X":50245,"RHEA_ID":48712,"compounds":"2 Fe(2+) + 2 H(+) + H2O2 = 2 Fe(3+) + 2 H2O"}
{"X":50246,"RHEA_ID":48713,"compounds":"2 Fe(2+) + 2 H(+) + H2O2 => 2 Fe(3+) + 2 H2O"}
{"X":50247,"RHEA_ID":48714,"compounds":"2 Fe(3+) + 2 H2O => 2 Fe(2+) + 2 H(+) + H2O2"}
{"X":50248,"RHEA_ID":48715,"compounds":"2 Fe(2+) + 2 H(+) + H2O2 <=> 2 Fe(3+) + 2 H2O"}
{"X":50249,"RHEA_ID":58746,"compounds":"7-methyl-GMP + diphosphate + H(+) => 7-methyl-GTP + H2O"}
{"X":50250,"RHEA_ID":48717,"compounds":"(13S)-hydroperoxy-(9Z,11E)-octadecadienoate => 13-oxo-(9Z,11E)-octadecadienoate + H2O"}
{"X":50251,"RHEA_ID":48718,"compounds":"13-oxo-(9Z,11E)-octadecadienoate + H2O => (13S)-hydroperoxy-(9Z,11E)-octadecadienoate"}
{"X":50252,"RHEA_ID":48719,"compounds":"(13S)-hydroperoxy-(9Z,11E)-octadecadienoate <=> 13-oxo-(9Z,11E)-octadecadienoate + H2O"}
{"X":50253,"RHEA_ID":58750,"compounds":"H(+) + nectriapyrone + S-adenosyl-L-homocysteine => desmethylnectriapyrone + S-adenosyl-L-methionine"}
{"X":50254,"RHEA_ID":48721,"compounds":"aurachin B + H2O + NAD(+) => 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NADH"}
{"X":50255,"RHEA_ID":48722,"compounds":"4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NADH => aurachin B + H2O + NAD(+)"}
{"X":50256,"RHEA_ID":58753,"compounds":"1-hexadecanoyl-2-(7-oxoheptanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH => 1-hexadecanoyl-2-(7-hydroxyheptanoyl)-sn-glycero-3-phosphocholine + NADP(+)"}
{"X":50257,"RHEA_ID":48724,"compounds":"aurachin B + H(+) + H2O = 3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide"}
{"X":50258,"RHEA_ID":48725,"compounds":"aurachin B + H(+) + H2O => 3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide"}
{"X":50259,"RHEA_ID":48726,"DIRECTION":"RL","MASTER_ID":48724,"metacyc":"RXN-17336","compounds":"3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide => aurachin B + H(+) + H2O"}
{"X":50260,"RHEA_ID":58757,"compounds":"1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphoethanolamine + H(+) + NADPH => 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphoethanolamine + NADP(+)"}
{"X":50261,"RHEA_ID":58758,"compounds":"1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphoethanolamine + NADP(+) => 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphoethanolamine + H(+) + NADPH"}
{"X":50262,"RHEA_ID":48729,"compounds":"3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NAD(+) => 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H(+) + NADH"}
{"X":50263,"RHEA_ID":62572,"compounds":"H2O + S-(6-hydroxy-4-methylhexan-4-yl)-L-cysteinylglycine = glycine + S-(6-hydroxy-4-methylhexan-4-yl)-L-cysteine"}
{"X":50264,"RHEA_ID":58761,"compounds":"1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + NADPH => 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + NADP(+)"}
{"X":50265,"RHEA_ID":48732,"DIRECTION":"UN","MASTER_ID":48732,"ec":"3.13.1.6","compounds":"[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + H2O = [CysO sulfur-carrier protein]-C-terminal Gly-Gly + H(+) + L-cysteine"}
{"X":50266,"RHEA_ID":62575,"compounds":"H2O + S-(6-hydroxy-4-methylhexan-4-yl)-L-cysteinylglycine <=> glycine + S-(6-hydroxy-4-methylhexan-4-yl)-L-cysteine"}
{"X":50267,"RHEA_ID":62576,"DIRECTION":"UN","MASTER_ID":62576,"ec":"7.4.2.12","compounds":"ATP + H2O + L-cystine(out) = ADP + H(+) + L-cystine(in) + phosphate"}
{"X":50268,"RHEA_ID":48735,"compounds":"[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + H2O <=> [CysO sulfur-carrier protein]-C-terminal Gly-Gly + H(+) + L-cysteine"}
{"X":50269,"RHEA_ID":48736,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50270,"RHEA_ID":58767,"compounds":"1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphate + H(+) + NADPH <=> 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphate + NADP(+)"}
{"X":50271,"RHEA_ID":52111,"compounds":"5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA <=> 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate"}
{"X":50272,"RHEA_ID":48739,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50273,"RHEA_ID":48740,"DIRECTION":"UN","MASTER_ID":48740,"ec":"2.5.1.113","compounds":"[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + O-phospho-L-serine = [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + phosphate"}
{"X":50274,"RHEA_ID":58771,"compounds":"1-O-(1Z-hexadecenyl)-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH <=> 1-O-(1Z-hexadecenyl)-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)"}
{"X":50275,"RHEA_ID":48742,"compounds":"[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + phosphate => [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + O-phospho-L-serine"}
{"X":50276,"RHEA_ID":48744,"DIRECTION":"UN","MASTER_ID":48744,"ec":"1.14.20.8","compounds":"(-)-yatein + 2-oxoglutarate + O2 = (-)-deoxypodophyllotoxin + CO2 + H2O + succinate"}
{"X":50277,"RHEA_ID":58775,"compounds":"1-O-hexadecyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH <=> 1-O-hexadecyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)"}
{"X":50278,"RHEA_ID":62588,"compounds":"2-hydroxy-2-(4-hydroxyphenyl)acetate + H(+) = 4-hydroxybenzyl alcohol + CO2"}
{"X":50279,"RHEA_ID":58777,"compounds":"NADP(+) + pyridine 3-methanol => H(+) + NADPH + pyridine-3-carbaldehyde"}
{"X":50280,"RHEA_ID":58778,"compounds":"H(+) + NADPH + pyridine-3-carbaldehyde => NADP(+) + pyridine 3-methanol"}
{"X":50281,"RHEA_ID":58779,"compounds":"NADP(+) + pyridine 3-methanol <=> H(+) + NADPH + pyridine-3-carbaldehyde"}
{"X":50282,"RHEA_ID":48750,"compounds":"D-erythrulose + H(+) + NADH => D-threitol + NAD(+)"}
{"X":50283,"RHEA_ID":48751,"DIRECTION":"BI","MASTER_ID":48748,"metacyc":"ERYTHRULOSE-REDUCTASE-RXN","compounds":"D-threitol + NAD(+) <=> D-erythrulose + H(+) + NADH"}
{"X":50284,"RHEA_ID":48752,"DIRECTION":"UN","MASTER_ID":48752,"ec":"1.14.11.52","compounds":"2-oxoglutarate + O2 + validamycin A = CO2 + H(+) + succinate + validamycin B"}
{"X":50285,"RHEA_ID":58783,"compounds":"a 5'-triphospho-guanosine-ribonucleotide-snRNA + S-adenosyl-L-methionine <=> a 5'-methyltriphosphate-guanosine-ribonucleotide-snRNA + S-adenosyl-L-homocysteine"}
{"X":50286,"RHEA_ID":48754,"compounds":"CO2 + H(+) + succinate + validamycin B => 2-oxoglutarate + O2 + validamycin A"}
{"X":50287,"RHEA_ID":58785,"compounds":"2-oxoglutarate + a 5'-methyltriphosphate-guanosine-ribonucleotide-snRNA + O2 => a 5'-triphospho-guanosine-ribonucleotide-snRNA + CO2 + formaldehyde + H(+) + succinate"}
{"X":50288,"RHEA_ID":58786,"compounds":"a 5'-triphospho-guanosine-ribonucleotide-snRNA + CO2 + formaldehyde + H(+) + succinate => 2-oxoglutarate + a 5'-methyltriphosphate-guanosine-ribonucleotide-snRNA + O2"}
{"X":50289,"RHEA_ID":58787,"compounds":"2-oxoglutarate + a 5'-methyltriphosphate-guanosine-ribonucleotide-snRNA + O2 <=> a 5'-triphospho-guanosine-ribonucleotide-snRNA + CO2 + formaldehyde + H(+) + succinate"}
{"X":50290,"RHEA_ID":48758,"compounds":"D-erythrulose + H(+) + NADH => erythritol + NAD(+)"}
{"X":50291,"RHEA_ID":48759,"DIRECTION":"BI","MASTER_ID":48756,"metacyc":"RXN-17763","compounds":"erythritol + NAD(+) <=> D-erythrulose + H(+) + NADH"}
{"X":50292,"RHEA_ID":48760,"compounds":"L-threitol + NAD(+) = H(+) + L-erythrulose + NADH"}
{"X":50293,"RHEA_ID":48761,"compounds":"L-threitol + NAD(+) => H(+) + L-erythrulose + NADH"}
{"X":50294,"RHEA_ID":48762,"compounds":"H(+) + L-erythrulose + NADH => L-threitol + NAD(+)"}
{"X":50295,"RHEA_ID":48763,"DIRECTION":"BI","MASTER_ID":48760,"metacyc":"RXN-17764","compounds":"L-threitol + NAD(+) <=> H(+) + L-erythrulose + NADH"}
{"X":50296,"RHEA_ID":48764,"DIRECTION":"UN","MASTER_ID":48764,"ec":"1.1.1.396","compounds":"3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + NAD(+) = 3-acetyl-3-devinylchlorophyllide a + H(+) + NADH"}
{"X":50297,"RHEA_ID":58799,"compounds":"a flavonol 7-O-beta-D-glucoside + malonyl-CoA <=> a flavonol 7-O-(6-O-malonyl-beta-D-glucoside) + CoA"}
{"X":50298,"RHEA_ID":58800,"compounds":"3',3'-cGAMP + H2O = 5'-pApG-3' + H(+)"}
{"X":50299,"RHEA_ID":48767,"compounds":"3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + NAD(+) <=> 3-acetyl-3-devinylchlorophyllide a + H(+) + NADH"}
{"X":50300,"RHEA_ID":48768,"DIRECTION":"UN","MASTER_ID":48768,"ec":"2.7.1.210","compounds":"ATP + D-erythrulose = ADP + D-erythrulose 4-phosphate + H(+)"}
{"X":50301,"RHEA_ID":48769,"DIRECTION":"LR","MASTER_ID":48768,"metacyc":"RXN-17761","compounds":"ATP + D-erythrulose => ADP + D-erythrulose 4-phosphate + H(+)"}
{"X":50302,"RHEA_ID":52143,"compounds":"(DNA)-3'-diphospho-5'-guanosine + H2O <=> (DNA)-3'-phosphate + GMP + 2 H(+)"}
{"X":50303,"RHEA_ID":48771,"compounds":"ATP + D-erythrulose <=> ADP + D-erythrulose 4-phosphate + H(+)"}
{"X":50304,"RHEA_ID":48772,"DIRECTION":"UN","MASTER_ID":48772,"ec":"4.2.1.165","compounds":"3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a = 3-deacetyl-3-vinylbacteriochlorophyllide a + H2O"}
{"X":50305,"RHEA_ID":48773,"compounds":"3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a => 3-deacetyl-3-vinylbacteriochlorophyllide a + H2O"}
{"X":50306,"RHEA_ID":58808,"compounds":"2',3'-cGAMP + 2 H2O = AMP + GMP + 2 H(+)"}
{"X":50307,"RHEA_ID":58809,"compounds":"2',3'-cGAMP + 2 H2O => AMP + GMP + 2 H(+)"}
{"X":50308,"RHEA_ID":48776,"compounds":"O2 + prostaglandin H2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxyprostaglandin H2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50309,"RHEA_ID":48777,"compounds":"O2 + prostaglandin H2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxyprostaglandin H2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50310,"RHEA_ID":48778,"compounds":"19-hydroxyprostaglandin H2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + prostaglandin H2 + reduced [NADPH--hemoprotein reductase]"}
{"X":50311,"RHEA_ID":48779,"compounds":"O2 + prostaglandin H2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxyprostaglandin H2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50312,"RHEA_ID":62646,"compounds":"(5S)-hydroperoxy-(6E,8Z)-eicosadienoate => (5Z,8Z)-eicosadienoate + O2"}
{"X":50313,"RHEA_ID":48781,"DIRECTION":"LR","MASTER_ID":48780,"metacyc":"RXN-17765","compounds":"ATP + L-erythrulose => ADP + H(+) + L-erythrulose 1-phosphate"}
{"X":50314,"RHEA_ID":58815,"compounds":"ATP + H2O + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate <=> AMP + diphosphate + H(+) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate"}
{"X":50315,"RHEA_ID":58817,"DIRECTION":"LR","MASTER_ID":58816,"metacyc":"RXN-19251","compounds":"ATP + L-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate"}
{"X":50316,"RHEA_ID":48784,"DIRECTION":"UN","MASTER_ID":48784,"ec":"5.3.1.34","compounds":"D-erythrulose 4-phosphate = D-erythrose 4-phosphate"}
{"X":50317,"RHEA_ID":48785,"compounds":"D-erythrulose 4-phosphate => D-erythrose 4-phosphate"}
{"X":50318,"RHEA_ID":58820,"DIRECTION":"UN","MASTER_ID":58820,"ec":"7.2.4.4","compounds":"H(+) + malonate + Na(+)(in) = acetate + CO2 + Na(+)(out)"}
{"X":50319,"RHEA_ID":58821,"DIRECTION":"LR","MASTER_ID":58820,"metacyc":"RXN-9774","compounds":"H(+) + malonate + Na(+)(in) => acetate + CO2 + Na(+)(out)"}
{"X":50320,"RHEA_ID":48792,"compounds":"GDP-beta-L-fucose + Lc4Cer = alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)"}
{"X":50321,"RHEA_ID":48793,"compounds":"GDP-beta-L-fucose + Lc4Cer => alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)"}
{"X":50322,"RHEA_ID":58824,"DIRECTION":"UN","MASTER_ID":58824,"ec":"1.14.15.37","compounds":"4 H(+) + luteothin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = aureothin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":50323,"RHEA_ID":48795,"compounds":"GDP-beta-L-fucose + Lc4Cer <=> alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)"}
{"X":50324,"RHEA_ID":48796,"compounds":"O2 + prostaglandin H1 + reduced [NADPH--hemoprotein reductase] = 19-hydroxyprostaglandin H1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50325,"RHEA_ID":52166,"compounds":"(R)-mandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + phenylacetonitrile + reduced [NADPH--hemoprotein reductase]"}
{"X":50326,"RHEA_ID":58828,"compounds":"(9S,10R)-epoxy-octadecanoate + H2O = 9R,10R-dihydroxyoctadecanoate"}
{"X":50327,"RHEA_ID":48799,"compounds":"O2 + prostaglandin H1 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxyprostaglandin H1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50328,"RHEA_ID":48800,"compounds":"a neolactoside nLc4Cer + GDP-beta-L-fucose = a neolactoside IV(2)-alpha-Fuc-nLc4Cer + GDP + H(+)"}
{"X":50329,"RHEA_ID":52170,"compounds":"8,9-epoxy-(5Z,11Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":50330,"RHEA_ID":58832,"DIRECTION":"UN","MASTER_ID":58832,"ec":"1.14.18.10","compounds":"24-methylenecycloartanol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}
{"X":50331,"RHEA_ID":48803,"compounds":"a neolactoside nLc4Cer + GDP-beta-L-fucose <=> a neolactoside IV(2)-alpha-Fuc-nLc4Cer + GDP + H(+)"}
{"X":50332,"RHEA_ID":48804,"compounds":"(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O"}
{"X":50333,"RHEA_ID":52174,"compounds":"11,12-epoxy-(5Z,8Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":50334,"RHEA_ID":58836,"compounds":"24-methylenecycloartanol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":50335,"RHEA_ID":48807,"compounds":"(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 <=> (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O"}
{"X":50336,"RHEA_ID":58838,"compounds":"4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O => 24-methylenecycloartanol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}
{"X":50337,"RHEA_ID":48809,"compounds":"(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 => (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O"}
{"X":50338,"RHEA_ID":58840,"compounds":"cholesterol sulfate + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-hydroxycholesterol 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50339,"RHEA_ID":48811,"compounds":"(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 <=> (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O"}
{"X":50340,"RHEA_ID":48812,"compounds":"(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O"}
{"X":50341,"RHEA_ID":52182,"compounds":"(E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (E)-(indol-3-yl)acetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":50342,"RHEA_ID":58844,"compounds":"(6E)-8-hydroxygeranial + NAD(+) = (6E)-8-oxogeranial + H(+) + NADH"}
{"X":50343,"RHEA_ID":48815,"compounds":"(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 <=> (5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O"}
{"X":50344,"RHEA_ID":48816,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O"}
{"X":50345,"RHEA_ID":52186,"compounds":"1-aci-nitro-2-(1H-indol-3-yl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (E)-(indol-3-yl)acetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":50346,"RHEA_ID":58848,"compounds":"(6E)-8-hydroxygeraniol + NAD(+) = (6E)-8-hydroxygeranial + H(+) + NADH"}
{"X":50347,"RHEA_ID":58849,"compounds":"(6E)-8-hydroxygeraniol + NAD(+) => (6E)-8-hydroxygeranial + H(+) + NADH"}
{"X":50348,"RHEA_ID":58850,"compounds":"(6E)-8-hydroxygeranial + H(+) + NADH => (6E)-8-hydroxygeraniol + NAD(+)"}
{"X":50349,"RHEA_ID":52190,"compounds":"(E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O => 1-aci-nitro-2-(1H-indol-3-yl)ethane + glutathione"}
{"X":50350,"RHEA_ID":48822,"compounds":"13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2"}
{"X":50351,"RHEA_ID":58853,"compounds":"(6E)-8-oxogeraniol + NAD(+) => (6E)-8-oxogeranial + H(+) + NADH"}
{"X":50352,"RHEA_ID":48824,"compounds":"GDP-beta-L-fucose + Lc4Cer = a lactoside III(4)-a-Fuc-Lc4Cer + GDP + H(+)"}
{"X":50353,"RHEA_ID":48825,"compounds":"GDP-beta-L-fucose + Lc4Cer => a lactoside III(4)-a-Fuc-Lc4Cer + GDP + H(+)"}
{"X":50354,"RHEA_ID":58855,"compounds":"(6E)-8-oxogeraniol + NAD(+) <=> (6E)-8-oxogeranial + H(+) + NADH"}
{"X":50355,"RHEA_ID":62689,"compounds":"4 norrubrofusarin + O2 => 2 H2O + 2 ustilaginoidin A"}
{"X":50356,"RHEA_ID":48828,"DIRECTION":"UN","MASTER_ID":48828,"ec":"1.14.13.219","compounds":"H(+) + NADPH + O2 + resorcinol = benzene-1,2,4-triol + H2O + NADP(+)"}
{"X":50357,"RHEA_ID":48829,"DIRECTION":"LR","MASTER_ID":48828,"metacyc":"RXN-17557","compounds":"H(+) + NADPH + O2 + resorcinol => benzene-1,2,4-triol + H2O + NADP(+)"}
{"X":50358,"RHEA_ID":48830,"compounds":"benzene-1,2,4-triol + H2O + NADP(+) => H(+) + NADPH + O2 + resorcinol"}
{"X":50359,"RHEA_ID":62705,"compounds":"glycyldehydrophenylalanine + H2O => 2,3-didehydrophenylalanine + glycine"}
{"X":50360,"RHEA_ID":48832,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate"}
{"X":50361,"RHEA_ID":48833,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate"}
{"X":50362,"RHEA_ID":48834,"compounds":"15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2"}
{"X":50363,"RHEA_ID":58865,"DIRECTION":"LR","MASTER_ID":58864,"metacyc":"RXN-11927","compounds":"4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 => 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":50364,"RHEA_ID":58866,"compounds":"4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O => 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2"}
{"X":50365,"RHEA_ID":48837,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 => (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O"}
{"X":50366,"RHEA_ID":48838,"compounds":"(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2"}
{"X":50367,"RHEA_ID":58869,"DIRECTION":"LR","MASTER_ID":58868,"metacyc":"RXN-19724","compounds":"24-methylidenelophenol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}
{"X":50368,"RHEA_ID":58870,"compounds":"4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O => 24-methylidenelophenol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2"}
{"X":50369,"RHEA_ID":48841,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 => (15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O"}
{"X":50370,"RHEA_ID":48842,"compounds":"(15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2"}
{"X":50371,"RHEA_ID":62717,"compounds":"stemphyloxin I => stemphyloxin II"}
{"X":50372,"RHEA_ID":48844,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate"}
{"X":50373,"RHEA_ID":48845,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate"}
{"X":50374,"RHEA_ID":48846,"compounds":"5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2"}
{"X":50375,"RHEA_ID":58877,"DIRECTION":"LR","MASTER_ID":58876,"metacyc":"RXN-11931","compounds":"4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":50376,"RHEA_ID":48848,"compounds":"(9Z,12Z)-octadecadienoate + O2 = 13-hydroperoxy-(9Z,11E)-octadecadienoate"}
{"X":50377,"RHEA_ID":48849,"compounds":"(9Z,12Z)-octadecadienoate + O2 => 13-hydroperoxy-(9Z,11E)-octadecadienoate"}
{"X":50378,"RHEA_ID":48850,"compounds":"13-hydroperoxy-(9Z,11E)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2"}
{"X":50379,"RHEA_ID":48851,"compounds":"(9Z,12Z)-octadecadienoate + O2 <=> 13-hydroperoxy-(9Z,11E)-octadecadienoate"}
{"X":50380,"RHEA_ID":48852,"compounds":"(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2 = 13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O"}
{"X":50381,"RHEA_ID":48853,"compounds":"(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2 => 13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O"}
{"X":50382,"RHEA_ID":48854,"compounds":"13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2"}
{"X":50383,"RHEA_ID":58885,"DIRECTION":"LR","MASTER_ID":58884,"metacyc":"RXN-20205","compounds":"AH2 + alpha-N-dichloroacetyl-p-aminophenylserinol + 2 O2 => A + chloramphenicol + 2 H2O"}
{"X":50384,"RHEA_ID":48856,"compounds":"(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + A + H2O"}
{"X":50385,"RHEA_ID":48857,"compounds":"(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 => (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + A + H2O"}
{"X":50386,"RHEA_ID":48858,"compounds":"(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + A + H2O => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2"}
{"X":50387,"RHEA_ID":58897,"compounds":"4-hydroxybutanoate + ATP + CoA => 4-hydroxybutanoyl-CoA + ADP + phosphate"}
{"X":50388,"RHEA_ID":48860,"compounds":"18-HEPE + O2 = (5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate"}
{"X":50389,"RHEA_ID":48861,"compounds":"18-HEPE + O2 => (5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate"}
{"X":50390,"RHEA_ID":48862,"compounds":"(5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate => 18-HEPE + O2"}
{"X":50391,"RHEA_ID":58901,"DIRECTION":"LR","MASTER_ID":58900,"metacyc":"RXN-20063","compounds":"1-carboxybiuret + H2O => NH4(+) + urea-1,3-dicarboxylate"}
{"X":50392,"RHEA_ID":48864,"DIRECTION":"UN","MASTER_ID":48864,"ec":"1.14.14.30","compounds":"2-methylpropan-1-amine + FADH2 + O2 = FAD + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine"}
{"X":50393,"RHEA_ID":48865,"compounds":"2-methylpropan-1-amine + FADH2 + O2 => FAD + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine"}
{"X":50394,"RHEA_ID":55551,"compounds":"N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine"}
{"X":50395,"RHEA_ID":58905,"DIRECTION":"LR","MASTER_ID":58904,"metacyc":"RXN-17321","compounds":"8 (S)-methylmalonyl-CoA + 24 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 16 NADPH => C40-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+)"}
{"X":50396,"RHEA_ID":48868,"DIRECTION":"UN","MASTER_ID":48868,"ec":"3.6.1.22","compounds":"H2O + NADH = AMP + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide"}
{"X":50397,"RHEA_ID":48869,"DIRECTION":"LR","MASTER_ID":48868,"ecocyc":"RXN0-4401","metacyc":"RXN0-4401","compounds":"H2O + NADH => AMP + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide"}
{"X":50398,"RHEA_ID":48870,"compounds":"AMP + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide => H2O + NADH"}
{"X":50399,"RHEA_ID":58909,"DIRECTION":"LR","MASTER_ID":58908,"metacyc":"RXN-17202","compounds":"7 (S)-methylmalonyl-CoA + 21 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 14 NADPH => C37-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 7 CO2 + 7 CoA + 7 H2O + 14 NADP(+)"}
{"X":50400,"RHEA_ID":48872,"DIRECTION":"UN","MASTER_ID":48872,"ec":"2.7.1.190","compounds":"a gentamycin + GTP = a gentamycin 2''-phosphate + GDP + H(+)"}
{"X":50401,"RHEA_ID":48873,"compounds":"a gentamycin + GTP => a gentamycin 2''-phosphate + GDP + H(+)"}
{"X":50402,"RHEA_ID":48874,"compounds":"a gentamycin 2''-phosphate + GDP + H(+) => a gentamycin + GTP"}
{"X":50403,"RHEA_ID":62761,"compounds":"4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":50404,"RHEA_ID":48876,"DIRECTION":"UN","MASTER_ID":48876,"ec":"3.2.1.169","compounds":"3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H2O = L-seryl-[protein] + N-acetyl-D-glucosamine"}
{"X":50405,"RHEA_ID":48877,"DIRECTION":"LR","MASTER_ID":48876,"metacyc":"RXN-11892","compounds":"3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H2O => L-seryl-[protein] + N-acetyl-D-glucosamine"}
{"X":50406,"RHEA_ID":48878,"compounds":"L-seryl-[protein] + N-acetyl-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H2O"}
{"X":50407,"RHEA_ID":58917,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + squalene => (S)-2,3-epoxysqualene + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":50408,"RHEA_ID":48880,"DIRECTION":"UN","MASTER_ID":48880,"ec":"1.2.5.3","compounds":"a quinone + CO + H2O = a quinol + CO2"}
{"X":50409,"RHEA_ID":48881,"DIRECTION":"LR","MASTER_ID":48880,"metacyc":"RXN-17357","compounds":"a quinone + CO + H2O => a quinol + CO2"}
{"X":50410,"RHEA_ID":48882,"compounds":"a quinol + CO2 => a quinone + CO + H2O"}
{"X":50411,"RHEA_ID":58921,"DIRECTION":"LR","MASTER_ID":58920,"metacyc":"RXN-18736","compounds":"(3S,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol => (+)-medicarpin + H2O"}
{"X":50412,"RHEA_ID":48884,"DIRECTION":"UN","MASTER_ID":48884,"ec":"1.3.1.75","compounds":"NADP(+) + protochlorophyllide a = 3,8-divinyl protochlorophyllide a + H(+) + NADPH"}
{"X":50413,"RHEA_ID":48885,"compounds":"NADP(+) + protochlorophyllide a => 3,8-divinyl protochlorophyllide a + H(+) + NADPH"}
{"X":50414,"RHEA_ID":62776,"compounds":"4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}
{"X":50415,"RHEA_ID":62777,"compounds":"4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}
{"X":50416,"RHEA_ID":48888,"compounds":"(13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O"}
{"X":50417,"RHEA_ID":48889,"compounds":"(13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione => (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O"}
{"X":50418,"RHEA_ID":48890,"compounds":"(13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O => (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione"}
{"X":50419,"RHEA_ID":58929,"DIRECTION":"LR","MASTER_ID":58928,"metacyc":"RXN-13699","compounds":"(3R,4R)-7,2',4'-trihydroxyisoflavanol => (6aR,11aR)-3,9-dihydroxypterocarpan + H2O"}
{"X":50420,"RHEA_ID":48892,"DIRECTION":"UN","MASTER_ID":48892,"ec":"3.2.1.169","compounds":"3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H2O = L-threonyl-[protein] + N-acetyl-D-glucosamine"}
{"X":50421,"RHEA_ID":48893,"DIRECTION":"LR","MASTER_ID":48892,"metacyc":"RXN-11891","compounds":"3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H2O => L-threonyl-[protein] + N-acetyl-D-glucosamine"}
{"X":50422,"RHEA_ID":48894,"compounds":"L-threonyl-[protein] + N-acetyl-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H2O"}
{"X":50423,"RHEA_ID":58933,"DIRECTION":"LR","MASTER_ID":58932,"metacyc":"RXN-20241","compounds":"4 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 8 H(+) + malonyl-CoA + 4 NADPH => 5 CO2 + 6 CoA + demethylluteothin + 3 H2O + 4 NADP(+)"}
{"X":50424,"RHEA_ID":52269,"DIRECTION":"LR","MASTER_ID":52268,"metacyc":"RXN-8686","compounds":"3-(aminomethyl)indole + S-adenosyl-L-methionine => (1H-indol-3-yl)-N-methylmethanamine + H(+) + S-adenosyl-L-homocysteine"}
{"X":50425,"RHEA_ID":48897,"compounds":"2 oxidized [2Fe-2S]-[ferredoxin] + protochlorophyllide a => 3,8-divinyl protochlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":50426,"RHEA_ID":48898,"DIRECTION":"RL","MASTER_ID":48896,"metacyc":"RXN-17486","compounds":"3,8-divinyl protochlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => 2 oxidized [2Fe-2S]-[ferredoxin] + protochlorophyllide a"}
{"X":50427,"RHEA_ID":58937,"compounds":"2 all-trans-geranylgeranyl diphosphate + H(+) + NADH => all-trans-lycopaoctaene + 2 diphosphate + NAD(+)"}
{"X":50428,"RHEA_ID":52273,"DIRECTION":"LR","MASTER_ID":52272,"metacyc":"RXN-8687","compounds":"(1H-indol-3-yl)-N-methylmethanamine + S-adenosyl-L-methionine => gramine + H(+) + S-adenosyl-L-homocysteine"}
{"X":50429,"RHEA_ID":48901,"compounds":"chlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin] => 3,8-divinyl chlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":50430,"RHEA_ID":48902,"DIRECTION":"RL","MASTER_ID":48900,"metacyc":"RXN-17491","compounds":"3,8-divinyl chlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => chlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":50431,"RHEA_ID":58941,"compounds":"(1R,2R,3R)-prephytoene diphosphate + H(+) + NADH => all-trans-lycopaoctaene + diphosphate + NAD(+)"}
{"X":50432,"RHEA_ID":52277,"DIRECTION":"LR","MASTER_ID":52276,"metacyc":"RXN-2","compounds":"(6S)-5,6,7,8-tetrahydrofolate + 4-hydroxy-3-methoxybenzoate => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4-dihydroxybenzoate"}
{"X":50433,"RHEA_ID":48905,"compounds":"L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H(+) + UDP"}
{"X":50434,"RHEA_ID":48906,"compounds":"3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H(+) + UDP => L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":50435,"RHEA_ID":58945,"DIRECTION":"LR","MASTER_ID":58944,"metacyc":"RXN-20242","compounds":"6 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 12 H(+) + malonyl-CoA + 6 NADPH => 7 CO2 + 8 CoA + demethyldeoxyspectinabilin + 5 H2O + 6 NADP(+)"}
{"X":50436,"RHEA_ID":52281,"DIRECTION":"LR","MASTER_ID":52280,"metacyc":"RXN-10892","compounds":"(6S)-5,6,7,8-tetrahydrofolate + 3-O-methylgallate => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4,5-trihydroxybenzoate"}
{"X":50437,"RHEA_ID":48909,"compounds":"L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP"}
{"X":50438,"RHEA_ID":48910,"compounds":"3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP => L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":50439,"RHEA_ID":58948,"compounds":"4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine = 4-O-([3-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP"}
{"X":50440,"RHEA_ID":48912,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GD1a = CMP + ganglioside GT1a + H(+)"}
{"X":50441,"RHEA_ID":48913,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GD1a => CMP + ganglioside GT1a + H(+)"}
{"X":50442,"RHEA_ID":48914,"compounds":"CMP + ganglioside GT1a + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GD1a"}
{"X":50443,"RHEA_ID":58953,"DIRECTION":"LR","MASTER_ID":58952,"metacyc":"RXN-19705","compounds":"(20S)-protopanaxatriol + UDP-alpha-D-glucose => (20S)-ginsenoside Rh1 + H(+) + UDP"}
{"X":50444,"RHEA_ID":48916,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GM1b = CMP + ganglioside GD1c + H(+)"}
{"X":50445,"RHEA_ID":48917,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GM1b => CMP + ganglioside GD1c + H(+)"}
{"X":50446,"RHEA_ID":48918,"compounds":"CMP + ganglioside GD1c + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GM1b"}
{"X":50447,"RHEA_ID":58957,"compounds":"a ribonucleotide in RNA + S-adenosyl-L-methionine => a 2'-O-methylribonucleotide in RNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":50448,"RHEA_ID":48920,"DIRECTION":"UN","MASTER_ID":48920,"ec":"1.3.7.14","compounds":"ADP + bacteriochlorophyllide g + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate = 3,8-divinyl chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":50449,"RHEA_ID":48921,"compounds":"ADP + bacteriochlorophyllide g + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate => 3,8-divinyl chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":50450,"RHEA_ID":48922,"DIRECTION":"RL","MASTER_ID":48920,"metacyc":"RXN-17477","compounds":"3,8-divinyl chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin] => ADP + bacteriochlorophyllide g + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate"}
{"X":50451,"RHEA_ID":52296,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50452,"RHEA_ID":48924,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GM4 (d18:1(4E)) = CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine"}
{"X":50453,"RHEA_ID":48925,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GM4 (d18:1(4E)) => CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine"}
{"X":50454,"RHEA_ID":55611,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base <=> a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base"}
{"X":50455,"RHEA_ID":48927,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GM4 (d18:1(4E)) <=> CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine"}
{"X":50456,"RHEA_ID":48928,"compounds":"CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-D-galactosylceramide = CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide"}
{"X":50457,"RHEA_ID":58967,"compounds":"H2O + hexanal + O2 <=> H(+) + H2O2 + hexanoate"}
{"X":50458,"RHEA_ID":52303,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50459,"RHEA_ID":58969,"compounds":"1-naphthaldehyde + H2O + O2 => 1-naphthoate + H(+) + H2O2"}
{"X":50460,"RHEA_ID":48932,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GT1b = CMP + ganglioside GQ1b + H(+)"}
{"X":50461,"RHEA_ID":58970,"compounds":"1-naphthoate + H(+) + H2O2 => 1-naphthaldehyde + H2O + O2"}
{"X":50462,"RHEA_ID":55623,"DIRECTION":"BI","MASTER_ID":55620,"metacyc":"RXN-12496","compounds":"a carotenoid psi-end group <=> a carotenoid beta-end derivative"}
{"X":50463,"RHEA_ID":58973,"compounds":"H2O + O2 + vanillin => 4-hydroxy-3-methoxybenzoate + H(+) + H2O2"}
{"X":50464,"RHEA_ID":48936,"compounds":"2-oxoglutarate + [Skp1 protein]-L-proline + O2 = [Skp1 protein]-trans-4-hydroxy-L-proline + CO2 + succinate"}
{"X":50465,"RHEA_ID":48937,"compounds":"2-oxoglutarate + [Skp1 protein]-L-proline + O2 => [Skp1 protein]-trans-4-hydroxy-L-proline + CO2 + succinate"}
{"X":50466,"RHEA_ID":48938,"compounds":"[Skp1 protein]-trans-4-hydroxy-L-proline + CO2 + succinate => 2-oxoglutarate + [Skp1 protein]-L-proline + O2"}
{"X":50467,"RHEA_ID":48939,"compounds":"2-oxoglutarate + [Skp1 protein]-L-proline + O2 <=> [Skp1 protein]-trans-4-hydroxy-L-proline + CO2 + succinate"}
{"X":50468,"RHEA_ID":48940,"DIRECTION":"UN","MASTER_ID":48940,"ec":"3.4.13.19","compounds":"an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid"}
{"X":50469,"RHEA_ID":48940,"DIRECTION":"UN","MASTER_ID":48940,"ec":"3.4.13.18","compounds":"an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid"}
{"X":50470,"RHEA_ID":48941,"DIRECTION":"LR","MASTER_ID":48940,"metacyc":"3.4.13.19-RXN","compounds":"an L-aminoacyl-L-amino acid + H2O => 2 an L-alpha-amino acid"}
{"X":50471,"RHEA_ID":48942,"compounds":"2 an L-alpha-amino acid => an L-aminoacyl-L-amino acid + H2O"}
{"X":50472,"RHEA_ID":48943,"compounds":"an L-aminoacyl-L-amino acid + H2O <=> 2 an L-alpha-amino acid"}
{"X":50473,"RHEA_ID":58982,"compounds":"3,7-dimethylocta-2,6-dienoate + H(+) + H2O2 => citral + H2O + O2"}
{"X":50474,"RHEA_ID":55643,"compounds":"C-terminal L-cysteinyl-[HypE protein] + carbamoyl adenylate <=> AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + H(+)"}
{"X":50475,"RHEA_ID":58985,"compounds":"acrolein + H2O + O2 => acrylate + H(+) + H2O2"}
{"X":50476,"RHEA_ID":48947,"compounds":"ADP + bacteriochlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate <=> 3-acetyl-3-devinylchlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":50477,"RHEA_ID":48948,"DIRECTION":"UN","MASTER_ID":48948,"ec":"1.3.7.15","compounds":"3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate = 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":50478,"RHEA_ID":48949,"compounds":"3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate => 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":50479,"RHEA_ID":58989,"compounds":"(E)-4-hydroxynon-2-enal + H2O + O2 => (E)-4-hydroxynon-2-enoate + H(+) + H2O2"}
{"X":50480,"RHEA_ID":52325,"DIRECTION":"LR","MASTER_ID":52324,"metacyc":"RXN-13568","compounds":"2 L-arginine + 4 O2 + 3 reduced [flavodoxin] => 5 H(+) + 4 H2O + 2 L-citrulline + 2 nitric oxide + 3 oxidized [flavodoxin]"}
{"X":50481,"RHEA_ID":55650,"compounds":"CO2 + H(+) + succinate + validoxylamine B => 2-oxoglutarate + O2 + validoxylamine A"}
{"X":50482,"RHEA_ID":58991,"compounds":"(E)-4-hydroxynon-2-enal + H2O + O2 <=> (E)-4-hydroxynon-2-enoate + H(+) + H2O2"}
{"X":50483,"RHEA_ID":58993,"compounds":"cinnamaldehyde + H2O + O2 => cinnamate + H(+) + H2O2"}
{"X":50484,"RHEA_ID":48955,"compounds":"14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+) <=> 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + H(+) + NADH"}
{"X":50485,"RHEA_ID":48956,"DIRECTION":"UN","MASTER_ID":48956,"ec":"1.11.1.8","compounds":"[thyroglobulin]-L-tyrosine + H(+) + H2O2 + iodide = [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O"}
{"X":50486,"RHEA_ID":48957,"DIRECTION":"LR","MASTER_ID":48956,"metacyc":"RXN-10468","compounds":"[thyroglobulin]-L-tyrosine + H(+) + H2O2 + iodide => [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O"}
{"X":50487,"RHEA_ID":48958,"compounds":"[thyroglobulin]-3-iodo-L-tyrosine + 2 H2O => [thyroglobulin]-L-tyrosine + H(+) + H2O2 + iodide"}
{"X":50488,"RHEA_ID":48959,"compounds":"[thyroglobulin]-L-tyrosine + H(+) + H2O2 + iodide <=> [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O"}
{"X":50489,"RHEA_ID":52334,"compounds":"3 H(+) + 2 H2O + 2 L-citrulline + 2 nitric oxide + oxidized [flavodoxin] => 2 N(omega)-hydroxy-L-arginine + 2 O2 + reduced [flavodoxin]"}
{"X":50490,"RHEA_ID":48961,"DIRECTION":"LR","MASTER_ID":48960,"metacyc":"RXN-10469","compounds":"[thyroglobulin]-3-iodo-L-tyrosine + H(+) + H2O2 + iodide => [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O"}
{"X":50491,"RHEA_ID":59001,"compounds":"H2O + O2 + propanal => H(+) + H2O2 + propanoate"}
{"X":50492,"RHEA_ID":48963,"compounds":"[thyroglobulin]-3-iodo-L-tyrosine + H(+) + H2O2 + iodide <=> [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O"}
{"X":50493,"RHEA_ID":59003,"compounds":"H2O + O2 + propanal <=> H(+) + H2O2 + propanoate"}
{"X":50494,"RHEA_ID":48965,"DIRECTION":"LR","MASTER_ID":48964,"metacyc":"RXN-10471","compounds":"2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 => [thyroglobulin]-dehydroalanine + [thyroglobulin]-L-thyroxine + 2 H2O"}
{"X":50495,"RHEA_ID":48966,"compounds":"[thyroglobulin]-dehydroalanine + [thyroglobulin]-L-thyroxine + 2 H2O => 2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2"}
{"X":50496,"RHEA_ID":59006,"compounds":"dodecanoate + H(+) + H2O2 => dodecanal + H2O + O2"}
{"X":50497,"RHEA_ID":48968,"DIRECTION":"UN","MASTER_ID":48968,"ec":"1.11.1.8","compounds":"[thyroglobulin]-3,5-diiodo-L-tyrosine + [thyroglobulin]-3-iodo-L-tyrosine + H2O2 = [thyroglobulin]-3,3',5-triiodo-L-thyronine + [thyroglobulin]-dehydroalanine + 2 H2O"}
{"X":50498,"RHEA_ID":48969,"DIRECTION":"LR","MASTER_ID":48968,"metacyc":"RXN-10470","compounds":"[thyroglobulin]-3,5-diiodo-L-tyrosine + [thyroglobulin]-3-iodo-L-tyrosine + H2O2 => [thyroglobulin]-3,3',5-triiodo-L-thyronine + [thyroglobulin]-dehydroalanine + 2 H2O"}
{"X":50499,"RHEA_ID":48970,"compounds":"[thyroglobulin]-3,3',5-triiodo-L-thyronine + [thyroglobulin]-dehydroalanine + 2 H2O => [thyroglobulin]-3,5-diiodo-L-tyrosine + [thyroglobulin]-3-iodo-L-tyrosine + H2O2"}
{"X":50500,"RHEA_ID":59010,"compounds":"H(+) + H2O2 + salicylate => H2O + O2 + salicylaldehyde"}
{"X":50501,"RHEA_ID":48972,"compounds":"ATP + H2O + phosphite(out) = ADP + H(+) + phosphate + phosphite(in)"}
{"X":50502,"RHEA_ID":48973,"compounds":"ATP + H2O + phosphite(out) => ADP + H(+) + phosphate + phosphite(in)"}
{"X":50503,"RHEA_ID":48974,"compounds":"ADP + H(+) + phosphate + phosphite(in) => ATP + H2O + phosphite(out)"}
{"X":50504,"RHEA_ID":59014,"compounds":"24-methylenecycloartanol + H(+) + S-adenosyl-L-homocysteine => cycloartenol + S-adenosyl-L-methionine"}
{"X":50505,"RHEA_ID":55674,"compounds":"4-O-([2-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP => 4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine"}
{"X":50506,"RHEA_ID":48977,"DIRECTION":"LR","MASTER_ID":48976,"metacyc":"RXN-11898","compounds":"5-methyl-phenazine-1-carboxylate + 2 H(+) + NADH + O2 => CO2 + H2O + NAD(+) + pyocyanin"}
{"X":50507,"RHEA_ID":48978,"compounds":"CO2 + H2O + NAD(+) + pyocyanin => 5-methyl-phenazine-1-carboxylate + 2 H(+) + NADH + O2"}
{"X":50508,"RHEA_ID":52353,"compounds":"(24S)-hydroxycholesterol 24-sulfate + 3'-phosphoadenylyl sulfate => (24S)-hydroxycholesterol 3,24-disulfate + adenosine 3',5'-bisphosphate + H(+)"}
{"X":50509,"RHEA_ID":48980,"compounds":"3,4-dichlorocatechol + O2 = (2Z,4Z)-2,3-dichloromuconate + 2 H(+)"}
{"X":50510,"RHEA_ID":48981,"compounds":"3,4-dichlorocatechol + O2 => (2Z,4Z)-2,3-dichloromuconate + 2 H(+)"}
{"X":50511,"RHEA_ID":48982,"compounds":"(2Z,4Z)-2,3-dichloromuconate + 2 H(+) => 3,4-dichlorocatechol + O2"}
{"X":50512,"RHEA_ID":59022,"compounds":"(9Z,12Z)-octadecadienoate + di-(9Z,12Z)-octadecadienoylglycerol + H(+) => 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O"}
{"X":50513,"RHEA_ID":48984,"compounds":"(2,4-dichlorophenoxy)acetate + 2-oxoglutarate + O2 = 2,4-dichlorophenol + CO2 + glyoxylate + succinate"}
{"X":50514,"RHEA_ID":48985,"DIRECTION":"LR","MASTER_ID":48984,"metacyc":"RXN-9863","compounds":"(2,4-dichlorophenoxy)acetate + 2-oxoglutarate + O2 => 2,4-dichlorophenol + CO2 + glyoxylate + succinate"}
{"X":50515,"RHEA_ID":48986,"compounds":"2,4-dichlorophenol + CO2 + glyoxylate + succinate => (2,4-dichlorophenoxy)acetate + 2-oxoglutarate + O2"}
{"X":50516,"RHEA_ID":59026,"compounds":"dihexadecanoylglycerol + H(+) + hexadecanoate => H2O + trihexadecanoylglycerol"}
{"X":50517,"RHEA_ID":55698,"compounds":"H(+) + mannosylinositol-1-phosphate + N-acyl-sphingoid base => a mannosylinositol-1-phospho-N-acyl-sphingoid base + H2O"}
{"X":50518,"RHEA_ID":48989,"compounds":"NADH + O2 + rifampicin => 2'-N-hydroxyrifampicin + H2O + NAD(+)"}
{"X":50519,"RHEA_ID":48990,"compounds":"2'-N-hydroxyrifampicin + H2O + NAD(+) => NADH + O2 + rifampicin"}
{"X":50520,"RHEA_ID":59030,"compounds":"4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O => (Z)-24-ethylidenelophenol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2"}
{"X":50521,"RHEA_ID":48992,"DIRECTION":"UN","MASTER_ID":48992,"ec":"1.14.13.212","compounds":"1,3,7-trimethylurate + H(+) + NADH + O2 = 1,3,7-trimethyl-5-hydroxyisourate + H2O + NAD(+)"}
{"X":50522,"RHEA_ID":48993,"DIRECTION":"LR","MASTER_ID":48992,"metacyc":"RXN-15454","compounds":"1,3,7-trimethylurate + H(+) + NADH + O2 => 1,3,7-trimethyl-5-hydroxyisourate + H2O + NAD(+)"}
{"X":50523,"RHEA_ID":48994,"compounds":"1,3,7-trimethyl-5-hydroxyisourate + H2O + NAD(+) => 1,3,7-trimethylurate + H(+) + NADH + O2"}
{"X":50524,"RHEA_ID":59033,"DIRECTION":"LR","MASTER_ID":59032,"metacyc":"RXN-11935","compounds":"(Z)-24-ethylidenelophenol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":50525,"RHEA_ID":60232,"compounds":"2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + O2 = CO2 + formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + succinate"}
{"X":50526,"RHEA_ID":48997,"DIRECTION":"LR","MASTER_ID":48996,"metacyc":"CATECHOL-2-3-DIOXYGENASE-RXN","compounds":"3-methylcatechol + O2 => 2-hydroxy-6-oxo-2,4-heptadienoate + H(+)"}
{"X":50527,"RHEA_ID":48998,"compounds":"2-hydroxy-6-oxo-2,4-heptadienoate + H(+) => 3-methylcatechol + O2"}
{"X":50528,"RHEA_ID":52381,"DIRECTION":"LR","MASTER_ID":52380,"metacyc":"RXN-18256","compounds":"a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate => an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+)"}
{"X":50529,"RHEA_ID":60236,"DIRECTION":"UN","MASTER_ID":60236,"ec":"1.14.11.69","compounds":"2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + 2 succinate"}
{"X":50530,"RHEA_ID":49001,"DIRECTION":"LR","MASTER_ID":49000,"metacyc":"RXN-17335","compounds":"aurachin C + H(+) + NADH + O2 => 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NAD(+)"}
{"X":50531,"RHEA_ID":49002,"compounds":"4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NAD(+) => aurachin C + H(+) + NADH + O2"}
{"X":50532,"RHEA_ID":59042,"compounds":"4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O => 4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2"}
{"X":50533,"RHEA_ID":55714,"compounds":"(9Z)-octadecenoate + (S,S)-3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+) => (S,S)-3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O"}
{"X":50534,"RHEA_ID":49005,"DIRECTION":"LR","MASTER_ID":49004,"metacyc":"RXN-17335","compounds":"aurachin C + H(+) + NADPH + O2 => 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NADP(+)"}
{"X":50535,"RHEA_ID":49006,"compounds":"4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NADP(+) => aurachin C + H(+) + NADPH + O2"}
{"X":50536,"RHEA_ID":55717,"compounds":"(S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(2'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O => (9Z)-octadecenoate + (S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+)"}
{"X":50537,"RHEA_ID":55718,"compounds":"(9Z)-octadecenoate + (S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+) => (S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(2'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O"}
{"X":50538,"RHEA_ID":49009,"DIRECTION":"LR","MASTER_ID":49008,"metacyc":"RXN-15029","compounds":"aurachin C + H(+) + NADPH + O2 => aurachin C epoxide + H2O + NADP(+)"}
{"X":50539,"RHEA_ID":49010,"compounds":"aurachin C epoxide + H2O + NADP(+) => aurachin C + H(+) + NADPH + O2"}
{"X":50540,"RHEA_ID":55721,"DIRECTION":"LR","MASTER_ID":55720,"metacyc":"RXN-18539","compounds":"17-(4-hydroxyphenyl)heptadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] => 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate"}
{"X":50541,"RHEA_ID":50187,"compounds":"N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 <=> N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-alanine"}
{"X":50542,"RHEA_ID":49013,"DIRECTION":"LR","MASTER_ID":49012,"metacyc":"RXN-15029","compounds":"aurachin C + H(+) + NADH + O2 => aurachin C epoxide + H2O + NAD(+)"}
{"X":50543,"RHEA_ID":49014,"compounds":"aurachin C epoxide + H2O + NAD(+) => aurachin C + H(+) + NADH + O2"}
{"X":50544,"RHEA_ID":59054,"compounds":"cadaverine + CO2 => D-lysine + H(+)"}
{"X":50545,"RHEA_ID":55726,"compounds":"17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+) => 17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase]"}
{"X":50546,"RHEA_ID":59056,"DIRECTION":"UN","MASTER_ID":59056,"ec":"1.8.1.21","compounds":"2 methanethiol + NAD(+) = dimethyl disulfide + H(+) + NADH"}
{"X":50547,"RHEA_ID":49018,"compounds":"2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one => aurachin C epoxide"}
{"X":50548,"RHEA_ID":49019,"compounds":"aurachin C epoxide <=> 2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one"}
{"X":50549,"RHEA_ID":59058,"DIRECTION":"RL","MASTER_ID":59056,"metacyc":"RXN-20086","compounds":"dimethyl disulfide + H(+) + NADH => 2 methanethiol + NAD(+)"}
{"X":50550,"RHEA_ID":49022,"compounds":"4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide => 2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one"}
{"X":50551,"RHEA_ID":52405,"DIRECTION":"LR","MASTER_ID":52404,"metacyc":"RXN-18588","compounds":"3-dehydro-4-O-phospho-L-erythronate + H(+) => CO2 + dihydroxyacetone phosphate"}
{"X":50552,"RHEA_ID":55734,"compounds":"19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+) => 19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase]"}
{"X":50553,"RHEA_ID":59063,"compounds":"(20S)-ginsenoside Rg3 + H2O <=> (20S)-ginsenoside Rh2 + D-glucose"}
{"X":50554,"RHEA_ID":49026,"compounds":"2-iminio-3-(indol-3-yl)propanoate + H2O2 => L-tryptophan + O2"}
{"X":50555,"RHEA_ID":49027,"compounds":"L-tryptophan + O2 <=> 2-iminio-3-(indol-3-yl)propanoate + H2O2"}
{"X":50556,"RHEA_ID":55738,"compounds":"[(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP => alpha-D-galacturonosyl-[(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n) + UDP-beta-L-rhamnose"}
{"X":50557,"RHEA_ID":55739,"compounds":"alpha-D-galacturonosyl-[(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n) + UDP-beta-L-rhamnose <=> [(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP"}
{"X":50558,"RHEA_ID":49030,"compounds":"(-)-5'-demethylyatein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-bursehernin + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":50559,"RHEA_ID":59070,"compounds":"deoxyspectinabilin + S-adenosyl-L-homocysteine => demethyldeoxyspectinabilin + S-adenosyl-L-methionine"}
{"X":50560,"RHEA_ID":52414,"compounds":"3-dehydro-4-O-phospho-D-erythronate + H(+) + NADH => 4-phospho-D-erythronate + NAD(+)"}
{"X":50561,"RHEA_ID":59071,"compounds":"demethyldeoxyspectinabilin + S-adenosyl-L-methionine <=> deoxyspectinabilin + S-adenosyl-L-homocysteine"}
{"X":50562,"RHEA_ID":52416,"DIRECTION":"UN","MASTER_ID":52416,"ec":"4.1.1.104","compounds":"3-dehydro-4-O-phospho-D-erythronate + H(+) = CO2 + dihydroxyacetone phosphate"}
{"X":50563,"RHEA_ID":59074,"compounds":"5'-deoxyadenosine + A + cytidine 5'-{[hydroxy(2-hydroxypropyl)phosphonoyl]phosphate} + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine => AH2 + cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + 2 S-adenosyl-L-methionine"}
{"X":50564,"RHEA_ID":52418,"compounds":"CO2 + dihydroxyacetone phosphate => 3-dehydro-4-O-phospho-D-erythronate + H(+)"}
{"X":50565,"RHEA_ID":59075,"compounds":"AH2 + cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + 2 S-adenosyl-L-methionine <=> 5'-deoxyadenosine + A + cytidine 5'-{[hydroxy(2-hydroxypropyl)phosphonoyl]phosphate} + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine"}
{"X":50566,"RHEA_ID":52420,"DIRECTION":"UN","MASTER_ID":52420,"ec":"2.8.5.1","compounds":"O-phospho-L-serine + thiosulfate = phosphate + S-sulfo-L-cysteine"}
{"X":50567,"RHEA_ID":59078,"compounds":"2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + 2 GDP + 2 H(+) => bis(myo-inositol) 1,3'-phosphate + 2 GDP-alpha-D-mannose"}
{"X":50568,"RHEA_ID":55750,"DIRECTION":"RL","MASTER_ID":55748,"metacyc":"RXN-18521","compounds":"coenzyme M-coenzyme B heterodisulfide + 2 H2 + 2 oxidized [2Fe-2S]-[ferredoxin] => coenzyme B + coenzyme M + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":50569,"RHEA_ID":59079,"compounds":"bis(myo-inositol) 1,3'-phosphate + 2 GDP-alpha-D-mannose <=> 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + 2 GDP + 2 H(+)"}
{"X":50570,"RHEA_ID":52424,"DIRECTION":"UN","MASTER_ID":52424,"ec":"2.4.1.41","compounds":"L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP"}
{"X":50571,"RHEA_ID":59082,"compounds":"2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+) => bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose"}
{"X":50572,"RHEA_ID":52426,"compounds":"3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP => L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine"}
{"X":50573,"RHEA_ID":49045,"DIRECTION":"LR","MASTER_ID":49044,"metacyc":"RXN-17359","compounds":"H(+) + NADH + O2 + protoasukamycin => 4-hydroxyprotoasukamycin + H2O + NAD(+)"}
{"X":50574,"RHEA_ID":52428,"compounds":"12-oxo-leukotriene B4 + H(+) + NADH = 12-oxo-(5S)-hydroxy-(6Z,8E,14Z)-eicosatrienoate + NAD(+)"}
{"X":50575,"RHEA_ID":59086,"compounds":"2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+) => 2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose"}
{"X":50576,"RHEA_ID":52430,"compounds":"12-oxo-(5S)-hydroxy-(6Z,8E,14Z)-eicosatrienoate + NAD(+) => 12-oxo-leukotriene B4 + H(+) + NADH"}
{"X":50577,"RHEA_ID":59087,"compounds":"2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose <=> 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+)"}
{"X":50578,"RHEA_ID":52432,"DIRECTION":"UN","MASTER_ID":52432,"ec":"4.3.1.15","compounds":"(R)-2,3-diaminopropanoate + H(+) + H2O = 2 NH4(+) + pyruvate"}
{"X":50579,"RHEA_ID":49051,"compounds":"25-hydroxyvitamin D2 + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 1alpha,25-dihydroxyvitamin D2 + H2O + 2 oxidized [adrenodoxin]"}
{"X":50580,"RHEA_ID":52434,"compounds":"2 NH4(+) + pyruvate => (R)-2,3-diaminopropanoate + H(+) + H2O"}
{"X":50581,"RHEA_ID":55763,"compounds":"a fatty acyl-[ACP] + a lyso-ornithine lipid <=> an N(2)-[(3R)-3-(acyloxy)acyl]-L-ornithine lipid + holo-[ACP]"}
{"X":50582,"RHEA_ID":49054,"compounds":"asperlicin E + H2O + NAD(+) => asperlicin C + H(+) + NADH + O2"}
{"X":50583,"RHEA_ID":59094,"compounds":"[(1->3)-alpha-D-glucosyl](n+1) + D-fructose => [(1->3)-alpha-D-glucosyl](n) + sucrose"}
{"X":50584,"RHEA_ID":55766,"compounds":"2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol => 1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O"}
{"X":50585,"RHEA_ID":53537,"compounds":"(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O => (13R,14S)-dihydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate"}
{"X":50586,"RHEA_ID":49058,"compounds":"asperlicin E + H2O + NADP(+) => asperlicin C + H(+) + NADPH + O2"}
{"X":50587,"RHEA_ID":59098,"compounds":"diglucosyl-enterobactin + H(+) + UDP => monoglucosyl-enterobactin + UDP-alpha-D-glucose"}
{"X":50588,"RHEA_ID":52442,"compounds":"a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+) => 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1->2)-D-myo-inositol] + GDP-alpha-D-mannose"}
{"X":50589,"RHEA_ID":49061,"DIRECTION":"LR","MASTER_ID":49060,"metacyc":"RXN-17333","compounds":"a long-chain alkane + FMNH2 + O2 => a long chain fatty alcohol + FMN + H(+) + H2O"}
{"X":50590,"RHEA_ID":49062,"compounds":"a long chain fatty alcohol + FMN + H(+) + H2O => a long-chain alkane + FMNH2 + O2"}
{"X":50591,"RHEA_ID":49063,"compounds":"a long-chain alkane + FMNH2 + O2 <=> a long chain fatty alcohol + FMN + H(+) + H2O"}
{"X":50592,"RHEA_ID":49064,"DIRECTION":"UN","MASTER_ID":49064,"ec":"1.14.15.18","compounds":"2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol = calcitetrol + H2O + 2 oxidized [adrenodoxin]"}
{"X":50593,"RHEA_ID":55775,"compounds":"a jasmonate + an L-alpha-amino acid + ATP <=> a jasmonyl-L-amino acid + AMP + diphosphate + H(+)"}
{"X":50594,"RHEA_ID":52448,"compounds":"16alpha-hydroxyestrone + UDP-alpha-D-glucuronate = 16alpha-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":50595,"RHEA_ID":59106,"compounds":"beta-D-glucosyl-(1->3)-O-chenodeoxycholate + dolichyl phosphate + H(+) => chenodeoxycholate + dolichyl beta-D-glucosyl phosphate"}
{"X":50596,"RHEA_ID":49068,"compounds":"25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (1S)-1,25-dihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin]"}
{"X":50597,"RHEA_ID":49069,"compounds":"25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (1S)-1,25-dihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin]"}
{"X":50598,"RHEA_ID":52452,"compounds":"16alpha-hydroxyestrone + UDP-alpha-D-glucuronate = 16alpha-hydroxyestrone 16-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":50599,"RHEA_ID":50245,"DIRECTION":"LR","MASTER_ID":50244,"metacyc":"RXN66-341","compounds":"17alpha-hydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase] => 3beta-hydroxyandrost-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50600,"RHEA_ID":59110,"compounds":"beta-D-glucosyl-(1->3)-O-chenodeoxycholate + octan-1-ol => chenodeoxycholate + octyl beta-D-glucose"}
{"X":50601,"RHEA_ID":49073,"compounds":"dibenzothiophene + 2 FMNH2 + 2 O2 => dibenzothiophene 5,5-dioxide + 2 FMN + 2 H(+) + 2 H2O"}
{"X":50602,"RHEA_ID":49074,"compounds":"dibenzothiophene 5,5-dioxide + 2 FMN + 2 H(+) + 2 H2O => dibenzothiophene + 2 FMNH2 + 2 O2"}
{"X":50603,"RHEA_ID":59114,"compounds":"ADP + H(+) + O-phospho-L-serine => ATP + L-serine"}
{"X":50604,"RHEA_ID":55786,"compounds":"all-trans-4-oxoretinoate 1-O-(beta-D-glucuronate) + UDP => all-trans-4-oxoretinoate + UDP-alpha-D-glucuronate"}
{"X":50605,"RHEA_ID":49077,"DIRECTION":"LR","MASTER_ID":49076,"metacyc":"RXN-621","compounds":"dibenzothiophene + FMNH2 + O2 => dibenzothiophene 5-oxide + FMN + H(+) + H2O"}
{"X":50606,"RHEA_ID":49078,"compounds":"dibenzothiophene 5-oxide + FMN + H(+) + H2O => dibenzothiophene + FMNH2 + O2"}
{"X":50607,"RHEA_ID":59118,"compounds":"[protein]-disulfide + H2O2 => [protein]-dithiol + O2"}
{"X":50608,"RHEA_ID":50254,"compounds":"a 3-oxoacyl-CoA + CO2 + CoA => an acyl-CoA + H(+) + malonyl-CoA"}
{"X":50609,"RHEA_ID":49081,"DIRECTION":"LR","MASTER_ID":49080,"metacyc":"RXN-622","compounds":"dibenzothiophene 5-oxide + FMNH2 + O2 => dibenzothiophene 5,5-dioxide + FMN + H(+) + H2O"}
{"X":50610,"RHEA_ID":49082,"compounds":"dibenzothiophene 5,5-dioxide + FMN + H(+) + H2O => dibenzothiophene 5-oxide + FMNH2 + O2"}
{"X":50611,"RHEA_ID":50257,"compounds":"cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 25-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50612,"RHEA_ID":50258,"compounds":"25-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":50613,"RHEA_ID":49085,"DIRECTION":"LR","MASTER_ID":49084,"metacyc":"RXN-16360","compounds":"(-)-matairesinol + O2 + reduced [NADPH--hemoprotein reductase] => (-)-pluviatolide + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50614,"RHEA_ID":49086,"compounds":"(-)-pluviatolide + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (-)-matairesinol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":50615,"RHEA_ID":59126,"compounds":"2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + AMP + diphosphate => (S)-2,3-diaminopropanoate + ATP + citrate"}
{"X":50616,"RHEA_ID":59127,"compounds":"(S)-2,3-diaminopropanoate + ATP + citrate <=> 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + AMP + diphosphate"}
{"X":50617,"RHEA_ID":49089,"compounds":"FAD + H(+) + H2O + squalene => FADH2 + hydroxysqualene"}
{"X":50618,"RHEA_ID":49090,"DIRECTION":"RL","MASTER_ID":49088,"metacyc":"RXN-17128","compounds":"FADH2 + hydroxysqualene => FAD + H(+) + H2O + squalene"}
{"X":50619,"RHEA_ID":59130,"compounds":"2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + AMP + diphosphate => (S)-2,3-diaminopropanoate + 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + ATP"}
{"X":50620,"RHEA_ID":50266,"compounds":"26-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":50621,"RHEA_ID":49093,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphate + H2O => H(+) + hexadecanoate + sn-glycerol 3-phosphate"}
{"X":50622,"RHEA_ID":49094,"compounds":"H(+) + hexadecanoate + sn-glycerol 3-phosphate => 1-hexadecanoyl-sn-glycero-3-phosphate + H2O"}
{"X":50623,"RHEA_ID":49095,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphate + H2O <=> H(+) + hexadecanoate + sn-glycerol 3-phosphate"}
{"X":50624,"RHEA_ID":59135,"compounds":"2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + 2-oxoglutarate + ATP <=> AMP + diphosphate + H(+) + staphyloferrin B"}
{"X":50625,"RHEA_ID":49097,"DIRECTION":"LR","MASTER_ID":49096,"metacyc":"RXN-13852","compounds":"H2O + Mg-protoporphyrin IX 13-monomethyl ester + 3 S-adenosyl-L-methionine => 3,8-divinyl protochlorophyllide a + 3 5'-deoxyadenosine + 4 H(+) + 3 L-methionine"}
{"X":50626,"RHEA_ID":49098,"compounds":"3,8-divinyl protochlorophyllide a + 3 5'-deoxyadenosine + 4 H(+) + 3 L-methionine => H2O + Mg-protoporphyrin IX 13-monomethyl ester + 3 S-adenosyl-L-methionine"}
{"X":50627,"RHEA_ID":52481,"compounds":"16-methoxytabersonine + O2 + reduced [NADPH--hemoprotein reductase] => (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50628,"RHEA_ID":52482,"compounds":"(3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 16-methoxytabersonine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":50629,"RHEA_ID":49101,"DIRECTION":"LR","MASTER_ID":49100,"metacyc":"RXN-8797","compounds":"H2O + Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-methionine => 5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester"}
{"X":50630,"RHEA_ID":49102,"compounds":"5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester => H2O + Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-methionine"}
{"X":50631,"RHEA_ID":55813,"DIRECTION":"LR","MASTER_ID":55812,"metacyc":"RXN-18422","compounds":"a bacteriochlorophyllide d + H2O + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + a bacteriochlorophyllide f + 2 H(+) + 2 L-methionine"}
{"X":50632,"RHEA_ID":50278,"compounds":"(12S)-hydroperoxy-(14R,15S)-epoxy-(5Z,8Z,10E)-eicosatrienoate => (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2"}
{"X":50633,"RHEA_ID":55815,"compounds":"a bacteriochlorophyllide d + H2O + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + a bacteriochlorophyllide f + 2 H(+) + 2 L-methionine"}
{"X":50634,"RHEA_ID":49106,"compounds":"5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester => Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine"}
{"X":50635,"RHEA_ID":59146,"compounds":"5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + 7,8-dihydrofolate => 10-formyldihydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide"}
{"X":50636,"RHEA_ID":59147,"compounds":"10-formyldihydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide <=> 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + 7,8-dihydrofolate"}
{"X":50637,"RHEA_ID":55819,"compounds":"a bacteriochlorophyllide d + H2O + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide d + H(+) + L-methionine"}
{"X":50638,"RHEA_ID":49110,"compounds":"3,8-divinyl protochlorophyllide a + 5'-deoxyadenosine + 2 H(+) + L-methionine => Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine"}
{"X":50639,"RHEA_ID":59166,"compounds":"AMP + diphosphate + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] => ATP + hexadecanoate + holo-[(hydroxy)phthioceranic acid synthase]"}
{"X":50640,"RHEA_ID":49112,"DIRECTION":"UN","MASTER_ID":49112,"ec":"2.1.1.327","compounds":"phenazine-1-carboxylate + S-adenosyl-L-methionine = 5-methyl-phenazine-1-carboxylate + S-adenosyl-L-homocysteine"}
{"X":50641,"RHEA_ID":49113,"DIRECTION":"LR","MASTER_ID":49112,"metacyc":"RXN-11897","compounds":"phenazine-1-carboxylate + S-adenosyl-L-methionine => 5-methyl-phenazine-1-carboxylate + S-adenosyl-L-homocysteine"}
{"X":50642,"RHEA_ID":49114,"compounds":"5-methyl-phenazine-1-carboxylate + S-adenosyl-L-homocysteine => phenazine-1-carboxylate + S-adenosyl-L-methionine"}
{"X":50643,"RHEA_ID":59170,"compounds":"AMP + diphosphate + octadecanoyl-[(hydroxy)phthioceranic acid synthase] => ATP + holo-[(hydroxy)phthioceranic acid synthase] + octadecanoate"}
{"X":50644,"RHEA_ID":55826,"compounds":"a bacteriochlorophyllide f + H2O => a 7(1),7(1)-dihydroxybacteriochlorophyllide d"}
{"X":50645,"RHEA_ID":55827,"compounds":"a 7(1),7(1)-dihydroxybacteriochlorophyllide d <=> a bacteriochlorophyllide f + H2O"}
{"X":50646,"RHEA_ID":49118,"compounds":"deoxyviolaceinate + H2O + NADP(+) => H(+) + NADPH + O2 + protodeoxyviolaceinate"}
{"X":50647,"RHEA_ID":59174,"compounds":"AMP + H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] => hexadecanoyl-AMP + holo-[(hydroxy)phthioceranic acid synthase]"}
{"X":50648,"RHEA_ID":50294,"compounds":"all-trans-3,4-didehydroretinol + 2 H2O + 2 oxidized [adrenodoxin] => all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}
{"X":50649,"RHEA_ID":49121,"DIRECTION":"LR","MASTER_ID":49120,"metacyc":"RXN-13342","compounds":"H(+) + NADPH + O2 + protoviolaceinate => H2O + NADP(+) + violaceinate"}
{"X":50650,"RHEA_ID":49122,"compounds":"H2O + NADP(+) + violaceinate => H(+) + NADPH + O2 + protoviolaceinate"}
{"X":50651,"RHEA_ID":52505,"compounds":"(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] => 9(R)-hydroxy-(10E,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50652,"RHEA_ID":52506,"compounds":"9(R)-hydroxy-(10E,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":50653,"RHEA_ID":49125,"DIRECTION":"LR","MASTER_ID":49124,"metacyc":"RXN-13341","compounds":"H(+) + NADPH + O2 + protodeoxyviolaceinate => H2O + NADP(+) + protoviolaceinate"}
{"X":50654,"RHEA_ID":49126,"compounds":"H2O + NADP(+) + protoviolaceinate => H(+) + NADPH + O2 + protodeoxyviolaceinate"}
{"X":50655,"RHEA_ID":59182,"compounds":"2 AMP + H(+) => 5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O"}
{"X":50656,"RHEA_ID":52510,"compounds":"13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":50657,"RHEA_ID":49129,"compounds":"AH2 + N-acetyl-demethyl-L-phosphinothricin + 2 S-adenosyl-L-methionine => 5'-deoxyadenosine + A + 2 H(+) + L-methionine + N-acetyl-L-phosphinothricin + S-adenosyl-L-homocysteine"}
{"X":50658,"RHEA_ID":52512,"DIRECTION":"UN","MASTER_ID":52512,"ec":"1.5.5.3","compounds":"a quinone + trans-4-hydroxy-L-proline = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)"}
{"X":50659,"RHEA_ID":52513,"DIRECTION":"LR","MASTER_ID":52512,"metacyc":"RXN66-545","compounds":"a quinone + trans-4-hydroxy-L-proline => (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)"}
{"X":50660,"RHEA_ID":52514,"compounds":"(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+) => a quinone + trans-4-hydroxy-L-proline"}
{"X":50661,"RHEA_ID":49133,"compounds":"an adenosine in tRNA + S-adenosyl-L-methionine => an N(1)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":50662,"RHEA_ID":49134,"compounds":"an N(1)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine => an adenosine in tRNA + S-adenosyl-L-methionine"}
{"X":50663,"RHEA_ID":49135,"compounds":"an adenosine in tRNA + S-adenosyl-L-methionine <=> an N(1)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":50664,"RHEA_ID":52518,"compounds":"(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + H(+) + ubiquinol-10 => trans-4-hydroxy-L-proline + ubiquinone-10"}
{"X":50665,"RHEA_ID":49137,"compounds":"H(+) + L-methionyl-[protein] + NADPH + O2 => H2O + L-methionyl-S-oxide-[protein] + NADP(+)"}
{"X":50666,"RHEA_ID":49138,"compounds":"H2O + L-methionyl-S-oxide-[protein] + NADP(+) => H(+) + L-methionyl-[protein] + NADPH + O2"}
{"X":50667,"RHEA_ID":52521,"compounds":"O2 + prostaglandin E1 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy prostaglandin E1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50668,"RHEA_ID":55850,"compounds":"[(2->6)-alpha-D-glucosyl-(1->4)-N,7-O-diacetyl-alpha-D-neuraminosyl](n) + n CoA => [(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA"}
{"X":50669,"RHEA_ID":49141,"DIRECTION":"LR","MASTER_ID":49140,"metacyc":"RXN-12406","compounds":"dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":50670,"RHEA_ID":49142,"compounds":"dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":50671,"RHEA_ID":59214,"compounds":"AMP + H(+) + octadecanoyl-[(hydroxy)phthioceranic acid synthase] => holo-[(hydroxy)phthioceranic acid synthase] + octadecanoyl-AMP"}
{"X":50672,"RHEA_ID":52526,"compounds":"20-hydroxy prostaglandin A1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + prostaglandin A1 + reduced [NADPH--hemoprotein reductase]"}
{"X":50673,"RHEA_ID":49145,"compounds":"2-oxoglutarate + dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose => dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + L-glutamate"}
{"X":50674,"RHEA_ID":49146,"compounds":"dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + L-glutamate => 2-oxoglutarate + dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose"}
{"X":50675,"RHEA_ID":52529,"compounds":"2-oxoglutarate + L-asparagine => 2-oxosuccinamate + L-glutamate"}
{"X":50676,"RHEA_ID":59219,"compounds":"(indol-3-yl)acetate + H(+) <=> CO2 + skatole"}
{"X":50677,"RHEA_ID":49149,"DIRECTION":"LR","MASTER_ID":49148,"metacyc":"RXN-17384","compounds":"dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + 2 S-adenosyl-L-methionine => dTDP-alpha-D-forosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine"}
{"X":50678,"RHEA_ID":49150,"compounds":"dTDP-alpha-D-forosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine => dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + 2 S-adenosyl-L-methionine"}
{"X":50679,"RHEA_ID":59222,"compounds":"(2Z)-2-hydroxypenta-2,4-dienoate + acetate + H(+) => (2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate + H2O"}
{"X":50680,"RHEA_ID":52534,"compounds":"AMP + GDP + H(+) => adenosine + GTP"}
{"X":50681,"RHEA_ID":49153,"DIRECTION":"LR","MASTER_ID":49152,"metacyc":"RXN-12409","compounds":"dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine => dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + H(+) + S-adenosyl-L-homocysteine"}
{"X":50682,"RHEA_ID":49154,"compounds":"dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + H(+) + S-adenosyl-L-homocysteine => dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine"}
{"X":50683,"RHEA_ID":59226,"compounds":"diphosphate + hydropyrene => all-trans-geranylgeranyl diphosphate"}
{"X":50684,"RHEA_ID":52538,"compounds":"AMP + dGDP + H(+) => adenosine + dGTP"}
{"X":50685,"RHEA_ID":49157,"DIRECTION":"LR","MASTER_ID":49156,"metacyc":"RXN-12408","compounds":"dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine => dTDP-alpha-D-forosamine + H(+) + S-adenosyl-L-homocysteine"}
{"X":50686,"RHEA_ID":49158,"compounds":"dTDP-alpha-D-forosamine + H(+) + S-adenosyl-L-homocysteine => dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine"}
{"X":50687,"RHEA_ID":59230,"compounds":"6-sulfo-beta-D-quinovose => 6-sulfo-alpha-D-quinovose"}
{"X":50688,"RHEA_ID":52542,"compounds":"alpha-D-ribose 1-phosphate + cytosine => cytidine + phosphate"}
{"X":50689,"RHEA_ID":49161,"compounds":"1,4-cineole + O2 + reduced [NADPH--hemoprotein reductase] => 2-exo-hydroxy-1,4-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50690,"RHEA_ID":49162,"compounds":"2-exo-hydroxy-1,4-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 1,4-cineole + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":50691,"RHEA_ID":49163,"compounds":"1,4-cineole + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-exo-hydroxy-1,4-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50692,"RHEA_ID":59235,"compounds":"all-trans-geranylgeranyl diphosphate + H2O <=> diphosphate + hydropyrenol"}
{"X":50693,"RHEA_ID":49165,"DIRECTION":"LR","MASTER_ID":49164,"metacyc":"RXN-17454","compounds":"a bacteriochlorophyllide c + H2O + S-adenosyl-L-methionine => 5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide c + H(+) + L-methionine"}
{"X":50694,"RHEA_ID":49166,"compounds":"5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide c + H(+) + L-methionine => a bacteriochlorophyllide c + H2O + S-adenosyl-L-methionine"}
{"X":50695,"RHEA_ID":59238,"compounds":"diphosphate + isoelisabethatriene => all-trans-geranylgeranyl diphosphate"}
{"X":50696,"RHEA_ID":49168,"DIRECTION":"UN","MASTER_ID":49168,"ec":"2.1.1.331","compounds":"8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine = 8,12-diethyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine"}
{"X":50697,"RHEA_ID":59239,"compounds":"all-trans-geranylgeranyl diphosphate <=> diphosphate + isoelisabethatriene"}
{"X":50698,"RHEA_ID":49170,"compounds":"8,12-diethyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine => 8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine"}
{"X":50699,"RHEA_ID":52553,"DIRECTION":"LR","MASTER_ID":52552,"metacyc":"RXN-18595","compounds":"3-dehydro-L-erythronate + ATP => 3-dehydro-4-O-phospho-L-erythronate + ADP + H(+)"}
{"X":50700,"RHEA_ID":55886,"compounds":"[aequorin]--dioxetanone => [aequorin] + 3 Ca(2+)"}
{"X":50701,"RHEA_ID":49173,"DIRECTION":"LR","MASTER_ID":49172,"metacyc":"RXN-17431","compounds":"8,12-diethyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine => 12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine"}
{"X":50702,"RHEA_ID":49174,"compounds":"12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine => 8,12-diethyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine"}
{"X":50703,"RHEA_ID":52557,"DIRECTION":"LR","MASTER_ID":52556,"metacyc":"RXN-18594","compounds":"3-dehydro-D-erythronate + ATP => 3-dehydro-4-O-phospho-D-erythronate + ADP + H(+)"}
{"X":50704,"RHEA_ID":55890,"compounds":"[excited state blue fluorescent protein] + CO2 => [aequorin]--dioxetanone"}
{"X":50705,"RHEA_ID":49177,"DIRECTION":"LR","MASTER_ID":49176,"metacyc":"RXN-17432","compounds":"12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine => 12-ethyl-8-isobutyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine"}
{"X":50706,"RHEA_ID":49178,"compounds":"12-ethyl-8-isobutyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine => 12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine"}
{"X":50707,"RHEA_ID":59250,"compounds":"(R)-3-(4-hydroxyphenyl)lactoyl-CoA + trans-4-coumarate => (2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + (E)-4-coumaroyl-CoA"}
{"X":50708,"RHEA_ID":55894,"compounds":"a 3-(all-trans-polyprenyl)benzene-1,2-diol + H2O + NADP(+) => a 2-all-trans-polyprenylphenol + H(+) + NADPH + O2"}
{"X":50709,"RHEA_ID":59251,"DIRECTION":"BI","MASTER_ID":59248,"metacyc":"RXN-19897","compounds":"(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + (E)-4-coumaroyl-CoA <=> (R)-3-(4-hydroxyphenyl)lactoyl-CoA + trans-4-coumarate"}
{"X":50710,"RHEA_ID":59253,"compounds":"(E)-3-(indol-3-yl)acryloyl-CoA + (R)-3-(indol-3-yl)lactate => (E)-3-(indol-3-yl)acrylate + (R)-3-(indol-3-yl)lactoyl-CoA"}
{"X":50711,"RHEA_ID":59254,"compounds":"(E)-3-(indol-3-yl)acrylate + (R)-3-(indol-3-yl)lactoyl-CoA => (E)-3-(indol-3-yl)acryloyl-CoA + (R)-3-(indol-3-yl)lactate"}
{"X":50712,"RHEA_ID":50358,"compounds":"4-dedimethylamino-4-oxo-anhydrotetracycline + H2O + NADP(+) => 4-hydroxy-6-methylpretetramide + NADPH + O2"}
{"X":50713,"RHEA_ID":60437,"DIRECTION":"LR","MASTER_ID":60436,"metacyc":"RXN-19385","compounds":"3-methylbutyl acetate + H2O => 3-methylbutanol + acetate + H(+)"}
{"X":50714,"RHEA_ID":49186,"compounds":"8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + CO2 + methanol => chlorophyllide a + H(+) + H2O"}
{"X":50715,"RHEA_ID":52569,"compounds":"epitestosterone + UDP-alpha-D-glucuronate => epitestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":50716,"RHEA_ID":52570,"compounds":"epitestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP => epitestosterone + UDP-alpha-D-glucuronate"}
{"X":50717,"RHEA_ID":49189,"compounds":"a bacteriochlorophyllide d => a 3-vinylbacteriochlorophyllide d + H2O"}
{"X":50718,"RHEA_ID":49190,"DIRECTION":"RL","MASTER_ID":49188,"metacyc":"RXN-17450","compounds":"a 3-vinylbacteriochlorophyllide d + H2O => a bacteriochlorophyllide d"}
{"X":50719,"RHEA_ID":52573,"compounds":"butanoyl-CoA + NAD(+) => (2E)-butenoyl-CoA + H(+) + NADH"}
{"X":50720,"RHEA_ID":55906,"compounds":"6,7-dichloro-L-tryptophan + FAD + 2 H2O => 7-chloro-L-tryptophan + chloride + FADH2 + O2"}
{"X":50721,"RHEA_ID":59263,"compounds":"Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+) + H2O <=> Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine"}
{"X":50722,"RHEA_ID":49194,"compounds":"1alpha,23S,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin] => calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}
{"X":50723,"RHEA_ID":49195,"compounds":"calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 1alpha,23S,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]"}
{"X":50724,"RHEA_ID":52578,"compounds":"(2E)-hexenoyl-CoA + H(+) + NADH => hexanoyl-CoA + NAD(+)"}
{"X":50725,"RHEA_ID":49197,"compounds":"2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol => 25-hydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin]"}
{"X":50726,"RHEA_ID":49198,"compounds":"25-hydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin] => 2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol"}
{"X":50727,"RHEA_ID":49199,"compounds":"2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol <=> 25-hydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin]"}
{"X":50728,"RHEA_ID":52582,"compounds":"ADP + H(+) + Pb(2+)(out) + phosphate => ATP + H2O + Pb(2+)(in)"}
{"X":50729,"RHEA_ID":49201,"DIRECTION":"LR","MASTER_ID":49200,"metacyc":"RXN-9991","compounds":"D-mannose 6-phosphate + H2O + phosphoenolpyruvate => 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + phosphate"}
{"X":50730,"RHEA_ID":49202,"compounds":"3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + phosphate => D-mannose 6-phosphate + H2O + phosphoenolpyruvate"}
{"X":50731,"RHEA_ID":59274,"compounds":"D-cysteine => L-cysteine"}
{"X":50732,"RHEA_ID":50378,"compounds":"a ceramide(out) + ADP + H(+) + phosphate => a ceramide(in) + ATP + H2O"}
{"X":50733,"RHEA_ID":49205,"compounds":"20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 20S,24R-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]"}
{"X":50734,"RHEA_ID":49206,"compounds":"20S,24R-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin] => 20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}
{"X":50735,"RHEA_ID":49207,"compounds":"20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 20S,24R-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]"}
{"X":50736,"RHEA_ID":52590,"compounds":"7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH => choloyl-CoA + NAD(+)"}
{"X":50737,"RHEA_ID":57023,"compounds":"apulose + ATP <=> ADP + apulose 4-phosphate + H(+)"}
{"X":50738,"RHEA_ID":49210,"compounds":"20S,24S-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin] => 20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}
{"X":50739,"RHEA_ID":49211,"compounds":"20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 20S,24S-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]"}
{"X":50740,"RHEA_ID":52594,"DIRECTION":"RL","MASTER_ID":52592,"metacyc":"3OHSTEROXRED-RXN","compounds":"12alpha-hydroxy-3-oxocholan-24-oyl-CoA + H(+) + NADH => deoxycholoyl-CoA + NAD(+)"}
{"X":50741,"RHEA_ID":49213,"compounds":"20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 20S,25-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]"}
{"X":50742,"RHEA_ID":49214,"compounds":"20S,25-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin] => 20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}
{"X":50743,"RHEA_ID":49215,"compounds":"20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 20S,25-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]"}
{"X":50744,"RHEA_ID":52598,"DIRECTION":"RL","MASTER_ID":52596,"metacyc":"RXN-17404","compounds":"3-oxocholan-24-oyl-CoA + H(+) + NADH => lithocholoyl-CoA + NAD(+)"}
{"X":50745,"RHEA_ID":49217,"DIRECTION":"LR","MASTER_ID":49216,"metacyc":"RXN-9992","compounds":"3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + H2O => 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + phosphate"}
{"X":50746,"RHEA_ID":49218,"compounds":"3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + phosphate => 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + H2O"}
{"X":50747,"RHEA_ID":59290,"compounds":"D-glucose + sphing-4-enine => beta-D-glucosyl-(1<->1)-sphing-4-enine + H2O"}
{"X":50748,"RHEA_ID":55946,"compounds":"2 [Fe(II)cytochrome c] + chloroacetaldehyde + 2 H(+) => 2-chloroethanol + 2 [Fe(III)cytochrome c]"}
{"X":50749,"RHEA_ID":49221,"DIRECTION":"LR","MASTER_ID":49220,"metacyc":"RXN-9993","compounds":"3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + CTP => CMP-beta-3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + diphosphate"}
{"X":50750,"RHEA_ID":49222,"compounds":"CMP-beta-3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + diphosphate => 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + CTP"}
{"X":50751,"RHEA_ID":52605,"compounds":"3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-seryl-[protein] + ATP => 3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-6-O-phospho-alpha-D-mannosyl)-L-seryl-[protein] + ADP + H(+)"}
{"X":50752,"RHEA_ID":55950,"compounds":"AH2 + NH4(+) + pyruvate => A + D-alanine + H2O"}
{"X":50753,"RHEA_ID":49225,"compounds":"dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + reduced [flavodoxin] => dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H(+) + H2O + oxidized [flavodoxin]"}
{"X":50754,"RHEA_ID":49226,"compounds":"dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H(+) + H2O + oxidized [flavodoxin] => dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + reduced [flavodoxin]"}
{"X":50755,"RHEA_ID":49227,"compounds":"dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + reduced [flavodoxin] <=> dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H(+) + H2O + oxidized [flavodoxin]"}
{"X":50756,"RHEA_ID":55954,"compounds":"a mannosylinositol-1-phospho-N-acyl-sphingoid base + GDP + H(+) => GDP-alpha-D-mannose + inositol phosphoceramide"}
{"X":50757,"RHEA_ID":49229,"DIRECTION":"LR","MASTER_ID":49228,"metacyc":"RXN-8788","compounds":"all-trans-geranylgeranyl diphosphate + bacteriochlorophyllide a + H(+) => diphosphate + geranylgeranyl-bacteriochlorophyllide a"}
{"X":50758,"RHEA_ID":49230,"compounds":"diphosphate + geranylgeranyl-bacteriochlorophyllide a => all-trans-geranylgeranyl diphosphate + bacteriochlorophyllide a + H(+)"}
{"X":50759,"RHEA_ID":59302,"compounds":"adenosine 3',5'-bisphosphate + firefly D-sulfoluciferin + H(+) => 3'-phosphoadenylyl sulfate + firefly D-luciferin"}
{"X":50760,"RHEA_ID":59303,"compounds":"3'-phosphoadenylyl sulfate + firefly D-luciferin <=> adenosine 3',5'-bisphosphate + firefly D-sulfoluciferin + H(+)"}
{"X":50761,"RHEA_ID":49233,"DIRECTION":"LR","MASTER_ID":49232,"ecocyc":"TRANS-RXN-165","metacyc":"RXN-15087","compounds":"D-mannose(out) + N(pros)-phospho-L-histidyl-[protein] => D-mannose 6-phosphate(in) + L-histidyl-[protein]"}
{"X":50762,"RHEA_ID":49234,"compounds":"D-mannose 6-phosphate(in) + L-histidyl-[protein] => D-mannose(out) + N(pros)-phospho-L-histidyl-[protein]"}
{"X":50763,"RHEA_ID":59306,"compounds":"adenosine 3',5'-bisphosphate + firefly L-sulfoluciferin + H(+) => 3'-phosphoadenylyl sulfate + firefly L-luciferin"}
{"X":50764,"RHEA_ID":55962,"compounds":"AMP + diphosphate + gamma-butyrobetainyl-CoA => 4-(trimethylamino)butanoate + ATP + CoA"}
{"X":50765,"RHEA_ID":59308,"compounds":"D-galactono-1,5-lactone + H2O = D-galactonate + H(+)"}
{"X":50766,"RHEA_ID":49238,"compounds":"L-histidyl-[protein] + sucrose 6(G)-phosphate(in) => N(pros)-phospho-L-histidyl-[protein](out) + sucrose"}
{"X":50767,"RHEA_ID":59310,"compounds":"D-galactonate + H(+) => D-galactono-1,5-lactone + H2O"}
{"X":50768,"RHEA_ID":55966,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + GDP + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + GTP"}
{"X":50769,"RHEA_ID":59312,"DIRECTION":"UN","MASTER_ID":59312,"ec":"1.1.3.5","compounds":"D-galactose + O2 = D-galactono-1,5-lactone + H2O2"}
{"X":50770,"RHEA_ID":49242,"compounds":"L-histidyl-[protein] + N-acetyl-D-glucosamine 6-phosphate(in) => N(pros)-phospho-L-histidyl-[protein] + N-acetyl-D-glucosamine(out)"}
{"X":50771,"RHEA_ID":52625,"DIRECTION":"LR","MASTER_ID":52624,"metacyc":"RXN-15003","compounds":"[amino group carrier protein]-C-terminal-L-glutamate + ATP + L-glutamate => [amino group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ADP + H(+) + phosphate"}
{"X":50772,"RHEA_ID":52626,"compounds":"[amino group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ADP + H(+) + phosphate => [amino group carrier protein]-C-terminal-L-glutamate + ATP + L-glutamate"}
{"X":50773,"RHEA_ID":59316,"DIRECTION":"UN","MASTER_ID":59316,"ec":"1.1.3.5","compounds":"D-cellobiose + O2 = D-cellobiono-1,5-lactone + H2O2"}
{"X":50774,"RHEA_ID":49246,"compounds":"18-oxo-resolvin E1 + H(+) + NADH => NAD(+) + resolvin E1"}
{"X":50775,"RHEA_ID":49247,"compounds":"NAD(+) + resolvin E1 <=> 18-oxo-resolvin E1 + H(+) + NADH"}
{"X":50776,"RHEA_ID":55974,"compounds":"CoA + ethyl acetate => acetyl-CoA + ethanol"}
{"X":50777,"RHEA_ID":59320,"compounds":"D-cellobiono-1,5-lactone + H2O = 4-O-beta-D-glucopyranosyl-D-gluconate + H(+)"}
{"X":50778,"RHEA_ID":49250,"compounds":"galactitol 1-phosphate(in) + L-histidyl-[protein] => galactitol(out) + N(pros)-phospho-L-histidyl-[protein]"}
{"X":50779,"RHEA_ID":59322,"compounds":"4-O-beta-D-glucopyranosyl-D-gluconate + H(+) => D-cellobiono-1,5-lactone + H2O"}
{"X":50780,"RHEA_ID":50426,"compounds":"prostaglandin G1 => (8Z,11Z,14Z)-eicosatrienoate + 2 O2"}
{"X":50781,"RHEA_ID":59324,"compounds":"D-xylose + O2 = D-xylono-1,5-lactone + H2O2"}
{"X":50782,"RHEA_ID":49253,"DIRECTION":"LR","MASTER_ID":49252,"ecocyc":"TRANS-RXN0-582","metacyc":"RXN-15151","compounds":"D-fructose(out) + N(pros)-phospho-L-histidyl-[protein] => D-fructose 1-phosphate(in) + L-histidyl-[protein]"}
{"X":50783,"RHEA_ID":49254,"compounds":"D-fructose 1-phosphate(in) + L-histidyl-[protein] => D-fructose(out) + N(pros)-phospho-L-histidyl-[protein]"}
{"X":50784,"RHEA_ID":59327,"compounds":"D-xylose + O2 <=> D-xylono-1,5-lactone + H2O2"}
{"X":50785,"RHEA_ID":49257,"DIRECTION":"LR","MASTER_ID":49256,"metacyc":"RXN-14729","compounds":"2-amino-2-deoxy-D-gluconate(out) + N(pros)-phospho-L-histidyl-[protein] => 2-amino-2-deoxy-D-gluconate 6-phosphate(in) + L-histidyl-[protein]"}
{"X":50786,"RHEA_ID":49258,"compounds":"2-amino-2-deoxy-D-gluconate 6-phosphate(in) + L-histidyl-[protein] => 2-amino-2-deoxy-D-gluconate(out) + N(pros)-phospho-L-histidyl-[protein]"}
{"X":50787,"RHEA_ID":55986,"compounds":"(R)-prunasin + H(+) + UDP => (R)-mandelonitrile + UDP-alpha-D-glucose"}
{"X":50788,"RHEA_ID":53741,"compounds":"[Rab1 protein]-O(4)-(5'-adenylyl)-L-tyrosine + H2O => [Rab1 protein]-L-tyrosine + AMP + H(+)"}
{"X":50789,"RHEA_ID":49261,"DIRECTION":"LR","MASTER_ID":49260,"metacyc":"RXN-15169","compounds":"D-galactose(out) + N(pros)-phospho-L-histidyl-[protein] => D-galactose 6-phosphate(in) + L-histidyl-[protein]"}
{"X":50790,"RHEA_ID":49262,"compounds":"D-galactose 6-phosphate(in) + L-histidyl-[protein] => D-galactose(out) + N(pros)-phospho-L-histidyl-[protein]"}
{"X":50791,"RHEA_ID":55990,"compounds":"beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] => H2O + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein]"}
{"X":50792,"RHEA_ID":49264,"compounds":"5-O-[(E)-caffeoyl]-shikimate + H2O = (E)-caffeate + H(+) + shikimate"}
{"X":50793,"RHEA_ID":49265,"compounds":"5-O-[(E)-caffeoyl]-shikimate + H2O => (E)-caffeate + H(+) + shikimate"}
{"X":50794,"RHEA_ID":49266,"compounds":"(E)-caffeate + H(+) + shikimate => 5-O-[(E)-caffeoyl]-shikimate + H2O"}
{"X":50795,"RHEA_ID":59338,"compounds":"AH2 + demethylspheroidene => 1-hydroxy-all-trans-1,2-dihydro-neurosporene + A"}
{"X":50796,"RHEA_ID":55995,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)"}
{"X":50797,"RHEA_ID":49269,"compounds":"25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 23S,25-dihydroxy-24-oxocholecalciferol + H2O + 2 oxidized [adrenodoxin]"}
{"X":50798,"RHEA_ID":49270,"compounds":"23S,25-dihydroxy-24-oxocholecalciferol + H2O + 2 oxidized [adrenodoxin] => 25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}
{"X":50799,"RHEA_ID":49271,"compounds":"25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 23S,25-dihydroxy-24-oxocholecalciferol + H2O + 2 oxidized [adrenodoxin]"}
{"X":50800,"RHEA_ID":49273,"compounds":"alfacalcidol + O2 + reduced [NADPH--hemoprotein reductase] => calcitriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50801,"RHEA_ID":49274,"compounds":"calcitriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => alfacalcidol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":50802,"RHEA_ID":52656,"DIRECTION":"UN","MASTER_ID":52656,"ec":"1.1.1.211","compounds":"a long-chain (3S)-hydroxy fatty acyl-CoA + NAD(+) = a long-chain 3-oxo-fatty acyl-CoA + H(+) + NADH"}
{"X":50803,"RHEA_ID":49277,"compounds":"CTP + phytyl phosphate => CDP + phytyl diphosphate"}
{"X":50804,"RHEA_ID":49278,"compounds":"CDP + phytyl diphosphate => CTP + phytyl phosphate"}
{"X":50805,"RHEA_ID":49279,"compounds":"CTP + phytyl phosphate <=> CDP + phytyl diphosphate"}
{"X":50806,"RHEA_ID":49281,"DIRECTION":"LR","MASTER_ID":49280,"metacyc":"RXN-17504","compounds":"FADH2 + O2 + phenol => catechol + FAD + H(+) + H2O"}
{"X":50807,"RHEA_ID":49282,"compounds":"catechol + FAD + H(+) + H2O => FADH2 + O2 + phenol"}
{"X":50808,"RHEA_ID":52664,"DIRECTION":"UN","MASTER_ID":52664,"ec":"4.2.1.150","compounds":"a short-chain (3S)-hydroxyacyl-CoA = a short-chain (2E)-enoyl-CoA + H2O"}
{"X":50809,"RHEA_ID":49284,"DIRECTION":"UN","MASTER_ID":49284,"ec":"2.7.7.90","compounds":"8-amino-3,8-dideoxy-alpha-D-manno-octulosonate + CTP = CMP-8-amino-3,8-dideoxy-alpha-D-manno-oct-2-ulosonate + diphosphate"}
{"X":50810,"RHEA_ID":49285,"DIRECTION":"LR","MASTER_ID":49284,"metacyc":"RXN-16748","compounds":"8-amino-3,8-dideoxy-alpha-D-manno-octulosonate + CTP => CMP-8-amino-3,8-dideoxy-alpha-D-manno-oct-2-ulosonate + diphosphate"}
{"X":50811,"RHEA_ID":49286,"compounds":"CMP-8-amino-3,8-dideoxy-alpha-D-manno-oct-2-ulosonate + diphosphate => 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate + CTP"}
{"X":50812,"RHEA_ID":49287,"compounds":"8-amino-3,8-dideoxy-alpha-D-manno-octulosonate + CTP <=> CMP-8-amino-3,8-dideoxy-alpha-D-manno-oct-2-ulosonate + diphosphate"}
{"X":50813,"RHEA_ID":56015,"compounds":"H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) <=> beta-D-mannose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)"}
{"X":50814,"RHEA_ID":49289,"DIRECTION":"LR","MASTER_ID":49288,"ecocyc":"RXN-17127","metacyc":"RXN-17127","compounds":"(R)-lipoate + [lipoyl-carrier protein]-L-lysine + ATP => [lipoyl-carrier protein]-(R)-N(6)-lipoyl-L-lysine + AMP + diphosphate + H(+)"}
{"X":50815,"RHEA_ID":49290,"compounds":"[lipoyl-carrier protein]-(R)-N(6)-lipoyl-L-lysine + AMP + diphosphate + H(+) => (R)-lipoate + [lipoyl-carrier protein]-L-lysine + ATP"}
{"X":50816,"RHEA_ID":52672,"compounds":"2-oxoglutarate + [amino group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate = [amino group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + L-glutamate"}
{"X":50817,"RHEA_ID":49292,"DIRECTION":"UN","MASTER_ID":49292,"ec":"2.7.1.205","compounds":"D-cellobiose(out) + N(pros)-phospho-L-histidyl-[protein] = 6-phospho-beta-D-glucosyl-(1->4)-D-glucose(in) + L-histidyl-[protein]"}
{"X":50818,"RHEA_ID":49293,"DIRECTION":"LR","MASTER_ID":49292,"metacyc":"RXN-15086","compounds":"D-cellobiose(out) + N(pros)-phospho-L-histidyl-[protein] => 6-phospho-beta-D-glucosyl-(1->4)-D-glucose(in) + L-histidyl-[protein]"}
{"X":50819,"RHEA_ID":49294,"compounds":"6-phospho-beta-D-glucosyl-(1->4)-D-glucose(in) + L-histidyl-[protein] => D-cellobiose(out) + N(pros)-phospho-L-histidyl-[protein]"}
{"X":50820,"RHEA_ID":52676,"DIRECTION":"UN","MASTER_ID":52676,"ec":"3.5.1.132","compounds":"[amino group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + H2O = [amino group carrier protein]-C-terminal-L-glutamate + L-ornithine"}
{"X":50821,"RHEA_ID":59367,"compounds":"1-octadecanoyl-2-(9,10-epoxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphoserine + 9,10-epoxyoctadecanoate + H(+)"}
{"X":50822,"RHEA_ID":49297,"DIRECTION":"LR","MASTER_ID":49296,"metacyc":"RXN-15172","compounds":"keto-L-sorbose(out) + N(pros)-phospho-L-histidyl-[protein] => L-histidyl-[protein] + L-sorbose 1-phosphate(in)"}
{"X":50823,"RHEA_ID":49298,"compounds":"L-histidyl-[protein] + L-sorbose 1-phosphate(in) => keto-L-sorbose(out) + N(pros)-phospho-L-histidyl-[protein]"}
{"X":50824,"RHEA_ID":59370,"compounds":"1-octadecanoyl-sn-glycero-3-phosphoserine + 10-hydroxyoctadecanoate + H(+) => 1-octadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O"}
{"X":50825,"RHEA_ID":56027,"compounds":"H2O + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)"}
{"X":50826,"RHEA_ID":49301,"compounds":"D-maltose(out) + N(pros)-phospho-L-histidyl-[protein] => alpha-maltose 6'-phosphate(in) + L-histidyl-[protein]"}
{"X":50827,"RHEA_ID":49302,"compounds":"alpha-maltose 6'-phosphate(in) + L-histidyl-[protein] => D-maltose(out) + N(pros)-phospho-L-histidyl-[protein]"}
{"X":50828,"RHEA_ID":59374,"compounds":"1-hexadecanoyl-sn-glycero-3-phospho-L-serine + 10-hydroxyoctadecanoate + H(+) => 1-hexadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O"}
{"X":50829,"RHEA_ID":56031,"compounds":"3 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) <=> 3 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)"}
{"X":50830,"RHEA_ID":49305,"compounds":"H2O + N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphinganine => a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + N-acetyl-alpha-D-galactosamine"}
{"X":50831,"RHEA_ID":49306,"compounds":"a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + N-acetyl-alpha-D-galactosamine => H2O + N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphinganine"}
{"X":50832,"RHEA_ID":49307,"compounds":"H2O + N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphinganine <=> a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + N-acetyl-alpha-D-galactosamine"}
{"X":50833,"RHEA_ID":52689,"compounds":"3-phenyllactate + NAD(+) => 3-phenylpyruvate + H(+) + NADH"}
{"X":50834,"RHEA_ID":49309,"compounds":"a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O => a neolactoside nLc4Cer(d18:0) + L-fucose"}
{"X":50835,"RHEA_ID":49310,"compounds":"a neolactoside nLc4Cer(d18:0) + L-fucose => a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O"}
{"X":50836,"RHEA_ID":49311,"compounds":"a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O <=> a neolactoside nLc4Cer(d18:0) + L-fucose"}
{"X":50837,"RHEA_ID":56039,"compounds":"H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3)"}
{"X":50838,"RHEA_ID":49313,"compounds":"2-trans,4-trans-xanthoxin + NAD(+) => 2-trans-(+)-abscisic aldehyde + H(+) + NADH"}
{"X":50839,"RHEA_ID":49314,"compounds":"2-trans-(+)-abscisic aldehyde + H(+) + NADH => 2-trans,4-trans-xanthoxin + NAD(+)"}
{"X":50840,"RHEA_ID":49315,"compounds":"2-trans,4-trans-xanthoxin + NAD(+) <=> 2-trans-(+)-abscisic aldehyde + H(+) + NADH"}
{"X":50841,"RHEA_ID":52697,"DIRECTION":"LR","MASTER_ID":52696,"metacyc":"RXN-18054","compounds":"a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-galactose => a 1,2-diacyl-3-O-[alpha-D-galactopyranosyl-(1->2)-alpha-D-glucopyranosyl]-sn-glycerol + H(+) + UDP"}
{"X":50842,"RHEA_ID":49317,"compounds":"beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (5R,6S)-5,6-epoxi-beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":50843,"RHEA_ID":49318,"compounds":"(5R,6S)-5,6-epoxi-beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":50844,"RHEA_ID":49319,"compounds":"beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (5R,6S)-5,6-epoxi-beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":50845,"RHEA_ID":56047,"compounds":"H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B3)"}
{"X":50846,"RHEA_ID":49321,"compounds":"all-trans-violaxanthin => (5R,6S)-5,6-epoxi-capsanthin"}
{"X":50847,"RHEA_ID":49322,"compounds":"(5R,6S)-5,6-epoxi-capsanthin => all-trans-violaxanthin"}
{"X":50848,"RHEA_ID":49323,"compounds":"all-trans-violaxanthin <=> (5R,6S)-5,6-epoxi-capsanthin"}
{"X":50849,"RHEA_ID":59395,"compounds":"acetyl-CoA + L-seryl-[protein] <=> CoA + O-acetyl-L-seryl-[protein]"}
{"X":50850,"RHEA_ID":49325,"compounds":"(5R,6S)-5,6-epoxi-capsanthin => all-trans-capsorubin"}
{"X":50851,"RHEA_ID":59397,"compounds":"L-leucine => D-leucine"}
{"X":50852,"RHEA_ID":49327,"compounds":"(5R,6S)-5,6-epoxi-capsanthin <=> all-trans-capsorubin"}
{"X":50853,"RHEA_ID":59399,"compounds":"L-leucine <=> D-leucine"}
{"X":50854,"RHEA_ID":56056,"DIRECTION":"UN","MASTER_ID":56056,"ec":"2.4.1.170","compounds":"genistein + UDP-alpha-D-glucose = genistein 7-O-beta-D-glucoside + H(+) + UDP"}
{"X":50855,"RHEA_ID":59401,"compounds":"L-2-aminohexanoate => D-2-aminohexanoate"}
{"X":50856,"RHEA_ID":49331,"compounds":"2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spheroidene <=> 2-hydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":50857,"RHEA_ID":59403,"compounds":"L-2-aminohexanoate <=> D-2-aminohexanoate"}
{"X":50858,"RHEA_ID":49333,"DIRECTION":"LR","MASTER_ID":49332,"metacyc":"RXN-15624","compounds":"2-hydroxyspheroidene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2,2-dihydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":50859,"RHEA_ID":49334,"compounds":"2,2-dihydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-hydroxyspheroidene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":50860,"RHEA_ID":49335,"compounds":"2-hydroxyspheroidene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2,2-dihydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":50861,"RHEA_ID":49336,"compounds":"2,2-dihydroxyspheroidene = H2O + spheroiden-2-one"}
{"X":50862,"RHEA_ID":49337,"DIRECTION":"LR","MASTER_ID":49336,"metacyc":"RXN-15625","compounds":"2,2-dihydroxyspheroidene => H2O + spheroiden-2-one"}
{"X":50863,"RHEA_ID":59409,"DIRECTION":"LR","MASTER_ID":59408,"metacyc":"RXN-13680","reactome":"R-HSA-5691507.2","compounds":"H2O + N-acetyl-L-aspartate => acetate + L-aspartate"}
{"X":50864,"RHEA_ID":49339,"compounds":"2,2-dihydroxyspheroidene <=> H2O + spheroiden-2-one"}
{"X":50865,"RHEA_ID":49340,"compounds":"2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin = 2-hydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":50866,"RHEA_ID":49341,"DIRECTION":"LR","MASTER_ID":49340,"metacyc":"RXN-15626","compounds":"2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin => 2-hydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":50867,"RHEA_ID":59413,"DIRECTION":"LR","MASTER_ID":59412,"metacyc":"RXN-6562","compounds":"2-oxosuccinamate + H2O => NH4(+) + oxaloacetate"}
{"X":50868,"RHEA_ID":49343,"compounds":"2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin <=> 2-hydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":50869,"RHEA_ID":59414,"compounds":"NH4(+) + oxaloacetate => 2-oxosuccinamate + H2O"}
{"X":50870,"RHEA_ID":49345,"DIRECTION":"LR","MASTER_ID":49344,"metacyc":"RXN-15627","compounds":"2-hydroxyspirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2,2-dihydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":50871,"RHEA_ID":49346,"compounds":"2,2-dihydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-hydroxyspirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":50872,"RHEA_ID":49347,"compounds":"2-hydroxyspirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2,2-dihydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":50873,"RHEA_ID":52733,"DIRECTION":"LR","MASTER_ID":52732,"metacyc":"RXN-10453","compounds":"3'-phosphoadenylyl sulfate + an 11-hydroxyjasmonate => adenosine 3',5'-bisphosphate + an 11-sulfojasmonate + H(+)"}
{"X":50874,"RHEA_ID":49349,"DIRECTION":"LR","MASTER_ID":49348,"metacyc":"RXN-15628","compounds":"2,2-dihydroxyspirilloxanthin => 2-oxospirilloxanthin + H2O"}
{"X":50875,"RHEA_ID":49350,"compounds":"2-oxospirilloxanthin + H2O => 2,2-dihydroxyspirilloxanthin"}
{"X":50876,"RHEA_ID":49351,"compounds":"2,2-dihydroxyspirilloxanthin <=> 2-oxospirilloxanthin + H2O"}
{"X":50877,"RHEA_ID":49352,"compounds":"2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2'-hydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":50878,"RHEA_ID":49353,"DIRECTION":"LR","MASTER_ID":49352,"metacyc":"RXN-15629","compounds":"2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2'-hydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":50879,"RHEA_ID":49354,"compounds":"2'-hydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":50880,"RHEA_ID":49355,"compounds":"2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2'-hydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":50881,"RHEA_ID":49356,"compounds":"2'-hydroxy-2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2',2'-dihydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":50882,"RHEA_ID":49357,"DIRECTION":"LR","MASTER_ID":49356,"metacyc":"RXN-15630","compounds":"2'-hydroxy-2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2',2'-dihydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":50883,"RHEA_ID":59437,"compounds":"4-amino-L-phenylalanine + ATP + holo-[peptidyl-carrier protein] => 4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AMP + diphosphate"}
{"X":50884,"RHEA_ID":49359,"compounds":"2'-hydroxy-2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2',2'-dihydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":50885,"RHEA_ID":49360,"compounds":"2',2'-dihydroxy-2-oxospirilloxanthin = 2,2'-dioxospirilloxanthin + H2O"}
{"X":50886,"RHEA_ID":49361,"DIRECTION":"LR","MASTER_ID":49360,"metacyc":"RXN-15631","compounds":"2',2'-dihydroxy-2-oxospirilloxanthin => 2,2'-dioxospirilloxanthin + H2O"}
{"X":50887,"RHEA_ID":59441,"DIRECTION":"LR","MASTER_ID":59440,"metacyc":"RXN-20203","compounds":"(-)-dehydrodiconiferyl alcohol + H(+) + NADPH => (S)-isodihydrodehydrodiconiferyl alcohol + NADP(+)"}
{"X":50888,"RHEA_ID":52748,"compounds":"alpha-isomaltosyl-(1->3)-isomaltose + H2O = 2 isomaltose"}
{"X":50889,"RHEA_ID":49364,"compounds":"17-(4-hydroxyphenyl)heptadecanoate + ATP + H(+) = 17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + diphosphate"}
{"X":50890,"RHEA_ID":59445,"compounds":"1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene + A => 1,1'-dihydroxy-3,4-didehydro-1,2-dihydrolycopene + AH2"}
{"X":50891,"RHEA_ID":59446,"compounds":"1,1'-dihydroxy-3,4-didehydro-1,2-dihydrolycopene + AH2 => 1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene + A"}
{"X":50892,"RHEA_ID":49368,"compounds":"19-(4-hydroxyphenyl)nonadecanoate + ATP + H(+) = 19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + diphosphate"}
{"X":50893,"RHEA_ID":56095,"compounds":"bilirubin IXalpha + H(+) + oxidized coenzyme F420-(gamma-Glu)(n) <=> biliverdin IXalpha + reduced coenzyme F420-(gamma-Glu)(n)"}
{"X":50894,"RHEA_ID":59449,"compounds":"dodecan-1-ol + NADP(+) => dodecanal + H(+) + NADPH"}
{"X":50895,"RHEA_ID":59450,"compounds":"dodecanal + H(+) + NADPH => dodecan-1-ol + NADP(+)"}
{"X":50896,"RHEA_ID":49372,"DIRECTION":"UN","MASTER_ID":49372,"ec":"1.14.13.217","compounds":"H(+) + NADH + O2 + protodeoxyviolaceinate = H2O + NAD(+) + protoviolaceinate"}
{"X":50897,"RHEA_ID":49373,"DIRECTION":"LR","MASTER_ID":49372,"metacyc":"RXN-13341","compounds":"H(+) + NADH + O2 + protodeoxyviolaceinate => H2O + NAD(+) + protoviolaceinate"}
{"X":50898,"RHEA_ID":49374,"compounds":"H2O + NAD(+) + protoviolaceinate => H(+) + NADH + O2 + protodeoxyviolaceinate"}
{"X":50899,"RHEA_ID":52760,"DIRECTION":"UN","MASTER_ID":52760,"ec":"3.4.19.16","compounds":"(Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O = (Z)-1-(glycyl-L-cystein-S-yl)-2-phenylacetohydroximate + L-glutamate"}
{"X":50900,"RHEA_ID":49376,"compounds":"12-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 12,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50901,"RHEA_ID":52762,"compounds":"(Z)-1-(glycyl-L-cystein-S-yl)-2-phenylacetohydroximate + L-glutamate => (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O"}
{"X":50902,"RHEA_ID":59457,"compounds":"NADP(+) + tetradecan-1-ol => H(+) + NADPH + tetradecanal"}
{"X":50903,"RHEA_ID":52764,"DIRECTION":"UN","MASTER_ID":52764,"ec":"3.4.19.16","compounds":"(E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O = (E)-1-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetohydroximate + L-glutamate"}
{"X":50904,"RHEA_ID":49380,"compounds":"5-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 5,20-dihydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50905,"RHEA_ID":52766,"compounds":"(E)-1-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetohydroximate + L-glutamate => (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O"}
{"X":50906,"RHEA_ID":49382,"compounds":"5,20-dihydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 5-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":50907,"RHEA_ID":52768,"DIRECTION":"UN","MASTER_ID":52768,"ec":"3.4.19.16","compounds":"2-(glutathion-S-yl)-2-(1H-indol-3-yl)acetonitrile + H2O = 2-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetonitrile + L-glutamate"}
{"X":50908,"RHEA_ID":59462,"compounds":"H(+) + hexadecanal + NADPH => hexadecan-1-ol + NADP(+)"}
{"X":50909,"RHEA_ID":52770,"compounds":"2-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetonitrile + L-glutamate => 2-(glutathion-S-yl)-2-(1H-indol-3-yl)acetonitrile + H2O"}
{"X":50910,"RHEA_ID":59465,"compounds":"NADP(+) + octadecan-1-ol => H(+) + NADPH + octadecanal"}
{"X":50911,"RHEA_ID":52772,"DIRECTION":"UN","MASTER_ID":52772,"ec":"4.1.2.60","compounds":"7,8-dihydroneopterin 3'-triphosphate = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde triphosphate"}
{"X":50912,"RHEA_ID":49388,"DIRECTION":"UN","MASTER_ID":49388,"ec":"2.4.1.338","compounds":"UDP-alpha-D-glucose + validoxylamine A = H(+) + UDP + validamycin A"}
{"X":50913,"RHEA_ID":59467,"compounds":"NADP(+) + octadecan-1-ol <=> H(+) + NADPH + octadecanal"}
{"X":50914,"RHEA_ID":59469,"DIRECTION":"LR","MASTER_ID":59468,"metacyc":"RXN-6641","compounds":"an S-substituted glutathione + H2O => an S-substitued L-cysteinylglycine + L-glutamate"}
{"X":50915,"RHEA_ID":59470,"compounds":"an S-substitued L-cysteinylglycine + L-glutamate => an S-substituted glutathione + H2O"}
{"X":50916,"RHEA_ID":49392,"compounds":"20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 20S,23,24-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]"}
{"X":50917,"RHEA_ID":52778,"compounds":"camalexin + CO2 + 2 H(+) + 4 H2O + hydrogen cyanide + 2 oxidized [NADPH--hemoprotein reductase] => 2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}
{"X":50918,"RHEA_ID":49394,"compounds":"20S,23,24-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin] => 20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}
{"X":50919,"RHEA_ID":49395,"compounds":"20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 20S,23,24-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]"}
{"X":50920,"RHEA_ID":49396,"compounds":"20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 20S,23,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]"}
{"X":50921,"RHEA_ID":60730,"compounds":"3,7-dimethylocta-2,6-dienoate + 2 H(+) + NADPH => citral + H2O + NADP(+)"}
{"X":50922,"RHEA_ID":59477,"compounds":"2 AH2 + 2 ATP + benzoate + L-phenylalanine => 2 A + 2 AMP + 2 diphosphate + H(+) + N-benzoyl-L-phenylalaninol"}
{"X":50923,"RHEA_ID":52784,"compounds":"2-sulfenohercynine + AH2 + H(+) = A + ergothioneine + H2O"}
{"X":50924,"RHEA_ID":49400,"DIRECTION":"UN","MASTER_ID":49400,"ec":"3.1.3.101","compounds":"H2O + validoxylamine A 7'-phosphate = phosphate + validoxylamine A"}
{"X":50925,"RHEA_ID":52786,"compounds":"A + ergothioneine + H2O => 2-sulfenohercynine + AH2 + H(+)"}
{"X":50926,"RHEA_ID":59485,"DIRECTION":"LR","MASTER_ID":59484,"metacyc":"RXN-12586","compounds":"2 [Fe(III)cytochrome c] + arsenite + H2O => 2 [Fe(II)cytochrome c] + arsenate + 3 H(+)"}
{"X":50927,"RHEA_ID":52788,"DIRECTION":"UN","MASTER_ID":52788,"ec":"4.99.1.10","compounds":"chlorophyll a + 2 H(+) = Mg(2+) + pheophytin a"}
{"X":50928,"RHEA_ID":49404,"DIRECTION":"UN","MASTER_ID":49404,"ec":"2.4.1.339","compounds":"beta-D-mannopyranosyl-(1->2)-D-mannopyranose + phosphate = alpha-D-mannose 1-phosphate + D-mannose"}
{"X":50929,"RHEA_ID":49405,"compounds":"beta-D-mannopyranosyl-(1->2)-D-mannopyranose + phosphate => alpha-D-mannose 1-phosphate + D-mannose"}
{"X":50930,"RHEA_ID":49406,"compounds":"alpha-D-mannose 1-phosphate + D-mannose => beta-D-mannopyranosyl-(1->2)-D-mannopyranose + phosphate"}
{"X":50931,"RHEA_ID":52792,"DIRECTION":"UN","MASTER_ID":52792,"ec":"4.99.1.10","compounds":"chlorophyllide a + 2 H(+) = Mg(2+) + pheophorbide a"}
{"X":50932,"RHEA_ID":49408,"DIRECTION":"UN","MASTER_ID":49408,"ec":"2.4.1.340","compounds":"[(1->2)-beta-D-mannosyl](n) + phosphate = [(1->2)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate"}
{"X":50933,"RHEA_ID":59491,"compounds":"ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol <=> ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol"}
{"X":50934,"RHEA_ID":59493,"compounds":"(2E)-geranyl diphosphate + L-tryptophyl-[protein] => 3-geranyl-2S,3R-dihydro-N-cyclo-L-tryptophyl-[protein] + diphosphate"}
{"X":50935,"RHEA_ID":52796,"DIRECTION":"UN","MASTER_ID":52796,"ec":"4.99.1.11","compounds":"2 H(+) + Ni-sirohydrochlorin = Ni(2+) + sirohydrochlorin"}
{"X":50936,"RHEA_ID":49412,"DIRECTION":"UN","MASTER_ID":49412,"ec":"2.4.1.341","compounds":"beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-colitose = alpha-L-colitosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP + H(+)"}
{"X":50937,"RHEA_ID":59495,"compounds":"(2E)-geranyl diphosphate + L-tryptophyl-[protein] <=> 3-geranyl-2S,3R-dihydro-N-cyclo-L-tryptophyl-[protein] + diphosphate"}
{"X":50938,"RHEA_ID":59497,"compounds":"(20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + O2 + reduced [NADPH--hemoprotein reductase] => (20S)-ginsenoside C-K + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":50939,"RHEA_ID":52800,"DIRECTION":"UN","MASTER_ID":52800,"ec":"6.3.2.50","compounds":"acetoacetyl-CoA + ATP + L-isoleucine = AMP + CoA + diphosphate + 2 H(+) + tenuazonic acid"}
{"X":50940,"RHEA_ID":49416,"DIRECTION":"UN","MASTER_ID":49416,"ec":"2.7.1.212","compounds":"ADP + alpha-D-ribose 1-phosphate = alpha-D-ribose 1,5-bisphosphate + AMP + H(+)"}
{"X":50941,"RHEA_ID":52802,"compounds":"AMP + CoA + diphosphate + 2 H(+) + tenuazonic acid => acetoacetyl-CoA + ATP + L-isoleucine"}
{"X":50942,"RHEA_ID":49418,"compounds":"alpha-D-ribose 1,5-bisphosphate + AMP + H(+) => ADP + alpha-D-ribose 1-phosphate"}
{"X":50943,"RHEA_ID":56145,"DIRECTION":"LR","MASTER_ID":56144,"metacyc":"RXN-11236","compounds":"a quinol + nitrate => a quinone + H2O + nitrite"}
{"X":50944,"RHEA_ID":49420,"DIRECTION":"UN","MASTER_ID":49420,"ec":"2.7.1.214","compounds":"ATP + valienone = ADP + H(+) + valienone 7-phosphate"}
{"X":50945,"RHEA_ID":52806,"compounds":"(+)-eremophilene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":50946,"RHEA_ID":59505,"compounds":"cholesterol + glycyl-L-cysteinyl-[protein] + H(+) => [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein]"}
{"X":50947,"RHEA_ID":52808,"DIRECTION":"UN","MASTER_ID":52808,"ec":"2.1.1.346","compounds":"adenosine in U6 snRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine in U6 snRNA + S-adenosyl-L-homocysteine"}
{"X":50948,"RHEA_ID":49424,"DIRECTION":"UN","MASTER_ID":49424,"ec":"2.7.1.214","compounds":"ATP + validone = ADP + H(+) + validone 7-phosphate"}
{"X":50949,"RHEA_ID":49425,"DIRECTION":"LR","MASTER_ID":49424,"metacyc":"RXN-9145","compounds":"ATP + validone => ADP + H(+) + validone 7-phosphate"}
{"X":50950,"RHEA_ID":59509,"compounds":"fumarate + L-cysteinyl-[protein] => S-(2-succinyl)-L-cysteinyl-[protein]"}
{"X":50951,"RHEA_ID":56153,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphocholine => (9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":50952,"RHEA_ID":49428,"DIRECTION":"UN","MASTER_ID":49428,"ec":"2.7.7.93","compounds":"CTP + phosphonoformate = CMP-5'-phosphonoformate + diphosphate"}
{"X":50953,"RHEA_ID":49429,"DIRECTION":"LR","MASTER_ID":49428,"metacyc":"RXN-10834","compounds":"CTP + phosphonoformate => CMP-5'-phosphonoformate + diphosphate"}
{"X":50954,"RHEA_ID":59513,"compounds":"acetylsalicylate + L-seryl-[protein] => O-acetyl-L-seryl-[protein] + salicylate"}
{"X":50955,"RHEA_ID":56157,"compounds":"(12R)-hydroxy-(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine => (12R-hydroxy-9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":50956,"RHEA_ID":49432,"DIRECTION":"UN","MASTER_ID":49432,"ec":"2.8.3.25","compounds":"cholate + lithocholoyl-CoA = choloyl-CoA + lithocholate"}
{"X":50957,"RHEA_ID":49433,"compounds":"cholate + lithocholoyl-CoA => choloyl-CoA + lithocholate"}
{"X":50958,"RHEA_ID":59517,"compounds":"acetylsalicylate + L-lysyl-[protein] => H(+) + N(6)-acetyl-L-lysyl-[protein] + salicylate"}
{"X":50959,"RHEA_ID":49435,"DIRECTION":"BI","MASTER_ID":49432,"metacyc":"RXN-17406","compounds":"cholate + lithocholoyl-CoA <=> choloyl-CoA + lithocholate"}
{"X":50960,"RHEA_ID":49436,"DIRECTION":"UN","MASTER_ID":49436,"ec":"2.8.3.25","compounds":"cholate + deoxycholoyl-CoA = choloyl-CoA + deoxycholate"}
{"X":50961,"RHEA_ID":49437,"DIRECTION":"LR","MASTER_ID":49436,"metacyc":"RXN-15366","compounds":"cholate + deoxycholoyl-CoA => choloyl-CoA + deoxycholate"}
{"X":50962,"RHEA_ID":49438,"compounds":"choloyl-CoA + deoxycholate => cholate + deoxycholoyl-CoA"}
{"X":50963,"RHEA_ID":59522,"compounds":"(2S)-ethylmalonyl-CoA + ADP + H(+) + phosphate => ATP + butanoyl-CoA + hydrogencarbonate"}
{"X":50964,"RHEA_ID":49440,"DIRECTION":"UN","MASTER_ID":49440,"ec":"2.8.3.24","compounds":"(R)-2-hydroxy-4-methylpentanoate + 4-methylpentanoyl-CoA = (R)-2-hydroxy-4-methylpentanoyl-CoA + 4-methylpentanoate"}
{"X":50965,"RHEA_ID":49441,"DIRECTION":"LR","MASTER_ID":49440,"metacyc":"RXN-16246","compounds":"(R)-2-hydroxy-4-methylpentanoate + 4-methylpentanoyl-CoA => (R)-2-hydroxy-4-methylpentanoyl-CoA + 4-methylpentanoate"}
{"X":50966,"RHEA_ID":49442,"compounds":"(R)-2-hydroxy-4-methylpentanoyl-CoA + 4-methylpentanoate => (R)-2-hydroxy-4-methylpentanoate + 4-methylpentanoyl-CoA"}
{"X":50967,"RHEA_ID":59526,"compounds":"9-O-10-oxo-(12Z)-octadecenoate L-aspartatyl ester-[protein] => 9S,10-epoxy-(10,12Z)-octadecadienoate + H(+) + L-aspartyl-[protein]"}
{"X":50968,"RHEA_ID":50616,"compounds":"NADP(+) + nonan-2-one = (3E)-3-nonen-2-one + H(+) + NADPH"}
{"X":50969,"RHEA_ID":49445,"DIRECTION":"LR","MASTER_ID":49444,"metacyc":"RXN-17703","compounds":"(2-aminobenzoyl)acetyl-CoA + H2O => (2-aminobenzoyl)acetate + CoA + H(+)"}
{"X":50970,"RHEA_ID":49446,"compounds":"(2-aminobenzoyl)acetate + CoA + H(+) => (2-aminobenzoyl)acetyl-CoA + H2O"}
{"X":50971,"RHEA_ID":52832,"compounds":"1-hydroxylimonen-2-one + H(+) + NADPH + O2 = 7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)"}
{"X":50972,"RHEA_ID":50620,"DIRECTION":"UN","MASTER_ID":50620,"ec":"2.4.1.343","compounds":"N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UDP-alpha-D-galactose = alpha-D-Gal-(1->3)-alpha-D-GlcNAc-diphospho-di-trans,octa-cis-undecaprenol + H(+) + UDP"}
{"X":50973,"RHEA_ID":49449,"compounds":"beta-D-Manp-(1->2)-beta-D-Manp-(1->2)-D-Manp + H2O => alpha-D-mannopyranose + beta-D-mannopyranosyl-(1->2)-D-mannopyranose"}
{"X":50974,"RHEA_ID":49450,"compounds":"alpha-D-mannopyranose + beta-D-mannopyranosyl-(1->2)-D-mannopyranose => beta-D-Manp-(1->2)-beta-D-Manp-(1->2)-D-Manp + H2O"}
{"X":50975,"RHEA_ID":59533,"compounds":"(S)-reticuline + S-adenosyl-L-methionine => (S)-codamine + H(+) + S-adenosyl-L-homocysteine"}
{"X":50976,"RHEA_ID":49452,"DIRECTION":"UN","MASTER_ID":49452,"ec":"3.2.1.199","compounds":"a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H2O = 6-sulfo-D-quinovose + a 1,2-diacyl-sn-glycerol"}
{"X":50977,"RHEA_ID":49453,"DIRECTION":"LR","MASTER_ID":49452,"metacyc":"RXN-17700","compounds":"a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H2O => 6-sulfo-D-quinovose + a 1,2-diacyl-sn-glycerol"}
{"X":50978,"RHEA_ID":49454,"compounds":"6-sulfo-D-quinovose + a 1,2-diacyl-sn-glycerol => a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H2O"}
{"X":50979,"RHEA_ID":59538,"compounds":"(2R)-ethylmalonyl-CoA + ADP + H(+) + phosphate => ATP + butanoyl-CoA + hydrogencarbonate"}
{"X":50980,"RHEA_ID":50628,"compounds":"a 2-(omega-methylsulfanyl)alkylmalate = a 3-(omega-methylsulfanyl)alkylmalate"}
{"X":50981,"RHEA_ID":49457,"DIRECTION":"LR","MASTER_ID":49456,"metacyc":"RXN-9030","compounds":"(2S)-2-amino-4-deoxychorismate + H2O => (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate + pyruvate"}
{"X":50982,"RHEA_ID":49458,"compounds":"(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate + pyruvate => (2S)-2-amino-4-deoxychorismate + H2O"}
{"X":50983,"RHEA_ID":59542,"compounds":"butanoyl-CoA + CO2 => (2R)-ethylmalonyl-CoA + H(+)"}
{"X":50984,"RHEA_ID":49460,"DIRECTION":"UN","MASTER_ID":49460,"ec":"3.5.99.11","compounds":"(2Z,4E)-2-aminomuconate + H2O = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NH4(+)"}
{"X":50985,"RHEA_ID":49461,"compounds":"(2Z,4E)-2-aminomuconate + H2O => (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NH4(+)"}
{"X":50986,"RHEA_ID":49462,"compounds":"(2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NH4(+) => (2Z,4E)-2-aminomuconate + H2O"}
{"X":50987,"RHEA_ID":56189,"DIRECTION":"LR","MASTER_ID":56188,"metacyc":"2.4.1.148-RXN","compounds":"3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP"}
{"X":50988,"RHEA_ID":49464,"DIRECTION":"UN","MASTER_ID":49464,"ec":"4.1.1.103","compounds":"2,6-dihydroxybenzoate + H(+) = CO2 + resorcinol"}
{"X":50989,"RHEA_ID":49465,"compounds":"2,6-dihydroxybenzoate + H(+) => CO2 + resorcinol"}
{"X":50990,"RHEA_ID":49466,"compounds":"CO2 + resorcinol => 2,6-dihydroxybenzoate + H(+)"}
{"X":50991,"RHEA_ID":56193,"DIRECTION":"LR","MASTER_ID":56192,"metacyc":"2.4.1.148-RXN","compounds":"3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP"}
{"X":50992,"RHEA_ID":49468,"compounds":"a 1,2-diacyl-sn-glycerol + UDP-alpha-D-6-sulfoquinovose = a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H(+) + UDP"}
{"X":50993,"RHEA_ID":49469,"DIRECTION":"LR","MASTER_ID":49468,"metacyc":"RXN-1224","compounds":"a 1,2-diacyl-sn-glycerol + UDP-alpha-D-6-sulfoquinovose => a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H(+) + UDP"}
{"X":50994,"RHEA_ID":49470,"compounds":"a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H(+) + UDP => a 1,2-diacyl-sn-glycerol + UDP-alpha-D-6-sulfoquinovose"}
{"X":50995,"RHEA_ID":59554,"compounds":"H2O2 + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone => N,N',N'',N'''-tetraacetylchitotetraose + O2"}
{"X":50996,"RHEA_ID":49472,"DIRECTION":"UN","MASTER_ID":49472,"ec":"2.4.2.58","compounds":"trans-4-hydroxy-L-prolyl-[protein] + UDP-beta-L-arabinofuranose = H(+) + O-(beta-L-arabinofuranosyl)-trans-4-hydroxy-L-prolyl-[protein] + UDP"}
{"X":50997,"RHEA_ID":49473,"compounds":"trans-4-hydroxy-L-prolyl-[protein] + UDP-beta-L-arabinofuranose => H(+) + O-(beta-L-arabinofuranosyl)-trans-4-hydroxy-L-prolyl-[protein] + UDP"}
{"X":50998,"RHEA_ID":49474,"compounds":"H(+) + O-(beta-L-arabinofuranosyl)-trans-4-hydroxy-L-prolyl-[protein] + UDP => trans-4-hydroxy-L-prolyl-[protein] + UDP-beta-L-arabinofuranose"}
{"X":50999,"RHEA_ID":49475,"DIRECTION":"BI","MASTER_ID":49472,"metacyc":"RXN-15011","compounds":"trans-4-hydroxy-L-prolyl-[protein] + UDP-beta-L-arabinofuranose <=> H(+) + O-(beta-L-arabinofuranosyl)-trans-4-hydroxy-L-prolyl-[protein] + UDP"}
{"X":51000,"RHEA_ID":49476,"compounds":"2 H2O + L-1-piperideine-6-carboxylate + NAD(+) = H(+) + L-2-aminoadipate + NADH"}
{"X":51001,"RHEA_ID":59560,"compounds":"H2O + N,N',N''-triacetylchitotriono-1,5-lactone = H(+) + N,N',N''-triacetylchitotrionate"}
{"X":51002,"RHEA_ID":49477,"DIRECTION":"LR","MASTER_ID":49476,"metacyc":"RXN-8162","compounds":"2 H2O + L-1-piperideine-6-carboxylate + NAD(+) => H(+) + L-2-aminoadipate + NADH"}
{"X":51003,"RHEA_ID":56205,"DIRECTION":"LR","MASTER_ID":56204,"metacyc":"2.4.99.4-RXN","compounds":"CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] => 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + CMP + H(+)"}
{"X":51004,"RHEA_ID":59563,"compounds":"H2O + N,N',N''-triacetylchitotriono-1,5-lactone <=> H(+) + N,N',N''-triacetylchitotrionate"}
{"X":51005,"RHEA_ID":49480,"compounds":"2 H2O + L-1-piperideine-6-carboxylate + NADP(+) = H(+) + L-2-aminoadipate + NADPH"}
{"X":51006,"RHEA_ID":49481,"DIRECTION":"LR","MASTER_ID":49480,"metacyc":"RXN-10855","compounds":"2 H2O + L-1-piperideine-6-carboxylate + NADP(+) => H(+) + L-2-aminoadipate + NADPH"}
{"X":51007,"RHEA_ID":49482,"compounds":"H(+) + L-2-aminoadipate + NADPH => 2 H2O + L-1-piperideine-6-carboxylate + NADP(+)"}
{"X":51008,"RHEA_ID":59567,"compounds":"H2O + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone <=> H(+) + N,N',N'',N'''-tetraacetylchitotetraonate"}
{"X":51009,"RHEA_ID":49484,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(in) + ATP + H2O = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate"}
{"X":51010,"RHEA_ID":49485,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(in) + ATP + H2O => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate"}
{"X":51011,"RHEA_ID":52872,"compounds":"17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":51012,"RHEA_ID":49487,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(in) + ATP + H2O <=> 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate"}
{"X":51013,"RHEA_ID":49488,"DIRECTION":"UN","MASTER_ID":49488,"ec":"4.2.1.168","compounds":"GDP-4-dehydro-alpha-D-rhamnose + L-glutamate = 2-oxoglutarate + GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+)"}
{"X":51014,"RHEA_ID":49489,"compounds":"GDP-4-dehydro-alpha-D-rhamnose + L-glutamate => 2-oxoglutarate + GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+)"}
{"X":51015,"RHEA_ID":52876,"compounds":"16beta,17beta-estriol + UDP-alpha-D-glucuronate = 16beta,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":51016,"RHEA_ID":59574,"compounds":"4-aminobutanoate + L-histidine => H2O + L-homocarnosine"}
{"X":51017,"RHEA_ID":50665,"DIRECTION":"LR","MASTER_ID":50664,"metacyc":"RXN-18234","compounds":"a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose => an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GlcNAc derivative + GDP + H(+)"}
{"X":51018,"RHEA_ID":49493,"DIRECTION":"LR","MASTER_ID":49492,"metacyc":"RXN-8954","compounds":"GDP-4-dehydro-alpha-D-rhamnose + L-glutamate => 2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + 2-oxoglutarate + H(+) + H2O"}
{"X":51019,"RHEA_ID":49494,"compounds":"2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + 2-oxoglutarate + H(+) + H2O => GDP-4-dehydro-alpha-D-rhamnose + L-glutamate"}
{"X":51020,"RHEA_ID":49495,"compounds":"GDP-4-dehydro-alpha-D-rhamnose + L-glutamate <=> 2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + 2-oxoglutarate + H(+) + H2O"}
{"X":51021,"RHEA_ID":59578,"compounds":"beta-alanine + N(pros)-methyl-L-histidine => anserine + H2O"}
{"X":51022,"RHEA_ID":49497,"DIRECTION":"LR","MASTER_ID":49496,"metacyc":"RXN-15217","compounds":"2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + H(+) => 2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane"}
{"X":51023,"RHEA_ID":49498,"compounds":"2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane => 2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + H(+)"}
{"X":51024,"RHEA_ID":49499,"compounds":"2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + H(+) <=> 2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane"}
{"X":51025,"RHEA_ID":59581,"compounds":"hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester => CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester"}
{"X":51026,"RHEA_ID":49501,"DIRECTION":"LR","MASTER_ID":49500,"metacyc":"RXN-15218","compounds":"2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane + H2O => GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+)"}
{"X":51027,"RHEA_ID":49502,"compounds":"GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+) => 2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane + H2O"}
{"X":51028,"RHEA_ID":49503,"compounds":"2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane + H2O <=> GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+)"}
{"X":51029,"RHEA_ID":59586,"compounds":"ADP + beta-alanyl-L-lysine + H(+) + phosphate => ATP + beta-alanine + L-lysine"}
{"X":51030,"RHEA_ID":49505,"DIRECTION":"LR","MASTER_ID":49504,"metacyc":"RXN-10830","compounds":"phosphinomethylmalate => phosphinomethylisomalate"}
{"X":51031,"RHEA_ID":49506,"compounds":"phosphinomethylisomalate => phosphinomethylmalate"}
{"X":51032,"RHEA_ID":59589,"compounds":"ATP + beta-alanine + L-ornithine => ADP + beta-alanyl-L-ornithine + H(+) + phosphate"}
{"X":51033,"RHEA_ID":50681,"DIRECTION":"LR","MASTER_ID":50680,"metacyc":"RXN-17879","compounds":"H2O + N-terminal L-glutaminyl-[protein] => N-terminal L-glutamyl-[protein] + NH4(+)"}
{"X":51034,"RHEA_ID":49509,"DIRECTION":"LR","MASTER_ID":49508,"metacyc":"RXN-17527","compounds":"phosphinomethylmalate => 2-(phosphinatomethylidene)butanedioate + H2O"}
{"X":51035,"RHEA_ID":49510,"compounds":"2-(phosphinatomethylidene)butanedioate + H2O => phosphinomethylmalate"}
{"X":51036,"RHEA_ID":52897,"DIRECTION":"LR","MASTER_ID":52896,"metacyc":"RXN-8060","compounds":"2 ATP + 2 H2O + 2 L-glutamine + Ni-sirohydrochlorin => 2 ADP + 2 H(+) + 2 L-glutamate + Ni-sirohydrochlorin a,c-diamide + 2 phosphate"}
{"X":51037,"RHEA_ID":52898,"compounds":"2 ADP + 2 H(+) + 2 L-glutamate + Ni-sirohydrochlorin a,c-diamide + 2 phosphate => 2 ATP + 2 H2O + 2 L-glutamine + Ni-sirohydrochlorin"}
{"X":51038,"RHEA_ID":49513,"DIRECTION":"LR","MASTER_ID":49512,"metacyc":"RXN-17528","compounds":"2-(phosphinatomethylidene)butanedioate + H2O => phosphinomethylisomalate"}
{"X":51039,"RHEA_ID":49514,"compounds":"phosphinomethylisomalate => 2-(phosphinatomethylidene)butanedioate + H2O"}
{"X":51040,"RHEA_ID":52901,"DIRECTION":"LR","MASTER_ID":52900,"metacyc":"RXN-8061","compounds":"3 AH2 + ATP + H2O + Ni-sirohydrochlorin a,c-diamide => 15,17(3)-seco-F430-17(3)-acid + 3 A + ADP + phosphate"}
{"X":51041,"RHEA_ID":59609,"compounds":"beta-alanyl-L-lysine + H2O => beta-alanine + L-lysine"}
{"X":51042,"RHEA_ID":49517,"compounds":"2-oxoglutarate + N(1)-methyladenosine in mRNA + O2 => adenosine in mRNA + CO2 + formaldehyde + succinate"}
{"X":51043,"RHEA_ID":49518,"compounds":"adenosine in mRNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + N(1)-methyladenosine in mRNA + O2"}
{"X":51044,"RHEA_ID":52905,"DIRECTION":"LR","MASTER_ID":52904,"metacyc":"RXN-8063","compounds":"15,17(3)-seco-F430-17(3)-acid + ATP => ADP + coenzyme F430 + phosphate"}
{"X":51045,"RHEA_ID":52906,"compounds":"ADP + coenzyme F430 + phosphate => 15,17(3)-seco-F430-17(3)-acid + ATP"}
{"X":51046,"RHEA_ID":49521,"compounds":"2-oxoglutarate + N(6)-methyladenosine in mRNA + O2 => adenosine in mRNA + CO2 + formaldehyde + succinate"}
{"X":51047,"RHEA_ID":49522,"compounds":"adenosine in mRNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + N(6)-methyladenosine in mRNA + O2"}
{"X":51048,"RHEA_ID":49523,"DIRECTION":"BI","MASTER_ID":49520,"metacyc":"RXN-17811","compounds":"2-oxoglutarate + N(6)-methyladenosine in mRNA + O2 <=> adenosine in mRNA + CO2 + formaldehyde + succinate"}
{"X":51049,"RHEA_ID":52910,"compounds":"3-dimethylallyl-4-hydroxymandelate + CO2 => 3-dimethylallyl-4-hydroxyphenylpyruvate + O2"}
{"X":51050,"RHEA_ID":49525,"compounds":"2-oxoglutarate + an N(6)-methyl-2'-deoxyadenosine in DNA + O2 => a 2'-deoxyadenosine in DNA + CO2 + formaldehyde + succinate"}
{"X":51051,"RHEA_ID":49526,"compounds":"a 2'-deoxyadenosine in DNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + an N(6)-methyl-2'-deoxyadenosine in DNA + O2"}
{"X":51052,"RHEA_ID":49527,"DIRECTION":"BI","MASTER_ID":49524,"metacyc":"RXN-17812","compounds":"2-oxoglutarate + an N(6)-methyl-2'-deoxyadenosine in DNA + O2 <=> a 2'-deoxyadenosine in DNA + CO2 + formaldehyde + succinate"}
{"X":51053,"RHEA_ID":52914,"compounds":"3-dimethylallyl-4-hydroxybenzoate + CO2 + H2O => 3-dimethylallyl-4-hydroxymandelate + O2"}
{"X":51054,"RHEA_ID":49529,"DIRECTION":"LR","MASTER_ID":49528,"metacyc":"RXN-17825","compounds":"(ethylene terephthalate)(n) + H2O => (ethylene terephthalate)(n-1) + 4-[(2-hydroxyethoxy)carbonyl]benzoate + H(+)"}
{"X":51055,"RHEA_ID":49530,"compounds":"(ethylene terephthalate)(n-1) + 4-[(2-hydroxyethoxy)carbonyl]benzoate + H(+) => (ethylene terephthalate)(n) + H2O"}
{"X":51056,"RHEA_ID":52918,"compounds":"16alpha,17alpha-estriol 17-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha,17alpha-estriol + UDP-alpha-D-glucuronate"}
{"X":51057,"RHEA_ID":49533,"DIRECTION":"LR","MASTER_ID":49532,"metacyc":"RXN-17826","compounds":"4-[(2-hydroxyethoxy)carbonyl]benzoate + H2O => ethylene glycol + H(+) + terephthalate"}
{"X":51058,"RHEA_ID":49534,"compounds":"ethylene glycol + H(+) + terephthalate => 4-[(2-hydroxyethoxy)carbonyl]benzoate + H2O"}
{"X":51059,"RHEA_ID":49535,"compounds":"4-[(2-hydroxyethoxy)carbonyl]benzoate + H2O <=> ethylene glycol + H(+) + terephthalate"}
{"X":51060,"RHEA_ID":52922,"compounds":"16alpha,17alpha-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha,17alpha-estriol + UDP-alpha-D-glucuronate"}
{"X":51061,"RHEA_ID":59631,"compounds":"H2O + N(2)-(4-aminobutanoyl)-L-arginine <=> 4-aminobutanoate + L-arginine"}
{"X":51062,"RHEA_ID":52924,"compounds":"16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":51063,"RHEA_ID":59633,"compounds":"D-xylobiose + O2 => D-xylobiono-1,5-lactone + H2O2"}
{"X":51064,"RHEA_ID":49540,"compounds":"(2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate = (4S,5R)-4,5,6-trihydroxy-2-iminohexanoate"}
{"X":51065,"RHEA_ID":59635,"compounds":"D-xylobiose + O2 <=> D-xylobiono-1,5-lactone + H2O2"}
{"X":51066,"RHEA_ID":49542,"compounds":"(4S,5R)-4,5,6-trihydroxy-2-iminohexanoate => (2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate"}
{"X":51067,"RHEA_ID":52929,"compounds":"cyclic di-3',5'-guanylate + 2 H2O => 2 GMP + 2 H(+)"}
{"X":51068,"RHEA_ID":52930,"compounds":"2 GMP + 2 H(+) => cyclic di-3',5'-guanylate + 2 H2O"}
{"X":51069,"RHEA_ID":59639,"compounds":"D-xylotriose + O2 <=> D-xylotriono-1,5-lactone + H2O2"}
{"X":51070,"RHEA_ID":59640,"compounds":"D-xylotetraose + O2 = D-xylotetraono-1,5-lactone + H2O2"}
{"X":51071,"RHEA_ID":59641,"compounds":"D-xylotetraose + O2 => D-xylotetraono-1,5-lactone + H2O2"}
{"X":51072,"RHEA_ID":52938,"compounds":"(3S)-hydroxy-3-methylglutaryl-[ACP] + H(+) + holo-[ACP] => 3-oxobutanoyl-[ACP] + acetyl-[ACP] + H2O"}
{"X":51073,"RHEA_ID":59643,"compounds":"D-xylotetraose + O2 <=> D-xylotetraono-1,5-lactone + H2O2"}
{"X":51074,"RHEA_ID":59644,"compounds":"D-xylobiono-1,5-lactone + H2O = D-xylobionate + H(+)"}
{"X":51075,"RHEA_ID":52941,"compounds":"chenodeoxycholate + UDP-alpha-D-glucuronate => chenodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP"}
{"X":51076,"RHEA_ID":52942,"compounds":"chenodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP => chenodeoxycholate + UDP-alpha-D-glucuronate"}
{"X":51077,"RHEA_ID":59647,"compounds":"D-xylobiono-1,5-lactone + H2O <=> D-xylobionate + H(+)"}
{"X":51078,"RHEA_ID":52944,"compounds":"cholate + UDP-alpha-D-glucuronate = choloyl-24-O-(beta-D-glucuronate) + UDP"}
{"X":51079,"RHEA_ID":52945,"compounds":"cholate + UDP-alpha-D-glucuronate => choloyl-24-O-(beta-D-glucuronate) + UDP"}
{"X":51080,"RHEA_ID":52946,"compounds":"choloyl-24-O-(beta-D-glucuronate) + UDP => cholate + UDP-alpha-D-glucuronate"}
{"X":51081,"RHEA_ID":59651,"compounds":"D-xylotriono-1,5-lactone + H2O <=> D-xylotrionate + H(+)"}
{"X":51082,"RHEA_ID":49558,"compounds":"H(+) + L-cysteinyl-[protein] + lactate => H2O + S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein]"}
{"X":51083,"RHEA_ID":52949,"compounds":"deoxycholate + UDP-alpha-D-glucuronate => deoxycholoyl-24-O-(beta-D-glucuronate) + UDP"}
{"X":51084,"RHEA_ID":52950,"compounds":"deoxycholoyl-24-O-(beta-D-glucuronate) + UDP => deoxycholate + UDP-alpha-D-glucuronate"}
{"X":51085,"RHEA_ID":59655,"compounds":"D-xylotetraono-1,5-lactone + H2O <=> D-xylotetraonate + H(+)"}
{"X":51086,"RHEA_ID":59656,"compounds":"D-cellotriose + O2 = D-cellotriono-1,5-lactone + H2O2"}
{"X":51087,"RHEA_ID":52953,"compounds":"lithocholate + UDP-alpha-D-glucuronate => lithocholoyl-24-O-(beta-D-glucuronate) + UDP"}
{"X":51088,"RHEA_ID":52954,"compounds":"lithocholoyl-24-O-(beta-D-glucuronate) + UDP => lithocholate + UDP-alpha-D-glucuronate"}
{"X":51089,"RHEA_ID":59659,"compounds":"D-cellotriose + O2 <=> D-cellotriono-1,5-lactone + H2O2"}
{"X":51090,"RHEA_ID":59660,"compounds":"D-cellotetraose + O2 = D-cellotetraono-1,5-lactone + H2O2"}
{"X":51091,"RHEA_ID":52957,"compounds":"hyodeoxycholate + UDP-alpha-D-glucuronate => hyodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP"}
{"X":51092,"RHEA_ID":52958,"compounds":"hyodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP => hyodeoxycholate + UDP-alpha-D-glucuronate"}
{"X":51093,"RHEA_ID":49569,"compounds":"2-glutathionyl-2-methylbut-3-en-1-ol => (3R)-3,4-epoxy-3-methylbut-1-ene + glutathione"}
{"X":51094,"RHEA_ID":49570,"DIRECTION":"RL","MASTER_ID":49568,"metacyc":"RXN-17592","compounds":"(3R)-3,4-epoxy-3-methylbut-1-ene + glutathione => 2-glutathionyl-2-methylbut-3-en-1-ol"}
{"X":51095,"RHEA_ID":59665,"compounds":"D-cellopentaose + O2 => D-cellopentaono-1,5-lactone + H2O2"}
{"X":51096,"RHEA_ID":52962,"compounds":"hyocholoyl-24-O-(beta-D-glucuronate) + UDP => hyocholate + UDP-alpha-D-glucuronate"}
{"X":51097,"RHEA_ID":59667,"compounds":"D-cellopentaose + O2 <=> D-cellopentaono-1,5-lactone + H2O2"}
{"X":51098,"RHEA_ID":49574,"DIRECTION":"RL","MASTER_ID":49572,"metacyc":"RXN-17518","compounds":"coproporphyrin III + Fe(2+) => Fe-coproporphyrin III + 2 H(+)"}
{"X":51099,"RHEA_ID":52965,"compounds":"hyodeoxycholate + UDP-alpha-D-glucuronate => H(+) + hyodeoxycholate 6-O-(beta-D-glucuronate) + UDP"}
{"X":51100,"RHEA_ID":52966,"compounds":"H(+) + hyodeoxycholate 6-O-(beta-D-glucuronate) + UDP => hyodeoxycholate + UDP-alpha-D-glucuronate"}
{"X":51101,"RHEA_ID":49577,"DIRECTION":"LR","MASTER_ID":49576,"ecocyc":"RXN-8340","metacyc":"RXN-8340","compounds":"AH2 + GTP + S-adenosyl-L-methionine => (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine"}
{"X":51102,"RHEA_ID":49578,"compounds":"(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine => AH2 + GTP + S-adenosyl-L-methionine"}
{"X":51103,"RHEA_ID":52969,"compounds":"hyocholate + UDP-alpha-D-glucuronate => H(+) + hyocholate 6-O-(beta-D-glucuronate) + UDP"}
{"X":51104,"RHEA_ID":49580,"DIRECTION":"UN","MASTER_ID":49580,"ec":"4.6.1.17","compounds":"(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate"}
{"X":51105,"RHEA_ID":59675,"compounds":"D-maltotriose + O2 <=> D-maltotriono-1,5-lactone + H2O2"}
{"X":51106,"RHEA_ID":49582,"compounds":"cyclic pyranopterin phosphate + diphosphate => (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate"}
{"X":51107,"RHEA_ID":59677,"compounds":"D-maltotetraose + O2 => D-maltotetraono-1,5-lactone + H2O2"}
{"X":51108,"RHEA_ID":52974,"compounds":"a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin] => a C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin]"}
{"X":51109,"RHEA_ID":59679,"compounds":"D-maltotetraose + O2 <=> D-maltotetraono-1,5-lactone + H2O2"}
{"X":51110,"RHEA_ID":49586,"compounds":"L-erythrulose 1-phosphate => D-erythrulose 1-phosphate"}
{"X":51111,"RHEA_ID":59680,"compounds":"D-maltopentaose + O2 = D-maltopentaono-1,5-lactone + H2O2"}
{"X":51112,"RHEA_ID":52978,"compounds":"a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin] => a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin]"}
{"X":51113,"RHEA_ID":49589,"compounds":"L-erythrulose 1-phosphate => D-erythrulose 4-phosphate"}
{"X":51114,"RHEA_ID":49590,"compounds":"D-erythrulose 4-phosphate => L-erythrulose 1-phosphate"}
{"X":51115,"RHEA_ID":59685,"compounds":"D-maltohexaose + O2 => D-maltohexaono-1,5-lactone + H2O2"}
{"X":51116,"RHEA_ID":52982,"compounds":"7-oxoheptanoyl-[ACP] + a fatty aldehyde + H(+) + 2 H2O + oxidized [flavodoxin] => a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin]"}
{"X":51117,"RHEA_ID":59687,"compounds":"D-maltohexaose + O2 <=> D-maltohexaono-1,5-lactone + H2O2"}
{"X":51118,"RHEA_ID":52984,"compounds":"7-oxoheptanoyl-[ACP] + H2O + oxidized [flavodoxin] = 6-carboxyhexanoyl-[ACP] + reduced [flavodoxin]"}
{"X":51119,"RHEA_ID":59689,"compounds":"D-maltoheptaose + O2 => D-maltoheptaono-1,5-lactone + H2O2"}
{"X":51120,"RHEA_ID":52986,"compounds":"6-carboxyhexanoyl-[ACP] + reduced [flavodoxin] => 7-oxoheptanoyl-[ACP] + H2O + oxidized [flavodoxin]"}
{"X":51121,"RHEA_ID":49597,"compounds":"an N-acylsphing-4-enine + UDP-alpha-D-galactose => H(+) + N-acyl-D-galactosylsphing-4-enine + UDP"}
{"X":51122,"RHEA_ID":52988,"compounds":"[deoxyhypusine synthase]-L-lysine + dehydrospermidine = [deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + propane-1,3-diamine"}
{"X":51123,"RHEA_ID":49599,"compounds":"an N-acylsphing-4-enine + UDP-alpha-D-galactose <=> H(+) + N-acyl-D-galactosylsphing-4-enine + UDP"}
{"X":51124,"RHEA_ID":56325,"DIRECTION":"LR","MASTER_ID":56324,"ecocyc":"RXN-17823","metacyc":"RXN-17823","compounds":"a methylphosphotriester deoxyribonucleoside in DNA + L-cysteinyl-[protein] => a deoxyribonucleotide in DNA + H(+) + S-methyl-L-cysteinyl-[protein]"}
{"X":51125,"RHEA_ID":59695,"compounds":"D-cellotriono-1,5-lactone + H2O <=> D-cellotrionate + H(+)"}
{"X":51126,"RHEA_ID":49602,"compounds":"AMP + diphosphate + octanedioyl-CoA => ATP + CoA + octanedioate"}
{"X":51127,"RHEA_ID":49603,"compounds":"ATP + CoA + octanedioate <=> AMP + diphosphate + octanedioyl-CoA"}
{"X":51128,"RHEA_ID":52994,"compounds":"[deoxyhypusine synthase]-L-lysine + [eIF5A protein]-N-(4-aminobutylidene)-L-lysine => [deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + [eIF5A protein]-L-lysine"}
{"X":51129,"RHEA_ID":59699,"compounds":"D-cellotetraono-1,5-lactone + H2O <=> D-cellotetraonate + H(+)"}
{"X":51130,"RHEA_ID":49606,"compounds":"2-glutathionyl-2-methylbut-3-enal + H(+) + NADH => 2-glutathionyl-2-methylbut-3-en-1-ol + NAD(+)"}
{"X":51131,"RHEA_ID":49607,"compounds":"2-glutathionyl-2-methylbut-3-en-1-ol + NAD(+) <=> 2-glutathionyl-2-methylbut-3-enal + H(+) + NADH"}
{"X":51132,"RHEA_ID":49608,"compounds":"2-glutathionyl-2-methylbut-3-enal + H2O + NAD(+) = 2-glutathionyl-2-methylbut-3-enoate + 2 H(+) + NADH"}
{"X":51133,"RHEA_ID":49609,"DIRECTION":"LR","MASTER_ID":49608,"metacyc":"RXN-17594","compounds":"2-glutathionyl-2-methylbut-3-enal + H2O + NAD(+) => 2-glutathionyl-2-methylbut-3-enoate + 2 H(+) + NADH"}
{"X":51134,"RHEA_ID":53000,"compounds":"17beta-hydroxy-5alpha-androstan-3-one + UDP-alpha-D-glucuronate = 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":51135,"RHEA_ID":49611,"compounds":"2-glutathionyl-2-methylbut-3-enal + H2O + NAD(+) <=> 2-glutathionyl-2-methylbut-3-enoate + 2 H(+) + NADH"}
{"X":51136,"RHEA_ID":49612,"DIRECTION":"UN","MASTER_ID":49612,"ec":"1.1.1.399","compounds":"(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH"}
{"X":51137,"RHEA_ID":49613,"compounds":"(R)-2-hydroxyglutarate + NAD(+) => 2-oxoglutarate + H(+) + NADH"}
{"X":51138,"RHEA_ID":59708,"compounds":"D-maltotriono-1,5-lactone + H2O = D-maltotrionate + H(+)"}
{"X":51139,"RHEA_ID":59709,"compounds":"D-maltotriono-1,5-lactone + H2O => D-maltotrionate + H(+)"}
{"X":51140,"RHEA_ID":53006,"compounds":"2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP => 2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate"}
{"X":51141,"RHEA_ID":49617,"DIRECTION":"LR","MASTER_ID":49616,"metacyc":"RXN-17603","compounds":"2-hydroxy-2-methylpropanal + H2O + NAD(+) => 2-hydroxy-2-methylpropanoate + 2 H(+) + NADH"}
{"X":51142,"RHEA_ID":53008,"DIRECTION":"UN","MASTER_ID":53008,"ec":"2.5.1.87","compounds":"(2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate = di-trans,poly-cis-polyprenyl diphosphate + n diphosphate"}
{"X":51143,"RHEA_ID":59713,"compounds":"D-maltotetraono-1,5-lactone + H2O => D-maltotetraonate + H(+)"}
{"X":51144,"RHEA_ID":49620,"DIRECTION":"UN","MASTER_ID":49620,"ec":"1.1.1.402","compounds":"D-erythritol 1-phosphate + NADP(+) = D-erythrulose 1-phosphate + H(+) + NADPH"}
{"X":51145,"RHEA_ID":49621,"DIRECTION":"LR","MASTER_ID":49620,"metacyc":"RXN-17768","compounds":"D-erythritol 1-phosphate + NADP(+) => D-erythrulose 1-phosphate + H(+) + NADPH"}
{"X":51146,"RHEA_ID":59716,"compounds":"D-maltopentaono-1,5-lactone + H2O = D-maltopentaonate + H(+)"}
{"X":51147,"RHEA_ID":59717,"compounds":"D-maltopentaono-1,5-lactone + H2O => D-maltopentaonate + H(+)"}
{"X":51148,"RHEA_ID":53014,"compounds":"chloride + chlorohydroquinone + glutathione disulfide + H(+) => 2,5-dichlorohydroquinone + 2 glutathione"}
{"X":51149,"RHEA_ID":49625,"DIRECTION":"LR","MASTER_ID":49624,"metacyc":"RXN-17770","compounds":"ATP + erythritol => ADP + D-erythritol 1-phosphate + H(+)"}
{"X":51150,"RHEA_ID":59720,"compounds":"D-maltohexaono-1,5-lactone + H2O = D-maltohexaonate + H(+)"}
{"X":51151,"RHEA_ID":49627,"compounds":"ATP + erythritol <=> ADP + D-erythritol 1-phosphate + H(+)"}
{"X":51152,"RHEA_ID":49628,"compounds":"acetyl-CoA + 3 malonyl-CoA + 2 S-adenosyl-L-methionine = 3,5-dimethylorsellinate + 3 CO2 + 4 CoA + 2 S-adenosyl-L-homocysteine"}
{"X":51153,"RHEA_ID":49629,"DIRECTION":"LR","MASTER_ID":49628,"metacyc":"RXN-16072","compounds":"acetyl-CoA + 3 malonyl-CoA + 2 S-adenosyl-L-methionine => 3,5-dimethylorsellinate + 3 CO2 + 4 CoA + 2 S-adenosyl-L-homocysteine"}
{"X":51154,"RHEA_ID":53020,"compounds":"a plastoquinone + an L-alpha-amino acid + H2O = a 2-oxocarboxylate + a plastoquinol + NH4(+)"}
{"X":51155,"RHEA_ID":49631,"compounds":"acetyl-CoA + 3 malonyl-CoA + 2 S-adenosyl-L-methionine <=> 3,5-dimethylorsellinate + 3 CO2 + 4 CoA + 2 S-adenosyl-L-homocysteine"}
{"X":51156,"RHEA_ID":49632,"compounds":"(2E,6E)-farnesyl diphosphate + 3,5-dimethylorsellinate = (3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + diphosphate + H(+)"}
{"X":51157,"RHEA_ID":53023,"compounds":"a plastoquinone + an L-alpha-amino acid + H2O <=> a 2-oxocarboxylate + a plastoquinol + NH4(+)"}
{"X":51158,"RHEA_ID":59727,"compounds":"D-maltoheptaono-1,5-lactone + H2O <=> D-maltoheptaonate + H(+)"}
{"X":51159,"RHEA_ID":49635,"compounds":"(2E,6E)-farnesyl diphosphate + 3,5-dimethylorsellinate <=> (3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + diphosphate + H(+)"}
{"X":51160,"RHEA_ID":49636,"DIRECTION":"UN","MASTER_ID":49636,"ec":"1.2.3.15","compounds":"H2O + methylglyoxal + O2 = H(+) + H2O2 + pyruvate"}
{"X":51161,"RHEA_ID":49637,"DIRECTION":"LR","MASTER_ID":49636,"metacyc":"RXN-17510","compounds":"H2O + methylglyoxal + O2 => H(+) + H2O2 + pyruvate"}
{"X":51162,"RHEA_ID":53028,"compounds":"lithocholate + UDP-alpha-D-glucuronate = H(+) + lithocholoyl-3-O-(beta-D-glucuronate) + UDP"}
{"X":51163,"RHEA_ID":49652,"DIRECTION":"UN","MASTER_ID":49652,"ec":"1.14.13.224","compounds":"H(+) + NADH + O2 + protoviolaceinate = H2O + NAD(+) + violaceinate"}
{"X":51164,"RHEA_ID":49653,"DIRECTION":"LR","MASTER_ID":49652,"metacyc":"RXN-13342","compounds":"H(+) + NADH + O2 + protoviolaceinate => H2O + NAD(+) + violaceinate"}
{"X":51165,"RHEA_ID":49654,"compounds":"H2O + NAD(+) + violaceinate => H(+) + NADH + O2 + protoviolaceinate"}
{"X":51166,"RHEA_ID":59737,"compounds":"L-cysteinyl-[protein] + tetradecanoyl-CoA => CoA + S-tetradecanoyl-L-cysteinyl-[protein]"}
{"X":51167,"RHEA_ID":49668,"DIRECTION":"UN","MASTER_ID":49668,"ec":"1.14.13.224","compounds":"H(+) + NADH + O2 + protodeoxyviolaceinate = deoxyviolaceinate + H2O + NAD(+)"}
{"X":51168,"RHEA_ID":49669,"DIRECTION":"LR","MASTER_ID":49668,"metacyc":"RXN-13344","compounds":"H(+) + NADH + O2 + protodeoxyviolaceinate => deoxyviolaceinate + H2O + NAD(+)"}
{"X":51169,"RHEA_ID":59740,"compounds":"L-cysteinyl-[protein] + octadecanoyl-CoA = CoA + S-octadecanoyl-L-cysteinyl-[protein]"}
{"X":51170,"RHEA_ID":59741,"compounds":"L-cysteinyl-[protein] + octadecanoyl-CoA => CoA + S-octadecanoyl-L-cysteinyl-[protein]"}
{"X":51171,"RHEA_ID":49676,"DIRECTION":"UN","MASTER_ID":49676,"ec":"1.14.13.225","compounds":"H(+) + L-methionyl(47)-[F-actin] + NADPH + O2 = H2O + L-methionyl(47)-(R)-S-oxide-[F-actin] + NADP(+)"}
{"X":51172,"RHEA_ID":49677,"compounds":"H(+) + L-methionyl(47)-[F-actin] + NADPH + O2 => H2O + L-methionyl(47)-(R)-S-oxide-[F-actin] + NADP(+)"}
{"X":51173,"RHEA_ID":59744,"compounds":"(9Z)-octadecenoyl-CoA + L-cysteinyl-[protein] = CoA + S-(9Z-octadecenoyl)-L-cysteinyl-[protein]"}
{"X":51174,"RHEA_ID":49679,"DIRECTION":"BI","MASTER_ID":49676,"metacyc":"RXN-17513","compounds":"H(+) + L-methionyl(47)-[F-actin] + NADPH + O2 <=> H2O + L-methionyl(47)-(R)-S-oxide-[F-actin] + NADP(+)"}
{"X":51175,"RHEA_ID":49684,"DIRECTION":"UN","MASTER_ID":49684,"ec":"1.14.13.220","compounds":"H(+) + NADH + O2 + resorcinol = benzene-1,2,4-triol + H2O + NAD(+)"}
{"X":51176,"RHEA_ID":54136,"compounds":"cytidine(48) in tRNA precursor + S-adenosyl-L-methionine = 5-methylcytidine(48) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine"}
{"X":51177,"RHEA_ID":59748,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + L-cysteinyl-[protein] = CoA + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-cysteinyl-[protein]"}
{"X":51178,"RHEA_ID":59749,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + L-cysteinyl-[protein] => CoA + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-cysteinyl-[protein]"}
{"X":51179,"RHEA_ID":53046,"compounds":"a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine"}
{"X":51180,"RHEA_ID":49709,"DIRECTION":"LR","MASTER_ID":49708,"metacyc":"RXN-17837","compounds":"nocardicin G + S-adenosyl-L-methionine => H(+) + isonocardicin C + S-methyl-5'-thioadenosine"}
{"X":51181,"RHEA_ID":59752,"compounds":"L-lysyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N(6)-tetradecanoyl-L-lysyl-[protein]"}
{"X":51182,"RHEA_ID":59753,"compounds":"L-lysyl-[protein] + tetradecanoyl-CoA => CoA + H(+) + N(6)-tetradecanoyl-L-lysyl-[protein]"}
{"X":51183,"RHEA_ID":49716,"DIRECTION":"UN","MASTER_ID":49716,"ec":"1.14.13.223","compounds":"3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] + H(+) + NADH + O2 = 3,5-dihydroxy-4-methylanthranilyl-[aryl-carrier protein] + H2O + NAD(+)"}
{"X":51184,"RHEA_ID":49717,"DIRECTION":"LR","MASTER_ID":49716,"metacyc":"RXN-17497","compounds":"3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] + H(+) + NADH + O2 => 3,5-dihydroxy-4-methylanthranilyl-[aryl-carrier protein] + H2O + NAD(+)"}
{"X":51185,"RHEA_ID":59755,"compounds":"L-lysyl-[protein] + tetradecanoyl-CoA <=> CoA + H(+) + N(6)-tetradecanoyl-L-lysyl-[protein]"}
{"X":51186,"RHEA_ID":49720,"DIRECTION":"UN","MASTER_ID":49720,"ec":"1.14.13.224","compounds":"2 H(+) + NADH + 2 O2 + protoviolaceinate = CO2 + 2 H2O + NAD(+) + violacein"}
{"X":51187,"RHEA_ID":49721,"compounds":"2 H(+) + NADH + 2 O2 + protoviolaceinate => CO2 + 2 H2O + NAD(+) + violacein"}
{"X":51188,"RHEA_ID":59767,"compounds":"L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + octadecanoyl-CoA <=> CoA + H(+) + N(6)-octadecanoyl-L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein]"}
{"X":51189,"RHEA_ID":49723,"compounds":"2 H(+) + NADH + 2 O2 + protoviolaceinate <=> CO2 + 2 H2O + NAD(+) + violacein"}
{"X":51190,"RHEA_ID":49728,"DIRECTION":"UN","MASTER_ID":49728,"ec":"1.14.13.224","compounds":"2 H(+) + NADPH + 2 O2 + protoviolaceinate = CO2 + 2 H2O + NADP(+) + violacein"}
{"X":51191,"RHEA_ID":49729,"compounds":"2 H(+) + NADPH + 2 O2 + protoviolaceinate => CO2 + 2 H2O + NADP(+) + violacein"}
{"X":51192,"RHEA_ID":49731,"compounds":"2 H(+) + NADPH + 2 O2 + protoviolaceinate <=> CO2 + 2 H2O + NADP(+) + violacein"}
{"X":51193,"RHEA_ID":49732,"DIRECTION":"UN","MASTER_ID":49732,"ec":"1.14.13.224","compounds":"H(+) + O2 + violaceinate = CO2 + H2O + violacein"}
{"X":51194,"RHEA_ID":49733,"DIRECTION":"LR","MASTER_ID":49732,"metacyc":"RXN-13343","compounds":"H(+) + O2 + violaceinate => CO2 + H2O + violacein"}
{"X":51195,"RHEA_ID":49734,"compounds":"CO2 + H2O + violacein => H(+) + O2 + violaceinate"}
{"X":51196,"RHEA_ID":59785,"compounds":"H2O + NADP(+) + pseudopaline => (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADPH"}
{"X":51197,"RHEA_ID":59786,"DIRECTION":"RL","MASTER_ID":59784,"metacyc":"RXN-19825","compounds":"(2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADPH => H2O + NADP(+) + pseudopaline"}
{"X":51198,"RHEA_ID":49737,"compounds":"2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate => CO2 + deoxyviolacein + 2 H2O + NAD(+)"}
{"X":51199,"RHEA_ID":49739,"compounds":"2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate <=> CO2 + deoxyviolacein + 2 H2O + NAD(+)"}
{"X":51200,"RHEA_ID":59790,"compounds":"(2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADH => H2O + NAD(+) + pseudopaline"}
{"X":51201,"RHEA_ID":49741,"compounds":"2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate => CO2 + deoxyviolacein + 2 H2O + NADP(+)"}
{"X":51202,"RHEA_ID":49742,"compounds":"CO2 + deoxyviolacein + 2 H2O + NADP(+) => 2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate"}
{"X":51203,"RHEA_ID":49743,"compounds":"2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate <=> CO2 + deoxyviolacein + 2 H2O + NADP(+)"}
{"X":51204,"RHEA_ID":59794,"DIRECTION":"RL","MASTER_ID":59792,"metacyc":"RXN-19826","compounds":"(2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate => H2O + NADP(+) + yersinopine"}
{"X":51205,"RHEA_ID":49745,"DIRECTION":"LR","MASTER_ID":49744,"metacyc":"RXN-13345","compounds":"deoxyviolaceinate + H(+) + O2 => CO2 + deoxyviolacein + H2O"}
{"X":51206,"RHEA_ID":56411,"compounds":"(9Z,12Z,15Z)-octadecatrienoyl-CoA + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1-(9Z-octadecaenoyl)-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":51207,"RHEA_ID":59797,"compounds":"dodecanoyl-CoA + L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein] => CoA + H(+) + N(6)-dodecanoyl-L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein]"}
{"X":51208,"RHEA_ID":59798,"compounds":"CoA + H(+) + N(6)-dodecanoyl-L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein] => dodecanoyl-CoA + L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein]"}
{"X":51209,"RHEA_ID":49749,"compounds":"2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate => CO2 + 2 H2O + NADP(+) + proviolacein"}
{"X":51210,"RHEA_ID":49750,"compounds":"CO2 + 2 H2O + NADP(+) + proviolacein => 2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate"}
{"X":51211,"RHEA_ID":49751,"compounds":"2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate <=> CO2 + 2 H2O + NADP(+) + proviolacein"}
{"X":51212,"RHEA_ID":59802,"compounds":"CoA + H(+) + N(6)-decanoyl-L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein] => decanoyl-CoA + L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein]"}
{"X":51213,"RHEA_ID":49753,"compounds":"2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate => CO2 + 2 H2O + NAD(+) + proviolacein"}
{"X":51214,"RHEA_ID":49754,"compounds":"CO2 + 2 H2O + NAD(+) + proviolacein => 2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate"}
{"X":51215,"RHEA_ID":49755,"compounds":"2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate <=> CO2 + 2 H2O + NAD(+) + proviolacein"}
{"X":51216,"RHEA_ID":49756,"DIRECTION":"UN","MASTER_ID":49756,"ec":"1.14.13.217","compounds":"H(+) + O2 + protoviolaceinate = CO2 + H2O + proviolacein"}
{"X":51217,"RHEA_ID":49757,"DIRECTION":"LR","MASTER_ID":49756,"metacyc":"RXN-13347","compounds":"H(+) + O2 + protoviolaceinate => CO2 + H2O + proviolacein"}
{"X":51218,"RHEA_ID":49758,"compounds":"CO2 + H2O + proviolacein => H(+) + O2 + protoviolaceinate"}
{"X":51219,"RHEA_ID":49759,"compounds":"H(+) + O2 + protoviolaceinate <=> CO2 + H2O + proviolacein"}
{"X":51220,"RHEA_ID":59810,"compounds":"D-tyrosine => L-tyrosine"}
{"X":51221,"RHEA_ID":49761,"DIRECTION":"LR","MASTER_ID":49760,"metacyc":"RXN-17507","compounds":"EDTA + FMNH2 + O2 => ethylenediaminetriacetate + FMN + glyoxylate + 2 H(+) + H2O"}
{"X":51222,"RHEA_ID":49762,"compounds":"ethylenediaminetriacetate + FMN + glyoxylate + 2 H(+) + H2O => EDTA + FMNH2 + O2"}
{"X":51223,"RHEA_ID":59813,"compounds":"hexadecanoyl-CoA + N-terminal glycyl-[protein] => CoA + H(+) + N-terminal N(6)-hexadecanoylglycyl-[protein]"}
{"X":51224,"RHEA_ID":49764,"compounds":"ethylenediaminetriacetate + FMNH2 + O2 = ethylenediaminediacetate + FMN + glyoxylate + H(+) + H2O"}
{"X":51225,"RHEA_ID":49765,"DIRECTION":"LR","MASTER_ID":49764,"metacyc":"RXN-17508","compounds":"ethylenediaminetriacetate + FMNH2 + O2 => ethylenediaminediacetate + FMN + glyoxylate + H(+) + H2O"}
{"X":51226,"RHEA_ID":59820,"compounds":"2 ATP = adenosine 3'-diphosphate,5'-triphosphate + AMP"}
{"X":51227,"RHEA_ID":59821,"compounds":"2 ATP => adenosine 3'-diphosphate,5'-triphosphate + AMP"}
{"X":51228,"RHEA_ID":59822,"compounds":"adenosine 3'-diphosphate,5'-triphosphate + AMP => 2 ATP"}
{"X":51229,"RHEA_ID":49773,"compounds":"glycine + hexacosanoyl-CoA => CoA + H(+) + N-hexacosanoylglycine"}
{"X":51230,"RHEA_ID":59828,"compounds":"H2O + S-inosyl-L-homocysteine = inosine + L-homocysteine"}
{"X":51231,"RHEA_ID":49775,"compounds":"glycine + hexacosanoyl-CoA <=> CoA + H(+) + N-hexacosanoylglycine"}
{"X":51232,"RHEA_ID":59830,"compounds":"inosine + L-homocysteine => H2O + S-inosyl-L-homocysteine"}
{"X":51233,"RHEA_ID":49781,"compounds":"docosanoyl-CoA + glycine => CoA + H(+) + N-docosanoylglycine"}
{"X":51234,"RHEA_ID":49782,"compounds":"CoA + H(+) + N-docosanoylglycine => docosanoyl-CoA + glycine"}
{"X":51235,"RHEA_ID":49783,"compounds":"docosanoyl-CoA + glycine <=> CoA + H(+) + N-docosanoylglycine"}
{"X":51236,"RHEA_ID":59834,"compounds":"ADP + H(+) + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein] => ATP + N(6)-(D-fructosyl)-L-lysyl-[protein]"}
{"X":51237,"RHEA_ID":49785,"compounds":"chenodeoxycholoyl-CoA + taurine => CoA + H(+) + taurochenodeoxycholate"}
{"X":51238,"RHEA_ID":49786,"compounds":"CoA + H(+) + taurochenodeoxycholate => chenodeoxycholoyl-CoA + taurine"}
{"X":51239,"RHEA_ID":49787,"compounds":"chenodeoxycholoyl-CoA + taurine <=> CoA + H(+) + taurochenodeoxycholate"}
{"X":51240,"RHEA_ID":59838,"compounds":"3-deoxyglucosone + L-lysyl-[protein] + phosphate => H2O + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein]"}
{"X":51241,"RHEA_ID":49789,"compounds":"chenodeoxycholoyl-CoA + glycine => CoA + glycochenodeoxycholate + H(+)"}
{"X":51242,"RHEA_ID":49790,"compounds":"CoA + glycochenodeoxycholate + H(+) => chenodeoxycholoyl-CoA + glycine"}
{"X":51243,"RHEA_ID":49791,"compounds":"chenodeoxycholoyl-CoA + glycine <=> CoA + glycochenodeoxycholate + H(+)"}
{"X":51244,"RHEA_ID":53114,"compounds":"5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + NADPH => 3alpha-hydroxy-5alpha-androstane 17-O-(beta-D-glucuronate) + NADP(+)"}
{"X":51245,"RHEA_ID":49793,"compounds":"eicosanoyl-CoA + glycine => CoA + H(+) + N-eicosanoylglycinate"}
{"X":51246,"RHEA_ID":49794,"compounds":"CoA + H(+) + N-eicosanoylglycinate => eicosanoyl-CoA + glycine"}
{"X":51247,"RHEA_ID":49795,"compounds":"eicosanoyl-CoA + glycine <=> CoA + H(+) + N-eicosanoylglycinate"}
{"X":51248,"RHEA_ID":59846,"compounds":"(R)-isodihydrodehydrodiconiferyl alcohol + NADP(+) => (+)-dehydrodiconiferyl alcohol + H(+) + NADPH"}
{"X":51249,"RHEA_ID":49797,"compounds":"an N-acylglycine + H2O => a fatty acid + glycine"}
{"X":51250,"RHEA_ID":49798,"compounds":"a fatty acid + glycine => an N-acylglycine + H2O"}
{"X":51251,"RHEA_ID":49799,"compounds":"an N-acylglycine + H2O <=> a fatty acid + glycine"}
{"X":51252,"RHEA_ID":59850,"compounds":"(S)-tetrahydrodehydrodiconiferyl alcohol + NADP(+) => (2R,3S)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH"}
{"X":51253,"RHEA_ID":49805,"compounds":"2-methylpropan-1-amine + FMNH2 + O2 => FMN + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine"}
{"X":51254,"RHEA_ID":49806,"compounds":"FMN + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine => 2-methylpropan-1-amine + FMNH2 + O2"}
{"X":51255,"RHEA_ID":59853,"compounds":"(2S,3R)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH => (R)-tetrahydrodehydrodiconiferyl alcohol + NADP(+)"}
{"X":51256,"RHEA_ID":53126,"compounds":"delta-carotene => all-trans-lycopene"}
{"X":51257,"RHEA_ID":49809,"DIRECTION":"LR","MASTER_ID":49808,"metacyc":"RXN-17641","compounds":"a quinone + butan-1-ol => a quinol + butanal"}
{"X":51258,"RHEA_ID":49810,"compounds":"a quinol + butanal => a quinone + butan-1-ol"}
{"X":51259,"RHEA_ID":49811,"compounds":"a quinone + butan-1-ol <=> a quinol + butanal"}
{"X":51260,"RHEA_ID":59858,"compounds":"[methyl-Co(III) tetramethylammonium-specific corrinoid protein] + trimethylamine => [Co(I) tetramethylammonium-specific corrinoid protein] + H(+) + tetramethylammonium"}
{"X":51261,"RHEA_ID":49817,"compounds":"3 [Fe(III)cytochrome c] + H2O + hydrazine => 3 [Fe(II)cytochrome c] + 2 H(+) + NH4(+) + nitric oxide"}
{"X":51262,"RHEA_ID":49818,"DIRECTION":"RL","MASTER_ID":49816,"metacyc":"RXN-11175","compounds":"3 [Fe(II)cytochrome c] + 2 H(+) + NH4(+) + nitric oxide => 3 [Fe(III)cytochrome c] + H2O + hydrazine"}
{"X":51263,"RHEA_ID":59862,"compounds":"3-O-[N-acetyl-beta-D-glucosaminyl-(1->6)-N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP => 3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":51264,"RHEA_ID":49829,"compounds":"(5E)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,5E)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":51265,"RHEA_ID":49830,"compounds":"(2E,5E)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein] => (5E)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":51266,"RHEA_ID":49831,"compounds":"(5E)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,5E)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":51267,"RHEA_ID":49832,"compounds":"a fatty aldehyde + H2O + NAD(+) = a fatty acid + 2 H(+) + NADH"}
{"X":51268,"RHEA_ID":49833,"compounds":"a fatty aldehyde + H2O + NAD(+) => a fatty acid + 2 H(+) + NADH"}
{"X":51269,"RHEA_ID":49834,"compounds":"a fatty acid + 2 H(+) + NADH => a fatty aldehyde + H2O + NAD(+)"}
{"X":51270,"RHEA_ID":49835,"compounds":"a fatty aldehyde + H2O + NAD(+) <=> a fatty acid + 2 H(+) + NADH"}
{"X":51271,"RHEA_ID":59870,"compounds":"4-(2,4-dichlorophenoxy)butanoyl-L-glutamine + AMP + diphosphate + H(+) => 4-(2,4-dichlorophenoxy)butanoate + ATP + L-glutamine"}
{"X":51272,"RHEA_ID":49837,"compounds":"(5E)-tetradecenoyl-CoA + (R)-carnitine => (5E)-tetradecenoyl-(R)-carnitine + CoA"}
{"X":51273,"RHEA_ID":49838,"compounds":"(5E)-tetradecenoyl-(R)-carnitine + CoA => (5E)-tetradecenoyl-CoA + (R)-carnitine"}
{"X":51274,"RHEA_ID":49839,"compounds":"(5E)-tetradecenoyl-CoA + (R)-carnitine <=> (5E)-tetradecenoyl-(R)-carnitine + CoA"}
{"X":51275,"RHEA_ID":59874,"compounds":"3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP => L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":51276,"RHEA_ID":56482,"compounds":"(3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O => (4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2"}
{"X":51277,"RHEA_ID":49842,"compounds":"(-)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+) => (-)-dehydrodiconiferyl acid + 2 a quinone + H2O"}
{"X":51278,"RHEA_ID":49843,"compounds":"(-)-dehydrodiconiferyl acid + 2 a quinone + H2O <=> (-)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+)"}
{"X":51279,"RHEA_ID":59878,"compounds":"(indol-3-yl)butanoyl-L-cysteine + AMP + diphosphate + H(+) => (indol-3-yl)butanoate + ATP + L-cysteine"}
{"X":51280,"RHEA_ID":49845,"compounds":"(-)-dehydrodiconiferyl acid + a quinone => (-)-dehydrodiconiferyl acid ketone + a quinol"}
{"X":51281,"RHEA_ID":49846,"compounds":"(-)-dehydrodiconiferyl acid ketone + a quinol => (-)-dehydrodiconiferyl acid + a quinone"}
{"X":51282,"RHEA_ID":49847,"DIRECTION":"BI","MASTER_ID":49844,"metacyc":"RXN-15823","compounds":"(-)-dehydrodiconiferyl acid + a quinone <=> (-)-dehydrodiconiferyl acid ketone + a quinol"}
{"X":51283,"RHEA_ID":59882,"compounds":"3,4-dihydroxyphenylacetate + FMN + H(+) + H2O => 4-hydroxyphenylacetate + FMNH2 + O2"}
{"X":51284,"RHEA_ID":49849,"compounds":"(-)-dehydrodiconiferyl acid ketone + a quinone + H2O => (-)-dehydrodiconiferyl acid carboxylate + a quinol + H(+)"}
{"X":51285,"RHEA_ID":49850,"compounds":"(-)-dehydrodiconiferyl acid carboxylate + a quinol + H(+) => (-)-dehydrodiconiferyl acid ketone + a quinone + H2O"}
{"X":51286,"RHEA_ID":49851,"DIRECTION":"BI","MASTER_ID":49848,"metacyc":"RXN-15822","compounds":"(-)-dehydrodiconiferyl acid ketone + a quinone + H2O <=> (-)-dehydrodiconiferyl acid carboxylate + a quinol + H(+)"}
{"X":51287,"RHEA_ID":59886,"compounds":"4-chloro-L-lysine + CO2 + H2O + succinate => 2-oxoglutarate + chloride + H(+) + L-lysine + O2"}
{"X":51288,"RHEA_ID":49853,"compounds":"(3E)-octenoyl-CoA => (2E)-octenoyl-CoA"}
{"X":51289,"RHEA_ID":49854,"compounds":"(2E)-octenoyl-CoA => (3E)-octenoyl-CoA"}
{"X":51290,"RHEA_ID":49855,"compounds":"(3E)-octenoyl-CoA <=> (2E)-octenoyl-CoA"}
{"X":51291,"RHEA_ID":59890,"compounds":"A + formaldehyde + H2O + L-2-amino-4-chloropent-4-enoate + NH4(+) => 4-chloro-L-lysine + AH2 + O2"}
{"X":51292,"RHEA_ID":49857,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51293,"RHEA_ID":49858,"compounds":"(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":51294,"RHEA_ID":59893,"compounds":"L-2-amino-4-chloropent-4-enoate => chloride + H(+) + L-propargylglycine"}
{"X":51295,"RHEA_ID":59894,"compounds":"chloride + H(+) + L-propargylglycine => L-2-amino-4-chloropent-4-enoate"}
{"X":51296,"RHEA_ID":49861,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51297,"RHEA_ID":49862,"compounds":"(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":51298,"RHEA_ID":59897,"compounds":"ATP + L-glutamate + L-propargylglycine => ADP + H(+) + L-gamma-glutamyl-L-propargylglycine + phosphate"}
{"X":51299,"RHEA_ID":59898,"compounds":"ADP + H(+) + L-gamma-glutamyl-L-propargylglycine + phosphate => ATP + L-glutamate + L-propargylglycine"}
{"X":51300,"RHEA_ID":49865,"compounds":"(+)-dehydrodiconiferyl acid + 2 a quinone + H2O => (+)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+)"}
{"X":51301,"RHEA_ID":49866,"compounds":"(+)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+) => (+)-dehydrodiconiferyl acid + 2 a quinone + H2O"}
{"X":51302,"RHEA_ID":59901,"compounds":"2-oxoglutarate + L-gamma-glutamyl-L-propargylglycine + O2 => CO2 + L-gamma-glutamyl-(3R)-L-beta-ethynylserine + succinate"}
{"X":51303,"RHEA_ID":49868,"compounds":"(+)-dehydrodiconiferyl acid + a quinone = (+)-dehydrodiconiferyl acid ketone + a quinol"}
{"X":51304,"RHEA_ID":49869,"compounds":"(+)-dehydrodiconiferyl acid + a quinone => (+)-dehydrodiconiferyl acid ketone + a quinol"}
{"X":51305,"RHEA_ID":49870,"compounds":"(+)-dehydrodiconiferyl acid ketone + a quinol => (+)-dehydrodiconiferyl acid + a quinone"}
{"X":51306,"RHEA_ID":59905,"compounds":"H2O + NADP(+) + octanal => 2 H(+) + NADPH + octanoate"}
{"X":51307,"RHEA_ID":59906,"compounds":"2 H(+) + NADPH + octanoate => H2O + NADP(+) + octanal"}
{"X":51308,"RHEA_ID":49873,"compounds":"(+)-dehydrodiconiferyl acid ketone + a quinone + H2O => (+)-dehydrodiconiferyl acid carboxylate + a quinol + H(+)"}
{"X":51309,"RHEA_ID":49874,"compounds":"(+)-dehydrodiconiferyl acid carboxylate + a quinol + H(+) => (+)-dehydrodiconiferyl acid ketone + a quinone + H2O"}
{"X":51310,"RHEA_ID":59909,"compounds":"H2O + hexanal + NADP(+) => 2 H(+) + hexanoate + NADPH"}
{"X":51311,"RHEA_ID":59910,"compounds":"2 H(+) + hexanoate + NADPH => H2O + hexanal + NADP(+)"}
{"X":51312,"RHEA_ID":49877,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51313,"RHEA_ID":53184,"compounds":"1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H2O = 1-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}
{"X":51314,"RHEA_ID":59913,"compounds":"(E)-4-hydroxynon-2-enal + H2O + NADP(+) => (E)-4-hydroxynon-2-enoate + 2 H(+) + NADPH"}
{"X":51315,"RHEA_ID":59914,"compounds":"(E)-4-hydroxynon-2-enoate + 2 H(+) + NADPH => (E)-4-hydroxynon-2-enal + H2O + NADP(+)"}
{"X":51316,"RHEA_ID":49881,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51317,"RHEA_ID":49882,"compounds":"(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":51318,"RHEA_ID":59917,"compounds":"(2E)-octenal + H2O + NADP(+) => (2E)-octenoate + 2 H(+) + NADPH"}
{"X":51319,"RHEA_ID":49884,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51320,"RHEA_ID":49885,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51321,"RHEA_ID":49886,"compounds":"(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":51322,"RHEA_ID":49887,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51323,"RHEA_ID":59922,"compounds":"(2E)-octenoate + 2 H(+) + NADH => (2E)-octenal + H2O + NAD(+)"}
{"X":51324,"RHEA_ID":49889,"DIRECTION":"LR","MASTER_ID":49888,"metacyc":"RXN-12021","compounds":"(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + O2 => (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + H2O2"}
{"X":51325,"RHEA_ID":49890,"compounds":"(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + H2O2 => (1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + O2"}
{"X":51326,"RHEA_ID":59929,"compounds":"erythritol + NADP(+) => D-erythrose + H(+) + NADPH"}
{"X":51327,"RHEA_ID":59930,"compounds":"D-erythrose + H(+) + NADPH => erythritol + NADP(+)"}
{"X":51328,"RHEA_ID":49893,"DIRECTION":"LR","MASTER_ID":49892,"metacyc":"RXN-17685","compounds":"(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + O2 => (5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate + H2O2"}
{"X":51329,"RHEA_ID":49894,"compounds":"(5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate + H2O2 => (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + O2"}
{"X":51330,"RHEA_ID":59936,"compounds":"3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O = 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA + H(+)"}
{"X":51331,"RHEA_ID":49896,"compounds":"(5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate = 5,10-dihydrophenazine-1,6-dicarboxylate"}
{"X":51332,"RHEA_ID":49897,"compounds":"(5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate => 5,10-dihydrophenazine-1,6-dicarboxylate"}
{"X":51333,"RHEA_ID":49898,"compounds":"5,10-dihydrophenazine-1,6-dicarboxylate => (5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate"}
{"X":51334,"RHEA_ID":59941,"compounds":"2-methyloctadecanoyl-CoA + H2O => 2-methyloctadecanoate + CoA + H(+)"}
{"X":51335,"RHEA_ID":59942,"compounds":"2-methyloctadecanoate + CoA + H(+) => 2-methyloctadecanoyl-CoA + H2O"}
{"X":51336,"RHEA_ID":49901,"DIRECTION":"LR","MASTER_ID":49900,"metacyc":"RXN-17687","compounds":"5,10-dihydrophenazine-1,6-dicarboxylate + O2 => H2O2 + phenazine-1,6-dicarboxylate"}
{"X":51337,"RHEA_ID":49902,"compounds":"H2O2 + phenazine-1,6-dicarboxylate => 5,10-dihydrophenazine-1,6-dicarboxylate + O2"}
{"X":51338,"RHEA_ID":59949,"compounds":"H2O + prostaglandin F2alpha-CoA => CoA + H(+) + prostaglandin F2alpha"}
{"X":51339,"RHEA_ID":59950,"compounds":"CoA + H(+) + prostaglandin F2alpha => H2O + prostaglandin F2alpha-CoA"}
{"X":51340,"RHEA_ID":49905,"DIRECTION":"LR","MASTER_ID":49904,"metacyc":"RXN-17689","compounds":"(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + H(+) + O2 => (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + CO2 + H2O2"}
{"X":51341,"RHEA_ID":53212,"compounds":"17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase] = 17beta,18-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51342,"RHEA_ID":59953,"compounds":"2,6-dimethylheptanoyl-CoA + H2O => 2,6-dimethylheptanoate + CoA + H(+)"}
{"X":51343,"RHEA_ID":59954,"compounds":"2,6-dimethylheptanoate + CoA + H(+) => 2,6-dimethylheptanoyl-CoA + H2O"}
{"X":51344,"RHEA_ID":49909,"compounds":"(R)-carnitine(out) + O-acetyl-(R)-carnitine(in) => (R)-carnitine(in) + O-acetyl-(R)-carnitine(out)"}
{"X":51345,"RHEA_ID":49910,"compounds":"(R)-carnitine(in) + O-acetyl-(R)-carnitine(out) => (R)-carnitine(out) + O-acetyl-(R)-carnitine(in)"}
{"X":51346,"RHEA_ID":49911,"compounds":"(R)-carnitine(out) + O-acetyl-(R)-carnitine(in) <=> (R)-carnitine(in) + O-acetyl-(R)-carnitine(out)"}
{"X":51347,"RHEA_ID":49912,"compounds":"(R)-carnitine(out) + O-propanoyl-(R)-carnitine(in) = (R)-carnitine(in) + O-propanoyl-(R)-carnitine(out)"}
{"X":51348,"RHEA_ID":49913,"compounds":"(R)-carnitine(out) + O-propanoyl-(R)-carnitine(in) => (R)-carnitine(in) + O-propanoyl-(R)-carnitine(out)"}
{"X":51349,"RHEA_ID":49914,"compounds":"(R)-carnitine(in) + O-propanoyl-(R)-carnitine(out) => (R)-carnitine(out) + O-propanoyl-(R)-carnitine(in)"}
{"X":51350,"RHEA_ID":49915,"compounds":"(R)-carnitine(out) + O-propanoyl-(R)-carnitine(in) <=> (R)-carnitine(in) + O-propanoyl-(R)-carnitine(out)"}
{"X":51351,"RHEA_ID":59966,"compounds":"CoA + O-octanoyl-L-seryl-[protein] => L-seryl-[protein] + octanoyl-CoA"}
{"X":51352,"RHEA_ID":49917,"compounds":"(R)-carnitine(out) + O-hexadecanoyl-(R)-carnitine(in) => (R)-carnitine(in) + O-hexadecanoyl-(R)-carnitine(out)"}
{"X":51353,"RHEA_ID":49918,"compounds":"(R)-carnitine(in) + O-hexadecanoyl-(R)-carnitine(out) => (R)-carnitine(out) + O-hexadecanoyl-(R)-carnitine(in)"}
{"X":51354,"RHEA_ID":49919,"compounds":"(R)-carnitine(out) + O-hexadecanoyl-(R)-carnitine(in) <=> (R)-carnitine(in) + O-hexadecanoyl-(R)-carnitine(out)"}
{"X":51355,"RHEA_ID":59970,"compounds":"CoA + O-octanoyl-L-threonyl-[protein] => L-threonyl-[protein] + octanoyl-CoA"}
{"X":51356,"RHEA_ID":49921,"compounds":"(R)-carnitine(out) + O-octanoyl-(R)-carnitine(in) => (R)-carnitine(in) + O-octanoyl-(R)-carnitine(out)"}
{"X":51357,"RHEA_ID":49922,"compounds":"(R)-carnitine(in) + O-octanoyl-(R)-carnitine(out) => (R)-carnitine(out) + O-octanoyl-(R)-carnitine(in)"}
{"X":51358,"RHEA_ID":56564,"DIRECTION":"UN","MASTER_ID":56564,"ec":"2.4.2.42","compounds":"3-O-(beta-D-glucosyl)-L-threonyl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-threonyl-[EGF-like domain protein] + H(+) + UDP"}
{"X":51359,"RHEA_ID":59974,"compounds":"CoA + O-decanoyl-L-seryl-[protein] => decanoyl-CoA + L-seryl-[protein]"}
{"X":51360,"RHEA_ID":49925,"compounds":"(R)-carnitine(out) + O-acyl-(R)-carnitine(in) => (R)-carnitine(in) + O-acyl-(R)-carnitine(out)"}
{"X":51361,"RHEA_ID":49926,"DIRECTION":"RL","MASTER_ID":49924,"metacyc":"TRANS-RXN-177","compounds":"(R)-carnitine(in) + O-acyl-(R)-carnitine(out) => (R)-carnitine(out) + O-acyl-(R)-carnitine(in)"}
{"X":51362,"RHEA_ID":49927,"compounds":"(R)-carnitine(out) + O-acyl-(R)-carnitine(in) <=> (R)-carnitine(in) + O-acyl-(R)-carnitine(out)"}
{"X":51363,"RHEA_ID":59978,"compounds":"CO2 + toluene => 2-phenylacetate + H(+)"}
{"X":51364,"RHEA_ID":49929,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51365,"RHEA_ID":49930,"compounds":"(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":51366,"RHEA_ID":56571,"compounds":"globoside Gb4Cer + UDP-N-acetyl-alpha-D-galactosamine <=> globoside IV3GalNAc-Gb4Cer + H(+) + UDP"}
{"X":51367,"RHEA_ID":59982,"compounds":"8-oxo-dGDP + H(+) + phosphate => 8-oxo-dGTP + H2O"}
{"X":51368,"RHEA_ID":49933,"compounds":"(3E,5Z)-octadienoyl-CoA => (2E,5Z)-octadienoyl-CoA"}
{"X":51369,"RHEA_ID":53240,"compounds":"cholesta-5,7-dien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = cholesta-5,7-dien-3beta,25-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51370,"RHEA_ID":49935,"compounds":"(3E,5Z)-octadienoyl-CoA <=> (2E,5Z)-octadienoyl-CoA"}
{"X":51371,"RHEA_ID":59986,"compounds":"a carboxylate + L-glutamine => an N(2)-acyl-L-glutamine + H2O"}
{"X":51372,"RHEA_ID":49937,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51373,"RHEA_ID":56578,"compounds":"globoside Gb4Cer + H(+) + UDP => globoside Gb3Cer + UDP-N-acetyl-alpha-D-galactosamine"}
{"X":51374,"RHEA_ID":56579,"compounds":"globoside Gb3Cer + UDP-N-acetyl-alpha-D-galactosamine <=> globoside Gb4Cer + H(+) + UDP"}
{"X":51375,"RHEA_ID":59990,"DIRECTION":"RL","MASTER_ID":59988,"metacyc":"RXN-20430","compounds":"cyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH => cyclohexane-1-carbonyl-CoA + NADP(+)"}
{"X":51376,"RHEA_ID":49941,"DIRECTION":"LR","MASTER_ID":49940,"metacyc":"RXN-17690","compounds":"(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + O2 => (10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2"}
{"X":51377,"RHEA_ID":53248,"compounds":"cholesta-5,7-dien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = 3beta-hydroxycholest-5-en-7-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51378,"RHEA_ID":59992,"DIRECTION":"UN","MASTER_ID":59992,"ec":"1.3.8.15","compounds":"H(+) + oxidized [electron-transfer flavoprotein] + phloretate = reduced [electron-transfer flavoprotein] + trans-4-coumarate"}
{"X":51379,"RHEA_ID":49944,"compounds":"(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate = (1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate"}
{"X":51380,"RHEA_ID":49945,"compounds":"(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate => (1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate"}
{"X":51381,"RHEA_ID":59996,"DIRECTION":"UN","MASTER_ID":59996,"ec":"1.3.8.15","compounds":"3-phenylpropanoate + H(+) + oxidized [electron-transfer flavoprotein] = reduced [electron-transfer flavoprotein] + trans-cinnamate"}
{"X":51382,"RHEA_ID":59997,"compounds":"3-phenylpropanoate + H(+) + oxidized [electron-transfer flavoprotein] => reduced [electron-transfer flavoprotein] + trans-cinnamate"}
{"X":51383,"RHEA_ID":49948,"DIRECTION":"UN","MASTER_ID":49948,"ec":"1.10.3.16","compounds":"(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + O2 = (10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2"}
{"X":51384,"RHEA_ID":49949,"DIRECTION":"LR","MASTER_ID":49948,"metacyc":"RXN-17693","compounds":"(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + O2 => (10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2"}
{"X":51385,"RHEA_ID":60000,"DIRECTION":"UN","MASTER_ID":60000,"ec":"1.13.11.89","compounds":"hydroxymethylphosphonate + O2 = formate + 2 H(+) + phosphate"}
{"X":51386,"RHEA_ID":60001,"DIRECTION":"LR","MASTER_ID":60000,"metacyc":"RXN-20741","compounds":"hydroxymethylphosphonate + O2 => formate + 2 H(+) + phosphate"}
{"X":51387,"RHEA_ID":49952,"compounds":"(10aS)-10,10a-dihydrophenazine-1-carboxylate = 5,10-dihydrophenazine 1-carboxylate"}
{"X":51388,"RHEA_ID":49953,"DIRECTION":"LR","MASTER_ID":49952,"metacyc":"RXN-17691","compounds":"(10aS)-10,10a-dihydrophenazine-1-carboxylate => 5,10-dihydrophenazine 1-carboxylate"}
{"X":51389,"RHEA_ID":49954,"compounds":"5,10-dihydrophenazine 1-carboxylate => (10aS)-10,10a-dihydrophenazine-1-carboxylate"}
{"X":51390,"RHEA_ID":49956,"compounds":"5,10-dihydrophenazine 1-carboxylate + O2 = H2O2 + phenazine-1-carboxylate"}
{"X":51391,"RHEA_ID":49957,"DIRECTION":"LR","MASTER_ID":49956,"metacyc":"RXN-17694","compounds":"5,10-dihydrophenazine 1-carboxylate + O2 => H2O2 + phenazine-1-carboxylate"}
{"X":51392,"RHEA_ID":53264,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 2beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51393,"RHEA_ID":56599,"compounds":"(1S,4S)-bornane-2,5-dione + FMNH2 + O2 <=> (1S,4S)-5-oxo-1,2-campholide + FMN + H(+) + H2O"}
{"X":51394,"RHEA_ID":49960,"compounds":"(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + H(+) + O2 = 5,10-dihydrophenazine + CO2 + H2O2"}
{"X":51395,"RHEA_ID":49961,"DIRECTION":"LR","MASTER_ID":49960,"metacyc":"RXN-17695","compounds":"(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + H(+) + O2 => 5,10-dihydrophenazine + CO2 + H2O2"}
{"X":51396,"RHEA_ID":49962,"compounds":"5,10-dihydrophenazine + CO2 + H2O2 => (1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + H(+) + O2"}
{"X":51397,"RHEA_ID":60013,"compounds":"a tRNA with a 3' CC end + ATP => a tRNA with a 3' CCA end + diphosphate"}
{"X":51398,"RHEA_ID":49964,"compounds":"5,10-dihydrophenazine + O2 = H2O2 + phenazine"}
{"X":51399,"RHEA_ID":49965,"DIRECTION":"LR","MASTER_ID":49964,"metacyc":"RXN-17696","compounds":"5,10-dihydrophenazine + O2 => H2O2 + phenazine"}
{"X":51400,"RHEA_ID":60016,"compounds":"(2E,6E)-farnesyl diphosphate = diphosphate + sesquisabinene B"}
{"X":51401,"RHEA_ID":53273,"DIRECTION":"LR","MASTER_ID":53272,"metacyc":"RXN-14360","compounds":"5-dehydro-L-gluconate => keto-D-tagaturonate"}
{"X":51402,"RHEA_ID":49968,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51403,"RHEA_ID":49969,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51404,"RHEA_ID":49970,"compounds":"17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":51405,"RHEA_ID":49971,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51406,"RHEA_ID":60022,"compounds":"diphosphate + sesquisabinene A => (2E,6E)-farnesyl diphosphate"}
{"X":51407,"RHEA_ID":49973,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51408,"RHEA_ID":49974,"compounds":"16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":51409,"RHEA_ID":56615,"compounds":"L-cysteinyl-[protein] + NAD(+) <=> H(+) + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]"}
{"X":51410,"RHEA_ID":60026,"compounds":"(R,R)-chrysanthemol + diphosphate => (R,R)-chrysanthemyl diphosphate + H2O"}
{"X":51411,"RHEA_ID":49977,"compounds":"butanoyl-CoA + H2O => adenosine 3',5'-bisphosphate + butanoyl-4'-phosphopantetheine + 2 H(+)"}
{"X":51412,"RHEA_ID":49978,"compounds":"adenosine 3',5'-bisphosphate + butanoyl-4'-phosphopantetheine + 2 H(+) => butanoyl-CoA + H2O"}
{"X":51413,"RHEA_ID":49979,"compounds":"butanoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + butanoyl-4'-phosphopantetheine + 2 H(+)"}
{"X":51414,"RHEA_ID":60030,"compounds":"4-terpineol + diphosphate => (2E)-geranyl diphosphate + H2O"}
{"X":51415,"RHEA_ID":49981,"compounds":"H2O + hexanoyl-CoA => adenosine 3',5'-bisphosphate + 2 H(+) + hexanoyl-4'-phosphopantetheine"}
{"X":51416,"RHEA_ID":49982,"compounds":"adenosine 3',5'-bisphosphate + 2 H(+) + hexanoyl-4'-phosphopantetheine => H2O + hexanoyl-CoA"}
{"X":51417,"RHEA_ID":49983,"compounds":"H2O + hexanoyl-CoA <=> adenosine 3',5'-bisphosphate + 2 H(+) + hexanoyl-4'-phosphopantetheine"}
{"X":51418,"RHEA_ID":53290,"compounds":"5-dehydro-L-gluconate + H(+) => 3-dehydro-scyllo-inosose + H2O"}
{"X":51419,"RHEA_ID":49985,"compounds":"H(+) + jasmonate + NADPH + O2 => (1R,2R)-12-hydroxyjasmonate + H2O + NADP(+)"}
{"X":51420,"RHEA_ID":49986,"compounds":"(1R,2R)-12-hydroxyjasmonate + H2O + NADP(+) => H(+) + jasmonate + NADPH + O2"}
{"X":51421,"RHEA_ID":49987,"DIRECTION":"BI","MASTER_ID":49984,"metacyc":"RXN-17565","compounds":"H(+) + jasmonate + NADPH + O2 <=> (1R,2R)-12-hydroxyjasmonate + H2O + NADP(+)"}
{"X":51422,"RHEA_ID":53294,"compounds":"H(+) + N-carbamoyl-L-methionine => H2O + L-5-[2-(methysulfanyl)ethyl]hydantoin"}
{"X":51423,"RHEA_ID":49989,"DIRECTION":"LR","MASTER_ID":49988,"metacyc":"RXN-17567","compounds":"acetone + H(+) + NADPH + O2 => H2O + methyl acetate + NADP(+)"}
{"X":51424,"RHEA_ID":49990,"compounds":"H2O + methyl acetate + NADP(+) => acetone + H(+) + NADPH + O2"}
{"X":51425,"RHEA_ID":53298,"compounds":"(2E,4E)-decadienoyl-CoA + H(+) + NADPH => (2E)-decenoyl-CoA + NADP(+)"}
{"X":51426,"RHEA_ID":49993,"DIRECTION":"LR","MASTER_ID":49992,"metacyc":"RXN-17568","compounds":"H(+) + NADH + O2 + propane => H2O + NAD(+) + propan-2-ol"}
{"X":51427,"RHEA_ID":49994,"compounds":"H2O + NAD(+) + propan-2-ol => H(+) + NADH + O2 + propane"}
{"X":51428,"RHEA_ID":60046,"compounds":"alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer + H(+) + UDP => beta-D-Gal-(1<->1')-Cer + UDP-alpha-D-galactose"}
{"X":51429,"RHEA_ID":49997,"DIRECTION":"LR","MASTER_ID":49996,"metacyc":"RXN-17649","compounds":"cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => (25R)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":51430,"RHEA_ID":49998,"compounds":"(25R)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]"}
{"X":51431,"RHEA_ID":60049,"DIRECTION":"LR","MASTER_ID":60048,"metacyc":"RXN-20105","compounds":"a 3beta-hydroxy-4,4-dimethylsteroid + 2 H(+) + 3 NADH + 3 O2 => a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + 4 H2O + 3 NAD(+)"}
{"X":51432,"RHEA_ID":60050,"compounds":"a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + 4 H2O + 3 NAD(+) => a 3beta-hydroxy-4,4-dimethylsteroid + 2 H(+) + 3 NADH + 3 O2"}
{"X":51433,"RHEA_ID":50001,"DIRECTION":"LR","MASTER_ID":50000,"metacyc":"RXN-17638","compounds":"butane + H(+) + NADH + O2 => butan-1-ol + H2O + NAD(+)"}
{"X":51434,"RHEA_ID":50002,"compounds":"butan-1-ol + H2O + NAD(+) => butane + H(+) + NADH + O2"}
{"X":51435,"RHEA_ID":53310,"compounds":"16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":51436,"RHEA_ID":50005,"DIRECTION":"LR","MASTER_ID":50004,"metacyc":"RXN-17967","compounds":"H(+) + NADPH + O2 + tetracycline => 11a-hydroxytetracycline + H2O + NADP(+)"}
{"X":51437,"RHEA_ID":50006,"compounds":"11a-hydroxytetracycline + H2O + NADP(+) => H(+) + NADPH + O2 + tetracycline"}
{"X":51438,"RHEA_ID":53313,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 16(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51439,"RHEA_ID":51100,"compounds":"(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 16,17-epoxy-(7Z,10Z,13Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51440,"RHEA_ID":50009,"DIRECTION":"LR","MASTER_ID":50008,"metacyc":"RXN-17981","compounds":"6-methylpretetramide + 2 H(+) + NADPH + O2 => 4-hydroxy-6-methylpretetramide + H2O + NADP(+)"}
{"X":51441,"RHEA_ID":50010,"compounds":"4-hydroxy-6-methylpretetramide + H2O + NADP(+) => 6-methylpretetramide + 2 H(+) + NADPH + O2"}
{"X":51442,"RHEA_ID":53317,"DIRECTION":"LR","MASTER_ID":53316,"metacyc":"RXN-18771","compounds":"GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol => alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,poly-cis-undecaprenol + GDP + H(+)"}
{"X":51443,"RHEA_ID":51104,"compounds":"(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 13,14-epoxy-(7Z,10Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51444,"RHEA_ID":50013,"DIRECTION":"LR","MASTER_ID":50012,"metacyc":"RXN-17610","compounds":"H(+) + NADPH + O2 + tert-butanol => 2-methylpropane-1,2-diol + H2O + NADP(+)"}
{"X":51445,"RHEA_ID":50014,"compounds":"2-methylpropane-1,2-diol + H2O + NADP(+) => H(+) + NADPH + O2 + tert-butanol"}
{"X":51446,"RHEA_ID":60064,"compounds":"a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + NADH + O2 = a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + H2O + NAD(+)"}
{"X":51447,"RHEA_ID":53322,"compounds":"alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,polycis-undecaprenol + 2 GDP + 2 H(+) => alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,poly-cis-undecaprenol + 2 GDP-alpha-D-mannose"}
{"X":51448,"RHEA_ID":50017,"compounds":"H2O + octanoyl-CoA => adenosine 3',5'-bisphosphate + 2 H(+) + octanoyl-4'-phosphopantetheine"}
{"X":51449,"RHEA_ID":50018,"compounds":"adenosine 3',5'-bisphosphate + 2 H(+) + octanoyl-4'-phosphopantetheine => H2O + octanoyl-CoA"}
{"X":51450,"RHEA_ID":60068,"DIRECTION":"UN","MASTER_ID":60068,"ec":"1.14.13.246","compounds":"4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H(+) + 3 NADH + 3 O2 = 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 4 H2O + 3 NAD(+)"}
{"X":51451,"RHEA_ID":60069,"DIRECTION":"LR","MASTER_ID":60068,"metacyc":"RXN-20115","compounds":"4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H(+) + 3 NADH + 3 O2 => 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 4 H2O + 3 NAD(+)"}
{"X":51452,"RHEA_ID":60070,"compounds":"4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 4 H2O + 3 NAD(+) => 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H(+) + 3 NADH + 3 O2"}
{"X":51453,"RHEA_ID":50022,"compounds":"adenosine 3',5'-bisphosphate + decanoyl-4'-phosphopantetheine + 2 H(+) => decanoyl-CoA + H2O"}
{"X":51454,"RHEA_ID":50023,"compounds":"decanoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + decanoyl-4'-phosphopantetheine + 2 H(+)"}
{"X":51455,"RHEA_ID":53330,"compounds":"2,3-diacyl-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP => H2O + UDP-2,3-diacyl-alpha-D-glucosamine"}
{"X":51456,"RHEA_ID":60074,"compounds":"4beta-hydroxymethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + H2O + NAD(+) => 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADH + O2"}
{"X":51457,"RHEA_ID":50026,"compounds":"adenosine 3',5'-bisphosphate + dodecanoyl-4'-phosphopantetheine + 2 H(+) => dodecanoyl-CoA + H2O"}
{"X":51458,"RHEA_ID":60076,"compounds":"4beta-hydroxymethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADH + O2 = 4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H2O + NAD(+)"}
{"X":51459,"RHEA_ID":53334,"compounds":"2-[15(S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-glycerol => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2"}
{"X":51460,"RHEA_ID":51121,"compounds":"(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 AH2 => (8S,15S)-dihydroxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 A + 2 H2O"}
{"X":51461,"RHEA_ID":50030,"compounds":"adenosine 3',5'-bisphosphate + 2 H(+) + tetradecanoyl-4'-phosphopantetheine => H2O + tetradecanoyl-CoA"}
{"X":51462,"RHEA_ID":50031,"compounds":"H2O + tetradecanoyl-CoA <=> adenosine 3',5'-bisphosphate + 2 H(+) + tetradecanoyl-4'-phosphopantetheine"}
{"X":51463,"RHEA_ID":50032,"compounds":"H2O + hexadecanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + hexadecanoyl-4'-phosphopantetheine"}
{"X":51464,"RHEA_ID":60082,"compounds":"4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + H2O + NAD(+) => 4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADH + O2"}
{"X":51465,"RHEA_ID":50034,"compounds":"adenosine 3',5'-bisphosphate + 2 H(+) + hexadecanoyl-4'-phosphopantetheine => H2O + hexadecanoyl-CoA"}
{"X":51466,"RHEA_ID":50035,"compounds":"H2O + hexadecanoyl-CoA <=> adenosine 3',5'-bisphosphate + 2 H(+) + hexadecanoyl-4'-phosphopantetheine"}
{"X":51467,"RHEA_ID":50036,"compounds":"choloyl-CoA + H2O = adenosine 3',5'-bisphosphate + choloyl-4'-phosphopantetheine + 2 H(+)"}
{"X":51468,"RHEA_ID":60086,"compounds":"a 4alpha-methyl-3-oxosteroid + CO2 + NADH => a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NAD(+)"}
{"X":51469,"RHEA_ID":50038,"compounds":"adenosine 3',5'-bisphosphate + choloyl-4'-phosphopantetheine + 2 H(+) => choloyl-CoA + H2O"}
{"X":51470,"RHEA_ID":60088,"DIRECTION":"UN","MASTER_ID":60088,"ec":"1.1.1.417","compounds":"a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NADP(+) = a 4alpha-methyl-3-oxosteroid + CO2 + NADPH"}
{"X":51471,"RHEA_ID":50040,"compounds":"3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O = 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)"}
{"X":51472,"RHEA_ID":60090,"compounds":"a 4alpha-methyl-3-oxosteroid + CO2 + NADPH => a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NADP(+)"}
{"X":51473,"RHEA_ID":50042,"compounds":"3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+) => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O"}
{"X":51474,"RHEA_ID":60092,"DIRECTION":"UN","MASTER_ID":60092,"ec":"1.1.1.417","compounds":"4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+) = 4alpha-methyl-5alpha-cholesta-8,24-dien-3-one + CO2 + NADH"}
{"X":51475,"RHEA_ID":53350,"DIRECTION":"RL","MASTER_ID":53348,"metacyc":"RXN-12475","compounds":"H(+) + NADH + uridine(20a) in tRNA => 5,6-dihydrouridine(20a) in tRNA + NAD(+)"}
{"X":51476,"RHEA_ID":60094,"compounds":"4alpha-methyl-5alpha-cholesta-8,24-dien-3-one + CO2 + NADH => 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+)"}
{"X":51477,"RHEA_ID":50046,"compounds":"acyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+) => an acyl-CoA + H2O"}
{"X":51478,"RHEA_ID":50047,"compounds":"an acyl-CoA + H2O <=> acyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)"}
{"X":51479,"RHEA_ID":53354,"DIRECTION":"RL","MASTER_ID":53352,"metacyc":"RXN-12476","compounds":"H(+) + NADH + uridine(20b) in tRNA => 5,6-dihydrouridine(20b) in tRNA + NAD(+)"}
{"X":51480,"RHEA_ID":60098,"compounds":"4alpha-methyl-5alpha-cholesta-8,24-dien-3-one + CO2 + NADPH => 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+)"}
{"X":51481,"RHEA_ID":50050,"compounds":"ADP + cholate(out) + H(+) + phosphate => ATP + cholate(in) + H2O"}
{"X":51482,"RHEA_ID":60100,"DIRECTION":"UN","MASTER_ID":60100,"ec":"2.4.1.115","compounds":"cyanidin + UDP-alpha-D-glucose = cyanidin 3-O-beta-D-glucoside + H(+) + UDP"}
{"X":51483,"RHEA_ID":53358,"DIRECTION":"RL","MASTER_ID":53356,"metacyc":"RXN-12476","compounds":"H(+) + NADPH + uridine(20b) in tRNA => 5,6-dihydrouridine(20b) in tRNA + NADP(+)"}
{"X":51484,"RHEA_ID":60102,"compounds":"cyanidin 3-O-beta-D-glucoside + H(+) + UDP => cyanidin + UDP-alpha-D-glucose"}
{"X":51485,"RHEA_ID":50054,"compounds":"ADP + H(+) + phosphate + taurocholate(out) => ATP + H2O + taurocholate(in)"}
{"X":51486,"RHEA_ID":50055,"compounds":"ATP + H2O + taurocholate(in) <=> ADP + H(+) + phosphate + taurocholate(out)"}
{"X":51487,"RHEA_ID":53362,"DIRECTION":"RL","MASTER_ID":53360,"metacyc":"RXN-12457","compounds":"H(+) + NADPH + uridine(47) in tRNA => 5,6-dihydrouridine(47) in tRNA + NADP(+)"}
{"X":51488,"RHEA_ID":60106,"DIRECTION":"RL","MASTER_ID":60104,"metacyc":"RXN-19885","compounds":"(E)-3-(indol-3-yl)acrylate + reduced [electron-transfer flavoprotein] => 3-(1H-indol-3-yl)propanoate + H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":51489,"RHEA_ID":50058,"compounds":"ADP + glycocholate(out) + H(+) + phosphate => ATP + glycocholate(in) + H2O"}
{"X":51490,"RHEA_ID":50059,"compounds":"ATP + glycocholate(in) + H2O <=> ADP + glycocholate(out) + H(+) + phosphate"}
{"X":51491,"RHEA_ID":50060,"compounds":"ATP + glycochenodeoxycholate(in) + H2O = ADP + glycochenodeoxycholate(out) + H(+) + phosphate"}
{"X":51492,"RHEA_ID":60110,"compounds":"(E)-4-coumaroyl-CoA + H2O => (R)-3-(4-hydroxyphenyl)lactoyl-CoA"}
{"X":51493,"RHEA_ID":50062,"compounds":"ADP + glycochenodeoxycholate(out) + H(+) + phosphate => ATP + glycochenodeoxycholate(in) + H2O"}
{"X":51494,"RHEA_ID":50063,"compounds":"ATP + glycochenodeoxycholate(in) + H2O <=> ADP + glycochenodeoxycholate(out) + H(+) + phosphate"}
{"X":51495,"RHEA_ID":50064,"compounds":"ATP + H2O + taurochenodeoxycholate(in) = ADP + H(+) + phosphate + taurochenodeoxycholate(out)"}
{"X":51496,"RHEA_ID":60114,"compounds":"(E)-3-(indol-3-yl)acryloyl-CoA + H2O => (R)-3-(indol-3-yl)lactoyl-CoA"}
{"X":51497,"RHEA_ID":50066,"compounds":"ADP + H(+) + phosphate + taurochenodeoxycholate(out) => ATP + H2O + taurochenodeoxycholate(in)"}
{"X":51498,"RHEA_ID":50067,"compounds":"ATP + H2O + taurochenodeoxycholate(in) <=> ADP + H(+) + phosphate + taurochenodeoxycholate(out)"}
{"X":51499,"RHEA_ID":50068,"compounds":"ATP + glycoursodeoxycholate(in) + H2O = ADP + glycoursodeoxycholate(out) + H(+) + phosphate"}
{"X":51500,"RHEA_ID":60117,"DIRECTION":"LR","MASTER_ID":60116,"metacyc":"RXN-20740","compounds":"2-oxoglutarate + methylphosphonate + O2 => CO2 + hydroxymethylphosphonate + succinate"}
{"X":51501,"RHEA_ID":50070,"compounds":"ADP + glycoursodeoxycholate(out) + H(+) + phosphate => ATP + glycoursodeoxycholate(in) + H2O"}
{"X":51502,"RHEA_ID":50071,"compounds":"ATP + glycoursodeoxycholate(in) + H2O <=> ADP + glycoursodeoxycholate(out) + H(+) + phosphate"}
{"X":51503,"RHEA_ID":50072,"compounds":"ATP + H2O + tauroursodeoxycholate(in) = ADP + H(+) + phosphate + tauroursodeoxycholate(out)"}
{"X":51504,"RHEA_ID":60121,"DIRECTION":"LR","MASTER_ID":60120,"metacyc":"RXN-20720","compounds":"(2E,6E)-farnesyl diphosphate + S-adenosyl-L-methionine => H(+) + pre-sodorifen diphosphate + S-adenosyl-L-homocysteine"}
{"X":51505,"RHEA_ID":50074,"compounds":"ADP + H(+) + phosphate + tauroursodeoxycholate(out) => ATP + H2O + tauroursodeoxycholate(in)"}
{"X":51506,"RHEA_ID":50075,"compounds":"ATP + H2O + tauroursodeoxycholate(in) <=> ADP + H(+) + phosphate + tauroursodeoxycholate(out)"}
{"X":51507,"RHEA_ID":50076,"compounds":"(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51508,"RHEA_ID":53383,"compounds":"5,6-dihydrouridine(16) in tRNA + NAD(+) <=> H(+) + NADH + uridine(16) in tRNA"}
{"X":51509,"RHEA_ID":50078,"compounds":"19-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":51510,"RHEA_ID":50079,"compounds":"(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51511,"RHEA_ID":53386,"compounds":"5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADH => 5,10-methylenetetrahydromethanopterin + NAD(+)"}
{"X":51512,"RHEA_ID":60129,"compounds":"17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O => 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + H(+) + phosphate"}
{"X":51513,"RHEA_ID":50082,"compounds":"ADP + H(+) + phosphate + taurodeoxycholate(out) => ATP + H2O + taurodeoxycholate(in)"}
{"X":51514,"RHEA_ID":50083,"compounds":"ATP + H2O + taurodeoxycholate(in) <=> ADP + H(+) + phosphate + taurodeoxycholate(out)"}
{"X":51515,"RHEA_ID":50084,"compounds":"ATP + H2O + taurolithocholate sulfate(in) = ADP + H(+) + phosphate + taurolithocholate sulfate(out)"}
{"X":51516,"RHEA_ID":60133,"compounds":"a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2 => a (8S,9S)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate"}
{"X":51517,"RHEA_ID":50086,"compounds":"ADP + H(+) + phosphate + taurolithocholate sulfate(out) => ATP + H2O + taurolithocholate sulfate(in)"}
{"X":51518,"RHEA_ID":50087,"compounds":"ATP + H2O + taurolithocholate sulfate(in) <=> ADP + H(+) + phosphate + taurolithocholate sulfate(out)"}
{"X":51519,"RHEA_ID":50088,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51520,"RHEA_ID":60137,"compounds":"a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2 => a (8S,9R)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate"}
{"X":51521,"RHEA_ID":50090,"compounds":"21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":51522,"RHEA_ID":50091,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51523,"RHEA_ID":50092,"compounds":"a fatty acyl-CoA + taurine = an N-fatty acyl-taurine + CoA + H(+)"}
{"X":51524,"RHEA_ID":56733,"DIRECTION":"LR","MASTER_ID":56732,"metacyc":"RXN-18958","compounds":"4,4-dihydroxy-all-trans-beta-carotene => echinenone + H2O"}
{"X":51525,"RHEA_ID":50094,"compounds":"an N-fatty acyl-taurine + CoA + H(+) => a fatty acyl-CoA + taurine"}
{"X":51526,"RHEA_ID":50095,"compounds":"a fatty acyl-CoA + taurine <=> an N-fatty acyl-taurine + CoA + H(+)"}
{"X":51527,"RHEA_ID":50096,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 13-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51528,"RHEA_ID":60146,"compounds":"ADP + H(+) + L-gamma-glutamyl-L-glutamyl-[protein] + phosphate => ATP + L-glutamate + L-glutamyl-[protein]"}
{"X":51529,"RHEA_ID":50098,"compounds":"13-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate"}
{"X":51530,"RHEA_ID":50099,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate <=> 13-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51531,"RHEA_ID":53406,"compounds":"13-hydroxy-(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate => (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate"}
{"X":51532,"RHEA_ID":53407,"compounds":"(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate <=> 13-hydroxy-(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate"}
{"X":51533,"RHEA_ID":50102,"compounds":"CoA + H(+) + N-dodecanoyl-taurine => dodecanoyl-CoA + taurine"}
{"X":51534,"RHEA_ID":50103,"compounds":"dodecanoyl-CoA + taurine <=> CoA + H(+) + N-dodecanoyl-taurine"}
{"X":51535,"RHEA_ID":50104,"compounds":"taurine + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoyl-taurine"}
{"X":51536,"RHEA_ID":60154,"compounds":"L-glutamate + L-glutamyl-[protein] => H2O + L-gamma-glutamyl-L-glutamyl-[protein]"}
{"X":51537,"RHEA_ID":53412,"compounds":"(1R,4S)-1-hydroxylimonen-2-one + H(+) + NADPH + O2 = (4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)"}
{"X":51538,"RHEA_ID":50107,"compounds":"taurine + tetradecanoyl-CoA <=> CoA + H(+) + N-tetradecanoyl-taurine"}
{"X":51539,"RHEA_ID":50108,"compounds":"hexadecanoyl-CoA + taurine = CoA + H(+) + N-hexadecanoyl-taurine"}
{"X":51540,"RHEA_ID":50109,"compounds":"hexadecanoyl-CoA + taurine => CoA + H(+) + N-hexadecanoyl-taurine"}
{"X":51541,"RHEA_ID":53416,"compounds":"8-amino-8-demethylriboflavin + S-adenosyl-L-methionine = 8-demethyl-8-(methylamino)riboflavin + H(+) + S-adenosyl-L-homocysteine"}
{"X":51542,"RHEA_ID":50111,"compounds":"hexadecanoyl-CoA + taurine <=> CoA + H(+) + N-hexadecanoyl-taurine"}
{"X":51543,"RHEA_ID":50112,"compounds":"octadecanoyl-CoA + taurine = CoA + H(+) + N-octadecanoyl-taurine"}
{"X":51544,"RHEA_ID":50113,"compounds":"octadecanoyl-CoA + taurine => CoA + H(+) + N-octadecanoyl-taurine"}
{"X":51545,"RHEA_ID":53420,"compounds":"8-demethyl-8-(methylamino)riboflavin + S-adenosyl-L-methionine = H(+) + roseoflavin + S-adenosyl-L-homocysteine"}
{"X":51546,"RHEA_ID":50115,"compounds":"octadecanoyl-CoA + taurine <=> CoA + H(+) + N-octadecanoyl-taurine"}
{"X":51547,"RHEA_ID":50116,"compounds":"eicosanoyl-CoA + taurine = CoA + H(+) + N-eicosanoyl-taurine"}
{"X":51548,"RHEA_ID":60166,"compounds":"an N(7)-methylguanosine in RNA + S-adenosyl-L-homocysteine => a guanosine in RNA + S-adenosyl-L-methionine"}
{"X":51549,"RHEA_ID":53424,"compounds":"a sphingoid base + an acyl-CoA = CoA + H(+) + N-acyl-sphingoid base"}
{"X":51550,"RHEA_ID":50119,"compounds":"eicosanoyl-CoA + taurine <=> CoA + H(+) + N-eicosanoyl-taurine"}
{"X":51551,"RHEA_ID":50120,"compounds":"taurine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl-taurine"}
{"X":51552,"RHEA_ID":50121,"compounds":"taurine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoyl-taurine"}
{"X":51553,"RHEA_ID":53428,"DIRECTION":"UN","MASTER_ID":53428,"ec":"2.1.1.63","compounds":"a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]"}
{"X":51554,"RHEA_ID":50123,"compounds":"taurine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoyl-taurine"}
{"X":51555,"RHEA_ID":50124,"compounds":"NAD(+) + resolvin D1 = 8-oxoresolvin D1 + H(+) + NADH"}
{"X":51556,"RHEA_ID":50125,"compounds":"NAD(+) + resolvin D1 => 8-oxoresolvin D1 + H(+) + NADH"}
{"X":51557,"RHEA_ID":53432,"DIRECTION":"UN","MASTER_ID":53432,"ec":"2.4.1.86","compounds":"an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP"}
{"X":51558,"RHEA_ID":50127,"compounds":"NAD(+) + resolvin D1 <=> 8-oxoresolvin D1 + H(+) + NADH"}
{"X":51559,"RHEA_ID":50128,"compounds":"NAD(+) + resolvin D1 = 17-oxoresolvin D1 + H(+) + NADH"}
{"X":51560,"RHEA_ID":50129,"compounds":"NAD(+) + resolvin D1 => 17-oxoresolvin D1 + H(+) + NADH"}
{"X":51561,"RHEA_ID":53436,"compounds":"leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51562,"RHEA_ID":60192,"compounds":"2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + O2 = CO2 + formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + succinate"}
{"X":51563,"RHEA_ID":50132,"compounds":"ethyl hexadecanoate + H2O = ethanol + H(+) + hexadecanoate"}
{"X":51564,"RHEA_ID":50133,"compounds":"ethyl hexadecanoate + H2O => ethanol + H(+) + hexadecanoate"}
{"X":51565,"RHEA_ID":50134,"compounds":"ethanol + H(+) + hexadecanoate => ethyl hexadecanoate + H2O"}
{"X":51566,"RHEA_ID":50135,"compounds":"ethyl hexadecanoate + H2O <=> ethanol + H(+) + hexadecanoate"}
{"X":51567,"RHEA_ID":50136,"compounds":"ethyl (9Z)-octadecenoate + H2O = (9Z)-octadecenoate + ethanol + H(+)"}
{"X":51568,"RHEA_ID":53443,"compounds":"leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51569,"RHEA_ID":60199,"compounds":"2-oxoglutarate + N(6)-methyl-L-lysyl(9)-[histone H3] + O2 <=> CO2 + formaldehyde + L-lysyl(9)-[histone H3] + succinate"}
{"X":51570,"RHEA_ID":60200,"DIRECTION":"UN","MASTER_ID":60200,"ec":"1.14.11.66","compounds":"2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate"}
{"X":51571,"RHEA_ID":50140,"compounds":"(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = (14S,15S)-epoxy-(5Z,8Z,10E,12E)-eicosatetraenoate + H2O"}
{"X":51572,"RHEA_ID":56781,"DIRECTION":"LR","MASTER_ID":56780,"metacyc":"RXN-8695","compounds":"(+)-piperitol + O2 + reduced [NADPH--hemoprotein reductase] => (+)-sesamin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51573,"RHEA_ID":60203,"compounds":"2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2 <=> 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate"}
{"X":51574,"RHEA_ID":50143,"compounds":"(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate <=> (14S,15S)-epoxy-(5Z,8Z,10E,12E)-eicosatetraenoate + H2O"}
{"X":51575,"RHEA_ID":53450,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol"}
{"X":51576,"RHEA_ID":60205,"DIRECTION":"LR","MASTER_ID":60204,"metacyc":"RXN-20623","compounds":"2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + O2 => CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + succinate"}
{"X":51577,"RHEA_ID":60207,"compounds":"2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + succinate"}
{"X":51578,"RHEA_ID":50147,"compounds":"ethyl (9Z)-hexadecenoate + H2O <=> (9Z)-hexadecenoate + ethanol + H(+)"}
{"X":51579,"RHEA_ID":50148,"compounds":"a fatty acid ethyl ester + H2O = a fatty acid + ethanol + H(+)"}
{"X":51580,"RHEA_ID":60210,"compounds":"3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate => 3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 O2"}
{"X":51581,"RHEA_ID":60211,"compounds":"3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 O2 <=> 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate"}
{"X":51582,"RHEA_ID":50151,"compounds":"a fatty acid ethyl ester + H2O <=> a fatty acid + ethanol + H(+)"}
{"X":51583,"RHEA_ID":53458,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z-octadecenoate) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + cholesterol"}
{"X":51584,"RHEA_ID":53459,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + cholesterol <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z-octadecenoate)"}
{"X":51585,"RHEA_ID":60215,"compounds":"2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + succinate"}
{"X":51586,"RHEA_ID":50155,"compounds":"(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate <=> 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O"}
{"X":51587,"RHEA_ID":50156,"compounds":"N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-taurine"}
{"X":51588,"RHEA_ID":56797,"DIRECTION":"LR","MASTER_ID":56796,"ecocyc":"RXN-19335","metacyc":"RXN-19335","compounds":"[corrinoid adenosyltransferase]-cob(I)alamin + ATP => adenosylcob(III)alamin + apo-[corrinoid adenosyltransferase] + triphosphate"}
{"X":51589,"RHEA_ID":50158,"compounds":"N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-taurine => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2"}
{"X":51590,"RHEA_ID":50159,"compounds":"N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 <=> N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-taurine"}
{"X":51591,"RHEA_ID":50160,"compounds":"N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-taurine"}
{"X":51592,"RHEA_ID":56801,"DIRECTION":"LR","MASTER_ID":56800,"metacyc":"RXN-19344","compounds":"apo-[corrinoid adenosyltransferase] + cob(II)yrinate a,c diamide => cob(II)yrinate a,c diamide--[corrinoid adenosyltransferase]"}
{"X":51593,"RHEA_ID":50162,"compounds":"N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-taurine => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2"}
{"X":51594,"RHEA_ID":50163,"compounds":"N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 <=> N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-taurine"}
{"X":51595,"RHEA_ID":50164,"compounds":"(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51596,"RHEA_ID":53471,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phosphocholine + cholesterol <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z,14Z,17Z-eicosapentaenoate)"}
{"X":51597,"RHEA_ID":50166,"compounds":"20-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":51598,"RHEA_ID":60228,"compounds":"2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + O2 = CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + succinate"}
{"X":51599,"RHEA_ID":60229,"DIRECTION":"LR","MASTER_ID":60228,"metacyc":"RXN-20624","compounds":"2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + O2 => CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + succinate"}
{"X":51600,"RHEA_ID":60230,"compounds":"CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + O2"}
{"X":51601,"RHEA_ID":60231,"compounds":"2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + succinate"}
{"X":51602,"RHEA_ID":57921,"compounds":"4-phosphooxy-L-aspartyl-tRNA(Asn) + NH4(+) => H(+) + L-asparaginyl-tRNA(Asn) + phosphate"}
{"X":51603,"RHEA_ID":60233,"DIRECTION":"LR","MASTER_ID":60232,"metacyc":"RXN-20630","compounds":"2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + O2 => CO2 + formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + succinate"}
{"X":51604,"RHEA_ID":53479,"compounds":"1-hexadecanoyl-2-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (6Z,9Z,12Z)-octadecatrienoate"}
{"X":51605,"RHEA_ID":50174,"compounds":"N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-alanine => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2"}
{"X":51606,"RHEA_ID":57925,"compounds":"H2O + mutildienyl diphosphate => diphosphate + premutilin"}
{"X":51607,"RHEA_ID":53482,"compounds":"5alpha-androstane-3beta,17beta-diol + NADP(+) => 3beta-hydroxy-5alpha-androstan-17-one + H(+) + NADPH"}
{"X":51608,"RHEA_ID":50177,"compounds":"N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 => N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-gamma-aminobutanoate"}
{"X":51609,"RHEA_ID":50178,"compounds":"N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-gamma-aminobutanoate => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2"}
{"X":51610,"RHEA_ID":50179,"compounds":"N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 <=> N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-gamma-aminobutanoate"}
{"X":51611,"RHEA_ID":60241,"DIRECTION":"LR","MASTER_ID":60240,"metacyc":"RXN-20625","compounds":"2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + O2 => CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + succinate"}
{"X":51612,"RHEA_ID":60242,"compounds":"CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + O2"}
{"X":51613,"RHEA_ID":53488,"compounds":"11beta-hydroxyandrost-4-ene-3,17-dione + H(+) + NADPH = 11beta,17beta-dihydroxyandrost-4-ene-3-one + NADP(+)"}
{"X":51614,"RHEA_ID":50183,"compounds":"N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 <=> N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-gamma-aminobutanoate"}
{"X":51615,"RHEA_ID":53490,"compounds":"11beta,17beta-dihydroxyandrost-4-ene-3-one + NADP(+) => 11beta-hydroxyandrost-4-ene-3,17-dione + H(+) + NADPH"}
{"X":51616,"RHEA_ID":56825,"DIRECTION":"LR","MASTER_ID":56824,"metacyc":"RXN-15430","compounds":"AH2 + cyclooctat-9-ene-5,7-diol + O2 => A + cyclooctatin + H2O"}
{"X":51617,"RHEA_ID":50186,"compounds":"N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-alanine => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2"}
{"X":51618,"RHEA_ID":57937,"DIRECTION":"LR","MASTER_ID":57936,"metacyc":"RXN-19620","compounds":"H2O + isopyridoxal + NAD(+) => 5-pyridoxate + 2 H(+) + NADH"}
{"X":51619,"RHEA_ID":53494,"compounds":"5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na(+)(out) => 5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(in)"}
{"X":51620,"RHEA_ID":50189,"compounds":"N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 => N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycine"}
{"X":51621,"RHEA_ID":50190,"compounds":"N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycine => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2"}
{"X":51622,"RHEA_ID":50191,"compounds":"N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 <=> N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycine"}
{"X":51623,"RHEA_ID":53498,"compounds":"a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexanoate => 1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O"}
{"X":51624,"RHEA_ID":56833,"compounds":"2,6-dichlorohydroquinone + chloride + glutathione disulfide + H(+) => 2,3,6-trichlorohydroquinone + 2 glutathione"}
{"X":51625,"RHEA_ID":50194,"compounds":"3-O-(beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP => L-seryl-[protein] + UDP-alpha-D-xylose"}
{"X":51626,"RHEA_ID":56836,"DIRECTION":"UN","MASTER_ID":56836,"ec":"1.21.98.4","compounds":"[PQQ precursor protein] + S-adenosyl-L-methionine = 5'-deoxyadenosine + E-Y cross-linked-[PQQ precursor protein] + H(+) + L-methionine"}
{"X":51627,"RHEA_ID":56837,"DIRECTION":"LR","MASTER_ID":56836,"metacyc":"RXN-11176","compounds":"[PQQ precursor protein] + S-adenosyl-L-methionine => 5'-deoxyadenosine + E-Y cross-linked-[PQQ precursor protein] + H(+) + L-methionine"}
{"X":51628,"RHEA_ID":50198,"compounds":"(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2"}
{"X":51629,"RHEA_ID":53505,"DIRECTION":"LR","MASTER_ID":53504,"metacyc":"RXN-17122","compounds":"5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + AH2 + S-adenosyl-L-methionine => 5'-deoxyadenosine + 5-hydroxybenzimidazole + A + formate + 2 H(+) + L-methionine + NH4(+) + phosphate"}
{"X":51630,"RHEA_ID":56840,"DIRECTION":"UN","MASTER_ID":56840,"ec":"1.13.11.86","compounds":"5-amino-2-hydroxybenzoate + O2 = (2Z,4E)-4-amino-6-oxohepta-2,4-dienedioate + H(+)"}
{"X":51631,"RHEA_ID":56841,"DIRECTION":"LR","MASTER_ID":56840,"metacyc":"RXN-19523","compounds":"5-amino-2-hydroxybenzoate + O2 => (2Z,4E)-4-amino-6-oxohepta-2,4-dienedioate + H(+)"}
{"X":51632,"RHEA_ID":53508,"compounds":"(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione = (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate"}
{"X":51633,"RHEA_ID":60264,"compounds":"L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":51634,"RHEA_ID":53509,"DIRECTION":"LR","MASTER_ID":53508,"reactome":"R-HSA-9026780.1","compounds":"(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione => (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate"}
{"X":51635,"RHEA_ID":56845,"DIRECTION":"LR","MASTER_ID":56844,"metacyc":"RXN-19059","compounds":"nocamycin E + S-adenosyl-L-methionine => nocamycin I + S-adenosyl-L-homocysteine"}
{"X":51636,"RHEA_ID":50206,"compounds":"(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate => (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2"}
{"X":51637,"RHEA_ID":60268,"compounds":"N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":51638,"RHEA_ID":53513,"DIRECTION":"LR","MASTER_ID":53512,"reactome":"R-HSA-9026757.1","compounds":"(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O => (13R)-S-cysteinylglycinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + L-glutamate"}
{"X":51639,"RHEA_ID":50209,"compounds":"cortisol + NAD(+) => cortisone + H(+) + NADH"}
{"X":51640,"RHEA_ID":53515,"compounds":"(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O <=> (13R)-S-cysteinylglycinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + L-glutamate"}
{"X":51641,"RHEA_ID":60272,"compounds":"N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":51642,"RHEA_ID":53517,"compounds":"1-hexadecanoyl-2-(11Z,14Z,17Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol => 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (11Z,14Z,17Z)-eicosatrienoate"}
{"X":51643,"RHEA_ID":50213,"compounds":"(13S)-hydroperoxy-(9Z,11E)-octadecadienoate => 11-hydroxy-(12S,13S)-epoxy-(9Z)-octadecenoate"}
{"X":51644,"RHEA_ID":50214,"compounds":"11-hydroxy-(12S,13S)-epoxy-(9Z)-octadecenoate => (13S)-hydroperoxy-(9Z,11E)-octadecadienoate"}
{"X":51645,"RHEA_ID":50215,"compounds":"(13S)-hydroperoxy-(9Z,11E)-octadecadienoate <=> 11-hydroxy-(12S,13S)-epoxy-(9Z)-octadecenoate"}
{"X":51646,"RHEA_ID":53521,"compounds":"1-hexadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol => 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z,12Z,15Z)-octadecatrienoate"}
{"X":51647,"RHEA_ID":50217,"compounds":"(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => (8S)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate"}
{"X":51648,"RHEA_ID":50218,"compounds":"(8S)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate => (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate"}
{"X":51649,"RHEA_ID":50219,"compounds":"(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate <=> (8S)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate"}
{"X":51650,"RHEA_ID":60281,"DIRECTION":"LR","MASTER_ID":60280,"metacyc":"RXN-20599","compounds":"L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":51651,"RHEA_ID":50221,"compounds":"(S)-demethyl-4-deoxygadusol => (R)-demethyl-4-deoxygadusol"}
{"X":51652,"RHEA_ID":50222,"compounds":"(R)-demethyl-4-deoxygadusol => (S)-demethyl-4-deoxygadusol"}
{"X":51653,"RHEA_ID":60284,"compounds":"N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":51654,"RHEA_ID":50224,"DIRECTION":"UN","MASTER_ID":50224,"ec":"2.1.1.222","compounds":"3-(all-trans-hexaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = 2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine"}
{"X":51655,"RHEA_ID":56864,"DIRECTION":"UN","MASTER_ID":56864,"ec":"2.3.1.281","compounds":"12 H(+) + 6 malonyl-CoA + NADH + 5 NADPH = (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + 6 CO2 + 6 CoA + 4 H2O + NAD(+) + 5 NADP(+)"}
{"X":51656,"RHEA_ID":50226,"compounds":"2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine => 3-(all-trans-hexaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine"}
{"X":51657,"RHEA_ID":50227,"compounds":"3-(all-trans-hexaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> 2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine"}
{"X":51658,"RHEA_ID":53533,"compounds":"(14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate => (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O"}
{"X":51659,"RHEA_ID":56868,"DIRECTION":"UN","MASTER_ID":56868,"ec":"2.3.1.273","compounds":"(2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + octanoyl-CoA = (2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + CoA"}
{"X":51660,"RHEA_ID":50230,"compounds":"benzene-1,2,4-triol + FAD + H(+) + H2O => FADH2 + O2 + resorcinol"}
{"X":51661,"RHEA_ID":60292,"DIRECTION":"UN","MASTER_ID":60292,"ec":"2.1.1.356","compounds":"L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine"}
{"X":51662,"RHEA_ID":61602,"DIRECTION":"RL","MASTER_ID":61600,"metacyc":"RXN-20057","compounds":"[DsbB protein]-dithiol + [protein]-disulfide => [DsbD protein]-disulfide + [protein]-dithiol"}
{"X":51663,"RHEA_ID":60294,"compounds":"3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine => L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine"}
{"X":51664,"RHEA_ID":50234,"compounds":"biliverdin IXalpha + CO + Fe(2+) + 3 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => 8 H(+) + heme b + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]"}
{"X":51665,"RHEA_ID":60296,"compounds":"L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":51666,"RHEA_ID":60297,"DIRECTION":"LR","MASTER_ID":60296,"metacyc":"RXN-20600","compounds":"L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":51667,"RHEA_ID":60298,"compounds":"H(+) + N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine => L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine"}
{"X":51668,"RHEA_ID":50238,"compounds":"17alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + pregnenolone + reduced [NADPH--hemoprotein reductase]"}
{"X":51669,"RHEA_ID":50239,"compounds":"O2 + pregnenolone + reduced [NADPH--hemoprotein reductase] <=> 17alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51670,"RHEA_ID":60301,"DIRECTION":"LR","MASTER_ID":60300,"metacyc":"RXN-20606","compounds":"N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":51671,"RHEA_ID":56880,"compounds":"a 3beta-hydroxy-Delta(5)-steroid + NADP(+) = a 3-oxo-Delta(5)-steroid + H(+) + NADPH"}
{"X":51672,"RHEA_ID":50242,"compounds":"n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine + H2O => [hyaluronan](n)"}
{"X":51673,"RHEA_ID":60305,"DIRECTION":"LR","MASTER_ID":60304,"metacyc":"RXN-20612","compounds":"N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":51674,"RHEA_ID":53550,"compounds":"Delta(12)-prostaglandin J2 => prostaglandin J2"}
{"X":51675,"RHEA_ID":54653,"compounds":"peregrinol diphosphate => all-trans-geranylgeranyl diphosphate + H2O"}
{"X":51676,"RHEA_ID":50246,"compounds":"3beta-hydroxyandrost-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17alpha-hydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":51677,"RHEA_ID":56887,"compounds":"adenosine(32) in tRNA + S-adenosyl-L-methionine <=> 2'-O-methyladenosine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":51678,"RHEA_ID":56888,"compounds":"UDP-4-dehydro-6-deoxy-alpha-D-glucose = UDP-4-dehydro-beta-L-rhamnose"}
{"X":51679,"RHEA_ID":50249,"compounds":"ATP + D-ribose 5-phosphate + H(+) => ADP-D-ribose + diphosphate"}
{"X":51680,"RHEA_ID":50250,"DIRECTION":"RL","MASTER_ID":50248,"metacyc":"RXN-17997","compounds":"ADP-D-ribose + diphosphate => ATP + D-ribose 5-phosphate + H(+)"}
{"X":51681,"RHEA_ID":56891,"DIRECTION":"BI","MASTER_ID":56888,"metacyc":"RXN-18332","compounds":"UDP-4-dehydro-6-deoxy-alpha-D-glucose <=> UDP-4-dehydro-beta-L-rhamnose"}
{"X":51682,"RHEA_ID":60314,"compounds":"H(+) + N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine => L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine"}
{"X":51683,"RHEA_ID":50253,"compounds":"an acyl-CoA + H(+) + malonyl-CoA => a 3-oxoacyl-CoA + CO2 + CoA"}
{"X":51684,"RHEA_ID":61628,"compounds":"5-aminopentanal = 1-piperideine + H2O"}
{"X":51685,"RHEA_ID":56895,"compounds":"H(+) + NADPH + UDP-4-dehydro-beta-L-rhamnose <=> NADP(+) + UDP-beta-L-rhamnose"}
{"X":51686,"RHEA_ID":60318,"compounds":"H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine"}
{"X":51687,"RHEA_ID":54665,"DIRECTION":"LR","MASTER_ID":54664,"metacyc":"RXN-19013","compounds":"(3S,22S)-2,3:22,23-diepoxy-2,3,22,23-tetrahydrosqualene => pre-alpha-onocerin"}
{"X":51688,"RHEA_ID":58008,"DIRECTION":"UN","MASTER_ID":58008,"ec":"2.4.1.366","compounds":"(20S)-ginsenoside F1 + UDP-alpha-D-glucose = (20S)-ginsenoside Rg1 + H(+) + UDP"}
{"X":51689,"RHEA_ID":60321,"DIRECTION":"LR","MASTER_ID":60320,"metacyc":"RXN-20613","compounds":"N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":51690,"RHEA_ID":60322,"compounds":"H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine"}
{"X":51691,"RHEA_ID":50261,"compounds":"11(S)-hydroxy-14(S),15(S)-epoxy-(5Z,8Z,12E)-eicosatrienoate + glutathione => (11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate"}
{"X":51692,"RHEA_ID":50262,"compounds":"(11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate => 11(S)-hydroxy-14(S),15(S)-epoxy-(5Z,8Z,12E)-eicosatrienoate + glutathione"}
{"X":51693,"RHEA_ID":50263,"compounds":"11(S)-hydroxy-14(S),15(S)-epoxy-(5Z,8Z,12E)-eicosatrienoate + glutathione <=> (11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate"}
{"X":51694,"RHEA_ID":60326,"compounds":"3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine => L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine"}
{"X":51695,"RHEA_ID":53571,"compounds":"12,13-epoxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-12,13-epoxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51696,"RHEA_ID":54674,"compounds":"(+)-kolavelool + diphosphate => (+)-kolavenyl diphosphate + H2O"}
{"X":51697,"RHEA_ID":53573,"compounds":"8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51698,"RHEA_ID":56908,"DIRECTION":"UN","MASTER_ID":56908,"ec":"4.2.99.24","compounds":"(7S)-O-acetylsalutaridinol = acetate + H(+) + thebaine"}
{"X":51699,"RHEA_ID":50269,"compounds":"(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate => (5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O"}
{"X":51700,"RHEA_ID":50270,"compounds":"(5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O => (5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate"}
{"X":51701,"RHEA_ID":60332,"compounds":"L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":51702,"RHEA_ID":60334,"compounds":"H(+) + N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine => L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine"}
{"X":51703,"RHEA_ID":50273,"compounds":"(5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O => resolvin E1"}
{"X":51704,"RHEA_ID":60336,"compounds":"N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":51705,"RHEA_ID":60337,"DIRECTION":"LR","MASTER_ID":60336,"metacyc":"RXN-20608","compounds":"N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":51706,"RHEA_ID":60338,"compounds":"H(+) + N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine"}
{"X":51707,"RHEA_ID":50277,"compounds":"(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 => (12S)-hydroperoxy-(14R,15S)-epoxy-(5Z,8Z,10E)-eicosatrienoate"}
{"X":51708,"RHEA_ID":61665,"DIRECTION":"LR","MASTER_ID":61664,"metacyc":"RXN-12325","compounds":"(2E,6E,10E)-geranylgeraniol + ATP => (2E,6E,10E)-geranylgeranyl phosphate + ADP + H(+)"}
{"X":51709,"RHEA_ID":60341,"DIRECTION":"LR","MASTER_ID":60340,"metacyc":"RXN-20614","compounds":"N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":51710,"RHEA_ID":60342,"compounds":"H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine"}
{"X":51711,"RHEA_ID":50281,"compounds":"(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 => (5S)-hydroperoxy-(14R,15S)-epoxy-(6E,8Z,11Z)-eicosatrienoate"}
{"X":51712,"RHEA_ID":50282,"compounds":"(5S)-hydroperoxy-(14R,15S)-epoxy-(6E,8Z,11Z)-eicosatrienoate => (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2"}
{"X":51713,"RHEA_ID":60345,"DIRECTION":"LR","MASTER_ID":60344,"metacyc":"RXN-20603","compounds":"L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine"}
{"X":51714,"RHEA_ID":60346,"compounds":"H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine => L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine"}
{"X":51715,"RHEA_ID":50285,"compounds":"(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 => (12S)-hydroperoxy-(14S,15R)-epoxy-(5Z,8Z,10E)-eicosatrienoate"}
{"X":51716,"RHEA_ID":50286,"compounds":"(12S)-hydroperoxy-(14S,15R)-epoxy-(5Z,8Z,10E)-eicosatrienoate => (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2"}
{"X":51717,"RHEA_ID":60349,"DIRECTION":"LR","MASTER_ID":60348,"metacyc":"RXN-20609","compounds":"N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine"}
{"X":51718,"RHEA_ID":50288,"compounds":"(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (8S)-hydroperoxy-(14S,15R)-epoxy-(5Z,9E,11Z)-eicosatrienoate"}
{"X":51719,"RHEA_ID":60351,"compounds":"N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine"}
{"X":51720,"RHEA_ID":50290,"compounds":"(8S)-hydroperoxy-(14S,15R)-epoxy-(5Z,9E,11Z)-eicosatrienoate => (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2"}
{"X":51721,"RHEA_ID":56931,"compounds":"abieta-7,13-dien-18-al + O2 + reduced [NADPH--hemoprotein reductase] <=> abieta-7,13-dien-18-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51722,"RHEA_ID":50292,"DIRECTION":"UN","MASTER_ID":50292,"ec":"1.14.19.53","compounds":"all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = all-trans-3,4-didehydroretinol + 2 H2O + 2 oxidized [adrenodoxin]"}
{"X":51723,"RHEA_ID":60355,"compounds":"2-heptyl-3-hydroxy-4(1H)-quinolone + O2 <=> CO + H(+) + N-octanoylanthranilate"}
{"X":51724,"RHEA_ID":61721,"DIRECTION":"LR","MASTER_ID":61720,"ecocyc":"RXN-20680","metacyc":"RXN-20680","compounds":"a D-guloside + NAD(+) => a 3-dehydro-D-guloside + H(+) + NADH"}
{"X":51725,"RHEA_ID":53601,"compounds":"1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate"}
{"X":51726,"RHEA_ID":50296,"compounds":"N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + O2 + reduced [NADPH--hemoprotein reductase] = 2-oxo-N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51727,"RHEA_ID":60359,"compounds":"H2O + N-octanoylanthranilate <=> anthranilate + H(+) + octanoate"}
{"X":51728,"RHEA_ID":50298,"compounds":"2-oxo-N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":51729,"RHEA_ID":50299,"compounds":"N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-oxo-N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51730,"RHEA_ID":60362,"DIRECTION":"RL","MASTER_ID":60360,"metacyc":"RXN-20703","compounds":"dehydro F420-0 + FMNH2 => FMN + H(+) + oxidized F420-0"}
{"X":51731,"RHEA_ID":60363,"compounds":"FMN + H(+) + oxidized F420-0 <=> dehydro F420-0 + FMNH2"}
{"X":51732,"RHEA_ID":50302,"compounds":"all-trans-4-hydroxyretinol + H2O + 2 oxidized [adrenodoxin] => all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}
{"X":51733,"RHEA_ID":50303,"compounds":"all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> all-trans-4-hydroxyretinol + H2O + 2 oxidized [adrenodoxin]"}
{"X":51734,"RHEA_ID":60366,"DIRECTION":"RL","MASTER_ID":60364,"reactome":"R-HSA-429101.1","compounds":"H(+)(in) + myo-inositol(in) => H(+)(out) + myo-inositol(out)"}
{"X":51735,"RHEA_ID":50305,"compounds":"O2 + progesterone + reduced [NADPH--hemoprotein reductase] => 21-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51736,"RHEA_ID":50306,"compounds":"21-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + progesterone + reduced [NADPH--hemoprotein reductase]"}
{"X":51737,"RHEA_ID":50307,"compounds":"O2 + progesterone + reduced [NADPH--hemoprotein reductase] <=> 21-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51738,"RHEA_ID":60370,"DIRECTION":"RL","MASTER_ID":60368,"reactome":"R-HSA-429036.1","compounds":"urate(in) => urate(out)"}
{"X":51739,"RHEA_ID":56949,"compounds":"pyruvate + UTP => H(+) + phosphoenolpyruvate + UDP"}
{"X":51740,"RHEA_ID":50310,"compounds":"11-deoxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":51741,"RHEA_ID":50311,"compounds":"17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-deoxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51742,"RHEA_ID":53618,"compounds":"(+)-isoafricanol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}
{"X":51743,"RHEA_ID":56953,"compounds":"CTP + pyruvate => CDP + H(+) + phosphoenolpyruvate"}
{"X":51744,"RHEA_ID":50314,"compounds":"butanal + CO2 => 2-oxopentanoate + H(+)"}
{"X":51745,"RHEA_ID":50315,"compounds":"2-oxopentanoate + H(+) <=> butanal + CO2"}
{"X":51746,"RHEA_ID":56956,"DIRECTION":"UN","MASTER_ID":56956,"ec":"2.7.1.40","compounds":"ITP + pyruvate = H(+) + IDP + phosphoenolpyruvate"}
{"X":51747,"RHEA_ID":60379,"compounds":"D-glucose(out) <=> D-glucose(in)"}
{"X":51748,"RHEA_ID":50318,"compounds":"ethanol + H(+) + octadecanoate => ethyl octadecanoate + H2O"}
{"X":51749,"RHEA_ID":50319,"compounds":"ethyl octadecanoate + H2O <=> ethanol + H(+) + octadecanoate"}
{"X":51750,"RHEA_ID":60382,"DIRECTION":"RL","MASTER_ID":60380,"reactome":"R-HSA-198818.3","compounds":"L-dehydroascorbate(in) => L-dehydroascorbate(out)"}
{"X":51751,"RHEA_ID":60383,"compounds":"L-dehydroascorbate(out) <=> L-dehydroascorbate(in)"}
{"X":51752,"RHEA_ID":50322,"compounds":"1-[(9R,10S)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":51753,"RHEA_ID":50323,"compounds":"a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] <=> 1-[(9R,10S)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51754,"RHEA_ID":60386,"compounds":"N-(2,3-dihydroxybenzoyl)-L-serine trimer => enterobactin + H2O"}
{"X":51755,"RHEA_ID":54737,"DIRECTION":"LR","MASTER_ID":54736,"metacyc":"RXN-13226","compounds":"N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine => 2 H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine"}
{"X":51756,"RHEA_ID":50326,"compounds":"1-[(9S,10R)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":51757,"RHEA_ID":50327,"compounds":"a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] <=> 1-[(9S,10R)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51758,"RHEA_ID":60390,"compounds":"Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) => Fe(III)-di(C-5-deoxy-beta-D-glucosyl)-enterobactin + H2O"}
{"X":51759,"RHEA_ID":56969,"compounds":"dCTP + pyruvate => dCDP + H(+) + phosphoenolpyruvate"}
{"X":51760,"RHEA_ID":50330,"compounds":"1-[8-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":51761,"RHEA_ID":50331,"compounds":"a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] <=> 1-[8-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51762,"RHEA_ID":50332,"compounds":"a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] = 1-[11-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51763,"RHEA_ID":60395,"compounds":"Fe(III)-C-5-deoxy-beta-D-glucosyl-enterobactin + H2O <=> Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+)"}
{"X":51764,"RHEA_ID":50334,"compounds":"1-[11-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":51765,"RHEA_ID":50335,"compounds":"a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] <=> 1-[11-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51766,"RHEA_ID":60398,"compounds":"Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine => Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O"}
{"X":51767,"RHEA_ID":56977,"DIRECTION":"LR","MASTER_ID":56976,"metacyc":"RXN-16204","compounds":"4-methylphenol + H2O + 2 oxidized [azurin] => 4-hydroxybenzyl alcohol + 2 H(+) + 2 reduced [azurin]"}
{"X":51768,"RHEA_ID":50338,"compounds":"H(+) + H2O + omega-hydroxy-triacontanoate + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + triacontanoate"}
{"X":51769,"RHEA_ID":50339,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + triacontanoate <=> H(+) + H2O + omega-hydroxy-triacontanoate + oxidized [NADPH--hemoprotein reductase]"}
{"X":51770,"RHEA_ID":60414,"compounds":"[N-(2,3-dihydroxybenzoyl)-L-seryl]2-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine + H(+) => H2O + monoglucosyl-enterobactin"}
{"X":51771,"RHEA_ID":56981,"DIRECTION":"LR","MASTER_ID":56980,"metacyc":"RXN-16205","compounds":"4-hydroxybenzyl alcohol + 2 oxidized [azurin] => 4-hydroxybenzaldehyde + 2 H(+) + 2 reduced [azurin]"}
{"X":51772,"RHEA_ID":50342,"compounds":"1alpha-hydroxytestosterone + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + testosterone"}
{"X":51773,"RHEA_ID":60417,"DIRECTION":"LR","MASTER_ID":60416,"metacyc":"RXN-20003","compounds":"diglucosyl-enterobactin + H2O => H(+) + N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2"}
{"X":51774,"RHEA_ID":60418,"compounds":"H(+) + N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 => diglucosyl-enterobactin + H2O"}
{"X":51775,"RHEA_ID":60420,"DIRECTION":"UN","MASTER_ID":60420,"ec":"3.1.1.107","compounds":"H2O + triglucosyl-enterobactin = [N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]3 + H(+)"}
{"X":51776,"RHEA_ID":50347,"compounds":"3 (S)-methylmalonyl-CoA + a holo-[mycolipanoate synthase] + a long-chain fatty acyl-CoA + 9 H(+) + 6 NADPH <=> a long-chain mycolipanoyl-[mycolipanoate synthase] + 3 CO2 + 4 CoA + 3 H2O + 6 NADP(+)"}
{"X":51777,"RHEA_ID":60422,"compounds":"[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]3 + H(+) => H2O + triglucosyl-enterobactin"}
{"X":51778,"RHEA_ID":53655,"compounds":"(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (5S,15S)-dihydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate"}
{"X":51779,"RHEA_ID":50350,"compounds":"dolichyl diphosphate + H(+) + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein]"}
{"X":51780,"RHEA_ID":60426,"compounds":"diphosphate + valerianol => (2E,6E)-farnesyl diphosphate + H2O"}
{"X":51781,"RHEA_ID":53659,"compounds":"(5S,6R)-dihydroxy-(7E,9E,11Z,14Z)-eicosatetraenoate + O2 <=> (5S,6R)-dihydroxy-(15S)-hydroperoxy-(7E,9E,11Z,13E)-eicosatetraenoate"}
{"X":51782,"RHEA_ID":50354,"compounds":"a trimethylated-mycocerosoyl-[mycocerosate synthase] + 3 CO2 + 3 CoA + 3 H2O + 6 NADP(+) => 3 (R)-methylmalonyl-CoA + a long-chain acyl-[mycocerosate synthase] + 9 H(+) + 6 NADPH"}
{"X":51783,"RHEA_ID":50355,"compounds":"3 (R)-methylmalonyl-CoA + a long-chain acyl-[mycocerosate synthase] + 9 H(+) + 6 NADPH <=> a trimethylated-mycocerosoyl-[mycocerosate synthase] + 3 CO2 + 3 CoA + 3 H2O + 6 NADP(+)"}
{"X":51784,"RHEA_ID":60430,"compounds":"(indol-3-yl)acetate + L-aspartate => (indol-3-yl)acetyl-L-aspartate + H2O"}
{"X":51785,"RHEA_ID":53663,"compounds":"(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (5S)-hydroxy-(15S)-hydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate"}
{"X":51786,"RHEA_ID":58108,"compounds":"H2O + N(6)-acetyl-L-lysyl-[protein] = acetate + L-lysyl-[protein]"}
{"X":51787,"RHEA_ID":54771,"compounds":"[LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine <=> [LarE protein]-dehydroalanine + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide"}
{"X":51788,"RHEA_ID":60438,"compounds":"3-methylbutanol + acetate + H(+) => 3-methylbutyl acetate + H2O"}
{"X":51789,"RHEA_ID":60439,"compounds":"3-methylbutyl acetate + H2O <=> 3-methylbutanol + acetate + H(+)"}
{"X":51790,"RHEA_ID":50362,"compounds":"benzoyl cyanide + H2O2 => (R)-mandelonitrile + O2"}
{"X":51791,"RHEA_ID":60441,"DIRECTION":"LR","MASTER_ID":60440,"metacyc":"RXN-17572","compounds":"H2O + methyl acetate => acetate + H(+) + methanol"}
{"X":51792,"RHEA_ID":60442,"compounds":"acetate + H(+) + methanol => H2O + methyl acetate"}
{"X":51793,"RHEA_ID":60444,"DIRECTION":"UN","MASTER_ID":60444,"ec":"3.4.13.23","compounds":"an S-substitued L-cysteinylglycine + H2O = an S-substituted L-cysteine + glycine"}
{"X":51794,"RHEA_ID":60445,"DIRECTION":"LR","MASTER_ID":60444,"metacyc":"RXN-6642","compounds":"an S-substitued L-cysteinylglycine + H2O => an S-substituted L-cysteine + glycine"}
{"X":51795,"RHEA_ID":50368,"DIRECTION":"UN","MASTER_ID":50368,"ec":"1.14.19.48","compounds":"2-methylbutan-2-ol + H(+) + NADPH + O2 = 3-hydroxy-3-methylbut-1-ene + 2 H2O + NADP(+)"}
{"X":51796,"RHEA_ID":53675,"compounds":"2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + AH2 + O2 <=> 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphoethanolamine + A + H2O"}
{"X":51797,"RHEA_ID":50370,"compounds":"3-hydroxy-3-methylbut-1-ene + 2 H2O + NADP(+) => 2-methylbutan-2-ol + H(+) + NADPH + O2"}
{"X":51798,"RHEA_ID":60458,"compounds":"3',3'-cUAMP + 2 diphosphate => ATP + UTP"}
{"X":51799,"RHEA_ID":53679,"compounds":"2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 <=> 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O"}
{"X":51800,"RHEA_ID":60460,"compounds":"(6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) = (6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)"}
{"X":51801,"RHEA_ID":50375,"compounds":"an N-acylsphingoid base 1-phosphate(in) <=> an N-acylsphingoid base 1-phosphate(out)"}
{"X":51802,"RHEA_ID":60462,"compounds":"(6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out) => (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in)"}
{"X":51803,"RHEA_ID":50377,"compounds":"a ceramide(in) + ATP + H2O => a ceramide(out) + ADP + H(+) + phosphate"}
{"X":51804,"RHEA_ID":54790,"compounds":"[LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide => [LarE protein]-L-cysteine + ATP + pyridinium-3,5-dicarboxylate mononucleotide"}
{"X":51805,"RHEA_ID":60465,"compounds":"2',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) => 2',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)"}
{"X":51806,"RHEA_ID":50380,"DIRECTION":"UN","MASTER_ID":50380,"ec":"2.3.1.253","compounds":"3 H(+) + 3 malonyl-CoA = 1,3,5-trihydroxybenzene + 3 CO2 + 3 CoA"}
{"X":51807,"RHEA_ID":50381,"DIRECTION":"LR","MASTER_ID":50380,"metacyc":"RXN-17845","compounds":"3 H(+) + 3 malonyl-CoA => 1,3,5-trihydroxybenzene + 3 CO2 + 3 CoA"}
{"X":51808,"RHEA_ID":50382,"compounds":"1,3,5-trihydroxybenzene + 3 CO2 + 3 CoA => 3 H(+) + 3 malonyl-CoA"}
{"X":51809,"RHEA_ID":61834,"compounds":"H(+) + sitosteryl 3-beta-D-glucoside + UDP => (24R)-ethylcholest-5-en-3beta-ol + UDP-alpha-D-glucose"}
{"X":51810,"RHEA_ID":60470,"compounds":"3',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out) => 3',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in)"}
{"X":51811,"RHEA_ID":50385,"compounds":"H(+) + oxidized coenzyme F420-(gamma-Glu)(n) + tetracycline => 5a,11a-dehydrotetracycline + reduced coenzyme F420-(gamma-Glu)(n)"}
{"X":51812,"RHEA_ID":50386,"DIRECTION":"RL","MASTER_ID":50384,"metacyc":"RXN-17988","compounds":"5a,11a-dehydrotetracycline + reduced coenzyme F420-(gamma-Glu)(n) => H(+) + oxidized coenzyme F420-(gamma-Glu)(n) + tetracycline"}
{"X":51813,"RHEA_ID":60472,"compounds":"5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) + 5-formyltetrahydrofolate(out) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out) + 5-formyltetrahydrofolate(in)"}
{"X":51814,"RHEA_ID":60474,"compounds":"5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out) + 5-formyltetrahydrofolate(in) => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) + 5-formyltetrahydrofolate(out)"}
{"X":51815,"RHEA_ID":60475,"compounds":"5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) + 5-formyltetrahydrofolate(out) <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out) + 5-formyltetrahydrofolate(in)"}
{"X":51816,"RHEA_ID":50390,"compounds":"5a,11a-dehydrooxytetracycline + H2O + NADP(+) => 5a,11a-dehydrotetracycline + H(+) + NADPH + O2"}
{"X":51817,"RHEA_ID":50391,"compounds":"5a,11a-dehydrotetracycline + H(+) + NADPH + O2 <=> 5a,11a-dehydrooxytetracycline + H2O + NADP(+)"}
{"X":51818,"RHEA_ID":60478,"compounds":"cyclic AMP-AMP-GMP + 3 diphosphate => 2 ATP + GTP"}
{"X":51819,"RHEA_ID":60479,"compounds":"2 ATP + GTP <=> cyclic AMP-AMP-GMP + 3 diphosphate"}
{"X":51820,"RHEA_ID":50394,"compounds":"5a,11a-dehydrooxytetracycline + reduced coenzyme F420-(gamma-Glu)(n) => H(+) + oxidized coenzyme F420-(gamma-Glu)(n) + oxytetracycline"}
{"X":51821,"RHEA_ID":57035,"compounds":"(E)-2-((N-methylformamido) methylene)succinate + H(+) + 2 H2O <=> CO2 + formate + methylamine + succinate semialdehyde"}
{"X":51822,"RHEA_ID":50396,"DIRECTION":"UN","MASTER_ID":50396,"ec":"2.3.1.230","compounds":"(2-aminobenzoyl)acetate + H(+) + octanoyl-CoA = 2-heptyl-4(1H)-quinolone + CO2 + CoA + H2O"}
{"X":51823,"RHEA_ID":60483,"compounds":"2 UTP <=> c-di-UMP + 2 diphosphate"}
{"X":51824,"RHEA_ID":50398,"compounds":"2-heptyl-4(1H)-quinolone + CO2 + CoA + H2O => (2-aminobenzoyl)acetate + H(+) + octanoyl-CoA"}
{"X":51825,"RHEA_ID":53705,"compounds":"2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine + H2O => H(+) + prostaglandin E2 + sn-glycero-3-phosphoethanolamine"}
{"X":51826,"RHEA_ID":50400,"compounds":"L-cysteinyl-[PqsC protein] + octanoyl-CoA = CoA + S-octanoyl-L-cysteinyl-[PqsC protein]"}
{"X":51827,"RHEA_ID":60487,"compounds":"CTP + UTP <=> cyclic CMP-UMP + 2 diphosphate"}
{"X":51828,"RHEA_ID":50402,"compounds":"CoA + S-octanoyl-L-cysteinyl-[PqsC protein] => L-cysteinyl-[PqsC protein] + octanoyl-CoA"}
{"X":51829,"RHEA_ID":53709,"compounds":"(2E)-decenoyl-CoA + NADP(+) => (2E,4Z)-decadienoyl-CoA + H(+) + NADPH"}
{"X":51830,"RHEA_ID":50404,"compounds":"(2-aminobenzoyl)acetate + H(+) + S-octanoyl-L-cysteinyl-[PqsC protein] = 1-(2-aminophenyl)decane-1,3-dione + CO2 + L-cysteinyl-[PqsC protein]"}
{"X":51831,"RHEA_ID":53711,"compounds":"(2E)-decenoyl-CoA + NADP(+) <=> (2E,4Z)-decadienoyl-CoA + H(+) + NADPH"}
{"X":51832,"RHEA_ID":50406,"compounds":"1-(2-aminophenyl)decane-1,3-dione + CO2 + L-cysteinyl-[PqsC protein] => (2-aminobenzoyl)acetate + H(+) + S-octanoyl-L-cysteinyl-[PqsC protein]"}
{"X":51833,"RHEA_ID":57047,"compounds":"D-apionate + NAD(+) <=> 3-oxo-D-isoapionate + H(+) + NADH"}
{"X":51834,"RHEA_ID":50408,"compounds":"1-(2-aminophenyl)decane-1,3-dione = 2-heptyl-4(1H)-quinolone + H2O"}
{"X":51835,"RHEA_ID":60511,"compounds":"a guanosine in mRNA + S-adenosyl-L-methionine <=> an N(7)-methylguanosine in mRNA + S-adenosyl-L-homocysteine"}
{"X":51836,"RHEA_ID":50410,"compounds":"2-heptyl-4(1H)-quinolone + H2O => 1-(2-aminophenyl)decane-1,3-dione"}
{"X":51837,"RHEA_ID":57051,"compounds":"AH2 + ATP + cytidine(32) in tRNA + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] <=> 2-thiocytidine(32) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[cysteine desulfurase]"}
{"X":51838,"RHEA_ID":50412,"DIRECTION":"UN","MASTER_ID":50412,"ec":"2.3.2.29","compounds":"L-leucyl-tRNA(Leu) + N-terminal L-glutamyl-[protein] = H(+) + N-terminal L-leucyl-L-glutamyl-[protein] + tRNA(Leu)"}
{"X":51839,"RHEA_ID":53719,"compounds":"H(+) + N-acetyl-alpha-D-muramate 1-phosphate + UDP <=> phosphate + UDP-N-acetyl-alpha-D-muramate"}
{"X":51840,"RHEA_ID":50414,"compounds":"H(+) + N-terminal L-leucyl-L-glutamyl-[protein] + tRNA(Leu) => L-leucyl-tRNA(Leu) + N-terminal L-glutamyl-[protein]"}
{"X":51841,"RHEA_ID":60517,"compounds":"L-tryptophan => D-tryptophan"}
{"X":51842,"RHEA_ID":57056,"DIRECTION":"UN","MASTER_ID":57056,"ec":"1.1.1.420","compounds":"D-apiofuranose + NAD(+) = D-apionolactone + H(+) + NADH"}
{"X":51843,"RHEA_ID":57057,"compounds":"D-apiofuranose + NAD(+) => D-apionolactone + H(+) + NADH"}
{"X":51844,"RHEA_ID":50418,"compounds":"H(+) + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu) => L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein]"}
{"X":51845,"RHEA_ID":53725,"DIRECTION":"LR","MASTER_ID":53724,"metacyc":"RXN-18662","compounds":"ATP + N-acetyl-D-glucosamine => ADP + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate"}
{"X":51846,"RHEA_ID":50420,"DIRECTION":"UN","MASTER_ID":50420,"ec":"2.3.2.29","compounds":"L-leucyl-tRNA(Leu) + N-terminal L-aspartyl-[protein] = H(+) + N-terminal L-leucyl-L-aspartyl-[protein] + tRNA(Leu)"}
{"X":51847,"RHEA_ID":60523,"compounds":"2 H2O + L-cystine-bis-glycine <=> 2 glycine + L-cystine"}
{"X":51848,"RHEA_ID":50422,"compounds":"H(+) + N-terminal L-leucyl-L-aspartyl-[protein] + tRNA(Leu) => L-leucyl-tRNA(Leu) + N-terminal L-aspartyl-[protein]"}
{"X":51849,"RHEA_ID":53729,"DIRECTION":"LR","MASTER_ID":53728,"metacyc":"RXN-18659","compounds":"H2O + N-acetyl-D-muramate 6-phosphate => N-acetyl-D-muramate + phosphate"}
{"X":51850,"RHEA_ID":50424,"compounds":"(8Z,11Z,14Z)-eicosatrienoate + 2 O2 = prostaglandin G1"}
{"X":51851,"RHEA_ID":57065,"compounds":"D-apionolactone + H2O => D-apionate + H(+)"}
{"X":51852,"RHEA_ID":51520,"DIRECTION":"UN","MASTER_ID":51520,"ec":"2.1.1.337","compounds":"(S)-reticuline + S-adenosyl-L-methionine = (S)-tembetarine + H(+) + S-adenosyl-L-homocysteine"}
{"X":51853,"RHEA_ID":53733,"compounds":"(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminosalicylate => 2-hydroxy-7,8-dihydropteroate + diphosphate"}
{"X":51854,"RHEA_ID":50428,"DIRECTION":"UN","MASTER_ID":50428,"ec":"2.1.1.334","compounds":"methanethiol + S-adenosyl-L-methionine = dimethyl sulfide + H(+) + S-adenosyl-L-homocysteine"}
{"X":51855,"RHEA_ID":53735,"compounds":"(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminosalicylate <=> 2-hydroxy-7,8-dihydropteroate + diphosphate"}
{"X":51856,"RHEA_ID":50430,"compounds":"dimethyl sulfide + H(+) + S-adenosyl-L-homocysteine => methanethiol + S-adenosyl-L-methionine"}
{"X":51857,"RHEA_ID":53737,"DIRECTION":"LR","MASTER_ID":53736,"metacyc":"RXN-13706","compounds":"a 2-halobenzoate + H(+) + NADH + O2 => a halide anion + catechol + CO2 + NAD(+)"}
{"X":51858,"RHEA_ID":58182,"compounds":"all-trans-lycopaoctaene + diphosphate + NADP(+) => (1R,2R,3R)-prephytoene diphosphate + H(+) + NADPH"}
{"X":51859,"RHEA_ID":53739,"compounds":"a 2-halobenzoate + H(+) + NADH + O2 <=> a halide anion + catechol + CO2 + NAD(+)"}
{"X":51860,"RHEA_ID":50434,"compounds":"A + H2O + prostaglandin H1 => AH2 + prostaglandin G1"}
{"X":51861,"RHEA_ID":51529,"compounds":"4-hydroxy-3-methoxybenzoate + H(+) => CO2 + guaiacol"}
{"X":51862,"RHEA_ID":50436,"compounds":"prostaglandin H1 = prostaglandin E1"}
{"X":51863,"RHEA_ID":53743,"compounds":"[Rab1 protein]-O(4)-(5'-adenylyl)-L-tyrosine + H2O <=> [Rab1 protein]-L-tyrosine + AMP + H(+)"}
{"X":51864,"RHEA_ID":50438,"compounds":"prostaglandin E1 => prostaglandin H1"}
{"X":51865,"RHEA_ID":60569,"compounds":"N-acetyl-L-tryptophan => N-acetyl-D-tryptophan"}
{"X":51866,"RHEA_ID":50440,"compounds":"prostaglandin H1 = prostaglandin D1"}
{"X":51867,"RHEA_ID":53747,"compounds":"glycyl-tRNA(Ala) + H2O <=> glycine + H(+) + tRNA(Ala)"}
{"X":51868,"RHEA_ID":50442,"compounds":"prostaglandin D1 => prostaglandin H1"}
{"X":51869,"RHEA_ID":60577,"DIRECTION":"LR","MASTER_ID":60576,"metacyc":"RXN-8133","compounds":"[methyl-Co(III) tetramethylammonium-specific corrinoid protein] + coenzyme M => [Co(I) tetramethylammonium-specific corrinoid protein] + H(+) + methyl-coenzyme M"}
{"X":51870,"RHEA_ID":50444,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 O2 = prostaglandin G3"}
{"X":51871,"RHEA_ID":53751,"compounds":"a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose <=> a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP"}
{"X":51872,"RHEA_ID":50446,"compounds":"prostaglandin G3 => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 O2"}
{"X":51873,"RHEA_ID":53753,"compounds":"a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-glucose => a 1,2-diacyl-3-O-[beta-D-glucopyranosyl-(1->6)-beta-D-galactopyranosyl]-sn-glycerol + H(+) + UDP"}
{"X":51874,"RHEA_ID":50448,"compounds":"AH2 + prostaglandin G3 = A + H2O + prostaglandin H3"}
{"X":51875,"RHEA_ID":53755,"compounds":"a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-glucose <=> a 1,2-diacyl-3-O-[beta-D-glucopyranosyl-(1->6)-beta-D-galactopyranosyl]-sn-glycerol + H(+) + UDP"}
{"X":51876,"RHEA_ID":50450,"compounds":"A + H2O + prostaglandin H3 => AH2 + prostaglandin G3"}
{"X":51877,"RHEA_ID":60605,"compounds":"1-tetradecanoyl-sn-glycero-3-phosphocholine => 1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + choline"}
{"X":51878,"RHEA_ID":50452,"compounds":"prostaglandin H3 = prostaglandin E3"}
{"X":51879,"RHEA_ID":50453,"compounds":"prostaglandin H3 => prostaglandin E3"}
{"X":51880,"RHEA_ID":50454,"compounds":"prostaglandin E3 => prostaglandin H3"}
{"X":51881,"RHEA_ID":60609,"compounds":"1-tetradecanoyl-sn-glycero-3-phosphoethanolamine => 1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + ethanolamine"}
{"X":51882,"RHEA_ID":50456,"compounds":"prostaglandin H3 = prostaglandin D3"}
{"X":51883,"RHEA_ID":60610,"compounds":"1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + ethanolamine => 1-tetradecanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":51884,"RHEA_ID":50458,"compounds":"prostaglandin D3 => prostaglandin H3"}
{"X":51885,"RHEA_ID":50459,"compounds":"prostaglandin H3 <=> prostaglandin D3"}
{"X":51886,"RHEA_ID":53766,"compounds":"allocholoyl-CoA + lithocholate => allocholate + lithocholoyl-CoA"}
{"X":51887,"RHEA_ID":53767,"compounds":"allocholate + lithocholoyl-CoA <=> allocholoyl-CoA + lithocholate"}
{"X":51888,"RHEA_ID":50462,"compounds":"a medium-chain fatty acyl-[ACP] + AMP + diphosphate => a medium chain fatty acid + ATP + holo-[ACP]"}
{"X":51889,"RHEA_ID":50463,"compounds":"a medium chain fatty acid + ATP + holo-[ACP] <=> a medium-chain fatty acyl-[ACP] + AMP + diphosphate"}
{"X":51890,"RHEA_ID":50464,"DIRECTION":"UN","MASTER_ID":50464,"ec":"2.3.1.261","compounds":"4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 24 H(+) + 8 malonyl-CoA + 16 NADPH = 17-(4-hydroxyphenyl)heptadecanoyl-[4-hydroxyphenylalkanoate synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+)"}
{"X":51891,"RHEA_ID":53771,"compounds":"allocholate + allodeoxycholoyl-CoA <=> allocholoyl-CoA + allodeoxycholate"}
{"X":51892,"RHEA_ID":50466,"compounds":"17-(4-hydroxyphenyl)heptadecanoyl-[4-hydroxyphenylalkanoate synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+) => 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 24 H(+) + 8 malonyl-CoA + 16 NADPH"}
{"X":51893,"RHEA_ID":60621,"compounds":"N-hexanoyl-sphing-4-enine-1-phosphocholine => choline + N-(hexanoyl)-sphing-4-enine-1,3-cyclic phosphate"}
{"X":51894,"RHEA_ID":53775,"compounds":"chenodeoxycholate + lithocholoyl-CoA <=> chenodeoxycholoyl-CoA + lithocholate"}
{"X":51895,"RHEA_ID":60624,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 H2O = 2 (9Z)-octadecenoate + 2 H(+) + sn-glycero-3-phosphoethanolamine"}
{"X":51896,"RHEA_ID":60625,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 H2O => 2 (9Z)-octadecenoate + 2 H(+) + sn-glycero-3-phosphoethanolamine"}
{"X":51897,"RHEA_ID":60626,"compounds":"2 (9Z)-octadecenoate + 2 H(+) + sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 H2O"}
{"X":51898,"RHEA_ID":60627,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 H2O <=> 2 (9Z)-octadecenoate + 2 H(+) + sn-glycero-3-phosphoethanolamine"}
{"X":51899,"RHEA_ID":50474,"compounds":"(2-aminobenzoyl)acetyl-CoA + CO2 + CoA => anthraniloyl-CoA + H(+) + malonyl-CoA"}
{"X":51900,"RHEA_ID":60629,"DIRECTION":"LR","MASTER_ID":60628,"metacyc":"RXNQT-4343","compounds":"AH2 + gluconapin + O2 => A + H2O + xi-progoitrin"}
{"X":51901,"RHEA_ID":60630,"compounds":"A + H2O + xi-progoitrin => AH2 + gluconapin + O2"}
{"X":51902,"RHEA_ID":53783,"compounds":"beta-muricholate + lithocholoyl-CoA <=> beta-muricholoyl-CoA + lithocholate"}
{"X":51903,"RHEA_ID":50478,"compounds":"CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein] => anthraniloyl-CoA + L-cysteinyl-[PqsD protein]"}
{"X":51904,"RHEA_ID":60633,"compounds":"all-trans-4-oxoretinol + NAD(+) => all-trans-4-oxoretinal + H(+) + NADH"}
{"X":51905,"RHEA_ID":60634,"compounds":"all-trans-4-oxoretinal + H(+) + NADH => all-trans-4-oxoretinol + NAD(+)"}
{"X":51906,"RHEA_ID":60635,"compounds":"all-trans-4-oxoretinol + NAD(+) <=> all-trans-4-oxoretinal + H(+) + NADH"}
{"X":51907,"RHEA_ID":50482,"compounds":"CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-aspartyl-[protein]"}
{"X":51908,"RHEA_ID":50483,"compounds":"acetyl-CoA + N-terminal L-methionyl-L-aspartyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein]"}
{"X":51909,"RHEA_ID":60638,"compounds":"choline + N-dodecanoyl-sphing-4-enine-1,3-cyclic phosphate => N-(dodecanoyl)-sphing-4-enine-1-phosphocholine"}
{"X":51910,"RHEA_ID":53791,"compounds":"allodeoxycholoyl-CoA + beta-muricholate <=> allodeoxycholate + beta-muricholoyl-CoA"}
{"X":51911,"RHEA_ID":50486,"compounds":"CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-asparaginyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-asparaginyl-[protein]"}
{"X":51912,"RHEA_ID":60645,"DIRECTION":"LR","MASTER_ID":60644,"metacyc":"RXN-20216","compounds":"3'-phosphoadenylyl sulfate + 3alpha-hydroxy-5alpha-androstan-17-one => 3alpha-sulfooxy-5alpha-androstan-17-one + adenosine 3',5'-bisphosphate + H(+)"}
{"X":51913,"RHEA_ID":57127,"compounds":"2-oxoglutaramate <=> 2-hydroxy-5-oxoproline"}
{"X":51914,"RHEA_ID":53795,"compounds":"O2 + phenylmethanethiol <=> benzothialdehyde + H2O2"}
{"X":51915,"RHEA_ID":60648,"compounds":"an N-(acyl)-sphingosylphosphoethanolamine = an N-(acyl)-sphingosyl-1,3-cyclic phosphate + ethanolamine"}
{"X":51916,"RHEA_ID":50491,"compounds":"acetyl-CoA + N-terminal L-methionyl-L-glutamyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein]"}
{"X":51917,"RHEA_ID":53798,"compounds":"deoxycholate + ursodeoxycholoyl-CoA => deoxycholoyl-CoA + ursodeoxycholate"}
{"X":51918,"RHEA_ID":60650,"compounds":"an N-(acyl)-sphingosyl-1,3-cyclic phosphate + ethanolamine => an N-(acyl)-sphingosylphosphoethanolamine"}
{"X":51919,"RHEA_ID":50494,"compounds":"CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutaminyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-glutaminyl-[protein]"}
{"X":51920,"RHEA_ID":50495,"compounds":"acetyl-CoA + N-terminal L-methionyl-L-glutaminyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutaminyl-[protein]"}
{"X":51921,"RHEA_ID":53802,"compounds":"lithocholate + ursodeoxycholoyl-CoA => lithocholoyl-CoA + ursodeoxycholate"}
{"X":51922,"RHEA_ID":53803,"compounds":"lithocholoyl-CoA + ursodeoxycholate <=> lithocholate + ursodeoxycholoyl-CoA"}
{"X":51923,"RHEA_ID":50498,"compounds":"CoA + H(+) + N-terminal N(alpha)-acetylglycyl-[protein] => acetyl-CoA + N-terminal glycyl-[protein]"}
{"X":51924,"RHEA_ID":50499,"compounds":"acetyl-CoA + N-terminal glycyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetylglycyl-[protein]"}
{"X":51925,"RHEA_ID":60658,"compounds":"1-hexadecanoyl-sn-glycero-2,3-cyclic phosphate + choline => 1-hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":51926,"RHEA_ID":53807,"compounds":"allodeoxycholoyl-CoA + ursodeoxycholate <=> allodeoxycholate + ursodeoxycholoyl-CoA"}
{"X":51927,"RHEA_ID":50502,"compounds":"CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[protein] => acetyl-CoA + N-terminal L-alanyl-[protein]"}
{"X":51928,"RHEA_ID":50503,"compounds":"acetyl-CoA + N-terminal L-alanyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[protein]"}
{"X":51929,"RHEA_ID":57143,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine <=> 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine"}
{"X":51930,"RHEA_ID":53811,"compounds":"cholestanol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S)-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":51931,"RHEA_ID":60664,"compounds":"H2O + NADPH = NADH + phosphate"}
{"X":51932,"RHEA_ID":50507,"compounds":"acetyl-CoA + N-terminal L-seryl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[protein]"}
{"X":51933,"RHEA_ID":60666,"compounds":"NADH + phosphate => H2O + NADPH"}
{"X":51934,"RHEA_ID":58259,"compounds":"H2O + O-(ADP-D-ribosyl)-L-seryl-[protein] <=> ADP-D-ribose + L-seryl-[protein]"}
{"X":51935,"RHEA_ID":60668,"compounds":"(R,R)-chrysanthemol + NAD(+) = (1R,3R)-chrysanthemal + H(+) + NADH"}
{"X":51936,"RHEA_ID":50511,"compounds":"acetyl-CoA + N-terminal L-valyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-valyl-[protein]"}
{"X":51937,"RHEA_ID":53818,"compounds":"L-cysteine + succinate => hydrogen sulfide + O-succinyl-L-serine"}
{"X":51938,"RHEA_ID":58263,"compounds":"H2O + O-(ADP-D-ribosyl)-L-tyrosyl-[protein] <=> ADP-D-ribose + L-tyrosyl-[protein]"}
{"X":51939,"RHEA_ID":60672,"compounds":"NAD(+) + nerol = H(+) + NADH + neral"}
{"X":51940,"RHEA_ID":50515,"compounds":"acetyl-CoA + N-terminal L-cysteinyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-cysteinyl-[protein]"}
{"X":51941,"RHEA_ID":53822,"compounds":"7-oxolithocholate + H(+) + NADPH => chenodeoxycholate + NADP(+)"}
{"X":51942,"RHEA_ID":53823,"compounds":"chenodeoxycholate + NADP(+) <=> 7-oxolithocholate + H(+) + NADPH"}
{"X":51943,"RHEA_ID":50518,"compounds":"CoA + H(+) + N-terminal N(alpha)-acetyl-L-threonyl-[protein] => acetyl-CoA + N-terminal L-threonyl-[protein]"}
{"X":51944,"RHEA_ID":50519,"compounds":"acetyl-CoA + N-terminal L-threonyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-threonyl-[protein]"}
{"X":51945,"RHEA_ID":60678,"compounds":"(S)-(-)-citronellal + H(+) + NADH => (S)-(-)-citronellol + NAD(+)"}
{"X":51946,"RHEA_ID":51615,"DIRECTION":"BI","MASTER_ID":51612,"metacyc":"RXN-18433","compounds":"(R)-2-hydroxyglutarate + oxaloacetate <=> (R)-malate + 2-oxoglutarate"}
{"X":51947,"RHEA_ID":50521,"DIRECTION":"LR","MASTER_ID":50520,"metacyc":"RXN-17854","compounds":"acetyl-CoA + N-terminal L-methionyl-L-leucyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein]"}
{"X":51948,"RHEA_ID":50522,"compounds":"CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-leucyl-[protein]"}
{"X":51949,"RHEA_ID":57163,"compounds":"2-oxoglutarate + L-arginyl-[ribosomal protein eS6] + O2 <=> (3R)-3-hydroxy-L-arginyl-[ribosomal protein eS6] + CO2 + succinate"}
{"X":51950,"RHEA_ID":54937,"compounds":"(2E)-decenoyl-[ACP] + H(+) + NADH => decanoyl-[ACP] + NAD(+)"}
{"X":51951,"RHEA_ID":50525,"DIRECTION":"LR","MASTER_ID":50524,"metacyc":"RXN-17855","compounds":"acetyl-CoA + N-terminal L-methionyl-L-isoleucyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-isoleucyl-[protein]"}
{"X":51952,"RHEA_ID":50526,"compounds":"CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-isoleucyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-isoleucyl-[protein]"}
{"X":51953,"RHEA_ID":57167,"compounds":"2-oxoglutarate + L-arginyl-[RCC1 domain-containing protein] + O2 <=> (3R)-3-hydroxy-L-arginyl-[RCC1 domain-containing protein] + CO2 + succinate"}
{"X":51954,"RHEA_ID":60686,"compounds":"(11R)-dihydroartemisinate + 2 H(+) + NADPH => (11R)-dihydroartemisinic aldehyde + H2O + NADP(+)"}
{"X":51955,"RHEA_ID":50528,"DIRECTION":"UN","MASTER_ID":50528,"ec":"2.3.1.258","compounds":"acetyl-CoA + N-terminal L-methionyl-L-phenylalanyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein]"}
{"X":51956,"RHEA_ID":50529,"DIRECTION":"LR","MASTER_ID":50528,"metacyc":"RXN-17856","compounds":"acetyl-CoA + N-terminal L-methionyl-L-phenylalanyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein]"}
{"X":51957,"RHEA_ID":57171,"compounds":"(R)-2-hydroxyglutarate + FAD + H(+) <=> 2-oxoglutarate + FADH2"}
{"X":51958,"RHEA_ID":53839,"compounds":"a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-acyl-alpha-D-glucosamine <=> a UDP-2-N,3-O-bis((3R)-3-hydroxyacyl)-alpha-D-glucosamine + H(+) + holo-[ACP]"}
{"X":51959,"RHEA_ID":50532,"DIRECTION":"UN","MASTER_ID":50532,"ec":"2.3.1.258","compounds":"acetyl-CoA + N-terminal L-methionyl-L-tyrosyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein]"}
{"X":51960,"RHEA_ID":60693,"compounds":"(E)-non-2-enal + H2O + NADP(+) => (E)-non-2-enoate + 2 H(+) + NADPH"}
{"X":51961,"RHEA_ID":53846,"compounds":"7-oxo-glycolithocholate + H(+) + NADH => glycochenodeoxycholate + NAD(+)"}
{"X":51962,"RHEA_ID":54949,"compounds":"(3R)-hydroxy-(5Z)-dodecenoyl-[ACP] => (2E,5Z)-dodecadienoyl-[ACP] + H2O"}
{"X":51963,"RHEA_ID":50535,"compounds":"acetyl-CoA + N-terminal L-methionyl-L-tyrosyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein]"}
{"X":51964,"RHEA_ID":50536,"compounds":"prostaglandin E2 = H2O + prostaglandin A2"}
{"X":51965,"RHEA_ID":53850,"compounds":"7-oxo-taurodeoxycholate + H(+) + NADH => NAD(+) + taurocholate"}
{"X":51966,"RHEA_ID":53851,"compounds":"NAD(+) + taurocholate <=> 7-oxo-taurodeoxycholate + H(+) + NADH"}
{"X":51967,"RHEA_ID":50539,"compounds":"prostaglandin E2 <=> H2O + prostaglandin A2"}
{"X":51968,"RHEA_ID":60701,"compounds":"a 1-acyl-sn-glycero-3-phosphocholine => a 1-acyl-sn-glycero-2,3-cyclic phosphate + choline"}
{"X":51969,"RHEA_ID":50541,"DIRECTION":"LR","MASTER_ID":50540,"reactome":"R-HSA-2161666.2","compounds":"prostaglandin A2 => prostaglandin C2"}
{"X":51970,"RHEA_ID":53855,"compounds":"glycocholate + NAD(+) <=> 7-oxo-glycodeoxycholate + H(+) + NADH"}
{"X":51971,"RHEA_ID":50543,"compounds":"prostaglandin A2 <=> prostaglandin C2"}
{"X":51972,"RHEA_ID":60705,"compounds":"a 1-acyl-sn-glycero-3-phosphoethanolamine => a 1-acyl-sn-glycero-2,3-cyclic phosphate + ethanolamine"}
{"X":51973,"RHEA_ID":53858,"compounds":"3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH => NADP(+) + ursocholate"}
{"X":51974,"RHEA_ID":60707,"compounds":"a 1-acyl-sn-glycero-3-phosphoethanolamine <=> a 1-acyl-sn-glycero-2,3-cyclic phosphate + ethanolamine"}
{"X":51975,"RHEA_ID":50547,"compounds":"prostaglandin C2 <=> prostaglandin B2"}
{"X":51976,"RHEA_ID":60709,"compounds":"(1R,3R)-chrysanthemal + H2O + NAD(+) => (1R,3R)-chrysanthemate + 2 H(+) + NADH"}
{"X":51977,"RHEA_ID":57191,"compounds":"H2O + N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein] <=> glycolate + H(+) + L-arginyl-[protein]"}
{"X":51978,"RHEA_ID":60710,"compounds":"(1R,3R)-chrysanthemate + 2 H(+) + NADH => (1R,3R)-chrysanthemal + H2O + NAD(+)"}
{"X":51979,"RHEA_ID":50551,"compounds":"prostaglandin E1 <=> H2O + prostaglandin A1"}
{"X":51980,"RHEA_ID":60713,"compounds":"(+)-artemisinic alcohol + NAD(+) => (+)-artemisinic aldehyde + H(+) + NADH"}
{"X":51981,"RHEA_ID":53866,"compounds":"7,12-dioxo-lithocholate + H(+) + NADPH => 3alpha,7beta-dihydroxy-12-oxo-5beta-cholan-24-oate + NADP(+)"}
{"X":51982,"RHEA_ID":53867,"compounds":"3alpha,7beta-dihydroxy-12-oxo-5beta-cholan-24-oate + NADP(+) <=> 7,12-dioxo-lithocholate + H(+) + NADPH"}
{"X":51983,"RHEA_ID":50555,"compounds":"prostaglandin C1 <=> prostaglandin B1"}
{"X":51984,"RHEA_ID":60717,"compounds":"(1R,3R)-chrysanthemal + H2O + NADP(+) => (1R,3R)-chrysanthemate + 2 H(+) + NADPH"}
{"X":51985,"RHEA_ID":53870,"compounds":"1-hydroxyphenazine + CO2 + H2O + NAD(+) => 2 H(+) + NADH + O2 + phenazine-1-carboxylate"}
{"X":51986,"RHEA_ID":51655,"compounds":"D-mannonate + NAD(+) <=> H(+) + keto-D-tagaturonate + NADH"}
{"X":51987,"RHEA_ID":50559,"compounds":"prostaglandin D2 <=> H2O + prostaglandin J2"}
{"X":51988,"RHEA_ID":60721,"compounds":"(E)-hept-2-enal + H2O + NADP(+) => (E)-hept-2-enoate + 2 H(+) + NADPH"}
{"X":51989,"RHEA_ID":50561,"DIRECTION":"LR","MASTER_ID":50560,"metacyc":"RXN-17857","compounds":"acetyl-CoA + N-terminal L-methionyl-L-tryptophyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tryptophyl-[protein]"}
{"X":51990,"RHEA_ID":60722,"compounds":"(E)-hept-2-enoate + 2 H(+) + NADPH => (E)-hept-2-enal + H2O + NADP(+)"}
{"X":51991,"RHEA_ID":50563,"compounds":"acetyl-CoA + N-terminal L-methionyl-L-tryptophyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tryptophyl-[protein]"}
{"X":51992,"RHEA_ID":60725,"compounds":"dodecanal + H2O + NADP(+) => dodecanoate + 2 H(+) + NADPH"}
{"X":51993,"RHEA_ID":53878,"compounds":"ADP + an N(4)-acetylcytidine in tRNA + CoA + H(+) + phosphate => a cytidine in tRNA + acetyl-CoA + ATP + H2O"}
{"X":51994,"RHEA_ID":60726,"compounds":"dodecanoate + 2 H(+) + NADPH => dodecanal + H2O + NADP(+)"}
{"X":51995,"RHEA_ID":50567,"compounds":"acetyl-CoA + N-terminal L-methionyl-L-alanyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-alanyl-[protein]"}
{"X":51996,"RHEA_ID":50568,"DIRECTION":"UN","MASTER_ID":50568,"ec":"2.3.1.258","compounds":"acetyl-CoA + N-terminal L-methionyl-L-seryl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-seryl-[protein]"}
{"X":51997,"RHEA_ID":56122,"compounds":"3-(all-trans-heptaprenyl)benzene-1,2-diol + H2O + NADP(+) => 2-all-trans-heptaprenylphenol + H(+) + NADPH + O2"}
{"X":51998,"RHEA_ID":51667,"compounds":"D-5-phenylhydantoin + H2O <=> H(+) + N-carbamoyl-D-phenylglycine"}
{"X":51999,"RHEA_ID":50571,"compounds":"acetyl-CoA + N-terminal L-methionyl-L-seryl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-seryl-[protein]"}
{"X":52000,"RHEA_ID":50572,"DIRECTION":"UN","MASTER_ID":50572,"ec":"2.3.1.258","compounds":"acetyl-CoA + N-terminal L-methionyl-L-valyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-valyl-[protein]"}
{"X":52001,"RHEA_ID":53886,"compounds":"alpha,alpha-trehalose 6-phosphate + CDP + H(+) => CDP-alpha-D-glucose + D-glucose 6-phosphate"}
{"X":52002,"RHEA_ID":53887,"compounds":"CDP-alpha-D-glucose + D-glucose 6-phosphate <=> alpha,alpha-trehalose 6-phosphate + CDP + H(+)"}
{"X":52003,"RHEA_ID":50575,"compounds":"acetyl-CoA + N-terminal L-methionyl-L-valyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-valyl-[protein]"}
{"X":52004,"RHEA_ID":50576,"DIRECTION":"UN","MASTER_ID":50576,"ec":"2.3.1.258","compounds":"acetyl-CoA + N-terminal L-methionyl-L-threonyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-threonyl-[protein]"}
{"X":52005,"RHEA_ID":50577,"DIRECTION":"LR","MASTER_ID":50576,"metacyc":"RXN-17871","compounds":"acetyl-CoA + N-terminal L-methionyl-L-threonyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-threonyl-[protein]"}
{"X":52006,"RHEA_ID":53891,"compounds":"D-glucose 6-phosphate + TDP-alpha-D-glucose <=> alpha,alpha-trehalose 6-phosphate + H(+) + TDP"}
{"X":52007,"RHEA_ID":50579,"compounds":"acetyl-CoA + N-terminal L-methionyl-L-threonyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-threonyl-[protein]"}
{"X":52008,"RHEA_ID":50580,"DIRECTION":"UN","MASTER_ID":50580,"ec":"2.3.1.258","compounds":"acetyl-CoA + N-terminal L-methionyl-L-lysyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-lysyl-[protein]"}
{"X":52009,"RHEA_ID":53894,"compounds":"a prenal + H2O2 + L-cysteine => an S-prenyl-L-cysteine + H2O + O2"}
{"X":52010,"RHEA_ID":50583,"compounds":"acetyl-CoA + N-terminal L-methionyl-L-lysyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-lysyl-[protein]"}
{"X":52011,"RHEA_ID":50584,"compounds":"13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) = 15-oxo-prostaglandin E1 + H(+) + NADPH"}
{"X":52012,"RHEA_ID":50585,"compounds":"13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) => 15-oxo-prostaglandin E1 + H(+) + NADPH"}
{"X":52013,"RHEA_ID":57228,"compounds":"GDP + glyoxal = N(2)-(1-hydroxy-2-oxoethyl)-GDP"}
{"X":52014,"RHEA_ID":60748,"compounds":"(1R,3R)-pyrethroyl-CoA + (Z,S)-pyrethrolone = CoA + pyrethrin II"}
{"X":52015,"RHEA_ID":50588,"compounds":"13,14-dihydro-15-oxo-PGF2alpha + NADP(+) = 15-oxo-prostaglandin F2alpha + H(+) + NADPH"}
{"X":52016,"RHEA_ID":50589,"compounds":"13,14-dihydro-15-oxo-PGF2alpha + NADP(+) => 15-oxo-prostaglandin F2alpha + H(+) + NADPH"}
{"X":52017,"RHEA_ID":57232,"compounds":"GDP + methylglyoxal = N(2)-(1-hydroxy-2-oxopropyl)-GDP"}
{"X":52018,"RHEA_ID":60752,"compounds":"(1R,3R)-chrysanthemoyl-CoA + (Z,S)-jasmololone = CoA + jasmolin I"}
{"X":52019,"RHEA_ID":50592,"compounds":"13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) = 15-oxoprostaglandin F1alpha + H(+) + NADPH"}
{"X":52020,"RHEA_ID":50593,"compounds":"13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) => 15-oxoprostaglandin F1alpha + H(+) + NADPH"}
{"X":52021,"RHEA_ID":57236,"compounds":"GMP + methylglyoxal = N(2)-(1-hydroxy-2-oxopropyl)-GMP"}
{"X":52022,"RHEA_ID":50595,"compounds":"13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) <=> 15-oxoprostaglandin F1alpha + H(+) + NADPH"}
{"X":52023,"RHEA_ID":50596,"DIRECTION":"UN","MASTER_ID":50596,"ec":"2.3.1.257","compounds":"acetyl-CoA + N-terminal L-seryl-[histone H4] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H4]"}
{"X":52024,"RHEA_ID":50597,"compounds":"acetyl-CoA + N-terminal L-seryl-[histone H4] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H4]"}
{"X":52025,"RHEA_ID":57240,"compounds":"glyoxal + GMP = N(2)-(1-hydroxy-2-oxoethyl)-GMP"}
{"X":52026,"RHEA_ID":50599,"DIRECTION":"BI","MASTER_ID":50596,"metacyc":"RXN-17866","compounds":"acetyl-CoA + N-terminal L-seryl-[histone H4] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H4]"}
{"X":52027,"RHEA_ID":50600,"DIRECTION":"UN","MASTER_ID":50600,"ec":"2.3.1.257","compounds":"acetyl-CoA + N-terminal L-seryl-[histone H2A] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H2A]"}
{"X":52028,"RHEA_ID":50601,"DIRECTION":"LR","MASTER_ID":50600,"metacyc":"RXN-17865","compounds":"acetyl-CoA + N-terminal L-seryl-[histone H2A] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H2A]"}
{"X":52029,"RHEA_ID":57244,"compounds":"H2O + N(2)-(1-hydroxy-2-oxopropyl)-dGTP = dGTP + H(+) + lactate"}
{"X":52030,"RHEA_ID":60764,"compounds":"(1R,3R)-pyrethroyl-CoA + (Z,S)-cinerolone = cinerin II + CoA"}
{"X":52031,"RHEA_ID":50604,"DIRECTION":"UN","MASTER_ID":50604,"ec":"2.3.1.259","compounds":"acetyl-CoA + N-terminal L-methionyl-[transmembrane protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein]"}
{"X":52032,"RHEA_ID":50605,"DIRECTION":"LR","MASTER_ID":50604,"metacyc":"RXN-17872","compounds":"acetyl-CoA + N-terminal L-methionyl-[transmembrane protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein]"}
{"X":52033,"RHEA_ID":53919,"compounds":"an acyl-CoA + L-lysyl-[protein] <=> CoA + H(+) + N(6)-acyl-L-lysyl-[protein]"}
{"X":52034,"RHEA_ID":60776,"compounds":"2-oxoglutarate + gibberellin A12 + O2 = CO2 + gibberellin A15 + succinate"}
{"X":52035,"RHEA_ID":50608,"compounds":"leukotriene B4 + NADP(+) = 12-oxo-leukotriene B4 + H(+) + NADPH"}
{"X":52036,"RHEA_ID":53922,"compounds":"[Fas-activated protein]-O-phospho-L-threonine + ADP + H(+) => [Fas-activated protein]-L-threonine + ATP"}
{"X":52037,"RHEA_ID":53923,"DIRECTION":"BI","MASTER_ID":53920,"metacyc":"2.7.11.8-RXN","compounds":"[Fas-activated protein]-L-threonine + ATP <=> [Fas-activated protein]-O-phospho-L-threonine + ADP + H(+)"}
{"X":52038,"RHEA_ID":60780,"compounds":"2-oxoglutarate + gibberellin A15 + O2 = CO2 + gibberellin A24 + H2O + succinate"}
{"X":52039,"RHEA_ID":50612,"compounds":"decanal + NADP(+) = (2E)-dec-2-enal + H(+) + NADPH"}
{"X":52040,"RHEA_ID":60781,"DIRECTION":"LR","MASTER_ID":60780,"metacyc":"RXN1F-163","compounds":"2-oxoglutarate + gibberellin A15 + O2 => CO2 + gibberellin A24 + H2O + succinate"}
{"X":52041,"RHEA_ID":53927,"compounds":"a secondary amine + S-adenosyl-L-methionine <=> a methylated secondary amine + H(+) + S-adenosyl-L-homocysteine"}
{"X":52042,"RHEA_ID":60784,"compounds":"2-oxoglutarate + gibberellin A24 + O2 = CO2 + gibberellin A25 + H(+) + succinate"}
{"X":52043,"RHEA_ID":51713,"compounds":"keto-D-tagatose 6-phosphate => keto-D-fructose 6-phosphate"}
{"X":52044,"RHEA_ID":50617,"compounds":"NADP(+) + nonan-2-one => (3E)-3-nonen-2-one + H(+) + NADPH"}
{"X":52045,"RHEA_ID":57260,"compounds":"H2O + N(2)-(1-hydroxy-2-oxopropyl)-GDP = GDP + H(+) + lactate"}
{"X":52046,"RHEA_ID":60800,"compounds":"2-oxoglutarate + gibberellin A53 + O2 = CO2 + gibberellin A44 + succinate"}
{"X":52047,"RHEA_ID":51717,"compounds":"ATP(in) + CoA(in) + H(+)(out) + hexadecanoate(out) => AMP(in) + diphosphate(in) + H(+)(in) + hexadecanoyl-CoA(in)"}
{"X":52048,"RHEA_ID":50621,"compounds":"N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + UDP-alpha-D-galactose => alpha-D-Gal-(1->3)-alpha-D-GlcNAc-diphospho-di-trans,octa-cis-undecaprenol + H(+) + UDP"}
{"X":52049,"RHEA_ID":53935,"compounds":"O2 + prostaglandin I2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxy-prostaglandin I2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52050,"RHEA_ID":60804,"compounds":"2-oxoglutarate + gibberellin A19 + O2 = CO2 + gibberellin A17 + H(+) + succinate"}
{"X":52051,"RHEA_ID":50624,"DIRECTION":"UN","MASTER_ID":50624,"ec":"2.3.3.17","compounds":"acetyl-CoA + an omega-(methylsulfanyl)-2-oxoalkanoate + H2O = a 2-(omega-methylsulfanyl)alkylmalate + CoA + H(+)"}
{"X":52052,"RHEA_ID":50625,"compounds":"acetyl-CoA + an omega-(methylsulfanyl)-2-oxoalkanoate + H2O => a 2-(omega-methylsulfanyl)alkylmalate + CoA + H(+)"}
{"X":52053,"RHEA_ID":60807,"compounds":"2-oxoglutarate + gibberellin A19 + O2 <=> CO2 + gibberellin A17 + H(+) + succinate"}
{"X":52054,"RHEA_ID":53940,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2 = 18-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52055,"RHEA_ID":51725,"DIRECTION":"LR","MASTER_ID":51724,"reactome":"R-HSA-6810472.1","compounds":"H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate => adenosine 5'-tetraphosphate + ADP + 2 H(+)"}
{"X":52056,"RHEA_ID":60822,"compounds":"adenosine 3',5'-bisphosphate + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide => H2O + NADPH"}
{"X":52057,"RHEA_ID":50630,"compounds":"a 3-(omega-methylsulfanyl)alkylmalate => a 2-(omega-methylsulfanyl)alkylmalate"}
{"X":52058,"RHEA_ID":60824,"compounds":"H2O + P(1),P(2)-bis(5'-adenosyl) diphosphate = 2 AMP + 2 H(+)"}
{"X":52059,"RHEA_ID":50632,"DIRECTION":"UN","MASTER_ID":50632,"ec":"4.2.1.170","compounds":"a 2-(omega-methylsulfanyl)alkylmalate = a 2-(omega-methylsulfanyl)alkylmaleate + H2O"}
{"X":52060,"RHEA_ID":50633,"compounds":"a 2-(omega-methylsulfanyl)alkylmalate => a 2-(omega-methylsulfanyl)alkylmaleate + H2O"}
{"X":52061,"RHEA_ID":50634,"compounds":"a 2-(omega-methylsulfanyl)alkylmaleate + H2O => a 2-(omega-methylsulfanyl)alkylmalate"}
{"X":52062,"RHEA_ID":60827,"compounds":"H2O + P(1),P(2)-bis(5'-adenosyl) diphosphate <=> 2 AMP + 2 H(+)"}
{"X":52063,"RHEA_ID":60829,"compounds":"a 5'-end triphospho-adenosine in mRNA + H2O => a 5'-end diphospho-adenosine in mRNA + H(+) + phosphate"}
{"X":52064,"RHEA_ID":50637,"compounds":"a 3-(omega-methylsulfanyl)alkylmalate => a 2-(omega-methylsulfanyl)alkylmaleate + H2O"}
{"X":52065,"RHEA_ID":50638,"compounds":"a 2-(omega-methylsulfanyl)alkylmaleate + H2O => a 3-(omega-methylsulfanyl)alkylmalate"}
{"X":52066,"RHEA_ID":60831,"compounds":"a 5'-end triphospho-adenosine in mRNA + H2O <=> a 5'-end diphospho-adenosine in mRNA + H(+) + phosphate"}
{"X":52067,"RHEA_ID":50640,"compounds":"2-(2-methylsulfanyl)ethylmalate = 3-(2-methylsulfanyl)ethylmalate"}
{"X":52068,"RHEA_ID":60834,"compounds":"a 5'-end diphospho-guanosine in mRNA + H(+) + phosphate => a 5'-end triphospho-guanosine in mRNA + H2O"}
{"X":52069,"RHEA_ID":55057,"DIRECTION":"LR","MASTER_ID":55056,"metacyc":"RXN-18490","compounds":"a 12-hydroxyjasmonyl-L-alpha-amino acid + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":52070,"RHEA_ID":51740,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A = a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate)"}
{"X":52071,"RHEA_ID":50644,"compounds":"2-(3-methylsulfanyl)propylmalate = 3-(3-methylsulfanyl)propylmalate"}
{"X":52072,"RHEA_ID":50645,"DIRECTION":"LR","MASTER_ID":50644,"metacyc":"RXNQT-4164","compounds":"2-(3-methylsulfanyl)propylmalate => 3-(3-methylsulfanyl)propylmalate"}
{"X":52073,"RHEA_ID":60839,"compounds":"a 5'-end diphospho-adenosine in mRNA + GTP + H(+) <=> a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + diphosphate"}
{"X":52074,"RHEA_ID":50648,"DIRECTION":"UN","MASTER_ID":50648,"ec":"4.2.1.170","compounds":"2-(2-methylsulfanyl)ethylmalate = 2-(2-methylsulfanyl)ethylmaleate + H2O"}
{"X":52075,"RHEA_ID":50649,"compounds":"2-(2-methylsulfanyl)ethylmalate => 2-(2-methylsulfanyl)ethylmaleate + H2O"}
{"X":52076,"RHEA_ID":60843,"compounds":"a 5'-end diphospho-adenosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] <=> a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + L-lysyl-[protein]"}
{"X":52077,"RHEA_ID":51748,"compounds":"4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A = 4-amino-4-deoxy-beta-L-arabinopyranosyl-lipid A + di-trans,octa-cis-undecaprenyl phosphate"}
{"X":52078,"RHEA_ID":50652,"DIRECTION":"UN","MASTER_ID":50652,"ec":"4.2.1.170","compounds":"2-(3-methylsulfanyl)propylmalate = 2-(2-methylsulfanyl)propylmaleate + H2O"}
{"X":52079,"RHEA_ID":50653,"compounds":"2-(3-methylsulfanyl)propylmalate => 2-(2-methylsulfanyl)propylmaleate + H2O"}
{"X":52080,"RHEA_ID":57296,"compounds":"an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA + H2O = a 2'-deoxyguanosine in DNA + glycolate + H(+)"}
{"X":52081,"RHEA_ID":50655,"DIRECTION":"BI","MASTER_ID":50652,"metacyc":"RXN-18184","compounds":"2-(3-methylsulfanyl)propylmalate <=> 2-(2-methylsulfanyl)propylmaleate + H2O"}
{"X":52082,"RHEA_ID":50656,"DIRECTION":"UN","MASTER_ID":50656,"ec":"4.2.1.170","compounds":"3-(2-methylsulfanyl)ethylmalate = 2-(2-methylsulfanyl)ethylmaleate + H2O"}
{"X":52083,"RHEA_ID":50657,"compounds":"3-(2-methylsulfanyl)ethylmalate => 2-(2-methylsulfanyl)ethylmaleate + H2O"}
{"X":52084,"RHEA_ID":53971,"compounds":"apo-[BtrI ACP] + CoA <=> adenosine 3',5'-bisphosphate + H(+) + holo-[BtrI ACP]"}
{"X":52085,"RHEA_ID":62117,"DIRECTION":"LR","MASTER_ID":62116,"metacyc":"RXN-9771","compounds":"H2O + iminosuccinate => NH4(+) + oxaloacetate"}
{"X":52086,"RHEA_ID":50660,"DIRECTION":"UN","MASTER_ID":50660,"ec":"4.2.1.170","compounds":"3-(3-methylsulfanyl)propylmalate = 2-(2-methylsulfanyl)propylmaleate + H2O"}
{"X":52087,"RHEA_ID":50661,"compounds":"3-(3-methylsulfanyl)propylmalate => 2-(2-methylsulfanyl)propylmaleate + H2O"}
{"X":52088,"RHEA_ID":60855,"compounds":"a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-homocysteine"}
{"X":52089,"RHEA_ID":50663,"DIRECTION":"BI","MASTER_ID":50660,"metacyc":"RXN-18185","compounds":"3-(3-methylsulfanyl)propylmalate <=> 2-(2-methylsulfanyl)propylmaleate + H2O"}
{"X":52090,"RHEA_ID":50664,"DIRECTION":"UN","MASTER_ID":50664,"ec":"2.4.1.69","compounds":"a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GlcNAc derivative + GDP + H(+)"}
{"X":52091,"RHEA_ID":62127,"compounds":"a 2'-deoxyribonucleoside 5'-phosphate + GTP <=> a 2'-deoxyribonucleoside 5'-diphosphate + GDP"}
{"X":52092,"RHEA_ID":50666,"compounds":"an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GlcNAc derivative + GDP + H(+) => a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose"}
{"X":52093,"RHEA_ID":60859,"compounds":"a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-homocysteine"}
{"X":52094,"RHEA_ID":50668,"DIRECTION":"UN","MASTER_ID":50668,"ec":"2.4.1.344","compounds":"a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP + H(+)"}
{"X":52095,"RHEA_ID":50669,"DIRECTION":"LR","MASTER_ID":50668,"metacyc":"RXN-18235","compounds":"a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose => an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP + H(+)"}
{"X":52096,"RHEA_ID":60863,"compounds":"a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-adenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":52097,"RHEA_ID":57313,"compounds":"H2O + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine => cytidine 5'-diphosphoramidate + H(+) + L-glutamate"}
{"X":52098,"RHEA_ID":50672,"compounds":"[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + H2O = [(1->4)-N-acetyl-beta-D-glucosaminyl](n-2) + N,N'-diacetylchitobiose"}
{"X":52099,"RHEA_ID":50673,"DIRECTION":"LR","MASTER_ID":50672,"metacyc":"RXN-12309","compounds":"[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + H2O => [(1->4)-N-acetyl-beta-D-glucosaminyl](n-2) + N,N'-diacetylchitobiose"}
{"X":52100,"RHEA_ID":53987,"compounds":"(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O <=> (11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate"}
{"X":52101,"RHEA_ID":60868,"DIRECTION":"UN","MASTER_ID":60868,"ec":"3.6.1.62","compounds":"a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O = a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(7)-methylguanosine 5'-diphosphate"}
{"X":52102,"RHEA_ID":50676,"DIRECTION":"UN","MASTER_ID":50676,"ec":"3.5.1.121","compounds":"H(+) + H2O + N-terminal L-asparaginyl-[protein] = N-terminal L-aspartyl-[protein] + NH4(+)"}
{"X":52103,"RHEA_ID":50677,"DIRECTION":"LR","MASTER_ID":50676,"metacyc":"RXN-17849","compounds":"H(+) + H2O + N-terminal L-asparaginyl-[protein] => N-terminal L-aspartyl-[protein] + NH4(+)"}
{"X":52104,"RHEA_ID":53991,"compounds":"[myosin light chain]-O-phospho-L-threonine + H2O <=> [myosin light chain]-L-threonine + phosphate"}
{"X":52105,"RHEA_ID":60872,"DIRECTION":"UN","MASTER_ID":60872,"ec":"3.6.1.62","compounds":"a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O = a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(7)-methylguanosine 5'-diphosphate"}
{"X":52106,"RHEA_ID":50680,"DIRECTION":"UN","MASTER_ID":50680,"ec":"3.5.1.122","compounds":"H2O + N-terminal L-glutaminyl-[protein] = N-terminal L-glutamyl-[protein] + NH4(+)"}
{"X":52107,"RHEA_ID":62142,"compounds":"dTDP + GDP => dTMP + GTP"}
{"X":52108,"RHEA_ID":60875,"compounds":"a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O <=> a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(7)-methylguanosine 5'-diphosphate"}
{"X":52109,"RHEA_ID":53997,"compounds":"(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O => (14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate"}
{"X":52110,"RHEA_ID":50685,"DIRECTION":"LR","MASTER_ID":50684,"metacyc":"RXN-15251","compounds":"H2O + N(5)-phenyl-L-glutamine => aniline + H(+) + L-glutamate"}
{"X":52111,"RHEA_ID":53999,"compounds":"(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O <=> (14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate"}
{"X":52112,"RHEA_ID":54000,"compounds":"(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = (11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate"}
{"X":52113,"RHEA_ID":50692,"DIRECTION":"UN","MASTER_ID":50692,"ec":"2.4.1.342","compounds":"ADP-alpha-D-glucose + alpha-D-glucose 1-phosphate = ADP + alpha-maltose 1-phosphate + H(+)"}
{"X":52114,"RHEA_ID":50693,"DIRECTION":"LR","MASTER_ID":50692,"metacyc":"RXN-18305","compounds":"ADP-alpha-D-glucose + alpha-D-glucose 1-phosphate => ADP + alpha-maltose 1-phosphate + H(+)"}
{"X":52115,"RHEA_ID":60883,"compounds":"a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O <=> a 5'-end phospho-ribonucleoside in mRNA + H(+) + NAD(+)"}
{"X":52116,"RHEA_ID":60884,"compounds":"a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine-phospho-ribonucleoside in mRNA + H2O = (N(7)-methyl 5'-triphospho-guanosine)-adenosine + a 5'-end phospho-ribonucleoside in mRNA + H(+)"}
{"X":52117,"RHEA_ID":50696,"DIRECTION":"UN","MASTER_ID":50696,"ec":"1.14.15.22","compounds":"calciol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = calcidiol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":52118,"RHEA_ID":50697,"DIRECTION":"LR","MASTER_ID":50696,"metacyc":"RXN-18214","compounds":"calciol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => calcidiol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":52119,"RHEA_ID":60886,"compounds":"(N(7)-methyl 5'-triphospho-guanosine)-adenosine + a 5'-end phospho-ribonucleoside in mRNA + H(+) => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine-phospho-ribonucleoside in mRNA + H2O"}
{"X":52120,"RHEA_ID":54008,"compounds":"(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = (8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate"}
{"X":52121,"RHEA_ID":50700,"DIRECTION":"UN","MASTER_ID":50700,"ec":"1.14.15.22","compounds":"calcidiol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = calcitriol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":52122,"RHEA_ID":60889,"compounds":"a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine-phospho-ribonucleoside in mRNA + H2O => (N(7)-methyl 5'-triphospho-guanosine)-guanosine + a 5'-end phospho-ribonucleoside in mRNA + H(+)"}
{"X":52123,"RHEA_ID":57344,"compounds":"3-hydroxy-D-kynurenine + S-adenosyl-L-methionine = 3-hydroxy-4-methyl-D-kynurenine + H(+) + S-adenosyl-L-homocysteine"}
{"X":52124,"RHEA_ID":57345,"DIRECTION":"LR","MASTER_ID":57344,"metacyc":"RXN-17068","compounds":"3-hydroxy-D-kynurenine + S-adenosyl-L-methionine => 3-hydroxy-4-methyl-D-kynurenine + H(+) + S-adenosyl-L-homocysteine"}
{"X":52125,"RHEA_ID":50704,"compounds":"1-propanol + NAD(+) = H(+) + NADH + propanal"}
{"X":52126,"RHEA_ID":50705,"compounds":"1-propanol + NAD(+) => H(+) + NADH + propanal"}
{"X":52127,"RHEA_ID":54015,"compounds":"(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O <=> (8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate"}
{"X":52128,"RHEA_ID":57349,"DIRECTION":"LR","MASTER_ID":57348,"metacyc":"RXN-17500","compounds":"3-hydroxy-4-methyl-L-kynurenine + H2O => 3-hydroxy-4-methylanthranilate + H(+) + L-alanine"}
{"X":52129,"RHEA_ID":50708,"compounds":"(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O"}
{"X":52130,"RHEA_ID":50709,"DIRECTION":"LR","MASTER_ID":50708,"reactome":"R-HSA-2161999.2","compounds":"(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione => (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O"}
{"X":52131,"RHEA_ID":60902,"compounds":"an N(3)-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in RNA + S-adenosyl-L-methionine"}
{"X":52132,"RHEA_ID":57353,"DIRECTION":"LR","MASTER_ID":57352,"metacyc":"RXN-5962","compounds":"O2 + reduced [NADPH--hemoprotein reductase] + zeinoxanthin => H(+) + H2O + lutein + oxidized [NADPH--hemoprotein reductase]"}
{"X":52133,"RHEA_ID":54021,"compounds":"L-lysyl-[protein] + propanoyl-CoA => CoA + H(+) + N(6)-propanoyl-L-lysyl-[protein]"}
{"X":52134,"RHEA_ID":50713,"DIRECTION":"LR","MASTER_ID":50712,"metacyc":"RXN-17996","compounds":"chloride + FADH2 + O2 + tetracycline => 7-chlorotetracycline + FAD + H(+) + 2 H2O"}
{"X":52135,"RHEA_ID":57356,"DIRECTION":"UN","MASTER_ID":57356,"ec":"1.14.20.14","compounds":"2-oxoglutarate + chloride + H(+) + hapalindole U + O2 = CO2 + H2O + hapalindole G + succinate"}
{"X":52136,"RHEA_ID":54024,"compounds":"2-oxoglutarate + L-histidyl-[ribosomal protein uL15] + O2 = (3S)-3-hydroxy-L-histidyl-[ribosomal protein uL15] + CO2 + succinate"}
{"X":52137,"RHEA_ID":54025,"compounds":"2-oxoglutarate + L-histidyl-[ribosomal protein uL15] + O2 => (3S)-3-hydroxy-L-histidyl-[ribosomal protein uL15] + CO2 + succinate"}
{"X":52138,"RHEA_ID":50717,"DIRECTION":"LR","MASTER_ID":50716,"metacyc":"RXN-14709","compounds":"dimethyl sulfone + FMNH2 + O2 => FMN + formaldehyde + 2 H(+) + H2O + methanesulfinate"}
{"X":52139,"RHEA_ID":50718,"compounds":"FMN + formaldehyde + 2 H(+) + H2O + methanesulfinate => dimethyl sulfone + FMNH2 + O2"}
{"X":52140,"RHEA_ID":54028,"DIRECTION":"UN","MASTER_ID":54028,"ec":"1.14.14.154","compounds":"a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = a Delta(14) steroid + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}
{"X":52141,"RHEA_ID":54029,"DIRECTION":"LR","MASTER_ID":54028,"metacyc":"RXN-13961","compounds":"a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => a Delta(14) steroid + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}
{"X":52142,"RHEA_ID":50721,"DIRECTION":"LR","MASTER_ID":50720,"metacyc":"RXN-14710","compounds":"FMNH2 + methanesulfinate + O2 => FMN + H(+) + H2O + methanesulfonate"}
{"X":52143,"RHEA_ID":57364,"compounds":"H2O + NADH = (6S)-NADHX"}
{"X":52144,"RHEA_ID":57365,"DIRECTION":"LR","MASTER_ID":57364,"ecocyc":"RXN-12753","metacyc":"RXN-12753","compounds":"H2O + NADH => (6S)-NADHX"}
{"X":52145,"RHEA_ID":50724,"compounds":"(E)-4-hydroxyphenylacetaldehyde oxime = (Z)-(4-hydroxyphenyl)acetaldehyde oxime"}
{"X":52146,"RHEA_ID":54034,"compounds":"(6S)-5,6,7,8-tetrahydrofolate + dTDP-4-formamido-4,6-dideoxy-alpha-D-glucose + H(+) => (6S)-10-formyltetrahydrofolate + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose"}
{"X":52147,"RHEA_ID":57368,"compounds":"H2O + NADPH = (6R)-NADPHX"}
{"X":52148,"RHEA_ID":57369,"compounds":"H2O + NADPH => (6R)-NADPHX"}
{"X":52149,"RHEA_ID":60921,"compounds":"2-oxoglutarate + an N(3)-methylcytidine in mRNA + O2 => a cytidine in mRNA + CO2 + formaldehyde + succinate"}
{"X":52150,"RHEA_ID":54038,"compounds":"[mycoredoxin]-S-mycothiol-L-cysteine + arsenite => [mycoredoxin]-L-cysteine + arseno-mycothiol + H(+)"}
{"X":52151,"RHEA_ID":57372,"compounds":"H2O + NADPH = (6S)-NADPHX"}
{"X":52152,"RHEA_ID":57373,"compounds":"H2O + NADPH => (6S)-NADPHX"}
{"X":52153,"RHEA_ID":60925,"DIRECTION":"LR","MASTER_ID":60924,"metacyc":"RXN-8661","compounds":"2-oxoglutarate + N(6)-methyl-L-lysyl-[protein] + O2 => CO2 + formaldehyde + L-lysyl-[protein] + succinate"}
{"X":52154,"RHEA_ID":54042,"compounds":"(3E,7E)-dolathalia-3,7,11-triene + diphosphate => all-trans-geranylgeranyl diphosphate"}
{"X":52155,"RHEA_ID":57376,"DIRECTION":"UN","MASTER_ID":57376,"ec":"1.14.14.166","compounds":"(S)-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] = (S)-1-hydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52156,"RHEA_ID":57377,"DIRECTION":"LR","MASTER_ID":57376,"metacyc":"RXN-13807","compounds":"(S)-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] => (S)-1-hydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52157,"RHEA_ID":54045,"DIRECTION":"LR","MASTER_ID":54044,"metacyc":"RXN-18823","compounds":"(2E,6E)-farnesyl diphosphate + H2O => 7-epi-alpha-eudesmol + diphosphate"}
{"X":52158,"RHEA_ID":54046,"compounds":"7-epi-alpha-eudesmol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}
{"X":52159,"RHEA_ID":50738,"compounds":"a quinol + thiosulfate => a quinone + 2 H(+) + hydrogen sulfide + sulfite"}
{"X":52160,"RHEA_ID":60932,"compounds":"(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] = 17-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52161,"RHEA_ID":60933,"compounds":"(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] => 17-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52162,"RHEA_ID":54050,"compounds":"4-epi-cubebol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}
{"X":52163,"RHEA_ID":50742,"compounds":"glycine + leukotriene F4 => H2O + leukotriene C4"}
{"X":52164,"RHEA_ID":54052,"DIRECTION":"UN","MASTER_ID":54052,"ec":"4.2.3.173","compounds":"(2E,6E)-farnesyl diphosphate + H2O = diphosphate + tau-cadinol"}
{"X":52165,"RHEA_ID":60937,"compounds":"an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => an (omega-1)-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52166,"RHEA_ID":54054,"compounds":"diphosphate + tau-cadinol => (2E,6E)-farnesyl diphosphate + H2O"}
{"X":52167,"RHEA_ID":60938,"compounds":"an (omega-1)-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":52168,"RHEA_ID":54056,"DIRECTION":"UN","MASTER_ID":54056,"ec":"4.2.3.174","compounds":"(2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-hedycaryol + diphosphate"}
{"X":52169,"RHEA_ID":50748,"compounds":"H2O + juglone = naphthalene-1,2,4,8-tetrol"}
{"X":52170,"RHEA_ID":54058,"compounds":"(2E,6E)-hedycaryol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}
{"X":52171,"RHEA_ID":50750,"compounds":"naphthalene-1,2,4,8-tetrol => H2O + juglone"}
{"X":52172,"RHEA_ID":54060,"DIRECTION":"UN","MASTER_ID":54060,"ec":"4.2.3.187","compounds":"(2E,6E)-farnesyl diphosphate + H2O = (2Z,6E)-hedycaryol + diphosphate"}
{"X":52173,"RHEA_ID":54061,"DIRECTION":"LR","MASTER_ID":54060,"metacyc":"RXN-18944","compounds":"(2E,6E)-farnesyl diphosphate + H2O => (2Z,6E)-hedycaryol + diphosphate"}
{"X":52174,"RHEA_ID":54062,"compounds":"(2Z,6E)-hedycaryol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}
{"X":52175,"RHEA_ID":57396,"DIRECTION":"UN","MASTER_ID":57396,"ec":"2.1.1.352","compounds":"(S)-S-adenosyl-L-methionine + 3-O-acetyl-4'-O-demethylpapaveroxine = 3-O-acetylpapaveroxine + H(+) + S-adenosyl-L-homocysteine"}
{"X":52176,"RHEA_ID":60947,"compounds":"quercetin + S-adenosyl-L-methionine <=> H(+) + isorhamnetin + S-adenosyl-L-homocysteine"}
{"X":52177,"RHEA_ID":57398,"compounds":"3-O-acetylpapaveroxine + H(+) + S-adenosyl-L-homocysteine => (S)-S-adenosyl-L-methionine + 3-O-acetyl-4'-O-demethylpapaveroxine"}
{"X":52178,"RHEA_ID":54066,"compounds":"10-epi-cubebol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}
{"X":52179,"RHEA_ID":50758,"DIRECTION":"RL","MASTER_ID":50756,"ecocyc":"FLAVONADPREDUCT-RXN","metacyc":"FLAVONADPREDUCT-RXN","compounds":"2 H(+) + NADPH + oxidized [flavodoxin] => NADP(+) + reduced [flavodoxin]"}
{"X":52180,"RHEA_ID":62221,"DIRECTION":"LR","MASTER_ID":62220,"metacyc":"RXN-15483","compounds":"phyllostine => neopatulin"}
{"X":52181,"RHEA_ID":54069,"DIRECTION":"LR","MASTER_ID":54068,"metacyc":"RXN-18855","compounds":"(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O => diphosphate + sesterfisherol"}
{"X":52182,"RHEA_ID":54070,"compounds":"diphosphate + sesterfisherol => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O"}
{"X":52183,"RHEA_ID":50762,"compounds":"a quinol + sulfate => a quinone + H2O + sulfite"}
{"X":52184,"RHEA_ID":57405,"DIRECTION":"LR","MASTER_ID":57404,"metacyc":"RXN-13812","compounds":"NAD(+) + narcotine hemiacetal => H(+) + NADH + noscapine"}
{"X":52185,"RHEA_ID":57406,"compounds":"H(+) + NADH + noscapine => NAD(+) + narcotine hemiacetal"}
{"X":52186,"RHEA_ID":54074,"compounds":"beta-thujene + diphosphate => (2E)-geranyl diphosphate"}
{"X":52187,"RHEA_ID":57408,"DIRECTION":"UN","MASTER_ID":57408,"ec":"1.1.1.237","compounds":"(2R)-3-(3,4-dihydroxyphenyl)lactate + NAD(+) = 3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADH"}
{"X":52188,"RHEA_ID":60959,"compounds":"17-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose <=> (9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + H(+) + UDP"}
{"X":52189,"RHEA_ID":54077,"DIRECTION":"LR","MASTER_ID":54076,"metacyc":"RXN-17161","compounds":"(2E,6E,10E,14E)-geranylfarnesyl diphosphate => diphosphate + stellata-2,6,19-triene"}
{"X":52190,"RHEA_ID":54078,"compounds":"diphosphate + stellata-2,6,19-triene => (2E,6E,10E,14E)-geranylfarnesyl diphosphate"}
{"X":52191,"RHEA_ID":50770,"compounds":"anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine => 4-methylamino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine"}
{"X":52192,"RHEA_ID":57413,"compounds":"AMP + diphosphate + L-tyrosinal + NADP(+) => ATP + H(+) + L-tyrosine + NADPH"}
{"X":52193,"RHEA_ID":50772,"DIRECTION":"UN","MASTER_ID":50772,"ec":"1.7.3.1","compounds":"H2O + nitroethane + O2 = acetaldehyde + H(+) + H2O2 + nitrite"}
{"X":52194,"RHEA_ID":54082,"compounds":"5-methoxycarbonylmethoxyuridine(34) in tRNA + S-adenosyl-L-homocysteine => 5-carboxymethoxyuridine(34) in tRNA + S-adenosyl-L-methionine"}
{"X":52195,"RHEA_ID":50774,"compounds":"acetaldehyde + H(+) + H2O2 + nitrite => H2O + nitroethane + O2"}
{"X":52196,"RHEA_ID":60972,"compounds":"hexan-1-ol + NAD(+) = H(+) + hexanal + NADH"}
{"X":52197,"RHEA_ID":54085,"compounds":"7-cyano-7-carbaguanosine(15) in tRNA + H2O + L-glutamine => archaeosine(15) in tRNA + L-glutamate"}
{"X":52198,"RHEA_ID":60974,"DIRECTION":"RL","MASTER_ID":60972,"metacyc":"HEXANOL-RXN","compounds":"H(+) + hexanal + NADH => hexan-1-ol + NAD(+)"}
{"X":52199,"RHEA_ID":57420,"compounds":"NADH + 2 oxidized [cytochrome P450] = H(+) + NAD(+) + 2 reduced [cytochrome P450]"}
{"X":52200,"RHEA_ID":60975,"compounds":"hexan-1-ol + NAD(+) <=> H(+) + hexanal + NADH"}
{"X":52201,"RHEA_ID":54089,"compounds":"3,4-dihydroxyphenylacetate + H(+) + NADH + O2 => 2,4,5-trihydroxyphenylacetate + H2O + NAD(+)"}
{"X":52202,"RHEA_ID":54090,"compounds":"2,4,5-trihydroxyphenylacetate + H2O + NAD(+) => 3,4-dihydroxyphenylacetate + H(+) + NADH + O2"}
{"X":52203,"RHEA_ID":57424,"compounds":"guaiacol + O2 + reduced [NADH--hemoprotein reductase] = catechol + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]"}
{"X":52204,"RHEA_ID":57425,"compounds":"guaiacol + O2 + reduced [NADH--hemoprotein reductase] => catechol + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]"}
{"X":52205,"RHEA_ID":54093,"compounds":"3,4-dihydroxyphenylacetate + H(+) + NADPH + O2 => 2,4,5-trihydroxyphenylacetate + H2O + NADP(+)"}
{"X":52206,"RHEA_ID":60982,"compounds":"12-oxododecanoate + H(+) + NADH => 12-hydroxydodecanoate + NAD(+)"}
{"X":52207,"RHEA_ID":57428,"compounds":"anisole + O2 + reduced [NADH--hemoprotein reductase] = formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] + phenol"}
{"X":52208,"RHEA_ID":57429,"compounds":"anisole + O2 + reduced [NADH--hemoprotein reductase] => formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] + phenol"}
{"X":52209,"RHEA_ID":50788,"compounds":"NADP(+) + pentan-2-one = 2-oxo-(3E)-pentene + H(+) + NADPH"}
{"X":52210,"RHEA_ID":60986,"compounds":"16-oxohexadecanoate + H(+) + NADH => 16-hydroxyhexadecanoate + NAD(+)"}
{"X":52211,"RHEA_ID":54098,"compounds":"H(+) + N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine"}
{"X":52212,"RHEA_ID":57433,"compounds":"3-methoxycatechol + O2 + reduced [NADH--hemoprotein reductase] => 1,2,3-trihydroxybenzene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]"}
{"X":52213,"RHEA_ID":50792,"compounds":"18-hydroxycorticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] = aldosterone + 2 H2O + 2 oxidized [adrenodoxin]"}
{"X":52214,"RHEA_ID":60990,"compounds":"(E)-2-hexenal + H(+) + NADH => (E)-hex-2-en-1-ol + NAD(+)"}
{"X":52215,"RHEA_ID":50794,"compounds":"aldosterone + 2 H2O + 2 oxidized [adrenodoxin] => 18-hydroxycorticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}
{"X":52216,"RHEA_ID":60991,"compounds":"(E)-hex-2-en-1-ol + NAD(+) <=> (E)-2-hexenal + H(+) + NADH"}
{"X":52217,"RHEA_ID":50796,"compounds":"glutathione + prostaglandin A2 = prostaglandin A2-S-(R)-glutathione"}
{"X":52218,"RHEA_ID":54104,"DIRECTION":"UN","MASTER_ID":54104,"ec":"2.1.1.299","compounds":"N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":52219,"RHEA_ID":54105,"DIRECTION":"LR","MASTER_ID":54104,"metacyc":"RXN-12889","compounds":"N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":52220,"RHEA_ID":60999,"compounds":"H2O + L-leucine + O2 <=> 4-methyl-2-oxopentanoate + H2O2 + NH4(+)"}
{"X":52221,"RHEA_ID":50800,"compounds":"glutathione + prostaglandin A2 = prostaglandin A2-S-(S)-glutathione"}
{"X":52222,"RHEA_ID":50801,"compounds":"glutathione + prostaglandin A2 => prostaglandin A2-S-(S)-glutathione"}
{"X":52223,"RHEA_ID":54108,"DIRECTION":"UN","MASTER_ID":54108,"ec":"4.2.3.179","compounds":"(2E,6E)-farnesyl diphosphate = diphosphate + guaia-4,6-diene"}
{"X":52224,"RHEA_ID":61028,"compounds":"itaconate + L-cysteinyl-[protein] = S-(2,3-dicarboxypropyl)-L-cysteinyl-[protein]"}
{"X":52225,"RHEA_ID":54110,"compounds":"diphosphate + guaia-4,6-diene => (2E,6E)-farnesyl diphosphate"}
{"X":52226,"RHEA_ID":61029,"compounds":"itaconate + L-cysteinyl-[protein] => S-(2,3-dicarboxypropyl)-L-cysteinyl-[protein]"}
{"X":52227,"RHEA_ID":54112,"DIRECTION":"UN","MASTER_ID":54112,"ec":"4.2.3.181","compounds":"(2E,6E)-farnesyl diphosphate = diphosphate + selina-4(15),7(11)-diene"}
{"X":52228,"RHEA_ID":50807,"compounds":"glutathione + prostaglandin J2 <=> prostaglandin J2-S-(R)-glutathione"}
{"X":52229,"RHEA_ID":50808,"compounds":"glutathione + prostaglandin J2 = prostaglandin J2-S-(S)-glutathione"}
{"X":52230,"RHEA_ID":50809,"compounds":"glutathione + prostaglandin J2 => prostaglandin J2-S-(S)-glutathione"}
{"X":52231,"RHEA_ID":54116,"DIRECTION":"UN","MASTER_ID":54116,"ec":"4.2.3.180","compounds":"all-trans-geranylgeranyl diphosphate = diphosphate + pseudolaratriene"}
{"X":52232,"RHEA_ID":61040,"compounds":"(+)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase] = (+)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52233,"RHEA_ID":57454,"compounds":"H(+) + N(5)-methyl-L-glutaminyl-[protein] + S-adenosyl-L-homocysteine => L-glutaminyl-[protein] + S-adenosyl-L-methionine"}
{"X":52234,"RHEA_ID":62275,"compounds":"4 (R)-2-hydroxy-3-methylbutyrate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine <=> 8 AMP + bassianolide + 8 diphosphate + 8 H(+) + 4 S-adenosyl-L-homocysteine"}
{"X":52235,"RHEA_ID":54120,"compounds":"coelenterazine h + O2 = coelenterazine h dioxetanone"}
{"X":52236,"RHEA_ID":61044,"compounds":"(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] = (-)-(R)-19-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52237,"RHEA_ID":50816,"compounds":"androst-4-ene-3,17-dione + H(+) + NADPH = 5alpha-androstan-3,17-dione + NADP(+)"}
{"X":52238,"RHEA_ID":54123,"compounds":"coelenterazine h + O2 <=> coelenterazine h dioxetanone"}
{"X":52239,"RHEA_ID":54124,"compounds":"coelenterazine h dioxetanone = CO2 + excited coelenteramide h monoanion + H(+)"}
{"X":52240,"RHEA_ID":61048,"compounds":"lochnericine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + horhammericine + oxidized [NADPH--hemoprotein reductase]"}
{"X":52241,"RHEA_ID":50820,"DIRECTION":"UN","MASTER_ID":50820,"ec":"1.3.1.22","compounds":"17beta-hydroxy-5alpha-androstan-3-one + NADP(+) = H(+) + NADPH + testosterone"}
{"X":52242,"RHEA_ID":61050,"compounds":"H(+) + H2O + horhammericine + oxidized [NADPH--hemoprotein reductase] => lochnericine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":52243,"RHEA_ID":54128,"compounds":"3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP"}
{"X":52244,"RHEA_ID":61052,"compounds":"(-)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase] = (-)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52245,"RHEA_ID":61053,"compounds":"(-)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase] => (-)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52246,"RHEA_ID":61054,"compounds":"(-)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":52247,"RHEA_ID":54132,"compounds":"a ribonucleoside 5'-diphosphate-alpha-D-glucose + D-glucose 6-phosphate = a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose 6-phosphate + H(+)"}
{"X":52248,"RHEA_ID":61056,"compounds":"(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + lochnericine + oxidized [NADPH--hemoprotein reductase]"}
{"X":52249,"RHEA_ID":54134,"compounds":"a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose 6-phosphate + H(+) => a ribonucleoside 5'-diphosphate-alpha-D-glucose + D-glucose 6-phosphate"}
{"X":52250,"RHEA_ID":54135,"compounds":"a ribonucleoside 5'-diphosphate-alpha-D-glucose + D-glucose 6-phosphate <=> a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose 6-phosphate + H(+)"}
{"X":52251,"RHEA_ID":62296,"compounds":"(+)-premalbrancheamide + 2 chloride + 2 FAD + 4 H(+) = (+)-malbrancheamide + 2 FADH2"}
{"X":52252,"RHEA_ID":61068,"compounds":"acetyl-CoA + horhammericine = 19-O-acetylhorhammericine + CoA"}
{"X":52253,"RHEA_ID":61069,"compounds":"acetyl-CoA + horhammericine => 19-O-acetylhorhammericine + CoA"}
{"X":52254,"RHEA_ID":61070,"compounds":"19-O-acetylhorhammericine + CoA => acetyl-CoA + horhammericine"}
{"X":52255,"RHEA_ID":54140,"compounds":"cytidine(49) in tRNA precursor + S-adenosyl-L-methionine = 5-methylcytidine(49) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine"}
{"X":52256,"RHEA_ID":61072,"compounds":"(-)-(R)-19-hydroxytabersonine + acetyl-CoA = (-)-(R)-19-O-acetyltabersonine + CoA"}
{"X":52257,"RHEA_ID":61073,"compounds":"(-)-(R)-19-hydroxytabersonine + acetyl-CoA => (-)-(R)-19-O-acetyltabersonine + CoA"}
{"X":52258,"RHEA_ID":50837,"compounds":"(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 => 14-hydroperoxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoate"}
{"X":52259,"RHEA_ID":50838,"compounds":"14-hydroperoxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoate => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2"}
{"X":52260,"RHEA_ID":50839,"compounds":"(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 <=> 14-hydroperoxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoate"}
{"X":52261,"RHEA_ID":50840,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate"}
{"X":52262,"RHEA_ID":61078,"compounds":"(-)-echitovenine + CoA => (-)-minovincinine + acetyl-CoA"}
{"X":52263,"RHEA_ID":54148,"DIRECTION":"UN","MASTER_ID":54148,"ec":"4.2.1.131","compounds":"1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene = 1-hydroxy-all-trans-1,2-dihydro-neurosporene + H2O"}
{"X":52264,"RHEA_ID":61080,"compounds":"(+)-minovincinine + acetyl-CoA = (+)-echitovenine + CoA"}
{"X":52265,"RHEA_ID":61081,"compounds":"(+)-minovincinine + acetyl-CoA => (+)-echitovenine + CoA"}
{"X":52266,"RHEA_ID":61082,"compounds":"(+)-echitovenine + CoA => (+)-minovincinine + acetyl-CoA"}
{"X":52267,"RHEA_ID":50846,"compounds":"(5S,6S)-epoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O => (5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate"}
{"X":52268,"RHEA_ID":61084,"compounds":"(S)-naringenin + 2-oxoglutarate + O2 = (2R,3R)-dihydrokaempferol + CO2 + succinate"}
{"X":52269,"RHEA_ID":50848,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoate + A + H2O"}
{"X":52270,"RHEA_ID":61086,"compounds":"(2R,3R)-dihydrokaempferol + CO2 + succinate => (S)-naringenin + 2-oxoglutarate + O2"}
{"X":52271,"RHEA_ID":54156,"compounds":"2-oxoglutarate + [ribosomal protein uS12]-L-proline + O2 = [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + CO2 + succinate"}
{"X":52272,"RHEA_ID":61088,"compounds":"(S)-eriodictyol + 2-oxoglutarate + O2 = (2R,3R)-dihydroquercetin + CO2 + succinate"}
{"X":52273,"RHEA_ID":50852,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O"}
{"X":52274,"RHEA_ID":61090,"compounds":"(2R,3R)-dihydroquercetin + CO2 + succinate => (S)-eriodictyol + 2-oxoglutarate + O2"}
{"X":52275,"RHEA_ID":50854,"compounds":"(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2"}
{"X":52276,"RHEA_ID":50855,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 <=> (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O"}
{"X":52277,"RHEA_ID":61093,"DIRECTION":"LR","MASTER_ID":61092,"metacyc":"RXN-7933","compounds":"H2O + N(2)-acetyl-L-citrulline => acetate + L-citrulline"}
{"X":52278,"RHEA_ID":61094,"compounds":"acetate + L-citrulline => H2O + N(2)-acetyl-L-citrulline"}
{"X":52279,"RHEA_ID":50858,"compounds":"(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2"}
{"X":52280,"RHEA_ID":50859,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 <=> (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O"}
{"X":52281,"RHEA_ID":61097,"DIRECTION":"LR","MASTER_ID":61096,"metacyc":"RXN-7652","compounds":"(S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] => (S)-eriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52282,"RHEA_ID":61098,"compounds":"(S)-eriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":52283,"RHEA_ID":50862,"compounds":"13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O => (9Z,12Z)-octadecadienoate + AH2 + O2"}
{"X":52284,"RHEA_ID":61100,"compounds":"(S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase] = (2S)-dihydrotricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52285,"RHEA_ID":50864,"compounds":"(9Z,12Z)-octadecadienoate + AH2 + O2 = 9-hydroxy-(10E,12Z)-octadecadienoate + A + H2O"}
{"X":52286,"RHEA_ID":61102,"compounds":"(2S)-dihydrotricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":52287,"RHEA_ID":54172,"compounds":"H2O + N(6)-acyl-L-lysyl-[protein] + NAD(+) = L-lysyl-[protein] + nicotinamide + O-acyl-ADP-D-ribose"}
{"X":52288,"RHEA_ID":61104,"compounds":"(S)-naringenin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (2S)-dihydrotricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":52289,"RHEA_ID":61105,"DIRECTION":"LR","MASTER_ID":61104,"metacyc":"RXN-13717","compounds":"(S)-naringenin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (2S)-dihydrotricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":52290,"RHEA_ID":61106,"compounds":"(2S)-dihydrotricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => (S)-naringenin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}
{"X":52291,"RHEA_ID":54176,"DIRECTION":"UN","MASTER_ID":54176,"ec":"1.2.1.80","compounds":"a long-chain fatty aldehyde + holo-[ACP] + NADP(+) = a long-chain fatty acyl-[ACP] + H(+) + NADPH"}
{"X":52292,"RHEA_ID":50871,"compounds":"(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 <=> (5,12,18R)-trihydroxy-(6Z,8E,10E,14Z,16E)-eicosapentaenoate"}
{"X":52293,"RHEA_ID":61109,"DIRECTION":"LR","MASTER_ID":61108,"metacyc":"RXN-7782","compounds":"(2R,3R)-dihydrokaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (2R,3R)-dihydromyricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":52294,"RHEA_ID":61110,"compounds":"(2R,3R)-dihydromyricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => (2R,3R)-dihydrokaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}
{"X":52295,"RHEA_ID":51971,"compounds":"(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 <=> (5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate"}
{"X":52296,"RHEA_ID":61112,"compounds":"(2R,3R)-dihydrokaempferol + O2 + reduced [NADPH--hemoprotein reductase] = (2R,3R)-dihydroquercetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52297,"RHEA_ID":61113,"DIRECTION":"LR","MASTER_ID":61112,"metacyc":"RXN-525","compounds":"(2R,3R)-dihydrokaempferol + O2 + reduced [NADPH--hemoprotein reductase] => (2R,3R)-dihydroquercetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52298,"RHEA_ID":61114,"compounds":"(2R,3R)-dihydroquercetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2R,3R)-dihydrokaempferol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":52299,"RHEA_ID":57528,"compounds":"5'-end ribonucleotide-RNA + a ribonucleoside 5'-triphosphate + ATP + H2O = 5'-phospho-ribonucleosidyl-ribonucleotide-RNA + AMP + 2 diphosphate + H(+)"}
{"X":52300,"RHEA_ID":61116,"compounds":"(2R,3R)-dihydroquercetin + O2 + reduced [NADPH--hemoprotein reductase] = (2R,3R)-dihydromyricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52301,"RHEA_ID":61117,"DIRECTION":"LR","MASTER_ID":61116,"metacyc":"RXN-13718","compounds":"(2R,3R)-dihydroquercetin + O2 + reduced [NADPH--hemoprotein reductase] => (2R,3R)-dihydromyricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52302,"RHEA_ID":61118,"compounds":"(2R,3R)-dihydromyricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2R,3R)-dihydroquercetin + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":52303,"RHEA_ID":57532,"compounds":"5'-end ribonucleotide-RNA + ATP + H(+) = adenosine-5'-diphospho-5'-ribonucleotide-RNA + diphosphate"}
{"X":52304,"RHEA_ID":54189,"compounds":"H2O + N-acetyl-L-phenylalanine => acetate + L-phenylalanine"}
{"X":52305,"RHEA_ID":61121,"compounds":"kaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 2 H(+) + 2 H2O + myricetin + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":52306,"RHEA_ID":61122,"compounds":"2 H(+) + 2 H2O + myricetin + 2 oxidized [NADPH--hemoprotein reductase] => kaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}
{"X":52307,"RHEA_ID":50886,"compounds":"(9Z-octadecenoyl)-glycerol + phosphate => (9Z)-octadecenoyl-sn-glycero-3-phosphate + H2O"}
{"X":52308,"RHEA_ID":61124,"compounds":"kaempferol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + quercetin"}
{"X":52309,"RHEA_ID":61125,"DIRECTION":"LR","MASTER_ID":61124,"metacyc":"RXN-12510","compounds":"kaempferol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + quercetin"}
{"X":52310,"RHEA_ID":61126,"compounds":"H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + quercetin => kaempferol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":52311,"RHEA_ID":50890,"compounds":"N-acyl-sphingoid base + phosphate => an N-acylsphingoid base 1-phosphate + H2O"}
{"X":52312,"RHEA_ID":57541,"compounds":"5'-NTP-ribonucleotide-RNA + H2O => 5'-phospho-ribonucleosidyl-ribonucleotide-RNA + diphosphate + H(+)"}
{"X":52313,"RHEA_ID":54198,"compounds":"H(+) + N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-methionine"}
{"X":52314,"RHEA_ID":61130,"compounds":"H(+) + H2O + myricetin + oxidized [NADPH--hemoprotein reductase] => O2 + quercetin + reduced [NADPH--hemoprotein reductase]"}
{"X":52315,"RHEA_ID":50894,"compounds":"a menaquinol + thiosulfate => a menaquinone + 2 H(+) + hydrogen sulfide + sulfite"}
{"X":52316,"RHEA_ID":61132,"compounds":"(2R,3R)-dihydrokaempferol + 2-oxoglutarate + O2 = CO2 + H(+) + H2O + kaempferol + succinate"}
{"X":52317,"RHEA_ID":54202,"compounds":"H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-methionine"}
{"X":52318,"RHEA_ID":61134,"compounds":"CO2 + H(+) + H2O + kaempferol + succinate => (2R,3R)-dihydrokaempferol + 2-oxoglutarate + O2"}
{"X":52319,"RHEA_ID":50898,"compounds":"(8,11R,12S)-trihydroxy-(5Z,9E,14Z)-eicosatrienoate => 8-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate + H2O"}
{"X":52320,"RHEA_ID":61136,"compounds":"(2R,3R)-dihydroquercetin + 2-oxoglutarate + O2 = CO2 + H(+) + H2O + quercetin + succinate"}
{"X":52321,"RHEA_ID":61137,"DIRECTION":"LR","MASTER_ID":61136,"metacyc":"RXN-527","compounds":"(2R,3R)-dihydroquercetin + 2-oxoglutarate + O2 => CO2 + H(+) + H2O + quercetin + succinate"}
{"X":52322,"RHEA_ID":61138,"compounds":"CO2 + H(+) + H2O + quercetin + succinate => (2R,3R)-dihydroquercetin + 2-oxoglutarate + O2"}
{"X":52323,"RHEA_ID":50902,"compounds":"(10,11S,12R)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoate => 10-hydroxy-(11S,12S)-epoxy- (5Z,8Z,14Z)-eicosatrienoate + H2O"}
{"X":52324,"RHEA_ID":61140,"compounds":"(2R,3R)-dihydromyricetin + 2-oxoglutarate + O2 = CO2 + H(+) + H2O + myricetin + succinate"}
{"X":52325,"RHEA_ID":54210,"compounds":"2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O => 2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2"}
{"X":52326,"RHEA_ID":61142,"compounds":"CO2 + H(+) + H2O + myricetin + succinate => (2R,3R)-dihydromyricetin + 2-oxoglutarate + O2"}
{"X":52327,"RHEA_ID":50906,"compounds":"H(+) + N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine => L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine"}
{"X":52328,"RHEA_ID":61144,"compounds":"myricetin + UDP-beta-L-rhamnose = H(+) + myricetin 3-O-alpha-L-rhamnoside + UDP"}
{"X":52329,"RHEA_ID":61145,"compounds":"myricetin + UDP-beta-L-rhamnose => H(+) + myricetin 3-O-alpha-L-rhamnoside + UDP"}
{"X":52330,"RHEA_ID":61146,"compounds":"H(+) + myricetin 3-O-alpha-L-rhamnoside + UDP => myricetin + UDP-beta-L-rhamnose"}
{"X":52331,"RHEA_ID":50910,"compounds":"A + a 3-demethylubiquinol + H2O => a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2"}
{"X":52332,"RHEA_ID":61148,"compounds":"myricetin 3-O-alpha-L-rhamnoside + UDP-alpha-D-glucose = H(+) + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] + UDP"}
{"X":52333,"RHEA_ID":54218,"compounds":"2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O => 2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2"}
{"X":52334,"RHEA_ID":50913,"DIRECTION":"LR","MASTER_ID":50912,"metacyc":"RXN-18015","compounds":"4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-L-ribitol => 4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)"}
{"X":52335,"RHEA_ID":50914,"compounds":"4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+) => 4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-L-ribitol"}
{"X":52336,"RHEA_ID":57565,"DIRECTION":"LR","MASTER_ID":57564,"metacyc":"RXN-19644","compounds":"(+)-cis-trans-nepetalactol + O2 + reduced [NADPH--hemoprotein reductase] => 7-deoxyloganetic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52337,"RHEA_ID":54222,"DIRECTION":"RL","MASTER_ID":54220,"metacyc":"RXN-10665","compounds":"all-trans-neurosporene + H2O => 1-hydroxy-all-trans-1,2-dihydro-neurosporene"}
{"X":52338,"RHEA_ID":61154,"compounds":"CoA + myricetin 3-O-[(6-O-(E)-caffeoyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside] => (E)-caffeoyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside]"}
{"X":52339,"RHEA_ID":50918,"compounds":"AMP + an aldehyde + diphosphate + NADP(+) => a carboxylate + ATP + H(+) + NADPH"}
{"X":52340,"RHEA_ID":61156,"compounds":"3'-dephospho-CoA + GTP = CoA + GDP + H(+)"}
{"X":52341,"RHEA_ID":61157,"compounds":"3'-dephospho-CoA + GTP => CoA + GDP + H(+)"}
{"X":52342,"RHEA_ID":50921,"compounds":"2 2-iminio-3-(indol-3-yl)propanoate + H2O2 => chromopyrrolate + H(+) + 2 H2O + NH4(+)"}
{"X":52343,"RHEA_ID":50922,"compounds":"chromopyrrolate + H(+) + 2 H2O + NH4(+) => 2 2-iminio-3-(indol-3-yl)propanoate + H2O2"}
{"X":52344,"RHEA_ID":61160,"compounds":"quercetin + UDP-beta-L-rhamnose = H(+) + quercitrin + UDP"}
{"X":52345,"RHEA_ID":54230,"compounds":"2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine => 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine"}
{"X":52346,"RHEA_ID":61162,"compounds":"H(+) + quercitrin + UDP => quercetin + UDP-beta-L-rhamnose"}
{"X":52347,"RHEA_ID":50926,"compounds":"(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2"}
{"X":52348,"RHEA_ID":50927,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 <=> (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate"}
{"X":52349,"RHEA_ID":61165,"DIRECTION":"LR","MASTER_ID":61164,"metacyc":"RXN1F-474","compounds":"kaempferol + UDP-beta-L-rhamnose => H(+) + kaempferol 3-O-alpha-L-rhamnoside + UDP"}
{"X":52350,"RHEA_ID":62467,"compounds":"1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O <=> 2-nonadioyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":52351,"RHEA_ID":50930,"compounds":"(14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2"}
{"X":52352,"RHEA_ID":61168,"compounds":"quercetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose = H(+) + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP"}
{"X":52353,"RHEA_ID":61169,"DIRECTION":"LR","MASTER_ID":61168,"metacyc":"RXN-14000","compounds":"quercetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose => H(+) + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP"}
{"X":52354,"RHEA_ID":50933,"compounds":"(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 => (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate"}
{"X":52355,"RHEA_ID":50934,"compounds":"(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate => (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2"}
{"X":52356,"RHEA_ID":61172,"compounds":"myricetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose = H(+) + myricetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP"}
{"X":52357,"RHEA_ID":61173,"compounds":"myricetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose => H(+) + myricetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP"}
{"X":52358,"RHEA_ID":57587,"compounds":"a flavanone + O2 + reduced [NADPH--hemoprotein reductase] <=> a 2-hydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52359,"RHEA_ID":50938,"compounds":"acetoacetyl-CoA + L-glutamate => 2-oxoglutarate + 3-aminobutanoyl-CoA"}
{"X":52360,"RHEA_ID":57589,"DIRECTION":"LR","MASTER_ID":57588,"metacyc":"RXN-14069","compounds":"(S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] => (2S)-2-hydroxynaringenin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52361,"RHEA_ID":61177,"compounds":"(E)-caffeoyl-CoA + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside => CoA + H(+) + quercetin 3-O-[(6-O-[(E)-caffeoyl]-beta-D-glucosyl)-(1->2)-beta-D-glucoside]"}
{"X":52362,"RHEA_ID":50941,"compounds":"L-leucyl-tRNA(Leu) + L-phenylalanyl-tRNA(Phe) => cyclo(L-phenylalanyl-L-leucyl) + H(+) + tRNA(Leu) + tRNA(Phe)"}
{"X":52363,"RHEA_ID":50942,"compounds":"cyclo(L-phenylalanyl-L-leucyl) + H(+) + tRNA(Leu) + tRNA(Phe) => L-leucyl-tRNA(Leu) + L-phenylalanyl-tRNA(Phe)"}
{"X":52364,"RHEA_ID":61180,"compounds":"quercetin + UDP-alpha-D-glucose = H(+) + quercetin 3-O-beta-D-glucoside + UDP"}
{"X":52365,"RHEA_ID":61181,"DIRECTION":"LR","MASTER_ID":61180,"metacyc":"RXN1F-462","compounds":"quercetin + UDP-alpha-D-glucose => H(+) + quercetin 3-O-beta-D-glucoside + UDP"}
{"X":52366,"RHEA_ID":61182,"compounds":"H(+) + quercetin 3-O-beta-D-glucoside + UDP => quercetin + UDP-alpha-D-glucose"}
{"X":52367,"RHEA_ID":50946,"compounds":"H(+) + NADH + trans-cinnamate => 3-phenylpropanoate + NAD(+)"}
{"X":52368,"RHEA_ID":62509,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine"}
{"X":52369,"RHEA_ID":61185,"DIRECTION":"LR","MASTER_ID":61184,"metacyc":"RXNQT-4162","compounds":"quercitrin + UDP-beta-L-rhamnose => H(+) + quercetin 3,7-bis-O-alpha-L-rhamnoside + UDP"}
{"X":52370,"RHEA_ID":61186,"compounds":"H(+) + quercetin 3,7-bis-O-alpha-L-rhamnoside + UDP => quercitrin + UDP-beta-L-rhamnose"}
{"X":52371,"RHEA_ID":50950,"compounds":"a 2'-deoxyuridine in a single-stranded DNA + NH4(+) => a 2'-deoxycytidine in a single-stranded DNA + H(+) + H2O"}
{"X":52372,"RHEA_ID":50951,"DIRECTION":"BI","MASTER_ID":50948,"metacyc":"RXN-13993","compounds":"a 2'-deoxycytidine in a single-stranded DNA + H(+) + H2O <=> a 2'-deoxyuridine in a single-stranded DNA + NH4(+)"}
{"X":52373,"RHEA_ID":61189,"DIRECTION":"LR","MASTER_ID":61188,"metacyc":"RXNQT-4161","compounds":"quercetin 3-O-beta-D-glucoside + UDP-beta-L-rhamnose => H(+) + quercetin 3-O-beta-D-glucoside-7-O-alpha-L-rhamnoside + UDP"}
{"X":52374,"RHEA_ID":61190,"compounds":"H(+) + quercetin 3-O-beta-D-glucoside-7-O-alpha-L-rhamnoside + UDP => quercetin 3-O-beta-D-glucoside + UDP-beta-L-rhamnose"}
{"X":52375,"RHEA_ID":50954,"compounds":"A + CO2 + 2 H2O + monodechloroaminopyrrolnitrin => 7-chloro-L-tryptophan + AH2 + O2"}
{"X":52376,"RHEA_ID":54261,"compounds":"2-oxoglutarate + L-asparaginyl-[protein] + O2 => (3S)-3-hydroxy-L-asparaginyl-[protein] + CO2 + succinate"}
{"X":52377,"RHEA_ID":61193,"compounds":"(E)-4-coumaroyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] => CoA + H(+) + myricetin 3-O-[(6-O-(E)-4-coumaroyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]"}
{"X":52378,"RHEA_ID":50957,"DIRECTION":"LR","MASTER_ID":50956,"metacyc":"RXN-13999","compounds":"cytidine(32) in tRNA(Ser) + S-adenosyl-L-methionine => H(+) + N(3)-methylcytidine(32) in tRNA(Ser) + S-adenosyl-L-homocysteine"}
{"X":52379,"RHEA_ID":50958,"compounds":"H(+) + N(3)-methylcytidine(32) in tRNA(Ser) + S-adenosyl-L-homocysteine => cytidine(32) in tRNA(Ser) + S-adenosyl-L-methionine"}
{"X":52380,"RHEA_ID":61196,"compounds":"(E)-feruloyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] = CoA + H(+) + myricetin 3-O-[(6-O-[(E)-feruloyl]-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]"}
{"X":52381,"RHEA_ID":54266,"compounds":"(3S)-3-hydroxy-L-histidyl-[ankyrin-repeat domain protein] + CO2 + succinate => 2-oxoglutarate + L-histidyl-[ankyrin-repeat domain protein] + O2"}
{"X":52382,"RHEA_ID":61197,"compounds":"(E)-feruloyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] => CoA + H(+) + myricetin 3-O-[(6-O-[(E)-feruloyl]-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]"}
{"X":52383,"RHEA_ID":61199,"compounds":"(E)-feruloyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] <=> CoA + H(+) + myricetin 3-O-[(6-O-[(E)-feruloyl]-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]"}
{"X":52384,"RHEA_ID":61200,"compounds":"acetyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] = CoA + myricetin 3-O-[(6-O-acetyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]"}
{"X":52385,"RHEA_ID":50964,"DIRECTION":"UN","MASTER_ID":50964,"ec":"3.5.4.35","compounds":"cytidine(8) in tRNA + H(+) + H2O = NH4(+) + uridine(8) in tRNA"}
{"X":52386,"RHEA_ID":61202,"compounds":"CoA + myricetin 3-O-[(6-O-acetyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside] => acetyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside]"}
{"X":52387,"RHEA_ID":61203,"compounds":"acetyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] <=> CoA + myricetin 3-O-[(6-O-acetyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]"}
{"X":52388,"RHEA_ID":61204,"compounds":"L-arginyl-[protein] + L-cysteinyl-[protein] + methylglyoxal = H(+) + 2 H2O + N(5)-[4-(S-L-cysteinyl-[protein])-5-methyl-1H-imidazol-2-yl]-L-ornithinyl-[protein]"}
{"X":52389,"RHEA_ID":50968,"DIRECTION":"UN","MASTER_ID":50968,"ec":"3.5.4.34","compounds":"adenosine(37) in tRNA(Ala) + H(+) + H2O = inosine(37) in tRNA(Ala) + NH4(+)"}
{"X":52390,"RHEA_ID":61206,"compounds":"H(+) + 2 H2O + N(5)-[4-(S-L-cysteinyl-[protein])-5-methyl-1H-imidazol-2-yl]-L-ornithinyl-[protein] => L-arginyl-[protein] + L-cysteinyl-[protein] + methylglyoxal"}
{"X":52391,"RHEA_ID":50970,"compounds":"inosine(37) in tRNA(Ala) + NH4(+) => adenosine(37) in tRNA(Ala) + H(+) + H2O"}
{"X":52392,"RHEA_ID":50972,"compounds":"(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate"}
{"X":52393,"RHEA_ID":61210,"compounds":"H(+) + nitrite + S-(guanosine 3',5'-cyclic phosphate)-L-cysteinyl-[protein] => 8-nitro-cGMP + L-cysteinyl-[protein]"}
{"X":52394,"RHEA_ID":61211,"compounds":"8-nitro-cGMP + L-cysteinyl-[protein] <=> H(+) + nitrite + S-(guanosine 3',5'-cyclic phosphate)-L-cysteinyl-[protein]"}
{"X":52395,"RHEA_ID":61212,"compounds":"myricetin + UDP-alpha-D-glucose = H(+) + myricetin 3-O-beta-D-glucoside + UDP"}
{"X":52396,"RHEA_ID":50976,"compounds":"prostaglandin D2(out) = prostaglandin D2(in)"}
{"X":52397,"RHEA_ID":61214,"compounds":"H(+) + myricetin 3-O-beta-D-glucoside + UDP => myricetin + UDP-alpha-D-glucose"}
{"X":52398,"RHEA_ID":61215,"compounds":"myricetin + UDP-alpha-D-glucose <=> H(+) + myricetin 3-O-beta-D-glucoside + UDP"}
{"X":52399,"RHEA_ID":61216,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + 1D-myo-inositol 3-phosphate = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)"}
{"X":52400,"RHEA_ID":50980,"compounds":"prostaglandin E1(out) = prostaglandin E1(in)"}
{"X":52401,"RHEA_ID":50981,"compounds":"prostaglandin E1(out) => prostaglandin E1(in)"}
{"X":52402,"RHEA_ID":61219,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + 1D-myo-inositol 3-phosphate <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)"}
{"X":52403,"RHEA_ID":61220,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-CDP + 1D-myo-inositol 3-phosphate = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)"}
{"X":52404,"RHEA_ID":50984,"compounds":"prostaglandin E2(out) = prostaglandin E2(in)"}
{"X":52405,"RHEA_ID":57635,"compounds":"ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + ML-236A carboxylate + oxidized [NADPH--hemoprotein reductase]"}
{"X":52406,"RHEA_ID":61223,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-CDP + 1D-myo-inositol 3-phosphate <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)"}
{"X":52407,"RHEA_ID":61224,"compounds":"H2O + L-asparagine + O2 = 2-oxosuccinamate + H2O2 + NH4(+)"}
{"X":52408,"RHEA_ID":50988,"compounds":"prostaglandin F2alpha(out) = prostaglandin F2alpha(in)"}
{"X":52409,"RHEA_ID":50989,"compounds":"prostaglandin F2alpha(out) => prostaglandin F2alpha(in)"}
{"X":52410,"RHEA_ID":50990,"compounds":"prostaglandin F2alpha(in) => prostaglandin F2alpha(out)"}
{"X":52411,"RHEA_ID":61228,"compounds":"H2O + L-histidine + O2 = 3-(imidazol-5-yl)pyruvate + H2O2 + NH4(+)"}
{"X":52412,"RHEA_ID":50992,"compounds":"thromboxane B2(out) = thromboxane B2(in)"}
{"X":52413,"RHEA_ID":61230,"compounds":"3-(imidazol-5-yl)pyruvate + H2O2 + NH4(+) => H2O + L-histidine + O2"}
{"X":52414,"RHEA_ID":50994,"compounds":"thromboxane B2(in) => thromboxane B2(out)"}
{"X":52415,"RHEA_ID":50995,"compounds":"thromboxane B2(out) <=> thromboxane B2(in)"}
{"X":52416,"RHEA_ID":54302,"compounds":"n adenosine 3',5'-bisphosphate + chondroitin 4',6'-disulfate + n H(+) => n 3'-phosphoadenylyl sulfate + chondroitin 4'-sulfate"}
{"X":52417,"RHEA_ID":50997,"DIRECTION":"LR","MASTER_ID":50996,"metacyc":"2.1.1.127-RXN","compounds":"[ribulose-1,5-bisphosphate carboxylase]-L-lysine + 3 S-adenosyl-L-methionine => [ribulose-1,5-bisphosphate carboxylase]-N(6),N(6),N(6)-trimethyl-L-lysine + 3 H(+) + 3 S-adenosyl-L-homocysteine"}
{"X":52418,"RHEA_ID":57652,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GA1 = CMP + ganglioside GM1alpha + H(+)"}
{"X":52419,"RHEA_ID":57653,"compounds":"CMP-N-acetyl-beta-neuraminate + ganglioside GA1 => CMP + ganglioside GM1alpha + H(+)"}
{"X":52420,"RHEA_ID":54306,"compounds":"n adenosine 3',5'-bisphosphate + dermatan 4',6'-disulfate + n H(+) => n 3'-phosphoadenylyl sulfate + dermatan 4'-sulfate"}
{"X":52421,"RHEA_ID":51001,"DIRECTION":"LR","MASTER_ID":51000,"metacyc":"RXN-13588","compounds":"[fructose-bisphosphate aldolase]-L-lysine + 3 S-adenosyl-L-methionine => [fructose-bisphosphate aldolase]-N(6),N(6),N(6)-trimethyl-L-lysine + 3 H(+) + 3 S-adenosyl-L-homocysteine"}
{"X":52422,"RHEA_ID":51002,"compounds":"[fructose-bisphosphate aldolase]-N(6),N(6),N(6)-trimethyl-L-lysine + 3 H(+) + 3 S-adenosyl-L-homocysteine => [fructose-bisphosphate aldolase]-L-lysine + 3 S-adenosyl-L-methionine"}
{"X":52423,"RHEA_ID":61240,"compounds":"H2O + L-phenylalanine + O2 = 3-phenylpyruvate + H2O2 + NH4(+)"}
{"X":52424,"RHEA_ID":54310,"compounds":"H(+) + N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-homocysteine => pseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine"}
{"X":52425,"RHEA_ID":61242,"compounds":"3-phenylpyruvate + H2O2 + NH4(+) => H2O + L-phenylalanine + O2"}
{"X":52426,"RHEA_ID":54320,"DIRECTION":"UN","MASTER_ID":54320,"ec":"1.14.19.20","compounds":"2 [Fe(II)-cytochrome b5] + a Delta(7)-sterol + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a Delta(5),Delta(7)-sterol + 2 H2O"}
{"X":52427,"RHEA_ID":61244,"compounds":"H2O + L-tryptophan + O2 = H2O2 + indole-3-pyruvate + NH4(+)"}
{"X":52428,"RHEA_ID":54322,"compounds":"2 [Fe(III)-cytochrome b5] + a Delta(5),Delta(7)-sterol + 2 H2O => 2 [Fe(II)-cytochrome b5] + a Delta(7)-sterol + 2 H(+) + O2"}
{"X":52429,"RHEA_ID":61246,"compounds":"H2O2 + indole-3-pyruvate + NH4(+) => H2O + L-tryptophan + O2"}
{"X":52430,"RHEA_ID":51009,"DIRECTION":"LR","MASTER_ID":51008,"metacyc":"RXN-2861","compounds":"2 [Fe(III)cytochrome cL] + methanol => 2 [Fe(II)cytochrome cL] + formaldehyde + 2 H(+)"}
{"X":52431,"RHEA_ID":61248,"compounds":"H2O + L-tyrosine + O2 = 3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+)"}
{"X":52432,"RHEA_ID":54326,"compounds":"a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 16 H(+) + 16 reduced [2Fe-2S]-[ferredoxin] => a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid + 16 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":52433,"RHEA_ID":51012,"compounds":"a monoacyl-sn-glycero-3-phosphocholine + H2O = a monoacylglycerol + H(+) + phosphocholine"}
{"X":52434,"RHEA_ID":54328,"compounds":"2 H(+) + hexadecanoyl-[ACP] + 2 NADPH = hexadecan-1-ol + holo-[ACP] + 2 NADP(+)"}
{"X":52435,"RHEA_ID":61252,"compounds":"H2O + L-valine + O2 = 3-methyl-2-oxobutanoate + H2O2 + NH4(+)"}
{"X":52436,"RHEA_ID":54330,"compounds":"hexadecan-1-ol + holo-[ACP] + 2 NADP(+) => 2 H(+) + hexadecanoyl-[ACP] + 2 NADPH"}
{"X":52437,"RHEA_ID":61254,"compounds":"3-methyl-2-oxobutanoate + H2O2 + NH4(+) => H2O + L-valine + O2"}
{"X":52438,"RHEA_ID":51017,"DIRECTION":"LR","MASTER_ID":51016,"metacyc":"RXN-18378","compounds":"7,8-dihydroneopterin 3'-phosphate => 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde phosphate"}
{"X":52439,"RHEA_ID":57673,"DIRECTION":"LR","MASTER_ID":57672,"metacyc":"RXN-4802","compounds":"(+)-5-epi-aristolochene + O2 + reduced [NADPH--hemoprotein reductase] => 2beta-hydroxy-5-epi-aristolochene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52440,"RHEA_ID":54334,"compounds":"1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H(+) => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + CDP-choline"}
{"X":52441,"RHEA_ID":61258,"compounds":"3-mercaptopyruvate + H2O2 + NH4(+) => H2O + L-cysteine + O2"}
{"X":52442,"RHEA_ID":51021,"compounds":"2 [Fe(III)cytochrome c] + a primary alcohol => 2 [Fe(II)cytochrome c] + an aldehyde + 2 H(+)"}
{"X":52443,"RHEA_ID":61259,"compounds":"H2O + L-cysteine + O2 <=> 3-mercaptopyruvate + H2O2 + NH4(+)"}
{"X":52444,"RHEA_ID":54338,"compounds":"1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+) => 1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-choline"}
{"X":52445,"RHEA_ID":51024,"compounds":"H(+) + NADH + O2 + toluene-4-sulfonate = 4-(hydroxymethyl)benzenesulfonate + H2O + NAD(+)"}
{"X":52446,"RHEA_ID":51025,"DIRECTION":"LR","MASTER_ID":51024,"metacyc":"TSMOS-RXN","compounds":"H(+) + NADH + O2 + toluene-4-sulfonate => 4-(hydroxymethyl)benzenesulfonate + H2O + NAD(+)"}
{"X":52447,"RHEA_ID":57681,"DIRECTION":"LR","MASTER_ID":57680,"metacyc":"RXN-19646","compounds":"a flavanone + O2 + reduced [NADPH--hemoprotein reductase] => a flavone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52448,"RHEA_ID":54342,"compounds":"1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+) => 1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-ethanolamine"}
{"X":52449,"RHEA_ID":61266,"compounds":"H2O2 + NH4(+) + pyruvate => H2O + L-alanine + O2"}
{"X":52450,"RHEA_ID":51029,"compounds":"2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 => 7-chloroindole-3-pyruvate imine dimer + 2 H2O"}
{"X":52451,"RHEA_ID":57689,"compounds":"apo-[corrinoid adenosyltransferase] + cob(II)inamide => cob(II)inamide--[corrinoid adenosyltransferase]"}
{"X":52452,"RHEA_ID":54346,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CMP + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline"}
{"X":52453,"RHEA_ID":61270,"compounds":"2-oxohexanoate + H2O2 + NH4(+) => H2O + L-2-aminohexanoate + O2"}
{"X":52454,"RHEA_ID":51033,"compounds":"7-chloroindole-3-pyruvate imine dimer => dichlorochromopyrrolate + H(+) + NH4(+)"}
{"X":52455,"RHEA_ID":61272,"compounds":"H2O + L-2-aminopentanoate + O2 = 2-oxopentanoate + H2O2 + NH4(+)"}
{"X":52456,"RHEA_ID":51035,"compounds":"7-chloroindole-3-pyruvate imine dimer <=> dichlorochromopyrrolate + H(+) + NH4(+)"}
{"X":52457,"RHEA_ID":61274,"compounds":"2-oxopentanoate + H2O2 + NH4(+) => H2O + L-2-aminopentanoate + O2"}
{"X":52458,"RHEA_ID":51037,"DIRECTION":"LR","MASTER_ID":51036,"metacyc":"RXN-18167","compounds":"2 2-iminio-3-(indol-3-yl)propanoate + H2O2 => 2 H2O + indole-3-pyruvate imine dimer"}
{"X":52459,"RHEA_ID":54353,"compounds":"1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CMP + H(+)"}
{"X":52460,"RHEA_ID":51039,"compounds":"2 2-iminio-3-(indol-3-yl)propanoate + H2O2 <=> 2 H2O + indole-3-pyruvate imine dimer"}
{"X":52461,"RHEA_ID":54355,"compounds":"1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline <=> 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CMP + H(+)"}
{"X":52462,"RHEA_ID":51041,"DIRECTION":"LR","MASTER_ID":51040,"metacyc":"RXN-18168","compounds":"indole-3-pyruvate imine dimer => chromopyrrolate + H(+) + NH4(+)"}
{"X":52463,"RHEA_ID":61280,"compounds":"4-aminobutanoate + H2O + O2 = H2O2 + NH4(+) + succinate semialdehyde"}
{"X":52464,"RHEA_ID":51043,"compounds":"indole-3-pyruvate imine dimer <=> chromopyrrolate + H(+) + NH4(+)"}
{"X":52465,"RHEA_ID":54359,"compounds":"3-methyl-2-oxobutanoate + H(+) <=> 2-methylpropanal + CO2"}
{"X":52466,"RHEA_ID":51045,"compounds":"indole-3-pyruvate imine dimer => CO2 + NH4(+) + protodeoxyviolaceinate"}
{"X":52467,"RHEA_ID":61284,"compounds":"H2O + L-cystine + O2 = (2R)-2-amino-2-carboxylatoethyl-disulfanyl-oxopropanoate + H2O2 + NH4(+)"}
{"X":52468,"RHEA_ID":51047,"compounds":"indole-3-pyruvate imine dimer <=> CO2 + NH4(+) + protodeoxyviolaceinate"}
{"X":52469,"RHEA_ID":54363,"compounds":"4-methyl-2-oxopentanoate + H(+) <=> 3-methylbutanal + CO2"}
{"X":52470,"RHEA_ID":51049,"DIRECTION":"LR","MASTER_ID":51048,"metacyc":"RXN-12124","compounds":"5alpha-androstan-3,17-dione + A => AH2 + androst-4-ene-3,17-dione"}
{"X":52471,"RHEA_ID":54365,"DIRECTION":"LR","MASTER_ID":54364,"metacyc":"RXN3O-470","compounds":"2 acetaldehyde => acetoin"}
{"X":52472,"RHEA_ID":61289,"compounds":"5-deoxy-alpha-D-ribose + ATP => 5-deoxy-alpha-D-ribose 1-phosphate + ADP + H(+)"}
{"X":52473,"RHEA_ID":57711,"compounds":"(E)-coniferaldehyde + UDP-alpha-D-glucose <=> 4-O-(beta-D-glucosyl)-4-trans-coniferyl aldehyde + H(+) + UDP"}
{"X":52474,"RHEA_ID":61291,"compounds":"5-deoxy-alpha-D-ribose + ATP <=> 5-deoxy-alpha-D-ribose 1-phosphate + ADP + H(+)"}
{"X":52475,"RHEA_ID":61292,"compounds":"(R)-pantoate + NAD(+) = 2-dehydropantoate + H(+) + NADH"}
{"X":52476,"RHEA_ID":51055,"compounds":"5alpha-androstan-3,17-dione + A <=> 5alpha-androst-1-ene-3,17-dione + AH2"}
{"X":52477,"RHEA_ID":51056,"DIRECTION":"UN","MASTER_ID":51056,"ec":"1.3.99.4","compounds":"A + androst-4-ene-3,17-dione = AH2 + androsta-1,4-diene-3,17-dione"}
{"X":52478,"RHEA_ID":51057,"DIRECTION":"LR","MASTER_ID":51056,"metacyc":"RXN-12714","compounds":"A + androst-4-ene-3,17-dione => AH2 + androsta-1,4-diene-3,17-dione"}
{"X":52479,"RHEA_ID":54373,"DIRECTION":"LR","MASTER_ID":54372,"metacyc":"RXN-18887","compounds":"(2E,6E)-farnesyl diphosphate + H2O => (+)-(2S,3R,9R)-pristinol + diphosphate"}
{"X":52480,"RHEA_ID":61297,"compounds":"5-deoxy-alpha-D-ribose 1-phosphate => 5-deoxy-D-ribulose 1-phosphate"}
{"X":52481,"RHEA_ID":57719,"DIRECTION":"BI","MASTER_ID":57716,"metacyc":"RXN-19659","compounds":"hydrogencarbonate + NH4(+) <=> carbamate + H(+) + H2O"}
{"X":52482,"RHEA_ID":61298,"compounds":"5-deoxy-D-ribulose 1-phosphate => 5-deoxy-alpha-D-ribose 1-phosphate"}
{"X":52483,"RHEA_ID":54377,"DIRECTION":"LR","MASTER_ID":54376,"metacyc":"RXN-18888","compounds":"(+)-copalyl diphosphate + H2O => diphosphate + nezukol"}
{"X":52484,"RHEA_ID":51063,"compounds":"5alpha-androst-1-ene-3,17-dione + A <=> AH2 + androsta-1,4-diene-3,17-dione"}
{"X":52485,"RHEA_ID":61301,"compounds":"5-deoxy-D-ribulose 1-phosphate => acetaldehyde + dihydroxyacetone phosphate"}
{"X":52486,"RHEA_ID":51065,"DIRECTION":"LR","MASTER_ID":51064,"reactome":"R-HSA-176588.2","compounds":"3'-phosphoadenylyl sulfate + lithocholate => adenosine 3',5'-bisphosphate + H(+) + lithocholate sulfate"}
{"X":52487,"RHEA_ID":61304,"compounds":"N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + UDP-alpha-D-glucose = H(+) + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + UDP"}
{"X":52488,"RHEA_ID":61305,"compounds":"N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + UDP-alpha-D-glucose => H(+) + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + UDP"}
{"X":52489,"RHEA_ID":55486,"compounds":"ent-cassa-12,15-dien-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":52490,"RHEA_ID":51069,"compounds":"(2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + pyruvate => (3S,5R,10R,12S,14S,15R,16R)-3,5,10,14,15-pentahydroxy-12,16-dimethylicosan-2-one + L-alanine"}
{"X":52491,"RHEA_ID":61308,"compounds":"(+)-(R)-germacrene A + O2 + reduced [NADPH--hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52492,"RHEA_ID":57730,"compounds":"CO2 + itaconate => H(+) + trans-aconitate"}
{"X":52493,"RHEA_ID":51072,"DIRECTION":"UN","MASTER_ID":51072,"ec":"2.8.2.22","compounds":"a phenol + a phenyl sulfate = a phenol + a phenyl sulfate"}
{"X":52494,"RHEA_ID":51073,"compounds":"a phenol + a phenyl sulfate => a phenol + a phenyl sulfate"}
{"X":52495,"RHEA_ID":57733,"compounds":"A + all-trans-7,8-dihydroretinol => AH2 + all-trans-retinol"}
{"X":52496,"RHEA_ID":57734,"compounds":"AH2 + all-trans-retinol => A + all-trans-7,8-dihydroretinol"}
{"X":52497,"RHEA_ID":51076,"compounds":"2-hydroxy-17beta-estradiol + 3'-phosphoadenylyl sulfate = 2-hydroxy-17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)"}
{"X":52498,"RHEA_ID":51077,"compounds":"2-hydroxy-17beta-estradiol + 3'-phosphoadenylyl sulfate => 2-hydroxy-17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)"}
{"X":52499,"RHEA_ID":61316,"compounds":"germacra-1(10),4,11(13)-trien-12-al + O2 + reduced [NADPH--hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52500,"RHEA_ID":51079,"compounds":"2-hydroxy-17beta-estradiol + 3'-phosphoadenylyl sulfate <=> 2-hydroxy-17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)"}
{"X":52501,"RHEA_ID":51080,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19,20-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52502,"RHEA_ID":51081,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 19,20-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52503,"RHEA_ID":61320,"compounds":"(+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + parthenolide"}
{"X":52504,"RHEA_ID":61321,"compounds":"(+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + parthenolide"}
{"X":52505,"RHEA_ID":51084,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 16,17-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52506,"RHEA_ID":51085,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 16,17-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52507,"RHEA_ID":61324,"compounds":"(+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase] = 3beta-hydroxycostunolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52508,"RHEA_ID":61325,"compounds":"(+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase] => 3beta-hydroxycostunolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52509,"RHEA_ID":51088,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 13,14-epoxy-(4Z,7Z,10Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52510,"RHEA_ID":51089,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 13,14-epoxy-(4Z,7Z,10Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52511,"RHEA_ID":61328,"compounds":"O2 + parthenolide + reduced [NADPH--hemoprotein reductase] = 3beta-hydroxyparthenolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52512,"RHEA_ID":61329,"compounds":"O2 + parthenolide + reduced [NADPH--hemoprotein reductase] => 3beta-hydroxyparthenolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52513,"RHEA_ID":51092,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 10,11-epoxy-(4Z,7Z,13Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52514,"RHEA_ID":51093,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 10,11-epoxy-(4Z,7Z,13Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52515,"RHEA_ID":57753,"DIRECTION":"LR","MASTER_ID":57752,"metacyc":"RXN-17222","compounds":"2 (S)-methylmalonyl-CoA + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH => C34-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)"}
{"X":52516,"RHEA_ID":57754,"compounds":"C34-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+) => 2 (S)-methylmalonyl-CoA + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH"}
{"X":52517,"RHEA_ID":51096,"compounds":"(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19,20-epoxy-(7Z,10Z,13Z,16Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52518,"RHEA_ID":51097,"compounds":"(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 19,20-epoxy-(7Z,10Z,13Z,16Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52519,"RHEA_ID":57757,"DIRECTION":"LR","MASTER_ID":57756,"metacyc":"RXN-17215","compounds":"2 (S)-methylmalonyl-CoA + 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH => C35-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)"}
{"X":52520,"RHEA_ID":61337,"compounds":"ATP + H2O + protoporphyrin IX(in) => ADP + H(+) + phosphate + protoporphyrin IX(out)"}
{"X":52521,"RHEA_ID":62707,"compounds":"glycyldehydrophenylalanine + H2O <=> 2,3-didehydrophenylalanine + glycine"}
{"X":52522,"RHEA_ID":51101,"compounds":"(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 16,17-epoxy-(7Z,10Z,13Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52523,"RHEA_ID":61340,"DIRECTION":"UN","MASTER_ID":61340,"ec":"4.1.1.94","compounds":"(S)-methylmalonyl-CoA + H(+) = CO2 + propanoyl-CoA"}
{"X":52524,"RHEA_ID":57762,"compounds":"C37-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+) => 2 (S)-methylmalonyl-CoA + 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH"}
{"X":52525,"RHEA_ID":62711,"compounds":"(indol-3-yl)butanoate + UDP-alpha-D-glucose <=> 4-(indol-3-yl)butanoyl-beta-D-glucose + UDP"}
{"X":52526,"RHEA_ID":51105,"compounds":"(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 13,14-epoxy-(7Z,10Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52527,"RHEA_ID":61344,"compounds":"H2O + L-serine + O2 = 3-hydroxypyruvate + H2O2 + NH4(+)"}
{"X":52528,"RHEA_ID":51107,"compounds":"(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 13,14-epoxy-(7Z,10Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52529,"RHEA_ID":51108,"compounds":"(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 10,11-epoxy-(7Z,13Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52530,"RHEA_ID":51109,"compounds":"(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 10,11-epoxy-(7Z,13Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52531,"RHEA_ID":57769,"DIRECTION":"LR","MASTER_ID":57768,"metacyc":"RXN-8819","compounds":"2-nitrotoluene + NADH + O2 => 3-methylcatechol + NAD(+) + nitrite"}
{"X":52532,"RHEA_ID":57770,"compounds":"3-methylcatechol + NAD(+) + nitrite => 2-nitrotoluene + NADH + O2"}
{"X":52533,"RHEA_ID":51112,"compounds":"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52534,"RHEA_ID":51113,"compounds":"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52535,"RHEA_ID":54429,"compounds":"4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + H2O => ADP-D-ribose + H(+) + L-aspartyl-[protein]"}
{"X":52536,"RHEA_ID":54430,"compounds":"ADP-D-ribose + H(+) + L-aspartyl-[protein] => 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + H2O"}
{"X":52537,"RHEA_ID":51116,"DIRECTION":"UN","MASTER_ID":51116,"ec":"2.1.1.256","compounds":"guanosine(6) in tRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(6) in tRNA + S-adenosyl-L-homocysteine"}
{"X":52538,"RHEA_ID":51117,"DIRECTION":"LR","MASTER_ID":51116,"metacyc":"RXN-13195","compounds":"guanosine(6) in tRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(6) in tRNA + S-adenosyl-L-homocysteine"}
{"X":52539,"RHEA_ID":61356,"compounds":"ATP + H2O + methotrexate(in) = ADP + H(+) + methotrexate(out) + phosphate"}
{"X":52540,"RHEA_ID":54434,"compounds":"a 4-H-anthocyanidin with a 3-hydroxy group + CO2 + 2 H2O + succinate => 2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2"}
{"X":52541,"RHEA_ID":51120,"compounds":"(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 AH2 = (8S,15S)-dihydroxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 A + 2 H2O"}
{"X":52542,"RHEA_ID":55539,"compounds":"an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose <=> a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+)"}
{"X":52543,"RHEA_ID":61360,"compounds":"ATP + H2O + pheophorbide a(in) = ADP + H(+) + pheophorbide a(out) + phosphate"}
{"X":52544,"RHEA_ID":51123,"compounds":"(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 AH2 <=> (8S,15S)-dihydroxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 A + 2 H2O"}
{"X":52545,"RHEA_ID":51124,"compounds":"uridine in snRNA = pseudouridine in snRNA"}
{"X":52546,"RHEA_ID":61363,"compounds":"ATP + H2O + pheophorbide a(in) <=> ADP + H(+) + pheophorbide a(out) + phosphate"}
{"X":52547,"RHEA_ID":61364,"compounds":"3beta-sulfooxy-androst-5-en-17-one(in) + ATP + H2O = 3beta-sulfooxy-androst-5-en-17-one(out) + ADP + H(+) + phosphate"}
{"X":52548,"RHEA_ID":57786,"compounds":"4-nitrocatechol + H(+) + NAD(+) + nitrite => 1,4-dinitrobenzene + NADH + O2"}
{"X":52549,"RHEA_ID":51128,"DIRECTION":"UN","MASTER_ID":51128,"metacyc":"AMINE-DEHYDROGENASE-RXN","compounds":"A + an aliphatic amine + H2O = AH2 + an aldehyde + NH4(+)"}
{"X":52550,"RHEA_ID":61367,"compounds":"3beta-sulfooxy-androst-5-en-17-one(in) + ATP + H2O <=> 3beta-sulfooxy-androst-5-en-17-one(out) + ADP + H(+) + phosphate"}
{"X":52551,"RHEA_ID":61368,"compounds":"4-methylumbelliferone sulfate(in) + ATP + H2O = 4-methylumbelliferone sulfate(out) + ADP + H(+) + phosphate"}
{"X":52552,"RHEA_ID":54446,"DIRECTION":"RL","MASTER_ID":54444,"metacyc":"RXN-17678","compounds":"a (2R,3R)-dihydroflavonol + H(+) + NADPH => a (2R,3S,4S)-leucoanthocyanidin + NADP(+)"}
{"X":52553,"RHEA_ID":51132,"compounds":"a purine 2'-deoxyribonucleoside 5'-phosphate + H2O = 2-deoxy-D-ribose 5-phosphate + a purine nucleobase"}
{"X":52554,"RHEA_ID":61371,"compounds":"4-methylumbelliferone sulfate(in) + ATP + H2O <=> 4-methylumbelliferone sulfate(out) + ADP + H(+) + phosphate"}
{"X":52555,"RHEA_ID":61372,"compounds":"4-methylumbelliferone beta-D-glucuronate(in) + ATP + H2O = 4-methylumbelliferone beta-D-glucuronate(out) + ADP + H(+) + phosphate"}
{"X":52556,"RHEA_ID":61373,"compounds":"4-methylumbelliferone beta-D-glucuronate(in) + ATP + H2O => 4-methylumbelliferone beta-D-glucuronate(out) + ADP + H(+) + phosphate"}
{"X":52557,"RHEA_ID":51136,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 2 O2 = (10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E,19Z)-docosahexaenoate"}
{"X":52558,"RHEA_ID":61375,"compounds":"4-methylumbelliferone beta-D-glucuronate(in) + ATP + H2O <=> 4-methylumbelliferone beta-D-glucuronate(out) + ADP + H(+) + phosphate"}
{"X":52559,"RHEA_ID":61376,"compounds":"5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(in) + ATP + H2O = 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(out) + ADP + H(+) + phosphate"}
{"X":52560,"RHEA_ID":61377,"compounds":"5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(in) + ATP + H2O => 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(out) + ADP + H(+) + phosphate"}
{"X":52561,"RHEA_ID":51140,"compounds":"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + 2 O2 = (10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E)-docosapentaenoate"}
{"X":52562,"RHEA_ID":61379,"compounds":"5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(in) + ATP + H2O <=> 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(out) + ADP + H(+) + phosphate"}
{"X":52563,"RHEA_ID":61380,"compounds":"2,4-dinitrophenyl-S-glutathione(in) + ATP + H2O = 2,4-dinitrophenyl-S-glutathione(out) + ADP + H(+) + phosphate"}
{"X":52564,"RHEA_ID":61381,"compounds":"2,4-dinitrophenyl-S-glutathione(in) + ATP + H2O => 2,4-dinitrophenyl-S-glutathione(out) + ADP + H(+) + phosphate"}
{"X":52565,"RHEA_ID":51144,"compounds":"(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + 2 O2 = (10,17)-dihydroperoxy-(7Z,11Z,13Z,15E,19Z)-docosapentaenoate"}
{"X":52566,"RHEA_ID":61383,"compounds":"2,4-dinitrophenyl-S-glutathione(in) + ATP + H2O <=> 2,4-dinitrophenyl-S-glutathione(out) + ADP + H(+) + phosphate"}
{"X":52567,"RHEA_ID":61384,"compounds":"5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(in) + ATP + H2O = 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(out) + ADP + H(+) + phosphate"}
{"X":52568,"RHEA_ID":61385,"compounds":"5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(in) + ATP + H2O => 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(out) + ADP + H(+) + phosphate"}
{"X":52569,"RHEA_ID":51148,"DIRECTION":"UN","MASTER_ID":51148,"ec":"1.1.9.1","compounds":"a primary alcohol + 2 oxidized [azurin] = an aldehyde + 2 H(+) + 2 reduced [azurin]"}
{"X":52570,"RHEA_ID":61387,"compounds":"5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(in) + ATP + H2O <=> 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(out) + ADP + H(+) + phosphate"}
{"X":52571,"RHEA_ID":61388,"compounds":"ATP + biotin(in) + H2O = ADP + biotin(out) + H(+) + phosphate"}
{"X":52572,"RHEA_ID":61389,"compounds":"ATP + biotin(in) + H2O => ADP + biotin(out) + H(+) + phosphate"}
{"X":52573,"RHEA_ID":51152,"DIRECTION":"UN","MASTER_ID":51152,"ec":"1.8.3.7","compounds":"2 a thiol + L-cysteinyl-[sulfatase] + O2 = 3-oxo-L-alanyl-[sulfatase] + an organic disulfide + H(+) + H2O + hydrogen sulfide"}
{"X":52574,"RHEA_ID":61391,"compounds":"ATP + biotin(in) + H2O <=> ADP + biotin(out) + H(+) + phosphate"}
{"X":52575,"RHEA_ID":61392,"DIRECTION":"UN","MASTER_ID":61392,"ec":"2.7.1.172","metacyc":"RXN-12004","compounds":"ATP + N(6)-(D-psicosyl)-L-lysyl-[protein] = ADP + H(+) + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein]"}
{"X":52576,"RHEA_ID":54470,"compounds":"1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + octanoate => 1-octadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":52577,"RHEA_ID":51156,"compounds":"ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Gln)"}
{"X":52578,"RHEA_ID":61395,"compounds":"ATP + N(6)-(D-psicosyl)-L-lysyl-[protein] <=> ADP + H(+) + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein]"}
{"X":52579,"RHEA_ID":61396,"DIRECTION":"UN","MASTER_ID":61396,"ec":"2.7.1.172","compounds":"ATP + N(6)-(D-erythrulosyl)-L-lysyl-[protein] = ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein]"}
{"X":52580,"RHEA_ID":61397,"compounds":"ATP + N(6)-(D-erythrulosyl)-L-lysyl-[protein] => ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein]"}
{"X":52581,"RHEA_ID":54475,"compounds":"1-octadecanoyl-2-nonanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanoate"}
{"X":52582,"RHEA_ID":61399,"compounds":"ATP + N(6)-(D-erythrulosyl)-L-lysyl-[protein] <=> ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein]"}
{"X":52583,"RHEA_ID":61400,"compounds":"ATP + N(6)-(D-ribulosyl)-L-lysine = ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysine"}
{"X":52584,"RHEA_ID":54478,"compounds":"1-octadecanoyl-sn-glycero-3-phosphocholine + dodecanoate + H(+) => 1-octadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":52585,"RHEA_ID":51164,"compounds":"cytidine(61) in tRNA(Asp) + S-adenosyl-L-methionine = 5-methylcytidine(61) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine"}
{"X":52586,"RHEA_ID":61403,"compounds":"ATP + N(6)-(D-ribulosyl)-L-lysine <=> ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysine"}
{"X":52587,"RHEA_ID":61404,"compounds":"ATP + N-(D-ribulosyl)-cadaverine = ADP + H(+) + N-(3-O-phospho-D-ribulosyl)-cadaverine"}
{"X":52588,"RHEA_ID":61405,"compounds":"ATP + N-(D-ribulosyl)-cadaverine => ADP + H(+) + N-(3-O-phospho-D-ribulosyl)-cadaverine"}
{"X":52589,"RHEA_ID":54483,"compounds":"1-octadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate"}
{"X":52590,"RHEA_ID":51169,"DIRECTION":"LR","MASTER_ID":51168,"metacyc":"RXN-10908","compounds":"(R)-adrenaline + H2O + O2 => 3,4-dihydroxymandelaldehyde + H2O2 + methylamine"}
{"X":52591,"RHEA_ID":54485,"compounds":"1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphocholine => 1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine"}
{"X":52592,"RHEA_ID":54486,"compounds":"1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine => 1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphocholine"}
{"X":52593,"RHEA_ID":54487,"compounds":"1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphocholine <=> 1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine"}
{"X":52594,"RHEA_ID":51173,"compounds":"cytidine(62) in tRNA(Asp) + S-adenosyl-L-methionine => 5-methylcytidine(62) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine"}
{"X":52595,"RHEA_ID":54489,"compounds":"1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine => 1-heptanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-heptanoyl-sn-glycero-3-phosphocholine"}
{"X":52596,"RHEA_ID":54490,"compounds":"1-heptanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-heptanoyl-sn-glycero-3-phosphocholine => 1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":52597,"RHEA_ID":54491,"compounds":"1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine <=> 1-heptanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-heptanoyl-sn-glycero-3-phosphocholine"}
{"X":52598,"RHEA_ID":51177,"compounds":"cytidine(48) in tRNA(Asp) + S-adenosyl-L-methionine => 5-methylcytidine(48) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine"}
{"X":52599,"RHEA_ID":61416,"DIRECTION":"UN","MASTER_ID":61416,"ec":"5.5.1.34","compounds":"(S)-8-oxocitronellyl enol = cis-trans-nepetalactol"}
{"X":52600,"RHEA_ID":54494,"compounds":"1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphoethanolamine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine => 1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":52601,"RHEA_ID":54495,"compounds":"1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine <=> 1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphoethanolamine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine"}
{"X":52602,"RHEA_ID":51181,"compounds":"cytidine(49) in tRNA(Asp) + S-adenosyl-L-methionine => 5-methylcytidine(49) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine"}
{"X":52603,"RHEA_ID":57841,"DIRECTION":"LR","MASTER_ID":57840,"reactome":"R-HSA-6809561.2","compounds":"1D-myo-inositol 1,3-bisphosphate + H2O => 1D-myo-inositol 1-phosphate + phosphate"}
{"X":52604,"RHEA_ID":54498,"compounds":"diphosphate + ent-atiserene => ent-copalyl diphosphate"}
{"X":52605,"RHEA_ID":58954,"compounds":"(20S)-ginsenoside Rh1 + H(+) + UDP => (20S)-protopanaxatriol + UDP-alpha-D-glucose"}
{"X":52606,"RHEA_ID":51185,"compounds":"1-octadecanoyl-sn-glycero-3-phosphoserine + H2O => H(+) + octadecanoate + sn-glycero-3-phospho-L-serine"}
{"X":52607,"RHEA_ID":57844,"DIRECTION":"UN","MASTER_ID":57844,"ec":"1.14.14.164","compounds":"fraxetin + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sideretin (reduced form)"}
{"X":52608,"RHEA_ID":54502,"compounds":"beta-geranylfarnesene + diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate"}
{"X":52609,"RHEA_ID":61425,"DIRECTION":"LR","MASTER_ID":61424,"metacyc":"RXN-20748","compounds":"cis-cis-nepetalactol + NAD(+) => cis-cis-nepetalactone + H(+) + NADH"}
{"X":52610,"RHEA_ID":51189,"DIRECTION":"LR","MASTER_ID":51188,"reactome":"R-HSA-8942052.1","compounds":"nitric oxide + superoxide => peroxynitrite"}
{"X":52611,"RHEA_ID":61428,"DIRECTION":"UN","MASTER_ID":61428,"ec":"1.1.1.419","compounds":"cis-trans-nepetalactol + NAD(+) = cis-trans-nepetalactone + H(+) + NADH"}
{"X":52612,"RHEA_ID":51189,"DIRECTION":"LR","MASTER_ID":51188,"reactome":"R-HSA-1497878.1","compounds":"nitric oxide + superoxide => peroxynitrite"}
{"X":52613,"RHEA_ID":51189,"DIRECTION":"LR","MASTER_ID":51188,"reactome":"R-HSA-1222407.2","compounds":"nitric oxide + superoxide => peroxynitrite"}
{"X":52614,"RHEA_ID":54508,"DIRECTION":"UN","MASTER_ID":54508,"ec":"4.2.3.188","compounds":"all-trans-heptaprenyl diphosphate = beta-heptaprene + diphosphate"}
{"X":52615,"RHEA_ID":61432,"DIRECTION":"UN","MASTER_ID":61432,"ec":"1.3.1.123","compounds":"(R)-8-oxocitronellyl enol + NADP(+) = (6E)-8-oxogeranial + H(+) + NADPH"}
{"X":52616,"RHEA_ID":51192,"compounds":"(R)-2-hydroxyglutarate + NADP(+) = 2-oxoglutarate + H(+) + NADPH"}
{"X":52617,"RHEA_ID":61434,"DIRECTION":"RL","MASTER_ID":61432,"metacyc":"RXN-20749","compounds":"(6E)-8-oxogeranial + H(+) + NADPH => (R)-8-oxocitronellyl enol + NADP(+)"}
{"X":52618,"RHEA_ID":54512,"DIRECTION":"UN","MASTER_ID":54512,"ec":"4.2.3.189","compounds":"peregrinol diphosphate = (13R)-9,13-epoxylabd-14-ene + diphosphate"}
{"X":52619,"RHEA_ID":57856,"DIRECTION":"UN","MASTER_ID":57856,"ec":"1.14.11.61","compounds":"(E)-feruloyl-CoA + 2-oxoglutarate + O2 = (E)-6-hydroxyferuloyl-CoA + CO2 + succinate"}
{"X":52620,"RHEA_ID":54514,"compounds":"(13R)-9,13-epoxylabd-14-ene + diphosphate => peregrinol diphosphate"}
{"X":52621,"RHEA_ID":61437,"DIRECTION":"LR","MASTER_ID":61436,"metacyc":"RXN-10862","compounds":"ADP + H2O => AMP + H(+) + phosphate"}
{"X":52622,"RHEA_ID":54516,"DIRECTION":"UN","MASTER_ID":54516,"ec":"4.2.3.190","compounds":"8-hydroxycopalyl diphosphate = (13R)-manoyl oxide + diphosphate"}
{"X":52623,"RHEA_ID":61440,"compounds":"acetyl-CoA + S-(2-succino)-L-cysteine = CoA + H(+) + N-acetyl-S-(2-succino)-L-cysteine"}
{"X":52624,"RHEA_ID":54518,"compounds":"(13R)-manoyl oxide + diphosphate => 8-hydroxycopalyl diphosphate"}
{"X":52625,"RHEA_ID":61442,"compounds":"CoA + H(+) + N-acetyl-S-(2-succino)-L-cysteine => acetyl-CoA + S-(2-succino)-L-cysteine"}
{"X":52626,"RHEA_ID":54520,"DIRECTION":"UN","MASTER_ID":54520,"ec":"4.2.3.191","compounds":"all-trans-geranylgeranyl diphosphate = cycloaraneosene + diphosphate"}
{"X":52627,"RHEA_ID":61443,"compounds":"acetyl-CoA + S-(2-succino)-L-cysteine <=> CoA + H(+) + N-acetyl-S-(2-succino)-L-cysteine"}
{"X":52628,"RHEA_ID":51204,"compounds":"6-trans-leukotriene B4 + NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH"}
{"X":52629,"RHEA_ID":61446,"compounds":"an 11a-hydroxytetracycline + H2O + NADP(+) => a tetracycline + H(+) + NADPH + O2"}
{"X":52630,"RHEA_ID":54524,"compounds":"acetoacetate + H(+) + methylglyoxal = 3-hydroxyhexane-2,5-dione + CO2"}
{"X":52631,"RHEA_ID":61447,"compounds":"a tetracycline + H(+) + NADPH + O2 <=> an 11a-hydroxytetracycline + H2O + NADP(+)"}
{"X":52632,"RHEA_ID":51208,"compounds":"20-hydroxy-leukotriene B4 + NADP(+) = 12-oxo-20-hydroxy-leukotriene B4 + H(+) + NADPH"}
{"X":52633,"RHEA_ID":61450,"compounds":"11a-hydroxytigecycline + H2O + NADP(+) => H(+) + NADPH + O2 + tigecycline"}
{"X":52634,"RHEA_ID":54528,"compounds":"aldehydo-D-ribose 5-phosphate = D-ribose 5-phosphate"}
{"X":52635,"RHEA_ID":61452,"compounds":"H(+) + NADPH + O2 + oxytetracycline = 11a-hydroxy-oxytetracycline + H2O + NADP(+)"}
{"X":52636,"RHEA_ID":51212,"compounds":"(5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH"}
{"X":52637,"RHEA_ID":61454,"compounds":"11a-hydroxy-oxytetracycline + H2O + NADP(+) => H(+) + NADPH + O2 + oxytetracycline"}
{"X":52638,"RHEA_ID":51214,"compounds":"12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH => (5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP(+)"}
{"X":52639,"RHEA_ID":61456,"compounds":"7-chlorotetracycline + H(+) + NADPH + O2 = (1S,10S,10aS)-3-(CONH2)-9-Cl-1-(Me2N)-3,3a,4,10-(HO)4-10-Me-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracen-6-olate + CO + H2O + NADP(+)"}
{"X":52640,"RHEA_ID":51216,"compounds":"3'-phosphoadenylyl sulfate + 3beta-hydroxyandrost-5-en-17-one = 3beta-sulfooxy-androst-5-en-17-one + adenosine 3',5'-bisphosphate + H(+)"}
{"X":52641,"RHEA_ID":51217,"DIRECTION":"LR","MASTER_ID":51216,"reactome":"R-HSA-176631.2","compounds":"3'-phosphoadenylyl sulfate + 3beta-hydroxyandrost-5-en-17-one => 3beta-sulfooxy-androst-5-en-17-one + adenosine 3',5'-bisphosphate + H(+)"}
{"X":52642,"RHEA_ID":57879,"compounds":"uridine(54) in tRNA <=> pseudouridine(54) in tRNA"}
{"X":52643,"RHEA_ID":61460,"compounds":"a cytidine in RNA + S-adenosyl-L-methionine = a 5-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":52644,"RHEA_ID":51220,"DIRECTION":"UN","MASTER_ID":51220,"ec":"2.5.1.18","compounds":"1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)"}
{"X":52645,"RHEA_ID":61462,"compounds":"a 5-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in RNA + S-adenosyl-L-methionine"}
{"X":52646,"RHEA_ID":57883,"compounds":"3-O-[(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-threonyl-[protein] + UDP-alpha-D-xylose <=> 3-O-[beta-D-xylosyl-(1->4)-(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-threonyl-[protein] + H(+) + UDP"}
{"X":52647,"RHEA_ID":61463,"compounds":"a cytidine in RNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":52648,"RHEA_ID":51224,"DIRECTION":"UN","MASTER_ID":51224,"ec":"2.8.5.2","compounds":"2 [Fe(III)cytochrome c] + S-sulfanyl-L-cysteinyl-[SoxY protein] + thiosulfate = 2 [Fe(II)cytochrome c] + 2 H(+) + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein]"}
{"X":52649,"RHEA_ID":61466,"compounds":"a 5-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in mRNA + S-adenosyl-L-methionine"}
{"X":52650,"RHEA_ID":51226,"compounds":"2 [Fe(II)cytochrome c] + 2 H(+) + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein] => 2 [Fe(III)cytochrome c] + S-sulfanyl-L-cysteinyl-[SoxY protein] + thiosulfate"}
{"X":52651,"RHEA_ID":61467,"compounds":"a cytidine in mRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":52652,"RHEA_ID":51228,"compounds":"17alpha-ethynylestradiol + 3'-phosphoadenylyl sulfate = 17alpha-ethynylestradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)"}
{"X":52653,"RHEA_ID":61470,"compounds":"a 5-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in tRNA + S-adenosyl-L-methionine"}
{"X":52654,"RHEA_ID":51230,"compounds":"17alpha-ethynylestradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+) => 17alpha-ethynylestradiol + 3'-phosphoadenylyl sulfate"}
{"X":52655,"RHEA_ID":57892,"compounds":"a quinone + 5 H(+)(in) + NADPH = a quinol + 4 H(+)(out) + NADP(+)"}
{"X":52656,"RHEA_ID":51232,"compounds":"2-glyceryl-prostaglandin H2 = 2-glyceryl-prostaglandin D2"}
{"X":52657,"RHEA_ID":61474,"compounds":"an N-hexadecanoyl-sphingoid base + CoA + H(+) => a sphingoid base + hexadecanoyl-CoA"}
{"X":52658,"RHEA_ID":51234,"compounds":"2-glyceryl-prostaglandin D2 => 2-glyceryl-prostaglandin H2"}
{"X":52659,"RHEA_ID":61476,"DIRECTION":"UN","MASTER_ID":61476,"ec":"2.3.1.299","compounds":"a sphingoid base + octadecanoyl-CoA = an N-octadecanoyl-sphingoid base + CoA + H(+)"}
{"X":52660,"RHEA_ID":51236,"compounds":"GTP + L-glutamate + oxidized coenzyme F420-(gamma-Glu)(n) = GDP + H(+) + oxidized coenzyme F420-(gamma-Glu)(n+1) + phosphate"}
{"X":52661,"RHEA_ID":61478,"compounds":"an N-octadecanoyl-sphingoid base + CoA + H(+) => a sphingoid base + octadecanoyl-CoA"}
{"X":52662,"RHEA_ID":51238,"compounds":"GDP + H(+) + oxidized coenzyme F420-(gamma-Glu)(n+1) + phosphate => GTP + L-glutamate + oxidized coenzyme F420-(gamma-Glu)(n)"}
{"X":52663,"RHEA_ID":61479,"compounds":"a sphingoid base + octadecanoyl-CoA <=> an N-octadecanoyl-sphingoid base + CoA + H(+)"}
{"X":52664,"RHEA_ID":57901,"compounds":"2-oxoglutarate + N(6)-methyladenosine in U6 snRNA + O2 => adenosine in U6 snRNA + CO2 + formaldehyde + succinate"}
{"X":52665,"RHEA_ID":61482,"compounds":"an N-(very-long-chain fatty acyl)-sphingoid base + CoA + H(+) => a sphingoid base + a very long-chain fatty acyl-CoA"}
{"X":52666,"RHEA_ID":51242,"compounds":"(13R)-hydroperoxy-(9Z,11E)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2"}
{"X":52667,"RHEA_ID":51243,"compounds":"(9Z,12Z)-octadecadienoate + O2 <=> (13R)-hydroperoxy-(9Z,11E)-octadecadienoate"}
{"X":52668,"RHEA_ID":51244,"compounds":"(9Z,12Z,15Z)-octadecatrienoate + O2 = (13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate"}
{"X":52669,"RHEA_ID":51245,"compounds":"(9Z,12Z,15Z)-octadecatrienoate + O2 => (13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate"}
{"X":52670,"RHEA_ID":51246,"compounds":"(13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2"}
{"X":52671,"RHEA_ID":51247,"compounds":"(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate"}
{"X":52672,"RHEA_ID":51248,"compounds":"(9Z,12Z,15Z)-octadecatrienoate + O2 = (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate"}
{"X":52673,"RHEA_ID":61490,"compounds":"5-methylcytidine(50) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(50) in tRNA + S-adenosyl-L-methionine"}
{"X":52674,"RHEA_ID":51250,"compounds":"(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2"}
{"X":52675,"RHEA_ID":61492,"DIRECTION":"UN","MASTER_ID":61492,"ec":"2.3.1.298","compounds":"a sphingoid base + ultra-long-chain fatty acyl-CoA = an N-(ultra-long-chain-acyl)-sphingoid base + CoA + H(+)"}
{"X":52676,"RHEA_ID":57913,"DIRECTION":"LR","MASTER_ID":57912,"metacyc":"RXN-20083","compounds":"5-phosphooxy-L-glutamyl-tRNA(Gln) + NH4(+) => H(+) + L-glutaminyl-tRNA(Gln) + phosphate"}
{"X":52677,"RHEA_ID":61494,"compounds":"an N-(ultra-long-chain-acyl)-sphingoid base + CoA + H(+) => a sphingoid base + ultra-long-chain fatty acyl-CoA"}
{"X":52678,"RHEA_ID":51254,"compounds":"(11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2"}
{"X":52679,"RHEA_ID":61496,"DIRECTION":"UN","MASTER_ID":61496,"ec":"2.4.1.370","compounds":"an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose = a mannosylinositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base + GDP + H(+)"}
{"X":52680,"RHEA_ID":51256,"compounds":"(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate + O2 = (9S,16S)-dihydroperoxy-(10E,12Z,14E)-octadecatrienoate"}
{"X":52681,"RHEA_ID":61498,"compounds":"a mannosylinositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base + GDP + H(+) => an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose"}
{"X":52682,"RHEA_ID":51258,"compounds":"(9S,16S)-dihydroperoxy-(10E,12Z,14E)-octadecatrienoate => (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate + O2"}
{"X":52683,"RHEA_ID":61500,"DIRECTION":"UN","MASTER_ID":61500,"ec":"2.4.1.115","compounds":"delphinidin + UDP-alpha-D-glucose = delphinidin 3-O-beta-D-glucoside + UDP"}
{"X":52684,"RHEA_ID":53476,"compounds":"1-hexadecanoyl-2-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (6Z,9Z,12Z)-octadecatrienoate"}
{"X":52685,"RHEA_ID":61502,"compounds":"delphinidin 3-O-beta-D-glucoside + UDP => delphinidin + UDP-alpha-D-glucose"}
{"X":52686,"RHEA_ID":57923,"compounds":"4-phosphooxy-L-aspartyl-tRNA(Asn) + NH4(+) <=> H(+) + L-asparaginyl-tRNA(Asn) + phosphate"}
{"X":52687,"RHEA_ID":52380,"DIRECTION":"UN","MASTER_ID":52380,"ec":"2.4.99.2","compounds":"a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+)"}
{"X":52688,"RHEA_ID":59037,"DIRECTION":"LR","MASTER_ID":59036,"metacyc":"RXN-11936","compounds":"4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":52689,"RHEA_ID":61506,"compounds":"pelargonidin 3-O-beta-D-glucoside + UDP => pelargonidin + UDP-alpha-D-glucose"}
{"X":52690,"RHEA_ID":57927,"compounds":"H2O + mutildienyl diphosphate <=> diphosphate + premutilin"}
{"X":52691,"RHEA_ID":52384,"DIRECTION":"UN","MASTER_ID":52384,"ec":"2.5.1.140","compounds":"L-glutamate + O-phospho-L-serine = H(+) + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + phosphate"}
{"X":52692,"RHEA_ID":51268,"DIRECTION":"UN","MASTER_ID":51268,"ec":"2.1.1.336","compounds":"norbelladine + S-adenosyl-L-methionine = 4'-O-methylnorbelladine + H(+) + S-adenosyl-L-homocysteine"}
{"X":52693,"RHEA_ID":61510,"compounds":"peonidin 3-O-beta-D-glucoside + UDP => peonidin + UDP-alpha-D-glucose"}
{"X":52694,"RHEA_ID":54588,"DIRECTION":"UN","MASTER_ID":54588,"ec":"2.1.1.313","compounds":"S-adenosyl-L-methionine + uridine in 25S rRNA = H(+) + N(3)-methyluridine in 25S rRNA + S-adenosyl-L-homocysteine"}
{"X":52695,"RHEA_ID":54589,"compounds":"S-adenosyl-L-methionine + uridine in 25S rRNA => H(+) + N(3)-methyluridine in 25S rRNA + S-adenosyl-L-homocysteine"}
{"X":52696,"RHEA_ID":54590,"compounds":"H(+) + N(3)-methyluridine in 25S rRNA + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine in 25S rRNA"}
{"X":52697,"RHEA_ID":61514,"compounds":"malvidin 3-O-beta-D-glucoside + UDP => malvidin + UDP-alpha-D-glucose"}
{"X":52698,"RHEA_ID":51274,"compounds":"CoA + H(+) + N-(9Z-octadecenoyl)glycine => (9Z)-octadecenoyl-CoA + glycine"}
{"X":52699,"RHEA_ID":61520,"compounds":"AH2 + dopamine = 3-tyramine + A + H2O"}
{"X":52700,"RHEA_ID":59049,"DIRECTION":"LR","MASTER_ID":59048,"metacyc":"RXN-20175","compounds":"D-ornithine + H(+) => CO2 + putrescine"}
{"X":52701,"RHEA_ID":61522,"compounds":"3-tyramine + A + H2O => AH2 + dopamine"}
{"X":52702,"RHEA_ID":51278,"compounds":"(9S)-hydroperoxy-(10E,12Z)-octadecadienoate => (11S)-hydroperoxy-(9Z,12Z)-octadecadienoate"}
{"X":52703,"RHEA_ID":57940,"compounds":"Fe-coproporphyrin III + H(+) + H2O2 = CO2 + 2 H2O + harderoheme III"}
{"X":52704,"RHEA_ID":51280,"compounds":"(13R)-hydroperoxy-(9Z,11E)-octadecadienoate = (9S)-hydroperoxy-(10E,12Z)-octadecadienoate"}
{"X":52705,"RHEA_ID":51281,"compounds":"(13R)-hydroperoxy-(9Z,11E)-octadecadienoate => (9S)-hydroperoxy-(10E,12Z)-octadecadienoate"}
{"X":52706,"RHEA_ID":51282,"compounds":"(9S)-hydroperoxy-(10E,12Z)-octadecadienoate => (13R)-hydroperoxy-(9Z,11E)-octadecadienoate"}
{"X":52707,"RHEA_ID":61528,"DIRECTION":"UN","MASTER_ID":61528,"ec":"2.3.1.296","compounds":"a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphingoid base = a diacylglycerol + an N-[omega-(9Z,12Z-octadecadienoyloxy)-O-ultra-long chain fatty acyl]-sphingoid base"}
{"X":52708,"RHEA_ID":54602,"compounds":"2-hydroxyoctanoyl-CoA + CO2 + succinate => 2-oxoglutarate + O2 + octanoyl-CoA"}
{"X":52709,"RHEA_ID":61530,"compounds":"a diacylglycerol + an N-[omega-(9Z,12Z-octadecadienoyloxy)-O-ultra-long chain fatty acyl]-sphingoid base => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphingoid base"}
{"X":52710,"RHEA_ID":57947,"compounds":"H(+) + H2O2 + harderoheme III <=> CO2 + 2 H2O + heme b"}
{"X":52711,"RHEA_ID":61564,"compounds":"a tetracycline + H(+) + NADPH + O2 = a (1S,10aS)-3-(CONH2)-1-(Me2N)-3,3a,4,6-(HO)4-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracene + CO + H2O + NADP(+)"}
{"X":52712,"RHEA_ID":54606,"compounds":"2-hydroxydecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + decanoyl-CoA + O2"}
{"X":52713,"RHEA_ID":61566,"compounds":"a (1S,10aS)-3-(CONH2)-1-(Me2N)-3,3a,4,6-(HO)4-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracene + CO + H2O + NADP(+) => a tetracycline + H(+) + NADPH + O2"}
{"X":52714,"RHEA_ID":51290,"compounds":"(13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => (11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate"}
{"X":52715,"RHEA_ID":61568,"compounds":"an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O = an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + D-galactosamine"}
{"X":52716,"RHEA_ID":57953,"DIRECTION":"LR","MASTER_ID":57952,"metacyc":"RXN-17503","compounds":"H(+) + NADH + O2 + phenol => catechol + H2O + NAD(+)"}
{"X":52717,"RHEA_ID":61570,"compounds":"an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + D-galactosamine => an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O"}
{"X":52718,"RHEA_ID":51294,"DIRECTION":"RL","MASTER_ID":51292,"ecocyc":"RXN-17652","metacyc":"RXN-17652","compounds":"a quinol + L-methionyl-(S)-S-oxide-[protein] => a quinone + H2O + L-methionyl-[protein]"}
{"X":52719,"RHEA_ID":51295,"compounds":"a quinone + H2O + L-methionyl-[protein] <=> a quinol + L-methionyl-(S)-S-oxide-[protein]"}
{"X":52720,"RHEA_ID":57957,"DIRECTION":"LR","MASTER_ID":57956,"metacyc":"RXN-9767","compounds":"dimethyl sulfoxide + H(+) + NADH + O2 => dimethyl sulfone + H2O + NAD(+)"}
{"X":52721,"RHEA_ID":51297,"compounds":"a quinone + H2O + L-methionyl-[protein] => a quinol + L-methionyl-(R)-S-oxide-[protein]"}
{"X":52722,"RHEA_ID":51298,"DIRECTION":"RL","MASTER_ID":51296,"ecocyc":"RXN-17663","metacyc":"RXN-17663","compounds":"a quinol + L-methionyl-(R)-S-oxide-[protein] => a quinone + H2O + L-methionyl-[protein]"}
{"X":52723,"RHEA_ID":57960,"DIRECTION":"UN","MASTER_ID":57960,"ec":"1.14.13.245","compounds":"dimethyl sulfide + H(+) + NADH + O2 = dimethyl sulfoxide + H2O + NAD(+)"}
{"X":52724,"RHEA_ID":57961,"DIRECTION":"LR","MASTER_ID":57960,"metacyc":"RXN-20073","compounds":"dimethyl sulfide + H(+) + NADH + O2 => dimethyl sulfoxide + H2O + NAD(+)"}
{"X":52725,"RHEA_ID":51301,"compounds":"(9Z)-octadecenoate + L-phenylalanine => H2O + N-(9Z-octadecenoyl)-L-phenylalanine"}
{"X":52726,"RHEA_ID":51302,"compounds":"H2O + N-(9Z-octadecenoyl)-L-phenylalanine => (9Z)-octadecenoate + L-phenylalanine"}
{"X":52727,"RHEA_ID":61580,"DIRECTION":"UN","MASTER_ID":61580,"ec":"1.3.1.120","compounds":"(3S)-3-hydroxycyclohexane-1-carbonyl-CoA + NADP(+) = (5S)-5-hydroxycyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH"}
{"X":52728,"RHEA_ID":59077,"compounds":"bis(myo-inositol) 1,3'-phosphate + 2 GDP-alpha-D-mannose => 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + 2 GDP + 2 H(+)"}
{"X":52729,"RHEA_ID":51305,"compounds":"(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate => (13R)-hydroperoxy-(9Z,11E)-octadecadienoate"}
{"X":52730,"RHEA_ID":51306,"compounds":"(13R)-hydroperoxy-(9Z,11E)-octadecadienoate => (11S)-hydroperoxy-(9Z,12Z)-octadecadienoate"}
{"X":52731,"RHEA_ID":54625,"compounds":"2-oxoglutarate + O2 + octadecanoyl-CoA => 2-hydroxyoctadecanoyl-CoA + CO2 + succinate"}
{"X":52732,"RHEA_ID":57969,"DIRECTION":"LR","MASTER_ID":57968,"metacyc":"RXN-20051","compounds":"germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => 8-epi-inunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52733,"RHEA_ID":51309,"compounds":"H(+) + L-methionyl-[F-actin] + NADPH + O2 => H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+)"}
{"X":52734,"RHEA_ID":51310,"compounds":"H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+) => H(+) + L-methionyl-[F-actin] + NADPH + O2"}
{"X":52735,"RHEA_ID":54629,"compounds":"2-oxoglutarate + dodecanoyl-CoA + O2 => 2-hydroxydodecanoyl-CoA + CO2 + succinate"}
{"X":52736,"RHEA_ID":57973,"DIRECTION":"LR","MASTER_ID":57972,"metacyc":"RXN-20054","compounds":"8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => eupatolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52737,"RHEA_ID":51313,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine"}
{"X":52738,"RHEA_ID":51314,"compounds":"H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine"}
{"X":52739,"RHEA_ID":61596,"compounds":"[DsbD protein]-dithiol + [thioredoxin]-disulfide = [DsbD protein]-disulfide + [thioredoxin]-dithiol"}
{"X":52740,"RHEA_ID":57977,"DIRECTION":"LR","MASTER_ID":57976,"metacyc":"RXN-19697","compounds":"(20S)-protopanaxadiol + UDP-alpha-D-glucose => (20S)-ginsenoside C-K + H(+) + UDP"}
{"X":52741,"RHEA_ID":51317,"compounds":"(9Z)-octadecenoate + glycine => H2O + N-(9Z-octadecenoyl)glycine"}
{"X":52742,"RHEA_ID":51318,"compounds":"H2O + N-(9Z-octadecenoyl)glycine => (9Z)-octadecenoate + glycine"}
{"X":52743,"RHEA_ID":61600,"compounds":"[DsbD protein]-disulfide + [protein]-dithiol = [DsbB protein]-dithiol + [protein]-disulfide"}
{"X":52744,"RHEA_ID":61601,"compounds":"[DsbD protein]-disulfide + [protein]-dithiol => [DsbB protein]-dithiol + [protein]-disulfide"}
{"X":52745,"RHEA_ID":56870,"compounds":"(2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + CoA => (2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + octanoyl-CoA"}
{"X":52746,"RHEA_ID":51326,"compounds":"(8R)-hydroperoxy-(9E,11Z,14Z)-eicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2"}
{"X":52747,"RHEA_ID":51327,"compounds":"(8Z,11Z,14Z)-eicosatrienoate + O2 <=> (8R)-hydroperoxy-(9E,11Z,14Z)-eicosatrienoate"}
{"X":52748,"RHEA_ID":57985,"DIRECTION":"LR","MASTER_ID":57984,"metacyc":"RXN-19704","compounds":"(20S)-ginsenoside Rg3 + UDP-alpha-D-glucose => (20S)-ginsenoside Rd + H(+) + UDP"}
{"X":52749,"RHEA_ID":51329,"compounds":"(8Z,11Z,14Z)-eicosatrienoate + O2 => 10-hydroperoxy-(8Z,11Z,14Z)-eicosatrienoate"}
{"X":52750,"RHEA_ID":51330,"compounds":"10-hydroperoxy-(8Z,11Z,14Z)-eicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2"}
{"X":52751,"RHEA_ID":51331,"compounds":"(8Z,11Z,14Z)-eicosatrienoate + O2 <=> 10-hydroperoxy-(8Z,11Z,14Z)-eicosatrienoate"}
{"X":52752,"RHEA_ID":57989,"DIRECTION":"LR","MASTER_ID":57988,"metacyc":"RXN-19703","compounds":"(20S)-ginsenoside Rh2 + UDP-alpha-D-glucose => (20S)-ginsenoside F2 + H(+) + UDP"}
{"X":52753,"RHEA_ID":51333,"compounds":"(8Z,11Z,14Z)-eicosatrienoate + O2 => 11-hydroperoxy-(8Z,12E,14Z)-eicosatrienoate"}
{"X":52754,"RHEA_ID":51334,"compounds":"11-hydroperoxy-(8Z,12E,14Z)-eicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2"}
{"X":52755,"RHEA_ID":54649,"compounds":"ent-8alpha-hydroxylabd-13-en-15-yl diphosphate => all-trans-geranylgeranyl diphosphate + H2O"}
{"X":52756,"RHEA_ID":57993,"DIRECTION":"LR","MASTER_ID":57992,"metacyc":"RXN-19696","compounds":"(20S)-ginsenoside C-K + UDP-alpha-D-glucose => (20S)-ginsenoside F2 + H(+) + UDP"}
{"X":52757,"RHEA_ID":51337,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 => 8-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate"}
{"X":52758,"RHEA_ID":51338,"compounds":"8-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2"}
{"X":52759,"RHEA_ID":55780,"compounds":"all-trans-5,6-epoxyretinoate + UDP-alpha-D-glucuronate = all-trans-5,6-epoxyretinoyl-1-O-(beta-D-glucuronate) + UDP"}
{"X":52760,"RHEA_ID":59109,"compounds":"chenodeoxycholate + octyl beta-D-glucose => beta-D-glucosyl-(1->3)-O-chenodeoxycholate + octan-1-ol"}
{"X":52761,"RHEA_ID":51341,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => 10-hydroperoxy-(4Z,7Z,11E,13Z,16Z,19Z)-docosahexaenoate"}
{"X":52762,"RHEA_ID":51342,"compounds":"10-hydroperoxy-(4Z,7Z,11E,13Z,16Z,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2"}
{"X":52763,"RHEA_ID":54657,"compounds":"linalool => geraniol"}
{"X":52764,"RHEA_ID":58001,"DIRECTION":"LR","MASTER_ID":58000,"metacyc":"RXN-19699","compounds":"(20S)-ginsenoside Rh2 + UDP-alpha-D-glucose => (20S)-ginsenoside Rg3 + H(+) + UDP"}
{"X":52765,"RHEA_ID":51345,"compounds":"(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => 8,9-epoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O"}
{"X":52766,"RHEA_ID":51346,"compounds":"8,9-epoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O => (8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate"}
{"X":52767,"RHEA_ID":51347,"compounds":"(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate <=> 8,9-epoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O"}
{"X":52768,"RHEA_ID":59117,"compounds":"[protein]-dithiol + O2 => [protein]-disulfide + H2O2"}
{"X":52769,"RHEA_ID":61630,"compounds":"1-piperideine + H2O => 5-aminopentanal"}
{"X":52770,"RHEA_ID":51350,"compounds":"10 A + 7 CO2 + 8 CoA + dehydroprobetaenone I + 6 H2O + 5 S-adenosyl-L-homocysteine => acetyl-CoA + 10 AH2 + 2 H(+) + 7 malonyl-CoA + 5 S-adenosyl-L-methionine"}
{"X":52771,"RHEA_ID":52464,"compounds":"17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":52772,"RHEA_ID":59121,"DIRECTION":"LR","MASTER_ID":59120,"metacyc":"RXN-19821","compounds":"2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + H(+) => 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + CO2"}
{"X":52773,"RHEA_ID":51353,"compounds":"H2O + N-(9Z-octadecenoyl)-L-serine => (9Z)-octadecenoate + L-serine"}
{"X":52774,"RHEA_ID":51354,"compounds":"(9Z)-octadecenoate + L-serine => H2O + N-(9Z-octadecenoyl)-L-serine"}
{"X":52775,"RHEA_ID":51355,"compounds":"H2O + N-(9Z-octadecenoyl)-L-serine <=> (9Z)-octadecenoate + L-serine"}
{"X":52776,"RHEA_ID":61640,"DIRECTION":"UN","MASTER_ID":61640,"ec":"4.1.1.118","compounds":"H(+) + isophthalyl-CoA = benzoyl-CoA + CO2"}
{"X":52777,"RHEA_ID":51357,"compounds":"H2O + N-(9Z-octadecenoyl)-L-glutamine => (9Z)-octadecenoate + L-glutamine"}
{"X":52778,"RHEA_ID":51358,"compounds":"(9Z)-octadecenoate + L-glutamine => H2O + N-(9Z-octadecenoyl)-L-glutamine"}
{"X":52779,"RHEA_ID":61644,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + N(omega)-hydroxy-L-arginine = 2 [Fe(III)-cytochrome b5] + H2O + L-arginine"}
{"X":52780,"RHEA_ID":55801,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + N-acyleicosasphinganine + O2 => 2 [Fe(III)-cytochrome b5] + 2 H2O + N-acyleicosasphing-4-enine"}
{"X":52781,"RHEA_ID":51361,"compounds":"H2O + N-(9Z-octadecenoyl)-L-leucine => (9Z)-octadecenoate + L-leucine"}
{"X":52782,"RHEA_ID":51362,"compounds":"(9Z)-octadecenoate + L-leucine => H2O + N-(9Z-octadecenoyl)-L-leucine"}
{"X":52783,"RHEA_ID":61656,"DIRECTION":"UN","MASTER_ID":61656,"ec":"2.7.1.216","compounds":"(2E,6E)-farnesol + ATP = (2E,6E)-farnesyl phosphate + ADP + H(+)"}
{"X":52784,"RHEA_ID":51364,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = CoA + H(+) + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine"}
{"X":52785,"RHEA_ID":61657,"DIRECTION":"LR","MASTER_ID":61656,"metacyc":"RXN-12304","compounds":"(2E,6E)-farnesol + ATP => (2E,6E)-farnesyl phosphate + ADP + H(+)"}
{"X":52786,"RHEA_ID":51366,"compounds":"CoA + H(+) + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine"}
{"X":52787,"RHEA_ID":61660,"DIRECTION":"UN","MASTER_ID":61660,"ec":"2.7.1.216","compounds":"ATP + geraniol = (2E)-geranyl phosphate + ADP + H(+)"}
{"X":52788,"RHEA_ID":58024,"DIRECTION":"UN","MASTER_ID":58024,"ec":"2.4.1.368","compounds":"oleanolate + UDP-alpha-D-glucose = H(+) + oleanolate 3-O-beta-D-glucoside + UDP"}
{"X":52789,"RHEA_ID":61662,"compounds":"(2E)-geranyl phosphate + ADP + H(+) => ATP + geraniol"}
{"X":52790,"RHEA_ID":51370,"compounds":"CoA + H(+) + N-octadecanoylglycine => glycine + octadecanoyl-CoA"}
{"X":52791,"RHEA_ID":61664,"DIRECTION":"UN","MASTER_ID":61664,"ec":"2.7.1.216","compounds":"(2E,6E,10E)-geranylgeraniol + ATP = (2E,6E,10E)-geranylgeranyl phosphate + ADP + H(+)"}
{"X":52792,"RHEA_ID":59141,"DIRECTION":"LR","MASTER_ID":59140,"metacyc":"RXN-19521","compounds":"ATP + citrate + N(5)-[(S)-citryl]-D-ornithine => AMP + diphosphate + H(+) + staphyloferrin A"}
{"X":52793,"RHEA_ID":51373,"compounds":"(9Z)-hexadecenoyl-CoA + glycine => CoA + H(+) + N-(9Z-hexadecenoyl)-glycine"}
{"X":52794,"RHEA_ID":61667,"compounds":"(2E,6E,10E)-geranylgeraniol + ATP <=> (2E,6E,10E)-geranylgeranyl phosphate + ADP + H(+)"}
{"X":52795,"RHEA_ID":51375,"compounds":"(9Z)-hexadecenoyl-CoA + glycine <=> CoA + H(+) + N-(9Z-hexadecenoyl)-glycine"}
{"X":52796,"RHEA_ID":61685,"compounds":"glycero-2-phosphocholine + H2O => glycerol + H(+) + phosphocholine"}
{"X":52797,"RHEA_ID":55818,"compounds":"5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide d + H(+) + L-methionine => a bacteriochlorophyllide d + H2O + S-adenosyl-L-methionine"}
{"X":52798,"RHEA_ID":61687,"compounds":"glycero-2-phosphocholine + H2O <=> glycerol + H(+) + phosphocholine"}
{"X":52799,"RHEA_ID":61712,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + N(omega)-hydroxy-N(delta)-methyl-L-arginine = 2 [Fe(III)-cytochrome b5] + H2O + N(delta)-methyl-L-arginine"}
{"X":52800,"RHEA_ID":61713,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + N(omega)-hydroxy-N(delta)-methyl-L-arginine => 2 [Fe(III)-cytochrome b5] + H2O + N(delta)-methyl-L-arginine"}
{"X":52801,"RHEA_ID":51381,"compounds":"(9Z)-octadecenoyl-CoA + dopamine => CoA + H(+) + N-(9Z-octadecanoyl)-dopamine"}
{"X":52802,"RHEA_ID":51382,"compounds":"CoA + H(+) + N-(9Z-octadecanoyl)-dopamine => (9Z)-octadecenoyl-CoA + dopamine"}
{"X":52803,"RHEA_ID":54701,"DIRECTION":"LR","MASTER_ID":54700,"metacyc":"RXN-17210","compounds":"4-hydroxybenzoyl-5'-AMP + holo-[4-hydroxyphenylalkanoate synthase] => 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + H(+)"}
{"X":52804,"RHEA_ID":58040,"compounds":"1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + H2O = (9Z,12Z,15Z)-octadecatrienoate + glycerol + H(+)"}
{"X":52805,"RHEA_ID":51385,"compounds":"hexadecanoyl-CoA + serotonin => CoA + H(+) + N-hexadecanoyl-serotonin"}
{"X":52806,"RHEA_ID":61719,"compounds":"ATP + D-galactofuranose(out) + H2O <=> ADP + D-galactofuranose(in) + H(+) + phosphate"}
{"X":52807,"RHEA_ID":61720,"compounds":"a D-guloside + NAD(+) = a 3-dehydro-D-guloside + H(+) + NADH"}
{"X":52808,"RHEA_ID":52501,"compounds":"(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] => (13R)-hydroxy-(9Z,11E)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52809,"RHEA_ID":61722,"compounds":"a 3-dehydro-D-guloside + H(+) + NADH => a D-guloside + NAD(+)"}
{"X":52810,"RHEA_ID":55831,"compounds":"cortisol + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52811,"RHEA_ID":54709,"DIRECTION":"LR","MASTER_ID":54708,"metacyc":"RXN-13224","compounds":"N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":52812,"RHEA_ID":51392,"compounds":"(9Z)-octadecenoyl-CoA + serotonin = CoA + H(+) + N-(9Z-octadecenoyl)-serotonin"}
{"X":52813,"RHEA_ID":51393,"compounds":"(9Z)-octadecenoyl-CoA + serotonin => CoA + H(+) + N-(9Z-octadecenoyl)-serotonin"}
{"X":52814,"RHEA_ID":51394,"compounds":"CoA + H(+) + N-(9Z-octadecenoyl)-serotonin => (9Z)-octadecenoyl-CoA + serotonin"}
{"X":52815,"RHEA_ID":61728,"compounds":"a 3-dehydro-D-guloside = a 3-dehydro-D-glucoside"}
{"X":52816,"RHEA_ID":51396,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + serotonin = CoA + H(+) + N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin"}
{"X":52817,"RHEA_ID":51397,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + serotonin => CoA + H(+) + N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin"}
{"X":52818,"RHEA_ID":61731,"DIRECTION":"BI","MASTER_ID":61728,"ecocyc":"RXN-20681","metacyc":"RXN-20681","compounds":"a 3-dehydro-D-guloside <=> a 3-dehydro-D-glucoside"}
{"X":52819,"RHEA_ID":61732,"compounds":"steviol + UDP-alpha-D-glucose = H(+) + steviolmonoside + UDP"}
{"X":52820,"RHEA_ID":61733,"DIRECTION":"LR","MASTER_ID":61732,"metacyc":"RXN-13511","compounds":"steviol + UDP-alpha-D-glucose => H(+) + steviolmonoside + UDP"}
{"X":52821,"RHEA_ID":61734,"compounds":"H(+) + steviolmonoside + UDP => steviol + UDP-alpha-D-glucose"}
{"X":52822,"RHEA_ID":61735,"compounds":"steviol + UDP-alpha-D-glucose <=> H(+) + steviolmonoside + UDP"}
{"X":52823,"RHEA_ID":54721,"DIRECTION":"LR","MASTER_ID":54720,"metacyc":"RXN-13224","compounds":"N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":52824,"RHEA_ID":61737,"DIRECTION":"LR","MASTER_ID":61736,"metacyc":"RXN-13512","compounds":"steviolmonoside + UDP-alpha-D-glucose => rubusoside + UDP"}
{"X":52825,"RHEA_ID":51405,"DIRECTION":"LR","MASTER_ID":51404,"metacyc":"ARG-OXIDATION-RXN","compounds":"H2O + L-arginine + O2 => 5-guanidino-2-oxopentanoate + H2O2 + NH4(+)"}
{"X":52826,"RHEA_ID":61739,"compounds":"steviolmonoside + UDP-alpha-D-glucose <=> rubusoside + UDP"}
{"X":52827,"RHEA_ID":58063,"compounds":"2-sulfinoacetaldehyde + H2O <=> acetaldehyde + H(+) + sulfite"}
{"X":52828,"RHEA_ID":61741,"DIRECTION":"LR","MASTER_ID":61740,"metacyc":"RXN-13513","compounds":"steviolmonoside + UDP-alpha-D-glucose => H(+) + steviolbioside + UDP"}
{"X":52829,"RHEA_ID":61742,"compounds":"H(+) + steviolbioside + UDP => steviolmonoside + UDP-alpha-D-glucose"}
{"X":52830,"RHEA_ID":61743,"compounds":"steviolmonoside + UDP-alpha-D-glucose <=> H(+) + steviolbioside + UDP"}
{"X":52831,"RHEA_ID":61744,"compounds":"steviolbioside + UDP-alpha-D-glucose = stevioside + UDP"}
{"X":52832,"RHEA_ID":54730,"compounds":"malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] => acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein]"}
{"X":52833,"RHEA_ID":51413,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 => (8R)-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate"}
{"X":52834,"RHEA_ID":51414,"compounds":"(8R)-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2"}
{"X":52835,"RHEA_ID":61748,"compounds":"rubusoside + UDP-alpha-D-glucose = H(+) + stevioside + UDP"}
{"X":52836,"RHEA_ID":61749,"DIRECTION":"LR","MASTER_ID":61748,"metacyc":"RXN-13515","compounds":"rubusoside + UDP-alpha-D-glucose => H(+) + stevioside + UDP"}
{"X":52837,"RHEA_ID":61750,"compounds":"H(+) + stevioside + UDP => rubusoside + UDP-alpha-D-glucose"}
{"X":52838,"RHEA_ID":61751,"compounds":"rubusoside + UDP-alpha-D-glucose <=> H(+) + stevioside + UDP"}
{"X":52839,"RHEA_ID":55860,"compounds":"all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-5,6-epoxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52840,"RHEA_ID":61753,"DIRECTION":"LR","MASTER_ID":61752,"metacyc":"RXN-13516","compounds":"steviolbioside + UDP-alpha-D-glucose => H(+) + rebaudioside B + UDP"}
{"X":52841,"RHEA_ID":61754,"compounds":"H(+) + rebaudioside B + UDP => steviolbioside + UDP-alpha-D-glucose"}
{"X":52842,"RHEA_ID":61755,"compounds":"steviolbioside + UDP-alpha-D-glucose <=> H(+) + rebaudioside B + UDP"}
{"X":52843,"RHEA_ID":54741,"compounds":"9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52844,"RHEA_ID":51424,"compounds":"a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in 18S rRNA + CoA + H(+) + phosphate"}
{"X":52845,"RHEA_ID":51425,"compounds":"a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O => ADP + an N(4)-acetylcytidine in 18S rRNA + CoA + H(+) + phosphate"}
{"X":52846,"RHEA_ID":61759,"compounds":"stevioside + UDP-alpha-D-glucose <=> H(+) + rebaudioside A + UDP"}
{"X":52847,"RHEA_ID":51427,"compounds":"a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O <=> ADP + an N(4)-acetylcytidine in 18S rRNA + CoA + H(+) + phosphate"}
{"X":52848,"RHEA_ID":51428,"DIRECTION":"UN","MASTER_ID":51428,"ec":"2.3.1.280","compounds":"acetyl-CoA + aminomethylphosphonate = 2-N-acetamidomethylphosphonate + CoA"}
{"X":52849,"RHEA_ID":51429,"DIRECTION":"LR","MASTER_ID":51428,"ecocyc":"RXN0-7014","metacyc":"RXN0-7014","compounds":"acetyl-CoA + aminomethylphosphonate => 2-N-acetamidomethylphosphonate + CoA"}
{"X":52850,"RHEA_ID":61763,"compounds":"rebaudioside B + UDP-alpha-D-glucose <=> rebaudioside A + UDP"}
{"X":52851,"RHEA_ID":61764,"compounds":"stevioside + UDP-alpha-D-glucose = H(+) + rebaudioside E + UDP"}
{"X":52852,"RHEA_ID":61765,"compounds":"stevioside + UDP-alpha-D-glucose => H(+) + rebaudioside E + UDP"}
{"X":52853,"RHEA_ID":61766,"compounds":"H(+) + rebaudioside E + UDP => stevioside + UDP-alpha-D-glucose"}
{"X":52854,"RHEA_ID":51434,"compounds":"[(1S)-1-acetamidoethyl]phosphonate + CoA => (S)-1-aminoethylphosphonate + acetyl-CoA"}
{"X":52855,"RHEA_ID":61768,"compounds":"rebaudioside A + UDP-alpha-D-glucose = H(+) + rebaudioside D + UDP"}
{"X":52856,"RHEA_ID":61769,"compounds":"rebaudioside A + UDP-alpha-D-glucose => H(+) + rebaudioside D + UDP"}
{"X":52857,"RHEA_ID":61770,"compounds":"H(+) + rebaudioside D + UDP => rebaudioside A + UDP-alpha-D-glucose"}
{"X":52858,"RHEA_ID":51438,"DIRECTION":"RL","MASTER_ID":51436,"metacyc":"AKPTHIOL-RXN","compounds":"(2R)-2-amino-4-oxopentanoate + CoA => acetyl-CoA + D-alanine"}
{"X":52859,"RHEA_ID":54757,"DIRECTION":"LR","MASTER_ID":54756,"metacyc":"RXN-19042","compounds":"deamido-NAD(+) + hydrogencarbonate => AMP + 2 H(+) + pyridinium-3,5-dicarboxylate mononucleotide"}
{"X":52860,"RHEA_ID":55885,"DIRECTION":"LR","MASTER_ID":55884,"metacyc":"RXN-18874","compounds":"[aequorin] + 3 Ca(2+) => [aequorin]--dioxetanone"}
{"X":52861,"RHEA_ID":61774,"compounds":"H(+) + rebaudioside D + UDP => rebaudioside E + UDP-alpha-D-glucose"}
{"X":52862,"RHEA_ID":51442,"compounds":"(11S)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2"}
{"X":52863,"RHEA_ID":54761,"DIRECTION":"LR","MASTER_ID":54760,"metacyc":"RXN-19043","compounds":"ATP + H(+) + pyridinium-3,5-dicarboxylate mononucleotide => 5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + diphosphate"}
{"X":52864,"RHEA_ID":54762,"compounds":"5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + diphosphate => ATP + H(+) + pyridinium-3,5-dicarboxylate mononucleotide"}
{"X":52865,"RHEA_ID":51445,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-leucine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-leucine"}
{"X":52866,"RHEA_ID":51446,"compounds":"H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-leucine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-leucine"}
{"X":52867,"RHEA_ID":51447,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-leucine <=> H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-leucine"}
{"X":52868,"RHEA_ID":61781,"compounds":"keto-L-tagatose => keto-L-sorbose"}
{"X":52869,"RHEA_ID":54767,"compounds":"5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine <=> [LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+)"}
{"X":52870,"RHEA_ID":51450,"compounds":"alpha-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":52871,"RHEA_ID":51451,"compounds":"chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase] <=> alpha-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52872,"RHEA_ID":52565,"compounds":"2-dehydro-L-erythronate => 3-dehydro-L-erythronate"}
{"X":52873,"RHEA_ID":61784,"compounds":"L-allulose = keto-L-fructose"}
{"X":52874,"RHEA_ID":51454,"compounds":"beta-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + ursodeoxycholate"}
{"X":52875,"RHEA_ID":51455,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + ursodeoxycholate <=> beta-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52876,"RHEA_ID":54774,"compounds":"1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + diphosphate => ATP + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide"}
{"X":52877,"RHEA_ID":51457,"compounds":"H2O + N-(9Z-octadecenoyl)-L-isoleucine => (9Z)-octadecenoate + L-isoleucine"}
{"X":52878,"RHEA_ID":51458,"compounds":"(9Z)-octadecenoate + L-isoleucine => H2O + N-(9Z-octadecenoyl)-L-isoleucine"}
{"X":52879,"RHEA_ID":51459,"compounds":"H2O + N-(9Z-octadecenoyl)-L-isoleucine <=> (9Z)-octadecenoate + L-isoleucine"}
{"X":52880,"RHEA_ID":54778,"compounds":"[LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+) => 1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine"}
{"X":52881,"RHEA_ID":61818,"compounds":"16,17-didehydropregnenolone 3-beta-D-glucoside + H(+) + UDP => 16,17-didehydropregnenolone + UDP-alpha-D-glucose"}
{"X":52882,"RHEA_ID":51462,"compounds":"(9Z)-octadecenoate + L-glutamate => H2O + N-(9Z-octadecenoyl)-L-glutamate"}
{"X":52883,"RHEA_ID":51463,"compounds":"H2O + N-(9Z-octadecenoyl)-L-glutamate <=> (9Z)-octadecenoate + L-glutamate"}
{"X":52884,"RHEA_ID":58120,"compounds":"ATP + L-seryl-[protein] = 3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate"}
{"X":52885,"RHEA_ID":61822,"compounds":"epiandrosterone 3-beta-D-glucoside + H(+) + UDP => 3beta-hydroxy-5alpha-androstan-17-one + UDP-alpha-D-glucose"}
{"X":52886,"RHEA_ID":51466,"compounds":"1beta-hydroxydeoxycholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => deoxycholate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":52887,"RHEA_ID":51467,"compounds":"deoxycholate + O2 + reduced [NADPH--hemoprotein reductase] <=> 1beta-hydroxydeoxycholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52888,"RHEA_ID":58124,"compounds":"(19S)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + polyneuridine aldehyde"}
{"X":52889,"RHEA_ID":51469,"compounds":"(R)-lactate + a quinone => a quinol + pyruvate"}
{"X":52890,"RHEA_ID":51470,"compounds":"a quinol + pyruvate => (R)-lactate + a quinone"}
{"X":52891,"RHEA_ID":52585,"DIRECTION":"LR","MASTER_ID":52584,"metacyc":"RXN-17399","compounds":"chenodeoxycholoyl-CoA + NAD(+) => 7alpha-hydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH"}
{"X":52892,"RHEA_ID":61830,"compounds":"H(+) + stigmasteryl 3-beta-D-glucoside + UDP => stigmasterol + UDP-alpha-D-glucose"}
{"X":52893,"RHEA_ID":51474,"compounds":"14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":52894,"RHEA_ID":61832,"compounds":"(24R)-ethylcholest-5-en-3beta-ol + UDP-alpha-D-glucose = H(+) + sitosteryl 3-beta-D-glucoside + UDP"}
{"X":52895,"RHEA_ID":54794,"compounds":"[nsP1 protein]-N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidine + diphosphate => 7-methyl-GTP + [nsP1 protein]-L-histidine"}
{"X":52896,"RHEA_ID":55934,"compounds":"AMP + H(+) + L-threonyl-[protein] => 3-O-(5'-adenylyl)-L-threonyl-[protein] + H2O"}
{"X":52897,"RHEA_ID":51478,"compounds":"a 2'-deoxyribonucleoside 5'-triphosphate + CO2 + H2O => a ribonucleoside 5'-triphosphate + formate + H(+)"}
{"X":52898,"RHEA_ID":61836,"compounds":"ergosterol + UDP-alpha-D-glucose = ergosteryl 3-beta-D-glucoside + H(+) + UDP"}
{"X":52899,"RHEA_ID":54798,"DIRECTION":"RL","MASTER_ID":54796,"metacyc":"RXN-18556","compounds":"an (R)-2-alkyl-3-oxoalkanoate + H(+) + NADPH => a (2R,3S)-2-alkyl-3-hydroxyalkanoate + NADP(+)"}
{"X":52900,"RHEA_ID":61838,"compounds":"ergosteryl 3-beta-D-glucoside + H(+) + UDP => ergosterol + UDP-alpha-D-glucose"}
{"X":52901,"RHEA_ID":51482,"compounds":"11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":52902,"RHEA_ID":61840,"compounds":"brassicasterol + UDP-alpha-D-glucose = brassicasterol 3-beta-D-glucoside + H(+) + UDP"}
{"X":52903,"RHEA_ID":54802,"compounds":"[nsP1 protein]-L-histidine + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA => [nsP1 protein]-N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidine + a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+)"}
{"X":52904,"RHEA_ID":61842,"compounds":"brassicasterol 3-beta-D-glucoside + H(+) + UDP => brassicasterol + UDP-alpha-D-glucose"}
{"X":52905,"RHEA_ID":51486,"compounds":"12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":52906,"RHEA_ID":51487,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52907,"RHEA_ID":54806,"DIRECTION":"RL","MASTER_ID":54804,"metacyc":"RXN-15367","compounds":"4,4'-disulfanyldibutanoate + H(+) + NADH => 2 4-sulfanylbutanoate + NAD(+)"}
{"X":52908,"RHEA_ID":61846,"compounds":"H(+) + solasodine 3-beta-D-glucoside + UDP => solasodine + UDP-alpha-D-glucose"}
{"X":52909,"RHEA_ID":51490,"compounds":"archaetidylethanolamine + CO2 => archaetidylserine + H(+)"}
{"X":52910,"RHEA_ID":51491,"compounds":"archaetidylserine + H(+) <=> archaetidylethanolamine + CO2"}
{"X":52911,"RHEA_ID":61849,"DIRECTION":"LR","MASTER_ID":61848,"metacyc":"RXN-12127","compounds":"cholesterol + UDP-alpha-D-glucose => cholesteryl 3-beta-D-glucoside + H(+) + UDP"}
{"X":52912,"RHEA_ID":61850,"compounds":"cholesteryl 3-beta-D-glucoside + H(+) + UDP => cholesterol + UDP-alpha-D-glucose"}
{"X":52913,"RHEA_ID":51494,"compounds":"all-trans-(4S)-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":52914,"RHEA_ID":51495,"compounds":"all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-(4S)-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52915,"RHEA_ID":61853,"compounds":"campesterol + UDP-alpha-D-glucose => campesteryl 3-beta-D-glucoside + H(+) + UDP"}
{"X":52916,"RHEA_ID":61854,"compounds":"campesteryl 3-beta-D-glucoside + H(+) + UDP => campesterol + UDP-alpha-D-glucose"}
{"X":52917,"RHEA_ID":51498,"compounds":"a sphingoid 1-phosphate + ADP + H(+) => a sphingoid base + ATP"}
{"X":52918,"RHEA_ID":61855,"compounds":"campesterol + UDP-alpha-D-glucose <=> campesteryl 3-beta-D-glucoside + H(+) + UDP"}
{"X":52919,"RHEA_ID":61857,"compounds":"dehydroprobetaenone I + 3 H(+) + 3 NADPH + 3 O2 => betaenone C + 3 H2O + 3 NADP(+)"}
{"X":52920,"RHEA_ID":61858,"compounds":"betaenone C + 3 H2O + 3 NADP(+) => dehydroprobetaenone I + 3 H(+) + 3 NADPH + 3 O2"}
{"X":52921,"RHEA_ID":51502,"compounds":"ADP + H(+) + N-acetyl-D-muramate 6-phosphate => ATP + N-acetyl-D-muramate"}
{"X":52922,"RHEA_ID":61860,"compounds":"dehydroprobetaenone I + H(+) + NADPH + O2 = epoxybetaenone + H2O + NADP(+)"}
{"X":52923,"RHEA_ID":61861,"compounds":"dehydroprobetaenone I + H(+) + NADPH + O2 => epoxybetaenone + H2O + NADP(+)"}
{"X":52924,"RHEA_ID":61862,"compounds":"epoxybetaenone + H2O + NADP(+) => dehydroprobetaenone I + H(+) + NADPH + O2"}
{"X":52925,"RHEA_ID":51506,"compounds":"a 3'-(beta-D-glucopyranosyl)-2'-hydroxy-beta-oxodihydrochalcone + H(+) + UDP => a 3'-hydro-2'-hydroxy-beta-oxodihydrochalcone + UDP-alpha-D-glucose"}
{"X":52926,"RHEA_ID":61863,"compounds":"dehydroprobetaenone I + H(+) + NADPH + O2 <=> epoxybetaenone + H2O + NADP(+)"}
{"X":52927,"RHEA_ID":61865,"compounds":"AH2 + dehydroprobetaenone I => A + probetaenone I"}
{"X":52928,"RHEA_ID":61866,"compounds":"A + probetaenone I => AH2 + dehydroprobetaenone I"}
{"X":52929,"RHEA_ID":58166,"compounds":"7-epi-ent-eudesmane-5,11-diol + diphosphate => (2E,6E)-farnesyl diphosphate + 2 H2O"}
{"X":52930,"RHEA_ID":54829,"compounds":"dimethylamine + H(+) + NADPH + O2 => formaldehyde + H2O + methylamine + NADP(+)"}
{"X":52931,"RHEA_ID":61869,"compounds":"1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl-(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatrienoate"}
{"X":52932,"RHEA_ID":61870,"compounds":"1-O-methyl-(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatrienoate => 1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2"}
{"X":52933,"RHEA_ID":51514,"compounds":"NH4(+) + oxalate => H2O + oxamate"}
{"X":52934,"RHEA_ID":54833,"DIRECTION":"LR","MASTER_ID":54832,"metacyc":"RXN-18489","compounds":"a jasmonyl-L-amino acid + O2 + reduced [NADPH--hemoprotein reductase] => a 12-hydroxyjasmonyl-L-alpha-amino acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52935,"RHEA_ID":51516,"DIRECTION":"UN","MASTER_ID":51516,"ec":"2.1.1.337","compounds":"(R)-reticuline + S-adenosyl-L-methionine = (R)-tembetarine + H(+) + S-adenosyl-L-homocysteine"}
{"X":52936,"RHEA_ID":61874,"compounds":"1-O-methyl-(9R)-hydroperoxy-(10E,12Z)-octadecadienoate => 1-O-methyl-(9Z,12Z)-octadecadienoate + O2"}
{"X":52937,"RHEA_ID":61875,"compounds":"1-O-methyl-(9Z,12Z)-octadecadienoate + O2 <=> 1-O-methyl-(9R)-hydroperoxy-(10E,12Z)-octadecadienoate"}
{"X":52938,"RHEA_ID":53730,"compounds":"N-acetyl-D-muramate + phosphate => H2O + N-acetyl-D-muramate 6-phosphate"}
{"X":52939,"RHEA_ID":52633,"DIRECTION":"LR","MASTER_ID":52632,"metacyc":"RXN-15005","compounds":"[amino group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ATP => [amino group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + ADP"}
{"X":52940,"RHEA_ID":51521,"DIRECTION":"LR","MASTER_ID":51520,"metacyc":"RXN-18426","compounds":"(S)-reticuline + S-adenosyl-L-methionine => (S)-tembetarine + H(+) + S-adenosyl-L-homocysteine"}
{"X":52941,"RHEA_ID":61879,"compounds":"1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl-8-hydroperoxy-20-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate"}
{"X":52942,"RHEA_ID":55980,"DIRECTION":"UN","MASTER_ID":55980,"ec":"2.3.3.20","compounds":"1,2-saturated acyl-CoA + an acyl-CoA + H2O = an (R)-2-alkyl-3-oxoalkanoate + 2 CoA + H(+)"}
{"X":52943,"RHEA_ID":51524,"DIRECTION":"UN","MASTER_ID":51524,"ec":"2.1.1.337","compounds":"(S)-corytuberine + S-adenosyl-L-methionine = magnoflorine + S-adenosyl-L-homocysteine"}
{"X":52944,"RHEA_ID":51525,"DIRECTION":"LR","MASTER_ID":51524,"metacyc":"RXN-9315","compounds":"(S)-corytuberine + S-adenosyl-L-methionine => magnoflorine + S-adenosyl-L-homocysteine"}
{"X":52945,"RHEA_ID":57071,"compounds":"3-oxo-isoapionate + ATP <=> 3-oxo-isoapionate 4-phosphate + ADP + H(+)"}
{"X":52946,"RHEA_ID":61882,"compounds":"1-O-methyl-12-hydroperoxy-20-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => 1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2"}
{"X":52947,"RHEA_ID":51528,"compounds":"4-hydroxy-3-methoxybenzoate + H(+) = CO2 + guaiacol"}
{"X":52948,"RHEA_ID":59330,"compounds":"D-xylonate + H(+) => D-xylono-1,5-lactone + H2O"}
{"X":52949,"RHEA_ID":51530,"compounds":"CO2 + guaiacol => 4-hydroxy-3-methoxybenzoate + H(+)"}
{"X":52950,"RHEA_ID":58187,"compounds":"H(+) + NADPH + 2 phytyl diphosphate <=> (14E,18E)-lycopadiene + 2 diphosphate + NADP(+)"}
{"X":52951,"RHEA_ID":51532,"compounds":"H(+) + NADPH + O2 + urate = 5-hydroxyisourate + H2O + NADP(+)"}
{"X":52952,"RHEA_ID":51533,"compounds":"H(+) + NADPH + O2 + urate => 5-hydroxyisourate + H2O + NADP(+)"}
{"X":52953,"RHEA_ID":54852,"compounds":"H(+) + heptan-4-one + NADPH + O2 = H2O + NADP(+) + propyl butanoate"}
{"X":52954,"RHEA_ID":58191,"compounds":"all-trans-lycopene + dimethylallyl diphosphate + H2O <=> dihydroisopentenyldehydrorhodopin + diphosphate"}
{"X":52955,"RHEA_ID":51536,"compounds":"L-tyrosyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-L-tyrosyl-[protein] + UDP"}
{"X":52956,"RHEA_ID":51537,"compounds":"L-tyrosyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-L-tyrosyl-[protein] + UDP"}
{"X":52957,"RHEA_ID":61899,"compounds":"betaenone C <=> betaenone A"}
{"X":52958,"RHEA_ID":61900,"compounds":"AH2 + betaenone C = A + betaenone B"}
{"X":52959,"RHEA_ID":51540,"DIRECTION":"UN","MASTER_ID":51540,"ec":"1.14.19.51","compounds":"(S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] = (S)-corytuberine + 2 H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52960,"RHEA_ID":51541,"DIRECTION":"LR","MASTER_ID":51540,"metacyc":"RXN-9314","compounds":"(S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] => (S)-corytuberine + 2 H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":52961,"RHEA_ID":61903,"compounds":"AH2 + betaenone C <=> A + betaenone B"}
{"X":52962,"RHEA_ID":61904,"compounds":"betaenone A + H(+) + NADPH + O2 = H2O + NADP(+) + stemphyloxin II"}
{"X":52963,"RHEA_ID":61905,"compounds":"betaenone A + H(+) + NADPH + O2 => H2O + NADP(+) + stemphyloxin II"}
{"X":52964,"RHEA_ID":51545,"compounds":"D-ribulose => D-xylulose"}
{"X":52965,"RHEA_ID":61907,"compounds":"betaenone A + H(+) + NADPH + O2 <=> H2O + NADP(+) + stemphyloxin II"}
{"X":52966,"RHEA_ID":61908,"compounds":"2 ATP + benzoate + L-phenylalanine + N-benzoyl-L-phenylalaninol = 2 AMP + asperphenamate + 2 diphosphate + H(+)"}
{"X":52967,"RHEA_ID":61909,"compounds":"2 ATP + benzoate + L-phenylalanine + N-benzoyl-L-phenylalaninol => 2 AMP + asperphenamate + 2 diphosphate + H(+)"}
{"X":52968,"RHEA_ID":51549,"compounds":"(R)-tetrahydropapaverine + S-adenosyl-L-methionine => (R)-N-methyltetrahydropapaverine + H(+) + S-adenosyl-L-homocysteine"}
{"X":52969,"RHEA_ID":51550,"compounds":"(R)-N-methyltetrahydropapaverine + H(+) + S-adenosyl-L-homocysteine => (R)-tetrahydropapaverine + S-adenosyl-L-methionine"}
{"X":52970,"RHEA_ID":51551,"compounds":"(R)-tetrahydropapaverine + S-adenosyl-L-methionine <=> (R)-N-methyltetrahydropapaverine + H(+) + S-adenosyl-L-homocysteine"}
{"X":52971,"RHEA_ID":61913,"compounds":"ATP + H2O + voriconazole(in) => ADP + H(+) + phosphate + voriconazole(out)"}
{"X":52972,"RHEA_ID":51553,"compounds":"D-sorbitol + NADP(+) => H(+) + L-xylo-3-hexulose + NADPH"}
{"X":52973,"RHEA_ID":61915,"compounds":"ATP + H2O + voriconazole(in) <=> ADP + H(+) + phosphate + voriconazole(out)"}
{"X":52974,"RHEA_ID":61916,"compounds":"ATP + fluconazole(in) + H2O = ADP + fluconazole(out) + H(+) + phosphate"}
{"X":52975,"RHEA_ID":61917,"compounds":"ATP + fluconazole(in) + H2O => ADP + fluconazole(out) + H(+) + phosphate"}
{"X":52976,"RHEA_ID":51557,"compounds":"(S)-glaucine + S-adenosyl-L-methionine => (S)-N-methylglaucine + H(+) + S-adenosyl-L-homocysteine"}
{"X":52977,"RHEA_ID":61919,"compounds":"ATP + fluconazole(in) + H2O <=> ADP + fluconazole(out) + H(+) + phosphate"}
{"X":52978,"RHEA_ID":61920,"compounds":"(2R,4S)-ketoconazole(in) + ATP + H2O = (2R,4S)-ketoconazole(out) + ADP + H(+) + phosphate"}
{"X":52979,"RHEA_ID":61921,"compounds":"(2R,4S)-ketoconazole(in) + ATP + H2O => (2R,4S)-ketoconazole(out) + ADP + H(+) + phosphate"}
{"X":52980,"RHEA_ID":58217,"compounds":"A + dihydroserpentine => AH2 + serpentine"}
{"X":52981,"RHEA_ID":61923,"compounds":"(2R,4S)-ketoconazole(in) + ATP + H2O <=> (2R,4S)-ketoconazole(out) + ADP + H(+) + phosphate"}
{"X":52982,"RHEA_ID":61924,"compounds":"(2S,4R)-ketoconazole(in) + ATP + H2O = (2S,4R)-ketoconazole(out) + ADP + H(+) + phosphate"}
{"X":52983,"RHEA_ID":61925,"compounds":"(2S,4R)-ketoconazole(in) + ATP + H2O => (2S,4R)-ketoconazole(out) + ADP + H(+) + phosphate"}
{"X":52984,"RHEA_ID":58221,"compounds":"L-lysyl-[protein] + NAD(+) => H(+) + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide"}
{"X":52985,"RHEA_ID":61927,"compounds":"(2S,4R)-ketoconazole(in) + ATP + H2O <=> (2S,4R)-ketoconazole(out) + ADP + H(+) + phosphate"}
{"X":52986,"RHEA_ID":58223,"compounds":"L-lysyl-[protein] + NAD(+) <=> H(+) + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide"}
{"X":52987,"RHEA_ID":61929,"compounds":"(R)-miconazole(in) + ATP + H2O => (R)-miconazole(out) + ADP + H(+) + phosphate"}
{"X":52988,"RHEA_ID":51569,"DIRECTION":"LR","MASTER_ID":51568,"metacyc":"RXN-12850","compounds":"(25S)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (25S)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":52989,"RHEA_ID":61931,"compounds":"(R)-miconazole(in) + ATP + H2O <=> (R)-miconazole(out) + ADP + H(+) + phosphate"}
{"X":52990,"RHEA_ID":61932,"compounds":"(S)-miconazole(in) + ATP + H2O = (S)-miconazole(out) + ADP + H(+) + phosphate"}
{"X":52991,"RHEA_ID":61933,"compounds":"(S)-miconazole(in) + ATP + H2O => (S)-miconazole(out) + ADP + H(+) + phosphate"}
{"X":52992,"RHEA_ID":54891,"compounds":"ATP + CoA + OPC-8 <=> AMP + diphosphate + OPC-8-CoA"}
{"X":52993,"RHEA_ID":61934,"compounds":"(S)-miconazole(out) + ADP + H(+) + phosphate => (S)-miconazole(in) + ATP + H2O"}
{"X":52994,"RHEA_ID":54893,"DIRECTION":"LR","MASTER_ID":54892,"metacyc":"RXN-19050","compounds":"[LarE protein]-L-cysteine + ATP + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide => [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide"}
{"X":52995,"RHEA_ID":51576,"DIRECTION":"UN","MASTER_ID":51576,"ec":"2.4.1.357","compounds":"phloretin + UDP-alpha-D-glucose = H(+) + phlorizin + UDP"}
{"X":52996,"RHEA_ID":54895,"compounds":"[LarE protein]-L-cysteine + ATP + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide <=> [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide"}
{"X":52997,"RHEA_ID":61939,"compounds":"ATP + cycloheximide(in) + H2O <=> ADP + cycloheximide(out) + H(+) + phosphate"}
{"X":52998,"RHEA_ID":58235,"compounds":"L-seryl-[protein] + NAD(+) <=> H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein]"}
{"X":52999,"RHEA_ID":51580,"compounds":"a fatty acid(out) + ATP(in) + CoA(in) + H(+)(out) = AMP(in) + an acyl-CoA(in) + diphosphate(in) + H(+)(in)"}
{"X":53000,"RHEA_ID":61942,"compounds":"3beta-hydroxy-16alpha,17alpha-epoxypregnenolone 3-beta-D-glucoside + H(+) + UDP => 3beta-hydroxy-16alpha,17alpha-epoxypregnenolone + UDP-alpha-D-glucose"}
{"X":53001,"RHEA_ID":61943,"compounds":"3beta-hydroxy-16alpha,17alpha-epoxypregnenolone + UDP-alpha-D-glucose <=> 3beta-hydroxy-16alpha,17alpha-epoxypregnenolone 3-beta-D-glucoside + H(+) + UDP"}
{"X":53002,"RHEA_ID":51583,"compounds":"a fatty acid(out) + ATP(in) + CoA(in) + H(+)(out) <=> AMP(in) + an acyl-CoA(in) + diphosphate(in) + H(+)(in)"}
{"X":53003,"RHEA_ID":61945,"compounds":"24-methylenecholesterol + UDP-alpha-D-glucose => 24-methylene cholesteryl beta-D-glucoside + H(+) + UDP"}
{"X":53004,"RHEA_ID":54903,"compounds":"(2E)-hexadecenoyl-[ACP] + H(+) + NADH <=> hexadecanoyl-[ACP] + NAD(+)"}
{"X":53005,"RHEA_ID":61947,"compounds":"24-methylenecholesterol + UDP-alpha-D-glucose <=> 24-methylene cholesteryl beta-D-glucoside + H(+) + UDP"}
{"X":53006,"RHEA_ID":61948,"compounds":"2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl-[protein] + O2 = CO2 + formaldehyde + N(6)-methyl-L-lysyl-[protein] + succinate"}
{"X":53007,"RHEA_ID":51588,"DIRECTION":"UN","MASTER_ID":51588,"ec":"1.1.1.416","compounds":"isopyridoxal + NAD(+) = 5-pyridoxolactone + H(+) + NADH"}
{"X":53008,"RHEA_ID":61950,"compounds":"CO2 + formaldehyde + N(6)-methyl-L-lysyl-[protein] + succinate => 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl-[protein] + O2"}
{"X":53009,"RHEA_ID":59390,"compounds":"a fatty acid + an aliphatic alcohol + H(+) => a fatty acid ester + H2O"}
{"X":53010,"RHEA_ID":61952,"compounds":"2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + O2 = CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl-[protein] + succinate"}
{"X":53011,"RHEA_ID":61953,"compounds":"2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + O2 => CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl-[protein] + succinate"}
{"X":53012,"RHEA_ID":61954,"compounds":"CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl-[protein] + succinate => 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + O2"}
{"X":53013,"RHEA_ID":59394,"compounds":"CoA + O-acetyl-L-seryl-[protein] => acetyl-CoA + L-seryl-[protein]"}
{"X":53014,"RHEA_ID":61957,"compounds":"1-O-octadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + AH2 + O2 => 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + A + 2 H2O"}
{"X":53015,"RHEA_ID":58253,"compounds":"H2O + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] => ADP-D-ribose + L-asparaginyl-[protein]"}
{"X":53016,"RHEA_ID":51598,"compounds":"4-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + p-xylene + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":53017,"RHEA_ID":61960,"compounds":"a 1-O-hexadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + AH2 + O2 = A + a 1-O-(1Z-hexadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 H2O"}
{"X":53018,"RHEA_ID":51600,"DIRECTION":"UN","MASTER_ID":51600,"ec":"1.14.15.26","compounds":"2 H(+) + m-xylene + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":53019,"RHEA_ID":61962,"compounds":"A + a 1-O-(1Z-hexadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 H2O => a 1-O-hexadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + AH2 + O2"}
{"X":53020,"RHEA_ID":51602,"compounds":"3-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + m-xylene + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":53021,"RHEA_ID":56060,"DIRECTION":"UN","MASTER_ID":56060,"ec":"4.1.1.106","compounds":"H(+) + hexadecanoate + hnu = CO2 + pentadecane"}
{"X":53022,"RHEA_ID":51604,"DIRECTION":"UN","MASTER_ID":51604,"ec":"1.14.15.25","compounds":"2 H(+) + O2 + p-cymene + 2 reduced [2Fe-2S]-[ferredoxin] = 4-isopropylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":53023,"RHEA_ID":61966,"compounds":"A + a 1-O-(1Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 H2O => a 1-O-octadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + AH2 + O2"}
{"X":53024,"RHEA_ID":51606,"compounds":"4-isopropylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + p-cymene + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":53025,"RHEA_ID":56064,"DIRECTION":"UN","MASTER_ID":56064,"ec":"2.4.2.n2","metacyc":"RXN-11242","compounds":"3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP"}
{"X":53026,"RHEA_ID":51608,"DIRECTION":"UN","MASTER_ID":51608,"ec":"1.1.99.40","compounds":"(R)-2-hydroxyglutarate + pyruvate = (R)-lactate + 2-oxoglutarate"}
{"X":53027,"RHEA_ID":51609,"compounds":"(R)-2-hydroxyglutarate + pyruvate => (R)-lactate + 2-oxoglutarate"}
{"X":53028,"RHEA_ID":61971,"compounds":"a 1-O-(9Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + AH2 + O2 <=> A + a 1-O-(1Z,9Z-octadecadienyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 H2O"}
{"X":53029,"RHEA_ID":51611,"DIRECTION":"BI","MASTER_ID":51608,"metacyc":"RXN-18432","compounds":"(R)-2-hydroxyglutarate + pyruvate <=> (R)-lactate + 2-oxoglutarate"}
{"X":53030,"RHEA_ID":51612,"DIRECTION":"UN","MASTER_ID":51612,"ec":"1.1.99.40","compounds":"(R)-2-hydroxyglutarate + oxaloacetate = (R)-malate + 2-oxoglutarate"}
{"X":53031,"RHEA_ID":51613,"compounds":"(R)-2-hydroxyglutarate + oxaloacetate => (R)-malate + 2-oxoglutarate"}
{"X":53032,"RHEA_ID":61975,"compounds":"1-O-(13-methyltetradecyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + AH2 + O2 <=> 1-O-(1Z-13-methyltetradecenyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + A + 2 H2O"}
{"X":53033,"RHEA_ID":56071,"compounds":"an N-acetyl-alpha-D-glucosaminyl derivative + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl derivative + H(+) + UDP"}
{"X":53034,"RHEA_ID":51616,"compounds":"ATP + formate + H(+) = CO2 + dATP + H2O"}
{"X":53035,"RHEA_ID":51617,"DIRECTION":"LR","MASTER_ID":51616,"ecocyc":"RXN0-745","metacyc":"RXN0-745","compounds":"ATP + formate + H(+) => CO2 + dATP + H2O"}
{"X":53036,"RHEA_ID":61978,"compounds":"5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin] => glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine"}
{"X":53037,"RHEA_ID":60681,"compounds":"(+)-artemisinic aldehyde + H2O + NADP(+) => (+)-artemisinate + 2 H(+) + NADPH"}
{"X":53038,"RHEA_ID":51620,"compounds":"CTP + formate + H(+) = CO2 + dCTP + H2O"}
{"X":53039,"RHEA_ID":51621,"DIRECTION":"LR","MASTER_ID":51620,"ecocyc":"RXN0-723","metacyc":"RXN0-723","compounds":"CTP + formate + H(+) => CO2 + dCTP + H2O"}
{"X":53040,"RHEA_ID":54940,"compounds":"(3Z)-decenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(5Z)-dodecenoyl-[ACP] + CO2 + holo-[ACP]"}
{"X":53041,"RHEA_ID":54941,"compounds":"(3Z)-decenoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxo-(5Z)-dodecenoyl-[ACP] + CO2 + holo-[ACP]"}
{"X":53042,"RHEA_ID":51624,"compounds":"formate + GTP + H(+) = CO2 + dGTP + H2O"}
{"X":53043,"RHEA_ID":51625,"DIRECTION":"LR","MASTER_ID":51624,"ecocyc":"RXN0-746","metacyc":"RXN0-746","compounds":"formate + GTP + H(+) => CO2 + dGTP + H2O"}
{"X":53044,"RHEA_ID":54944,"compounds":"3-oxo-(5Z)-dodecenoyl-[ACP] + H(+) + NADPH = (3R)-hydroxy-(5Z)-dodecenoyl-[ACP] + NADP(+)"}
{"X":53045,"RHEA_ID":54945,"compounds":"3-oxo-(5Z)-dodecenoyl-[ACP] + H(+) + NADPH => (3R)-hydroxy-(5Z)-dodecenoyl-[ACP] + NADP(+)"}
{"X":53046,"RHEA_ID":51628,"compounds":"formate + H(+) + UTP = CO2 + dUTP + H2O"}
{"X":53047,"RHEA_ID":51629,"DIRECTION":"LR","MASTER_ID":51628,"ecocyc":"RXN0-724","metacyc":"RXN0-724","compounds":"formate + H(+) + UTP => CO2 + dUTP + H2O"}
{"X":53048,"RHEA_ID":59438,"compounds":"4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AMP + diphosphate => 4-amino-L-phenylalanine + ATP + holo-[peptidyl-carrier protein]"}
{"X":53049,"RHEA_ID":56087,"compounds":"[Rab1 protein]-O-phosphocholine-L-serine + H2O <=> [Rab1 protein]-L-serine + H(+) + phosphocholine"}
{"X":53050,"RHEA_ID":51632,"compounds":"all-trans-(4S)-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-(4S,16)-dihydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53051,"RHEA_ID":51633,"compounds":"all-trans-(4S)-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-(4S,16)-dihydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53052,"RHEA_ID":58294,"compounds":"25-substituted-cholesteryl beta-D-glucoside + N-dodecanoylsphing-4-enine => 25-substituted-cholesterol + beta-D-glucosyl-N-dodecanoylsphing-4E-enine"}
{"X":53053,"RHEA_ID":61996,"compounds":"L-lysyl-[protein] + lactoyl-CoA = CoA + H(+) + N(6)-lactoyl-L-lysyl-[protein]"}
{"X":53054,"RHEA_ID":51636,"compounds":"a quinone + H2O + selenite = a quinol + selenate"}
{"X":53055,"RHEA_ID":51637,"compounds":"a quinone + H2O + selenite => a quinol + selenate"}
{"X":53056,"RHEA_ID":61998,"compounds":"CoA + H(+) + N(6)-lactoyl-L-lysyl-[protein] => L-lysyl-[protein] + lactoyl-CoA"}
{"X":53057,"RHEA_ID":62000,"compounds":"3 A + protoporphyrinogen IX = 3 AH2 + protoporphyrin IX"}
{"X":53058,"RHEA_ID":51640,"compounds":"(9Z,12Z)-octadecadienoate + O2 = (11R)-hydroperoxy-(9Z,12Z)-octadecadienoate"}
{"X":53059,"RHEA_ID":51641,"compounds":"(9Z,12Z)-octadecadienoate + O2 => (11R)-hydroperoxy-(9Z,12Z)-octadecadienoate"}
{"X":53060,"RHEA_ID":58302,"compounds":"25-substituted-cholesteryl beta-D-glucoside + N-octadecanoylsphing-4-enine => 25-substituted-cholesterol + beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine"}
{"X":53061,"RHEA_ID":51643,"compounds":"(9Z,12Z)-octadecadienoate + O2 <=> (11R)-hydroperoxy-(9Z,12Z)-octadecadienoate"}
{"X":53062,"RHEA_ID":51644,"DIRECTION":"UN","MASTER_ID":51644,"ec":"1.14.19.21","compounds":"cholesterol + H(+) + NADH + O2 = cholesta-5,7-dien-3beta-ol + 2 H2O + NAD(+)"}
{"X":53063,"RHEA_ID":51645,"DIRECTION":"LR","MASTER_ID":51644,"metacyc":"RXN-16379","compounds":"cholesterol + H(+) + NADH + O2 => cholesta-5,7-dien-3beta-ol + 2 H2O + NAD(+)"}
{"X":53064,"RHEA_ID":62006,"compounds":"an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc6S derivative + GDP + H(+) => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc6S derivative + GDP-beta-L-fucose"}
{"X":53065,"RHEA_ID":62008,"compounds":"alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose = alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP + H(+)"}
{"X":53066,"RHEA_ID":51648,"compounds":"H2O + N(6)-acetyl-L-lysyl-[protein] + O2 = [protein]-(S)-2-amino-6-oxohexanoate + acetamide + H2O2"}
{"X":53067,"RHEA_ID":62010,"compounds":"alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP + H(+) => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose"}
{"X":53068,"RHEA_ID":59458,"compounds":"H(+) + NADPH + tetradecanal => NADP(+) + tetradecan-1-ol"}
{"X":53069,"RHEA_ID":51651,"compounds":"H2O + N(6)-acetyl-L-lysyl-[protein] + O2 <=> [protein]-(S)-2-amino-6-oxohexanoate + acetamide + H2O2"}
{"X":53070,"RHEA_ID":51652,"DIRECTION":"UN","MASTER_ID":51652,"ec":"1.1.1.57","compounds":"D-mannonate + NAD(+) = H(+) + keto-D-tagaturonate + NADH"}
{"X":53071,"RHEA_ID":62014,"compounds":"5-methylcytidine(2499) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(2499) in 23S rRNA + S-adenosyl-L-methionine"}
{"X":53072,"RHEA_ID":53869,"compounds":"2 H(+) + NADH + O2 + phenazine-1-carboxylate => 1-hydroxyphenazine + CO2 + H2O + NAD(+)"}
{"X":53073,"RHEA_ID":59463,"compounds":"hexadecan-1-ol + NADP(+) <=> H(+) + hexadecanal + NADPH"}
{"X":53074,"RHEA_ID":51656,"DIRECTION":"UN","MASTER_ID":51656,"ec":"5.1.2.7","compounds":"keto-D-tagaturonate = keto-D-fructuronate"}
{"X":53075,"RHEA_ID":51657,"DIRECTION":"LR","MASTER_ID":51656,"metacyc":"RXN-14362","compounds":"keto-D-tagaturonate => keto-D-fructuronate"}
{"X":53076,"RHEA_ID":62018,"compounds":"3-O-(beta-D-xylosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP => L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose"}
{"X":53077,"RHEA_ID":62020,"compounds":"H2O + sitosteryl 3-beta-D-glucoside = (24R)-ethylcholest-5-en-3beta-ol + D-glucose"}
{"X":53078,"RHEA_ID":51660,"compounds":"an N-(1,2-saturated acyl)sphinganine + H(+) + NADPH + O2 = an N-(2-hydroxyacyl)-sphinganine + H2O + NADP(+)"}
{"X":53079,"RHEA_ID":62022,"compounds":"(24R)-ethylcholest-5-en-3beta-ol + D-glucose => H2O + sitosteryl 3-beta-D-glucoside"}
{"X":53080,"RHEA_ID":62023,"compounds":"H2O + sitosteryl 3-beta-D-glucoside <=> (24R)-ethylcholest-5-en-3beta-ol + D-glucose"}
{"X":53081,"RHEA_ID":51663,"compounds":"an N-(1,2-saturated acyl)sphinganine + H(+) + NADPH + O2 <=> an N-(2-hydroxyacyl)-sphinganine + H2O + NADP(+)"}
{"X":53082,"RHEA_ID":51664,"compounds":"D-5-phenylhydantoin + H2O = H(+) + N-carbamoyl-D-phenylglycine"}
{"X":53083,"RHEA_ID":62026,"compounds":"campesterol + D-glucose => campesteryl 3-beta-D-glucoside + H2O"}
{"X":53084,"RHEA_ID":53881,"DIRECTION":"LR","MASTER_ID":53880,"metacyc":"RXN-761","compounds":"ADP-alpha-D-glucose + D-glucose 6-phosphate => ADP + alpha,alpha-trehalose 6-phosphate + H(+)"}
{"X":53085,"RHEA_ID":56123,"compounds":"2-all-trans-heptaprenylphenol + H(+) + NADPH + O2 <=> 3-(all-trans-heptaprenyl)benzene-1,2-diol + H2O + NADP(+)"}
{"X":53086,"RHEA_ID":51668,"compounds":"H(+) + mevastatin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2 oxidized [2Fe-2S]-[ferredoxin] + pravastatin"}
{"X":53087,"RHEA_ID":62030,"compounds":"D-glucose + stigmasterol => H2O + stigmasteryl 3-beta-D-glucoside"}
{"X":53088,"RHEA_ID":62031,"compounds":"H2O + stigmasteryl 3-beta-D-glucoside <=> D-glucose + stigmasterol"}
{"X":53089,"RHEA_ID":51671,"compounds":"H(+) + mevastatin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 oxidized [2Fe-2S]-[ferredoxin] + pravastatin"}
{"X":53090,"RHEA_ID":62033,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoglycerol + H2O => a 2-acyl-sn-glycero-3-phosphoglycerol + a fatty acid + H(+)"}
{"X":53091,"RHEA_ID":51673,"DIRECTION":"LR","MASTER_ID":51672,"ecocyc":"RXN0-7173","metacyc":"RXN0-7173","compounds":"glyoxal + H2O => glycolate + H(+)"}
{"X":53092,"RHEA_ID":62035,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoglycerol + H2O <=> a 2-acyl-sn-glycero-3-phosphoglycerol + a fatty acid + H(+)"}
{"X":53093,"RHEA_ID":51675,"compounds":"glyoxal + H2O <=> glycolate + H(+)"}
{"X":53094,"RHEA_ID":51676,"compounds":"[protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide = [protein]-dithiol + 2 AH2 + H(+) + sulfite"}
{"X":53095,"RHEA_ID":58337,"compounds":"a 4-hydroxynonen-1-ol + NADP(+) => a 4-hydroxynonenal + H(+) + NADPH"}
{"X":53096,"RHEA_ID":62039,"compounds":"a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O <=> a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)"}
{"X":53097,"RHEA_ID":51679,"compounds":"[protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide <=> [protein]-dithiol + 2 AH2 + H(+) + sulfite"}
{"X":53098,"RHEA_ID":58340,"compounds":"beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose"}
{"X":53099,"RHEA_ID":51682,"compounds":"(2E,6E)-farnesyl phosphate + CDP + H(+) => (2E,6E)-farnesol + CTP"}
{"X":53100,"RHEA_ID":55001,"compounds":"3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine => 3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n+1)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP"}
{"X":53101,"RHEA_ID":51684,"DIRECTION":"UN","MASTER_ID":51684,"ec":"2.7.4.32","compounds":"(2E,6E)-farnesyl phosphate + CTP = (2E,6E)-farnesyl diphosphate + CDP"}
{"X":53102,"RHEA_ID":62046,"compounds":"(9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphoglycerol + H(+) => a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphoglycerol + H2O"}
{"X":53103,"RHEA_ID":51686,"compounds":"(2E,6E)-farnesyl diphosphate + CDP => (2E,6E)-farnesyl phosphate + CTP"}
{"X":53104,"RHEA_ID":62048,"compounds":"an N-aryl-1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O = an N-aryl-1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate"}
{"X":53105,"RHEA_ID":51688,"DIRECTION":"UN","MASTER_ID":51688,"ec":"1.1.1.406","compounds":"galactitol + NAD(+) = H(+) + keto-L-tagatose + NADH"}
{"X":53106,"RHEA_ID":62050,"compounds":"an N-aryl-1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate => an N-aryl-1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O"}
{"X":53107,"RHEA_ID":62051,"compounds":"an N-aryl-1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O <=> an N-aryl-1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate"}
{"X":53108,"RHEA_ID":55009,"DIRECTION":"LR","MASTER_ID":55008,"metacyc":"RXN-15255","compounds":"(1R,4S)-1-hydroxylimonen-2-one + NADPH + O2 => (3S)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)"}
{"X":53109,"RHEA_ID":51692,"compounds":"prephenate + S-adenosyl-L-methionine = 3-phenylpyruvate + carboxy-S-adenosyl-L-methionine + H2O"}
{"X":53110,"RHEA_ID":62054,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+) => a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphate + H2O"}
{"X":53111,"RHEA_ID":62055,"compounds":"a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphate + H2O <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)"}
{"X":53112,"RHEA_ID":51695,"compounds":"prephenate + S-adenosyl-L-methionine <=> 3-phenylpyruvate + carboxy-S-adenosyl-L-methionine + H2O"}
{"X":53113,"RHEA_ID":58356,"compounds":"2-oxoglutarate + N(omega)-methyl-L-arginyl-[protein] + O2 = CO2 + formaldehyde + L-arginyl-[protein] + succinate"}
{"X":53114,"RHEA_ID":62058,"compounds":"alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+) => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose"}
{"X":53115,"RHEA_ID":51698,"compounds":"H(+) + S-adenosyl-L-homocysteine + xanthohumol => desmethylxanthohumol + S-adenosyl-L-methionine"}
{"X":53116,"RHEA_ID":62060,"compounds":"alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose = alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+)"}
{"X":53117,"RHEA_ID":51700,"DIRECTION":"UN","MASTER_ID":51700,"ec":"2.1.1.338","compounds":"S-adenosyl-L-methionine + xanthogalenol = 4'-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine"}
{"X":53118,"RHEA_ID":62062,"compounds":"alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+) => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose"}
{"X":53119,"RHEA_ID":62063,"compounds":"alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose <=> alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+)"}
{"X":53120,"RHEA_ID":51703,"compounds":"S-adenosyl-L-methionine + xanthogalenol <=> 4'-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine"}
{"X":53121,"RHEA_ID":51704,"DIRECTION":"UN","MASTER_ID":51704,"ec":"2.1.1.339","compounds":"S-adenosyl-L-methionine + xanthohumol = 4-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine"}
{"X":53122,"RHEA_ID":51705,"DIRECTION":"LR","MASTER_ID":51704,"metacyc":"RXN-18475","compounds":"S-adenosyl-L-methionine + xanthohumol => 4-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine"}
{"X":53123,"RHEA_ID":55024,"DIRECTION":"UN","MASTER_ID":55024,"ec":"1.14.14.50","compounds":"(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] = (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53124,"RHEA_ID":51707,"compounds":"S-adenosyl-L-methionine + xanthohumol <=> 4-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine"}
{"X":53125,"RHEA_ID":55026,"compounds":"(3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":53126,"RHEA_ID":51709,"DIRECTION":"LR","MASTER_ID":51708,"metacyc":"RXN-18474","compounds":"D-altritol + NAD(+) => H(+) + keto-D-tagatose + NADH"}
{"X":53127,"RHEA_ID":62071,"compounds":"2-deoxy-D-glucose 6-phosphate + NADP(+) <=> 2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADPH"}
{"X":53128,"RHEA_ID":55029,"DIRECTION":"LR","MASTER_ID":55028,"metacyc":"RXN-18674","compounds":"an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + S-adenosyl-L-methionine => an N-methylornithine lipid + H(+) + S-adenosyl-L-homocysteine"}
{"X":53129,"RHEA_ID":55030,"compounds":"an N-methylornithine lipid + H(+) + S-adenosyl-L-homocysteine => an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + S-adenosyl-L-methionine"}
{"X":53130,"RHEA_ID":52828,"compounds":"(1S,4R)-isodihydrocarvone + H(+) + NADPH + O2 = (3S,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)"}
{"X":53131,"RHEA_ID":55032,"compounds":"an N-methylornithine lipid + S-adenosyl-L-methionine = an N,N-dimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine"}
{"X":53132,"RHEA_ID":55033,"DIRECTION":"LR","MASTER_ID":55032,"metacyc":"RXN-18675","compounds":"an N-methylornithine lipid + S-adenosyl-L-methionine => an N,N-dimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine"}
{"X":53133,"RHEA_ID":55034,"compounds":"an N,N-dimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine => an N-methylornithine lipid + S-adenosyl-L-methionine"}
{"X":53134,"RHEA_ID":56173,"DIRECTION":"LR","MASTER_ID":56172,"metacyc":"RXN-18509","compounds":"FMN + O2 => 8-demethyl-8-formylriboflavin 5'-phosphate + H2O"}
{"X":53135,"RHEA_ID":55036,"compounds":"an N,N-dimethylornithine lipid + S-adenosyl-L-methionine = an N,N,N-trimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine"}
{"X":53136,"RHEA_ID":51719,"compounds":"ATP(in) + CoA(in) + H(+)(out) + hexadecanoate(out) <=> AMP(in) + diphosphate(in) + H(+)(in) + hexadecanoyl-CoA(in)"}
{"X":53137,"RHEA_ID":55038,"compounds":"an N,N,N-trimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine => an N,N-dimethylornithine lipid + S-adenosyl-L-methionine"}
{"X":53138,"RHEA_ID":51721,"compounds":"ATP(in) + CoA(in) + H(+)(out) + octadecanoate(out) => AMP(in) + diphosphate(in) + H(+)(in) + octadecanoyl-CoA(in)"}
{"X":53139,"RHEA_ID":58382,"compounds":"H(+) + NADPH + nonanal => NADP(+) + nonan-1-ol"}
{"X":53140,"RHEA_ID":51723,"compounds":"ATP(in) + CoA(in) + H(+)(out) + octadecanoate(out) <=> AMP(in) + diphosphate(in) + H(+)(in) + octadecanoyl-CoA(in)"}
{"X":53141,"RHEA_ID":51724,"compounds":"H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate = adenosine 5'-tetraphosphate + ADP + 2 H(+)"}
{"X":53142,"RHEA_ID":56181,"DIRECTION":"LR","MASTER_ID":56180,"metacyc":"RXN-18507","compounds":"8-carboxy-8-demethylriboflavin 5'-phosphate + 2 A + H2O + L-glutamate => 2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 2 AH2 + CO2"}
{"X":53143,"RHEA_ID":62087,"compounds":"ADP + D-glucosamine <=> AMP + D-glucosamine 6-phosphate + H(+)"}
{"X":53144,"RHEA_ID":51727,"compounds":"H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate <=> adenosine 5'-tetraphosphate + ADP + 2 H(+)"}
{"X":53145,"RHEA_ID":51728,"compounds":"dihydroxyacetone phosphate + H2O = dihydroxyacetone + phosphate"}
{"X":53146,"RHEA_ID":51729,"DIRECTION":"LR","MASTER_ID":51728,"ecocyc":"RXN0-7249","metacyc":"RXN0-7249","compounds":"dihydroxyacetone phosphate + H2O => dihydroxyacetone + phosphate"}
{"X":53147,"RHEA_ID":62090,"compounds":"2-amino-2-deoxy-6-phospho-D-glucono-1,5-lactone + 2 H(+) + NADPH => D-glucosamine 6-phosphate + NADP(+)"}
{"X":53148,"RHEA_ID":62092,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-diphosphate + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + phosphate"}
{"X":53149,"RHEA_ID":51732,"compounds":"glandicoline B + S-adenosyl-L-methionine = H(+) + meleagrin + S-adenosyl-L-homocysteine"}
{"X":53150,"RHEA_ID":51733,"DIRECTION":"LR","MASTER_ID":51732,"metacyc":"RXN-16145","compounds":"glandicoline B + S-adenosyl-L-methionine => H(+) + meleagrin + S-adenosyl-L-homocysteine"}
{"X":53151,"RHEA_ID":62095,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-diphosphate + H2O <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + phosphate"}
{"X":53152,"RHEA_ID":62096,"compounds":"2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 2-(9Z-octadecenoyl)-glycerol + phosphate"}
{"X":53153,"RHEA_ID":51736,"compounds":"L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":53154,"RHEA_ID":51737,"compounds":"L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":53155,"RHEA_ID":55056,"DIRECTION":"UN","MASTER_ID":55056,"ec":"1.14.14.49","compounds":"a 12-hydroxyjasmonyl-L-alpha-amino acid + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":53156,"RHEA_ID":52854,"compounds":"6-carboxyhexanoyl-[ACP] + a fatty aldehyde + 3 H(+) + 3 H2O + 2 oxidized [flavodoxin] => a C2-C8-saturated long-chain fatty acyl-[ACP] + 3 O2 + 2 reduced [flavodoxin]"}
{"X":53157,"RHEA_ID":51741,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A => a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate)"}
{"X":53158,"RHEA_ID":62103,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate"}
{"X":53159,"RHEA_ID":62104,"compounds":"(9Z)-octadecenoyl-CoA + sn-glycero-3-phosphoethanolamine = (9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":53160,"RHEA_ID":51744,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A = a 1,2-diacyl-sn-glycerol + lipid A 1-(2-aminoethyl diphosphate)"}
{"X":53161,"RHEA_ID":51745,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A => a 1,2-diacyl-sn-glycerol + lipid A 1-(2-aminoethyl diphosphate)"}
{"X":53162,"RHEA_ID":62107,"compounds":"(9Z)-octadecenoyl-CoA + sn-glycero-3-phosphoethanolamine <=> (9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":53163,"RHEA_ID":55065,"compounds":"4-methylpentanoyl-CoA + H2O => 4-methylpentanoate + CoA + H(+)"}
{"X":53164,"RHEA_ID":52863,"compounds":"a short-chain fatty acid + ATP + CoA <=> a short chain fatty acyl-CoA + AMP + diphosphate"}
{"X":53165,"RHEA_ID":51749,"compounds":"4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A => 4-amino-4-deoxy-beta-L-arabinopyranosyl-lipid A + di-trans,octa-cis-undecaprenyl phosphate"}
{"X":53166,"RHEA_ID":62111,"compounds":"an acyl-CoA + sn-glycero-3-phosphoethanolamine <=> a monoacyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":53167,"RHEA_ID":55069,"compounds":"a 12-oxojasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase] => a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53168,"RHEA_ID":62113,"compounds":"(3S)-3-hydroxy-D-aspartate => H2O + iminosuccinate"}
{"X":53169,"RHEA_ID":51753,"DIRECTION":"LR","MASTER_ID":51752,"metacyc":"RXN-18443","compounds":"a 2-acylphloroglucinol + dimethylallyl diphosphate => a 2-acyl-4-prenylphloroglucinol + diphosphate"}
{"X":53170,"RHEA_ID":62115,"compounds":"(3S)-3-hydroxy-D-aspartate <=> H2O + iminosuccinate"}
{"X":53171,"RHEA_ID":62116,"compounds":"H2O + iminosuccinate = NH4(+) + oxaloacetate"}
{"X":53172,"RHEA_ID":52871,"compounds":"17alpha-estradiol + UDP-alpha-D-glucuronate <=> 17alpha-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":53173,"RHEA_ID":62118,"compounds":"NH4(+) + oxaloacetate => H2O + iminosuccinate"}
{"X":53174,"RHEA_ID":62119,"compounds":"H2O + iminosuccinate <=> NH4(+) + oxaloacetate"}
{"X":53175,"RHEA_ID":62124,"compounds":"a 2'-deoxyribonucleoside 5'-phosphate + GTP = a 2'-deoxyribonucleoside 5'-diphosphate + GDP"}
{"X":53176,"RHEA_ID":51760,"DIRECTION":"UN","MASTER_ID":51760,"ec":"2.5.1.137","compounds":"a 2-acyl-4,6-diprenylphloroglucinol + dimethylallyl diphosphate = a 2-acyl-4,6,6-triprenylphloroglucinol + diphosphate"}
{"X":53177,"RHEA_ID":55079,"compounds":"4-methylsulfanyl-2-oxobutanoate + H(+) <=> 3-methylsulfanylpropanal + CO2"}
{"X":53178,"RHEA_ID":59573,"DIRECTION":"LR","MASTER_ID":59572,"metacyc":"RXN-19944","compounds":"H2O + L-homocarnosine => 4-aminobutanoate + L-histidine"}
{"X":53179,"RHEA_ID":62128,"compounds":"a 2'-deoxyribonucleoside 5'-phosphate + dGTP = a 2'-deoxyribonucleoside 5'-diphosphate + dGDP"}
{"X":53180,"RHEA_ID":51764,"DIRECTION":"UN","MASTER_ID":51764,"ec":"2.5.1.136","compounds":"dimethylallyl diphosphate + phlorisovalerophenone = 4-prenylphlorisovalerophenone + diphosphate"}
{"X":53181,"RHEA_ID":58425,"compounds":"(E)-hex-2-en-1-ol + NADP(+) => (E)-2-hexenal + H(+) + NADPH"}
{"X":53182,"RHEA_ID":62131,"compounds":"a 2'-deoxyribonucleoside 5'-phosphate + dGTP <=> a 2'-deoxyribonucleoside 5'-diphosphate + dGDP"}
{"X":53183,"RHEA_ID":51767,"compounds":"dimethylallyl diphosphate + phlorisovalerophenone <=> 4-prenylphlorisovalerophenone + diphosphate"}
{"X":53184,"RHEA_ID":62133,"compounds":"a 2'-deoxyribonucleoside 5'-phosphate + dTTP => a 2'-deoxyribonucleoside 5'-diphosphate + dTDP"}
{"X":53185,"RHEA_ID":51769,"DIRECTION":"LR","MASTER_ID":51768,"metacyc":"RXN-18442","compounds":"2-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one + dimethylallyl diphosphate => 4-prenylphlormethylbutanophenone + diphosphate"}
{"X":53186,"RHEA_ID":62135,"compounds":"a 2'-deoxyribonucleoside 5'-phosphate + dTTP <=> a 2'-deoxyribonucleoside 5'-diphosphate + dTDP"}
{"X":53187,"RHEA_ID":51771,"compounds":"2-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one + dimethylallyl diphosphate <=> 4-prenylphlormethylbutanophenone + diphosphate"}
{"X":53188,"RHEA_ID":62137,"compounds":"dGMP + GTP => dGDP + GDP"}
{"X":53189,"RHEA_ID":62138,"compounds":"dGDP + GDP => dGMP + GTP"}
{"X":53190,"RHEA_ID":62139,"compounds":"dGMP + GTP <=> dGDP + GDP"}
{"X":53191,"RHEA_ID":51775,"compounds":"2-methyl-1-(2,4,6-trihydroxyphenyl)propan-1-one + dimethylallyl diphosphate <=> 4-prenylphlorisobutanophenone + diphosphate"}
{"X":53192,"RHEA_ID":51776,"DIRECTION":"UN","MASTER_ID":51776,"ec":"2.5.1.137","compounds":"4-prenylphlorisobutanophenone + dimethylallyl diphosphate = deoxycohumulone + diphosphate"}
{"X":53193,"RHEA_ID":51777,"DIRECTION":"LR","MASTER_ID":51776,"metacyc":"RXN-7813","compounds":"4-prenylphlorisobutanophenone + dimethylallyl diphosphate => deoxycohumulone + diphosphate"}
{"X":53194,"RHEA_ID":59588,"DIRECTION":"UN","MASTER_ID":59588,"ec":"6.3.2.11","compounds":"ATP + beta-alanine + L-ornithine = ADP + beta-alanyl-L-ornithine + H(+) + phosphate"}
{"X":53195,"RHEA_ID":51779,"compounds":"4-prenylphlorisobutanophenone + dimethylallyl diphosphate <=> deoxycohumulone + diphosphate"}
{"X":53196,"RHEA_ID":62145,"compounds":"dGMP + dGTP => 2 dGDP"}
{"X":53197,"RHEA_ID":55099,"compounds":"(3S)-hydroxypentanoyl-CoA + H2O <=> (3S)-hydroxypentanoate + CoA + H(+)"}
{"X":53198,"RHEA_ID":62146,"compounds":"2 dGDP => dGMP + dGTP"}
{"X":53199,"RHEA_ID":51783,"compounds":"4-prenylphlormethylbutanophenone + dimethylallyl diphosphate <=> deoxyadlupulone + diphosphate"}
{"X":53200,"RHEA_ID":62149,"compounds":"dGTP + dTMP => dGDP + dTDP"}
{"X":53201,"RHEA_ID":55103,"compounds":"3-oxopentanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxypentanoyl-[ACP] + NADP(+)"}
{"X":53202,"RHEA_ID":62150,"compounds":"dGDP + dTDP => dGTP + dTMP"}
{"X":53203,"RHEA_ID":51787,"compounds":"4-prenylphlorisovalerophenone + dimethylallyl diphosphate <=> deoxyhumulone + diphosphate"}
{"X":53204,"RHEA_ID":62153,"compounds":"dGMP + dTTP => dGDP + dTDP"}
{"X":53205,"RHEA_ID":55107,"compounds":"3-oxoheptanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxyheptanoyl-[ACP] + NADP(+)"}
{"X":53206,"RHEA_ID":51790,"compounds":"2-hydroxybenzoyl-CoA + AMP + H(+) => 2-hydroxybenzoyl-5'-AMP + CoA"}
{"X":53207,"RHEA_ID":55109,"compounds":"3-oxononanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxynonanoyl-[ACP] + NADP(+)"}
{"X":53208,"RHEA_ID":62161,"compounds":"H2O + N-(9Z-octadecenoyl)-ethanolamine phosphate => N-(9Z-octadecenoyl) ethanolamine + phosphate"}
{"X":53209,"RHEA_ID":51793,"compounds":"H(+) + NADH + O2 + salicylate => 2,3-dihydroxybenzoate + H2O + NAD(+)"}
{"X":53210,"RHEA_ID":62163,"compounds":"H2O + N-(9Z-octadecenoyl)-ethanolamine phosphate <=> N-(9Z-octadecenoyl) ethanolamine + phosphate"}
{"X":53211,"RHEA_ID":62164,"compounds":"beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine + H2O = D-glucosamine + N-acetyl-D-glucosamine"}
{"X":53212,"RHEA_ID":51796,"DIRECTION":"UN","MASTER_ID":51796,"ec":"2.5.1.137","compounds":"deoxycohumulone + dimethylallyl diphosphate = colupulone + diphosphate + H(+)"}
{"X":53213,"RHEA_ID":55115,"compounds":"3-oxo-4-methylpentanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxy-4-methylpentanoyl-[ACP] + NADP(+)"}
{"X":53214,"RHEA_ID":62167,"compounds":"beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine + H2O <=> D-glucosamine + N-acetyl-D-glucosamine"}
{"X":53215,"RHEA_ID":62168,"compounds":"H2O + N,N'-diacetylchitobiose = acetate + beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine"}
{"X":53216,"RHEA_ID":62169,"DIRECTION":"LR","MASTER_ID":62168,"ecocyc":"RXN-12543","metacyc":"RXN-12543","compounds":"H2O + N,N'-diacetylchitobiose => acetate + beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine"}
{"X":53217,"RHEA_ID":51801,"DIRECTION":"LR","MASTER_ID":51800,"metacyc":"RXN-18450","compounds":"deoxyadlupulone + dimethylallyl diphosphate => adlupulone + diphosphate + H(+)"}
{"X":53218,"RHEA_ID":62171,"compounds":"H2O + N,N'-diacetylchitobiose <=> acetate + beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine"}
{"X":53219,"RHEA_ID":55121,"compounds":"3-oxo-4-methylhexanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxy-4-methylhexanoyl-[ACP] + NADP(+)"}
{"X":53220,"RHEA_ID":62173,"compounds":"an N-acylethanolamine phosphate + H2O => an N-acylethanolamine + phosphate"}
{"X":53221,"RHEA_ID":51805,"DIRECTION":"LR","MASTER_ID":51804,"metacyc":"RXN-18441","compounds":"deoxyhumulone + dimethylallyl diphosphate => diphosphate + H(+) + lupulone"}
{"X":53222,"RHEA_ID":62175,"compounds":"an N-acylethanolamine phosphate + H2O <=> an N-acylethanolamine + phosphate"}
{"X":53223,"RHEA_ID":55125,"compounds":"(2E)-5-methylhexenoyl-[ACP] + H(+) + NADH => 5-methylhexanoyl-[ACP] + NAD(+)"}
{"X":53224,"RHEA_ID":62177,"compounds":"GDP-alpha-D-glucose + H2O => alpha-D-glucose 1-phosphate + GMP + 2 H(+)"}
{"X":53225,"RHEA_ID":55127,"compounds":"(2E)-5-methylhexenoyl-[ACP] + H(+) + NADH <=> 5-methylhexanoyl-[ACP] + NAD(+)"}
{"X":53226,"RHEA_ID":62178,"compounds":"alpha-D-glucose 1-phosphate + GMP + 2 H(+) => GDP-alpha-D-glucose + H2O"}
{"X":53227,"RHEA_ID":55129,"compounds":"(3R)-hydroxy-5-methylhexanoyl-[ACP] => (2E)-5-methylhexenoyl-[ACP] + H2O"}
{"X":53228,"RHEA_ID":51812,"compounds":"ATP(in) + CoA(in) + H(+)(out) + tetradecanoate(out) = AMP(in) + diphosphate(in) + H(+)(in) + tetradecanoyl-CoA(in)"}
{"X":53229,"RHEA_ID":51813,"compounds":"ATP(in) + CoA(in) + H(+)(out) + tetradecanoate(out) => AMP(in) + diphosphate(in) + H(+)(in) + tetradecanoyl-CoA(in)"}
{"X":53230,"RHEA_ID":62182,"compounds":"diphosphate + viteagnusin D => H2O + peregrinol diphosphate"}
{"X":53231,"RHEA_ID":55133,"DIRECTION":"LR","MASTER_ID":55132,"metacyc":"RXN-18014","compounds":"ATP + D-alanine + holo-[D-alanyl-carrier protein] => AMP + D-alanyl-[D-alanyl-carrier protein] + diphosphate"}
{"X":53232,"RHEA_ID":51816,"compounds":"ATP(in) + CoA(in) + dodecanoate(out) + H(+)(out) = AMP(in) + diphosphate(in) + dodecanoyl-CoA(in) + H(+)(in)"}
{"X":53233,"RHEA_ID":51817,"compounds":"ATP(in) + CoA(in) + dodecanoate(out) + H(+)(out) => AMP(in) + diphosphate(in) + dodecanoyl-CoA(in) + H(+)(in)"}
{"X":53234,"RHEA_ID":62186,"compounds":"diphosphate + labd-13(16),14-diene-9-ol => peregrinol diphosphate"}
{"X":53235,"RHEA_ID":55137,"DIRECTION":"LR","MASTER_ID":55136,"metacyc":"RXN-18011","compounds":"ATP + D-alanine + H(+) => D-alanyl-5'-AMP + diphosphate"}
{"X":53236,"RHEA_ID":62189,"compounds":"9alpha-copalyl diphosphate => diphosphate + syn-isopimara-7,15-diene"}
{"X":53237,"RHEA_ID":51821,"compounds":"ATP(in) + CoA(in) + decanoate(out) + H(+)(out) => AMP(in) + decanoyl-CoA(in) + diphosphate(in) + H(+)(in)"}
{"X":53238,"RHEA_ID":62191,"compounds":"9alpha-copalyl diphosphate <=> diphosphate + syn-isopimara-7,15-diene"}
{"X":53239,"RHEA_ID":55141,"DIRECTION":"LR","MASTER_ID":55140,"metacyc":"RXN-18012","compounds":"D-alanyl-5'-AMP + holo-[D-alanyl-carrier protein] => AMP + D-alanyl-[D-alanyl-carrier protein] + H(+)"}
{"X":53240,"RHEA_ID":51824,"compounds":"ATP(in) + CoA(in) + H(+)(out) + octanoate(out) = AMP(in) + diphosphate(in) + H(+)(in) + octanoyl-CoA(in)"}
{"X":53241,"RHEA_ID":51825,"compounds":"ATP(in) + CoA(in) + H(+)(out) + octanoate(out) => AMP(in) + diphosphate(in) + H(+)(in) + octanoyl-CoA(in)"}
{"X":53242,"RHEA_ID":62195,"compounds":"O2 + peregrinol + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + labd-13Z-ene-9,15,16-triol + oxidized [NADPH--hemoprotein reductase]"}
{"X":53243,"RHEA_ID":62196,"compounds":"2 [Fe(III)cytochrome c] + propan-2-ol = 2 [Fe(II)cytochrome c] + acetone + 2 H(+)"}
{"X":53244,"RHEA_ID":62197,"compounds":"2 [Fe(III)cytochrome c] + propan-2-ol => 2 [Fe(II)cytochrome c] + acetone + 2 H(+)"}
{"X":53245,"RHEA_ID":51829,"compounds":"ATP(in) + CoA(in) + docosanoate(out) + H(+)(out) => AMP(in) + diphosphate(in) + docosanoyl-CoA(in) + H(+)(in)"}
{"X":53246,"RHEA_ID":62199,"compounds":"2 [Fe(III)cytochrome c] + propan-2-ol <=> 2 [Fe(II)cytochrome c] + acetone + 2 H(+)"}
{"X":53247,"RHEA_ID":51831,"compounds":"ATP(in) + CoA(in) + docosanoate(out) + H(+)(out) <=> AMP(in) + diphosphate(in) + docosanoyl-CoA(in) + H(+)(in)"}
{"X":53248,"RHEA_ID":62201,"compounds":"2 [Fe(III)cytochrome c] + ethanol => 2 [Fe(II)cytochrome c] + acetaldehyde + 2 H(+)"}
{"X":53249,"RHEA_ID":51833,"compounds":"ATP(in) + CoA(in) + H(+)(out) + tetracosanoate(out) => AMP(in) + diphosphate(in) + H(+)(in) + tetracosanoyl-CoA(in)"}
{"X":53250,"RHEA_ID":51834,"compounds":"AMP(in) + diphosphate(in) + H(+)(in) + tetracosanoyl-CoA(in) => ATP(in) + CoA(in) + H(+)(out) + tetracosanoate(out)"}
{"X":53251,"RHEA_ID":62204,"compounds":"1-propanol + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H(+) + propanal"}
{"X":53252,"RHEA_ID":62205,"compounds":"1-propanol + 2 [Fe(III)cytochrome c] => 2 [Fe(II)cytochrome c] + 2 H(+) + propanal"}
{"X":53253,"RHEA_ID":51837,"compounds":"(9Z)-tetradecenoate(out) + ATP(in) + CoA(in) + H(+)(out) => (9Z)-tetradecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)"}
{"X":53254,"RHEA_ID":51838,"compounds":"(9Z)-tetradecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in) => (9Z)-tetradecenoate(out) + ATP(in) + CoA(in) + H(+)(out)"}
{"X":53255,"RHEA_ID":62208,"compounds":"3-methylphenol + O2 + reduced [NADPH--hemoprotein reductase] = 3-hydroxybenzyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53256,"RHEA_ID":55158,"compounds":"a quinol + S-sulfanylglutathione => a quinone + glutathione + H(+) + hydrogen sulfide"}
{"X":53257,"RHEA_ID":58501,"compounds":"betaine + H(+) + NADH + O2 => glyoxylate + H2O + NAD(+) + trimethylamine"}
{"X":53258,"RHEA_ID":62211,"compounds":"3-methylphenol + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-hydroxybenzyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53259,"RHEA_ID":62212,"compounds":"3-hydroxybenzyl alcohol + O2 + reduced [NADPH--hemoprotein reductase] = gentisyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53260,"RHEA_ID":62213,"DIRECTION":"LR","MASTER_ID":62212,"metacyc":"RXN-15473","compounds":"3-hydroxybenzyl alcohol + O2 + reduced [NADPH--hemoprotein reductase] => gentisyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53261,"RHEA_ID":51849,"compounds":"8-methylmenaquinone-6 + succinate => 8-methylmenaquinol-6 + fumarate"}
{"X":53262,"RHEA_ID":55164,"compounds":"a jasmonyl-L-isoleucinate + H(+) + NADPH + O2 = H2O + L-isoleucine-12-hydroxyjasmonate + NADP(+)"}
{"X":53263,"RHEA_ID":55165,"DIRECTION":"LR","MASTER_ID":55164,"metacyc":"RXN-18489","compounds":"a jasmonyl-L-isoleucinate + H(+) + NADPH + O2 => H2O + L-isoleucine-12-hydroxyjasmonate + NADP(+)"}
{"X":53264,"RHEA_ID":62217,"DIRECTION":"LR","MASTER_ID":62216,"metacyc":"RXN-15482","compounds":"isoepoxydon + NADP(+) => H(+) + NADPH + phyllostine"}
{"X":53265,"RHEA_ID":51853,"compounds":"(9Z,12Z)-octadecadienoate(out) + ATP(in) + CoA(in) + H(+)(out) => (9Z,12Z)-octadecadienoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)"}
{"X":53266,"RHEA_ID":62219,"compounds":"isoepoxydon + NADP(+) <=> H(+) + NADPH + phyllostine"}
{"X":53267,"RHEA_ID":55169,"DIRECTION":"LR","MASTER_ID":55168,"metacyc":"RXN-18455","compounds":"[TtuB sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) => [TtuB sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate"}
{"X":53268,"RHEA_ID":59674,"compounds":"D-maltotriono-1,5-lactone + H2O2 => D-maltotriose + O2"}
{"X":53269,"RHEA_ID":55171,"compounds":"[TtuB sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) <=> [TtuB sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate"}
{"X":53270,"RHEA_ID":62223,"compounds":"phyllostine <=> neopatulin"}
{"X":53271,"RHEA_ID":55173,"compounds":"2-oxoglutarate + hexanoyl-CoA + O2 => 2-hydroxyhexanoyl-CoA + CO2 + succinate"}
{"X":53272,"RHEA_ID":62225,"DIRECTION":"LR","MASTER_ID":62224,"metacyc":"RXN-15484","compounds":"H(+) + NADPH + neopatulin => (E)-ascladiol + NADP(+)"}
{"X":53273,"RHEA_ID":51861,"DIRECTION":"LR","MASTER_ID":51860,"metacyc":"RXN-18495","compounds":"(2E)-geranyl diphosphate + umbelliferone => 8-geranylumbelliferone + diphosphate"}
{"X":53274,"RHEA_ID":62227,"compounds":"H(+) + NADPH + neopatulin <=> (E)-ascladiol + NADP(+)"}
{"X":53275,"RHEA_ID":55177,"compounds":"2-oxoglutarate + butanoyl-CoA + O2 => 2-hydroxybutanoyl-CoA + CO2 + succinate"}
{"X":53276,"RHEA_ID":62229,"compounds":"(E)-ascladiol + A => AH2 + patulin"}
{"X":53277,"RHEA_ID":51865,"DIRECTION":"LR","MASTER_ID":51864,"metacyc":"RXN-18496","compounds":"(2E)-geranyl diphosphate + esculetin => 8-geranylesculetin + diphosphate"}
{"X":53278,"RHEA_ID":62231,"compounds":"(E)-ascladiol + A <=> AH2 + patulin"}
{"X":53279,"RHEA_ID":56317,"DIRECTION":"LR","MASTER_ID":56316,"metacyc":"RXN-13870","compounds":"3-amino-4-hydroxybenzoate + acetyl-CoA => 3-acetylamino-4-hydroxybenzoate + CoA"}
{"X":53280,"RHEA_ID":62233,"DIRECTION":"LR","MASTER_ID":62232,"metacyc":"RXN-19239","compounds":"a thymidine(6-4)thymidine in DNA => a thymidine dimer in DNA"}
{"X":53281,"RHEA_ID":51869,"DIRECTION":"LR","MASTER_ID":51868,"metacyc":"RXN-8382","compounds":"dimethylallyl diphosphate + umbelliferone => demethylsuberosin + diphosphate"}
{"X":53282,"RHEA_ID":62235,"compounds":"a thymidine(6-4)thymidine in DNA <=> a thymidine dimer in DNA"}
{"X":53283,"RHEA_ID":56321,"compounds":"a 5-hydroxy anthocyanidin + UDP-alpha-D-glucose => an anthocyanin 5-O-beta-D-glucoside + H(+) + UDP"}
{"X":53284,"RHEA_ID":51872,"DIRECTION":"UN","MASTER_ID":51872,"ec":"2.5.1.139","compounds":"dimethylallyl diphosphate + umbelliferone = diphosphate + osthenol"}
{"X":53285,"RHEA_ID":51873,"DIRECTION":"LR","MASTER_ID":51872,"metacyc":"RXN-18497","compounds":"dimethylallyl diphosphate + umbelliferone => diphosphate + osthenol"}
{"X":53286,"RHEA_ID":62239,"compounds":"a cytidine(6-4)cytidine in DNA <=> a cytidine dimer in DNA + H(+)"}
{"X":53287,"RHEA_ID":62240,"DIRECTION":"UN","MASTER_ID":62240,"ec":"4.1.99.13","compounds":"a thymidine(6-4)cytidine in DNA = a thymine-cytidine dinucleotide in DNA"}
{"X":53288,"RHEA_ID":51876,"DIRECTION":"UN","MASTER_ID":51876,"ec":"2.5.1.136","compounds":"2',4,4',6'-tetrahydroxychalcone + dimethylallyl diphosphate = desmethylxanthohumol + diphosphate"}
{"X":53289,"RHEA_ID":51877,"DIRECTION":"LR","MASTER_ID":51876,"metacyc":"RXN-7820","compounds":"2',4,4',6'-tetrahydroxychalcone + dimethylallyl diphosphate => desmethylxanthohumol + diphosphate"}
{"X":53290,"RHEA_ID":62243,"compounds":"a thymidine(6-4)cytidine in DNA <=> a thymine-cytidine dinucleotide in DNA"}
{"X":53291,"RHEA_ID":55193,"compounds":"2-oxoglutarate + 3-methyldodecanoyl-CoA + O2 => 2-hydroxy-3-methyldodecanoyl-CoA + CO2 + succinate"}
{"X":53292,"RHEA_ID":62245,"compounds":"a cytidine(6-4)thymidine in DNA => a cytidine-thymine dinucleotide in DNA"}
{"X":53293,"RHEA_ID":51881,"DIRECTION":"LR","MASTER_ID":51880,"metacyc":"RXN-9888","compounds":"3,4,6-trichlorocatechol + O2 => (2Z,4E)-2,3,5-trichloromuconate + H(+)"}
{"X":53294,"RHEA_ID":62247,"compounds":"a cytidine(6-4)thymidine in DNA <=> a cytidine-thymine dinucleotide in DNA"}
{"X":53295,"RHEA_ID":55197,"compounds":"2-hydroxyoctadecanoyl-CoA => formyl-CoA + heptadecanal"}
{"X":53296,"RHEA_ID":51884,"DIRECTION":"UN","MASTER_ID":51884,"ec":"5.1.1.22","compounds":"L-proline betaine = D-proline betaine"}
{"X":53297,"RHEA_ID":51885,"compounds":"L-proline betaine => D-proline betaine"}
{"X":53298,"RHEA_ID":62251,"compounds":"chloroacetaldehyde + H2O + NADP(+) <=> chloroacetate + 2 H(+) + NADPH"}
{"X":53299,"RHEA_ID":55201,"DIRECTION":"LR","MASTER_ID":55200,"metacyc":"RXN-19229","compounds":"5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine => 2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H(+) + L-methionine"}
{"X":53300,"RHEA_ID":62253,"compounds":"2 hydrogencarbonate(out) + Zn(2+)(out) => 2 hydrogencarbonate(in) + Zn(2+)(in)"}
{"X":53301,"RHEA_ID":51889,"compounds":"2,3,5,6-tetrachlorohydroquinone + H(+) + NAD(+) => 2,3,5,6-tetrachloro-1,4-benzoquinone + NADH"}
{"X":53302,"RHEA_ID":62255,"compounds":"2 hydrogencarbonate(out) + Zn(2+)(out) <=> 2 hydrogencarbonate(in) + Zn(2+)(in)"}
{"X":53303,"RHEA_ID":55205,"DIRECTION":"LR","MASTER_ID":55204,"metacyc":"RXN-19230","compounds":"5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine => 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H(+) + L-methionine + NH4(+)"}
{"X":53304,"RHEA_ID":62257,"compounds":"Cd(2+)(out) + 2 hydrogencarbonate(out) => Cd(2+)(in) + 2 hydrogencarbonate(in)"}
{"X":53305,"RHEA_ID":51893,"compounds":"H2O + N-acetylcadaverine => acetate + cadaverine"}
{"X":53306,"RHEA_ID":62259,"compounds":"Cd(2+)(out) + 2 hydrogencarbonate(out) <=> Cd(2+)(in) + 2 hydrogencarbonate(in)"}
{"X":53307,"RHEA_ID":51895,"compounds":"H2O + N-acetylcadaverine <=> acetate + cadaverine"}
{"X":53308,"RHEA_ID":62261,"compounds":"2 hydrogencarbonate(out) + Mn(2+)(out) => 2 hydrogencarbonate(in) + Mn(2+)(in)"}
{"X":53309,"RHEA_ID":51897,"compounds":"H2O + N(1)-acetylspermine => acetate + spermine"}
{"X":53310,"RHEA_ID":62263,"compounds":"2 hydrogencarbonate(out) + Mn(2+)(out) <=> 2 hydrogencarbonate(in) + Mn(2+)(in)"}
{"X":53311,"RHEA_ID":51899,"compounds":"H2O + N(1)-acetylspermine <=> acetate + spermine"}
{"X":53312,"RHEA_ID":55214,"compounds":"formyl-CoA + pentadecanal => (2R)-hydroxyhexadecanoyl-CoA"}
{"X":53313,"RHEA_ID":51901,"compounds":"H2O + N(1)-acetylspermidine => acetate + spermidine"}
{"X":53314,"RHEA_ID":62267,"compounds":"hydrogencarbonate(out) + selenite(out) + Zn(2+)(out) <=> hydrogencarbonate(in) + selenite(in) + Zn(2+)(in)"}
{"X":53315,"RHEA_ID":51903,"compounds":"H2O + N(1)-acetylspermidine <=> acetate + spermidine"}
{"X":53316,"RHEA_ID":58560,"compounds":"15alpha-stemmadenine intermediate II + NADP(+) = 15alpha-stemmadenine intermediate I + NADPH"}
{"X":53317,"RHEA_ID":51905,"DIRECTION":"LR","MASTER_ID":51904,"ecocyc":"FORMYLTHFGLUSYNTH-RXN","metacyc":"FORMYLTHFGLUSYNTH-RXN","compounds":"10-formyltetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate => 10-formyltetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate"}
{"X":53318,"RHEA_ID":62271,"compounds":"(R)-2-hydroxy-3-methylbutyrate + NADP(+) <=> 3-methyl-2-oxobutanoate + H(+) + NADPH"}
{"X":53319,"RHEA_ID":58563,"compounds":"15alpha-stemmadenine intermediate II + NADP(+) <=> 15alpha-stemmadenine intermediate I + NADPH"}
{"X":53320,"RHEA_ID":58564,"compounds":"15alpha-stemmadenine + NADP(+) = 15alpha-stemmadenine intermediate II + 2 H(+) + NADPH"}
{"X":53321,"RHEA_ID":51909,"DIRECTION":"LR","MASTER_ID":51908,"metacyc":"RXN-14214","compounds":"dATP + H2O => dADP + H(+) + phosphate"}
{"X":53322,"RHEA_ID":56360,"compounds":"13-deoxycarminomycin + H(+) + NADPH + O2 = 13-dihydrocarminomycin + H2O + NADP(+)"}
{"X":53323,"RHEA_ID":58567,"compounds":"15alpha-stemmadenine + NADP(+) <=> 15alpha-stemmadenine intermediate II + 2 H(+) + NADPH"}
{"X":53324,"RHEA_ID":58568,"compounds":"15alpha-stemmadenine + acetyl-CoA = CoA + O-acetyl-15alpha-stemmadenine"}
{"X":53325,"RHEA_ID":51913,"DIRECTION":"LR","MASTER_ID":51912,"metacyc":"RXN0-2921","compounds":"(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate => (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate"}
{"X":53326,"RHEA_ID":51914,"compounds":"(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate => (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate"}
{"X":53327,"RHEA_ID":51915,"compounds":"(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate <=> (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate"}
{"X":53328,"RHEA_ID":62285,"compounds":"2 ATP + L-proline + L-tryptophan + NADPH => (8aS)-3-[(1H-indol-3-yl)methyl]-1H,2H,6H,7H,8H,8aH-pyrrolo[1,2-a]pyrazin-1-one + 2 AMP + 2 diphosphate + H(+) + H2O + NADP(+)"}
{"X":53329,"RHEA_ID":51917,"compounds":"(2S)-2-amino-3-butenoate + H2O => 2-oxobutanoate + NH4(+)"}
{"X":53330,"RHEA_ID":62287,"compounds":"2 ATP + L-proline + L-tryptophan + NADPH <=> (8aS)-3-[(1H-indol-3-yl)methyl]-1H,2H,6H,7H,8H,8aH-pyrrolo[1,2-a]pyrazin-1-one + 2 AMP + 2 diphosphate + H(+) + H2O + NADP(+)"}
{"X":53331,"RHEA_ID":53034,"compounds":"17beta-estradiol 2-O-(beta-D-glucuronate) + H(+) + UDP => 2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate"}
{"X":53332,"RHEA_ID":58576,"compounds":"dihydroprecondylocarpine acetate + NADP(+) = H(+) + NADPH + precondylocarpine acetate"}
{"X":53333,"RHEA_ID":51921,"compounds":"a quinone + AH2 => A + a quinol"}
{"X":53334,"RHEA_ID":62291,"compounds":"(8aS)-3-[(1H-indol-3-yl)methyl]-1H,2H,6H,7H,8H,8aH-pyrrolo[1,2-a]pyrazin-1-one + dimethylallyl diphosphate <=> (8aS)-3-{[2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl]methyl}-1H,2H,6H,7H,8H,8aH-pyrrolo[1,2-a]pyrazin-1-one + diphosphate"}
{"X":53335,"RHEA_ID":51923,"compounds":"a quinone + AH2 <=> A + a quinol"}
{"X":53336,"RHEA_ID":55238,"compounds":"(9Z)-octadecenoate + 1-octadecanoyl-2-hydroxy-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H(+) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H2O"}
{"X":53337,"RHEA_ID":51925,"DIRECTION":"LR","MASTER_ID":51924,"metacyc":"RXN-16868","compounds":"AH2 + menaquinone-9 => A + beta-dihydromenaquinone-9"}
{"X":53338,"RHEA_ID":62295,"compounds":"(8aS)-3-{[2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl]methyl}-1H,2H,6H,7H,8H,8aH-pyrrolo[1,2-a]pyrazin-1-one + A + H(+) <=> 1-hydroxy-3-{[2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl]methyl}-6H,7H,8H-5lambda5-pyrrolo[1,2-a]pyrazine + AH2"}
{"X":53339,"RHEA_ID":53042,"compounds":"17beta-estradiol 4-O-(beta-D-glucuronate) + H(+) + UDP => 4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate"}
{"X":53340,"RHEA_ID":59746,"compounds":"CoA + S-(9Z-octadecenoyl)-L-cysteinyl-[protein] => (9Z)-octadecenoyl-CoA + L-cysteinyl-[protein]"}
{"X":53341,"RHEA_ID":51929,"DIRECTION":"LR","MASTER_ID":51928,"metacyc":"RXN-18393","compounds":"H2O + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + NAD(+) => (S)-2,3-diaminopropanoate + 2-oxoglutarate + H(+) + NADH"}
{"X":53342,"RHEA_ID":62299,"compounds":"(+)-premalbrancheamide + 2 chloride + 2 FAD + 4 H(+) <=> (+)-malbrancheamide + 2 FADH2"}
{"X":53343,"RHEA_ID":62300,"compounds":"1-hydroxy-3-{[2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl]methyl}-6H,7H,8H-5lambda5-pyrrolo[1,2-a]pyrazine + H(+) + NADPH = 1-hydroxy-3-{[2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine + NADP(+)"}
{"X":53344,"RHEA_ID":56382,"compounds":"(4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 FAD + 4 H2O => (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 chloride + 2 FADH2 + 2 O2"}
{"X":53345,"RHEA_ID":51933,"compounds":"2 [Fe(III)-cytochrome c3] + hydrogen sulfide + sulfite => 2 [Fe(II)-cytochrome c3] + thiosulfate"}
{"X":53346,"RHEA_ID":62303,"compounds":"1-hydroxy-3-{[2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl]methyl}-6H,7H,8H-5lambda5-pyrrolo[1,2-a]pyrazine + H(+) + NADPH <=> 1-hydroxy-3-{[2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine + NADP(+)"}
{"X":53347,"RHEA_ID":58591,"compounds":"dihydroprecondylocarpine acetate + NADPH <=> (+)-vincadifformine + acetate + NADP(+)"}
{"X":53348,"RHEA_ID":62305,"compounds":"1-hydroxy-3-{[2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine => (+)-premalbrancheamide"}
{"X":53349,"RHEA_ID":51937,"DIRECTION":"LR","MASTER_ID":51936,"metacyc":"RXN-18402","compounds":"2-(glutathione-S-yl)-hydroquinone + glutathione => glutathione disulfide + hydroquinone"}
{"X":53350,"RHEA_ID":51938,"compounds":"glutathione disulfide + hydroquinone => 2-(glutathione-S-yl)-hydroquinone + glutathione"}
{"X":53351,"RHEA_ID":62308,"compounds":"(+)-premalbrancheamide + chloride + FAD + 2 H(+) = (+)-malbrancheamide B + FADH2"}
{"X":53352,"RHEA_ID":62309,"compounds":"(+)-premalbrancheamide + chloride + FAD + 2 H(+) => (+)-malbrancheamide B + FADH2"}
{"X":53353,"RHEA_ID":55255,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine <=> 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":53354,"RHEA_ID":51942,"compounds":"(1Z,2S)-2-methylbutanal oxime => (1E,2S)-2-methylbutanal oxime"}
{"X":53355,"RHEA_ID":58603,"compounds":"2 L-ascorbate + N-(9Z-octadecenoyl)glycine + O2 <=> H2O + 2 monodehydro-L-ascorbate radical + N-(9Z-octadecenoyl)-(2S)-hydroxyglycine"}
{"X":53356,"RHEA_ID":51944,"DIRECTION":"UN","MASTER_ID":51944,"ec":"2.1.1.343","compounds":"8-amino-8-demethylriboflavin + 2 S-adenosyl-L-methionine = 2 H(+) + roseoflavin + 2 S-adenosyl-L-homocysteine"}
{"X":53357,"RHEA_ID":62314,"compounds":"H(+) + salicylate 2-O-beta-D-glucoside + UDP => salicylate + UDP-alpha-D-glucose"}
{"X":53358,"RHEA_ID":55260,"compounds":"2 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":53359,"RHEA_ID":62316,"compounds":"salicylate + UDP-alpha-D-glucose = 1-O-salicyl-beta-D-glucose + UDP"}
{"X":53360,"RHEA_ID":51948,"compounds":"(2S)-2-methylbutanenitrile + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-2-methylbutanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53361,"RHEA_ID":62318,"compounds":"1-O-salicyl-beta-D-glucose + UDP => salicylate + UDP-alpha-D-glucose"}
{"X":53362,"RHEA_ID":62319,"compounds":"salicylate + UDP-alpha-D-glucose <=> 1-O-salicyl-beta-D-glucose + UDP"}
{"X":53363,"RHEA_ID":51952,"DIRECTION":"UN","MASTER_ID":51952,"ec":"1.14.14.41","compounds":"(E)-2-methylpropanal oxime + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-2-methylpropanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53364,"RHEA_ID":62322,"compounds":"(+)-isomalbrancheamide B + FADH2 => (+)-premalbrancheamide + chloride + FAD + 2 H(+)"}
{"X":53365,"RHEA_ID":55268,"DIRECTION":"UN","MASTER_ID":55268,"ec":"2.4.1.352","compounds":"(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate = (R)-glycerate + alpha-D-glucose 1-phosphate"}
{"X":53366,"RHEA_ID":51956,"compounds":"(E)-2-methylpropanal oxime = (Z)-2-methylpropanal oxime"}
{"X":53367,"RHEA_ID":55271,"DIRECTION":"BI","MASTER_ID":55268,"metacyc":"RXN-18999","compounds":"(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate <=> (R)-glycerate + alpha-D-glucose 1-phosphate"}
{"X":53368,"RHEA_ID":55272,"compounds":"11-cis-retinol + tetradecanoyl-CoA = 11-cis-retinyl tetradecanoate + CoA"}
{"X":53369,"RHEA_ID":62328,"compounds":"(+)-isomalbrancheamide B + chloride + FAD + 2 H(+) = (+)-malbrancheamide + FADH2"}
{"X":53370,"RHEA_ID":51960,"compounds":"(Z)-2-methylpropanal oxime = 2-methylpropanenitrile + H2O"}
{"X":53371,"RHEA_ID":51961,"DIRECTION":"LR","MASTER_ID":51960,"metacyc":"RXN-5081","compounds":"(Z)-2-methylpropanal oxime => 2-methylpropanenitrile + H2O"}
{"X":53372,"RHEA_ID":55276,"compounds":"9-cis-retinol + tetradecanoyl-CoA = 9-cis-retinyl tetradecanoate + CoA"}
{"X":53373,"RHEA_ID":62332,"compounds":"ADP + ATP = adenosine 3'-diphosphate,5'-diphosphate + AMP"}
{"X":53374,"RHEA_ID":51964,"compounds":"2-methylpropanenitrile + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-2-methylpropanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53375,"RHEA_ID":51965,"DIRECTION":"LR","MASTER_ID":51964,"metacyc":"RXN-5082","compounds":"2-methylpropanenitrile + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-2-methylpropanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53376,"RHEA_ID":62335,"compounds":"ADP + ATP <=> adenosine 3'-diphosphate,5'-diphosphate + AMP"}
{"X":53377,"RHEA_ID":51968,"compounds":"(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 = (5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate"}
{"X":53378,"RHEA_ID":51969,"DIRECTION":"LR","MASTER_ID":51968,"reactome":"R-HSA-9018863.1","compounds":"(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 => (5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate"}
{"X":53379,"RHEA_ID":55284,"compounds":"all-trans-retinol + tetradecanoyl-CoA = all-trans-retinyl tetradecanoate + CoA"}
{"X":53380,"RHEA_ID":53086,"compounds":"[(1->2)-beta-D-glucosyl](n+1) + H(+) + UDP => [(1->2)-beta-D-glucosyl](n) + UDP-alpha-D-glucose"}
{"X":53381,"RHEA_ID":62341,"compounds":"(+)-premalbrancheamide + bromide + FAD + 2 H(+) => (+)-malbrancheamide C + FADH2"}
{"X":53382,"RHEA_ID":51973,"DIRECTION":"LR","MASTER_ID":51972,"metacyc":"RXN-18175","compounds":"an L-polyhomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":53383,"RHEA_ID":55288,"compounds":"tetradecan-1-ol + tetradecanoyl-CoA = CoA + tetradecanyl tetradecanoate"}
{"X":53384,"RHEA_ID":51976,"compounds":"an L-N-hydroxypolyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = an L-N,N-dihydroxypolyhomomethionine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53385,"RHEA_ID":51977,"DIRECTION":"LR","MASTER_ID":51976,"metacyc":"RXN-18173","compounds":"an L-N-hydroxypolyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => an L-N,N-dihydroxypolyhomomethionine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53386,"RHEA_ID":62347,"compounds":"6-hydroxydeoxybrevianamide E + dimethylallyl diphosphate <=> diphosphate + notoamide S"}
{"X":53387,"RHEA_ID":62348,"compounds":"H(+) + NADPH + notoamide E + O2 = H2O + NADP(+) + notoamide C"}
{"X":53388,"RHEA_ID":51980,"compounds":"an L-N,N-dihydroxypolyhomomethionine + H(+) = an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + H2O"}
{"X":53389,"RHEA_ID":51981,"DIRECTION":"LR","MASTER_ID":51980,"metacyc":"RXN-18174","compounds":"an L-N,N-dihydroxypolyhomomethionine + H(+) => an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + H2O"}
{"X":53390,"RHEA_ID":55296,"compounds":"13-cis-retinol + hexadecanoyl-CoA = 13-cis-retinyl hexadecanoate + CoA"}
{"X":53391,"RHEA_ID":62352,"compounds":"H(+) + NADPH + notoamide E + O2 = H2O + NADP(+) + notoamide D"}
{"X":53392,"RHEA_ID":51984,"compounds":"all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53393,"RHEA_ID":51985,"compounds":"all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53394,"RHEA_ID":55300,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":53395,"RHEA_ID":62356,"DIRECTION":"UN","MASTER_ID":62356,"ec":"3.6.1.58","compounds":"8-oxo-GDP + H2O = 8-oxo-GMP + H(+) + phosphate"}
{"X":53396,"RHEA_ID":51988,"compounds":"(5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O = 18S-resolvin E1"}
{"X":53397,"RHEA_ID":51989,"compounds":"(5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O => 18S-resolvin E1"}
{"X":53398,"RHEA_ID":62359,"compounds":"8-oxo-GDP + H2O <=> 8-oxo-GMP + H(+) + phosphate"}
{"X":53399,"RHEA_ID":62360,"compounds":"FMNH2 + O2 + uracil = (Z)-3-ureidoacrylate + FMN-N(5)-oxide + 2 H(+)"}
{"X":53400,"RHEA_ID":51992,"DIRECTION":"UN","MASTER_ID":51992,"ec":"1.14.14.43","compounds":"an (E)-omega-(methylsulfanyl)-alkanal oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] = an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53401,"RHEA_ID":51993,"DIRECTION":"LR","MASTER_ID":51992,"metacyc":"RXN-18171","compounds":"an (E)-omega-(methylsulfanyl)-alkanal oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] => an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53402,"RHEA_ID":62363,"compounds":"FMNH2 + O2 + uracil <=> (Z)-3-ureidoacrylate + FMN-N(5)-oxide + 2 H(+)"}
{"X":53403,"RHEA_ID":58655,"compounds":"rifamycin SV ortho-naphthoquinone carboxamide <=> rifamycin SV para-naphthoquinone carboxamide"}
{"X":53404,"RHEA_ID":51996,"compounds":"an (E)-omega-(methylsulfanyl)-alkanal oxime + O2 + reduced [NADPH--hemoprotein reductase] = a 1-(methylsulfanyl)-4-aci-nitroalkane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53405,"RHEA_ID":51997,"DIRECTION":"LR","MASTER_ID":51996,"metacyc":"RXN-18169","compounds":"an (E)-omega-(methylsulfanyl)-alkanal oxime + O2 + reduced [NADPH--hemoprotein reductase] => a 1-(methylsulfanyl)-4-aci-nitroalkane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53406,"RHEA_ID":51998,"compounds":"a 1-(methylsulfanyl)-4-aci-nitroalkane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an (E)-omega-(methylsulfanyl)-alkanal oxime + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":53407,"RHEA_ID":58659,"compounds":"a 5'-(5'-phospho)-ribonucleoside-RNA + S-adenosyl-L-methionine <=> a 5'-(5'-phosphomethyl)-ribonucleoside-RNA + S-adenosyl-L-homocysteine"}
{"X":53408,"RHEA_ID":62369,"compounds":"Fe(2+)(out) + 2 hydrogencarbonate(out) => Fe(2+)(in) + 2 hydrogencarbonate(in)"}
{"X":53409,"RHEA_ID":52001,"DIRECTION":"LR","MASTER_ID":52000,"metacyc":"RXN-18170","compounds":"a 1-(methylsulfanyl)-4-aci-nitroalkane + glutathione => an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O"}
{"X":53410,"RHEA_ID":62371,"compounds":"Fe(2+)(out) + 2 hydrogencarbonate(out) <=> Fe(2+)(in) + 2 hydrogencarbonate(in)"}
{"X":53411,"RHEA_ID":52008,"compounds":"8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + ATP + CoA = 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate"}
{"X":53412,"RHEA_ID":52009,"compounds":"8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + ATP + CoA => 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate"}
{"X":53413,"RHEA_ID":52010,"compounds":"8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate => 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + ATP + CoA"}
{"X":53414,"RHEA_ID":62375,"compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + uridine(54) in tRNA <=> (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NADP(+)"}
{"X":53415,"RHEA_ID":52012,"compounds":"11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + ATP + CoA = 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate"}
{"X":53416,"RHEA_ID":52013,"compounds":"11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + ATP + CoA => 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate"}
{"X":53417,"RHEA_ID":62407,"compounds":"(R)-2-hydroxyhexadecanoate + O2 <=> CO2 + H2O + pentadecanoate"}
{"X":53418,"RHEA_ID":52015,"compounds":"11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + ATP + CoA <=> 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate"}
{"X":53419,"RHEA_ID":52016,"compounds":"14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + ATP + CoA = 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoyl-CoA + AMP + diphosphate"}
{"X":53420,"RHEA_ID":52017,"compounds":"14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + ATP + CoA => 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoyl-CoA + AMP + diphosphate"}
{"X":53421,"RHEA_ID":62423,"compounds":"a (R)-2-hydroxy fatty acid + O2 <=> a fatty acid + CO2 + H2O"}
{"X":53422,"RHEA_ID":58675,"DIRECTION":"BI","MASTER_ID":58672,"ecocyc":"RXN-14693","metacyc":"RXN-14693","compounds":"D-glucuronate <=> aldehydo-D-glucuronate"}
{"X":53423,"RHEA_ID":52020,"DIRECTION":"UN","MASTER_ID":52020,"metacyc":"RXN66-547","compounds":"(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2 = A + H2O + resolvin E2"}
{"X":53424,"RHEA_ID":52021,"compounds":"(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2 => A + H2O + resolvin E2"}
{"X":53425,"RHEA_ID":55335,"compounds":"a 3'-hydroxyflavone + S-adenosyl-L-methionine <=> a 3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine"}
{"X":53426,"RHEA_ID":62444,"DIRECTION":"UN","MASTER_ID":62444,"ec":"2.1.4.3","compounds":"L-canavanine + L-ornithine = H(+) + L-arginine + L-canaline"}
{"X":53427,"RHEA_ID":62445,"compounds":"L-canavanine + L-ornithine => H(+) + L-arginine + L-canaline"}
{"X":53428,"RHEA_ID":52025,"compounds":"(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2 => 18S-resolvin E2 + A + H2O"}
{"X":53429,"RHEA_ID":62447,"compounds":"L-canavanine + L-ornithine <=> H(+) + L-arginine + L-canaline"}
{"X":53430,"RHEA_ID":58683,"compounds":"A + FADH2 <=> AH2 + FAD + H(+)"}
{"X":53431,"RHEA_ID":52028,"DIRECTION":"UN","MASTER_ID":52028,"ec":"3.5.1.127","compounds":"a jasmonyl-L-amino acid + H2O = a jasmonate + an L-alpha-amino acid"}
{"X":53432,"RHEA_ID":52029,"DIRECTION":"LR","MASTER_ID":52028,"metacyc":"RXN-18493","compounds":"a jasmonyl-L-amino acid + H2O => a jasmonate + an L-alpha-amino acid"}
{"X":53433,"RHEA_ID":56476,"compounds":"(5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 = (4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O"}
{"X":53434,"RHEA_ID":62472,"compounds":"1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-nonadioyl-sn-glycero-3-phosphocholine"}
{"X":53435,"RHEA_ID":58688,"compounds":"NADH + O2 + rifamycin SV = H2O + NAD(+) + rifamycin SV para-naphthoquinone carboxamide"}
{"X":53436,"RHEA_ID":52033,"DIRECTION":"LR","MASTER_ID":52032,"metacyc":"RXN-18484","compounds":"H2O + L-isoleucine-(+)-7-isojasmonate => (+)-7-isojasmonate + L-isoleucine"}
{"X":53437,"RHEA_ID":52034,"compounds":"(+)-7-isojasmonate + L-isoleucine => H2O + L-isoleucine-(+)-7-isojasmonate"}
{"X":53438,"RHEA_ID":62480,"compounds":"1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O = 2-glutaroyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":53439,"RHEA_ID":58692,"compounds":"FADH2-C4alpha-hydroperoxide + H(+) + NADH + rifamycin SV = FADH2 + H2O + NAD(+) + rifamycin SV hemiaminal"}
{"X":53440,"RHEA_ID":52037,"DIRECTION":"LR","MASTER_ID":52036,"metacyc":"RXN-18481","compounds":"H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate => L-isoleucine + tuberonate"}
{"X":53441,"RHEA_ID":62483,"compounds":"1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O <=> 2-glutaroyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":53442,"RHEA_ID":62484,"compounds":"1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":53443,"RHEA_ID":62485,"compounds":"1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O => 2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":53444,"RHEA_ID":52041,"DIRECTION":"LR","MASTER_ID":52040,"metacyc":"RXN-15128","compounds":"L-cystine => 2-aminoprop-2-enoate + S-sulfanyl-L-cysteine"}
{"X":53445,"RHEA_ID":62487,"compounds":"1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":53446,"RHEA_ID":62488,"compounds":"1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":53447,"RHEA_ID":62489,"compounds":"1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O => 2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":53448,"RHEA_ID":52045,"DIRECTION":"LR","MASTER_ID":52044,"metacyc":"RXN-18997","compounds":"mogrol + UDP-alpha-D-glucose => H(+) + mogroside IE + UDP"}
{"X":53449,"RHEA_ID":62490,"compounds":"2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O"}
{"X":53450,"RHEA_ID":58703,"compounds":"FADH2-C4alpha-hydroperoxide + NADPH + rifampicin <=> FADH2 + H(+) + H2O + NADP(+) + rifampicin hemiaminal"}
{"X":53451,"RHEA_ID":56494,"compounds":"gypsogenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => hederagenin + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":53452,"RHEA_ID":52049,"compounds":"9-(9Z-octadecenoyloxy)-octadecanoate + H2O => (9Z)-octadecenoate + 9-hydroxy-octadecanoate + H(+)"}
{"X":53453,"RHEA_ID":62510,"compounds":"(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}
{"X":53454,"RHEA_ID":62512,"compounds":"2-oxoglutarate + melatonin + O2 = 2-hydroxymelatonin + CO2 + succinate"}
{"X":53455,"RHEA_ID":62513,"compounds":"2-oxoglutarate + melatonin + O2 => 2-hydroxymelatonin + CO2 + succinate"}
{"X":53456,"RHEA_ID":52053,"compounds":"9-hexadecanoyloxy-octadecanoate + H2O => 9-hydroxy-octadecanoate + H(+) + hexadecanoate"}
{"X":53457,"RHEA_ID":62515,"compounds":"2-oxoglutarate + melatonin + O2 <=> 2-hydroxymelatonin + CO2 + succinate"}
{"X":53458,"RHEA_ID":62516,"compounds":"beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-galactosamine = H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP"}
{"X":53459,"RHEA_ID":52056,"compounds":"12-hexadecanoyloxy-octadecanoate + H2O = 12-hydroxyoctadecanoate + H(+) + hexadecanoate"}
{"X":53460,"RHEA_ID":55370,"compounds":"(3R)-3-hydroxy-4-oxobutanoate + H2O + NADP(+) + trimethylamine => (R)-carnitine + H(+) + NADPH + O2"}
{"X":53461,"RHEA_ID":62518,"compounds":"H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP => beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-galactosamine"}
{"X":53462,"RHEA_ID":52059,"compounds":"12-hexadecanoyloxy-octadecanoate + H2O <=> 12-hydroxyoctadecanoate + H(+) + hexadecanoate"}
{"X":53463,"RHEA_ID":52060,"compounds":"12-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)-octadecenoate + 12-hydroxyoctadecanoate + H(+)"}
{"X":53464,"RHEA_ID":55378,"compounds":"2 a quinone + 2 H2O => 2 a quinol + O2"}
{"X":53465,"RHEA_ID":62523,"compounds":"a cytidine in rRNA + S-adenosyl-L-methionine <=> an N(4)-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":53466,"RHEA_ID":52063,"compounds":"12-(9Z-octadecenoyloxy)-octadecanoate + H2O <=> (9Z)-octadecenoate + 12-hydroxyoctadecanoate + H(+)"}
{"X":53467,"RHEA_ID":52064,"compounds":"13-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)-octadecenoate + 13-hydroxy-octadecanoate + H(+)"}
{"X":53468,"RHEA_ID":52065,"compounds":"13-(9Z-octadecenoyloxy)-octadecanoate + H2O => (9Z)-octadecenoate + 13-hydroxy-octadecanoate + H(+)"}
{"X":53469,"RHEA_ID":62527,"compounds":"cytidine(839) in 12S rRNA + S-adenosyl-L-methionine <=> H(+) + N(4)-methylcytidine(839) in 12S rRNA + S-adenosyl-L-homocysteine"}
{"X":53470,"RHEA_ID":62528,"compounds":"2 [Fe(II)cytochrome c] + digoxin + 3 H(+) = 2 [Fe(III)cytochrome c] + dihydrodigoxin"}
{"X":53471,"RHEA_ID":62529,"compounds":"2 [Fe(II)cytochrome c] + digoxin + 3 H(+) => 2 [Fe(III)cytochrome c] + dihydrodigoxin"}
{"X":53472,"RHEA_ID":52069,"compounds":"9-(9Z-hexadecenoyloxy)-octadecanoate + H2O => (9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H(+)"}
{"X":53473,"RHEA_ID":55387,"compounds":"(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 6 isopentenyl diphosphate <=> 6 diphosphate + tetra-trans,hexa-cis-undecaprenyl diphosphate"}
{"X":53474,"RHEA_ID":62532,"compounds":"2 [Fe(II)cytochrome c] + digitoxin + 3 H(+) = 2 [Fe(III)cytochrome c] + dihydrodigitoxin"}
{"X":53475,"RHEA_ID":62533,"compounds":"2 [Fe(II)cytochrome c] + digitoxin + 3 H(+) => 2 [Fe(III)cytochrome c] + dihydrodigitoxin"}
{"X":53476,"RHEA_ID":52073,"compounds":"12-(9Z-hexadecenoyloxy)-octadecanoate + H2O => (9Z)-hexadecenoate + 12-hydroxyoctadecanoate + H(+)"}
{"X":53477,"RHEA_ID":58730,"compounds":"H(+) + N(6)-methyladenosine in rRNA + S-adenosyl-L-homocysteine => adenosine in rRNA + S-adenosyl-L-methionine"}
{"X":53478,"RHEA_ID":52075,"compounds":"12-(9Z-hexadecenoyloxy)-octadecanoate + H2O <=> (9Z)-hexadecenoate + 12-hydroxyoctadecanoate + H(+)"}
{"X":53479,"RHEA_ID":52076,"compounds":"13-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 13-hydroxy-octadecanoate + H(+)"}
{"X":53480,"RHEA_ID":52077,"compounds":"13-(9Z-hexadecenoyloxy)-octadecanoate + H2O => (9Z)-hexadecenoate + 13-hydroxy-octadecanoate + H(+)"}
{"X":53481,"RHEA_ID":62539,"compounds":"2 [Fe(II)cytochrome c] + digoxigenin + 3 H(+) <=> 2 [Fe(III)cytochrome c] + dihydrodigoxigenin"}
{"X":53482,"RHEA_ID":52079,"compounds":"13-(9Z-hexadecenoyloxy)-octadecanoate + H2O <=> (9Z)-hexadecenoate + 13-hydroxy-octadecanoate + H(+)"}
{"X":53483,"RHEA_ID":52080,"compounds":"12-octadecanoyloxy-octadecanoate + H2O = 12-hydroxyoctadecanoate + H(+) + octadecanoate"}
{"X":53484,"RHEA_ID":55398,"compounds":"(3R)-3-hydroxy-4-oxobutanoate + H2O + NAD(+) + trimethylamine => (R)-carnitine + H(+) + NADH + O2"}
{"X":53485,"RHEA_ID":62542,"compounds":"2 [Fe(III)cytochrome c] + dihydroouabain => 2 [Fe(II)cytochrome c] + 3 H(+) + ouabain"}
{"X":53486,"RHEA_ID":52083,"compounds":"12-octadecanoyloxy-octadecanoate + H2O <=> 12-hydroxyoctadecanoate + H(+) + octadecanoate"}
{"X":53487,"RHEA_ID":52084,"compounds":"13-octadecanoyloxy-octadecanoate + H2O = 13-hydroxy-octadecanoate + H(+) + octadecanoate"}
{"X":53488,"RHEA_ID":52085,"compounds":"13-octadecanoyloxy-octadecanoate + H2O => 13-hydroxy-octadecanoate + H(+) + octadecanoate"}
{"X":53489,"RHEA_ID":58742,"compounds":"diphosphate + H(+) + psi-UMP => H2O + psi-UTP"}
{"X":53490,"RHEA_ID":52087,"compounds":"13-octadecanoyloxy-octadecanoate + H2O <=> 13-hydroxy-octadecanoate + H(+) + octadecanoate"}
{"X":53491,"RHEA_ID":52088,"compounds":"5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + ATP + CoA = 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate"}
{"X":53492,"RHEA_ID":52089,"compounds":"5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + ATP + CoA => 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate"}
{"X":53493,"RHEA_ID":62551,"compounds":"a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + UDP-alpha-D-galactose <=> beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + H(+) + UDP"}
{"X":53494,"RHEA_ID":62552,"compounds":"beta-D-glucosylceramide + UDP-alpha-D-galactose = beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H(+) + UDP"}
{"X":53495,"RHEA_ID":52092,"compounds":"5-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 5-hydroxy-octadecanoate + H(+)"}
{"X":53496,"RHEA_ID":52093,"compounds":"5-(9Z-hexadecenoyloxy)-octadecanoate + H2O => (9Z)-hexadecenoate + 5-hydroxy-octadecanoate + H(+)"}
{"X":53497,"RHEA_ID":52094,"compounds":"(9Z)-hexadecenoate + 5-hydroxy-octadecanoate + H(+) => 5-(9Z-hexadecenoyloxy)-octadecanoate + H2O"}
{"X":53498,"RHEA_ID":62556,"DIRECTION":"UN","MASTER_ID":62556,"ec":"4.1.1.83","compounds":"3,4-dihydroxyphenylacetate + H(+) = 4-methylcatechol + CO2"}
{"X":53499,"RHEA_ID":52096,"compounds":"9-octadecanoyloxy-octadecanoate + H2O = 9-hydroxy-octadecanoate + H(+) + octadecanoate"}
{"X":53500,"RHEA_ID":52097,"compounds":"9-octadecanoyloxy-octadecanoate + H2O => 9-hydroxy-octadecanoate + H(+) + octadecanoate"}
{"X":53501,"RHEA_ID":62559,"compounds":"3,4-dihydroxyphenylacetate + H(+) <=> 4-methylcatechol + CO2"}
{"X":53502,"RHEA_ID":62568,"compounds":"H2O + S-benzyl-L-cysteinylglycine = glycine + S-benzyl-L-cysteine"}
{"X":53503,"RHEA_ID":52100,"compounds":"5-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)-octadecenoate + 5-hydroxy-octadecanoate + H(+)"}
{"X":53504,"RHEA_ID":52101,"compounds":"5-(9Z-octadecenoyloxy)-octadecanoate + H2O => (9Z)-octadecenoate + 5-hydroxy-octadecanoate + H(+)"}
{"X":53505,"RHEA_ID":62571,"compounds":"H2O + S-benzyl-L-cysteinylglycine <=> glycine + S-benzyl-L-cysteine"}
{"X":53506,"RHEA_ID":55420,"compounds":"hexadecanoyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-hexadecanoyl-L-lysyl-[protein]"}
{"X":53507,"RHEA_ID":62573,"DIRECTION":"LR","MASTER_ID":62572,"metacyc":"RXN-19543","compounds":"H2O + S-(6-hydroxy-4-methylhexan-4-yl)-L-cysteinylglycine => glycine + S-(6-hydroxy-4-methylhexan-4-yl)-L-cysteine"}
{"X":53508,"RHEA_ID":62574,"compounds":"glycine + S-(6-hydroxy-4-methylhexan-4-yl)-L-cysteine => H2O + S-(6-hydroxy-4-methylhexan-4-yl)-L-cysteinylglycine"}
{"X":53509,"RHEA_ID":55423,"compounds":"hexadecanoyl-CoA + L-lysyl-[protein] <=> CoA + H(+) + N(6)-hexadecanoyl-L-lysyl-[protein]"}
{"X":53510,"RHEA_ID":55424,"DIRECTION":"UN","MASTER_ID":55424,"ec":"1.14.14.59","compounds":"(3S,6E)-nerolidol + O2 + reduced [NADPH--hemoprotein reductase] = (3E)-4,8-dimethylnona-1,3,7-triene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53511,"RHEA_ID":52108,"compounds":"5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate"}
{"X":53512,"RHEA_ID":62578,"compounds":"ADP + H(+) + L-cystine(in) + phosphate => ATP + H2O + L-cystine(out)"}
{"X":53513,"RHEA_ID":62579,"compounds":"ATP + H2O + L-cystine(out) <=> ADP + H(+) + L-cystine(in) + phosphate"}
{"X":53514,"RHEA_ID":55428,"DIRECTION":"UN","MASTER_ID":55428,"ec":"1.14.14.60","compounds":"ferruginol + O2 + reduced [NADPH--hemoprotein reductase] = 11-hydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53515,"RHEA_ID":52112,"compounds":"12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate"}
{"X":53516,"RHEA_ID":52113,"compounds":"12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA => 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate"}
{"X":53517,"RHEA_ID":62583,"compounds":"ATP + D-cystine(out) + H2O <=> ADP + D-cystine(in) + H(+) + phosphate"}
{"X":53518,"RHEA_ID":52115,"compounds":"12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA <=> 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate"}
{"X":53519,"RHEA_ID":52116,"compounds":"15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate"}
{"X":53520,"RHEA_ID":52117,"compounds":"15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA => 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate"}
{"X":53521,"RHEA_ID":62587,"compounds":"ATP + H2O + L-tyrosine(out) <=> ADP + H(+) + L-tyrosine(in) + phosphate"}
{"X":53522,"RHEA_ID":55436,"DIRECTION":"UN","MASTER_ID":55436,"ec":"1.14.14.62","compounds":"ferruginol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + salviol"}
{"X":53523,"RHEA_ID":52120,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53524,"RHEA_ID":52121,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53525,"RHEA_ID":62591,"compounds":"2-hydroxy-2-(4-hydroxyphenyl)acetate + H(+) <=> 4-hydroxybenzyl alcohol + CO2"}
{"X":53526,"RHEA_ID":62592,"DIRECTION":"UN","MASTER_ID":62592,"ec":"1.3.1.122","compounds":"(S)-8-oxocitronellyl enol + NADP(+) = (6E)-8-oxogeranial + H(+) + NADPH"}
{"X":53527,"RHEA_ID":52124,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53528,"RHEA_ID":62594,"DIRECTION":"RL","MASTER_ID":62592,"metacyc":"RXN-20745","compounds":"(6E)-8-oxogeranial + H(+) + NADPH => (S)-8-oxocitronellyl enol + NADP(+)"}
{"X":53529,"RHEA_ID":52126,"compounds":"(19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":53530,"RHEA_ID":62596,"DIRECTION":"UN","MASTER_ID":62596,"ec":"1.3.1.122","compounds":"(S)-8-oxocitronellyl enol + NAD(+) = (6E)-8-oxogeranial + H(+) + NADH"}
{"X":53531,"RHEA_ID":52128,"DIRECTION":"UN","MASTER_ID":52128,"ec":"3.6.1.71","compounds":"adenosine-5'-diphospho-5'-(DNA) + H2O = AMP + 2 H(+) + phospho-5'-(DNA)"}
{"X":53532,"RHEA_ID":52129,"DIRECTION":"LR","MASTER_ID":52128,"metacyc":"RXN-17914","compounds":"adenosine-5'-diphospho-5'-(DNA) + H2O => AMP + 2 H(+) + phospho-5'-(DNA)"}
{"X":53533,"RHEA_ID":52130,"compounds":"AMP + 2 H(+) + phospho-5'-(DNA) => adenosine-5'-diphospho-5'-(DNA) + H2O"}
{"X":53534,"RHEA_ID":62600,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = 5-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate"}
{"X":53535,"RHEA_ID":52132,"DIRECTION":"UN","MASTER_ID":52132,"ec":"3.6.1.71","compounds":"adenosine-5'-diphospho-5'-(ribonucleotide)-(DNA) + H2O = 5'-phospho-(ribonucleotide)-(DNA) + AMP + 2 H(+)"}
{"X":53536,"RHEA_ID":62602,"compounds":"5-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2"}
{"X":53537,"RHEA_ID":52134,"compounds":"5'-phospho-(ribonucleotide)-(DNA) + AMP + 2 H(+) => adenosine-5'-diphospho-5'-(ribonucleotide)-(DNA) + H2O"}
{"X":53538,"RHEA_ID":62604,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = 7-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate"}
{"X":53539,"RHEA_ID":62605,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => 7-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate"}
{"X":53540,"RHEA_ID":62606,"compounds":"7-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2"}
{"X":53541,"RHEA_ID":52138,"compounds":"GMP + 2 H(+) + phospho-5'-(DNA) => guanosine-5'-diphospho-5'-(DNA) + H2O"}
{"X":53542,"RHEA_ID":62608,"compounds":"glutathione + H(+) + hydrogen sulfide + ubiquinone-10 = S-sulfanylglutathione + ubiquinol-10"}
{"X":53543,"RHEA_ID":52140,"DIRECTION":"UN","MASTER_ID":52140,"ec":"3.6.1.72","compounds":"(DNA)-3'-diphospho-5'-guanosine + H2O = (DNA)-3'-phosphate + GMP + 2 H(+)"}
{"X":53544,"RHEA_ID":62610,"compounds":"S-sulfanylglutathione + ubiquinol-10 => glutathione + H(+) + hydrogen sulfide + ubiquinone-10"}
{"X":53545,"RHEA_ID":52142,"compounds":"(DNA)-3'-phosphate + GMP + 2 H(+) => (DNA)-3'-diphospho-5'-guanosine + H2O"}
{"X":53546,"RHEA_ID":55460,"DIRECTION":"UN","MASTER_ID":55460,"ec":"1.14.14.65","compounds":"11-hydroxyferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 11-hydroxysugiol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":53547,"RHEA_ID":62613,"compounds":"adenosine(1832) in 18S rRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine(1832) in 18S rRNA + S-adenosyl-L-homocysteine"}
{"X":53548,"RHEA_ID":62614,"compounds":"H(+) + N(6)-methyladenosine(1832) in 18S rRNA + S-adenosyl-L-homocysteine => adenosine(1832) in 18S rRNA + S-adenosyl-L-methionine"}
{"X":53549,"RHEA_ID":52146,"compounds":"(R)-2-(phosphonomethyl)malate + CoA + H(+) => 3-phosphonopyruvate + acetyl-CoA + H2O"}
{"X":53550,"RHEA_ID":55464,"DIRECTION":"UN","MASTER_ID":55464,"ec":"1.14.14.67","compounds":"11-hydroxysugiol + O2 + reduced [NADPH--hemoprotein reductase] = 11,20-dihydroxysugiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53551,"RHEA_ID":62617,"compounds":"a lactoside III(4)-a-Fuc-Lc4Cer + GDP-beta-L-fucose => a lactoside IV(2),III(4)-a-[Fuc]2-Lc4Cer + GDP + H(+)"}
{"X":53552,"RHEA_ID":52149,"DIRECTION":"LR","MASTER_ID":52148,"metacyc":"RXN-18178","compounds":"an (E)-omega-(methylsulfanyl)alkyl-thiohydroximate + UDP-alpha-D-glucose => an aliphatic desulfo-glucosinolate + UDP"}
{"X":53553,"RHEA_ID":52150,"compounds":"an aliphatic desulfo-glucosinolate + UDP => an (E)-omega-(methylsulfanyl)alkyl-thiohydroximate + UDP-alpha-D-glucose"}
{"X":53554,"RHEA_ID":62644,"compounds":"(5Z,8Z)-eicosadienoate + O2 = (5S)-hydroperoxy-(6E,8Z)-eicosadienoate"}
{"X":53555,"RHEA_ID":62645,"compounds":"(5Z,8Z)-eicosadienoate + O2 => (5S)-hydroperoxy-(6E,8Z)-eicosadienoate"}
{"X":53556,"RHEA_ID":55470,"compounds":"11,20-dihydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 11-hydroxyferruginol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":53557,"RHEA_ID":52154,"compounds":"indolylmethyl-desulfoglucosinolate + UDP => (E)-2-(1H-indol-3-yl)-1-thioacetohydroximate + UDP-alpha-D-glucose"}
{"X":53558,"RHEA_ID":62647,"compounds":"(5Z,8Z)-eicosadienoate + O2 <=> (5S)-hydroperoxy-(6E,8Z)-eicosadienoate"}
{"X":53559,"RHEA_ID":62649,"compounds":"(12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 => (5S)-hydroperoxy-(12S)-hydroxy-(6E,8Z,10E,14Z)-eicosatetraenoate"}
{"X":53560,"RHEA_ID":62650,"compounds":"(5S)-hydroperoxy-(12S)-hydroxy-(6E,8Z,10E,14Z)-eicosatetraenoate => (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2"}
{"X":53561,"RHEA_ID":52158,"compounds":"(R)-mandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":53562,"RHEA_ID":58819,"compounds":"ATP + L-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate"}
{"X":53563,"RHEA_ID":62653,"compounds":"acetyl-CoA + 6 H(+) + 6 malonyl-CoA => 6 CO2 + 7 CoA + H2O + YWA1"}
{"X":53564,"RHEA_ID":62654,"compounds":"6 CO2 + 7 CoA + H2O + YWA1 => acetyl-CoA + 6 H(+) + 6 malonyl-CoA"}
{"X":53565,"RHEA_ID":52162,"compounds":"(Z)-phenylacetaldehyde oxime => (E)-phenylacetaldehyde oxime"}
{"X":53566,"RHEA_ID":62656,"compounds":"2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + dimethylallyl diphosphate = 2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol + diphosphate"}
{"X":53567,"RHEA_ID":62657,"compounds":"2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + dimethylallyl diphosphate => 2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol + diphosphate"}
{"X":53568,"RHEA_ID":62658,"compounds":"2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol + diphosphate => 2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + dimethylallyl diphosphate"}
{"X":53569,"RHEA_ID":55482,"compounds":"ent-3beta-hydroxycassa-12,15-dien-2-one + 3 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]"}
{"X":53570,"RHEA_ID":58827,"compounds":"4 H(+) + luteothin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> aureothin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":53571,"RHEA_ID":62661,"compounds":"2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol => (2'R)-atrovenetin"}
{"X":53572,"RHEA_ID":62662,"compounds":"(2'R)-atrovenetin => 2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol"}
{"X":53573,"RHEA_ID":60024,"compounds":"(R,R)-chrysanthemyl diphosphate + H2O = (R,R)-chrysanthemol + diphosphate"}
{"X":53574,"RHEA_ID":62664,"compounds":"(2'R)-atrovenetin + S-adenosyl-L-methionine = deoxyherqueinone + H(+) + S-adenosyl-L-homocysteine"}
{"X":53575,"RHEA_ID":62665,"compounds":"(2'R)-atrovenetin + S-adenosyl-L-methionine => deoxyherqueinone + H(+) + S-adenosyl-L-homocysteine"}
{"X":53576,"RHEA_ID":62666,"compounds":"deoxyherqueinone + H(+) + S-adenosyl-L-homocysteine => (2'R)-atrovenetin + S-adenosyl-L-methionine"}
{"X":53577,"RHEA_ID":55490,"compounds":"ent-cassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":53578,"RHEA_ID":62668,"compounds":"deoxyherqueinone + H(+) + NADPH + O2 = H2O + herqueinone + NADP(+)"}
{"X":53579,"RHEA_ID":62669,"compounds":"deoxyherqueinone + H(+) + NADPH + O2 => H2O + herqueinone + NADP(+)"}
{"X":53580,"RHEA_ID":62670,"compounds":"H2O + herqueinone + NADP(+) => deoxyherqueinone + H(+) + NADPH + O2"}
{"X":53581,"RHEA_ID":52178,"compounds":"14,15-epoxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":53582,"RHEA_ID":52179,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 14,15-epoxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53583,"RHEA_ID":62673,"compounds":"a 2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-methionine => an N(6)-methyl-2'-O-methyladenosine in U2 snRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":53584,"RHEA_ID":62674,"compounds":"an N(6)-methyl-2'-O-methyladenosine in U2 snRNA + H(+) + S-adenosyl-L-homocysteine => a 2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-methionine"}
{"X":53585,"RHEA_ID":55498,"compounds":"ent-cassa-12,15-dien-2beta,3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":53586,"RHEA_ID":58843,"compounds":"cholesterol sulfate + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S)-hydroxycholesterol 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53587,"RHEA_ID":62677,"compounds":"10-formyldihydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-thiocarboxamide => 6-thio-IMP + 7,8-dihydrofolate + H2O"}
{"X":53588,"RHEA_ID":62678,"compounds":"6-thio-IMP + 7,8-dihydrofolate + H2O => 10-formyldihydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-thiocarboxamide"}
{"X":53589,"RHEA_ID":55502,"compounds":"ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2beta,3beta-ol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":53590,"RHEA_ID":58847,"compounds":"(6E)-8-hydroxygeranial + NAD(+) <=> (6E)-8-oxogeranial + H(+) + NADH"}
{"X":53591,"RHEA_ID":52188,"compounds":"1-aci-nitro-2-(1H-indol-3-yl)ethane + glutathione = (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O"}
{"X":53592,"RHEA_ID":62682,"compounds":"H(+) + H2O + norrubrofusarin => YWA1"}
{"X":53593,"RHEA_ID":55506,"compounds":"(5S,10S)-(9R)-7-drimene-11,12-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5S,9S,10S)-drim-7-en-11-ol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":53594,"RHEA_ID":58851,"compounds":"(6E)-8-hydroxygeraniol + NAD(+) <=> (6E)-8-hydroxygeranial + H(+) + NADH"}
{"X":53595,"RHEA_ID":62685,"DIRECTION":"LR","MASTER_ID":62684,"metacyc":"RXN-16923","compounds":"norrubrofusarin + S-adenosyl-L-methionine => H(+) + rubrofusarin + S-adenosyl-L-homocysteine"}
{"X":53596,"RHEA_ID":52193,"DIRECTION":"LR","MASTER_ID":52192,"metacyc":"RXN-18159","compounds":"(E)-phenylacetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] => (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53597,"RHEA_ID":62687,"compounds":"norrubrofusarin + S-adenosyl-L-methionine <=> H(+) + rubrofusarin + S-adenosyl-L-homocysteine"}
{"X":53598,"RHEA_ID":56640,"compounds":"1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+)"}
{"X":53599,"RHEA_ID":58856,"compounds":"(6E)-8-hydroxygeraniol + NAD(+) = (6E)-8-oxogeraniol + H(+) + NADH"}
{"X":53600,"RHEA_ID":52197,"DIRECTION":"LR","MASTER_ID":52196,"metacyc":"RXN-11412","compounds":"(E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] => 1-aci-nitro-2-(phenyl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53601,"RHEA_ID":52198,"compounds":"1-aci-nitro-2-(phenyl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":53602,"RHEA_ID":58859,"compounds":"(6E)-8-hydroxygeraniol + NAD(+) <=> (6E)-8-oxogeraniol + H(+) + NADH"}
{"X":53603,"RHEA_ID":55516,"compounds":"11-hydroxycucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase] = 11-oxocucurbitadienol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53604,"RHEA_ID":52201,"DIRECTION":"LR","MASTER_ID":52200,"metacyc":"RXN-11420","compounds":"1-aci-nitro-2-(phenyl)ethane + glutathione => (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O"}
{"X":53605,"RHEA_ID":56647,"compounds":"a uridine in mRNA <=> a pseudouridine in mRNA"}
{"X":53606,"RHEA_ID":58863,"compounds":"4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":53607,"RHEA_ID":62709,"DIRECTION":"LR","MASTER_ID":62708,"metacyc":"RXN-11655","compounds":"(indol-3-yl)butanoate + UDP-alpha-D-glucose => 4-(indol-3-yl)butanoyl-beta-D-glucose + UDP"}
{"X":53608,"RHEA_ID":52205,"DIRECTION":"LR","MASTER_ID":52204,"metacyc":"RXN-17547","compounds":"butachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => butyl formate + H2O + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":53609,"RHEA_ID":58867,"compounds":"4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":53610,"RHEA_ID":52208,"compounds":"alachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + methyl formate + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":53611,"RHEA_ID":52209,"DIRECTION":"LR","MASTER_ID":52208,"metacyc":"RXN-17548","compounds":"alachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + methyl formate + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":53612,"RHEA_ID":62715,"compounds":"betaenone C + H(+) + NADPH + O2 <=> H2O + NADP(+) + stemphyloxin I"}
{"X":53613,"RHEA_ID":62716,"compounds":"stemphyloxin I = stemphyloxin II"}
{"X":53614,"RHEA_ID":55528,"DIRECTION":"UN","MASTER_ID":55528,"ec":"4.1.1.108","compounds":"H(+) + H2O + L-tyrosine + O2 = (4-hydroxyphenyl)acetaldehyde + CO2 + H2O2 + NH4(+)"}
{"X":53615,"RHEA_ID":52213,"DIRECTION":"LR","MASTER_ID":52212,"metacyc":"RXN-17549","compounds":"acetochlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => ethyl formate + H2O + N-(2-ethyl-6-methylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":53616,"RHEA_ID":62719,"compounds":"stemphyloxin I <=> stemphyloxin II"}
{"X":53617,"RHEA_ID":52215,"compounds":"acetochlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> ethyl formate + H2O + N-(2-ethyl-6-methylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":53618,"RHEA_ID":52216,"DIRECTION":"UN","MASTER_ID":52216,"ec":"3.2.1.143","compounds":"[(1''->2')-ADP-alpha-D-ribose]n + H2O = [(1''->2')-ADP-alpha-D-ribose]n-1 + ADP-D-ribose"}
{"X":53619,"RHEA_ID":52217,"DIRECTION":"LR","MASTER_ID":52216,"metacyc":"3.2.1.143-RXN","compounds":"[(1''->2')-ADP-alpha-D-ribose]n + H2O => [(1''->2')-ADP-alpha-D-ribose]n-1 + ADP-D-ribose"}
{"X":53620,"RHEA_ID":62723,"compounds":"3 H(+) + 3 NADPH + 3 O2 + probetaenone I <=> betaenone B + 3 H2O + 3 NADP(+)"}
{"X":53621,"RHEA_ID":62724,"compounds":"(+)-premalbrancheamide + bromide + FAD + 2 H(+) = (+)-isomalbrancheamide C + FADH2"}
{"X":53622,"RHEA_ID":62725,"compounds":"(+)-premalbrancheamide + bromide + FAD + 2 H(+) => (+)-isomalbrancheamide C + FADH2"}
{"X":53623,"RHEA_ID":52225,"DIRECTION":"LR","MASTER_ID":52224,"metacyc":"RXN-18339","compounds":"3 AH2 + 3 H(+) + heme b + 3 O2 => 3 A + biliverdin delta + CO + Fe(2+) + 3 H2O"}
{"X":53624,"RHEA_ID":52226,"compounds":"3 A + biliverdin delta + CO + Fe(2+) + 3 H2O => 3 AH2 + 3 H(+) + heme b + 3 O2"}
{"X":53625,"RHEA_ID":56668,"DIRECTION":"UN","MASTER_ID":56668,"ec":"1.3.1.116","compounds":"7beta-hydroxy-3-oxochol-24-oyl-CoA + NAD(+) = 7beta-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH"}
{"X":53626,"RHEA_ID":52228,"DIRECTION":"UN","MASTER_ID":52228,"ec":"1.14.99.58","compounds":"3 AH2 + 2 H(+) + heme b + 3 O2 = 3 A + biliverdin beta + CO + Fe(2+) + 3 H2O"}
{"X":53627,"RHEA_ID":52229,"DIRECTION":"LR","MASTER_ID":52228,"metacyc":"RXN-18338","compounds":"3 AH2 + 2 H(+) + heme b + 3 O2 => 3 A + biliverdin beta + CO + Fe(2+) + 3 H2O"}
{"X":53628,"RHEA_ID":52230,"compounds":"3 A + biliverdin beta + CO + Fe(2+) + 3 H2O => 3 AH2 + 2 H(+) + heme b + 3 O2"}
{"X":53629,"RHEA_ID":58887,"compounds":"AH2 + alpha-N-dichloroacetyl-p-aminophenylserinol + 2 O2 <=> A + chloramphenicol + 2 H2O"}
{"X":53630,"RHEA_ID":62733,"compounds":"(+)-isomalbrancheamide B + bromide + FAD + 2 H(+) => (+)-isomalbrancheamide D + FADH2"}
{"X":53631,"RHEA_ID":52233,"DIRECTION":"LR","MASTER_ID":52232,"metacyc":"RXN-18346","compounds":"3 AH2 + 2 H(+) + heme b + 3 O2 => 3 A + Fe(2+) + 3 H2O + mycobilin a"}
{"X":53632,"RHEA_ID":62735,"compounds":"(+)-isomalbrancheamide B + bromide + FAD + 2 H(+) <=> (+)-isomalbrancheamide D + FADH2"}
{"X":53633,"RHEA_ID":55547,"compounds":"L-lysyl-[citrate synthase] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine"}
{"X":53634,"RHEA_ID":62737,"compounds":"1-hydroxy-3-(1H-indol-3-ylmethyl)-6H,7H,8H-5lambda5-pyrrolo[1,2-a]pyrazin-5-ylium + dimethylallyl diphosphate => 1-hydroxy-3-{[2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl]methyl}-6H,7H,8H-5lambda5-pyrrolo[1,2-a]pyrazine + diphosphate"}
{"X":53635,"RHEA_ID":52237,"DIRECTION":"LR","MASTER_ID":52236,"metacyc":"RXN-18347","compounds":"3 AH2 + 2 H(+) + heme b + 3 O2 => 3 A + Fe(2+) + 3 H2O + mycobilin b"}
{"X":53636,"RHEA_ID":52238,"compounds":"3 A + Fe(2+) + 3 H2O + mycobilin b => 3 AH2 + 2 H(+) + heme b + 3 O2"}
{"X":53637,"RHEA_ID":58903,"compounds":"1-carboxybiuret + H2O <=> NH4(+) + urea-1,3-dicarboxylate"}
{"X":53638,"RHEA_ID":58904,"DIRECTION":"UN","MASTER_ID":58904,"ec":"2.3.1.287","compounds":"8 (S)-methylmalonyl-CoA + 24 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 16 NADPH = C40-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+)"}
{"X":53639,"RHEA_ID":52241,"DIRECTION":"LR","MASTER_ID":52240,"metacyc":"RXN-18154","compounds":"2 H2O + 2 Mn(2+) + O2 => 4 H(+) + 2 MnO2"}
{"X":53640,"RHEA_ID":62743,"compounds":"(8aS)-3-[(1H-indol-3-yl)methyl]-1H,2H,6H,7H,8H,8aH-pyrrolo[1,2-a]pyrazin-1-one + A + H(+) <=> 1-hydroxy-3-(1H-indol-3-ylmethyl)-6H,7H,8H-5lambda5-pyrrolo[1,2-a]pyrazin-5-ylium + AH2"}
{"X":53641,"RHEA_ID":52244,"compounds":"4 H(+) + 4 Mn(2+) + O2 = 2 H2O + 4 Mn(3+)"}
{"X":53642,"RHEA_ID":52245,"DIRECTION":"LR","MASTER_ID":52244,"metacyc":"RXN-11646","compounds":"4 H(+) + 4 Mn(2+) + O2 => 2 H2O + 4 Mn(3+)"}
{"X":53643,"RHEA_ID":52246,"compounds":"2 H2O + 4 Mn(3+) => 4 H(+) + 4 Mn(2+) + O2"}
{"X":53644,"RHEA_ID":55560,"DIRECTION":"UN","MASTER_ID":55560,"ec":"5.4.4.7","compounds":"a hydroperoxyeicosatetraenoate = a hydroxy epoxy eicosatetraenoate"}
{"X":53645,"RHEA_ID":52249,"DIRECTION":"LR","MASTER_ID":52248,"metacyc":"RXN-11645","compounds":"6 H2O + 4 Mn(3+) + O2 => 12 H(+) + 4 MnO2"}
{"X":53646,"RHEA_ID":62763,"compounds":"4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":53647,"RHEA_ID":55564,"DIRECTION":"UN","MASTER_ID":55564,"ec":"2.7.1.222","compounds":"4-hydroxytryptamine + ATP = 4-hydoxytryptamine 4-phosphate + ADP + H(+)"}
{"X":53648,"RHEA_ID":52253,"compounds":"a bacteriochlorophyllide c + H2O + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + a bacteriochlorophyllide e + 2 H(+) + 2 L-methionine"}
{"X":53649,"RHEA_ID":62767,"compounds":"4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":53650,"RHEA_ID":62768,"compounds":"4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}
{"X":53651,"RHEA_ID":62769,"DIRECTION":"LR","MASTER_ID":62768,"metacyc":"RXN-20440","compounds":"4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}
{"X":53652,"RHEA_ID":52257,"DIRECTION":"LR","MASTER_ID":52256,"metacyc":"RXN-18412","compounds":"a 7(1)-hydroxybacteriochlorophyllide c + H2O + S-adenosyl-L-methionine => 5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide c + H(+) + L-methionine"}
{"X":53653,"RHEA_ID":58922,"compounds":"(+)-medicarpin + H2O => (3S,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol"}
{"X":53654,"RHEA_ID":58923,"compounds":"(3S,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol <=> (+)-medicarpin + H2O"}
{"X":53655,"RHEA_ID":58924,"DIRECTION":"UN","MASTER_ID":58924,"ec":"4.2.1.139","compounds":"(3R,4R)-3-(6-hydroxy-1,3-benzodioxol-5-yl)-3,4-dihydro-2H-chromene-4,7-diol = (-)-maackiain + H2O"}
{"X":53656,"RHEA_ID":52261,"DIRECTION":"LR","MASTER_ID":52260,"metacyc":"RXN-17455","compounds":"a 7(1),7(1)-dihydroxybacteriochlorophyllide c => a bacteriochlorophyllide e + H2O"}
{"X":53657,"RHEA_ID":58926,"compounds":"(-)-maackiain + H2O => (3R,4R)-3-(6-hydroxy-1,3-benzodioxol-5-yl)-3,4-dihydro-2H-chromene-4,7-diol"}
{"X":53658,"RHEA_ID":62781,"compounds":"4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}
{"X":53659,"RHEA_ID":52265,"DIRECTION":"LR","MASTER_ID":52264,"metacyc":"RXN-18224","compounds":"3-(aminomethyl)indole + 2 S-adenosyl-L-methionine => gramine + 2 H(+) + 2 S-adenosyl-L-homocysteine"}
{"X":53660,"RHEA_ID":62783,"compounds":"4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}
{"X":53661,"RHEA_ID":58931,"compounds":"(3R,4R)-7,2',4'-trihydroxyisoflavanol <=> (6aR,11aR)-3,9-dihydroxypterocarpan + H2O"}
{"X":53662,"RHEA_ID":58932,"DIRECTION":"UN","MASTER_ID":58932,"ec":"2.3.1.289","compounds":"4 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 8 H(+) + malonyl-CoA + 4 NADPH = 5 CO2 + 6 CoA + demethylluteothin + 3 H2O + 4 NADP(+)"}
{"X":53663,"RHEA_ID":57821,"compounds":"[phosphate](n) + ADP => [phosphate](n+1) + AMP"}
{"X":53664,"RHEA_ID":58934,"compounds":"5 CO2 + 6 CoA + demethylluteothin + 3 H2O + 4 NADP(+) => 4 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 8 H(+) + malonyl-CoA + 4 NADPH"}
{"X":53665,"RHEA_ID":53378,"DIRECTION":"RL","MASTER_ID":53376,"metacyc":"RXN-12454","compounds":"H(+) + NADPH + uridine(16) in tRNA => 5,6-dihydrouridine(16) in tRNA + NADP(+)"}
{"X":53666,"RHEA_ID":52272,"compounds":"(1H-indol-3-yl)-N-methylmethanamine + S-adenosyl-L-methionine = gramine + H(+) + S-adenosyl-L-homocysteine"}
{"X":53667,"RHEA_ID":55585,"DIRECTION":"LR","MASTER_ID":55584,"metacyc":"RXN-19346","compounds":"adenosine in mRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine in mRNA + S-adenosyl-L-homocysteine"}
{"X":53668,"RHEA_ID":58938,"compounds":"all-trans-lycopaoctaene + 2 diphosphate + NAD(+) => 2 all-trans-geranylgeranyl diphosphate + H(+) + NADH"}
{"X":53669,"RHEA_ID":58939,"compounds":"2 all-trans-geranylgeranyl diphosphate + H(+) + NADH <=> all-trans-lycopaoctaene + 2 diphosphate + NAD(+)"}
{"X":53670,"RHEA_ID":58940,"compounds":"(1R,2R,3R)-prephytoene diphosphate + H(+) + NADH = all-trans-lycopaoctaene + diphosphate + NAD(+)"}
{"X":53671,"RHEA_ID":57829,"compounds":"dIMP + H2O => 2-deoxy-D-ribose 5-phosphate + hypoxanthine"}
{"X":53672,"RHEA_ID":55590,"compounds":"a 1,2-diacyl-sn-glycerol + inositol phosphoceramide => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-acyl-sphingoid base"}
{"X":53673,"RHEA_ID":55591,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-acyl-sphingoid base <=> a 1,2-diacyl-sn-glycerol + inositol phosphoceramide"}
{"X":53674,"RHEA_ID":58944,"DIRECTION":"UN","MASTER_ID":58944,"ec":"2.3.1.290","compounds":"6 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 12 H(+) + malonyl-CoA + 6 NADPH = 7 CO2 + 8 CoA + demethyldeoxyspectinabilin + 5 H2O + 6 NADP(+)"}
{"X":53675,"RHEA_ID":57833,"DIRECTION":"LR","MASTER_ID":57832,"metacyc":"RXN-8182","compounds":"5-oxopentanoate + H2O + NADP(+) => glutarate + 2 H(+) + NADPH"}
{"X":53676,"RHEA_ID":58946,"compounds":"7 CO2 + 8 CoA + demethyldeoxyspectinabilin + 5 H2O + 6 NADP(+) => 6 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 12 H(+) + malonyl-CoA + 6 NADPH"}
{"X":53677,"RHEA_ID":55595,"compounds":"2 (3R)-hydroxydecanoyl-[ACP] + H2O <=> (3R)-3-[(3R)-3-hydroxydecanoyloxy]decanoate + H(+) + 2 holo-[ACP]"}
{"X":53678,"RHEA_ID":61414,"compounds":"ADP + H(+) + N-(3-O-phospho-D-erythrulosyl)-cadaverine => ATP + N-(D-erythrulosyl)-cadaverine"}
{"X":53679,"RHEA_ID":52285,"compounds":"(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] => 11-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53680,"RHEA_ID":58950,"compounds":"4-O-([3-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP => 4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine"}
{"X":53681,"RHEA_ID":52287,"compounds":"(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53682,"RHEA_ID":55600,"compounds":"an inositol-1-phosphoceramide + GDP-alpha-D-mannose = a mannosylinositol-1-phosphoceramide + GDP + H(+)"}
{"X":53683,"RHEA_ID":52289,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53684,"RHEA_ID":56731,"compounds":"4-hydroxy-all-trans-beta-carotene + AH2 + O2 <=> 4,4-dihydroxy-all-trans-beta-carotene + A + H2O"}
{"X":53685,"RHEA_ID":52291,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53686,"RHEA_ID":55604,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-acyl-sphingoid base = a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-acylsphingoid base"}
{"X":53687,"RHEA_ID":52293,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53688,"RHEA_ID":58958,"compounds":"a 2'-O-methylribonucleotide in RNA + H(+) + S-adenosyl-L-homocysteine => a ribonucleotide in RNA + S-adenosyl-L-methionine"}
{"X":53689,"RHEA_ID":55607,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-acyl-sphingoid base <=> a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-acylsphingoid base"}
{"X":53690,"RHEA_ID":58960,"compounds":"benzaldehyde + H2O + O2 = benzoate + H(+) + H2O2"}
{"X":53691,"RHEA_ID":52297,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53692,"RHEA_ID":58962,"compounds":"benzoate + H(+) + H2O2 => benzaldehyde + H2O + O2"}
{"X":53693,"RHEA_ID":58963,"compounds":"benzaldehyde + H2O + O2 <=> benzoate + H(+) + H2O2"}
{"X":53694,"RHEA_ID":58964,"compounds":"H2O + hexanal + O2 = H(+) + H2O2 + hexanoate"}
{"X":53695,"RHEA_ID":52301,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53696,"RHEA_ID":58966,"compounds":"H(+) + H2O2 + hexanoate => H2O + hexanal + O2"}
{"X":53697,"RHEA_ID":55619,"DIRECTION":"BI","MASTER_ID":55616,"metacyc":"RXN-12495","compounds":"a carotenoid psi-end group <=> a carotenoid epsilon-end group"}
{"X":53698,"RHEA_ID":58968,"compounds":"1-naphthaldehyde + H2O + O2 = 1-naphthoate + H(+) + H2O2"}
{"X":53699,"RHEA_ID":52305,"DIRECTION":"LR","MASTER_ID":52304,"metacyc":"RXN-18397","compounds":"H2O + L-ectoine => (2S)-2-acetamido-4-aminobutanoate"}
{"X":53700,"RHEA_ID":56747,"compounds":"2-oxoglutarate + L-arginyl-[protein] + O2 <=> (3R)-3-hydroxy-L-arginyl-[protein] + CO2 + succinate"}
{"X":53701,"RHEA_ID":53414,"compounds":"(4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+) => (1R,4S)-1-hydroxylimonen-2-one + H(+) + NADPH + O2"}
{"X":53702,"RHEA_ID":55632,"compounds":"1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)"}
{"X":53703,"RHEA_ID":52309,"compounds":"2-hydroxyglutarate + NADP(+) => 2-oxoglutarate + H(+) + NADPH"}
{"X":53704,"RHEA_ID":58974,"compounds":"4-hydroxy-3-methoxybenzoate + H(+) + H2O2 => H2O + O2 + vanillin"}
{"X":53705,"RHEA_ID":55635,"compounds":"1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)"}
{"X":53706,"RHEA_ID":52312,"compounds":"NAD(+) + thromboxane B2 = 11-dehydro-thromboxane B2 + H(+) + NADH"}
{"X":53707,"RHEA_ID":52313,"DIRECTION":"LR","MASTER_ID":52312,"reactome":"R-HSA-2161732.2","compounds":"NAD(+) + thromboxane B2 => 11-dehydro-thromboxane B2 + H(+) + NADH"}
{"X":53708,"RHEA_ID":52314,"compounds":"11-dehydro-thromboxane B2 + H(+) + NADH => NAD(+) + thromboxane B2"}
{"X":53709,"RHEA_ID":55639,"compounds":"ATP + C-terminal L-cysteinyl-[HypE protein] + carbamoyl phosphate + H2O <=> AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + diphosphate + H(+) + phosphate"}
{"X":53710,"RHEA_ID":58980,"compounds":"citral + H2O + O2 = 3,7-dimethylocta-2,6-dienoate + H(+) + H2O2"}
{"X":53711,"RHEA_ID":52317,"compounds":"a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate => an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+)"}
{"X":53712,"RHEA_ID":56759,"compounds":"5 H(+) + 3 O2 + obtusifoliol + 6 reduced [2Fe-2S]-[ferredoxin] <=> 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":53713,"RHEA_ID":58983,"compounds":"citral + H2O + O2 <=> 3,7-dimethylocta-2,6-dienoate + H(+) + H2O2"}
{"X":53714,"RHEA_ID":58984,"compounds":"acrolein + H2O + O2 = acrylate + H(+) + H2O2"}
{"X":53715,"RHEA_ID":52321,"DIRECTION":"LR","MASTER_ID":52320,"metacyc":"RXN-8707","compounds":"O2 + reduced [NADPH--hemoprotein reductase] + tryptamine => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + serotonin"}
{"X":53716,"RHEA_ID":58986,"compounds":"acrylate + H(+) + H2O2 => acrolein + H2O + O2"}
{"X":53717,"RHEA_ID":55647,"compounds":"ATP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] <=> ADP + C-terminal S-cyanate-L-cysteinyl-[HypE protein] + H(+) + phosphate"}
{"X":53718,"RHEA_ID":58988,"compounds":"(E)-4-hydroxynon-2-enal + H2O + O2 = (E)-4-hydroxynon-2-enoate + H(+) + H2O2"}
{"X":53719,"RHEA_ID":55649,"compounds":"2-oxoglutarate + O2 + validoxylamine A => CO2 + H(+) + succinate + validoxylamine B"}
{"X":53720,"RHEA_ID":57877,"compounds":"uridine(54) in tRNA => pseudouridine(54) in tRNA"}
{"X":53721,"RHEA_ID":53434,"compounds":"a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose"}
{"X":53722,"RHEA_ID":55652,"compounds":"1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate"}
{"X":53723,"RHEA_ID":52329,"DIRECTION":"LR","MASTER_ID":52328,"metacyc":"RXN-13566","compounds":"L-arginine + O2 + reduced [flavodoxin] => H(+) + H2O + N(omega)-hydroxy-L-arginine + oxidized [flavodoxin]"}
{"X":53724,"RHEA_ID":52330,"compounds":"H(+) + H2O + N(omega)-hydroxy-L-arginine + oxidized [flavodoxin] => L-arginine + O2 + reduced [flavodoxin]"}
{"X":53725,"RHEA_ID":58995,"compounds":"cinnamaldehyde + H2O + O2 <=> cinnamate + H(+) + H2O2"}
{"X":53726,"RHEA_ID":55656,"DIRECTION":"UN","MASTER_ID":55656,"ec":"1.3.99.40","compounds":"2 A + a carotenoid beta-end derivative = a carotenoid chi-end derivative + 2 AH2"}
{"X":53727,"RHEA_ID":52333,"DIRECTION":"LR","MASTER_ID":52332,"metacyc":"RXN-13567","compounds":"2 N(omega)-hydroxy-L-arginine + 2 O2 + reduced [flavodoxin] => 3 H(+) + 2 H2O + 2 L-citrulline + 2 nitric oxide + oxidized [flavodoxin]"}
{"X":53728,"RHEA_ID":55658,"compounds":"a carotenoid chi-end derivative + 2 AH2 => 2 A + a carotenoid beta-end derivative"}
{"X":53729,"RHEA_ID":58999,"compounds":"H2O + indole-3-carbaldehyde + O2 <=> H(+) + H2O2 + indole-3-carboxylate"}
{"X":53730,"RHEA_ID":55660,"DIRECTION":"UN","MASTER_ID":55660,"ec":"1.14.99.63","compounds":"2 AH2 + all-trans-beta-carotene + 2 O2 = 2 A + echinenone + 3 H2O"}
{"X":53731,"RHEA_ID":53444,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 11beta,17beta-dihydroxyandrost-4-ene-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53732,"RHEA_ID":52338,"compounds":"a long-chain acyl-AMP + diphosphate => a long-chain fatty acid + ATP + H(+)"}
{"X":53733,"RHEA_ID":53446,"compounds":"11beta,17beta-dihydroxyandrost-4-ene-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone"}
{"X":53734,"RHEA_ID":52340,"compounds":"a holo-[mycocerosate synthase] + a long-chain acyl-AMP = a long-chain acyl-[mycocerosate synthase] + AMP + H(+)"}
{"X":53735,"RHEA_ID":52341,"DIRECTION":"LR","MASTER_ID":52340,"metacyc":"RXN-18532","compounds":"a holo-[mycocerosate synthase] + a long-chain acyl-AMP => a long-chain acyl-[mycocerosate synthase] + AMP + H(+)"}
{"X":53736,"RHEA_ID":52342,"compounds":"a long-chain acyl-[mycocerosate synthase] + AMP + H(+) => a holo-[mycocerosate synthase] + a long-chain acyl-AMP"}
{"X":53737,"RHEA_ID":59007,"compounds":"dodecanal + H2O + O2 <=> dodecanoate + H(+) + H2O2"}
{"X":53738,"RHEA_ID":59008,"compounds":"H2O + O2 + salicylaldehyde = H(+) + H2O2 + salicylate"}
{"X":53739,"RHEA_ID":59009,"compounds":"H2O + O2 + salicylaldehyde => H(+) + H2O2 + salicylate"}
{"X":53740,"RHEA_ID":52346,"compounds":"(24S)-hydroxycholesterol 24-sulfate + adenosine 3',5'-bisphosphate + H(+) => (24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate"}
{"X":53741,"RHEA_ID":55671,"compounds":"11-cis-retinol--[retinol-binding protein] + NAD(+) <=> 11-cis-retinal--[retinol-binding protein] + H(+) + NADH"}
{"X":53742,"RHEA_ID":52348,"compounds":"(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate = (24S)-hydroxycholesterol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)"}
{"X":53743,"RHEA_ID":59013,"DIRECTION":"LR","MASTER_ID":59012,"metacyc":"RXN-4021","compounds":"cycloartenol + S-adenosyl-L-methionine => 24-methylenecycloartanol + H(+) + S-adenosyl-L-homocysteine"}
{"X":53744,"RHEA_ID":56791,"compounds":"apo-[corrinoid adenosyltransferase] + cob(II)alamin <=> cob(II)alamin--[corrinoid adenosyltransferase]"}
{"X":53745,"RHEA_ID":59015,"compounds":"cycloartenol + S-adenosyl-L-methionine <=> 24-methylenecycloartanol + H(+) + S-adenosyl-L-homocysteine"}
{"X":53746,"RHEA_ID":52352,"compounds":"(24S)-hydroxycholesterol 24-sulfate + 3'-phosphoadenylyl sulfate = (24S)-hydroxycholesterol 3,24-disulfate + adenosine 3',5'-bisphosphate + H(+)"}
{"X":53747,"RHEA_ID":59017,"DIRECTION":"LR","MASTER_ID":59016,"metacyc":"RXN-11928","compounds":"4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + NAD(+) => CO2 + cycloeucalenone + NADH"}
{"X":53748,"RHEA_ID":52354,"compounds":"(24S)-hydroxycholesterol 3,24-disulfate + adenosine 3',5'-bisphosphate + H(+) => (24S)-hydroxycholesterol 24-sulfate + 3'-phosphoadenylyl sulfate"}
{"X":53749,"RHEA_ID":59019,"compounds":"4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + NAD(+) <=> CO2 + cycloeucalenone + NADH"}
{"X":53750,"RHEA_ID":52356,"compounds":"3'-phosphoadenylyl sulfate + pregnenolone = adenosine 3',5'-bisphosphate + H(+) + pregnenolone sulfate"}
{"X":53751,"RHEA_ID":59021,"compounds":"1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O => (9Z,12Z)-octadecadienoate + di-(9Z,12Z)-octadecadienoylglycerol + H(+)"}
{"X":53752,"RHEA_ID":55694,"compounds":"1D-myo-inositol 1-phosphate + H(+) + N-acyl-sphingoid base => H2O + inositol phosphoceramide"}
{"X":53753,"RHEA_ID":52359,"compounds":"3'-phosphoadenylyl sulfate + pregnenolone <=> adenosine 3',5'-bisphosphate + H(+) + pregnenolone sulfate"}
{"X":53754,"RHEA_ID":52368,"compounds":"3'-phosphoadenylyl sulfate + cholesterol = adenosine 3',5'-bisphosphate + cholesterol sulfate + H(+)"}
{"X":53755,"RHEA_ID":52369,"DIRECTION":"LR","MASTER_ID":52368,"metacyc":"RXN66-602","reactome":"R-HSA-176609.2","compounds":"3'-phosphoadenylyl sulfate + cholesterol => adenosine 3',5'-bisphosphate + cholesterol sulfate + H(+)"}
{"X":53756,"RHEA_ID":56803,"compounds":"apo-[corrinoid adenosyltransferase] + cob(II)yrinate a,c diamide <=> cob(II)yrinate a,c diamide--[corrinoid adenosyltransferase]"}
{"X":53757,"RHEA_ID":55699,"compounds":"a mannosylinositol-1-phospho-N-acyl-sphingoid base + H2O <=> H(+) + mannosylinositol-1-phosphate + N-acyl-sphingoid base"}
{"X":53758,"RHEA_ID":52372,"compounds":"17beta-estradiol + 3'-phosphoadenylyl sulfate = 17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)"}
{"X":53759,"RHEA_ID":55701,"compounds":"an inositol phosphomannosylinositol-1-phospho-N-acyl-(4R)-4-hydroxysphinganine + H2O => an N-acyl-(4R)-4-hydroxysphinganine + H(+) + mannosyldiinositol-1-phosphate"}
{"X":53760,"RHEA_ID":52374,"compounds":"17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+) => 17beta-estradiol + 3'-phosphoadenylyl sulfate"}
{"X":53761,"RHEA_ID":59031,"compounds":"(Z)-24-ethylidenelophenol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}
{"X":53762,"RHEA_ID":52376,"DIRECTION":"UN","MASTER_ID":52376,"ec":"2.1.5.1","compounds":"(+)-sesamin monocatechol + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n = (+)-sesamin dicatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n)"}
{"X":53763,"RHEA_ID":57920,"compounds":"4-phosphooxy-L-aspartyl-tRNA(Asn) + NH4(+) = H(+) + L-asparaginyl-tRNA(Asn) + phosphate"}
{"X":53764,"RHEA_ID":56811,"compounds":"ATP + cob(I)yrinate a,c diamide--[corrinoid adenosyltransferase] <=> adenosylcob(III)yrinate a,c-diamide + apo-[corrinoid adenosyltransferase] + triphosphate"}
{"X":53765,"RHEA_ID":59035,"compounds":"(Z)-24-ethylidenelophenol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":53766,"RHEA_ID":56813,"DIRECTION":"LR","MASTER_ID":56812,"metacyc":"RXN-19538","compounds":"2-oxoglutarate + chloride + H(+) + L-threonyl-[peptidyl-carrier protein] + O2 => 4-chloro-L-threonyl-[peptidyl-carrier protein] + CO2 + H2O + succinate"}
{"X":53767,"RHEA_ID":53480,"compounds":"3beta-hydroxy-5alpha-androstan-17-one + H(+) + NADPH = 5alpha-androstane-3beta,17beta-diol + NADP(+)"}
{"X":53768,"RHEA_ID":60235,"compounds":"2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + succinate"}
{"X":53769,"RHEA_ID":59039,"compounds":"4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":53770,"RHEA_ID":56817,"DIRECTION":"LR","MASTER_ID":56816,"ecocyc":"RIBOSYLPYRIMIDINE-NUCLEOSIDASE-RXN","metacyc":"RIBOSYLPYRIMIDINE-NUCLEOSIDASE-RXN","compounds":"a pyrimidine ribonucleoside + H2O => a pyrimidine nucleobase + D-ribose"}
{"X":53771,"RHEA_ID":59041,"DIRECTION":"LR","MASTER_ID":59040,"metacyc":"RXN-11937","compounds":"4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 => 4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":53772,"RHEA_ID":60239,"compounds":"2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 2 O2 <=> 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + 2 succinate"}
{"X":53773,"RHEA_ID":59043,"compounds":"4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":53774,"RHEA_ID":52388,"DIRECTION":"UN","MASTER_ID":52388,"ec":"2.7.1.219","compounds":"ATP + D-threonate = 4-O-phospho-D-threonate + ADP + H(+)"}
{"X":53775,"RHEA_ID":59045,"DIRECTION":"LR","MASTER_ID":59044,"metacyc":"RXN-19702","compounds":"dammarenediol-II + UDP-alpha-D-glucose => (20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + H(+) + UDP"}
{"X":53776,"RHEA_ID":60243,"compounds":"2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + succinate"}
{"X":53777,"RHEA_ID":55719,"compounds":"(S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(2'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O <=> (9Z)-octadecenoate + (S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+)"}
{"X":53778,"RHEA_ID":52392,"DIRECTION":"UN","MASTER_ID":52392,"ec":"2.7.1.220","compounds":"ATP + D-erythronate = 4-phospho-D-erythronate + ADP + H(+)"}
{"X":53779,"RHEA_ID":53492,"DIRECTION":"UN","MASTER_ID":53492,"ec":"2.1.1.86","compounds":"5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na(+)(out)"}
{"X":53780,"RHEA_ID":60247,"compounds":"2 A + 2 H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] <=> 2 AH2 + 2 formaldehyde + L-lysyl(4)-[histone H3]"}
{"X":53781,"RHEA_ID":56828,"DIRECTION":"UN","MASTER_ID":56828,"ec":"1.21.4.5","compounds":"2,3,6-trichlorohydroquinone + chloride + glutathione disulfide = 2,3,5,6-tetrachlorohydroquinone + 2 glutathione"}
{"X":53782,"RHEA_ID":52396,"DIRECTION":"UN","MASTER_ID":52396,"ec":"1.1.1.408","compounds":"4-O-phospho-D-threonate + NAD(+) = CO2 + dihydroxyacetone phosphate + NADH"}
{"X":53783,"RHEA_ID":59053,"DIRECTION":"LR","MASTER_ID":59052,"metacyc":"RXN-20176","compounds":"D-lysine + H(+) => cadaverine + CO2"}
{"X":53784,"RHEA_ID":60251,"compounds":"A + H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] <=> AH2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3]"}
{"X":53785,"RHEA_ID":59055,"compounds":"D-lysine + H(+) <=> cadaverine + CO2"}
{"X":53786,"RHEA_ID":52400,"compounds":"4-O-phospho-D-threonate + NAD(+) = 3-dehydro-4-O-phospho-L-erythronate + H(+) + NADH"}
{"X":53787,"RHEA_ID":52401,"DIRECTION":"LR","MASTER_ID":52400,"metacyc":"RXN-18599","compounds":"4-O-phospho-D-threonate + NAD(+) => 3-dehydro-4-O-phospho-L-erythronate + H(+) + NADH"}
{"X":53788,"RHEA_ID":53501,"compounds":"1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O => 1-hexanoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)"}
{"X":53789,"RHEA_ID":60256,"compounds":"A + H2O + N(6)-methyl-L-lysyl(4)-[histone H3] = AH2 + formaldehyde + L-lysyl(4)-[histone H3]"}
{"X":53790,"RHEA_ID":52404,"DIRECTION":"UN","MASTER_ID":52404,"ec":"4.1.1.104","compounds":"3-dehydro-4-O-phospho-L-erythronate + H(+) = CO2 + dihydroxyacetone phosphate"}
{"X":53791,"RHEA_ID":55733,"DIRECTION":"LR","MASTER_ID":55732,"metacyc":"RXN-18536","compounds":"19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] => 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)"}
{"X":53792,"RHEA_ID":59062,"compounds":"(20S)-ginsenoside Rh2 + D-glucose => (20S)-ginsenoside Rg3 + H2O"}
{"X":53793,"RHEA_ID":60260,"DIRECTION":"UN","MASTER_ID":60260,"ec":"2.1.1.354","compounds":"L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine"}
{"X":53794,"RHEA_ID":52408,"DIRECTION":"UN","MASTER_ID":52408,"ec":"1.1.1.409","compounds":"4-phospho-D-erythronate + NAD(+) = CO2 + dihydroxyacetone phosphate + NADH"}
{"X":53795,"RHEA_ID":59065,"DIRECTION":"LR","MASTER_ID":59064,"metacyc":"RXN-20209","compounds":"demethylluteothin + S-adenosyl-L-methionine => luteothin + S-adenosyl-L-homocysteine"}
{"X":53796,"RHEA_ID":59066,"compounds":"luteothin + S-adenosyl-L-homocysteine => demethylluteothin + S-adenosyl-L-methionine"}
{"X":53797,"RHEA_ID":59067,"compounds":"demethylluteothin + S-adenosyl-L-methionine <=> luteothin + S-adenosyl-L-homocysteine"}
{"X":53798,"RHEA_ID":52412,"compounds":"4-phospho-D-erythronate + NAD(+) = 3-dehydro-4-O-phospho-D-erythronate + H(+) + NADH"}
{"X":53799,"RHEA_ID":59069,"DIRECTION":"LR","MASTER_ID":59068,"metacyc":"RXN-20209","compounds":"demethyldeoxyspectinabilin + S-adenosyl-L-methionine => deoxyspectinabilin + S-adenosyl-L-homocysteine"}
{"X":53800,"RHEA_ID":55742,"compounds":"D-glucose + oleuropein aglycone => H2O + oleuropein"}
{"X":53801,"RHEA_ID":56848,"DIRECTION":"UN","MASTER_ID":56848,"ec":"2.1.1.349","compounds":"1,6-didemethyltoxoflavin + S-adenosyl-L-methionine = H(+) + reumycin + S-adenosyl-L-homocysteine"}
{"X":53802,"RHEA_ID":56849,"DIRECTION":"LR","MASTER_ID":56848,"metacyc":"RXN-19530","compounds":"1,6-didemethyltoxoflavin + S-adenosyl-L-methionine => H(+) + reumycin + S-adenosyl-L-homocysteine"}
{"X":53803,"RHEA_ID":59073,"DIRECTION":"LR","MASTER_ID":59072,"metacyc":"RXN-9010","compounds":"AH2 + cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + 2 S-adenosyl-L-methionine => 5'-deoxyadenosine + A + cytidine 5'-{[hydroxy(2-hydroxypropyl)phosphonoyl]phosphate} + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine"}
{"X":53804,"RHEA_ID":55746,"DIRECTION":"RL","MASTER_ID":55744,"metacyc":"RXN-18528","compounds":"coenzyme M-coenzyme B heterodisulfide + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 reduced coenzyme F420-(gamma-Glu)(n) => coenzyme B + coenzyme M + 4 H(+) + 2 oxidized coenzyme F420-(gamma-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":53805,"RHEA_ID":56852,"DIRECTION":"UN","MASTER_ID":56852,"ec":"2.1.1.349","compounds":"reumycin + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + toxoflavin"}
{"X":53806,"RHEA_ID":56853,"DIRECTION":"LR","MASTER_ID":56852,"metacyc":"RXN-19529","compounds":"reumycin + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + toxoflavin"}
{"X":53807,"RHEA_ID":53519,"compounds":"1-hexadecanoyl-2-(11Z,14Z,17Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (11Z,14Z,17Z)-eicosatrienoate"}
{"X":53808,"RHEA_ID":60275,"compounds":"N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":53809,"RHEA_ID":56856,"DIRECTION":"UN","MASTER_ID":56856,"ec":"1.2.99.6","compounds":"A + an aldehyde + H2O = a carboxylate + AH2 + H(+)"}
{"X":53810,"RHEA_ID":59080,"compounds":"bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose = 2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+)"}
{"X":53811,"RHEA_ID":59081,"DIRECTION":"LR","MASTER_ID":59080,"metacyc":"RXN-19965","compounds":"bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose => 2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+)"}
{"X":53812,"RHEA_ID":55754,"DIRECTION":"RL","MASTER_ID":55752,"metacyc":"RXN-18529","compounds":"coenzyme M-coenzyme B heterodisulfide + 2 formate + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 CO2 + coenzyme B + coenzyme M + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":53813,"RHEA_ID":59083,"compounds":"bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose <=> 2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+)"}
{"X":53814,"RHEA_ID":59084,"compounds":"2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose = 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+)"}
{"X":53815,"RHEA_ID":59085,"DIRECTION":"LR","MASTER_ID":59084,"metacyc":"RXN-19966","compounds":"2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose => 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+)"}
{"X":53816,"RHEA_ID":55758,"compounds":"a 2-hydroxyornithine lipid + CO2 + succinate => 2-oxoglutarate + an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + O2"}
{"X":53817,"RHEA_ID":53529,"compounds":"1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine => 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-(9Z-octadecenoyl)-1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":53818,"RHEA_ID":60285,"DIRECTION":"LR","MASTER_ID":60284,"metacyc":"RXN-20605","compounds":"N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":53819,"RHEA_ID":59089,"DIRECTION":"LR","MASTER_ID":59088,"metacyc":"RXN-19817","compounds":"D-histidine + S-adenosyl-L-methionine => (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine"}
{"X":53820,"RHEA_ID":55762,"compounds":"an N(2)-[(3R)-3-(acyloxy)acyl]-L-ornithine lipid + holo-[ACP] => a fatty acyl-[ACP] + a lyso-ornithine lipid"}
{"X":53821,"RHEA_ID":59091,"compounds":"D-histidine + S-adenosyl-L-methionine <=> (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine"}
{"X":53822,"RHEA_ID":52436,"DIRECTION":"UN","MASTER_ID":52436,"ec":"2.3.1.265","compounds":"a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + an acyl-CoA = 2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + CoA"}
{"X":53823,"RHEA_ID":52437,"DIRECTION":"LR","MASTER_ID":52436,"metacyc":"RXN-18609","compounds":"a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + an acyl-CoA => 2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + CoA"}
{"X":53824,"RHEA_ID":57981,"DIRECTION":"LR","MASTER_ID":57980,"metacyc":"RXN-14979","compounds":"(20S)-protopanaxatriol + UDP-alpha-D-glucose => (20S)-ginsenoside F1 + H(+) + UDP"}
{"X":53825,"RHEA_ID":56871,"compounds":"(2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + octanoyl-CoA <=> (2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + CoA"}
{"X":53826,"RHEA_ID":52440,"DIRECTION":"UN","MASTER_ID":52440,"ec":"2.4.1.346","compounds":"1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1->2)-D-myo-inositol] + GDP-alpha-D-mannose = a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+)"}
{"X":53827,"RHEA_ID":59097,"DIRECTION":"LR","MASTER_ID":59096,"metacyc":"RXN-20005","compounds":"monoglucosyl-enterobactin + UDP-alpha-D-glucose => diglucosyl-enterobactin + H(+) + UDP"}
{"X":53828,"RHEA_ID":55770,"compounds":"all-trans-retinoyl-1-O-(beta-D-glucuronate) + UDP => all-trans-retinoate + UDP-alpha-D-glucuronate"}
{"X":53829,"RHEA_ID":55771,"compounds":"all-trans-retinoate + UDP-alpha-D-glucuronate <=> all-trans-retinoyl-1-O-(beta-D-glucuronate) + UDP"}
{"X":53830,"RHEA_ID":52444,"DIRECTION":"UN","MASTER_ID":52444,"ec":"2.4.1.346","compounds":"1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1->2)-D-myo-inositol] + GDP-alpha-D-mannose = 2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+)"}
{"X":53831,"RHEA_ID":59101,"DIRECTION":"LR","MASTER_ID":59100,"metacyc":"RXN-20006","compounds":"diglucosyl-enterobactin + UDP-alpha-D-glucose => H(+) + triglucosyl-enterobactin + UDP"}
{"X":53832,"RHEA_ID":55774,"compounds":"a jasmonyl-L-amino acid + AMP + diphosphate + H(+) => a jasmonate + an L-alpha-amino acid + ATP"}
{"X":53833,"RHEA_ID":56879,"compounds":"(R)-N-acetyl-1-phenylethylamine + H2O <=> (R)-1-phenylethylamine + acetate"}
{"X":53834,"RHEA_ID":59104,"compounds":"chenodeoxycholate + dolichyl beta-D-glucosyl phosphate = beta-D-glucosyl-(1->3)-O-chenodeoxycholate + dolichyl phosphate + H(+)"}
{"X":53835,"RHEA_ID":59105,"compounds":"chenodeoxycholate + dolichyl beta-D-glucosyl phosphate => beta-D-glucosyl-(1->3)-O-chenodeoxycholate + dolichyl phosphate + H(+)"}
{"X":53836,"RHEA_ID":55778,"compounds":"4-hydroxy-4-O-(beta-D-glucuronide)-all-trans-retinoate + H(+) + UDP => all-trans-4-hydroxyretinoate + UDP-alpha-D-glucuronate"}
{"X":53837,"RHEA_ID":55779,"compounds":"all-trans-4-hydroxyretinoate + UDP-alpha-D-glucuronate <=> 4-hydroxy-4-O-(beta-D-glucuronide)-all-trans-retinoate + H(+) + UDP"}
{"X":53838,"RHEA_ID":56884,"compounds":"adenosine(32) in tRNA + S-adenosyl-L-methionine = 2'-O-methyladenosine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":53839,"RHEA_ID":53551,"compounds":"prostaglandin J2 <=> Delta(12)-prostaglandin J2"}
{"X":53840,"RHEA_ID":53552,"compounds":"(9S,10R)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(9S,10R)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53841,"RHEA_ID":55783,"compounds":"all-trans-5,6-epoxyretinoate + UDP-alpha-D-glucuronate <=> all-trans-5,6-epoxyretinoyl-1-O-(beta-D-glucuronate) + UDP"}
{"X":53842,"RHEA_ID":52456,"compounds":"testosterone + UDP-alpha-D-glucuronate = H(+) + testosterone 17-O-(beta-D-glucuronate) + UDP"}
{"X":53843,"RHEA_ID":52457,"compounds":"testosterone + UDP-alpha-D-glucuronate => H(+) + testosterone 17-O-(beta-D-glucuronate) + UDP"}
{"X":53844,"RHEA_ID":53556,"compounds":"(9R,10S)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(9R,10S)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53845,"RHEA_ID":55787,"compounds":"all-trans-4-oxoretinoate + UDP-alpha-D-glucuronate <=> all-trans-4-oxoretinoate 1-O-(beta-D-glucuronate) + UDP"}
{"X":53846,"RHEA_ID":52460,"compounds":"17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":53847,"RHEA_ID":53559,"compounds":"(9R,10S)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-(9R,10S)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53848,"RHEA_ID":53560,"compounds":"9,10-epoxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-9,10-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53849,"RHEA_ID":55791,"compounds":"acetone + H(+) + NADH + O2 <=> H2O + hydroxyacetone + NAD(+)"}
{"X":53850,"RHEA_ID":56896,"compounds":"a carboxylate + ATP + H(+) = an acyl-AMP + diphosphate"}
{"X":53851,"RHEA_ID":53563,"compounds":"9,10-epoxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-9,10-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53852,"RHEA_ID":53564,"compounds":"9,10-epoxy-(12Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-9,10-epoxy-(12Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53853,"RHEA_ID":55795,"DIRECTION":"BI","MASTER_ID":55792,"metacyc":"RXN-17575","compounds":"butan-2-one + H(+) + NADH + O2 <=> 1-hydroxy-2-butanone + H2O + NAD(+)"}
{"X":53854,"RHEA_ID":52468,"compounds":"16alpha,17beta-estriol + UDP-alpha-D-glucuronate = 16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":53855,"RHEA_ID":55797,"DIRECTION":"LR","MASTER_ID":55796,"metacyc":"RXN-17570","compounds":"H(+) + NADH + O2 + phenol => H2O + hydroquinone + NAD(+)"}
{"X":53856,"RHEA_ID":53568,"compounds":"12,13-epoxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-12,13-epoxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53857,"RHEA_ID":55799,"compounds":"H(+) + NADH + O2 + phenol <=> H2O + hydroquinone + NAD(+)"}
{"X":53858,"RHEA_ID":52472,"compounds":"16alpha,17beta-estriol + UDP-alpha-D-glucuronate = 16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":53859,"RHEA_ID":54673,"DIRECTION":"LR","MASTER_ID":54672,"metacyc":"RXN-18973","compounds":"(+)-kolavenyl diphosphate + H2O => (+)-kolavelool + diphosphate"}
{"X":53860,"RHEA_ID":53572,"compounds":"8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53861,"RHEA_ID":55803,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + N-acyleicosasphinganine + O2 <=> 2 [Fe(III)-cytochrome b5] + 2 H2O + N-acyleicosasphing-4-enine"}
{"X":53862,"RHEA_ID":52476,"compounds":"estrone + UDP-alpha-D-glucuronate = estrone 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":53863,"RHEA_ID":55805,"compounds":"(R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(2'-(9Z-octadecenoyl)-3'-sn-glycerol) + H2O => (9Z)-octadecenoate + (R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(3'-sn-glycerol) + H(+)"}
{"X":53864,"RHEA_ID":55806,"compounds":"(9Z)-octadecenoate + (R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(3'-sn-glycerol) + H(+) => (R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(2'-(9Z-octadecenoyl)-3'-sn-glycerol) + H2O"}
{"X":53865,"RHEA_ID":55807,"compounds":"(R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(2'-(9Z-octadecenoyl)-3'-sn-glycerol) + H2O <=> (9Z)-octadecenoate + (R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(3'-sn-glycerol) + H(+)"}
{"X":53866,"RHEA_ID":52480,"DIRECTION":"UN","MASTER_ID":52480,"ec":"1.14.14.50","compounds":"16-methoxytabersonine + O2 + reduced [NADPH--hemoprotein reductase] = (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53867,"RHEA_ID":55809,"compounds":"2 [Fe(II)-cytochrome b5] + a dihydroceramide + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a phytoceramide + H2O"}
{"X":53868,"RHEA_ID":55810,"compounds":"2 [Fe(III)-cytochrome b5] + a phytoceramide + H2O => 2 [Fe(II)-cytochrome b5] + a dihydroceramide + 2 H(+) + O2"}
{"X":53869,"RHEA_ID":55811,"compounds":"2 [Fe(II)-cytochrome b5] + a dihydroceramide + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a phytoceramide + H2O"}
{"X":53870,"RHEA_ID":52484,"DIRECTION":"UN","MASTER_ID":52484,"ec":"1.1.99.41","compounds":"(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + A = (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + AH2"}
{"X":53871,"RHEA_ID":53583,"compounds":"14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53872,"RHEA_ID":53584,"compounds":"NAD(+) + resolvin D2 = 7-oxoresolvin D2 + H(+) + NADH"}
{"X":53873,"RHEA_ID":56919,"compounds":"3beta-hydroxy-5alpha-androstan-17-one + NADP(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADPH"}
{"X":53874,"RHEA_ID":52488,"compounds":"O2 + prostaglandin E2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy prostaglandin E2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53875,"RHEA_ID":55817,"DIRECTION":"LR","MASTER_ID":55816,"metacyc":"RXN-18423","compounds":"a bacteriochlorophyllide d + H2O + S-adenosyl-L-methionine => 5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide d + H(+) + L-methionine"}
{"X":53876,"RHEA_ID":53588,"compounds":"NAD(+) + resolvin D2 = 16-oxoresolvin D2 + H(+) + NADH"}
{"X":53877,"RHEA_ID":56923,"compounds":"a medium chain fatty acid + ATP + H(+) <=> a medium-chain fatty acyl-AMP + diphosphate"}
{"X":53878,"RHEA_ID":52492,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53879,"RHEA_ID":55821,"DIRECTION":"LR","MASTER_ID":55820,"metacyc":"RXN-18424","compounds":"a 7(1)-hydroxybacteriochlorophyllide d + H2O + S-adenosyl-L-methionine => 5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide d + H(+) + L-methionine"}
{"X":53880,"RHEA_ID":55822,"compounds":"5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide d + H(+) + L-methionine => a 7(1)-hydroxybacteriochlorophyllide d + H2O + S-adenosyl-L-methionine"}
{"X":53881,"RHEA_ID":55823,"compounds":"a 7(1)-hydroxybacteriochlorophyllide d + H2O + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide d + H(+) + L-methionine"}
{"X":53882,"RHEA_ID":52496,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53883,"RHEA_ID":52497,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53884,"RHEA_ID":53596,"compounds":"1-octadecanoyl-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-sn-glycerol + phosphate"}
{"X":53885,"RHEA_ID":60352,"compounds":"2-heptyl-3-hydroxy-4(1H)-quinolone + O2 = CO + H(+) + N-octanoylanthranilate"}
{"X":53886,"RHEA_ID":52500,"compounds":"(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] = (13R)-hydroxy-(9Z,11E)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53887,"RHEA_ID":53599,"compounds":"1-octadecanoyl-sn-glycero-3-phosphate + H2O <=> 1-octadecanoyl-sn-glycerol + phosphate"}
{"X":53888,"RHEA_ID":53600,"compounds":"1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate"}
{"X":53889,"RHEA_ID":56935,"compounds":"androst-5-en-3beta,17beta-diol + NAD(+) <=> 17beta-hydroxy-androst-5-en-3-one + H(+) + NADH"}
{"X":53890,"RHEA_ID":52504,"compounds":"(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] = 9(R)-hydroxy-(10E,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53891,"RHEA_ID":59177,"DIRECTION":"LR","MASTER_ID":59176,"metacyc":"RXN-19824","compounds":"ADP + L-serine => AMP + H(+) + O-phospho-L-serine"}
{"X":53892,"RHEA_ID":55834,"compounds":"6beta-hydroxycortisone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cortisone + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":53893,"RHEA_ID":55835,"compounds":"cortisone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxycortisone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53894,"RHEA_ID":52508,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53895,"RHEA_ID":52509,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53896,"RHEA_ID":55838,"compounds":"calcitriol 25-O-(beta-D-glucuronide) + H(+) + UDP => calcitriol + UDP-alpha-D-glucuronate"}
{"X":53897,"RHEA_ID":55839,"compounds":"calcitriol + UDP-alpha-D-glucuronate <=> calcitriol 25-O-(beta-D-glucuronide) + H(+) + UDP"}
{"X":53898,"RHEA_ID":55840,"compounds":"calcidiol + UDP-alpha-D-glucuronate = calcidiol 25-O-(beta-D-glucuronide) + H(+) + UDP"}
{"X":53899,"RHEA_ID":59185,"DIRECTION":"LR","MASTER_ID":59184,"metacyc":"RXN-19598","compounds":"2,4-diacetylphloroglucinol + H2O => 2-acetylphloroglucinol + acetate"}
{"X":53900,"RHEA_ID":55842,"compounds":"calcidiol 25-O-(beta-D-glucuronide) + H(+) + UDP => calcidiol + UDP-alpha-D-glucuronate"}
{"X":53901,"RHEA_ID":55843,"compounds":"calcidiol + UDP-alpha-D-glucuronate <=> calcidiol 25-O-(beta-D-glucuronide) + H(+) + UDP"}
{"X":53902,"RHEA_ID":52516,"compounds":"trans-4-hydroxy-L-proline + ubiquinone-10 = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + H(+) + ubiquinol-10"}
{"X":53903,"RHEA_ID":52517,"compounds":"trans-4-hydroxy-L-proline + ubiquinone-10 => (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + H(+) + ubiquinol-10"}
{"X":53904,"RHEA_ID":55846,"compounds":"calcidiol 3-O-(beta-D-glucuronide) + H(+) + UDP => calcidiol + UDP-alpha-D-glucuronate"}
{"X":53905,"RHEA_ID":55847,"compounds":"calcidiol + UDP-alpha-D-glucuronate <=> calcidiol 3-O-(beta-D-glucuronide) + H(+) + UDP"}
{"X":53906,"RHEA_ID":52520,"compounds":"O2 + prostaglandin E1 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy prostaglandin E1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53907,"RHEA_ID":59209,"DIRECTION":"LR","MASTER_ID":59208,"metacyc":"RXN-18542","compounds":"ATP + H(+) + octadecanoate => diphosphate + octadecanoyl-AMP"}
{"X":53908,"RHEA_ID":59210,"compounds":"diphosphate + octadecanoyl-AMP => ATP + H(+) + octadecanoate"}
{"X":53909,"RHEA_ID":55851,"compounds":"[(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA <=> [(2->6)-alpha-D-glucosyl-(1->4)-N,7-O-diacetyl-alpha-D-neuraminosyl](n) + n CoA"}
{"X":53910,"RHEA_ID":52524,"compounds":"O2 + prostaglandin A1 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy prostaglandin A1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53911,"RHEA_ID":52525,"compounds":"O2 + prostaglandin A1 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy prostaglandin A1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53912,"RHEA_ID":55854,"compounds":"[(2->6)-alpha-D-glucosyl-(1->4)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA => [(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA"}
{"X":53913,"RHEA_ID":55855,"compounds":"[(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA <=> [(2->6)-alpha-D-glucosyl-(1->4)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA"}
{"X":53914,"RHEA_ID":52528,"DIRECTION":"UN","MASTER_ID":52528,"ec":"2.6.1.14","compounds":"2-oxoglutarate + L-asparagine = 2-oxosuccinamate + L-glutamate"}
{"X":53915,"RHEA_ID":55857,"compounds":"all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-18-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53916,"RHEA_ID":52530,"compounds":"2-oxosuccinamate + L-glutamate => 2-oxoglutarate + L-asparagine"}
{"X":53917,"RHEA_ID":52531,"compounds":"2-oxoglutarate + L-asparagine <=> 2-oxosuccinamate + L-glutamate"}
{"X":53918,"RHEA_ID":53630,"compounds":"(2S,3R,6S,9S)-(-)-protoillud-7-ene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":53919,"RHEA_ID":52533,"compounds":"adenosine + GTP => AMP + GDP + H(+)"}
{"X":53920,"RHEA_ID":55862,"compounds":"all-trans-5,6-epoxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":53921,"RHEA_ID":55863,"compounds":"all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-5,6-epoxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":53922,"RHEA_ID":55868,"compounds":"(S)-lactate + O2 = H2O2 + pyruvate"}
{"X":53923,"RHEA_ID":52537,"compounds":"adenosine + dGTP => AMP + dGDP + H(+)"}
{"X":53924,"RHEA_ID":55870,"compounds":"H2O2 + pyruvate => (S)-lactate + O2"}
{"X":53925,"RHEA_ID":55871,"compounds":"(S)-lactate + O2 <=> H2O2 + pyruvate"}
{"X":53926,"RHEA_ID":59228,"DIRECTION":"UN","MASTER_ID":59228,"ec":"5.1.3.43","compounds":"6-sulfo-alpha-D-quinovose = 6-sulfo-beta-D-quinovose"}
{"X":53927,"RHEA_ID":52541,"compounds":"cytidine + phosphate => alpha-D-ribose 1-phosphate + cytosine"}
{"X":53928,"RHEA_ID":55874,"DIRECTION":"RL","MASTER_ID":55872,"ecocyc":"RXN0-5375","metacyc":"RXN0-5375","compounds":"2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH => anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+)"}
{"X":53929,"RHEA_ID":56975,"compounds":"(R)-3-hydroxy-2-methylpropanoate + NAD(+) <=> (R)-methylmalonate semialdehyde + H(+) + NADH"}
{"X":53930,"RHEA_ID":59232,"DIRECTION":"UN","MASTER_ID":59232,"ec":"4.2.3.202","compounds":"all-trans-geranylgeranyl diphosphate + H2O = diphosphate + hydropyrenol"}
{"X":53931,"RHEA_ID":52545,"DIRECTION":"LR","MASTER_ID":52544,"metacyc":"RXN-18591","compounds":"D-erythronate + NAD(+) => 2-dehydro-D-erythronate + H(+) + NADH"}
{"X":53932,"RHEA_ID":52546,"compounds":"2-dehydro-D-erythronate + H(+) + NADH => D-erythronate + NAD(+)"}
{"X":53933,"RHEA_ID":55879,"compounds":"apo-[aequorin] + coelenterazine <=> apo-[aequorin]--coelenterazine"}
{"X":53934,"RHEA_ID":52548,"DIRECTION":"UN","MASTER_ID":52548,"ec":"1.1.1.411","compounds":"L-threonate + NAD(+) = 2-dehydro-L-erythronate + H(+) + NADH"}
{"X":53935,"RHEA_ID":52549,"DIRECTION":"LR","MASTER_ID":52548,"metacyc":"RXN-18590","compounds":"L-threonate + NAD(+) => 2-dehydro-L-erythronate + H(+) + NADH"}
{"X":53936,"RHEA_ID":52550,"compounds":"2-dehydro-L-erythronate + H(+) + NADH => L-threonate + NAD(+)"}
{"X":53937,"RHEA_ID":56983,"compounds":"4-hydroxybenzyl alcohol + 2 oxidized [azurin] <=> 4-hydroxybenzaldehyde + 2 H(+) + 2 reduced [azurin]"}
{"X":53938,"RHEA_ID":52552,"DIRECTION":"UN","MASTER_ID":52552,"ec":"2.7.1.217","compounds":"3-dehydro-L-erythronate + ATP = 3-dehydro-4-O-phospho-L-erythronate + ADP + H(+)"}
{"X":53939,"RHEA_ID":61771,"compounds":"rebaudioside A + UDP-alpha-D-glucose <=> H(+) + rebaudioside D + UDP"}
{"X":53940,"RHEA_ID":59241,"compounds":"L-arginine + L-lysine => L-homoarginine + L-ornithine"}
{"X":53941,"RHEA_ID":56987,"compounds":"(2E,6E)-farnesyl diphosphate + H2O <=> (6E)-nerolidol + diphosphate"}
{"X":53942,"RHEA_ID":52556,"DIRECTION":"UN","MASTER_ID":52556,"ec":"2.7.1.217","compounds":"3-dehydro-D-erythronate + ATP = 3-dehydro-4-O-phospho-D-erythronate + ADP + H(+)"}
{"X":53943,"RHEA_ID":55889,"DIRECTION":"LR","MASTER_ID":55888,"metacyc":"RXN-18862","compounds":"[aequorin]--dioxetanone => [excited state blue fluorescent protein] + CO2"}
{"X":53944,"RHEA_ID":58100,"compounds":"1-(15Z-tetracosenoyl)-glycerol + H2O = (15Z)-tetracosenoate + glycerol + H(+)"}
{"X":53945,"RHEA_ID":59247,"compounds":"3''-O-acetyl-ADP-D-ribose + H2O <=> acetate + ADP-D-ribose + H(+)"}
{"X":53946,"RHEA_ID":55892,"DIRECTION":"UN","MASTER_ID":55892,"ec":"1.14.13.240","compounds":"a 2-all-trans-polyprenylphenol + H(+) + NADPH + O2 = a 3-(all-trans-polyprenyl)benzene-1,2-diol + H2O + NADP(+)"}
{"X":53947,"RHEA_ID":52561,"compounds":"2-dehydro-D-erythronate => 3-dehydro-D-erythronate"}
{"X":53948,"RHEA_ID":54766,"compounds":"[LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+) => 5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine"}
{"X":53949,"RHEA_ID":60428,"DIRECTION":"UN","MASTER_ID":60428,"ec":"3.5.1.134","compounds":"(indol-3-yl)acetyl-L-aspartate + H2O = (indol-3-yl)acetate + L-aspartate"}
{"X":53950,"RHEA_ID":59252,"DIRECTION":"UN","MASTER_ID":59252,"ec":"2.8.3.17","compounds":"(E)-3-(indol-3-yl)acryloyl-CoA + (R)-3-(indol-3-yl)lactate = (E)-3-(indol-3-yl)acrylate + (R)-3-(indol-3-yl)lactoyl-CoA"}
{"X":53951,"RHEA_ID":54769,"DIRECTION":"LR","MASTER_ID":54768,"metacyc":"RXN-19045","compounds":"[LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine => [LarE protein]-dehydroalanine + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide"}
{"X":53952,"RHEA_ID":55897,"DIRECTION":"LR","MASTER_ID":55896,"metacyc":"RXN-11104","compounds":"chloride + FADH2 + L-tryptophan + O2 => 5-chloro-L-tryptophan + FAD + 2 H2O"}
{"X":53953,"RHEA_ID":53665,"compounds":"(2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + NH4(+) => H(+) + 2 H2O + pyridinestrone carboxylate"}
{"X":53954,"RHEA_ID":59256,"compounds":"Fe(III)-enterobactin + H2O = Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+)"}
{"X":53955,"RHEA_ID":55901,"DIRECTION":"LR","MASTER_ID":55900,"metacyc":"RXN-19121","compounds":"chloride + FADH2 + L-tryptophan + O2 => 6-chloro-L-tryptophan + FAD + 2 H2O"}
{"X":53956,"RHEA_ID":55902,"compounds":"6-chloro-L-tryptophan + FAD + 2 H2O => chloride + FADH2 + L-tryptophan + O2"}
{"X":53957,"RHEA_ID":59259,"compounds":"Fe(III)-enterobactin + H2O <=> Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+)"}
{"X":53958,"RHEA_ID":59260,"compounds":"Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+) + H2O = Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine"}
{"X":53959,"RHEA_ID":55905,"DIRECTION":"LR","MASTER_ID":55904,"metacyc":"RXN-19122","compounds":"7-chloro-L-tryptophan + chloride + FADH2 + O2 => 6,7-dichloro-L-tryptophan + FAD + 2 H2O"}
{"X":53960,"RHEA_ID":59262,"compounds":"Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine => Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+) + H2O"}
{"X":53961,"RHEA_ID":57007,"compounds":"acetyl-CoA + streptothricin D <=> CoA + H(+) + N(beta)-acetylstreptothricin D"}
{"X":53962,"RHEA_ID":52576,"compounds":"hexanoyl-CoA + NAD(+) = (2E)-hexenoyl-CoA + H(+) + NADH"}
{"X":53963,"RHEA_ID":52577,"compounds":"hexanoyl-CoA + NAD(+) => (2E)-hexenoyl-CoA + H(+) + NADH"}
{"X":53964,"RHEA_ID":55922,"compounds":"(4Z,8Z)-4,8-dimethyl-12-oxotrideca-4,8-dienal + cis-1,4-isoprene(n-3) => [cis-1,4-isoprene](n) + O2"}
{"X":53965,"RHEA_ID":53677,"compounds":"2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 => 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O"}
{"X":53966,"RHEA_ID":59268,"compounds":"A + H2O + N(6)-methyl-L-lysyl-[protein] = AH2 + formaldehyde + L-lysyl-[protein]"}
{"X":53967,"RHEA_ID":52581,"compounds":"ATP + H2O + Pb(2+)(in) => ADP + H(+) + Pb(2+)(out) + phosphate"}
{"X":53968,"RHEA_ID":55926,"compounds":"albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => albendazole + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":53969,"RHEA_ID":52584,"DIRECTION":"UN","MASTER_ID":52584,"ec":"1.1.1.395","compounds":"chenodeoxycholoyl-CoA + NAD(+) = 7alpha-hydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH"}
{"X":53970,"RHEA_ID":53683,"compounds":"2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 <=> 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O"}
{"X":53971,"RHEA_ID":53684,"compounds":"2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O"}
{"X":53972,"RHEA_ID":57019,"compounds":"3,6-dichloro-2-methoxybenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3,6-dichlorosalicylate + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":53973,"RHEA_ID":59276,"compounds":"L-glutamine = D-glutamine"}
{"X":53974,"RHEA_ID":52589,"DIRECTION":"LR","MASTER_ID":52588,"metacyc":"BAIAEUBSP-RXN","compounds":"choloyl-CoA + NAD(+) => 7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH"}
{"X":53975,"RHEA_ID":60467,"compounds":"2',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) <=> 2',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)"}
{"X":53976,"RHEA_ID":60468,"compounds":"3',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) = 3',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)"}
{"X":53977,"RHEA_ID":59280,"compounds":"L-asparagine = D-asparagine"}
{"X":53978,"RHEA_ID":52593,"compounds":"deoxycholoyl-CoA + NAD(+) => 12alpha-hydroxy-3-oxocholan-24-oyl-CoA + H(+) + NADH"}
{"X":53979,"RHEA_ID":55938,"compounds":"all-trans-4-hydroxyretinal + H(+) + NADH => all-trans-4-hydroxyretinol + NAD(+)"}
{"X":53980,"RHEA_ID":59283,"compounds":"L-asparagine <=> D-asparagine"}
{"X":53981,"RHEA_ID":59284,"compounds":"beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = D-glucose + N-octadecanoylsphing-4-enine"}
{"X":53982,"RHEA_ID":52597,"compounds":"lithocholoyl-CoA + NAD(+) => 3-oxocholan-24-oyl-CoA + H(+) + NADH"}
{"X":53983,"RHEA_ID":55942,"compounds":"all-trans-3,4-didehydroretinal + H(+) + NADH => all-trans-3,4-didehydroretinol + NAD(+)"}
{"X":53984,"RHEA_ID":55943,"compounds":"all-trans-3,4-didehydroretinol + NAD(+) <=> all-trans-3,4-didehydroretinal + H(+) + NADH"}
{"X":53985,"RHEA_ID":52600,"compounds":"L-methionine + propanoyl-CoA = CoA + H(+) + N-propanoyl-L-methioninate"}
{"X":53986,"RHEA_ID":55945,"compounds":"2-chloroethanol + 2 [Fe(III)cytochrome c] => 2 [Fe(II)cytochrome c] + chloroacetaldehyde + 2 H(+)"}
{"X":53987,"RHEA_ID":57034,"compounds":"CO2 + formate + methylamine + succinate semialdehyde => (E)-2-((N-methylformamido) methylene)succinate + H(+) + 2 H2O"}
{"X":53988,"RHEA_ID":60480,"compounds":"2 UTP = c-di-UMP + 2 diphosphate"}
{"X":53989,"RHEA_ID":52604,"DIRECTION":"UN","MASTER_ID":52604,"ec":"2.7.1.183","compounds":"3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-seryl-[protein] + ATP = 3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-6-O-phospho-alpha-D-mannosyl)-L-seryl-[protein] + ADP + H(+)"}
{"X":53990,"RHEA_ID":55949,"compounds":"A + D-alanine + H2O => AH2 + NH4(+) + pyruvate"}
{"X":53991,"RHEA_ID":54810,"compounds":"H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate + NADP(+) => H(+) + L-isoleucine-(+)-7-isojasmonate + NADPH + O2"}
{"X":53992,"RHEA_ID":57039,"compounds":"[(1->6)-alpha-D-glucosyl](n) + sucrose <=> (1->3)-alpha-D-glucosyl-[(1->6)-alpha-D-glucosyl]n + D-fructose"}
{"X":53993,"RHEA_ID":52608,"compounds":"2-hydroxybutanoate + NADP(+) = 2-oxobutanoate + H(+) + NADPH"}
{"X":53994,"RHEA_ID":52609,"compounds":"2-hydroxybutanoate + NADP(+) => 2-oxobutanoate + H(+) + NADPH"}
{"X":53995,"RHEA_ID":59298,"compounds":"an N-acyl-(2S)-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical => an N-acylglycine + 2 L-ascorbate + O2"}
{"X":53996,"RHEA_ID":57043,"compounds":"aldehydo-D-apiose <=> D-apiofuranose"}
{"X":53997,"RHEA_ID":52612,"compounds":"3-(methylsulfanyl)propanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = 3-(methylsulfanyl)acryloyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":53998,"RHEA_ID":52613,"DIRECTION":"LR","MASTER_ID":52612,"metacyc":"RXN-12572","compounds":"3-(methylsulfanyl)propanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => 3-(methylsulfanyl)acryloyl-CoA + reduced [electron-transfer flavoprotein]"}
{"X":53999,"RHEA_ID":52614,"compounds":"3-(methylsulfanyl)acryloyl-CoA + reduced [electron-transfer flavoprotein] => 3-(methylsulfanyl)propanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":54000,"RHEA_ID":60508,"compounds":"a guanosine in mRNA + S-adenosyl-L-methionine = an N(7)-methylguanosine in mRNA + S-adenosyl-L-homocysteine"}
{"X":54001,"RHEA_ID":55960,"DIRECTION":"UN","MASTER_ID":55960,"ec":"6.2.1.48","compounds":"4-(trimethylamino)butanoate + ATP + CoA = AMP + diphosphate + gamma-butyrobetainyl-CoA"}
{"X":54002,"RHEA_ID":52617,"compounds":"3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + ATP => 3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-6-O-phospho-alpha-D-mannosyl)-L-threonyl-[protein] + ADP + H(+)"}
{"X":54003,"RHEA_ID":54822,"compounds":"a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":54004,"RHEA_ID":59307,"compounds":"3'-phosphoadenylyl sulfate + firefly L-luciferin <=> adenosine 3',5'-bisphosphate + firefly L-sulfoluciferin + H(+)"}
{"X":54005,"RHEA_ID":55964,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + GTP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + GDP + H(+)"}
{"X":54006,"RHEA_ID":52621,"compounds":"3-methylbutanoyl-CoA => 2,2-dimethylpropanoyl-CoA"}
{"X":54007,"RHEA_ID":54826,"compounds":"alpha-D-glucosyl-(1->3)-D-mannopyranose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2) => H2O + N-{alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-asparaginyl-[protein]"}
{"X":54008,"RHEA_ID":53721,"DIRECTION":"LR","MASTER_ID":53720,"metacyc":"RXN-18660","compounds":"ATP + N-acetyl-D-muramate => ADP + H(+) + N-acetyl-alpha-D-muramate 1-phosphate"}
{"X":54009,"RHEA_ID":55968,"DIRECTION":"UN","MASTER_ID":55968,"ec":"2.1.1.347","compounds":"(+)-kolavelool + S-adenosyl-L-methionine = (+)-O-methylkolavelool + H(+) + S-adenosyl-L-homocysteine"}
{"X":54010,"RHEA_ID":59313,"DIRECTION":"LR","MASTER_ID":59312,"metacyc":"RXN-13740","compounds":"D-galactose + O2 => D-galactono-1,5-lactone + H2O2"}
{"X":54011,"RHEA_ID":55970,"compounds":"(+)-O-methylkolavelool + H(+) + S-adenosyl-L-homocysteine => (+)-kolavelool + S-adenosyl-L-methionine"}
{"X":54012,"RHEA_ID":59315,"compounds":"D-galactose + O2 <=> D-galactono-1,5-lactone + H2O2"}
{"X":54013,"RHEA_ID":55972,"DIRECTION":"UN","MASTER_ID":55972,"ec":"2.3.1.268","compounds":"acetyl-CoA + ethanol = CoA + ethyl acetate"}
{"X":54014,"RHEA_ID":52629,"compounds":"an N-fatty-acyl-L-alpha-amino acid + H2O => a fatty acid + an L-alpha-amino acid"}
{"X":54015,"RHEA_ID":59318,"compounds":"D-cellobiono-1,5-lactone + H2O2 => D-cellobiose + O2"}
{"X":54016,"RHEA_ID":57063,"compounds":"2''-O-acetyl-ADP-D-ribose + H2O <=> acetate + ADP-D-ribose + H(+)"}
{"X":54017,"RHEA_ID":58174,"compounds":"beta-pinacene + diphosphate => all-trans-geranylgeranyl diphosphate"}
{"X":54018,"RHEA_ID":60526,"compounds":"5-methoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine => 5-hydroxyuridine(34) in tRNA + S-adenosyl-L-methionine"}
{"X":54019,"RHEA_ID":57066,"compounds":"D-apionate + H(+) => D-apionolactone + H2O"}
{"X":54020,"RHEA_ID":55979,"compounds":"glutathione + thiosulfate <=> H(+) + S-sulfanylglutathione + sulfite"}
{"X":54021,"RHEA_ID":53734,"compounds":"2-hydroxy-7,8-dihydropteroate + diphosphate => (7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminosalicylate"}
{"X":54022,"RHEA_ID":52637,"compounds":"2-oxoglutarate + a 5-methyl-2'-deoxycytidine in DNA + O2 => a 5-hydroxymethyl-2'-deoxycytidine in DNA + CO2 + succinate"}
{"X":54023,"RHEA_ID":55982,"compounds":"an (R)-2-alkyl-3-oxoalkanoate + 2 CoA + H(+) => 1,2-saturated acyl-CoA + an acyl-CoA + H2O"}
{"X":54024,"RHEA_ID":54843,"compounds":"H(+) + NADPH + O2 + octan-3-one <=> H2O + NADP(+) + pentyl propanoate"}
{"X":54025,"RHEA_ID":60560,"compounds":"L-methionyl-[protein] + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + S-methyl-L-methionyl-[protein]"}
{"X":54026,"RHEA_ID":52641,"compounds":"(2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + octanoyl-CoA => (2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + CoA"}
{"X":54027,"RHEA_ID":54846,"compounds":"ethyl butanoate + H2O + NADP(+) => H(+) + hexan-3-one + NADPH + O2"}
{"X":54028,"RHEA_ID":57075,"compounds":"3-oxo-isoapionate 4-phosphate + H(+) <=> CO2 + L-erythrulose 1-phosphate"}
{"X":54029,"RHEA_ID":53742,"compounds":"[Rab1 protein]-L-tyrosine + AMP + H(+) => [Rab1 protein]-O(4)-(5'-adenylyl)-L-tyrosine + H2O"}
{"X":54030,"RHEA_ID":52644,"DIRECTION":"UN","MASTER_ID":52644,"ec":"3.1.1.104","compounds":"D-xylono-1,4-lactone 5-phosphate + H2O = 5-phospho-D-xylonate + H(+)"}
{"X":54031,"RHEA_ID":59334,"compounds":"1'-hydroxytorulene + AH2 => 1'-hydroxy-gamma-carotene + A"}
{"X":54032,"RHEA_ID":55991,"compounds":"H2O + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] <=> beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein]"}
{"X":54033,"RHEA_ID":52647,"compounds":"D-xylono-1,4-lactone 5-phosphate + H2O <=> 5-phospho-D-xylonate + H(+)"}
{"X":54034,"RHEA_ID":52648,"DIRECTION":"UN","MASTER_ID":52648,"ec":"3.1.1.25","compounds":"H2O + L-arabino-1,4-lactone 5-phosphate = 5-phospho-L-arabinonate + H(+)"}
{"X":54035,"RHEA_ID":60571,"compounds":"N-acetyl-L-tryptophan <=> N-acetyl-D-tryptophan"}
{"X":54036,"RHEA_ID":53749,"compounds":"a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose => a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP"}
{"X":54037,"RHEA_ID":53750,"compounds":"a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose"}
{"X":54038,"RHEA_ID":52651,"compounds":"H2O + L-arabino-1,4-lactone 5-phosphate <=> 5-phospho-L-arabinonate + H(+)"}
{"X":54039,"RHEA_ID":52652,"compounds":"lanosterol + S-adenosyl-L-methionine = 24-methylene-24-dihydrolanosterol + H(+) + S-adenosyl-L-homocysteine"}
{"X":54040,"RHEA_ID":59343,"compounds":"1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene + A <=> 1'-hydroxy-demethylspheroidene + AH2"}
{"X":54041,"RHEA_ID":56000,"DIRECTION":"UN","MASTER_ID":56000,"ec":"3.2.1.207","compounds":"H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] = beta-D-glucose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3)"}
{"X":54042,"RHEA_ID":52655,"compounds":"lanosterol + S-adenosyl-L-methionine <=> 24-methylene-24-dihydrolanosterol + H(+) + S-adenosyl-L-homocysteine"}
{"X":54043,"RHEA_ID":59346,"compounds":"D-maltobiono-1,5-lactone + H2O2 => D-maltose + O2"}
{"X":54044,"RHEA_ID":59347,"compounds":"D-maltose + O2 <=> D-maltobiono-1,5-lactone + H2O2"}
{"X":54045,"RHEA_ID":53758,"compounds":"allodeoxycholate + choloyl-CoA => allodeoxycholoyl-CoA + cholate"}
{"X":54046,"RHEA_ID":52659,"DIRECTION":"BI","MASTER_ID":52656,"metacyc":"1.1.1.211-RXN","compounds":"a long-chain (3S)-hydroxy fatty acyl-CoA + NAD(+) <=> a long-chain 3-oxo-fatty acyl-CoA + H(+) + NADH"}
{"X":54047,"RHEA_ID":52660,"DIRECTION":"UN","MASTER_ID":52660,"ec":"6.2.1.n2","compounds":"an L-alpha-amino acid + ATP + holo-[ACP] = AMP + an L-alpha-aminoacyl-[ACP] + diphosphate"}
{"X":54048,"RHEA_ID":59351,"compounds":"D-maltobiono-1,5-lactone + H2O <=> D-maltobionate + H(+)"}
{"X":54049,"RHEA_ID":56008,"DIRECTION":"UN","MASTER_ID":56008,"ec":"3.2.1.113","compounds":"4 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) = 4 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)"}
{"X":54050,"RHEA_ID":52663,"compounds":"an L-alpha-amino acid + ATP + holo-[ACP] <=> AMP + an L-alpha-aminoacyl-[ACP] + diphosphate"}
{"X":54051,"RHEA_ID":59354,"compounds":"H2O2 + lactobiono-1,5-lactone => beta-lactose + O2"}
{"X":54052,"RHEA_ID":59356,"compounds":"H2O + lactobiono-1,5-lactone = H(+) + lactobionate"}
{"X":54053,"RHEA_ID":52667,"compounds":"a short-chain (3S)-hydroxyacyl-CoA <=> a short-chain (2E)-enoyl-CoA + H2O"}
{"X":54054,"RHEA_ID":52668,"compounds":"[amino group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + NADP(+) + phosphate = [amino group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + H(+) + NADPH"}
{"X":54055,"RHEA_ID":59359,"compounds":"H2O + lactobiono-1,5-lactone <=> H(+) + lactobionate"}
{"X":54056,"RHEA_ID":53770,"compounds":"allocholoyl-CoA + allodeoxycholate => allocholate + allodeoxycholoyl-CoA"}
{"X":54057,"RHEA_ID":56018,"compounds":"beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2) => H2O + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)"}
{"X":54058,"RHEA_ID":56019,"compounds":"H2O + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2)"}
{"X":54059,"RHEA_ID":56020,"compounds":"H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2) = beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2)"}
{"X":54060,"RHEA_ID":59364,"compounds":"1-octadecanoyl-2-(9,10-epoxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O = 1-octadecanoyl-sn-glycero-3-phosphoserine + 9,10-epoxyoctadecanoate + H(+)"}
{"X":54061,"RHEA_ID":59365,"compounds":"1-octadecanoyl-2-(9,10-epoxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O => 1-octadecanoyl-sn-glycero-3-phosphoserine + 9,10-epoxyoctadecanoate + H(+)"}
{"X":54062,"RHEA_ID":56023,"compounds":"H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2)"}
{"X":54063,"RHEA_ID":57111,"compounds":"1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine"}
{"X":54064,"RHEA_ID":52680,"compounds":"acetyl-CoA + L-alpha-phenylglycine = CoA + H(+) + N-acetyl-L-alpha-phenylglycine"}
{"X":54065,"RHEA_ID":53781,"compounds":"beta-muricholate + lithocholoyl-CoA => beta-muricholoyl-CoA + lithocholate"}
{"X":54066,"RHEA_ID":56028,"DIRECTION":"UN","MASTER_ID":56028,"ec":"3.2.1.113","compounds":"3 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) = 3 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)"}
{"X":54067,"RHEA_ID":52683,"compounds":"acetyl-CoA + L-alpha-phenylglycine <=> CoA + H(+) + N-acetyl-L-alpha-phenylglycine"}
{"X":54068,"RHEA_ID":59373,"compounds":"1-hexadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O => 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + 10-hydroxyoctadecanoate + H(+)"}
{"X":54069,"RHEA_ID":53785,"compounds":"beta-muricholate + deoxycholoyl-CoA => beta-muricholoyl-CoA + deoxycholate"}
{"X":54070,"RHEA_ID":52686,"compounds":"H(+) + NADH + pyridoxal => NAD(+) + pyridoxine"}
{"X":54071,"RHEA_ID":52687,"compounds":"NAD(+) + pyridoxine <=> H(+) + NADH + pyridoxal"}
{"X":54072,"RHEA_ID":59377,"compounds":"4-amino-4-deoxychorismate => 4-amino-4-deoxyprephenate"}
{"X":54073,"RHEA_ID":56035,"compounds":"H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1)"}
{"X":54074,"RHEA_ID":52690,"compounds":"3-phenylpyruvate + H(+) + NADH => 3-phenyllactate + NAD(+)"}
{"X":54075,"RHEA_ID":52691,"compounds":"3-phenyllactate + NAD(+) <=> 3-phenylpyruvate + H(+) + NADH"}
{"X":54076,"RHEA_ID":52692,"compounds":"3-phenyllactate + NADP(+) = 3-phenylpyruvate + H(+) + NADPH"}
{"X":54077,"RHEA_ID":59382,"compounds":"3-(4-aminophenyl)pyruvate + CO2 + H(+) + NADH => 4-amino-4-deoxyprephenate + NAD(+)"}
{"X":54078,"RHEA_ID":56040,"compounds":"H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3) = beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)"}
{"X":54079,"RHEA_ID":52695,"compounds":"3-phenyllactate + NADP(+) <=> 3-phenylpyruvate + H(+) + NADPH"}
{"X":54080,"RHEA_ID":56042,"compounds":"beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3)"}
{"X":54081,"RHEA_ID":56043,"compounds":"H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)"}
{"X":54082,"RHEA_ID":57131,"compounds":"H2O + 2 oxidized [azurin] + tyramine <=> (4-hydroxyphenyl)acetaldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin]"}
{"X":54083,"RHEA_ID":59388,"compounds":"a fatty acid ester + H2O = a fatty acid + an aliphatic alcohol + H(+)"}
{"X":54084,"RHEA_ID":59389,"compounds":"a fatty acid ester + H2O => a fatty acid + an aliphatic alcohol + H(+)"}
{"X":54085,"RHEA_ID":53801,"compounds":"lithocholoyl-CoA + ursodeoxycholate => lithocholate + ursodeoxycholoyl-CoA"}
{"X":54086,"RHEA_ID":57135,"compounds":"L-ascorbate + O2 + tyramine <=> (2R)-1-(4-hydroxyphenyl)-2-aminoethanol + H2O + L-dehydroascorbate"}
{"X":54087,"RHEA_ID":52707,"compounds":"H2O + UMP <=> D-ribose 5-phosphate + uracil"}
{"X":54088,"RHEA_ID":59393,"compounds":"acetyl-CoA + L-seryl-[protein] => CoA + O-acetyl-L-seryl-[protein]"}
{"X":54089,"RHEA_ID":53805,"compounds":"allodeoxycholoyl-CoA + ursodeoxycholate => allodeoxycholate + ursodeoxycholoyl-CoA"}
{"X":54090,"RHEA_ID":53806,"compounds":"allodeoxycholate + ursodeoxycholoyl-CoA => allodeoxycholoyl-CoA + ursodeoxycholate"}
{"X":54091,"RHEA_ID":52711,"compounds":"GMP + H2O <=> D-ribose 5-phosphate + guanine"}
{"X":54092,"RHEA_ID":57141,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine => 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine"}
{"X":54093,"RHEA_ID":52713,"compounds":"dTMP + H2O => 2-deoxy-D-ribose 5-phosphate + thymine"}
{"X":54094,"RHEA_ID":60661,"compounds":"1,4-benzoquinone + H(+) + NADH => hydroquinone + NAD(+)"}
{"X":54095,"RHEA_ID":52715,"compounds":"dTMP + H2O <=> 2-deoxy-D-ribose 5-phosphate + thymine"}
{"X":54096,"RHEA_ID":52716,"DIRECTION":"UN","MASTER_ID":52716,"ec":"1.2.1.84","compounds":"a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP(+)"}
{"X":54097,"RHEA_ID":52717,"DIRECTION":"LR","MASTER_ID":52716,"metacyc":"RXN-9344","compounds":"a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH => a long-chain primary fatty alcohol + CoA + 2 NADP(+)"}
{"X":54098,"RHEA_ID":53814,"compounds":"(25R)-26-hydroxycholestanol + H2O + 2 oxidized [adrenodoxin] => cholestanol + 2 H(+) + O2 + 2 reduced [adrenodoxin]"}
{"X":54099,"RHEA_ID":56061,"DIRECTION":"LR","MASTER_ID":56060,"metacyc":"RXN-19211","compounds":"H(+) + hexadecanoate + hnu => CO2 + pentadecane"}
{"X":54100,"RHEA_ID":59405,"compounds":"L-homoserine => D-homoserine"}
{"X":54101,"RHEA_ID":52721,"DIRECTION":"LR","MASTER_ID":52720,"metacyc":"RXN-18457","compounds":"5-methyluridine(54) in tRNA + [TtuB sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + ATP + H2O => 5-methyl-2-thiouridine(54) in tRNA + [TtuB sulfur-carrier protein]-C-terminal Gly-Gly + AMP + diphosphate + 2 H(+)"}
{"X":54102,"RHEA_ID":57151,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)"}
{"X":54103,"RHEA_ID":52723,"compounds":"5-methyluridine(54) in tRNA + [TtuB sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + ATP + H2O <=> 5-methyl-2-thiouridine(54) in tRNA + [TtuB sulfur-carrier protein]-C-terminal Gly-Gly + AMP + diphosphate + 2 H(+)"}
{"X":54104,"RHEA_ID":52724,"DIRECTION":"UN","MASTER_ID":52724,"ec":"2.8.2.38","compounds":"3'-phosphoadenylyl sulfate + an aliphatic desulfo-glucosinolate = adenosine 3',5'-bisphosphate + an omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + H(+)"}
{"X":54105,"RHEA_ID":52725,"DIRECTION":"LR","MASTER_ID":52724,"metacyc":"RXN-18179","compounds":"3'-phosphoadenylyl sulfate + an aliphatic desulfo-glucosinolate => adenosine 3',5'-bisphosphate + an omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + H(+)"}
{"X":54106,"RHEA_ID":52727,"compounds":"3'-phosphoadenylyl sulfate + an aliphatic desulfo-glucosinolate <=> adenosine 3',5'-bisphosphate + an omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + H(+)"}
{"X":54107,"RHEA_ID":52728,"DIRECTION":"UN","MASTER_ID":52728,"ec":"2.8.2.39","compounds":"3'-phosphoadenylyl sulfate + a 12-hydroxyjasmonate = a 12-sulfojasmonate + adenosine 3',5'-bisphosphate + H(+)"}
{"X":54108,"RHEA_ID":53825,"compounds":"NAD(+) + taurochenodeoxycholate => 7-oxo-taurolithocholate + H(+) + NADH"}
{"X":54109,"RHEA_ID":53826,"compounds":"7-oxo-taurolithocholate + H(+) + NADH => NAD(+) + taurochenodeoxycholate"}
{"X":54110,"RHEA_ID":52731,"compounds":"3'-phosphoadenylyl sulfate + a 12-hydroxyjasmonate <=> a 12-sulfojasmonate + adenosine 3',5'-bisphosphate + H(+)"}
{"X":54111,"RHEA_ID":52732,"DIRECTION":"UN","MASTER_ID":52732,"ec":"2.8.2.39","compounds":"3'-phosphoadenylyl sulfate + an 11-hydroxyjasmonate = adenosine 3',5'-bisphosphate + an 11-sulfojasmonate + H(+)"}
{"X":54112,"RHEA_ID":56074,"compounds":"a 2-acylphloroglucinol 1-O-beta-D-glucoside + UDP => a 2-acylphloroglucinol + UDP-alpha-D-glucose"}
{"X":54113,"RHEA_ID":59418,"compounds":"H2O2 + indole-3-acetaldehyde + NH4(+) => H2O + O2 + tryptamine"}
{"X":54114,"RHEA_ID":52735,"compounds":"3'-phosphoadenylyl sulfate + an 11-hydroxyjasmonate <=> adenosine 3',5'-bisphosphate + an 11-sulfojasmonate + H(+)"}
{"X":54115,"RHEA_ID":52736,"DIRECTION":"UN","MASTER_ID":52736,"ec":"2.8.2.24","compounds":"3'-phosphoadenylyl sulfate + indolylmethyl-desulfoglucosinolate = adenosine 3',5'-bisphosphate + glucobrassicin + H(+)"}
{"X":54116,"RHEA_ID":59422,"compounds":"formaldehyde + H2O2 + NH4(+) => H2O + methylamine + O2"}
{"X":54117,"RHEA_ID":56079,"compounds":"an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose <=> an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)"}
{"X":54118,"RHEA_ID":56080,"compounds":"[Rab1 protein]-L-serine + CDP-choline = [Rab1 protein]-O-phosphocholine-L-serine + CMP + H(+)"}
{"X":54119,"RHEA_ID":52740,"compounds":"glyphosate + H2O + O2 = aminomethylphosphonate + glyoxylate + H(+) + H2O2"}
{"X":54120,"RHEA_ID":59426,"compounds":"benzaldehyde + H2O2 + NH4(+) => benzylamine + H2O + O2"}
{"X":54121,"RHEA_ID":59427,"compounds":"benzylamine + H2O + O2 <=> benzaldehyde + H2O2 + NH4(+)"}
{"X":54122,"RHEA_ID":52743,"compounds":"glyphosate + H2O + O2 <=> aminomethylphosphonate + glyoxylate + H(+) + H2O2"}
{"X":54123,"RHEA_ID":52744,"compounds":"cyclobis-(1->3)-alpha-isomaltosyl + H2O = alpha-isomaltosyl-(1->3)-isomaltose"}
{"X":54124,"RHEA_ID":53845,"compounds":"glycochenodeoxycholate + NAD(+) => 7-oxo-glycolithocholate + H(+) + NADH"}
{"X":54125,"RHEA_ID":57175,"compounds":"(S)-2-hydroxyglutarate + NAD(+) <=> 2-oxoglutarate + H(+) + NADH"}
{"X":54126,"RHEA_ID":56088,"compounds":"CMP-N-acetyl-beta-neuraminate + globoside MSGG = CMP + globoside DSGG + H(+)"}
{"X":54127,"RHEA_ID":56089,"DIRECTION":"LR","MASTER_ID":56088,"metacyc":"2.4.1.155-RXN","compounds":"CMP-N-acetyl-beta-neuraminate + globoside MSGG => CMP + globoside DSGG + H(+)"}
{"X":54128,"RHEA_ID":59442,"compounds":"(S)-isodihydrodehydrodiconiferyl alcohol + NADP(+) => (-)-dehydrodiconiferyl alcohol + H(+) + NADPH"}
{"X":54129,"RHEA_ID":59443,"compounds":"(-)-dehydrodiconiferyl alcohol + H(+) + NADPH <=> (S)-isodihydrodehydrodiconiferyl alcohol + NADP(+)"}
{"X":54130,"RHEA_ID":56092,"compounds":"bilirubin IXalpha + H(+) + oxidized coenzyme F420-(gamma-Glu)(n) = biliverdin IXalpha + reduced coenzyme F420-(gamma-Glu)(n)"}
{"X":54131,"RHEA_ID":52752,"DIRECTION":"UN","MASTER_ID":52752,"ec":"3.2.1.205","compounds":"H2O + isomaltose = beta-D-glucose + D-glucose"}
{"X":54132,"RHEA_ID":53853,"compounds":"glycocholate + NAD(+) => 7-oxo-glycodeoxycholate + H(+) + NADH"}
{"X":54133,"RHEA_ID":59447,"compounds":"1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene + A <=> 1,1'-dihydroxy-3,4-didehydro-1,2-dihydrolycopene + AH2"}
{"X":54134,"RHEA_ID":56096,"compounds":"[protein]-C-terminal Gly-Gly + ATP + H(+) = [protein]-C-terminal Gly-Gly-AMP + diphosphate"}
{"X":54135,"RHEA_ID":52756,"DIRECTION":"UN","MASTER_ID":52756,"ec":"3.4.19.16","compounds":"an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O = an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-cysteinylglycine + L-glutamate"}
{"X":54136,"RHEA_ID":56098,"compounds":"[protein]-C-terminal Gly-Gly-AMP + diphosphate => [protein]-C-terminal Gly-Gly + ATP + H(+)"}
{"X":54137,"RHEA_ID":52758,"compounds":"an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-cysteinylglycine + L-glutamate => an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O"}
{"X":54138,"RHEA_ID":56100,"DIRECTION":"UN","MASTER_ID":56100,"ec":"2.7.7.100","compounds":"[small archaeal modifier protein]-C-terminal Gly-Gly + ATP + H(+) = [small archaeal modifier protein]-C-terminal Gly-Gly-AMP + diphosphate"}
{"X":54139,"RHEA_ID":56101,"DIRECTION":"LR","MASTER_ID":56100,"metacyc":"RXN-18689","compounds":"[small archaeal modifier protein]-C-terminal Gly-Gly + ATP + H(+) => [small archaeal modifier protein]-C-terminal Gly-Gly-AMP + diphosphate"}
{"X":54140,"RHEA_ID":53861,"compounds":"7beta-hydroxy-3,12-dioxo-5beta-cholan-24-oate + NADP(+) => dehydrocholate + H(+) + NADPH"}
{"X":54141,"RHEA_ID":59455,"compounds":"a long-chain primary fatty alcohol + NADP(+) <=> a long-chain fatty aldehyde + H(+) + NADPH"}
{"X":54142,"RHEA_ID":56104,"compounds":"2 AH2 + all-trans-4,4'-diaponeurosporene + 2 O2 = 4,4'-diaponeurosporenal + 2 A + 3 H2O"}
{"X":54143,"RHEA_ID":56105,"DIRECTION":"LR","MASTER_ID":56104,"metacyc":"RXN-9306","compounds":"2 AH2 + all-trans-4,4'-diaponeurosporene + 2 O2 => 4,4'-diaponeurosporenal + 2 A + 3 H2O"}
{"X":54144,"RHEA_ID":53865,"compounds":"3alpha,7beta-dihydroxy-12-oxo-5beta-cholan-24-oate + NADP(+) => 7,12-dioxo-lithocholate + H(+) + NADPH"}
{"X":54145,"RHEA_ID":59459,"compounds":"NADP(+) + tetradecan-1-ol <=> H(+) + NADPH + tetradecanal"}
{"X":54146,"RHEA_ID":56108,"DIRECTION":"UN","MASTER_ID":56108,"ec":"1.14.14.90","compounds":"genistein + O2 + reduced [NADPH--hemoprotein reductase] = 2'-hydroxygenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54147,"RHEA_ID":56109,"DIRECTION":"LR","MASTER_ID":56108,"metacyc":"RXN-7141","compounds":"genistein + O2 + reduced [NADPH--hemoprotein reductase] => 2'-hydroxygenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54148,"RHEA_ID":54971,"compounds":"hexadecanoyl phosphate + sn-glycerol 3-phosphate <=> 1-hexadecanoyl-sn-glycero-3-phosphate + phosphate"}
{"X":54149,"RHEA_ID":57199,"compounds":"H2O + S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein] <=> glycolate + H(+) + L-cysteinyl-[protein]"}
{"X":54150,"RHEA_ID":56112,"compounds":"2-all-trans-nonaprenylphenol + H(+) + NADPH + O2 = 3-(all-trans-nonaprenyl)benzene-1,2-diol + H2O + NADP(+)"}
{"X":54151,"RHEA_ID":56113,"DIRECTION":"LR","MASTER_ID":56112,"metacyc":"RXN-9239","compounds":"2-all-trans-nonaprenylphenol + H(+) + NADPH + O2 => 3-(all-trans-nonaprenyl)benzene-1,2-diol + H2O + NADP(+)"}
{"X":54152,"RHEA_ID":59466,"compounds":"H(+) + NADPH + octadecanal => NADP(+) + octadecan-1-ol"}
{"X":54153,"RHEA_ID":53874,"compounds":"CDP-D-ribose + diphosphate => CTP + D-ribose 5-phosphate + H(+)"}
{"X":54154,"RHEA_ID":56116,"compounds":"2-all-trans-decaprenylphenol + H(+) + NADPH + O2 = 3-(all-trans-decaprenyl)benzene-1,2-diol + H2O + NADP(+)"}
{"X":54155,"RHEA_ID":52776,"DIRECTION":"UN","MASTER_ID":52776,"ec":"1.14.19.52","compounds":"2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = camalexin + CO2 + 2 H(+) + 4 H2O + hydrogen cyanide + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":54156,"RHEA_ID":56118,"compounds":"3-(all-trans-decaprenyl)benzene-1,2-diol + H2O + NADP(+) => 2-all-trans-decaprenylphenol + H(+) + NADPH + O2"}
{"X":54157,"RHEA_ID":56119,"compounds":"2-all-trans-decaprenylphenol + H(+) + NADPH + O2 <=> 3-(all-trans-decaprenyl)benzene-1,2-diol + H2O + NADP(+)"}
{"X":54158,"RHEA_ID":56120,"compounds":"2-all-trans-heptaprenylphenol + H(+) + NADPH + O2 = 3-(all-trans-heptaprenyl)benzene-1,2-diol + H2O + NADP(+)"}
{"X":54159,"RHEA_ID":52780,"compounds":"H2O + S-(hercyn-2-yl)-L-cysteine S-oxide = 2-sulfenohercynine + NH4(+) + pyruvate"}
{"X":54160,"RHEA_ID":54983,"compounds":"alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-di-trans,octa-cis-undecaprenol + 2 GDP-alpha-D-mannose <=> [alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n+1)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenol + 2 GDP + 2 H(+)"}
{"X":54161,"RHEA_ID":53882,"compounds":"ADP + alpha,alpha-trehalose 6-phosphate + H(+) => ADP-alpha-D-glucose + D-glucose 6-phosphate"}
{"X":54162,"RHEA_ID":56124,"DIRECTION":"UN","MASTER_ID":56124,"ec":"2.5.1.149","compounds":"A + all-trans-lycopene + dimethylallyl diphosphate + H2O = AH2 + diphosphate + nonaflavuxanthin"}
{"X":54163,"RHEA_ID":56125,"DIRECTION":"LR","MASTER_ID":56124,"metacyc":"RXN18HP-8","compounds":"A + all-trans-lycopene + dimethylallyl diphosphate + H2O => AH2 + diphosphate + nonaflavuxanthin"}
{"X":54164,"RHEA_ID":59478,"compounds":"2 A + 2 AMP + 2 diphosphate + H(+) + N-benzoyl-L-phenylalaninol => 2 AH2 + 2 ATP + benzoate + L-phenylalanine"}
{"X":54165,"RHEA_ID":56127,"compounds":"A + all-trans-lycopene + dimethylallyl diphosphate + H2O <=> AH2 + diphosphate + nonaflavuxanthin"}
{"X":54166,"RHEA_ID":56128,"DIRECTION":"UN","MASTER_ID":56128,"ec":"2.5.1.149","compounds":"A + dimethylallyl diphosphate + H2O + nonaflavuxanthin = AH2 + diphosphate + flavuxanthin"}
{"X":54167,"RHEA_ID":56129,"DIRECTION":"LR","MASTER_ID":56128,"metacyc":"RXN18HP-9","compounds":"A + dimethylallyl diphosphate + H2O + nonaflavuxanthin => AH2 + diphosphate + flavuxanthin"}
{"X":54168,"RHEA_ID":59486,"compounds":"2 [Fe(II)cytochrome c] + arsenate + 3 H(+) => 2 [Fe(III)cytochrome c] + arsenite + H2O"}
{"X":54169,"RHEA_ID":56132,"DIRECTION":"UN","MASTER_ID":56132,"ec":"4.1.99.14","compounds":"(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine in DNA = a thymidine dimer in DNA"}
{"X":54170,"RHEA_ID":56133,"DIRECTION":"LR","MASTER_ID":56132,"metacyc":"RXN-11051","compounds":"(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine in DNA => a thymidine dimer in DNA"}
{"X":54171,"RHEA_ID":52793,"DIRECTION":"LR","MASTER_ID":52792,"metacyc":"RXN-7739","compounds":"chlorophyllide a + 2 H(+) => Mg(2+) + pheophorbide a"}
{"X":54172,"RHEA_ID":60741,"compounds":"(S)-(-)-citronellal + H2O + NADP(+) => (S)-(-)-citronellate + 2 H(+) + NADPH"}
{"X":54173,"RHEA_ID":56136,"DIRECTION":"UN","MASTER_ID":56136,"ec":"1.11.1.7","compounds":"2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O"}
{"X":54174,"RHEA_ID":56137,"DIRECTION":"LR","MASTER_ID":56136,"ecocyc":"PEROXID-RXN","metacyc":"PEROXID-RXN","compounds":"2 a phenolic donor + H2O2 => 2 a phenolic radical donor + 2 H2O"}
{"X":54175,"RHEA_ID":57226,"compounds":"N(2)-(1-hydroxy-2-oxoethyl)-GTP => glyoxal + GTP"}
{"X":54176,"RHEA_ID":53898,"compounds":"an N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+) => an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate"}
{"X":54177,"RHEA_ID":56140,"DIRECTION":"UN","MASTER_ID":56140,"ec":"3.13.1.8","compounds":"H2O + S-adenosyl-L-methionine = adenosine + H(+) + L-methionine"}
{"X":54178,"RHEA_ID":56141,"DIRECTION":"LR","MASTER_ID":56140,"metacyc":"RXN-19155","compounds":"H2O + S-adenosyl-L-methionine => adenosine + H(+) + L-methionine"}
{"X":54179,"RHEA_ID":57230,"compounds":"N(2)-(1-hydroxy-2-oxoethyl)-GDP => GDP + glyoxal"}
{"X":54180,"RHEA_ID":59499,"compounds":"(20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + O2 + reduced [NADPH--hemoprotein reductase] <=> (20S)-ginsenoside C-K + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54181,"RHEA_ID":56144,"DIRECTION":"UN","MASTER_ID":56144,"ec":"1.7.5.1","compounds":"a quinol + nitrate = a quinone + H2O + nitrite"}
{"X":54182,"RHEA_ID":59501,"compounds":"5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H(+) + phosphate"}
{"X":54183,"RHEA_ID":57234,"compounds":"N(2)-(1-hydroxy-2-oxopropyl)-GDP => GDP + methylglyoxal"}
{"X":54184,"RHEA_ID":56148,"compounds":"hexadecanoyl-CoA + sn-glycerol 3-phosphocholine = CoA + hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":54185,"RHEA_ID":56149,"compounds":"hexadecanoyl-CoA + sn-glycerol 3-phosphocholine => CoA + hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":54186,"RHEA_ID":52809,"DIRECTION":"LR","MASTER_ID":52808,"metacyc":"RXN-18779","compounds":"adenosine in U6 snRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine in U6 snRNA + S-adenosyl-L-homocysteine"}
{"X":54187,"RHEA_ID":56151,"compounds":"hexadecanoyl-CoA + sn-glycerol 3-phosphocholine <=> CoA + hexadecanoyl-sn-glycero-3-phosphocholine"}
{"X":54188,"RHEA_ID":59508,"compounds":"fumarate + L-cysteinyl-[protein] = S-(2-succinyl)-L-cysteinyl-[protein]"}
{"X":54189,"RHEA_ID":62056,"compounds":"alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose = alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+)"}
{"X":54190,"RHEA_ID":57242,"compounds":"N(2)-(1-hydroxy-2-oxoethyl)-GMP => glyoxal + GMP"}
{"X":54191,"RHEA_ID":56155,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphocholine <=> (9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":54192,"RHEA_ID":52815,"compounds":"1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O <=> (9Z,12Z)-octadecadienoate + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H(+)"}
{"X":54193,"RHEA_ID":55018,"compounds":"7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+) => H(+) + menthone + NADPH + O2"}
{"X":54194,"RHEA_ID":52817,"compounds":"an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine => an N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP"}
{"X":54195,"RHEA_ID":56159,"compounds":"(12R)-hydroxy-(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine <=> (12R-hydroxy-9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":54196,"RHEA_ID":52819,"compounds":"an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine <=> an N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP"}
{"X":54197,"RHEA_ID":56161,"DIRECTION":"LR","MASTER_ID":56160,"metacyc":"RXN-16599","compounds":"an archaeal dolichyl alpha-D-glucosyl phosphate + UDP-alpha-D-glucuronate => an archaeal dolichyl beta-D-glucuronosyl-(1->4)-alpha-D-glucosyl phosphate + H(+) + UDP"}
{"X":54198,"RHEA_ID":52821,"compounds":"L-serine + succinyl-CoA => CoA + O-succinyl-L-serine"}
{"X":54199,"RHEA_ID":59519,"compounds":"acetylsalicylate + L-lysyl-[protein] <=> H(+) + N(6)-acetyl-L-lysyl-[protein] + salicylate"}
{"X":54200,"RHEA_ID":52823,"compounds":"L-serine + succinyl-CoA <=> CoA + O-succinyl-L-serine"}
{"X":54201,"RHEA_ID":56165,"compounds":"(9Z,12Z,15Z)-octadecatrienoyl-CoA + sn-glycerol 3-phosphocholine => (9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":54202,"RHEA_ID":57254,"compounds":"glycolate + GTP + H(+) => H2O + N(2)-(1-hydroxy-2-oxoethyl)-GTP"}
{"X":54203,"RHEA_ID":59523,"compounds":"ATP + butanoyl-CoA + hydrogencarbonate <=> (2S)-ethylmalonyl-CoA + ADP + H(+) + phosphate"}
{"X":54204,"RHEA_ID":56168,"compounds":"(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":54205,"RHEA_ID":59524,"compounds":"9S,10-epoxy-(10,12Z)-octadecadienoate + H(+) + L-aspartyl-[protein] = 9-O-10-oxo-(12Z)-octadecenoate L-aspartatyl ester-[protein]"}
{"X":54206,"RHEA_ID":57258,"compounds":"GTP + H(+) + lactate => H2O + N(2)-(1-hydroxy-2-oxopropyl)-GTP"}
{"X":54207,"RHEA_ID":56171,"compounds":"(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":54208,"RHEA_ID":56172,"compounds":"FMN + O2 = 8-demethyl-8-formylriboflavin 5'-phosphate + H2O"}
{"X":54209,"RHEA_ID":58376,"compounds":"decan-1-ol + NADP(+) = decanal + H(+) + NADPH"}
{"X":54210,"RHEA_ID":57262,"compounds":"GDP + H(+) + lactate => H2O + N(2)-(1-hydroxy-2-oxopropyl)-GDP"}
{"X":54211,"RHEA_ID":56175,"compounds":"FMN + O2 <=> 8-demethyl-8-formylriboflavin 5'-phosphate + H2O"}
{"X":54212,"RHEA_ID":52835,"compounds":"1-hydroxylimonen-2-one + H(+) + NADPH + O2 <=> 7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)"}
{"X":54213,"RHEA_ID":62080,"compounds":"D-glucose 6-sulfate + NADP(+) = 6-sulfo-D-glucono-1,5-lactone + H(+) + NADPH"}
{"X":54214,"RHEA_ID":57266,"compounds":"GDP + glycolate + H(+) => H2O + N(2)-(1-hydroxy-2-oxoethyl)-GDP"}
{"X":54215,"RHEA_ID":59535,"compounds":"(S)-reticuline + S-adenosyl-L-methionine <=> (S)-codamine + H(+) + S-adenosyl-L-homocysteine"}
{"X":54216,"RHEA_ID":52839,"compounds":"H(+) + indole + NADH + O2 <=> H2O + indoxyl + NAD(+)"}
{"X":54217,"RHEA_ID":62084,"DIRECTION":"UN","MASTER_ID":62084,"ec":"2.7.1.147","compounds":"ADP + D-glucosamine = AMP + D-glucosamine 6-phosphate + H(+)"}
{"X":54218,"RHEA_ID":57270,"compounds":"GMP + H(+) + lactate => H2O + N(2)-(1-hydroxy-2-oxopropyl)-GMP"}
{"X":54219,"RHEA_ID":56183,"compounds":"8-carboxy-8-demethylriboflavin 5'-phosphate + 2 A + H2O + L-glutamate <=> 2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 2 AH2 + CO2"}
{"X":54220,"RHEA_ID":52843,"compounds":"4-hydroxy-3-methoxybenzoate + UDP-alpha-D-glucose <=> 1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + UDP"}
{"X":54221,"RHEA_ID":52844,"DIRECTION":"UN","MASTER_ID":52844,"ec":"2.4.1.136","compounds":"3,4-dihydroxybenzoate + UDP-alpha-D-glucose = 1-O-(3,4-dihydroxy-benzoyl)-beta-D-glucose + UDP"}
{"X":54222,"RHEA_ID":57274,"compounds":"an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA => a 2'-deoxyguanosine in DNA + methylglyoxal"}
{"X":54223,"RHEA_ID":52847,"compounds":"3,4-dihydroxybenzoate + UDP-alpha-D-glucose <=> 1-O-(3,4-dihydroxy-benzoyl)-beta-D-glucose + UDP"}
{"X":54224,"RHEA_ID":59545,"compounds":"N,N'-diacetylchitobiose + O2 => H2O2 + N,N'-diacetylchitobiono-1,5-lactone"}
{"X":54225,"RHEA_ID":57278,"compounds":"an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA => a 2'-deoxyguanosine in DNA + glyoxal"}
{"X":54226,"RHEA_ID":52851,"compounds":"5-hydroxyuridine(34) in tRNA + carboxy-S-adenosyl-L-methionine <=> 5-carboxymethoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":54227,"RHEA_ID":59549,"compounds":"N,N',N''-triacetylchitotriose + O2 => H2O2 + N,N',N''-triacetylchitotriono-1,5-lactone"}
{"X":54228,"RHEA_ID":57282,"compounds":"an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA => a guanosine in RNA + glyoxal"}
{"X":54229,"RHEA_ID":53954,"compounds":"4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + ADP + H(+) + phosphate => 4-aminobutanoyl-[BtrI ACP] + ATP + L-glutamate"}
{"X":54230,"RHEA_ID":58399,"compounds":"4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + 5 H(+) + O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + NH4(+) + 4 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":54231,"RHEA_ID":52856,"DIRECTION":"UN","MASTER_ID":52856,"ec":"1.5.8.4","compounds":"(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n + H(+) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + reduced [electron-transfer flavoprotein] + sarcosine"}
{"X":54232,"RHEA_ID":52857,"DIRECTION":"LR","MASTER_ID":52856,"metacyc":"DIMETHYLGLYCINE-DEHYDROGENASE-RXN","compounds":"(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n + H(+) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] => (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + reduced [electron-transfer flavoprotein] + sarcosine"}
{"X":54233,"RHEA_ID":52858,"compounds":"(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + reduced [electron-transfer flavoprotein] + sarcosine => (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n + H(+) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein]"}
{"X":54234,"RHEA_ID":56200,"compounds":"3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-alpha-D-galactose = H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP"}
{"X":54235,"RHEA_ID":56201,"DIRECTION":"LR","MASTER_ID":56200,"metacyc":"2.4.1.122-RXN","compounds":"3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-alpha-D-galactose => H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP"}
{"X":54236,"RHEA_ID":59558,"compounds":"H(+) + N,N'-diacetylchitobionate => H2O + N,N'-diacetylchitobiono-1,5-lactone"}
{"X":54237,"RHEA_ID":59559,"compounds":"H2O + N,N'-diacetylchitobiono-1,5-lactone <=> H(+) + N,N'-diacetylchitobionate"}
{"X":54238,"RHEA_ID":60842,"compounds":"a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + L-lysyl-[protein] => a 5'-end diphospho-adenosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein]"}
{"X":54239,"RHEA_ID":59561,"compounds":"H2O + N,N',N''-triacetylchitotriono-1,5-lactone => H(+) + N,N',N''-triacetylchitotrionate"}
{"X":54240,"RHEA_ID":59562,"compounds":"H(+) + N,N',N''-triacetylchitotrionate => H2O + N,N',N''-triacetylchitotriono-1,5-lactone"}
{"X":54241,"RHEA_ID":52867,"compounds":"an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP-beta-L-fucose <=> an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)"}
{"X":54242,"RHEA_ID":56209,"DIRECTION":"LR","MASTER_ID":56208,"metacyc":"2.4.99.4-RXN","compounds":"CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] => 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP + H(+)"}
{"X":54243,"RHEA_ID":59566,"compounds":"H(+) + N,N',N'',N'''-tetraacetylchitotetraonate => H2O + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone"}
{"X":54244,"RHEA_ID":52870,"compounds":"17alpha-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP => 17alpha-estradiol + UDP-alpha-D-glucuronate"}
{"X":54245,"RHEA_ID":57300,"compounds":"an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA + H2O = a 2'-deoxyguanosine in DNA + H(+) + lactate"}
{"X":54246,"RHEA_ID":56213,"DIRECTION":"LR","MASTER_ID":56212,"metacyc":"2.4.1.102-RXN","compounds":"O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP"}
{"X":54247,"RHEA_ID":59570,"compounds":"ADP + H(+) + L-homocarnosine + phosphate => 4-aminobutanoate + ATP + L-histidine"}
{"X":54248,"RHEA_ID":53974,"compounds":"(8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate => (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O"}
{"X":54249,"RHEA_ID":52875,"compounds":"17alpha-estradiol + UDP-alpha-D-glucuronate <=> 17alpha-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":54250,"RHEA_ID":56217,"DIRECTION":"LR","MASTER_ID":56216,"metacyc":"2.4.1.102-RXN","compounds":"O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP"}
{"X":54251,"RHEA_ID":57306,"compounds":"glycolate + GMP + H(+) => H2O + N(2)-(1-hydroxy-2-oxoethyl)-GMP"}
{"X":54252,"RHEA_ID":53978,"compounds":"(14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate => (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O"}
{"X":54253,"RHEA_ID":52879,"compounds":"16beta,17beta-estriol + UDP-alpha-D-glucuronate <=> 16beta,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":54254,"RHEA_ID":52880,"compounds":"16beta,17beta-estriol + UDP-alpha-D-glucuronate = 16beta,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":54255,"RHEA_ID":52881,"compounds":"16beta,17beta-estriol + UDP-alpha-D-glucuronate => 16beta,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":54256,"RHEA_ID":59577,"DIRECTION":"LR","MASTER_ID":59576,"metacyc":"X-METHYL-HIS-DIPEPTIDASE-RXN","compounds":"anserine + H2O => beta-alanine + N(pros)-methyl-L-histidine"}
{"X":54257,"RHEA_ID":52883,"compounds":"16beta,17beta-estriol + UDP-alpha-D-glucuronate <=> 16beta,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":54258,"RHEA_ID":52884,"DIRECTION":"UN","MASTER_ID":52884,"ec":"1.7.1.16","compounds":"H2O + N-phenylhydroxylamine + 2 NADP(+) = 2 H(+) + 2 NADPH + nitrobenzene"}
{"X":54259,"RHEA_ID":59580,"compounds":"hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester = CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester"}
{"X":54260,"RHEA_ID":60865,"compounds":"a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine => a 5'-end (N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-guanosine) in mRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":54261,"RHEA_ID":57316,"DIRECTION":"UN","MASTER_ID":57316,"ec":"2.7.1.224","compounds":"ATP + cytidine 5'-diphosphoramidate = ADP + cytidine 3'-phospho-5'-diphosphoramidate + H(+)"}
{"X":54262,"RHEA_ID":52888,"compounds":"N-phenylhydroxylamine + NADP(+) = H(+) + NADPH + nitrosobenzene"}
{"X":54263,"RHEA_ID":56228,"compounds":"(9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphocholine = (9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":54264,"RHEA_ID":59585,"compounds":"ATP + beta-alanine + L-lysine => ADP + beta-alanyl-L-lysine + H(+) + phosphate"}
{"X":54265,"RHEA_ID":56230,"compounds":"(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA => (9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphocholine"}
{"X":54266,"RHEA_ID":52892,"compounds":"H2O + NADP(+) + nitrosobenzene = H(+) + NADPH + nitrobenzene"}
{"X":54267,"RHEA_ID":53993,"compounds":"(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O => (14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate"}
{"X":54268,"RHEA_ID":60873,"compounds":"a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O => a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(7)-methylguanosine 5'-diphosphate"}
{"X":54269,"RHEA_ID":56234,"compounds":"[(1->4)-alpha-D-galacturonosyl](n-2) + alpha-D-galacturonosyl-(1->4)-D-galacturonate => [(1->4)-alpha-D-galacturonosyl](n) + H2O"}
{"X":54270,"RHEA_ID":52896,"DIRECTION":"UN","MASTER_ID":52896,"ec":"6.3.5.12","compounds":"2 ATP + 2 H2O + 2 L-glutamine + Ni-sirohydrochlorin = 2 ADP + 2 H(+) + 2 L-glutamate + Ni-sirohydrochlorin a,c-diamide + 2 phosphate"}
{"X":54271,"RHEA_ID":59592,"DIRECTION":"UN","MASTER_ID":59592,"ec":"6.3.2.11","compounds":"ATP + beta-alanine + L-arginine = ADP + beta-alanyl-L-arginine + H(+) + phosphate"}
{"X":54272,"RHEA_ID":59593,"compounds":"ATP + beta-alanine + L-arginine => ADP + beta-alanyl-L-arginine + H(+) + phosphate"}
{"X":54273,"RHEA_ID":56238,"compounds":"(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine"}
{"X":54274,"RHEA_ID":52900,"DIRECTION":"UN","MASTER_ID":52900,"ec":"6.3.3.7","compounds":"3 AH2 + ATP + H2O + Ni-sirohydrochlorin a,c-diamide = 15,17(3)-seco-F430-17(3)-acid + 3 A + ADP + phosphate"}
{"X":54275,"RHEA_ID":59608,"DIRECTION":"UN","MASTER_ID":59608,"ec":"3.4.13.4","compounds":"beta-alanyl-L-lysine + H2O = beta-alanine + L-lysine"}
{"X":54276,"RHEA_ID":60881,"compounds":"a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O => a 5'-end phospho-ribonucleoside in mRNA + H(+) + NAD(+)"}
{"X":54277,"RHEA_ID":56242,"compounds":"2-octanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl octanoate + apo--[retinol-binding protein] => 1,2-dioctanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein]"}
{"X":54278,"RHEA_ID":52904,"DIRECTION":"UN","MASTER_ID":52904,"ec":"6.4.1.9","compounds":"15,17(3)-seco-F430-17(3)-acid + ATP = ADP + coenzyme F430 + phosphate"}
{"X":54279,"RHEA_ID":59612,"DIRECTION":"UN","MASTER_ID":59612,"ec":"3.4.13.4","compounds":"beta-alanyl-L-ornithine + H2O = beta-alanine + L-ornithine"}
{"X":54280,"RHEA_ID":59613,"compounds":"beta-alanyl-L-ornithine + H2O => beta-alanine + L-ornithine"}
{"X":54281,"RHEA_ID":56246,"compounds":"2-hexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl hexadecanoate + apo--[retinol-binding protein] => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein]"}
{"X":54282,"RHEA_ID":52908,"DIRECTION":"UN","MASTER_ID":52908,"ec":"1.13.11.83","compounds":"3-dimethylallyl-4-hydroxyphenylpyruvate + O2 = 3-dimethylallyl-4-hydroxymandelate + CO2"}
{"X":54283,"RHEA_ID":52909,"DIRECTION":"LR","MASTER_ID":52908,"metacyc":"RXN-14671","compounds":"3-dimethylallyl-4-hydroxyphenylpyruvate + O2 => 3-dimethylallyl-4-hydroxymandelate + CO2"}
{"X":54284,"RHEA_ID":59617,"compounds":"beta-alanyl-L-arginine + H2O => beta-alanine + L-arginine"}
{"X":54285,"RHEA_ID":56250,"compounds":"2-dodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl dodecanoate + apo--[retinol-binding protein] => 1,2-didodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein]"}
{"X":54286,"RHEA_ID":52912,"DIRECTION":"UN","MASTER_ID":52912,"ec":"1.13.12.23","compounds":"3-dimethylallyl-4-hydroxymandelate + O2 = 3-dimethylallyl-4-hydroxybenzoate + CO2 + H2O"}
{"X":54287,"RHEA_ID":52913,"DIRECTION":"LR","MASTER_ID":52912,"metacyc":"RXN-14670","compounds":"3-dimethylallyl-4-hydroxymandelate + O2 => 3-dimethylallyl-4-hydroxybenzoate + CO2 + H2O"}
{"X":54288,"RHEA_ID":59621,"compounds":"H2O + N(2)-(4-aminobutanoyl)-L-lysine => 4-aminobutanoate + L-lysine"}
{"X":54289,"RHEA_ID":56254,"compounds":"H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-seryl-[protein] + UDP => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":54290,"RHEA_ID":52916,"compounds":"16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 17-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":54291,"RHEA_ID":52917,"compounds":"16alpha,17alpha-estriol + UDP-alpha-D-glucuronate => 16alpha,17alpha-estriol 17-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":54292,"RHEA_ID":56257,"DIRECTION":"LR","MASTER_ID":56256,"metacyc":"RXN-18949","compounds":"3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-threonyl-[protein] + UDP"}
{"X":54293,"RHEA_ID":56258,"compounds":"H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-threonyl-[protein] + UDP => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":54294,"RHEA_ID":52920,"compounds":"16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":54295,"RHEA_ID":52921,"compounds":"16alpha,17alpha-estriol + UDP-alpha-D-glucuronate => 16alpha,17alpha-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":54296,"RHEA_ID":56261,"DIRECTION":"LR","MASTER_ID":56260,"metacyc":"RXN-19001","compounds":"N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP-alpha-D-galactose => 4 H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP"}
{"X":54297,"RHEA_ID":56262,"compounds":"4 H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP => N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP-alpha-D-galactose"}
{"X":54298,"RHEA_ID":56263,"compounds":"N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP-alpha-D-galactose <=> 4 H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP"}
{"X":54299,"RHEA_ID":52925,"compounds":"16alpha,17alpha-estriol + UDP-alpha-D-glucuronate => 16alpha,17alpha-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":54300,"RHEA_ID":52926,"compounds":"16alpha,17alpha-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha,17alpha-estriol + UDP-alpha-D-glucuronate"}
{"X":54301,"RHEA_ID":56266,"compounds":"CMP + H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]"}
{"X":54302,"RHEA_ID":52928,"compounds":"cyclic di-3',5'-guanylate + 2 H2O = 2 GMP + 2 H(+)"}
{"X":54303,"RHEA_ID":56268,"compounds":"CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = CMP + H(+) + N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]"}
{"X":54304,"RHEA_ID":60913,"compounds":"cytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-methionine => H(+) + N(3)-methylcytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-homocysteine"}
{"X":54305,"RHEA_ID":56270,"compounds":"CMP + H(+) + N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]"}
{"X":54306,"RHEA_ID":52936,"compounds":"3-oxobutanoyl-[ACP] + acetyl-[ACP] + H2O = (3S)-hydroxy-3-methylglutaryl-[ACP] + H(+) + holo-[ACP]"}
{"X":54307,"RHEA_ID":52937,"compounds":"3-oxobutanoyl-[ACP] + acetyl-[ACP] + H2O => (3S)-hydroxy-3-methylglutaryl-[ACP] + H(+) + holo-[ACP]"}
{"X":54308,"RHEA_ID":60917,"compounds":"a cytidine in mRNA + S-adenosyl-L-methionine => an N(3)-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":54309,"RHEA_ID":56274,"compounds":"4 [Fe(II)cytochrome cL] + formate + 5 H(+) => 4 [Fe(III)cytochrome cL] + H2O + methanol"}
{"X":54310,"RHEA_ID":52940,"compounds":"chenodeoxycholate + UDP-alpha-D-glucuronate = chenodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP"}
{"X":54311,"RHEA_ID":54037,"DIRECTION":"LR","MASTER_ID":54036,"metacyc":"RXN-11189","compounds":"[mycoredoxin]-L-cysteine + arseno-mycothiol + H(+) => [mycoredoxin]-S-mycothiol-L-cysteine + arsenite"}
{"X":54312,"RHEA_ID":59645,"compounds":"D-xylobiono-1,5-lactone + H2O => D-xylobionate + H(+)"}
{"X":54313,"RHEA_ID":59646,"compounds":"D-xylobionate + H(+) => D-xylobiono-1,5-lactone + H2O"}
{"X":54314,"RHEA_ID":56279,"compounds":"ATP + L-proline <=> 3'-L-prolyl-AMP + diphosphate"}
{"X":54315,"RHEA_ID":59648,"compounds":"D-xylotriono-1,5-lactone + H2O = D-xylotrionate + H(+)"}
{"X":54316,"RHEA_ID":56281,"DIRECTION":"LR","MASTER_ID":56280,"metacyc":"RXN-19080","compounds":"3'-L-prolyl-AMP + holo-[peptidyl-carrier protein] => AMP + L-prolyl-[peptidyl-carrier protein]"}
{"X":54317,"RHEA_ID":59650,"compounds":"D-xylotrionate + H(+) => D-xylotriono-1,5-lactone + H2O"}
{"X":54318,"RHEA_ID":52948,"compounds":"deoxycholate + UDP-alpha-D-glucuronate = deoxycholoyl-24-O-(beta-D-glucuronate) + UDP"}
{"X":54319,"RHEA_ID":59652,"compounds":"D-xylotetraono-1,5-lactone + H2O = D-xylotetraonate + H(+)"}
{"X":54320,"RHEA_ID":59653,"compounds":"D-xylotetraono-1,5-lactone + H2O => D-xylotetraonate + H(+)"}
{"X":54321,"RHEA_ID":59654,"compounds":"D-xylotetraonate + H(+) => D-xylotetraono-1,5-lactone + H2O"}
{"X":54322,"RHEA_ID":52952,"compounds":"lithocholate + UDP-alpha-D-glucuronate = lithocholoyl-24-O-(beta-D-glucuronate) + UDP"}
{"X":54323,"RHEA_ID":56288,"DIRECTION":"UN","MASTER_ID":56288,"ec":"1.14.14.74","compounds":"albendazole + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + hydroxyalbendazole + oxidized [NADPH--hemoprotein reductase]"}
{"X":54324,"RHEA_ID":59657,"compounds":"D-cellotriose + O2 => D-cellotriono-1,5-lactone + H2O2"}
{"X":54325,"RHEA_ID":59658,"compounds":"D-cellotriono-1,5-lactone + H2O2 => D-cellotriose + O2"}
{"X":54326,"RHEA_ID":52956,"compounds":"hyodeoxycholate + UDP-alpha-D-glucuronate = hyodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP"}
{"X":54327,"RHEA_ID":54053,"DIRECTION":"LR","MASTER_ID":54052,"metacyc":"RXN-18827","compounds":"(2E,6E)-farnesyl diphosphate + H2O => diphosphate + tau-cadinol"}
{"X":54328,"RHEA_ID":57387,"compounds":"(13S,14R)-1,13-dihydroxy-N-methylcanadine + acetyl-CoA <=> (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + CoA"}
{"X":54329,"RHEA_ID":56294,"compounds":"4'-hydroxyfenbendazole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => fenbendazole + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":54330,"RHEA_ID":52960,"compounds":"hyocholate + UDP-alpha-D-glucuronate = hyocholoyl-24-O-(beta-D-glucuronate) + UDP"}
{"X":54331,"RHEA_ID":52961,"compounds":"hyocholate + UDP-alpha-D-glucuronate => hyocholoyl-24-O-(beta-D-glucuronate) + UDP"}
{"X":54332,"RHEA_ID":57391,"compounds":"(13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] <=> (13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54333,"RHEA_ID":59666,"compounds":"D-cellopentaono-1,5-lactone + H2O2 => D-cellopentaose + O2"}
{"X":54334,"RHEA_ID":52964,"compounds":"hyodeoxycholate + UDP-alpha-D-glucuronate = H(+) + hyodeoxycholate 6-O-(beta-D-glucuronate) + UDP"}
{"X":54335,"RHEA_ID":59668,"compounds":"D-cellohexaose + O2 = D-cellohexaono-1,5-lactone + H2O2"}
{"X":54336,"RHEA_ID":56301,"DIRECTION":"LR","MASTER_ID":56300,"ecocyc":"RXN-18703","metacyc":"RXN-18703","compounds":"[thioredoxin]-dithiol + S-sulfanyl-L-cysteinyl-[protein] => [thioredoxin]-disulfide + H(+) + hydrogen sulfide + L-cysteinyl-[protein]"}
{"X":54337,"RHEA_ID":59670,"compounds":"D-cellohexaono-1,5-lactone + H2O2 => D-cellohexaose + O2"}
{"X":54338,"RHEA_ID":52968,"compounds":"hyocholate + UDP-alpha-D-glucuronate = H(+) + hyocholate 6-O-(beta-D-glucuronate) + UDP"}
{"X":54339,"RHEA_ID":56304,"DIRECTION":"UN","MASTER_ID":56304,"ec":"2.7.9.6","compounds":"ATP + H2O + rifampicin = 21-phosphorifampicin + AMP + 2 H(+) + phosphate"}
{"X":54340,"RHEA_ID":52970,"compounds":"H(+) + hyocholate 6-O-(beta-D-glucuronate) + UDP => hyocholate + UDP-alpha-D-glucuronate"}
{"X":54341,"RHEA_ID":57400,"DIRECTION":"UN","MASTER_ID":57400,"ec":"3.1.1.105","compounds":"3-O-acetylpapaveroxine + H2O = acetate + H(+) + narcotine hemiacetal"}
{"X":54342,"RHEA_ID":52972,"compounds":"a C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] = a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin]"}
{"X":54343,"RHEA_ID":56308,"DIRECTION":"UN","MASTER_ID":56308,"ec":"1.14.19.54","compounds":"(S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] = 1,2-dehydroreticuline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54344,"RHEA_ID":56309,"DIRECTION":"LR","MASTER_ID":56308,"metacyc":"RXN-8142","compounds":"(S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] => 1,2-dehydroreticuline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54345,"RHEA_ID":56310,"compounds":"1,2-dehydroreticuline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":54346,"RHEA_ID":52976,"compounds":"a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] = a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin]"}
{"X":54347,"RHEA_ID":55175,"compounds":"2-oxoglutarate + hexanoyl-CoA + O2 <=> 2-hydroxyhexanoyl-CoA + CO2 + succinate"}
{"X":54348,"RHEA_ID":56313,"DIRECTION":"LR","MASTER_ID":56312,"reactome":"R-HSA-2023973.2","compounds":"3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O => 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + 2 H(+) + phosphate"}
{"X":54349,"RHEA_ID":56314,"compounds":"3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + 2 H(+) + phosphate => 3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O"}
{"X":54350,"RHEA_ID":52980,"compounds":"a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] = 7-oxoheptanoyl-[ACP] + a fatty aldehyde + H(+) + 2 H2O + oxidized [flavodoxin]"}
{"X":54351,"RHEA_ID":56316,"compounds":"3-amino-4-hydroxybenzoate + acetyl-CoA = 3-acetylamino-4-hydroxybenzoate + CoA"}
{"X":54352,"RHEA_ID":60961,"compounds":"18-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose => (9Z)-18-hydroxyoctadec-9-enoate 18-O-beta-D-glucoside + H(+) + UDP"}
{"X":54353,"RHEA_ID":59686,"compounds":"D-maltohexaono-1,5-lactone + H2O2 => D-maltohexaose + O2"}
{"X":54354,"RHEA_ID":56319,"compounds":"3-amino-4-hydroxybenzoate + acetyl-CoA <=> 3-acetylamino-4-hydroxybenzoate + CoA"}
{"X":54355,"RHEA_ID":56320,"compounds":"a 5-hydroxy anthocyanidin + UDP-alpha-D-glucose = an anthocyanin 5-O-beta-D-glucoside + H(+) + UDP"}
{"X":54356,"RHEA_ID":60965,"compounds":"(9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + UDP-alpha-D-glucose => (9Z)-17-hydroxyoctadec-9-enoate 17-O-sophoroside + H(+) + UDP"}
{"X":54357,"RHEA_ID":59690,"compounds":"D-maltoheptaono-1,5-lactone + H2O2 => D-maltoheptaose + O2"}
{"X":54358,"RHEA_ID":56323,"compounds":"a 5-hydroxy anthocyanidin + UDP-alpha-D-glucose <=> an anthocyanin 5-O-beta-D-glucoside + H(+) + UDP"}
{"X":54359,"RHEA_ID":59692,"compounds":"D-cellotriono-1,5-lactone + H2O = D-cellotrionate + H(+)"}
{"X":54360,"RHEA_ID":59693,"compounds":"D-cellotriono-1,5-lactone + H2O => D-cellotrionate + H(+)"}
{"X":54361,"RHEA_ID":59694,"compounds":"D-cellotrionate + H(+) => D-cellotriono-1,5-lactone + H2O"}
{"X":54362,"RHEA_ID":52992,"compounds":"[deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + [eIF5A protein]-L-lysine = [deoxyhypusine synthase]-L-lysine + [eIF5A protein]-N-(4-aminobutylidene)-L-lysine"}
{"X":54363,"RHEA_ID":56328,"compounds":"5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + H2O = 5'-triphosphoadenylyl-(2'->5')-adenosine + AMP + H(+)"}
{"X":54364,"RHEA_ID":56329,"compounds":"5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + H2O => 5'-triphosphoadenylyl-(2'->5')-adenosine + AMP + H(+)"}
{"X":54365,"RHEA_ID":59698,"compounds":"D-cellotetraonate + H(+) => D-cellotetraono-1,5-lactone + H2O"}
{"X":54366,"RHEA_ID":52996,"compounds":"[eIF5A protein]-N-(4-aminobutylidene)-L-lysine + H(+) + NADH = [eIF5A protein]-deoxyhypusine + NAD(+)"}
{"X":54367,"RHEA_ID":56332,"compounds":"5'-triphosphoadenylyl-(2'->5')-adenosine + H2O = AMP + ATP + H(+)"}
{"X":54368,"RHEA_ID":52998,"compounds":"[eIF5A protein]-deoxyhypusine + NAD(+) => [eIF5A protein]-N-(4-aminobutylidene)-L-lysine + H(+) + NADH"}
{"X":54369,"RHEA_ID":59702,"compounds":"D-cellopentaonate + H(+) => D-cellopentaono-1,5-lactone + H2O"}
{"X":54370,"RHEA_ID":59703,"compounds":"D-cellopentaono-1,5-lactone + H2O <=> D-cellopentaonate + H(+)"}
{"X":54371,"RHEA_ID":56336,"DIRECTION":"UN","MASTER_ID":56336,"ec":"1.14.14.76","compounds":"ent-isokaurene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = ent-isokaurene-2beta,3beta-diol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":54372,"RHEA_ID":53002,"compounds":"5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP => 17beta-hydroxy-5alpha-androstan-3-one + UDP-alpha-D-glucuronate"}
{"X":54373,"RHEA_ID":59706,"compounds":"D-cellohexaonate + H(+) => D-cellohexaono-1,5-lactone + H2O"}
{"X":54374,"RHEA_ID":53004,"compounds":"2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":54375,"RHEA_ID":56340,"compounds":"ent-isokauren-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = ent-isokaurene-2beta,3beta-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54376,"RHEA_ID":56341,"DIRECTION":"LR","MASTER_ID":56340,"metacyc":"RXN-18938","compounds":"ent-isokauren-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => ent-isokaurene-2beta,3beta-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54377,"RHEA_ID":59710,"compounds":"D-maltotrionate + H(+) => D-maltotriono-1,5-lactone + H2O"}
{"X":54378,"RHEA_ID":59711,"compounds":"D-maltotriono-1,5-lactone + H2O <=> D-maltotrionate + H(+)"}
{"X":54379,"RHEA_ID":54103,"compounds":"N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":54380,"RHEA_ID":53010,"compounds":"di-trans,poly-cis-polyprenyl diphosphate + n diphosphate => (2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate"}
{"X":54381,"RHEA_ID":59714,"compounds":"D-maltotetraonate + H(+) => D-maltotetraono-1,5-lactone + H2O"}
{"X":54382,"RHEA_ID":53012,"compounds":"2,5-dichlorohydroquinone + 2 glutathione = chloride + chlorohydroquinone + glutathione disulfide + H(+)"}
{"X":54383,"RHEA_ID":54106,"compounds":"H(+) + N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine"}
{"X":54384,"RHEA_ID":56349,"DIRECTION":"LR","MASTER_ID":56348,"metacyc":"RXN-19063","compounds":"4-hydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 => 2,4-dibromophenol + CO2 + 4 H2O + 2 NADP(+)"}
{"X":54385,"RHEA_ID":59718,"compounds":"D-maltopentaonate + H(+) => D-maltopentaono-1,5-lactone + H2O"}
{"X":54386,"RHEA_ID":59719,"compounds":"D-maltopentaono-1,5-lactone + H2O <=> D-maltopentaonate + H(+)"}
{"X":54387,"RHEA_ID":57446,"compounds":"C-terminal detyrosinated L-glutamyl-L-glutamyl-[alpha-tubulin] + L-tyrosine => C-terminal L-tyrosyl-L-glutamyl-L-glutamyl-[alpha-tubulin] + H2O"}
{"X":54388,"RHEA_ID":53018,"compounds":"chloride + glutathione disulfide + H(+) + hydroquinone => chlorohydroquinone + 2 glutathione"}
{"X":54389,"RHEA_ID":56354,"compounds":"3-bromo-4-hydroxybenzoate + 2 H2O + NADP(+) => 4-hydroxybenzoate + bromide + 2 H(+) + NADPH + O2"}
{"X":54390,"RHEA_ID":59723,"compounds":"D-maltohexaono-1,5-lactone + H2O <=> D-maltohexaonate + H(+)"}
{"X":54391,"RHEA_ID":56356,"compounds":"3-bromo-4-hydroxybenzoate + bromide + 3 H(+) + NADPH + O2 = 2,4-dibromophenol + CO2 + 2 H2O + NADP(+)"}
{"X":54392,"RHEA_ID":53022,"compounds":"a 2-oxocarboxylate + a plastoquinol + NH4(+) => a plastoquinone + an L-alpha-amino acid + H2O"}
{"X":54393,"RHEA_ID":59726,"compounds":"D-maltoheptaonate + H(+) => D-maltoheptaono-1,5-lactone + H2O"}
{"X":54394,"RHEA_ID":57453,"compounds":"L-glutaminyl-[protein] + S-adenosyl-L-methionine => H(+) + N(5)-methyl-L-glutaminyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":54395,"RHEA_ID":58565,"compounds":"15alpha-stemmadenine + NADP(+) => 15alpha-stemmadenine intermediate II + 2 H(+) + NADPH"}
{"X":54396,"RHEA_ID":53026,"compounds":"5-guanidino-2-oxopentanoate + a plastoquinol + NH4(+) => a plastoquinone + H2O + L-arginine"}
{"X":54397,"RHEA_ID":53027,"compounds":"a plastoquinone + H2O + L-arginine <=> 5-guanidino-2-oxopentanoate + a plastoquinol + NH4(+)"}
{"X":54398,"RHEA_ID":57457,"compounds":"trans-sinapate + UDP-alpha-D-glucose => 4-O-(beta-D-glucosyl)-trans-sinapate + H(+) + UDP"}
{"X":54399,"RHEA_ID":56364,"compounds":"13-dihydrocarminomycin + H(+) + NADPH + O2 = carminomycin + 2 H2O + NADP(+)"}
{"X":54400,"RHEA_ID":53030,"compounds":"H(+) + lithocholoyl-3-O-(beta-D-glucuronate) + UDP => lithocholate + UDP-alpha-D-glucuronate"}
{"X":54401,"RHEA_ID":53031,"compounds":"lithocholate + UDP-alpha-D-glucuronate <=> H(+) + lithocholoyl-3-O-(beta-D-glucuronate) + UDP"}
{"X":54402,"RHEA_ID":57461,"compounds":"(E)-sinapoyl alcohol + UDP-alpha-D-glucose => 4-O-(beta-D-glucosyl)-trans-4-sinapoyl alcohol + H(+) + UDP"}
{"X":54403,"RHEA_ID":56368,"DIRECTION":"UN","MASTER_ID":56368,"ec":"1.14.19.55","compounds":"3,4-dihydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 = 3,5-dibromobenzene-1,2-diol + CO2 + 4 H2O + 2 NADP(+)"}
{"X":54404,"RHEA_ID":54127,"compounds":"coelenterazine h dioxetanone <=> CO2 + excited coelenteramide h monoanion + H(+)"}
{"X":54405,"RHEA_ID":53035,"compounds":"2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate <=> 17beta-estradiol 2-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":54406,"RHEA_ID":59739,"compounds":"L-cysteinyl-[protein] + tetradecanoyl-CoA <=> CoA + S-tetradecanoyl-L-cysteinyl-[protein]"}
{"X":54407,"RHEA_ID":54130,"compounds":"3-O-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP => 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":54408,"RHEA_ID":53038,"compounds":"4-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP => 4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate"}
{"X":54409,"RHEA_ID":53039,"compounds":"4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate <=> 4-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":54410,"RHEA_ID":53040,"compounds":"4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 4-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":54411,"RHEA_ID":56376,"compounds":"3-bromo-4,5-dihydroxybenzoate + bromide + 3 H(+) + NADPH + O2 = 3,5-dibromobenzene-1,2-diol + CO2 + 2 H2O + NADP(+)"}
{"X":54412,"RHEA_ID":55240,"compounds":"1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H2O = (9Z)-octadecenoate + 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H(+)"}
{"X":54413,"RHEA_ID":58583,"compounds":"dihydroprecondylocarpine acetate <=> acetate + catharanthine + H(+)"}
{"X":54414,"RHEA_ID":53044,"DIRECTION":"UN","MASTER_ID":53044,"ec":"2.1.1.296","compounds":"a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine = a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":54415,"RHEA_ID":53045,"DIRECTION":"LR","MASTER_ID":53044,"metacyc":"RXN-14928","compounds":"a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine => a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":54416,"RHEA_ID":56381,"DIRECTION":"LR","MASTER_ID":56380,"metacyc":"RXN-19067","compounds":"(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 chloride + 2 FADH2 + 2 O2 => (4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 FAD + 4 H2O"}
{"X":54417,"RHEA_ID":58587,"compounds":"dihydroprecondylocarpine acetate <=> (-)-tabersonine + acetate + H(+)"}
{"X":54418,"RHEA_ID":59751,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + L-cysteinyl-[protein] <=> CoA + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-cysteinyl-[protein]"}
{"X":54419,"RHEA_ID":53049,"compounds":"2-hydroxyestrone + UDP-alpha-D-glucuronate => 2-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":54420,"RHEA_ID":53050,"compounds":"2-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP => 2-hydroxyestrone + UDP-alpha-D-glucuronate"}
{"X":54421,"RHEA_ID":56386,"compounds":"(5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O => (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2"}
{"X":54422,"RHEA_ID":61075,"compounds":"(-)-(R)-19-hydroxytabersonine + acetyl-CoA <=> (-)-(R)-19-O-acetyltabersonine + CoA"}
{"X":54423,"RHEA_ID":59764,"compounds":"L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + octadecanoyl-CoA = CoA + H(+) + N(6)-octadecanoyl-L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein]"}
{"X":54424,"RHEA_ID":53054,"compounds":"4-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP => 4-hydroxyestrone + UDP-alpha-D-glucuronate"}
{"X":54425,"RHEA_ID":56390,"compounds":"(4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O => (5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2"}
{"X":54426,"RHEA_ID":57493,"compounds":"H2O + oxaloacetate + propanoyl-CoA => 2-methylcitrate + CoA + H(+)"}
{"X":54427,"RHEA_ID":59768,"compounds":"hexadecanoyl-CoA + L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein] = CoA + H(+) + N(6)-hexadecanoyl-L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein]"}
{"X":54428,"RHEA_ID":53058,"compounds":"H(+) + isowyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine => 4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine"}
{"X":54429,"RHEA_ID":56394,"compounds":"(3R)-hydroxybutanoate dimer + [(3R)-hydroxybutanoate](n-2) + H(+) => [(3R)-hydroxybutanoate](n) + H2O"}
{"X":54430,"RHEA_ID":59771,"compounds":"hexadecanoyl-CoA + L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein] <=> CoA + H(+) + N(6)-hexadecanoyl-L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein]"}
{"X":54431,"RHEA_ID":56396,"DIRECTION":"UN","MASTER_ID":56396,"ec":"3.1.1.75","compounds":"[(3R)-hydroxybutanoate](n) + H2O = (3R)-hydroxybutanoate trimer + [(3R)-hydroxybutanoate](n-3) + H(+)"}
{"X":54432,"RHEA_ID":53062,"compounds":"estrone 4-O-(beta-D-glucuronate) + H(+) + UDP => 4-hydroxyestrone + UDP-alpha-D-glucuronate"}
{"X":54433,"RHEA_ID":56398,"compounds":"(3R)-hydroxybutanoate trimer + [(3R)-hydroxybutanoate](n-3) + H(+) => [(3R)-hydroxybutanoate](n) + H2O"}
{"X":54434,"RHEA_ID":53065,"compounds":"2-methoxyestrone + UDP-alpha-D-glucuronate => 2-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":54435,"RHEA_ID":53066,"compounds":"2-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP => 2-methoxyestrone + UDP-alpha-D-glucuronate"}
{"X":54436,"RHEA_ID":56402,"compounds":"(3R)-hydroxybutanoate tetramer + [(3R)-hydroxybutanoate](n-4) + H(+) => [(3R)-hydroxybutanoate](n) + H2O"}
{"X":54437,"RHEA_ID":59787,"compounds":"H2O + NADP(+) + pseudopaline <=> (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADPH"}
{"X":54438,"RHEA_ID":56404,"DIRECTION":"UN","MASTER_ID":56404,"ec":"3.1.1.75","compounds":"[(3R)-hydroxybutanoate](n) + H2O = (3R)-hydroxybutanoate pentamer + [(3R)-hydroxybutanoate](n-5) + H(+)"}
{"X":54439,"RHEA_ID":53070,"compounds":"4-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP => 4-methoxyestrone + UDP-alpha-D-glucuronate"}
{"X":54440,"RHEA_ID":56406,"compounds":"(3R)-hydroxybutanoate pentamer + [(3R)-hydroxybutanoate](n-5) + H(+) => [(3R)-hydroxybutanoate](n) + H2O"}
{"X":54441,"RHEA_ID":53072,"compounds":"2-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":54442,"RHEA_ID":59792,"compounds":"H2O + NADP(+) + yersinopine = (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate"}
{"X":54443,"RHEA_ID":53074,"compounds":"2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP => 2-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate"}
{"X":54444,"RHEA_ID":56410,"compounds":"1-(9Z-octadecaenoyl)-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA => (9Z,12Z,15Z)-octadecatrienoyl-CoA + a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine"}
{"X":54445,"RHEA_ID":59795,"compounds":"H2O + NADP(+) + yersinopine <=> (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate"}
{"X":54446,"RHEA_ID":56412,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-ditetradecanoyl-sn-glycerol"}
{"X":54447,"RHEA_ID":53078,"compounds":"5-methylcytidine(34) in mitochondrial tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(34) in mitochondrial tRNA + S-adenosyl-L-methionine"}
{"X":54448,"RHEA_ID":53079,"compounds":"cytidine(34) in mitochondrial tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(34) in mitochondrial tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":54449,"RHEA_ID":56415,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-ditetradecanoyl-sn-glycerol"}
{"X":54450,"RHEA_ID":59800,"compounds":"decanoyl-CoA + L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein] = CoA + H(+) + N(6)-decanoyl-L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein]"}
{"X":54451,"RHEA_ID":53082,"compounds":"4-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP => 4-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate"}
{"X":54452,"RHEA_ID":53083,"compounds":"4-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate <=> 4-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP"}
{"X":54453,"RHEA_ID":56419,"DIRECTION":"BI","MASTER_ID":56416,"metacyc":"RXN-19624","compounds":"2-O-(alpha-D-glucopyranosyl)glycerol + phosphate <=> alpha-D-glucose 1-phosphate + glycerol"}
{"X":54454,"RHEA_ID":53085,"compounds":"[(1->2)-beta-D-glucosyl](n) + UDP-alpha-D-glucose => [(1->2)-beta-D-glucosyl](n+1) + H(+) + UDP"}
{"X":54455,"RHEA_ID":53087,"compounds":"[(1->2)-beta-D-glucosyl](n) + UDP-alpha-D-glucose <=> [(1->2)-beta-D-glucosyl](n+1) + H(+) + UDP"}
{"X":54456,"RHEA_ID":56423,"compounds":"apo-[D-alanyl-carrier protein] + CoA <=> adenosine 3',5'-bisphosphate + H(+) + holo-[D-alanyl-carrier protein]"}
{"X":54457,"RHEA_ID":56424,"compounds":"H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = (9Z,12Z)-octadecadienoate + H(+) + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":54458,"RHEA_ID":53090,"compounds":"2-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine => 2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine"}
{"X":54459,"RHEA_ID":53091,"compounds":"2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine <=> 2-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine"}
{"X":54460,"RHEA_ID":56427,"compounds":"H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z,12Z)-octadecadienoate + H(+) + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":54461,"RHEA_ID":56428,"compounds":"1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":54462,"RHEA_ID":53094,"compounds":"2-hydroxy-3-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine => 2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine"}
{"X":54463,"RHEA_ID":53095,"compounds":"2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine <=> 2-hydroxy-3-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine"}
{"X":54464,"RHEA_ID":56431,"compounds":"1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z)-octadecadienoate + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":54465,"RHEA_ID":56432,"compounds":"1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate"}
{"X":54466,"RHEA_ID":53098,"compounds":"4-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine => 4-hydroxy-17beta-estradiol + S-adenosyl-L-methionine"}
{"X":54467,"RHEA_ID":53099,"compounds":"4-hydroxy-17beta-estradiol + S-adenosyl-L-methionine <=> 4-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine"}
{"X":54468,"RHEA_ID":56435,"compounds":"1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate"}
{"X":54469,"RHEA_ID":56436,"compounds":"1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":54470,"RHEA_ID":53102,"compounds":"2-methoxyestrone + H(+) + S-adenosyl-L-homocysteine => 2-hydroxyestrone + S-adenosyl-L-methionine"}
{"X":54471,"RHEA_ID":53103,"compounds":"2-hydroxyestrone + S-adenosyl-L-methionine <=> 2-methoxyestrone + H(+) + S-adenosyl-L-homocysteine"}
{"X":54472,"RHEA_ID":56439,"compounds":"1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":54473,"RHEA_ID":53105,"compounds":"4-hydroxyestrone + S-adenosyl-L-methionine => 4-methoxyestrone + H(+) + S-adenosyl-L-homocysteine"}
{"X":54474,"RHEA_ID":53106,"compounds":"4-methoxyestrone + H(+) + S-adenosyl-L-homocysteine => 4-hydroxyestrone + S-adenosyl-L-methionine"}
{"X":54475,"RHEA_ID":56442,"compounds":"1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":54476,"RHEA_ID":56443,"compounds":"1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":54477,"RHEA_ID":53109,"compounds":"2-hydroxyestrone + S-adenosyl-L-methionine => 2-hydroxy-3-methoxy-estrone + H(+) + S-adenosyl-L-homocysteine"}
{"X":54478,"RHEA_ID":53110,"compounds":"2-hydroxy-3-methoxy-estrone + H(+) + S-adenosyl-L-homocysteine => 2-hydroxyestrone + S-adenosyl-L-methionine"}
{"X":54479,"RHEA_ID":56446,"compounds":"2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate => 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":54480,"RHEA_ID":53112,"compounds":"3alpha-hydroxy-5alpha-androstane 17-O-(beta-D-glucuronate) + NADP(+) = 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + NADPH"}
{"X":54481,"RHEA_ID":56448,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)"}
{"X":54482,"RHEA_ID":59841,"DIRECTION":"LR","MASTER_ID":59840,"metacyc":"RXN-10890","compounds":"(6S)-5,6,7,8-tetrahydrofolate + syringate => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-O-methylgallate"}
{"X":54483,"RHEA_ID":54208,"compounds":"2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O"}
{"X":54484,"RHEA_ID":53116,"compounds":"an 11beta-hydroxysteroid + NAD(+) = an 11-oxosteroid + H(+) + NADH"}
{"X":54485,"RHEA_ID":53117,"compounds":"an 11beta-hydroxysteroid + NAD(+) => an 11-oxosteroid + H(+) + NADH"}
{"X":54486,"RHEA_ID":53118,"compounds":"an 11-oxosteroid + H(+) + NADH => an 11beta-hydroxysteroid + NAD(+)"}
{"X":54487,"RHEA_ID":53119,"compounds":"an 11beta-hydroxysteroid + NAD(+) <=> an 11-oxosteroid + H(+) + NADH"}
{"X":54488,"RHEA_ID":53120,"compounds":"(3beta,5alpha,17beta)-3-hydroxyandrostan-17-yl sulfate + NADP(+) = 5alpha-dihydrotestosterone sulfate + H(+) + NADPH"}
{"X":54489,"RHEA_ID":59848,"compounds":"(2R,3S)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH = (S)-tetrahydrodehydrodiconiferyl alcohol + NADP(+)"}
{"X":54490,"RHEA_ID":53122,"compounds":"5alpha-dihydrotestosterone sulfate + H(+) + NADPH => (3beta,5alpha,17beta)-3-hydroxyandrostan-17-yl sulfate + NADP(+)"}
{"X":54491,"RHEA_ID":56458,"compounds":"12-epi-fischerindole U => 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole"}
{"X":54492,"RHEA_ID":53124,"DIRECTION":"UN","MASTER_ID":53124,"ec":"5.5.1.18","compounds":"all-trans-lycopene = delta-carotene"}
{"X":54493,"RHEA_ID":53125,"DIRECTION":"LR","MASTER_ID":53124,"metacyc":"RXN1F-147","compounds":"all-trans-lycopene => delta-carotene"}
{"X":54494,"RHEA_ID":57563,"compounds":"(+)-cis-trans-nepetalactol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 7-deoxyloganetate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}
{"X":54495,"RHEA_ID":56462,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine => H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":54496,"RHEA_ID":53128,"DIRECTION":"UN","MASTER_ID":53128,"ec":"5.5.1.18","compounds":"delta-carotene = epsilon-carotene"}
{"X":54497,"RHEA_ID":56464,"compounds":"1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H2O = 1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}
{"X":54498,"RHEA_ID":53130,"compounds":"epsilon-carotene => delta-carotene"}
{"X":54499,"RHEA_ID":56466,"compounds":"1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => 1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H2O"}
{"X":54500,"RHEA_ID":53132,"compounds":"A + a 3-oxo-Delta(4)-steroid = a 3-oxo-Delta(1,4)-steroid + AH2"}
{"X":54501,"RHEA_ID":59860,"compounds":"3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->6)-N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP"}
{"X":54502,"RHEA_ID":53134,"compounds":"a 3-oxo-Delta(1,4)-steroid + AH2 => A + a 3-oxo-Delta(4)-steroid"}
{"X":54503,"RHEA_ID":56470,"compounds":"(3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 FAD + 6 H2O => (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 bromide + 3 FADH2 + 3 O2"}
{"X":54504,"RHEA_ID":53136,"compounds":"(3beta,5alpha,17beta)-3-hydroxy-androstan-17-yl sulfate + NADP(+) = 5alpha-dihydrotestosterone sulfate + H(+) + NADPH"}
{"X":54505,"RHEA_ID":59864,"compounds":"(indol-3-yl)butanoate + ATP + L-glutamine = (indol-3-yl)butanoyl-L-glutamine + AMP + diphosphate + H(+)"}
{"X":54506,"RHEA_ID":53138,"compounds":"5alpha-dihydrotestosterone sulfate + H(+) + NADPH => (3beta,5alpha,17beta)-3-hydroxy-androstan-17-yl sulfate + NADP(+)"}
{"X":54507,"RHEA_ID":59866,"compounds":"(indol-3-yl)butanoyl-L-glutamine + AMP + diphosphate + H(+) => (indol-3-yl)butanoate + ATP + L-glutamine"}
{"X":54508,"RHEA_ID":53140,"compounds":"N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(8,9-epoxy-5Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]"}
{"X":54509,"RHEA_ID":54234,"compounds":"1,2-dioctanoyl-sn-glycero-3-phosphocholine + CMP + H(+) => 1,2-dioctanoyl-sn-glycerol + CDP-choline"}
{"X":54510,"RHEA_ID":53142,"compounds":"H(+) + H2O + N-(8,9-epoxy-5Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase] => N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":54511,"RHEA_ID":56478,"compounds":"(4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O => (5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2"}
{"X":54512,"RHEA_ID":53144,"compounds":"N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(11,12-epoxy-5Z,8Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]"}
{"X":54513,"RHEA_ID":56480,"compounds":"(4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 = (3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O"}
{"X":54514,"RHEA_ID":53146,"compounds":"H(+) + H2O + N-(11,12-epoxy-5Z,8Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase] => N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":54515,"RHEA_ID":61170,"compounds":"H(+) + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP => quercetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose"}
{"X":54516,"RHEA_ID":53148,"compounds":"N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(14,15-epoxy-5Z,8Z,11Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]"}
{"X":54517,"RHEA_ID":56484,"compounds":"3 O2 + oleanolate + 3 reduced [NADPH--hemoprotein reductase] = gypsogenate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}
{"X":54518,"RHEA_ID":53150,"compounds":"H(+) + H2O + N-(14,15-epoxy-5Z,8Z,11Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase] => N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":54519,"RHEA_ID":56486,"compounds":"gypsogenate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 3 O2 + oleanolate + 3 reduced [NADPH--hemoprotein reductase]"}
{"X":54520,"RHEA_ID":53152,"compounds":"N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]"}
{"X":54521,"RHEA_ID":53153,"compounds":"N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N-(20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]"}
{"X":54522,"RHEA_ID":53154,"compounds":"H(+) + H2O + N-(20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase] => N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":54523,"RHEA_ID":56490,"compounds":"H(+) + H2O + hederagenin + oxidized [NADPH--hemoprotein reductase] => O2 + oleanolate + reduced [NADPH--hemoprotein reductase]"}
{"X":54524,"RHEA_ID":53156,"compounds":"N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(5,6-epoxy-8Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]"}
{"X":54525,"RHEA_ID":53157,"compounds":"N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N-(5,6-epoxy-8Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]"}
{"X":54526,"RHEA_ID":53158,"compounds":"H(+) + H2O + N-(5,6-epoxy-8Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase] => N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":54527,"RHEA_ID":57596,"compounds":"(S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase] = (2S)-2-hydroxyeriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54528,"RHEA_ID":53160,"compounds":"H2O + N-acyl-sn-glycero-3-phosphoethanolamine = an N-acylethanolamine + H(+) + sn-glycerol 3-phosphate"}
{"X":54529,"RHEA_ID":53161,"compounds":"H2O + N-acyl-sn-glycero-3-phosphoethanolamine => an N-acylethanolamine + H(+) + sn-glycerol 3-phosphate"}
{"X":54530,"RHEA_ID":59889,"compounds":"4-chloro-L-lysine + AH2 + O2 => A + formaldehyde + H2O + L-2-amino-4-chloropent-4-enoate + NH4(+)"}
{"X":54531,"RHEA_ID":56498,"compounds":"gypsogenate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => gypsogenin + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":54532,"RHEA_ID":53164,"compounds":"H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine = a 1-acyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)"}
{"X":54533,"RHEA_ID":53165,"compounds":"H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine => a 1-acyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)"}
{"X":54534,"RHEA_ID":56501,"DIRECTION":"LR","MASTER_ID":56500,"metacyc":"RXN-15649","compounds":"(R)-3,5-bisphosphomevalonate + H(+) => CO2 + isopentenyl phosphate + phosphate"}
{"X":54535,"RHEA_ID":53167,"compounds":"H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine <=> a 1-acyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)"}
{"X":54536,"RHEA_ID":53168,"compounds":"H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}
{"X":54537,"RHEA_ID":59896,"compounds":"ATP + L-glutamate + L-propargylglycine = ADP + H(+) + L-gamma-glutamyl-L-propargylglycine + phosphate"}
{"X":54538,"RHEA_ID":57607,"compounds":"2 [Fe(II)-cytochrome b5] + a 1-tetracosanoyl-2-acyl-phosphoglycerolipid + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a 1-[(15Z)-tetracos-15-enoyl]-2-acyl-phosphoglycerolipid + 2 H2O"}
{"X":54539,"RHEA_ID":61194,"compounds":"CoA + H(+) + myricetin 3-O-[(6-O-(E)-4-coumaroyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside] => (E)-4-coumaroyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside]"}
{"X":54540,"RHEA_ID":53172,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + ethanolamine + H(+)"}
{"X":54541,"RHEA_ID":53173,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphate + ethanolamine + H(+)"}
{"X":54542,"RHEA_ID":56509,"compounds":"3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate => 3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H(+) + UDP"}
{"X":54543,"RHEA_ID":59902,"compounds":"CO2 + L-gamma-glutamyl-(3R)-L-beta-ethynylserine + succinate => 2-oxoglutarate + L-gamma-glutamyl-L-propargylglycine + O2"}
{"X":54544,"RHEA_ID":53176,"compounds":"H2O + N-acyl-1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)"}
{"X":54545,"RHEA_ID":56512,"compounds":"3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H2O = 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + phosphate"}
{"X":54546,"RHEA_ID":56513,"compounds":"3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H2O => 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + phosphate"}
{"X":54547,"RHEA_ID":53179,"compounds":"H2O + N-acyl-1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine <=> 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)"}
{"X":54548,"RHEA_ID":53180,"compounds":"D-erythrose = D-erythrulose"}
{"X":54549,"RHEA_ID":59908,"compounds":"H2O + hexanal + NADP(+) = 2 H(+) + hexanoate + NADPH"}
{"X":54550,"RHEA_ID":56517,"DIRECTION":"LR","MASTER_ID":56516,"metacyc":"RXN-17519","compounds":"Fe-coproporphyrin III + 2 H(+) + 2 H2O2 => 2 CO2 + 4 H2O + heme b"}
{"X":54551,"RHEA_ID":53183,"compounds":"D-erythrose <=> D-erythrulose"}
{"X":54552,"RHEA_ID":59911,"compounds":"H2O + hexanal + NADP(+) <=> 2 H(+) + hexanoate + NADPH"}
{"X":54553,"RHEA_ID":59912,"compounds":"(E)-4-hydroxynon-2-enal + H2O + NADP(+) = (E)-4-hydroxynon-2-enoate + 2 H(+) + NADPH"}
{"X":54554,"RHEA_ID":57623,"compounds":"dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + ML-236C carboxylate + oxidized [NADPH--hemoprotein reductase]"}
{"X":54555,"RHEA_ID":53187,"compounds":"1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H2O <=> 1-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}
{"X":54556,"RHEA_ID":53188,"compounds":"1-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-9Z-octadecenoyl)-ethanolamine + H2O = 1-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine"}
{"X":54557,"RHEA_ID":56524,"compounds":"A + dihydro-heme d1 = AH2 + heme d1"}
{"X":54558,"RHEA_ID":61213,"compounds":"myricetin + UDP-alpha-D-glucose => H(+) + myricetin 3-O-beta-D-glucoside + UDP"}
{"X":54559,"RHEA_ID":53191,"compounds":"1-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-9Z-octadecenoyl)-ethanolamine + H2O <=> 1-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine"}
{"X":54560,"RHEA_ID":53192,"compounds":"1-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + H2O = 1-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine"}
{"X":54561,"RHEA_ID":56528,"DIRECTION":"UN","MASTER_ID":56528,"ec":"1.14.19.59","compounds":"chloride + D-tryptophan + FADH2 + O2 = 6-chloro-D-tryptophan + FAD + 2 H2O"}
{"X":54562,"RHEA_ID":53194,"compounds":"1-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine => 1-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + H2O"}
{"X":54563,"RHEA_ID":53195,"compounds":"1-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + H2O <=> 1-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine"}
{"X":54564,"RHEA_ID":53196,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 16alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54565,"RHEA_ID":56532,"compounds":"H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine phosphate = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + phosphate"}
{"X":54566,"RHEA_ID":61221,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-CDP + 1D-myo-inositol 3-phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)"}
{"X":54567,"RHEA_ID":53199,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 16alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54568,"RHEA_ID":53200,"compounds":"17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase] = 17beta,19-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54569,"RHEA_ID":54294,"compounds":"3-O-(5'-adenylyl)-L-threonyl-[protein] + diphosphate => ATP + L-threonyl-[protein]"}
{"X":54570,"RHEA_ID":53202,"compounds":"17beta,19-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":54571,"RHEA_ID":53203,"compounds":"17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 17beta,19-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54572,"RHEA_ID":53204,"compounds":"17beta,19-dihydroxy-3-oxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase] = 17beta-hydroxy-3,19-dioxo-5alpha-androstanone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54573,"RHEA_ID":56540,"compounds":"(9Z)-octadecenoyl-CoA + 1,2-dihexanoyl-sn-glycerol = 1,2-dihexanoyl-3-(9Z-octadecenoyl)-sn-glycerol + CoA"}
{"X":54574,"RHEA_ID":54299,"compounds":"GTP + L-tyrosyl-[protein] <=> diphosphate + O-(5'-guanylyl)-L-tyrosyl-[protein]"}
{"X":54575,"RHEA_ID":53207,"compounds":"17beta,19-dihydroxy-3-oxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase] <=> 17beta-hydroxy-3,19-dioxo-5alpha-androstanone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54576,"RHEA_ID":53208,"DIRECTION":"UN","MASTER_ID":53208,"ec":"1.14.14.90","compounds":"daidzein + O2 + reduced [NADPH--hemoprotein reductase] = 2'-hydroxydaidzein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54577,"RHEA_ID":59948,"compounds":"H2O + prostaglandin F2alpha-CoA = CoA + H(+) + prostaglandin F2alpha"}
{"X":54578,"RHEA_ID":57647,"compounds":"(3-{(1R,2S,6S,8R)-2,8-dimethyl-3-[(E)-prop-1-enyl]-4,5-didehydrodecalin-2-yl}-3-oxopropanoyl)-[equisetin nonaketide synthase] + L-serine <=> H(+) + H2O + holo-[equisetin nonaketide synthase] + trichosetin"}
{"X":54579,"RHEA_ID":56546,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => H2O + N-hexadecanoyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine"}
{"X":54580,"RHEA_ID":56547,"compounds":"H2O + N-hexadecanoyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}
{"X":54581,"RHEA_ID":56548,"compounds":"H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine"}
{"X":54582,"RHEA_ID":53214,"compounds":"17beta,18-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":54583,"RHEA_ID":53215,"compounds":"17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 17beta,18-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54584,"RHEA_ID":53216,"compounds":"17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha,17alpha-dihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54585,"RHEA_ID":59960,"compounds":"N(alpha)-acetyl-D-methionine = N(alpha)-acetyl-L-methionine"}
{"X":54586,"RHEA_ID":53218,"compounds":"16alpha,17alpha-dihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":54587,"RHEA_ID":53219,"compounds":"17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 16alpha,17alpha-dihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54588,"RHEA_ID":53220,"compounds":"16alpha,17alpha-dihydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] = 6beta,16alpha,17alpha-trihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54589,"RHEA_ID":59964,"compounds":"L-seryl-[protein] + octanoyl-CoA = CoA + O-octanoyl-L-seryl-[protein]"}
{"X":54590,"RHEA_ID":59965,"compounds":"L-seryl-[protein] + octanoyl-CoA => CoA + O-octanoyl-L-seryl-[protein]"}
{"X":54591,"RHEA_ID":53223,"compounds":"16alpha,17alpha-dihydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta,16alpha,17alpha-trihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54592,"RHEA_ID":53224,"compounds":"16alpha,17alpha-dihydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase] = 3beta,16alpha-dihydroxy-androst-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54593,"RHEA_ID":56560,"DIRECTION":"UN","MASTER_ID":56560,"ec":"2.4.1.186","compounds":"[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + H(+) + UDP"}
{"X":54594,"RHEA_ID":59969,"compounds":"L-threonyl-[protein] + octanoyl-CoA => CoA + O-octanoyl-L-threonyl-[protein]"}
{"X":54595,"RHEA_ID":56562,"compounds":"[1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + H(+) + UDP => [1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose"}
{"X":54596,"RHEA_ID":53228,"compounds":"androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54597,"RHEA_ID":59972,"compounds":"decanoyl-CoA + L-seryl-[protein] = CoA + O-decanoyl-L-seryl-[protein]"}
{"X":54598,"RHEA_ID":59973,"compounds":"decanoyl-CoA + L-seryl-[protein] => CoA + O-decanoyl-L-seryl-[protein]"}
{"X":54599,"RHEA_ID":53231,"compounds":"androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] <=> 16alpha-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54600,"RHEA_ID":53232,"compounds":"cholesta-5,24-dien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-25-epoxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54601,"RHEA_ID":53233,"compounds":"cholesta-5,24-dien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => (24S)-25-epoxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54602,"RHEA_ID":59977,"DIRECTION":"LR","MASTER_ID":59976,"metacyc":"RXN-20391","compounds":"2-phenylacetate + H(+) => CO2 + toluene"}
{"X":54603,"RHEA_ID":53235,"compounds":"cholesta-5,24-dien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S)-25-epoxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54604,"RHEA_ID":53236,"compounds":"cholesta-5,24-dien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = cholesta-5,24Z-dien-3beta,27-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54605,"RHEA_ID":59980,"DIRECTION":"UN","MASTER_ID":59980,"ec":"3.6.1.69","compounds":"8-oxo-dGTP + H2O = 8-oxo-dGDP + H(+) + phosphate"}
{"X":54606,"RHEA_ID":59981,"DIRECTION":"LR","MASTER_ID":59980,"metacyc":"RXN-20666","compounds":"8-oxo-dGTP + H2O => 8-oxo-dGDP + H(+) + phosphate"}
{"X":54607,"RHEA_ID":53239,"compounds":"cholesta-5,24-dien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> cholesta-5,24Z-dien-3beta,27-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54608,"RHEA_ID":56574,"compounds":"globoside Gb3Cer + H(+) + UDP => beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-alpha-D-galactose"}
{"X":54609,"RHEA_ID":56575,"compounds":"beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-alpha-D-galactose <=> globoside Gb3Cer + H(+) + UDP"}
{"X":54610,"RHEA_ID":53242,"compounds":"cholesta-5,7-dien-3beta,25-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesta-5,7-dien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":54611,"RHEA_ID":53243,"compounds":"cholesta-5,7-dien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> cholesta-5,7-dien-3beta,25-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54612,"RHEA_ID":59988,"DIRECTION":"UN","MASTER_ID":59988,"ec":"1.3.1.120","compounds":"cyclohexane-1-carbonyl-CoA + NADP(+) = cyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH"}
{"X":54613,"RHEA_ID":53246,"compounds":"cholesta-5,7-dien-3beta,24S-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesta-5,7-dien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":54614,"RHEA_ID":53247,"compounds":"cholesta-5,7-dien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> cholesta-5,7-dien-3beta,24S-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54615,"RHEA_ID":56582,"compounds":"6-methylthioguanine + H(+) + S-adenosyl-L-homocysteine => 6-thioguanine + S-adenosyl-L-methionine"}
{"X":54616,"RHEA_ID":54350,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+) => 1-O-hexadecyl-2-acetyl-sn-glycerol + CDP-choline"}
{"X":54617,"RHEA_ID":54351,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycerol + CDP-choline <=> 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+)"}
{"X":54618,"RHEA_ID":53251,"compounds":"cholesta-5,7-dien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta-hydroxycholest-5-en-7-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54619,"RHEA_ID":53252,"compounds":"5alpha-cholest-7-en-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = 5alpha-cholestan-7-oxo-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54620,"RHEA_ID":56587,"compounds":"1,2-epoxypropane + H2O <=> propane-1,2-diol"}
{"X":54621,"RHEA_ID":61277,"compounds":"H2O + L-ornithine + O2 => 5-amino-2-oxopentanoate + H2O2 + NH4(+)"}
{"X":54622,"RHEA_ID":53255,"compounds":"5alpha-cholest-7-en-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> 5alpha-cholestan-7-oxo-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54623,"RHEA_ID":53256,"compounds":"5alpha-cholest-7-en-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha,8alpha-epoxy-5alpha-cholestan-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54624,"RHEA_ID":53257,"compounds":"5alpha-cholest-7-en-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => 7alpha,8alpha-epoxy-5alpha-cholestan-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54625,"RHEA_ID":61281,"compounds":"4-aminobutanoate + H2O + O2 => H2O2 + NH4(+) + succinate semialdehyde"}
{"X":54626,"RHEA_ID":53259,"compounds":"5alpha-cholest-7-en-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> 7alpha,8alpha-epoxy-5alpha-cholestan-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54627,"RHEA_ID":53260,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 1beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54628,"RHEA_ID":60004,"compounds":"(L-glutamyl)n+1-L-gamma-glutamyl-L-glutamyl-[protein] + H2O = (L-glutamyl)n-L-gamma-glutamyl-L-glutamyl-[protein] + L-glutamate"}
{"X":54629,"RHEA_ID":53262,"compounds":"1beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone"}
{"X":54630,"RHEA_ID":60006,"compounds":"(L-glutamyl)n-L-gamma-glutamyl-L-glutamyl-[protein] + L-glutamate => (L-glutamyl)n+1-L-gamma-glutamyl-L-glutamyl-[protein] + H2O"}
{"X":54631,"RHEA_ID":56598,"compounds":"(1S,4S)-5-oxo-1,2-campholide + FMN + H(+) + H2O => (1S,4S)-bornane-2,5-dione + FMNH2 + O2"}
{"X":54632,"RHEA_ID":60008,"compounds":"a tRNA precursor + 2 CTP = a tRNA with a 3' CC end + 2 diphosphate"}
{"X":54633,"RHEA_ID":53266,"compounds":"2beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone"}
{"X":54634,"RHEA_ID":60010,"compounds":"a tRNA with a 3' CC end + 2 diphosphate => a tRNA precursor + 2 CTP"}
{"X":54635,"RHEA_ID":53268,"DIRECTION":"UN","MASTER_ID":53268,"ec":"5.1.3.31","compounds":"L-ribulose = L-xylulose"}
{"X":54636,"RHEA_ID":56603,"compounds":"3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-threonyl-[EGF-like domain protein] + UDP-alpha-D-xylose <=> 3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-threonyl-[EGF-like domain protein] + H(+) + UDP"}
{"X":54637,"RHEA_ID":53270,"compounds":"L-xylulose => L-ribulose"}
{"X":54638,"RHEA_ID":60014,"compounds":"a tRNA with a 3' CCA end + diphosphate => a tRNA with a 3' CC end + ATP"}
{"X":54639,"RHEA_ID":53272,"compounds":"5-dehydro-L-gluconate = keto-D-tagaturonate"}
{"X":54640,"RHEA_ID":56607,"compounds":"3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) <=> 6-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)"}
{"X":54641,"RHEA_ID":53274,"compounds":"keto-D-tagaturonate => 5-dehydro-L-gluconate"}
{"X":54642,"RHEA_ID":60018,"compounds":"diphosphate + sesquisabinene B => (2E,6E)-farnesyl diphosphate"}
{"X":54643,"RHEA_ID":53276,"compounds":"17beta-hydroxy-3,19-dioxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase] = 17beta-hydroxy-3-oxo-19-nor-5alpha-androst-1-ene + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54644,"RHEA_ID":56611,"compounds":"5,10-methylenetetrahydrosulfopterin + glycine + H2O <=> L-serine + tetrahydrosulfopterin"}
{"X":54645,"RHEA_ID":53278,"compounds":"17beta-hydroxy-3-oxo-19-nor-5alpha-androst-1-ene + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-hydroxy-3,19-dioxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":54646,"RHEA_ID":53279,"compounds":"17beta-hydroxy-3,19-dioxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase] <=> 17beta-hydroxy-3-oxo-19-nor-5alpha-androst-1-ene + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54647,"RHEA_ID":53280,"compounds":"D-threose = D-erythrulose"}
{"X":54648,"RHEA_ID":57726,"compounds":"CO2 + 2 Na(+)(out) + pyruvate => H(+) + 2 Na(+)(in) + oxaloacetate"}
{"X":54649,"RHEA_ID":53282,"compounds":"D-erythrulose => D-threose"}
{"X":54650,"RHEA_ID":56617,"DIRECTION":"LR","MASTER_ID":56616,"metacyc":"LINABSPON-RXN","compounds":"(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene => 1,2,4-trichlorobenzene + chloride + H(+)"}
{"X":54651,"RHEA_ID":53284,"compounds":"NAD(+) + scyllo-inosose = 3-dehydro-scyllo-inosose + H(+) + NADH"}
{"X":54652,"RHEA_ID":60028,"compounds":"(2E)-geranyl diphosphate + H2O = 4-terpineol + diphosphate"}
{"X":54653,"RHEA_ID":53286,"compounds":"3-dehydro-scyllo-inosose + H(+) + NADH => NAD(+) + scyllo-inosose"}
{"X":54654,"RHEA_ID":56621,"DIRECTION":"LR","MASTER_ID":56620,"metacyc":"LINB1-RXN","compounds":"(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + H2O => 2,4,5-trichlorocyclohexa-2,5-dien-1-ol + chloride + H(+)"}
{"X":54655,"RHEA_ID":53288,"compounds":"3-dehydro-scyllo-inosose + H2O = 5-dehydro-L-gluconate + H(+)"}
{"X":54656,"RHEA_ID":60032,"DIRECTION":"UN","MASTER_ID":60032,"ec":"3.6.1.69","compounds":"8-oxo-GTP + H2O = 8-oxo-GDP + H(+) + phosphate"}
{"X":54657,"RHEA_ID":60033,"compounds":"8-oxo-GTP + H2O => 8-oxo-GDP + H(+) + phosphate"}
{"X":54658,"RHEA_ID":61314,"compounds":"germacra-1(10),4,11(13)-trien-12-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-ol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":54659,"RHEA_ID":53292,"compounds":"H2O + L-5-[2-(methysulfanyl)ethyl]hydantoin = H(+) + N-carbamoyl-L-methionine"}
{"X":54660,"RHEA_ID":53293,"compounds":"H2O + L-5-[2-(methysulfanyl)ethyl]hydantoin => H(+) + N-carbamoyl-L-methionine"}
{"X":54661,"RHEA_ID":56628,"compounds":"5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H2O = chloride + 2 H(+) + maleylacetate"}
{"X":54662,"RHEA_ID":53295,"compounds":"H2O + L-5-[2-(methysulfanyl)ethyl]hydantoin <=> H(+) + N-carbamoyl-L-methionine"}
{"X":54663,"RHEA_ID":53296,"compounds":"(2E)-decenoyl-CoA + NADP(+) = (2E,4E)-decadienoyl-CoA + H(+) + NADPH"}
{"X":54664,"RHEA_ID":56631,"compounds":"5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H2O <=> chloride + 2 H(+) + maleylacetate"}
{"X":54665,"RHEA_ID":56632,"compounds":"H2O + neryl diphosphate = 1,8-cineole + diphosphate"}
{"X":54666,"RHEA_ID":57744,"DIRECTION":"UN","MASTER_ID":57744,"ec":"1.17.4.4","compounds":"[protein]-disulfide + phylloquinol = [protein]-dithiol + phylloquinone"}
{"X":54667,"RHEA_ID":53300,"compounds":"D-5-[2-(methylsulfanyl)ethyl]hydantoin + H2O = H(+) + N-carbamoyl-D-methionine"}
{"X":54668,"RHEA_ID":56635,"compounds":"H2O + neryl diphosphate <=> 1,8-cineole + diphosphate"}
{"X":54669,"RHEA_ID":53302,"compounds":"H(+) + N-carbamoyl-D-methionine => D-5-[2-(methylsulfanyl)ethyl]hydantoin + H2O"}
{"X":54670,"RHEA_ID":61326,"compounds":"3beta-hydroxycostunolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":54671,"RHEA_ID":53304,"compounds":"AH2 + 2 ATP + 2 cob(II)alamin = A + 2 adenosylcob(III)alamin + 2 H(+) + 2 triphosphate"}
{"X":54672,"RHEA_ID":56639,"compounds":"1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O <=> 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate"}
{"X":54673,"RHEA_ID":54407,"compounds":"1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O <=> 2-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate"}
{"X":54674,"RHEA_ID":53307,"compounds":"AH2 + 2 ATP + 2 cob(II)alamin <=> A + 2 adenosylcob(III)alamin + 2 H(+) + 2 triphosphate"}
{"X":54675,"RHEA_ID":53308,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54676,"RHEA_ID":56643,"compounds":"1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z)-octadecadienoate + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+)"}
{"X":54677,"RHEA_ID":56644,"compounds":"a uridine in mRNA = a pseudouridine in mRNA"}
{"X":54678,"RHEA_ID":53311,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54679,"RHEA_ID":53312,"compounds":"(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 16(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54680,"RHEA_ID":57758,"compounds":"C35-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+) => 2 (S)-methylmalonyl-CoA + 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH"}
{"X":54681,"RHEA_ID":54415,"compounds":"a 3-oxo-5beta-steroid + NADP(+) <=> a 3-oxo-Delta(4)-steroid + H(+) + NADPH"}
{"X":54682,"RHEA_ID":61338,"compounds":"ADP + H(+) + phosphate + protoporphyrin IX(out) => ATP + H2O + protoporphyrin IX(in)"}
{"X":54683,"RHEA_ID":53316,"DIRECTION":"UN","MASTER_ID":53316,"ec":"2.4.1.348","compounds":"GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol = alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,poly-cis-undecaprenol + GDP + H(+)"}
{"X":54684,"RHEA_ID":56650,"DIRECTION":"RL","MASTER_ID":56648,"metacyc":"RXN-17402","compounds":"3-oxochol-4,6-dien-24-oyl-CoA + H(+) + NADH => 3-oxochol-4-en-24-oyl-CoA + NAD(+)"}
{"X":54685,"RHEA_ID":55522,"compounds":"3 diphosphate + nerylneryl diphosphate => dimethylallyl diphosphate + 3 isopentenyl diphosphate"}
{"X":54686,"RHEA_ID":57764,"DIRECTION":"UN","MASTER_ID":57764,"ec":"1.14.12.23","compounds":"2,6-dinitrotoluene + NADH + O2 = 3-methyl-4-nitrocatechol + NAD(+) + nitrite"}
{"X":54687,"RHEA_ID":53320,"DIRECTION":"UN","MASTER_ID":53320,"ec":"2.4.1.349","compounds":"alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,poly-cis-undecaprenol + 2 GDP-alpha-D-mannose = alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,polycis-undecaprenol + 2 GDP + 2 H(+)"}
{"X":54688,"RHEA_ID":53321,"compounds":"alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,poly-cis-undecaprenol + 2 GDP-alpha-D-mannose => alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,polycis-undecaprenol + 2 GDP + 2 H(+)"}
{"X":54689,"RHEA_ID":56656,"DIRECTION":"UN","MASTER_ID":56656,"ec":"1.3.1.114","compounds":"12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NAD(+) = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H(+) + NADH"}
{"X":54690,"RHEA_ID":54424,"compounds":"L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide"}
{"X":54691,"RHEA_ID":53324,"compounds":"2-glyceryl-prostaglandin H2 = 2-glyceryl-prostaglandin E2"}
{"X":54692,"RHEA_ID":53326,"compounds":"2-glyceryl-prostaglandin E2 => 2-glyceryl-prostaglandin H2"}
{"X":54693,"RHEA_ID":56661,"DIRECTION":"LR","MASTER_ID":56660,"metacyc":"RXN-17400","compounds":"7alpha-hydroxy-3-oxochol-24-oyl-CoA + NAD(+) => 7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH"}
{"X":54694,"RHEA_ID":53328,"compounds":"H2O + UDP-2,3-diacyl-alpha-D-glucosamine = 2,3-diacyl-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP"}
{"X":54695,"RHEA_ID":53329,"compounds":"H2O + UDP-2,3-diacyl-alpha-D-glucosamine => 2,3-diacyl-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP"}
{"X":54696,"RHEA_ID":56664,"DIRECTION":"UN","MASTER_ID":56664,"ec":"1.3.1.115","compounds":"7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + NAD(+) = 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH"}
{"X":54697,"RHEA_ID":54432,"DIRECTION":"UN","MASTER_ID":54432,"ec":"1.14.20.4","compounds":"2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2 = a 4-H-anthocyanidin with a 3-hydroxy group + CO2 + 2 H2O + succinate"}
{"X":54698,"RHEA_ID":53332,"compounds":"2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 = 2-[15(S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-glycerol"}
{"X":54699,"RHEA_ID":53333,"compounds":"2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 => 2-[15(S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-glycerol"}
{"X":54700,"RHEA_ID":54435,"compounds":"2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2 <=> a 4-H-anthocyanidin with a 3-hydroxy group + CO2 + 2 H2O + succinate"}
{"X":54701,"RHEA_ID":57780,"DIRECTION":"UN","MASTER_ID":57780,"ec":"1.14.12.23","metacyc":"RXN-16802","compounds":"2-chloro-4-nitrotoluene + NADH + O2 = 3-chloro-4-methylcatechol + NAD(+) + nitrite"}
{"X":54702,"RHEA_ID":53336,"DIRECTION":"UN","MASTER_ID":53336,"ec":"1.3.1.91","compounds":"5,6-dihydrouridine(20) in tRNA + NADP(+) = H(+) + NADPH + uridine(20) in tRNA"}
{"X":54703,"RHEA_ID":56671,"compounds":"7beta-hydroxy-3-oxochol-24-oyl-CoA + NAD(+) <=> 7beta-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH"}
{"X":54704,"RHEA_ID":53338,"DIRECTION":"RL","MASTER_ID":53336,"metacyc":"RXN-12456","compounds":"H(+) + NADPH + uridine(20) in tRNA => 5,6-dihydrouridine(20) in tRNA + NADP(+)"}
{"X":54705,"RHEA_ID":56673,"compounds":"dihydro-4-coumaroyl-CoA + NADP(+) => (E)-4-coumaroyl-CoA + H(+) + NADPH"}
{"X":54706,"RHEA_ID":53340,"DIRECTION":"UN","MASTER_ID":53340,"ec":"1.3.1.91","compounds":"5,6-dihydrouridine(20) in tRNA + NAD(+) = H(+) + NADH + uridine(20) in tRNA"}
{"X":54707,"RHEA_ID":53341,"compounds":"5,6-dihydrouridine(20) in tRNA + NAD(+) => H(+) + NADH + uridine(20) in tRNA"}
{"X":54708,"RHEA_ID":53342,"DIRECTION":"RL","MASTER_ID":53340,"metacyc":"RXN-12456","compounds":"H(+) + NADH + uridine(20) in tRNA => 5,6-dihydrouridine(20) in tRNA + NAD(+)"}
{"X":54709,"RHEA_ID":60085,"DIRECTION":"LR","MASTER_ID":60084,"metacyc":"RXN-20109","compounds":"a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NAD(+) => a 4alpha-methyl-3-oxosteroid + CO2 + NADH"}
{"X":54710,"RHEA_ID":53344,"DIRECTION":"UN","MASTER_ID":53344,"ec":"1.3.1.90","compounds":"5,6-dihydrouridine(20a) in tRNA + NADP(+) = H(+) + NADPH + uridine(20a) in tRNA"}
{"X":54711,"RHEA_ID":53345,"compounds":"5,6-dihydrouridine(20a) in tRNA + NADP(+) => H(+) + NADPH + uridine(20a) in tRNA"}
{"X":54712,"RHEA_ID":53346,"DIRECTION":"RL","MASTER_ID":53344,"metacyc":"RXN-12475","compounds":"H(+) + NADPH + uridine(20a) in tRNA => 5,6-dihydrouridine(20a) in tRNA + NADP(+)"}
{"X":54713,"RHEA_ID":56681,"DIRECTION":"LR","MASTER_ID":56680,"metacyc":"RXN-16853","compounds":"beta-dihydromenaquinone-9 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":54714,"RHEA_ID":56682,"compounds":"H2O + omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized [2Fe-2S]-[ferredoxin] => beta-dihydromenaquinone-9 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":54715,"RHEA_ID":53349,"compounds":"5,6-dihydrouridine(20a) in tRNA + NAD(+) => H(+) + NADH + uridine(20a) in tRNA"}
{"X":54716,"RHEA_ID":56684,"DIRECTION":"UN","MASTER_ID":56684,"ec":"1.14.19.61","compounds":"dihydrorhizobitoxine + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + rhizobitoxine"}
{"X":54717,"RHEA_ID":60093,"DIRECTION":"LR","MASTER_ID":60092,"metacyc":"RXN-20116","compounds":"4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+) => 4alpha-methyl-5alpha-cholesta-8,24-dien-3-one + CO2 + NADH"}
{"X":54718,"RHEA_ID":57797,"compounds":"4-nitrotoluene + NADH + O2 => 4-methylcatechol + NAD(+) + nitrite"}
{"X":54719,"RHEA_ID":60095,"compounds":"4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+) <=> 4alpha-methyl-5alpha-cholesta-8,24-dien-3-one + CO2 + NADH"}
{"X":54720,"RHEA_ID":56688,"DIRECTION":"UN","MASTER_ID":56688,"ec":"1.14.20.9","compounds":"(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + O2 = (2E)-3-(4-hydroxyphenyl)-2-isocyanoprop-2-enoate + CO2 + H2O + succinate"}
{"X":54721,"RHEA_ID":60097,"DIRECTION":"LR","MASTER_ID":60096,"metacyc":"RXN-20116","compounds":"4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) => 4alpha-methyl-5alpha-cholesta-8,24-dien-3-one + CO2 + NADPH"}
{"X":54722,"RHEA_ID":54457,"compounds":"1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O => 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate"}
{"X":54723,"RHEA_ID":60099,"compounds":"4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) <=> 4alpha-methyl-5alpha-cholesta-8,24-dien-3-one + CO2 + NADPH"}
{"X":54724,"RHEA_ID":56692,"DIRECTION":"UN","MASTER_ID":56692,"ec":"1.14.20.10","compounds":"(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 = 4-[(E)-2-isocyanoethenyl]phenol + 2 CO2 + H2O + succinate"}
{"X":54725,"RHEA_ID":60101,"DIRECTION":"LR","MASTER_ID":60100,"metacyc":"RXN1F-775","compounds":"cyanidin + UDP-alpha-D-glucose => cyanidin 3-O-beta-D-glucoside + H(+) + UDP"}
{"X":54726,"RHEA_ID":53360,"DIRECTION":"UN","MASTER_ID":53360,"ec":"1.3.1.89","compounds":"5,6-dihydrouridine(47) in tRNA + NADP(+) = H(+) + NADPH + uridine(47) in tRNA"}
{"X":54727,"RHEA_ID":57806,"compounds":"4-chlorocatechol + NAD(+) + nitrite => 1-chloro-3-nitrobenzene + NADH + O2"}
{"X":54728,"RHEA_ID":56696,"DIRECTION":"UN","MASTER_ID":56696,"ec":"4.1.99.25","compounds":"D-ribulose 5-phosphate + L-tryptophan = (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate"}
{"X":54729,"RHEA_ID":60105,"compounds":"3-(1H-indol-3-yl)propanoate + H(+) + oxidized [electron-transfer flavoprotein] => (E)-3-(indol-3-yl)acrylate + reduced [electron-transfer flavoprotein]"}
{"X":54730,"RHEA_ID":53364,"DIRECTION":"UN","MASTER_ID":53364,"ec":"1.3.1.89","compounds":"5,6-dihydrouridine(47) in tRNA + NAD(+) = H(+) + NADH + uridine(47) in tRNA"}
{"X":54731,"RHEA_ID":53365,"compounds":"5,6-dihydrouridine(47) in tRNA + NAD(+) => H(+) + NADH + uridine(47) in tRNA"}
{"X":54732,"RHEA_ID":53366,"DIRECTION":"RL","MASTER_ID":53364,"metacyc":"RXN-12457","compounds":"H(+) + NADH + uridine(47) in tRNA => 5,6-dihydrouridine(47) in tRNA + NAD(+)"}
{"X":54733,"RHEA_ID":53367,"compounds":"5,6-dihydrouridine(47) in tRNA + NAD(+) <=> H(+) + NADH + uridine(47) in tRNA"}
{"X":54734,"RHEA_ID":57813,"DIRECTION":"LR","MASTER_ID":57812,"metacyc":"RXN-16792","compounds":"1-chloro-2-nitrobenzene + NADH + O2 => 3-chlorocatechol + NAD(+) + nitrite"}
{"X":54735,"RHEA_ID":53369,"compounds":"5,6-dihydrouridine(17) in tRNA + NADP(+) => H(+) + NADPH + uridine(17) in tRNA"}
{"X":54736,"RHEA_ID":53370,"DIRECTION":"RL","MASTER_ID":53368,"metacyc":"RXN-12455","compounds":"H(+) + NADPH + uridine(17) in tRNA => 5,6-dihydrouridine(17) in tRNA + NADP(+)"}
{"X":54737,"RHEA_ID":56705,"DIRECTION":"LR","MASTER_ID":56704,"metacyc":"RXN-19265","compounds":"(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 => 3-[(E)-2-isocyanovinyl]indole + 2 CO2 + H2O + succinate"}
{"X":54738,"RHEA_ID":54473,"compounds":"1-octadecanoyl-2-nonanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanoate"}
{"X":54739,"RHEA_ID":54474,"compounds":"1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanoate => 1-octadecanoyl-2-nonanoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":54740,"RHEA_ID":53374,"DIRECTION":"RL","MASTER_ID":53372,"metacyc":"RXN-12455","compounds":"H(+) + NADH + uridine(17) in tRNA => 5,6-dihydrouridine(17) in tRNA + NAD(+)"}
{"X":54741,"RHEA_ID":61398,"compounds":"ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein] => ATP + N(6)-(D-erythrulosyl)-L-lysyl-[protein]"}
{"X":54742,"RHEA_ID":60116,"DIRECTION":"UN","MASTER_ID":60116,"ec":"1.14.11.71","compounds":"2-oxoglutarate + methylphosphonate + O2 = CO2 + hydroxymethylphosphonate + succinate"}
{"X":54743,"RHEA_ID":53377,"compounds":"5,6-dihydrouridine(16) in tRNA + NADP(+) => H(+) + NADPH + uridine(16) in tRNA"}
{"X":54744,"RHEA_ID":54479,"compounds":"1-octadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + dodecanoate + H(+)"}
{"X":54745,"RHEA_ID":61402,"compounds":"ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysine => ATP + N(6)-(D-ribulosyl)-L-lysine"}
{"X":54746,"RHEA_ID":57825,"compounds":"dAMP + H2O => 2-deoxy-D-ribose 5-phosphate + adenine"}
{"X":54747,"RHEA_ID":56715,"compounds":"1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] <=> H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate"}
{"X":54748,"RHEA_ID":53382,"DIRECTION":"RL","MASTER_ID":53380,"metacyc":"RXN-12454","compounds":"H(+) + NADH + uridine(16) in tRNA => 5,6-dihydrouridine(16) in tRNA + NAD(+)"}
{"X":54749,"RHEA_ID":60125,"DIRECTION":"LR","MASTER_ID":60124,"metacyc":"RXN-20719","compounds":"pre-sodorifen diphosphate => diphosphate + sodorifen"}
{"X":54750,"RHEA_ID":60124,"DIRECTION":"UN","MASTER_ID":60124,"ec":"4.2.3.205","compounds":"pre-sodorifen diphosphate = diphosphate + sodorifen"}
{"X":54751,"RHEA_ID":53385,"compounds":"5,10-methylenetetrahydromethanopterin + NAD(+) => 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADH"}
{"X":54752,"RHEA_ID":56720,"DIRECTION":"UN","MASTER_ID":56720,"ec":"2.8.5.2","compounds":"2 [Fe(III)cytochrome c] + L-cysteinyl-[SoxY protein] + thiosulfate = 2 [Fe(II)cytochrome c] + 2 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]"}
{"X":54753,"RHEA_ID":61410,"compounds":"ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysine => ATP + N(6)-(D-erythrulosyl)-L-lysine"}
{"X":54754,"RHEA_ID":57085,"compounds":"a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O => a fatty acid + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+)"}
{"X":54755,"RHEA_ID":53389,"compounds":"5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + UDP-alpha-D-glucuronate => 5alpha-dihydrotestosterone 17-O-[beta-D-glucuronosyl-(1->2)-glucuronate] + H(+) + UDP"}
{"X":54756,"RHEA_ID":53390,"compounds":"5alpha-dihydrotestosterone 17-O-[beta-D-glucuronosyl-(1->2)-glucuronate] + H(+) + UDP => 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + UDP-alpha-D-glucuronate"}
{"X":54757,"RHEA_ID":56724,"compounds":"AH2 + all-trans-beta-carotene + O2 = 4-hydroxy-all-trans-beta-carotene + A + H2O"}
{"X":54758,"RHEA_ID":57837,"compounds":"H2O + O2 + thermospermine => 3-aminopropanal + H2O2 + spermidine"}
{"X":54759,"RHEA_ID":53393,"DIRECTION":"LR","MASTER_ID":53392,"metacyc":"RXN-12489","compounds":"2-phenylacetate + O2 + reduced [NADPH--hemoprotein reductase] => (2-hydroxyphenyl)acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54760,"RHEA_ID":53394,"compounds":"(2-hydroxyphenyl)acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 2-phenylacetate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":54761,"RHEA_ID":61418,"compounds":"cis-trans-nepetalactol => (S)-8-oxocitronellyl enol"}
{"X":54762,"RHEA_ID":58952,"DIRECTION":"UN","MASTER_ID":58952,"ec":"2.4.1.367","compounds":"(20S)-protopanaxatriol + UDP-alpha-D-glucose = (20S)-ginsenoside Rh1 + H(+) + UDP"}
{"X":54763,"RHEA_ID":57841,"DIRECTION":"LR","MASTER_ID":57840,"reactome":"R-HSA-6809565.2","compounds":"1D-myo-inositol 1,3-bisphosphate + H2O => 1D-myo-inositol 1-phosphate + phosphate"}
{"X":54764,"RHEA_ID":53398,"compounds":"3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + dolichyl phosphate + H(+) => dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein]"}
{"X":54765,"RHEA_ID":60141,"compounds":"dodecanoyl-CoA + H(+) + malonyl-CoA => 3-oxotetradecanoyl-CoA + CO2 + CoA"}
{"X":54766,"RHEA_ID":53400,"compounds":"(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = (13S)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate"}
{"X":54767,"RHEA_ID":56735,"compounds":"4,4-dihydroxy-all-trans-beta-carotene <=> echinenone + H2O"}
{"X":54768,"RHEA_ID":53402,"compounds":"(13S)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate"}
{"X":54769,"RHEA_ID":56737,"compounds":"H2O + O2 + retinal => H(+) + H2O2 + retinoate"}
{"X":54770,"RHEA_ID":57848,"DIRECTION":"UN","MASTER_ID":57848,"ec":"1.14.11.60","compounds":"2-oxoglutarate + O2 + scopoletin = CO2 + fraxetin + succinate"}
{"X":54771,"RHEA_ID":53405,"compounds":"(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => 13-hydroxy-(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate"}
{"X":54772,"RHEA_ID":56740,"compounds":"globoside Gb3Cer + UDP-alpha-D-galactose = GalGb3Cer + H(+) + UDP"}
{"X":54773,"RHEA_ID":60149,"compounds":"(L-glutamyl)n-L-gamma-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate => (L-glutamyl)n+1-L-gamma-glutamyl-L-glutamyl-[protein] + ADP + H(+) + phosphate"}
{"X":54774,"RHEA_ID":57852,"compounds":"a pyrimidine 2'-deoxyribonucleoside 5'-phosphate + H2O = 2-deoxy-D-ribose 5-phosphate + a pyrimidine nucleobase"}
{"X":54775,"RHEA_ID":56743,"compounds":"globoside Gb3Cer + UDP-alpha-D-galactose <=> GalGb3Cer + H(+) + UDP"}
{"X":54776,"RHEA_ID":53410,"compounds":"(4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+) => (1S,4R)-1-hydroxylimonen-2-one + H(+) + NADPH + O2"}
{"X":54777,"RHEA_ID":56745,"DIRECTION":"LR","MASTER_ID":56744,"metacyc":"RXN-20590","compounds":"2-oxoglutarate + L-arginyl-[protein] + O2 => (3R)-3-hydroxy-L-arginyl-[protein] + CO2 + succinate"}
{"X":54778,"RHEA_ID":61435,"compounds":"(R)-8-oxocitronellyl enol + NADP(+) <=> (6E)-8-oxogeranial + H(+) + NADPH"}
{"X":54779,"RHEA_ID":57857,"DIRECTION":"LR","MASTER_ID":57856,"metacyc":"RXN-12349","compounds":"(E)-feruloyl-CoA + 2-oxoglutarate + O2 => (E)-6-hydroxyferuloyl-CoA + CO2 + succinate"}
{"X":54780,"RHEA_ID":60155,"compounds":"H2O + L-gamma-glutamyl-L-glutamyl-[protein] <=> L-glutamate + L-glutamyl-[protein]"}
{"X":54781,"RHEA_ID":60157,"DIRECTION":"LR","MASTER_ID":60156,"ecocyc":"ABC-18-RXN","compounds":"ATP + D-galactose(out) + H2O => ADP + D-galactose(in) + H(+) + phosphate"}
{"X":54782,"RHEA_ID":60158,"compounds":"ADP + D-galactose(in) + H(+) + phosphate => ATP + D-galactose(out) + H2O"}
{"X":54783,"RHEA_ID":56751,"compounds":"an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an omega-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54784,"RHEA_ID":53418,"compounds":"8-demethyl-8-(methylamino)riboflavin + H(+) + S-adenosyl-L-homocysteine => 8-amino-8-demethylriboflavin + S-adenosyl-L-methionine"}
{"X":54785,"RHEA_ID":60161,"compounds":"ATP + H2O + vincristine(in) => ADP + H(+) + phosphate + vincristine(out)"}
{"X":54786,"RHEA_ID":60162,"compounds":"ADP + H(+) + phosphate + vincristine(out) => ATP + H2O + vincristine(in)"}
{"X":54787,"RHEA_ID":60163,"compounds":"ATP + H2O + vincristine(in) <=> ADP + H(+) + phosphate + vincristine(out)"}
{"X":54788,"RHEA_ID":53422,"compounds":"H(+) + roseoflavin + S-adenosyl-L-homocysteine => 8-demethyl-8-(methylamino)riboflavin + S-adenosyl-L-methionine"}
{"X":54789,"RHEA_ID":56757,"compounds":"5 H(+) + 3 O2 + obtusifoliol + 6 reduced [2Fe-2S]-[ferredoxin] => 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":54790,"RHEA_ID":60165,"compounds":"a guanosine in RNA + S-adenosyl-L-methionine => an N(7)-methylguanosine in RNA + S-adenosyl-L-homocysteine"}
{"X":54791,"RHEA_ID":54526,"compounds":"3-hydroxyhexane-2,5-dione + CO2 => acetoacetate + H(+) + methylglyoxal"}
{"X":54792,"RHEA_ID":53426,"compounds":"CoA + H(+) + N-acyl-sphingoid base => a sphingoid base + an acyl-CoA"}
{"X":54793,"RHEA_ID":53427,"compounds":"a sphingoid base + an acyl-CoA <=> CoA + H(+) + N-acyl-sphingoid base"}
{"X":54794,"RHEA_ID":60182,"compounds":"ADP + D-fructose(in) + H(+) + phosphate => ATP + D-fructose(out) + H2O"}
{"X":54795,"RHEA_ID":56763,"compounds":"24,25-dihydrolanosterol + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":54796,"RHEA_ID":53430,"compounds":"a thymidine in DNA + S-methyl-L-cysteinyl-[protein] => a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein]"}
{"X":54797,"RHEA_ID":60185,"DIRECTION":"LR","MASTER_ID":60184,"metacyc":"TRANS-RXN-320","compounds":"ATP + D-glucose(out) + H2O => ADP + D-glucose(in) + H(+) + phosphate"}
{"X":54798,"RHEA_ID":60186,"compounds":"ADP + D-glucose(in) + H(+) + phosphate => ATP + D-glucose(out) + H2O"}
{"X":54799,"RHEA_ID":57129,"compounds":"H2O + 2 oxidized [azurin] + tyramine => (4-hydroxyphenyl)acetaldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin]"}
{"X":54800,"RHEA_ID":61457,"compounds":"7-chlorotetracycline + H(+) + NADPH + O2 => (1S,10S,10aS)-3-(CONH2)-9-Cl-1-(Me2N)-3,3a,4,10-(HO)4-10-Me-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracen-6-olate + CO + H2O + NADP(+)"}
{"X":54801,"RHEA_ID":60189,"DIRECTION":"LR","MASTER_ID":60188,"metacyc":"RXN-20641","compounds":"2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 O2 => 2 CO2 + 2 formaldehyde + L-lysyl(9)-[histone H3] + 2 succinate"}
{"X":54802,"RHEA_ID":60190,"compounds":"2 CO2 + 2 formaldehyde + L-lysyl(9)-[histone H3] + 2 succinate => 2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 O2"}
{"X":54803,"RHEA_ID":57881,"DIRECTION":"LR","MASTER_ID":57880,"metacyc":"RXN-19402","compounds":"3-O-[(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-threonyl-[protein] + UDP-alpha-D-xylose => 3-O-[beta-D-xylosyl-(1->4)-(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-threonyl-[protein] + H(+) + UDP"}
{"X":54804,"RHEA_ID":53438,"compounds":"19-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":54805,"RHEA_ID":53439,"compounds":"leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54806,"RHEA_ID":53440,"compounds":"leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54807,"RHEA_ID":60195,"compounds":"2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + succinate"}
{"X":54808,"RHEA_ID":53442,"compounds":"18-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":54809,"RHEA_ID":56777,"DIRECTION":"LR","MASTER_ID":56776,"metacyc":"RXN-8695","compounds":"(+)-pinoresinol + O2 + reduced [NADPH--hemoprotein reductase] => (+)-piperitol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54810,"RHEA_ID":59000,"compounds":"H2O + O2 + propanal = H(+) + H2O2 + propanoate"}
{"X":54811,"RHEA_ID":56779,"compounds":"(+)-pinoresinol + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-piperitol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54812,"RHEA_ID":54547,"compounds":"1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine + 2-heptanoyl-sn-glycero-3-phosphocholine <=> 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine + hexanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":54813,"RHEA_ID":60201,"DIRECTION":"LR","MASTER_ID":60200,"metacyc":"RXN-20642","compounds":"2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2 => 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate"}
{"X":54814,"RHEA_ID":53448,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate"}
{"X":54815,"RHEA_ID":56783,"compounds":"(+)-piperitol + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-sesamin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54816,"RHEA_ID":56784,"DIRECTION":"UN","MASTER_ID":56784,"ec":"3.4.19.9","compounds":"(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n + (n-1) H2O = (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate"}
{"X":54817,"RHEA_ID":57895,"compounds":"a quinone + 5 H(+)(in) + NADPH <=> a quinol + 4 H(+)(out) + NADP(+)"}
{"X":54818,"RHEA_ID":53452,"compounds":"1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + a cholesterol ester"}
{"X":54819,"RHEA_ID":53454,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + a cholesterol ester => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + cholesterol"}
{"X":54820,"RHEA_ID":56789,"DIRECTION":"LR","MASTER_ID":56788,"ecocyc":"RXN-19340","metacyc":"RXN-19340","compounds":"apo-[corrinoid adenosyltransferase] + cob(II)alamin => cob(II)alamin--[corrinoid adenosyltransferase]"}
{"X":54821,"RHEA_ID":53456,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z-octadecenoate)"}
{"X":54822,"RHEA_ID":56790,"compounds":"cob(II)alamin--[corrinoid adenosyltransferase] => apo-[corrinoid adenosyltransferase] + cob(II)alamin"}
{"X":54823,"RHEA_ID":56792,"compounds":"2 cob(II)alamin--[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] = 2 [corrinoid adenosyltransferase]-cob(I)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":54824,"RHEA_ID":56793,"DIRECTION":"LR","MASTER_ID":56792,"ecocyc":"RXN-19334","metacyc":"RXN-19334","compounds":"2 cob(II)alamin--[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] => 2 [corrinoid adenosyltransferase]-cob(I)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":54825,"RHEA_ID":53460,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z)-eicosatrienoate"}
{"X":54826,"RHEA_ID":56795,"compounds":"2 cob(II)alamin--[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] <=> 2 [corrinoid adenosyltransferase]-cob(I)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":54827,"RHEA_ID":53462,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z)-eicosatrienoate => 1-hexadecanoyl-2-(5Z,8Z,11Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol"}
{"X":54828,"RHEA_ID":60217,"DIRECTION":"LR","MASTER_ID":60216,"metacyc":"RXN-20628","compounds":"2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + O2 => CO2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3] + succinate"}
{"X":54829,"RHEA_ID":53464,"compounds":"1-hexadecanoyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (8Z,11Z,14Z)-eicosatrienoate"}
{"X":54830,"RHEA_ID":56799,"compounds":"[corrinoid adenosyltransferase]-cob(I)alamin + ATP <=> adenosylcob(III)alamin + apo-[corrinoid adenosyltransferase] + triphosphate"}
{"X":54831,"RHEA_ID":53466,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (8Z,11Z,14Z)-eicosatrienoate => 1-hexadecanoyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol"}
{"X":54832,"RHEA_ID":60221,"DIRECTION":"LR","MASTER_ID":60220,"metacyc":"RXN-20634","compounds":"2-oxoglutarate + N(6)-methyl-L-lysyl(4)-[histone H3] + O2 => CO2 + formaldehyde + L-lysyl(4)-[histone H3] + succinate"}
{"X":54833,"RHEA_ID":53468,"compounds":"1-hexadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z,14Z,17Z-eicosapentaenoate)"}
{"X":54834,"RHEA_ID":59025,"compounds":"H2O + trihexadecanoylglycerol => dihexadecanoylglycerol + H(+) + hexadecanoate"}
{"X":54835,"RHEA_ID":53470,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z,14Z,17Z-eicosapentaenoate) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phosphocholine + cholesterol"}
{"X":54836,"RHEA_ID":56805,"DIRECTION":"LR","MASTER_ID":56804,"metacyc":"R343-RXN","compounds":"2 cob(II)yrinate a,c diamide--[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] => 2 cob(I)yrinate a,c diamide--[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":54837,"RHEA_ID":53472,"compounds":"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z,12Z)-octadecadienoate"}
{"X":54838,"RHEA_ID":56807,"compounds":"2 cob(II)yrinate a,c diamide--[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] <=> 2 cob(I)yrinate a,c diamide--[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":54839,"RHEA_ID":53474,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z,12Z)-octadecadienoate => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + cholesterol"}
{"X":54840,"RHEA_ID":56809,"DIRECTION":"LR","MASTER_ID":56808,"metacyc":"R344-RXN","compounds":"ATP + cob(I)yrinate a,c diamide--[corrinoid adenosyltransferase] => adenosylcob(III)yrinate a,c-diamide + apo-[corrinoid adenosyltransferase] + triphosphate"}
{"X":54841,"RHEA_ID":59032,"compounds":"(Z)-24-ethylidenelophenol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":54842,"RHEA_ID":54946,"compounds":"(3R)-hydroxy-(5Z)-dodecenoyl-[ACP] + NADP(+) => 3-oxo-(5Z)-dodecenoyl-[ACP] + H(+) + NADPH"}
{"X":54843,"RHEA_ID":53478,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (6Z,9Z,12Z)-octadecatrienoate => 1-hexadecanoyl-2-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol"}
{"X":54844,"RHEA_ID":56812,"DIRECTION":"UN","MASTER_ID":56812,"ec":"1.14.20.15","compounds":"2-oxoglutarate + chloride + H(+) + L-threonyl-[peptidyl-carrier protein] + O2 = 4-chloro-L-threonyl-[peptidyl-carrier protein] + CO2 + H2O + succinate"}
{"X":54845,"RHEA_ID":59036,"compounds":"4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":54846,"RHEA_ID":60234,"compounds":"CO2 + formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + O2"}
{"X":54847,"RHEA_ID":56816,"DIRECTION":"UN","MASTER_ID":56816,"ec":"3.2.2.8","compounds":"a pyrimidine ribonucleoside + H2O = a pyrimidine nucleobase + D-ribose"}
{"X":54848,"RHEA_ID":61505,"DIRECTION":"LR","MASTER_ID":61504,"metacyc":"PELUDP-RXN","compounds":"pelargonidin + UDP-alpha-D-glucose => pelargonidin 3-O-beta-D-glucoside + UDP"}
{"X":54849,"RHEA_ID":53484,"compounds":"androst-4-ene-3,11,17-trione + H(+) + NADPH = 17beta-hydroxyandrost-4-ene-3,11-dione + NADP(+)"}
{"X":54850,"RHEA_ID":57929,"DIRECTION":"LR","MASTER_ID":57928,"metacyc":"RXN-20088","compounds":"ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + H2O + L-glutamine => ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + H(+) + L-glutamate + phosphate"}
{"X":54851,"RHEA_ID":53486,"compounds":"17beta-hydroxyandrost-4-ene-3,11-dione + NADP(+) => androst-4-ene-3,11,17-trione + H(+) + NADPH"}
{"X":54852,"RHEA_ID":56821,"DIRECTION":"LR","MASTER_ID":56820,"metacyc":"RXN-15431","compounds":"AH2 + cyclooctat-9-en-7-ol + O2 => A + cyclooctat-9-ene-5,7-diol + H2O"}
{"X":54853,"RHEA_ID":61511,"compounds":"peonidin + UDP-alpha-D-glucose <=> peonidin 3-O-beta-D-glucoside + UDP"}
{"X":54854,"RHEA_ID":57933,"compounds":"beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + NH4(+) => beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + H(+) + phosphate"}
{"X":54855,"RHEA_ID":56824,"DIRECTION":"UN","MASTER_ID":56824,"ec":"1.14.99.62","compounds":"AH2 + cyclooctat-9-ene-5,7-diol + O2 = A + cyclooctatin + H2O"}
{"X":54856,"RHEA_ID":54592,"DIRECTION":"UN","MASTER_ID":54592,"ec":"2.7.7.50","compounds":"a 5'-end diphospho-(purine-ribonucleoside) in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + diphosphate"}
{"X":54857,"RHEA_ID":54593,"DIRECTION":"LR","MASTER_ID":54592,"metacyc":"MRNA-GUANYLYLTRANSFERASE-RXN","compounds":"a 5'-end diphospho-(purine-ribonucleoside) in mRNA + GTP + H(+) => a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + diphosphate"}
{"X":54858,"RHEA_ID":57936,"DIRECTION":"UN","MASTER_ID":57936,"ec":"1.2.1.102","compounds":"H2O + isopyridoxal + NAD(+) = 5-pyridoxate + 2 H(+) + NADH"}
{"X":54859,"RHEA_ID":56829,"compounds":"2,3,6-trichlorohydroquinone + chloride + glutathione disulfide => 2,3,5,6-tetrachlorohydroquinone + 2 glutathione"}
{"X":54860,"RHEA_ID":53496,"compounds":"1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexanoate"}
{"X":54861,"RHEA_ID":57941,"DIRECTION":"LR","MASTER_ID":57940,"metacyc":"RXN-19755","compounds":"Fe-coproporphyrin III + H(+) + H2O2 => CO2 + 2 H2O + harderoheme III"}
{"X":54862,"RHEA_ID":56832,"DIRECTION":"UN","MASTER_ID":56832,"ec":"1.21.4.5","compounds":"2,6-dichlorohydroquinone + chloride + glutathione disulfide + H(+) = 2,3,6-trichlorohydroquinone + 2 glutathione"}
{"X":54863,"RHEA_ID":54600,"compounds":"2-oxoglutarate + O2 + octanoyl-CoA = 2-hydroxyoctanoyl-CoA + CO2 + succinate"}
{"X":54864,"RHEA_ID":53500,"compounds":"1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-hexanoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)"}
{"X":54865,"RHEA_ID":57945,"DIRECTION":"LR","MASTER_ID":57944,"metacyc":"RXN-19756","compounds":"H(+) + H2O2 + harderoheme III => CO2 + 2 H2O + heme b"}
{"X":54866,"RHEA_ID":54603,"compounds":"2-oxoglutarate + O2 + octanoyl-CoA <=> 2-hydroxyoctanoyl-CoA + CO2 + succinate"}
{"X":54867,"RHEA_ID":61529,"DIRECTION":"LR","MASTER_ID":61528,"metacyc":"RXN-20362","compounds":"a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphingoid base => a diacylglycerol + an N-[omega-(9Z,12Z-octadecadienoyloxy)-O-ultra-long chain fatty acyl]-sphingoid base"}
{"X":54868,"RHEA_ID":53504,"DIRECTION":"UN","MASTER_ID":53504,"ec":"4.1.99.23","compounds":"5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + AH2 + S-adenosyl-L-methionine = 5'-deoxyadenosine + 5-hydroxybenzimidazole + A + formate + 2 H(+) + L-methionine + NH4(+) + phosphate"}
{"X":54869,"RHEA_ID":60259,"compounds":"A + H2O + N(6)-methyl-L-lysyl(4)-[histone H3] <=> AH2 + formaldehyde + L-lysyl(4)-[histone H3]"}
{"X":54870,"RHEA_ID":54607,"compounds":"2-oxoglutarate + decanoyl-CoA + O2 <=> 2-hydroxydecanoyl-CoA + CO2 + succinate"}
{"X":54871,"RHEA_ID":57951,"compounds":"2-hydroxytoluene + H(+) + NADH + O2 <=> 3-methylcatechol + H2O + NAD(+)"}
{"X":54872,"RHEA_ID":60262,"compounds":"3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine => L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine"}
{"X":54873,"RHEA_ID":56843,"compounds":"5-amino-2-hydroxybenzoate + O2 <=> (2Z,4E)-4-amino-6-oxohepta-2,4-dienedioate + H(+)"}
{"X":54874,"RHEA_ID":56844,"DIRECTION":"UN","MASTER_ID":56844,"ec":"2.1.1.351","compounds":"nocamycin E + S-adenosyl-L-methionine = nocamycin I + S-adenosyl-L-homocysteine"}
{"X":54875,"RHEA_ID":57207,"compounds":"glyoxal + L-lysyl-[protein] <=> N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein]"}
{"X":54876,"RHEA_ID":53511,"compounds":"(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione <=> (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate"}
{"X":54877,"RHEA_ID":56847,"compounds":"nocamycin E + S-adenosyl-L-methionine <=> nocamycin I + S-adenosyl-L-homocysteine"}
{"X":54878,"RHEA_ID":60267,"compounds":"L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":54879,"RHEA_ID":57959,"compounds":"dimethyl sulfoxide + H(+) + NADH + O2 <=> dimethyl sulfone + H2O + NAD(+)"}
{"X":54880,"RHEA_ID":60270,"compounds":"H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine"}
{"X":54881,"RHEA_ID":60271,"compounds":"N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":54882,"RHEA_ID":61577,"compounds":"(4R,5R)-4,5-dihydroxycyclohex-2-ene-1-carbonyl-CoA + NADP(+) => (3R,4R)-3,4-dihydroxycyclohexa-1,5-diene-1-carbonyl-CoA + H(+) + NADPH"}
{"X":54883,"RHEA_ID":54620,"compounds":"2-oxoglutarate + eicosanoyl-CoA + O2 = 2-hydroxyeicosanoyl-CoA + CO2 + succinate"}
{"X":54884,"RHEA_ID":54621,"compounds":"2-oxoglutarate + eicosanoyl-CoA + O2 => 2-hydroxyeicosanoyl-CoA + CO2 + succinate"}
{"X":54885,"RHEA_ID":60274,"compounds":"H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine"}
{"X":54886,"RHEA_ID":53889,"compounds":"D-glucose 6-phosphate + TDP-alpha-D-glucose => alpha,alpha-trehalose 6-phosphate + H(+) + TDP"}
{"X":54887,"RHEA_ID":56856,"DIRECTION":"UN","MASTER_ID":56856,"ec":"1.2.99.7","compounds":"A + an aldehyde + H2O = a carboxylate + AH2 + H(+)"}
{"X":54888,"RHEA_ID":53523,"compounds":"1-hexadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z,12Z,15Z)-octadecatrienoate"}
{"X":54889,"RHEA_ID":56858,"compounds":"a carboxylate + AH2 + H(+) => A + an aldehyde + H2O"}
{"X":54890,"RHEA_ID":53525,"compounds":"1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine => a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":54891,"RHEA_ID":56860,"DIRECTION":"UN","MASTER_ID":56860,"ec":"2.3.1.277","compounds":"a medium-chain 3-oxoacyl-[ACP] + dihydroxyacetone phosphate = a 2-oxo-3-(phosphooxy)propyl medium-chain 3-oxoalkanoate + holo-[ACP]"}
{"X":54892,"RHEA_ID":53527,"compounds":"1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine <=> a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":54893,"RHEA_ID":53528,"compounds":"1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-(9Z-octadecenoyl)-1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":54894,"RHEA_ID":54631,"compounds":"2-oxoglutarate + dodecanoyl-CoA + O2 <=> 2-hydroxydodecanoyl-CoA + CO2 + succinate"}
{"X":54895,"RHEA_ID":54632,"compounds":"2-oxoglutarate + O2 + tetradecanoyl-CoA = 2-hydroxytetradecanoyl-CoA + CO2 + succinate"}
{"X":54896,"RHEA_ID":53531,"compounds":"1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine <=> 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-(9Z-octadecenoyl)-1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine"}
{"X":54897,"RHEA_ID":56866,"compounds":"(2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + 6 CO2 + 6 CoA + 4 H2O + NAD(+) + 5 NADP(+) => 12 H(+) + 6 malonyl-CoA + NADH + 5 NADPH"}
{"X":54898,"RHEA_ID":56867,"compounds":"12 H(+) + 6 malonyl-CoA + NADH + 5 NADPH <=> (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + 6 CO2 + 6 CoA + 4 H2O + NAD(+) + 5 NADP(+)"}
{"X":54899,"RHEA_ID":54636,"DIRECTION":"UN","MASTER_ID":54636,"ec":"4.2.3.192","compounds":"(13E)-labda-7,13-dien-15-yl diphosphate = diphosphate + labda-7,13(16),14-triene"}
{"X":54900,"RHEA_ID":53535,"compounds":"(14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate <=> (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O"}
{"X":54901,"RHEA_ID":59093,"DIRECTION":"LR","MASTER_ID":59092,"metacyc":"RXN-20085","compounds":"[(1->3)-alpha-D-glucosyl](n) + sucrose => [(1->3)-alpha-D-glucosyl](n+1) + D-fructose"}
{"X":54902,"RHEA_ID":60291,"compounds":"N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":54903,"RHEA_ID":56872,"DIRECTION":"UN","MASTER_ID":56872,"ec":"3.5.1.85","compounds":"(S)-N-acetyl-1-phenylethylamine + H2O = (S)-1-phenylethylamine + acetate"}
{"X":54904,"RHEA_ID":53539,"compounds":"(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O <=> (13R,14S)-dihydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate"}
{"X":54905,"RHEA_ID":53540,"compounds":"(13R)-S-cysteinylglycinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O = (13R)-S-cysteinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glycine"}
{"X":54906,"RHEA_ID":56875,"compounds":"(S)-N-acetyl-1-phenylethylamine + H2O <=> (S)-1-phenylethylamine + acetate"}
{"X":54907,"RHEA_ID":56876,"compounds":"(R)-N-acetyl-1-phenylethylamine + H2O = (R)-1-phenylethylamine + acetate"}
{"X":54908,"RHEA_ID":53543,"compounds":"(13R)-S-cysteinylglycinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O <=> (13R)-S-cysteinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glycine"}
{"X":54909,"RHEA_ID":53544,"DIRECTION":"UN","MASTER_ID":53544,"ec":"1.17.7.2","compounds":"chlorophyll a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = 7(1)-hydroxychlorophyll a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":54910,"RHEA_ID":61609,"DIRECTION":"LR","MASTER_ID":61608,"metacyc":"RXN-20056","compounds":"[DsbB protein]-dithiol + a quinone => [DsbB protein]-disulfide + a quinol"}
{"X":54911,"RHEA_ID":54648,"DIRECTION":"UN","MASTER_ID":54648,"ec":"4.2.1.173","compounds":"ent-8alpha-hydroxylabd-13-en-15-yl diphosphate = all-trans-geranylgeranyl diphosphate + H2O"}
{"X":54912,"RHEA_ID":61611,"compounds":"[DsbB protein]-dithiol + a quinone <=> [DsbB protein]-disulfide + a quinol"}
{"X":54913,"RHEA_ID":53548,"compounds":"prostaglandin J2 = Delta(12)-prostaglandin J2"}
{"X":54914,"RHEA_ID":56883,"compounds":"a 3beta-hydroxy-Delta(5)-steroid + NADP(+) <=> a 3-oxo-Delta(5)-steroid + H(+) + NADPH"}
{"X":54915,"RHEA_ID":54652,"DIRECTION":"UN","MASTER_ID":54652,"ec":"4.2.1.174","compounds":"peregrinol diphosphate = all-trans-geranylgeranyl diphosphate + H2O"}
{"X":54916,"RHEA_ID":57996,"DIRECTION":"UN","MASTER_ID":57996,"ec":"2.4.1.364","compounds":"(20S)-protopanaxadiol + UDP-alpha-D-glucose = (20S)-ginsenoside Rh2 + H(+) + UDP"}
{"X":54917,"RHEA_ID":61614,"compounds":"7-epi-cylindrospermopsin + CO2 + succinate => 2-oxoglutarate + 7-deoxycylindrospermopsin + O2"}
{"X":54918,"RHEA_ID":60308,"DIRECTION":"UN","MASTER_ID":60308,"ec":"2.1.1.357","compounds":"L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-methionine = 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-homocysteine"}
{"X":54919,"RHEA_ID":54656,"DIRECTION":"UN","MASTER_ID":54656,"ec":"5.4.4.8","compounds":"linalool = geraniol"}
{"X":54920,"RHEA_ID":53555,"compounds":"(9S,10R)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-(9S,10R)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54921,"RHEA_ID":59113,"DIRECTION":"LR","MASTER_ID":59112,"metacyc":"RXN-19819","compounds":"ATP + L-serine => ADP + H(+) + O-phospho-L-serine"}
{"X":54922,"RHEA_ID":60312,"compounds":"L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":54923,"RHEA_ID":56892,"compounds":"H(+) + NADPH + UDP-4-dehydro-beta-L-rhamnose = NADP(+) + UDP-beta-L-rhamnose"}
{"X":54924,"RHEA_ID":54661,"compounds":"an aromatic (S)-hydroxynitrile => an aromatic aldehyde + hydrogen cyanide"}
{"X":54925,"RHEA_ID":58004,"DIRECTION":"UN","MASTER_ID":58004,"ec":"2.4.1.365","compounds":"(20S)-ginsenoside F2 + UDP-alpha-D-glucose = (20S)-ginsenoside Rd + H(+) + UDP"}
{"X":54926,"RHEA_ID":60316,"compounds":"N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":54927,"RHEA_ID":58007,"compounds":"(20S)-ginsenoside F2 + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rd + H(+) + UDP"}
{"X":54928,"RHEA_ID":58008,"DIRECTION":"UN","MASTER_ID":58008,"ec":"2.4.1.367","compounds":"(20S)-ginsenoside F1 + UDP-alpha-D-glucose = (20S)-ginsenoside Rg1 + H(+) + UDP"}
{"X":54929,"RHEA_ID":56897,"compounds":"a carboxylate + ATP + H(+) => an acyl-AMP + diphosphate"}
{"X":54930,"RHEA_ID":56899,"compounds":"a carboxylate + ATP + H(+) <=> an acyl-AMP + diphosphate"}
{"X":54931,"RHEA_ID":56900,"compounds":"globoside GalGb4Cer + UDP-N-acetyl-alpha-D-glucosamine = globoside GlcNAc-(beta1->6)-GalGb4Cer + H(+) + UDP"}
{"X":54932,"RHEA_ID":53567,"compounds":"9,10-epoxy-(12Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-9,10-epoxy-(12Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54933,"RHEA_ID":59125,"DIRECTION":"LR","MASTER_ID":59124,"metacyc":"RXN-19820","compounds":"(S)-2,3-diaminopropanoate + ATP + citrate => 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + AMP + diphosphate"}
{"X":54934,"RHEA_ID":53569,"compounds":"12,13-epoxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-12,13-epoxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54935,"RHEA_ID":56904,"compounds":"an acyl-AMP + CoA = AMP + an acyl-CoA + H(+)"}
{"X":54936,"RHEA_ID":55800,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + N-acyleicosasphinganine + O2 = 2 [Fe(III)-cytochrome b5] + 2 H2O + N-acyleicosasphing-4-enine"}
{"X":54937,"RHEA_ID":58016,"compounds":"8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54938,"RHEA_ID":56907,"compounds":"an acyl-AMP + CoA <=> AMP + an acyl-CoA + H(+)"}
{"X":54939,"RHEA_ID":60329,"DIRECTION":"LR","MASTER_ID":60328,"metacyc":"RXN-20620","compounds":"L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine"}
{"X":54940,"RHEA_ID":53575,"compounds":"8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54941,"RHEA_ID":53576,"compounds":"11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54942,"RHEA_ID":59134,"compounds":"AMP + diphosphate + H(+) + staphyloferrin B => 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + 2-oxoglutarate + ATP"}
{"X":54943,"RHEA_ID":56912,"compounds":"(Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + H2O + NAD(+) = (E)-2-((N-methylformamido) methylene)succinate + 3 H(+) + NADH"}
{"X":54944,"RHEA_ID":53579,"compounds":"11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54945,"RHEA_ID":53580,"compounds":"14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54946,"RHEA_ID":56915,"compounds":"(Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + H2O + NAD(+) <=> (E)-2-((N-methylformamido) methylene)succinate + 3 H(+) + NADH"}
{"X":54947,"RHEA_ID":53582,"compounds":"20-hydroxy-14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":54948,"RHEA_ID":54689,"DIRECTION":"LR","MASTER_ID":54688,"metacyc":"RXN-8898","compounds":"alliin => 2-aminoprop-2-enoate + allylsulfenate"}
{"X":54949,"RHEA_ID":58028,"DIRECTION":"UN","MASTER_ID":58028,"ec":"2.3.1.295","compounds":"5 (S)-methylmalonyl-CoA + a medium-chain fatty acyl-CoA + 32 H(+) + 5 malonyl-CoA + 22 NADPH = a mycoketide-CoA + 10 CO2 + 10 CoA + 11 H2O + 22 NADP(+)"}
{"X":54950,"RHEA_ID":54691,"compounds":"alliin <=> 2-aminoprop-2-enoate + allylsulfenate"}
{"X":54951,"RHEA_ID":56920,"compounds":"a medium chain fatty acid + ATP + H(+) = a medium-chain fatty acyl-AMP + diphosphate"}
{"X":54952,"RHEA_ID":53587,"compounds":"NAD(+) + resolvin D2 <=> 7-oxoresolvin D2 + H(+) + NADH"}
{"X":54953,"RHEA_ID":58032,"compounds":"germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = 8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54954,"RHEA_ID":60343,"compounds":"N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":54955,"RHEA_ID":56924,"DIRECTION":"UN","MASTER_ID":56924,"ec":"2.7.11.9","metacyc":"2.7.11.9-RXN","compounds":"ATP + L-threonyl-[Goodpasture antigen-binding protein] = ADP + H(+) + O-phospho-L-threonyl-[Goodpasture antigen-binding protein]"}
{"X":54956,"RHEA_ID":53591,"compounds":"NAD(+) + resolvin D2 <=> 16-oxoresolvin D2 + H(+) + NADH"}
{"X":54957,"RHEA_ID":60347,"compounds":"L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine"}
{"X":54958,"RHEA_ID":56927,"compounds":"ATP + L-threonyl-[Goodpasture antigen-binding protein] <=> ADP + H(+) + O-phospho-L-threonyl-[Goodpasture antigen-binding protein]"}
{"X":54959,"RHEA_ID":53594,"compounds":"1-tetradecanoyl-sn-glycerol + phosphate => 1-tetradecanoyl-sn-glycerol 3-phosphate + H2O"}
{"X":54960,"RHEA_ID":53595,"compounds":"1-tetradecanoyl-sn-glycerol 3-phosphate + H2O <=> 1-tetradecanoyl-sn-glycerol + phosphate"}
{"X":54961,"RHEA_ID":55825,"DIRECTION":"LR","MASTER_ID":55824,"metacyc":"RXN-18425","compounds":"a 7(1),7(1)-dihydroxybacteriochlorophyllide d => a bacteriochlorophyllide f + H2O"}
{"X":54962,"RHEA_ID":59169,"DIRECTION":"LR","MASTER_ID":59168,"metacyc":"RXN-18542","compounds":"ATP + holo-[(hydroxy)phthioceranic acid synthase] + octadecanoate => AMP + diphosphate + octadecanoyl-[(hydroxy)phthioceranic acid synthase]"}
{"X":54963,"RHEA_ID":56932,"compounds":"androst-5-en-3beta,17beta-diol + NAD(+) = 17beta-hydroxy-androst-5-en-3-one + H(+) + NADH"}
{"X":54964,"RHEA_ID":54705,"DIRECTION":"LR","MASTER_ID":54704,"metacyc":"RXN-12890","compounds":"N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":54965,"RHEA_ID":58044,"DIRECTION":"UN","MASTER_ID":58044,"ec":"2.3.1.279","compounds":"a long-chain fatty acyl-CoA + alpha,alpha-trehalose = 2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + CoA"}
{"X":54966,"RHEA_ID":56934,"compounds":"17beta-hydroxy-androst-5-en-3-one + H(+) + NADH => androst-5-en-3beta,17beta-diol + NAD(+)"}
{"X":54967,"RHEA_ID":56936,"compounds":"17beta-hydroxy-androst-5-en-3-one = testosterone"}
{"X":54968,"RHEA_ID":53603,"compounds":"1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate"}
{"X":54969,"RHEA_ID":53604,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-sn-glycerol + phosphate"}
{"X":54970,"RHEA_ID":56939,"compounds":"17beta-hydroxy-androst-5-en-3-one <=> testosterone"}
{"X":54971,"RHEA_ID":53606,"compounds":"1-hexadecanoyl-sn-glycerol + phosphate => 1-hexadecanoyl-sn-glycero-3-phosphate + H2O"}
{"X":54972,"RHEA_ID":54713,"DIRECTION":"LR","MASTER_ID":54712,"metacyc":"RXN-13225","compounds":"N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine => 3 H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine"}
{"X":54973,"RHEA_ID":53608,"compounds":"4-hydroxyestrone + O2 = (2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + H(+)"}
{"X":54974,"RHEA_ID":56943,"compounds":"5-methylsulfanyl-D-ribulose 1-phosphate <=> 2-(methylthio)acetaldehyde + dihydroxyacetone phosphate"}
{"X":54975,"RHEA_ID":53610,"compounds":"(2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + H(+) => 4-hydroxyestrone + O2"}
{"X":54976,"RHEA_ID":56945,"compounds":"AH2 + D-ribulose 5-phosphate => 1-deoxy-D-xylulose 5-phosphate + A + H2O"}
{"X":54977,"RHEA_ID":60367,"compounds":"H(+)(out) + myo-inositol(out) <=> H(+)(in) + myo-inositol(in)"}
{"X":54978,"RHEA_ID":56947,"compounds":"AH2 + D-ribulose 5-phosphate <=> 1-deoxy-D-xylulose 5-phosphate + A + H2O"}
{"X":54979,"RHEA_ID":56948,"DIRECTION":"UN","MASTER_ID":56948,"ec":"2.7.1.40","compounds":"pyruvate + UTP = H(+) + phosphoenolpyruvate + UDP"}
{"X":54980,"RHEA_ID":55844,"compounds":"calcidiol + UDP-alpha-D-glucuronate = calcidiol 3-O-(beta-D-glucuronide) + H(+) + UDP"}
{"X":54981,"RHEA_ID":58060,"DIRECTION":"UN","MASTER_ID":58060,"metacyc":"RXN-14908","compounds":"2-sulfinoacetaldehyde + H2O = acetaldehyde + H(+) + sulfite"}
{"X":54982,"RHEA_ID":60372,"compounds":"D-fructose(out) = D-fructose(in)"}
{"X":54983,"RHEA_ID":56952,"DIRECTION":"UN","MASTER_ID":56952,"ec":"2.7.1.40","compounds":"CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate"}
{"X":54984,"RHEA_ID":60374,"compounds":"D-fructose(in) => D-fructose(out)"}
{"X":54985,"RHEA_ID":53620,"DIRECTION":"UN","MASTER_ID":53620,"ec":"4.2.3.158","compounds":"all-trans-geranylgeranyl diphosphate = (-)-spiroviolene + diphosphate"}
{"X":54986,"RHEA_ID":60376,"compounds":"D-glucose(out) = D-glucose(in)"}
{"X":54987,"RHEA_ID":60377,"compounds":"D-glucose(out) => D-glucose(in)"}
{"X":54988,"RHEA_ID":56957,"compounds":"ITP + pyruvate => H(+) + IDP + phosphoenolpyruvate"}
{"X":54989,"RHEA_ID":53624,"DIRECTION":"UN","MASTER_ID":53624,"ec":"4.2.3.159","compounds":"all-trans-geranylgeranyl diphosphate = diphosphate + tsukubadiene"}
{"X":54990,"RHEA_ID":60380,"compounds":"L-dehydroascorbate(out) = L-dehydroascorbate(in)"}
{"X":54991,"RHEA_ID":53626,"compounds":"diphosphate + tsukubadiene => all-trans-geranylgeranyl diphosphate"}
{"X":54992,"RHEA_ID":56961,"compounds":"a ribonucleoside 5'-triphosphate + pyruvate => a ribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate"}
{"X":54993,"RHEA_ID":58072,"compounds":"a 4,5-didehydrojasmonate + H(+) + NADPH = a jasmonate + NADP(+)"}
{"X":54994,"RHEA_ID":55859,"compounds":"all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-18-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":54995,"RHEA_ID":58075,"compounds":"a 4,5-didehydrojasmonate + H(+) + NADPH <=> a jasmonate + NADP(+)"}
{"X":54996,"RHEA_ID":58076,"compounds":"1-(11Z-eicosenoyl)-glycerol + H2O = (11Z)-eicosenoate + glycerol + H(+)"}
{"X":54997,"RHEA_ID":56967,"compounds":"a 2'-deoxyribonucleoside 5'-triphosphate + pyruvate <=> a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate"}
{"X":54998,"RHEA_ID":53634,"compounds":"(3S)-(+)-asterisca-2(9),6-diene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":54999,"RHEA_ID":59224,"DIRECTION":"UN","MASTER_ID":59224,"ec":"4.2.3.201","compounds":"all-trans-geranylgeranyl diphosphate = diphosphate + hydropyrene"}
{"X":55000,"RHEA_ID":56970,"compounds":"dCDP + H(+) + phosphoenolpyruvate => dCTP + pyruvate"}
{"X":55001,"RHEA_ID":56971,"compounds":"dCTP + pyruvate <=> dCDP + H(+) + phosphoenolpyruvate"}
{"X":55002,"RHEA_ID":53638,"compounds":"1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine"}
{"X":55003,"RHEA_ID":53639,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphocholine"}
{"X":55004,"RHEA_ID":53640,"DIRECTION":"UN","MASTER_ID":53640,"ec":"4.2.3.162","compounds":"(2E,6E)-farnesyl diphosphate = (-)-alpha-amorphene + diphosphate"}
{"X":55005,"RHEA_ID":54747,"compounds":"9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":55006,"RHEA_ID":53642,"compounds":"(-)-alpha-amorphene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":55007,"RHEA_ID":54749,"DIRECTION":"LR","MASTER_ID":54748,"metacyc":"RXN-18849","compounds":"ATP + CoA + firefly L-luciferin => AMP + diphosphate + L-firefly luciferyl-CoA"}
{"X":55008,"RHEA_ID":54750,"compounds":"AMP + diphosphate + L-firefly luciferyl-CoA => ATP + CoA + firefly L-luciferin"}
{"X":55009,"RHEA_ID":56979,"compounds":"4-methylphenol + H2O + 2 oxidized [azurin] <=> 4-hydroxybenzyl alcohol + 2 H(+) + 2 reduced [azurin]"}
{"X":55010,"RHEA_ID":53646,"compounds":"(+)-corvol ether B + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}
{"X":55011,"RHEA_ID":54753,"DIRECTION":"LR","MASTER_ID":54752,"metacyc":"RXN-8106","compounds":"methanophenazine + reduced coenzyme F420-(gamma-Glu)(n) => dihydromethanophenazine + H(+) + oxidized coenzyme F420-(gamma-Glu)(n)"}
{"X":55012,"RHEA_ID":54754,"compounds":"dihydromethanophenazine + H(+) + oxidized coenzyme F420-(gamma-Glu)(n) => methanophenazine + reduced coenzyme F420-(gamma-Glu)(n)"}
{"X":55013,"RHEA_ID":55882,"compounds":"[aequorin] => apo-[aequorin]--coelenterazine + O2"}
{"X":55014,"RHEA_ID":53650,"compounds":"(+)-corvol ether A + diphosphate => (2E,6E)-farnesyl diphosphate + H2O"}
{"X":55015,"RHEA_ID":58463,"compounds":"an acyl-CoA + sn-glycerol 3-phosphocholine <=> a monoacyl-sn-glycero-3-phosphocholine + CoA"}
{"X":55016,"RHEA_ID":60903,"compounds":"a cytidine in RNA + S-adenosyl-L-methionine <=> an N(3)-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":55017,"RHEA_ID":55123,"compounds":"3-oxo-4-methylhexanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxy-4-methylhexanoyl-[ACP] + NADP(+)"}
{"X":55018,"RHEA_ID":53654,"compounds":"(5S,15S)-dihydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate => (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2"}
{"X":55019,"RHEA_ID":61775,"compounds":"rebaudioside E + UDP-alpha-D-glucose <=> H(+) + rebaudioside D + UDP"}
{"X":55020,"RHEA_ID":59245,"DIRECTION":"LR","MASTER_ID":59244,"ecocyc":"RXN-19911","metacyc":"RXN-19911","compounds":"3''-O-acetyl-ADP-D-ribose + H2O => acetate + ADP-D-ribose + H(+)"}
{"X":55021,"RHEA_ID":60424,"DIRECTION":"UN","MASTER_ID":60424,"ec":"4.2.3.204","compounds":"(2E,6E)-farnesyl diphosphate + H2O = diphosphate + valerianol"}
{"X":55022,"RHEA_ID":53658,"compounds":"(5S,6R)-dihydroxy-(15S)-hydroperoxy-(7E,9E,11Z,13E)-eicosatetraenoate => (5S,6R)-dihydroxy-(7E,9E,11Z,14Z)-eicosatetraenoate + O2"}
{"X":55023,"RHEA_ID":56993,"DIRECTION":"LR","MASTER_ID":56992,"metacyc":"RXN-15459","compounds":"6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) => (+)-costunolide + H2O"}
{"X":55024,"RHEA_ID":55893,"DIRECTION":"LR","MASTER_ID":55892,"metacyc":"RXN-18459","compounds":"a 2-all-trans-polyprenylphenol + H(+) + NADPH + O2 => a 3-(all-trans-polyprenyl)benzene-1,2-diol + H2O + NADP(+)"}
{"X":55025,"RHEA_ID":58105,"compounds":"(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O => (14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate"}
{"X":55026,"RHEA_ID":53662,"compounds":"(5S)-hydroxy-(15S)-hydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate => (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2"}
{"X":55027,"RHEA_ID":60429,"compounds":"(indol-3-yl)acetyl-L-aspartate + H2O => (indol-3-yl)acetate + L-aspartate"}
{"X":55028,"RHEA_ID":61783,"compounds":"keto-L-tagatose <=> keto-L-sorbose"}
{"X":55029,"RHEA_ID":58109,"DIRECTION":"LR","MASTER_ID":58108,"metacyc":"RXN-18952","compounds":"H2O + N(6)-acetyl-L-lysyl-[protein] => acetate + L-lysyl-[protein]"}
{"X":55030,"RHEA_ID":53666,"compounds":"H(+) + 2 H2O + pyridinestrone carboxylate => (2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + NH4(+)"}
{"X":55031,"RHEA_ID":53667,"compounds":"(2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + NH4(+) <=> H(+) + 2 H2O + pyridinestrone carboxylate"}
{"X":55032,"RHEA_ID":53668,"DIRECTION":"UN","MASTER_ID":53668,"ec":"4.2.3.165","compounds":"(2E,6E)-farnesyl diphosphate = (1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate"}
{"X":55033,"RHEA_ID":57003,"compounds":"acetyl-CoA + streptothricin F <=> CoA + H(+) + N(beta)-acetylstreptothricin F"}
{"X":55034,"RHEA_ID":53670,"compounds":"(1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":55035,"RHEA_ID":54777,"DIRECTION":"LR","MASTER_ID":54776,"metacyc":"RXN-19048","compounds":"1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine => [LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+)"}
{"X":55036,"RHEA_ID":53672,"compounds":"2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + AH2 + O2 = 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphoethanolamine + A + H2O"}
{"X":55037,"RHEA_ID":61816,"compounds":"16,17-didehydropregnenolone + UDP-alpha-D-glucose = 16,17-didehydropregnenolone 3-beta-D-glucoside + H(+) + UDP"}
{"X":55038,"RHEA_ID":53674,"compounds":"2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphoethanolamine + A + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + AH2 + O2"}
{"X":55039,"RHEA_ID":60446,"compounds":"an S-substituted L-cysteine + glycine => an S-substitued L-cysteinylglycine + H2O"}
{"X":55040,"RHEA_ID":61820,"compounds":"3beta-hydroxy-5alpha-androstan-17-one + UDP-alpha-D-glucose = epiandrosterone 3-beta-D-glucoside + H(+) + UDP"}
{"X":55041,"RHEA_ID":54783,"compounds":"[LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine <=> [LarE protein]-dehydroalanine + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide"}
{"X":55042,"RHEA_ID":53678,"compounds":"2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2"}
{"X":55043,"RHEA_ID":54785,"compounds":"Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide => Ni(2+) + pyridinium-3,5-bisthiocarboxylate mononucleotide"}
{"X":55044,"RHEA_ID":61824,"compounds":"pregnenolone + UDP-alpha-D-glucose = H(+) + pregnenolone 3-beta-D-glucoside + UDP"}
{"X":55045,"RHEA_ID":57015,"compounds":"a menaquinone + H2O + sulfite <=> a menaquinol + sulfate"}
{"X":55046,"RHEA_ID":53682,"compounds":"2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2"}
{"X":55047,"RHEA_ID":54789,"DIRECTION":"LR","MASTER_ID":54788,"metacyc":"RXN-19046","compounds":"[LarE protein]-L-cysteine + ATP + pyridinium-3,5-dicarboxylate mononucleotide => [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide"}
{"X":55048,"RHEA_ID":58128,"compounds":"A + O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine = AH2 + alstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":55049,"RHEA_ID":57018,"compounds":"3,6-dichlorosalicylate + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 3,6-dichloro-2-methoxybenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":55050,"RHEA_ID":53686,"compounds":"2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2"}
{"X":55051,"RHEA_ID":53687,"compounds":"2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 <=> 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O"}
{"X":55052,"RHEA_ID":58132,"compounds":"A + ajmalicine + O2 + reduced [NADPH--hemoprotein reductase] = AH2 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + serpentine"}
{"X":55053,"RHEA_ID":59278,"compounds":"D-glutamine => L-glutamine"}
{"X":55054,"RHEA_ID":53690,"compounds":"(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine => 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O"}
{"X":55055,"RHEA_ID":53691,"compounds":"2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O <=> (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine"}
{"X":55056,"RHEA_ID":57026,"compounds":"D-xylulose 5-phosphate + dihydroxyacetone phosphate => apulose 4-phosphate + D-glyceraldehyde 3-phosphate"}
{"X":55057,"RHEA_ID":59282,"compounds":"D-asparagine => L-asparagine"}
{"X":55058,"RHEA_ID":54800,"compounds":"[nsP1 protein]-N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidine + a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) = [nsP1 protein]-L-histidine + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA"}
{"X":55059,"RHEA_ID":53695,"compounds":"2-(prostaglandin E2)-sn-glycero-3-phosphocholine + H2O <=> H(+) + prostaglandin E2 + sn-glycerol 3-phosphocholine"}
{"X":55060,"RHEA_ID":55941,"compounds":"all-trans-3,4-didehydroretinol + NAD(+) => all-trans-3,4-didehydroretinal + H(+) + NADH"}
{"X":55061,"RHEA_ID":53697,"compounds":"2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O => (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine"}
{"X":55062,"RHEA_ID":53698,"compounds":"(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine => 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O"}
{"X":55063,"RHEA_ID":53699,"compounds":"2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O <=> (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine"}
{"X":55064,"RHEA_ID":58144,"compounds":"acetate + ATP + cytidine(34) in elongator tRNA(Met) = AMP + diphosphate + N(4)-acetylcytidine(34) in elongator tRNA(Met)"}
{"X":55065,"RHEA_ID":61844,"compounds":"solasodine + UDP-alpha-D-glucose = H(+) + solasodine 3-beta-D-glucoside + UDP"}
{"X":55066,"RHEA_ID":54808,"compounds":"H(+) + L-isoleucine-(+)-7-isojasmonate + NADPH + O2 = H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate + NADP(+)"}
{"X":55067,"RHEA_ID":53703,"compounds":"2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine"}
{"X":55068,"RHEA_ID":59293,"compounds":"beta-D-galactosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O => D-galactose + N-octadecanoylsphing-4-enine"}
{"X":55069,"RHEA_ID":54811,"compounds":"H(+) + L-isoleucine-(+)-7-isojasmonate + NADPH + O2 <=> H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate + NADP(+)"}
{"X":55070,"RHEA_ID":58150,"compounds":"acetate + ethanol + H(+) => ethyl acetate + H2O"}
{"X":55071,"RHEA_ID":53707,"compounds":"2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine + H2O <=> H(+) + prostaglandin E2 + sn-glycero-3-phosphoethanolamine"}
{"X":55072,"RHEA_ID":54814,"compounds":"AMP + diphosphate + H(+) + L-isoleucine-(+)-7-isojasmonate => (+)-7-isojasmonate + ATP + L-isoleucine"}
{"X":55073,"RHEA_ID":54815,"compounds":"(+)-7-isojasmonate + ATP + L-isoleucine <=> AMP + diphosphate + H(+) + L-isoleucine-(+)-7-isojasmonate"}
{"X":55074,"RHEA_ID":60504,"compounds":"1D-myo-inositol 3-phosphate + a CDP-1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)"}
{"X":55075,"RHEA_ID":57045,"compounds":"D-apionate + NAD(+) => 3-oxo-D-isoapionate + H(+) + NADH"}
{"X":55076,"RHEA_ID":57046,"compounds":"3-oxo-D-isoapionate + H(+) + NADH => D-apionate + NAD(+)"}
{"X":55077,"RHEA_ID":54819,"compounds":"L-glutaminyl-[protein] + L-lysyl-[protein] <=> [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+)"}
{"X":55078,"RHEA_ID":57048,"compounds":"AH2 + ATP + cytidine(32) in tRNA + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = 2-thiocytidine(32) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[cysteine desulfurase]"}
{"X":55079,"RHEA_ID":53715,"compounds":"2 Fe(III)-heme b <=> beta-hematin"}
{"X":55080,"RHEA_ID":55961,"compounds":"4-(trimethylamino)butanoate + ATP + CoA => AMP + diphosphate + gamma-butyrobetainyl-CoA"}
{"X":55081,"RHEA_ID":60512,"compounds":"a guanosine in miRNA + S-adenosyl-L-methionine = an N(7)-methylguanosine in miRNA + S-adenosyl-L-homocysteine"}
{"X":55082,"RHEA_ID":58162,"compounds":"diphosphate + dolabradiene => ent-copalyl diphosphate"}
{"X":55083,"RHEA_ID":60514,"compounds":"an N(7)-methylguanosine in miRNA + S-adenosyl-L-homocysteine => a guanosine in miRNA + S-adenosyl-L-methionine"}
{"X":55084,"RHEA_ID":55965,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + GTP => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + GDP + H(+)"}
{"X":55085,"RHEA_ID":54827,"compounds":"H2O + N-{alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-asparaginyl-[protein] <=> alpha-D-glucosyl-(1->3)-D-mannopyranose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)"}
{"X":55086,"RHEA_ID":57055,"compounds":"3-oxo-isoapionate + H(+) <=> CO2 + L-erythrulose"}
{"X":55087,"RHEA_ID":60518,"compounds":"D-tryptophan => L-tryptophan"}
{"X":55088,"RHEA_ID":57058,"compounds":"D-apionolactone + H(+) + NADH => D-apiofuranose + NAD(+)"}
{"X":55089,"RHEA_ID":57059,"compounds":"D-apiofuranose + NAD(+) <=> D-apionolactone + H(+) + NADH"}
{"X":55090,"RHEA_ID":53726,"compounds":"ADP + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate => ATP + N-acetyl-D-glucosamine"}
{"X":55091,"RHEA_ID":57061,"DIRECTION":"LR","MASTER_ID":57060,"ecocyc":"RXN0-7013","metacyc":"RXN0-7013","compounds":"2''-O-acetyl-ADP-D-ribose + H2O => acetate + ADP-D-ribose + H(+)"}
{"X":55092,"RHEA_ID":57062,"compounds":"acetate + ADP-D-ribose + H(+) => 2''-O-acetyl-ADP-D-ribose + H2O"}
{"X":55093,"RHEA_ID":60524,"compounds":"5-hydroxyuridine(34) in tRNA + S-adenosyl-L-methionine = 5-methoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":55094,"RHEA_ID":61873,"compounds":"1-O-methyl-(9Z,12Z)-octadecadienoate + O2 => 1-O-methyl-(9R)-hydroperoxy-(10E,12Z)-octadecadienoate"}
{"X":55095,"RHEA_ID":54838,"compounds":"H2O + NADP(+) + pentyl acetate => H(+) + heptan-2-one + NADPH + O2"}
{"X":55096,"RHEA_ID":57067,"compounds":"D-apionolactone + H2O <=> D-apionate + H(+)"}
{"X":55097,"RHEA_ID":58178,"compounds":"all-trans-lycopaoctaene + 2 diphosphate + NADP(+) => 2 all-trans-geranylgeranyl diphosphate + H(+) + NADPH"}
{"X":55098,"RHEA_ID":57069,"compounds":"3-oxo-isoapionate + ATP => 3-oxo-isoapionate 4-phosphate + ADP + H(+)"}
{"X":55099,"RHEA_ID":53736,"DIRECTION":"UN","MASTER_ID":53736,"ec":"1.14.12.13","compounds":"a 2-halobenzoate + H(+) + NADH + O2 = a halide anion + catechol + CO2 + NAD(+)"}
{"X":55100,"RHEA_ID":59326,"compounds":"D-xylono-1,5-lactone + H2O2 => D-xylose + O2"}
{"X":55101,"RHEA_ID":58181,"DIRECTION":"LR","MASTER_ID":58180,"metacyc":"RXN-19159","compounds":"(1R,2R,3R)-prephytoene diphosphate + H(+) + NADPH => all-trans-lycopaoctaene + diphosphate + NADP(+)"}
{"X":55102,"RHEA_ID":57073,"compounds":"3-oxo-isoapionate 4-phosphate + H(+) => CO2 + L-erythrulose 1-phosphate"}
{"X":55103,"RHEA_ID":55985,"DIRECTION":"LR","MASTER_ID":55984,"metacyc":"RXN-18095","compounds":"(R)-mandelonitrile + UDP-alpha-D-glucose => (R)-prunasin + H(+) + UDP"}
{"X":55104,"RHEA_ID":54847,"compounds":"H(+) + hexan-3-one + NADPH + O2 <=> ethyl butanoate + H2O + NADP(+)"}
{"X":55105,"RHEA_ID":54848,"compounds":"H(+) + hexan-3-one + NADPH + O2 = H2O + NADP(+) + propyl propanoate"}
{"X":55106,"RHEA_ID":57077,"compounds":"3-oxo-isoapionate 4-phosphate + H2O => 3-phosphoglycerate + glycolate + H(+)"}
{"X":55107,"RHEA_ID":54850,"compounds":"H2O + NADP(+) + propyl propanoate => H(+) + hexan-3-one + NADPH + O2"}
{"X":55108,"RHEA_ID":53745,"compounds":"glycyl-tRNA(Ala) + H2O => glycine + H(+) + tRNA(Ala)"}
{"X":55109,"RHEA_ID":53746,"compounds":"glycine + H(+) + tRNA(Ala) => glycyl-tRNA(Ala) + H2O"}
{"X":55110,"RHEA_ID":57081,"DIRECTION":"LR","MASTER_ID":57080,"metacyc":"RXN-14007","compounds":"1-methylsulfanyl-D-xylulose 5-phosphate + glutathione => 1-deoxy-D-xylulose 5-phosphate + S-(methylsulfanyl)glutathione"}
{"X":55111,"RHEA_ID":54854,"compounds":"H2O + NADP(+) + propyl butanoate => H(+) + heptan-4-one + NADPH + O2"}
{"X":55112,"RHEA_ID":54855,"compounds":"H(+) + heptan-4-one + NADPH + O2 <=> H2O + NADP(+) + propyl butanoate"}
{"X":55113,"RHEA_ID":61898,"compounds":"betaenone A => betaenone C"}
{"X":55114,"RHEA_ID":61034,"compounds":"5-hydroxy-3,7,3',4'-tetramethoxyflavone + H(+) + S-adenosyl-L-homocysteine => 3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-methionine"}
{"X":55115,"RHEA_ID":54858,"compounds":"ethyl hexanoate + H2O + NADP(+) => H(+) + NADPH + O2 + octan-3-one"}
{"X":55116,"RHEA_ID":57087,"compounds":"a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O <=> a fatty acid + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+)"}
{"X":55117,"RHEA_ID":53754,"compounds":"a 1,2-diacyl-3-O-[beta-D-glucopyranosyl-(1->6)-beta-D-galactopyranosyl]-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-glucose"}
{"X":55118,"RHEA_ID":57089,"compounds":"an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O => 3-beta-D-galactosyl-sn-glycerol + a fatty acid + H(+)"}
{"X":55119,"RHEA_ID":60583,"compounds":"(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":55120,"RHEA_ID":53757,"compounds":"allodeoxycholoyl-CoA + cholate => allodeoxycholate + choloyl-CoA"}
{"X":55121,"RHEA_ID":54864,"compounds":"H(+) + NADPH + O2 + sulcatone = 4-methylpent-3-en-1-yl acetate + H2O + NADP(+)"}
{"X":55122,"RHEA_ID":53759,"compounds":"allodeoxycholoyl-CoA + cholate <=> allodeoxycholate + choloyl-CoA"}
{"X":55123,"RHEA_ID":57094,"compounds":"A + glutathione + methanethiol => AH2 + S-(methylsulfanyl)glutathione"}
{"X":55124,"RHEA_ID":53761,"compounds":"allocholate + deoxycholoyl-CoA => allocholoyl-CoA + deoxycholate"}
{"X":55125,"RHEA_ID":53762,"compounds":"allocholoyl-CoA + deoxycholate => allocholate + deoxycholoyl-CoA"}
{"X":55126,"RHEA_ID":58207,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine <=> dihydroalstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":55127,"RHEA_ID":57098,"compounds":"1-deoxy-D-xylulose 5-phosphate + A + methanethiol => 1-methylsulfanyl-D-xylulose 5-phosphate + AH2"}
{"X":55128,"RHEA_ID":53765,"compounds":"allocholate + lithocholoyl-CoA => allocholoyl-CoA + lithocholate"}
{"X":55129,"RHEA_ID":60613,"compounds":"1-octanoyl-sn-glycero-3-phosphocholine => 1-octanoyl-sn-glycero-2,3-cyclic phosphate + choline"}
{"X":55130,"RHEA_ID":60614,"compounds":"1-octanoyl-sn-glycero-2,3-cyclic phosphate + choline => 1-octanoyl-sn-glycero-3-phosphocholine"}
{"X":55131,"RHEA_ID":57102,"compounds":"1-methylsulfanyl-D-xylulose 5-phosphate => 5-methylsulfanyl-D-ribulose 1-phosphate"}
{"X":55132,"RHEA_ID":53769,"compounds":"allocholate + allodeoxycholoyl-CoA => allocholoyl-CoA + allodeoxycholate"}
{"X":55133,"RHEA_ID":61918,"compounds":"ADP + fluconazole(out) + H(+) + phosphate => ATP + fluconazole(in) + H2O"}
{"X":55134,"RHEA_ID":60618,"compounds":"ethanolamine + N-dodecanoyl-heptadecasphing-4-enine-1,3-cyclic phosphate => N-dodecanoyl-heptadecasphing-4-enine-1-phosphoethanolamine"}
{"X":55135,"RHEA_ID":57106,"compounds":"4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate + [(1->4)-alpha-D-galacturonosyl](n-2) => [(1->4)-alpha-D-galacturonosyl](n)"}
{"X":55136,"RHEA_ID":53773,"compounds":"chenodeoxycholate + lithocholoyl-CoA => chenodeoxycholoyl-CoA + lithocholate"}
{"X":55137,"RHEA_ID":61922,"compounds":"(2R,4S)-ketoconazole(out) + ADP + H(+) + phosphate => (2R,4S)-ketoconazole(in) + ATP + H2O"}
{"X":55138,"RHEA_ID":60622,"compounds":"choline + N-(hexanoyl)-sphing-4-enine-1,3-cyclic phosphate => N-hexanoyl-sphing-4-enine-1-phosphocholine"}
{"X":55139,"RHEA_ID":57109,"compounds":"1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine"}
{"X":55140,"RHEA_ID":53777,"DIRECTION":"LR","MASTER_ID":53776,"metacyc":"RXN-15364","compounds":"3-mercaptopropanoate + O2 => 3-sulfinopropanoate + H(+)"}
{"X":55141,"RHEA_ID":61926,"compounds":"(2S,4R)-ketoconazole(out) + ADP + H(+) + phosphate => (2S,4R)-ketoconazole(in) + ATP + H2O"}
{"X":55142,"RHEA_ID":53779,"compounds":"3-mercaptopropanoate + O2 <=> 3-sulfinopropanoate + H(+)"}
{"X":55143,"RHEA_ID":54886,"compounds":"H(+) + N(omega)-(2'-phospho-ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide => L-arginyl-[protein] + NADP(+)"}
{"X":55144,"RHEA_ID":58225,"compounds":"L-glutamyl-[protein] + NAD(+) => 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide"}
{"X":55145,"RHEA_ID":53782,"compounds":"beta-muricholoyl-CoA + lithocholate => beta-muricholate + lithocholoyl-CoA"}
{"X":55146,"RHEA_ID":57116,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine"}
{"X":55147,"RHEA_ID":57117,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine"}
{"X":55148,"RHEA_ID":58229,"compounds":"L-asparaginyl-[protein] + NAD(+) => H(+) + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] + nicotinamide"}
{"X":55149,"RHEA_ID":57119,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine"}
{"X":55150,"RHEA_ID":53787,"compounds":"beta-muricholate + deoxycholoyl-CoA <=> beta-muricholoyl-CoA + deoxycholate"}
{"X":55151,"RHEA_ID":57121,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine"}
{"X":55152,"RHEA_ID":53789,"compounds":"allodeoxycholoyl-CoA + beta-muricholate => allodeoxycholate + beta-muricholoyl-CoA"}
{"X":55153,"RHEA_ID":53790,"compounds":"allodeoxycholate + beta-muricholoyl-CoA => allodeoxycholoyl-CoA + beta-muricholate"}
{"X":55154,"RHEA_ID":56036,"compounds":"H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1) = beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3)"}
{"X":55155,"RHEA_ID":57125,"DIRECTION":"LR","MASTER_ID":57124,"metacyc":"RXN-15651","compounds":"2-oxoglutaramate => 2-hydroxy-5-oxoproline"}
{"X":55156,"RHEA_ID":53793,"compounds":"O2 + phenylmethanethiol => benzothialdehyde + H2O2"}
{"X":55157,"RHEA_ID":57126,"compounds":"2-hydroxy-5-oxoproline => 2-oxoglutaramate"}
{"X":55158,"RHEA_ID":54901,"compounds":"(2E)-hexadecenoyl-[ACP] + H(+) + NADH => hexadecanoyl-[ACP] + NAD(+)"}
{"X":55159,"RHEA_ID":54161,"compounds":"2-oxoglutarate + [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + O2 => [ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + CO2 + succinate"}
{"X":55160,"RHEA_ID":53797,"compounds":"deoxycholoyl-CoA + ursodeoxycholate => deoxycholate + ursodeoxycholoyl-CoA"}
{"X":55161,"RHEA_ID":61946,"compounds":"24-methylene cholesteryl beta-D-glucoside + H(+) + UDP => 24-methylenecholesterol + UDP-alpha-D-glucose"}
{"X":55162,"RHEA_ID":58243,"compounds":"H2O + S-(ADP-D-ribosyl)-L-cysteinyl-[protein] <=> ADP-D-ribose + L-cysteinyl-[protein]"}
{"X":55163,"RHEA_ID":57133,"DIRECTION":"LR","MASTER_ID":57132,"metacyc":"RXN-14645","compounds":"L-ascorbate + O2 + tyramine => (2R)-1-(4-hydroxyphenyl)-2-aminoethanol + H2O + L-dehydroascorbate"}
{"X":55164,"RHEA_ID":54907,"compounds":"(2E,9Z)-hexadecadienoyl-[ACP] + H(+) + NADH <=> (9Z)-hexadecenoyl-[ACP] + NAD(+)"}
{"X":55165,"RHEA_ID":57134,"compounds":"(2R)-1-(4-hydroxyphenyl)-2-aminoethanol + H2O + L-dehydroascorbate => L-ascorbate + O2 + tyramine"}
{"X":55166,"RHEA_ID":60654,"compounds":"an N-(acyl)-sphingosyl-1,3-cyclic phosphate + choline => an N-(acyl)-sphingosylphosphocholine"}
{"X":55167,"RHEA_ID":57137,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphoserine"}
{"X":55168,"RHEA_ID":54911,"compounds":"(2E,4E)-hexadienoyl-CoA + H(+) + NADPH <=> (4E)-hexenoyl-CoA + NADP(+)"}
{"X":55169,"RHEA_ID":57138,"compounds":"1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphoserine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine"}
{"X":55170,"RHEA_ID":58251,"compounds":"5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + H2O <=> ADP-D-ribose + H(+) + L-glutamyl-[protein]"}
{"X":55171,"RHEA_ID":58252,"compounds":"H2O + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] = ADP-D-ribose + L-asparaginyl-[protein]"}
{"X":55172,"RHEA_ID":53809,"compounds":"cholestanol + O2 + reduced [NADPH--hemoprotein reductase] => (24S)-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":55173,"RHEA_ID":54916,"compounds":"9-cis-retinol + NADP(+) = 9-cis-retinal + H(+) + NADPH"}
{"X":55174,"RHEA_ID":60662,"compounds":"hydroquinone + NAD(+) => 1,4-benzoquinone + H(+) + NADH"}
{"X":55175,"RHEA_ID":57145,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine => 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)"}
{"X":55176,"RHEA_ID":53813,"compounds":"cholestanol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-26-hydroxycholestanol + H2O + 2 oxidized [adrenodoxin]"}
{"X":55177,"RHEA_ID":59402,"compounds":"D-2-aminohexanoate => L-2-aminohexanoate"}
{"X":55178,"RHEA_ID":61963,"compounds":"a 1-O-hexadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + AH2 + O2 <=> A + a 1-O-(1Z-hexadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 H2O"}
{"X":55179,"RHEA_ID":57149,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)"}
{"X":55180,"RHEA_ID":53817,"compounds":"hydrogen sulfide + O-succinyl-L-serine => L-cysteine + succinate"}
{"X":55181,"RHEA_ID":58262,"compounds":"ADP-D-ribose + L-tyrosyl-[protein] => H2O + O-(ADP-D-ribosyl)-L-tyrosyl-[protein]"}
{"X":55182,"RHEA_ID":61967,"compounds":"a 1-O-octadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + AH2 + O2 <=> A + a 1-O-(1Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 H2O"}
{"X":55183,"RHEA_ID":57153,"DIRECTION":"LR","MASTER_ID":57152,"metacyc":"RXN-20177","compounds":"2-oxoglutarate + L-lysyl-[protein] + O2 => (3S)-3-hydroxy-L-lysyl-[protein] + CO2 + succinate"}
{"X":55184,"RHEA_ID":53821,"compounds":"chenodeoxycholate + NADP(+) => 7-oxolithocholate + H(+) + NADPH"}
{"X":55185,"RHEA_ID":57155,"compounds":"2-oxoglutarate + L-lysyl-[protein] + O2 <=> (3S)-3-hydroxy-L-lysyl-[protein] + CO2 + succinate"}
{"X":55186,"RHEA_ID":58267,"compounds":"a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol <=> an N-acylsphing-4-enine + cholesteryl 3-beta-D-glucoside"}
{"X":55187,"RHEA_ID":57157,"compounds":"2-oxoglutarate + L-lysyl-[protein] + O2 => 4-hydroxy-L-lysyl-[protein] + CO2 + succinate"}
{"X":55188,"RHEA_ID":54931,"compounds":"3-oxo-(9Z)-hexadecenoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] + NADP(+)"}
{"X":55189,"RHEA_ID":58270,"compounds":"[protein]-C-terminal O-(ADP-D-ribosyl)-glycine + nicotinamide => [protein]-C-terminal glycine + NAD(+)"}
{"X":55190,"RHEA_ID":54933,"compounds":"(3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] => (2E,9Z)-hexadecadienoyl-[ACP] + H2O"}
{"X":55191,"RHEA_ID":57161,"compounds":"2-oxoglutarate + L-arginyl-[ribosomal protein eS6] + O2 => (3R)-3-hydroxy-L-arginyl-[ribosomal protein eS6] + CO2 + succinate"}
{"X":55192,"RHEA_ID":53829,"compounds":"2-oxoglutarate + a 5-hydroxymethyl-2'-deoxycytidine in DNA + O2 => a 5-formyl-2'-deoxycytidine in DNA + CO2 + H2O + succinate"}
{"X":55193,"RHEA_ID":57162,"compounds":"(3R)-3-hydroxy-L-arginyl-[ribosomal protein eS6] + CO2 + succinate => 2-oxoglutarate + L-arginyl-[ribosomal protein eS6] + O2"}
{"X":55194,"RHEA_ID":58279,"compounds":"6 ATP <=> cyclic hexaadenylate + 6 diphosphate"}
{"X":55195,"RHEA_ID":58280,"compounds":"4 ATP = cyclic tetraadenylate + 4 diphosphate"}
{"X":55196,"RHEA_ID":53833,"compounds":"2-oxoglutarate + a 5-formyl-2'-deoxycytidine in DNA + O2 => a 5-carboxyl-2'-deoxycytidine in DNA + CO2 + H(+) + succinate"}
{"X":55197,"RHEA_ID":60685,"compounds":"(11R)-dihydroartemisinic aldehyde + H2O + NADP(+) => (11R)-dihydroartemisinate + 2 H(+) + NADPH"}
{"X":55198,"RHEA_ID":58283,"compounds":"4 ATP <=> cyclic tetraadenylate + 4 diphosphate"}
{"X":55199,"RHEA_ID":57169,"DIRECTION":"LR","MASTER_ID":57168,"reactome":"R-HSA-880007.3","compounds":"(R)-2-hydroxyglutarate + FAD + H(+) => 2-oxoglutarate + FADH2"}
{"X":55200,"RHEA_ID":53837,"compounds":"a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-acyl-alpha-D-glucosamine => a UDP-2-N,3-O-bis((3R)-3-hydroxyacyl)-alpha-D-glucosamine + H(+) + holo-[ACP]"}
{"X":55201,"RHEA_ID":60689,"compounds":"(11R)-dihydroartemisinic aldehyde + H2O + NAD(+) => (11R)-dihydroartemisinate + 2 H(+) + NADH"}
{"X":55202,"RHEA_ID":61986,"compounds":"NAD(+) + ubiquinol-10 => H(+) + NADH + ubiquinone-10"}
{"X":55203,"RHEA_ID":55310,"compounds":"1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate"}
{"X":55204,"RHEA_ID":58289,"compounds":"25-substituted-cholesterol + beta-D-glucosyl-N-octanoylsphing-4E-enine => 25-substituted-cholesteryl beta-D-glucoside + N-octanoylsphing-4-enine"}
{"X":55205,"RHEA_ID":57174,"compounds":"2-oxoglutarate + H(+) + NADH => (S)-2-hydroxyglutarate + NAD(+)"}
{"X":55206,"RHEA_ID":58291,"compounds":"25-substituted-cholesterol + beta-D-glucosyl-N-octanoylsphing-4E-enine <=> 25-substituted-cholesteryl beta-D-glucoside + N-octanoylsphing-4-enine"}
{"X":55207,"RHEA_ID":57177,"DIRECTION":"LR","MASTER_ID":57176,"ecocyc":"RXN-17629","metacyc":"RXN-17629","compounds":"L-arginyl-[protein] + methylglyoxal => N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein]"}
{"X":55208,"RHEA_ID":53849,"compounds":"NAD(+) + taurocholate => 7-oxo-taurodeoxycholate + H(+) + NADH"}
{"X":55209,"RHEA_ID":57179,"compounds":"L-arginyl-[protein] + methylglyoxal <=> N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein]"}
{"X":55210,"RHEA_ID":54953,"compounds":"ATP + CoA + nonanoate => AMP + diphosphate + nonanoyl-CoA"}
{"X":55211,"RHEA_ID":57181,"DIRECTION":"LR","MASTER_ID":57180,"ecocyc":"RXN-17631","metacyc":"RXN-17631","compounds":"L-lysyl-[protein] + methylglyoxal => N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein]"}
{"X":55212,"RHEA_ID":54955,"compounds":"ATP + CoA + nonanoate <=> AMP + diphosphate + nonanoyl-CoA"}
{"X":55213,"RHEA_ID":53854,"compounds":"7-oxo-glycodeoxycholate + H(+) + NADH => glycocholate + NAD(+)"}
{"X":55214,"RHEA_ID":57184,"compounds":"L-cysteinyl-[protein] + methylglyoxal = S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein]"}
{"X":55215,"RHEA_ID":57185,"DIRECTION":"LR","MASTER_ID":57184,"ecocyc":"RXN-17633","metacyc":"RXN-17633","compounds":"L-cysteinyl-[protein] + methylglyoxal => S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein]"}
{"X":55216,"RHEA_ID":53857,"compounds":"NADP(+) + ursocholate => 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH"}
{"X":55217,"RHEA_ID":57187,"compounds":"L-cysteinyl-[protein] + methylglyoxal <=> S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein]"}
{"X":55218,"RHEA_ID":53859,"compounds":"NADP(+) + ursocholate <=> 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH"}
{"X":55219,"RHEA_ID":57189,"compounds":"H2O + N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein] => glycolate + H(+) + L-arginyl-[protein]"}
{"X":55220,"RHEA_ID":54963,"compounds":"ATP + CoA + dinor-OPDA <=> AMP + dinor-OPDA-CoA + diphosphate"}
{"X":55221,"RHEA_ID":57190,"compounds":"glycolate + H(+) + L-arginyl-[protein] => H2O + N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein]"}
{"X":55222,"RHEA_ID":58307,"compounds":"25-substituted-cholesterol + beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine <=> 25-substituted-cholesteryl beta-D-glucoside + N-(9Z-octadecenoyl)-sphing-4-enine"}
{"X":55223,"RHEA_ID":57193,"compounds":"H2O + N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein] => glycolate + H(+) + L-lysyl-[protein]"}
{"X":55224,"RHEA_ID":54967,"compounds":"hexadecanoyl-[ACP] + phosphate <=> hexadecanoyl phosphate + holo-[ACP]"}
{"X":55225,"RHEA_ID":57195,"compounds":"H2O + N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein] <=> glycolate + H(+) + L-lysyl-[protein]"}
{"X":55226,"RHEA_ID":57196,"DIRECTION":"UN","MASTER_ID":57196,"ec":"3.5.1.124","compounds":"H2O + S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein] = glycolate + H(+) + L-cysteinyl-[protein]"}
{"X":55227,"RHEA_ID":57197,"compounds":"H2O + S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein] => glycolate + H(+) + L-cysteinyl-[protein]"}
{"X":55228,"RHEA_ID":59461,"compounds":"hexadecan-1-ol + NADP(+) => H(+) + hexadecanal + NADPH"}
{"X":55229,"RHEA_ID":57198,"compounds":"glycolate + H(+) + L-cysteinyl-[protein] => H2O + S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein]"}
{"X":55230,"RHEA_ID":58315,"compounds":"25-substituted-cholesteryl beta-D-glucoside + H2O <=> 25-substituted-cholesterol + D-glucose"}
{"X":55231,"RHEA_ID":57201,"compounds":"glyoxal + L-arginyl-[protein] => N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein]"}
{"X":55232,"RHEA_ID":53873,"compounds":"CTP + D-ribose 5-phosphate + H(+) => CDP-D-ribose + diphosphate"}
{"X":55233,"RHEA_ID":57202,"compounds":"N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein] => glyoxal + L-arginyl-[protein]"}
{"X":55234,"RHEA_ID":54977,"compounds":"(3S)-hydroxytetradecanoyl-CoA + H2O => (3S)-hydroxytetradecanoate + CoA + H(+)"}
{"X":55235,"RHEA_ID":57205,"compounds":"glyoxal + L-lysyl-[protein] => N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein]"}
{"X":55236,"RHEA_ID":53877,"compounds":"a cytidine in tRNA + acetyl-CoA + ATP + H2O => ADP + an N(4)-acetylcytidine in tRNA + CoA + H(+) + phosphate"}
{"X":55237,"RHEA_ID":57583,"compounds":"5-methylsulfanyl-D-ribulose 1-phosphate <=> 1-methylsulfanyl-D-ribulose 5-phosphate"}
{"X":55238,"RHEA_ID":58323,"compounds":"25-substituted-cholesterol + a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine <=> 25-substituted-cholesteryl beta-D-glucoside + an N-acylsphing-4-enine"}
{"X":55239,"RHEA_ID":54982,"compounds":"[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n+1)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenol + 2 GDP + 2 H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-di-trans,octa-cis-undecaprenol + 2 GDP-alpha-D-mannose"}
{"X":55240,"RHEA_ID":56121,"DIRECTION":"LR","MASTER_ID":56120,"metacyc":"RXN-9224","compounds":"2-all-trans-heptaprenylphenol + H(+) + NADPH + O2 => 3-(all-trans-heptaprenyl)benzene-1,2-diol + H2O + NADP(+)"}
{"X":55241,"RHEA_ID":59474,"compounds":"Gp(2'-5')Ap(3') + H(+) => 2',3'-cGAMP + H2O"}
{"X":55242,"RHEA_ID":54985,"compounds":"a ubiquinol => a ubiquinone + 2 e(-) + 2 H(+)"}
{"X":55243,"RHEA_ID":57213,"compounds":"dGTP + methylglyoxal => N(2)-(1-hydroxy-2-oxopropyl)-dGTP"}
{"X":55244,"RHEA_ID":57214,"compounds":"N(2)-(1-hydroxy-2-oxopropyl)-dGTP => dGTP + methylglyoxal"}
{"X":55245,"RHEA_ID":57215,"compounds":"dGTP + methylglyoxal <=> N(2)-(1-hydroxy-2-oxopropyl)-dGTP"}
{"X":55246,"RHEA_ID":60734,"compounds":"2 H(+) + NADPH + perillate => H2O + NADP(+) + perillyl aldehyde"}
{"X":55247,"RHEA_ID":57217,"compounds":"dGTP + glyoxal => N(2)-(1-hydroxy-2-oxoethyl)-dGTP"}
{"X":55248,"RHEA_ID":54250,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine"}
{"X":55249,"RHEA_ID":57219,"compounds":"dGTP + glyoxal <=> N(2)-(1-hydroxy-2-oxoethyl)-dGTP"}
{"X":55250,"RHEA_ID":60738,"compounds":"(2E,6E)-farnesoate + 2 H(+) + NADPH => (2E,6E)-farnesal + H2O + NADP(+)"}
{"X":55251,"RHEA_ID":57221,"compounds":"GTP + methylglyoxal => N(2)-(1-hydroxy-2-oxopropyl)-GTP"}
{"X":55252,"RHEA_ID":57222,"compounds":"N(2)-(1-hydroxy-2-oxopropyl)-GTP => GTP + methylglyoxal"}
{"X":55253,"RHEA_ID":58338,"compounds":"a 4-hydroxynonenal + H(+) + NADPH => a 4-hydroxynonen-1-ol + NADP(+)"}
{"X":55254,"RHEA_ID":57224,"compounds":"glyoxal + GTP = N(2)-(1-hydroxy-2-oxoethyl)-GTP"}
{"X":55255,"RHEA_ID":57225,"compounds":"glyoxal + GTP => N(2)-(1-hydroxy-2-oxoethyl)-GTP"}
{"X":55256,"RHEA_ID":62041,"compounds":"H2O + N-(octanoyl)-sphing-4-enine-1-phosphate => N-octanoylsphing-4-enine + phosphate"}
{"X":55257,"RHEA_ID":55000,"DIRECTION":"UN","MASTER_ID":55000,"ec":"2.4.1.175","compounds":"3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n+1)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP"}
{"X":55258,"RHEA_ID":60746,"compounds":"CoA + pyrethrin I => (1R,3R)-chrysanthemoyl-CoA + (Z,S)-pyrethrolone"}
{"X":55259,"RHEA_ID":58344,"compounds":"beta-D-glucosyl-(1->3)-O-lithocholate + H2O = D-glucose + lithocholate"}
{"X":55260,"RHEA_ID":55003,"compounds":"3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n+1)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP"}
{"X":55261,"RHEA_ID":53902,"compounds":"[myosin light chain]-O-phospho-L-threonine + ADP + H(+) => [myosin light chain]-L-threonine + ATP"}
{"X":55262,"RHEA_ID":60750,"compounds":"CoA + pyrethrin II => (1R,3R)-pyrethroyl-CoA + (Z,S)-pyrethrolone"}
{"X":55263,"RHEA_ID":55006,"compounds":"3-isopropenyl-6-oxoheptanoate + H2O + NADP(+) => 1-hydroxylimonen-2-one + NADPH + O2"}
{"X":55264,"RHEA_ID":58349,"compounds":"2 2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 O2 => 2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate"}
{"X":55265,"RHEA_ID":60753,"compounds":"(1R,3R)-chrysanthemoyl-CoA + (Z,S)-jasmololone => CoA + jasmolin I"}
{"X":55266,"RHEA_ID":60754,"compounds":"CoA + jasmolin I => (1R,3R)-chrysanthemoyl-CoA + (Z,S)-jasmololone"}
{"X":55267,"RHEA_ID":58352,"compounds":"2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + O2 = CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate"}
{"X":55268,"RHEA_ID":53909,"compounds":"(2E)-butenoyl-CoA + L-lysyl-[protein] => CoA + H(+) + N(6)-(2E)-butenoyl-L-lysyl-[protein]"}
{"X":55269,"RHEA_ID":60757,"compounds":"(1R,3R)-chrysanthemoyl-CoA + (Z,S)-cinerolone => cinerin I + CoA"}
{"X":55270,"RHEA_ID":60758,"compounds":"cinerin I + CoA => (1R,3R)-chrysanthemoyl-CoA + (Z,S)-cinerolone"}
{"X":55271,"RHEA_ID":58355,"compounds":"2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + O2 <=> CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate"}
{"X":55272,"RHEA_ID":58357,"compounds":"2-oxoglutarate + N(omega)-methyl-L-arginyl-[protein] + O2 => CO2 + formaldehyde + L-arginyl-[protein] + succinate"}
{"X":55273,"RHEA_ID":60761,"compounds":"(1R,3R)-pyrethroyl-CoA + (Z,S)-jasmololone => CoA + jasmolin II"}
{"X":55274,"RHEA_ID":60762,"compounds":"CoA + jasmolin II => (1R,3R)-pyrethroyl-CoA + (Z,S)-jasmololone"}
{"X":55275,"RHEA_ID":56156,"compounds":"(12R)-hydroxy-(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine = (12R-hydroxy-9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":55276,"RHEA_ID":57246,"compounds":"dGTP + H(+) + lactate => H2O + N(2)-(1-hydroxy-2-oxopropyl)-dGTP"}
{"X":55277,"RHEA_ID":53918,"compounds":"CoA + H(+) + N(6)-acyl-L-lysyl-[protein] => an acyl-CoA + L-lysyl-[protein]"}
{"X":55278,"RHEA_ID":57248,"compounds":"H2O + N(2)-(1-hydroxy-2-oxoethyl)-dGTP = dGTP + glycolate + H(+)"}
{"X":55279,"RHEA_ID":62064,"compounds":"2-deoxy-D-glucose 6-phosphate + NAD(+) = 2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADH"}
{"X":55280,"RHEA_ID":57250,"compounds":"dGTP + glycolate + H(+) => H2O + N(2)-(1-hydroxy-2-oxoethyl)-dGTP"}
{"X":55281,"RHEA_ID":60777,"DIRECTION":"LR","MASTER_ID":60776,"metacyc":"RXN1F-162","compounds":"2-oxoglutarate + gibberellin A12 + O2 => CO2 + gibberellin A15 + succinate"}
{"X":55282,"RHEA_ID":57252,"compounds":"H2O + N(2)-(1-hydroxy-2-oxoethyl)-GTP = glycolate + GTP + H(+)"}
{"X":55283,"RHEA_ID":62068,"compounds":"2-deoxy-D-glucose 6-phosphate + NADP(+) = 2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADPH"}
{"X":55284,"RHEA_ID":58369,"compounds":"(2E,6Z)-nona-2,6-dien-1-ol + NADP(+) => (2E,6Z)-nona-2,6-dienal + H(+) + NADPH"}
{"X":55285,"RHEA_ID":55028,"compounds":"an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + S-adenosyl-L-methionine = an N-methylornithine lipid + H(+) + S-adenosyl-L-homocysteine"}
{"X":55286,"RHEA_ID":57256,"compounds":"H2O + N(2)-(1-hydroxy-2-oxopropyl)-GTP = GTP + H(+) + lactate"}
{"X":55287,"RHEA_ID":60782,"compounds":"CO2 + gibberellin A24 + H2O + succinate => 2-oxoglutarate + gibberellin A15 + O2"}
{"X":55288,"RHEA_ID":58373,"compounds":"(E)-oct-2-en-1-ol + NADP(+) => (2E)-octenal + H(+) + NADPH"}
{"X":55289,"RHEA_ID":53930,"compounds":"a methylated tertiary amine + H(+) + S-adenosyl-L-homocysteine => a tertiary amine + S-adenosyl-L-methionine"}
{"X":55290,"RHEA_ID":60786,"compounds":"CO2 + gibberellin A25 + H(+) + succinate => 2-oxoglutarate + gibberellin A24 + O2"}
{"X":55291,"RHEA_ID":59528,"compounds":"hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein] = CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]"}
{"X":55292,"RHEA_ID":58377,"compounds":"decan-1-ol + NADP(+) => decanal + H(+) + NADPH"}
{"X":55293,"RHEA_ID":53934,"compounds":"19-hydroxy-prostaglandin I2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + prostaglandin I2 + reduced [NADPH--hemoprotein reductase]"}
{"X":55294,"RHEA_ID":57264,"compounds":"H2O + N(2)-(1-hydroxy-2-oxoethyl)-GDP = GDP + glycolate + H(+)"}
{"X":55295,"RHEA_ID":56176,"compounds":"8-demethyl-8-formylriboflavin 5'-phosphate + A + H2O = 8-carboxy-8-demethylriboflavin 5'-phosphate + AH2 + H(+)"}
{"X":55296,"RHEA_ID":58381,"compounds":"NADP(+) + nonan-1-ol => H(+) + NADPH + nonanal"}
{"X":55297,"RHEA_ID":53938,"compounds":"19-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2"}
{"X":55298,"RHEA_ID":53939,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2 <=> 19-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":55299,"RHEA_ID":59536,"compounds":"ATP + butanoyl-CoA + hydrogencarbonate = (2R)-ethylmalonyl-CoA + ADP + H(+) + phosphate"}
{"X":55300,"RHEA_ID":58385,"compounds":"NADP(+) + octan-1-ol => H(+) + NADPH + octanal"}
{"X":55301,"RHEA_ID":53942,"compounds":"18-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2"}
{"X":55302,"RHEA_ID":53943,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2 <=> 18-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":55303,"RHEA_ID":60823,"compounds":"H2O + NADPH <=> adenosine 3',5'-bisphosphate + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide"}
{"X":55304,"RHEA_ID":58389,"DIRECTION":"LR","MASTER_ID":58388,"metacyc":"RXN-14291","compounds":"4-aminobenzoate + all-trans-hexaprenyl diphosphate => 4-amino-3-all-trans-hexaprenylbenzoate + diphosphate"}
{"X":55305,"RHEA_ID":53946,"DIRECTION":"RL","MASTER_ID":53944,"metacyc":"RXN-9564","compounds":"(2E)-2-ethylidene-4-hydroxy-5-methylfuran-3(2H)-one + H(+) + NADPH => 2-ethyl-4-hydroxy-5-methyl-3(2H)-furanone + NADP(+)"}
{"X":55306,"RHEA_ID":53947,"compounds":"2-ethyl-4-hydroxy-5-methyl-3(2H)-furanone + NADP(+) <=> (2E)-2-ethylidene-4-hydroxy-5-methylfuran-3(2H)-one + H(+) + NADPH"}
{"X":55307,"RHEA_ID":56188,"DIRECTION":"UN","MASTER_ID":56188,"ec":"2.4.1.148","compounds":"3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP"}
{"X":55308,"RHEA_ID":58393,"DIRECTION":"LR","MASTER_ID":58392,"metacyc":"RXN-14292","compounds":"4-amino-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":55309,"RHEA_ID":53950,"compounds":"ADP + gamma-L-glutamyl-[BtrI ACP] + phosphate => ATP + holo-[BtrI ACP] + L-glutamate"}
{"X":55310,"RHEA_ID":57280,"compounds":"a guanosine in RNA + glyoxal = an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA"}
{"X":55311,"RHEA_ID":55054,"compounds":"CoA + H(+) + pentanoate => H2O + pentanoyl-CoA"}
{"X":55312,"RHEA_ID":58397,"compounds":"4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + 5 H(+) + O2 + 4 reduced [2Fe-2S]-[ferredoxin] => 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + NH4(+) + 4 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":55313,"RHEA_ID":58398,"compounds":"3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + NH4(+) + 4 oxidized [2Fe-2S]-[ferredoxin] => 4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + 5 H(+) + O2 + 4 reduced [2Fe-2S]-[ferredoxin]"}
{"X":55314,"RHEA_ID":55058,"compounds":"a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => a 12-hydroxyjasmonyl-L-alpha-amino acid + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}
{"X":55315,"RHEA_ID":57286,"compounds":"an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA => a guanosine in RNA + methylglyoxal"}
{"X":55316,"RHEA_ID":53958,"compounds":"4-aminobutanoyl-[BtrI ACP] + CO2 => gamma-L-glutamyl-[BtrI ACP] + H(+)"}
{"X":55317,"RHEA_ID":60838,"compounds":"a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + diphosphate => a 5'-end diphospho-adenosine in mRNA + GTP + H(+)"}
{"X":55318,"RHEA_ID":55062,"compounds":"a 12-oxojasmonyl-L-alpha-amino acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => a 12-hydroxyjasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":55319,"RHEA_ID":57290,"compounds":"a guanosine in RNA + H(+) + lactate => an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA + H2O"}
{"X":55320,"RHEA_ID":53962,"compounds":"4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + FMN + H(+) + H2O => 4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + FMNH2 + O2"}
{"X":55321,"RHEA_ID":58407,"compounds":"hexan-1-ol + NADP(+) <=> H(+) + hexanal + NADPH"}
{"X":55322,"RHEA_ID":56204,"compounds":"CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] = 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + CMP + H(+)"}
{"X":55323,"RHEA_ID":57294,"compounds":"a guanosine in RNA + glycolate + H(+) => an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA + H2O"}
{"X":55324,"RHEA_ID":53966,"compounds":"gamma-L-glutamyl-butirosin B + H(+) + holo-[BtrI ACP] => 4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + ribostamycin"}
{"X":55325,"RHEA_ID":60846,"compounds":"a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + diphosphate => a 5'-end diphospho-guanosine in mRNA + GTP + H(+)"}
{"X":55326,"RHEA_ID":56208,"compounds":"CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] = 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP + H(+)"}
{"X":55327,"RHEA_ID":57298,"compounds":"a 2'-deoxyguanosine in DNA + glycolate + H(+) => an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA + H2O"}
{"X":55328,"RHEA_ID":53970,"compounds":"adenosine 3',5'-bisphosphate + H(+) + holo-[BtrI ACP] => apo-[BtrI ACP] + CoA"}
{"X":55329,"RHEA_ID":55073,"compounds":"2-oxobutanoate + H(+) => CO2 + propanal"}
{"X":55330,"RHEA_ID":58416,"compounds":"(E)-4-hydroxynon-2-en-1-ol + NADP(+) = (E)-4-hydroxynon-2-enal + H(+) + NADPH"}
{"X":55331,"RHEA_ID":57302,"compounds":"a 2'-deoxyguanosine in DNA + H(+) + lactate => an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA + H2O"}
{"X":55332,"RHEA_ID":55076,"compounds":"4-methylsulfanyl-2-oxobutanoate + H(+) = 3-methylsulfanylpropanal + CO2"}
{"X":55333,"RHEA_ID":53975,"compounds":"(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O <=> (8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate"}
{"X":55334,"RHEA_ID":55078,"compounds":"3-methylsulfanylpropanal + CO2 => 4-methylsulfanyl-2-oxobutanoate + H(+)"}
{"X":55335,"RHEA_ID":62125,"compounds":"a 2'-deoxyribonucleoside 5'-phosphate + GTP => a 2'-deoxyribonucleoside 5'-diphosphate + GDP"}
{"X":55336,"RHEA_ID":58422,"compounds":"3-methyl-2-butenal + H(+) + NADPH => NADP(+) + prenol"}
{"X":55337,"RHEA_ID":53979,"compounds":"(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O <=> (14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate"}
{"X":55338,"RHEA_ID":55082,"compounds":"ADP + H(+) + sucrose => ADP-alpha-D-glucose + D-fructose"}
{"X":55339,"RHEA_ID":57310,"compounds":"diphosphate + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine => CTP + H(+) + N(5)-phospho-L-glutamine"}
{"X":55340,"RHEA_ID":53982,"compounds":"(11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate => (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O"}
{"X":55341,"RHEA_ID":53983,"compounds":"(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O <=> (11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate"}
{"X":55342,"RHEA_ID":58428,"compounds":"(E,E)-2,4-hexadien-1-ol + NADP(+) = (E,E)-2,4-hexadienal + H(+) + NADPH"}
{"X":55343,"RHEA_ID":53985,"compounds":"(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O => (11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate"}
{"X":55344,"RHEA_ID":58430,"compounds":"(E,E)-2,4-hexadienal + H(+) + NADPH => (E,E)-2,4-hexadien-1-ol + NADP(+)"}
{"X":55345,"RHEA_ID":55089,"compounds":"24-methylene-24-dihydrolanosterol + S-adenosyl-L-methionine => (24Z)-ethylidenelanosterol + H(+) + S-adenosyl-L-homocysteine"}
{"X":55346,"RHEA_ID":57317,"compounds":"ATP + cytidine 5'-diphosphoramidate => ADP + cytidine 3'-phospho-5'-diphosphoramidate + H(+)"}
{"X":55347,"RHEA_ID":57318,"compounds":"ADP + cytidine 3'-phospho-5'-diphosphoramidate + H(+) => ATP + cytidine 5'-diphosphoramidate"}
{"X":55348,"RHEA_ID":53990,"compounds":"[myosin light chain]-L-threonine + phosphate => [myosin light chain]-O-phospho-L-threonine + H2O"}
{"X":55349,"RHEA_ID":57320,"compounds":"acetyl-CoA + N-terminal L-(Asp/Glu)3-[protein] = CoA + H(+) + N-terminal N-acetyl-L-(Asp/Glu)3-[protein]"}
{"X":55350,"RHEA_ID":57321,"compounds":"acetyl-CoA + N-terminal L-(Asp/Glu)3-[protein] => CoA + H(+) + N-terminal N-acetyl-L-(Asp/Glu)3-[protein]"}
{"X":55351,"RHEA_ID":62141,"compounds":"dTMP + GTP => dTDP + GDP"}
{"X":55352,"RHEA_ID":62140,"DIRECTION":"UN","MASTER_ID":62140,"metacyc":"RXN-17141","compounds":"dTMP + GTP = dTDP + GDP"}
{"X":55353,"RHEA_ID":53995,"compounds":"(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O <=> (14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate"}
{"X":55354,"RHEA_ID":53996,"compounds":"(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = (14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate"}
{"X":55355,"RHEA_ID":60876,"compounds":"a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)"}
{"X":55356,"RHEA_ID":60877,"compounds":"a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O => a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)"}
{"X":55357,"RHEA_ID":57328,"compounds":"acetyl-CoA + N-terminal L-aspartyl-L-aspartyl-L-aspartyl-[protein] = CoA + H(+) + N-terminal N-acetyl-L-aspartyl-L-aspartyl-L-aspartyl-[protein]"}
{"X":55358,"RHEA_ID":57329,"compounds":"acetyl-CoA + N-terminal L-aspartyl-L-aspartyl-L-aspartyl-[protein] => CoA + H(+) + N-terminal N-acetyl-L-aspartyl-L-aspartyl-L-aspartyl-[protein]"}
{"X":55359,"RHEA_ID":54001,"compounds":"(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O => (11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate"}
{"X":55360,"RHEA_ID":54371,"compounds":"acetaldehyde + H(+) + pyruvate <=> acetoin + CO2"}
{"X":55361,"RHEA_ID":57332,"compounds":"H2O + 3 O2 + 3 propionate 3-nitronate = 3 3-oxopropanoate + 3 H(+) + H2O2 + 2 nitrate + nitrite"}
{"X":55362,"RHEA_ID":54004,"compounds":"(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = (11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate"}
{"X":55363,"RHEA_ID":54005,"compounds":"(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O => (11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate"}
{"X":55364,"RHEA_ID":54006,"compounds":"(11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate => (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O"}
{"X":55365,"RHEA_ID":58451,"compounds":"N-terminal N-methyl-L-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N-dimethyl-L-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":55366,"RHEA_ID":57341,"DIRECTION":"LR","MASTER_ID":57340,"metacyc":"RXN-17499","compounds":"3-hydroxy-L-kynurenine + S-adenosyl-L-methionine => 3-hydroxy-4-methyl-L-kynurenine + H(+) + S-adenosyl-L-homocysteine"}
{"X":55367,"RHEA_ID":54009,"compounds":"(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O => (8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate"}
{"X":55368,"RHEA_ID":62162,"compounds":"N-(9Z-octadecenoyl) ethanolamine + phosphate => H2O + N-(9Z-octadecenoyl)-ethanolamine phosphate"}
{"X":55369,"RHEA_ID":60890,"compounds":"(N(7)-methyl 5'-triphospho-guanosine)-guanosine + a 5'-end phospho-ribonucleoside in mRNA + H(+) => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine-phospho-ribonucleoside in mRNA + H2O"}
{"X":55370,"RHEA_ID":60891,"compounds":"a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine-phospho-ribonucleoside in mRNA + H2O <=> (N(7)-methyl 5'-triphospho-guanosine)-guanosine + a 5'-end phospho-ribonucleoside in mRNA + H(+)"}
{"X":55371,"RHEA_ID":54013,"compounds":"(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O => (8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate"}
{"X":55372,"RHEA_ID":60893,"compounds":"a 5'-end NAD(+)-phospho-ribonucleoside in snoRNA + H2O => a 5'-end phospho-ribonucleoside in snoRNA + H(+) + NAD(+)"}
{"X":55373,"RHEA_ID":57348,"compounds":"3-hydroxy-4-methyl-L-kynurenine + H2O = 3-hydroxy-4-methylanthranilate + H(+) + L-alanine"}
{"X":55374,"RHEA_ID":60895,"compounds":"a 5'-end NAD(+)-phospho-ribonucleoside in snoRNA + H2O <=> a 5'-end phospho-ribonucleoside in snoRNA + H(+) + NAD(+)"}
{"X":55375,"RHEA_ID":54017,"compounds":"(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O => (8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate"}
{"X":55376,"RHEA_ID":57351,"compounds":"3-hydroxy-4-methyl-L-kynurenine + H2O <=> 3-hydroxy-4-methylanthranilate + H(+) + L-alanine"}
{"X":55377,"RHEA_ID":61310,"compounds":"germacra-1(10),4,11(13)-trien-12-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-(R)-germacrene A + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":55378,"RHEA_ID":62667,"compounds":"(2'R)-atrovenetin + S-adenosyl-L-methionine <=> deoxyherqueinone + H(+) + S-adenosyl-L-homocysteine"}
{"X":55379,"RHEA_ID":55493,"DIRECTION":"LR","MASTER_ID":55492,"metacyc":"RXN-18942","compounds":"ent-cassa-12,15-dien-2-one + O2 + reduced [NADPH--hemoprotein reductase] => ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":55380,"RHEA_ID":60905,"compounds":"(9Z,12Z,15Z)-octadecatrienoate + O2 => 13-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate"}
{"X":55381,"RHEA_ID":60906,"compounds":"13-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2"}
{"X":55382,"RHEA_ID":57357,"compounds":"2-oxoglutarate + chloride + H(+) + hapalindole U + O2 => CO2 + H2O + hapalindole G + succinate"}
{"X":55383,"RHEA_ID":58469,"compounds":"2 2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 O2 => 2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate"}
{"X":55384,"RHEA_ID":60909,"compounds":"a cytidine in tRNA + S-adenosyl-L-methionine => an N(3)-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":55385,"RHEA_ID":57360,"compounds":"H2O + NADH = (6R)-NADHX"}
{"X":55386,"RHEA_ID":57361,"DIRECTION":"LR","MASTER_ID":57360,"ecocyc":"RXN-12754","metacyc":"RXN-12754","compounds":"H2O + NADH => (6R)-NADHX"}
{"X":55387,"RHEA_ID":57362,"compounds":"(6R)-NADHX => H2O + NADH"}
{"X":55388,"RHEA_ID":59636,"compounds":"D-xylotriose + O2 = D-xylotriono-1,5-lactone + H2O2"}
{"X":55389,"RHEA_ID":60914,"compounds":"H(+) + N(3)-methylcytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-homocysteine => cytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-methionine"}
{"X":55390,"RHEA_ID":60915,"compounds":"cytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-methionine <=> H(+) + N(3)-methylcytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-homocysteine"}
{"X":55391,"RHEA_ID":54033,"compounds":"(6S)-10-formyltetrahydrofolate + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose => (6S)-5,6,7,8-tetrahydrofolate + dTDP-4-formamido-4,6-dideoxy-alpha-D-glucose + H(+)"}
{"X":55392,"RHEA_ID":56272,"compounds":"4 [Fe(III)cytochrome cL] + H2O + methanol = 4 [Fe(II)cytochrome cL] + formate + 5 H(+)"}
{"X":55393,"RHEA_ID":60918,"compounds":"an N(3)-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in mRNA + S-adenosyl-L-methionine"}
{"X":55394,"RHEA_ID":60919,"compounds":"a cytidine in mRNA + S-adenosyl-L-methionine <=> an N(3)-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":55395,"RHEA_ID":55139,"compounds":"ATP + D-alanine + H(+) <=> D-alanyl-5'-AMP + diphosphate"}
{"X":55396,"RHEA_ID":62190,"compounds":"diphosphate + syn-isopimara-7,15-diene => 9alpha-copalyl diphosphate"}
{"X":55397,"RHEA_ID":60922,"compounds":"a cytidine in mRNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + an N(3)-methylcytidine in mRNA + O2"}
{"X":55398,"RHEA_ID":60923,"compounds":"2-oxoglutarate + an N(3)-methylcytidine in mRNA + O2 <=> a cytidine in mRNA + CO2 + formaldehyde + succinate"}
{"X":55399,"RHEA_ID":54041,"DIRECTION":"LR","MASTER_ID":54040,"metacyc":"RXN-18812","compounds":"all-trans-geranylgeranyl diphosphate => (3E,7E)-dolathalia-3,7,11-triene + diphosphate"}
{"X":55400,"RHEA_ID":57375,"compounds":"H2O + NADPH <=> (6S)-NADPHX"}
{"X":55401,"RHEA_ID":60926,"compounds":"CO2 + formaldehyde + L-lysyl-[protein] + succinate => 2-oxoglutarate + N(6)-methyl-L-lysyl-[protein] + O2"}
{"X":55402,"RHEA_ID":55146,"DIRECTION":"RL","MASTER_ID":55144,"metacyc":"RXN-18612","compounds":"[4-(6-methylheptanoyl)-5-oxo-2H-furan-3-yl]methyl phosphate + H(+) + NADPH => [(3S)-4-(6-methylheptanoyl)-5-oxooxolan-3-yl]methyl phosphate + NADP(+)"}
{"X":55403,"RHEA_ID":55147,"compounds":"[(3S)-4-(6-methylheptanoyl)-5-oxooxolan-3-yl]methyl phosphate + NADP(+) <=> [4-(6-methylheptanoyl)-5-oxo-2H-furan-3-yl]methyl phosphate + H(+) + NADPH"}
{"X":55404,"RHEA_ID":57379,"compounds":"(S)-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-1-hydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":55405,"RHEA_ID":57380,"DIRECTION":"UN","MASTER_ID":57380,"ec":"1.14.14.163","compounds":"(S)-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] = (13S,14R)-1,13-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":55406,"RHEA_ID":57381,"DIRECTION":"LR","MASTER_ID":57380,"metacyc":"RXN-19906","compounds":"(S)-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] => (13S,14R)-1,13-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":55407,"RHEA_ID":54049,"DIRECTION":"LR","MASTER_ID":54048,"metacyc":"RXN-18824","compounds":"(2E,6E)-farnesyl diphosphate + H2O => 4-epi-cubebol + diphosphate"}
{"X":55408,"RHEA_ID":57383,"compounds":"(S)-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] <=> (13S,14R)-1,13-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":55409,"RHEA_ID":57384,"DIRECTION":"UN","MASTER_ID":57384,"ec":"2.3.1.285","compounds":"(13S,14R)-1,13-dihydroxy-N-methylcanadine + acetyl-CoA = (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + CoA"}
{"X":55410,"RHEA_ID":57385,"DIRECTION":"LR","MASTER_ID":57384,"metacyc":"RXN-19905","compounds":"(13S,14R)-1,13-dihydroxy-N-methylcanadine + acetyl-CoA => (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + CoA"}
{"X":55411,"RHEA_ID":58497,"compounds":"choline + H(+) + NADH + O2 => glycolaldehyde + H2O + NAD(+) + trimethylamine"}
{"X":55412,"RHEA_ID":55156,"DIRECTION":"UN","MASTER_ID":55156,"ec":"1.8.5.8","compounds":"a quinone + glutathione + H(+) + hydrogen sulfide = a quinol + S-sulfanylglutathione"}
{"X":55413,"RHEA_ID":58499,"compounds":"choline + H(+) + NADH + O2 <=> glycolaldehyde + H2O + NAD(+) + trimethylamine"}
{"X":55414,"RHEA_ID":57389,"compounds":"(13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] => (13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":55415,"RHEA_ID":54057,"DIRECTION":"LR","MASTER_ID":54056,"metacyc":"RXN-18832","compounds":"(2E,6E)-farnesyl diphosphate + H2O => (2E,6E)-hedycaryol + diphosphate"}
{"X":55416,"RHEA_ID":55160,"DIRECTION":"UN","MASTER_ID":55160,"ec":"1.8.7.3","compounds":"coenzyme B + coenzyme M + 2 oxidized [2Fe-2S]-[ferredoxin] = coenzyme M-coenzyme B heterodisulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":55417,"RHEA_ID":57392,"compounds":"(13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine = 3-O-acetyl-4'-O-demethylpapaveroxine + H(+)"}
{"X":55418,"RHEA_ID":60943,"compounds":"(9Z)-hexadecenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (9Z)-16-hydroxyhexadec-9-enoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":55419,"RHEA_ID":58505,"compounds":"(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate => (3Z)-2-oxo-4-carboxy-3-hexenedioate"}
{"X":55420,"RHEA_ID":60945,"DIRECTION":"LR","MASTER_ID":60944,"metacyc":"RXN-8262","compounds":"quercetin + S-adenosyl-L-methionine => H(+) + isorhamnetin + S-adenosyl-L-homocysteine"}
{"X":55421,"RHEA_ID":58507,"compounds":"(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate <=> (3Z)-2-oxo-4-carboxy-3-hexenedioate"}
{"X":55422,"RHEA_ID":58508,"compounds":"(3Z)-2-oxo-4-carboxy-3-hexenedioate + H2O = (2S)-2-hydroxy-4-oxobutane-1,2,4-tricarboxylate"}
{"X":55423,"RHEA_ID":55167,"compounds":"a jasmonyl-L-isoleucinate + H(+) + NADPH + O2 <=> H2O + L-isoleucine-12-hydroxyjasmonate + NADP(+)"}
{"X":55424,"RHEA_ID":60949,"DIRECTION":"LR","MASTER_ID":60948,"metacyc":"RXN-7753","compounds":"(S)-eriodictyol + S-adenosyl-L-methionine => (S)-homoeriodictyol + H(+) + S-adenosyl-L-homocysteine"}
{"X":55425,"RHEA_ID":58511,"compounds":"(3Z)-2-oxo-4-carboxy-3-hexenedioate + H2O <=> (2S)-2-hydroxy-4-oxobutane-1,2,4-tricarboxylate"}
{"X":55426,"RHEA_ID":58512,"compounds":"1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH = 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)"}
{"X":55427,"RHEA_ID":57402,"compounds":"acetate + H(+) + narcotine hemiacetal => 3-O-acetylpapaveroxine + H2O"}
{"X":55428,"RHEA_ID":60953,"DIRECTION":"LR","MASTER_ID":60952,"metacyc":"RXN-3422","compounds":"(E)-5-hydroxyferulate + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + trans-sinapate"}
{"X":55429,"RHEA_ID":57404,"DIRECTION":"UN","MASTER_ID":57404,"ec":"1.1.1.415","compounds":"NAD(+) + narcotine hemiacetal = H(+) + NADH + noscapine"}
{"X":55430,"RHEA_ID":58516,"compounds":"(19S)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] = 15alpha-stemmadenine intermediate I + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":55431,"RHEA_ID":56311,"compounds":"(S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] <=> 1,2-dehydroreticuline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":55432,"RHEA_ID":60957,"compounds":"17-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose => (9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + H(+) + UDP"}
{"X":55433,"RHEA_ID":58518,"compounds":"15alpha-stemmadenine intermediate I + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (19S)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":55434,"RHEA_ID":58520,"compounds":"(19S)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] = akuammicine + formate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":55435,"RHEA_ID":57410,"DIRECTION":"RL","MASTER_ID":57408,"ecocyc":"RXN-7632","metacyc":"RXN-7632","compounds":"3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADH => (2R)-3-(3,4-dihydroxyphenyl)lactate + NAD(+)"}
{"X":55436,"RHEA_ID":55180,"compounds":"2-oxoglutarate + 3-methylnonanoyl-CoA + O2 = 2-hydroxy-3-methylnonanoyl-CoA + CO2 + succinate"}
{"X":55437,"RHEA_ID":57412,"DIRECTION":"UN","MASTER_ID":57412,"ec":"1.2.1.101","compounds":"AMP + diphosphate + L-tyrosinal + NADP(+) = ATP + H(+) + L-tyrosine + NADPH"}
{"X":55438,"RHEA_ID":60963,"compounds":"18-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose <=> (9Z)-18-hydroxyoctadec-9-enoate 18-O-beta-D-glucoside + H(+) + UDP"}
{"X":55439,"RHEA_ID":54081,"DIRECTION":"LR","MASTER_ID":54080,"ecocyc":"RXN0-7167","metacyc":"RXN0-7167","compounds":"5-carboxymethoxyuridine(34) in tRNA + S-adenosyl-L-methionine => 5-methoxycarbonylmethoxyuridine(34) in tRNA + S-adenosyl-L-homocysteine"}
{"X":55440,"RHEA_ID":55184,"compounds":"2-oxoglutarate + 3-methylundecanoyl-CoA + O2 = 2-hydroxy-3-methylundecanoyl-CoA + CO2 + succinate"}
{"X":55441,"RHEA_ID":57416,"compounds":"H2O + L-asparaginyl-[protein] = L-aspartyl-[protein] + NH4(+)"}
{"X":55442,"RHEA_ID":57417,"compounds":"H2O + L-asparaginyl-[protein] => L-aspartyl-[protein] + NH4(+)"}
{"X":55443,"RHEA_ID":57418,"compounds":"L-aspartyl-[protein] + NH4(+) => H2O + L-asparaginyl-[protein]"}
{"X":55444,"RHEA_ID":54086,"compounds":"archaeosine(15) in tRNA + L-glutamate => 7-cyano-7-carbaguanosine(15) in tRNA + H2O + L-glutamine"}
{"X":55445,"RHEA_ID":55189,"compounds":"5-methyluridine(54) in tRNA + ATP + hydrogen sulfide => 5-methyl-2-thiouridine(54) in tRNA + AMP + diphosphate"}
{"X":55446,"RHEA_ID":58532,"compounds":"15alpha-stemmadenine intermediate I + H2O = akuammicine + formate + H(+)"}
{"X":55447,"RHEA_ID":57422,"compounds":"H(+) + NAD(+) + 2 reduced [cytochrome P450] => NADH + 2 oxidized [cytochrome P450]"}
{"X":55448,"RHEA_ID":60977,"compounds":"(E)-4-hydroxynon-2-en-1-ol + NAD(+) => (E)-4-hydroxynon-2-enal + H(+) + NADH"}
{"X":55449,"RHEA_ID":58535,"compounds":"15alpha-stemmadenine intermediate I + H2O <=> akuammicine + formate + H(+)"}
{"X":55450,"RHEA_ID":60979,"compounds":"(E)-4-hydroxynon-2-en-1-ol + NAD(+) <=> (E)-4-hydroxynon-2-enal + H(+) + NADH"}
{"X":55451,"RHEA_ID":57426,"compounds":"catechol + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] => guaiacol + O2 + reduced [NADH--hemoprotein reductase]"}
{"X":55452,"RHEA_ID":54094,"compounds":"2,4,5-trihydroxyphenylacetate + H2O + NADP(+) => 3,4-dihydroxyphenylacetate + H(+) + NADPH + O2"}
{"X":55453,"RHEA_ID":56333,"compounds":"5'-triphosphoadenylyl-(2'->5')-adenosine + H2O => AMP + ATP + H(+)"}
{"X":55454,"RHEA_ID":60983,"compounds":"12-hydroxydodecanoate + NAD(+) <=> 12-oxododecanoate + H(+) + NADH"}
{"X":55455,"RHEA_ID":54097,"DIRECTION":"LR","MASTER_ID":54096,"metacyc":"RXN-12889","compounds":"N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":55456,"RHEA_ID":54097,"DIRECTION":"LR","MASTER_ID":54096,"metacyc":"RXN-15120","compounds":"N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":55457,"RHEA_ID":56337,"DIRECTION":"LR","MASTER_ID":56336,"metacyc":"RXN-18939","compounds":"ent-isokaurene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => ent-isokaurene-2beta,3beta-diol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":55458,"RHEA_ID":60987,"compounds":"16-hydroxyhexadecanoate + NAD(+) <=> 16-oxohexadecanoate + H(+) + NADH"}
{"X":55459,"RHEA_ID":54100,"DIRECTION":"UN","MASTER_ID":54100,"ec":"2.1.1.299","compounds":"N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":55460,"RHEA_ID":54101,"DIRECTION":"LR","MASTER_ID":54100,"metacyc":"RXN-13227","compounds":"N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":55461,"RHEA_ID":54101,"DIRECTION":"LR","MASTER_ID":54100,"metacyc":"RXN-15120","compounds":"N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":55462,"RHEA_ID":55206,"compounds":"5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H(+) + L-methionine + NH4(+) => 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine"}
{"X":55463,"RHEA_ID":55207,"compounds":"5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H(+) + L-methionine + NH4(+)"}
{"X":55464,"RHEA_ID":60997,"compounds":"H2O + L-leucine + O2 => 4-methyl-2-oxopentanoate + H2O2 + NH4(+)"}
{"X":55465,"RHEA_ID":55209,"compounds":"4-hydroxysphinganine 1-phosphate => (2R)-hydroxyhexadecanal + phosphoethanolamine"}
{"X":55466,"RHEA_ID":58552,"compounds":"15alpha-stemmadenine intermediate II + H2O = (16R)-deshydroxymethyl-stemmadenine + formate"}
{"X":55467,"RHEA_ID":55211,"compounds":"4-hydroxysphinganine 1-phosphate <=> (2R)-hydroxyhexadecanal + phosphoethanolamine"}
{"X":55468,"RHEA_ID":54107,"compounds":"N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":55469,"RHEA_ID":61022,"compounds":"5'-deoxyadenosine + carboxymethyluridine(34) in tRNA + CoA + 2 H(+) + L-methionine => acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA"}
{"X":55470,"RHEA_ID":57445,"DIRECTION":"LR","MASTER_ID":57444,"metacyc":"3.4.17.17-RXN","compounds":"C-terminal L-tyrosyl-L-glutamyl-L-glutamyl-[alpha-tubulin] + H2O => C-terminal detyrosinated L-glutamyl-L-glutamyl-[alpha-tubulin] + L-tyrosine"}
{"X":55471,"RHEA_ID":55215,"compounds":"(2R)-hydroxyhexadecanoyl-CoA <=> formyl-CoA + pentadecanal"}
{"X":55472,"RHEA_ID":55216,"DIRECTION":"UN","MASTER_ID":55216,"ec":"4.2.3.195","compounds":"all-trans-geranylgeranyl diphosphate = diphosphate + rhizathalene A"}
{"X":55473,"RHEA_ID":56353,"DIRECTION":"LR","MASTER_ID":56352,"metacyc":"RXN-19061","compounds":"4-hydroxybenzoate + bromide + 2 H(+) + NADPH + O2 => 3-bromo-4-hydroxybenzoate + 2 H2O + NADP(+)"}
{"X":55474,"RHEA_ID":57449,"compounds":"ATP + D-tyrosine + tRNA(Tyr) => AMP + D-tyrosyl-tRNA(Tyr) + diphosphate + H(+)"}
{"X":55475,"RHEA_ID":54114,"compounds":"diphosphate + selina-4(15),7(11)-diene => (2E,6E)-farnesyl diphosphate"}
{"X":55476,"RHEA_ID":61033,"DIRECTION":"LR","MASTER_ID":61032,"metacyc":"RXN-13838","compounds":"3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-methionine => 5-hydroxy-3,7,3',4'-tetramethoxyflavone + H(+) + S-adenosyl-L-homocysteine"}
{"X":55477,"RHEA_ID":58943,"compounds":"(1R,2R,3R)-prephytoene diphosphate + H(+) + NADH <=> all-trans-lycopaoctaene + diphosphate + NAD(+)"}
{"X":55478,"RHEA_ID":62272,"compounds":"4 (R)-2-hydroxy-3-methylbutyrate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine = 8 AMP + bassianolide + 8 diphosphate + 8 H(+) + 4 S-adenosyl-L-homocysteine"}
{"X":55479,"RHEA_ID":61035,"compounds":"3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-methionine <=> 5-hydroxy-3,7,3',4'-tetramethoxyflavone + H(+) + S-adenosyl-L-homocysteine"}
{"X":55480,"RHEA_ID":55224,"compounds":"4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 4beta-hydroxymethyl-4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":55481,"RHEA_ID":56361,"DIRECTION":"LR","MASTER_ID":56360,"metacyc":"RXN-16478","compounds":"13-deoxycarminomycin + H(+) + NADPH + O2 => 13-dihydrocarminomycin + H2O + NADP(+)"}
{"X":55482,"RHEA_ID":62276,"compounds":"3 (R)-2-hydroxy-3-methylbutyrate + 6 ATP + 3 L-phenylalanine + 3 S-adenosyl-L-methionine = 6 AMP + beauvericin + 6 diphosphate + 6 H(+) + 3 S-adenosyl-L-homocysteine"}
{"X":55483,"RHEA_ID":54122,"compounds":"coelenterazine h dioxetanone => coelenterazine h + O2"}
{"X":55484,"RHEA_ID":61045,"compounds":"(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] => (-)-(R)-19-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":55485,"RHEA_ID":58571,"compounds":"15alpha-stemmadenine + acetyl-CoA <=> CoA + O-acetyl-15alpha-stemmadenine"}
{"X":55486,"RHEA_ID":58572,"compounds":"O-acetyl-15alpha-stemmadenine + O2 = H2O2 + precondylocarpine acetate"}
{"X":55487,"RHEA_ID":54126,"compounds":"CO2 + excited coelenteramide h monoanion + H(+) => coelenterazine h dioxetanone"}
{"X":55488,"RHEA_ID":55232,"compounds":"3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 [Fe(II)-cytochrome b5] + H(+) + O2 = 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate + 2 [Fe(III)-cytochrome b561] + H2O"}
{"X":55489,"RHEA_ID":56369,"DIRECTION":"LR","MASTER_ID":56368,"metacyc":"RXN-19114","compounds":"3,4-dihydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 => 3,5-dibromobenzene-1,2-diol + CO2 + 4 H2O + 2 NADP(+)"}
{"X":55490,"RHEA_ID":57465,"compounds":"(E)-caffeate + UDP-alpha-D-glucose => 1-O-[(E)-caffeoyl]-beta-D-glucose + UDP"}
{"X":55491,"RHEA_ID":57845,"DIRECTION":"LR","MASTER_ID":57844,"metacyc":"RXN-20026","compounds":"fraxetin + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sideretin (reduced form)"}
{"X":55492,"RHEA_ID":54131,"compounds":"3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP"}
{"X":55493,"RHEA_ID":55237,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H2O => (9Z)-octadecenoate + 1-octadecanoyl-2-hydroxy-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H(+)"}
{"X":55494,"RHEA_ID":61055,"compounds":"(-)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase] <=> (-)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":55495,"RHEA_ID":57470,"compounds":"1-O-[(E)-feruloyl]-beta-D-glucose + UDP => trans-ferulate + UDP-alpha-D-glucose"}
{"X":55496,"RHEA_ID":58581,"compounds":"dihydroprecondylocarpine acetate => acetate + catharanthine + H(+)"}
{"X":55497,"RHEA_ID":59745,"compounds":"(9Z)-octadecenoyl-CoA + L-cysteinyl-[protein] => CoA + S-(9Z-octadecenoyl)-L-cysteinyl-[protein]"}
{"X":55498,"RHEA_ID":62294,"compounds":"1-hydroxy-3-{[2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl]methyl}-6H,7H,8H-5lambda5-pyrrolo[1,2-a]pyrazine + AH2 => (8aS)-3-{[2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl]methyl}-1H,2H,6H,7H,8H,8aH-pyrrolo[1,2-a]pyrazin-1-one + A + H(+)"}
{"X":55499,"RHEA_ID":54138,"compounds":"5-methylcytidine(48) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine => cytidine(48) in tRNA precursor + S-adenosyl-L-methionine"}
{"X":55500,"RHEA_ID":54139,"compounds":"cytidine(48) in tRNA precursor + S-adenosyl-L-methionine <=> 5-methylcytidine(48) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine"}
{"X":55501,"RHEA_ID":58586,"compounds":"(-)-tabersonine + acetate + H(+) => dihydroprecondylocarpine acetate"}
{"X":55502,"RHEA_ID":61071,"compounds":"acetyl-CoA + horhammericine <=> 19-O-acetylhorhammericine + CoA"}
{"X":55503,"RHEA_ID":54142,"compounds":"5-methylcytidine(49) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine => cytidine(49) in tRNA precursor + S-adenosyl-L-methionine"}
{"X":55504,"RHEA_ID":54143,"compounds":"cytidine(49) in tRNA precursor + S-adenosyl-L-methionine <=> 5-methylcytidine(49) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine"}
{"X":55505,"RHEA_ID":54144,"compounds":"2 2-oxoglutarate + 5-methylcytidine(34) in mitochondrial tRNA(Met) + 2 O2 = 5-formylcytidine(34) in mitochondrial tRNA(Met) + 2 CO2 + H2O + 2 succinate"}
{"X":55506,"RHEA_ID":62304,"compounds":"1-hydroxy-3-{[2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine = (+)-premalbrancheamide"}
{"X":55507,"RHEA_ID":57482,"compounds":"2,3-dihydroxydodecanoate + H2O => 2-hydroxydodecanoate + H2O2"}
{"X":55508,"RHEA_ID":54147,"compounds":"2 2-oxoglutarate + 5-methylcytidine(34) in mitochondrial tRNA(Met) + 2 O2 <=> 5-formylcytidine(34) in mitochondrial tRNA(Met) + 2 CO2 + H2O + 2 succinate"}
{"X":55509,"RHEA_ID":55253,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine => 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":55510,"RHEA_ID":55254,"compounds":"2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine"}
{"X":55511,"RHEA_ID":57494,"compounds":"2-methylcitrate + CoA + H(+) => H2O + oxaloacetate + propanoyl-CoA"}
{"X":55512,"RHEA_ID":54151,"DIRECTION":"BI","MASTER_ID":54148,"metacyc":"RXN-12723","compounds":"1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene <=> 1-hydroxy-all-trans-1,2-dihydro-neurosporene + H2O"}
{"X":55513,"RHEA_ID":54152,"compounds":"a uridine in rRNA + S-adenosyl-L-methionine = a 2'-O-methyluridine in rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":55514,"RHEA_ID":61083,"compounds":"(+)-minovincinine + acetyl-CoA <=> (+)-echitovenine + CoA"}
{"X":55515,"RHEA_ID":57498,"compounds":"2-methyl-cis-aconitate + H2O => 2-methylcitrate"}
{"X":55516,"RHEA_ID":54155,"compounds":"a uridine in rRNA + S-adenosyl-L-methionine <=> a 2'-O-methyluridine in rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":55517,"RHEA_ID":55261,"compounds":"2 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":55518,"RHEA_ID":59782,"compounds":"(2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine => L-histidine + S-adenosyl-L-methionine"}
{"X":55519,"RHEA_ID":57502,"compounds":"2-methyl-cis-aconitate + H2O => 3-hydroxybutane-1,2,3-tricarboxylate"}
{"X":55520,"RHEA_ID":54159,"compounds":"2-oxoglutarate + [ribosomal protein uS12]-L-proline + O2 <=> [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + CO2 + succinate"}
{"X":55521,"RHEA_ID":54160,"compounds":"2-oxoglutarate + [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + O2 = [ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + CO2 + succinate"}
{"X":55522,"RHEA_ID":61455,"compounds":"H(+) + NADPH + O2 + oxytetracycline <=> 11a-hydroxy-oxytetracycline + H2O + NADP(+)"}
{"X":55523,"RHEA_ID":57506,"compounds":"pyruvate + succinate => 3-hydroxybutane-1,2,3-tricarboxylate"}
{"X":55524,"RHEA_ID":57507,"compounds":"3-hydroxybutane-1,2,3-tricarboxylate <=> pyruvate + succinate"}
{"X":55525,"RHEA_ID":54164,"compounds":"a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + S-adenosyl-L-methionine = a 5'-(N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":55526,"RHEA_ID":54165,"compounds":"a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + S-adenosyl-L-methionine => a 5'-(N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":55527,"RHEA_ID":57510,"DIRECTION":"RL","MASTER_ID":57508,"metacyc":"RXN-19816","compounds":"(2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate => H2O + NADP(+) + staphylopine"}
{"X":55528,"RHEA_ID":54167,"compounds":"a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + S-adenosyl-L-methionine <=> a 5'-(N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":55529,"RHEA_ID":54168,"compounds":"a 5'-(N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + S-adenosyl-L-methionine = a 5'-(N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":55530,"RHEA_ID":57513,"compounds":"chlorobenzene + H(+) + NADH + O2 => (1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+)"}
{"X":55531,"RHEA_ID":57514,"compounds":"(1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+) => chlorobenzene + H(+) + NADH + O2"}
{"X":55532,"RHEA_ID":54171,"compounds":"a 5'-(N(2),N(7)-dimethyl 5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + S-adenosyl-L-methionine <=> a 5'-(N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":55533,"RHEA_ID":58623,"compounds":"N-decanoyl-(2S)-hydroxyglycine <=> decanamide + glyoxylate"}
{"X":55534,"RHEA_ID":57517,"DIRECTION":"LR","MASTER_ID":57516,"metacyc":"RXN-19636","compounds":"dolabradiene + O2 + reduced [NADPH--hemoprotein reductase] => 15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":55535,"RHEA_ID":54174,"compounds":"L-lysyl-[protein] + nicotinamide + O-acyl-ADP-D-ribose => H2O + N(6)-acyl-L-lysyl-[protein] + NAD(+)"}
{"X":55536,"RHEA_ID":54175,"compounds":"H2O + N(6)-acyl-L-lysyl-[protein] + NAD(+) <=> L-lysyl-[protein] + nicotinamide + O-acyl-ADP-D-ribose"}
{"X":55537,"RHEA_ID":57520,"DIRECTION":"UN","MASTER_ID":57520,"ec":"1.14.14.159","compounds":"15,16-epoxydolabrene + O2 + reduced [NADPH--hemoprotein reductase] = 3beta-hydroxy-15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":55538,"RHEA_ID":61107,"compounds":"(S)-naringenin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (2S)-dihydrotricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":55539,"RHEA_ID":57522,"compounds":"3beta-hydroxy-15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 15,16-epoxydolabrene + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":55540,"RHEA_ID":58630,"compounds":"FADH2 + H2O + NADP(+) + rifamycin SV hemiaminal => FADH2-C4alpha-hydroperoxide + H(+) + NADPH + rifamycin SV"}
{"X":55541,"RHEA_ID":58631,"compounds":"FADH2-C4alpha-hydroperoxide + H(+) + NADPH + rifamycin SV <=> FADH2 + H2O + NADP(+) + rifamycin SV hemiaminal"}
{"X":55542,"RHEA_ID":62340,"compounds":"(+)-premalbrancheamide + bromide + FAD + 2 H(+) = (+)-malbrancheamide C + FADH2"}
{"X":55543,"RHEA_ID":54182,"DIRECTION":"RL","MASTER_ID":54180,"metacyc":"RXN-11706","compounds":"a long-chain fatty acyl-[ACP] + H(+) + NADH => a long-chain fatty aldehyde + holo-[ACP] + NAD(+)"}
{"X":55544,"RHEA_ID":58635,"compounds":"N-tetradecanoyl-(2S)-hydroxyglycine <=> glyoxylate + tetradecamide"}
{"X":55545,"RHEA_ID":57529,"compounds":"5'-end ribonucleotide-RNA + a ribonucleoside 5'-triphosphate + ATP + H2O => 5'-phospho-ribonucleosidyl-ribonucleotide-RNA + AMP + 2 diphosphate + H(+)"}
{"X":55546,"RHEA_ID":54186,"compounds":"a carboxylate + an aromatic L-alpha-amino acid => an N-acyl-aromatic L-alpha-amino acid + H2O"}
{"X":55547,"RHEA_ID":58639,"compounds":"N-(9Z-octadecenoyl)-(2S)-hydroxyglycine <=> (9Z)-octadecenamide + glyoxylate"}
{"X":55548,"RHEA_ID":56430,"compounds":"(9Z,12Z)-octadecadienoate + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H(+) => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O"}
{"X":55549,"RHEA_ID":55295,"compounds":"pseudouridine(54) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylpseudouridine(54) in tRNA + S-adenosyl-L-homocysteine"}
{"X":55550,"RHEA_ID":54191,"compounds":"H2O + N-acetyl-L-phenylalanine <=> acetate + L-phenylalanine"}
{"X":55551,"RHEA_ID":57536,"compounds":"a ribonucleoside 5'-triphosphate + adenosine-5'-diphospho-5'-ribonucleotide-RNA = 5'-NTP-ribonucleotide-RNA + AMP + H(+)"}
{"X":55552,"RHEA_ID":57537,"compounds":"a ribonucleoside 5'-triphosphate + adenosine-5'-diphospho-5'-ribonucleotide-RNA => 5'-NTP-ribonucleotide-RNA + AMP + H(+)"}
{"X":55553,"RHEA_ID":54194,"compounds":"3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine => L-lysyl-[protein] + 3 S-adenosyl-L-methionine"}
{"X":55554,"RHEA_ID":57539,"compounds":"a ribonucleoside 5'-triphosphate + adenosine-5'-diphospho-5'-ribonucleotide-RNA <=> 5'-NTP-ribonucleotide-RNA + AMP + H(+)"}
{"X":55555,"RHEA_ID":54196,"compounds":"N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":55556,"RHEA_ID":55302,"compounds":"1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate"}
{"X":55557,"RHEA_ID":55303,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate <=> 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":55558,"RHEA_ID":57543,"compounds":"5'-NTP-ribonucleotide-RNA + H2O <=> 5'-phospho-ribonucleosidyl-ribonucleotide-RNA + diphosphate + H(+)"}
{"X":55559,"RHEA_ID":54200,"compounds":"N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":55560,"RHEA_ID":57545,"DIRECTION":"LR","MASTER_ID":57544,"metacyc":"RXN-19639","compounds":"(S)-beta-macrocarpene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + zealexin A1"}
{"X":55561,"RHEA_ID":57546,"compounds":"4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + zealexin A1 => (S)-beta-macrocarpene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]"}
{"X":55562,"RHEA_ID":57547,"compounds":"(S)-beta-macrocarpene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + zealexin A1"}
{"X":55563,"RHEA_ID":54204,"compounds":"2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 2 O2 = 2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine"}
{"X":55564,"RHEA_ID":60688,"compounds":"(11R)-dihydroartemisinic aldehyde + H2O + NAD(+) = (11R)-dihydroartemisinate + 2 H(+) + NADH"}
{"X":55565,"RHEA_ID":54206,"compounds":"2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 2 O2"}
{"X":55566,"RHEA_ID":57551,"compounds":"(S)-beta-macrocarpene + O2 + reduced [NADPH--hemoprotein reductase] <=> [(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":55567,"RHEA_ID":62367,"compounds":"FMNH2 + O2 + thymine <=> (Z)-2-methylureidoacrylate + FMN-N(5)-oxide + 2 H(+)"}
{"X":55568,"RHEA_ID":57553,"DIRECTION":"LR","MASTER_ID":57552,"metacyc":"RXN-12657","compounds":"[(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + O2 + reduced [NADPH--hemoprotein reductase] => (4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":55569,"RHEA_ID":57554,"compounds":"(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => [(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":55570,"RHEA_ID":57555,"compounds":"[(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + O2 + reduced [NADPH--hemoprotein reductase] <=> (4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":55571,"RHEA_ID":54212,"compounds":"2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 2 O2 = 2-(prostaglandin G2)-sn-glycero-3-phosphocholine"}
{"X":55572,"RHEA_ID":57557,"DIRECTION":"LR","MASTER_ID":57556,"metacyc":"RXN-12605","compounds":"(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + zealexin A1"}
{"X":55573,"RHEA_ID":54214,"compounds":"2-(prostaglandin G2)-sn-glycero-3-phosphocholine => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 2 O2"}
{"X":55574,"RHEA_ID":57559,"compounds":"(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + zealexin A1"}
{"X":55575,"RHEA_ID":54216,"compounds":"2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O"}
{"X":55576,"RHEA_ID":57561,"DIRECTION":"LR","MASTER_ID":57560,"metacyc":"RXN-19643","compounds":"(+)-cis-trans-nepetalactol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 7-deoxyloganetate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}
{"X":55577,"RHEA_ID":57562,"compounds":"7-deoxyloganetate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => (+)-cis-trans-nepetalactol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]"}
{"X":55578,"RHEA_ID":55324,"compounds":"11-cis-retinol + hexadecanoyl-CoA = 11-cis-retinyl hexadecanoate + CoA"}
{"X":55579,"RHEA_ID":54220,"DIRECTION":"UN","MASTER_ID":54220,"ec":"4.2.1.131","compounds":"1-hydroxy-all-trans-1,2-dihydro-neurosporene = all-trans-neurosporene + H2O"}
{"X":55580,"RHEA_ID":61151,"compounds":"myricetin 3-O-alpha-L-rhamnoside + UDP-alpha-D-glucose <=> H(+) + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] + UDP"}
{"X":55581,"RHEA_ID":58673,"compounds":"D-glucuronate => aldehydo-D-glucuronate"}
{"X":55582,"RHEA_ID":57567,"compounds":"(+)-cis-trans-nepetalactol + O2 + reduced [NADPH--hemoprotein reductase] <=> 7-deoxyloganetic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":55583,"RHEA_ID":54224,"compounds":"2-(prostaglandin H2)-sn-glycero-3-phosphocholine = 2-(prostaglandin E2)-sn-glycero-3-phosphocholine"}
{"X":55584,"RHEA_ID":54225,"compounds":"2-(prostaglandin H2)-sn-glycero-3-phosphocholine => 2-(prostaglandin E2)-sn-glycero-3-phosphocholine"}
{"X":55585,"RHEA_ID":54226,"compounds":"2-(prostaglandin E2)-sn-glycero-3-phosphocholine => 2-(prostaglandin H2)-sn-glycero-3-phosphocholine"}
{"X":55586,"RHEA_ID":57571,"compounds":"7-deoxyloganetic alcohol + O2 + reduced [NADPH--hemoprotein reductase] <=> 7-deoxyloganetic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":55587,"RHEA_ID":61158,"compounds":"CoA + GDP + H(+) => 3'-dephospho-CoA + GTP"}
{"X":55588,"RHEA_ID":54229,"compounds":"2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine => 2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine"}
{"X":55589,"RHEA_ID":58681,"compounds":"A + FADH2 => AH2 + FAD + H(+)"}
{"X":55590,"RHEA_ID":54231,"compounds":"2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine <=> 2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine"}
{"X":55591,"RHEA_ID":56473,"DIRECTION":"LR","MASTER_ID":56472,"metacyc":"RXN-19094","compounds":"(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 => (5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O"}
{"X":55592,"RHEA_ID":57577,"DIRECTION":"LR","MASTER_ID":57576,"metacyc":"RXN-4521","compounds":"7-deoxyloganate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + loganate + oxidized [NADPH--hemoprotein reductase]"}
{"X":55593,"RHEA_ID":58685,"compounds":"FAD + 2 H(+) + NADPH + O2 => FADH2-C4alpha-hydroperoxide + NADP(+)"}
{"X":55594,"RHEA_ID":55343,"compounds":"(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol <=> 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol + CoA"}
{"X":55595,"RHEA_ID":58687,"compounds":"FAD + 2 H(+) + NADPH + O2 <=> FADH2-C4alpha-hydroperoxide + NADP(+)"}
{"X":55596,"RHEA_ID":57581,"compounds":"5-methylsulfanyl-D-ribulose 1-phosphate => 1-methylsulfanyl-D-ribulose 5-phosphate"}
{"X":55597,"RHEA_ID":54238,"compounds":"1,2-didecanoyl-sn-glycero-3-phosphocholine + CMP + H(+) => 1,2-didecanoyl-sn-glycerol + CDP-choline"}
{"X":55598,"RHEA_ID":60263,"compounds":"L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine"}
{"X":55599,"RHEA_ID":58691,"compounds":"NADH + O2 + rifamycin SV <=> H2O + NAD(+) + rifamycin SV para-naphthoquinone carboxamide"}
{"X":55600,"RHEA_ID":57585,"compounds":"a flavanone + O2 + reduced [NADPH--hemoprotein reductase] => a 2-hydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":55601,"RHEA_ID":54242,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-choline"}
{"X":55602,"RHEA_ID":58694,"compounds":"FADH2 + H2O + NAD(+) + rifamycin SV hemiaminal => FADH2-C4alpha-hydroperoxide + H(+) + NADH + rifamycin SV"}
{"X":55603,"RHEA_ID":58695,"compounds":"FADH2-C4alpha-hydroperoxide + H(+) + NADH + rifamycin SV <=> FADH2 + H2O + NAD(+) + rifamycin SV hemiaminal"}
{"X":55604,"RHEA_ID":61175,"compounds":"myricetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose <=> H(+) + myricetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP"}
{"X":55605,"RHEA_ID":54246,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline"}
{"X":55606,"RHEA_ID":57591,"compounds":"(S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] <=> (2S)-2-hydroxynaringenin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":55607,"RHEA_ID":54248,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)"}
{"X":55608,"RHEA_ID":61179,"compounds":"(E)-caffeoyl-CoA + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside <=> CoA + H(+) + quercetin 3-O-[(6-O-[(E)-caffeoyl]-beta-D-glucosyl)-(1->2)-beta-D-glucoside]"}
{"X":55609,"RHEA_ID":61579,"compounds":"(4R,5R)-4,5-dihydroxycyclohex-2-ene-1-carbonyl-CoA + NADP(+) <=> (3R,4R)-3,4-dihydroxycyclohexa-1,5-diene-1-carbonyl-CoA + H(+) + NADPH"}
{"X":55610,"RHEA_ID":57595,"compounds":"(S)-pinocembrin + O2 + reduced [NADPH--hemoprotein reductase] <=> (2S)-2-hydroxypinocembrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":55611,"RHEA_ID":59885,"compounds":"2-oxoglutarate + chloride + H(+) + L-lysine + O2 => 4-chloro-L-lysine + CO2 + H2O + succinate"}
{"X":55612,"RHEA_ID":58704,"compounds":"rifampicin hemiaminal = rifampicin ortho-naphthoquinone carboxamide"}
{"X":55613,"RHEA_ID":54254,"compounds":"1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine"}
{"X":55614,"RHEA_ID":57599,"compounds":"(S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase] <=> (2S)-2-hydroxyeriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":55615,"RHEA_ID":57600,"DIRECTION":"UN","MASTER_ID":57600,"ec":"1.14.19.75","compounds":"2 [Fe(II)-cytochrome b5] + a 1-hexacosanoyl-2-acyl-phosphoglycerolipid + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + a 1-[(17Z)-hexacos-17-enoyl]-2-acyl-phosphoglycerolipid + 2 H2O"}
{"X":55616,"RHEA_ID":54257,"compounds":"2-oxoglutarate + L-histidyl-[protein] + O2 => (3S)-3-hydroxy-L-histidyl-[protein] + CO2 + succinate"}
{"X":55617,"RHEA_ID":54258,"compounds":"(3S)-3-hydroxy-L-histidyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-histidyl-[protein] + O2"}
{"X":55618,"RHEA_ID":54259,"compounds":"2-oxoglutarate + L-histidyl-[protein] + O2 <=> (3S)-3-hydroxy-L-histidyl-[protein] + CO2 + succinate"}
{"X":55619,"RHEA_ID":58711,"compounds":"rifampicin ortho-naphthoquinone carboxamide <=> rifampicin para-naphthoquinone carboxamide"}
{"X":55620,"RHEA_ID":57605,"DIRECTION":"LR","MASTER_ID":57604,"metacyc":"RXN-16237","compounds":"2 [Fe(II)-cytochrome b5] + a 1-tetracosanoyl-2-acyl-phosphoglycerolipid + 2 H(+) + O2 => 2 [Fe(III)-cytochrome b5] + a 1-[(15Z)-tetracos-15-enoyl]-2-acyl-phosphoglycerolipid + 2 H2O"}
{"X":55621,"RHEA_ID":54262,"compounds":"(3S)-3-hydroxy-L-asparaginyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-asparaginyl-[protein] + O2"}
{"X":55622,"RHEA_ID":62517,"compounds":"beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-galactosamine => H(+) + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + UDP"}
{"X":55623,"RHEA_ID":58715,"compounds":"NADH + O2 + rifampicin <=> H(+) + H2O + NAD(+) + rifampicin para-naphthoquinone carboxamide"}
{"X":55624,"RHEA_ID":57609,"DIRECTION":"LR","MASTER_ID":57608,"metacyc":"RXN-9859","compounds":"(1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+) => 3-chlorocatechol + H(+) + NADH"}
{"X":55625,"RHEA_ID":57610,"compounds":"3-chlorocatechol + H(+) + NADH => (1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+)"}
{"X":55626,"RHEA_ID":58718,"compounds":"FADH2 + H(+) + H2O + NAD(+) + rifampicin hemiaminal => FADH2-C4alpha-hydroperoxide + NADH + rifampicin"}
{"X":55627,"RHEA_ID":54268,"DIRECTION":"UN","MASTER_ID":54268,"ec":"1.14.11.30","compounds":"2-oxoglutarate + [hypoxia-inducible factor alpha subunit]-L-asparagine + O2 = [hypoxia-inducible factor alpha subunit]-(3S)-3-hydroxy-L-asparagine + CO2 + succinate"}
{"X":55628,"RHEA_ID":54269,"DIRECTION":"LR","MASTER_ID":54268,"metacyc":"RXN-11321","compounds":"2-oxoglutarate + [hypoxia-inducible factor alpha subunit]-L-asparagine + O2 => [hypoxia-inducible factor alpha subunit]-(3S)-3-hydroxy-L-asparagine + CO2 + succinate"}
{"X":55629,"RHEA_ID":54270,"compounds":"[hypoxia-inducible factor alpha subunit]-(3S)-3-hydroxy-L-asparagine + CO2 + succinate => 2-oxoglutarate + [hypoxia-inducible factor alpha subunit]-L-asparagine + O2"}
{"X":55630,"RHEA_ID":61201,"compounds":"acetyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] => CoA + myricetin 3-O-[(6-O-acetyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]"}
{"X":55631,"RHEA_ID":57616,"compounds":"dihydro-ML-236C-[compactin nonaketide synthase] + H2O = dihydro-ML-236C carboxylate + H(+) + holo-[compactin nonaketide synthase]"}
{"X":55632,"RHEA_ID":57617,"compounds":"dihydro-ML-236C-[compactin nonaketide synthase] + H2O => dihydro-ML-236C carboxylate + H(+) + holo-[compactin nonaketide synthase]"}
{"X":55633,"RHEA_ID":54274,"compounds":"(3S)-3-hydroxy-L-asparaginyl-[ankyrin-repeat domain protein] + CO2 + succinate => 2-oxoglutarate + L-asparaginyl-[ankyrin-repeat domain protein] + O2"}
{"X":55634,"RHEA_ID":61205,"compounds":"L-arginyl-[protein] + L-cysteinyl-[protein] + methylglyoxal => H(+) + 2 H2O + N(5)-[4-(S-L-cysteinyl-[protein])-5-methyl-1H-imidazol-2-yl]-L-ornithinyl-[protein]"}
{"X":55635,"RHEA_ID":60300,"compounds":"N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":55636,"RHEA_ID":57621,"compounds":"dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + ML-236C carboxylate + oxidized [NADPH--hemoprotein reductase]"}
{"X":55637,"RHEA_ID":54278,"compounds":"(3S)-3-hydroxy-L-aspartyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-aspartyl-[protein] + O2"}
{"X":55638,"RHEA_ID":62534,"compounds":"2 [Fe(III)cytochrome c] + dihydrodigitoxin => 2 [Fe(II)cytochrome c] + digitoxin + 3 H(+)"}
{"X":55639,"RHEA_ID":61209,"compounds":"8-nitro-cGMP + L-cysteinyl-[protein] => H(+) + nitrite + S-(guanosine 3',5'-cyclic phosphate)-L-cysteinyl-[protein]"}
{"X":55640,"RHEA_ID":54281,"compounds":"2-oxoglutarate + L-aspartyl-[ankyrin-repeat domain protein] + O2 => (3S)-3-hydroxy-L-aspartyl-[ankyrin-repeat domain protein] + CO2 + succinate"}
{"X":55641,"RHEA_ID":54282,"compounds":"(3S)-3-hydroxy-L-aspartyl-[ankyrin-repeat domain protein] + CO2 + succinate => 2-oxoglutarate + L-aspartyl-[ankyrin-repeat domain protein] + O2"}
{"X":55642,"RHEA_ID":62538,"compounds":"2 [Fe(III)cytochrome c] + dihydrodigoxigenin => 2 [Fe(II)cytochrome c] + digoxigenin + 3 H(+)"}
{"X":55643,"RHEA_ID":62537,"compounds":"2 [Fe(II)cytochrome c] + digoxigenin + 3 H(+) => 2 [Fe(III)cytochrome c] + dihydrodigoxigenin"}
{"X":55644,"RHEA_ID":54285,"compounds":"H2O + N-(octadecanoyl)-sphing-4-enine-1-phosphocholine => H(+) + N-octadecanoylsphing-4-enine + phosphocholine"}
{"X":55645,"RHEA_ID":54286,"compounds":"H(+) + N-octadecanoylsphing-4-enine + phosphocholine => H2O + N-(octadecanoyl)-sphing-4-enine-1-phosphocholine"}
{"X":55646,"RHEA_ID":61217,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + 1D-myo-inositol 3-phosphate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)"}
{"X":55647,"RHEA_ID":61218,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + 1D-myo-inositol 3-phosphate"}
{"X":55648,"RHEA_ID":54289,"compounds":"ATP + L-tyrosyl-[protein] => diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein]"}
{"X":55649,"RHEA_ID":54290,"compounds":"diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein] => ATP + L-tyrosyl-[protein]"}
{"X":55650,"RHEA_ID":62546,"compounds":"2 [Fe(III)cytochrome c] + dihydroouabagenin => 2 [Fe(II)cytochrome c] + 3 H(+) + ouabagenin"}
{"X":55651,"RHEA_ID":54292,"DIRECTION":"UN","MASTER_ID":54292,"ec":"2.7.7.n1","compounds":"ATP + L-threonyl-[protein] = 3-O-(5'-adenylyl)-L-threonyl-[protein] + diphosphate"}
{"X":55652,"RHEA_ID":54293,"compounds":"ATP + L-threonyl-[protein] => 3-O-(5'-adenylyl)-L-threonyl-[protein] + diphosphate"}
{"X":55653,"RHEA_ID":55406,"compounds":"[phosphate](n+1) + UDP => [phosphate](n) + UTP"}
{"X":55654,"RHEA_ID":61225,"compounds":"H2O + L-asparagine + O2 => 2-oxosuccinamate + H2O2 + NH4(+)"}
{"X":55655,"RHEA_ID":61226,"compounds":"2-oxosuccinamate + H2O2 + NH4(+) => H2O + L-asparagine + O2"}
{"X":55656,"RHEA_ID":61227,"compounds":"H2O + L-asparagine + O2 <=> 2-oxosuccinamate + H2O2 + NH4(+)"}
{"X":55657,"RHEA_ID":54298,"compounds":"diphosphate + O-(5'-guanylyl)-L-tyrosyl-[protein] => GTP + L-tyrosyl-[protein]"}
{"X":55658,"RHEA_ID":62554,"compounds":"beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H(+) + UDP => beta-D-glucosylceramide + UDP-alpha-D-galactose"}
{"X":55659,"RHEA_ID":58751,"compounds":"desmethylnectriapyrone + S-adenosyl-L-methionine <=> H(+) + nectriapyrone + S-adenosyl-L-homocysteine"}
{"X":55660,"RHEA_ID":57645,"DIRECTION":"LR","MASTER_ID":57644,"metacyc":"RXN-16693","compounds":"(3-{(1R,2S,6S,8R)-2,8-dimethyl-3-[(E)-prop-1-enyl]-4,5-didehydrodecalin-2-yl}-3-oxopropanoyl)-[equisetin nonaketide synthase] + L-serine => H(+) + H2O + holo-[equisetin nonaketide synthase] + trichosetin"}
{"X":55661,"RHEA_ID":57646,"compounds":"H(+) + H2O + holo-[equisetin nonaketide synthase] + trichosetin => (3-{(1R,2S,6S,8R)-2,8-dimethyl-3-[(E)-prop-1-enyl]-4,5-didehydrodecalin-2-yl}-3-oxopropanoyl)-[equisetin nonaketide synthase] + L-serine"}
{"X":55662,"RHEA_ID":58754,"compounds":"1-hexadecanoyl-2-(7-hydroxyheptanoyl)-sn-glycero-3-phosphocholine + NADP(+) => 1-hexadecanoyl-2-(7-oxoheptanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH"}
{"X":55663,"RHEA_ID":61234,"compounds":"(S)-3-methyl-2-oxopentanoate + H2O2 + NH4(+) => H2O + L-isoleucine + O2"}
{"X":55664,"RHEA_ID":55417,"DIRECTION":"LR","MASTER_ID":55416,"metacyc":"RXN-4702","compounds":"biochanin A + UDP-alpha-D-glucose => biochanin A 7-O-beta-D-glucoside + H(+) + UDP"}
{"X":55665,"RHEA_ID":57654,"compounds":"CMP + ganglioside GM1alpha + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GA1"}
{"X":55666,"RHEA_ID":61237,"compounds":"H2O + L-methionine + O2 => 4-methylsulfanyl-2-oxobutanoate + H2O2 + NH4(+)"}
{"X":55667,"RHEA_ID":61238,"compounds":"4-methylsulfanyl-2-oxobutanoate + H2O2 + NH4(+) => H2O + L-methionine + O2"}
{"X":55668,"RHEA_ID":54309,"DIRECTION":"LR","MASTER_ID":54308,"metacyc":"RXN-13327","compounds":"pseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-homocysteine"}
{"X":55669,"RHEA_ID":57658,"compounds":"CMP + ganglioside GT1balpha + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GD1b"}
{"X":55670,"RHEA_ID":61241,"DIRECTION":"LR","MASTER_ID":61240,"reactome":"R-HSA-2160492.2","compounds":"H2O + L-phenylalanine + O2 => 3-phenylpyruvate + H2O2 + NH4(+)"}
{"X":55671,"RHEA_ID":58763,"compounds":"1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + NADPH <=> 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + NADP(+)"}
{"X":55672,"RHEA_ID":57661,"DIRECTION":"LR","MASTER_ID":57660,"metacyc":"RXN-19789","compounds":"(+)-valencene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (+)-nootkatone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":55673,"RHEA_ID":57662,"compounds":"(+)-nootkatone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => (+)-valencene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}
{"X":55674,"RHEA_ID":61245,"compounds":"H2O + L-tryptophan + O2 => H2O2 + indole-3-pyruvate + NH4(+)"}
{"X":55675,"RHEA_ID":54324,"DIRECTION":"UN","MASTER_ID":54324,"ec":"1.3.7.11","compounds":"a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid + 16 oxidized [2Fe-2S]-[ferredoxin] = a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 16 H(+) + 16 reduced [2Fe-2S]-[ferredoxin]"}
{"X":55676,"RHEA_ID":58768,"compounds":"1-O-(1Z-hexadecenyl)-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH = 1-O-(1Z-hexadecenyl)-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)"}
{"X":55677,"RHEA_ID":57666,"compounds":"alpha-nootkatol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-valencene + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":55678,"RHEA_ID":61249,"DIRECTION":"LR","MASTER_ID":61248,"metacyc":"RXN-12487","compounds":"H2O + L-tyrosine + O2 => 3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+)"}
{"X":55679,"RHEA_ID":61250,"compounds":"3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+) => H2O + L-tyrosine + O2"}
{"X":55680,"RHEA_ID":58772,"compounds":"1-O-hexadecyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH = 1-O-hexadecyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)"}
{"X":55681,"RHEA_ID":57670,"compounds":"(+)-nootkatone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => alpha-nootkatol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":55682,"RHEA_ID":61253,"compounds":"H2O + L-valine + O2 => 3-methyl-2-oxobutanoate + H2O2 + NH4(+)"}
{"X":55683,"RHEA_ID":62586,"compounds":"ADP + H(+) + L-tyrosine(in) + phosphate => ATP + H2O + L-tyrosine(out)"}
{"X":55684,"RHEA_ID":61255,"compounds":"H2O + L-valine + O2 <=> 3-methyl-2-oxobutanoate + H2O2 + NH4(+)"}
{"X":55685,"RHEA_ID":57674,"compounds":"2beta-hydroxy-5-epi-aristolochene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-5-epi-aristolochene + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":55686,"RHEA_ID":62590,"compounds":"4-hydroxybenzyl alcohol + CO2 => 2-hydroxy-2-(4-hydroxyphenyl)acetate + H(+)"}
{"X":55687,"RHEA_ID":55440,"DIRECTION":"UN","MASTER_ID":55440,"ec":"1.14.14.63","compounds":"beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + maniladiol + oxidized [NADPH--hemoprotein reductase]"}
{"X":55688,"RHEA_ID":55441,"DIRECTION":"LR","MASTER_ID":55440,"metacyc":"RXN-15385","compounds":"beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + maniladiol + oxidized [NADPH--hemoprotein reductase]"}
{"X":55689,"RHEA_ID":57678,"compounds":"4-epi-eremophilene-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 4-epi-eremophilene + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":55690,"RHEA_ID":61261,"compounds":"H2O + L-glutamine + O2 => 2-oxoglutaramate + H2O2 + NH4(+)"}
{"X":55691,"RHEA_ID":61262,"compounds":"2-oxoglutaramate + H2O2 + NH4(+) => H2O + L-glutamine + O2"}
{"X":55692,"RHEA_ID":61263,"compounds":"H2O + L-glutamine + O2 <=> 2-oxoglutaramate + H2O2 + NH4(+)"}
{"X":55693,"RHEA_ID":57682,"compounds":"a flavone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => a flavanone + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":55694,"RHEA_ID":55447,"compounds":"O2 + oleanolate + reduced [NADPH--hemoprotein reductase] <=> cochalate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":55695,"RHEA_ID":54344,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)"}
{"X":55696,"RHEA_ID":61267,"compounds":"H2O + L-alanine + O2 <=> H2O2 + NH4(+) + pyruvate"}
{"X":55697,"RHEA_ID":57690,"compounds":"cob(II)inamide--[corrinoid adenosyltransferase] => apo-[corrinoid adenosyltransferase] + cob(II)inamide"}
{"X":55698,"RHEA_ID":61269,"compounds":"H2O + L-2-aminohexanoate + O2 => 2-oxohexanoate + H2O2 + NH4(+)"}
{"X":55699,"RHEA_ID":54348,"compounds":"1-O-hexadecyl-2-acetyl-sn-glycerol + CDP-choline = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+)"}
{"X":55700,"RHEA_ID":57693,"compounds":"2 cob(II)inamide--[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] => 2 cob(I)inamide--[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":55701,"RHEA_ID":58797,"compounds":"a flavonol 7-O-beta-D-glucoside + malonyl-CoA => a flavonol 7-O-(6-O-malonyl-beta-D-glucoside) + CoA"}
{"X":55702,"RHEA_ID":58798,"compounds":"a flavonol 7-O-(6-O-malonyl-beta-D-glucoside) + CoA => a flavonol 7-O-beta-D-glucoside + malonyl-CoA"}
{"X":55703,"RHEA_ID":55456,"DIRECTION":"UN","MASTER_ID":55456,"ec":"1.14.14.65","compounds":"ferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + sugiol"}
{"X":55704,"RHEA_ID":57697,"compounds":"ATP + cob(I)inamide--[corrinoid adenosyltransferase] => adenosylcob(III)inamide + apo-[corrinoid adenosyltransferase] + triphosphate"}
{"X":55705,"RHEA_ID":54354,"compounds":"1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CMP + H(+) => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline"}
{"X":55706,"RHEA_ID":58802,"compounds":"5'-pApG-3' + H(+) => 3',3'-cGAMP + H2O"}
{"X":55707,"RHEA_ID":57700,"DIRECTION":"UN","MASTER_ID":57700,"ec":"2.1.1.350","compounds":"a 2-demethylmenaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine = 5'-deoxyadenosine + a 2-demethyl-8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine"}
{"X":55708,"RHEA_ID":54357,"DIRECTION":"LR","MASTER_ID":54356,"metacyc":"RXN-7643","compounds":"3-methyl-2-oxobutanoate + H(+) => 2-methylpropanal + CO2"}
{"X":55709,"RHEA_ID":57702,"compounds":"5'-deoxyadenosine + a 2-demethyl-8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine => a 2-demethylmenaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine"}
{"X":55710,"RHEA_ID":58806,"compounds":"5'-ApG-3' + phosphate => 5'-pApG-3' + H2O"}
{"X":55711,"RHEA_ID":57704,"DIRECTION":"UN","MASTER_ID":57704,"ec":"1.1.1.237","compounds":"(2R)-3-(3,4-dihydroxyphenyl)lactate + NADP(+) = 3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADPH"}
{"X":55712,"RHEA_ID":54361,"DIRECTION":"LR","MASTER_ID":54360,"metacyc":"RXN-7692","compounds":"4-methyl-2-oxopentanoate + H(+) => 3-methylbutanal + CO2"}
{"X":55713,"RHEA_ID":57706,"DIRECTION":"RL","MASTER_ID":57704,"ecocyc":"RXN-7632","metacyc":"RXN-7632","compounds":"3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADPH => (2R)-3-(3,4-dihydroxyphenyl)lactate + NADP(+)"}
{"X":55714,"RHEA_ID":61285,"compounds":"H2O + L-cystine + O2 => (2R)-2-amino-2-carboxylatoethyl-disulfanyl-oxopropanoate + H2O2 + NH4(+)"}
{"X":55715,"RHEA_ID":57708,"DIRECTION":"UN","MASTER_ID":57708,"metacyc":"RXN-91","compounds":"(E)-coniferaldehyde + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-4-trans-coniferyl aldehyde + H(+) + UDP"}
{"X":55716,"RHEA_ID":57709,"compounds":"(E)-coniferaldehyde + UDP-alpha-D-glucose => 4-O-(beta-D-glucosyl)-4-trans-coniferyl aldehyde + H(+) + UDP"}
{"X":55717,"RHEA_ID":57710,"compounds":"4-O-(beta-D-glucosyl)-4-trans-coniferyl aldehyde + H(+) + UDP => (E)-coniferaldehyde + UDP-alpha-D-glucose"}
{"X":55718,"RHEA_ID":58814,"compounds":"AMP + diphosphate + H(+) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate => ATP + H2O + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate"}
{"X":55719,"RHEA_ID":57712,"compounds":"(E)-sinapoaldehyde + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-4-trans-sinapoyl aldehyde + H(+) + UDP"}
{"X":55720,"RHEA_ID":54369,"DIRECTION":"LR","MASTER_ID":54368,"ecocyc":"RXN0-2022","metacyc":"RXN0-2022","compounds":"acetaldehyde + H(+) + pyruvate => acetoin + CO2"}
{"X":55721,"RHEA_ID":57714,"compounds":"4-O-(beta-D-glucosyl)-4-trans-sinapoyl aldehyde + H(+) + UDP => (E)-sinapoaldehyde + UDP-alpha-D-glucose"}
{"X":55722,"RHEA_ID":54739,"compounds":"N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine"}
{"X":55723,"RHEA_ID":57716,"compounds":"hydrogencarbonate + NH4(+) = carbamate + H(+) + H2O"}
{"X":55724,"RHEA_ID":61295,"compounds":"(R)-pantoate + NAD(+) <=> 2-dehydropantoate + H(+) + NADH"}
{"X":55725,"RHEA_ID":57718,"compounds":"carbamate + H(+) + H2O => hydrogencarbonate + NH4(+)"}
{"X":55726,"RHEA_ID":55479,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + N-acyleicosasphinganine + O2 <=> 2 [Fe(III)-cytochrome b5] + H2O + N-acyl-4-hydroxyeicosasphinganine"}
{"X":55727,"RHEA_ID":58823,"compounds":"H(+) + malonate + Na(+)(in) <=> acetate + CO2 + Na(+)(out)"}
{"X":55728,"RHEA_ID":57721,"compounds":"ATP + 4 H(+)(in) + H2O => ADP + 5 H(+)(out) + phosphate"}
{"X":55729,"RHEA_ID":57722,"compounds":"ADP + 5 H(+)(out) + phosphate => ATP + 4 H(+)(in) + H2O"}
{"X":55730,"RHEA_ID":58826,"compounds":"aureothin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => 4 H(+) + luteothin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]"}
{"X":55731,"RHEA_ID":57724,"DIRECTION":"UN","MASTER_ID":57724,"ec":"7.2.4.2","compounds":"H(+) + 2 Na(+)(in) + oxaloacetate = CO2 + 2 Na(+)(out) + pyruvate"}
{"X":55732,"RHEA_ID":54381,"DIRECTION":"LR","MASTER_ID":54380,"metacyc":"RXN-18889","compounds":"(2E,6E)-farnesyl diphosphate + H2O => 5-hydroxy-alpha-gurjunene + diphosphate"}
{"X":55733,"RHEA_ID":55485,"DIRECTION":"LR","MASTER_ID":55484,"metacyc":"RXN-15462","compounds":"ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":55734,"RHEA_ID":58830,"compounds":"9R,10R-dihydroxyoctadecanoate => (9S,10R)-epoxy-octadecanoate + H2O"}
{"X":55735,"RHEA_ID":57728,"DIRECTION":"UN","MASTER_ID":57728,"ec":"4.1.1.113","compounds":"H(+) + trans-aconitate = CO2 + itaconate"}
{"X":55736,"RHEA_ID":54385,"compounds":"a 3-oxo-5alpha-steroid + NADP(+) => a 3-oxo-Delta(4)-steroid + H(+) + NADPH"}
{"X":55737,"RHEA_ID":58833,"DIRECTION":"LR","MASTER_ID":58832,"metacyc":"RXN-19720","compounds":"24-methylenecycloartanol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}
{"X":55738,"RHEA_ID":58834,"compounds":"4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O => 24-methylenecycloartanol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2"}
{"X":55739,"RHEA_ID":60416,"DIRECTION":"UN","MASTER_ID":60416,"ec":"3.1.1.107","compounds":"diglucosyl-enterobactin + H2O = H(+) + N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2"}
{"X":55740,"RHEA_ID":59625,"compounds":"H2O + N(2)-(4-aminobutanoyl)-L-ornithine => 4-aminobutanoate + L-ornithine"}
{"X":55741,"RHEA_ID":58464,"compounds":"a neolactoside nLc4Cer + UDP-N-acetyl-alpha-D-glucosamine = a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + H(+) + UDP"}
{"X":55742,"RHEA_ID":54391,"compounds":"1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate"}
{"X":55743,"RHEA_ID":58839,"compounds":"24-methylenecycloartanol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":55744,"RHEA_ID":57737,"compounds":"A + all-trans-3,4-didehydro-13,14-dihydroretinol => AH2 + all-trans-3,4-didehydroretinol"}
{"X":55745,"RHEA_ID":57738,"compounds":"AH2 + all-trans-3,4-didehydroretinol => A + all-trans-3,4-didehydro-13,14-dihydroretinol"}
{"X":55746,"RHEA_ID":54395,"compounds":"1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z)-octadecadienoate + 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+)"}
{"X":55747,"RHEA_ID":57740,"DIRECTION":"UN","MASTER_ID":57740,"ec":"1.3.1.118","compounds":"a 2,3-saturated meromycolyl-[ACP] + NAD(+) = a trans-Delta(2)-meromycolyl-[ACP] + H(+) + NADH"}
{"X":55748,"RHEA_ID":57741,"compounds":"a 2,3-saturated meromycolyl-[ACP] + NAD(+) => a trans-Delta(2)-meromycolyl-[ACP] + H(+) + NADH"}
{"X":55749,"RHEA_ID":57742,"DIRECTION":"RL","MASTER_ID":57740,"metacyc":"RXN-18468","compounds":"a trans-Delta(2)-meromycolyl-[ACP] + H(+) + NADH => a 2,3-saturated meromycolyl-[ACP] + NAD(+)"}
{"X":55750,"RHEA_ID":54399,"compounds":"1-tetradecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate"}
{"X":55751,"RHEA_ID":62679,"compounds":"10-formyldihydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-thiocarboxamide <=> 6-thio-IMP + 7,8-dihydrofolate + H2O"}
{"X":55752,"RHEA_ID":54401,"compounds":"1-tetradecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O => 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate"}
{"X":55753,"RHEA_ID":57746,"DIRECTION":"RL","MASTER_ID":57744,"metacyc":"RXN-19672","compounds":"[protein]-dithiol + phylloquinone => [protein]-disulfide + phylloquinol"}
{"X":55754,"RHEA_ID":54403,"compounds":"1-tetradecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate"}
{"X":55755,"RHEA_ID":62683,"compounds":"YWA1 <=> H(+) + H2O + norrubrofusarin"}
{"X":55756,"RHEA_ID":57749,"DIRECTION":"LR","MASTER_ID":57748,"metacyc":"RXN-17224","compounds":"2 (S)-methylmalonyl-CoA + 10 H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 3 malonyl-CoA + 5 NADPH => C32-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)"}
{"X":55757,"RHEA_ID":57750,"compounds":"C32-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+) => 2 (S)-methylmalonyl-CoA + 10 H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 3 malonyl-CoA + 5 NADPH"}
{"X":55758,"RHEA_ID":55510,"compounds":"11-oxocucurbitadienol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => cucurbitadienol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}
{"X":55759,"RHEA_ID":54408,"compounds":"1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)"}
{"X":55760,"RHEA_ID":61331,"compounds":"O2 + parthenolide + reduced [NADPH--hemoprotein reductase] <=> 3beta-hydroxyparthenolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":55761,"RHEA_ID":58857,"compounds":"(6E)-8-hydroxygeraniol + NAD(+) => (6E)-8-oxogeraniol + H(+) + NADH"}
{"X":55762,"RHEA_ID":54411,"compounds":"1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)"}
{"X":55763,"RHEA_ID":57756,"DIRECTION":"UN","MASTER_ID":57756,"ec":"2.3.1.292","compounds":"2 (S)-methylmalonyl-CoA + 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH = C35-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)"}
{"X":55764,"RHEA_ID":61335,"compounds":"ATP + H2O + indoxyl sulfate(in) <=> ADP + H(+) + indoxyl sulfate(out) + phosphate"}
{"X":55765,"RHEA_ID":56646,"compounds":"a pseudouridine in mRNA => a uridine in mRNA"}
{"X":55766,"RHEA_ID":55518,"compounds":"11-oxocucurbitadienol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 11-hydroxycucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":55767,"RHEA_ID":58862,"compounds":"4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}
{"X":55768,"RHEA_ID":61339,"compounds":"ATP + H2O + protoporphyrin IX(in) <=> ADP + H(+) + phosphate + protoporphyrin IX(out)"}
{"X":55769,"RHEA_ID":55925,"DIRECTION":"LR","MASTER_ID":55924,"metacyc":"RXN-19041","compounds":"albendazole + O2 + reduced [NADPH--hemoprotein reductase] => albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":55770,"RHEA_ID":60060,"compounds":"a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose = alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP"}
{"X":55771,"RHEA_ID":62710,"compounds":"4-(indol-3-yl)butanoyl-beta-D-glucose + UDP => (indol-3-yl)butanoate + UDP-alpha-D-glucose"}
{"X":55772,"RHEA_ID":57765,"DIRECTION":"LR","MASTER_ID":57764,"metacyc":"RXN-8825","compounds":"2,6-dinitrotoluene + NADH + O2 => 3-methyl-4-nitrocatechol + NAD(+) + nitrite"}
{"X":55773,"RHEA_ID":57766,"compounds":"3-methyl-4-nitrocatechol + NAD(+) + nitrite => 2,6-dinitrotoluene + NADH + O2"}
{"X":55774,"RHEA_ID":54423,"compounds":"3',3'-c-di-AMP + H2O <=> 5'-O-phosphonoadenylyl-(3'->5')-adenosine + H(+)"}
{"X":55775,"RHEA_ID":58871,"compounds":"24-methylidenelophenol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}
{"X":55776,"RHEA_ID":61347,"compounds":"H2O + L-serine + O2 <=> 3-hydroxypyruvate + H2O2 + NH4(+)"}
{"X":55777,"RHEA_ID":60066,"compounds":"a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + H2O + NAD(+) => a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + NADH + O2"}
{"X":55778,"RHEA_ID":54427,"compounds":"L-aspartyl-[protein] + NAD(+) <=> 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide"}
{"X":55779,"RHEA_ID":61350,"compounds":"ADP + estrone 3-sulfate(out) + H(+) + phosphate => ATP + estrone 3-sulfate(in) + H2O"}
{"X":55780,"RHEA_ID":57773,"DIRECTION":"LR","MASTER_ID":57772,"metacyc":"RXN-8814","compounds":"3-nitrotoluene + NADH + O2 => 4-methylcatechol + NAD(+) + nitrite"}
{"X":55781,"RHEA_ID":57774,"compounds":"4-methylcatechol + NAD(+) + nitrite => 3-nitrotoluene + NADH + O2"}
{"X":55782,"RHEA_ID":54431,"compounds":"4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + H2O <=> ADP-D-ribose + H(+) + L-aspartyl-[protein]"}
{"X":55783,"RHEA_ID":58879,"compounds":"4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":55784,"RHEA_ID":57777,"compounds":"2-chloro-6-nitrotoluene + NADH + O2 => 4-chloro-3-methylcatechol + NAD(+) + nitrite"}
{"X":55785,"RHEA_ID":57778,"compounds":"4-chloro-3-methylcatechol + NAD(+) + nitrite => 2-chloro-6-nitrotoluene + NADH + O2"}
{"X":55786,"RHEA_ID":55538,"compounds":"a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+) => an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose"}
{"X":55787,"RHEA_ID":58883,"compounds":"4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":55788,"RHEA_ID":61359,"compounds":"ATP + H2O + methotrexate(in) <=> ADP + H(+) + methotrexate(out) + phosphate"}
{"X":55789,"RHEA_ID":57782,"compounds":"3-chloro-4-methylcatechol + NAD(+) + nitrite => 2-chloro-4-nitrotoluene + NADH + O2"}
{"X":55790,"RHEA_ID":61361,"compounds":"ATP + H2O + pheophorbide a(in) => ADP + H(+) + pheophorbide a(out) + phosphate"}
{"X":55791,"RHEA_ID":57784,"DIRECTION":"UN","MASTER_ID":57784,"ec":"1.14.12.23","metacyc":"RXN-16801","compounds":"1,4-dinitrobenzene + NADH + O2 = 4-nitrocatechol + H(+) + NAD(+) + nitrite"}
{"X":55792,"RHEA_ID":57785,"compounds":"1,4-dinitrobenzene + NADH + O2 => 4-nitrocatechol + H(+) + NAD(+) + nitrite"}
{"X":55793,"RHEA_ID":55545,"compounds":"L-lysyl-[citrate synthase] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine"}
{"X":55794,"RHEA_ID":54443,"compounds":"a (4S)-2,3-dehydroflavan-3,4-diol + H(+) <=> a 4-H-anthocyanidin with a 3-hydroxy group + H2O"}
{"X":55795,"RHEA_ID":61366,"compounds":"3beta-sulfooxy-androst-5-en-17-one(out) + ADP + H(+) + phosphate => 3beta-sulfooxy-androst-5-en-17-one(in) + ATP + H2O"}
{"X":55796,"RHEA_ID":57789,"compounds":"1,3-dinitrobenzene + NADH + O2 => 4-nitrocatechol + H(+) + NAD(+) + nitrite"}
{"X":55797,"RHEA_ID":57790,"compounds":"4-nitrocatechol + H(+) + NAD(+) + nitrite => 1,3-dinitrobenzene + NADH + O2"}
{"X":55798,"RHEA_ID":61369,"compounds":"4-methylumbelliferone sulfate(in) + ATP + H2O => 4-methylumbelliferone sulfate(out) + ADP + H(+) + phosphate"}
{"X":55799,"RHEA_ID":61370,"compounds":"4-methylumbelliferone sulfate(out) + ADP + H(+) + phosphate => 4-methylumbelliferone sulfate(in) + ATP + H2O"}
{"X":55800,"RHEA_ID":54449,"DIRECTION":"LR","MASTER_ID":54448,"ecocyc":"AMINOCYL-TRNA-HYDROLASE-RXN","metacyc":"AMINOCYL-TRNA-HYDROLASE-RXN","compounds":"H2O + N-acyl-L-alpha-aminoacyl-tRNA => an N-acyl-L-amino acid + H(+) + tRNA"}
{"X":55801,"RHEA_ID":54450,"compounds":"an N-acyl-L-amino acid + H(+) + tRNA => H2O + N-acyl-L-alpha-aminoacyl-tRNA"}
{"X":55802,"RHEA_ID":57796,"DIRECTION":"UN","MASTER_ID":57796,"ec":"1.14.12.23","metacyc":"RXN-16798","compounds":"4-nitrotoluene + NADH + O2 = 4-methylcatechol + NAD(+) + nitrite"}
{"X":55803,"RHEA_ID":58908,"DIRECTION":"UN","MASTER_ID":58908,"ec":"2.3.1.287","compounds":"7 (S)-methylmalonyl-CoA + 21 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 14 NADPH = C37-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 7 CO2 + 7 CoA + 7 H2O + 14 NADP(+)"}
{"X":55804,"RHEA_ID":54454,"compounds":"a uridine in tRNA + H(+) + NADH => a 5,6-dihydrouridine in tRNA + NAD(+)"}
{"X":55805,"RHEA_ID":54455,"compounds":"a 5,6-dihydrouridine in tRNA + NAD(+) <=> a uridine in tRNA + H(+) + NADH"}
{"X":55806,"RHEA_ID":54456,"compounds":"1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate"}
{"X":55807,"RHEA_ID":58912,"DIRECTION":"UN","MASTER_ID":58912,"ec":"7.2.2.18","compounds":"ATP + H2O + iron(III) dicitrate(out) = ADP + H(+) + iron(III) dicitrate(in) + phosphate"}
{"X":55808,"RHEA_ID":57802,"compounds":"4-methyl-3-nitrocatechol + H(+) + NAD(+) + nitrite => 2,3-dinitrotoluene + NADH + O2"}
{"X":55809,"RHEA_ID":54459,"compounds":"1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate"}
{"X":55810,"RHEA_ID":61382,"compounds":"2,4-dinitrophenyl-S-glutathione(out) + ADP + H(+) + phosphate => 2,4-dinitrophenyl-S-glutathione(in) + ATP + H2O"}
{"X":55811,"RHEA_ID":57805,"compounds":"1-chloro-3-nitrobenzene + NADH + O2 => 4-chlorocatechol + NAD(+) + nitrite"}
{"X":55812,"RHEA_ID":62764,"compounds":"4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 = 4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":55813,"RHEA_ID":54463,"compounds":"1-octadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate"}
{"X":55814,"RHEA_ID":57808,"DIRECTION":"UN","MASTER_ID":57808,"metacyc":"RXN-16794","compounds":"1-chloro-3-nitrobenzene + NADH + O2 = 3-chlorocatechol + NAD(+) + nitrite"}
{"X":55815,"RHEA_ID":57809,"compounds":"1-chloro-3-nitrobenzene + NADH + O2 => 3-chlorocatechol + NAD(+) + nitrite"}
{"X":55816,"RHEA_ID":54466,"compounds":"1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexanoate => 1-octadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":55817,"RHEA_ID":54467,"compounds":"1-octadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexanoate"}
{"X":55818,"RHEA_ID":57812,"compounds":"1-chloro-2-nitrobenzene + NADH + O2 = 3-chlorocatechol + NAD(+) + nitrite"}
{"X":55819,"RHEA_ID":60109,"DIRECTION":"LR","MASTER_ID":60108,"metacyc":"RXN-19898","compounds":"(R)-3-(4-hydroxyphenyl)lactoyl-CoA => (E)-4-coumaroyl-CoA + H2O"}
{"X":55820,"RHEA_ID":57814,"compounds":"3-chlorocatechol + NAD(+) + nitrite => 1-chloro-2-nitrobenzene + NADH + O2"}
{"X":55821,"RHEA_ID":54471,"compounds":"1-octadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + octanoate"}
{"X":55822,"RHEA_ID":57816,"compounds":"dGMP + H2O = 2-deoxy-D-ribose 5-phosphate + guanine"}
{"X":55823,"RHEA_ID":55576,"compounds":"4-hydroxy-N-methyltryptamine 4-phosphate + S-adenosyl-L-methionine = H(+) + psilocybin + S-adenosyl-L-homocysteine"}
{"X":55824,"RHEA_ID":57817,"compounds":"dGMP + H2O => 2-deoxy-D-ribose 5-phosphate + guanine"}
{"X":55825,"RHEA_ID":55578,"compounds":"H(+) + psilocybin + S-adenosyl-L-homocysteine => 4-hydroxy-N-methyltryptamine 4-phosphate + S-adenosyl-L-methionine"}
{"X":55826,"RHEA_ID":56708,"DIRECTION":"UN","MASTER_ID":56708,"ec":"1.14.14.171","compounds":"beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":55827,"RHEA_ID":62782,"compounds":"4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O => 4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2"}
{"X":55828,"RHEA_ID":57822,"compounds":"[phosphate](n+1) + AMP => [phosphate](n) + ADP"}
{"X":55829,"RHEA_ID":56711,"compounds":"beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> 16alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":55830,"RHEA_ID":56712,"DIRECTION":"UN","MASTER_ID":56712,"ec":"2.5.1.145","compounds":"1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate"}
{"X":55831,"RHEA_ID":55584,"DIRECTION":"UN","MASTER_ID":55584,"ec":"2.1.1.348","compounds":"adenosine in mRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine in mRNA + S-adenosyl-L-homocysteine"}
{"X":55832,"RHEA_ID":54482,"compounds":"1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate => 1-octadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":55833,"RHEA_ID":60123,"compounds":"(2E,6E)-farnesyl diphosphate + S-adenosyl-L-methionine <=> H(+) + pre-sodorifen diphosphate + S-adenosyl-L-homocysteine"}
{"X":55834,"RHEA_ID":61406,"compounds":"ADP + H(+) + N-(3-O-phospho-D-ribulosyl)-cadaverine => ATP + N-(D-ribulosyl)-cadaverine"}
{"X":55835,"RHEA_ID":59336,"compounds":"1-hydroxy-all-trans-1,2-dihydro-neurosporene + A = AH2 + demethylspheroidene"}
{"X":55836,"RHEA_ID":57830,"compounds":"2-deoxy-D-ribose 5-phosphate + hypoxanthine => dIMP + H2O"}
{"X":55837,"RHEA_ID":58942,"compounds":"all-trans-lycopaoctaene + diphosphate + NAD(+) => (1R,2R,3R)-prephytoene diphosphate + H(+) + NADH"}
{"X":55838,"RHEA_ID":57083,"compounds":"1-methylsulfanyl-D-xylulose 5-phosphate + glutathione <=> 1-deoxy-D-xylulose 5-phosphate + S-(methylsulfanyl)glutathione"}
{"X":55839,"RHEA_ID":54857,"compounds":"H(+) + NADPH + O2 + octan-3-one => ethyl hexanoate + H2O + NADP(+)"}
{"X":55840,"RHEA_ID":57834,"compounds":"glutarate + 2 H(+) + NADPH => 5-oxopentanoate + H2O + NADP(+)"}
{"X":55841,"RHEA_ID":56723,"compounds":"2 [Fe(III)cytochrome c] + L-cysteinyl-[SoxY protein] + thiosulfate <=> 2 [Fe(II)cytochrome c] + 2 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]"}
{"X":55842,"RHEA_ID":60131,"compounds":"17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O <=> 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + H(+) + phosphate"}
{"X":55843,"RHEA_ID":60132,"compounds":"a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2 = a (8S,9S)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate"}
{"X":55844,"RHEA_ID":57838,"compounds":"3-aminopropanal + H2O2 + spermidine => H2O + O2 + thermospermine"}
{"X":55845,"RHEA_ID":56727,"compounds":"AH2 + all-trans-beta-carotene + O2 <=> 4-hydroxy-all-trans-beta-carotene + A + H2O"}
{"X":55846,"RHEA_ID":58951,"compounds":"4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine <=> 4-O-([3-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP"}
{"X":55847,"RHEA_ID":55601,"compounds":"an inositol-1-phosphoceramide + GDP-alpha-D-mannose => a mannosylinositol-1-phosphoceramide + GDP + H(+)"}
{"X":55848,"RHEA_ID":60139,"compounds":"a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2 <=> a (8S,9R)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate"}
{"X":55849,"RHEA_ID":55603,"compounds":"an inositol-1-phosphoceramide + GDP-alpha-D-mannose <=> a mannosylinositol-1-phosphoceramide + GDP + H(+)"}
{"X":55850,"RHEA_ID":58956,"compounds":"a ribonucleotide in RNA + S-adenosyl-L-methionine = a 2'-O-methylribonucleotide in RNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":55851,"RHEA_ID":54870,"compounds":"butanoyl-[ACP] + NAD(+) => (2E)-butenoyl-[ACP] + H(+) + NADH"}
{"X":55852,"RHEA_ID":60143,"compounds":"dodecanoyl-CoA + H(+) + malonyl-CoA <=> 3-oxotetradecanoyl-CoA + CO2 + CoA"}
{"X":55853,"RHEA_ID":61426,"compounds":"cis-cis-nepetalactone + H(+) + NADH => cis-cis-nepetalactol + NAD(+)"}
{"X":55854,"RHEA_ID":60145,"compounds":"ATP + L-glutamate + L-glutamyl-[protein] => ADP + H(+) + L-gamma-glutamyl-L-glutamyl-[protein] + phosphate"}
{"X":55855,"RHEA_ID":54506,"compounds":"beta-hexaprene + diphosphate => all-trans-hexaprenyl diphosphate"}
{"X":55856,"RHEA_ID":57850,"compounds":"CO2 + fraxetin + succinate => 2-oxoglutarate + O2 + scopoletin"}
{"X":55857,"RHEA_ID":61430,"compounds":"cis-trans-nepetalactone + H(+) + NADH => cis-trans-nepetalactol + NAD(+)"}
{"X":55858,"RHEA_ID":58215,"compounds":"ajmalicine + O2 + reduced [NADPH--hemoprotein reductase] <=> dihydroserpentine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":55859,"RHEA_ID":54510,"compounds":"beta-heptaprene + diphosphate => all-trans-heptaprenyl diphosphate"}
{"X":55860,"RHEA_ID":54511,"compounds":"all-trans-heptaprenyl diphosphate <=> beta-heptaprene + diphosphate"}
{"X":55861,"RHEA_ID":56744,"compounds":"2-oxoglutarate + L-arginyl-[protein] + O2 = (3R)-3-hydroxy-L-arginyl-[protein] + CO2 + succinate"}
{"X":55862,"RHEA_ID":60153,"compounds":"H2O + L-gamma-glutamyl-L-glutamyl-[protein] => L-glutamate + L-glutamyl-[protein]"}
{"X":55863,"RHEA_ID":55621,"compounds":"a carotenoid psi-end group => a carotenoid beta-end derivative"}
{"X":55864,"RHEA_ID":58220,"compounds":"L-lysyl-[protein] + NAD(+) = H(+) + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide"}
{"X":55865,"RHEA_ID":57859,"compounds":"(E)-feruloyl-CoA + 2-oxoglutarate + O2 <=> (E)-6-hydroxyferuloyl-CoA + CO2 + succinate"}
{"X":55866,"RHEA_ID":58972,"compounds":"H2O + O2 + vanillin = 4-hydroxy-3-methoxybenzoate + H(+) + H2O2"}
{"X":55867,"RHEA_ID":57861,"DIRECTION":"LR","MASTER_ID":57860,"metacyc":"RXN-12350","compounds":"(E)-6-hydroxyferuloyl-CoA => CoA + scopoletin"}
{"X":55868,"RHEA_ID":61441,"compounds":"acetyl-CoA + S-(2-succino)-L-cysteine => CoA + H(+) + N-acetyl-S-(2-succino)-L-cysteine"}
{"X":55869,"RHEA_ID":58975,"compounds":"H2O + O2 + vanillin <=> 4-hydroxy-3-methoxybenzoate + H(+) + H2O2"}
{"X":55870,"RHEA_ID":55636,"compounds":"ATP + C-terminal L-cysteinyl-[HypE protein] + carbamoyl phosphate + H2O = AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + diphosphate + H(+) + phosphate"}
{"X":55871,"RHEA_ID":54522,"compounds":"cycloaraneosene + diphosphate => all-trans-geranylgeranyl diphosphate"}
{"X":55872,"RHEA_ID":61445,"compounds":"a tetracycline + H(+) + NADPH + O2 => an 11a-hydroxytetracycline + H2O + NADP(+)"}
{"X":55873,"RHEA_ID":57867,"compounds":"indole-3-carbonyl nitrile + O2 + reduced [NADPH--hemoprotein reductase] <=> 4-hydroxy-indole-3-carbonyl nitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":55874,"RHEA_ID":60164,"compounds":"a guanosine in RNA + S-adenosyl-L-methionine = an N(7)-methylguanosine in RNA + S-adenosyl-L-homocysteine"}
{"X":55875,"RHEA_ID":58981,"compounds":"citral + H2O + O2 => 3,7-dimethylocta-2,6-dienoate + H(+) + H2O2"}
{"X":55876,"RHEA_ID":54527,"compounds":"acetoacetate + H(+) + methylglyoxal <=> 3-hydroxyhexane-2,5-dione + CO2"}
{"X":55877,"RHEA_ID":57871,"compounds":"(E)-4-coumaroyl-CoA + 2-oxoglutarate + O2 <=> (E)-2,4-dihydroxycinnamoyl-CoA + CO2 + succinate"}
{"X":55878,"RHEA_ID":54529,"compounds":"aldehydo-D-ribose 5-phosphate => D-ribose 5-phosphate"}
{"X":55879,"RHEA_ID":54530,"compounds":"D-ribose 5-phosphate => aldehydo-D-ribose 5-phosphate"}
{"X":55880,"RHEA_ID":54531,"compounds":"aldehydo-D-ribose 5-phosphate <=> D-ribose 5-phosphate"}
{"X":55881,"RHEA_ID":57875,"compounds":"(E)-2,4-dihydroxycinnamoyl-CoA <=> CoA + umbelliferone"}
{"X":55882,"RHEA_ID":60644,"compounds":"3'-phosphoadenylyl sulfate + 3alpha-hydroxy-5alpha-androstan-17-one = 3alpha-sulfooxy-5alpha-androstan-17-one + adenosine 3',5'-bisphosphate + H(+)"}
{"X":55883,"RHEA_ID":54902,"compounds":"hexadecanoyl-[ACP] + NAD(+) => (2E)-hexadecenoyl-[ACP] + H(+) + NADH"}
{"X":55884,"RHEA_ID":58241,"compounds":"H2O + S-(ADP-D-ribosyl)-L-cysteinyl-[protein] => ADP-D-ribose + L-cysteinyl-[protein]"}
{"X":55885,"RHEA_ID":61458,"compounds":"(1S,10S,10aS)-3-(CONH2)-9-Cl-1-(Me2N)-3,3a,4,10-(HO)4-10-Me-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracen-6-olate + CO + H2O + NADP(+) => 7-chlorotetracycline + H(+) + NADPH + O2"}
{"X":55886,"RHEA_ID":61459,"compounds":"7-chlorotetracycline + H(+) + NADPH + O2 <=> (1S,10S,10aS)-3-(CONH2)-9-Cl-1-(Me2N)-3,3a,4,10-(HO)4-10-Me-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracen-6-olate + CO + H2O + NADP(+)"}
{"X":55887,"RHEA_ID":54906,"compounds":"(9Z)-hexadecenoyl-[ACP] + NAD(+) => (2E,9Z)-hexadecadienoyl-[ACP] + H(+) + NADH"}
{"X":55888,"RHEA_ID":54539,"compounds":"a very long-chain fatty acid + ATP + CoA <=> a very long-chain fatty acyl-CoA + AMP + diphosphate"}
{"X":55889,"RHEA_ID":56772,"DIRECTION":"UN","MASTER_ID":56772,"ec":"1.14.99.64","compounds":"2 AH2 + all-trans-adonixanthin + 2 O2 = 2 A + all-trans-(3S,3'S)-astaxanthin + 3 H2O"}
{"X":55890,"RHEA_ID":58996,"compounds":"H2O + indole-3-carbaldehyde + O2 = H(+) + H2O2 + indole-3-carboxylate"}
{"X":55891,"RHEA_ID":54542,"compounds":"beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-threonyl-[protein] => H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein]"}
{"X":55892,"RHEA_ID":61465,"compounds":"a cytidine in mRNA + S-adenosyl-L-methionine => a 5-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":55893,"RHEA_ID":57887,"compounds":"diphosphate + H2O + Na(+)(in) <=> H(+) + Na(+)(out) + 2 phosphate"}
{"X":55894,"RHEA_ID":60197,"DIRECTION":"LR","MASTER_ID":60196,"metacyc":"RXN-20635","compounds":"2-oxoglutarate + N(6)-methyl-L-lysyl(9)-[histone H3] + O2 => CO2 + formaldehyde + L-lysyl(9)-[histone H3] + succinate"}
{"X":55895,"RHEA_ID":54546,"compounds":"1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine + hexanoyl-sn-glycero-3-phosphoethanolamine => 1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine + 2-heptanoyl-sn-glycero-3-phosphocholine"}
{"X":55896,"RHEA_ID":55662,"compounds":"2 A + echinenone + 3 H2O => 2 AH2 + all-trans-beta-carotene + 2 O2"}
{"X":55897,"RHEA_ID":57891,"compounds":"a quinone + 5 H(+)(in) + NADH <=> a quinol + 4 H(+)(out) + NAD(+)"}
{"X":55898,"RHEA_ID":61471,"compounds":"a cytidine in tRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":55899,"RHEA_ID":54550,"compounds":"D-xylulose 5-phosphate + phosphate => D-xylulose 1,5-bisphosphate + H2O"}
{"X":55900,"RHEA_ID":54551,"compounds":"D-xylulose 1,5-bisphosphate + H2O <=> D-xylulose 5-phosphate + phosphate"}
{"X":55901,"RHEA_ID":60204,"compounds":"2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + O2 = CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + succinate"}
{"X":55902,"RHEA_ID":57896,"compounds":"2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + O2 = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + CO2 + formaldehyde + succinate"}
{"X":55903,"RHEA_ID":57897,"compounds":"2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + O2 => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + CO2 + formaldehyde + succinate"}
{"X":55904,"RHEA_ID":54555,"compounds":"1-O-hexadecyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate"}
{"X":55905,"RHEA_ID":57899,"compounds":"2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + O2 <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + CO2 + formaldehyde + succinate"}
{"X":55906,"RHEA_ID":59012,"DIRECTION":"UN","MASTER_ID":59012,"ec":"2.1.1.41","compounds":"cycloartenol + S-adenosyl-L-methionine = 24-methylenecycloartanol + H(+) + S-adenosyl-L-homocysteine"}
{"X":55907,"RHEA_ID":54926,"compounds":"3-oxo-(9Z)-hexadecenoyl-[ACP] + CO2 + holo-[ACP] => (7Z)-tetradecenoyl-[ACP] + H(+) + malonyl-[ACP]"}
{"X":55908,"RHEA_ID":54559,"compounds":"5'-end ribonucleotide-tRNA(His) + ATP + H(+) <=> an adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + diphosphate"}
{"X":55909,"RHEA_ID":57903,"compounds":"2-oxoglutarate + N(6)-methyladenosine in U6 snRNA + O2 <=> adenosine in U6 snRNA + CO2 + formaldehyde + succinate"}
{"X":55910,"RHEA_ID":61483,"compounds":"a sphingoid base + a very long-chain fatty acyl-CoA <=> an N-(very-long-chain fatty acyl)-sphingoid base + CoA + H(+)"}
{"X":55911,"RHEA_ID":57905,"compounds":"2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in U6 snRNA + O2 => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in U6 snRNA + CO2 + formaldehyde + succinate"}
{"X":55912,"RHEA_ID":54563,"compounds":"an adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + GTP <=> a 5'-triphospho-guanosine-ribonucleotide-tRNA(His) + AMP + H(+)"}
{"X":55913,"RHEA_ID":57907,"compounds":"2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in U6 snRNA + O2 <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in U6 snRNA + CO2 + formaldehyde + succinate"}
{"X":55914,"RHEA_ID":61487,"compounds":"a cytidine in rRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":55915,"RHEA_ID":57909,"DIRECTION":"LR","MASTER_ID":57908,"metacyc":"RXN-20082","compounds":"ATP + L-glutamyl-tRNA(Gln) => 5-phosphooxy-L-glutamyl-tRNA(Gln) + ADP"}
{"X":55916,"RHEA_ID":54567,"compounds":"5'-end ribonucleotide-tRNA(His) + ATP + GTP + H2O <=> a 5'-phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)"}
{"X":55917,"RHEA_ID":57911,"compounds":"ATP + L-glutamyl-tRNA(Gln) <=> 5-phosphooxy-L-glutamyl-tRNA(Gln) + ADP"}
{"X":55918,"RHEA_ID":61491,"compounds":"cytidine(50) in tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(50) in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":55919,"RHEA_ID":60222,"compounds":"CO2 + formaldehyde + L-lysyl(4)-[histone H3] + succinate => 2-oxoglutarate + N(6)-methyl-L-lysyl(4)-[histone H3] + O2"}
{"X":55920,"RHEA_ID":54571,"DIRECTION":"BI","MASTER_ID":54568,"metacyc":"RXN-16477","compounds":"a uridine in rRNA <=> a pseudouridine in rRNA"}
{"X":55921,"RHEA_ID":57915,"compounds":"5-phosphooxy-L-glutamyl-tRNA(Gln) + NH4(+) <=> H(+) + L-glutaminyl-tRNA(Gln) + phosphate"}
{"X":55922,"RHEA_ID":61495,"compounds":"a sphingoid base + ultra-long-chain fatty acyl-CoA <=> an N-(ultra-long-chain-acyl)-sphingoid base + CoA + H(+)"}
{"X":55923,"RHEA_ID":54574,"compounds":"a pseudouridine in tRNA => a uridine in tRNA"}
{"X":55924,"RHEA_ID":57919,"compounds":"ATP + L-aspartyl-tRNA(Asn) <=> 4-phosphooxy-L-aspartyl-tRNA(Asn) + ADP + H(+)"}
{"X":55925,"RHEA_ID":59837,"compounds":"H2O + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein] => 3-deoxyglucosone + L-lysyl-[protein] + phosphate"}
{"X":55926,"RHEA_ID":56084,"compounds":"[Rab1 protein]-O-phosphocholine-L-serine + H2O = [Rab1 protein]-L-serine + H(+) + phosphocholine"}
{"X":55927,"RHEA_ID":54579,"compounds":"2-oxoglutarate + an N(1)-methyladenosine in tRNA + O2 <=> an adenosine in tRNA + CO2 + formaldehyde + succinate"}
{"X":55928,"RHEA_ID":61501,"DIRECTION":"LR","MASTER_ID":61500,"metacyc":"RXN-7815","compounds":"delphinidin + UDP-alpha-D-glucose => delphinidin 3-O-beta-D-glucoside + UDP"}
{"X":55929,"RHEA_ID":59439,"DIRECTION":"BI","MASTER_ID":59436,"metacyc":"RXN-20195","compounds":"4-amino-L-phenylalanine + ATP + holo-[peptidyl-carrier protein] <=> 4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AMP + diphosphate"}
{"X":55930,"RHEA_ID":54950,"compounds":"(2E,5Z)-dodecadienoyl-[ACP] + H2O => (3R)-hydroxy-(5Z)-dodecenoyl-[ACP]"}
{"X":55931,"RHEA_ID":54583,"compounds":"5'-dephospho-(RNA) + ATP <=> 5'-end-(RNA) + ADP + H(+)"}
{"X":55932,"RHEA_ID":61994,"compounds":"H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine"}
{"X":55933,"RHEA_ID":59040,"compounds":"4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 = 4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":55934,"RHEA_ID":60238,"compounds":"2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + 2 succinate => 2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 2 O2"}
{"X":55935,"RHEA_ID":54587,"compounds":"a guanosine in 18S rRNA + S-adenosyl-L-methionine <=> an N(7)-methylguanosine in 18S rRNA + S-adenosyl-L-homocysteine"}
{"X":55936,"RHEA_ID":57931,"compounds":"ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + H2O + L-glutamine <=> ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + H(+) + L-glutamate + phosphate"}
{"X":55937,"RHEA_ID":55716,"compounds":"(S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(2'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O = (9Z)-octadecenoate + (S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+)"}
{"X":55938,"RHEA_ID":59044,"DIRECTION":"UN","MASTER_ID":59044,"ec":"2.4.1.363","compounds":"dammarenediol-II + UDP-alpha-D-glucose = (20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + H(+) + UDP"}
{"X":55939,"RHEA_ID":54591,"compounds":"S-adenosyl-L-methionine + uridine in 25S rRNA <=> H(+) + N(3)-methyluridine in 25S rRNA + S-adenosyl-L-homocysteine"}
{"X":55940,"RHEA_ID":59047,"compounds":"dammarenediol-II + UDP-alpha-D-glucose <=> (20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + H(+) + UDP"}
{"X":55941,"RHEA_ID":59048,"DIRECTION":"UN","MASTER_ID":59048,"ec":"4.1.1.116","compounds":"D-ornithine + H(+) = CO2 + putrescine"}
{"X":55942,"RHEA_ID":54962,"compounds":"AMP + dinor-OPDA-CoA + diphosphate => ATP + CoA + dinor-OPDA"}
{"X":55943,"RHEA_ID":61515,"compounds":"malvidin + UDP-alpha-D-glucose <=> malvidin 3-O-beta-D-glucoside + UDP"}
{"X":55944,"RHEA_ID":54596,"compounds":"2-oxoglutarate + hexadecanoyl-CoA + O2 = 2-hydroxyhexadecanoyl-CoA + CO2 + succinate"}
{"X":55945,"RHEA_ID":61523,"compounds":"AH2 + dopamine <=> 3-tyramine + A + H2O"}
{"X":55946,"RHEA_ID":60250,"compounds":"AH2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3] => A + H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3]"}
{"X":55947,"RHEA_ID":54599,"compounds":"2-oxoglutarate + hexadecanoyl-CoA + O2 <=> 2-hydroxyhexadecanoyl-CoA + CO2 + succinate"}
{"X":55948,"RHEA_ID":60252,"compounds":"(S)-methylmalonyl-CoA + NADP(+) = acryloyl-CoA + CO2 + NADPH"}
{"X":55949,"RHEA_ID":61527,"compounds":"(8Z,11Z,14Z)-eicosatrienoate + O2 <=> (15S)-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate"}
{"X":55950,"RHEA_ID":59057,"compounds":"2 methanethiol + NAD(+) => dimethyl disulfide + H(+) + NADH"}
{"X":55951,"RHEA_ID":60255,"compounds":"(S)-methylmalonyl-CoA + NADP(+) <=> acryloyl-CoA + CO2 + NADPH"}
{"X":55952,"RHEA_ID":58313,"compounds":"25-substituted-cholesteryl beta-D-glucoside + H2O => 25-substituted-cholesterol + D-glucose"}
{"X":55953,"RHEA_ID":54605,"compounds":"2-oxoglutarate + decanoyl-CoA + O2 => 2-hydroxydecanoyl-CoA + CO2 + succinate"}
{"X":55954,"RHEA_ID":57949,"DIRECTION":"LR","MASTER_ID":57948,"metacyc":"O-CRESOL-METHYLCATECHOL-RXN","compounds":"2-hydroxytoluene + H(+) + NADH + O2 => 3-methylcatechol + H2O + NAD(+)"}
{"X":55955,"RHEA_ID":54975,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-[ACP] <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphate + holo-[ACP]"}
{"X":55956,"RHEA_ID":58317,"compounds":"beta-D-glucosyl-N-hexadecanoylsphing-4E-enine + cholesterol => cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine"}
{"X":55957,"RHEA_ID":57952,"DIRECTION":"UN","MASTER_ID":57952,"ec":"1.14.13.244","compounds":"H(+) + NADH + O2 + phenol = catechol + H2O + NAD(+)"}
{"X":55958,"RHEA_ID":61567,"compounds":"a tetracycline + H(+) + NADPH + O2 <=> a (1S,10aS)-3-(CONH2)-1-(Me2N)-3,3a,4,6-(HO)4-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracene + CO + H2O + NADP(+)"}
{"X":55959,"RHEA_ID":54979,"compounds":"(3S)-hydroxytetradecanoyl-CoA + H2O <=> (3S)-hydroxytetradecanoate + CoA + H(+)"}
{"X":55960,"RHEA_ID":54980,"DIRECTION":"UN","MASTER_ID":54980,"ec":"2.4.1.371","compounds":"alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-di-trans,octa-cis-undecaprenol + 2 GDP-alpha-D-mannose = [alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n+1)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenol + 2 GDP + 2 H(+)"}
{"X":55961,"RHEA_ID":54613,"compounds":"2-oxoglutarate + 3-methylbutanoyl-CoA + O2 => 2-hydroxy-3-methylbutanoyl-CoA + CO2 + succinate"}
{"X":55962,"RHEA_ID":61572,"compounds":"(11Z,14Z)-eicosadienoate + O2 = (15S)-hydroperoxy-(11Z,13E)-eicosadienoate"}
{"X":55963,"RHEA_ID":61571,"compounds":"an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O <=> an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + D-galactosamine"}
{"X":55964,"RHEA_ID":57210,"compounds":"S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein] => glyoxal + L-cysteinyl-[protein]"}
{"X":55965,"RHEA_ID":61575,"compounds":"(11Z,14Z)-eicosadienoate + O2 <=> (15S)-hydroperoxy-(11Z,13E)-eicosadienoate"}
{"X":55966,"RHEA_ID":58328,"compounds":"(Z)-non-6-en-1-ol + NADP(+) = (Z)-non-6-enal + H(+) + NADPH"}
{"X":55967,"RHEA_ID":54987,"compounds":"a ubiquinol <=> a ubiquinone + 2 e(-) + 2 H(+)"}
{"X":55968,"RHEA_ID":58330,"compounds":"(Z)-non-6-enal + H(+) + NADPH => (Z)-non-6-en-1-ol + NADP(+)"}
{"X":55969,"RHEA_ID":60273,"DIRECTION":"LR","MASTER_ID":60272,"metacyc":"RXN-20610","compounds":"N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":55970,"RHEA_ID":54990,"compounds":"2 H2O(in) => 4 e(-) + 4 H(+)(in) + O2(in)"}
{"X":55971,"RHEA_ID":54991,"compounds":"4 e(-) + 4 H(+)(in) + O2(in) <=> 2 H2O(in)"}
{"X":55972,"RHEA_ID":54624,"compounds":"2-oxoglutarate + O2 + octadecanoyl-CoA = 2-hydroxyoctadecanoyl-CoA + CO2 + succinate"}
{"X":55973,"RHEA_ID":61583,"compounds":"(3S)-3-hydroxycyclohexane-1-carbonyl-CoA + NADP(+) <=> (5S)-5-hydroxycyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH"}
{"X":55974,"RHEA_ID":56857,"compounds":"A + an aldehyde + H2O => a carboxylate + AH2 + H(+)"}
{"X":55975,"RHEA_ID":54627,"compounds":"2-oxoglutarate + O2 + octadecanoyl-CoA <=> 2-hydroxyoctadecanoyl-CoA + CO2 + succinate"}
{"X":55976,"RHEA_ID":54628,"compounds":"2-oxoglutarate + dodecanoyl-CoA + O2 = 2-hydroxydodecanoyl-CoA + CO2 + succinate"}
{"X":55977,"RHEA_ID":61587,"compounds":"cytidine(72) in tRNA(Cys) + S-adenosyl-L-methionine <=> 5-methylcytidine(72) in tRNA(Cys) + H(+) + S-adenosyl-L-homocysteine"}
{"X":55978,"RHEA_ID":60282,"compounds":"H(+) + N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine => L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine"}
{"X":55979,"RHEA_ID":56862,"compounds":"a 2-oxo-3-(phosphooxy)propyl medium-chain 3-oxoalkanoate + holo-[ACP] => a medium-chain 3-oxoacyl-[ACP] + dihydroxyacetone phosphate"}
{"X":55980,"RHEA_ID":56863,"compounds":"a medium-chain 3-oxoacyl-[ACP] + dihydroxyacetone phosphate <=> a 2-oxo-3-(phosphooxy)propyl medium-chain 3-oxoalkanoate + holo-[ACP]"}
{"X":55981,"RHEA_ID":54633,"compounds":"2-oxoglutarate + O2 + tetradecanoyl-CoA => 2-hydroxytetradecanoyl-CoA + CO2 + succinate"}
{"X":55982,"RHEA_ID":60286,"compounds":"H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine"}
{"X":55983,"RHEA_ID":54635,"compounds":"2-oxoglutarate + O2 + tetradecanoyl-CoA <=> 2-hydroxytetradecanoyl-CoA + CO2 + succinate"}
{"X":55984,"RHEA_ID":60288,"compounds":"N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":55985,"RHEA_ID":54637,"DIRECTION":"LR","MASTER_ID":54636,"metacyc":"RXN-18983","compounds":"(13E)-labda-7,13-dien-15-yl diphosphate => diphosphate + labda-7,13(16),14-triene"}
{"X":55986,"RHEA_ID":60290,"compounds":"H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine"}
{"X":55987,"RHEA_ID":58348,"compounds":"2 2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 O2 = 2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate"}
{"X":55988,"RHEA_ID":54640,"DIRECTION":"UN","MASTER_ID":54640,"ec":"4.2.3.193","compounds":"(+)-copalyl diphosphate = (12E)-labda-8(17),12,14-triene + diphosphate"}
{"X":55989,"RHEA_ID":54641,"DIRECTION":"LR","MASTER_ID":54640,"metacyc":"RXN-18984","compounds":"(+)-copalyl diphosphate => (12E)-labda-8(17),12,14-triene + diphosphate"}
{"X":55990,"RHEA_ID":61604,"compounds":"[DsbA protein]-dithiol + [DsbB protein]-disulfide = [DsbA protein]-disulfide + [DsbB protein]-dithiol"}
{"X":55991,"RHEA_ID":56874,"compounds":"(S)-1-phenylethylamine + acetate => (S)-N-acetyl-1-phenylethylamine + H2O"}
{"X":55992,"RHEA_ID":54644,"DIRECTION":"UN","MASTER_ID":54644,"ec":"4.2.1.172","compounds":"trans-4-hydroxy-L-proline = (S)-1-pyrroline-5-carboxylate + H(+) + H2O"}
{"X":55993,"RHEA_ID":54645,"DIRECTION":"LR","MASTER_ID":54644,"metacyc":"RXN-18502","compounds":"trans-4-hydroxy-L-proline => (S)-1-pyrroline-5-carboxylate + H(+) + H2O"}
{"X":55994,"RHEA_ID":61608,"compounds":"[DsbB protein]-dithiol + a quinone = [DsbB protein]-disulfide + a quinol"}
{"X":55995,"RHEA_ID":59102,"compounds":"H(+) + triglucosyl-enterobactin + UDP => diglucosyl-enterobactin + UDP-alpha-D-glucose"}
{"X":55996,"RHEA_ID":55016,"compounds":"H(+) + menthone + NADPH + O2 = 7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)"}
{"X":55997,"RHEA_ID":57991,"compounds":"(20S)-ginsenoside Rh2 + UDP-alpha-D-glucose <=> (20S)-ginsenoside F2 + H(+) + UDP"}
{"X":55998,"RHEA_ID":61610,"compounds":"[DsbB protein]-disulfide + a quinol => [DsbB protein]-dithiol + a quinone"}
{"X":55999,"RHEA_ID":56882,"compounds":"a 3-oxo-Delta(5)-steroid + H(+) + NADPH => a 3beta-hydroxy-Delta(5)-steroid + NADP(+)"}
{"X":56000,"RHEA_ID":59107,"compounds":"chenodeoxycholate + dolichyl beta-D-glucosyl phosphate <=> beta-D-glucosyl-(1->3)-O-chenodeoxycholate + dolichyl phosphate + H(+)"}
{"X":56001,"RHEA_ID":59108,"compounds":"chenodeoxycholate + octyl beta-D-glucose = beta-D-glucosyl-(1->3)-O-chenodeoxycholate + octan-1-ol"}
{"X":56002,"RHEA_ID":56160,"DIRECTION":"UN","MASTER_ID":56160,"ec":"2.4.1.356","compounds":"an archaeal dolichyl alpha-D-glucosyl phosphate + UDP-alpha-D-glucuronate = an archaeal dolichyl beta-D-glucuronosyl-(1->4)-alpha-D-glucosyl phosphate + H(+) + UDP"}
{"X":56003,"RHEA_ID":56886,"compounds":"2'-O-methyladenosine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine => adenosine(32) in tRNA + S-adenosyl-L-methionine"}
{"X":56004,"RHEA_ID":60307,"compounds":"N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":56005,"RHEA_ID":58000,"DIRECTION":"UN","MASTER_ID":58000,"ec":"2.4.1.365","compounds":"(20S)-ginsenoside Rh2 + UDP-alpha-D-glucose = (20S)-ginsenoside Rg3 + H(+) + UDP"}
{"X":56006,"RHEA_ID":60310,"compounds":"2 H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-homocysteine => L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-methionine"}
{"X":56007,"RHEA_ID":56890,"compounds":"UDP-4-dehydro-beta-L-rhamnose => UDP-4-dehydro-6-deoxy-alpha-D-glucose"}
{"X":56008,"RHEA_ID":54660,"DIRECTION":"UN","MASTER_ID":54660,"ec":"4.1.2.47","compounds":"an aromatic (S)-hydroxynitrile = an aromatic aldehyde + hydrogen cyanide"}
{"X":56009,"RHEA_ID":59116,"compounds":"[protein]-dithiol + O2 = [protein]-disulfide + H2O2"}
{"X":56010,"RHEA_ID":61626,"compounds":"5-aminopentanal + L-glutamate => 2-oxoglutarate + cadaverine"}
{"X":56011,"RHEA_ID":60315,"compounds":"L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":56012,"RHEA_ID":59120,"DIRECTION":"UN","MASTER_ID":59120,"ec":"4.1.1.117","compounds":"2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + H(+) = 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + CO2"}
{"X":56013,"RHEA_ID":56898,"compounds":"an acyl-AMP + diphosphate => a carboxylate + ATP + H(+)"}
{"X":56014,"RHEA_ID":54668,"DIRECTION":"UN","MASTER_ID":54668,"ec":"5.4.99.66","compounds":"pre-alpha-onocerin = alpha-onocerin"}
{"X":56015,"RHEA_ID":54669,"DIRECTION":"LR","MASTER_ID":54668,"metacyc":"RXN-19014","compounds":"pre-alpha-onocerin => alpha-onocerin"}
{"X":56016,"RHEA_ID":56901,"compounds":"globoside GalGb4Cer + UDP-N-acetyl-alpha-D-glucosamine => globoside GlcNAc-(beta1->6)-GalGb4Cer + H(+) + UDP"}
{"X":56017,"RHEA_ID":56902,"compounds":"globoside GlcNAc-(beta1->6)-GalGb4Cer + H(+) + UDP => globoside GalGb4Cer + UDP-N-acetyl-alpha-D-glucosamine"}
{"X":56018,"RHEA_ID":58014,"compounds":"2 5'-hydroxy-diadenylate 2',3'-cylic phosphate => cyclic tetraadenylate"}
{"X":56019,"RHEA_ID":60325,"DIRECTION":"LR","MASTER_ID":60324,"metacyc":"RXN-20619","compounds":"L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine"}
{"X":56020,"RHEA_ID":59129,"DIRECTION":"LR","MASTER_ID":59128,"metacyc":"RXN-19822","compounds":"(S)-2,3-diaminopropanoate + 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + ATP => 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + AMP + diphosphate"}
{"X":56021,"RHEA_ID":60327,"compounds":"L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine"}
{"X":56022,"RHEA_ID":58018,"compounds":"6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":56023,"RHEA_ID":54677,"DIRECTION":"LR","MASTER_ID":54676,"metacyc":"RXN-18977","compounds":"all-trans-geranylgeranyl diphosphate => (+)-kolavenyl diphosphate"}
{"X":56024,"RHEA_ID":58020,"DIRECTION":"UN","MASTER_ID":58020,"metacyc":"RXN-20053","compounds":"6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) = eupatolide + H2O"}
{"X":56025,"RHEA_ID":60331,"compounds":"L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine"}
{"X":56026,"RHEA_ID":58022,"compounds":"eupatolide + H2O => 6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+)"}
{"X":56027,"RHEA_ID":54685,"DIRECTION":"LR","MASTER_ID":54684,"metacyc":"RXN-18893","compounds":"all-trans-geranylgeranyl diphosphate => (-)-kolavenyl diphosphate"}
{"X":56028,"RHEA_ID":59137,"DIRECTION":"LR","MASTER_ID":59136,"metacyc":"RXN-19522","compounds":"ATP + citrate + D-ornithine => AMP + diphosphate + H(+) + N(5)-[(S)-citryl]-D-ornithine"}
{"X":56029,"RHEA_ID":61661,"DIRECTION":"LR","MASTER_ID":61660,"metacyc":"RXN-12307","compounds":"ATP + geraniol => (2E)-geranyl phosphate + ADP + H(+)"}
{"X":56030,"RHEA_ID":58026,"compounds":"H(+) + oleanolate 3-O-beta-D-glucoside + UDP => oleanolate + UDP-alpha-D-glucose"}
{"X":56031,"RHEA_ID":59140,"DIRECTION":"UN","MASTER_ID":59140,"ec":"6.3.2.57","compounds":"ATP + citrate + N(5)-[(S)-citryl]-D-ornithine = AMP + diphosphate + H(+) + staphyloferrin A"}
{"X":56032,"RHEA_ID":61663,"compounds":"ATP + geraniol <=> (2E)-geranyl phosphate + ADP + H(+)"}
{"X":56033,"RHEA_ID":60339,"compounds":"N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":56034,"RHEA_ID":58030,"compounds":"a mycoketide-CoA + 10 CO2 + 10 CoA + 11 H2O + 22 NADP(+) => 5 (S)-methylmalonyl-CoA + a medium-chain fatty acyl-CoA + 32 H(+) + 5 malonyl-CoA + 22 NADPH"}
{"X":56035,"RHEA_ID":54693,"DIRECTION":"LR","MASTER_ID":54692,"metacyc":"RXN-18982","compounds":"all-trans-geranylgeranyl diphosphate => (13E)-labda-7,13-dien-15-yl diphosphate"}
{"X":56036,"RHEA_ID":59145,"compounds":"10-formyldihydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide => 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + 7,8-dihydrofolate"}
{"X":56037,"RHEA_ID":61684,"compounds":"glycero-2-phosphocholine + H2O = glycerol + H(+) + phosphocholine"}
{"X":56038,"RHEA_ID":58034,"compounds":"8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":56039,"RHEA_ID":54697,"DIRECTION":"LR","MASTER_ID":54696,"metacyc":"RXN-18535","compounds":"4-hydroxybenzoate + ATP + holo-[4-hydroxyphenylalkanoate synthase] => 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + diphosphate"}
{"X":56040,"RHEA_ID":58036,"compounds":"8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) = 8-epi-inunolide + H2O"}
{"X":56041,"RHEA_ID":58037,"DIRECTION":"LR","MASTER_ID":58036,"metacyc":"RXN-20050","compounds":"8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) => 8-epi-inunolide + H2O"}
{"X":56042,"RHEA_ID":61714,"compounds":"2 [Fe(III)-cytochrome b5] + H2O + N(delta)-methyl-L-arginine => 2 [Fe(II)-cytochrome b5] + 2 H(+) + N(omega)-hydroxy-N(delta)-methyl-L-arginine"}
{"X":56043,"RHEA_ID":61715,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + N(omega)-hydroxy-N(delta)-methyl-L-arginine <=> 2 [Fe(III)-cytochrome b5] + H2O + N(delta)-methyl-L-arginine"}
{"X":56044,"RHEA_ID":60350,"compounds":"H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine"}
{"X":56045,"RHEA_ID":58409,"compounds":"NADP(+) + undecan-1-ol => H(+) + NADPH + undecanal"}
{"X":56046,"RHEA_ID":54704,"compounds":"N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":56047,"RHEA_ID":59172,"compounds":"hexadecanoyl-AMP + holo-[(hydroxy)phthioceranic acid synthase] = AMP + H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase]"}
{"X":56048,"RHEA_ID":55829,"compounds":"cortisol + O2 + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":56049,"RHEA_ID":59173,"DIRECTION":"LR","MASTER_ID":59172,"metacyc":"RXN-18540","compounds":"hexadecanoyl-AMP + holo-[(hydroxy)phthioceranic acid synthase] => AMP + H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase]"}
{"X":56050,"RHEA_ID":60356,"compounds":"H2O + N-octanoylanthranilate = anthranilate + H(+) + octanoate"}
{"X":56051,"RHEA_ID":61723,"compounds":"a D-guloside + NAD(+) <=> a 3-dehydro-D-guloside + H(+) + NADH"}
{"X":56052,"RHEA_ID":58048,"DIRECTION":"UN","MASTER_ID":58048,"ec":"2.3.1.288","compounds":"2-O-sulfo-alpha,alpha-trehalose + octadecanoyl-CoA = 2-O-sulfo-2'-O-octadecanoyl-alpha,alpha-trehalose + CoA"}
{"X":56053,"RHEA_ID":54711,"compounds":"N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":56054,"RHEA_ID":61726,"DIRECTION":"RL","MASTER_ID":61724,"ecocyc":"RXN-20682","metacyc":"RXN-20682","compounds":"a 3-dehydro-D-glucoside + H(+) + NADH => a D-glucoside + NAD(+)"}
{"X":56055,"RHEA_ID":59180,"DIRECTION":"UN","MASTER_ID":59180,"ec":"3.1.4.60","compounds":"5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O = 2 AMP + H(+)"}
{"X":56056,"RHEA_ID":54714,"compounds":"3 H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine => N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine"}
{"X":56057,"RHEA_ID":54715,"compounds":"N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine"}
{"X":56058,"RHEA_ID":61730,"compounds":"a 3-dehydro-D-glucoside => a 3-dehydro-D-guloside"}
{"X":56059,"RHEA_ID":54717,"DIRECTION":"LR","MASTER_ID":54716,"metacyc":"RXN-12890","compounds":"N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":56060,"RHEA_ID":54718,"compounds":"H(+) + N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine"}
{"X":56061,"RHEA_ID":54719,"compounds":"N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":56062,"RHEA_ID":60368,"compounds":"urate(out) = urate(in)"}
{"X":56063,"RHEA_ID":60369,"DIRECTION":"LR","MASTER_ID":60368,"reactome":"R-HSA-2872497.1","compounds":"urate(out) => urate(in)"}
{"X":56064,"RHEA_ID":59189,"compounds":"L-histidine => D-histidine"}
{"X":56065,"RHEA_ID":54723,"compounds":"N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":56066,"RHEA_ID":58062,"compounds":"acetaldehyde + H(+) + sulfite => 2-sulfinoacetaldehyde + H2O"}
{"X":56067,"RHEA_ID":55848,"compounds":"[(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA = [(2->6)-alpha-D-glucosyl-(1->4)-N,7-O-diacetyl-alpha-D-neuraminosyl](n) + n CoA"}
{"X":56068,"RHEA_ID":58064,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + xanthotoxin = 5-hydroxyxanthotoxin + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":56069,"RHEA_ID":58065,"DIRECTION":"LR","MASTER_ID":58064,"metacyc":"RXN-20028","compounds":"O2 + reduced [NADPH--hemoprotein reductase] + xanthotoxin => 5-hydroxyxanthotoxin + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":56070,"RHEA_ID":58066,"compounds":"5-hydroxyxanthotoxin + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + xanthotoxin"}
{"X":56071,"RHEA_ID":54729,"DIRECTION":"LR","MASTER_ID":54728,"ecocyc":"RXN0-5055","metacyc":"RXN0-5055","compounds":"acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] => malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]"}
{"X":56072,"RHEA_ID":58068,"DIRECTION":"UN","MASTER_ID":58068,"ec":"1.13.11.88","compounds":"O2 + trans-isoeugenol = acetaldehyde + vanillin"}
{"X":56073,"RHEA_ID":58069,"DIRECTION":"LR","MASTER_ID":58068,"metacyc":"RXN-20092","compounds":"O2 + trans-isoeugenol => acetaldehyde + vanillin"}
{"X":56074,"RHEA_ID":54732,"compounds":"N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":56075,"RHEA_ID":54733,"DIRECTION":"LR","MASTER_ID":54732,"metacyc":"RXN-13228","compounds":"N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":56076,"RHEA_ID":59217,"DIRECTION":"LR","MASTER_ID":59216,"metacyc":"RXN-20090","compounds":"(indol-3-yl)acetate + H(+) => CO2 + skatole"}
{"X":56077,"RHEA_ID":58073,"compounds":"a 4,5-didehydrojasmonate + H(+) + NADPH => a jasmonate + NADP(+)"}
{"X":56078,"RHEA_ID":60384,"DIRECTION":"UN","MASTER_ID":60384,"ec":"3.1.1.107","compounds":"enterobactin + H2O = N-(2,3-dihydroxybenzoyl)-L-serine trimer"}
{"X":56079,"RHEA_ID":59220,"DIRECTION":"UN","MASTER_ID":59220,"ec":"3.7.1.25","compounds":"(2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + acetate + H(+)"}
{"X":56080,"RHEA_ID":55861,"compounds":"all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-5,6-epoxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":56081,"RHEA_ID":56239,"compounds":"1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine"}
{"X":56082,"RHEA_ID":54740,"compounds":"9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":56083,"RHEA_ID":60389,"DIRECTION":"LR","MASTER_ID":60388,"metacyc":"RXN-20021","compounds":"Fe(III)-di(C-5-deoxy-beta-D-glucosyl)-enterobactin + H2O => Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+)"}
{"X":56084,"RHEA_ID":58080,"compounds":"1-docosanoylglycerol + H2O = docosanoate + glycerol + H(+)"}
{"X":56085,"RHEA_ID":58081,"compounds":"1-docosanoylglycerol + H2O => docosanoate + glycerol + H(+)"}
{"X":56086,"RHEA_ID":58082,"compounds":"docosanoate + glycerol + H(+) => 1-docosanoylglycerol + H2O"}
{"X":56087,"RHEA_ID":54745,"compounds":"9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":56088,"RHEA_ID":54746,"compounds":"18-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":56089,"RHEA_ID":58084,"compounds":"1-(13Z-docosenoyl)-glycerol + H2O = (13Z)-docosenoate + glycerol + H(+)"}
{"X":56090,"RHEA_ID":61762,"compounds":"rebaudioside A + UDP => rebaudioside B + UDP-alpha-D-glucose"}
{"X":56091,"RHEA_ID":60397,"DIRECTION":"LR","MASTER_ID":60396,"metacyc":"RXN-20011","compounds":"Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O => Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine"}
{"X":56092,"RHEA_ID":59233,"DIRECTION":"LR","MASTER_ID":59232,"metacyc":"RXN-20047","compounds":"all-trans-geranylgeranyl diphosphate + H2O => diphosphate + hydropyrenol"}
{"X":56093,"RHEA_ID":55878,"compounds":"apo-[aequorin]--coelenterazine => apo-[aequorin] + coelenterazine"}
{"X":56094,"RHEA_ID":60412,"DIRECTION":"UN","MASTER_ID":60412,"ec":"3.1.1.107","compounds":"H2O + monoglucosyl-enterobactin = [N-(2,3-dihydroxybenzoyl)-L-seryl]2-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine + H(+)"}
{"X":56095,"RHEA_ID":59236,"DIRECTION":"UN","MASTER_ID":59236,"ec":"4.2.3.203","compounds":"all-trans-geranylgeranyl diphosphate = diphosphate + isoelisabethatriene"}
{"X":56096,"RHEA_ID":55881,"DIRECTION":"LR","MASTER_ID":55880,"metacyc":"RXN-18860","compounds":"apo-[aequorin]--coelenterazine + O2 => [aequorin]"}
{"X":56097,"RHEA_ID":58092,"compounds":"1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + glycerol + H(+)"}
{"X":56098,"RHEA_ID":55120,"compounds":"3-oxo-4-methylhexanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxy-4-methylhexanoyl-[ACP] + NADP(+)"}
{"X":56099,"RHEA_ID":58835,"compounds":"24-methylenecycloartanol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}
{"X":56100,"RHEA_ID":60901,"compounds":"a cytidine in RNA + S-adenosyl-L-methionine => an N(3)-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":56101,"RHEA_ID":58098,"compounds":"glycerol + H(+) + tetracosanoate => 1-tetracosanoylglycerol + H2O"}
{"X":56102,"RHEA_ID":59244,"DIRECTION":"UN","MASTER_ID":59244,"ec":"3.1.1.106","compounds":"3''-O-acetyl-ADP-D-ribose + H2O = acetate + ADP-D-ribose + H(+)"}
{"X":56103,"RHEA_ID":60421,"DIRECTION":"LR","MASTER_ID":60420,"metacyc":"RXN-20014","compounds":"H2O + triglucosyl-enterobactin => [N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]3 + H(+)"}
{"X":56104,"RHEA_ID":54763,"compounds":"ATP + H(+) + pyridinium-3,5-dicarboxylate mononucleotide <=> 5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + diphosphate"}
{"X":56105,"RHEA_ID":61778,"compounds":"H(+) + rebaudioside M + UDP => rebaudioside D + UDP-alpha-D-glucose"}
{"X":56106,"RHEA_ID":54765,"DIRECTION":"LR","MASTER_ID":54764,"metacyc":"RXN-19044","compounds":"5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine => [LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+)"}
{"X":56107,"RHEA_ID":61779,"compounds":"rebaudioside D + UDP-alpha-D-glucose <=> H(+) + rebaudioside M + UDP"}
{"X":56108,"RHEA_ID":58104,"compounds":"(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = (14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate"}
{"X":56109,"RHEA_ID":61782,"compounds":"keto-L-sorbose => keto-L-tagatose"}
{"X":56110,"RHEA_ID":58475,"compounds":"2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + O2 <=> CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate"}
{"X":56111,"RHEA_ID":58476,"compounds":"an acyl-CoA + sn-glycerol 3-phosphocholine = a 1-acyl-sn-glycero-3-phosphocholine + CoA"}
{"X":56112,"RHEA_ID":55135,"compounds":"ATP + D-alanine + holo-[D-alanyl-carrier protein] <=> AMP + D-alanyl-[D-alanyl-carrier protein] + diphosphate"}
{"X":56113,"RHEA_ID":56999,"compounds":"aldehydo-D-apiose <=> apulose"}
{"X":56114,"RHEA_ID":54773,"DIRECTION":"LR","MASTER_ID":54772,"metacyc":"RXN-19047","compounds":"ATP + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide => 1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + diphosphate"}
{"X":56115,"RHEA_ID":58112,"compounds":"1''-O-acetyl-ADP-alpha-D-ribose + H2O = acetate + ADP-D-ribose + H(+)"}
{"X":56116,"RHEA_ID":54775,"compounds":"ATP + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide <=> 1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + diphosphate"}
{"X":56117,"RHEA_ID":61814,"compounds":"dehydroepiandrosterone 3-beta-D-glucoside + H(+) + UDP => 3beta-hydroxyandrost-5-en-17-one + UDP-alpha-D-glucose"}
{"X":56118,"RHEA_ID":58483,"compounds":"a cytidine in mRNA + acetyl-CoA + ATP + H2O <=> ADP + an N(4)-acetylcytidine in mRNA + CoA + H(+) + phosphate"}
{"X":56119,"RHEA_ID":58116,"compounds":"L-seryl-[EGF-like domain protein] + UDP-alpha-D-glucose = 3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP"}
{"X":56120,"RHEA_ID":61815,"compounds":"3beta-hydroxyandrost-5-en-17-one + UDP-alpha-D-glucose <=> dehydroepiandrosterone 3-beta-D-glucoside + H(+) + UDP"}
{"X":56121,"RHEA_ID":55144,"DIRECTION":"UN","MASTER_ID":55144,"ec":"1.3.1.113","compounds":"[(3S)-4-(6-methylheptanoyl)-5-oxooxolan-3-yl]methyl phosphate + NADP(+) = [4-(6-methylheptanoyl)-5-oxo-2H-furan-3-yl]methyl phosphate + H(+) + NADPH"}
{"X":56122,"RHEA_ID":54781,"DIRECTION":"LR","MASTER_ID":54780,"metacyc":"RXN-19049","compounds":"[LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine => [LarE protein]-dehydroalanine + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide"}
{"X":56123,"RHEA_ID":55921,"DIRECTION":"LR","MASTER_ID":55920,"metacyc":"RXN-19029","compounds":"[cis-1,4-isoprene](n) + O2 => (4Z,8Z)-4,8-dimethyl-12-oxotrideca-4,8-dienal + cis-1,4-isoprene(n-3)"}
{"X":56124,"RHEA_ID":59266,"compounds":"Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + N-(2,3-dihydroxybenzoyl)-L-serine => Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O"}
{"X":56125,"RHEA_ID":57011,"compounds":"5,5'-dehydrodivanillate + H(+) + NADH + O2 <=> 2,2',3-trihydroxy-3'-methoxy-5,5'-dicarboxybiphenyl + formaldehyde + H2O + NAD(+)"}
{"X":56126,"RHEA_ID":60457,"compounds":"ATP + UTP => 3',3'-cUAMP + 2 diphosphate"}
{"X":56127,"RHEA_ID":55150,"DIRECTION":"RL","MASTER_ID":55148,"metacyc":"RXN-18654","compounds":"a (4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate + H(+) + NADPH => a [(3S)-4-alkanoyl-5-oxooxolan-3-yl]methyl phosphate + NADP(+)"}
{"X":56128,"RHEA_ID":59270,"compounds":"AH2 + formaldehyde + L-lysyl-[protein] => A + H2O + N(6)-methyl-L-lysyl-[protein]"}
{"X":56129,"RHEA_ID":54788,"DIRECTION":"UN","MASTER_ID":54788,"ec":"4.4.1.37","compounds":"[LarE protein]-L-cysteine + ATP + pyridinium-3,5-dicarboxylate mononucleotide = [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide"}
{"X":56130,"RHEA_ID":59272,"compounds":"L-cysteine = D-cysteine"}
{"X":56131,"RHEA_ID":55929,"DIRECTION":"LR","MASTER_ID":55928,"metacyc":"RXN-19054","compounds":"fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] => fenbendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":56132,"RHEA_ID":61828,"compounds":"stigmasterol + UDP-alpha-D-glucose = H(+) + stigmasteryl 3-beta-D-glucoside + UDP"}
{"X":56133,"RHEA_ID":60464,"compounds":"2',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) = 2',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)"}
{"X":56134,"RHEA_ID":54793,"compounds":"7-methyl-GTP + [nsP1 protein]-L-histidine => [nsP1 protein]-N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidine + diphosphate"}
{"X":56135,"RHEA_ID":55933,"compounds":"3-O-(5'-adenylyl)-L-threonyl-[protein] + H2O => AMP + H(+) + L-threonyl-[protein]"}
{"X":56136,"RHEA_ID":59277,"compounds":"L-glutamine => D-glutamine"}
{"X":56137,"RHEA_ID":56296,"compounds":"3-mercaptopyruvate + L-cysteinyl-[protein] = pyruvate + S-sulfanyl-L-cysteinyl-[protein]"}
{"X":56138,"RHEA_ID":54797,"compounds":"a (2R,3S)-2-alkyl-3-hydroxyalkanoate + NADP(+) => an (R)-2-alkyl-3-oxoalkanoate + H(+) + NADPH"}
{"X":56139,"RHEA_ID":58136,"compounds":"acetate + ATP + H(+) = acetyl-AMP + diphosphate"}
{"X":56140,"RHEA_ID":60471,"compounds":"3',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) <=> 3',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)"}
{"X":56141,"RHEA_ID":62214,"compounds":"gentisyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-hydroxybenzyl alcohol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":56142,"RHEA_ID":54801,"compounds":"[nsP1 protein]-N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidine + a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) => [nsP1 protein]-L-histidine + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA"}
{"X":56143,"RHEA_ID":57029,"compounds":"FADH2 + N-methylnicotinate + O2 => (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FAD + H(+)"}
{"X":56144,"RHEA_ID":54803,"compounds":"[nsP1 protein]-N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidine + a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) <=> [nsP1 protein]-L-histidine + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleotide) in mRNA"}
{"X":56145,"RHEA_ID":54804,"DIRECTION":"UN","MASTER_ID":54804,"ec":"1.8.1.20","compounds":"2 4-sulfanylbutanoate + NAD(+) = 4,4'-disulfanyldibutanoate + H(+) + NADH"}
{"X":56146,"RHEA_ID":58143,"compounds":"acetyl-AMP + cytidine(34) in elongator tRNA(Met) <=> AMP + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met)"}
{"X":56147,"RHEA_ID":59289,"compounds":"beta-D-glucosyl-(1<->1)-sphing-4-enine + H2O => D-glucose + sphing-4-enine"}
{"X":56148,"RHEA_ID":58513,"compounds":"1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH => 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)"}
{"X":56149,"RHEA_ID":55172,"compounds":"2-oxoglutarate + hexanoyl-CoA + O2 = 2-hydroxyhexanoyl-CoA + CO2 + succinate"}
{"X":56150,"RHEA_ID":58147,"compounds":"acetate + ATP + cytidine(34) in elongator tRNA(Met) <=> AMP + diphosphate + N(4)-acetylcytidine(34) in elongator tRNA(Met)"}
{"X":56151,"RHEA_ID":57037,"compounds":"[(1->6)-alpha-D-glucosyl](n) + sucrose => (1->3)-alpha-D-glucosyl-[(1->6)-alpha-D-glucosyl]n + D-fructose"}
{"X":56152,"RHEA_ID":58148,"DIRECTION":"UN","MASTER_ID":58148,"ec":"3.1.1.113","compounds":"ethyl acetate + H2O = acetate + ethanol + H(+)"}
{"X":56153,"RHEA_ID":60484,"compounds":"CTP + UTP = cyclic CMP-UMP + 2 diphosphate"}
{"X":56154,"RHEA_ID":58151,"compounds":"ethyl acetate + H2O <=> acetate + ethanol + H(+)"}
{"X":56155,"RHEA_ID":55953,"compounds":"GDP-alpha-D-mannose + inositol phosphoceramide => a mannosylinositol-1-phospho-N-acyl-sphingoid base + GDP + H(+)"}
{"X":56156,"RHEA_ID":61852,"compounds":"campesterol + UDP-alpha-D-glucose = campesteryl 3-beta-D-glucoside + H(+) + UDP"}
{"X":56157,"RHEA_ID":58153,"DIRECTION":"LR","MASTER_ID":58152,"metacyc":"RXN-12513","compounds":"H2O + NAD(+) + phosphonoacetaldehyde => 2 H(+) + NADH + phosphonoacetate"}
{"X":56158,"RHEA_ID":55956,"compounds":"(9Z)-octadecenoate + AH2 + O2 = (12R)-hydroxy-(9Z)-octadecenoate + A + H2O"}
{"X":56159,"RHEA_ID":54818,"compounds":"[protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+) => L-glutaminyl-[protein] + L-lysyl-[protein]"}
{"X":56160,"RHEA_ID":55958,"compounds":"(12R)-hydroxy-(9Z)-octadecenoate + A + H2O => (9Z)-octadecenoate + AH2 + O2"}
{"X":56161,"RHEA_ID":54820,"DIRECTION":"UN","MASTER_ID":54820,"ec":"2.4.1.150","compounds":"a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + UDP-N-acetyl-alpha-D-glucosamine = a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP"}
{"X":56162,"RHEA_ID":58159,"DIRECTION":"BI","MASTER_ID":58156,"metacyc":"3.6.3.15-RXN","compounds":"ATP + H2O + 4 Na(+)(in) <=> ADP + H(+) + 4 Na(+)(out) + phosphate"}
{"X":56163,"RHEA_ID":57049,"DIRECTION":"LR","MASTER_ID":57048,"ecocyc":"TRNA-S-TRANSFERASE-RXN","metacyc":"TRNA-S-TRANSFERASE-RXN","compounds":"AH2 + ATP + cytidine(32) in tRNA + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] => 2-thiocytidine(32) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[cysteine desulfurase]"}
{"X":56164,"RHEA_ID":54823,"compounds":"a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + UDP-N-acetyl-alpha-D-glucosamine <=> a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP"}
{"X":56165,"RHEA_ID":58161,"DIRECTION":"LR","MASTER_ID":58160,"metacyc":"RXN-19635","compounds":"ent-copalyl diphosphate => diphosphate + dolabradiene"}
{"X":56166,"RHEA_ID":60973,"compounds":"hexan-1-ol + NAD(+) => H(+) + hexanal + NADH"}
{"X":56167,"RHEA_ID":57800,"DIRECTION":"UN","MASTER_ID":57800,"ec":"1.14.12.23","metacyc":"RXN-16796","compounds":"2,3-dinitrotoluene + NADH + O2 = 4-methyl-3-nitrocatechol + H(+) + NAD(+) + nitrite"}
{"X":56168,"RHEA_ID":59309,"compounds":"D-galactono-1,5-lactone + H2O => D-galactonate + H(+)"}
{"X":56169,"RHEA_ID":55192,"compounds":"2-oxoglutarate + 3-methyldodecanoyl-CoA + O2 = 2-hydroxy-3-methyldodecanoyl-CoA + CO2 + succinate"}
{"X":56170,"RHEA_ID":61867,"compounds":"AH2 + dehydroprobetaenone I <=> A + probetaenone I"}
{"X":56171,"RHEA_ID":54830,"compounds":"formaldehyde + H2O + methylamine + NADP(+) => dimethylamine + H(+) + NADPH + O2"}
{"X":56172,"RHEA_ID":58170,"compounds":"(-)-5-epi-eremophilene + diphosphate => (2E,6E)-farnesyl diphosphate"}
{"X":56173,"RHEA_ID":61871,"compounds":"1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl-(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatrienoate"}
{"X":56174,"RHEA_ID":54834,"compounds":"a 12-hydroxyjasmonyl-L-alpha-amino acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a jasmonyl-L-amino acid + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":56175,"RHEA_ID":59317,"compounds":"D-cellobiose + O2 => D-cellobiono-1,5-lactone + H2O2"}
{"X":56176,"RHEA_ID":58173,"DIRECTION":"LR","MASTER_ID":58172,"metacyc":"RXN-20045","compounds":"all-trans-geranylgeranyl diphosphate => beta-pinacene + diphosphate"}
{"X":56177,"RHEA_ID":60985,"compounds":"16-hydroxyhexadecanoate + NAD(+) => 16-oxohexadecanoate + H(+) + NADH"}
{"X":56178,"RHEA_ID":55977,"compounds":"glutathione + thiosulfate => H(+) + S-sulfanylglutathione + sulfite"}
{"X":56179,"RHEA_ID":54839,"compounds":"H(+) + heptan-2-one + NADPH + O2 <=> H2O + NADP(+) + pentyl acetate"}
{"X":56180,"RHEA_ID":59323,"compounds":"D-cellobiono-1,5-lactone + H2O <=> 4-O-beta-D-glucopyranosyl-D-gluconate + H(+)"}
{"X":56181,"RHEA_ID":61878,"compounds":"1-O-methyl-8-hydroperoxy-20-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => 1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2"}
{"X":56182,"RHEA_ID":54842,"compounds":"H2O + NADP(+) + pentyl propanoate => H(+) + NADPH + O2 + octan-3-one"}
{"X":56183,"RHEA_ID":59325,"compounds":"D-xylose + O2 => D-xylono-1,5-lactone + H2O2"}
{"X":56184,"RHEA_ID":58550,"compounds":"H2O + 2 monodehydro-L-ascorbate radical + N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine => 2 L-ascorbate + N-(9Z,12Z,15Z)-octadecatrienoylglycine + O2"}
{"X":56185,"RHEA_ID":61881,"compounds":"1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl-12-hydroperoxy-20-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate"}
{"X":56186,"RHEA_ID":60562,"compounds":"S-adenosyl-L-homocysteine + S-methyl-L-methionyl-[protein] => L-methionyl-[protein] + S-adenosyl-L-methionine"}
{"X":56187,"RHEA_ID":59329,"DIRECTION":"LR","MASTER_ID":59328,"metacyc":"RXN-12246","compounds":"D-xylono-1,5-lactone + H2O => D-xylonate + H(+)"}
{"X":56188,"RHEA_ID":60564,"compounds":"2-deoxy-D-glucose + ATP = 2-deoxy-D-glucose 6-phosphate + ADP + H(+)"}
{"X":56189,"RHEA_ID":61887,"compounds":"1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl-9-hydroperoxy-20-hydroxy-(5Z,7E,11Z,14Z)-eicosatetraenoate"}
{"X":56190,"RHEA_ID":55989,"DIRECTION":"LR","MASTER_ID":55988,"metacyc":"3.2.1.106-RXN","compounds":"H2O + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] => beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein]"}
{"X":56191,"RHEA_ID":54851,"compounds":"H(+) + hexan-3-one + NADPH + O2 <=> H2O + NADP(+) + propyl propanoate"}
{"X":56192,"RHEA_ID":58190,"compounds":"dihydroisopentenyldehydrorhodopin + diphosphate => all-trans-lycopene + dimethylallyl diphosphate + H2O"}
{"X":56193,"RHEA_ID":58558,"compounds":"(16S)-deshydroxymethyl-stemmadenine + formate => 15alpha-stemmadenine intermediate II + H2O"}
{"X":56194,"RHEA_ID":55993,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)"}
{"X":56195,"RHEA_ID":59337,"compounds":"1-hydroxy-all-trans-1,2-dihydro-neurosporene + A => AH2 + demethylspheroidene"}
{"X":56196,"RHEA_ID":55220,"DIRECTION":"UN","MASTER_ID":55220,"ec":"1.14.18.9","compounds":"4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 = 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate + 6 [Fe(III)-cytochrome b5] + 4 H2O"}
{"X":56197,"RHEA_ID":56357,"DIRECTION":"LR","MASTER_ID":56356,"metacyc":"RXN-19062","compounds":"3-bromo-4-hydroxybenzoate + bromide + 3 H(+) + NADPH + O2 => 2,4-dibromophenol + CO2 + 2 H2O + NADP(+)"}
{"X":56198,"RHEA_ID":55997,"DIRECTION":"LR","MASTER_ID":55996,"metacyc":"RXN-18907","compounds":"H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] => beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein]"}
{"X":56199,"RHEA_ID":54859,"compounds":"H(+) + NADPH + O2 + octan-3-one <=> ethyl hexanoate + H2O + NADP(+)"}
{"X":56200,"RHEA_ID":61902,"compounds":"A + betaenone B => AH2 + betaenone C"}
{"X":56201,"RHEA_ID":58199,"compounds":"H2O + N(6)-acetyl-L-lysyl-[histone] <=> acetate + L-lysyl-[histone]"}
{"X":56202,"RHEA_ID":54862,"compounds":"(1E)-2,6-dimethylhepta-1,5-dien-1-yl formate + H2O + NADP(+) => geranial + H(+) + NADPH + O2"}
{"X":56203,"RHEA_ID":54863,"compounds":"geranial + H(+) + NADPH + O2 <=> (1E)-2,6-dimethylhepta-1,5-dien-1-yl formate + H2O + NADP(+)"}
{"X":56204,"RHEA_ID":57091,"compounds":"an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O <=> 3-beta-D-galactosyl-sn-glycerol + a fatty acid + H(+)"}
{"X":56205,"RHEA_ID":61906,"compounds":"H2O + NADP(+) + stemphyloxin II => betaenone A + H(+) + NADPH + O2"}
{"X":56206,"RHEA_ID":54866,"compounds":"4-methylpent-3-en-1-yl acetate + H2O + NADP(+) => H(+) + NADPH + O2 + sulcatone"}
{"X":56207,"RHEA_ID":54867,"compounds":"H(+) + NADPH + O2 + sulcatone <=> 4-methylpent-3-en-1-yl acetate + H2O + NADP(+)"}
{"X":56208,"RHEA_ID":54868,"compounds":"(2E)-butenoyl-[ACP] + H(+) + NADH = butanoyl-[ACP] + NAD(+)"}
{"X":56209,"RHEA_ID":61910,"compounds":"2 AMP + asperphenamate + 2 diphosphate + H(+) => 2 ATP + benzoate + L-phenylalanine + N-benzoyl-L-phenylalaninol"}
{"X":56210,"RHEA_ID":62288,"compounds":"(8aS)-3-[(1H-indol-3-yl)methyl]-1H,2H,6H,7H,8H,8aH-pyrrolo[1,2-a]pyrazin-1-one + dimethylallyl diphosphate = (8aS)-3-{[2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl]methyl}-1H,2H,6H,7H,8H,8aH-pyrrolo[1,2-a]pyrazin-1-one + diphosphate"}
{"X":56211,"RHEA_ID":54871,"compounds":"(2E)-butenoyl-[ACP] + H(+) + NADH <=> butanoyl-[ACP] + NAD(+)"}
{"X":56212,"RHEA_ID":61914,"compounds":"ADP + H(+) + phosphate + voriconazole(out) => ATP + H2O + voriconazole(in)"}
{"X":56213,"RHEA_ID":54873,"DIRECTION":"LR","MASTER_ID":54872,"metacyc":"RXN-9442","compounds":"(1S,4R)-menthone + H(+) + NADPH + O2 => (4S,7R)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)"}
{"X":56214,"RHEA_ID":54874,"compounds":"(4S,7R)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+) => (1S,4R)-menthone + H(+) + NADPH + O2"}
{"X":56215,"RHEA_ID":54875,"compounds":"(1S,4R)-menthone + H(+) + NADPH + O2 <=> (4S,7R)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)"}
{"X":56216,"RHEA_ID":57103,"compounds":"5-methylsulfanyl-D-ribulose 1-phosphate <=> 1-methylsulfanyl-D-xylulose 5-phosphate"}
{"X":56217,"RHEA_ID":58582,"compounds":"acetate + catharanthine + H(+) => dihydroprecondylocarpine acetate"}
{"X":56218,"RHEA_ID":54878,"compounds":"(3S)-3-isopropenyl-6-oxoheptanoate + H(+) => (4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one"}
{"X":56219,"RHEA_ID":59361,"DIRECTION":"LR","MASTER_ID":59360,"metacyc":"3.4.13.20-RXN","compounds":"carnosine + H2O => beta-alanine + L-histidine"}
{"X":56220,"RHEA_ID":58219,"compounds":"A + dihydroserpentine <=> AH2 + serpentine"}
{"X":56221,"RHEA_ID":54882,"compounds":"(3R)-3-isopropenyl-6-oxoheptanoate + H(+) => (4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one"}
{"X":56222,"RHEA_ID":55247,"compounds":"4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}
{"X":56223,"RHEA_ID":57110,"compounds":"1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}
{"X":56224,"RHEA_ID":57479,"compounds":"dodecanoate + H2O2 <=> 2-hydroxydodecanoate + H2O"}
{"X":56225,"RHEA_ID":59368,"compounds":"1-octadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O = 1-octadecanoyl-sn-glycero-3-phosphoserine + 10-hydroxyoctadecanoate + H(+)"}
{"X":56226,"RHEA_ID":59369,"compounds":"1-octadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O => 1-octadecanoyl-sn-glycero-3-phosphoserine + 10-hydroxyoctadecanoate + H(+)"}
{"X":56227,"RHEA_ID":61930,"compounds":"(R)-miconazole(out) + ADP + H(+) + phosphate => (R)-miconazole(in) + ATP + H2O"}
{"X":56228,"RHEA_ID":58227,"compounds":"L-glutamyl-[protein] + NAD(+) <=> 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide"}
{"X":56229,"RHEA_ID":54890,"compounds":"AMP + diphosphate + OPC-8-CoA => ATP + CoA + OPC-8"}
{"X":56230,"RHEA_ID":60631,"compounds":"AH2 + gluconapin + O2 <=> A + H2O + xi-progoitrin"}
{"X":56231,"RHEA_ID":57118,"compounds":"1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}
{"X":56232,"RHEA_ID":58231,"compounds":"L-asparaginyl-[protein] + NAD(+) <=> H(+) + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] + nicotinamide"}
{"X":56233,"RHEA_ID":58232,"compounds":"L-seryl-[protein] + NAD(+) = H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein]"}
{"X":56234,"RHEA_ID":58233,"compounds":"L-seryl-[protein] + NAD(+) => H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein]"}
{"X":56235,"RHEA_ID":59378,"compounds":"4-amino-4-deoxyprephenate => 4-amino-4-deoxychorismate"}
{"X":56236,"RHEA_ID":57123,"compounds":"1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine"}
{"X":56237,"RHEA_ID":54898,"compounds":"(10Z,15Z)-12-oxophytodienoyl-CoA + AMP + diphosphate => (10Z,15Z)-12-oxophytodienoate + ATP + CoA"}
{"X":56238,"RHEA_ID":54899,"compounds":"(10Z,15Z)-12-oxophytodienoate + ATP + CoA <=> (10Z,15Z)-12-oxophytodienoyl-CoA + AMP + diphosphate"}
{"X":56239,"RHEA_ID":58237,"compounds":"L-tyrosyl-[protein] + NAD(+) => H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-tyrosyl-[protein]"}
{"X":56240,"RHEA_ID":55265,"DIRECTION":"LR","MASTER_ID":55264,"metacyc":"RXN-20357","compounds":"1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine => di-(9Z,12Z)-octadecadienoylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine"}
{"X":56241,"RHEA_ID":62320,"compounds":"(+)-premalbrancheamide + chloride + FAD + 2 H(+) = (+)-isomalbrancheamide B + FADH2"}
{"X":56242,"RHEA_ID":55267,"compounds":"1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine <=> di-(9Z,12Z)-octadecadienoylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine"}
{"X":56243,"RHEA_ID":59386,"compounds":"3-(4-aminophenyl)pyruvate + L-glutamate => 2-oxoglutarate + 4-amino-L-phenylalanine"}
{"X":56244,"RHEA_ID":60649,"compounds":"an N-(acyl)-sphingosylphosphoethanolamine => an N-(acyl)-sphingosyl-1,3-cyclic phosphate + ethanolamine"}
{"X":56245,"RHEA_ID":62324,"compounds":"(+)-malbrancheamide B + chloride + FAD + 2 H(+) = (+)-malbrancheamide + FADH2"}
{"X":56246,"RHEA_ID":58244,"compounds":"H2O + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] = ADP-D-ribose + L-lysyl-[protein]"}
{"X":56247,"RHEA_ID":58245,"compounds":"H2O + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] => ADP-D-ribose + L-lysyl-[protein]"}
{"X":56248,"RHEA_ID":54909,"compounds":"(2E,4E)-hexadienoyl-CoA + H(+) + NADPH => (4E)-hexenoyl-CoA + NADP(+)"}
{"X":56249,"RHEA_ID":58248,"compounds":"5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + H2O = ADP-D-ribose + H(+) + L-glutamyl-[protein]"}
{"X":56250,"RHEA_ID":59392,"compounds":"acetyl-CoA + L-seryl-[protein] = CoA + O-acetyl-L-seryl-[protein]"}
{"X":56251,"RHEA_ID":58249,"compounds":"5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + H2O => ADP-D-ribose + H(+) + L-glutamyl-[protein]"}
{"X":56252,"RHEA_ID":57139,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphoserine"}
{"X":56253,"RHEA_ID":56053,"DIRECTION":"LR","MASTER_ID":56052,"metacyc":"3.2.1.114-RXN","compounds":"2 H2O + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => 2 alpha-D-mannopyranose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]"}
{"X":56254,"RHEA_ID":61956,"compounds":"1-O-octadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + AH2 + O2 = 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + A + 2 H2O"}
{"X":56255,"RHEA_ID":54917,"compounds":"9-cis-retinol + NADP(+) => 9-cis-retinal + H(+) + NADPH"}
{"X":56256,"RHEA_ID":54918,"compounds":"9-cis-retinal + H(+) + NADPH => 9-cis-retinol + NADP(+)"}
{"X":56257,"RHEA_ID":61961,"compounds":"a 1-O-hexadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + AH2 + O2 => A + a 1-O-(1Z-hexadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 H2O"}
{"X":56258,"RHEA_ID":57146,"compounds":"1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine"}
{"X":56259,"RHEA_ID":57147,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine <=> 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)"}
{"X":56260,"RHEA_ID":54922,"compounds":"13-cis-retinal + H(+) + NADPH => 13-cis-retinol + NADP(+)"}
{"X":56261,"RHEA_ID":54923,"compounds":"13-cis-retinol + NADP(+) <=> 13-cis-retinal + H(+) + NADPH"}
{"X":56262,"RHEA_ID":56063,"compounds":"H(+) + hexadecanoate + hnu <=> CO2 + pentadecane"}
{"X":56263,"RHEA_ID":59407,"DIRECTION":"BI","MASTER_ID":59404,"metacyc":"RXN0-7285","compounds":"L-homoserine <=> D-homoserine"}
{"X":56264,"RHEA_ID":62344,"compounds":"6-hydroxydeoxybrevianamide E + dimethylallyl diphosphate = diphosphate + notoamide S"}
{"X":56265,"RHEA_ID":54927,"compounds":"(7Z)-tetradecenoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxo-(9Z)-hexadecenoyl-[ACP] + CO2 + holo-[ACP]"}
{"X":56266,"RHEA_ID":58266,"compounds":"an N-acylsphing-4-enine + cholesteryl 3-beta-D-glucoside => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol"}
{"X":56267,"RHEA_ID":60673,"compounds":"NAD(+) + nerol => H(+) + NADH + neral"}
{"X":56268,"RHEA_ID":54930,"compounds":"(3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] + NADP(+) => 3-oxo-(9Z)-hexadecenoyl-[ACP] + H(+) + NADPH"}
{"X":56269,"RHEA_ID":61972,"compounds":"1-O-(13-methyltetradecyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + AH2 + O2 = 1-O-(1Z-13-methyltetradecenyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + A + 2 H2O"}
{"X":56270,"RHEA_ID":57158,"compounds":"4-hydroxy-L-lysyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-lysyl-[protein] + O2"}
{"X":56271,"RHEA_ID":57159,"compounds":"2-oxoglutarate + L-lysyl-[protein] + O2 <=> 4-hydroxy-L-lysyl-[protein] + CO2 + succinate"}
{"X":56272,"RHEA_ID":61976,"compounds":"glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine = 5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin]"}
{"X":56273,"RHEA_ID":54935,"compounds":"(3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] <=> (2E,9Z)-hexadecadienoyl-[ACP] + H2O"}
{"X":56274,"RHEA_ID":58277,"compounds":"6 ATP => cyclic hexaadenylate + 6 diphosphate"}
{"X":56275,"RHEA_ID":60680,"compounds":"(+)-artemisinic aldehyde + H2O + NADP(+) = (+)-artemisinate + 2 H(+) + NADPH"}
{"X":56276,"RHEA_ID":56076,"compounds":"an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)"}
{"X":56277,"RHEA_ID":54939,"compounds":"(2E)-decenoyl-[ACP] + H(+) + NADH <=> decanoyl-[ACP] + NAD(+)"}
{"X":56278,"RHEA_ID":58282,"compounds":"cyclic tetraadenylate + 4 diphosphate => 4 ATP"}
{"X":56279,"RHEA_ID":59424,"compounds":"benzylamine + H2O + O2 = benzaldehyde + H2O2 + NH4(+)"}
{"X":56280,"RHEA_ID":54943,"compounds":"(3Z)-decenoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxo-(5Z)-dodecenoyl-[ACP] + CO2 + holo-[ACP]"}
{"X":56281,"RHEA_ID":58286,"DIRECTION":"RL","MASTER_ID":58284,"reactome":"R-HSA-73616.2","compounds":"H(+) + NADPH + thymine => 5,6-dihydrothymine + NADP(+)"}
{"X":56282,"RHEA_ID":56808,"compounds":"ATP + cob(I)yrinate a,c diamide--[corrinoid adenosyltransferase] = adenosylcob(III)yrinate a,c-diamide + apo-[corrinoid adenosyltransferase] + triphosphate"}
{"X":56283,"RHEA_ID":62362,"compounds":"(Z)-3-ureidoacrylate + FMN-N(5)-oxide + 2 H(+) => FMNH2 + O2 + uracil"}
{"X":56284,"RHEA_ID":56085,"compounds":"[Rab1 protein]-O-phosphocholine-L-serine + H2O => [Rab1 protein]-L-serine + H(+) + phosphocholine"}
{"X":56285,"RHEA_ID":61989,"compounds":"cytidine(72) in tRNA + S-adenosyl-L-methionine => 5-methylcytidine(72) in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":56286,"RHEA_ID":58658,"compounds":"a 5'-(5'-phosphomethyl)-ribonucleoside-RNA + S-adenosyl-L-homocysteine => a 5'-(5'-phospho)-ribonucleoside-RNA + S-adenosyl-L-methionine"}
{"X":56287,"RHEA_ID":62366,"compounds":"(Z)-2-methylureidoacrylate + FMN-N(5)-oxide + 2 H(+) => FMNH2 + O2 + thymine"}
{"X":56288,"RHEA_ID":54951,"compounds":"(3R)-hydroxy-(5Z)-dodecenoyl-[ACP] <=> (2E,5Z)-dodecadienoyl-[ACP] + H2O"}
{"X":56289,"RHEA_ID":55316,"compounds":"3 H2O + hydrogen sulfide + 3 NAD(+) = 4 H(+) + 3 NADH + sulfite"}
{"X":56290,"RHEA_ID":60697,"compounds":"(R)-lavandulyl diphosphate + H2O => (R)-lavandulol + diphosphate"}
{"X":56291,"RHEA_ID":54954,"compounds":"AMP + diphosphate + nonanoyl-CoA => ATP + CoA + nonanoate"}
{"X":56292,"RHEA_ID":56093,"compounds":"bilirubin IXalpha + H(+) + oxidized coenzyme F420-(gamma-Glu)(n) => biliverdin IXalpha + reduced coenzyme F420-(gamma-Glu)(n)"}
{"X":56293,"RHEA_ID":57182,"compounds":"N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein] => L-lysyl-[protein] + methylglyoxal"}
{"X":56294,"RHEA_ID":58299,"compounds":"25-substituted-cholesterol + beta-D-glucosyl-N-hexadecanoylsphing-4E-enine <=> 25-substituted-cholesteryl beta-D-glucoside + N-hexadecanoylsphing-4-enine"}
{"X":56295,"RHEA_ID":59448,"compounds":"dodecan-1-ol + NADP(+) = dodecanal + H(+) + NADPH"}
{"X":56296,"RHEA_ID":54959,"compounds":"ATP + CoA + OPC-6 <=> AMP + diphosphate + OPC-6-CoA"}
{"X":56297,"RHEA_ID":62002,"compounds":"3 AH2 + protoporphyrin IX => 3 A + protoporphyrinogen IX"}
{"X":56298,"RHEA_ID":58303,"compounds":"25-substituted-cholesterol + beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine <=> 25-substituted-cholesteryl beta-D-glucoside + N-octadecanoylsphing-4-enine"}
{"X":56299,"RHEA_ID":58672,"compounds":"D-glucuronate = aldehydo-D-glucuronate"}
{"X":56300,"RHEA_ID":59453,"compounds":"a long-chain primary fatty alcohol + NADP(+) => a long-chain fatty aldehyde + H(+) + NADPH"}
{"X":56301,"RHEA_ID":58305,"compounds":"25-substituted-cholesterol + beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine => 25-substituted-cholesteryl beta-D-glucoside + N-(9Z-octadecenoyl)-sphing-4-enine"}
{"X":56302,"RHEA_ID":60708,"compounds":"(1R,3R)-chrysanthemal + H2O + NAD(+) = (1R,3R)-chrysanthemate + 2 H(+) + NADH"}
{"X":56303,"RHEA_ID":54966,"compounds":"hexadecanoyl phosphate + holo-[ACP] => hexadecanoyl-[ACP] + phosphate"}
{"X":56304,"RHEA_ID":55334,"compounds":"a 3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine => a 3'-hydroxyflavone + S-adenosyl-L-methionine"}
{"X":56305,"RHEA_ID":57194,"compounds":"glycolate + H(+) + L-lysyl-[protein] => H2O + N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein]"}
{"X":56306,"RHEA_ID":54969,"compounds":"hexadecanoyl phosphate + sn-glycerol 3-phosphate => 1-hexadecanoyl-sn-glycero-3-phosphate + phosphate"}
{"X":56307,"RHEA_ID":54970,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphate + phosphate => hexadecanoyl phosphate + sn-glycerol 3-phosphate"}
{"X":56308,"RHEA_ID":58312,"compounds":"25-substituted-cholesteryl beta-D-glucoside + H2O = 25-substituted-cholesterol + D-glucose"}
{"X":56309,"RHEA_ID":55339,"compounds":"a 5'-hydroxy-3'-methoxyflavone + S-adenosyl-L-methionine <=> a 3',5'-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine"}
{"X":56310,"RHEA_ID":60716,"compounds":"(1R,3R)-chrysanthemal + H2O + NADP(+) = (1R,3R)-chrysanthemate + 2 H(+) + NADPH"}
{"X":56311,"RHEA_ID":54974,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphate + holo-[ACP] => 1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-[ACP]"}
{"X":56312,"RHEA_ID":59867,"compounds":"(indol-3-yl)butanoate + ATP + L-glutamine <=> (indol-3-yl)butanoyl-L-glutamine + AMP + diphosphate + H(+)"}
{"X":56313,"RHEA_ID":59868,"compounds":"4-(2,4-dichlorophenoxy)butanoate + ATP + L-glutamine = 4-(2,4-dichlorophenoxy)butanoyl-L-glutamine + AMP + diphosphate + H(+)"}
{"X":56314,"RHEA_ID":57203,"compounds":"glyoxal + L-arginyl-[protein] <=> N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein]"}
{"X":56315,"RHEA_ID":59468,"DIRECTION":"UN","MASTER_ID":59468,"ec":"3.4.19.13","compounds":"an S-substituted glutathione + H2O = an S-substitued L-cysteinylglycine + L-glutamate"}
{"X":56316,"RHEA_ID":59871,"compounds":"4-(2,4-dichlorophenoxy)butanoate + ATP + L-glutamine <=> 4-(2,4-dichlorophenoxy)butanoyl-L-glutamine + AMP + diphosphate + H(+)"}
{"X":56317,"RHEA_ID":55347,"compounds":"(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-mono-(9Z-octadecenoyl)-glycerol <=> 1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerol + CoA"}
{"X":56318,"RHEA_ID":59472,"compounds":"2',3'-cGAMP + H2O = Gp(2'-5')Ap(3') + H(+)"}
{"X":56319,"RHEA_ID":58324,"compounds":"beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-(9Z-octadecenoyl)-sphing-4-enine"}
{"X":56320,"RHEA_ID":59876,"compounds":"(indol-3-yl)butanoate + ATP + L-cysteine = (indol-3-yl)butanoyl-L-cysteine + AMP + diphosphate + H(+)"}
{"X":56321,"RHEA_ID":59475,"compounds":"2',3'-cGAMP + H2O <=> Gp(2'-5')Ap(3') + H(+)"}
{"X":56322,"RHEA_ID":58696,"compounds":"NADPH + O2 + rifampicin = H(+) + H2O + NADP(+) + rifampicin para-naphthoquinone carboxamide"}
{"X":56323,"RHEA_ID":55354,"compounds":"13-cis-retinol => all-trans-retinol"}
{"X":56324,"RHEA_ID":62486,"compounds":"2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O"}
{"X":56325,"RHEA_ID":54989,"compounds":"4 e(-) + 4 H(+)(in) + O2(in) => 2 H2O(in)"}
{"X":56326,"RHEA_ID":58700,"compounds":"FADH2-C4alpha-hydroperoxide + NADPH + rifampicin = FADH2 + H(+) + H2O + NADP(+) + rifampicin hemiaminal"}
{"X":56327,"RHEA_ID":55358,"compounds":"13-cis-retinol => 11-cis-retinol"}
{"X":56328,"RHEA_ID":54992,"DIRECTION":"UN","MASTER_ID":54992,"ec":"2.6.1.114","compounds":"3 A + FMN + H2O + L-glutamate + O2 = 2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 3 AH2 + CO2 + H(+)"}
{"X":56329,"RHEA_ID":54993,"DIRECTION":"LR","MASTER_ID":54992,"metacyc":"RXN-18512","compounds":"3 A + FMN + H2O + L-glutamate + O2 => 2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 3 AH2 + CO2 + H(+)"}
{"X":56330,"RHEA_ID":62036,"compounds":"a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)"}
{"X":56331,"RHEA_ID":62037,"compounds":"a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O => a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)"}
{"X":56332,"RHEA_ID":60740,"compounds":"(S)-(-)-citronellal + H2O + NADP(+) = (S)-(-)-citronellate + 2 H(+) + NADPH"}
{"X":56333,"RHEA_ID":54997,"DIRECTION":"LR","MASTER_ID":54996,"metacyc":"RXN-16324","compounds":"3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate => 3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP"}
{"X":56334,"RHEA_ID":62040,"compounds":"H2O + N-(octanoyl)-sphing-4-enine-1-phosphate = N-octanoylsphing-4-enine + phosphate"}
{"X":56335,"RHEA_ID":55366,"compounds":"all-trans-nonaprenyl diphosphate + 6 diphosphate => (2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate"}
{"X":56336,"RHEA_ID":60744,"compounds":"(1R,3R)-chrysanthemoyl-CoA + (Z,S)-pyrethrolone = CoA + pyrethrin I"}
{"X":56337,"RHEA_ID":58343,"compounds":"beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O <=> chenodeoxycholate + D-glucose"}
{"X":56338,"RHEA_ID":59496,"compounds":"(20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + O2 + reduced [NADPH--hemoprotein reductase] = (20S)-ginsenoside C-K + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":56339,"RHEA_ID":58713,"compounds":"NADH + O2 + rifampicin => H(+) + H2O + NAD(+) + rifampicin para-naphthoquinone carboxamide"}
{"X":56340,"RHEA_ID":55004,"DIRECTION":"UN","MASTER_ID":55004,"ec":"1.14.13.105","compounds":"1-hydroxylimonen-2-one + NADPH + O2 = 3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)"}
{"X":56341,"RHEA_ID":55005,"DIRECTION":"LR","MASTER_ID":55004,"metacyc":"RXN-15253","compounds":"1-hydroxylimonen-2-one + NADPH + O2 => 3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)"}
{"X":56342,"RHEA_ID":59500,"DIRECTION":"UN","MASTER_ID":59500,"ec":"3.6.1.52","compounds":"5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H(+) + phosphate"}
{"X":56343,"RHEA_ID":58717,"compounds":"FADH2-C4alpha-hydroperoxide + NADH + rifampicin => FADH2 + H(+) + H2O + NAD(+) + rifampicin hemiaminal"}
{"X":56344,"RHEA_ID":55008,"compounds":"(1R,4S)-1-hydroxylimonen-2-one + NADPH + O2 = (3S)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)"}
{"X":56345,"RHEA_ID":59503,"compounds":"5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O <=> 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H(+) + phosphate"}
{"X":56346,"RHEA_ID":59504,"compounds":"cholesterol + glycyl-L-cysteinyl-[protein] + H(+) = [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein]"}
{"X":56347,"RHEA_ID":58353,"compounds":"2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + O2 => CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate"}
{"X":56348,"RHEA_ID":55012,"compounds":"(1S,4R)-1-hydroxylimonen-2-one + NADPH + O2 = (3R)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)"}
{"X":56349,"RHEA_ID":55013,"DIRECTION":"LR","MASTER_ID":55012,"metacyc":"RXN-15254","compounds":"(1S,4R)-1-hydroxylimonen-2-one + NADPH + O2 => (3R)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)"}
{"X":56350,"RHEA_ID":55385,"compounds":"(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 6 isopentenyl diphosphate => 6 diphosphate + tetra-trans,hexa-cis-undecaprenyl diphosphate"}
{"X":56351,"RHEA_ID":55386,"compounds":"6 diphosphate + tetra-trans,hexa-cis-undecaprenyl diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 6 isopentenyl diphosphate"}
{"X":56352,"RHEA_ID":62530,"compounds":"2 [Fe(III)cytochrome c] + dihydrodigoxin => 2 [Fe(II)cytochrome c] + digoxin + 3 H(+)"}
{"X":56353,"RHEA_ID":55017,"DIRECTION":"LR","MASTER_ID":55016,"metacyc":"RXN-9440","compounds":"H(+) + menthone + NADPH + O2 => 7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)"}
{"X":56354,"RHEA_ID":58359,"compounds":"2-oxoglutarate + N(omega)-methyl-L-arginyl-[protein] + O2 <=> CO2 + formaldehyde + L-arginyl-[protein] + succinate"}
{"X":56355,"RHEA_ID":58361,"compounds":"2-oxoglutarate + L-lysyl-[protein] + O2 => (5S)-5-hydroxy-L-lysyl-[protein] + CO2 + succinate"}
{"X":56356,"RHEA_ID":55020,"compounds":"5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O = 5,6-diaminouracil + D-ribose 5-phosphate"}
{"X":56357,"RHEA_ID":55021,"compounds":"5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O => 5,6-diaminouracil + D-ribose 5-phosphate"}
{"X":56358,"RHEA_ID":58732,"compounds":"5-methyl-CTP + H2O = 5-methyl-CMP + diphosphate + H(+)"}
{"X":56359,"RHEA_ID":55023,"compounds":"5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O <=> 5,6-diaminouracil + D-ribose 5-phosphate"}
{"X":56360,"RHEA_ID":58366,"compounds":"a medium-chain fatty aldehyde + H(+) + NADPH => a medium-chain primary fatty alcohol + NADP(+)"}
{"X":56361,"RHEA_ID":55025,"DIRECTION":"LR","MASTER_ID":55024,"metacyc":"RXN-18615","compounds":"(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] => (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":56362,"RHEA_ID":56164,"compounds":"(9Z,12Z,15Z)-octadecatrienoyl-CoA + sn-glycerol 3-phosphocholine = (9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":56363,"RHEA_ID":59521,"compounds":"ATP + butanoyl-CoA + hydrogencarbonate => (2S)-ethylmalonyl-CoA + ADP + H(+) + phosphate"}
{"X":56364,"RHEA_ID":62069,"compounds":"2-deoxy-D-glucose 6-phosphate + NADP(+) => 2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADPH"}
{"X":56365,"RHEA_ID":58371,"compounds":"(2E,6Z)-nona-2,6-dien-1-ol + NADP(+) <=> (2E,6Z)-nona-2,6-dienal + H(+) + NADPH"}
{"X":56366,"RHEA_ID":62070,"compounds":"2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADPH => 2-deoxy-D-glucose 6-phosphate + NADP(+)"}
{"X":56367,"RHEA_ID":56169,"compounds":"(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":56368,"RHEA_ID":58374,"compounds":"(2E)-octenal + H(+) + NADPH => (E)-oct-2-en-1-ol + NADP(+)"}
{"X":56369,"RHEA_ID":58375,"compounds":"(E)-oct-2-en-1-ol + NADP(+) <=> (2E)-octenal + H(+) + NADPH"}
{"X":56370,"RHEA_ID":58744,"compounds":"7-methyl-GTP + H2O = 7-methyl-GMP + diphosphate + H(+)"}
{"X":56371,"RHEA_ID":59529,"compounds":"hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein] => CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]"}
{"X":56372,"RHEA_ID":58378,"compounds":"decanal + H(+) + NADPH => decan-1-ol + NADP(+)"}
{"X":56373,"RHEA_ID":55037,"DIRECTION":"LR","MASTER_ID":55036,"metacyc":"RXN-18676","compounds":"an N,N-dimethylornithine lipid + S-adenosyl-L-methionine => an N,N,N-trimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine"}
{"X":56374,"RHEA_ID":60802,"compounds":"CO2 + gibberellin A44 + succinate => 2-oxoglutarate + gibberellin A53 + O2"}
{"X":56375,"RHEA_ID":59532,"compounds":"(S)-reticuline + S-adenosyl-L-methionine = (S)-codamine + H(+) + S-adenosyl-L-homocysteine"}
{"X":56376,"RHEA_ID":62082,"compounds":"6-sulfo-D-glucono-1,5-lactone + H(+) + NADPH => D-glucose 6-sulfate + NADP(+)"}
{"X":56377,"RHEA_ID":55041,"compounds":"(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]"}
{"X":56378,"RHEA_ID":57268,"compounds":"H2O + N(2)-(1-hydroxy-2-oxopropyl)-GMP = GMP + H(+) + lactate"}
{"X":56379,"RHEA_ID":59537,"compounds":"ATP + butanoyl-CoA + hydrogencarbonate => (2R)-ethylmalonyl-CoA + ADP + H(+) + phosphate"}
{"X":56380,"RHEA_ID":58386,"compounds":"H(+) + NADPH + octanal => NADP(+) + octan-1-ol"}
{"X":56381,"RHEA_ID":55045,"compounds":"(3E,5Z)-tetradecadienoyl-CoA + H2O => (3E,5Z)-tetradecadienoate + CoA + H(+)"}
{"X":56382,"RHEA_ID":62088,"compounds":"D-glucosamine 6-phosphate + NADP(+) = 2-amino-2-deoxy-6-phospho-D-glucono-1,5-lactone + 2 H(+) + NADPH"}
{"X":56383,"RHEA_ID":56185,"compounds":"globoside Gb4Cer + UDP-alpha-D-galactose => globoside NOR1 + H(+) + UDP"}
{"X":56384,"RHEA_ID":62089,"compounds":"D-glucosamine 6-phosphate + NADP(+) => 2-amino-2-deoxy-6-phospho-D-glucono-1,5-lactone + 2 H(+) + NADPH"}
{"X":56385,"RHEA_ID":55049,"compounds":"(3E,5Z)-dodecadienoyl-CoA + H2O => (3E,5Z)-dodecadienoate + CoA + H(+)"}
{"X":56386,"RHEA_ID":57276,"compounds":"a 2'-deoxyguanosine in DNA + glyoxal = an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA"}
{"X":56387,"RHEA_ID":59544,"compounds":"N,N'-diacetylchitobiose + O2 = H2O2 + N,N'-diacetylchitobiono-1,5-lactone"}
{"X":56388,"RHEA_ID":58394,"compounds":"4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 4-amino-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]"}
{"X":56389,"RHEA_ID":55053,"compounds":"H2O + pentanoyl-CoA => CoA + H(+) + pentanoate"}
{"X":56390,"RHEA_ID":56192,"DIRECTION":"UN","MASTER_ID":56192,"ec":"2.4.1.148","compounds":"3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP"}
{"X":56391,"RHEA_ID":58396,"compounds":"4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + 5 H(+) + O2 + 4 reduced [2Fe-2S]-[ferredoxin] = 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + NH4(+) + 4 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":56392,"RHEA_ID":60832,"DIRECTION":"UN","MASTER_ID":60832,"ec":"3.1.3.33","compounds":"a 5'-end triphospho-guanosine in mRNA + H2O = a 5'-end diphospho-guanosine in mRNA + H(+) + phosphate"}
{"X":56393,"RHEA_ID":57283,"compounds":"a guanosine in RNA + glyoxal <=> an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA"}
{"X":56394,"RHEA_ID":56196,"compounds":"3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-alpha-D-galactose = H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP"}
{"X":56395,"RHEA_ID":58401,"compounds":"heptan-1-ol + NADP(+) => H(+) + heptanal + NADPH"}
{"X":56396,"RHEA_ID":58402,"compounds":"H(+) + heptanal + NADPH => heptan-1-ol + NADP(+)"}
{"X":56397,"RHEA_ID":55061,"DIRECTION":"LR","MASTER_ID":55060,"metacyc":"RXN-18491","compounds":"a 12-hydroxyjasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase] => a 12-oxojasmonyl-L-alpha-amino acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":56398,"RHEA_ID":59556,"compounds":"H2O + N,N'-diacetylchitobiono-1,5-lactone = H(+) + N,N'-diacetylchitobionate"}
{"X":56399,"RHEA_ID":58405,"compounds":"hexan-1-ol + NADP(+) => H(+) + hexanal + NADPH"}
{"X":56400,"RHEA_ID":58406,"compounds":"H(+) + hexanal + NADPH => hexan-1-ol + NADP(+)"}
{"X":56401,"RHEA_ID":57291,"compounds":"an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA + H2O <=> a guanosine in RNA + H(+) + lactate"}
{"X":56402,"RHEA_ID":60841,"compounds":"a 5'-end diphospho-adenosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] => a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + L-lysyl-[protein]"}
{"X":56403,"RHEA_ID":55438,"compounds":"H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + salviol => ferruginol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":56404,"RHEA_ID":62110,"compounds":"a monoacyl-sn-glycero-3-phosphoethanolamine + CoA => an acyl-CoA + sn-glycero-3-phosphoethanolamine"}
{"X":56405,"RHEA_ID":58411,"compounds":"NADP(+) + undecan-1-ol <=> H(+) + NADPH + undecanal"}
{"X":56406,"RHEA_ID":60845,"compounds":"a 5'-end diphospho-guanosine in mRNA + GTP + H(+) => a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + diphosphate"}
{"X":56407,"RHEA_ID":55072,"compounds":"2-oxobutanoate + H(+) = CO2 + propanal"}
{"X":56408,"RHEA_ID":56212,"DIRECTION":"UN","MASTER_ID":56212,"ec":"2.4.1.102","compounds":"O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP"}
{"X":56409,"RHEA_ID":59569,"DIRECTION":"LR","MASTER_ID":59568,"metacyc":"RXN-11222","compounds":"4-aminobutanoate + ATP + L-histidine => ADP + H(+) + L-homocarnosine + phosphate"}
{"X":56410,"RHEA_ID":59984,"DIRECTION":"UN","MASTER_ID":59984,"ec":"3.5.1.133","compounds":"an N(2)-acyl-L-glutamine + H2O = a carboxylate + L-glutamine"}
{"X":56411,"RHEA_ID":55077,"DIRECTION":"LR","MASTER_ID":55076,"metacyc":"RXN-7704","compounds":"4-methylsulfanyl-2-oxobutanoate + H(+) => 3-methylsulfanylpropanal + CO2"}
{"X":56412,"RHEA_ID":56216,"DIRECTION":"UN","MASTER_ID":56216,"ec":"2.4.1.102","compounds":"O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP"}
{"X":56413,"RHEA_ID":59572,"DIRECTION":"UN","MASTER_ID":59572,"ec":"3.4.13.5","compounds":"H2O + L-homocarnosine = 4-aminobutanoate + L-histidine"}
{"X":56414,"RHEA_ID":60856,"DIRECTION":"UN","MASTER_ID":60856,"ec":"2.1.1.56","compounds":"a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-homocysteine"}
{"X":56415,"RHEA_ID":55081,"compounds":"ADP-alpha-D-glucose + D-fructose => ADP + H(+) + sucrose"}
{"X":56416,"RHEA_ID":56220,"DIRECTION":"UN","MASTER_ID":56220,"ec":"2.4.1.146","compounds":"3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-seryl-[protein] + H(+) + UDP"}
{"X":56417,"RHEA_ID":62129,"compounds":"a 2'-deoxyribonucleoside 5'-phosphate + dGTP => a 2'-deoxyribonucleoside 5'-diphosphate + dGDP"}
{"X":56418,"RHEA_ID":58426,"compounds":"(E)-2-hexenal + H(+) + NADPH => (E)-hex-2-en-1-ol + NADP(+)"}
{"X":56419,"RHEA_ID":55085,"compounds":"(3R)-hydroxypentanoyl-CoA + H2O => (3R)-hydroxypentanoate + CoA + H(+)"}
{"X":56420,"RHEA_ID":57312,"DIRECTION":"UN","MASTER_ID":57312,"ec":"3.5.1.129","compounds":"H2O + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine = cytidine 5'-diphosphoramidate + H(+) + L-glutamate"}
{"X":56421,"RHEA_ID":55087,"compounds":"(3R)-hydroxypentanoyl-CoA + H2O <=> (3R)-hydroxypentanoate + CoA + H(+)"}
{"X":56422,"RHEA_ID":58429,"compounds":"(E,E)-2,4-hexadien-1-ol + NADP(+) => (E,E)-2,4-hexadienal + H(+) + NADPH"}
{"X":56423,"RHEA_ID":62134,"compounds":"a 2'-deoxyribonucleoside 5'-diphosphate + dTDP => a 2'-deoxyribonucleoside 5'-phosphate + dTTP"}
{"X":56424,"RHEA_ID":58432,"compounds":"(E)-4-oxonon-2-en-1-ol + NADP(+) = (E)-4-oxonon-2-enal + H(+) + NADPH"}
{"X":56425,"RHEA_ID":55091,"compounds":"24-methylene-24-dihydrolanosterol + S-adenosyl-L-methionine <=> (24Z)-ethylidenelanosterol + H(+) + S-adenosyl-L-homocysteine"}
{"X":56426,"RHEA_ID":58434,"compounds":"(E)-4-oxonon-2-enal + H(+) + NADPH => (E)-4-oxonon-2-en-1-ol + NADP(+)"}
{"X":56427,"RHEA_ID":55093,"DIRECTION":"LR","MASTER_ID":55092,"metacyc":"SUCROSE-SYNTHASE-RXN","compounds":"D-fructose + UDP-alpha-D-glucose => H(+) + sucrose + UDP"}
{"X":56428,"RHEA_ID":55094,"compounds":"H(+) + sucrose + UDP => D-fructose + UDP-alpha-D-glucose"}
{"X":56429,"RHEA_ID":56231,"compounds":"(9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphocholine <=> (9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA"}
{"X":56430,"RHEA_ID":58810,"compounds":"AMP + GMP + 2 H(+) => 2',3'-cGAMP + 2 H2O"}
{"X":56431,"RHEA_ID":55097,"compounds":"(3S)-hydroxypentanoyl-CoA + H2O => (3S)-hydroxypentanoate + CoA + H(+)"}
{"X":56432,"RHEA_ID":55098,"compounds":"(3S)-hydroxypentanoate + CoA + H(+) => (3S)-hydroxypentanoyl-CoA + H2O"}
{"X":56433,"RHEA_ID":56235,"compounds":"[(1->4)-alpha-D-galacturonosyl](n) + H2O <=> [(1->4)-alpha-D-galacturonosyl](n-2) + alpha-D-galacturonosyl-(1->4)-D-galacturonate"}
{"X":56434,"RHEA_ID":59591,"compounds":"ATP + beta-alanine + L-ornithine <=> ADP + beta-alanyl-L-ornithine + H(+) + phosphate"}
{"X":56435,"RHEA_ID":55101,"compounds":"3-oxopentanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxypentanoyl-[ACP] + NADP(+)"}
{"X":56436,"RHEA_ID":58444,"compounds":"N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N-methyl-L-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":56437,"RHEA_ID":56602,"compounds":"3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-threonyl-[EGF-like domain protein] + H(+) + UDP => 3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-threonyl-[EGF-like domain protein] + UDP-alpha-D-xylose"}
{"X":56438,"RHEA_ID":58818,"compounds":"ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate => ATP + L-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine"}
{"X":56439,"RHEA_ID":55105,"compounds":"3-oxoheptanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxyheptanoyl-[ACP] + NADP(+)"}
{"X":56440,"RHEA_ID":58448,"compounds":"N-terminal N-methyl-L-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N,N-dimethyl-L-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":56441,"RHEA_ID":56243,"compounds":"1,2-dioctanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] <=> 2-octanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl octanoate + apo--[retinol-binding protein]"}
{"X":56442,"RHEA_ID":58450,"compounds":"H(+) + N-terminal N,N-dimethyl-L-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N-methyl-L-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine"}
{"X":56443,"RHEA_ID":60885,"compounds":"a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine-phospho-ribonucleoside in mRNA + H2O => (N(7)-methyl 5'-triphospho-guanosine)-adenosine + a 5'-end phospho-ribonucleoside in mRNA + H(+)"}
{"X":56444,"RHEA_ID":58452,"compounds":"N-terminal N,N-dimethyl-L-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N,N,N-trimethyl-L-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":56445,"RHEA_ID":55111,"compounds":"3-oxononanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxynonanoyl-[ACP] + NADP(+)"}
{"X":56446,"RHEA_ID":56248,"compounds":"1,2-didodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] = 2-dodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl dodecanoate + apo--[retinol-binding protein]"}
{"X":56447,"RHEA_ID":55113,"compounds":"3-oxo-4-methylpentanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxy-4-methylpentanoyl-[ACP] + NADP(+)"}
{"X":56448,"RHEA_ID":55114,"compounds":"(3R)-hydroxy-4-methylpentanoyl-[ACP] + NADP(+) => 3-oxo-4-methylpentanoyl-[ACP] + H(+) + NADPH"}
{"X":56449,"RHEA_ID":62165,"DIRECTION":"LR","MASTER_ID":62164,"metacyc":"RXN-12544","compounds":"beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine + H2O => D-glucosamine + N-acetyl-D-glucosamine"}
{"X":56450,"RHEA_ID":58458,"compounds":"(R)-glycerate + D-mannose => (2R)-2-O-(alpha-D-mannosyl)-glycerate + H2O"}
{"X":56451,"RHEA_ID":55117,"compounds":"3-oxo-5-methylhexanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxy-5-methylhexanoyl-[ACP] + NADP(+)"}
{"X":56452,"RHEA_ID":55118,"compounds":"(3R)-hydroxy-5-methylhexanoyl-[ACP] + NADP(+) => 3-oxo-5-methylhexanoyl-[ACP] + H(+) + NADPH"}
{"X":56453,"RHEA_ID":55119,"compounds":"3-oxo-5-methylhexanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxy-5-methylhexanoyl-[ACP] + NADP(+)"}
{"X":56454,"RHEA_ID":60027,"compounds":"(R,R)-chrysanthemyl diphosphate + H2O <=> (R,R)-chrysanthemol + diphosphate"}
{"X":56455,"RHEA_ID":59624,"DIRECTION":"UN","MASTER_ID":59624,"ec":"3.4.13.4","compounds":"H2O + N(2)-(4-aminobutanoyl)-L-ornithine = 4-aminobutanoate + L-ornithine"}
{"X":56456,"RHEA_ID":60029,"compounds":"(2E)-geranyl diphosphate + H2O => 4-terpineol + diphosphate"}
{"X":56457,"RHEA_ID":56622,"compounds":"2,4,5-trichlorocyclohexa-2,5-dien-1-ol + chloride + H(+) => (3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + H2O"}
{"X":56458,"RHEA_ID":62174,"compounds":"an N-acylethanolamine + phosphate => an N-acylethanolamine phosphate + H2O"}
{"X":56459,"RHEA_ID":58467,"compounds":"a neolactoside nLc4Cer + UDP-N-acetyl-alpha-D-glucosamine <=> a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + H(+) + UDP"}
{"X":56460,"RHEA_ID":58468,"compounds":"2 2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 O2 = 2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate"}
{"X":56461,"RHEA_ID":60907,"compounds":"(9Z,12Z,15Z)-octadecatrienoate + O2 <=> 13-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate"}
{"X":56462,"RHEA_ID":59632,"compounds":"D-xylobiose + O2 = D-xylobiono-1,5-lactone + H2O2"}
{"X":56463,"RHEA_ID":58471,"compounds":"2 2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 O2 <=> 2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate"}
{"X":56464,"RHEA_ID":58472,"compounds":"2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + O2 = CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate"}
{"X":56465,"RHEA_ID":55131,"compounds":"(3R)-hydroxy-5-methylhexanoyl-[ACP] <=> (2E)-5-methylhexenoyl-[ACP] + H2O"}
{"X":56466,"RHEA_ID":58473,"compounds":"2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + O2 => CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate"}
{"X":56467,"RHEA_ID":60041,"DIRECTION":"LR","MASTER_ID":60040,"metacyc":"RXN-19539","compounds":"H2O + N(2)-[(2E)-3-methylhex-2-enoyl]-L-glutaminate => (2E)-3-methylhex-2-enoate + L-glutamine"}
{"X":56468,"RHEA_ID":61322,"compounds":"H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + parthenolide => (+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":56469,"RHEA_ID":62681,"DIRECTION":"LR","MASTER_ID":62680,"metacyc":"RXN-16922","compounds":"YWA1 => H(+) + H2O + norrubrofusarin"}
{"X":56470,"RHEA_ID":58477,"DIRECTION":"LR","MASTER_ID":58476,"metacyc":"RXN-15380","compounds":"an acyl-CoA + sn-glycerol 3-phosphocholine => a 1-acyl-sn-glycero-3-phosphocholine + CoA"}
{"X":56471,"RHEA_ID":58479,"compounds":"an acyl-CoA + sn-glycerol 3-phosphocholine <=> a 1-acyl-sn-glycero-3-phosphocholine + CoA"}
{"X":56472,"RHEA_ID":58480,"compounds":"a cytidine in mRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in mRNA + CoA + H(+) + phosphate"}
{"X":56473,"RHEA_ID":56275,"compounds":"4 [Fe(III)cytochrome cL] + H2O + methanol <=> 4 [Fe(II)cytochrome cL] + formate + 5 H(+)"}
{"X":56474,"RHEA_ID":58481,"compounds":"a cytidine in mRNA + acetyl-CoA + ATP + H2O => ADP + an N(4)-acetylcytidine in mRNA + CoA + H(+) + phosphate"}
{"X":56475,"RHEA_ID":58854,"compounds":"(6E)-8-oxogeranial + H(+) + NADH => (6E)-8-oxogeraniol + NAD(+)"}
{"X":56476,"RHEA_ID":58484,"compounds":"H2O + N-(acetyl)-sphing-4-enine = acetate + sphing-4-enine"}
{"X":56477,"RHEA_ID":55143,"compounds":"D-alanyl-5'-AMP + holo-[D-alanyl-carrier protein] <=> AMP + D-alanyl-[D-alanyl-carrier protein] + H(+)"}
{"X":56478,"RHEA_ID":55514,"compounds":"11-hydroxycucurbitadienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":56479,"RHEA_ID":58487,"compounds":"H2O + N-(acetyl)-sphing-4-enine <=> acetate + sphing-4-enine"}
{"X":56480,"RHEA_ID":62194,"compounds":"H(+) + H2O + labd-13Z-ene-9,15,16-triol + oxidized [NADPH--hemoprotein reductase] => O2 + peregrinol + reduced [NADPH--hemoprotein reductase]"}
{"X":56481,"RHEA_ID":56283,"compounds":"3'-L-prolyl-AMP + holo-[peptidyl-carrier protein] <=> AMP + L-prolyl-[peptidyl-carrier protein]"}
{"X":56482,"RHEA_ID":55148,"DIRECTION":"UN","MASTER_ID":55148,"ec":"1.3.1.113","compounds":"a [(3S)-4-alkanoyl-5-oxooxolan-3-yl]methyl phosphate + NADP(+) = a (4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate + H(+) + NADPH"}
{"X":56483,"RHEA_ID":58491,"compounds":"4-(trimethylamino)butanoate + H(+) + NADH + O2 <=> H2O + NAD(+) + succinate semialdehyde + trimethylamine"}
{"X":56484,"RHEA_ID":58864,"compounds":"4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 = 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":56485,"RHEA_ID":58493,"DIRECTION":"LR","MASTER_ID":58492,"ecocyc":"ABC-10-RXN","metacyc":"ABC-10-RXN","compounds":"ATP + Fe(III)-enterobactin(out) + H2O => ADP + Fe(III)-enterobactin(in) + H(+) + phosphate"}
{"X":56486,"RHEA_ID":55152,"DIRECTION":"UN","MASTER_ID":55152,"ec":"1.3.8.14","compounds":"H(+) + L-prolyl-[peptidyl-carrier protein] + 2 oxidized [electron-transfer flavoprotein] = (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 reduced [electron-transfer flavoprotein]"}
{"X":56487,"RHEA_ID":55153,"DIRECTION":"LR","MASTER_ID":55152,"metacyc":"RXN-19070","compounds":"H(+) + L-prolyl-[peptidyl-carrier protein] + 2 oxidized [electron-transfer flavoprotein] => (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 reduced [electron-transfer flavoprotein]"}
{"X":56488,"RHEA_ID":55154,"compounds":"(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 reduced [electron-transfer flavoprotein] => H(+) + L-prolyl-[peptidyl-carrier protein] + 2 oxidized [electron-transfer flavoprotein]"}
{"X":56489,"RHEA_ID":60935,"compounds":"(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 17-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":56490,"RHEA_ID":55526,"compounds":"3,4-dihydroxyphenylacetaldehyde + CO2 + H2O2 + NH4(+) => H(+) + H2O + L-dopa + O2"}
{"X":56491,"RHEA_ID":62206,"compounds":"2 [Fe(II)cytochrome c] + 2 H(+) + propanal => 1-propanol + 2 [Fe(III)cytochrome c]"}
{"X":56492,"RHEA_ID":58500,"compounds":"betaine + H(+) + NADH + O2 = glyoxylate + H2O + NAD(+) + trimethylamine"}
{"X":56493,"RHEA_ID":59663,"compounds":"D-cellotetraose + O2 <=> D-cellotetraono-1,5-lactone + H2O2"}
{"X":56494,"RHEA_ID":55530,"compounds":"(4-hydroxyphenyl)acetaldehyde + CO2 + H2O2 + NH4(+) => H(+) + H2O + L-tyrosine + O2"}
{"X":56495,"RHEA_ID":58503,"compounds":"betaine + H(+) + NADH + O2 <=> glyoxylate + H2O + NAD(+) + trimethylamine"}
{"X":56496,"RHEA_ID":55162,"compounds":"coenzyme M-coenzyme B heterodisulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => coenzyme B + coenzyme M + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":56497,"RHEA_ID":56299,"compounds":"3-mercaptopyruvate + L-cysteinyl-[protein] <=> pyruvate + S-sulfanyl-L-cysteinyl-[protein]"}
{"X":56498,"RHEA_ID":55534,"compounds":"2-phenylacetaldehyde + CO2 + H2O2 + NH4(+) => H(+) + H2O + L-phenylalanine + O2"}
{"X":56499,"RHEA_ID":60072,"compounds":"4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADH + O2 = 4beta-hydroxymethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + H2O + NAD(+)"}
{"X":56500,"RHEA_ID":55536,"compounds":"an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose = a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+)"}
{"X":56501,"RHEA_ID":56303,"compounds":"[thioredoxin]-dithiol + S-sulfanyl-L-cysteinyl-[protein] <=> [thioredoxin]-disulfide + H(+) + hydrogen sulfide + L-cysteinyl-[protein]"}
{"X":56502,"RHEA_ID":55168,"compounds":"[TtuB sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) = [TtuB sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate"}
{"X":56503,"RHEA_ID":62218,"compounds":"H(+) + NADPH + phyllostine => isoepoxydon + NADP(+)"}
{"X":56504,"RHEA_ID":55540,"DIRECTION":"UN","MASTER_ID":55540,"ec":"1.18.6.2","compounds":"40 ATP + 40 H2O + N2 + 12 reduced [2Fe-2S]-[ferredoxin] = 40 ADP + 26 H(+) + 3 H2 + 2 NH4(+) + 12 oxidized [2Fe-2S]-[ferredoxin] + 40 phosphate"}
{"X":56505,"RHEA_ID":62729,"compounds":"(+)-malbrancheamide B + bromide + FAD + 2 H(+) => (+)-malbrancheamide D + FADH2"}
{"X":56506,"RHEA_ID":55542,"compounds":"40 ADP + 26 H(+) + 3 H2 + 2 NH4(+) + 12 oxidized [2Fe-2S]-[ferredoxin] + 40 phosphate => 40 ATP + 40 H2O + N2 + 12 reduced [2Fe-2S]-[ferredoxin]"}
{"X":56507,"RHEA_ID":58515,"compounds":"1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH <=> 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)"}
{"X":56508,"RHEA_ID":59678,"compounds":"D-maltotetraono-1,5-lactone + H2O2 => D-maltotetraose + O2"}
{"X":56509,"RHEA_ID":56674,"DIRECTION":"RL","MASTER_ID":56672,"metacyc":"RXN-11467","compounds":"(E)-4-coumaroyl-CoA + H(+) + NADPH => dihydro-4-coumaroyl-CoA + NADP(+)"}
{"X":56510,"RHEA_ID":55176,"compounds":"2-oxoglutarate + butanoyl-CoA + O2 = 2-hydroxybutanoyl-CoA + CO2 + succinate"}
{"X":56511,"RHEA_ID":56676,"DIRECTION":"UN","MASTER_ID":56676,"ec":"1.3.1.117","compounds":"dihydroferuloyl-CoA + NADP(+) = (E)-feruloyl-CoA + H(+) + NADPH"}
{"X":56512,"RHEA_ID":59682,"compounds":"D-maltopentaono-1,5-lactone + H2O2 => D-maltopentaose + O2"}
{"X":56513,"RHEA_ID":55179,"compounds":"2-oxoglutarate + butanoyl-CoA + O2 <=> 2-hydroxybutanoyl-CoA + CO2 + succinate"}
{"X":56514,"RHEA_ID":59684,"compounds":"D-maltohexaose + O2 = D-maltohexaono-1,5-lactone + H2O2"}
{"X":56515,"RHEA_ID":62230,"compounds":"AH2 + patulin => (E)-ascladiol + A"}
{"X":56516,"RHEA_ID":58524,"compounds":"15alpha-stemmadenine intermediate I + H2O + NADPH = (16S)-deshydroxymethyl-stemmadenine + formate + NADP(+)"}
{"X":56517,"RHEA_ID":55183,"compounds":"2-oxoglutarate + 3-methylnonanoyl-CoA + O2 <=> 2-hydroxy-3-methylnonanoyl-CoA + CO2 + succinate"}
{"X":56518,"RHEA_ID":59688,"compounds":"D-maltoheptaose + O2 = D-maltoheptaono-1,5-lactone + H2O2"}
{"X":56519,"RHEA_ID":62234,"compounds":"a thymidine dimer in DNA => a thymidine(6-4)thymidine in DNA"}
{"X":56520,"RHEA_ID":58528,"compounds":"15alpha-stemmadenine intermediate I + H2O + NADPH = (16R)-deshydroxymethyl-stemmadenine + formate + NADP(+)"}
{"X":56521,"RHEA_ID":55187,"compounds":"2-oxoglutarate + 3-methylundecanoyl-CoA + O2 <=> 2-hydroxy-3-methylundecanoyl-CoA + CO2 + succinate"}
{"X":56522,"RHEA_ID":55188,"compounds":"5-methyluridine(54) in tRNA + ATP + hydrogen sulfide = 5-methyl-2-thiouridine(54) in tRNA + AMP + diphosphate"}
{"X":56523,"RHEA_ID":62238,"compounds":"a cytidine dimer in DNA + H(+) => a cytidine(6-4)cytidine in DNA"}
{"X":56524,"RHEA_ID":55191,"compounds":"5-methyluridine(54) in tRNA + ATP + hydrogen sulfide <=> 5-methyl-2-thiouridine(54) in tRNA + AMP + diphosphate"}
{"X":56525,"RHEA_ID":58914,"compounds":"ADP + H(+) + iron(III) dicitrate(in) + phosphate => ATP + H2O + iron(III) dicitrate(out)"}
{"X":56526,"RHEA_ID":59697,"compounds":"D-cellotetraono-1,5-lactone + H2O => D-cellotetraonate + H(+)"}
{"X":56527,"RHEA_ID":58536,"compounds":"glycine + hexadecanoyl-CoA = CoA + H(+) + N-hexadecanoylglycine"}
{"X":56528,"RHEA_ID":55195,"compounds":"2-oxoglutarate + 3-methyldodecanoyl-CoA + O2 <=> 2-hydroxy-3-methyldodecanoyl-CoA + CO2 + succinate"}
{"X":56529,"RHEA_ID":55196,"compounds":"2-hydroxyoctadecanoyl-CoA = formyl-CoA + heptadecanal"}
{"X":56530,"RHEA_ID":60981,"compounds":"12-hydroxydodecanoate + NAD(+) => 12-oxododecanoate + H(+) + NADH"}
{"X":56531,"RHEA_ID":58540,"compounds":"2 L-ascorbate + N-dodecanoylglycine + O2 = H2O + 2 monodehydro-L-ascorbate radical + N-dodecanoyl-(2S)-hydroxyglycine"}
{"X":56532,"RHEA_ID":58541,"compounds":"2 L-ascorbate + N-dodecanoylglycine + O2 => H2O + 2 monodehydro-L-ascorbate radical + N-dodecanoyl-(2S)-hydroxyglycine"}
{"X":56533,"RHEA_ID":55200,"DIRECTION":"UN","MASTER_ID":55200,"ec":"2.5.1.147","compounds":"5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine = 2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H(+) + L-methionine"}
{"X":56534,"RHEA_ID":56700,"DIRECTION":"UN","MASTER_ID":56700,"ec":"1.14.20.11","compounds":"(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 = 3-[(Z)-2-isocyanoethenyl]-1H-indole + 2 CO2 + H2O + succinate"}
{"X":56535,"RHEA_ID":58544,"compounds":"2 L-ascorbate + N-tetradecanoylglycine + O2 = H2O + 2 monodehydro-L-ascorbate radical + N-tetradecanoyl-(2S)-hydroxyglycine"}
{"X":56536,"RHEA_ID":55203,"compounds":"5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine <=> 2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H(+) + L-methionine"}
{"X":56537,"RHEA_ID":58546,"compounds":"H2O + 2 monodehydro-L-ascorbate radical + N-tetradecanoyl-(2S)-hydroxyglycine => 2 L-ascorbate + N-tetradecanoylglycine + O2"}
{"X":56538,"RHEA_ID":57435,"compounds":"3-methoxycatechol + O2 + reduced [NADH--hemoprotein reductase] <=> 1,2,3-trihydroxybenzene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]"}
{"X":56539,"RHEA_ID":57436,"compounds":"guaethol + O2 + reduced [NADH--hemoprotein reductase] = acetaldehyde + catechol + H(+) + H2O + oxidized [NADH--hemoprotein reductase]"}
{"X":56540,"RHEA_ID":58548,"compounds":"2 L-ascorbate + N-(9Z,12Z,15Z)-octadecatrienoylglycine + O2 = H2O + 2 monodehydro-L-ascorbate radical + N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine"}
{"X":56541,"RHEA_ID":57818,"compounds":"2-deoxy-D-ribose 5-phosphate + guanine => dGMP + H2O"}
{"X":56542,"RHEA_ID":62258,"compounds":"Cd(2+)(in) + 2 hydrogencarbonate(in) => Cd(2+)(out) + 2 hydrogencarbonate(out)"}
{"X":56543,"RHEA_ID":58551,"compounds":"2 L-ascorbate + N-(9Z,12Z,15Z)-octadecatrienoylglycine + O2 <=> H2O + 2 monodehydro-L-ascorbate radical + N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine"}
{"X":56544,"RHEA_ID":59715,"compounds":"D-maltotetraono-1,5-lactone + H2O <=> D-maltotetraonate + H(+)"}
{"X":56545,"RHEA_ID":55212,"compounds":"(2R)-hydroxyhexadecanoyl-CoA = formyl-CoA + pentadecanal"}
{"X":56546,"RHEA_ID":61021,"compounds":"acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA => 5'-deoxyadenosine + carboxymethyluridine(34) in tRNA + CoA + 2 H(+) + L-methionine"}
{"X":56547,"RHEA_ID":58556,"compounds":"15alpha-stemmadenine intermediate II + H2O = (16S)-deshydroxymethyl-stemmadenine + formate"}
{"X":56548,"RHEA_ID":61023,"compounds":"acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA <=> 5'-deoxyadenosine + carboxymethyluridine(34) in tRNA + CoA + 2 H(+) + L-methionine"}
{"X":56549,"RHEA_ID":58557,"compounds":"15alpha-stemmadenine intermediate II + H2O => (16S)-deshydroxymethyl-stemmadenine + formate"}
{"X":56550,"RHEA_ID":56716,"DIRECTION":"UN","MASTER_ID":56716,"ec":"3.1.6.20","compounds":"H2O + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein] = H(+) + S-disulfanyl-L-cysteinyl-[SoxY protein] + sulfate"}
{"X":56551,"RHEA_ID":62268,"compounds":"(R)-2-hydroxy-3-methylbutyrate + NADP(+) = 3-methyl-2-oxobutanoate + H(+) + NADPH"}
{"X":56552,"RHEA_ID":58561,"compounds":"15alpha-stemmadenine intermediate II + NADP(+) => 15alpha-stemmadenine intermediate I + NADPH"}
{"X":56553,"RHEA_ID":60128,"compounds":"17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + H(+) + phosphate"}
{"X":56554,"RHEA_ID":59725,"compounds":"D-maltoheptaono-1,5-lactone + H2O => D-maltoheptaonate + H(+)"}
{"X":56555,"RHEA_ID":61411,"compounds":"ATP + N(6)-(D-erythrulosyl)-L-lysine <=> ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysine"}
{"X":56556,"RHEA_ID":59342,"compounds":"1'-hydroxy-demethylspheroidene + AH2 => 1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene + A"}
{"X":56557,"RHEA_ID":58566,"DIRECTION":"RL","MASTER_ID":58564,"metacyc":"RXN-19983","compounds":"15alpha-stemmadenine intermediate II + 2 H(+) + NADPH => 15alpha-stemmadenine + NADP(+)"}
{"X":56558,"RHEA_ID":59730,"DIRECTION":"RL","MASTER_ID":59728,"metacyc":"RXN-16391","compounds":"(2S)-ethylmalonyl-CoA => (2R)-ethylmalonyl-CoA"}
{"X":56559,"RHEA_ID":61043,"compounds":"(+)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":56560,"RHEA_ID":55228,"compounds":"4beta-hydroxymethyl-4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":56561,"RHEA_ID":56365,"DIRECTION":"LR","MASTER_ID":56364,"metacyc":"RXN-16479","compounds":"13-dihydrocarminomycin + H(+) + NADPH + O2 => carminomycin + 2 H2O + NADP(+)"}
{"X":56562,"RHEA_ID":59734,"compounds":"AMP + 2 H(+) + N(6)-biotinyl-L-lysyl-[protein] => biotinyl-5'-AMP + L-lysyl-[protein]"}
{"X":56563,"RHEA_ID":58573,"DIRECTION":"LR","MASTER_ID":58572,"metacyc":"RXN-19972","compounds":"O-acetyl-15alpha-stemmadenine + O2 => H2O2 + precondylocarpine acetate"}
{"X":56564,"RHEA_ID":59736,"compounds":"L-cysteinyl-[protein] + tetradecanoyl-CoA = CoA + S-tetradecanoyl-L-cysteinyl-[protein]"}
{"X":56565,"RHEA_ID":61049,"compounds":"lochnericine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + horhammericine + oxidized [NADPH--hemoprotein reductase]"}
{"X":56566,"RHEA_ID":58955,"compounds":"(20S)-protopanaxatriol + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rh1 + H(+) + UDP"}
{"X":56567,"RHEA_ID":60142,"compounds":"3-oxotetradecanoyl-CoA + CO2 + CoA => dodecanoyl-CoA + H(+) + malonyl-CoA"}
{"X":56568,"RHEA_ID":55236,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H2O = (9Z)-octadecenoate + 1-octadecanoyl-2-hydroxy-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H(+)"}
{"X":56569,"RHEA_ID":56373,"DIRECTION":"LR","MASTER_ID":56372,"metacyc":"RXN-19112","compounds":"3,4-dihydroxybenzoate + bromide + 2 H(+) + NADPH + O2 => 3-bromo-4,5-dihydroxybenzoate + 2 H2O + NADP(+)"}
{"X":56570,"RHEA_ID":62292,"compounds":"(8aS)-3-{[2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl]methyl}-1H,2H,6H,7H,8H,8aH-pyrrolo[1,2-a]pyrazin-1-one + A + H(+) = 1-hydroxy-3-{[2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl]methyl}-6H,7H,8H-5lambda5-pyrrolo[1,2-a]pyrazine + AH2"}
{"X":56571,"RHEA_ID":55239,"compounds":"1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H2O <=> (9Z)-octadecenoate + 1-octadecanoyl-2-hydroxy-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H(+)"}
{"X":56572,"RHEA_ID":56739,"compounds":"H2O + O2 + retinal <=> H(+) + H2O2 + retinoate"}
{"X":56573,"RHEA_ID":60148,"compounds":"(L-glutamyl)n-L-gamma-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate = (L-glutamyl)n+1-L-gamma-glutamyl-L-glutamyl-[protein] + ADP + H(+) + phosphate"}
{"X":56574,"RHEA_ID":60617,"compounds":"N-dodecanoyl-heptadecasphing-4-enine-1-phosphoethanolamine => ethanolamine + N-dodecanoyl-heptadecasphing-4-enine-1,3-cyclic phosphate"}
{"X":56575,"RHEA_ID":55243,"compounds":"1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H2O <=> (9Z)-octadecenoate + 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H(+)"}
{"X":56576,"RHEA_ID":55244,"compounds":"4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}
{"X":56577,"RHEA_ID":57854,"compounds":"2-deoxy-D-ribose 5-phosphate + a pyrimidine nucleobase => a pyrimidine 2'-deoxyribonucleoside 5'-phosphate + H2O"}
{"X":56578,"RHEA_ID":59750,"compounds":"CoA + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-cysteinyl-[protein] => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + L-cysteinyl-[protein]"}
{"X":56579,"RHEA_ID":62298,"compounds":"(+)-malbrancheamide + 2 FADH2 => (+)-premalbrancheamide + 2 chloride + 2 FAD + 4 H(+)"}
{"X":56580,"RHEA_ID":55248,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":56581,"RHEA_ID":56748,"DIRECTION":"UN","MASTER_ID":56748,"ec":"1.14.14.80","compounds":"an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":56582,"RHEA_ID":59754,"compounds":"CoA + H(+) + N(6)-tetradecanoyl-L-lysyl-[protein] => L-lysyl-[protein] + tetradecanoyl-CoA"}
{"X":56583,"RHEA_ID":55251,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine <=> 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":56584,"RHEA_ID":55252,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine = 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":56585,"RHEA_ID":59765,"compounds":"L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + octadecanoyl-CoA => CoA + H(+) + N(6)-octadecanoyl-L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein]"}
{"X":56586,"RHEA_ID":59766,"compounds":"CoA + H(+) + N(6)-octadecanoyl-L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein] => L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + octadecanoyl-CoA"}
{"X":56587,"RHEA_ID":62307,"compounds":"1-hydroxy-3-{[2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine <=> (+)-premalbrancheamide"}
{"X":56588,"RHEA_ID":55256,"compounds":"1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":56589,"RHEA_ID":62311,"compounds":"(+)-premalbrancheamide + chloride + FAD + 2 H(+) <=> (+)-malbrancheamide B + FADH2"}
{"X":56590,"RHEA_ID":59770,"compounds":"CoA + H(+) + N(6)-hexadecanoyl-L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein] => hexadecanoyl-CoA + L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein]"}
{"X":56591,"RHEA_ID":55259,"compounds":"1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":56592,"RHEA_ID":59780,"compounds":"L-histidine + S-adenosyl-L-methionine = (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine"}
{"X":56593,"RHEA_ID":59781,"DIRECTION":"LR","MASTER_ID":59780,"metacyc":"RXN-19827","compounds":"L-histidine + S-adenosyl-L-methionine => (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine"}
{"X":56594,"RHEA_ID":58607,"compounds":"FAD + 2 H(+) + NADH + O2 <=> FADH2-C4alpha-hydroperoxide + NAD(+)"}
{"X":56595,"RHEA_ID":55263,"compounds":"2 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":56596,"RHEA_ID":55264,"compounds":"1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine = di-(9Z,12Z)-octadecadienoylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine"}
{"X":56597,"RHEA_ID":58987,"compounds":"acrolein + H2O + O2 <=> acrylate + H(+) + H2O2"}
{"X":56598,"RHEA_ID":60184,"compounds":"ATP + D-glucose(out) + H2O = ADP + D-glucose(in) + H(+) + phosphate"}
{"X":56599,"RHEA_ID":59384,"compounds":"2-oxoglutarate + 4-amino-L-phenylalanine = 3-(4-aminophenyl)pyruvate + L-glutamate"}
{"X":56600,"RHEA_ID":58614,"compounds":"H2O + 2 monodehydro-L-ascorbate radical + N-octanoyl-(2S)-hydroxyglycine => 2 L-ascorbate + N-octanoylglycine + O2"}
{"X":56601,"RHEA_ID":55269,"compounds":"(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate => (R)-glycerate + alpha-D-glucose 1-phosphate"}
{"X":56602,"RHEA_ID":58992,"compounds":"cinnamaldehyde + H2O + O2 = cinnamate + H(+) + H2O2"}
{"X":56603,"RHEA_ID":58617,"compounds":"N-octanoyl-(2S)-hydroxyglycine => glyoxylate + octanamide"}
{"X":56604,"RHEA_ID":58618,"compounds":"glyoxylate + octanamide => N-octanoyl-(2S)-hydroxyglycine"}
{"X":56605,"RHEA_ID":58619,"compounds":"N-octanoyl-(2S)-hydroxyglycine <=> glyoxylate + octanamide"}
{"X":56606,"RHEA_ID":58620,"compounds":"N-decanoyl-(2S)-hydroxyglycine = decanamide + glyoxylate"}
{"X":56607,"RHEA_ID":55275,"compounds":"11-cis-retinol + tetradecanoyl-CoA <=> 11-cis-retinyl tetradecanoate + CoA"}
{"X":56608,"RHEA_ID":58622,"compounds":"decanamide + glyoxylate => N-decanoyl-(2S)-hydroxyglycine"}
{"X":56609,"RHEA_ID":61101,"DIRECTION":"LR","MASTER_ID":61100,"metacyc":"RXN-7921","compounds":"(S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase] => (2S)-dihydrotricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":56610,"RHEA_ID":56414,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-ditetradecanoyl-sn-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine"}
{"X":56611,"RHEA_ID":55279,"compounds":"9-cis-retinol + tetradecanoyl-CoA <=> 9-cis-retinyl tetradecanoate + CoA"}
{"X":56612,"RHEA_ID":55280,"compounds":"13-cis-retinol + tetradecanoyl-CoA = 13-cis-retinyl tetradecanoate + CoA"}
{"X":56613,"RHEA_ID":58627,"compounds":"N-dodecanoyl-(2S)-hydroxyglycine <=> dodecanamide + glyoxylate"}
{"X":56614,"RHEA_ID":58628,"compounds":"FADH2-C4alpha-hydroperoxide + H(+) + NADPH + rifamycin SV = FADH2 + H2O + NADP(+) + rifamycin SV hemiaminal"}
{"X":56615,"RHEA_ID":55283,"compounds":"13-cis-retinol + tetradecanoyl-CoA <=> 13-cis-retinyl tetradecanoate + CoA"}
{"X":56616,"RHEA_ID":56420,"compounds":"apo-[D-alanyl-carrier protein] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[D-alanyl-carrier protein]"}
{"X":56617,"RHEA_ID":56421,"compounds":"apo-[D-alanyl-carrier protein] + CoA => adenosine 3',5'-bisphosphate + H(+) + holo-[D-alanyl-carrier protein]"}
{"X":56618,"RHEA_ID":56422,"compounds":"adenosine 3',5'-bisphosphate + H(+) + holo-[D-alanyl-carrier protein] => apo-[D-alanyl-carrier protein] + CoA"}
{"X":56619,"RHEA_ID":55287,"compounds":"all-trans-retinol + tetradecanoyl-CoA <=> all-trans-retinyl tetradecanoate + CoA"}
{"X":56620,"RHEA_ID":58634,"compounds":"glyoxylate + tetradecamide => N-tetradecanoyl-(2S)-hydroxyglycine"}
{"X":56621,"RHEA_ID":59809,"compounds":"L-tyrosine => D-tyrosine"}
{"X":56622,"RHEA_ID":60209,"DIRECTION":"LR","MASTER_ID":60208,"metacyc":"RXN-20594","compounds":"3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 O2 => 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate"}
{"X":56623,"RHEA_ID":55291,"compounds":"tetradecan-1-ol + tetradecanoyl-CoA <=> CoA + tetradecanyl tetradecanoate"}
{"X":56624,"RHEA_ID":55292,"DIRECTION":"UN","MASTER_ID":55292,"ec":"2.1.1.257","compounds":"pseudouridine(54) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylpseudouridine(54) in tRNA + S-adenosyl-L-homocysteine"}
{"X":56625,"RHEA_ID":57531,"compounds":"5'-end ribonucleotide-RNA + a ribonucleoside 5'-triphosphate + ATP + H2O <=> 5'-phospho-ribonucleosidyl-ribonucleotide-RNA + AMP + 2 diphosphate + H(+)"}
{"X":56626,"RHEA_ID":62346,"compounds":"diphosphate + notoamide S => 6-hydroxydeoxybrevianamide E + dimethylallyl diphosphate"}
{"X":56627,"RHEA_ID":59815,"compounds":"hexadecanoyl-CoA + N-terminal glycyl-[protein] <=> CoA + H(+) + N-terminal N(6)-hexadecanoylglycyl-[protein]"}
{"X":56628,"RHEA_ID":58642,"compounds":"a 5'-(5'-bisphosphomethyl)-ribonucleoside-RNA + 2 S-adenosyl-L-homocysteine => a 5'-(5'-phospho)-ribonucleoside-RNA + 2 S-adenosyl-L-methionine"}
{"X":56629,"RHEA_ID":58643,"compounds":"a 5'-(5'-phospho)-ribonucleoside-RNA + 2 S-adenosyl-L-methionine <=> a 5'-(5'-bisphosphomethyl)-ribonucleoside-RNA + 2 S-adenosyl-L-homocysteine"}
{"X":56630,"RHEA_ID":55298,"compounds":"13-cis-retinyl hexadecanoate + CoA => 13-cis-retinol + hexadecanoyl-CoA"}
{"X":56631,"RHEA_ID":58645,"compounds":"N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine => (9Z,12Z,15Z)-octadecatrienamide + glyoxylate"}
{"X":56632,"RHEA_ID":58646,"compounds":"(9Z,12Z,15Z)-octadecatrienamide + glyoxylate => N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine"}
{"X":56633,"RHEA_ID":58647,"compounds":"N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine <=> (9Z,12Z,15Z)-octadecatrienamide + glyoxylate"}
{"X":56634,"RHEA_ID":57540,"compounds":"5'-NTP-ribonucleotide-RNA + H2O = 5'-phospho-ribonucleosidyl-ribonucleotide-RNA + diphosphate + H(+)"}
{"X":56635,"RHEA_ID":59831,"compounds":"H2O + S-inosyl-L-homocysteine <=> inosine + L-homocysteine"}
{"X":56636,"RHEA_ID":55304,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA"}
{"X":56637,"RHEA_ID":58651,"compounds":"rifamycin SV hemiaminal <=> H(+) + rifamycin SV ortho-naphthoquinone carboxamide"}
{"X":56638,"RHEA_ID":55306,"compounds":"1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate"}
{"X":56639,"RHEA_ID":55307,"compounds":"(9Z,12Z)-octadecadienoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate <=> 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA"}
{"X":56640,"RHEA_ID":55308,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":56641,"RHEA_ID":57170,"compounds":"2-oxoglutarate + FADH2 => (R)-2-hydroxyglutarate + FAD + H(+)"}
{"X":56642,"RHEA_ID":61985,"compounds":"H(+) + NADH + ubiquinone-10 => NAD(+) + ubiquinol-10"}
{"X":56643,"RHEA_ID":58657,"compounds":"a 5'-(5'-phospho)-ribonucleoside-RNA + S-adenosyl-L-methionine => a 5'-(5'-phosphomethyl)-ribonucleoside-RNA + S-adenosyl-L-homocysteine"}
{"X":56644,"RHEA_ID":55312,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA"}
{"X":56645,"RHEA_ID":59840,"compounds":"(6S)-5,6,7,8-tetrahydrofolate + syringate = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-O-methylgallate"}
{"X":56646,"RHEA_ID":60692,"compounds":"(E)-non-2-enal + H2O + NADP(+) = (E)-non-2-enoate + 2 H(+) + NADPH"}
{"X":56647,"RHEA_ID":58661,"compounds":"a 5'-(5'-phosphomethyl)-ribonucleoside-RNA + S-adenosyl-L-methionine => a 5'-(5'-bisphosphomethyl)-ribonucleoside-RNA + S-adenosyl-L-homocysteine"}
{"X":56648,"RHEA_ID":56451,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)"}
{"X":56649,"RHEA_ID":58663,"compounds":"a 5'-(5'-phosphomethyl)-ribonucleoside-RNA + S-adenosyl-L-methionine <=> a 5'-(5'-bisphosphomethyl)-ribonucleoside-RNA + S-adenosyl-L-homocysteine"}
{"X":56650,"RHEA_ID":62372,"DIRECTION":"UN","MASTER_ID":62372,"ec":"2.1.1.74","compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + uridine(54) in tRNA = (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NADP(+)"}
{"X":56651,"RHEA_ID":58665,"DIRECTION":"LR","MASTER_ID":58664,"ecocyc":"RXN0-7319","metacyc":"RXN0-7319","compounds":"(S)-2-hydroxyglutarate + a quinone => 2-oxoglutarate + a quinol"}
{"X":56652,"RHEA_ID":55320,"compounds":"1,2-diheptanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] = 2-heptanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl heptanoate + apo--[retinol-binding protein]"}
{"X":56653,"RHEA_ID":59849,"compounds":"(2R,3S)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH => (S)-tetrahydrodehydrodiconiferyl alcohol + NADP(+)"}
{"X":56654,"RHEA_ID":62374,"compounds":"(6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NADP(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + uridine(54) in tRNA"}
{"X":56655,"RHEA_ID":58669,"compounds":"3-deoxyfructose + NADP(+) => 3-deoxyglucosone + H(+) + NADPH"}
{"X":56656,"RHEA_ID":59852,"compounds":"(2S,3R)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH = (R)-tetrahydrodehydrodiconiferyl alcohol + NADP(+)"}
{"X":56657,"RHEA_ID":58671,"compounds":"3-deoxyfructose + NADP(+) <=> 3-deoxyglucosone + H(+) + NADPH"}
{"X":56658,"RHEA_ID":57935,"compounds":"beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + NH4(+) <=> beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + H(+) + phosphate"}
{"X":56659,"RHEA_ID":56463,"compounds":"H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine"}
{"X":56660,"RHEA_ID":55332,"DIRECTION":"UN","MASTER_ID":55332,"ec":"2.1.1.42","compounds":"a 3'-hydroxyflavone + S-adenosyl-L-methionine = a 3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine"}
{"X":56661,"RHEA_ID":56465,"compounds":"1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H2O => 1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}
{"X":56662,"RHEA_ID":55333,"DIRECTION":"LR","MASTER_ID":55332,"metacyc":"RXN-13955","compounds":"a 3'-hydroxyflavone + S-adenosyl-L-methionine => a 3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine"}
{"X":56663,"RHEA_ID":59456,"compounds":"NADP(+) + tetradecan-1-ol = H(+) + NADPH + tetradecanal"}
{"X":56664,"RHEA_ID":58678,"compounds":"H2O + NADP(+) + rifamycin SV para-naphthoquinone carboxamide => NADPH + O2 + rifamycin SV"}
{"X":56665,"RHEA_ID":58679,"compounds":"NADPH + O2 + rifamycin SV <=> H2O + NADP(+) + rifamycin SV para-naphthoquinone carboxamide"}
{"X":56666,"RHEA_ID":58680,"compounds":"A + FADH2 = AH2 + FAD + H(+)"}
{"X":56667,"RHEA_ID":59863,"compounds":"3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-[N-acetyl-beta-D-glucosaminyl-(1->6)-N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP"}
{"X":56668,"RHEA_ID":57573,"DIRECTION":"LR","MASTER_ID":57572,"metacyc":"RXN-15237","compounds":"7-deoxyloganetic aldehyde + O2 + reduced [NADPH--hemoprotein reductase] => 7-deoxyloganetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":56669,"RHEA_ID":57575,"compounds":"7-deoxyloganetic aldehyde + O2 + reduced [NADPH--hemoprotein reductase] <=> 7-deoxyloganetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":56670,"RHEA_ID":59865,"compounds":"(indol-3-yl)butanoate + ATP + L-glutamine => (indol-3-yl)butanoyl-L-glutamine + AMP + diphosphate + H(+)"}
{"X":56671,"RHEA_ID":59061,"DIRECTION":"LR","MASTER_ID":59060,"metacyc":"RXN-11142","compounds":"(20S)-ginsenoside Rg3 + H2O => (20S)-ginsenoside Rh2 + D-glucose"}
{"X":56672,"RHEA_ID":62016,"compounds":"L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-(beta-D-xylosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP"}
{"X":56673,"RHEA_ID":59869,"compounds":"4-(2,4-dichlorophenoxy)butanoate + ATP + L-glutamine => 4-(2,4-dichlorophenoxy)butanoyl-L-glutamine + AMP + diphosphate + H(+)"}
{"X":56674,"RHEA_ID":62466,"compounds":"2-nonadioyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O"}
{"X":56675,"RHEA_ID":58319,"compounds":"beta-D-glucosyl-N-hexadecanoylsphing-4E-enine + cholesterol <=> cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine"}
{"X":56676,"RHEA_ID":56117,"DIRECTION":"LR","MASTER_ID":56116,"metacyc":"RXN-9232","compounds":"2-all-trans-decaprenylphenol + H(+) + NADPH + O2 => 3-(all-trans-decaprenyl)benzene-1,2-diol + H2O + NADP(+)"}
{"X":56677,"RHEA_ID":59873,"compounds":"L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP"}
{"X":56678,"RHEA_ID":62475,"compounds":"1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-nonadioyl-sn-glycero-3-phosphocholine"}
{"X":56679,"RHEA_ID":55350,"compounds":"9-cis-retinol => all-trans-retinol"}
{"X":56680,"RHEA_ID":59875,"compounds":"L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP"}
{"X":56681,"RHEA_ID":59877,"compounds":"(indol-3-yl)butanoate + ATP + L-cysteine => (indol-3-yl)butanoyl-L-cysteine + AMP + diphosphate + H(+)"}
{"X":56682,"RHEA_ID":61574,"compounds":"(15S)-hydroperoxy-(11Z,13E)-eicosadienoate => (11Z,14Z)-eicosadienoate + O2"}
{"X":56683,"RHEA_ID":58327,"compounds":"beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine + cholesterol <=> cholesteryl 3-beta-D-glucoside + N-(9Z-octadecenoyl)-sphing-4-enine"}
{"X":56684,"RHEA_ID":62028,"compounds":"H2O + stigmasteryl 3-beta-D-glucoside = D-glucose + stigmasterol"}
{"X":56685,"RHEA_ID":58699,"compounds":"NADPH + O2 + rifampicin <=> H(+) + H2O + NADP(+) + rifampicin para-naphthoquinone carboxamide"}
{"X":56686,"RHEA_ID":57963,"compounds":"dimethyl sulfide + H(+) + NADH + O2 <=> dimethyl sulfoxide + H2O + NAD(+)"}
{"X":56687,"RHEA_ID":61578,"DIRECTION":"RL","MASTER_ID":61576,"metacyc":"RXN-20418","compounds":"(3R,4R)-3,4-dihydroxycyclohexa-1,5-diene-1-carbonyl-CoA + H(+) + NADPH => (4R,5R)-4,5-dihydroxycyclohex-2-ene-1-carbonyl-CoA + NADP(+)"}
{"X":56688,"RHEA_ID":56492,"compounds":"hederagenin + O2 + reduced [NADPH--hemoprotein reductase] = gypsogenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":56689,"RHEA_ID":59884,"compounds":"2-oxoglutarate + chloride + H(+) + L-lysine + O2 = 4-chloro-L-lysine + CO2 + H2O + succinate"}
{"X":56690,"RHEA_ID":57967,"compounds":"germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":56691,"RHEA_ID":55362,"compounds":"9-cis-retinol => 11-cis-retinol"}
{"X":56692,"RHEA_ID":56496,"compounds":"gypsogenin + O2 + reduced [NADPH--hemoprotein reductase] = gypsogenate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":56693,"RHEA_ID":58707,"compounds":"rifampicin hemiaminal <=> rifampicin ortho-naphthoquinone carboxamide"}
{"X":56694,"RHEA_ID":58708,"compounds":"rifampicin ortho-naphthoquinone carboxamide = rifampicin para-naphthoquinone carboxamide"}
{"X":56695,"RHEA_ID":61586,"compounds":"5-methylcytidine(72) in tRNA(Cys) + H(+) + S-adenosyl-L-homocysteine => cytidine(72) in tRNA(Cys) + S-adenosyl-L-methionine"}
{"X":56696,"RHEA_ID":62514,"compounds":"2-hydroxymelatonin + CO2 + succinate => 2-oxoglutarate + melatonin + O2"}
{"X":56697,"RHEA_ID":57603,"compounds":"2 [Fe(II)-cytochrome b5] + a 1-hexacosanoyl-2-acyl-phosphoglycerolipid + 2 H(+) + O2 <=> 2 [Fe(III)-cytochrome b5] + a 1-[(17Z)-hexacos-17-enoyl]-2-acyl-phosphoglycerolipid + 2 H2O"}
{"X":56698,"RHEA_ID":58712,"compounds":"NADH + O2 + rifampicin = H(+) + H2O + NAD(+) + rifampicin para-naphthoquinone carboxamide"}
{"X":56699,"RHEA_ID":57976,"DIRECTION":"UN","MASTER_ID":57976,"ec":"2.4.1.363","compounds":"(20S)-protopanaxadiol + UDP-alpha-D-glucose = (20S)-ginsenoside C-K + H(+) + UDP"}
{"X":56700,"RHEA_ID":59090,"compounds":"(2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine => D-histidine + S-adenosyl-L-methionine"}
{"X":56701,"RHEA_ID":58345,"compounds":"beta-D-glucosyl-(1->3)-O-lithocholate + H2O => D-glucose + lithocholate"}
{"X":56702,"RHEA_ID":58716,"compounds":"FADH2-C4alpha-hydroperoxide + NADH + rifampicin = FADH2 + H(+) + H2O + NAD(+) + rifampicin hemiaminal"}
{"X":56703,"RHEA_ID":61599,"compounds":"[DsbD protein]-dithiol + [thioredoxin]-disulfide <=> [DsbD protein]-disulfide + [thioredoxin]-dithiol"}
{"X":56704,"RHEA_ID":59900,"compounds":"2-oxoglutarate + L-gamma-glutamyl-L-propargylglycine + O2 = CO2 + L-gamma-glutamyl-(3R)-L-beta-ethynylserine + succinate"}
{"X":56705,"RHEA_ID":55380,"DIRECTION":"UN","MASTER_ID":55380,"ec":"1.1.1.395","compounds":"a 3alpha-hydroxy bile acid CoA + NAD(+) = a 3-oxo bile acid CoA + H(+) + NADH"}
{"X":56706,"RHEA_ID":55381,"compounds":"a 3alpha-hydroxy bile acid CoA + NAD(+) => a 3-oxo bile acid CoA + H(+) + NADH"}
{"X":56707,"RHEA_ID":55382,"compounds":"a 3-oxo bile acid CoA + H(+) + NADH => a 3alpha-hydroxy bile acid CoA + NAD(+)"}
{"X":56708,"RHEA_ID":62526,"compounds":"H(+) + N(4)-methylcytidine(839) in 12S rRNA + S-adenosyl-L-homocysteine => cytidine(839) in 12S rRNA + S-adenosyl-L-methionine"}
{"X":56709,"RHEA_ID":55384,"compounds":"(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 6 isopentenyl diphosphate = 6 diphosphate + tetra-trans,hexa-cis-undecaprenyl diphosphate"}
{"X":56710,"RHEA_ID":59100,"DIRECTION":"UN","MASTER_ID":59100,"ec":"2.4.1.369","compounds":"diglucosyl-enterobactin + UDP-alpha-D-glucose = H(+) + triglucosyl-enterobactin + UDP"}
{"X":56711,"RHEA_ID":57988,"DIRECTION":"UN","MASTER_ID":57988,"ec":"2.4.1.363","compounds":"(20S)-ginsenoside Rh2 + UDP-alpha-D-glucose = (20S)-ginsenoside F2 + H(+) + UDP"}
{"X":56712,"RHEA_ID":56878,"compounds":"(R)-1-phenylethylamine + acetate => (R)-N-acetyl-1-phenylethylamine + H2O"}
{"X":56713,"RHEA_ID":60299,"compounds":"L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":56714,"RHEA_ID":55389,"compounds":"(3R)-3-hydroxy-2,3-dihydrotabersonine + A => (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + AH2"}
{"X":56715,"RHEA_ID":55390,"DIRECTION":"RL","MASTER_ID":55388,"metacyc":"RXN-18621","compounds":"(3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + AH2 => (3R)-3-hydroxy-2,3-dihydrotabersonine + A"}
{"X":56716,"RHEA_ID":57622,"compounds":"H(+) + 2 H2O + ML-236C carboxylate + oxidized [NADPH--hemoprotein reductase] => dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":56717,"RHEA_ID":61208,"compounds":"8-nitro-cGMP + L-cysteinyl-[protein] = H(+) + nitrite + S-(guanosine 3',5'-cyclic phosphate)-L-cysteinyl-[protein]"}
{"X":56718,"RHEA_ID":57995,"compounds":"(20S)-ginsenoside C-K + UDP-alpha-D-glucose <=> (20S)-ginsenoside F2 + H(+) + UDP"}
{"X":56719,"RHEA_ID":55394,"compounds":"H(+) + N(1)-methyladenosine in mRNA + S-adenosyl-L-homocysteine => adenosine in mRNA + S-adenosyl-L-methionine"}
{"X":56720,"RHEA_ID":59916,"compounds":"(2E)-octenal + H2O + NADP(+) = (2E)-octenoate + 2 H(+) + NADPH"}
{"X":56721,"RHEA_ID":59518,"compounds":"H(+) + N(6)-acetyl-L-lysyl-[protein] + salicylate => acetylsalicylate + L-lysyl-[protein]"}
{"X":56722,"RHEA_ID":58736,"compounds":"5-methyl-UTP + H2O = 5-methyl-UMP + diphosphate + H(+)"}
{"X":56723,"RHEA_ID":58737,"compounds":"5-methyl-UTP + H2O => 5-methyl-UMP + diphosphate + H(+)"}
{"X":56724,"RHEA_ID":59920,"compounds":"(2E)-octenal + H2O + NAD(+) = (2E)-octenoate + 2 H(+) + NADH"}
{"X":56725,"RHEA_ID":55400,"compounds":"7-cyano-7-carbaguanosine(15) in tRNA + NH4(+) = archaeosine(15) in tRNA"}
{"X":56726,"RHEA_ID":58740,"compounds":"H2O + psi-UTP = diphosphate + H(+) + psi-UMP"}
{"X":56727,"RHEA_ID":55402,"compounds":"archaeosine(15) in tRNA => 7-cyano-7-carbaguanosine(15) in tRNA + NH4(+)"}
{"X":56728,"RHEA_ID":59928,"compounds":"erythritol + NADP(+) = D-erythrose + H(+) + NADPH"}
{"X":56729,"RHEA_ID":58743,"compounds":"H2O + psi-UTP <=> diphosphate + H(+) + psi-UMP"}
{"X":56730,"RHEA_ID":59527,"compounds":"9S,10-epoxy-(10,12Z)-octadecadienoate + H(+) + L-aspartyl-[protein] <=> 9-O-10-oxo-(12Z)-octadecenoate L-aspartatyl ester-[protein]"}
{"X":56731,"RHEA_ID":56535,"compounds":"H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine phosphate <=> N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + phosphate"}
{"X":56732,"RHEA_ID":62550,"compounds":"beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + H(+) + UDP => a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + UDP-alpha-D-galactose"}
{"X":56733,"RHEA_ID":58747,"compounds":"7-methyl-GTP + H2O <=> 7-methyl-GMP + diphosphate + H(+)"}
{"X":56734,"RHEA_ID":55409,"compounds":"[phosphate](n) + CTP => [phosphate](n+1) + CDP"}
{"X":56735,"RHEA_ID":55410,"compounds":"[phosphate](n+1) + CDP => [phosphate](n) + CTP"}
{"X":56736,"RHEA_ID":59940,"compounds":"2-methyloctadecanoyl-CoA + H2O = 2-methyloctadecanoate + CoA + H(+)"}
{"X":56737,"RHEA_ID":57643,"compounds":"14 H(+) + holo-[equisetin nonaketide synthase] + 8 malonyl-CoA + 8 NADPH + 2 S-adenosyl-L-methionine <=> (3-{(1R,2S,6S,8R)-2,8-dimethyl-3-[(E)-prop-1-enyl]-4,5-didehydrodecalin-2-yl}-3-oxopropanoyl)-[equisetin nonaketide synthase] + 8 CO2 + 8 CoA + 6 H2O + 8 NADP(+) + 2 S-adenosyl-L-homocysteine"}
{"X":56738,"RHEA_ID":58752,"compounds":"1-hexadecanoyl-2-(7-oxoheptanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH = 1-hexadecanoyl-2-(7-hydroxyheptanoyl)-sn-glycero-3-phosphocholine + NADP(+)"}
{"X":56739,"RHEA_ID":55414,"compounds":"[phosphate](n+1) + GDP => [phosphate](n) + GTP"}
{"X":56740,"RHEA_ID":61232,"compounds":"H2O + L-isoleucine + O2 = (S)-3-methyl-2-oxopentanoate + H2O2 + NH4(+)"}
{"X":56741,"RHEA_ID":58755,"compounds":"1-hexadecanoyl-2-(7-oxoheptanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH <=> 1-hexadecanoyl-2-(7-hydroxyheptanoyl)-sn-glycero-3-phosphocholine + NADP(+)"}
{"X":56742,"RHEA_ID":59132,"DIRECTION":"UN","MASTER_ID":59132,"ec":"6.3.2.56","compounds":"2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + 2-oxoglutarate + ATP = AMP + diphosphate + H(+) + staphyloferrin B"}
{"X":56743,"RHEA_ID":55418,"compounds":"biochanin A 7-O-beta-D-glucoside + H(+) + UDP => biochanin A + UDP-alpha-D-glucose"}
{"X":56744,"RHEA_ID":62570,"compounds":"glycine + S-benzyl-L-cysteine => H2O + S-benzyl-L-cysteinylglycine"}
{"X":56745,"RHEA_ID":58759,"compounds":"1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphoethanolamine + H(+) + NADPH <=> 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphoethanolamine + NADP(+)"}
{"X":56746,"RHEA_ID":58760,"compounds":"1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + NADPH = 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + NADP(+)"}
{"X":56747,"RHEA_ID":55422,"compounds":"CoA + H(+) + N(6)-hexadecanoyl-L-lysyl-[protein] => hexadecanoyl-CoA + L-lysyl-[protein]"}
{"X":56748,"RHEA_ID":58762,"compounds":"1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + NADP(+) => 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + NADPH"}
{"X":56749,"RHEA_ID":59961,"compounds":"N(alpha)-acetyl-D-methionine => N(alpha)-acetyl-L-methionine"}
{"X":56750,"RHEA_ID":58764,"compounds":"1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphate + H(+) + NADPH = 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphate + NADP(+)"}
{"X":56751,"RHEA_ID":55426,"compounds":"(3E)-4,8-dimethylnona-1,3,7-triene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (3S,6E)-nerolidol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":56752,"RHEA_ID":58766,"compounds":"1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphate + NADP(+) => 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphate + H(+) + NADPH"}
{"X":56753,"RHEA_ID":62577,"DIRECTION":"LR","MASTER_ID":62576,"ecocyc":"TRANS-RXN0-593","metacyc":"TRANS-RXN0-593","compounds":"ATP + H2O + L-cystine(out) => ADP + H(+) + L-cystine(in) + phosphate"}
{"X":56754,"RHEA_ID":59144,"compounds":"10-formyldihydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + 7,8-dihydrofolate"}
{"X":56755,"RHEA_ID":55430,"compounds":"11-hydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ferruginol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":56756,"RHEA_ID":58770,"compounds":"1-O-(1Z-hexadecenyl)-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+) => 1-O-(1Z-hexadecenyl)-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH"}
{"X":56757,"RHEA_ID":55432,"DIRECTION":"UN","MASTER_ID":55432,"ec":"1.14.14.61","compounds":"11-hydroxyferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = carnosate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}
{"X":56758,"RHEA_ID":59164,"DIRECTION":"UN","MASTER_ID":59164,"ec":"6.2.1.57","compounds":"ATP + hexadecanoate + holo-[(hydroxy)phthioceranic acid synthase] = AMP + diphosphate + hexadecanoyl-[(hydroxy)phthioceranic acid synthase]"}
{"X":56759,"RHEA_ID":55434,"compounds":"carnosate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 11-hydroxyferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]"}
{"X":56760,"RHEA_ID":58774,"compounds":"1-O-hexadecyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+) => 1-O-hexadecyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH"}
{"X":56761,"RHEA_ID":62585,"DIRECTION":"LR","MASTER_ID":62584,"metacyc":"TRANS-RXN-390","compounds":"ATP + H2O + L-tyrosine(out) => ADP + H(+) + L-tyrosine(in) + phosphate"}
{"X":56762,"RHEA_ID":58776,"compounds":"NADP(+) + pyridine 3-methanol = H(+) + NADPH + pyridine-3-carbaldehyde"}
{"X":56763,"RHEA_ID":56565,"compounds":"3-O-(beta-D-glucosyl)-L-threonyl-[EGF-like domain protein] + UDP-alpha-D-xylose => 3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-threonyl-[EGF-like domain protein] + H(+) + UDP"}
{"X":56764,"RHEA_ID":56567,"compounds":"3-O-(beta-D-glucosyl)-L-threonyl-[EGF-like domain protein] + UDP-alpha-D-xylose <=> 3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-threonyl-[EGF-like domain protein] + H(+) + UDP"}
{"X":56765,"RHEA_ID":59976,"DIRECTION":"UN","MASTER_ID":59976,"ec":"4.1.1.119","compounds":"2-phenylacetate + H(+) = CO2 + toluene"}
{"X":56766,"RHEA_ID":61718,"compounds":"ADP + D-galactofuranose(in) + H(+) + phosphate => ATP + D-galactofuranose(out) + H2O"}
{"X":56767,"RHEA_ID":58781,"compounds":"a 5'-triphospho-guanosine-ribonucleotide-snRNA + S-adenosyl-L-methionine => a 5'-methyltriphosphate-guanosine-ribonucleotide-snRNA + S-adenosyl-L-homocysteine"}
{"X":56768,"RHEA_ID":58782,"compounds":"a 5'-methyltriphosphate-guanosine-ribonucleotide-snRNA + S-adenosyl-L-homocysteine => a 5'-triphospho-guanosine-ribonucleotide-snRNA + S-adenosyl-L-methionine"}
{"X":56769,"RHEA_ID":55444,"DIRECTION":"UN","MASTER_ID":55444,"ec":"1.14.14.63","compounds":"O2 + oleanolate + reduced [NADPH--hemoprotein reductase] = cochalate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":56770,"RHEA_ID":55445,"DIRECTION":"LR","MASTER_ID":55444,"metacyc":"RXN-18883","compounds":"O2 + oleanolate + reduced [NADPH--hemoprotein reductase] => cochalate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":56771,"RHEA_ID":62597,"compounds":"(S)-8-oxocitronellyl enol + NAD(+) => (6E)-8-oxogeranial + H(+) + NADH"}
{"X":56772,"RHEA_ID":59568,"DIRECTION":"UN","MASTER_ID":59568,"ec":"6.3.2.11","compounds":"4-aminobutanoate + ATP + L-histidine = ADP + H(+) + L-homocarnosine + phosphate"}
{"X":56773,"RHEA_ID":55448,"DIRECTION":"UN","MASTER_ID":55448,"ec":"1.14.14.81","compounds":"a 3',5'-unsubstituted flavanone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = a 3',5'-dihydroxyflavanone + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":56774,"RHEA_ID":55449,"DIRECTION":"LR","MASTER_ID":55448,"metacyc":"RXN-13192","compounds":"a 3',5'-unsubstituted flavanone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => a 3',5'-dihydroxyflavanone + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":56775,"RHEA_ID":58793,"compounds":"ATP + Fe(III)-petrobactin(out) + H2O => ADP + Fe(III)-petrobactin(in) + H(+) + phosphate"}
{"X":56776,"RHEA_ID":58794,"compounds":"ADP + Fe(III)-petrobactin(in) + H(+) + phosphate => ATP + Fe(III)-petrobactin(out) + H2O"}
{"X":56777,"RHEA_ID":55452,"DIRECTION":"UN","MASTER_ID":55452,"ec":"1.14.14.64","compounds":"beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = daturadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":56778,"RHEA_ID":58796,"compounds":"a flavonol 7-O-beta-D-glucoside + malonyl-CoA = a flavonol 7-O-(6-O-malonyl-beta-D-glucoside) + CoA"}
{"X":56779,"RHEA_ID":61271,"compounds":"H2O + L-2-aminohexanoate + O2 <=> 2-oxohexanoate + H2O2 + NH4(+)"}
{"X":56780,"RHEA_ID":57694,"compounds":"2 cob(I)inamide--[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein] => 2 cob(II)inamide--[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein]"}
{"X":56781,"RHEA_ID":61273,"compounds":"H2O + L-2-aminopentanoate + O2 => 2-oxopentanoate + H2O2 + NH4(+)"}
{"X":56782,"RHEA_ID":59994,"DIRECTION":"RL","MASTER_ID":59992,"metacyc":"RXN-19888","compounds":"reduced [electron-transfer flavoprotein] + trans-4-coumarate => H(+) + oxidized [electron-transfer flavoprotein] + phloretate"}
{"X":56783,"RHEA_ID":58801,"compounds":"3',3'-cGAMP + H2O => 5'-pApG-3' + H(+)"}
{"X":56784,"RHEA_ID":57698,"compounds":"adenosylcob(III)inamide + apo-[corrinoid adenosyltransferase] + triphosphate => ATP + cob(I)inamide--[corrinoid adenosyltransferase]"}
{"X":56785,"RHEA_ID":58803,"compounds":"3',3'-cGAMP + H2O <=> 5'-pApG-3' + H(+)"}
{"X":56786,"RHEA_ID":58804,"compounds":"5'-pApG-3' + H2O = 5'-ApG-3' + phosphate"}
{"X":56787,"RHEA_ID":55462,"compounds":"11-hydroxysugiol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => 11-hydroxyferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]"}
{"X":56788,"RHEA_ID":58807,"compounds":"5'-pApG-3' + H2O <=> 5'-ApG-3' + phosphate"}
{"X":56789,"RHEA_ID":55465,"DIRECTION":"LR","MASTER_ID":55464,"metacyc":"RXN-18903","compounds":"11-hydroxysugiol + O2 + reduced [NADPH--hemoprotein reductase] => 11,20-dihydroxysugiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":56790,"RHEA_ID":55466,"compounds":"11,20-dihydroxysugiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 11-hydroxysugiol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":56791,"RHEA_ID":56958,"compounds":"H(+) + IDP + phosphoenolpyruvate => ITP + pyruvate"}
{"X":56792,"RHEA_ID":55468,"DIRECTION":"UN","MASTER_ID":55468,"ec":"1.14.14.67","compounds":"11-hydroxyferruginol + O2 + reduced [NADPH--hemoprotein reductase] = 11,20-dihydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":56793,"RHEA_ID":58812,"DIRECTION":"UN","MASTER_ID":58812,"ec":"5.1.1.23","compounds":"ATP + H2O + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate = AMP + diphosphate + H(+) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate"}
{"X":56794,"RHEA_ID":58813,"DIRECTION":"LR","MASTER_ID":58812,"metacyc":"RXN-19252","compounds":"ATP + H2O + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate => AMP + diphosphate + H(+) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate"}
{"X":56795,"RHEA_ID":55858,"compounds":"all-trans-18-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":56796,"RHEA_ID":62144,"compounds":"dGMP + dGTP = 2 dGDP"}
{"X":56797,"RHEA_ID":61290,"compounds":"5-deoxy-alpha-D-ribose 1-phosphate + ADP + H(+) => 5-deoxy-alpha-D-ribose + ATP"}
{"X":56798,"RHEA_ID":60878,"compounds":"a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+) => a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O"}
{"X":56799,"RHEA_ID":59221,"DIRECTION":"LR","MASTER_ID":59220,"metacyc":"2-OH-6-OXOHEPTA-2-4-DIENOATE-HYDR-RXN","compounds":"(2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate + H2O => (2Z)-2-hydroxypenta-2,4-dienoate + acetate + H(+)"}
{"X":56800,"RHEA_ID":62651,"compounds":"(12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 <=> (5S)-hydroperoxy-(12S)-hydroxy-(6E,8Z,10E,14Z)-eicosatetraenoate"}
{"X":56801,"RHEA_ID":55477,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + N-acyleicosasphinganine + O2 => 2 [Fe(III)-cytochrome b5] + H2O + N-acyl-4-hydroxyeicosasphinganine"}
{"X":56802,"RHEA_ID":56606,"compounds":"6-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n)"}
{"X":56803,"RHEA_ID":60015,"compounds":"a tRNA with a 3' CC end + ATP <=> a tRNA with a 3' CCA end + diphosphate"}
{"X":56804,"RHEA_ID":58822,"compounds":"acetate + CO2 + Na(+)(out) => H(+) + malonate + Na(+)(in)"}
{"X":56805,"RHEA_ID":55481,"DIRECTION":"LR","MASTER_ID":55480,"metacyc":"RXN-19373","compounds":"ent-cassa-12,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => ent-3beta-hydroxycassa-12,15-dien-2-one + 3 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}
{"X":56806,"RHEA_ID":55481,"DIRECTION":"LR","MASTER_ID":55480,"metacyc":"RXN-18947","compounds":"ent-cassa-12,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => ent-3beta-hydroxycassa-12,15-dien-2-one + 3 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]"}
{"X":56807,"RHEA_ID":60020,"compounds":"(2E,6E)-farnesyl diphosphate = diphosphate + sesquisabinene A"}
{"X":56808,"RHEA_ID":62659,"compounds":"2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + dimethylallyl diphosphate <=> 2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol + diphosphate"}
{"X":56809,"RHEA_ID":55484,"compounds":"ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase] = ent-cassa-12,15-dien-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":56810,"RHEA_ID":56614,"compounds":"H(+) + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein] => L-cysteinyl-[protein] + NAD(+)"}
{"X":56811,"RHEA_ID":58829,"compounds":"(9S,10R)-epoxy-octadecanoate + H2O => 9R,10R-dihydroxyoctadecanoate"}
{"X":56812,"RHEA_ID":58831,"compounds":"(9S,10R)-epoxy-octadecanoate + H2O <=> 9R,10R-dihydroxyoctadecanoate"}
{"X":56813,"RHEA_ID":61306,"compounds":"H(+) + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + UDP => N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + UDP-alpha-D-glucose"}
{"X":56814,"RHEA_ID":56618,"compounds":"1,2,4-trichlorobenzene + chloride + H(+) => (3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene"}
{"X":56815,"RHEA_ID":59237,"DIRECTION":"LR","MASTER_ID":59236,"metacyc":"RXN-20048","compounds":"all-trans-geranylgeranyl diphosphate => diphosphate + isoelisabethatriene"}
{"X":56816,"RHEA_ID":58460,"compounds":"an acyl-CoA + sn-glycerol 3-phosphocholine = a monoacyl-sn-glycero-3-phosphocholine + CoA"}
{"X":56817,"RHEA_ID":57350,"compounds":"3-hydroxy-4-methylanthranilate + H(+) + L-alanine => 3-hydroxy-4-methyl-L-kynurenine + H2O"}
{"X":56818,"RHEA_ID":62170,"compounds":"acetate + beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine => H2O + N,N'-diacetylchitobiose"}
{"X":56819,"RHEA_ID":55494,"compounds":"ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2-one + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":56820,"RHEA_ID":59628,"DIRECTION":"UN","MASTER_ID":59628,"ec":"3.4.13.4","compounds":"H2O + N(2)-(4-aminobutanoyl)-L-arginine = 4-aminobutanoate + L-arginine"}
{"X":56821,"RHEA_ID":55496,"compounds":"ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = ent-cassa-12,15-dien-2beta,3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":56822,"RHEA_ID":55497,"DIRECTION":"LR","MASTER_ID":55496,"metacyc":"RXN-18945","compounds":"ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2beta,3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":56823,"RHEA_ID":58842,"compounds":"(24S)-hydroxycholesterol 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol sulfate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":56824,"RHEA_ID":62675,"compounds":"a 2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-methionine <=> an N(6)-methyl-2'-O-methyladenosine in U2 snRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":56825,"RHEA_ID":55500,"compounds":"ent-cassa-12,15-dien-2beta,3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":56826,"RHEA_ID":58845,"compounds":"(6E)-8-hydroxygeranial + NAD(+) => (6E)-8-oxogeranial + H(+) + NADH"}
{"X":56827,"RHEA_ID":58846,"compounds":"(6E)-8-oxogeranial + H(+) + NADH => (6E)-8-hydroxygeranial + NAD(+)"}
{"X":56828,"RHEA_ID":61780,"compounds":"keto-L-tagatose = keto-L-sorbose"}
{"X":56829,"RHEA_ID":62181,"compounds":"H2O + peregrinol diphosphate => diphosphate + viteagnusin D"}
{"X":56830,"RHEA_ID":59638,"compounds":"D-xylotriono-1,5-lactone + H2O2 => D-xylotriose + O2"}
{"X":56831,"RHEA_ID":60044,"compounds":"beta-D-Gal-(1<->1')-Cer + UDP-alpha-D-galactose = alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer + H(+) + UDP"}
{"X":56832,"RHEA_ID":56636,"compounds":"1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate"}
{"X":56833,"RHEA_ID":55508,"DIRECTION":"UN","MASTER_ID":55508,"ec":"1.14.14.71","compounds":"cucurbitadienol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 11-oxocucurbitadienol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":56834,"RHEA_ID":56638,"compounds":"2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":56835,"RHEA_ID":60048,"DIRECTION":"UN","MASTER_ID":60048,"ec":"1.14.13.246","compounds":"a 3beta-hydroxy-4,4-dimethylsteroid + 2 H(+) + 3 NADH + 3 O2 = a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + 4 H2O + 3 NAD(+)"}
{"X":56836,"RHEA_ID":60440,"DIRECTION":"UN","MASTER_ID":60440,"ec":"3.1.1.114","compounds":"H2O + methyl acetate = acetate + H(+) + methanol"}
{"X":56837,"RHEA_ID":61330,"compounds":"3beta-hydroxyparthenolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + parthenolide + reduced [NADPH--hemoprotein reductase]"}
{"X":56838,"RHEA_ID":59261,"DIRECTION":"LR","MASTER_ID":59260,"ecocyc":"RXN-20023","metacyc":"RXN-20023","compounds":"Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+) + H2O => Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine"}
{"X":56839,"RHEA_ID":58115,"compounds":"1''-O-acetyl-ADP-alpha-D-ribose + H2O <=> acetate + ADP-D-ribose + H(+)"}
{"X":56840,"RHEA_ID":62691,"compounds":"4 norrubrofusarin + O2 <=> 2 H2O + 2 ustilaginoidin A"}
{"X":56841,"RHEA_ID":58860,"compounds":"4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":56842,"RHEA_ID":58119,"compounds":"L-seryl-[EGF-like domain protein] + UDP-alpha-D-glucose <=> 3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP"}
{"X":56843,"RHEA_ID":60056,"compounds":"a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H(+) + NADH + O2 = a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + 2 H2O + NAD(+)"}
{"X":56844,"RHEA_ID":58489,"compounds":"4-(trimethylamino)butanoate + H(+) + NADH + O2 => H2O + NAD(+) + succinate semialdehyde + trimethylamine"}
{"X":56845,"RHEA_ID":60456,"compounds":"ATP + UTP = 3',3'-cUAMP + 2 diphosphate"}
{"X":56846,"RHEA_ID":58123,"compounds":"ATP + L-seryl-[protein] <=> 3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate"}
{"X":56847,"RHEA_ID":59269,"compounds":"A + H2O + N(6)-methyl-L-lysyl-[protein] => AH2 + formaldehyde + L-lysyl-[protein]"}
{"X":56848,"RHEA_ID":62200,"compounds":"2 [Fe(III)cytochrome c] + ethanol = 2 [Fe(II)cytochrome c] + acetaldehyde + 2 H(+)"}
{"X":56849,"RHEA_ID":55524,"DIRECTION":"UN","MASTER_ID":55524,"ec":"4.1.1.107","compounds":"H(+) + H2O + L-dopa + O2 = 3,4-dihydroxyphenylacetaldehyde + CO2 + H2O2 + NH4(+)"}
{"X":56850,"RHEA_ID":62713,"compounds":"betaenone C + H(+) + NADPH + O2 => H2O + NADP(+) + stemphyloxin I"}
{"X":56851,"RHEA_ID":59273,"compounds":"L-cysteine => D-cysteine"}
{"X":56852,"RHEA_ID":61345,"compounds":"H2O + L-serine + O2 => 3-hydroxypyruvate + H2O2 + NH4(+)"}
{"X":56853,"RHEA_ID":58872,"compounds":"24-methylidenelophenol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":56854,"RHEA_ID":61346,"compounds":"3-hydroxypyruvate + H2O2 + NH4(+) => H2O + L-serine + O2"}
{"X":56855,"RHEA_ID":61831,"compounds":"stigmasterol + UDP-alpha-D-glucose <=> H(+) + stigmasteryl 3-beta-D-glucoside + UDP"}
{"X":56856,"RHEA_ID":58875,"compounds":"24-methylidenelophenol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":56857,"RHEA_ID":55532,"DIRECTION":"UN","MASTER_ID":55532,"ec":"4.1.1.109","compounds":"H(+) + H2O + L-phenylalanine + O2 = 2-phenylacetaldehyde + CO2 + H2O2 + NH4(+)"}
{"X":56858,"RHEA_ID":62721,"compounds":"3 H(+) + 3 NADPH + 3 O2 + probetaenone I => betaenone B + 3 H2O + 3 NADP(+)"}
{"X":56859,"RHEA_ID":59281,"compounds":"L-asparagine => D-asparagine"}
{"X":56860,"RHEA_ID":56663,"compounds":"7alpha-hydroxy-3-oxochol-24-oyl-CoA + NAD(+) <=> 7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH"}
{"X":56861,"RHEA_ID":58878,"compounds":"4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}
{"X":56862,"RHEA_ID":58881,"DIRECTION":"LR","MASTER_ID":58880,"metacyc":"RXN-11932","compounds":"4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 => 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":56863,"RHEA_ID":56667,"compounds":"7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + NAD(+) <=> 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH"}
{"X":56864,"RHEA_ID":58882,"compounds":"4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O => 4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2"}
{"X":56865,"RHEA_ID":59288,"compounds":"beta-D-glucosyl-(1<->1)-sphing-4-enine + H2O = D-glucose + sphing-4-enine"}
{"X":56866,"RHEA_ID":57033,"compounds":"(E)-2-((N-methylformamido) methylene)succinate + H(+) + 2 H2O => CO2 + formate + methylamine + succinate semialdehyde"}
{"X":56867,"RHEA_ID":62220,"compounds":"phyllostine = neopatulin"}
{"X":56868,"RHEA_ID":62731,"compounds":"(+)-malbrancheamide B + bromide + FAD + 2 H(+) <=> (+)-malbrancheamide D + FADH2"}
{"X":56869,"RHEA_ID":58896,"DIRECTION":"UN","MASTER_ID":58896,"ec":"6.2.1.56","compounds":"4-hydroxybutanoate + ATP + CoA = 4-hydroxybutanoyl-CoA + ADP + phosphate"}
{"X":56870,"RHEA_ID":61847,"compounds":"solasodine + UDP-alpha-D-glucose <=> H(+) + solasodine 3-beta-D-glucoside + UDP"}
{"X":56871,"RHEA_ID":58898,"compounds":"4-hydroxybutanoyl-CoA + ADP + phosphate => 4-hydroxybutanoate + ATP + CoA"}
{"X":56872,"RHEA_ID":58149,"DIRECTION":"LR","MASTER_ID":58148,"metacyc":"RXN-17577","compounds":"ethyl acetate + H2O => acetate + ethanol + H(+)"}
{"X":56873,"RHEA_ID":58900,"DIRECTION":"UN","MASTER_ID":58900,"ec":"3.5.1.131","compounds":"1-carboxybiuret + H2O = NH4(+) + urea-1,3-dicarboxylate"}
{"X":56874,"RHEA_ID":60486,"compounds":"cyclic CMP-UMP + 2 diphosphate => CTP + UTP"}
{"X":56875,"RHEA_ID":58902,"compounds":"NH4(+) + urea-1,3-dicarboxylate => 1-carboxybiuret + H2O"}
{"X":56876,"RHEA_ID":62739,"compounds":"1-hydroxy-3-(1H-indol-3-ylmethyl)-6H,7H,8H-5lambda5-pyrrolo[1,2-a]pyrazin-5-ylium + dimethylallyl diphosphate <=> 1-hydroxy-3-{[2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl]methyl}-6H,7H,8H-5lambda5-pyrrolo[1,2-a]pyrazine + diphosphate"}
{"X":56877,"RHEA_ID":60089,"DIRECTION":"LR","MASTER_ID":60088,"metacyc":"RXN-20109","compounds":"a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NADP(+) => a 4alpha-methyl-3-oxosteroid + CO2 + NADPH"}
{"X":56878,"RHEA_ID":55553,"compounds":"N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine"}
{"X":56879,"RHEA_ID":55554,"compounds":"H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine"}
{"X":56880,"RHEA_ID":55555,"compounds":"N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine"}
{"X":56881,"RHEA_ID":61374,"compounds":"4-methylumbelliferone beta-D-glucuronate(out) + ADP + H(+) + phosphate => 4-methylumbelliferone beta-D-glucuronate(in) + ATP + H2O"}
{"X":56882,"RHEA_ID":55557,"compounds":"a hydroperoxyeicosatetraenoate => an oxoeicosatetraenoate + H2O"}
{"X":56883,"RHEA_ID":58910,"compounds":"C37-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 7 CO2 + 7 CoA + 7 H2O + 14 NADP(+) => 7 (S)-methylmalonyl-CoA + 21 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 14 NADPH"}
{"X":56884,"RHEA_ID":58529,"compounds":"15alpha-stemmadenine intermediate I + H2O + NADPH => (16R)-deshydroxymethyl-stemmadenine + formate + NADP(+)"}
{"X":56885,"RHEA_ID":60096,"DIRECTION":"UN","MASTER_ID":60096,"ec":"1.1.1.417","compounds":"4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholesta-8,24-dien-3-one + CO2 + NADPH"}
{"X":56886,"RHEA_ID":57801,"compounds":"2,3-dinitrotoluene + NADH + O2 => 4-methyl-3-nitrocatechol + H(+) + NAD(+) + nitrite"}
{"X":56887,"RHEA_ID":56327,"compounds":"a methylphosphotriester deoxyribonucleoside in DNA + L-cysteinyl-[protein] <=> a deoxyribonucleotide in DNA + H(+) + S-methyl-L-cysteinyl-[protein]"}
{"X":56888,"RHEA_ID":58916,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + squalene = (S)-2,3-epoxysqualene + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":56889,"RHEA_ID":58915,"compounds":"ATP + H2O + iron(III) dicitrate(out) <=> ADP + H(+) + iron(III) dicitrate(in) + phosphate"}
{"X":56890,"RHEA_ID":58918,"compounds":"(S)-2,3-epoxysqualene + 2 [Fe(III)-cytochrome b5] + H2O => 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + squalene"}
{"X":56891,"RHEA_ID":58919,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 + squalene <=> (S)-2,3-epoxysqualene + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":56892,"RHEA_ID":58920,"DIRECTION":"UN","MASTER_ID":58920,"ec":"4.2.1.139","compounds":"(3S,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol = (+)-medicarpin + H2O"}
{"X":56893,"RHEA_ID":55569,"DIRECTION":"LR","MASTER_ID":55568,"metacyc":"RXN-19093","compounds":"4-hydoxytryptamine 4-phosphate + 2 S-adenosyl-L-methionine => 2 H(+) + psilocybin + 2 S-adenosyl-L-homocysteine"}
{"X":56894,"RHEA_ID":62770,"compounds":"4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O => 4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2"}
{"X":56895,"RHEA_ID":57430,"compounds":"formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] + phenol => anisole + O2 + reduced [NADH--hemoprotein reductase]"}
{"X":56896,"RHEA_ID":61390,"compounds":"ADP + biotin(out) + H(+) + phosphate => ATP + biotin(in) + H2O"}
{"X":56897,"RHEA_ID":59705,"compounds":"D-cellohexaono-1,5-lactone + H2O => D-cellohexaonate + H(+)"}
{"X":56898,"RHEA_ID":62778,"compounds":"4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O => 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2"}
{"X":56899,"RHEA_ID":58927,"compounds":"(3R,4R)-3-(6-hydroxy-1,3-benzodioxol-5-yl)-3,4-dihydro-2H-chromene-4,7-diol <=> (-)-maackiain + H2O"}
{"X":56900,"RHEA_ID":60113,"DIRECTION":"LR","MASTER_ID":60112,"metacyc":"RXN-19896","compounds":"(R)-3-(indol-3-yl)lactoyl-CoA => (E)-3-(indol-3-yl)acryloyl-CoA + H2O"}
{"X":56901,"RHEA_ID":58928,"DIRECTION":"UN","MASTER_ID":58928,"ec":"4.2.1.139","compounds":"(3R,4R)-7,2',4'-trihydroxyisoflavanol = (6aR,11aR)-3,9-dihydroxypterocarpan + H2O"}
{"X":56902,"RHEA_ID":60558,"compounds":"pseudouridine(35) in tRNA(Tyr) => uridine(35) in tRNA(Tyr)"}
{"X":56903,"RHEA_ID":58930,"compounds":"(6aR,11aR)-3,9-dihydroxypterocarpan + H2O => (3R,4R)-7,2',4'-trihydroxyisoflavanol"}
{"X":56904,"RHEA_ID":59857,"DIRECTION":"LR","MASTER_ID":59856,"metacyc":"RXN-8132","compounds":"[Co(I) tetramethylammonium-specific corrinoid protein] + H(+) + tetramethylammonium => [methyl-Co(III) tetramethylammonium-specific corrinoid protein] + trimethylamine"}
{"X":56905,"RHEA_ID":56467,"compounds":"1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H2O <=> 1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine"}
{"X":56906,"RHEA_ID":62260,"compounds":"2 hydrogencarbonate(out) + Mn(2+)(out) = 2 hydrogencarbonate(in) + Mn(2+)(in)"}
{"X":56907,"RHEA_ID":61885,"compounds":"1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl-9-hydroperoxy-20-hydroxy-(5Z,7E,11Z,14Z)-eicosatetraenoate"}
{"X":56908,"RHEA_ID":60120,"DIRECTION":"UN","MASTER_ID":60120,"ec":"2.1.1.363","compounds":"(2E,6E)-farnesyl diphosphate + S-adenosyl-L-methionine = H(+) + pre-sodorifen diphosphate + S-adenosyl-L-homocysteine"}
{"X":56909,"RHEA_ID":58936,"compounds":"2 all-trans-geranylgeranyl diphosphate + H(+) + NADH = all-trans-lycopaoctaene + 2 diphosphate + NAD(+)"}
{"X":56910,"RHEA_ID":57826,"compounds":"2-deoxy-D-ribose 5-phosphate + adenine => dAMP + H2O"}
{"X":56911,"RHEA_ID":57079,"compounds":"3-oxo-isoapionate 4-phosphate + H2O <=> 3-phosphoglycerate + glycolate + H(+)"}
{"X":56912,"RHEA_ID":57080,"compounds":"1-methylsulfanyl-D-xylulose 5-phosphate + glutathione = 1-deoxy-D-xylulose 5-phosphate + S-(methylsulfanyl)glutathione"}
{"X":56913,"RHEA_ID":61407,"compounds":"ATP + N-(D-ribulosyl)-cadaverine <=> ADP + H(+) + N-(3-O-phospho-D-ribulosyl)-cadaverine"}
{"X":56914,"RHEA_ID":61031,"compounds":"itaconate + L-cysteinyl-[protein] <=> S-(2,3-dicarboxypropyl)-L-cysteinyl-[protein]"}
{"X":56915,"RHEA_ID":58193,"DIRECTION":"LR","MASTER_ID":58192,"metacyc":"RXN-19166","compounds":"dimethylallyl diphosphate + H2O + isopentenyldehydrorhodopin => dihydrobisanhydrobacterioruberin + diphosphate"}
{"X":56916,"RHEA_ID":60576,"DIRECTION":"UN","MASTER_ID":60576,"ec":"2.1.1.253","compounds":"[methyl-Co(III) tetramethylammonium-specific corrinoid protein] + coenzyme M = [Co(I) tetramethylammonium-specific corrinoid protein] + H(+) + methyl-coenzyme M"}
{"X":56917,"RHEA_ID":60578,"compounds":"[Co(I) tetramethylammonium-specific corrinoid protein] + H(+) + methyl-coenzyme M => [methyl-Co(III) tetramethylammonium-specific corrinoid protein] + coenzyme M"}
{"X":56918,"RHEA_ID":58195,"compounds":"dimethylallyl diphosphate + H2O + isopentenyldehydrorhodopin <=> dihydrobisanhydrobacterioruberin + diphosphate"}
{"X":56919,"RHEA_ID":60580,"compounds":"(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":56920,"RHEA_ID":61901,"compounds":"AH2 + betaenone C => A + betaenone B"}
{"X":56921,"RHEA_ID":61415,"compounds":"ATP + N-(D-erythrulosyl)-cadaverine <=> ADP + H(+) + N-(3-O-phospho-D-erythrulosyl)-cadaverine"}
{"X":56922,"RHEA_ID":59345,"compounds":"D-maltose + O2 => D-maltobiono-1,5-lactone + H2O2"}
{"X":56923,"RHEA_ID":56728,"compounds":"4-hydroxy-all-trans-beta-carotene + AH2 + O2 = 4,4-dihydroxy-all-trans-beta-carotene + A + H2O"}
{"X":56924,"RHEA_ID":60136,"compounds":"a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2 = a (8S,9R)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate"}
{"X":56925,"RHEA_ID":56005,"DIRECTION":"LR","MASTER_ID":56004,"metacyc":"RXN-18909","compounds":"H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) => beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3)"}
{"X":56926,"RHEA_ID":56006,"compounds":"beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3)"}
{"X":56927,"RHEA_ID":56732,"compounds":"4,4-dihydroxy-all-trans-beta-carotene = echinenone + H2O"}
{"X":56928,"RHEA_ID":60608,"compounds":"1-tetradecanoyl-sn-glycero-3-phosphoethanolamine = 1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + ethanolamine"}
{"X":56929,"RHEA_ID":59353,"compounds":"beta-lactose + O2 => H2O2 + lactobiono-1,5-lactone"}
{"X":56930,"RHEA_ID":61912,"compounds":"ATP + H2O + voriconazole(in) = ADP + H(+) + phosphate + voriconazole(out)"}
{"X":56931,"RHEA_ID":58959,"compounds":"a ribonucleotide in RNA + S-adenosyl-L-methionine <=> a 2'-O-methylribonucleotide in RNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":56932,"RHEA_ID":60144,"compounds":"ATP + L-glutamate + L-glutamyl-[protein] = ADP + H(+) + L-gamma-glutamyl-L-glutamyl-[protein] + phosphate"}
{"X":56933,"RHEA_ID":61427,"compounds":"cis-cis-nepetalactol + NAD(+) <=> cis-cis-nepetalactone + H(+) + NADH"}
{"X":56934,"RHEA_ID":59358,"compounds":"H(+) + lactobionate => H2O + lactobiono-1,5-lactone"}
{"X":56935,"RHEA_ID":57849,"DIRECTION":"LR","MASTER_ID":57848,"metacyc":"RXN-20027","compounds":"2-oxoglutarate + O2 + scopoletin => CO2 + fraxetin + succinate"}
{"X":56936,"RHEA_ID":61429,"DIRECTION":"LR","MASTER_ID":61428,"metacyc":"RXN-20747","compounds":"cis-trans-nepetalactol + NAD(+) => cis-trans-nepetalactone + H(+) + NADH"}
{"X":56937,"RHEA_ID":55617,"compounds":"a carotenoid psi-end group => a carotenoid epsilon-end group"}
{"X":56938,"RHEA_ID":60151,"compounds":"(L-glutamyl)n-L-gamma-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate <=> (L-glutamyl)n+1-L-gamma-glutamyl-L-glutamyl-[protein] + ADP + H(+) + phosphate"}
{"X":56939,"RHEA_ID":56380,"DIRECTION":"UN","MASTER_ID":56380,"ec":"1.14.19.56","compounds":"(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 chloride + 2 FADH2 + 2 O2 = (4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 FAD + 4 H2O"}
{"X":56940,"RHEA_ID":60152,"compounds":"H2O + L-gamma-glutamyl-L-glutamyl-[protein] = L-glutamate + L-glutamyl-[protein]"}
{"X":56941,"RHEA_ID":61433,"compounds":"(R)-8-oxocitronellyl enol + NADP(+) => (6E)-8-oxogeranial + H(+) + NADPH"}
{"X":56942,"RHEA_ID":60287,"compounds":"N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":56943,"RHEA_ID":56384,"compounds":"(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2 = (5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O"}
{"X":56944,"RHEA_ID":60156,"DIRECTION":"UN","MASTER_ID":60156,"ec":"7.5.2.11","compounds":"ATP + D-galactose(out) + H2O = ADP + D-galactose(in) + H(+) + phosphate"}
{"X":56945,"RHEA_ID":61074,"compounds":"(-)-(R)-19-O-acetyltabersonine + CoA => (-)-(R)-19-hydroxytabersonine + acetyl-CoA"}
{"X":56946,"RHEA_ID":60159,"compounds":"ATP + D-galactose(out) + H2O <=> ADP + D-galactose(in) + H(+) + phosphate"}
{"X":56947,"RHEA_ID":56752,"DIRECTION":"UN","MASTER_ID":56752,"ec":"1.14.15.36","compounds":"a 14alpha-methyl steroid + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] = a Delta(14) steroid + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":56948,"RHEA_ID":60160,"compounds":"ATP + H2O + vincristine(in) = ADP + H(+) + phosphate + vincristine(out)"}
{"X":56949,"RHEA_ID":55637,"DIRECTION":"LR","MASTER_ID":55636,"ecocyc":"RXN0-6435","metacyc":"RXN0-6435","compounds":"ATP + C-terminal L-cysteinyl-[HypE protein] + carbamoyl phosphate + H2O => AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + diphosphate + H(+) + phosphate"}
{"X":56950,"RHEA_ID":58978,"compounds":"3-oxopropanoate + H(+) + H2O2 => H2O + malonaldehyde + O2"}
{"X":56951,"RHEA_ID":58979,"compounds":"H2O + malonaldehyde + O2 <=> 3-oxopropanoate + H(+) + H2O2"}
{"X":56952,"RHEA_ID":56032,"compounds":"H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) = beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1)"}
{"X":56953,"RHEA_ID":59376,"DIRECTION":"UN","MASTER_ID":59376,"ec":"5.4.99.67","compounds":"4-amino-4-deoxychorismate = 4-amino-4-deoxyprephenate"}
{"X":56954,"RHEA_ID":57869,"DIRECTION":"LR","MASTER_ID":57868,"metacyc":"RXN-12963","compounds":"(E)-4-coumaroyl-CoA + 2-oxoglutarate + O2 => (E)-2,4-dihydroxycinnamoyl-CoA + CO2 + succinate"}
{"X":56955,"RHEA_ID":56760,"compounds":"24,25-dihydrolanosterol + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] = 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":56956,"RHEA_ID":60181,"compounds":"ATP + D-fructose(out) + H2O => ADP + D-fructose(in) + H(+) + phosphate"}
{"X":56957,"RHEA_ID":61451,"compounds":"H(+) + NADPH + O2 + tigecycline <=> 11a-hydroxytigecycline + H2O + NADP(+)"}
{"X":56958,"RHEA_ID":57873,"DIRECTION":"LR","MASTER_ID":57872,"metacyc":"RXN-12350","compounds":"(E)-2,4-dihydroxycinnamoyl-CoA => CoA + umbelliferone"}
{"X":56959,"RHEA_ID":59784,"compounds":"H2O + NADP(+) + pseudopaline = (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADPH"}
{"X":56960,"RHEA_ID":61941,"compounds":"3beta-hydroxy-16alpha,17alpha-epoxypregnenolone + UDP-alpha-D-glucose => 3beta-hydroxy-16alpha,17alpha-epoxypregnenolone 3-beta-D-glucoside + H(+) + UDP"}
{"X":56961,"RHEA_ID":58611,"compounds":"2 L-ascorbate + N-decanoylglycine + O2 <=> H2O + 2 monodehydro-L-ascorbate radical + N-decanoyl-(2S)-hydroxyglycine"}
{"X":56962,"RHEA_ID":59385,"compounds":"2-oxoglutarate + 4-amino-L-phenylalanine => 3-(4-aminophenyl)pyruvate + L-glutamate"}
{"X":56963,"RHEA_ID":56768,"DIRECTION":"UN","MASTER_ID":56768,"ec":"1.14.99.64","compounds":"2 AH2 + all-trans-zeaxanthin + 2 O2 = 2 A + all-trans-adonixanthin + 3 H2O"}
{"X":56964,"RHEA_ID":59789,"compounds":"H2O + NAD(+) + pseudopaline => (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADH"}
{"X":56965,"RHEA_ID":57508,"DIRECTION":"UN","MASTER_ID":57508,"ec":"1.5.1.52","compounds":"H2O + NADP(+) + staphylopine = (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate"}
{"X":56966,"RHEA_ID":55654,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O"}
{"X":56967,"RHEA_ID":61461,"compounds":"a cytidine in RNA + S-adenosyl-L-methionine => a 5-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":56968,"RHEA_ID":56773,"DIRECTION":"LR","MASTER_ID":56772,"metacyc":"RXN-8190","compounds":"2 AH2 + all-trans-adonixanthin + 2 O2 => 2 A + all-trans-(3S,3'S)-astaxanthin + 3 H2O"}
{"X":56969,"RHEA_ID":58997,"compounds":"H2O + indole-3-carbaldehyde + O2 => H(+) + H2O2 + indole-3-carboxylate"}
{"X":56970,"RHEA_ID":58998,"compounds":"H(+) + H2O2 + indole-3-carboxylate => H2O + indole-3-carbaldehyde + O2"}
{"X":56971,"RHEA_ID":56776,"DIRECTION":"UN","MASTER_ID":56776,"ec":"1.14.19.74","compounds":"(+)-pinoresinol + O2 + reduced [NADPH--hemoprotein reductase] = (+)-piperitol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":56972,"RHEA_ID":60196,"compounds":"2-oxoglutarate + N(6)-methyl-L-lysyl(9)-[histone H3] + O2 = CO2 + formaldehyde + L-lysyl(9)-[histone H3] + succinate"}
{"X":56973,"RHEA_ID":60657,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-sn-glycero-2,3-cyclic phosphate + choline"}
{"X":56974,"RHEA_ID":57889,"compounds":"a quinone + 5 H(+)(in) + NADH => a quinol + 4 H(+)(out) + NAD(+)"}
{"X":56975,"RHEA_ID":56780,"DIRECTION":"UN","MASTER_ID":56780,"ec":"1.14.19.74","compounds":"(+)-piperitol + O2 + reduced [NADPH--hemoprotein reductase] = (+)-sesamin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":56976,"RHEA_ID":55664,"DIRECTION":"UN","MASTER_ID":55664,"ec":"1.14.99.63","compounds":"2 AH2 + echinenone + 2 O2 = 2 A + canthaxanthin + 3 H2O"}
{"X":56977,"RHEA_ID":59005,"compounds":"dodecanal + H2O + O2 => dodecanoate + H(+) + H2O2"}
{"X":56978,"RHEA_ID":55666,"compounds":"2 A + canthaxanthin + 3 H2O => 2 AH2 + echinenone + 2 O2"}
{"X":56979,"RHEA_ID":57894,"compounds":"a quinol + 4 H(+)(out) + NADP(+) => a quinone + 5 H(+)(in) + NADPH"}
{"X":56980,"RHEA_ID":61473,"compounds":"a sphingoid base + hexadecanoyl-CoA => an N-hexadecanoyl-sphingoid base + CoA + H(+)"}
{"X":56981,"RHEA_ID":60206,"compounds":"CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + O2"}
{"X":56982,"RHEA_ID":55670,"compounds":"11-cis-retinal--[retinol-binding protein] + H(+) + NADH => 11-cis-retinol--[retinol-binding protein] + NAD(+)"}
{"X":56983,"RHEA_ID":59011,"compounds":"H2O + O2 + salicylaldehyde <=> H(+) + H2O2 + salicylate"}
{"X":56984,"RHEA_ID":60669,"compounds":"(R,R)-chrysanthemol + NAD(+) => (1R,3R)-chrysanthemal + H(+) + NADH"}
{"X":56985,"RHEA_ID":59408,"compounds":"H2O + N-acetyl-L-aspartate = acetate + L-aspartate"}
{"X":56986,"RHEA_ID":58264,"compounds":"a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = an N-acylsphing-4-enine + cholesteryl 3-beta-D-glucoside"}
{"X":56987,"RHEA_ID":60212,"compounds":"2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + O2 = CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + succinate"}
{"X":56988,"RHEA_ID":59016,"DIRECTION":"UN","MASTER_ID":59016,"ec":"1.1.1.418","compounds":"4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + NAD(+) = CO2 + cycloeucalenone + NADH"}
{"X":56989,"RHEA_ID":60214,"compounds":"CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + O2"}
{"X":56990,"RHEA_ID":55690,"compounds":"1D-myo-inositol 1-phosphate + an N-acyl-(4R)-4-hydroxysphinganine + H(+) => an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + H2O"}
{"X":56991,"RHEA_ID":56796,"compounds":"[corrinoid adenosyltransferase]-cob(I)alamin + ATP = adenosylcob(III)alamin + apo-[corrinoid adenosyltransferase] + triphosphate"}
{"X":56992,"RHEA_ID":59020,"compounds":"1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = (9Z,12Z)-octadecadienoate + di-(9Z,12Z)-octadecadienoylglycerol + H(+)"}
{"X":56993,"RHEA_ID":60218,"compounds":"CO2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + O2"}
{"X":56994,"RHEA_ID":60219,"compounds":"2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3] + succinate"}
{"X":56995,"RHEA_ID":55695,"compounds":"H2O + inositol phosphoceramide <=> 1D-myo-inositol 1-phosphate + H(+) + N-acyl-sphingoid base"}
{"X":56996,"RHEA_ID":59024,"compounds":"H2O + trihexadecanoylglycerol = dihexadecanoylglycerol + H(+) + hexadecanoate"}
{"X":56997,"RHEA_ID":59829,"DIRECTION":"LR","MASTER_ID":59828,"metacyc":"RXN-20698","compounds":"H2O + S-inosyl-L-homocysteine => inosine + L-homocysteine"}
{"X":56998,"RHEA_ID":60223,"compounds":"2-oxoglutarate + N(6)-methyl-L-lysyl(4)-[histone H3] + O2 <=> CO2 + formaldehyde + L-lysyl(4)-[histone H3] + succinate"}
{"X":56999,"RHEA_ID":59027,"compounds":"H2O + trihexadecanoylglycerol <=> dihexadecanoylglycerol + H(+) + hexadecanoate"}
{"X":57000,"RHEA_ID":59028,"compounds":"(Z)-24-ethylidenelophenol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}
{"X":57001,"RHEA_ID":59029,"DIRECTION":"LR","MASTER_ID":59028,"metacyc":"RXN-19723","compounds":"(Z)-24-ethylidenelophenol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}
{"X":57002,"RHEA_ID":55702,"compounds":"an N-acyl-(4R)-4-hydroxysphinganine + H(+) + mannosyldiinositol-1-phosphate => an inositol phosphomannosylinositol-1-phospho-N-acyl-(4R)-4-hydroxysphinganine + H2O"}
{"X":57003,"RHEA_ID":56444,"compounds":"1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate"}
{"X":57004,"RHEA_ID":58654,"compounds":"rifamycin SV para-naphthoquinone carboxamide => rifamycin SV ortho-naphthoquinone carboxamide"}
{"X":57005,"RHEA_ID":59836,"compounds":"H2O + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein] = 3-deoxyglucosone + L-lysyl-[protein] + phosphate"}
{"X":57006,"RHEA_ID":59436,"compounds":"4-amino-L-phenylalanine + ATP + holo-[peptidyl-carrier protein] = 4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AMP + diphosphate"}
{"X":57007,"RHEA_ID":57295,"compounds":"an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA + H2O <=> a guanosine in RNA + glycolate + H(+)"}
{"X":57008,"RHEA_ID":62365,"compounds":"FMNH2 + O2 + thymine => (Z)-2-methylureidoacrylate + FMN-N(5)-oxide + 2 H(+)"}
{"X":57009,"RHEA_ID":59440,"compounds":"(-)-dehydrodiconiferyl alcohol + H(+) + NADPH = (S)-isodihydrodehydrodiconiferyl alcohol + NADP(+)"}
{"X":57010,"RHEA_ID":60848,"compounds":"a 5'-end diphospho-guanosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] = a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + L-lysyl-[protein]"}
{"X":57011,"RHEA_ID":57178,"compounds":"N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein] => L-arginyl-[protein] + methylglyoxal"}
{"X":57012,"RHEA_ID":60696,"compounds":"(R)-lavandulyl diphosphate + H2O = (R)-lavandulol + diphosphate"}
{"X":57013,"RHEA_ID":59444,"compounds":"1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene + A = 1,1'-dihydroxy-3,4-didehydro-1,2-dihydrolycopene + AH2"}
{"X":57014,"RHEA_ID":59847,"compounds":"(+)-dehydrodiconiferyl alcohol + H(+) + NADPH <=> (R)-isodihydrodehydrodiconiferyl alcohol + NADP(+)"}
{"X":57015,"RHEA_ID":56820,"DIRECTION":"UN","MASTER_ID":56820,"ec":"1.14.99.61","compounds":"AH2 + cyclooctat-9-en-7-ol + O2 = A + cyclooctat-9-ene-5,7-diol + H2O"}
{"X":57016,"RHEA_ID":60240,"compounds":"2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + O2 = CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + succinate"}
{"X":57017,"RHEA_ID":60702,"compounds":"a 1-acyl-sn-glycero-2,3-cyclic phosphate + choline => a 1-acyl-sn-glycero-3-phosphocholine"}
{"X":57018,"RHEA_ID":56097,"compounds":"[protein]-C-terminal Gly-Gly + ATP + H(+) => [protein]-C-terminal Gly-Gly-AMP + diphosphate"}
{"X":57019,"RHEA_ID":60244,"DIRECTION":"UN","MASTER_ID":60244,"ec":"1.14.99.66","compounds":"2 A + 2 H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] = 2 AH2 + 2 formaldehyde + L-lysyl(4)-[histone H3]"}
{"X":57020,"RHEA_ID":59451,"compounds":"dodecan-1-ol + NADP(+) <=> dodecanal + H(+) + NADPH"}
{"X":57021,"RHEA_ID":59452,"compounds":"a long-chain primary fatty alcohol + NADP(+) = a long-chain fatty aldehyde + H(+) + NADPH"}
{"X":57022,"RHEA_ID":62004,"compounds":"an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc6S derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc6S derivative + GDP + H(+)"}
{"X":57023,"RHEA_ID":60248,"compounds":"A + H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] = AH2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3]"}
{"X":57024,"RHEA_ID":59052,"DIRECTION":"UN","MASTER_ID":59052,"ec":"4.1.1.116","compounds":"D-lysine + H(+) = cadaverine + CO2"}
{"X":57025,"RHEA_ID":59190,"compounds":"D-histidine => L-histidine"}
{"X":57026,"RHEA_ID":59191,"DIRECTION":"BI","MASTER_ID":59188,"metacyc":"RXN-19818","compounds":"L-histidine <=> D-histidine"}
{"X":57027,"RHEA_ID":61525,"compounds":"(8Z,11Z,14Z)-eicosatrienoate + O2 => (15S)-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate"}
{"X":57028,"RHEA_ID":57943,"compounds":"Fe-coproporphyrin III + H(+) + H2O2 <=> CO2 + 2 H2O + harderoheme III"}
{"X":57029,"RHEA_ID":61526,"compounds":"(15S)-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2"}
{"X":57030,"RHEA_ID":58311,"compounds":"25-substituted-cholesterol + beta-D-glucosyl-N-(15Z-tetracosenoyl)-sphing-4E-enine <=> 25-substituted-cholesteryl beta-D-glucoside + N-(15Z-tetracosenoyl)-sphing-4-enine"}
{"X":57031,"RHEA_ID":62012,"compounds":"cytidine(2499) in 23S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(2499) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":57032,"RHEA_ID":62013,"compounds":"cytidine(2499) in 23S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(2499) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":57033,"RHEA_ID":59464,"compounds":"NADP(+) + octadecan-1-ol = H(+) + NADPH + octadecanal"}
{"X":57034,"RHEA_ID":60258,"compounds":"AH2 + formaldehyde + L-lysyl(4)-[histone H3] => A + H2O + N(6)-methyl-L-lysyl(4)-[histone H3]"}
{"X":57035,"RHEA_ID":57578,"compounds":"H(+) + H2O + loganate + oxidized [NADPH--hemoprotein reductase] => 7-deoxyloganate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":57036,"RHEA_ID":60720,"compounds":"(E)-hept-2-enal + H2O + NADP(+) = (E)-hept-2-enoate + 2 H(+) + NADPH"}
{"X":57037,"RHEA_ID":62017,"compounds":"L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose => 3-O-(beta-D-xylosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP"}
{"X":57038,"RHEA_ID":61747,"compounds":"steviolbioside + UDP-alpha-D-glucose <=> stevioside + UDP"}
{"X":57039,"RHEA_ID":57206,"compounds":"N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein] => glyoxal + L-lysyl-[protein]"}
{"X":57040,"RHEA_ID":60724,"compounds":"dodecanal + H2O + NADP(+) = dodecanoate + 2 H(+) + NADPH"}
{"X":57041,"RHEA_ID":60266,"compounds":"H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine => L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine"}
{"X":57042,"RHEA_ID":57956,"DIRECTION":"UN","MASTER_ID":57956,"ec":"1.14.13.245","compounds":"dimethyl sulfoxide + H(+) + NADH + O2 = dimethyl sulfone + H2O + NAD(+)"}
{"X":57043,"RHEA_ID":58325,"compounds":"beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine + cholesterol => cholesteryl 3-beta-D-glucoside + N-(9Z-octadecenoyl)-sphing-4-enine"}
{"X":57044,"RHEA_ID":57211,"compounds":"glyoxal + L-cysteinyl-[protein] <=> S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein]"}
{"X":57045,"RHEA_ID":60728,"compounds":"citral + H2O + NADP(+) = 3,7-dimethylocta-2,6-dienoate + 2 H(+) + NADPH"}
{"X":57046,"RHEA_ID":59879,"compounds":"(indol-3-yl)butanoate + ATP + L-cysteine <=> (indol-3-yl)butanoyl-L-cysteine + AMP + diphosphate + H(+)"}
{"X":57047,"RHEA_ID":60732,"compounds":"H2O + NADP(+) + perillyl aldehyde = 2 H(+) + NADPH + perillate"}
{"X":57048,"RHEA_ID":59479,"compounds":"2 AH2 + 2 ATP + benzoate + L-phenylalanine <=> 2 A + 2 AMP + 2 diphosphate + H(+) + N-benzoyl-L-phenylalaninol"}
{"X":57049,"RHEA_ID":59484,"DIRECTION":"UN","MASTER_ID":59484,"ec":"1.20.2.1","compounds":"2 [Fe(III)cytochrome c] + arsenite + H2O = 2 [Fe(II)cytochrome c] + arsenate + 3 H(+)"}
{"X":57050,"RHEA_ID":62032,"compounds":"a 1,2-diacyl-sn-glycero-3-phosphoglycerol + H2O = a 2-acyl-sn-glycero-3-phosphoglycerol + a fatty acid + H(+)"}
{"X":57051,"RHEA_ID":60276,"DIRECTION":"UN","MASTER_ID":60276,"ec":"2.1.1.355","compounds":"L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine"}
{"X":57052,"RHEA_ID":60737,"compounds":"(2E,6E)-farnesal + H2O + NADP(+) => (2E,6E)-farnesoate + 2 H(+) + NADPH"}
{"X":57053,"RHEA_ID":61582,"DIRECTION":"RL","MASTER_ID":61580,"metacyc":"RXN-20421","compounds":"(5S)-5-hydroxycyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH => (3S)-3-hydroxycyclohexane-1-carbonyl-CoA + NADP(+)"}
{"X":57054,"RHEA_ID":60279,"compounds":"L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine"}
{"X":57055,"RHEA_ID":57971,"compounds":"germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8-epi-inunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":57056,"RHEA_ID":59492,"compounds":"(2E)-geranyl diphosphate + L-tryptophyl-[protein] = 3-geranyl-2S,3R-dihydro-N-cyclo-L-tryptophyl-[protein] + diphosphate"}
{"X":57057,"RHEA_ID":56499,"compounds":"gypsogenin + O2 + reduced [NADPH--hemoprotein reductase] <=> gypsogenate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":57058,"RHEA_ID":60283,"compounds":"L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":57059,"RHEA_ID":57975,"compounds":"8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> eupatolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":57060,"RHEA_ID":62043,"compounds":"H2O + N-(octanoyl)-sphing-4-enine-1-phosphate <=> N-octanoylsphing-4-enine + phosphate"}
{"X":57061,"RHEA_ID":59895,"compounds":"L-2-amino-4-chloropent-4-enoate <=> chloride + H(+) + L-propargylglycine"}
{"X":57062,"RHEA_ID":56988,"compounds":"germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":57063,"RHEA_ID":57979,"compounds":"(20S)-protopanaxadiol + UDP-alpha-D-glucose <=> (20S)-ginsenoside C-K + H(+) + UDP"}
{"X":57064,"RHEA_ID":58347,"compounds":"beta-D-glucosyl-(1->3)-O-lithocholate + H2O <=> D-glucose + lithocholate"}
{"X":57065,"RHEA_ID":62047,"compounds":"a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphoglycerol + H2O <=> (9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphoglycerol + H(+)"}
{"X":57066,"RHEA_ID":62049,"compounds":"an N-aryl-1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O => an N-aryl-1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate"}
{"X":57067,"RHEA_ID":59096,"DIRECTION":"UN","MASTER_ID":59096,"ec":"2.4.1.369","compounds":"monoglucosyl-enterobactin + UDP-alpha-D-glucose = diglucosyl-enterobactin + H(+) + UDP"}
{"X":57068,"RHEA_ID":56873,"compounds":"(S)-N-acetyl-1-phenylethylamine + H2O => (S)-1-phenylethylamine + acetate"}
{"X":57069,"RHEA_ID":56511,"compounds":"3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate <=> 3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H(+) + UDP"}
{"X":57070,"RHEA_ID":60295,"compounds":"L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine"}
{"X":57071,"RHEA_ID":59507,"compounds":"cholesterol + glycyl-L-cysteinyl-[protein] + H(+) <=> [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein]"}
{"X":57072,"RHEA_ID":58723,"compounds":"(S)-nicotine + NADPH + O2 <=> H2O + NADP(+) + trans-(S)-nicotine N(1')-oxide"}
{"X":57073,"RHEA_ID":56515,"compounds":"3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H2O <=> 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + phosphate"}
{"X":57074,"RHEA_ID":60760,"compounds":"(1R,3R)-pyrethroyl-CoA + (Z,S)-jasmololone = CoA + jasmolin II"}
{"X":57075,"RHEA_ID":59511,"compounds":"fumarate + L-cysteinyl-[protein] <=> S-(2-succinyl)-L-cysteinyl-[protein]"}
{"X":57076,"RHEA_ID":56518,"compounds":"2 CO2 + 4 H2O + heme b => Fe-coproporphyrin III + 2 H(+) + 2 H2O2"}
{"X":57077,"RHEA_ID":58360,"compounds":"2-oxoglutarate + L-lysyl-[protein] + O2 = (5S)-5-hydroxy-L-lysyl-[protein] + CO2 + succinate"}
{"X":57078,"RHEA_ID":60304,"compounds":"N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":57079,"RHEA_ID":59515,"compounds":"acetylsalicylate + L-seryl-[protein] <=> O-acetyl-L-seryl-[protein] + salicylate"}
{"X":57080,"RHEA_ID":60766,"compounds":"cinerin II + CoA => (1R,3R)-pyrethroyl-CoA + (Z,S)-cinerolone"}
{"X":57081,"RHEA_ID":59516,"compounds":"acetylsalicylate + L-lysyl-[protein] = H(+) + N(6)-acetyl-L-lysyl-[protein] + salicylate"}
{"X":57082,"RHEA_ID":57626,"compounds":"3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":57083,"RHEA_ID":55784,"compounds":"all-trans-4-oxoretinoate + UDP-alpha-D-glucuronate = all-trans-4-oxoretinoate 1-O-(beta-D-glucuronate) + UDP"}
{"X":57084,"RHEA_ID":59112,"DIRECTION":"UN","MASTER_ID":59112,"ec":"2.7.1.225","compounds":"ATP + L-serine = ADP + H(+) + O-phospho-L-serine"}
{"X":57085,"RHEA_ID":59520,"compounds":"ATP + butanoyl-CoA + hydrogencarbonate = (2S)-ethylmalonyl-CoA + ADP + H(+) + phosphate"}
{"X":57086,"RHEA_ID":60311,"compounds":"L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-homocysteine"}
{"X":57087,"RHEA_ID":58003,"compounds":"(20S)-ginsenoside Rh2 + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rg3 + H(+) + UDP"}
{"X":57088,"RHEA_ID":58739,"compounds":"5-methyl-UTP + H2O <=> 5-methyl-UMP + diphosphate + H(+)"}
{"X":57089,"RHEA_ID":56894,"compounds":"NADP(+) + UDP-beta-L-rhamnose => H(+) + NADPH + UDP-4-dehydro-beta-L-rhamnose"}
{"X":57090,"RHEA_ID":62073,"compounds":"D-galactose 6-phosphate + NADP(+) => 6-phospho-D-galactono-1,5-lactone + H(+) + NADPH"}
{"X":57091,"RHEA_ID":62545,"compounds":"2 [Fe(II)cytochrome c] + 3 H(+) + ouabagenin => 2 [Fe(III)cytochrome c] + dihydroouabagenin"}
{"X":57092,"RHEA_ID":56534,"compounds":"N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + phosphate => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine phosphate"}
{"X":57093,"RHEA_ID":57637,"compounds":"(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + ML-236A carboxylate => compactin carboxylate + holo-[2-methylbutanoate polyketide synthase]"}
{"X":57094,"RHEA_ID":60320,"DIRECTION":"UN","MASTER_ID":60320,"ec":"2.1.1.358","compounds":"N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":57095,"RHEA_ID":55796,"compounds":"H(+) + NADH + O2 + phenol = H2O + hydroquinone + NAD(+)"}
{"X":57096,"RHEA_ID":58011,"compounds":"(20S)-ginsenoside F1 + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rg1 + H(+) + UDP"}
{"X":57097,"RHEA_ID":56539,"compounds":"(12R)-hydroxy-(9Z)-octadecenoyl-CoA + 1,2-di-(12R-hydroxy-9Z-octadecenoyl)-sn-glycerol <=> 1,2,3-tri-(12R-hydroxy-9Z-octadecenoyl)-glycerol + CoA"}
{"X":57098,"RHEA_ID":56903,"compounds":"globoside GalGb4Cer + UDP-N-acetyl-alpha-D-glucosamine <=> globoside GlcNAc-(beta1->6)-GalGb4Cer + H(+) + UDP"}
{"X":57099,"RHEA_ID":61642,"compounds":"benzoyl-CoA + CO2 => H(+) + isophthalyl-CoA"}
{"X":57100,"RHEA_ID":58015,"compounds":"cyclic tetraadenylate <=> 2 5'-hydroxy-diadenylate 2',3'-cylic phosphate"}
{"X":57101,"RHEA_ID":60806,"compounds":"CO2 + gibberellin A17 + H(+) + succinate => 2-oxoglutarate + gibberellin A19 + O2"}
{"X":57102,"RHEA_ID":60328,"DIRECTION":"UN","MASTER_ID":60328,"ec":"2.1.1.360","compounds":"L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine"}
{"X":57103,"RHEA_ID":59539,"compounds":"ATP + butanoyl-CoA + hydrogencarbonate <=> (2R)-ethylmalonyl-CoA + ADP + H(+) + phosphate"}
{"X":57104,"RHEA_ID":59133,"DIRECTION":"LR","MASTER_ID":59132,"metacyc":"RXN-19823","compounds":"2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + 2-oxoglutarate + ATP => AMP + diphosphate + H(+) + staphyloferrin B"}
{"X":57105,"RHEA_ID":61647,"compounds":"2 [Fe(II)-cytochrome b5] + 2 H(+) + N(omega)-hydroxy-L-arginine <=> 2 [Fe(III)-cytochrome b5] + H2O + L-arginine"}
{"X":57106,"RHEA_ID":59541,"compounds":"(2R)-ethylmalonyl-CoA + H(+) => butanoyl-CoA + CO2"}
{"X":57107,"RHEA_ID":59136,"DIRECTION":"UN","MASTER_ID":59136,"ec":"6.3.2.58","compounds":"ATP + citrate + D-ornithine = AMP + diphosphate + H(+) + N(5)-[(S)-citryl]-D-ornithine"}
{"X":57108,"RHEA_ID":56913,"compounds":"(Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + H2O + NAD(+) => (E)-2-((N-methylformamido) methylene)succinate + 3 H(+) + NADH"}
{"X":57109,"RHEA_ID":60335,"compounds":"L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":57110,"RHEA_ID":62093,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-diphosphate + H2O => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + phosphate"}
{"X":57111,"RHEA_ID":56916,"compounds":"3beta-hydroxy-5alpha-androstan-17-one + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH"}
{"X":57112,"RHEA_ID":60830,"compounds":"a 5'-end diphospho-adenosine in mRNA + H(+) + phosphate => a 5'-end triphospho-adenosine in mRNA + H2O"}
{"X":57113,"RHEA_ID":59548,"compounds":"N,N',N''-triacetylchitotriose + O2 = H2O2 + N,N',N''-triacetylchitotriono-1,5-lactone"}
{"X":57114,"RHEA_ID":60340,"compounds":"N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":57115,"RHEA_ID":62098,"compounds":"2-(9Z-octadecenoyl)-glycerol + phosphate => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O"}
{"X":57116,"RHEA_ID":59551,"compounds":"N,N',N''-triacetylchitotriose + O2 <=> H2O2 + N,N',N''-triacetylchitotriono-1,5-lactone"}
{"X":57117,"RHEA_ID":56197,"DIRECTION":"LR","MASTER_ID":56196,"metacyc":"2.4.1.122-RXN","compounds":"3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-alpha-D-galactose => H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP"}
{"X":57118,"RHEA_ID":60344,"DIRECTION":"UN","MASTER_ID":60344,"ec":"2.1.1.361","compounds":"L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine"}
{"X":57119,"RHEA_ID":59555,"compounds":"N,N',N'',N'''-tetraacetylchitotetraose + O2 <=> H2O2 + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone"}
{"X":57120,"RHEA_ID":59165,"DIRECTION":"LR","MASTER_ID":59164,"metacyc":"RXN-18541","compounds":"ATP + hexadecanoate + holo-[(hydroxy)phthioceranic acid synthase] => AMP + diphosphate + hexadecanoyl-[(hydroxy)phthioceranic acid synthase]"}
{"X":57121,"RHEA_ID":59557,"compounds":"H2O + N,N'-diacetylchitobiono-1,5-lactone => H(+) + N,N'-diacetylchitobionate"}
{"X":57122,"RHEA_ID":60348,"DIRECTION":"UN","MASTER_ID":60348,"ec":"2.1.1.362","compounds":"N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine"}
{"X":57123,"RHEA_ID":59168,"DIRECTION":"UN","MASTER_ID":59168,"ec":"6.2.1.57","compounds":"ATP + holo-[(hydroxy)phthioceranic acid synthase] + octadecanoate = AMP + diphosphate + octadecanoyl-[(hydroxy)phthioceranic acid synthase]"}
{"X":57124,"RHEA_ID":56928,"compounds":"abieta-7,13-dien-18-al + O2 + reduced [NADPH--hemoprotein reductase] = abieta-7,13-dien-18-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":57125,"RHEA_ID":56566,"compounds":"3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-threonyl-[EGF-like domain protein] + H(+) + UDP => 3-O-(beta-D-glucosyl)-L-threonyl-[EGF-like domain protein] + UDP-alpha-D-xylose"}
{"X":57126,"RHEA_ID":62109,"compounds":"an acyl-CoA + sn-glycero-3-phosphoethanolamine => a monoacyl-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":57127,"RHEA_ID":62759,"compounds":"4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":57128,"RHEA_ID":60354,"compounds":"CO + H(+) + N-octanoylanthranilate => 2-heptyl-3-hydroxy-4(1H)-quinolone + O2"}
{"X":57129,"RHEA_ID":59565,"compounds":"H2O + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone => H(+) + N,N',N'',N'''-tetraacetylchitotetraonate"}
{"X":57130,"RHEA_ID":60516,"compounds":"L-tryptophan = D-tryptophan"}
{"X":57131,"RHEA_ID":59176,"DIRECTION":"UN","MASTER_ID":59176,"ec":"2.7.1.226","compounds":"ADP + L-serine = AMP + H(+) + O-phospho-L-serine"}
{"X":57132,"RHEA_ID":60358,"compounds":"anthranilate + H(+) + octanoate => H2O + N-octanoylanthranilate"}
{"X":57133,"RHEA_ID":59983,"compounds":"8-oxo-dGTP + H2O <=> 8-oxo-dGDP + H(+) + phosphate"}
{"X":57134,"RHEA_ID":59179,"compounds":"ADP + L-serine <=> AMP + H(+) + O-phospho-L-serine"}
{"X":57135,"RHEA_ID":56940,"compounds":"5-methylsulfanyl-D-ribulose 1-phosphate = 2-(methylthio)acetaldehyde + dihydroxyacetone phosphate"}
{"X":57136,"RHEA_ID":59181,"DIRECTION":"LR","MASTER_ID":59180,"metacyc":"RXN-19815","compounds":"5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O => 2 AMP + H(+)"}
{"X":57137,"RHEA_ID":58052,"DIRECTION":"UN","MASTER_ID":58052,"ec":"2.3.1.280","compounds":"(2-aminoethyl)phosphonate + acetyl-CoA = (2-acetamidoethyl)phosphonate + CoA + H(+)"}
{"X":57138,"RHEA_ID":60364,"compounds":"H(+)(out) + myo-inositol(out) = H(+)(in) + myo-inositol(in)"}
{"X":57139,"RHEA_ID":59184,"DIRECTION":"UN","MASTER_ID":59184,"ec":"3.7.1.24","compounds":"2,4-diacetylphloroglucinol + H2O = 2-acetylphloroglucinol + acetate"}
{"X":57140,"RHEA_ID":60365,"compounds":"H(+)(out) + myo-inositol(out) => H(+)(in) + myo-inositol(in)"}
{"X":57141,"RHEA_ID":59186,"compounds":"2-acetylphloroglucinol + acetate => 2,4-diacetylphloroglucinol + H2O"}
{"X":57142,"RHEA_ID":58057,"compounds":"hypotaurine + pyruvate => 2-sulfinoacetaldehyde + L-alanine"}
{"X":57143,"RHEA_ID":60861,"compounds":"a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-adenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":57144,"RHEA_ID":59188,"DIRECTION":"UN","MASTER_ID":59188,"ec":"5.1.1.24","compounds":"L-histidine = D-histidine"}
{"X":57145,"RHEA_ID":57438,"compounds":"acetaldehyde + catechol + H(+) + H2O + oxidized [NADH--hemoprotein reductase] => guaethol + O2 + reduced [NADH--hemoprotein reductase]"}
{"X":57146,"RHEA_ID":57939,"compounds":"H2O + isopyridoxal + NAD(+) <=> 5-pyridoxate + 2 H(+) + NADH"}
{"X":57147,"RHEA_ID":60373,"compounds":"D-fructose(out) => D-fructose(in)"}
{"X":57148,"RHEA_ID":59208,"compounds":"ATP + H(+) + octadecanoate = diphosphate + octadecanoyl-AMP"}
{"X":57149,"RHEA_ID":59584,"DIRECTION":"UN","MASTER_ID":59584,"ec":"6.3.2.11","compounds":"ATP + beta-alanine + L-lysine = ADP + beta-alanyl-L-lysine + H(+) + phosphate"}
{"X":57150,"RHEA_ID":55852,"compounds":"[(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA = [(2->6)-alpha-D-glucosyl-(1->4)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA"}
{"X":57151,"RHEA_ID":59213,"DIRECTION":"LR","MASTER_ID":59212,"metacyc":"RXN-18543","compounds":"holo-[(hydroxy)phthioceranic acid synthase] + octadecanoyl-AMP => AMP + H(+) + octadecanoyl-[(hydroxy)phthioceranic acid synthase]"}
{"X":57152,"RHEA_ID":58436,"compounds":"4-methylpentan-1-ol + NADP(+) = 4-methylpentanal + H(+) + NADPH"}
{"X":57153,"RHEA_ID":55856,"compounds":"all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-18-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":57154,"RHEA_ID":58071,"compounds":"O2 + trans-isoeugenol <=> acetaldehyde + vanillin"}
{"X":57155,"RHEA_ID":57325,"compounds":"acetyl-CoA + N-terminal L-glutamyl-L-glutamyl-L-glutamyl-[protein] => CoA + H(+) + N-terminal N-acetyl-L-glutamyl-L-glutamyl-L-glutamyl-[protein]"}
{"X":57156,"RHEA_ID":58562,"DIRECTION":"RL","MASTER_ID":58560,"metacyc":"RXN-19984","compounds":"15alpha-stemmadenine intermediate I + NADPH => 15alpha-stemmadenine intermediate II + NADP(+)"}
{"X":57157,"RHEA_ID":60385,"DIRECTION":"LR","MASTER_ID":60384,"ecocyc":"RXN-14477","metacyc":"RXN-14477","compounds":"enterobactin + H2O => N-(2,3-dihydroxybenzoyl)-L-serine trimer"}
{"X":57158,"RHEA_ID":59872,"compounds":"L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP"}
{"X":57159,"RHEA_ID":62148,"compounds":"dGTP + dTMP = dGDP + dTDP"}
{"X":57160,"RHEA_ID":60388,"DIRECTION":"UN","MASTER_ID":60388,"ec":"3.1.1.109","compounds":"Fe(III)-di(C-5-deoxy-beta-D-glucosyl)-enterobactin + H2O = Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+)"}
{"X":57161,"RHEA_ID":58078,"compounds":"(11Z)-eicosenoate + glycerol + H(+) => 1-(11Z-eicosenoyl)-glycerol + H2O"}
{"X":57162,"RHEA_ID":59225,"DIRECTION":"LR","MASTER_ID":59224,"metacyc":"RXN-20046","compounds":"all-trans-geranylgeranyl diphosphate => diphosphate + hydropyrene"}
{"X":57163,"RHEA_ID":57333,"compounds":"H2O + 3 O2 + 3 propionate 3-nitronate => 3 3-oxopropanoate + 3 H(+) + H2O2 + 2 nitrate + nitrite"}
{"X":57164,"RHEA_ID":60392,"DIRECTION":"UN","MASTER_ID":60392,"ec":"3.1.1.109","compounds":"Fe(III)-C-5-deoxy-beta-D-glucosyl-enterobactin + H2O = Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+)"}
{"X":57165,"RHEA_ID":60393,"DIRECTION":"LR","MASTER_ID":60392,"metacyc":"RXN-20022","compounds":"Fe(III)-C-5-deoxy-beta-D-glucosyl-enterobactin + H2O => Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+)"}
{"X":57166,"RHEA_ID":59229,"compounds":"6-sulfo-alpha-D-quinovose => 6-sulfo-beta-D-quinovose"}
{"X":57167,"RHEA_ID":56247,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] <=> 2-hexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl hexadecanoate + apo--[retinol-binding protein]"}
{"X":57168,"RHEA_ID":60396,"DIRECTION":"UN","MASTER_ID":60396,"ec":"3.1.1.109","compounds":"Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O = Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine"}
{"X":57169,"RHEA_ID":61761,"DIRECTION":"LR","MASTER_ID":61760,"metacyc":"RXN-13518","compounds":"rebaudioside B + UDP-alpha-D-glucose => rebaudioside A + UDP"}
{"X":57170,"RHEA_ID":58455,"compounds":"N-terminal N,N-dimethyl-L-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N,N-trimethyl-L-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":57171,"RHEA_ID":58088,"compounds":"1-(7Z,10Z,13Z,16Z-docosatetraenoyl)-glycerol + H2O = (7Z,10Z,13Z,16Z)-docosatetraenoate + glycerol + H(+)"}
{"X":57172,"RHEA_ID":59234,"compounds":"diphosphate + hydropyrenol => all-trans-geranylgeranyl diphosphate + H2O"}
{"X":57173,"RHEA_ID":60413,"DIRECTION":"LR","MASTER_ID":60412,"metacyc":"RXN-20007","compounds":"H2O + monoglucosyl-enterobactin => [N-(2,3-dihydroxybenzoyl)-L-seryl]2-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine + H(+)"}
{"X":57174,"RHEA_ID":61767,"compounds":"stevioside + UDP-alpha-D-glucose <=> H(+) + rebaudioside E + UDP"}
{"X":57175,"RHEA_ID":60280,"compounds":"L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":57176,"RHEA_ID":59360,"DIRECTION":"UN","MASTER_ID":59360,"ec":"3.4.13.5","compounds":"carnosine + H2O = beta-alanine + L-histidine"}
{"X":57177,"RHEA_ID":58461,"compounds":"an acyl-CoA + sn-glycerol 3-phosphocholine => a monoacyl-sn-glycero-3-phosphocholine + CoA"}
{"X":57178,"RHEA_ID":59623,"compounds":"H2O + N(2)-(4-aminobutanoyl)-L-lysine <=> 4-aminobutanoate + L-lysine"}
{"X":57179,"RHEA_ID":58837,"DIRECTION":"LR","MASTER_ID":58836,"metacyc":"RXN-11926","compounds":"24-methylenecycloartanol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":57180,"RHEA_ID":61590,"compounds":"ADP + amicoumacin A 2-phosphate + H(+) => amicoumacin A + ATP"}
{"X":57181,"RHEA_ID":59630,"compounds":"4-aminobutanoate + L-arginine => H2O + N(2)-(4-aminobutanoyl)-L-arginine"}
{"X":57182,"RHEA_ID":61776,"compounds":"rebaudioside D + UDP-alpha-D-glucose = H(+) + rebaudioside M + UDP"}
{"X":57183,"RHEA_ID":58101,"compounds":"1-(15Z-tetracosenoyl)-glycerol + H2O => (15Z)-tetracosenoate + glycerol + H(+)"}
{"X":57184,"RHEA_ID":59248,"DIRECTION":"UN","MASTER_ID":59248,"ec":"2.8.3.17","compounds":"(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + (E)-4-coumaroyl-CoA = (R)-3-(4-hydroxyphenyl)lactoyl-CoA + trans-4-coumarate"}
{"X":57185,"RHEA_ID":59634,"compounds":"D-xylobiono-1,5-lactone + H2O2 => D-xylobiose + O2"}
{"X":57186,"RHEA_ID":59249,"compounds":"(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + (E)-4-coumaroyl-CoA => (R)-3-(4-hydroxyphenyl)lactoyl-CoA + trans-4-coumarate"}
{"X":57187,"RHEA_ID":60040,"DIRECTION":"UN","MASTER_ID":60040,"ec":"3.5.1.133","compounds":"H2O + N(2)-[(2E)-3-methylhex-2-enoyl]-L-glutaminate = (2E)-3-methylhex-2-enoate + L-glutamine"}
{"X":57188,"RHEA_ID":60039,"compounds":"H2O + N(2)-(3-hydroxy-3-methylhexanoyl)-L-glutaminate <=> 3-hydroxy-3-methylhexanoate + L-glutamine"}
{"X":57189,"RHEA_ID":59372,"compounds":"1-hexadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + 10-hydroxyoctadecanoate + H(+)"}
{"X":57190,"RHEA_ID":56271,"compounds":"CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] <=> CMP + H(+) + N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]"}
{"X":57191,"RHEA_ID":60043,"compounds":"H2O + N(2)-[(2E)-3-methylhex-2-enoyl]-L-glutaminate <=> (2E)-3-methylhex-2-enoate + L-glutamine"}
{"X":57192,"RHEA_ID":60436,"DIRECTION":"UN","MASTER_ID":60436,"ec":"3.1.1.112","compounds":"3-methylbutyl acetate + H2O = 3-methylbutanol + acetate + H(+)"}
{"X":57193,"RHEA_ID":59257,"DIRECTION":"LR","MASTER_ID":59256,"ecocyc":"RXN0-6938","metacyc":"RXN0-6938","compounds":"Fe(III)-enterobactin + H2O => Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+)"}
{"X":57194,"RHEA_ID":57002,"compounds":"CoA + H(+) + N(beta)-acetylstreptothricin F => acetyl-CoA + streptothricin F"}
{"X":57195,"RHEA_ID":60047,"compounds":"beta-D-Gal-(1<->1')-Cer + UDP-alpha-D-galactose <=> alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer + H(+) + UDP"}
{"X":57196,"RHEA_ID":58113,"compounds":"1''-O-acetyl-ADP-alpha-D-ribose + H2O => acetate + ADP-D-ribose + H(+)"}
{"X":57197,"RHEA_ID":62686,"compounds":"H(+) + rubrofusarin + S-adenosyl-L-homocysteine => norrubrofusarin + S-adenosyl-L-methionine"}
{"X":57198,"RHEA_ID":60639,"compounds":"N-(dodecanoyl)-sphing-4-enine-1-phosphocholine <=> choline + N-dodecanoyl-sphing-4-enine-1,3-cyclic phosphate"}
{"X":57199,"RHEA_ID":58485,"compounds":"H2O + N-(acetyl)-sphing-4-enine => acetate + sphing-4-enine"}
{"X":57200,"RHEA_ID":59649,"compounds":"D-xylotriono-1,5-lactone + H2O => D-xylotrionate + H(+)"}
{"X":57201,"RHEA_ID":61334,"compounds":"ADP + H(+) + indoxyl sulfate(out) + phosphate => ATP + H2O + indoxyl sulfate(in)"}
{"X":57202,"RHEA_ID":59265,"DIRECTION":"LR","MASTER_ID":59264,"ecocyc":"RXN-20024","metacyc":"RXN-20024","compounds":"Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O => Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + N-(2,3-dihydroxybenzoyl)-L-serine"}
{"X":57203,"RHEA_ID":61819,"compounds":"16,17-didehydropregnenolone + UDP-alpha-D-glucose <=> 16,17-didehydropregnenolone 3-beta-D-glucoside + H(+) + UDP"}
{"X":57204,"RHEA_ID":60929,"compounds":"(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] => 17-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":57205,"RHEA_ID":60930,"compounds":"17-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":57206,"RHEA_ID":60931,"compounds":"(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 17-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":57207,"RHEA_ID":61823,"compounds":"3beta-hydroxy-5alpha-androstan-17-one + UDP-alpha-D-glucose <=> epiandrosterone 3-beta-D-glucoside + H(+) + UDP"}
{"X":57208,"RHEA_ID":57016,"compounds":"3,6-dichloro-2-methoxybenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,6-dichlorosalicylate + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":57209,"RHEA_ID":61827,"compounds":"pregnenolone + UDP-alpha-D-glucose <=> H(+) + pregnenolone 3-beta-D-glucoside + UDP"}
{"X":57210,"RHEA_ID":58496,"compounds":"choline + H(+) + NADH + O2 = glycolaldehyde + H2O + NAD(+) + trimethylamine"}
{"X":57211,"RHEA_ID":60463,"compounds":"(6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)"}
{"X":57212,"RHEA_ID":62714,"compounds":"H2O + NADP(+) + stemphyloxin I => betaenone C + H(+) + NADPH + O2"}
{"X":57213,"RHEA_ID":60466,"compounds":"2',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out) => 2',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in)"}
{"X":57214,"RHEA_ID":60939,"compounds":"an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an (omega-1)-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":57215,"RHEA_ID":61958,"compounds":"1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + A + 2 H2O => 1-O-octadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + AH2 + O2"}
{"X":57216,"RHEA_ID":60941,"compounds":"(9Z)-hexadecenoate + O2 + reduced [NADPH--hemoprotein reductase] => (9Z)-16-hydroxyhexadec-9-enoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":57217,"RHEA_ID":55937,"compounds":"all-trans-4-hydroxyretinol + NAD(+) => all-trans-4-hydroxyretinal + H(+) + NADH"}
{"X":57218,"RHEA_ID":58504,"compounds":"(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate = (3Z)-2-oxo-4-carboxy-3-hexenedioate"}
{"X":57219,"RHEA_ID":61835,"compounds":"(24R)-ethylcholest-5-en-3beta-ol + UDP-alpha-D-glucose <=> H(+) + sitosteryl 3-beta-D-glucoside + UDP"}
{"X":57220,"RHEA_ID":62720,"compounds":"3 H(+) + 3 NADPH + 3 O2 + probetaenone I = betaenone B + 3 H2O + 3 NADP(+)"}
{"X":57221,"RHEA_ID":58139,"compounds":"acetate + ATP + H(+) <=> acetyl-AMP + diphosphate"}
{"X":57222,"RHEA_ID":59286,"compounds":"D-glucose + N-octadecanoylsphing-4-enine => beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O"}
{"X":57223,"RHEA_ID":59287,"compounds":"beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O <=> D-glucose + N-octadecanoylsphing-4-enine"}
{"X":57224,"RHEA_ID":60075,"compounds":"4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADH + O2 <=> 4beta-hydroxymethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + H2O + NAD(+)"}
{"X":57225,"RHEA_ID":61358,"compounds":"ADP + H(+) + methotrexate(out) + phosphate => ATP + H2O + methotrexate(in)"}
{"X":57226,"RHEA_ID":58884,"compounds":"AH2 + alpha-N-dichloroacetyl-p-aminophenylserinol + 2 O2 = A + chloramphenicol + 2 H2O"}
{"X":57227,"RHEA_ID":59676,"compounds":"D-maltotetraose + O2 = D-maltotetraono-1,5-lactone + H2O2"}
{"X":57228,"RHEA_ID":59292,"compounds":"beta-D-galactosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O = D-galactose + N-octadecanoylsphing-4-enine"}
{"X":57229,"RHEA_ID":60081,"DIRECTION":"LR","MASTER_ID":60080,"metacyc":"RXN-20114","compounds":"4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADH + O2 => 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + H2O + NAD(+)"}
{"X":57230,"RHEA_ID":60482,"compounds":"c-di-UMP + 2 diphosphate => 2 UTP"}
{"X":57231,"RHEA_ID":58517,"compounds":"(19S)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] => 15alpha-stemmadenine intermediate I + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":57232,"RHEA_ID":55952,"compounds":"GDP-alpha-D-mannose + inositol phosphoceramide = a mannosylinositol-1-phospho-N-acyl-sphingoid base + GDP + H(+)"}
{"X":57233,"RHEA_ID":62226,"compounds":"(E)-ascladiol + NADP(+) => H(+) + NADPH + neopatulin"}
{"X":57234,"RHEA_ID":59297,"compounds":"an N-acylglycine + 2 L-ascorbate + O2 => an N-acyl-(2S)-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical"}
{"X":57235,"RHEA_ID":58521,"compounds":"(19S)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] => akuammicine + formate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":57236,"RHEA_ID":56680,"DIRECTION":"UN","MASTER_ID":56680,"ec":"1.14.15.27","compounds":"beta-dihydromenaquinone-9 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":57237,"RHEA_ID":59301,"compounds":"3'-phosphoadenylyl sulfate + firefly D-luciferin => adenosine 3',5'-bisphosphate + firefly D-sulfoluciferin + H(+)"}
{"X":57238,"RHEA_ID":57793,"compounds":"3,4-dinitrotoluene + NADH + O2 => 4-methyl-6-nitrocatechol + NAD(+) + nitrite"}
{"X":57239,"RHEA_ID":58157,"compounds":"ATP + H2O + 4 Na(+)(in) => ADP + H(+) + 4 Na(+)(out) + phosphate"}
{"X":57240,"RHEA_ID":59304,"compounds":"3'-phosphoadenylyl sulfate + firefly L-luciferin = adenosine 3',5'-bisphosphate + firefly L-sulfoluciferin + H(+)"}
{"X":57241,"RHEA_ID":61859,"compounds":"dehydroprobetaenone I + 3 H(+) + 3 NADPH + 3 O2 <=> betaenone C + 3 H2O + 3 NADP(+)"}
{"X":57242,"RHEA_ID":59305,"compounds":"3'-phosphoadenylyl sulfate + firefly L-luciferin => adenosine 3',5'-bisphosphate + firefly L-sulfoluciferin + H(+)"}
{"X":57243,"RHEA_ID":57798,"compounds":"4-methylcatechol + NAD(+) + nitrite => 4-nitrotoluene + NADH + O2"}
{"X":57244,"RHEA_ID":62757,"compounds":"4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":57245,"RHEA_ID":56447,"compounds":"1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate"}
{"X":57246,"RHEA_ID":62760,"compounds":"4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":57247,"RHEA_ID":59696,"compounds":"D-cellotetraono-1,5-lactone + H2O = D-cellotetraonate + H(+)"}
{"X":57248,"RHEA_ID":59839,"compounds":"H2O + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein] <=> 3-deoxyglucosone + L-lysyl-[protein] + phosphate"}
{"X":57249,"RHEA_ID":62241,"DIRECTION":"LR","MASTER_ID":62240,"metacyc":"RXN-19240","compounds":"a thymidine(6-4)cytidine in DNA => a thymine-cytidine dinucleotide in DNA"}
{"X":57250,"RHEA_ID":58168,"DIRECTION":"UN","MASTER_ID":58168,"ec":"4.2.3.199","compounds":"(2E,6E)-farnesyl diphosphate = (-)-5-epi-eremophilene + diphosphate"}
{"X":57251,"RHEA_ID":60520,"compounds":"2 H2O + L-cystine-bis-glycine = 2 glycine + L-cystine"}
{"X":57252,"RHEA_ID":62246,"compounds":"a cytidine-thymine dinucleotide in DNA => a cytidine(6-4)thymidine in DNA"}
{"X":57253,"RHEA_ID":55973,"DIRECTION":"LR","MASTER_ID":55972,"metacyc":"RXN-12363","compounds":"acetyl-CoA + ethanol => CoA + ethyl acetate"}
{"X":57254,"RHEA_ID":56698,"compounds":"(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate => D-ribulose 5-phosphate + L-tryptophan"}
{"X":57255,"RHEA_ID":57810,"compounds":"3-chlorocatechol + NAD(+) + nitrite => 1-chloro-3-nitrobenzene + NADH + O2"}
{"X":57256,"RHEA_ID":62250,"compounds":"chloroacetate + 2 H(+) + NADPH => chloroacetaldehyde + H2O + NADP(+)"}
{"X":57257,"RHEA_ID":60108,"DIRECTION":"UN","MASTER_ID":60108,"ec":"4.2.1.175","compounds":"(R)-3-(4-hydroxyphenyl)lactoyl-CoA = (E)-4-coumaroyl-CoA + H2O"}
{"X":57258,"RHEA_ID":59321,"compounds":"D-cellobiono-1,5-lactone + H2O => 4-O-beta-D-glucopyranosyl-D-gluconate + H(+)"}
{"X":57259,"RHEA_ID":60556,"compounds":"uridine(35) in tRNA(Tyr) = pseudouridine(35) in tRNA(Tyr)"}
{"X":57260,"RHEA_ID":61877,"compounds":"1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl-8-hydroperoxy-20-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate"}
{"X":57261,"RHEA_ID":55981,"DIRECTION":"LR","MASTER_ID":55980,"metacyc":"RXN-18555","compounds":"1,2-saturated acyl-CoA + an acyl-CoA + H2O => an (R)-2-alkyl-3-oxoalkanoate + 2 CoA + H(+)"}
{"X":57262,"RHEA_ID":60112,"DIRECTION":"UN","MASTER_ID":60112,"ec":"4.2.1.175","compounds":"(R)-3-(indol-3-yl)lactoyl-CoA = (E)-3-(indol-3-yl)acryloyl-CoA + H2O"}
{"X":57263,"RHEA_ID":62005,"compounds":"an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc6S derivative + GDP-beta-L-fucose => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc6S derivative + GDP + H(+)"}
{"X":57264,"RHEA_ID":56224,"DIRECTION":"UN","MASTER_ID":56224,"ec":"2.4.1.146","compounds":"3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-threonyl-[protein] + H(+) + UDP"}
{"X":57265,"RHEA_ID":62422,"compounds":"a fatty acid + CO2 + H2O => a (R)-2-hydroxy fatty acid + O2"}
{"X":57266,"RHEA_ID":58309,"compounds":"25-substituted-cholesterol + beta-D-glucosyl-N-(15Z-tetracosenoyl)-sphing-4E-enine => 25-substituted-cholesteryl beta-D-glucoside + N-(15Z-tetracosenoyl)-sphing-4-enine"}
{"X":57267,"RHEA_ID":57442,"compounds":"2-hydroxytoluene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] => 2-methylanisole + O2 + reduced [NADH--hemoprotein reductase]"}
{"X":57268,"RHEA_ID":57076,"compounds":"3-oxo-isoapionate 4-phosphate + H2O = 3-phosphoglycerate + glycolate + H(+)"}
{"X":57269,"RHEA_ID":60566,"compounds":"2-deoxy-D-glucose 6-phosphate + ADP + H(+) => 2-deoxy-D-glucose + ATP"}
{"X":57270,"RHEA_ID":59333,"compounds":"1'-hydroxy-gamma-carotene + A => 1'-hydroxytorulene + AH2"}
{"X":57271,"RHEA_ID":58682,"compounds":"AH2 + FAD + H(+) => A + FADH2"}
{"X":57272,"RHEA_ID":61889,"compounds":"diosgenin + UDP-alpha-D-glucose => diosgenin 3-beta-D-glucoside + H(+) + UDP"}
{"X":57273,"RHEA_ID":60570,"compounds":"N-acetyl-D-tryptophan => N-acetyl-L-tryptophan"}
{"X":57274,"RHEA_ID":59721,"compounds":"D-maltohexaono-1,5-lactone + H2O => D-maltohexaonate + H(+)"}
{"X":57275,"RHEA_ID":59724,"compounds":"D-maltoheptaono-1,5-lactone + H2O = D-maltoheptaonate + H(+)"}
{"X":57276,"RHEA_ID":61164,"compounds":"kaempferol + UDP-beta-L-rhamnose = H(+) + kaempferol 3-O-alpha-L-rhamnoside + UDP"}
{"X":57277,"RHEA_ID":62270,"compounds":"3-methyl-2-oxobutanoate + H(+) + NADPH => (R)-2-hydroxy-3-methylbutyrate + NADP(+)"}
{"X":57278,"RHEA_ID":60874,"compounds":"a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(7)-methylguanosine 5'-diphosphate => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O"}
{"X":57279,"RHEA_ID":59341,"compounds":"1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene + A => 1'-hydroxy-demethylspheroidene + AH2"}
{"X":57280,"RHEA_ID":58197,"DIRECTION":"LR","MASTER_ID":58196,"metacyc":"3.5.1.98-RXN","compounds":"H2O + N(6)-acetyl-L-lysyl-[histone] => acetate + L-lysyl-[histone]"}
{"X":57281,"RHEA_ID":56001,"DIRECTION":"LR","MASTER_ID":56000,"metacyc":"RXN-18908","compounds":"H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] => beta-D-glucose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3)"}
{"X":57282,"RHEA_ID":60582,"compounds":"18-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":57283,"RHEA_ID":57458,"compounds":"4-O-(beta-D-glucosyl)-trans-sinapate + H(+) + UDP => trans-sinapate + UDP-alpha-D-glucose"}
{"X":57284,"RHEA_ID":60604,"compounds":"1-tetradecanoyl-sn-glycero-3-phosphocholine = 1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + choline"}
{"X":57285,"RHEA_ID":62279,"compounds":"3 (R)-2-hydroxy-3-methylbutyrate + 6 ATP + 3 L-phenylalanine + 3 S-adenosyl-L-methionine <=> 6 AMP + beauvericin + 6 diphosphate + 6 H(+) + 3 S-adenosyl-L-homocysteine"}
{"X":57286,"RHEA_ID":62284,"compounds":"2 ATP + L-proline + L-tryptophan + NADPH = (8aS)-3-[(1H-indol-3-yl)methyl]-1H,2H,6H,7H,8H,8aH-pyrrolo[1,2-a]pyrazin-1-one + 2 AMP + 2 diphosphate + H(+) + H2O + NADP(+)"}
{"X":57287,"RHEA_ID":57095,"compounds":"AH2 + S-(methylsulfanyl)glutathione <=> A + glutathione + methanethiol"}
{"X":57288,"RHEA_ID":58574,"compounds":"H2O2 + precondylocarpine acetate => O-acetyl-15alpha-stemmadenine + O2"}
{"X":57289,"RHEA_ID":59738,"compounds":"CoA + S-tetradecanoyl-L-cysteinyl-[protein] => L-cysteinyl-[protein] + tetradecanoyl-CoA"}
{"X":57290,"RHEA_ID":61911,"compounds":"2 ATP + benzoate + L-phenylalanine + N-benzoyl-L-phenylalaninol <=> 2 AMP + asperphenamate + 2 diphosphate + H(+)"}
{"X":57291,"RHEA_ID":57099,"compounds":"1-methylsulfanyl-D-xylulose 5-phosphate + AH2 <=> 1-deoxy-D-xylulose 5-phosphate + A + methanethiol"}
{"X":57292,"RHEA_ID":60612,"compounds":"1-octanoyl-sn-glycero-3-phosphocholine = 1-octanoyl-sn-glycero-2,3-cyclic phosphate + choline"}
{"X":57293,"RHEA_ID":59357,"compounds":"H2O + lactobiono-1,5-lactone => H(+) + lactobionate"}
{"X":57294,"RHEA_ID":59743,"compounds":"L-cysteinyl-[protein] + octadecanoyl-CoA <=> CoA + S-octadecanoyl-L-cysteinyl-[protein]"}
{"X":57295,"RHEA_ID":59888,"compounds":"4-chloro-L-lysine + AH2 + O2 = A + formaldehyde + H2O + L-2-amino-4-chloropent-4-enoate + NH4(+)"}
{"X":57296,"RHEA_ID":61307,"compounds":"N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + UDP-alpha-D-glucose <=> H(+) + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + UDP"}
{"X":57297,"RHEA_ID":60742,"compounds":"(S)-(-)-citronellate + 2 H(+) + NADPH => (S)-(-)-citronellal + H2O + NADP(+)"}
{"X":57298,"RHEA_ID":58216,"compounds":"A + dihydroserpentine = AH2 + serpentine"}
{"X":57299,"RHEA_ID":57853,"compounds":"a pyrimidine 2'-deoxyribonucleoside 5'-phosphate + H2O => 2-deoxy-D-ribose 5-phosphate + a pyrimidine nucleobase"}
{"X":57300,"RHEA_ID":60620,"compounds":"N-hexanoyl-sphing-4-enine-1-phosphocholine = choline + N-(hexanoyl)-sphing-4-enine-1,3-cyclic phosphate"}
{"X":57301,"RHEA_ID":57474,"compounds":"1-O-(trans-4-coumaroyl)-beta-D-glucose + UDP => trans-4-coumarate + UDP-alpha-D-glucose"}
{"X":57302,"RHEA_ID":61191,"compounds":"quercetin 3-O-beta-D-glucoside + UDP-beta-L-rhamnose <=> H(+) + quercetin 3-O-beta-D-glucoside-7-O-alpha-L-rhamnoside + UDP"}
{"X":57303,"RHEA_ID":60749,"compounds":"(1R,3R)-pyrethroyl-CoA + (Z,S)-pyrethrolone => CoA + pyrethrin II"}
{"X":57304,"RHEA_ID":58590,"compounds":"(+)-vincadifformine + acetate + NADP(+) => dihydroprecondylocarpine acetate + NADPH"}
{"X":57305,"RHEA_ID":56507,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":57306,"RHEA_ID":62302,"compounds":"1-hydroxy-3-{[2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine + NADP(+) => 1-hydroxy-3-{[2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl]methyl}-6H,7H,8H-5lambda5-pyrrolo[1,2-a]pyrazine + H(+) + NADPH"}
{"X":57307,"RHEA_ID":57114,"compounds":"1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}
{"X":57308,"RHEA_ID":60628,"compounds":"AH2 + gluconapin + O2 = A + H2O + xi-progoitrin"}
{"X":57309,"RHEA_ID":56029,"DIRECTION":"LR","MASTER_ID":56028,"metacyc":"RXN-18910","compounds":"3 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) => 3 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)"}
{"X":57310,"RHEA_ID":57238,"compounds":"N(2)-(1-hydroxy-2-oxopropyl)-GMP => GMP + methylglyoxal"}
{"X":57311,"RHEA_ID":57865,"DIRECTION":"LR","MASTER_ID":57864,"metacyc":"RXN-20040","compounds":"indole-3-carbonyl nitrile + O2 + reduced [NADPH--hemoprotein reductase] => 4-hydroxy-indole-3-carbonyl nitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":57312,"RHEA_ID":59769,"compounds":"hexadecanoyl-CoA + L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein] => CoA + H(+) + N(6)-hexadecanoyl-L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein]"}
{"X":57313,"RHEA_ID":60632,"compounds":"all-trans-4-oxoretinol + NAD(+) = all-trans-4-oxoretinal + H(+) + NADH"}
{"X":57314,"RHEA_ID":62310,"compounds":"(+)-malbrancheamide B + FADH2 => (+)-premalbrancheamide + chloride + FAD + 2 H(+)"}
{"X":57315,"RHEA_ID":57122,"compounds":"1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}
{"X":57316,"RHEA_ID":60636,"compounds":"N-(dodecanoyl)-sphing-4-enine-1-phosphocholine = choline + N-dodecanoyl-sphing-4-enine-1,3-cyclic phosphate"}
{"X":57317,"RHEA_ID":56037,"DIRECTION":"LR","MASTER_ID":56036,"metacyc":"RXN-18929","compounds":"H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1) => beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3)"}
{"X":57318,"RHEA_ID":59381,"DIRECTION":"LR","MASTER_ID":59380,"metacyc":"RXN-20193","compounds":"4-amino-4-deoxyprephenate + NAD(+) => 3-(4-aminophenyl)pyruvate + CO2 + H(+) + NADH"}
{"X":57319,"RHEA_ID":60303,"compounds":"N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":57320,"RHEA_ID":56401,"compounds":"[(3R)-hydroxybutanoate](n) + H2O => (3R)-hydroxybutanoate tetramer + [(3R)-hydroxybutanoate](n-4) + H(+)"}
{"X":57321,"RHEA_ID":57503,"compounds":"3-hydroxybutane-1,2,3-tricarboxylate <=> 2-methyl-cis-aconitate + H2O"}
{"X":57322,"RHEA_ID":58239,"compounds":"L-tyrosyl-[protein] + NAD(+) <=> H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-tyrosyl-[protein]"}
{"X":57323,"RHEA_ID":57130,"compounds":"(4-hydroxyphenyl)acetaldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin] => H2O + 2 oxidized [azurin] + tyramine"}
{"X":57324,"RHEA_ID":61944,"compounds":"24-methylenecholesterol + UDP-alpha-D-glucose = 24-methylene cholesteryl beta-D-glucoside + H(+) + UDP"}
{"X":57325,"RHEA_ID":60188,"DIRECTION":"UN","MASTER_ID":60188,"ec":"1.14.11.65","compounds":"2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + L-lysyl(9)-[histone H3] + 2 succinate"}
{"X":57326,"RHEA_ID":61096,"compounds":"(S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] = (S)-eriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":57327,"RHEA_ID":60653,"compounds":"an N-(acyl)-sphingosylphosphocholine => an N-(acyl)-sphingosyl-1,3-cyclic phosphate + choline"}
{"X":57328,"RHEA_ID":56049,"DIRECTION":"LR","MASTER_ID":56048,"metacyc":"RXN-3584","compounds":"daidzein + UDP-alpha-D-glucose => daidzein 7-O-beta-D-glucoside + UDP"}
{"X":57329,"RHEA_ID":60194,"compounds":"CO2 + formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + O2"}
{"X":57330,"RHEA_ID":59796,"compounds":"dodecanoyl-CoA + L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein] = CoA + H(+) + N(6)-dodecanoyl-L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein]"}
{"X":57331,"RHEA_ID":60656,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-sn-glycero-2,3-cyclic phosphate + choline"}
{"X":57332,"RHEA_ID":62329,"compounds":"(+)-isomalbrancheamide B + chloride + FAD + 2 H(+) => (+)-malbrancheamide + FADH2"}
{"X":57333,"RHEA_ID":59396,"compounds":"L-leucine = D-leucine"}
{"X":57334,"RHEA_ID":57142,"compounds":"1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine"}
{"X":57335,"RHEA_ID":58379,"compounds":"decan-1-ol + NADP(+) <=> decanal + H(+) + NADPH"}
{"X":57336,"RHEA_ID":59400,"compounds":"L-2-aminohexanoate = D-2-aminohexanoate"}
{"X":57337,"RHEA_ID":58256,"compounds":"H2O + O-(ADP-D-ribosyl)-L-seryl-[protein] = ADP-D-ribose + L-seryl-[protein]"}
{"X":57338,"RHEA_ID":61108,"compounds":"(2R,3R)-dihydrokaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (2R,3R)-dihydromyricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":57339,"RHEA_ID":57523,"compounds":"15,16-epoxydolabrene + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta-hydroxy-15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":57340,"RHEA_ID":59404,"compounds":"L-homoserine = D-homoserine"}
{"X":57341,"RHEA_ID":59807,"compounds":"L-phenylalanine <=> D-phenylalanine"}
{"X":57342,"RHEA_ID":57150,"compounds":"1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine"}
{"X":57343,"RHEA_ID":57527,"compounds":"a 5'-triphospho-guanosine-ribonucleotide-tRNA(His) + H2O <=> a 5'-phospho-guanosine-ribonucleotide-tRNA(His) + diphosphate + H(+)"}
{"X":57344,"RHEA_ID":56426,"compounds":"(9Z,12Z)-octadecadienoate + H(+) + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine => H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine"}
{"X":57345,"RHEA_ID":59811,"compounds":"L-tyrosine <=> D-tyrosine"}
{"X":57346,"RHEA_ID":56066,"compounds":"3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP => 3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose"}
{"X":57347,"RHEA_ID":61970,"compounds":"A + a 1-O-(1Z,9Z-octadecadienyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 H2O => a 1-O-(9Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + AH2 + O2"}
{"X":57348,"RHEA_ID":59412,"DIRECTION":"UN","MASTER_ID":59412,"ec":"3.5.1.3","compounds":"2-oxosuccinamate + H2O = NH4(+) + oxaloacetate"}
{"X":57349,"RHEA_ID":59814,"compounds":"CoA + H(+) + N-terminal N(6)-hexadecanoylglycyl-[protein] => hexadecanoyl-CoA + N-terminal glycyl-[protein]"}
{"X":57350,"RHEA_ID":58269,"compounds":"[protein]-C-terminal glycine + NAD(+) => [protein]-C-terminal O-(ADP-D-ribosyl)-glycine + nicotinamide"}
{"X":57351,"RHEA_ID":61974,"compounds":"1-O-(1Z-13-methyltetradecenyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + A + 2 H2O => 1-O-(13-methyltetradecyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + AH2 + O2"}
{"X":57352,"RHEA_ID":59416,"compounds":"H2O + O2 + tryptamine = H2O2 + indole-3-acetaldehyde + NH4(+)"}
{"X":57353,"RHEA_ID":59417,"compounds":"H2O + O2 + tryptamine => H2O2 + indole-3-acetaldehyde + NH4(+)"}
{"X":57354,"RHEA_ID":57538,"compounds":"5'-NTP-ribonucleotide-RNA + AMP + H(+) => a ribonucleoside 5'-triphosphate + adenosine-5'-diphospho-5'-ribonucleotide-RNA"}
{"X":57355,"RHEA_ID":61977,"compounds":"glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine => 5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin]"}
{"X":57356,"RHEA_ID":59023,"compounds":"1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O <=> (9Z,12Z)-octadecadienoate + di-(9Z,12Z)-octadecadienoylglycerol + H(+)"}
{"X":57357,"RHEA_ID":59421,"compounds":"H2O + methylamine + O2 => formaldehyde + H2O2 + NH4(+)"}
{"X":57358,"RHEA_ID":57166,"compounds":"(3R)-3-hydroxy-L-arginyl-[RCC1 domain-containing protein] + CO2 + succinate => 2-oxoglutarate + L-arginyl-[RCC1 domain-containing protein] + O2"}
{"X":57359,"RHEA_ID":61982,"compounds":"NADP(+) + ubiquinol-10 => H(+) + NADPH + ubiquinone-10"}
{"X":57360,"RHEA_ID":57544,"DIRECTION":"UN","MASTER_ID":57544,"ec":"1.14.14.160","compounds":"(S)-beta-macrocarpene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + zealexin A1"}
{"X":57361,"RHEA_ID":56081,"compounds":"[Rab1 protein]-L-serine + CDP-choline => [Rab1 protein]-O-phosphocholine-L-serine + CMP + H(+)"}
{"X":57362,"RHEA_ID":60227,"compounds":"2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 2 O2 <=> 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + 2 succinate"}
{"X":57363,"RHEA_ID":61497,"DIRECTION":"LR","MASTER_ID":61496,"metacyc":"RXN3O-663","compounds":"an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose => a mannosylinositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base + GDP + H(+)"}
{"X":57364,"RHEA_ID":59425,"DIRECTION":"LR","MASTER_ID":59424,"metacyc":"RXN-18951","reactome":"R-HSA-5696183.1","compounds":"benzylamine + H2O + O2 => benzaldehyde + H2O2 + NH4(+)"}
{"X":57365,"RHEA_ID":62589,"compounds":"2-hydroxy-2-(4-hydroxyphenyl)acetate + H(+) => 4-hydroxybenzyl alcohol + CO2"}
{"X":57366,"RHEA_ID":59975,"compounds":"decanoyl-CoA + L-seryl-[protein] <=> CoA + O-decanoyl-L-seryl-[protein]"}
{"X":57367,"RHEA_ID":62758,"compounds":"4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O => 4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}
{"X":57368,"RHEA_ID":56570,"compounds":"globoside IV3GalNAc-Gb4Cer + H(+) + UDP => globoside Gb4Cer + UDP-N-acetyl-alpha-D-galactosamine"}
{"X":57369,"RHEA_ID":62593,"compounds":"(S)-8-oxocitronellyl enol + NADP(+) => (6E)-8-oxogeranial + H(+) + NADPH"}
{"X":57370,"RHEA_ID":59844,"compounds":"(+)-dehydrodiconiferyl alcohol + H(+) + NADPH = (R)-isodihydrodehydrodiconiferyl alcohol + NADP(+)"}
{"X":57371,"RHEA_ID":59845,"compounds":"(+)-dehydrodiconiferyl alcohol + H(+) + NADPH => (R)-isodihydrodehydrodiconiferyl alcohol + NADP(+)"}
{"X":57372,"RHEA_ID":56454,"compounds":"12-epi-hapalindole U => 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole"}
{"X":57373,"RHEA_ID":58295,"compounds":"25-substituted-cholesterol + beta-D-glucosyl-N-dodecanoylsphing-4E-enine <=> 25-substituted-cholesteryl beta-D-glucoside + N-dodecanoylsphing-4-enine"}
{"X":57374,"RHEA_ID":58297,"compounds":"25-substituted-cholesterol + beta-D-glucosyl-N-hexadecanoylsphing-4E-enine => 25-substituted-cholesteryl beta-D-glucoside + N-hexadecanoylsphing-4-enine"}
{"X":57375,"RHEA_ID":57183,"compounds":"L-lysyl-[protein] + methylglyoxal <=> N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein]"}
{"X":57376,"RHEA_ID":60700,"compounds":"a 1-acyl-sn-glycero-3-phosphocholine = a 1-acyl-sn-glycero-2,3-cyclic phosphate + choline"}
{"X":57377,"RHEA_ID":59851,"compounds":"(2R,3S)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH <=> (S)-tetrahydrodehydrodiconiferyl alcohol + NADP(+)"}
{"X":57378,"RHEA_ID":57186,"compounds":"S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein] => L-cysteinyl-[protein] + methylglyoxal"}
{"X":57379,"RHEA_ID":58670,"compounds":"3-deoxyglucosone + H(+) + NADPH => 3-deoxyfructose + NADP(+)"}
{"X":57380,"RHEA_ID":61150,"compounds":"H(+) + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] + UDP => myricetin 3-O-alpha-L-rhamnoside + UDP-alpha-D-glucose"}
{"X":57381,"RHEA_ID":62420,"compounds":"a (R)-2-hydroxy fatty acid + O2 = a fatty acid + CO2 + H2O"}
{"X":57382,"RHEA_ID":59856,"DIRECTION":"UN","MASTER_ID":59856,"ec":"2.1.1.252","compounds":"[Co(I) tetramethylammonium-specific corrinoid protein] + H(+) + tetramethylammonium = [methyl-Co(III) tetramethylammonium-specific corrinoid protein] + trimethylamine"}
{"X":57383,"RHEA_ID":58427,"compounds":"(E)-hex-2-en-1-ol + NADP(+) <=> (E)-2-hexenal + H(+) + NADPH"}
{"X":57384,"RHEA_ID":62780,"compounds":"4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}
{"X":57385,"RHEA_ID":62609,"compounds":"glutathione + H(+) + hydrogen sulfide + ubiquinone-10 => S-sulfanylglutathione + ubiquinol-10"}
{"X":57386,"RHEA_ID":58061,"compounds":"2-sulfinoacetaldehyde + H2O => acetaldehyde + H(+) + sulfite"}
{"X":57387,"RHEA_ID":60712,"compounds":"(+)-artemisinic alcohol + NAD(+) = (+)-artemisinic aldehyde + H(+) + NADH"}
{"X":57388,"RHEA_ID":60714,"compounds":"(+)-artemisinic aldehyde + H(+) + NADH => (+)-artemisinic alcohol + NAD(+)"}
{"X":57389,"RHEA_ID":62433,"DIRECTION":"LR","MASTER_ID":62432,"metacyc":"RXN-21179","compounds":"a uridine in tRNA + S-adenosyl-L-methionine => a 3-[(3S)-3-amino-3-carboxypropyl]-uridine in tRNA + H(+) + S-methyl-5'-thioadenosine"}
{"X":57390,"RHEA_ID":61159,"compounds":"3'-dephospho-CoA + GTP <=> CoA + GDP + H(+)"}
{"X":57391,"RHEA_ID":60870,"compounds":"a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(7)-methylguanosine 5'-diphosphate => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O"}
{"X":57392,"RHEA_ID":62446,"compounds":"H(+) + L-arginine + L-canaline => L-canavanine + L-ornithine"}
{"X":57393,"RHEA_ID":57705,"compounds":"(2R)-3-(3,4-dihydroxyphenyl)lactate + NADP(+) => 3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADPH"}
{"X":57394,"RHEA_ID":61531,"compounds":"a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphingoid base <=> a diacylglycerol + an N-[omega-(9Z,12Z-octadecadienoyloxy)-O-ultra-long chain fatty acyl]-sphingoid base"}
{"X":57395,"RHEA_ID":58686,"compounds":"FADH2-C4alpha-hydroperoxide + NADP(+) => FAD + 2 H(+) + NADPH + O2"}
{"X":57396,"RHEA_ID":60007,"compounds":"(L-glutamyl)n+1-L-gamma-glutamyl-L-glutamyl-[protein] + H2O <=> (L-glutamyl)n-L-gamma-glutamyl-L-glutamyl-[protein] + L-glutamate"}
{"X":57397,"RHEA_ID":58440,"compounds":"N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N-terminal N,N,N-trimethyl-L-glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-homocysteine"}
{"X":57398,"RHEA_ID":61897,"compounds":"betaenone C => betaenone A"}
{"X":57399,"RHEA_ID":58690,"compounds":"H2O + NAD(+) + rifamycin SV para-naphthoquinone carboxamide => NADH + O2 + rifamycin SV"}
{"X":57400,"RHEA_ID":62474,"compounds":"1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-nonadioyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine"}
{"X":57401,"RHEA_ID":60012,"compounds":"a tRNA with a 3' CC end + ATP = a tRNA with a 3' CCA end + diphosphate"}
{"X":57402,"RHEA_ID":61293,"compounds":"(R)-pantoate + NAD(+) => 2-dehydropantoate + H(+) + NADH"}
{"X":57403,"RHEA_ID":62482,"compounds":"2-glutaroyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O"}
{"X":57404,"RHEA_ID":62024,"compounds":"campesteryl 3-beta-D-glucoside + H2O = campesterol + D-glucose"}
{"X":57405,"RHEA_ID":60729,"compounds":"citral + H2O + NADP(+) => 3,7-dimethylocta-2,6-dienoate + 2 H(+) + NADPH"}
{"X":57406,"RHEA_ID":56488,"compounds":"O2 + oleanolate + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + hederagenin + oxidized [NADPH--hemoprotein reductase]"}
{"X":57407,"RHEA_ID":59881,"compounds":"4-hydroxyphenylacetate + FMNH2 + O2 => 3,4-dihydroxyphenylacetate + FMN + H(+) + H2O"}
{"X":57408,"RHEA_ID":61178,"compounds":"CoA + H(+) + quercetin 3-O-[(6-O-[(E)-caffeoyl]-beta-D-glucosyl)-(1->2)-beta-D-glucoside] => (E)-caffeoyl-CoA + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside"}
{"X":57409,"RHEA_ID":59883,"compounds":"4-hydroxyphenylacetate + FMNH2 + O2 <=> 3,4-dihydroxyphenylacetate + FMN + H(+) + H2O"}
{"X":57410,"RHEA_ID":57218,"compounds":"N(2)-(1-hydroxy-2-oxoethyl)-dGTP => dGTP + glyoxal"}
{"X":57411,"RHEA_ID":58333,"compounds":"(E)-non-2-en-1-ol + NADP(+) => (E)-non-2-enal + H(+) + NADPH"}
{"X":57412,"RHEA_ID":59488,"compounds":"ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol = ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol"}
{"X":57413,"RHEA_ID":59489,"DIRECTION":"LR","MASTER_ID":59488,"metacyc":"RXN-11339","compounds":"ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol => ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol"}
{"X":57414,"RHEA_ID":58705,"compounds":"rifampicin hemiaminal => rifampicin ortho-naphthoquinone carboxamide"}
{"X":57415,"RHEA_ID":59622,"compounds":"4-aminobutanoate + L-lysine => H2O + N(2)-(4-aminobutanoyl)-L-lysine"}
{"X":57416,"RHEA_ID":59887,"compounds":"2-oxoglutarate + chloride + H(+) + L-lysine + O2 <=> 4-chloro-L-lysine + CO2 + H2O + succinate"}
{"X":57417,"RHEA_ID":60894,"compounds":"a 5'-end phospho-ribonucleoside in snoRNA + H(+) + NAD(+) => a 5'-end NAD(+)-phospho-ribonucleoside in snoRNA + H2O"}
{"X":57418,"RHEA_ID":59892,"compounds":"L-2-amino-4-chloropent-4-enoate = chloride + H(+) + L-propargylglycine"}
{"X":57419,"RHEA_ID":57227,"compounds":"glyoxal + GTP <=> N(2)-(1-hydroxy-2-oxoethyl)-GTP"}
{"X":57420,"RHEA_ID":56502,"compounds":"CO2 + isopentenyl phosphate + phosphate => (R)-3,5-bisphosphomevalonate + H(+)"}
{"X":57421,"RHEA_ID":58342,"compounds":"chenodeoxycholate + D-glucose => beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O"}
{"X":57422,"RHEA_ID":59629,"compounds":"H2O + N(2)-(4-aminobutanoyl)-L-arginine => 4-aminobutanoate + L-arginine"}
{"X":57423,"RHEA_ID":62671,"compounds":"deoxyherqueinone + H(+) + NADPH + O2 <=> H2O + herqueinone + NADP(+)"}
{"X":57424,"RHEA_ID":62045,"compounds":"a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphoglycerol + H2O => (9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphoglycerol + H(+)"}
{"X":57425,"RHEA_ID":60036,"DIRECTION":"UN","MASTER_ID":60036,"ec":"3.5.1.133","compounds":"H2O + N(2)-(3-hydroxy-3-methylhexanoyl)-L-glutaminate = 3-hydroxy-3-methylhexanoate + L-glutamine"}
{"X":57426,"RHEA_ID":62521,"compounds":"a cytidine in rRNA + S-adenosyl-L-methionine => an N(4)-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":57427,"RHEA_ID":62522,"compounds":"an N(4)-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in rRNA + S-adenosyl-L-methionine"}
{"X":57428,"RHEA_ID":58719,"compounds":"FADH2-C4alpha-hydroperoxide + NADH + rifampicin <=> FADH2 + H(+) + H2O + NAD(+) + rifampicin hemiaminal"}
{"X":57429,"RHEA_ID":61603,"compounds":"[DsbD protein]-disulfide + [protein]-dithiol <=> [DsbB protein]-dithiol + [protein]-disulfide"}
{"X":57430,"RHEA_ID":58595,"compounds":"1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH <=> 1-hexadecanoyl-2-(9-hydroxynonanoyl)-sn-glycero-3-phosphocholine + NADP(+)"}
{"X":57431,"RHEA_ID":62525,"compounds":"cytidine(839) in 12S rRNA + S-adenosyl-L-methionine => H(+) + N(4)-methylcytidine(839) in 12S rRNA + S-adenosyl-L-homocysteine"}
{"X":57432,"RHEA_ID":57987,"compounds":"(20S)-ginsenoside Rg3 + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rd + H(+) + UDP"}
{"X":57433,"RHEA_ID":61606,"compounds":"[DsbA protein]-disulfide + [DsbB protein]-dithiol => [DsbA protein]-dithiol + [DsbB protein]-disulfide"}
{"X":57434,"RHEA_ID":57618,"compounds":"dihydro-ML-236C carboxylate + H(+) + holo-[compactin nonaketide synthase] => dihydro-ML-236C-[compactin nonaketide synthase] + H2O"}
{"X":57435,"RHEA_ID":62057,"compounds":"alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+)"}
{"X":57436,"RHEA_ID":59907,"compounds":"H2O + NADP(+) + octanal <=> 2 H(+) + NADPH + octanoate"}
{"X":57437,"RHEA_ID":61207,"compounds":"L-arginyl-[protein] + L-cysteinyl-[protein] + methylglyoxal <=> H(+) + 2 H2O + N(5)-[4-(S-L-cysteinyl-[protein])-5-methyl-1H-imidazol-2-yl]-L-ornithinyl-[protein]"}
{"X":57438,"RHEA_ID":62061,"compounds":"alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+)"}
{"X":57439,"RHEA_ID":59783,"compounds":"L-histidine + S-adenosyl-L-methionine <=> (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine"}
{"X":57440,"RHEA_ID":56522,"compounds":"2 5'-deoxyadenosine + 2 CO2 + heme b + 2 L-methionine => Fe-coproporphyrin III + 2 S-adenosyl-L-methionine"}
{"X":57441,"RHEA_ID":56523,"compounds":"Fe-coproporphyrin III + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + 2 CO2 + heme b + 2 L-methionine"}
{"X":57442,"RHEA_ID":62536,"compounds":"2 [Fe(II)cytochrome c] + digoxigenin + 3 H(+) = 2 [Fe(III)cytochrome c] + dihydrodigoxigenin"}
{"X":57443,"RHEA_ID":62066,"compounds":"2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADH => 2-deoxy-D-glucose 6-phosphate + NAD(+)"}
{"X":57444,"RHEA_ID":60778,"compounds":"CO2 + gibberellin A15 + succinate => 2-oxoglutarate + gibberellin A12 + O2"}
{"X":57445,"RHEA_ID":56527,"compounds":"A + dihydro-heme d1 <=> AH2 + heme d1"}
{"X":57446,"RHEA_ID":57630,"compounds":"H2O + ML-236C carboxylate => 3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate"}
{"X":57447,"RHEA_ID":58370,"compounds":"(2E,6Z)-nona-2,6-dienal + H(+) + NADPH => (2E,6Z)-nona-2,6-dien-1-ol + NADP(+)"}
{"X":57448,"RHEA_ID":59919,"compounds":"(2E)-octenal + H2O + NADP(+) <=> (2E)-octenoate + 2 H(+) + NADPH"}
{"X":57449,"RHEA_ID":59923,"compounds":"(2E)-octenal + H2O + NAD(+) <=> (2E)-octenoate + 2 H(+) + NADH"}
{"X":57450,"RHEA_ID":57634,"compounds":"H(+) + H2O + ML-236A carboxylate + oxidized [NADPH--hemoprotein reductase] => ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":57451,"RHEA_ID":59525,"compounds":"9S,10-epoxy-(10,12Z)-octadecadienoate + H(+) + L-aspartyl-[protein] => 9-O-10-oxo-(12Z)-octadecenoate L-aspartatyl ester-[protein]"}
{"X":57452,"RHEA_ID":60785,"DIRECTION":"LR","MASTER_ID":60784,"metacyc":"RXN1F-99","compounds":"2-oxoglutarate + gibberellin A24 + O2 => CO2 + gibberellin A25 + H(+) + succinate"}
{"X":57453,"RHEA_ID":62074,"compounds":"6-phospho-D-galactono-1,5-lactone + H(+) + NADPH => D-galactose 6-phosphate + NADP(+)"}
{"X":57454,"RHEA_ID":62077,"compounds":"D-galactose 6-phosphate + NAD(+) => 6-phospho-D-galactono-1,5-lactone + H(+) + NADH"}
{"X":57455,"RHEA_ID":59531,"compounds":"hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein] <=> CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]"}
{"X":57456,"RHEA_ID":58131,"compounds":"A + O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine <=> AH2 + alstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":57457,"RHEA_ID":59124,"DIRECTION":"UN","MASTER_ID":59124,"ec":"6.3.2.54","compounds":"(S)-2,3-diaminopropanoate + ATP + citrate = 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + AMP + diphosphate"}
{"X":57458,"RHEA_ID":62081,"compounds":"D-glucose 6-sulfate + NADP(+) => 6-sulfo-D-glucono-1,5-lactone + H(+) + NADPH"}
{"X":57459,"RHEA_ID":57267,"compounds":"H2O + N(2)-(1-hydroxy-2-oxoethyl)-GDP <=> GDP + glycolate + H(+)"}
{"X":57460,"RHEA_ID":58383,"compounds":"NADP(+) + nonan-1-ol <=> H(+) + NADPH + nonanal"}
{"X":57461,"RHEA_ID":56543,"compounds":"(9Z)-octadecenoyl-CoA + 1,2-dihexanoyl-sn-glycerol <=> 1,2-dihexanoyl-3-(9Z-octadecenoyl)-sn-glycerol + CoA"}
{"X":57462,"RHEA_ID":62085,"DIRECTION":"LR","MASTER_ID":62084,"metacyc":"RXN-12545","compounds":"ADP + D-glucosamine => AMP + D-glucosamine 6-phosphate + H(+)"}
{"X":57463,"RHEA_ID":61233,"compounds":"H2O + L-isoleucine + O2 => (S)-3-methyl-2-oxopentanoate + H2O2 + NH4(+)"}
{"X":57464,"RHEA_ID":59540,"DIRECTION":"UN","MASTER_ID":59540,"ec":"4.1.1.94","compounds":"(2R)-ethylmalonyl-CoA + H(+) = butanoyl-CoA + CO2"}
{"X":57465,"RHEA_ID":59951,"compounds":"H2O + prostaglandin F2alpha-CoA <=> CoA + H(+) + prostaglandin F2alpha"}
{"X":57466,"RHEA_ID":59952,"compounds":"2,6-dimethylheptanoyl-CoA + H2O = 2,6-dimethylheptanoate + CoA + H(+)"}
{"X":57467,"RHEA_ID":59543,"compounds":"(2R)-ethylmalonyl-CoA + H(+) <=> butanoyl-CoA + CO2"}
{"X":57468,"RHEA_ID":58391,"compounds":"4-aminobenzoate + all-trans-hexaprenyl diphosphate <=> 4-amino-3-all-trans-hexaprenylbenzoate + diphosphate"}
{"X":57469,"RHEA_ID":60826,"compounds":"2 AMP + 2 H(+) => H2O + P(1),P(2)-bis(5'-adenosyl) diphosphate"}
{"X":57470,"RHEA_ID":59955,"compounds":"2,6-dimethylheptanoyl-CoA + H2O <=> 2,6-dimethylheptanoate + CoA + H(+)"}
{"X":57471,"RHEA_ID":59547,"compounds":"N,N'-diacetylchitobiose + O2 <=> H2O2 + N,N'-diacetylchitobiono-1,5-lactone"}
{"X":57472,"RHEA_ID":59962,"compounds":"N(alpha)-acetyl-L-methionine => N(alpha)-acetyl-D-methionine"}
{"X":57473,"RHEA_ID":56555,"compounds":"[rhodopsin]-L-threonine + ATP <=> [rhodopsin]-O-phospho-L-threonine + ADP + H(+)"}
{"X":57474,"RHEA_ID":62097,"compounds":"2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 2-(9Z-octadecenoyl)-glycerol + phosphate"}
{"X":57475,"RHEA_ID":59963,"compounds":"N(alpha)-acetyl-D-methionine <=> N(alpha)-acetyl-L-methionine"}
{"X":57476,"RHEA_ID":61666,"compounds":"(2E,6E,10E)-geranylgeranyl phosphate + ADP + H(+) => (2E,6E,10E)-geranylgeraniol + ATP"}
{"X":57477,"RHEA_ID":56559,"compounds":"(2E,6E)-farnesyl diphosphate <=> delta-cadinene + diphosphate"}
{"X":57478,"RHEA_ID":62101,"compounds":"1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate"}
{"X":57479,"RHEA_ID":62582,"compounds":"ADP + D-cystine(in) + H(+) + phosphate => ATP + D-cystine(out) + H2O"}
{"X":57480,"RHEA_ID":58403,"compounds":"heptan-1-ol + NADP(+) <=> H(+) + heptanal + NADPH"}
{"X":57481,"RHEA_ID":56563,"compounds":"[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose <=> [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + H(+) + UDP"}
{"X":57482,"RHEA_ID":62105,"compounds":"(9Z)-octadecenoyl-CoA + sn-glycero-3-phosphoethanolamine => (9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA"}
{"X":57483,"RHEA_ID":62106,"compounds":"(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + sn-glycero-3-phosphoethanolamine"}
{"X":57484,"RHEA_ID":59691,"compounds":"D-maltoheptaose + O2 <=> D-maltoheptaono-1,5-lactone + H2O2"}
{"X":57485,"RHEA_ID":60510,"compounds":"an N(7)-methylguanosine in mRNA + S-adenosyl-L-homocysteine => a guanosine in mRNA + S-adenosyl-L-methionine"}
{"X":57486,"RHEA_ID":60967,"compounds":"(9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + UDP-alpha-D-glucose <=> (9Z)-17-hydroxyoctadec-9-enoate 17-O-sophoroside + H(+) + UDP"}
{"X":57487,"RHEA_ID":62237,"DIRECTION":"LR","MASTER_ID":62236,"metacyc":"RXN-19241","compounds":"a cytidine(6-4)cytidine in DNA => a cytidine dimer in DNA + H(+)"}
{"X":57488,"RHEA_ID":59832,"DIRECTION":"UN","MASTER_ID":59832,"ec":"2.7.1.171","compounds":"ATP + N(6)-(D-fructosyl)-L-lysyl-[protein] = ADP + H(+) + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein]"}
{"X":57489,"RHEA_ID":61378,"compounds":"5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(out) + ADP + H(+) + phosphate => 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(in) + ATP + H2O"}
{"X":57490,"RHEA_ID":62242,"compounds":"a thymine-cytidine dinucleotide in DNA => a thymidine(6-4)cytidine in DNA"}
{"X":57491,"RHEA_ID":60849,"compounds":"a 5'-end diphospho-guanosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] => a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + L-lysyl-[protein]"}
{"X":57492,"RHEA_ID":60850,"compounds":"a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + L-lysyl-[protein] => a 5'-end diphospho-guanosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein]"}
{"X":57493,"RHEA_ID":58415,"compounds":"3 H(+) + hydrogen sulfide + L-aspartate 4-semialdehyde + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + L-homocysteine + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":57494,"RHEA_ID":58784,"compounds":"2-oxoglutarate + a 5'-methyltriphosphate-guanosine-ribonucleotide-snRNA + O2 = a 5'-triphospho-guanosine-ribonucleotide-snRNA + CO2 + formaldehyde + H(+) + succinate"}
{"X":57495,"RHEA_ID":57303,"compounds":"an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA + H2O <=> a 2'-deoxyguanosine in DNA + H(+) + lactate"}
{"X":57496,"RHEA_ID":57304,"compounds":"H2O + N(2)-(1-hydroxy-2-oxoethyl)-GMP = glycolate + GMP + H(+)"}
{"X":57497,"RHEA_ID":59572,"DIRECTION":"UN","MASTER_ID":59572,"ec":"3.4.13.20","compounds":"H2O + L-homocarnosine = 4-aminobutanoate + L-histidine"}
{"X":57498,"RHEA_ID":62601,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 => 5-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate"}
{"X":57499,"RHEA_ID":60857,"compounds":"a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-homocysteine"}
{"X":57500,"RHEA_ID":57308,"DIRECTION":"UN","MASTER_ID":57308,"ec":"2.7.7.103","compounds":"CTP + H(+) + N(5)-phospho-L-glutamine = diphosphate + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine"}
{"X":57501,"RHEA_ID":56221,"DIRECTION":"LR","MASTER_ID":56220,"metacyc":"2.4.1.146-RXN","compounds":"3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-seryl-[protein] + H(+) + UDP"}
{"X":57502,"RHEA_ID":59576,"DIRECTION":"UN","MASTER_ID":59576,"ec":"3.4.13.20","compounds":"anserine + H2O = beta-alanine + N(pros)-methyl-L-histidine"}
{"X":57503,"RHEA_ID":59576,"DIRECTION":"UN","MASTER_ID":59576,"ec":"3.4.13.5","compounds":"anserine + H2O = beta-alanine + N(pros)-methyl-L-histidine"}
{"X":57504,"RHEA_ID":61394,"compounds":"ADP + H(+) + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein] => ATP + N(6)-(D-psicosyl)-L-lysyl-[protein]"}
{"X":57505,"RHEA_ID":58674,"compounds":"aldehydo-D-glucuronate => D-glucuronate"}
{"X":57506,"RHEA_ID":59855,"compounds":"(2S,3R)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH <=> (R)-tetrahydrodehydrodiconiferyl alcohol + NADP(+)"}
{"X":57507,"RHEA_ID":62132,"compounds":"a 2'-deoxyribonucleoside 5'-phosphate + dTTP = a 2'-deoxyribonucleoside 5'-diphosphate + dTDP"}
{"X":57508,"RHEA_ID":60866,"compounds":"a 5'-end (N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-guanosine) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine"}
{"X":57509,"RHEA_ID":56590,"compounds":"an aldehyde + hydrogen cyanide => a monosubstituted aliphatic (S)-hydroxynitrile"}
{"X":57510,"RHEA_ID":58805,"compounds":"5'-pApG-3' + H2O => 5'-ApG-3' + phosphate"}
{"X":57511,"RHEA_ID":60869,"compounds":"a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O => a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(7)-methylguanosine 5'-diphosphate"}
{"X":57512,"RHEA_ID":62264,"compounds":"hydrogencarbonate(out) + selenite(out) + Zn(2+)(out) = hydrogencarbonate(in) + selenite(in) + Zn(2+)(in)"}
{"X":57513,"RHEA_ID":56594,"compounds":"a ketone + hydrogen cyanide => a disubstituted aliphatic (S)-hydroxynitrile"}
{"X":57514,"RHEA_ID":58067,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + xanthotoxin <=> 5-hydroxyxanthotoxin + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":57515,"RHEA_ID":62618,"compounds":"a lactoside IV(2),III(4)-a-[Fuc]2-Lc4Cer + GDP + H(+) => a lactoside III(4)-a-Fuc-Lc4Cer + GDP-beta-L-fucose"}
{"X":57516,"RHEA_ID":59590,"compounds":"ADP + beta-alanyl-L-ornithine + H(+) + phosphate => ATP + beta-alanine + L-ornithine"}
{"X":57517,"RHEA_ID":62266,"compounds":"hydrogencarbonate(in) + selenite(in) + Zn(2+)(in) => hydrogencarbonate(out) + selenite(out) + Zn(2+)(out)"}
{"X":57518,"RHEA_ID":57450,"compounds":"AMP + D-tyrosyl-tRNA(Tyr) + diphosphate + H(+) => ATP + D-tyrosine + tRNA(Tyr)"}
{"X":57519,"RHEA_ID":61287,"compounds":"H2O + L-cystine + O2 <=> (2R)-2-amino-2-carboxylatoethyl-disulfanyl-oxopropanoate + H2O2 + NH4(+)"}
{"X":57520,"RHEA_ID":62619,"compounds":"a lactoside III(4)-a-Fuc-Lc4Cer + GDP-beta-L-fucose <=> a lactoside IV(2),III(4)-a-[Fuc]2-Lc4Cer + GDP + H(+)"}
{"X":57521,"RHEA_ID":57713,"DIRECTION":"LR","MASTER_ID":57712,"metacyc":"RXN-92","compounds":"(E)-sinapoaldehyde + UDP-alpha-D-glucose => 4-O-(beta-D-glucosyl)-4-trans-sinapoyl aldehyde + H(+) + UDP"}
{"X":57522,"RHEA_ID":62021,"compounds":"H2O + sitosteryl 3-beta-D-glucoside => (24R)-ethylcholest-5-en-3beta-ol + D-glucose"}
{"X":57523,"RHEA_ID":59729,"compounds":"(2R)-ethylmalonyl-CoA => (2S)-ethylmalonyl-CoA"}
{"X":57524,"RHEA_ID":60882,"compounds":"a 5'-end phospho-ribonucleoside in mRNA + H(+) + NAD(+) => a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O"}
{"X":57525,"RHEA_ID":58447,"compounds":"N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N-methyl-L-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine"}
{"X":57526,"RHEA_ID":57334,"compounds":"3 3-oxopropanoate + 3 H(+) + H2O2 + 2 nitrate + nitrite => H2O + 3 O2 + 3 propionate 3-nitronate"}
{"X":57527,"RHEA_ID":62154,"compounds":"dGDP + dTDP => dGMP + dTTP"}
{"X":57528,"RHEA_ID":59614,"compounds":"beta-alanine + L-ornithine => beta-alanyl-L-ornithine + H2O"}
{"X":57529,"RHEA_ID":56610,"compounds":"L-serine + tetrahydrosulfopterin => 5,10-methylenetetrahydrosulfopterin + glycine + H2O"}
{"X":57530,"RHEA_ID":59615,"compounds":"beta-alanyl-L-ornithine + H2O <=> beta-alanine + L-ornithine"}
{"X":57531,"RHEA_ID":59616,"DIRECTION":"UN","MASTER_ID":59616,"ec":"3.4.13.4","compounds":"beta-alanyl-L-arginine + H2O = beta-alanine + L-arginine"}
{"X":57532,"RHEA_ID":56613,"compounds":"L-cysteinyl-[protein] + NAD(+) => H(+) + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]"}
{"X":57533,"RHEA_ID":56251,"compounds":"1,2-didodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] <=> 2-dodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl dodecanoate + apo--[retinol-binding protein]"}
{"X":57534,"RHEA_ID":56252,"compounds":"3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-seryl-[protein] + UDP"}
{"X":57535,"RHEA_ID":62166,"compounds":"D-glucosamine + N-acetyl-D-glucosamine => beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine + H2O"}
{"X":57536,"RHEA_ID":58211,"compounds":"A + dihydroalstonine <=> AH2 + alstonine"}
{"X":57537,"RHEA_ID":62663,"compounds":"2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol <=> (2'R)-atrovenetin"}
{"X":57538,"RHEA_ID":59620,"DIRECTION":"UN","MASTER_ID":59620,"ec":"3.4.13.4","compounds":"H2O + N(2)-(4-aminobutanoyl)-L-lysine = 4-aminobutanoate + L-lysine"}
{"X":57539,"RHEA_ID":60616,"compounds":"N-dodecanoyl-heptadecasphing-4-enine-1-phosphoethanolamine = ethanolamine + N-dodecanoyl-heptadecasphing-4-enine-1,3-cyclic phosphate"}
{"X":57540,"RHEA_ID":59747,"compounds":"(9Z)-octadecenoyl-CoA + L-cysteinyl-[protein] <=> CoA + S-(9Z-octadecenoyl)-L-cysteinyl-[protein]"}
{"X":57541,"RHEA_ID":61188,"compounds":"quercetin 3-O-beta-D-glucoside + UDP-beta-L-rhamnose = H(+) + quercetin 3-O-beta-D-glucoside-7-O-alpha-L-rhamnoside + UDP"}
{"X":57542,"RHEA_ID":57602,"compounds":"2 [Fe(III)-cytochrome b5] + a 1-[(17Z)-hexacos-17-enoyl]-2-acyl-phosphoglycerolipid + 2 H2O => 2 [Fe(II)-cytochrome b5] + a 1-hexacosanoyl-2-acyl-phosphoglycerolipid + 2 H(+) + O2"}
{"X":57543,"RHEA_ID":60745,"DIRECTION":"LR","MASTER_ID":60744,"metacyc":"RXN-12678","compounds":"(1R,3R)-chrysanthemoyl-CoA + (Z,S)-pyrethrolone => CoA + pyrethrin I"}
{"X":57544,"RHEA_ID":58465,"compounds":"a neolactoside nLc4Cer + UDP-N-acetyl-alpha-D-glucosamine => a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + H(+) + UDP"}
{"X":57545,"RHEA_ID":62176,"compounds":"GDP-alpha-D-glucose + H2O = alpha-D-glucose 1-phosphate + GMP + 2 H(+)"}
{"X":57546,"RHEA_ID":57478,"compounds":"2-hydroxydodecanoate + H2O => dodecanoate + H2O2"}
{"X":57547,"RHEA_ID":56265,"DIRECTION":"LR","MASTER_ID":56264,"metacyc":"RXN-19002","compounds":"CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => CMP + H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]"}
{"X":57548,"RHEA_ID":56629,"DIRECTION":"LR","MASTER_ID":56628,"metacyc":"RXN-10077","compounds":"5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H2O => chloride + 2 H(+) + maleylacetate"}
{"X":57549,"RHEA_ID":56267,"compounds":"CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] <=> CMP + H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]"}
{"X":57550,"RHEA_ID":60911,"compounds":"a cytidine in tRNA + S-adenosyl-L-methionine <=> an N(3)-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":57551,"RHEA_ID":57983,"compounds":"(20S)-protopanaxatriol + UDP-alpha-D-glucose <=> (20S)-ginsenoside F1 + H(+) + UDP"}
{"X":57552,"RHEA_ID":58976,"compounds":"H2O + malonaldehyde + O2 = 3-oxopropanoate + H(+) + H2O2"}
{"X":57553,"RHEA_ID":56634,"compounds":"1,8-cineole + diphosphate => H2O + neryl diphosphate"}
{"X":57554,"RHEA_ID":57745,"compounds":"[protein]-disulfide + phylloquinol => [protein]-dithiol + phylloquinone"}
{"X":57555,"RHEA_ID":62185,"compounds":"peregrinol diphosphate => diphosphate + labd-13(16),14-diene-9-ol"}
{"X":57556,"RHEA_ID":59642,"compounds":"D-xylotetraono-1,5-lactone + H2O2 => D-xylotetraose + O2"}
{"X":57557,"RHEA_ID":61327,"compounds":"(+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta-hydroxycostunolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":57558,"RHEA_ID":61812,"compounds":"3beta-hydroxyandrost-5-en-17-one + UDP-alpha-D-glucose = dehydroepiandrosterone 3-beta-D-glucoside + H(+) + UDP"}
{"X":57559,"RHEA_ID":61085,"DIRECTION":"LR","MASTER_ID":61084,"metacyc":"NARINGENIN-3-DIOXYGENASE-RXN","compounds":"(S)-naringenin + 2-oxoglutarate + O2 => (2R,3R)-dihydrokaempferol + CO2 + succinate"}
{"X":57560,"RHEA_ID":58729,"compounds":"adenosine in rRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine in rRNA + S-adenosyl-L-homocysteine"}
{"X":57561,"RHEA_ID":62059,"compounds":"alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose <=> alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+)"}
{"X":57562,"RHEA_ID":60052,"compounds":"a 3beta-hydroxy-4,4-dimethylsteroid + H(+) + NADH + O2 = a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H2O + NAD(+)"}
{"X":57563,"RHEA_ID":60053,"DIRECTION":"LR","MASTER_ID":60052,"metacyc":"RXN-20106","compounds":"a 3beta-hydroxy-4,4-dimethylsteroid + H(+) + NADH + O2 => a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H2O + NAD(+)"}
{"X":57564,"RHEA_ID":58486,"compounds":"acetate + sphing-4-enine => H2O + N-(acetyl)-sphing-4-enine"}
{"X":57565,"RHEA_ID":58488,"compounds":"4-(trimethylamino)butanoate + H(+) + NADH + O2 = H2O + NAD(+) + succinate semialdehyde + trimethylamine"}
{"X":57566,"RHEA_ID":61092,"compounds":"H2O + N(2)-acetyl-L-citrulline = acetate + L-citrulline"}
{"X":57567,"RHEA_ID":62321,"compounds":"(+)-premalbrancheamide + chloride + FAD + 2 H(+) => (+)-isomalbrancheamide B + FADH2"}
{"X":57568,"RHEA_ID":62706,"compounds":"2,3-didehydrophenylalanine + glycine => glycyldehydrophenylalanine + H2O"}
{"X":57569,"RHEA_ID":62198,"compounds":"2 [Fe(II)cytochrome c] + acetone + 2 H(+) => 2 [Fe(III)cytochrome c] + propan-2-ol"}
{"X":57570,"RHEA_ID":58492,"DIRECTION":"UN","MASTER_ID":58492,"ec":"7.2.2.17","compounds":"ATP + Fe(III)-enterobactin(out) + H2O = ADP + Fe(III)-enterobactin(in) + H(+) + phosphate"}
{"X":57571,"RHEA_ID":62202,"compounds":"2 [Fe(II)cytochrome c] + acetaldehyde + 2 H(+) => 2 [Fe(III)cytochrome c] + ethanol"}
{"X":57572,"RHEA_ID":60934,"compounds":"17-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":57573,"RHEA_ID":56654,"DIRECTION":"RL","MASTER_ID":56652,"metacyc":"BADEL4OXRED-RXN","compounds":"12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH => 12alpha-hydroxy-3-oxocholan-24-oyl-CoA + NAD(+)"}
{"X":57574,"RHEA_ID":59662,"compounds":"D-cellotetraono-1,5-lactone + H2O2 => D-cellotetraose + O2"}
{"X":57575,"RHEA_ID":57518,"compounds":"15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dolabradiene + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":57576,"RHEA_ID":59801,"compounds":"decanoyl-CoA + L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein] => CoA + H(+) + N(6)-decanoyl-L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein]"}
{"X":57577,"RHEA_ID":56660,"DIRECTION":"UN","MASTER_ID":56660,"ec":"1.3.1.115","compounds":"7alpha-hydroxy-3-oxochol-24-oyl-CoA + NAD(+) = 7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH"}
{"X":57578,"RHEA_ID":62718,"compounds":"stemphyloxin II => stemphyloxin I"}
{"X":57579,"RHEA_ID":61351,"compounds":"ATP + estrone 3-sulfate(in) + H2O <=> ADP + estrone 3-sulfate(out) + H(+) + phosphate"}
{"X":57580,"RHEA_ID":58876,"compounds":"4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O"}
{"X":57581,"RHEA_ID":59805,"compounds":"L-phenylalanine => D-phenylalanine"}
{"X":57582,"RHEA_ID":57776,"DIRECTION":"UN","MASTER_ID":57776,"ec":"1.14.12.23","metacyc":"RXN-16803","compounds":"2-chloro-6-nitrotoluene + NADH + O2 = 4-chloro-3-methylcatechol + NAD(+) + nitrite"}
{"X":57583,"RHEA_ID":56666,"compounds":"7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH => 7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + NAD(+)"}
{"X":57584,"RHEA_ID":59672,"compounds":"D-maltotriose + O2 = D-maltotriono-1,5-lactone + H2O2"}
{"X":57585,"RHEA_ID":57031,"compounds":"FADH2 + N-methylnicotinate + O2 <=> (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FAD + H(+)"}
{"X":57586,"RHEA_ID":60477,"compounds":"2 ATP + GTP => cyclic AMP-AMP-GMP + 3 diphosphate"}
{"X":57587,"RHEA_ID":61843,"compounds":"brassicasterol + UDP-alpha-D-glucose <=> brassicasterol 3-beta-D-glucoside + H(+) + UDP"}
{"X":57588,"RHEA_ID":60079,"compounds":"4beta-hydroxymethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADH + O2 <=> 4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H2O + NAD(+)"}
{"X":57589,"RHEA_ID":62222,"compounds":"neopatulin => phyllostine"}
{"X":57590,"RHEA_ID":58886,"compounds":"A + chloramphenicol + 2 H2O => AH2 + alpha-N-dichloroacetyl-p-aminophenylserinol + 2 O2"}
{"X":57591,"RHEA_ID":61362,"compounds":"ADP + H(+) + pheophorbide a(out) + phosphate => ATP + H2O + pheophorbide a(in)"}
{"X":57592,"RHEA_ID":60083,"compounds":"4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADH + O2 <=> 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + H2O + NAD(+)"}
{"X":57593,"RHEA_ID":61365,"compounds":"3beta-sulfooxy-androst-5-en-17-one(in) + ATP + H2O => 3beta-sulfooxy-androst-5-en-17-one(out) + ADP + H(+) + phosphate"}
{"X":57594,"RHEA_ID":60084,"DIRECTION":"UN","MASTER_ID":60084,"ec":"1.1.1.417","compounds":"a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NAD(+) = a 4alpha-methyl-3-oxosteroid + CO2 + NADH"}
{"X":57595,"RHEA_ID":56315,"compounds":"3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O <=> 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + 2 H(+) + phosphate"}
{"X":57596,"RHEA_ID":59296,"compounds":"an N-acylglycine + 2 L-ascorbate + O2 = an N-acyl-(2S)-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical"}
{"X":57597,"RHEA_ID":59683,"compounds":"D-maltopentaose + O2 <=> D-maltopentaono-1,5-lactone + H2O2"}
{"X":57598,"RHEA_ID":62738,"compounds":"1-hydroxy-3-{[2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl]methyl}-6H,7H,8H-5lambda5-pyrrolo[1,2-a]pyrazine + diphosphate => 1-hydroxy-3-(1H-indol-3-ylmethyl)-6H,7H,8H-5lambda5-pyrrolo[1,2-a]pyrazin-5-ylium + dimethylallyl diphosphate"}
{"X":57599,"RHEA_ID":60506,"compounds":"a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+) => 1D-myo-inositol 3-phosphate + a CDP-1,2-diacyl-sn-glycerol"}
{"X":57600,"RHEA_ID":57414,"DIRECTION":"RL","MASTER_ID":57412,"metacyc":"RXN-19914","compounds":"ATP + H(+) + L-tyrosine + NADPH => AMP + diphosphate + L-tyrosinal + NADP(+)"}
{"X":57601,"RHEA_ID":58906,"compounds":"C40-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+) => 8 (S)-methylmalonyl-CoA + 24 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 16 NADPH"}
{"X":57602,"RHEA_ID":60966,"compounds":"(9Z)-17-hydroxyoctadec-9-enoate 17-O-sophoroside + H(+) + UDP => (9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + UDP-alpha-D-glucose"}
{"X":57603,"RHEA_ID":59971,"compounds":"L-threonyl-[protein] + octanoyl-CoA <=> CoA + O-octanoyl-L-threonyl-[protein]"}
{"X":57604,"RHEA_ID":58285,"compounds":"5,6-dihydrothymine + NADP(+) => H(+) + NADPH + thymine"}
{"X":57605,"RHEA_ID":58653,"compounds":"rifamycin SV ortho-naphthoquinone carboxamide => rifamycin SV para-naphthoquinone carboxamide"}
{"X":57606,"RHEA_ID":62361,"DIRECTION":"LR","MASTER_ID":62360,"ecocyc":"RXN-20707","metacyc":"RXN-20707","compounds":"FMNH2 + O2 + uracil => (Z)-3-ureidoacrylate + FMN-N(5)-oxide + 2 H(+)"}
{"X":57607,"RHEA_ID":57093,"compounds":"AH2 + S-(methylsulfanyl)glutathione => A + glutathione + methanethiol"}
{"X":57608,"RHEA_ID":57462,"compounds":"4-O-(beta-D-glucosyl)-trans-4-sinapoyl alcohol + H(+) + UDP => (E)-sinapoyl alcohol + UDP-alpha-D-glucose"}
{"X":57609,"RHEA_ID":59350,"compounds":"D-maltobionate + H(+) => D-maltobiono-1,5-lactone + H2O"}
{"X":57610,"RHEA_ID":59564,"compounds":"H2O + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone = H(+) + N,N',N'',N'''-tetraacetylchitotetraonate"}
{"X":57611,"RHEA_ID":58413,"DIRECTION":"LR","MASTER_ID":58412,"metacyc":"RXN-19380","compounds":"3 H(+) + hydrogen sulfide + L-aspartate 4-semialdehyde + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + L-homocysteine + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":57612,"RHEA_ID":59700,"compounds":"D-cellopentaono-1,5-lactone + H2O = D-cellopentaonate + H(+)"}
{"X":57613,"RHEA_ID":60104,"DIRECTION":"UN","MASTER_ID":60104,"ec":"1.3.8.15","compounds":"3-(1H-indol-3-yl)propanoate + H(+) + oxidized [electron-transfer flavoprotein] = (E)-3-(indol-3-yl)acrylate + reduced [electron-transfer flavoprotein]"}
{"X":57614,"RHEA_ID":59701,"compounds":"D-cellopentaono-1,5-lactone + H2O => D-cellopentaonate + H(+)"}
{"X":57615,"RHEA_ID":60522,"compounds":"2 glycine + L-cystine => 2 H2O + L-cystine-bis-glycine"}
{"X":57616,"RHEA_ID":58666,"compounds":"2-oxoglutarate + a quinol => (S)-2-hydroxyglutarate + a quinone"}
{"X":57617,"RHEA_ID":62249,"compounds":"chloroacetaldehyde + H2O + NADP(+) => chloroacetate + 2 H(+) + NADPH"}
{"X":57618,"RHEA_ID":61997,"compounds":"L-lysyl-[protein] + lactoyl-CoA => CoA + H(+) + N(6)-lactoyl-L-lysyl-[protein]"}
{"X":57619,"RHEA_ID":59707,"compounds":"D-cellohexaono-1,5-lactone + H2O <=> D-cellohexaonate + H(+)"}
{"X":57620,"RHEA_ID":57434,"compounds":"1,2,3-trihydroxybenzene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] => 3-methoxycatechol + O2 + reduced [NADH--hemoprotein reductase]"}
{"X":57621,"RHEA_ID":62254,"compounds":"2 hydrogencarbonate(in) + Zn(2+)(in) => 2 hydrogencarbonate(out) + Zn(2+)(out)"}
{"X":57622,"RHEA_ID":60989,"compounds":"(E)-hex-2-en-1-ol + NAD(+) => (E)-2-hexenal + H(+) + NADH"}
{"X":57623,"RHEA_ID":62406,"compounds":"CO2 + H2O + pentadecanoate => (R)-2-hydroxyhexadecanoate + O2"}
{"X":57624,"RHEA_ID":62607,"compounds":"(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> 7-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate"}
{"X":57625,"RHEA_ID":56586,"compounds":"propane-1,2-diol => 1,2-epoxypropane + H2O"}
{"X":57626,"RHEA_ID":62421,"DIRECTION":"LR","MASTER_ID":62420,"metacyc":"RXN-21180","compounds":"a (R)-2-hydroxy fatty acid + O2 => a fatty acid + CO2 + H2O"}
{"X":57627,"RHEA_ID":58677,"compounds":"NADPH + O2 + rifamycin SV => H2O + NADP(+) + rifamycin SV para-naphthoquinone carboxamide"}
{"X":57628,"RHEA_ID":59861,"compounds":"3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->6)-N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP"}
{"X":57629,"RHEA_ID":58554,"compounds":"(16R)-deshydroxymethyl-stemmadenine + formate => 15alpha-stemmadenine intermediate II + H2O"}
{"X":57630,"RHEA_ID":62262,"compounds":"2 hydrogencarbonate(in) + Mn(2+)(in) => 2 hydrogencarbonate(out) + Mn(2+)(out)"}
{"X":57631,"RHEA_ID":59583,"compounds":"hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester <=> CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester"}
{"X":57632,"RHEA_ID":56593,"compounds":"a disubstituted aliphatic (S)-hydroxynitrile => a ketone + hydrogen cyanide"}
{"X":57633,"RHEA_ID":62612,"compounds":"adenosine(1832) in 18S rRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(1832) in 18S rRNA + S-adenosyl-L-homocysteine"}
{"X":57634,"RHEA_ID":59722,"compounds":"D-maltohexaonate + H(+) => D-maltohexaono-1,5-lactone + H2O"}
{"X":57635,"RHEA_ID":60568,"compounds":"N-acetyl-L-tryptophan = N-acetyl-D-tryptophan"}
{"X":57636,"RHEA_ID":62465,"compounds":"1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O => 2-nonadioyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":57637,"RHEA_ID":59216,"DIRECTION":"UN","MASTER_ID":59216,"ec":"4.1.1.115","compounds":"(indol-3-yl)acetate + H(+) = CO2 + skatole"}
{"X":57638,"RHEA_ID":57324,"compounds":"acetyl-CoA + N-terminal L-glutamyl-L-glutamyl-L-glutamyl-[protein] = CoA + H(+) + N-terminal N-acetyl-L-glutamyl-L-glutamyl-L-glutamyl-[protein]"}
{"X":57639,"RHEA_ID":61032,"compounds":"3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-methionine = 5-hydroxy-3,7,3',4'-tetramethoxyflavone + H(+) + S-adenosyl-L-homocysteine"}
{"X":57640,"RHEA_ID":58321,"compounds":"25-substituted-cholesterol + a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine => 25-substituted-cholesteryl beta-D-glucoside + an N-acylsphing-4-enine"}
{"X":57641,"RHEA_ID":58443,"compounds":"N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N-terminal N,N,N-trimethyl-L-glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-homocysteine"}
{"X":57642,"RHEA_ID":61453,"compounds":"H(+) + NADPH + O2 + oxytetracycline => 11a-hydroxy-oxytetracycline + H2O + NADP(+)"}
{"X":57643,"RHEA_ID":62274,"compounds":"8 AMP + bassianolide + 8 diphosphate + 8 H(+) + 4 S-adenosyl-L-homocysteine => 4 (R)-2-hydroxy-3-methylbutyrate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine"}
{"X":57644,"RHEA_ID":59473,"compounds":"2',3'-cGAMP + H2O => Gp(2'-5')Ap(3') + H(+)"}
{"X":57645,"RHEA_ID":58570,"compounds":"CoA + O-acetyl-15alpha-stemmadenine => 15alpha-stemmadenine + acetyl-CoA"}
{"X":57646,"RHEA_ID":62025,"compounds":"campesteryl 3-beta-D-glucoside + H2O => campesterol + D-glucose"}
{"X":57647,"RHEA_ID":58615,"compounds":"2 L-ascorbate + N-octanoylglycine + O2 <=> H2O + 2 monodehydro-L-ascorbate radical + N-octanoyl-(2S)-hydroxyglycine"}
{"X":57648,"RHEA_ID":59921,"compounds":"(2E)-octenal + H2O + NAD(+) => (2E)-octenoate + 2 H(+) + NADH"}
{"X":57649,"RHEA_ID":59793,"compounds":"H2O + NADP(+) + yersinopine => (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate"}
{"X":57650,"RHEA_ID":60140,"compounds":"dodecanoyl-CoA + H(+) + malonyl-CoA = 3-oxotetradecanoyl-CoA + CO2 + CoA"}
{"X":57651,"RHEA_ID":62286,"compounds":"(8aS)-3-[(1H-indol-3-yl)methyl]-1H,2H,6H,7H,8H,8aH-pyrrolo[1,2-a]pyrazin-1-one + 2 AMP + 2 diphosphate + H(+) + H2O + NADP(+) => 2 ATP + L-proline + L-tryptophan + NADPH"}
{"X":57652,"RHEA_ID":57466,"compounds":"1-O-[(E)-caffeoyl]-beta-D-glucose + UDP => (E)-caffeate + UDP-alpha-D-glucose"}
{"X":57653,"RHEA_ID":62290,"compounds":"(8aS)-3-{[2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl]methyl}-1H,2H,6H,7H,8H,8aH-pyrrolo[1,2-a]pyrazin-1-one + diphosphate => (8aS)-3-[(1H-indol-3-yl)methyl]-1H,2H,6H,7H,8H,8aH-pyrrolo[1,2-a]pyrazin-1-one + dimethylallyl diphosphate"}
{"X":57654,"RHEA_ID":59742,"compounds":"CoA + S-octadecanoyl-L-cysteinyl-[protein] => L-cysteinyl-[protein] + octadecanoyl-CoA"}
{"X":57655,"RHEA_ID":60278,"compounds":"3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine => L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine"}
{"X":57656,"RHEA_ID":58579,"compounds":"dihydroprecondylocarpine acetate + NADP(+) <=> H(+) + NADPH + precondylocarpine acetate"}
{"X":57657,"RHEA_ID":61303,"compounds":"5-deoxy-D-ribulose 1-phosphate <=> acetaldehyde + dihydroxyacetone phosphate"}
{"X":57658,"RHEA_ID":56418,"compounds":"alpha-D-glucose 1-phosphate + glycerol => 2-O-(alpha-D-glucopyranosyl)glycerol + phosphate"}
{"X":57659,"RHEA_ID":61187,"compounds":"quercitrin + UDP-beta-L-rhamnose <=> H(+) + quercetin 3,7-bis-O-alpha-L-rhamnoside + UDP"}
{"X":57660,"RHEA_ID":61431,"compounds":"cis-trans-nepetalactol + NAD(+) <=> cis-trans-nepetalactone + H(+) + NADH"}
{"X":57661,"RHEA_ID":58629,"compounds":"FADH2-C4alpha-hydroperoxide + H(+) + NADPH + rifamycin SV => FADH2 + H2O + NADP(+) + rifamycin SV hemiaminal"}
{"X":57662,"RHEA_ID":58965,"compounds":"H2O + hexanal + O2 => H(+) + H2O2 + hexanoate"}
{"X":57663,"RHEA_ID":59891,"compounds":"4-chloro-L-lysine + AH2 + O2 <=> A + formaldehyde + H2O + L-2-amino-4-chloropent-4-enoate + NH4(+)"}
{"X":57664,"RHEA_ID":59627,"compounds":"H2O + N(2)-(4-aminobutanoyl)-L-ornithine <=> 4-aminobutanoate + L-ornithine"}
{"X":57665,"RHEA_ID":56626,"compounds":"2,5-dichlorocyclohexa-2,5-dien-1,4-diol + chloride + H(+) => 2,4,5-trichlorocyclohexa-2,5-dien-1-ol + H2O"}
{"X":57666,"RHEA_ID":61598,"DIRECTION":"RL","MASTER_ID":61596,"metacyc":"RXN-20161","compounds":"[DsbD protein]-disulfide + [thioredoxin]-dithiol => [DsbD protein]-dithiol + [thioredoxin]-disulfide"}
{"X":57667,"RHEA_ID":61195,"compounds":"(E)-4-coumaroyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] <=> CoA + H(+) + myricetin 3-O-[(6-O-(E)-4-coumaroyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]"}
{"X":57668,"RHEA_ID":61076,"compounds":"(-)-minovincinine + acetyl-CoA = (-)-echitovenine + CoA"}
{"X":57669,"RHEA_ID":61077,"compounds":"(-)-minovincinine + acetyl-CoA => (-)-echitovenine + CoA"}
{"X":57670,"RHEA_ID":60910,"compounds":"an N(3)-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in tRNA + S-adenosyl-L-methionine"}
{"X":57671,"RHEA_ID":59904,"compounds":"H2O + NADP(+) + octanal = 2 H(+) + NADPH + octanoate"}
{"X":57672,"RHEA_ID":62053,"compounds":"a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphate + H2O => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)"}
{"X":57673,"RHEA_ID":56756,"compounds":"5 H(+) + 3 O2 + obtusifoliol + 6 reduced [2Fe-2S]-[ferredoxin] = 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":57674,"RHEA_ID":57495,"compounds":"H2O + oxaloacetate + propanoyl-CoA <=> 2-methylcitrate + CoA + H(+)"}
{"X":57675,"RHEA_ID":61607,"compounds":"[DsbA protein]-dithiol + [DsbB protein]-disulfide <=> [DsbA protein]-disulfide + [DsbB protein]-dithiol"}
{"X":57676,"RHEA_ID":62313,"DIRECTION":"LR","MASTER_ID":62312,"metacyc":"RXN-11658","compounds":"salicylate + UDP-alpha-D-glucose => H(+) + salicylate 2-O-beta-D-glucoside + UDP"}
{"X":57677,"RHEA_ID":57499,"compounds":"2-methylcitrate <=> 2-methyl-cis-aconitate + H2O"}
{"X":57678,"RHEA_ID":58852,"compounds":"(6E)-8-oxogeraniol + NAD(+) = (6E)-8-oxogeranial + H(+) + NADH"}
{"X":57679,"RHEA_ID":60180,"compounds":"ATP + D-fructose(out) + H2O = ADP + D-fructose(in) + H(+) + phosphate"}
{"X":57680,"RHEA_ID":60637,"compounds":"N-(dodecanoyl)-sphing-4-enine-1-phosphocholine => choline + N-dodecanoyl-sphing-4-enine-1,3-cyclic phosphate"}
{"X":57681,"RHEA_ID":56764,"DIRECTION":"UN","MASTER_ID":56764,"ec":"1.14.20.14","compounds":"12-epi-fischerindole U + 2-oxoglutarate + chloride + H(+) + O2 = 12-epi-fischerindole G + CO2 + H2O + succinate"}
{"X":57682,"RHEA_ID":60225,"DIRECTION":"LR","MASTER_ID":60224,"metacyc":"RXN-20640","compounds":"2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 2 O2 => 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + 2 succinate"}
{"X":57683,"RHEA_ID":61089,"DIRECTION":"LR","MASTER_ID":61088,"metacyc":"RXN-7775","compounds":"(S)-eriodictyol + 2-oxoglutarate + O2 => (2R,3R)-dihydroquercetin + CO2 + succinate"}
{"X":57684,"RHEA_ID":59788,"compounds":"H2O + NAD(+) + pseudopaline = (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADH"}
{"X":57685,"RHEA_ID":59918,"compounds":"(2E)-octenoate + 2 H(+) + NADPH => (2E)-octenal + H2O + NADP(+)"}
{"X":57686,"RHEA_ID":61622,"compounds":"[(1->2)-beta-D-mannosyl](n+1) + GDP + H(+) => [(1->2)-beta-D-mannosyl](n) + GDP-alpha-D-mannose"}
{"X":57687,"RHEA_ID":57917,"compounds":"ATP + L-aspartyl-tRNA(Asn) => 4-phosphooxy-L-aspartyl-tRNA(Asn) + ADP + H(+)"}
{"X":57688,"RHEA_ID":61757,"DIRECTION":"LR","MASTER_ID":61756,"metacyc":"RXN-13517","compounds":"stevioside + UDP-alpha-D-glucose => H(+) + rebaudioside A + UDP"}
{"X":57689,"RHEA_ID":58329,"compounds":"(Z)-non-6-en-1-ol + NADP(+) => (Z)-non-6-enal + H(+) + NADPH"}
{"X":57690,"RHEA_ID":60652,"compounds":"an N-(acyl)-sphingosylphosphocholine = an N-(acyl)-sphingosyl-1,3-cyclic phosphate + choline"}
{"X":57691,"RHEA_ID":58247,"compounds":"H2O + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] <=> ADP-D-ribose + L-lysyl-[protein]"}
{"X":57692,"RHEA_ID":57885,"compounds":"diphosphate + H2O + Na(+)(in) => H(+) + Na(+)(out) + 2 phosphate"}
{"X":57693,"RHEA_ID":62330,"compounds":"(+)-malbrancheamide + FADH2 => (+)-isomalbrancheamide B + chloride + FAD + 2 H(+)"}
{"X":57694,"RHEA_ID":58621,"compounds":"N-decanoyl-(2S)-hydroxyglycine => decanamide + glyoxylate"}
{"X":57695,"RHEA_ID":59799,"compounds":"dodecanoyl-CoA + L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein] <=> CoA + H(+) + N(6)-dodecanoyl-L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein]"}
{"X":57696,"RHEA_ID":62549,"compounds":"a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + UDP-alpha-D-galactose => beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + H(+) + UDP"}
{"X":57697,"RHEA_ID":59938,"compounds":"3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA + H(+) => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O"}
{"X":57698,"RHEA_ID":58792,"compounds":"ATP + Fe(III)-petrobactin(out) + H2O = ADP + Fe(III)-petrobactin(in) + H(+) + phosphate"}
{"X":57699,"RHEA_ID":59803,"compounds":"decanoyl-CoA + L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein] <=> CoA + H(+) + N(6)-decanoyl-L-lysyl-/S-(2E,6E)-farnesyl-L-cysteinyl-[protein]"}
{"X":57700,"RHEA_ID":57893,"compounds":"a quinone + 5 H(+)(in) + NADPH => a quinol + 4 H(+)(out) + NADP(+)"}
{"X":57701,"RHEA_ID":61513,"compounds":"malvidin + UDP-alpha-D-glucose => malvidin 3-O-beta-D-glucoside + UDP"}
{"X":57702,"RHEA_ID":59128,"DIRECTION":"UN","MASTER_ID":59128,"ec":"6.3.2.55","compounds":"(S)-2,3-diaminopropanoate + 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + ATP = 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + AMP + diphosphate"}
{"X":57703,"RHEA_ID":61475,"compounds":"a sphingoid base + hexadecanoyl-CoA <=> an N-hexadecanoyl-sphingoid base + CoA + H(+)"}
{"X":57704,"RHEA_ID":59808,"compounds":"L-tyrosine = D-tyrosine"}
{"X":57705,"RHEA_ID":56788,"compounds":"apo-[corrinoid adenosyltransferase] + cob(II)alamin = cob(II)alamin--[corrinoid adenosyltransferase]"}
{"X":57706,"RHEA_ID":60208,"DIRECTION":"UN","MASTER_ID":60208,"ec":"1.14.11.67","compounds":"3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 O2 = 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate"}
{"X":57707,"RHEA_ID":61477,"DIRECTION":"LR","MASTER_ID":61476,"metacyc":"RXN-20392","compounds":"a sphingoid base + octadecanoyl-CoA => an N-octadecanoyl-sphingoid base + CoA + H(+)"}
{"X":57708,"RHEA_ID":59812,"compounds":"hexadecanoyl-CoA + N-terminal glycyl-[protein] = CoA + H(+) + N-terminal N(6)-hexadecanoylglycyl-[protein]"}
{"X":57709,"RHEA_ID":58638,"compounds":"(9Z)-octadecenamide + glyoxylate => N-(9Z-octadecenoyl)-(2S)-hydroxyglycine"}
{"X":57710,"RHEA_ID":60213,"DIRECTION":"LR","MASTER_ID":60212,"metacyc":"RXN-20622","compounds":"2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + O2 => CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + succinate"}
{"X":57711,"RHEA_ID":61969,"compounds":"a 1-O-(9Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + AH2 + O2 => A + a 1-O-(1Z,9Z-octadecadienyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 H2O"}
{"X":57712,"RHEA_ID":58641,"compounds":"a 5'-(5'-phospho)-ribonucleoside-RNA + 2 S-adenosyl-L-methionine => a 5'-(5'-bisphosphomethyl)-ribonucleoside-RNA + 2 S-adenosyl-L-homocysteine"}
{"X":57713,"RHEA_ID":57535,"compounds":"5'-end ribonucleotide-RNA + ATP + H(+) <=> adenosine-5'-diphospho-5'-ribonucleotide-RNA + diphosphate"}
{"X":57714,"RHEA_ID":56434,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O"}
{"X":57715,"RHEA_ID":59823,"compounds":"2 ATP <=> adenosine 3'-diphosphate,5'-triphosphate + AMP"}
{"X":57716,"RHEA_ID":61488,"compounds":"cytidine(50) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(50) in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":57717,"RHEA_ID":56437,"compounds":"1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O => 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":57718,"RHEA_ID":62354,"compounds":"H2O + NADP(+) + notoamide D => H(+) + NADPH + notoamide E + O2"}
{"X":57719,"RHEA_ID":60220,"compounds":"2-oxoglutarate + N(6)-methyl-L-lysyl(4)-[histone H3] + O2 = CO2 + formaldehyde + L-lysyl(4)-[histone H3] + succinate"}
{"X":57720,"RHEA_ID":56440,"compounds":"1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate"}
{"X":57721,"RHEA_ID":59833,"DIRECTION":"LR","MASTER_ID":59832,"metacyc":"RXN-12005","compounds":"ATP + N(6)-(D-fructosyl)-L-lysyl-[protein] => ADP + H(+) + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein]"}
{"X":57722,"RHEA_ID":60765,"compounds":"(1R,3R)-pyrethroyl-CoA + (Z,S)-cinerolone => cinerin II + CoA"}
{"X":57723,"RHEA_ID":59835,"compounds":"ATP + N(6)-(D-fructosyl)-L-lysyl-[protein] <=> ADP + H(+) + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein]"}
{"X":57724,"RHEA_ID":62742,"compounds":"1-hydroxy-3-(1H-indol-3-ylmethyl)-6H,7H,8H-5lambda5-pyrrolo[1,2-a]pyrazin-5-ylium + AH2 => (8aS)-3-[(1H-indol-3-yl)methyl]-1H,2H,6H,7H,8H,8aH-pyrrolo[1,2-a]pyrazin-1-one + A + H(+)"}
{"X":57725,"RHEA_ID":62756,"compounds":"4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":57726,"RHEA_ID":60224,"DIRECTION":"UN","MASTER_ID":60224,"ec":"1.14.11.68","compounds":"2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + 2 succinate"}
{"X":57727,"RHEA_ID":62152,"compounds":"dGMP + dTTP = dGDP + dTDP"}
{"X":57728,"RHEA_ID":57629,"compounds":"3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate => H2O + ML-236C carboxylate"}
{"X":57729,"RHEA_ID":58490,"compounds":"H2O + NAD(+) + succinate semialdehyde + trimethylamine => 4-(trimethylamino)butanoate + H(+) + NADH + O2"}
{"X":57730,"RHEA_ID":60733,"compounds":"H2O + NADP(+) + perillyl aldehyde => 2 H(+) + NADPH + perillate"}
{"X":57731,"RHEA_ID":62762,"compounds":"4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}
{"X":57732,"RHEA_ID":58780,"compounds":"a 5'-triphospho-guanosine-ribonucleotide-snRNA + S-adenosyl-L-methionine = a 5'-methyltriphosphate-guanosine-ribonucleotide-snRNA + S-adenosyl-L-homocysteine"}
{"X":57733,"RHEA_ID":58293,"compounds":"25-substituted-cholesterol + beta-D-glucosyl-N-dodecanoylsphing-4E-enine => 25-substituted-cholesteryl beta-D-glucoside + N-dodecanoylsphing-4-enine"}
{"X":57734,"RHEA_ID":61993,"DIRECTION":"LR","MASTER_ID":61992,"metacyc":"RXN-20615","compounds":"N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine"}
{"X":57735,"RHEA_ID":57556,"compounds":"(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + zealexin A1"}
{"X":57736,"RHEA_ID":62373,"DIRECTION":"LR","MASTER_ID":62372,"metacyc":"2.1.1.74-RXN","compounds":"(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + uridine(54) in tRNA => (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NADP(+)"}
{"X":57737,"RHEA_ID":62599,"compounds":"(S)-8-oxocitronellyl enol + NAD(+) <=> (6E)-8-oxogeranial + H(+) + NADH"}
{"X":57738,"RHEA_ID":62207,"compounds":"1-propanol + 2 [Fe(III)cytochrome c] <=> 2 [Fe(II)cytochrome c] + 2 H(+) + propanal"}
{"X":57739,"RHEA_ID":60854,"compounds":"a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-homocysteine => a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine"}
{"X":57740,"RHEA_ID":62405,"DIRECTION":"LR","MASTER_ID":62404,"metacyc":"RXN-20650","compounds":"(R)-2-hydroxyhexadecanoate + O2 => CO2 + H2O + pentadecanoate"}
{"X":57741,"RHEA_ID":58339,"compounds":"a 4-hydroxynonen-1-ol + NADP(+) <=> a 4-hydroxynonenal + H(+) + NADPH"}
{"X":57742,"RHEA_ID":60704,"compounds":"a 1-acyl-sn-glycero-3-phosphoethanolamine = a 1-acyl-sn-glycero-2,3-cyclic phosphate + ethanolamine"}
{"X":57743,"RHEA_ID":60706,"compounds":"a 1-acyl-sn-glycero-2,3-cyclic phosphate + ethanolamine => a 1-acyl-sn-glycero-3-phosphoethanolamine"}
{"X":57744,"RHEA_ID":60858,"compounds":"a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-homocysteine => a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine"}
{"X":57745,"RHEA_ID":61393,"compounds":"ATP + N(6)-(D-psicosyl)-L-lysyl-[protein] => ADP + H(+) + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein]"}
{"X":57746,"RHEA_ID":61521,"compounds":"AH2 + dopamine => 3-tyramine + A + H2O"}
{"X":57747,"RHEA_ID":62672,"compounds":"a 2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-O-methyladenosine in U2 snRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":57748,"RHEA_ID":60862,"compounds":"a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-adenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine"}
{"X":57749,"RHEA_ID":59998,"DIRECTION":"RL","MASTER_ID":59996,"metacyc":"RXN-19882","compounds":"reduced [electron-transfer flavoprotein] + trans-cinnamate => 3-phenylpropanoate + H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":57750,"RHEA_ID":62009,"compounds":"alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP + H(+)"}
{"X":57751,"RHEA_ID":62136,"DIRECTION":"UN","MASTER_ID":62136,"metacyc":"RXN-17140","compounds":"dGMP + GTP = dGDP + GDP"}
{"X":57752,"RHEA_ID":58186,"compounds":"(14E,18E)-lycopadiene + 2 diphosphate + NADP(+) => H(+) + NADPH + 2 phytyl diphosphate"}
{"X":57753,"RHEA_ID":61886,"compounds":"1-O-methyl-9-hydroperoxy-20-hydroxy-(5Z,7E,11Z,14Z)-eicosatetraenoate => 1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2"}
{"X":57754,"RHEA_ID":58354,"compounds":"CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate => 2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + O2"}
{"X":57755,"RHEA_ID":59212,"compounds":"holo-[(hydroxy)phthioceranic acid synthase] + octadecanoyl-AMP = AMP + H(+) + octadecanoyl-[(hydroxy)phthioceranic acid synthase]"}
{"X":57756,"RHEA_ID":61283,"compounds":"4-aminobutanoate + H2O + O2 <=> H2O2 + NH4(+) + succinate semialdehyde"}
{"X":57757,"RHEA_ID":58811,"compounds":"2',3'-cGAMP + 2 H2O <=> AMP + GMP + 2 H(+)"}
{"X":57758,"RHEA_ID":56960,"compounds":"a ribonucleoside 5'-triphosphate + pyruvate = a ribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate"}
{"X":57759,"RHEA_ID":61449,"DIRECTION":"LR","MASTER_ID":61448,"metacyc":"RXN-17969","compounds":"H(+) + NADPH + O2 + tigecycline => 11a-hydroxytigecycline + H2O + NADP(+)"}
{"X":57760,"RHEA_ID":60381,"compounds":"L-dehydroascorbate(out) => L-dehydroascorbate(in)"}
{"X":57761,"RHEA_ID":58439,"compounds":"4-methylpentan-1-ol + NADP(+) <=> 4-methylpentanal + H(+) + NADPH"}
{"X":57762,"RHEA_ID":61686,"compounds":"glycerol + H(+) + phosphocholine => glycero-2-phosphocholine + H2O"}
{"X":57763,"RHEA_ID":58363,"compounds":"2-oxoglutarate + L-lysyl-[protein] + O2 <=> (5S)-5-hydroxy-L-lysyl-[protein] + CO2 + succinate"}
{"X":57764,"RHEA_ID":58077,"compounds":"1-(11Z-eicosenoyl)-glycerol + H2O => (11Z)-eicosenoate + glycerol + H(+)"}
{"X":57765,"RHEA_ID":61294,"compounds":"2-dehydropantoate + H(+) + NADH => (R)-pantoate + NAD(+)"}
{"X":57766,"RHEA_ID":62690,"compounds":"2 H2O + 2 ustilaginoidin A => 4 norrubrofusarin + O2"}
{"X":57767,"RHEA_ID":57999,"compounds":"(20S)-protopanaxadiol + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rh2 + H(+) + UDP"}
{"X":57768,"RHEA_ID":61981,"compounds":"H(+) + NADPH + ubiquinone-10 => NADP(+) + ubiquinol-10"}
{"X":57769,"RHEA_ID":58613,"compounds":"2 L-ascorbate + N-octanoylglycine + O2 => H2O + 2 monodehydro-L-ascorbate radical + N-octanoyl-(2S)-hydroxyglycine"}
{"X":57770,"RHEA_ID":62541,"compounds":"2 [Fe(II)cytochrome c] + 3 H(+) + ouabain => 2 [Fe(III)cytochrome c] + dihydroouabain"}
{"X":57771,"RHEA_ID":58331,"compounds":"(Z)-non-6-en-1-ol + NADP(+) <=> (Z)-non-6-enal + H(+) + NADPH"}
{"X":57772,"RHEA_ID":58701,"compounds":"FADH2-C4alpha-hydroperoxide + NADPH + rifampicin => FADH2 + H(+) + H2O + NADP(+) + rifampicin hemiaminal"}
{"X":57773,"RHEA_ID":61760,"compounds":"rebaudioside B + UDP-alpha-D-glucose = rebaudioside A + UDP"}
{"X":57774,"RHEA_ID":62034,"compounds":"a 2-acyl-sn-glycero-3-phosphoglycerol + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphoglycerol + H2O"}
{"X":57775,"RHEA_ID":56495,"compounds":"hederagenin + O2 + reduced [NADPH--hemoprotein reductase] <=> gypsogenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":57776,"RHEA_ID":60025,"compounds":"(R,R)-chrysanthemyl diphosphate + H2O => (R,R)-chrysanthemol + diphosphate"}
{"X":57777,"RHEA_ID":57346,"compounds":"3-hydroxy-4-methyl-D-kynurenine + H(+) + S-adenosyl-L-homocysteine => 3-hydroxy-D-kynurenine + S-adenosyl-L-methionine"}
{"X":57778,"RHEA_ID":62370,"compounds":"Fe(2+)(in) + 2 hydrogencarbonate(in) => Fe(2+)(out) + 2 hydrogencarbonate(out)"}
{"X":57779,"RHEA_ID":60801,"DIRECTION":"LR","MASTER_ID":60800,"metacyc":"RXN1F-167","compounds":"2-oxoglutarate + gibberellin A53 + O2 => CO2 + gibberellin A44 + succinate"}
{"X":57780,"RHEA_ID":60147,"compounds":"ATP + L-glutamate + L-glutamyl-[protein] <=> ADP + H(+) + L-gamma-glutamyl-L-glutamyl-[protein] + phosphate"}
{"X":57781,"RHEA_ID":62553,"compounds":"beta-D-glucosylceramide + UDP-alpha-D-galactose => beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H(+) + UDP"}
{"X":57782,"RHEA_ID":56542,"compounds":"1,2-dihexanoyl-3-(9Z-octadecenoyl)-sn-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1,2-dihexanoyl-sn-glycerol"}
{"X":57783,"RHEA_ID":58709,"compounds":"rifampicin ortho-naphthoquinone carboxamide => rifampicin para-naphthoquinone carboxamide"}
{"X":57784,"RHEA_ID":62557,"DIRECTION":"LR","MASTER_ID":62556,"metacyc":"RXN-20409","compounds":"3,4-dihydroxyphenylacetate + H(+) => 4-methylcatechol + CO2"}
{"X":57785,"RHEA_ID":60031,"compounds":"(2E)-geranyl diphosphate + H2O <=> 4-terpineol + diphosphate"}
{"X":57786,"RHEA_ID":61646,"compounds":"2 [Fe(III)-cytochrome b5] + H2O + L-arginine => 2 [Fe(II)-cytochrome b5] + 2 H(+) + N(omega)-hydroxy-L-arginine"}
{"X":57787,"RHEA_ID":58019,"compounds":"8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":57788,"RHEA_ID":60037,"DIRECTION":"LR","MASTER_ID":60036,"metacyc":"RXN-19540","compounds":"H2O + N(2)-(3-hydroxy-3-methylhexanoyl)-L-glutaminate => 3-hydroxy-3-methylhexanoate + L-glutamine"}
{"X":57789,"RHEA_ID":59899,"compounds":"ATP + L-glutamate + L-propargylglycine <=> ADP + H(+) + L-gamma-glutamyl-L-propargylglycine + phosphate"}
{"X":57790,"RHEA_ID":60293,"DIRECTION":"LR","MASTER_ID":60292,"metacyc":"RXN-20618","compounds":"L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine"}
{"X":57791,"RHEA_ID":60035,"compounds":"8-oxo-GTP + H2O <=> 8-oxo-GDP + H(+) + phosphate"}
{"X":57792,"RHEA_ID":58594,"compounds":"1-hexadecanoyl-2-(9-hydroxynonanoyl)-sn-glycero-3-phosphocholine + NADP(+) => 1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH"}
{"X":57793,"RHEA_ID":62306,"compounds":"(+)-premalbrancheamide => 1-hydroxy-3-{[2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine"}
{"X":57794,"RHEA_ID":62094,"compounds":"1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + phosphate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-diphosphate + H2O"}
{"X":57795,"RHEA_ID":60756,"compounds":"(1R,3R)-chrysanthemoyl-CoA + (Z,S)-cinerolone = cinerin I + CoA"}
{"X":57796,"RHEA_ID":61323,"compounds":"(+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + parthenolide"}
{"X":57797,"RHEA_ID":58725,"compounds":"adenosine(4220) in 28S rRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine(4220) in 28S rRNA + S-adenosyl-L-homocysteine"}
{"X":57798,"RHEA_ID":61787,"compounds":"L-allulose <=> keto-L-fructose"}
{"X":57799,"RHEA_ID":60833,"compounds":"a 5'-end triphospho-guanosine in mRNA + H2O => a 5'-end diphospho-guanosine in mRNA + H(+) + phosphate"}
{"X":57800,"RHEA_ID":61937,"compounds":"ATP + cycloheximide(in) + H2O => ADP + cycloheximide(out) + H(+) + phosphate"}
{"X":57801,"RHEA_ID":59512,"compounds":"acetylsalicylate + L-seryl-[protein] = O-acetyl-L-seryl-[protein] + salicylate"}
{"X":57802,"RHEA_ID":59552,"compounds":"N,N',N'',N'''-tetraacetylchitotetraose + O2 = H2O2 + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone"}
{"X":57803,"RHEA_ID":60837,"compounds":"a 5'-end diphospho-adenosine in mRNA + GTP + H(+) => a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + diphosphate"}
{"X":57804,"RHEA_ID":59380,"DIRECTION":"UN","MASTER_ID":59380,"ec":"1.3.1.121","compounds":"4-amino-4-deoxyprephenate + NAD(+) = 3-(4-aminophenyl)pyruvate + CO2 + H(+) + NADH"}
{"X":57805,"RHEA_ID":58365,"compounds":"a medium-chain primary fatty alcohol + NADP(+) => a medium-chain fatty aldehyde + H(+) + NADPH"}
{"X":57806,"RHEA_ID":62358,"compounds":"8-oxo-GMP + H(+) + phosphate => 8-oxo-GDP + H2O"}
{"X":57807,"RHEA_ID":58240,"compounds":"H2O + S-(ADP-D-ribosyl)-L-cysteinyl-[protein] = ADP-D-ribose + L-cysteinyl-[protein]"}
{"X":57808,"RHEA_ID":60135,"compounds":"a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2 <=> a (8S,9S)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate"}
{"X":57809,"RHEA_ID":62357,"DIRECTION":"LR","MASTER_ID":62356,"reactome":"R-HSA-2395873.3","compounds":"8-oxo-GDP + H2O => 8-oxo-GMP + H(+) + phosphate"}
{"X":57810,"RHEA_ID":62655,"compounds":"acetyl-CoA + 6 H(+) + 6 malonyl-CoA <=> 6 CO2 + 7 CoA + H2O + YWA1"}
{"X":57811,"RHEA_ID":58994,"compounds":"cinnamate + H(+) + H2O2 => cinnamaldehyde + H2O + O2"}
{"X":57812,"RHEA_ID":57633,"compounds":"ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + ML-236A carboxylate + oxidized [NADPH--hemoprotein reductase]"}
{"X":57813,"RHEA_ID":58741,"compounds":"H2O + psi-UTP => diphosphate + H(+) + psi-UMP"}
{"X":57814,"RHEA_ID":60461,"compounds":"(6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) => (6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)"}
{"X":57815,"RHEA_ID":58495,"compounds":"ATP + Fe(III)-enterobactin(out) + H2O <=> ADP + Fe(III)-enterobactin(in) + H(+) + phosphate"}
{"X":57816,"RHEA_ID":57638,"compounds":"compactin carboxylate + holo-[2-methylbutanoate polyketide synthase] => (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + ML-236A carboxylate"}
{"X":57817,"RHEA_ID":57768,"DIRECTION":"UN","MASTER_ID":57768,"ec":"1.14.12.23","compounds":"2-nitrotoluene + NADH + O2 = 3-methylcatechol + NAD(+) + nitrite"}
{"X":57818,"RHEA_ID":60736,"compounds":"(2E,6E)-farnesal + H2O + NADP(+) = (2E,6E)-farnesoate + 2 H(+) + NADPH"}
{"X":57819,"RHEA_ID":61509,"DIRECTION":"LR","MASTER_ID":61508,"metacyc":"RXN-17675","compounds":"peonidin + UDP-alpha-D-glucose => peonidin 3-O-beta-D-glucoside + UDP"}
{"X":57820,"RHEA_ID":57642,"compounds":"(3-{(1R,2S,6S,8R)-2,8-dimethyl-3-[(E)-prop-1-enyl]-4,5-didehydrodecalin-2-yl}-3-oxopropanoyl)-[equisetin nonaketide synthase] + 8 CO2 + 8 CoA + 6 H2O + 8 NADP(+) + 2 S-adenosyl-L-homocysteine => 14 H(+) + holo-[equisetin nonaketide synthase] + 8 malonyl-CoA + 8 NADPH + 2 S-adenosyl-L-methionine"}
{"X":57821,"RHEA_ID":59989,"compounds":"cyclohexane-1-carbonyl-CoA + NADP(+) => cyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH"}
{"X":57822,"RHEA_ID":57692,"compounds":"2 cob(II)inamide--[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] = 2 cob(I)inamide--[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":57823,"RHEA_ID":58135,"compounds":"A + ajmalicine + O2 + reduced [NADPH--hemoprotein reductase] <=> AH2 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + serpentine"}
{"X":57824,"RHEA_ID":58056,"DIRECTION":"UN","MASTER_ID":58056,"ec":"2.6.1.77","compounds":"hypotaurine + pyruvate = 2-sulfinoacetaldehyde + L-alanine"}
{"X":57825,"RHEA_ID":59943,"compounds":"2-methyloctadecanoyl-CoA + H2O <=> 2-methyloctadecanoate + CoA + H(+)"}
{"X":57826,"RHEA_ID":62001,"compounds":"3 A + protoporphyrinogen IX => 3 AH2 + protoporphyrin IX"}
{"X":57827,"RHEA_ID":62722,"compounds":"betaenone B + 3 H2O + 3 NADP(+) => 3 H(+) + 3 NADPH + 3 O2 + probetaenone I"}
{"X":57828,"RHEA_ID":58756,"compounds":"1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphoethanolamine + H(+) + NADPH = 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphoethanolamine + NADP(+)"}
{"X":57829,"RHEA_ID":62569,"DIRECTION":"LR","MASTER_ID":62568,"metacyc":"RXN-19568","compounds":"H2O + S-benzyl-L-cysteinylglycine => glycine + S-benzyl-L-cysteine"}
{"X":57830,"RHEA_ID":57275,"compounds":"a 2'-deoxyguanosine in DNA + methylglyoxal <=> an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA"}
{"X":57831,"RHEA_ID":56551,"compounds":"H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine"}
{"X":57832,"RHEA_ID":56672,"DIRECTION":"UN","MASTER_ID":56672,"ec":"1.3.1.117","compounds":"dihydro-4-coumaroyl-CoA + NADP(+) = (E)-4-coumaroyl-CoA + H(+) + NADPH"}
{"X":57833,"RHEA_ID":62345,"DIRECTION":"LR","MASTER_ID":62344,"metacyc":"RXN-16105","compounds":"6-hydroxydeoxybrevianamide E + dimethylallyl diphosphate => diphosphate + notoamide S"}
{"X":57834,"RHEA_ID":61279,"compounds":"H2O + L-ornithine + O2 <=> 5-amino-2-oxopentanoate + H2O2 + NH4(+)"}
{"X":57835,"RHEA_ID":60080,"compounds":"4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADH + O2 = 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + H2O + NAD(+)"}
{"X":57836,"RHEA_ID":58765,"compounds":"1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphate + H(+) + NADPH => 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphate + NADP(+)"}
{"X":57837,"RHEA_ID":62734,"compounds":"(+)-isomalbrancheamide D + FADH2 => (+)-isomalbrancheamide B + bromide + FAD + 2 H(+)"}
{"X":57838,"RHEA_ID":61851,"compounds":"cholesterol + UDP-alpha-D-glucose <=> cholesteryl 3-beta-D-glucoside + H(+) + UDP"}
{"X":57839,"RHEA_ID":62524,"compounds":"cytidine(839) in 12S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(839) in 12S rRNA + S-adenosyl-L-homocysteine"}
{"X":57840,"RHEA_ID":59968,"compounds":"L-threonyl-[protein] + octanoyl-CoA = CoA + O-octanoyl-L-threonyl-[protein]"}
{"X":57841,"RHEA_ID":59553,"compounds":"N,N',N'',N'''-tetraacetylchitotetraose + O2 => H2O2 + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone"}
{"X":57842,"RHEA_ID":62353,"DIRECTION":"LR","MASTER_ID":62352,"metacyc":"RXN-16109","compounds":"H(+) + NADPH + notoamide E + O2 => H2O + NADP(+) + notoamide D"}
{"X":57843,"RHEA_ID":58728,"compounds":"adenosine in rRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine in rRNA + S-adenosyl-L-homocysteine"}
{"X":57844,"RHEA_ID":58773,"compounds":"1-O-hexadecyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH => 1-O-hexadecyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)"}
{"X":57845,"RHEA_ID":60226,"compounds":"2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + 2 succinate => 2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 2 O2"}
{"X":57846,"RHEA_ID":60011,"compounds":"a tRNA precursor + 2 CTP <=> a tRNA with a 3' CC end + 2 diphosphate"}
{"X":57847,"RHEA_ID":61493,"DIRECTION":"LR","MASTER_ID":61492,"metacyc":"RXN-20365","compounds":"a sphingoid base + ultra-long-chain fatty acyl-CoA => an N-(ultra-long-chain-acyl)-sphingoid base + CoA + H(+)"}
{"X":57848,"RHEA_ID":62193,"compounds":"O2 + peregrinol + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + labd-13Z-ene-9,15,16-triol + oxidized [NADPH--hemoprotein reductase]"}
{"X":57849,"RHEA_ID":58281,"compounds":"4 ATP => cyclic tetraadenylate + 4 diphosphate"}
{"X":57850,"RHEA_ID":59915,"compounds":"(E)-4-hydroxynon-2-enal + H2O + NADP(+) <=> (E)-4-hydroxynon-2-enoate + 2 H(+) + NADPH"}
{"X":57851,"RHEA_ID":60394,"compounds":"Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+) => Fe(III)-C-5-deoxy-beta-D-glucosyl-enterobactin + H2O"}
{"X":57852,"RHEA_ID":58825,"DIRECTION":"LR","MASTER_ID":58824,"metacyc":"RXN-20210","compounds":"4 H(+) + luteothin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => aureothin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":57853,"RHEA_ID":58533,"compounds":"15alpha-stemmadenine intermediate I + H2O => akuammicine + formate + H(+)"}
{"X":57854,"RHEA_ID":56573,"compounds":"beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-alpha-D-galactose => globoside Gb3Cer + H(+) + UDP"}
{"X":57855,"RHEA_ID":62595,"compounds":"(S)-8-oxocitronellyl enol + NADP(+) <=> (6E)-8-oxogeranial + H(+) + NADPH"}
{"X":57856,"RHEA_ID":58169,"DIRECTION":"LR","MASTER_ID":58168,"metacyc":"RXN-20044","compounds":"(2E,6E)-farnesyl diphosphate => (-)-5-epi-eremophilene + diphosphate"}
{"X":57857,"RHEA_ID":59985,"DIRECTION":"LR","MASTER_ID":59984,"metacyc":"RXN-19541","compounds":"an N(2)-acyl-L-glutamine + H2O => a carboxylate + L-glutamine"}
{"X":57858,"RHEA_ID":62548,"compounds":"a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + UDP-alpha-D-galactose = beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + H(+) + UDP"}
{"X":57859,"RHEA_ID":60319,"compounds":"N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":57860,"RHEA_ID":61727,"compounds":"a D-glucoside + NAD(+) <=> a 3-dehydro-D-glucoside + H(+) + NADH"}
{"X":57861,"RHEA_ID":59398,"compounds":"D-leucine => L-leucine"}
{"X":57862,"RHEA_ID":62210,"compounds":"3-hydroxybenzyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-methylphenol + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":57863,"RHEA_ID":62603,"compounds":"(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 <=> 5-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate"}
{"X":57864,"RHEA_ID":60324,"DIRECTION":"UN","MASTER_ID":60324,"ec":"2.1.1.359","compounds":"L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine"}
{"X":57865,"RHEA_ID":58177,"DIRECTION":"LR","MASTER_ID":58176,"metacyc":"RXN-19160","compounds":"2 all-trans-geranylgeranyl diphosphate + H(+) + NADPH => all-trans-lycopaoctaene + 2 diphosphate + NADP(+)"}
{"X":57866,"RHEA_ID":60071,"compounds":"4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H(+) + 3 NADH + 3 O2 <=> 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 4 H2O + 3 NAD(+)"}
{"X":57867,"RHEA_ID":58545,"compounds":"2 L-ascorbate + N-tetradecanoylglycine + O2 => H2O + 2 monodehydro-L-ascorbate radical + N-tetradecanoyl-(2S)-hydroxyglycine"}
{"X":57868,"RHEA_ID":59285,"compounds":"beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O => D-glucose + N-octadecanoylsphing-4-enine"}
{"X":57869,"RHEA_ID":61275,"compounds":"H2O + L-2-aminopentanoate + O2 <=> 2-oxopentanoate + H2O2 + NH4(+)"}
{"X":57870,"RHEA_ID":57569,"DIRECTION":"LR","MASTER_ID":57568,"metacyc":"RXN-9371","compounds":"7-deoxyloganetic alcohol + O2 + reduced [NADPH--hemoprotein reductase] => 7-deoxyloganetic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":57871,"RHEA_ID":58431,"compounds":"(E,E)-2,4-hexadien-1-ol + NADP(+) <=> (E,E)-2,4-hexadienal + H(+) + NADPH"}
{"X":57872,"RHEA_ID":62434,"compounds":"a 3-[(3S)-3-amino-3-carboxypropyl]-uridine in tRNA + H(+) + S-methyl-5'-thioadenosine => a uridine in tRNA + S-adenosyl-L-methionine"}
{"X":57873,"RHEA_ID":57701,"DIRECTION":"LR","MASTER_ID":57700,"metacyc":"RXN-18518","compounds":"a 2-demethylmenaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine => 5'-deoxyadenosine + a 2-demethyl-8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine"}
{"X":57874,"RHEA_ID":57613,"compounds":"20 H(+) + holo-[compactin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH => 9 CO2 + 9 CoA + dihydro-ML-236C-[compactin nonaketide synthase] + 6 H2O + 11 NADP(+)"}
{"X":57875,"RHEA_ID":57614,"compounds":"9 CO2 + 9 CoA + dihydro-ML-236C-[compactin nonaketide synthase] + 6 H2O + 11 NADP(+) => 20 H(+) + holo-[compactin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH"}
{"X":57876,"RHEA_ID":58435,"compounds":"(E)-4-oxonon-2-en-1-ol + NADP(+) <=> (E)-4-oxonon-2-enal + H(+) + NADPH"}
{"X":57877,"RHEA_ID":61890,"compounds":"diosgenin 3-beta-D-glucoside + H(+) + UDP => diosgenin + UDP-alpha-D-glucose"}
{"X":57878,"RHEA_ID":60002,"compounds":"formate + 2 H(+) + phosphate => hydroxymethylphosphonate + O2"}
{"X":57879,"RHEA_ID":61123,"compounds":"kaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + 2 H2O + myricetin + 2 oxidized [NADPH--hemoprotein reductase]"}
{"X":57880,"RHEA_ID":56800,"compounds":"apo-[corrinoid adenosyltransferase] + cob(II)yrinate a,c diamide = cob(II)yrinate a,c diamide--[corrinoid adenosyltransferase]"}
{"X":57881,"RHEA_ID":61746,"compounds":"stevioside + UDP => steviolbioside + UDP-alpha-D-glucose"}
{"X":57882,"RHEA_ID":61973,"compounds":"1-O-(13-methyltetradecyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + AH2 + O2 => 1-O-(1Z-13-methyltetradecenyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + A + 2 H2O"}
{"X":57883,"RHEA_ID":59420,"compounds":"H2O + methylamine + O2 = formaldehyde + H2O2 + NH4(+)"}
{"X":57884,"RHEA_ID":62317,"DIRECTION":"LR","MASTER_ID":62316,"metacyc":"RXN-11659","compounds":"salicylate + UDP-alpha-D-glucose => 1-O-salicyl-beta-D-glucose + UDP"}
{"X":57885,"RHEA_ID":58362,"compounds":"(5S)-5-hydroxy-L-lysyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-lysyl-[protein] + O2"}
{"X":57886,"RHEA_ID":58858,"compounds":"(6E)-8-oxogeraniol + H(+) + NADH => (6E)-8-hydroxygeraniol + NAD(+)"}
{"X":57887,"RHEA_ID":58610,"compounds":"H2O + 2 monodehydro-L-ascorbate radical + N-decanoyl-(2S)-hydroxyglycine => 2 L-ascorbate + N-decanoylglycine + O2"}
{"X":57888,"RHEA_ID":58733,"compounds":"5-methyl-CTP + H2O => 5-methyl-CMP + diphosphate + H(+)"}
{"X":57889,"RHEA_ID":60361,"compounds":"FMN + H(+) + oxidized F420-0 => dehydro F420-0 + FMNH2"}
{"X":57890,"RHEA_ID":62065,"compounds":"2-deoxy-D-glucose 6-phosphate + NAD(+) => 2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADH"}
{"X":57891,"RHEA_ID":59733,"compounds":"biotinyl-5'-AMP + L-lysyl-[protein] => AMP + 2 H(+) + N(6)-biotinyl-L-lysyl-[protein]"}
{"X":57892,"RHEA_ID":62540,"compounds":"2 [Fe(II)cytochrome c] + 3 H(+) + ouabain = 2 [Fe(III)cytochrome c] + dihydroouabain"}
{"X":57893,"RHEA_ID":60021,"compounds":"(2E,6E)-farnesyl diphosphate => diphosphate + sesquisabinene A"}
{"X":57894,"RHEA_ID":60606,"compounds":"1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + choline => 1-tetradecanoyl-sn-glycero-3-phosphocholine"}
{"X":57895,"RHEA_ID":57725,"DIRECTION":"LR","MASTER_ID":57724,"metacyc":"RXN-19736","compounds":"H(+) + 2 Na(+)(in) + oxaloacetate => CO2 + 2 Na(+)(out) + pyruvate"}
{"X":57896,"RHEA_ID":60023,"compounds":"(2E,6E)-farnesyl diphosphate <=> diphosphate + sesquisabinene A"}
{"X":57897,"RHEA_ID":58335,"compounds":"(E)-non-2-en-1-ol + NADP(+) <=> (E)-non-2-enal + H(+) + NADPH"}
{"X":57898,"RHEA_ID":61386,"compounds":"5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(out) + ADP + H(+) + phosphate => 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(in) + ATP + H2O"}
{"X":57899,"RHEA_ID":60360,"compounds":"FMN + H(+) + oxidized F420-0 = dehydro F420-0 + FMNH2"}
{"X":57900,"RHEA_ID":61469,"compounds":"a cytidine in tRNA + S-adenosyl-L-methionine => a 5-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":57901,"RHEA_ID":61725,"compounds":"a D-glucoside + NAD(+) => a 3-dehydro-D-glucoside + H(+) + NADH"}
{"X":57902,"RHEA_ID":61484,"compounds":"a cytidine in rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":57903,"RHEA_ID":57025,"compounds":"apulose 4-phosphate + D-glyceraldehyde 3-phosphate => D-xylulose 5-phosphate + dihydroxyacetone phosphate"}
{"X":57904,"RHEA_ID":58301,"compounds":"25-substituted-cholesterol + beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine => 25-substituted-cholesteryl beta-D-glucoside + N-octadecanoylsphing-4-enine"}
{"X":57905,"RHEA_ID":62338,"compounds":"adenosine 3'-diphosphate,5'-phosphate + AMP + H(+) => AMP + ATP"}
{"X":57906,"RHEA_ID":58795,"compounds":"ATP + Fe(III)-petrobactin(out) + H2O <=> ADP + Fe(III)-petrobactin(in) + H(+) + phosphate"}
{"X":57907,"RHEA_ID":60665,"DIRECTION":"LR","MASTER_ID":60664,"metacyc":"RXN-7703","compounds":"H2O + NADPH => NADH + phosphate"}
{"X":57908,"RHEA_ID":59806,"compounds":"D-phenylalanine => L-phenylalanine"}
{"X":57909,"RHEA_ID":58509,"compounds":"(3Z)-2-oxo-4-carboxy-3-hexenedioate + H2O => (2S)-2-hydroxy-4-oxobutane-1,2,4-tricarboxylate"}
{"X":57910,"RHEA_ID":60425,"DIRECTION":"LR","MASTER_ID":60424,"metacyc":"RXN-20455","compounds":"(2E,6E)-farnesyl diphosphate + H2O => diphosphate + valerianol"}
{"X":57911,"RHEA_ID":56630,"compounds":"chloride + 2 H(+) + maleylacetate => 5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H2O"}
{"X":57912,"RHEA_ID":62726,"compounds":"(+)-isomalbrancheamide C + FADH2 => (+)-premalbrancheamide + bromide + FAD + 2 H(+)"}
{"X":57913,"RHEA_ID":61318,"compounds":"germacra-1(10),4,11(13)-trien-12-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-al + O2 + reduced [NADPH--hemoprotein reductase]"}
{"X":57914,"RHEA_ID":60825,"compounds":"H2O + P(1),P(2)-bis(5'-adenosyl) diphosphate => 2 AMP + 2 H(+)"}
{"X":57915,"RHEA_ID":58650,"compounds":"H(+) + rifamycin SV ortho-naphthoquinone carboxamide => rifamycin SV hemiaminal"}
{"X":57916,"RHEA_ID":58977,"compounds":"H2O + malonaldehyde + O2 => 3-oxopropanoate + H(+) + H2O2"}
{"X":57917,"RHEA_ID":59903,"compounds":"2-oxoglutarate + L-gamma-glutamyl-L-propargylglycine + O2 <=> CO2 + L-gamma-glutamyl-(3R)-L-beta-ethynylserine + succinate"}
{"X":57918,"RHEA_ID":60045,"compounds":"beta-D-Gal-(1<->1')-Cer + UDP-alpha-D-galactose => alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer + H(+) + UDP"}
{"X":57919,"RHEA_ID":58724,"compounds":"adenosine(4220) in 28S rRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(4220) in 28S rRNA + S-adenosyl-L-homocysteine"}
{"X":57920,"RHEA_ID":60216,"compounds":"2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + O2 = CO2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3] + succinate"}
{"X":57921,"RHEA_ID":61489,"compounds":"cytidine(50) in tRNA + S-adenosyl-L-methionine => 5-methylcytidine(50) in tRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":57922,"RHEA_ID":60193,"DIRECTION":"LR","MASTER_ID":60192,"metacyc":"RXN-20629","compounds":"2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + O2 => CO2 + formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + succinate"}
{"X":57923,"RHEA_ID":58644,"compounds":"N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine = (9Z,12Z,15Z)-octadecatrienamide + glyoxylate"}
{"X":57924,"RHEA_ID":56683,"compounds":"beta-dihydromenaquinone-9 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized [2Fe-2S]-[ferredoxin]"}
{"X":57925,"RHEA_ID":58525,"compounds":"15alpha-stemmadenine intermediate I + H2O + NADPH => (16S)-deshydroxymethyl-stemmadenine + formate + NADP(+)"}
{"X":57926,"RHEA_ID":62584,"compounds":"ATP + H2O + L-tyrosine(out) = ADP + H(+) + L-tyrosine(in) + phosphate"}
{"X":57927,"RHEA_ID":57794,"compounds":"4-methyl-6-nitrocatechol + NAD(+) + nitrite => 3,4-dinitrotoluene + NADH + O2"}
{"X":57928,"RHEA_ID":58010,"compounds":"(20S)-ginsenoside Rg1 + H(+) + UDP => (20S)-ginsenoside F1 + UDP-alpha-D-glucose"}
{"X":57929,"RHEA_ID":62078,"compounds":"6-phospho-D-galactono-1,5-lactone + H(+) + NADH => D-galactose 6-phosphate + NAD(+)"}
{"X":57930,"RHEA_ID":59967,"compounds":"L-seryl-[protein] + octanoyl-CoA <=> CoA + O-octanoyl-L-seryl-[protein]"}
{"X":57931,"RHEA_ID":61959,"compounds":"1-O-octadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + AH2 + O2 <=> 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + A + 2 H2O"}
{"X":57932,"RHEA_ID":60607,"compounds":"1-tetradecanoyl-sn-glycero-3-phosphocholine <=> 1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + choline"}
{"X":57933,"RHEA_ID":57511,"compounds":"H2O + NADP(+) + staphylopine <=> (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate"}
{"X":57934,"RHEA_ID":61342,"compounds":"CO2 + propanoyl-CoA => (S)-methylmalonyl-CoA + H(+)"}
{"X":57935,"RHEA_ID":61231,"compounds":"H2O + L-histidine + O2 <=> 3-(imidazol-5-yl)pyruvate + H2O2 + NH4(+)"}
{"X":57936,"RHEA_ID":60357,"compounds":"H2O + N-octanoylanthranilate => anthranilate + H(+) + octanoate"}
{"X":57937,"RHEA_ID":58868,"DIRECTION":"UN","MASTER_ID":58868,"ec":"1.14.18.11","compounds":"24-methylidenelophenol + 6 [Fe(II)-cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 6 [Fe(III)-cytochrome b5] + 4 H2O"}
{"X":57938,"RHEA_ID":58456,"DIRECTION":"UN","MASTER_ID":58456,"ec":"3.2.1.170","compounds":"(2R)-2-O-(alpha-D-mannosyl)-glycerate + H2O = (R)-glycerate + D-mannose"}
{"X":57939,"RHEA_ID":58662,"compounds":"a 5'-(5'-bisphosphomethyl)-ribonucleoside-RNA + S-adenosyl-L-homocysteine => a 5'-(5'-phosphomethyl)-ribonucleoside-RNA + S-adenosyl-L-methionine"}
{"X":57940,"RHEA_ID":62598,"DIRECTION":"RL","MASTER_ID":62596,"metacyc":"RXN-20745","compounds":"(6E)-8-oxogeranial + H(+) + NADH => (S)-8-oxocitronellyl enol + NAD(+)"}
{"X":57941,"RHEA_ID":61155,"compounds":"(E)-caffeoyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] <=> CoA + myricetin 3-O-[(6-O-(E)-caffeoyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]"}
{"X":57942,"RHEA_ID":57530,"compounds":"5'-phospho-ribonucleosidyl-ribonucleotide-RNA + AMP + 2 diphosphate + H(+) => 5'-end ribonucleotide-RNA + a ribonucleoside 5'-triphosphate + ATP + H2O"}
{"X":57943,"RHEA_ID":61147,"compounds":"myricetin + UDP-beta-L-rhamnose <=> H(+) + myricetin 3-O-alpha-L-rhamnoside + UDP"}
{"X":57944,"RHEA_ID":61848,"compounds":"cholesterol + UDP-alpha-D-glucose = cholesteryl 3-beta-D-glucoside + H(+) + UDP"}
{"X":57945,"RHEA_ID":56704,"DIRECTION":"UN","MASTER_ID":56704,"ec":"1.14.20.12","compounds":"(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 = 3-[(E)-2-isocyanovinyl]indole + 2 CO2 + H2O + succinate"}
{"X":57946,"RHEA_ID":60805,"DIRECTION":"LR","MASTER_ID":60804,"metacyc":"RXN1F-101","compounds":"2-oxoglutarate + gibberellin A19 + O2 => CO2 + gibberellin A17 + H(+) + succinate"}
{"X":57947,"RHEA_ID":59939,"compounds":"3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O <=> 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA + H(+)"}
{"X":57948,"RHEA_ID":60677,"compounds":"(S)-(-)-citronellol + NAD(+) => (S)-(-)-citronellal + H(+) + NADH"}
{"X":57949,"RHEA_ID":61965,"compounds":"a 1-O-octadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + AH2 + O2 => A + a 1-O-(1Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 H2O"}
{"X":57950,"RHEA_ID":59671,"compounds":"D-cellohexaose + O2 <=> D-cellohexaono-1,5-lactone + H2O2"}
{"X":57951,"RHEA_ID":62727,"compounds":"(+)-premalbrancheamide + bromide + FAD + 2 H(+) <=> (+)-isomalbrancheamide C + FADH2"}
{"X":57952,"RHEA_ID":59410,"compounds":"acetate + L-aspartate => H2O + N-acetyl-L-aspartate"}
{"X":57953,"RHEA_ID":62102,"compounds":"1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate => 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O"}
{"X":57954,"RHEA_ID":59300,"compounds":"3'-phosphoadenylyl sulfate + firefly D-luciferin = adenosine 3',5'-bisphosphate + firefly D-sulfoluciferin + H(+)"}
{"X":57955,"RHEA_ID":61485,"compounds":"a cytidine in rRNA + S-adenosyl-L-methionine => a 5-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":57956,"RHEA_ID":62581,"DIRECTION":"LR","MASTER_ID":62580,"ecocyc":"TRANS-RXN-290","metacyc":"TRANS-RXN-290","compounds":"ATP + D-cystine(out) + H2O => ADP + D-cystine(in) + H(+) + phosphate"}
{"X":57957,"RHEA_ID":58271,"compounds":"[protein]-C-terminal glycine + NAD(+) <=> [protein]-C-terminal O-(ADP-D-ribosyl)-glycine + nicotinamide"}
{"X":57958,"RHEA_ID":62730,"compounds":"(+)-malbrancheamide D + FADH2 => (+)-malbrancheamide B + bromide + FAD + 2 H(+)"}
{"X":57959,"RHEA_ID":60676,"compounds":"(S)-(-)-citronellol + NAD(+) = (S)-(-)-citronellal + H(+) + NADH"}
{"X":57960,"RHEA_ID":59349,"compounds":"D-maltobiono-1,5-lactone + H2O => D-maltobionate + H(+)"}
{"X":57961,"RHEA_ID":59979,"compounds":"2-phenylacetate + H(+) <=> CO2 + toluene"}
{"X":57962,"RHEA_ID":62349,"DIRECTION":"LR","MASTER_ID":62348,"metacyc":"RXN-16110","compounds":"H(+) + NADPH + notoamide E + O2 => H2O + NADP(+) + notoamide C"}
{"X":57963,"RHEA_ID":58769,"compounds":"1-O-(1Z-hexadecenyl)-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH => 1-O-(1Z-hexadecenyl)-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)"}
{"X":57964,"RHEA_ID":56804,"compounds":"2 cob(II)yrinate a,c diamide--[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] = 2 cob(I)yrinate a,c diamide--[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]"}
{"X":57965,"RHEA_ID":58236,"compounds":"L-tyrosyl-[protein] + NAD(+) = H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-tyrosyl-[protein]"}
{"X":57966,"RHEA_ID":61659,"compounds":"(2E,6E)-farnesol + ATP <=> (2E,6E)-farnesyl phosphate + ADP + H(+)"}
{"X":57967,"RHEA_ID":58745,"DIRECTION":"LR","MASTER_ID":58744,"ecocyc":"RXN0-7079","metacyc":"RXN0-7079","compounds":"7-methyl-GTP + H2O => 7-methyl-GMP + diphosphate + H(+)"}
{"X":57968,"RHEA_ID":60202,"compounds":"2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate => 2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2"}
{"X":57969,"RHEA_ID":61729,"compounds":"a 3-dehydro-D-guloside => a 3-dehydro-D-glucoside"}
{"X":57970,"RHEA_ID":59664,"compounds":"D-cellopentaose + O2 = D-cellopentaono-1,5-lactone + H2O2"}
{"X":57971,"RHEA_ID":58204,"compounds":"O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine = dihydroalstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":57972,"RHEA_ID":58749,"compounds":"desmethylnectriapyrone + S-adenosyl-L-methionine => H(+) + nectriapyrone + S-adenosyl-L-homocysteine"}
{"X":57973,"RHEA_ID":59004,"compounds":"dodecanal + H2O + O2 = dodecanoate + H(+) + H2O2"}
{"X":57974,"RHEA_ID":60019,"compounds":"(2E,6E)-farnesyl diphosphate <=> diphosphate + sesquisabinene B"}
{"X":57975,"RHEA_ID":61141,"DIRECTION":"LR","MASTER_ID":61140,"metacyc":"RXN-8450","compounds":"(2R,3R)-dihydromyricetin + 2-oxoglutarate + O2 => CO2 + H(+) + H2O + myricetin + succinate"}
{"X":57976,"RHEA_ID":62114,"compounds":"H2O + iminosuccinate => (3S)-3-hydroxy-D-aspartate"}
{"X":57977,"RHEA_ID":58209,"compounds":"A + dihydroalstonine => AH2 + alstonine"}
{"X":57978,"RHEA_ID":62611,"compounds":"glutathione + H(+) + hydrogen sulfide + ubiquinone-10 <=> S-sulfanylglutathione + ubiquinol-10"}
{"X":57979,"RHEA_ID":62766,"compounds":"4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O => 4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2"}
{"X":57980,"RHEA_ID":57154,"compounds":"(3S)-3-hydroxy-L-lysyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-lysyl-[protein] + O2"}
{"X":57981,"RHEA_ID":58265,"compounds":"a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol => an N-acylsphing-4-enine + cholesteryl 3-beta-D-glucoside"}
{"X":57982,"RHEA_ID":58721,"DIRECTION":"LR","MASTER_ID":58720,"metacyc":"RXN66-81","compounds":"(S)-nicotine + NADPH + O2 => H2O + NADP(+) + trans-(S)-nicotine N(1')-oxide"}
{"X":57983,"RHEA_ID":62615,"compounds":"adenosine(1832) in 18S rRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine(1832) in 18S rRNA + S-adenosyl-L-homocysteine"}
{"X":57984,"RHEA_ID":58423,"compounds":"NADP(+) + prenol <=> 3-methyl-2-butenal + H(+) + NADPH"}
{"X":57985,"RHEA_ID":58697,"compounds":"NADPH + O2 + rifampicin => H(+) + H2O + NADP(+) + rifampicin para-naphthoquinone carboxamide"}
{"X":57986,"RHEA_ID":62350,"compounds":"H2O + NADP(+) + notoamide C => H(+) + NADPH + notoamide E + O2"}
{"X":57987,"RHEA_ID":59804,"compounds":"L-phenylalanine = D-phenylalanine"}
{"X":57988,"RHEA_ID":59406,"compounds":"D-homoserine => L-homoserine"}
{"X":57989,"RHEA_ID":58841,"compounds":"cholesterol sulfate + O2 + reduced [NADPH--hemoprotein reductase] => (24S)-hydroxycholesterol 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":57990,"RHEA_ID":62520,"compounds":"a cytidine in rRNA + S-adenosyl-L-methionine = an N(4)-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine"}
{"X":57991,"RHEA_ID":60684,"compounds":"(11R)-dihydroartemisinic aldehyde + H2O + NADP(+) = (11R)-dihydroartemisinate + 2 H(+) + NADPH"}
{"X":57992,"RHEA_ID":61481,"DIRECTION":"LR","MASTER_ID":61480,"metacyc":"RXN-20364","compounds":"a sphingoid base + a very long-chain fatty acyl-CoA => an N-(very-long-chain fatty acyl)-sphingoid base + CoA + H(+)"}
{"X":57993,"RHEA_ID":58676,"compounds":"NADPH + O2 + rifamycin SV = H2O + NADP(+) + rifamycin SV para-naphthoquinone carboxamide"}
{"X":57994,"RHEA_ID":58633,"compounds":"N-tetradecanoyl-(2S)-hydroxyglycine => glyoxylate + tetradecamide"}
{"X":57995,"RHEA_ID":58419,"compounds":"(E)-4-hydroxynon-2-en-1-ol + NADP(+) <=> (E)-4-hydroxynon-2-enal + H(+) + NADPH"}
{"X":57996,"RHEA_ID":58748,"compounds":"desmethylnectriapyrone + S-adenosyl-L-methionine = H(+) + nectriapyrone + S-adenosyl-L-homocysteine"}
{"X":57997,"RHEA_ID":56944,"compounds":"AH2 + D-ribulose 5-phosphate = 1-deoxy-D-xylulose 5-phosphate + A + H2O"}
{"X":57998,"RHEA_ID":62336,"compounds":"AMP + ATP = adenosine 3'-diphosphate,5'-phosphate + AMP + H(+)"}
{"X":57999,"RHEA_ID":62325,"compounds":"(+)-malbrancheamide B + chloride + FAD + 2 H(+) => (+)-malbrancheamide + FADH2"}
{"X":58000,"RHEA_ID":58085,"compounds":"1-(13Z-docosenoyl)-glycerol + H2O => (13Z)-docosenoate + glycerol + H(+)"}
{"X":58001,"RHEA_ID":62544,"compounds":"2 [Fe(II)cytochrome c] + 3 H(+) + ouabagenin = 2 [Fe(III)cytochrome c] + dihydroouabagenin"}
{"X":58002,"RHEA_ID":56736,"compounds":"H2O + O2 + retinal = H(+) + H2O2 + retinoate"}
{"X":58003,"RHEA_ID":62580,"DIRECTION":"UN","MASTER_ID":62580,"ec":"7.4.2.12","compounds":"ATP + D-cystine(out) + H2O = ADP + D-cystine(in) + H(+) + phosphate"}
{"X":58004,"RHEA_ID":61354,"compounds":"ADP + H(+) + phosphate + riboflavin(out) => ATP + H2O + riboflavin(in)"}
{"X":58005,"RHEA_ID":57287,"compounds":"a guanosine in RNA + methylglyoxal <=> an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA"}
{"X":58006,"RHEA_ID":58537,"compounds":"glycine + hexadecanoyl-CoA => CoA + H(+) + N-hexadecanoylglycine"}
{"X":58007,"RHEA_ID":60476,"compounds":"2 ATP + GTP = cyclic AMP-AMP-GMP + 3 diphosphate"}
{"X":58008,"RHEA_ID":57898,"compounds":"a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + O2"}
{"X":58009,"RHEA_ID":58637,"compounds":"N-(9Z-octadecenoyl)-(2S)-hydroxyglycine => (9Z)-octadecenamide + glyoxylate"}
{"X":58010,"RHEA_ID":61486,"compounds":"a 5-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in rRNA + S-adenosyl-L-methionine"}
{"X":58011,"RHEA_ID":60323,"compounds":"N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine"}
{"X":58012,"RHEA_ID":58255,"compounds":"H2O + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] <=> ADP-D-ribose + L-asparaginyl-[protein]"}
{"X":58013,"RHEA_ID":62334,"compounds":"adenosine 3'-diphosphate,5'-diphosphate + AMP => ADP + ATP"}
{"X":58014,"RHEA_ID":62555,"compounds":"beta-D-glucosylceramide + UDP-alpha-D-galactose <=> beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H(+) + UDP"}
{"X":58015,"RHEA_ID":60821,"compounds":"H2O + NADPH => adenosine 3',5'-bisphosphate + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide"}
{"X":58016,"RHEA_ID":61302,"compounds":"acetaldehyde + dihydroxyacetone phosphate => 5-deoxy-D-ribulose 1-phosphate"}
{"X":58017,"RHEA_ID":62326,"compounds":"(+)-malbrancheamide + FADH2 => (+)-malbrancheamide B + chloride + FAD + 2 H(+)"}
{"X":58018,"RHEA_ID":62342,"compounds":"(+)-malbrancheamide C + FADH2 => (+)-premalbrancheamide + bromide + FAD + 2 H(+)"}
{"X":58019,"RHEA_ID":61738,"compounds":"rubusoside + UDP => steviolmonoside + UDP-alpha-D-glucose"}
{"X":58020,"RHEA_ID":61317,"DIRECTION":"LR","MASTER_ID":61316,"metacyc":"RXN-8970","compounds":"germacra-1(10),4,11(13)-trien-12-al + O2 + reduced [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":58021,"RHEA_ID":58880,"compounds":"4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 [Fe(II)-cytochrome b5] + H(+) + O2 = 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O"}
{"X":58022,"RHEA_ID":58625,"compounds":"N-dodecanoyl-(2S)-hydroxyglycine => dodecanamide + glyoxylate"}
{"X":58023,"RHEA_ID":57263,"compounds":"H2O + N(2)-(1-hydroxy-2-oxopropyl)-GDP <=> GDP + H(+) + lactate"}
{"X":58024,"RHEA_ID":58720,"compounds":"(S)-nicotine + NADPH + O2 = H2O + NADP(+) + trans-(S)-nicotine N(1')-oxide"}
{"X":58025,"RHEA_ID":58874,"compounds":"4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 [Fe(III)-cytochrome b5] + H2O => 24-methylidenelophenol + 2 [Fe(II)-cytochrome b5] + 2 H(+) + O2"}
{"X":58026,"RHEA_ID":59880,"compounds":"4-hydroxyphenylacetate + FMNH2 + O2 = 3,4-dihydroxyphenylacetate + FMN + H(+) + H2O"}
{"X":58027,"RHEA_ID":61949,"compounds":"2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl-[protein] + O2 => CO2 + formaldehyde + N(6)-methyl-L-lysyl-[protein] + succinate"}
{"X":58028,"RHEA_ID":61299,"compounds":"5-deoxy-alpha-D-ribose 1-phosphate <=> 5-deoxy-D-ribulose 1-phosphate"}
{"X":58029,"RHEA_ID":61839,"compounds":"ergosterol + UDP-alpha-D-glucose <=> ergosteryl 3-beta-D-glucoside + H(+) + UDP"}
{"X":58030,"RHEA_ID":62086,"compounds":"AMP + D-glucosamine 6-phosphate + H(+) => ADP + D-glucosamine"}
{"X":58031,"RHEA_ID":62337,"compounds":"AMP + ATP => adenosine 3'-diphosphate,5'-phosphate + AMP + H(+)"}
{"X":58032,"RHEA_ID":61355,"compounds":"ATP + H2O + riboflavin(in) <=> ADP + H(+) + phosphate + riboflavin(out)"}
{"X":58033,"RHEA_ID":60660,"compounds":"1,4-benzoquinone + H(+) + NADH = hydroquinone + NAD(+)"}
{"X":58034,"RHEA_ID":60853,"compounds":"a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-homocysteine"}
{"X":58035,"RHEA_ID":62558,"compounds":"4-methylcatechol + CO2 => 3,4-dihydroxyphenylacetate + H(+)"}
{"X":58036,"RHEA_ID":61634,"compounds":"5-aminopentanoate + 2 H(+) + NADH => 5-aminopentanal + H2O + NAD(+)"}
{"X":58037,"RHEA_ID":58626,"compounds":"dodecanamide + glyoxylate => N-dodecanoyl-(2S)-hydroxyglycine"}
{"X":58038,"RHEA_ID":61826,"compounds":"H(+) + pregnenolone 3-beta-D-glucoside + UDP => pregnenolone + UDP-alpha-D-glucose"}
{"X":58039,"RHEA_ID":59931,"compounds":"erythritol + NADP(+) <=> D-erythrose + H(+) + NADPH"}
{"X":58040,"RHEA_ID":62278,"compounds":"6 AMP + beauvericin + 6 diphosphate + 6 H(+) + 3 S-adenosyl-L-homocysteine => 3 (R)-2-hydroxy-3-methylbutyrate + 6 ATP + 3 L-phenylalanine + 3 S-adenosyl-L-methionine"}
{"X":58041,"RHEA_ID":61758,"compounds":"H(+) + rebaudioside A + UDP => stevioside + UDP-alpha-D-glucose"}
{"X":58042,"RHEA_ID":62029,"compounds":"H2O + stigmasteryl 3-beta-D-glucoside => D-glucose + stigmasterol"}
{"X":58043,"RHEA_ID":62333,"compounds":"ADP + ATP => adenosine 3'-diphosphate,5'-diphosphate + AMP"}
{"X":58044,"RHEA_ID":57526,"compounds":"a 5'-phospho-guanosine-ribonucleotide-tRNA(His) + diphosphate + H(+) => a 5'-triphospho-guanosine-ribonucleotide-tRNA(His) + H2O"}
{"X":58045,"RHEA_ID":59002,"compounds":"H(+) + H2O2 + propanoate => H2O + O2 + propanal"}
{"X":58046,"RHEA_ID":62155,"compounds":"dGMP + dTTP <=> dGDP + dTDP"}
{"X":58047,"RHEA_ID":61229,"compounds":"H2O + L-histidine + O2 => 3-(imidazol-5-yl)pyruvate + H2O2 + NH4(+)"}
{"X":58048,"RHEA_ID":57519,"compounds":"dolabradiene + O2 + reduced [NADPH--hemoprotein reductase] <=> 15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]"}
{"X":58049,"RHEA_ID":60887,"compounds":"a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine-phospho-ribonucleoside in mRNA + H2O <=> (N(7)-methyl 5'-triphospho-guanosine)-adenosine + a 5'-end phospho-ribonucleoside in mRNA + H(+)"}
{"X":58050,"RHEA_ID":59791,"compounds":"H2O + NAD(+) + pseudopaline <=> (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADH"}